pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pioglitazone as an Adjunct for Moderate to Severe Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Pioglitazone+Citalopram+Chlordiazepoxide|DRUG: Placebo+ Citalopram+ Chlordiazepoxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: International Post Market Surveillance Study of Intracranial Aneurysms Treated With an Endovascular Approach
Status: ACTIVE_NOT_RECRUITING
Conditions: Intracranial Aneurysm
Interventions: DEVICE: Endovascular treatment of intracranial aneurysms using a flow-diverting stent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sedation Efficacy and Safety of Remifentanil in Ventilated Surgical Critically Ill Patients
Status: NOT_YET_RECRUITING
Conditions: Effect of Drug|Adverse Drug Event|Mechanical Ventilation Complication|Critical Illness|Surgery|Sedation
Interventions: DRUG: sedation drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Laser Optoacoustic and Ultrasonic Imaging System Assembly in Finding Changes in Tumors in Patients With Breast Cancer
Status: TERMINATED
Conditions: Breast Neoplasm|Inflammatory Breast Carcinoma
Interventions: PROCEDURE: Photoacoustic Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neoadjuvant Therapy of Abiraterone Plus ADT for High Risk Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DRUG: Abiraterone Acetate|DRUG: Prednisone|DRUG: Goserelin 10.8 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anlotinib Combined With Penpulimab as Front-line Treatment in Advanced Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: anlotinib combined with penpulimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety and Tolerability of TE-8105 in Overweight/Obese Participants Without Diabetes
Status: RECRUITING
Conditions: Overweight and Obesity
Interventions: DRUG: TE-8105 SAD Cohort 1|DRUG: TE-8105 SAD Cohort 2|DRUG: TE-8105 SAD Cohort 3|DRUG: TE-8105 SAD Cohort 4|DRUG: TE-8105 SAD Cohort 5 (Adaptive cohort)|DRUG: TE-8105 MAD Cohort 1|DRUG: TE-8105 MAD Cohort 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: User Evaluation in Healthy Volunteers to Verify no Pelvic Floor Contraction is Stimulated When the Modified Neurotech Vital Device is Used Compared to the Neurotech Vital Device
Status: COMPLETED
Conditions: Contraction of Pelvic Floor Muscle Using EMS
Interventions: DEVICE: Modified Neurotech Vital Device|DEVICE: Neurotech Vital Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Omission of ALND in Breast Cancer Patients With Axillary pCR
Status: RECRUITING
Conditions: Axillary Lymph Node Dissection|Pathological Complete Response|Neoadjuvant Systemic Therapy|Breast Cancer|Axillary Lymph
Interventions: PROCEDURE: Stained region Lymph Node Biopsy (SrLNB)|RADIATION: Regional lymph node radiotherapy (RNI) including the axilla
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Analgesic Effects of Dexmedetomidine for Transversus Abdominis Plane Block
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Bupivacaine|DRUG: Dexmedetomidine|DRUG: serum physiologic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Orfiril Long 500 mg Prolonged-Release Minitablets and Ergenyl Chrono 500 mg Prolonged-Release Tablets
Status: COMPLETED
Conditions: Multiple Drug Use
Interventions: DRUG: Sodium valproate 500 MG|DRUG: Valproic Acid 500 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Paliperidone and Risperidone for Treatment of Patirnts With Methamphetamine-Associated Psychosis
Status: COMPLETED
Conditions: Methamphetamine Dependence
Interventions: DRUG: paliperidone|DRUG: Risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of RSD1235-SR for the Prevention of Atrial Fibrillation/Atrial Flutter Recurrence
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Vernakalant (oral)|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Study of Gemcitabine Plus Nab-Paclitaxel in Combination With Pegvorhyaluronidase Alfa (PVHA; PEGPH20) and Pembrolizumab as Front-line Treatment for Metastatic Pancreatic Adenocarcinoma.
Status: WITHDRAWN
Conditions: Pancreas Adenocarcinoma
Interventions: DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pazopanib for the Treatment of Epistaxis in Hereditary Hemorrhagic Telangiectasia
Status: NOT_YET_RECRUITING
Conditions: Hereditary Hemorrhagic Telangiectasia|Epistaxis
Interventions: DRUG: Pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Pharmacokinetic Effects of TQD3606 for Injection in Healthy Adult Subjects
Status: UNKNOWN
Conditions: Infections
Interventions: DRUG: The injectable TQD3606|DRUG: meropenem|DRUG: Avibactam Sodium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Sucralfate to Improve Oral Intake in Children With Infectious Oral Ulcers: a Randomized, Double-blind, Placebo-Controlled Trial
Status: COMPLETED
Conditions: Herpangina|Gingivostomatitis|Hand, Foot and Mouth Disease
Interventions: DRUG: Sucralfate|OTHER: Placebo|DRUG: Acetaminophen|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Adult HMO Supplementation and the Gut Microbiome
Status: NOT_YET_RECRUITING
Conditions: Healthy Adults
Interventions: DIETARY_SUPPLEMENT: SuperHMO|DIETARY_SUPPLEMENT: Non-GMO corn Maltodextrin, Rapid Absorption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reducing Ethnic Health Disparities: Motivating HIV+ Latinos to Quit Smoking
Status: COMPLETED
Conditions: Tobacco Dependence|HIV Infections
Interventions: BEHAVIORAL: Standard Care Intervention (SCI)|BEHAVIORAL: Culturally Tailored Intervention (CTI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peristomal Skin Complications and Quality of Life
Status: COMPLETED
Conditions: Colorectal Cancer|Quality of Life|Stoma Ileostomy|Stoma Colostomy|Complication
Interventions: OTHER: STANDARD STOMA CARE AND COMPLICATION DIAGNOSTIC ALGORITHM EDUCATION|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating Etanercept in Subjects With Ankylosing Spondylitis in Spain
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: DRUG: etanercept|DRUG: etanercept/placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Oxygen Therapy for Mild Cognitive Impairment
Status: UNKNOWN
Conditions: Mild Cognitive Impairment and Vascular Subcortical Ischemia
Interventions: DEVICE: Hyperbaric oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Plasma Concentration of Tolebrutinib Given as a Tablet to Adult Participants With Renal Impairment Compared to Healthy Participants
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: tolebrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weight Loss Interventions in Obese Patients With Stages 3-4 Chronic Kidney Disease: a Randomised Controlled Trial
Status: COMPLETED
Conditions: Chronic Kidney Disease|Obesity
Interventions: PROCEDURE: laparoscopic sleeve gastrectomy|BEHAVIORAL: weight management program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes in Patients and Their Closest Relatives Treated for Congenital Heart Disease With Catheter Based or Surgical Techniques
Status: UNKNOWN
Conditions: Congenital Heart Defects
Interventions: PROCEDURE: Percutaneous pulmonary valve implantation or open heart surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study Evaluating Neratinib (HKI-272) In Combination With Vinorelbine In Subjects With Solid Tumors And Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Advanced Malignant Solid Tumors
Interventions: DRUG: neratinib|DRUG: vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ulipristal vs. GnRHa Prior to Laparoscopic Myomectomy
Status: UNKNOWN
Conditions: Fibroids
Interventions: DRUG: GnRHa|DRUG: Ulipristal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Local Anesthetic Infusion Pump Versus Depofoam Bupivacaine for Pain Management
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Depobupivacaine|DRUG: OnQ pump|DRUG: 0.25% Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Fluids in Benign Headaches Trial
Status: COMPLETED
Conditions: Headache
Interventions: DRUG: Normal Saline 5mL|DRUG: Normal Saline 20mL/kg|DRUG: Prochlorperazine 0.15 mg/kg up to 10 mg IV|DRUG: Diphenhydramine 1 mg/kg up to 50 mg IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Varicocelectomy: Can Sex-hormones Predict Improvements in Semen Quality?
Status: TERMINATED
Conditions: Varicocele|Infertility|Semen Quality
Interventions: PROCEDURE: Hormone and semen measurements before varicocelectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of rTMS and tDCS Combined With Robotic Rehabilitation In Patients With Spinal Cord Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Spinal Cord Disorder
Interventions: OTHER: active rTMS|OTHER: sham rTMS|OTHER: active tDCS|OTHER: sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Raltitrexed Concurrent With Radiotherapy for Elderly Chinese Patients With Squamous Cell Carcinoma of Esophagus
Status: UNKNOWN
Conditions: Esophagus Squamous Cell Carcinoma
Interventions: DRUG: raltitrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iliac Artery Treatment With The Invatec Scuba™ Cobalt Chromium Stent (INTENSE)
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: DEVICE: Scuba Iliac Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Uterus Transplantation From Live Donors and From Deceased Donors - Clinical Study
Status: RECRUITING
Conditions: Mayer Rokitansky Kuster Hauser Syndrome|Mullerian Aplasia|Uterus; Absence, Congenital|Infertility, Female|Uterus Absence, Acquired|Absolute Uterine Factor Infertility
Interventions: PROCEDURE: Live donor uterus transplantation|PROCEDURE: Deceased donor uterus transplantation|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Totally Robotic Versus Surgeon-Assisted Robotic Lung Resection For Early-Stage NSCLC
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer
Interventions: DEVICE: Medtronic Signia Stapler|DEVICE: Vessel Sealer Extend Energy Device and SureForm Stapler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pathological Myeloid Activation After Sepsis and Trauma
Status: RECRUITING
Conditions: Trauma Injury|Sepsis|Immunosuppression|Chronic Critical Illness
Interventions: OTHER: Data Collection|PROCEDURE: Bone marrow collection and blood collection|OTHER: Serial interviews to complete surveys and questionnaires|OTHER: Telephone follow up call
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Augmented Reality (AR): The Future of "Patient Information Leaflets
Status: UNKNOWN
Conditions: Sarcoma|Breast Cancer|Cleft Lip and Palate|Surgical Flap
Interventions: OTHER: Augmented Reality|OTHER: Traditional leaflet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Stereotactic Body Radiation Therapy for the Safety and Prognosis of Small Intrahepatic Recurrent HCC
Status: RECRUITING
Conditions: Carcinoma; Hepatocellular
Interventions: RADIATION: Stereotactic body radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug Interaction Study of Cyclosporine and LY3502970 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Midazolam|DRUG: LY3502970|DRUG: Cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Nebivolol (Added to Lisinopril or Losartan) in Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: nebivolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lateral Prostate Capsule Sparing Versus Non Nerve Sparing Robot-assisted Radical Cystectomy-orthotopic Ileal Neobladder for Bladder Cancer in the Male
Status: UNKNOWN
Conditions: Bladder Cancer
Interventions: PROCEDURE: lateral prostate capsule sparing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multiple Myeloma Outcomes Based on Maintenance Therapy Post Autologous Stem Cell Transplant
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: OTHER: Autologous Stem Cell Transplant|DRUG: Immunomodulatory Agent|DRUG: Proteasome Inhibitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Tolerability, and Clinical Activity of ASM-024 Administered to Patients With GOLD 2 or GOLD 3 Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: ASM-024|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy and Safety of Venetoclax in Combination With 3 Days Decitabine (DEC3-VEN) vs. Venetoclax in Combination With Azacitidine (VIALE-A) in the Treatment of Elderly Patients or Unfit, New-diagnosis Acute Myeloid Leukemia Patients
Status: NOT_YET_RECRUITING
Conditions: Elderly AML Patients|Unfit, New-diagnosis AML|Acute Myeloid Leukemia|Venetoclax|Decitabine
Interventions: PROCEDURE: Experimental: Venetoclax in combination with Decitabine (+-sorafenib)|PROCEDURE: Active Comparator: Standard dose of Venetoclax + Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Crizotinib in the Neoadjuvant Setting in Patients With Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer, Nonsmall Cell
Interventions: DRUG: Crizotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Non-Invasive Neuromodulation Device for Prevention of Episodic Migraine Headache
Status: TERMINATED
Conditions: Intervention
Interventions: DEVICE: active neuromodulation for episodic migraine headache|DEVICE: placebo neuromodulation for episodic migraine headache
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 3D Printing for the Fabrication of Mandibular Implant Overdentures
Status: NOT_YET_RECRUITING
Conditions: Edentulous Mouth|Edentulous Jaw
Interventions: OTHER: mandibular implant-overdenture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Coeliac Plexus Alcohol Neurolysis Along With Frey's Procedure for a Better Pain Relief
Status: UNKNOWN
Conditions: Chronic Calcific Pancreatitis
Interventions: PROCEDURE: celiac plexus neurolysis using absolute alcohol|PROCEDURE: Placebo celiac plexus injection using saline|PROCEDURE: Frey's procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Eszopiclone in Subjects With Insomnia Related to Major Depressive Disorder
Status: COMPLETED
Conditions: Insomnia|Depressive Disorder, Major
Interventions: DRUG: Eszopiclone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of BMF-219, a Covalent Menin Inhibitor, in Adult Patients With AML, ALL (With KMT2A/ MLL1r, NPM1 Mutations), DLBCL, MM, and CLL/SLL
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Acute Mixed-Phenotype Leukemia|Cancer|Refractory|Progression|Diffuse Large B Cell Lymphoma|Multiple Myeloma|Lymphoma|Lymphoma, Non-Hodgkin|Myeloma, Plasma-Cell|Myelomatosis|Plasma Cell Myeloma|Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: BMF-219
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab in Combination With GDP/ L-asparaginase in NK/ T-cell Lymphoma
Status: WITHDRAWN
Conditions: NK/T Cell Lymphoma
Interventions: DRUG: IV Nivolumab|DRUG: IV Nivolumab|DRUG: IV Gemcitabine|DRUG: IV Cisplatin|DRUG: IV/PO Dexamethasone|DRUG: IV L-asparaginase
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Ultrasound Guided PICC Line Insertion in Neonates With Standard Procedure
Status: COMPLETED
Conditions: Ultrasonography, Interventional|Peripheral Venous Catheterization
Interventions: PROCEDURE: Ultrasound guidance for PICC line placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetic Study in Children and Adolescents Aged 6 to 17 Years Who Have Been Diagnosed With ADHD
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: DRUG: SHP465 12.5mg|DRUG: SHP465 25mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor Stem Cell Transplant After Conditioning Therapy in Treating Patients With Hematologic Cancer, Recurrent or Metastatic Solid Tumor, or Other Disease
Status: COMPLETED
Conditions: Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Nonmalignant Neoplasm|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: anti-thymocyte globulin|DRUG: busulfan|DRUG: cyclosporine|DRUG: fludarabine phosphate|DRUG: methotrexate|DRUG: methylprednisolone|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Novel Closed-loop Integrated System for the Maintenance of Haemodynamic Stability
Status: COMPLETED
Conditions: Hypotension
Interventions: DEVICE: vasopressor delivery automated system|DRUG: phenylephrine|DRUG: ephedrine|DEVICE: manual vasopressor delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase Ib/IIa Dose Escalation and Expansion Study of [²¹²Pb]Pb-ADVC001 in Metastatic Castration Resistant Prostate Cancer (TheraPb - Phase I/II Study).
Status: RECRUITING
Conditions: Prostate Cancer|Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: [²¹²Pb]Pb-ADVC001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zimmer POLAR - Total Knee Arthroplasty (TKA)
Status: COMPLETED
Conditions: Osteoarthritis|RheumatoId Arthritis|Traumatic Arthritis|Polyarthritis
Interventions: DEVICE: Zimmer Persona Total Knee System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Rituximab in Combination With Methotrexate Compared to Methotrexate Alone in Patients With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Folate|DRUG: Methotrexate|DRUG: Methylprednisolone|DRUG: Placebo|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CD4+ T Cells and S100A7 Epression in Normal and Psoriatic Skin: A Histological and Histochemical Study
Status: NOT_YET_RECRUITING
Conditions: Psoriasis
Interventions: DIAGNOSTIC_TEST: skin biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Developing mHealth to Promote PrEP Use Among Thai Young Men Who Have Sex With Men
Status: RECRUITING
Conditions: Pre-Exposure Prophylaxis
Interventions: BEHAVIORAL: Motivational Enhancement System for PrEP Uptake and Adherence (MES-PrEP)|BEHAVIORAL: Motivational Interactive Text Messaging (MTM)|BEHAVIORAL: Standard PrEP Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of HQ® Matrix Medical Wound Dressing for Healing of Donor Site Wounds
Status: COMPLETED
Conditions: Donor Site Wound
Interventions: DEVICE: HQ® Matrix Medical Wound Dressing|DEVICE: Sidaiyi® wound dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: "E4/DRSP Endocrine Function, Metabolic Control and Hemostasis Study"
Status: COMPLETED
Conditions: Contraception|Liver Metabolism|Hemostasis Parameter
Interventions: DRUG: 15 mg E4/3 mg DRSP|DRUG: 30 mcg EE/150 mcg LNG|DRUG: 20 mcg EE/3 mg DRSP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparative Study of Aripiprazole, Quetiapine and Ziprasidone in Treatment of First Episode Psychosis: 3-year Follow-up
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders
Interventions: DRUG: Aripiprazole|DRUG: Quetiapine|DRUG: Ziprasidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of INCB013739 Plus Metformin Compared to Metformin Alone on Glycemic Control in Type 2 Diabetics
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: INCB013739|DRUG: INCB013739|DRUG: INCB013739|DRUG: INCB013739|DRUG: INCB013739|DRUG: Placebo comparator matching INCB013739|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic IABP in High-risk Patients Undergoing CABG
Status: WITHDRAWN
Conditions: Myocardial Infarction|Coronary Artery Disease
Interventions: PROCEDURE: Preoperative IABC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Clinical Study on the Application of the Third Space in the Operation of Gastric Submucosal Tumor
Status: UNKNOWN
Conditions: Gastric Submucosal Tumors
Interventions: PROCEDURE: Laparoscopy endoscopy cooperated surgery|PROCEDURE: Dan Vinchi robot endoscopy cooperated surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Proinflammatory Signaling in Alcohol Craving
Status: TERMINATED
Conditions: Alcohol Dependence|Alcohol Drinking|Stress|Alcohol-Related Disorders
Interventions: DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Compare Two Anti-Scorpion Venom Serum In Children
Status: COMPLETED
Conditions: Scorpion Sting
Interventions: BIOLOGICAL: Anti-scorpion venom serum Birmex|BIOLOGICAL: Anti-scorpion venom serum Alacramyn
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Parsaclisib in Patients With Relapsed or Refractory Follicular Lymphoma
Status: WITHDRAWN
Conditions: Follicular Lymphoma
Interventions: DRUG: lenalidomide|DRUG: rituximab|DRUG: parsaclisib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Psychological and Social Factors That May Increase the Risk of Developing Chronic Pain After Surgery in Women With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Pain|Psychosocial Effects of Cancer and Its Treatment
Interventions: OTHER: questionnaire administration|PROCEDURE: management of therapy complications|PROCEDURE: psychosocial assessment and care|PROCEDURE: quality-of-life assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: H3.3K27M Peptide Vaccine With Nivolumab for Children With Newly Diagnosed DIPG and Other Gliomas
Status: COMPLETED
Conditions: Diffuse Intrinsic Pontine Glioma|Glioma|Diffuse Midline Glioma, H3 K27M-Mutant
Interventions: BIOLOGICAL: K27M peptide|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Magnetic Resonance Imaging Hysterosalpingography for the Integral Evaluation of the Infertile Patient."
Status: UNKNOWN
Conditions: Women Infertility
Interventions: RADIATION: TC Virtual Hysterosalpingography|OTHER: MRI Virtual Hysterosalpingography|OTHER: Antimullerian Hormone dosing|OTHER: Transvaginal Echography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Comparison Between Two Types of Sealers in the Healing of Periapical Lesions
Status: COMPLETED
Conditions: Periapical Lesions
Interventions: PROCEDURE: Root canal treatment with AH Plus sealer|PROCEDURE: Root canal treatment with BioCeramic sealer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection of Plasmatic Cell-free BRAF and NRAS Mutations : a New Tool for Monitoring Patients With Metastatic Malignant Melanoma Treated With Targeted Therapies or Immunotherapy ( MALT )
Status: UNKNOWN
Conditions: Malignant Melanoma Stage IV|Malignant Melanoma Stage III
Interventions: BIOLOGICAL: quantification of BRAF and NRAS mutation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Study to Investigate the Pharmacokinetics of Multiple Repeated Doses of Intranasal Naloxone
Status: COMPLETED
Conditions: Healthy Subjects|Opioid Antagonist|Pharmacokinetics
Interventions: DRUG: Four naloxone nasal spray doses (1 every 2.5 min)|DRUG: Four naloxone nasal spray doses (2 every 2.5 min)|DRUG: Two naloxone nasal spray doses (1 every 2.5 min)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease
Status: RECRUITING
Conditions: Heterozygous Familial Hypercholesterolemia|Premature Coronary Heart Disease
Interventions: DRUG: VERVE-102
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Maternal Stress to Improve Obesity-related Parenting Practices
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity, Childhood
Interventions: BEHAVIORAL: CCC|BEHAVIORAL: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Furmonertinib Combined With Anlotinib as the First-line Treatment in Patients With EGFR Mutation-positive NSCLC
Status: RECRUITING
Conditions: Non-Small-Cell Lung Cancer
Interventions: DRUG: Furmonertinib|DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lidocaine and Ketamine Versus Standard Care on Acute and Chronic Pain
Status: TERMINATED
Conditions: Pain|Nausea
Interventions: DRUG: ropivacaine|DRUG: Lidocaine/Ketamine|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Distal Radius Steroid
Status: TERMINATED
Conditions: Fractures, Bone|Fractures, Closed|Radius Fracture Distal
Interventions: DRUG: Dexamethasone|DRUG: Methylprednisolone|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Tai Chi and Pulmonary Rehabilitation on the Effect of Indacaterol in Treatment naïve COPD Participants
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Tai-chi plus Indacaterol|OTHER: Pulmonary rehabilitation plus Indacaterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Education, Immigration and HPV Vaccination: an Informational Randomized Trial
Status: UNKNOWN
Conditions: Cervical Cancer|Vulvar Cancer|Anus Cancer|Penis Cancer|Mouse Papilloma|Head Cancer|Genital Wart|Neck Cancer
Interventions: BEHAVIORAL: Information T1|BEHAVIORAL: Information T2|BEHAVIORAL: Information C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Nutrition Supplementation in Hospitalized Patients
Status: COMPLETED
Conditions: Malnutrition
Interventions: DRUG: Amino Acids w/Electrolytes in Dextrose|DIETARY_SUPPLEMENT: Ensure product|DRUG: Crystalloid solutions|DIETARY_SUPPLEMENT: Oral nutritional supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RHEIA (Randomized researcH in womEn All Comers With Aortic Stenosis)
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Valve Stenosis|Heart Valve Diseases
Interventions: PROCEDURE: Transcatheter aortic valve replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Early Hydration in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Contrast Induced Acute Kidney Injury
Interventions: DRUG: sodium bicarbonate solution|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Pivotal Study to Assess the Effectiveness of Nasal Dilator (Breathe Right Nasal Strips)
Status: COMPLETED
Conditions: Congestion, Nasal
Interventions: DEVICE: Breathe Right Tan (small/medium) nasal strips|OTHER: Placebo nasal strip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Methadone for Pediatric Tonsillectomy Pain
Status: NOT_YET_RECRUITING
Conditions: Pain, Postoperative|Tonsillar Hypertrophy|Tonsillitis|Pediatric Sleep Apnea|Sleep-Disordered Breathing
Interventions: DRUG: Methadone|DRUG: Fentanyl/Hydromorphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mid-point to Pleura Transverse Process Block Versus Thoracic Intervertebral Foramen Block
Status: RECRUITING
Conditions: Pain, Acute|Rib Fractures|Polytrauma
Interventions: PROCEDURE: Thoracic intervertebral foramen block|PROCEDURE: Mid-point to pleura transverse process block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Order Spectral Analysis of Local Field Potential Data on a Subgroup of Parkinson's Disease Patients Who Are Carriers of Mutations in the Glucocerebrosidase (GBA) Gene Undergoing DBS Electrode Placement
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: collection of LFPs
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: EASEGO Study: Doubling of Atorvastatin/Simvastatin or INEGY in Patients With Hypercholesterolemia and Coronary Artery Disease(CAD)(0653A-089)
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DRUG: ezetimibe (+) simvastatin|DRUG: simvastatin|DRUG: atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identifying, Understanding, and Overcoming Barriers to the Use of Clinical Practice Guidelines in Pediatric Oncology
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|B-Cell Non-Hodgkin Lymphoma|Childhood Acute Myeloid Leukemia|Childhood Burkitt Lymphoma|Childhood Neoplasm|Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm|Recurrent Childhood Acute Lymphoblastic Leukemia
Interventions: OTHER: Informational Intervention|OTHER: Interview|OTHER: Medical Chart Review|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sapphire II PRO US Clinical Study
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Disease|Myocardial Ischemia|Heart Diseases|Arteriosclerosis|Cardiovascular Diseases
Interventions: DEVICE: Sapphire II PRO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LINX Reflux Management System in Subjects With GERD Who Have Previously Undergone a Laparoscopic Sleeve Gastrectomy
Status: COMPLETED
Conditions: GERD|Gastroesophageal Reflux Disease
Interventions: DEVICE: LINX device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Late Surfactant to Prevent BPD: A Pilot Study in Ventilated Preterm Neonates Receiving Inhaled Nitric Oxide
Status: COMPLETED
Conditions: Respiratory Distress Syndrome of Prematurity (Surfactant Dysfunction)|Bronchopulmonary Dysplasia
Interventions: DRUG: Infasurf (ONY Inc.)|DRUG: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rintatolimod and Pembrolizumab for the Treatment of Refractory Metastatic or Unresectable Colorectal Cancer
Status: WITHDRAWN
Conditions: Metastatic Colorectal Adenocarcinoma|Microsatellite Stable|Mismatch Repair Proficient|Refractory Colorectal Adenocarcinoma|Stage III Colorectal Cancer AJCC v8|Stage IIIA Colorectal Cancer AJCC v8|Stage IIIB Colorectal Cancer AJCC v8|Stage IIIC Colorectal Cancer AJCC v8|Stage IV Colorectal Cancer AJCC v8|Stage IVA Colorectal Cancer AJCC v8|Stage IVB Colorectal Cancer AJCC v8|Stage IVC Colorectal Cancer AJCC v8|Unresectable Colorectal Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab|OTHER: Questionnaire Administration|DRUG: Rintatolimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Telerehabilitation on Subacromial Pain Syndrome
Status: COMPLETED
Conditions: Subacromial Pain Syndrome
Interventions: OTHER: Home Exercise Group|OTHER: Manual Therapy Group|OTHER: Telerehabilitation Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Visual Acuity in Patients With Polypoidal Choroidal Vasculopathy and Aflibercept Treatment
Status: COMPLETED
Conditions: Polypoidal Choroidal Vasculopathy
Interventions: DRUG: Intravitreal aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate Pharmacokinetics of Daewon DW-ES(A) 625mg/5ml, Daewon DW-ES(B) 625mg/5ml and Megace 800mg/20ml in Healthy Male Volunteers Under Fed Condition
Status: UNKNOWN
Conditions: Healthy Volunteers
Interventions: DRUG: megace|DRUG: DW-ES(A)|DRUG: DW-ES(B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Phase I Study of SB-480848(Darapladib) -Repeat Dose Study in Healthy Japanese Male Subjects-
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DRUG: SB-480848 (Darapladib)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Exercise and Nutrition Interventions in Age-related Sarcopenia
Status: UNKNOWN
Conditions: Sarcopenia|Muscular Atrophy
Interventions: DIETARY_SUPPLEMENT: Protein Supplementation|OTHER: Aerobic Exercise|OTHER: Resistance Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Epigallocatechin Gallate Lowers Circulating Catecholamine Concentrations and Alters Lipid Metabolism.
Status: COMPLETED
Conditions: EGCG Influence on Catecholamine Metabolism
Interventions: DIETARY_SUPPLEMENT: Epigallocatechin gallate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Geotropic Horizontal Canal Benign Paroxysmal Positional Vertigo
Status: COMPLETED
Conditions: Benign Paroxysmal Positional Vertigo
Interventions: PROCEDURE: Gufoni|PROCEDURE: Sham|PROCEDURE: Barbecue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PREoxygenation for the Intubation of Hypoxemic Patients: Comparison of Standard Oxygenation, High Flow Nasal Oxygen Therapy, and NonInvasive Ventilation
Status: UNKNOWN
Conditions: Adult Patients|Requiring Intubation|Hypoxemia (Defined by PaO2/FiO2( Fraction of Inspired Oxygen) Below 200)|Patient Covered by French Health Care System
Interventions: PROCEDURE: - standard oxygenation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous CD19 CAR-T Cell Therapy (SYNCAR-001) + Orthogonal IL-2 (STK-009) in Subjects With Severe, Refractory Systemic Lupus Erythematosus
Status: NOT_YET_RECRUITING
Conditions: Systemic Lupus Erythematosus|Lupus Nephritis
Interventions: DRUG: SYNCAR-001|DRUG: STK-009
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AMHR2 Polymorphism in Blood and Granulosa Cells in Unexplained Infertility
Status: RECRUITING
Conditions: Infertility, Female|AMH|IVF
Interventions: GENETIC: AMHR2 polymorphism in blood|GENETIC: AMHR2 polymorphism in granulosa cell
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pilot Clinical Trial of Pyruvate, Creatine, and Niacinamide in Progressive Supranuclear Palsy.
Status: COMPLETED
Conditions: Progressive Supranuclear Palsy
Interventions: DIETARY_SUPPLEMENT: Pyruvate, creatine, niacinamide|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transanal Versus Laparoscopic Total Mesorectal Excision for Rectal Cancer
Status: WITHDRAWN
Conditions: Rectal Cancer
Interventions: PROCEDURE: Transanal total mesorectal excision|PROCEDURE: Laparoscopic total mesorectal excision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects and Safety of Different Dose of Bambuterol on Chinese COPD Patients
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: bambuterol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virgin Coconut Oil (VCO) as a Potential Adjuvant Therapy in COVID-19 Patients
Status: UNKNOWN
Conditions: Coronavirus Infections
Interventions: DRUG: virgin coconut oil (VCO)|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Dose-Ranging Trial of Inhaled Cannabis for Acute Migraine Treatment
Status: SUSPENDED
Conditions: Migraine|Cannabis|THC
Interventions: DRUG: THC ~2.5%|DRUG: THC ~5%|DRUG: THC ~10%|DRUG: Sham Cannabis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeting EGFR/ERBB2 With Neratinib in Hormone Receptor (HR)-Positive/HER2-negative HER2-enriched Advanced/Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Neratinib + endocrine therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LUPUS-BEST - Treat-to-target in Systemic Lupus Erythematosus
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: OTHER: Treat-to-target as a new treatment concept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Evaluating the Safety and Efficacy of Levamisole in Loa Loa Microfilaremic Patients
Status: COMPLETED
Conditions: Onchocerciasis, Ocular|Loiasis
Interventions: DRUG: LEV 1 mg/kg|DRUG: LEV 1,5 mg/kg|DRUG: LEV 2,5 mg/kg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of Immunogenicity and Safety of Two Doses of MVA-nef vs. MVA-BN in HIV-1 Infected Patients
Status: COMPLETED
Conditions: HIV Infection
Interventions: BIOLOGICAL: MVA-nef|BIOLOGICAL: IMVAMUNE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Dexmedetomidine Combined With Low-dose Nalmefene on Preventing Remifentanil-induced Postoperative Hyperalgesia
Status: COMPLETED
Conditions: Pain|Anesthesia
Interventions: DRUG: Normal saline|DRUG: Remifentanil|DRUG: Sufentanil|DRUG: Dexmedetomidine injection|DRUG: Nalmefene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION