pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study to Assess the Efficacy and Safety of STI-1558 in Adult Subjects With Mild or Moderate (COVID-19)
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: STI-1558|DRUG: STI-1558 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Bevacizumab and Chemotherapy or Tarceva in Treating Recurrent or Refractory NSCLC (Non-Small Cell Lung Cancer)
Status: COMPLETED
Conditions: Non-Small-Cell Lung Carcinoma|Neoplasm Recurrence, Local
Interventions: DRUG: Avastin (bevacizumab)|DRUG: Tarceva (erlotinib HCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study to Understand How the Study Medicine Called ARV-471 is Processed in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: [phenyl-14C]ARV-471|DRUG: [oxoisoindolin-14C]ARV-471
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Levosimendan in High Risk Patients Undergoing Cardiac Surgery
Status: COMPLETED
Conditions: Low Cardiac Output Syndrome
Interventions: DRUG: Levosimendan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Communicating Evidence From Systematic Reviews to the Public
Status: COMPLETED
Conditions: Adult
Interventions: OTHER: New plain language summary format|OTHER: Current plain language summary format
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Study To Establish The Equivalence Of 2 Palbociclib (PD-0332991) Formulations To The Intended Final Market Product
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: palbociclib capsule: phase 1 and 2 studies|DRUG: Palbociclib capsule: phase 3 studies|DRUG: Palbociclib capsule: ICH
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Prebiotics on Gastrointestinal Functioning and Metabolism
Status: COMPLETED
Conditions: Change of Transit or Circulation|Obesity
Interventions: DIETARY_SUPPLEMENT: soluble wheat bran fibre|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Absorption of Vaginal Diazepam Using Different Delivery Systems
Status: TERMINATED
Conditions: Metabolism, Drug
Interventions: DRUG: Diazepam tablet, 5 mg, vaginal|DRUG: Diazepam Suppository, 5 mg, vaginal|DRUG: Diazepam Cream, 5 mg, Vaginal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: VTX958 Versus Placebo for the Treatment of Active Psoriatic Arthritis (Tranquility-PsA)
Status: TERMINATED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Dose A VTX958|DRUG: Dose B VTX958|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing a Patient Self-Assessment Software to Treatment as Usual in Opioid Prescriber and Patient Opioid Outcomes
Status: UNKNOWN
Conditions: Opioid-use Disorder|Opioid Misuse|Opioid Use|Chronic Pain
Interventions: OTHER: Care Continuity Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Physiologic Study of Cerebral Perfusion
Status: COMPLETED
Conditions: Cerebral Perfusion Pressure|Vasopressor Agents|Shock|Magnetic Resonance Imaging (MRI), Functional
Interventions: DRUG: Higher doses of vasopressor therapy for a MAP of 75 mmHg|DRUG: Lower doses of vasopressor therapy for a MAP of 65 mmHg|DRUG: Propofol for light sedation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cardiac MRI Prior to Invasive Coronary Angiography in Patients With Suspected Non-ST-Elevation Myocardial Infarction
Status: RECRUITING
Conditions: Non-ST Elevation Myocardial Infarction|Acute Coronary Syndrome
Interventions: DIAGNOSTIC_TEST: Cardiac MRI (CMR) examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Preliminary Study About Unexplained Recurrent Miscarriage and Repeated Implantation Failure Patients Treated With Low-dose Lymphocyte Immunotherapy
Status: COMPLETED
Conditions: Unexplained Recurrent Miscarriage and Recurrent Implantation Failure
Interventions: PROCEDURE: low-dose lymphocyte immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating The Safety Of Donepezil Hydrochloride (Aricept) For Up To 1 Year In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome - Follow-Up To A 10-Week, Double-Blind, Placebo-Controlled Trial
Status: TERMINATED
Conditions: Down Syndrome
Interventions: DRUG: Donepezil hydrochloride (Aricept)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fascia Iliaca Versus Quadratus Lumborum Block for Pain Management in Total Hip Replacement.
Status: COMPLETED
Conditions: Postoperative Opioid Requirements in Patients With Traumatic Fracture Hip
Interventions: PROCEDURE: Fascia Iliaca block|PROCEDURE: Quadratus lumborum block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phosphatidylcholine (LT-02) for Induction of Remission in Ulcerative Colitis
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: DRUG: LT-02|DRUG: LT-02|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility, Validation and Application of Digital Tools for the Follow-up of Neuromuscular Patient Mobility in Daily Living
Status: RECRUITING
Conditions: Neuromuscular Diseases
Interventions: OTHER: 2MWT|OTHER: MFM32|OTHER: MyoGrip|OTHER: QOL-gNMD|DIAGNOSTIC_TEST: Spirometry|DEVICE: Acceleromerty|OTHER: 10mWT|OTHER: PUL|OTHER: NSAA|OTHER: NSAD|OTHER: TANS|OTHER: MyoPinch|OTHER: MyoQuad|OTHER: ACTIVLIM|OTHER: PREM|OTHER: SF-MPQ|OTHER: FSS|OTHER: IPAQ|OTHER: Rang of motion|DEVICE: Goniometry|OTHER: Video captured monitoring|DEVICE: Activity monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Teleguidance-facilitated Airway Management
Status: COMPLETED
Conditions: Telemedicine|Intubation; Difficult or Failed|Emergencies
Interventions: DEVICE: Teleguidance-facilitated Airway Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Colchicine and Spironolactone in Patients With MI / SYNERGY Stent Registry
Status: ACTIVE_NOT_RECRUITING
Conditions: ST Elevation Myocardial Infarction|Non ST Elevation Myocardial Infarction
Interventions: DRUG: Colchicine|DRUG: Spironolactone|DEVICE: SYNERGY Bioabsorbable Polymer Drug-Eluting Stent|DRUG: Colchicine-Placebo|DRUG: Spironolactone-Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of Allo GDA-201 NK Cells in Patients With Relapsed/Refractory B Cell NHL
Status: TERMINATED
Conditions: Non-Hodgkin Lymphoma
Interventions: DRUG: GDA-201
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Doxorubicin and Trastuzumab in Treating Women With Locally Advanced, Inflammatory, or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: trastuzumab|DRUG: pegylated liposomal doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Concurrent Chemoradiation With or Without DC-CIK Immunotherapy in Treating Locally Advanced Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Carcinoma
Interventions: OTHER: concurrent chemoradiotherapy plus DC-CIK immunotherapy|OTHER: Concurrent chemoradiation only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of BAY1192631 in Japanese Patients With Methicillin-resistant Staphylococcus Aureus (MRSA) Infections
Status: COMPLETED
Conditions: Skin Diseases, Infectious
Interventions: DRUG: Tedizolid Phosphate (Sivextro, BAY1192631)|DRUG: Linezolid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Of Hot Flashes/Flushes In Postmenopausal Women (WARM Study)
Status: COMPLETED
Conditions: Menopausal and Female Climacteric States
Interventions: DRUG: Other: Placebo|DRUG: GSK232802|DRUG: PREMARIN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Diabetic and Idiopathic Gastroparesis Efficacy, Safety, and Tolerability (DIGEST) Study
Status: COMPLETED
Conditions: Gastroparesis
Interventions: DRUG: Velusetrag|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ICG Angiography in Amniotic Membrane Graft and Conjunctival Autograft After Pterygium Excision
Status: COMPLETED
Conditions: Pterygium
Interventions: PROCEDURE: Anterior segment indocyanine green angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: SCREENING
Clinical trial: Relationship of Periodontal Disease Treatment and Type 2 Diabetes Mellitus in the Gullah Population
Status: COMPLETED
Conditions: Periodontal Disease|Type 2 Diabetes Mellitus
Interventions: DRUG: Placebo|DRUG: Doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Locally Made Titanium Miniplate and Screw in Maxillofacial Fractures Management
Status: TERMINATED
Conditions: Maxillofacial Injuries|Maxillofacial Prosthesis Implantation|Fracture Fixation, Internal
Interventions: DEVICE: ORIF (Open reduction internal fixation): locally-made miniplate and screw|DEVICE: ORIF: Imported miniplate and screw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Trial of Nivolumab in Combination With HF10 Oncolytic Viral Therapy in Resectable Stage IIIB, IIIC, IVM1a Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: Nivolumab|DRUG: HF10
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multidisciplinary Digital Therapeutics of Chronic Lower Back Pain Versus Usual Care
Status: COMPLETED
Conditions: Chronic Low-back Pain
Interventions: DEVICE: MORT-LBP|OTHER: treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Supported Employment Versus Standard Vocational Rehabilitation in Veterans With Post-traumatic Stress Disorder
Status: UNKNOWN
Conditions: PTSD
Interventions: BEHAVIORAL: Supported Employment (SE)|BEHAVIORAL: Standard Vocational Rehabilitation (VRP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Multi-Center Trial of High-resolution Transrectal Ultrasound Versus Standard Low-resolution Transrectal Ultrasound for the Identification of Clinically Significant Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasms|Prostate Cancer|Cancer of the Prostate
Interventions: DEVICE: High-resolution ultrasound guided prostate biopsy|DEVICE: Standard ultrasound guided prostate biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Icotinib Hydrochloride in Treating Patients With Recurrent or Metastatic Esophageal Cancer After Failure of Conventional Chemotherapy
Status: COMPLETED
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Icotinib Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: On-pump Intraoperative Echocardiography
Status: COMPLETED
Conditions: Septal Myectomy
Interventions: DEVICE: Pre Operative On-pump intraoperative echocardiography|DEVICE: Pre Operative Transesophageal echocardiography (TEE) imaging|DEVICE: Post Operative On-pump intraoperative echocardiography|DEVICE: Post Operative Transesophageal echocardiography (TEE) imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Lean Pork, High Protein Breakfast on Satiety and Metabolic Health in Pre-diabetes
Status: COMPLETED
Conditions: Pre-diabetes
Interventions: OTHER: Refined carbohydrate-rich breakfast|OTHER: High pork protein breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluating Buprenorphine/Naloxone Microdosing vs. Standard Dosing in Emergency Departments
Status: RECRUITING
Conditions: Opioid-use Disorder
Interventions: DRUG: Buprenorphine/naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Bacterial Lysate on Nasal Carriage of Staphylococcus Aureus
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Ismigen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: REmimazolam Infusion in the Context of Hypnotic Shortage in the Critical Care Unit During the Pandemic of COVID-19: REHSCU Study
Status: COMPLETED
Conditions: Acute Respiratory Failure|COVID-19|Trauma|Stroke|Sepsis|Shock
Interventions: DRUG: Remimazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Metabolic Phenotyping During Stress Hyperglycemia in Cardiac Surgery Patients
Status: TERMINATED
Conditions: Stress Hyperglycemia
Interventions: DRUG: Dulaglutide Injection|OTHER: Saline Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Nilotinib in Ph+ CML-CP Patients With Low Imatinib Trough Plasma Concentrations
Status: TERMINATED
Conditions: CML|Philadelphia Chromosome Positive (Ph+)|Chronic Myelogenous Leukemia Chronic Phase(CML-CP) Patients With Low Imatinib Trough Levels
Interventions: DRUG: nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intratracheal Umbilical Cord-derived Mesenchymal Stem Cell for the Treatment of Bronchopulmonary Dysplasia (BPD)
Status: WITHDRAWN
Conditions: Bronchopulmonary Dysplasia
Interventions: DRUG: Human Umbilical Cord-derived Mesenchymal stem cell|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short Term Outcomes Of Tricuspid Valve Annuloplasty Using A Flexible Band
Status: NOT_YET_RECRUITING
Conditions: Valvular Heart Disease|Tricuspid Valve Regurgitation
Interventions: OTHER: Annuloplasty Using Flexible Band
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maternal Telemental Health Interventions in Response to Covid-19*
Status: TERMINATED
Conditions: Perinatal Depression|Specific Phobia|Perinatal Anxiety
Interventions: OTHER: Low-Intensity Psychosocial Interventions through Telemental health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optimized tDCS for Fibromyalgia: Targeting the Endogenous Pain Control System
Status: RECRUITING
Conditions: Fibromyalgia
Interventions: DEVICE: Active tDCS|PROCEDURE: Active Exercise|DEVICE: Sham tDCS|PROCEDURE: Sham Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Topical Tacrolimus in Vernal Keratoconjunctivitis
Status: UNKNOWN
Conditions: Vernal Keratoconjunctivitis
Interventions: DRUG: Topical tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Value of Heart Rate Variability Indexes to Predict Outcomes After Exercise Training in Chronic Heart Failure
Status: COMPLETED
Conditions: Heart Failure|Systolic Heart Failure
Interventions: BEHAVIORAL: Cardiac Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-blind, Controlled Study to Evaluate the Effect of Concord Grape Extract on Vascular Function in Healthy Men and Women
Status: COMPLETED
Conditions: Healthy Men and Women
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Concord Grape extract 1|DIETARY_SUPPLEMENT: Concord Grape extract 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Pythagorean Self-Awareness for Aging Biomarkers Improvement, in T2D Patients and Healthy Individuals.
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Telomere Shortening
Interventions: BEHAVIORAL: Pythagorean Self-Awareness Intervention(PSAI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction Study Between GSK1349572 and Tipranavir/Ritonavir in Healthy Volunteers
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus|HIV Infections
Interventions: DRUG: GSK1349572
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study To Evaluate The Safety Of CMTX-101 In People With Cystic Fibrosis
Status: RECRUITING
Conditions: Persistent Infection|Cystic Fibrosis
Interventions: DRUG: CMTX-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PFC Sigma Fixed and Mobile Knee Study
Status: TERMINATED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: P.F.C Sigma Fixed Bearing total knee system|DEVICE: P.F.C Sigma RP Mobile Bearing knee system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Prothione™ Capsules for Mild to Moderate Coronavirus Disease 2019 (COVID-19)
Status: COMPLETED
Conditions: Coronavirus Disease 2019 (COVID-19)
Interventions: DRUG: Placebo|DRUG: Prothione™ (6g)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Blinded User Study for the Evaluation of the Acceptability and Efficacy of One Medical Device in Venous Return in Comparison With a Control Group
Status: COMPLETED
Conditions: Venous Disease|Quality of Life|Symptoms and Signs
Interventions: DEVICE: Insoles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Tiotropium (18mcg) in Chronic Obstructive Pulmonary Disease (COPD) Patients With a Respiratory Infection
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: tiotropium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Periodontal Surgery in Supra-alveolar-type Defects With or Without Straumann® Emdogain
Status: TERMINATED
Conditions: Periodontal Attachment Loss|Periodontal Diseases
Interventions: DEVICE: Emdogain|PROCEDURE: Periodontal surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Nutritional Interventions on Exercise-induced Muscle Damage
Status: COMPLETED
Conditions: Muscle Damage
Interventions: DIETARY_SUPPLEMENT: Omega 3|DIETARY_SUPPLEMENT: Isolate whey protein|DIETARY_SUPPLEMENT: Omega 3 and Isolate whey protein|OTHER: Eccentric exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase I, Randomized, Double-Blind, Placebo-Controlled Safety, Tolerability and Immunogenicity Study of Candidate HIV-1 Vaccines ChAdOx1.HTI and MVA.HTI With Recombinant HIV-1 Envelope Protein ConM SOSIP.v7 gp140 Vaccine, Adjuvanted With MPLA Liposomes in ART-Suppressed HIV-1 Positive Individuals
Status: COMPLETED
Conditions: HIV Infection
Interventions: BIOLOGICAL: ChAdOx1.HTI at week 0, ConM SOSIP.v7 at weeks 4, 12 and 28, and MVA.HTI at week 22 (CSSMS).|OTHER: Normal saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Resveratrol's Effects on Inflammation and Oxidative Stress in Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Renal Insufficiency
Interventions: DIETARY_SUPPLEMENT: Resveratrol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Of Deoxycoformycin(DCF)/Pentostatin In Lymphoid Malignancies
Status: COMPLETED
Conditions: Peripheral T-cell Lymphoma|Cutaneous T-cell Lymphoma|Chronic Lymphocytic Leukemia
Interventions: DRUG: Deoxycoformycin (DCF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of metfOrmin in PrevenTIng Glucocorticoid-induced Diabetes in Patients With Brain Metastases
Status: UNKNOWN
Conditions: Brain Metastases|Melanoma|Lung Cancer|Breast Cancer
Interventions: DRUG: Dexamethasone|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Multiple-dose Study of Gantenerumab in Japanese Alzheimer&Apos;s Disease Patients
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Gantenerumab|DRUG: Gantenerumab|DRUG: Gantenerumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Synergistic Pharmacologic Intervention for Prevention of ROP (SPIPROP Study)
Status: COMPLETED
Conditions: Retinopathy of Prematurity
Interventions: DRUG: Caffeine citrate|DRUG: Ibuprofen|DRUG: Ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Correcting Circadian Rhythms to Breakthrough in Bipolar Disorder
Status: ENROLLING_BY_INVITATION
Conditions: Bipolar Disorder|Delayed Sleep-Wake Phase Disorder
Interventions: DRUG: Melatonin|OTHER: Placebo|BEHAVIORAL: Behavioral sleep intervention|BEHAVIORAL: Behavioral sleep control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Rituximab in Patients With Steroid-Refractory Chronic Graft-Versus-Host Disease
Status: UNKNOWN
Conditions: Steroid-Refractory Chronic GVHD
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Working Memory Training in Adults With ADHD
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: Flex working memory training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of TTI-622 in Combination With Daratumumab Hyaluronidase-fihj in People With Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: TTI-622|DRUG: Daratumumab Hyaluronidase-fihj
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Truncated and Extended Forms of Amyloid Beta Peptides in Alzheimer's Disease: Genesis, Toxicity and Identification as Biological Markers
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: OTHER: Alzhamyd
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Assessing Colonisation & Immunogenicity After Nasal Inoculation With N. Lactamica and Eradication on Day 4 or 14
Status: UNKNOWN
Conditions: Meningitis, Meningococcal
Interventions: BIOLOGICAL: Neisseria lactamica
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Stimulation Patterns of Deep Brain Stimulation
Status: ENROLLING_BY_INVITATION
Conditions: Parkinson Disease|Essential Tremor|Multiple Sclerosis|Dystonia
Interventions: PROCEDURE: Therapeutic Stimulation Patterns|PROCEDURE: Symptogenic Stimulation Patterns
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect Study of Parecoxib to Treat Emergence Delirium and Postoperative Pain
Status: UNKNOWN
Conditions: Emergence Delirium|Postoperative Pain
Interventions: DRUG: Parecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Evaluation of the ELAD System in the Management of Acute Liver Failure
Status: COMPLETED
Conditions: Fulminant Hepatic Failure
Interventions: BIOLOGICAL: ELAD|OTHER: Standard of care (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.
Status: NOT_YET_RECRUITING
Conditions: Graft Vs Host Disease|Vitamin A Deficiency|Vitamin D Deficiency
Interventions: DRUG: Vitamin A|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fibroscan® Medical Device, Assessment for Non Invasive Diagnosis of Liver Steatosis
Status: UNKNOWN
Conditions: Liver Steatosis
Interventions: DEVICE: Fibroscan|BIOLOGICAL: Blood test for biological assessment of liver function|DEVICE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Single-arm, Open-label, Single-center Prospective Study of Fruquintinib Combined With Envafolimab in the Treatment of Advanced or Unresectable Locally Advanced Bone and Soft Tissue Sarcoma
Status: RECRUITING
Conditions: Advanced or Unresectable Locally Advanced Bone and Soft Tissue Sarcoma
Interventions: DRUG: fruquintinib|DRUG: Envafolimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enoblituzumab Plus Retifanlimab or Tebotelimab in Head and Neck Cancer
Status: TERMINATED
Conditions: Head and Neck Cancer|Head and Neck Neoplasms|Head and Neck Squamous Cell Carcinoma
Interventions: BIOLOGICAL: Enoblituzumab|BIOLOGICAL: Retifanlimab|BIOLOGICAL: Tebotelimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeting Circadian and Cognitive Dysfunction in Bipolar Disorder With Modafinil
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Modafinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Twelve-week, Double-blind, Placebo-controlled, Randomized, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Solriamfetol in the Treatment of Excessive Daytime Sleepiness (EDS) in Patients With Obstructive Sleep Apnea (OSA)
Status: RECRUITING
Conditions: Excessive Daytime Sleepiness Associated With Obstructive Sleep Apnea
Interventions: DRUG: Solriamfetol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study of Gefapixant (AF-219/MK-7264) in Refractory Chronic Cough (MK-7264-010)
Status: COMPLETED
Conditions: Refractory Chronic Cough
Interventions: DRUG: Gefapixant|DRUG: Placebo (for gefapixant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Donor Human Milk and Neurodevelopmental Outcomes in Very Low Birthweight (VLBW) Infants
Status: COMPLETED
Conditions: Neurodevelopmental Outcomes of VLBW Infants
Interventions: DIETARY_SUPPLEMENT: Donor Human Milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Hypo-osmolar Drops on Contact Lens Comfort
Status: COMPLETED
Conditions: Contact Lens Related Dry Eye
Interventions: DEVICE: Hypo-osmolar drop 1|DEVICE: Hypo-osmolar drop 2|DEVICE: Iso-osmolar drop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: iCardia4HF: Multi-component mHealth Intervention for Patients With Heart Failure
Status: NOT_YET_RECRUITING
Conditions: Heart Failure
Interventions: BEHAVIORAL: Text4HF|BEHAVIORAL: MyApps|BEHAVIORAL: MyApps & Text4HF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of a Novel Radiopaque Embolic Agent in Prostatic Artery Embolisation for Symptomatic Benign Prostatic Enlargement
Status: UNKNOWN
Conditions: Benign Prostatic Hyperplasia
Interventions: DEVICE: DC Lumi Bead, BTG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Lifestyle Intervention for Type 2 Diabetes Patients in Kuwait and Its Impact on Glycaemic Control
Status: COMPLETED
Conditions: Diabetes Mellitus, Noninsulin-Dependent|Diabetes, Type 2
Interventions: BEHAVIORAL: Lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clareon Toric vs Eyhance Toric
Status: COMPLETED
Conditions: Cataract|Aphakia
Interventions: DEVICE: Clareon IOL|DEVICE: Clareon Toric IOL|DEVICE: Eyhance IOL|DEVICE: Eyhance Toric IOL|PROCEDURE: Phacoemulsification surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ICBT for OCD in Children With Autism
Status: NOT_YET_RECRUITING
Conditions: Obsessive-Compulsive Disorder|Autism Spectrum Disorder
Interventions: BEHAVIORAL: Internet-delivered exposure and response prevention (I-ERP)|BEHAVIORAL: Internet-delivered stress management (I-SM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Filter During CPET on WOB and Aerosol Particle Concentrations
Status: TERMINATED
Conditions: Transmission, Patient-Professional
Interventions: DEVICE: Respiratory filter in-line placed with the standard mouthpiece|OTHER: Standard mouthpiece
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Saxagliptin, 5-Hydroxy Saxagliptin, and Metformin Concentrations/Levels in Pediatric Subjects With T2DM
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Metformin immediate release (IR)|DRUG: Saxagliptin|DRUG: Metformin IR|DRUG: Saxagliptin/Metformin XR FDC|DRUG: Metformin XR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Irritation and Sensitization of Chlorhexidine Gluconate (CHG) Cloth
Status: COMPLETED
Conditions: Surgery
Interventions: DRUG: 2% CHG Cloth solution|DEVICE: Vehicle Cloth|DRUG: Active Comparator|OTHER: Saline|OTHER: SLS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: At-home Transcranial Alternating Current Stimulation During Multitasking
Status: COMPLETED
Conditions: Multitasking Behavior
Interventions: DEVICE: Transcranial alternating current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Supplementation of YMETA, on Gut Health, Immunity and Metabolism in Pre-diabetic Adult Population
Status: COMPLETED
Conditions: Pre-diabetes
Interventions: DIETARY_SUPPLEMENT: YMETA|OTHER: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Sevoflurane and Remimazolam on Arterial Oxygenation During One-lung Ventilation
Status: COMPLETED
Conditions: One-Lung Ventilation|Thoracic Surgery, Video-Assisted|Remimazolam
Interventions: DRUG: Remimazolam|DRUG: 1% propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Dose Dense Paclitaxel With Pembrolizumab (MK-3475) in Platinum Resistant Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Protandim Supplementation on Oxidative Damage and Athletic Performance
Status: COMPLETED
Conditions: Oxidative Stress
Interventions: DIETARY_SUPPLEMENT: Protandim Dietary Supplement|OTHER: Placebo Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of SM101 in the Treatment of IgA Nephropathy
Status: WITHDRAWN
Conditions: Immunoglobulin A Nephropathy
Interventions: BIOLOGICAL: SM101|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety/Tolerability Profile of CKD-379
Status: COMPLETED
Conditions: Type II Diabetes Mellitus
Interventions: DRUG: CKD-379 I|DRUG: CKD-379 II|DRUG: D759+D745+D150
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction Study of Isavuconazole and Warfarin in Healthy Male Subjects
Status: COMPLETED
Conditions: Pharmacokinetics of Isavuconazole|Pharmacokinetics of S- and R-warfarin|Pharmacodynamics of Warfarin|Healthy Volunteers
Interventions: DRUG: Isavuconazole|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Nasal Swab studyComparison of Effectiveness of Povidone-iodine Versus Saline Versus 3M Skin and Nasal Antiseptic 5% Povidone-Iodine USP Swabs for Decolonizing Intranasal MSSA/MRSA
Status: UNKNOWN
Conditions: MRSA/ MSSA Colonization of the Nares
Interventions: DRUG: Saline|DRUG: Povidone-Iodine|DRUG: 5% Povidone-Iodine USP swabs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Immunocompromised Swiss Cohorts Based Trial Platform
Status: COMPLETED
Conditions: Immunocompromised Patients
Interventions: BIOLOGICAL: Moderna COVID-19 Vaccine, mRNA-1273 (100 μg)|BIOLOGICAL: Pfizer-BioNTech COVID-19 Vaccine BNT162b2 (30 µg)( Comirnaty®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Erector Spinae Plane Block Versus Oblique Subcostal Transverses Abdominis Plane Block
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: PROCEDURE: erector spinae plane (ESP) block|PROCEDURE: oblique subcostal transverse abdominis plane (TAP) block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Photodynamic Therapy (PDT) With Methyl Aminolevulinate (MAL) Cream in Moderate to Severe Acne
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Methyl aminolevulinate (MAL) PDT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GnRH-a and Pregnancy Rate in In Vitro Fertilization (IVF) Cycles.
Status: COMPLETED
Conditions: Endometriosis|Infertility
Interventions: DRUG: Leuprolide|PROCEDURE: IVF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalising and Refining Neo-adjuvant Chemotherapy in Locally Advanced But Resecable Colon Cancer in the Elderly of 70 Years Old or More
Status: RECRUITING
Conditions: Colon Cancer
Interventions: DRUG: Folfox|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retroclavicular Approach vs Infraclavicular Approach for Plexic Bloc Anesthesia of the Upper Limb
Status: COMPLETED
Conditions: Hand Injury
Interventions: OTHER: Ultrasound guided retroclavicular block|OTHER: Ultrasound guided infraclavicular block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acute Normovolemic Hemodilution (ANH) in Patients Undergoing Cardiac Surgery
Status: COMPLETED
Conditions: Surgery--Complications|Blood Transfusion Complication
Interventions: PROCEDURE: Acute Normovolemic Hemodilution (ANH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Cell Phone Exposure on Immediate Attention Levels and Concentration of Emergency Physicians
Status: UNKNOWN
Conditions: Acute Effects of EMWs Emitted by Cell Phones
Interventions: RADIATION: Electromagnetic field of cell phone in ''on'' mode.|RADIATION: Electromagnetic field of cell phone in 'off' mode.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetic Study of Aztreonam-Avibactam in Severe Renal Impairment
Status: COMPLETED
Conditions: Renal Insufficiency
Interventions: DRUG: Aztreonam-Avibactam|DRUG: Aztreonam-Avibactam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Fruquintinib Plus FOLFIRI in RAS-mutated Metastatic Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: intensive treatment|DRUG: Maintenance treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Aldurazyme in Patients With Mucopolysaccharidosis (MPS) I
Status: COMPLETED
Conditions: Mucopolysaccharidosis I|Hurlers Syndrome|Hurler-Scheie Syndrome
Interventions: BIOLOGICAL: rhIDU (recombinant human-Alpha-L-Iduronidase)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Parecoxib on Postoperative Shoulder Pain After Gynecological Laparoscopy.
Status: COMPLETED
Conditions: Anti-Inflammatory Agents, Non-Steroidal|Pain, Postoperative|Laparoscopy
Interventions: DRUG: parecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Clinical Outcomes POD L GF vs POD F GF in Asian Eyes
Status: COMPLETED
Conditions: Cataract|Lens Opacities|Presbyopia
Interventions: DEVICE: IOL implantation experimental|DEVICE: IOL implantation active comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STEP-ED: Reducing Duration of Untreated Psychosis and Its Impact in the U.S.
Status: COMPLETED
Conditions: Psychosis|Schizophrenia
Interventions: BEHAVIORAL: Early Detection (ED)|BEHAVIORAL: Usual Detection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebrolysin as an Add-On Therapy to Standard Treatment of Basilar Artery Occlusion
Status: NOT_YET_RECRUITING
Conditions: Basilar Artery Occlusion|Posterior Circulation Brain Infarction
Interventions: DRUG: Cerebrolysin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Performance of HepaSphere Transarterial Chemoembolization Combined With Hepatic Arterial Infusion Chemotherapy on Unresectable Colorectal Liver Metastases
Status: NOT_YET_RECRUITING
Conditions: Colorectal Liver Metastases (CRCLM)
Interventions: PROCEDURE: DEB-TACE plus HAIC
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Determine Safety and Effectiveness of Tadalafil on Prostate Related Sex Organ/Urinary Tract Problems
Status: COMPLETED
Conditions: Prostatic Hyperplasia|Prostate
Interventions: DRUG: tadalafil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Bioavailability of a Food Supplement Rich in Melatonin Administered Sublingually and Orally (MELATONIN)
Status: COMPLETED
Conditions: Biological Availability
Interventions: DIETARY_SUPPLEMENT: Melatonin oral administration|DIETARY_SUPPLEMENT: Melatonin sublingual administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Immunogenicity Among Healthy Children Receiving Fluzone® Quadrivalent Influenza Virus Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Fluzone® Quadrivalent Influenza Virus Vaccine, No Preservative|BIOLOGICAL: Fluzone® Quadrivalent Influenza Virus Vaccine, No Preservative
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: THrombolysis for Acute Wake-up and Unclear-onset Strokes With Alteplase at 0.6 mg/kg Trial (THAWS)
Status: UNKNOWN
Conditions: Stroke
Interventions: DRUG: Tissue-type plasminogen activator (alteplase)|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Hyaluronic Acid Gel Injection for Improvement of Scar Quality Following Reduction Mammaplasty
Status: WITHDRAWN
Conditions: Cicatrix
Interventions: DEVICE: Hyaluronic acid gel|DEVICE: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT