pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Mechanisms of Glucose Counterregulation in Pancreatic Islet Transplantation
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: PROCEDURE: Hypoglycemic and euglycemic glucose clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Gasless Single-port Laparoscopic-assisted Radical Resection for Rectal Carcinoma
Status: UNKNOWN
Conditions: Laparoscopic Surgery
Interventions: PROCEDURE: gasless single-port laparoscopic surgery|PROCEDURE: conventional laparoscopic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Hemodynamic Response to to a Sublingual Dose of Glyceryl Trinitrate in Subjects Receiving TA-1790, Sildenafil Citrate, and Placebo
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: TA-1790|DRUG: Sildenafil citrate|DRUG: Placebo|DRUG: Nitrostat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Suture Techniques to Reduce the Incidence of Incisional Hernia: LTFU STITCH Trial
Status: RECRUITING
Conditions: Surgery|Incisional Hernia|Wound Infection|Fascial Dehiscence|Pain|Quality of Life
Interventions: PROCEDURE: Small bites technique|PROCEDURE: Conventional large bites closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Everolimus, Carboplatin, and Paclitaxel in Locally Advanced Head and Neck Cancer That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: carboplatin|DRUG: RAD001|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands)
Status: COMPLETED
Conditions: Venous Thrombosis|Pulmonary Embolism|Atrial Fibrillation|Acute Coronary Syndrome
Interventions: DRUG: Rivaroxoban (Xarelto, Bay59-7939)|DRUG: Standard of care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Basket Study (CT-100-002) to Evaluate the Effects of a DiNaMo™ Component Training
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Diabetic Neuropathy|Fibromyalgia|Irritable Bowel Syndrome
Interventions: DEVICE: DiNaMo Study App|DEVICE: Placebo App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of PRO 542 in the Treatment of HIV-Infected Patients
Status: COMPLETED
Conditions: HIV Infections|Acquired Immune Deficiency Syndrome
Interventions: DRUG: CD4-IgG2 (PRO 542)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Insulin Glargine "All to Target" Trial
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin Glulisine|DRUG: Insulin Glargine|DRUG: Premixed Insulin|DRUG: Insulin Glulisine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Hydrogel 1 Day Toric and Silicone Hydrogel Daily Disposable Toric
Status: ACTIVE_NOT_RECRUITING
Conditions: Astigmatism
Interventions: DEVICE: Lens A (Hydrogel Daily Disposable Toric Contact Lens)|DEVICE: Lens B (Silicone Hydrogel Daily Disposable Toric Contact Lens)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study on the Effects of Exercise on Side Effects From Treatment for Gastrointestinal Cancers
Status: RECRUITING
Conditions: Gastrointestinal Cancer
Interventions: BEHAVIORAL: structured treadmill walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Comparative CT Evaluation of the Amount of Root Resorption in Self-ligating Versus Conventional Brackets
Status: COMPLETED
Conditions: Root Resorption
Interventions: DEVICE: conventional brackets|DEVICE: smart clip passive self ligating brackets|DEVICE: Empower active self ligating brackets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Label Non-Randomized Dose Escalating Trial to Assess Safety and Tolerability of Alb-Interferon Alfa 2b Every Two Weeks With Ribavirin Among HIV/HCV Coinfected Individuals
Status: COMPLETED
Conditions: HIV Infections|HCV
Interventions: DRUG: Albinterferon|DRUG: Ribavirin|DRUG: Albuferon
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study to Compare Two Types of Insulin, a New Insulin, Insulin Icodec and an Available Insulin, Insulin Glargine, in People With Type 2 Diabetes Who Have Not Used Insulin Before
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin icodec|DRUG: Insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Tislelizumab Combined With Anlotinib and S1 Plus Oxaliplatin as Neoadjuvant Therapy for the Locally Advanced Adenocarcinoma of Esophagogastric Junction
Status: NOT_YET_RECRUITING
Conditions: Immunotherapy Gastroesophageal Junction
Interventions: DRUG: Tislelizumab|DRUG: Anlotinib|DRUG: Oxaliplatin|DRUG: Tegafur
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Analgesia in Laparoscopic Gynecological Surgeries
Status: NOT_YET_RECRUITING
Conditions: Postoperative Pain
Interventions: DRUG: Group M (lidocaine with Magnesium sulfate)|DRUG: Group B (lidocaine with Sodium bicarbonate)|DRUG: Group C (lidocaine with saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy
Status: RECRUITING
Conditions: B Acute Lymphoblastic Leukemia|B Lymphoblastic Lymphoma|Central Nervous System Leukemia|Mixed Phenotype Acute Leukemia|Testicular Leukemia
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Bone Scan|DRUG: Calaspargase Pegol|PROCEDURE: Computed Tomography|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Daunorubicin Hydrochloride|DRUG: Dexamethasone|DRUG: Doxorubicin Hydrochloride|BIOLOGICAL: Inotuzumab Ozogamicin|DRUG: Leucovorin Calcium|PROCEDURE: Magnetic Resonance Imaging|DRUG: Mercaptopurine|DRUG: Methotrexate|DRUG: Pegaspargase|PROCEDURE: Positron Emission Tomography|DRUG: Prednisolone|OTHER: Questionnaire Administration|RADIATION: Radiation Therapy|RADIATION: Radiation Therapy|DRUG: Thioguanine|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Impact of Indocyanine Green Titration on Fluorescent Intensity in Free Flap : An Exploration of Alternative Indicators
Status: ACTIVE_NOT_RECRUITING
Conditions: Free Flap|Indocyanine Green|Microsurgery|Temperature Change, Body
Interventions: DIAGNOSTIC_TEST: Indocyanine Green Fluorescence (ICG)|DIAGNOSTIC_TEST: Temperature|DIAGNOSTIC_TEST: Transcutaneous oxygen and carbon dioxide pressure|DIAGNOSTIC_TEST: Histopathology|DIAGNOSTIC_TEST: Hypoxia inducible factor-1 (HIF-1) alpha
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Tolerability and Pharmacokinetics of NN1731 in Healthy Volunteers
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Healthy
Interventions: DRUG: vatreptacog alfa (activated)|DRUG: vatreptacog alfa (activated)|DRUG: vatreptacog alfa (activated)|DRUG: vatreptacog alfa (activated)|DRUG: placebo|DRUG: placebo|DRUG: placebo|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bacteriophages for Treating Urinary Tract Infections in Patients Undergoing Transurethral Resection of the Prostate
Status: COMPLETED
Conditions: Intravesical Bacteriophage Treatment for Urinary Tract Infections
Interventions: BIOLOGICAL: PYO Phage|DRUG: Antibiotics|OTHER: Sterile bacteriology media
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Computerised Interventions for Thinking and Anxiety in Delusions (CITADEL) Trial
Status: COMPLETED
Conditions: Paranoia in People With Schizophrenia-spectrum Diagnosis
Interventions: OTHER: Anxiety intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis
Status: COMPLETED
Conditions: Cryptococcal Meningitis|Fungal Meningitis
Interventions: DRUG: Sertraline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-Operative Dosing of Dexamethasone in Patients With Brain Tumors After a Craniotomy, PODS Trial
Status: NOT_YET_RECRUITING
Conditions: Low Grade Glioma|Malignant Brain Glioma|Malignant Brain Neoplasm|Meningioma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Dexamethasone|PROCEDURE: Magnetic Resonance Imaging|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Matched Unrelated Donor T Cell Infusion for Hematologic Malignancies After Allo-HSCT
Status: WITHDRAWN
Conditions: Leukemia|Myelodysplastic Syndromes|Lymphomas|Multiple Myeloma|Other High-risk Hematological Malignancies
Interventions: BIOLOGICAL: rivogenlecleucel|DRUG: Rimiducid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Eslicarbazepine Acetate as Therapy in Subjects With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: Placebo|DRUG: ESL 400 mg|DRUG: ESL 800 mg|DRUG: ESL 1200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Cyclokapron for Treatment and Management of Women With Bleeding Disorders
Status: COMPLETED
Conditions: vonWillebrand Disease|Hemophilia|Platelet Coagulation Disorders
Interventions: DRUG: Cyclokapron
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Dato-DXd With or Without Durvalumab Versus Investigator's Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Without Pathological Complete Response Following Neoadjuvant Therapy (TROPION-Breast03)
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Dato-DXd|DRUG: Durvalumab|DRUG: Capecitabine|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electromyographic´s Differences Between Dry Needling in Tonic or Phasic Skeletal Muscle Fibers.
Status: UNKNOWN
Conditions: Muscle Disorder|Trigger Point Pain, Myofascial
Interventions: OTHER: Dry Needling in upper trapezius|OTHER: Dry Needling in lower trapezius
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxytocin Administration and Emotion Recognition Abilities in Adults Reporting Adverse Childhood Experiences
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxytocin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Efficacy, Safety, and Drug Levels of Oral Ozanimod in Pediatric Participants With Moderately to Severely Active Crohn's Disease With an Inadequate Response to Conventional Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn Disease
Interventions: DRUG: Ozanimod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Safety, Immunogenicity and Efficacy of a Candidate Malaria Vaccine in Tanzanian Infants
Status: COMPLETED
Conditions: Malaria|Malaria Vaccines
Interventions: BIOLOGICAL: RTS,S/AS02D|BIOLOGICAL: Engerix-B®|BIOLOGICAL: TETRActHib™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Timing of Transcranial Direct Current Stimulation (tDCS) for Enhancing Learning During Cognitive Training
Status: COMPLETED
Conditions: Effects on Learning
Interventions: DEVICE: Transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Metformin Glycinate, Treatment of Patients With COVID-19 and Severe Acute Respiratory Syndrome Secondary to SARS-CoV-2.
Status: COMPLETED
Conditions: Severe Acute Respiratory Syndrome Coronavirus 2
Interventions: DRUG: Metformin Glycinate|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Recombinant Novel Coronavirus Vaccine
Status: UNKNOWN
Conditions: Coronavirus
Interventions: BIOLOGICAL: Recombinant new coronavirus vaccine (CHO cell) low-dose group|BIOLOGICAL: Recombinant new coronavirus vaccine (CHO cells) high-dose group|BIOLOGICAL: Recombinant new coronavirus vaccine (CHO cells) placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Single-dose, Comparative Bioavailability Study of Two Formulations of Sarpogrelate HCl 300mg Tablets Under Feeding Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Anpl-one SR Tab. 300mg|DRUG: Sarpodipil SR Tab. 300mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Capnography in EGD and Colonoscopy With Moderate Sedation.
Status: COMPLETED
Conditions: Hypoxia|Apnea|Hypotension|Hypopnea
Interventions: DIAGNOSTIC_TEST: Capnographic Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Effect Of Moringa Leaf Extract On Disease Activity In Rheumatoid Arthritis Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Moringa Oleifera
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Chemotherapy in Clinical Local Advanced CRC Following Preoperational Therapies and pT0-3N0M0 Diagnosis
Status: RECRUITING
Conditions: Colorectal Cancer|Adjuvant Chemotherapy
Interventions: BEHAVIORAL: wait and watch|DRUG: adjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, Leucovorin, and Avastin
Status: COMPLETED
Conditions: Liver Cancer|Advanced Solid Tumors
Interventions: DRUG: Fluorouracil|DRUG: Avastin|DRUG: Leucovorin|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BIOFLOW-china Post-marketing Study (BIOTRONIK)
Status: ENROLLING_BY_INVITATION
Conditions: In-Stent Stenosis (Restenosis) of Coronary Artery Stent|Native Coronary Artery Stenosis
Interventions: DEVICE: BIOTRONIK Orsiro Sirolimus-Eluting Coronary Stent System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Liposomal Bupivacaine for Pain Control Following Thoracic Surgery.
Status: UNKNOWN
Conditions: Pain, Postoperative|Thoracic Diseases|Local Anesthetics Causing Adverse Effects in Therapeutic Use|Opioid Dependence
Interventions: DRUG: Liposomal bupivacaine|DRUG: Bupivacaine|DRUG: Epinephrine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Almorexant (ACT 078573) in Adult Subjects With Chronic Primary Insomnia
Status: COMPLETED
Conditions: Primary Insomnia
Interventions: DRUG: almorexant|DRUG: almorexant|DRUG: Placebo|DRUG: zolpidem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Parent SMART (Substance Misuse in Adolescents in Residential Treatment)
Status: RECRUITING
Conditions: Substance Use|Adolescent Behavior
Interventions: BEHAVIORAL: Parent SMART|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Latanoprost Versus Fotil
Status: COMPLETED
Conditions: Open-Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: latanoprost 0.005%|DRUG: Fotil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Serial Casting and Physical Therapy in Children With Idiopathic Toe Walking
Status: NOT_YET_RECRUITING
Conditions: Idiopathic Toe Walking
Interventions: OTHER: Serial Casting|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: UVX as an Adjuvant in the Treatment of Fungal Keratitis
Status: UNKNOWN
Conditions: Treatment
Interventions: DRUG: topical voriconazole / levofloxacin systemic itraconazole|RADIATION: CXL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remifentanil Versus Sufentanil for Intubation Condition Without Myorelaxant
Status: COMPLETED
Conditions: Anaesthetic Induction
Interventions: DRUG: Remifentanyl - sufentanil placebo|DRUG: Sufentanil - remifentanyl placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Post Market Clinical Follow-up Study on da Vinci® Robotic-assisted Prophylactic Nipple Sparing Mastectomy With Breast Reconstruction
Status: TERMINATED
Conditions: Prophylactic Nipple Sparing Mastectomy (NSM)
Interventions: PROCEDURE: Nipple-Sparing Mastectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mitochondrial Oxidation and Insulin Resistance in Burn Patients Treated With Fenofibrate
Status: WITHDRAWN
Conditions: Burn
Interventions: DRUG: fenofibrate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Etoricoxib in Acute Ankle Ligament Sprains
Status: WITHDRAWN
Conditions: Sprain
Interventions: DEVICE: Ankle brace|DRUG: Diclofenac 50 mg tds|DRUG: Etoricoxib 120 mg mane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Tolerability of PRO-190 Ophthalmic Solution Compared to Systane Ultra® on the Ocular Surface.
Status: NOT_YET_RECRUITING
Conditions: Dry Eye|Dry Eyes Chronic|Dry Eye Syndromes
Interventions: DRUG: PRO-190|DRUG: Systane Ultra®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Liraglutide on Sudomotor Function and Inflammation in Type 2 Diabetes
Status: UNKNOWN
Conditions: Autonomic Nervous System Diseases|Sweat Gland Diseases|Diabetic Neuropathy With Neurologic Complication
Interventions: DRUG: Liraglutide 6 mg Solution for Injection|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Specialized Technology Education for Pumps & Pens in Underserved Populations With Diabetes
Status: COMPLETED
Conditions: Type1diabetes
Interventions: OTHER: Education: Session 1 - Basics of type 1 management|OTHER: Session 2 - Carbohydrate counting|OTHER: Education: Session 3 - Insulin self- adjustment|OTHER: Education: Session 4 - Sick day rules and physical activity dose adjustments|OTHER: Education: Session 5 - Starting the insulin pen (for pen users) or pump (for pump users)|OTHER: Education: Session 6 - Trouble shooting the pump (for pump users)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase I Safety Trial of Streptococcus Pneumoniae Whole Cell Vaccine (SPWCV) + Alum in Healthy Adults
Status: COMPLETED
Conditions: Pneumococcal Vaccines
Interventions: OTHER: Placebo|BIOLOGICAL: SPWCV+Alum 100 mcg|BIOLOGICAL: SPWCV+Alum 600 mcg|BIOLOGICAL: SPWCV+Alum 300 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of the Surgical Mask on the Patient-nurse Relation in Primary Care
Status: UNKNOWN
Conditions: Satisfaction, Personal
Interventions: DEVICE: Mask|PROCEDURE: Routine wound treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Angelica Sinensis for the Treatment of Hot Flashes in Men Undergoing LHRH Therapy for Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Angelica Sinensis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prostatic Resection Cavity Stone Post Transurethral Resection of the Prostate (TURP). A Rare Case Scenario
Status: COMPLETED
Conditions: Prostate Hyperplasia
Interventions: PROCEDURE: cystoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluates the Safety, Pharmacokinetics, Immunogenicity and Efficacy of QLS31903 in Advanced Solid Tumor Patients
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: QLS31903
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Loco-regional Analgesia Following Placement of Erector Spinae Plane Catheter in Addition to Systemic Analgesia in Patients With Thoracic Trauma
Status: RECRUITING
Conditions: Trauma Abdomen
Interventions: DEVICE: Erector spinae plane catheter group in addition to Systemic Analgesia|DRUG: Systemic Analgesia Only Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Characterize the Safety, Tolerability, and Preliminary Efficacy of CFT1946 as Monotherapy and Combination Therapy in Subjects With BRAF V600 Mutant Solid Tumors
Status: RECRUITING
Conditions: Solid Tumors|Melanoma|NSCLC|CRC|ATC
Interventions: DRUG: CFT1946|DRUG: Trametinib|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Catheter Directed Interventions in Pulmonary Embolism
Status: UNKNOWN
Conditions: Pulmonary Embolism
Interventions: PROCEDURE: catheter directed fragmentation and thrombolysis|DRUG: Streptokinase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: E-mails to Nudge Safer and Better-Informed Prescribing of Risky Drugs
Status: RECRUITING
Conditions: Opioid Prescribing|Prescription Drug Misuse
Interventions: BEHAVIORAL: PDMP Legal Mandate E-mail|BEHAVIORAL: PDMP Clinical Benefit E-mail
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Progesterone to Prevent Preterm Delivery
Status: UNKNOWN
Conditions: Preterm Birth
Interventions: DRUG: Dydrogesterone Oral Tablet|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Time to be Ready to Void: a New Tool to Assess the Time Needed to Perform Micturition in Multiple Sclerosis
Status: COMPLETED
Conditions: Gait Disorders, Neurologic|Urinary Incontinence, Urge|Multiple Sclerosis
Interventions: OTHER: completion of the test created Time to be Ready to Void
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Spherical Aberration and Contrast Sensitivity in IOLs
Status: COMPLETED
Conditions: Cataract|Signs and Symptoms|Pseudophakia|Lens Diseases
Interventions: PROCEDURE: Cataract surgery and intraocular lens implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety of BIIB122 Tablets and if it Can Slow the Worsening of Early-Stage Parkinson's Disease in Participants Between the Ages of 30 and 80
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: BIIB122|DRUG: BIIB122-Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ABC-lung: Atezolizumab, Bevacizumab and Chemotherapy in EGFR-mutant Non-small Cell Lung Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: EGFRmutant Stage IIIB/C or IV Non-squamous NSCLC
Interventions: DRUG: Atezolizumab|DRUG: Bevacizumab|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Zanubrutinib and Tislelizumab in Progressive Lymphoma Post CAR-T
Status: NOT_YET_RECRUITING
Conditions: Large B-cell Lymphoma
Interventions: DRUG: Tislelizumab|DRUG: Zanubrutinib|DRUG: Tislelizumab + Zanubrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic (PK) Study Evaluating Naproxen and Esomeprazole Plasma Levels
Status: COMPLETED
Conditions: Arthritis
Interventions: DRUG: PN 400|DRUG: EC naproxen plus EC esomeprazole|DRUG: EC naproxen|DRUG: EC esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Two Omeprazole-Containing Products for Relief of Frequent Heartburn (MK-0764A-036)
Status: COMPLETED
Conditions: Heartburn
Interventions: DRUG: Omeprazole 20 mg + Sodium Bicarbonate 1100 mg|DRUG: Omeprazole 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Combined Neuro-vestibular-ocular Exercises and Myofascial Release on Proprioception and Performance in Soccer Players With Chronic Ankle Instability
Status: NOT_YET_RECRUITING
Conditions: Ankle Inversion Sprain|Ankle Injuries
Interventions: OTHER: Neuro-vestibular-ocular group|OTHER: Myofascial Release group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chest Wall Oscillation for Asthma and COPD Exacerbations Trial (COAT)
Status: COMPLETED
Conditions: Asthma|Chronic Obstructive Pulmonary Disease (COPD)|Undifferentiated Asthma/COPD
Interventions: DEVICE: High Frequency Chest Wall Oscillator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Tocilizumab in Moderate to Severe COVID-19 With Inflammatory Markers
Status: TERMINATED
Conditions: COVID|SARS Pneumonia|Cytokine Release Syndrome
Interventions: DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NHF vs NIV in Patients With Acute Exacerbation of COPD
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease|Respiratory Failure|Acute Exacerbation Copd
Interventions: DEVICE: Nasal High Flow|DEVICE: Non-Invasive Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ridge Splitting With Simultaneous Implant Placement Using i-PRF
Status: COMPLETED
Conditions: Ridge Splitting|i-PRF|Dental Implant
Interventions: PROCEDURE: Immediate implant placement and alveolar ridge splitting with GBR and i-PRF|PROCEDURE: Immediate implant placement and alveolar ridge splitting with GBR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of MD-7246 to Treat Abdominal Pain in Patients With Diarrhea-predominant Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Diarrhea (IBS-D)
Interventions: DRUG: MD-7246|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Green Tea Extracts on Gastric Mucosal Protection
Status: COMPLETED
Conditions: Functional Dyspepsia
Interventions: DIETARY_SUPPLEMENT: Green tea combined extracts group|DIETARY_SUPPLEMENT: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bilateral Superficial Cervical Block for Thyroidectomy
Status: UNKNOWN
Conditions: Cervical Pain
Interventions: DRUG: 0.9% saline|DRUG: Ropivacaine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Function of Beta Cell Allografts in Non-uremic Type 1 Diabetic Patients
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: ATG-MMF-TAC|DRUG: ATG-Rituximab-MMF-TAC|DRUG: ATG-basilixumab-MMF-TAC|PROCEDURE: omentum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioresorbable Vascular Scaffolds Versus Stents in Patients With Chronic Total Occlusion
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Everolimus-eluting bioresorbable vascular scaffold|DEVICE: Everolimus-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Electrical Nerve Stimulation in Relation to Central Sensitization in Osteoarthritis of the Knee
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Transcutaneous electric nerve stimulation|DEVICE: sham transcutaneous electrical nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of a Keratoconus Detection Algorithm by Deep Learning Analysis and Its Validation on Eyestar Images
Status: UNKNOWN
Conditions: Keratoconus|Eye Diseases|Cataract|Corneal Ectasia
Interventions: DEVICE: Corneal tomography with Eyestar 900|DEVICE: Corneal tomography with Pentacam|DEVICE: Biometry with IOL-Master|OTHER: retrospective analysis, no intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Helmet Continuous Positive Airway Pressure Support for Severe Bronchiolitis in PICUs
Status: TERMINATED
Conditions: Critically Ill Severe Bronchiolitis
Interventions: DEVICE: 10 cmH2O peep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase I Clinical Study of MBS301 in Treatment of HER2 Positive Recurrent or Metastatic Malignant Solid Tumor
Status: RECRUITING
Conditions: HER2-positive Recurrent or Metastatic Malignant Solid Tumor
Interventions: DRUG: Recombinant Humanized Bispecific Monoclonal Antibody MBS301
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Dabigatran With or Without Clarithromycin in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Dabigatran etexilate|DRUG: Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Ashwagandha on Perceived Stress, Sleep and Food Cravings in College Students
Status: COMPLETED
Conditions: Stress|Sleep|Craving|Well Being
Interventions: DIETARY_SUPPLEMENT: Ashwagandha|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telehealth Psychotherapy for Anxiety in Persons With Cognitive Impairment
Status: UNKNOWN
Conditions: Psychotherapy|Cognitive Impairment|Anxiety
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Imatinib Cetuximab Combo for H & N Cancer
Status: RECRUITING
Conditions: Head and Neck Cancer|Squamous Cell Carcinoma of Head and Neck
Interventions: DRUG: Cetuximab|DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Non-Small Cell Lung Cancer (NSCLC) Stages IIIB/IV
Status: TERMINATED
Conditions: Non-small-cell Lung Cancer (NSCLC) Stage IIIb/IV
Interventions: BIOLOGICAL: Recombinant Human rEGF-P64K/Montanide Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serial Endoscopic Surveillance & Direct Topical Antibiotics to Define the Role of Microbes in Anastomotic Healing
Status: WITHDRAWN
Conditions: Anastomotic Leak|Rectal Cancer
Interventions: DRUG: Cipro, metronidazole, neomycin combo|PROCEDURE: Serial Endoscopic Surveillance|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Immunogenicity, and Immune Persistence Study of an Inactivated Hepatitis A Vaccine
Status: COMPLETED
Conditions: Hepatitis A
Interventions: BIOLOGICAL: Healive® Lot 1|BIOLOGICAL: Healive® Lot 2|BIOLOGICAL: Healive® Lot 3|BIOLOGICAL: Havrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of Risdiplam (RO7034067) in Type 2 and 3 Spinal Muscular Atrophy (SMA) Participants
Status: COMPLETED
Conditions: Muscular Atrophy, Spinal
Interventions: DRUG: Placebo|DRUG: Risdiplam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Arixtra vs. Lovenox to Prevent Blood Clots in Medically Ill Patients
Status: TERMINATED
Conditions: Venous Thrombosis
Interventions: DRUG: Arixtra (Fondaparinox) 2.5 mg SC Daily|DRUG: Lovenox 40mg SC Daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TSN222 in Subjects With Advanced Solid Tumors or Lymphomas
Status: RECRUITING
Conditions: Has a Pathologically Documented Unresectable Locally Advanced or Metastatic Solid Tumor or Lymphoma
Interventions: DRUG: Phase I dose escalation|DRUG: Phase II-HNSCC|DRUG: Phase II-Advanced melanoma|DRUG: Phase II-solid tumors or lymphomas
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Accuracy of Rapid Tests for Group A Beta Hemolytic Streptococci in Out-patients With Sore Throat
Status: COMPLETED
Conditions: Pharyngitis
Interventions: DEVICE: Sofia|DEVICE: QuickVue|DEVICE: Throat swab culture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Nutritional Management on RIOM in Patients With Advanced Head and Neck Cancer
Status: NOT_YET_RECRUITING
Conditions: Head and Neck Cancer|Nutrition Related Cancer|Radiation-Induced Mucositis
Interventions: BEHAVIORAL: nutrition management
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of PEEP=5cmH2O vs PEEP=0cmH2O PSV Strategies During SBT on Successful Disconnection From Mechanical Ventilation
Status: UNKNOWN
Conditions: Respiration, Artificial
Interventions: PROCEDURE: PEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison Between Palonosetron Versus Granisetron as PONV Prophylaxis in Scoliotic Patients Undergoing Spine Surgery
Status: NOT_YET_RECRUITING
Conditions: Postoperative Nausea and Vomiting|Scoliosis
Interventions: DRUG: Palonosetron (Group P)|DRUG: Granisetron (Group G)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Azithromycin in Individual Patients With Serious Nontuberculous Mycobacterial Disease Who Are Failing or Intolerant of Other Available Therapy
Status: COMPLETED
Conditions: Mycobacterium Avium-Intracellulare Infection|HIV Infections|Tuberculosis, Mycobacterium Infection
Interventions: DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Azacytidine for the Treatment of Myelodysplastic Syndromes/Acute Myeloid Leukemia (MDS/AML) With High Risk (Chromosome 7 and or Complex) Cytogenetic Abnormalities
Status: COMPLETED
Conditions: Myelodysplastic Syndromes|Leukemia, Myeloid, Acute
Interventions: DRUG: 5 azacytidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors
Status: COMPLETED
Conditions: RET-altered Non Small Cell Lung Cancer|Medullary Thyroid Cancer|RET-altered Papillary Thyroid Cancer|RET-altered Colon Cancer|RET-altered Solid Tumors|Lung Neoplasm|Carcinoma, Non-Small-Cell Lung|Thyroid Diseases|Thyroid Neoplasm|Thyroid Cancer, Papillary|Carcinoma, Neuroendocrine|Respiratory Tract Neoplasms|Thoracic Neoplasms|Neoplasms by Site|Neoplasms|Lung Diseases|Respiratory Tract Disease|Carcinoma, Bronchogenic|Bronchial Neoplasms|Endocrine System Diseases|Endocrine Gland Neoplasm|Head and Neck Neoplasms|Adenocarcinoma, Papillary|Adenocarcinoma|Carcinoma|Neoplasms, Glandular and Epithelial|Neoplasms by Histologic Type|Neuroendocrine Tumors|Neuroectodermal Tumors|Neoplasms, Germ Cell and Embryonal|Neoplasms, Nerve Tissue|Colonic Neoplasms|Colorectal Neoplasms|Intestinal Neoplasms|Gastrointestinal Neoplasms|Digestive System Neoplasm|Digestive System Disease|Gastrointestinal Disease|Colonic Diseases|Intestinal Disease
Interventions: DRUG: pralsetinib (BLU-667)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Shockwave Therapy for Diabetic Foot Wounds
Status: UNKNOWN
Conditions: Diabetic Foot|Wound
Interventions: DEVICE: Extracorporeal shockwave therapy|OTHER: Standard Wound Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 99mTc-P137 SPECT/CT in Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: SPECT/CT imaging with 99mTc-P137 nuclide probe
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase 1 Study of the Effects of Combining Topical FDA-approved Drugs on Age-related Pathways on the Skin of Healthy Volunteers
Status: COMPLETED
Conditions: Aging
Interventions: DRUG: Sirolimus|DRUG: Metformin|DRUG: Diclofenac
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial of XP (Capecitabine/CDDP) Simvastatin in Advanced Gastric Cancer Patients
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: Simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of DSP-Visulex for the Treatment of Anterior Uveitis
Status: COMPLETED
Conditions: Non-Infectious Anterior Uveitis
Interventions: DRUG: 8% Dexamethasone Sodium Phosphate - Visulex|DRUG: 15% Dexamethasone Sodium Phosphate - Visulex|DRUG: Prednisolone Acetate (1%) Eye Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cerebral Blood Flow During Hemodialysis
Status: COMPLETED
Conditions: Haemodialysis-induced Symptom
Interventions: OTHER: [15O]H2O PET-CT scan|OTHER: NIRS (Invos)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Lidocaine Injection on Stellate Ganglion in Pediatric Patients With Autism Spectrum Disorder
Status: NOT_YET_RECRUITING
Conditions: Autistic Disorder
Interventions: BEHAVIORAL: Routine therapy|PROCEDURE: Injection|DRUG: Lidocaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of EMS and Strengthening Exercises on Pain, Fatigue and Physical Performance in Motocross Athletes
Status: COMPLETED
Conditions: Sports Injury
Interventions: DEVICE: Electromyostimulation|OTHER: Strengthening exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Natural Experiment: "Gentle Nudge" Intervention, Eliminating Phone Call Requirement
Status: COMPLETED
Conditions: Back Pain|X-rays|MRI|CT Scan|Clinical Decision Support Tool
Interventions: BEHAVIORAL: Gentle Nudge|BEHAVIORAL: Usual Standard Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Amount of Root Resorption of Maxillary Anteriors After en Masse Versus Two Step Space Closure
Status: ACTIVE_NOT_RECRUITING
Conditions: Root Resorption
Interventions: PROCEDURE: retraction method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 2 Trial of Apatinib Mesylate in Locally Advanced/Metastatic Differentiated Thyroid Carcinoma
Status: UNKNOWN
Conditions: Differentiated Thyroid Carcinoma
Interventions: DRUG: Apatinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT