pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Phase 2 Trial of Fluzoparib Combined With Apatinib Versus Fluzoparib Monotherapy in Treatment With Relapsed Ovarian Cancer Patients
Status: UNKNOWN
Conditions: Relapsed Ovarian Cancer
Interventions: DRUG: Fluzoparib+Apatinib|DRUG: Fluzoparib|DRUG: Fluzoparib+Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postprandial Response After Intake of Meals With Different Fatty Acid Composition
Status: COMPLETED
Conditions: Healthy|Familial Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: SFA muffin|DIETARY_SUPPLEMENT: PUFA muffin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Trauma Center-Based Intervention for Adolescent Traumatic Injury Survivors
Status: RECRUITING
Conditions: Traumatic Injury|Technology|Posttraumatic Stress Disorder|Adolescents
Interventions: BEHAVIORAL: TRRP|BEHAVIORAL: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes for Advanced HER2-Negative Breast Cancer
Status: RECRUITING
Conditions: Breast Neoplasms
Interventions: PROCEDURE: Surgery for harvesting tumor-draining lymph nodes|DRUG: Cyclophosphamide|DRUG: Fludarabine|BIOLOGICAL: Tumor-draining lymph node-derived lymphocyte (LNL)|BIOLOGICAL: Interleukin-2|BIOLOGICAL: Camrelizumab|DRUG: Chemotherapeutic drug, ADC or PARP inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Between Serratus Plane Block And Local Infiltration In Vats
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DRUG: Bupivacaine|DRUG: Bupivacaine liposome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Group Study to Evaluate the Effects of a Boric Acid Suppository on Vaginal Health.
Status: COMPLETED
Conditions: Vaginal Health|Bacterial Vaginosis
Interventions: DIETARY_SUPPLEMENT: Boric Acid Suppository
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Remimazolam on Postoperative Nausea and Vomiting
Status: RECRUITING
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Remimazolam|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: In Vivo Assessment of Endodontics Procedures
Status: UNKNOWN
Conditions: Apical Periodontitis
Interventions: PROCEDURE: TF Adaptive (First Apical Binding File)|PROCEDURE: TF Adaptive (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of LipoCol Forte® Capsules on the Pharmacokinetics of Nifedipine After Administering Single-dose Combination to Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Nifidipine & LipoCol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simple Once Daily Triple Regimen Including Tenofovir, Emtricitabine and Efavirenz in HIV-1 Infected Patients (ANRS 1207)
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: Tenofovir (TDF)|DRUG: Emtricitabine (FTC)|DRUG: Efavirenz (EFV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Eluting Balloon (DEB) vs Plain Old Balloon Angioplasty (POBA) in the Treatment of Failing Dialysis Access
Status: COMPLETED
Conditions: Vascular Diseases|Kidney Diseases
Interventions: DEVICE: Advance PTX|DEVICE: Advance LP (Low Profile)|DRUG: Paclitaxel (PTX)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate Tibolone in the Treatment of Osteoporosis (P06468)
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Tibolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label Study to Evaluate Correct Use and Ease of Use of the ELLIPTA DPI in Pediatric Subjects With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Placebo DPI|DEVICE: ELLIPTA DPI|OTHER: Ease of use questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reactogenicity, Safety and Immunogenicity of QazCovid-in® COVID-19 Vaccine
Status: COMPLETED
Conditions: Covid19|SARS-CoV Infection|Vaccine Adverse Reaction
Interventions: BIOLOGICAL: QazCovid-in® - COVID-19 inactivated vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Pinpoint Trial: Prebiotics IN Peanut Oral ImmunoTherapy
Status: RECRUITING
Conditions: Peanut Allergy
Interventions: DRUG: Prebiotic|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Multistrain Probiotic in Patients With Irritable Bowel Syndrome With Predominant Constipation
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Constipation
Interventions: DIETARY_SUPPLEMENT: Probiotics mixture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Accuracy of an Ultrasound Algorithm for Acute Dyspnea Diagnosis in the Emergency Department
Status: UNKNOWN
Conditions: Dyspnea
Interventions: PROCEDURE: Ultrasound algorithm (EMERALD-US)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Culturally Centered CBT for Latinx Youth
Status: ACTIVE_NOT_RECRUITING
Conditions: Suicide
Interventions: BEHAVIORAL: Socio-Cognitive Behavioral Therapy for Suicidal Behavior (SCBT-SB)|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Myths About Bipolar Affective Disorder: The Role of Structured Group Psychoeducation Therapy
Status: UNKNOWN
Conditions: Bipolar Affective Disorder
Interventions: BEHAVIORAL: Brief Structured Psychoeducation Group Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation and Intervention of Cognitive Function in Patients With Diabetes Mellitus.
Status: UNKNOWN
Conditions: Type2 Diabetes
Interventions: DRUG: Metformin|DRUG: Dapagliflozin|BEHAVIORAL: Lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Alendronate for Bone Mineral Density in HIV-infected Children and Adolescents
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: Alendronate|DRUG: Placebo|DIETARY_SUPPLEMENT: Calcium carbonate/vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Improve Speech Using an In-the-ear Device in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease|Dysarthria
Interventions: DEVICE: SpeechEasy Model ITC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Anchoring-tip vs. Conventional EMR of Colorectal Polyps
Status: UNKNOWN
Conditions: Colorectal Polyp
Interventions: PROCEDURE: Anchoring-tip vs. Conventional
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: SCIL-1Ra in COVID-19 Feasibility & PK/PD
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Anakinra 100Mg/0.67Ml Inj Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Trial of Ultrasound Guidance for Reduction of Pediatric Forearm Fractures
Status: TERMINATED
Conditions: Forearm Fracture|Ultrasound
Interventions: RADIATION: Ultrasound - guided fracture reduction|PROCEDURE: Standard of care fracture reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of NUC-3373 in Combination With Other Agents in Patients With Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer|Colorectal Neoplasms|Colorectal Adenocarcinoma|Colorectal Cancer Metastatic|Neoplasm, Colorectal
Interventions: DRUG: Fosifloxuridine Nafalbenamide|DRUG: Leucovorin|DRUG: Irinotecan|BIOLOGICAL: Bevacizumab|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine and Propofol for Pediatric MRI Sedation
Status: COMPLETED
Conditions: Headache|Tumor|Seizure Disorder|Neurofibromatoses|Hydrocephalus|Abdominal Neoplasm|Spine Deformity
Interventions: DRUG: propofol|DRUG: Dexmedetomidine|DRUG: Glycopyrrolate|DRUG: Lidocaine 1% Injectable Solution|DRUG: Nitrous Oxide|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Bonjesta® for Nausea and Vomiting of Pregnancy in Pregnant Adolescents
Status: RECRUITING
Conditions: Morning Sickness
Interventions: DRUG: Bonjesta|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Metabolic Predictors of Influenza Vaccine Immune Response in the Singapore Elderly Population - the DYNAMIC Trial
Status: UNKNOWN
Conditions: Influenza Vaccine|Immune Response|Elderly|Vitamin D Deficiency|Metabolic Disease|Diabetes Mellitus
Interventions: BIOLOGICAL: Influenza Vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pyrotinib Maleate Tablets Combined With Albumin Paclitaxel and Trastuzumab for Her2-positive Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer|HER2 Positive|Combination Chemotherapy
Interventions: DRUG: Pyrotinib Maleate Tablets|DRUG: Albumin Paclitaxel|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Using Dermabrasion vs CO2 Laser & Collagen Dressing vs Vaseline Gauze in MKTP
Status: UNKNOWN
Conditions: Vitiligo|Depigmented Scars|Depigmentation
Interventions: PROCEDURE: MKTP (melanocyte keratinocyte transplant procedure)|DEVICE: Collagen Dressing|DEVICE: Vaseline Impregnated Gauze|DEVICE: Carbon Dioxide Laser|DEVICE: Dermabrasion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of a Lifestyle Program on Recurrent Atrial Fibrillation
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation
Interventions: BEHAVIORAL: Multicomponent lifestyle intervention program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Lifestyle Counselling as Secondary Prevention in Patients With Minor Stroke and Transient Ischemic Attack
Status: COMPLETED
Conditions: Stroke, Ischemic|Stroke Hemorrhagic|Transient Ischemic Attack
Interventions: BEHAVIORAL: Lifestyle counselling|BEHAVIORAL: Usual care|DEVICE: Activity tracker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RATe Control in Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Metoprolol|DRUG: Diltiazem|DRUG: Verapamil|DRUG: Carvedilol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Relaxation and Intensified Patient Surgery Education in Patients Undergoing Colorectal Surgery
Status: TERMINATED
Conditions: Gastrointestinal Diseases
Interventions: BEHAVIORAL: relaxation program|BEHAVIORAL: surgery education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures
Status: NOT_YET_RECRUITING
Conditions: Tobacco Use|Cigarette Smoking|Nicotine Dependence
Interventions: OTHER: Cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Mirvetuximab Soravtansine Monotherapy in Platinum-Sensitive Epithelial, Peritoneal, and Fallopian Tube Cancers (PICCOLO)
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer|Peritoneal Cancer|Fallopian Tube Cancer
Interventions: DRUG: Mirvetuximab soravtansine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: asparaginase|DRUG: dexamethasone|DRUG: idarubicin|DRUG: methotrexate|DRUG: mitoxantrone hydrochloride|DRUG: pegaspargase|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Wet Clothing Removal Compared to Use of a Vapor Barrier in Accidental Hypothermia
Status: COMPLETED
Conditions: Accidental Hypothermia|Emergencies
Interventions: PROCEDURE: Wet clothing removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Develop Additional Safety and Clinical Experience With NATRECOR hBNP (Nesiritide) in the Treatment of Patients With Worsening Congestive Heart Failure Who Require Inpatient Intravenous Therapy With Medications That Influence the Tone and Caliber of Blood Vessels
Status: COMPLETED
Conditions: Heart Failure, Congestive|Heart Decompensation
Interventions: DRUG: nesiritide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Booster Dose of An Inactivated,Adjuvanted Whole-Virion Pandemic Influenza(H5N1)Vaccine
Status: COMPLETED
Conditions: Pandemic Influenza Vaccine|Prevention|Pandemic Influenza
Interventions: BIOLOGICAL: pandemic influenza vaccine (H5N1 strain NIBRG-14)|BIOLOGICAL: pandemic influenza vaccine (H5N1 strain NIBRG-14)|BIOLOGICAL: pandemic influenza vaccine (H5N1 strain NIBRG-14)|BIOLOGICAL: pandemic influenza vaccine (H5N1 strain NIBRG-14)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Purified Vero Rabies Vaccine-Serum Free Compared to Human Diploid Cell Vaccine in a Pre-exposure Prophylaxis Regimen
Status: COMPLETED
Conditions: Rabies
Interventions: BIOLOGICAL: Purified Vero Rabies Vaccine Serum Free (VRVg)|BIOLOGICAL: Imovax® Rabies: Human Diploid Cell Vaccine (HDCV),
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 1 Study of MPC-6827 and Carboplatin in Recurrent/Relapsed Glioblastoma Multiforme
Status: UNKNOWN
Conditions: Glioblastoma Multiforme
Interventions: DRUG: MPC-6827 + Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-arterial Bone-marrow Mononuclear Cells Infusion for Acute Ischemic Stroke
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: Autologous bone marrow mononuclear cell intra-arterial injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of BUFY02 Versus TRB02 in the Treatment of Dry Eye Disease
Status: NOT_YET_RECRUITING
Conditions: Dry Eye Disease
Interventions: DEVICE: BUFY02 eye drops in single-dose containers|DEVICE: TRB02 eye drops in single-dose containers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Robotic Modified Constraint -Induced Therapy in Patients With Spastic Hemiplegic Stroke Post Botulinum Toxin A Injection
Status: COMPLETED
Conditions: Stroke|Hemiplegia, Spastic
Interventions: OTHER: Robotic Constraint-induced movement therapy|OTHER: conventional UE rehabilitation training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of PRO-087 Versus Xyel Ofteno® and Systane Ultra®, on the Ocular Surface of Healthy Subjects
Status: COMPLETED
Conditions: Dry Eye Syndromes|Lubricant Allergy|Tear Disorder
Interventions: DRUG: PRO-087|DRUG: Systane Ultra|DRUG: Xyel Ofteno
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study on Gastro-intestinal (GI) Enteral Nutrition (EN) Tolerance in Intensive Care Unit Patients
Status: COMPLETED
Conditions: Critically Ill
Interventions: OTHER: Specific Enteral Nutrition|OTHER: Standard Enteral Nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Obinutuzumab and ICE Chemotherapy in Refractory/Recurrent CD20+ Mature NHL
Status: RECRUITING
Conditions: Non-Hodgkin Lymphoma|Burkitt Lymphoma|Diffuse Large B-Cell Lymphoma|Primary Mediastinal B-cell Lymphoma|CD20+ Lymphoblastic Lymphoma|Follicular Lymphoma, Grade III
Interventions: DRUG: Obinutuzumab|DRUG: Liposomal ARA-C|DRUG: Ifosfamide|DRUG: Carboplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Behavioral Pharmacology of Orally Administered THC and D-limonene
Status: NOT_YET_RECRUITING
Conditions: Subjective Drug Effects|THC|D-limonene
Interventions: DRUG: D-Limonene|DRUG: Delta-9-THC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of I-gel LMA, Classical LMA With a New Supraglottic Airway the Baska Mask® in Urological Surgery
Status: COMPLETED
Conditions: Airway Management
Interventions: DEVICE: LMA-C|DEVICE: Baska Mask|DEVICE: I-gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Conversion Therapy of Camrelizumab Plus Chemoradiotherapy in Participants With Initial Unresectable Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: Camrelizumab + SOX + Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy, Safety and Tolerability of CT327 in Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: CT327 ointment|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-label Pharmacokinetic Study of Diazoxide Choline Coated vs. Uncoated Formulations
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DRUG: Diazoxide choline|DRUG: Diazoxide choline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AN0025 and Pembrolizumab Combination in Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple-negative Breast Cancer|NSCLC, Squamous or Non-Squamous|Urothelial Carcinoma of the Bladder|Microsatellite Stable (MSS) Colorectal Cancer (CRC)|Cervical Cancer
Interventions: DRUG: AN0025|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Catheter-Associated Urinary Tract Infection in Incontinence and Reconstructive Pelvic Surgery Patients
Status: TERMINATED
Conditions: Catheter-Associated Urinary Tract Infection
Interventions: DRUG: Bactrim|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 1/2 Study of Amcenestrant (SAR439859) Single Agent and in Combination With Other Anti-cancer Therapies in Postmenopausal Women With Estrogen Receptor Positive Advanced Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Amcenestrant|DRUG: Palbociclib|DRUG: Alpelisib|DRUG: Everolimus|DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Predictive Value of Serum Glial Fibrillary Acidic Protein and Ubiquitin Carboxy-terminal Hydrolase L1 for Subarachnoid Haemorrhage
Status: NOT_YET_RECRUITING
Conditions: Subarachnoid Haemorrhage (SAH)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Probiotics on Oral Homeostasis During Oral Hygiene Discontinuation
Status: COMPLETED
Conditions: Gingivitis
Interventions: BEHAVIORAL: Oral hygiene discontinuation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Combination of a Cyanoacrylate and Surgical Solutions in Reducing Skin Flora Contamination
Status: COMPLETED
Conditions: Skin Flora Contamination
Interventions: PROCEDURE: InteguSeal* skin sealant and standard surgical preparation|OTHER: Standard preoperative skin preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Optimizing Anti-IL17 Antibody Therapy by Associating Fiber Supplementation to Correct Treatment-aggravated Gut Dysbiosis in Axial Spondyloarthritis - RESPOND-IL17
Status: RECRUITING
Conditions: Axial Spondyloarthritis
Interventions: DIETARY_SUPPLEMENT: Daily dietary supplementation with Fibruline|DRUG: Anti-IL-17 therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Breast Carcinoma|Metastatic Lung Non-Small Cell Carcinoma|Metastatic Malignant Neoplasm in the Leptomeninges|Stage IV Lung Cancer AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|OTHER: Electronic Health Record Review|PROCEDURE: Lumbar Puncture|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|RADIATION: Proton Beam Craniospinal Irradiation|OTHER: Survey Administration|RADIATION: Volume Modulated Arc Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metoclopramide, Azithromycin, or Nondrug Pretreatment for UGIB to Reduce Second Endoscopy
Status: UNKNOWN
Conditions: Gastro Intestinal Bleeding|Upper Gastrointestinal Bleeding
Interventions: DRUG: Azithromycin Injection|DRUG: Metoclopramide Injectable Solution|DRUG: Sodium chloride 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neurocognitive Function After Carotid Thrombendarterectomy
Status: COMPLETED
Conditions: Carotid Stenosis|Postoperative Cognitive Dysfunction|Neurological Impairment
Interventions: DEVICE: NIRS, EEG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Senobi Versus Buteyko Technique on Functional Performance of Chronic Obstructive Pulmonary Disease Patient.
Status: COMPLETED
Conditions: Shortness of Breath
Interventions: COMBINATION_PRODUCT: pursed lip breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Home-Based Diagnosis and Management of Sleep-Related Breathing Disorders in Spinal Cord Injury
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Hypercapnia|Spinal Cord Injury
Interventions: DEVICE: BiPAP|DEVICE: BiPAP/AVAPS (Phillips Respironics)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Real-World Effectiveness, Safety and Tolerability of Treatment With Apremilast in Psoriatic Arthritis Patients Followed in Canadian Routine Care (APPRAISE)
Status: COMPLETED
Conditions: Arthritis, Psoriatic
Interventions: DRUG: Apremilast
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial on the Effect of Media Multi-tasking on Attention to Food Cues and Cued Overeating
Status: COMPLETED
Conditions: Attention Concentration Difficulty|Obesity, Childhood
Interventions: BEHAVIORAL: Sustained attention|BEHAVIORAL: media multi-task|OTHER: Video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Talc Outpatient Pleurodesis With Indwelling Catheter
Status: UNKNOWN
Conditions: Pleural Effusion|Pleural Diseases|Malignant Pleural Effusion
Interventions: DEVICE: Indwelling pleural catheter placement|DRUG: Fentanyl Citrate|DRUG: Talc Slurry|DEVICE: Drainage collection bag
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methionine-Restriction Diet (MRD) in Obese Adults With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Methionine deficient diet|DIETARY_SUPPLEMENT: Methionine sufficient diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Infrared Thermography for Assessment of Caudal Block in Children
Status: COMPLETED
Conditions: Anesthesia, Conduction
Interventions: DEVICE: FLIR ONE|PROCEDURE: Regional Anesthesia - Caudal Nerve Block
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Trial to Evaluate the Efficacy and Safety of Adjunctive Therapy With Lacosamide in Adults With Partial-Onset Seizures
Status: COMPLETED
Conditions: Epilepsy|Partial Onset Seizures
Interventions: DRUG: Lacosamide 50 mg|DRUG: Lacosamide 100 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety of MM36 Topical Ointment in Pediatric Subjects With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: MM36 topical ointment, 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Futibatinib and Pembrolizumab Combination in the Treatment of Advanced or Metastatic Urothelial Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced and Metastatic Urothelial Cancer
Interventions: DRUG: futibatinib and pembrolizumab (KEYTRUDA®))
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The GRAFT Study: Gut RecolonizAtion by Fecal Transplantation
Status: COMPLETED
Conditions: Clostridium Difficile Infection|C.Difficile Diarrhea|CDI
Interventions: DRUG: Low Dose FMT Capsule DE|DRUG: Single Dose FMT Capsule DE|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of SHR-1701 Plus BP102 in Subjects With Selected Solid Tumors
Status: UNKNOWN
Conditions: Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer
Interventions: DRUG: SHR-1701；BP102
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuation of Protease-Inhibitor Based Second-Line Therapy vs. Switch to B/F/TAF in Virologically Suppressed Adults
Status: UNKNOWN
Conditions: HIV-1-infection|Antiretroviral Therapy
Interventions: DRUG: Continuation of boosted PI|DRUG: B/F/TAF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of XRP0038/NV1FGF in Critical Limb Ischemia Patients With Skin Lesions
Status: COMPLETED
Conditions: Peripheral Vascular Diseases
Interventions: BIOLOGICAL: riferminogene pecaplasmid|BIOLOGICAL: Placebo (for riferminogene pecaplasmid)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Evaluating Safety & Efficacy of DCBT: NiCord® & UNM CBU to Patients With Hematological Malignancies
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia (ALL)|Acute Myelogenous Leukemia (AML)|Myelodysplastic Syndrome (MDS)|Non-Hodgkin's Lymphoma|Hodgkin's Disease
Interventions: DRUG: NiCord®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sustainment of Mental Health Supports
Status: ENROLLING_BY_INVITATION
Conditions: Behavior Disorders
Interventions: BEHAVIORAL: Coaches with Children's Hospital of Philadelphia (CHOP) Research Consultant Support|BEHAVIORAL: Coaches without CHOP Research Consultant Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Simvastatin on Uterine Leiomyoma Development and Growth in Infertile Women
Status: UNKNOWN
Conditions: Infertility
Interventions: DRUG: oral drug and vaginal placebo|DRUG: oral drug and oral placebo|DRUG: Vaginal placebo+ oral placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using VirtuaCareTM Platform for Home Programs in Acute and Chronic Shoulder Conditions: A Pilot Study
Status: RECRUITING
Conditions: Shoulder Disease|Shoulder Injuries
Interventions: OTHER: Use of VirtuaCare™ for home program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Regional Partnership to Improve Outcomes Through Fatherhood Engagement
Status: RECRUITING
Conditions: Substance Use|Child Abuse|Child Neglect|Fathers|Father-Child Relations
Interventions: BEHAVIORAL: Motivational Enhancement|BEHAVIORAL: HERO Dads Fatherhood Program|BEHAVIORAL: Contingency Management|BEHAVIORAL: Case Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study of GlaxoSmithKline Biologicals' Human Papillomavirus (HPV) Vaccine (GSK-580299) and Merck's Gardasil Vaccine When Administered According to Alternative 2-dose Schedules in 9-14 Year Old Females
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: BIOLOGICAL: Cervarix|BIOLOGICAL: Gardasil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effectiveness of Cognitive-Functional Intervention to Reduce Driving Risk Factors of Adolescents With ADHD
Status: ACTIVE_NOT_RECRUITING
Conditions: Driving Risk Factors Among Adolescents With ADHD
Interventions: BEHAVIORAL: Drive fun|BEHAVIORAL: educational intervention|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-exposure Prophylaxis (PrEP) for Health
Status: RECRUITING
Conditions: Substance Dependence|HIV (Human Immunodeficiency Virus)
Interventions: OTHER: HIV and PrEP education|BEHAVIORAL: Motivational interviewing|BEHAVIORAL: Problem-solving and planning|BEHAVIORAL: Patient navigation|OTHER: PrEP information|OTHER: Referrals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oral Vitamin D Supplementation Combined With Phototherapy as a Treatment for Vitiligo
Status: COMPLETED
Conditions: Vitiligo|Vitiligo, Generalized|Autoimmune|Autoimmune Diseases|Autoimmune Disease Skin
Interventions: DRUG: Oral Vitamin D|PROCEDURE: NB-UVB Phototherapy|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Pentoxifylline and Celecoxib in Parkinsonism
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: carbidopa-levodopa|DRUG: Pentoxifylline 400 MG|DRUG: Celecoxib 200mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluating the Efficacy and Safety of Recombinant Long-acting Human Growth Hormone (TJ101) in Children With Growth Hormone Deficiency
Status: COMPLETED
Conditions: Pediatric Growth Hormone Deficiency
Interventions: DRUG: TJ101|DRUG: NordiFlex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Idelalisib Post Allogeneic Hematopoietic Stem Cell Transplant (HSCT) in B Cell Derived Malignancies
Status: TERMINATED
Conditions: B Cells-Tumors|B Cell Chronic Lymphocytic Leukemia|Follicular Lymphoma|Mantle Cell Lymphoma|Large B-Cell Diffuse Lymphoma of Bone (Diagnosis)
Interventions: DRUG: Idelalisib 100 MG|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Hydroxyehtyl Starch (HES) on Hemorehology, Coagulation and Elimination Kinetics
Status: COMPLETED
Conditions: Stroke Patients Presenting Within 24 Hrs of Onset of Symptoms
Interventions: DRUG: HES administration|DRUG: Hydroxy Ethyl Starch administration to stroke patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: An Explorative Study on the Pharmacokinetics and Pharmacodynamics of Sunitinib in Healthy Volunteers
Status: COMPLETED
Conditions: Blood Pressure
Interventions: DRUG: sunitinib (Sutent)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Micronutrients and Child Health Study
Status: COMPLETED
Conditions: Malaria
Interventions: DIETARY_SUPPLEMENT: Zinc|DIETARY_SUPPLEMENT: Vitamins and minerals other than zinc|DIETARY_SUPPLEMENT: Vitamins plus zinc and other minerals|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Trial of Acetazolamide Versus Placebo in Preventing Mountain Sickness During Rapid Ascent
Status: COMPLETED
Conditions: Acute Mountain Sickness
Interventions: DRUG: Acetazolamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: The Effect of Beta-blocker on Chronotropic Response and Cardiorespiratory Fitness in Patients With Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DRUG: Reduced dosage of beta-blocker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pepsinogens as the Early Marker of H. Pylori Eradication
Status: COMPLETED
Conditions: H. Pylori Infection|Gastric Ulcer|Duodnal Ulcer
Interventions: PROCEDURE: serum pepsinogen|PROCEDURE: urea breath test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetics of Eplerenone Tablet
Status: WITHDRAWN
Conditions: Healthy Volunteers
Interventions: DRUG: Eplerenone 25 mg|DRUG: Eplerenone 50 mg|DRUG: Eplerenone 100 mg|DRUG: Eplerenone 50 mg twice a day|DRUG: Eplerenone 25 mg twice a day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Assessment of Arachidonic Acid Supplementation in Infant Formula on the Immune Response of Infants
Status: COMPLETED
Conditions: Focus: Nutritional Requirements for Infants
Interventions: DIETARY_SUPPLEMENT: Arachidonic acid (25 mg/100 kcal )|DIETARY_SUPPLEMENT: Arachidonic acid (34 mg/100 kcal)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Electromyostimulation (EMS) of Astronauts in Spaceflight (Easymotion-2)
Status: NOT_YET_RECRUITING
Conditions: Muscle Atrophy|Myotonia|Stiffness; Spine|Exercise Overtraining
Interventions: DEVICE: Electromyostimulation (EMS)|DEVICE: Myoton|DIAGNOSTIC_TEST: Electromyography (EMG)|DIAGNOSTIC_TEST: Magnetic Resonance Imaging (MRI)|DIAGNOSTIC_TEST: Dynamometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Safety and Efficacy of Coronary Drug-coated Balloon (DCB) Combined With Spot Stenting of Drug-eluting Stent (DES) Versus Second-generation DES for Treating Diffuse Coronary Artery Lesions: a Prospective, Randomized, Controlled Clinical Trial
Status: UNKNOWN
Conditions: Diffuse Coronary Artery Lesions
Interventions: DEVICE: drug-coated balloon (DCB) combined with spot stenting of drug-eluting stent (DES)|DEVICE: drug-coated balloon (DCB) combined with second-generation of drug-eluting stent (DES)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Targeted Motor Learning to Improve Gait for Individuals With Parkinson Disease
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: OTHER: Gait training without rhythmic auditory cues|OTHER: TRAC|OTHER: dTRAC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Correlation Between Vitamin D and Symptoms Severity of Autonomic Nervous Mediated Syncope Child and it 's RAAS
Status: UNKNOWN
Conditions: Vitamin D
Interventions: DRUG: Vitamin D|DEVICE: Full automatic chemiluminescence measuring instrument
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pramipexole (PPX) in Moderate to Severe Idiopathic Restless Legs Syndrome (RLS) Patients
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DRUG: pramipexole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Transumbilical Single Incision Versus Conventional Laparoscopic Surgery for Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: PROCEDURE: Single incision laparoscopic surgery|PROCEDURE: Conventional laparoscopic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Nutritional Habits, Oral Hygiene, Relationship Between Dental Caries and Periodontal Condition
Status: ACTIVE_NOT_RECRUITING
Conditions: Periodontitis|MEDİTERRANEAN DİET
Interventions: BEHAVIORAL: 180 individuals who applied to the Periodontology Clinic were included in the study. Individuals were divided into 3 groups as healthy (n=60), gingivitis (n=60) and periodontitis (n=60).
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Stress Echo and Electric Impedance Tomography (EIT) Pilot Study
Status: COMPLETED
Conditions: Electric Impedance Tomography|Stress Echocardiography|Cardiac Output|Ventilation|Perfusion
Interventions: DEVICE: EIT (Electrical Impedance Tomography)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Unique Treatment of Oncology Pain in Advanced Cancer
Status: NOT_YET_RECRUITING
Conditions: Cancer Pain
Interventions: DRUG: Trichomylin® capsule (5 mg delta-9-tetrahydrocannabinol: 5 mg cannabidiol: 5 mg cannabichromene)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel and Carboplatin in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: carboplatin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Gliclazide 120 mg Modified Release Tablets
Status: WITHDRAWN
Conditions: Comparative Bioavailability
Interventions: DRUG: Gliclazide 120 mg MR Tablets Formula A|DRUG: Gliclazide 120 mg MR Tablets|DRUG: Gliclazide 120 mg MR Tablets Formula B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Lidocaine With Magnesium Sulfate on the Success of the Inferior Alveolar Nerve Block
Status: COMPLETED
Conditions: Local Anesthesia
Interventions: DRUG: use of magnesium sulfate with lidocaine in inferior alveolar nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Creation of a Probabilistic Atlas of Normal Cerebral Uptake of 18F-FDG in PET/MRI.
Status: COMPLETED
Conditions: Brain Diseases
Interventions: DIAGNOSTIC_TEST: brain PET-MRI with 18F-FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Acute Effects of E-cigarette Inhalation on Vascular Function, Microcirculation and Thrombosis
Status: COMPLETED
Conditions: E-cigarette Use|Microcirculation|Thrombosis|Vascular Function|Blood Markers|Microvesicles|NETs
Interventions: OTHER: e-cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Sleep Disordered Breathing and Its Impact on Neuro-cognitive Performance and Quality of Life in Parkinson Disease
Status: COMPLETED
Conditions: Parkinson's Disease|Sleep Disordered Breathing|Sleep Obstructive Apnea
Interventions: OTHER: Neurocognitive function|OTHER: Sleep evaluations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Improving Safety of Transitions to Skilled Nursing Care Using Videoconferencing
Status: COMPLETED
Conditions: Acute Disease
Interventions: OTHER: ECHO CT Intervention|OTHER: Matched Non-Participating Facilities
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Vancomycin Plus Moxifloxacin Versus Vancomycin Plus Ceftazidime for the Treatment of Peritoneal Dialysis (PD)-Related Peritonitis
Status: COMPLETED
Conditions: Peritoneal Dialysis Associated Peritonitis
Interventions: DRUG: vancomycin|DRUG: moxifloxacin|DRUG: ceftazidime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT