pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Abatacept Versus Placebo to Assess the Prevention of Rheumatoid Arthritis (RA) in Adult Patients
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Abatacept|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Study to Assess the Safety, Tolerability, and Pharmacodynamics of RTA 402 in Patients With Hepatic Dysfunction
Status: TERMINATED
Conditions: Liver Disease
Interventions: DRUG: RTA 402|DRUG: RTA 402|DRUG: RTA 402
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Franciscus Obesity NASH Study
Status: NOT_YET_RECRUITING
Conditions: NAFLD|NASH - Nonalcoholic Steatohepatitis|Obesity, Morbid
Interventions: DIAGNOSTIC_TEST: NASH screening|DIAGNOSTIC_TEST: Cardiac dysfunction screening|DIAGNOSTIC_TEST: Liver biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Intrathecal Magnesium Sulfate on Shivering
Status: COMPLETED
Conditions: Magnesium Sulfate Causing Adverse Effects in Therapeutic Use|Postoperative Shivering|Cesarean Section Complications
Interventions: DRUG: 25 mg MgSO4 (Magnezyum Sulfat %15, Biofarma, Istanbul, Turkey)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Androgen Deprivation Therapy +/- Radium-223 Dichloride in Metastatic Prostate Cancer With Bone Metastases
Status: TERMINATED
Conditions: Prostate Cancer|Bone Metastases|Prostate Neoplasms
Interventions: DRUG: LHRH agonist/antagonist|DRUG: Bicalutamide|RADIATION: Radium-223 dichloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Percutaneous Tracheostomy
Status: COMPLETED
Conditions: Reliability of the Ultrasound in Percutaneous Tracheostomy
Interventions: PROCEDURE: ultrasound-guided percutaneous tracheostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of DHA Supplements on Macular Function in Patients With Stargardt Macular Dystrophy and Stargardt-like Macular Dystrophy
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DRUG: Docosahexaenoic Acid (DHA) Dietary Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Extremity Manipulation Impact on Postural Sway Characteristics
Status: COMPLETED
Conditions: Healthy
Interventions: PROCEDURE: Lower Extremity First (LEF)|PROCEDURE: Upper Extremity First (UEF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coolsense and Buzzy Use on Pain Score and Anxiety Level During Insulin Injection Application
Status: NOT_YET_RECRUITING
Conditions: Injection Fear|Injection Site Coldness|Pain|Type 1 Diabetes Mellitus|Pediatric Disease|Nurse's Role
Interventions: DEVICE: Coolsense and Buzzy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Helminth-induced Immunomodulation Therapy (HINT) in Relapsing-remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: BIOLOGICAL: Helminth ova
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Omalizumab in Patients With Severe Persistent Non-atopic Uncontrolled Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: omalizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intermittent or Continuous Acetylsalicylic Acid and Gene Expression in the Nasal Tissue of Current Smokers
Status: COMPLETED
Conditions: Lung Carcinoma|Tobacco Use Disorder
Interventions: DRUG: Aspirin|OTHER: Laboratory Biomarker Analysis|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety Study of Combined Chemotherapy and Endostar to Untreated Patients With Advanced Melanoma
Status: UNKNOWN
Conditions: Advanced Melanoma|Untreated Patients
Interventions: DRUG: dacarbazine plus Endostar (Experimental group)|DRUG: dacarbazine plus placebo (control group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab (MK-3475) Versus Investigator's Choice of Chemotherapy for Participants With Advanced Esophageal/Esophagogastric Junction Carcinoma That Progressed After First-Line Therapy (MK-3475-181/KEYNOTE-181)-China Extension Study
Status: COMPLETED
Conditions: Esophageal Carcinoma|Esophagogastric Junction Carcinoma
Interventions: BIOLOGICAL: pembrolizumab|DRUG: paclitaxel|DRUG: docetaxel|DRUG: irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spironolactone and Prevention of Peritoneal Fibrosis in Peritoneal Dialysis
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DRUG: spironolactone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Problem-solving-based Bibliotherapy Program for Family Caregivers
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders
Interventions: BEHAVIORAL: Self-learning program|BEHAVIORAL: Psycho-education program (in Phase 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate ALN-HTT02 in Adult Patients With Huntington's Disease
Status: NOT_YET_RECRUITING
Conditions: Huntington's Disease
Interventions: DRUG: ALN-HTT02|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Acute and Sub-acute Administration of Gluten on Extra-intestinal and Gastrointestinal Symptoms in Patients With Non-coeliac Gluten Sensitivity
Status: UNKNOWN
Conditions: NCGS|Gluten
Interventions: OTHER: Gluten|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Oxytocin on Behavior and Physiology in a Psychotherapy Setting
Status: COMPLETED
Conditions: Behavior|Anxiety
Interventions: DRUG: Placebo then intranasal oxytocin|DRUG: Intranasal oxytocin then placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Safety, Pharmacokinetics Anti-Drug Antibody and Anti-RSV Antibody After 2 Doses of Nirsevimab
Status: ACTIVE_NOT_RECRUITING
Conditions: Respiratory Syncytial Virus Infections
Interventions: DRUG: Nirsevimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Alteplase Compared to Tenecteplase in Patients With Acute Ischemic Stroke
Status: COMPLETED
Conditions: Stroke, Acute|Thromboses, Intracranial
Interventions: DRUG: Tenecteplase|DRUG: Alteplase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term Safety and Efficacy Study of Teriflunomide 7 mg or 14 mg in Patients With Relapsing-Remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Teriflunomide (HMR1726)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Use of 3D Printing Models in the Treatment of Tibial Plateau Fractures: a Randomized Clinical Trial
Status: RECRUITING
Conditions: Tibial Plateau Fracture
Interventions: PROCEDURE: Open reduction and internal fixation|PROCEDURE: Standard osteosynthesis planning|PROCEDURE: 3-D model osteosynthesis planning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Study of EN3835 (CCH-aaes) in Edematous Fibrosclerotic Panniculopathy (Cellulite)
Status: COMPLETED
Conditions: Edematous Fibrosclerotic Panniculopathy|Cellulite
Interventions: BIOLOGICAL: CCH-aaes|OTHER: Observation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Clinical Investigation Comparing Standard Wound Closure Technique With Drains (Control) to Standard Wound Closure Techniques With TissuGlu® and No Drains (Test) in Mastectomy
Status: COMPLETED
Conditions: Cancer, Breast
Interventions: DEVICE: Test - Standard Closure with TissuGlu Surgical Adhesive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Prospective, Multicenter Study for the Role of Primary Tumor Resection in Colorectal Cancer Patients With Asymptomatic, Synchronous Unresectable Metastasis
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: PROCEDURE: Systemic chemotherapy|PROCEDURE: primary tumor resection (PTR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Chemotherapy Combined With Nimotuzumab in Untreated Metastatic Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Stage IV Nasopharyngeal Carcinoma
Interventions: DRUG: cisplatin and 5-Fu combined with nimotuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dinoprostone vs Misoprostol Before LNG-IUD Insertion
Status: UNKNOWN
Conditions: IUD Insertion Pain
Interventions: DRUG: vaginal dinoprostone|DRUG: vaginal misoprostol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Trial of TC-510 In Patients With Advanced Mesothelin-Expressing Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Mesothelioma|Mesotheliomas Pleural|Mesothelioma, Malignant|Mesothelioma Peritoneum|Ovarian Cancer|Ovarian Serous Adenocarcinoma|Pancreatic Cancer|Pancreatic Adenocarcinoma|Colorectal Cancer|Triple Negative Breast Cancer|TNBC - Triple-Negative Breast Cancer|Ovarian Adenocarcinoma|Pancreatic Neoplasms|Colorectal Neoplasms|Ovarian Neoplasms|Cholangiocarcinoma|Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: TC-510|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Amount and Type of Dietary Carbohydrates on Risk for Cardiovascular Heart Disease and Diabetes
Status: COMPLETED
Conditions: Overweight|Cardiovascular Diseases
Interventions: BEHAVIORAL: High carbohydrate and low glycemic index (GI) diet|BEHAVIORAL: Low carbohydrate and low GI diet|BEHAVIORAL: High carbohydrate and high GI diet|BEHAVIORAL: Low carbohydrate and high GI diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Chemotherapy, Associated to Either Cetuximab or Bevacizumab, in KRAS Wild-type Metastatic Colorectal Cancer Patients With Progressive Disease After Receiving First-line Treatment With Bevacizumab
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Oxaliplatin|DRUG: Folinic Acid|DRUG: 5-fluoro-uracil|DRUG: Irinotecan|DRUG: Bevacizumab|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resistance Exercise in Children With Post-operative Congenital Diaphragmatic Hernia
Status: COMPLETED
Conditions: Hernias, Diaphragmatic, Congenital
Interventions: OTHER: chest resistance exercise|OTHER: chest expansion exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin and Docetaxel Followed by Cetuximab for Head and Neck Cancer
Status: TERMINATED
Conditions: Head and Neck Cancer|Carcinoma, Squamous
Interventions: DRUG: Oxaliplatin|DRUG: Docetaxel|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Four Medicines (Elranatamab Plus Carfilzomib and Dexamethasone or Maplirpacept) in People With Relapsed Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Elranatamab|DRUG: Carfilzomib|DRUG: Maplirpacept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Acute Intake of Meals Containing Higher vs. Lower Energy From Protein on DIT
Status: NOT_YET_RECRUITING
Conditions: Healthy|Overweight and Obesity
Interventions: OTHER: Higher protein|OTHER: Lower protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: COVID-19: Epidemiological Study of the Spread of SARS-CoV-2 in the Household of a Person Who Has Had a COVID-19 Disease
Status: COMPLETED
Conditions: Coronavirus Infection
Interventions: DIAGNOSTIC_TEST: COVID-19 IgG / IgM rapid test (whole blood, serum, plasma)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Hyperbilirubinemia in Full-term Neonates
Status: RECRUITING
Conditions: Hyperbilirubinemia, Neonatal
Interventions: DRUG: Oral bifidobacterium triple live powder|OTHER: Sunbathing|OTHER: Sunbathing and the Oral bifidobacterium triple live powder|OTHER: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate Safety & Efficacy of Sarecycline in Treatment of Acne
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Sarecycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adalimumab in Combination With Topical Treatment (Calcipotriol/Betamethasone) in Subjects With Moderate to Severe Psoriasis and Insufficient Response to Classic Systemic Treatment
Status: COMPLETED
Conditions: Chronic Plaque Psoriasis
Interventions: BIOLOGICAL: adalimumab|DRUG: Calcipotriol/Betamethasone Ointment|DRUG: placebo (vehicle ointment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-Dose or Standard-Dose Radiation Therapy and Chemotherapy With or Without Cetuximab in Treating Patients With Newly Diagnosed Stage III Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Lung Cancer|Radiation Toxicity
Interventions: BIOLOGICAL: Cetuximab|DRUG: Carboplatin|DRUG: Paclitaxel|RADIATION: 60 Gy RT|RADIATION: 74 Gy RT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Oral BAY 1217389 in Combination With Intravenous Paclitaxel
Status: COMPLETED
Conditions: Medical Oncology
Interventions: DRUG: BAY1217389|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibrutinib and Lenalidomide With Dose Adjusted EPOCH-R in Subjects With Relapsed/Refractory Diffuse Large B-cell Lymphoma
Status: COMPLETED
Conditions: Diffuse Large B Cell Lymphoma Relapsed|Diffuse Large B Cell Lymphoma Refractory
Interventions: DRUG: Ibrutinib|DRUG: DA-EPOCH-R|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Patient Compassionate Use / Expanded Access L-S-Gboxin (Lyophilized Form of S-Gboxin) for the Treatment of Diffuse Midline Glioma
Status: NO_LONGER_AVAILABLE
Conditions: DIPG Brain Tumor|Diffuse Brainstem Glioma|H3 K27M|H3 K28M|GBM
Interventions: DRUG: S-Gboxin
Study Type: EXPANDED_ACCESS
Clinical trial: IL-6 Regulation of Energy Stores During Recovery From an Acute Exercise Bout
Status: COMPLETED
Conditions: Glycogen Depletion
Interventions: DRUG: Tocilizumab/Actemra® (Roche)|DRUG: Saline 9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Exenatide (Byetta®) on Liver Function in Patients With Nonalcoholic Steatohepatitis (NASH)
Status: COMPLETED
Conditions: Nonalcoholic Fatty Liver Disease
Interventions: DRUG: Exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Alteration of Myocardial Deformations in Diabetes: Relationship to Micro-angiopathy
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DEVICE: Echocardiographic 2D strain analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Two Different Splints in the Treatment of Lateral Epicondylitis
Status: UNKNOWN
Conditions: Lateral Epicondylitis|Tennis Elbow
Interventions: DEVICE: Lateral Epicondylitis Bandage|DEVICE: Wrist Extension Splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Ultra-portable Ultrasound in General Practice
Status: COMPLETED
Conditions: Pneumonia|Pleural Effusion|Renal Colic|Hepatic Colic or Cholecystitis|Subcutaneous Abscess or Cyst|Fracture of Long Bones|Intra-uterine Pregnancy or Extra-uterine Pregnancy or Miscarriage|Phlebitis
Interventions: DIAGNOSTIC_TEST: Ultrasound scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study for the Participants With Metastatic Hormone Sensitive Prostate Cancer (mHSPC) Treated With Androgen Deprivation Therapy (ADT) Plus Apalutamide or Enzalutamide
Status: RECRUITING
Conditions: Metastatic Hormone-sensitive Prostate Cancer
Interventions: DRUG: Apalutamide|DRUG: Enzalutamide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sirolimus for Nosebleeds in HHT
Status: ACTIVE_NOT_RECRUITING
Conditions: Hereditary Hemorrhagic Telangiectasia|Nosebleeds|Epistaxis
Interventions: DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-operative Carbohydrates in Diabetic Patients Undergoing CABG
Status: UNKNOWN
Conditions: Insulin Resistance|Diabetes Mellitus, Type 2|Coronary Artery Bypass Surgery
Interventions: DIETARY_SUPPLEMENT: carbohydrates
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Alternating Current Stimulation Combined With 40Hz Sound Stimulation for Treatment Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: DEVICE: tACS combined with 40 Hz sound stimulation|DEVICE: Transcranial alternating current stimulation|DEVICE: 40 Hz sound stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PSMA and C-11 Choline PET in Patients With Biochemical Recurrence of Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Ga-68 PSMA11|DRUG: F-18 PSMA 1007
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Varenicline Adjunctive Treatment in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder
Interventions: DRUG: Varenicline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral Weight Loss for Cancer Survivors in Maryland: A Trial With Adaptive Interventions
Status: RECRUITING
Conditions: Weight Loss
Interventions: BEHAVIORAL: CORE Helpline|BEHAVIORAL: Extended Helpline|BEHAVIORAL: Enhanced Helpline|BEHAVIORAL: Intensive Helpline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Cytisinicline for Smoking Cessation in Adult Smokers
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Cytisinicline|DRUG: Placebo|BEHAVIORAL: Behavioral support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prednisone Versus Tamoxifen in Idiopathic Retroperitoneal Fibrosis
Status: UNKNOWN
Conditions: Retroperitoneal Fibrosis
Interventions: DRUG: Tamoxifen|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Study of Genotropin (Somatropin) for Short Children Born Small for Gestational Age (SGA)
Status: COMPLETED
Conditions: Short Stature Born Small for Gestational Age (SGA)
Interventions: DRUG: Genotropin (somatropin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Sensory Stimulative Activities on Sleep Performance in Elderly Adults: A Single-case Design
Status: UNKNOWN
Conditions: Sleep Disturbance
Interventions: BEHAVIORAL: Sensory Stimulative Activitiy ( proprioceptive intervention, music intervention )
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atorvastatin and LDL Profile in Non-Insulin Dependent Diabetes Mellitus
Status: TERMINATED
Conditions: Hyperlipidemia|Diabetes Mellitus, Type 2|Non-Insulin Dependent Diabetes Mellitus
Interventions: DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Quadratus Lumborum Block for Postoperative Pain Relief After Cesarean Delivery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: VAGABOND: a Mnemonic to Aid in the Memory Retention of the Canadian CT Head Rule
Status: COMPLETED
Conditions: Traumatic Brain Injury|Education
Interventions: BEHAVIORAL: Mnemonic|BEHAVIORAL: CCHR rule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of a Bundle of Interventions on the Outcomes of Patients With Intracranial Devices (ICP Monitor e EVD)
Status: NOT_YET_RECRUITING
Conditions: Central Nervous System Infections
Interventions: BEHAVIORAL: Health care practices and routines
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Vitrase as an Adjuvant to Increase Absorption and Dispersion of Other Injected Anesthetics
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Vitrase (ovine hyaluronidase) Lyophilized
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Volumetric Changes of Labial Soft Tissue Contour Following Different Approaches With Immediate Implant Placement
Status: COMPLETED
Conditions: Dental Implant Placement
Interventions: PROCEDURE: Connective tissue graft and customized healing abutment|PROCEDURE: Dual zone concept and customized healing abutment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Clinician Communication Skills (ICCS)
Status: COMPLETED
Conditions: Advanced Cancer|Chronic Obstructive Pulmonary Disease (COPD)|Restrictive Lung Disease|Congestive Heart Failure|End Stage Liver Disease
Interventions: BEHAVIORAL: Training Program Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ONC201 Plus Weekly Paclitaxel in Patients With Platinum Refractory or Resistant Ovarian Cancer
Status: RECRUITING
Conditions: Malignant Ovarian Epithelial Tumor|Platinum-Resistant Fallopian Tube Carcinoma|Platinum-Resistant Ovarian Carcinoma|Platinum-Resistant Primary Peritoneal Carcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Refractory Fallopian Tube Carcinoma|Refractory Ovarian Carcinoma|Refractory Primary Peritoneal Carcinoma
Interventions: DRUG: Akt/ERK Inhibitor ONC201|DRUG: Paclitaxel|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Verification of Shear Wave Elastography for DEtection of Prostate Cancer
Status: UNKNOWN
Conditions: Prostatic Neoplasms
Interventions: DEVICE: Shear Wave Elastography of prostate|DEVICE: Conventional Prostate Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Sural Nerve With Ultrasonography and Electromyography in Patients With Fibromyalgia
Status: UNKNOWN
Conditions: Fibromyalgia
Interventions: OTHER: Electromyographic measurement:|OTHER: Ultrasonographic measurement:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Safety And Efficacy Study Of Orally Administered Epeleuton In Patients With NAFLD
Status: COMPLETED
Conditions: Non Alcoholic Fatty Liver Disease
Interventions: OTHER: Placebo capsules|DRUG: Epeleuton
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Dose Study of the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of HSD-016
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: HSD-016|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Infection: Exploration of Respiratory Control Center Abnormalities
Status: COMPLETED
Conditions: Covid19|Neurological Complication
Interventions: OTHER: hypoxia : 14.3 and 12.7% FIO2, hypercapnia 7% CO2, inspiratory mechanical constraint
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lubiprostone and Mucus Secretion in Patients With Chronic Constipation
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: lubiprostone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: S-1 and Cisplatin (3 Weekly) Versus S-1 and Oxaliplatin Combination Chemotherapy for Advanced Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: S-1|DRUG: Cisplatin|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HIV/STI Prevention for Drug-Involved Couples
Status: COMPLETED
Conditions: Sexually Transmitted Infections
Interventions: BEHAVIORAL: Couple HIV/STI prevention intervention|BEHAVIORAL: Couple-based HIV/STI prevention|BEHAVIORAL: Individual HIV/STI prevention|BEHAVIORAL: Couple Wellness Promotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Total Versus Partial Arytenoidectomy in Bilateral Vocal Fold Paralysis
Status: COMPLETED
Conditions: Airway Obstruction|Vocal Cord Paralysis
Interventions: PROCEDURE: Total arytenoidectomy|PROCEDURE: Partial arytenoidectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Shaping Actions and Responses to Emotions
Status: COMPLETED
Conditions: Depression in Adolescence|Adverse Childhood Experiences
Interventions: BEHAVIORAL: Behavioral Activation (BA) Therapy|BEHAVIORAL: Problem Solving Therapy (PST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Quetiapine in Patients With Bipolar and Alcohol Abuse/Dependence
Status: COMPLETED
Conditions: Bipolar Disorder|Alcohol Abuse/Dependence
Interventions: DRUG: Quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Safety and Efficacy of A New Eye Drop Formulation With OPTIVE™ in Subjects With Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: Carboxymethylcellulose Based Eye Drop Formulation A|DRUG: Carboxymethylcellulose Based Preservative-Free Lubricant Eye Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial for Evaluation of Treatment With Multiple Infusions of Mononuclear Bone Marrow Cells in Patients With Chronic Liver Diseases
Status: UNKNOWN
Conditions: Chronic Hepatitis|Hepatic Cirrhosis
Interventions: BIOLOGICAL: Infusion of bone marrow mononuclear cells.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Investigate the Efficacy of a Toothpaste in Providing Relief From Dentinal Hypersensitivity
Status: COMPLETED
Conditions: Dentinal Sensitivity|Hypersensitivity
Interventions: DRUG: Test Toothpaste|DRUG: Negative Control Toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ICC-1132 - Candidate Vaccine Against P Falciparum Malaria
Status: COMPLETED
Conditions: Plasmodium Falciparum Malaria
Interventions: BIOLOGICAL: Malaria ICC-1132|BIOLOGICAL: Alhydrogel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, and Pharmacokinetics of UHE-103 Cream in Subjects With Tinea Cruris and/or Tinea Pedis
Status: COMPLETED
Conditions: Tinea Cruris|Tinea Pedis
Interventions: DRUG: UHE-103 Cream|DRUG: Naftin (naftifine hydrochloride) Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Dasatinib in the Treatment of Relapsed or Plateau Phase Multiple Myeloma
Status: COMPLETED
Conditions: Relapsed, Refractory or Plateau Phase Multiple Myeloma
Interventions: DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PDEI Following Mitral Valve Surgery in Patients With Pulmonary Hypertension
Status: COMPLETED
Conditions: Pulmonary Hypertension|Mitral Valve Surgery
Interventions: DRUG: Sildenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Skin Closures at Cesarean Delivery, Glue vs Subcuticular Sutures.
Status: COMPLETED
Conditions: Cesarean Wound; Dehiscence
Interventions: PROCEDURE: Glue (Dermabond®; Ethicon, Somerville, NJ).|PROCEDURE: Monocryl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise Intolerance and Skeletal Muscle Bioenergetics in Children With Deep Venous Thrombosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Deep Vein Thrombosis|Pulmonary Embolism
Interventions: OTHER: Magnetic Resonance Imaging|OTHER: Bicycle Ergometry|OTHER: Lab Panel|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: 15-day Sequential Therapy for Helicobacter Pylori Infection in Korea
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Clarithromycin|DRUG: metronidazole|DRUG: esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Pharmacodynamics of High Versus Standard Dose Rifampicin in Patients With Pulmonary Tuberculosis
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: Rifampicin in higher doses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Real-Time Functional Magnetic Resonance Imaging Neurofeedback to Improve Motor Function in Cerebellar Ataxia
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Neurofeedback treatment|BEHAVIORAL: At-home therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Yoga Poses and Breath Control Cardiovascular Changes in Hypertensive Post-Menopause Women
Status: COMPLETED
Conditions: Hypertension|Postmenopausal Symptoms
Interventions: OTHER: Yoga Poses|OTHER: Breath Control|OTHER: Stretching exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy of Bromfenac Ophthalmic Solution in Patients Undergoing Cataract Surgery
Status: COMPLETED
Conditions: Pain|Inflammation|Cataract
Interventions: DRUG: Bromfenac Ophthalmic Solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prasterone (Dehydroepiandrosterone) in Treating Postmenopausal Cancer Survivors With Vaginal Symptoms
Status: COMPLETED
Conditions: Breast Cancer|Gynecologic Cancer
Interventions: DRUG: prasterone|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: To Assess the Safety and Efficacy of R932348 Ophthalmic Solutions in Patients With Keratoconjunctivitis Sicca
Status: COMPLETED
Conditions: Keratoconjunctivitis Sicca
Interventions: DRUG: R348 Ophthalmic Solution, 0.2%|DRUG: R348 Ophthalmic Solution, 0.5%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Pertuzumab (Perjeta) Combined With Trastuzumab (Herceptin) and Standard Anthracycline-based Chemotherapy in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Locally Advanced, Inflammatory, or Early-stage Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: 5-Fluorouracil|DRUG: Cyclophosphamide|DRUG: Docetaxel|DRUG: Doxorubicin|DRUG: Epirubicin|DRUG: Paclitaxel|DRUG: Pertuzumab|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TRAnscranial Doppler CErebral Blood Flow and Cognitive IMPAIRment in Heart Failure
Status: RECRUITING
Conditions: Heart Failure|Cognitive Impairment|Carotid Stenosis
Interventions: DIAGNOSTIC_TEST: Echocardiography|DIAGNOSTIC_TEST: Doppler sonography|DIAGNOSTIC_TEST: Neuropsychological tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 1/2 Safety and Efficacy of PLX3397 in Adults With Relapsed or Refractory Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: PLX3397|DRUG: PLX3397
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modulation Of Airway Reactivity With Chronic Mechanical Strain
Status: COMPLETED
Conditions: Asthma
Interventions: DEVICE: Continuous Positive Airway Pressure (CPAP)|DEVICE: Continuous Positive Airway Pressure (CPAP) Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: IMCY-0098 Proof of ACtion in Type 1 Diabetes (IMPACT Study)
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: IMCY-0098 450 μg|DRUG: IMCY-0098 1350 μg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Hypertensive Cerebral Hemmorrhage Surgery
Status: NOT_YET_RECRUITING
Conditions: Hypertensive Intracerebral Hemorrhage
Interventions: PROCEDURE: The Neuroendoscopic, Trans-occipital Approach Evacuation of Acute Hypertensive Cerebral Hemmorrhage Combined Low-drainage Surgery|PROCEDURE: Endoscopic Evacuation of Acute Hypertensive Intracerebral Hemorrhage via Trans-frontal keyhole approach
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Biologic Effect of VG2025 in Patients With Solid Tumors
Status: RECRUITING
Conditions: Advanced Malignant Solid Tumor
Interventions: DRUG: Recombinant Human IL12/15 Dual-Regulated Oncolytic HSV-1 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transperineal Laser Ablation vs Transurethral Resection for Benign Prostatic Obstruction: A Randomized Clinical Trial
Status: COMPLETED
Conditions: Prostate Hyperplasia|Benign Prostatic Hyperplasia|Benign Prostatic Hypertrophy|Benign Prostatic Hypertrophy With Outflow Obstruction
Interventions: PROCEDURE: Trans-Perineal Laser Ablation of Prostate|PROCEDURE: Trans-Urethral Resection of Prostate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Carboplatin/Paclitaxel and Radiation in Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Bevacizumab|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Clinical Trial of the Combination of Acetylsalicylic Acid, Sodium Bicarbonate and Citric Acid, Produced by Geolab Pharmaceutical Industries Ltd., Compared to Acetylsalicylic Acid (Aspirin ® - Bayer) in Patients With Episodic Tension-type Headache.
Status: UNKNOWN
Conditions: Treatment of Episodic Tension Headache
Interventions: DRUG: Association: acetylsalicylic acid (500mg), sodium bicarbonate (1625) and citric acid (965)|DRUG: Aspirin - Bayer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Gravity on Dexterity, Hand-eye Coordination and Perception of Orientation and Distances
Status: UNKNOWN
Conditions: Healthy Volunteers
Interventions: OTHER: Parabolic flight|OTHER: movements of the upper limb, the gripping force, muscle activity and eye-cephalic subject movement measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Use of Platelet-rich Fibrin (PRF) Membranes in Lateral Alveolar Ridge Augmentation When Jaw Bone is Missing Before Dental Implant Installation. A Study Comparing an Autogenous Bone Block Graft Covered Either by a (PRF) Membrane (Test) or Bone Substitute and a Barrier Membrane (Control)
Status: COMPLETED
Conditions: Tooth-loss
Interventions: BIOLOGICAL: PRF is added in the test group.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Interventions for Caregivers of Patients With Acquired Brain Injury
Status: COMPLETED
Conditions: Acquired Brain Injury
Interventions: BEHAVIORAL: Building Better Caregivers|BEHAVIORAL: Problem Solving Training|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Lambdalina (Lidocaine Cream) Versus Placebo as an Anesthetic for Laser Hair Removal
Status: COMPLETED
Conditions: Local Anesthesia
Interventions: DRUG: Lambdalina® (Lidocaine 4% cream)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a New Behavioral Intervention on Alcohol Craving and Drinking
Status: RECRUITING
Conditions: Alcohol Drinking|Alcohol Drinking Related Problems
Interventions: BEHAVIORAL: Retrieval-extinction|BEHAVIORAL: Extinction|BEHAVIORAL: Retrieval
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Performance Evaluation of a Novel Non-invasive Glucometer, Calibrated Against Validated Interstitial Glucose References
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: Working Model 3.4NR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Transdiagnostic Sleep Health Intervention for Veterans With PTSD
Status: NOT_YET_RECRUITING
Conditions: Stress Disorders, Post-Traumatic|Sleep Initiation and Maintenance Disorders
Interventions: BEHAVIORAL: TranS-C for PTSD|BEHAVIORAL: Sleep Psychoeducation Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Between an Oral Nicotine Replacement Product and Nicorette® Gum
Status: COMPLETED
Conditions: Tobacco Dependence
Interventions: DRUG: Nicotine|DRUG: Nicotine Gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Apixaban in Adults With Congenital Heart Disease and Atrial Arrhythmias: the PROTECT-AR Study
Status: COMPLETED
Conditions: Congenital Heart Disease|Atrial Arrhythmia|Thromboembolism|Anticoagulants Causing Adverse Effects in Therapeutic Use
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ACT for Parents of Children With Neurodevelopmental Comorbidities
Status: RECRUITING
Conditions: Asthma in Children|Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy-based Asthma Management Training Program|BEHAVIORAL: Treatment-as-usual Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier (BBB) Disruption
Status: COMPLETED
Conditions: Glioma|Glioblastoma
Interventions: DEVICE: Focused ultrasound (FUS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT