pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Phase II Trial of Perifosine Following Tyrosine Kinase Inhibitor (TKI) - Failure in Patients With Renal Cancer
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Perifosine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET/MRI in Endometrial Cancer
Status: WITHDRAWN
Conditions: Cytoreductive Surgery|Grade 3 Endometrial Endometrioid Adenocarcinoma|High Grade Serous Carcinoma|Endometrial Undifferentiated Carcinoma|Endometrial Mixed Cell Adenocarcinoma
Interventions: COMBINATION_PRODUCT: PET/MRI with radiotracer ([18F]- fluorodeoxyglucose) and a gadolinium-based contrast agent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: taVNS in Mild to Moderate Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DEVICE: Active taVNS|DEVICE: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Dual Action Pneumatic Compression Device: Patient Ease of Use and Comfort
Status: COMPLETED
Conditions: Chronic Venous Insufficiency
Interventions: DEVICE: Dual Action Pneumatic Compression Device|DEVICE: Standard Compression Garments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: MeasurIng and Restoring Auditory Awareness for Cochlear Implant Listeners in noisE
Status: NOT_YET_RECRUITING
Conditions: Cochlear Hearing Loss
Interventions: BEHAVIORAL: Speech in noise comprehension test|BEHAVIORAL: Objective tests of perception of ambient sound cues in noise|BEHAVIORAL: Subjective tests of perception of ambient sound cues in noise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Natural History Study of Patients With Succinic Semialdehyde Dehydrogenase (SSADH) Deficiency
Status: ACTIVE_NOT_RECRUITING
Conditions: Succinic Semialdehyde Dehydrogenase Deficiency
Interventions: DEVICE: Transcranial magnetic stimulation (TMS)|DEVICE: Magnetic resonance imaging (MRI)|DEVICE: Electroencephalogram (EEG)|PROCEDURE: Bio-specimen Collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rituximab+Standard CHOP vs Rituximab+Bi-weekly CHOP for Untreated Stage III/IV Low-grade B-cell Lymphoma (JCOG0203)
Status: COMPLETED
Conditions: Lymphoma, B-Cell
Interventions: DRUG: Rituximab + Standard CHOP|DRUG: Rituximab + Bi-weekly CHOP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 7-VINCut Antibiotic Stewardship Intervention to Decrease Duration of Antibiotic Treatment and Carbapenem Use in Surgery
Status: COMPLETED
Conditions: Medication Adherence|Antibiotic Resistance, Microbial|Medication Errors and Other Product Use Errors and Issues
Interventions: BEHAVIORAL: Antimicrobial stewardship in surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bleeding in Partial Upper Hemisternotomy Versus Full Sternotomy Aortic Valve Replacement
Status: COMPLETED
Conditions: Aortic Valve Stenosis|Heart Valve Diseases
Interventions: PROCEDURE: Minimally invasive aortic valve replacement|PROCEDURE: Full sternotomy aortic valve replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TMS Visual Modulation in Body Dysmorphic Disorder
Status: RECRUITING
Conditions: Body Dysmorphic Disorders
Interventions: DEVICE: intermittent theta burst stimulation|DEVICE: continuous theta burst stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Efficacy and Safety of Pomalidomide Capsules Combined With Low-Dose Dexamethasone in Subjects With Relapsed and Refractory Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma|Recurrent or Refractory
Interventions: DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Adrenaline in Periarticular Analgesic Injection on Postoperative Pain Control After Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: 0.6 mg 1:1000 epinephrine (0.6 ml)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Product S2G6T-1in Patients With Symptomatic Inflammatory Interdigital Tinea Pedis
Status: TERMINATED
Conditions: Tinea Pedis
Interventions: DRUG: S2G6T-1|DRUG: S2G6T-2|DRUG: S2G6T-3|DRUG: S2G6T-4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Scratch Off Prompt on Health Engagement
Status: COMPLETED
Conditions: Blood Pressure Check (Hypertension Screening)|Cholesterol Test (Lipid Disorder Screening)
Interventions: BEHAVIORAL: Scratchoff Prompt: Name of Test|BEHAVIORAL: Scratchoff Prompt: Call to Action|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effects of Systemic or Adjunct Tramadol Addition to Lidocaine Used for IVRA in Patients Undergoing Hand Surgery
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Lidocaine|DRUG: lidocaine+adjunct tramadol|DRUG: lidocaine+systemic tramadol|DRUG: Fentanyl|DRUG: Atropine|DRUG: Midazolam|DRUG: Diclofenac sodium|DRUG: Ephedrine|DRUG: Ondansetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of a Digital Application for GDM Management in Improving Patients' Compliance
Status: RECRUITING
Conditions: Gestational Diabetes|Pregnancy in Diabetic
Interventions: OTHER: Datos mobile health application|OTHER: Regular follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Pilot Study of Triple NtRTI/NsRTI Therapy in Antiretroviral Naive HIV-1 Infected Patients
Status: UNKNOWN
Conditions: HIV
Interventions: DRUG: Zidovudine (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Vitamin D Supplementation Prevent Type 2 Diabetes?
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Unravel MGUS (Monoclonal Gammopathy of Unknown Significance)
Status: UNKNOWN
Conditions: Monoclonal Gammopathy of Unknown Significance
Interventions: OTHER: Blood sample taken|OTHER: Answering a lifestyle questionnaire|OTHER: Follow-up phone call from researcher (two years after first visit)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase II Study to Assess the Efficacy and Safety of Olokizumab in Patients With Crohn's Disease
Status: WITHDRAWN
Conditions: Crohn's Disease
Interventions: DRUG: Olokizumab (OKZ)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exalenz Lab Mode System Compared to Biopsy for H.Pylori Detection
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DEVICE: Dual Mode BreathID Hp System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Minimalist Music and Birdsongs in the Anxiety of Nursing Professionals in Oncology
Status: RECRUITING
Conditions: Anxiety Disorders and Symptoms
Interventions: OTHER: Minimalist music group|OTHER: Minimalist music + birdsongs group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: VentrAssistTM LVAD for the Treatment of Advanced Heart Failure - Destination Therapy
Status: UNKNOWN
Conditions: End-stage Heart Failure|Cardiomyopathies
Interventions: DEVICE: VentrAssistTM Left Ventricular Assist Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of a New Intraocular Lens
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: TECNIS Symfony Extended Range of Vision IOL, Model ZXR00|DEVICE: TECNIS Monofocal IOL, Model ZCB00
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inflammatory Response With Different Lipid Emulsions In Parenteral Nutrition In Children After Bone Marrow Transplantation
Status: COMPLETED
Conditions: Bone Narrow Transplantation
Interventions: DIETARY_SUPPLEMENT: Formula with soybean oil, medium-chain triglycerides|DIETARY_SUPPLEMENT: Soybean oil formula commonly used in the hospital
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Yt90 Zevalin and Combination Chemotherapy (Z-CHOP)in Treating Patients With Stage II, Stage III, or Stage IV Diffuse Large B-cell Lymphoma
Status: TERMINATED
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: Yttrium 90 -labeled ibritumomab tiuxetan (Zevalin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Adalimumab When Added to Inadequate Standard Anti-rheumatic Therapy in Patients With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Replacement of Fresh Embryo Transfers (ETs) by Frozen Embryo Transfers (FETs) Using Vitrification
Status: UNKNOWN
Conditions: In Vitro Fertilization
Interventions: PROCEDURE: freezing embryos by vitrification|PROCEDURE: fresh embryo transfers|DRUG: buserelin|DRUG: recombinant FSH|DRUG: human chorionic gonadotropin (pregnyl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia
Status: RECRUITING
Conditions: Aphasia|Post-stroke
Interventions: OTHER: Anodal transcranial direct current stimulation (tDCS) combined with speech-language therapy (SLT, including naming therapy and communicative-pragmatic therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of 177Lu-DOTA-EB-FAPI in Patients With Metastatic Radioactive Iodine Refractory Thyroid Cancer
Status: RECRUITING
Conditions: Refractory Thyroid Gland Carcinoma|Refractory Thyroid Gland Papillary Carcinoma|Refractory Thyroid Gland Follicular Carcinoma|Refractory Thyroid Gland Hurthle Cell Carcinoma
Interventions: DRUG: 177Lu-DOTA-EB-FAPI 1 radionuclide therapy|DRUG: 177Lu-DOTA-EB-FAPI 2 radionuclide therapy|DRUG: 177Lu-DOTA-EB-FAPI 3 radionuclide therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of a Balanced 3rd Generation HES Solution (Tetraspan®) After Cardiac Surgery
Status: UNKNOWN
Conditions: Elective Cardiac Surgery
Interventions: DRUG: Balanced hydroxyethyl starch solution|DRUG: Ringer- albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development and Evaluation of Virtual Reality Experiences for Cognitive Stimulation at the Sociosanitary Center El Carme
Status: COMPLETED
Conditions: Cognitive Dysfunction|Mild Cognitive Impairment
Interventions: DEVICE: Virtual Reality Cognitive Stimulation Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Neurophysiological Correlates of the Link Between Perception and Action
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: OTHER: Sensorial stimulations|OTHER: Experimental protocols|BEHAVIORAL: Emotional protocols|OTHER: Protocol with a spatial dimension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 4 Study to Determine Dosing of Hectorol® Capsules When Converting From Zemplar® Injection
Status: COMPLETED
Conditions: Secondary Hyperparathyroidism
Interventions: DRUG: Hectorol (doxercalciferol capsules)|DRUG: Zemplar (paricalcitol injection)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Performance of [18F]-FES for Endometriosis Diagnosis
Status: TERMINATED
Conditions: Endometriosis
Interventions: OTHER: [18F]FES (16α-[18F]Fluoro-17β-estradiol)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neural Mechanisms of Monoaminergic Engagement in Late-life Depression Treatment Response (NEMO)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Escitalopram Pill|OTHER: Placebo|DRUG: Levomilnacipran Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) Response to Low Dose Clomiphene Citrate in Normally Menstruating Fertile Women
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Clomiphene Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tailored Internet-administrated Treatment of Panic Symptoms - A Randomised Controlled Trial
Status: UNKNOWN
Conditions: Anxiety Disorders|Depression
Interventions: BEHAVIORAL: Tailored Internet-administrated CBT-Treatment|BEHAVIORAL: Waitlist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CytID Analysis of Oral Lesions
Status: TERMINATED
Conditions: Oral Cavity Cancer|Oropharyngeal Cancer
Interventions: OTHER: Oral examination with incandescent light|OTHER: Oral examination with OralID|DIAGNOSTIC_TEST: Biopsy|DIAGNOSTIC_TEST: CytID|DIAGNOSTIC_TEST: hpvID
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: User Evaluation of the MiniMed 620G and 640G Insulin Pumps
Status: COMPLETED
Conditions: Type 1 Diabetes|Type 2 Diabetes
Interventions: DEVICE: Medtronic MiniMed 620G or 640G Insulin Pump
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy of Three Antibiotic Protocols for Aggressive Periodontitis Treatment
Status: UNKNOWN
Conditions: Aggressive Periodontitis
Interventions: DRUG: Scaling and Root Planing combined with moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mifepristone Versus Laminaria Insertion for Cervical Preparation Prior to Surgical Abortion at 14-16 Weeks
Status: COMPLETED
Conditions: Abortion
Interventions: DRUG: mifepristone 200 mg|DEVICE: osmotic dilator insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Dose Vitamin B1 to Reduce Abusive Alcohol Use
Status: COMPLETED
Conditions: Alcoholism
Interventions: DRUG: Benfotiamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MK-0431/ONO-5435 Phase III Clinical Trial-Rapid-acting Insulin Secretagogue Add-on Study in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: MK-0431/ONO-5435|DRUG: Placebo, MK-0431/ONO-5435
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of an E-learning Tool on Patient Satisfaction, Knowledge and Medication Adherence in Solid Organ Transplantation: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Solid Organ Transplantation
Interventions: OTHER: Transplant Medication Information Teaching Tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements Using the Eye Tracker and Retest Function of Spectralis® SD-OCT in Glaucomatous Eyes and Healthy Controls
Status: TERMINATED
Conditions: Glaucoma
Interventions: DEVICE: Spectralis® SD-OCT, Heidelberg Engineering GmbH, H
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Apatinib and Tegafur Gimeracil Oteracil in Locally Advanced Squamous Cell Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Apatinib Mesylate Tablets|DRUG: Tegafur Gimeracil Oteracil Potassium Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Performance of Toric Hydrogel Lenses Following A Refit With Toric Silicone Hydrogel Lenses for 1 Month
Status: COMPLETED
Conditions: Ametropia
Interventions: DEVICE: methafilcon A toric contact lenses|DEVICE: fanfilcon A toric contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study for the Treatment of Anemia in Patients With Non-myeloid Malignancies Receiving Multicycle Chemotherapy.
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Darbepoetin alfa and Epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Potential Benefit of the Combination of Metamizole and Ibuprofen After Third Lower Molar Extraction
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Metamizole and Ibuprofen|DRUG: Metamizole and Placebo|DRUG: Ibuprofen and Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pre- or Per-dialytic Physical Exercise : a Cardioprotective Role?
Status: UNKNOWN
Conditions: Chronic Kidney Diseases
Interventions: PROCEDURE: Dialysis without physical exercise|PROCEDURE: Dialysis with pre-dialytic physical exercise|PROCEDURE: Dialysis with per-dialytic physical exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Signal TrAnsduction Pathway Activity Analysis in OVarian cancER
Status: RECRUITING
Conditions: Recurrent Ovarian Cancer|Signal Transduction Pathway Deregulation|Therapy-Associated Cancer
Interventions: DRUG: Letrozole Oral Product|DRUG: Bicalutamide Oral Product|DRUG: Everolimus Oral Product|DRUG: Itraconazole Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TReatment for ImmUne Mediated PathopHysiology
Status: RECRUITING
Conditions: Acute Liver Failure|Fulminant Hepatic Failure|Hepatic Encephalopathy|Acute Liver Injury|Immune Dysregulation
Interventions: DRUG: High-dose methylprednisolone|DRUG: Equine anti-thymocyte globulin|DRUG: Prednisolone|DRUG: Placebo for prednisolone|DRUG: Placebo for infusions|DRUG: Diphenhydramine|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Monosialoganglioside(GM1) Preventing Neurotoxicity Induced by Cisplatin Contained Chemotherapy in NSCLC Patients
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Monosialoganglioside(GM1)|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 3D Printed Models for Mandibular Fracture Repair
Status: NOT_YET_RECRUITING
Conditions: Mandible Fracture|Maxillofacial Trauma
Interventions: DEVICE: 3D Printed Model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Improving Dental Care and Oral Health in Children With Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: AIR-P Dental Toolkit|BEHAVIORAL: Parent Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylaxis for COVID-19: Ivermectin in Close Contacts of COVID-19 Cases (IVERNEX-TUC)
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Ivermectin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Haptic and Highly Fidelity Simulator in Cardiopulmonary Resuscitation Training
Status: UNKNOWN
Conditions: Nursing Caries|Cardiopulmonary Resuscitation
Interventions: DEVICE: High Fidelity Simulator|DEVICE: Haptic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cardiopulmonary-bypass and Reno-protective Effect of Atorvastatin Trial
Status: COMPLETED
Conditions: Acute Kidney Dysfunction
Interventions: DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-Dose Chemotherapy Compared With Standard Chemotherapy in Treating Patients With Stage III or Stage IV Ovarian Epithelial Cancer That Has Been Removed During Surgery
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: melphalan|DRUG: paclitaxel|PROCEDURE: adjuvant therapy|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Virtual Navigation Intervention to Reduce Behavioral Health Admissions From Rural Emergency Departments
Status: COMPLETED
Conditions: Depression|Anxiety|Substance Use Disorders
Interventions: BEHAVIORAL: Behavioral Health - Virtual Patient Navigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Bioavailability of Liposomal and Traditional Formulation of Vitamin D3
Status: COMPLETED
Conditions: Bioavailability of Vitamin D
Interventions: DIETARY_SUPPLEMENT: Liposomal Vitamin D|DIETARY_SUPPLEMENT: Traditional Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: NBI-98854 Dose Titration Study for the Treatment of Tardive Dyskinesia
Status: COMPLETED
Conditions: Tardive Dyskinesia
Interventions: DRUG: NBI-98854|DRUG: NBI-98854|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of MicroPort's Transcatheter Aortic Valve and Delivery System for TAVI
Status: UNKNOWN
Conditions: Aortic Valve Disease|Aortic Valve Stenosis|Aortic Valve Calcification
Interventions: DEVICE: MicroPort's Transcatheter Aortic Valve and Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Performance of the LumiraDx Influenza A/B + RSV Test at POC Testing Sites
Status: RECRUITING
Conditions: Influenza, Human|Respiratory Syncytial Virus Infections
Interventions: DIAGNOSTIC_TEST: Swab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Detection of Chlorhexidine in Tracheal Secretions After Routine Oral Care With Chlorhexidine Gluconate
Status: COMPLETED
Conditions: Chlorhexidine|Intensive Care
Interventions: DEVICE: Endotracheal tubes not allowing SSD|DEVICE: Endotracheal tubes allowing SSD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Prepulse Inhibition (PPI) of Startle Reflex in Schizophrenia Patients Related to Type of Treatment and Illness Duration
Status: COMPLETED
Conditions: Inhibition (Psychology)|Schizophrenia|Medication Adherence
Interventions: DEVICE: PPI monitoring device protocol|OTHER: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reconstruction of the Anterolateral Ligament (ALL) With Revision Anterior Cruciate Ligament (ACL) Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Rupture of Anterior Cruciate Ligament|Anterolateral Ligament Reconstruction
Interventions: PROCEDURE: ALL reconstruction (Anterolateral ligament)|PROCEDURE: ACL revision (Anterior cruciate ligament )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effects of Family Clinic and Municipality
Status: ACTIVE_NOT_RECRUITING
Conditions: At-risk Pregnant Women
Interventions: BEHAVIORAL: FACAM|BEHAVIORAL: Care as Usual|BEHAVIORAL: COS-P
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PREFerred Neurostimulation MODdalities - PREFMOD Study
Status: UNKNOWN
Conditions: Chronic Low-back Pain
Interventions: OTHER: Implantable Neurostimulator System (Spectra WaveWriter™ Spinal Cord Stimulator System), (Boston Scientific Neuromodulation Corporation, Valencia, California (CA), USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glivec in Pediatric Chronic Myeloid Leukemia (CML)
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Imatinib mesylate 100 mg (Glivec)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Does a Home-based Exercise Programme Affect Physical Capacity and Quality of Life in Patients With Pulmonary Embolism?
Status: COMPLETED
Conditions: Pulmonary Embolism
Interventions: OTHER: 8-week home-based exercise programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Tracheotomy Versus Prolonged Endotracheal Intubation in Intensive Care Unit (ICU) Patients
Status: TERMINATED
Conditions: Respiratory Insufficiency
Interventions: PROCEDURE: early tracheotomy|PROCEDURE: prolonged endotracheal intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Angles of Knee and Hip Joints for Optimization of Neuromuscular Electrical Stimulation of the Quadriceps Femoris Muscle
Status: COMPLETED
Conditions: Electrical Stimulation
Interventions: OTHER: MVIC and NMES with hip at 85º and knee at 20º|OTHER: MVIC and NMES with hip at 85º and knee at 60º|OTHER: MVIC and NMES with hip at 0º and knee at 20º|OTHER: MVIC and NMES with hip at 0º and knee at 60º
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of GE-O System on Gait Impairments in Multiple Sclerosis Subjects
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: OTHER: GE-O SYSTEM|OTHER: Conventional training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Sedation and Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Coronary Artery Bypass Grafting
Interventions: DRUG: Dexmedetomidine|DRUG: propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing the Outcomes of a Behavioral Parent Training Intervention
Status: COMPLETED
Conditions: Disruptive Behavior Disorder|Parenting
Interventions: BEHAVIORAL: Fitbit activity tracker|BEHAVIORAL: Monetary rewards|BEHAVIORAL: BPT training sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Immediate Effect of Acupuncture on the Upper Trapezius Muscle in Patients With Nonspecific Neck Pain.
Status: COMPLETED
Conditions: Nonspecific Neck Pain
Interventions: DEVICE: Acupuncture|DEVICE: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Oxidative Phosphorylation Inhibitor IACS-010759 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: DRUG: Oxidative Phosphorylation Inhibitor IACS-010759|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Biological Activity of C2L-OCT-01 PR in Acromegalic Patients
Status: TERMINATED
Conditions: Acromegaly
Interventions: DRUG: C2L-OCT-01 PR, 10 or 20 mg|DRUG: C2L-OCT-01 PR, 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Betadine Pleurodesis Via Tunneled Pleural Catheters
Status: WITHDRAWN
Conditions: Pleural Effusion|Pleurodesis|Malignant Pleural Effusion|Pleural Effusion Due to Congestive Heart Failure|Pleural Effusion in Conditions Classified Elsewhere|Pleural Effusions, Chronic
Interventions: DRUG: Povidone-Iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Baduanjin on Shoulder Function in Maintenance Hemodialysis Patients
Status: COMPLETED
Conditions: Hemodialysis Complication|Shoulder Joint Disorder|CKD-MBD
Interventions: OTHER: Baduanjin exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep to Lower Elevated Blood Pressure
Status: COMPLETED
Conditions: Hypertension|Sleep Disorders|Insomnia|Cardiovascular Diseases
Interventions: BEHAVIORAL: Online Sleep Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of an Aural Rehabilitation Program in Hearing-impaired Older Adults
Status: UNKNOWN
Conditions: Older Adults|Hearing Impairment|Nursing
Interventions: BEHAVIORAL: Hear-Talk-Activity audiological program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: e-PAT Neuromod Evaluation of Personalized rTMS for Resistant Depression
Status: WITHDRAWN
Conditions: Depressive Disorder|Treatment-Resistant
Interventions: PROCEDURE: Functional magnetic resonance imaging used to individualize rTMS protocol using robotic coil positioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Protease Inhibitors and Combined Oral Contraceptive Pharmacokinetics and Pharmacodynamics
Status: TERMINATED
Conditions: Contraception|HIV
Interventions: DRUG: Levonorgestrel and Ethinyl Estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Health in Preschoolers: a Randomized Controlled Trial
Status: UNKNOWN
Conditions: Sleep Initiation and Maintenance Disorders
Interventions: BEHAVIORAL: SHIP (Sleep Health in Preschoolers)|BEHAVIORAL: SHIP Control Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Augmenting Cerebral Blood Flow to Preserve the Penumbra Trial
Status: UNKNOWN
Conditions: Ischemic Stroke
Interventions: DEVICE: SPG stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relmacabtagene Autoleucel as First-Line Therapy for High-Risk Large B-Cell Lymphoma
Status: RECRUITING
Conditions: B-cell Lymphoma
Interventions: BIOLOGICAL: Relmacabtagene Autoleucel|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide in Treating Patients With AIDS-Associated Kaposi's Sarcoma
Status: COMPLETED
Conditions: AIDS-Related Kaposi Sarcoma|Recurrent Kaposi Sarcoma
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Remimazolam Besylate Versus Propofol for Sedation in Critically Ill Patients With Deep Sedation
Status: UNKNOWN
Conditions: Critically Ill|Deep Sedation
Interventions: DRUG: Remimazolam Besylate|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Acute Myocardial Injury by Trimetazidine in Patients Hospitalized for COVID-19
Status: UNKNOWN
Conditions: Acute Respiratory Distress Syndrome|Covid19|Myocardial Injury
Interventions: DRUG: Trimetazidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Alcohol Use Disorders and Alcohol-Related Harms in Pacific Islander Young Adults
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use Disorder|Alcohol; Harmful Use
Interventions: BEHAVIORAL: SPEAR (Strategies for Pacific Empowerment and Alcohol Reduction)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Low Molecular Weight Heparin and/or Aspirin in Prevention of Habitual Abortion
Status: COMPLETED
Conditions: Habitual Abortion
Interventions: DRUG: Aspirin|DRUG: Klexane|DRUG: Klexane and ASA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Irreversible Electroporation (NanoKnife) for the Treatment of Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma|Interventional Imaging
Interventions: DEVICE: NanoKnife
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atacand Dose Ranging in Hypertensive Pediatric Subjects 1 Year to Less Than 6 Years of Age
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: candesartan cilexetil (Atacand)|DRUG: candesartan cilexetil (Atacand)|DRUG: candesartan cilexetil (Atacand)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SGLT2 Inhibition and Stimulation of Endogenous Glucose Production: Protocol 2
Status: COMPLETED
Conditions: Type II Diabetes Mellitus
Interventions: DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Safety and Efficacy of Tildacerfont in Females With Polycystic Ovary Syndrome and Elevated Adrenal Androgens
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Tildacerfont|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Abdominal Binder in Colonoscopies Performed by Trainees
Status: COMPLETED
Conditions: Performance of Colonoscopy|Tolerance of Colonoscopy
Interventions: DEVICE: Abdominal binder (Revive 3-in-1 Postpartum Recovery Support Belt)|DEVICE: Loose abdominal binder (Revive 3-in-1 Postpartum Recovery Support Belt)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Colorectal Cancer Metastatic
Status: COMPLETED
Conditions: Colorectal Cancer Metastatic
Interventions: DRUG: AFLIBERCEPT|DRUG: Irinotecan|DRUG: Fluorouracil|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Acute Mood and Cognitive Performance Effects of Beverages Containing Phenolics in Healthy Adults
Status: COMPLETED
Conditions: Cognitive Function
Interventions: OTHER: Phenolic Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: TR-701 FA vs. Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections.
Status: COMPLETED
Conditions: Skin and Subcutaneous Tissue Bacterial Infections
Interventions: DRUG: TR-701 FA|DRUG: Linezolid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "Adding DNA-test for Screening of HLA-DQ2 and DQ8 to Improve Early Diagnosis of Celiac Disease"
Status: ENROLLING_BY_INVITATION
Conditions: Celiac Disease in Children
Interventions: OTHER: DNA test for screening HLA-DQ2 and DQ8 from dried blood spots to early detect Celiac Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Duloxetine Versus Placebo for Osteoarthritis Knee Pain
Status: COMPLETED
Conditions: Osteoarthritis Knee Pain
Interventions: DRUG: Duloxetine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prostate Screening Study Using MRI in BRCA Carriers
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: PROCEDURE: MS3TMRI / TRUS Guided Biopsy|DEVICE: MS3TMRI / TRUS Guided Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dyadic Approach to Perinatal Depression in Primary Care: Maternal Infant and Dyadic Care
Status: RECRUITING
Conditions: Depression, Postpartum|Efficacy, Self|Anxiety
Interventions: BEHAVIORAL: Promoting First Relationships-Brief|BEHAVIORAL: Perinatal Collaborative Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EEG Changes in Pediatrics With Language Dysfunction Evaluation of Sleep EEG Changes in Paediatric Patients With Language Dysfunction: A Follow up Study. EEG Changes in Pediatrics With Language Dysfunction
Status: COMPLETED
Conditions: Language Disorders in Children
Interventions: DRUG: Methylprednisolone and or prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: New Breath Actuated MDI Symbicort Compared to Symbicort pMDI and Budesonide pMDI for 12 Weeks Twice a Day
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Symbicort|DRUG: Symbicort|DRUG: Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Protein Supplementation Intervention for Improving Muscle Mass and Physical Performance in Older People With Sarcopenia
Status: UNKNOWN
Conditions: Sarcopenia
Interventions: DIETARY_SUPPLEMENT: Protein supplementation|DIETARY_SUPPLEMENT: Placebo oat drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Naloxone Nasal Spray Compared With Naloxone Injection for Opioid Overdoses Outside the Hospital
Status: COMPLETED
Conditions: Overdose|Drug Abuse
Interventions: DRUG: Naloxone, intranasal|DRUG: placebo, intranasal|DRUG: Naloxone, intramuscular|DRUG: placebo, intramuscular
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metformin in Patients Initiating ADT as Prevention and Intervention of Metabolic Syndrome
Status: TERMINATED
Conditions: Prostate Cancer|Metabolic Syndrome
Interventions: DRUG: Metformin|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing Impression Techniques for Maxillary Complete Denture Retention
Status: NOT_YET_RECRUITING
Conditions: Denture Retention|Patient Satisfaction
Interventions: PROCEDURE: Single step PVS impression|PROCEDURE: Conventional two-step PVS impression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Defining Predictors of RT Response to Vedolizumab in IBD
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn Disease of Small Intestine
Interventions: DRUG: Vedolizumab 300 MG Injection [Entyvio]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Prevent Type I-II Myoma After TCRM Recurrence by Gonadotropin-releasing Hormone (GnRH )Analogues or Mifepristone
Status: NOT_YET_RECRUITING
Conditions: Submucous Leiomyoma of Uterus
Interventions: DRUG: Zoladex|DRUG: Mifepristone Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Anticoagulation for Aortic Bioprosthesis (ANTIPRO)
Status: COMPLETED
Conditions: Aortic Valve Stenosis|Aortic Valve Disease|Aortic Valve Insufficiency|Aortic Valve Regurgitation
Interventions: DRUG: Warfarin|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Research Study Investigating Study Medicine (NNC9204-1177) for Weight Management in People With Overweight or Obesity
Status: COMPLETED
Conditions: Metabolism and Nutrition Disorder|Obesity
Interventions: DRUG: NNC9204-1177 A 1.0 mg/mL|DRUG: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Single Dose Dutasteride in Healthy Subjects
Status: COMPLETED
Conditions: Alcohol Related Disorders|Alcoholism|Alcohol Abuse
Interventions: DRUG: Dutasteride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose:
Clinical trial: Effect of Lactobacillus Plantarum DSM 33464 on Blood Lead Levels in Young Women of Child-bearing Age
Status: COMPLETED
Conditions: Elevated Blood Lead Levels
Interventions: DIETARY_SUPPLEMENT: Lactobacillus plantarum DSM 33464, MegaMetalliQ|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE