pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study to Assess the Efficacy and Safety of Atuliflapon in Moderate-to-Severe Uncontrolled Asthma
Status: RECRUITING
Conditions: Asthma
Interventions: DRUG: Atuliflapon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Indwelling Pleural Catheter With Either Doxycycline or Saline at Day 7 for Pleurodesis
Status: TERMINATED
Conditions: Advanced Cancers|Malignant Pleural Effusions
Interventions: BEHAVIORAL: Questionnaires|DRUG: Fentanyl Patch|DRUG: Fentanyl (IV)|OTHER: Saline|DRUG: Doxycycline|BEHAVIORAL: Phone Calls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fulvestrant or Capecitabine Combined With Pyrotinib in HR+/HER2+ Metastatic Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Fulvestrant combined with Pyrotinib|DRUG: Capecitabine combined with Pyrotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep and Tracking Effects in Pregnancy Study
Status: NOT_YET_RECRUITING
Conditions: Pregnancy Complications|Pregnancy Related|Weight Gain|Weight Change Trajectory|High Risk Pregnancy|Stress, Emotional
Interventions: BEHAVIORAL: Activity Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Chemotherapy Options for the First Line Chemotherapy in Elderly Patient With Advanced Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: Capecitabine/cisplatin|DRUG: S-1/cisplatin|DRUG: Capecitabine/oxaliplatin|DRUG: 5-fluorouracil/oxaliplatin|DRUG: Capecitabine|DRUG: S-1|DRUG: 5-fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measuring the Impact of Integrating Maternal and Newborn HIV Testing With Childhood Immunization Services
Status: COMPLETED
Conditions: HIV
Interventions: OTHER: HIV testing commodity reinforcement|OTHER: Policy reinforcement meeting|OTHER: Opt-out HIV testing for mothers and newborns|OTHER: Operational support for service integration|OTHER: Community sensitization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of GSK Neisseria Gonorrhoeae GMMA (NgG) Investigational Vaccine When Administered to Healthy Adults 18 to 50 Years of Age.
Status: ACTIVE_NOT_RECRUITING
Conditions: Sexually Transmitted Diseases
Interventions: BIOLOGICAL: NgG low dose investigational vaccine|BIOLOGICAL: NgG medium dose investigational vaccine|BIOLOGICAL: NgG high dose investigational vaccine|BIOLOGICAL: Placebo|BIOLOGICAL: NgG HTD investigational vaccine|BIOLOGICAL: NgG below HTD investigational vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TUPKRP Combined With MAB Therapy for LUTS/PCa
Status: NOT_YET_RECRUITING
Conditions: Advanced Prostate Cancer|Lower Urinary Tract Symptoms|Quality of Life|Overall Survival|Progression of Prostate Cancer
Interventions: PROCEDURE: Surgery combinate with Endocrine therapy|DRUG: Endocrine therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LM-108 Antibody Combination With Sintilimab for Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: NSCLC|PD-1
Interventions: DRUG: LM-108 antibody and sintilimab|DRUG: LM-108 antibody and sintilimab and chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Study to Compare Polysomnography With Overnight Home Oximetry and Auto - CPAP for Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: PROCEDURE: Ambulatory diagnosis and titration with nasal CPAP using over night oxymetry and auto CPAP and vs conventional diagnosis and titration using polysomnography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dapagliflozin on Hyperlipidemia and Insulin Resistance in Type 2 Diabetic Patients (DAPHNIS Study)
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vagus Nerve Stimulation(VNS) As Treatment For Fibromyalgia Patients
Status: NOT_YET_RECRUITING
Conditions: Fibromyalgia
Interventions: DEVICE: Transcutaneous Vagus Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualized Exercise Programs for Patients Receiving Chemotherapy for Newly Diagnosed Acute or Relapsed Myeloid Leukemia or Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Depression|Fatigue|Leukemia|Musculoskeletal Complications|Psychosocial Effects of Cancer and Its Treatment
Interventions: BEHAVIORAL: Resting vitals|BEHAVIORAL: Body Composition|BEHAVIORAL: Timed Get-up and Go test (TGUG).|BEHAVIORAL: Cardiorespiratory assessment|BEHAVIORAL: Handgrip evaluation|BEHAVIORAL: Dynamic muscular endurance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Triclosan Coated Sutures in Preventing Leg Wound Infection After Coronary Artery Bypass Surgery
Status: UNKNOWN
Conditions: Complication of Coronary Artery Bypass Graft|Surgical Wound Infection
Interventions: DRUG: Triclosan|OTHER: Conventional non-coated surgical sutures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Glycogen and Appetite
Status: RECRUITING
Conditions: Energy Intake
Interventions: DIETARY_SUPPLEMENT: Exercise plus carbohydrate|DIETARY_SUPPLEMENT: Exercise plus niacin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pharmacokinetic Study of MP-214 in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: MP-214 3mg|DRUG: MP-214 6mg|DRUG: MP-214 9mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sideritis Supplementation, Oxidative Stress and Health
Status: COMPLETED
Conditions: Oxidative Stress|Lipidemia
Interventions: DIETARY_SUPPLEMENT: Sideritis Scardica (SidTea+) extract supplementation|DIETARY_SUPPLEMENT: Placebo supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Serum Cartilage Oligomeric Matrix Protein Levels After 12 Weeks of Different Exercises
Status: COMPLETED
Conditions: Osteoarthritis|Articular Cartilage Disorder of Knee|Degenerative Lesion of Articular Cartilage of Knee
Interventions: OTHER: Running exercise|OTHER: Cycling exercise|OTHER: Swimming Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: LOW CYCLO: Study Evaluating the Benefit of Two Doses of Ciclosporine in de Novo Cardiac Transplant
Status: UNKNOWN
Conditions: Cardiac Transplantion
Interventions: DRUG: Ciclosporine 130 µg/l < T0 ciclosporinemia < 200 µg/l|DRUG: Ciclosporine 200 µg/l < T0 ciclosporinemia < 300 µg/l
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Drug Drug Interaction Trial With Strong CYP3A4 Inhibitor (Itraconazole) in CYP2C19 Extensive Metabolizers and Poor Metabolizers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 409306|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Super-Selective Intraarterial Intracranial Infusion of Bevacizumab (Avastin) for Glioblastoma Multiforme
Status: RECRUITING
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Fluconazole on the Levels of ASCA After Surgical Resection for Crohn's Disease.
Status: TERMINATED
Conditions: Crohn's Disease Aggravated
Interventions: DRUG: Fluconazole|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Community-based Program That Supports Physical Activity, Healthy Eating, Social Participation and System Navigation in Older Adults
Status: RECRUITING
Conditions: Mobility Limitation|Health Related Quality of Life|Healthy Aging|Health Inequity
Interventions: BEHAVIORAL: 3 month community-based mobility and health intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Dysport® Treatment of Urinary Incontinence in Adults Subjects With Neurogenic Detrusor Overactivity (NDO) Due to Spinal Cord Injury or Multiple Sclerosis - Study 2
Status: TERMINATED
Conditions: Urinary Incontinence|Overactive Bladder
Interventions: BIOLOGICAL: Botulinum toxin type A|BIOLOGICAL: Botulinum toxin type A|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Prophylactic Antibiotics to Prevent Post Endoscopic Retrograde Cholangio Pancreatography Bacteremia in Biliary Obstruction Patient
Status: UNKNOWN
Conditions: Biliary Obstructive Disease Such as Choledocholithiasis|Benign Biliary Stricture|Peri-ampullary Cancer|Bile Duct Cancer Resectable|Klatskin Tumor
Interventions: BIOLOGICAL: Pacetin® (cefoxitin)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Paclitaxel (Albumin-bound) Combined With Radiotherapy for the Treatment of Early Stage Nasopharyngeal Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Albumin-Bound Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sunitinib Malate and Bevacizumab in Treating Patients With Kidney Cancer or Advanced Solid Malignancies
Status: COMPLETED
Conditions: Clear Cell Renal Cell Carcinoma|Recurrent Renal Cell Cancer|Stage I Renal Cell Cancer|Stage II Renal Cell Cancer|Stage III Renal Cell Cancer|Stage IV Renal Cell Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: sunitinib malate|BIOLOGICAL: bevacizumab|OTHER: pharmacological study|OTHER: laboratory biomarker analysis|OTHER: fluorine F 18 fluorothymidine|PROCEDURE: positron emission tomography|PROCEDURE: computed tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Visual Functions and Side-effects After DSAEK or DMEK for Fuchs' Endothelial Dystrophy
Status: ACTIVE_NOT_RECRUITING
Conditions: Fuchs' Endothelial Dystrophy
Interventions: PROCEDURE: Phaco-DSAEK|PROCEDURE: Phaco-DMEK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Influence of Neoadjuvant Therapy on the Resectability of Hepatic Metastases From Colorectal Cancers
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: PROCEDURE: Hepatic resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Trial to Assess the Safety and Tolerability of Lucinactant for Inhalation in Premature Neonates
Status: COMPLETED
Conditions: Respiratory Distress Syndrome
Interventions: DRUG: Lucinactant for Inhalation|DEVICE: nCPAP alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of Docetaxel Or Docetaxel Plus PF-3512676 To Treat Patients With Advanced Breast Cancer.
Status: WITHDRAWN
Conditions: Breast Neoplasms
Interventions: DRUG: docetaxel|DRUG: PF-3512676
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Dexmedetomidine Versus Intrathecal Morphine Inpatients Undergoing Cardiac Valve Replacement Surgeries
Status: NOT_YET_RECRUITING
Conditions: Cardiac Valve Disease
Interventions: DRUG: Intrathecal morphine or dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Peritoneal Lavage With Clindamycin-Gentamicin Solution & Oncologic Outcome
Status: COMPLETED
Conditions: Colorectal Tumors
Interventions: PROCEDURE: Antibiotic lavage|PROCEDURE: Normal saline lavage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transversus Abdominus Plane Block in Living Donor Hepatectomy
Status: COMPLETED
Conditions: Living Donor Hepatectomy
Interventions: DEVICE: surgically inserted Transversus abdominus plane catheter|DRUG: Intravenous morphine|DRUG: Bupevecaine|DRUG: Dexmedetomedine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Surgery With or Without Preoperative Chemotherapy in Treating Patients With Resectable Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: cisplatin|DRUG: docetaxel|DRUG: gemcitabine hydrochloride|DRUG: ifosfamide|DRUG: mitomycin C|DRUG: paclitaxel|DRUG: vinblastine sulfate|DRUG: vinorelbine tartrate|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Palliative Therapy With or Without Chemotherapy in Treating Patients With Malignant Mesothelioma
Status: UNKNOWN
Conditions: Malignant Mesothelioma
Interventions: DRUG: cisplatin|DRUG: mitomycin C|DRUG: vinblastine sulfate|DRUG: vinorelbine tartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effect of Inhibition of B7-mediated Costimulation on Allergic Airway Inflammation in Mild Atopic Asthmatics
Status: COMPLETED
Conditions: Atopic Asthma
Interventions: DRUG: abatacept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Brimonidine Tartrate for Pterygium Surgery
Status: UNKNOWN
Conditions: Pterygium|Subconjunctival Hemorrhage
Interventions: DRUG: Brimonidine Tartrate 0.15% Oph Soln|DRUG: Brimonidine Tartrate 0.025% Oph Soln
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Long-term Extension Study of Ligelizumab in Food Allergy
Status: ACTIVE_NOT_RECRUITING
Conditions: Food Allergy
Interventions: DRUG: Ligelizumab 120 mg|DRUG: Ligelizumab 240 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Driving Performance After Middle of the Night Administration of 3.5 mg Zolpidem Tartrate Sublingual Tablet
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: zopiclone|DRUG: zolpidem tartrate sublingual tablet|DRUG: Placebo (sublingual tablet)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Adult Outpatients With Opioid Dependence Transitioned From a Daily SL Buprenorphine to Probuphine® Subdermal Implants
Status: COMPLETED
Conditions: Opioid Dependence
Interventions: DRUG: sublingual buprenorphine tablets|DRUG: Buprenorphine implant|DRUG: placebo implants|DRUG: sublingual placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Precision Thyroid Cancer Surgery With Molecular Fluorescent Guided Imaging
Status: COMPLETED
Conditions: Papillary Thyroid Cancer|Lymph Node Metastases
Interventions: DRUG: IV adminstration of EMI-137|DEVICE: Multispectral Fluorescence Reflectance Imaging|DEVICE: Spectroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prevention of Opioid Use Disorder After Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Opioid-use Disorder|Opioid Dependence|Opioid Use
Interventions: BEHAVIORAL: Discharge Order Sets|BEHAVIORAL: Pharmacist-Led Discharge Counseling and Communication|BEHAVIORAL: Post-discharge Pain Management Follow-up|BEHAVIORAL: Patient Engagement Pain Management App
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase II Study of Sunitinib Versus Dacarbazine in the Treatment of Patients With Metastatic Uveal Melanoma
Status: COMPLETED
Conditions: Metastatic Uveal Melanoma
Interventions: DRUG: Dacarbazine|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple-Ascending Dose in Japanese Patients Bridging Study
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rodatristat Ethyl 300 mg BID|DRUG: Rodatristat Ethyl 600 mg BID|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Binaural Beats on Pain Perception and Analgesic Medication Use in Patients Suffering From Chronic Pain
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DEVICE: Music with Binaural Beats|DEVICE: Music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Exploration Study of Almonertinib for EGFRm NSCLC Patients With Brain/Leptomeningeal Metastasis (ARTISTRY)
Status: UNKNOWN
Conditions: NSCLC|Brain Metastases|Leptomeningeal Metastasis
Interventions: DRUG: almonertinib|DRUG: LM-first line treatment|DRUG: LM-second line treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of RD06-03 CART Cell Injection in Patients With R/R Acute B-lymphoblastic Leukemia
Status: NOT_YET_RECRUITING
Conditions: B Lymphoblastic Leukemia/Lymphoma
Interventions: DRUG: RD06-03 cell injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Tension Headache Using Soft Tissue Techniques VS Vagus Stimulation Techniques.
Status: UNKNOWN
Conditions: Chronic Tension-Type Headache|Episodic Tension-Type Headache
Interventions: OTHER: Suboccipital inhibition|OTHER: Ischemic pressure|OTHER: Passive stretching|OTHER: Diaphragmatic breathing exercice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Esophageal Fully Covered Metal Stents in Caustic Strictures Study
Status: COMPLETED
Conditions: Refractory Benign Esophageal Strictures Caused by Caustic Ingestion
Interventions: DEVICE: Metal Stent (WallFlex™ Esophageal RX)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Albumin Therapy With Standard Medical Treatment (SMT) as Compared to Standard Medical Treatment (SMT) in Improving Patient Survival and Immune Modulation in Patients With Acute on Chronic Liver Failure (ASIA Trial).
Status: UNKNOWN
Conditions: Acute on Chronic Liver Failure
Interventions: BIOLOGICAL: Albumin|OTHER: Standard Medical Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UCN-01 and Prednisone in Treating Patients With Solid Tumors or Lymphoma
Status: COMPLETED
Conditions: Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: 7-hydroxystaurosporine|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Anlotinib in Patients With Metastatic Pheochromocytoma or Paraganglioma
Status: COMPLETED
Conditions: Malignant Adrenal Gland Pheochromocytoma|Malignant Paraganglioma|Pheochromocytoma, Metastatic|Paraganglioma, Malignant|Paraganglioma, Extra-Adrenal
Interventions: DRUG: anlotinib hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Controlled Release Formulations of CE-224,535 Against the Immediate Release Formulation in Normal Volunteers
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: suspension IR|DRUG: CR 1|DRUG: CR 2|DRUG: CR 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cancer as a complicATion in reCipients of Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Disease iNdiCation trEated in FRance and Canada?
Status: NOT_YET_RECRUITING
Conditions: Autoimmune Diseases
Interventions: OTHER: Observational cohort
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-181)(COMPLETED)
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: MK0966, rofecoxib|DRUG: Comparator: valdecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Fascia Iliaca Compartment Block and Pericapsular Nerve Group Block for Hip Fracture Pain Control
Status: COMPLETED
Conditions: Hip Fractures|Analgesia|Nerve Blocks
Interventions: PROCEDURE: Fascia iliaca compartment block|PROCEDURE: Pericapsular nerve group block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Trandolapril 4 mg Tablets of Dr. Reddy's Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Trandolapril|DRUG: Mavik
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Triticum Aestivum on Appetite, Ghrelin, Leptin, Adiponectin Hormonal Axis in Patients With Obesity
Status: RECRUITING
Conditions: Obesity|Leptin Deficiency|Ghrelin|Adiponectin
Interventions: DRUG: Triticum Aestivum|DRUG: Placebo (calcined magnesia)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bright Light: A Novel Treatment for Anxiety
Status: COMPLETED
Conditions: Anxiety|Depression|Sleep
Interventions: DEVICE: Litebook Bright Light Box|DEVICE: Litebook inactivated negation ion generator (the placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Protein Hydrolysates on HbA1c Levels in Pre-diabetics
Status: TERMINATED
Conditions: PreDiabetes
Interventions: DIETARY_SUPPLEMENT: Plant-based Protein Hydrolysate 1|DIETARY_SUPPLEMENT: Plant-based Protein Hydrolysate 2|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) 180mg, Ezetimibe 10mg, and Atorvastatin 20 mg Triplet Therapy in Patients With Elevated LDL-C
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Bempedoic acid 180mg|DRUG: Ezetimibe 10mg|DRUG: Atorvastatin 20mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Massive Rotator Cuff Tear Reconstruction
Status: ACTIVE_NOT_RECRUITING
Conditions: Rotator Cuff Tear Arthropathy
Interventions: PROCEDURE: Bridging Rotator Cuff Reconstruction|PROCEDURE: Superior Capsular Reconstruction|DEVICE: GRAFTJACKET™ allograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prime-Boost Dose Scheduling Trial for Human GM-CSF Gene Transduced Irradiated Prostate Allogeneic Cancer Vaccine (Allogeneic Prostate GVAX®) in Patients With Hormone-Refractory Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: Immunotherapy allogeneic GM-CSF secreting cellular vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Hypnosis and Virtual Reality During Pre and Postoperative Cardiovascular Surgery.
Status: UNKNOWN
Conditions: Thoracic Surgery|Pain, Postoperative|Anxiety|Fatigue
Interventions: BEHAVIORAL: Hypnosis (Hypn)|BEHAVIORAL: Virtual reality (VR)|BEHAVIORAL: Virtual reality hypnosis (VRH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Menorrhagia in Women With Thrombocytopenia Using Platelets or Platelets and Hormones
Status: TERMINATED
Conditions: Aplastic Anemia|Menorrhagia|Amenorrhea
Interventions: DRUG: Lo-Ovral Oral Contraceptive Pills|DRUG: Placebo - sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety and Efficacy of a Second Course of TPX-100 in Subjects Who Previously Received TPX-100 for Patellar Osteoarthritis Involving Both Knees
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: TPX-100 200 mg 4 times weekly for 4 weeks|DRUG: TPX-100 200 mg 4 times weekly for 4 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Method Comparison/User Evaluation of the i-SENS Self-Monitoring Blood Glucose / β-Ketone System
Status: TERMINATED
Conditions: Diabetes
Interventions: DEVICE: CareSens PRO GK Blood Glucose/b-Ketone Monitoring system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Eradication of Antibiotic-resistant Bacteria Through Antibiotics and Fecal Bacteriotherapy
Status: UNKNOWN
Conditions: Intestinal Colonization With Multidrug-resistant Bacteria
Interventions: DRUG: Colistin|DRUG: Neomycin|DRUG: Fecal microbiota transplantation (FMT)|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of MySmile App for Improving the Oral Health of Secondary School Children:
Status: NOT_YET_RECRUITING
Conditions: Oral Disease|Gingival Diseases
Interventions: OTHER: MySmile app|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Ledipasvir/Sofosbuvir Fixed-Dose Combination and Sofosbuvir + Ribavirin for Subjects With Chronic Hepatitis C Virus (HCV) and Inherited Bleeding Disorders
Status: COMPLETED
Conditions: Chronic HCV Infection
Interventions: DRUG: LDV/SOF|DRUG: SOF|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Apixaban in Patients With Atrial Fibrillation, Not Caused by a Heart Valve Problem, Who Are at Risk for Thrombosis (Blood Clots) Due to Having Had a Recent Coronary Event, Such as a Heart Attack or a Procedure to Open the Vessels of the Heart
Status: COMPLETED
Conditions: Acute Coronary Syndromes
Interventions: DRUG: Apixaban|DRUG: vitamin K antagonist|DRUG: Acetylsalicylic acid|OTHER: Acetylsalicylic acid placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Sintilimab Combined With Metformin in First-Line Chemotherapy Refractory Advanced NSCLC Patients
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: Sintilimab|DRUG: Metformin Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sufentanil for Anesthesia Induction in Continuous Remifentanil Anesthesia
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Dose Safety, Tolerability, Pharmacokinetic and Food Effect Study of KVD900 in Healthy Volunteers
Status: COMPLETED
Conditions: Hereditary Angioedema
Interventions: DRUG: KVD900|DRUG: Placebo to KVD900
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Patient Education at Dismissal After Surgical Procedure
Status: WITHDRAWN
Conditions: Wound Infection Post-Traumatic|Wound Infection|Wound Complication|Wound Breakdown|Wound Open
Interventions: BEHAVIORAL: Enhanced Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Functional Effects and Impact on Motor Neuronal Activity of Early and Intensive Motrice (Hand and Arm Bimanual Intensive Therapy Including Lower Extremities: HABIT-ILE) Reeducation in Children With Pre-school Bilateral Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: MRI|OTHER: Electro-Encephalography-High Density|OTHER: 3D and EMG analysis|OTHER: care and classic activities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Immediate Angioplasty For Acute Ischemic Stroke With Severe Intracranial Atherosclerotic Stenosis
Status: NOT_YET_RECRUITING
Conditions: Stroke, Acute Ischemic
Interventions: PROCEDURE: Immediate angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Human Cells (hMSC)in Patients With Idiopathic Pulmonary Fibrosis Via Intravenous Delivery (AETHER)
Status: TERMINATED
Conditions: Idiopathic Pulmonary Fibrosis (IPF)
Interventions: BIOLOGICAL: Allogeneic Adult Human Mesenchymal Stem Cells (hMSCs)|BIOLOGICAL: matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of 3D Surface Scanning for Virtual-CT Based Radiation Therapy Treatment Planning
Status: RECRUITING
Conditions: Hematopoietic and Lymphatic System Neoplasm|Malignant Solid Neoplasm
Interventions: OTHER: Electronic Health Record Review|PROCEDURE: Three-Dimensional Imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy Study of Dexamethasone Versus Ranibizumab in Patients With Diabetic Macular Edema
Status: COMPLETED
Conditions: Macular Edema
Interventions: DRUG: dexamethasone Intravitreal Implant|DRUG: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Lenalidomide With and Without Dexamethasone in Japanese Subjects With Previously Treated Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: lenalidomide|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ALX148, Rituximab and Lenalidomide for the Treatment of Indolent and Aggressive B-cell Non-Hodgkin Lymphoma
Status: RECRUITING
Conditions: Aggressive B-Cell Non-Hodgkin Lymphoma|Ann Arbor Stage III Grade 2 Follicular Lymphoma|Ann Arbor Stage III Grade 3 Follicular Lymphoma|Ann Arbor Stage III Marginal Zone Lymphoma|Ann Arbor Stage IV Grade 1 Follicular Lymphoma|Ann Arbor Stage IV Grade 2 Follicular Lymphoma|Ann Arbor Stage IV Grade 3 Follicular Lymphoma|Ann Arbor Stage IV Marginal Zone Lymphoma|Composite Lymphoma|Indolent B-Cell Non-Hodgkin Lymphoma|Refractory Aggressive B-Cell Non-Hodgkin Lymphoma|Refractory Follicular Lymphoma|Refractory Grade 3b Follicular Lymphoma|Refractory High Grade B-Cell Lymphoma|Refractory Mantle Cell Lymphoma|Refractory Marginal Zone Lymphoma|Refractory Primary Mediastinal (Thymic) Large B-Cell Lymphoma|Refractory Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma|Refractory Transformed Marginal Zone Lymphoma to Diffuse Large B-Cell Lymphoma|Richter Syndrome
Interventions: DRUG: CD47 Antagonist ALX148|DRUG: Lenalidomide|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Midazolam and Zolpidem as Oral Premedication in Children
Status: COMPLETED
Conditions: Parental/Caregiver Anxiety|Child's Anxiety
Interventions: DRUG: zolpidem|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Pulmonary Rehabilitation and Airways Clearance Techniques in the Multidisciplinary Management of Non CF Bronchiectasis
Status: UNKNOWN
Conditions: Non-cystic Fibrosis Bronchiectasis
Interventions: OTHER: Pulmonary Rehabilitation and Chest Physiotherapy|OTHER: Pulmonary Rehabilitation|OTHER: Chest Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Optimizing Smoking Cessation for People With HIV/AIDS Who Smoke
Status: COMPLETED
Conditions: Smoking|HIV
Interventions: DRUG: Varenicline|BEHAVIORAL: Positively Smoke Free|DRUG: Placebo|BEHAVIORAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Effects of Modulating Circulating Ketone Bodies With 1,3-butanediol
Status: COMPLETED
Conditions: Heart Failure
Interventions: DIETARY_SUPPLEMENT: 1,3-Butanediol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: ENhancing Exercise With LIGHT to Improve Functioning in PAD
Status: RECRUITING
Conditions: Peripheral Artery Disease|Peripheral Vascular Disease|Aging|Walking, Difficulty
Interventions: DEVICE: Far red light therapy|DEVICE: Sham light therapy|BEHAVIORAL: Home-based walking exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MILTA vs Placebo Use Comparison for the Management of Pain Related to Perineal Scars Following Delivery
Status: RECRUITING
Conditions: Perineal Scars|Delivery Complication|Episiotomy|Pain|Treatment
Interventions: OTHER: MILTA probe|OTHER: placebo probe
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare Effects of Intensive Versus Conventional Lipid-lowering Therapy in Patients With Severe Atherosclerotic Renal Artery Stenosis Undergoing Stent Placement
Status: COMPLETED
Conditions: Renal Artery Obstruction|Stents|Lipids|Glomerular Filtration Rate|Blood Pressure
Interventions: DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Ibuprofen Versus Ketorolac in Bariatric Surgery
Status: NOT_YET_RECRUITING
Conditions: Postoperative Pain|Bariatric Surgery Candidate
Interventions: DRUG: Ketorolac group|DRUG: Ibuprofen group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Saxenda: Underlying Mechanisms and Clinical Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: DRUG: liraglutide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (LUCERNE)
Status: COMPLETED
Conditions: Wet Macular Degeneration
Interventions: DRUG: Faricimab|DRUG: Aflibercept|PROCEDURE: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability and Pharmacokinetics of PBTZ169 in Multiple Dosing
Status: COMPLETED
Conditions: Tuberculosis, Pulmonary
Interventions: DRUG: PBTZ169|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Angiography Study of BioNIR Drug Eluting Stent System (NIREUS)
Status: COMPLETED
Conditions: Coronary Artery Stenosis
Interventions: DEVICE: BioNIR|DEVICE: Resolute
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comfort and Antimicrobial Efficacy of Chlorhexidine vs Betadine for Intravitreal Injections
Status: UNKNOWN
Conditions: Age-related Macular Degeneration|Diabetic Vascular Diseases|Proliferative Retinopathy|Retina Vein Occlusion
Interventions: DRUG: Chlorhexidine|DRUG: Povidine-Iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of NMES+ on Hamstring Lesion (3a/3b)
Status: NOT_YET_RECRUITING
Conditions: Hamstring Injury|Muscle Rupture|Hamstring Sprain
Interventions: DEVICE: NMES+|PROCEDURE: Rehab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transplantation of Pancreatic Islets in Patients With Type 1 Diabetes Mellitus and Functional Kidney Graft
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus
Interventions: PROCEDURE: human pancreatic islet transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study Evaluating the Safety and Efficacy of IDP-107 in Patients With Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Low Strength IDP-107|DRUG: High Strength IDP-107|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of an Inactivated Non-adjuvanted A(H1N1)v Influenza Vaccine in Pregnant Women
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Non-adjuvanted A(H1N1)v influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Online Videos and New Feeding Content to Enhance a Current EFNEP Program
Status: COMPLETED
Conditions: Obesity, Childhood
Interventions: BEHAVIORAL: Nutrition program with in-person parental feeding content|BEHAVIORAL: Nutrition program with online parental feeding content
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Early and Standard Intervention With 120,000 Units of PROCRIT (Epoetin Alfa) Every Three Weeks in Patients Receiving Chemotherapy
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: PROCRIT (Epoetin alfa)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Tisseel as an Adjunct to Traditional Hemostasis After Redo Cardiac Surgery
Status: COMPLETED
Conditions: Hemorrhage
Interventions: PROCEDURE: Spray Fibrin Sealant|PROCEDURE: Traditional Hemostasis and chest Closure Routine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Amoxicilline/Clavulanic Acid in Patients Affected by Tic Disorder Colonized by Group A Streptococcus
Status: UNKNOWN
Conditions: Tic Disorders
Interventions: DRUG: Amoxicillin-Potassium Clavulanate Combination|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Berries, Inflammation, and Gut Microbiome
Status: ACTIVE_NOT_RECRUITING
Conditions: Overweight or Obesity|Healthy
Interventions: DIETARY_SUPPLEMENT: Mixed berries|DIETARY_SUPPLEMENT: FOS|DIETARY_SUPPLEMENT: Control|DIETARY_SUPPLEMENT: Combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Pilot, Multi-Center, Patient Preference Study Comparing Two Clindamycin/Benzoyl Peroxide Gels.
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: clindamycin 1% / benzoyl peroxide 5% gel pump|DRUG: clindamycin 1% / benzoyl peroxide 5% tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Ifetroban in Hepatorenal Syndrome Patients
Status: COMPLETED
Conditions: Hepatorenal Syndrome
Interventions: DRUG: Ifetroban Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Detection of Atrial Fibrillation in TIA
Status: UNKNOWN
Conditions: Atrial Fibrillation|Transient Ischemic Attack
Interventions: DEVICE: 24-h Holter monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Development of Interstitial Lung Disease (ILD) in Patients With Severe SARS-CoV-2 Infection (COVID-19)
Status: UNKNOWN
Conditions: Covid-19|Pulmonary Fibrosis
Interventions: DIAGNOSTIC_TEST: Pulmonary function tests|DIAGNOSTIC_TEST: Imaging|BIOLOGICAL: Blood sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immediate Intra Uterine Isemination (IUI) Versus Expectant Management in Postoperative Endometriosis Patients
Status: TERMINATED
Conditions: Endometriosis|Infertility
Interventions: OTHER: controlled ovarian stimulation with gonadotropins + intrauterine insemination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propellers Flaps for Meningomylocele Defects
Status: COMPLETED
Conditions: Meningocele|Meningomyelocele
Interventions: PROCEDURE: Freestyle pedicled perforators propellers flaps for meningomyelocele defects
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Carbon-14-Labeled [14C]-LY3549492 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Male
Interventions: DRUG: [14C]-LY3549492|DRUG: LY3549492|DRUG: [14C]-LY3549492
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE