pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Myoinositol Supplementation, Insulin Resistance and Fetal Sonographic Parameters in Gestational Diabetes Diet Treated
Status: COMPLETED
Conditions: Gestational Diabetes
Interventions: DIETARY_SUPPLEMENT: Myoinositol|DIETARY_SUPPLEMENT: Placebo (for myoinositol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Comparing Aquaphor to Atopiclair and EpiCeram in Children With Mild to Moderate Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Atopiclair Nonsteroidal Cream|OTHER: Aquaphor Healing Ointment|DRUG: EpiCeram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, PK, PD, Immunogenicity & Antitumor Activity of MSC-1 in Patients With Adv Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors|Pancreatic Cancer|Non Small Cell Lung Cancer|Ovarian Cancer
Interventions: BIOLOGICAL: MSC-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study of Electrical Acupuncture Stimulation Therapy for Postprostatectomy Incontinence
Status: UNKNOWN
Conditions: Postprostatectomy Incontinence
Interventions: DEVICE: Electrical Acupuncture Stimulation|DEVICE: sham Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Denosumab on Inflammatory Osteolytic Lesion Activity in Total Hip Arthroplasty
Status: COMPLETED
Conditions: Revision Surgery of Total Hip Arthroplasty
Interventions: DRUG: Denosumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-PD-L1 Armored Anti-CD22 CAR-T/CAR-TILs Targeting Patients With Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor, Adult|Cervical Cancer|Sarcoma|NSCLC
Interventions: BIOLOGICAL: Autologous aPD-L1 armored anti-CD22 CAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetic Mutations and Environmental Exposure in Young Patients With Retinoblastoma and in Their Parents and Young Healthy Unrelated Volunteers
Status: COMPLETED
Conditions: Extraocular Retinoblastoma|Intraocular Retinoblastoma|Recurrent Retinoblastoma
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate Efficacy and Safety of Subcutaneous Abatacept With Steroid Treatment Compared to Steroid Treatment Alone in Adults With Giant Cell Arteritis (GCA)
Status: WITHDRAWN
Conditions: Giant Cell Arteritis
Interventions: DRUG: Abatacept|OTHER: Placebo|DRUG: Glucocorticoid Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-Venous Acetaminophen and Muscle Relaxants After Total Knee
Status: COMPLETED
Conditions: Unilateral Knee Arthroplasty
Interventions: DRUG: Preop acetaminophen IV|DRUG: Preop orphenadrine IV|DRUG: Postop oral oxycodone & acetaminophen|DRUG: Postop hydromorphone IV|DRUG: Postop oral orphenadrine|DRUG: Postop oral oxycodone|DRUG: Postop acetaminophen IV|DRUG: Postop orphenadrine IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In Vitro And Ex Vivo Anti-Inflammatory Activities Of Salmon Polar Lipids
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DIETARY_SUPPLEMENT: Food supplement capsules containing Salmon-Polar Lipids|DIETARY_SUPPLEMENT: Placebo food supplement capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Advanced Hematologic Cancer
Status: COMPLETED
Conditions: Graft Versus Host Disease|Leukemia|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: DRUG: busulfan|DRUG: melphalan|DRUG: methotrexate|DRUG: tacrolimus|PROCEDURE: allogeneic bone marrow transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Canadian e-Platform to Promote Behavioral Self-Management in Chronic Heart Failure: CHF-CePPORT
Status: COMPLETED
Conditions: Heart Failure
Interventions: BEHAVIORAL: eCounseling + Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: App-supported Vestibular Rehabilitation (RCT)
Status: RECRUITING
Conditions: Vestibular Disorder|Vestibular Diseases|Vestibular Abnormality
Interventions: DEVICE: Vestibular rehabilitation phone application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Effectiveness of Efgartigimod in Patients With Primary Sjögren's Syndrome (pSS)
Status: COMPLETED
Conditions: Primary Sjögren's Syndrome
Interventions: BIOLOGICAL: Efgartigimod|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pharmacokinetic, Safety, Immunogenicity and Efficacy of CMAB819 and Nivolumab in R/M HNSCC
Status: TERMINATED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: CMAB819|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Posterior Subtenon Versus Intravitreal Injection of Triamcinolone Acetonide for Treatment of Uveitic Cystoid Macular Edema
Status: WITHDRAWN
Conditions: Uveitis|Cystoid Macular Edema
Interventions: DRUG: Triamcinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Immune Tolerance and Capacity for Wound Healing of Patients With Recessive Dystrophic Epidermolysis Bullosa (RDEB)
Status: UNKNOWN
Conditions: Recessive Dystrophic Epidermolysis Bullosa
Interventions: OTHER: Blood collection|OTHER: Skin biopsies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PATH to Health: An Exploration of Digital Behavioral Weight Loss Approaches
Status: COMPLETED
Conditions: Overweight|Obesity|Overweight and Obesity
Interventions: BEHAVIORAL: App|BEHAVIORAL: Fully Automated Kick-Off|BEHAVIORAL: Human-Enhanced Kick-Off|BEHAVIORAL: Check-In|BEHAVIORAL: Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Assessment of Three Non Pharmacological Therapies in Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: BEHAVIORAL: Standard intervention protocol|BEHAVIORAL: Standard intervention protocol + Cognitive training therapy|BEHAVIORAL: Standard intervention protocol + Reminiscence therapy|BEHAVIORAL: Standard intervention protocol + "Made-to-measure" program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality for Pain Control During Extracorporeal Shock Wave Lithotripsy: a Prospective, Comparative, Randomized Study at a Single Institution
Status: COMPLETED
Conditions: Stone, Kidney|Stone Ureter
Interventions: DEVICE: Oncomfort virtual reality monitor (Oncomfort SA, Wavre, Belgium)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylaxis of CHB Patients With Malignant Tumor Receiving Chemotherapy
Status: COMPLETED
Conditions: Hepatitis B, Chronic|Tumor
Interventions: OTHER: TDF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Pilot Study of Immunotherapy Including Haploidentical NK Cell Infusion Following CD133+ Positively-Selected Autologous Hematopoietic Stem Cells in Children With High Risk Solid Tumors or Lymphomas
Status: COMPLETED
Conditions: Neuroblastoma|Lymphoma|High-risk Tumor
Interventions: BIOLOGICAL: CD133+ selected autologous stem cell infusion|BIOLOGICAL: IL-2|BIOLOGICAL: hu14.18K322A|DRUG: Busulfan|DRUG: Melphalan|BIOLOGICAL: GM-CSF|DRUG: Bendamustine|DRUG: Etoposide|DRUG: Cytarabine|DRUG: Carboplatin|DEVICE: Haploidentical natural killer cell infusion|BIOLOGICAL: G-CSF|DRUG: Etoposide phosphate|DEVICE: CliniMACS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Music vs Midazolam During Preop Nerve Block Placement - Part 2 Study On Anxiolytic Options Before Peripheral Nerve Blocks
Status: RECRUITING
Conditions: Peripheral Nerve Block|Anxiety|Preoperative Anxiety
Interventions: OTHER: Music|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Effect of Reinforced Family Assistance on the Quality of Bowel Preparation for Colonoscopy
Status: UNKNOWN
Conditions: Bowel Preparation
Interventions: BEHAVIORAL: reinforced family member education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Sounds of Compassion: Testing How Specific Elements of Meditation Change Daily Life
Status: COMPLETED
Conditions: Immune System Processes|Inflammatory Activation and Modulation|ANS Function
Interventions: BEHAVIORAL: Cognitive-Based Compassion Training|BEHAVIORAL: Adult Health Education Curriculum|BEHAVIORAL: Mindful Attention Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Ischemic Preconditioning on Postoperative Pain After Total Knee Arthroplasty, a Randomized, Controlled Trial
Status: COMPLETED
Conditions: Total Knee Arthroplasty|Ischemic Preconditioning|Postoperative Pain
Interventions: PROCEDURE: Ischemic Preconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Family-centered Support Program for Caregivers of Stroke Survivors
Status: COMPLETED
Conditions: Stroke|Caregiver Burden
Interventions: OTHER: Family-centered support program for caregivers of stroke survivors
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Ospemifene in the Treatment of Moderate to Severe Vaginal Dryness and Vaginal Pain Associated With Sexual Activity
Status: COMPLETED
Conditions: Atrophy|Vaginal Diseases
Interventions: DRUG: Ospemifene 60 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-escalating Safety Study in Subjects on Stable Statin Therapy
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: ISIS 301012 or Placebo|DRUG: ISIS 301012 or Placebo|DRUG: ISIS 301012 or Placebo|DRUG: ISIS 301012 or Placebo|DRUG: ISIS 301012 or Placebo|DRUG: ISIS 301012 or Placebo|DRUG: ISIS 301012 or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy and Radioembolisation for Metastatic Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Durvalumab|DRUG: Tremelimumab|RADIATION: Yttrium-90 radioembolisation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Executive Function/Metacognitive Training for At-Risk Preschoolers
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: Executive Training of Attention and Metacognition (ETAM)|BEHAVIORAL: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: RECORD: Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Rosiglitazone|DRUG: Sulfonylurea|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PA32540 or Enteric Coated Aspirin 325 mg in Subjects Who Are at Risk for Developing Aspirin-Associated Ulcers
Status: COMPLETED
Conditions: Gastric Ulcer
Interventions: DRUG: PA32540|DRUG: EC-Aspirin 325 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AmplifEYE Colonoscopy vs Standard Colonoscopy
Status: COMPLETED
Conditions: Colon Polyp|Adenoma Colon|Serrated Polyp|Colonic Neoplasms
Interventions: DEVICE: AmplifEYE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Surgical Resection Plus Chemotherapy Versus Chemotherapy Alone in Oligometastatic Stage IV Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Adenocarcinoma
Interventions: DRUG: Preoperative Chemotherapy|PROCEDURE: Surgery|DRUG: Postoperative chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Collagen Mesh for Prevention of Ventral Hernia After Surgery for Advanced Pelvic Cancer
Status: COMPLETED
Conditions: Incisional Hernia|Pelvic Cancer
Interventions: PROCEDURE: Mesh repair|PROCEDURE: Conventional facial closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Progressive Relaxation Exercises,Breastfeeding
Status: RECRUITING
Conditions: Progressive Relaxation Exercises
Interventions: OTHER: progressive relaxation exercise|OTHER: relaxation background music|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Immunogenocity Study of GSK Biologicals' Pandemic Influenza (H1N1) Candidate Vaccine in Japanese Children
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: GSK Biologicals' Pandemic influenza (H1N1) candidate vaccine (GSK2340274A)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Efficacy and Safety Study of Vedolizumab Intravenous (IV) Compared to Adalimumab Subcutaneous (SC) in Participants With Ulcerative Colitis
Status: COMPLETED
Conditions: Colitis, Ulcerative
Interventions: DRUG: Vedolizumab|DRUG: Adalimumab placebo|DRUG: Adalimumab|DRUG: Vedolizumab placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Three-level Model of DBT-informed Care for Youth With and/or at Familial Risk for Bipolar Disorder (DB3)
Status: RECRUITING
Conditions: Bipolar Disorder
Interventions: BEHAVIORAL: Enhanced Care|BEHAVIORAL: DBT Skills Training|BEHAVIORAL: Dialectical Behavior Therapy Full Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DLCS for Predicting Neoadjuvant Chemotherapy Response
Status: RECRUITING
Conditions: Gastric Cancer|CT Images|Deep Learning|Neoadjuvant Chemotherapy|Tumor Regression Grade
Interventions: OTHER: develop and visualized a radio-clinical signatures from pretreatment oversampled CT images
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Radiotherapy for BCG-unresponsive Non-muscle-invasive Carcinoma in Situ (CIS) Bladder Cancer
Status: NOT_YET_RECRUITING
Conditions: Bladder Cancer
Interventions: RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy and Safety of Intranasal Administration of 100, 200, and 400 μg of Fluticasone Propionate Twice a Day (BID) Using a Novel Bi Directional Device in Subjects With Bilateral Nasal Polyposis Followed by an 8-Week Open-Label Extension Phase to Assess Safety
Status: COMPLETED
Conditions: Bilateral Nasal Polyposis
Interventions: DRUG: Fluticasone Propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of RNA From the Liver Tissue Obtained in Patients With Chronic Hepatitis C (0000-123)
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: PROCEDURE: Comparator: Fine needle aspiration biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of REL-1017 (d-Methadone)
Status: COMPLETED
Conditions: Neuropathic Pain
Interventions: DRUG: REL-1017|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Air Versus Gas Tamponade in Primary Retinal Detachment
Status: UNKNOWN
Conditions: Retinal Detachment|Proliferative Vitreoretinopathy
Interventions: PROCEDURE: Pars plana vitrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness Verification of a Smartphone-based System for Assessment and Health Care on Myofascial Pain Syndrome
Status: NOT_YET_RECRUITING
Conditions: Myofascial Pain Syndrome
Interventions: DEVICE: App healthcare|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Mavrilimumab (KPL-301) in Participants Hospitalized With Severe Corona Virus Disease 2019 (COVID-19) Pneumonia and Hyper-inflammation
Status: COMPLETED
Conditions: COVID
Interventions: DRUG: mavrilimumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Levosimendan in Patients Eligible for Aortic Valve Replacement With Left Ventricular Hypertrophy
Status: TERMINATED
Conditions: Diastolic Dysfunction|Left Ventricular Hypertrophy
Interventions: DRUG: levosimendan|DRUG: placebo drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Anlotinib as the Maintenance Therapy for Extensive-stage Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Extensive-stage Small Cell Lung Cancer
Interventions: DRUG: Anlotinib Hydrochloride; etoposide and cisplatin|DRUG: etoposide and cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of Treatment of Articular Cartilage Lesions With CartiLife®
Status: COMPLETED
Conditions: Articular Cartilage Lesion of the Knee
Interventions: DRUG: CartiLife®|PROCEDURE: Microfracture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tailored Bowel Preparation According to Bristol Stool Form Scale
Status: COMPLETED
Conditions: Bowel Cleansing Quality
Interventions: DRUG: Standard Bowel Prep (2L PEG-ELP)|DRUG: 2L PEG-ELP and 10mg bisacodyl|DRUG: Standard Bowel Prep (2L PEG-ELP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Peripheral EBUS With ROSE vs no ROSE; Slim Bronchoscope Without Guide Sheath vs Standard Bronchoscope With Guide Sheath
Status: ACTIVE_NOT_RECRUITING
Conditions: Peripheral Pulmonary Lesions|Lung Cancer
Interventions: PROCEDURE: Rapid on-site evaluation (ROSE)|PROCEDURE: Slim bronchoscope without a guide sheath|PROCEDURE: Standard pEBUS with guide sheath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Therapy With Docetaxel and ZD1839 for Patients Who Have Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: ZD1839 in combination with docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Description of the Immune Deficiency in Patients With Untreated Chronic Lymphocytic Leukemia and Search for Predictive Factors of Infectious Risk
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: Blood sampling & Chest CT without injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: ASPirin Intervention for the REDuction of Colorectal Cancer Risk
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: Aspirin|DRUG: Placebo for Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Novel Nutraceutical to Combat Post-Lyme Disease Syndrome
Status: COMPLETED
Conditions: Post-Lyme Disease Syndrome (PLDS)
Interventions: DIETARY_SUPPLEMENT: RLP|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Home Base Whole-body Vibration in Osteoarthritis. (VIBE-Rx2)
Status: NOT_YET_RECRUITING
Conditions: Whole Body Vibration|Osteo Arthritis Knee
Interventions: DEVICE: Sub Acute Whole Body Vibration Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinicianless Training in Autism Treatment: An Adaptive Online Parent Education Program
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Parents
Interventions: BEHAVIORAL: Smartphone-App Parent Training in Pivotal Response Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation of SNK-396 in Participants With Elevated Low-Density Lipoprotein Cholesterol
Status: COMPLETED
Conditions: Elevated Low-Density Lipoprotein Cholesterol
Interventions: DRUG: SNK-396 - SAD cohort|DRUG: SNK-396 - MAD Cohort
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Albuvirtide in Combination With 3BNC117 in Patients With Multi-Drug Resistant (MDR) HIV-1 Infection
Status: UNKNOWN
Conditions: HIV/AIDS
Interventions: DRUG: Albuvirtide|DRUG: 3BNC117 Antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immuno-bridging and Broadening Study of a Whole, Inactivated COVID-19 Vaccine BBV152 in Healthy Adults
Status: RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: BBV152
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Yoga vs Stretching in Veterans With Chronic Lower Back Pain: Does Mindfulness Matter?
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: OTHER: Yoga (stretching plus mindfulness)|OTHER: Stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Influence of Habitual Protein Intake on AA Tracer Oxidation
Status: COMPLETED
Conditions: Protein/Amino Acid Metabolism|Indicator Amino Acid Oxidation Method
Interventions: OTHER: Dietary protein intake reduction|OTHER: Three day Controlled Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Inter-fascial Plane Between the SArtorius Muscle and FEmoral Artery (ISAFE)
Status: COMPLETED
Conditions: Anesthesia, Conduction|Arthroplasty, Replacement, Knee
Interventions: OTHER: ISAFE technique for adductor canal catheter insertion|OTHER: Conventional technique for adductor canal catheter insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ATI-1777 in Adult Patients With Moderate or Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: ATI-1777|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paroxetine/Bupropion in Suicide Attempters/Ideators With Major Depression
Status: TERMINATED
Conditions: Depression
Interventions: DRUG: Paroxetine|DRUG: Bupropion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Metformin Plus Biphasic Insulin Aspart 30 in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: metformin|DRUG: biphasic insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Safety Study of the Intravenous Administration of Thymosin Beta in Healthy Volunteers
Status: WITHDRAWN
Conditions: Myocardial Infarction|Myocardial Ischemia
Interventions: DRUG: thymosin beta 4|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Acute Human Intervention With Flavonoid to Investigate Absorption, Metabolism and Excretion
Status: UNKNOWN
Conditions: Pharmacokinetics of Flavonoids in Humans
Interventions: DIETARY_SUPPLEMENT: Flavonoids
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety, Efficacy and Dose Titration of Sodium Oligo-mannurarate Capsule on Mild to Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease|Cognitive Impairment
Interventions: DRUG: Sodium oligo-mannurarate 600mg|DRUG: Sodium oligo-mannurarate 900mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Mechano-Analgesia and Cold Application on Ecchymosis, Pain and Satisfaction at Subcutaneous Heparin Injection
Status: COMPLETED
Conditions: Injection Site Reaction|Injection Site Bruising
Interventions: DEVICE: ShotBlocker|DEVICE: Ice pack
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preventing Surgical Site Infection by Using Prophylactic Occlusive Ionic Silver-containing Dressing
Status: UNKNOWN
Conditions: Surgical Site Infection
Interventions: OTHER: Prophylactic advance wound dressing|OTHER: Prophylactic conventional wound dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Healthcare Provider Human Papillomavirus Education and Professional Skills Intervention
Status: RECRUITING
Conditions: Health Personnel Attitude|Health Knowledge, Attitudes, Practice
Interventions: BEHAVIORAL: Tailored HPV Education and Professional Skills Intervention Group|BEHAVIORAL: General HPV Education and Communication Skills Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Unified Intervention for Young Gay and Bisexual Men's Minority Stress, Mental Health, and HIV Risk
Status: COMPLETED
Conditions: HIV|Acquired Immunodeficiency Syndrome
Interventions: BEHAVIORAL: ESTEEM|BEHAVIORAL: CMHT|BEHAVIORAL: VCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: RCT: Effectiveness of a Microscope During Dental Root Apical Surgery
Status: UNKNOWN
Conditions: Effectiveness of Microscope During Apical Surgery in Endodontic Treated Teeth.
Interventions: PROCEDURE: Surgical treatment with microscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study With Healthy Japanese and Non-Asian Participants With BMS-986231
Status: COMPLETED
Conditions: Heart Decompensation, Acute
Interventions: DRUG: BMS-986231|DRUG: BMS-986231 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of High-dose Target-controlled Naloxone Infusion on Pain and Hyperalgesia During a Burn Injury
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Naloxone|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: IV Lidocaine Analgesia in Pediatric Scoliosis Surgery
Status: COMPLETED
Conditions: Scoliosis; Adolescence|Anesthesia Recovery Period
Interventions: DRUG: Lidocaine|DRUG: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness and Safety of Intradermal Tranexamic Acid Injection as An Adjunctive Treatment for Melasma in Skin Type IV - V
Status: COMPLETED
Conditions: Melasma
Interventions: DRUG: Tranexamic acid injection|DRUG: Injection Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Premedication With Oral Midazolam in Patients Undergoing Rigid Cystoscopy: A Randomized, Double-blind, Placebo-controlled Trial
Status: UNKNOWN
Conditions: Cystoscopy
Interventions: DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Study of 6b11-OCIK Injection Treatment in Patients With Recurrent Drug-resistant Ovarian Cancer
Status: UNKNOWN
Conditions: Recurrent Ovarian Carcinoma|Platinum-resistant Ovarian Cancer
Interventions: DRUG: 6B11-OCIK Injection|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Peginterferon Alfa-2a in Combination With Ribavirin in Patients With Chronic Hepatitis C
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: peginterferon alfa-2a|DRUG: rivavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Cardiac Rehabilitation With Motivational Interview for Acute Myocardial Infarction
Status: RECRUITING
Conditions: Myocardial Infarction, Acute
Interventions: BEHAVIORAL: Motivational interview|BEHAVIORAL: Active Comparator: Standard care group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the XP1100RF Therapy on Thighs Circumference Reduction
Status: COMPLETED
Conditions: Thighs Circumferential Reduction|Subcutaneous Fat Cell Disruption
Interventions: DEVICE: XP1100RF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VIBRANT: VIB4920 for Active Lupus Nephritis
Status: RECRUITING
Conditions: Lupus Nephritis
Interventions: DRUG: VIB4920|DRUG: Placebo for VIB4920
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of the Efficacy of CD19-CAR-DNT Cells in the Treatment of Relapsed/Refractory B-cell NHL
Status: RECRUITING
Conditions: B-cell Non-Hodgkin's Lymphoma
Interventions: BIOLOGICAL: CD19-CAR-DNT cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Compare The Effects Of The Infusion Of A Sepsis Drug Between Healthy Adults And Adults With Damaged Livers
Status: COMPLETED
Conditions: Sepsis
Interventions: DRUG: Intravenous GR270773 - Phospholipid emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Letermovir Versus Valganciclovir to Prevent Human Cytomegalovirus Disease in Kidney Transplant Recipients (MK-8228-002)
Status: COMPLETED
Conditions: CMV Disease
Interventions: DRUG: Letermovir|DRUG: Valganciclovir|DRUG: Acyclovir (ACV)|DRUG: Placebo to ACV|DRUG: Placebo to LET|DRUG: Placebo to VGCV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Efficacy of Different Methods of Tobacco Cessation Interventions Among BEST Employees in Mumbai
Status: UNKNOWN
Conditions: Compliance|Tobacco Use Cessation
Interventions: OTHER: Tobacco users: Self Help|BEHAVIORAL: Tobacco users:Telephonic counseling|BEHAVIORAL: Tobacco users:Behavioural therapy Only|OTHER: Tobacco users:Pharmacologic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Community-based Education, Navigation, and Support Intervention for Military Veterans
Status: RECRUITING
Conditions: Overdose|Opioid Use Disorder|HIV Infections
Interventions: BEHAVIORAL: Overdose Education and Naloxone Distribution|BEHAVIORAL: Advanced Education in Safer Substance Use, Treatment, and Self-Care|BEHAVIORAL: Social Service and Health Navigation|BEHAVIORAL: Peer Social Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Diaphragmatic Exercises and Fascial Release Techniques on the Treatment of Lower Extremity Lymphedema
Status: UNKNOWN
Conditions: Lower Extremity Lymphedema
Interventions: OTHER: Complex Decongestive Physiotherapy|OTHER: Multidimensional Diaphragmatic Breathing Exercises|OTHER: Facial Release Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Assessing Metabolism, Excretion and Pharmacokinetics of a Poly (ADP-Ribose) Polymerase (PARP) Inhibitor in Patients With Solid Metastatic Tumours
Status: COMPLETED
Conditions: Neoplasm Metastasis
Interventions: DRUG: AZD2281
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Trastuzumab Emtansine (Trastuzumab-MCC-DM1) Administered Intravenously to Patients With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Trastuzumab emtansine [Kadcyla]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of MACS and Time-lapse Technology in Good-prognosis Patients
Status: TERMINATED
Conditions: MACS Technique Efficacy
Interventions: OTHER: MACS|OTHER: NO MACS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Bortezomib, Ifosfamide, Carboplatin, and Etoposide, With or Without Rituximab, in Treating Patients With Relapsed or Refractory AIDS-Related Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: bortezomib|DRUG: carboplatin|DRUG: dexamethasone|DRUG: etoposide|DRUG: ifosfamide|GENETIC: polymerase chain reaction|GENETIC: western blotting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telmisartan80/HCTZ25 Versus Telmisartan80/HCTZ12.5 in Hypertension Not Responding to Telmisartan80/HCTZ12.5
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Fixed dose combination telmisartan 80 mg + HCTZ 25 mg|DRUG: Fixed dose combination telmisartan 80 mg + HCTZ 12.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Amifostine Followed by High Dose Chemotherapy in Treating Patients With Hematologic Cancer or Solid Tumors
Status: COMPLETED
Conditions: Breast Cancer|Drug/Agent Toxicity by Tissue/Organ|Lung Cancer|Lymphoma|Ovarian Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: sargramostim|DRUG: amifostine trihydrate|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Practice-nurse Addressed Intervention to Improve Type 2 Diabetes Care
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Training course for practice nurses in autonomy support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Muscadine Grape Skin Extract in Treating Patients With Malignancy That Is Metastatic or Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Advanced Malignant Neoplasm|Metastatic Malignant Neoplasm|Unresectable Malignant Neoplasm
Interventions: DIAGNOSTIC_TEST: Laboratory Biomarker Analysis|DRUG: Muscadine Grape Skin Extract|PROCEDURE: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PROject - Supportive and Palliative Care and INnOvation - Antwerp (Pro-Spinoza)
Status: COMPLETED
Conditions: Palliative Care|Primary Health Care
Interventions: OTHER: Care Pathway for Primary Palliative Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Treatment of Non-high-risk Acute Promyelocytic Leukemia (APL) With Realgar-Indigo Naturalis Formula (RIF)
Status: UNKNOWN
Conditions: Acute Promyelocytic Leukemia
Interventions: DRUG: Realgar-Indigo naturalis formula|DRUG: all-trans retinoic acid|DRUG: Arsenic trioxide|DRUG: Hydroxyurea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Previously Implanted Pudendal Nerve Stimulation
Status: COMPLETED
Conditions: Urinary Retention|Underactive Bladder
Interventions: DEVICE: Medtronic Interstim II Model 3058 Neurostimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pilot First In Man Study of EXCEL-Ⅱto Treat the Patients With de Novo Coronary Artery Lesions
Status: COMPLETED
Conditions: Ischemia|Coronary Artery Disease
Interventions: DEVICE: EXCEL-Ⅱ
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic Colorectal Cancer That Progressed During First-Line Therapy
Status: TERMINATED
Conditions: Recurrent Colon Cancer|Recurrent Rectal Cancer|Stage IVA Colon Cancer|Stage IVA Rectal Cancer|Stage IVB Colon Cancer|Stage IVB Rectal Cancer
Interventions: DRUG: irinotecan hydrochloride|DRUG: leucovorin calcium|DRUG: fluorouracil|BIOLOGICAL: cetuximab|BIOLOGICAL: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Marizomib With Temozolomide and Radiotherapy in Patients With Newly Diagnosed Brain Cancer
Status: COMPLETED
Conditions: Glioblastoma|Malignant Glioma
Interventions: DRUG: MRZ|DRUG: TMZ|RADIATION: RT|DEVICE: Optune
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Multi-Center Study of the Pimecrolimus-Eluting and Pimecrolimus/Paclitaxel-Eluting Coronary Stent Systems (GENESIS)
Status: COMPLETED
Conditions: Coronary Disease
Interventions: DEVICE: Corio™ Pimecrolimus-Eluting Coronary Stent System|DEVICE: SymBio™ Pimecrolimus/Paclitaxel-Eluting Coronary Stent System|DEVICE: Costar ™ Paclitaxel-Eluting Coronary Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cumulative and Booster Effects of Multisession Prefrontal tDCS in Adolescents With ASD
Status: RECRUITING
Conditions: Transcranial Direct Current Stimulation|Autistic Spectrum Disorder|Electroencephalography
Interventions: DEVICE: Active-tDCS|DEVICE: Sham-tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Growth Hormone in MPS I, II, and VI
Status: TERMINATED
Conditions: Mucopolysaccharidosis I|Mucopolysaccharidosis II|Mucopolysaccharidosis VI
Interventions: DRUG: Somatropin (DNA origin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adrenal Suppression and Pharmacokinetics of Topicort® Spray, 0.25% in Pediatric Patients With Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Topicort® (desoximetasone) Topical Spray, 0.25%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benson Relaxation Technique on Perceived Stress and Pain Among Hemodialysis Patients
Status: UNKNOWN
Conditions: Relaxation
Interventions: BEHAVIORAL: Benson Relaxation Technique|OTHER: Nutrition Package Session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Photodisinfection for the Decolonization of Staphylococcus Aureus in Hemodialysis Patients
Status: WITHDRAWN
Conditions: Staphylococcus Aureus Infection|MSSA Colonization
Interventions: DEVICE: photodynamic therapy (Ondine: MRSAid™)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evidence of Haloperidol Absorption After Topical Administration
Status: WITHDRAWN
Conditions: Nausea|Vomiting
Interventions: DRUG: Haloperidol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ergocalciferol on Iron Metabolism in Individuals With Chronic Kidney Disease
Status: WITHDRAWN
Conditions: CKD|Chronic Kidney Diseases|Hepcidin|Ergocalciferol|Vitamin D|Iron-deficiency|Anemia
Interventions: DRUG: Ergocalciferol 50000 UNT|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modulated Electro-Hyperthermia Plus Chemo-radiation for Locally Advanced Cervical Cancer Patients in South Africa
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: DEVICE: Modulated electro-hyperthermia|RADIATION: External beam radiation|DRUG: Cisplatin|RADIATION: Brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT