pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Ropidoxuridine and Whole Brain Radiation Therapy in Treating Patients With Brain Metastases
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm|Metastatic Malignant Neoplasm in the Brain
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|OTHER: Quality-of-Life Assessment|DRUG: Ropidoxuridine|RADIATION: Whole-Brain Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential or Up-front Triple Treatment With Durvalumab, Tremelimumab and Bevacizumab for Non-resectable Hepatocellular Carcinoma (HCC) Patients
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: durvalumab, tremelimumab, bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preparation of Patients for Cardiac Surgery
Status: COMPLETED
Conditions: Coronary Artery Bypass Graft Surgery|Cardiac Valve Surgery
Interventions: DIETARY_SUPPLEMENT: Metabolic therapy|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation the Effects of Stabilization Exercises on Pain, Disability and Activity of Pelvic Floor Muscles in Patients With Postpartum Lumbopelvic Pain
Status: COMPLETED
Conditions: Postpartum Lumbopelvic Pain
Interventions: OTHER: Stabilization exercise|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Daily or Weekly Cladribine in Treating Patients With Hairy Cell Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: 2-chlorodeoxyadenosine (CDA) daily|DRUG: 2-chlorodeoxyadenosine weekly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromodulation Enhanced Cognitive Restructuring: A Proof of Concept Study
Status: COMPLETED
Conditions: Anxiety|Depression|Personality Disorders|Trauma and Stress-related Disorders|Somatic Disorders|Obsessive Compulsive Disorders|Eating Disorders|Difficulties With Cognitive Emotion Regulation
Interventions: BEHAVIORAL: Cognitive Restructuring|DEVICE: rTMS|DEVICE: Sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Opioid Free Anesthesia in ENT Surgery
Status: UNKNOWN
Conditions: Functional Endoscopic Sinus Surgery
Interventions: DRUG: Dexmedetomidine|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of GM602 in Patients With Acute Middle Cerebral Artery Ischemic Stroke Within 18 Hours
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: GM602|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Unrelated And Partially Matched Related Donor PSCT w/ T Cell Receptor (TCR) αβ Depletion for Patients With BMF
Status: RECRUITING
Conditions: Acquired Aplastic Anemia|Paroxysmal Nocturnal Hemoglobinuria|Inherited Bone Marrow Failure Syndromes
Interventions: DEVICE: CliniMACs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cervical Unilateral Antero-posterior Mobilization and Thoracic Central Postro-anterior Mobilization in Treatment of Shoulder Impingement Syndrome
Status: NOT_YET_RECRUITING
Conditions: Shoulder Impingement
Interventions: OTHER: therapeutic exercises|OTHER: mobilization exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Angioplasty of the Tibial Arteries Augmented Radio Frequency Denervation of the Popliteal Artery
Status: TERMINATED
Conditions: Сhronic Ischemia of the Lower Extremities|Atherosclerosis of the Tibial Arteries|Lesion no More Than Two Tibial Arteries|Steno-occlusive Lesion of the Tibial Arteries
Interventions: PROCEDURE: angioplasty tibial arteries|PROCEDURE: angioplasty tibial arteries augmented radio frequency denervation popliteal artery by the use"Vessix Renal Denervation System Balloon"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Everolimus + Very Low Tacrolimus vs Enteric-coated Mycophenolate Sodium + Low Tacrolimus in de Novo Renal Transplant
Status: COMPLETED
Conditions: Transplantation Infection|Cytomegalovirus Infections
Interventions: DRUG: Everolimus|DRUG: Very Low Tacrolimus|DRUG: Low Tacrolimus|DRUG: Steroids|DRUG: Thymoglobulin|DRUG: Sodium Mycophenolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Optimal Treatment on Hepatocellular Carcinoma (HCC) With Cirrhotic Portal Hypertension
Status: COMPLETED
Conditions: Hepatocellular Carcinoma(HCC)|Cirrhotic Portal Hypertension
Interventions: PROCEDURE: Precise hepatectomy|OTHER: Combined intervention (chemoembolization/ablation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Using Interactive Consulting System to Enhance Informed Choice
Status: RECRUITING
Conditions: Age-related Cataract
Interventions: OTHER: An interactive chatbot for patient decision aid|OTHER: Senior ophthalmologists
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bioavailability Investigations of Thyronajod Mite Tablets of Dosage Strengths 50 μg Levothyrox-ine/75 μg Iodine, and 100 μg Levothyroxine/75 μg Iodine vs. a Levothyroxine Drinking-Solution: A Randomised Cross Over Study in Healthy Male Individuals. Currently: 100 μg/ 75 μg Tablets
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: levothyroxine|DRUG: levothyroxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Thrombin Generation Assay (TGA) as Predictive Test for Haemostatic. Effectiveness of FVIII Concentrates in Haemophiliac A With Inhibitors
Status: UNKNOWN
Conditions: Severe Hemophilia A With Inhibitor
Interventions: OTHER: TGA (Thrombin generation Assay)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Incidence of the Intravascular Injection During S1 Transforaminal Epidural Steroid Injection in Two Approaches: Medial vs Lateral in Anteroposterior View
Status: COMPLETED
Conditions: Lumbosacral Radicular Pain
Interventions: DRUG: S1 transforaminal epidural steroid(dexamethasone) injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Repeat PET/CT Imaging of Patients With Amyloid 124I-AT-01 to Measure Changes in Organ-specific Amyloid Load
Status: ACTIVE_NOT_RECRUITING
Conditions: Systemic Amyloidosis
Interventions: DRUG: Injection of peptide p5+14 radiolabeled with iodine-124 (124I-AT-01)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bevacizumab Plus Fluorouracil and Leucovorin in Treating Patients With Locally Advanced or Metastatic Stage IV Colorectal Cancer That Has Progressed After Standard Chemotherapy
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: fluorouracil|DRUG: leucovorin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Childhood Risk Reduction Program in Hispanics
Status: COMPLETED
Conditions: Breast Feeding, Exclusive
Interventions: BEHAVIORAL: Early Childhood Obesity Risk-Reduction Program in Hispanics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Biological Responses Affecting Early-stage Dental Implant Placement in Patients With History of Periodontitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Periodontitis|Peri-implant Mucositis|Peri-Implantitis
Interventions: OTHER: Megagen implant placement|OTHER: Biomate-Swiss implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study in Healthy Men to Test How Well Different Doses of BI 1819479 Are Tolerated
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1819479|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Vascularity Changes of Scars With Laser Therapy
Status: COMPLETED
Conditions: Hypertrophic Scar
Interventions: DEVICE: pulsed dye laser|OTHER: standardized care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Compare Sirolimus Versus Tacrolimus In De Novo Simultaneous Pancreas- Kidney Allograft Recipients Receiving An Induction Therapy With Antithymocyte Globulin Plus Mycophenolate Mofetil Plus Corticosteroids
Status: UNKNOWN
Conditions: Pancreas Transplantation|Kidney Transplantation
Interventions: DRUG: Sirolimus|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Exemestane +/- MM-121 in Postmenopausal Women With Locally Advanced or Metastatic Estrogen Receptor Positive and/or Progesterone Receptor Positive Her2 Negative Breast Cancer
Status: COMPLETED
Conditions: Her2 Negative Breast Cancer Patients
Interventions: DRUG: MM-121|DRUG: Placebo|DRUG: Exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Hepalatide in Chronic Hepatitis D(CHD) Patients
Status: COMPLETED
Conditions: Chronic Hepatitis D Infection
Interventions: DRUG: Hepalatide|DRUG: Hepalatide Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of Histopathological Factors Predictive of Lymph Node Involvement and Management Practices in pT1 Colorectal Cancers Treated by Primary Endoscopic Resection
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer|Colorectal Adenocarcinoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess Change in Disease Activity, Adverse Events, and How the Drug Moves Through the Body in Adult Participants Living With Human Immunodeficiency Virus (HIV) Receiving Intravenous (IV) Infusion of Budigalimab and/or ABBV-382
Status: RECRUITING
Conditions: Human Immuno-deficiency Virus (HIV) Disease
Interventions: DRUG: Budigalimab|DRUG: Placebo for Budigalimab|DRUG: ABBV-382|DRUG: Placebo for ABBV-382
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Elobixibat Colonic Motor Function Study
Status: WITHDRAWN
Conditions: Chronic Idiopathic Constipation
Interventions: DRUG: elobixibat|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to See Whether Stereotactic Body RadioTherapy (SBRT) Can Shrink Tumours Within the Liver Safely
Status: UNKNOWN
Conditions: Colonic Neoplasms|Neoplasm Metastasis
Interventions: RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hospital Management of Hyperglycemia Study of Insulin Glargine Plus Insulin Lispro Versus Human Regular Insulin
Status: TERMINATED
Conditions: Hyperglycemia
Interventions: DRUG: Human regular insulin|DRUG: Insulin lispro|DRUG: Insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigational Scan (Magnetic Resonance Elastography) in Detecting Treatment Response in Patients With Advanced Liver Cancer
Status: RECRUITING
Conditions: Advanced Adult Hepatocellular Carcinoma|Stage III Hepatocellular Carcinoma AJCC v8|Stage IIIA Hepatocellular Carcinoma AJCC v8|Stage IIIB Hepatocellular Carcinoma AJCC v8|Stage IV Hepatocellular Carcinoma AJCC v8|Stage IVA Hepatocellular Carcinoma AJCC v8|Stage IVB Hepatocellular Carcinoma AJCC v8
Interventions: PROCEDURE: Magnetic Resonance Elastography|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: PIMPmyHospital: a Mobile App to Improve Emergency Care Efficiency and Communication
Status: COMPLETED
Conditions: Pediatric Emergency Medicine|Communication
Interventions: DEVICE: PIMPmyHospital (mHealth tool)|OTHER: Conventional method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Of Panobinostat In Children With Refractory Hematologic Malignancies
Status: COMPLETED
Conditions: Lymphoblastic Leukemia, Acute, Childhood|Myelogenous Leukemia, Acute, Childhood|Hodgkin's Disease|Non-Hodgkin's Lymphoma
Interventions: DRUG: Panobinostat|DRUG: Cytarabine|DRUG: Panobinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Double Injection Erector Spinae Plane Block on Postoperative Pain Following Breast Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Breast Cancer
Interventions: OTHER: Erector Spinae Plane Block|DEVICE: Intravenous Morphine patient controlled analgesia device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Obatoclax Mesylate, Rituximab, and Bendamustine Hydrochloride in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma
Status: WITHDRAWN
Conditions: Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Splenic Marginal Zone Lymphoma
Interventions: DRUG: bendamustine hydrochloride|DRUG: obatoclax mesylate|BIOLOGICAL: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Tasimelteon in Subjects With Renal Impairment and Matched Control Subjects With Relatively Normal Renal Function
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Tasimelteon|DRUG: Tasimelteon
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nutritional Supplementation in Children Aged 1-3 Years Experiencing Growth Concerns
Status: COMPLETED
Conditions: Growth|Learning|Toddlers
Interventions: OTHER: Fortified Cow's Milk-Based Oral Nutritional Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Bacillus Subtilis ATCC 122264 Supplementation on Gas Symptoms and Quality of Life in Participants With Functional Bloating
Status: COMPLETED
Conditions: Functional Bloating
Interventions: DIETARY_SUPPLEMENT: Bacillus subtilis ATCC 122264|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Different Anesthesia Maintain Protocol Effect the Outcome of the Patients
Status: COMPLETED
Conditions: Urinary Surgery|General Anesthesia
Interventions: DRUG: Propofol|DRUG: 1% Sevoflurane|DRUG: 1% Sevoflurane continue|DRUG: Sufentanil|DRUG: 2% Sevoflurane|DRUG: Propofol half
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults
Status: RECRUITING
Conditions: Glioblastoma|Malignant Glioma|Recurrent Glioblastoma|Recurrent Malignant Glioma|Recurrent Grade III Glioma|Grade III Glioma
Interventions: BIOLOGICAL: Nivolumab|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Double-blind, Group-comparison Study Using Zolpidem (Myslee) as a Comparative Drug in Patients With Insomnia
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders|Sleep Disorders
Interventions: DRUG: Zolpidem MR|DRUG: Zolpidem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Single Dose of Inhaled Sargramostim in Patients With Autoimmune Pulmonary Alveolar Proteinosis
Status: COMPLETED
Conditions: Autoimmune Pulmonary Alveolar Proteinosis
Interventions: DRUG: Sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bioavailability of BI 44370 TA Drinking Solution or Tablets With and Without a High Fat Meal in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 44370 powder for oral solution|DRUG: BI 44370 tablet|OTHER: high fat breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tick-borne Encephalitis and Borrelial Antibodies in Serum
Status: RECRUITING
Conditions: Tick Borne Encephalitis
Interventions: DRUG: Doxycycline|DRUG: Symptomatic therapy|OTHER: Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Overall Response Rate by Inducing an Inflammatory Phenotype in Metastatic BReast cAnCEr With the Oncolytic Reovirus PeLareorEp in CombinaTion With Anti-PD-L1 Avelumab and Paclitaxel - BRACELET-1 Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer Metastatic
Interventions: DRUG: Paclitaxel|BIOLOGICAL: Pelareorep|DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bovine Colostrum to Prevent Absorption of Gluten
Status: RECRUITING
Conditions: Celiac Disease|Gluten Sensitivity|Non-celiac Gluten Sensitivity
Interventions: DIETARY_SUPPLEMENT: Bovine colostrum|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: HIIE and Abdominal Fat Mass in DT2 Postmenopausal Women
Status: UNKNOWN
Conditions: Type 2 Diabetes|Overweight (BMI > 25)|Postmenopausal Women
Interventions: PROCEDURE: Physical activity programs steady-state exercise (SSE) program|PROCEDURE: Physical activity programs high intensity intermittent exercise (HIIE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Targeting Default Mode Network Dysfunction in Persons at Risk of Alzheimer's Disease With Non-invasive Techniques
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DEVICE: real-rTMS|DEVICE: sham-rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase I, Multicenter, Randomized Trial to Evaluate the Safety and Immunogenicity of a Recombinant Vaccinia-HIV Envelope Vaccine (HIVAC-1e) in Combination With a Panel of Subunit Recombinant HIV Envelope Vaccines
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: rgp120/HIV-1 SF-2|BIOLOGICAL: Env 2-3|BIOLOGICAL: HIVAC-1e|BIOLOGICAL: gp160 Vaccine (MicroGeneSys)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of BV With Tislelizumab for the Treatment of CD30+ Relapsed/Refractory NK/T-cell Lymphoma
Status: NOT_YET_RECRUITING
Conditions: NK/T Cell Lymphoma Nos
Interventions: DRUG: Brentuximab Vedotin in Combination with Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Patterns and Health Outcomes (Cardiovascular, Metabolic, Endocrine, Neurological, Skeletal Muscular, Cancer)
Status: COMPLETED
Conditions: Cardiovascular Diseases|Cerebrovascular Disorders|Metabolic Disease|Neoplasms|Endocrine System Diseases|Neurologic Symptoms|Skeletal Anomalies|Diabetes Mellitus|Pregnancy Complications
Interventions: OTHER: Dietary intake
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Lenalidomide/Dexamethasone With Nivolumab and Ipilimumab in Patients With Newly Diagnosed Multiple Myeloma
Status: WITHDRAWN
Conditions: Malignant Neoplasms Stated as Primary Lymphoid Haematopoietic|Multiple Myeloma
Interventions: DRUG: Nivolumab|DRUG: Lenalidomide|DRUG: Dexamethasone|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety/Efficacy Study of 2nd Cycle Treatment After 6 Months of 1st Cycle HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell Treatment in ALS
Status: UNKNOWN
Conditions: Amyotrophic Lateral Sclerosis
Interventions: BIOLOGICAL: HYNRCS-Allo inj
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using a Patient-Centered mHealth Intervention to Improve Adherence to Oral Anticancer Medications
Status: COMPLETED
Conditions: Sarcoma|Lung|Solid Tumor Gastrointestinal
Interventions: OTHER: SMS/MMS text messaging|OTHER: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety Study of Ingavirin® to Treat Influenza and Acute Respiratory Viral Infections in Patients 13-17 y.o.
Status: COMPLETED
Conditions: Influenza, Human|Acute Respiratory Infection|Viral Infection|Common Cold
Interventions: DRUG: Ingavirin|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial of CRLX101 in Treatment of Patients With Advanced or Metastatic Stomach, Gastroesophageal, or Esophageal Cancer That Cannot be Removed by Surgery
Status: COMPLETED
Conditions: Adenocarcinoma of the Esophagus|Adenocarcinoma of the Gastroesophageal Junction|Diffuse Adenocarcinoma of the Stomach|Intestinal Adenocarcinoma of the Stomach|Mixed Adenocarcinoma of the Stomach|Recurrent Esophageal Cancer|Recurrent Gastric Cancer|Squamous Cell Carcinoma of the Esophagus|Stage IIIB Esophageal Cancer|Stage IIIB Gastric Cancer|Stage IIIC Esophageal Cancer|Stage IIIC Gastric Cancer|Stage IV Esophageal Cancer|Stage IV Gastric Cancer
Interventions: DRUG: cyclodextrin-based polymer-camptothecin CRLX101|OTHER: Laboratory biomarker analysis|OTHER: Pharmacological studies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impaired Vigilance, and Its Effects on Cognition and Behavior
Status: COMPLETED
Conditions: Sleep Deprivation|Feeding Behavior
Interventions: BEHAVIORAL: Time in bed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Brain Irradiation in Treating Patients With Limited-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: RADIATION: Prophylactic cranial irradiation, 2.5 Gy fx|RADIATION: Prophylactic cranial irradiation, 2.0 Gy fx|RADIATION: Prophylactic cranial irradiation, 1.5 Gy fx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hybrid Versus Non-Hybrid Endoscopic Submucosal Dissection for Colorectal Polyps (SHORT-ESD)
Status: RECRUITING
Conditions: Colorectal Lesions
Interventions: PROCEDURE: Hybrid ESD|PROCEDURE: Non-hybrid ESD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: L-Arginine and Antioxidant Vitamins During Pregnancy to Reduce Preeclampsia
Status: TERMINATED
Conditions: Pre-Eclampsia
Interventions: PROCEDURE: L-arginine supplementation in a medical food|PROCEDURE: Vitamin C and E supplementation in a medical food
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Oral Enteral Nutrition Tube Feeding on Stroke Survivors
Status: NOT_YET_RECRUITING
Conditions: Cerebrovascular Accident
Interventions: DEVICE: Intermittent Oro-esophageal Tube Feeding|DEVICE: Nasogastric Tube Feeding|BEHAVIORAL: comprehensive rehabilitation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of Two Marketed Multi-Purpose Solutions for Silicone Hydrogel Contact Lenses - Study 2
Status: COMPLETED
Conditions: Myopia|Hyperopia|Contact Lens Comfort
Interventions: DEVICE: Opti-Free® PureMoist® MPDS|DEVICE: RevitaLens MPDS|DEVICE: Habitual Contact Lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Low-Level Laser Therapy on Mouth Opening and Surface Electromyography in Temporomandibular Disorders
Status: RECRUITING
Conditions: Temporomandibular Joint Dysfunction Syndrome|Pain, Face
Interventions: OTHER: Low level laser|DEVICE: Soft occlusive splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Perineural Dexmedetomidine on the ED50 Ropivacaine for Brachial Plexus Blocks in Pediatric Patients: a Randomized Trial
Status: UNKNOWN
Conditions: Dose-Response Relationship, Drug
Interventions: DRUG: perineural dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Oesophageal Protection During AF Ablation
Status: UNKNOWN
Conditions: Esophageal Diseases
Interventions: DEVICE: esophageal cooling device (Attune Medical, Chicago, IL)|OTHER: Standard esophageal temperature probe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Willkommen Mutterglück: Online CBT for Pregnant and Postpartum Women With Depression and Anxiety
Status: UNKNOWN
Conditions: Prenatal Anxiety|Generalized Anxiety|Postpartum Depression|Major Depressive Disorder
Interventions: BEHAVIORAL: Online Cognitive Behavioural Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abemaciclib (LY2835219) in Patients With Recurrent Primary Brain Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Brain Tumor
Interventions: DRUG: abemaciclib|DRUG: abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Allogeneic Human Adipose Derived Stem Cell Component Extract on Androgenic Alopecia
Status: COMPLETED
Conditions: Androgenic Alopecia
Interventions: OTHER: stem cell component extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Metricath Gemini System, a Device Intended to Make Arterial Measurements and Perform Angioplasty Dilations.
Status: COMPLETED
Conditions: Angioplasty
Interventions: DEVICE: Metricath Gemini System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Birinapant With 5-azacitidine in MDS Subjects Who Are Naïve, Have Relapsed or Are Refractory to 5-azacitidine Therapy
Status: COMPLETED
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: Birinapant|DRUG: 5-Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Helping Women Stay Up-To-Date With Cancer Screening By Using a Prevention Care Manager or Usual Care
Status: COMPLETED
Conditions: Breast Cancer|Cervical Cancer|Colorectal Cancer
Interventions: BEHAVIORAL: Prevention Care Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: MejoraCare-Paraguay: mHealth Solution for Chronic Patients During the COVID-19 Outbreak in Paraguay
Status: COMPLETED
Conditions: Quality of Life|Stress|Emotional Adjustment
Interventions: DEVICE: MejoraCare
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate Changes in Limb Fat When Switching From a Thymidine Analogue
Status: COMPLETED
Conditions: Lipodystrophy
Interventions: DRUG: tenofovir DF|DRUG: abacavir 300mg twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: N-acetyl Cysteine and Clomiphene Citrate or Metformin and Clomiphene Citrate for Women With CC Resistant Polycystic Ovary Syndrome (PCOS).
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: combined N-acetyl cysteine -CC|DRUG: combined metformin-CC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in Participants With Early-Stage or Locally Advanced Human Epidermal Growth Factor Receptor (HER) 2-Positive and Estrogen Receptor/Progesterone Receptor Negative Breast Cancer to Evaluate the Efficiency and Safety of Treatment With Trastuzumab Plus (+) QL1209/Pertuzumab + Docetaxel.
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab|DRUG: QL1209|DRUG: Pertuzumab|DRUG: Docetaxel|PROCEDURE: surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-label Extension Study in Patients 65 Years or Older With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Post-Chlorambucil Therapy Follow-up|DRUG: Ibrutinib|DRUG: Second-line Ibrutinib|DRUG: Alternative Anticancer Treatment|DRUG: Alternative Anti-cancer Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Clinical Study of the Safety and Efficacy of Istaroxime in Treatment of Acute Decompensated Heart Failure
Status: COMPLETED
Conditions: Acute Decompensated Heart Failure
Interventions: DRUG: Placebo|DRUG: Istaroxime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Elemene Plus Stupp Protocol Versus Stupp Protocol Alone for Newly-diagnosed Glioblastoma
Status: NOT_YET_RECRUITING
Conditions: Glioblastoma, IDH-wildtype
Interventions: DRUG: Elemene|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modulation of Cognition and Brain Connectivity by Noninvasive Brain Stimulation in Patients With Mild Cognitive Impairment Due to Alzheimer's Disease
Status: UNKNOWN
Conditions: Mild Cognitive Impairment
Interventions: DEVICE: Transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A 6-Month Consumer Behavior Study of a Self-Management System (0803-084)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: MK0803, lovastatin|BEHAVIORAL: Self-Management System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Two-Week Crossover Dispensing Evaluation Of Orion Daily Wear Soft Contact Lens
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Orion daily disposable contact lens|DEVICE: Gemini daily disposable contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Tolerability DDI Short Course Treatment of LTBI Infection With High-dose Rifapentine and Isoniazid or Standard Isoniazid Preventive Therapy in HIV+ Patients (DOLPHIN & DOLPHIN TOO)
Status: COMPLETED
Conditions: Respiratory Tract Infections|HIV Infections
Interventions: COMBINATION_PRODUCT: 3HP plus DTG +2NRTIs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Colostomy Closure Without Mechanical Bowel Preparation Safe in Pediatric Patients? Randomized Clinical Trial.
Status: UNKNOWN
Conditions: Colostomy|Surgical Anastomosis
Interventions: DRUG: No Mechanical Bowel Preparation|DRUG: Mechanical Bowel Preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Predictive and Prognostic Biomarkers in Patients With Mycosis Fungoides and Sézary Syndrome.
Status: RECRUITING
Conditions: Mycosis Fungoides|Sezary Syndrome
Interventions: DIAGNOSTIC_TEST: Blood tests and testing of analysis of the lymphoma microenvironment in skin, skin barrier and skin microbiology profile.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Local Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: A Multicenter Randomized, Controlled Trial (VANCO)
Status: COMPLETED
Conditions: Post Operative Surgical Site Infection
Interventions: DRUG: Vancomycin antibiotic powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Immunogenicity After Receipt of JE Vaccine and Antibody Response and Safety to a Booster Dose
Status: COMPLETED
Conditions: Encephalitis, Japanese
Interventions: BIOLOGICAL: Live Attenuated Japanese Encephalitis SA-14-14-2 Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Escitalopram for Agitation in Alzheimer's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Dementia
Interventions: DRUG: Escitalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Essential Fatty Acids During Complementary Feeding
Status: COMPLETED
Conditions: Obesity|Growth|Metabolic Syndrome|Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: Fish Oil|DIETARY_SUPPLEMENT: Sunflower Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study in Adults of AZD1222 and rAd26-S Administered as Heterologous Prime-Boost Regimen for the Prevention of COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: AZD1222|BIOLOGICAL: rAd26-S
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Diaphragmatic Atrophy Related to Mechanical Ventilation
Status: COMPLETED
Conditions: Septic Shock|Acute Respiratory Distress
Interventions: DEVICE: Ultrasound|DEVICE: Ultrasound|OTHER: Neuromyopathy score|OTHER: Respiratory performances
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: An HIV Intervention for Black Men at Risk - The Enhanced Sexual Health Intervention for Men (ES-HIM)
Status: COMPLETED
Conditions: HIV|Depression|Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Enhanced Sexual Health Intervention for Men (ES-HIM)|BEHAVIORAL: Health Promotion (HP) Comparison Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pre- Versus Sub-pectoral Implant-based Breast Reconstruction After Skin-sparing Mastectomy or Nipple-sparing Mastectomy OPBC-02PREPEC
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Reconstruction|Implant-Based Breast Reconstruction (IBBR)
Interventions: PROCEDURE: pre-pectoral IBBR|PROCEDURE: sub-pectoral IBBR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Interleukin-12 in Treating Patients With Cancer in the Abdomen
Status: COMPLETED
Conditions: Anal Cancer|Colorectal Cancer|Gallbladder Cancer|Gastric Cancer|Pancreatic Cancer
Interventions: BIOLOGICAL: Recombinant Interleukin-12
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Comparison of Effects Between Increased Dose of Clopidogrel and Addition of Cilostazol
Status: COMPLETED
Conditions: Clopidogrel Non-Responsiveness
Interventions: DRUG: aspirin, clopidogrel|DRUG: aspirin, clopidogrel, cilostazol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab in Combination With Visudyne Photodynamic Therapy (PDT)
Status: COMPLETED
Conditions: Age Related Macular Degeneration|Choroidal Neovascularization|Macular Edema
Interventions: DRUG: Bevacizumab|DEVICE: verteporfin photodynamic therapy reduced fluence|DEVICE: verteporfin photodynamic therapy standardfluence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serratus Anterior Plane Block Versus Paravertebral Block for Postmastectomy Analgesia
Status: WITHDRAWN
Conditions: Breast Cancer|Acute Pain
Interventions: PROCEDURE: Serratus Anterior Muscle Plane block (SAM block)|PROCEDURE: Paravertebral Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Sickle Cell Disease (SCD)
Interventions: DRUG: Crizanlizumab (SEG101)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing Loss of Independence Through Exercise (PLIÉ) in Persons With Mild Cognitive Impairment (MCI)
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Behavioral: Preventing Loss of Independence through Exercise (PLIE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acute Dose-ranging Effects of Mango Leaf Extract (Zynamite® 15%) on Cognitive Function and Cerebral Blood Flow
Status: COMPLETED
Conditions: Cognitive Change
Interventions: DIETARY_SUPPLEMENT: Zynamite® 15% 150mg|DIETARY_SUPPLEMENT: Zynamite® 15% 300mg|DIETARY_SUPPLEMENT: Zynamite® 15% 600mg|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Phase 2 Study to Evaluate the Safety and Efficacy of VX-135 With Ribavirin in Treatment-Naïve Subjects With Chronic Hepatitis C
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: VX-135|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diabetes Prevention - Immune Tolerance
Status: COMPLETED
Conditions: Prediabetes|Type 1 Diabetes
Interventions: OTHER: Placebo comparator|DRUG: Diamyd
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Neuromuscular Electrical Stimulation as an Adjunct to Exercise Training in Stable Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: OTHER: Neuromuscular electrical stimulation|OTHER: Endurance training|OTHER: Quadriceps strength training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety and Efficacy of Momelotinib in Subjects With Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis, Polycythemia Vera or Essential Thrombocythemia
Status: COMPLETED
Conditions: Primary Myelofibrosis|Post-Polycythemia Vera Myelofibrosis|Post-Essential Thrombocythemia Myelofibrosis|Polycythemia Vera|Essential Thrombocythemia
Interventions: DRUG: Momelotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HAIC Versus Systemic Chemotherapy for Unresectable ICC
Status: UNKNOWN
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: DRUG: irinotecan, oxaliplatin , fluorouracil, and leucovorin|DRUG: gemcitabine and oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label, Two-period, Fixed-sequence Study to Evaluate Multiple-dose Itraconazole Effect on The Single-dose PK of PF-06372865 in Healthy Subjects
Status: WITHDRAWN
Conditions: Healthy
Interventions: DRUG: PF-06372865|DRUG: itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Pindolol Augmentation in Venlafaxine Treated Patients With Major Depression
Status: TERMINATED
Conditions: Major Depression
Interventions: DRUG: Pindolol and venlafaxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Safety, Efficacy, and Pharmacokinetics of INM004 in Pediatric Patients With STEC-HUS
Status: COMPLETED
Conditions: Diarrhea-Associated Hemolytic Uremic Syndrome|Pediatric Kidney Disease|Hemolytic-Uremic Syndrome
Interventions: DRUG: INM004|OTHER: SoC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of a Single Oral Dose of BI 1026706 in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1026706|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Study With GLPG4716 and Nintedanib and Pirfenidone in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pirfenidone|DRUG: GLPG4716|DRUG: Nintedanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of tES on a Cognitive Training
Status: COMPLETED
Conditions: Memory Impairment
Interventions: DEVICE: real anodal tDCS healthy elderly|DEVICE: real tACS healthy elderly|DEVICE: sham tES healthy elderly|DEVICE: real anodal tDCS MCI|DEVICE: real tACS MCI|DEVICE: sham tES MCI|DEVICE: real anodal tDCS AD|DEVICE: real tACS AD|DEVICE: sham tES AD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE