pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Johns Hopkins Interactive eGuide to Colonoscopy and Ipad Office Education to Improve Colonoscopy
Status: COMPLETED
Conditions: Colon Cancer Screening|Colon Cancer Surveillance
Interventions: OTHER: eGuide to Colonoscopy and in office ipad education
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Postoperative Analgesic Efficacy of Continuous Wound Infusion After Laparoscopy
Status: UNKNOWN
Conditions: Benign Gynecologic Neoplasm
Interventions: DRUG: Ropivacaine|DRUG: 0.9% saline group|DEVICE: ON-Q Painbuster Silver Soaker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colesevelam Treatment for Impaired Fasting Glucose During Niacin Therapy
Status: COMPLETED
Conditions: Dyslipidemia|Hyperlipidemia|Hyperglycemia
Interventions: DRUG: Placebo|DRUG: Colesevelam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PRagmatic Trial Of Messaging to Providers About Treatment of Heart Failure in the Inpatient Setting
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: Best practice alert for the notification of patient HFrEF and recommended evidence-based medical therapies (NO drugs are being administered in this trial)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Difficult PIV Placement in the Pediatric ED
Status: NOT_YET_RECRUITING
Conditions: Pediatric ALL
Interventions: PROCEDURE: Difficult PIV placement personnel|PROCEDURE: US-trained PEM Fellows
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Research Study Looking at How a Single Dose of the Medicine Cagrilintide Works in Participants With Reduced Liver Function and in Healthy Participants With Normal Liver Function and How Cagrilintide is Absorbed and Used by the Body
Status: RECRUITING
Conditions: Hepatic Impairment|Healthy Volunteers
Interventions: DRUG: Cagrilintide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention Strategy for Pre-Menopausal Women at High Risk for Development of Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Placebo|DRUG: secoisolariciresinol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Safety Study of SGN-35T in Adults With Advanced Cancers
Status: RECRUITING
Conditions: Lymphoma, T-Cell, Cutaneous|Hodgkin Disease|Lymphoma, T-Cell, Peripheral|Lymphoma, Large-Cell, Anaplastic|Lymphoma, Large B-Cell, Diffuse|Lymphoma, Non-Hodgkin
Interventions: DRUG: SGN-35T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laryngoscope Types and The Cervical Motion
Status: COMPLETED
Conditions: Cervical Motion During Endotracheal Intubation
Interventions: OTHER: Macintosh type, Truview EVO2® type and Airtraq® type laryngoscopes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Investigation of Sacroiliac Fusion Treatment (INSITE)
Status: COMPLETED
Conditions: Degenerative Sacroiliitis|Sacroiliac Joint Disruption
Interventions: DEVICE: iFuse Implant System|OTHER: Non-surgical management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemotherapy Followed by Preoperative Chemoradiation in Resectable Squamous-cell Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Neoplasms|Squamous Cell Carcinoma|Concurrent Chemoradiotherapy
Interventions: DRUG: Paclitaxel|DRUG: Cisplatin|DRUG: Fluorouracil|RADIATION: chemoradiotherapy|PROCEDURE: Ivor Lewis esophagogastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Lamivudine in Patients With p53 Mutant Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer Metastatic
Interventions: DRUG: Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial on Trabectedin (ET-743) vs Clinician's Choice Chemotherapy in Recurrent Ovarian, Primary Peritoneal or Fallopian Tube Cancers of BRCA Mutated or BRCAness Phenotype Patients
Status: COMPLETED
Conditions: Ovarian Neoplasms
Interventions: DRUG: Trabectedin|DRUG: Pegylated Liposomal Doxorubicin|DRUG: Topotecan|DRUG: Gemcitabine|DRUG: Weekly Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Family-based Nutrition and Garden Intervention in Rural Guatemala
Status: COMPLETED
Conditions: Malnutrition|Dietary Modification
Interventions: DIETARY_SUPPLEMENT: Standard of care nutrition support|BEHAVIORAL: Home-based nutrition education|BEHAVIORAL: Home-based family gardening
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Pharmacokinetics, Pharmacodynamics, and Safety of Canagliflozin (JNJ-28431754) in Otherwise Healthy Obese Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Canagliflozin (JNJ-28431754)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Hand Injuries Rehabilitation Intervention Program That Incorporated Ethnic and Cultural Reference
Status: NOT_YET_RECRUITING
Conditions: Multiple Injuries of Hand (Disorder)
Interventions: PROCEDURE: Hand therapy Rehabilitation intervention program that incorporate cultural reference|PROCEDURE: Conventional Hand therapy Rehabilitation intervention program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Utility and Safety of Pramlintide in Subjects With Type 1 and Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus
Interventions: DRUG: pramlintide acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Treatment Outcomes of abobotulinumtoxinA and onabotulinumtoxinA Treatments in Real Life Practice in Toxin-naïve Adult Patients With Limb Spasticity.
Status: COMPLETED
Conditions: Spasticity Related to Any Cause Except Cerebral Palsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Kombucha Consumption on the Microbiome in Healthy Subjects
Status: COMPLETED
Conditions: Health Behavior
Interventions: DIETARY_SUPPLEMENT: Kombucha beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Optimizing Efficiency and Impact of Digital Health Interventions for Caregivers
Status: COMPLETED
Conditions: Family Caregivers|Insomnia|Sleep Initiation and Maintenance Disorders
Interventions: BEHAVIORAL: SHUTi (Sleep Healthy Using the Internet)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AMG 745 in Subjects With Age-associated Muscle Loss
Status: WITHDRAWN
Conditions: Age-associated Muscle Loss
Interventions: DRUG: AMG 745 0.3 mg/kg|DRUG: AMG 745 1.0 mg/kg|DRUG: AMG 745 3.0 mg/kg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis
Status: COMPLETED
Conditions: Aggressive Periodontitis
Interventions: BIOLOGICAL: Enamel Matrix Proteins|PROCEDURE: Open Flap Debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Application of Botulinum Toxin Type A in Salivary Glands in the Treatment of Drooling in Patients With Cerebral Palsy
Status: UNKNOWN
Conditions: Sialorrhea|Cerebral Palsy
Interventions: BIOLOGICAL: BOTULINUM NEUROTOXIN TYPE-A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of 18F-FFNP Breast PET/MRI
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: 18F-fluorofuranylnorprogesterone|DEVICE: Positron Emissions Tomography / Magnetic Resonance Imaging|DRUG: Anastrozole|OTHER: Blood Sampling|DRUG: Gadobenate dimeglumine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: AFTER: Altering Fat Through Estrogen and Raloxifene
Status: COMPLETED
Conditions: Postmenopause
Interventions: DRUG: conjugated estrogens|DRUG: Raloxifene|BEHAVIORAL: exercise plus mild caloric restriction for weight loss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Trial of a Limited Versus Traditional Oxygen Strategy During Resuscitation in Premature Newborns
Status: COMPLETED
Conditions: Prematurity|Oxidative Stress
Interventions: PROCEDURE: Titration of oxygen during newborn resuscitation in delivery room
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypertonic Resuscitation Following Severe Traumatic Brain Injury (TBI)
Status: TERMINATED
Conditions: Brain Injuries, Traumatic
Interventions: DRUG: 7.5% Hypertonic Saline in 6% Dextran-70 (HSD)|DRUG: 7.5% Hypertonic Saline (HS)|DRUG: 0.9% Normal Saline (NS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PK/PD, Long-term Safety and Efficacy of Tamsulosin Treatment in Children With Neurogenic Bladder
Status: COMPLETED
Conditions: Bladder, Neurogenic
Interventions: DRUG: tamsulosin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Internet-based Self-help Money Management Program Among Adult With Severe Mental Illness
Status: COMPLETED
Conditions: Severe Mental Illness
Interventions: BEHAVIORAL: Internet-based self-help money management program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Classical Prosthesis and Silicone Prosthesis
Status: COMPLETED
Conditions: Traumatic Amputation
Interventions: OTHER: the effects of classical Chopart prosthesis on socket comfort, satisfaction level and quality of life in patients with unilateral Chopart amputation.|OTHER: the effects of silicone prosthesis on socket comfort, satisfaction level and quality of life in patients with unilateral Chopart amputation.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Home-based Intervention to Test and Start
Status: UNKNOWN
Conditions: HIV|HIV Testing|Linkage to Care
Interventions: BEHAVIORAL: micro-incentive|BEHAVIORAL: EPIC-HIV|BEHAVIORAL: micro-incentive and EPIC-HIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Monthly Injectable BUP for MA Use Disorder (MURB) Trial
Status: TERMINATED
Conditions: Methamphetamine-dependence
Interventions: DRUG: Buprenorphine injection (BUP-Inj)|OTHER: Placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Utility of Long-acting Local Anesthetic Agents in Reducing Post-operative Opioid Requirements Following Rhinoplasty
Status: COMPLETED
Conditions: Pain, Postoperative|Local Anesthetic
Interventions: DRUG: marcaine bupivacaine|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Safety and Efficacy of Pimavanserin in Patients With Parkinson's Disease Psychosis
Status: COMPLETED
Conditions: Parkinson's Disease Psychosis
Interventions: DRUG: pimavanserin tartrate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Dalpiciclib Plus Endocrine Therapy in HR-positive / HER2-negative Advanced Breast Cancer Patients With Visceral Crisis
Status: NOT_YET_RECRUITING
Conditions: Advanced Breast Cancer
Interventions: DRUG: Dalpiciclib in combination with endocrine therapy by Physicians choice
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brown Adipose Tissue Activity and Energy Metabolism in Cachexia
Status: COMPLETED
Conditions: Cachexia|Neoplasms|Pulmonary Disease, Chronic Obstructive|Pancreatic Neoplasms
Interventions: RADIATION: 18F-FDG PET-MRI-imaging|RADIATION: DXA scanning|PROCEDURE: Abdominal subcutaneous adipose tissue biopsy|PROCEDURE: Blood sampling|OTHER: Indirect calorimetry|DEVICE: Accelerometry|OTHER: Double-labeled water
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Engineering an Online STI Prevention Program
Status: COMPLETED
Conditions: Sexual Behavior|Alcohol Consumption|Sexually Transmitted Diseases
Interventions: BEHAVIORAL: Knowledge alone|BEHAVIORAL: Self-efficacy alone|BEHAVIORAL: Perceived benefits alone|BEHAVIORAL: Perceived benefits and self-efficacy|BEHAVIORAL: Injunctive norms|BEHAVIORAL: Injunctive norms and self-efficacy|BEHAVIORAL: Injunctive norms and perceived benefits|BEHAVIORAL: Injunctive norms, perceived benefits, and self-efficacy|BEHAVIORAL: Descriptive norms alone|BEHAVIORAL: Descriptive norms and self-efficacy|BEHAVIORAL: Descriptive norms and perceived benefits|BEHAVIORAL: Descriptive norms,perceived benefits,self-efficacy|BEHAVIORAL: Descriptive and injunctive norms|BEHAVIORAL: Descriptive norms, injunctive norms,self-efficacy|BEHAVIORAL: Descriptive and injunctive norms, benefits|BEHAVIORAL: Descriptive and injunctive norms, benefits,efficacy|BEHAVIORAL: Expectancies alone|BEHAVIORAL: Expectancies and self-efficacy|BEHAVIORAL: Expectancies and Perceived Benefits|BEHAVIORAL: Expectancies, perceived benefits, self-efficacy|BEHAVIORAL: Expectancies and injunctive norms|BEHAVIORAL: Expectancies, injunctive norms, and self-efficacy|BEHAVIORAL: Expectancies, injunctive norms, benefits|BEHAVIORAL: Expectancies, injunctive norms, benefits, efficacy|BEHAVIORAL: Expectancies and descriptive norms|BEHAVIORAL: Expectancies, descriptive norms, and self-efficacy|BEHAVIORAL: Expectancies, descriptive norms, and benefits|BEHAVIORAL: Expectancies,descriptive norms, benefits, efficacy|BEHAVIORAL: Expectancies, descriptive and injunctive norms|BEHAVIORAL: Expectancies, descr& injun norms, efficacy|BEHAVIORAL: Expectancies, desc & injun norms, benefits|BEHAVIORAL: Expectancies,desc & injun norms,benefits,efficacy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Prophylactic Trial of Omega-3 Polyunsaturated Fatty Acids in Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Depression
Interventions: DIETARY_SUPPLEMENT: Smoothie 1g Eicosapentaneoic Acid (EPA) and 1g Docoshaexanoic Acid (DHA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Myocardial Protection With Multiport Antegrade Cold Blood Cardioplegia
Status: COMPLETED
Conditions: Coronary Artery Bypass Surgery
Interventions: PROCEDURE: multiport antegrade cardioplegia|PROCEDURE: Aortic root antegrade cardioplegia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Efficacy and Safety of Alefacept in Kidney Transplant Recipients
Status: COMPLETED
Conditions: De Novo Kidney Transplantation
Interventions: DRUG: Alefacept|DRUG: placebo|DRUG: Tacrolimus|DRUG: Mycophenolate Mofetil|DRUG: Steroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Repetitive Transcranial Magnetic Stimulation of the DMPFC for Anorexia and Bulimia: an Open-Label Case Series
Status: COMPLETED
Conditions: Bulimia Nervosa|Anorexia Nervosa
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bradykinin Receptor Antagonism During Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Cardiopulmonary Bypass|Inflammation|Fibrinolysis|Surgery
Interventions: DRUG: HOE 140|DRUG: Aminocaproic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nitrites in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Acute ST Elevation Myocardial Infarction
Interventions: DRUG: sodium nitrite|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Efficacy of Stereotactic Intracavitary Instillation of 90Yttrium Colloid
Status: COMPLETED
Conditions: Neuroepithelial Cyst
Interventions: RADIATION: Yttrium90
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study To Evaluate The Performance And Safety Of Favipiravir in COVID-19
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Favipiravir|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Performance of the PicoWayTM Picosecond Fractional Laser for Wrinkles Reduction
Status: UNKNOWN
Conditions: Unwanted Wrinkles
Interventions: DEVICE: PicoWayTM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Simplified Antiretroviral Treatment Strategies in HIV Infected Children Treated by Antiretroviral (ARV) Before One Year of Age
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: AZT-3TC-LPV/r twice a day|DRUG: ABC-3TC-EFV once a day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Placebo-Controlled, Two-Part Study, Oral Dose to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of CNTX-6970 in Healthy Subjects
Status: COMPLETED
Conditions: Chronic Pain|Nociceptive Pain
Interventions: DRUG: CNTX-6970|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing the Frequency of Follow up and Task Sharing in the Treatment of Uncomplicated Severe Acute Malnutrition
Status: COMPLETED
Conditions: Severe Acute Malnutrition
Interventions: OTHER: Standard weekly visits|OTHER: Monthly visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Combined Pulsed-field Ablation (PFA) and Left Atrial Appendage Occlusion Using Watchman Flx or Amulet
Status: ENROLLING_BY_INVITATION
Conditions: Combined Pulsed-field Ablation (PFA)
Interventions: DEVICE: Combined Pulsed-field Ablation (PFA) + Left Atrial Appendage Occlusion (LAAO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug-Drug Interaction Study Evaluating the Combination of IDX320 and IDX184 in Healthy Participants (MK-6844-002)
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: IDX320|DRUG: IDX184|DRUG: IDX184 placebo|DRUG: IDX320 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pressure Recording Analytical Method Parameters and Their Relationship With Hypotension in Hypertensive Patients
Status: NOT_YET_RECRUITING
Conditions: Cardiovascular Diseases|Surgery|Hypotension|Hypotension on Induction|Hypotension During Surgery
Interventions: DIAGNOSTIC_TEST: Passive leg raising
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Feasibility Study of Adjuvant Treatment With S-1 and Oxaliplatin in Patients With Resectable Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: S-1 and Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Median Effective Dose of Esketamine Pretreatment to Prevent Sufentanil-induced Cough
Status: NOT_YET_RECRUITING
Conditions: Sufentanil|Esketamine
Interventions: DRUG: Esketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Recurrent Ependymoma|Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Recurrent Glioma|Recurrent Hepatoblastoma|Recurrent Kidney Wilms Tumor|Recurrent Langerhans Cell Histiocytosis|Recurrent Malignant Germ Cell Tumor|Recurrent Malignant Glioma|Recurrent Malignant Solid Neoplasm|Recurrent Medulloblastoma|Recurrent Neuroblastoma|Recurrent Non-Hodgkin Lymphoma|Recurrent Osteosarcoma|Recurrent Rhabdoid Tumor|Recurrent Rhabdomyosarcoma|Recurrent Soft Tissue Sarcoma|Refractory Ependymoma|Refractory Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Refractory Glioma|Refractory Hepatoblastoma|Refractory Langerhans Cell Histiocytosis|Refractory Malignant Germ Cell Tumor|Refractory Malignant Glioma|Refractory Malignant Solid Neoplasm|Refractory Medulloblastoma|Refractory Neuroblastoma|Refractory Non-Hodgkin Lymphoma|Refractory Osteosarcoma|Refractory Primary Central Nervous System Neoplasm|Refractory Rhabdoid Tumor|Refractory Rhabdomyosarcoma|Refractory Soft Tissue Sarcoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration and Biopsy|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|DRUG: Larotrectinib Sulfate|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Radionuclide Imaging|PROCEDURE: X-Ray Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antibody Production in Immune Disorders
Status: TERMINATED
Conditions: Primary Immune Deficiency
Interventions: BIOLOGICAL: Pneumovax|BIOLOGICAL: Rabavert|BIOLOGICAL: Prevnar|BIOLOGICAL: Tetanus diphtheria toxoid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BKM120 in Cancers With PIK3CA Activating Mutations
Status: WITHDRAWN
Conditions: Lung Cancer|Breast Cancer|Colorectal Cancer|Cholangiocarcinoma|Solid Tumors
Interventions: DRUG: BKM120
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SHR-2017 Injection in Postmenopausal Women
Status: RECRUITING
Conditions: Osteoporosis
Interventions: DRUG: SHR-2017 injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chlorzoxazone in Hip and Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis of Hip|Osteoarthritis, Knee
Interventions: DRUG: chlorzoxazone|DRUG: Placebo|PROCEDURE: THA|PROCEDURE: TKA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Papaverine vs Heparin for Peripheral Arterial Catheter Patency in Pediatric Patients
Status: COMPLETED
Conditions: Pediatrics|Anesthesia|Vasospasm
Interventions: DRUG: Papaverine|DRUG: Heparin|DRUG: Rescue papaverine, as needed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Artificial Intelligence Empowered Anesthesia Ultrasound Guided Regional Anesthesia Training
Status: NOT_YET_RECRUITING
Conditions: Ultrasound-guided Regional Anesthesia
Interventions: DEVICE: Artificial intelligence empowers anesthesia with ultrasound assistance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Utility of CYP2D6 Genotyping to Improve the Efficacy and Safety of Tramadol
Status: RECRUITING
Conditions: Post-surgical Pain|Pain, Acute|Postoperative Pain
Interventions: DRUG: The patients in experimental group will be genotyped before surgery and treatment will be prescribed according to the CYP2D6 phenotype
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3b, Open-Label, Safety and Efficacy Study of Rotigotine as Add-On Therapy With Low Doses of Pramipexole or Ropinirole in Patients With Advanced Parkinson's Disease
Status: COMPLETED
Conditions: Advanced Parkinson's Disease
Interventions: DRUG: Rotigotine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Hypolipemic and Antidiabetic Treatment on Cytokines
Status: UNKNOWN
Conditions: Diabetes|Dyslipidemia|Inflammation|Cytokines
Interventions: DRUG: Metformin 1000mg, simvastatin 10mg and fenofibrate 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of The Personalized Patient Engagement Plan on Diabetes Management
Status: COMPLETED
Conditions: Type 2 Diabetes|Patient Engagement|Self Efficacy|Adherence, Patient
Interventions: BEHAVIORAL: PHEinAction-Personalized Patient Engagement Plan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Talabostat + Docetaxel Versus Docetaxel in Stage IIIB/IV Non-Small Cell Lung Cancer (NSCLC) After Failure of Platinum-Based Chemotherapy
Status: TERMINATED
Conditions: Carcinoma, Non-Small Cell Lung
Interventions: DRUG: talabostat mesylate|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Cross-over Comparison of the V60 System to Other Bi-Level Noninvasive Ventilators
Status: COMPLETED
Conditions: Respiratory Insufficiency|Respiratory Failure
Interventions: DEVICE: Use of the V60 Mask Ventilator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Exercise for Colorectal Cancer Patients After Transanal Total Mesorectal Excision
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: OTHER: pelvic floor muscle exercise before stoma closure|OTHER: pelvic floor muscle exercise after stoma closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Aiming Towards Evidence Based Interpretation of Cardiac Biomarkers in Patients Presenting With Chest Pain Using Point of Care Assays
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DIAGNOSTIC_TEST: Troponin I (Siemens VTli) 0/1 hour algorithm|DIAGNOSTIC_TEST: Troponin T (Roche Diagnostics) 0/1 hour ESC algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dry Needling and Stretching vs. Stretching Alone on Hamstring Flexibility in Patients With Knee Pain
Status: COMPLETED
Conditions: Mobility Limitation
Interventions: PROCEDURE: Dry Needling|OTHER: Sham Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Muscle Energy Technique and Foam Roller Self Myofascial Release in Two-wheeler Riders With Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low-back Pain
Interventions: OTHER: Muscle energy technique|OTHER: Self-myofascial release technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dopamine and Norepinephrine in Shock Patients
Status: COMPLETED
Conditions: Shock
Interventions: DRUG: dopamine versus norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of MEDI4736 in Combination With Olaparib in Patients With Advanced Solid Tumors.
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian|Breast|SCLC|Gastric Cancers
Interventions: DRUG: Olaparib|DRUG: MEDI4736|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Pitavastatin or Combination of Pitavastatin and Ezetimibe on Glucose Metabolism Compared to AtoRvastatin in atheroscLerotic Cardiovascular Disease Patients With Metabolic Syndrome: The EZ-PEARL Randomized Trial
Status: RECRUITING
Conditions: Dyslipidemias|Atherosclerotic Cardiovascular Disease
Interventions: DRUG: Pitavastatin|DRUG: Pitavastatin plus Ezetemibe|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulse-based Foods for Alleviation of Negative Consequences of Sedentary Behaviour
Status: COMPLETED
Conditions: Insulin Sensitivity
Interventions: DIETARY_SUPPLEMENT: Pulse-based diet|DIETARY_SUPPLEMENT: Regular diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Exploring Safety & Clinical Benefit of Anti-Influenza Immunoglobulin Intravenous in Hospitalized Adults With Influenza A
Status: COMPLETED
Conditions: Influenza A H3N2|Influenza A H1N1
Interventions: BIOLOGICAL: FLU-IGIV|OTHER: Placebo for FLU-IGIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Stage 2-3A Breast Cancer With Positive Lymph Nodes
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: paclitaxel|DRUG: tamoxifen citrate|PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study Bevacizumab Biosimilar (BEVZ92) Versus Bevacizumab (AVASTIN®) in First-line Treatment mCRC Patients
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer (mCRC)
Interventions: DRUG: Bevacizumab biosimilar (BEVZ92)|DRUG: Avastin® (bevacizumab, reference product)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Probiotics to Aid in Weight Loss
Status: COMPLETED
Conditions: Weight Loss
Interventions: DIETARY_SUPPLEMENT: Probiotics|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate and Sunitinib in Treating Patients With Gastrointestinal Stromal Tumors
Status: TERMINATED
Conditions: Gastrointestinal Stromal Tumor
Interventions: DRUG: imatinib mesylate|DRUG: sunitinib malate|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FOLFOX Followed by FOLFIRI or Reverse Sequence Treatment in Advanced Gastric Cancer (AGC)
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: irinotecan, oxaliplatin|DRUG: oxaliplatin, irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Characterisation Protocol for COVID-19 in People Living With HIV
Status: UNKNOWN
Conditions: Adult Patients Living With HIV (PLWHIV) With Confirmed Infection With SARS-CoV-2 Since 1st January 2020
Interventions: BIOLOGICAL: Biological collection (patients co infected HIV Sras-CoV-2)|OTHER: Auto-questionnaires (patients co infected HIV Sras-CoV-2)|OTHER: Qualitative interviews (in 40 patients : 20 with COVID-19 and 20 without COVID-19)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase I : Cediranib in Combination With Lomustine Chemotherapy in Recurrent Malignant Brain Tumour
Status: COMPLETED
Conditions: Recurrent Glioblastoma|Brain Tumor
Interventions: DRUG: Cediranib|DRUG: Lomustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PCORI-1306-02918 Evaluation of Parent-based Programs to Support Children After Traumatic Injury
Status: COMPLETED
Conditions: Psychological Trauma|Depression|Coping
Interventions: BEHAVIORAL: Link for Injured Kids|OTHER: So you've been in an accident
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study in Healthy Female Participants Investigating the Effect of TMC435 on the Pharmacokinetics of the Synthetic Hormones of the Oral Contraceptive Ovysmen
Status: COMPLETED
Conditions: Hepatitis C Virus
Interventions: DRUG: TMC435|DRUG: Ovysmen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sinomenine Versus Glucocorticoid for Knee OA
Status: NOT_YET_RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DRUG: Sinomenine|DRUG: Glucocorticoid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Automatic Ventilation in Prehospital Resuscitation on OHCA
Status: RECRUITING
Conditions: Out-Of-Hospital Cardiac Arrest
Interventions: DEVICE: Automatic ventilation|DEVICE: Manual ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Participants With Chronic Rhinosinusitis With Nasal Polyps
Status: RECRUITING
Conditions: Chronic Rhinosinusitis With Nasal Polyps
Interventions: DRUG: Verekitug (UPB-101)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pioglitazone Protects Diabetes Mellitus (DM) Patients Against Re-Infarction (PPAR Study)
Status: TERMINATED
Conditions: Diabetes Mellitus|Myocardial Infarction
Interventions: DRUG: pioglitazone|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Fructo-oligosaccharides and Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Fructo-oligosaccharides|DIETARY_SUPPLEMENT: Maltodextrins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Preliminary Study of Peel Force and Discomfort of Removal of Adhesive Barriers in Normal and Peristomal Skin
Status: COMPLETED
Conditions: Dermatologic Complications
Interventions: DEVICE: Control Abdominal Skin|DEVICE: Peristomal Abdominal Skin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Closed-loop in Adults With Type 2 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes Treated With Insulin
Interventions: DEVICE: CamAPS HX|OTHER: Standard insulin therapy with glucose sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Accuracy of Optic Biopsies Versus Conventional Biopsies for the Diagnosis of Superficial Bladder Neoplasia
Status: UNKNOWN
Conditions: Bladder Cancer
Interventions: DEVICE: Confocal LASER Endomicroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Locally Advanced or Metastatic Solid Tumors|NSCLC|HNSCC|Melanoma|TNBC|Esophageal Cancer|Gastric Cancer|Cervical Cancer|Urothelial Carcinoma|Clear Cell RCC|HCC
Interventions: DRUG: RO7502175|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Melatonin on Postoperative Pain Reduction After Orthognathic Surgery
Status: SUSPENDED
Conditions: Effect of Drugs
Interventions: DRUG: Melatonin|DRUG: Dexamethasone Sodium Sulphate 4mg/1mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EARLY TAVR: Evaluation of TAVR Compared to Surveillance for Patients With Asymptomatic Severe Aortic Stenosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Diseases|Aortic Stenosis, Severe
Interventions: DEVICE: Edwards SAPIEN 3 / SAPIEN 3 Ultra THV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficiency of Amnion Graft to Prevent Intrauterine Adhesions After Hysteroscopic Surgery
Status: UNKNOWN
Conditions: Intrauterine Adhesions
Interventions: PROCEDURE: Uterine application of amnion membrane|DEVICE: Foley balloon|DRUG: Femoston
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study to Test Different Ways to Measure the Effect of Atomoxetine on Impulsive Behavior in Young Adults With Attention Deficit Hyperactivity Disorder (ADHD)
Status: RECRUITING
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Zentiva®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Giving Reduced Fluid in Children After Trauma
Status: RECRUITING
Conditions: Critical Illness|Pediatrics|General Surgery|Fluid Therapy|Wounds and Injuries
Interventions: OTHER: Balanced crystalloid solution volume administration|OTHER: Packed Erythrocytes Units, Blood Product Unit volume|OTHER: Plasma volume|OTHER: Platelets volume
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Peptide Receptor Radionuclide Therapy (PRRT) With 177Lu-DOTATATE in Advanced Gastro-entero Pancreatic Neuroendocrine Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Neuroendocrine Tumors
Interventions: DRUG: 177Lu-DOTATATE 25.9 GBq activity|DRUG: 177Lu-DOTATATE 18.5 GBq activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the CR Plug (Allograft) for the Treatment of a Cartilage Injury in the Knee.
Status: TERMINATED
Conditions: Knee Injury
Interventions: PROCEDURE: Placement of allograft CR Plug in primary injury site
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety of GSK1325756 in Elderly Subjects and Adult Subjects of in the Fed and Fasted States and in the Presence of a Proton Pump Inhibitors
Status: COMPLETED
Conditions: Nutritional Status
Interventions: DRUG: GSK1325756|DRUG: GSK1325756
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PERFECT Project - Part 1 - Study 1
Status: COMPLETED
Conditions: Diabetes Prevention|Obesity Prevention
Interventions: OTHER: Control|OTHER: Small particle size pea flour|OTHER: Large particle size pea flour|OTHER: Lentil flour|OTHER: Navy bean flour|OTHER: Pinto bean flour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Safety and Efficacy of Wharton's Jelly Compared to Hyaluronic Acid and Saline for Knee Osteoarthritis.
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: BIOLOGICAL: Umbilical Cord-derived Wharton's Jelly|DEVICE: Hyaluronic acid|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Dexmedetomidine and Haloperidol in Patients With Intensive Care Unit (ICU)-Associated Agitation and Delirium
Status: COMPLETED
Conditions: Delirium|Agitation|Ventilator Weaning|Respiration, Artificial|Intensive Care
Interventions: DRUG: dexmedetomidine|DRUG: haloperidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for Functional Dyspepsia: a Functional Magnetic Resonance Imaging (fMRI) Study
Status: COMPLETED
Conditions: Functional Dyspepsia
Interventions: OTHER: acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Combination of Treatment of Reginmune Capsule and Immunofree Tablets in the Treatment of Mild to Moderate COVID-19 Patients
Status: COMPLETED
Conditions: Treatment of Covid-19 Virus Infection
Interventions: COMBINATION_PRODUCT: Immunofree tablets and Reginmune capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab, Binimetinib, and Bevacizumab in Patients With Refractory Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer|Metastatic Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Bevacizumab|DRUG: Binimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neural Correlates of Knee Sensorimotor Control in Patients With Patellofemoral Pain Syndrome
Status: COMPLETED
Conditions: Patellofemoral Pain Syndrome|Patellofemoral Pain
Interventions: OTHER: Neural Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: SAFE-LCD Trial, for Insulin-treated Adults Living With Type 2 Diabetes
Status: RECRUITING
Conditions: Type 2 Diabetes Treated With Insulin|Diet Habit
Interventions: OTHER: Oviva programme|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluating the Hypothesized Mechanism of Action of N-acetylcysteine for Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder|Bipolar I Disorder|Bipolar II Disorder
Interventions: DRUG: N-Acetyl cysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT