pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Dynamics of Stroke Volume and Cardiac Output During Parabolic Flight, and Its Relationship to Intravascular Volume
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: Parabolic flight|OTHER: plasma volume measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Work Place Adjusted Intelligent Physical Exercise Reducing Musculoskeletal Pain in Shoulder and Neck (VIMS) - Industrial Workers
Status: COMPLETED
Conditions: Non-specific Pain of the Neck and Shoulder
Interventions: OTHER: Work Place Adjusted Intelligent Physical Exercise Reducing Musculoskeletal Pain in Shoulder and Neck
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Efficacy and Safety of Paricalcitol in the Treatment of Chronic Kidney Disease With Secondary Hyperparathyroidism
Status: UNKNOWN
Conditions: Secondary Hyperparathyroidism
Interventions: DRUG: Paricalcitol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Dasatinib (BMS-354825) for Androgen-deprived Progressive Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: dasatinib|DRUG: dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ixekizumab (LY2439821) in Children With Juvenile Idiopathic Arthritis Categories of Enthesitis-related Arthritis (Including Juvenile Onset Ankylosing Spondylitis) and Juvenile Psoriatic Arthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Juvenile Psoriatic Arthritis|Enthesitis Related Arthritis
Interventions: DRUG: Ixekizumab|DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the CochSyn Test Prototype to Measure Cochlear Synaptopathy
Status: RECRUITING
Conditions: Hearing Loss, Sensorineural|Cochlear Synaptopathy|Cochlear Hearing Loss
Interventions: DEVICE: CochSyn test prototype|DEVICE: Universal Smart Box (USB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Assess the Safety, Tolerability, and Efficacy of IONIS-GHR-LRx Administered in Patients With Acromegaly
Status: COMPLETED
Conditions: Acromegaly
Interventions: DRUG: IONIS-GHR-LRx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glove Perforation When Using Blunt Verses Sharp Needles in Cesarean Delivery
Status: COMPLETED
Conditions: Cesarean Delivery|Glove Perforation
Interventions: OTHER: Blunt tipped needle|OTHER: Sharp needles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial to Evaluate the Efficacy, Safety and Tolerability of Subcutaneous TRV250
Status: TERMINATED
Conditions: Migraines
Interventions: DRUG: Part A: TRV250-20mg/ml|DRUG: Placebo|DRUG: Part B: TRV250 Dose 1|DRUG: Part B: TRV250 Dose 2|DRUG: Part B: TRV250 Dose 3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Biological Therapy in Treating Women With Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: cytokine therapy|BIOLOGICAL: sargramostim|DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: thiotepa|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Intervention in Habit, Automatic Affective Evaluations and Physical Activity Among University Students
Status: RECRUITING
Conditions: Physical Inactivity|Sedentary Behavior
Interventions: BEHAVIORAL: LifelongU|BEHAVIORAL: Physical education
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Ibrutinib in Relapsed and Refractory T-cell Lymphoma
Status: COMPLETED
Conditions: T-cell Lymphoma|Relapsed and Refractory T-cell Lymphoma
Interventions: DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resveratrol and Type 2 Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: placebo|DIETARY_SUPPLEMENT: resveratrol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Gaseous Cryotherapy on Knee ROM After TKA: A Feasibility Study
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Cryoton ™|DEVICE: Control ice bag
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Y90 Radioembolization Prior to Surgical Resection or Radiofrequency for Hepatocellular Carcinoma in Cirrhotic Liver
Status: TERMINATED
Conditions: Hepatocellular Carcinoma|Liver Cirrhosis
Interventions: DEVICE: Sirsphere trans-arterial radioembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Gender and Pubertal Status on Human Plasmacytoid Dendritic Cells. PLASMACYTOKID
Status: TERMINATED
Conditions: Innate Immune Responses
Interventions: BIOLOGICAL: Blood Plasmacytoid dendritic cells (pDCs) absolute number
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: An Exploratory Study of Immunotherapy Combined With Anlotinib and Chemotherapy in Perioperative Treatment of LAGC
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Penpulimab combined with Anlotinib Hydrochloride Capsules and chemotherapy;Cadonilimab combined with Anlotinib Hydrochloride Capsules and chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Multiple-dose of JS004 in Subject With HNC
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinom|Nasopharyngeal Carcinoma
Interventions: BIOLOGICAL: JS004 , Recombinant humanized IgG4k monoclonal antibody specific to BTLA for injection Intravenous infusion|BIOLOGICAL: JS004 , Recombinant humanized IgG4k monoclonal antibody specific to BTLA for injection Intravenous infusion|BIOLOGICAL: JS001 and JS004
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on Silk Sericin Wound Dressing for Split-thickness Skin Graft Donor Sites Treatment
Status: COMPLETED
Conditions: Late Complication From Skin Graft|Infection of Skin Donor Site|Impaired Wound Healing|Pain, Intractable
Interventions: DEVICE: Sericin scaffold
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: BIOLOGICAL: EP-2101|BIOLOGICAL: incomplete Freund's adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of a New Drug Treatment for Acne
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: 1.2% JNJ 10229570-AAA|DRUG: 2.4% JNJ 10229570-AAA|DRUG: 3.6% JNJ 10229570-AAA|OTHER: Vehicle control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Different Types of Anaesthesia on Intraocular Pressure During Lumbar Disc Herniation Surgery
Status: COMPLETED
Conditions: Anesthesia|Disk Herniated Lumbar|Intraocular Pressure
Interventions: OTHER: Spinal Anesthesia Group|OTHER: Desflurane Group|OTHER: Propofol Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of the Effects of Carboxytherapy and Radiofrequency on Skin Rejuvenation
Status: COMPLETED
Conditions: Skin Aging|Skin Rejuvenation
Interventions: OTHER: Carboxytherapy|OTHER: Radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Antibiotic Efficacy in Pneumonitis Following Paraffin (Kerosene) Ingestion in Children
Status: COMPLETED
Conditions: Kerosene Pneumonitis
Interventions: DRUG: Amoxicillin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Citizen-targeted Evidence-based Resources
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases|Irritable Bowel Syndrome
Interventions: OTHER: Structured guide|OTHER: List
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cilostazol and Methotrexate in Rheumatoid Arthritis
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Cilostazol|DRUG: Methotrexate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a Single Dose or Two Doses of a Trivalent Inactivated Influenza Vaccine Produced at Shenzhen, China
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Shenzhen trivalent influenza vaccine (split virion, inactivated) North Hemisphere (NH) formulation|BIOLOGICAL: Shenzhen trivalent influenza vaccine (split virion, inactivated) North Hemisphere (NH) formulation|BIOLOGICAL: Shenzhen trivalent influenza vaccine (split virion, inactivated) North Hemisphere (NH) formulation|BIOLOGICAL: Shenzhen trivalent influenza vaccine (split virion, inactivated) North Hemisphere (NH) formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Aggressive Fever Control With Intravenous Ibuprofen After Non-traumatic Brain Hemorrhage
Status: TERMINATED
Conditions: Fever
Interventions: DRUG: Intravenous Ibuprofen|DRUG: Acetaminophen (Standard of Care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Participants With Type 2 Diabetes Mellitus (AWARD-3)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Metformin|DRUG: LY2189265|DRUG: Placebo (oral)|DRUG: Placebo (subcutaneous)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Ablative Radiotherapy in Locally Advanced Non Small Cell Lung Cancer
Status: COMPLETED
Conditions: Locally Advanced Lung Non-Small Cell Carcinoma
Interventions: RADIATION: Stereotactic Ablative Radiotherapy in Unresectable Locally Advanced Non-Small Cell Lung Cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of AEMCOLO (Rifamycin SV MMX) in the Treatment of Small Intestinal Bacterial Overgrowth (SIBO)
Status: UNKNOWN
Conditions: Small Intestinal Bacterial Overgrowth|Gastrointestinal Disease|Gastrointestinal Infection
Interventions: DRUG: AEMCOLO (Rifamycin SV MMX)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise MRI to Evaluate Cardiorespiratory Fitness in Children With Heart Disease
Status: NOT_YET_RECRUITING
Conditions: Pediatric ALL|Congenital Heart Disease|Heart Transplantation
Interventions: DIAGNOSTIC_TEST: Exercise cardiac MRI Assessment|DIAGNOSTIC_TEST: Cardiopulmonary Exercise Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Post-prandial Glycaemic Controlling Effects of BSG in Singapore Adults With Metabolic Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Metabolic Syndrome|Diabetes|Diet Modification
Interventions: DIETARY_SUPPLEMENT: autoclaved BSG-containing biscuits|DIETARY_SUPPLEMENT: bio-transformed BSG-containing biscuits|DIETARY_SUPPLEMENT: control biscuits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Efficacy and Safety of Risperidone ISM® in Patients With Acute Schizophrenia: Open Label Extension
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Risperidone ISM 75 mg|DRUG: Risperidone ISM 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of 2 Doses of VAQTA™ in Healthy Children 12 to 23 Months of Age (V251-069)
Status: COMPLETED
Conditions: Hepatitis A Virus Infection
Interventions: BIOLOGICAL: Hepatitis A Vaccine, Purified Inactivated (VAQTA™)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Thrombectomy in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: PROCEDURE: Thrombectomy|PROCEDURE: Primary angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Look at Safety and Tolerability of NNC0582-0001, How it is Transported Throughout the Body and How it Works in Healthy Adults
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: NNC0582-0001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DS-5565 Phase III Study for Renal Impairment in Japanese Subjects
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathic Pain|Post-herpetic Neuralgia
Interventions: DRUG: DS-5565
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT of IV Dexamethasone to Prevent Relapse in the Treatment of Migraine in a Paediatric ED
Status: RECRUITING
Conditions: Migraine
Interventions: DRUG: Dexamethasone group|DRUG: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Working Memory Functioning in Alzheimer's Disease and Vascular Dementia
Status: NOT_YET_RECRUITING
Conditions: Alzheimer Disease|Vascular Dementia|Mixed Dementias
Interventions: BEHAVIORAL: Complex span task|DIAGNOSTIC_TEST: Clinical neuropsychological assessment|DIAGNOSTIC_TEST: Clinical neurospychological assessement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Interruption of Maternal-to-Infant Transmission of Hepatitis B by Means of Hepatitis B Immune Globulin
Status: COMPLETED
Conditions: Hepatitis B|Hepatitis, Viral, Human|Liver Diseases
Interventions: DRUG: immunoglobulins, intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Do Xanthine Oxidase Inhibitors Reduce Both Left Ventricular Hypertrophy and Endothelial Dysfunction in Cardiovascular Patients With Renal Dysfunction?
Status: COMPLETED
Conditions: Kidney Disease|Left Ventricular Hypertrophy
Interventions: DRUG: Placebo|DRUG: Allopurinol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain Metastases
Status: RECRUITING
Conditions: Brain Metastases|Tumor
Interventions: DRUG: Pembrolizumab|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prasugrel for Prevention of Early Saphenous Vein Graft Thrombosis
Status: COMPLETED
Conditions: Coronary Artery Bypass
Interventions: DRUG: Prasugrel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Safety and Efficacy Evaluation of AL8326 in ≥2nd Line SCLC
Status: RECRUITING
Conditions: Small Cell Lung Cancer
Interventions: DRUG: AL8326 low dose group|DRUG: AL8326 middle dose group|DRUG: AL8326 high dose group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: American Ginseng in Treating Patients With Cancer-Related Fatigue
Status: COMPLETED
Conditions: Fatigue|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DIETARY_SUPPLEMENT: American ginseng|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study Evaluating the Effects of GLPG3970 Given as an Oral Treatment for 12 Weeks in Adults With Active Primary Sjögren's Syndrome (pSS)
Status: TERMINATED
Conditions: Primary Sjögren Syndrome
Interventions: DRUG: GLPG3970|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characterization of the Immunometabolic Signature in Long COVID-19.
Status: NOT_YET_RECRUITING
Conditions: Long COVID
Interventions: BIOLOGICAL: Blood sample (at inclusion and 6 months later)|OTHER: Patient questionnaires (at inclusion and 6 months later)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Non-warfarin Oral AntiCoagulant Resumption After Gastrointestinal Bleeding in Atrial Fibrillation Patients
Status: RECRUITING
Conditions: Upper Gastrointestinal Bleeding
Interventions: OTHER: restart NOAC very early|OTHER: restart NOAC early
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Conventional Versus Ultrasound-guided Transbronchial Needle Aspiration for the Diagnosis of Hilar/Mediastinal Lymphadenopathies
Status: COMPLETED
Conditions: Mediastinal Lymphadenopathy|Hilar Lymphadenopathy|Lymphoma|Lung Neoplasms|Sarcoidosis
Interventions: DEVICE: EBUS-TBNA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Physical Activity Promotion for Breast and Endometrial Cancer Survivors
Status: ACTIVE_NOT_RECRUITING
Conditions: Physical Activity|Breast Cancer Survivors|Endometrial Cancer Survivors
Interventions: OTHER: Base intervention-Fitbit with EHR integration|OTHER: Coaching Calls|OTHER: Online Gym
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of HB002.1T Plus Chemotherapy in Subjects With Solid Tumor
Status: UNKNOWN
Conditions: Solid Tumor
Interventions: DRUG: HB002.1T|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Paclitaxel|DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lovastatin in Treating Patients At High Risk of Melanoma
Status: COMPLETED
Conditions: Precancerous Condition|Stage 0 Melanoma|Stage I Melanoma|Stage II Melanoma
Interventions: DRUG: lovastatin|OTHER: placebo|PROCEDURE: biopsy|PROCEDURE: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of External Drainage of the Main Pancreatic Duct and Common Bile Duct on Pancreatic Fistula Following Pancreaticoduodenectomy
Status: RECRUITING
Conditions: Pancreaticoduodenectomy
Interventions: PROCEDURE: Main pancreatic duct and biliary duct external drainage|PROCEDURE: Main pancreatic duct and biliary duct internal drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Trial Evaluating Cosentyx (Secukinumab) for Patients With Moderate-to-Severe Hidradenitis Suppurativa
Status: COMPLETED
Conditions: Hidradenitis Suppurativa
Interventions: BIOLOGICAL: secukinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotics and Antibiotic Associated Diarrhea in Pediatric Complicated Appendicitis
Status: COMPLETED
Conditions: Appendicitis|Appendicitis; Perforation
Interventions: DIETARY_SUPPLEMENT: Lactobacillus rhamnosus GG (LGG) Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Patients With Acute Sickle Cell Crises?
Status: COMPLETED
Conditions: Sickle Cell Anemia Crisis
Interventions: DRUG: Acetaminophen|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Metformin Component of Fixed Dose Combination (FDC) Immediate Release (IR) Tablet of Canagliflozin and Metformin Compared to Metformin IR Tablet Co-administered With Canagliflozin in Healthy Fed and Fasted Participants
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Canagliflozin and Metformin Immediate Release (IR) Fixed Dose Combination [FDC]|DRUG: Canagliflozin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking WHO Step III Analgesics But Showing a Lack of Tolerability.
Status: TERMINATED
Conditions: Chronic Pain|Osteoarthritis
Interventions: DRUG: Tapentadol PR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Function and Electrocardiogram (ECG) During Hypoglycemia and Blockade of the Renin-angiotensin System
Status: COMPLETED
Conditions: Type 1 Diabetes|Hypoglycemia
Interventions: DRUG: Angiotensin II receptor antagonists (Candesartan)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Mechanical vs. Radiofrequency-Based Debridement in the Treatment of Articular Cartilage Lesions
Status: TERMINATED
Conditions: Chondral Lesion Plus Partial Medial Meniscectomy
Interventions: DEVICE: Mechanical Debridement|DEVICE: RF-Based Debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Population Pharmacokinetics and Dosage Individualization of Oral Pulmonary Vasodilators in PPHN
Status: UNKNOWN
Conditions: Persistent Pulmonary Hypertension of the Newborn
Interventions: DRUG: Bosentan Tablets|DRUG: Sildenafil Tablet|DRUG: Tadalafil Tablets
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Resistance Training and Hydrolyzed Collagen Supplementation in Healthy Young Adults
Status: COMPLETED
Conditions: Healthy Participants|Nutrition|Exercise Training
Interventions: DIETARY_SUPPLEMENT: Resistance training with hydrolyzed collagen ingestion in healthy young men|DIETARY_SUPPLEMENT: Resistance training with hydrolyzed collagen ingestion in healthy young women
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of XL784 in Patients With Albuminuria Due to Diabetic Nephropathy
Status: COMPLETED
Conditions: Albuminuria|Diabetic Nephropathy
Interventions: DRUG: XL784
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment Outcome of Combined Virtual Tic Training in Children and Adolescents With a Chronic Tic Disorder
Status: UNKNOWN
Conditions: Chronic Tic Disorder
Interventions: BEHAVIORAL: Combined HRT and ERP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Herb-partitioned Moxibustion Plus Lifestyle Modification Treatment for Simple Obesity
Status: UNKNOWN
Conditions: Obesity
Interventions: DEVICE: Heat application at acupoints|DEVICE: Medicated plaster at acupoints|DEVICE: Herb-partitioned moxibustion at acupoints
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicentre, Randomised, Double-blind, Parallel Group, Placebo-controlled, Time-to-first Asthma Exacerbation Phase III Efficacy and Safety Study of Benralizumab in Paediatric Patients With Severe Eosinophilic Asthma (DOMINICA)
Status: RECRUITING
Conditions: Asthma
Interventions: DRUG: Benralizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Performance of AI in Evaluating Breast MRI Performed With Dose Reduction
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Benign Tumor|Breast Malignant Tumor
Interventions: DRUG: Standard of Care (SOC) gadolinium Breast MRI|DRUG: reduced 1/4 dose gadolinium Breast MRI with Artificial Intelligence (AI) to aid in evaluation.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: BOND Study: the Benefit Of Night Splinting in Dupuytrens'
Status: WITHDRAWN
Conditions: Dupuytren Contracture
Interventions: DEVICE: Thermoplastic Hand Splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Vitamin D in Pediatric Crohn's Disease ( ViDiPeC-2 )
Status: RECRUITING
Conditions: Crohn Disease
Interventions: DRUG: vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, Tolerability and Pharmacokinetics of SUN13837 to Treat Acute Stroke
Status: WITHDRAWN
Conditions: Stroke
Interventions: DRUG: SUN13837|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modulatory Effects of Multichannel tDCS During Prolonged Experimental Pain
Status: COMPLETED
Conditions: Prolonged Pain|Neuroplasticity|Brain Modulation
Interventions: DEVICE: transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tamibarotene Plus Azacitidine in Participants With Newly Diagnosed RARA-positive Higher-Risk Myelodysplastic Syndrome
Status: RECRUITING
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Tamibarotene|DRUG: Placebo|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-cancer Potentiality of Saffron Against Hepatocellular Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DIETARY_SUPPLEMENT: Saffranal|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Treatment Change in Panic Disorder and Agoraphobia
Status: COMPLETED
Conditions: Panic Disorder With Agoraphobia
Interventions: BEHAVIORAL: Cognitive Therapy|BEHAVIORAL: Capnometry-Assisted Respiratory Training|BEHAVIORAL: In-vivo exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Moisturizing Effect of Two Dexpanthenol Formulations
Status: COMPLETED
Conditions: Skin Abnormalities
Interventions: DRUG: Dexpanthenol foam spray, new formulation|DRUG: Dexpanthenol foam spray, old formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SMILE: Clinical Trial to Evaluate Mindfulness as Intervention for Racial and Ethnic Populations During COVID-19
Status: RECRUITING
Conditions: Anxiety|COVID-19 Pandemic
Interventions: BEHAVIORAL: Mindfulness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Horizontal Mattress vs. Interrupted Suture in Surgical Techniques of Pancreaticojejunostomy
Status: UNKNOWN
Conditions: Patients Who Undergo Pancreatoduodenectomy
Interventions: PROCEDURE: pancreaticojejunostomy with horizontal mattress suture|PROCEDURE: pancreaticojejunostomy with interrupted suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Extension Study of Pitavastatin in Patients With Primary Hypercholesterolemia or Combined Dyslipidemia
Status: COMPLETED
Conditions: Hypercholesterolemia|Dyslipidemia
Interventions: DRUG: Pitavastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study of Oral Fluorescite to Confirm the Authenticity of Point of Care Urine Samples
Status: COMPLETED
Conditions: Urine Sample Authenticity
Interventions: DRUG: fluorescein sodium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Pediatric Prehospital Airway Resuscitation Trial
Status: RECRUITING
Conditions: Heart Arrest, Out-Of-Hospital|Wounds and Injuries|Respiratory Insufficiency in Children|Child, Only|Critical Illness
Interventions: DEVICE: BVM|DEVICE: SGA|DEVICE: ETI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Observational, Prospective Study of Patients With Chondral and/or Osteochondral Defects of the Knee Treated With NAMIC
Status: UNKNOWN
Conditions: Chondral Defect|Osteochondral Defect
Interventions: BIOLOGICAL: NAMIC: nanofractured autologous matrix-induced chondrogenesis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Early Diagnosis of Anastomotic Leakage After Colorectal Surgery: Italian ColoRectal Anastomotic Leakage Study Group.
Status: UNKNOWN
Conditions: Anastomotic Leak|Colorectal Surgery
Interventions: DIAGNOSTIC_TEST: Dutch score|DIAGNOSTIC_TEST: Serum C-reactive Protein|DIAGNOSTIC_TEST: serum Procalcitonin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Automated Insulin Delivery for Inpatients With Dysglycemia
Status: NOT_YET_RECRUITING
Conditions: Type 1 Diabetes|Type 2 Diabetes
Interventions: DEVICE: AID system with Remote Real-Time CGM|COMBINATION_PRODUCT: Standard of Care Insulin Therapy + CGM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Analgesic Effect Between the Motor Cortex Stimulation and the Trans-spinal Stimulation in the Algoneurodystrophy.
Status: COMPLETED
Conditions: Algoneurodystrophy
Interventions: DEVICE: rTMS|DEVICE: tDCS|DEVICE: tsDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanical Respiratory/Circulatory Support in Patients With Pulmonary Thrombectomy
Status: RECRUITING
Conditions: Pulmonary Embolism and Thrombosis|Extracorporeal Membrane Oxygenation|Percutaneous Pulmonary Thrombectomy
Interventions: PROCEDURE: Percutaneous pulmonary thrombectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pazopanib (GW786034) In Subjects With Relapsed Or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: GW786034
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DAPHNe: Paclitaxel/Trastuzumab/Pertuzumab in HER2-Positive BC
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Paclitaxel|DRUG: Trastuzumab|DRUG: Pertuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ondansetron With/Out Dexamethasone to Prevent Vomiting in Patients Receiving Radiation to the Upper Abdomen
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: dexamethasone|DRUG: ondansetron|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SOLIDARITY Finland Plus Long-COVID
Status: RECRUITING
Conditions: Covid19|Coronavirus Disease 2019|SARS-CoV-2 Acute Respiratory Disease
Interventions: DRUG: Imatinib|DRUG: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of Lithium With Oxaliplatin and Capecitabine in Advanced Oesophago-Gastric or Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Neoplasms|Stomach Neoplasm|Esophageal Neoplasms
Interventions: DRUG: Lithium|DRUG: Oxaliplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Metformin Versus Empagliflozin on Chronic Kidney Disease Progression
Status: RECRUITING
Conditions: Renal Insufficiency, Chronic
Interventions: DRUG: Metformin|DRUG: Empagliflozin|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Complex All-comers and Patients With Diabetes or Prediabetes, Treated With Xience Sierra Everolimus-eluting Stents
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Coronary Syndrome|Angina Pectoris|Angina, Unstable|Myocardial Infarction|Coronary Artery Disease|Coronary Stenosis|Coronary Restenosis
Interventions: DEVICE: Percutaneous coronary intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Co-ingestion of Rice Bran Soymilk or Plain Soymilk With White Bread: Effects on the Glycaemic and Insulinaemic Response
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Control|OTHER: Control|OTHER: Ricebran soybean milk|OTHER: Soybean milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Repurposing Valsartan May Protect Against Pulmonary Hypertension
Status: RECRUITING
Conditions: Pulmonary Arterial Hypertension|Right Heart Failure|Right Ventricular Dysfunction|Pulmonary Vascular Disorder
Interventions: DRUG: Valsartan 40 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of RC48-ADC Administered Intravenously to Patients With HER2-Positive Metastatic Breast Cancer With or Without Liver Metastases
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Neoplasms|Breast Diseases|Capecitabine|HER2-positive Breast Cancer|HER2 Positive Breast Carcinoma|HER2-positive Advanced Breast With Liver Metastases
Interventions: DRUG: RC48-ADC|DRUG: Lapatinib|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of New Malaria Vaccine Candidate ChAd63 CS Administered Alone and With MVA CS
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: ChAd63 CS|BIOLOGICAL: ChAd63 CS, MVA CS|BIOLOGICAL: ChAd63 CS|BIOLOGICAL: ChAd63, MVA CS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Diabetic Macular Edema With Aflibercept in Subjects Previously Treated With Ranibizumab or Bevacizumab
Status: COMPLETED
Conditions: Diabetic Retinopathy|Macular Edema
Interventions: DRUG: aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regorafenib in Treating Patients With Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction Who Have Completed Chemoradiation Therapy and Surgery
Status: TERMINATED
Conditions: Adenocarcinoma of the Gastroesophageal Junction|Stage IIB Esophageal Adenocarcinoma|Stage IIIA Esophageal Adenocarcinoma|Stage IIIB Esophageal Adenocarcinoma|Stage IIIC Esophageal Adenocarcinoma
Interventions: OTHER: Placebo|DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Polyvalent Immunoglobulin in COVID-19 Related ARds
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome|COVID-19
Interventions: DRUG: Human immunoglobulin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety Extension Study of ACTIMMUNE® (Interferon γ-1b) in Children and Young Adults With Friedreich's Ataxia
Status: COMPLETED
Conditions: Friedreich's Ataxia
Interventions: DRUG: interferon γ-1b
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Adverse Events and Change in Disease Activity of Intramuscular AGN-151586 Injection in Toxin-Naïve Adult Participants With Glabellar Lines
Status: COMPLETED
Conditions: Glabellar Lines
Interventions: DRUG: AGN-151586|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Length of Effect of Extended Release Aspirin on Platelets in Patients With Diabetes and Heart Disease
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DRUG: Aspirin|DRUG: Durlaza™
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Repeated Injections of Higher Doses of Botulinum Toxin on Lower Limb of Spastic Hemiplegic Patients on Gait.
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: Xeomin Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Faecal Loss of Vedolizumab and Its Role in Influencing Serum Drug Levels, Outcomes and Response in Ulcerative Colitis
Status: UNKNOWN
Conditions: Ulcerative Colitis
Interventions: BIOLOGICAL: Vedolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-finding Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of SNB-101(SN-38) in Patients With Tumors
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer|Breast Cancer|Pancreas Cancer|Ovarian Cancer|Small-cell Lung Cancer|Gastric Cancer|Head and Neck Cancer
Interventions: DRUG: SNB-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Whey Protein Micelles and Thermogenesis in Overweight Subjects
Status: COMPLETED
Conditions: Overweight
Interventions: OTHER: Control (WPM 0)|OTHER: WPM 30|OTHER: WPM 50|OTHER: MC 50
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Study to Assess Safety, Tolerability and Pharmacokinetics of Single Rising Inhaled Doses of BI 1744 CL in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1744 CL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study the Safety and Efficacy of PTK 0796 in Patients With Complicated Skin and Skin Structure Infection (CSSSI)
Status: TERMINATED
Conditions: Skin Diseases, Infectious
Interventions: DRUG: PTK 0796|DRUG: linezolid|DRUG: moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Social Cognition,Attentional Network and Nicotine Drug Dependency - A Pharmacological Clinical Trail
Status: COMPLETED
Conditions: Tobacco Use Disorder|Schizophrenia
Interventions: DRUG: nicotine nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of tDCS on Motor Functions and Brain Activity in Acute Stroke Patients
Status: COMPLETED
Conditions: Stroke, Acute
Interventions: DEVICE: Transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Young Woman's Reach Project: Trial of an Intervention to Impact Contraceptive Behavior, Unintended Pregnancy, and Sexually Transmitted Infections (STIs) Among Adolescent Females
Status: COMPLETED
Conditions: Contraceptive Behavior|Sexually Transmitted Diseases
Interventions: BEHAVIORAL: follow-up phone counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate a Computerized Stethoscope Called ©Voqx to Diagnose Heart Disease
Status: COMPLETED
Conditions: Isolated Aortic Stenosis|Mitral Regurgitation
Interventions: DEVICE: ©VoqX stethoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dosage of Serum Tryptase Levels in a Population of Premature Newborns to Evaluate Mast Cell Activity
Status: COMPLETED
Conditions: Premature Newborns
Interventions: BIOLOGICAL: Additional taking blood
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Low Load, High-repetitive Elastic Band Resistance Training in COPD
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|Healthy
Interventions: OTHER: Single limb|OTHER: Two limb
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Randomized Clinical Trial to Assess the Safety of Teleconsultation
Status: RECRUITING
Conditions: Various Clinical Conditions Commonly Followed up in a Secondary Hospital
Interventions: OTHER: Face-to-face appointment|OTHER: Remote consultation (telephone or video consultation mode)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning
Status: COMPLETED
Conditions: Retinal Artery Occlusion|Retinal Vein Occlusion
Interventions: PROCEDURE: Remote ischemic conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of Creatine Supplementation and Exercise on Muscle and Bone
Status: COMPLETED
Conditions: Osteoporosis|Sarcopenia
Interventions: DIETARY_SUPPLEMENT: creatine monohydrate|DIETARY_SUPPLEMENT: sugar placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION