pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Bioequivalence Study of Crushed Sofosbuvir/Velpatasvir Compared to the Whole Tablet
Status: WITHDRAWN
Conditions: HCV
Interventions: DRUG: sofosbuvir/velpatasvir tablet|DRUG: sofosbuvir/velpatasvir crushed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Use of Impedance Cardiography to Decrease the Risk of Pre-eclampsia in Obese Patients
Status: UNKNOWN
Conditions: Obesity, Morbid|Preeclampsia
Interventions: DRUG: Labetalol Hydrochloride 200 mg|DRUG: NIFEdipine 60 mg|DRUG: Atenolol 25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Rotational Atherectomy on Coronary Microcirculation
Status: RECRUITING
Conditions: Stable Angina|Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: coronary pressure/temperature sensor-tipped guidewire|DIAGNOSTIC_TEST: Angiography-derived index of microcirculatory resistance (IMRangio)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cell Therapy for Bronchopulmonary Dysplasia in Preterm Babies
Status: COMPLETED
Conditions: Bronchopulmonary Dysplasia
Interventions: BIOLOGICAL: Mesenchymal Stem Cell (MSC) therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Preventing Antibiotic-Associated DiarRhea Using Erceflora
Status: COMPLETED
Conditions: Diarrhea, Infantile
Interventions: DRUG: Bacillus Clausii Multi ATB Resist|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Balloon Catheter Combined With Oxytocin Induction Among the Pregnant Women With Previous Cesarean Section
Status: RECRUITING
Conditions: Trial of Labor After Cesarean|Vaginal Birth After Cesarean|Bishop Score|Failed Mechanical Induction|Balloon Catheter for Labor Induction|Unfavorable Cervix
Interventions: DEVICE: Balloon catheter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Of ¹²⁹XE MRI To Assess Disease Progression In Patients With COPD Treated With Or Without Azithromycin And Standard-of-Care Medications
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Azithromycin|OTHER: HP xenon (¹²⁹XE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Effectiveness and Safety of HAIC in Combination With Adebrelimab and Bevacizumab for Potentially Resectable Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Adebrelimab|Hepatocellular Carcinoma
Interventions: DRUG: Adebrelimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Maraviroc and Boosted Atazanavir Dual Regimen in Stable HIV-infected Patients
Status: WITHDRAWN
Conditions: HIV Infection
Interventions: DRUG: maraviroc (300 mg QD) + atazanavir/ritonavir (300 and 200 mg /100 mg QD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CardioMEMS Heart Sensor Allows Monitoring of Pressure to Improve Outcomes in NYHA Class III Heart Failure Patients
Status: COMPLETED
Conditions: Heart Failure, Congestive
Interventions: DEVICE: HF Pressure Measurement System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Closed Loop Stimulation, Cognitive Performance, and Quality of Life in Pacemaker Patients
Status: COMPLETED
Conditions: Cardiac Pacing, Artificial
Interventions: DEVICE: Rate-adaptive pacemaker: accelerometer|DEVICE: Rate-adaptive pacemaker: Closed Loop Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study Assessing the Safety of Cord Blood Product in Sacroiliac Joint Syndrome (SIJ)
Status: RECRUITING
Conditions: Sacroiliac; Backache|Pain, Back
Interventions: BIOLOGICAL: PremierMaxCB®-Platinum (CFL001);
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013)
Status: UNKNOWN
Conditions: Glioblastoma WHO Grade IV|Diffuse Midline Glioma Histone 3 K27M WHO Grade IV|Anaplastic Astrocytoma WHO Grade III|Diffuse Intrinsic Pontine Glioma|Gliomatosis Cerebri
Interventions: DRUG: Temozolomide + Valproic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Elastic Power in Predicting the Severity and Mortality in Adult Patients With ARDS Due to Pneumonia
Status: RECRUITING
Conditions: Acute Respiratory Distress Syndrome
Interventions: OTHER: calculation of the elastic power of the lung in case of the ARDS and corolating with the severity index of Berline definition of ARDS in respect to mortality and severity
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Digital Version of Holistic Healthy Life Education(e2HLE)
Status: RECRUITING
Conditions: Hypertension
Interventions: BEHAVIORAL: Digital version of Holistic Healthy Life Education|OTHER: Waitlist control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: In Vitro Maturation (IVM) of Human Oocytes
Status: TERMINATED
Conditions: Infertility
Interventions: PROCEDURE: in vitro maturation|PROCEDURE: Polar Body Biopsy with preimplantation genetic screening
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antibacterial Effect of Nano Silver Fluoride vs Chlorhexidine on Occlusal Carious Molars Treated With Partial Caries Removal Technique
Status: COMPLETED
Conditions: Dental Caries
Interventions: DRUG: Nano silver fluoride solution|DRUG: Cavity Cleanser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Aerobic Exercise on Immune Response and Side Effects of Cancer Treatments
Status: COMPLETED
Conditions: Colorectal Cancer Stage IV
Interventions: OTHER: Resting state (Control)|OTHER: Moderate Intensity Continuous Exercise (MICE)|OTHER: High Intensity Interval Exercise (HIIE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dexmedetomidine Versus Propofol for Continuous Sedation in the Intensive Care Unit (ICU)
Status: COMPLETED
Conditions: Continuous Sedation in Initially Sedated Adults in ICU
Interventions: DRUG: Dexmedetomidine|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Welgenaleucel (UWC19) in Patients With Relapsed or Refractory B-cell Lymphoma
Status: UNKNOWN
Conditions: B-cell Non-Hodgkin Lymphoma
Interventions: GENETIC: Welgenaleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interventional Study on the Evaluation of Functionality, Safety of a Robotic Prosthesis for Transtibial Amputations
Status: COMPLETED
Conditions: Amputation|Amputation; Traumatic, Leg, Lower
Interventions: DEVICE: WRL TTP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: CO2-Patterns During Hyperoxia and Physical Exercise in COPD
Status: UNKNOWN
Conditions: COPD
Interventions: OTHER: Oxygen therapy|OTHER: Medical Air|OTHER: 10L/min O2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Topotecan in Combination With Pemetrexed in Patients With Advanced Malignancies
Status: COMPLETED
Conditions: Ovarian Cancer|Endometrial Cancer|Cervical Cancer|Lung Cancer
Interventions: DRUG: pemetrexed|DRUG: topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Preoperative Management of Angiotensin Converting Enzyme Inhibitor (ACEi) and Angiotensin Receptor Blocker (ARB) Medications
Status: COMPLETED
Conditions: Hypertension
Interventions: PROCEDURE: Preoperative ACEi/ARB management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Epcoritamab in Patients With Follicular Lymphoma Not Accomplishing a Complete Response With Upfront Chemoimmunotherapy
Status: NOT_YET_RECRUITING
Conditions: Lymphoma|Follicular Lymphoma|Lymphoma,Non-Hodgkin|Lymphoma, Non-Hodgkin's, Adult
Interventions: DRUG: Epcoritamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interferon Alfa Plus Sargramostim in Treating Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia
Status: TERMINATED
Conditions: Leukemia
Interventions: BIOLOGICAL: recombinant interferon alfa|BIOLOGICAL: sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Verizon mHealth Solution for Patients With Peripheral Artery Disease (PAD)
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: OTHER: Fitbit Physical Activity Monitor|OTHER: mHealth Glucometer|OTHER: mHealth Blood Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Capecitabine and Paclitaxel (Albumin-Stabilized Nanoparticle Formulation) in Treating Women Undergoing Surgery for Stage II or Stage III Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: capecitabine|DRUG: paclitaxel albumin-stabilized nanoparticle formulation|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of NMN on Muscle Recovery and Physical Capacity in Healthy Volunteers With Moderate Physical Activity
Status: COMPLETED
Conditions: Physical Activity|Muscle Recovery
Interventions: DIETARY_SUPPLEMENT: Nicotinamide mononucleotide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: BI 6727 (Volasertib) in Combination With Cisplatin or Carboplatin in Patients With Advanced or Metastatic Solid Tumour
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: BI-6727|DRUG: BI 6727
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Achieving Cannabis Cessation-Evaluating N-Acetylcysteine Treatment
Status: COMPLETED
Conditions: Cannabis Dependence
Interventions: DRUG: N-Acetylcysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of the Massage on Cramp Frequency, Cramp Severity, and Sleep Quality
Status: COMPLETED
Conditions: Muscular Cramps|Hemodialysis
Interventions: BEHAVIORAL: intradialytic massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Individual Dose-escalated Bi-daily Subcutaneously (sc) Ghrelin in Cancer Cachexia: a Phase I/II Study
Status: COMPLETED
Conditions: Advanced Cancer|Cachexia
Interventions: DRUG: ghrelin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lactobacillus Plantarum 299v in Colon Surgery
Status: COMPLETED
Conditions: Bacterial Translocation|Inflammation|Cell Proliferation
Interventions: DIETARY_SUPPLEMENT: Lactobacillus plantarum 299v in oatmeal drink|DIETARY_SUPPLEMENT: Oatmeal drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Carbetocin Myocardium Trial 2014 Part 2
Status: COMPLETED
Conditions: Pregnancy Complications
Interventions: DRUG: Oxytocin|DRUG: Carbetocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: First-in-human Interleukin-15-transpresenting Wilms' Tumor Protein 1-targeting Autologous Dendritic Cell Vaccination in Cancer Patients
Status: RECRUITING
Conditions: Esophageal Cancer|Pancreas Cancer|Ovarian Cancer|Liver Cancer
Interventions: BIOLOGICAL: IL15-transpresenting WT1-targeted Dendritic Cell Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Resistance Training With High vs. Light-moderate Loads on Muscle-tendon Function in the Elderly
Status: COMPLETED
Conditions: Aging|Sarcopenia|Frail Elderly Syndrome
Interventions: BEHAVIORAL: High Intensity resistance training (12 weeks)|BEHAVIORAL: Light-moderate intensity resistance training (12 weeks)|BEHAVIORAL: Control (12 weeks)|BEHAVIORAL: One High Intensity resistance training session|BEHAVIORAL: One Light-moderate intensity resistance training session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acute Effects of a Flutter Device in COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: Flutter valve exercises|DEVICE: Flutter Sham exercises|DEVICE: Flutter and bronchodilator exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intracervical Lidocaine Gel for IUD Insertional Pain
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: 2% lidocaine gel|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Palbociclib and Sasanlimab for the Treatment of Advanced Clear Cell Renal Cell Carcinoma (ccRCC) or Papillary Renal Cell Carcinoma (pRCC)
Status: RECRUITING
Conditions: Advanced Clear Cell Renal Carcinoma (Ccrcc)|Papillary Renal Cell Carcinoma (Prcc)
Interventions: DRUG: Sasanlimab|DRUG: Palbocicilib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Individualized Dietary Advice in Improving Diet Quality and Cardiovascular Health
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases
Interventions: BEHAVIORAL: Personalised dietary advice and educational material|BEHAVIORAL: Educational material
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Peritonsillar Abscess: Aspiration Versus Tonsillectomy a Chaud
Status: UNKNOWN
Conditions: Peritonsillar Abscess
Interventions: PROCEDURE: Aspiration|PROCEDURE: Tonsillectomy a chaud|DRUG: Penicillin V + metronidazol (Penicillin allergy: Clindamycin alone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating of Calcineurin Inhibitors Versus Sirolimus in Renal Allograft Recipient
Status: TERMINATED
Conditions: Kidney Transplantation
Interventions: DRUG: Sirolimus+MMF or MPS or AZA+Steroid|DRUG: Calcineurin Inhibitors (either cyclosporine or tacrolimus)+MMF or MPS or AZA+Steroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human-Animal Interaction to Promote Recovery Following Pediatric Brain Injury
Status: COMPLETED
Conditions: Brain Injuries|Acquired Brain Injury|Traumatic Brain Injury
Interventions: OTHER: AAT - Dog|OTHER: TAU - No Dog
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Comparisons of Leucine-Metformin Combinations on Blood Glucose Levels In Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Low Metformin|DRUG: Metformin|DRUG: Mid Metformin|DRUG: High Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Co-Administration of Meningococcal Vaccine GSK134612 With Infanrix Hexa™ Versus Individual Administration of Each Vaccine
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: Meningococcal vaccine GSK134612|BIOLOGICAL: Infanrix™ hexa|BIOLOGICAL: Meningitec™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Prolonged Use of Bivalirudin 4 Hours After ePCI (COBER Study)
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DRUG: prolonged continuous use of bivalirudin|DRUG: bivalirudin use during ePCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase I/II a Study of Decitabine in Combination With Genistein in Pediatric Relapsed or Refractory Malignancies
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Decitabine and Genistein
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cranberry Tablets Versus Nitrofurantoin Prophylaxis for Urinary Tract Infection Prevention After Urogynecologic Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Urinary Tract Infections|Pelvic Organ Prolapse|Urinary Incontinence
Interventions: DRUG: Nitrofurantoin Prophylaxis/Placebo|DRUG: Cranberry capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Dextrose Prolotherapy Versus LLLT in Treatment of Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: PROCEDURE: LLLT application|PROCEDURE: dextrose injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Novel Interventions for Low Back Pain in US Military Veterans: A Randomized Controlled Adaptive Phase II Trial
Status: NOT_YET_RECRUITING
Conditions: Chronic Low Back Pain
Interventions: DRUG: Pregnenolone|DRUG: DHEA|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Water Flosser vs String Floss vs Manual Toothbrush Safety
Status: COMPLETED
Conditions: Soft Tissue Injuries
Interventions: DEVICE: Water Flosser|DEVICE: String Floss|DEVICE: Manual Toothbrush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: To Evaluate the Safety, and Immunogenicity of Vaccine Candidate Against COVID-19, in Healthy Adults
Status: UNKNOWN
Conditions: Coronavirus Disease (COVID-19)
Interventions: BIOLOGICAL: CoVepiT (OSE13E)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TAP Block for Laparoscopic Appendicectomy in Adults
Status: WITHDRAWN
Conditions: Acute Appendicitis
Interventions: PROCEDURE: Ultrasound guided Transversus Abdominis Plane (TAP) bock|PROCEDURE: Local anaesthetic infiltration of laparoscopic port sites
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PRGN-3006 Adoptive Cellular Therapy for CD33-Positive Relapsed or Refractory AML, MRD Positive AML or Higher Risk MDS
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: PRGN-3006 T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Ascending-dose Study of the Safety, Tolerability, and Pharmacokinetics of REGN1908-1909 in Allergic, Adult Subjects
Status: COMPLETED
Conditions: Allergy
Interventions: DRUG: REGN1908-1909|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Posttraumatic Osteomyelitis in Patients With High-energy Tibial Fractures and Biomarkers
Status: COMPLETED
Conditions: Osteomyelitis Tibia|Surgical Site Infection
Interventions: DIAGNOSTIC_TEST: blood sample on admission (ADD), first postoperative day (POD1) and fourth postoperative day (POD4)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Double Tract Reconstruction After Total Gastrectomy in Patients With Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: PROCEDURE: Reconstruction after total gastrectomy|PROCEDURE: Reconstruction after total gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Reduction of Systemic Lupus Erythematosus Flares :Study PLUS
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: versus hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate Immunological Response to PD-1 Inhibition in Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: [18F]F-AraG PET Scan, baseline + post anti-PD-1 therapy.|DRUG: [18F]F-AraG PET Scan, baseline + post anti-PD-1 therapy.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of LY3532226 in Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: LY3532226|DRUG: Placebo|DRUG: Dulaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparing The PK Of Aramchol Meglumine Granules To Aramchol Free Acid Tablets
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DRUG: Aramchol meglumine|DRUG: Aramchol free acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EPIX, a Study to Gather More Information About Characteristics of Patients and Other Factors Which May Contribute to Survival Over a Long Period of Time in Patients With Metastatic Castration-resistant Prostate Cancer (mCRPC) Treated With Radium-223 (Xofigo)
Status: COMPLETED
Conditions: Metastatic Castration Resistant Prostate Cancer (mCRPC)
Interventions: DRUG: Radium-223 dichloride (Xofigo, BAY88-8223)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison Between 2 Doses of Misoprostol Before Intrauterine Device
Status: COMPLETED
Conditions: Pain Relief
Interventions: DRUG: misoprostol 200|DRUG: misoprostol 400
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Distribution of Fortified Yoghurt in Senegal to Decrease Children's Anemia and Improve Milk Supply
Status: COMPLETED
Conditions: Anemia|Iron-Deficiency
Interventions: DIETARY_SUPPLEMENT: Micronutrient-fortified yoghurt|BEHAVIORAL: BCC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Probiotics on Endurance Athletes' Microbiome at Rest and Post-race
Status: COMPLETED
Conditions: Gut Microbiome|Gut Microbiota|Aerobic Exercise|Gastrointestinal Tract Irritation|Athletes|Probiotics
Interventions: DIETARY_SUPPLEMENT: Probiotics (Lab4 probiotics, Cultech, Port Talbot, Wales, UK)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ultrasound as Adjunct Therapy for Increasing Fusion Success After Lumbar Surgery
Status: TERMINATED
Conditions: Lumbar Degenerative Disc Disease
Interventions: DEVICE: Exospine sham|DEVICE: Exospine|DEVICE: Exogen 4000+|DEVICE: Exogen 4000+ sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selective Coronary Revascularization in Carotid Artery Disease Patients After Carotid Revascularization (SCORECAD Trial)
Status: RECRUITING
Conditions: Carotid Stenosis|Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: Coronary CT angiography and FFRct analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Vaniprevir (MK-7009) in Participants With Chronic Hepatitis C Infection After Participation in Other Vaniprevir Studies (MK-7009-028)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Vaniprevir 600 mg b.i.d.|DRUG: Vaniprevir 300 mg b.i.d.|DRUG: Pegylated interferon|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerance of Infants With Cow's Milk Protein Allergy to Extensively Hydrolyzed Rice Protein or Casein Infant Formulas
Status: COMPLETED
Conditions: Cow Milk Protein Sensitivity|Tolerance|Growth Failure
Interventions: OTHER: Damira/Celia peptide hydrolyzed casein|OTHER: Picot riz/Celia rice/Sanutri arroz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunomodulatory Biomimetic Device to Treat Myocardial Stunning in End-stage Renal Disease Patients
Status: TERMINATED
Conditions: End Stage Renal Disease|Acute Kidney Injury|Chronic Kidney Disease Stage 5
Interventions: DEVICE: Hemodialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Ketone Esters in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease|Ketosis
Interventions: DIETARY_SUPPLEMENT: Ketone Ester Elite endurance Nutrition Drink|OTHER: Stool Sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Propofol-ketamine or Propofol-fentanyl for Procedural Sedation in the Short-term Gynecological Case
Status: COMPLETED
Conditions: Ketamine|Sedation|Gynecologic Disease
Interventions: DRUG: Ketamine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination of Probiotic and Calcium in Healthy Adults
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DIETARY_SUPPLEMENT: calcium and probiotic|DIETARY_SUPPLEMENT: probiotic|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tax First-line Chemotherapy With Different Doses and Then Maintenance Therapy
Status: COMPLETED
Conditions: Lung Neoplasms
Interventions: DRUG: Docetaxel|DRUG: Cisplatin|OTHER: Best supportive care (BSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Delayed Remote Ischemic Preconditioning on Myocardial Injury
Status: COMPLETED
Conditions: Myocardial Injury
Interventions: PROCEDURE: delayed remote ischemic preconditioning|PROCEDURE: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Acupuncture on Symptoms of Stable Angina
Status: RECRUITING
Conditions: Angina, Stable
Interventions: PROCEDURE: Acupuncture|OTHER: Attention control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Grape and Pomegranate Polyphenols in Postprandial Glucose and Related Parameters
Status: COMPLETED
Conditions: Subjects With Abdominal Obesity
Interventions: DIETARY_SUPPLEMENT: Mixture of grape pomace and pomegranate pomace|DIETARY_SUPPLEMENT: Mixture of grape pomace and pomegranate pomace|DIETARY_SUPPLEMENT: Mixture of grape pomace and pomegranate pomace
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Tisagenlecleucel in Adult Patients With Refractory or Relapsed Follicular Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Follicular Lymphoma
Interventions: BIOLOGICAL: tisagenlecleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of ACT-132577 on the Pharmacokinetics of Midazolam and 1-hydroxy Midazolam in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Midalozam|DRUG: Aprocitentan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Hepatitis B Vaccination in HIV-infected Persons
Status: COMPLETED
Conditions: HIV Infections|Hepatitis B
Interventions: BIOLOGICAL: HBVAXPRO, Hepatitis B (Recombinant) vaccine, 10 mcg/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Demonstrate Noninferiority in Efficacy and to Assess Safety of CT-P13 in Patients With Active Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: CT-P13|BIOLOGICAL: Remicade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Double-Blind Study Testing the Effects of Pregabalin on Diabetic Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathy
Interventions: DRUG: Pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Medication Adherence Patterns in Rheumatic Diseases: A Behavioral Trial
Status: COMPLETED
Conditions: Rheumatic Diseases|Gout|Adherence, Medication|Lupus Erythematosus, Systemic
Interventions: BEHAVIORAL: Cue-Reward Intervention|BEHAVIORAL: Cue-Reward Intervention with possible intensification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Trial of Acupuncture for Reduction of Post-Colectomy Ileus
Status: COMPLETED
Conditions: Postoperative Ileus|Colon Cancer|Pain, Postoperative|Postoperative Nausea and Vomiting
Interventions: OTHER: Acupuncture|OTHER: Sham Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Combination of an Anti-Cancer Drug, Iadademstat, With Other Anti-Cancer Drugs (Venetoclax and Azacitidine) for Treating AML
Status: NOT_YET_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|DRUG: Iadademstat|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of Implantation Of Retinal Pigment Epithelium In Subjects With Acute Wet Age Related Macular Degeneration
Status: UNKNOWN
Conditions: Age Related Macular Degeneration
Interventions: BIOLOGICAL: PF-05206388
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Ramelteon in Subjects With Mild to Moderate Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DRUG: Ramelteon or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FUSA With Intratumoral PolyICLC in Regionally Advanced Resectable Melanoma
Status: NOT_YET_RECRUITING
Conditions: Advanced Melanoma
Interventions: DEVICE: Echopulse or Echopulse HD|DRUG: PolyICLC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-flow Nasal Cannula vs. Helmet PSV vs. Helmet CPAP During Respiratory Failure
Status: COMPLETED
Conditions: Respiratory Failure|Hypoxemia
Interventions: OTHER: Respiratory support (High-flow oxygen therapy)|OTHER: Respiratory support (Helmet PSV)|OTHER: Respiratory support (Helmet CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Femoral Closure Versus Radial Compression Devices Related to Percutaneous Coronary Interventions Study
Status: COMPLETED
Conditions: Arterial Closure Device|Percutaneous Coronary Intervention (PCI)|Access Site Bleeding|Adverse Cardiac Events
Interventions: DEVICE: TR Band (TM)|DEVICE: AngioSeal|DEVICE: StarClose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Deficiency Causes Immune Dysfunction and Enables or Perpetuates the Development of Rheumatoid Arthritis
Status: WITHDRAWN
Conditions: Arthritis, Rheumatoid|Vitamin D Deficiency
Interventions: DRUG: Placebo in arm A and Vitamin D in arm B|DRUG: vitamin D 3 for arm A ,and matching placebo for arm B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Effect of 3T Pu'er Tea in Regulating Glucose and Lipid Metabolism
Status: ENROLLING_BY_INVITATION
Conditions: Overweight|Obesity
Interventions: OTHER: 3T Pu'er tea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy and Chemotherapy in Treating Patients With Hodgkin's Disease
Status: COMPLETED
Conditions: Hodgkin Lymphoma
Interventions: BIOLOGICAL: bleomycin sulfate|DRUG: dacarbazine|DRUG: doxorubicin hydrochloride|DRUG: vinblastine|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Trial of 12 Weeks of Treatment With Nebulized SUN-101 in Patients With COPD
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: SUN-101 50 mcg BID eFlow (CS) nebulizer|DRUG: SUN-101 25 mcg BID eFlow (CS) nebulizer|DRUG: Placebo BID eFlow Closed System (CS) nebulizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Six Patient Information Leaflets (PIL) on Doctor Patient Communication
Status: COMPLETED
Conditions: Ankle Sprain|Infectious Colitis|Diverticulitis|Pyelonephritis|Prostatitis|Pneumonitis
Interventions: PROCEDURE: Patient Information Leaflet (PIL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Efficacy of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: OC-01 (varenicline) nasal spray|DRUG: Placebo (vehicle) nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: New Versus Existing Auto-titrating CPAP Device to Treat Obstructive Sleep Apnea in Adults
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DEVICE: Compumedics Somnilink SPAP - Auto-titrating CPAP|DEVICE: Resmed Autoset S8 - Auto-titrating CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Personalized Caplacizumab Regimen Based on ADAMTS13 Activity Monitoring in Adult aTTP
Status: UNKNOWN
Conditions: Thrombotic Thrombocytopenic Purpura, Acquired
Interventions: DRUG: Caplacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK2330672 Administered With Metformin to Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: GSK2330672|DRUG: Placebo|DRUG: Sitagliptin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison Study of Pain Relief From Dysmenorrhea Between the Vipon Tampon and Ibuprofen
Status: COMPLETED
Conditions: Dysmenorrhea
Interventions: DEVICE: Vipon|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acetazolamide and Exercise Performance at Altitude
Status: COMPLETED
Conditions: Hypoxia|Exercise Performance|Cognitive Function|Dexterity
Interventions: DRUG: Acetazolamide Pill|DRUG: Placebo pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy Study of the Treatment of Kidney Infections With Short Course Levofloxacin
Status: TERMINATED
Conditions: Acute Uncomplicated Pyelonephritis
Interventions: DRUG: Levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison Study Between the Fixed Dose Triple Combination of Fluticasone Furoate/ Umeclidinium/ Vilanterol Trifenatate (FF/UMEC/VI) With Budesonide/Formoterol in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Triple FF/UMEC/VI|DRUG: Placebo to match FF/UMEC/VI|DRUG: Budesonide/Formoterol|DRUG: Placebo to match Budesonide/Formoterol combination|DRUG: Albuterol/salbutamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reconstructions With Back Donor Site Flaps and Validation of Quality of Life Scales
Status: RECRUITING
Conditions: Breast Cancer
Interventions: PROCEDURE: Latissimus dorsi flap|PROCEDURE: Thoracodorsal artery perforator flap to breast|PROCEDURE: Deep inferior epigastric perforator flap
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Whole-Body Hyperthermia in Treating Patients With Recurrent Ovarian Epithelial, Fallopian Tube, or Peritoneal Cancer
Status: UNKNOWN
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: carboplatin|DRUG: ifosfamide|PROCEDURE: hyperthermia treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEs
Status: RECRUITING
Conditions: Breast Cancer|Breast Cancer Female|Metastatic Triple-Negative Breast Carcinoma|ER Positive Breast Cancer|HER2-negative Breast Cancer|HER2 Negative Breast Carcinoma|ER-negative Breast Cancer
Interventions: DRUG: Datopotamab Deruxtecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Studying Physiological Effects of Probiotic Pills in Patients With Abdominal Pain/Discomfort and Bloating
Status: COMPLETED
Conditions: Abdominal Pain|Abdominal Discomfort|Bloating|Functional Bowel Disorders
Interventions: DIETARY_SUPPLEMENT: Single probiotic arm of L-NCFM alone|DIETARY_SUPPLEMENT: Blend probiotic arm of L-NCFM and B-LBi07
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessment of Fit of Novel N95 Style Transparent Face Masks
Status: NOT_YET_RECRUITING
Conditions: Respiratory Disease|Infection, Coronavirus|Respiratory Tract Infections
Interventions: DEVICE: SEEUS95 Transparent mask|DEVICE: CrystalGuard Mask|DEVICE: N95 face mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Immune Response to a Therapeutic HIV Vaccine Followed by Treatment Interruption in Patients With Acute or Recent HIV Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: MRKAd5 HIV-1 gag/pol/nef|BIOLOGICAL: MRKAd5 HIV-1 gag/pol/nef placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Improving Response to Intervention in Students With or at Risk of Reading Disabilities
Status: COMPLETED
Conditions: Reading Problem
Interventions: BEHAVIORAL: Reading|BEHAVIORAL: Mindset|BEHAVIORAL: Reading Embedded with Mindset|BEHAVIORAL: Business as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oral Acarbose Treatment in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: EMS Acarbose|DRUG: Bayer Acarbose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Program of Screening, Prevention and Elimination of Hepatitis C in Penitentiary Institutions in Cantabria (JAILFREE-C)
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: sofosbuvir|DRUG: ledipasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pooled Unrelated Donor Umbilical Cord Blood Transplant For Hematologic Malignancy Needing Allogeneic Stem Cell Transplant Without Related HLA-Match
Status: TERMINATED
Conditions: Acute Myelogenous Leukemia|Acute Lymphocytic Leukemia|Chronic Lymphocytic Leukemia|Chronic Myelogenous Leukemia|Hodgkins Disease|Non-Hodgkins Lymphoma|Aplastic Anemia|Multiple Myeloma|Myelodysplastic Syndrome
Interventions: DRUG: Busulfan|DRUG: Clofarabine|DRUG: Fludarabine|DRUG: Melphalan|DRUG: Carmustine|DRUG: Etoposide|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cryoanalgesia Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain, Postoperative
Interventions: DEVICE: cryoICE® system (AtriCure, Inc) with CryoSphere (CryoS) probe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Vitamin D and Marine Omega-3 Fatty Acids on Anemia
Status: UNKNOWN
Conditions: Anemia
Interventions: DIETARY_SUPPLEMENT: Vitamin D3 .|DRUG: omega-3 fatty acids (fish oil)|DIETARY_SUPPLEMENT: Vitamin D3 placebo|DIETARY_SUPPLEMENT: Fish oil placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Pharmacokinetics of Zidovudine and Oxazepam Alone and in Combination in the HIV-Infected Patient
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Oxazepam|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT