pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Immunological Profile and Microbial Markers in Evaluating the Effectiveness of Probiotic Therapy in RA Patients
Status: NOT_YET_RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DIETARY_SUPPLEMENT: probiotic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Rehabilitative Effects of Curved-walking Training in Stroke, Parkinson and Orthopaedic Populations
Status: UNKNOWN
Conditions: Stroke, Acute|Parkinson Disease|Femur Fracture
Interventions: OTHER: Novel locomotion treatment: curved-walking training|OTHER: Standard locomotion treatment: straight-walking training|OTHER: Standard physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Low-intensity Interval Walking With Blood Flow Restriction on Functional Capacity in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: OTHER: BFR-Walking|OTHER: Conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telemental Health and Cognitive Processing Therapy for Female Veterans With Military-related PTSD
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Cognitive Processing Therapy in-person|BEHAVIORAL: Cognitive Processing Therapy through videoteleconference
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of TECH: Tablet Enhancement of Cognition and Health
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: OTHER: TECH: Tablet Enhancement of Cognition and Health protocol|OTHER: Standard care or active standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Families Together: Intervention for Reunified Families
Status: ACTIVE_NOT_RECRUITING
Conditions: Child Abuse|Child Neglect
Interventions: BEHAVIORAL: Promoting First Relationships ®|OTHER: Resource & Referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Second Bowel Preparation for Colonoscopy Failure
Status: TERMINATED
Conditions: Colonoscopy Failure|Poor Bowel Preparation
Interventions: DRUG: polyethylene glycol, Bisacodyl|DRUG: polyethylene glycol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: THE EFFECT OF PERİNEUM MASSAGE WİTH OLİVE OİL ON PERİNEUM INTEGRİTY AND DURATİON OF SECOND PERİOD OF DELİVERY
Status: COMPLETED
Conditions: Prevention
Interventions: OTHER: Perineum massage with olive oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Oral Semaglutide on Bone Turnover in Patients With T2D: a Randomized Placebo-controlled Clinical Trial
Status: RECRUITING
Conditions: Type 2 Diabetes|Osteopenia
Interventions: DRUG: oral Semaglutide/Rybelsus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Different Dose Levels of GlaxoSmithKline (GSK) Biologicals' Investigational Respiratory Syncytial Virus (RSV) Vaccine (GSK3888550A), Based on the Vaccine Safety and the Antibodies (Body Defences) Produced Following Vaccine Administration, When Given to Healthy Non-pregnant Women
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: GSK3888550A RSV Maternal vaccine formulation 1|BIOLOGICAL: GSK3888550A RSV Maternal vaccine formulation 2|BIOLOGICAL: GSK3888550A RSV Maternal vaccine formulation 3|DRUG: Placebo (Normal Saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: KRYSTAL- KetopRofen lYsinate Sore ThroAt Lozenges
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: KETOPROFEN(RP19583)|DRUG: KETOPROFEN(RP19583)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short Acting Agents Vs Long Acting in Frequent Excerbator COPD Patients
Status: NOT_YET_RECRUITING
Conditions: Copd
Interventions: DRUG: SABA SAMA ICS Vs LABA LAMA ICs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate Efficacy and Safety of a New Suffocating Head Lice Product.
Status: UNKNOWN
Conditions: Head Lice|Pediculosis Capitis
Interventions: DEVICE: X92001752|DEVICE: RID Super Max Solution|DRUG: Nix Crème|DEVICE: Pouxit Végétal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of Novel A2A Agonist in Treatment of Diabetic Neuropathic Pain
Status: COMPLETED
Conditions: Diabetic Neuropathic Pain
Interventions: DRUG: BVT.115959|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pertuzumab in Addition to Chemotherapy and Trastuzumab as Adjuvant Therapy in Participants With Human Epidermal Growth Receptor 2 (HER2)-Positive Primary Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: 5-Fluorouracil|DRUG: Carboplatin|DRUG: Cyclophosphamide|DRUG: Docetaxel|DRUG: Doxorubicin|DRUG: Epirubicin|DRUG: Paclitaxel|DRUG: Pertuzumab|DRUG: Placebo|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Incision Laparoscopic Gastric Banding Versus Conventional Five Port Laparoscopic Gastric Banding
Status: COMPLETED
Conditions: Morbid Obesity
Interventions: PROCEDURE: Laparoscopic gastric banding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Phototherapy by Light-emitting Diode Therapy (LEDT) on Clinical, Biochemical and Biomechanical of Muscle Performance in Athletes
Status: COMPLETED
Conditions: Athlete
Interventions: DEVICE: Light-emitting diode therapy|DEVICE: Placebo light-emitting diode therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Glycopyrrolate Bromide of COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: CHF 5259|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PHS, Lichtenstein Mesh, and PerFixPlug for Primary Inguinal Hernia Repair - 3 Years Results
Status: COMPLETED
Conditions: Hernia, Inguinal
Interventions: PROCEDURE: Lichtenstein mesh|PROCEDURE: PerFix Plug®|PROCEDURE: Prolene® Hernia System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Toward Zero Prescribed Opioids for Outpatient General Surgery
Status: COMPLETED
Conditions: Opioid Misuse and Addiction|Pain
Interventions: DRUG: Oxycodone|BEHAVIORAL: Zero Opioid Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Vitamin D and Omega-3 Supplementation on Telomeres in VITAL
Status: UNKNOWN
Conditions: Aging
Interventions: DIETARY_SUPPLEMENT: Vitamin D3 (cholecalciferol)|DRUG: fish oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Improving Nutrition and Physical Activity for Cancer Survivors (Tools To Be Fit)
Status: RECRUITING
Conditions: Bladder Cancer|Breast Cancer|Colon Cancer|Endometrial Cancer|Ovarian Cancer|Rectal Cancer|Prostate Cancer|Renal Cell Carcinoma|Kidney Cancer
Interventions: OTHER: Counseling|OTHER: Educational Intervention|BEHAVIORAL: Health Education|OTHER: Health Promotion and Education - Direct Text Messaging|OTHER: Health Promotion and Education - Digital health tool kit|OTHER: Questionnaires|PROCEDURE: Optional Blood Specimen|PROCEDURE: Optional Stool Specimens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Electrical Impedance Scanning of Thyroid Nodules Prior to Thyroid Surgery: a Prospective Study
Status: COMPLETED
Conditions: Thyroid Neoplasms|Thyroid Nodules
Interventions: DEVICE: Electrical Impedance Scanning (EIS) of the Thyroid gland
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of Auricular Vagus Nerve Stimulation in Painful Covid Long
Status: RECRUITING
Conditions: COVID-19
Interventions: DEVICE: Tens Eco Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy Study of Herceptin to Treat HER2-negative CTC Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Human Epidermal Growth Factor 2 Negative Carcinoma of Breast|Circulating Tumor Cells
Interventions: DRUG: trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Pregabalin (Lyrica®) to Placebo in Pain Relief After Photorefractive Keratectomy (PRK) Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Stem/Stromal Cells in Neurological Disorders and Disease
Status: UNKNOWN
Conditions: Dementia|Parkinson|Altered Behavior in Alzheimer Disease|Demyelinating Autoimmune Diseases, CNS|Demyelinating Sensorimotor Neuropathy|Corticobasal Degeneration
Interventions: PROCEDURE: Microcannula Harvest Adipose|DEVICE: Centricyte 1000|PROCEDURE: Sterile Normal Saline Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Effects of Diabetes Self-Management Education and Nutritional Supplementation on Visual Function and Retinopathy
Status: UNKNOWN
Conditions: Diabetes Mellitus|Diabetic Retinopathy
Interventions: DIETARY_SUPPLEMENT: EyePromise DVS, EyePromise DVS plus EyePromise EZTears
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Arthroscopic Rotator Cuff Repair: Suture Anchors Versus Arthroscopic Transosseous Fixation
Status: COMPLETED
Conditions: Rotator Cuff Tears
Interventions: DEVICE: Arthroscopic transosseous fixation|DEVICE: Suture anchors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of a Double Isolation Perfusion Schedule Using Melphalan Alone for Intransit Melanoma or Unresectable Sarcoma of the Extremity
Status: COMPLETED
Conditions: Melanoma|Sarcoma
Interventions: PROCEDURE: double isolated limb perfusion with melphalan alone
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Resatorvid in Patients With Sepsis-induced Cardiovascular and Respiratory Failure
Status: TERMINATED
Conditions: Sepsis
Interventions: DRUG: Resatorvid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Parental Involvement in Pain Reducing Measures
Status: COMPLETED
Conditions: Procedural Pain|Preterm Infants|Parents
Interventions: BEHAVIORAL: Passive parental involvement|RADIATION: Active parental involvement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality-Reward Training for Anhedonia
Status: RECRUITING
Conditions: Positive Affect|Depression
Interventions: BEHAVIORAL: Virtual Reality-Reward Training (VR-RT)|BEHAVIORAL: Virtual Reality-Memory Training (VR-MT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MALE HAIR LOSS - Treatment With Dutasteride Mesotherapy x Dutasteride MMP Technique (Injections With Tattoo Machine)
Status: RECRUITING
Conditions: Androgenic Alopecia
Interventions: PROCEDURE: MESOTHERAPY (INJECTIONS WITH SYRINGE AND NEEDLE)|PROCEDURE: MMP (INJECTIONS WITH A TATTOO MACHINE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Semi-personalized IM Smoking Cessation Interventions
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Instant Messaging (IM)|BEHAVIORAL: AWARD advice|BEHAVIORAL: NRT sampling|BEHAVIORAL: Active referral|BEHAVIORAL: SMS messaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Integrase and Maraviroc Intensification in Neurocognitive Dysfunction (InMIND)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Placebo for maraviroc (MVC)|DRUG: Placebo for dolutegravir (DTG)|DRUG: Dolutegravir (DTG)|DRUG: Maraviroc (MVC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-Marketing Clinical Study of Postoperative Adjuvant Therapy With Imatinib Mesylate in Patients With Gastrointestinal Stromal Tumors (GIST)
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumors
Interventions: DRUG: Imatinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study Examining Migranal and Skin Sensitivity in Subjects With Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Migranal nasal spray at 1 hour|DRUG: Migranal nasal spray at 4 hour
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Long-Term Safety of Vildagliptin as Monotherapy in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Vildagliptin|DRUG: Vildagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Valemetostat Tosylate as a Single Agent in Patients With Relapse/Refractory B-cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma, B-Cell
Interventions: DRUG: Valemetostat tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety, PK, and Preliminary Effects on Scar Formation of Multiple Intradermal Administrations of RXI-109
Status: COMPLETED
Conditions: Cicatrix|Scar Prevention
Interventions: DRUG: RXI-109|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Extracorporeal Shockwave Lithotripsy on Hypertension
Status: WITHDRAWN
Conditions: Hypertension|Renal Stone
Interventions: PROCEDURE: Extracorporeal shock wave lithotripsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Audit-and-feedback to Improve Antimicrobial-prescribing Among Urologists
Status: COMPLETED
Conditions: Urologic Diseases|Antibacterial Drug Adverse Reaction
Interventions: BEHAVIORAL: Audit-and-feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Trial of Intravesical Therapy for Interstitial Cystitis in Patients With Generalized Vulvodynia
Status: WITHDRAWN
Conditions: Vulvodynia
Interventions: DRUG: Bladder instillation with heparin/ lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Osteo-periosteal Cylinder Graft Transplantation for Hepple V Osteochondral Lesions of the Talus
Status: ENROLLING_BY_INVITATION
Conditions: Osteochondral; Defect
Interventions: PROCEDURE: autologous osteo-periosteal cylinder graft transplantation|PROCEDURE: autologous osteochondral graft transplantation|DEVICE: autologous osteo-periosteal cylinder graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Dolutegravir-based Regimen on Early Mortality of AIDS Patients
Status: COMPLETED
Conditions: Severely Immunocompromised HIV Patients
Interventions: DRUG: Dolutegravir 50 mg|DRUG: Efavirenz-based regimens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Chemotherapy-Induced Hair Changes and Alopecia, Skin Aging and Nail Changes in Women With Non-Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Metastatic Breast Cancer
Interventions: OTHER: Clinical Assessments|BEHAVIORAL: Questionnaires|OTHER: Saliva sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: High-Dose Melphalan and a Second Stem Cell Transplant or Low-Dose Cyclophosphamide in Treating Patients With Relapsed Multiple Myeloma After Chemotherapy
Status: UNKNOWN
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: cyclophosphamide|DRUG: melphalan|PROCEDURE: autologous hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Absorption, Metabolism, and Routes of Excretion Following Oral Administration of (14C) Radiolabeled JNJ--42756493 to Healthy Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-42756493
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bioequivalence Study of Doxycycline Monohydrate 100mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Doxycycline monohydrate 100mg tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Impact of an Atrial Fibrillation Decision Support Tool (AFDST) on Thromboprophylaxis for Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation|Atrial Flutter
Interventions: BEHAVIORAL: Decision Support|BEHAVIORAL: Educational Intervention Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: New Tablet Containing Two FDA Approved Anti-HIV Drugs For Antiretroviral Therapy Experienced HIV-1 Infected Subjects
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus I|HIV Infection
Interventions: DRUG: abacavir/lamivudine|DRUG: abacavir|DRUG: lamivudine|DRUG: tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapidly Absorbing Polyglactin 910 Versus Poliglecaprone 25 for Laceration Repair
Status: COMPLETED
Conditions: Dyspareunia|Perineal Tear|Sutured Laceration
Interventions: PROCEDURE: Laceration Repair with Polyglactin 910|PROCEDURE: Laceration Repair with poliglecaprone 25
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vitamin B12 Supplementation in Diabetic Neuropathy
Status: COMPLETED
Conditions: Diabetes Mellitus|Diabetic Neuropathies|Diabetic Complication|Diabetic Foot
Interventions: DIETARY_SUPPLEMENT: B12 fix 1000mcg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics in the Management of Acute Rotavirus Diarrhea in Bolivian Children
Status: COMPLETED
Conditions: Diarrhea|Rotavirus Infection
Interventions: DRUG: GB (Florestor)|DRUG: GRALB|DRUG: GC (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Single and Multiple Doses of IkT-148009 in Healthy Elderly Participants and Parkinson's Patients
Status: COMPLETED
Conditions: Healthy Elderly|Parkinson Disease
Interventions: DRUG: IkT-148009|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Propofol and Remifentanyl Versus Midazolam and Fentanyl for Diagnostic Colonoscopy in Patients With Compensated Cirrhosis Child A-B
Status: UNKNOWN
Conditions: Liver Disease
Interventions: DRUG: Propofol and Remifentnyl|DRUG: midazolam and fentanyl|DRUG: midazolam anf fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Serum Bovine Immunoglobulin in Improving Nutritional Status in Advanced COPD
Status: COMPLETED
Conditions: Advanced COPD (GOLD Stage 3 or 4) With Cachexia
Interventions: DIETARY_SUPPLEMENT: Serum bovine immunoglobulin (SBI) medical food|DIETARY_SUPPLEMENT: Placebo (for serum bovine immunoglobulin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of a Stretching Program of the Rib Cage Muscles on Patients With COPD During Exercise
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: Stretching|OTHER: Control|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Diagnostics and Intervention Services for Parkinson's Disease
Status: NOT_YET_RECRUITING
Conditions: Brain Diseases|Central Nervous System Diseases|Nervous System Diseases|Joint Diseases|Musculoskeletal Diseases|Parkinson Disease|Basal Ganglia Diseases|Movement Disorders|Synucleinopathies|Neuro-Degenerative Disease|Demyelinating Disease, Autoimmune, CNS|Demyelinating Disease|Autoimmune Diseases|Immune System Diseases|Bone Diseases, Metabolic|Bone Diseases|Arthritis|Osteoporosis|Multiple Sclerosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Insulin Detemir on Blood Glucose Control in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin detemir|DRUG: insulin NPH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors
Status: RECRUITING
Conditions: Solid Tumors|Neuroblastoma|Rhabdomyosarcoma|Ewing Sarcoma|Hepatoblastoma|Medulloblastoma
Interventions: DRUG: VAL-413|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expanded Access Study of Fenretinide Lym-X-Sorb Plus Ketoconazole in Neuroblastoma
Status: NO_LONGER_AVAILABLE
Conditions: Recurrent Neuroblastoma|Neuroblastoma
Interventions: DRUG: Fenretinide Lym-X-Sorb Oral Powder|DRUG: Ketoconazole
Study Type: EXPANDED_ACCESS
Clinical trial: Trial of CUDC-907 in Children and Young Adults With Relapsed or Refractory Solid Tumors, CNS Tumors, or Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma|Neuroblastoma|Brain Tumor|Solid Tumor
Interventions: DRUG: CUDC-907
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multistrain Probiotics Reduces UC Depression and Anxiety Scores
Status: UNKNOWN
Conditions: Ulcerative Colitis
Interventions: DIETARY_SUPPLEMENT: a multistrain probiotic product (DSF)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Canada Lymph Node Score Project: A Crossover Trial
Status: COMPLETED
Conditions: Lung Cancer|Non Small Cell Lung Cancer|Non-small Cell Lung Cancer Stage I|Non-small Cell Lung Cancer Stage II
Interventions: DIAGNOSTIC_TEST: Selective Targeted Sampling|DIAGNOSTIC_TEST: Systematic Sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Tramadol Versus Diclofenac for Prevention of Pain in Operative Outpatient Hysteroscopy
Status: UNKNOWN
Conditions: Pain
Interventions: DRUG: Tramadol|DRUG: Diclofenac|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Chronic Electrical Stimulation of the Auditory Cortex for Intractable Tinnitus
Status: COMPLETED
Conditions: Hearing Disorders|Hearing Loss|Hyperacusis|Tinnitus
Interventions: PROCEDURE: significant chronic primary auditory cortex stimulation during the first two weeks|PROCEDURE: non significant chronic primary auditory cortex stimulation during the first two weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Side Branch Predilatation Strategy in Coronary Bifurcation Lesion Stenting (SBPS)
Status: UNKNOWN
Conditions: Coronary Ostium Stenosis|Myonecrosis
Interventions: PROCEDURE: SB predilatation|PROCEDURE: No SB predilatation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of Dapagliflozin in Subjects With Type 2 Diabetes Who Have Inadequate Glycaemic Control on Background Combination of Metformin and Sulfonylurea
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|High HbA1c Level|Inadequate Glycaemic Control
Interventions: DRUG: dapagliflozin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neostigmine as an Adjuvant in Tranversus Abdominis Plane (TAP) Block in Cesarean Section Under Spinal Anesthesia
Status: NOT_YET_RECRUITING
Conditions: Analgesia
Interventions: DRUG: Bupivacaine-Neostigmine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison Between Single and Triple Rubber Band Ligation for the Treatment of Hemorrhoids
Status: UNKNOWN
Conditions: Second-degree Hemorrhoids
Interventions: PROCEDURE: Single hemorrhoidal ligation|PROCEDURE: Triple hemorrhoidal ligation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Progression of Bacterial Conjunctivitis Symptoms Upon Antibiotic Treatment
Status: COMPLETED
Conditions: Bacterial Conjunctivitis
Interventions: DRUG: Vigamox Ophthalmic Solution|DRUG: BSS placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: S0112 Cytarabine and Daunorubicin in Treating Older Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: sargramostim|DRUG: cytarabine|DRUG: daunorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Assess the Anti-inflammatory Effects of Roflumilast in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: COPD|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Roflumilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Detection of Children With Developmental Disabilities in Assiut Governorate
Status: COMPLETED
Conditions: Developmental Disability|Development Delay|Motor Delay|Down Syndrome|Autism Spectrum Disorder
Interventions: OTHER: Nurses training program on early detection of disability
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Research Study to Look at How Insulin Icodec and Semaglutide Work in the Body of People From China With Type 2 Diabetes When Given Alone or Together
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: IcoSema|DRUG: insulin icodec|DRUG: semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve Dysfunction
Status: RECRUITING
Conditions: Complex Congenital Heart Defect|Dysfunctional RVOT Conduit|Pulmonary Valve Insufficiency|Pulmonary Valve Degeneration
Interventions: DEVICE: SAPIEN 3/SAPIEN 3 Ultra RESILIA THV|DEVICE: SAPIEN 3 THV|DEVICE: SAPIEN 3 Ultra RESILIA THV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of F-652 (IL-22:IgG2 Fusion Protein) in Patients With Moderate to Severe COVID-19
Status: TERMINATED
Conditions: Covid19
Interventions: BIOLOGICAL: F-652|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Timing of Umbilical Cord Clamping on Haematological and Clinical Outcomes of Infants
Status: COMPLETED
Conditions: Anemia|Ferritin|Complications|Hemorrhage|Jaundice
Interventions: PROCEDURE: Early Cord Clamping|PROCEDURE: Delayed Cord Clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of a Flushing ASsessment Tool (FAST) in Subjects Receiving Niacin Extended-release Plus Aspirin
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: Niacin extended-release (NER)|DRUG: Niacin extended-release (NER) placebo|DRUG: Aspirin (ASA)|DRUG: Aspirin (ASA) placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study to Investigate the Benefits of an Improved Deferasirox Formulation (Film-coated Tablet)
Status: COMPLETED
Conditions: Chronic Iron Overload Due to Transfusion-dependant Anemias
Interventions: DRUG: Deferasirox dispersible tablet|DRUG: Defearisox film-coated tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anlotinib Combined With Concurrent Chemoradiotherapy in the Treatment of Locally Advanced Cervical Cancer
Status: NOT_YET_RECRUITING
Conditions: To Evaluate the Efficacy and Safety of Anlotinib Combined With Concurrent Chemoradiotherapy in the Treatment of Locally Advanced Cervical Cancer
Interventions: DRUG: Hydrochloride anlotinib|DRUG: cis Platinum/carboplatin|RADIATION: External beam radiotherapy and brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of the Training Programme Based on the Health Promotion Model Given to Parents
Status: NOT_YET_RECRUITING
Conditions: Parents|Epilepsy in Children|Disease Management
Interventions: OTHER: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: T-Cell Replete Haploidentical Donor Hematopoietic Stem Cell Plus Natural Killer (NK) Cell Transplantation in Patients With Hematologic Malignancies Relapsed or Refractory Despite Previous Allogeneic Transplant
Status: TERMINATED
Conditions: Acute Lymphoblastic Leukemia|Acute Myelocytic Leukemia|Chronic Myelocytic Leukemia|Juvenile Myelomonocytic Leukemia|Myelodysplastic Syndrome|Hodgkin or Non-Hodgkin Lymphoma|Sarcoma, Myeloid
Interventions: DRUG: clofarabine|DRUG: cytarabine|DRUG: busulfan|DRUG: Plerixafor|DRUG: cyclophosphamide|DRUG: antithymocyte globulin (rabbit)|BIOLOGICAL: stem cells|DRUG: Tacrolimus|DRUG: mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effectiveness of Home and Hospital-based PR in Candidate Patients With BLVR
Status: COMPLETED
Conditions: Emphysema|Bronchoscopic Lung Volume Reduction|Hospital-based Pulmonary Rehabilitation|Home-based Pulmonary Rehabilitation
Interventions: OTHER: Hospital-based pulmonary rehabilitation|OTHER: Home-based pulmonary rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for Peripheral Neuropathy Induced by Paclitaxel in Early Stage Breast Cancer
Status: COMPLETED
Conditions: Peripheral Neuropathy Due to Chemotherapy
Interventions: OTHER: True acupuncture|OTHER: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prevention of Adult Caries Study (PACS)
Status: COMPLETED
Conditions: Caries, Dental
Interventions: DRUG: 10% w/v chlorhexidine acetate coating FDA IND #45466|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Restore-B: A Trial Comparing Prepectoral Implant-based Breast Reconstruction With and Without Mesh
Status: ENROLLING_BY_INVITATION
Conditions: Breast Cancer|Risk Reduction
Interventions: PROCEDURE: Prepectoral implant-based immediate breast reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Chemotherapy Compared With Observation in Treating Patients With Resected Early Stage Ovarian Epithelial Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: DRUG: carboplatin|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Deployment of Functional Optical Brain Monitor [fNIR] in Clinical Anesthesia
Status: COMPLETED
Conditions: Surgical Procedures, Operative
Interventions: DEVICE: fNIR light emitting and sensing device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: One, Two, or Three iStents for the Reduction of Intraocular Pressure in Open-angle Glaucoma Subjects
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma (POAG)
Interventions: DEVICE: iStent|DEVICE: iStent|DEVICE: iStent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Pharmacogenetics-based Adaptive Dosing of 5-fu (5-Fluorouracile) in Head & Neck Cancer Patient Undergoing Docetaxel, Cisplatin, 5-Fluorouracile (=TPF) Therapy
Status: COMPLETED
Conditions: Patients With Head and Neck Cancer (ORL)
Interventions: DRUG: Cisplatin|DRUG: Docetaxel|DRUG: 5-Fluorouracile
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Targeted IL-13 Rα2 or B7-H3 UCAR-T for Advanced Glioma
Status: RECRUITING
Conditions: Advanced Glioma|Complication of Chimeric Antigen Receptor (CAR-T) Cell Therapy
Interventions: BIOLOGICAL: Targeted IL-13 Rα2 UCAR-T cell injection|BIOLOGICAL: Targeted B7-H3 UCAR-T cell injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quadratus Lumborum Block : Effect on Acute Pain and Quality of Recovery After Laparoscopic Adrenalectomy
Status: TERMINATED
Conditions: Pain Management|Nerve Block|Laparoscopic Adrenalectomy
Interventions: PROCEDURE: single-injection QLB(quadratus lumborum block)|PROCEDURE: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Training to Enhance Adaptation and Management for Wheelchair Users (TEAMWheels)
Status: RECRUITING
Conditions: Mobility Limitation
Interventions: BEHAVIORAL: TEAM Wheels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Safety of Lubiprostone in Pediatric Participants Aged ≥ 6 Years to < 18 Years With Functional Constipation
Status: COMPLETED
Conditions: Constipation - Functional
Interventions: DRUG: Lubiprostone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemotherapy With Carboplatin and Docetaxel in Patients With Advanced Ovarian Cancer-Prospective, Randomized Phase II Clinical Trial
Status: UNKNOWN
Conditions: Ovarian Neoplasms
Interventions: PROCEDURE: neoadjuvant chemotherapy (Carboplatin/Docetaxel)|PROCEDURE: neoadjuvant chemotherapy (Carboplatin/Docetaxel)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Participant and Healthcare Professional Reported Preference for Subcutaneous Atezolizumab Compared With Intravenous Atezolizumab Formulation in Participants With Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High vs Low Intensity Virtual Reality Gait Training in Individuals With Chronic Stroke
Status: NOT_YET_RECRUITING
Conditions: Stroke|Gait Disorders, Neurologic
Interventions: OTHER: Virtual reality gait training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation
Status: COMPLETED
Conditions: Acute Respiratory Failure|Intubation Complication
Interventions: DRUG: intravenous crystalloid fluid, 500 mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of ARO-CFB in Adult Healthy Volunteers and Patients With Complement-Mediated Kidney Disease
Status: RECRUITING
Conditions: IgA Nephropathy
Interventions: DRUG: ARO-CFB|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerance to Target Doses of Thiazides in Actual Practice: A Feasibility Study
Status: COMPLETED
Conditions: Hypertension
Interventions: OTHER: Favor one of two thiazides for new prescriptions & attempt target dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Chemotherapy, Imatinib Mesylate, and Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Adult Acute Lymphoblastic Leukemia in Remission
Interventions: DRUG: imatinib mesylate|DRUG: methotrexate|DRUG: vincristine sulfate|DRUG: leucovorin calcium|PROCEDURE: peripheral blood stem cell transplantation|PROCEDURE: autologous hematopoietic stem cell transplantation|PROCEDURE: allogeneic hematopoietic stem cell transplantation|RADIATION: total-body irradiation|DRUG: tacrolimus|BIOLOGICAL: filgrastim|DRUG: etoposide|DRUG: cyclophosphamide|DRUG: cytarabine|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Satisfaction of Insulin Glargine Plus Insulin Apidra Compared With NPH Insulin Plus Insulin Apidra in Recently Diagnosed Type 1 Diabetes Children and Adolescents
Status: TERMINATED
Conditions: Diabetes Type 1
Interventions: DRUG: insulin Glargine + Insulin Apidra|DRUG: Insulin NPH + Insulin Apidra: Active Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Gd-EOB-DTPA MRI for Detection and Characterization of Liver Nodules in Cirrhotic Patients Undergoing Liver Transplantation and Potential Impact on Transplant Eligibility
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DIAGNOSTIC_TEST: Primovist MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Induction Dosing With PEGASYS (Peginterferon Alfa-2a [40KD]) Plus Copegus in Treatment-Naive Patients With Chronic Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: peginterferon alfa-2a|DRUG: Ribavirin|DRUG: peginterferon alfa-2a|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rescue Emetic Therapy for Children Having Elective Surgery
Status: WITHDRAWN
Conditions: Post Operative Nausea and Vomiting|Rescue Emetic Therapy
Interventions: DRUG: Metaclopramide|DRUG: Ondansetron|DRUG: diphenhydramine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Assess the Efficacy and Safety of OTX-DED for the Short-term Treatment of Signs and Symptoms of Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: OTX-DED|DRUG: OTX-DED|DRUG: OTX-DED
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Non-Blinded Study Demonstrating the Effectiveness and Safety of Azilect Alone or in Combination Therapy in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: rasagiline mesylate|DRUG: Rasagiline mesylate plus Mirapex|DRUG: Rasagiline mesylate with Levodopa|DRUG: Rasagiline mesylate with Requip
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity of Influenza Vaccinations
Status: NOT_YET_RECRUITING
Conditions: Influenza
Interventions: BIOLOGICAL: Flucelvax (ccIIV4)|BIOLOGICAL: Flublok (RIV) or Fluzone (IIV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Respiratory Rehabilitation Based on Eccentric Exercice on Treadmill After Thoracic Surgery
Status: RECRUITING
Conditions: Thoracic Surgery|Breathing|Muscle
Interventions: OTHER: Retraining program after thoracic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Time in Range (TIR) and Time Below Range (TBR) in Insulin-Treated Elderly Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Continuous Glucose Monitoring
Interventions: DEVICE: Application of the FreeStyle Libre Flash Glucose CGM.|DIAGNOSTIC_TEST: InBody 270 multifrequency bioimpedance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p