pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Prospective Two-Year Study to Assess Miconazole Nitrate Resistance in Neonates and Infants
Status: COMPLETED
Conditions: Diaper Rash
Interventions: DRUG: 0.25 % Miconazole Nitrate Ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eat, Move, Live Intervention in Reducing Chronic Disease Risk in Medically Vulnerable Communities
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Subject
Interventions: BEHAVIORAL: Behavioral Dietary Intervention|OTHER: Educational Intervention|BEHAVIORAL: Exercise Intervention|BEHAVIORAL: Exercise Intervention|OTHER: Laboratory Biomarker Analysis|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Is Hyaluronic Acid Gel Effective on Oral Mucositis in Children Who Receiving Chemotherapy
Status: COMPLETED
Conditions: Oral Mucositis
Interventions: DRUG: Hyaluronic acid|DRUG: Sodium bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Norovirus GI.1/GII.4 Bivalent VLP Vaccine
Status: COMPLETED
Conditions: Healthy Volunteers|Norovirus, Prevention
Interventions: BIOLOGICAL: Hepatitis A Vaccine|BIOLOGICAL: Norovirus Bivalent VLP Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: IVB for Post-vitrectomy Hemorrhage in Diabetic Eyes
Status: COMPLETED
Conditions: Diabetic Retinopathy|Vitreous Hemorrhage
Interventions: DRUG: Bevacizumab Injection [Avastin]|PROCEDURE: Pars Plana Vitrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Shortened Regimens for Drug-susceptible Pulmonary Tuberculosis
Status: UNKNOWN
Conditions: Tuberculosis, Pulmonary
Interventions: DRUG: Isoniazid|DRUG: Rifampicin|DRUG: Pyrazinamide|DRUG: Ethambutol|DRUG: Levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative and Postoperative Imatinib Mesylate Study in Patients With c-Kit Positive GIST
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumors
Interventions: DRUG: Imatinib Mesylate (Gleevec)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zoledronic Acid (ZOMETA) With Cyclophosphamide With Neuroblastoma and Cortical Bone Involvement
Status: COMPLETED
Conditions: NEUROBLASTOMA
Interventions: DRUG: Zolendric acid|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short-Course Radiotherapy Followed by Neoadjuvant Chemotherapy, HLX07and Serplulimab in LARC
Status: ACTIVE_NOT_RECRUITING
Conditions: Rectal Cancer
Interventions: COMBINATION_PRODUCT: HLX07(anti EGFR antibody) and Serplulimab(anti PD-1 antibody)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Immunogenicity Equivalence of a Homologous Third Dose of Covid-19 (Recombinante) Vaccine
Status: UNKNOWN
Conditions: COVID-19
Interventions: BIOLOGICAL: Covid -19 (recombinante) vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of hAESCs Therapy for aGVHD
Status: NOT_YET_RECRUITING
Conditions: GVHD,Acute
Interventions: DRUG: Human Amniotic Epithelial Stem Cell Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acetaminophen/Codeine vs Acetaminophen/Ibuprofen for Pain Control and Patient Satisfaction After Hand Surgery
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Acetaminophen/Ibuprofen|DRUG: Acetaminophen/Codeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transarterial Radioembolisation in Comparison to Transarterial Chemoembolisation in Uveal Melanoma Liver Metastasis
Status: UNKNOWN
Conditions: Uveal Melanoma
Interventions: PROCEDURE: SIRT|PROCEDURE: DSM-TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Sanvar® With Endoscopic Treatment for the Control of Acute Variceal Bleeding
Status: COMPLETED
Conditions: Esophageal Varices|Portal Hypertension|Gastric Varices|Esophageal Bleeding
Interventions: DRUG: Sanvar® (vapreotide)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Immediate Effect of DAFO on Gross Motor Function and Balance in Diplegic Cerebral Palsy
Status: NOT_YET_RECRUITING
Conditions: Diplegic Cerebral Palsy
Interventions: OTHER: "Assessment of Balance and Lower Extremity Gross Motor Function with and without DAFO"
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mind Body Therapy During Geriatric Rehabilitation
Status: UNKNOWN
Conditions: Patients Who Are in Need of Short or Long Term Rehabilitation Due to Neurological Event (Mainly Stroke) or Post Orthopedic Surgery
Interventions: BEHAVIORAL: mind body therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of a Novel Probiotic Supplement on Menopausal Symptoms and Bone Health
Status: COMPLETED
Conditions: Menopause
Interventions: DIETARY_SUPPLEMENT: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Temsirolimus in Treating Patients With Locally Advanced or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Recurrent Breast Carcinoma|Stage III Breast Cancer AJCC v7|Stage IIIA Breast Cancer AJCC v7|Stage IIIB Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7|Stage IV Breast Cancer AJCC v6 and v7
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin to Augment Low Milk Supply (MALMS) Study
Status: COMPLETED
Conditions: Low Milk Supply|Pre-diabetes|Insulin Resistance|Suppressed Lactation
Interventions: BEHAVIORAL: Standard care|DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cervical Cerclage for Singleton Pregnant on Vaginal Progesterone With Progressive Cervical Length Shortening
Status: UNKNOWN
Conditions: Preterm Labor|Cervical Incompetence
Interventions: PROCEDURE: Cerclage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Umbilical Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With Hematologic Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Biphenotypic Leukemia|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Burkitt Lymphoma|Chronic Lymphocytic Leukemia|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Follicular Lymphoma|Lymphoblastic Lymphoma|Lymphoplasmacytic Lymphoma|Mantle Cell Lymphoma|Marginal Zone Lymphoma|Myelodysplastic Syndrome|Myelofibrosis|Non-Hodgkin Lymphoma|Plasma Cell Myeloma|Prolymphocytic Leukemia|Refractory Anemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Cyclosporine|PROCEDURE: Double-Unit Umbilical Cord Blood Transplantation|DRUG: Fludarabine|OTHER: Laboratory Biomarker Analysis|DRUG: Mycophenolate Mofetil|RADIATION: Total-Body Irradiation|PROCEDURE: Umbilical Cord Blood Transplantation|DRUG: Thiotepa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Helmet CPAP vs Facemask CPAP in ACPE (hCPAP vs fCPAP)
Status: COMPLETED
Conditions: Acute Cardiogenic Pulmonary Edema
Interventions: DEVICE: hCPAP vs fCPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel and Prednisone With/Out OGX-011 in Recurrent or Metastatic Prostate Cancer That Did Not Respond to Previous Hormone Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: custirsen sodium|DRUG: docetaxel|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for Low-Dose Opioid for TKA Replacement
Status: COMPLETED
Conditions: Knee Osteoarthritis|Pain, Postoperative|Acupuncture
Interventions: OTHER: Acupuncture|DEVICE: Peripheral Nerve Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ⅲ Study of HR19006 Injection in Postsurgical Parenteral Nutrition
Status: ACTIVE_NOT_RECRUITING
Conditions: Parenteral Nutrition
Interventions: DRUG: HR19006|DRUG: All-in-one parenteral nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Home Parenteral Nutrition (HPN) Families' Mobile Distance Connections to Care Research
Status: COMPLETED
Conditions: Short Bowel Syndrome|Malabsorption|Malnutrition
Interventions: BEHAVIORAL: HPN Group Clinic Appointments using Mobile Devices (experimental)|BEHAVIORAL: Mobile Device Access (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: To Explore the Functional Connectivity Pattern of Cortical Swallowing Network in the Oral Phase of Post-stroke Dysphagia Based on Dynamic Causal Modelling
Status: NOT_YET_RECRUITING
Conditions: Dysphagia After Stroke|Cortical Swallowing Network|Functional Magnetic Resonance Imaging|Oral Phase|Dynamic Causal Modelling
Interventions: DIAGNOSTIC_TEST: Swallowing function test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Allogeneic Microbiota-reconstitution (AMR) in Diarrhea-predominant Irritable Bowel Syndrome (IBS-D)
Status: UNKNOWN
Conditions: Diarrhea-predominant Irritable Bowel Syndrome
Interventions: PROCEDURE: Allogeneic microbiota reconstitution|PROCEDURE: Placebo-Allogeneic microbiota reconstitution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sophia Step Study - a Behaviour Change Program on Physical Activity in Persons With Pre- and Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes|Prediabetes
Interventions: BEHAVIORAL: Pedometer intervention|BEHAVIORAL: Group meetings|BEHAVIORAL: Individual consultations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxylated Polymethoxy Flavones Solid Dispersion in Treatment of Periodontitis
Status: NOT_YET_RECRUITING
Conditions: Inflammatory Disease|Periodontal Diseases
Interventions: PROCEDURE: scaling and root planing|DRUG: hydroxylated poly methoxy flavones|DRUG: chlorhexidine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO)
Status: UNKNOWN
Conditions: Patent Foramen Ovale
Interventions: DEVICE: Device closure|DRUG: Standard medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Probiotic Supplements on Metabolic Control of People With Type 2 Diabetes Mellitus in Greece
Status: ENROLLING_BY_INVITATION
Conditions: Diabetes Mellitus, Type 2
Interventions: DIETARY_SUPPLEMENT: LactoLevure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of High-flow Nasal Cannula Oxygen on Lung Volumes Determined by Electrical Impedance Tomography
Status: COMPLETED
Conditions: Critical Care|High-flow Nasal Cannula Oxygen|Electrical Impedance Tomography|End Expiratory Lung Volume|End Expiratory Lung Impedance|Diaphragmatic Ultrasound
Interventions: OTHER: High-flow nasal cannula oxygen
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy, Safety and Pharmacokinetics of BIRB 796 BS Tablets in Patients With Active Rheumatoid Arthritis
Status: TERMINATED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: BIRB 796 BS, low dose|DRUG: BIRB 796 BS, high dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Mirtazapine and Megestrol for the Control of Anorexia-cachexia in Cancer Patients in Palliative Care.
Status: COMPLETED
Conditions: Cachexia; Cancer|Anorexia
Interventions: DRUG: Mirtazapine|DRUG: Megestrol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial to Evaluate PROblem Solving Therapy and APPLE Watch for College Students
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use Disorder
Interventions: BEHAVIORAL: PST-APPLE Watch group|BEHAVIORAL: Education-only control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AMG 386 and Abiraterone for Advanced Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasms|Prostate Cancer|Neoplasm, Prostate|Neoplasm,Prostatic
Interventions: DRUG: AMG 386|DRUG: Abiraterone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Assessing Safety and Immunogenicity of IC43 Vaccination Against Pseudomonas Aeruginosa in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: IC43|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial of Gargling Agents in Reducing Intraoral Viral Load Among COVID-19 Patients
Status: UNKNOWN
Conditions: Covid-19
Interventions: DRUG: Gargle/Mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: VX-950-TiDP24-C136 - A Trial to Evaluate the Effect of Telaprevir (TVR) on the Results of Electrocardiograms (Electric Recording of the Heart) in Healthy Volunteers
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Telaprevir; Moxifloxacin; Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Exercises Performed According to Circadian Rhythm in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: OTHER: Morning Chronotype group|OTHER: Evening Chronotype group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Mediterranean Diet and Omega-3 Fatty Acids on Oxidative Stress and Endothelial Progenitor Cells (EPC's)
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Mediterranean Diet|DIETARY_SUPPLEMENT: Mediterranean Dietary Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial of Liposomal Versus Plain Bupivacaine in Minimally Invasive General Surgery Procedures
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: liposomal bupivicaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Open-label Safety, Tolerability and Dose-Range Finding Study of Multiple Doses of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy
Status: COMPLETED
Conditions: Spinal Muscular Atrophy
Interventions: DRUG: Nusinersen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety/Tolerability of Subcutaneous MK-3222 in Participants With Moderate-to-Severe Chronic Plaque Psoriasis (MK-3222-012)
Status: WITHDRAWN
Conditions: Plaque-type Psoriasis
Interventions: DRUG: MK-3222 200 mg|DRUG: MK-3222 100 mg|DRUG: Placebo to MK-3222|DRUG: Placebo to Etanercept|DRUG: Etanercept 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 52-week add-on to Metformin Comparison of Saxagliptin and Sulphonylurea, With a 52-week Extension Period
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Metformin|DRUG: Sulphonylurea|DRUG: Saxagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Auto Transplant High Dose Melphalan vs High Dose Melphalan+Bortezomib in Pts With Multiple Myeloma Age 65 Years or Older
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Melphalan|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ONDANSETRON AND EFFECTIVE DOSE IN 50% OF SUBJECTS OF PROPHYLACTIC NOREPINEPHRINE INFUSIONS FOR PREVENTING SPINAL ANESTHESIA-INDUCED HYPOTENSION DURING CESAREAN DELIVERY
Status: UNKNOWN
Conditions: Hypotension|Anesthesia; Adverse Effect, Spinal and Epidural|Cesarean Section
Interventions: DRUG: Ondansetron 4 MG|DRUG: 0.9% Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Commercially Available Carbohydrate Rich Gel on Maternal Fatigue: A Randomized Controlled Trial
Status: WITHDRAWN
Conditions: Effect of Carbohydrate Ingestion During Active Labor
Interventions: DIETARY_SUPPLEMENT: energy gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Role of Midodrine and Tolvaptan in Patients With Cirrhosis With Refractory or Recurrent Ascites
Status: COMPLETED
Conditions: Cirrhosis|Refractory/Recurrent Ascites
Interventions: DRUG: Standard medical therapy|DRUG: Tolvaptan|DRUG: Midodrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Rising Oral Doses of BI 207127 NA as Powder in the Bottle in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Placebo|DRUG: BI 207127 NA powder for solution|DRUG: BI 207127 NA tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery
Status: COMPLETED
Conditions: Major Depressive Disorder|Surgery|Orthopedic Disorder
Interventions: DRUG: Ketamine|DRUG: Normal saline (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carboplatin-Paclitaxel-Pembrolizumab in Neoadjuvant Treatment of Locally Advanced Cervical Cancer
Status: UNKNOWN
Conditions: Locally Advanced Cervical Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Carboplatin|DRUG: Taxol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Explorative Study of Degarelix for Treatment of Benign Prostatic Hyperplasia.
Status: COMPLETED
Conditions: BPH
Interventions: DRUG: Degarelix|DRUG: Degarelix|DRUG: Degarelix|DRUG: Degarelix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Carmustine, Streptozocin, and Mercaptopurine for Refractory or Recurrent Brain Neoplasms
Status: COMPLETED
Conditions: Anaplastic Astrocytoma|Anaplastic Oligodendroglioma|Mixed Gliomas|Glioblastoma Multiforme|Recurrent Brain Tumor
Interventions: DRUG: carmustine|DRUG: mercaptopurine|DRUG: streptozocin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Study of Quantitative Serial Trends in Lipids With ApolpoproteinA-I Stimulation
Status: COMPLETED
Conditions: Coronary Artery Disease|Dyslipidemia
Interventions: DRUG: RVX000222|DRUG: Placebo RVX000222
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Hospitalized Patients With Community-Acquired Pneumonia and Sepsis
Status: COMPLETED
Conditions: Pneumonia|Sepsis
Interventions: DRUG: Recombinant Chimeric Monoclonal Antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effectiveness of Cevimeline on Oral Health in Patients With Radiation Induced Xerostomia
Status: COMPLETED
Conditions: Xerostomia
Interventions: DRUG: Cevimeline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on the Safety and Effectiveness of NK Cells/Combined Monoclonal Antibodies in the Treatment of Hematological Malignancies
Status: NOT_YET_RECRUITING
Conditions: Hematological Malignancies
Interventions: DRUG: NK cells/Combined Monoclonal Antibodies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin C on Postoperative Pulmonary Complications After Intracranial Tumor Surgery
Status: NOT_YET_RECRUITING
Conditions: Ascorbic Acid|Neurosurgical Procedures|Humans|Ventilator-Induced Lung Injury|Postoperative Complications
Interventions: DRUG: Ascorbic acid|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Safety and Efficacy of MK0859 (Anacetrapib) in Japanese Patients With Dyslipidemia (0859-029)
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: anacetrapib|DRUG: Comparator: atorvastatin|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Kinetic of the Analgesic Effect and Tolerability of Eschscholtzia Californica Versus Ibuprofen and Placebo in the Treatment of Pain After Surgery of the Third Molar
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Eschscholtzia Californica - low dose|DRUG: Eschscholtzia Californica - high dose|DRUG: Ibuprofen|DRUG: Eschscholtzia Californica - low dose Placebo|DRUG: Eschscholtzia Californica - high dose Placebo|DRUG: Ibuprofen Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Study to Compare the Lipid Effects of Niacin ER and Simvastatin (NS) to Atorvastatin in Subjects With Hyperlipidemia or Mixed Dyslipidemia (SUPREME)
Status: COMPLETED
Conditions: Hyperlipidemia|Mixed Dyslipidemia
Interventions: DRUG: Niacin ER/Simvastatin Tablets|DRUG: atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Two Digital Therapeutics for the Prevention of Episodic Migraine Receiving CGRP Therapy (ReMMiD-C)
Status: ACTIVE_NOT_RECRUITING
Conditions: Migraine|Episodic Migraine|Headache|Headache, Migraine
Interventions: DEVICE: Click Digital Therapeutic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Pravastatin on Cholesterol, Inflammation and Cognition in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorders|Schizophreniform Disorders
Interventions: DRUG: Pravastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Statins and Cerebral Blood Flow in Subarachnoid Hemorrhage (SAH)
Status: COMPLETED
Conditions: Subarachnoid Hemorrhage
Interventions: DRUG: Simvastatin, 80 mg/day for 21 days|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: New Biomarkers and Therapeutic Targets in Osteoporosis Via Omics Technologies
Status: RECRUITING
Conditions: Osteoporosis, Postmenopausal|Osteoporosis Fracture|Osteoporosis, Severe
Interventions: OTHER: Bone, Serum and Plasma sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 2 Study of Belzutifan (PT2977, MK-6482) for the Treatment of Von Hippel Lindau (VHL) Disease-Associated Renal Cell Carcinoma (RCC) (MK-6482-004)
Status: ACTIVE_NOT_RECRUITING
Conditions: VHL - Von Hippel-Lindau Syndrome|VHL Gene Mutation|VHL Syndrome|VHL Gene Inactivation|VHL-Associated Renal Cell Carcinoma|VHL-Associated Clear Cell Renal Cell Carcinoma
Interventions: DRUG: Belzutifan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Of Neoadjuvant Chemotherapy or Radiochemotherapy With Or Without SHR-1210 In Patients With Resectable ESCC.
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Resectable Esophageal Squamous Cell Carcinoma
Interventions: DRUG: SHR-1210
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations
Status: RECRUITING
Conditions: HIV|Contingency Management|Justice Involved Populations|Status Neutral Interventions
Interventions: BEHAVIORAL: Health Navigation|BEHAVIORAL: Health Navigation, Employment Navigation plus Contingency Management Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Periodical Presumptive Treatment for the Control of Gonococcal Infections Among Sex Workers
Status: COMPLETED
Conditions: Neisseria Gonorrhoeae Infection|Chlamydia Trachomatis|HIV
Interventions: DRUG: Monthly antibiotic|DRUG: Monthly placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotic Versus Placebo as Adjuvant for Bacterial Vaginosis Treatment During Pregnancy
Status: UNKNOWN
Conditions: Bacterial Vaginosis
Interventions: DRUG: Lactobacillus acidophilus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Norepinephrine and Phenylephrine Boluses for Postspinal Anesthesia Hypotension
Status: COMPLETED
Conditions: Adverse Effect
Interventions: DRUG: Phenylephrine|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Blood Flow Restriction Training Following Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Total Knee Arthroplasty|Osteoarthritis
Interventions: DEVICE: DelfiPTS tourniquet system|OTHER: Standard physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib, Pembrolizumab, and Paclitaxel for Treatment of Recurrent Endometrial, Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Platinum-Resistant Fallopian Tube Carcinoma|Platinum-Resistant Ovarian Carcinoma|Platinum-Resistant Primary Peritoneal Carcinoma|Recurrent Endometrial Carcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma
Interventions: DRUG: Lenvatinib|DRUG: Paclitaxel|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Collaboration Between Doctors and Patients to Improve Asthma
Status: COMPLETED
Conditions: Asthma|Lung Diseases
Interventions: BEHAVIORAL: Status Reports
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Parent Telehealth Intervention for Children With Autism
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Autism
Interventions: BEHAVIORAL: Responsive training with no video feedback|BEHAVIORAL: Responsive training with video feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Tissue in Regenerative Endodontic Procedures and Apexification
Status: WITHDRAWN
Conditions: Dental Pulp Regeneration
Interventions: DRUG: Experimental: Regeneration Treatment Group|PROCEDURE: Control Non-Study Drug Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Exogenous Sodium Lactate Infusion in Traumatic Brain Injury (ELI-TBI)
Status: WITHDRAWN
Conditions: Brain Injuries, Traumatic
Interventions: DRUG: Sodium Lactate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ixabepilone and Carboplatin +/- Bevacizumab in Advanced Non-Small-Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Ixabepilone|DRUG: Carboplatin|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RIC (Remote Ischemic Conditioning) in Older Individuals
Status: NOT_YET_RECRUITING
Conditions: Old Age|Mobility Limitation|Debility
Interventions: OTHER: Low-intensity resistance exercise training|OTHER: Remote ischemic conditioning (RIC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Age Related D-dimer Evaluation for the Exclusion of a Left Atrium Thrombus in Patients With Atrial Fibrillation (ADDIT-AF)
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Triamcinolone With Vitamin D Synergistic Efficacy in Psoriasis
Status: RECRUITING
Conditions: Plaque Psoriasis|Vitamin D3
Interventions: DRUG: Triamcinolone|DIETARY_SUPPLEMENT: Vitamin D3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Group and Individual Training in EFT for Patients in Remission From Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma (Skin)
Interventions: BEHAVIORAL: Emotional Freedom Techniques (EFT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Proximal Pole Scaphoid Reconstruction Using Proximal Hamate
Status: ACTIVE_NOT_RECRUITING
Conditions: Closed Fracture Scaphoid, Proximal Pole|A Proximal Pole of Scaphoid That is Deemed Unsalvageable
Interventions: PROCEDURE: Hemi-Hamate Transfer for Proximal Pole Scaphoid Reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Rifaximin in the Treatment of Tropical Enteropathy
Status: COMPLETED
Conditions: Tropical Enteropathy
Interventions: DRUG: Rifaximin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Staphylococcus and Neisseria Tablets on Clinical Outcome Among Patients With Chronic Obstructive Pulmonary Disease
Status: NOT_YET_RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Staphylococcus and Neisseria Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of the Seaweed Supplement Fucoidan in Survivors of Cancer
Status: NOT_YET_RECRUITING
Conditions: Fatigue|Inflammation
Interventions: DIETARY_SUPPLEMENT: Fucoidan extracted from F. Vesiculosus|DIETARY_SUPPLEMENT: Fucoidan extracted from U. Pinnatifida
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: [18F]-AraG for the Detection of T-Cell Activation in Advanced Non-small Cell Lung Cancer Patients Undergoing PD-1/PD-L1-Directed Therapy
Status: WITHDRAWN
Conditions: Advanced Lung Non-Small Cell Carcinoma|Metastatic Lung Non-Small Cell Carcinoma|Stage III Lung Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8|Stage IIIB Lung Cancer AJCC v8|Stage IIIC Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: DRUG: Fluorine F 18 Ara-G
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Effects of Treatment With Bioarginin C in Adult Subjects Belonging to the Post-Covid Day Hospital
Status: UNKNOWN
Conditions: Fatigue Syndrome, Chronic|Inflammation
Interventions: DIETARY_SUPPLEMENT: Bioarginina C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Thoracoscopic Morrow Surgery in the Treatment of Hypertrophic Obstructive Cardiomyopathy
Status: RECRUITING
Conditions: Cardiomyopathy, Hypertrophic Obstructive|Minimally Invasive Surgery
Interventions: PROCEDURE: thoracoscopic Morrow surgery|PROCEDURE: modified Morrow surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Demonstrate That Antibiotics Are Not Needed in Moderate Acute Exacerbations of COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Sultamicillin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ICITRU : Randomized Trial of Immunonutrition With L-citrulline in Patients Hospitalized in Intensive Care for Sepsis or Septic Shock
Status: RECRUITING
Conditions: Sepsis|Septic Shock
Interventions: DIETARY_SUPPLEMENT: Experimental treatment L-citrulline (Protéocit®)|OTHER: Placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Concentration-Volume Relationship in Infraclavicular Block
Status: COMPLETED
Conditions: Brachial Plexus Blockade
Interventions: DRUG: Bupivacaine 0.25%|DRUG: Prilocaine 1%|PROCEDURE: Infraclavicular Nerve Block|DRUG: Bupivacaine 0.167%|DRUG: Bupivacaine 0.125%|DRUG: Prilocaine 0.66%|DRUG: Prilocaine 0.5%|DEVICE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prolonged Overnight Fasting and/or Exercise on Fatigue and Other Patient Reported Outcomes in Women With Hormone Receptor Positive Advanced Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: HER2-positive Breast Cancer|Advanced Breast Cancer
Interventions: BEHAVIORAL: Prolonged Overnight Fasting|BEHAVIORAL: Moderate-Intensity Exercise|BEHAVIORAL: General Health Education Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Arm Exercise Versus Pharmacologic Stress Testing for Clinical Outcome
Status: TERMINATED
Conditions: Veterans Referred to the St. Louis VAMC Stress Tes
Interventions: PROCEDURE: Regadenoson myocardial perfusion imaging stress test|PROCEDURE: Arm exercise electrocardiographic stress test|PROCEDURE: Treadmill electrocardiographic stress test|PROCEDURE: Coronary artery calcium score and cardiac computed tomographic angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SJ4 Post Approval Study in Implantable Cardioverter-Defibrillator and Cardiac Resynchronization Therapy Defibrillator Patients
Status: COMPLETED
Conditions: Tachyarrhythmias|Sudden Cardiac Death|Heart Failure
Interventions: DEVICE: SJ4 connector and RV high voltage SJ4 lead
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sevoflurane Induced Emergence Agitation
Status: COMPLETED
Conditions: Emergence Agitation
Interventions: DRUG: midazolam|DRUG: alfentanil|DRUG: ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy in Treating Patients With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study for Vaginal Vault Prolapse After Hysterectomy: Comparison of Two Surgical Methods
Status: COMPLETED
Conditions: Vaginal Vault Prolapse
Interventions: PROCEDURE: vaginal surgery|PROCEDURE: laparoscopic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Test the Long Term Safety and Efficacy of the Beta-3 Agonist Mirabegron (YM178) in Patients With Symptoms of Overactive Bladder
Status: COMPLETED
Conditions: Urinary Bladder, Overactive
Interventions: DRUG: Mirabegron|DRUG: Tolterodine|DRUG: Placebo to Mirabegron|DRUG: Placebo to Tolterodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Summer Camp Study: Blood Glucose Control With a Bi-Hormonal Bionic Endocrine Pancreas
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: Bi-hormonal Bionic Pancreas|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-escalation Study of APG-1387 and Toripalimab in Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: APG-1387 for Injection|DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Clinical Trial of Guanfacine Extended Release for the Reduction of Aggression and Self-injuries Behavior Associated With Prader-Willi Syndrome
Status: WITHDRAWN
Conditions: Prader-Willi Syndrome
Interventions: OTHER: Placebo|DRUG: Guanfacine extended release (GXR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Study of Sinonasal and Skull-base Tumours Management
Status: RECRUITING
Conditions: Nasal Neoplasm|Nasal Neoplasm Benign|Skull Base Neoplasms|Skull Base Osteomyelitis|Sinonasal Disorder|Sinus Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Implantable Cardiac Monitors in High-Risk Post-Infarction Patients With Cardiac Autonomic Dysfunction
Status: COMPLETED
Conditions: Myocardial Infarction|Autonomic Nervous System Diseases
Interventions: DEVICE: Medtronic Reveal LINQ implantable cardiac monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sunscreen and After-sun-lotion Protection in Polymorphic Light Eruption
Status: COMPLETED
Conditions: Polymorphic Light Eruption
Interventions: OTHER: After-sun-lotion with DNA repair enzymes|OTHER: SPF30 sunscreen|OTHER: Placebo after-sun-lotion|OTHER: Intervention: none (only UV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Preoperative FOLFOX Versus Postoperative Risk-adapted Chemotherapy in Patients With Locally Advanced Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer
Interventions: DRUG: mFOLFOX (neoadjuvant)|DRUG: XELOX (neoadjuvant)|DRUG: mFOLFOX (adjuvant)|DRUG: XELOX (adjuvant)|DRUG: Capecitabine (adjuvant)|DRUG: infusional 5-FU/FA "AIO" regimen (adjuvant)|DRUG: infusional 5-FU/FA "de Gramont" (adjuvant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Artery DenervatIon Using Radial accesS in Uncontrolled HyperTensioN
Status: RECRUITING
Conditions: Hypertension
Interventions: PROCEDURE: Transfemoral Renal Denervation|PROCEDURE: Transradial Renal Denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Randomized Controlled Study of Photoelectric Detection in Cervical Cancer Screening
Status: NOT_YET_RECRUITING
Conditions: Uterine Cervical Cancer|Cervical Intraepithelial Neoplasia|High Grade Squamous Intraepithelial Lesions|Low Grade Squamous Intraepithelial Lesions
Interventions: DIAGNOSTIC_TEST: Detection of Cervical Lesions by Fluorescence Photoelectric Image
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: FFA-Induced Hypertension and Endothelial Dysfunction
Status: COMPLETED
Conditions: Endothelial Dysfunction|Hypertension
Interventions: DRUG: Intralipid 20% @ 20cc/hour|DRUG: Intralipid 20%@ 40cc/hour|DRUG: Normal Saline|DIETARY_SUPPLEMENT: 32-gram oral fat load|DIETARY_SUPPLEMENT: 64-gram oral fat load
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Restorative Eye Treatment and INhance in Upper Eyelid Blepharoplasty Surgery
Status: COMPLETED
Conditions: Eyelid Dermatochalasis|Dermatochalasis
Interventions: OTHER: Restorative Eye Treatment (RET) cream|OTHER: INhance with Trihex Technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety Study of Pembrolizumab (MK-3475) Versus Paclitaxel in Asian Participants With Advanced Gastric or Gastroesophageal Junction Adenocarcinoma Who Progressed After First-line Therapy With Platinum and Fluoropyrimidine (MK-3475-063/KEYNOTE-063)
Status: TERMINATED
Conditions: Gastric Neoplasms|Gastroesophageal Junction Adenocarcinoma
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Quality Improvement Initiative to Increase Breast Milk Use in a Chinese NICU: a Pilot Study
Status: COMPLETED
Conditions: Infant, Extremely Premature
Interventions: OTHER: breast milk consume promotion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE