pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Tolerability of SYNB1618 in Healthy Adult Volunteers and Adult Subjects With Phenylketonuria
Status: COMPLETED
Conditions: Phenylketonuria|Healthy
Interventions: DRUG: SYNB1618|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of SI-B003 and BL-B01D1+SI-B003 in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer, Nasopharyngeal Carcinoma and Other Solid Tumors
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer|Nasopharyngeal Carcinoma
Interventions: DRUG: BL-B01D1|DRUG: SI-B003
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ANX-188 Thorough QT/QTc Study in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ANX-188 Therapeutic Dose|DRUG: ANX-188 Supratherapeutic dose|DRUG: Saline|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Blueberries, Inflammation, Motivation, and Physical Activity
Status: ACTIVE_NOT_RECRUITING
Conditions: Depressive Symptoms
Interventions: OTHER: Freeze-dried Blueberry Powder|OTHER: Placebo Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Response of Gut Microbiota in Type 2 Diabetes to Hypoglycemic Agents
Status: UNKNOWN
Conditions: Type2 Diabetes Mellitus
Interventions: DRUG: Glucophage 500Mg Tablet|DRUG: Acarbose Tablets|DRUG: Sitagliptin tablet|DRUG: Dapagliflozin Tablet|DRUG: Pioglitazone Tablets|DRUG: Glimepiride Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ABT-072 in Healthy and Hepatitis C Virus Genotype 1-Infected Adults
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: ABT-072|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Randomized Control Trial: Synchronized Non-invasive Positive Pressure Ventilation Versus Non Synchronized Non Invasive Positive Pressure Ventilation in Extremely Low Birth Weight Infants
Status: COMPLETED
Conditions: BPD - Bronchopulmonary Dysplasia
Interventions: DEVICE: NAVA technology to synchronize NIPPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Border Zone Stereotactic Radiosurgery With Bevacizumab in Patients With Glioblastoma Multiforme
Status: COMPLETED
Conditions: Glioblastoma Multiforme|Glioblastoma - Category
Interventions: DRUG: Bevacizumab|PROCEDURE: Magnetic Resonance Spectroscopy (MRS)|PROCEDURE: Border Zone Stereotactic Radiosurgery (BZ-SRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of ACE-031 in Healthy Postmenopausal Women
Status: COMPLETED
Conditions: Muscular Atrophy
Interventions: BIOLOGICAL: ACE-031|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3, Multicenter, Randomized, Open-Label Study to Compare the Efficacy and Safety of Pomalidomide in Combination With Low-Dose Dexamethasone Versus High-Dose Dexamethasone in Subjects With Refractory Multiple Myeloma or Relapsed and Refractory Multiple Myeloma and Companion Study
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impaired Immunity in Patients With Cancer: Influence of Cancer Stage, Chemotherapy, and Cytomegalovirus Infection
Status: UNKNOWN
Conditions: Neoplasms
Interventions: OTHER: Immune profiling and DC vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Incidence of TNS After Intrathecal Lidocaine v.s Bupivacaine
Status: UNKNOWN
Conditions: Orthopedic Disorder|Leg Injuries
Interventions: DRUG: Lidocaine|DRUG: Bupivacaine Hcl 0.5% Inj_#2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EP Intravenous Anesthesia in Hysteroscopy
Status: RECRUITING
Conditions: Anesthesia
Interventions: DRUG: Sedation Etomidate combined with propofol|DRUG: Sedation Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Radiofrequency Ablation for Anal Intraepithelial Neoplasia Using the HALO Ablation System
Status: COMPLETED
Conditions: HIV-negative Subjects With Intra-anal Intraepithelial Neoplasia Containing High-Grade Squamous Intraepithelial Lesions
Interventions: DEVICE: Radiofrequency Ablation (RFA) using the HALO Ablation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Marinobufagenin as a Target for DIGIBIND in Hypertensive Patients With End-stage Renal Disease
Status: UNKNOWN
Conditions: Hypertension|Hemodialysis
Interventions: DRUG: Digoxin immune fab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Buprenorphine on Mood in Adults With a Range of Depressive Symptomatology
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: 0.2mg Buprenorphine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Negative Pressure Wound Therapy in the Treatment of DFUs Incl. Post Amputation Wounds.
Status: COMPLETED
Conditions: Diabetes|Foot Ulcers
Interventions: PROCEDURE: NPWT System|DEVICE: NPWT system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Benefit of Autologous Blood Transfusion in Total Hip Arthroplasty
Status: COMPLETED
Conditions: Transfusion|Hip Arthroplasty
Interventions: PROCEDURE: Preoperative autologous blood donation, 14 days before surgery|PROCEDURE: Preoperative autologous blood donation, 72 hours before surgery|PROCEDURE: Without preoperative blood donation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Correlation Study of Vascular Parameters in Hypertensive Men With Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction|Arterial Hypertension|Endothelial Dysfunction
Interventions: DRUG: Vardenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Erlotinib and Bevacizumab in Treating Patients With Stage IV Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: bevacizumab|DRUG: erlotinib hydrochloride|GENETIC: fluorescence in situ hybridization|GENETIC: gene expression analysis|OTHER: immunologic technique|OTHER: laboratory biomarker analysis|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Kangaroo Care on Parents' Perceived Parenting Self-Efficacy, Infant Attachment and Newborn Vital Signs
Status: RECRUITING
Conditions: Kangaroo Care|Fathers|Mother-Infant Interaction|Premature Infant
Interventions: OTHER: Kangaroo care practice by both mother and father|OTHER: Kangaroo care practice only mother
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Different Treatment Modalities for Atrophied Distal Extension Maxillary Ridges
Status: UNKNOWN
Conditions: Partial Edentulism Class 1
Interventions: PROCEDURE: Long implant and partial overdentures|PROCEDURE: Sinus lift and long implant|PROCEDURE: short implant without sinus lift|DEVICE: Partial overdentures|DEVICE: Metal ceramic prosthesis on long implants|DEVICE: Metal ceramic prosthesis on short implants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COronary Re-engageMent aFter randOm NavitoR alignmenT (COMFORT STUDY)
Status: RECRUITING
Conditions: Aortic Valve Stenosis|Transcatheter Aortic Valve Replacement
Interventions: PROCEDURE: TAVR Aligned|PROCEDURE: TAVR Random
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CD19 CAR T Cells in Patients With Resistant or Refractory CD19+ Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia, Adult B-Cell|Acute Lymphoblastic Leukaemia Recurrent
Interventions: BIOLOGICAL: CD19 CAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minocycline in Clinically Isolated Syndromes (CIS)
Status: COMPLETED
Conditions: Clinically Isolated Syndromes|Early Single Relapse of Multiple Sclerosis
Interventions: DRUG: Minocycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Evaluation of the Effect of the AmnioFix Amniotic Membrane Allograft in Patients Undergoing Posterior Instrumentation Removal
Status: COMPLETED
Conditions: Adhesions of Soft Tissue
Interventions: OTHER: Scheduled removal of posterior instrumentation with AmnioFix|OTHER: Scheduled removal of posterior instrumentation without AmnioFix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S-flurbiprofen Bioavailability Trial to Compare a Newly Developed Patch vs. a Marketed Tablet
Status: COMPLETED
Conditions: Comparative Bioavailability
Interventions: DRUG: Esflurbiprofen hydrogel patch 165 mg (EFHP)|DRUG: Froben 100 mg comprimidos revestidos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neuromuscular Electrical Stimulation for Intensive Care Unit-acquired Weakness Assessment
Status: UNKNOWN
Conditions: Polyneuropathy, Critical Illness
Interventions: DEVICE: Neuromuscular electrical stimulation|DEVICE: Sham control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diabetes Mellitus and microRNA as Risk Factors for Mild Cognitive Impairment: Impact of Life Style Modification
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Health education program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Correlation Between Visual Field Defects on Foresee Preferential Hyperacuity Perimeter(PHP) and on Optical Coherence Tomography (OCT) in Patients With Choroidal Neovascularization (CNV)
Status: COMPLETED
Conditions: Age Related Macular Degeneration
Interventions: DEVICE: PHP - Preferential Hyperacuity Perimeter (Foresee)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hispanic Men Building Respect Education and Safety/ HoMBRES Manteniendo Respeto, Educacion y Seguridad.
Status: COMPLETED
Conditions: Substance Abuse|Domestic Violence|HIV/AIDS
Interventions: BEHAVIORAL: HoMBReS intervention|BEHAVIORAL: Families Talking Together (FTT)|BEHAVIORAL: Diabetes Prevention Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Durvalumab With Carboplatin and Etoposide Chemotherapy in Pulmonary Large-cell Neuroendocrine Carcinoma (LCNEC)
Status: RECRUITING
Conditions: Pulmonary Large-cell Neuroendocrine Carcinoma
Interventions: DRUG: Durvalumab 50 MG/1 ML Intravenous Solution [IMFINZI]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inositol Hexaphosphate: A Novel Treatment Strategy for Bipolar Disorder?
Status: COMPLETED
Conditions: Bipolar Disorder|Manic Depression
Interventions: DRUG: IP6|DRUG: Lamotrigine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Versus Palpation Guided Cricothyrotomy With Poorly Defined Anatomical Landmarks
Status: COMPLETED
Conditions: Airway Management
Interventions: PROCEDURE: Utrasound guided cricothyrotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Continuous Positive Airway Pressure (CPAP) in Patients With Acute Coronary Syndrome and Obstructive Sleep Apnea (OSA)
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Obstructive Sleep Apnea
Interventions: OTHER: Standard care|DEVICE: continuous positive airway pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Flucelvax (TIVc or QIVc) Pregnancy Registry
Status: COMPLETED
Conditions: Influenza, Human|Pregnancy|Birth Defect
Interventions: BIOLOGICAL: Flucelvax Trivalent Influenza Vaccine|BIOLOGICAL: Flucelvax Quadrivalent Influenza Vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Somatropin in Adult Patients With Isolated Growth Hormone Deficiency
Status: TERMINATED
Conditions: Growth Hormone Deficiency
Interventions: DRUG: Placebo|DRUG: Somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Correlations Between Different Walk Tests in Patients With Transfemoral Amputees
Status: UNKNOWN
Conditions: Amputation|Lower Extremity
Interventions: OTHER: Evaluation of the correlation between walking speed in the 6MWT and in 2MWT, and the walking speed observed in the continuous 2km walk test and in the 10 meters walk test.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: Safety of Umbilical Cord Mesenchymal Stem Cell Local Intramuscular Injection for Treatment of Uterine Scars
Status: WITHDRAWN
Conditions: Uterine Scar
Interventions: OTHER: Umbilical cord MSCs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-op vs Pre-op Transbronchial Localization for Small Lung Nodule
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: PROCEDURE: AF-guided endobronchial marking|DEVICE: ENB-guided endobronchial marking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Technological Balance and Gait Rehabilitation in Patients With Stroke Sequelae: Functional, Motor and Cognitive Outcomes
Status: COMPLETED
Conditions: Stroke|Gait Disorders, Neurologic|Balance
Interventions: DEVICE: Technological Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of an Oral Nutritional Supplement Rich in Omega-3 Fatty Acids on Functional State and Quality of Life in Malnourished Patients With Gastroenterological Tumors
Status: COMPLETED
Conditions: Colorectal Neoplasms|Hepatocellular Carcinoma|Cholangiocarcinoma
Interventions: DRUG: oral nutritional supplement rich in eicosapentanoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concerta in the Treatment of ADHD in Youth and Adults With Bipolar Disorder
Status: COMPLETED
Conditions: ADHD|Bipolar Disorder
Interventions: DRUG: methylphenidate HCl (Concerta)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate And Cyclophosphamide In Metronomic Administration: Dose Escalation Study Of Imatinib Mesylate
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Imatinib mesylate, Cyclophosphamide (Dosing level 1 )|DRUG: Imatinib mesylate, Cyclophosphamide (Dosing level 2)|DRUG: Imatinib mesylate, Cyclophosphamide (Dosing level 3)|PROCEDURE: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Silymarin on the Prevention of Hepatotoxicity From Antituberculosis Drugs
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: silymarin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Evaluate The Safety and Efficacy of 'AVI' Stent Comparing With Firebird2® For Treating Coronary Revascularization
Status: UNKNOWN
Conditions: Ischemic Heart Disease|Myocardial Ischemia|Coronary Disease|Acute Coronary Syndrome
Interventions: DEVICE: AVI® Arsenic trioxide drug eluting stent delivery system|DEVICE: Firebird2® sirolimus eluting stent system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Open-Label Dose-Escalation Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Efficacy of Intracerebroventricular BMN 190 in Patients With Late-Infantile Neuronal Ceroid Lipofuscinosis (CLN2) Disease
Status: COMPLETED
Conditions: Jansky-Bielschowsky Disease|Batten Disease|Late-Infantile Neuronal Ceroid Lipofuscinosis Type 2|CLN2 Disease
Interventions: BIOLOGICAL: BMN 190
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of the Inhibitors of Tyrosine Kinase on the Male Fertility
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia|Gastrointestinal Stromal Tumors
Interventions: DRUG: Imatinib treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study on the Use of a Sensory Panel to Assess Comfort Between Three Different Contact Lenses
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DEVICE: balafilcon A (8.6)|DEVICE: balafilcon A (8.3)|DEVICE: senofilcon A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Impact of RIVP on GI Function in Patients Undergoing Surgical Repair for ATAAD
Status: RECRUITING
Conditions: Type A Aortic Dissection
Interventions: PROCEDURE: Retrograde Inferior Vena Cava Perfusion|PROCEDURE: Antegrade cerebral perfusion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Recurrence Rate Comparison Between Esomeprazole and Lansoprazole in Eradicating Helicobacter Pylori Infection Among Children
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Esomeprazole|DRUG: Lansoprazole|DRUG: Amoxicillin|DRUG: Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Study of Capecitabine and Erlotinib Concurrent With Radiotherapy for Non-Operable Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Capecitabine, Tarceva
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Alcohol Misuse and Consequences in Vulnerable Women
Status: UNKNOWN
Conditions: Alcohol Drinking
Interventions: BEHAVIORAL: Behavioral: Motivational Interview (MI)|BEHAVIORAL: Behavioral: Health Coaching (HC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dexmedetomidine Versus Dexmedetomidine With Ketamine in Mechanically Ventilated ARDS Patients
Status: RECRUITING
Conditions: Haemodynamic Instability
Interventions: DRUG: dexmedetomidine plus ketamine|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of MK-8527 in Healthy Lactating Female Participants (MK-8527-009)
Status: NOT_YET_RECRUITING
Conditions: Healthy|HIV Pre-exposure Prophylaxis
Interventions: DRUG: MK-8527
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neurofeedback Training (NFT) on Sleep Quality and Cognitive Function Performance Among HIV-infected Persons
Status: ENROLLING_BY_INVITATION
Conditions: Poor Quality Sleep|HIV Infections
Interventions: DEVICE: Neurofeedback|DEVICE: Shame neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RO4929097 in Treating Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Recurrent Colon Cancer|Recurrent Rectal Cancer|Stage IV Colon Cancer|Stage IV Rectal Cancer
Interventions: DRUG: gamma-secretase/Notch signalling pathway inhibitor RO4929097|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liquid Biopsy Based NGS in Newly Diagnosed NSCLC
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer Metastatic|Newly Diagnosed NSCLC|Non-Squamous Non-Small Cell Neoplasm of Lung
Interventions: BEHAVIORAL: iNUDGE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Antibody and Delayed Cyclosporine Versus Initial Cyclosporine Alone in Patients Receiving Kidney Transplants
Status: COMPLETED
Conditions: Kidney Transplantation|Chronic Allograft Nephropathy
Interventions: BIOLOGICAL: Cyclosporine|BIOLOGICAL: Anti-human thymocyte globulin (rabbit)|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of SMS Reminders of Blood Pressure-lowering Drugs Intake
Status: COMPLETED
Conditions: Hypertension|Primary Hypertension|Non-Adherence, Medication|Non-Adherence, Patient
Interventions: BEHAVIORAL: SMS reminders of medicines intake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Oral THC and CBD in Men and Women
Status: NOT_YET_RECRUITING
Conditions: Drug Abuse|Intoxication by Drug|Impairment
Interventions: DRUG: Placebo|DRUG: THC|DRUG: CBD|DRUG: THC + CBD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 1 Trial of OPA-15406 Ointment in Healthy Adult Male Subjects
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: 0.3% OPA-15406 Ointment|DRUG: 1% OPA-15406 Ointment|DRUG: 3% OPA-15406 Ointment|DRUG: Placebo Ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nalbuphine and Flurbiprofen for Oculoplastic Surgery
Status: COMPLETED
Conditions: Surgery|Anesthesia|Pain
Interventions: DRUG: Nalbuphine|DRUG: Flurbiprofen Axetil|DRUG: Nalbuphine and Flurbiprofen Axetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Normobaric Hyperoxia Combined With Intravenous Thrombolysis for Acute Ischemic Stroke (OPENS-3)
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: PROCEDURE: Normobaric Hyperoxia|PROCEDURE: Nasal oxygen|DRUG: Intravenous thrombolysis(rt-PA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Hospitalisation Times and Mortality According to Drug Dose in Patients Given Systemic Methylprednisolone With a Pre-diagnosis of Covid-19 Pneumonia; Retrospective Study
Status: COMPLETED
Conditions: COVID-19|Methylprednisolone|Pneumonia
Interventions: DRUG: methylprednisolone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Herceptin (Trastuzumab) in Combination With 2nd-Line Chemotherapy in Patients With HER2 Positive Metastatic Breast Cancer.
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Second line chemotherapy|DRUG: trastuzumab [Herceptin]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Cerebrolysin and Amantadine Sulfate Administration for Patients With Traumatic Brain Injury in the ICU
Status: RECRUITING
Conditions: Traumatic Brain Injury
Interventions: DRUG: Cerebrolysin|DRUG: amantadine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of the Pancreatic Stump With Neoprene®-Based Glue After High-risk Pancreatoduodenectomy
Status: COMPLETED
Conditions: Pancreatic Fistula|Pancreatic Neoplasms|Postoperative Complications
Interventions: PROCEDURE: Pancreatic duct occlusion with Neoprene|PROCEDURE: Pancreato-Jejunal anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Single-blind, Parallel Group and Multiple - Dose Design Study
Status: COMPLETED
Conditions: Acetaminophen Toxicity
Interventions: DRUG: Panadol®|DRUG: SafeTynadol®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Efficacy of Acupuncture Combined With Moving Cupping and Ear Point Tapping for Moderate and Severe Acne Vulgaris
Status: UNKNOWN
Conditions: Acne Vulgaris
Interventions: PROCEDURE: 3 times per week therapeutic frequency|PROCEDURE: 1 time per week therapeutic frequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Total Parathyroidectomy With and Without Autotransplantation
Status: UNKNOWN
Conditions: Secondary Hyperparathyroidism
Interventions: PROCEDURE: total PTX without autotransplantation|PROCEDURE: total PTX with autotransplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab (MK-3475) in Previously-Treated Participants With Advanced Carcinoma of the Esophagus or Esophagogastric Junction (MK-3475-180/KEYNOTE-180)
Status: COMPLETED
Conditions: Esophageal Carcinoma|Esophagogastric Junction Carcinoma
Interventions: BIOLOGICAL: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Screening to Prophylax Against Clostridium Difficile Infection -
Status: COMPLETED
Conditions: Clostridium Difficile Infection
Interventions: DRUG: Vancomycin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Short-term Portable Air Purifier Use on Occupant Health Indicators
Status: COMPLETED
Conditions: Non-smoking, Healthy Adults
Interventions: DEVICE: True-Washout-Sham Air Filtration Intervention|DEVICE: Sham-Washout-True Air Filtration Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacist Led Intervention to Improve Medication Use in Older In-patients Living With Frailty: the Drug Burden Index
Status: ACTIVE_NOT_RECRUITING
Conditions: Sedative Adverse Reaction|Anticholinergic Adverse Reaction
Interventions: OTHER: Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Chemotherapy With Liposomal Cytarabine CNS Prophylaxis for Adult Acute Lymphoblastic Leukemia & Lymphoblastic Lymphoma
Status: TERMINATED
Conditions: Acute Lymphocytic Leukemia|Adult Lymphoblastic Lymphoma
Interventions: DRUG: DNR|DRUG: VCR|DRUG: PEG-asp|DRUG: CTX|DRUG: Prednisone|DRUG: Liposomal AraC|DRUG: MTX|DRUG: LCV|DRUG: AraC|DRUG: Etoposide|DRUG: Dasatinib|DRUG: Rituximab|DRUG: Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PD-1 Antibody Following Preoperative Chemoradiotherapy for Locally Advanced pMMR/MSS Rectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Carcinoma
Interventions: DRUG: PD-1 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation in Real Life of TLC-NOSF Dressings in the Local Treatment of Chronic Wounds (DFU and VLU)
Status: RECRUITING
Conditions: Real Life Study|TLC-NOSF Dressings|Venous Leg Ulcer|Diabetic Foot Ulcer|QoL Questionnaire
Interventions: DEVICE: TLC-NOSF dressings (D'URGOSTART PLUS® BORDER, URGOSTART PLUS® PAD and URGOSTART INTERFACE®)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study in Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: LY2189265|DRUG: Exenatide|DRUG: Placebo|DRUG: Metformin|DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clopidogrel Versus Ticagrelor in Type-2 Diabetes
Status: COMPLETED
Conditions: Coronary Artery Disease|Diabetes Mellitus
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel|DRUG: Standard medical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega 3, Leucine, Probiotic Lactobacillus Paracasei PS23 on Muscle Mass in Sarcopenic Subjects
Status: UNKNOWN
Conditions: Sarcopenia|Elderly|Omega 3
Interventions: DIETARY_SUPPLEMENT: OLEP|COMBINATION_PRODUCT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise Training on Brain Insulin Responsiveness
Status: RECRUITING
Conditions: Insulin Resistance|Obesity
Interventions: BEHAVIORAL: single bout of moderate intensity continuous training (MICT)|BEHAVIORAL: single bout of High Intensity Interval Training (HIIT)|BEHAVIORAL: waiting control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison Sacral Erector Spinae Block Versus Caudal Block
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Ultrasound Guided Caudal Block|PROCEDURE: Sacral Erector Spinae Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Thermomechanical Stimulation Device and Virtual Reality Glasses During Peripheral Intravenous Catheterization
Status: COMPLETED
Conditions: Catheterization
Interventions: OTHER: Virtual Reality Glasses|OTHER: Thermomechanical Stimulation Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RO4929097 in Treating Patients With Stage IIIB, Stage IIIC, or Stage IV Melanoma That Can Be Removed by Surgery
Status: WITHDRAWN
Conditions: Stage IIIB Melanoma|Stage IIIC Melanoma|Stage IV Melanoma
Interventions: DRUG: gamma-secretase/Notch signalling pathway inhibitor RO4929097|OTHER: pharmacological study|PROCEDURE: therapeutic conventional surgery|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety, Tolerability, and Efficacy of the Omega System for the Treatment of LUTS Due to BPH
Status: RECRUITING
Conditions: Lower Urinary Tract Symptoms|Benign Prostatic Hyperplasia
Interventions: DEVICE: Omega device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Moderate Weight Loss Makes Obese Patients With Severe Chronic Plaque Psoriasis Responsive to Sub-Optimal Dose of Cyclosporine: an Investigator Blinded, Controlled, Randomized Clinical Trial
Status: COMPLETED
Conditions: Chronic Plaque Psoriasis|Obesity
Interventions: OTHER: low calorie diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Chronic ACE and DPP4 Inhibition on Blood Pressure
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Hypertension
Interventions: DRUG: Placebo|DRUG: Sitagliptin|DRUG: Aprepitant|OTHER: Mixed Meal Test (MMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Association Mechanical Prophylaxis + Anticoagulant Prophylaxis on Venous Thromboembolism Incidence in Intensive Care Unit (ICU)
Status: COMPLETED
Conditions: No High Risk of Hemorrhage
Interventions: DEVICE: Intermittent pneumatic compression of the lower limbs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention to Support the Reintegration of Former Combatants and Soldiers
Status: UNKNOWN
Conditions: Appetitive Aggression|Post-traumatic Stress Disorder
Interventions: BEHAVIORAL: NET for Forensic Offender Rehabilitation (FORNET): a variant of Narrative Exposure Therapy|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Administration of MELPIDA to Determine the Safety and Efficacy for Patients With Spastic Paraplegia Type 50
Status: ACTIVE_NOT_RECRUITING
Conditions: Spastic Paraplegia Type 50
Interventions: BIOLOGICAL: MELPIDA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Difference in Efficacy Between Stem Cell Transplantation and Classical Therapy in Liver Cirrhosis Patients
Status: UNKNOWN
Conditions: Liver Cirrhosis
Interventions: PROCEDURE: stem cell transplantation through interventional procedure|DRUG: antiviral therapy (lamivudine, other antiviral drugs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics and Safety Between HCP2202 and Co-administration of Each Component in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HCP2202|DRUG: RLD2202|DRUG: RLD2203
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young Adults
Status: TERMINATED
Conditions: Desmoplastic Small Round Cell Tumor|Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Recurrent Desmoplastic Small Round Cell Tumor|Recurrent Malignant Peripheral Nerve Sheath Tumor|Recurrent Malignant Solid Neoplasm|Recurrent Neuroblastoma|Recurrent Rhabdomyosarcoma|Refractory Desmoplastic Small Round Cell Tumor|Refractory Malignant Peripheral Nerve Sheath Tumor|Refractory Malignant Solid Neoplasm|Refractory Neuroblastoma|Refractory Rhabdomyosarcoma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility, Tolerability and Efficacy of the Ketogenic Diet in Children With Drug-resistant Epilepsy in South Vietnam
Status: COMPLETED
Conditions: Drug Resistant Epilepsy|Ketogenic Diet|Feasibility|Tolerability|Efficacy|Children
Interventions: DIETARY_SUPPLEMENT: Ketogenic diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET/CT and Bacterial/Fungal PCR in High Risk Febrile Neutropenia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Haematopoietic Stem Cell Transplant, Autologous|Haematopoietic Stem Cell Transplant, Allogeneic|Febrile Neutropenia
Interventions: DIAGNOSTIC_TEST: FDG-PET/CT|DIAGNOSTIC_TEST: Conventional CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Oral Administration of Anti-CD3 Monoclonal Antibody (mAb)in Patients With the Metabolic Syndrome
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis
Interventions: DRUG: OKT3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Simplified Cognitive Behavioral Therapy for Generalized Anxiety Disorder and Depression
Status: UNKNOWN
Conditions: Generalized Anxiety Disorder|Major Depressive Disorder
Interventions: BEHAVIORAL: SCBT|DRUG: SSRIs and/or SNRIs|BEHAVIORAL: Psychological Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: My Symptoms - Feasibility Study
Status: COMPLETED
Conditions: Persistent Physical Symptoms
Interventions: BEHAVIORAL: My Symptoms 1 (MySt-1)|BEHAVIORAL: My Symptoms 2 (MySt-2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Study Assessing the Efficacy and Safety of STN1013600 Ophthalmic Solution 0.1% and 0.3% Compared With Placebo in Subjects With Presbyopia
Status: COMPLETED
Conditions: Presbyopia
Interventions: DRUG: 0.1% STN1013600 ophthalmic solution|DRUG: 0.3% STN1013600 ophthalmic solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect Of XP Endo Finisher Versus Ultrasonic Activated Irrigation On Post-operative Pain In Endodontic Treatment of Symptomatic Irreversible Pulpitis
Status: UNKNOWN
Conditions: Symptomatic Irreversible Pulpitis
Interventions: DEVICE: XP Endo Finisher|DEVICE: ultrasonic activated irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Self-Expanding Nitinol Stent Versus Balloon Angioplasty Alone for the Below The Knee Arteries(SENS-BTK)
Status: COMPLETED
Conditions: Critical Limb Ischemia|Infrapopliteal Arterial Occlusive Disease
Interventions: DEVICE: self-expanding nitinol stent|DEVICE: balloon angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pack Cross Linking for Infectious Keratitis
Status: NOT_YET_RECRUITING
Conditions: Infectoius Keratitis
Interventions: DRUG: Riboflavin|DRUG: Antibotice.g vigamox ED Antifungal e.g Dflucan|DEVICE: pack cross linking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Fluid Milk on Post-meal Glycemia and Insulinemia in Overwt/Obese Adults
Status: COMPLETED
Conditions: Blood Glucose|Blood Insulin
Interventions: OTHER: Acute beverage (water) consumption|OTHER: Acute beverage (Black Coffee) consumption|OTHER: Acute beverage (Orange Juice) consumption|OTHER: Acute beverage (Whole Milk) consumption|OTHER: Acute beverage (2% Milk) consumption|OTHER: Acute beverage (Skim Milk) consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Intravascular Monitoring of Partial PRessure of Oxygen for Neonatal intensiVE Care Patients
Status: TERMINATED
Conditions: Catheters|Oxygen Saturation|Newborn, Infant, Disease
Interventions: DEVICE: Neosense Umbilical Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Preoperative Explanatory Videos in Total Extraperitoneal Inguinal Hernioplasty on Information Providing: a Multicenter Randomized Controlled Trial
Status: RECRUITING
Conditions: Inguinal Hernia
Interventions: OTHER: Explanatory video|OTHER: Informed consent form
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase 3 Papulopustular Rosacea Study
Status: COMPLETED
Conditions: Papulopustular Rosacea (PPR)
Interventions: DRUG: CD5024|DRUG: Azelaic acid 15% Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Darolutamide + Androgen Deprivation Therapy (ADT) in Chinese Men With High Risk, Nonmetastatic Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Darolutamide 600 mg twice daily|DRUG: Androgen deprivation therapy (ADT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of CYT387 in Primary Myelofibrosis (PMF) or Post-polycythemia Vera (PV) or Post-essential Thrombocythemia (ET)
Status: COMPLETED
Conditions: Primary Myelofibrosis|Post-Polycythemia Vera Myelofibrosis|Post-Essential Thrombocythemia Myelofibrosis
Interventions: DRUG: CYT387
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antiviral Agents Against COVID-19 Infection
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Atazanavir|DRUG: Daclatasvir 60 mg|DRUG: Sofusbuvir + Daclastavir 60 mg|DRUG: Placebo Atazanavir|DRUG: Placebo Daclatasvir 60 mg|DRUG: Placebo Sofusbuvir + Daclatasvir 60 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Reprogramming Therapy for Treatment of Recurrent Head and Neck Cancers
Status: COMPLETED
Conditions: Head and Neck Cancer|Head and Neck Cancers
Interventions: DRUG: Dichloroacetate|DEVICE: EF5
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy Tretinoin Cream in the Treatment of Axillary Hyperpigmentation Associated With Acanthosis Nigricans
Status: COMPLETED
Conditions: Acanthosis Nigricans|Hyperpigmentation
Interventions: DRUG: 0.025% Tretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-center Trial of IMPaCT CHW Support for Chronically-ill Patients
Status: COMPLETED
Conditions: Hypertension|Diabetes|Obesity|Tobacco Dependence
Interventions: BEHAVIORAL: IMPaCT|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intrathecal Nalbuphine Versus Midazolam in Cesarean Section
Status: COMPLETED
Conditions: Cesarean Section Pain
Interventions: DRUG: Bupivacaine|DRUG: Nalbuphine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Impact of Specific Monitoring of Intraoperative Analgesia Under General Anesthesia on Chronic Pain After Ovarian Cancer Surgery
Status: RECRUITING
Conditions: Ovarian Neoplasm
Interventions: OTHER: Arm A : intraoperative ANI monitoring of nociception|OTHER: Arm B : no specific monitoring of nociception
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER