pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Mindfulness-Based Reduction Stress Program
Status: COMPLETED
Conditions: Cancer|Caregiver Stress|Quality of Life
Interventions: BEHAVIORAL: Mindfulness Based Stress Reduction Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nitrate's Effect on Activity Tolerance in Heart Failure With Preserved Ejection Fraction
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Isosorbide Mononitrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: LivRelief Varicose Veins Cream in the Treatment of Varicose Veins
Status: COMPLETED
Conditions: Varicose Veins
Interventions: OTHER: Natural Health Product: LivRelief Varicose Veins Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Ranger™ Paclitaxel-Coated PTA Balloon Catheter and Uncoated PTA Balloons in Femoropopliteal Arteries
Status: COMPLETED
Conditions: Peripheral Artery Disease|Claudication|Atherosclerosis|Arteriosclerosis
Interventions: DEVICE: Ranger DCB|DEVICE: uncoated PTA balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Insulin RinGlar® Compared to Lantus® SoloStar® in Type 1 Diabetes Mellitus Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Diabetes Mellitus
Interventions: DRUG: Lantus Solostar, 100 Units/mL Subcutaneous Solution|DRUG: Insulin RinGlar, 100 Units/mL Subcutaneous Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment Facilities
Status: WITHDRAWN
Conditions: Crimean-Congo Hemorrhagic Fever|Lassa Fever
Interventions: DRUG: Ribavirin (Virazole) Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Metabolic Impact of Intermittent Carbohydrate Restriction in Individuals With Type 2 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Overweight and Obesity|Non-Alcoholic Fatty Liver Disease|Metabolic Syndrome
Interventions: OTHER: Dietary macronutrient composition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dose-finding and Safety Study of SHR4640 in Subjects With Hyperuricemia
Status: COMPLETED
Conditions: Hyperuricemia
Interventions: DRUG: Placebo|DRUG: SHR4640|DRUG: benzbromarone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of PBF-509 and PDR001 in Patients With Advanced Non-small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: DRUG: PBF-509_80 mg|DRUG: PBF-509_160 mg|DRUG: PBF-509_320 mg|DRUG: PBF-509_640 mg|DRUG: Combo PBF-509 (160 mg) + PDR001|DRUG: Combo PBF-509 (320 mg) + PDR001|DRUG: Combo PBF-509 (640 mg) + PDR001|DRUG: RP2D (PBF-509+PDR001)_immuno naïve|DRUG: Experimental: RP2D (PBF-509+PDR001)_immuno treated
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Efficacy of Methylphenidate Transdermal System (MTS) in Adolescents Aged 13-17 Years With ADHD
Status: COMPLETED
Conditions: ADHD
Interventions: DRUG: Methylphenidate Transdermal System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Senl-h19 CAR-T Cell Injection in the Treatment of Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia
Status: UNKNOWN
Conditions: B-ALL
Interventions: BIOLOGICAL: Senl-h19 CAR-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mhealth Application for anTicoagulation Care in Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation|Anticoagulants; Circulating, Hemorrhagic Disorder
Interventions: BEHAVIORAL: MATCh AFib application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Accessible and Inclusive Artificial Intelligence Assisted Chronic Disease Self-Management Telehealth Platform
Status: RECRUITING
Conditions: Disability Physical|Chronic Condition|Chronic Conditions, Multiple
Interventions: BEHAVIORAL: Scheduled Coaching + Gamified Rewards|BEHAVIORAL: Scheduled Coaching Calls + Independent Rewards|BEHAVIORAL: No Scheduled Coaching Calls + Gamified Rewards|BEHAVIORAL: No Scheduled Coaching Calls + Independent rewards
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of Gadodiamide Injection in Myocardial Perfusion Magnetic Resonance Imaging
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: OTHER: Perfusion CMR for detection of coronary artery disease|OTHER: Perfusion cardiac magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Study of Fixation or Fusion of Calcaneal Fractures
Status: COMPLETED
Conditions: Fractures, Comminuted|Fracture Fixation, Internal
Interventions: PROCEDURE: Open reduction internal fixation|PROCEDURE: Fusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Quercetin in Prevention and Treatment of Oral Mucositis
Status: COMPLETED
Conditions: Chemotherapy Induced Oral Mucositis
Interventions: DRUG: oral quercetin capsules|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Utility of Pharmacogenomic Testing in Patients With Gastrointestinal Disorders
Status: COMPLETED
Conditions: Gastrointestinal Diseases
Interventions: GENETIC: Pharmacogenomics (PGx) genetic testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Frequency of Diagnostic Symptomatic Pulmonary Embolism's in Patients Hospitalized for Clinical Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Patients Hospitalized for a COPD Exacerbation
Interventions: OTHER: PEP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Open Label Dose Escalation Phase I Study to Investigate the Safety and Pharmacokinetics of T121E01F and T121E02F in Healthy Postmenopausal Women
Status: COMPLETED
Conditions: Healthy Postmenopausal Women
Interventions: DRUG: T121|DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of the Beetroot Juice in Portuguese Swimmers
Status: COMPLETED
Conditions: Ergogenics
Interventions: DIETARY_SUPPLEMENT: Beetroot Juice|COMBINATION_PRODUCT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers
Status: RECRUITING
Conditions: Gastric Cancer|Colorectal Cancer|Pancreatic Cancer|Sarcoma|Mesothelioma|Neuroendocrine Tumors|Squamous Cell Cancer|Merkel Cell Carcinoma|Mismatch Repair Deficiency|Microsatellite Instability
Interventions: BIOLOGICAL: Tumor Infiltrating Lymphocytes (TIL)|DRUG: Fludarabine + Cyclophosphamide combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Relative Bioavailability of an Oral Suspension of Abrocitinib and Effect of an Acid Reducing Agent on the Bioavailability of Abrocitinib and Assessing the Taste of Abrocitinib Oral Formulations.
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Abrocitinib tablet|DRUG: Abrocitinib Suspension F1|DRUG: Abrocitinib Suspension F2|DRUG: Abrocitinib Suspension F3|DRUG: Abrocitinib Suspension F4|DRUG: Abrocitinib Suspension F5|DRUG: Abrocitinib Suspension F6|DRUG: Famotidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Contextual Interference Improve Retention of Basic Life Support Skills? A Randomized Controlled Trial
Status: COMPLETED
Conditions: Basic Life Saving Skills|Cardiopulmonary Resuscitation|Skill Retention
Interventions: OTHER: Modified BLS course|OTHER: Standard BLS Course
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pemetrexed and Avelumab in Treating Patients With MTAP-Deficient Metastatic Urothelial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant|Infiltrating Bladder Urothelial Carcinoma With Glandular Differentiation|Infiltrating Bladder Urothelial Carcinoma With Squamous Differentiation|Infiltrating Bladder Urothelial Carcinoma, Micropapillary Variant|Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant|Metastatic Urothelial Carcinoma|MTAP Negative
Interventions: DRUG: Avelumab|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-Line Treatment for HIV-2
Status: COMPLETED
Conditions: HIV-2 Infection
Interventions: DRUG: Tenofovir + Emtricitabine or Lamivudine + Zidovudine|DRUG: Tenofovir + Emtricitabine or Lamivudine + Lopinavir/ritonavir|DRUG: Tenofovir + Emtricitabine or Lamivudine + Raltegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing Imaging And plasMa biOmarkers iN Describing Heart Failure With Preserved Ejection Fraction (DIAMONDHFpEF)
Status: COMPLETED
Conditions: Patients With Heart Failure and Preserved Ejection Fraction - HFpEF|Patients With Heart Failure With Reduced Ejection Fraction - HFrEF|Healthy Controls Group - Age and Sex-matched
Interventions: DIAGNOSTIC_TEST: MRI scan, Echo scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Combination Therapy Including Anti-PD-1 Immunotherapy in MSS Rectal Cancer With Resectable Distal Metastasis
Status: NOT_YET_RECRUITING
Conditions: Advanced Rectal Cancer|Liver Metastasis|Pulmonary Metastasis|Microsatellite Stable Colorectal Carcinoma
Interventions: COMBINATION_PRODUCT: a combination therapy including tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Abutment Type Following Oral Implants in Terms of the Surrounding Bone Height
Status: COMPLETED
Conditions: Missing Teeth
Interventions: OTHER: Molded abutment|OTHER: 3D printed abutment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glue Sealing for Patients With Low-Output ECFs
Status: UNKNOWN
Conditions: Low-output External Gastrointestinal Fistula
Interventions: PROCEDURE: Endoscopy exploration and glue application|DRUG: Anti-Bacterial Agents|DIETARY_SUPPLEMENT: Nutrition support|PROCEDURE: PRFG preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Encapsulated Cell Technology (ECT) Implant for Patients With Late Stage Retinitis Pigmentosa
Status: COMPLETED
Conditions: Retinitis Pigmentosa
Interventions: COMBINATION_PRODUCT: Low Dose NT-501|COMBINATION_PRODUCT: High Dose NT-501
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Neuromodulation and Therapeutic Exercise in Patients With Nonspecific Chronic Neck Pain
Status: RECRUITING
Conditions: Neck Pain|Chronic Pain
Interventions: OTHER: Percutaneous neuromodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma.
Status: RECRUITING
Conditions: Relapsed/Refractory Follicular Lymphoma|Follicular Lymphoma|Refractory Follicular Lymphoma
Interventions: DRUG: Tazemetostat|DRUG: Tazemetostat|DRUG: Placebo oral tablet|COMBINATION_PRODUCT: Lenalidomide|COMBINATION_PRODUCT: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Imatinib in Patients With Locally Advanced/Metastatic Melanoma With c-KIT Mutation/Amplification
Status: WITHDRAWN
Conditions: Stage IIIA Skin Melanoma|Stage IIIB Skin Melanoma|Stage IIIC Skin Melanoma|Stage IV Skin Melanoma
Interventions: DRUG: Imatinib Mesylate|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of MT-2990 in Women With Endometriosis
Status: COMPLETED
Conditions: Endometrial Related Pain
Interventions: DRUG: MT-2990|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cytoreductive Surgery(CRS) Plus Hyperthermic Intraperitoneal Chemotherapy(HIPEC) With Lobaplatin in Advanced and Recurrent Epithelial Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer|Ovary Neoplasm|Ovarian Neoplasms|Epithelial Ovarian Cancer|Ovarian Cancer, Epithelial|Hyperthermic Intraperitoneal Chemotherapy(HIPEC)
Interventions: DEVICE: HIPEC|DEVICE: CRS|DEVICE: IVCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of a Palato-Pharyngeal Implant System (PPIS) Obstructive Sleep Apnea Syndrome (OSAS)
Status: COMPLETED
Conditions: Snoring|Obstructive Sleep Apnea
Interventions: DEVICE: Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Human C1 Inhibitor for the Treatment of Early Antibody-Mediated Rejection in Renal Transplantation
Status: WITHDRAWN
Conditions: Graft Rejection|Kidney Transplantation
Interventions: PROCEDURE: plasmapheresis and IVIG|DRUG: recombinant C1 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sucralose and Lactisole Additions to OGTT in Humans
Status: COMPLETED
Conditions: Neat OGTT|OGTT With Added Sucralose|OGTT With Added Lactisole
Interventions: DIETARY_SUPPLEMENT: TAS1R2/3 agonist or antagoinst admixture to oral glucose tolerance test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Virtual Reality Glasses on Anxiety During Cystoscopy: A Randomised Controlled Trial
Status: RECRUITING
Conditions: Cystoscopy|Virtual Reality|Anxiety
Interventions: DEVICE: virtual reality group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Biological Treatment of Amyotrophic Lateral Sclerosis
Status: UNKNOWN
Conditions: Amyotrophic Lateral Sclerosis
Interventions: OTHER: Biological: Cell-based therapeutics|OTHER: Symptomatic treatment of ALS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postprocedural Contrast Mediated FFR Plus Intracoronary Infusion of Nitroglycerin in Multivessel Patients (PROMETEUS TRIAL)
Status: RECRUITING
Conditions: Coronary Disease
Interventions: DIAGNOSTIC_TEST: Fractional Flow Reserve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of a Pictorial Flashcard Regarding Self-care of Peripheral Intravenous Cannula (PIVC) on Its Indwelling Time and Related Complications Among Inpatients
Status: COMPLETED
Conditions: Inpatient Facililty Diagnoses
Interventions: BEHAVIORAL: Teaching subjects regarding self-care of PIVC with Pictorial Flashcard.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 2 Study of Isatuximab in Combination With Bortezomib, Cyclophosphamide and Dexamethasone Followed by Isatuximab and Lenalidomide Maintenance in Newly Diagnosed Patients With Multiple Myeloma and Severe Renal Impairment
Status: NOT_YET_RECRUITING
Conditions: Multiple Myeloma|Renal Impairment|Neoplasms, Plasma Cell|Neoplasms by Histologic Type|Neoplasms|Paraproteinemias|Blood Protein Disorders|Hematologic Diseases
Interventions: DRUG: Isatuximab|DRUG: Bortezomib|DRUG: Cyclophosphamide|DRUG: Dexamethasone|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inflammation, Stress & Social Behavior: Using Ecological Assessments & Model Systems to Enhance Relevance to Health Outcomes
Status: WITHDRAWN
Conditions: Hepatitis C
Interventions: DRUG: Interferon-alpha
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immunization With Different Doses of Plasmodium Falciparum Sporozoites Under Chloroquine Prophylaxis
Status: COMPLETED
Conditions: Plasmodium Falciparum Malaria
Interventions: DRUG: Chloroquine prophylaxis|BIOLOGICAL: Immunization|BIOLOGICAL: Plasmodium falciparum challenge|DRUG: Malarone treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: CHinese Acute Tissue-Based Imaging Selection for Lysis In Stroke -Tenecteplase II
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: Tenecteplase|DRUG: The best treatment selected by local doctors(Aspirin, Recombinant Tissue Plasminogen Activator, Urokinase, Thrombectomy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TLR8 Agonist VTX-2337 and Pegylated Liposomal Doxorubicin Hydrochloride or Paclitaxel in Treating Patients With Recurrent or Persistent Ovarian Epithelial, Fallopian Tube, or Peritoneal Cavity Cancer
Status: COMPLETED
Conditions: Malignant Ovarian Mixed Epithelial Tumor|Ovarian Brenner Tumor|Ovarian Clear Cell Cystadenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian Mucinous Cystadenocarcinoma|Ovarian Serous Cystadenocarcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Undifferentiated Ovarian Carcinoma
Interventions: DRUG: TLR8 Agonist VTX-2337|OTHER: Diagnostic Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Pegylated Liposomal Doxorubicin Hydrochloride|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expectations and Priorities of Elderly Patients for a First Medical Treatment for Cancer
Status: UNKNOWN
Conditions: Breast Cancer|Colorectal Cancer|Kidney Cancer|Lung Cancer|Prostate Cancer|Sarcoma|Ovarian Cancer|Lymphoma
Interventions: OTHER: Consultation, evaluation questionnaire|OTHER: Geriatric consultation, evaluation questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exploratory Study of DHA in Systemic Lupus Erythematosus Patients
Status: UNKNOWN
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Dihydroartemisinin tablet|DRUG: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fiji Integrated Therapy (FIT) - Triple Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji
Status: COMPLETED
Conditions: Lymphatic Filariases|Scabies|Impetigo|Soil Transmitted Helminths
Interventions: DRUG: 3 drug dose - IDA|DRUG: 3 drug dose - IDA with second dose of ivermectin|DRUG: 2 drug dose - DA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-Blind Placebo-Controlled Trial to Assess Overall User Experience of a Synbiotic Vaginal Suppository
Status: ACTIVE_NOT_RECRUITING
Conditions: Vaginal Personal Care
Interventions: OTHER: VH-01 vaginal suppository tablet|OTHER: Placebo vaginal suppository tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Integrating Depression Care in Acute Coronary Syndromes Care in China
Status: COMPLETED
Conditions: Acute Coronary Syndromes|Depression
Interventions: OTHER: Integrated care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Peripheral Effects of Exercise on Cardiovascular Health (STRRIDE I)
Status: COMPLETED
Conditions: Cardiovascular Diseases|Heart Diseases|Obesity|Hyperlipidemia|Insulin Resistance|Metabolic Syndrome X
Interventions: BEHAVIORAL: physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: mHealth Technology in the Treatment of Post-concussion Symptoms
Status: NOT_YET_RECRUITING
Conditions: Post Concussion Syndrome
Interventions: OTHER: MyHeadHealth online application|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Using Interventional Informatics to Address Social Determinants of Health During Clinical Care Visits to Promote Behavior Change and PREVENT Cardiovascular Disease
Status: COMPLETED
Conditions: Cardiovascular Diseases|Obesity
Interventions: BEHAVIORAL: PREVENT tool|BEHAVIORAL: Wait-list Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Wearable Devices for Secondary Prevention of Ischemic Stroke
Status: UNKNOWN
Conditions: Stroke, Ischemic|Atrial Fibrillation
Interventions: DEVICE: Wearable devices for identifying and measuring risk factors for ischemic stroke|OTHER: Standard of care monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Early Glasses on the Development of Amblyopia
Status: ACTIVE_NOT_RECRUITING
Conditions: Amblyopia|Refractive Errors
Interventions: OTHER: Orthoptic care with the prescription of glasses from age 12-18 months onwards|OTHER: Orthoptic care without the prescription of glasses from age 12-18 months onwards|OTHER: First measurement only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of VEL-101
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: VEL-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer
Status: COMPLETED
Conditions: Anal Cancer
Interventions: DRUG: fluorouracil|DRUG: mitomycin C|RADIATION: Intensity-modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Corticosteroids for Children With Febrile Urinary Tract Infections
Status: COMPLETED
Conditions: Acute Urinary Tract Infection|Urinary Tract Infection
Interventions: DRUG: Placebo|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Comparison Study of LY2140023 and Aripiprazole in Schizophrenia Patients
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: LY2140023|DRUG: Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Double-Blind, Comparative, Randomized Clinical Study of the Pharmacokinetics, Safety, and Immunogenicity of a Single Intravenous Infusion of BCD-178 or Perjeta® in Healthy Volunteers
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: BCD-178|DRUG: Perjeta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Topically Applied DS107 Cream in Mild to Moderate Atopic Dermatitis Patients (AD)
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: DS107|OTHER: Vehicle cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Giving Chemotherapy for a Shortened Amount of Time Before a Stem Cell Transplantation
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematologic Malignancies
Interventions: DRUG: Busulfan 3.2 mg/kg/day|DRUG: Fludarabine|DRUG: Melphalan|DRUG: Antithymocyte globulin (ATG)|DRUG: Busulfan 0.8 mg/kg|PROCEDURE: Allogeneic hematopoietic cell transplantation (Allo-HCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromodulation of Conscious Perception: Investigating Thalamic Roles Through Ultrasonic Stimulation
Status: ENROLLING_BY_INVITATION
Conditions: Thalamus
Interventions: DEVICE: LIFUP excitation|DEVICE: LIFUP inhibition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase I-II for Patients With Recurrent or Refractory Non-small Cell Lung Cancer (NSCLC)
Status: WITHDRAWN
Conditions: Lung Cancer
Interventions: DRUG: Bevacizumab|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Valsartan and Nebivolol/Valsartan in Hypertensive Patients With LVH
Status: COMPLETED
Conditions: Hypertension Complicated|Hypertrophy, Left Ventricular|Blood Pressure
Interventions: DRUG: Valsartan 80 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Prospective Randomized Controlled Study of Intravitreal Injection of Bevacizumab for Proliferative Diabetic Retinopathy
Status: COMPLETED
Conditions: Proliferative Diabetic Retinopathy|Diabetic Traction Retinal Detachment|Vitreous Hemorrhage
Interventions: DRUG: Bevacizumab|PROCEDURE: Vitrectomy|DEVICE: Sham injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Development and Effectiveness of Museum-Based Experiences for Individuals With Chronic Pain
Status: COMPLETED
Conditions: Chronic Pain
Interventions: BEHAVIORAL: Usual care/wait list|BEHAVIORAL: Art Rx|BEHAVIORAL: Artful Meditation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Strategy to Improve Antiplatelet Therapy Adherence After Coronary Stent Implantation
Status: COMPLETED
Conditions: Coronary Artery Stent Thrombosis|Multiple Drug Use|Patient Compliance
Interventions: BEHAVIORAL: patient education and daily SMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Transcranial Direct Current Stimulation (tDCS) for the Treatment of Major Depressive Disorder
Status: UNKNOWN
Conditions: Major Depressive Disorders
Interventions: DEVICE: Transcranial Direct Current Stimulation (tDCS)-active|DEVICE: Transcranial Direct Current Stimulation (tDCS)-sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study to Characterize Phenotyping Metrics of the "Basel" Cocktail After CYP Induction or Inhibition
Status: COMPLETED
Conditions: Metabolic Detoxication, Phase I
Interventions: DRUG: Basel cocktail+(Fluconazole, Ciprofloxacin, Paroxetine)|DRUG: "Basel" Cocktail|DRUG: Basel cocktail + Rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Benefits of Continuous Glucose Monitoring With GEM Lifestyle Modification for Adults With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: GEM lifestyle modification & continuous glucose monitoring|OTHER: Routine Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Approach in Subacromial Impingement Syndrome
Status: UNKNOWN
Conditions: Shoulder Impingement Syndrome|Virtual Reality|Rehabilitation|Subacromial Impingement Syndrome
Interventions: DEVICE: Game Based Virtual Reality Exercises|OTHER: Conventional Physiotherapy and Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reflux Disease After Gastric Bypass Versus Sleeve Gastrectomy in Morbid Obese Patients: an Italian Study
Status: NOT_YET_RECRUITING
Conditions: Gastroesophageal Reflux Disease|Obesity
Interventions: PROCEDURE: Roux-en-Y-Gastric bypass, Sleeve gastrectomy|PROCEDURE: SG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Low Dose Metronidazole to Decrease Postoperative Pain After Endometriosis Surgery
Status: RECRUITING
Conditions: Endometriosis|Endometriosis-related Pain
Interventions: DRUG: Metronidazole Oral|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: VIA Family 4 Year Follow-up of a Family-based Preventive Intervention
Status: COMPLETED
Conditions: Mental Disorder
Interventions: BEHAVIORAL: VIA Family|BEHAVIORAL: Treatment As Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of 14-day Concomitant Therapy for Refractory Helicobacter Pylori Infection
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: three kinds of antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest of FSL 2 in Recently Diagnosed Type 2 Diabetic Patients
Status: RECRUITING
Conditions: Endocrinology|Type 2 Diabetes
Interventions: DEVICE: Freestyle Libre 2|OTHER: Therapeutic education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Laparoscopic Robot-assisted Pelvic Exenteration for Pelvic Primary and Recurrent Cancers
Status: RECRUITING
Conditions: Locally Advanced Pelvic Cancer That Require Pelvic Exenteration
Interventions: PROCEDURE: robot-assisted total pelvic exenteration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension Study of ACTIQ Treatment for Children and Adolescents With Breakthrough Pain
Status: COMPLETED
Conditions: Pain|Cancer|Sickle Cell Anemia|Severe Burns
Interventions: DRUG: ACTIQ (Oral Transmucosal Fentanyl Citrate [OTFC])
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Assessing AR-1105 in Subjects With Macular Edema Due to Retinal Vein Occlusion (RVO)
Status: COMPLETED
Conditions: Macular Edema
Interventions: DRUG: AR-1105-CF1|DRUG: AR-1105-CF2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photobiomodulation and Sonophoresis Improving Jaw Mobility and Quality of Life Among Head and Neck Cancer Survivors
Status: UNKNOWN
Conditions: Head and Neck Cancer|Trismus
Interventions: COMBINATION_PRODUCT: Photobiomodulation therapy with mandibular exercises|COMBINATION_PRODUCT: Sonophoresis with mandibular exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erector Spina Plane Block for Multilevel Major Spinal Surgery
Status: COMPLETED
Conditions: Pain|Post Operative Pain
Interventions: PROCEDURE: Erector spinae plane block|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FolateScan in Autoimmune Disease
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Osteoarthritis|Multiple Sclerosis|Crohn's Disease|Systemic Lupus Erythematosus
Interventions: DRUG: FolateScan (Technetium Tc 99mEC20)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Hormonal Mechanisms of Sleep Restriction - Axis Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Sleep Restriction
Interventions: DRUG: Ketoconazole Pill|DRUG: Ganirelix|DRUG: Dexamethasone|DRUG: Dexamethasone Injection|DRUG: Cosyntropin Injectable Product|DRUG: Recombinant Human Luteinizing Hormone|DRUG: Hydrocortisone Injection|DRUG: Gonadorelin|DRUG: Corticorelin|DRUG: Placebo oral capsule|DRUG: Saline Solution|DRUG: Saline Solution for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Regional Block of the Nose for Hypotensive Anaesthesia in Septo-rhinoplasty
Status: UNKNOWN
Conditions: Hypotensive Anesthesia
Interventions: OTHER: General anesthesia with fentanyl boluses|PROCEDURE: Regional block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia
Status: SUSPENDED
Conditions: B Acute Lymphoblastic Leukemia
Interventions: DRUG: Allopurinol|DRUG: Cytarabine|DRUG: Daunorubicin Hydrochloride|DRUG: Vincristine Sulfate|DRUG: Dexamethasone|DRUG: Pegylated L-Asparaginase|DRUG: Methotrexate|PROCEDURE: Bone Marrow Aspiration and Biopsy|DRUG: Cyclophosphamide|DRUG: Mercaptopurine|BIOLOGICAL: Rituximab|DRUG: Doxorubicin|DRUG: Thioguanine|BIOLOGICAL: Inotuzumab Ozogamicin|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Steady-State Trough Concentrations, Safety, and Immunogenicity of Abatacept After Subcutaneous (SC) Administration to Subjects With Rheumatoid Arthritis (RA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Abatacept or Placebo (both as IV & SC Solution)|DRUG: Abatacept or Placebo (both as IV & SC Solution)|DRUG: Abatacept or Placebo (both as IV & SC solution)|DRUG: Abatacept or Placebo (both as IV & SC solution)|DRUG: Abatacept or Placebo (both as IV & SC solution)|DRUG: Abatacept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Corneal Cross Linking and Topography Guided Excimer Laser Treatment
Status: TERMINATED
Conditions: Keratoconus|Pellucid Marginal Degeneration
Interventions: OTHER: Topography guided Excimer Laser treatment and Corneal Cross Linking|OTHER: Corneal Cross Linking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UHR-OCT and HD-OCT for Preretinal Membranes: ICG Versus Membrane Blue
Status: COMPLETED
Conditions: Retinal Diseases
Interventions: PROCEDURE: ppVE, MP, ICG|PROCEDURE: ppVE, MP, MB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Response of the Autonomic Nervous System to Auricular Stimulation of the Vagus Nerve (x)
Status: TERMINATED
Conditions: Vasoconstriction Disorder of Extremities
Interventions: BEHAVIORAL: stimulation of G13 then G15|BEHAVIORAL: stimulation of G15 then G13
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Creating an Innovative AI-based Technology TCRact for Designing and Optimizing T-cell Receptors (TCR) for Use in Cancer Immunotherapies
Status: COMPLETED
Conditions: Colon Cancer|Cancer
Interventions: OTHER: Collection of blood (PBMC), biopsy (FFPE) and stool samples.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Robotic Harvest of the Latissimus Dorsi (LD) Muscles
Status: COMPLETED
Conditions: Other Reconstructive Surgery|Failure of Muscle Graft|Cancer|Complications|Surgical Procedure, Unspecified
Interventions: DEVICE: da Vinci® Robotic Surgical System|PROCEDURE: LD muscle flap harvest procedure|PROCEDURE: Reconstructive surgery|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms
Status: NOT_YET_RECRUITING
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: pacritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study to Collect Safety Data and PROMs on Primary THA
Status: RECRUITING
Conditions: Hip Arthritis|Osteoarthritis, Hip|Coxitis|Femoral Head Necrosis|Femoral Neck Fractures
Interventions: DEVICE: Total hip arthroplasty with a Trinity cup and a Meije Duo cementless stem
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ASIS for Botox in Cervical Dystonia
Status: UNKNOWN
Conditions: Cervical Dystonia Adults ,|Abnormal Head Position and Neck Pain for These 7 Muscle Groups: Splenius,Scalene,Sterno-cleido-mastoid,Levator Scapulae,Semispinalis,Trapezius,and Longissimus.
Interventions: DRUG: Gadolinium|DRUG: Gadolinium|DRUG: Gadolinium|DRUG: Efficacy of Botox intramuscularly at Week 6|DRUG: Efficacy of Botox intramuscularly at Week 12|DRUG: Efficacy of Botox intramuscularly at Week 18|DRUG: Efficacy of Botox intramuscularly at Week 24|DRUG: Efficacy of Botox intramuscularly at Week 30|DRUG: Efficacy of Botox subdermally at Week 6|DRUG: Efficacy of Botox subdermally at Week 12|DRUG: Efficacy of Botox subdermally at Week 18|DRUG: Efficacy of Botox subdermally at Week 24|DRUG: Efficacy of Botox subdermally at Week 30|DRUG: Adverse Reactions of Botox intramuscularly|DRUG: Adverse Reactions of Botox subdermally
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging of Osteonecrosis With Ferumoxytol-Enhanced MRI
Status: ENROLLING_BY_INVITATION
Conditions: Osteonecrosis
Interventions: DRUG: Ferumoxytol-enhanced magnetic resonance imaging|DEVICE: Magentic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Vitamin D and Calcium Supplementation on Inflammatory Biomarkers and Adypocytokines in Diabetic Patients
Status: UNKNOWN
Conditions: Nutritional and Metabolic Disease
Interventions: DIETARY_SUPPLEMENT: vitamin D3 supplement|DIETARY_SUPPLEMENT: calcium supplement|DIETARY_SUPPLEMENT: vitamin D3 and calcium supplement|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Alzheimer Disease Proof of Concept Study With BI 409306 Versus Placebo
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: BI 409306|DRUG: Placebo|DRUG: BI 409306|DRUG: Placebo|DRUG: Placebo|DRUG: BI 409306|DRUG: BI 409306|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery
Status: UNKNOWN
Conditions: Infertility, Male|Varicocele
Interventions: DRUG: recombinant FSH
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of Pirfenidone in Combination With Nintedanib in Participants With Idiopathic Pulmonary Fibrosis (IPF)
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Nintedanib|DRUG: Pirfenidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Fecal Microbiota Transplantation in a Population With Obsessive-compulsive Disorder
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: COMBINATION_PRODUCT: FMT Capsule + SIMBA Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Isatidis Root and Forsythia Oral Liquid for the Treatment of Mild Cases of COVID-19: A Trial Clinical Study
Status: COMPLETED
Conditions: Treatment of Mild Cases of COVID-19
Interventions: DRUG: Langenlianqiao|DRUG: LianhuaQingWen|OTHER: placebo control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Indoor Air Pollution and Children With Asthma: An Intervention Trial
Status: COMPLETED
Conditions: Asthma
Interventions: OTHER: NO2 Scrubber|OTHER: HEPA filter|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ketone Ester Supplementation on Sleep and Recovery in Hypoxia
Status: COMPLETED
Conditions: Ketosis|Hypoxia|Sleep
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Ketone ester
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Antigravity Treadmill Training on Gait and Balance in Patients With Diabetic Polyneuropathy
Status: COMPLETED
Conditions: Diabetic Polyneuropathy
Interventions: OTHER: Antigravity treadmill training|OTHER: Conventional exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of a Single-Dose of PF-06651600 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: PF-06651600 10 mg tablets|DRUG: Itraconazole Solution 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cerebral NIRS Profiles During Premedication for Neonatal Intubation
Status: COMPLETED
Conditions: Premedication|Endotracheal Intubation|Cerebral Hypoperfusion
Interventions: DRUG: atropine+ propofol|DRUG: atropine + atracurium + sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT