pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy/Safety of Ecraprost in Lipid Emulsion for Treatment of Critical Leg Ischemia Due to Peripheral Arterial Disease
Status: TERMINATED
Conditions: Peripheral Vascular Disease
Interventions: DRUG: Ecraprost in lipid emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of HTD1801 in Adults With Nonalcoholic Steatohepatitis (NASH) and Type 2 Diabetes Mellitus (T2DM)
Status: COMPLETED
Conditions: Fatty Liver, Nonalcoholic|NAFLD|Nonalcoholic Fatty Liver Disease|Nonalcoholic Steatohepatitis|Digestive System Diseases|Type 2 Diabetes Mellitus (T2DM)
Interventions: DRUG: HTD1801|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability of CAEL-101 in Patients With AL Amyloidosis
Status: COMPLETED
Conditions: AL Amyloidosis
Interventions: DRUG: CAEL-101|DRUG: SoC: cyclophosphamide, bortezomib, and Dexamethasone (CyBorD)|DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cartoon Distraction and Parental Presence on Anxiety in Pediatric Anesthesia
Status: COMPLETED
Conditions: Anxiety, Separation|Psychomotor Agitation
Interventions: BEHAVIORAL: Cartoon|BEHAVIORAL: parental presence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetic Study Comparing Tiotropium Easyhaler® and Spiriva® HandiHaler®
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Tiotropium Bromide Monohydrate|DRUG: Tiotropium Bromide Monohydrate|DRUG: Tiotropium Bromide Monohydrate|DRUG: Tiotropium Bromide Monohydrate|DRUG: Tiotropium Bromide Monohydrate|DRUG: Tiotropium Bromide Monohydrate|DRUG: Tiotropium Easyhaler with oral activated charcoal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Exploratory Study of TG02-treatment as Monotherapy or in Combination With Pembrolizumab to Assess Safety and Immune Activation in Patients With Locally Advanced Primary and Recurrent Oncogenic RAS Exon 2 Mutant Colorectal Cancer
Status: TERMINATED
Conditions: Rectal Cancer
Interventions: BIOLOGICAL: TG02-treatment|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Maintenance Dose Ticagrelor Versus Clopidogrel in Diabetes Patients Undergoing PCI
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Coronary Artery Disease
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction Study Between Lumefantrine and Lopinavir/Ritonavir
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Lumefantrine - lopinavir/ritonavir drug interaction|DRUG: Lumefantrine only arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate the Effect of Eliglustat on the Pharmacokinetics, Safety and Tolerability of Metoprolol in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Eliglustat|DRUG: Metoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: EGFR-TKI With/Without Chemotherapy in NSCLC Patients With Both EGFR Mutation and BIM Deletion Polymorphism
Status: UNKNOWN
Conditions: Nonsmall Cell Lung Cancer|EGFR Gene Mutation
Interventions: DRUG: EGFR-TK Inhibitor|DRUG: EGFR-TKI|DRUG: EGFR-TKI and Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bladder Capacity as Objective Measure of Intravesical Treatment of Newly Diagnosed IC
Status: COMPLETED
Conditions: Interstitial Cystitis|Painful Bladder Syndrome
Interventions: DRUG: bupivacaine, triamcinolone, and heparin (BTH)|DRUG: dimethyl sulfoxide (DMSO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Children With Progressive Brain Tumors
Status: COMPLETED
Conditions: Brain Tumors|Central Nervous System Tumors
Interventions: DRUG: carboplatin|DRUG: lomustine|DRUG: procarbazine hydrochloride|DRUG: thioguanine|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double Blind Study of Hypertonic Saline vs Mannitol in the Management of Increased Intracranial Pressure (ICP).
Status: WITHDRAWN
Conditions: Elevated Intracranial Pressure
Interventions: DRUG: hypertonic saline|DRUG: Mannitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Crossover Evaluation of Effect of Atorvastatin on PK of Irinotecan in CRC Patients Receiving FOLFIRI
Status: WITHDRAWN
Conditions: Advanced Adenocarcinoma of the Colon or Rectum
Interventions: DRUG: FOLFIRI.|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase III, Randomised Study of Adjuvant Dato-DXd in Combination With Rilvegostomig or Rilvegostomig Monotherapy Versus Standard of Care, Following Complete Tumour Resection, in Participants With Stage I Adenocarcinoma NSCLC Who Are ctDNA-positive or Have High-risk Pathological Features
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Datopotamab Deruxtecan|DRUG: Rilvegostomig|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Etoposide|DRUG: Pemetrexed|DRUG: Vinorelbine|DRUG: UFT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VTS-270 to Treat Niemann-Pick Type C1 (NPC1) Disease
Status: COMPLETED
Conditions: Niemann-Pick Disease, Type C
Interventions: DRUG: Parts A/B: Adrabetadex|OTHER: Parts A/B: Sham Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Visual and Refractive Outcomes After Implantation of Aspheric IOLs With Different Dioptric Increments and Manufacturing
Status: TERMINATED
Conditions: Cataract
Interventions: DEVICE: Intraocular Lens (IOL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gabapentin for the Reduction of Radiation Therapy Induced Pain During the Treatment of Oropharyngeal Cancer
Status: COMPLETED
Conditions: Oropharynx Cancer
Interventions: DRUG: Gabapentin|DRUG: Placebo Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: South Texas Early Prevention Studies SNAP-Ed (STEPS SNAP-Ed)
Status: ACTIVE_NOT_RECRUITING
Conditions: Health-Related Behavior
Interventions: BEHAVIORAL: Bienestar/Neema Coordinated School Health Program (BN CSHP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Hunger, Satiety, and Metabolic Responses to High-fat Meals of Varying Fatty Acid Composition
Status: UNKNOWN
Conditions: Body Weight Changes
Interventions: OTHER: MUFA-rich HF Meal|OTHER: PUFA-rich HF Meal|OTHER: SFA-rich HF Meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of KD026 in Combination With Metformin in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: KD026|DRUG: Placebo|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Meditation and Education That is Nurse Delivered for Symptom Management in Paroxysmal Atrial Fibrillation (PAF)
Status: RECRUITING
Conditions: Paroxysmal Atrial Fibrillation
Interventions: BEHAVIORAL: Meditation|OTHER: AF Education|OTHER: Phone Calls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Transversus Abdominis Plane (TAP) vs. Trigger Point Injection (TPI) for Abdominal Wall Pain
Status: COMPLETED
Conditions: Abdominal Pain
Interventions: DRUG: Bupivacaine 0.25%|DRUG: Triamcinolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Prostatic Arterial Embolization Versus a Sham Procedure to Treat Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Prostatic Hyperplasia, Benign|Prostatic Hypertrophy, Benign|Genital Diseases, Male|Lower Urinary Tract Symptoms|Prostatic Diseases
Interventions: PROCEDURE: Prostatic Arterial Embolization|PROCEDURE: Sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: REpurposing SirolimUS in Compensated Advanced Chronic Liver Disease. The RESUS Proof of Concept Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Chronic Liver Disease
Interventions: DRUG: Sirolimus 0.5Mg Tab|DIAGNOSTIC_TEST: 1st MRI scan|PROCEDURE: 1st Percutaneous or Endoscopic Ultrasound guided liver biopsy|DRUG: Placebo 0.5mg capsule|DIAGNOSTIC_TEST: Baseline Blood Tests|DIAGNOSTIC_TEST: Baseline Clinical Examination|DIAGNOSTIC_TEST: Week 1 - 5 Titration Blood Tests|OTHER: Month 2 Clinical Examination|DIAGNOSTIC_TEST: Month 2 Blood Tests|OTHER: Month 4 Clinical Examination|DIAGNOSTIC_TEST: Month 4 Blood Tests|OTHER: Month 6 Clinical Examination|DIAGNOSTIC_TEST: Month 6 Blood Tests|PROCEDURE: 2nd Percutaneous or Endoscopic Ultrasound guided liver biopsy|DIAGNOSTIC_TEST: 1st MRI scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quality of Life and Visual Acuity of Visglyc Eye Drops on Dry Eye Patients
Status: COMPLETED
Conditions: Dry Eye Syndromes|Cataract
Interventions: DEVICE: Vis Glyc Neo|DEVICE: Physiological saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Investigate the Effect of BMS-986142 on the Pharmacokinetics (PK) of Methotrexate and Probe Substrate Cocktail in Healthy Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Montelukast, Flurbiprofen, Midazolam, Digoxin, Pravastatin and BMS-986142|DRUG: Methotrexate, Leucovorin and BMS-986142
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Chidamide Plus CHOEP Combined With Upfront ASCT in Untreated Peripheral T-cell Lymphoma
Status: UNKNOWN
Conditions: T Cell Non-Hodgkin's Lymphoma
Interventions: DRUG: Chidamide|DRUG: Cyclophosphamide|DRUG: Epirubicin|DRUG: Vindesine|DRUG: Etoposide|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating a New Way of Giving Medicine to Newborn and Preterm Babies
Status: UNKNOWN
Conditions: Hypophosphataemia|Osteopenia of Prematurity
Interventions: DRUG: Oral thin film therapy (Potassium acid phosphate oral thin films)|DRUG: Standard therapy (Potassium acid phosphate oral solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of GSK Biologicals' HPV Vaccine 580299 in Healthy Japanese Females 10-15 Years of Age
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: BIOLOGICAL: Cervarix™ (HPV-16/18 L1 VLP AS04)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of INCB050465 in Relapsed or Refractory Mantle Cell Lymphoma Previously Treated With or Without a Bruton's Tyrosine Kinase (BTK) Inhibitor
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Parsaclisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Organic Anion Transporting Polypeptide (OATP) Transporter-Mediated Drug-Drug Interactions Between Filgotinib and Statins as Probe Drugs in Healthy Participants
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Atorvastatin|DRUG: Pravastatin|DRUG: Rosuvastatin|DRUG: Filgotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Multi-Center Study to Evaluate the Efficacy and Safety of KX01 Ointment 1% on Actinic Keratosis on Face or Scalp
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: KX01 ointment 1%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tildrakizumab Compared to Placebo in Subjects With Active Psoriatic Arthritis I (INSPIRE 1)
Status: RECRUITING
Conditions: Active Psoriatic Arthritis
Interventions: DRUG: TILD|DRUG: matching placebo injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Inspiratory Muscle Training on Cardiovascular Function in Hypertension.
Status: UNKNOWN
Conditions: Reduction of Blood Pressure in Hypertensive Patients.|Improvement of Cardiovascular Autonomic Control.|Improvement of Functional Capacity.|Improvement of Quality of Life.
Interventions: OTHER: Inspiratory Muscle Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Ultomiris® (Ravulizumab) Safety in Pregnancy
Status: RECRUITING
Conditions: Ultomiris-exposed Pregnant/ Postpartum|Pregnancy|Paroxysmal Nocturnal Hemoglobinuria (PNH)|Atypical Hemolytic Uremic Syndrome (aHUS)|Generalized Myasthenia Gravis (gMG)|Neuromyelitis Optica Spectrum Disorder (NMOSD)
Interventions: DRUG: Ultomiris
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Safety and Efficacy Study of Inhaled R940343 in Patients With Mild to Moderate Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Placebo|DRUG: R940343 1mg|DRUG: R940343 2mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Markers of Atherosclerosis in Overweight, Postmenopausal Women Following Daily Watermelon Consumption
Status: COMPLETED
Conditions: Postmenopausal|Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: Watermelon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Paracetamol Route in Palliative Care Patients (PARASCIVPALLIA)
Status: UNKNOWN
Conditions: Palliative Care
Interventions: OTHER: Paracetamol route in palliative-care patients: intravenous versus subcutaneous route Pharmacokinetics study protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Tibial Nerve Stimulation for Treating Neurogenic Lower Urinary Tract Dysfunction
Status: TERMINATED
Conditions: Neurogenic Bladder Dysfunction
Interventions: DEVICE: Transcutaneous Tibial Nerve Stimulation (TTNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Micro-osteoperforation on the Rate of Bone Anchored Molar Distalization
Status: RECRUITING
Conditions: Microosteoperforations
Interventions: PROCEDURE: micro osteo-perforation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Temazepam and Acetazolamide to Treat Difficulty Sleeping at High Altitude
Status: COMPLETED
Conditions: High-altitude Sleep Disturbance
Interventions: DRUG: Temazepam|DRUG: Acetazolamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dialectical Behavioral Therapy Skills for Impulsive Aggression
Status: ACTIVE_NOT_RECRUITING
Conditions: Impulsive Aggression|ADHD|Executive Dysfunction
Interventions: BEHAVIORAL: Dialectical behavioral therapy skills for the intervention experimental group A|DRUG: psychoeducation or Atomoxetine or stimulants according to ADHD severity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase IV Clinical Trial of an Inactivated Influenza Split Vaccine
Status: COMPLETED
Conditions: Human Influenza
Interventions: BIOLOGICAL: Inactivated influenza split vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis
Status: COMPLETED
Conditions: Tetraplegia|Spinal Cord Injury|Brachial Plexus Injury|Muscular Dystrophy|ALS|Brainstem Stroke
Interventions: DEVICE: Implantation of ECoG sensors on the brain surface
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Comparison of 3 in Vivo Microscopic Imaging Techniques for the Diagnosis of Pigmented Tumors
Status: COMPLETED
Conditions: Basal Cell Carcinoma|Lentigo Maligna|Melanoma|Nevus|Seborrheic Keratosis|Lentigo
Interventions: DIAGNOSTIC_TEST: Fluorescence-Advanced videodermatoscopy|DIAGNOSTIC_TEST: Reflectance confocal microscopy|DIAGNOSTIC_TEST: Super-high magnification dermoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Infusion of Prostacyclin (Iloprost) vs Placebo for 72-hours in Patients With Septic Shock Suffering From Organ Failure
Status: COMPLETED
Conditions: Septic Shock
Interventions: DRUG: Iloprost|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: the Condylar Response of Mini-plate Anchored Rigid Fixed Functional Appliance Versus Dentally Anchored Semi-rigid One
Status: COMPLETED
Conditions: Class II Malocclusion
Interventions: DEVICE: Herbst Group|DEVICE: TFBC Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Prexasertib (LY2606368) With Chemotherapy and Radiation in Participants With Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Neoplasms
Interventions: DRUG: Prexasertib|DRUG: Cisplatin|DRUG: Cetuximab|RADIATION: Intensity Modulated Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Discriminative Validity of Strain Elastography of the Supraspinatus Tendon
Status: COMPLETED
Conditions: Elasticity Imaging Techniques|Tendinopathy|Rotator Cuff Tendinitis|Musculoskeletal Disease
Interventions: DIAGNOSTIC_TEST: Diagnostic
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Effects of Single and Multiple Ascending Doses of GDC-0334 and the Effect of Food on the Pharmacokinetics of GDC-0334 in Healthy Adult Participants
Status: TERMINATED
Conditions: Healthy Volunteers
Interventions: DRUG: GDC-0334|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Weaning From Mechanical Ventilation Comparison of Open-loop Decision Support System and Routine Care
Status: UNKNOWN
Conditions: Respiration, Artificial
Interventions: DEVICE: open loop weaning group (Beacon)|OTHER: Routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Monitoring the Efficacy of a Probiotic Dietary Supplement SmartProbio C in Patients With Severe COVID-19 Infection
Status: COMPLETED
Conditions: COVID-19
Interventions: DIETARY_SUPPLEMENT: SmartProbio C|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Modified Bone Marrow Stem Cell Transplantation for Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia|Graft vs Host Disease
Interventions: DRUG: Modified bone marrow stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: BMN 673 (Talazoparib), an Oral PARP Inhibitor, in People With Deleterious BRCA1/2 Mutation-Associated Ovarian Cancer Who Have Had Prior PARP Inhibitor Treatment
Status: TERMINATED
Conditions: Ovarian Cancer
Interventions: DRUG: BMN 673 (talazoparib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A NOVel Moisturiser for Atopic Dermatitis: Effect on the Skin Barrier
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: 2% urea/20% glycerol cream|DRUG: Miniderm® 20% cream|DRUG: Diprobase® cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TriPRIL CAR T Cells in Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma|Multiple Myeloma in Relapse|Refractory Multiple Myeloma
Interventions: DRUG: TriPRIL CAR T Cells|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HIV Engagement and Adolescent Depression Support (HEADS-UP)
Status: NOT_YET_RECRUITING
Conditions: Depression|Anxiety|Adolescent Behavior|HIV Infections|Immune System Diseases
Interventions: BEHAVIORAL: Standard of Care (SOC)|BEHAVIORAL: Adapted Friendship Bench (AFB)|BEHAVIORAL: Enhanced Friendship Bench (EFB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of XmAb®7195 in Adult Healthy Volunteers and Adult Subjects With a History of Allergic Rhinitis and/or Allergic Conjunctivitis and/or Atopic Dermatitis
Status: COMPLETED
Conditions: Allergic Rhinitis|Allergic Conjunctivitis|Atopic Dermatitis
Interventions: BIOLOGICAL: XmAb7195|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Personalized Blood Pressure Management: IMPROVE-multi
Status: ACTIVE_NOT_RECRUITING
Conditions: Blood Pressure|Intraoperative Hypotension|Postoperative Complications|Surgery|Anesthesia
Interventions: OTHER: Personalized blood pressure management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Fluid Intolerance Signals as Safety Limits to Prevent Fluid-induced Harm During Septic Shock Resuscitation
Status: NOT_YET_RECRUITING
Conditions: Septic Shock
Interventions: OTHER: Intervention resuscitation|OTHER: Standard of Care resuscitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Procedure for Duodenum to Ileal Diversion to Treat Type 2 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 2 Diabetes|Obesity
Interventions: DEVICE: Magnet Anastomosis System|DRUG: Best Medical Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between GnRH Agonist and GnRH Antagonist Protocols of Ovarian Stimulation in PCOS Patients
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome|Ovarian Hyperstimulation Syndrome
Interventions: DRUG: Arvekap 0.1mg (Triptorelin, Ipsen, France)|DRUG: Ganirelix 0.25mg (Orgalutran, Organon, The Netherlands)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Enhance Resilience and Quality of Life of School-aged Children With Autism in Inclusive Education Through Sailing
Status: NOT_YET_RECRUITING
Conditions: Autistic Disorders Spectrum|Child Development|Well-Being, Psychological
Interventions: OTHER: Community-based sailing|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Study to Evaluate the Safety and Efficacy of Lutetium[177Lu] Oxodotreotide Injection in Patients With Advanced Neuroendocrine Neoplasms
Status: NOT_YET_RECRUITING
Conditions: Advanced Neuroendocrine Neoplasm
Interventions: DRUG: Lutetium[177Lu] Oxodotreotide Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smoking by IV Pulsed Nicotine
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Nicotine 0.2mcg/kg/s and 1.0mcg/kg/s
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy of Internet-delivered Trauma-focused CBT for Young People With PTSD
Status: RECRUITING
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Therapist-supported internet-delivered trauma-focused CBT|BEHAVIORAL: 12 weeks of therapist-supported internet-delivered psychoeducation and stress management/relaxation for both the youth and the care giver.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Amoxicillin-Clavulanic Acid 600 mg-42.9 mg/ 5 mL Oral Suspension Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: amoxicillin-clavulanic acid 600 mg- 42.9 mg/ 5 mL oral suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Randomized, Sham-controlled Study of gammaCore ® (nVNS) for Prevention of Episodic Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DEVICE: gammaCore®-R|DEVICE: gammaCore®-R Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Clomiphene Citrate and Gonadotropins in Ovulation Induction Cycles
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: clomiphene citrate|DRUG: gonadotropins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: In Vitro Follicle Activation in Patient With Premature Ovarian Failure Under 36 Years Old
Status: COMPLETED
Conditions: Activation of Primordial Follicles
Interventions: PROCEDURE: In vitro activation of primordial follicles by PTEN inhibitor and AKT stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Effectiveness of Rilonacept (IL-1 Trap) Administered Subcutaneously in Subjects With Non Dialysis-Dependent Chronic Kidney Disease (NDD-CKD) and Anemia
Status: WITHDRAWN
Conditions: Chronic Kidney Disease|Anemia
Interventions: DRUG: Rilonacept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Phase 2 Pharmacokinetic Trial of Chemotherapy With or Without Panitumumab in Patients With Metastatic and/or Recurrent Squamous Cell Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of Head and Neck
Interventions: DRUG: Panitumumab|DRUG: Cisplatin|DRUG: 5FU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Foot Orthoses in Patellofemoral Pain Syndrome: a Prospective Randomized Study of Morpho-specific Versus Placebo Orthoses
Status: UNKNOWN
Conditions: Patellofemoral Pain Syndrome
Interventions: DEVICE: Foot orthoses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vestibular Function Outcome After Cartilage Cap Occlusion Surgery
Status: WITHDRAWN
Conditions: Vestibular Dizziness|Superior Semicircular Canal Dehiscence
Interventions: PROCEDURE: cartilage cap occlusion surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-Discharge Bundle for Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease to Reduce Readmissions
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Exacerbation of Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: Bundle tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Pharmacokinetics of Repaglinide, Metformin and Combination Tablet in Healthy Volunteers
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: repaglinide|DRUG: metformin|DRUG: repaglinide and metformin combination tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AMZ001 for the Treatment of Knee Osteoarthritis Symptoms
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: AMZ001|DRUG: Placebo|DRUG: Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mirror Therapy Rehabilitation of the Upper Limb After Stroke (NEURO-MIROIR 2)
Status: RECRUITING
Conditions: Stroke
Interventions: OTHER: Conventional rehabilitation|DEVICE: Intensive Visual Simulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hysteroscopic Tubal Occlusion With the Use of Iso Amyl-2-cyanoacrylate
Status: UNKNOWN
Conditions: Fallopian Tube Occlusion
Interventions: DRUG: Isoamyl-2-cyanoacrylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Drug Interaction Study Between Erdosteine and Bepotastine Besilate in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Erdos|DRUG: Talion|DRUG: Erdos, Talion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Exploring the Efficacy and Safety of Siponimod in Patients With Secondary Progressive Multiple Sclerosis (EXPAND)
Status: COMPLETED
Conditions: Secondary Progressive Multiple Sclerosis
Interventions: DRUG: BAF312|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Smoking Cessation Medications: Efficacy, Mechanisms and Algorithms
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: DRUG: nicotine patch|DRUG: nicotine lozenge|DRUG: nicotine patch + nicotine lozenge|DRUG: bupropion|DRUG: bupropion + lozenge|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Studying Pain and Symptom Distress in Patients With Advanced Colon Cancer, Rectal Cancer, Pancreatic Cancer, or Liver Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Depression|Fatigue|Liver Cancer|Pain|Pancreatic Cancer
Interventions: OTHER: medical chart review|OTHER: questionnaire administration|OTHER: study of socioeconomic and demographic variables|PROCEDURE: quality-of-life assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Imlunestrant (LY3484356) in Female Participants With Impaired Liver Function
Status: COMPLETED
Conditions: Hepatic Insufficiency|Healthy
Interventions: DRUG: Imlunestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intrathecal Injection of Hyperbaric Bupivacaine Versus a Mixture of Hyperbaric and Isobaric Bupivacaine in Patients Undergoing Lower Abdominal Surgery
Status: COMPLETED
Conditions: Spinal Anesthesia|Hyperbaric Bupivacaine|Isobaric Bupivacaine|Lower Abdominal Surgery
Interventions: DRUG: Group A (hyperbaric bupivacaine)|DRUG: Group B (Mixture of Hyperbaric and Isobaric Bupivacaine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Studying Maintenance Treatment With Lenalidomide and Dexamethasone Versus Lenalidomide, Dexamethasone and MLN9708 After Autologous Hematopoietic Stem Cell Transplantation in Patients With Newly-diagnosed Symptomatic Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: MLN9708|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study)
Status: RECRUITING
Conditions: Cognitively Normal Older Adults|Hypertension|Subjective Cognitive Decline|Family History of Dementia
Interventions: DRUG: Angiotensin II Receptor Blockers (ARBs, losartan) and Calcium Channel Blockers (CCB, amlodipine)|OTHER: PCP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Designed to Evaluate the Safety and Efficacy of Venetoclax Plus Dexamethasone (VenDex) Compared With Pomalidomide Plus Dexamethasone (PomDex) in Participants With t(11;14)-Positive Relapsed or Refractory Multiple Myeloma.
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Pomalidomide|DRUG: Dexamethasone|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cancer Prevention and Treatment Among African American Older Adults: Treatment Trial
Status: COMPLETED
Conditions: Breast Cancer|Colon Cancer|Rectum Cancer|Cervix Cancer|Prostate Cancer|Lung Cancer
Interventions: BEHAVIORAL: Educational materials|BEHAVIORAL: educational materials, plus patient navigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Chamomile Therapy for Anxiety
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: DRUG: Chamomile (Matricaria recutita)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First in Human Study of the Safety, Tolerability and Pharmacokinetics of PRV-002 in Healthy Volunteers
Status: UNKNOWN
Conditions: Traumatic Brain Injury (TBI)
Interventions: DRUG: PRV-002|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SEMS Placement Before Surgery in Unblocking Bile Duct in Patients With Periampullary Pancreatic Cancer With Severe Obstructive Jaundice
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: PROCEDURE: Endoscopic Retrograde Cholangiopancreatography|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: IMPT-514 in Systemic Lupus Erythematosus, Anca-associated Vasculitis, and Idiopathic Inflammatory Myopathy
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus (SLE)|ANCA Associated Vasculitis (AAV)|Idiopathic Inflammatory Myopathy (IIM)
Interventions: DRUG: IMPT-514 CART Cell Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Healthy Living in Overweight and Obese Adolescents ASGE-FABES Program in Development of Formats
Status: COMPLETED
Conditions: Healthy Lifestyle Behaviors|Overweight Adolescents|Obese Adolescents
Interventions: BEHAVIORAL: ASGE-FABES Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effects of 2 Different Duration of Albendazole Therapy in Patients With Neurocysticercosis in Brain ≤ 5 Lesions on CT
Status: COMPLETED
Conditions: Neurocysticercosis
Interventions: DRUG: 7 days of albendazole 15 mg/kg/day|DRUG: 28 days of albendazole 15 mg/kg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Autologous CD19 CAR-T Cells for R/R B-ALL
Status: UNKNOWN
Conditions: Relapsed B Acute Lymphoblastic Leukaemia|Refractory B Acute Lymphoblastic Leukaemia
Interventions: BIOLOGICAL: CD19 CAR-T CELLS|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial of KD018 With Neo-Adjuvant Concurrent Chemo-Radiation Therapy in Patients With Locally Advanced Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DRUG: Chemo with concomitant Capecitabine and KD018
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Remote Ischemic Preconditioning on Elective Percutaneous Coronary Intervention in Diabetic Nephropathy
Status: COMPLETED
Conditions: Contrast Induced Acute Kidney Injury
Interventions: PROCEDURE: Remote ischemic preconditioning|PROCEDURE: Sham ischemic preconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics, Efficacy and Safety of Intravenous Golimumab in Pediatric Participants With Active Polyarticular Course Juvenile Idiopathic Arthritis Despite Methotrexate Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Arthritis, Juvenile
Interventions: DRUG: Golimumab|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CXD101 in Immunotherapy-related Liver Cancer
Status: RECRUITING
Conditions: HCC
Interventions: DRUG: Zabadinostat (CXD101) and Geptanolimab|DRUG: Lenvatinib and Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of PDT, Intravitreal Ranibizumab and Combination for Polypoidal Choroidal Vasculopathy Under 1+PRN Regimen
Status: COMPLETED
Conditions: Polypoidal Choroidal Vasculopathy
Interventions: DRUG: verteporfin|DRUG: verteporfin and ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of CD19/22 CART Cells Combined With PD-1 Inhibitor in Relapsed/Refractory B-cell Lymphoma
Status: UNKNOWN
Conditions: Relapsed Non Hodgkin Lymphoma|Refractory Non-Hodgkin Lymphoma
Interventions: BIOLOGICAL: CD19/22 CART|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Goal-directed MIS Simulation Training With the LTB-Curriculum Prior to First Operations on Patients: Study Protocol for a Multi-centre Randomized Controlled Validation Trial (NOVICE)
Status: UNKNOWN
Conditions: Minimally Invasive Surgery Basic Skills
Interventions: PROCEDURE: LTB-Curriculum|PROCEDURE: Laparoscopic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 1068GCC Evaluate Efficacy & Explore Mechanism of Acupuncture in Treating Bortezomib-induced Peripheral Neuropathy (BIPN) in Multiple Myeloma
Status: COMPLETED
Conditions: Peripheral Neuropathies|Multiple Myeloma
Interventions: DEVICE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A One Year Trial Evaluating the Safety and Efficacy of the ALK House Dust Mite Allergy Tablet
Status: COMPLETED
Conditions: House Dust Mite Allergy
Interventions: BIOLOGICAL: AIT Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Efficacy of Botulax® in Subjects With Benign Masseteric Hypertrophy
Status: COMPLETED
Conditions: Benign Masseteric Hypertrophy
Interventions: DRUG: Botulinum Toxin Type A Injection (Botulax®) 24Units|DRUG: Botulinum Toxin Type A Injection (Botulax®) 48Units|DRUG: Botulinum Toxin Type A Injection (Botulax®) 72Units|DRUG: Botulinum Toxin Type A Injection (Botulax®) 96Units|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of an Online Prevention Program in Reducing the Risk of STD Infection in Young Adults
Status: COMPLETED
Conditions: HIV Infections|Sexually Transmitted Diseases
Interventions: BEHAVIORAL: Youthnet Internet-based program|BEHAVIORAL: Control Internet based program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: To Study the Effects of Co-ingesting Different Forms of Almond, Almond Paste, Fibre, and Almond Phytochemicals With Bread on Postprandial Glucose and Insulin Profiles
Status: COMPLETED
Conditions: Cardiovascular Diseases|Metabolic Disease
Interventions: OTHER: Glucose control|OTHER: Bread control|OTHER: Almond paste|OTHER: Almond paste and inulin|OTHER: Low dose almond paste and inulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neoadjuvant Effect of Albumin Binding Paclitaxel Compared With Common Paclitaxel in Breast Cancer：an Observational Single Center Study of Clinical Efficacy in Adjuvant Chemotherapy
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Taxol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Investigate the Safety, Immunogenicity of Bivalent mRNA Vaccine RQ3027 and RQ3025 as a Booster Dose in Healthy Adults
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: RQ3013|BIOLOGICAL: RQ3025|BIOLOGICAL: RQ3027
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of Autologous Chimeric Switch Receptor Modified T Cells in Recurrent Glioblastoma Multiforme
Status: UNKNOWN
Conditions: Glioblastoma Multiforme
Interventions: BIOLOGICAL: Anti-PD-L1 CSR T cells|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety, Tolerability, and Pharmacokinetics of TPN171H Tablets in Patients With Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: TPN171H
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT