pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Plasticity Biomarkers,Interleukin-6 and Motor Performance in Response to Vagus Nerve Stimulation After Stroke
Status: RECRUITING
Conditions: Stroke|Motor Disorders
Interventions: DEVICE: True Transcutaneous auricular Vagus Nerve Stimulation (TaVNS)|DEVICE: Sham Trancutaneous auricular Vagus Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy and Safety With CAR-T Immunotherapy for CD19 Positive Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: BIOLOGICAL: The Chimeric Antigen Receptor T Cell Immunotherapy (CAR-T)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plaque Removal Efficacy of Electric Toothbrushes in ADHD
Status: COMPLETED
Conditions: Attention Deficit and Hyperactivity Disorder|Dental Plaque
Interventions: DEVICE: Plaque removal efficacy of children's electric toothbrush (Oral-B D100 Vitality; Procter & Gamble, Cincinnati, OH, United States)|DEVICE: Plaque removal efficacy of children's soft manual toothbrush (Oral-B Stages 6-12 years; Procter & Gamble, Cincinnati, OH, United States)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Antidepressant Treatment for Premenstrual Syndrome and Premenstrual Dysphoric Disorder
Status: COMPLETED
Conditions: Premenstrual Syndrome
Interventions: DRUG: Sertraline|OTHER: Treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Efficacy Evaluation of BLI-801 as a Laxative in Constipated Adults
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: BLI-801|DRUG: BLI-801|DRUG: BLI-801|DRUG: BLI-801
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Using Transcranial Electrostimulation (TESA-HB) Therapy for the Treatment of Depressive Symptoms
Status: TERMINATED
Conditions: Mild to Moderate Depression
Interventions: DEVICE: TESA-HB Transcranial Electronic Stimulation Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation and Expansion Study of TAC-001 in Patients With Select Advanced or Metastatic Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced or Metastatic Solid Tumors
Interventions: DRUG: TAC-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LYS228 PK, Clinical Response, Safety and Tolerability in Patients With Complicated Intra-abdominal Infection (cIAI)
Status: TERMINATED
Conditions: Intra-abdominal Infections
Interventions: DRUG: LYS228|DRUG: Standard of care therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy Study of FK-506 and Cyclosporine in Vernal Keratoconjunctivits (VKC)
Status: COMPLETED
Conditions: Keratoconjunctivitis, Vernal
Interventions: DRUG: tacrolimus|DRUG: cyclosporins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: HepHospital: A Hepatology Home Hospital Intervention for Patients With Advanced Liver Disease
Status: NOT_YET_RECRUITING
Conditions: Cirrhosis|End Stage Liver DIsease|Liver Cirrhosis|Liver Disease Chronic
Interventions: BEHAVIORAL: Hepatology Home Hospital
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Assessment of the Efficacy and Safety of Alpelisib (BYL719) in Pediatric and Adult Patients With Megalencephaly-CApillary Malformation Polymicrogyria Syndrome (MCAP)
Status: RECRUITING
Conditions: Megalencephaly-capillary Malformation Polymicrogyria Syndrome (MCAP)
Interventions: DRUG: Alpelisib (BYL719)|DRUG: Matching placebo|PROCEDURE: Optional lumbar puncture + blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Kidneys Ability to Concentrate and Dilute Urine in Patients With Autosomal Dominant Polycystic Kidney Disease
Status: COMPLETED
Conditions: Polycystic Kidney, Autosomal Dominant|Chronic Kidney Diseases
Interventions: OTHER: Fluid intake|OTHER: Thirsting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Recent Onset Low Back Pain With Periradicular Injections of Meloxicam
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: saline|DRUG: Meloxicam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Valsartan Versus Amlodipine in Postmenopausal Women With Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Valsartan 320 mg|DRUG: Amlodipine 10 mg|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Venglustat in Patients With Renal Impairment
Status: COMPLETED
Conditions: Healthy Volunteers|Polycystic Kidney, Autosomal Dominant
Interventions: DRUG: Venglustat GZ/SAR402671
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Therapy for Cholangiocarcinoma
Status: RECRUITING
Conditions: Cholangiocarcinoma Non-resectable
Interventions: DRUG: Hematoporphyrin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Candesartan on Brain Natriuretic Peptide Levels in Subjects With Chronic Heart Failure
Status: TERMINATED
Conditions: Heart Failure
Interventions: DRUG: Candesartan and standard chronic heart disease therapy|DRUG: Standard chronic heart disease therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-range Finding Study of BF2.649 Effect on Patients With Obstructive Sleep Apnea (OSA)
Status: COMPLETED
Conditions: Obstructive Sleep Apnoea|Excessive Daytime Sleepiness
Interventions: DRUG: BF2.649|DRUG: BF2.649|DRUG: BF2.649|DRUG: BF2.649|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radiofrquency Ablation Combined With Cytokine-induced Killer Cells for the Patients With Cholangiocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Cholangiocarcinoma
Interventions: PROCEDURE: Radiofrequency ablation|BIOLOGICAL: Cytokine-induced killer cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pain, Discomfort, and Functional Impairments During Rapid and Slow Maxillary Expansion
Status: COMPLETED
Conditions: Maxillary Constriction
Interventions: DEVICE: Modified Hyrax Palatal Expander|DEVICE: Removable Palatal Expander
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Lidocaine Versus Placebo in Palliative Care Patients With Opioid-refractory Cancer Pain With Neuropathic Component: a Multicenter, Prospective, Double-blind Randomized Placebo-controlled Study.
Status: UNKNOWN
Conditions: Cancer|Pain With Neuropathic Component
Interventions: DRUG: Lidocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Long-Term Safety of MEDI-545 in Adult Participants With Systemic Lupus Erythematosus or Myositis
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Sifalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SensoGrip - a Pressuresensitive Writing System
Status: COMPLETED
Conditions: Developmental Delay in Fine Motor Function (Disorder)
Interventions: DEVICE: Usage of the SensoGrip-System comprised of the SensoGrip pen and a tablet app.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Understanding Mechanisms of Health Behavior Change
Status: COMPLETED
Conditions: Overweight and Obesity|Diet Modification|Incentives
Interventions: BEHAVIORAL: self-monitoring|BEHAVIORAL: daily monetary incentives|BEHAVIORAL: delayed lump sum monetary incentives
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pilot Study Evaluating the Safety of Electroducer Sleeve Medical Device for Temporary Cardiac Stimulation During Percutaneous Cardiovascular Interventions, in All Kind of Patients
Status: COMPLETED
Conditions: Coronary Disease|Valve Heart Disease|Pacemaker DDD
Interventions: DEVICE: Electroducer Sleeve
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of NEOVIST 370 INJ.(Iopromide 768.86mg) With Ultravist 370 INJ.(Iopromide 768.86mg) in Abdominal CT
Status: COMPLETED
Conditions: Abdominal CT
Interventions: DRUG: NEOVIST 370 INJ.(Iopromide 768.86mg)|DRUG: Ultravist 370 INJ.(Iopromide 768.86mg)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Low Dose Atropine Eye Drops in Myopic Egyptian Children
Status: NOT_YET_RECRUITING
Conditions: Myopia Progression|Axial Length, Eye|Sclera Thickness
Interventions: DRUG: low dose atropine eye drops|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Tocilizumab for Sever COVID-19 Infection in Breast Cancer vs. Non Cancer Pateints
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Tocilizumab|DRUG: traditional Covid -19 therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Fecal Microbiota Transplantation on Weight in Obese Patients With Non-alcoholic Fatty Liver Disease
Status: UNKNOWN
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: DIETARY_SUPPLEMENT: Diet|OTHER: FMT|OTHER: Physical Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 5-HTR2A, DRD2,and COMT Genes Polymorphisms and Olanzapine Plasma Concentration in Treatment of Early-onset Schizophrenia
Status: COMPLETED
Conditions: Early-onset Schizophrenia
Interventions: DRUG: olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Traditional Chinese Medicine as Preventive Method for Osteoporosis Induced by Adjuvant Endocrine Therapy
Status: COMPLETED
Conditions: Breast Cancer|Osteoporosis
Interventions: DRUG: Letrozole|DRUG: Zhongyaofufang|DRUG: Xianlinggubao
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nicotine Pharmacokinetic in Blood and Analysis of Exhaled Breath After E-cigarette Smoking.
Status: UNKNOWN
Conditions: Electronic Cigarette
Interventions: OTHER: administration of the liquid 1 and then the liquid 2|OTHER: administration of the liquid 2 and then the liquid 1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Post-SARS-CoV-2 Vaccinal Response in Immunocompromised Patients
Status: WITHDRAWN
Conditions: HIV Seropositivity|Immunodeficiency|Vaccination Reaction|Covid19
Interventions: DIAGNOSTIC_TEST: Blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effect of Intravenous Acetaminophen on Postoperative Opioid-related Complications
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Intravenous Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma Receiving Oral ABBV-453 Tablets
Status: RECRUITING
Conditions: Relapsed/Refractory Multiple Myeloma
Interventions: DRUG: ABBV-453|DRUG: Dexamethasone|DRUG: Daratumumab|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Safety, Tolerability and Immune Response of Fimaporfin-induced Photochemical Internalisation of Antigen/Adjuvant
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Fimaporfin (Photosensitizer)|BIOLOGICAL: Hiltonol (Poly-ICLC)|BIOLOGICAL: HPV E7 (Human Papilloma Virus E7) peptides|BIOLOGICAL: KLH (Keyhole Limpet Hemocyanin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-transplantation Cyclophosphamide in Haploidentical Stem Cell Allografts Dose Reduction: 50 mg/kg vs 25 mg/kg
Status: ENROLLING_BY_INVITATION
Conditions: Graft Vs Host Disease
Interventions: DRUG: Cyclophosphamide|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Severe Alcohol-use Disorder: a tDCS and Response Inhibition Training Intervention
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: BEHAVIORAL: Combined TDCS active and ICT active|BEHAVIORAL: Combined TDCS sham and ICT active|BEHAVIORAL: Combined TDCS active and ICT inactive|BEHAVIORAL: Combined Sham TDCS and inactive ICT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effect of Pertuzumab in Patients With Advanced Non-Small Cell Lung Cancer, Which Has Progressed After Prior Chemotherapy
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Pertuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Hydrochloride, and Radiation Therapy in Patients With Borderline Resectable Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Adenocarcinoma|Stage IIA Pancreatic Cancer|Stage IIB Pancreatic Cancer|Stage III Pancreatic Cancer
Interventions: DRUG: Fluorouracil|DRUG: Gemcitabine Hydrochloride|RADIATION: Intensity-Modulated Radiation Therapy|DRUG: Irinotecan Hydrochloride|DRUG: Leucovorin Calcium|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Single and Multiple Doses of Inhaled AeroLEF (Liposome-Encapsulated Fentanyl)in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: i.v. fentanyl|DRUG: 3 mL AeroLEF (500 µg/1 mL)|DRUG: 3 mL AeroLEF (500 µg/1 mL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of MK0457 in Patients With T315I Mutant CML and Ph+All (0457-008)
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: MK0457
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Docetaxel (ModraDoc/r) in Combination With Hormonal Treatment and Radiation Therapy in High-risk Prostate Cancer
Status: TERMINATED
Conditions: Prostatic Neoplasms
Interventions: DRUG: oral docetaxel (ModraDoc/r)|DRUG: androgen deprivation therapy|RADIATION: high-dose intensity-modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Application and Basic Study of Medicinal Fractions-based Herbal Combinations
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: Ixeris of sonchifolia Hance|DRUG: Panax notoginseng saponins|DRUG: Ixeris of sonchifolia Hance combined with Panax notoginseng saponins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Mobile Phones in Out of Hospital Cardiac Arrest to Increase Bystander CPR
Status: COMPLETED
Conditions: Out-of-Hospital Cardiac Arrest|Death, Sudden, Cardiac|Heart Diseases|Ventricular Fibrillation
Interventions: OTHER: MLS dispatch for bystander CPR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Feasibility and Accuracy of Nanosensor-based Cancer Diagnosis at the Point-of-care (Chedza)
Status: COMPLETED
Conditions: Breast Neoplasms|Lymphoma
Interventions: DIAGNOSTIC_TEST: Contrast Microhalography (CEM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: CRT Versus Surgery for Retroperitoneal or Paraaortic Lymph Node Recurrence of CRC
Status: RECRUITING
Conditions: Colorectal Cancer|Retroperitoneal Lymph Node Metastasis|Para-aortic Lymph Node Metastasis
Interventions: PROCEDURE: lymphadenectomy|RADIATION: chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Radiotherapy in Treating Spinal Metastases
Status: NOT_YET_RECRUITING
Conditions: Spinal Metastases
Interventions: RADIATION: Intraoperative radiotherapy (IORT)|RADIATION: Stereotactic body radiotherapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SKLB1028, Daunorubicin, and Cytarabine in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia (AML)
Status: RECRUITING
Conditions: Newly Diagnosed Acute Myeloid Leukemia (AML)
Interventions: DRUG: SKLB1028 Dose Escalation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Intact and Hydrolyzed Pea Protein on Food Intake, Glycemic Response and Subjective Appetite
Status: COMPLETED
Conditions: Diabetes Prevention|Obesity Prevention
Interventions: OTHER: Dietary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Two Regimens of Artemether-lumefantrine for the Treatment of Malaria in Pregnancy
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: 3-day artemether-lumefantrine|DRUG: 5-day artemether-lumefantrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Clinical Trial of PR001 in Infants With Type 2 Gaucher Disease (PROVIDE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Gaucher Disease, Type 2
Interventions: GENETIC: LY3884961|DRUG: Methylprednisolone|DRUG: Sirolimus|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sustained Acoustic Medicine for Chronic Low Back Pain Secondary to Herniated Nucleus Pulposus or Other Conditions
Status: COMPLETED
Conditions: Chronic Low Back Pain (CLBP)|Intervertebral Disc Displacement
Interventions: DEVICE: Sustained Acoustic Medicine (SAM)|DEVICE: Sham Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Exenatide Plus Metformin vs. Insulin Aspart Plus Metformin on Glycemic Control and Hypoglycemia in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: exenatide twice daily (BID)|DRUG: premixed insulin aspart twice daily (BID)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thoracic Epidural Versus General Anesthesia for Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Epidural Anesthesia|General Anesthesia
Interventions: DRUG: Thoracic epidural effect on heart rate in Laparoscopic Cholecystectomy (bupivacaine and lignocaine)|DRUG: general anesthesia effect on heart rate in Laparoscopic Cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Study of STYLAGE® XXL for Volume Deficiency in the Mid-Face
Status: ACTIVE_NOT_RECRUITING
Conditions: Volume Deficiency in the Mid-Face|Aging|Aesthetics
Interventions: DEVICE: STYLAGE® XXL|DEVICE: STYLAGE® XXL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Clipping Versus Extracorporeal Ligation in Complicated Appendicitis Upper Egypt Overview
Status: NOT_YET_RECRUITING
Conditions: Appendicitis
Interventions: PROCEDURE: Laparoscopic appendectomy using clipping.|PROCEDURE: Laparoscopic appendectomy using extracorporeal ligation to secure the base of the appendix.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Nebulized Dexmedetomidine on Post-dural Puncture Headache
Status: COMPLETED
Conditions: Post-Dural Puncture Headache
Interventions: DRUG: Nebulized Dexmedetomidine|PROCEDURE: Bilateral greater occipital nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Image Guided Mapping for Cardiac Pacing Intervention
Status: COMPLETED
Conditions: Heart Failure
Interventions: PROCEDURE: Image guided Cardiac Resynchronization Therapy (CRT) device lead placement.|PROCEDURE: optimizing myocardial lead placement for Cardiac Resynchronization Therapy (CRT) devices
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LYR-220 for Adult Subjects With Chronic Rhinosinusitis (BEACON Study)
Status: COMPLETED
Conditions: Chronic Sinusitis|Chronic Rhinosinusitis (Diagnosis)
Interventions: DRUG: LYR-220 Design 1|DRUG: LYR-220 Design 2|DRUG: Bilateral sham procedure control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sickle Cell Disease Treatment With Arginine Therapy (STArT) Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Sickle Cell Disease
Interventions: DRUG: Arginine Hydrochloride|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Iron Supplementation of Marginally Low Birth Weight Infants
Status: COMPLETED
Conditions: Anemia|Iron-Deficiency|Child Behavior Disorders|Cognitive Manifestations
Interventions: DRUG: Iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: LY3022855 With BRAF/MEK Inhibition in Patients With Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: LY3022855|DRUG: Vemurafenib|DRUG: Cobimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mental Health Disparities in Spanish Speaking Latina Breast Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Depression, Anxiety|Mindfulness|Sleep Disturbance
Interventions: BEHAVIORAL: Mindfulness|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fluorometholone as Ancillary Therapy for TT Surgery
Status: COMPLETED
Conditions: Trichiasis|Trachoma|Bilamellar Tarsal Rotation
Interventions: DRUG: Fluorometholone 0.1% ophthalmic solution|OTHER: Artificial tears (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Telerehabilitation And Chair-based Yoga In The Elderly
Status: COMPLETED
Conditions: Telerehabilitation|Chair-based Yoga|Elderly People
Interventions: OTHER: Telerehabilitation|OTHER: information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Direct Pulp Capping in Primary Molars
Status: COMPLETED
Conditions: Direct Pulp Capping
Interventions: OTHER: Mineral trioxide aggregate (MTA)|OTHER: Hard setting Calcium Hydroxide (Dycal)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: "Cross" Closure for Reconstructing the Perineal Wound of Abdominoperineal Resection
Status: UNKNOWN
Conditions: Rectal Cancer|Anal Canal Cancer
Interventions: PROCEDURE: Traditional Closure|PROCEDURE: "Cross" closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Exposure Therapy for Acrophobia
Status: COMPLETED
Conditions: Specific Phobia|Acrophobia|Fear of Heights|Anxiety Disorders
Interventions: BEHAVIORAL: Exposure Therapy (Virtual Reality)|OTHER: Information Session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acthar for Treatment of Proteinuria in Membranous Nephropathy Patients
Status: COMPLETED
Conditions: Proteinuria|Idiopathic Membranous Nephropathy
Interventions: DRUG: Repository Corticotropin Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of Sacubitril/Valsartan Film-coated Tablets Under Fasting Conditions
Status: NOT_YET_RECRUITING
Conditions: Bioequivalence Study
Interventions: DRUG: Sacubitril and Valsartan Tablets 49mg/51mg|DRUG: Entresto® (Sacubitril and Valsartan Tablets 49mg/51mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of People With Rheumatoid Arthritis Who Require Joint Surgery in the Hand
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: PROCEDURE: Silicone metacarpophalangeal joint arthroplasty|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Effectiveness of the Oculeve Intranasal Lacrimal Neurostimulator in Patients With Dry Eye
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DEVICE: Intranasal Tear Neurostimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Open Label Study in Adults to Test the Efficacy of Mitoquinone/Mitoquinol Mesylate to Prevent Severe Viral Illness
Status: COMPLETED
Conditions: Respiratory Viral Infection|Antiviral Treatment|COVID-19
Interventions: DRUG: Mitoquinone/mitoquinol mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Periarticular Injection Versus Peripheral Nerve Block in Total Hip Arthroplasty
Status: COMPLETED
Conditions: Hip Arthropathy
Interventions: PROCEDURE: Nerve Block|PROCEDURE: Periarticular Injection (PAI)|DRUG: Ropivacaine|DRUG: Dex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study on Nasogastric (NG) Tube in Patients With Upper Gastrointestinal Bleed
Status: COMPLETED
Conditions: Gastrointestinal Hemorrhage|Liver Cirrhosis
Interventions: PROCEDURE: nasogastric tube placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Gemcitabine and Carboplatin in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer That Responded to Previous Cisplatin or Carboplatin
Status: WITHDRAWN
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Peritoneal Cavity Cancer
Interventions: DRUG: carboplatin|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Smoking Cessation Treatment for Methadone Maintenance Patients
Status: COMPLETED
Conditions: Smoking Cessation|Substance-Related Disorders
Interventions: DRUG: Varenicline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BFRT MPFL and ACL Reconstruction Rehab
Status: COMPLETED
Conditions: Medial Patellar Femoral Ligament Reconstruction Rehabilitation|Anterior Cruciate Ligament Reconstruction Rehabilitation
Interventions: OTHER: Rehabilitation utilizing blood flow restrictive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of MK-8666 in Participants With Type 2 Diabetes Mellitus (MK-8666-003)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: MK-8666|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Technical Outcomes of the Talent Abdominal Aortic Aneurysm (AAA) Stent-Graft Versus Cook Zenith Stent-Graft
Status: UNKNOWN
Conditions: Abdominal Aortic Aneurysm
Interventions: PROCEDURE: Endovascular Repair of the abdominal aorta|DEVICE: Cook Zenith Stent-Graft|DEVICE: Talent Stent-Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Oxidative Stress and L-CBMN Cytome Assay in Obese After 3 Weeks VLCD
Status: COMPLETED
Conditions: Obesity|Weight Loss|DNA Damage
Interventions: DEVICE: Very low calorie diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 68Ga-FAPI-RGD PET/CT Imaging in the Lung Cancer Patients
Status: RECRUITING
Conditions: Lung Neoplasms
Interventions: DRUG: 68Ga-FAPI-RGD|DRUG: 18F-FDG|DRUG: 68Ga-FAPI|DRUG: 68Ga-RGD
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Withdrawal Study to Demonstrate the Maintenance Effect in the Treatment of Non-24-Hour Sleep-Wake Disorder
Status: COMPLETED
Conditions: Non-24-Hour Sleep-Wake Disorder
Interventions: DRUG: tasimelteon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TreatmENT of AnastomotiC LeakagE After COLON Cancer Resection
Status: NOT_YET_RECRUITING
Conditions: Treatment|Anastomotic Leakage|Resection|Colon Cancer
Interventions: OTHER: Development of a model for predicting 90-day mortality and to compare various treatment strategies for anastomotic leakage
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study in Subjects With Moderate Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis|Eczema, Atopic
Interventions: DRUG: ALX-101 Gel 1.5% and ALX-101 Gel Vehicle|DRUG: ALX-101 Gel 5% and ALX-101 Gel Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of PD 0348292 for Preventing Blood Clots in the Lungs or Deep Leg Veins of Patients After Knee Surgery
Status: COMPLETED
Conditions: Venous Thrombosis
Interventions: DRUG: PD 0348292|DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Study Design of the Diacerein in Patients With Covid-19
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Diacerein|DRUG: placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Review of Medical Records of Patients Who Have Been Treated With Lutetium at the Cross Cancer Institute Between January 2010 and April 30, 2014
Status: ACTIVE_NOT_RECRUITING
Conditions: Neuroendocrine Tumors, NET
Interventions: DRUG: Lu-177 DOTA-TATE
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lesinurad/Allopurinol 200/300 FDC Tablets Bioequivalence
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: lesinurad/allopurinol 200/300 FDC tablet|DRUG: lesinurad 200 mg|DRUG: allopurinol 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Effects of a Probiotic on Autonomic and Psychological Stress
Status: COMPLETED
Conditions: Stress, Psychological
Interventions: DIETARY_SUPPLEMENT: ProbioStick|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2/Phase 3 Study To Evaluate The Efficacy And Safety Of Ramatroban Along With The Standard Of Care In Subjects Hospitalized For COVID Pneumonia
Status: RECRUITING
Conditions: COVID-19 Pneumonia|COVID-19 Respiratory Infection
Interventions: DRUG: Ramatroban|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of Two Dietary Supplements Claiming Anti-aging Properties
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: Wheat Polar Lipid Complex Oil|DIETARY_SUPPLEMENT: Wheat Polar Lipid Complex Powder|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Four Deconstructive Meditative Practices on Well-being and Self-deconstruction
Status: ACTIVE_NOT_RECRUITING
Conditions: Mental Health Wellness
Interventions: BEHAVIORAL: Mindful breathing|BEHAVIORAL: Prostrations, according to Tibetan Buddhist tradition|BEHAVIORAL: The Koan Mu, according to Zen Buddhist tradition|BEHAVIORAL: The mirror exercise, according to Toltec tradition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Impact of Inhaled Furosemide and Perorally Administered Levodropropizine on Dyspnea in Patients With Respiratory Diseases
Status: RECRUITING
Conditions: Dyspnea
Interventions: DRUG: Furosemide 40 mg|DRUG: Levodropropizine|OTHER: Placebo - saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study of Brentuximab Vedotin Combined With Bendamustine in Patients With Hodgkin Lymphoma
Status: COMPLETED
Conditions: Hodgkin Disease
Interventions: DRUG: brentuximab vedotin|DRUG: bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers
Status: NOT_YET_RECRUITING
Conditions: Smoking|Tobacco Use|Cigarette Smoking|E-Cig Use
Interventions: OTHER: E-cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intra-operative Nasal Compression After Lateral Osteotomy to Minimize Post-operative Peri-orbital Ecchymosis and Edema
Status: COMPLETED
Conditions: Rhinoplasty|Ecchymosis
Interventions: PROCEDURE: Direct compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Investigating the Effects of Typhoid Vaccine on Sleep in Healthy Volunteers
Status: COMPLETED
Conditions: Typhoid Vaccine on Sleep
Interventions: BIOLOGICAL: Typhoid Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interventional Study of Implantation of hESC-derived RPE in Patients With RP Due to Monogenic Mutation
Status: ACTIVE_NOT_RECRUITING
Conditions: Retinitis Pigmentosa
Interventions: BIOLOGICAL: Human Embryonic Stem Cell Derived Retinal Pigment Epithelium (RPE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study for the Evaluation of the Safety and Effectiveness of Use of a Poly-L Lactic Acid Injectable Filler for the Aesthetic Treatment of Nasolabial Folds
Status: ACTIVE_NOT_RECRUITING
Conditions: Wrinkle
Interventions: DEVICE: Gana V®|DEVICE: Sculptra®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Compare Giving AVODART And FLOMAX Together Or In A Combination Capsule In The Fed And Fasted State
Status: COMPLETED
Conditions: Prostatic Hyperplasia
Interventions: DRUG: Treatment sequence A|DRUG: Treatment sequence B|DRUG: Treatment sequence C|DRUG: Treatment sequence D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of a Combined Regimen of Fluoxetine, Prednisolone and Ivermectin in the Treatment of Mild COVID-19 to Prevent Disease Progression Progression in Papua New Guinea
Status: WITHDRAWN
Conditions: SARS-CoV2 Infection|COVID-19
Interventions: DRUG: Combination regimen: Fluoxetine, Prednisolone, Ivermectin|DRUG: Combination regimen: Albendazole, Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study With FE 999169 Versus Niflec for Colon Cleansing
Status: COMPLETED
Conditions: Colon Cleansing in Preparation for Colonoscopy
Interventions: DRUG: FE 999169|DRUG: Niflec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CSD200902: Assessment of Indoor Air Quality for a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in an Environmental Testing Chamber
Status: COMPLETED
Conditions: Tobacco Use|Smoking|Tobacco Smoking
Interventions: OTHER: Marlboro Gold Box|OTHER: Newport Box|OTHER: Non-combusted cigarette variant 42001401|OTHER: Non-combusted cigarette variant 42001399|OTHER: Non-combusted cigarette variant 40007386|OTHER: Non-combusted cigarette variant 42001402
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia and Diffuse Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: DRUG: asparaginase|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: prednisone|DRUG: vincristine sulfate|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Can we Use Intravenous Injection of Tranexamic Acid in Routine Practice With Active Management of the Third Stage of Labor?
Status: COMPLETED
Conditions: Obstetrical Hemorrhage
Interventions: DRUG: transamin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: INterest of the Negative Predictive Value of Integrons in Choosing a Narrow-spectrum Empirical anTibiotic Treatment vs Usual Empirical Antibiotic Treatment for Urinary Tract infectionS in the PEDiatric Emergency Department
Status: RECRUITING
Conditions: Urinary Tract Infections in Children
Interventions: PROCEDURE: integron research|PROCEDURE: usual practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety of Pentoxifylline and Vitamin E With Stereotactic Ablative Radiotherapy (SABR) in Non-small Cell Lung Cancers
Status: RECRUITING
Conditions: Non-small Cell Lung Cancers
Interventions: RADIATION: stereotactic ablative radiotherapy (SABR)|DRUG: Pentoxifylline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-emptive Infiltration of the Scalp With Diprospan Plus Ropivacaine for Pain After Craniotomy in Children
Status: RECRUITING
Conditions: Pain|Postoperative Children
Interventions: DRUG: The diprospan plus ropivacaine group|DRUG: The ropivacaine group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hemodynamic Responses to RLX030 Infusion in Subjects With Acute Heart Failure
Status: COMPLETED
Conditions: Acute Heart Failure
Interventions: DRUG: RLX030|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Childcare Resource on Cervical Cancer Prevention
Status: RECRUITING
Conditions: Cervical Dysplasia
Interventions: BEHAVIORAL: Navigation and EMR referral to childcare facility
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Ph I Zactima + Imatinib Mesylate & Hydroxyurea for Pts w Recurrent Malignant Glioma
Status: COMPLETED
Conditions: Glioblastoma|Gliosarcoma
Interventions: DRUG: Zactima, Gleevec, Hydroxyurea
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Follow-up Study for Subjects With Agitation Associated With Dementia of the Alzheimer's Type Who Previously Participated in a Double-blind Trial of Brexpiprazole or Placebo
Status: COMPLETED
Conditions: Agitation Associated With Alzheimer's Disease|Alzheimer's Type|Mental Disorder|Nervous System Diseases
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: De Novo Autoimmune Hepatitis in Pediatric Liver Transplantation
Status: TERMINATED
Conditions: De Novo Autoimmune Hepatitis
Interventions: OTHER: Pediatric transplant subject with d-AIH|OTHER: Pediatric transplant subject with acute rejection|OTHER: Pediatric transplant subject with chronic rejection|OTHER: Adult non-transplant patients with auto-immune hepatitis|OTHER: Adult non-transplant subjects with chronic hepatitis C virus|OTHER: Pediatric control subjects|OTHER: Adult transplanted subjects with de novo autoimmune hepatitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) for Patients With Rising Prostate-Specific Antigen (PSA)
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: GM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Xenon MRI Pulm Hypertension
Status: RECRUITING
Conditions: Pulmonary Hypertension|Pulmonary Arterial Hypertension
Interventions: DRUG: 129Xe Hyperpolarized
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC