pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: RANDOMISED STUDY OF EPIDURAL VS MPCA MORPHINE VS TAPP IN LAPAROSCOPIC SIGMOIDECTOMY
Status: UNKNOWN
Conditions: Sigmoidal Tumour
Interventions: DRUG: L-BUPIVACAINE ; MORPHINE|DRUG: MORPHINE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A BHI to Increase Hope Level and Stress Level of Parents With a CMC
Status: COMPLETED
Conditions: Child With Cancer|Muscular Atrophy, Spinal|Child With Cerebral Palsy|Endocrine System Diseases
Interventions: OTHER: Brief Hope Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 71A/G HSD17B5 SNP and Effects of Oral Contraceptive Pill in PCOS Women
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: oral contraceptive pill
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RECOVER-AUTONOMIC: Platform Protocol, Appendix A (IVIG)
Status: RECRUITING
Conditions: Long COVID|Long Coronavirus Disease 2019 (Covid19)|Long Covid-19
Interventions: DRUG: IVIG (intravenous immunoglobulin)|DRUG: IVIG Placebo|BEHAVIORAL: Coordinated Care|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Exertional Dyspnea in Fibrotic Interstitial Lung Disease
Status: COMPLETED
Conditions: Lung; Disease, Interstitial, With Fibrosis
Interventions: OTHER: Room air|OTHER: Hyperoxia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Two-part, Study to Compare the Pharmacokinetics and Dose Proportionality of up to 6 Chronocort Formulations
Status: COMPLETED
Conditions: Adrenal Insufficiency|Congenital Adrenal Hyperplasia
Interventions: DRUG: Chronocort
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Placebo-Controlled Study of INS117548 Ophthalmic Solution in Subjects With Glaucoma (P08650)
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: Placebo|DRUG: INS117548|DRUG: INS117548|DRUG: INS117548
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Screening for Diabetic Retinopathy in Pharmacies With Artificial Intelligence Enhanced Retinophotography
Status: UNKNOWN
Conditions: Diabetic Retinopathy|Artificial Intelligence|Diabetes Mellitus
Interventions: DEVICE: Analysed Retinophotography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study to Assess the Safety and Tolerability of a Single Administration of FOV2302 (Ecallantide) in Patients With Macular Edema Associated With Central Retinal Vein Occlusion
Status: TERMINATED
Conditions: Macular Edema|Central Retinal Vein Occlusion
Interventions: DRUG: FOV2302 (Ecallantide)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture and Skin Temperature Behavior
Status: COMPLETED
Conditions: Thermography|Acupuncture Therapy|Electroacupuncture
Interventions: DEVICE: Acupuncture therapy and Electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Neuromodulation on Pain Biomarkers and Functional Outcome in Patients With Fibromyalgia Syndrome
Status: RECRUITING
Conditions: Fibromyalgia Syndrome
Interventions: OTHER: Aerobic Exercises|OTHER: Transcutaneous electrical nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Clinical Effects of Navarixin in Participants With Psoriasis (MK-7123-009)
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Navarixin 10 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of IBI-10090 in Patients Undergoing Cataract Surgery
Status: TERMINATED
Conditions: Inflammatory Reaction Due to Ocular Lens Prosthesis
Interventions: DRUG: IBI-10090
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Concurrent Hyperthermia and Chemoradiotherapy in LAPC: Phase II Study
Status: UNKNOWN
Conditions: Cancer Pancreas
Interventions: OTHER: Chemoradiotherapy (CTRT)|OTHER: Thermochemoradiotherapy (CTRTHT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IV Acetaminophen and Post-Tonsillectomy Pain
Status: WITHDRAWN
Conditions: Tonsillectomy|Adenoidectomy
Interventions: DRUG: Intravenous acetaminophen|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: PCRC-Supported Legacy Intervention in Pediatric Palliative Care
Status: COMPLETED
Conditions: Care Giver|Recurrent Malignant Neoplasm|Refractory Malignant Neoplasm
Interventions: OTHER: Internet-Based Intervention|OTHER: Best Practice|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Efficacy and Safety of Leflunomide or Azathioprine Therapy in Myasthenia Gravis Patients After Expand Thymectomy
Status: COMPLETED
Conditions: Myasthenia Gravis
Interventions: DRUG: Azathioprine|DRUG: Leflunomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Determine if Chromium Nicotinate Supplementation Will Improve Insulin Resistance in HIV Patients With Metabolic Abnormalities
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: chromium nicotinate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Balloon Aortic Valvuloplasty Performed Without Heparin to Decrease Vascular and Bleeding Complications of the Procedure
Status: TERMINATED
Conditions: Aortic Stenosis, Non-rheumatic
Interventions: DRUG: Heparin|DRUG: NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Protein in the Very-low-birth-weight Infant
Status: TERMINATED
Conditions: Prematurity
Interventions: OTHER: preterm infant formula with high protein levels|OTHER: preterm standard infant formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IMCY-T1D-002: Long-term Follow-up Study of T1D Patients Previously Treated With IMCY-0098 or Placebo
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: IMCY-0098 or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Registration and Treatment of Pain During Eye Examination of Prematurity
Status: TERMINATED
Conditions: Infant, Premature|Retinopathy
Interventions: DRUG: paracetamol|DRUG: sucrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tamsulosin for Urinary Retention in Hospitalized Older Women
Status: TERMINATED
Conditions: Urinary Retention
Interventions: DRUG: Tamsulosin (0.4 mg/j)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Rogaratinib (BAY1163877) vs Chemotherapy in Patients With FGFR (Fibroblast Growth Factor Receptor)-Positive Locally Advanced or Metastatic Urothelial Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Transitional Cell
Interventions: DRUG: Rogaratinib (BAY1163877)|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reconstitution With Pimecrolimus Cream 1% of Steroid-damaged Skin in Adults With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Pimecrolimus cream 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carotid IMT (Intima Media Thickening) Study (0524A-041)(TERMINATED)
Status: TERMINATED
Conditions: Hypercholesterolemia, Familial
Interventions: DRUG: Comparator: niacin (+) laropiprant (MK0524A)|DRUG: Comparator: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety & Tolerability of Multiple Dose Regimens of CHF 5074 and Exploration of Effects on Potential Markers of Clinical Efficacy in Patients With Mild Cognitive Impairment - Prolonged Open Label Extension Phase
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: CHF 5074 1x|DRUG: CHF 5074 2x|DRUG: CHF 5074 3x
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stenting vs. Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DEVICE: intracranial angioplasty and stenting|OTHER: intensive medical management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Beneficial Health Effects of an Additive-free Meat Product in Healthy Subjects (HIPOCARNE)
Status: COMPLETED
Conditions: Inflammation|Oxidative Stress|Food Toxicity
Interventions: COMBINATION_PRODUCT: Meat product without additives and allergens|COMBINATION_PRODUCT: Commercial meat product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Capecitabine and Docetaxel in Treating Patients With Recurrent or Progressive Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Capecitabine|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Symbicort Single Inhaler Therapy vs Conventional Best Practice for the Treatment of Persistent Asthma in Adults
Status: TERMINATED
Conditions: Asthma, Bronchial
Interventions: DRUG: Symbicort (budesonide/formoterol) Turbuhaler|DRUG: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PROVIDENCE - Prospective Non-interventional Study (NIS) to Examine Patient-reported Outcomes and Real-world Clinical Data in Patients With HER2-positive or HER2-low Unresectable or Metastatic Breast Cancer Treated With Trastuzumab Deruxtecan
Status: RECRUITING
Conditions: Breast Neoplasms|Breast Cancer|Neoplasm Metastasis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Integrating Palliative and Critical Care (IPACC) Study
Status: COMPLETED
Conditions: Any Disease Causing Death in the ICU or Within 24 Hours of Discharge From the ICU
Interventions: BEHAVIORAL: Education|BEHAVIORAL: Local Champions|BEHAVIORAL: Institution Feedback|BEHAVIORAL: Academic Detailing|BEHAVIORAL: Institutional Forms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Severe Alzheimer's Disease: Evaluation of Efficacy and Safety of Galantamine Hydrobromide in a Controlled Study
Status: COMPLETED
Conditions: Dementia|Alzheimer Disease
Interventions: DRUG: galantamine hydrobromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Use of a New Probiotic Strain in Couples With Fertility Problems and Dysbiosis.
Status: COMPLETED
Conditions: Infertility|Vaginal Flora Imbalance|Genital Disorder
Interventions: DIETARY_SUPPLEMENT: Lactobacillus PS11610
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Combination of Radiation Therapy and Anti-PD-1 Antibody in Treating Patients With Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: RADIATION: Radiation|DRUG: Anti-PD-1 Antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicentre Medical-economic Study Evaluating the Efficacy of Adding ZOlédronique Acid to STERéotaxique Radiotherapy in the Treatment of Vertebral Metastases
Status: UNKNOWN
Conditions: Vertebral Metastasis
Interventions: COMBINATION_PRODUCT: Zoledronic Acid 4Mg Solution for Injection + Hypo-fractured radiotherapy in stereotactic conditions|RADIATION: Hypo-fractured radiotherapy in stereotactic conditions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: DRUG: asparaginase|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: methotrexate|DRUG: therapeutic hydrocortisone|DRUG: thioguanine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AdCh63 ME-TRAP and MVA ME-TRAP Malaria Vaccines Evaluation in Healthy Children in a Malaria Endemic Area
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: AdCh63 ME-TRAP, MVA ME-TRAP|BIOLOGICAL: AdCH63 ME-TRAP, MVA ME-TRAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Characterization of Arrhythmia-induced Cardiomyopathy
Status: RECRUITING
Conditions: Cardiomyopathy|Arrhythmia-induced Cardiomyopathy (AiCM)
Interventions: OTHER: Data collection: Major adverse cardiovascular event (MACE) assessment questionnaire (prospective part)|OTHER: Data collection: Quality of Life (QoL) Questionnaire (prospective part)|OTHER: Data collection (retrospective study)|OTHER: Data collection (prospective study database)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lichtenstein Patch or Prolene Hernia System (PHS) for Inguinal Hernia Repair
Status: COMPLETED
Conditions: Chronic Pain
Interventions: PROCEDURE: Open mesh inguinal hernia repair|DEVICE: Prolene Hernia System|PROCEDURE: Lichtenstein technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Application of Annual Liver Multiscan and MRCP+ in Primary Sclerosing Cholangitis
Status: NOT_YET_RECRUITING
Conditions: Primary Sclerosing Cholangitis
Interventions: DEVICE: Liver Multiscan sequences|DEVICE: Liver Multiscan analysis|DEVICE: MRCP+
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Photodynamic and Pharmacologic Treatment of CNV
Status: COMPLETED
Conditions: Choroidal Neovascularization|Macular Degeneration
Interventions: DRUG: verteporfin (Visudyne)|DRUG: ranibizumab (Lucentis)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hip Impingement - Understanding Cartilage Damage
Status: ACTIVE_NOT_RECRUITING
Conditions: Femoroacetabular Impingement
Interventions: RADIATION: MRI|RADIATION: qCT|OTHER: Motion Analysis|RADIATION: PET-MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Sulforaphane Supplementation in Atopic Asthmatics
Status: COMPLETED
Conditions: Asthma
Interventions: DIETARY_SUPPLEMENT: Alpha Sprout Homogenate|DIETARY_SUPPLEMENT: Sulforaphane Homogenate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Identifying Gene Mutations in Patients With Melanoma and in Families With a History of Hereditary Melanoma
Status: UNKNOWN
Conditions: Hereditary Multiple Melanoma|Melanoma (Skin)
Interventions: GENETIC: gene expression analysis|GENETIC: microarray analysis|GENETIC: molecular genetic technique|GENETIC: mutation analysis|OTHER: laboratory biomarker analysis|PROCEDURE: mutation carrier screening|PROCEDURE: study of high risk factors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Evaluate the Efficacy and Safety of JW0201 Added on in Patients With Type 2 Diabetes Mellitus
Status: RECRUITING
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Treatment Period(JW0201)|DRUG: Treatment Period(Placebo)|DRUG: Extension Period(JW0201)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Anesthetics on Microcirculation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery
Status: COMPLETED
Conditions: Microcirculation|Anesthetic Complication Spinal
Interventions: DRUG: Sevoflurane|DRUG: Desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Effectiveness of Dyadic Prolonged Exposure on 2-4 Years Old vs. Toddler-parent Focused Treatment
Status: TERMINATED
Conditions: Post-Traumatic Stress Disorder in Children
Interventions: BEHAVIORAL: Prolonged exposure|BEHAVIORAL: Child-parent Play Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: N-Acetylcysteine in Critically Ill Patients Undergoing Contrast Enhanced Computed Tomography
Status: COMPLETED
Conditions: Contrast Induced Nephropathy|Critically Ill
Interventions: DRUG: N-acetylcysteine|DRUG: D5W Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Impact of Mobile Phone Messages on ART and PMTCT Adherence in Mozambique
Status: COMPLETED
Conditions: HIV-positive
Interventions: BEHAVIORAL: SMS reminders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative and Additive Diagnostic Performance of Magnetic Resonance Elastography (MRE) and Corrected-T1 (cT1) for Fibrosis and Inflammation in Nonalcoholic Steatohepatitis (NASH) Using Histology as Reference
Status: RECRUITING
Conditions: Nonalcoholic Fatty Liver|Nonalcoholic Steatohepatitis|Liver Fibroses|Liver Inflammation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of a Dried Vegetable on Bowel Function and Gut Microbiota
Status: UNKNOWN
Conditions: Bowel Function Dissatisfaction
Interventions: DIETARY_SUPPLEMENT: Dried chicory root particles|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 2 Study of MD-1100 Acetate on Gastrointestinal Transit in Patients With C-IBS
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: MD-1100 Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Safety and Efficacy of Intravenous Iron Versus Oral Iron in the Treatment of Anemia Secondary to Heavy Uterine Bleeding
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Ferric Carboxymaltose (FCM)|DRUG: Ferrous Sulfate tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VALTREX(Valacyclovir) Once Daily for Viral Shedding In Subjects Newly Diagnosed With HSV-2
Status: COMPLETED
Conditions: Herpes Labialis
Interventions: DRUG: valacyclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ruxolitinib for Acute Respiratory Disorder Syndrome Due to COVID-19
Status: TERMINATED
Conditions: Severe Acute Respiratory Syndrome Coronavirus 2|SARS-CoV2
Interventions: DRUG: Janus Kinase Inhibitor (ruxolitinib)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Eye Health Benefits of Black Tomato Extract
Status: RECRUITING
Conditions: Eye|High Myopia
Interventions: DIETARY_SUPPLEMENT: Black tomato extract powder|DIETARY_SUPPLEMENT: Placebo powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Partially HLA Mismatched (Haploidentical) Allogeneic Bone Marrow Transplantation
Status: TERMINATED
Conditions: Hematologic Malignancies
Interventions: PROCEDURE: Haploidentical Transplant|DRUG: Fludarabine|DRUG: Busulfan|RADIATION: Total Body Irradiation|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The University of Alabama at Birmingham (UAB) Neuroinflammation in Parkinson's Disease-TSPO- Positron Emission Tomography (PET) Substudy
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: DPA-714-PET/MRI|DRUG: 5-year Follow-up DPA-714-PET/MRI|DRUG: DPA-714 Metabolite Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Purified Umbilical Cord Blood CD34+ Stem Cell on Chronic Ischemic Stroke
Status: UNKNOWN
Conditions: Ischemic Stroke|Ischaemic Cerebral Infarction|Infarction, Middle Cerebral Artery|Ischemia|Brain Ischemia
Interventions: PROCEDURE: Intercerebral implantation of allogenic CD34+ stem cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of 2 Immunomodulator Withdrawal Schemes for Infliximab Monotherapy in Active Pediatric Crohn's Disease After Thiopurine Failure
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: DRUG: AZATHIOPRINE or METHOTREXATE|DRUG: AZATHIOPRINE or METHOTREXATE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet-based Video-conferencing to Address Alcohol Use and Pain: a Pilot Trial
Status: COMPLETED
Conditions: Alcohol Drinking and Chronic Pain Intervention|Control Condition
Interventions: BEHAVIORAL: Motivational and Cognitive-Behavioral Management for Alcohol and Pain (MCBMAP)|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Osmotic Laxatives Versus Macrogol for Bowel Preparation in Patients Undergoing Colonoscopy
Status: UNKNOWN
Conditions: Colorectal Disorders
Interventions: DRUG: Eziklen®|DRUG: MoviPrep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ceftaroline Diffusion Into Cerebrospinal Fluid of Children
Status: UNKNOWN
Conditions: Cerebrospinal Fluid Shunts|Ventriculoperitoneal Shunt
Interventions: DRUG: Ceftaroline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of 2% Chlorhexidine-70% Isopropanol vs 5% Povidone Iodine-69% Ethanol for Skin Antisepsis in Reducing Surgical-site Infection After Cardiac Surgery
Status: COMPLETED
Conditions: Cardiac Surgery in Adult Patient
Interventions: DRUG: 2%Chlorhexidine-70%Isopropanol|DRUG: 5%Povidone Iodine- 69%Ethanol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Treatment Pegylated Liposomal Doxorubicin Plus Cyclophosphamide Sequential Docetaxel Plus Trastuzumab and Pertuzumab Versus Docetaxel Plus Carboplatin Combined With Trastuzumab and Pertuzumab in HER-2 Positive Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: pegylated liposomal doxorubicin (PLD)|DRUG: cyclophosphamide (C)|DRUG: trastuzumab (H)|DRUG: pertuzumab (P)|DRUG: docetaxel (T)|DRUG: docetaxel (T)|DRUG: carboplatin (Cb)|DRUG: trastuzumab (H)|DRUG: pertuzumab (P)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Stepped Wedge Cluster Randomized Controlled Trial to Assess a Strategy Aiming to Optimize Psychosocial Outcomes in Patients With Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: BEHAVIORAL: HQIS implementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Prospective Trial of Cooled Radiofrequency Ablation of Medial Branch Nerves Versus Facet Joint Injection of Corticosteroid for the Treatment of Lumbar Facet Syndrome
Status: COMPLETED
Conditions: Lumbar Facet Syndrome
Interventions: PROCEDURE: Cooled Radiofrequency Ablation of Medial Branch Nerves versus Facet Joint Injection of Corticosteroid for the Treatment of Lumbar Facet Syndrome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alternative Options to Minimize Niacin-Induced Flushing
Status: COMPLETED
Conditions: Hypercholesterolemia|Flushing
Interventions: OTHER: Apple pectin|DRUG: Aspirin 325 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 5% Lidocaine-medicated Plaster for the Treatment of Trigeminal Neuralgia
Status: COMPLETED
Conditions: Trigeminal Neuralgia
Interventions: DRUG: 5% lidocaine medicated plaster|DRUG: vehicle plaster
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Gait Rehabilitation With Motor Imagery in People With Parkinson's Disease
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: OTHER: Physical rehabilitation of gait with motor imagery|OTHER: Physical rehabilitation of gait without motor imagery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Screening for Coronary Artery Disease USing Primary Evaluation With Coronary CTA in Aviation Medicine (SUSPECT)
Status: TERMINATED
Conditions: Coronary Artery Disease (CAD)|Coronary Artery Calcification|Occupational Diseases|Aviator's; Disease
Interventions: RADIATION: CT Angiography|DIAGNOSTIC_TEST: Exercise stress test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Use of Sublingual Microcirculation and FloTrac Monitoring During Major Vascular Surgery and Its Effect on Hospital LOS
Status: ACTIVE_NOT_RECRUITING
Conditions: Carotid Artery Plaque|Aortic Aneurysm|Aneurysm
Interventions: PROCEDURE: Cytocam-IDF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of the PCSK9 Inhibitor AK102 in Patients With HoFH
Status: COMPLETED
Conditions: Homozygous Familial Hypercholesterolemia
Interventions: DRUG: AK102|DRUG: Statins|DRUG: Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of Microprocessor Controlled and Carbon Fiber Prosthetic Feet in Transtibial Amputees
Status: COMPLETED
Conditions: Amputation
Interventions: DEVICE: Kinnex|DEVICE: Pacifica LP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of Inhaled MBS-COV (SNS812) in Healthy Participants
Status: COMPLETED
Conditions: Disease Caused by Severe Acute Respiratory Syndrome Coronavirus 2 (Disorder)
Interventions: DRUG: MBS-COV|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effects of Daridorexant on Nighttime Breathing in Patients With Shallow or Paused Breath During Sleep
Status: COMPLETED
Conditions: Obstructive Sleep Apnea of Adult
Interventions: DRUG: Daridorexant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Correction of Zinc Deficiency in Children With Chronic Kidney Disease and Kidney Transplant
Status: COMPLETED
Conditions: Renal Insufficiency, Chronic|Zinc Deficiency|Trace Element Excess|Trace Element Deficiency
Interventions: DRUG: Zinc Supplement|PROCEDURE: Repeat blood and urine tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Rhythmic Auditory Cueing During Bilateral Training of the Upper Extremities in Stroke Patients
Status: COMPLETED
Conditions: Hemiplegia, Spastic
Interventions: OTHER: Rhythmic Auditory Cueing|OTHER: Bilateral arm training|OTHER: Conventional physical therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Angiomax to Heparin With Protamine Reversal in Patients OPCAB
Status: COMPLETED
Conditions: Cardiac Surgery|Coronary Artery Bypass Surgery
Interventions: DRUG: Bivalirudin|DRUG: Heparin|DRUG: Protamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remineralizing Efficacy of Grape Seed Extract in Management of White Spot Lesion in Post Orthodontic Treated Patients.
Status: UNKNOWN
Conditions: Dental Caries
Interventions: OTHER: Grape seed extract mouthwash|OTHER: Sodium fluoride mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lumbar Stenosis Outcomes Research II
Status: TERMINATED
Conditions: Lumbar Spinal Stenosis
Interventions: DRUG: opana then darvocet then placebo|DRUG: opana then placebo then darvocet|DRUG: placebo then opana then darvocet|DRUG: Placebo then darvocet then opana|DRUG: Darvocet then opana then placebo|DRUG: Darvocet then placebo then opana
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel in Treating Patients With Persistent or Recurrent Cervical Cancer
Status: COMPLETED
Conditions: Cervical Squamous Cell Carcinoma, Not Otherwise Specified|Recurrent Cervical Carcinoma
Interventions: DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Super High-Flux - High Volume Dialysis in Sepsis-Induced Acute Renal Failure
Status: COMPLETED
Conditions: Sepsis|Acute Renal Failure
Interventions: DEVICE: Large pore dialyser|DEVICE: Standard dialyser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Muscles in Liver Diseases
Status: NOT_YET_RECRUITING
Conditions: Patients Having a Scheduled Abdominal Surgery Procedure
Interventions: OTHER: blood samples|OTHER: biopsy of abdominal paroie
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Difluprednate in the Treatment of Inflammation Following Ocular Surgery (ST-601-004)
Status: COMPLETED
Conditions: Inflammation
Interventions: DRUG: Difluprednate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial of Structured Stepped-care Intervention for Psychiatric Comorbidity
Status: COMPLETED
Conditions: Alcohol Dependence|Anxiety|Depression
Interventions: BEHAVIORAL: Integrated care|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Less Pain in Neonates During Central Lines Insertion
Status: COMPLETED
Conditions: Central Venous Catheter|Neonates|Pain
Interventions: PROCEDURE: Ultrasound Guided Central Catheter Insertion|PROCEDURE: Peripherally Inserted Central Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Topical Metformin Emulgel VS Salicylic Acid Peeling in Treatment of Acne Vulgaris
Status: UNKNOWN
Conditions: Acne Vulgaris
Interventions: DRUG: Topical Metformin Emulgel and salicylic acid|DIAGNOSTIC_TEST: Insulin- Like growth factor (ILGF-1)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacodynamics of SEL-068 Vaccine in Smokers and Non-Smokers
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BIOLOGICAL: SEL-068|BIOLOGICAL: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CentriMag Ventricular Assist System in Treating Failure-to-Wean From Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Heart Failure
Interventions: DEVICE: CentriMag Ventricular Assist System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise Training and Manual Wheelchair Users With SCI
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: BEHAVIORAL: Roller-based Intervention Group (IG)|BEHAVIORAL: Control Group (CG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Endometrial Injury in Couples With Unexplained Infertility
Status: UNKNOWN
Conditions: Unexplained Infertility
Interventions: DRUG: Clomiphene Citrate|DRUG: Human chorionic gonadotropin|DEVICE: Endometrial scratch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Driving Pressure-guided PEEP Titration in Robot-assisted Laparoscopic Surgeries
Status: COMPLETED
Conditions: Atelectasis, Postoperative Pulmonary
Interventions: PROCEDURE: Titrated PEEP based on driving pressure|PROCEDURE: Conventional PEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Relative Bioavailability of New Oral Formulations of SRT2104 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Cap SRT2104|DRUG: Tab SRT2104 slow release|DRUG: Tab SRT2104 intermediate release|DRUG: Tab SRT2104 fast release|DRUG: Selected formulations of SRT2104 from Part 1|DRUG: Selected formulations of SRT2104 from Part 1 single alternative dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bioequivalence Study of Montelukast, 5 mg Chewable Tablets (Pharmtechnology LLC, Belarus), and Singulair®, 5 mg Chewable Tablets (Merck Sharp & Dohme B.V., the Netherlands), in Healthy Volunteers Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DRUG: Montelukast|DRUG: Singulair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Phase 1 Ascending and Parallel Group Trial to Establish the Safety, Tolerability and Pharmacokinetics Profile of Volociximab (Alpha 5 Beta 1 Integrin Antagonist) in Subjects With Neovascular Age- Related Macular Degeneration
Status: COMPLETED
Conditions: Age-related Macular Degeneration
Interventions: DRUG: volociximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subanalysis in Patients With CARDIoLAMinopathy Enrolled to REPORT-CCM Registry
Status: UNKNOWN
Conditions: Laminopathy|Lamin A/C Gene Mutation|Heart Failure
Interventions: DEVICE: Implant of the device for Cardiac Contractility Modulation (CCM) Therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of a Speech-Language Assessment Tool for Pragmatic and Discourse Skills in Schizophrenia Spectrum Disorders
Status: COMPLETED
Conditions: Psychotic Disorders
Interventions: DIAGNOSTIC_TEST: Measurement of pragmatic and discourse test scores in the two scales.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparing Pressure Based and Dilution Based Total Lung Capacity Measurements in COPD Patients for Lung Function Diagnostics
Status: COMPLETED
Conditions: COPD
Interventions: DEVICE: Respiratory Analysis System|DEVICE: Respiratory Analysis System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Early Blood Pressure Management in Extremely Premature Infants
Status: COMPLETED
Conditions: Infant, Newborn|Infant, Low Birth Weight|Infant, Small for Gestational Age|Infant, Premature|Hypotension|Blood Pressure
Interventions: DRUG: Dopamine|DRUG: Hydrocortisone|DRUG: Infusion Placebo|DRUG: Syringe Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab and Vicineum in Subjects With High-Grade Non-Muscle-Invasive Bladder Cancer Previously Treated With Bacillus Calmette-Guerin (BCG)
Status: COMPLETED
Conditions: Urinary Bladder Neoplasms
Interventions: DRUG: Durvalumab|DRUG: Vicineum|DRUG: Acetaminophen|DRUG: Antihistamine|PROCEDURE: Bladder Biopsy|PROCEDURE: TURBT|PROCEDURE: Cystoscopy|DIAGNOSTIC_TEST: Urine cytology|DIAGNOSTIC_TEST: Electrocardiogram|DIAGNOSTIC_TEST: CT|DIAGNOSTIC_TEST: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cornea Preservation Time Study
Status: COMPLETED
Conditions: Cornea Preservation Time|Endothelial Keratoplasty|Transplant Success|Endothelial Cell Density
Interventions: BIOLOGICAL: Cornea tissue transplant|BIOLOGICAL: Cornea tissue transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Can the Health Benefits of a Walking-based Exercise Programme be Enhanced by Co-ingestion of a Lipid-lowering Drug?
Status: COMPLETED
Conditions: Pre-diabetes
Interventions: OTHER: Exercise Program|DIAGNOSTIC_TEST: DXA|DIAGNOSTIC_TEST: MRI|DIAGNOSTIC_TEST: Hyperinsulinaemic Euglycaemic Clamp|DIAGNOSTIC_TEST: VO2 Max|DIAGNOSTIC_TEST: Continuous Glucose Monitor|PROCEDURE: Muscle Biopsies|DRUG: Acipimox 250 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)
Status: COMPLETED
Conditions: Non-arteritic Anterior Ischemic Optic Neuropathy
Interventions: DRUG: Group A Citicoline 1000 mg oral tablet|DRUG: Group B placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Duloxetine Versus Placebo in the Treatment of Patients With Diabetic Peripheral Neuropathic Pain in China
Status: COMPLETED
Conditions: Diabetic Neuropathies
Interventions: DRUG: Duloxetine Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Telitacicept in Subjects With Active Primary Sjogren's Syndrome
Status: RECRUITING
Conditions: Primary Sjogren's Syndrome
Interventions: BIOLOGICAL: Telitacicept 80 mg|BIOLOGICAL: Telitacicept 160 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A New Care Model for Patients With Complicated Multimorbidity
Status: RECRUITING
Conditions: Multimorbidity
Interventions: OTHER: Patient-centred complex intervention in complicated multimorbidity (CIM2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Triage and Treatment of Atypical Glandular Cells (AGC) Detected in Screening
Status: ENROLLING_BY_INVITATION
Conditions: Uterine Cervical Cancer
Interventions: PROCEDURE: Conization|PROCEDURE: Colposcopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Enhancing the Effects of Alcohol Treatment With Lamotrigine
Status: RECRUITING
Conditions: Alcohol Use Disorder
Interventions: DRUG: Lamotrigine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae vs TAP in Lower Abdominal Surgery
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: PROCEDURE: lower abdominal surgery|OTHER: Erector spinae plane block|OTHER: Transversus abdominis plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nitroglycerin Prevents Radial Artery Occlusion
Status: COMPLETED
Conditions: Injury of Radial Artery
Interventions: DRUG: 500 microgram of Nitroglycerin|DRUG: Saline 5 mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Neural Correlates of Cognition in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: Computer task assessing cognition|BEHAVIORAL: Impulsive-Compulsive Disorders in Parkinson's Disease|PROCEDURE: Deep Brain Stimulation Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Yoga on Cardiac Sympathetic Innervation Evaluated by I-123 mIBG
Status: WITHDRAWN
Conditions: Heart Failure, Systolic
Interventions: BEHAVIORAL: Yoga training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Social Norms and Antihypertensive Medication Adherence
Status: WITHDRAWN
Conditions: Hypertension|Medication Adherence
Interventions: BEHAVIORAL: Financial reward|BEHAVIORAL: Social norms|DEVICE: Home Blood Pressure Monitoring|DEVICE: Medication adherence assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH