pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Treatment of Obstructive Sleep Apnea With Continuous Positive Airway Pressure on Appearance and Age
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: continuous positive airway pressure|OTHER: Breathe Right ®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SAT vs Escitalopram for Rectal Hypersensitivity
Status: COMPLETED
Conditions: Rectal Hypersensitivity|Irritable Bowel Syndrome-Constipation
Interventions: PROCEDURE: Sensory Adaptation Training|DRUG: Escitalopram Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Trastuzumab Emtansine (Kadcyla) Plus Pertuzumab (Perjeta) Following Anthracyclines in Comparison With Trastuzumab (Herceptin) Plus Pertuzumab and a Taxane Following Anthracyclines as Adjuvant Therapy in Participants With Operable HER2-Positive Primary Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab Emtansine|DRUG: Trastuzumab|DRUG: Pertuzumab|DRUG: Paclitaxel|DRUG: Epirubicin|DRUG: Doxorubicin|DRUG: Docetaxel|DRUG: Cyclophosphamide|DRUG: 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VR Augmented Human Delivered Integrative Psychotherapy for Colonoscopy Procedural Anxiety and Pain
Status: ENROLLING_BY_INVITATION
Conditions: Procedural Anxiety|Procedural Pain
Interventions: BEHAVIORAL: Virtual Reality Integrative Psychotherapy|DEVICE: Virtual Reality Distraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Do Patients Who Received Tranexamic Acid in Vaginal Hysterectomy Loose Les Blood, Comparing to Patients Who Did Not?
Status: RECRUITING
Conditions: Vaginal Hysterectomy
Interventions: DRUG: Tranexamic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Transvaginal Tension Free Vaginal Tape-Obturator (TVT-O) Versus Transobturator Tape-Mentor (TOT) in the Management of Urodynamic Stress Urinary Incontinence
Status: UNKNOWN
Conditions: Urinary Stress Incontinence
Interventions: DEVICE: Transobturator tape-ARIS|DEVICE: TVT-O
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Individualized vs. Household MRSA Decolonization
Status: COMPLETED
Conditions: Staphylococcal Skin Infection|Abscess|Furunculosis|Staphylococcus Aureus|MRSA Infection
Interventions: DRUG: 2% mupirocin ointment|OTHER: Bleach Bath (dilute)|BEHAVIORAL: Hygiene Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Social Skills and Anxiety Reduction Treatment for Children and Adolescents With Autism Spectrum Disorders
Status: COMPLETED
Conditions: Autistic Disorder|Child Development Disorders, Pervasive
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy (CBT) Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lansoprazole in Preterm Infants With Gastroesophageal Reflux (GER)
Status: COMPLETED
Conditions: Premature Infants|Gastroesophageal Reflux
Interventions: DRUG: Lansoprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nutritional Supplementation and Muscle Health: A Pilot Study on Immune Function
Status: COMPLETED
Conditions: Immunosenescence|Sarcopenia
Interventions: DIETARY_SUPPLEMENT: Muscle Armor Supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Effect of STC314 Injection Continuous Infusion in Subjects With Acute Respiratory Distress Syndrome
Status: UNKNOWN
Conditions: Acute Respiratory Distress Syndrome
Interventions: DRUG: STC314 injection or Placebo(rate=58.3 mg/hr)|DRUG: STC314 injection or Placebo(rate=87.5 mg/hr)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Central Venous Pressures (CVPs) Measured From Peripherally Inserted Central Catheters (PICC) and CICC in Liver Transplantation Recipients
Status: COMPLETED
Conditions: Patients Cannulated With Both PICC and CICC.|The Rapidly Fluctuating Hemodynamics During LT.
Interventions: DEVICE: PICC, CICC
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sufficient Chemotherapy Combine With Maintenance Chemotherapy in the Treatment of Oligometastatic Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Capecitabine/S-1|DRUG: Chemotherapy|RADIATION: Head and neck radiotherapy|OTHER: Local Consolidative Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-dose Atropine for the Prevention of Myopia Progression in Danish Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Myopia
Interventions: DRUG: 0.1% atropine and 0.01% atropine|DRUG: 0.01% atropine|DRUG: 0.9% Sodium-chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Evaluation of AN2690 Topical Solution to Treat Onychomycosis of the Toenail
Status: COMPLETED
Conditions: Onychomycosis of Toenails
Interventions: DRUG: AN2690 Topical Solution, 5%|DRUG: Solution Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Bioavailability Study With Alternate Methods of Administration of Naloxegol Tablets, and Solution
Status: COMPLETED
Conditions: Bioavailability|Healthy Subjects
Interventions: DRUG: Naloxegol 25 mg tablet, crushed, suspended in water, given orally|DRUG: Naloxegol 25mg tablet crushed, suspended in water, given via nasogastric tube|DRUG: Naloxegol 25 mg (10 mL oral solution)|DRUG: Naloxegol 25 mg tablet, given orally
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of Alfuzosin in Stone Treatment With ESWL
Status: WITHDRAWN
Conditions: Urinary Calculi
Interventions: DRUG: Alfuzosin (Xatral)|DRUG: standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Characterization of Dienogest
Status: COMPLETED
Conditions: Pharmacodynamics
Interventions: DRUG: Dienogest (81150037)|DRUG: Dienogest (81150231)|DRUG: Dienogest (SH T00660A)|DRUG: Dienogest (81150746)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Efficacy of Modified Piezosurgery Alveolar Bone Cut With Osseodensification Drills in Expanding Narrow Alveolar Bone
Status: COMPLETED
Conditions: Dental Implant Failed
Interventions: DEVICE: measurement of alveolar ridge width
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability and Efficacy of LCZ696 in Japanese Severe Hypertensive Patients
Status: COMPLETED
Conditions: Severe Hypertension
Interventions: DRUG: LCZ696|DRUG: LCZ696|DRUG: LCZ696
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Sinovuyo Caring Families Project: a Randomized Controlled Trial of a Parenting Programme
Status: COMPLETED
Conditions: Child Behaviour Problems
Interventions: BEHAVIORAL: Sinovuyo Caring Families Programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Nitrate on Red Blood Cell Function in Type 2 Diabetes
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Beet root juice|DIETARY_SUPPLEMENT: Placebo juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effects of the Intrapartum Care Model Given in Line With the Recommendations of the World Health Organization (WHO)
Status: COMPLETED
Conditions: Birth Outcome, Adverse|Breast Feeding|Parenting
Interventions: OTHER: Intrapartum Care Model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Modified Method for Blind Bedside Placement of Post-pyloric Feeding Tube.
Status: COMPLETED
Conditions: Nutritional Support, Catheterization, Post-pyloric Feeding Tube, Dysphagia
Interventions: PROCEDURE: A modified method for blind bedside placement of post-pyloric feeding tube.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Antidepressant Medication Plus Donepezil for Treating Late-life Depression
Status: COMPLETED
Conditions: Depression|Dementia
Interventions: DRUG: Escitalopram|DRUG: Donepezil|DRUG: Venlafaxine|DRUG: Placebo|DRUG: Duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GoalKeeper: Intelligent Information Sharing for Children With Medical Complexity
Status: COMPLETED
Conditions: Childhood Cancer|Cerebral Palsy|Chronic Lung Disease|Congenital Heart Disease|Congenital Metabolic Disorder|Gastrostomy
Interventions: OTHER: GoalKeeper|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: JX09 SAD/MAD in Healthy Participants
Status: RECRUITING
Conditions: Resistant Hypertension
Interventions: DRUG: JX09 or placebo SAD|DRUG: JX09 or placebo MAD|DRUG: JX09
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Rencofilstat in Subjects With NASH and Advanced Liver Fibrosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Nonalcoholic Steatohepatitis (NASH)|Fibrosis, Liver|NAFLD
Interventions: DRUG: Rencofilstat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerance and Growth Outcomes in Children Diagnosed With Cow's Milk Protein Allergy and Prescribed an Extensively Hydrolyzed Casein Formula (Damira 2000©) in Spain
Status: COMPLETED
Conditions: Cow's Milk Protein Allergy
Interventions: OTHER: Damira 2000 Infant formula
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of the Serious Video Game MOON in Emotional Regulation in ADHD
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: The Secret Trail of Moon (MOON): Cognitive training with Serious Video Game|DRUG: Usual treatment for ADHD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Titration of Intraoperative PEEP in Patients Undergoing Robotic Assisted Laparoscopic Prostatectomy
Status: COMPLETED
Conditions: Positive End Expiratory Pressure
Interventions: OTHER: Titration of Optimal Positive End-expiratory Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Verify the Clinical Benefit of Aducanumab in Participants With Early Alzheimer's Disease
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: Aducanumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cerebral Palsy: Ankle Foot Orthoses - Footwear Combinations
Status: COMPLETED
Conditions: Cerebral Palsy (CP)
Interventions: OTHER: Ankle Foot Orthoses-Footwear Combination|OTHER: Traditional Solid Ankle AFO (TSAFO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Plus Low Dose Morphine Versus Standard Dose of Morphine in PCA in Children .
Status: RECRUITING
Conditions: PCA|Children|Dexmedetomidine|Morphine
Interventions: DRUG: standard dose morphine|DRUG: low dose morphine plus dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Serum Based Diagnosis of and Monitoring of Infection Recovery in Orthopedic Spine Implant Infections
Status: ENROLLING_BY_INVITATION
Conditions: Staphylococcus Aureus Infection|Surgical Site Infection|Orthopedic Procedures|Spine
Interventions: DIAGNOSTIC_TEST: Medium enriched for newly synthesized antibodies in spine infection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Evaluate the Efficacy and Safety of Micafungin in Preventing Invasive Mycosis After Liver Transplantation
Status: NOT_YET_RECRUITING
Conditions: Liver Transplantation
Interventions: DRUG: Micafungin Sodium 50 MG Injection|DRUG: Caspofungin Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Co-treatment on Endometrial abv3-integrin Expressions in Women With Recurrent Implantation Failure
Status: COMPLETED
Conditions: Miscarriage, Recurrent
Interventions: DRUG: GNRH Analoge, Duphaston, Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Blood Flow Restriction Training in Rotator Cuff Related Shoulder Pain
Status: WITHDRAWN
Conditions: Subacromial Pain Syndrome
Interventions: OTHER: Side-lying external rotation exercise with a dumbbell|OTHER: Side-lying external rotation exercise with a dumbbell with 40% arterial occlusion pressure blood flow restriction|OTHER: Side-lying external rotation exercise with a dumbbell with 80% arterial occlusion pressure blood flow restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study II
Status: RECRUITING
Conditions: Cannabis
Interventions: DRUG: Inhaled THC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Dose-response Trial Using FE 999049 in Japanese Women Undergoing in Vitro Fertilisation (IVF) / Intracytoplasmic Sperm Injection (ICSI) Treatment
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: FE 999049|DRUG: follitropin beta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Cross-sectional Area of the Long Head of the Biceps Tendon and the Rotator Cuff Tear Position
Status: UNKNOWN
Conditions: Rotator Cuff Tears
Interventions: PROCEDURE: Arthroscopic rotator cuff repair
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Anthropometric, Biochemical and DNA Damage Parameters After 3-weeks VLCD in Severely Obese Patients
Status: COMPLETED
Conditions: Obesity|Weight Loss|DNA Damage
Interventions: DEVICE: Very low calorie diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Pembrolizumab, Chemotherapy and Bevacizumab in Patients With Cervical Cancer
Status: TERMINATED
Conditions: Cervical Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Paclitaxel|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess Continued Safety of and Adherence to the Dapivirine (25 mg) Vaginal Ring-004 in Healthy, HIV-negative Women
Status: COMPLETED
Conditions: HIV Prevention
Interventions: DRUG: Dapivirine Vaginal Ring-004
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Clinical Evaluation of the Intersect ENT Sinus Device (ASCEND)
Status: COMPLETED
Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: DEVICE: Drug-Coated Device|DEVICE: Control Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sudapyridine (WX-081) in RR/MDR/XDR-tuberculosis Patients
Status: ENROLLING_BY_INVITATION
Conditions: Rifampicin-resistant Tuberculosis
Interventions: DRUG: Sudapyridine|DRUG: Bedaquiline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BI-754091 and Afatinib for Refractory Esophageal Squamous Cell Carcinoma (BEAR Study)
Status: COMPLETED
Conditions: Esophageal Squamous Cell Carcinoma (ESCC)
Interventions: DRUG: BI-754091 plus afatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simvastatin Therapy for Moderate and Severe COPD
Status: TERMINATED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Olaparib and Temozolomide in Treating Patients With Relapsed Glioblastoma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: olaparib|DRUG: temozolomide|GENETIC: gene expression analysis|GENETIC: protein expression analysis|OTHER: laboratory biomarker analysis|OTHER: pharmacological study|PROCEDURE: diffusion-weighted magnetic resonance imaging|PROCEDURE: dynamic contrast-enhanced magnetic resonance imaging|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Abiraterone Acetate in Male Participants With Mild or Moderate Hepatic Impairment Compared to Matched Control Participants With Normal Hepatic Function
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Abiraterone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Perioperative Oral Nutritional Supplementation on Patients Undergoing Hepatic Surgery for Liver Cancer
Status: TERMINATED
Conditions: Liver Cancer|Hepatocellular Carcinoma|Cirrhosis|Liver Fibrosis
Interventions: DRUG: Oral Impact®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of a Multi-intervention Program and Protein Food Sources on Preventing and Mitigating Sarcopenia
Status: RECRUITING
Conditions: Sarcopenia|Dietary Exposure|Nutrition, Healthy
Interventions: DIETARY_SUPPLEMENT: multi-intervention program and protein foods supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: TAEK-VAC-HerBy Vaccine for Brachyury and HER2 Expressing Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Chordoma|HER2-positive Breast Cancer|HER2-positive Gastric/Gastroesophageal Junction Cancer
Interventions: BIOLOGICAL: TAEK-VAC-HerBy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term F/U Studies at Y5&6 to Demonstrate the Equivalence of 2 Vaccination Schedules of Combined Hepatitis A & B Vaccine
Status: COMPLETED
Conditions: Hepatitis B|Hepatitis A
Interventions: BIOLOGICAL: Combined Hepatitis A and B vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dietary Reduction of AGEs to Prevent Cognitive Decline in Elderly Diabetics
Status: COMPLETED
Conditions: Cognitive Decline|Aging|Type 2 Diabetes
Interventions: BEHAVIORAL: Low AGEs diet|BEHAVIORAL: Standard of care dietary guidance for Type 2 diabetes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Detachment of the Breathing Circuit on the Rate of DLT Malposition After Postural Change
Status: NOT_YET_RECRUITING
Conditions: Intratracheal Intubation|Patient Positioning
Interventions: BEHAVIORAL: Disengage the breathing circuit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Tolerance and Efficacy Evaluation of 3 Face Creams
Status: UNKNOWN
Conditions: Skin Aging
Interventions: OTHER: Soothing (formulation number: F#1048-082) and antiaging creams (F#841-020 and F#1374-002)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Incidence of Postthoracotomy Pain Following General Anesthesia: A Comparison Between TIVA and Inhalation Anesthesia
Status: UNKNOWN
Conditions: Lung Cancer|Neoplasms, Lung
Interventions: DRUG: propofol, remifentanil, sevoflurane
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Capecitabine and Temozolomide for Treatment of Recurrent Pituitary Adenomas
Status: TERMINATED
Conditions: Recurrent Pituitary Adenomas
Interventions: DRUG: Capecitabine|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Forced Oscillations for Diagnosis Help in Bronchiolitis Obliterans Syndrome in Post Bone Marrow Transplantation
Status: COMPLETED
Conditions: Bronchiolitis Obliterans|Bone Marrow Transplantation
Interventions: OTHER: Forced oscillations measure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treatment of Multiple Sclerosis and Neuromyelitis Optica With Regulatory Dendritic Cell: Clinical Trial Phase 1 B
Status: COMPLETED
Conditions: Multiple Sclerosis|Neuromyelitis Optica
Interventions: BIOLOGICAL: Tolerogenic Dendritic cells loaded with myelin peptides
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ICG and SLN Mapping
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: SLN mapping using technetium-99m +/- isosulfan blue dye|DEVICE: SLN mapping with ICG fluorescence using the Asimov Platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long COVID-19 [11C]CPPC Study
Status: RECRUITING
Conditions: COVID Long-Haul
Interventions: DRUG: [11C]CPPC Injection|DRUG: [11C]CPPC Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study on the Safety and Effectiveness of the SnowyTM PFO Closure System
Status: NOT_YET_RECRUITING
Conditions: Patent Foramen Ovale
Interventions: DEVICE: SnowyTM PFO closure system|DEVICE: Cardi-o-fix PFO occluder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of the Safety and Effectiveness of the Mentor Larger Size MemoryGel Ultra High Profile Breast Implants in Subjects Who Are Undergoing Primary Breast Reconstruction or Revision Reconstruction
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Reconstruction, Revision Breast Reconstruction
Interventions: DEVICE: Mentor Larger Size MemoryGel Ultra High Profile Breast Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lutonix® DCB for Treatment of Long Lesions in Femoropopliteal Arteries
Status: COMPLETED
Conditions: Femoral Artery Occlusion|Femoral Arterial Stenosis
Interventions: DEVICE: Lutonix Paclitaxel Drug Coated Balloon (DCB)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Use of Proton Pump Inhibitor for the Treatment of Non-erosive Gastro-oesophageal Reflux Disease in Chinese Population
Status: UNKNOWN
Conditions: Gastroesophageal Reflux
Interventions: DRUG: Esomeprazole 20mg once daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Anidulafungin Versus Fluconazole for the Prevention of Fungal Infections in Liver Transplant Recipients
Status: COMPLETED
Conditions: Mycoses|Fungemia|Central Nervous System Fungal Infections|Lung Diseases, Fungal
Interventions: DRUG: Anidulafungin|DRUG: Fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Antibacterial Effect of Allium Sativum, Calcium Hydroxide and Their Combination in Infected Mature Teeth
Status: COMPLETED
Conditions: Drug Effect
Interventions: DRUG: Allium Sativum|DEVICE: Polymerase chain reaction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ATH-063 in Healthy Subjects
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases|Crohn Disease|Ulcerative Colitis|Autoimmune Diseases
Interventions: DRUG: ATH-063|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI)
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Alzheimer's Disease|Traumatic Brain Injury
Interventions: BEHAVIORAL: Mnemonic strategy training (MST)|BEHAVIORAL: Repeated exposure (XP)|BEHAVIORAL: Subtracting Cues training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab With and Without Radiotherapy for Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Pembrolizumab|RADIATION: stereotactic radiation therapy (SRT)|PROCEDURE: Surgery (Non-interventional, standard of care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Microbiological Evaluation of Periodontal Treatment of Diabetic Patients: A Longitudinal Study
Status: UNKNOWN
Conditions: Chronic Periodontitis|Diabetes Mellitus, Type 2
Interventions: PROCEDURE: Full Mouth Scaling and Root Planing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination Study Of S-555739/Cetirizine HCl In Adult Patients With Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: S-555739 Dose 1|DRUG: S-555739 Dose 2|DRUG: Cetirizine HCl Dose 1|DRUG: S-555739 placebo|DRUG: Cetirizine HCl placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Ciprofol in Cardiac Surgery Anesthesia
Status: RECRUITING
Conditions: Anesthesia
Interventions: DRUG: ciprofol injection|DRUG: Propofol injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: RCT Examining the Effectiveness of Digital Picture Frame Use in Inpatient Setting
Status: COMPLETED
Conditions: Schizophrenia|Psychosis|Psychosis NOS
Interventions: BEHAVIORAL: Digital Picture Frame|BEHAVIORAL: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Anal Fistula Plug Versus Endorectal Advancement Flap
Status: UNKNOWN
Conditions: Anal Fistula
Interventions: PROCEDURE: Anal Fistula Plug|PROCEDURE: Endorectal Advancement Flap
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MK0429 Study in Prostate Cancer Patients With Metastatic Bone Disease (0429-011)
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: Comparator: MK0429|DRUG: Comparator: MK0429|DRUG: Comparator: MK0429|DRUG: Comparator: MK0429
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Positive Expiratory Pressure Breathing on The Rate of Post-exercise Recovery in Patients With COPD
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: A water pressure threshold device (BreatheMAX)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intrathecal Additives for Spinal Anaesthesia in Elective Caesarean Sections
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: intrathecal Magnesium|DRUG: intrathecal dexamthasone|DRUG: intrathecal dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Intermittent Fasting in Hypertriglyceridemic Overweight or Obese Subjects
Status: COMPLETED
Conditions: Hypertriglyceridemia|Overweight or Obesity
Interventions: OTHER: intermittent fasting diet|OTHER: low calorie diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Bioequivalence of Famotidine/Antacid Combination Tablets Compared to Famotidine/Antacid EZ Chew Tablets (0208C-145)(COMPLETED)
Status: COMPLETED
Conditions: Heartburn
Interventions: DRUG: famotidine (+) calcium carbonate (+) magnesium hydroxide tablet|DRUG: Comparator: famotidine (+) calcium carbonate (+) magnesium hydroxide EZ Chew tablet without water|DRUG: Comparator: famotidine (+) calcium carbonate (+) magnesium hydroxide EZ Chew tablet with water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Inhaled Ciclesonide Versus Fluticasone Propionate Versus Placebo on Lower Leg Growth in Prepubertal Children With Mild Persistent Asthma (6 to 12 y) (BY9010/M1-208)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Ciclesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Multidimensional Intervention in Pre-frail Patients Older Than 70 Years
Status: UNKNOWN
Conditions: Frail Elderly Syndrome|Sarcopenia
Interventions: BEHAVIORAL: Intensive dietary advice and exercise prescription|BEHAVIORAL: Usual dietary advice and exercise prescription
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CHOICES-TEEN Randomized Controlled Trial
Status: RECRUITING
Conditions: Risk for an Alcohol-Exposed Pregnancy|Risk for Marijuana-Exposed Pregnancy|Risk for Substance-Exposed Pregnancy|HIV Risk|Sexually Transmitted Infection Risk
Interventions: OTHER: CHOICES-TEEN|OTHER: Health and Life Skills Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Colesevelam Versus Placebo in Cholestatic Pruritus
Status: COMPLETED
Conditions: Chronic Liver Disease
Interventions: DRUG: colesevelam|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy Young Individuals
Status: COMPLETED
Conditions: Dietary Supplementation
Interventions: DIETARY_SUPPLEMENT: Grape seed extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Progressive Muscle Relaxation Exercise Training Given to Pregnant Women With Restless Leg Syndrome
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: BEHAVIORAL: progressive muscle relaxation exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)
Status: RECRUITING
Conditions: Obstructive Sleep Apnea|Down Syndrome
Interventions: PROCEDURE: DISE-Directed Surgery|PROCEDURE: Adenotonsillectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coriandrum Sativum Seeds Improve Memory, Alleviate Anxiety and Depression, and Enhance Sleep Quality in University Students: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Memory Disorders|Anxiety Depression|Sleep
Interventions: DIETARY_SUPPLEMENT: Coriandrum sativum seeds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: E-cigarette Nicotine Study
Status: COMPLETED
Conditions: Nicotine Dependence|Electronic Cigarette Use|Cigarette Smoking
Interventions: DRUG: Nicotine|DEVICE: Juul e-cigarette|BEHAVIORAL: Reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Shockwave Therapy for Acute Low Back Pain
Status: COMPLETED
Conditions: Acute Low Back Pain (Low Back Pain for Less Than 3 Months)
Interventions: DEVICE: shockwave therapy|DEVICE: placebo shockwave therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Occludin and Zonulin in Attention-deficit/Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention-deficit/Hyperactivity Disorder
Interventions: DIAGNOSTIC_TEST: Zonulin|DIAGNOSTIC_TEST: Occludin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Improving the Reach & Effectiveness of Smoking Cessation Services Targeted to Veterans Living With HIV
Status: RECRUITING
Conditions: HIV Infections|Smoking|Smoking Cessation
Interventions: BEHAVIORAL: Wellness Intervention for Smokers with HIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Digestive Tolerability of ART44 Versus ART®50 in Patients With Osteoarthritis of the Knee
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DRUG: ART 44|DRUG: ART 50
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Metformin Hydrochloride 500 mg Film-Coated Tablets in Indonesia Healthy Subject
Status: COMPLETED
Conditions: Drug Use
Interventions: DRUG: Metformin Hydrochloride 500 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of 18-month Regimen Containing 6 Anti-tuberculosis Drugs for Patients With MDR-TB
Status: COMPLETED
Conditions: Multi-drug Resistant Tuberculosis
Interventions: DRUG: 18-month regimen containing 6 anti-TB drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Methadone Compared to Placebo in Elderly Hip Fracture Patients
Status: RECRUITING
Conditions: Hip Fractures|Methadone
Interventions: DRUG: Methadone Hydrochloride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of P38 Inhibitor (4) in Patients With Active Rheumatoid Arthritis (RA) on Stable Methotrexate Therapy
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: P38 Inhibitor (4) 150mg|DRUG: P38 Inhibitor (4) 25mg|DRUG: P38 Inhibitor (4) 300mg|DRUG: P38 Inhibitor (4) 50mg|DRUG: P38 Inhibitor (4) 75mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Study of BK Virus Disease After Allogeneic Hematopoietic-cell Transplantation: Defining BK Disease's Natural History, Clinical Spectrum, Immunology, and Outcomes
Status: COMPLETED
Conditions: BK Virus Infection
Interventions: OTHER: Symptom index questionnaire|DIAGNOSTIC_TEST: BK polyomavirus PCR|OTHER: quality of life questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Omiganan Twice a Day (BID) in Patients With Facial Seborrheic Dermatitis
Status: UNKNOWN
Conditions: Seborrheic Dermatitis
Interventions: DRUG: Omiganan|DRUG: Ketoconazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Doppler to Diagnose Myometrial Masses
Status: UNKNOWN
Conditions: Uterine Masses
Interventions: OTHER: Three dimensional Power Doppler to the myometrial mass|OTHER: Uterine artery Doppler
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Individualized Incremental Hemodialysis Study
Status: COMPLETED
Conditions: Hemodialysis Complication|ESRD|Renal Failure
Interventions: PROCEDURE: Individualized Incremental hemodialysis|PROCEDURE: Conventional thrice weekly hemodialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Epidural Steroid Injection (ESI) Versus Minimally Invasive Lumbar Decompression (Mild®) in Patients With Symptomatic Lumbar Central Canal Stenosis
Status: COMPLETED
Conditions: Lumbar Spinal Stenosis
Interventions: DEVICE: MILD® (Minimally Invasive Lumbar Decompression)|DRUG: Epidural Steroid Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy and Safety of PTC299 (Emvododstat) in Hospitalized Participants With Coronavirus (COVID-19)
Status: TERMINATED
Conditions: Pneumonia|COVID-19|Coronavirus
Interventions: DRUG: PTC299|OTHER: SOC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Type H Vessel Formation in Induced Membrane of Patients With Critical Size Bone Defect
Status: NOT_YET_RECRUITING
Conditions: Bone Injury
Interventions: PROCEDURE: induced membrane technique|PROCEDURE: Bone graft (Stage II of IMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Upper Airway Reeducation in Moderate Obstructive Sleep Apnea Syndrome
Status: NOT_YET_RECRUITING
Conditions: Moderate Obstructive Sleep Apnea Syndrome
Interventions: OTHER: Experimental|OTHER: Sham comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tramadol Versus Celecoxib for Reducing Pain During Operative Office Hysteroscopy
Status: UNKNOWN
Conditions: Hysteroscopy
Interventions: DRUG: Celecoxib|DRUG: Tramadol|DRUG: Placebo 1|DRUG: Placebo 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of AK002 in Patients With Eosinophilic Gastritis and/or Eosinophilic Gastroenteritis
Status: COMPLETED
Conditions: Eosinophilic Gastritis|Eosinophilic Gastroenteritis
Interventions: DRUG: AK002|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-acting Injectable Risperidone in Patients With Schizophrenia After an Acute Episode
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: early initiation of treatment with Risperdal Consta|DRUG: routine initiation of treatment with Risperdal Consta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Intravitreous Injections of Vitrase for Inducing Posterior Vitreous Detachment
Status: COMPLETED
Conditions: Vitreous Detachment|Diabetic Retinopathy
Interventions: DRUG: Vitrase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Catheter Ablation Versus Medical Treatment of AF in Heart Failure
Status: UNKNOWN
Conditions: Atrial Fibrillation|Heart Failure
Interventions: PROCEDURE: Catheter ablation of persistent atrial fibrillation|DRUG: Medical treatment alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Efficacy of Rest-ZZZ Formula in Healthy Participants With Difficulty Falling Asleep or Staying a Sleep
Status: COMPLETED
Conditions: Sleep|Healthy
Interventions: DIETARY_SUPPLEMENT: Rest-ZZZ|DRUG: Active Comparator - Diphenhydramine HCl|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Topotecan, G-CSF, and Radiation Therapy in Treating Young Patients With Newly Diagnosed Brain Stem Glioma
Status: TERMINATED
Conditions: Brain Tumors|Central Nervous System Tumors
Interventions: BIOLOGICAL: filgrastim|DRUG: topotecan hydrochloride|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: [18F]MC225-PET in Neurodegenerative Disease
Status: RECRUITING
Conditions: Neurodegenerative Diseases|Alzheimer Disease|Parkinson Disease|Mild Cognitive Impairment
Interventions: DRUG: [18F]MC225
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Carbonated Soft Drinks on Appetite-Regulation
Status: COMPLETED
Conditions: Obesity|Diet
Interventions: OTHER: Sugar-sweetened soft drink|OTHER: Aspartame-sweetened soft drink|OTHER: Semi-skimmed milk|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Dapagliflozin Versus Glimepiride Effect in Patient With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Dapagliflozin 5Mg Tab|DRUG: Glimepiride 4Mg Tab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p