pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Sitagliptin Effects on Arterial Vasculature and Inflammation in Obesity
Status: COMPLETED
Conditions: Atherosclerosis|Inflammation
Interventions: DRUG: Sitagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Assess the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Oral Semaglutide in Healthy Male Japanese and Caucasian Subjects
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2|Healthy
Interventions: DRUG: semaglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Targeting Physical Health in Schizophrenia: Physical Activity Can Enhance Life
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Brief Psychotic Disorder|Schizophreniform Disorder|Unspecified Schizophrenia Spectrum and Other Psychotic Disorder
Interventions: BEHAVIORAL: Exercise Intervention- PACE-Life
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Anti-oxidant Effects of N-Acetylcysteine in Chronic Obstructive Pulmonary Disease (COPD)
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: N-acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assess the Efficacy, Safety and Tolerability of Gefitinib (Iressa® 250mg) as Maintenance Therapy in Locally Advanced or Metastatic (Stage IIIB/IV) Non Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: DRUG: Gefitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency Department
Status: COMPLETED
Conditions: Depression|Depression Severe|Depression Acute|Depression and Suicide|Suicidal Ideation
Interventions: DRUG: Ketamine|DRUG: Sodium Chloride 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Everolimus Combined With Octreotide LAR to Treat Advanced GI NET
Status: COMPLETED
Conditions: Gastrointestinal Neoplasms
Interventions: DRUG: Everolimus|DRUG: octreotide LAR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Mavorixafor in Participants With Congenital Neutropenia and Chronic Idiopathic Neutropenia Disorders
Status: ACTIVE_NOT_RECRUITING
Conditions: Neutropenia
Interventions: DRUG: Mavorixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee
Status: COMPLETED
Conditions: Chronic Pain|Osteoarthritis, Hip|Osteoarthritis, Knee
Interventions: DRUG: NSAID|BIOLOGICAL: Tanezumab 2.5 mg|BIOLOGICAL: Tanezumab 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Two Trivalent Subunit Influenza Vaccines in Healthy Adult Subjects
Status: COMPLETED
Conditions: Prophylaxis: Influenza
Interventions: BIOLOGICAL: TIVc_LOT A|BIOLOGICAL: TIVc_LOT B|BIOLOGICAL: TIVc_LOT C|BIOLOGICAL: TIVf
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study to Improve OS in 18 to 60 Year-old Patients, Comparing Daunorubicin Versus High Dose Idarubicin Induction Regimens, High Dose Versus Intermediate Dose Cytarabine Consolidation Regimens, and Standard Versus MMF Prophylaxis of GvHD in Allografted Patients in First CR
Status: RECRUITING
Conditions: Acute Myeloid Leukemia (AML)
Interventions: DRUG: Idarubicin|DRUG: Daunorubicin|DRUG: HD Cytarabine|DRUG: Cyclosporine|DRUG: Methotrexate|DRUG: Mycophenolic acid (MPA)|DRUG: vosaroxin|DRUG: ID cytarabine|DRUG: Dexamethasone|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of an Opioid Disposal Pouch Versus Usual Care on Post Discharge Disposal of Unused Medication
Status: COMPLETED
Conditions: Drug Prescriptions
Interventions: OTHER: Disposal pouch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: LFB-R603 Dose Finding in Patients With Advanced Stage B-Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: LFB-R603
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Scapular Stabilization Versus Thoracic Spine Extension Exercises in Mechanical Neck Pain
Status: COMPLETED
Conditions: Neck Pain
Interventions: OTHER: scapular stabilization|OTHER: Thoracic extension exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intraoperative Dexamethasone Implant in Taut Posterior Hyaloid Removal in Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema|Vision Disorders
Interventions: DRUG: Dexamethasone Drug delivery system (Ozurdex)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Concentrations of Risankizumab in the Breast Milk of Adult Lactating Women With Inflammatory Bowel Disease
Status: RECRUITING
Conditions: Inflammatory Bowel Disease
Interventions: PROCEDURE: Breast Milk Sampling|DRUG: Risankizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Pharmacokinetics of RTH258 in Subjects With Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Neovascular Age-Related Macular Degeneration
Interventions: DRUG: Brolucizumab 3 mg/50 μL|DRUG: Brolucizumab 6 mg/50 μL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Automated, Assistive, Non-Contact Sleep Quality Monitor for Individuals With Alzheimer's Disease
Status: NOT_YET_RECRUITING
Conditions: Alzheimer Disease|Dementia|Sleep Disturbance
Interventions: DEVICE: Non-Contact Sleep Quality Monitor System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 3 Study to Evaluate Combination Therapy With Daclatasvir and Sofosbuvir in the Treatment of HIV and Hepatitis C Virus Coinfection.
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Daclatasvir|DRUG: Sofosbuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Investigate the Pharmacokinetics (PK) of Single Doses of 200 µg, 400 µg and 2 x 400 µg of Intranasal Fentanyl Spray (INFS) in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: INFS (Intranasal Fentanyl Spray)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Live Stream of Prehospital Emergency Ultrasound in Patients With Acute Dyspnoea
Status: RECRUITING
Conditions: Echocardiography|Acute Dyspnea
Interventions: OTHER: Prehospital emergency ultrasound with tele-supervision|OTHER: Prehospital emergency ultrasound without tele-supervision
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Assess the Mildness of a Cosmetic Cleanser in Healthy Participants Using the Forearm-Controlled Application Technique (FCAT)
Status: COMPLETED
Conditions: Skin Care
Interventions: OTHER: Test Product|OTHER: Positive Control|OTHER: Reference Product|OTHER: No Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: One Week Parathyroid Hormone-related Protein (PTHrP) IV Dose Escalation Study
Status: COMPLETED
Conditions: Osteoporosis|Humoral Hypercalcemia of Malignancy|Hyperparathyroidism
Interventions: DRUG: PTHrP (1-36)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: A Plaque Test Study With LEO 35299 in Psoriasis Vulgaris
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: B LEO 35299 20 mg/g cream|DRUG: C LEO 35299 20 mg/g cream|DRUG: E LEO 35299 10 mg/g solution|DRUG: F LEO 35299 10 mg/g solution|DRUG: Daivonex® ointment|DRUG: Daivonex® ointment vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose:
Clinical trial: Whole Body Electromyostimulation and Nutritional Therapy for Patients With Chronic Liver Disease
Status: UNKNOWN
Conditions: Liver Diseases
Interventions: PROCEDURE: nutritional therapy|PROCEDURE: WB-EMS combined with nutritional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Post-operative Period
Status: COMPLETED
Conditions: Hypoplastic Left Heart Syndrome|Total Anomalous Pulmonary Venous Return|Truncus Arteriosus|Pulmonary Atresia With Ventricular Septal Defect|Transposition of the Great Arteries|Double Outlet Right Ventricle, Subpulmonary VSD|Tetralogy of Fallot|Double Outlet Right Ventricle With Subaortic Ventricular Septal Defect and Pulmonary Stenosis|Cardiopulmonary Bypass
Interventions: OTHER: Normoxia (with controlled re-oxygenation)|OTHER: Standard of care ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
Status: UNKNOWN
Conditions: Wounds and Injuries|Wound Infection|Facial Bones Fracture|Soft Tissue Injuries|Skull Fractures|Surgical Wound|Surgical Wound Infection|Wound Healing|Disturbance of Wound Healing|Wound; Head, Multiple|Wound; Head, Scalp|Wound; Head|Wound Complication|Wound Dehiscence|Wound of Skin|Wound Open|Wounds, Penetrating|Wounds, Nonpenetrating|Wounds
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: High-intensity Laser Therapy for Neck Pain
Status: RECRUITING
Conditions: Non-specific Chronic Neck Pain
Interventions: DEVICE: High-intensity laser therapy|PROCEDURE: Stretching exercise|DEVICE: Sham High-intensity laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thalidomide 100 mg/Day Versus Thalidomide 400 mg/Day in Relapse Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Orthopedic Blocking on Cervical Spine Flexion and Extension Strength
Status: UNKNOWN
Conditions: Sacroiliac Function
Interventions: PROCEDURE: Orthopedic Blocking|PROCEDURE: Trochanter Belt|OTHER: Blocking Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: NAlmefene Versus Placebo in Addition to Treatment as Usual on Craving in Behavioural Addictions
Status: RECRUITING
Conditions: Behavioural Addiction
Interventions: DRUG: Nalmefene|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenomic Contributions to Trihexyphenidyl Biotransformation and Response in Children With Dystonic Cerebral Palsy
Status: NOT_YET_RECRUITING
Conditions: Pediatric Disorder|Genetic Predisposition|Dystonia, Secondary|Dystonia|Cerebral Palsy, Dystonic-Rigid|Cerebral Palsy, Dyskinetic|Trihexyphenidyl Adverse Reaction|Pharmacogenomic Drug Interaction
Interventions: DRUG: Trihexyphenidyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Jacobson's Progressive Muscle Relaxation Technique and Audio-visual Distraction Technique in Reducing Dental Anxiety in Children During Dental Visit
Status: UNKNOWN
Conditions: Dental Anxiety
Interventions: BEHAVIORAL: jacobson's progressive muscle relaxation technique|BEHAVIORAL: audio-visual distraction technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain After Total Knee Arthroplasty: A Trial Examining Combined Adductor-canal Nerve Block and Periarticular Infiltration Versus Adductor Canal Nerve Block Versus Periarticular Infiltration
Status: COMPLETED
Conditions: Total Knee Arthroplasty|Postoperative Pain
Interventions: PROCEDURE: Adductor-canal block|PROCEDURE: Periarticular infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Famotidine Versus Placebo in Emergency Pediatric Surgery as a Risk to Postoperative Nausea and Vomiting
Status: ACTIVE_NOT_RECRUITING
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: famotidine plus10ml normal saline|OTHER: 10ml normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Effect of Adaptive Training for Balance Recovery
Status: COMPLETED
Conditions: Balance, Postural|Prevention, Accident
Interventions: BEHAVIORAL: treadmill slip perturbation|BEHAVIORAL: treadmill training placebo|BEHAVIORAL: observation training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Basil Extract (Ocimum Basilicum) in the Management of Recurrent Aphthous Stomatitis
Status: UNKNOWN
Conditions: Oral Ulcer
Interventions: DRUG: use of basil extract gel in treatment of aphthus ulcer|OTHER: muco adhesive placebo gel|OTHER: no treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Tolerability of Various Bowel Preps in Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Golytely (polyethylene glycol electrolyte lavage solution) and placebo|DRUG: split dose of Golytely (polyethylene glycol electrolyte lavage solution) + placebo|DRUG: split dose of Golytely (polyethylene glycol electrolyte lavage solution) and bisacodyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Therapeutic Plasma Exchange Followed by Convalescent Plasma Transfusion in Severe and Critically Ill COVID-19 Patients
Status: COMPLETED
Conditions: COVID-19 Pneumonia|COVID-19 Respiratory Infection|Acute Respiratory Failure|Acute Respiratory Distress Syndrome
Interventions: OTHER: Therapeutic plasma exchange
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Scapular Stabilization and Mobilizations in Sub Acromial Pain Syndrome
Status: RECRUITING
Conditions: Subacromial Impingement Syndrome
Interventions: OTHER: Experimental interventional group 1(scapular stabilization exercise therapy)|OTHER: Experimental :interventional group II (scapular mobilizations)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Groin Lymphadenectomy Extent For Metastatic Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Melanoma to the Groin Lymph Nodes
Interventions: PROCEDURE: Inguinal Lymphadenectomy|PROCEDURE: Ilio-inguinal Lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Initial Efficacy Study of the Vortx Rx for Treatment of Benign Prostatic Hyperplasia (Canada)
Status: WITHDRAWN
Conditions: Benign Prostatic Hyperplasia (BPH)
Interventions: DEVICE: Vortx Rx - Histotripsy BPH Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Umbilical Cord Milking Versus Clamping in Preterms on Cerebral Oxygenation and Ductus Arteriosus Closure
Status: COMPLETED
Conditions: Ductus Arteriosus
Interventions: PROCEDURE: Umbilical cord milking|PROCEDURE: delayed cord clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Topical Autologous Insulin Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries
Status: COMPLETED
Conditions: Corneal Epithelial Defects After Ocular Surgeries
Interventions: DRUG: Topical insulin eye drops|DRUG: Conventional postoperative eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Flexibility as a Biomarker of Adaptation to Diet and Exercise Challenges
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: High Intensity Exercise|OTHER: Low Intensity Exercise|OTHER: High Carbohydrate Beverage|OTHER: High Fat Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy, Tolerability and Safety of Azilect in Subjects With Progressive Supranuclear Palsy
Status: TERMINATED
Conditions: Progressive Supranuclear Palsy
Interventions: DRUG: Rasagiline|DRUG: Sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Written Educational Information and Phone Calls in Increasing Follow-Up Care in Hispanic Women With Abnormal Pap Smears
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: OTHER: educational intervention|OTHER: questionnaire administration|OTHER: study of socioeconomic and demographic variables|OTHER: survey administration
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Combination Therapy With NC-6004 and Gemcitabine Versus Gemcitabine Alone in Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Neoplasms
Interventions: DRUG: NC-6004|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methodological Study to Compare the Effect of Different Methods of Measuring Cat Allergy Symptoms in Patients That Have Immunized Their Cats With FEL-CMV.
Status: COMPLETED
Conditions: Hypersensitivity
Interventions: OTHER: Home-based test|OTHER: Skin test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Acupressure and Massage on Pain in Primary Dysmenorrhea
Status: COMPLETED
Conditions: Acupressure
Interventions: OTHER: The first group is acupressure and massage, the second group is massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mindfulness-Based Intervention for Latino Cancer Patients and Their Caregivers
Status: RECRUITING
Conditions: Advanced Malignant Solid Neoplasm
Interventions: BEHAVIORAL: Mindfulness Relaxation|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|OTHER: Group II (mindfulness waitlist)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Radiation Therapy and Tamoxifen in Treating Adults With Newly Diagnosed Supratentorial Glioblastoma Multiforme
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: tamoxifen citrate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement
Status: TERMINATED
Conditions: Malignant Melanoma|Carcinoma, Non-Small-Cell Lung|Brain Neoplasms, Primary|Brain Neoplasms|Malignant Neoplasms
Interventions: DRUG: PF-07284890|DRUG: Binimetinib|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Yogic Breathing Exercise for People With Amyotrophic Lateral Sclerosis
Status: RECRUITING
Conditions: Amyotrophic Lateral Sclerosis|Myasthenia Gravis
Interventions: BEHAVIORAL: yogic breathing exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Ethanol on the Pharmacokinetics of PT-150 (Formerly ORG34517) (PT150 PK Study)
Status: COMPLETED
Conditions: Potential Treatment for Alcohol Dependence-Alcohol Interaction
Interventions: DRUG: PT150|OTHER: Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Temporary Positive Expiratory Pressure (TPEP) in Chronic Hypersecretion
Status: COMPLETED
Conditions: Chronic Hypersecretions
Interventions: DEVICE: TPEP device (UNIKO)|PROCEDURE: MABT (Manually assisted breathing techniques)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Efficacy, Safety and Tolerability of AZD1152 Alone and in Combination With Low Dose Cytosine Arabinoside (LDAC)in Acute Myeloid Leukaemia (AML) Patients
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: AZD1152|DRUG: LDAC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Dose, 2-Period, 2-Treatment, 2-Way Crossover Bioequivalency Study of Ropinirole 0.25 mg Tablets Und Fasted Conditions
Status: COMPLETED
Conditions: Parkinson's Disease|Restless Leg Syndrome
Interventions: DRUG: Ropinirole Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib and Docetaxel in Treating Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: docetaxel|BIOLOGICAL: bevacizumab|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Benefits and Risks of Conversion of Existing Adolescent Kidney Transplant Recipients Aged 12 to <18 Years to a Belatacept-based Immunosuppressive Regimen as Compared to Continuation of a Calcineurin Inhibitor-based Regimen, and Their Adherence to Immunosuppressive Medications
Status: RECRUITING
Conditions: Renal Allograft Recipients
Interventions: BIOLOGICAL: Belatacept|DRUG: Tacrolimus|DRUG: Cyclosporine A|DRUG: Mycophenolate Mofetil|DRUG: Enteric Coated Mycophenolate Sodium|DRUG: Corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Lactobacillus Reuteri in Children and Adolescents With Anorexia Nervosa
Status: COMPLETED
Conditions: Anorexia Nervosa|Constipation
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri Protectis DSM17938
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Oral Sucrose During Lung Ultrasound
Status: RECRUITING
Conditions: Pain
Interventions: OTHER: 24% Sucrose solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Video Laryngoscope Versus USB Borescope in Difficult Intubation
Status: COMPLETED
Conditions: Intubation; Difficult or Failed
Interventions: DEVICE: Borescope|DEVICE: Video laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Safety and Efficacy of Glaucoma Shunt (Aurolab Artificial Drainage Implant) in Refractory Glaucoma
Status: UNKNOWN
Conditions: Glaucoma
Interventions: DEVICE: Artificial drainage implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Acupuncture Therapy Reduce the Need for Labor Induction After Postdate (Week 41)
Status: UNKNOWN
Conditions: Post-term Pregnancy (40 to 42 Weeks Gestation)
Interventions: OTHER: acupuncture treatment|OTHER: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Caterpillar Cereal for Complementary Feeding in the Democratic Republic of Congo
Status: COMPLETED
Conditions: Malnutrition|Stunting of Growth|Iron Deficiency Anemia|Neurodevelopmental Impairment|Infectious Diseases Morbidity
Interventions: DIETARY_SUPPLEMENT: Caterpillar Cereal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vitamin D in School Children
Status: RECRUITING
Conditions: Vitamin D Deficiency|Musculoskeletal Diseases|Cognitive Delay, Mild
Interventions: DIETARY_SUPPLEMENT: Oral vitamin D spray|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bone Marrow Transplantation With Specially Treated Bone Marrow in Treating Patients With Hematologic Cancer That Have Not Responded to Previous Therapy
Status: COMPLETED
Conditions: Graft Versus Host Disease|Leukemia|Lymphoma|Myelodysplastic Syndromes|Myeloma
Interventions: DRUG: cyclophosphamide|DRUG: cyclosporine|DRUG: leucovorin calcium|DRUG: methotrexate|DRUG: methylprednisolone|PROCEDURE: in vitro-treated bone marrow transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictive and Impact of Pain After 6 Months of Radiotherapy, in Head and Neck Cancer
Status: UNKNOWN
Conditions: Neuropathic Pain|Anxiety Disorder/Anxiety State|Pain, Chronic|Alcohol Use Disorder|Psychoactive Substance Use|Sleep|Symptoms and Signs|Addiction Nicotine
Interventions: OTHER: Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial to Evaluate the Safety and Immunogenicity of a Multivalent Pneumococcal Vaccine in Healthy Infants
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: Multivalent|BIOLOGICAL: 13vPnC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy and Safety of NALDEBAIN for the Treatment of Post-Laparotomy Surgery
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: Nalbuphine Sebacate|DRUG: Fentanyl Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Proficiency of Laparoscopic Vaginal Cuff Suturing After Laparoscopic Training in Surgically Naive Students
Status: COMPLETED
Conditions: Educational Problems
Interventions: PROCEDURE: Laparoscopic Simulation Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of B.Bifidum 900791 Intake in Adult With Hypolactasia and Lactose Intolerance
Status: UNKNOWN
Conditions: Lactose Intolerance
Interventions: DIETARY_SUPPLEMENT: Probiotic ice cream|DIETARY_SUPPLEMENT: Placebo ice cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Advanced MR Imaging as Predictor of Treatment Response in Newly Diagnosed Glioblastomas
Status: RECRUITING
Conditions: Adult Glioblastoma
Interventions: DEVICE: 3 Tesla magnetic resonance imaging|DEVICE: Chemical exchange saturation transfer MRI|DEVICE: Diffusion weighted MRI|DEVICE: Dynamic susceptibility contrast MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Automated Lamellar Keratectomy in Symptomatic Patients With Bullous Keratopathy
Status: COMPLETED
Conditions: Corneal Disease
Interventions: PROCEDURE: ALK (automated lamellar keratectomy)|DRUG: Mitomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Incidence and Prevalence of Cancer in People Living With HIV/AIDS at Cancer Centers in Latin America
Status: COMPLETED
Conditions: HIV Infection|Human Immunodeficiency Virus 1 Positive|Malignant Neoplasm|Recurrent Malignant Neoplasm
Interventions: OTHER: Medical Chart Review|OTHER: Survey Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Cancer-related Pain
Status: COMPLETED
Conditions: Pain, Burning|Pain, Crushing|Pain, Migratory|Pain, Radiating|Pain, Splitting
Interventions: DRUG: JNJ-42160443|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Work Outcome in People With Recent-onset Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Individual Placement and Support|BEHAVIORAL: Workplace Fundamentals Module|BEHAVIORAL: Brokered Vocational Rehabilitation|DRUG: Oral risperidone|BEHAVIORAL: Skills training group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extended-release of Octreotide (LF-PB) for the Treatment of Seroma
Status: COMPLETED
Conditions: Seroma
Interventions: DRUG: extended release of octreotide|DRUG: extended release of placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-Label Extension Study of the Phase 3 VRX-RET-E22-302 Double-Blind Trial. 115097
Status: TERMINATED
Conditions: Epilepsy
Interventions: DRUG: Retigabine (INN), Ezogabine (USAN)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 12-month, Randomized, Efficacy and Safety Study of 0.5 mg Ranibizumab vs Laser in Chinese Diabetic Macular Edema (DME) Patients
Status: COMPLETED
Conditions: Diabetic Macular Edema|Visual Impairment
Interventions: DRUG: Ranibizumab (RFB002)|PROCEDURE: Laser|DRUG: Sham injection|PROCEDURE: Sham laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Efficacy and Safety of Supaglutide in Type 2 Diabetes Patients(SUPER-1)
Status: COMPLETED
Conditions: Type2 Diabetes
Interventions: BIOLOGICAL: Supaglutide injection|OTHER: placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Peri-operative TIming of Metformin (or) Salsalate to Improve Non-cardiac Surgery Glucose Control
Status: WITHDRAWN
Conditions: Diabetes Mellitus, Type 2|Hyperglycemia|Perioperative/Postoperative Complications
Interventions: DRUG: Metformin|DRUG: Salsalate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: New Technology for Individualised, Intensive Training of Gait After Stroke- Study II
Status: COMPLETED
Conditions: Stroke|Ambulation Difficulty|Hemiparesis
Interventions: DEVICE: Hybrid Assistive Limb (HAL)|OTHER: 1st control group|OTHER: 2nd control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Limb Compartment Pressure Measurement
Status: COMPLETED
Conditions: Compartment Syndromes|Polytrauma|Burn Injury
Interventions: DEVICE: Conventional compartment pressure measurement|DEVICE: Experimental compartment pressure measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Development of a Videogame Prototype Targeting Cigarette and Marijuana Smoking, and Tobacco Product Prevention Among Young Adolescents (smokeScreen)
Status: COMPLETED
Conditions: Smoking
Interventions: DEVICE: smokeSCREEN video game
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: tDCS for Post-Stroke Cognitive Impairment
Status: NOT_YET_RECRUITING
Conditions: Stroke|Mild Cognitive Impairment
Interventions: DEVICE: Transcranial Dirrect Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of TACE on Downstaging Hepatocellular Carcinoma Beyond UCSF Criteria;
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: DEB-TACE|PROCEDURE: cTACE|DEVICE: Drug-eluting Beads|DRUG: Epirubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Dosing Of Selumetinib In Childhood NF1 Associated Tumours
Status: COMPLETED
Conditions: Neurofibromatosis Type 1|Plexiform Neurofibroma|Optic Nerve Glioma
Interventions: DRUG: Selumetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stroboscopic Vision Training in Softball
Status: ACTIVE_NOT_RECRUITING
Conditions: Sports Performance|Vision, Ocular
Interventions: DEVICE: Senaptec Strobe Glasses|OTHER: Standard softball drills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Apical Release vs Classic Holmium Laser Enucleation of the Prostate: Randomized Controlled Trial Comparing Post-Operative Incontinence Rates and Surgical Outcomes
Status: UNKNOWN
Conditions: Benign Prostatic Hyperplasia
Interventions: PROCEDURE: EAR HoLEP|PROCEDURE: Classic HoLEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study Investigating Repeat Doses Of A New Medication (GSK159797) In Asthmatic Patients
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK159797 (10, 15, and 20mcg)|DRUG: salbutamol|DRUG: salmeterol 50mcg|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Conventional and CAD/CAM Complete Dentures Designed Based on Neutral Zone Concept
Status: COMPLETED
Conditions: Missing Teeth|Dentures
Interventions: DEVICE: Heat Cured Conventional Polymethylmethacrylate Complete Removable Dentures based on neutral zone concept|DEVICE: CAD/CAM Milled Methacrylate Complete Removable Dentures based on neutral zone concept.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Emotional Arousal in Food Preference and Taste
Status: COMPLETED
Conditions: Obesity|Food Craving|Food Consumption
Interventions: BEHAVIORAL: Stress Imagery|BEHAVIORAL: Food Cue Imagery|BEHAVIORAL: Neutral-Relaxing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Mesalazine Therapy in Patients With Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Mesalazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of a Mobile Application Designed for Adults at Risk of Developing Diabetes
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus Risk|PreDiabetes
Interventions: OTHER: PREDIABE-TR mobile app.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Early Detection of Myocardial Work Impairment in Obesity II(EARLY-MYO-OBESITY-II)
Status: RECRUITING
Conditions: Overweight and Obesity
Interventions: DIAGNOSTIC_TEST: Myocardial work was estimated from left ventricular pressure-strain loop derived from speckle tracking echocardiography and non-invasive brachial artery cuff pressure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Entecavir Maleate Tablets in Chinese Patients With Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: Entecavir maleate tablets|DRUG: blank Baraclude tablets|DRUG: Blank maleate entecavir tablets|DRUG: Baraclude tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Community Health Nurse/Peer Counselor Program to Help Low-Income Women Breastfeed Longer
Status: COMPLETED
Conditions: Breastfeeding Rates
Interventions: BEHAVIORAL: Usual Care|BEHAVIORAL: Community Health Nurse/Peer Councelor Team
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of a Calorie Restricted, Very Low Fat Plant-based Diet and Multi-component Exercise Program on Metabolic Health
Status: COMPLETED
Conditions: Obesity|Insulin Resistance
Interventions: OTHER: Weight loss with very low fat plant-based diet and regular exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD5718 After Single and Multiple Ascending Dose Administration to Healthy Japanese Men
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: AZD5718 oral suspension|OTHER: Placebo matching AZD5817 oral suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate if Dexmedetomidine Infusion Provides Renal Protection in Patients Undergoing Coronary Artery Bypass Graft
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: DRUG: Dexmedetomidine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Metabolomic Evaluation of Psycho-surgical Synergy on Body Image Restoration After Breast Cancer
Status: RECRUITING
Conditions: Psychological
Interventions: OTHER: psychological-clinical intervention with three days of expressive writing by Pennebaker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Scleral Buckling for Retinal Detachment Prevention in Genetically Confirmed Stickler Syndrome
Status: NOT_YET_RECRUITING
Conditions: Stickler Syndrome
Interventions: PROCEDURE: Encircling scleral buckle surgical procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparative Validation of the Growth Hormone Releasing Hormone and Arginine Test for the Diagnosis of Adult Growth Hormone Deficiency
Status: COMPLETED
Conditions: Growth Hormone Deficiency
Interventions: OTHER: GHRH+Arg, GHRH+Arg, ITT|OTHER: ITT, ITT, GHRH+Arg.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: "Potential Effects of Virtual Reality Technology on the Treatment of Migraine-Type Headaches"
Status: COMPLETED
Conditions: Migraine Disorders|Virtual Reality
Interventions: DEVICE: Virtual Reality
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Rehabilitation After Cardiac Surgery in Patients at Risk of Respiratory Complications. Effects of a Continuous Bi-laterosternal Infusion of Ropivacaine Through Multihole Catheters
Status: COMPLETED
Conditions: Scheduled Cardiac Surgery|Sternotomy|Elderly Patients|Obesity|Chronic Bronchitis
Interventions: DRUG: Ropivacaine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Extending Sleep to Reverse Metabolic Syndrome in Middle-aged Adults: Acceptability and Feasibility of a Sleep Intervention
Status: COMPLETED
Conditions: Sleep|Metabolic Syndrome
Interventions: BEHAVIORAL: Self- management for adequate sleep intervention (SASI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacokinetic Study of OPC-1085EL Ophthalmic Solution in Healthy Male Adult Volunteers
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: OPC-1085EL ophthalmic solution|DRUG: Carteolol long-acting ophthalmic solution|DRUG: Latanoprost ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: A Clinical Study on the Efficacy and Safety of Paclitaxel Polymer Micelles and Cisplatin Combined With Cadonilimab as a Neoadjuvant Therapy for Locally Advanced Esophageal Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Esophageal Squamous Cell Carcinoma|Neoadjuvant Therapy
Interventions: DRUG: paclitaxel polymer micelles and cisplatin combined with Cadonilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Evaluate the Safety and Efficacy of ABP-450 in the Treatment of Cervical Dystonia
Status: COMPLETED
Conditions: Cervical Dystonia
Interventions: DRUG: ABP-450|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eight-Week Efficacy & Safety Study of Brisdelle™ (Formerly Known as Mesafem) in the Treatment of Vasomotor Symptoms Associated With Menopause
Status: COMPLETED
Conditions: Hot Flashes
Interventions: DRUG: Brisdelle (paroxetine mesylate)|DRUG: Sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trigger Point Dry Needling vs Trigger Point Dry Needling With Intramuscular Electrical Stimulation
Status: COMPLETED
Conditions: Sub-acute and Chronic Low Back Pain
Interventions: DEVICE: trigger point dry needling|DEVICE: Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmaceutical Care in Ambulatory Hemodialysis Patients
Status: UNKNOWN
Conditions: Medication Adherence|Chronic Renal Diseases|Renal Failure Chronic Requiring Hemodialysis
Interventions: OTHER: Pharmaceutical care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: