pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Lumbar Plexus Block Versus Quadratus Lumborum Block for Primary Anterior Total Hip Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis|Total Hip Arthroplasty
Interventions: OTHER: LPB|OTHER: QLB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Boostrix™10 Years After Previous Booster Vaccination
Status: COMPLETED
Conditions: Acellular Pertussis|Tetanus|Diphtheria
Interventions: BIOLOGICAL: Boostrix™|BIOLOGICAL: Boostrix™-US formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Febuxostat-Controlled, Double-Blind, Comparative Study of FYU-981 in Hyperuricemia With or Without Gout
Status: COMPLETED
Conditions: Hyperuricemia With or Without Gout
Interventions: DRUG: FYU-981|DRUG: Febuxostat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Low-Dose Dexamethasone on the Incidence of Hyperglycemia Following Surgery
Status: COMPLETED
Conditions: Postoperative Complications
Interventions: DRUG: Control-saline|DRUG: Dexamethasone 4 mg|DRUG: Dexamethasone 8 mg|DRUG: Control saline|DRUG: Dexamethasone 4 mg|DRUG: Dexamethasone 8 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of Intramuscular Ziprasidone Followed by Oral Ziprasidone for the Treatment of Psychosis
Status: COMPLETED
Conditions: Schizophrenia|Mania|Delusional Disorder|Acute Exacerbation of Psychosis
Interventions: DRUG: Ziprasidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-Center Study To Examine The Use Of Flex HD® And Strattice In The Repair Of Large Abdominal Wall Hernias
Status: COMPLETED
Conditions: Hernia of Abdominal Wall
Interventions: DEVICE: FLEX-HD|DEVICE: Strattice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of CYR-064 Versus Placebo in Patients.
Status: RECRUITING
Conditions: Hyposmia
Interventions: COMBINATION_PRODUCT: CYR-064
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I TH-302 Plus Gemcitabine Plus Nab-Paclitaxel in Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: TH-302|DRUG: Nab-paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epidural and Spinal Anesthesia Techniques in Pilonidal Dermoid Sinus Surgeries
Status: UNKNOWN
Conditions: Sinus; Dermal, Pilonidal
Interventions: PROCEDURE: epidural catheter|PROCEDURE: spinal catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Ketamine for Multiple Sclerosis Fatigue
Status: RECRUITING
Conditions: Multiple Sclerosis Fatigue
Interventions: DRUG: Ketamine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TGV:Use of the Quick Diagnostic Test of the Influenza and the Infection With RSV by the Paediatric Emergency Unit
Status: COMPLETED
Conditions: Influenza|Respiratory Syncytial Viruses
Interventions: DEVICE: RSV respi-strip and Quick-vue influenza
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bone Marrow Stem Cell Mobilisation Therapy for Acute Myocardial Infarction (AMI)(REVIVAL-2)
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: G-CSF Granulocyte-Colony Stimulating Factor|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing NUC-1031 Plus Cisplatin to Gemcitabine Plus Cisplatin in Patients With Advanced Biliary Tract Cancer
Status: TERMINATED
Conditions: Biliary Tract Cancer
Interventions: DRUG: NUC-1031|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Proton and Carbon Ion Radiotherapy With Advanced Photon Radiotherapy in Skull Base Meningiomas: The PINOCCHIO Trial.
Status: WITHDRAWN
Conditions: Skull Base Meningioma
Interventions: RADIATION: Carbon Ion Radiotherapy|RADIATION: Proton Therapy|RADIATION: Hypofractionated Photon Radiotherapy|RADIATION: Conventional Photon Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Selpercatinib After Surgery or Radiation in Participants With Non-Small Cell Lung Cancer (NSCLC)
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Selpercatinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tumor Hypoxia With HX4 PET in Several Diseases
Status: TERMINATED
Conditions: Prostatic Neoplasms|Esophageal Neoplasms|Neoplasm Metastases, Brain|Rectal Neoplasms|Brain Neoplasm, Primary
Interventions: DRUG: Injection with the hypoxia tracer [18F]HX4,
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Reducing Cesarean Section Rates and Enhancing Vaginal Delivery in Greece: a Stepped-Wedge Randomized Controlled Trial
Status: COMPLETED
Conditions: Cesarean Section Rates
Interventions: BEHAVIORAL: HSOG guidelines application|BEHAVIORAL: Interactive workshops and courses|BEHAVIORAL: Feedback through follow-up meetings|BEHAVIORAL: Robson criteria usage|BEHAVIORAL: Access to live real-time statistics|BEHAVIORAL: Attendance of local cesarean section meetings|BEHAVIORAL: Attendance of local CTG interpretation meetings|BEHAVIORAL: Reminders of proper clinical practice|OTHER: HSOG guidelines implementation|OTHER: Interactive workshops and courses training|OTHER: Implementation of Robson criteria classification|OTHER: Live real-time statistics online platform|OTHER: Local cesarean section meetings|OTHER: Local CTG interpretation meetings|OTHER: Follow-up meetings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Renal Sympathectomy in Treatment Resistant Essential Hypertension, a Sham Controlled Randomized Trial
Status: COMPLETED
Conditions: Hypertension
Interventions: PROCEDURE: Renal artery ablation|PROCEDURE: Renal angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Validation of a Making Decision Hybrid (Ecologic and Virtual) Task
Status: NOT_YET_RECRUITING
Conditions: Healthy Volunteers|Behavior and Behavior Mechanisms
Interventions: DEVICE: Neurophysiological measure (EEG)|OTHER: Survey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Heart Matters: The Effectiveness of Heart Health Education in Regions at Highest-risk.
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Myocardial Infarction, Acute
Interventions: OTHER: Community education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose Response of Neural Mobilization on Hamstring Flexibility in Low Back Pain
Status: COMPLETED
Conditions: Non-specific Low Back Pain
Interventions: OTHER: High Dose Neural Mobilization Technique|OTHER: Low Dose Neural Mobilization Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prognostic Study of Markers of Angiogenesis and Coagulability in Patients With Monoclonal Gammopathy
Status: COMPLETED
Conditions: Monoclonal Gammopathy|Monoclonal Gammopathy of Undetermined Signification|Myeloma
Interventions: OTHER: blood and bone marrow samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatments for Fathers With ADHD and Their At-Risk Children (Fathers Too)
Status: COMPLETED
Conditions: Attention Deficit/Hyperactivity Disorder (ADHD)
Interventions: DRUG: Vyvanse|BEHAVIORAL: Behavioral Parent Training|DRUG: Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-meal Consumption of Whey in Gestational Diabetes Mellitus From Diagnosis to Delivery
Status: COMPLETED
Conditions: Gestational Diabetes
Interventions: DIETARY_SUPPLEMENT: Whey|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Therapy of Gefitinib (Iressa, ZD1839) in Patients With Resectable Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Liver Cancer
Interventions: DRUG: Gefetinib (Iressa)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Effectiveness and Safety of Bioresorbable Vascular Scaffold in Routine Clinical Practice
Status: TERMINATED
Conditions: Arterial Occlusive Diseases|Cardiovascular Diseases|Coronary Artery Disease|Coronary Disease
Interventions: DEVICE: Bioresorbable Vascular Scaffold
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Eszopiclone on Sleep and Memory in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: eszopiclone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intravenous Lidocaine on BIS-guided Propofol Requirements During General Anesthesia
Status: COMPLETED
Conditions: Intravenous Anesthetic Interaction "Unrecognized Condition"
Interventions: DRUG: Intravenous lidocaine infusion|OTHER: Placebo (0.9% saline infusion)|DRUG: Propofol 1% (intravenous infusion)|PROCEDURE: Placement of arterial line
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Periprosthetic Bone Remodeling in Femoral Neck Fracture Patients; a 5-year Follow up Study
Status: COMPLETED
Conditions: Bone Mineral Density|Femoral Neck Fractures
Interventions: OTHER: Dual-energy X-ray absorbtiometry to evaluate periprosthetic bone mineral density around an uncemented stem implanted using either lateral or anterolateral approach to the hip joint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Comparison Between Midline and Right-sided Insertion of the Videolaryngoscope for Endotracheal Intubation
Status: COMPLETED
Conditions: Intubation; Difficult or Failed
Interventions: PROCEDURE: Different Approach to endotracheal intubation.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Implementation and Quality Assurance of DPYD-genotyping in Patients Treated With Fluoropyrimidines.
Status: COMPLETED
Conditions: Adverse Drug Event|Colon Cancer|Breast Cancer|Pancreas Cancer|Rectal Cancer|Gastric Cancer|Oesophageal Cancer|Bile Duct Cancer
Interventions: GENETIC: DPYD genotype
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Decitabine/Cedazuridine and Enzalutamide for the Treatment of Metastatic Castrate Resistant Prostate Cancer
Status: RECRUITING
Conditions: Castration-Resistant Prostate Carcinoma|Stage IV Prostate Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8|Stage IVB Prostate Cancer AJCC v8
Interventions: DRUG: Decitabine and Cedazuridine|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes of Robotic Versus Laparoscopic Distal Gastrectomy for Gastric Cancer
Status: COMPLETED
Conditions: Stomach Neoplasm|Robotic Surgery
Interventions: PROCEDURE: Robotic Distal Gastrectomy|PROCEDURE: Laparoscopic Distal Gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMPACT of an Instrumented Measurement on a Performance Assessment in Cerebral Palsy Treatment
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: AHA Not Instrumented then AHA Instrumented|OTHER: AHA Instrumented then AHA Not Instrumented
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effects of Rosuvastatin on Aortic Stenosis Progression
Status: COMPLETED
Conditions: Aortic Stenosis
Interventions: DRUG: Rosuvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Scapular Stabilization During Manual Horizontal Adduction Stretches and Its Effect on Increasing Posterior Shoulder Flexibility
Status: COMPLETED
Conditions: Posterior Shoulder Tightness
Interventions: OTHER: horizontal adduction stretch with scapular stabilization|OTHER: Horizontal adduction stretch without scapular stabilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Clinical Trial About Treatment of Benign Uterus Myoma by Haifu Focused Ultrasound Tumor Therapeutic System
Status: NOT_YET_RECRUITING
Conditions: Benign Uterine Tumor
Interventions: DEVICE: Haifu Focused Ultrasound tumor therapeutic System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predicting Hypoglycaemia and Arrhythmias in the Vulnerable Patient With Diabetes and Chronic Kidney Disease
Status: COMPLETED
Conditions: Electrocardiography
Interventions: DEVICE: medilog® DARWIN FD12|DEVICE: Continuous Glucose Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of RM-004 Cells for Hemoglobin H-Constant Spring Disease
Status: RECRUITING
Conditions: Alpha Thalassemia Hemoglobin H Constant Spring|Hemoglobinopathies|Hereditary Diseases
Interventions: GENETIC: RM-004
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Toxicity of Gemcitabine/Lobaplatin Versus Gemcitabine/Cisplatin as Second-line Treatment in Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: lobaplatin|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supportive Care Mobile Application for Patients With NSCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer|Quality of Life|Coping Skills
Interventions: BEHAVIORAL: Supportive Care Mobile Application|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ReAssessment of Anti-Platelet Therapy Using an InDividualized Strategy Based on GENetic Evaluation
Status: COMPLETED
Conditions: Stable Coronary Artery Disease|Acute Coronary Syndrome|Percutaneous Coronary Intervention
Interventions: GENETIC: Point-of-care genetic screening with subsequent prasugrel administration to CYP2C19*2 carriers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction Chemotherapy Combined With Camrelizumab in Locoregionally Advanced Hypopharyngeal Cancer
Status: UNKNOWN
Conditions: Hypopharyngeal Cancer|Immunotherapy|Induction Chemotherapy
Interventions: DRUG: Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caudal Block Versus Quadratus Lumborum Plane Block in Lumbar Surgery
Status: RECRUITING
Conditions: Spondylolisthesis|Facet Joint Hypertrophy|Spinal Canal Stenosis
Interventions: PROCEDURE: Caudal|PROCEDURE: Quadratus lumborum plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics of Tasimelteon Alone and in Combination With CYP1A2 Inhibitor, Fluvoxamine
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Tasimelteon|DRUG: Fluvoxamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase III Study With Teriflunomide Versus Placebo in Patients With First Clinical Symptom of Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Teriflunomide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Submucosa/Mucosal Pharyngeal Flap Trial
Status: UNKNOWN
Conditions: Velopharyngeal Insufficiency
Interventions: PROCEDURE: Mucosa/submucosa Pharyngeal Flap|PROCEDURE: Standard of Care Pharyngeal Flap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of CPAP Level on Respiratory Mechanics and Central Drive in Patients With COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: PROCEDURE: CPAP level
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Refraction Measurments in Children Under General Anesthesia, With and Without Cycloplegic Drops
Status: UNKNOWN
Conditions: General Anesthesia
Interventions: OTHER: instulling cyclopentolate drops in the eye
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Use of Topical Solasodine of Solanum Melongena Peel Origin in the Treatment of Palmar Arsenic Keratosis
Status: UNKNOWN
Conditions: Keratotic Nodular Size
Interventions: DRUG: Arsenic Keratosis lesion or nodular size observation after 12 weeks of therapy with solasodine ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) as an add-on Treatment for Resistant OCD
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: PROCEDURE: repetitive transcranial magnetic stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Conscious Sedation to Retrobulbar Block Anesthetics During Trans-scleral Diode Laser
Status: COMPLETED
Conditions: Glaucoma
Interventions: PROCEDURE: Retrobulbar Block|PROCEDURE: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Insulin Action in Individuals With Type 2 Diabetes by Natural Fatty Acids or the Medication Pioglitazone
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Pioglitazone 45 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Fenofibrate in Neonatal Jaundice
Status: COMPLETED
Conditions: Neonatal Jaundice
Interventions: DRUG: Fenofibrate|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Intelligent Exercise on Vascular Function, Grip Strength and Adherence in Patients With AVF After Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Arteriovenous Fistula|Isometric Exercise
Interventions: BEHAVIORAL: Forearm isometric exercise intervention program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Evaluate Symptoms in Patients Treated With Nebivolol or Metoprolol Extended-release (ER) for Hypertension
Status: TERMINATED
Conditions: Hypertension
Interventions: DRUG: Metoprolol ER|DRUG: Nebivolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of CSII and CGM on Progression of Late Diabetic Complications
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: Insulin pump therapy (CSII) plus continuous glucose monitoring (CGM)|OTHER: Multiple daily insulin injections (MDI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Protocol of Arsenic Trioxide (Trisenox) in Subjects With Advanced Primary Carcinoma of the Liver
Status: TERMINATED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: arsenic trioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VR-Guided Mindfulness for ESKD Caregiver Well-Being
Status: NOT_YET_RECRUITING
Conditions: Kidney Failure, Chronic
Interventions: BEHAVIORAL: VR-guided mindfulness|OTHER: Sham VR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intraperitoneal Administration of Fosfomycin, Metronidazole and Molgramostim Versus Intravenous Antibiotics for Perforated Appendicitis
Status: COMPLETED
Conditions: Appendicitis Perforated
Interventions: DRUG: Combination of fosfomycin, metronidazole and rhGM-CSF (administered together intraperitoneally) and three days of antibiotics p.o.|DRUG: Standard antibiotics intravenously
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Inetetamab Plus Pyrotiniband and Capecitabine in HER2-positive Metastatic Breast Cancer Patients With or Without Brain Metastasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Inetetamab plus pyrotiniband and capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of SU11248 In Patients With Metastatic Breast Cancer Who Have Failed Selected Other Therapies.
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: SU011248
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Anxiolysis With Intravenous Midazolam on Intraoperative Sevoflurane Gas Consumption
Status: COMPLETED
Conditions: Midazolam|Sevoflurane
Interventions: DRUG: Midazolam|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Health Intervention on Fear of Hypoglycemia
Status: NOT_YET_RECRUITING
Conditions: Health-Related Behavior|Health Education|Fear of Hypoglycemia|Impaired Awareness of Hypoglycemia|Self-Management|Type2 Diabetes Mellitus
Interventions: BEHAVIORAL: Routine Care|BEHAVIORAL: Based on BCW Theory of Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lidocaine 5% Plasters (Versatis® 5%) in Pediatric Neuropathic Pains and Vasoocclusive Sickle Cell Crisis Pains
Status: COMPLETED
Conditions: Neuropathic Pains|Vasoocclusive Sickle Cell Crises Pains
Interventions: DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acelarin First Line Randomised Pancreatic Study
Status: SUSPENDED
Conditions: Pancreatic Acinar Carcinoma|Pancreatic Neoplasms
Interventions: DRUG: Acelarin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diaplacental Transfer of Anti-HCMV- and Anti-VZV-immunoglobulin G (IgG) -Antibodies at Premature and Mature Newborns
Status: UNKNOWN
Conditions: Materno-fetal Transfer of Anti-HCMV-IgG|Materno-fetal Transfer of Anti-VZV-IgG
Interventions: OTHER: Blood samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Clopidogrel-based Antiplatelet Therapy Versus Warfarin as Secondary Prevention Strategy for AntiPhospholipid Syndrome-related STROKE
Status: RECRUITING
Conditions: Antiphospholipid Syndrome|Ischemic Stroke|Transient Ischemic Attack|Cerebrovascular Disease|Cardiovascular Diseases|Major Bleed
Interventions: DRUG: Antiplatelet Drug|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase III Clinical Trial of NPB-01 in Patients With Stevens-Johnson Syndrome/ Toxic Epidermal Necrolysis Unresponsive to Corticosteroids.
Status: COMPLETED
Conditions: Stevens-Johnson Syndrome|Toxic Epidermal Necrolysis
Interventions: DRUG: Intravenous immunoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Subcutaneous (SC) Versus Intravenous (IV) Administration of Herceptin (Trastuzumab) in Women With Human Epidermal Growth Factor Receptor (HER) 2-Positive Early Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: 5-Fluorouracil|DRUG: Cyclophosphamide|DRUG: Docetaxel|DRUG: Epirubicin|DRUG: Herceptin IV [trastuzumab]|DRUG: Herceptin SC [trastuzumab]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficacy of Indacaterol Versus Placebo Over 12 Weeks
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Indacaterol|DRUG: Placebo to indacaterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Initial Local Anesthetic Dose With Continuous Interscalene Analgesia
Status: COMPLETED
Conditions: Post-operative Pain
Interventions: DRUG: Ropivacaine|DRUG: Ropivacaine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Deep Breathing and Cough Exercise on Respiratory Parameters in Patients With Covid-19 Associated Pneumonia
Status: RECRUITING
Conditions: COVID-19 Pneumonia|Respiratory Disease
Interventions: OTHER: deep breathing and coughing exercises with triflo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Drug-Drug Interaction Study Between ATI-2173 and Midazolam or Clarithromycin in Healthy Subjects
Status: COMPLETED
Conditions: Drug Drug Interaction
Interventions: DRUG: ATI-2173|DRUG: Midazolam|DRUG: Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mediterranean Diet Intervention to Improve Gastrointestinal Function in Parkinson's Disease a Randomized, Controlled, Clinical Trial
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: Standard of care + Mediterranean diet (intervention)|OTHER: Standard of care (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Genetic Polymorphisms on the Clinical Response to SGLT2 Inhibitors in Heart Failure Patients
Status: RECRUITING
Conditions: Genetic Polymorphisms|Heart Failure
Interventions: DRUG: SGLT2 inhibitors (Dapagliflozin and Empagliflozin)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Immunogenicity of Sanaria's Irradiated Sporozoite Vaccine (PfSPZ Vaccine) in Malaria-Experienced Adults in Burkina Faso
Status: COMPLETED
Conditions: Plasmodium Falciparum Infection
Interventions: DRUG: Artesunate|BIOLOGICAL: PfSPZ Vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Haloperidol vs Olanzapine for the Management of ICU Delirium
Status: TERMINATED
Conditions: Delirium|Agitation
Interventions: DRUG: Haloperidol|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Simultaneous mRNA COVID-19 and IIV Vaccination in Pregnancy Study
Status: NOT_YET_RECRUITING
Conditions: Birth Outcomes|Safety|Adverse Event Following Immunization
Interventions: BIOLOGICAL: mRNA COVID-19 vaccine|BIOLOGICAL: IIV4 (quadrivalent inactivated influenza vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Family Centered Intervention After Traumatic Brain Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: The Traumatic Brain Injury Family System Intervention.|BEHAVIORAL: Psycho-educational session at OUH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effectiveness of PENG Block in Programmed Hip Arthroplasty Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: ultrasound-guided PENG bloc realized before surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Study to Evaluate the Safety and Pharmacokinetics of CKD-344 in Healthy Volunteers
Status: UNKNOWN
Conditions: Anticoagulant
Interventions: DRUG: Lixiana(D006)|DRUG: CKD-344
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiopulmonary and Metabolic Responses to Early Exercise in Patients After Coronary Arterial Bypass Grafting
Status: UNKNOWN
Conditions: Acute Myocardial Infarction: Rehabilitation Phase|Coronary Artery Bypass Graft Triple Vessel|Physical Activity
Interventions: OTHER: Cycle ergometer exercise rehabilitation protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Conservative Therapies for the Alleviation of Knee Pain in Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: BEHAVIORAL: Standard Physiotherapy|OTHER: Myofascial-specific therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety in Administrating CNU® Capsule to Refractory Functional Dyspepsia Patients
Status: COMPLETED
Conditions: Dyspepsia|Biliary Dysplasia
Interventions: DRUG: efficacy and safety of CNU® Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization of Gut Microbiota Composition and Activity After a Daily Supplementation of 4.5 g/Day of ChitinGlucan Fibre During 3 Weeks in At-cardiometabolic Risk Volunteers
Status: COMPLETED
Conditions: Cardiometabolic Risk|Abdominal Obesity
Interventions: DIETARY_SUPPLEMENT: Kiotransine (chitin-glucan from aspergillus niger)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Alternative Dosing Schedule of Varenicline for Smoking Cessation
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: varenicline|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of AZD5055 on the Pharmacokinetics (PK) of Nintedanib in Healthy Participants.
Status: TERMINATED
Conditions: Healthy Subjects
Interventions: DRUG: Nintedanib|DRUG: AZD5055
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating How Course Modality Influences the Effectiveness of the R3 Academy for Dads
Status: RECRUITING
Conditions: Program Modality
Interventions: OTHER: Livestream Modality (treatment)|OTHER: Live Modality (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of the Efficacy of Paclitaxel-releasing Balloon Catheter System Versus the Everolimus-Eluting Stent System for Treatment of In-Stent Restenosis Lesions - Harmonizing Optimal Strategy for Treatment of In-Stent Restenosis Lesions (The HOST-ISR Trial) -
Status: UNKNOWN
Conditions: In-stent Restenosis Lesion
Interventions: DEVICE: Paclitaxel-eluting balloon catheter|DEVICE: Everolimus-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: CGRP-induced Migraine Attacks in Patients Who Have Tried Anti-CGRP Monoclonal Antibody Treatment
Status: UNKNOWN
Conditions: Migraine
Interventions: DRUG: Calcitonin Gene-Related Peptide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Switch From Nevirapine-based Regimen to Once a Day Rilpivirine/Emtricitabine/Tenofovir
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Rilpivirine/Emtricitabine/Tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Progesterone for the Treatment of Traumatic Brain Injury III
Status: TERMINATED
Conditions: Traumatic Brain Injury
Interventions: DRUG: Progesterone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Chronic Obstructive Pulmonary Disease (COPD) With Iodinated Activated Charcoal
Status: COMPLETED
Conditions: Chronic Obstructive Lung Disease
Interventions: DRUG: Iodinated Active Charcoal (IodoCarb)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolebrutinib, a Brain-penetrant Bruton's Tyrosine Kinase Inhibitor, for the Modulation of Chronically Inflamed White Matter Lesions in Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: tolebrutinib 60mg|DRUG: tolebrutinib 120mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Canakinumab in Patients With Myelofibrosis
Status: RECRUITING
Conditions: Primary Myelofibrosis|Post-essential Thrombocythemia Myelofibrosis|ET-MF|Post-polycythemia Vera Related Myelofibrosis|PV-MF
Interventions: DRUG: Canakinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-operative Air Leak Management After Minimally Invasive Lung Segmental Resection
Status: RECRUITING
Conditions: Lung Cancer Stage I|Lung; Node|Air Leak From Lung
Interventions: DEVICE: Polymeric Hydrogel Matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of 12-wk Treatment With Two Doses of Tiotropium Respimat in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Placebo Respimat|DRUG: Tiotropium bromide 5 mcg|DRUG: tiotropium bromide-low dose-2.5mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of an Early Palliative Care Intervention for Metastatic Cancer Patients. A Phase 2 Study.
Status: COMPLETED
Conditions: Lung Cancer|Mesothelioma|Pancreas Cancer|Gastric Cancer
Interventions: OTHER: The early palliative care programme
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Electrical Stimulation With Different Currents and Electromagnetic Fields
Status: UNKNOWN
Conditions: Healthy
Interventions: DEVICE: Neo-Russian|DEVICE: Aussie|DEVICE: RBS|DEVICE: RBS-IPI|DEVICE: HIFEM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Anti-inflammatory and Anti-plaque Efficacies of Mouth Rinse Containing Hyaluronic Acid and Hydrogen Peroxide
Status: COMPLETED
Conditions: Plaque Induced Gingivitis|Mouth Diseases|Bleeding Gum|Periodontal Diseases
Interventions: DRUG: Perhyal rinse|DRUG: Chlorhexidine mouthwash|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transdiagnostic Behavioral Activation Therapy for Youth Anxiety and Depression
Status: COMPLETED
Conditions: Depressive Disorder|Anxiety Disorders
Interventions: BEHAVIORAL: Group Behavioral Activation Therapy (GBAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Finding Study of Preladenant (SCH 420814) for the Treatment of Parkinson's Disease (PD) in Japanese Patients (P06402)
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Preladenant|DRUG: Placebo tablet to match Preladenant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exploring Methods for Treating Hypergastrinemia in Patients With Autoimmune Gastritis
Status: RECRUITING
Conditions: Autoimmune Gastritis
Interventions: OTHER: oral administration of receives only oral administration of placebo|OTHER: oral administration of compound digestive enzyme capsule|OTHER: oral administration of Betaine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Food Effect and Relative Bioavailability Study of Rilzabrutinib in Healthy Participants
Status: COMPLETED
Conditions: Autoimmune Disorder|Healthy Volunteers
Interventions: DRUG: Rilzabrutinib crystalline form|DRUG: Rilzabrutinib amorphous form
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nashville Early Diagnosis Lung Cancer Project
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer
Interventions: PROCEDURE: Sputum sample|PROCEDURE: Pulmonary function tests|RADIATION: Computerized tomography (CT) scan of the chest|OTHER: Buccal epithelium collection|PROCEDURE: Nasal brushings|PROCEDURE: Bronchoscopy|PROCEDURE: Bronchoalveolar lavage|PROCEDURE: Blood sample collection|PROCEDURE: Urine sample|PROCEDURE: Questionnaire-data collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Analgesic Effect of Paracetamol, Paracetamol + Codeine, Ibuprofen and Their Combination
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Ibuprofen + Paracetamol|DRUG: Ibuprofen + Paracetamol + Codeine|DRUG: Paracetamol + Codeine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrated Molecular Profiling in Advanced Cancers Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Non-small Cell Lung Cancer|Colorectal Cancer|Genitourinary Cancer|Pancreatobiliary Gastrointestinal Cancer|Upper Aerodigestive Tract Cancer|Gynecological Cancers|Melanoma Cancers|Rare Cancers|Unknown Primary Cancers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Systematic Pelvic Lymphadenectomy Versus no Lymphadenectomy in Clinical Stage I-II Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Cancer
Interventions: PROCEDURE: Systematic pelvic lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Technological Intervention for Reducing Alcohol Use Among People Living With HIV/AIDS
Status: COMPLETED
Conditions: Acquired Immunodeficiency Syndrome|HIV/AIDS|Alcohol Drinking
Interventions: BEHAVIORAL: Project TRAC: Tracking and Reducing Alcohol Consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RC48 Combined With Toripalimab as Neoadjuvant Therapy for Cisplatin Ineligible MIBC Patients
Status: RECRUITING
Conditions: Bladder Cancer|Muscle-Invasive Bladder Carcinoma
Interventions: DRUG: DisitamabVedotinForIicction Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Islatravir (MK-8591) Once-Monthly as Preexposure Prophylaxis (PrEP) in Men and Transgender Women Who Are at High Risk for HIV-1 Infection (MK-8591-024)
Status: COMPLETED
Conditions: HIV Preexposure Prophylaxis
Interventions: DRUG: ISL|DRUG: FTC/TDF|DRUG: FTC/TAF|DRUG: Placebo to ISL|DRUG: Placebo to FTC/TDF|DRUG: Placebo to FTC/TAF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pegylated Liposomal Doxorubicin Versus Pirarubicin Plus Ifosfamide, Dacarbazine in Locally Advanced, Unresectable or Metastatic Soft-tissue Sarcoma
Status: WITHDRAWN
Conditions: Progression-free Survival|Overall Survival|Toxicity
Interventions: DRUG: pegylated liposomal doxorubicin|DRUG: pirarubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Exercise and Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: BEHAVIORAL: Community-based Exercise Intervention group (CBE)|BEHAVIORAL: Exercise Education Control group (EEG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Window of Opportunity Trial of Entinostat in Patients With Newly Diagnosed Stage I-IIIC,TNBC
Status: TERMINATED
Conditions: Breast Cancer|Invasive Breast Cancer|ER-Negative PR-Negative HER2-Negative Breast Cancer
Interventions: DRUG: Entinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The KHENERGY Study
Status: COMPLETED
Conditions: Mitochondrial Diseases|Mitochondrial Myopathies|Mitochondrial Encephalomyopathies|MELAS|MIDD
Interventions: DRUG: KH176|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low Dose RT to Reduce Cerebral Amyloidosis in Early Alzheimer's
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: RADIATION: 10 GY in 5 daily fractions|RADIATION: 20 GY in 10 daily fractions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT