pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI)
Status: COMPLETED
Conditions: Severe Traumatic Brain Injury
Interventions: DEVICE: Management protocol based on pBrO2 and ICP values.|DEVICE: Management protocol based on ICP values only.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CellCept® Dose Adjustment Versus Fixed Dose (Standard Care) in Renal Transplant Recipients
Status: UNKNOWN
Conditions: Renal Transplant
Interventions: DRUG: Mycophenolate mofetil (CellCept® )|DRUG: Mycophenolate mofetil (CellCept® )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Edoxaban Versus Edoxaban With antiPlatelet Agent In Patients With Atrial Fibrillation and Chronic Stable Coronary Artery Disease
Status: COMPLETED
Conditions: Atrial Fibrillation|Coronary Artery Disease|Stable Angina|Stable Chronic Angina
Interventions: DRUG: Edoxaban Monotherapy|DRUG: Edoxaban plus Single Antiplatelet Agent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial LED Therapy for Severe Acute Traumatic Brain Injury
Status: UNKNOWN
Conditions: Diffuse Axonal Brain Injury|Traumatic Brain Injury
Interventions: DEVICE: Transcranial LED Therapy (Active coil helmet)|DEVICE: Transcranial LED Therapy (Inactive coil helmet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Bioavailability of Diclofenac Dermal Products
Status: COMPLETED
Conditions: Bioavailability
Interventions: DRUG: Diclofenac Epolamine Patch|DRUG: diclofenac sodium solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Methadone Versus Placebo in Spine Fusion
Status: WITHDRAWN
Conditions: Postoperative Pain
Interventions: DRUG: Methadone|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Plasma cfDNA Testing Guiding the Treatment Decisions of DLBCL
Status: NOT_YET_RECRUITING
Conditions: Lymphoma, Large B-Cell, Diffuse
Interventions: DIAGNOSTIC_TEST: cfDNA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Use of a Probiotic Supplement to Prevent Asthma in Infants
Status: COMPLETED
Conditions: Asthma
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Topical Aluminium Chloride vs OnabotulinumtoxinA Intradermal Injections in Residual Limb Hyperhidrosis (Lower Limbs)
Status: COMPLETED
Conditions: Hyperhidrosis|Residual Limbs
Interventions: DRUG: OnabotulinumtoxinA|OTHER: Topical Aluminium Chloride (cosmetic product)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Rituximab in Progressive Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis, Chronic Progressive|Nervous System Diseases
Interventions: DRUG: Rituximab IT|DRUG: methylprednisolone IV|DRUG: Rituximab IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Filtek™ Bulk Fill Posterior Restorative in Class I and II Restorations
Status: COMPLETED
Conditions: Dental Caries Class I|Dental Caries Class II
Interventions: DEVICE: Filtek™ Bulk Fill Posterior Restorative|DEVICE: Filtek™ Z350XT Universal Restorative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Second-line Irinotecan and Capecitabine Versus Irinotecan for Gemcitabine and Cisplatin Refractory Biliary Tract Cancer
Status: COMPLETED
Conditions: Biliary Tract Neoplasms
Interventions: DRUG: Irinotecan|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Fentanyl Soaked Nasal Packs on Postoperative Pain in Nasal Surgeries.
Status: NOT_YET_RECRUITING
Conditions: Postoperative Pain
Interventions: DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of MORAb-022 in Healthy and Rheumatoid Arthritis Subjects
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: MORAb-022|DRUG: MORAb-022
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Three Different Techniques for Tracheal Intubation Via Supraglottic Airway Devices
Status: COMPLETED
Conditions: Tracheal Intubation
Interventions: PROCEDURE: Tracheal intubation through "Fastrach" - Group A|PROCEDURE: Tracheal intubation through "I-gel" - Group B|PROCEDURE: Tracheal intubation through "Protector" - Group C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Hemophilia Inhibitor Prevention Trial
Status: TERMINATED
Conditions: Hemophilia A Without Inhibitor
Interventions: DRUG: Eloctate Injectable Product|DRUG: Emicizumab Injection [Hemlibra]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Venetoclax Combining Chidamide and Azacitidine (VCA) in the Treatment of R/R AML
Status: RECRUITING
Conditions: Leukemia, Myeloid, Acute|Relapsed Adult AML|Refractory Leukemia
Interventions: DRUG: venetoclax combining chidamide and azacitidine (VCA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Consolidation Versus Induction Chemotherapy in Total Neoadjuvant Therapy of Rectal Cancer With High Risk for Recurrence
Status: RECRUITING
Conditions: Locally Advanced Rectal Cancer
Interventions: OTHER: consolidation chemotherapy|OTHER: induction chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noise-Enhanced Sensory Function in Elders at Risk for Falls
Status: UNKNOWN
Conditions: Aging|Somatosensory Deficit
Interventions: DEVICE: Vibrating Insoles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Pharmacokinetics of Two Formulations of MK-1006 (MK-1006-010 AM1)(COMPLETED)
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: MK-1006 DFC|DRUG: MK-1006 FCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Lma-Protector With Endotracheal Tube: Evaluation of Respiratory Mechanical Parameters During Controlled Ventilation & Possibility of Pulmonary Aspiration
Status: RECRUITING
Conditions: Mechanical Ventilation
Interventions: DEVICE: LMA Protector|DEVICE: Endotracheal tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Extension Study Of Subjects From Study A3921030 For The Prevention Of Acute Rejection In Kidney Transplant Patients
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: Cyclosporine|DRUG: CP-690,550|DRUG: CP-690,550
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Time for a Diagnostic Paradigm Shift From STEMI/NSTEMI to OMI/NOMI
Status: NOT_YET_RECRUITING
Conditions: Myocardial Infarction|Myocardial Ischemia|Acute Coronary Syndrome|Diagnosis|Morality
Interventions: PROCEDURE: Early intervention for OMI|PROCEDURE: Standard early intervention for STEMI|PROCEDURE: Standard delayed intervention for NSTEMI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetic Interactions in Combination Treatment of Valproic Acid and Ertapenem in Normal Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Valproic acid and Ertapenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: SynCardia 70cc TAH-t for Destination Therapy (DT)
Status: UNKNOWN
Conditions: Life-threatening|Biventricular Heart Failure|Ineligible for Cardiac Transplant
Interventions: DEVICE: 70cc TAH-t for Destination Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Ultrasound in Liver Stiffness and Fat Quantification
Status: RECRUITING
Conditions: Liver Disease Chronic|Fibrosis, Liver|Liver Steatoses|Liver Fat|NAFLD|NASH With Fibrosis|Hepatitis
Interventions: DIAGNOSTIC_TEST: Ultrasound based Elastography and fat quantification
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Thorough QT Study of Aticaprant (JNJ-67953964) in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Aticaprant Supratherapeutic Dose|DRUG: Aticaprant Therapeutic Dose|DRUG: Placebo|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Clinical Study of Intermittent High Dose of Icotinib in Combination With Docetaxel to Treat Lung Cancer
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Icotinib|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A.L.P.S. Clavicle Plating System PMCF
Status: ENROLLING_BY_INVITATION
Conditions: Clavicle Fracture|Clavicle Injury
Interventions: DEVICE: Clavicle open reduction and internal fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Liberal and Restrictive Fluids on Nausea-vomiting
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: OTHER: Liberal Fluid Grubu|OTHER: Restrictive Fluid Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of TQB2928 in Combination With a Third-Generation Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI) in Patients With Advanced Non-Small Cell Lung Cancers
Status: NOT_YET_RECRUITING
Conditions: Advanced Non-small Cell Lung Cancer
Interventions: DRUG: TQB2928 injection + Almonertinib Mesilate Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Low Carb Diet on Erectile Function and Serem Testosterone in Men With Metabolic Syndrome
Status: COMPLETED
Conditions: Testosterone Deficiency|Metabolic Syndrome|Diet Modification
Interventions: BEHAVIORAL: low carb diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Natalizumab in the Treatment of Rheumatoid Arthritis in Subjects Receiving Methotrexate
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: natalizumab|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Bioimpedance Spectroscopy Versus Tape Measure in Prevention of Lymphedema (PREVENT)
Status: COMPLETED
Conditions: Lymphedema
Interventions: DEVICE: 23-32 mmHg compression sleeve with gauntlet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Non-syndromic Inherited Anomalies of Mineralized Tooth Tissues: a Whole Exome Study to Identify New Pathogenic Variants
Status: UNKNOWN
Conditions: Amelogenesis Imperfecta|Dentinogenesis Imperfecta|Dentin Anomalies
Interventions: BIOLOGICAL: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Investigate the Cardiovascular Safety of Apricitabine in Healthy Subjects
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: apricitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Flecainide Acetate Inhalation Solution for Cardioversion of Recent-Onset, Symptomatic Atrial Fibrillation
Status: TERMINATED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DRUG: FlecIH-103
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Randomized, Placebo-controlled, Multiple Dose Escalation Study to Investigate Safety, Pharmacokinetics, and Pharmacodynamics of SHR0534 in Chinese Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Type 2 Diabetic Patients
Interventions: DRUG: SHR0534|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Meta-Cognitive Training (EMC) in People With Psychosis of Brief Evolution.
Status: COMPLETED
Conditions: Psychosis
Interventions: BEHAVIORAL: Meta-cognitive Training|BEHAVIORAL: Psychoeducational group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maxim® Knee Pop-Top® Tibia vs. Regular Maxim® Knee Tibia
Status: TERMINATED
Conditions: Osteoarthritis|Rheumatoid Arthritis|Traumatic Arthritis
Interventions: DEVICE: Maxim® Knee System with Removable Molded Polyethylene Tibia|DEVICE: Regular Maxim® Knee System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Influence on Serotonin in Cognitive and Emotional Functioning in Women
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: lumiVida™|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tranexamic Acid in Major Vascular Surgery
Status: COMPLETED
Conditions: Blood Loss, Surgical
Interventions: DRUG: tranexamic acid diluted in 100 ml of saline solution (loading dose)|DRUG: tranexamic acid undiluted (continous infusion)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Nutrition for the Colorectal Cancer Patients Receiving Chemotherapy-randomized Controlled Study
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: Premium Amino Acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Research of Femtosecond Laser-Assisted Cataract Surgery
Status: COMPLETED
Conditions: Cataracts
Interventions: PROCEDURE: femtosecond laser-assisted cataract surgery|PROCEDURE: conventional phacoemulsification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of AZR-MD-001 in Patients With Meibomian Gland Dysfunction (MGD)
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction
Interventions: DRUG: AZR-MD-001 Active|DRUG: AZR-MD-001 Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Different Safety Profile of Risperidone and Paliperidone Extended-release
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: risperidone|DRUG: paliperidone ER|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Assessment of the Diagnostic Role of Serum Insulin-like Growth Factor Binding Protein-3 as a Potential Biomarker for Colorectal Cancer (CRC) in Egypt
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer
Interventions: DIAGNOSTIC_TEST: evaluation of diagnostic importance of insulin like growth factor binding protein3 in patient with recently diagnosed as Colorectal cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Efficacy, Safety and Pharmacokinetics of EYU688 in Patients With Dengue Fever
Status: ACTIVE_NOT_RECRUITING
Conditions: Dengue
Interventions: DRUG: EYU688|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: InvaplexAR-Detox and dmLT Adjuvant in the Netherlands and Zambia
Status: NOT_YET_RECRUITING
Conditions: Shigellosis|Bacillary Dysentery
Interventions: BIOLOGICAL: 2.5 μg InvaplexAR-Detox|BIOLOGICAL: 10 μg InvaplexAR-Detox|BIOLOGICAL: 0.1 μg of dmLT|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Anti T-lymphocyte Immunoglobulin With Post Transplant Cyclophosphamide to Prevent GVHD Post Allogeneic Transplantation
Status: RECRUITING
Conditions: Graft Versus Host Disease
Interventions: DRUG: Cyclophosphamide|DRUG: anti-human T-lymphocyte immunoglobulin (ATLG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: E. Coli Nissle 1917 - Suspension for Infection Prophylaxis
Status: COMPLETED
Conditions: Infections
Interventions: DRUG: EcN-Suspension|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Sildenafil in Preterm Preeclampsia
Status: WITHDRAWN
Conditions: Preterm Preeclampsia
Interventions: DRUG: Sildenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 10 Days of Theta Burst Stimulation as a Tool to Treat Cocaine Dependence
Status: COMPLETED
Conditions: Cocaine Dependence|Alcohol Dependence
Interventions: DEVICE: Real cTBS|DEVICE: Sham cTBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of XELOX Combined With Sintilimab and Lenvatinib in Advanced AFP-positive Gastric Cancer Patients
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Lenvatinib and Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Effectiveness of Newer Antipsychotics in Comparison With Conventional Antipsychotics in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Olanzapine|DRUG: Flupentixol|DRUG: Quetiapine|DRUG: Aripiprazole|DRUG: Haloperidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Favipiravir 200 mg Film Tablet (Pharma Plant, Turkey) Under Fasting Conditions
Status: UNKNOWN
Conditions: Bioequivalence
Interventions: DRUG: AVICOD 200 MG Film Tablet|DRUG: AVIGAN 200 MG Film Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Performance and Safety of the MARIAL® in Association With PPI Versus PPI Alone
Status: RECRUITING
Conditions: Gastroesophageal Reflux Disease (GERD)
Interventions: COMBINATION_PRODUCT: MARIAL® + PPI (generic Omeprazole)|DRUG: PPI alone (generic omeprazole)|DEVICE: MARIAL® alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CFTR Modulators and Gastrointestinal Complications
Status: COMPLETED
Conditions: Cystic Fibrosis|Gastrointestinal System Disease|Distal Intestinal Obstruction Syndrome|Pancreatic Enzyme Abnormality|Pancreatic Disease|Lung Diseases|Digestive System Disease
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mesenchymal Stem Cells for Immune Non-responder Patients With HIV Infection
Status: RECRUITING
Conditions: AIDS Virus|Disorder of Immune Reconstitution
Interventions: OTHER: normal saline|BIOLOGICAL: Mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Prospective Study of Standard Treatment of Graves Disease Iodine 131 and Prevention of Adverse Reactions
Status: UNKNOWN
Conditions: Hypothyroidism|Exophthalmos
Interventions: RADIATION: Iodine 131
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Interferon Lambda for Immediate Antiviral Therapy at Diagnosis in COVID-19
Status: COMPLETED
Conditions: Sars-CoV2|Covid-19
Interventions: DRUG: Peginterferon Lambda-1A|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: International Non-selection Study for ERA® Test in Patients With Previous Implantation Failures
Status: RECRUITING
Conditions: Infertility of Uterine Origin|Implantation Failure
Interventions: DIAGNOSTIC_TEST: Endometrial fluid and biopsy collection|DIAGNOSTIC_TEST: Endometrial fluid and biopsy collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vitamin D for Cognition in Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DIETARY_SUPPLEMENT: solubilized vitamin D3|DIETARY_SUPPLEMENT: medium chain triglyceride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Comparison of TAK-438 (Vonoprazan) to Lansoprazole in the Treatment of Duodenal Ulcer Participants With or Without Helicobacter Pylori Infection
Status: COMPLETED
Conditions: Duodenal Ulcer
Interventions: DRUG: TAK-438|DRUG: Lansoprazole|DRUG: TAK-438 Placebo|DRUG: Lansoprazole Placebo|DRUG: Bismuth-Containing Quadruple Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Tirzepatide on Progression of Coronary Atherosclerosis Using MDCT
Status: RECRUITING
Conditions: Type II Diabetes|Atherosclerosis
Interventions: DRUG: Tirzepatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Food Effect on Drug Availability, Pharmacokinetic (PK) Properties, Safety and Tolerability of Two Different Dose Combination Therapy of Saxagliptin/Dapagliflozin/Metformin Extended-release (XR) Against Individual Component Co-administration.
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: 2.5 mg Saxagliptin tablet|DRUG: 5 mg dapagliflozin / 1000 mg metformin XR tablet|DRUG: Triple FCDP - 2.5 mg saxagliptin / 5 mg dapagliflozin / 1000 mg metformin XR|DRUG: 5 mg saxagliptin|DRUG: 10 mg dapagliflozin / 1000 mg metformin XR tablet|DRUG: Triple FCDP - 5 mg saxagliptin / 10 mg dapagliflozin / 1000 mg metformin XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EF-39 PANOVA-4: Study of Tumor Treating Fields Concomitant With Atezolizumab, Gemcitabine and Nab-Paclitaxel as First-LineTreatment for Metastatic Pancreatic Ductal Adenocarcinoma
Status: RECRUITING
Conditions: Metastatic Pancreatic Ductal Adenocarcinoma
Interventions: DEVICE: Tumor Treating Fields|DRUG: Atezolizumab|DRUG: Gemcitabine|DRUG: nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of TD0025 (Rocket1h) for Treatment of Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: TD0025|DRUG: Sildenafil Citrate 50mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cortical Excitability Changes Induced by Retigabine: a Transcranial Magnetic Stimulation Study
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: retigabine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Topotecan in Treating Patients With Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cavity Cancer
Status: TERMINATED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Peritoneal Cavity Cancer
Interventions: DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Assessment of of Burst Wave Lithotripsy (BWL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Calculi|Ureteral Calculi
Interventions: DEVICE: Burst Wave Lithotripsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Intravenous Novantrone(R) in the Treatment of AIDS Related Kaposi's Sarcoma
Status: COMPLETED
Conditions: Sarcoma, Kaposi|HIV Infections
Interventions: DRUG: Mitoxantrone hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerance of Increased Doses of SHR-2106 Injection in Healthy Subjects
Status: ENROLLING_BY_INVITATION
Conditions: Kidney Transplantation
Interventions: DRUG: SHR-2106 injection or placebo|DRUG: SHR-2106 injection or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Impact of the Minimum Inhibitory Concentration and Susceptible Cut-off Points (CLSI, EUCAST, and Pharmacokinetics/Pharmacodynamics)in Prognosis of Bacteremia by Enterobacteriaceae
Status: COMPLETED
Conditions: Bacteremia by Enterobacteriaceae
Interventions: OTHER: Microbiological studies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase III Study of Botulax® to Treat Post Stroke Upper Limb Spasticity
Status: COMPLETED
Conditions: Stroke|Spasticity
Interventions: BIOLOGICAL: Botulinum toxin type A(Botulax®)|BIOLOGICAL: Botulinum toxin type A(Botox®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Dietary Intervention and Surgery on NAFLD (Non-Alcoholic Fatty Liver Disease)
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease|Non Alcoholic Fatty Liver|Bariatric Surgery Candidate|Obesity, Morbid
Interventions: PROCEDURE: Roux-en-Y Gastric Bypass (RYGB) surgery|PROCEDURE: Sleeve Gastrectomy (SG) surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BB-1701 in Previously Treated Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive or HER2-low Unresectable or Metastatic Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: BB-1701
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SGLT Inhibitors Versus DDP4 Inhibitors and Prostate in Patient With Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus|Prostatic Hyperplasia
Interventions: OTHER: International prostate symptom score|DIAGNOSTIC_TEST: Assessment of prostate volume|OTHER: Pittsburgh sleep quality Index|DIAGNOSTIC_TEST: Glycated hemoglobin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of no Pharmacokinetic Interaction Between Rosuvastatin 20mg and Ezetimibe10mg, Fixed Dose vs Individual Components
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rosuvastatin (20mg) /Ezetimibe (10mg) in fixed dose|DRUG: Rosuvastatin 20mg|DRUG: Ezetimibe 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study Looking at How Faster Aspart Injected in Double Concentration Works in the Body of People With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Faster Aspart 200 U/mL|DRUG: Faster aspart 100 U/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Applying Artificial Intelligence to the 12 Lead ECG for the Diagnosis of Pulmonary Hypertension: an Observational Study
Status: ENROLLING_BY_INVITATION
Conditions: Pulmonary Hypertension (Diagnosis)
Interventions: DIAGNOSTIC_TEST: Artificial Intelligence and Machine Learning technology
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Metabolic Adaptation to High-frequent Hypoglycaemia in Type 1 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Type1diabetes
Interventions: DRUG: insulin human|DRUG: Epinephrin|PROCEDURE: Muscle biopsy|PROCEDURE: Adipose tissue biopsy|DRUG: Glucagon|DEVICE: IPRO 2 Medtronic Minimed|PROCEDURE: 7 Tesla (7T) Magnetic Resonance Imaging|PROCEDURE: Indirect Calorimetry using Jaeger Oxycon Champion|PROCEDURE: Core temperature and thermography using Thermovision SC645|DEVICE: Freestyle Libre 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Acetaminophen in aSAH to Inhibit Lipid Peroxidation and Cerebral Vasospasm
Status: TERMINATED
Conditions: Aneurysmal Subarachnoid Hemorrhage|Cerebral Vasospasm
Interventions: DRUG: Placebos for acetaminophen and N-acetylcysteine|DRUG: APAP 1 gm every 6 hours and N-acetylcysteine placebo|DRUG: NAC IV infusion at 0.5 gm hourly and APAP placebo|DRUG: APAP 1 gm q6 hours, plus NAC IV infusion at 0.5 gm hourly|DRUG: APAP 1.5 gm q6 hours, plus NAC IV infusion at 0.5 gm hourly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pimecrolimus Cream 1% in Patients ≥ 3 Months of Age With Mild or Moderate Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Pimecrolimus Cream 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Neurobehavioural Mechanism of N-acetyl Cysteine (NAC) for Alcohol Dependence
Status: UNKNOWN
Conditions: Alcohol Dependence
Interventions: DRUG: NAC 2400mg/day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized Indicators for Predicting Response to SSRI Treatment in Major Depression (The PRISE-MD Study)
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Escitalopram|DRUG: Bupropion XL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Olmesartan Medoxomil in Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Cardiovascular Disease|Kidney Disease
Interventions: DRUG: Olmesartan medoxomil|DRUG: Placebo Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Magic Mouthwash Plus Sucralfate Versus Benzydamine Hydrochloride for the Treatment of Radiation-induced Mucositis
Status: COMPLETED
Conditions: Head and Neck Cancer|Mucositis
Interventions: DRUG: Combination of Magic Mouthwash Plus Sucralfate|DRUG: 0.15% Benzydamine HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Neuromodulation on Brain Electric Activity of Parkinson's Disease Patients
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: DEVICE: Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Measure the Difference in All-cause Hospitalizations for Participants Who Are Using Abilify MyCite Versus Virtual Matched Controls in Adults With Schizophrenia, Bipolar 1 Disorder, and Major Depressive Disorder
Status: TERMINATED
Conditions: Schizophrenia|Bipolar 1 Disorder|Major Depressive Disorder
Interventions: COMBINATION_PRODUCT: Abilify MyCite - Digital Medicine System|DRUG: Aripiprazole or other oral antipsychotics
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Zebutinib Combined With Immunochemotherapy in the Treat of Newly Treated CLL Patients Without 17p-/TP53 Mutation
Status: NOT_YET_RECRUITING
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Zebutinib&BR or Zebutinib&FCR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk Factors, Prognosis, and Potential Chemoprevention Drugs in Patients With Recurrent Hepatocellular Carcinoma After Curative Surgeries: a Nationwide Retrospective Cohort Study and a Multi-center Prospective Cohort Analysis
Status: RECRUITING
Conditions: Hepatocellular Carcinoma Recurrent|Surgery
Interventions: OTHER: No intervention for research purpose
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transcranial Magnetic Stimulation (TMS) Treatment for Patients With Persistent Auditory Hallucinations
Status: COMPLETED
Conditions: Schizophrenia|Hallucinations
Interventions: DEVICE: repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DV in Combination With Pertuzumab With or Without Toripalimab Neoadjuvant Therapy With HER2-positive Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Disitamab Vedotin Injection|DRUG: Pertuzumab Injection|DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fludarabine, Cyclophosphamide, and Rituximab in Treating Patients Who Have Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: fludarabine phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Chemotherapeutic Treatments in Patients Aged 75 Years and Over Treated for Lymphoid Hematological Malignancy
Status: RECRUITING
Conditions: Neoplasm, Plasma Cell|Lymphoma
Interventions: PROCEDURE: Comprehensive Geriatric Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Safety of ATR-04
Status: SUSPENDED
Conditions: Epidermal Growth Factor|Papulopustular Rosacea
Interventions: DRUG: ATR-04|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Combined Role of Position Emission Tomography (PET) and Magnetoencephalography (MEG) in Nonlesional Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DEVICE: magnetoencephalography|DEVICE: Positron emission tomography (PET)|DEVICE: Magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: M-Tapa Block vs External Oblique Intercostal Block for Laparoscopic Cholesistectomy
Status: COMPLETED
Conditions: Cholecystitis|Cholecystitis, Acute
Interventions: DRUG: M-TAPA|DRUG: EOB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OLE Study for Patients With Parkinson's Disease With Dementia Enrolled in Study ANAVEX2-73-PDD-001
Status: COMPLETED
Conditions: Parkinson Disease Dementia
Interventions: DRUG: ANAVEX2-73
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Iressa in Patients With Chemo Refractory Germ Cell Tumors Expressing EGFR
Status: TERMINATED
Conditions: Refractory Germ Cell Tumors Expressing EGRF
Interventions: DRUG: ZD1839 Iressa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Losartan and HCTZ and Amlodipine vs Atenolol and Amlodipine (0954A-309)(COMPLETED)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: MK0954, losartan potassium/Duration of Treatment: 18 weeks|DRUG: Comparator: losartan, HCTZ, amlodipine, atenolol/Duration of Treatment: 18 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ayahuasca Assisted Psychotherapy for Grief
Status: ENROLLING_BY_INVITATION
Conditions: Bereavement
Interventions: DRUG: Ayahausca-Assisted psychotherapy|BEHAVIORAL: Constructivist Psychotherapy|OTHER: No treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Norfloxacin Therapy for Patients With Cirrhosis and Severe Liver Failure
Status: TERMINATED
Conditions: Cirrhosis
Interventions: DRUG: Norfloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Study Between Steroid Plus Anesthetic Block and CRF in Participants With Hip Osteoarthritis
Status: SUSPENDED
Conditions: Hip Osteoarthritis|Chronic Pain
Interventions: PROCEDURE: CRF of anterior sensitive branches to the hip|PROCEDURE: Anesthetic block with steroid injection of anterior sensitive branches to the hip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stroke and CPAP Outcome Study 3
Status: RECRUITING
Conditions: Ischemic Stroke|Intra Cerebral Hemorrhage|Obstructive Sleep Apnea|Adherence, Treatment|Motivation
Interventions: DEVICE: Continuous positive airway pressure (CPAP)|BEHAVIORAL: CPAP technical support intervention|BEHAVIORAL: Motivational Enhancement Therapy (MET)|BEHAVIORAL: Mobile Health intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-admission: A New Treatment Approach for Patients With Severe Eating Disorders
Status: COMPLETED
Conditions: Eating Disorders|Anorexia Nervosa|Bulimia Nervosa
Interventions: OTHER: Patient self-admission to inpatient treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blinded Randomized Placebo-Controlled Study Efficacy and Safety of Injectafer in ID Patients With Fibromyalgia
Status: COMPLETED
Conditions: Iron Deficiency|Fibromyalgia
Interventions: DRUG: Injectafer|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Saxagliptin in Triple Therapy to Treat Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Saxagliptin|DRUG: Dapagliflozin|DRUG: Metformin IR|DRUG: Placebo matching with Saxagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fludarabine Followed By Adoptive Immunotherapy in Treating Patients With Stage IV Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: therapeutic autologous lymphocytes|DRUG: fludarabine phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can the Memory Support Intervention Improve Depression Outcome Following Cognitive Therapy?
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: BEHAVIORAL: Cognitive Therapy (CT) for depression|BEHAVIORAL: Cognitive Therapy (CT) for depression + Memory Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Molecular Correlates of Positron Emission Tomography (PET) With 89Zr-DFO-huJ591 in Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: 89Zr-DFO-huJ591
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Pts With Philadelphia Chromosome-Pos ALL With Comb of Ibrutinib, Dasatinib, and Prednisone
Status: WITHDRAWN
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Ibrutinib|DRUG: Dasatinib|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylaxy of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgery
Status: UNKNOWN
Conditions: Postoperative Complications|Postoperative Nausea and Vomiting
Interventions: DRUG: Group A - gabapentin 600 mg|DRUG: Group B - pregabalin|DRUG: Group C - placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of Rozanolixizumab in Pediatric Study Participants With Moderate to Severe Generalized Myasthenia Gravis
Status: RECRUITING
Conditions: Generalized Myasthenia Gravis
Interventions: DRUG: rozanolixizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palonosetron and Dexamethasone With or Without Dronabinol in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy For Cancer
Status: COMPLETED
Conditions: Chemotherapy-induced Nausea and Vomiting|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: dexamethasone|DRUG: dronabinol|DRUG: palonosetron hydrochloride|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Buccal Prochlorperazine Versus Intravenous Prochlorperazine for Migraine Headaches, a RCT
Status: UNKNOWN
Conditions: Migraine Disorders
Interventions: DRUG: Prochlorperazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer
Interventions: BIOLOGICAL: bevacizumab|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT