pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Neuronavigated Repetitive Transcranial Magnetic Stimulation (nrTMS) of the Dorsolateral Prefrontal and Primary Motor Cortex for the Treatment of Chronic Pain
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DEVICE: navigated repetitive Transcranial Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Performance Evaluation of Daily Disposable Contact Lenses in Habitual Lens Wearers Who Use Digital Devices Frequently
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Control Lens (stenfilcon A)|DEVICE: Test Lens (senofilcon A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of RO7490677 In Participants With Myelofibrosis
Status: COMPLETED
Conditions: Primary Myelofibrosis|Polycythemia Vera|Post-Essential Thrombocythemia Myelofibrosis
Interventions: BIOLOGICAL: RO7490677|DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy With or Without Bicalutamide and Goserelin in Treating Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: bicalutamide|DRUG: goserelin acetate|PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of TAK-981 Given With Pembrolizumab in Participants With Select Advanced or Metastatic Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced or Metastatic Solid Tumors
Interventions: DRUG: TAK-981|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: M-2018-334 in Hematological Malignancies
Status: NOT_YET_RECRUITING
Conditions: Hematological Malignancies
Interventions: DEVICE: CliniMACS Prodigy® LP-TCRα/β-19-45RA (Trial Version)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenomics of Methadone in Spine Fusion Surgery
Status: WITHDRAWN
Conditions: Scoliosis|Kyphosis
Interventions: DRUG: Methadone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Total-Body Irradiation Followed By Cyclosporine and Mycophenolate Mofetil in Treating Patients With Severe Combined Immunodeficiency Undergoing Donor Bone Marrow Transplant
Status: COMPLETED
Conditions: Adenosine Deaminase Deficiency|Autosomal Recessive Disorder|Immune System Disorder|Purine-Nucleoside Phosphorylase Deficiency|Severe Combined Immunodeficiency|Severe Combined Immunodeficiency With Absence of T and B Cells|X-Linked Severe Combined Immunodeficiency
Interventions: PROCEDURE: Allogeneic Bone Marrow Transplantation|DRUG: Cyclosporine|OTHER: Laboratory Biomarker Analysis|DRUG: Mycophenolate Mofetil|PROCEDURE: Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation|RADIATION: Total-Body Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of NOVOTTF-200A In Bevacizumab-Naive Subjects With Recurrent Grade III Malignant Astrocytoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Astrocytoma, Grade III
Interventions: DEVICE: NOVOTTF-200A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Feasibility of the Mitralign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS) Also Known as TriAlign™.
Status: UNKNOWN
Conditions: Chronic Symptomatic Functional Tricuspid Regurgitation|Tricuspid Valve Insufficiency|Heart Valve Disease
Interventions: DEVICE: Mitralign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Compound Edaravone Injection for Treatment of Acute Ischemic Stroke
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Compound Edaravone Injection|DRUG: Edaravone Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Correlation of Muscle Ultrasound Measures (2D and 3D) With Biphotonic X-ray Absorptiometry in Oldest Old Patients.
Status: COMPLETED
Conditions: Assessment, Self|Muscle Atrophy|Ultrasound Therapy; Complications|Aging
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cabozantinib to Treat Recurrent Liver Cancer Post Transplant
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Recurrent Cancer|Liver Transplant
Interventions: DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MEK Inhibitor PD-325901 To Treat Advanced Breast Cancer, Colon Cancer, And Melanoma.
Status: TERMINATED
Conditions: Melanoma|Colonic Neoplasms|Breast Neoplasms
Interventions: DRUG: PD-0325901
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Aquatic Exercises for Improving Mental and Physical Health in Adults.
Status: RECRUITING
Conditions: Depression|Depressive Symptoms|Anxiety
Interventions: OTHER: Aquatic Exercises|OTHER: Watsu
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: mHealth for Young Adult Cancer Survivors
Status: RECRUITING
Conditions: Survivorship|Cancer|Psychological Well-Being
Interventions: BEHAVIORAL: an empirically supported protocol, further refined with evidence-based strategies|BEHAVIORAL: Health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus|Coronary Artery Disease
Interventions: DRUG: Ginkgo Biloba Extract (GBE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modulation by Sex Hormones of Inflammation and Susceptibility to Pseudomonas Aeruginosa in Cystic Fibrosis Airways
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Hypertonic saline|DRUG: Hypertonic saline|DRUG: Hypertonic saline|DRUG: Hypertonic saline
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neuromuscular Blockade in Patients With Severe Renal Impairment
Status: COMPLETED
Conditions: Neuromuscular Blockade|Renal Impairment
Interventions: DRUG: Cisatracurium + Neostigmine|DRUG: Rocuronium + Sugammadex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Tolerability of Different Doses and Efficacy of PQ912 in Subjects With MCI and Mild AD
Status: COMPLETED
Conditions: Early Alzheimers Disease|Mild Cognitive Impairment Due to AD
Interventions: DRUG: PQ912|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of a Dual Anti-HIV Gene Transfer Construct to Treat HIV-1 Infection
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: Busulfan|BIOLOGICAL: Cal-1 modified HSPC|BIOLOGICAL: Cal-1 modified CD4+ T lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peroral Supplemental Nutrition in End-stage Renal Disease With and Without HIV Comorbidity
Status: COMPLETED
Conditions: End-Stage Renal Disease
Interventions: DIETARY_SUPPLEMENT: peroral high-caloric supplemental nutrition|DIETARY_SUPPLEMENT: peroral supplemental nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical and Radiographic Evaluation of Photodynamic Therapy for Root Canal Treatment of Primary Molars
Status: ENROLLING_BY_INVITATION
Conditions: Photodynamic Therapy
Interventions: DEVICE: photodynamic therapy|PROCEDURE: pulpectomy with metapex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: This Study Will Evaluate the Immunogenicity, Reactogenicity and Safety of the Routine Infant Vaccines Pediarix®, Hiberix® and Prevenar 13® When Co-administered With GlaxoSmithKline (GSK) Biologicals' Liquid Human Rotavirus Vaccine (HRV) as Compared to GSK's Licensed Lyophilized Vaccine
Status: COMPLETED
Conditions: Rotavirus Infection|Rotavirus Vaccines
Interventions: BIOLOGICAL: Rotarix|BIOLOGICAL: Pediarix|BIOLOGICAL: Hiberix|BIOLOGICAL: Prevenar 13
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Acupressure on Recovery of Bowel Function in Patients Post Cesarean Section
Status: COMPLETED
Conditions: Acupressure|Post-Op Complication|Cesarean Section|Bowel Ileus
Interventions: DEVICE: Acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Imaging Characteristics of [18F]PI-2620 PET in AD and PSP Patients Using High and Low Specific Activity
Status: COMPLETED
Conditions: Alzheimer Disease|Progressive Supranuclear Palsy
Interventions: DRUG: [18F]-PI2620
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of the Angiotensin II Receptor Antagonist Irbesartan on Biochemical and Functional Markers of Endothelial Dysfunction in Patients With Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: IRBESARTAN|DRUG: Atenolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Pioglitazone for Prevention of Cardiac Allograft Vasculopathy After Heart Transplantation
Status: COMPLETED
Conditions: Cardiac Allograft Vasculopathy
Interventions: DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Aerobic Training in Patients With Ankylosing Spondylitis
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: OTHER: aerobic training|OTHER: Stretching exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Trial of Maintenance Cemiplimab for Head and Neck Squamous Cell Carcinoma (HNSCC)
Status: WITHDRAWN
Conditions: Head and Neck Squamous Cell Carcinoma|HNSCC|Squamous Cell Carcinoma of the Larynx|Squamous Cell Carcinoma of the Oral Cavity|Squamous Cell Carcinoma of Hypopharynx
Interventions: DRUG: Cemiplimab-Rwlc
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lumbopelvic Movement Control: Effect of Injury History, and the Role of Cortical Control and Its Practical Application 2
Status: COMPLETED
Conditions: Biomechanical Phenomena
Interventions: OTHER: motor imagery with action observation|OTHER: physical training|OTHER: combine physical training and motor imagery with action observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of SHR-1905 in Subjects With Severe Uncontrolled Asthma
Status: RECRUITING
Conditions: Asthma
Interventions: DRUG: SHR-1905|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Safety, Drug Levels and Drug Effects of BMS-986196 and Food and Formulation Effects on Relative Absorption Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: BMS-986196|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing Atopic Dermatitis and ALLergies in Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Atopic Dermatitis|Food Allergy in Children|Asthma|Rhinitis, Allergic|Non-communicable Diseases|Obesity|Cardiovascular Disease
Interventions: OTHER: Food intervention|OTHER: Skin care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: MicroRNA Mediates Volatile Anesthetics Preconditioning Induced Artery Protection
Status: UNKNOWN
Conditions: Coronary Artery Bypass Graft Triple Vessel
Interventions: DRUG: volatile anesthetics(isoflurane)|DRUG: propofol intravenous anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Computer Aided Diagnostic Tool on Computed Tomography Images for Diagnosis of Retroperitoneal Tumor in Children
Status: UNKNOWN
Conditions: Wilms' Tumor|Neuroblastoma|Teratoma|Lymphoma|Sarcoma|Germ Cell Tumor
Interventions: DIAGNOSTIC_TEST: Radiomic Algorithm
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Drug-Drug Interaction Study to Estimate the Effect of PF-07321332/Ritonavir and Ritonavir on Midazolam in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Midazolam|DRUG: PF-07321332/ritonavir + Midazolam|DRUG: Ritonavir + Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multicolour Versus Monocolour Specimens Inking After Pancreaticoduodenectomy for Periampullary Cancer
Status: COMPLETED
Conditions: Stage, Pancreatic Cancer|Neoplasm, Residual|Pancreatic Neoplasm|Periampullary Cancer
Interventions: PROCEDURE: Multicolour inking specimens|PROCEDURE: Monocolour inking specimens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Prospective, Multi Centre, Interventional, Non-comparator, Open Label Study to Demonstrate the Efficacy, Safety, and Performance of ConvaFoam™ Dressings in the Management of Indicated Chronic Wound Types.
Status: COMPLETED
Conditions: Chronic Ulcer of Leg or Foot|Pressure Injury
Interventions: DEVICE: ConvaFoam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Location of Nerve Block to Minimize Perioperative Opioid Administration in ACL Surgery: Comparing True Adductor Canal to Proximal Block
Status: COMPLETED
Conditions: ACL Surgery
Interventions: DRUG: ACB within true AC with bupivacaine 0.5% 20cc|DRUG: ACB proximal to true AC with bupivacaine 0.5% 20cc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bronchiectasis and Long Term Azithromycin Treatment
Status: COMPLETED
Conditions: Bronchiectasis|Inflammation
Interventions: DRUG: Azithromycin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Range of Dermo-cosmetic Products to Treat Skin and Nail Toxicity Linked to Bispecific Anti-GPRC5D Bispecific Antibodies in Multiple Myeloma Patients". Myeloma". Descriptive Pilot Study
Status: NOT_YET_RECRUITING
Conditions: Myeloma Multiple
Interventions: OTHER: dermo-cosmetic product
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Methotrexate as a Steroid-sparing Agent in Idiopathic Retroperitoneal Fibrosis: a Randomised, Multicenter Trial
Status: UNKNOWN
Conditions: Idiopathic Retroperitoneal Fibrosis|Perianeurysmal Retroperitoneal Fibrosis|Chronic Periaortitis
Interventions: DRUG: Methotrexate+Prednisone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib and Rituximab for Patients With Waldenstrom's Macroglobulinemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Waldenstrom's Macroglobulinemia
Interventions: DRUG: Bortezomib|DRUG: Rituximab|DRUG: Valacyclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Study of BIIB095 and BIIB074 in Healthy Participants and Participants With Painful Diabetic Polyneuropathy
Status: WITHDRAWN
Conditions: Healthy Volunteers|Diabetic Neuropathies
Interventions: DRUG: BIIB095|DRUG: BIIB074|DRUG: Placebo|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DPX-Survivac and Checkpoint Inhibitor in DLBCL
Status: COMPLETED
Conditions: Adult Diffuse Large Cell Lymphoma|Recurrent|Adult Refractory Diffuse Large B-Cell Lymphoma
Interventions: BIOLOGICAL: DPX-Survivac|BIOLOGICAL: Pembrolizumab|DRUG: Cyclophosphamide 50mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enfortumab Vedotin With Radiation for Locally Advanced Bladder Cancer (CONSOLIDATE)
Status: NOT_YET_RECRUITING
Conditions: Advanced Bladder Cancer
Interventions: DRUG: Enfortumab Vedotin|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Gene Variants on Dopamine Receptor Natriuretic Responses
Status: UNKNOWN
Conditions: Hypertension
Interventions: DRUG: fenoldopam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin C, Thiamine, and Steroids in Sepsis
Status: COMPLETED
Conditions: Sepsis
Interventions: DRUG: Vitamin C|DRUG: Thiamine|DRUG: Hydrocortisone|DRUG: Vitamin C Placebo|DRUG: Thiamine Placebo|DRUG: Hydrocortisone Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Promoting Engagement and COVID-19 Testing for Health
Status: RECRUITING
Conditions: COVID-19
Interventions: BEHAVIORAL: COVID-19 Test Reporting|BEHAVIORAL: Personalized Nudges via Text Messaging|BEHAVIORAL: Non-personalized Nudges via Text Messaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Beta-Cell Function After Near-Normalisation of Blood Glucose
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: glucagon-like peptide-1,|DRUG: glucose dependent insulinotropic polypeptide|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Nerve Block Therapy for Bulbar Palsy Pharyngeal Dysphagia
Status: COMPLETED
Conditions: Bulbar Palsy
Interventions: PROCEDURE: Nerve Block|DRUG: Lidocaine Hydrochloride|BEHAVIORAL: routine therapy|PROCEDURE: placebo block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of CHS-0214 to Enbrel (Etanercept) in Patients With Rheumatoid Arthritis (RA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Etanercept|DRUG: CHS-0214
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cryoablation Combined With Cardonilizumab and Bevacizumab in Hepatocellular Carcinoma With Pulmonary Metastases
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Liver Cancer Stage IV|Pulmonary Metastases|Cadonilimab|Bevacizumab|Cryoablation
Interventions: DRUG: Cadonilimab|DRUG: Bevacizumab|PROCEDURE: Cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Preauricular Retromandibular Anteroparotid Versus Retromandibular Through Parotid Approach
Status: COMPLETED
Conditions: Subcondylar Process of Mandible Open Fracture|Facial Nerve Injuries
Interventions: PROCEDURE: PRA approach|PROCEDURE: RT approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dose-Finding Study of Vadadustat in Japanese Subjects With Anemia Secondary to Dialysis-Dependent Chronic Kidney Disease (DD-CKD)
Status: COMPLETED
Conditions: Anemia|Dialysis Dependent Chronic Kidney Disease
Interventions: DRUG: Vadadustat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validating Cardiac MRI Biomarkers and Genotype-Phenotype Correlations for DMD
Status: COMPLETED
Conditions: Muscular Dystrophy, Duchenne
Interventions: OTHER: Cardiac MRI with contrast|OTHER: Cardiac MRI without contrast|OTHER: Blood Test|OTHER: Heart Rate|OTHER: Pulmonary Function Test|OTHER: Genetic Testing|OTHER: Repeat MRI scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pilot Study: Changing Multiple Behaviors in Post-Angioplasty Patients
Status: COMPLETED
Conditions: Angioplasty Patients
Interventions: BEHAVIORAL: Positive affect induction and /or self affirmation induction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose:
Clinical trial: Impact of Vitamin D Supplementation on Cardiometabolic Status and Androgen Profile in Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Evaluations, Diagnostic Self|Treatment Adherence
Interventions: DIETARY_SUPPLEMENT: cholecalciferol (vit D3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: ASpirin as a Treatment for ARDS (STAR): a Phase 2 Randomised Control Trial
Status: TERMINATED
Conditions: Acute Respiratory Distress Syndrome
Interventions: DRUG: Aspirin 75mg|DRUG: Lactose powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dovitinib (TKI258) in the Treatment of Patients With Relapsed Glioblastoma
Status: UNKNOWN
Conditions: First or Second Recurrence of Glioblastoma
Interventions: DRUG: Dovitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lysteda Pediatric Research Equity Act (PREA) Pharmacokinetic Study in Adolescent Females With Heavy Menstrual Bleeding
Status: COMPLETED
Conditions: Menorrhagia
Interventions: DRUG: tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Cholera Anti-Secretory Treatment Trial
Status: COMPLETED
Conditions: Cholera
Interventions: DRUG: iOWH032|DRUG: Placebo|OTHER: V. cholerae Challenge|DRUG: Antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immobilization and Neurological Complications in Patients With Vertebral Osteomyelitis.
Status: COMPLETED
Conditions: Vertebral Osteomyelitis|Spondylodiscitis
Interventions: OTHER: protocols and practices for the immobilization of vertebral osteomyelitis in different French hospitals and bone and joint infections Centers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Covid-19 Effects on Arterial Stiffness and Vascular Aging (CARTESIAN)
Status: RECRUITING
Conditions: Covid19|Arterial Stiffness|Endothelial Dysfunction|Diastolic Dysfunction
Interventions: DIAGNOSTIC_TEST: carotid-femoral pulse-wave velocity
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Ranolazine for the Treatment of Amyotrophic Lateral Sclerosis
Status: RECRUITING
Conditions: ALS
Interventions: DRUG: Ranolazine 500 MG|DRUG: Ranolazine 1000 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VALO-2: Study Evaluating the Safety and Efficacy of PTX022 in the Treatment of Adults With Pachyonychia Congenita
Status: COMPLETED
Conditions: Pachyonychia Congenita
Interventions: DRUG: PTX-022
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Safety and Pharmacokinetic Characteristics of LBEC0101 25 mg With Those of Enbrel®
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LBEC0101|DRUG: Enbrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Study of EDP1503 in Patients With Colorectal Cancer, Breast Cancer, and Checkpoint Inhibitor Relapsed Tumors
Status: COMPLETED
Conditions: Colorectal Cancer Metastatic|Triple Negative Breast Cancer|Non Small Cell Lung Cancer|Bladder Cancer|GastroEsophageal Cancer|Renal Cell Carcinoma|MSI-H
Interventions: BIOLOGICAL: EDP1503|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enzalutamide in Combination With PSA-TRICOM in Patients With Non-Metastatic Castration Sensitive Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: PROSTVAC-F (Fowlpox)/TRICOM|BIOLOGICAL: PROSTVAC-V (Vaccinia)/TRICOM|DRUG: Enzalutamide (Xtandi)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating QTc, PK, Safety of Gemtuzumab Ozogamicin (GO) in Patients With CD33+ R/R AML
Status: COMPLETED
Conditions: ECG|Pharmacokinetics|Safety
Interventions: DRUG: Gemtuzumab Ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Tolerability and Pharmacokinetics of Oral NIM-1324 in Healthy Adult Male and Female Volunteers
Status: COMPLETED
Conditions: Normal Healthy Volunteers
Interventions: DRUG: NIM-1324|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single and Repeat Dose PK/PD Study to Characterise Biomarker Response in Healthy Subjects Treated With Azithromycin
Status: COMPLETED
Conditions: Autoimmune Diseases
Interventions: DRUG: Azithromycin - 250 mg|DRUG: Azithromycin - 1000 mg|DRUG: Azithromycin - 250 mg every other day for 3 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pharmacokinetic Trial of Naproxen Sodium and Diphenhydramine Hydrochloride Soft Capsules Versus Naproxen Sodium and Diphenhydramine Hydrochloride Tablets in Healthy Adult Subjects
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Naproxen sodium and diphenhydramine hydrochloride soft capsules|DRUG: Naproxen sodium and diphenhydramine hydrochloride coated tablets (Aleve, PMBAY98-7111)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analysis of Biopsy Specimens to Study Responses to PD-1 or PD-L1 Therapies
Status: WITHDRAWN
Conditions: Non Small Cell Lung Cancer
Interventions: DIAGNOSTIC_TEST: Pre-Treatment Biopsy|DIAGNOSTIC_TEST: On-Treatment Biopsy|DIAGNOSTIC_TEST: Biopsy at Disease Progression|DIAGNOSTIC_TEST: Peripheral Blood-Based Studies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: First in Human Study of M4344 in Participants With Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor|Advanced Solid Tumor
Interventions: DRUG: M4344 10 mg BIW|DRUG: M4344 20 mg BIW|DRUG: M4344 40 mg BIW|DRUG: M4344 80 mg BIW|DRUG: M4344 160 mg BIW|DRUG: M4344 300 mg BIW|DRUG: M4344 450 mg BIW|DRUG: M4344 700 mg BIW|DRUG: M4344 1050 mg BIW|DRUG: M4344 1200 mg BIW|DRUG: M4344 100 mg BID|DRUG: M4344 150 mg QD|DRUG: M4344 250 mg QD|DRUG: M4344 350 mg QD|DRUG: M4344 400 mg|DRUG: M4344 500 mg|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DENEX Renal Denervation in Patients With Hypertension on no Antihypertensive Medications
Status: RECRUITING
Conditions: Hypertension|Vascular Diseases|Cardiovascular Diseases
Interventions: DEVICE: Renal denervation|PROCEDURE: Renal angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Acetyl-L-Carnitine in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Type 2|Hypertension
Interventions: DRUG: acetyl-L-carnitine/statin (simvastatin)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BFR Training on Muscle Morphology
Status: NOT_YET_RECRUITING
Conditions: Blood Flow Restriction Training|Eccentric Training|Muscle Morphology|Patellofemoral Pain Syndrome|Anterior Cruciate Ligament Injuries
Interventions: PROCEDURE: Low load-BFRt|PROCEDURE: Sham Low load-BFRt|PROCEDURE: High load-Eccentric training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of Serum Free Avonex and Serum Containing Avonex in Healthy Volunteers
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Serum containing Avonex|DRUG: Serum Free Avonex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial of Antigen Pulsed Dendritic Cells (APDC) in Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: BIOLOGICAL: APDC + Chemotherapy|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of a Newborn Screening for Spinal Muscular Atrophy (SMA) in France: DEPISMA Prefigurator Project in Grand-Est and Nouvelle-Aquitaine
Status: RECRUITING
Conditions: Feasibility of Neonatal Screening for Spinal Amyotrophy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics, Food Effect, and Drug-Drug Interaction Potential of ACHN-383 and ACHN-789
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: ACHN-383|DRUG: ACHN-789|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intraosseous Access in the Emergency Department for Patients With Failed Attempts at Intravenous Access: A Randomized Trial Examining Resource Utilization and Patient Satisfaction
Status: COMPLETED
Conditions: Difficult Peripheral IV Access
Interventions: PROCEDURE: IO access using EZ-IO®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Intravenous, Rectal, Intravesical, Vaginal, and Transdermal Melatonin in Healthy Female Volunteers
Status: COMPLETED
Conditions: Melatonin|Pharmacokinetics|Safety
Interventions: DRUG: Melatonin 25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Electrical Phrenic Nerve Stimulation in Patients With VIDD
Status: RECRUITING
Conditions: Diaphragms|Phrenic Nerves
Interventions: DEVICE: transcutaneous electrical phrenic nerve stimulation (TEPNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Probiotic and Zinc Supplementation on the Common Cold
Status: UNKNOWN
Conditions: Common Cold
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Avoiding Diabetes After Pregnancy Trial
Status: COMPLETED
Conditions: Weight Reduction
Interventions: BEHAVIORAL: Weight Reduction Intervention|BEHAVIORAL: Weight Reduction Control Arm|BEHAVIORAL: Tested for diabetes|BEHAVIORAL: Not tested for diabetes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Clinical and Hospital Stay Effects of Reiki and Manual Therapy After Open Heart Surgery
Status: COMPLETED
Conditions: Coronary Artery Diseases|Valvular Heart Diseases
Interventions: OTHER: Reiki/manual therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemoembolization and Radiofrequency Ablation for Hepatocellular Carcinoma Greater Than 3 cm
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: chemoembolization ,Radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Neo-Bio-ADAURA: A Phase II Study to Evaluate Mechanisms of Resistance to Neoadjuvant Osimertinib
Status: NOT_YET_RECRUITING
Conditions: Non-squamous NSCLC
Interventions: DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibedrift- A Trial Comparing a New Approach to Musculoskeletal Pain Consisting of Education and Peer Involvement to Treatment as Usual
Status: COMPLETED
Conditions: Neck Pain Musculoskeletal|Back Pain Lower Back
Interventions: BEHAVIORAL: Information and Peer advisor|BEHAVIORAL: Information, peer advisor and fast referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase Ib Study of SAR650984 in Combination With Carfilzomib for Treatment of Relapsed or Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: Isatuximab|DRUG: Carfilzomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transthoracic Echocardiography of Inferior Vena Cava Before Spinal Anesthesia Can Predict Hypotension
Status: COMPLETED
Conditions: Spinal Anesthetic Toxicity|Inferior Vena Cava Abnormality|Intraoperative Complications
Interventions: PROCEDURE: spinal anesthesia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of CC-98633, BCMA-targeted Chimeric Antigen Receptor (CAR) T Cells, in Participants With Relapsed and/or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: CC-98633
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of Safety and Immune Activity of New Immunotherapeutic Agents for HDM Allergic Rhinitis Patients
Status: ENROLLING_BY_INVITATION
Conditions: Mite Allergy|Rhinitis, Allergic|House Dust Mite Rhinitis
Interventions: DRUG: House Dust Mite Extract, Dermatophagoides Farinae
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgical Scar Treatment With the Pulsed Dye Laser in Combination With a CO2 Laser
Status: COMPLETED
Conditions: Scars
Interventions: DEVICE: Pulsed dye laser treatment|DEVICE: CO2 laser treatment|DEVICE: Combined PDL and CO2 laser treatment|DEVICE: Split PDL and CO2 Laser treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgery Alone or With CYC VBL and PRED or CVP Alone in Stage IA or IIA Nodular Lymphocyte-Predominant Hodgkin Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: cyclophosphamide|DRUG: prednisolone|DRUG: vinblastine sulfate|OTHER: watchful waiting|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Low Dose Combination of Linagliptin + Metformin to Prevent Diabetes
Status: UNKNOWN
Conditions: Prediabetic State|Insulin Resistance
Interventions: COMBINATION_PRODUCT: Linagliptin + metformin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Azadirachta Indica in Treating Patients With Chronic Lymphocytic Leukemia
Status: WITHDRAWN
Conditions: Refractory Chronic Lymphocytic Leukemia|Stage II Chronic Lymphocytic Leukemia|Stage III Chronic Lymphocytic Leukemia|Stage IV Chronic Lymphocytic Leukemia
Interventions: OTHER: laboratory biomarker analysis|GENETIC: western blotting|GENETIC: gene expression analysis|OTHER: pharmacological study|OTHER: flow cytometry|GENETIC: fluorescence in situ hybridization|BIOLOGICAL: azadirachta indica|GENETIC: reverse transcriptase-polymerase chain reaction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Virtual Reality Game on Upper Limb Movement in Individuals With Stroke
Status: UNKNOWN
Conditions: Stroke|Movement, Abnormal
Interventions: OTHER: Virtual reality with feedback|OTHER: Virtual reality without feedback|OTHER: Healthy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Insulin Tolerance Test Study in Patients With Type 1 Diabetes
Status: TERMINATED
Conditions: Type 1 Diabetes|Hypoglycemia
Interventions: DRUG: Pitolisant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bioequivalence Study of Olanzapine Orally Disintegrating Tablets, 5 mg Under Fed Condition
Status: COMPLETED
Conditions: Fed
Interventions: DRUG: Olanzapine OD Tablets 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral Hygienization in Newborn on Candida Spp Colonization
Status: UNKNOWN
Conditions: Newborns|Oral Hygiene|Candidiasis, Oral|Behavior
Interventions: BEHAVIORAL: oral hygiene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Moderate Alcohol Consumption to Cognitive Functioning After Roux-en Y Gastric Bypass
Status: COMPLETED
Conditions: Bariatric Surgery|Alcohol Consumption|Cognitive Function
Interventions: BEHAVIORAL: 250 ml alcohol consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Performance of Two Intraocular Lenses With Extended Depth of Vision
Status: UNKNOWN
Conditions: Cataract Senile
Interventions: DEVICE: non-diffractive monofocal IOL|DEVICE: standard EDOF IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Creatine in Treating Patients With Cancer-Associated Weight Loss
Status: COMPLETED
Conditions: Anorexia|Cachexia|Unspecified Adult Solid Tumor, Protocol Specific|Weight Changes
Interventions: DIETARY_SUPPLEMENT: creatine monohydrate|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Trial of Biolimus-coated Intracranial Balloon Dilation Catheter
Status: NOT_YET_RECRUITING
Conditions: Intracranial Atherosclerotic Stenosis
Interventions: DEVICE: Drug balloon dilated|DEVICE: balloon dilated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of BioBlock® Intranasally Administered Virus-Neutralizing Bovine Colostrum Nasal Spray in Preventing of COVID-19 (Coronavirus Disease-19) Infection in Healthy Volunteer Individuals
Status: UNKNOWN
Conditions: SARS CoV 2 Infection
Interventions: BIOLOGICAL: BioBlock® antiviral nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Phase II Neoadjuvant Trial of Trastuzumab in Combination With Dose-Dense ABI-007 (Abraxane™)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Pre operativeTrastuzumab|DRUG: ABI-007 (Abraxane)|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sildenafil Impact on Ventricular Function in Patients With Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Sildenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy Administered Under the Tongue to Treat Dust Mite Allergy
Status: COMPLETED
Conditions: Asthma
Interventions: BIOLOGICAL: House Dust Mite SLIT|BIOLOGICAL: High dose SLIT|BIOLOGICAL: Placebo SLIT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Single Trocar Cholecystectomy to Standard Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Cholelithiasis
Interventions: PROCEDURE: Single trocar cholecystectomy|PROCEDURE: Standard laparoscopic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Early Bactericidal Activity of Tedizolid and Linezolide Against Mycobacterium Tuberculosis (TEDITUB)
Status: RECRUITING
Conditions: Tuberculosis|Multidrug Resistant Tuberculosis
Interventions: DRUG: Tedizolid arm (SIVEXTRO®)|DRUG: Linezolid arm (ZYVOXID®)|DRUG: Standard quadruple therapy arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Immunogenicity of Trivalent Influenza Vaccine, Formulation 2015 Southern Hemisphere, When Administered to Healthy Adult Subjects.
Status: COMPLETED
Conditions: Human Influenza
Interventions: BIOLOGICAL: Aggripal®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Whole Body Vibration on Blood Pressure in Obese Postmenopausal Women.
Status: NOT_YET_RECRUITING
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: energy-restricted diet|DEVICE: Whole body vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT