pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Clinical Study of Vitamin B5 in Adjuvant Treatment of IBD
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases
Interventions: DRUG: Vitamin B5 Tablets|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Geneferm Nattokinase
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DRUG: Nattokinase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Stereotactic Ablative Radiotherapy for Oligo-Progressive Non Small Cell Lung Cancer
Status: RECRUITING
Conditions: Lung Cancer Metastatic
Interventions: RADIATION: SABR|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Changing Physiological Conditions on Myogenic Oscillations: Pilot Study
Status: COMPLETED
Conditions: Vascular Diseases
Interventions: DRUG: Phenylephrine|DRUG: Dexmedetomidine|DRUG: Clevidipine|OTHER: tetanic stimulus|OTHER: Increased venous pressure|DRUG: Calcium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Oxycodone Versus Intravenous Morphine for Postoperative Analgesia After Hip Surgery
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Hip
Interventions: DRUG: Standard Care morphine hydrochloride|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Family-based Approach to Promotion of Health - FAMILIA (Project 2)
Status: COMPLETED
Conditions: Promoting Cardiovascular Health in Adults|Lifestyle Intervention|Atherosclerosis
Interventions: BEHAVIORAL: Intensive Individual Intervention Program|BEHAVIORAL: Peer-To-Peer Program Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Exercises on Diaphragmatic Excursion in Postmenopausal Kyphotic Women
Status: COMPLETED
Conditions: Kyphosis Postural Thoracic
Interventions: OTHER: corrective exercises|OTHER: resisted diaphragmatic breathing exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Defibrotide for the Treatment of Severe Hepatic Veno-Occlusive Disease in Hematopoetic Stem Cell Transplant Patients
Status: COMPLETED
Conditions: Severe Hepatic Veno-Occlusive Disease
Interventions: DRUG: Defibrotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Recombinant AAV2/6 Human Factor 8 Gene Therapy SB-525 (PF-07055480) in Subjects With Severe Hemophilia A
Status: COMPLETED
Conditions: Hemophilia A
Interventions: BIOLOGICAL: SB-525 (PF-07055480)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Salmeterol on Brain-Derived Neurotrophic Factor (BDNF) Concentrations in Asthma
Status: COMPLETED
Conditions: Allergic Asthma
Interventions: DRUG: Salmeterol and Salmeterol / Fluticasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intranasal Retinoic Acid Treatment for Patients With OlfactoryLOSS: A RANDOMIZED CONTROLLED TRIAL
Status: UNKNOWN
Conditions: Olfactory Disorder
Interventions: DIETARY_SUPPLEMENT: Vitamin A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neural Mechanisms of Immersive Virtual Reality in Chronic Pain
Status: RECRUITING
Conditions: Pain|Virtual Reality|Placebo|Temporomandibular Disorder
Interventions: BEHAVIORAL: Active Virtual Reality|BEHAVIORAL: sham Virtual Reality|OTHER: No Intervention|DRUG: Naloxone|OTHER: Saline|OTHER: Natural history
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of a Vibration System on Pain Reduction During Injection of Local Dental Anaesthesia in Children
Status: COMPLETED
Conditions: Local Anaesthetic|Dental Anxiety
Interventions: DEVICE: Adminstration Technique using Buzzy external distractor|DRUG: 2% Lidocaine with 1:50,000 epinephrine|DRUG: Topical Anesthetic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Synthetic Human Secretin (ChiRhoStim®) Administered Intravenously to Stimulate Exocrine Pancreas Fluid Secretion for Collection Via Endoscope and Laboratory Analysis of DNA Markers
Status: COMPLETED
Conditions: Pancreatic Disease
Interventions: DRUG: ChiRhoStim|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: PD-1 Antibody Expressing CAR T Cells for Mesothelin Positive Advanced Malignancies
Status: UNKNOWN
Conditions: Solid Tumor, Adult|Advanced Cancer
Interventions: BIOLOGICAL: PD-1 antibody expressing mesothelin specific CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Entinostat and Sorafenib Tosylate in Treating Patients With Advanced or Metastatic Solid Tumors or Refractory or Relapsed Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Blastic Phase Chronic Myelogenous Leukemia|Recurrent Adult Acute Myeloid Leukemia|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: entinostat|DRUG: sorafenib tosylate|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Triathlon - A New Total Knee Prosthesis System - RSA Triathlon Cruciate Retaining - Cemented vs. Uncemented
Status: ACTIVE_NOT_RECRUITING
Conditions: Arthroplasty, Replacement, Knee
Interventions: DEVICE: Triathlon CR cemented|DEVICE: Triathlon CR uncemented
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of Recombinant Human Hepatocyte Growth Factor in Fulminant Hepatic Failure
Status: UNKNOWN
Conditions: Liver Failure, Acute
Interventions: DRUG: Recombinant human hepatocyte growth factor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of KH631 Gene Therapy in Participants With Neovascular Age-related Macular Degeneration
Status: RECRUITING
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: KH631
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Rapamycin Therapy to Alleviate Cutaneous Manifestations of Tuberous Sclerosis Complex (TSC) and Neurofibromatosis I (NF1)
Status: COMPLETED
Conditions: Tuberous Sclerosis|Neurofibromatoses|Angiofibroma|Neurofibroma
Interventions: DRUG: Skincerity|DRUG: Skincerity plus sirolimus/rapamycin|DRUG: Skinercity plus sirolimus/rapamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Neosil on Chronic Effluvium
Status: COMPLETED
Conditions: Chronic Telogen Effluvium
Interventions: DRUG: Neosil complete|DRUG: Pantogar|DRUG: Neosil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of BAFF CAR-T Cells (LMY-920) for Non-Hodgkin Lymphoma
Status: RECRUITING
Conditions: Lymphoma, Non-Hodgkin Lymphoma, B-Cell
Interventions: DRUG: BAFF CAR-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zalutumumab in Combination With Chemotherapy and Radiotherapy in Head and Neck Cancer
Status: TERMINATED
Conditions: Head and Neck Cancer|Squamous Cell Cancer
Interventions: DRUG: zalutumumab|DRUG: cisplatin|PROCEDURE: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Grapiprant and Eribulin for the Treatment of Metastatic Inflammatory Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Inflammatory Carcinoma|Recurrent Breast Inflammatory Carcinoma|Stage IV Breast Inflammatory Carcinoma
Interventions: DRUG: Eribulin Mesylate|DRUG: Grapiprant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Mesenchymal Stem Cells in the Treatment of Pneumonia of Coronavirus Disease 2019
Status: UNKNOWN
Conditions: COVID-19 Pneumonia
Interventions: DRUG: Oseltamivir|DRUG: hormones|DEVICE: oxygen therapy|PROCEDURE: mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zoledronic Acid in Acute Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: DRUG: Zoledronic acid|DRUG: normal saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Living Successfully With Chronic Eye Diseases
Status: UNKNOWN
Conditions: Chronic Diseases|Low Vision|Diabetic Retinopathy|Glaucoma|Age-related Macular Degeneration
Interventions: BEHAVIORAL: Low Vision Self-Management Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect Of Education Given According to Meleıs' Transitional Theory to Patients With Pacemaker
Status: COMPLETED
Conditions: Educational Activities
Interventions: OTHER: Education According to Meleis' Transitional Theory to Patients With Pacemaker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Early Detection of Epstein-Barr Virus Related Disease.
Status: COMPLETED
Conditions: Post-transplant Lymphoproliferative Disorder|Mononucleosis|Epstein-Barr Virus Infections|Epstein-Barr Virus Related Malignancy|Epstein-Barr Viraemia|Epstein-Barr Virus-Related Hodgkin Lymphoma|Epstein-Barr Virus-Related Non-Hodgkin Lymphoma|Hemophagocytic Lymphohistiocytoses|Hemophagocytosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Efficacy of Optometric Rehabilitation on Visual Cognitive Deficits in Children
Status: UNKNOWN
Conditions: Visual Cognitive Deficits
Interventions: OTHER: Optometric therapy during 6 months|OTHER: Optometric therapy during 12 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for Eye Diseases
Status: RECRUITING
Conditions: Eye Diseases|Retinitis Pigmentosa|Glaucoma|Diabetic Retinopathy|Macular Degeneration|Traumatic Optic Neuropathy|Optic Atrophy
Interventions: BIOLOGICAL: AlloRx
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Vagus Nerve Stimulation in Acute Ischemic Stroke
Status: ACTIVE_NOT_RECRUITING
Conditions: Ischemic Stroke
Interventions: DEVICE: non-invasive Vagus Nerve Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Nonessential Amino Acid Restriction (NEAAR) Medical Food With Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer (LARC)
Status: RECRUITING
Conditions: Rectal Cancer
Interventions: OTHER: NEAAR Medical Food
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety Study of Levocetirizine Dihydrochloride Oral Liquid Formulation in Children Aged 1 to Less Than 6 Years Suffering From Allergic Rhinitis or Chronic Urticaria of Unknown Origin
Status: COMPLETED
Conditions: Allergic Rhinitis|Chronic Urticaria
Interventions: DRUG: Levocetirizine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Learning and Improving Alzheimer's Patient-Caregiver Relationships Via Smart Healthcare Technology
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer Disease|Caregiver Stress Syndrome
Interventions: BEHAVIORAL: Mood Monitoring and Behavioral Recommendation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: PK/PD Study With G-Pump (Glucagon Infusion) in T1DM Patients
Status: COMPLETED
Conditions: Hypoglycemia
Interventions: DRUG: Novo Nordisk GlucaGen®|DRUG: G-Pump™ (glucagon infusion)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tricuspid Regurgitation Study
Status: COMPLETED
Conditions: Tricuspid Regurgitation|Right Ventricular Dysfunction|Left Ventricular Dysfunction
Interventions: OTHER: Echo|OTHER: Echo|OTHER: Echo|OTHER: Echo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Gut Microbiota-targeted Diatery Intervention Among People Living With HIV
Status: NOT_YET_RECRUITING
Conditions: HIV|Atherosclerosis|Diet, Healthy
Interventions: DIETARY_SUPPLEMENT: gut microbiota-targeted dietary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Reduced-Intensity Busulfan and Fludarabine With or Without Antithymocyte Globulin Followed by Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Other Disease
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: anti-thymocyte globulin|BIOLOGICAL: sargramostim|BIOLOGICAL: therapeutic allogeneic lymphocytes|DRUG: busulfan|DRUG: fludarabine phosphate|DRUG: methotrexate|DRUG: tacrolimus|PROCEDURE: nonmyeloablative allogeneic hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BTZ-043 - Multiple Ascending Dose (MAD) to Evaluate Safety, Tolerability and Early Bactericidal Activity (EBA)
Status: COMPLETED
Conditions: Pulmonary Tuberculoses|Other Specified Pulmonary Tuberculosis
Interventions: DRUG: BTZ-043|DRUG: Rifafour e-275®|DRUG: Probe Drug Cocktail|DRUG: Dolutegravir 50mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Usefulness of the Medissimo Nurse Application for Supporting Medication Compliance in Elderly People With Chronic Polypathologies
Status: NOT_YET_RECRUITING
Conditions: Digital Application|Elderly Person|Chronic Disease|Polypathology|Medication Compliance
Interventions: OTHER: 100 Patients|OTHER: Healthcare professionals (20 doctors, 20 pharmacists and 20 nurses)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Analgesic Effect of Ultrasound Guided Errector Spinae Plane Block Versus Ultrasound Guided Caudal Block in Pediatric Open Renal Surgeries.
Status: COMPLETED
Conditions: Analgesia , Open Renal Surgeries
Interventions: OTHER: ultrasound guided blocks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Extended Treatment Study of MT-3995 in Patients With Diabetic Nephropathy
Status: COMPLETED
Conditions: Diabetic Nephropathy
Interventions: DRUG: MT-3995 Low|DRUG: MT-3995 Middle|DRUG: MT-3995 High
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Spinal Cord Injury Patients for Neurogenic Bladder: Anticholinergic Agent vs. Mirabegron
Status: COMPLETED
Conditions: Spinal Cord Injuries|Neurogenic Bladder|Cognitive Change
Interventions: DRUG: Mirabegron
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimization of Sepsis Therapy Based on Patient-specific Digital Precision Diagnostics
Status: UNKNOWN
Conditions: Sepsis|Septic Shock
Interventions: DIAGNOSTIC_TEST: Standard diagnostics|DIAGNOSTIC_TEST: Next Generation Sequencing (NGS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Continuous Noninvasive Arterial Pressure Measurement on Anaesthesia
Status: COMPLETED
Conditions: Blood Pressure Stability in General Anaesthesia
Interventions: DEVICE: continuous noninvasive blood pressure monitoring ClearSight-Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Antimalarials in Uncomplicated Malaria
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Sulfadoxine-pyrimethamine|DRUG: Artesunate plus sulfadoxine-pyrimethamine|DRUG: Artemether-lumefantrine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess EDP-938 for the Treatment of Acute Upper Respiratory Tract Infection With Respiratory Syncytial Virus in Adult Subjects
Status: COMPLETED
Conditions: Respiratory Syncytial Virus
Interventions: DRUG: EDP-938|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison Study of Treatments Given to Patients With Concurrent Eating Disorder and Personality Disorder.
Status: COMPLETED
Conditions: Eating Disorder|Anorexia Nervosa|Bulimia Nervosa|Personality Disorder
Interventions: BEHAVIORAL: inpatient treatment|BEHAVIORAL: outpatient treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of V0018 1.5 mg Effect on Craving
Status: COMPLETED
Conditions: Smoking
Interventions: DRUG: V0018|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Ex Vivo Expansion of Human Umbilical Cord Blood Stem and Progenitor Cells
Status: TERMINATED
Conditions: Acute Leukemia|Chronic Leukemia|Myelodysplastic Syndrome|Lymphoma|Myeloma
Interventions: OTHER: Ex vivo expanded cord blood cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Glucocorticoids on Craving During Detoxification Treatment of Heroin and/or Stimulants
Status: TERMINATED
Conditions: Opioid Dependence|Cocaine Dependence
Interventions: DRUG: Prednisolone|DRUG: Placebo (for Prednisolone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immunogenicity and Safety of the Concomitant Administration of a Tdap Vaccine and Meningococcal ACWY Conjugate Vaccine in Healthy Subjects Aged 11-25 Years
Status: COMPLETED
Conditions: Meningococcal Disease|Meningococcal Meningitis
Interventions: BIOLOGICAL: Meningococcal ACWY conjugate vaccine (MenACWY-CRM)|BIOLOGICAL: Combined tetanus, reduced diphtheria and acellular pertussis vaccine (Tdap)|BIOLOGICAL: saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I/II Study to Assess the Safety and Activity of Enhanced TCR Transduced Autologous T Cells in Metastatic Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: GENETIC: Autologous genetically modified T cells, NY-ESO-1ᶜ²⁵⁹T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVIDAR - Arrhythmias in COVID-19
Status: UNKNOWN
Conditions: COVID|Arrhythmia|Torsades de Pointe Caused by Drug|Qt Interval, Variation in|Atrioventricular Block|Atrial Fibrillation|Bradyarrhythmia|Ventricular Arrythmia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery
Status: RECRUITING
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: pantoprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Proof of Concept Trial of Cannabis Derivatives in Neuropathic Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetic Neuropathic Pain
Interventions: DRUG: THC (Dronabinol)|DRUG: CBD (Epidolex)|DRUG: THC + CBD (Nabiximols)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Insulin for Improving Cognitive Function in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting|Multiple Sclerosis, Secondary Progressive|Multiple Sclerosis, Primary Progressive
Interventions: DRUG: Insulin|DRUG: Placebo (Sterile diluent)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Effect of a Novel Surface Roughness Treatment on Dental Implants on Integration Success
Status: COMPLETED
Conditions: Partial Edentulism|Tooth Disease
Interventions: DEVICE: Osseotite Certain Tapered Group A|DEVICE: Osseotite Certain Tapered Group B|DEVICE: Osseotite Certain Tapered Group C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Decision Support for PrEP
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections|Preexposure Prophylaxis (PrEP)
Interventions: OTHER: Standard of care|OTHER: Clinical decision support for PrEP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With IDH1 or IDH2 Mutations
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome (MDS)|Chronic Myelomonocytic Leukemia (CMML)|Myeloproliferative Neoplasms (MPNs)
Interventions: DRUG: LY3410738|DRUG: Venetoclax|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis
Status: RECRUITING
Conditions: Pain|Pain Syndrome|Pain, Chronic|Chronic Pain|Chronic Pain Syndrome|Neuropathic Pain|Central Neuropathic Pain|Paraplegia|Multiple Sclerosis|Stroke|Phantom Limb Syndrome With Pain|Phantom Pain|Traumatic Brain Injury
Interventions: DRUG: Adezunap (AP707)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Daptomycin for the Treatment of Complicated Skin and Skin-structure Infections
Status: TERMINATED
Conditions: Staphylococcal Skin Infections
Interventions: DRUG: Daptomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Therapy (Provigil + Avonex) to Treat Cognitive Problems in MS
Status: UNKNOWN
Conditions: Relapsing-Remitting Multiple Sclerosis
Interventions: DRUG: Provigil (modafinil)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pembrolizumab Plus Investigational Agents in Combination With Chemotherapy as First-Line Treatment in Extensive-Stage Small Cell Lung Cancer (ES-SCLC) (MK-3475-B99/ KEYNOTE-B99)
Status: ACTIVE_NOT_RECRUITING
Conditions: Small Cell Lung Cancer
Interventions: BIOLOGICAL: Pembrolizumab|BIOLOGICAL: MK-4830|BIOLOGICAL: Boserolimab|DRUG: Lenvatinib|DRUG: Etoposide|DRUG: Cisplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sofosbuvir/Velpatasvir Fixed-Dose Combination in Adults With Chronic HCV Infection and Child-Pugh Class B Cirrhosis
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: SOF/VEL|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: vINCRISTINE|DRUG: Dexamethasone|DRUG: Methotrexate|DRUG: Cytosine arabinoside
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Split-body, Single-blinded Clinical Trial of NB-UVB Treatment for Vitiligo
Status: TERMINATED
Conditions: Vitiligo|Pigmentation|Dyschromia
Interventions: DEVICE: narrow-band ultraviolet B phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Convenience, Tolerability, and Safety of Change in the Administration of Rivastigmine From Capsules to a Transdermal Patch in Patients With Mild to Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Rivastigmine patch (4.6 mg/day switch to 9.5 mg/day)|DRUG: Rivastigmine patch (9.5 mg/day)|DRUG: Rivastigmine capsules (6 mg to 12 mg/day)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LeucoPatch™ Study A Multicenter Study on the Effect of LeucoPatch™ in Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot Ulcers
Interventions: DEVICE: LeucoPatch treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radicle Relaxation 24: A Study of Health and Wellness Products on Stress and Related Health Outcomes
Status: RECRUITING
Conditions: Stress
Interventions: DIETARY_SUPPLEMENT: Placebo Control Form 1|DIETARY_SUPPLEMENT: Relaxation Active Study Product 1.1|DIETARY_SUPPLEMENT: Placebo Control Form 2|DIETARY_SUPPLEMENT: Relaxation Active Study Product 2.1|DIETARY_SUPPLEMENT: Placebo Control Form 3|DIETARY_SUPPLEMENT: Relaxation Active Study Product 3.1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Possible Association of Intestinal Helminths and Protozoa With Colorectal Cancer Pathogenesis
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer|Colorectal Cancer Metastatic|Intestinal Parasite|Protozoan Infections
Interventions: DIAGNOSTIC_TEST: Parasitological examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Etoricoxib vs Aceclofenac in the Treatment of Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Etoricoxib|DRUG: Aceclofenac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study With Imlifidase in Anti-GBM Disease
Status: RECRUITING
Conditions: Anti-Glomerular Basement Membrane Disease|Anti-Glomerular Basement Membrane Antibody Disease|Goodpasture Syndrome|Good Pasture Syndrome
Interventions: DRUG: Imlifidase|PROCEDURE: Plasma exchange (PLEX)|DRUG: Cyclophosphamide (CYC)|DRUG: Glucocorticoids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bupropion in Helping Adults Stop Smoking
Status: COMPLETED
Conditions: Bladder Cancer|Cervical Cancer|Esophageal Cancer|Gastric Cancer|Head and Neck Cancer|Kidney Cancer|Leukemia|Liver Cancer|Lung Cancer|Pancreatic Cancer|Tobacco Use Disorder
Interventions: DRUG: bupropion hydrochloride|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dose Finding Study of Single Dose GHB11L1 in Healthy Adults
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: GHB11L1|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nab-Pac+Cis+Gem in Pts w Previously Untreated Metastatic PDA
Status: COMPLETED
Conditions: Stage IV Pancreatic Cancer
Interventions: DRUG: nab-paclitaxel|DRUG: Cisplatin|DRUG: gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Flurbiprofen Lozenge vs Strepfen
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Flurbiprofen Test 8.75 MG|DRUG: Flurbiprofen Reference 8.75 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Biphasic Insulin Aspart 70/30 vs. Exenatide in Type 2 Diabetes Patients Not Reaching Blood Glucose Targets on Metformin and a Sulfonylurea.
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart|DRUG: exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, Tolerability, and Pharmacokinetics of Indacaterol Salts in Patients With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Indacaterol maleate 400 μg|DRUG: Indacaterol acetate 400 μg|DRUG: Indacaterol xinafoate 400 μg|DRUG: Placebo to indacaterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery
Status: COMPLETED
Conditions: Coronary Artery Disease|Mitral Valve Regurgitation
Interventions: DRUG: Etomidate|DRUG: Propofol|DRUG: Hydrocortisone|DRUG: NaCl 0.9%|OTHER: Tetracosactin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nerve Protection Evaluation: Revision Cubital Tunnel Syndrome Decompression
Status: RECRUITING
Conditions: Recurrent Cubital Tunnel Syndrome|Recalcitrant Cubital Tunnel Syndrome
Interventions: DEVICE: Axoguard HA+ Nerve Protector™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DOuble-BAlloon Versus PROstaglandin E2 for Cervical Ripening in Low Risk Pregnancies
Status: RECRUITING
Conditions: Induction of Labor
Interventions: DEVICE: Double-balloon catheter (UTAH CVX-RIPE) for cervical ripening|DRUG: Dinoprostone 10mg (Propess)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketone Ester and Acute Salt (KEAS) in Young Adults
Status: RECRUITING
Conditions: Salt; Excess|Hypertension
Interventions: DIETARY_SUPPLEMENT: No Salt, No β-OHB|DIETARY_SUPPLEMENT: High Salt, No β-OHB|DIETARY_SUPPLEMENT: High Salt, High β-OHB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Effect of Injectable Neucardin on Cardiac Function and Reversal Ventricular Remodeling in Patients With Chronic Systolic Heart Failure
Status: RECRUITING
Conditions: Chronic Systolic Heart Failure
Interventions: DRUG: Neucardin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Drug-Drug Interaction Study to Examine the Impact of Itraconazole and Cyclosporine on PF-07081532 Pharmacokinetics in Overweight or Obese Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-07081532|DEVICE: Cyclosporine|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Motexafin Gadolinium for the Treatment of Chronic Lymphocytic Leukemia (CLL)
Status: TERMINATED
Conditions: Leukemia|Leukemia, Lymphocytic, Chronic
Interventions: DRUG: Motexafin gadolinium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biweekly Gemcitabine-Oxaliplatin and Dexamethasone for Relapsed/Refractory Malignant Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: DRUG: GemDOx
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cryotherapy in Treating Patients With Primary Lung Cancer or Lung Metastases That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Lung Cancer|Metastatic Cancer
Interventions: PROCEDURE: cryosurgery|PROCEDURE: positron emission tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The S.L.I.M.M.S. Procedure for Severe Clinical Obesity
Status: UNKNOWN
Conditions: Morbid Obesity|Metabolic Syndrome|Type2 Diabetes|Insulin Resistance
Interventions: PROCEDURE: S.L.I.M.M.S. Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes of Clareon Vivity Intraocular Lens With Mini-Monovision Approach
Status: RECRUITING
Conditions: Aphakia, Postcataract
Interventions: DEVICE: Clareon Vivity and Clareon Vivity Toric IOLs targeted for mini-monovision with dominant eye set at emmetropia and non-dominant eye at -0.50.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulsed Field Ablation to Irreversibly Electroporate Tissue and Treat AF
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Medtronic PulseSelect Pulsed Field Ablation (PFA) System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Observation on the Treatment of Motor and Sensory Dysfunction After Stroke With Ruyizhenbao Pill
Status: UNKNOWN
Conditions: Post-stroke Patients With Motor and Sensory Dysfunction
Interventions: DRUG: Ruyizhenbao Pill|DRUG: Placebo of Ruyizhenbao Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral vs. Intravenous TXA Study Proposal: TJA
Status: COMPLETED
Conditions: Blood Loss After Primary Total Joint Arthroplasty|Need for Blood Transfusion After Total Joint Arthroplasty
Interventions: DRUG: Oral Tranexamic Acid|DRUG: Intravenous Tranexamic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Atazanavir Versus Lopinavir/Ritonavir (LPV/RTV) in Patients Who Have Not Had Success With Protease Inhibitor-Containing HAART Regimen(s)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Atazanavir|DRUG: Lopinavir/Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transthoracic Echocardiography of the Superior Vena Cava in Intensive Care Units (ICU) Intubated Patients
Status: UNKNOWN
Conditions: Intubated Patients|Admission in Intensive Care Unit
Interventions: OTHER: Passive leg raising (PLR)|DEVICE: Echo-Doppler measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Trial of Recombinant Hepatitis B Vaccine (Hansenula Polymorpha, 10μg)
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: One dose of investigational vaccine|BIOLOGICAL: One dose of control vaccine|BIOLOGICAL: Three doses of investigational vaccine|BIOLOGICAL: Three doses of control vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Physician Knowledge of Safety and Safe Use Information for Aflibercept in Canada
Status: COMPLETED
Conditions: Age-related Macular Degeneration (AMD)|Central Retinal Vein Occlusion (CRVO)|Diabetic Macular Edema (DME)
Interventions: DRUG: Eylea (Aflibercept, VEGF Trap-Eye, BAY86-5321)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination of Psychosocial Intervention and Slow Prosecutions for the Treatment of Methamphetamine Abuse/Dependence
Status: UNKNOWN
Conditions: Amphetamine Abuse|Amphetamine Dependence|Methamphetamine Abuse|Methamphetamine Dependence
Interventions: BEHAVIORAL: Psychosocial intervention|BEHAVIORAL: Telephone reminding
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Food Study of Verapamil HCl Extended-Release Capsules 300 mg and Verelan® PM Extended-Release Capsules 300 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Verapamil Hydrochloride Extended-Release Capsules, 300 mg|DRUG: Verelan® PM Extended-Release Capsules, 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Intravenous Methylene Blue for Treating Refractory Neonatal Septic Shock
Status: NOT_YET_RECRUITING
Conditions: Neonatal Sepsis|Shock, Septic
Interventions: DRUG: Methylene Blue|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CHROENDOHNPCC: Early Detection of Pre-cancer Lesions in Adults With Hereditary Nonpolyposis Colorectal Cancer Syndrome
Status: COMPLETED
Conditions: Colorectal Neoplasms, Hereditary Nonpolyposis
Interventions: PROCEDURE: Colonoscopy with chromoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Shade Matching Capacity of a Contemporary Composite Dental Material
Status: SUSPENDED
Conditions: Dental Restoration
Interventions: OTHER: OMNISHADE|OTHER: MULTISHADE|DIAGNOSTIC_TEST: Instrumental Shade Analysis|OTHER: Visual Shade Analysis|OTHER: Patient satisfaction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Efficacy of Relenza Against Influenza A and B
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|Bronchospasm|Influenza, Human|Asthma|Respiratory Disease|Exacerbation of COPD|Bronchitis|Otitis Maedia|Pneumonia|Sinusitis
Interventions: DRUG: Receiving a prescription of Relenza for prophylaxis|OTHER: No prophylaxis with Relenza
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Effect of SYN-004 on the PK of IV Ceftriaxone in Adults With a Functioning Ileostomy
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Period 1 - Treatment Sequence AB|DRUG: Period 1 - Treatment Sequence AC|DRUG: Period 2 - Treatment Sequence AB|DRUG: Period 2 - Treatment Sequence AC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impacts of Cash Transfers on Child Neurodevelopment (Auxilio Brasil)
Status: NOT_YET_RECRUITING
Conditions: Inflammation|HPA|CBCL|Family Relations
Interventions: OTHER: Supplemental cash transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Clinical Study of TQB2618 Injection Monotherapy and Combination Regimen (With Penpulimab Injection ±Anlotinib Hydrochloride Capsules) in the Four or Later Lines of Treatment of Advanced Colorectal Cancer.
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: TQB2618 injection|DRUG: Penpulimab injection|DRUG: Anlotinib hydrochloride capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Satiety in the Effect of Portion Size on Intake
Status: TERMINATED
Conditions: Feeding Behavior
Interventions: OTHER: 100% Portion Size|OTHER: 125% Portion Size|OTHER: 150% Portion Size|OTHER: 175% Portion Size
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sinusoidal Galvanic Vestibular Stimulation for Neurogenic Orthostatic Hypotension / Syncope
Status: WITHDRAWN
Conditions: Neurogenic Orthostatic Hypotension
Interventions: DEVICE: Sinosuidal Galvanic Vestibular Stimulation|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Venous Distension in Patients With Aneurysmatic Arterial Disease
Status: COMPLETED
Conditions: Aortic Aneurysm, Abdominal|Popliteal Artery Aneurysm|Peripheral Arterial Occlusive Disease|Vascular Diseases|Aortic Diseases|Varicose Veins
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preoperative Immunonutrition in Patients Undergoing Elective Colorectal Surgery for Neoplasm
Status: NOT_YET_RECRUITING
Conditions: Cancer of Colon|Nutrition Related Cancer
Interventions: OTHER: Placebo|DIETARY_SUPPLEMENT: Oral Impact Nestle|PROCEDURE: Colorectal surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of a Potential Oral Treatment to Prevent COVID-19 in Adults Who Are Exposed to Household Member(s) With a Confirmed Symptomatic COVID-19 Infection
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: PF-07321332|DRUG: Placebo for PF-07321332|DRUG: Placebo for Ritonavir|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Ultrasonic Osteotome and Conventional Drill Osteotome
Status: COMPLETED
Conditions: Arthrodesis
Interventions: DEVICE: ultrasonic osteotome|DEVICE: drill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Accuracy of CT-FFR Compared to Invasive Coronar Angiography With Fractional Flow Reserve
Status: COMPLETED
Conditions: Coronary Disease
Interventions: DIAGNOSTIC_TEST: CT-FFR|DIAGNOSTIC_TEST: Stress echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC