pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Phase 2 Trial Evaluating SNC-102 in Drug-Induced Tardive Dyskinesia
Status: WITHDRAWN
Conditions: Drug-induced Tardive Dyskinesia
Interventions: DRUG: SNC-102|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of the Mindful Caring Education Program on Nurses' Intentionality
Status: COMPLETED
Conditions: Nurses' Perceptions of Intentionality|the Facilitators of Intentionality|the Impediments to Intentionality|Effectiveness of Mindful Caring Education Program
Interventions: OTHER: Mindful Caring Education Program
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Capsaicin Lozenges in Treating Patients With Mucositis Caused by Radiation Therapy
Status: COMPLETED
Conditions: Head and Neck Cancer|Radiation Toxicity
Interventions: DIETARY_SUPPLEMENT: capsaicin|OTHER: placebo|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Multiple Ascending-Dose Study of RG7625 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Placebo|DRUG: RG7625
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Docetaxel, Carboplatin, and Pegfilgrastim in Treating Patients Who Are Undergoing Surgery for Stage II or Stage III Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: pegfilgrastim|DRUG: carboplatin|DRUG: docetaxel|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy, Safety, and Tolerability of Brivaracetam as Monotherapy in Patients 2 to 25 Years of Age With Childhood Absence Epilepsy or Juvenile Absence Epilepsy
Status: RECRUITING
Conditions: Childhood Absence Epilepsy|Juvenile Absence Epilepsy
Interventions: DRUG: Brivaracetam|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Direct Topical Lung T3 Treatment to Improve Outcome & Sequelae of COVID-19 Acute Respiratory Distress Syndrome
Status: NOT_YET_RECRUITING
Conditions: Covid19|SARS-CoV Infection|ARDS|ARDS, Human
Interventions: DRUG: Instilled T3|OTHER: Placebo Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PET Imaging of Solid Tumors by a Novel Tracer, 68Ga-FAPI
Status: RECRUITING
Conditions: Pancreatic Neoplasms|Stomach Neoplasms|Bile Duct Neoplasms|Epithelial Ovarian Cancer
Interventions: DRUG: 68Ga-FAPI-46|DEVICE: PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Novel Delivery Method of Transgender Voice Therapy Using a Mobile Application
Status: NOT_YET_RECRUITING
Conditions: Transitioning Voice of Transgender and Gender Diverse People
Interventions: OTHER: Attuned: A mobile application|OTHER: In-Person Voice Modification Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Hydrotherapy on Neuropathic Pain and Pain Catastrophization in Spinal Cord Injury
Status: UNKNOWN
Conditions: Neuropathic Pain|Spinal Cord Injuries
Interventions: OTHER: Hydrotherapy|OTHER: Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of Three Doses of NS 2330 in Patients With Mild to Moderate Dementia of the Alzheimer's Type
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: NS 2330 (Tesofensine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Preventing Cigarette Use Among Urban Youth Via an M-Health Primary Care Preventive Intervention
Status: COMPLETED
Conditions: Tobacco Use|Drug Use|Adolescent Behavior|Alcohol Use|Sexual Risk Behavior
Interventions: BEHAVIORAL: S4E|BEHAVIORAL: Attention-Matched Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Feasibility of Mobile Game System for Potential Treatment of Developmental Delays
Status: ENROLLING_BY_INVITATION
Conditions: Autism Spectrum Disorder|Autism
Interventions: OTHER: Mobile Game System for Potential Treatment of Developmental Delays
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Double-Blind, Randomized, Parallel, Comparative Study to Evaluate the Efficacy and Safety of an Antidiabetic Agent Repaglinide for the Treatment of Type 2 Diabetes Mellitus Patients
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Repaglinide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Enteral Administration of Docosahexaenoic Acid to Prevent Necrotizing Enterocolitis in Preterm Neonates
Status: COMPLETED
Conditions: Necrotizing Enterocolitis
Interventions: DIETARY_SUPPLEMENT: Docosahexaenoic acid (DHA)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Light Protection of TPN and Oxidative Stress in Preterm Infants
Status: COMPLETED
Conditions: Oxidative Stress in Preterm Infants
Interventions: OTHER: Light-protection of TPN solutions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: PoCUS Guided Fluids to Prevent Post-induction Hypotension
Status: COMPLETED
Conditions: Hypotension on Induction
Interventions: DRUG: Ringer's Lactate|OTHER: IV line
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: RDEA3170 PK/PD Study
Status: COMPLETED
Conditions: Gout
Interventions: DRUG: RDEA3170 4.5 mg|DRUG: RDEA3170 6 mg|DRUG: RDEA3170 12 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sintilimab Combined With Lenvatinib Versus HAIC for Perioperative Treatment of Resectable Primary Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Resectable Hepatocellular Carcinoma
Interventions: DRUG: Sintilimab and Lenvatinib|DRUG: HAIC-FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pressure-limited Ventilation Versus Volume-targeted Ventilation in Preterm Newborns
Status: COMPLETED
Conditions: Neonatal Respiratory Failure
Interventions: DEVICE: Ventilation protocol delivered by the SLE5000 ventilator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Radiation Therapy Before Surgery for the Treatment of Resectable Brain Metastases
Status: WITHDRAWN
Conditions: Malignant Neoplasm, Brain|Brain Tumor
Interventions: OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|RADIATION: Stereotactic Radiosurgery|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics, and Pharmacodynamics of MK-2248 in Participants With Hepatitis C (MK-2248-002)
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: MK-2248
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of How An Ankle Strap Changes Effects of Insole Treatment for Knee Osteoarthritis
Status: COMPLETED
Conditions: Medial Compartment Knee Osteoarthritis
Interventions: DEVICE: Laterally-Wedged Insole with Ankle Strapping|DEVICE: Laterally-Weged Insole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Hemodynamic Effects of Epinephrine Versus Dexmedetomidine as an Adjuvant to Bupivacaine in Caudal Anaesthesia Assessed by Cardiometry
Status: NOT_YET_RECRUITING
Conditions: Anesthesia, Local
Interventions: DRUG: Epinephrine injection|DRUG: Dexmedetomidine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evolution of Coagulation Activity in Non Valvular Atrial Fibrillation Patients Under Apixaban
Status: TERMINATED
Conditions: Coagulation Disorder|Non Valvular Atrial Fibrillation
Interventions: DRUG: Apixaban 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Selinexor in Combination With HAD or CAG Rregimens in Relapsed or Refractory Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Relapsed or Refractory Acute Myeloid Leukemia
Interventions: DRUG: Selinexor|DRUG: Homoharringtonine|DRUG: Daunorubicin|DRUG: Cytarabine|DRUG: Granulocyte Colony-Stimulating Factor|DRUG: Aclacinomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunomodulation Following Transfusion
Status: COMPLETED
Conditions: Blood Component Transfusion
Interventions: BIOLOGICAL: Standard blood components|BIOLOGICAL: Leukoreduced blood components|BIOLOGICAL: Leukoreduced and irradiated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Health Related Quality of Life and Multidimensional Evaluations of Prostate Cancer Subjects Aged ≥ 60 Years Initiating Gonadotropin-Releasing Hormone (GNRH) Agonist Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: OTHER: Data collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Efficacy and Safety of VX-548 for Acute Pain After an Abdominoplasty
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: VX-548|DRUG: HB/APAP|DRUG: Placebo (matched to VX-548)|DRUG: Placebo (matched to HB/APAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COMplete Versus PArtial Open inCisional Hernia Repair (COMPAC-TRIAL)
Status: TERMINATED
Conditions: Incisional Hernia
Interventions: PROCEDURE: complete repair|PROCEDURE: partial repair of the abdominal wall
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of a Single-dose of 12 mg IVERMECTIN as Orally Disintegrating Mini Tablets Versus a Single-dose of 12 mg Regular IVERMECTIN Tablets in Healthy Adults Under Fasting Conditions
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Treatment A (investigational drug) followed by Treatment B (reference drug)|DRUG: Treatment B (reference drug) followed by Treatment A (investigational drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of the Effect of Preoperative Intravenous Amantadine Sulfate on the Postoperative Early Cognitive Functions in a Elderly Patient With Laparoscopic Radical Prostatectomy
Status: UNKNOWN
Conditions: Postoperative Cognitive Dysfunction
Interventions: DRUG: Amantadine Sulfate|DRUG: Placebo (for amantadine sulphate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: CT Air-trapping for the Early Identification of Benralizumab Responders Among Eosinophilic Asthma Patients
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: 48 weeks of Benralizumab|OTHER: Computed tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Pre-, Pro- & Anti-biotics on Gut Microbiota
Status: COMPLETED
Conditions: Human Gut Microbiota
Interventions: DIETARY_SUPPLEMENT: Trametes versicolor extract|DIETARY_SUPPLEMENT: Saccharomyces boulardii|DRUG: Amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Long-term Prognosis of Moderate to Severe Bronchial Hyperresponsiveness (BHR) in Asthmatic Preschool Children
Status: WITHDRAWN
Conditions: Intrinsic Asthma|Allergic Asthma|Allergy|Bronchial Hyperresponsiveness
Interventions: OTHER: methacholine challenge test|OTHER: methacholine challenge test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pragmatic Trial to Determine the Benefit of Behaviorally Enhanced Exercise Incentives and Corticosteroid Injections in Osteoarthritis of the Knee Marching On for Veterans With Osteoarthritis of the Knee
Status: RECRUITING
Conditions: Osteoarthritis of the Knee
Interventions: BEHAVIORAL: Social Incentives and Gamification to Promote Exercise|DRUG: Corticosteroid Injection given in A-B order|BEHAVIORAL: No Social Incentive applied|DRUG: Procedure: Corticosteroid Injection given in B-A order
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Nefopam on Catheter-related Bladder Discomfort
Status: COMPLETED
Conditions: Nefopam|Catheter-related Bladder Discomfort
Interventions: DRUG: Nefopam or saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Feasibility of Combined Focused Ultrasound and Radiotherapy Treatment in Patients With Painful Bone Metastasis
Status: COMPLETED
Conditions: Bone Metastases|Bone Neoplasm|Bone Lesion|Bone Cancer|Pain|Cancer Induced Bone Pain|Radiation Toxicity|Quality of Life|Tumor|Neoplasm Metastasis
Interventions: COMBINATION_PRODUCT: combined radiotherapy and MR-HIFU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison Low-Level Laser Therapy With Cryotherapy in Parturients With Laceration and/or Episiotomy on Pain Reduction
Status: COMPLETED
Conditions: Episiotomy; Complications|Laceration
Interventions: OTHER: Low-Level Laser Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Amyotrophic Lateral Sclerosis (REPAIR-ALS)
Status: WITHDRAWN
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Gold Nanocrystals
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Nab-PTX and Trastuzumab for ER Negative and HER2 Positive Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer|Estrogen Receptor Negative Neoplasm|HER-2 Positive Breast Cancer
Interventions: DRUG: nab-paclitaxel|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrafine Endoscope for Colonoscopy in Diagnosis of Colorectal Diseases
Status: UNKNOWN
Conditions: Colon Disease;|Rectal Disease
Interventions: DEVICE: Ultrafine Endoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of NGX-4010 for the Treatment of Postherpetic Neuralgia
Status: COMPLETED
Conditions: Peripheral Nervous System Diseases|Pain|Neuralgia|Herpes Zoster|Shingles
Interventions: DRUG: NGX-4010
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Educational Intervention as Supporting Element in the Treatment of Functional Constipation in Children
Status: NOT_YET_RECRUITING
Conditions: Constipation - Functional
Interventions: BEHAVIORAL: Educational information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Lefamulin to Moxifloxacin (With or Without Linezolid) for the Treatment of Adults With Pneumonia
Status: COMPLETED
Conditions: Community Acquired Pneumonia
Interventions: DRUG: lefamulin|DRUG: Moxifloxacin|DRUG: Linezolid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Reducing Effect of Transcutaneous Electrical Nerve Stimulation in Patients With Chronic Low Back Pain or Lumbo-radiculalgia
Status: COMPLETED
Conditions: Chronic Low Back Pain|Chronic Lumbo-radiculalgia
Interventions: DEVICE: CEFAR PRIMO TENS Class IIA (active)|DEVICE: CEFAR PRIMO TENS Class IIA (no active)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intermittent Fasting in Nonalcoholic Fatty Liver Disease
Status: UNKNOWN
Conditions: Intermittent Fasting|Non-Alcoholic Fatty Liver Disease|Insulin Resistance|Obesity|Gut Microbiota
Interventions: BEHAVIORAL: Calorie restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Relation Between Dedicated Extremity MRI Synovitis and Structural Deterioration Radiographic in Patients With Rheumatoid Arthritis in Clinical Remission. Preliminary Study
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: OTHER: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study to Evaluate the Effect of Rifampin on the Drug Levels in Blood and Safety of BMS-986235 in Healthy Participants
Status: WITHDRAWN
Conditions: Healthy Participants
Interventions: DRUG: BMS-986235 (Treatment A)|DRUG: Rifampin (Treatment B)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of DYSPORT® Using 2mL Dilution in Adults With Cervical Dystonia.
Status: COMPLETED
Conditions: Cervical Dystonia
Interventions: BIOLOGICAL: Botulinum toxin type A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of MSC-EVs in Acute/Acute-on-Chronic Liver Failure
Status: WITHDRAWN
Conditions: Acute-On-Chronic Liver Failure|Acute Liver Failure
Interventions: BIOLOGICAL: MSC-EVs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Cardio Mato (Grade A Lyc-O-Mato, a Tomato Extracted Lycopene) on Blood Pressure
Status: COMPLETED
Conditions: Prehypertension
Interventions: DIETARY_SUPPLEMENT: Cardio Mato|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of the Presence of Active Trigger Points in the Muscles Innervated by the Affected Nerve Roots on the Treatment Results of Transforaminal Epidural Steroid Injection in Patients With Lumbar Radiculopathy.
Status: UNKNOWN
Conditions: Trigger Point Pain, Myofascial|Lumbar Radiculopathy
Interventions: PROCEDURE: Transforaminal epidural steroid injection(TFESI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Atypical Chronic Myeloid Leukemia|Chronic Myelomonocytic Leukemia|Essential Thrombocythemia|Myelodysplastic/Myeloproliferative Neoplasm|Myelofibrosis|Polycythemia Vera|Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: DRUG: Carboplatin|DRUG: Topotecan|DRUG: Topotecan Hydrochloride|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Caloric Restriction and Protein Intake on Metabolism and Anabolic Sensitivity
Status: COMPLETED
Conditions: Weight Loss|Starvation
Interventions: OTHER: Caloric Restriction|OTHER: Protein|OTHER: Exercise|DIETARY_SUPPLEMENT: Calcium and Vitamin D|OTHER: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Safety and PK Study of Injectable Risperidone-SABER and the DosePro Delivery System in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: risperidone-SABER|OTHER: ZX003:risperidone-SABER and the DosePro System|DRUG: risperidone-SABER|DRUG: Risperidone-SABER
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Helium/Oxygen Compared to Air/Oxygen in Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Helium/Oxygen 78%/22%|DRUG: Air/Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SCH 727965 in Patients With Advanced Breast and Lung Cancers (Study P04716)
Status: COMPLETED
Conditions: Breast Neoplasms|Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: SCH 727965|DRUG: Capecitabine|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Examining Rapid Acting Intra-Muscular Olanzapine in Japanese Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Olanzapine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Safety and Protective Efficacy of Vaccine Candidate PfSPZ-CVac and MVA ME-TRAP/ ChAd63 ME-TRAP in Adults
Status: NOT_YET_RECRUITING
Conditions: Malaria
Interventions: DRUG: Pyronaridine Tetraphosphate, Artesunate Drug Combination|BIOLOGICAL: PfSPZ Challenge (NF54)|BIOLOGICAL: MVA ME-TRAP|BIOLOGICAL: ChAd63 ME-TRAP|BIOLOGICAL: Sodium chloride (NaCl) 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Comparing the Effectiveness and Safety of Extended Release Tramadol Versus Placebo for the Treatment of Osteoarthritis (OA) of the Knee
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DRUG: Tramadol HCl ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study of Avutometinib (VS-6766) + Sotorasib With or Without Defactinib in KRAS G12C NSCLC Patients
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer|KRAS Activating Mutation
Interventions: DRUG: avutometinib and sotorasib|DRUG: avutometinib and sotorasib and defactinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-dose Buccal Buprenorphine: Relative Abuse Potential and Analgesia
Status: RECRUITING
Conditions: Analgesia|Abuse Opioids|Pain
Interventions: DRUG: Buccal Buprenorphine 300 mcg|DRUG: Buccal Buprenorphine 600 mcg|DRUG: Buccal Buprenorphine 900 mcg|DRUG: Buccal Placebo|DRUG: Oral Placebo|DRUG: Oral immediate-release oxycodone 10mg|DRUG: Buccal Buprenorphine 450mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Machine Learning Modeling of Intraoperative Hemodynamic Predictors of Postoperative Outcomes
Status: COMPLETED
Conditions: Perioperative/Postoperative Complications|Morbidity, Multiple|Surgery|Anesthesia|Death
Interventions: OTHER: Blood pressure|OTHER: Heart rate|OTHER: Use of hemodynamic medications (i.e. special medications for blood pressure)|OTHER: Oxygen saturation by pulse oximetry (SpO2)|OTHER: End-tidal Carbon dioxide (EtCO2)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Flutiform K-haler in Patients With Uncontrolled Asthma Following Mid-dose ICS/LABA DPI Therapy
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: Brand Name: Flutiform K-haler
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobilization of Stem Cells With AMD3100 (Plerixafor) in Non-Hodgkin's Lymphoma Patients
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin
Interventions: DRUG: Granulocyte colony-stimulating factor plus plerixafor|DRUG: Granulocyte colony-stimulating factor plus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Caphosol in Oral Mucositis Due to Targeted Therapy
Status: COMPLETED
Conditions: Oral Complaints|Renal Cell Carcinoma|Hepatocellular Carcinoma|Gastrointestinal Stromal Tumors
Interventions: OTHER: supersaturated calcium-phosphate|OTHER: sodium chloride 0.9 %
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: the Pharmacy Intervention Team Hospital-based (PITH) for People Study: Effect on Clinical and Economic Outcomes
Status: UNKNOWN
Conditions: Adverse Drug Reaction|Medication Administered in Error
Interventions: OTHER: integrated medicines management
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Streamlined Geriatric and Oncological Evaluation Based On IC Technology
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Comorbidities and Coexisting Conditions|Lung Cancer|Colorectal Cancer|Prostate Cancer
Interventions: OTHER: GERONTE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Validation of Functional Imaging as Predictive Tool for Outcome of Mandibular Replacement Appliance Therapy in Obstructive Sleep Apnea Hypopnea Syndrome Patients
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea Syndrome
Interventions: RADIATION: CT scan|DEVICE: Alice PDx polygraphy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Implantation of Allogenic Mesenchymal Stem Cell From Umbilical Cord Blood for Osteoarthritis Management
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Hyaluronic Acid|BIOLOGICAL: Umbilical Cord Mesenchymal Stem Cell|BIOLOGICAL: Recombinant Human Somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DS-8201a Versus T-DM1 for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive, Unresectable and/or Metastatic Breast Cancer Previously Treated With Trastuzumab and Taxane [DESTINY-Breast03]
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab deruxtecan (T-DXd)|DRUG: Ado-trastuzumab emtansine (T-DM1)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Glyceryl Trinitrate Patches in Arteriovenous Fistulas
Status: COMPLETED
Conditions: Renal Failure
Interventions: DRUG: GTN patch|DRUG: placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Seroquel SR in Combination With an Antidepressant in Treatment of Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Quetiapine|DRUG: Amitriptyline|DRUG: Bupropion|DRUG: Citalopram|DRUG: Duloxetine|DRUG: Escitalopram|DRUG: Fluoxetine|DRUG: Paroxetine|DRUG: Sertraline|DRUG: Venlafaxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Long Term Ventilation Support on the Quality of Life of ALS Patients and Their Families
Status: RECRUITING
Conditions: Amyotrophic Lateral Sclerosis|Motor Neuron Disease|Nervous System Diseases|Spinal Cord Diseases|Neurodegenerative Diseases|TDP-43 Proteinopathies
Interventions: DEVICE: Long term mechanical ventilation support|DEVICE: No long term mechanical ventilation support
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Multiple-Dose Administration of JNJ-42847922 on Midazolam and Warfarin in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-42847922|DRUG: Midazolam|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anesthesia Technique and Lower Limb Revascularization Patency
Status: COMPLETED
Conditions: Regional Anesthesia, Vascular Grafting, Vascular Patency
Interventions: PROCEDURE: NSQIP Lower Extremity Open (LEO) procedure-targeted dataset (i.e. undergoing Lower extremity open revascularization) from 2014-2019
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Window of Opportunity Study of IPI-549 in Patients With Locally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma|Head and Neck Cancer|Head and Neck Carcinoma|Head and Neck Cancer Stage IV|Head and Neck Cancer Stage III|HPV-Related Carcinoma|HPV-Related Malignancy|HPV-Related Squamous Cell Carcinoma
Interventions: DRUG: IPI-549
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Mabthera Alone and in Combination With Either Cyclophosphamide or Methotrexate in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Cyclophosphamide|DRUG: Methotrexate|OTHER: Placebo Cyclophosphamide|OTHER: Placebo Methotrexate|OTHER: Placebo Rituximab|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anthocyanin & Phenolic Acids Bioavailability & Antioxidant Capacity After Consumption of Purple Wheat Products in Adults
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Purple Wheat Crackers|OTHER: Purple Wheat Granola Bars
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Determine the Performance of the Press Fit Condylar (P.F.C.) Sigma RP-F Knee System
Status: TERMINATED
Conditions: Osteoarthritis
Interventions: DEVICE: P.F.C. Sigma RP-F Total Knee Replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Generic VEL/SOF With or Without RBV for HIV/HCV Coinfected Patients
Status: COMPLETED
Conditions: Hepatitis C Virus Infection, Response to Therapy of|Human Immunodeficiency Virus
Interventions: DRUG: Sofosbuvir and Velpatasvir|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: C-Met Inhibitor AMG 337, Oxaliplatin, Leucovorin Calcium, and Fluorouracil in Treating Patients With Advanced Stomach or Esophageal Cancer
Status: WITHDRAWN
Conditions: Adenocarcinoma of the Esophagus|Adenocarcinoma of the Gastroesophageal Junction|Diffuse Adenocarcinoma of the Stomach|Gastrointestinal Cancer|Intestinal Adenocarcinoma of the Stomach|Mixed Adenocarcinoma of the Stomach|Stage IIIA Esophageal Cancer|Stage IIIA Gastric Cancer|Stage IIIB Esophageal Cancer|Stage IIIB Gastric Cancer|Stage IIIC Esophageal Cancer|Stage IIIC Gastric Cancer|Stage IV Esophageal Cancer|Stage IV Gastric Cancer
Interventions: DRUG: c-Met inhibitor AMG 337|OTHER: placebo|DRUG: oxaliplatin|DRUG: leucovorin calcium|DRUG: fluorouracil|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Vitamin C Supplementation Intervention
Status: COMPLETED
Conditions: Heart Failure
Interventions: DIETARY_SUPPLEMENT: Vitamin C 500 mg|DIETARY_SUPPLEMENT: Vitamin C 1000 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Inducing a Hypothyroxinemic State in Patients With Recurrent Glioblastoma or Gliosarcoma
Status: WITHDRAWN
Conditions: Recurrent Glioblastoma|Recurrent Gliosarcoma
Interventions: DRUG: Liothyronine|DRUG: Lomustine|DRUG: Methimazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of DWP14012 in Prevention of NSAIDs Induced Peptic Ulcer
Status: COMPLETED
Conditions: Peptic Ulcer
Interventions: DRUG: DWP14012 20mg|DRUG: Lansoprazole 15 mg|DRUG: DWP14012 20mg placebo|DRUG: Lansoprazole 15 mg placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of a Management Strategy of Functional Bowel Disordes Related to Irritable Bowel Syndrome (IBS) With a Mixture of 8 Microbiotic Strains
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Lactichoc|OTHER: Stool sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Rilzabrutinib in Adult Patients With Immune Thrombocytopenia (ITP)
Status: ACTIVE_NOT_RECRUITING
Conditions: Immune Thrombocytopenia|Immune Thrombocytopenic Purpura
Interventions: DRUG: Rilzabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rheolytic Thrombectomy For Acute Deep Vein Thrombosis Of Whole Lower Limb
Status: RECRUITING
Conditions: Deep Vein Thrombosis
Interventions: DEVICE: pharmacomechanical thrombectomy (PMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Facilitated Implementation of Antibiotic Stewardship in Wisconsin Nursing Homes
Status: COMPLETED
Conditions: UTI - Urinary Tract Infection
Interventions: BEHAVIORAL: Externally-facilitated implementation|BEHAVIORAL: Internally-driven implementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Placebo|DRUG: 250 mg CK-2017357|DRUG: 500 mg CK-2017357
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Point Of Care With Serial NT-proBNP Measurement in Patients With Acute Decompensation of Heart Failure
Status: COMPLETED
Conditions: Acute Decompensated Heart Failure
Interventions: OTHER: Serial measurements of NT-pro BNP, potassium, sodium, and creatinine every second business day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Early Versus Standard Start of Anti-HIV Therapy for Treatment-Naive Adults in Haiti
Status: COMPLETED
Conditions: HIV Infections|Tuberculosis
Interventions: DRUG: Efavirenz|DRUG: Lamivudine/Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Treatment of Anemia in Pregnancy
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: iron sucrose (200 mg VENOFER®)|DRUG: recombinant human erythropoietin (10,000 U EPREX®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Small Nudge for Better Health Through Reduced Salt Intake, Increased Vegetable Intake, and Smaller Portion Size
Status: COMPLETED
Conditions: Cardiovascular Disease|Obesity
Interventions: BEHAVIORAL: Nudged to eat less added salt and more other seasonings|BEHAVIORAL: Nudged to avoid foods high in salt content, and to choose foods low in salt content|BEHAVIORAL: Nudged to eat more vegetables|BEHAVIORAL: Nudged to eat smaller portions|BEHAVIORAL: Nudged to eat less calorie-dense food
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PRAsugrel or clopIdogrel In Acute Coronary SyndromE With CYP2C19 GENEtic Variants
Status: COMPLETED
Conditions: Acute Coronary Syndromes
Interventions: DRUG: Prasugrel|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Neuromodulation of Lidocaine and Capsaicin Cream Effects on Pain Experience
Status: COMPLETED
Conditions: Pain
Interventions: DEVICE: transcranial direct current stimulation (tDCS)|OTHER: Lidocaine cream|OTHER: Capsaicin cream|OTHER: Control cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Probiotics on Blood Pressure Management
Status: SUSPENDED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: Lactobacillus paracasei dietary supplement|DIETARY_SUPPLEMENT: Placebo controls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Physiologic Effects of Intranasal Oxytocin on Sarcopenic Obesity
Status: COMPLETED
Conditions: Obesity|Sarcopenic Obesity|Sarcopenia|Aging|Sedentary Lifestyle
Interventions: DRUG: Oxytocin nasal spray|DRUG: Placebo nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: TENS Trial to Prevent Neuropathic Pain in SCI
Status: TERMINATED
Conditions: Spinal Cord Injuries
Interventions: DEVICE: TENS|OTHER: Sham TENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety of Seletracetam in Adult Patients With Refractory Partial Onset Seizures
Status: WITHDRAWN
Conditions: Epilepsies, Partial
Interventions: DRUG: Seletracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Tezepelumab Phase 1 PK Study in Healthy Chinese Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: BIOLOGICAL: Experimental: Tezepelumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: UF-BMT-HSCT-001: A Non-Interventional Study Evaluating Diet in HSCT Survivors
Status: COMPLETED
Conditions: Hematopoietic Neoplasm
Interventions: OTHER: Dietary intake -Food Frequency Questionnaire|OTHER: Receptivity to Participating in Diet Interventions
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of Changes of Periocular Skin Sensation Following Eyelid and Ocular Surface Surgeries
Status: UNKNOWN
Conditions: Blepharoptosis|Blepharochalasis, Superior|Ectropion|Entropion
Interventions: DEVICE: Cochet-Bonnet aesthesiometer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: First Time in Human (FTIH) Safety and Pharmacokinetics (PK) Study of GSK3036656 in Healthy Subjects
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: GSK3036656|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Keloids With Fractional Erbium Laser-Assisted 5-Fluorouracil Versus Laser-Assisted Corticosteroid
Status: COMPLETED
Conditions: Keloid Scar
Interventions: COMBINATION_PRODUCT: Fractional erbium:YAG-assisted drug delivery of 5-fluorouracil|COMBINATION_PRODUCT: Fractional erbium:YAG-assisted drug delivery of triamcinolone acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of APG-157 in Head and Neck Cancer
Status: RECRUITING
Conditions: Head and Neck Cancer|Squamous Cell Carcinoma of Oral Cavity|Squamous Cell Carcinoma of the Oropharynx
Interventions: DRUG: APG-157
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Diabetes Mellitus on Cholesterol Metabolism
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus|Hypercholesterolemia
Interventions: DRUG: simvastatin or ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Next-day Residual Effects of TS-142 in Healthy Elderly Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: TS-142|DRUG: TS-142|DRUG: Zopiclone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Apoptotic Cell (AC) Uptake by Human Alveolar Macrophages (AM)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: PROCEDURE: Fiberoptic bronchoscopy|PROCEDURE: blood draw|PROCEDURE: intravenous catheter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: LLIN Evaluation in Uganda Project
Status: COMPLETED
Conditions: Malaria
Interventions: OTHER: long lasting insecticidal nets with alpha-cypermethrin + pyriproxyfen (PPF LLIN, Royal Guard))|OTHER: long lasting insecticidal nets with deltamethrin + piperonyl butoxide (PBO LLIN, PermaNet 3.0))|BEHAVIORAL: Social behaviour change communication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of HMBD-002, a Monoclonal Antibody Targeting VISTA, as Monotherapy and Combined With Pembrolizumab
Status: RECRUITING
Conditions: Cancer|Tumor, Solid|Nonsmall Cell Lung Cancer|Triple Negative Breast Cancer|Malignant Neoplasm|Metastatic Cancer|Advanced Solid Tumor
Interventions: DRUG: HMBD-002|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medial and Lateral Combined Ligament Arthroscopic Repair for Multidirectional Ankle Instability: Case Series
Status: COMPLETED
Conditions: Ankle Injuries|Ligament Injury|Joint Instability|Deltoid Ligament; Sprain (Strain) (Ankle)|Talofibular Ligament Tear
Interventions: PROCEDURE: Arthroscopic Brostrom combined with Arthroscopic Deltoid Repair
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of PRP on Wound Healing in High Risk Patients Undergoing Abdominal Hysterectomy
Status: NOT_YET_RECRUITING
Conditions: Wound Heal|Abdominal Wound|PRP
Interventions: BIOLOGICAL: Platelets Rich plasma of the same patient
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION