pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Rate Control Self-adjustment in Patients With Permanent or Persistent Atrial Fibrillation Using Device Home Monitoring
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation, Persistent
Interventions: COMBINATION_PRODUCT: Self-adjustment of medication
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Studying Changes in Breast Density in Patients With Early-Stage Breast Cancer Treated With Metformin Hydrochloride or Placebo on CAN-NCIC-MA.32
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: metformin hydrochloride|OTHER: clinical observation|OTHER: diagnostic laboratory biomarker analysis|OTHER: imaging biomarker analysis|OTHER: medical chart review|PROCEDURE: digital mammography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Starting Methotrexate Early in Chikungunya Arthritis
Status: COMPLETED
Conditions: Early Chikungunya Arthritis
Interventions: DRUG: Methotrexate|DRUG: NSAID|DRUG: Steroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Leuprolide and Testosterone for Men With Kennedy's Disease or Other Motor Neuron Disease
Status: COMPLETED
Conditions: Spinal Muscular Atrophy|Amyotrophic Lateral Sclerosis|Spinobulbar Muscular Atrophy
Interventions: DRUG: leuprolide|DRUG: testosterone
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Apnea, Bariatric Surgery Versus Continuous Positive Airway Pressure (CPAP) Trial
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Obesity
Interventions: PROCEDURE: Laparoscopic Gastric Banding|PROCEDURE: Continuous Positive Airway Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Collect Samples for MIST Analysis of Zibotentan and Bioavailability of Zibotentan and Dapagliflozin in Heatlhy Participants
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Zibotentan (Treatment A)|DRUG: Dapagliflozin (Treatment A)|DRUG: Zibotentan/Dapagliflozin - Formulation 1 (Treatment B)|DRUG: Zibotentan/Dapagliflozin - Formulation 2 (Treatment C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Innovative Biofeedback Interface for Enhancing Stroke Gait Rehabilitation
Status: RECRUITING
Conditions: Gait, Hemiplegic|Stroke
Interventions: OTHER: AGRF Biofeedback Game|OTHER: Traditional Biofeedback Interface|OTHER: Control Condition|OTHER: Optional Game with VR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Immunogenicity, Safety, Reactogenicity and Persistence of an Investigational Respiratory Syncytial Virus (RSV) Vaccine in Adults Aged 60 Years and Above
Status: ACTIVE_NOT_RECRUITING
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: RSVPreF3 OA investigational vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Development of Immune Globulin Treatment for Avian Flu
Status: TERMINATED
Conditions: Infectious Diseases|Influenza|Avian Flu
Interventions: BIOLOGICAL: H5N1 vaccine|PROCEDURE: Apheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Fluvestrant Combined With Oral Vinorelbine in Hormone Receptor-positive Advanced Breast Cancer
Status: UNKNOWN
Conditions: Hormone Receptor Positive Advanced Breast Cancer
Interventions: DRUG: fluvestrant + oral vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation Of Absorption And Pharmacokinetics Of A Single Dose Of Controlled Release Pregabalin Tablet Administered Fasted In The Evening or Immediately Following A 600-750 Calorie Evening Meal As Compared To Single Dose Of Immediate Release Pregabalin Capsule In Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pregabalin controlled release, 330 mg, 600- 750 calorie|DRUG: Pregabalin controlled release, 330 mg, fasted|DRUG: Pregabalin immediate release, 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Introduction of mTor Inhibitors and the Activation of the Cytomegalovirus (CMV) -Specific Cellular Immune Response
Status: WITHDRAWN
Conditions: Kidney Transplantation|Cytomegalovirus Infections
Interventions: DRUG: Switch from Mycophenolate Mofetil to Everolimus manteinance treatment in Active Comparator Arm|OTHER: no intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Human Leishmaniasis: Antigen Recognition Pattern and Study of New Potential Biomarkers
Status: RECRUITING
Conditions: Leishmaniasis
Interventions: DIAGNOSTIC_TEST: In-house Western blot, specific for Leishmania
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cardiovascular Effects of Very Low Nicotine Content Cigarettes
Status: RECRUITING
Conditions: Tobacco Use
Interventions: DRUG: SPECTRUM cigarettes|OTHER: usual brand of Cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: COugh Among Hypertensive Patients Treated With Telmisartan, Who Had to Stop previoUs ACE-I Treatment Due to couGH in Poland
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan (Kinzal/Pritor, BAY68-9291)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Blood-borne Assessment of Stromal Activation in Esophageal Adenocarcinoma to Guide Tocilizumab Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophageal Adenocarcinoma|Oesophageal Adenocarcinoma|Resectable Carcinoma
Interventions: DRUG: Tocilizumab 20 Mg/mL Intravenous Solution|DRUG: Paclitaxel|DRUG: Carboplatin|RADIATION: External beam radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Endovascular Repair Versus Surveillance for Women With Small Abdominal Aortic Aneurysm
Status: NOT_YET_RECRUITING
Conditions: Abdominal Aortic Aneurysm
Interventions: DEVICE: EVAR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Anlotinib Plus Penpulimab for the Treatment of Sensitive Relapsed Small-Cell Lung Cancer
Status: UNKNOWN
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Anlotinib Plus Penpulimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Serum Levels and Pharmacokinetics of a New Hepatitis B Immune Globulin Following Liver Transplantation
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Specific intravenous anti-hepatitis B immunoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating Patients With Cystinuria and Efficacy and Safety Exploratory Study in the Youngest Children
Status: NOT_YET_RECRUITING
Conditions: Cystinuria
Interventions: DRUG: ADV7103|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Levothyroxine Sodium Tablets 150 mcg
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: Drug Levothyroxine 150 mcg|DRUG: Drug Eutirox 150 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Lisdexamfetamine Dimesylate (LDX) in Adolescents With Attention-Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: DRUG: LDX 30 mg|DRUG: LDX 50 mg|DRUG: LDX 70 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: South African Paediatric Surgical Outcomes Study 2
Status: RECRUITING
Conditions: Paediatric Surgery|Anaemia|Iron Deficiency Anemia|Iron|Prospective Studies|Interventional Studies
Interventions: DIETARY_SUPPLEMENT: Ferrous gluconate syrup or ferrous fumarate/folic acid tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing Inclusive Support and Intervention for Spanish-speaking Latiné Prostate Cancer Survivors
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer
Interventions: BEHAVIORAL: Expanded Prostate Cancer Index Composite and Decision Regret Scale
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety Study of Live Attenuated Oral Shigella (WRSS1) Vaccine in Bangladeshi Adults and Children
Status: COMPLETED
Conditions: Diarrhea
Interventions: BIOLOGICAL: WRSS1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Breathing Exercise on Chemotherapy-induced Nausea and Vomiting in With Autologous Hematopoietic Stem Cell Transplantation Patients
Status: COMPLETED
Conditions: Chemotherapy-induced Nausea and Vomiting
Interventions: OTHER: Breathing exercise group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Performance Evaluation of the NaviCam SB Capsule Endoscope System for the Diagnosis of Small Bowel Diseases
Status: COMPLETED
Conditions: Small Bowel Disease
Interventions: DEVICE: NaviCam SB|DEVICE: PillCam SB3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: PreOperative Methylprednisolone on Thoracic Endovascular Repair for Reducing Post-implantation Syndrome (POMTEVAR)
Status: NOT_YET_RECRUITING
Conditions: Methylprednisolone|Thoracic Endovascular Repair|Post-implantation Syndrome|Type B Aortic Dissection
Interventions: DRUG: methylprednisolone|DRUG: physiological saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase IIa. Open-label, Multicenter, Dose-escalation Study to Assess the Tolerability and Pharmacokinetics of ZD4054 (Zibotentan) Given Orally Once Daily in Subjects With Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasms|Metastases, Neoplasm
Interventions: DRUG: ZD4054 10 mg|DRUG: ZD4054 15 mg|DRUG: ZD4054 22.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Ofatumumab in Relapsing Multiple Sclerosis (RMS) Patients in China
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsing Multiple Sclerosis
Interventions: BIOLOGICAL: Ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Antitumor Activity of Continuous Intravenous Infusion of MEDI-538 in Adults With B-Cell Chronic Lymphocytic Leukemia (CLL)
Status: WITHDRAWN
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: MEDI-538|DRUG: MEDI-538|DRUG: MEDI-538|DRUG: MEDI-538|DRUG: MEDI-538|DRUG: MEDI-538|DRUG: MEDI-538
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Effect of Food and Acid Reducing Agents on the Absorption of Capivasertib in Healthy Participants
Status: COMPLETED
Conditions: Solid and Hematological Malignancies
Interventions: DRUG: Capivasertib|DRUG: Rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Pharmacokinetics and Safety of Epratuzumab in Japanese Systemic Lupus Erythematosus (SLE)
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: Epratuzumab 400 mg|BIOLOGICAL: Epratuzumab 1200 mg|BIOLOGICAL: Epratuzumab 100 mg|BIOLOGICAL: Epratuzumab 600 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LINX Reflux Management System or Fundoplication Clinical Study in Patients With Hiatal Hernia >3 cm
Status: RECRUITING
Conditions: Hiatal Hernia Large|Gastro Esophageal Reflux|Hiatal Hernia|Hiatal Hernia, Paraesophageal|Reflux, Gastroesophageal|Reflux Acid
Interventions: DEVICE: LINX Reflux Management System|PROCEDURE: Fundoplication
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Validation of an Artificial Intelligence System for Postoperative Management of Cataract Patients
Status: UNKNOWN
Conditions: Cataract|Postoperative Complications|Artificial Intelligence
Interventions: DEVICE: An artificial intelligence system for postoperative management of cataract patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Muscle OXPHOS and Nutrient Homeostasis
Status: COMPLETED
Conditions: Mitochondrial Diseases|Obesity
Interventions: OTHER: Tracer-enhanced oral glucose tolerance test (OGTT*)|OTHER: Muscle MRI|OTHER: Dual energy x-ray absorptiometry (DXA)|OTHER: Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Treatment Investigational New Drug (tIND) Program of Tegaserod in Women With Irritable Bowel Syndrome With Constipation or With Chronic Idiopathic Constipation
Status: NO_LONGER_AVAILABLE
Conditions: Irritable Bowel Syndrome With Constipation|Chronic Idiopathic Constipation
Interventions: DRUG: Tegaserod
Study Type: EXPANDED_ACCESS
Clinical trial: Efficacy and Tolerability of STI571 (Imatinib Mesylate) for the Treatment of Fibrosis in Participants With Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis, Scleroderma
Interventions: DRUG: STI571
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study to Evaluate the Safety, Tolerability, PK and PD of SLN124 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: SLN124|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Enthesitis Assessment Before and After Anti-Tumor Necrosis Factor Treatment in Spondyloarthritis
Status: COMPLETED
Conditions: Spondyloarthritis|Enthesitis|Anti-Tumor Necrosis Factor Drugs
Interventions: DRUG: TNF Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Switching From Oral Dopamine Agonists to Rotigotine
Status: COMPLETED
Conditions: Restless Legs Syndrome|Ekbom Syndrome|Willis-Ekbom Disease
Interventions: DRUG: Rotigotine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of the Sodium-glucose Cotransporter 2 Inhibitors+Sacubitril/Valsartan Therapy in Patients With HFrEF.
Status: RECRUITING
Conditions: Heart Failure|Ventricular Remodeling|Ventricular Dysfunction
Interventions: DRUG: SGLT2 inhibitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nivolumab and Ipilimumab in Classical Kaposi Sarcoma (CKS)
Status: UNKNOWN
Conditions: Classic Kaposi Sarcoma
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Combination of VELCADE, Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone or Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With Newly Diagnosed Non-Germinal Center B-Cell Subtype of Diffuse Large B-Cell Lymphoma
Status: COMPLETED
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: VELCADE|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Prednisone|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic and Pharmacodynamic Study of Metformin and Canagliflozin in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Canagliflozin/Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Volatile Anesthetic Protection Of Renal Transplants: VAPOR-1-trail
Status: COMPLETED
Conditions: Kidney Donation/Transplantation
Interventions: DRUG: procedure:sevoflurane-remifentanil/sufentanil|DRUG: volatile agent only during reperfusion|DRUG: propofol-remifentanil/sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Retrospective Study of Anti-Vascular Endothelial Growth Factor (VEGF) Injections for Retinal Vein Occlusion or Diabetic Macular Edema
Status: COMPLETED
Conditions: Retinal Vein Occlusion|Macular Edema
Interventions: DRUG: Anti-VEGF
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Azilsartan Medoxomil and Chlorthalidone Compared to Olmesartan Medoxomil and Hydrochlorothiazide in Participants With Moderate to Severe Hypertension.
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Azilsartan medoxomil and chlorthalidone|DRUG: Azilsartan medoxomil and chlorthalidone|DRUG: Olmesartan medoxomil and hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1b/2a Study of GSBR-1290 in Adult Overweight or Obese Healthy Subjects and Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Overweight or Obesity|Type2 Diabetes Mellitus
Interventions: DRUG: GSBR-1290|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Supraphysiological Androgen to Enhance Chemotherapy Treatment Activity in Metastatic Castration-Resistant Prostate Cancer, SPECTRA Study
Status: RECRUITING
Conditions: Castration-Resistant Prostate Carcinoma|Metastatic Prostate Adenocarcinoma|Stage IVB Prostate Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Scan|DRUG: Carboplatin|PROCEDURE: Computed Tomography|DRUG: Etoposide|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|DRUG: Testosterone Cypionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adrecizumab (HAM8101) to Improve Prognosis and Outcomes in COVID-19 Trial
Status: TERMINATED
Conditions: COVID-19
Interventions: BIOLOGICAL: Adrecizumab (HAM 8101)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of CG0070 Combined With Nivolumab in Cisplatin Ineligible Patients With MIBC
Status: ACTIVE_NOT_RECRUITING
Conditions: Muscle-Invasive Bladder Carcinoma|Bladder Cancer
Interventions: DRUG: CG0070|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamics Study of Enoxalow Compared to Clexane in Healthy Subjects After Intravenous Administration
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Heparin, Low-Molecular-Weight
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of the Mynx Control Venous Vascular Closure Device 6F-12F vs Manual Compression
Status: COMPLETED
Conditions: Venous Vascular Closure
Interventions: DEVICE: MYNX CONTROL™ Venous Vascular Closure Device 6F-12F
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Ursodesoxycholic Acid in Non-Alcoholic Steatohepatitis
Status: COMPLETED
Conditions: Serum Levels of ALAT Transaminases|Serum Markers for Fibrosis and Hepatic Inflammation
Interventions: DRUG: Ursodesoxycholic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Neuromodulation of Trauma Memories in PTSD & Alcohol Dependence
Status: COMPLETED
Conditions: Alcohol Dependence|PTSD
Interventions: DRUG: Propranolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Persistent Poverty Counties Pregnant Women With Medicaid
Status: ENROLLING_BY_INVITATION
Conditions: Tobacco Cessation|Tobacco Use|Tobacco Smoking|Smoking Cessation Financial Incentives|Socioeconomic Status|Contingency Management|Pregnancy
Interventions: BEHAVIORAL: Standard Care + Financial Incentives|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cvac as Maintenance Treatment Patients With Resected Stage I or Stage II Adenocarcinoma (Cancer) of the Pancreas
Status: WITHDRAWN
Conditions: Pancreatic Carcinoma Stage I|Pancreatic Carcinoma Stage II
Interventions: BIOLOGICAL: CVac
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pazopanib Hydrochloride After Leuprolide Acetate or Goserelin Acetate in Treating Patients With Relapsed Prostate Cancer
Status: COMPLETED
Conditions: Recurrent Prostate Cancer
Interventions: DRUG: pazopanib hydrochloride|DRUG: leuprolide acetate|DRUG: goserelin acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Early vs Late SPN on Long-term Quality of Life in ICU Patients After Gastrointestinal Oncological Surgery
Status: UNKNOWN
Conditions: Nutrition Aspect of Cancer
Interventions: PROCEDURE: Early Supplemental Parenteral Nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Learn How Safe the Study Drug Finerenone is and How Well it Works in Indian People With Long-term Decrease in the Kidneys' Ability to Work Properly (Chronic Kidney Disease) Together With Type 2 Diabetes Mellitus
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Kidney Disease|Type 2 Diabetes Mellitus
Interventions: DRUG: Finerenone (Kerendia, BAY94-8862)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Early Nasal Polyposis With Topical Triamcinolone
Status: TERMINATED
Conditions: Nasal Polyps
Interventions: DRUG: Triamcinolone|DRUG: Saline soaked sponge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Camoteskimab in Participants With Still's Disease
Status: TERMINATED
Conditions: Adult Onset Still's Disease
Interventions: DRUG: Camoteskimab (CERC-007, AVTX-007, AEVI-007)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S-Nitrosylation Therapy of COVID-19
Status: ACTIVE_NOT_RECRUITING
Conditions: SARS-CoV2 Infection|Covid19
Interventions: DRUG: SNO|DRUG: Nitrogen gas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Phase Administration of Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation
Status: WITHDRAWN
Conditions: Asthma
Interventions: BIOLOGICAL: Anakinra|OTHER: Anakinra Matching Placebo|DRUG: Dermatophagoides Farinae
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Coherence Combined With Personal Physical Activity in Patients With Cancer
Status: UNKNOWN
Conditions: Physical Activity|Cancer|Hematologic Diseases
Interventions: PROCEDURE: Cardiac Coherence|PROCEDURE: Adapted Physical Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Routine Nasobiliary Insertion During ERCP in High Risk Patients.
Status: COMPLETED
Conditions: Gallstones Complicated by CBD Stones
Interventions: PROCEDURE: ERCP with NB|PROCEDURE: ERCP alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Treatment Study for Ischemic Optic Neuropathy With Opthalmic Timolol Maleate 0.5%
Status: WITHDRAWN
Conditions: Optic Neuropathy, Ischemic|Anterior Ischemic Optic Neuropathy|Ischemic Optic Neuropathy|Optic Neuropathy, Anterior Ischemic
Interventions: DRUG: Timolol maleate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Digital Platform for Diabetes Care Compared to Usual Care in Patients Diagnosed With Type 2 Diabetes.
Status: COMPLETED
Conditions: Type 2 Diabetes Treated With Insulin
Interventions: OTHER: mHealth|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 4-aminopyridine for Skin Wound Healing
Status: NOT_YET_RECRUITING
Conditions: Wounds|Wound of Skin|Wound Heal|Wounds and Injuries
Interventions: DRUG: 4-Aminopyridine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Adebrelimab Plus Dalpiciclib in Head and Neck Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Adebrelimab and dalpiciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Catheter-Directed Venous Thrombolysis in Acute Iliofemoral Vein Thrombosis
Status: COMPLETED
Conditions: Deep Vein Thrombosis
Interventions: PROCEDURE: catheter-directed venous thrombolysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Game Plan: Efficacy of a Brief, Web-based Intervention on Alcohol Use and Sexually-transmitted Infections
Status: RECRUITING
Conditions: Sexually Transmitted Diseases, Bacterial|Alcohol; Harmful Use
Interventions: BEHAVIORAL: Access to Game Plan app and 24-hour helpline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: VIO Imaging for Skin Tissue Assessment (VISTA)
Status: COMPLETED
Conditions: Skin Condition|Skin Diseases|Skin Lesion|Skin Abnormalities|Skin Cancer
Interventions: DEVICE: VIO Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of GRT6005 in Pain Due to Diabetic Polyneuropathy
Status: COMPLETED
Conditions: Pain|Diabetic Neuropathies
Interventions: DRUG: GRT6005|DRUG: GRT6005|DRUG: GRT6005|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Title: Peri-operative Immuno-Chemotherapy in Operable Oesophageal and Gastric Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric Adenocarcinoma|Oesophageal Adenocarcinoma
Interventions: DRUG: FLOT-A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Oral Dose Study of F901318 in Healthy Subjects
Status: COMPLETED
Conditions: Invasive Aspergillosis
Interventions: DRUG: F901318 Dose level A oral|DRUG: Placebo dose level A oral|DRUG: F901318 Dose level B oral|DRUG: Placebo dose level B oral|DRUG: F901318 Dose level C oral|DRUG: Placebo Dose level C oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Diazoxide Choline Controlled-Release Tablet (DCCR) in Patients With Prader-Willi Syndrome
Status: COMPLETED
Conditions: Prader-Willi Syndrome
Interventions: DRUG: DCCR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study With Lymfactin® in the Treatment of Patients With Secondary Lymphedema
Status: TERMINATED
Conditions: Secondary Lymphedema
Interventions: DRUG: Lymfactin® [1 x 10E10 vp]|DRUG: Lymfactin® [1 x 10E11 vp]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of the Herpes Zoster Subunit Vaccine in Lupus
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: Herpes Zoster Subunit (HZ/su) Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Pembrolizumab in Combination With FLOT About Gastroesophageal Junction Cancer:
Status: NOT_YET_RECRUITING
Conditions: Gastroesophageal Junction Cancer
Interventions: DRUG: Pembrolizumab plus chemotherapy (FLOT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial of Digital CBT to Treat Addiction: Digital RITch®CBT vs. Standard CBT
Status: NOT_YET_RECRUITING
Conditions: Substance Use Disorders|Alcohol Use Disorder|Stimulant-Related Disorder
Interventions: DEVICE: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Two Doses of ABT-874 as Compared to Placebo in Subjects With Multiple Sclerosis (MS)
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: ABT-874/Human monoclonal antibody against IL-12|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Adjuvant Entecavir or Tenofovir for Postoperative HBV-HCC
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Entecavir|DRUG: Tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Treatment Protocol of the NHL-BFM and the NOPHO Study Groups for Mature Aggressive B-cell Lymphoma and Leukemia in Children and Adolescents
Status: RECRUITING
Conditions: Mature B-cell Non-Hodgkin Lymphoma
Interventions: DRUG: Rituximab window|DRUG: Additional doses of Rituximab|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Dexamethasone|DRUG: Doxorubicin hydrochloride|DRUG: Vindesine Sulfate|DRUG: Etoposide|DRUG: Ifosfamide|DRUG: Methotrexate|DRUG: Prednisolone|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Educational Intervention Program to Improve the Oral Health of HIV-Positive Children in Kano, Nigeria.
Status: COMPLETED
Conditions: HIV|Dental Caries|Quality of Life|Oral Disease|Oral Infection|Oral Manifestations
Interventions: OTHER: Oral health education and instructions/training for self-oral care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preventive Effect of a Probiotic Tablet on Oral Health in Preschool Children
Status: COMPLETED
Conditions: Dental Caries
Interventions: DIETARY_SUPPLEMENT: probiotic tablet|DIETARY_SUPPLEMENT: sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Norwegian Stoma Trial
Status: RECRUITING
Conditions: Rectal Cancer|Ileostomy; Complications|Quality of Life|Complication,Postoperative
Interventions: PROCEDURE: Rectal resection with diverting stoma|PROCEDURE: Rectal resection without diverting stoma|PROCEDURE: Rectal resection with permanent colostomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Early Migration of Internal Fixation Implants for Femoral Neck Fractures in Young Adults
Status: NOT_YET_RECRUITING
Conditions: Femoral Neck Fractures|Internal Fixation; Complications|Hip Fractures
Interventions: DEVICE: Dynaloc implant|DEVICE: Cannulated cancellous screws
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Acupuncture Combined With Biofeedback Electrical Stimulation on SUI
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: Biofeedback electrical stimulation|PROCEDURE: Acupuncture|COMBINATION_PRODUCT: Acupuncture combined with biofeedback electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Fitusiran in Severe Hemophilia A and B Patients Previously Receiving Factor or Bypassing Agent Prophylaxis
Status: COMPLETED
Conditions: Hemophilia
Interventions: DRUG: Fitusiran|DRUG: BPA prophylaxis|DRUG: Factor (FVIII or FIX) prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraarterial Stem Cells in Subacute Ischemic Stroke
Status: COMPLETED
Conditions: Ischemic Stroke|MCA Infarction
Interventions: BIOLOGICAL: autologous BMMNC stem cells|OTHER: standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Theranova Versus High-flux Dialyzer on Preservation of Residual Renal Function
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DEVICE: Theranova 400 dialyzer|DEVICE: High-flux dialyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Importance of Gluteus Maximus Muscle in Patients With Preliminary Diagnosis of Piriformis Syndrome
Status: COMPLETED
Conditions: Piriformis Muscle Syndrome|Myofacial Pain Syndromes|Piriformis Syndrome
Interventions: DIAGNOSTIC_TEST: Ultrasound guided piriformis muscle and gluteus maximus muscle lidocaine injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Abemaciclib Dose Escalation to Maintain Intensity (ADE-MI)
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Abemaciclib|DRUG: Abemaciclib|DRUG: Abemaciclib|DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychological Mobile App for Patients With AML
Status: TERMINATED
Conditions: AML|Acute Myeloid Leukemia
Interventions: BEHAVIORAL: DREAMLAND|BEHAVIORAL: CERENA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Early Antiplatelet Administration After Intravenous Thrombolysis for Acute Ischemic Stroke (TREND-IVT)
Status: NOT_YET_RECRUITING
Conditions: Acute Ischemic Stroke|Cerebral Infarction
Interventions: DRUG: Aspirin|DRUG: Placebo|OTHER: Best medical management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Predicting Local and Distant Recurrence in T1 Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer|Colorectal Neoplasms|Colorectal Adenocarcinoma|Colorectal Cancer Stage I|Colorectal Neoplasms Malignant|Colorectal Cancer Recurrent
Interventions: OTHER: Tw1CE
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Naltrexone-Bupropion Versus Placebo-Bupropion for Weight Loss in Schizophrenia
Status: TERMINATED
Conditions: Schizophrenia|Diabetes Mellitus, Type 2|Obesity
Interventions: DRUG: Naltrexone|DRUG: Bupropion|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the FluidVision Accommodating Intraocular Lens (AIOL) With an Improved Injector System
Status: COMPLETED
Conditions: Aphakia
Interventions: DEVICE: FluidVision AIOL|PROCEDURE: Cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Reducing HIV-related Stigma in School Children in Northern Uganda
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV-related Stigma|Health Risk Behaviors|Knowledge, Attitudes, Practice
Interventions: BEHAVIORAL: Arts-based HIV stigma intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of LY2189265 in Japanese Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: LY2189265|DRUG: Placebo|DRUG: Liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Shockwave Therapy for Plantar Fasciitis RCT
Status: ACTIVE_NOT_RECRUITING
Conditions: Plantar Fascitis
Interventions: PROCEDURE: Radial shockwave therapy|PROCEDURE: Focused shockwave therapy|DEVICE: Shockwave therapy device|OTHER: Home therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AeviceMD for Pediatric Asthma Management
Status: NOT_YET_RECRUITING
Conditions: Asthma|Asthma in Children|Pediatric Asthma|Chronic Respiratory Disease
Interventions: DEVICE: AeviceMD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of Cetuximab Versus Cisplatin Early and Late Toxicity Events in HPV+ OPSCC
Status: UNKNOWN
Conditions: Oropharyngeal Squamous Cell Carcinoma
Interventions: DRUG: Cisplatin|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Priming Motor Learning Through Exercise in People With Spinocerebellar Ataxia
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinocerebellar Ataxia Type 1|Spinocerebellar Ataxia Type 2|Spinocerebellar Ataxia Type 3|Spinocerebellar Ataxia Type 6|Spinocerebellar Ataxia Type 7
Interventions: BEHAVIORAL: High-Intensity Aerobic Exercise Prior to Balance Training|BEHAVIORAL: Low-Intensity Exercise Prior to Balance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity of H5N1 Vaccine Following H5N2
Status: COMPLETED
Conditions: Influenza Vaccine
Interventions: BIOLOGICAL: A(H5N1) inactivated influenza vaccine (IIV)|BIOLOGICAL: A(H5N2) live attenuated influenza vaccine (LAIV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Multimodal Instrumented Assessment of Post-stroke Elbow
Status: ENROLLING_BY_INVITATION
Conditions: Spasticity, Muscle|Stroke|Upper Limb
Interventions: DEVICE: Neuroexsos elbow module
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Routine Pressure Wire Assessment Influence Management Strategy at Coronary Angiography for Diagnosis of Chest Pain?
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Radi pressure wire (pressure wire assessment)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Immunotherapy With Dinutuximab Beta in Combination With Chemotherapy for the Treatment of Patients With Primary Neuroblastoma Refractory to Standard Therapy and With Relapsed or Progressive Disease
Status: RECRUITING
Conditions: High-Risk Neuroblastoma
Interventions: COMBINATION_PRODUCT: Chemoimmunotherapy (Dinutuximab beta in combination with chemotherapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stopping Antihypertensive Treatment amOng Hypertensive Patients in Primary Care (STOP-Trial)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Antihypertensive treatment will be stopped for 1 year unless hypertension recurrence
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The TRICURE EU Pivotal Study
Status: NOT_YET_RECRUITING
Conditions: Tricuspid Valve Regurgitation|Heart Valve Disease|Cardiovascular Diseases
Interventions: DEVICE: Transcatheter Tricuspid Valve Replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of GSK Biologicals' Seasonal Influenza Candidate Vaccine (GSK2321138A)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza vaccine GSK2321138A|BIOLOGICAL: FluarixTM|BIOLOGICAL: Influenza vaccine GSK2604409A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Cerebrolysin Combined With Rehabilitation on Motor Recovery in Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: Cerebrolysin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of US-PENS for Patients With Post-surgical Shoulder Pain
Status: RECRUITING
Conditions: Ultrasound-Guided Percutaneous Electrical Nerve Stimulation
Interventions: PROCEDURE: Ultrasound Guied Percutaneus Electrical Nerve Stimulation (US-PENS) and Manual physiotherapy protocol based on available evidence.|PROCEDURE: Manual physiotherapy protocol based on available evidence.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The SCCS Polypill Pilot Trial
Status: COMPLETED
Conditions: Hypertension|Hyperlipidemia
Interventions: DRUG: Polypill (atorvastatin, amlodipine, losartan, and hydrochlorothiazide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison Between Ultra-low-dose Computed Tomography and Lung MRI in Cystic Fibrosis
Status: RECRUITING
Conditions: Cystic Fibrosis
Interventions: DIAGNOSTIC_TEST: CT scanner|DIAGNOSTIC_TEST: Lung MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Chidamide With R-CHOP Regimen for DLBCL Patients
Status: UNKNOWN
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: Chidamide + R-CHOP regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT