pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Needle-Based Confocal Laser Endomicroscopy for Diagnosis of Lung Cancer in Patients With Peripheral Pulmonary Nodules
Status: RECRUITING
Conditions: Lung Carcinoma
Interventions: OTHER: Fluorescein|DEVICE: Image-Guided Needle Confocal Laser Endomicroscopy|PROCEDURE: Ultrasound-Guided Transbronchial Needle Aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Sodium Hyaluronate Ophthalmic Solution, 0.18% for Treatment of Dry Eye Syndrome
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: Sodium Hyaluronate Ophthalmic Solution, 0.18%|OTHER: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TAPB Combined With RSB Versus ESPB for Postoperative Analgesia After Laparoscopic Liver Resection
Status: NOT_YET_RECRUITING
Conditions: Laparoscopic Hepatectomy|Nerve Block
Interventions: PROCEDURE: erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: LEE011 Plus Everolimus in Patients With Metastatic Pancreatic Adenocarcinoma Refractory to Chemotherapy
Status: UNKNOWN
Conditions: Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: LEE011|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Immunogenicity of the Bivalent Killed Whole Cell Oral Cholera Vaccine in Adults and Children
Status: COMPLETED
Conditions: Vibrio Cholerae
Interventions: BIOLOGICAL: killed bivalent (O1 and O139)whole cell oral cholera vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bevacizumab and Letrozole in Treating Postmenopausal Women With Locally Advanced or Metastatic Breast Cancer That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reciprocal Imitation Training and Musical Rhythm Sensitivity in Autistic Toddlers
Status: RECRUITING
Conditions: Autism|Autism Spectrum Disorder
Interventions: BEHAVIORAL: Reciprocal Imitation Training|BEHAVIORAL: music-enhanced Reciprocal Imitation Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of Trastuzumab or Trastuzumab/Pertuzumab to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma
Status: RECRUITING
Conditions: Endometrial Serous Adenocarcinoma|Uterine Corpus Carcinosarcoma
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Carboplatin|PROCEDURE: Computed Tomography|PROCEDURE: Echocardiography|DRUG: Hyaluronidase-zzxf/Pertuzumab/Trastuzumab|PROCEDURE: Multigated Acquisition Scan|DRUG: Paclitaxel|OTHER: Quality-of-Life Assessment|DRUG: Trastuzumab/Hyaluronidase-oysk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hip Denervation in Juvenile Idiopathic Arthritis With Hip Arthritis
Status: COMPLETED
Conditions: Juvenile Idiopathic Arthritis|Hip Arthritis
Interventions: DRUG: Lidocaine|DRUG: Placebo|DRUG: Steroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Blood Pressure and Glucose Lowering for the Prevention of Vascular Disease in High Risk Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Perindopril-indapamide|DRUG: Gliclazide MR-based glucose lowering
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Participation and Executive Functions in Adults Following Traumatic Brain Injury In Sub-Acute Inpatient Rehabilitation
Status: RECRUITING
Conditions: Traumatic Brain Injury
Interventions: OTHER: New treatment protocol|OTHER: Conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Hemostatic Agent (PuraStat®) in Reducing Delayed Bleeding After Endoscopic Submucosal Dissection
Status: RECRUITING
Conditions: Colo-rectal Cancer
Interventions: DEVICE: Endoscopic submucosal dissection with Purastat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Topical Application of MyoRx (Omega 3 Fatty Acids Containing) Cream
Status: COMPLETED
Conditions: Myofacial Pain
Interventions: DRUG: MyoRx Cream (6% Omega 3 Fatty Acid)|DRUG: Placebo cream, no Omega 3 fatty acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cervical Interlaminar Versus Transforaminal Epidural Steroid Injection
Status: WITHDRAWN
Conditions: Cervical Radiculopathy
Interventions: DRUG: Transforaminal Epidural Steroid Injection with Dexamethasone|DRUG: Interlaminar Epidural Steroid Injection with Betamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: SHR-1701 in Combination With Famitinib in Patients With Recurrent/Metastatic Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: SHR-1701|DRUG: Famitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protocol for Comparing the Efficacy of Three Reconstruction Methods of the Digestive Tract After Proximal Gastrectomy
Status: NOT_YET_RECRUITING
Conditions: Proximal Gastric Adenocarcinoma|Gastrectomy|Anastomosis|Reflux Esophagitis|Postoperative Complications
Interventions: PROCEDURE: Kamikawa|PROCEDURE: STJI|PROCEDURE: SOFY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Bacillus Spore Probiotics in Reducing Constipation, Anorexia, and Slow Weight Gain in Children
Status: RECRUITING
Conditions: Constipation|Anorexia|Weight Gain
Interventions: OTHER: RO water|DIETARY_SUPPLEMENT: LiveSpo Preg-Mom|DIETARY_SUPPLEMENT: LiveSpo KIDS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Vitamin D Supplementation on Depression and Inflammatory Markers
Status: COMPLETED
Conditions: Major Depression|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: VTX002 Versus Placebo for the Treatment of Moderately to Severely Active Ulcerative Colitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Colitis, Ulcerative
Interventions: DRUG: VTX002|DRUG: VTX002|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: B/F/TAF vs Atripla Double-Blind Switch Study in HIV-1 Infected Adults
Status: TERMINATED
Conditions: HIV-1-infection
Interventions: DRUG: B/F/TAF|DRUG: Atripla|DRUG: B/F/TAF Placebo|DRUG: Atripla Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A 24-Week Efficacy, Safety and Tolerability of Rivastigmine Patch Study in Patients With Probable Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Rivastigmine Patch|DRUG: Rivastigmine Capsules|DRUG: Placebo to Rivastigmine patch|DRUG: Placebo to Rivastigmine capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of ASLAN001 in Combination With Cisplatin and 5-FU or Cisplatin and Capecitabine
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: ASLAN001|DRUG: cisplatin + capecitabine|DRUG: cisplatin + 5-fluorouracil (or+ Leucovorin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study Assessing a Program of Body Dissatisfaction Psychological Care in Eating Disorders
Status: UNKNOWN
Conditions: Eating Disorders
Interventions: BEHAVIORAL: body dissatisfaction management group|BEHAVIORAL: Relaxation Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study of Influenza Vaccine (Split Virion), Inactivated, Quadrivalent
Status: COMPLETED
Conditions: Seasonal Influenza
Interventions: BIOLOGICAL: Influenza Vaccine (Split Virion), Inactivated, Quadrivalent|BIOLOGICAL: Control Quadrivalent influenza virus vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Dementias and Microbiota Composition: Is Possible to Revert the Dementia Symptoms Reverting the Microbiota Composition?
Status: RECRUITING
Conditions: Dementia Alzheimers|Dementia With Lewy Bodies|Parkinson Disease Dementia|Dementia Frontotemporal|Mild Cognitive Impairment
Interventions: OTHER: No intervention|DIETARY_SUPPLEMENT: Probiotic supplement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Wide Area Circumferential Ablation With Contact Force Versus Cryoballoon Ablation
Status: UNKNOWN
Conditions: Atrial Fibrillation|CryoAblation|Pulmonary Vein Isolation
Interventions: PROCEDURE: Wide area circumferential ablation|PROCEDURE: Cryoballoon ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Get Moving and Get Well - Pilot Study
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Bipolar Disorder|Major Depression|Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: Get Moving and Get Well|BEHAVIORAL: Health and Humor Class
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-Mullerian Hormone - At My Home
Status: COMPLETED
Conditions: Fertility Risk
Interventions: DIAGNOSTIC_TEST: Blood draw through TAP II|DIAGNOSTIC_TEST: Blood draw through ADx cardT|DIAGNOSTIC_TEST: Blood draw through standard venipuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Lower Third Molar Removal With 2% and 4% Articaine
Status: COMPLETED
Conditions: Impacted Third Molar Tooth|Adverse Reaction to Other Local Anesthetics
Interventions: DRUG: Surgery with 2%Articaine first, then Surgery with 4% Articaine|DRUG: Surgery with 4%Articaine first, then Surgery with 2% Articaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Functional Luminal Imaging Probe (FLIP) Topography Use in Patients With Scleroderma and Trouble Swallowing
Status: WITHDRAWN
Conditions: Scleroderma|Dysphagia|GERD - Gastro-Esophageal Reflux Disease
Interventions: DEVICE: FLIP topography|PROCEDURE: Upper Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trebananib in Treating Patients With Persistent or Recurrent Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Adenocarcinoma|Endometrial Adenosquamous Carcinoma|Endometrial Clear Cell Adenocarcinoma|Endometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation|Endometrial Serous Adenocarcinoma|Endometrioid Stromal Sarcoma|Recurrent Uterine Corpus Carcinoma
Interventions: BIOLOGICAL: Trebananib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study to Evaluate the Clinical and Cost-effectiveness of a Culturally Adapted Therapy (C-MAP)
Status: COMPLETED
Conditions: Self Harm
Interventions: BEHAVIORAL: Culturally adapted therapy (C-MAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Lenvatinib Plus Nivolumab in Participants With Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Lenvatinib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supraclavicular Block vs Retroclavicular Block: Incidence of Phrenic Nerve Paralysis
Status: COMPLETED
Conditions: Phrenic Nerve Paralysis
Interventions: PROCEDURE: Supraclavicular vs Retroclavicular Nerve Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimization of Surgical Treatment of Patients With Incisional Ventral Hernias
Status: RECRUITING
Conditions: Incisional Hernia|Medial Hernia|Medial-lateral Hernia
Interventions: PROCEDURE: A new method of repair of the abdominal wall of mid-lateral postoperative ventral hernias
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observation or Radiation Therapy in Treating Patients With Grade I, Grade II, or Grade III Meningioma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: RADIATION: 54 Gy radiotherapy|RADIATION: 60 Gy radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebellar rTMS in Patients With Multiple Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Patients With Multiple Sclerosis
Interventions: DEVICE: High frequency repetitive transcranial magnetic stimulation|DEVICE: Sham repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Elution Swab (ESwab) and Amies Transport Swabs for Screening Patients for Methicillin Resistant Staphylococcus Aureus (MRSA) and Vancomycin Resistant Enterococci (VRE) Colonization
Status: COMPLETED
Conditions: Eluted Swab
Interventions: DEVICE: Eluted Swab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intraperitoneal Ropivacaine Nebulization for Pain Control After Gynecologic Laparoscopic Surgery
Status: COMPLETED
Conditions: Ovarian Cysts
Interventions: DRUG: Ropivacaine nebulization|DRUG: Ropivacaine instillation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Mosunetuzumab Plus Lenalidomide Compared to Anti-CD20 Anti-body + Chemotherapy in Follicular Lymphoma FLIPI2-5
Status: RECRUITING
Conditions: Follicular Lymphoma
Interventions: DRUG: Mosunetuzumab|DRUG: Lenalidomide|DRUG: Rituximab|DRUG: Obinutuzumab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristin|DRUG: Prednisone|DRUG: Rituximab|DRUG: Obinutuzumab|DRUG: Bendamustin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Home-Embedded Palliative Care for Hemodialysis-Dependent End-Stage Renal Disease
Status: COMPLETED
Conditions: End-Stage Renal Disease
Interventions: BEHAVIORAL: Nudge for PHPC Referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD) Study of M5049 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: M5049|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Rediscovering Biomarkers for the Diagnosis and Early Treatment Response in NEN (REBORN)
Status: RECRUITING
Conditions: Neuroendocrine Tumors|Neuroendocrine Neoplasm|Neuroendocrine Tumor Grade 1|Neuroendocrine Tumor Grade 2|Neuroendocrine Carcinoma
Interventions: DRUG: Somatostatin analog; chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Zinc Absorption From Zinc Biofortified Rice
Status: COMPLETED
Conditions: Malnourished Children
Interventions: OTHER: Diet-ZnBfR|OTHER: Diet- CR|OTHER: Diet-ZnBfR|OTHER: CR + Zn
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: GTS21-201 for Alzheimer Disease:GTS-21 Administered Daily for 28 Days to Participants With Probable Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: DMXB-A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study Combining ABT-888, Oral PARP Inhibitor, With Temozolomide in Patients With Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: ABT-888|DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Astym Treatment For de Quervain's Tenosynovitis
Status: COMPLETED
Conditions: de Quervain's Disease
Interventions: OTHER: Occupational therapy|DEVICE: Occupational therapy with ASTYM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EFficacy and Impact on Function of Two Different Doses of Nab-paclitaxEl in Elderly With advanCed breasT Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telehealth in the Rehabilitation of Urinary Incontinence in Older Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Urinary Incontinence in Old Age
Interventions: OTHER: Pelvic physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture on Anxiety and Inflammatory Events Following Surgery of Mandibular Third Molars
Status: COMPLETED
Conditions: Tooth Extraction|Molar, Third|Pain, Postoperative|Trismus|Edema|Anxiety
Interventions: PROCEDURE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Placebo-Controlled Clinical Nutrition Study of the Safety and Metabolic Effects of Two Medical Foods in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: WB-010|OTHER: WB-011|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Carboplatin, Bevacizumab and Pemetrexed in Advanced Non Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Carboplatin, Pemetrexed and Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Laser-assisted Zona Thinning on the Implantation Rate in the Women of Advanced Age
Status: UNKNOWN
Conditions: Female Urogenital Diseases
Interventions: DEVICE: ZILOS-TK IVOS Analyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects and Mechanisms of RAS Training on Upper-limb Movements in PD Patients
Status: NOT_YET_RECRUITING
Conditions: Acoustic Stimulation|Parkinson Disease|Electroencephalography
Interventions: BEHAVIORAL: Upper-limb training involving RAS|BEHAVIORAL: Upper-limb training without the aid of RAS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study Evaluating ZEN003365 in Relapsed/Refractory Lymphoproliferative Malignancies or Relapsed/Refractory AML
Status: WITHDRAWN
Conditions: Lymphoproliferative Malignancies|Acute Myeloid Leukemia
Interventions: DRUG: ZEN003365
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 4 Week Study With BI 144807 in Patients >= 50 Years With Wet Age Related Macular Degeneration
Status: COMPLETED
Conditions: Wet Macular Degeneration
Interventions: DRUG: BI 144807
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Restore Claims Characterization Study
Status: COMPLETED
Conditions: Chronic Refractory Pain Associated With Failed Back Surgery Syndrome, Epidural Fibrosis, Peripheral Causalgia, Complex Regional Pain Syndrome
Interventions: DEVICE: Spinal Cord Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Regulation of Endogenous Glucose Production by Brain Insulin Action in Insulin Resistance
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: DRUG: Intranasal insulin|DRUG: Intranasal placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Efficacy and Safety of OTX-TIC (Travoprost) Intracameral Implant for Patients With Open-angle Glaucoma (OAG) or Ocular Hypertension (OHT)
Status: ACTIVE_NOT_RECRUITING
Conditions: Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: OTX-TIC low dose Travoprost Intracameral Implant|DRUG: OTX-TIC high dose Travoprost Intracameral Implant|DRUG: Durysta, Bimatoprost Intracameral Implant 10 µg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy and Safety of PF-04965842 With or Without Topical Medications in Subjects Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Dermatitis, Atopic
Interventions: DRUG: Abrocitinib 100 mg|DRUG: Abrocitinib 200 mg|DRUG: Placebo|DRUG: Abrocitinib 100 mg|DRUG: Abrocitinib 100 mg|DRUG: Abrocitinib 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: POCUS: Hemostatic Potential and Joint Health in Patients With Severe Hemophilia A on Novel Replacement Therapies
Status: RECRUITING
Conditions: Hemophilia A|Factor VIII
Interventions: DRUG: Eloctate|DRUG: Adynovate|DRUG: Emicizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Vicodin® CR and NORCO® to Placebo in Subjects With Acute Pain Following Bunionectomy
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Hydrocodone/Acetaminophen Extended-Release|DRUG: Hydrocodone/Acetaminophen Immediate Release (NORCO®)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Satavaptan Dose-Ranging Study in Hyponatraemic Patients With Cirrhotic Ascites
Status: COMPLETED
Conditions: Ascites|Liver Cirrhosis
Interventions: DRUG: satavaptan (SR121463B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and PK Parameters of Sodium Nitrite Inhalation Solution in Healthy Subjects
Status: COMPLETED
Conditions: Pulmonary Hypertension|Pulmonary Arterial Hypertension
Interventions: DRUG: 15 mg sodium nitrite inhalation solution|DRUG: 90 mg sodium nitrite inhalation solution|DRUG: 45 mg sodium nitrite inhalation solution|DRUG: 120 mg sodium nitrite inhalation solution|DRUG: 25% MTD sodium nitrite inhalation solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Diagnosis and Treatment Optimization Study of Depression Based on the Neurological Mechanism of Reward System
Status: UNKNOWN
Conditions: Diagnosis and Treatment of Depression
Interventions: DRUG: Escitalopram|DRUG: Duloxetine|DRUG: Mirtazapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supplemental Postoperative Oxygen and Wound Infection in Morbidly Obese Patients
Status: TERMINATED
Conditions: Surgical Wound Infection
Interventions: OTHER: 80% oxygen|OTHER: 30% oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of BMS-986224 in Healthy Subjects and Heart Failure Patients With Reduced Ejection Fraction
Status: TERMINATED
Conditions: Heart Failure
Interventions: DRUG: Placebo|DRUG: BMS-986224
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mini-PNL, RIRS, and ESWL for Treatment of Medium-Sized, High-Density, Non-Lower Pole, Renal Stones
Status: RECRUITING
Conditions: Renal Stone|Percutaneous Nephrolithotomy|Retrograde Intrarenal Surgery|Extracorporeal Shockwave Lithotripsy
Interventions: PROCEDURE: mini-PNL|PROCEDURE: RIRS|PROCEDURE: SWL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid Versus Slow Ingestion of Mixed Meal: Influence on Islet and Incretin Hormone Secretion in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers Recruited From the General Population
Interventions: OTHER: Mixed meal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Imaging Study of XERECEPT® Treatment for Peritumoral Brain Edema (PBE)
Status: TERMINATED
Conditions: Peritumoral Brain Edema|PRIMARY MALIGNANT and METASTATIC BRAIN TUMORS
Interventions: DRUG: Xerecept
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychotherapy for Ketamine's Enhanced Durability in Chronic Neuropathic Pain: A Randomized Controlled Pilot Trial
Status: RECRUITING
Conditions: Neuropathic Pain
Interventions: DRUG: Ketamine Hydrochloride|BEHAVIORAL: Cognitive Behavioral Therapy|OTHER: Ketamine + Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort
Status: NOT_YET_RECRUITING
Conditions: Fatigue Syndrome, Chronic
Interventions: DEVICE: Thermal Pain Stimulation|DEVICE: Physical Effort Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immunological Response After Shrimp Oral Immunotherapy Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Allergy to Shrimp|Immunotherapy
Interventions: OTHER: shrimp allergy with intend to eat shrimp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Strategy for Stage IV Gastric Cancer With Positive Peritoneal Cytology as the Only Non-curable Factor
Status: UNKNOWN
Conditions: Stomach Neoplasm
Interventions: PROCEDURE: standard gastrectomy with D2 lymphadenectomy|PROCEDURE: hyperthermic intraperitoneal chemotherapy|PROCEDURE: Extensive intraperitoneal lavage|OTHER: Preoperative chemotherapy|OTHER: Postoperative chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigational Study of Experimental Medication BMS-986165 in Participants With Moderate to Severe Crohn's Disease
Status: TERMINATED
Conditions: Granulomatous Colitis|Crohn's Disease|Crohn's Enteritis|Granulomatous Enteritis
Interventions: DRUG: BMS-986165|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perianal Nerval Block in Proctological Interventions
Status: COMPLETED
Conditions: Perianal Fistula|Fissure in Ano|Hemorrhoids
Interventions: DRUG: Placebo 40 mL Saline 0.9%|DRUG: 40 mL Ropivacain 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of a New Combination and Schedule of Chemotherapy Drugs for the Treatment of Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: Docetaxel|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of 3D Scanner to Measure Physical Size in Patients With Severe Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy, Spastic
Interventions: DEVICE: Application of 3D scanner to measure physical size in patients with severe cerebral palsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Rogaratinib in Patients With Advanced Pretreated Squamous-cell Non-small Cell Lung Cancer (SQCLC)
Status: TERMINATED
Conditions: Squamous-cell Non-small Cell Lung Cancer
Interventions: DRUG: Rogaratinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD19 Redirected Autologous T Cells for Hodgkin Lymphoma
Status: TERMINATED
Conditions: Hodgkin Lymphoma With no Available Curative Treatment Options Who Have a Limited Prognosis
Interventions: BIOLOGICAL: RNA anti-CD19 CAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Validation of the Client Centered Occupational Therapy Service Model
Status: COMPLETED
Conditions: Occupational Therapy|Psychiatric Rehabilitation
Interventions: BEHAVIORAL: Occupational therapy based on the MOHO theory|BEHAVIORAL: Occupational therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Primary Congenital Glaucoma at Asyut University Hospital
Status: UNKNOWN
Conditions: Primary Congenital Glaucoma
Interventions: PROCEDURE: Combined trabeculotomy-trabeculectomy with mitomycin C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Polyvinylpyrrolidone Iodine on Postoperative Trismus and Swelling During Impacted Third Molar Surgery
Status: COMPLETED
Conditions: Impacted Third Molar Tooth
Interventions: PROCEDURE: Control|PROCEDURE: 0.5% concentration of PVP-I|PROCEDURE: 1 % concentration of PVP-I|PROCEDURE: 3 % concentration of PVP-I
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Nivolumab With Ipilimumab in Participants With Untreated Advanced Kidney Cancer Conducted in India
Status: COMPLETED
Conditions: Kidney Neoplasms
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Uterine Artery Blood Flow in Pregnant Women With PCOS Treated With Metformin
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Exogenous Ketone Ester in Women With Polycystic Ovary Syndrome.
Status: RECRUITING
Conditions: PCOS
Interventions: DIETARY_SUPPLEMENT: 3-OHB (KE4)|DIETARY_SUPPLEMENT: water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GTP Regimen in the Treatment of Refractory/Recurrent HLH
Status: NOT_YET_RECRUITING
Conditions: Refractory|Recurrence|Hemophagocytic Lymphohistiocytosis
Interventions: DRUG: GTP regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylaxis In Venous Thromboembolism In Primary Care, A Pilot Study
Status: TERMINATED
Conditions: Thromboembolism|Deep Vein Thrombosis|Dalteparin
Interventions: DRUG: Dalteparin sodium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: talazoparib plus enzalutamide|DRUG: Placebo plus enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Progressive Lens Designs
Status: COMPLETED
Conditions: Presbyopia
Interventions: DEVICE: Progressive Additional Lenses (PAL), pre calibrated and made of polymeric material with anti-reflection coating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study of the Safety and Pharmacokinetics of Olaratumab (IMC-3G3) in Japanese Participants With Solid Tumors
Status: COMPLETED
Conditions: Malignancy|Metastasis
Interventions: BIOLOGICAL: Olaratumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMA910 Plus GM-CSF With Low-dose Cyclophosphamide Pre-treatment in Advanced Colorectal Carcinoma Patients Following a Successful 12 Week First-line Treatment With Oxaliplatin-based Chemotherapy (IMA910-101)
Status: COMPLETED
Conditions: Colorectal Carcinoma
Interventions: DRUG: Endoxana, Leukine, IMA910|DRUG: Endoxana, Leukine, IMA910, Aldara
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Burden of Disease Study In Patients With Transthyretin Familial Amyloidosis Polyneuropathy (TTR-FAP) orTransthyretin Cardiomyopathy (TTR-CM) And Caregivers
Status: COMPLETED
Conditions: Transthyretin Familial Amyloidosis Polyneuropathy (TTR-FAP)|Transthyretin Cardiomyopathy (TTR-CM)|Familial Amyloid Cardiomyopathy|Senile Systemic Amyloidosis (SSA)
Interventions: OTHER: No drug|OTHER: No drug
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Stop Ovarian Cancer Young; Effect of the Opportunistic Salpingectomy on Age of Menopause
Status: ENROLLING_BY_INVITATION
Conditions: Salpingectomy|Tubal Ligation|Menopause
Interventions: PROCEDURE: Opportunistic salpingectomy / bilateral salpingectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase II Study of Neoadjuvant Weekly Paclitaxel and Carboplatin Followed by Dose Dense Epirubicin and Cyclophosphamide in Stage II and III Triple Negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Paclitaxel|DRUG: Carboplatinum|DRUG: Epirubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Masseter Manual Therapy on Temporomandibular Dysfunction
Status: UNKNOWN
Conditions: Temporomandibular Joint|Temporomandibular Joint Dysfunction Syndrome|Temporomandibular Joint Disorder
Interventions: PROCEDURE: Active release techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vascular Responses to Sympathetic Activation and Altered Shear Rate: The Impact of Hypertension and Sodium Intake
Status: COMPLETED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: Salt Pills|DIETARY_SUPPLEMENT: Placebo Pills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Safety, Tolerability, And Pharmacokinetic Trial With CVX-241 In Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Advanced Solid Tumors
Interventions: DRUG: CVX-241|DRUG: CVX-241|DRUG: CVX-241|DRUG: CVX-241|DRUG: CVX-241|DRUG: CVX-241|DRUG: CVX-241|DRUG: CVX-241
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence and Characterization of Pain in RASopathies
Status: RECRUITING
Conditions: RASopathy|Costello Syndrome|Cardio-Facio-Cutaneous Syndrome|Noonan Syndrome
Interventions: DIAGNOSTIC_TEST: Characterization of pain
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Adaptation of the PCIP for Spanish Speaking Adolescents and Families
Status: SUSPENDED
Conditions: Post-Traumatic Stress Disorder in Adolescence|Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: Primary Care Intervention for PTSD Spanish Speaking Adolescents|BEHAVIORAL: Waitlist Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Pharmacokinetic Study of TAK-285 in Patients With Advanced Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: TAK-285 Dose Escalation Cohorts|DRUG: TAK-285 Recommended Phase 2 Dosing Cohort
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PBMC (Peripheral Blood Mononuclear Cells) /Lymphocyte SPECT (Single Photon Emission Computerized Tomography) Imaging in Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: OTHER: Labeling Ceretec
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Intravenous Lacosamide Compared With Fosphenytoin in the Treatment of Patients With Frequent Nonconvulsive Seizures
Status: COMPLETED
Conditions: Nonconvulsive Seizures
Interventions: DRUG: fPHT|DRUG: LCM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating an Innovative HIV Self-testing Service With Counseling Provided by a Chatbot
Status: NOT_YET_RECRUITING
Conditions: Behaviors, Health
Interventions: BEHAVIORAL: HIVST-Chatbot (HIV self-testing services with counseling provided by a Chatbot)|BEHAVIORAL: HIVST-OIC (HIV self-testing services with counseling provided by administrators)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pioglitazone Attenuates Dysmetabolism in Peritoneal Dialysis (PD) Patients
Status: COMPLETED
Conditions: Peritoneal Dialysis|Pioglitazone|Hypertriglyceridemia|Insulin Resistance|Inflammation
Interventions: DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-world Effectiveness and Cost-effectiveness of HFA-beclometasone Compared With ICS/LABA Combination Therapy
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Extra-fine hydrofluoroalkane-beclometasone dipropionate|DRUG: ICS / LABA via separate pMDI and / or BAI inhalers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ozurdex Versus Ranibizumab Versus Combination for Central Retinal Vein Occlusion
Status: UNKNOWN
Conditions: Macular Edema|Central Retinal Vein Occlusion
Interventions: DRUG: Ozurdex|DRUG: Ranibizumab|DRUG: Combination Ozurdex with Ranibizumab PRN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Plasma 5hmC Signatures as a Marker of Colorectal / Appendiceal Peritoneal Metastasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer Stage IV|Colorectal Cancer Metastatic|Colorectal Cancer, Genetics of|Appendix Cancer
Interventions: DIAGNOSTIC_TEST: prospective single arm biomarker (plasma cell-free DNA hydroxymethylation) study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Naltrexone and/or Ondansetron to Reduce Craving for Alcohol and Drinking
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: naltrexone (up to 50 mg/day) for 8 days; ondansetron (0.25 mg twice a day) for 8 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Durvalumab and Lenvatinib in Participants With Locally Advanced and Metastatic Hepatocellular Carcinoma ( Dulect2020-1 )
Status: RECRUITING
Conditions: Liver Carcinoma|Liver Transplant; Complications
Interventions: DRUG: Durvalumab Injection|DRUG: Lenvatinib 4 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Immunogenic Response of CV-MG01 in Patients With Myasthenia Gravis
Status: COMPLETED
Conditions: Myasthenia Gravis
Interventions: BIOLOGICAL: CV-MG01|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Erlotinib in the Treatment of Patients With Carcinoma of Unknown Primary Site
Status: COMPLETED
Conditions: Neoplasms, Unknown Primary
Interventions: DRUG: Bevacizumab|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of BLI5100 in Patients With Non-Erosive Reflux Disease
Status: COMPLETED
Conditions: Non-erosive Reflux Disease
Interventions: DRUG: BLI5100|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Hyoscine-N-butylbromide (HBB, Buscopan) in Augmented Labour Among Primigravidae
Status: COMPLETED
Conditions: Labor Long
Interventions: DRUG: Hyoscine Butylbromide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of Two Guidance Techniques (Standard Injected CT vs Porto-scanner With Angio-CT) for Thermoablation Treatment of Colorectal Cancer Liver Metastases
Status: RECRUITING
Conditions: Colorectal Cancer Metastatic
Interventions: PROCEDURE: Thermoablation with standard CT guidance|PROCEDURE: Thermoablation with porto-scanner guidance with Angio-CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of a Recombinant DNA-based Hyaluronidase to Dissolve Fixed Amounts of Hyaluronic Acid Dermal Fillers
Status: COMPLETED
Conditions: Dermal Filler
Interventions: DRUG: Hylenex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anxiety Control by Erythrina Mulungu
Status: COMPLETED
Conditions: Dental Anxiety|Impacted Third Molar Tooth
Interventions: DRUG: Mulungu|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT