pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Acute Exposure to High Altitude on Pulmonary Artery Pressure and Right Heart Function (Echo) Under Exercise
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: OTHER: Assessment at Low Altitude (470m above sea level)|OTHER: Exposure to High Altitude (2500m above sea level)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Pivotal Study to Evaluate the Safety and Effectiveness of RMT Medical Technology's SafeFlo® Vena Cava Filter
Status: COMPLETED
Conditions: Pulmonary Embolism
Interventions: DEVICE: SafeFlo IVC Filter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Magnetic Resonance Spectroscopic Imaging of the Prostate at 3 Tesla
Status: COMPLETED
Conditions: Prostate Cancer|MRI
Interventions: OTHER: Magnetic Resonance Imaging; Spectroscopic Imaging, Contrast Enhanced Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ixekizumab for the Management of Refractory Non-Infectious Uveitis: A Proof-of-Concept Study
Status: RECRUITING
Conditions: Uveitis, Posterior|Uveitis, Anterior|Uveitis, Intermediate|Panuveitis
Interventions: DRUG: Ixekizumab Prefilled Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety of Asasantin Extended Release (RAD-SP) Capsules in Japanese Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Asasantin®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study Investigating the Effect of 4 Doses of RPL554 Given in Addition to Tiotropium to Patients With COPD
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Ensifentrine (formerly RPL554) 0.375 mg twice daily plus placebo, in addition to tiotropium|DRUG: Ensifentrine (formerly RPL554) 0.75 mg twice daily plus placebo, in addition to tiotropium|DRUG: Ensifentrine (formerly RPL554) 1.5 mg twice daily plus placebo, in addition to tiotropium|DRUG: Ensifentrine (formerly RPL554) 3.0 mg twice daily plus placebo, in addition to tiotropium|DRUG: Ensifentrine (formerly RPL554) placebo twice daily, in addition to tiotropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Everyday Memory Impairment in PD-related Cognitive Decline
Status: ENROLLING_BY_INVITATION
Conditions: Parkinson Disease|Mild Cognitive Impairment
Interventions: BEHAVIORAL: Strategy Training (Time- and Event- Based)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Free Fatty Acids and Vascular Function in Subjects With Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: acipimox|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GEMINI Study - A Study of Saquinavir/Ritonavir in Treatment-Naive Patients With HIV-1 Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: saquinavir [Invirase]|DRUG: Lopinavir/ritonavir|DRUG: Emtricitabine/tenofovir disoproxil fumarate|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial on Safety and Efficacy of Velmanase Alfa Treatment in Pediatric Patients With Alpha-Mannosidosis
Status: COMPLETED
Conditions: Alpha-Mannosidosis
Interventions: DRUG: Velmanase Alfa (e.g. Lamazym)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Dosage in MicroPulse TransScleral CycloPhotocoagulation
Status: TERMINATED
Conditions: Glaucoma
Interventions: PROCEDURE: MicroPulse TransScleral CycloPhotoCoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Longitudinal Study of Local Ablative Therapy in Oligometastatic Disease
Status: RECRUITING
Conditions: Oligometastatic Disease|Metastases|Ablation Techniques|Radiotherapy|Stereotactic Radiation|Surgery
Interventions: PROCEDURE: Local ablative therapy (LAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Zilovertamab and Ibrutinib in Patients With Relapsed or Refractory Mantle Cell Lymphoma
Status: WITHDRAWN
Conditions: Lymphoma, Mantle-Cell|Lymphoma|Lymphoproliferative Disorders|Lymphatic Diseases|Immunoproliferative Disorders|Immune System Diseases|Lymphoma, Non-Hodgkin|Lymphoma, B-Cell
Interventions: DRUG: Zilovertamab|DRUG: Ibrutinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Arch Bars vs. IMF (Intermaxillary Fixation) Screws: Cost Effectiveness Based on Time Duration of Device Placement.
Status: TERMINATED
Conditions: Mandible Fracture
Interventions: DEVICE: IMF Screws|DEVICE: Erich Arch Bars
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Gargle Containing Honeysuckle and Semen Oroxyli
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Complication|Pain
Interventions: DRUG: honeysuckle and semen oroxyli solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetic Susceptibility and Influence of the Microbiomae in Bullous Pemphigoid
Status: UNKNOWN
Conditions: Bullous Pemphigoid
Interventions: OTHER: Blood sample and cotton skin swabs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis
Status: COMPLETED
Conditions: Acute Cholecystitis
Interventions: DRUG: Amoxicillin clavulanic|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Expanded Access Study of Pegasys (Peginterferon Alfa-2a) in Patients With HBeAg-Negative Chronic Hepatitis B
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Peginterferon alfa-2a [Pegasys]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Filgrastim Before Surgery in Treating Patients With HER2-Positive Breast Cancer That Can Be Removed By Surgery
Status: COMPLETED
Conditions: Estrogen Receptor-negative Breast Cancer|Estrogen Receptor-positive Breast Cancer|HER2-positive Breast Cancer|Progesterone Receptor-negative Breast Cancer|Progesterone Receptor-positive Breast Cancer|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer
Interventions: DRUG: doxorubicin hydrochloride|DRUG: cyclophosphamide|DRUG: paclitaxel|BIOLOGICAL: filgrastim|DRUG: capecitabine|DRUG: methotrexate|DRUG: vinorelbine tartrate|PROCEDURE: needle biopsy|PROCEDURE: therapeutic conventional surgery|OTHER: immunohistochemistry staining method|BIOLOGICAL: trastuzumab|DRUG: tamoxifen citrate|DRUG: letrozole|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of HRS-8080 or SHR-A2009 Combined With Anti-tumor Therapy in Patients With Unresectable or Metastatic Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: HRS-8080; SHR-A1811|DRUG: HRS-8080; SHR-A2009|DRUG: SHR-A2009; SHR-1316
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing and Improving the Durability of Compensatory Cognitive Training for Older Veterans
Status: ENROLLING_BY_INVITATION
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Motivationally-Enhanced Compensatory Cognitive Training (ME-CCT) Booster Modules|OTHER: Treatment As Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Retinal Neuro-vascular Coupling in Patients With Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis, Relapsing-Remitting|Optic Neuritis
Interventions: DEVICE: Dynamic Vessel Analyzer (DVA)|DEVICE: Fourier Domain Doppler Optical Coherence Tomography (FDOCT)|DEVICE: Optical coherence tomography (OCT)|DEVICE: Optical coherence tomography angiography (OCTA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Clamshell Exercise on Lumbopelvic Stability and Low Back Pain in Post Partum Women
Status: NOT_YET_RECRUITING
Conditions: Lumbosacral Instability|Low Back Pain Post Partum
Interventions: OTHER: Abdominal bracing|OTHER: clamshell exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NIRS in Congenital Heart Defects - Correlation With Echocardiography
Status: RECRUITING
Conditions: Congenital Heart Defect|Single-ventricle|Coarctation of Aorta|Atrioventricular Canal|Hypoplastic Left Heart|Transposition of Great Vessels|Interrupted Aortic Arch|Tricuspid Atresia|Pulmonary Atresia|Aortic Atresia|Tetralogy of Fallot
Interventions: DEVICE: NIRS evaluation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioavailability of Encapsulated Omega-3 Fatty Acids
Status: COMPLETED
Conditions: Bioavailability of Omega-3s in Military Rations
Interventions: DIETARY_SUPPLEMENT: encapsulated 600 mg EPA/DHA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Impact of Bacterial Expression and Immune Response in the Severity of Pertussis
Status: RECRUITING
Conditions: Bordetella Pertussis, Whooping Cough
Interventions: BIOLOGICAL: Nasopharyngeal swab|BIOLOGICAL: Blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: AZD2423 Safety and Tolerability Study in Patients With Moderate and Severe Chronic Obstructive Pulmonary Disease(COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Lung Disease
Interventions: DRUG: AZD2423|DRUG: Placebo to AZD2423
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Growth Hormone During Fasting.Signaltransduktion in Muscle and Adipose Tissue and Changes in Intrahepatic Lipid Content
Status: COMPLETED
Conditions: Metabolism|Fatty Liver
Interventions: DRUG: Somatropin and pegvisomant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Resilience for Children and Young People in Foster Care and Residential Care in Denmark
Status: UNKNOWN
Conditions: Children and Adolescents in Foster Care and Residential Care
Interventions: BEHAVIORAL: The Resilience Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Trial For Early SARS-CoV-2 (COVID-19) Treatment
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Hydroxychloroquine|DRUG: Favipiravir|DRUG: Favipiravir + Hydroxychloroquine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Myeloablative Hematopoietic Progenitor Cell Transplantation (HPCT) for Pediatric Malignancies
Status: UNKNOWN
Conditions: Leukemia, Myelogenous, Chronic|Leukemia, Lymphoblastic, Acute|Leukemia, Myelogenous, Acute|Myeloproliferative-Myelodysplastic Diseases|Lymphoma, Malignant
Interventions: DRUG: Myeloablative Chemotherapy Regimen for Lymphoid Malignancies or Cord Blood Unit Recipients|DRUG: Myeloablative Chemotherapy Regimen for Non-Cord Blood Unit Recipients with Myeloid Malignancies|OTHER: Hematopoietic Progenitor Cell Transplantation (HPCT)|RADIATION: CNS radiation treatment for ALL with prior CNS disease patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block Versus Subcostal Transversus Abdominis Plane Block in Open Liver Resection Surgery
Status: UNKNOWN
Conditions: Analgesia|Hepatic Resection Surgery
Interventions: OTHER: subcostal transversus plane block|OTHER: erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluate the Safety and Tolerability of Vandetanib in Japanese Patients With Medullary Thyroid Carcinoma
Status: COMPLETED
Conditions: Unresectable Locally Advanced or Metastatic, Medullary Thyroid Carcinoma
Interventions: DRUG: Vandetanib 300mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of High-fat Meals Varying in Fatty Acid Composition on Adipose and Systemic Metabolic-inflammatory Responses
Status: COMPLETED
Conditions: Inflammation|Obesity|Inflammatory Response|Cardiovascular Diseases|Overweight
Interventions: DIETARY_SUPPLEMENT: SFA-Rich Meal|DIETARY_SUPPLEMENT: MUFA-Rich Meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Effects of Giving Two Anti-HIV Vaccines to Babies of HIV-Positive Mothers
Status: COMPLETED
Conditions: HIV Infections|HIV Seronegativity
Interventions: BIOLOGICAL: ALVAC(2)120(B,MN)GNP (vCP1452)|BIOLOGICAL: MN rgp120/HIV-1 and GNE8 rgp120/HIV-1|BIOLOGICAL: ALVAC-HIV MN120TMG (vCP205)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Management of Patients With Type 2 Diabetes and Hypertension Using Mobile Health Care System
Status: COMPLETED
Conditions: Diabetes|Hypertension|Obesity
Interventions: DEVICE: Mobile Health Care System (DrUB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of High-Dose Chemoradiation Using Biologically-Based Target Volume Definition in Patients With Glioblastoma
Status: COMPLETED
Conditions: Glioma
Interventions: RADIATION: High Dose Radiation|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study on the Safety and Tolerability of Gadobutrol (Gadovist) Among Filipino Patients in Magnetic Resonance Imaging
Status: COMPLETED
Conditions: Magnetic Resonance Imaging
Interventions: DRUG: Gadobutrol (Gadovist, BAY86-4875)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Relative Bio-availability of Oral and Oromucosal Melatonin in Different Formulations in Healthy Human Volunteers.
Status: COMPLETED
Conditions: Pharmacokinetics of Melatonin
Interventions: DRUG: Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neo-adjuvant FOLF(IRIN)OX for Resectable Pancreatic Adenocarcinoma
Status: UNKNOWN
Conditions: Resectable Pancreatic Duct Adenocarcinoma
Interventions: DRUG: FOLFOX neoadjuvant chemotherapy|DRUG: FOLFIRINOX neoadjuvant chemotherapy|PROCEDURE: curative surgery for resectable pancreatic duct adenocarcinoma|DRUG: Standard adjuvant chemotherapy|DRUG: adjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc
Status: RECRUITING
Conditions: Glioblastoma Multiforme
Interventions: DRUG: CAR.B7-H3T cells infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight
Status: RECRUITING
Conditions: Type 2 Diabetes|Obesity|Overweight|Obstructive Sleep Apnea
Interventions: DRUG: Retatrutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment for Patients With Non-Small Cell Lung Cancer Who Developed Anemia Due to Chemotherapy
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer|Anemia
Interventions: DRUG: darbepoetin alfa|DRUG: recombinant human erythropoietin (rHuEPO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of a Nurse-led Case Management Programme on Home Exercise Training for Haemodialysis Patients
Status: COMPLETED
Conditions: Kidney Disease
Interventions: BEHAVIORAL: Nurse-led interviewing|OTHER: Brief group exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Assessment of Safety and Immunogenicity of a Single Vial Presentation of R21/Matrix-M and Co-Administration With EPI Vaccines
Status: ACTIVE_NOT_RECRUITING
Conditions: Malaria
Interventions: BIOLOGICAL: R21/Matrix-M - single vial formulation|BIOLOGICAL: R21/Matrix-M - two vial formulation|BIOLOGICAL: Licensed vaccine - Measles-rubella|BIOLOGICAL: Licensed vaccine - Yellow fever|BIOLOGICAL: Licensed vaccine - Pentavalent (diphtheria, tetanus, pertussis, hepatitis B and Hib)|BIOLOGICAL: Licensed vaccine - Oral Polio Vaccine (OPV)|BIOLOGICAL: Licensed vaccine - Rotavirus|BIOLOGICAL: Licensed vaccine - Pneumococcal vaccine|BIOLOGICAL: Licensed vaccine - Inactivated Polio Vaccine (IPV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: NANOS Neck Preserving Hip Stem
Status: TERMINATED
Conditions: Primary Osteoarthritis|Secondary Osteoarthritis|Dysplasia Osteoarthritis|Avascular Femoral Neck Necrosis|Post-Traumatic Femoral Neck Necrosis|Intact Femoral Neck With Good Bone Quality
Interventions: PROCEDURE: Total Hip Arthroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: DiEtary Sodium Intake Effects on Ertugliflozin-induced Changes in GFR, reNal Oxygenation and Systemic Hemodynamics: the DESIGN Study
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus|Diabetic Kidney Disease|Hypertension
Interventions: OTHER: Salt-Diet and/or Ertugliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Omega-3 Fatty Acid in Reducing Cancer-Related Fatigue in Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Carcinoma|Cancer|Fatigue
Interventions: DIETARY_SUPPLEMENT: Omega-3 Fatty Acid|OTHER: Placebo|OTHER: Questionnaire Administration|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Anti-PD-1/PD-L1 Antibodies Plus Pegylated Interferon Alfa-2b Treatment in Patients With Advanced-Stage HCC
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Anti-PD-1/PD-L1|DRUG: PEG-Interferon Alfa
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Evaluate the Safety, Tolerability and PK of GT20029 Gel and Solution in Healthy Subjects
Status: COMPLETED
Conditions: Acne|Alopecia
Interventions: DRUG: GT20029|DRUG: GT20029 matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Novel Pedicle Screws Used for Corrective Surgery in Spinal Deformity
Status: RECRUITING
Conditions: Spine Deformity
Interventions: PROCEDURE: double rods without dual-headed screw|PROCEDURE: three rods with one dual-headed screw|PROCEDURE: four rods with two dual-headed screw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Gamified Family-based Health Exercise Intervention to Improve Adherence to 24-h Movement Behaviors Recommendations in Children.
Status: ENROLLING_BY_INVITATION
Conditions: Physical Inactivity|Obesity, Childhood|Sedentary Behavior
Interventions: BEHAVIORAL: Gamified exercise training|BEHAVIORAL: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neurolinguistic Programming on Labor Pain
Status: RECRUITING
Conditions: Neurolinguistic Programming|Labor Pain
Interventions: OTHER: neuro linguistic programming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Novel Catheter Lock Solution for Treatment of Tunneled Hemodialysis Catheter-Associated Bacteremia
Status: COMPLETED
Conditions: End-Stage Renal Disease|Hemodialysis Catheter-associated Infection
Interventions: DRUG: catheter lock solution consisting of N-acetylcystein, tigecycline and heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Suprainguinal Fascia Iliaca Compartment Block in Direct Anterior Approach to Total Hip Arthroplasty
Status: WITHDRAWN
Conditions: Anesthesia, Local|Block
Interventions: PROCEDURE: Suprainguinal fascia ilica block|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial: Postoperative Opioid-free Analgesia
Status: COMPLETED
Conditions: Outpatient Surgery|Abdominal Surgery|Breast Surgery
Interventions: DRUG: Opioid analgesics|DRUG: Non-opioid analgesics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Sensory Deficits on Sensorimotor Control in Athletes With Chronic Ankle Instability
Status: RECRUITING
Conditions: Chronic Ankle Instability
Interventions: DEVICE: Transcutaneous electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Xeloda (Capecitabine) in Women With High-Risk Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: capecitabine [Xeloda]|DRUG: Taxotere|DRUG: Taxotere
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-cutoff Hemodialyzer to Reduce Chronic Inflammation in Hemodialysis Patients
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DEVICE: HCO1100 dialyzer|DEVICE: regular dialysis polyamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Fitbit® Quality of Measured Sleep to Sleep Measured by Polysomnography in the Sleep Lab
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Fitbit|OTHER: OSA questionnaire|DIAGNOSTIC_TEST: Polysomnography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Face-to-face Versus Online Hypnotherapy for the Treatment of Irritable Bowel Syndrome
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome
Interventions: OTHER: Face-to-face hypnotherapy|OTHER: Online hypnotherapy|OTHER: Online psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palliative Spatially Fractionated (GRID) Radiotherapy Using Intensity Modulated Proton Therapy
Status: RECRUITING
Conditions: Unresectable Solid Tumor|Metastatic Cancer
Interventions: RADIATION: Proton GRID Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Near-Assisted Learning (NAL) in Improving Students' Objective Structured Clinical Examination (OSCE) Grades
Status: COMPLETED
Conditions: Cost|Problem-based Learning|Peer Group
Interventions: BEHAVIORAL: Near-assisted learning through trained peers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Testing a Promising Treatment for Youth Substance Abuse in a Community Setting
Status: COMPLETED
Conditions: Substance Abuse|Delinquency|Mental Health
Interventions: BEHAVIORAL: Contingency Management-Family Engagement|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Prevalence of Psychiatric Manifestations in Purely Obstetrical Antiphospholipid Syndrome
Status: TERMINATED
Conditions: Antiphospholipid Syndrome
Interventions: BIOLOGICAL: Antiphospholipid antibody tests|BIOLOGICAL: Thrombophilia bloodwork|OTHER: Psychiatric evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Biphasic Insulin Aspart 70/30 With Anti-Diabetic Drugs in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart|DRUG: pioglitazone|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Unexpected Positive Cultures in Rotator Cuff Revision Surgery
Status: RECRUITING
Conditions: Rotator Cuff Repair
Interventions: OTHER: This study is with minimal risk and minimal constraints due to the addition of questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: 12 Month Extension Study of the Effect of Teriparatide on Bone in People With Chronic Spinal Cord Injury (SCI)
Status: COMPLETED
Conditions: Spinal Cord Injury|Bone Loss|Osteoporosis
Interventions: DRUG: Teriparatide|DEVICE: Vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Guaifenesin and Pseudoephedrine for Symptomatic Therapy to Treat Acute RTI
Status: COMPLETED
Conditions: Acute Upper Respiratory Track Infection
Interventions: DRUG: Guaifenesin|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Biomarker Study of EPI-589 in Participants With Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: EPI-589
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of IVX-A12 in Adults Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Participants
Interventions: BIOLOGICAL: IVX-A12|BIOLOGICAL: Licensed RSV Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of the Combination of Acalabrutinib (ACP-196) and Pembrolizumab in Advanced Head and Neck Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: pembrolizumab|DRUG: Acalabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Kinesiology Taping Application on Severity of Signs and Symptoms in Breast Engorgement.
Status: UNKNOWN
Conditions: Lactation Disorders
Interventions: OTHER: Kinesiology taping application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Relationship Between the Risk of Falls and Frailty, and the Effect of a Physical Exercise Program on These Conditions in the Elderly: a Randomized Crossover Clinical Trial.
Status: RECRUITING
Conditions: Frail Elderly Syndrome|Fall
Interventions: OTHER: Therapeutic exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ipilimumab and Nivolumab in Patients With Anti-PD-1-axis Therapy-resistant Advanced Non-small Cell Lung Cancer.
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: BIOLOGICAL: combination nivolumab and ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GORE PROPATEN Vascular Graft vs. Disadvantaged Autologous Vein Graft
Status: TERMINATED
Conditions: Peripheral Arterial Occlusive Disease
Interventions: DEVICE: GORE PROPATEN Vascular Graft|PROCEDURE: Disadvantaged Autologous Vein Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Fixed Mandibular Retainer Using 3D Printed Positioning Tray Versus Direct Bonding Technique
Status: COMPLETED
Conditions: Orthodontic Appliance Complication
Interventions: DEVICE: 3d printed positioning tray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effectiveness of a CBT-based mHealth Intervention Targeting MOUD Retention, Adherence, and Opioid Use
Status: ENROLLING_BY_INVITATION
Conditions: Opioid-use Disorder
Interventions: BEHAVIORAL: imFREE mCBT|BEHAVIORAL: mHealth ED
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IRS(Irradiation Stent) vs. CS(Conventional Stent) Insertion in Inoperable Malignant Biliary Obstruction
Status: COMPLETED
Conditions: Malignant Biliary Obstruction
Interventions: DEVICE: Biliary SEMS loaded with 125I seeds|DEVICE: Conventional biliary SEMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venetoclax With Ibrutinib or Acalabrutinib in Pts. With High-risk CLL
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Ibrutinib|DRUG: Venetoclax|DRUG: Acalabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Corticosteroid Infusion in Vasoplegia After Cardiac Surgery (CORTIVAS-CS)
Status: UNKNOWN
Conditions: Vasoplegia|Cardiac Surgery
Interventions: DRUG: hydrocortisone sodium succinate|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study of Cetirizine HCl 10 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cetirizine Hydrochloride 10 mg tablets, single dose|DRUG: Zyrtec® 10 mg tablets, single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: The Effects of Intratesticular PRP Injection in Men With Azoospermia or Cryptozoospermia
Status: COMPLETED
Conditions: Azoospermia, Nonobstructive
Interventions: BIOLOGICAL: PRP injection into at least one testis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study Focuses on Training Newly Employed Nurses With Two Groups Interventional (Simulation Training) & Control (Brochure) Group Using BLS -AHA 2020 Using Simulation, the Test Includes Pre-test & 2 Post-test Surveys to Assess Knowledge, Practice & Confidence Level.
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Nurses|Educational Activities
Interventions: OTHER: Simulation in basic life support training (SBLST)|OTHER: standard treatment by using an AHA-BLS 2020 brochure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Shoulder Instability Trial Comparing Arthroscopic Stabilization Benefits Compared With Latarjet Procedure Evaluation - STABLE Definitive Trial
Status: RECRUITING
Conditions: Shoulder Dislocation|Sport Injuries|Anterior Dislocation
Interventions: PROCEDURE: Bankart + Remplissage Procedure|PROCEDURE: Latarjet Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pediatric Trial of Genetically Modified Autologous T Cells Directed Against CD19 for Relapsed CD19+ Acute Lymphoblastic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: B Cell Leukemia
Interventions: BIOLOGICAL: Autologous CD19 CAR+ EGFTt + T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parallel Group, Multiple Dose Pharmacokinetics Study of Five Antipsychotic Medications in Psychiatric Participants
Status: COMPLETED
Conditions: Psychotic Disorders|Schizophrenia|Bipolar Disorder|Depressive Disorder
Interventions: DRUG: Aripiprazole, oral formulation|DRUG: Olanzapine, oral formulation|DRUG: Paliperidone, oral formulation|DRUG: Paliperidone, LAI|DRUG: Quetiapine, oral formulation|DRUG: Risperidone, oral formulation|DRUG: Risperidone, LAI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Search for Structural Variants in Patients With DSD and Inconclusive Molecular Diagnosis
Status: RECRUITING
Conditions: Disorder of Sex Development, 46,XY
Interventions: DIAGNOSTIC_TEST: Identify structural variants by Optical Genome Mapping of DNA extracted from blood leukocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety Study of a Disrupted Adenovirus (Ad) Serotype Cocaine Vaccine for Cocaine-dependent Individuals
Status: RECRUITING
Conditions: Cocaine Dependence
Interventions: BIOLOGICAL: dAd5GNE Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carboplatin and Topotecan in Treating Patients With Relapsed or Metastatic Cervical Cancer
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: DRUG: carboplatin|DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of an Intervention Involving Cognitive Training and tDCS in Morbidly Obese Subjects
Status: COMPLETED
Conditions: Obesity, Morbid|Obesity (BMI > 35) and Diabetes Mellitus|Obesity (BMI > 35) and High Blood Pressure|Obesity (BMI > 35) and Dyslipemia
Interventions: OTHER: Cognitive Training|DEVICE: transcranial Direct-Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Dose PET/CT-guided Intensity Modulated Radiotherapy and Concurrent Chemotherapy in Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: RADIATION: high dose radiation therapy with concurrent chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability and Pharmacokinetics of PF-04958242 in Healthy Adult Volunteers
Status: TERMINATED
Conditions: Healthy Volunteers
Interventions: DRUG: PF-04958242|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Bridging Study of FB2001 in Healthy Subjects
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: FB2001|OTHER: FB2001 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Dose Study in Participants With LCA10
Status: ACTIVE_NOT_RECRUITING
Conditions: Leber Congenital Amaurosis 10|Inherited Retinal Dystrophies|Eye Diseases, Hereditary|Retinal Disease|Retinal Degeneration|Vision Disorders|Eye Disorders Congenital
Interventions: DRUG: EDIT-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preemptive Pharmacogenomics Testing Among Geriatric Patients
Status: ENROLLING_BY_INVITATION
Conditions: Polypharmacy|Pharmacogenomic Testing
Interventions: GENETIC: Multigene pharmacogenomics test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Randomised Trial of Telehealth Consultations for Nursing Care of Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: COMPLETED
Conditions: COPD
Interventions: BEHAVIORAL: Telehealth consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Women With Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: docetaxel|DRUG: doxorubicin hydrochloride|DRUG: tamoxifen citrate|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Vactosertib in Combination With Pembrolizumab for PD-L1 Positive Non-small Cell Lung Cancer (NSCLC) Subjects
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Vactosertib 300 mg BID and pembrolizumab 200 mg IV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Diosmin and Hesperidin in Treatment of Patients With Rheumatoid Arthritis
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Diosmin and Hesperidin Combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine Whether the Instillation of 10ml Normal Saline Improves Epidural Analgesia During Labor
Status: WITHDRAWN
Conditions: Parturients
Interventions: OTHER: Normal Saline|PROCEDURE: Administration of epidural anesthesia for labor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Plerixafor Plus Granulocyte Colony-stimulating Factor (G-CSF) For Mobilization And Collection Of Peripheral Hematopoietic Stem Cells In Japanese Participants With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: plerixafor GZ316455|DRUG: Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Pharmacodynamic Parameter and Tolerability With Subcutaneous Immunotherapy in Grass Pollen Allergic Patients
Status: COMPLETED
Conditions: Rhinitis|Conjunctivitis|Asthma
Interventions: BIOLOGICAL: subcutaneous immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Metformin in Overweight Patients With Dysregulated Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Tablet Metformin 500 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Toripalimab Maintenance for Locally Advanced Head and Neck Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Grip&Health: Behavioural Intervention to Reduce Smoking, Stress and Improve Financial Health in Low-SES in Rotterdam
Status: UNKNOWN
Conditions: Smoking Cessation|Smoking, Cigarette|Smoking|Stress|Stress, Psychological|Health Behavior|Smoking, Tobacco
Interventions: BEHAVIORAL: Stress management program (SM)|BEHAVIORAL: Stress management + Buddy program (SM-B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: THE EFFECT OF VIRTUAL REALITY APPLICATION ON PAIN, ANXIETY, AND COMFORT DURING CURETTAGE/DILATATION
Status: ENROLLING_BY_INVITATION
Conditions: Bleeding;Post D&C|PAIN, ANXIETY, AND COMFORT
Interventions: DEVICE: virtula reality goggles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Is Regression Possible in Lumbal Disc Herniation With Spinal Mobilization Applications?
Status: COMPLETED
Conditions: Intervertebral Disc Displacement|Disk Herniated Lumbar|Disc Herniation
Interventions: BEHAVIORAL: Spinal Mobilization|BEHAVIORAL: Stabilization Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Nosocomial Infections in Critically Ill Patients With Lactoferrin: The PREVAIL Study
Status: COMPLETED
Conditions: Critically Ill
Interventions: DIETARY_SUPPLEMENT: Lactoferrin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Alcohol and Mood on Attention
Status: COMPLETED
Conditions: Suicidal Ideas
Interventions: OTHER: Alcohol administration|OTHER: Placebo administration|BEHAVIORAL: Positive mood induction|BEHAVIORAL: Negative mood induction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Aripiprazole in the Treatment of Acutely Relapsed Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Aripiprazole|DRUG: Risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of BlephEx to MiBoflo as Treatment Options for Blepharitis
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction|Dry Eye|Posterior Blepharitis
Interventions: DEVICE: Blephex|DEVICE: MiboFlo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: (Ro 24-2027) A Randomized, Double-Blind, Comparative Study of Dideoxycytidine (ddC) Versus Zidovudine (AZT) in Patients With AIDS or Advanced ARC
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zidovudine|DRUG: Zalcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: OMEGA - Dietary Intervention - COPD Trial
Status: RECRUITING
Conditions: COPD, Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: Home delivery Omega-3 rich Food|BEHAVIORAL: Dietary Motivational Coaching|BEHAVIORAL: Home delivery Food
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Assessment of Seminal Levels of Cystatin C and Endoglin in Infertile Men With Varicocele
Status: COMPLETED
Conditions: Varicocele|Infertility, Male
Interventions: PROCEDURE: Varicocelectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE