pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Anti-r-HuEpo Associated Pure Red Cell Aplasia (PRCA) Treatment
Status: TERMINATED
Conditions: Anti-r-HuEpo Associated PRCA Subjects
Interventions: DRUG: Cyclosporine combine with mycophenolate mofetil|DRUG: Cyclophosphamide + pred
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Magnesium Supplement in Early Pregnancy After ICSI
Status: UNKNOWN
Conditions: ICSI
Interventions: DRUG: Magnesium Oxide|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does BIO-RSA Provides Superior Clinical Outcome Compared to Conventional RSA?
Status: RECRUITING
Conditions: Arthroplasty, Replacement, Shoulder|Shoulder Osteoarthritis
Interventions: PROCEDURE: BIO-RSA|PROCEDURE: RSA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Epoetin Alfa in Treating Anemia in Patients With Solid Tumors
Status: COMPLETED
Conditions: Anemia|Leukemia|Lymphoma|Lymphoproliferative Disorder|Multiple Myeloma and Plasma Cell Neoplasm|Precancerous Condition|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Epinephrine, Dexamethasone and Hypertonic Saline in Bronchiolitis
Status: UNKNOWN
Conditions: Bronchiolitis
Interventions: DRUG: Hypertonic Saline 3%|DRUG: Epinephrine and Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Dose Tolerance, Pharmacokinetics, Pharmacodynamics of CPX-POM in Patients With Newly Diagnosed or Recurrent Bladder Tumors
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: CPX-POM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Balance in TBI Using Virtual Reality
Status: UNKNOWN
Conditions: Traumatic Brain Injury
Interventions: OTHER: Standard of Care Balance Intervention|OTHER: Mystic Isle Balance Intervention|OTHER: Mystic Isle Balance Intervention with Dual Task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct-current Stimulation (tDCS) in Treatment Refractory Auditory Hallucinations
Status: COMPLETED
Conditions: Auditory Hallucination|Schizophrenia
Interventions: DEVICE: Transcranial direct-current stimulation (tDCS)|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PCT and Clinical Algorithm for Determination of Duration of Antibiotics
Status: COMPLETED
Conditions: Infection
Interventions: OTHER: PCT and clinical algorithm for stopping abx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rosiglitazone Versus a Sulfonylurea On Progression Of Atherosclerosis In Patients With Heart Disease And Type 2 Diabetes
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DRUG: Glipizide|DRUG: rosiglitazone maleate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Delayed Cold-Stored Platelets -PLTS-1
Status: RECRUITING
Conditions: Platelets|Bleeding|Cardiopulmonary Bypass|Cardiac Surgery
Interventions: BIOLOGICAL: Delayed Cold-Stored Buffy Coat Platelets|BIOLOGICAL: Room Temperature Buffy Coat Platelets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxytocin, Emotions and Mirror Neurons
Status: COMPLETED
Conditions: Social Cognition|Expressed Emotion
Interventions: DRUG: Oxytocin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BI 653048 BS H3PO4 Capsule Multiple Rising Doses in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 653048 BS H3PO4|DRUG: Prednisolone low dose|DRUG: Prednisolone high dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of a Patient Warming System Using a Forced-air, Non-compressible Under-body Mattress Versus a Regular Forced-air Underbody Mattress System During Pediatric Cardiac Catheterization
Status: WITHDRAWN
Conditions: Hypothermia
Interventions: DEVICE: Forced air warming compressible|DEVICE: Forced air non-compressible
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: High-Dose Gleevec Alone or in Combination With Peg-Intron and GM-CSF in Early Phase Chronic Myelogenous Leukemia (CML)
Status: COMPLETED
Conditions: Leukemia, Myeloid, Chronic
Interventions: DRUG: Gleevec|DRUG: Peg-alpha interferon (Peg-Intron)|DRUG: Sargramostim (GM-CSF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Circulating Tumor DNA to Guide Changes in Standard of Care Chemotherapy
Status: SUSPENDED
Conditions: Metastatic HER2-Negative Breast Carcinoma|Metastatic Triple-Negative Breast Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Biospecimen Collection|BIOLOGICAL: Sacituzumab Govitecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mitral Valve in Hypertrophic Cardiomyopathy
Status: COMPLETED
Conditions: Hypertrophic Obstructive Cardiomyopathy
Interventions: PROCEDURE: isolated septal myectomy|PROCEDURE: septal myectomy + edge-to-edge mitral valve repair|PROCEDURE: septal myectomy + posterior leaflet sliding plasty|PROCEDURE: septal myectomy + secondary chordae transection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-frequency Electrical Stimulation of Acupuncture Points
Status: COMPLETED
Conditions: Stroke Sequelae
Interventions: DRUG: low-frequency acupoint electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allo Transplantation With Mylotarg, Fludarabine and Melphalan for AML, CML and MDS
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Myelodysplastic Syndrome|Chronic Lymphocytic Leukemia
Interventions: DRUG: Mylotarg|DRUG: Fludarabine|DRUG: Melphalan|DRUG: Anti-thymocyte globulin|PROCEDURE: Stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects Of Adjunctive Photodynamic Therapy To Non-Surgical Periodontal Treatment In Patients With Generalized Aggressive Periodontitis
Status: COMPLETED
Conditions: Generalized Aggressive Periodontitis
Interventions: DEVICE: Ultrasonic|DEVICE: Hand Instruments|DEVICE: LED Source
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Intravenous Dose Study Of PF-04360365 In Japanese Patients With Mild To Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: BIOLOGICAL: PF-04360365 8.5 mg/kg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Assessment of Residual Spherical Aberration, Postoperative Total High Order Aberrations, and Functional Vision Correlation Following Intraocular Lens (IOL) Implantation
Status: COMPLETED
Conditions: Cataracts
Interventions: DEVICE: Acrysof IQ (SN60WF) IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Quantitative Imaging Biomarkers of Treatment Response in Osteosarcoma and Ewing Sarcoma
Status: TERMINATED
Conditions: Osteosarcoma|Paget's Disease|Ewing Sarcoma
Interventions: OTHER: DCE-MRI, DW-MRI, MT-MRI, and CEST-MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Decisional Capacity and Informed Consent in Fragile X Syndrome
Status: COMPLETED
Conditions: Fragile X Syndrome (FXS)
Interventions: OTHER: Paper and Pencil Informed Consent|OTHER: Digital Informed Consent Tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Ultrahypofractionation and Normal Tissue Toxicity
Status: RECRUITING
Conditions: Breast Cancer|Breast Cancer Female|Breast Cancer Stage II|Breast Cancer Stage III|Myocardial Fibrosis
Interventions: RADIATION: Accelerated Proton Beam Radiation Therapy (PBT)|RADIATION: Accelerated Photon Radiation Therapy (XRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Artesunate & Curcumin in Crohn's Disease
Status: RECRUITING
Conditions: Crohn's Disease
Interventions: DRUG: Artesunate|DRUG: Curcumin|DRUG: Placebo A|DRUG: Placebo C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Donepezil and the Risk of Falls in Seniors With Cognitive Impairment
Status: COMPLETED
Conditions: Falls|Gait|Balance|Mild Cognitive Impairment (MCI)
Interventions: DRUG: Donepezil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Micronutrients as Adjunctive Treatment for Bipolar Disorder
Status: UNKNOWN
Conditions: Bipolar Disorder
Interventions: DIETARY_SUPPLEMENT: Micronutrient & Fish oil|DIETARY_SUPPLEMENT: Olive oil & Safflower oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Role of Antisecretory Factor in Curative Radiochemotherapy for Anal Carcinoma
Status: UNKNOWN
Conditions: Anal Cancer
Interventions: DIETARY_SUPPLEMENT: Salovum and SPC-flakes or corresponding placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Furlow Palatoplasty With Tensor Tenopexy
Status: COMPLETED
Conditions: Otitis Media|Cleft Palate
Interventions: PROCEDURE: palatoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of 24 or 48 Weeks of Peginterferon Alfa-2a Plus Ribavirin for HCV Genotype 1-infected Patients
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Pegylated interferon alfa-2a plus ribavirin|DRUG: Pegylated interferon alfa-2a plus ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Live Combined Bifidobacterium and Lactobacillus on Glycemic Control and Other Outcomes in Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus|Probiotics
Interventions: DRUG: live combined Bifidobacterium and Lactobacillus Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Inspiratory Muscle Trainer and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) COVID-19 Persistent Symptoms
Status: COMPLETED
Conditions: Covid19|Hypertension|Corona Persistent Symptoms
Interventions: DEVICE: Inspiratory muscle trainer|OTHER: diaphragmatic release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Mandibular Dentures Immediately Loaded on Implants or Mini-implants
Status: COMPLETED
Conditions: Problem With Dentures
Interventions: OTHER: implant-supported mandibular overdenture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Trial of Bevacizumab Treatment for Severe Retinopathy of Prematurity
Status: COMPLETED
Conditions: Retinopathy of Prematurity
Interventions: DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Find the Safe Dose for BI 891065 Alone and in Combination With BI 754091 in Patients With Incurable Tumours or Tumours That Have Spread
Status: TERMINATED
Conditions: Neoplasms|Neoplasm Metastasis|Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: BI 891065|DRUG: BI 754091
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CaMaPi for Adolescents/Young People With a History of Self-harm and Suicidal Ideation in Jos, Nigeria
Status: NOT_YET_RECRUITING
Conditions: Self-harm|Suicidal Ideation
Interventions: BEHAVIORAL: CaMaPi|OTHER: TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Recombinant Versus Highly Purified FSH in Polycystic Ovary Syndrome (PCOS)
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Gonal-F, Fostimon|DRUG: Gonal-F, Fostimon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Potassium Citrate on Bone Metabolism
Status: COMPLETED
Conditions: Bone Diseases, Metabolic|Osteoporosis, Postmenopausal
Interventions: DRUG: potassium citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Subcutaneous Blinatumomab Administration in Acute Lymphoblastic Leukemia (ALL) Patients
Status: RECRUITING
Conditions: B Cell Precursor Acute Lymphoblastic Leukemia
Interventions: DRUG: Blinatumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Daclizumab for the Prevention of Allograft Rejection in Pediatric Heart Transplant Patients
Status: TERMINATED
Conditions: Cardiac Transplantation
Interventions: DRUG: Daclizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Value of Combined Critical Care Ultrasound and PAC Monitor Oriented Therapy Protocol to Patients of ARDS With ACP
Status: UNKNOWN
Conditions: Respiratory Distress Syndrome, Adult|Ventricular Dysfunction, Right
Interventions: DEVICE: PAC catheter and critical care ultrasound examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Left Atrial Arrhythmia Substrate Identification After Confirmed durABLE Pulmonary Vein Isolation
Status: UNKNOWN
Conditions: Atrial Fibrillation|Persistent Atrial Fibrillation
Interventions: PROCEDURE: Cryoballoon pulmonary vein isolation|PROCEDURE: Radiofrequency pulmonary vein isolation|PROCEDURE: Repeat electrophysiological study|PROCEDURE: Left atrial posterior wall isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shorter Course Tacro After NMA, Related Donor PBSCT With High-dose Posttransplant Cy for Hard-to-Engraft Malignancies
Status: COMPLETED
Conditions: Myelodysplastic Syndrome|Chronic Myelomonocytic Leukemia|Small Lymphocytic Lymphoma|Chronic Lymphocytic Leukemia|Prolymphocytic Leukemia|Chronic Myeloid Leukemia|Chronic Myeloproliferative Disorders|Multiple Myeloma|Plasma Cell Neoplasm|Plasma Cell Dyscrasia|Myelofibrosis|Polycythemia Vera|Essential Thrombocythemia|Plasma Cell Leukemia
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide|RADIATION: Total body irradiation|DRUG: Tacrolimus|DRUG: Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Study of the Efficacy of Cerezyme in Testing Skeletal Disease in Patients With Type I Gaucher Disease.
Status: COMPLETED
Conditions: Gaucher Disease Type I|Cerebroside Lipidosis Syndrome|Clucocerebrosidase Deficiency Disease|Glucosylceramide Beta-Glucosidase Deficiency Disease|Gaucher Disease, Non-Neuronopathic Form
Interventions: DRUG: Cerezyme (imiglucerase for injection)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Eculizumab in Japanese Patients With Atypical Hemolytic Uremic Syndrome (aHUS)
Status: COMPLETED
Conditions: Atypical Hemolytic Uremic Syndrome (aHUS)
Interventions: DRUG: Eculizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Efficacy and Pharmacokinetics Study of a Recombinant Fusion Protein Linking Coagulation Factor IX With Albumin (rIX-FP) in Children With Hemophilia B
Status: COMPLETED
Conditions: Hemophilia B
Interventions: BIOLOGICAL: rIX-FP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)
Status: RECRUITING
Conditions: Thrombocythemia, Essential|Primary Myelofibrosis|Myelofibrosis|Post-polycythemia Vera Myelofibrosis|Post-essential Thrombocythemia Myelofibrosis|Polycythemia Vera
Interventions: DRUG: Bomedemstat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Lung Effect of Indacaterol and Tiotropium in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Indacaterol 150 μg|DRUG: Tiotropium 18 μg|DRUG: Placebo to indacaterol|DRUG: Placebo to tiotropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: phII Study of an HDAC Inhibitor in Very High-risk Relapsed/Refractory Hodgkin's Lymphoma Patients
Status: TERMINATED
Conditions: Hodgkin's Lymphoma
Interventions: DRUG: histone deacetylase inhibitor (ITF2357)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STUDY OF PF-07321332 IN HEALTHY PARTICIPANTS
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: PF-07321332 Dose 1|DRUG: PF-07321332 Dose 2|DRUG: PF-07321332 Dose 3|DRUG: PF-07321332 Dose 4|DRUG: PF-07321332 Dose 5|DRUG: PF-07321332 Dose 4 or Placebo (Fed)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Tosedostat With Capecitabine in Patients With Metastatic Pancreatic Adenocarcinoma
Status: TERMINATED
Conditions: Pancreatic Cancer|Cancer of Pancreas|Cancer of the Pancreas|Pancreas Cancer
Interventions: DRUG: Tosedostat|DRUG: Capecitabine|PROCEDURE: Fresh tissue biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tip-flexible Semi-rigid Ureterorenoscope Versus Flexible Ureteroscopy in Renal Calculi
Status: UNKNOWN
Conditions: Renal Calculi
Interventions: DEVICE: the tip-flexible ureterorenoscope|DEVICE: the classic flexible ureteroscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neo-TACE-HAIC for PVTT-HCC
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Portal Vein Thrombosis
Interventions: PROCEDURE: neo-TACE-HAIC+Surgery|PROCEDURE: Surgery alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Naltrexone for Impulse Control Disorders in Parkinson's Disease
Status: COMPLETED
Conditions: Impulse Control Disorder|Parkinson Disease
Interventions: DRUG: Naltrexone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of Three Universal Adhesives in Posterior Restorations
Status: RECRUITING
Conditions: Recurrent Caries
Interventions: OTHER: Universal adhesives application|OTHER: universal adhesive with bioactive properties|OTHER: Fluoride-releasing universal adhesive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of Bimekizumab Given as 1x2mL or 2x1mL Subcutaneous Injection Using an Autoinjector in Healthy Study Participants
Status: COMPLETED
Conditions: Healthy Study Participants
Interventions: DRUG: bimekizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Human ECM Implanted Within Microfracture Interstices & the Cartilage Defect in the Knee to Regenerate Hyaline Cartilage
Status: TERMINATED
Conditions: Articular Cartilage Disorder of Knee|Cartilage Damage|Microfractures
Interventions: BIOLOGICAL: microfracture surgery + HST003
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Megakaryocytic Progenitor Cells for Prophylaxis and Treatment of Thrombocytopenia
Status: UNKNOWN
Conditions: Hematological Diseases|Thrombocytopenia
Interventions: BIOLOGICAL: MPs|DRUG: thrombopoietin (TPO) and interleukin-11
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Protein Intake on Post Prandial Hyperglycemia in Children and Adolescents With Type1 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Hyperglycemia, Postprandial
Interventions: DIETARY_SUPPLEMENT: Whey protein isolate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Tesamorelin Effects on Liver Fat and Histology in HIV
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV)|Nonalcoholic Fatty Liver Disease (NAFLD)|Nonalcoholic Steatohepatitis (NASH)
Interventions: DRUG: tesamorelin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Cetuximab in Metastatic Penile Carcinoma (PENILANE)
Status: WITHDRAWN
Conditions: Squamous Cell Carcinoma of the Penis
Interventions: DRUG: Cetuximab|DRUG: TIP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methods of Pancreatic Stump Closure for Distal Pancreatectomy
Status: COMPLETED
Conditions: Pancreatectomy
Interventions: PROCEDURE: stapler combined with electrocautery|PROCEDURE: simple closure with a closure device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictive Executive Functioning Models Using Interactive Tangible-Graphical Interface Devices in Adults
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DEVICE: Groundskeeper for ADHD group|DEVICE: Groundskeeper for control group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Atomization Vs. Nebulization for Airway Topicalization During Awake Nasotracheal Fiberoptic Intubation
Status: COMPLETED
Conditions: Awake Fiberoptic Intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Effect of a Nasal Former in Nasal Deformities
Status: UNKNOWN
Conditions: Nose Deformity
Interventions: DEVICE: Use of customized nasal brace (Nasella) for nose deformities|PROCEDURE: corrective surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Fenugreek Extract on Markers of Muscle Damage and Inflammation in Untrained Males
Status: COMPLETED
Conditions: Muscle Damage|Inflammation
Interventions: OTHER: Sugar Pill|DIETARY_SUPPLEMENT: Fenugreek Extract, Low Dose|DIETARY_SUPPLEMENT: Fenugreek Extract, High Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Use of Transient Elastogaphy to Assess Diaphragm Function in Mechanically Ventilated Patients
Status: COMPLETED
Conditions: Ventilator Weaning|Intensive Care Unit
Interventions: DEVICE: Shear Wave Elastography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sarcopenia Prevention With a Targeted Exercise and Protein Supplementation Program
Status: ACTIVE_NOT_RECRUITING
Conditions: Sarcopenia|Frailty|Malnutrition; Protein|Fall
Interventions: DIETARY_SUPPLEMENT: Protein Supplement|DIETARY_SUPPLEMENT: Protein-free Supplement|PROCEDURE: Active Exercise|PROCEDURE: Control Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Registry Study of Patients Initiating a Course of Drug Therapy for Overactive Bladder in Taiwan, Korea and China
Status: COMPLETED
Conditions: Overactive Bladder (OAB)
Interventions: DRUG: mirabegron|DEVICE: solifenacin|DRUG: darifenacin|DRUG: imidafenacin|DRUG: tolterodine|DRUG: oxybutynin|DRUG: trospium|DRUG: fesoterodine|DEVICE: propiverine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Deep TMS for Comorbid Depression and Cognitive Impairment in Older Adults
Status: RECRUITING
Conditions: Major Depressive Disorder|Alzheimer Disease|Mild Cognitive Impairment
Interventions: DEVICE: Brainsway H1-Coil Deep TMS System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Three Chemotherapy Regimens for the Treatment of Patients With Newly Diagnosed Mantle Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Liver Lymphoma|Mantle Cell Lymphoma
Interventions: DRUG: Acalabrutinib|DRUG: Bendamustine|DRUG: Bendamustine Hydrochloride|DRUG: Cytarabine|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulsed Dye Laser in Treating Patients With Post Radiation Dysphonia
Status: COMPLETED
Conditions: Oral Complications of Radiation Therapy|Stage I Laryngeal Cancer|Stage II Laryngeal Cancer
Interventions: PROCEDURE: laser therapy|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Intravenous Iron Isomaltoside 1000 (Monofer®) Administered by Infusions to Iron-deficient Blood Donors
Status: COMPLETED
Conditions: Iron-deficiency
Interventions: DRUG: Iron isomaltoside 1000 (Monofer®)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Serotonin Selective Reuptake Inhibitor Treatment of Dual Diagnosis Post-traumatic Stress Disorder and Alcohol Problems
Status: COMPLETED
Conditions: PTSD|Alcohol Use Disorder
Interventions: DRUG: Sertraline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Tomography of Nephrolithiasis Evaluation
Status: COMPLETED
Conditions: Urolithiasis
Interventions: OTHER: Point-of-care Ultrasound|RADIATION: Radiology Ultrasound|OTHER: Radiology CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: TOngue/Palate Interactions Study
Status: RECRUITING
Conditions: Toothless
Interventions: DEVICE: Tongue pressure recordings with the PRESLA prothesis for the Arm1 (patients wearing the complete denture for the first time)|DEVICE: Tongue pressure recordings with the PRESLA prothesis for the Arm2 (patients used to wear the complete denture)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Ridge Preservation Comparing an Intrasocket Graft Alone to an Intrasocket Graft Plus a Facial Overlay Graft
Status: COMPLETED
Conditions: Clinical Efficacy
Interventions: PROCEDURE: Intrasocket graft|PROCEDURE: Intrasocket plus facial overlay graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cholesterol and Inflammation Lowering Via Bempedoic Acid, an ACL-inhibiting Regimen in HIV Trial (CLEAR HIV Trial)
Status: RECRUITING
Conditions: Dyslipidemias|Cardiovascular Diseases|HIV Infections|Atherosclerosis
Interventions: DRUG: Bempedoic acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Continence Pessary Versus Disposable Intravaginal Device Trial
Status: COMPLETED
Conditions: Female Stress Incontinence
Interventions: DEVICE: Continence Pessary|DEVICE: Poise Impressa (Disposable Intravaginal Device)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib Drug Drug Interaction Study in Healthy Male Subjects
Status: COMPLETED
Conditions: Drug Interactions
Interventions: DRUG: Sorafenib (Nexavar, BAY43-9006)|DRUG: Levothyroxine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Multiple Oral Doses of BIBR 1048 MS Solution in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIBR 1048 MS low|DRUG: BIBR 1048 MS medium 1|DRUG: BIBR 1048 MS medium 2|DRUG: BIBR 1048 MS high|DRUG: BIBR 1048 MS placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Conservative Treatments for Urinary Incontinence in Women
Status: RECRUITING
Conditions: Urinary Incontinence
Interventions: PROCEDURE: BT|PROCEDURE: bPFMT|PROCEDURE: iVES|PROCEDURE: BT + bPFMT|PROCEDURE: BT + iVES|PROCEDURE: bPFMT + iVES
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prospective Multicenter Evaluation of the MycoGenie Kit for the Diagnosis of Invasive Aspergillosis
Status: COMPLETED
Conditions: Invasive Aspergillosis in Patients With Onco-haematological Diseases
Interventions: DIAGNOSTIC_TEST: DNA extraction and detection of Aspergillus fumigatus in serum samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Barrett's Esophagus & Gastroesophageal Reflux Disease
Status: COMPLETED
Conditions: Barrett's Esophagus|GERD
Interventions: PROCEDURE: Endoscopy|PROCEDURE: Radiofrequency ablation protocol|PROCEDURE: Endoscopic mucosal resection protocol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Tolerability and Efficacy Study of Doxycycline Foam for the Prevention of EGFRI Skin Toxicity in Cancer Patients
Status: COMPLETED
Conditions: Rash Due to Epidermal Growth Factor Receptor Inhibitors
Interventions: DRUG: FDX104 (4% Doxycycline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of an Algorithm for Intensive s.c. Insulin Therapy in Emergency Room Patients With Hyperglycaemia
Status: COMPLETED
Conditions: Hyperglycemias
Interventions: DRUG: Novorapid ®, Novo Nordisk, Denmark
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of SBRT Plus Tislelizumab and Regorafenib in Unresectable or Oligometastatic HCC
Status: RECRUITING
Conditions: Unresectable Hepatocellular Carcinoma|Oligometastatic Disease
Interventions: COMBINATION_PRODUCT: SBRT plus tislelizumab and regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STroke Secondary Prevention With Catheter ABLation and EDoxaban for Patients With Non-valvular Atrial Fibrillation: STABLED Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Ischemic Stroke|Atrial Fibrillation Non-Rheumatic
Interventions: PROCEDURE: Catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Motorized Platform and Autonomy Among the Frail and Pre-frail Older Adult (PLATAUTONOMIE)
Status: WITHDRAWN
Conditions: Fragility
Interventions: DEVICE: plate-forme Hu360®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Shifting Perspectives R33 Phase: Enhancing Outcomes in Anorexia Nervosa With CRT
Status: RECRUITING
Conditions: Anorexia Nervosa
Interventions: BEHAVIORAL: Family Based Treatment|BEHAVIORAL: Cognitive Remediation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Osteopathic Manipulation Makes a Neuropsychological Difference
Status: ACTIVE_NOT_RECRUITING
Conditions: Cognitive Change|Musculoskeletal Pain
Interventions: OTHER: Osteopathic Manipulative Treatment|OTHER: Control- No Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Topical Diclofenac on Tumor Metabolism
Status: COMPLETED
Conditions: Actinic Keratoses
Interventions: DRUG: 3% diclofenac in 2.5% hyaluronic acid gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Crenolanib vs Midostaurin Following Induction Chemotherapy and Consolidation Therapy in Newly Diagnosed FLT3 Mutated AML
Status: RECRUITING
Conditions: Newly Diagnosed FLT3 Mutated AML
Interventions: DRUG: Crenolanib|DRUG: Midostaurin|DRUG: Cytarabine|DRUG: Duanorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Trimebutine Maleate (NEWBUTIN SR 300 mg Tab)for Treatment of Post Operative Nausea and Vomiting
Status: UNKNOWN
Conditions: Nausea|Vomiting
Interventions: DRUG: Trimebutine Maleate (NEWBUTIN SR 300 mg Tab)|DRUG: Metoclopramide hydrochloride monohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Prenatal Mentalization-focused 4D Ultrasound and a Pregnancy Diary Intervention for Substance-abusing Women
Status: COMPLETED
Conditions: Substance-Related Disorders|Pregnancy, High Risk|Prenatal Care|Maternal-Fetal Relations|Parenting|Depression|Anxiety|Perinatal Outcome|Fetal Exposure During Pregnancy
Interventions: BEHAVIORAL: Prenatal mentalization intervention|OTHER: Prenatal obstetric treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Dexmedetomidine After Intra-nasal Dosing in Children
Status: COMPLETED
Conditions: Heart Disease
Interventions: DRUG: Dexmedetomidine 1mcg/kg Intranasal|DRUG: Dexmedetomidine 2mcg/kg Intranasal|DRUG: Dexmedetomidine 1mcg Intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Clinical Investigation Examining the Performance and Handling of New 2-piece Ostomy Products in 28 People With an Ileostomy.
Status: COMPLETED
Conditions: Ileostomy - Stoma
Interventions: DEVICE: Coloplast Test A|DEVICE: Coloplast Test B|DEVICE: Own product|DEVICE: Coloplast Test C|DEVICE: Coloplast Test D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa
Status: NOT_YET_RECRUITING
Conditions: Depression|Posttraumatic Stress Disorder|Pregnancy Related|Medication Adherence
Interventions: BEHAVIORAL: Brief CBT-Based Intervention|OTHER: Enhanced Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Omega-3 Fatty Acids on the Human Gene Expression
Status: COMPLETED
Conditions: Hyperlipidemia|Healthy
Interventions: DIETARY_SUPPLEMENT: Fish oil|DIETARY_SUPPLEMENT: Placebo (corn oil)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Hormonal Replacement Therapy and Small Artery Function
Status: COMPLETED
Conditions: Menopause
Interventions: DRUG: Femanest|DRUG: gestapuran|DRUG: placebo|DRUG: Femanest plus Gestapuran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Safety and Efficacy of Posaconazole Versus Voriconazole for the Treatment of Invasive Aspergillosis (MK-5592-069)
Status: COMPLETED
Conditions: Fungal Infections|Invasive Pulmonary Aspergillosis
Interventions: DRUG: Posaconazole|DRUG: Voriconazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Plus Radiation Therapy in Treating Patients With Refractory or Relapsed Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: carmustine|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: etoposide|DRUG: ifosfamide|DRUG: melphalan|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SX-682 Treatment in Subjects With Metastatic Melanoma Concurrently Treated With Pembrolizumab
Status: RECRUITING
Conditions: Melanoma Stage III|Melanoma Stage IV
Interventions: DRUG: SX-682|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reverse Remodeling Effects of CDR132L in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Cardiac Hypertrophy
Status: WITHDRAWN
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: CDR132L|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Caries Lesion Management Observational Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Initial Caries|Arrested Dental Caries|Cavitated Caries|Dental Caries|Dental Caries in Children
Interventions: DRUG: Curodont Repair Fluoride Plus|DEVICE: Silver Diamine Fluoride|DEVICE: Glass Ionomer Sealant|DEVICE: Fluoride varnish|DRUG: Fluoride toothpaste
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: EXPERT CTO: Evaluation of the XIENCE PRIME™ LL and XIENCE Nano™ Everolimus Eluting Coronary Stent Coronary Stents, Performance, and Technique in Chronic Total Occlusions
Status: COMPLETED
Conditions: Coronary Artery Disease (CAD)|Chronic Total Occlusion (CTO)
Interventions: DEVICE: CTO Treatment Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention to Reduce Early (Peanut) Allergy in Children
Status: ENROLLING_BY_INVITATION
Conditions: Food Allergy Peanut|Food Allergy in Infants
Interventions: OTHER: iREACH CDS Tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Implantable Cardioverter Defibrillator Versus Optimal Medical Therapy In Patients With Variant Angina Manifesting as Aborted Sudden Cardiac Death
Status: RECRUITING
Conditions: Angina Pectoris, Variant|Sudden Cardiac Death
Interventions: DEVICE: Implantable Cardioverter Defibrillator|DRUG: Optimal Medical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of R:GEN as Intervention in Subjects With Early Stages of AMD for Safety and Exploratory Efficacy Outcomes
Status: COMPLETED
Conditions: Early Age Related Macular Degeneration (Disorder)
Interventions: DEVICE: R:GEN Laser System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Worktime Planning Tools in the Finnish Public Sector. A Quasi-experimental Study (PLANTOOLS)
Status: COMPLETED
Conditions: Work Stress|Sleep Disturbance
Interventions: OTHER: Shift planning with self-rostering and shift ergonomics|OTHER: Shift planning with shift ergonomics
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial of Selumetinib and Bromodomain Inhibitor With Durvalumab for Sarcomas
Status: NOT_YET_RECRUITING
Conditions: MPNST|NF1|Sarcoma
Interventions: DRUG: Selumetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Noninvasive Ventilation in vs Postoperative Standard Care in High Risk Patients According to ARISCAT Score
Status: UNKNOWN
Conditions: Surgical Patients|Pulmonary Complication
Interventions: PROCEDURE: Prophylactic non-invasive ventilation|PROCEDURE: postoperative standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: START: Sensipar Treatment Algorithm to Reach K/DOQI Targets in Chronic Kidney Disease Subjects With Secondary Hyperparathyroidism
Status: COMPLETED
Conditions: Kidney Disease|Secondary Hyperparathyroidism|Chronic Kidney Disease
Interventions: DRUG: Sensipar
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intake of Nitrate-rich Vegetables and Their Effect on Inflammatory Molecules and Oral Microbiota of Patients With Periodontitis
Status: RECRUITING
Conditions: Periodontal Diseases|Periodontitis
Interventions: DIETARY_SUPPLEMENT: Intake of nitrate rich vegetables
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Massage Versus Massage With Post Isometric Relaxation Exercises in Temporomandibular Disorders
Status: NOT_YET_RECRUITING
Conditions: Pain, Joint
Interventions: DIAGNOSTIC_TEST: Massage with post isometric relaxation exercises|DIAGNOSTIC_TEST: Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH