Clinical trial: Tacrolimus and Mycophenolate Mofetil With or Without Sirolimus in Preventing Acute Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer
Status: COMPLETED
Conditions: Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable|Previously Treated Myelodysplastic Syndrome|Refractory Chronic Lymphocytic Leukemia|Refractory Plasma Cell Myeloma|Waldenstrom Macroglobulinemia|Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3-MLL|Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11|Adult Acute Promyelocytic Leukemia With t(15;17)(q22;q12); PML-RARA|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1|Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative|Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Childhood Acute Lymphoblastic Leukemia in Remission|Childhood Acute Myeloid Leukemia in Remission|Childhood Burkitt Lymphoma|Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Childhood Diffuse Large Cell Lymphoma|Childhood Immunoblastic Lymphoma|Childhood Myelodysplastic Syndrome|Stage II Contiguous Adult Burkitt Lymphoma|Stage II Contiguous Adult Diffuse Large Cell Lymphoma|Stage II Contiguous Adult Diffuse Mixed Cell Lymphoma|Stage II Contiguous Adult Diffuse Small Cleaved Cell Lymphoma|Stage II Adult Contiguous Immunoblastic Lymphoma|Stage II Contiguous Adult Lymphoblastic Lymphoma|Stage II Grade 1 Contiguous Follicular Lymphoma|Stage II Grade 2 Contiguous Follicular Lymphoma|Stage II Grade 3 Contiguous Follicular Lymphoma|Stage II Contiguous Mantle Cell Lymphoma|Stage II Non-Contiguous Adult Burkitt Lymphoma|Stage II Non-Contiguous Adult Diffuse Large Cell Lymphoma|Stage II Non-Contiguous Adult Diffuse Mixed Cell Lymphoma|Stage II Non-Contiguous Adult Diffuse Small Cleaved Cell Lymphoma|Stage II Adult Non-Contiguous Immunoblastic Lymphoma|Stage II Non-Contiguous Adult Lymphoblastic Lymphoma|Stage II Grade 1 Non-Contiguous Follicular Lymphoma|Stage II Grade 2 Non-Contiguous Follicular Lymphoma|Stage II Grade 3 Non-Contiguous Follicular Lymphoma|Stage II Non-Contiguous Mantle Cell Lymphoma|Stage II Small Lymphocytic Lymphoma|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Burkitt Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Recurrent Childhood Hodgkin Lymphoma|Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Secondary Myelodysplastic Syndrome|Stage I Adult Burkitt Lymphoma|Stage I Adult Diffuse Large Cell Lymphoma|Stage I Adult Diffuse Mixed Cell Lymphoma|Stage I Adult Immunoblastic Lymphoma|Stage I Adult Lymphoblastic Lymphoma|Stage I Childhood Anaplastic Large Cell Lymphoma|Stage I Childhood Large Cell Lymphoma|Stage I Childhood Lymphoblastic Lymphoma|Stage I Childhood Burkitt Lymphoma|Stage I Grade 1 Follicular Lymphoma|Stage I Grade 2 Follicular Lymphoma|Stage I Grade 3 Follicular Lymphoma|Stage I Mantle Cell Lymphoma|Stage I Marginal Zone Lymphoma|Stage I Small Lymphocytic Lymphoma|Stage II Childhood Anaplastic Large Cell Lymphoma|Stage II Childhood Lymphoblastic Lymphoma|Stage II Childhood Burkitt Lymphoma|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Immunoblastic Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Childhood Anaplastic Large Cell Lymphoma|Stage III Childhood Large Cell Lymphoma|Stage III Childhood Lymphoblastic Lymphoma|Stage III Childhood Burkitt Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Small Lymphocytic Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Immunoblastic Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Childhood Anaplastic Large Cell Lymphoma|Stage IV Childhood Large Cell Lymphoma|Stage IV Childhood Lymphoblastic Lymphoma|Stage IV Childhood Burkitt Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Small Lymphocytic Lymphoma
Interventions: DRUG: Fludarabine Phosphate|RADIATION: Total-Body Irradiation|PROCEDURE: Peripheral Blood Stem Cell Transplantation|PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Tacrolimus|DRUG: Mycophenolate Mofetil|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT