pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study to Assess Safety and Efficacy of Atezolizumab (MPDL3280A) Compared to Best Supportive Care Following Chemotherapy in Patients With Lung Cancer [IMpower010]
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Atezolizumab|DRUG: Cisplatin|DRUG: Vinorelbine|DRUG: Docetaxel|DRUG: Gemcitabine|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease
Status: RECRUITING
Conditions: Sickle Cell Disease
Interventions: DRUG: Nicotinamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Early Ultrasound-guided Femoral Nerve Block Performed by Emergency Physicians on Pre-operative Opioids Usage in Patients With Proximal Femoral Fractures
Status: COMPLETED
Conditions: Femoral Fracture|Femoral Nerve Block
Interventions: OTHER: Standard pain management|OTHER: Femoral nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Trial of a Network Intervention for Youth After Incarceration
Status: TERMINATED
Conditions: Youth Incarceration|Health Care Utilization
Interventions: BEHAVIORAL: Whole Person Care (WPC) Reentry Program - Pre & Post Release services
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Safety of CSJ117 in Participants With Moderate to Severe Uncontrolled Asthma
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: CSJ117|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Controlled Trial to Evaluate CT Image Quality Lumentin® 44
Status: TERMINATED
Conditions: Subjects Referred to CT-examination of the Abdomen
Interventions: DIAGNOSTIC_TEST: Lumentin® 44|DIAGNOSTIC_TEST: Diluted Omnipaque®|DIAGNOSTIC_TEST: Movprep®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: MalnutritiOn Assessment With biOelectrical impedaNce Analysis in gastRic Cancer patIentS Undergoing Multimodal trEatment
Status: RECRUITING
Conditions: Gastric Cancer|Gastric Adenocarcinoma|Malnutrition|Cachexia
Interventions: OTHER: Observational Survey
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Liposomal Bupivacaine/Bupivacaine in RS Blocks vs. Ropivacaine in RS Blocks And Catheters
Status: RECRUITING
Conditions: Aortic Aneurysm, Abdominal|Abdominal Aortic Occlusion|Aortoiliac Occlusive Disease|Aortic Diseases
Interventions: DRUG: Liposomal bupivacaine|DRUG: Ropivacaine|DRUG: Bupivacain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Modafinil to Prevent Postoperative Cognitive Decline
Status: COMPLETED
Conditions: Postoperative Cognitive Dysfunction
Interventions: DRUG: Preoperative modafinil + postoperative placebo|DRUG: Preoperative modafinil + postoperative modafinil|DRUG: Preoperative placebo + postoperative placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Involvement of Immune Cells Derived From the Intestine in Sjogren's Syndrome
Status: RECRUITING
Conditions: Sjogren's Syndrome
Interventions: BIOLOGICAL: blood sample|BIOLOGICAL: biopsy of the labial salivary gland
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Trial Comparing the Effects of Aripiprazole With Those of Standard of Care on Non-HDL Cholesterol in Patients With Schizophrenia or Bipolar I Disorder Who Have Metabolic Syndrome
Status: TERMINATED
Conditions: Schizophrenia|Schizoaffective Disorder|Bipolar I Disorder|Metabolic Syndrome
Interventions: DRUG: Aripiprazole|DRUG: Oanzapine, risperidone, or quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ICP-488 in Patients With Moderate to Severe Plaque Psoriasis
Status: RECRUITING
Conditions: Moderate to Severe Plaque Psoriasis
Interventions: DRUG: ICP-488 Tablets|DRUG: ICP-488 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Intervention in Diabetes Mellitus (DIDM)- Intermediate and Acute Effects
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: Low Glycemic Index (LGI) intervention arm|OTHER: Standard Diet Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Potential Preventive Effect of Selenium on Iodine-induced Thyroid Autoimmunity During Pregnancy
Status: UNKNOWN
Conditions: Pregnancy|Thyroid Autoimmune Disease|Iodine Deficiency|Selenium Deficiency
Interventions: DIETARY_SUPPLEMENT: Iodine|DIETARY_SUPPLEMENT: Iodine + Selenium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transcranial Direct Current Stimulation to Enhance Rehabilitation in Individuals With Rotator Cuff Tendinopathy
Status: COMPLETED
Conditions: Rotator Cuff Tendinopathy
Interventions: OTHER: tDCS group|OTHER: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Drug Dimethoxbenzylidene Anabaseine in Treating Schizophrenia Patients
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders
Interventions: DRUG: Dimethoxybenzylidene anabaseine (DMXB-A)|DRUG: Placebo|DRUG: Dimethoxybenzylidene anabaseine (DMXB-A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selective Intraoperative Administration of Local Anesthesia in Breast Reconstruction
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Saline|DRUG: 0.25 % bupivacaine (2.5 mg/ml) w/ 1:100,000 epinephrine & 4 mg dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Immunogenicity of Concomitant vs Sequential mRNA COVID-19 and Influenza Vaccinations
Status: COMPLETED
Conditions: Influenza|COVID-19
Interventions: BIOLOGICAL: Simultaneous Vaccination (Influenza Vaccine and mRNA COVID booster)|BIOLOGICAL: Sequential Vaccination (Influenza vaccine then mRNA COVID booster)|BIOLOGICAL: Sequential Vaccination (mRNA COVID booster then Influenza vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Adjuvant Chemotherapy in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Cisplatin,fluorouracil|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Rimonabant, on Weight and Metabolic Risk Factors
Status: TERMINATED
Conditions: Schizophrenia|Schizoaffective Disorder|Obesity|Hypertension|Smoking
Interventions: DRUG: Rimonabant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Arm Phase I Trail of Autologous Tumor Infiltrating Lymphocyte Injection (GT202) in the Treatment of Metastatic or Recurrent Gynecological Tumors
Status: RECRUITING
Conditions: Metastatic or Recurrent Gynecological Tumors
Interventions: BIOLOGICAL: Autologous Tumor Infiltrating Lymphocyte Injection (GT202)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanistic Characterization of Uterine Pain
Status: RECRUITING
Conditions: Dysmenorrhea (Disorder)|Dysmenorrhea Primary|Dysmenorrhea Secondary|Endometrial Diseases|Leiomyoma|Fibroid Uterus
Interventions: DRUG: Naproxen Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Tolerability Study of Panosyl-Isomaltooligosaccharides (PIMO) and a Placebo in Subjects With Heartburn
Status: COMPLETED
Conditions: Heartburn
Interventions: DIETARY_SUPPLEMENT: Panosyl-isomaltooligosaccharides (PIMO) 1g (1.4 ml)|OTHER: Placebo 1.4 ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: An Analysis of the Improvement and Quality of Life Trends for UK/ROI Patients Treated With Cosentyx (Secukinumab) in a Retrospective Analysis of the BADBIR Data Source
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: OTHER: Secukinumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Multi-component Interventions on Populations With Mental Health Symptoms and High-risk COPD
Status: NOT_YET_RECRUITING
Conditions: Multimorbidity|Mental Health Issue|Multi-component Interventions
Interventions: COMBINATION_PRODUCT: Multi-component Interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Novel Treatment of Advanced Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: HCC
Interventions: DRUG: Anlotinib Hydrochloride Capsules|DRUG: Arginine hydrochloride|DRUG: levamisole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)
Status: RECRUITING
Conditions: Transthyretin-Mediated Amyloidosis|ATTR Amyloidosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Proton Pump Inhibitor and Polaprezinc Combination Therapy for Healing of Endoscopic Submucosal Dissection-induced Ulcer
Status: COMPLETED
Conditions: Gastric Adenoma|Early Gastric Cancer
Interventions: DRUG: Polaprezinc|DRUG: Rebamipide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Biphasic Human Insulin 30 With Biphasic Insulin Aspart in Subjects With Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart 50|DRUG: biphasic insulin aspart 70|DRUG: biphasic human insulin 30
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy and Pharmacokinetics of Subcutaneous ACZ885 in Patients With Systemic Juvenile Idiopathic Arthritis (SJIA)
Status: COMPLETED
Conditions: Arthritis, Juvenile Rheumatoid
Interventions: DRUG: ACZ885
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective, Randomized Study of 2 Different Wound Dressings
Status: COMPLETED
Conditions: Hip-surgery|Knee-surgery|Spinal-surgery
Interventions: DEVICE: Mepilex® Border Post-Op|DEVICE: standard wound dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sphenopalatine Block or Epidural Bloodpatch for Post Dural Puncture Headache: Randomized Controlled Trial
Status: TERMINATED
Conditions: Post-Dural Puncture Headache
Interventions: PROCEDURE: Sphenopalatine ganglion block|PROCEDURE: Epidural blood patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Assess The Efficacy and Safety of HH-120 Nasal Spray for the Treatment of Mild COVID-19
Status: RECRUITING
Conditions: COVID-19
Interventions: DRUG: HH-120 nasal spray|DRUG: HH-120 nasal spray|DRUG: Placebo Comparator|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BTA vs Baclofen for Pelvic Myofascial Pain Syndrome
Status: RECRUITING
Conditions: Chronic Pain|Chronic Pelvic Pain Syndrome|Myofascial Pain Syndrome|Myofascial Trigger Point Pain|Pelvic Floor Disorders
Interventions: DRUG: Baclofen 10mg|DRUG: Botulinum toxin type A
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Enhancing Language Function in Primary Progressive Aphasia
Status: RECRUITING
Conditions: Primary Progressive Aphasia
Interventions: COMBINATION_PRODUCT: tDCS + language therapy|COMBINATION_PRODUCT: sham TDCS + language therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Composite Cartilage Perichondrium Graft for Air Bone Gap Closure in Chronic Suppurative Otitis Media (CSOM) Without Posterior Meatal Flap
Status: UNKNOWN
Conditions: Tympanic Membrane Perforation
Interventions: OTHER: Endoscopic ear surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Dose Escalation Study of Bivatuzumab Mertansine in Patients With Advanced Squamous Cell Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Head and Neck Neoplasms
Interventions: DRUG: bivatuzumab mertansine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Delgocitinib Cream in Adolescents 12-17 Years of Age With Moderate to Severe Chronic Hand Eczema
Status: RECRUITING
Conditions: Chronic Hand Eczema
Interventions: DRUG: Delgocitinib|DRUG: Cream vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Radiotherapy's Effect on One and Two Stages Prosthetic Breast Reconstruction and on Autologous Reconstruction
Status: COMPLETED
Conditions: Mammaplasty|Radiotherapy; Complications|Breast Implant; Complications|Transplant Failure
Interventions: RADIATION: Adjuvant Radiotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 1:1 Comparison of the Pocket Colposcope in Kenya
Status: RECRUITING
Conditions: Cervical Cancer|HPV Infection|HIV Infections
Interventions: DEVICE: Pocket Colposcope|PROCEDURE: Standard of Care Colposcopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Radiation Plus Cetuximab in Locally Advanced Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Cabazitaxel, Mitoxantrone, and Prednisone Metastatic Castration-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: Cabazitaxel|DRUG: Mitoxantrone|DRUG: Prednisone|DRUG: Pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Duration of Effect of Acidform Gel on Vaginal pH
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Acidform 5 g|DRUG: Placebo 4 g|DRUG: Acidform 4 g|DRUG: Acidform 3 g
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Transcranial Electrical Stimulation (tES) on Emotion Processing
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Transcranial alternating current stimulation (tACS) -active|DEVICE: Transcranial direct current stimulation (tDCS)-active|DEVICE: Transcranial electrical stimulation (TES)-sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: HD10 for Early Stages
Status: COMPLETED
Conditions: Hodgkin´s Lymphoma
Interventions: DRUG: Adriamycin|DRUG: Bleomycin|DRUG: Vinblastine|DRUG: DTIC|RADIATION: 30 Gy IF-RT|RADIATION: 20 Gy IF-RT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Novel Sperm Selection Method Provides Advantages Over Conventional Approaches
Status: COMPLETED
Conditions: Male Infertility
Interventions: DEVICE: Density Gradient Centrifugation|DEVICE: CA0 chamber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock
Status: COMPLETED
Conditions: Septic Shock|Fluid Therapy|Hypotension
Interventions: OTHER: Fluid minimization protocol|DEVICE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peripheral Blood Stem Cell Combined With Mesenchymal Stem Cells for Treatment of Poor Graft Function
Status: UNKNOWN
Conditions: Stem Cell Transplantation, Hematopoietic|Poor Graft Function|Hematological Diseases
Interventions: BIOLOGICAL: PBSC|BIOLOGICAL: MSCs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pulse Radiofrequency Treatment in Patients With Coxarthrosis
Status: COMPLETED
Conditions: Coxarthrosis; Primary
Interventions: DEVICE: Pulse radiofrequency treatment|DRUG: Nerve block with 1 cc betamethasone and 1 cc 1% lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Using MASTER to Perform Endoscopic Submucosal Dissection in Human
Status: UNKNOWN
Conditions: Gastric Cancer|Colon Cancer
Interventions: DEVICE: Endoscopic submucosal dissection (ESD) using device, MASTER
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: End Tidal Carbon Dioxide Concentration and Depth of Anesthesia in Children
Status: NOT_YET_RECRUITING
Conditions: Anesthesia|Hypercapnia|Hypocapnia
Interventions: OTHER: High normal ETCO2: ETCO2 50 mmHg (+/- 3mmHg)|OTHER: Normal ETCO2: ETCO2 40 mmHg (+/- 3mmHg)|OTHER: Low Normal ETCO2: ETCO2 30 mmHg (+/- 3mmHg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: The Impact of a Humor Seminar on General Well Being, Quality of Life and Psychological Distress Among Community Dwelling Elders
Status: COMPLETED
Conditions: Improve Mental Health
Interventions: BEHAVIORAL: Humor as a Way of Life Seminar
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Contribution of Intrathecal Morphine Administration to Postoperative Patient Satisfaction During Cesarean Delivery
Status: COMPLETED
Conditions: Cesarean Section|Intrathecal Morphine|Quality of Recovery 40
Interventions: DRUG: Group morphine|OTHER: Group placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessing the Endometrial Environment in Recurrent Pregnancy Loss and Unexplained Infertility
Status: COMPLETED
Conditions: Recurrent Pregnancy Loss|Unexplained Infertility
Interventions: DIAGNOSTIC_TEST: Uterine ERA and microbiome testing|DRUG: Oral antibiotics and vaginal probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NT-I7 for Kaposi Sarcoma in Patients With or Without HIV
Status: TERMINATED
Conditions: AIDS-Related Kaposi Sarcoma|HIV Infection|Kaposi Sarcoma
Interventions: BIOLOGICAL: Efineptakin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Honey For CIN II
Status: NOT_YET_RECRUITING
Conditions: Cervical Intraepithelial Neoplasia-II|High Risk Human Papillomavirus
Interventions: OTHER: Medical grade honey formulation (MGH) (L-Mesitran®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Doses of JNJ-38431055, Sitagliptin, and Co-administration of JNJ-38431055 and Sitagliptin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: JNJ-38431055|DRUG: Sitagliptin 100 mg|DRUG: JNJ-38431055 + Sitagliptin 100 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety, Tolerability and Pharmacokinetics of Intravenous FL058 Administered in Healthy Subjects(SAD)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: FL058|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase Ib/II Trials of RAD001 in Triple Negative Metastatic Breast Cancer
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: RAD001|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Procalcitonin Guided Versus Conventional Antibiotic Therapy in Patients With Sepsis in the ICU
Status: WITHDRAWN
Conditions: Sepsis|Intensive Care
Interventions: OTHER: Procalcitonin measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: High Frequency Oscillatory Ventilation Combined With Intermittent Sigh Breaths: Effects on Lung Volume Monitored by Electric Tomography Impedance.
Status: COMPLETED
Conditions: Respiratory Distress Syndrome In Premature Infants|Bronchopulmonary Dysplasia|Ventilator-Induced Lung Injury|Functional Residual Capacity
Interventions: OTHER: HFOV combined with sigh breaths
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Sexual Counseling With the PLISSIT Model on Sexual Function and Sexual Quality of Life in Women With Multiple Sclerosis: A Randomized Controlled Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis|Female Sexual Dysfunction
Interventions: OTHER: sexual counselling with PLISSIT model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Impact of Preoperative Bowel Exercise on Postoperative Bowel Functions in Gynecologic Malignancies
Status: COMPLETED
Conditions: Paralytic Ileus|Nausea|Defecation Disorder
Interventions: PROCEDURE: Abdominal Exercise (digital rectal stimulation, abdominal massage)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Telemonitoring Platform "CUREETY TECHCARE" vs Standard of Care for mTBNC Patients Initiating a First-line Treatment
Status: RECRUITING
Conditions: Metastatic Triple-Negative Breast Carcinoma
Interventions: DEVICE: Cureety techcare
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Anlotinib Combined With TACE in Hepatocellular Carcinoma Patients at High Risk of Post Surgery Recurrence
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma|TACE|Anlotinib
Interventions: DRUG: Anlotinib Hydrochloride|PROCEDURE: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ziprasidone vs Standard Therapy for Agitated Patients in the ED
Status: WITHDRAWN
Conditions: Psychosis|Agitation|Delirium
Interventions: DRUG: ziprasidone|DRUG: Standard therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab, Bevacizumab, and Cyclophosphamide in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Fallopian Tube Clear Cell Adenocarcinoma|Fallopian Tube Endometrioid Adenocarcinoma|Fallopian Tube Mucinous Adenocarcinoma|Fallopian Tube Serous Adenocarcinoma|Ovarian Clear Cell Adenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian Mucinous Adenocarcinoma|Ovarian Serous Adenocarcinoma|Primary Peritoneal Serous Adenocarcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Undifferentiated Fallopian Tube Carcinoma|Undifferentiated Ovarian Carcinoma
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Cyclophosphamide|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Fedratinib in Subjects With DIPSS, Intermediate or High-Risk Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib
Status: COMPLETED
Conditions: Primary Myelofibrosis|Post-Polycythemia Vera Myelofibrosis|Myelofibrosis|Post-essential Thrombocythemia Myelofibrosis
Interventions: DRUG: FEDRATINIB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Dexmedetomidine Hydrochloride Nasal Spray in Preoperative Sedation of Adults
Status: UNKNOWN
Conditions: Preoperative Sedation
Interventions: DRUG: dexmedetomidine nasal spray|DRUG: dexmedetomidine hydrochloride nasal spray blank preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nutrition360: Moving to Integrated and Holistic Disease Prevention Among Underserved Mississippians
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases
Interventions: BEHAVIORAL: Psychosocial Intervention|OTHER: Structural Intervention|OTHER: Traditional Psychosocial+Structural|OTHER: Integrated Psychosocial+Structural
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Tranilast Alone or in Combination With Febuxostat in Patients With Hyperuricemia
Status: COMPLETED
Conditions: Gout|Hyperuricemia
Interventions: DRUG: Tranilast|DRUG: Febuxostat|DRUG: Combination - Tranilast and Febuxostat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Alpha-lactalbumin on Microbiota Composition
Status: COMPLETED
Conditions: Alpha-lactalbumin|Microbiota|Dysbiosis
Interventions: DIETARY_SUPPLEMENT: Alpha-lactalbumin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of the Effectiveness and Safety of Different Doses of Fluticasone Propionate Taken From a Dry Powder Inhaler (Puffer) in Adolescents and Adults Who Have Asthma That is Not Controlled by High Dose Inhaled Corticosteroid Asthma Medications
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fp MDPI|OTHER: Placebo MDPI|DRUG: Flovent Diskus|DRUG: albuterol/salbutamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of Plantar Orthoses for Abnormal Plantar Arch Using a New Non-invasive Clinical Imaging System
Status: ACTIVE_NOT_RECRUITING
Conditions: Flat Feet|High Arched Foot
Interventions: DEVICE: Foot orthosis for flat feet|DEVICE: Foot orthoses for high arches feet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Human Fibrin Glue Versus Staples for Mesh Fixation in Laparoscopic Transabdominal Preperitoneal Hernioplasty
Status: COMPLETED
Conditions: Hernia, Inguinal
Interventions: DRUG: Tissue glue|DEVICE: Staples
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Hemodialysis Catheter-Related Bacteremia
Status: WITHDRAWN
Conditions: Hemodialysis Catheter-related Bacteremia
Interventions: DRUG: tigecycline, N-acetylcysteine, heparin combination|DEVICE: guide-wire exchange
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose:
Clinical trial: Bioequivalence Study of Metformin Component of Canagliflozin and Metformin Fixed Dose Combination Immediate Release (IR) Tablet Comparing With Metformin IR Tablet Co-administered With Canagliflozin Tablet in Healthy Fed and Fasted Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Canagliflozin + Metformin Immediate Release (IR) Fixed Dose Combination (FDC)|DRUG: Canagliflozin|DRUG: Metformin IR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Vitamin B12 Supplementation to Selective Serotonin Reuptake Inhibitor (SSRI) Versus SSRI Antidepressant Treatment Alone
Status: UNKNOWN
Conditions: Major Depressive Disorder
Interventions: DIETARY_SUPPLEMENT: Vitamin B12
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing Virtual Reality for Perioperative Anxiolysis and Postoperative Pain Modulation in Adolescents Undergoing MIRPE Surgery
Status: RECRUITING
Conditions: Pectus Excavatum|Pectus Deformity
Interventions: DEVICE: Virtual reality exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Measure the Efficacy of a Toothpaste on Dentinal Hypersensitivity
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: DEVICE: CSSP Toothpaste|DEVICE: Fluoride Toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of IDP-73152 Mesylate in Health Male Volunteer
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: IDP-73152 mesylate 40 mg|DRUG: IDP-73152 mesylate 80 mg|DRUG: IDP-73152 mesylate 160 mg|DRUG: IDP-73152 mesylate 320 mg|DRUG: IDP-73152 mesylate 640 mg|DRUG: IDP-73152 mesylate 1280 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tremelimumab With Chemoembolization or Ablation for Liver Cancer
Status: COMPLETED
Conditions: Heptocellular Cancer|Biliary Tract Neoplasms|Liver Cancer|Hepatocellular Carcinoma|Biliary Cancer
Interventions: DRUG: Tremelimumab|PROCEDURE: RFA|PROCEDURE: TACE|PROCEDURE: Cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Consumption of a Fermented Milk on Common Infections in Adults Submitted to Multi-stressor Situation
Status: TERMINATED
Conditions: Upper Respiratory Tract Infections|Rhinopharyngitis|Sore Throat|Sinusitis|Otitis|Lower Respiratory Tract Infections|Bronchitis|Pneumopathy|Flu|Flu-like Syndromes|Gastroenteritis
Interventions: OTHER: 1-Fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel®)|OTHER: 2-Non fermented dairy product (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma
Status: RECRUITING
Conditions: Classic Follicular Lymphoma|Follicular Lymphoma With Unusual Cytological Features
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|BIOLOGICAL: Mosunetuzumab|PROCEDURE: Positron Emission Tomography|BIOLOGICAL: Rituximab|BIOLOGICAL: Rituximab and Hyaluronidase Human
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HRME in the Screening of Cervical Cancer Precursor Lesions in Brazil (UH3 - Brazil)
Status: UNKNOWN
Conditions: Intraepithelial Neoplasia|Intraepithelial Neoplasm, Cervical|Cervical Cancer|Neoplasm Cervix
Interventions: DEVICE: HRME examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Melanoma
Status: TERMINATED
Conditions: Metastatic Melanoma|Skin Cancer
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|BIOLOGICAL: Young Tumor Infiltrating Lymphocytes (TIL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Chemoradiotherapy With Nimotuzumab in Unresectable Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer|Chemoradiotherapy|Nimotuzumab|Unresectable Malignant Neoplasm
Interventions: RADIATION: Radiotherapy|DRUG: Nimotuzumab|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Same-Day Mifepristone-Misoprostol Compared to Misoprostol Only for Surgical Abortion Cervical Preparation
Status: COMPLETED
Conditions: Induced Abortion
Interventions: DRUG: Mifepristone|DRUG: Misoprostol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Peer Support Program in Chronic Kidney Patient
Status: ACTIVE_NOT_RECRUITING
Conditions: Peer Review|Hemodialysis Complication|Nurse's Role|Health-Related Behavior
Interventions: BEHAVIORAL: The Peer Support Program|BEHAVIORAL: Standart care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Belatacept (Nulojix) in Renal Transplant Recipient With Mild Immunologic Risk Factor: a Pilot Prospective Study.
Status: COMPLETED
Conditions: Renal Transplant|Acute Antibody Mediated Rejection|Mild Immunologic Risk Factor
Interventions: DRUG: Nulojix (Belatacept)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crizanlizumab Alone or in Combination With Nivolumab for Glioblastoma and Melanoma With Brain Metastases
Status: RECRUITING
Conditions: Advanced Glioblastoma|Metastatic Melanoma in the Central Nervous System|MGMT-Unmethylated Glioblastoma
Interventions: DRUG: Crizanlizumab-Tmca 10 MG/1 ML Intravenous Solution [ADAKVEO]|DRUG: Nivolumab 10 MG/1 ML Intravenous Solution [OPDIVO]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mosunetuzumab and Polatuzumab Vedotin for Untreated Follicular Lymphoma
Status: RECRUITING
Conditions: Lymphoma, Follicular|Follicular Lymphoma
Interventions: DRUG: Mosunetuzumab|DRUG: Polatuzumab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label, Phase II, Study of Everolimus Plus Letrozole in Postmenopausal Women With ER+, HER2- Metastatic or Locally Advanced Breast Cancer
Status: COMPLETED
Conditions: Hormone Receptor Positive Breast Cancer
Interventions: DRUG: Everolimus|DRUG: Letrozole|DRUG: Exemestane|DRUG: Alcohol-free dexamethasone mouth rinse (Stomatitis sub-study)|DRUG: Standard of care to treat stomatitis (Stomatitis sub-study)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Flow Oxygen in Patients Undergoing Suspension Laryngoscopy Under General Anesthesia
Status: TERMINATED
Conditions: Laryngoscopy|Apnea|Anesthesia
Interventions: DEVICE: Nasal High Flow Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prognosis of Low-grade Endometrial Stromal Sarcoma
Status: RECRUITING
Conditions: Low Grade Endometrial Stromal Sarcoma of Uterus (Diagnosis)|Fertility-sparing Surgery|Survival Outcomes|Fertility Outcomes|Recurrence|Hormone Therapy|Adjuvant Therapy
Interventions: PROCEDURE: Surgical treatment with and without fertility-sparing procedures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Develop a Non-invasive Marker for Monitoring Myocardial Fibrosis
Status: TERMINATED
Conditions: Hypertrophic Cardiomyopathy|Acute Coronary Syndrome
Interventions: RADIATION: 99mTc-NC100692
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Relative Bioavailability of an Extemporaneous Oral Suspension of Aprepitant in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Chemotherapy-induced Nausea and Vomiting
Interventions: DRUG: Aprepitant Capsule 125 MG|DRUG: Aprepitant oral suspension 20 mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The CATT Trial: Cost-effectiveness of a Smartphone Application for Tinnitus Treatment
Status: RECRUITING
Conditions: Tinnitus
Interventions: OTHER: Standard Clinical care|DEVICE: Blended physiotherapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ)
Status: COMPLETED
Conditions: Malaria,Falciparum|Children, Only
Interventions: BIOLOGICAL: RABIPUR®|BIOLOGICAL: RTS,S/AS01|DRUG: SMC with SP+AQ|DRUG: SMC placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Aging Stereotypes and Prodromal Alzheimer's Disease
Status: UNKNOWN
Conditions: Mild Cognitive Impairment (MCI)
Interventions: DIAGNOSTIC_TEST: Diagnosis of MCI versus No MCI (SCI or healthy patient)|DIAGNOSTIC_TEST: Diagnosis of MCI versus No MCI (SCI or healthy patient)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: PRotective Effect on the Coronary Microcirculation of Patients With DIabetes by Clopidogrel or Ticagrelor
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: PROCEDURE: Diagnostic|DRUG: Randomization|PROCEDURE: PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy With or Without Surgery in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: systemic chemotherapy|PROCEDURE: adjuvant therapy|PROCEDURE: quality-of-life assessment|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparative Bioavailability Study of Eplerenone 50 mg Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Eplerenone 50 mg Tablets Sandoz Inc., USA|DRUG: Inspra 50 mg Tablets GD Searle LLC, USA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expanded Hemodialysis Versus Online Hemodiafiltration
Status: COMPLETED
Conditions: Dialysis Related Complication|Dialysis Hypotension|Hemodialysis-Induced Symptom
Interventions: DEVICE: Expanded Hemodialysis|DEVICE: Online Hemodiafiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of External Neuromodulation to Improve Signs and Symptoms of Dry Eye in Visual Display Terminal Users
Status: UNKNOWN
Conditions: Visual Display Users With Previously Undiagnosed Dry Eye
Interventions: DEVICE: iTEAR100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Lanthanum Carbonate and Sevelamer Hydrochloride in Patients Receiving Haemodialysis for End Stage Renal Disease
Status: COMPLETED
Conditions: Kidney Failure, Chronic
Interventions: DRUG: Lanthanum carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Buccal Midazolam Versus Intranasal Dexmedetomidine Plus Oral Chloral Hydrate in Inguinal Hernia Repair
Status: COMPLETED
Conditions: Inguinal Hernia Repair
Interventions: DRUG: buccal midazolam +oral placebo syrup|DRUG: oral chloral hydrate,intranasal dexmedetomidine and buccal normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Impact of Personalized Feedback Alone on Substance Use Behaviors
Status: COMPLETED
Conditions: Substance Abuse
Interventions: BEHAVIORAL: Personalized feedback report|BEHAVIORAL: Personalized feedback report plus education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Elective Abdominal Aortic Aneurism - Open Versus Endovascular Repair
Status: COMPLETED
Conditions: Elective Abdominal Aortic Aneurysm
Interventions: PROCEDURE: Endovascular repair (with endograft)|PROCEDURE: Open repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduction of LDL-C With PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder Study-2
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: BIOLOGICAL: Evolocumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Study of Fostamatinib Disodium in the Treatment of wAIHA
Status: COMPLETED
Conditions: Warm Antibody Autoimmune Hemolytic Anemia
Interventions: DRUG: Fostamatinib disodium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Phase 2 Study of Cemiplimab ± ISA101b in HPV16-Positive OPC
Status: ACTIVE_NOT_RECRUITING
Conditions: Squamous Cell Carcinoma of the Oropharynx|HPV16 Positive
Interventions: BIOLOGICAL: ISA101b|DRUG: Cemiplimab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sintilimab and Nab-paclitaxel in Second-line Treatment of Advanced Gastric or Gastro-oesophageal Junction Adenocarcinoma
Status: UNKNOWN
Conditions: Advanced Gastric and Gastro-esophageal Junction Adenocarcinoma
Interventions: DRUG: sintilimab|DRUG: nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Arm Recovery in Stroke Patients With Hand Paralysis
Status: COMPLETED
Conditions: Stroke|Hemiparesis|Cerebral Vascular Accident|Stroke, Ischemic
Interventions: PROCEDURE: Unaffected Transcranial Magnetic Stimulation|PROCEDURE: Affected Transcranial Magnetic Stimulation|PROCEDURE: Control Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT