pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Phase 3, Long-term, Extension Study of TVP-1012 (1 mg) in Early Parkinson's Disease Participants
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: TVP-1012 1mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Cream for Treatment of Dermatitis in Patients Whith Breast Cancer
Status: COMPLETED
Conditions: DERMATITIS INDUCED BY RADIOTHERAPY IN PATIENTS WHITH BREAST CANCER
Interventions: COMBINATION_PRODUCT: Cosmetic cream (Alantel (R): aloe vera, chamomile and thime)|COMBINATION_PRODUCT: Usual treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: ALK37-003: A Study of RDC-1036 (ALKS 37) in Adults With Opioid-induced Constipation (OIC)
Status: COMPLETED
Conditions: Opioid-induced Constipation
Interventions: DRUG: RDC-1036 (ALKS 37)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vestibular Versus Sublingual Route of AIT Tablets
Status: COMPLETED
Conditions: Hypersensitivity
Interventions: DRUG: tree 12 SQ-Bet|DRUG: GRASS 2800 BAU|DRUG: RAGWEED 12 AMB A 1-U|DRUG: HDM 12 SQ-HDM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Electrical Stimulation Following Total Hip Arthroplasty
Status: COMPLETED
Conditions: Deep Vein Thrombosis|Total Hip Arthroplasty
Interventions: DEVICE: Neuromuscular Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Designed to Evaluate ODSH in Subjects With Exacerbations of COPD
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Open-Label|DRUG: Placebo Comparator: Placebo-Control Arm 0.9% Sodium Chloride|DRUG: ODSH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endothelial Dysfunction and Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Trinitrin|DRUG: Neosynephrine 10% collyrium|DRUG: Iontophoresis with acetylcholine delivery|DEVICE: Dynamic Vessel Analyzer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tranexamic Acid in Sleeve Gastrectomy
Status: COMPLETED
Conditions: Tranexamic Acid Adverse Reaction
Interventions: OTHER: Transamine 200mg iv
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing the Baerveldt and Paul Glaucoma Drainage Devices and Their Effects on the Corneal Endothelium
Status: RECRUITING
Conditions: Glaucoma
Interventions: DEVICE: Surgery/implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Manual Therapy on Autonomic Nervous System's Balance, Pain and Well-being in Patients With Fibromyalgia.
Status: UNKNOWN
Conditions: Fibromyalgia, Manual Therapy
Interventions: OTHER: Active mobilization of soft tissues|OTHER: Passive mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of JNJ-67953964 on Gastric Mucosal Integrity in Healthy Male and Female Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-67953964|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Remote Ischemic Preconditioning on Kidney Function in Patients Undergoing Partial Nephrectomy
Status: COMPLETED
Conditions: Renal Neoplasm|Renal Injury
Interventions: PROCEDURE: Remote Ischemic Preconditioning|PROCEDURE: Sham control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Insulin Detemir or Insulin Glargine as Add on to Oral Antidiabetic Drugs in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin detemir|DRUG: insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Pain Neuroscience Education and Strength Training in Fibromyalgia
Status: ACTIVE_NOT_RECRUITING
Conditions: Fibromyalgia
Interventions: PROCEDURE: PAIN NEUROSCIENCE EDUCATION AND STRENGTH TRAINING|PROCEDURE: USUAL CARE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation for Digital Acupuncture Manipulation Therapeutic Instrument
Status: UNKNOWN
Conditions: Cervical Spondylosis
Interventions: DEVICE: Digital Acupuncture Manipulation Therapeutic Instrument|OTHER: Manual Acupuncture|OTHER: Sham Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Inflammatory Markers in Adult Patients With Asthma Associated With Allergic Rhinitis Receiving Montelukast Therapy (0476-366)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: MK0476, montelukast sodium / Duration of Treatment: 12 Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral T7 Oral Testosterone in Man
Status: COMPLETED
Conditions: Healthy Males|Male Contraceptive
Interventions: DRUG: First Intervention (7 days)|OTHER: First Washout (7 days)|DRUG: Second Intervention (7 days)|DRUG: Third Intervention (7 days)|OTHER: Second wash-out period
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lidocaine 5% Patch (Lidoderm) for the Prevention of Acute and Chest Pain Following Robotic Valve Surgery
Status: COMPLETED
Conditions: Perioperative Chest Pain
Interventions: DRUG: Lidoderm 5 % Topical Patch|DRUG: Placebo patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity Study of the Recombinant Human Papillomavirus Virus Type 6/11 Bivalent Vaccine
Status: ACTIVE_NOT_RECRUITING
Conditions: Condylomata Acuminata
Interventions: BIOLOGICAL: low dosage HPV Vaccine(1:1)|BIOLOGICAL: low dosage HPV Vaccine(1:2)|BIOLOGICAL: high dosage HPV Vaccine(1:1)|BIOLOGICAL: Hepatitis E vaccine,Hecolin®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Safety and Efficacy of Lacosamide Added to the Patients Current Therapy in Patients Aged 1 Month to Less Than 18 Years Old With Epilepsy Syndromes Associated With Generalized Seizures.
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Lacosamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Repeated Administration of a 200-mcg Dose of IPP-201101 Plus Standard of Care in Patients With Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Lupus Erythematosus, Systemic
Interventions: DRUG: IPP-201101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Hyperbaric Oxygen Therapy for Acceleration Recovery After Anterior Cruciate Ligament Reconstruction(ACLR)
Status: NOT_YET_RECRUITING
Conditions: Anterior Cruciate Ligament Reconstruction
Interventions: DEVICE: hyperbaric oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography in Monitoring Treatment Response in Women With Newly Diagnosed Breast Cancer
Status: WITHDRAWN
Conditions: Adult Women With a New Diagnosis of Invasive Breast Cancer (Have Not Undergone Treatment)
Interventions: OTHER: 3'-deoxy-3'-[18F]fluorothymidine|PROCEDURE: Positron Emission Tomography/computed tomography|RADIATION: FLT-PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pegylated Liposomal Doxorubicin Hydrochloride, Bortezomib, Cyclophosphamide, and Dexamethasone in Treating Patients With Multiple Myeloma
Status: TERMINATED
Conditions: Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma
Interventions: DRUG: cyclophosphamide|DRUG: pegylated liposomal doxorubicin hydrochloride|DRUG: bortezomib|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NF-κB Inhibition in Amyotrophic Lateral Sclerosis
Status: UNKNOWN
Conditions: ALS
Interventions: DRUG: Withania somnifera|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bespoke vs Standard Instrumentation in TKR
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Patient specific instrumentation|PROCEDURE: Conventional|DEVICE: Patient specific instrumentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dance and Movement Therapy in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Negative Symptoms in Schizophrenia|Disabilities Mental|Dance Therapy
Interventions: OTHER: Dance and Movement Therapy (DMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Intravitreal Triamcinolone Acetonide Versus Intravitreal Bevacizumab for Refractory Diabetic Macular Edema (IBEME Study)
Status: UNKNOWN
Conditions: Diabetic Macular Edema
Interventions: PROCEDURE: Intravitreal Injection of 1,5 mg of bevacizumab|PROCEDURE: Intravitreal injection of 4 mg of Triamcinolone acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Study of IRX4204 With Erlotinib in Previously Treated Advanced NSCLC
Status: SUSPENDED
Conditions: Lung Cancer, Nonsmall Cell
Interventions: DRUG: IRX4204|DRUG: erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Mesiodistal Root Angulation Without Radiographic Guidance Versus CBCT Guidance: A Cross Sectional Study.
Status: RECRUITING
Conditions: Mesiodistal Root Angulation - Radiographic Guidance - CBCT Guidance - Assessment
Interventions: DEVICE: OrthoAnalyzer™ software
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ultrafast Ultrasound for the Functional Assessment of the Diaphragm
Status: RECRUITING
Conditions: Diaphragm Dysfunction
Interventions: DIAGNOSTIC_TEST: Transdiaphragmatic pressure measurement|DIAGNOSTIC_TEST: EMG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Assess the Efficacy and Safety of Iovera®° System in Subjects With Upper Extremity Spasticity
Status: RECRUITING
Conditions: Spasticity, Cerebral or Spinal Condition
Interventions: DEVICE: iovera° system|DEVICE: sham iovera° system treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Cassia Fistula + Senna Alexandrina Miller in the Chronic Functional Constipation Treatment.
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: SENNA+CASSIA|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short-time Intervention in Post-Covid Syndrome Syndrome (SIPCOV): A Pragmatic Randomised Controlled Trial
Status: COMPLETED
Conditions: COVID-19
Interventions: BEHAVIORAL: Rehabilitation based on CBT principles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Guardix-solution for the Prevention of Postoperative Intestinal Adhesion and Intestinal Obstruction After Laparoscopic Pelvic Cavity Surgery
Status: COMPLETED
Conditions: Prostate Cancer|Postoperative Adhesion
Interventions: DRUG: hyaluronic acid-carboxymethylcellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess RXC004 Efficacy in Advanced Solid Tumours After Progression on Standard of Care (SoC) Therapy (PORCUPINE2)
Status: COMPLETED
Conditions: Advanced Solid Tumours
Interventions: DRUG: RXC004|DRUG: RXC004|DRUG: RXC004|BIOLOGICAL: Denosumab|BIOLOGICAL: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Increasing Physical Activity Among Breast Cancer Survivors With Depression
Status: COMPLETED
Conditions: Depression|Physical Activity|Breast Cancer
Interventions: BEHAVIORAL: Print-based education|DEVICE: Fitbit|BEHAVIORAL: Active Living counseling|OTHER: Facility Access
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of FF-10850 Topotecan Liposome Injection in Advanced Solid Tumors Including Merkel Cell Carcinoma
Status: RECRUITING
Conditions: Advanced Solid Tumors|Merkel Cell Carcinoma
Interventions: DRUG: FF-10850 Topotecan Liposome Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study on Device-assisted Mobilisation of Critically Ill Patients
Status: RECRUITING
Conditions: Muscle Weakness|Critical Illness
Interventions: DEVICE: Device-assisted mobilisation with the sit/stand stabilizer Liana
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: KEYS: Study Comparing Clinical Health Outcomes of Telithromycin Versus Azithromycin in Outpatients With Community-acquired Lower Respiratory Tract Infections
Status: TERMINATED
Conditions: Respiratory Tract Infections|Chronic Bronchitis|Pneumonia
Interventions: DRUG: Telithromycin|DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics Study of SyB C-1101 in Patients With Recurrent/Relapsed or Refractory Myelodysplastic Syndrome (MDS)
Status: COMPLETED
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: SyB C-1101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Stereotactic Ablative Radiotherapy for Metastatic Lymphadenopathy
Status: UNKNOWN
Conditions: Metastasis of Malignant Neoplasm to Lymph Node
Interventions: RADIATION: Stereotactic ablative radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Individualized Behavioral Intervention of Smartphone App in the Treatment of Type 2 Diabetes Mellitus
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: conventional treatment|OTHER: Maltose app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study To Observe Safety And Concentrations Of PF-05297909 And Proteins In Both Blood And Cerebrospinal Fluid After A Single Dose Of PF-05297909 In Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-05297909 25 mg|DRUG: PF-05297909 100 mg|DRUG: PF-05297909 250 mg|DRUG: PF-05297909 525 mg|DRUG: PF-05297909 525 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial Of Sunitinib In Advanced Non-Clear Cell Type Renal Cell Carcinoma
Status: UNKNOWN
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of RapidPulseTM Aspiration System as Frontline Approach for Patients With Acute Ischemic Stroke
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: DEVICE: RapidPulseTM Aspiration System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Study of Efficacy and Safety of MAS825 in Patients With COVID-19
Status: COMPLETED
Conditions: COVID-19 Pneumonia, Impaired Respiratory Function
Interventions: DRUG: MAS825|OTHER: Placebo|DRUG: Standard of Care (SoC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Use of Tranexamic Acid in Tibial Osteotomies
Status: RECRUITING
Conditions: Monocompartimental Tibiofemoral Osteoarthritis|Osteoarthritis
Interventions: DRUG: Tibial osteotomy with Tranexamic acid|PROCEDURE: Tibial osteotomy without Tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Confounding Factors in the Detection of Intracranial Hemorrhage With the Infrascanner
Status: COMPLETED
Conditions: Ischemic Stroke|Brain Tumor|Brain Surgery|Intracranial Hemorrhage|Headache|Head Trauma
Interventions: DEVICE: Infrascanner
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study Comparing the Efficacy of Amlodipine Besylate/Benazepril Versus Amlodipine in the Treatment of Severe Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: amlodipine besylate/benazepril hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Peginterferon Alfacon-2 to Treat Chronic Hepatitis B Virus Infection
Status: COMPLETED
Conditions: Chronic Hepatitis B Virus Infection
Interventions: DRUG: Peginterferon Alfacon-2|DRUG: Peginterferon Alfacon-2 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Support in Patients With Rheumatoid Arthritis
Status: TERMINATED
Conditions: RHEUMATOID ARTHRITIS
Interventions: BIOLOGICAL: Immune ablation and hematopoietic stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Repair of Spigelian Hernia in a Cohort of Patients
Status: COMPLETED
Conditions: Spigelian Hernia
Interventions: PROCEDURE: Fixation free Spigelian hernia repair with tentacle mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lung Ultrasound for Infants' Swallowing Disorders
Status: UNKNOWN
Conditions: Cerebral Palsy|Pediatric Neurological Disorder|Developmental Disability
Interventions: DIAGNOSTIC_TEST: Lung Ultrasound (LUS)-monitored feeding trial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Multi-Center Study to Evaluate the Efficacy and Safety of Sildenafil Cream (3.6%) in Premenopausal Patients With Female Sexual Arousal Disorder
Status: UNKNOWN
Conditions: Female Sexual Arousal Disorder
Interventions: DRUG: Sildenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Clonidine Hydrochloride Topical Gel, vs Clonidine Hydrochloride Gel Comparator to Treat Painful Diabetic Neuropathy
Status: COMPLETED
Conditions: Painful Diabetic Neuropathy|Diabetic Neuropathy|Neuropathy
Interventions: DRUG: Clonidine Hydrochloride Topical Gel, 0.1%|DRUG: Clonidine Hydrochloride Gel Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Study on Comparing the Efficacy of Foley Catheter and Extraamniotic Saline Infusion for Labor Induction
Status: COMPLETED
Conditions: Cervical Ripening|Labor, Induced
Interventions: PROCEDURE: Foley catheter only|PROCEDURE: Extraamniotic saline infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Analysis of Comparison of CAMS（Chinese Academy of Medical Sciences）-2005 Trial and CAMS-2009 Trial for Pediatric Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia, Pediatric
Interventions: OTHER: Risk-stratified therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis With(J-M-Pa-Z) (NC-001)
Status: COMPLETED
Conditions: Pulmonary Tuberculosis
Interventions: DRUG: PA-824|DRUG: Pyrazinamide|DRUG: TMC207|DRUG: Rifafour|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Effect of Salbutamol and Ipratropium Bromide in Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Salbutamol|DRUG: ipratropium bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Methylnaltrexone Bromide (MNTX) in Participants With Advanced Pancreatic Cancer
Status: WITHDRAWN
Conditions: Pancreatic Cancer
Interventions: DRUG: Methylnaltrexone bromide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Veliparib as a Single Agent or in Combination With Chemotherapy in Subjects With Solid Tumors
Status: COMPLETED
Conditions: Breast Cancer|Ovarian Cancer|Colon Cancer|Lung Cancer|Gastric Cancer|Solid Tumors
Interventions: DRUG: Veliparib|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementing HEARTS in Guatemala
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Hypertension|Cardiovascular Diseases
Interventions: OTHER: Integrated Diabetes and Hypertension Primary Care Model|OTHER: Integrated Diabetes and Hypertension Primary Care Model - Providers
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of Ranolazine and Dronedarone When Given Alone and in Combination in Patients With Paroxysmal Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Ranolazine|DRUG: Dronedarone|DRUG: Ranolazine placebo|DRUG: Dronedarone placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Brain Oscillation-synchronized Stimulation of the Frontal Cortex in Major Depressive Disorder
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DEVICE: Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Elotuzumab for the Treatment of JAK2-Mutated Myelofibrosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelofibrosis Transformation in Essential Thrombocythemia|Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase|Primary Myelofibrosis
Interventions: BIOLOGICAL: Elotuzumab|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Activation Energy Serum (AES) Versus Placebo in Persistent Asthma.
Status: UNKNOWN
Conditions: Mild to Moderate Persistent Asthma
Interventions: DIETARY_SUPPLEMENT: Activation Energy Serum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label Extension Trial of HZNP-HZN-825-301 in Adult Participants With Diffuse Cutaneous Systemic Sclerosis (Diffuse Cutaneous SSc)
Status: ENROLLING_BY_INVITATION
Conditions: Diffuse Cutaneous Systemic Sclerosis|Sclerosis, Systemic
Interventions: DRUG: HZN-825
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wellbutrin XL for Dysthymic Disorder
Status: COMPLETED
Conditions: Dysthymic Disorder
Interventions: DRUG: bupropion XL|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enalapril Folic Acid Tablets Combined With CCB or Diuretic to Prevent Stroke in Patients With Type H Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Enalapril Folic Acid Tablets Combined With amlodipine|DRUG: Enalapril Folic Acid Tablets Combined With hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurobehavioral Intervention as a Novel Treatment Approach for Emotion-Regulatory Deficits
Status: COMPLETED
Conditions: Anxiety|Depression
Interventions: BEHAVIORAL: Computerized Neurobehavioral Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 1/2 Study of VSLI Plus Rituximab in Patients With Relapsed and/or Refractory NHL
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma|Diffuse Large B-cell Lymphoma|Mantle Cell Lymphoma
Interventions: DRUG: Vincristine Sulfate Liposome Injection plus rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Status in Lower Extremity Joint Replacement Surgery Patients
Status: WITHDRAWN
Conditions: Hypovitaminosis D
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Closing the Loop for 36 Hours in Adolescents With Type 1 Diabetes: Evaluation of Reduced Meal Bolusing
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: Closed-loop insulin delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ticagrelor Monotherapy in PAtients Treated With New-generation Drug-eluting Stents for Acute Coronary Syndrome; T-PASS Trial
Status: RECRUITING
Conditions: Coronary Artery Disease, Acute Coronary Syndrome
Interventions: DRUG: Standard DAPT|DRUG: Very-short DAPT less than 1 month after PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biopharmaceutical Study of Glyco pMDI With or Without Charcoal Block vs IV Bolus in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Glycopyrrolate|DRUG: Glycopyrrolate|DRUG: Glycopyrrolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liberal Oxygenation Versus Conservative Oxygenation in ARDS
Status: UNKNOWN
Conditions: Acute Respiratory Distress Syndrome|Intensive Care
Interventions: DRUG: Modulation of Inspired Fraction of Oxygen (FiO2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Full Thickness Macular Hole; Should it be Handled Subacutely?
Status: RECRUITING
Conditions: Full Thickness Macular Hole
Interventions: PROCEDURE: Vitrectomy (Sequential phakoemulsification and vitrectomy)|PROCEDURE: Combined phako-vitrectomy|PROCEDURE: Phako (Sequential phakoemulsification and vitrectomy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The MEseNchymal coviD-19 Trial: MSCs in Adults With Respiratory Failure Due to COVID-19 or Another Underlying Cause
Status: COMPLETED
Conditions: Covid19|Acute Respiratory Distress Syndrome
Interventions: BIOLOGICAL: CYP-001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Association Between Apical Dysfunction and Trans Apical Access for TAVR, in Patients With Severe Aortic Stenosis, Undergoing Trans Apical Trans Catheter Aortic Valve Replacement (TAP-TAVR).
Status: UNKNOWN
Conditions: Severe Symptomatic Aortic Stenosis
Interventions: DEVICE: MRI test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Thromboelastometry-guided Treatment Protocol Versus Standard Care of Major Haemorrhage in Obstetric Patients
Status: COMPLETED
Conditions: Obstetric Labor Complications|Hemorrhage
Interventions: DEVICE: Rotational Thromboelastometry (ROTEM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Chronic Application of Tear Formulations
Status: UNKNOWN
Conditions: Dry Eye
Interventions: DRUG: Next Generation Emulsion|DRUG: Refresh Dry Eye Therapy|DRUG: Refresh Contacts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Y-90 Versus SBRT for Inoperable HCC
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma|Stage I Hepatocellular Carcinoma AJCC v8|Stage IA Hepatocellular Carcinoma AJCC v8|Stage IB Hepatocellular Carcinoma AJCC v8|Stage II Hepatocellular Carcinoma AJCC v8|Stage III Hepatocellular Carcinoma AJCC v8|Stage IIIA Hepatocellular Carcinoma AJCC v8|Stage IIIB Hepatocellular Carcinoma AJCC v8|Stage IVA Hepatocellular Carcinoma AJCC v8
Interventions: OTHER: Quality of Life|OTHER: Questionnaire Administration|RADIATION: Stereotactic Body Radiation Therapy|PROCEDURE: Yttrium-90 Microsphere Radioembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Evaluation of a Sensory-tonic Stimulation on Development of Parent-infant Interactions and Social Cognition in Very Premature Children
Status: RECRUITING
Conditions: Very Preterm Birth
Interventions: BEHAVIORAL: sensory-tonic stimulation|BEHAVIORAL: skin-to-skin contact
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HSK7653 Treatment in Patients With Type 2 Diabetes Who Are Not Controlled With Diet and Exercise
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: HSK7653 10 mg Q2W|DRUG: HSK7653 25 mg Q2W|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Label Compliance for Attention Deficit/Hyperactivity Disorder (ADHD) Medications in Japan
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: MPH (Concerta)|DRUG: MPH (Ritalin)|DRUG: Atomoxetine (ATO)|DRUG: Guanfacine (GFC)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PancFit: Multimodal Exercise During Preoperative Therapy for Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Other Disorders of Glucose Regulation and Pancreatic Internal Secretion|Pancreatic Cancer
Interventions: BEHAVIORAL: Questionnaires|BEHAVIORAL: Nutritional Questionnaire and Nutritional Counseling|OTHER: Booklet|BEHAVIORAL: Aerobic Exercise and Strength Training Exercises|BEHAVIORAL: Phone Calls|BEHAVIORAL: Physical Assessments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Randomized, Double-Blind, Controlled Study of the Use of Anti-HIV Immune Serum Globulin (HIVIG) for the Prevention of Maternal-Fetal HIV Transmission in Pregnant Women and Newborns Receiving Zidovudine (AZT)
Status: COMPLETED
Conditions: HIV Infections|Pregnancy
Interventions: DRUG: Anti-HIV Immune Serum Globulin (Human)|DRUG: Globulin, Immune|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Fixed Dose Combination GSP 301 Nasal Spray (NS) in the Treatment of Seasonal Allergic Rhinitis (SAR)
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: GSP 301 NS|DRUG: Olopatadine HCl NS|DRUG: Mometasone furoate NS|DRUG: GSP 301 Placebo NS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have an Inadequate Response to MTX (SELECT-MONOTHERAPY)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Methotrexate|DRUG: Upadacitinib|DRUG: Placebo Upadacitinib|DRUG: Placebo Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: One Year Study to Evaluate the Safety of the Combination of Valsartan and Amlodipine in Patients With Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: valsartan+amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MR-based Hypofractionated Adaptive IGRT of Prostate Cancer (M-base HyPro 2.0)
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: RADIATION: Plan adaptation of Radiation Treatment in case of anatomical changes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Portable Hydrogen Rich Water Machine is Used for Adjuvant Treatment of Patients With Hyperlipidemia
Status: RECRUITING
Conditions: Hyperlipidemias
Interventions: DEVICE: General dietary guidance and hydrogen water prepared by portable hydrogen rich water machine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the RelAte Mealtime Program as an Intervention to Treat Social Isolation and Improve Cooking Behaviour Among Older Adults Living Alone
Status: COMPLETED
Conditions: Social Isolation|Meals
Interventions: BEHAVIORAL: Mealtime Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Immunogenicity and Safety of Menactra® Vaccine in Adolescents in Saudi Arabia
Status: COMPLETED
Conditions: Neisseria Meningitidis|Meningococcal Infections
Interventions: BIOLOGICAL: Menactra®: Meningococcal A, C, Y, and W 135 Polysaccharide Diphtheria Toxoid Conjugate vaccine|BIOLOGICAL: Mencevax®: Group A, C, W135 and Y polysaccharide meningococcal vaccine|BIOLOGICAL: Menactra®: Meningococcal A, C, Y, and W 135 Polysaccharide Diphtheria Toxoid Conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acute Myeloid Leukemia and Markers of Leukemia Stem Cells (CLL1 and CD45RA)
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DIAGNOSTIC_TEST: Quantification of blood cells positive for CLL1 and CD45RA surface markers by flow cytometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fasting Study of Metolazone Tablets 2.5 mg and Zaroloxyn® Tablets 2.5 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Metolazone Tablets 2.5 mg|DRUG: Zaroloxyn® Tablets 2.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase 3 Study of Reltecimod vs Placebo in Patients With Sepsis-associated Acute Kidney Injury
Status: TERMINATED
Conditions: Acute Kidney Injury|Peritonitis|Necrotizing Soft Tissue Infection
Interventions: DRUG: Reltecimod 0.5 mg/kg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Efficacy and Safety of Dupilumab in Pediatric Patients With Active Eosinophilic Esophagitis (EoE)
Status: COMPLETED
Conditions: Eosinophilic Esophagitis (EoE)
Interventions: DRUG: Dupilumab|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Urokinase-type Plasminogen Activator Receptor and Gastroesophageal Cancer
Status: COMPLETED
Conditions: Esophagus Cancer, Adenocarcinoma
Interventions: OTHER: uPAR immunohistochemistry
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Folic Acid on Primary Folate Forms in Relation to MTHFR
Status: COMPLETED
Conditions: the Effect of MTHFR C677T on Folate Metabolism
Interventions: DIETARY_SUPPLEMENT: folic acid plus B6 and B12|DIETARY_SUPPLEMENT: folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial"
Status: UNKNOWN
Conditions: Colitis, Ulcerative|Crohn's Disease
Interventions: DRUG: Infliximab-Biosimilar|DRUG: Infliximab-Innovator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Oophorectomy and Tamoxifen in Premenopausal Women With Hormone Receptor-Positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Tamoxifen|PROCEDURE: Surgery: Oophorectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrotherapy in the Management of Myofascial Syndrome
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DEVICE: TENS (transcutaneous electrical nerve stimulation)|DEVICE: TENS (transcutaneous electrical nerve stimulation) ECOMODYN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mechanisms of Manual Therapies in CAI Patients
Status: COMPLETED
Conditions: Ankle Inversion Sprain|Chronic Instability of Joint
Interventions: OTHER: Joint Mobilization|OTHER: Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Vitamin D Supplementation on Blood Pressure and HbA1c Levels in Patients With T2D
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: 25(OH) vitamin D|DRUG: 0.9 % NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Additives to Epidural Bupivacaine in Normal Labor
Status: NOT_YET_RECRUITING
Conditions: Labor Pain
Interventions: DRUG: Dexmedetomidine|DRUG: fentanyl|DRUG: Nalbuphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment Safety and Efficacy of Pro-ocular™ 1% for Chronic Ocular Graft Following Allogeneic HSCT.
Status: COMPLETED
Conditions: Chronic Ocular Graft-versus-host Disease
Interventions: DRUG: Pro-ocular™ topical gel|DRUG: Placebo topical gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Corticosteroid Meniscectomy Randomized Trial
Status: ENROLLING_BY_INVITATION
Conditions: Osteoarthritis, Knee|Meniscus Tear|Meniscus; Degeneration|Synovitis
Interventions: DRUG: Zilretta Injectable Product or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Renal Transplantation and Inhaled Anesthetic Sevoflurane (SEVOREIN)
Status: COMPLETED
Conditions: End-stage Chronic Renal Disease|Severe Acute Kidney Failure|Renal Transplantation
Interventions: DRUG: Sevoflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Traditional Chinese Cervical Manipulation for Cervicogenic Headache
Status: NOT_YET_RECRUITING
Conditions: Cervicogenic Headache
Interventions: OTHER: Traditional Chinese cervical manipulation|OTHER: Sham manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Telenutrition for the Treatment of Overweight Patients With Obesity and/or High Cardiometabolic Risk
Status: RECRUITING
Conditions: Overweight and Obesity
Interventions: BEHAVIORAL: OBE-COACH program|DEVICE: Connected devices|DEVICE: Connected Activity Tracer|BEHAVIORAL: e-learning program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: AMR PH GL 2007 CL001 Phase 3 Trial in Patients With Small Cell Lung Cancer After Failure of First-Line Chemotherapy
Status: COMPLETED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Amrubicin|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: fixAtion of skiN Flaps After Mastectomy Using ruNning or Interrupted suturEs for Combatting Seroma
Status: NOT_YET_RECRUITING
Conditions: Seroma
Interventions: PROCEDURE: flap fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cardiovascular Disease Screening
Status: TERMINATED
Conditions: Congenital Heart Disease|Atherosclerosis|Myocardial Ischemia|Myocardial Infarction|Acquired Heart Disease
Interventions: DEVICE: Toshiba Aquilion ONE CT|DEVICE: SWiemens MRI scanner
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Antiviral Responses to NNRTI-Based vs. PI-Based ARV Therapy in HIV Infected Infants Who Have or Have Not Received Single Dose NVP for Prevention of Mother-to-Child Transmission of HIV
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Lamivudine|DRUG: Lopinavir/ritonavir|DRUG: Nevirapine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Spinal Anesthesia Versus General Anesthesia in Sepsis
Status: RECRUITING
Conditions: Sepsis|Continuous Spinal Anesthesia|General Anesthesia
Interventions: DRUG: Continuous spinal anesthesia|DRUG: General anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT