pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Clinical Trial of Adjunctive and Monotherapy PRAX-114 in Participants With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: 10 mg PRAX-114|DRUG: 20 mg PRAX-114|DRUG: 40 mg PRAX-114|DRUG: 60 mg PRAX-114|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Left Ventricular Dysfunction in Critically Ill Patients
Status: COMPLETED
Conditions: Left Ventricular Dysfunction|Critically Ill|Acute Coronary Syndrome|Cardiomyopathies|Takotsubo Cardiomyopathy
Interventions: DIAGNOSTIC_TEST: Echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Manual Compression and Stretching for The Myofascial Trigger Points in Upper Trapezius and Levator Scapulae
Status: RECRUITING
Conditions: Myofascial Trigger Point Pain
Interventions: DIAGNOSTIC_TEST: Manual Compression and Stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia|Non-Hodgkin's Lymphoma
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anastrozole Plus Lonafarnib (SCH 66336) or Plus Placebo for the Treatment of Advanced Breast Cancer (P03480)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Lonafarnib|DRUG: Placebo|DRUG: anastrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Tailored Adherence Incentives for Childhood Asthma Medications (TAICAM) Trial
Status: COMPLETED
Conditions: Medication Adherence|Asthma in Children
Interventions: OTHER: Nominal Financial Incentives|OTHER: Daily Adherence Reminders/Adherence Performance Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Does Addition of a Functional Knee Brace Improve Rehabilitation Outcome in Subjects With Osteoarthritis of the Knee?
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: functional knee brace
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polyglutamate Paclitaxel Plus Carboplatin Compared With Paclitaxel Plus Carboplatin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: paclitaxel|DRUG: paclitaxel poliglumex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Levonorgestrel-releasing Intrauterine Device (IUD) Versus a Copper Containing IUD on Risk of Blood Clots
Status: UNKNOWN
Conditions: Blood Coagulation Disorders
Interventions: DEVICE: Levonorgestrel-containing IUD (Mirena®)|DEVICE: Copper-containing IUD (Paraguard®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Indomethacin Decreases Post-ERCP Pancreatitis
Status: COMPLETED
Conditions: Post ERCP Acute Pancreatitis
Interventions: DRUG: Indomethacin|DRUG: 2.6-g suppository of glycerin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-escalation of Siltuximab in Combination With Idarubicin and Cytarabine Chemotherapy in Patients With Acute Myeloblastic Leukaemia (AML) With Poor Prognosis: SILTUXILAM
Status: RECRUITING
Conditions: Acute Myeloid Leukemia (AML)
Interventions: DRUG: Siltuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults
Status: RECRUITING
Conditions: Diffuse Midline Glioma, H3 K27M-Mutant|Recurrent High Grade Glioma
Interventions: DRUG: Treatment with CD200AR-L
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Head Positions to Open the Airway IV
Status: COMPLETED
Conditions: Cardiac or Respiratory Arrest, Anaesthesia
Interventions: PROCEDURE: head extension|PROCEDURE: neutral position|PROCEDURE: anaesthesiologist´s position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Fluorescence Detection of Adult Primary Central Nervous System Tumors With Tozuleristide and the Canvas System
Status: RECRUITING
Conditions: Central Nervous System Tumor
Interventions: DRUG: tozuleristide|DEVICE: Canvas imaging system|PROCEDURE: Surgical resection of tumor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous NTG to Preserve Gastric Microcirculation During Gastric Tube Reconstruction
Status: COMPLETED
Conditions: Esophageal Neoplasms|Microcirculation
Interventions: DRUG: Nitroglycerin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Eye Health Benefits of Blueberry Chewable Tablets
Status: COMPLETED
Conditions: Eye
Interventions: DIETARY_SUPPLEMENT: Placebo tablets|DIETARY_SUPPLEMENT: Blueberry Chewable Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of High-Dose Capsaicin Patches to Treat Postherpetic Neuralgia Pain
Status: COMPLETED
Conditions: Neuralgia|Pain|Peripheral Nervous System Diseases|Herpes Zoster
Interventions: DRUG: Capsaicin Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Immunogenicity, and Antitumor Activity of GEN-009 Adjuvanted Vaccine
Status: COMPLETED
Conditions: Cutaneous Melanoma|Non-small Cell Lung Cancer|Squamous Cell Carcinoma of the Head and Neck|Urothelial Carcinoma|Renal Cell Carcinoma
Interventions: BIOLOGICAL: GEN-009 Adjuvanted Vaccine|DRUG: Nivolumab|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Understanding Pre-Exposure pRophylaxis of NOVel Antibodies (SUPERNOVA) Sub-study: Study Understanding Pre-Exposure pRophylaxis of NOVel Antibodies (SUPERNOVA) Sub-study
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19, SARS-CoV-2
Interventions: BIOLOGICAL: AZD5156 (Parent study Sentinel Safety Cohort)|BIOLOGICAL: Placebo (Parent study Sentinel Safety Cohort)|BIOLOGICAL: EVUSHELD™ (Parent study Main Cohort)|BIOLOGICAL: AZD3152 (Parent study Main Cohort)|BIOLOGICAL: Placebo (Parent study Main Cohort)|BIOLOGICAL: AZD3152 (Sub-study)|BIOLOGICAL: AZD7442 - EVUSHELD™ (Sub-study)|BIOLOGICAL: AZD7442 (EVUSHELD™) (Sub-study) Immunocompromised participants offered AZD3152
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Topical Aminolevulinic Acid in Patients With Nonmelanoma Skin Cancer
Status: TERMINATED
Conditions: Non-melanomatous Skin Cancer
Interventions: DRUG: Aminolevulinic Acid|PROCEDURE: biopsy|PROCEDURE: diagnostic imaging technique|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Paclitaxel Poliglumex and Estradiol in Treating Patients With Stage IV Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: transdermal estradiol|DRUG: paclitaxel poliglumex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Idelalisib-Associated Diarrhea in Patients With Relapsed Chronic Lymphocytic Leukemia, Indolent Non-hodgkin Lymphoma, or Small Lymphocytic Lymphoma
Status: TERMINATED
Conditions: Absence of Signs or Symptoms|B-Cell Non-Hodgkin Lymphoma|Digestive System Signs and Symptoms|Indolent Adult Non-Hodgkin Lymphoma|Recurrent B-Cell Non-Hodgkin Lymphoma|Recurrent Chronic Lymphocytic Leukemia|Recurrent Indolent Adult Non-Hodgkin Lymphoma|Recurrent Small Lymphocytic Lymphoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Colonoscopy|PROCEDURE: Colposcopic Biopsy|DRUG: Idelalisib|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|PROCEDURE: Physical Examination|PROCEDURE: Sigmoidoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Drug Interaction Between Irbesartan and Hydrochlorothiazide
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Irbeasartan/hydrochlorothiazide|DRUG: Irbesartan|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Administration of Antibiotic Prophylaxis for Transperineal Prostate Biopsy in Cipto Mangunkusumo Hospital
Status: UNKNOWN
Conditions: Prostate Cancer|Prostate Biopsy|Perioperative Complication|Bacteriuria|Urinary Tract Infections|Sepsis
Interventions: DRUG: Cotrimoxazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Fetoscopes Used in Fetoscopic Selective Laser Photocoagulation
Status: NOT_YET_RECRUITING
Conditions: Twin Monochorionic Diamniotic Placenta
Interventions: DEVICE: Fetoscopy Sets for Anterior and Posterior Placentas
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of DA-5219 in Patients With Acute or Chronic Gastritis
Status: RECRUITING
Conditions: Gastritis Acute|Gastritis Chronic
Interventions: DRUG: DA-5219|DRUG: Stillen® Tab|DRUG: DA-5219 Placebo|DRUG: Stillen® Tab Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Intravenous Mircera for the Treatment of Anemia in Dialysis Patients
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Epoetin alfa or beta|DRUG: RO0503821 (1x/2 Weeks)|DRUG: RO0503821 (1x/4 Weeks)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Administration of Virus Specific CTLs for the Prophylaxis and Treatment of EBV/CMV Infections After HSCT in China
Status: UNKNOWN
Conditions: Viral Infection
Interventions: BIOLOGICAL: CMV/EBV specific CTLs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Japanese Trial of TH-302 in Subjects With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma
Status: TERMINATED
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: TH-302|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab or Nivolumab Plus Cisplatin, in Combination With Radiotherapy in Patients With Cisplatin-ineligible or Eligible Locally Advanced Squamous Cell Head and Neck Cancer
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: BIOLOGICAL: Nivolumab|DRUG: Cetuximab|DRUG: Cisplatin|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
Status: RECRUITING
Conditions: Ischemic Stroke|Intracerebral Hemorrhage|Subarachnoid Hemorrhage|Dementia, Vascular|Mild Cognitive Impairment|Vascular Cognitive Impairment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Words on the Brain: Can Reading Rehabilitation for Age-Related Vision Impairment Improve Cognitive Functioning?
Status: TERMINATED
Conditions: Age-related Macular Degeneration|Dementia|Low Vision|Low Vision Aids|Hearing Loss|Reading Problem|Cognitive Impairment
Interventions: BEHAVIORAL: Low Vision Reading Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biweekly SOLAR, as First-line C/T in Pts With Gastric, Pancreatic and Biliary Cancers
Status: COMPLETED
Conditions: Gastric Cancer in Situ|Pancreatic Cancers|Biliary Cancers
Interventions: DRUG: Oxaliplatin|DRUG: Albumin-Bound Paclitaxel /nab-Paclitaxel|DRUG: S-1|DRUG: LV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myocardial Ischemia Detection With a Combined Cardiovascular Magnetic Resonance and Biomarker Protocol
Status: NOT_YET_RECRUITING
Conditions: Myocardial Ischemia Demand
Interventions: DIAGNOSTIC_TEST: Exercise in combination with biomarkers and pharmacological stress CMR test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Respiratory Strength Training in Persons With Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DEVICE: PowerLung trainer|DEVICE: Micro Mouth Pressure Meter|PROCEDURE: Pulmonary Function Testing|PROCEDURE: Videofluoroscopic swallowing study|OTHER: Swallowing Quality of Life Questionnaire|DEVICE: Iowa Oral Pressure Instrument|DRUG: Capsaicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prone Positioning CT Scan and Ultrasound Assessing Axillary Lymph Nodes in Patients With Breast Cancer Official Title: Evaluation of Axillary Lymph Nodes Using Prone Positioning Computed Tomography Scan and Ultrasound in Patients With Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: PROCEDURE: ALND Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: MRI Study of Cerebral Blood Flow in Development Disorders in Children
Status: RECRUITING
Conditions: Autism
Interventions: PROCEDURE: ASL-MRI|PROCEDURE: Diffusion tensor imaging (diffusion MRI)|PROCEDURE: Resting state MRI|PROCEDURE: Eye-tracking|PROCEDURE: Cognitive profile
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Hepatic Arterial Infusion of Floxuridine, Gemcitabine Hydrochloride, and Radiolabeled Monoclonal Antibody Therapy in Treating Liver Metastases in Patients With Metastatic Colorectal Cancer Previously Treated With Surgery
Status: COMPLETED
Conditions: Liver Metastases|Recurrent Colon Cancer|Recurrent Rectal Cancer|Stage IV Colon Cancer|Stage IV Rectal Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: floxuridine|GENETIC: proteomic profiling|OTHER: matrix-assisted laser desorption/ionization time of flight mass spectrometry|OTHER: liquid chromatography|RADIATION: yttrium Y 90 anti-CEA monoclonal antibody cT84.66|OTHER: laboratory biomarker analysis|OTHER: mass spectrometry|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Volatile Anesthetics to Reduce Mortality in Cardiac Surgery
Status: COMPLETED
Conditions: Aortocoronary Bypass|Cardiac Surgery|Coronary Artery Bypass Grafting
Interventions: DRUG: desflurane, isoflurane, sevoflurane|DRUG: total intravenous anesthetics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing Acceptability, Cost, and Efficacy of STELLA-Support Via Technology
Status: COMPLETED
Conditions: Dementia|Alzheimer Disease|Caregiver Burnout|Family Members
Interventions: BEHAVIORAL: STELLA (Support via TEchnology: Living and Learning with Advancing Alzheimer's disease and related dementias)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Placebo Controlled Trial of SOM230 for the Reduction of Post-Pancreatectomy Fistula, Leak, and Abscess
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Pasireotide (SOM230)|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparaison of 2 SpO2 Level Measured by Pulse Oxymetry in Complications of Acute Coronary Syndrome.
Status: COMPLETED
Conditions: Infarction, Myocardial
Interventions: DEVICE: Automated oxygen administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Role of Intravenous Versus Home Oral Antibiotics in Perforated Appendicitis
Status: COMPLETED
Conditions: Perforated Appendicitis
Interventions: DRUG: home intravenous ertapenem|DRUG: home oral amoxicillin-clavulanate|DEVICE: peripheral inserted central Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Pursed Lip Breathing Technique Versus Stacked Breathing Technique Among Chronic Bronchitis Patients
Status: COMPLETED
Conditions: Chronic Bronchitis
Interventions: OTHER: pursed lip|OTHER: Stacked Breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Accelerated Partial Breast Irradiation for Early Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: RADIATION: Accelerated partial breast irradiation (APBI) to region of tumour bed using 3D conformal radiation therapy (3D CRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimisation of Cardiac Resynchronisation Therapy by Non-invasive Cardiac Output - The CHOICE2 Study
Status: COMPLETED
Conditions: Heart Failure|Cardiac Resynchronisation Pacemakers
Interventions: DEVICE: Optimisation of VV delay
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Primary Excision Combined With Preoperative Neoadjuvant and Adjuvant Therapy for Oligometastasis of Urothelial Carcinoma
Status: RECRUITING
Conditions: Bladder Urothelial Carcinoma
Interventions: PROCEDURE: primary focal resection plus lymph node dissection|DRUG: Tislelizumab|DRUG: Gemcitabine plus cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety and Immunogenicity of Different Formulations of GSK Biologicals' Meningococcal ACWY Conjugate Vaccine (GSK3536820A and Menveo) Administered to Healthy Adults 18 to 40 Years of Age
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: MenACWY liquid vaccine with approximately 30% MenA FS (GSK3536820A)|BIOLOGICAL: Licensed GSK MenACWY vaccine (Menveo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dietary Intervention for Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: OTHER: Experimental Diet|OTHER: Comparator Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Follow-up Study to Assess Long-term Immunogenicity and Safety of NicVAX/Placebo as an Aid to Smoking Cessation
Status: COMPLETED
Conditions: Smoking Cessation|Nicotine Dependence
Interventions: BIOLOGICAL: NicVAX vaccine|BIOLOGICAL: Placebo
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Adding Midzolam to Bupavicaine 0.5% in Regional Spinal Anaesthesia on Maternal Middle Cerebral Artery Velocimetry in Parturients With Severer Preeclampsia
Status: UNKNOWN
Conditions: Midazolam in Preeclamptic Patients
Interventions: DRUG: intrthecl midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Revlimid, Melphalan and Dexamethasone as First Line Treatment for Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Lenalidomide (Revlimid)|DRUG: Melphalan|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of EMDR Therapy in Patients With Severe Obesity
Status: UNKNOWN
Conditions: Obesity|Emotional Trauma
Interventions: BEHAVIORAL: Personality Factor Battery Test (PFB Test)|BEHAVIORAL: Eye Movement Desensitization and Reprocessing Therapy (EMDR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Response Associated With Parent-based Treatment for Childhood Anxiety Disorders
Status: COMPLETED
Conditions: Anxiety Disorder of Childhood|Separation Anxiety Disorder of Childhood|Social Anxiety Disorder of Childhood|Generalized Anxiety Disorder
Interventions: BEHAVIORAL: Supportive Parenting for Anxious Childhood Emotions|BEHAVIORAL: Parent Educational Support|BEHAVIORAL: Cognitive-Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a Signal-processing Algorithm Aiming at Improving Speech-in-noise Intelligibility in Normal-hearing and Hearing-impaired Persons
Status: RECRUITING
Conditions: Speech Intelligibility in Noise
Interventions: DEVICE: The device is an algorithm designed to enhance speech intelligibility of speech-in-noise signals
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Biomarkers to Predict the Efficacy of IL-4R Monoclonal Antibody for Chronic Rhino-sinusitis With Polyps
Status: UNKNOWN
Conditions: Chronic Rhino-sinusitis|IL-4R|Monoclonal Antibody|Biomarker
Interventions: OTHER: IL-4R|OTHER: Placebo
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CoreHip - Post Market Clinical Follow-Up Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Degenerative Osteoarthritis|Rheumatic Arthritis|Fractures, Hip|Necrosis, Femur Head
Interventions: DEVICE: CoreHip Total Hip Arthroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Integrated Behavioral Health Prevention in Pediatric Primary Care for Infants
Status: COMPLETED
Conditions: Prevention
Interventions: BEHAVIORAL: Integrated Behavioral Health - Prevention|BEHAVIORAL: Bright Futures: Guidelines for Health Supervision of Infants, Children, and Adolescents, 4th Edition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate if Inhaled Nitric Oxide Improves Liver Function After Transplantation
Status: COMPLETED
Conditions: Reperfusion Injury|Liver Injury
Interventions: DRUG: inhaled nitric oxide|DRUG: nitrogen gas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient-Provider Tools to Improve the Transition to Adult Care in Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: BEHAVIORAL: Self-management intervention for Adolescents with SCD|BEHAVIORAL: Patient Portal Intervention for Adolescents with SCD
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Interaction Study Between Budesonide and Metronidazole in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Budesonide 2 single doses, Metronidazole multiple-dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes
Status: RECRUITING
Conditions: Metastatic Malignant Solid Neoplasm|Unresectable Malignant Solid Neoplasm
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Diagnostic Imaging|BIOLOGICAL: Novobiocin Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Milk Powder Intervention on Body Composition and Physical Performance in Middle-aged and Older Adults
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: fortified formula milk powder|DIETARY_SUPPLEMENT: formula milk powder|DIETARY_SUPPLEMENT: regular milk powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Application of Early Bundle Management of Mechanical Ventilation to Prevent Ventilator Dependence in Children
Status: RECRUITING
Conditions: Prolonged Mechanical Ventilation
Interventions: BEHAVIORAL: early bedside rehabilitation|DIETARY_SUPPLEMENT: nutrition program|PROCEDURE: tracheotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Azathioprine and Prednisone in the Treatment of Idiopathic Pulmonary Fibrosis
Status: UNKNOWN
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Placebo|DRUG: AZAPRED
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of OT-101 in Treating Myopia
Status: ACTIVE_NOT_RECRUITING
Conditions: Myopia, Progressive
Interventions: DRUG: OT-101 Ophthalmic Solution|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Androgen Reduction in Congenital Adrenal Hyperplasia, Phase 1
Status: SUSPENDED
Conditions: Congenital Adrenal Hyperplasia
Interventions: DRUG: Abiraterone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rifaximin in Minimal Hepatic Encephalopathy
Status: COMPLETED
Conditions: Hepatic Encephalopathy
Interventions: DRUG: Rifaximin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics and Safety Between HCP2303 and Co-administration of Each Component in Healthy Volunteers Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HCP2303|DRUG: RLD2302|DRUG: RLD2102
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparaison of 3 Protocols of Ocytocin Administration in C Section
Status: COMPLETED
Conditions: Cesarean Section Complications|Oxytocin Adverse Reaction
Interventions: DRUG: Ocytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate Food Occlusion Efficacy of a Denture Adhesive in Denture Wearers
Status: COMPLETED
Conditions: Denture Retention
Interventions: COMBINATION_PRODUCT: Marketed Denture Adhesive (Super Poligrip Max Seal)|OTHER: No Adhesive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Problem Solving and Cardiovascular Disease Risk Management in Diabetic Blacks
Status: COMPLETED
Conditions: Cardiovascular Diseases|Heart Diseases|Diabetes Mellitus, Type 2|Coronary Disease
Interventions: BEHAVIORAL: Problem Solving Skills|BEHAVIORAL: Problem Solving Skills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of an Amino Acid Supplement on Glucose Levels in Obese Subjects
Status: COMPLETED
Conditions: Pre-diabetes|Obese|Glucose Intolerance
Interventions: DIETARY_SUPPLEMENT: BCAA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chronic Effects of Wide-pulse Neuromuscular Electrostimulation on Neuromuscular and Functional Properties in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DEVICE: Wide-pulse neuromuscular electrostimulation (WP NMES)|DEVICE: Conventional neuromuscular electrostimulation (CONV NMES)|DEVICE: Control (CONT) modality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Perioperative CBT on Chronic Persistent Postsurgical Pain Among Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer|Chronic Pain|Chronic Postsurgical Pain|Quality of Life
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy (CBT)|BEHAVIORAL: Education and Mindfulness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study Which Evaluate Intravesical Instillation With Mitomycin C Mixed With TC-3 Drug Retaining Hydrogel Device In Patients With Muscle Invasive Bladder Cancer
Status: COMPLETED
Conditions: Carcinoma of Urinary Bladder, Invasive
Interventions: DEVICE: TC-3 gel|DEVICE: TC-3 gel mixed with Mitomycin C (MMC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: XELOX for 4 Months Versus 6 Months in Gastric Cancer (LOMAC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Oxaliplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nerve Grafting Technique to Preserve Erectile Function in Patients Undergoing Robotic Assisted Radical Prostatectomy
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer|Erectile Dysfunction
Interventions: PROCEDURE: Intraoperative Somatic-Autonomic Nerve Grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anastrozole and Fulvestrant Compared to Anastrozole as Adjuvant Treatment of Postmenopausal Patients With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Fulvestrant|DRUG: Anastrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of NN1250 With Sitagliptin in Subjects With Type 2 Diabetes Never Treated With Insulin
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec|DRUG: sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Cognitive Behavior Therapy for People With Post-traumatic Stress and Cardiovascular Illness
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic
Interventions: BEHAVIORAL: Cognitive behavioral therapy (CBT)|BEHAVIORAL: Educational session and treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Linifanib in Treating Patients With Advanced, Refractory Colorectal Cancer
Status: TERMINATED
Conditions: Recurrent Colon Cancer|Recurrent Rectal Cancer|Stage IVA Colon Cancer|Stage IVA Rectal Cancer|Stage IVB Colon Cancer|Stage IVB Rectal Cancer
Interventions: DRUG: linifanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Changes in Bowel Movement Frequency Following the Consumption of PHGG Compared to Placebo
Status: COMPLETED
Conditions: Constipation - Functional
Interventions: DIETARY_SUPPLEMENT: PHGG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Gastric Emptying in Elderly With Hip Fracture
Status: COMPLETED
Conditions: Gastroparesis|Hip Fracture|Mild Insufficient Nutrition
Interventions: PROCEDURE: Gastric emptying of carbohydrate-rich beverage|PROCEDURE: Gastric emptying of carbohydrate-rich beverage|PROCEDURE: Gastric emptying of carbohydrate-rich beverage
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tobacco Treatment Using EMDR (ToTEM)
Status: TERMINATED
Conditions: Tobacco Use Disorder
Interventions: BEHAVIORAL: TAU + Addiction focussed - eye movement desensitization and reprocessing (AF-EMDR)|BEHAVIORAL: TAU only: Community Reinforcement Approach (CRA) + SCP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Randomized Study of Intravenous Versus Oral Clomipramine in Patients With Obsessive Compulsive Disorder
Status: UNKNOWN
Conditions: Obsessive-Compulsive Disorder
Interventions: DRUG: Clomipramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy/Safety Study of Glimepiride to Type 2 Diabetes Patients Based on Metformin And Basal Insulin Treatment
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: glimepiride|DRUG: glargine and metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Hallux Terbinafine Subungual Gel (HSG) in the Treatment of Onychomycosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Onychomycosis of Toenail
Interventions: DRUG: Hallux Terbinafine Subungual Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of VG161 in the Treatment of Advanced Bone and Soft Tissue Sarcoma
Status: RECRUITING
Conditions: Sarcoma
Interventions: DRUG: Recombinant Human IL12/15-PDL1B Oncolytic HSV-1 Injection (Vero Cell)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Structured Progressive Task-Oriented Circuit Class Training With Motor Imagery on Gait in Stroke
Status: COMPLETED
Conditions: Stroke|Gait, Hemiplegic
Interventions: PROCEDURE: Motor imagery|PROCEDURE: Health education|PROCEDURE: Task-Oriented Circuit Class Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brain Markers of Improvements in Cognitive Functioning
Status: COMPLETED
Conditions: TBI (Traumatic Brain Injury)|Brain Injuries|Stress|Attention Deficit|Executive Dysfunction
Interventions: BEHAVIORAL: State regulation skill training|OTHER: Treatment-as-usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acidophilus Pearls Fecal Recovery Study
Status: COMPLETED
Conditions: Survival of Probiotics During GI Transit|GI Symptoms
Interventions: DIETARY_SUPPLEMENT: Acidophilus pearls|DIETARY_SUPPLEMENT: Hard shell gelatin capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Intravenous MK-8226 in Participants With Moderate-to-Severe Atopic Dermatitis (MK-8226-003)
Status: TERMINATED
Conditions: Atopic Dermatitis
Interventions: DRUG: MK-8226|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of HS-10382 Combination in Patients With Chronic Myeloid Leukemia (CML)
Status: NOT_YET_RECRUITING
Conditions: Chronic Myelogenous Leukemia|CML Chronic Phase|CML Accelerated Phase
Interventions: DRUG: HS-10382+Flumatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Multiple Interventions to Improve HIV Treatment Outcomes Among People Who Inject Drugs in India
Status: RECRUITING
Conditions: HIV Infections
Interventions: BEHAVIORAL: Same-day ART initiation [experimental]|BEHAVIORAL: Standard ART initiation [usual care]|OTHER: Community-based HIV care [experimental]|OTHER: Government-based HIV care [usual care]|BEHAVIORAL: Enhanced adherence support [experimental]|BEHAVIORAL: Routine adherence support [usual care]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Avelumab in First-Line Maintenance Gastric Cancer (JAVELIN Gastric 100)
Status: COMPLETED
Conditions: Unresectable, Locally Advanced or Metastatic, Adenocarcinoma of the Stomach, or of the Gastro Esophageal Junction
Interventions: DRUG: Avelumab|DRUG: Oxaliplatin|DRUG: 5-Fluorouracil|DRUG: Leucovorin|DRUG: Capecitabine|OTHER: Best supportive care|DRUG: Oxaliplatin|DRUG: 5-Fluorouracil|DRUG: Leucovorin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigational Surgical Procedure (Vascularized Lymph Node Transfer) in Reducing the Risk of Lymphedema in Patients With Breast Cancer Undergoing Breast Reconstruction
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Carcinoma
Interventions: PROCEDURE: Mammoplasty|PROCEDURE: Vascularized Lymph Node Transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Montreal Safety and Efficacy of the Percutaneous Transvenous Mitral Annuloplasty Device
Status: COMPLETED
Conditions: Heart Failure|Mitral Regurgitation
Interventions: DEVICE: PTMA (Percutaneous Transvenous Mitral Annuloplasty) Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Hydroxyurea and Verapamil for Refractory Meningiomas
Status: COMPLETED
Conditions: Cancer|Brain Cancer|Meningioma
Interventions: DRUG: Hydroxyurea|DRUG: Verapamil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Fleming [FMTVDM] Directed CoVid-19 Treatment Protocol
Status: COMPLETED
Conditions: CoVid 19 Positive
Interventions: DRUG: Hydroxychloroquine, Azithromycin|DRUG: Hydroxychloroquine, Doxycycline|DRUG: Hydroxychloroquine, Clindamycin|DRUG: Hydroxychloroquine, Clindamycin, Primaquine - low dose.|DRUG: Hydroxychloroquine, Clindamycin, Primaquine - high dose.|DRUG: Remdesivir|DRUG: Tocilizumab|DRUG: Methylprednisolone|DRUG: Interferon-Alpha2B|DRUG: Losartan|DRUG: Convalescent Serum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Nicotine in Preventing COVID-19 Infection
Status: UNKNOWN
Conditions: Covid19|SARS-Associated Coronavirus as Cause of Disease Classified Elsewhere
Interventions: DRUG: Nicotine patch|DRUG: Placebo patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Free Gingival Graft and Modified Apical Repositioning Flap Techniques
Status: TERMINATED
Conditions: Periodontal Diseases
Interventions: OTHER: Patients selection|OTHER: Recall visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dual-Task Training for People With Mild Cognitive Impairment and Mild Dementia
Status: NOT_YET_RECRUITING
Conditions: Dementia|Mild Cognitive Impairment|Older Adult
Interventions: BEHAVIORAL: Dual-task training|BEHAVIORAL: Cognitive training|BEHAVIORAL: Motor training|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Mannequin Study to Assess Various CPR Training Methods Using a Student Population
Status: COMPLETED
Conditions: Cardiac Arrest|Heart Disease
Interventions: OTHER: AHA CPR Anytime Video Self-Instruction Kit|OTHER: AHA CPR Anytime DVD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: AI Driven Biofeedback Wearable
Status: COMPLETED
Conditions: Knee Injuries
Interventions: DEVICE: Biofeedback Knee Sleeve|DEVICE: Sham Biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Anti-SARS Cov-2 T Cell Infusions for COVID 19
Status: TERMINATED
Conditions: SARS-CoV 2|Viral Infection|COVID 19
Interventions: BIOLOGICAL: Dose Finding Phase (MTD)|BIOLOGICAL: Partially HLA-matched SARS-CoVSTs|OTHER: Routine care (no SARS-CoVSTs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Monosialotetrahexosylganglioside in the Prophylactic Treatment of Bortezomib-induced Peripheral Neuropathy
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Monosialotetrahexosylganglioside
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TMS for Symptom Reduction in Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia and Related Disorders
Interventions: DEVICE: Active rTMS stimulation|DEVICE: Sham rTMS stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Selective JAK 1 Inhibitor Filgotinib in Active Rheumatoid Arthritis Patients With Inadequate Response to Methotrexate
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|JAK Inhibitor|IL-6 Inhibitor|Musculoskeletal Ultrasound|Biomarker
Interventions: DRUG: filgotinib 200mg/day|DRUG: subcutaneous tocilizumab 162mg/biweekly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Alternating Current Stimulation (tACS) for Cognitive Impairments in Patients With Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DEVICE: Active tACS|DEVICE: Sham tACS|DEVICE: Active boosting|DEVICE: Sham boosting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Alanine in Fructose Intolerance: A Dose Ranging Study
Status: UNKNOWN
Conditions: Fructose Intolerance
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Alanine|DIETARY_SUPPLEMENT: Alanine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Global Study of Midostaurin in Combination With Chemotherapy to Evaluate Safety, Efficacy and Pharmacokinetics in Newly Diagnosed Pediatric Patients With FLT3 Mutated AML
Status: RECRUITING
Conditions: FLT3-mutated Acute Myeloid Leukemia
Interventions: DRUG: Midostaurin|DRUG: Fludarabine|DRUG: Cytarabine|DRUG: Daunorubicin or idarubicin|DRUG: Mitoxantrone|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Steroid-reducing Effects of Crisaborole
Status: COMPLETED
Conditions: Atopic Dermatitis|Eczema
Interventions: DRUG: Crisaborole|DRUG: Hydrocortisone Ointment|DRUG: Triamcinolone ointment|DRUG: Aquaphor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT