pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluation of Two Doses of QVAR Versus Placebo by Breath Operated and Metered Dose Inhalers in Moderate Asthmatic Adolescents and Adults on a Stable Regimen of Inhaled Corticosteroids
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: beclomethasone dipropionate (QVAR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Value of Early Mobilization and Physiotherapy Following Wrist Fractures Treated by Volar Plating
Status: COMPLETED
Conditions: Distal Radius Fracture|Wrist Fracture
Interventions: OTHER: Early mobilization|OTHER: Late mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About ABRYSVO Vaccine in Older Adults to Prevent Severe Respiratory Syncytial Virus (RSV) Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Respiratory Syncytial Viruses
Interventions: BIOLOGICAL: Prior standard of care receipt of Pfizer's ABRYSVO vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cisplatin With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Recurrent or Metastatic Head and Neck Cancer
Status: TERMINATED
Conditions: Recurrent Hypopharyngeal Squamous Cell Carcinoma|Recurrent Laryngeal Squamous Cell Carcinoma|Recurrent Laryngeal Verrucous Carcinoma|Recurrent Lip and Oral Cavity Squamous Cell Carcinoma|Recurrent Metastatic Squamous Cell Carcinoma in the Neck With Occult Primary|Recurrent Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Recurrent Oral Cavity Verrucous Carcinoma|Recurrent Oropharyngeal Squamous Cell Carcinoma|Squamous Cell Carcinoma Metastatic in the Neck With Occult Primary|Stage IV Hypopharyngeal Squamous Cell Carcinoma|Stage IVA Laryngeal Squamous Cell Carcinoma|Stage IVA Laryngeal Verrucous Carcinoma|Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma|Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage IVA Oral Cavity Verrucous Carcinoma|Stage IVA Oropharyngeal Squamous Cell Carcinoma|Stage IVB Laryngeal Squamous Cell Carcinoma|Stage IVB Laryngeal Verrucous Carcinoma|Stage IVB Lip and Oral Cavity Squamous Cell Carcinoma|Stage IVB Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage IVB Oral Cavity Verrucous Carcinoma|Stage IVB Oropharyngeal Squamous Cell Carcinoma|Stage IVC Laryngeal Squamous Cell Carcinoma|Stage IVC Laryngeal Verrucous Carcinoma|Stage IVC Lip and Oral Cavity Squamous Cell Carcinoma|Stage IVC Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage IVC Oral Cavity Verrucous Carcinoma|Stage IVC Oropharyngeal Squamous Cell Carcinoma|Tongue Carcinoma
Interventions: DRUG: Cisplatin|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|OTHER: Placebo|DRUG: WEE1 Inhibitor AZD1775
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Skeletal Muscle and Adipose Tissue Study
Status: COMPLETED
Conditions: Idiopathic Scoliosis
Interventions: DRUG: Bolus dose of Cefazolin|DRUG: Continuous Cefazolin drip|DEVICE: Paraspinal muscle microdialysis catheters|DEVICE: Subcutaneous microdialysis catheters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Remote Motivational Enhancement & MySafeRx on Post-Detox Engagement in B/N Treatment -RCT
Status: WITHDRAWN
Conditions: Opioid-use Disorder
Interventions: OTHER: MySafeRx™|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Scar Tissue Analysis After Intraoperative Application of Stromal Vascular Fraction Cells Into Suture Line
Status: UNKNOWN
Conditions: Wound Heal|Scar|Hypertrophic Scar|Delayed Wound Healing
Interventions: PROCEDURE: Intradermal stromal vascular fraction injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Progesterone on IV Nicotine Induced Changes on BOLD fMRI Signal, Hormones and Subjective Ratings of Stimulant Drugs
Status: WITHDRAWN
Conditions: Nicotine Dependence
Interventions: DRUG: Intravenous Nicotine|DRUG: Progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of JNJ-77242113 in Participants With Moderate-to-severe Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: JNJ-77242113|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Long Volume Reduction by Endobronchial Valves in Belgium
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: endobronchial valves|BEHAVIORAL: physical activity tele coaching|PROCEDURE: Lung volume reduction surgery (LVRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sevoflurane and Intravenous Anesthesia in Hypospadias Repair
Status: RECRUITING
Conditions: Emergence Delirium|Intravenous Anesthesia|Sevoflurane
Interventions: DRUG: sevoflurane|DRUG: propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cell Therapy Using Umbilical Cord-derived Mesenchymal Stromal Cells in SARS-CoV-2-related ARDS
Status: COMPLETED
Conditions: Severe Acute Respiratory Syndrome Coronavirus 2|Severe Acute Respiratory Distress Syndrome
Interventions: BIOLOGICAL: Umbilical cord Wharton's jelly-derived human|OTHER: NaCl 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combined PSMA PET/MRI for Detection of Lymph Node Metastases in High-risk Prostate Cancer Patients
Status: RECRUITING
Conditions: Prostatic Neoplasms|Neoplasm Metastasis
Interventions: DIAGNOSTIC_TEST: PSMA-PET|DIAGNOSTIC_TEST: PSMA-PET/MRI|DIAGNOSTIC_TEST: PSMA-PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of FID 114657 on Tear Film Lipid Layer Thickness
Status: COMPLETED
Conditions: Dry Eye
Interventions: OTHER: FID 114657|OTHER: OPTIVE Lubricant Eye Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sugammadex After Continuous Infusion of Rocuronium During Sevoflurane and Propofol Anesthesia (P05949; MK-8616-028)
Status: COMPLETED
Conditions: Anesthesia, General
Interventions: DRUG: Sugammadex|DRUG: Rocuronium|DRUG: Sevoflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Monitoring of Palliative Care Needs in Specialized Palliative Home Care Using the Electronic Version of the Integrated Palliative Care Outcome Scale
Status: COMPLETED
Conditions: Advanced Disease
Interventions: DEVICE: eIPOS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Recovery of Soccer Players After Anterior Cruciate Ligament Reconstruction.
Status: COMPLETED
Conditions: Knee Injuries and Disorders
Interventions: PROCEDURE: ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION WITH QUADRICEPS TENDON WITH BONE GRAFT|PROCEDURE: ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION WITH HAMSTRING TENDON GRAFT|PROCEDURE: ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION WITH QUADRICEPS TENDON WITHOUT BONE GRAFT|OTHER: Rehabilitation protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Team Clinic: Virtual Expansion of an Innovative Multi-Disciplinary Care Model for Adolescents and Young Adults With Type 1 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 1 Diabetes
Interventions: OTHER: Team Clinic Care|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SNIFF 120: Study of Nasal Insulin to Fight Forgetfulness (120 Days)
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Alzheimer's Disease
Interventions: DRUG: Regular Insulin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Ferric Carboxymaltose (Ferinject) in Patients Undergoing Orthopaedic Surgery
Status: TERMINATED
Conditions: Anemia|Orthopedic Surgery|High Risk of Blood Loss
Interventions: DRUG: Ferinject 50 mg/ml|DRUG: NaCl 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Photobiomodulation Therapy and Nerve Density for Patients With Diabetic or Chemotherapy-associated Neuropathy
Status: COMPLETED
Conditions: Neuropathy|Neuropathy, Diabetic|Neuropathy Toxic
Interventions: DEVICE: Realief Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LATERAL PHARYNGOPLASTY OUTCOMES IN THE TREATMENT OF SNORE AND OBSTRUCTIVE SLEEP APNEA
Status: UNKNOWN
Conditions: Snore|Obstructive Sleep Apnea
Interventions: PROCEDURE: Lateral Pharyngoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Comparison of Topical and Intravenous Tranexamic Acid to Reduce the Number of Blood Transfusions in TKA
Status: COMPLETED
Conditions: Blood Loss
Interventions: DRUG: Tranexamic Acid|DRUG: Tranexamic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of GBT440 Administered to Subjects With IPF on Supplemental Oxygen at Rest
Status: TERMINATED
Conditions: Idiopathic Pulmonary Fibrosis|Hypoxemia
Interventions: DRUG: GBT440
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluating the Effectiveness of a Stepped-Care Approach to Long-Term Weight Loss (The Step-Up Study)
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Standard Behavioral Weight Loss Program|BEHAVIORAL: Stepped-Care Weight Loss Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Design and Testing of a Web-Based Tool for the Improvement of End-of-Life Planning in Patients With Advanced Cancer
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid System Neoplasm|Locally Advanced Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm
Interventions: OTHER: Best Practice|OTHER: Internet-Based Intervention|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ultrasonographic Evaluation of the Diaphragm During NHF Versus NIV Use in Respiratory Failure
Status: UNKNOWN
Conditions: Diaphragm Issues|Respiratory Failure With Hypoxia|Respiratory Failure With Hypercapnia|Non-invasive Mechanical Ventilation
Interventions: DIAGNOSTIC_TEST: DTEE|DIAGNOSTIC_TEST: DTEI|DIAGNOSTIC_TEST: DEx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor Stem Cell Transplant With or Without Chemotherapy in Treating Children With Primary Myelodysplastic Syndrome
Status: UNKNOWN
Conditions: Leukemia|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: DRUG: cytarabine|DRUG: mercaptopurine|OTHER: laboratory biomarker analysis|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: biopsy|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Dose-Ranging Study Evaluating the Safety and Efficacy of IDP-108 in Patients With Onychomycosis
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DRUG: Low Strength IDP-108|DRUG: High Strength IDP-108|DRUG: High Strength IDP-108 under occlusion|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Surgical and Patient Reported Outcomes of Robotic Nipple-Sparing Mastectomy
Status: SUSPENDED
Conditions: Breast Cancer|Surgery--Complications|Genetic Predisposition to Disease|Surgery|BRCA1 Mutation|BRCA2 Mutation|Breast Diseases
Interventions: PROCEDURE: Robotic Nipple-Sparing Mastectomy (RNSM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-carbohydrate Versus Low-fat Breakfast in Type 2 Diabetes
Status: COMPLETED
Conditions: Dietary Habits
Interventions: OTHER: Low-Carb High-Fat breakfast|OTHER: Low fat "standard care" control breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lung Health Study (LHS) I and III
Status: COMPLETED
Conditions: Lung Diseases|Lung Diseases, Obstructive|Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: smoking cessation|DRUG: ipratropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Study To Evaluate The Efficacy And Safety Profile Of PF-06651600 And PF-06700841 In Subjects With Alopecia Areata
Status: COMPLETED
Conditions: Alopecia Areata
Interventions: DRUG: PF-06651600|DRUG: PF-06700841|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemoembolisation of Hepatocellular Carcinomas Not Subject to Interventive Care by Idarubicin-loaded Beads - IDASPHERE II
Status: COMPLETED
Conditions: Liver Cancer
Interventions: DRUG: idarubicin|DEVICE: Dc- Beads 300-500µm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of a Method to Measure mRNA Levels in Skin Samples
Status: COMPLETED
Conditions: Healthy|Atopic Dermatitis Eczema|Psoriasis
Interventions: OTHER: Skin squame collection|OTHER: Tape strip collection|OTHER: Tape strip and skin biopsy collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Outcomes of CRT and MitraClip for Treatment of Low Ejection Fraction and Functional Mitral Regurgitation in HF
Status: WITHDRAWN
Conditions: Functional Mitral Regurgitation|Heart Failure
Interventions: DEVICE: MitraClip|DRUG: Optimal Medical Therapy|DEVICE: CRT-D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effect of Hippotherapy Simulator in Children With Spastic Diplegia and Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy|Balance; Distorted|Walking, Difficulty
Interventions: OTHER: traditional physiotherapy|OTHER: hippotherapy-assisted physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physiological Changes in Adults With Metabolic Syndrome Exposed to Ultrafine Air Particles
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: OTHER: Ultrafine Air Pollution Particulate Matter|OTHER: Filtered Air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PET/CT and WB MRI for Staging and Response in CRPC Patients Receiving Enzalutamide
Status: COMPLETED
Conditions: Prostate Cancer Metastatic
Interventions: DRUG: Enzalutamide|DEVICE: 18-FDG PET/CT|DEVICE: Whole body MRI|DEVICE: Bone scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Succinylcholine Versus Rocuronium for Emergency Intubation in Intensive Care
Status: COMPLETED
Conditions: Intubation
Interventions: DRUG: Succinylcholine|DRUG: Rocuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PT005 MDI Dose Ranging Versus Foradil Aerolizer Study
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: PT005 MDI|DRUG: Formoterol Fumarate 12 μg (Foradil® Aerolizer®)|DRUG: Formoterol Fumarate 24 μg (Foradil® Aerolizer®)|OTHER: Placebo MDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First in Human Study of RVP-001, a New Manganese Based MRI Contrast Agent
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: RVP-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Balanced Salt Solution Versus 0.9% Saline Infusion for Prevention of Contrast-induced Acute Kidney Injury (BASIC Trial)
Status: COMPLETED
Conditions: Acute Kidney Injury|Renal Insufficiency, Chronic|Contrast Media Reaction
Interventions: DRUG: CJ Plasma Solution A Injection|DRUG: CJ 0.9% Normal Saline Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bioavailability of Select Nutrients From Two Formulations of a Multivitamin/Mineral Supplement
Status: COMPLETED
Conditions: Bioavailability
Interventions: DIETARY_SUPPLEMENT: Formulation #1|DIETARY_SUPPLEMENT: Formulation #2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of DP-R212
Status: WITHDRAWN
Conditions: Hypertension|Hypercholesterolemia
Interventions: DRUG: DP-R212|DRUG: C1-R212|DRUG: C2-R212
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Safety and Efficacy Study of Bevirimat Functional Monotherapy in HIV Treatment-Experienced Patients for 2 Weeks*
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: matching placebo|DRUG: Bevirimat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Submucosal Dissection (ESD) Versus Endoscopic Mucosal Resection (EMR) for Large Non Pedunculated Colonic Adenomas: a Randomized Comparative Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Colonic Polyp
Interventions: PROCEDURE: Experimental procedure : ESD|PROCEDURE: Comparison procedure: WF-piece meal EMR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Biomarker Study in Patients With HER2-negative Metastatic Breast Cancer Treated With Bevacizumab and Paclitaxel
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Bevacizumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Control in Patients With Recurrent or Metastatic Breast or Prostate Cancer
Status: TERMINATED
Conditions: Breast Cancer|Pain|Prostate Cancer
Interventions: BEHAVIORAL: Observation|BEHAVIORAL: Educational Intervention and Behavioral Skills Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Use of a Respiratory Care Model in Population Older Than 15 Years in Orizaba, Veracruz Mexico
Status: COMPLETED
Conditions: Respiratory Disease
Interventions: BEHAVIORAL: Integral Action Program for Respiration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Proof-of-concept Study on Disinfection and Healing Acceleration Capabilities of 222nm Wave Length Narrow Band Ultraviolet Lighting Device
Status: COMPLETED
Conditions: Ultraviolet Rays
Interventions: DEVICE: SafeZoneUVC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Durable Effect of Imeglimin on the Glycemic Control in Patients With Type 2 Diabetes Mellitus
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Imeglimin|DRUG: Metformin|DRUG: Vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Coasting by Withholding GnRH Agonist With GnRH Antagonist
Status: UNKNOWN
Conditions: In Vitro Fertilization
Interventions: PROCEDURE: GnRH antagonist|PROCEDURE: withdrawing GnRH agonists
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Nerve Denervation After Pulmonary Vein Isolation for Persistent Atrial Fibrillation
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Renal Nerve Denervation|PROCEDURE: Pulmonary vein isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Pain on Exercise-induced Hypoalgesia
Status: COMPLETED
Conditions: Pain|Healthy
Interventions: BEHAVIORAL: Pain (hypertonic saline)|BEHAVIORAL: No pain (Isotonic saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate Efficacy and Safety of Infliximab in Participant With Moderate-to-Severe Refractory Intestinal Behcet's Disease
Status: COMPLETED
Conditions: Behcet Disease
Interventions: DRUG: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on Combined Immune Effect of EV71 Inactivated Vaccine
Status: UNKNOWN
Conditions: Enterovirus 71 Inactivated Vaccine|HFMD
Interventions: BIOLOGICAL: EV71 (inoculation vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Aqueous Mushroom Extract and Intraocular Pressure
Status: UNKNOWN
Conditions: Glaucoma
Interventions: DRUG: OME|DRUG: OME|DRUG: OME|DRUG: OME|DRUG: OME|DRUG: OME
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Immunogenicity and Safety of Inactivated and Live Attenuated Hepatitis A Vaccines in Young Adults
Status: COMPLETED
Conditions: Hepatitis A
Interventions: BIOLOGICAL: Inactivated HAV vaccine|BIOLOGICAL: Live attenuated HAV vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Titratable Dosing in Moderate to Severe Asthmatics
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: budesonide/formoterol|DRUG: Symbicort pMDI + budesonide HFA pMDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Magnetic Stimulation in Depression
Status: COMPLETED
Conditions: Depression
Interventions: PROCEDURE: Repetitive transcranial magnetic stimulation (rTMS)|PROCEDURE: Sham rTMS|DEVICE: Repetitive Transcranial Magnetic Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ACB A Randomized Study of 2.5ug/kg/Day vs. 5ug/kg/Day Dose of G-CSF After High Dose Chemotherapy Followed by Autologous Peripheral Blood Stem Cell/Marrow Transplant Recipients FILE#17159
Status: COMPLETED
Conditions: Peripheral Stem Cell/Marrow Transplant
Interventions: DRUG: G-CSF/Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Premedication on the Success Rate of Inferior Alveolar Nerve Block
Status: COMPLETED
Conditions: Symptomatic Irreversible Pulpitis
Interventions: DRUG: Dexamethasone 0.5mg|DRUG: Ketorolac 10 Mg Oral Tablet|DRUG: Meloxicam 7.5 mg|DRUG: Ibuprofen 600 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Food Effect on the Pharmacokinetics of CM082 Tablet in Chinese Healthy Volunteers
Status: COMPLETED
Conditions: Advanced Malignant Solid Tumors
Interventions: DRUG: CM082 with fed or fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantification of the Airflow Into Sinuses Before and After ArchSinus Implantation
Status: NOT_YET_RECRUITING
Conditions: Chronic Sinusitis, Ethmoidal
Interventions: DEVICE: ArchSinus implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Efficacy of rhNGF Eye Solution vs Vehicle in Patients With Moderate to Severe Dry Eye
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: rhNGF 20 μg/ml|DRUG: rhNGF 20 μg/ml + vehicle|OTHER: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Compare the Efficacy and Safety of LAYLA in Osteoarthritis Patients
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: LAYLA tablet|DRUG: JOINS tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cystic Fibrosis Related Diabetes Screening.
Status: COMPLETED
Conditions: Cystic Fibrosis-related Diabetes
Interventions: OTHER: glucose solution at a dose of 1.75 g/kg (up to a maximum of 75 g) for the OGTT and glucose solution at a dose of 0.5 g/kg (up to a maximum of 35 g) was injected in 2.5-3 min for the IGTT|PROCEDURE: HGPIV diagnosis test|PROCEDURE: HOMAR-IR diagnosis test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Triple Antimalarial Combination to Accelerate the Parasite Clearance and to Prevent the Selection of Resistant Parasites
Status: UNKNOWN
Conditions: Plasmodium Falciparum Malaria (Drug Resistant)
Interventions: DRUG: Imatinib|DRUG: Dihydroartemisinin-piperaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Modification and Lorcaserin for Weight Loss Maintenance
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Lorcaserin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: European Quality of Care Pathways Study on Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: COPD evidence based care pathway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of MK-3475 (Pembrolizumab) in Patients With Microsatellite Unstable (MSI) Tumors (Cohort D)
Status: ACTIVE_NOT_RECRUITING
Conditions: High Tumor Mutation Burden|High TMB (Tumor Mutation Burden)|MSS (Microsatellite Stable)
Interventions: DRUG: MK-3475
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Auranofin for Giardia Protozoa
Status: COMPLETED
Conditions: Amoebic Dysentery|Giardiasis
Interventions: DRUG: Auranofin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Coronary Lithoplasty and Rotablation
Status: COMPLETED
Conditions: Coronary Artery Disease|Calcified Atheroma
Interventions: PROCEDURE: Rotablation|PROCEDURE: Coronary Lithoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Study of XZP-3621 Tablet
Status: UNKNOWN
Conditions: Healthy Subjects
Interventions: DRUG: XZP-3621 tablet and itraconazole oral liquid (for Arm1)|DRUG: XZP-3621 tablet and Rifampicin capsules (For Arm 2)|DRUG: XZP-3621 tablet and esomeprazole tablet (For Arm3)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality During Intrathecal Pump Refills in Children
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: Intrathecal pump refill with Virtual Reality|OTHER: Intrathecal pump refill with distraction|OTHER: Intrathecal pump refill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: iTBS to Enhance Social Cognition in People With Psychosis
Status: RECRUITING
Conditions: Schizophrenia|Schizo Affective Disorder|Schizophreniform Disorders|Psychosis Nos/Other
Interventions: DEVICE: iTBS (Active)|DEVICE: iTBS (Sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Shockwave Therapy (ESWT) to Improve Function in Chronic ASIA-A Patients
Status: UNKNOWN
Conditions: Spinal Cord Injuries
Interventions: DEVICE: ESWT|DEVICE: Placebo ESWT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erlotinib Plus Pemetrexed to Treat Lung Adenocarcinoma With Brain Metastases
Status: COMPLETED
Conditions: Lung Adenocarcinoma|Brain Metastases
Interventions: DRUG: erlotinib|DRUG: pemetrexed|DRUG: cisplatin|DRUG: erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calcium From Fish Bone in Volunteers With Osteopenia
Status: UNKNOWN
Conditions: Osteopenia
Interventions: DIETARY_SUPPLEMENT: Calcium from fish bone|DIETARY_SUPPLEMENT: Calcium carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Brief Intervention for Medication Overuse Headache
Status: COMPLETED
Conditions: Medication-overuse Headache|Chronic Headache
Interventions: BEHAVIORAL: Brief intervention|OTHER: Business as usual|OTHER: Screening and outcome evaluation only|OTHER: Screening and outcome evaluation only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Dexmedetomidine on Perfusion Index and Microcirculation in Severe Sepsis and Septic Shock Patients
Status: UNKNOWN
Conditions: Septic Shock
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Non-small Cell Lung Cancer Study US75 (Z-PACT)
Status: COMPLETED
Conditions: Non Small Cell Lung Carcinoma
Interventions: DRUG: zoledronic acid|DRUG: Taxotere|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PICU Up!: A Pilot Stepped-wedge Trial of a Multicomponent Early Mobility Intervention for Critically Ill Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Critical Illness
Interventions: OTHER: PICU Up!
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Fludarabine, Busulfan, Antithymocyte Globulin, and Donor Stem Cell Transplant in Treating Patients With Multiple Myeloma That Has Not Responded to Treatment
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: anti-thymocyte globulin|DRUG: busulfan|DRUG: fludarabine phosphate|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: nonmyeloablative allogeneic hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TONKA Versus Legalon for Lowering Hepatic Enzymes in Liver Function Disorder Patients.
Status: UNKNOWN
Conditions: Liver Function Failure
Interventions: DRUG: TONKA|DRUG: LEGALON
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ICU Follow-up After Prolonged Intensive Care Stay
Status: COMPLETED
Conditions: Critical Illness|PICS|Post Intensive Care Syndrome
Interventions: OTHER: ICU follow-up clinic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Evaluate the Safety and Efficacy of Lenacapavir (GS-6207) in Combination With an Optimized Background Regimen (OBR) in Heavily Treatment Experienced Participants Living With HIV-1 Infection With Multidrug Resistance
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV-1-infection
Interventions: DRUG: Oral Lenacapavir|DRUG: Oral Lenacapavir Placebo|DRUG: Subcutaneous Lenacapavir|DRUG: Failing ARV Regimen|DRUG: Optimized Background Regimen (OBR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Interaction Between Vicodin® CR and Ethanol in Healthy Male and Female Moderate Alcohol Drinkers
Status: COMPLETED
Conditions: Drug Interactions
Interventions: DRUG: Vicodin® CR (extended-release hydrocodone/acetaminophen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: RESOLUTE China RCT
Status: COMPLETED
Conditions: Ischemic Heart Disease|Stenotic Coronary Lesion|Cardiovascular Diseases|Arteriosclerosis|Coronary Artery Disease
Interventions: DEVICE: Taxus Liberte Paclitaxel-Eluting Coronary Stent System|DEVICE: Resolute Zotarolimus-Eluting Coronary Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Post-marketing Observational Study Of The Use Of Zonisamide (ZNS) in the Adjunctive Treatment Of Adult Patients With Partial Onset Seizures (Study E2090-E044-410) (ZOOM)
Status: COMPLETED
Conditions: Partial Onset Seizures
Interventions: DRUG: Zonisamide tablets
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Field of Effects of Two Commercial Preparations of Botulinum Toxin Type A
Status: COMPLETED
Conditions: Wrinkles in Frontal Area
Interventions: DRUG: Botulinum Toxin Type A (Dysport®)|DRUG: Botulinum Toxin Type A/Botox®|DRUG: Botulinum Toxin Type A/Dysport®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Letrozole Given Alone to Letrozole Given With Avastin in Post-Menopausal Women Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Cancer of the Breast|Breast Neoplasm
Interventions: OTHER: Letrozole (Femara)|DRUG: Letrozole; Avastin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BAT1308 in Combination With Platinum-containing Chemotherapy is Used for the First-line Treatment of Advanced or Recurrent dMMR Endometrial Cancer
Status: RECRUITING
Conditions: Endometrial Cancer
Interventions: DRUG: carboplatin|DRUG: Paclitaxel|DRUG: Recombinant humanized anti-PD-1 monoclonal antibody injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Olaparib for Patients With Recurrent BRCA Deficient Ovarian Cancer
Status: WITHDRAWN
Conditions: Ovarian Cancer|Peritoneal Cancer|Fallopian Tube Cancer
Interventions: DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NRX-101 for Maintenance of Remission From Severe Bipolar Depression in Patients With Suicidal Ideation
Status: ACTIVE_NOT_RECRUITING
Conditions: Bipolar Depression|Suicidal Ideation
Interventions: DRUG: NRX-101|DRUG: Lurasidone HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spearhead 1 Study in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma
Status: RECRUITING
Conditions: Synovial Sarcoma|Myxoid Liposarcoma
Interventions: GENETIC: afamitresgene autoleucel (previously ADP-A2M4)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trebananib With or Without Low-Dose Cytarabine in Treating Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Recurrent Adult Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: BIOLOGICAL: trebananib|DRUG: cytarabine|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)
Status: COMPLETED
Conditions: Treatment Resistant Depression|Electroconvulsive Therapy|ECT|Ketamine|Psychiatric Disorder|Depression|Major Depressive Disorder|Major Depressive Episode|Unipolar Depression
Interventions: PROCEDURE: electroconvulsive therapy (ECT)|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Sodium to Preserve Renal EfficiencY in Acute Heart Failure
Status: ACTIVE_NOT_RECRUITING
Conditions: Volume Overload
Interventions: DIETARY_SUPPLEMENT: Oral Sodium Chloride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dexcom G6 Intervention Study
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: Dexcom G6 CGM - Continues Glucose Monitoring sensor system|DIAGNOSTIC_TEST: POC BG - Point-of-Care Blood Glucose monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Lateral Bony Wall Repositioning in Maxillary Sinus Floor Augmentation
Status: COMPLETED
Conditions: Maxillary Sinus Augmentation
Interventions: PROCEDURE: Maxillary sinus augmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carboplatin/Taxol/Ridaforolimus in Endometrial, Ovarian and Solids
Status: COMPLETED
Conditions: Endometrial Cancer|Ovarian Cancer
Interventions: DRUG: Ridaforolimus|DRUG: Paclitaxel|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative OCT Guidance of Intraocular Surgery II
Status: RECRUITING
Conditions: Macular Holes|Epiretinal Membrane|Diabetic Retinopathy|Retinal Detachment|Retinal Disease|Preretinal Fibrosis|Cataract|Ocular Tumor|Strabismus|Healthy
Interventions: DEVICE: Microscope integrated optical coherence tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study by ChromaDex to Assess the Effects of TRU NIAGEN on Cognitive Function, Mood and Sleep in Older Adults
Status: COMPLETED
Conditions: Cognitive Function|Mood|Sleep
Interventions: DIETARY_SUPPLEMENT: 300 mg/day of TRU NIAGEN (nicotinamide riboside)|DIETARY_SUPPLEMENT: 1000 mg/day of TRU NIAGEN (nicotinamide riboside)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Anticoagulant After Implantation of Biological Aortic Valve Comparing With Aspirin
Status: COMPLETED
Conditions: Thromboembolism|Bleeding
Interventions: DRUG: Aspirin|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Anatomy of Major Duodenal Papilla on the Difficulty of Cannulation During Endoscopic Retrograde Cholangiopancreatography
Status: COMPLETED
Conditions: Pancreaticobiilary Diseases|Endoscopic Retrograde Cholangiopancreatography
Interventions: OTHER: MDP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Evaluating HC-1119 Single-Dose Pharmacokinetics and Effect of Food on Its Pharmacokinetics
Status: COMPLETED
Conditions: Metastatic Castration Resistant Prostate Cancer
Interventions: DRUG: HC1119
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cytodiagnosis of Basal Cell Carcinoma and Actinic Keratosis Using Papanicolaou and May-grunwald-giemsa Stained Tissue Smear
Status: COMPLETED
Conditions: Carcinoma, Basal Cell|Porokeratosis, Disseminated Superficial Actinic
Interventions: PROCEDURE: Skin scrape
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Twice Daily Altabax Application for the Treatment of Uncomplicated Soft Tissue Infection
Status: COMPLETED
Conditions: Impetigo|Folliculitis|Secondarily Infected Eczema|Minor Soft Tissue Infections
Interventions: DRUG: Retapamulin (Altabax)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abemaciclib Plus Darolutamide in Prostate Cancer That Has Spread After Initial Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostatic Neoplasms
Interventions: DRUG: Abemaciclib|DRUG: Darolutamide|DRUG: LHRH agonist/antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of CPAP With SOMNOventCR in Patients With Underlying Heart Disease, Combined OSA and CSR
Status: COMPLETED
Conditions: Heart Diseases|Sleep Apnea, Central|Sleep Apnea, Obstructive
Interventions: DEVICE: CPAP before SOMNOVentCR|DEVICE: SOMNOventCR before CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Continuous Potassium Chloride Infusion in Critical Care
Status: COMPLETED
Conditions: Hypokalemia|Arrhythmias, Cardiac
Interventions: DRUG: Sterile Potassium Chloride Concentrate|DRUG: Sterile Potassium Chloride Concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of a Learning Collaborative to Implement Health Promotion in Mental Health
Status: UNKNOWN
Conditions: Health Promotion|Obesity|Organizational Innovation|Mental Health Services
Interventions: OTHER: Virtual Learning Collaborative|OTHER: Technical Assistance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH