pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of Heat-suit Training on Biological and Performance Characteristics in Elite Cyclists
Status: COMPLETED
Conditions: Heat-suit Endurance Training|Non-heat-suit Endurance Training
Interventions: BEHAVIORAL: Heat-suit endurance training|BEHAVIORAL: Non-heat-suit endurance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Absorption of Vitamin D in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DIETARY_SUPPLEMENT: Vitamin D Powder|DIETARY_SUPPLEMENT: Vitamin D Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Clinical Trial of Efficacy and Safety of Ergoferon Versus Oseltamivir in Treatment of Influenza
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: Ergoferon|DRUG: Oseltamivir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Pharmacokinetics of Telotristat Ethyl in Subjects With Severe Hepatic Impairment
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: Telotristat Ethyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coronavirus Disease 2019 (Covid-19) Impact on Alcohol-related Liver Disease Patient Outcomes, Care and Alcohol Use
Status: RECRUITING
Conditions: Liver Diseases|Alcohol Use Disorder
Interventions: BEHAVIORAL: Stepped alcohol intervention (SAT) to reduce unhealthy alcohol use|OTHER: Usual Care (UC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Swallowing Exercises on Patients Undergoing Radiation Treatment for Head and Neck Cancer
Status: TERMINATED
Conditions: Head and Neck Cancer|Stage I Hypopharyngeal Cancer|Stage I Laryngeal Cancer|Stage I Oropharyngeal Cancer|Stage II Hypopharyngeal Cancer|Stage II Laryngeal Cancer|Stage II Oropharyngeal Cancer|Stage III Hypopharyngeal Cancer|Stage III Laryngeal Cancer|Stage III Oropharyngeal Cancer|Stage IV Hypopharyngeal Cancer|Stage IV Laryngeal Cancer|Stage IV Oropharyngeal Cancer
Interventions: BEHAVIORAL: exercise intervention|OTHER: questionnaire administration|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Prevalence Study of Obstructive Sleep Apnea in Subjects With Chest Pain, Positive Exercise Treadmill Test and Normal Coronary Angiogram
Status: TERMINATED
Conditions: Obstructive Sleep Apnea|Cardiac Syndrome X|Endothelial Dysfunction
Interventions: OTHER: no intervention is involved in this study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Association Between Coronary and Peripheral Vascular Injury in Heart Failure Patients With Preserved Ejection Fraction.
Status: NOT_YET_RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: OTHER: Ultrahigh-frequency ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bortezomib and Pegylated Liposomal Doxorubicin in BRCA Wild-type Platinum-resistant Recurrent Ovarian Cancer Patients
Status: UNKNOWN
Conditions: Ovarian Neoplasm Epithelial|High Grade Serous Carcinoma
Interventions: DRUG: Pegylated liposomal doxorubicin plus Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Fibromyalgia With the FibroNova Neuromodulation Device
Status: RECRUITING
Conditions: Fibromyalgia
Interventions: DEVICE: FibroNova (Active mode)|DEVICE: FibroNova (Sham mode)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating Modified Protocols of Oral Immunotherapy to Validate Efficacy and Safety
Status: RECRUITING
Conditions: Peanut Allergy|Milk Allergy, Cow's|Egg Allergy
Interventions: OTHER: Food allergy desensitization / Oral Immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individual Optimal Positive End-expiratory Pressure During Robot-assisted Laparoscopic Radical Prostatectomy
Status: COMPLETED
Conditions: Pulmonary Atelectasis, Postoperative
Interventions: PROCEDURE: Individualized optimal positive end-expiratory pressure|PROCEDURE: Conventional positive end-expiratory pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerance Study of Grass Pollen-derived Peptides to Treat Allergic Rhinitis
Status: COMPLETED
Conditions: Seasonal Allergic Rhinoconjunctivitis
Interventions: BIOLOGICAL: gpASIT+TM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy, Safety and Tolerability of JNJ-42847922 in Participants With Insomnia Disorder Without Psychiatric Comorbidity
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: JNJ-42847922|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Therapy of Umbilical Cord Blood and Erythropoietin for Stroke Paients
Status: UNKNOWN
Conditions: Stroke|Umbilical Cord Blood|Erythropoietin|Safety|Treatment Outcome
Interventions: DRUG: Umbilical cord blood infusion|DRUG: Erythropoietin injection|DRUG: Placebo umbilical cord blood infusion|DRUG: Placebo erythropoietin injection|PROCEDURE: Active rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ENLIGHTEN: Exercise and NutritionaL Interventions for coGnitive and Cardiovascular HealTh ENhancement
Status: COMPLETED
Conditions: Cognitive Impairment, no Dementia (CIND)
Interventions: BEHAVIORAL: Aerobic Exercise|BEHAVIORAL: DASH diet|OTHER: Health education control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cholecalciferol to Improve the Outcomes of COVID-19 Patients
Status: COMPLETED
Conditions: COVID
Interventions: DRUG: Vitamin D|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerance of D-pigment Versus Moisturizer in Hands' Lentigo Lesions With or Without Laser Therapy
Status: COMPLETED
Conditions: Lentigo|Hyperpigmentation
Interventions: OTHER: D-Pigment rich texture|OTHER: Hydrance optimale riche
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Standardized Child Patient Use on Preparing the Child for Process Skill; A Mix Method Study
Status: COMPLETED
Conditions: Anxiety|Pediatric Nursing|Patient Simulation|Self Efficacy|High Fidelity Simulation Training
Interventions: OTHER: simulation with standardized child patient
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Advanced Myelodysplastic Syndrome
Interventions: DRUG: Panobinostat|DRUG: Cytarabine|DRUG: Daunorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heart Health 4 New Moms: A Randomized Trial in the First Year After Preeclampsia
Status: COMPLETED
Conditions: Preeclampsia|Gestational Hypertension|Hypertension|Obesity|Overweight and Obesity|Pregnancy Complications|Pregnancy Toxemia|Postpartum Preeclampsia
Interventions: BEHAVIORAL: Home Blood Pressure Monitoring|BEHAVIORAL: Heart Health 4 New Moms|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Intrapulpal Injections on the Post-endodontic Pain
Status: COMPLETED
Conditions: Pulpitis - Irreversible
Interventions: PROCEDURE: Supplementary anesthetic injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison Between D1 and D2 Lymphadenectomy in Gastric Cancer : A Prospective Randomized Controlled Trial
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: PROCEDURE: D1 or D2 lymphadenectomy for gastric cancer patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pregnancy and Developmental Outcomes After Transfer of Reportedly Aneuploid or Mosaic Embryos
Status: RECRUITING
Conditions: Aneuploidy|Mosaicism
Interventions: OTHER: Non-euploid embryo transfer|OTHER: Euploid Transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of INSORB Staples With Metal Staples in Total Hip Replacement
Status: COMPLETED
Conditions: Erythema|Drainage|Bruising|Pain
Interventions: DEVICE: Insorb staples|DEVICE: metal staples (Ethicon metal stapler)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Administration of TAA-Specific CTLs; Hodgkin or Non-Hodgkin Lymphoma; TACTAL
Status: ACTIVE_NOT_RECRUITING
Conditions: Hodgkin Lymphoma|Non-Hodgkin Lymphoma|Hodgkin Disease
Interventions: BIOLOGICAL: Antigen-Escalation Stage|BIOLOGICAL: Dose-Escalation Stage|BIOLOGICAL: azacytidine and multiTAA T cells Stage|BIOLOGICAL: Pediatric multiTAA T cells Stage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Low-dose Zolpidem in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Zolpidem|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alarm Treatment for Combined Enuresis and Daytime Urinary Incontinence in Children
Status: COMPLETED
Conditions: Incontinence, Urinary|Enuresis, Nocturnal|Enuresis
Interventions: DEVICE: Enuresis Alarm Rodger and Timer watch (Rodger)|DEVICE: Timer watch (Rodger)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Treatment for Cancer Patients With Deep Venous Thrombosis or Pulmonary Embolism
Status: TERMINATED
Conditions: Venous Thromboembolism|Neoplasms
Interventions: DRUG: low molecular weight heparin|DRUG: vitamin K antagonists
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain
Status: COMPLETED
Conditions: Smoking|Nicotine Dependence
Interventions: DRUG: Naltrexone|DRUG: Bupropion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Institutionalization Intervention Impact Project
Status: RECRUITING
Conditions: Socioemotional Development|Cognitive Ability|Behavioral and Neural Patterns of Attention|Brain Function|Psychopathology
Interventions: OTHER: Foster Care|BEHAVIORAL: Caregiving Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate the Safety & Performance of the Xpert(TM) Stent in Treating Below-the-knee Lesions in Patients Undergoing Percutaneous Intervention for Chronic CLI.
Status: COMPLETED
Conditions: Chronic Critical Limb Ischemia|Peripheral Vascular Diseases
Interventions: DEVICE: Xpert(TM) Self-expanding Transhepatic Biliary Stent System feasibility in treating chronic critical limb ischemia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial for the Evaluation of the Treatment and Outcome of Hyperthyroidism With Iodized Salt and Non Iodized Salt
Status: UNKNOWN
Conditions: Hyperthyroidism
Interventions: DIETARY_SUPPLEMENT: Iodine free diet group|DIETARY_SUPPLEMENT: Normal iodine diet group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Strategy Therapy on Cancer Therapy-Related Cardiac Dysfunction
Status: RECRUITING
Conditions: Chemotherapeutic Toxicity|Cardiotoxicity|Heart Failure|Breast Cancer|Lymphoma
Interventions: DRUG: Prevention therapy|DRUG: Rescue therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nebulized hypErtonic Saline for Better Prevention of mUcus pLug in Critical Adult Tracheostomized Patients
Status: UNKNOWN
Conditions: Critical Illness|Tracheostomy Complication|Mechanical Ventilation Complication|Plug; Mucus
Interventions: COMBINATION_PRODUCT: Hypertonic saline of NaCl (7%) in combination with hyaluronic acid|COMBINATION_PRODUCT: Isotonic saline of NaCl (0,9%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Study of Palbociclib in Addition to Standard Endocrine Treatment in Hormone Receptor Positive Her2 Normal Patients With Residual Disease After Neoadjuvant Chemotherapy and Surgery
Status: COMPLETED
Conditions: Breast Cancer|Hormonreceptor Positive|Her2-normal|Postneoadjuvant Treatment With CDK 4/6 Inhibitor|CPS-EG Score
Interventions: DRUG: Palbociclib PD-0332991|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Registry of RESOLUTE-ONYX™ Zotarolimus-eluting Stent Utilization in Percutaneous Small Vessel Coronary Interventionism.
Status: COMPLETED
Conditions: Coronary Disease|Angina, Stable|Ischemia|Acute Coronary Syndrome|Percutaneous Coronary Intervention
Interventions: DEVICE: Percutaneous Coronary Intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomised Controlled Trial Comparing Bone Anchored Hearing Aid With Bonebridge
Status: COMPLETED
Conditions: Hearing Loss, Conductive|Bone Conduction Deafness
Interventions: DEVICE: Bonebridge|DEVICE: Bone Anchored Hearing Aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Repeated Doses of Lu AF35700 on Drug Metabolizing Enzymes
Status: COMPLETED
Conditions: Drug Reactions
Interventions: DRUG: Lu AF35700|DRUG: Midazolam|DRUG: Cocktail of CYP450 substrates
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liver Transplantation Compared to Chemotherapy in Patients With ColoRectal Cancer
Status: RECRUITING
Conditions: Liver Metastases|Colorectal Cancer
Interventions: PROCEDURE: Liver transplantation|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ruxolitinib for Cancer Cachexia
Status: RECRUITING
Conditions: Stage IV Non-small Cell Lung Cancer|Cachexia
Interventions: DRUG: Identify any dose-limiting toxicity (DLT) when ruxolitinib is administered to NSCLC cachexia patients.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Patient Registry Evaluating Closure Following Access With the ArstasisOne Access System
Status: COMPLETED
Conditions: Diagnostic Catheterization Access Through a 5F or 6F Femoral Artery Introducer
Interventions: DEVICE: Diagnostic catheterization procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Esophageal Atresia: a Natural Experiment of the Effects of Oral Inoculation on the Gut Microbiome
Status: COMPLETED
Conditions: Esophageal Atresia
Interventions: OTHER: Patient's own saliva
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Transradial Evaluation Study of Diameter Increase After Vasodilatory Drugs Administration.
Status: COMPLETED
Conditions: Arterial Spasm|Coronary Artery Disease
Interventions: OTHER: Intravenous administration of vasodilatory drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Noninvasive Ventilation on Lung Function in Amyotrophic Lateral Sclerosis
Status: TERMINATED
Conditions: Amyotrophic Lateral Sclerosis|Motor Neuron Disease
Interventions: DEVICE: noninvasive positive pressure ventilation|DEVICE: noninvasive positive pressure ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluate the Effects of a Marine Lipid Oil Concentrate Formulation on Inflammation/Discomfort
Status: COMPLETED
Conditions: Inflammation
Interventions: DIETARY_SUPPLEMENT: Marine Lipid Oil Concentrate Formulation|DIETARY_SUPPLEMENT: Dietary Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Assess the Effects of DPP-4 Inhibition on Insulin Sensitivity in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: CD19-CD22 Chimeric Antigen Receptor T (CAR-T) Cell for Treatment of B Cell Acute Lymphoblastic Leukemia (B-ALL)
Status: UNKNOWN
Conditions: Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: CD19-CD22 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Sitravatinib, Nivolumab and Ipilimumab in Advanced or Metastatic Clear-Cell Renal Cell Carcinoma or Other Solid Malignancies
Status: COMPLETED
Conditions: Clear-Cell Renal Cell Carcinoma
Interventions: DRUG: Sitravatinib|DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of the Safety, PD and PK of a Single Dose of SYN023 Administered With Licensed Rabies Vaccines
Status: COMPLETED
Conditions: Human Rabies
Interventions: BIOLOGICAL: SYN023|BIOLOGICAL: Imovax|BIOLOGICAL: RabAvert|BIOLOGICAL: HyperRAB ST (human rabies immune globulin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effects of Psyllium on Constipation in Schizo-phrenic: A Randomized Controlled Crossover Trial
Status: UNKNOWN
Conditions: Schizophrenia|Psyllium|Constipation
Interventions: DIETARY_SUPPLEMENT: Psyllium huks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Exercise Program for Colorectal Older Patients
Status: RECRUITING
Conditions: Colorectal Neoplasms|Aged
Interventions: PROCEDURE: Enhanced Recovery After Surgery|BEHAVIORAL: Home-based multicomponent exercise program (EXE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lung Lavage With Dilute Poractant Alfa for Meconium Aspiration Syndrome
Status: COMPLETED
Conditions: Meconium Aspiration Syndrome
Interventions: DRUG: Lung lavage with surfactant|DRUG: Bolus surfactant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Condensed Percutaneous Tibial Nerve Stimulation (PTNS) Protocol
Status: TERMINATED
Conditions: Overactive Bladder Syndrome
Interventions: DEVICE: percutaneous tibial nerve stimulation (PTNS)|DEVICE: Sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Mechanisms of the Effects of Psilocybin on Visual Perception and Visual Representations in the Brain
Status: RECRUITING
Conditions: Perception Disorders
Interventions: DRUG: Psilocybin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pilot Study in Participants With Relapsing Remitting Multiple Sclerosis (RR-MS)
Status: TERMINATED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DIETARY_SUPPLEMENT: D-aspartate|DRUG: Placebo|BIOLOGICAL: IFN beta-1a|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Clinical Investigation of a Zinc Based Toothpaste in Reducing Plaque and Gingivitis
Status: COMPLETED
Conditions: Dental Plaque and Gingivitis
Interventions: DRUG: Control toothpaste|DRUG: Experimental toothpaste|DRUG: Active Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Laparoscopic and Open Inguinal Hernia Repair in Elderly Patients
Status: RECRUITING
Conditions: Urinary Retention|Postoperative Complications|Pain|Relapse
Interventions: PROCEDURE: Laparoscopic TEP Repair|PROCEDURE: Open Technique (Lichtenstein)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Huperzine for Cognitive and Functional Impairment in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: placebo|DRUG: huperzine 0.2 mg BID|DRUG: huperzine 0.4 mg BID|DRUG: huperzine 0.8 mg BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of SSD8432 and Ritonavir in Adult Subjects With COVID-19 Clinical Study
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: SSD8432 300mg|DRUG: SSD8432 750mg|DRUG: SSD8432Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Speeding the Weaning up: Aggressive Screening Criteria and Higher Minimal Ventilatory Settings.
Status: COMPLETED
Conditions: Weaning Failure
Interventions: DIAGNOSTIC_TEST: Screening criteria for weaning and minimal ventilatory settings for spontaneous breathing trial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Bioequivalence Study Between Two Oral Formulations of Ibuprofen 800 mg Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Bioequivalency
Interventions: DRUG: Ibuprofen Tablets, 800 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beta Glucan and Acetate Production
Status: COMPLETED
Conditions: Pre Diabetes|Obesity
Interventions: DIETARY_SUPPLEMENT: beta glucan and resistant starch|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: beta gluten
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intubation With McGrath Video Laryngoscope and Boedeker Intubation Foreceps in a Population of Patients With Predictors of Difficult Airway
Status: COMPLETED
Conditions: Patients With One or More Predictors of Difficult Airway
Interventions: DEVICE: Intubation with mcgrath videolaryngoscope and Boedeker intubation foreceps
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Improve Scientific Understanding of the Cardiovascular Actions of Cocaine
Status: WITHDRAWN
Conditions: Cocaine Induced Sympathoexciation and Vasoconstriction
Interventions: DRUG: Cocaine hydrochloride|DRUG: Dexmedetomidine|PROCEDURE: Microneurography|PROCEDURE: Laser doppler velocimetry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Occupation-Based Intervention Compared With Therapeutic Exercise for Older Adults With Shoulder OA.
Status: COMPLETED
Conditions: Osteoarthritis Shoulder
Interventions: PROCEDURE: Therapeutic Exercise|PROCEDURE: Occupation-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Tolerability of Salvia Haenkei Extract as a Dietary Supplement Ingredient
Status: RECRUITING
Conditions: Aging
Interventions: DIETARY_SUPPLEMENT: Salvia haenkei 175mg|DIETARY_SUPPLEMENT: Salvia haenkei 350mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intravaginal Carboxymethyl-β-glucan and Polycarbophil on Low-grade Cervical Lesions (GLUCANCIN)
Status: UNKNOWN
Conditions: Human Papilloma Virus
Interventions: DEVICE: Colpofix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Waitlist-Control Trial of Smartphone Cognitive Behavioral Therapy (CBT) for Body Dysmorphic Disorder (BDD)
Status: COMPLETED
Conditions: Body Dysmorphic Disorder
Interventions: DEVICE: Smartphone-delivered cognitive behavioral therapy (CBT) for body dysmorphic disorder (BDD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: On-Line Intervention to Lower Cardiovascular Risk in Pediatric Heart Transplant Patients
Status: COMPLETED
Conditions: Vascular; Change|Dietary Modification|Physical Activity|Health Behavior|Attitude to Health
Interventions: OTHER: On-Line Diet and Exercise Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids
Status: TERMINATED
Conditions: Uterine Fibroids
Interventions: DRUG: Vilaprisan (BAY1002670)|DRUG: Vilaprisan (BAY1002670)|DRUG: Vilaprisan (BAY1002670)|OTHER: Standard of care|DRUG: Vilaprisan (BAY1002670)|DRUG: Vilaprisan (BAY1002670)|DRUG: Vilaprisan (BAY1002670)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Different Methods for the Diagnosis of Primary Caries Lesions
Status: UNKNOWN
Conditions: Caries Class II
Interventions: PROCEDURE: Visual Inspection|RADIATION: BWX Radiographic Assessment|DEVICE: Assessment of the iTero Element 5D scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: AXP107-11 in Combination With Standard Gemcitabine (Gemzar® ) Therapy for Treatment in Patients With Pancreatic Cancer
Status: UNKNOWN
Conditions: Adenocarcinoma
Interventions: DRUG: AXP107-11
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Acute Hypobaric Hypoxia Exposure on Neurocognitive Performance of Pre-hospital Emergency Service Providers
Status: COMPLETED
Conditions: Hypobaric Hypoxia|Cognitive Deterioration|Emergency Medicine|Resuscitation|Stress Physiology
Interventions: OTHER: Altitude exposure in climate chamber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: MRI Substudy; Metabolic Changes Due to Iatrogenic Hypogonadism
Status: COMPLETED
Conditions: Prostate Cancer|Metabolic Syndrome|Hypogonadism|Fatty Liver
Interventions: DRUG: Triptorelin|PROCEDURE: Orchiectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: p53 Gene Therapy in Treatment of Diabetes Concurrent With Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: HCC|Diabetes
Interventions: DRUG: p53 gene therapy|DRUG: Trans-catheter embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Alpha-galacto-oligasaccharides on Weight Loss in Overweight or Moderately Obeses Adults : A Randomized Controlled Double Blinded Trial Versus Placebo
Status: COMPLETED
Conditions: Randomized Versus Placebo|Controlled|Double Blind
Interventions: DIETARY_SUPPLEMENT: Alpha-galacto-oligosaccharides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CBM588 in Combination With Nivolumab and Cabozantinib for the Treatment of Advanced or Metastatic Kidney Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Clear Cell Renal Cell Carcinoma|Advanced Papillary Renal Cell Carcinoma|Advanced Renal Cell Carcinoma|Advanced Sarcomatoid Renal Cell Carcinoma|Metastatic Clear Cell Renal Cell Carcinoma|Metastatic Papillary Renal Cell Carcinoma|Metastatic Renal Cell Carcinoma|Metastatic Sarcomatoid Renal Cell Carcinoma|Stage III Renal Cell Cancer AJCC v8|Stage IV Renal Cell Cancer AJCC v8|Unresectable Clear Cell Renal Cell Carcinoma|Unresectable Renal Cell Carcinoma
Interventions: DRUG: Cabozantinib S-malate|DRUG: Clostridium butyricum CBM 588 Probiotic Strain|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetic Profiles of Cigarettes and E-Cigarettes With Nicotine Salt Formulations
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: Conventional cigarette|OTHER: myblu 25 mg freebase|OTHER: myblu 16 mg nicotine salt|OTHER: myblu 25 mg nicotine salt|OTHER: myblu 40 mg nicotine salt|OTHER: blu PRO 48 mg nicotine salt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Autologous Mesenchymal Bone Marrow Stromal Cells Secreting Neurotrophic Factors (MSC-NTF), in Patients With Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: BIOLOGICAL: MSC_NTF cells transplantation by multiple intramuscular injections at 24 separate sites, in addition to a single intrathechal injection into the CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy and Safety With CAR-T for Relapsed or Refractory Neuroblastoma in Children
Status: UNKNOWN
Conditions: Relapsed or Refractory Neuroblastoma
Interventions: BIOLOGICAL: GD2-targeted CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chlorhexidine-Metronidazole Combination as an Intracanal Medicament on Periodontal Healing
Status: UNKNOWN
Conditions: Periodontal and Endodontic Lesion
Interventions: PROCEDURE: RCT with CHX-MTZ,OFD|PROCEDURE: RCT with CHX,OFD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Virtual Reality in Patients With Long Covid-19
Status: NOT_YET_RECRUITING
Conditions: COVID-19
Interventions: OTHER: Classical Treatment|OTHER: Virtual Reality Combined with Classical Treatment|OTHER: Virtual Reality|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Nutrient Transit in Hyperinsulinemic Hypoglycemia
Status: RECRUITING
Conditions: Post-Bariatric Hypoglycemia
Interventions: BEHAVIORAL: Use of Continuous Glucose Monitor (CGM)|OTHER: Use of "Cardea Solo" monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cognitive and Motor Training in Pediatric Posterior Fossa Tumor Survivors
Status: COMPLETED
Conditions: Childhood Cancer|Cognitive Impairment|Motor Skills Disorders|Posterior Fossa Tumor
Interventions: OTHER: Cognitive and Motor Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Extracorporeal Shock Wave on Electrophysiological Changes and Pain in Patients With Lower Cross Syndrome
Status: RECRUITING
Conditions: Lower Cross Syndrome
Interventions: OTHER: Extracorporeal shock wave|OTHER: Selected physical therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Telemonitoring for the Management of Side Effects in Patients With Melanoma, Lung or Renal Cancer, Treated With Immunotherapy Combination of Nivolumab and Ipilimumab or Adjuvant Nivolumab Monotherapy
Status: RECRUITING
Conditions: Melanoma|Lung Cancer|Renal Cancer
Interventions: BEHAVIORAL: Tele-monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Placebo-controlled Study of Clenbuterol in Spinal and Bulbar Muscular Atrophy
Status: RECRUITING
Conditions: Spinal and Bulbar Muscular Atrophy
Interventions: DRUG: Clenbuterol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Kinesio Taping on Pain and Disability in Pregnancy-Related Low Back Pain
Status: COMPLETED
Conditions: Pregnancy-related Low Back Pain
Interventions: OTHER: Kinesio tape application and Core stabilization home program|OTHER: Core stabilization home program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of 2.5 mg Chlorhexidine Gluconate Chip (PerioChip®) in Frequent Treatment Versus Routine Treatment in Therapy of Adult Chronic Periodontitis
Status: COMPLETED
Conditions: Generalized Adult Periodontitis
Interventions: DRUG: PerioChip ®
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Genakumab Alone and in Combination With Tislelizumab in Patients With Advanced Malignant Solid Tumors
Status: RECRUITING
Conditions: Malignant Solid Tumors
Interventions: DRUG: Genakumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of PillCam® Express Capsule Endoscopy Delivery System
Status: COMPLETED
Conditions: Small Bowel Disease|Inflammatory Bowel Disease
Interventions: DEVICE: PillCam® Express Capsule Endoscopy Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Cone Beam Computed Tomographic Evaluation of Healing of Apicomarginal Defects Using Autologous Platelet Aggregates
Status: UNKNOWN
Conditions: Chronic Apical Periodontitis
Interventions: PROCEDURE: Periapical surgery using autologous platelet aggregate|PROCEDURE: Periapical surgery without autologous platelet aggregate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Alendronate With β - TCP Bone Substitute in Surgical Therapy of Periodontal Intra-osseous Defects.
Status: COMPLETED
Conditions: Intrabony Periodontal Defect
Interventions: DRUG: Alendronate sodium|BIOLOGICAL: beta-tricalcium phosphate bone substitute
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-label Study to Assess the Long-term Safety and Efficacy of Etelcalcetide (Also Known as AMG 416 or KAI-4169) in Patients With Secondary Hyperparathyroidism
Status: TERMINATED
Conditions: Secondary Hyperparathyroidism
Interventions: DRUG: Etelcalcetide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tracking Biomarkers of Speech Intelligibility
Status: UNKNOWN
Conditions: High-Frequency Hearing Loss
Interventions: BEHAVIORAL: Video Game Training Group 1|BEHAVIORAL: Video Game Training Group 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Individualized Perioperative Open-lung Ventilatory Strategy With High Versus Conventional Inspiratory Oxygen Fraction (iPROVE-O2).
Status: UNKNOWN
Conditions: Hyperoxia|Postoperative Complication|Surgical Site Infection
Interventions: DRUG: High FiO2|DRUG: Conventional FiO2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Comparing the Tolerability and Viral Reduction of the Combination of IFN a-2b XL + Ribavirin Versus Peg IFN a-2b + Ribavirin in Patients With Chronic Hepatitis C, Genotype 1 or 4
Status: UNKNOWN
Conditions: Chronic Hepatitis C
Interventions: DRUG: IFN alfa-2b XL 27 MUI + Ribavirin|DRUG: IFN alfa-2b XL 36 MUI + Ribavirin|DRUG: IFN peg alfa-2b 1.5 µg/kg + Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Anterior and Direct Lateral Approach in Total Hip Arthroplasty
Status: UNKNOWN
Conditions: Coxarthrosis
Interventions: PROCEDURE: Direct lateral approach in total hip arthroplasty|PROCEDURE: Anterior approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intervention Study on Iodine and Molybdenum Biofortification Vegetables ( Nutri-I-Mo )
Status: COMPLETED
Conditions: Healthy Diet
Interventions: DIETARY_SUPPLEMENT: No Intervention: (control group)|DIETARY_SUPPLEMENT: Experimental: intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of SilverHawk®/TurboHawk® in Lower Extremity Vessels (DEFINITIVE™ LE)
Status: COMPLETED
Conditions: Peripheral Arterial Disease|Claudication|Critical Limb Ischemia
Interventions: DEVICE: SilverHawk & TurboHawk Peripheral Plaque Excision System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metabolic, Vascular and Cognitive Effects of Treatment With Anthocyanins
Status: COMPLETED
Conditions: Coronary Disease|Inflammation|Cognitive Impairment
Interventions: DIETARY_SUPPLEMENT: Anthocyanin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: COVID-19 and Reorganisation of Cancer Patient Care: Self- Evaluation of Potential Post-traumatic Stress Disorder
Status: COMPLETED
Conditions: Cancer
Interventions: OTHER: Survey to assess Post traumatic stress and anxiety at inclusion and 6 months later
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of a Humanoid Robot on Dental Anxiety in Children
Status: COMPLETED
Conditions: Behavior, Child
Interventions: BEHAVIORAL: Behavioral guidance with tell-show-do|BEHAVIORAL: Behavioral guidance with robot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ascorbic Acid on Restenosis of Dysfunctional Hemodialysis Vascular Access
Status: COMPLETED
Conditions: Hemodialysis Access Failure
Interventions: DRUG: Ascorbic Acid 300 MG|DRUG: Ascorbic Acid 600 MG|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CERAMENTTM|G and V in the Management of Hip and Knee Arthroplasty Revisions (Revision Arthroplasty Italy)
Status: UNKNOWN
Conditions: Hip Prosthesis Infection|Knee Prosthesis Infection
Interventions: DEVICE: CERAMENT G V
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Flourish HEC on Localized Provoked Vulvodynia
Status: COMPLETED
Conditions: Vulvodynia|Vestibulodynia|Vulvar Diseases|Vulvar Vestibulitis|Vulvar Pain
Interventions: DEVICE: BioNourish, a component of the Flourish HEC kit|OTHER: Control - no intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound as Imaging Biomarker of Early Response to Tocilizumab and Methotrexate in Very Early Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Tocilizumab (TCZ)|DRUG: Methotrexate (MTX)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bivalirudin/Prasugrel Versus Abciximab/Clopidogrel in Patients Presenting With STEMI
Status: UNKNOWN
Conditions: ST-Elevation Myocardial Infarction|Primary Percutaneous Coronary Intervention
Interventions: DRUG: prasugrel/bivalirudin|DRUG: clopidogrel/abciximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Behavioral Activation Prenatal and Postpartum Intervention for Depressed Pregnant Smokers
Status: RECRUITING
Conditions: Depression|Tobacco Use Disorder
Interventions: BEHAVIORAL: Behavioral Activation Therapy|PROCEDURE: Discussion|BEHAVIORAL: Health Education|OTHER: Questionnaire Administration|OTHER: Tobacco Cessation Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Mirabegron OCAS (Oral Controlled Absorption System) in Pediatric Subjects With Neurogenic Detrusor Overactivity or Overactive Bladder
Status: COMPLETED
Conditions: Neurogenic Detrusor Overactivity|Overactive Bladder|Pharmacokinetics of Mirabegron
Interventions: DRUG: Mirabegron
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: 68Ga-FAPI PET/CT in Malignant Tumors
Status: RECRUITING
Conditions: Fibroblast Activation Protein Inhibitor|PET/CT|Malignant Neoplasm
Interventions: DRUG: 68Ga-FAPI|DEVICE: PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Adherence to Oral Therapies in Advanced Breast and Prostate Cancers
Status: RECRUITING
Conditions: Breast Cancer|Prostate Cancer
Interventions: DIAGNOSTIC_TEST: Blood samples|OTHER: Adherence to anti-cancer therapies questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Categorized PT for Non-arthritic Hip and Groin Pain
Status: RECRUITING
Conditions: Hip Pain|Groin Pain
Interventions: OTHER: Matrix-based physical therapy|OTHER: Standard-of-care physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Folic Acid Supplementation in Adolescent Epileptics
Status: UNKNOWN
Conditions: Epilepsy
Interventions: DRUG: Folic Acid|DRUG: Saccharine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION