pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Use of Esophageal String Test to Understand Symptoms, Inflammation, and Function in Eosinophilic Esophagitis
Status: COMPLETED
Conditions: Eosinophilic Esophagitis
Interventions: DEVICE: Esophageal String Test (EST)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intensive Combination Approach to Rollback the Epidemic in Nigerian Adolescents: UH3 Phase
Status: ACTIVE_NOT_RECRUITING
Conditions: Adolescent HIV Infection
Interventions: BEHAVIORAL: Peer navigation|BEHAVIORAL: SMS Text messaging|BEHAVIORAL: Social Media Engagement|BEHAVIORAL: Testing Peer Navigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Acupuncture for Women Victims of Domestic Violence With Psychiatric Sequelae
Status: RECRUITING
Conditions: Depression|Domestic Violence|Psychiatric Disorder
Interventions: PROCEDURE: Dense cranial electroacupuncture stimulation (DCEAS)|PROCEDURE: Transcutaneous electrical acupoint stimulation (TEAS)|OTHER: Wait-list control: Routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of a Bacteriophobic Coating on Urinary Catheters
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: DEVICE: Camstent Coated Catheter|DEVICE: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Short-term Basal Insulin Initiation in Newly Diagnosed Type 2 Diabetes on 1-year Glycemic Control
Status: RECRUITING
Conditions: Type2diabetes
Interventions: DRUG: Insulin Glargine 100 UNT/ML Pen Injector [Lantus]|DRUG: Saxagliptin 2.5 mg/ Metformin Hydrochloride extended release 1000 mg|DRUG: Pioglitazone 30mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tipifarnib and Etoposide in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Secondary Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: tipifarnib|DRUG: etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Near Infrared Technology and Laparoscopic Resection of Pancreatic Lesions: the COLPAN Project
Status: COMPLETED
Conditions: Pancreatic Neuroendocrine Tumors|Clear Cell Renal Carcinoma|Solid Pseudopapillary Tumors of the Pancreas
Interventions: DEVICE: NIR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase Ⅲ Randomized Study of Mitomycin/Vindesine/Cisplatin Versus Irinotecan/Carboplatin Versus Paclitaxel/Carboplatin With Concurrent Thoracic Radiotherapy for Unresectable Stage Ⅲ Non-Small-Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Cisplatin+Vindesine+MMC/ concurrent radiation|DRUG: Irinotecan+Carboplatin/concurrent radiation|DRUG: Paclitaxel+Carboplatin/concurrent radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dosage of Mepivacaine in Ultrasound Axillary Block
Status: COMPLETED
Conditions: Nerve Block|Neuromuscular Blockade|Anesthesia
Interventions: DRUG: Mepivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of RDX5791 for the Treatment of Constipation Predominant Irritable Bowel Syndrome (IBS-C)
Status: COMPLETED
Conditions: Constipation Predominant Irritable Bowel Syndrome
Interventions: DRUG: RDX5791
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Tablet Formulation and Food on PF-07104091 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Single dose of PF-07104091 as Tablet Formulation A (Treatment A)|DRUG: Single dose of PF-07104091 as Tablet Formulation B (Treatment B)|DRUG: Single dose of PF-07104091 as Tablet Formulation C (Treatment C)|DRUG: Single dose of PF-07104091 as Tablet Formulation D (Treatment D)|DRUG: Single dose of PF-07104091 as Tablet Formulation C (Treatment E)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Boosted Atazanavir (ATV) Versus Non-boosted ATV in Naive Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Atazanavir/ Stavidine / Lamivudine|DRUG: Atazanavir-Ritonavir/ Stavidine / Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Skeletal Muscle Adaptations to Traumatic Knee Injury and Surgery
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Reconstruction
Interventions: DEVICE: Neuromuscular electrical stimulation|DEVICE: Microstimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 3 Study of Nimotuzumab and Irinotecan as Second Line With Advanced or Recurrect Gastric and Gastroesophageal Junction Cancer
Status: TERMINATED
Conditions: Gastric Cancer|Gastroesophageal Junction Cancer
Interventions: DRUG: Irinotecan|DRUG: Nimotuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of 68Ga-GRP PET/CT for Imaging in Low and Intermediate Risk Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: 68Ga-PSMA PET/CT|DIAGNOSTIC_TEST: 68Ga-GRP PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Open-label Study to Compare Hospitalization Rates of Schizophrenic Patients Treated With Oral Antipsychotics Versus IM Depot Aripiprazole
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: Aripiprazole (Abilify®) IM Depot Injection|DRUG: Oral aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Using Fluorine-18-Labeled Fluoro-Misonidazole Positron Emission Tomography to Detect Hypoxia in Locally Advanced (T3-T4 and./or N1)Primary Rectal Cancer Patients
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: RADIATION: Fluorine-18-Labeled Fluoro-Misonidazole Positron Emission
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: GS-441524 for COVID-19 SAD, FE, and MAD Study in Healthy Subjects
Status: NOT_YET_RECRUITING
Conditions: COVID-19
Interventions: DRUG: GS-441524|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lornoxicam Versus Etodolac After Third Molar Surgery
Status: COMPLETED
Conditions: Pain, Acute|Edema|Trismus
Interventions: DRUG: Lornoxicam 8 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: RHINE™ Cervical Disc Clinical Study: A Prospective Observational Study for Patients Requiring 1-2 Level C-spine Surgery
Status: TERMINATED
Conditions: Radiculopathy|Myelopathy|Spondylosis|Herniated Nucleus Pulposus
Interventions: DEVICE: Rhine Cervical Disc
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pragmatic Cluster Randomized Controlled Trial to Standardize Attending Morning Rounds in Medicine
Status: COMPLETED
Conditions: Morning Rounds|Teaching Rounds|Hospitalization|Inpatients|Quality Improvement
Interventions: OTHER: Standardized attending morning rounds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Automated Versus Standard Physiotherapy for Upper Limb Rehabilitation in Patients With Acquired Brain Lesions
Status: WITHDRAWN
Conditions: Vascular Accident, Brain|Traumatic Brain Injury
Interventions: DEVICE: Armeo Spring|OTHER: conventional physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Home-based Exercise Rehabilitation on Healthcare Utilization in HeartMate 3 Patients
Status: COMPLETED
Conditions: Heart Failure|Left Ventricular Dysfunction
Interventions: BEHAVIORAL: Home-based Exercise Rehabilitation.|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NT-I7 (Efineptakin Alfa) in Combination With Pembrolizumab in Participants With Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Any Advanced Solid Tumors|Triple Negative Breast Cancer|Non Small Cell Lung Cancer|Small Cell Lung Cancer|Microsatellite Stable Colorectal Cancer|Pancreatic Cancer|Ovarian Cancer
Interventions: DRUG: NT-I7|DRUG: pembrolizumab (KEYTRUDA®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antenatal Betamethasone Compared to Dexamethasone - "BETACODE TRIAL"
Status: COMPLETED
Conditions: Respiratory Distress Syndrome|Intraventricular Hemorrhage|Neonatal Mortality
Interventions: DRUG: Betamethasone(Celestone soluspan) and Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Nurse-assisted Intervention "eHealth@ Hospital -2-home"
Status: RECRUITING
Conditions: Non Communicable Diseases|Heart Failure|Colon Rectal Cancer
Interventions: BEHAVIORAL: eHealth@Hospital-2-Home
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Curcumin Supplementation as an Add on Treatment for Patients With Inflammatory Bowel Diseases Treated With Vedolizumab
Status: UNKNOWN
Conditions: Inflammatory Bowel Diseases
Interventions: DIETARY_SUPPLEMENT: Curcumin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Muscle Energy Technique on Hamstring Muscle for Trigger Points of Muscle of Mastication
Status: RECRUITING
Conditions: Trigger Point Pain, Myofascial|Temporomandibular Disorder
Interventions: OTHER: Muscle Energy Technique|OTHER: Conventional PT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Subcutaneously Administered Tocilizumab in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: folic acid|DRUG: methotrexate|DRUG: tocilizumab [RoActemra/Actemra]|DRUG: tocilizumab [RoActemra/Actemra]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRF Versus Advanced PRF in Sinus Augmentation
Status: UNKNOWN
Conditions: Maxillary Sinus
Interventions: BIOLOGICAL: Advanced PRF|BIOLOGICAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Neovascular Age-Related Macular Degeneration (nAMD) (AAVIATE)
Status: RECRUITING
Conditions: Neovascular Age-Related Macular Degeneration (nAMD)
Interventions: BIOLOGICAL: Ranibizumab|GENETIC: RGX-314 Dose 1|GENETIC: RGX-314 Dose 2|GENETIC: RGX-314 Dose 3|DRUG: Local Steroid|DRUG: Topical Steroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Safety, Pharmacokinetics (PK) and Pharmacodynamics (PD) of BKM120 Plus GSK1120212 in Selected Advanced Solid Tumor Patients
Status: COMPLETED
Conditions: Advanced and Selected Solid Tumors
Interventions: DRUG: BKM120|DRUG: GSK1120212
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 0- Pilot Study of Pembrolizumab on Immune Cells in Patient With Refractory Acute Myeloid Leukemia
Status: WITHDRAWN
Conditions: Refractory Acute Myeloid Leukemia
Interventions: DRUG: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects on Liver Cirrhotic Patients' by a Nurse-led Clinic
Status: COMPLETED
Conditions: Liver Cirrhosis
Interventions: OTHER: risk factors|OTHER: self-care|OTHER: nutrition|OTHER: lifestyle|OTHER: psychosocial needs|OTHER: Nurse-led clinic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of E7777 Prior to Kymriah for R/R DLBCL
Status: RECRUITING
Conditions: DLBCL|Diffuse Large B Cell Lymphoma|High-grade B-cell Lymphoma|DLBCL Arising From Follicular Lymphoma
Interventions: DRUG: E7777
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Staccato Granisetron® (AZ 010) for the Treatment of Cyclic Vomiting Syndrome
Status: COMPLETED
Conditions: Cyclic Vomiting Syndrome
Interventions: COMBINATION_PRODUCT: 3mg AZ-010|COMBINATION_PRODUCT: 1mg AZ010|COMBINATION_PRODUCT: Staccato Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HDL-Atherosclerosis Treatment Study (HATS)
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Disease|Heart Diseases|Myocardial Ischemia
Interventions: DRUG: simvastatin|DRUG: niacin|DRUG: antioxidants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: |Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Orally Inhaled Aerosolized Hydroxychloroquine Sulfate in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Severe Acute Respiratory Syndrome Coronavirus 2
Interventions: DRUG: Aerolized Hydroxychloroquine Sulfate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Mulligans BLR and CR on Hamstrings Flexibility in Office Workers
Status: RECRUITING
Conditions: Muscle Tightness
Interventions: OTHER: Mulligan Bent Leg Raise technique|OTHER: PNF Contract Relax technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Creation of a Syncope Channel for Patients Admitted to the Emergency Department for Loss of Consciousness and Not Hospitalized: Etiological Predictivity (Before/After Study)
Status: RECRUITING
Conditions: Syncope
Interventions: DIAGNOSTIC_TEST: syncope channel|DIAGNOSTIC_TEST: routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of the Safety, Pharmacokinetic Drug Interaction and Efficacy of ETC-1002 and Atorvastatin in Subjects With Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: ETC-1002|DRUG: Placebo|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of BBT and Active Cycle of Breathing Technique on Dyspnea and Quality of Life in COPD
Status: RECRUITING
Conditions: COPD
Interventions: OTHER: Buyteko breathing technique|OTHER: active cycle of breathing technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Nebulized Beclomethasone Dipropionate (BDP) in the Treatment of Moderate Croup
Status: TERMINATED
Conditions: Croup
Interventions: DRUG: beclomethasone dipropionate suspension for nebulisation 800 mcg/2 ml|DRUG: Placebo solution for nebulisation 2 ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Focused Ultrasound (FUS) Mesencephalotomy for Head & Neck Cancer Pain
Status: RECRUITING
Conditions: Cancer of Head and Neck|Pain, Face|Pain, Neck
Interventions: DEVICE: ExAblate Neuro
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sidus Stem-Free Shoulder IDE Study
Status: COMPLETED
Conditions: Osteoarthritis|Posttraumatic Arthrosis|Rheumatoid Arthritis
Interventions: DEVICE: Sidus Stem-Free Total Shoulder Arthroplasty System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate Safety and Tolerability of ALN-TTR01 in Transthyretin (TTR) Amyloidosis
Status: COMPLETED
Conditions: Transthyretin Mediated Amyloidosis (ATTR)
Interventions: DRUG: ALN-TTR01|DRUG: Sterile Normal Saline (0.9% NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Participation on Body Functions Among Youth With Physical Disabilities
Status: ACTIVE_NOT_RECRUITING
Conditions: Cerebral Palsy|Spina Bifida|Musculoskeletal Disorders
Interventions: BEHAVIORAL: Engagement in a 8-week community-based activity program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Antiviral Activity of ANA598 in Patients With Genotype-1 Chronic HCV Infection
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: ANA598 200 mg bid or placebo|DRUG: ANA598 400 mg bid or placebo|DRUG: ANA598 800 mg bid or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ESTxENDS Trial- Substudy on Oxidative Stress Induced by Electronic Nicotine Delivery Systems (ENDS) Measured in EBC
Status: COMPLETED
Conditions: Smoking Cessation|Oxidative Stress
Interventions: OTHER: ENDS (vaporizer/e-cig) and smoking cessation counseling|OTHER: Smoking cessation counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Sequential Systemic Therapy + Intraperitoneal Paclitaxel in Gastric/GEJ Peritoneal Carcinomatosis
Status: RECRUITING
Conditions: Gastric Cancer|Peritoneal Carcinomatosis|Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Paclitaxel|DRUG: Paclitaxel|DRUG: Leucovorin|DRUG: Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Adding Oral Contraceptives to Fluoxetine Improve the Management of Premenstrual Syndrome?
Status: UNKNOWN
Conditions: Premenstrual Syndrome
Interventions: DRUG: Fluoxetine|DRUG: Combined oral contraceptives|DRUG: Placebo 1|DRUG: Placebo 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Ability of UB-612 COVID-19 Vaccine to Boost Immunity of Heterologous COVID-19 Vaccines.
Status: WITHDRAWN
Conditions: COVID-19
Interventions: BIOLOGICAL: UB-612
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Interpersonal Psychotherapy in Adolescents With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Interpersonal Psychotherapy|Polycystic Ovary Syndrome
Interventions: BEHAVIORAL: Interpersonal Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament
Status: RECRUITING
Conditions: Endodontic Disease|Pulp Disease, Dental|Intracanal Medication
Interventions: DRUG: Diclofenac Sodium|DRUG: Calcium hydroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Fingolimod in Taiwanese Adults (≥ 20years) With Relapsing Remitting Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: Fingolimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiac Tumors Interventional （Radio Frequency/Laser Ablation）Therapy
Status: UNKNOWN
Conditions: Cardiac Tumors
Interventions: PROCEDURE: Direct Transthoracic Cardiac Tumor Radio Frequency Ablation Therapy|PROCEDURE: Direct Transthoracic Cardiac Tumor Laser Ablation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Homeostasis in Sarcoidosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Sarcoidosis|Vitamin D Insufficiency
Interventions: DRUG: Ergocalciferol|DRUG: Placebo|DRUG: Calcium Citrate with Vitamin D2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Long-term Safety and Efficacy of AXS-05 in Subjects With Alzheimer's Disease Agitation
Status: ENROLLING_BY_INVITATION
Conditions: Agitation in Patients With Dementia of the Alzheimer's Type|Alzheimer Disease|Agitation, Psychomotor
Interventions: DRUG: AXS-05 (dextromethorphan-bupropion)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stunting Prevention Project in Thatta and Sujawal Districts, Sindh Province, Pakistan
Status: COMPLETED
Conditions: Malnutrition
Interventions: DIETARY_SUPPLEMENT: Wheat Soya Blend (WSB)|DIETARY_SUPPLEMENT: Wawa Mum|DIETARY_SUPPLEMENT: Micronutrient Powders (MNP)|BEHAVIORAL: Behavior change and preventive health massages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Therapeutic Efficacy of Faricimab for Clinical AMD, DME, and RVO Patients
Status: RECRUITING
Conditions: Age-Related Macular Degeneration|Diabetic Macular Edema|Retinal Vein Occlusion
Interventions: DRUG: Faricimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brivanib Alaninate in Treating Patients With Persistent or Recurrent Cervical Cancer
Status: COMPLETED
Conditions: Cervical Adenocarcinoma|Cervical Adenosquamous Carcinoma|Cervical Squamous Cell Carcinoma, Not Otherwise Specified|Persistent Disease|Recurrent Cervical Carcinoma
Interventions: DRUG: Brivanib Alaninate|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Lenalidomide/Rituximab Maintenance for Transplantation Ineligible Patients With PCNSL.
Status: RECRUITING
Conditions: Primary CNS Lymphoma
Interventions: DRUG: Rituximab, lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SOX Versus XELOX for Patients With Peritoneal Metastasis of Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Neoplasm
Interventions: DRUG: SOX|DRUG: XELOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Anabolic Effects of Estrogen on Skeletal Muscles
Status: COMPLETED
Conditions: Estrogen Supplementation
Interventions: OTHER: Exercise + Estrogen|OTHER: Exercise + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Pharmacokinetics, Efficacy and Safety of a Recombinant and Protein-Free Factor VIII (rAHF-PFM) in Hemophilia A Patients - A Continuation of Clinical Study 069901
Status: COMPLETED
Conditions: Hemophilia A
Interventions: DRUG: Antihemophilic factor, recombinant, manufactured protein-free
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of the Glycemic Variability on Macular Retinal Microcirculation and Cognitive Functions in Patient With Type 1 Diabetes
Status: COMPLETED
Conditions: Microvascular Complications|Diabetic Retinopathy|Diabetes|Microangiopathy|Angiography
Interventions: OTHER: Case|OTHER: Control
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of High vs. Low MAP Levels on Clinical Outcomes in Elderly Patients During Noncardiothoracic Surgery
Status: UNKNOWN
Conditions: Aging|Surgery|Blood Pressure|Anesthesia|Blood Loss, Surgical|Postoperative Delirium
Interventions: DRUG: Urapidil|DRUG: Phenylephrine|PROCEDURE: Low-level MAP|PROCEDURE: High-level MAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SS109 and NovoSeven ® PK / PD Profile, and Preliminary Efficacy and Safety of SS109 on Demand Treatment
Status: COMPLETED
Conditions: Male|Hemophilia A With Inhibitor|Hemophilia B With Inhibitor|Hemophilia
Interventions: DRUG: SS109
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Levodopa-Carbidopa Intestinal Gel Open-Label Study in Advanced Parkinson's Disease
Status: COMPLETED
Conditions: Advanced Parkinson's Disease
Interventions: DRUG: Levodopa-carbidopa intestinal gel|DEVICE: CADD-Legacy® 1400 ambulatory infusion pump|DEVICE: PEG tube|DEVICE: J-tube
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Multiple Doses of Nusinersen (ISIS 396443) Delivered to Infants With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Muscular Atrophy
Interventions: DRUG: Nusinersen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Tislelizumab in Combination With Sitravatinib for Recurrent/Metastatic Cervical Cancer After Platinum-Based Chemotherapy
Status: WITHDRAWN
Conditions: Metastatic Cervical Cancer
Interventions: DRUG: Tislelizumab|DRUG: Sitravatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preliminary Efficacy and Safety Study of Oral Nepadutant in Infant Colic
Status: COMPLETED
Conditions: Infantile Colic
Interventions: DRUG: Nepadutant oral solution|DRUG: Nepadutant oral solution|DRUG: Placebo matching Nepadutant oral solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Correction of V-pattern Strabismus by Graded Recession of Inferior Oblique Muscle .
Status: COMPLETED
Conditions: V Pattern Esotropia|Monocular Exotropia With V Pattern
Interventions: PROCEDURE: graded recession of inferior oblique muscle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Empyema
Status: COMPLETED
Conditions: Empyema, Pleural|Pleural Effusion|Pleural Diseases
Interventions: DRUG: Intrapleurally Alteplase vs Intrapleurally Urokinase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy-free Trastuzumab and Pertuzumab in HER2-positive Breast Cancer: FDG-PET Response-adapted Strategy.
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Perjeta|DRUG: Herceptin|DRUG: Docetaxel|DRUG: Carboplatin|DRUG: Letrozole|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Pilot Trial to Address Feasibility and Safety of Oral Zinc in GNAO1 Associated Disorders
Status: RECRUITING
Conditions: GNAO1|Dystonia|Epilepsy|Development Delay|Developmental and Epileptic Encephalopathy 17|Neurodevelopmental Disorder With Involuntary Movements|Choreoathetosis
Interventions: DRUG: Zinc Acetate Dihydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Dexamethasone|DRUG: Cytarabine|DRUG: Methotrexate|DRUG: Rituximab|DRUG: 6-Mercaptopurine|DRUG: Prednisone|DRUG: L-asparaginase
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Curcumin Addition to Standard Treatment on Tumour-induced Inflammation in Endometrial Carcinoma
Status: COMPLETED
Conditions: Endometrial Carcinoma
Interventions: DIETARY_SUPPLEMENT: Curcuphyt
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Avapritinib in Chinese Patients With Gastrointestinal Stromal Tumor (GIST) in the Real World
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastrointestinal Stromal Tumors
Interventions: DRUG: Avapritinib|DRUG: Tyrosine kinase inhibitors other than avapritinib ( imatinib, sunitinib, et al )
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Virtual Reality on Freezing Phenomenon, Balance, Functional Mobility, Participation in Parkinson's Patients
Status: NOT_YET_RECRUITING
Conditions: Parkinson's Disease|Freezing of Gait
Interventions: DEVICE: Task-Oriented Virtual Reality Application with Crowd Simulation|PROCEDURE: Conventional Parkinson Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Use of Dexmedetomidine and Hydrocortisone to Prevent New Onset AF After CABG Surgery
Status: RECRUITING
Conditions: Atrial Fibrillation New Onset
Interventions: DRUG: Dexmedetomidine + Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effects of Two Different Amounts of Mandibular Protrusion in OSA Patients Using Mandibular Advancement Appliance
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Mandibular advancement Appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Amplification of Positivity for Alcohol Use Disorder Co-Occurring With Anxiety or Depression
Status: SUSPENDED
Conditions: Alcoholism|Alcohol Drinking|Drinking Behavior|Alcohol-Related Disorders|Substance-Related Disorders|Mental Disorder|Anxiety|Depression
Interventions: BEHAVIORAL: Amplification of Positivity Training|BEHAVIORAL: Cognitive-behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Jiedu Tongluo Granules for Post-stroke Depression
Status: COMPLETED
Conditions: Post-stroke Depression
Interventions: DRUG: Jiedu Tongluo granules|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Visible Abdominal Distension
Status: NOT_YET_RECRUITING
Conditions: Irritable Bowel Syndrome|Dyspepsia|Functional Bloating
Interventions: BEHAVIORAL: Biofeedback|BEHAVIORAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Alirocumab (REGN727/SAR236553) added-on to Rosuvastatin Versus Other Lipid Modifying Treatments (LMT) (ODYSSEY OPTIONS II)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Alirocumab|DRUG: Rosuvastatin|DRUG: Ezetimibe|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Immunosuppressive Regimens in Kidney Transplant Recipients With Deceased Donors With the Aim of Preventing the Development of Fibrosis / Atrophy of Reducing the Incidence of Cytomegalovirus Infection
Status: UNKNOWN
Conditions: Disorder of Transplanted Kidney|Cytomegalovirus Infections
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD
Status: COMPLETED
Conditions: Atypical Alzheimers Disease|Logopenic Variant of Primary Progressive Aphasia (LPA)|Posterior Cortical Atrophy (PCA)
Interventions: DRUG: C-11 PiB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Grape Seed Extract on Estrogen Levels of Postmenopausal Women
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DIETARY_SUPPLEMENT: Grape Seed Extract|DIETARY_SUPPLEMENT: Grape Seed Extract|DIETARY_SUPPLEMENT: Grape Seed Extract|DIETARY_SUPPLEMENT: Grape Seed Extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Utility of Customised Growth Charts for Identifying Macrosomia and the Effect of Intervention
Status: COMPLETED
Conditions: Obstetric Complication|Ultrasound|Induction of Labor Affected Fetus / Newborn|Fetal Growth Complications
Interventions: PROCEDURE: Induction of labour
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Influence of MCIMT (Modified Constrained Induced Movement Therapy), Bilateral Intensive Treatment, and NDT Approach on the UL Function in Children With Hemiplegic Cerebral Palsy
Status: COMPLETED
Conditions: Hemiplegic Cerebral Palsy
Interventions: BEHAVIORAL: treatment approach - CIMT|BEHAVIORAL: treatment approach - HABIT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Percutaneous Mitral Intervention in Asymptomatic Moderate Mitral Stenosis
Status: COMPLETED
Conditions: Moderate Mitral Stenosis
Interventions: PROCEDURE: Percutaneous Mitral Commissurotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyclosporine in Combination With Carfilzomib and Dexamethasone in Relapsed Multiple Myeloma Refractory to Carfilzomib and High Expression of PPIA Gene in Myeloma Cells
Status: RECRUITING
Conditions: Multiple Myeloma in Relapse|Multiple Myeloma, Refractory
Interventions: DRUG: cyclosporine in combination with carfilzomib and dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Probiotics on Maintenance of Health in Pregnancy and Infants
Status: COMPLETED
Conditions: Pregnancy
Interventions: DIETARY_SUPPLEMENT: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: MiSight 1 Day Post-Approval Study for Effectiveness and Visual Symptoms
Status: RECRUITING
Conditions: Myopia
Interventions: DEVICE: MiSight 1 Day|DEVICE: Proclear 1 day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of rGH Therapy to Prevent Muscle Atrophy in Patients With ACL Tears
Status: COMPLETED
Conditions: Rupture of Anterior Cruciate Ligament
Interventions: DRUG: Somatropin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interaction Study With AZD9291 and Omeprazole in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: PROCEDURE: Pharmacokinetic sampling - AZD9291|DRUG: AZD9291 tablet dosing|DRUG: Omeprazole tablet dosing|PROCEDURE: Pharmacokinetic sampling - AZ5140 and AZ7550
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiparametric Magnetic Resonance Imaging (MRI) in Medullary Sponge Kidney
Status: COMPLETED
Conditions: Medullary Sponge Kidney
Interventions: DIAGNOSTIC_TEST: Multiparametic MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Bortezomib and Pegylated Liposomal Doxorubicin in Patients With Relapsed Multiple Myeloma Previously Treated With Bortezomib
Status: WITHDRAWN
Conditions: Multiple Myeloma
Interventions: DRUG: bortezomib; pegylated liposomal doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison Between Two Strategies for Postpartum Anemia Diagnosis and Follow up After Vaginal Deliveries
Status: COMPLETED
Conditions: Postpartum Anemia
Interventions: OTHER: Monitoring hemoglobin levels following anemia associated symptoms|OTHER: Monitoring hemoglobin levels to detect anemia by screening of women at increased risk for post partum anemia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetics and Pharmacodynamics of Biphasic Insulin Aspart 30 and Biphasic Human Insulin 30 in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart 30|DRUG: biphasic human insulin 30
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of ABI-007 Versus Dacarbazine in Previously Untreated Patients With Metastatic Malignant Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: DRUG: ABI-007|DRUG: Dacarbazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab With Rituximab or Obinutuzumab in Treating Patients With Relapsed or Refractory Follicular Lymphoma or Diffuse Large B Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Diffuse Large B-Cell Lymphoma|Recurrent Follicular Lymphoma|Refractory Diffuse Large B-Cell Lymphoma|Refractory Follicular Lymphoma
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab|BIOLOGICAL: Rituximab|BIOLOGICAL: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel (Albumin-bound) Combined With Oxaliplatin and S-1 Conversion Therapy for Gastric Adenocarcinoma
Status: RECRUITING
Conditions: Gastric Adenocarcinoma
Interventions: DRUG: Paclitaxel (albumin-bound) combined with Oxaliplatin and S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wound Infection Alexis Wound Retractor
Status: COMPLETED
Conditions: Appendicitis
Interventions: DEVICE: Open appendectomy using Alexis Wound Retractor followed by standardized wound closure|PROCEDURE: Open appendectomy with standardized wound closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bladder Conservative Surgery in r Abnormally Invasive Placenta With Bladder Invasion
Status: UNKNOWN
Conditions: Placenta Accreta With Bladder Invasion
Interventions: PROCEDURE: Bladder conservative surgery in placenta accretta
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).
Status: RECRUITING
Conditions: Lung Injury|Preterm Birth
Interventions: PROCEDURE: Positive End-Expiratory Pressure (PEEP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fibrin Sealant for Cholangiotomy Closure Study
Status: UNKNOWN
Conditions: Common Bile Duct Gall Stones|Infection|Bile Leak
Interventions: DRUG: Tisseel, Baxter (Aprotinin and Fibrinogen)|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Self-managed Versus a Predetermined Resistance Training Protocol in Reducing Pain in Individuals With Plantar Fasciopathy
Status: COMPLETED
Conditions: Plantar Fasciopathy
Interventions: OTHER: Self-managed protocol|OTHER: Predetermined protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Tranexamic Acid and Epsilon-aminocaproic Acid in Reducing Bleeding and Transfusions in Cardiac Surgery
Status: COMPLETED
Conditions: Bleeding
Interventions: DRUG: Epsilon-aminocaproic acid administered|DRUG: Tranexamic Acid administered
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Midodrine for the Prevention of Orthostatic Hypotension During Early Mobilization After Fast-track Hip Arthroplasty
Status: COMPLETED
Conditions: Postoperative Orthostatic Hypotension|Postoperative Orthostatic Intolerance
Interventions: DRUG: Midodrine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Ability of Betaine Hydrochloride to Increase Stomach Acid in Healthy Volunteers
Status: COMPLETED
Conditions: Pharmacodynamic
Interventions: DIETARY_SUPPLEMENT: betaine hydrochloride|DRUG: Rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Remote Ischemic Conditioning in Patients With Acute Ischemic Stroke
Status: NOT_YET_RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: PROCEDURE: Remote ischemic conditioning|PROCEDURE: Sham remote ischemic conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Observatonal Study for Effect of Duodenojejunal Bypass and Gastric Bypass on T2DM Patients
Status: COMPLETED
Conditions: Non Insulin Dependent Diabetes Mellitus
Interventions: PROCEDURE: laparoscopic roux en Y gastric bypass / open duodenojejunal bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT