pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Newborn Head Molding and Later Asymmetries
Status: ENROLLING_BY_INVITATION
Conditions: Plagiocephaly
Interventions: BEHAVIORAL: Newborns with preventive caring advices|OTHER: Newborns with normal caring advices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity & Reactogenicity of HBV-MPL Vaccine and Engerix™-B in Healthy Adults Following 2 Different Schedules
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Engerix™-B|BIOLOGICAL: HBV-MPL vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Growth, Safety, and Efficacy of an Infant Formula for Healthy Term Infants
Status: COMPLETED
Conditions: Infants|Newborn
Interventions: OTHER: Study Formula (SF)|OTHER: Comparator Formula (CF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Cross-over Study of OligoG in Subjects With Cystic Fibrosis. Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: OligoG CF-5/20|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fludarabine and 400 CGY Total Body Irradiation for Recipients of HLA-Matched or Mis-Matched Family or Unrelated Donor Hematopoietic Stem Cell Transplants Who Have Rejected Their First Allogeneic Stem Cell Transplant
Status: UNKNOWN
Conditions: Graft Failure
Interventions: PROCEDURE: Allogeneic hematopoietic stem cell graft using an allogeneic SCT HLA-Identical or non-identical family donor or unrelated donors|DRUG: fludarabine|PROCEDURE: TBI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcome of Overweight AF Patients Following Ablation With a Potential Weight Loss Medication ( GOAL-AF )
Status: RECRUITING
Conditions: Atrial Fibrillation|Recurrence|Overweight and Obesity|Liraglutide
Interventions: DRUG: Liraglutide plus upstream risk factors modification advice and consultation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose Finding Study for Combination of Capecitabine, Lapatinib and Vinorelbine in Metastatic Breast Cancer
Status: TERMINATED
Conditions: Metastatic Breast Cancer|HER2 Positive|First or Second Line Therapy|Failure or Contraindication of Trastuzumab Therapy
Interventions: DRUG: Lapatinib and Capecitabine and Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Bexarotene in Inducing Susceptibility to Chemotherapy in Metastatic TNBC
Status: RECRUITING
Conditions: Metastatic Triple-Negative Breast Carcinoma
Interventions: DRUG: Bexarotene|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Eye Movement Desensitization & Reprocessing Versus Cognitive Behavioral Therapy in Post-Traumatic Stress and Depressive Disorders
Status: COMPLETED
Conditions: Efficacy of Psychotherapy
Interventions: BEHAVIORAL: CBT Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Investigate CT38 in the Treatment of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome
Status: COMPLETED
Conditions: Myalgic Encephalomyelitis|Chronic Fatigue Syndrome
Interventions: DRUG: CT38
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Natural History of Autosomal Dominant Optic Atrophy (ADOA), Caused by OPA1 Mutation
Status: RECRUITING
Conditions: Autosomal Dominant Optic Atrophy|Optic Atrophy, Autosomal Dominant|Optic Atrophies, Hereditary|Kjer Optic Atrophy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pharmacodynamic and Pharmacokinetic Study of RO4917838 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: RO4917838|DRUG: Placebo to RO4917838|OTHER: Alcohol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Recession Coverage Using Modified Coronally Advanced Tunnel(MCAT)
Status: RECRUITING
Conditions: Gingival Recession
Interventions: PROCEDURE: MCAT + subepithelial connective tissue graft|PROCEDURE: MCAT + enamel matrix derivate|PROCEDURE: MCAT + subepithelial connective tissue graft + enamel matrix derivative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Gefapixant (AF-219/MK-7264) on Methacholine Hyper-reactivity in Participants With Asthma (MK-7264-009)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Gefapixant 50 mg|DRUG: Gefapixant 300 mg|DRUG: Placebo to mimic 50 mg tablets|DRUG: Placebo to mimic 300 mg tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Study of the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly Suspension to Sitagliptin and Placebo in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Type 2
Interventions: DRUG: Exenatide once weekly suspension|DRUG: Sitagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Pleiotropic Effect of Statins in Patients With Peripheral Arterial Disease
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DRUG: Atorvastatin|DRUG: Standard Medical Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Telemonitoring to Improve Outcomes of Patients With Chronic Kidney Disease (CKD)
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DEVICE: Video Telemonitoring Device with Clinical Care Modules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase Ib/II Study Assessing the Clinical Activity and Safety of Brexucabtagene Autoleucel as a Consolidation in Patients With Relapsed/Refractory (R/R) and Newly Diagnosed B-cell Acute Lymphocytic Leukemia (ALL) Post Cytoreduction With Mini-HCVD-inotuzumab-blinatumomab/HCVAD-inotuzumab-blinatumomab
Status: RECRUITING
Conditions: Relapsed/Refractory|B-cell Acute Lymphocytic Leukemia
Interventions: DRUG: Blinatumomab|DRUG: Inotuzumab Ozogamicin|DRUG: Hyper-CVAD|DRUG: Mini-hyper-CVD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antibiotic Impregnated Bone Graft to Reduce Infection in Hip Replacement.
Status: RECRUITING
Conditions: Arthroplasty, Replacement, Hip|Osteoarthritis, Hip|Antibiotic Resistant Infection|Prosthetic Joint Infection
Interventions: DRUG: Vancomycin + Tobramycin|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of EDP 305 in Healthy Subjects and Subjects With Presumptive NAFLD
Status: COMPLETED
Conditions: Presumptive NAFLD
Interventions: DRUG: EDP 305|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GOS and Microbial Fermentation in Aging
Status: COMPLETED
Conditions: Healthy Young Adults|Prefrail Elderly
Interventions: DIETARY_SUPPLEMENT: Galacto-oligosacchride|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Single-Dose Cross-Over Study of the Effects of Albuterol-HFA in Exercise Induced Bronchoconstriction
Status: TERMINATED
Conditions: Asthma|Bronchospasm
Interventions: DRUG: albuterol (Armstrong Albuterol HFA)|DRUG: Albuterol Sulfate (Provenetil-HFA)|DRUG: Placebo-HFA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: JALYN for Benign Prostatic Hyperplasia (BPH) and Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)
Status: TERMINATED
Conditions: Benign Prostatic Hyperplasia|Chronic Prostatitis
Interventions: DRUG: Jalyn|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Vestibular Rehabilitation for Improving Health Status in Patients With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia|Vestibular Disease|Postural Balance|Vestibular Rehabilitation
Interventions: OTHER: Vestibular Rehabilitation Exercises|OTHER: Conventional Rehabilitation exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Conventional Platelet-Rich Plasma Versus Concentrated Bone Marrow Stem Cell Injections for Osteoarthritis of the Knee
Status: WITHDRAWN
Conditions: Osteo Arthritis Knee
Interventions: BIOLOGICAL: Concentrated Bone Marrow Aspirate (BMAC)|BIOLOGICAL: Platelet-Rich Plasma (PRP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Anterior Cruciate Ligament Reconstruction: Residual Rotational Laxity for Single Versus Double Bundle Techniques
Status: TERMINATED
Conditions: Anterior Cruciate Ligament Injury
Interventions: PROCEDURE: Single bundle anterior cruciate ligament reconstruction|PROCEDURE: Double bundle anterior cruciate ligament reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Explore the Pharmacokinetics and Pharmacodynamics of Epinephrine in Healthy Male and Female Subjects With Different Skin to Muscle Depth (STMD)
Status: COMPLETED
Conditions: Anaphylaxis
Interventions: DEVICE: Part 1|DEVICE: Part 2 Group 1|DRUG: Part 2 group 2|DEVICE: Part 2 group 3|DEVICE: Part 2 Group 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: USG-guided M-TAPA vs OSTAP Block in Patients Undergoing Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Laparoscopic Cholecystectomy
Interventions: PROCEDURE: M-TAPA block|PROCEDURE: OSTAP block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Epidermal Expansion System for Epidermal Grafting on Hypopigmented Skin and Surgical Wounds
Status: UNKNOWN
Conditions: Surgical Wound|Hypo-pigmented Skin
Interventions: DEVICE: Momelan Technologies Epidermal Graft Harvesting System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants
Status: COMPLETED
Conditions: Noninvasive Ventilation for Respiratory Distress Syndrome
Interventions: DEVICE: Nasal CPAP (SLE)|DEVICE: Nasal IMV (SLE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Should We Use Oral Valacyclovir in Acute Herpetic Gingivostomatitis in Children?
Status: COMPLETED
Conditions: Herpetic Gingivostomatitis
Interventions: DRUG: Valacyclovir|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Custom Compression Garments on Standing Static Balance in Ehlers Danlos Syndrome
Status: COMPLETED
Conditions: Ehlers-Danlos Syndrome
Interventions: OTHER: Evaluate the variation in the travel speed of the "center of pressure" with and without compression garments.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Swept Source Enhanced Depth Imaging Optical Coherence Tomography
Status: UNKNOWN
Conditions: Retina, Choroid, Sclera
Interventions: DEVICE: DRI-1 Swept source OCT, Atlantis, Topcon
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Maximizing Lymph Node Dissection on Fresh and Fixed Lung Cancer Resection Specimens
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer|Lymph Node Metastasis|Pathologic Processes
Interventions: OTHER: Subjects undergoing a lung specimen lymph node dissection|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of RC48-ADC in Subjects With HER2 Overexpressed Metastatic Biliary Tract Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Biliary Tract Cancer
Interventions: DRUG: RC48-ADC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Mobilization Techniques With Common Use of Interferential Therapy in Patients With Knee OA
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Maitland's mobilization technique|OTHER: Mulligan's mobilization techniques|OTHER: Interferential Therapy (IFT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low Volume High Intensity Interval Training in Operated Lung Cancer Patients
Status: RECRUITING
Conditions: Lung Cancer|Non Small Cell Lung Cancer
Interventions: BEHAVIORAL: Low Volume High Intensity Exercise Training|BEHAVIORAL: Aerobic Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Disitamab Vedotin (RC48) in Combination With AK104 (PD-1/CTLA-4 Bispecific) and Bevacizumab for the Treatment of Recurrent and Persistent Clear Cell Ovarian Cancer: a Single-arm, Phase II, Multicenter Study (DAB OCC Study)
Status: NOT_YET_RECRUITING
Conditions: Ovary Cancer
Interventions: DRUG: Disitamab vedotin in combination with AK104 and bevacizumab for the treatment of recurrent and persistent clear cell ovarian cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Evaluating the Safety of a Lactate Releasing Vaginal Ring for the Prophylaxis of Bacterial Vaginosis
Status: COMPLETED
Conditions: Vaginosis, Bacterial
Interventions: DEVICE: Vaginal ring releasing lactic acid (racemic mixture)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Immediate Effects of Lucentis® in Conjunction With Photodynamic Therapy With Visudyne® in Exudative AMD(IECOMB)
Status: COMPLETED
Conditions: Age Related Macular Degeneration
Interventions: DRUG: Intravitreal ranibizumab with photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PATHOS Study Pain Assessment in Thoracic Oncologic Surgery
Status: COMPLETED
Conditions: Pain, Postoperative|Lung Neoplasm
Interventions: DRUG: Ropivacaine for Serratus Plane Block (SPB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of HAT01H in Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis|Eczema
Interventions: DRUG: HAT01H Cream|DRUG: Vehicle Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Nebivolol on Skeletal Muscle During Exercise in Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Metoprolol succinate|DRUG: Nebivolol|PROCEDURE: Non-invasive measurement of Cardiac Output (CO)|PROCEDURE: Endothelial cell collection|PROCEDURE: Microvascular perfusion assessment using Definity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: High-Dose Gemcitabine, Busulfan and Melphalan for Patients With Refactory Hodgkin's Disease
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Gemcitabine|DRUG: Busulfan|DRUG: Melphalan|PROCEDURE: Stem Cell Transplantation|DRUG: Palifermin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ambrisentan (Letairis) for Sarcoidosis Associated Pulmonary Hypertension
Status: COMPLETED
Conditions: Sarcoidosis|Pulmonary Hypertension
Interventions: DRUG: Ambrisentan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cells in a Clinical Trial to Heal Articular Cartilage Defects
Status: UNKNOWN
Conditions: Defect of Articular Cartilage
Interventions: PROCEDURE: stem cells|PROCEDURE: Chondrocytes|OTHER: Rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Practical Use of Transthoracic Echocardiography for Obtaining an Optimal Depth of Internal Jugular Venous Catheters in Infants
Status: COMPLETED
Conditions: Insertion Depth of Central Venous Catheter
Interventions: PROCEDURE: transthoracic echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Response Modulation Hypothesis of Socioemotional Processing Associated With Alcohol Use Disorder
Status: RECRUITING
Conditions: Healthy Volunteers|Alcohol Drinking Related Problems|Alcohol-Related Disorders
Interventions: BEHAVIORAL: Real time fMRI neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Kinect Sensor in Cerebral Palsy Children: Phase 2.1
Status: WITHDRAWN
Conditions: Cerebral Palsy Children|Upper Extremity Problem
Interventions: DEVICE: the engineer-built system, video-game based Kinect sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Clinical Safety of Levofloxacin 1.5% vs Topical Moxifloxacin 0.5%
Status: UNKNOWN
Conditions: Endophthalmitis Postoperative
Interventions: DRUG: Levofloxacin Ophthalmic Product|DRUG: Moxifloxacin Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Validity of Humidity Ramp Protocols for Identifying Limits of Survivability in Heat-exposed Persons
Status: COMPLETED
Conditions: Heat Stress|Heat Exposure|Temperature Change, Body|Temperature; Extreme, Exposure
Interventions: OTHER: Humidity-ramp protocol|OTHER: Above-inflection fixed-condition exposure|OTHER: Below-inflection fixed-condition exposure|OTHER: Control fixed-condition exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Observation of the Clinical Efficacy of Two Surgical Procedures for Varus Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: OWHTO|PROCEDURE: CWHTO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gene Expression Analysis of Patients With Metastatic Colorectal Cancer Receiving Oxaliplatin Based Chemotherapy Regimen
Status: COMPLETED
Conditions: Colonic Diseases|Cancer
Interventions: DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Course Radiotherapy With Sequential Disitamab Vedotin Combined With S-1 and Sintilimab as Whole Course Neoadjuvant Therapy for HER2 Expressed Locally Progressive Gastric Cancer
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Short range radiotherapy with sequential Disitamab Vedotin combined with S-1 and xindilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of N-acetylcysteine on Renal Functioning of Chronic Kidney Diseases(CKD) Patients After General Anesthesia
Status: UNKNOWN
Conditions: Chronic Kidney Diseases|General Anesthesia
Interventions: DRUG: N-acetylcysteine|DRUG: Siran (N-acetylcysteine)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Urinary Leakage in the Indwelling Urinary Catheterization
Status: COMPLETED
Conditions: Urine Leakage in the Indwelling Urinary Catheterization
Interventions: PROCEDURE: The use of different types and volumes of solutions to inflate the catheter balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Dapagliflozin in Acute Heart Failure
Status: COMPLETED
Conditions: Heart Failure|Diabetes Mellitus, Type 2
Interventions: DRUG: Dapagliflozin 10 MG|OTHER: Protocolized Diuretic Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open Label, Multicenter, Phase II Study of Dacomitinib for EGFR Mutated Non-Small Cell Lung Cancer (NSCLC) With Brain Metastases
Status: UNKNOWN
Conditions: Dacomitinib for EGFR Mutated Non-Small Cell Lung Cancer (NSCLC) With Brain Metastases
Interventions: DRUG: Dacomitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Increasing Household Purchase and Child Consumption of Calcium Products
Status: COMPLETED
Conditions: Dietary Modification
Interventions: BEHAVIORAL: Mail-out hard copy materials (education plus self-regulatory strategies examples)|BEHAVIORAL: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination of the Hedgehog Inhibitor, LDE225, With Etoposide and Cisplatin in the First-Line Treatment of Patients With Extensive Stage Small Cell Lung Cancer (ES-SCLC)
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: LDE225, Etoposide and Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Melatonin on Oxidative Stress in Obese Adults (MELASTRESSOB)
Status: RECRUITING
Conditions: Obesity
Interventions: OTHER: BWRP|OTHER: BWRP + melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Assessment of Methylprednisolone and Heparin in Patients With COVID-19 Pneumonia
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: Methylprednisolone|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SELUTION SLR™ 014 In-stent Restenosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Restenosis
Interventions: DEVICE: SELUTION SLR™ DEB|DEVICE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Personal Technology Driven Workplace Wellbeing Intervention Programme on Wellbeing, Productivity (Presenteeism) and Absenteeism - an Intervention Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Occupational Stress|Occupational Burnout
Interventions: BEHAVIORAL: Psychological health and flexibility|BEHAVIORAL: Work ability|BEHAVIORAL: Sleep and recovery|BEHAVIORAL: Healthy lifestyle|OTHER: No coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Safety and Efficacy Study of RGN-137 Topical Gel for Junctional and Dystrophic Epidermolysis Bullosa
Status: TERMINATED
Conditions: Junctional Epidermolysis Bullosa|Dystrophic Epidermolysis Bullosa
Interventions: DRUG: RGN-137|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Procaterol Hydrochloride to Treat Patients With Cough Variant Asthma (CVA)
Status: UNKNOWN
Conditions: Cough Variant Asthma
Interventions: DRUG: Procaterol hydrochloride|DRUG: Meptin placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of IMRT Treatment With Inhomogeneous Dose in Patients With Relapsed High-grade Gliomas.
Status: COMPLETED
Conditions: Glioblastoma Multiforme|Glioblastoma|Glioblastoma, Adult
Interventions: RADIATION: Hypofractionation guioded by dose painting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebral Hemodynamic Optimization by Milrinone to Prevent Delayed Cerebral Ischemia
Status: RECRUITING
Conditions: Aneurysmal Subarachnoid Hemorrhage
Interventions: DRUG: Milrinone Injection|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FLT PET/CT in Measuring Response in Patients With Previously Untreated Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|DRUG: Chemotherapy|PROCEDURE: Computed Tomography|DRUG: Cytarabine|OTHER: Fluorothymidine F-18|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Surgeon-Patient Communication: A Randomized Controlled Trial Evaluating the Impact of an Orthopaedic Related Smoking Cessation Discussion After Fracture Surgery
Status: TERMINATED
Conditions: Orthopaedic Decision Making
Interventions: BEHAVIORAL: Intervention|BEHAVIORAL: Verbal Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Lyophilized Food Extracts for Skin Prick Tests and Atopy Patch Test at Different Storage Time
Status: COMPLETED
Conditions: Food Allergy
Interventions: DIAGNOSTIC_TEST: skin test with food at different storage times
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Potential of a Low Oxygen Environmental Chamber as an Aid to Exercise Training to Improve Metabolic Health
Status: COMPLETED
Conditions: Overweight|Physical Inactivity|Healthy
Interventions: OTHER: Low-moderate intensity exercise under normoxia|OTHER: Low-moderate intensity exercise under moderate hypoxia|OTHER: Low-moderate intensity exercise under high hypoxia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Ilioinguinal Nerve Block on Chronic Pain in Patients in Inguinal Hernia With Spinal Anesthesia
Status: COMPLETED
Conditions: Ilioinguinal Nerve Block
Interventions: PROCEDURE: Research on the effects of Ilioinguinal Nerve Block on Chronic Pain in Patients who undergo Inguinal Hernia with Spinal Anesthesia|PROCEDURE: Ilioinguinal nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Brain Maturation in Children With Localization Related Epilepsy
Status: COMPLETED
Conditions: Benign Childhood Epilepsy With Centro-temporal Spikes (BCECTS)|Focal Cryptogenic Epilepsy of Childhood|Cryptogenic Epilepsy of Childhood
Interventions: PROCEDURE: MRI|PROCEDURE: functional MRI (fMRI)|BEHAVIORAL: neuropsychological assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Acupuncture on Patients With Crohn's Disease in Remission
Status: RECRUITING
Conditions: Crohn Disease|Inflammatory Bowel Diseases
Interventions: OTHER: acupuncture|OTHER: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of IV CR845 in Hemodialysis Patients, and Its Efficacy in Patients With Uremic Pruritus
Status: COMPLETED
Conditions: Pruritus|Uremic Pruritus
Interventions: DRUG: Part A: Placebo|DRUG: Part A: CR845 0.5 mcg/kg|DRUG: Part A: CR845 1.0 mcg/kg|DRUG: Part A: CR845 2.5 mcg/kg|DRUG: Part B: Placebo|DRUG: Part B: CR845 1.0 mcg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Nelotanserin for Treatment of Visual Hallucinations in Subjects With Lewy Body Dementia
Status: COMPLETED
Conditions: Lewy Body Dementia|Visual Hallucinations
Interventions: DRUG: Nelotanserin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of L-ornithine-L-aspartate (LOLA) on Plasma Ammonia in Cirrhotic Patients After TIPS
Status: COMPLETED
Conditions: Decompensated Cirrhosis|Portal Hypertension|Bleeding Varices|Refractory Ascites
Interventions: DRUG: L-ornithine-L-aspartate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Morning Snack on Cognitive Performance in Adults
Status: COMPLETED
Conditions: Nutrition|Cognitive Change|Food Intake Control|Satiety
Interventions: OTHER: Control|OTHER: White chocolate|OTHER: Dark chocolate 1|OTHER: Dark chocolate 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Hormonal Regulation of Body Weight Maintenance
Status: COMPLETED
Conditions: Obesity|Weight Loss|Weight Gain|Hormone Disturbance|Adipose Tissue|Insulin Resistance|Skeletal Muscle
Interventions: BEHAVIORAL: multimodal lifestyle intervention|BEHAVIORAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Behavioral/Pharmacological Therapy for Insomnia
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders
Interventions: BEHAVIORAL: Cognitive-Behavioral Therapy for Insomnia|DRUG: zolpidem tartrate (Ambien)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of the Ultrasound-Guided Retroclavicular Brachial Plexus Block
Status: WITHDRAWN
Conditions: Anesthesia|Upper Extremity Injury
Interventions: PROCEDURE: Retroclavicular Brachial Plexus Block and Catheter Insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Circuitry-Guided Smoking Cessation in Schizophrenia
Status: COMPLETED
Conditions: Smoking Cessation|Nicotine Addiction|Schizophrenia
Interventions: DEVICE: Active TMS stimulation|DEVICE: Sham TMS stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effects of Cricket- and Beef-derived Protein on Plasma Amino Acid Concentrations and Appetite Responses
Status: COMPLETED
Conditions: Aminoacidemia|Appetitive Behavior
Interventions: DIETARY_SUPPLEMENT: Cricket-derived Protein|DIETARY_SUPPLEMENT: Beef-derived Protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Aprepitant for Nause and Vomiting Induced by Chemoradiotherapy in HNSCC
Status: COMPLETED
Conditions: Vomiting|Nausea Post Chemotherapy|Head Neck Cancer
Interventions: DRUG: Aprepitant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Corticosteroids for the Treatment of Transient Tachypnea of the Newborn
Status: UNKNOWN
Conditions: Transient Tachypnea of the Newborn
Interventions: DRUG: Experimental group: Budicort by Inhalation|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized Dietary Advice 3 Months After Discharge From Hospitalization in Geriatrics: Effect on Nutritional Status According to Coronavirus Disease 2019 (COVID-19) Status (Positive or Negative) During Hospitalization
Status: COMPLETED
Conditions: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Interventions: BEHAVIORAL: Post-hospitalization nutritional monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Physical Activity, Posture and Body Composition in Ontogeny
Status: ACTIVE_NOT_RECRUITING
Conditions: Pediatric Obesity|Postural Balance|Physical Activity
Interventions: OTHER: psychoprophylactic program aimed at normalizing body weight through medical training|OTHER: psychoprophylactic program aimed at improving body posture|OTHER: psychoprophylactic program aimed at improving physical fitness|DIAGNOSTIC_TEST: Body composition assessment|DIAGNOSTIC_TEST: assessment of body posture using the Kasperczyk method|DIAGNOSTIC_TEST: Assessment of physical fitness|DIAGNOSTIC_TEST: Balance assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Prospective, Multicenter, Single-arm Study to Evaluate a Transcatheter Aortic Valve System Safety and Efficacy for the Treatment of Patients With Severe Aortic Stenosis
Status: RECRUITING
Conditions: Severe Aortic Stenosis
Interventions: PROCEDURE: Transcatheter aortic valve replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Different Doses (Mass) of Local Anesthetic on Duration of Adductor Canal Block in Healthy Volunteers - Part 2
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Adductor canal block with 20 ml lidocaine, single bolus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Antioxidant Therapy in Patients With Septic Shock
Status: UNKNOWN
Conditions: Oxidative Stress|Septic Shock
Interventions: DRUG: Melatonin 5 mg|DRUG: Vitamin C 1 GM Oral Tablet|DRUG: Vitamin E 400 UNT|DRUG: N-acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ontak (Denileukin Diftitox) in Patients With Systemic Mastocytosis (SM)
Status: COMPLETED
Conditions: Leukemia|Systemic Mastocytosis
Interventions: DRUG: Ontak (Denileukin Diftitox)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Umbilical Cord Blood Stem Cell Transplantation in Adults With Advanced Blood Disorders or Cancer
Status: COMPLETED
Conditions: Hematologic Neoplasms
Interventions: PROCEDURE: Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Riluzole to Treat Post-traumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: PTSD
Interventions: DRUG: Riluzole|DRUG: Placebo (for Riluzole)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The LvL UP Pilot Trial
Status: RECRUITING
Conditions: Health Behavior|Noncommunicable Diseases|Mental Health Issue|Lifestyle Risk Reduction
Interventions: BEHAVIORAL: LvL UP|BEHAVIORAL: LvL UP + MI|BEHAVIORAL: Comparison
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing Soybean Oil-Based (Intralipid) With an Olive Oil-Based (ClinOleic) Lipid Emulsion on Healthy Volunteers
Status: COMPLETED
Conditions: Diseases, Metabolic|Insulin Sensitivity
Interventions: DRUG: Intralipid|DRUG: ClinOleic|DRUG: Dextrose|OTHER: Saline (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Antagonism of Opioid-Induced Respiratory Depression by CX1739 With Preservation of Opioid Analgesia
Status: UNKNOWN
Conditions: Opiate Induced Respiratory Depression
Interventions: DRUG: CX1739 - 300 mg|DRUG: CX1739 - 600 mg|DRUG: CX1739 - 900 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of an Anti-HIV Drug Combination That Includes a Coated Form of Didanosine (ddI EC) Compared to a Typical Anti-HIV Drug Regimen
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Lamivudine/Zidovudine|DRUG: Nelfinavir mesylate|DRUG: Stavudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of ATs in Patients With Dry Eye Syndrome
Status: COMPLETED
Conditions: Dry Eye Syndromes|Keratoconjunctivitis Sicca
Interventions: DRUG: AT01|DRUG: AT02|DRUG: AT03|DRUG: AT04
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Physical Exercise, Endothelial Function and Progenitor Endothelial Cells in Systemic Lupus Erythematosus Patients
Status: UNKNOWN
Conditions: Systemic Lupus Erythematosus
Interventions: BEHAVIORAL: Supervised physical exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Safety and Efficacy of Osimertinib and Amivantamab in Participants With Non-small Cell Lung Cancer With Common Epidermal Growth Factor Receptor Mutations
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer (NSCLC)
Interventions: DRUG: Osimertinib|DRUG: Amivantamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Trial of ZD4054 (Zibotentan) (Endothelin A Antagonist) in Hormone Resistant Prostate Cancer With Bone Metastases
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: ZD4054|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ketamine in the Treatment of Suicidal Depression
Status: COMPLETED
Conditions: Major Depressive Disorder|Suicidal Ideation
Interventions: DRUG: Ketamine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Cell Lymphoma After Autologous Transplant
Status: COMPLETED
Conditions: B-cell Lymphoma|Non-Hodgkin's Lymphoma
Interventions: DRUG: Bexxar
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Clinical Study of 3D-printed Magnesium Alloy Prosthesis With Controllable Degradation Rate in the Repair of Periarticular Bone Defects
Status: RECRUITING
Conditions: Degradation of Magnesium Alloy Prosthesis and New Bone Regeneration
Interventions: DEVICE: 3D printed WE43 magnesium alloy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Near-Infrared Autofluorescence With PTH Test Strip as an SOP of Parathyroid in Thyroid Surgery
Status: COMPLETED
Conditions: Thyroid Cancer|Hypoparathyroidism|Optical Imaging
Interventions: DEVICE: Near-infrared devices|DIAGNOSTIC_TEST: PTH test strip
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomized Controlled Trial of Vitamin D3 Supplementation for Viral Upper Respiratory Tract Infections (URI) Prevention
Status: COMPLETED
Conditions: Viral Upper Respiratory Tract Infection
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: ACHIEVE Hearing Intervention Follow-Up Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Hearing Loss|Aging
Interventions: OTHER: Clinic-based audiological rehabilitative service delivery|OTHER: Telehealth audiological rehabilitative service delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Ultrasound- Guided Mid Point Transverse Process to Pleura Block
Status: COMPLETED
Conditions: Regional Anesthesia for Postnephrectomy Pain
Interventions: PROCEDURE: Mid transverse process to pleura block (MTP)|PROCEDURE: Mid transverse process to pleura Sham block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment for Adolescents With Deliberate Self Harm
Status: COMPLETED
Conditions: Intentional Self Harm
Interventions: BEHAVIORAL: Dialectical behavioral therapy for adolescents (DBT-A)|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selegiline Transdermal System for the Treatment of Cocaine Dependence - 1
Status: COMPLETED
Conditions: Cocaine-Related Disorders
Interventions: DRUG: Selegiline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Crizotinib in c-MET Mutation Metastatic/Recurrent/Persistent Endometrial Cancer
Status: UNKNOWN
Conditions: Endometrial Cancer Recurrent
Interventions: DRUG: Crizotinib 250 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of an Intramuscular Pandemic Influenza Vaccine in Adults and the Elderly
Status: COMPLETED
Conditions: Influenza|Orthomyxoviridae Infections
Interventions: BIOLOGICAL: A/H5N1 inactivated, split-virion influenza virus|BIOLOGICAL: A/H5N1 inactivated, split-virion influenza virus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Three Dimensional Evaluation of Apexogenesis of Immature Young Permanent Teeth With Different Endodontic Material
Status: RECRUITING
Conditions: Deep Carious Young 1st Permanent Molar With Open Apex
Interventions: PROCEDURE: endo-sequence putty|PROCEDURE: neo-MTA putty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT