pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: OPTIMIZE PCI: Multicenter Randomized Trial of OCT Compared to IVUS and Angiography to Guide Coronary Stent Implantation
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Coronary PCI guided by IVUS|PROCEDURE: Coronary PCI guided by OCT|PROCEDURE: Coronary PCI guided by Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Impact of Methylphenidate on Neural Response in Disruptive Behavioral Disorder
Status: WITHDRAWN
Conditions: Conduct Disorder|Attention Defict Hyperactivity Disorder
Interventions: DRUG: Methylphenidate Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Mindfulness-Based Intervention to Improve CPAP
Status: RECRUITING
Conditions: Obstructive Sleep Apnea (Moderate to Severe)|Obstructive Sleep Apnea
Interventions: OTHER: Mindfulness Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Single-Arm Phase II Clinical Study of Pemigatinib in the Treatment of Advanced Non-Small Cell Lung Cancer Patients With FGFR Alterations Who Have Failed Standard Therapy
Status: RECRUITING
Conditions: Advanced Non-Small Cell Lung Cancer
Interventions: DRUG: Pemigatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Recovery Between Intubated and Non-intubated Thoracic Surgery
Status: COMPLETED
Conditions: Cognition
Interventions: PROCEDURE: Nonintubated|PROCEDURE: Intubated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reproductive Outcomes After a Previous Episode of Tubal Ectopic Pregnancy in Patients Managed Expectantly and Surgically
Status: COMPLETED
Conditions: Ectopic Pregnancy
Interventions: OTHER: Expectant management|PROCEDURE: Salpingectomy|PROCEDURE: Salpingostomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: REU-stop - Effect of Intensive Smoking Cessation Intervention on Smoking Cessation and Disease Activity in Patients With Rheumatoid Arthritis.
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: BEHAVIORAL: Intensive smoking cessation intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ExAblate Treatment of Uterine Fibroids for Fertility Enhancement
Status: TERMINATED
Conditions: Uterine Fibroids, With Unexplained Infertility
Interventions: DEVICE: ExAblate 2000|PROCEDURE: Myomectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Tolerability of Selonsertib (GS-4997) in Participants With Diabetic Kidney Disease
Status: COMPLETED
Conditions: Diabetic Kidney Disease
Interventions: DRUG: Selonsertib|DRUG: Placebo to match selonsertib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Long-term Extension Study of E2007 in Patients With Refractory Partial Seizures Uncontrolled With Other Anti-Epileptic Drugs (AEDs)
Status: COMPLETED
Conditions: Refractory Partial Seizures
Interventions: DRUG: perampanel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Untargeted Metabolomics to Identify Urinary Biomarkers of Onion Intake
Status: ACTIVE_NOT_RECRUITING
Conditions: Metabolomics
Interventions: OTHER: Onion Feeding|OTHER: Couscous Feeding|OTHER: Onion Supplementation Period
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Abstinence-Linked Money Management Multisite
Status: COMPLETED
Conditions: Dual Diagnosis|Cocaine Abuse|Cocaine Dependence|Polysubstance Abuse
Interventions: BEHAVIORAL: ATM|BEHAVIORAL: Individual Drug Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Local Vibration in Multiple Sclerosis Patients
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: OTHER: Standard physiotherapy program+50 Hz local vibration|OTHER: Standard physiotherapy program+100 Hz local vibration|OTHER: Standard physiotherapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Identification of Olfactory Biomarkers of Skin Cancer From Skin Odor Samples: a Pilot Study
Status: NOT_YET_RECRUITING
Conditions: Identify Volatile Biomarkers Specific to Malignant Melanoma, Basal Cell Carcinoma and Squamous Cell Carcinoma|Verify That the Volatile Biomarkers Identified Derive From Metabolic Changes in Body Odour and Not Just From Changes in the Surface of Cancerous Lesions
Interventions: OTHER: Collection of body odor samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Subepithelial Connective Tissue Graft Versus Acellular Dermal Matrix With Tunnel Technique in Treatment of Multiple Gingival Recessions
Status: UNKNOWN
Conditions: Gingival Recession
Interventions: BIOLOGICAL: Acellular Dermal Matrix|PROCEDURE: Tunnel technique with the subepithelial connective tissue graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone at Lower Concentration Ropivacaine in the Supraclavicular Nerve Block
Status: UNKNOWN
Conditions: Analgesia|Motor Activity|Brachial Plexus Block
Interventions: DRUG: Ropivacaine 0.5% 20mL|DRUG: Ropivacaine 0.25% 20ml|DRUG: Ropivacaine 0.25% 20ml + dexamethasone 8mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Iron Isomaltoside/Ferric Derisomaltose vs Iron Sucrose for the Treatment of Iron Deficiency Anemia (IDA)
Status: COMPLETED
Conditions: Iron Deficiency Anaemia|Iron Deficiency Anemia
Interventions: DRUG: Iron isomaltoside/ferric derisomaltose|DRUG: Iron sucrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Chemically Activated Composite Resin Alkasite in Atypical Caries Lesions of Deciduous Teeth
Status: UNKNOWN
Conditions: Dental Caries in Children
Interventions: PROCEDURE: Dental Restoration with Chemically activated Composite resin Alkasite|PROCEDURE: Dental Restoration with Resin-Modified Glass ionomer Cement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Repeated iTBS Cycloserine Motor Plasticity
Status: COMPLETED
Conditions: Motor Activity
Interventions: DEVICE: Transcranial Magnetic Stimulation|DRUG: Cycloserine|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prospective Evaluation of Vitagel for Reduction in Blood Loss and Pain Following Unilateral Total Knee Arthroplasty
Status: COMPLETED
Conditions: Arthritis
Interventions: DEVICE: Vitagel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OTO-201 for Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement
Status: COMPLETED
Conditions: Bilateral Middle Ear Effusion Requiring Tympanostomy Tube Placement
Interventions: DRUG: OTO-201|DRUG: Placebo|DRUG: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Induction Chemotherapy for Locally Recurrent Rectal Cancer
Status: RECRUITING
Conditions: Recurrent Rectal Cancer
Interventions: DRUG: Combination drug|RADIATION: Chemoradiotherapy|PROCEDURE: Surgery locally recurrent rectal cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (IMbrave152)
Status: RECRUITING
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Atezolizumab|DRUG: Bevacizumab|DRUG: Tiragolumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Testing Salicylic Acid Peels Versus Glycolic Acid Peels for the Treatment of Melasma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanosis
Interventions: OTHER: Salicylic Acid Peels|OTHER: Glycolic Acid Peels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Probiotic Supplementation on SARS-CoV-2 Antibody Response After COVID-19
Status: COMPLETED
Conditions: Covid19
Interventions: DIETARY_SUPPLEMENT: L. reuteri DSM 17938 + vitamin D|DIETARY_SUPPLEMENT: Placebo + vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Pembrolizumab Plus Chemotherapy With Lenvatinib for Malignant Pleural Mesothelioma
Status: NOT_YET_RECRUITING
Conditions: Malignant Pleural Mesothelioma
Interventions: DRUG: Lenvatinib|DRUG: Pemetrexed|DRUG: Cisplatin/Carboplatin|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hepatic and Cardiac Metabolic Flexibility in Subjects With T2DM With and Without NAFLD
Status: COMPLETED
Conditions: NAFLD - Non-Alcoholic Fatty Liver Disease|Type 2 Diabetes
Interventions: OTHER: Hyperinsulinemic euglycaemic clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Glucose-dependent Insulinotropic Polypeptide on the Alpha Cell Response to Hypoglycaemia in Patients With Type 1 Diabetes
Status: RECRUITING
Conditions: Type1diabetes|Hypoglycemia|Type 1 Diabetes
Interventions: OTHER: Infusion of GIP[1-42], GIP[1-30] or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Regional Anesthesia Versus General Anesthesia
Status: COMPLETED
Conditions: Postoperative Pain|Anesthesia
Interventions: DRUG: Midazolam|DRUG: Sufentanil|DRUG: Propofol|DRUG: Rocuronium|DRUG: Sevoflurane|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Targeting Personalized Brain States Reflecting Strong and Weak Corticospinal Tract Output in Real-time
Status: ACTIVE_NOT_RECRUITING
Conditions: Neurotypical Adults
Interventions: DEVICE: Personalized brain state-dependent single-pulse TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Futibatinib and Pembrolizumab for Treatment of Advanced or Metastatic FGF19 Positive BCLC Stage A, B, or C Liver Cancer
Status: RECRUITING
Conditions: Advanced Hepatocellular Carcinoma|BCLC Stage A Hepatocellular Carcinoma|BCLC Stage B Hepatocellular Carcinoma|BCLC Stage C Hepatocellular Carcinoma|Metastatic Hepatocellular Carcinoma
Interventions: DRUG: Futibatinib|BIOLOGICAL: Pembrolizumab|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Inhaled Insulin Compared to Metformin and Glimepiride in Type 2 Diabetes
Status: TERMINATED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: inhaled human insulin|DRUG: metformin|DRUG: glimepiride|DRUG: inhaled human insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Structured 3D Exercise and the Conventional Exercise Program for Scoliosis in Children With Rheumatic Disease
Status: COMPLETED
Conditions: Scoliosis|Juvenile Idiopathic Arthritis
Interventions: OTHER: Schroth 3-Dimensional scoliosis exercise|OTHER: conventional scoliosis exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of ZotaRolimus-Eluting Coronary Stent System In Patients With Long Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease|Myocardial Ischemia|Coronary Disease
Interventions: DEVICE: Zotarolimus-Eluting Stent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open-Label Safety Study of Acoramidis (AG10) in Symptomatic ATTR Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Amyloid Cardiomyopathy, Transthyretin-Related
Interventions: DRUG: Acoramidis (AG10)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of The Stability of Orthodontic Treatment After First Premolar Extraction Using Combined Retention Protocol
Status: RECRUITING
Conditions: Orthodontic Appliance Complication
Interventions: PROCEDURE: combined protocol of retention (bonded lingual retainer and vacuum formed retainers)|PROCEDURE: Bonded lingual retainer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence of Nomegestrol Acetate (NOMAC) and Estradiol (E2) in Commercial Versus Phase 3 Pivotal Clinical Batches of NOMAC-E2 Tablets (P06328)
Status: COMPLETED
Conditions: Healthy Postmenopausal Females
Interventions: DRUG: Commercial NOMAC-E2|DRUG: Phase 3 NOMAC-E2 "Batch A"|DRUG: Phase 3 NOMAC-E2 "Batch B"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of N1539 Following Abdominoplasty Surgery
Status: COMPLETED
Conditions: Pain, Post-operative
Interventions: DRUG: N1539|DRUG: Intravenous Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Valsartan Administered Once Daily Versus Twice Daily, in Patients With Stable, Chronic Heart Failure
Status: COMPLETED
Conditions: Chronic Heart Failure
Interventions: DRUG: valsartan 160 mg|DRUG: valsartan 160 mg BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: REIMAGINE - Real World EvaluatIon of Mepolizumab in Severe Asthma achievinG on Treatment clinIcal remissioN, a prospEctive Study
Status: NOT_YET_RECRUITING
Conditions: Asthma
Interventions: DRUG: Mepolizumab|OTHER: Spirometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Lenalidomide and Dexamethasone With/Without Stem Cell Transplant in Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: PROCEDURE: Autologous peripheral blood stem cell transplant|DRUG: Lenalidomide|DRUG: Dexamethasone|PROCEDURE: Stem cell collection|DRUG: Melphalan|DRUG: G-CSF|DRUG: Cyclophosphamide|DRUG: Mesna
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Retention of an Orally Administered Device Using Gamma Scintigraphy Study 2
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DEVICE: Polymer based lubricating liquid|DEVICE: Moi-Stir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Probiotic on Protection Against Upper Respiratory Tract Infections in Children
Status: TERMINATED
Conditions: Upper Respiratory Tract Infection
Interventions: DIETARY_SUPPLEMENT: probiotic|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)
Status: RECRUITING
Conditions: Prostatic Neoplasms, Castration-Resistant
Interventions: DRUG: Opevesostat|DRUG: Olaparib|DRUG: Docetaxel|DRUG: Cabazitaxel|DRUG: Fludrocortisone acetate|DRUG: Dexamethasone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Impact of SpO2 Averaging Time on Performance of an Automatic FiO2 Control System: a Randomized Study
Status: UNKNOWN
Conditions: Neonatal Respiratory Distress|Very Low Birth Weight Infant
Interventions: DEVICE: Fabian ventilator with PRICO system (Acutronic Medical Systems AG, Hirzel, Switzerland); SpO2 averaging time set to 4to6 s|DEVICE: Fabian ventilator with PRICO system (Acutronic Medical Systems AG, Hirzel, Switzerland); SpO2 averaging time set to 10 s|DEVICE: Fabian ventilator with PRICO system (Acutronic Medical Systems AG, Hirzel, Switzerland); SpO2 averaging time set to 16 s
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of Exenatide Once Weekly Versus Liraglutide in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: exenatide once weekly|DRUG: liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single and Combined Effects of Behavioral, Academic, and Medication Treatments for ADHD in the Classroom
Status: RECRUITING
Conditions: ADHD
Interventions: DRUG: Methylphenidate Hydrochloride ER|BEHAVIORAL: Behavioral classroom|DRUG: Placebo|BEHAVIORAL: General Classroom|BEHAVIORAL: Academic Accommodations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Backward Gait on Sand on Improving the Gait Parameters of Patients With Chronic Stroke.
Status: UNKNOWN
Conditions: Chronic Stroke
Interventions: OTHER: Backward walking on sand
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Traditional Chinese Medicine on Outcomes in Patients With Mild/Moderate Chronic Obstructive Pulmonary Disease
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Traditional Chinese Medicine|DRUG: placebo chinese medicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Kinesiotaping and Inactivation of Trigger Points in Chronic Myofascial Pain of TMD
Status: COMPLETED
Conditions: Myofascial Pain|TMD
Interventions: DIAGNOSTIC_TEST: Kinesiotaping|DIAGNOSTIC_TEST: inactivation of trigger points (TrP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Implantable Tibial Neuromodulation Pivotal Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Overactive Bladder
Interventions: DEVICE: Medtronic Implantable Tibial Neuromodulation (TNM) System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aerobic Fitness in Overweight and Obese Individuals
Status: TERMINATED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Oxyjun|DIETARY_SUPPLEMENT: Pacebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Phase 2, Multi-Center Trial of Modafinil for Methamphetamine Dependence
Status: COMPLETED
Conditions: Methamphetamine Dependence
Interventions: DRUG: Modafinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ablation Index in Standard vs. High Power Radiofrequency Ablation for Typical Atrial Flutter: A Randomized Study (AITAF)
Status: NOT_YET_RECRUITING
Conditions: Atrial Flutter|Atrial Flutter Typical|Cavotricuspid Isthmus Dependent Macroreentry Tachycardia
Interventions: PROCEDURE: Ablation of the Cavo-tricuspid isthmus for typical Atrial Flutter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Sunscreen in Preventing Skin Rash in Patients Receiving Drugs Such as Erlotinib or Cetuximab for Cancer
Status: COMPLETED
Conditions: Dermatologic Complications|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: sunscreen|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment Using 448 kHz CRMRF in Subacromial Syndrome.
Status: COMPLETED
Conditions: Shoulder Impingement Syndrome|Subacromial Impingement Syndrome
Interventions: DEVICE: Thermal 448 kHz Capacitive Resistive Monopolar Radiofrequency|DEVICE: Subthermal 448 kHz Capacitive Resistive Monopolar Radiofrequency|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Endovascular and Bronchoscopic Tumor Marker Insertion for Real-time Stereotactic-guided Radiotherapy in Lung Cancer
Status: RECRUITING
Conditions: Lung Cancer|Lung Metastases|Radiotherapy
Interventions: PROCEDURE: Endovascular fiducial marker insertion|PROCEDURE: Bronchoscopic fiducial marker insertion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Niraparib Monotherapy as Maintain and Recurrent Treatment of Endometrial Serous Carcinoma
Status: RECRUITING
Conditions: Endometrial Carcinoma|Serous Carcinoma
Interventions: DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastrointestinal Microbiota in Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin
Status: COMPLETED
Conditions: Primary Sclerosing Cholangitis|Biliary Atresia
Interventions: DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Time-restricted Eating on Liver Metabolism
Status: ACTIVE_NOT_RECRUITING
Conditions: NAFLD|Obesity|Nutritional and Metabolic Diseases
Interventions: BEHAVIORAL: Time restricted eating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Intervention in Prevention of Sarcopenia, Frailty and Functional Decline in Pre-frail Community Elderly
Status: ACTIVE_NOT_RECRUITING
Conditions: Muscle Strengh|Frailty|Sarcopenia
Interventions: OTHER: Multidisciplinary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sunitinib and Surgery in Treating Patients With Localized or Metastatic Kidney Cancer
Status: COMPLETED
Conditions: Kidney Cancer
Interventions: DRUG: sunitinib malate|PROCEDURE: neoadjuvant therapy|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Safety of AZD7762 Administered Alone and in Combination With Gemcitabine in Patients With Advanced Solid Malignancies
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: AZD7762|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Stairs as an Outcome Measure in Individuals With Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease
Interventions: OTHER: Patients will ascend and descend a flight of 10 steps
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Dose Finding Study of STR-324
Status: UNKNOWN
Conditions: Pain, Acute
Interventions: DRUG: Morphine|DRUG: Morphine HCl|DRUG: STR-324
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1, Dose-Escalation Study of Oral CNF2024(BIIB021) in CLL
Status: TERMINATED
Conditions: B-Cell Chronic Lymphocytic Leukemia
Interventions: DRUG: CNF2024 (BIIB021)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Multiple Doses of Intranasal Ketorolac in Postoperative Pain Following Major Abdominal Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Intranasal Ketorolac Tromethamine|DRUG: Intranasal Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Randomized, Double-Blind, Placebo-Controlled Study of Oral Iloprost for Raynaud's Phenomenon Secondary to Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis|Raynaud Disease
Interventions: DRUG: iloprost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Clinical Trial to Evaluate the Pharmacokinetics and Safety of MRTX849 in Patients With Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced or Metastatic Solid Tumor
Interventions: DRUG: MRTX849
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Glucosamine on Joint Structure and Quality of Life (JOG)
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DIETARY_SUPPLEMENT: Glucosamine (a dietary supplement)|OTHER: 16 oz lite lemonade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Combination Therapy to Treat COVID-19 Infection
Status: UNKNOWN
Conditions: COVID|Covid-19|Corona Virus Infection|Coronavirus Infection|Coronavirus-19|SARS-CoV2|SARS-CoV Infection
Interventions: DRUG: Ivermectin|DRUG: Doxycycline Hcl|DIETARY_SUPPLEMENT: Zinc|DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Spinal Prilocaine for Caesarian Sections
Status: COMPLETED
Conditions: Combined Spinal Epidural Anesthesia|Prilocaine|Bupivacaine|Pain
Interventions: PROCEDURE: combined spinal epidural anaesthesia|DRUG: Prilocaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of Once-daily Oral Administrations of TZP-102 for Gastroparesis in Patients With Diabetes Mellitus
Status: COMPLETED
Conditions: Gastroparesis|Diabetes Mellitus
Interventions: DRUG: TZP-102|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of SQ109, High-dose Rifampicin, and Moxifloxacin in Adults With Smear-positive Pulmonary TB in a MAMS Design
Status: COMPLETED
Conditions: Tuberculosis, Pulmonary
Interventions: DRUG: SQ109|DRUG: Rifampicin|DRUG: Moxifloxacin|DRUG: isoniazid|DRUG: pyrazinamide|DRUG: ethambutol|DIETARY_SUPPLEMENT: pyridoxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Candesartan Effectiveness Study in Pro-B Type Natriuretic Peptides (BNP)
Status: COMPLETED
Conditions: Hypertension|Left Ventricular Hypertrophy
Interventions: DRUG: Candesartan|DRUG: Candesartan|DRUG: Felodipine|DRUG: Felodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Mindfulness on Opioid Use and Anxiety During Primary Care Buprenorphine Treatment (R33 Phase)
Status: COMPLETED
Conditions: Opioid-use Disorder|Stress Related Disorder|Anxiety|Depression
Interventions: BEHAVIORAL: Live-Online M-ROCC|BEHAVIORAL: Live-Online Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: On-pump Versus Off-pump Coronary Artery Bypass Grafting , Short Term Outcomes , Sohag Experience
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: coronary artery bypass graft CABG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study AnalyZing a NovEl Wearable SeNsor for Remote PatIent Health Monitoring
Status: COMPLETED
Conditions: Heart Failure|Chronic Kidney Diseases
Interventions: DEVICE: CorBand|OTHER: Activity Monitor|OTHER: Bioimpedance spectrometer|OTHER: ECG|OTHER: respiratory rate sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Study Evaluating Antibiotic Use in Reducing Vancomycin-Resistant Enterococci and ESBL Producing Escherichia Coli and Klebsiella Pneumoniae in Intensive Care
Status: COMPLETED
Conditions: Escherichia Coli Infections|Klebsiella Infections
Interventions: DRUG: vancomycin-resistant enterococci and ESBL
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: FlowTriever Pulmonary Embolectomy Clinical Study
Status: COMPLETED
Conditions: Pulmonary Embolism|Acute Pulmonary Embolism|Submassive Pulmonary Embolism|Massive Pulmonary Embolism
Interventions: DEVICE: FlowTriever System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pyroptosis-related Indicators in the Pathogenesis of Vitiligo:Across-sectional Comparative Study
Status: NOT_YET_RECRUITING
Conditions: Vitiligo
Interventions: DIAGNOSTIC_TEST: evaluate serum levels pyroptosis-related indicators (GASDM-D, IL 1β & IL-18)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ampyra for Optic Neuritis in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Optic Neuritis
Interventions: DRUG: Dalfampridine/Placebo|DRUG: Placebo/Dalfampridine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Post Operative Pain in Thyroid Surgery Patients: Perspective Study Acupuncture Versus Drugs
Status: UNKNOWN
Conditions: Post Operative Pain
Interventions: PROCEDURE: Acetaminophen and acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the EZH2 Inhibitor Tazemetostat in Malignant Mesothelioma
Status: COMPLETED
Conditions: Mesothelioma|BAP1 Loss of Function
Interventions: DRUG: Tazemetostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Steroid Before Thyroidectomy
Status: COMPLETED
Conditions: Thyroid Surgery for Benign Disease
Interventions: DRUG: Dexamethason Helvepharm ®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Nivolumab and Bevacizumab in Patients With Advanced and or Metastatic Hepatocellular Carcinoma
Status: TERMINATED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Nivolumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concurrent Radiotherapy and Weekly Chemotherapy of PF for Postoperative Locoregional Recurrence of Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: fluorouracil|DRUG: Cisplatin|RADIATION: Intensity-modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of a Health Promotion Program for Older People With Post-Covid-19 Sarcopenia
Status: NOT_YET_RECRUITING
Conditions: Post COVID-19 Condition
Interventions: OTHER: Protein powder and Resistance exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dextromethorphan, Amantadine and Glucose Homeostasis in Diabetes Subjects
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Dextromethorphan hydrobromide|DRUG: Amantadine|DRUG: Pacebo 1 (placebo for Amantadine)|DRUG: Placebo 2 (fo Dextromethorphan)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Therapeutic Efficacy of 18F-FDG Combined With 18F-FAPI PET/MR in Neoadjuvant Therapy for Gastric Cancer
Status: RECRUITING
Conditions: Cancer
Interventions: DIAGNOSTIC_TEST: 18F-FAPI#18F-FDG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Anti-HIV Therapy Intensification
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Lopinavir/Ritonavir|DRUG: Lamivudine/Zidovudine|DRUG: Tenofovir disoproxil fumarate|BIOLOGICAL: Pneumococcal Vaccine, Polyvalent (23-valent)|DRUG: Lamivudine|DRUG: Stavudine|DRUG: Zidovudine|DRUG: Didanosine|BIOLOGICAL: Lyme Disease Vaccine Recombinant OspA|BIOLOGICAL: Haemophilus B Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Confirmation Study on Lenalidomide With Dexamethasone In Japanese Patients With Previously Treated Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deep Brain Stimulation for Patients With Tardive Dyskinesia and or Dystonia
Status: TERMINATED
Conditions: Tardive Dyskinesia|Tardive Dystonia
Interventions: DEVICE: GPi DBS with Medtronic electorde and Activa PC pulsegenerator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Additional Titration During Oral Appliance Treatment for Sleep-disordered Breathing.
Status: COMPLETED
Conditions: Obstructive Sleep Apnea Syndrome
Interventions: DEVICE: Mandibular Advancement Device (MAD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Infusion of Lidocaine in Colonoscopy
Status: UNKNOWN
Conditions: Sedation
Interventions: DRUG: placebo|DRUG: lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Targeted Vitamin D Treatment of Schizophrenia-Associated Hyperprolinemia
Status: WITHDRAWN
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Cholecalciferol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label,Phase II Trial of MAB Dose Escalation OF Bicalutamide For Biochemical Failure In Prostate Cancer Patients.
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Escalating dose of Casodex from 50mg daily to 150 mg daily
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on a MenACYW Conjugate Vaccine Administered as a Single Dose in Participants Aged 12 Months and Older in Vietnam
Status: COMPLETED
Conditions: Meningococcal Infection|Healthy Volunteers
Interventions: BIOLOGICAL: Meningococcal Polysaccharide (Serogroups A, C, W, and Y) Tetanus Toxoid Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: S086 Tablets for Chronic Heart Failure With Reduced Ejection Fraction
Status: RECRUITING
Conditions: Chronic Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: To evaluate whether the efficacy of the study drug is noninferior to that of the positive control drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Efficacy and Safety of TQB3702 Tablets Combined With Immunochemotherapy for the Treatment of B-cell Lymphoma
Status: NOT_YET_RECRUITING
Conditions: B-cell Lymphoma
Interventions: DRUG: TQB3702 tablets+Chemotherapy regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in the MRI Signal in Patients With Benign Tumors of the Brain and Meninges Treated With Proton Therapy: Impact of TEL and the Biological Dose Received
Status: COMPLETED
Conditions: Benign Brain Tumors|Proton Therapy
Interventions: DEVICE: MRI 3 tesla
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Community Outreach for Palliative Engagement -- Parkinson Disease
Status: RECRUITING
Conditions: Parkinson Disease Dementia|Parkinson Disease|Parkinson's Disease and Parkinsonism|Lewy Body Parkinsonism|Dementia With Lewy Bodies|Progressive Supranuclear Palsy|Corticobasal Degeneration|Multiple System Atrophy|Vascular Parkinsonism
Interventions: OTHER: Parkinson Disease Standard Care|OTHER: Online Community-Supported Palliative Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sedation Regimen in Patients Undergoing Cardiac Electrophysiology Study and Ablation : a Comparison Between Dexmedetomidine-remifentanil and Midazolam-remifentanil Combinations
Status: COMPLETED
Conditions: Cardiac Arrhythmia
Interventions: DRUG: dexmedetomidine-remifentanil|DRUG: midazolam-remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Sepsis|Septic Shock
Interventions: PROCEDURE: Thoracic duct drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Idarubicin vs. Epirubicin TACE in the Treatment of Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Idarubicin Hydrochloride for Injection|DRUG: Epirubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect and Mechanism of Acupuncture on Functional Dyspepsia
Status: UNKNOWN
Conditions: Dyspepsia
Interventions: DEVICE: Acupuncture|DEVICE: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Follow-up Evaluation of Home Nurse Visitation Program for Socially Disadvantaged Women and Their Children
Status: UNKNOWN
Conditions: Risk Reduction Behavior
Interventions: BEHAVIORAL: Developmental Screening|BEHAVIORAL: Screening plus Transportation|BEHAVIORAL: Screening, Transport, Prenatal Visits|BEHAVIORAL: Screen, Transport, Prenatal/Inf Visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Lumateperone in the Acute Treatment of Patients With Bipolar Mania
Status: RECRUITING
Conditions: Bipolar Disorder, Manic
Interventions: DRUG: Lumateperone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Conatumumab/Panitumumab Combination Metastatic Colorectal Cancer Study
Status: COMPLETED
Conditions: Colon Cancer|Colorectal Cancer|Rectal Cancer|Metastatic Colorectal Cancer|Oncology
Interventions: DRUG: Panitumumab|DRUG: Conatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of MCI-186 for Treatment of Amyotrophic Lateral Sclerosis
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis (ALS)
Interventions: DRUG: MCI-186|DRUG: Placebo|DRUG: MCI-186 in open label phase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Matrix Metalloproteinases on the Primary Teeth Pulpotomy Treatments
Status: COMPLETED
Conditions: Reversible Pulpitis
Interventions: DIAGNOSTIC_TEST: Matris metalloproteinase -2, -8, -9 expressions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Extension Study of Ulviprubart (ABC008) in Subjects With Inclusion Body Myositis
Status: NOT_YET_RECRUITING
Conditions: Inclusion Body Myositis (IBM)
Interventions: DRUG: Ulviprubart (ABC008)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacopuncture Therapy for Cervical Disc Herniation: A Pilot Study
Status: COMPLETED
Conditions: Cervical Disc Herniation
Interventions: PROCEDURE: pharmacopuncture therapy|PROCEDURE: acupuncture therapy|PROCEDURE: physical therapy, medication(prn)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hair Removal: Intense Pulsed Light Versus Diode Laser
Status: NOT_YET_RECRUITING
Conditions: Hair Removal
Interventions: DEVICE: Intense Pulsed Light|DEVICE: Diode Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High- and Low-dose Radiotherapy Combined With PD-1 Inhibitors for MSS CRLM
Status: RECRUITING
Conditions: Colorectal Liver Metastases
Interventions: RADIATION: Radiation: High- and Low-dose radiotherapy|DRUG: PD-1 Inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride
Status: COMPLETED
Conditions: Dental Caries in Children|Dental Caries Class II|Dental Caries
Interventions: DEVICE: 5% Fluoride Varnish|DEVICE: 38% Silver diamine fluoride|DEVICE: Super Floss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Ombrabulin (AVE8062) in Combination With Taxane and Platinum in Patients With Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: ombrabulin (AVE8062)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT