pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Is Intraperitoneal Drainage Necessary Following Distal Pancreatectomy?
Status: RECRUITING
Conditions: Cyst of Pancreas|Pancreatectomy|Pancreas Neoplasm
Interventions: DEVICE: 19 French Blake Drain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Objective Results of Anterior Cruciate Ligament Reconstruction With and Without Internal Suture Augmentation Technique
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injuries
Interventions: PROCEDURE: all- inside anterior cruciate ligament reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction Chemotherapy Followed by Concurrent Radiation With Cetuximab or Cisplatin in Locally Advanced Nasopharyngeal Cancer
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Cetuximab|DRUG: Cisplatin|DRUG: Docetaxel|RADIATION: Intensity-modulated radiotherapy|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Compare Lasotronix Alone or in Combination With CPP-ACP to Treat DH
Status: RECRUITING
Conditions: Dentin Sensitivity|Hypersensitivity|Cervical Lesion
Interventions: OTHER: Active comparator|DEVICE: Experimental group|COMBINATION_PRODUCT: Combination of laser and paste|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of a Prediction Model for Delirium After Cardiac Surgery Using a Novel Self-Administered Preoperative Cognitive Assessment Tool
Status: RECRUITING
Conditions: Postoperative Delirium|Postoperative Cognitive Dysfunction|Cognitive Decline|Cognitive Impairment|Cognition Disorders|Cardiac Surgery
Interventions: OTHER: CogCheck
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety and Biomarker Effects of RO7269162 in Participants at Risk for or at the Prodromal Stage of Alzheimer's Disease (AD)
Status: RECRUITING
Conditions: Alzheimer's Disease
Interventions: DRUG: RO7269162|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Non-essential Amino Acids on Protein Requirements for Endurance Athletes
Status: COMPLETED
Conditions: Increased Metabolic Requirement|Healthy
Interventions: DIETARY_SUPPLEMENT: BASE egg protein|DIETARY_SUPPLEMENT: BCAA-enriched egg protein|DIETARY_SUPPLEMENT: small amount of essential amino acids|DIETARY_SUPPLEMENT: large amount of essential amino acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Phototherapy by Low-level Light-emitting Diode Therapy (LEDT) on Clinical, Biochemical, Biomechanical, Histologic and Genetic Responses of Muscle Performance of Young Males Submitted to Physical Strength Training
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Effective light-emitting diode therapy|DEVICE: Placebo light-emitting diode therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Monoclonal Antibody Ch14.18, Sargramostim, Aldesleukin, and Isotretinoin After Autologous Stem Cell Transplant in Treating Patients With Neuroblastoma
Status: COMPLETED
Conditions: High Risk Neuroblastoma
Interventions: BIOLOGICAL: Aldesleukin|OTHER: Diagnostic Laboratory Biomarker Analysis|BIOLOGICAL: Dinutuximab|DRUG: Isotretinoin|BIOLOGICAL: Sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cost-utility and Physiological Effects of ACT and BATD in Patients With Chronic Pain and Depression
Status: COMPLETED
Conditions: Randomized Controlled Trial
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy (ACT)|BEHAVIORAL: Behavioral Activation Therapy for Depression (BATD)|OTHER: Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Evaluate Safety and Efficacy of Abiraterone in Participants With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Abiraterone|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Upper Extremity Immobilization and Use of a Steering Wheel Spinner Knob Following Distal Radius Fracture
Status: COMPLETED
Conditions: Distal Radius Fracture
Interventions: OTHER: Spinner knob|OTHER: No Knob
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Isoflurane Versus Propofol for Removal of LMA in Children
Status: COMPLETED
Conditions: Complication of Anesthesia
Interventions: DRUG: comparison of group-I (low dose propofol with isoflurane)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Dental Hygiene Aids in Reducing Gingival Bleeding and Plaque Among Orthodontic Patients.
Status: COMPLETED
Conditions: Gingival Bleeding|Dental Plaque
Interventions: DEVICE: water pik|DEVICE: Super floss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of a Letter Intervention Promoting a Plant-based Diet
Status: COMPLETED
Conditions: Cardiovascular Diseases|Diabetes Mellitus|Obesity
Interventions: BEHAVIORAL: Personal testimonial|BEHAVIORAL: Forks Over Knives Documentary|BEHAVIORAL: Commitment nudge|BEHAVIORAL: Prevention nudge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Manual Therapy on Non Specific Neck Pain
Status: COMPLETED
Conditions: Neck Pain
Interventions: OTHER: Mulligan Reverse Natural Apophysial Glide Technique (RNAGS)|OTHER: Conventional physical therapy and sham manual therapy|OTHER: Conventional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Pinless-Navigated Versus Conventional Total Knee Arthroplasty
Status: COMPLETED
Conditions: Arthropathy of Knee
Interventions: PROCEDURE: Pinless-Navigated Total Knee Arthroplasty|PROCEDURE: Conventional Total Knee Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Mechanism of Jing Si Herbal Tea Liquid Packets and Traditional Western Medicine for Psoriasis
Status: UNKNOWN
Conditions: DLQI|PHQ-9|PSAI|Serum Cytokine Survey
Interventions: COMBINATION_PRODUCT: Jing Si herbal tea liquid packets use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Diagnosis of Structural Sacroiliitis in Patients With Suspicion of Spondyloarthritis (EchoSPA)
Status: UNKNOWN
Conditions: Structural Sacro-iliitis
Interventions: OTHER: pelvic radiography|OTHER: pelvic MRI|OTHER: pelvic CT-scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Single and Multiple Ascending Dose Study of TD-8236 by Inhalation
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: TD-8236|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intermittent and Maintenance of Erlotinib in Combination With Pemetrexed/Carboplatin in Ⅲb/IV Non Small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Mutation
Status: UNKNOWN
Conditions: Lung, Carcinoma
Interventions: DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Yttrium Y 90 Glass Microspheres, Atezolizumab, and Cabozantinib for the Treatment of Unresectable or Locally Advanced Hepatocellular Carcinoma
Status: WITHDRAWN
Conditions: BCLC Stage B Hepatocellular Carcinoma|BCLC Stage C Hepatocellular Carcinoma|Locally Advanced Hepatocellular Carcinoma|Recurrent Hepatocellular Carcinoma|Unresectable Hepatocellular Carcinoma
Interventions: BIOLOGICAL: Atezolizumab|PROCEDURE: Biopsy|DRUG: Cabozantinib S-malate|RADIATION: Yttrium Y 90 Glass Microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Relationship Between Psychosocial Factors Affecting Pain Perception and Physical Activity Level in Pregnant Women With Lumbopelvic Pain
Status: COMPLETED
Conditions: Investigate the Relationship Between the Psychosocial Factors Affecting Pain Perception and Physical Activity Levels in Pregnant Women With Lumbopelvic Pain
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Drug Penetration Into Bone After Repeated Oral Administration of Debio 1450 to Patients Undergoing Hip Replacement Surgery
Status: COMPLETED
Conditions: Bone Diseases, Infectious
Interventions: DRUG: Debio 1450
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Molecular Weight Heparin in Pregnancies With Unexplained Stillbirths
Status: COMPLETED
Conditions: Unexplained Stillbirth
Interventions: DRUG: Bemiparin|OTHER: multivitamins and routine antenatal follow up
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Renal Sympathetic Denervation in Patients With Chronic Kidney Disease and Resistant Hypertension
Status: UNKNOWN
Conditions: Chronic Kidney Disease
Interventions: PROCEDURE: RSD|DRUG: medicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Cardiovascular and Sleep Quality Parameters Under Eurythmy Therapy and Tai Chi in Comparison to Standard Care - A Substudy of the ENTAiER Trial
Status: COMPLETED
Conditions: Fall Patients|Elderly Patients|Chronic Disease|Sleep Quality|Cardiovascular System|Tai Chi|Eurythmy Therapy
Interventions: OTHER: This is an observational study being conducted as a substudy of another trial.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nivolumab for the Reversal of Squamous Dysplasia in High Risk Current and Former Smokers
Status: ACTIVE_NOT_RECRUITING
Conditions: Bronchial Dysplasia|Tobacco Smoking|History of Non-Small Cell Lung Cancer|History of Head and Neck Cancer
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Camptothecin-20-O-Propionate Hydrate (CZ48)
Status: UNKNOWN
Conditions: Malignant Lymphoma of Extranodal and/or Solid Organ Site|Solid Tumor
Interventions: DRUG: CZ48
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Transcutaneous Electrical Nerve Stimulation and Manual Therapy in Children With Cerebral Palsy
Status: COMPLETED
Conditions: Bladder Dysfunction|Bowel Dysfunction|Cerebral Palsy|Neurogenic Bladder|Neurogenic Bowel
Interventions: DEVICE: TENS|OTHER: Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose-response Study Examining the Contribution of GLP-1 Receptor Signaling to Glucagon-stimulated Insulin Secretion
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Exendin-9,39|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial of CORT108297 to Attenuate the Effects of Acute Stress in the Allocortex (CORT-X)
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Alzheimer Disease|Memory Impairment
Interventions: DRUG: CORT108297|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Bladder Dysfunction in Acute Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries|Urinary Bladder, Overactive
Interventions: DRUG: Onabotulinumtoxin A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Central and Peripheral Changes in Quadriceps Femoris Function After Different Types of Isometric Strength Training
Status: COMPLETED
Conditions: Quadriceps Muscle Function
Interventions: OTHER: Isometric training with electromyostimulation|OTHER: Isometric training with voluntary activation|OTHER: Isometric training with combination of electromyostimulation and voluntary activation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lactoferrin Supplementation and Iron Metabolism in Healthy Pregnant Women
Status: UNKNOWN
Conditions: Iron-deficiency Anemia
Interventions: DIETARY_SUPPLEMENT: lactoferrin-supplemented formula|DIETARY_SUPPLEMENT: formula without lactoferrin supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects Of Kinesio Taping On Balance, Functionality, And Participation In Children With Cerebral Palsy?
Status: COMPLETED
Conditions: Cerebral Palsy, Spastic|Gait Disorders, Neurologic|Hemiplegic Cerebral Palsy
Interventions: OTHER: Kİnesio Taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Intraarticular IL1-Ra on Pain and Inflammatory Mediators After Knee Arhroscopy
Status: WITHDRAWN
Conditions: Knee Injuries
Interventions: DRUG: Anakinra 100 mg in 2 ml saline IA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparision of Different Dose of Neostigmine at Advanced Decurarization
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: neostigmine|DRUG: neostigmine|DRUG: neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy, Safety, and Immunogenicity of an EV71 Vaccine
Status: COMPLETED
Conditions: Enterovirus 71 Infection
Interventions: BIOLOGICAL: EV71vac|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Viral Infection in Asthma (VIA) Study
Status: RECRUITING
Conditions: Asthma
Interventions: DRUG: Dupilumab Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective, Open-label Study of Pharmacokinetics of Ertapenem in the Muscle Using Microdialysis in Mechanically Ventilated Intensive Care Unit Patients, Treated or Not by Norepinephrine
Status: TERMINATED
Conditions: To Assess the Tissular and Plasma Kinetics of Ertapenem
Interventions: DRUG: Ertapenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug-Related Problems and Healthcare Utilization Post-Hospital Discharge
Status: COMPLETED
Conditions: Drug Related Problems Post Hospital Discharge|Healthcare Utilization|Discharge Medication Counseling
Interventions: OTHER: RPh Counseling + Outpatient Med Dispensing at Discharge|OTHER: Discharge Med Dispensing Plus Counseling - Current Practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Vitamin D, Oxidative Stress and Inflammation in Hemodialysis
Status: COMPLETED
Conditions: Oxidative Stress|Inflammation|Vitamin D Deficiency
Interventions: DRUG: Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Single-Arm, Open-Label, Study to Evaluate the Safety and Efficacy of Single-Agent Lenalidomide (Revlimid, CC-5013) in Subjects With Androgen Independent Prostate Cancer.
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: CC5013
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Conjunctival Autografting With MMC Application Versus Ologen Implantation of Recurrent Pterygium
Status: COMPLETED
Conditions: Recurrent Pterygium of Eye
Interventions: PROCEDURE: conjunctival autografting augmented with topical application of Mitomycin C|PROCEDURE: conjunctival autografting augmented with Ologen implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Vitamin D Supplementation on Lung Function in an Acute Pulmonary Exacerbation of Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Toripalimab With or Without Celecoxib as Neoadjuvant Therapy in Resectable dMMR/MSI-H Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer|Mismatch Repair-deficient (dMMR)|Microsatellite Instability-high (MSI-H)|Neoadjuvant Therapy
Interventions: DRUG: Cohort 1: Neoadjuvant treatment with toripalimab plus celecoxib for 3 months|DRUG: Cohort 1: Neoadjuvant treatment with toripalimab monotherapy for 3 months|DRUG: Cohort 2: Neoadjuvant treatment with toripalimab plus celecoxib for 6 months|DRUG: Cohort 2: Neoadjuvant treatment with toripalimab monotherapy for 6 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-Human Single Ascending and Multiple Dose of GLPG0259
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG0259|DRUG: placebo|DRUG: GLPG0259|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Mucositis and Infection Reduction With Liquid Probiotics in Children With Cancer
Status: UNKNOWN
Conditions: Pediatric Cancer
Interventions: DIETARY_SUPPLEMENT: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Rapid Triage Test to Improve Risk-stratification of Febrile Children (EChiLiBRiST, Clinical Trial 1, Outpatients)
Status: NOT_YET_RECRUITING
Conditions: Infectious Disease|Febrile Illness|Child, Only
Interventions: OTHER: IMCI-enhanced by sTREM-1 levels (SoC + sTREM-1 POC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety/Efficacy of Valsartan/Hydrochlorothiazide Combination Compared to Hydrochlorothiazide in Obese Hypertensive Adults
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: HCTZ + Amlodipine|DRUG: Valsartan/HCTZ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Adverse Events, Optimal Dose, and Change in Disease Activity, With Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus IV Infused Pembrolizumab Plus Chemotherapy in Adult Participants With Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Livmoniplimab|DRUG: Budigalimab|DRUG: Pembrolizumab|DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Diabetes by Reconstruction Methods in Gastric Cancer Patients With Diabetes Mellitus
Status: UNKNOWN
Conditions: Gastric Cancer|Diabetes
Interventions: PROCEDURE: Roux-en Y gastrojejunostomy|PROCEDURE: Gastroduodenostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Isotretinoin on The Gonads and Hirsutism
Status: COMPLETED
Conditions: Adverse Effects of Medical Drugs
Interventions: DRUG: oral isotretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Stellate Ganglion Block in Patients With Parkinson's Disease
Status: WITHDRAWN
Conditions: Parkinson Disease
Interventions: PROCEDURE: Stellate ganglion block|BEHAVIORAL: Rehabilitation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determinants of Vascular Calcification in Chronic Renal Failure : Impact of Pyrophosphate Levels After Renal Transplantation
Status: COMPLETED
Conditions: Chronic Kidney Diseases
Interventions: PROCEDURE: Blood collection for Ppi assay|RADIATION: CT Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure
Status: RECRUITING
Conditions: Hemorrhage|Urgent Surgery|Invasive Procedure
Interventions: DRUG: Bentracimab (PB2452) Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Including a Chronic Pain Neuroscience Education Program for Individuals With Knee OA
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: OTHER: Therapeutic exercises|OTHER: Therapeutic exercises + pain neuroscience education program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Embodied Virtual Reality for Chronic Pain
Status: UNKNOWN
Conditions: Complex Regional Pain Syndromes|Complex Regional Pain Syndrome Type I of the Upper Limb|Complex Regional Pain Syndrome I (CRPS I)|Complex Regional Pain Syndrome I of Upper Limb|Complex Regional Pain Syndrome Type II|Complex Regional Pain Syndrome II of Upper Limb|Peripheral Nerve Injury Upper Limb|Osteoarthritis Hand|Osteoarthritis Finger
Interventions: DEVICE: Embodied virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CHIP-AML22/Quizartinib: Quizartinib + Chemotherapy in Newly Diagnosed Pediatric FLT3-ITD+ and NPM1wt AML Patients
Status: RECRUITING
Conditions: Acute Myeloid Leukemia in Children
Interventions: DRUG: Quizartinib|DRUG: Etoposide|DRUG: Dexrazoxane|DRUG: Mitoxantrone|DRUG: Cytarabine|DRUG: Methotrexate|DRUG: Daunorubicin|DRUG: Fludarabine|OTHER: allo-SCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Immunogenicity, and Efficacy of INO-4800 for COVID-19 in Adults at High Risk of SARS-CoV-2 Exposure
Status: TERMINATED
Conditions: Coronavirus Infection|Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)|COVID-19 Disease
Interventions: DRUG: INO-4800|DEVICE: CELLECTRA® 2000|DRUG: Placebo|DEVICE: CELLECTRA® 2000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Strengthening Effect on Hamstring's Passive Mechanical Properties
Status: COMPLETED
Conditions: Sports Physical Therapy
Interventions: OTHER: Concentric Exercise|OTHER: Nordic Eccentric exercise|OTHER: Neuromuscular Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Functional Electrical Stimulation in Cardiac Patients
Status: COMPLETED
Conditions: Coronary Disease|Heart Failure
Interventions: DEVICE: Functional Electrical Stimulation|DEVICE: Functional Electrical Stimulation placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effect and Safety of Combined Hydroxyurea With Recombinant Human Erythropoietin.
Status: UNKNOWN
Conditions: Thalassemia Intermedia
Interventions: DRUG: Hydroxyurea ,Epiao|DRUG: hydroxyurea, blood transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pelvic Floor 3D USG Three Years After Mid-urethral Slings ( TVT-R, TVT-O, TVT-S)
Status: COMPLETED
Conditions: Urinary Incontinence|Postoperative Period
Interventions: OTHER: 3D pelvic floor ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Effect, Safety and Tolerability of GSK1070806 in Atopic Dermatitis
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: GSK1070806|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Surveillance Monitoring as an Alternative to Telemetry
Status: TERMINATED
Conditions: Telemetry|Patient Monitoring
Interventions: DEVICE: Vital Sync IM & VPMP (Surveillance Monitoring)|DEVICE: Telemetry Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Determination of the Effects of Autogenic Relaxation Exercise and Cold Pillow Application on Vasomotor Symptom Control and Quality of Life in Postmenopausal Women
Status: COMPLETED
Conditions: Vasomotor Symptoms|Quality of Life
Interventions: DEVICE: cold pad pillow|BEHAVIORAL: autogenic training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effectiveness of Lifestyle Intervention on Body Composition, Physical Performances and Quality of Life Among Elderly People in Long-term Care Facilities
Status: COMPLETED
Conditions: Sarcopenia|Obesity
Interventions: BEHAVIORAL: Resistant Training|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Sitravatinib Plus Tislelizumab or Placebo Plus Tislelizumab Versus Placebo as Adjuvant Treatment in Participants With Hepatocellular Carcinoma
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Sitravatinib|DRUG: Tislelizumab|DRUG: sitravatinib-matching placebo|DRUG: tislelizumab-matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Open Label, Randomized-controlled Trial to Assess Efficacy Safety of HYALODISC With Physical Exercise Program
Status: RECRUITING
Conditions: Degenerative Disc Disease(DDD)
Interventions: DEVICE: Intradiscal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Blinatumomab Prevents Recurrence of R/R ALL After Allo-HSCT
Status: NOT_YET_RECRUITING
Conditions: Leukemia, Lymphoid
Interventions: DRUG: blinatumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: activeDCM - Interventional Clinical Trial of Individualized Activity and Exercise Programs to Improve Outcome in Dilated Cardiomyopathy Guided by Longitudinal Biosensing With Apple Watch
Status: RECRUITING
Conditions: Cardiomyopathy, Dilated|Heart Failure
Interventions: BEHAVIORAL: Individualized excercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of AstroStem in Treatment of Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: AstroStem|OTHER: Placebo-Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Algorithm of Muscle Function Tests to Detect Residual Neuromuscular Blockade.
Status: COMPLETED
Conditions: Postoperative Residual Curarization
Interventions: DEVICE: Acceleromyography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Femoral Neuropathy After Anterior Cruciate Ligament Reconstruction: Femoral Nerve Block vs Patient-controlled Analgesia (PCA)
Status: COMPLETED
Conditions: Femoral Neuropathy
Interventions: PROCEDURE: Femoral nerve block|PROCEDURE: PCA morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of the Safety and Pharmacokinetics of SAR245408 Tablets in Patients With Solid Tumors or Lymphoma
Status: COMPLETED
Conditions: Neoplasm Malignant
Interventions: DRUG: SAR245408
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-operative Chemotherapy Plus Bevacizumab With Early Salvage Therapy Based on PET Assessment of Response in Patients With Locally Advanced But Resectable Gastric and GEJ Adenocarcinoma
Status: COMPLETED
Conditions: Esophageal Cancer|Gastric Cancer
Interventions: DRUG: epirubicin, cisplatin, capecitabine, bevacizumab, docetaxel and irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Continuous Bevacizumab (Avastin) Treatment or Placebo in Addition to Lomustine Followed by Standard of Care After Disease Progression in Participants With Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: Bevacizumab|DRUG: Lomustine|DRUG: Placebo|RADIATION: Radiotherapy|DRUG: Temozolomide|DRUG: SOC Agent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of an Intervention to Reduce Gaps in Hypertension Care in Low-income Medellin, Colombia
Status: WITHDRAWN
Conditions: Hypertension
Interventions: OTHER: 1. Health Services Redesign|OTHER: 2. Clinical Staff Training|OTHER: 3. Patient and Community Engagement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Methylnaltrexone (MNTX) for the Relief of Constipation
Status: COMPLETED
Conditions: Advance Illness Patients With OIC
Interventions: DRUG: SC Methylnaltrexone|DRUG: SC Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficiency of Repetitive Transcranial Magnetic Stimulation (rTMS) Sessions After a Successful 3 Week-treatment in Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: rTMS|DEVICE: sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Revian Red All LED Cap as a Novel Treatment for Central Centrifugal Cicatricial Alopecia
Status: RECRUITING
Conditions: Central Centrifugal Cicatricial Alopecia
Interventions: DEVICE: Revian Red All LED cap
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Budesonide in Patients With Immune Mediated Enteropathies
Status: TERMINATED
Conditions: Enteropathy|Celiac Disease|CVID Enteropathy|Collagenous Sprue|Autoimmune Enteropathy
Interventions: DRUG: Withdrawal of Oral Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BMS-986166 or Branebrutinib for the Treatment of Participants With Atopic Dermatitis
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: BMS-986166|DRUG: Branebrutinib|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Positive Psychotheraphy and Antisocial Personality Disorder: Crime, Aggression, Anger
Status: COMPLETED
Conditions: Antisocial Personality Disorder
Interventions: BEHAVIORAL: Primary And Secondary Abilities Among The Individuals With Antisocial Personality Disorder Within The Scope Of Positive Psychotherapy: Their Relationship With Criminal Behaviors, Aggression And Anger
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination Chemotherapy With Suramin Plus Doxorubicin in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Adrenocortical Carcinoma|Breast Cancer|Colorectal Cancer|Prostate Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: doxorubicin hydrochloride|DRUG: suramin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Single Rising Oral Doses of BIRB 1017 BS as a Solution in PEG 400 / 26% Ethanol Administered to Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIBR 1017 BS powder|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: MLN0264 in Previously Treated Asian Participants With Advanced Gastrointestinal Carcinoma or Metastatic or Recurrent Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Guanylyl Cyclase C
Status: TERMINATED
Conditions: Advanced Gastrointestinal Carcinoma|Gastroesophageal Junction Adenocarcinoma|Recurrent Gastric Adenocarcinoma|Recurrent Gastroesophageal Junction Adenocarcinoma|Metastatic Gastric Adenocarcinoma|Metastatic Gastroesophageal Junction Adenocarcinoma|Recurrent Gastrointestinal Carcinoma
Interventions: DRUG: MLN0264
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Tafoxiparin on Cervical Ripening and Induction of Labor in Term Pregnant Women With an Unripe Cervix
Status: COMPLETED
Conditions: Labor Onset and Length Abnormalities
Interventions: DRUG: DF01|DRUG: PL1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EVALUATION OF THE RELATIONSHIP BETWEEN EFFERVESCENT PARACETAMOL AND BLOOD PRESSURE. CLINICAL TRIAL.
Status: UNKNOWN
Conditions: Hypertension|Chronic Disease of Musculoskeletal System
Interventions: DRUG: Non- effervescent Paracetamol kern|DRUG: Effervescent paracetamol termalgin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fed Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ibuprofen and Diphenhydramine Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Thymoglobulin and Tacrolimus in Liver Transplant
Status: UNKNOWN
Conditions: Liver Transplantation|Liver Disease|Immunosuppression
Interventions: DRUG: anti-thymocyte globulin (rabbit)|DRUG: tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of First Rank Symptoms (FRS) on Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia Patients With First Rank Symptoms
Interventions: DEVICE: rTMS treatment|DEVICE: placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate PF-04449913 With Chemotherapy In Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: PF-04449913|DRUG: Low dose ARA-C (LDAC)|DRUG: PF-04449913|DRUG: Decitabine|DRUG: PF-04449913|DRUG: Daunorubicin|DRUG: Cytarabine|DRUG: PF-04449913|DRUG: Daunorubicin|DRUG: Cytarabine|DRUG: PF-04449913|DRUG: Low dose ARA-C (LDAC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing Copanlisib as Potentially Targeting Treatment in Cancers With PTEN Expression (MATCH - Subprotocol Z1H)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lymphoma|Advanced Malignant Solid Neoplasm|Refractory Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Multiple Myeloma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Copanlisib|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cost-effectiveness of Remote Ischemic Conditioning as an Adjunct to Primary Percutaneous Coronary Intervention
Status: UNKNOWN
Conditions: ST-elevation Myocardial Infarction
Interventions: PROCEDURE: Remote ischemic conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coconut Oil in Treatment of Periodontitis
Status: COMPLETED
Conditions: Periodontal Diseases
Interventions: BIOLOGICAL: topical application of coconut oil|OTHER: scaling and debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Physical Therapy on Raynaud's Phenomenon Secondary to Systemic Sclerosis
Status: COMPLETED
Conditions: Raynaud's Phenomenon|Systemic Sclerosis
Interventions: OTHER: Biofeedback|OTHER: Deep oscillation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study to Investigate 14C-bemcentinib Following Single Oral Administration in Healthy Male Subjects
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer|Metastatic Melanoma|Acute Myeloid Leukemia|Myelodysplastic Syndromes|Metastatic Pancreatic Cancer|Glioblastoma|Malignant Mesothelioma|COVID-19
Interventions: DRUG: Bemcentinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Dutogliptin/PHX1149T to Treat Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: PHX1149T|DRUG: PHX1149T|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Median Effective Dose of Remifentanil for the Prevention of Pain Caused by the Injection of Rocuronium
Status: UNKNOWN
Conditions: Rocuronium|Injection Pain
Interventions: DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Use of Combined Prone Positioning and High-Flow Nasal Cannula, and Non-invasive Positive Pressure Ventilation to Prevent Intubation in COVID-19 Infection
Status: COMPLETED
Conditions: Prone Positioning|Covid19|Hypoxemic Respiratory Failure|ARDS|Non Invasive Ventilation|High Flow Nasal Cannulla
Interventions: OTHER: Body position change
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Co-Administration of LDX (SPD489) and Venlafaxine XR (EFFEXOR XR) in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LDX + Venlafaxine XR|DRUG: Venlafaxine XR + LDX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction Between SHR4640 Tablets and Furosemide Tablets in Healthy Volunteers (Single Center, Single Arm, Open, Self-control)
Status: COMPLETED
Conditions: Healthy Male Subjects
Interventions: DRUG: SHR4640 tablets and furosemide tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Tolerability of Ginkgo Biloba Extract in Patients With Raynaud´s Phenomenon
Status: COMPLETED
Conditions: Raynaud Disease
Interventions: DRUG: Ginkgo biloba extract EGb 761
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: REduced Dose Versus Full-dose of Direct Oral Anticoagulant After uNprOvoked Venous thromboEmbolism.
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DRUG: Reduced dose of DOAC|DRUG: Full dose of DOAC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of CP-751,871 in Combination With Carboplatin and Paclitaxel in Advanced Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: CP-751,871 + carboplatin + paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Dehydrated Human Amnion-Chorion and Type 1 Bovine Collagen Membranes for Guided Bone Regeneration
Status: COMPLETED
Conditions: Ridge Deficiency
Interventions: PROCEDURE: Guided Bone Regeneration (GBR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TenTaTorch: Venepuncture Made Easy
Status: UNKNOWN
Conditions: Vein Collapse|Vein Thrombosis|Vein; Tortuous|Vein Disease
Interventions: OTHER: Conventional|DEVICE: Veinlite|DEVICE: TenTaTorch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Extended Mesenteric Resection in Ileocecal Crohn's Disease.
Status: NOT_YET_RECRUITING
Conditions: Crohn's Disease of Terminal Ileum
Interventions: PROCEDURE: Standard laparoscopic ileocecal resection|PROCEDURE: Extended laparoscopic ileocecal resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety of Brexanolone in the Treatment of Adolescent Female Participants With Postpartum Depression (PPD)
Status: COMPLETED
Conditions: Post Partum Depression
Interventions: DRUG: Brexanolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Effectiveness and Safety Study Comparing Acetaminophen (3900 mg/Day) to Ibuprofen (1200 mg/Day) in the Treatment of Post-Race Muscle Soreness.
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: acetaminophen extended release caplets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Formulation and Evaluation of the Efficacy of Macro- and Micronutrient Sachets on Pregnant Mothers and Children Aged 6-60 Months
Status: UNKNOWN
Conditions: Pregnancy|Childhood
Interventions: DIETARY_SUPPLEMENT: micro-and macro-nutrients fortified sachets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION