pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT-128800 in Healthy Subjects
Status: COMPLETED
Conditions: Safety and Tolerability
Interventions: DRUG: ACT-128800|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Study of the ETX-4143 2.0 Device in Subjects With Eye Pain
Status: NOT_YET_RECRUITING
Conditions: Eye Pain
Interventions: DEVICE: ETX-4143 2.0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Moderate POstoperative Recurrence in Crohn's Disease: a randoMizEd contROLled Trial of Therapeutic Escalation, the POMEROL Trial. (POMEROL)
Status: UNKNOWN
Conditions: Crohn Disease
Interventions: DRUG: Infliximab CT-P13|DRUG: Immunosuppressors (Thiopurines or Methotrexate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rehabilitating and Decelerating Language Loss in Primary Progressive Aphasia With tDCS Plus Language Therapy
Status: COMPLETED
Conditions: Primary Progressive Aphasia|PPA
Interventions: DEVICE: Active tDCS plus Speech-Language Therapy|DEVICE: Sham tDCS plus Speech-Language Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Patients With Takayasu Arteritis Complicated With Pulmonary Artery Involvement
Status: RECRUITING
Conditions: Takayasu Arteritis With Pulmonary Artery Involvement|Percutaneous Transluminal Pulmonary Angioplasty|PAH Targeted Medication
Interventions: DEVICE: Percutaneous transluminal pulmonary angioplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Determining the Safety of L-serine in ALS
Status: UNKNOWN
Conditions: Amyotrophic Lateral Sclerosis (ALS)
Interventions: DRUG: L-Serine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Barretts oEsophageal Resection With Steroid Therapy Trial
Status: WITHDRAWN
Conditions: Barrett Esophagus|Esophageal Stenosis
Interventions: DRUG: Prednisolone|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Wise App Trial for Improving Health Outcomes in PLWH
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: BEHAVIORAL: Wise app with medication adherence reminders|BEHAVIORAL: Wise app with fitness reminders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Wearable Vibration Device to Prevent Bone Loss in Postmenopausal Women--Aim 2
Status: COMPLETED
Conditions: Osteopenia
Interventions: DEVICE: Wearable vibration belt|DEVICE: Sham, wearing belt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Magrolimab (Hu5F9-G4) in Combination With Cetuximab in Participants With Solid Tumors and Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Solid Tumor|Colorectal Cancer
Interventions: DRUG: Magrolimab|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Understanding How Cigarette Direct Mail Marketing Influences Smoking Behaviors Among High and Low Socioeconomic Status Young Adult Smokers
Status: RECRUITING
Conditions: Nicotine Dependence
Interventions: BEHAVIORAL: Exposure to smoking advertising with coupon|BEHAVIORAL: Exposure to smoking advertising without coupons|BEHAVIORAL: Exposure to non health related images
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: MARSHALL PLAN Vs. Pulmonary Veins Isolation Monocentric Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Destruction of Marshall bundles|PROCEDURE: Pulmonary veins isolation|PROCEDURE: Linear ablation in the left and right atria
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases From Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Male Breast Cancer|Stage IV Breast Cancer|Stage IV Melanoma|Stage IV Non-small Cell Lung Cancer|Stage IV Renal Cell Cancer|Stage IVA Colon Cancer|Stage IVA Rectal Cancer|Stage IVB Colon Cancer|Stage IVB Rectal Cancer|Tumors Metastatic to Brain
Interventions: DRUG: cediranib maleate|RADIATION: whole-brain radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatments for Insomnia in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease|Insomnia
Interventions: DEVICE: Light box (Litebook company)|BEHAVIORAL: CBT and sleep hygiene|DRUG: Doxepin and Zopiclone|DEVICE: Light box ( Litebook company)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect and Safety of Quetiapine Extended Release (XR) (FK949E) in Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: quetiapine extended release (XR)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Snacks Which Vary Nutritionally in Their Satiating Potential on Measures of Appetite Control
Status: COMPLETED
Conditions: Lack of Satiety|Hyperphagia
Interventions: OTHER: Almonds|OTHER: Cheese Savouries
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase I Study of Recombinant Vaccinia Virus That Expresses Prostate Specific Antigen in Adult Patients With Adenocarcinoma of the Prostate
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: BIOLOGICAL: PROSTVAC
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Pulmonary Vein (PV) Imaging by Intracardiac Echography (ICE) After Ablation
Status: RECRUITING
Conditions: Atrial Fibrillation Recurrent
Interventions: DEVICE: Atrial fibrillation ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: GLP1R in Parkinson's Disease
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: Semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Double-blind Study on the Benefit of Spironolactone for Treating Acne of Adult Woman.
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: spironolactone|DRUG: Doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Moderate and Severe Cirrhotic Portal Hypertension Due to HBV With Fuzheng Huayu and Entecavir
Status: UNKNOWN
Conditions: Portal Hypertension
Interventions: DRUG: Entecavir+Carvedilol|DRUG: Entecavir+Carvedilol+ Fuzheng Huayu
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of GLP-1 on Postprandial Glucagon Secretion Independent of The Gastric Emptying Rate
Status: UNKNOWN
Conditions: Type 1 Diabetes
Interventions: DRUG: Liraglutide|DRUG: Exenatide|PROCEDURE: Liquid meal test|OTHER: No drug (Baseline day)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Cultured Mesenchymal Bone Marrow Stromal Cells Secreting Neurotrophic Factors (MSC-NTF), in ALS Patients.
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: BIOLOGICAL: MSC-NTF cells transplantation (IM)|BIOLOGICAL: MSC-NTF cells transplantation (IT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of S-1 and Weekly Docetaxel for Metastatic Gastric Carcinoma
Status: COMPLETED
Conditions: Stomach Neoplasms
Interventions: DRUG: S-1, Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EEG Study of IV Methylphenidate-Induced Emergence From Propofol Sedation
Status: WITHDRAWN
Conditions: Anesthesia
Interventions: DRUG: IV Methylphenidate|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vertistop® D and Vertistop® L in Preventing Recurrence of High-recurrence BPPV
Status: COMPLETED
Conditions: Benign Paroxysmal Positional Vertigo (BPPV)
Interventions: DIETARY_SUPPLEMENT: Vertistop D|DIETARY_SUPPLEMENT: Vertistop L
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 9 Week Extension Study of Asenapine and Olanzapine in Treatment of Mania (P07007)(COMPLETED)
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Asenapine|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Brief Intensive Trauma Treatment for Adolescents With (s)PTSD: a Multi-center RCT
Status: RECRUITING
Conditions: Post-traumatic Stress Disorder
Interventions: BEHAVIORAL: Brief Intensive Trauma Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-biotic Intervention for Acute Stress Management
Status: COMPLETED
Conditions: Stress Response|Mood State|Sleep|Cognition
Interventions: DIETARY_SUPPLEMENT: Post-biotic (Colonic-Delivery capsule)|DIETARY_SUPPLEMENT: Post-biotic (Regular Administration capsule)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: MRI Study of Stomach Volumes and Satiety
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Study test meal 1|DIETARY_SUPPLEMENT: Study test meal 2|DIETARY_SUPPLEMENT: Study test meal 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Abexinostat and Ibrutinib in Diffuse Large B-cell Lymphoma and Mantle Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Diffuse Large B-cell Lymphoma|Mantle Cell Lymphoma
Interventions: DRUG: Abexinostat|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Efficacy of KM-819 in Healthy Adults and Participants With Parkinson's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: KM-819|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PEG-Intron For Chronic Myelogenous Leukemia Patients Unresponsive To Or Intolerant Of Roferon Or Intron
Status: TERMINATED
Conditions: Leukemia, Myeloid, Philadelphia-Positive
Interventions: DRUG: PEG-Intron
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Assessing tOTX015 in Combination With Azacitidine (AZA) or AZA Single Agent in Patients With Newly-diagnosed Acute Myeloid Leukemia (AML) Not Candidate for Standard Intensive Induction Therapy (SIIT)
Status: WITHDRAWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: OTX015|DRUG: Vidaza (azacitidine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GRECCAR 8: Primary Tumor Resection in Rectal Cancer With Unresectable Metastasis
Status: COMPLETED
Conditions: Rectal Adenocarcinoma
Interventions: PROCEDURE: Primary tumor resection + chemotherapy|DRUG: Oxaliplatin/irinotecan + capecitabine, 5-FUI ± bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Follow-Up Study to WV19432, to Evaluate Long Term Post-Treatment Effects of PEGASYS (Peginterferon Alfa-2a(40KD))in Patients With HBeAg Positive Chronic Hepatitis B
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: peginterferon alfa-2a [Pegasys]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Noninvasive Spinal Stimulation in Stroke
Status: RECRUITING
Conditions: Stroke
Interventions: DEVICE: Noninvasive spinal stimulation with gait training|DEVICE: Conventional gait training|OTHER: Healthy control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project Women's Insomnia Sleep Health Equity Study (WISHES)
Status: NOT_YET_RECRUITING
Conditions: Insomnia|Sleep Health|Cardiometabolic Health
Interventions: BEHAVIORAL: Mindfulness-based therapy for insomnia (MBTI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sibutramine-metformin Combination Versus Sibutramine and Metformin Monotherapy in Obese Patients
Status: UNKNOWN
Conditions: Obesity
Interventions: DRUG: Sibutramine-Metformin|DRUG: Sibutramine|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Compliance Feasibility Study for Remote Phase 2 Cardiac Rehabilitation
Status: COMPLETED
Conditions: Referred by Cardiologist for Phase 2 Cardiac Rehabilitation
Interventions: DEVICE: Remote Cardiac Rehab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Barusiban Subcutaneously for Reducing Implantation Failure Due to Uterine Contractions
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Barusiban (FE 200440)|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of Delayed-Type Hypersensitivity (DTH) Reactions to Intradermal HIV Envelope Antigen
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: gp160 Vaccine (Immuno-AG)|BIOLOGICAL: gp160 Vaccine (MicroGeneSys)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of High Intensity Laser Therapy Compared With Ultrasound Therapy on Hemiplegic Shoulder Pain; Randomized Control Trial
Status: UNKNOWN
Conditions: Hemiplegic Shoulder Pain
Interventions: DEVICE: High intensity laser therapy|DEVICE: Ultrasound therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ibuprofen and Acetaminophen Versus Ibuprofen and Acetaminophen Plus Hydrocodone for Analgesia After Cesarean Section
Status: COMPLETED
Conditions: Opioid Use|Pain, Postoperative
Interventions: DRUG: Ibuprofen|DRUG: Acetaminophen|DRUG: Norco
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measure of Microglial Activation in the Brain of Parkinson Disease Patients With PET
Status: UNKNOWN
Conditions: Parkinson's Disease With LRRK2 Mutation|Healthy Controls|Parkinson's Disease Without LRRK2 Mutation
Interventions: RADIATION: PET with the tracer 18F-DPA-714|RADIATION: PET with the tracer 11C-PE2I|OTHER: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Music Therapy With Cancer Affected Children and Their Families
Status: RECRUITING
Conditions: Pediatric Cancer
Interventions: BEHAVIORAL: Interaction-focused Music Therapy with Children and Significant Others (INMUT-KB) (exp. group)|BEHAVIORAL: Music Therapy with Children (MUT-K) (exp. group)|BEHAVIORAL: Interaction-focused Music Therapy with Children and Significant Others (WG-KB) (control group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Enzyme Supplements to Treat Celiac Disease
Status: COMPLETED
Conditions: Celiac Disease|Dermatitis Herpetiformis
Interventions: DRUG: STAN1|DRUG: Placebo enzyme|DRUG: STAN1+gluten
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Immunogenicity and Dose Response of ATH03, a New Vaccine Against the Cholesterol Ester Transfer Protein (CETP)
Status: COMPLETED
Conditions: HDL|Drug Safety
Interventions: BIOLOGICAL: ATH03
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LESS TEP vs. Three Port TEP for Inguinal Hernia Repair
Status: ACTIVE_NOT_RECRUITING
Conditions: Inguinal Hernia
Interventions: PROCEDURE: Standard 3 port TEP|PROCEDURE: LESS TEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effective Means to Address Moderately Malnourished Children
Status: COMPLETED
Conditions: Malnutrition
Interventions: DIETARY_SUPPLEMENT: Food supplementation and nutrition education|BEHAVIORAL: Nutrition education|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomized Controlled Trial of Trauma-awareness Training for Early Childhood Educators
Status: COMPLETED
Conditions: Burnout, Professional
Interventions: BEHAVIORAL: Enhancing Trauma Awareness (Diane Wagenhals, MEd-Lakeside Global Institute)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Surgical Compared to Bronchoscopic Lung Volume Reduction in Patients With Severe Emphysema
Status: RECRUITING
Conditions: Emphysema
Interventions: PROCEDURE: Lung volume reduction surgery|PROCEDURE: Bronchoscopic lung volume reduction with valves
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Treatment of Knee Osteoarthritis With Balanced Buttress Absorbable Spacer
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: balanced buttress absorbable spacer|BIOLOGICAL: total knee arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effect of Dalcetrapib on Artherosclerotic Disease in Patients With Coronary Artery Disease
Status: TERMINATED
Conditions: Cardiovascular Disease
Interventions: DRUG: Dalcetrapib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Effect of Food on the Pharmacokinetics/Pharmacodynamics and Safety of CKD-519(CKD-519 FDI)
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: CKD-519 200mg / Fasting, Standard Meal, High Fat Meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Transition to the Paliperidone Palmitate 3-Month Formulation In Participants With Schizophrenia Previously Stabilized on the Paliperidone Palmitate 1-Month Formulation
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Paliperidone palmitate 3 month formulation (PP3M)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension Study, Pilot, Compassionate Use of Azacitidine 300 mg Film Coated Tablets for Acute Myeloid Leukaemia (AML) Patients
Status: NOT_YET_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploring the Use of myfood24 (an Online Nutritional Assessment Tool) in Clinical Dietetic Practice
Status: COMPLETED
Conditions: Nutritional Disorders|Nutrition Therapy|Food Habits
Interventions: DEVICE: myfood24
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Text Message Engagement Support of Mindfulness Smartphone Applications
Status: COMPLETED
Conditions: Depression|Anxiety
Interventions: BEHAVIORAL: Headspace - Meditation and Mindfulness App|BEHAVIORAL: Stop, Breathe, & Think - Meditation and Mindfulness App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simultaneous Working Length Detection Methods
Status: COMPLETED
Conditions: Irreversible Pulpitis|Root Canal Treatment
Interventions: DEVICE: EWL|DEVICE: SWL|DEVICE: RWL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Insulin Detemir Plus Insulin Aspart Against Insulin Glargine Plus Insulin Aspart as Mealtime Insulin in Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin detemir|DRUG: insulin glargine|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reversal of the Antithrombotic Action of New Oral Anticoagulants
Status: UNKNOWN
Conditions: Thrombosis|Anticoagulant-induced Bleeding|Anticoagulant Overdosage|Hemorrhage
Interventions: DRUG: Rivaroxaban|DRUG: Dabigatran
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Vasomotoric Symptoms Study of a 0.5 mg Estradiol and 2.5 mg Dydrogesterone Combination
Status: COMPLETED
Conditions: Postmenopause
Interventions: DRUG: continuous combined estradiol and dydrogesterone|DRUG: continuous combined estradiol and dydrogesterone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NBF Gingival Gel Application After Impacted Lower Third Molar Surgery
Status: COMPLETED
Conditions: Alveolar Osteitis
Interventions: DRUG: NBF|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Rituximab to That of Calcineurin Inhibitors in Children With Steroid Dependent Nephrotic Syndrome
Status: COMPLETED
Conditions: Nephrotic Syndrome
Interventions: DRUG: Tacrolimus|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expanded Access Program With Nivolumab Therapy for Treatment of Advanced/Metastatic SqNSCLC or Non-SqNSCLC After One Prior Systemic Regimen
Status: NO_LONGER_AVAILABLE
Conditions: Squamous Non-Small Cell Lung Cancer|Non-squamous Non-Small Cell Lung Cancer
Interventions: DRUG: Nivolumab
Study Type: EXPANDED_ACCESS
Clinical trial: TeleQuit Smoking Cessation Program
Status: COMPLETED
Conditions: Smoking
Interventions: PROCEDURE: Proactive outreach to counseling|PROCEDURE: Reactive outreach to counseling|PROCEDURE: Intensive counseling|PROCEDURE: Self-help
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early vs. Late Time Restricted Eating vs. Daily Caloric Restriction
Status: RECRUITING
Conditions: Overweight and Obesity
Interventions: BEHAVIORAL: Early TRE|BEHAVIORAL: Late TRE|BEHAVIORAL: DCR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An IIT Clinical Study to Evaluate the Safety and Efficacy of a Single Intrathecal Injection of RJK002 in Patients With Amyotrophic Lateral Sclerosis (ALS)
Status: NOT_YET_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: RJK002 Intrathecal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Rehabilitation Effect of Exercise Training in Cruciate Ligament Reconstruction Patients.
Status: UNKNOWN
Conditions: ACL Injury|ACL - Anterior Cruciate Ligament Rupture|ACL - Anterior Cruciate Ligament Deficiency
Interventions: OTHER: Resistance or home exercise combined with eccentric exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Two Macrolides, Azithromycin and Erythromycin, for Symptomatic Treatment of Gastroparesis
Status: TERMINATED
Conditions: Gastroparesis
Interventions: DRUG: Erythromycin|DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Platform Study of Neoadjuvant and Adjuvant Immunotherapy for Patients With Resectable Adenocarcinoma of the Pancreas
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Cyclophosphamide|BIOLOGICAL: GVAX pancreatic cancer|DRUG: Nivolumab|DRUG: Urelumab|DRUG: BMS-986253
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kinesio Taping With and Without Exercise Program in Primary Dysmenorrhea
Status: COMPLETED
Conditions: Primary Dysmenorrhea
Interventions: OTHER: kinesio taping with exercises|OTHER: Kinesio taping without exercises|OTHER: Kinesio taping without stretch as control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Application of hUC-MSCs in Treating Acute Lung Injury: a Single Center Prospective Clinical Research
Status: UNKNOWN
Conditions: Acute Lung Injury
Interventions: BIOLOGICAL: human derived umbilical cord derived mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ubrogepant treatmeNt in mIgraine Patients Utilizing mOnoclonal aNtibodies
Status: ACTIVE_NOT_RECRUITING
Conditions: Headache, Migraine
Interventions: DRUG: Ubrogepant 50 MG [Ubrelvy]|DRUG: Ubrogepant 100 MG [Ubrelvy]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Effectiveness and Health Economics of a Novel Portable Non-Pneumatic Active Compression Device (NPCD) for Lymphedema/Phlebolymphedema
Status: RECRUITING
Conditions: Phlebolymphedema|Lymphedema|Chronic Venous Insufficiency
Interventions: DEVICE: Dayspring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adult Attention Deficit Hyperactivity Disorder
Status: COMPLETED
Conditions: Adult Attention Deficit Hyperactivity Disorder
Interventions: DRUG: SEP-225289|DRUG: SEP-225289|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Intravesical Qapzola (Apaziquone) as a Surgical Adjuvant in Participants Undergoing Transurethral Resection of Bladder Tumor (TURBT)
Status: TERMINATED
Conditions: Bladder Cancer
Interventions: DRUG: Qapzola|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of ISIS 681257 (AKCEA-APO(a)-LRx) in Participants With Hyperlipoproteinemia(a) and Cardiovascular Disease
Status: COMPLETED
Conditions: Elevated Lipoprotein(a)|Cardiovascular Disease
Interventions: DRUG: ISIS 681257|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Confirmatory Study of DE-089 Ophthalmic Solution in Patients With Dry Eye
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: 3% DE-089 ophthalmic solution|DRUG: 0.1% sodium hyaluronate ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Orthodontic Treatment in Adolescents With Crowding and Displaced Teeth
Status: ACTIVE_NOT_RECRUITING
Conditions: Crowding, Tooth|Orthodontic
Interventions: DEVICE: Damon self-ligating brackets|DEVICE: Victory self-ligating brackets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bosutinib In Subjects With Renal Impairment
Status: COMPLETED
Conditions: Renal Disease, End-Stage|Renal Insufficiency, Chronic|Renal Insufficiency, Acute
Interventions: DRUG: Bosutinib|DRUG: Bosutinib|DRUG: Bosutinib|DRUG: Bosutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reinforcement of the Impact of a Functional Insulin Therapy Training Course by Telemonotoring With a PDA-phone in Type 1 Diabetic Patients. The TELFIT Study Patients
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: paper support|DEVICE: PDA-phone + telemonitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Massage Therapy and Music Therapy on the Quality of Life of Hospice Patients
Status: COMPLETED
Conditions: Pain|Anxiety|Depression|Quality of Life
Interventions: OTHER: Music Therapy|OTHER: Massage Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Increasing Enteral Protein Intake in Critically Ill Trauma and Surgical Patients
Status: COMPLETED
Conditions: Critical Illness|Malnutrition|Enteral Nutrition|Protein Supplementation
Interventions: DIETARY_SUPPLEMENT: Modular enteral protein - Prosource
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychosexual Educational Partners Program (PEPP)
Status: RECRUITING
Conditions: Breast Cancer|Gynecologic Cancer|Sexual Dysfunction|Partner Communication
Interventions: BEHAVIORAL: Self-Guided PEPP Intervention Workbook|BEHAVIORAL: Self-Guided PEPP Education Workbook
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Reversal of Moderate or Superficial Neuromuscular Blockade Induced by Cisatracurium
Status: COMPLETED
Conditions: Neostigmine|Neuromuscular Blocking Agents|Muscle Weakness
Interventions: DRUG: Reversal of moderate neuromuscular blockade|DRUG: Reversal of superficial neuromuscular blockade|DRUG: Two-step reversal|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Analgesic Efficacy of High Frequency Spinal Cord Stimulation
Status: UNKNOWN
Conditions: Lowback and Leg Pain
Interventions: DEVICE: High frequency spinal cord stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant FOLFIRI Based-chemotherapy After Resection of CLM Responding to Preoperative FOLFIRI
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer|Colorectal Liver Metastases
Interventions: DRUG: Postoperative reintroduction of FOLFIRI based chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of the LEFT Smartwatch App as Sleep Positional Therapy for Nocturnal Gastroesophageal Reflux Symptoms.
Status: RECRUITING
Conditions: Gastroesophageal Reflux|Heartburn
Interventions: DEVICE: LEFT smartwatch app
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile Psychosocial Interventions for MMT Clients
Status: UNKNOWN
Conditions: Opioid Abuse|Substance Abuse
Interventions: BEHAVIORAL: standard treatment|BEHAVIORAL: MTS (Mobile Therapeutic System)|BEHAVIORAL: mobile control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers
Status: ACTIVE_NOT_RECRUITING
Conditions: Cigarette Smoking-Related Carcinoma|Tobacco-Related Carcinoma
Interventions: DRUG: Cigarette|DRUG: Nicotine Replacement|DRUG: Nicotine Replacement|OTHER: Questionnaire Administration|OTHER: Survey Administration|DRUG: Very Low Nicotine Content Cigarette|DEVICE: ECIG-Hi|DEVICE: ECIG-Lo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Nature Based Sounds' Intervention on Agitation and Anxiety of Patients Admitted in Intensive Care Units.
Status: COMPLETED
Conditions: Agitated; State, Acute Reaction to Stress|Anxiety
Interventions: OTHER: Nature based sounds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Paclitaxel for Injection (Albumin-bound) for First-line Chemotherapy of Ovarian Cancer
Status: NOT_YET_RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: Paclitaxel for injection (albumin-bound)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Phase II Study to Evaluate Immunogenicity and Safety of a Single IMVAMUNE Booster Vaccination Two Years After the Last IMVAMUNE Vaccination in Former POX-MVA-005 Vaccinees
Status: COMPLETED
Conditions: Smallpox
Interventions: BIOLOGICAL: IMVAMUNE|BIOLOGICAL: IMVAMUNE|PROCEDURE: Blood Draw Only
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Does Positive Expiratory Pressure Mask Therapy Improve Recovery From Acute Exacerbations of Chronic Obstructive Pulmonary Disease?
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|Lung Diseases, Obstructive
Interventions: DEVICE: Positive expiratory pressure (PEP) mask therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Accurate Dosimetry and Biomarkers Improve Survival in HCC Patients Treated With Resin 90 Yttrium (90Y)-Microspheres
Status: UNKNOWN
Conditions: HCC
Interventions: RADIATION: Personalized dosimetry approach|RADIATION: Standard dosimetry approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Variability of Whole Blood Clotting Time Measurements in Ex Vivo Human Blood Samples Spiked With Anticoagulants
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Blood drawn by direct venipuncture|DRUG: edoxaban|DRUG: Enoxaparin|DRUG: Saline sham
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating the Efficacy of a Gum Health Formulation on Teeth Whitening in Patients With Gingivitis and Periodontitis
Status: COMPLETED
Conditions: Tooth Discoloration|Periodontal Diseases
Interventions: OTHER: Gum health formulation in intra-oral device|OTHER: Gum health formulation on toothbrush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Progressive Muscle Relaxation and Laughter Therapy on Women Undergoing In Vitro Fertilization
Status: COMPLETED
Conditions: Infertility, Female
Interventions: BEHAVIORAL: Progressive muscle relaxation+laughter therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Three Daily Wear Monthly Replacement Silicone Hydrogel Contact Lenses With Two Multi-purpose Disinfecting Solution Combinations
Status: COMPLETED
Conditions: Refractive Errors
Interventions: DEVICE: LID018869+RepleniSH|DEVICE: LID018869+Biotrue|DEVICE: Biofinity+RepleniSH|DEVICE: PV+Biotrue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Everyday Function Intervention Trial
Status: COMPLETED
Conditions: Cognitive Change|Cognitive Impairment|Healthy Aging|Dementia
Interventions: BEHAVIORAL: Cognitive Training|BEHAVIORAL: Cognitive Stimulating Activities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Hypertonic Saline vs. Mannitol for Elevated Intercranial Pressure
Status: TERMINATED
Conditions: Traumatic Brain Injury|Elevated Intracranial Pressure
Interventions: DRUG: Mannitol|DRUG: Hypertonic Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intranasal Civamide for Episodic Cluster Headache
Status: COMPLETED
Conditions: Episodic Cluster Headache
Interventions: DRUG: Civamide (Zucapsaicin)|DRUG: Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Three Formulations of the Candidate Vaccine AMA 1 in Healthy Dutch Adult Volunteers
Status: COMPLETED
Conditions: Plasmodium Falciparum Malaria
Interventions: BIOLOGICAL: PfAMA-1-FVO[25-545]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluating Adjunctive Cryopreserved Amniotic Membrane Treatment in Herpes Simplex Dendritic Keratitis
Status: WITHDRAWN
Conditions: Herpes Simplex Dendritic Keratitis
Interventions: DEVICE: Prokera Slim|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Antithrombin in Cardiac Surgery With Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Acquired Antithrombin III Deficiency|Coronary Artery Bypass
Interventions: DRUG: Antithrombin III
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Impact of Vitamin on the Clinical Course in Cases Infected by Novel H1N1 Influenza Virus A
Status: UNKNOWN
Conditions: H1N1 Influenza
Interventions: DRUG: Vitamin (vitamin A 15 mg,C 500 mg, E 400IU)|DRUG: Placebo (digestive tablet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Physiotherapy in Exacerbation Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Physiotherapy program+medical treatment|OTHER: Medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Antibiotic Treatment of Acute Watery Diarrhea, Rifaximin Versus Azithromycin, With Loperamide Adjunct
Status: RECRUITING
Conditions: Diarrhoea;Acute|Diarrhea Travelers
Interventions: DRUG: Rifaximin 550 MG|DRUG: Azithromycin 500 MG|DRUG: Loperamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Buckwheat and Couscous on Satiety and Food Intake in Young Adults
Status: COMPLETED
Conditions: Food|Eating|Appetite
Interventions: OTHER: Food-1|OTHER: Food-2|OTHER: Food-3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial to Evaluate the Safety and Efficacy of MB-102 in Patients With BPDCN.
Status: TERMINATED
Conditions: Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
Interventions: BIOLOGICAL: MB-102|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TAP Block vs CWI for Total Abdominal Hysterectomy, a RCT
Status: NOT_YET_RECRUITING
Conditions: Postoperative Pain
Interventions: PROCEDURE: Continuous Wound Infusion|PROCEDURE: TAP block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection of Ovarian Cancer Using an Artificial Intelligence Enabled Transvaginal Ultrasound Imaging Algorithm
Status: NOT_YET_RECRUITING
Conditions: Ovarian Cancer
Interventions: DIAGNOSTIC_TEST: Artificial Intelligence Enabled Transvaginal Ultrasound Imaging algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioequivalence Study of Lu AF35700
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lu AF35700 5 mg clinical formulation|DRUG: Lu AF35700 5 mg commercial formulation|DRUG: Lu AF35700 10 mg clinical formulation|DRUG: Lu AF35700 10 mg commercial formulation|DRUG: Lu AF35700 20 mg clinical formulation|DRUG: Lu AF35700 20 mg commercial formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Early Cardiac Rehabilitation of AMI Patients on the Incidence of Post-infarction HF
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: BEHAVIORAL: Cardiac rehabilitation quality improvement system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Efficacy of Resveratrol Containing Mouthwash as Adjunct Treatment Periodontitis:
Status: RECRUITING
Conditions: Periodontitis
Interventions: OTHER: resveratrol mouthwash as adjunct to scaling and root planing in periodontitis patients|OTHER: chlorhexidine mouthwash as adjunct to scaling and root planing in periodontitis patients|OTHER: placebo mouthwash as adjunct to scaling and root planing in periodontitis patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigation of Association Between UGT1A1 Polymorphisms and Irinotecan Toxicity in Korean Patients
Status: UNKNOWN
Conditions: Stage IV Colorectal Cancer|Gastric Cancer
Interventions: DRUG: Irinotecan, 5FU, leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT