pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Phase 3 Study of VX-445 Combination Therapy in Subjects With Cystic Fibrosis Heterozygous for the F508del Mutation and a Minimal Function Mutation (F/MF)
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: VX-445/TEZ/IVA|DRUG: IVA|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Observational Study in Differentiated Thyroid Cancer Which is Radioactive Iodine (RAI) Refractory to Assess the Use of Multikinase Inhibitors
Status: COMPLETED
Conditions: Thyroid Neoplasms
Interventions: DRUG: Sorafenib (Nexavar, BAY43-9006)|DRUG: Other Multikinase inhibitors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of the Flexibility of the Perineum in Primiparous Women Using the Medical Device Emagina During 90 Days of Their Pregnancy Compared to Those Having a Standard Pregnancy Follow-up
Status: NOT_YET_RECRUITING
Conditions: Pregnancy|Childbirth
Interventions: DEVICE: Training with the Emagina device at home until birth|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial to Evaluate Efficacy and Safety of JOINTSTEM in Patients With Degenerative Arthritis
Status: COMPLETED
Conditions: Degenerative Arthritis|Knee Osteoarthritis
Interventions: BIOLOGICAL: JOINTSTEM|DRUG: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Real-time fMRI Neurofeedback in Patients With MCI
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: OTHER: real-time fMRI based neurofeedback from the hippocampus|OTHER: real-time fMRI based neurofeedback from another brain area
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Iron & Alginate Study
Status: COMPLETED
Conditions: Iron Deficiency|Anaemia
Interventions: DIETARY_SUPPLEMENT: alginate beads containing ferrous gluconate|DIETARY_SUPPLEMENT: ferrous gluconate in a capsule|DIETARY_SUPPLEMENT: ferrous gluconate in a capsule in presence of calcium|DIETARY_SUPPLEMENT: alginate beads with ferrous gluconate in presence of calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: BreathID® Test: A Non-invasive Modality to Detect Pancreatic Exocrine Insufficiency
Status: COMPLETED
Conditions: Chronic Pancreatitis|Healthy Volunteers
Interventions: DRUG: benzoyl-L-tyrosyl-[1-13C]alanine (Bz-Tyr-Ala)|DRUG: benzoyl-L-tyrosyl-[1-13C]alanine (Bz-Tyr-Ala)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Prospective Randomized Trial of Moderate vs Deep Neuromuscular Blockade During Laparoscopic Ventral Hernia Repair
Status: UNKNOWN
Conditions: Hernia, Ventral|Neuromuscular Blockade|Pneumoperitoneum
Interventions: PROCEDURE: Patients will be randomized to moderate (TOF 1-2) or deep (post tetanic count 1-2) relaxation. Low pressure insufflation (start pressure set at 8 mm Hg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Accuracy of CAD/CAM Cutting Guides and Customized Titanium Plates for Virtual Planning Transfer in Bimaxillary Orthognathic Surgeries
Status: UNKNOWN
Conditions: Evaluation of the Accuracy of Transferring the Virtual Planning to the Surgery
Interventions: PROCEDURE: orthognathic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Paediatric, Open, Follow up Study With Modigraf Examining Safety and Efficacy in de Novo Allograft Recipients
Status: TERMINATED
Conditions: Heart Transplantation|Kidney Transplantation|Liver Transplantation
Interventions: DRUG: Tacrolimus granules|DRUG: Tacrolimus capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability of a Single Intravenous Infusion of BX-U001 in Refractory Rheumatoid Arthritis
Status: NOT_YET_RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: hUC-MSC suspension|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The FARAPULSE ADVENT PIVOTAL Trial PFA System vs SOC Ablation for Paroxysmal Atrial Fibrillation
Status: ACTIVE_NOT_RECRUITING
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: FARAPULSE Pulsed Field Ablation System|DEVICE: RadioFrequency and Cryoballoon Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: " Effect of Single-nucleotide Polymorphism of CD40 Gene rs1883832 C/T on the Risk of Immune Thrombocytopenic Purpura "
Status: NOT_YET_RECRUITING
Conditions: Immune Thrombocytopenic Purpura
Interventions: DIAGNOSTIC_TEST: Genotyping of rs1883832C/T related single-nucleotide polymorphism
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: RCT of Intensive, Brief, and Control Indigenous Cultural Safety Training Interventions for Health Care Providers
Status: COMPLETED
Conditions: Education
Interventions: OTHER: Big Canoe|OTHER: Little Canoe|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Repurposing Bromocriptine for Abeta Metabolism in Alzheimer's Disease
Status: COMPLETED
Conditions: Familial Alzheimer Disease (FAD)|PSEN1 Mutation
Interventions: DRUG: Bromocriptine|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pectoralis Major Pedicle Bone Graft For 4-Part Proximal Humerus Fractures
Status: COMPLETED
Conditions: Patients With Closed Neer Type 4 Proximal Humerus Fractures
Interventions: PROCEDURE: Pectoralis Major Pedicle Bone Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of Intravenous AVE0005 (VEGF Trap) in Advanced Ovarian Cancer Patients With Recurrent Symptomatic Malignant Ascites
Status: COMPLETED
Conditions: Ovarian Neoplasms|Ascites
Interventions: DRUG: aflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®)|DRUG: Placebo|DRUG: aflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Telemedicine Optimized Burn Intervention
Status: COMPLETED
Conditions: Burns|Pediatric ALL
Interventions: PROCEDURE: Face-to-face burn care|PROCEDURE: Telemedicine enhanced burn care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: An BE Study to Compare 10mg & 20mg of IMP4297 Capsules in Healthy Chinese Subjects Under Fasting Condition
Status: UNKNOWN
Conditions: Solid Tumor
Interventions: DRUG: IMP4297(20mg)|DRUG: IMP4297(10mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Health Subject
Status: UNKNOWN
Conditions: Autoimmune Diseases
Interventions: DRUG: SN1011|DRUG: SN1011 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sorafenib Tosylate and Hypoxia-Activated Prodrug TH-302 in Treating Patients With Advanced Kidney Cancer or Liver Cancer That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Kidney Cancer|Liver Cancer
Interventions: DRUG: hypoxia-activated prodrug TH-302|DRUG: sorafenib tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Furmonertinib Combination Therapy As Neoadjuvant Treatment in Resectable EGFR-Mutated NSCLC
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer (NSCLC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hop Compounds on the Immune System (VH)
Status: RECRUITING
Conditions: Inflammatory Response
Interventions: DIETARY_SUPPLEMENT: Xanthohumol|DIETARY_SUPPLEMENT: Iso-alpha-Acids|DIETARY_SUPPLEMENT: Xanthohumol + Iso-alpha-Acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immunonutrition to Reduce Toxicities in Non-Small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Non Small Cell Lung Cancer|NSCLC|Non-small Cell Lung Cancer|Non-small Cell Lung Cancer Stage IIIB|Non-small Cell Lung Cancer Stage ⅢA|NSCLC Stage IIIB|NSCLC, Stage IIIA
Interventions: DIETARY_SUPPLEMENT: Impact® Advanced Recovery|DIETARY_SUPPLEMENT: Boost® High Protein|RADIATION: Radiation Therapy|DRUG: Chemotherapy|OTHER: Quality of life (EORTC-QLQ-30)|OTHER: Evaluation of Cognitive Function (FACT-Cog, v. 3.0)|OTHER: Mindfulness Questionnaire (FFMQ)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 4-step ASCOT in POI Women to Promote Follicular Rescue
Status: COMPLETED
Conditions: Premature Ovarian Insufficiency
Interventions: DRUG: G-CSF treatment for Bone marrow derived stem cell Mobilization|PROCEDURE: Platelet Rich Plasma ovarian injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EGD-assisted Bowel Preparation for Colonoscopy
Status: COMPLETED
Conditions: Esophagoscopy Techniques|Colonoscopy
Interventions: PROCEDURE: EGD-assisted administration of colonoscopy prep|PROCEDURE: Control Group received standard prep by oral administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: VTX-2337 and Pegylated Liposomal Doxorubicin (PLD) in Patients With Recurrent or Persistent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Epithelial Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Cancer
Interventions: DRUG: pegylated liposomal doxorubicin (PLD)|DRUG: VTX-2337|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Anagrelide and Hydroxyurea in High-Risk Essential Thrombocythemia Patients
Status: COMPLETED
Conditions: Thrombocythemia, Hemorrhagic
Interventions: DRUG: Anagrelide|DRUG: Hydroxyurea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TMC207-TiDP13-C208: Anti-bacterial Activity, Safety, and Tolerability of TMC207 in Participants With Multi-drug Resistant Mycobacterium Tuberculosis (MDR-TB).
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: TMC207|DRUG: Placebo|DRUG: Background regimen (BR) for MDR-TB (multi-drug resistant tuberculosis)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drug Metabolizing Enzyme and Transporter Function in Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Deficiency, Vitamin D
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Trial Evaluating a Hyaluronic Acid Matrix in the Treatment of Chronic Non-healing Diabetic Foot Ulcers (DFUs)
Status: NOT_YET_RECRUITING
Conditions: Diabetic Foot
Interventions: DEVICE: Hēlaquis Matrix is a hyaluronic acid matrix (HaM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HD Melphalan and SCT in Patients With IGDD or LCDD
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: filgrastim|DRUG: melphalan|PROCEDURE: Stem Cell Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MG1-MAGEA3 With Ad-MAGEA3 and Pembrolizumab in Patients With Previously Treated Metastatic Melanoma or Cutaneous Squamous Cell Carcinoma
Status: WITHDRAWN
Conditions: Metastatic Melanoma|Squamous Cell Skin Carcinoma
Interventions: DRUG: Ad-MAGEA3|DRUG: MG1-MAGEA3|DRUG: Pembrolizumab|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Investigating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Subcutaneous NNC0143-0406 A 0.6 mmol/L in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: NNC0143-0406|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lymphocyte-Depleting Nonmyeloablative Preparative Chemotherapy Followed By Autologous Lymphocyte Infusion, Peptide Vaccine Plus Montanide ISA-51, and Interleukin-2 in Treating Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: NY-ESO-1 peptide vaccine|BIOLOGICAL: aldesleukin|BIOLOGICAL: filgrastim|BIOLOGICAL: incomplete Freund's adjuvant|BIOLOGICAL: therapeutic autologous lymphocytes|DRUG: cyclophosphamide|DRUG: fludarabine phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of MEDI4736, Tremelimumab, and MEDI4736 in Combination w/ Tremelimumab Squamous Cell Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Recurrent/Metastatic Squamous Cell Carcinoma of Head & Neck
Interventions: DRUG: MEDI4736|DRUG: Tremelimumab|DRUG: MEDI4736 + Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BHS5 - Testing the Effectiveness of the Exercise Plus Program
Status: COMPLETED
Conditions: Hip Fracture
Interventions: BEHAVIORAL: Exercise Trainer component of the Exercise Plus Program|BEHAVIORAL: Plus component (motivation) of the Exercise Plus Program|BEHAVIORAL: Exercise Plus Program (exercise + motivation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rectal and Oral Omeprazole Treatment of Reflux Disease in Infants.
Status: COMPLETED
Conditions: Gastroesophageal Reflux|Esophageal Atresia|Hernia, Diaphragmatic
Interventions: DRUG: Omeprazole rectally 1mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incremental Hemodialysis for Veterans in the First Year of Dialysis (IncHVets)
Status: RECRUITING
Conditions: Chronic Kidney Disease (CKD) Stage 5|Kidney Dysfunction Requiring Dialysis (KDRD)|Dialysis Dependency
Interventions: OTHER: Twice-weekly hemodialysis with incremental crossover to thrice-weekly schedule|OTHER: Thrice-Weekly Hemodialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Community Health Worker Based Intervention to Improve Palliative Care
Status: ENROLLING_BY_INVITATION
Conditions: Cancer|End Stage Cancer|Malignancy|Advanced Cancer
Interventions: OTHER: Community Health Worker (CHW) based palliative care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Know the Efficacy of Higher Doses of Pralidoxime in Patients of Organophpsphorus Poisoning.
Status: COMPLETED
Conditions: Acute Organophosphorus Pesticide Poisoning
Interventions: DRUG: Pralidoxime(drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study to Evaluate Brincidofovir for the Prevention of Adenovirus Disease
Status: COMPLETED
Conditions: Adenovirus Disease
Interventions: DRUG: Brincidofovir|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of the Cognitive Strategy During Trunk Muscle Endurance in Patients With Lumbar Hernia Surgery
Status: COMPLETED
Conditions: Low Back Pain|Disk Herniated Lumbar
Interventions: DIAGNOSTIC_TEST: Biering-Sorensen Test and Prone Plank Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy Study of Two Treatments in the Remission of Vasculitis
Status: COMPLETED
Conditions: Wegener Granulomatosis|Microscopic Polyangiitis
Interventions: DRUG: Rituximab|DRUG: Azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Pre-existing Adjacent Segment Degeneration on Long-term Effectiveness After Lumbar Fusion Surgery
Status: RECRUITING
Conditions: Degenerative Lumbar Spinal Stenosis|Degenerative Disc Disease|Degeneration Spine
Interventions: OTHER: Pre-existing degenerative factors at adjacent segment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Alfacalcidol to Respiratory Infection and Immune Response of Indonesian Elderly
Status: UNKNOWN
Conditions: Frail Elderly Syndrome|Elderly Infection
Interventions: DRUG: Alfacalcidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of FLACS With Combination of LenSx® and Centurion®
Status: COMPLETED
Conditions: Cataract
Interventions: PROCEDURE: FLACS|PROCEDURE: Manual conventional surgery|DEVICE: CENTURION® Vision System|DEVICE: LenSx®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AZD3470 as Monotherapy and in Combination With Anticancer Agents in Participants With Relapsed/Refractory Haematologic Malignancies.
Status: RECRUITING
Conditions: Lymphoma|Non-Hodgkin|Hodgkin Lymphoma
Interventions: DRUG: AZD3470
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Cardiac Benefit of Testosterone Replacement in Men With Low Testosterone Levels With Coronary Artery Disease After Successful Intervention of the Blockage or Narrowed Heart Artery
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: AndroGel 5 Grams|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Isatuximab in Combination With Chemotherapy in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia
Interventions: DRUG: Isatuximab|DRUG: Dexamethasone or equivalent|DRUG: Fludarabine|DRUG: Cytarabine|DRUG: Liposomal daunorubicin|DRUG: Daunorubicin (nonliposomal)|DRUG: Idarubicin|DRUG: Filgrastim or equivalent|DRUG: Mitoxantrone|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Pegaspargase (PEG) Asparaginase|DRUG: Cyclophosphamide|DRUG: Etoposide|DRUG: Methotrexate|DRUG: L - Asparginase|DRUG: Hydroxyurea|DRUG: L - Asparaginase (Erwinase)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Corticosteroid and Local Anesthetic Injections Patients With Concomitant Pes Anserine Bursitis
Status: COMPLETED
Conditions: Osteoarthritis Knees Both
Interventions: DRUG: Lidocaine injection|DRUG: Corticosteroid injection|OTHER: Conventional Physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Repetitive Transcranial Magnetic Stimulation Combined With Sensory Cueing on Unilateral Neglect in Subacute Patients With Right Hemispheric Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)|BEHAVIORAL: Sensory Cueing (SC)|BEHAVIORAL: Conventional Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of IV Ganaxolone as Adjuvant Therapy for Established Status Epilepticus (ESE)
Status: WITHDRAWN
Conditions: Status Epilepticus
Interventions: DRUG: IV Ganaxolone|DRUG: IV Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cutibacterium Acnes in Deep Tissues in Primary Spine and Shoulder Surgery
Status: UNKNOWN
Conditions: Rotator Cuff Tear Arthropathy|Spine Degeneration
Interventions: DRUG: Benzoyl peroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Suvorexant (MK-4305) for Reducing Incidence of Delirium in Japanese Participants at High Risk of Delirium (MK-4305-085)
Status: COMPLETED
Conditions: Delirium
Interventions: DRUG: Suvorexant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Exercise-snacks at Work: Impact on Cardiometabolic Parameters
Status: RECRUITING
Conditions: Sedentary Time|Overweight and Obesity|Work-Related Condition
Interventions: OTHER: Exercise-snacks program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: HAIC Using Oxaliplatin Plus Fluorouracil/Leucovorin for Patients With Locally Advanced HCC
Status: APPROVED_FOR_MARKETING
Conditions: Hepatocellular Carcinoma|Injury; Blood Vessel, Hepatic, Artery
Interventions: PROCEDURE: HAIC using oxaliplatin plus fluorouracil/leucovorin|DRUG: Oxaliplatin|DRUG: Fluorouracil|DRUG: Leucovorin
Study Type: EXPANDED_ACCESS
Clinical trial: Belotecan (CKD-602) in Recurrent or Progressive Carcinoma of Uterine Cervix
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: DRUG: Belotecan(CKD-602)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-Estrogens - A Potential Treatment for Bipolar Affective Disorder in Women?
Status: COMPLETED
Conditions: Bipolar Disorder|Mania|Schizoaffective Disorder
Interventions: DRUG: Tamoxifen|DRUG: Progesterone|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Feasibility of an Adapted Physical Activity Program During the Hospitalization Phase in Cancer Patients Undergoing Treatment
Status: NOT_YET_RECRUITING
Conditions: Cancer
Interventions: OTHER: adapted physical activity program (APA Program)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 5fluorouracil for Advanced Photoaging
Status: UNKNOWN
Conditions: Photoaging|Actinic Keratosis
Interventions: DRUG: 5-fluoruracil|PROCEDURE: 5-fluoruracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotic Treatment in Adult Obsessive-Compulsive Disorder
Status: TERMINATED
Conditions: Obsessive-Compulsive Disorder
Interventions: DIETARY_SUPPLEMENT: Probiotic Formula (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Different Methods of Support With Stopping Smoking (PORTSSS/Stop Together Trial)
Status: COMPLETED
Conditions: Tobacco Smoking
Interventions: BEHAVIORAL: Proactive telephone support|BEHAVIORAL: Reactive (standard) telephone support|DRUG: Offer of voucher for cost-free Nicotine Replacement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Human Anti-tumor Necrosis Factor (TNF) Monoclonal Antibody Adalimumab in Subjects With Active Ankylosing Spondylitis
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: BIOLOGICAL: adalimumab (D2E7)|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preimplantation Genetic Diagnosis (PGD) With Gonadotropin-releasing Hormone (GnRH) Agonist Versus Antagonist
Status: COMPLETED
Conditions: Reproductive Endocrinology|Fertility|Optimal Stimulation Protocol
Interventions: DRUG: GnRH agonist|DRUG: GnRH antagonist|DRUG: hP-hMG|DRUG: Human chorionic gonadotropin|DRUG: Progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fast-tracking ERCP Learning: Does Training on a Mechanical Simulator Improve Trainee's Clinical Performance?
Status: COMPLETED
Conditions: Cholangiopancreatography, Endoscopic Retrograde|Simulation Training
Interventions: OTHER: Simulation training in Boškoski-Costamagna ERCP Trainer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of the Bioavailability of Nasal Naloxone
Status: COMPLETED
Conditions: Drug Overdose
Interventions: DRUG: naloxone intranasal|DRUG: naloxone intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Insulin Lispro Biphasic 25 Compared to Humalog® Mix 25 in Type 2 Diabetes Mellitus Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Diabetes Mellitus
Interventions: DRUG: Humalog Mix25|DRUG: Insulin Lispro Biphasic 25
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Telemedicine Neurological Consult Program for Drug-Induced Movement Disorders Using the RE-AIM Framework
Status: ACTIVE_NOT_RECRUITING
Conditions: Drug-Induced Movement Disorder
Interventions: OTHER: Telemedicine Consult|OTHER: In-person Consult
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Steroid Withdrawal in Pediatric Kidney Transplant Recipients
Status: TERMINATED
Conditions: End-Stage Renal Disease
Interventions: DRUG: Basiliximab|DRUG: Cyclosporine|DRUG: Tacrolimus|DRUG: Sirolimus|DRUG: Methylprednisolone|DRUG: Prednisone|DRUG: Bactrim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Low Field Magnetic Stimulation for Treatment Resistant Depression
Status: COMPLETED
Conditions: Treatment Resistant Depression
Interventions: DEVICE: Active Low Field Magnetic Stimulation|DEVICE: Sham Low Field Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the ECG Effects Related to Pharmacokinetic Profile of Chloroquine and Piperaquine
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Chloroquine|DRUG: Dihydroartemisinin-piperaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Determining the Sustained Virologic Response of Declatasvir in Egyptian Patients With Hepatitis C Virus Genotype 4
Status: UNKNOWN
Conditions: Hepatitis C
Interventions: DRUG: Daclatasvir 60 MG Oral Tablet [Daklinza]|DRUG: Sofosbuvir 400 MG Oral Tablet [Sovaldi]|DRUG: Ribavirin Oral Product
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cardiovascular Risk Assessment in a Cohort of Italian Patients With Type 1 Diabetes Mellitus (CARDT1)
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1|Cardiovascular Diseases
Interventions: OTHER: Standard of care plus additional examinations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Strength and Constant Score Pre- and Post-Subacromial Injection for Full Thickness Rotator Cuff Tears
Status: WITHDRAWN
Conditions: Rotator Cuff|Subacromial Impingement Syndrome
Interventions: DRUG: Lidocaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Non-Inferiority
Status: COMPLETED
Conditions: Rheumatic Heart Disease
Interventions: DRUG: Rivaroxaban (20 mg)|DRUG: Vitamin K antagonists (VKA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intrauterine Levonorgestrel and Observation or Observation Alone in Preventing Atypical Endometrial Hyperplasia and Endometrial Cancer in Women With Hereditary Non-Polyposis Colorectal Cancer or Lynch Syndrome
Status: TERMINATED
Conditions: Endometrial Cancer|Hereditary Non-polyposis Colon Cancer (hmsh2, hmlh1, hpms1, hpms2)
Interventions: DEVICE: levonorgestrel-releasing intrauterine system|OTHER: questionnaire administration|PROCEDURE: observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bortezomib and Lenalidomide in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Recurrent Mantle Cell Lymphoma
Interventions: DRUG: Bortezomib|OTHER: Laboratory Biomarker Analysis|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atezolizumab + Pertuzumab + Trastuzumab In CNS Mets In BC
Status: ACTIVE_NOT_RECRUITING
Conditions: HER2-positive Metastatic Breast Cancer|Central Nervous System Metastases
Interventions: DRUG: ATEZOLIZUMAB|DRUG: PERTUZUMAB|DRUG: TRASTUZUMAB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Bone Quality and Quantity for Three Dimensional Bone Augmentation for Maxilla Using Patient Specific Titanium Meshes Loaded With Bone Marrow Aspirate Mixed With Xenograft Versus Xenograft Mixed With Autografts Only: a Randomized Clinical Trial
Status: UNKNOWN
Conditions: Atrophic Maxilla
Interventions: PROCEDURE: Three dimensional maxillary bone augmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: the Effect of Calcium Dobesilate on Non Dialysis Patients With CKD
Status: UNKNOWN
Conditions: Chronic Renal Failure
Interventions: DRUG: Calcium Dobesilate group|DRUG: Conventional Treatment group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Oxytocin on Cognitive and Reactive Fear
Status: UNKNOWN
Conditions: Oxytocin
Interventions: DRUG: Oxytocin nasal spray|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long-Term Immune Persistence of GSK Biologicals' Combined Hepatitis A & B Vaccine Injected According to a 0,6 Month Schedule
Status: COMPLETED
Conditions: Hepatitis B|Hepatitis A
Interventions: BIOLOGICAL: TWINRIX™ ADULT|BIOLOGICAL: Engerix TM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ranibizumab for Neovascularization in Sickle Cell Retinopathy
Status: WITHDRAWN
Conditions: Sickle Cell Anemia|Retinopathy
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hippocampal Response to Acute Oral Doses of CBD During an fMRI Memory Task
Status: ACTIVE_NOT_RECRUITING
Conditions: CBD
Interventions: DRUG: CBD|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Dynamic Taping in Symptomatic Rotator Cuff Tendinopathy
Status: COMPLETED
Conditions: Rotator Cuff Tendinosis
Interventions: OTHER: Dynamic taping|OTHER: Kinesio taping|OTHER: Physiotherapy and Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Vidiac Scores of Obese and Morbid Obese Patients Intubated by Videolaryngoscopy
Status: NOT_YET_RECRUITING
Conditions: Vidiac Score|Videolaryngoscopy|Obesity, Morbid
Interventions: DIAGNOSTIC_TEST: Vidiac Score
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Exercise and Manuel Therapy Methods on Pain, Posture, Daily Living in People With Cervical Pathologies
Status: COMPLETED
Conditions: Musculoskeletal Disorder of the Neck
Interventions: PROCEDURE: Muscle Energy Technic|PROCEDURE: Deep Friction Massage|PROCEDURE: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Head-to-head Comparison of Positron Nuclide Radio-labeled FAPI and 18F-FDG PET/CT in Patients With Malignant Tumors
Status: RECRUITING
Conditions: Renal Cell Carcinoma|Gastric Cancer|Hepatocellular Carcinoma|Signet Ring Cell Carcinoma|Mucinous Adenocarcinoma|Colorectal Cancer
Interventions: DIAGNOSTIC_TEST: FAPI PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Heat Activated Liposomal Doxorubicin and Radiofrequency Ablation in Treating Patients With Primary or Metastatic Liver Tumors
Status: COMPLETED
Conditions: Liver Cancer|Metastatic Cancer
Interventions: DRUG: lyso-thermosensitive liposomal doxorubicin|PROCEDURE: radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Tolerability of HPN-100 Compared to Sodium Phenylbutyrate in Children With Urea Cycle Disorders
Status: COMPLETED
Conditions: Urea Cycle Disorders
Interventions: DRUG: HPN-100|DRUG: NaPBA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double Blind, Efficacy Study of Escitalopram in ENT Cancer Patients Suffering From Emotional Distress
Status: COMPLETED
Conditions: ENT Cancer
Interventions: DRUG: Escitalopram|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Comparison of Efanesoctocog Alfa vs Other EHL-rFVIII Products in Participants With Severe Haemophilia A
Status: NOT_YET_RECRUITING
Conditions: Hemophilia A
Interventions: DRUG: Efanesoctocog alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Melatonin, Vitamins and Minerals Supplements for the Treatment of Covid-19 and Covid-like Illness
Status: COMPLETED
Conditions: Influenza -Like Illness
Interventions: DRUG: kelavit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Breakfast and Muscle Health in Children
Status: COMPLETED
Conditions: Body Weight Changes|Body Composition|Muscle Mass|Energy Expenditure|Nutrition
Interventions: OTHER: Carbohydrate|OTHER: Protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Open-label Study to Evaluate the Effect of MBP-80 on Bone Remodelling
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis
Interventions: DIETARY_SUPPLEMENT: 200 g yogurt with fortified calcium content and MBP 80 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Randomized Controlled Feasibility Study of Emotional Well-being of Adolescents Undergoing a Mindfulness Training During COVID-19
Status: COMPLETED
Conditions: Healthy
Interventions: BEHAVIORAL: Training for Awareness, Resilience, and Action (TARA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Quetiapine Fumarate Sustained Release (SEROQUEL SR) in the Treatment of Major Depressive Disorders
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Quetiapine fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A First-in-human, Single-ascending-dose Study of IBI3002 in Healthy Participants and Mild to Moderate Asthmatics
Status: RECRUITING
Conditions: Healthy Participants|Asthma
Interventions: DRUG: IBI3002|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Camrelizumab Plus Chemotherapy as Neoadjuvant Therapy in Participants With Triple Negative Breast Cancer (TNBC)
Status: NOT_YET_RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Camrelizumab|DRUG: Nab-Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Amphetamine-induced Sensitization on Dopamine Synthesis and Release
Status: UNKNOWN
Conditions: Schizophrenia|Psychosis|Sensitisation
Interventions: DRUG: Dextroamphetamine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Parent-Child Dieting Plans Incorporating Medifast Meal Replacements for Weight Loss
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Medifast FIT! for Kids|BEHAVIORAL: standard recommendations for dietary intake in children|BEHAVIORAL: both diet plans with and without a parent dieting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Tolerability of Debio 1562 in Combination With Rituximab in Participants With Relapsed and/or Refractory DLBCL and Other Forms of NHL
Status: COMPLETED
Conditions: Diffuse Large B-Cell Lymphoma|B-cell Non-Hodgkin's Lymphoma
Interventions: DRUG: Debio 1562|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Study With Trastuzumab, Pertuzumab and Letrozole in Breast Cancer Patients Sensitive to Hormonal Therapy
Status: COMPLETED
Conditions: Endocrine Sensitive HER2+/HR+ Breast Cancer
Interventions: DRUG: Pertuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Experience With a Tensor Fasciae Latae Perforator Flap Based on Septocutaneous Perforators
Status: COMPLETED
Conditions: Soft Tissue Defect
Interventions: OTHER: septocutaneous perforator flap
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Cannabis in Tourette Syndrome
Status: TERMINATED
Conditions: Tourette Syndrome
Interventions: DRUG: Cannabis|DRUG: Cannabis|DRUG: Cannabis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Augmented-reality Based Mirror Therapy in Stroke Rehabilitation
Status: RECRUITING
Conditions: Stroke|Rehabilitation|Technology|Mirror Movement Therapy
Interventions: OTHER: Traditional occupational therapy|OTHER: Mirror therapy using a mirror box|OTHER: Augmented reality-based mirror therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Resuscitation of Infants With Congenital Diaphragmatic Hernia With an Intact Umbilical Cord
Status: COMPLETED
Conditions: Congenital Diaphragmatic Hernia
Interventions: PROCEDURE: Congenital diaphragmatic hernia resuscitation with an intact umbilical cord
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of PegIntron Plus Ribavirin for Treatment of Chronic Hepatitis C in HIV-Infected Subjects (Study P04469)(TERMINATED)
Status: TERMINATED
Conditions: Hepatitis C, Chronic|Hepacivirus|HIV Infections
Interventions: BIOLOGICAL: Peginterferon alfa-2b (SCH 054031)|DRUG: Ribavirin (SCH 018908)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Simple Continuous Positive Airway Pressure on Patients With Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive|Continuous Positive Airway Pressure|Polysomnography
Interventions: DEVICE: Simple CPAP+Conventional fixed CPAP|DEVICE: Simple CPAP + Auto CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating Three-Dimensional Versus Two-Dimensional Imaging in Laparoscopic Cholecystectomies
Status: COMPLETED
Conditions: Gall Bladder Disease
Interventions: DEVICE: 3D Laparoscopic visual system|DEVICE: 2D Laparoscopic visual system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Multicenter, Prospective, Randomized, Double-Blind, Placebo-Controlled Trial of Three Preparations of Low-Dose Oral Alpha Interferon in HIV-Infected Patients With CD4+ Counts >= 50 and <= 350 Cells/mm3
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Interferon alfa-n3|DRUG: Interferon alfa-n1
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study on the Interaction Between Danoprevir/Ritonavir and Methadone
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: danoprevir|DRUG: methadone|DRUG: ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Proton Pump Inhibitor Versus Histamine-2 Receptor Antagonist for the Prevention of Recurrent Peptic Ulcers
Status: COMPLETED
Conditions: Peptic Ulcer
Interventions: DRUG: histamine-2 receptor antagonist group|DRUG: proton pump inhibitor group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oral Immunonutrition With Synbiotics, Omega 3 and Vitamin D in Patients Undergoing Duodenopancreatectomy for Tumoral Lesion.
Status: RECRUITING
Conditions: Pancreatic Cancer|Complication,Postoperative|Surgery
Interventions: DIETARY_SUPPLEMENT: Nutritional Products
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION