pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study to Evaluate the Pharmacokinetics, Efficacy, Tolerability, and Safety of Subcutaneous Human Immunoglobulin (Newnorm) in Patients With Primary Immunodeficiency Diseases
Status: RECRUITING
Conditions: Primary Immune Deficiency
Interventions: BIOLOGICAL: Newnorm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Ultrasound-guided Genicular Nerve Radiofrequency Treatment
Status: NOT_YET_RECRUITING
Conditions: Gonarthrosis
Interventions: PROCEDURE: Genicular nerve pulse radiofrequency ablation 3|PROCEDURE: Genicular nerve pulse radiofrequency ablation 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Demonstrating the Diagnostic Power of an Electronic Nose: Study on Exhaled Air Samples
Status: TERMINATED
Conditions: Alzheimer Disease|Gastric Cancer|Urologic Cancer|Pneumological Cancer
Interventions: DEVICE: olfactory measuring device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Needle-free Jet Injection of Reduced-dose, Intradermal, Influenza Vaccine in >= 6 to < 24-month-old Children
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Vaxigrip® trivalent inactivated influenza vaccine|DEVICE: Intradermal spacer on Biojector® 2000 jet injector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Oxyflower® Gel as a Coadjuvant in Pericoronitis Treatment
Status: COMPLETED
Conditions: Pericoronitis
Interventions: OTHER: OxyFlower gel|OTHER: Chlorhexidine gel|OTHER: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CLG561 Proof-of-Concept Study as a Monotherapy and in Combination With LFG316 in Subjects With Geographic Atrophy (GA)
Status: COMPLETED
Conditions: Geographic Atrophy
Interventions: DRUG: CLG561|DRUG: LFG316|DRUG: Sham injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Implementation of Myofascial Techniques in Patients With Accessory Nerve Damage After Oncologic Treatment
Status: COMPLETED
Conditions: Accessory Nerve Injuries|Physical Therapy
Interventions: OTHER: Physical activity|OTHER: Physical therapy - myofascial techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Managing Temporomandibular Disorder (TMD) Symptoms
Status: COMPLETED
Conditions: Temporomandibular Joint Disorders
Interventions: BEHAVIORAL: Self Management|BEHAVIORAL: Targeted Self Management|DRUG: 20 mcg ethinyl estradiol and 100 mcg levonorgestrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of 'Supportive Parenting App' on Parental and Newborn Outcomes
Status: COMPLETED
Conditions: Postnatal Depression|Self Efficacy|Parent-Child Relations|Development, Child|Anxiety|Parenting Satisfaction
Interventions: OTHER: Supportive Parenting Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Continuous Subcutaneous Infusion Of ABBV-951 With Oral Carbidopa/Levodopa Tablets For Treatment Of Motor Fluctuations In Adult Participants With Advanced Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease (PD)
Interventions: DRUG: ABBV-951|DRUG: Placebo for Levodopa/Carbidopa (LD/CD)|DRUG: Levodopa/Carbidopa (LD/CD)|DRUG: Placebo for ABBV-951
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Test the Effectiveness of Controlled-Release OROS® Hydromorphone HCl Compared to Placebo in Patients With Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: DRUG: OROS hydromorphone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Smoking Reduction or Cessation With Nicotine Replacement Therapy
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Nicotine gum|DRUG: Placebo gum|DRUG: Nicotine inhaler|DRUG: Placebo inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Short AV Delay Permanent Pacing on Matrix Metalloproteinase Levels
Status: COMPLETED
Conditions: Aortic Aneurysm|Aortic Diseases|Pacemaker DDD
Interventions: DEVICE: adjustment of atrioventricular delay in DDD packers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Symptomatic Relief Effects of FLOMAX® in Patients With Signs and Symptoms of Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Prostatic Hyperplasia
Interventions: DRUG: Tamsulosin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenetic Testing of Saliva Samples From Patients With Five or More Exposure Days to rFVIIa Analogue in the Adept™2 Trial
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A With Inhibitors|Haemophilia B With Inhibitors
Interventions: OTHER: No treatment given
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Easytech Reversed Shoulder System Clinical Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteo Arthritis Shoulders|Avascular Necrosis of the Head of Humerus|Rotator Cuff Tear
Interventions: DEVICE: Easytech group
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Complementary Feeding of Canadian Infants
Status: COMPLETED
Conditions: Generation of Reactive Oxygen Species|Intestinal Inflammation
Interventions: OTHER: Iron fortified cereal|OTHER: Iron fortified cereal with fruit|OTHER: Meat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: CAR-T Cell Immunotherapy for HCC Targeting GPC3
Status: WITHDRAWN
Conditions: GPC3 Positive Hepatocellular Carcinoma|CAR-T Cell Immunotherapy
Interventions: BIOLOGICAL: CAR-T cell immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Berberine Hydrochloride on Blood Pressure and Vascular Endothelial Function in Patients With Hypertension
Status: UNKNOWN
Conditions: Hypertension|Endothelial Dysfunction|Blood Pressure
Interventions: DRUG: berberine hydrochloride|BEHAVIORAL: lifestyle intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Molecular Mechanisms Underlying Anabolic Resistance to Protein Intake During Muscle Disuse
Status: RECRUITING
Conditions: Atrophy, Disuse|Muscle Atrophy|Muscular Disorders, Atrophic|Disuse Atrophy|Disuse Atrophy Muscle of Thigh
Interventions: OTHER: Unilateral leg immobilization|OTHER: Contralateral active leg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessing an Oral Bruton Tyrosine Kinase Inhibitor, DZD9008 in Patients Who Have Non-Hodgkin B-cell Lymphoma (WU-KONG3)
Status: SUSPENDED
Conditions: Non-Hodgkin's B-cell Lymphoma
Interventions: DRUG: DZD9008
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Front-End Processing 3.0
Status: COMPLETED
Conditions: Hearing Loss|Hearing Loss, Sensorineural|Hearing Loss, Bilateral
Interventions: DEVICE: Audio processor SONNET|DEVICE: SONNET 2: Configuration 1|DEVICE: SONNET 2: Configuration 2|DEVICE: SONNET 2: Configuration 3|DEVICE: SONNET 2: Configuration 4|DEVICE: SONNET 2: OPUS 2 configuration|DEVICE: SONNET 2: SONNET configuration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Empagliflozin Addition in Modulating Metabolic Disturbances Associated With Olanzapine in Schizophrenia Patients
Status: NOT_YET_RECRUITING
Conditions: Sodium-glucose Transport Protein Two Inhibitor (SGLT2),Metabolic Deficits Caused by Antipsychotics
Interventions: DRUG: Empagliflozin|DRUG: olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Disease Progress in Chronic Hepatitis C Patients With Liver Fibrosis (Study P02570AM2)(COMPLETED)
Status: COMPLETED
Conditions: Chronic Hepatitis C|Liver Fibrosis
Interventions: BIOLOGICAL: peginterferon alfa-2b (SCH 54031)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The BCD-089 (aIL6R) in Patients With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Seropositive RA
Interventions: BIOLOGICAL: BCD-089, 162 mg, s/c, qw|BIOLOGICAL: BCD-089, 162 mg, s/c, q2w|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Probiotics on E. Coli Gastroenteritis
Status: COMPLETED
Conditions: Gastroenteritis|Bacterial Infection|Diarrhea
Interventions: DIETARY_SUPPLEMENT: probiotics|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Efficacy of Early Bunching of a FF-PCC in Patients With Severe Traumatic Hemorrhage
Status: NOT_YET_RECRUITING
Conditions: Trauma
Interventions: DRUG: 4 factor Prothrombin Complex Concentrates
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Microbiota and Bone Fragility:Study of the Relation Between Gut Microbiota and Bone Microarchitecture
Status: COMPLETED
Conditions: Bone Loss, Age-related
Interventions: RADIATION: bone densitometry|RADIATION: High resolution peripheral QCT|DIAGNOSTIC_TEST: Collection of biological samples|OTHER: questionnaires|OTHER: clinical tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study of Elenestinib (BLU-263) in Advanced Systemic Mastocytosis (AdvSM) and and Other KIT Altered Hematologic Malignancies
Status: RECRUITING
Conditions: Advanced Systemic Mastocytosis
Interventions: DRUG: BLU-263|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liver Spare the Nephron (STN) Study - A Study of CellCept (Mycophenolate Mofetil) and Sirolimus in Recipients of a Liver Transplant
Status: COMPLETED
Conditions: Liver Transplantation
Interventions: DRUG: mycophenolate mofetil [CellCept]|DRUG: Tacrolimus|DRUG: Cyclosporine|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PROphylactic Mesh to Prevent Incisional Hernias at the Former Stoma Site: the PROMISS-trial
Status: UNKNOWN
Conditions: Incisional Hernia
Interventions: DEVICE: Adhesix® monofilament polypropylene mesh (Bard Davol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Radiotherapy Omission in Low Risk Ductal in Situ Carcinoma Breast
Status: RECRUITING
Conditions: DCIS|Breast Cancer|Low Risk DCIS|Breast Conserving Surgery|Radiotherapy Omission
Interventions: RADIATION: Radiotherapy|OTHER: No Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Postextubation High-flow Therapy vs Noninvasive Ventilation in Obese or at High-risk Patients
Status: COMPLETED
Conditions: Extubation Failure
Interventions: DEVICE: Preventive Conditioned NIV Therapy after planned extubation|DEVICE: Preventive HFOT after planned extubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of the Opioid Modulation of the Effect of Alcohol on the Dopaminergic Reward System
Status: TERMINATED
Conditions: Alcohol Addiction
Interventions: DRUG: Placebo|DRUG: Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: CRESTOR Athero Imaging Head to Head IVUS Study
Status: COMPLETED
Conditions: Coronary Atherosclerosis
Interventions: DRUG: Rosuvastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of ANKASCIN 568-P Products on Decreasing HbA1c and Regulating Blood Glucose
Status: NOT_YET_RECRUITING
Conditions: High Blood Sugar|Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: ANKASCIN 568-P Red yeast rice capsules|DIETARY_SUPPLEMENT: Placebo Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GLPG2737 on Top of Orkambi in Subjects With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: GLPG2737|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Viscosupplementation for Early Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Synvisc One|OTHER: Routine management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Type 2 Diabetes Exemplar: A Remote Care Service for North West London
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DEVICE: Huma|BEHAVIORAL: Video group consultations|BEHAVIORAL: KNOW Diabetes|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hysteroscopic Evaluation of Fallopian Tubal Patency
Status: COMPLETED
Conditions: Infertility of Tubal Origin|Infertility, Female|Fallopian Tube Occlusion|Uterus Abnormal
Interventions: DIAGNOSTIC_TEST: Hysteroscopic Fallopian tube assessment using the "Parryscope" technique|DIAGNOSTIC_TEST: Hysteroscopic Fallopian tube assessment using the "Tubal flow" technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Influence of Femoral Head Size During Total Hip Arthroplasty on Gait
Status: COMPLETED
Conditions: Osteoarthritis, Hip|Hip Arthritis|Gait, Frontal
Interventions: PROCEDURE: Total hip replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Meperidine and Fentanyl on Pain Scale and QOL in Brachytherapy
Status: COMPLETED
Conditions: Pain|Quality of Life
Interventions: DRUG: Meperidine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of ARQ 197 in Combination With Gemcitabine in Adult Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: Treatment with ARQ 197 in combination with gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Combination of Mitiglinide and Metformin on Glycemic Control in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Mitiglinide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Structured Personalized Oxygen and Supportive Therapies for Dyspnea in Oncology
Status: RECRUITING
Conditions: Dyspnea
Interventions: BEHAVIORAL: SPOT-ON Early Start|BEHAVIORAL: SPOT-ON Delayed Start
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Study of REMAXA®, Enteric-coated Tablets and REMAXOL®, Solution for Infusions, in Intrahepatic Cholestasis
Status: RECRUITING
Conditions: Cholestasis, Intrahepatic
Interventions: DRUG: Remaxa, enteric-coated tablets|DRUG: Remaxol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Ocular Surface Disorders in Patients in Intensive Care Units, a Comparative Study of Three Preventive Approaches
Status: COMPLETED
Conditions: Corneal Diseases
Interventions: DEVICE: Aqueous Gel|DEVICE: Eyelid Occlusion Dressing|DEVICE: Artificial Tears
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Losmapimod in Treating Subjects With Facioscapulohumeral Muscular Dystrophy (FSHD) With Open-Label Extension (OLE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Facioscapulohumeral Muscular Dystrophy (FSHD)
Interventions: DRUG: Losmapimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stapler-less Burst Pressure in a Ex-vivo Human Gastric Tissue
Status: COMPLETED
Conditions: Obesity, Morbid|Suture, Complication|Suture Rupture
Interventions: OTHER: Stapler-less gastrectomy|OTHER: Suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Open-lable Extension Study on Safety and Efficacy of Neramexane to Treat Congenital and Acquired Nystagmus
Status: TERMINATED
Conditions: Nystagmus, Congenital|Nystagmus, Acquired|Multiple Sclerosis
Interventions: DRUG: Neramexane mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Myocardial Ischemic Preconditioning in Humans
Status: COMPLETED
Conditions: Coronary Artery Ischemia
Interventions: DEVICE: Blood pressure cuff|DEVICE: blood pressure cuff
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Glucagon Infusion in T1D Patients With Recurrent Severe Hypoglycemia: Effects on Counter-Regulatory Responses
Status: TERMINATED
Conditions: Hypoglycemia Unawareness|Diabetes Mellitus, Type 1
Interventions: DRUG: Glucagon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Inspiratory Muscle Training for Patients With Chronic Obstructive Pulmonary Disorder
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DEVICE: Threshold IMT Philips Respironics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dupilumab on Airway Hyper-responsiveness and Ventilation Heterogeneity in Patients With Asthma.
Status: COMPLETED
Conditions: Asthma
Interventions: BIOLOGICAL: Dupilumab/Dupixent|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electrical Stimulation Pain Therapy in Treating Chronic Pain and Numbness Caused By Chemotherapy in Patients With Cancer
Status: COMPLETED
Conditions: Cancer-related Problem/Condition|Neurotoxicity|Pain|Peripheral Neuropathy
Interventions: OTHER: electrical stimulation pain therapy|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacodynamic and Pharmacokinetic Dose Ranging Study of Tiotropium Bromide Administered Via Respimat Device in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium 0.625 mcg/puff|DRUG: Tiotropium 1.25 mcg/puff|DRUG: Tiotropium 2.5 mcg/puff|DRUG: Tiotropium 5 mcg/puff|DRUG: Placebo solution|DRUG: Tiotropium-18 lactose powder|DRUG: Placebo lactose powder|DRUG: Tiotropium 10 mcg/puff|DEVICE: Respimat|DEVICE: Handihaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Immunotherapy Combined With Chemotherapy in Patients With Locally Advanced ESCC
Status: COMPLETED
Conditions: Esophagus Cancer
Interventions: DRUG: Tislelizumab|DRUG: Paclitaxel-albumin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Deprivation's Regulation of Immune System Function and Behavior
Status: UNKNOWN
Conditions: Sleep Deprivation|Sleep
Interventions: BEHAVIORAL: Neuroeconomics task|BEHAVIORAL: Portion Size Task|PROCEDURE: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Spices, Inflammation and Vascular Response in Humans
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Italian Herb meal|OTHER: Cinnamon Meal|OTHER: Pumpkin Spice meal|OTHER: Placebo meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Study Evaluating Single Dose Of ILV-095 In Psoriasis Subjects
Status: TERMINATED
Conditions: Plaque Psoriasis
Interventions: DRUG: ILV-095 300 mg in a 4 to 1 ratio|DRUG: ILV-095 300 mg in a 4 to 1 ratio
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Periop Biochemical Stress Factors in Craniotomy Neurosurgical Procedure With Respect to Preop Hypertension
Status: COMPLETED
Conditions: Perioperative Hypertension
Interventions: DRUG: atenolol|DRUG: lisinopril|OTHER: glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Circulating Tumor DNA (ctDNA) in Locally Advanced Esophageal and Gastroesophageal (GE) Junction Adenocarcinoma
Status: RECRUITING
Conditions: Adenocarcinoma Esophagus
Interventions: DIAGNOSTIC_TEST: Circulating tumor DNA(ctDNA) level measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 1b Study to Investigate Safety and Tolerability of ARGX-119 in Adult Participants With DOK7-Congenital Myasthenic Syndromes (CMS)
Status: NOT_YET_RECRUITING
Conditions: Congenital Myasthenic Syndrome
Interventions: BIOLOGICAL: ARGX-119|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anthropometry in Gastroesophageal Reflux Disease and Esophageal Injury
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease (GERD)
Interventions: OTHER: Anthropometric measurements|PROCEDURE: Tissue samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety Study of NeuroStar TMS Therapy in Patients With Major Depressive Disorder With Postpartum Onset
Status: TERMINATED
Conditions: Depression, Postpartum
Interventions: DEVICE: NeuroStar Transcranial Magnetic Stimulation (TMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ambu AuraOnce Versus Ambu AuraGain LM in Children
Status: UNKNOWN
Conditions: Airway Management
Interventions: DEVICE: Ambu AuraOnce|DEVICE: Ambu AuraGain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Precision Cell Immunotherapy Combined With TACE in Advanced Liver Cancer
Status: UNKNOWN
Conditions: Precision Cell Immunotherapy|Transcatheter Arterial Chemoembolization|Advanced Liver Cancer
Interventions: PROCEDURE: TACE|BIOLOGICAL: Precision Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigation of the Dose-dependent Vascualr Effects of (-)-Epicatechin in Healthy Men
Status: COMPLETED
Conditions: Vasodilation
Interventions: DIETARY_SUPPLEMENT: Water|DIETARY_SUPPLEMENT: Epicatechin 0.1 mg/kg|DIETARY_SUPPLEMENT: Epicatechin 0.5 mg/kg|DIETARY_SUPPLEMENT: Epicatechin 1.0 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comprehensive Exercise Training Program During Hospitalization for an Acute CF Exacerbation
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: BEHAVIORAL: Aerobic exercise|BEHAVIORAL: Resistance exercise|BEHAVIORAL: Flexibility and postural exercise|BEHAVIORAL: Balance exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Exercise on Gait and Balance in Peripheral Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathies|Peripheral Nerve Diseases|Peripheral Nervous System Diseases
Interventions: BEHAVIORAL: Tai Chi|BEHAVIORAL: Functional Balance|BEHAVIORAL: Education Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of The Techniques in Correcting Large-Angle Exotropia
Status: NOT_YET_RECRUITING
Conditions: Exotropia|Evaluation of Surgical Techniques in Correcting Exotropia
Interventions: PROCEDURE: Evaluation of The Techniques of Lateral Rectus Muscle Combined Recession with Hang Back and Combined Recession with Z-Tenotomy in Correcting Large-Angle Exotropia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficacy and Safety Between Methylene Blue-mediated Photodynamic Therapy and 5% Amorolfine Nail Lacquer for Toenail Onychomycosis Treatment
Status: UNKNOWN
Conditions: Onychomycosis of Toenail
Interventions: PROCEDURE: Methylene blue-mediated photodynamic therapy|DRUG: Amorolfine 5% Nail Lacquer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of Carfilzomib in Patients With Previously-Treated Systemic Light Chain Amyloidosis
Status: COMPLETED
Conditions: Amyloidosis|Systemic Light Chain Amyloidosis
Interventions: DRUG: Carfilzomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interdisciplinary Pressure Management & Mobility Program as an Alternative to Usual Care: A Pilot Study
Status: COMPLETED
Conditions: Pressure Ulcer
Interventions: OTHER: Usual care|OTHER: Pressure management and Mobility program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effects of Intake of Two Cod Residual Meals on Glucose Regulation in Overweight and Obese Adults
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: DIETARY_SUPPLEMENT: Cod protein from presscake|DIETARY_SUPPLEMENT: Cod protein from presscake + stickwater|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Direct Pulp Capping Compared to Partial Pulpotomy in Carious Pulp Exposures
Status: ACTIVE_NOT_RECRUITING
Conditions: Deep Caries
Interventions: PROCEDURE: Direct pulp capping and partial pulpotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: In Vitro Study of Platelets Collected on Trima Accel System and Stored in InterSol Solution
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DEVICE: Platelets stored in InterSol|DEVICE: Platelets stored in Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cardiopulmonary Exercise Testing as an Outcome Predictor in Coronary Artery Bypass Surgery
Status: COMPLETED
Conditions: Coronary Artery Disease|Surgery--Complications
Interventions: DIAGNOSTIC_TEST: Cardiopulmonary Exercise Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prazosin for Agitation in Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease|Disruptive Behavior
Interventions: DRUG: Prazosin|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Genetic Polymorphisms on Dental Implant Loss
Status: COMPLETED
Conditions: Patients Treated by Means of 1 or More Dental Implants
Interventions: OTHER: anamnesis|PROCEDURE: oral examination|PROCEDURE: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial on the Effect of E-cigarette Advertising on Cigarette Perceptions in Adolescents
Status: COMPLETED
Conditions: Attentional Bias|Smoking Cues|Positive Perceptions About Cigarette Smoking|Social Norms|Smoking Susceptibility
Interventions: BEHAVIORAL: E-cigarette ad exposure|OTHER: non e-cigarette TV commercials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Triple vs. Dual Adjuvant Therapy Following Liver Resection for HCC.
Status: RECRUITING
Conditions: HCC
Interventions: DRUG: HAIC plus PD-1 inhibitors plus lenvatinib|DRUG: PD-1 inhibitors plus lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Evaluation of PL2200 Versus Enteric-Coated Aspirin in Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: PL2200 Aspirin Capsules|DRUG: Enteric-coated aspirin caplets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Safety and Immunogenicity of a Single Dose of a Quadrivalent Meningococcal (MenACYW) Conjugate Vaccine in Older Adults Who Received a Primary Vaccination (3 or More Years Earlier) in Study MET49
Status: COMPLETED
Conditions: Meningococcal Infection (Healthy Volunteers)
Interventions: BIOLOGICAL: Meningococcal Polysaccharide (serogroups A, C, Y, and W) Tetanus Toxoid Conjugate Vaccine|OTHER: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Central China Rosai-Dorfman Disease Registry
Status: UNKNOWN
Conditions: Rosai-Dorfman Disease|Langerhans Cell Histiocytosis
Interventions: DRUG: Mycophenolate mofetil combined with oral prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: Mediators in Nasal Hyperreactivity in Allergic Rhinitis and Chronic Rhinosinusitis
Status: UNKNOWN
Conditions: Hyperactivity|Allergic Rhinitis Due to House Dust Mite|Chronic Rhinosinusitis With Nasal Polyps
Interventions: DIAGNOSTIC_TEST: Cold, dry air
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of UCART19 in Pediatric Patients With Relapsed/Refractory B Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Refractory B-cell Acute Lymphoblastic Leukemia|Relapsed B-cell Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: UCART19
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of XT-150 in Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: BIOLOGICAL: XT-150|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dermacyd PH_DESILSTY_FL (Lactic Acid) - Photo Evaluation - Stay on Floral
Status: COMPLETED
Conditions: Hygiene
Interventions: DRUG: LACTIC ACID(ND)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dosing Study of Intravitreal Bevacizumab for Retinopathy of Prematurity
Status: COMPLETED
Conditions: Retinopathy of Prematurity
Interventions: DRUG: Intravitreal Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Constraint-Induced Therapy and Occupation-Based Intervention for Optimal Stroke Recovery
Status: COMPLETED
Conditions: Stroke|Cerebrovascular Accident
Interventions: BEHAVIORAL: Occupation-based practice (OBP)|BEHAVIORAL: Modified-constraint induced therapy (m-CIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Absorption, Distribution, Metabolism and Excretion (ADME) of [14C]-Pitolisant in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Pitolisant|RADIATION: [14C]-Pitolisant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Research Study to Look at Side Effects During Regular Injection With Factor VIII Medicine Named Turoctocog Alfa for a 8 Weeks Period
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A
Interventions: DRUG: turoctocog alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability Study of ZP-025 Vaginal Gel for the Treatment of Vaginal Dryness
Status: COMPLETED
Conditions: Vaginal Dryness
Interventions: DEVICE: Vaginal gel, Medical Device Class 2A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Intravenous Vedolizumab Administered Every 4 Weeks in Japanese Participants With Moderate to Severe Ulcerative Colitis or Crohn's Disease
Status: RECRUITING
Conditions: Ulcerative Colitis|Crohn's Disease
Interventions: DRUG: Vedolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Receiving Erythropoietic Agents
Status: COMPLETED
Conditions: Anemia, Iron-Deficiency|Kidney Failure, Chronic
Interventions: DRUG: Sodium Ferric Gluconate complex in sucrose|DRUG: Ferrous sulfate tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Antimicrobial Therapy on the Serum Level of P-cresol in Peritoneal Dialysis Patients
Status: TERMINATED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Flucloxacillin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Bronchial Blocker in Minimally Invasive Cardiac Surgery
Status: UNKNOWN
Conditions: Minimally Invasive Cardiac Surgery
Interventions: DEVICE: bronchial blocker for BB group|DEVICE: double lumen tube for DLT group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Renal Blood Flow Measurement With Positron Emission Tomography (PET)
Status: COMPLETED
Conditions: Renal Failure|Renal Artery Stenosis
Interventions: DRUG: 62Cu-ethylglyoxal bis(thiosemicarbazone)|DRUG: 15O-water|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Localization of Parathyroid Adenoma by Fluorocholine PET/MRI (Positron Emission Tomography -MRI)
Status: UNKNOWN
Conditions: Primary Hyperthyroidism
Interventions: DEVICE: PET-MR|DEVICE: PET-CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of Types of Fruits and Vegetables on Vascular Function
Status: COMPLETED
Conditions: Blood Pressure|Vascular Stiffness|Cardiovascular Risk Factor
Interventions: OTHER: LFV|OTHER: HFV|OTHER: CC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Drinking Fermented Milk on Immune Response
Status: COMPLETED
Conditions: Influenza
Interventions: DIETARY_SUPPLEMENT: Drinking fermented milk|DIETARY_SUPPLEMENT: placebo|BIOLOGICAL: Seasonal Influenza Vaccine (H1N1, H3N2, PhuB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Placement of Peripherally Inserted Central Venous Catheters (PICC) in Children Guided by Ultrasound
Status: COMPLETED
Conditions: Cardiovascular Infections|Peripheral Vascular Disease
Interventions: DEVICE: ultrasound|OTHER: traditional puncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Applying Cuff Air Leak Pressure as Intraoperative Cuff Pressure on Postoperative Complications
Status: WITHDRAWN
Conditions: Intubation Complication
Interventions: DEVICE: ventilation with critical intracuff pressure (Pcr)|DEVICE: ventilation with critical intracuff pressure (Pcr)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Early Rehab With VR for First-time Acute Stroke
Status: COMPLETED
Conditions: Stroke, Acute|Acute Ischemic Stroke
Interventions: BEHAVIORAL: virtual reality training|BEHAVIORAL: early rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: School-based Interventions for Test Anxiety in Adolescents
Status: NOT_YET_RECRUITING
Conditions: Anxiety
Interventions: BEHAVIORAL: Triggers for anxiety|BEHAVIORAL: Identifying and challenging negative thoughts|BEHAVIORAL: Relaxation|BEHAVIORAL: Goal Setting|BEHAVIORAL: Overcoming avoidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Descartes-25 in Relapsed/Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma|Relapse Multiple Myeloma
Interventions: DRUG: Descartes-25
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 24-week Open-label Extension Study Evaluating PXT00864 Effect in Mild AD Patients Further to PLEODIAL-I Completion
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: PXT00864
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant Suitability
Status: TERMINATED
Conditions: Emphysema|Chronic Obstructive Pulmonary Disease (COPD)|Cystic Fibrosis|Pulmonary Fibrosis|Bronchiectasis|Sarcoidosis|Pulmonary Hypertension|Alpha-1 Antitrypsin Deficiency
Interventions: DEVICE: Steen Solution™|OTHER: Conventional Lung Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Hypofractionated Radiation Therapy or Standard Radiation Therapy in Treating Patients With Ductal Breast Carcinoma In Situ or Early Invasive Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Ductal Breast Carcinoma In Situ|Invasive Breast Carcinoma|Stage I Breast Cancer AJCC v6|Stage IA Breast Cancer AJCC v7|Stage IB Breast Cancer AJCC v7|Stage II Breast Cancer AJCC v6 and v7|Stage IIA Breast Cancer AJCC v6 and v7|Stage IIB Breast Cancer AJCC v6 and v7
Interventions: RADIATION: External Beam Radiation Therapy|RADIATION: External Beam Radiation Therapy|RADIATION: Hypofractionated Radiation Therapy|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|RADIATION: Whole Breast Irradiation|RADIATION: Whole Breast Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Effects of Immediate Release Topiramate vs Extended Release Topiramate in Patients With Migraine
Status: WITHDRAWN
Conditions: Migraine|Headache
Interventions: DRUG: IR-TPM (Topamax)|DRUG: XR-TPM (Trokendi XR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Desflurane in Children With Laryngeal Mask Airway
Status: COMPLETED
Conditions: Desflurane Anesthesia
Interventions: DRUG: Sevoflurane/Desflurane|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Selinexor, Pomalidomide, and Dexamethasone With or Without Carfilzomib for the Treatment of Patients With Relapsed Refractory Multiple Myeloma, The SCOPE Trial
Status: RECRUITING
Conditions: Recurrent Multiple Myeloma|Refractory Multiple Myeloma
Interventions: DRUG: Carfilzomib|DRUG: Dexamethasone|DRUG: Pomalidomide|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|DRUG: Selinexor|PROCEDURE: X-Ray Imaging|PROCEDURE: Computed Tomography|PROCEDURE: Positron Emission Tomography|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MGuard Stent in ST-elevation Myocardial Infarction
Status: COMPLETED
Conditions: ST-elevation Myocardial Infarction|Thrombus|Stents
Interventions: DEVICE: MGuard net protective coronary stent|DEVICE: Bare-metal stent and manual thrombectomy device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BACE Trial Substudy 1 - PROactive Substudy
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Azithromycin|DEVICE: Dynaport®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SYNergy Stent® System Implantation With Mandatory Intra-VascularUltra-Sound Guidance and Dual Anti-Platelet Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease|Atherosclerosis|Stent Placement
Interventions: DRUG: Dual Antiplatelet (DAPT) Therapy|DEVICE: The Synergy® stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microbial, Immune, and Metabolic Perturbations by Antibiotics (MIME Study)
Status: RECRUITING
Conditions: Normal Physiology|Healthy
Interventions: DRUG: Amoxicillin|DRUG: Azithromycin|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE