pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Carbon Dioxide Fractional Laser in Treating Participants With Stage 0-III Hormone Receptor-Positive Breast Cancer With Vulvovaginal Atrophy
Status: WITHDRAWN
Conditions: Anatomic Stage 0 Breast Cancer AJCC v8|Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Breast Adenocarcinoma|Dyspareunia|Estrogen Receptor Positive|Progesterone Receptor Positive|Prognostic Stage 0 Breast Cancer AJCC v8|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8|Vaginal Dryness|Vaginal Itching|Vulvovaginal Atrophy
Interventions: DEVICE: Carbon Dioxide Fractional Laser|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Etanercept (Enbrel®) in Psoriasis - Pediatrics
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Etanercept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Opioid-induced Bowel Dysfunction (OBD) Pivotal Assessment of Lubiprostone (OPAL)
Status: COMPLETED
Conditions: Opioid-induced Bowel Dysfunction
Interventions: DRUG: Lubiprostone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Correlation Between Dental Inclination and Bone Thickness in Patients With Class III Dentofacial Deformities
Status: COMPLETED
Conditions: Dentofacial Deformities
Interventions: PROCEDURE: orthodontic decompensation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Selatogrel Outcome Study in Suspected Acute Myocardial Infarction
Status: ENROLLING_BY_INVITATION
Conditions: Acute Myocardial Infarction
Interventions: COMBINATION_PRODUCT: Selatogrel|COMBINATION_PRODUCT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Derotation Banding on Outcome Measures in Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy, Spastic
Interventions: OTHER: Kinesio Taping|OTHER: Conventional Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Reverse Versus Anatomic Shoulder Arthroplasty Techniques in the Treatment of Osteoarthritis
Status: RECRUITING
Conditions: Shoulder Osteoarthritis
Interventions: PROCEDURE: Reverse Total Shoulder Arthroplasty (RTSA)|PROCEDURE: Total Shoulder Arthroplasty (TSA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Nivolumab Combined With Ipilimumab and Nivolumab Alone in Patients With Advanced or Metastatic Solid Tumors of High Tumor Mutational Burden (TMB-H)
Status: COMPLETED
Conditions: Pan Tumor
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Making PrEP Smart: An HIV Testing and PrEP Electronic Support Tool ("SmartPrEP" App) for Women on PrEP
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV/AIDS
Interventions: BEHAVIORAL: Making PrEP Smart
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Observational Patient Diary Study of Treatment Doses for Patients With Haemophilia With Inhibitors to Factors VIII and IX
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A With Inhibitors|Haemophilia B With Inhibitors
Interventions: DRUG: activated recombinant human factor VII|DRUG: Feiba VH
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Problem-Solving Training
Status: COMPLETED
Conditions: Child Development Disorders, Pervasive|Problems Psychosocial|Mother-Infant Interaction
Interventions: BEHAVIORAL: Problem-Solving Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery
Status: RECRUITING
Conditions: Injection|Non-cardiac Surgery|Delirium in Old Age|Post Operative Delirium
Interventions: DRUG: Sodium Chloride Injection|DRUG: Huperzine A Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: To Evaluate the Efficacy of DDB/Garlic Oil in Patients With Elevated Transaminase Chronic Liver Disease
Status: COMPLETED
Conditions: Chronic Liver Disease
Interventions: DRUG: Pennel|DRUG: Legalon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-Operative Pain Evaluation After Using Different Single-file Root Canal Preparation System: A Randomized Clinical Study
Status: COMPLETED
Conditions: Root Canal Treatment
Interventions: DEVICE: Hyflex EDM , The XP-endo Shaper, Primary WaveOne Gold
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Dexamethasone, Carfilzomib, & Nivolumab With Pelareorep for Relapsed/Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Recurrent Plasma Cell Myeloma
Interventions: DRUG: Carfilzomib|DRUG: Dexamethasone|BIOLOGICAL: Nivolumab|BIOLOGICAL: Pelareorep
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Efficacy and Safety of BOTOX® or Solifenacin in Patients With Overactive Bladder and Urinary Incontinence
Status: COMPLETED
Conditions: Overactive Bladder|Urinary Incontinence
Interventions: BIOLOGICAL: BOTOX®|DRUG: solifenacin|DRUG: Botox placebo (normal saline)|DRUG: solifenacin placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Gastric Inhibition of Two Proton Pump Inhibitors (CL2008-18)(P07815)(COMPLETED)
Status: COMPLETED
Conditions: Human Experimentation
Interventions: DRUG: Zegerid|DRUG: Prevacid®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Maraviroc on Endothelial Function in HIV-Infected Patients
Status: COMPLETED
Conditions: HIV Infection|Cardiovascular Disease|Inflammation|HIV Infections
Interventions: DRUG: Maraviroc|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glutamatergic Modulation to Facilitate the Behavioral Treatment of Cocaine Use Disorders
Status: SUSPENDED
Conditions: Cocaine Use Disorder
Interventions: DRUG: CI-581a|DRUG: CI-581b|BEHAVIORAL: Motivational Enhancement Therapy (MET)|BEHAVIORAL: Mindfulness Based Relapse Prevention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is Routine Cervical Dilatation Necessary During Elective Caesarean Section? A Randomised Controlled Trial
Status: UNKNOWN
Conditions: Failure of Cervical Dilatation|Complications; Cesarean Section|Wound Infection,|External Causes of Morbidity and Mortality
Interventions: PROCEDURE: cervix dilated after surgery|PROCEDURE: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Magnesium Sulfate in Thrombotic Thrombocytopenic Purpura in Intensive Care
Status: UNKNOWN
Conditions: Thrombotic Thrombocytopenic Purpura
Interventions: DRUG: Sulfate, Magnesium|DRUG: Placebo - Concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Group-Based Behavioral Therapy Combined With Stimulant Medication for Treating Children With Attention Deficit Hyperactivity Disorder and Impaired Mood
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: BEHAVIORAL: Group-based behavior therapy|DRUG: Stimulant medication therapy|BEHAVIORAL: Community-based psychosocial treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Determine Effects Of Fluticasone Propionate On Sputum Neutrophils After Inhaled Lipopolysaccharide Challenge In Volunteers
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Fluticasone Propionate|DRUG: Placebo for Fluticasone Propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Optimizing Growth in Infants Receiving Modified Fat Breast Milk for the Treatment of Chylothorax
Status: COMPLETED
Conditions: Chylothorax
Interventions: OTHER: Target Fortification|OTHER: Higher Initial Concentration|OTHER: Portagen Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Role of Lung Function for Exercise Capacity in Well-trained Individuals
Status: RECRUITING
Conditions: Exercise Performance
Interventions: DRUG: Vilanterol and Fluticasone Furoate|DRUG: Indacaterol and Mometasone Furoate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of the echOpen Device to Identify Effusion and to Detect Basilic Vein
Status: COMPLETED
Conditions: Pleural Effusion|Abdominal Effusion|Procedural Guidance
Interventions: DEVICE: EchOpen ultra-portable ultrasound device|DEVICE: Ultrasound device routinely used in the department.|PROCEDURE: Standard ultrasound examination by an independent referent radiologist
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Colon Staining Efficacy of Single Oral Doses of Methylene Blue MMX
Status: COMPLETED
Conditions: Colon Staining in Preparation for Colonoscopy
Interventions: DRUG: Methylene Blue MMX 25 mg modified release tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Stem Cell Transplant for Juvenile Myelomonocytic Leukemia (JMML)
Status: COMPLETED
Conditions: Juvenile Myelomonocytic Leukemia
Interventions: BIOLOGICAL: Stem Cell Transplant|DRUG: Preparative Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Infusion of Liposomal Amphotericin B in Indian Visceral Leishmaniasis
Status: COMPLETED
Conditions: Visceral Leishmaniasis
Interventions: DRUG: Liposomal Amphotericin B|DRUG: amphotericin B deoxycholate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn How the Study Treatment BAY2395840 Moves Into, Through and Out of the Body, How Safe it is, and How it Affects the Body in Participants With Moderate Reduced Kidney Function and in Healthy Male and Female Participants With Normal Kidney Function
Status: WITHDRAWN
Conditions: Diabetic Neuropathic Pain|Renal Impairment|Healthy Volunteers
Interventions: DRUG: BAY2395840
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of VistaO2 FLUX Device in Screening of Sleep Apnea/Hypopnea Syndrome
Status: TERMINATED
Conditions: Sleep Apnea Syndromes
Interventions: DEVICE: VistaO2 FLUX device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Characterization of the Molecular Mechanisms Involved in Delayed-Type Hypersensitivity Reactions to House Dust Mite, Diphencyprone, Nickel, and Tuberculin Purified Protein Derivative in Healthy Volunteers
Status: COMPLETED
Conditions: Delayed Type Hypersensitivity
Interventions: DRUG: Prednisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Implementation of the NPMS Obstetric Hemorrhage Bundle at a Tertiary Center: Utilization of the Delphi Method
Status: COMPLETED
Conditions: Pregnancy Hemorrhage|Postpartum Hemorrhage
Interventions: OTHER: Survey
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety Study of ACYW135 Meningococcal Polysaccharide Vaccine Aged 2-50 Years Old
Status: COMPLETED
Conditions: Meningococcal
Interventions: BIOLOGICAL: A dose of ACYW135 meningococcal polysaccharide vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Efficacy of Pain Bloc-R in Healthy Participants With Non-pathological Aches and Discomfort
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Pain Bloc-R|OTHER: Active Comparator - Acetaminophen|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Benefit of Augmented Reality Mirror Therapy in Addition to Conventional Management in Complex Regional Pain Syndrome of the Upper Extremity
Status: RECRUITING
Conditions: Complex Regional Pain Syndromes
Interventions: OTHER: Conventional therapy|OTHER: ARMT|OTHER: cortical reactivity|OTHER: Fluidity of movement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Administration of Follicle-stimulating Hormone (FSH) and Low Dose Human Chorionic Gonadotropin (hCG) for Oocyte Maturity While Decreasing hCG Exposure in In Vitro Fertilization (IVF) Cycles
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Low dose hCG plus FSH co-trigger|DRUG: Standard dose of hCG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Trial of Monthly Versus Bi-weekly Endoscopic Variceal Ligation for the Prevention of Esophageal Variceal Rebleeding
Status: UNKNOWN
Conditions: Esophageal and Gastric Varices
Interventions: PROCEDURE: monthly Endoscopic Variceal Ligation (EVL)|PROCEDURE: bi-weekly Endoscopic Variceal Ligation (EVL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Angiogenic Markers in Cerebrovascular Disease (ANFIS)
Status: ENROLLING_BY_INVITATION
Conditions: Stroke|Transient Ischemic Attack|Atherosclerosis|Intracranial Arterial Stenosis|Moyamoya
Interventions: OTHER: According to current clinical care standards
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessing Pharmacokinetics and Pharmacodynamics of Daily Enteric-coated Aspirin in Patients With StablE Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Aspirin 80 mg EC Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Stellate Block Versus Nimodipine Infusion for Traumatic Brain Injury
Status: UNKNOWN
Conditions: Traumatic Brain Injury
Interventions: PROCEDURE: ultrasound-guided stellate ganglion block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of ıntensified Sensory-based Therapy on Upper Extremity Functions and Activities of Daily Living
Status: COMPLETED
Conditions: Stroke|Sensory Defect
Interventions: OTHER: Occupational Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: cisplatin|DRUG: fenretinide|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Clinical Study Evaluating Nitric Oxide Nasal Spray (NONS) Efficacy To Treat and Prevent the Exacerbation of Infection in Individuals With Documented Asymptomatic or Mild COVID-19
Status: UNKNOWN
Conditions: Covid19
Interventions: DRUG: to be given as a treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improve PAD PERformance With METformin
Status: RECRUITING
Conditions: Peripheral Artery Disease
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesia Management in Bariatric Surgery
Status: COMPLETED
Conditions: Morbid Obesity|Bariatric Surgery Candidate|Pain|Postoperative
Interventions: DRUG: Lidocain|DRUG: Ketamine|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Atopic Dermatitis With Accelerometry and Polysomnography (ADAP)
Status: COMPLETED
Conditions: Atopic Dermatitis|Eczema|Healthy
Interventions: DEVICE: GENEActiv Accelerometry Device|DEVICE: Centrepoint Insights Watch (CPIW) Accelerometry Device|DEVICE: Apple Watch Accelerometry Device|DEVICE: Polysomnography|DEVICE: Videography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Milk Protein vs Blends of Milk and Plant Protein on Growth Markers in 7-8 Year Old Healthy Danish Children
Status: COMPLETED
Conditions: Growth Acceleration|Growth; Stunting, Nutritional
Interventions: DIETARY_SUPPLEMENT: 35 g protein (30% milk + 70% rapeseed)|DIETARY_SUPPLEMENT: 35 g protein (54% milk + 46% rapeseed)|DIETARY_SUPPLEMENT: 35 g protein (100% milk)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dexmedetomidine vs Propofol on the Recordings of Deep Brain Activity Measured Through Implanted Stimulators
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Dexmedetomidine|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Belinostat, Carboplatin and Paclitaxel (BelCaP) Compared to Carboplatin and Paclitaxel in Patients With Cancer of Unknown Primary
Status: COMPLETED
Conditions: Carcinoma of Unknown Primary
Interventions: DRUG: belinostat, carboplatin, paclitaxel|DRUG: carboplatin, paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: poStoperative Anesthesia Care: Facial Mask vs Hfnc and Thoracic Ultrasound for Reduction of Atelectasis Incidence
Status: COMPLETED
Conditions: Pulmonary Atelectasis|Postoperative Complications|Gynecologic Cancer|Anesthesia|Hypoxemia
Interventions: DEVICE: HFNC - Airvo 2|OTHER: Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real World Registry Assessing the Clinical Use of the Bard UltraScore Forced Focus PTA Balloon
Status: COMPLETED
Conditions: Peripheral Arterial Disease|Peripheral Vascular Diseases|Arterial Occlusive Diseases
Interventions: DEVICE: PTA (UltraScore Focused Force PTA Balloon)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use Repetitive Transcranial Magnetic Stimulation to Treat Somatic Symptom Disorder
Status: RECRUITING
Conditions: Somatic Symptom Disorder
Interventions: DEVICE: Repetitive transcranial magnetic stimulation|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors
Status: TERMINATED
Conditions: Brain and Central Nervous System Tumors|Carcinoma of Unknown Primary|Leukemia|Lymphoma|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Follow-Up Studies at Year 6, 7, 8, 9, 10: 2 Formulations of Combined Hepatitis A/B Vaccine Compared in Subjects Aged 12-15 Years
Status: COMPLETED
Conditions: Hepatitis B|Hepatitis A
Interventions: BIOLOGICAL: Twinrix™ Adult|BIOLOGICAL: Twinrix™ Junior
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Time of Effect Onset in Treating Overactive Bladder or Non Obstructive Urinary Retention by Sacral Neuromodulation
Status: COMPLETED
Conditions: Overactive Bladder|Non Obstructive Urinary Retention
Interventions: BEHAVIORAL: Filling out voiding diaries.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Pacemaker Lead Induced Tricuspid regurgitAtion by Transesophageal eCho guidEd Implantation (PLACE)
Status: RECRUITING
Conditions: Tricuspid Regurgitation|Pacemaker Complication
Interventions: PROCEDURE: Additional guidance of lead implantation by transesophageal echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Pharmacokinetics of the Combination Broadly Neutralizing Antibodies, 3BNC117-LS-J and 10-1074-LS-J, in Healthy American and African Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV-1-infection
Interventions: BIOLOGICAL: 3BNC117-LS-J|BIOLOGICAL: 10-1074-LS-J|BIOLOGICAL: Combination 3BNC117-LS-J and 10-1074-LS-J|BIOLOGICAL: Combination 3BNC117-LS-J and 10-1074-LS-J Ratio 1|BIOLOGICAL: Combination 3BNC117-LS-J and 10-1074-LS-J Ratio 2|BIOLOGICAL: Combination 3BNC117-LS-J and 10-1074-LS-J Ratio 3|BIOLOGICAL: Placebo|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: HAIC Combined With Anlotinib and TQB2450 as Adjuvant Therapy in HCC Patients With High Risk of Recurrence After Resection
Status: UNKNOWN
Conditions: Hepatocarcinoma
Interventions: DRUG: HAIC+TQB2450+Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of the Effect of Methylprednisolone Combined
Status: UNKNOWN
Conditions: Methylprednisolone;Dihydroxypropyltheophylline;One Lung Ventilation;Respiratory Dynamics
Interventions: DRUG: Methylprednisolone 40 MG Injection;Dihydroxypropyltheophylline;|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Colchicine in Patients Undergoing Coronary Artery Bypass Grafting After Acute Coronary Syndrome
Status: RECRUITING
Conditions: Coronary Artery Disease|Acute Coronary Syndrome|Coronary Artery Bypass|Myocardial Reperfusion|Postpericardiotomy Syndrome|Postoperative Atrial Fibrilation|Perioperative Myocardial Infarction
Interventions: DRUG: Colchicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Gut Microbiota-targeted Dietary Intervention Among HIV-infected Patients
Status: NOT_YET_RECRUITING
Conditions: Hiv|Cardiovascular Diseases|Diet, Healthy
Interventions: DIETARY_SUPPLEMENT: gut microbiota-targeted dietary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Branched-chain Amino Acid (BCAA) on the Progression of Primary Liver Cancer
Status: UNKNOWN
Conditions: Primary Liver Cancer
Interventions: DIETARY_SUPPLEMENT: Branched-chain amoni acids (BCAA)|DIETARY_SUPPLEMENT: non-BCAA protein supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Addition of Neostigmine to Levobupivacaine
Status: COMPLETED
Conditions: Spermatic Cord Block
Interventions: DRUG: Control Test|DRUG: Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optimal Intubating Technique Using Videolaryngoscopy in Patients With Semi-rigid Neck Collar
Status: COMPLETED
Conditions: Cervical Spine Surgery|Intubation;Difficult
Interventions: PROCEDURE: Sliding Intubating Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Phone Outreach Nudges Among Individuals Losing Medicaid Coverage
Status: ENROLLING_BY_INVITATION
Conditions: Behavioral Economics|Health Insurance
Interventions: BEHAVIORAL: Phone Outreach|BEHAVIORAL: Standard Notice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy Evaluation of the Mushroom Beverage on Emotion Regulation
Status: COMPLETED
Conditions: Inflammation, Brain|Emotional Problem
Interventions: DIETARY_SUPPLEMENT: beverage containing mushroom-extracts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety, Efficacy, and Tolerability of TEZ/IVA in Orkambi® (Lumacaftor/Ivacaftor) -Experienced Subjects With Cystic Fibrosis (CF)
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Tezacaftor/Ivacaftor|DRUG: Ivacaftor|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Profile of N-Acetyl Cysteine
Status: ACTIVE_NOT_RECRUITING
Conditions: Pharmacokinetics
Interventions: DIETARY_SUPPLEMENT: NAC|DIETARY_SUPPLEMENT: Neuro-NAC|DIETARY_SUPPLEMENT: Neuro-NAC XS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Onstep Versus Lichtenstein, the Onli Trial.
Status: COMPLETED
Conditions: Hernia, Inguinal|Chronic Pain
Interventions: PROCEDURE: Onstep|PROCEDURE: Lichtenstein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxytocin Via Intramuscular Injection and Intravenous Bolus or Infusion for Prevention of Postpartum Hemorrhage
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: First Time in Human Study (FTIH) With Positron Emission Tomography (PET)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: GSK1144814|DRUG: GSK1144814|DRUG: GSK1144814
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy of Osimertinib in Patients With EGFR-sensitive Mutated Non-small Cell Lung Cancer Progression After Receiving Adjuvant Targeted Therapy Following Radical Surgery
Status: NOT_YET_RECRUITING
Conditions: Lung Neoplasms|Lung Cancer, Nonsmall Cell
Interventions: DRUG: Osimertinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Darolutamide in Patients With Androgen Receptor-Positive Salivary Gland Carcinoma (DISCOVARY)
Status: ACTIVE_NOT_RECRUITING
Conditions: Salivary Gland Cancer
Interventions: DRUG: Darolutamide|DRUG: Goserelin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Restoration Quality in Molars Affected by Molar Incisor Hypo Mineralization
Status: UNKNOWN
Conditions: Molar Incisor Hypomineralization
Interventions: PROCEDURE: preformed stainless steel crowns cemented by glass ionomer luting cement(Ketac Cem, 3M Espe)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Behavioral Weight Loss Therapy for Obesity and Binge Eating in Monolingual Hispanic Persons
Status: COMPLETED
Conditions: Obesity|Binge Eating
Interventions: DRUG: Xenical + behavioral intervention|BEHAVIORAL: Behavioral intervention + placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Music Therapy to Address Patients' Journeys With Chronic Illness, Outcomes, and Readmission - MAJOR CHORD RCT
Status: NOT_YET_RECRUITING
Conditions: Heart Failure|Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: Music Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Chemotherapy Induced Peripheral Neuropathy (CIPN)
Status: COMPLETED
Conditions: Chemotherapy-induced Peripheral Neuropathy
Interventions: OTHER: Arm 1: Investigational INF|OTHER: Arm 2: standardized muscle stretching and strength
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Second-line Treatment With Apatinib for Advanced Intrahepatic Cholangiocarcinoma
Status: UNKNOWN
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heart Failure IDentification in a High Risk Cardiovascular OutpatiEnt Population (HIDE)
Status: COMPLETED
Conditions: Heart Failure
Interventions: DIAGNOSTIC_TEST: NYHA assessment|PROCEDURE: Serum NT-proBNP concentration|DIAGNOSTIC_TEST: Transthoracic Ecocardiogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: RC48 for Neoadjuvant Chemotherapy of HER2 Positive Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|HER2-positive Breast Cancer
Interventions: DRUG: Recombinant humanized anti-HER2 monoclonal antibody-MMAE coupling agent (RC48-ADC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BL-M02D1 in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer or Other Solid Tumors
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: BL-M02D1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation in Treating Immune-Checkpoint Inhibitor Induced-Diarrhea or Colitis in Genitourinary Cancer Patients
Status: RECRUITING
Conditions: Colitis|Diarrhea|Malignant Genitourinary System Neoplasm|Melanoma|Lung Cancer|Ovarian Cancer|Uterine Cancer|Breast Cancer|Cervical Cancer
Interventions: PROCEDURE: Fecal Microbiota Transplantation|DRUG: Loperamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contraction (Exercise) Mediated Glucose Uptake as a Therapeutic Target in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: nitroprusside, pentalong, imdur, AICAR, isoptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ocrelizumab Compared to Placebo in Patients With Active Rheumatoid Arthritis Continuing Methotrexate Treatment (STAGE)
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Methotrexate|DRUG: ocrelizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Long-term HFNC for COPD Patients With HOT
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DEVICE: High-flow nasal cannula therapy|DEVICE: Home oxygen therapy (HOT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erythritol vs Ultrasonic Scaler Prophylaxis Systems on Dental Implants With Crowns Made by Different Materials
Status: ENROLLING_BY_INVITATION
Conditions: Dental Implant Failed|Peri-implant Mucositis|Peri-Implantitis
Interventions: OTHER: Erythritol prophylactic powders|OTHER: Ultrasonic scaler with peek inserts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Patient Expectation in Dry Needling and Analgesia
Status: COMPLETED
Conditions: Neck Pain
Interventions: PROCEDURE: Dry needling with positives expectation|PROCEDURE: Dry needling with neutral expectation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mobile-phone-based Home Exercise in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Moderate to Severe COPD Receiving Home Exercise Training
Interventions: BEHAVIORAL: Mobile-phone-based Home Exercise Training Program|BEHAVIORAL: Home Exercise Training Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Morpho-functional Changes After Oral Supplementation of Antioxidants and Anti-inflammatory Treatment in Age-Related Macular Degeneration.
Status: COMPLETED
Conditions: Dry AMD
Interventions: OTHER: Macuprev Group|OTHER: Placebo Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Consistency, Immunogenicity, and Safety of Three Batches of 15-valent Pneumococcal Conjugate Vaccine
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: 15-valent pneumococcal conjugate vaccine 202210001|BIOLOGICAL: 15-valent pneumococcal conjugate vaccineY202210002|BIOLOGICAL: 15-valent pneumococcal conjugate vaccineY202210003|BIOLOGICAL: 15-valent pneumococcal conjugate vaccineY202210004|BIOLOGICAL: 13 valent pneumococcal polysaccharide conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Safety Study of Lactobacillus Reuteri BGP-014 in Patients With Ulcerative Colitis
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: BIOLOGICAL: BGP-014|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SCALE-UP Utah: Community-Academic Partnership to Address COVID-19 Vaccination Rates Among Utah Community Health Centers
Status: COMPLETED
Conditions: Covid19
Interventions: BEHAVIORAL: Text-Messaging (TM)|BEHAVIORAL: Patient Navigation (PN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Study Comparing Intramedullary Nailing, Plate Fixation, and Non-operative Treatment of Clavicle Fractures
Status: WITHDRAWN
Conditions: Clavicle Fractures
Interventions: OTHER: Non-operative Treatment|PROCEDURE: Operative Treatment-Plate Fixation|PROCEDURE: Operative Treatment-Intramedullary Pinning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Universal Capillary Screening for Chronic Autoimmune, Metabolic and Cardiovascular Diseases: Feasibility and Acceptability Pilot Study.
Status: COMPLETED
Conditions: Cardiovascular Risk Factors|Autoimmune Diseases
Interventions: OTHER: Screening test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: De-resuscitation Informed by Ultrasound for Patients With Sepsis
Status: UNKNOWN
Conditions: Sepsis|Septic Shock|Sepsis, Severe|Volume Overload
Interventions: DIAGNOSTIC_TEST: VExUS score
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transversus Thoracis Muscle Plane Block for Postoperative Pain in Adult Cardiac Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Chest Pain|Coronary Artery Bypass|Sternotomy
Interventions: PROCEDURE: Transversus Thoracic Muscle Plane Block|PROCEDURE: Parasternal Intercostal Plane Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Utilizing the HITSystem for Optimizing Paediatric ART Retention and Adherence in Western Nyanza Province, Kenya
Status: UNKNOWN
Conditions: Pediatric HIV Infection
Interventions: OTHER: HITSystem 3.0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Aerobic Training vs Balance Training on Fatigue Symptom in Multiple Sclerosis Patient (FATI-gate)
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: OTHER: Aerobic training|OTHER: Balance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Soft and Hard Tissue Healing and Implant Stability Of Hydrophilic Versus Conventional Titanium Dental Implants.
Status: NOT_YET_RECRUITING
Conditions: Dental Implants
Interventions: PROCEDURE: Dental Implant Surgery - Hydrophilic group|PROCEDURE: Dental Implant Surgery - Conventional group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A 12-Month Open Label Safety Study of Aptensio XR® in Children Ages 4-5 Years Diagnosed With ADHD
Status: UNKNOWN
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: Aptensio XR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Rising Dose Study to Assess Safety, Tolerability and Pharmacokinetics of BI 661051.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 661051|DRUG: BI 661051|DRUG: BI 661051|DRUG: BI 661051|DRUG: BI 661051|DRUG: BI 661051|DRUG: BI 661051|DRUG: BI 661051|DRUG: BI 661051|DRUG: Placebo|DRUG: BI 661051
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: A Clinical Study to Evaluate the Efficacy of Four Supplements on Improving Readiness for Intimacy
Status: ACTIVE_NOT_RECRUITING
Conditions: Libido|Intimacy|Gastrointestinal Issues
Interventions: DIETARY_SUPPLEMENT: Reset|DIETARY_SUPPLEMENT: Stay Ready Fiber|DIETARY_SUPPLEMENT: Libido|DIETARY_SUPPLEMENT: Testosterone supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bacillus Particles Prevent Children Antibiotics Associated Diarrhea
Status: UNKNOWN
Conditions: Antibiotic-associated Diarrhea
Interventions: DRUG: Bacillus licheniformis Intervention|OTHER: placebo Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Recombinant Human Antithrombin (ATryn®) in the Treatment of Patients With DIC Associated With Severe Sepsis
Status: TERMINATED
Conditions: Disseminated Intravascular Coagulation
Interventions: DRUG: Antithrombin alfa (INN name)|DRUG: Control (Standard treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preparing Older Adults for Major Surgery With Preoperative Comprehensive Geriatric Assessments
Status: ENROLLING_BY_INVITATION
Conditions: Surgery|Aging|Health Care Utilization|Frailty
Interventions: OTHER: Process Mapping: Observations|OTHER: Process Mapping: Interviews|OTHER: Process Mapping: Focus Group|OTHER: Participatory Design
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Efficacy and Safety Study of Long-Term Risperidone Microspheres in Participants With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Risperidone Long-Acting Injectable (RLAI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study for the Treatment of Adhesive Capsulitis of the Shoulder
Status: COMPLETED
Conditions: Adhesive Capsulitis|Frozen Shoulder
Interventions: BIOLOGICAL: Collagenase Clostridium Histolyticum|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ANCHOR (Aneurysm Treatment Using the Heli-FX™ EndoAnchor™ System Global Registry)
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Aneurysm
Interventions: DEVICE: EndoAnchor™|PROCEDURE: endovascular treament
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reconsolidation Blockade of Intrusive Trauma- and Cocaine-related Memories
Status: RECRUITING
Conditions: Post-traumatic Stress Disorder|Cocaine Use Disorder
Interventions: BEHAVIORAL: Imagery|DRUG: Minocycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Biofeedback-VR for Treatment of Chronic Migraine
Status: COMPLETED
Conditions: Chronic Migraine|Behavioral Treatment|Biofeedback|Virtual Reality|Medication Overuse Headache
Interventions: DEVICE: Combined biofeedback-virtual reality device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposome Bupivacaine for WRIST Blocks
Status: COMPLETED
Conditions: Dupuytren's Contracture of the Hand (Viking's Disease)
Interventions: DRUG: Liposome bupivacaine + bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Educational Program for Ostomy Patients (Ostomeducat)
Status: COMPLETED
Conditions: Educational Problems|Colostomy Complications|Surgery|Colorectal Disorders
Interventions: OTHER: Preoperative education|OTHER: Postoperative education
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE