pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Using Combined EEG and Non-invasive Brain Stimulation to Examine and Improve Reward Functioning in Opioid Use Disorder
Status: COMPLETED
Conditions: Opioid-use Disorder
Interventions: DEVICE: Active repetitive transcranial magnetic stimulation (rTMS)|DEVICE: Sham repetitive transcranial magnetic stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Microbiome Analysis in esoPhageal, PancreatIc and Colorectal CaNcer Patients Undergoing Gastrointestinal Surgery
Status: UNKNOWN
Conditions: Gastrointestinal Cancer|Colorectal Cancer|Pancreatic Cancer|Esophageal Cancer|Rectum Neoplasm|Esophageal Neoplasms|Pancreatic Ductal Adenocarcinoma|Colonic Neoplasms|Gastrointestinal Microbiome|Microbiota|Anastomotic Leak
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A STUDY TO LEARN HOW THE STUDY MEDICINE CALLED PF-07293893 AFFECTS MUSCLE BIOMARKERS OF HEALTHY ADULTS
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: PF-07293893|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms
Status: COMPLETED
Conditions: Aneurysms|Arteriovenous Malformations
Interventions: DRUG: minocycline|DRUG: doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: YoUng Adolescents' behaViour, musculoskeletAl heAlth, Growth & Nutrition
Status: ENROLLING_BY_INVITATION
Conditions: Arrest of Bone Development or Growth|Constitutional Delay of Growth and Puberty|Malnutrition, Child|Gestational Diabetes|Muscle Tone Abnormalities|Anemia
Interventions: BEHAVIORAL: Knowledge, Attitude & Practices
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Study of Dermal-Living Skin Replacement to Treat Diabetic Foot Ulcers
Status: TERMINATED
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: Dermal - Living Skin Replacement (Dermal-LSR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Mometasone Nasal Irrigation for Chronic Rhinosinusitis
Status: COMPLETED
Conditions: Chronic Rhinosinusitis (Diagnosis)|Allergic Rhinosinusitis|Chronic Eosinophilic Rhinosinusitis
Interventions: DRUG: Mometasone Furoate Nasal Irrigation|DRUG: Mometasone Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics Capsule as Supplemental Therapy for Group B Streptococci Infection and Vaginitis During Pregnancy
Status: UNKNOWN
Conditions: Pregnancy
Interventions: DIETARY_SUPPLEMENT: lactic acid bacteria|DIETARY_SUPPLEMENT: cranberry|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TAU-2014-1: Mibefradil and Hypofractionated Re-Irradiation Therapy in Recurrent GBM
Status: COMPLETED
Conditions: Glioblastoma Multiforme (GBM)
Interventions: DRUG: Mibefradil with Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selinexor, Pomalidomide, and Dexamethasone For Multiple Myeloma With CNS Involvement
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: SPD：Selinexor Oral Tablet, Pomalidomide, Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic "DA VINCI" Robot Assisted Abdominal Wall Hernia Repair
Status: COMPLETED
Conditions: Abdominal Wall Hernia
Interventions: DEVICE: Laparoscopic DA VINCI Robot Assisted coelioscopy|PROCEDURE: conventional coelioscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Lucentis (Ranibizumab) and Visudyne (Verteporfin) Combination Therapy in Neovascular AMD
Status: COMPLETED
Conditions: Neovascular Age Related Macular Degeneration
Interventions: DRUG: Ranibizumab; Verteporfin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Intranasal Kovacaine Mist, Tetracaine Alone, and Placebo for Anesthetizing Maxillary Teeth
Status: TERMINATED
Conditions: Anesthesia
Interventions: DRUG: Tetracaine HCl 3% and oxymetazoline HCl 0.05%|DRUG: Tetracaine HCl 3%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of CD137 Agonist ADG106 With Advanced or Metastatic Solid Tumors and/or Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Solid Tumors, Non-Hodgkin Lymphoma
Interventions: DRUG: ADG106
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder
Status: TERMINATED
Conditions: Bipolar Disorder|Anxiety Disorders|Bipolar Affective Disorder|Bipolar Depression
Interventions: DRUG: Riluzole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 1-Year Safety Study of OTO-104 in Subjects With Unilateral Meniere's Disease Located in United Kingdom
Status: COMPLETED
Conditions: Meniere's Disease
Interventions: DRUG: OTO-104|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence (BE) Study Comparing The Commericializable And Clinical Formulations Of PF-00299804
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Treatment A-B|DRUG: Treatment B-A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Neural Mechanisms of Cognitive Assessment and Rehabilitation for Cognitive Decline
Status: RECRUITING
Conditions: Mild Cognitive Impairment (MCI)|Subjective Cognitive Decline (SCD)|Aging|Healthy
Interventions: COMBINATION_PRODUCT: multi-modal targeted intervention (e.g., cognitive training, exercise, games)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Clinical Outcomes of Cryobiopsy for Peripheral Pulmonary Lesions - A Prospective Pilot Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Nodule
Interventions: DIAGNOSTIC_TEST: Transbronchial cryobiopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Image-Guided Stereotactic Radiosurgery (SRS) Boost for HPV-Oropharyngeal Cancer
Status: COMPLETED
Conditions: Cancer of the Oropharynx
Interventions: RADIATION: Stereotactic Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Mindfulness-based Stress Reduction Programme Given to Infertile Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Depression Anxiety Disorder|Demography, Family|Awakening Early
Interventions: OTHER: mindfulness-based stress reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Clinical Efficacy Analysis of Resveratrol in the Treatment of Primary Ovarian Insufficiency
Status: UNKNOWN
Conditions: Primary Ovarian Insufficiency
Interventions: DRUG: Resveratrol|DRUG: Vitamin E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Electronically Derived Automated Reports of Appropriate Antibiotic Use to Inform Stewardship Interventions
Status: RECRUITING
Conditions: Community-acquired Pneumonia|Acute Otitis Media|Pharyngitis
Interventions: BEHAVIORAL: Mixed methods intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Different Intra-articular Injections Primary Gonarthrosis
Status: COMPLETED
Conditions: Gonarthrosis; Primary
Interventions: DRUG: Tenoxicam 20 Mg Powder for Solution for Injection Vial|DRUG: Methylprednisolone|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Biomarkers of Androgen Response and Resistance In Evolution During a Rising PSA
Status: COMPLETED
Conditions: Castration-resistant Prostate Cancer
Interventions: DRUG: Abiraterone + prednisone|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of M200(Volociximab in Combination With Liposomal Doxorubicin)
Status: COMPLETED
Conditions: Ovarian Cancer, Primary Peritoneal Cancer
Interventions: DRUG: M200 (Volociximab)|DRUG: Liposomal Doxorubicin|DRUG: M200 (Volociximab)|DRUG: M200 (Volociximab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET/CT Imaging in COVID-19 Patients
Status: ENROLLING_BY_INVITATION
Conditions: COVID-19|SARS-CoV-2 Infection
Interventions: DRUG: 18F-αvβ6-BP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: ActiV.A.C.+ Compression Therapy Versus Compression Therapy Alone for the Treatment of Chronic Venous Ulcerations
Status: TERMINATED
Conditions: Chronic Venous Hypertension With Ulcer
Interventions: DEVICE: ActiVAC System|OTHER: Compression therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concomitant Limb Cryocompression and Scalp Cooling to Reduce Paclitaxel-induced Neuropathy and Alopecia
Status: UNKNOWN
Conditions: Chemotherapy-induced Peripheral Neuropathy (CIPN)
Interventions: DEVICE: Concomitant limb cryocompression and scalp cooling|DEVICE: Concomitant limb cryocompression and scalp cooling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: 11C-ER176|DRUG: 18F-MK6240|DRUG: 18F-Florbetaben|PROCEDURE: Lumbar Puncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Polysomnographic Study Comparing the Use of Dexmedetomidine and Zolpidem to Induce Natural Sleep
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: Dexmedetomidine|DRUG: Zolpidem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Static and Dynamic Opening With Neural Sliding in Cervical Radiculopathy
Status: RECRUITING
Conditions: Cervical|Cervical Radiculopathy
Interventions: OTHER: static opening with slider+ Conventional PT|OTHER: dynamic opener with slider + Conventional PT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of CJ-30060 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy Male Subjects
Interventions: DRUG: Exforge® tab 10/160mg, Crestor® tab 20mg|DRUG: CJ-30060 10/160/20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Understanding the Health Effect of a Bioactive Peptide From Egg: A Pilot Study
Status: NOT_YET_RECRUITING
Conditions: High Blood Sugar|High Blood Pressure|Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: Egg White Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Asthma in the Elderly: A Study of Choline Supplementation
Status: COMPLETED
Conditions: Asthma in the Elderly
Interventions: DIETARY_SUPPLEMENT: Choline|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SGLT2 Inhibitor Therapy in Cystic Fibrosis-related Diabetes
Status: RECRUITING
Conditions: Cystic Fibrosis-related Diabetes|Cystic Fibrosis
Interventions: DRUG: Empagliflozin|OTHER: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Conservative vs an Ablative Approach for Treatment of Hyperthyroidism in Patients With Graves' Orbitopathy
Status: RECRUITING
Conditions: Graves' Orbitopathy
Interventions: DRUG: Methimazole|PROCEDURE: Radioiodine or thyroidectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin to Treat Corticosteroids-induced Hyperglycemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Pregnancy Preterm|Glycemic Control|Corticosteroids Induced Hyperglycemia
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: iStent Inject in OAG Subjects on 2 Pre-op Topical Ocular Hypotensive Medications
Status: TERMINATED
Conditions: Primary Open Angle Glaucoma (POAG)
Interventions: DEVICE: iStent inject surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Doses of Anti-NOGO A in Relapsing Forms of Multiple Sclerosis
Status: TERMINATED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: GSK1223249|OTHER: Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tolerability and Safety of a New Cumulative Dose of Grass MATA MPL
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: BIOLOGICAL: Placebo comparator|BIOLOGICAL: Grass MATA MPL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Behavioral Effects of Drugs (Inpatient): 40 [Methamphetamine, Methylphenidate, Duloxetine]
Status: COMPLETED
Conditions: Methamphetamine Use Disorder
Interventions: DRUG: Methamphetamine|DRUG: Methylphenidate|DRUG: Placebo oral capsule|DRUG: Duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Roll-over Study to Continue Treatment With the Investigational Drug Rogaratinib and to Further Test Its Safety
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Rogaratinib (BAY1163877)|DRUG: Combination drug
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pioglitazone on Macrovascular Outcome in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Castration Compared to Castration Plus Metformin as First Line Treatment for Patients With Advanced Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Placebo|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bupivacaine Digital Blocks: How Long is the Pain Relief and Temperature Elevation?
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Bupivacaine 0.5%|DRUG: Bupivacaine 0.5% + Epinephrine (1:200,000)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Genotype-Guided Warfarin Therapy Trial
Status: COMPLETED
Conditions: Atrial Fibrillation|Deep Vein Thrombosis|Pulmonary Embolism|Artificial Heart Valve
Interventions: OTHER: Genotype-guided dose determination|OTHER: Non-genotype guided warfarin dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Redesign, Implementation and Evaluation of the Effectiveness of the Aktio Myoelectric Prosthesis
Status: ACTIVE_NOT_RECRUITING
Conditions: Upper Limb Amputation Below Elbow (Injury)|Prosthesis User|Satisfaction, Patient
Interventions: DEVICE: Aktio prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hypoglycemia and Autonomic Nervous System Function
Status: COMPLETED
Conditions: Hypoglycemia
Interventions: OTHER: Hypoglycemic hyperinsulinemic clamp|OTHER: Euglycemic hyperinsulinemic clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Allogeneic Left Atrial and Pulmonary Vein Transplant for Pulmonary Vein Stenosis
Status: SUSPENDED
Conditions: Pulmonary Vein Stenosis
Interventions: PROCEDURE: LA transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Monitoring of Chronic Heart Failure in Veneto Region
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: PROCEDURE: Telemonitoring for patients with Congestive Heart Failure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Weight Management Plus LNG-IUS/Megestrol Acetate in Endometrial Atypical Hyperplasia
Status: RECRUITING
Conditions: Atypical Endometrial Hyperplasia|Fertility Issues|Overweight and Obesity
Interventions: BEHAVIORAL: Intensive Lifestyle Intervention (ILI)|DRUG: Megestrol Acetate 160 MG Oral Tablet|DRUG: Levonorgestrel-Releasing Intrauterine Contraceptive System (Mirena), 52 Mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Endovenous Microwave Ablations for Treatment of Varicose Veins in Singapore
Status: UNKNOWN
Conditions: Venous Insufficiency|Varicose Veins|Vascular Diseases
Interventions: OTHER: Questionnaires|OTHER: Physical examinations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RATTRAP: Infliximab Versus Rituximab in Systemic Necrotizing Vasculitides
Status: COMPLETED
Conditions: Wegener's Granulomatosis|Churg-Strauss Syndrome|Microscopic Polyangiitis
Interventions: DRUG: Infliximab|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spatial Analysis of Host-parasite Interactions in Cutaneous Leishmaniasis in Ethiopia
Status: ACTIVE_NOT_RECRUITING
Conditions: Cutaneous Leishmaniases
Interventions: DIAGNOSTIC_TEST: skin biopsy|DIAGNOSTIC_TEST: venous blood sample (plasma, PBMC, WB)|GENETIC: venous blood sample (HLA)|GENETIC: skin slit
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess The Effects Of Effexor XR On Cardiac Repolarization In Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Venlafaxine|DRUG: Moxifloxacin|DRUG: Drug - placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Preoperative Oral Hydration in the Ambulatory Arthroplasty Population
Status: RECRUITING
Conditions: Same-day Discharge|Length of Stay
Interventions: DIETARY_SUPPLEMENT: Complex Carbohydrate Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prolonged Treatment for Infected Abortion After Hospital Discharge.
Status: TERMINATED
Conditions: Septic Abortion
Interventions: DRUG: metronidazole and doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extension to a Study of the Efficacy and Safety of Vildagliptin in Patients With Type 2 Diabetes With Hemoglobin A1c (HbA1c) 9-11%
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Culprit Lesions in NSTEMI With Multi Vessel Disease (NSTEMI-CULPRIT)
Status: RECRUITING
Conditions: NSTEMI - Non-ST Segment Elevation MI|Multi Vessel Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: CMR and OCT in NSTEMI patients with MVD
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PD, PK, and Safety of ALTO-203 in Patients With MDD
Status: RECRUITING
Conditions: Major Depressive Disorder|Anhedonia
Interventions: DRUG: ALTO-203 25 μg|DRUG: ALTO-203 75 μg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immuno & Reacto of TF Trivalent Influenza Split Vaccine 2003/04 or of Std Formulation Influsplit SSW®/Fluarix™ 2003/04
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Thiomersal free trivalent influenza split vaccine 2003/2004|BIOLOGICAL: GlaxoSmithKline Biologicals' Influsplit SSW®/Fluarix™ 2003/2004
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Roxadustat Combined With Sacubitril Valsartan Sodium Tablets in the Treatment of Cardiorenal Anemia Syndrome
Status: UNKNOWN
Conditions: Cardio-Renal Syndrome
Interventions: DRUG: Roxadustat;Sacubitril Valsartan Sodium Tablets;|DRUG: EPO; ACEI / ARB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recovery From dNMB Using Different Sugammadex Doses in Elderly Patients Undergoing Robot-assisted Prostatectomy
Status: COMPLETED
Conditions: Prostate Cancer|Neuromuscular Blockade
Interventions: DRUG: Sugammadex 6 mg/kg|DRUG: Sugammadex 4 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of NGX267 Oral Capsules in Patients With Xerostomia Associated With Sjorgren's Syndrome
Status: COMPLETED
Conditions: Xerostomia|Sjogren's Syndrome
Interventions: DRUG: NGX267|DRUG: NGX267|DRUG: NGX267|DRUG: NGX267
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Schroth Exercises Combined With Laser Acupuncture Therapy in Adolescent Idiopathic Scoliosis
Status: COMPLETED
Conditions: Adolescent Idiopathic Scoliosis|Laser Acupuncture
Interventions: BEHAVIORAL: Schroth exercise therapy|DEVICE: laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Three Fluoroquinolone Topical Eyedrops in the Treatment of Infectious Corneal Ulcers.
Status: TERMINATED
Conditions: Corneal Ulcers
Interventions: DRUG: Besivance 0.6% Ophthalmic Suspension|DRUG: Zymaxid 0.5% Ophthalmic Solution|DRUG: Vigamox 0.5% Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Epratuzumab Versus Placebo in Subjects With Moderate to Severe General Systemic Lupus Erythematosus (SLE)
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Placebo|DRUG: Epratuzumab|DRUG: Epratuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multifaceted Nutrition Intervention for Frailty in the Community Elderly
Status: RECRUITING
Conditions: Frail|Elderly|Nutrition Disorders in Old Age
Interventions: BEHAVIORAL: multifaceted nutrition intervention|BEHAVIORAL: Nutritional and Exercise Combined Intervention|BEHAVIORAL: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Dual-center Study Evaluating Clinical Acceptance of a NPWT Wound Care System
Status: COMPLETED
Conditions: Diabetic Foot Ulcer|Pressure Injury|Pressure Ulcer|Surgical Wound|Acute Wound|Traumatic Wound|Dehiscence|Edema
Interventions: DEVICE: Invia Motion Endure NPWT system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of Sensitive Skin and Its Biophysical Response in a Latin-American Population
Status: COMPLETED
Conditions: Skin Irritancy Tests
Interventions: PROCEDURE: 10% lactic acid test|PROCEDURE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Validation of PolyDeep: an Artificial Intelligence-based Computer-aided Polyp Detection (CADe) and Characterization (CADx) System. Polydeep Advance 2.
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DIAGNOSTIC_TEST: Standard technique First colonoscopy without PolyDeep|DIAGNOSTIC_TEST: Combination technique First colonoscopy with PolyDeep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Gut Microbiota Analysis in IAI Patients With Sepsis-associated Liver Dysfunction
Status: COMPLETED
Conditions: Gut Microbiota|Intra-abdominal Infections|Acute Gastrointestinal Injury|Sepsis-associated Liver Dysfunction
Interventions: BEHAVIORAL: Gut microbiota Analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Accuracy in the Evaluation of Brain Response to Mechanical and Radiofrequency Stimuli in Humans
Status: COMPLETED
Conditions: Brain Response Evoked by Radiofrequency Stimuli in Humans|Brain Response Evoked by Pinprick Stimuli in Humans
Interventions: OTHER: Radiofrequency application|OTHER: Pinprick stimuli
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Pioglitazone on Ambulatory Blood Pressure
Status: COMPLETED
Conditions: Hypertension|Diabetes Mellitus Type 2
Interventions: DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety, Tolerability and Efficacy in Male and Female With AGA Treated With HMI-115 Over a 24-week Treatment Period
Status: COMPLETED
Conditions: Androgenetic Alopecia
Interventions: DRUG: HMI-115
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smoking Cessation Behavioral Treatment Study
Status: RECRUITING
Conditions: Tobacco Use Disorder
Interventions: BEHAVIORAL: Mindfulness-Oriented Recovery Enhancement (MORE)|BEHAVIORAL: Cognitive Behavioral Therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intervention for Comorbid Substance Use and Bipolar Disorders
Status: ENROLLING_BY_INVITATION
Conditions: Bipolar Disorder|Substance Use Disorders
Interventions: BEHAVIORAL: Integrated Treatment Adherence Program (ITAP)|BEHAVIORAL: Safety Assessment and Follow-up Evaluation (SAFE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Elaboration of a Model for Predicting Efficacy of Monoclonal Antibodies (Cetuximab and Bevacizumab) in Patients With Colorectal Cancer and Liver Metastases
Status: TERMINATED
Conditions: Colorectal Cancer|Neoplasm Metastasis
Interventions: DRUG: cetuximab|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ascertain the Optimal Starting Dose of Mircera Given Subcutaneously for Maintenance Treatment of Anemia in Pediatric Patients With Chronic Kidney Disease on Dialysis or Not Yet on Dialysis.
Status: COMPLETED
Conditions: Anemia|Renal Insufficiency, Chronic
Interventions: DRUG: Mircera
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of HYML-122 and Cytarabine in Patients With FLT3 Positive Relapsed or Refractory Acute Myeloid Leukemia (AML)
Status: RECRUITING
Conditions: Relapsed or Refractory Acute Myeloid Leukemia (AML)
Interventions: DRUG: HYML-122; cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Effective Local Anesthetic Volume for Pain Relief Using Brachial Plexus Block
Status: RECRUITING
Conditions: Post Operative Pain
Interventions: DRUG: Dose of 0.5% Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coronary Sinus Reducer for Treatment of Refractory Angina - COSIRA
Status: COMPLETED
Conditions: Refractory Angina
Interventions: DEVICE: Neovasc Reducer|DEVICE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: pLatelEts And MigRaine iN patEnt foRamen Ovale
Status: COMPLETED
Conditions: Platelet Aggregation, Spontaneous|Migraine With Aura|Patent Foramen Ovale
Interventions: DEVICE: patent foramen ovale closure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effects of Canagliflozin (JNJ-28431754) on the Pharmacokinetics and Safety of an Oral Contraceptive in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oral contraceptive|DRUG: Canagliflozin (JNJ-28431754)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Selective Laser Trabeculoplasty
Status: UNKNOWN
Conditions: Primary Open Angle Glaucoma|Ocular Hypertension|Pseudo-Exfoliative Glaucoma|Pigment Dispersion Glaucoma
Interventions: PROCEDURE: Selective laser trabeculoplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia
Status: COMPLETED
Conditions: Idiopathic Scoliosis|Spondylolisthesis
Interventions: DRUG: Ketamine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Feeding Tube Attachment Device Versus Conventional Fixation and Its Impact on Accidental Exit of Enteral Feeding Tubes
Status: COMPLETED
Conditions: Adult|Enteral Nutrition|Tube Feeding
Interventions: DEVICE: Interventional Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The ABC Trial Does All-Blood Cardioplegia Prevent Blood Transfusion in Cardiac Surgery? A Single Centre Pilot Study
Status: COMPLETED
Conditions: Coronary Artery Disease|Valvular Heart Disease
Interventions: OTHER: All-blood cardioplegia|PROCEDURE: Standard cardioplegia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Acute (2 h) and Short-term (4 Days) Nitrate Supplementation in the Form of Red Beet Root Juice on Intense Intermittent Exercise Performance.
Status: COMPLETED
Conditions: Exercise Performance
Interventions: OTHER: Test Beet Shot|OTHER: Placebo Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Efficacy and Safety of MLTA3698A in Combination With a Disease-Modifying Anti-Rheumatic Drug (DMARD) Compared With Adalimumab in Combination With a DMARD in Patients With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: MLTA3698A|DRUG: adalimumab|DRUG: leflunomide|DRUG: methotrexate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety/Feasibility of Vonapanitase Following Angioplasty for Patients With Peripheral Artery Disease (PAD) Below the Knee (BTK)
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: DRUG: vonapanitase|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Goal2QuitVaping for Nicotine Vaping Cessation Among Adolescents
Status: COMPLETED
Conditions: Depressive Symptoms|Depression|Adolescent Behavior
Interventions: BEHAVIORAL: Behavioral Activation Therapy app|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nitrate Supplementation; Duration
Status: COMPLETED
Conditions: Time-trial Performance|Submaximal Exercise Performance|Nitrite|Nitrate
Interventions: DIETARY_SUPPLEMENT: Sodium Nitrate|DIETARY_SUPPLEMENT: Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Study to Evaluate the Safety and Efficacy of PAC-14028 Cream in Pediatric Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: PAC-14028 Cream 0.1%|DRUG: PAC-14028 Cream 0.3%|DRUG: PAC-14028 Cream 1.0%|DRUG: PAC-14028 Cream Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Haploidentical Hematopoietic Stem Cell Transplantation With Early ATG and Low Dose Post-transplant Cyclophosphamide
Status: RECRUITING
Conditions: Haploidentical Hematopoietic Stem Cell Transplantation
Interventions: DRUG: ATG-LDPTCy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Transcranial Direct Current Stimulation Associated With Cognitive Training in Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: OTHER: tDCS associated with Tcog
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CyclASol® Phase 1 Study
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CyclASol®|DRUG: Placebo (vehicle)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Net Transition Initiative: Efficacy of Two Next-generation Nets for Control of Malaria in Cote d'Ivoire
Status: NOT_YET_RECRUITING
Conditions: Malaria
Interventions: OTHER: Alpha-cypermethrin and PBO LLIN|OTHER: Alpha-cypermethrin and Clorfenapyr LLIN|OTHER: Alpha-cypermethrin only LLIN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Interest of a Bi-truncal Nerve Block (Femoral + Sciatic) Extended, Systematically Associated With General Anesthesia, in the Femoropopliteal Bypass: Study of Post-operative Analgesia and Peripheral Circulation Downstream
Status: COMPLETED
Conditions: Peripheral Arterial Occlusive Disease
Interventions: DRUG: levobupivacaine, clonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of [18F]-FMISO for Non Operated Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma
Interventions: PROCEDURE: 18F]-FMISO PET-CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of CPAP Treatment in Cognition in Adults With DS and OSA
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: CPAP|OTHER: CONSERVATIVE TREATMENT for OSA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glutathione and Fuel Oxidation in Aging
Status: COMPLETED
Conditions: Aging
Interventions: DIETARY_SUPPLEMENT: Glycine, cysteine (as n-acetylcysteine), alanine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Impact of Using Warm Compress Prior to Daily Injections of Copaxone®
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: glatiramer acetate|PROCEDURE: Warm compress prior to injection of glatiramer acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: KM110329 in Adult Patients With Atopic Dermatitis
Status: UNKNOWN
Conditions: Atopic Dermatitis
Interventions: DIETARY_SUPPLEMENT: KM110329|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Dose Response-Control, Crossover Study to Evaluate the Safety and Efficacy of Two Doses of EUR-1008 (APT-1008) in Chronic Pancreatitis (CP) Participants With Exocrine Pancreatic Insufficiency (EPI)
Status: COMPLETED
Conditions: Chronic Pancreatitis|Exocrine Pancreatic Insufficiency
Interventions: DRUG: Placebo|DRUG: EUR-1008 (APT-1008) High Dose|DRUG: EUR-1008 (APT-1008) Low Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Functional Outcomes and the Restoration of Range of Motion After the Arthroscopic Complete Posterior Knee Capsulotomy in Patients With Extension Deficit of the Knee
Status: RECRUITING
Conditions: Knee Disease|Knee Deformity
Interventions: PROCEDURE: Arthroscopic posterior capsulotomy of the knee
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Eosinophilic Chronic Rhinosinusitis Utilizing Betamethasone Dipropionate Nasal Cream
Status: TERMINATED
Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: DRUG: Betamethasone Dipropionate Nasal Cream 0.0644%|DEVICE: Pre-filled syringe and applicator device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety, Tolerability of JPI-547 in Combination With Modified FOLFIRINOX or Gemcitabine-nab-paclitaxel in Patients With Locally Advanced and Metastatic Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: JPI-547|DRUG: modified FOLFIRINOX|DRUG: Gemcitabine-nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of nanOss Bioactive With Autograft and Bone Marrow Aspirate to Autograft in the Posterolateral Spine
Status: COMPLETED
Conditions: Degenerative Disc Disease|Spinal Stenosis|Spondylolisthesis
Interventions: DEVICE: nanOss Bioactive - posterolateral gutter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EHR-Based Medication Complete Communication Strategy to Promote Safe Opioid Use
Status: COMPLETED
Conditions: Opioid Use, Unspecified
Interventions: BEHAVIORAL: EMC2 Strategy|BEHAVIORAL: SMS Text Reminders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Rhythm Control - Catheter Ablation With or Without Anti-arrhythmic Drug Control of Maintaining Sinus Rhythm Versus Rate Control With Medical Therapy and/or Atrio-ventricular Junction Ablation and Pacemaker Treatment for Atrial Fibrillation
Status: COMPLETED
Conditions: Heart Failure|Atrial Fibrillation
Interventions: PROCEDURE: Rhythm control|OTHER: Rate Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Partial Breast Irradiation With Various Concurrent Chemotherapy Regimens
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: Standard Dose Dense Doxorubucin and Cyclophosphamide|OTHER: Standard Doxorubucin and Cyclophosphamide|OTHER: Standard Docetaxel, Carboplatin, and Herceptin|OTHER: Standard Docetaxel, Doxorubucin and Cyclophosphamide|OTHER: Standard Docetaxel and Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rhythmic Auditory Stimulation on Upper-limb Movements in PD Patients
Status: NOT_YET_RECRUITING
Conditions: Acoustic Stimulation|Parkinson Disease|Movement, Abnormal|Bradykinesia|Arm
Interventions: BEHAVIORAL: Upper-limb movement training with the aid of RAS|BEHAVIORAL: Upper-limb movement training without the aid of RAS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transient Lower Esophageal Sphincter Relaxations and High Resolution Manometry
Status: UNKNOWN
Conditions: Healthy Volunteers
Interventions: DEVICE: Esophageal high resolution manometry associated or not with manometry with perfused Dentsleeve probe (as determined by randomization)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: SCH 52365 Phase II Clinical Study: A Study on the Efficacy and Safety of Monotherapy With SCH 52365 in Patients With First Relapsed Anaplastic Astrocytoma (Study P03745)
Status: COMPLETED
Conditions: Astrocytoma
Interventions: DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimal Invasive Anterior Approach Versus Trans-gluteal Approach for Hemi-arthroplasty in Femoral Neck Fractures
Status: COMPLETED
Conditions: Femoral Neck Fracture
Interventions: PROCEDURE: Trans-gluteal approach, CLAS|PROCEDURE: Anterior minimal invasive approach, AMIS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Sitagliptin and Glibenclamide on the Glucose Variability in Japanese Participants With Type 2 Diabetes Mellitus (MK-0431-355)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin|DRUG: Glibenclamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Preventive Effects of Neurodynamic Mobilisation
Status: COMPLETED
Conditions: Delayed Onset Muscle Soreness
Interventions: OTHER: Femoral nerve neurodynamic mobilization|OTHER: Femoral nerve placebo neurodynamic mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION