pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Renal Transplantation Nurse Training on Patient-Centered Care Competence and Counseling Skills
Status: NOT_YET_RECRUITING
Conditions: Kidney Transplantation|Nursing|Education|Care|Counseling
Interventions: BEHAVIORAL: Traning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety Study of Satralizumab (SA237) as Add-on Therapy to Treat Participants With Neuromyelitis Optica (NMO) and NMO Spectrum Disorder (NMOSD)
Status: COMPLETED
Conditions: Neuromyelitis Optica (NMO)|NMO Spectrum Disorder (NMOSD)
Interventions: DRUG: Satralizumab|DRUG: Placebo|DRUG: Baseline Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Incentive Spirometer and Pursed Lip Breathing After Whipple Procedure.
Status: RECRUITING
Conditions: Hospital Stay
Interventions: OTHER: Pursed Lip Breathing|OTHER: Incentive Spirometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Hemoperfusion in Acute Type A Aortic Dissection Patients Undergoing Aortic Arch Operation (HPAO)
Status: UNKNOWN
Conditions: Acute Type A Aortic Dissection With Arch Involvement|Cardiopulmonary Bypass|Deep Hypothermic Circulatory Arrest
Interventions: DEVICE: Hemoperfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Genotype Expression and Phenotype of Endothelial Cells, Carrying an ACVRL1, ENG or SMAD4 Mutation, in Response to BMP9 for the Identification of New Therapeutic Targets in Hereditary Haemorrhagic Telangiectasia
Status: COMPLETED
Conditions: Hereditary Haemorrhagic Telangiectasia
Interventions: BIOLOGICAL: Cord blood sampling|BIOLOGICAL: Cord blood sampling|BIOLOGICAL: Cord sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interscalene Nerve Blocks With Ropivacaine Alone, With Dexamethasone, Plus Systemic Dexamethasone
Status: TERMINATED
Conditions: Pain
Interventions: DRUG: Ropivacaine|DRUG: dex|DRUG: Bupivacaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CI-1040 in Treating Patients With Advanced Breast, Colon, Pancreatic, or Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Breast Cancer|Colorectal Cancer|Lung Cancer|Pancreatic Cancer
Interventions: DRUG: CI-1040
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Neural Substrates of Emotion: Impact of Cocaine Dependence
Status: COMPLETED
Conditions: Cocaine Use Disorder
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spinraza in Adult Spinal Muscular Atrophy
Status: RECRUITING
Conditions: Spinal Muscular Atrophy|Spinal Muscular Atrophy Type II|Spinal Muscular Atrophy Type 3
Interventions: DRUG: Observational study to examine safety, tolerability, and effectiveness of SPINRAZA® prescribed as part of standard of care|OTHER: One time survey
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comparison of Three Regimens of Acute Pain Management: Methoxyflurane; Intranasal Fentanyl; Intravenous Morphine
Status: COMPLETED
Conditions: Acute Pain|Ambulances
Interventions: DRUG: Methoxyflurane|DRUG: Fentanyl|DRUG: Morphine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PI3K Inhibitor BKM120 and Cetuximab in Treating Patients With Recurrent or Metastatic Head and Neck Cancer
Status: COMPLETED
Conditions: Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma|Recurrent Metastatic Squamous Neck Cancer With Occult Primary|Recurrent Salivary Gland Cancer|Recurrent Squamous Cell Carcinoma of the Hypopharynx|Recurrent Squamous Cell Carcinoma of the Larynx|Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity|Recurrent Squamous Cell Carcinoma of the Nasopharynx|Recurrent Squamous Cell Carcinoma of the Oropharynx|Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Recurrent Verrucous Carcinoma of the Larynx|Recurrent Verrucous Carcinoma of the Oral Cavity|Salivary Gland Squamous Cell Carcinoma|Stage IV Squamous Cell Carcinoma of the Hypopharynx|Stage IV Squamous Cell Carcinoma of the Nasopharynx|Stage IVA Salivary Gland Cancer|Stage IVA Squamous Cell Carcinoma of the Larynx|Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVA Squamous Cell Carcinoma of the Oropharynx|Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVA Verrucous Carcinoma of the Larynx|Stage IVA Verrucous Carcinoma of the Oral Cavity|Stage IVB Salivary Gland Cancer|Stage IVB Squamous Cell Carcinoma of the Larynx|Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVB Squamous Cell Carcinoma of the Oropharynx|Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVB Verrucous Carcinoma of the Larynx|Stage IVB Verrucous Carcinoma of the Oral Cavity|Stage IVC Salivary Gland Cancer|Stage IVC Squamous Cell Carcinoma of the Larynx|Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVC Squamous Cell Carcinoma of the Oropharynx|Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVC Verrucous Carcinoma of the Larynx|Stage IVC Verrucous Carcinoma of the Oral Cavity|Tongue Cancer
Interventions: DRUG: PI3K inhibitor BKM120|BIOLOGICAL: cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Radiation Therapy in Treating Patients With Cancer of the Esophagus
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: DRUG: chemotherapy|DRUG: cisplatin|DRUG: fluorouracil|RADIATION: brachytherapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of 12 Weeks of Acupuncture on AMH and COH in Low Responder Patients
Status: UNKNOWN
Conditions: Hypogonadism; Ovarian|Female Infertility
Interventions: OTHER: acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of a Booster Dose of the SpikoGen Vaccine in Kidney Transplant Recipients After Two Doses of Sinopharm Vaccine
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: SARS-CoV-2 recombinant spike protein + Advax-SM adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Acid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase Deficiency
Status: COMPLETED
Conditions: Lysosomal Acid Lipase Deficiency
Interventions: DRUG: Sebelipase Alfa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Functional Impact of a Close-loop Controlled Prehension Neuroprosthesis in Post-stroke Patients
Status: RECRUITING
Conditions: Stroke
Interventions: DEVICE: Prehension neuroprosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase 3 Study of GSK548470 in Patients With Compensated Chronic Hepatitis B Untreated With Nucleic Acid Analogue
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: GSK548470 300 mg tablet|DRUG: ETV 0.5 mg capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Medications in the Treatment of Postmenopausal Women With Osteoporosis
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal
Interventions: DRUG: teriparatide 20 micrograms/day subcutaneous|DRUG: salmon calcitonin 100 IU/day subcutaneous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Strategies of Oropharyngeal and Tracheal Suctioning in Mechanically Ventilated Patients
Status: COMPLETED
Conditions: Ventilator Acquired Pneumonia|Aspiration
Interventions: PROCEDURE: Optimized oral care|OTHER: Routine oral care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Safety and Efficacy of a Microneedle Device for Local Anesthesia
Status: COMPLETED
Conditions: Local Anesthesia|Intradermal Injections
Interventions: DEVICE: MicronJet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Safety and Efficacy of Radio Frequency (Forma Eye) Treatment for Dry Eye Disease Due to Meibomian Gland Dysfunction
Status: COMPLETED
Conditions: Improvement of Dry Eye Disease
Interventions: DEVICE: Forma Eye Applicator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Diagnostic Standards in Dysphagia
Status: COMPLETED
Conditions: Dysphagia
Interventions: PROCEDURE: Fiberoptic Endoscopic Evaluation of Swallowing|PROCEDURE: Videofluoroscopic Swallowing Study|PROCEDURE: Voluntary Peak Cough Flow Testing|PROCEDURE: Iowa Oral Performance Instrument|PROCEDURE: Capsaicin Challenge|PROCEDURE: Pulmonary Function Testing|OTHER: Voicing Tasks
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Preliminary Efficacy of JK500 Cell Injection in Relapsed/Refractory Pediatric Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia, Childhood|Relapsed Leukemia|Refractory Leukemia
Interventions: DRUG: JK500 cell injection，cyclophosphamide，Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Tocofersolan (Vedrop®) to Prevent or Treat Refractive Vitamin E Deficiency in Infants and Children
Status: WITHDRAWN
Conditions: Short Bowel Syndrome|Vitamin E Deficiency
Interventions: DRUG: Tocofersolan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 18 to 75 Years of Age Treated With Intravenous (IV) Infusion and Subcutaneous (SC) Injections of ABBV-154 for Moderately to Severely Active Crohn's Disease
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: DRUG: ABBV-154|DRUG: Placebo|DRUG: ABBV-154|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Three Doses of a Controlled Release Formulation of Varenicline for Smoking Cessation
Status: WITHDRAWN
Conditions: Smoking Cessation
Interventions: DRUG: Varenicline Controlled Release 1.2 mg|DRUG: Varenicline Controlled Release 1.8 mg|DRUG: Varenicline Controlled Release 2.4 mg|DRUG: Varenicline Immediate Release 1 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preservation of Venous Valvular Function After PMT for Acute DVT
Status: ENROLLING_BY_INVITATION
Conditions: Acute Deep Venous Thrombosis of Femoral Vein (Disorder)
Interventions: DEVICE: AngioJet device|OTHER: anticoagulation alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zoledronic Acid to Prevent Bone Loss During Androgen Deprivation Therapy for Prostate Cancer
Status: COMPLETED
Conditions: Bone Loss|Prostate Cancer
Interventions: DRUG: Zoledronic acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: RecurIndex Guided Avoidance of Regional Nodal Irradiation for Node Positive Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Radiation
Interventions: RADIATION: regional nodal irradiation|RADIATION: WBI|RADIATION: chestwall XRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CAR-T-cell Treatment for Untreated High Risk MANtle Cell Lymphoma
Status: RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: KTE-X19|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Exercise With Virtual Reality in Hemodialysis Patients
Status: NOT_YET_RECRUITING
Conditions: Kidney Failure, Chronic
Interventions: OTHER: Exercise with non-immersive virtual reality|OTHER: Exercise with a static pedal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Novel Smoking Cessation Drug for Schizophrenia
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Active JNJ Drug|DRUG: Placebo Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prospective Randomized Trial Comparing THD Versus Stapler Operation for 3rd Degree Hemorrhoids
Status: UNKNOWN
Conditions: Hemorrhoids
Interventions: PROCEDURE: Transanal doppler hemorrhoidal ligation|PROCEDURE: stapled hemorrhoidopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomised, Double- Blind, Cross-over Efficacy and Safety Comparison of Three Different Doses of Tiotropium Administered Once Daily Versus Placebo in Patients With Moderate Persistent Asthma.
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: tiotropium bromide 2.5µg once daily|DRUG: Tiotropium matching Placebo once daily|DRUG: tiotropium bromide high dose once daily|DRUG: tiotropium bromide 1.25µg once daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: New Biomarkers in Facioscapulohumeral Muscular Dystrophy, Multispectral Optoacoustic Tomography.
Status: RECRUITING
Conditions: FSHD
Interventions: DEVICE: MSOT Acuity Echo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Drug-drug Interaction of Empagliflozin (BI 10773) and Microgynon
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: levonorgestrel|DRUG: levonorgestrel|DRUG: Ethinylestradiol|DRUG: Microgynon + BI 10773|DRUG: Ethinylestradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BOOST: Study of Increased Dosage of Lopinavir/Ritonavir (LPV/r)
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: Increased dose of Kaletra
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Electrical Performances Evaluation of Navigo Leads Equipped With IS4 Connector
Status: UNKNOWN
Conditions: Arrythmia, Implatable Cardioverter Defibrillation, Lead
Interventions: DEVICE: NAVIGO 4LV lead implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Interferon Alpha Treatment for Oral Ulcers of Behcet's Disease
Status: COMPLETED
Conditions: Behcet Syndrome|Behcet Disease|Mucocutaneous Ulceration
Interventions: BIOLOGICAL: Veldona,
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Biomarkers Impact on Participants Response to Erlotinib Treatment for First-line Non-Small Cell Lung Cancer With Endothelial Growth Factor Receptor (EGFR) Activating Mutations
Status: COMPLETED
Conditions: Carcinoma，Non-Small-Cell Lung
Interventions: DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Multivitamin Supplements on Clinical and Immunological Response in Childhood Tuberculosis
Status: TERMINATED
Conditions: Tuberculosis
Interventions: DIETARY_SUPPLEMENT: Multivitamin supplement containing vitamins B, C, and E|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized Feedback After Alcohol Health Education for Members of Greek Life (GREEK Study)
Status: ENROLLING_BY_INVITATION
Conditions: College Student Drinking
Interventions: BEHAVIORAL: e-checkup to go|BEHAVIORAL: Delayed feedback booster
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prospective RCT Lidocaine & Levobupivacaine on Block Dynamics After Subparaneural Popliteal Sciatic Nerve Block
Status: RECRUITING
Conditions: Musculoskeletal Diseases or Conditions
Interventions: DRUG: 0.5% Levobupivacaine|DRUG: 2% Xylocaine with adrenaline 1:200,000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Doxorubicin With or Without Ifosfamide and Pegfilgrastim in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Sarcoma
Interventions: BIOLOGICAL: pegfilgrastim|DRUG: doxorubicin hydrochloride|DRUG: ifosfamide|PROCEDURE: multimodality therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-finding Study of Novel Erythropoiesis Stimulating Protein (NESP) for the Treatment of Anaemia in Subjects With Solid Tumours Receiving Multicycle Chemotherapy
Status: COMPLETED
Conditions: Anemia|Solid Tumors
Interventions: DRUG: Placebo|DRUG: Novel Erythropoiesis Stimulating Protein (NESP) (darbepoetin alfa)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Diabetic Peripheral Neuropathic Pain Who Had an Inadequate Response to Pregabalin
Status: RECRUITING
Conditions: Diabetic Peripheral Neuropathic Pain
Interventions: DRUG: HSK16149 20mg BID|DRUG: Pregabalin 150mg BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Asimadoline to Treat Diarrhea-Predominant Irritable Bowel Syndrome (D-IBS)
Status: COMPLETED
Conditions: Diarrhea Predominant Irritable Bowel Syndrome
Interventions: DRUG: Asimadoline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Risk Factors and Severe COVID-19. A Nationwide Registry-based Case-Control Study
Status: UNKNOWN
Conditions: COVID-19
Interventions: OTHER: Hypertension|OTHER: Diabetes type 2|OTHER: Obesity|DRUG: Antihypertensive Agents|DRUG: Statins (Cardiovascular Agents)|OTHER: Chronic kidney disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Photobiomodulation in Individuals With Chronic Obstructive Pulmonary Disease
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: RADIATION: Low level laser therapy|PROCEDURE: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Three Treatment Combinations Using Zidovudine Plus Lamivudine Plus Indinavir in HIV-Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Indinavir sulfate|DRUG: Lamivudine|DRUG: Stavudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Pediatric Ilioinguinal / Iliohyogogastric Nerve Block
Status: UNKNOWN
Conditions: Intra-operative Anesthesia and Analgesia Effects
Interventions: DRUG: ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study Comparing the Efficacy of L19TNF+Doxorubicin vs Doxorubicin Alone as First-line Therapy in Patients With Advanced or Metastatic Soft Tissue Sarcoma
Status: RECRUITING
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: Onfekafusp alfa|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Corneal Hysteresis and Corneal Resistance Factor After Corneal Cross-linking for Keratoconus
Status: COMPLETED
Conditions: Progressive Keratoconus
Interventions: PROCEDURE: Corneal collagen cross-linking|DEVICE: Ocular Response Analyzer (ORA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose:
Clinical trial: The Effect of Atorvastatin on Renal Function in Healthy Subjects During Normal and High Sodium Intake
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Camostat Mesylate in COVID-19 Outpatients
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Camostat Mesilate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phototoxic Doses of Ultraviolet A for Treatment of Alopecia Areata
Status: COMPLETED
Conditions: Alopecia Areata
Interventions: RADIATION: ultraviolet A (UVA)|DRUG: Triamcinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Substantial Equivalence of iSlpr™ and SomnoDent® Classic in the Treatment of Snoring and Mild to Moderate Sleep Apnoea.
Status: UNKNOWN
Conditions: Sleep Apnea|Snoring
Interventions: DEVICE: iSlpr™|DEVICE: SomnoDent® Classic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Myocet/Lapatinib Study. ICORG 10-03, V5
Status: TERMINATED
Conditions: Her2 Positive Metastatic Breast Cancer
Interventions: DRUG: non-pegylated liposomal doxorubicon (Myocet™)|DRUG: Lapatinib (Tyverb™)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET Study of Cerebral Metabolism of 11C-acetoacetate and 18F-FDG in Patients Under Moderate Ketosis
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Pre-KD|DIETARY_SUPPLEMENT: Post-KD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dose Finding Study of Post-BMT Decitabine Maintenance Treatment in Higher-risk MDS and MDS/AML
Status: UNKNOWN
Conditions: Myelodysplastic Syndrome|Acute Myeloid Leukemia
Interventions: DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ropustin for Refractory Aplastic Anaemia After Radiotherapy - a Single-centre, Prospective, Open-label, Single-arm Study
Status: NOT_YET_RECRUITING
Conditions: Aplastic Anemia
Interventions: DRUG: Romiplostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pedal@Work: A Worksite Wellness Program
Status: COMPLETED
Conditions: Physical Activity
Interventions: BEHAVIORAL: Pedal@Work Worksite Wellness|BEHAVIORAL: Pedal@Work
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neurophysiological Mechanisms of Accelerated Resolution Therapy (ART)
Status: UNKNOWN
Conditions: Depressive Symptoms|Stress Disorder, Acute|Prolonged Grief Disorder|Alcohol Abuse|Stress Disorders, Post-Traumatic
Interventions: BEHAVIORAL: Accelerated Resolution Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate the Pharmacokinetic Characteristics of Luckyvec 400mg Tablet, in Healthy Subjects
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia|Gastrointestinal Stromal Tumors
Interventions: DRUG: Luckyvec 400mg film coated tablet|DRUG: Glivec 100mg film coated tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Remimazolam Tosilate in Patients Undergoing Diagnostic Upper GI Endoscopy
Status: COMPLETED
Conditions: Sedation
Interventions: DRUG: Remimazolam Tosilate|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study in Asthma Patients to Evaluate Efficacy, Safety and Tolerability of 14 Days Once Daily Inhaled Interferon Beta-1a After the Onset of Symptoms of an Upper Respiratory Tract Infection
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Interferon beta-1a Nebuliser solution 48 μg/mL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Feasibility Study of Transcutaneous Tibial Nerve Stimulation for Urinary Symptoms in People With Multiple Sclerosis
Status: COMPLETED
Conditions: Bladder Dysfunction|Neurogenic Bladder Dysfunction|Urinary Incontinence|Urinary Bladder, Overactive|Urinary Incontinence, Urge|Nocturia|Urinary Frequency More Than Once at Night|Lower Urinary Tract Symptoms|Multiple Sclerosis|Urinary Bladder, Neurogenic
Interventions: DEVICE: Transcutaneous tibial nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of DE-089 Ophthalmic Solution in Patients With Dry Eye
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: diquafosol ophthalmic solution|DRUG: 0.1% sodium hyaluronate ophthalmic solution.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Potential Effects of SSR149415 on the Hypothalamic-pituitary-adrenal Axis in Outpatients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: VASOPRESSIN V1B RECEPTOR ANTAGONIST (SSR149415)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Washed Microbiota Transplantation for Allergic Rhinitis
Status: NOT_YET_RECRUITING
Conditions: Rhinitis, Allergic
Interventions: DRUG: Washed Microbiota Transplantation|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The True Efficacy of Burst Spinal Cord Stimulation in the Management of Intractable Low Back Pain (TRU-BURST)
Status: WITHDRAWN
Conditions: Chronic Intractable Pain
Interventions: DEVICE: BurstDR-SCS|DEVICE: BurstDR-SCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ultrasound-guided Stellate Ganglion Block Combined With Facial Nerve and Glossopharyngeal Nerve Block on the Treatment of Sudden Deafness
Status: RECRUITING
Conditions: Sudden Deafness
Interventions: PROCEDURE: Stellate ganglion block|PROCEDURE: Facial and glossopharyngeal nerve blocks|DRUG: Mecobalamin Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Chemotherapy With or Without GnRH Agonist for Premenopausal Triple-negative Early Breast Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: Triple Negative Breast Cancer|Premenopausal Breast Cancer
Interventions: DRUG: Goserelin Acetate 3.6mg、Goserelin Acetate 10.8mg、Leuprolide Acetate 3.75mg、Leuprorelin Acetate 22.5mg、Triptorelin pamoate 11.25mg、Triptorelin pamoate 22.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxycodone DETERx™ Versus Placebo in Chronic Low Back Pain (CLBP)
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: DRUG: Oxycodone DETERx|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Clinical Evaluation of Three Different Agents in Reducing Dental Hypersensitivity in Periodontal Patients
Status: COMPLETED
Conditions: Dentin Hypersensitivity|Periodontal Diseases
Interventions: DRUG: Sensodyne Repair and Protect|DRUG: Dentalclean Daily Regenerator|DRUG: Dentalclean Daily Regenerator with potassium citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ED50 Determination of Hydroxyethylstarch for Treatment of Hypotension During Cesarean Section Under Spinal Anesthesia
Status: UNKNOWN
Conditions: Obstetric Anesthesia|Spinal Anesthesia|Hypotension|Fluid Therapy|Cesarean Section
Interventions: DRUG: Hydroxyethylstarch 130/0.4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Tauroursodeoxycholic Acid Versus Ursofalk in the Treatment of Adult Primary Biliary Cirrhosis
Status: COMPLETED
Conditions: Primary Biliary Cirrhosis
Interventions: DRUG: Tauroursodeoxycholic Acid Capsules|DRUG: Ursodeoxycholic Acid Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Next-Generation Recombinant Factor IX Variant in Adult Subjects With Hemophilia B
Status: COMPLETED
Conditions: Hemophilia B
Interventions: BIOLOGICAL: Coagulation Factor IX variant|BIOLOGICAL: Coagulation Factor IX variant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UK Baby Study Using a Baby Wash and Lotion Regimen
Status: TERMINATED
Conditions: Newborns
Interventions: OTHER: Cosmetic Products
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 1, Study of the Safety and Tolerability of ALV003 in Healthy Adult Volunteers and Subjects With Well-Controlled Celiac Disease
Status: COMPLETED
Conditions: Celiac Disease
Interventions: DRUG: 4 dose levels of ALV003
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Probiotics in Chronic Periodontitis
Status: COMPLETED
Conditions: Chronic Periodontitis|Probiotics
Interventions: DIETARY_SUPPLEMENT: P Flor locally delivered|DIETARY_SUPPLEMENT: P Flor systemically administered|DRUG: Amoxil 500 mg Oral Capsule|DRUG: Flagyl 400 mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Safety, Efficacy, and Tolerability of Brexpiprazole in Treating Agitation Associated With Dementia of the Alzheimer's Type
Status: COMPLETED
Conditions: Agitation Associated With Alzheimer's Dementia|Alzheimer Dementia
Interventions: DRUG: Brexpiprazole|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Canagliflozin Targeting Vascular Inflammation
Status: NOT_YET_RECRUITING
Conditions: Diabetes Type 2|Coronary Artery Disease
Interventions: DRUG: Canagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Intravenous or Subcutaneous Mircera for the Treatment of Anemia in Dialysis Patients
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: epoetin alfa or beta|DRUG: methoxy polyethylene glycol-epoetin beta [Mircera]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: It's Time to Address Fear of Cancer Recurrence in Family Caregivers: Online Version of the Fear Of Recurrence Therapy
Status: COMPLETED
Conditions: Cancer|Caregiver|CBT|Fear Cancer
Interventions: BEHAVIORAL: Family Caregiver - Fear Of Recurrence Therapy (FC-FORT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Periodontitis in Critically Ill Patients: Diagnosis and Epidemiology
Status: COMPLETED
Conditions: Chronic Periodontitis|Intensive Care Unit
Interventions: PROCEDURE: Dental examination and a point of care P. gingivalis test (Denka Seiken Co (Japan) )
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination Chemotherapy in Treating Younger Patients With Hodgkin Lymphoma
Status: COMPLETED
Conditions: Lymphoma|Neurotoxicity
Interventions: DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: prednisolone|DRUG: procarbazine hydrochloride|DRUG: vincristine sulfate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Music Therapy for Speech and Prosody in Autistic Children (MTSPAC)
Status: NOT_YET_RECRUITING
Conditions: Autism|Language Delay|Speech Disorders in Children
Interventions: BEHAVIORAL: music therapy, speech therapy|BEHAVIORAL: speech therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Surgeon-Modified Stent Grafts forTreatment of Complex Aortic Aneurysms
Status: NOT_YET_RECRUITING
Conditions: Thoracoabdominal Aneurysm|Juxtarenal Aortic Aneurysm|Pararenal Aneurysm|Aortic Aneurysm|Failed Previous Infrarenal Repairs (Failed EVAR)
Interventions: DEVICE: Surgeon-Modified fenestrated stent grafts using Cook Zenith Platform (Zfen, TX2, Alpha Thoracic Endovascular Graft and Zenith Flex)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Efficacy of Peginesatide for Maintenance Treatment of Anemia in Participants With Chronic Kidney Disease on Hemodialysis
Status: COMPLETED
Conditions: Chronic Renal Failure|Chronic Kidney Disease|Anemia
Interventions: DRUG: peginesatide|DRUG: Epoetin alfa or Epoetin beta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GEMOX Combined With Donafenib and Tislelizumab in Advanced Biliary Tract Carcinoma
Status: RECRUITING
Conditions: Biliary Tract Carcinoma
Interventions: COMBINATION_PRODUCT: Combination of Gemcitabine, Oxaliplatin, Donafenib and Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temozolomide, Cisplatin, and Nivolumab in People With Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Adenocarcinoma
Interventions: DRUG: Temozolomide (TMZ)|DRUG: Cisplatin|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Safety and Efficacy of the VDyne Transcatheter Tricuspid Valve Replacement System for the Treatment of Tricuspid Regurgitation ( VISTA-US)
Status: RECRUITING
Conditions: Tricuspid Regurgitation|Tricuspid Valve Disease|Tricuspid Valvular Disorders
Interventions: DEVICE: VDyne Transcatheter Tricuspid Valve Replacement System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Predictors of Successful Oral Dissolution Therapy in Radiolucent Renal Stones; A Prospective Evaluation
Status: COMPLETED
Conditions: Urolithiasis|Renal Stones
Interventions: DRUG: Oral alkalinization (Potassium citrate, Allopurinol)|BEHAVIORAL: Life style modification|DIETARY_SUPPLEMENT: Dietary recommendations (decrease purine rich diet as red meat and fish, increase vegetables)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: tDCS Effects on Resisting Smoking: Dose Ranging Study
Status: COMPLETED
Conditions: Nicotine Addiction
Interventions: DEVICE: transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Anesthetic Depth and Postoperative Delirium Trial - 2
Status: COMPLETED
Conditions: Delirium|Cognitive Disorders
Interventions: OTHER: Processed EEG-guided anesthetic depth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Lumasiran in Children and Adults With Primary Hyperoxaluria Type 1
Status: COMPLETED
Conditions: Primary Hyperoxaluria Type 1 (PH1)
Interventions: DRUG: Placebo|DRUG: Lumasiran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Vitamin E Ovules for the Treatment of Hemorrhoids
Status: UNKNOWN
Conditions: Bleeding Anal|Pain|Stings
Interventions: DRUG: Vitamin E ovules|DRUG: Prednisolone ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing the Efficacy and Safety of Anakinra Versus Intravenous Immunoglobulin (IVIG) Retreatment, in Patients With Kawasaki Disease Who Failed to Respond to Initial Standard IVIG Treatment
Status: RECRUITING
Conditions: Kawasaki Disease
Interventions: DRUG: ANAKINRA|DRUG: Intravenous immunoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Utilizing Patient-Reported and Radiographic Outcomes and Evaluating the Safety and Efficacy of Lorecivivint (SM04690) for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: Lorecivivint|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectıveness Of Structured Myofascial Chain Exercise Training After Anterior Cruciate Ligament Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injuries|Anterior Cruciate Ligament Rupture|Anterior Cruciate Ligament Tear
Interventions: OTHER: Exercise Therapy For Lower Extremities|OTHER: Exercise Therapy For Myofascial Chains
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Systemic Methylprednisolone in Chronic Rhinosinusitis
Status: COMPLETED
Conditions: Chronic Rhinosinusitis|Children
Interventions: DRUG: methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OptiLUTS Part C: The Development of a Symptom Assessment Tool in Sacral Neuromodulation.
Status: COMPLETED
Conditions: Overactive Bladder Syndrome|Urinary Retention|Dysfunctional Voiding|Fecal Incontinence|Fowler Syndrome
Interventions: DEVICE: Sacral neuromodulation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hematologic Response of Epoetin Alfa (PROCRIT) Versus Darbepoetin Alfa (ARANESP) in Chemotherapy Induced Anemia
Status: COMPLETED
Conditions: Anemia|Chemotherapy
Interventions: DRUG: Epoetin alfa and Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-centre Study of Entonox Versus Midazolam Sedation in Gastroscopy
Status: UNKNOWN
Conditions: Patients Requiring Diagnostic Gastroscopy With Sedation
Interventions: DRUG: Entonox|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Male Circumcision for HIV Prevention in Rakai, Uganda
Status: COMPLETED
Conditions: HIV Infections|Herpesvirus 2, Human|Syphilis|Genital Diseases, Male
Interventions: PROCEDURE: Adult male circumcision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Arabinoxylan-oligosaccharides (AXOS) for the Management of Type-2 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Type 2
Interventions: DIETARY_SUPPLEMENT: AG+XOS+AXOS|DIETARY_SUPPLEMENT: Placebo Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Rapid Escalation of Cabergoline in Comparison to Conventional Dosing in Prolactin Secreting Macroadenomas.
Status: UNKNOWN
Conditions: Macroprolactinoma
Interventions: DRUG: Cabergoline|DRUG: cabergoline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ixabepilone Compared With Mitoxantrone and Prednisone in Treating Patients With Refractory Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Prostate|Recurrent Prostate Cancer|Stage IV Prostate Cancer
Interventions: DRUG: ixabepilone|DRUG: mitoxantrone hydrochloride|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The ORIGIN Trial (Outcome Reduction With Initial Glargine Intervention)
Status: COMPLETED
Conditions: Diabetes Mellitus, Non-Insulin-Dependent
Interventions: DRUG: insulin glargine (HOE901)|DRUG: omega-3 polyunsaturated fatty acids (PUFA)|DRUG: placebo|DEVICE: reusable pen device for insulin injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy Study of Umeclidinium/Vilanterol With Tiotropium/Olodaterol in COPD Patients
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: UMEC/VI|DRUG: TIO/OLO|DRUG: Albuterol/salbutamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing a Barbershop-based HIV Prevention Initiative Among Men
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections
Interventions: BEHAVIORAL: General, status-neutral HIV education|DIAGNOSTIC_TEST: HIV self-test kits|OTHER: Information about where to receive HIV prevention services|BEHAVIORAL: Barber-led peer support group education|BEHAVIORAL: Facility-based HIV risk reduction counseling|DIAGNOSTIC_TEST: Facility-based HIV testing|OTHER: Information about facility distributed HIV self-test kits|DIAGNOSTIC_TEST: STI testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION