pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: PBF-1681 (Ferric Citrate) for the Treatment of IDA in Patients With NDD-CKD
Status: COMPLETED
Conditions: Anemia of Chronic Kidney Disease
Interventions: DRUG: Ferric citrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hydrogen/Oxygen Mixed Gas Inhalation for Coronavirus Disease 2019 (COVID-19)
Status: COMPLETED
Conditions: Covid-19|Hydrogen/Oxygen Mixed Gas|Dyspnea
Interventions: DEVICE: Hydrogen Oxygen Generator with Nebulizer|OTHER: Standard-of-care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Fecal Microbiota Transplantation on Cognitive Function in T1DM
Status: RECRUITING
Conditions: Type 1 Diabetes
Interventions: DRUG: fecal microbiota transplantation|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Asian American Partnerships in Research and Empowerment (AsPIRE)
Status: COMPLETED
Conditions: Hypertensive Heart Disease|Hypertension
Interventions: BEHAVIORAL: More intensive CHW Intervention|BEHAVIORAL: Less Intensive CHW Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Encorafenib Plus Binimetinib for People With BRAF V600 Mutated Relapsed/Refractory HCL
Status: RECRUITING
Conditions: Hairy Cell Leukemia
Interventions: DRUG: binimetinib|DRUG: Encorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sulodexide in Overt Diabetic Nephropathy
Status: TERMINATED
Conditions: Diabetic Nephropathy
Interventions: DRUG: Sulodexide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Application of PEGylated Recombinant Human Granulocyte Stimulating Factor Injection (PEG-rhG-CSF) in Chemotherapy of Elderly Lymphoma Patients
Status: UNKNOWN
Conditions: Elderly Lymphoma Patients
Interventions: DRUG: PEG-rhG-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Degarelix Acetate Before and During Radiation Therapy in Treating Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Adenocarcinoma|Stage IIA Prostate Cancer|Stage IIB Prostate Cancer|Stage III Prostate Cancer|Stage IV Prostate Cancer
Interventions: DRUG: Degarelix|RADIATION: External Beam Radiation Therapy|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pediatric Transcranial Static Magnetic Field Stimulation to Improve Motor Learning
Status: COMPLETED
Conditions: Healthy|Pediatrics
Interventions: DEVICE: Transcranial Static Magnetic Field Stimulation (tSMS)|DEVICE: Sham Transcranial Static Magnetic Field Stimulation (tSMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Dual-wave Boluses in Children With Type 1 Diabetes Insulin Boluses in Children With Type 1 Diabetes
Status: UNKNOWN
Conditions: Type 1 Diabetes
Interventions: DEVICE: Dual-bolus|DEVICE: Standard bolus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Pharmacodynamics of Cilofexor in Adults With Normal and Impaired Hepatic Function
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis (NASH)|Primary Sclerosing Cholangitis (PSC)
Interventions: DRUG: Cilofexor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ipragliflozin Compared With Sitagliptin in Uncontrolled Type 2 Diabetes With Sulfonylurea and Metformin
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Ipragliflozin|DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence Of Low Dose Intrathecal Naloxone On Bupivacaine - Fentanyl Spinal Anaesthesia For Lower Limb Orthopedic Surgery In Elderly Patients
Status: COMPLETED
Conditions: Anesthesia, Spinal|Elderly
Interventions: DRUG: Bupivacaine-fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Bevacizumab Versus Placebo in Combination With Carboplatin/Paclitaxel in Participants With Advanced or Recurrent Non-Squamous Non-Small Cell Lung Cancer Who Have Not Received Previous Chemotherapy
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Bevacizumab|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Irreversible Electroporation(IRE) For Unresectable Head and Neck Neoplasms
Status: COMPLETED
Conditions: Head and Neck Neoplasms
Interventions: PROCEDURE: Irreversible electroporation (IRE)|DEVICE: NanoKnife
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Granulocyte-colony Stimulating Factors or Antibiotics for Primary Prophylaxis for Febrile Neutropenia
Status: COMPLETED
Conditions: Early Stage Breast Cancer
Interventions: DRUG: Ciprofloxacin|DRUG: Neupogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Food Allergy - Tubes - Adenoids (FATA) Trial
Status: WITHDRAWN
Conditions: Otitis Media With Effusion|Food Hypersensitivity
Interventions: OTHER: Food Allergy Testing|PROCEDURE: Adenoidectomy|PROCEDURE: BMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjusting Antiretroviral Therapy Dosage Using Therapeutic Drug Monitoring
Status: UNKNOWN
Conditions: Human Immunodeficiency Virus|HIV Infections
Interventions: DRUG: Reducing dose of Lopinavir|DRUG: Reducing dose of efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Nitrate on Brown Fat
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DIETARY_SUPPLEMENT: Concentrated beetroot juice|DIETARY_SUPPLEMENT: Nitrate depleted beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Block Pressor Response to Intubation
Status: NOT_YET_RECRUITING
Conditions: Intubation Complication
Interventions: DRUG: Dexmedetomidine|DRUG: Magnesium sulphate|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Adjuvant Hypofractionated Stereotactic Radiosurgery for Intermediate-risk Meningioma
Status: NOT_YET_RECRUITING
Conditions: Meningioma|Meningioma, Malignant|Recurrent Meningioma
Interventions: RADIATION: Hypofractionated Stereotactic Radiosurgery (SRS)|PROCEDURE: Magnetic Resonance Imaging (MRI)|PROCEDURE: Computed Tomography (CT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Therapy of Pegylated Interferon Alfa-2a and Tenofovir Versus Tenofovir Monotherapy in Chronic Hepatitis B
Status: COMPLETED
Conditions: Hepatitis B
Interventions: DRUG: Tenofovir|DRUG: Peginterferon-alfa 2a and tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Weekly Genexol-PM in Patients With Hepatocelluar Carcinoma After Failure of Sorafenib
Status: TERMINATED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Genexol-PM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Refinement and Assessment of New Magnetic Resonance Imaging (MRI) Technologies for Vascular, Abdominal, and Pelvic Exams
Status: COMPLETED
Conditions: Healthy
Interventions: PROCEDURE: MRI Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Compare Ticagrelor vs Clopidogrel on the Reduction of Arterial Stiffness and Wave Reflectionsin Patients With CAD.
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Feasibility Study of Transcutaneous Upper Airway Stimulation in Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|OSA
Interventions: DEVICE: Transcutaneous Upper Airway Stimulation Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Snack Foods and Their Impact on Gastrointestinal Microbiology, Function and Symptoms
Status: COMPLETED
Conditions: Human Microbiome|Eating Behavior
Interventions: DIETARY_SUPPLEMENT: Intervention snack 1|DIETARY_SUPPLEMENT: Intervention snack 2|DIETARY_SUPPLEMENT: Control snack
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Higher Percentage of CD34+ CD38- Cells Detected by Multiparameter Flow Cytometry From Leukapheresis Products Predicts Unsustained Complete Remission in Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: OTHER: PBSC mobilization and leukapheresis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ultrasound-Guided Continuous Sciatic Nerve Blocks: Popliteal Versus Subgluteal Catheters
Status: TERMINATED
Conditions: Foot Surgery
Interventions: PROCEDURE: Subgluteal Sciatic Nerve Block|PROCEDURE: Popliteal Sciatic Nerve Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of the Immunogenicity, Reactogenicity and Tolerability of Two Schedules of a 4CmenB Vaccine in Adolescents and Young Adults
Status: COMPLETED
Conditions: Meningococcal Serogroup B
Interventions: BIOLOGICAL: Bexsero®|BIOLOGICAL: Havrix®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Low-dose Interferon-alfa2a on Peri-operative Immune Suppression
Status: RECRUITING
Conditions: Colon Cancer
Interventions: DRUG: Pegasys|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Meta-Iodobenzylguanidine (123I mIBG) Scintigraphy in Patients Being Evaluated for Phaeochromocytoma or Neuroblastoma
Status: COMPLETED
Conditions: Pheochromocytoma|Neuroblastoma
Interventions: DRUG: 123I-mIBG (meta-iodobenzylguanidine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Avelumab and M6620 for the Treatment of DDR Deficient Metastatic or Unresectable Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Malignant Solid Neoplasm|Refractory Malignant Solid Neoplasm|Unresectable Malignant Solid Neoplasm
Interventions: DRUG: Avelumab|DRUG: Berzosertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Multimodal Analgesia in Decreasing Perioperative Pain in Tibial Plateau Fractures
Status: ACTIVE_NOT_RECRUITING
Conditions: Tibial Plateau Fractures
Interventions: DRUG: Saline injection|DRUG: Multimodal injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Etanercept Therapy for Nails Psoriasis Monitoring With Noninvasive Imaging
Status: UNKNOWN
Conditions: Psoriasis|Psoriatic Arthritis|Psoriatic Nail
Interventions: DRUG: Etanercept|DEVICE: OCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial for the Treatment of Cardiac AL-Amyloidosis With the Green Tea Compound Epigallocatechin-3-gallate (TAME-AL)
Status: COMPLETED
Conditions: Light Chain (AL) Amyloidosis|Cardiac Involvement
Interventions: DRUG: Epigallocatechin-3-gallate (EGCG)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Fondazione Genomic SARS-CoV-2 Study (COVID-19)
Status: COMPLETED
Conditions: COVID-19|Genetic Predisposition
Interventions: GENETIC: identify genetic determinants of the predisposition to develop respiratory failure|GENETIC: identify genetic determinants of the predisposition to develop respiratory failure|GENETIC: identify genetic determinants of the predisposition to develop respiratory failure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Non-invasive Ventilation With Neurally Adjusted Ventilatory Assist Versus Nasal Continuous Airway Pressure in Premature Infants
Status: COMPLETED
Conditions: Respiratory Distress Syndrome (RDS) of Neonate
Interventions: DEVICE: NIV NAVA|DEVICE: Nasal continuous positive airway pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of Photodynamic Therapy in the Treatment of Lesions of the Lichen Planus Type in the Oral Mucosa and Its Diagnostics With the Use of Autofluorescence, in Various Wavelength Ranges, in Combination With the Use of Texture Analysis and Fractal Dimension
Status: COMPLETED
Conditions: Oral Lichen Planus
Interventions: DEVICE: PDT Therapy|DRUG: Triamcinolone (Substance) therapy side
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of an Individualized Patient Support Program on Treatment Satisfaction in Fingolimod-treated Patients With RRMS
Status: WITHDRAWN
Conditions: Relapsing-remitting Multiple Sclerosis
Interventions: OTHER: individualized patient support program|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Radiation Therapy Before Surgery Followed by Gemcitabine in Treating Patients With Pancreatic Cancer
Status: COMPLETED
Conditions: Acinar Cell Adenocarcinoma of the Pancreas|Duct Cell Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage II Pancreatic Cancer|Stage III Pancreatic Cancer
Interventions: DRUG: oxaliplatin|DRUG: irinotecan|DRUG: leucovorin|DRUG: 5-fluorouracil|DRUG: capecitabine|RADIATION: radiation|PROCEDURE: surgery|DRUG: gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurocognitive Risks in Children With Solid Tumors
Status: UNKNOWN
Conditions: Solid Tumor in Children
Interventions: OTHER: The WISC-IV|OTHER: The CMS (CHILD MEMORY SCALE)|OTHER: CONNERS|OTHER: BRIEF|OTHER: PEDS-QL|OTHER: State Trait Anxiety Inventory|OTHER: Child Depression Inventory
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Pharmacokinetic Characteristics of HD203 Liquid in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Etanercept (Enbrel)|BIOLOGICAL: HD203
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using INDOcyanine Green to Analyse Ovarian Vascularization After Ovarian Laparoscopic CYStectomy
Status: COMPLETED
Conditions: Ovarian Cysts|Endometriosis|Fertility
Interventions: DIAGNOSTIC_TEST: Use of Indocyanine Green in laparoscopic ovarian cystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Randomized Trial Comparing Standard of Care Versus Immune- Based Combination in Relapsed Stage III Non-small-cell Lung Cancer (NSCLC) Pretreated With Chemoradiotherapy and Durvalumab
Status: RECRUITING
Conditions: Non-small-cell Lung Cancer Patients
Interventions: DRUG: Durvalumab|DRUG: Olaparib tablet|DRUG: Single-agent chemotherapy|DRUG: Platinum doublet chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Computer-Based Behavior Change Guide in Increasing Physical Activity in Patients With Prostate Cancer Who Have Received Androgen Deprivation Therapy
Status: COMPLETED
Conditions: Prostate Carcinoma
Interventions: OTHER: Computer-Assisted Intervention|OTHER: Computer-Assisted Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Trial of All-trans-retinoic Acid, Bevacizumab and Atezolizumab in Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: all trans Retinoic Acid|DRUG: Atezolizumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lens Extraction Combined With Goniosynechialysis Versus Trabeculectomy
Status: RECRUITING
Conditions: Glaucoma, Angle-Closure
Interventions: PROCEDURE: Lens extraction combined with goniosynechialysis|PROCEDURE: Trabeculectomy surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing a Diagnostic and Treatment Strategy of Upfront CTCA With SOC in Patients With Chest Pain and Suspected CAD
Status: RECRUITING
Conditions: Chest Pain|CAD
Interventions: RADIATION: CT Coronary Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety Study to Evaluate FluMist in Immunocompromised Children
Status: COMPLETED
Conditions: Cancer
Interventions: BIOLOGICAL: FluMist|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Safety, Pharmacokinetic and Pharmacodynamic Study of PUR0200 in COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: PUR0200|DRUG: PUR0200 Placebo|DRUG: Active comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics and Safety of Etavopivat in Pediatric Patients With Sickle Cell Disease
Status: RECRUITING
Conditions: Sickle Cell Disease
Interventions: DRUG: Etavopivat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cisplatin Combined With Radiation Therapy and Hyperthermia in Treating Patients With Stage II, Stage III, or Stage IV Cervical Cancer
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: DRUG: cisplatin|PROCEDURE: hyperthermia treatment|RADIATION: brachytherapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Atacicept in Subjects With Active Lupus Nephritis (COMPASS)
Status: SUSPENDED
Conditions: Lupus Nephritis (LN)
Interventions: DRUG: Atacicept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Observation of ImageReady™ MR Conditional Pacing System in China
Status: COMPLETED
Conditions: Arhythmia|Atrioventricular Heart-block|Chronic Bundle Branch or Branch Block|Carotid Sinus Hypersensitivity Reaction Syndrome|Vasovagal Syncope
Interventions: DEVICE: ImageReady™ MR Conditional Pacing System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use Of Esomeprazole In Postoperative Bariatric Surgery Patients Users And Non-Users Of Nonsteroidal Anti-Inflammatory Drugs (NSAIDS)
Status: COMPLETED
Conditions: Postoperative Bariatric Surgery
Interventions: DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of the Effect of Diet in Overweight or Obese Patients With Psoriasis on Light Therapy
Status: COMPLETED
Conditions: Psoriasis|Weight Loss|Diet
Interventions: OTHER: The South Beach Diet|OTHER: The Ornish Diet|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dynamics and Tracer Distribution of Tilmanocept in Early Stage Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer|Sentinel Lymph Node
Interventions: DRUG: Tilmanocept|DRUG: Nanocolloid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase I Orally Administered 14C-AZD2171 in Patients With Solid Metastatic Tumors
Status: COMPLETED
Conditions: Advanced Solid Metastatic Tumor
Interventions: DRUG: AZD2171
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preemptive Analgesia With Celecoxib for Acute Dental Pain Management
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Celecoxib|DRUG: Acetaminophen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Frequency and Severity of Sleep Abnormalities in Patients With Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease|GBA Gene Mutation|Leucine-rich Repeat Kinase 2 (LRRK2) Gene Mutation
Interventions: DEVICE: Xtrodes home PSG system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Outcomes of Carbohydrate Loading Paediatric Patients Preoperatively for Tonsillectomy and Adenoidectomy
Status: UNKNOWN
Conditions: Postoperative Pain|Postoperative Nausea|Satisfaction|Sleep|Postoperative Complications
Interventions: DIETARY_SUPPLEMENT: Carbohydrate drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect Of Berry Polyphenols On Human Behaviour
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Berry Polyphenols|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bioequivalence Study for Terbinafine 250 mg
Status: COMPLETED
Conditions: Mycoses
Interventions: DRUG: Terbinafine 250 mg|DRUG: Terbinafine 250 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Prognostic Role of Indices of Sympathetic Nervous System Overdrive in MINOCA
Status: UNKNOWN
Conditions: Myocardial Infarction With Nonobstructive Coronary Arteries
Interventions: DIAGNOSTIC_TEST: MSNA|DIAGNOSTIC_TEST: Heart Rate Variability|DIAGNOSTIC_TEST: Blood Pressure Variability|DIAGNOSTIC_TEST: CMR|DIAGNOSTIC_TEST: History, Lab, clinical and hemodynamic parameters
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comparative Efficacy and Safety Study of Nexium Delayed-Release Capsules (40mg qd and 20mg qd) Versus Ranitidine 150mg Bid for the Healing of NSAID-Associated Gastric Ulcers When Daily NSAID Use is Continued in Subjects in the US Only
Status: COMPLETED
Conditions: NSAID Associated Gastric Ulcers
Interventions: DRUG: Esomeprazole|DRUG: Ranitidine|DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Establishment and Clinical Application of Pancreatic Endocrine and Exocrine Function Tests
Status: RECRUITING
Conditions: Chronic Pancreatitis|Pancreatic Exocrine Insufficiency|Diabetes Mellitus|Community Populations|Fecal Elastase-1 Test
Interventions: DIAGNOSTIC_TEST: fecal elastase-1 test|DIAGNOSTIC_TEST: 72-hour fecal fat quantification|DIAGNOSTIC_TEST: blood sample test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype|Astrocytoma, Grade III
Interventions: DRUG: Debio 0123|DRUG: Temozolomide|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit
Status: RECRUITING
Conditions: Post Traumatic Stress Disorder|Obstructive Sleep Apnea|Substance Use Disorder|Residential Treatment Program
Interventions: DEVICE: Positive Airway Pressure Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Efficacy of MUC1 Peptide Vaccine and hGM-CSF in Patients With MUC1-positive Tumor Malignancies
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: ImMucin, hGM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Augmented Reality to Reduce Pain During Botulinum Toxin Injections in Cerebral-palsied Children
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: use the module with augmented reality (Mini-Docs) on tablet during TB injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Pilot Study to Investigate the Safety and Immunologic Activity AGS-004 an Autologous HIV Immunotherapeutic Agent.
Status: COMPLETED
Conditions: HIV Seropositivity|Acquired Immunodeficiency Syndrome
Interventions: BIOLOGICAL: AGS-004
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accuracy of Guided Ridge Splitting With Simultaneous Implant Placement
Status: COMPLETED
Conditions: Dental Implant
Interventions: PROCEDURE: dental implant placement with ridge splitting.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of A Novel RinSe Device to Reduce Oral Bacteria in Intubated IntEnsive CaRe Patients: a Pilot Study
Status: RECRUITING
Conditions: Oral Bacterial Infection|Mechanical Ventilation Complication
Interventions: DEVICE: SwishKit + Oral care treatment as usual|PROCEDURE: Oral care treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Diagnostic Accuracy of Fine Needle Aspiration in Parotid Tumors
Status: UNKNOWN
Conditions: Parotid Gland Neoplasms
Interventions: PROCEDURE: aspiration biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Beta-glucan From Barley and Oats on Glucose and Lipid Metabolism, and Satiety
Status: COMPLETED
Conditions: Lipid Metabolism|Glucose Metabolism|Satiety
Interventions: DIETARY_SUPPLEMENT: Intervention 1|DIETARY_SUPPLEMENT: Intervention 2|DIETARY_SUPPLEMENT: Intervention 3|DIETARY_SUPPLEMENT: Intervention 4|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: APOS Therapy for Osteoarthritis of the Knee: a Randomized Controlled Trial BIOTOK
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: APOS shoe|DEVICE: Sham-APOS shoe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Chemotherapy With Paclitaxel, Gemcitabine, and Lapatinib (Tykerb®) (PGT)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: paclitaxel, gemcitabine, lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SYL040012, Treatment for Open Angle Glaucoma
Status: COMPLETED
Conditions: Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: 1 drop of 0.375% SYL040012 (bamosiran)|DRUG: 1 drop of 0.750% SYL040012 (bamosiran)|DRUG: 1 drop of 1.125% SYL040012 (bamosiran)|DRUG: 1 drop of 1.5% SYL040012 (bamosiran)|DRUG: 1 drop of 0.5 % timolol maleate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness Training in U.S. Army Cohorts
Status: COMPLETED
Conditions: Psychological Stress|Anxiety|Post Traumatic Stress Disorder|Depression|Cognitive Change
Interventions: BEHAVIORAL: 4-week MBAT|BEHAVIORAL: 2-week MBAT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: ImmunoTEP au 68-Ga- IMP-288 for Patients With a Recurrence of HER2 Negative Breast Carcinoma Expressing CEA
Status: COMPLETED
Conditions: HER2 Negative Breast Carcinoma Expressing CEA
Interventions: DRUG: TF2 - 68 Ga-IMP-288:
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of ARC1779 on Cerebral Microembolism in Patients Undergoing Carotid Endarterectomy
Status: TERMINATED
Conditions: Intracranial Embolism|Cerebral Thromboembolism|Carotid Stenosis
Interventions: DRUG: ARC1779 Injection|DRUG: Placebo (normal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Dexmedetomidine and Epidural Anesthesia Under General Anesthesia in Patients Undergoing Gastrectomy
Status: UNKNOWN
Conditions: Gastrectomy
Interventions: DRUG: dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dronabinol Versus Standard Ondansetron Antiemetic Therapy in Preventing Delayed-Onset Chemotherapy-Induced Nausea and Vomiting
Status: COMPLETED
Conditions: Chemotherapy Induced Nausea and Vomiting
Interventions: DRUG: dronabinol|DRUG: ondansetron|DRUG: dronabinol/ondansetron|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of ST266 in Diabetic Subjects With Deep Burns Managed With Skin Grafts
Status: TERMINATED
Conditions: Third Degree Burns|Diabetes
Interventions: BIOLOGICAL: ST266|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Open Label Study in Previously Studied, SBC-103 Treatment Naïve MPS IIIB Subjects to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics/Efficacy of SBC-103 Administered Intravenously
Status: TERMINATED
Conditions: Mucopolysaccharidosis III, Type B (MPS IIIB)|Sanfilippo B
Interventions: DRUG: SBC-103
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protocol of the Combination of Bortezomib and Tipifarnib for Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib and Tipifarnib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Clear Cell Adenocarcinoma|Endometrial Dedifferentiated Carcinoma|Endometrial Endometrioid Adenocarcinoma|Endometrial Mixed Cell Adenocarcinoma|Endometrial Serous Adenocarcinoma|Endometrial Undifferentiated Carcinoma|Recurrent Endometrial Adenocarcinoma|Recurrent Endometrial Carcinoma|Recurrent Endometrial Clear Cell Adenocarcinoma|Recurrent Endometrial Dedifferentiated Carcinoma|Recurrent Endometrial Endometrioid Adenocarcinoma|Recurrent Endometrial Mixed Cell Adenocarcinoma|Recurrent Endometrial Serous Adenocarcinoma|Recurrent Endometrial Undifferentiated Carcinoma|Stage III Uterine Corpus Cancer AJCC v8|Stage IV Uterine Corpus Cancer AJCC v8
Interventions: DRUG: Carboplatin|PROCEDURE: Computed Tomography|DRUG: Paclitaxel|BIOLOGICAL: Pembrolizumab|OTHER: Placebo Administration|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel Followed by Surgery in Treating Women With Stage II or Stage III Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: docetaxel|GENETIC: protein expression analysis|OTHER: laboratory biomarker analysis|PROCEDURE: biopsy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Lathe Cut Versus Cast Molding Soft Contact Lens Technique on Ocular Surface Integrity
Status: ACTIVE_NOT_RECRUITING
Conditions: Ocular Surface Disease
Interventions: OTHER: Soft contact lens with lathe cut technique Lathe|DIAGNOSTIC_TEST: Soft contact lens with cast molding technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Intraarticular Tranexamic Acid to Reduction of Total Blood Loss Following Knee-Arthroplasty
Status: COMPLETED
Conditions: Blood Loss|Postoperative Blood Loss|Thromboembolic Complications
Interventions: DRUG: Tranexamic Acid|DRUG: Saline water|DRUG: Tranexamic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of 611 in Chinese Children and Adolescents With Moderate to Severe Atopic Dermatitis
Status: NOT_YET_RECRUITING
Conditions: Dermatitis, Atopic
Interventions: DRUG: Recombinant Anti-interleukin-4 Receptor Alpha Monoclonal Antibody Injection (611)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-contrast Enhanced MRI in Patients With C3 Glomerulopathy (C3G) or Immune-complex Membranoproliferative Glomerulonephritis (IC-MPGN) Enrolled in the ACH471-205 Study
Status: COMPLETED
Conditions: C3 Glomerulonephritis|C3 Glomerulopathy|Immune Complex Membranoproliferative Glomerulonephritis|IC-MPGN|Dense Deposit Disease
Interventions: DEVICE: Non contrast-enhanced magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Regorafenib as a 3rd-line or Beyond Treatment for Gastrointestinal Stromal Tumors (GIST)
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumors
Interventions: DRUG: Regorafenib (Stivarga, BAY73-4506)|DRUG: Placebo|DRUG: Best supportive care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Real-Life Home Glucose Monitoring Over 14 Days in T2D Patients With Intensified Therapy Using Insulin Pump.
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DEVICE: Continuous Glucose Monitoring (CGM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Multiple Ascending Dose Study of PCSK-9 Inhibitor (IBI306) in Chinese Patients With Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: IBI306|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy (RT) and Chemotherapy for the Treatment of Pancreatic Cancer With Homologous Recombination Deficiency That Has Spread to the Liver
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer
Interventions: RADIATION: Whole liver irradiation (WLI)|DRUG: Gemcitabine and Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bronchopulmonary Function in Response to Azithromycin Treatment for Chronic Lung Disease in HIV-infected Children
Status: COMPLETED
Conditions: Chronic Lung Disease|HIV Infection
Interventions: DRUG: Azithromycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of RTA 744 in Patients With Recurrent High-Grade Gliomas
Status: COMPLETED
Conditions: Glioma
Interventions: DRUG: RTA 744|DRUG: RTA 744 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigator Initiated Trial to Evaluate the Efficacy and Safety of Intra-articular Injection of ADMSC Comared to Negative Control After High Tibial Osteotomy in the Osteoarthritis Patients.
Status: COMPLETED
Conditions: Degenerative Arthritis|Knee Osteoarthritis
Interventions: BIOLOGICAL: Autologous Adipose Tissue derived MSCs 1x10^8cells/3ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antihistamines in Eosinophilic Esophagitis
Status: TERMINATED
Conditions: Eosinophilic Esophagitis
Interventions: DRUG: Famotidine|DRUG: Loratadine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Computerized Tomographic Progression of Bone Bridging After Subtalar Fusion Using Fully and Partially Threaded Screws
Status: UNKNOWN
Conditions: Subtalar Fusion
Interventions: DEVICE: Acutrak 2® - 7.5 Screw|DEVICE: Synthes® 7.3 Cannulated Screw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy, Safety, and Tolerability of CBL-514 Injection for Reducing Subcutaneous Fat (Stage 2)
Status: COMPLETED
Conditions: Subcutaneous Fat
Interventions: DRUG: CBL-514 Injection|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Radioablation for the Treatment of Refractory Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation|Arrythmia|Cardiovascular Diseases|Heart Arrhythmia
Interventions: RADIATION: Stereotactic Radioablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eplerenone in Hemodialysis Trial
Status: COMPLETED
Conditions: Hemodialysis|End Stage Renal Disease
Interventions: DRUG: eplerenone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trientine and Carboplatin in Advanced Malignancies
Status: COMPLETED
Conditions: Advanced Cancers
Interventions: DRUG: Trientine|DRUG: Carboplatin|DRUG: Trientine MTD|DRUG: Carboplatin MTD|OTHER: PK Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of AdCLD-CoV19: A COVID-19 Preventive Vaccine in Healthy Volunteers
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: AdCLD-CoV19
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Single and Multiple Ascending Dose Study of CORT125329 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CORT125329 lipid capsule formulation|DRUG: Placebo|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Topical Treatment for Atopic Dermatitis
Status: NOT_YET_RECRUITING
Conditions: Atopic Dermatitis
Interventions: OTHER: Demonstration of applying triamcinolone cream|BEHAVIORAL: Mobile App Use|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia
Status: RECRUITING
Conditions: Hereditary Spastic Paraplegia|SPG47|SPG50|SPG51|SPG52|AP4-related Hereditary Spastic Paraplegia|Early Onset Hereditary Spastic Paraplegia|SPG4|SPG3A|SPG15|SPG11
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess the Efficacy and Safety of Rifaximin Administered BID in the Treatment of Patients With Diarrhea-Associated Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Rifaximin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Use of Prophylactic Antibiotics in Endoscopy Sinus Surgery for Chronic Rhinosinusitis With or Without Polyp
Status: UNKNOWN
Conditions: Chronic Sinus Infection
Interventions: DRUG: Amoxicillin / Clavulanic acid 875mg / 125mg|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TRANS-FOODS: Preventing Peanut Allergy Through Improved Understanding of the Transcutaneous Sensitisation Route, Novel Food Processing and Skin Care Adaptations
Status: RECRUITING
Conditions: Allergy;Food|Food Allergy Peanut|Pathways and Sources of Exposure
Interventions: OTHER: Application of the barrier enhancing preparation.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neo-adjuvant Pembrolizumab in Primary Stage IV Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer Stage IV|Peritoneal Cancer|Fallopian Tube Cancer
Interventions: DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of Naltrexone and Bupropion Combination on the Pharmacokinetics of Metformin in Healthy Participants
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Naltrexone/Bupropion|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Efficacy of Ayurved Siriraj Prasaplai for Treatment Primary Dysmenorrhea
Status: COMPLETED
Conditions: Primary Dysmenorrhea
Interventions: DRUG: Ayurved Siriraj Prasaplai with or without mefenamic acid|DRUG: Placebo with or without mefenamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT