pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Onalespib and Paclitaxel in Treating Patients With Advanced Triple Negative Breast Cancer
Status: TERMINATED
Conditions: Advanced Breast Carcinoma|Metastatic Breast Carcinoma|Stage III Breast Cancer AJCC v7|Stage IIIA Breast Cancer AJCC v7|Stage IIIB Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7|Stage IV Breast Cancer AJCC v6 and v7|Triple-Negative Breast Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Onalespib|DRUG: Paclitaxel|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TY-9591 in Advanced Non-small Cell Lung Cancer(NSCLC) Patients With EGFR Positive Mutation
Status: COMPLETED
Conditions: NSCLC
Interventions: DRUG: TY-9591(10mg,40mg) qd. po
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Video-Assisted Breastfeeding Education
Status: COMPLETED
Conditions: Pregnancy Related|Breastfeeding|Breastfeeding, Exclusive|Educational Problems
Interventions: BEHAVIORAL: educational group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Real-Time Muscle Pressure Measurements in Patients at Risk for Acute Compartment Syndrome
Status: UNKNOWN
Conditions: Acute Compartment Syndrome
Interventions: DEVICE: Measurement of the Intra-Compartmental Pressure with the MY01 device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Novel Use of Gamification With Alternative Goal-setting Experiences
Status: COMPLETED
Conditions: Atherosclerotic Cardiovascular Disease
Interventions: BEHAVIORAL: Choice + Immediate|BEHAVIORAL: Choice + Gradual|BEHAVIORAL: Assigned + Immediate|BEHAVIORAL: Assigned + Gradual|BEHAVIORAL: Daily performance feedback|BEHAVIORAL: Gamification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pilot Study Reduced Fluence PDT /Visudyne With Ranibizumab vs Ranibizumab Monotherapy for Exudative Age-related Macular Degeneration (AMD)
Status: WITHDRAWN
Conditions: Macular Edema
Interventions: DRUG: Ranibizumab|DRUG: Ranibizumab monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of AZD6738 and Acalabrutinib in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Ceralasertib|DRUG: Acalabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiorespiratory Performance and Pulmonary Microbiome in Patients After Repair of Esophageal Atresia
Status: UNKNOWN
Conditions: Esophageal Atresia
Interventions: DIAGNOSTIC_TEST: Initial Spirometry|DIAGNOSTIC_TEST: Final Spirometry|DIAGNOSTIC_TEST: Pulmonary microbiome (16S rDNA profiling)|DIAGNOSTIC_TEST: Maximum oxygen uptake|DIAGNOSTIC_TEST: Maximum performance|DIAGNOSTIC_TEST: weight|OTHER: age
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Assess the Safety and Efficacy of ISIS 301012 (Mipomersen) in Homozygous Familial Hypercholesterolemia
Status: COMPLETED
Conditions: Lipid Metabolism, Inborn Errors|Hypercholesterolemia, Autosomal Dominant|Hyperlipidemias|Metabolic Diseases|Hyperlipoproteinemia Type II|Metabolism, Inborn Errors|Genetic Diseases, Inborn|Infant, Newborn, Diseases|Metabolic Disorder|Congenital Abnormalities|Hypercholesterolemia|Hyperlipoproteinemias|Dyslipidemias|Lipid Metabolism Disorders
Interventions: DRUG: mipomersen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Symbicort in Airway Predominant Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Budesonide|DRUG: budesonide/formoterol|DRUG: Ipratropium/albuterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serratus Plane Block Versus Serratus Plane Block Plus Parasternal Block Combination for Breast Surgery
Status: COMPLETED
Conditions: Analgesia|Cancer, Breast
Interventions: OTHER: group serratus plan block|OTHER: group serratus and parasternal plan block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Of Doxycycline & Versus Rifampin In Treatment Of Rhinoscleroma
Status: UNKNOWN
Conditions: Rhinoscleroma
Interventions: DRUG: Doxycycline|DRUG: Ciprofloxacin|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Nutritional Education Strategy and Physical Exercise on the Gut Microbiota in Type 2 Diabetics
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Cardiovascular Diseases|Fat Burn|Metabolism Disorder
Interventions: OTHER: The Moderate-Intensity Continuous Training (MICT)|OTHER: The High-Intensity Interval Training (HIIT)|OTHER: Behavioral: Nutritional education program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Case Series Evaluating Surgimend Mp® In Patients Undergoing Complex Abdominal Hernia Repair
Status: COMPLETED
Conditions: Hernia, Ventral
Interventions: DEVICE: SurgiMend® MP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Trial of Open Versus Laparoscopic Radical Cystectomy at a Laparoscopic Naive Center
Status: COMPLETED
Conditions: Bladder Cancer|Laparoscopy
Interventions: PROCEDURE: Open radical cystectomy|PROCEDURE: Laparoscopic-assisted radical cystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: We Can Prevent Diabetes: A Behavioral Intervention to Reduce Diabetes Risk in African Americans
Status: COMPLETED
Conditions: Prediabetes
Interventions: BEHAVIORAL: Mindfulness-based diabetes prevention education group|BEHAVIORAL: Conventional diabetes prevention education group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Testing the Implementation of Movement-to-Music in a Community Fitness Center and Blended Onsite and Teleexercise Class
Status: WITHDRAWN
Conditions: Exercise|Disability Physical
Interventions: OTHER: Y-M2M©|OTHER: B-M2M©
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Feasibility Study of Peritoneal Ultrafiltration With a Wearable Device, CLS UF, That Adds a Glucose-salt Solution to the Intraperitoneal Fluid in the Device, in Order to Maintain a Stable Intraperitoneal Osmolarity and Thereby Enhance Ultrafiltration.
Status: COMPLETED
Conditions: Ultrafiltration Failure
Interventions: DEVICE: Carry life system, ultrafiltration (CLS UF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Exercise Therapy for People With a Diabetic Foot Ulcer - a Feasibility Study
Status: COMPLETED
Conditions: Diabetic Foot Ulcer|Diabetic Foot|Wound Healing Disorder|Ulcer Foot|Ulcer Healing
Interventions: OTHER: Exercise Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extensively Hydrolyzed Infant Formula in Infants and Children With Cow's Milk Allergy
Status: TERMINATED
Conditions: Cow's Milk Allergy
Interventions: OTHER: Experimental Extensively Hydrolyzed Formula|OTHER: Placebo Extensively Hydrolyzed Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: 7T Magnetic Resonance Spectroscopy and Skeletal Muscle Biopsy Findings in Statin Associated Adverse Muscle Events
Status: TERMINATED
Conditions: Muscle Cramp|Ache|Weakness, Muscle|Statin Adverse Reaction
Interventions: DRUG: Simvastatin 40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase IV, Open Label, 4-period Cross-over Study to Investigate a Drug Interaction Between Lamivudine and Sorbitol Oral Solutions in Healthy Volunteers
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: Lamivudine|DRUG: Sorbitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil
Status: COMPLETED
Conditions: Cognitive Dysfunction|Memory Impairment
Interventions: DRUG: Donepezil 5 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Examining the Ease of Intubation Using the Parker Flex-Tip® or a Standard Endotracheal Tube
Status: COMPLETED
Conditions: Larynx
Interventions: DEVICE: Mallinckrodt (ETT)|DEVICE: Parker Flex-Tip (ETT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Efficacy of Oral Rinses for Inactivation of COVID-19 (MOR2)
Status: RECRUITING
Conditions: COVID-19|Coronavirus Infection|SARS CoV 2 Infection
Interventions: OTHER: Placebo Comparator: Sterile Water|OTHER: 27% Ethanol plus essential oils|OTHER: 0.075% Cetylpyridinium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Health Benefits of Expressive Writing: Study One
Status: COMPLETED
Conditions: Breast Cancer|Breast Neoplasm
Interventions: BEHAVIORAL: Self-Regulation Condition|BEHAVIORAL: Emotional Disclosure Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of 0.01% Atropine Sulfate Solution in Controlling of Myopia Progression in Children
Status: UNKNOWN
Conditions: Myopia
Interventions: COMBINATION_PRODUCT: 0.01% Atropine sulfate solution in "Comfort Drops" ("AVIZOR S.A.", Spain)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TRAC and Power3 Genes Knock-out Allogeneic CD19-targeting CAR-T Cell Therapy in r/r B-NHL
Status: RECRUITING
Conditions: Non Hodgkin's Lymphoma
Interventions: BIOLOGICAL: TRAC and Power3 Genes Knock-out Allogeneic CD19-targeting CAR-T cell (ATHENA CAR-T)|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Oral Ethanol and Vaped Ethanol on the Evaluation of Impairment
Status: COMPLETED
Conditions: Electronic Cigarette Use
Interventions: OTHER: Beverage with ethanol and E-cigarette liquid with ethanol|OTHER: Beverage with ethanol and E-cigarette liquid without ethanol|OTHER: Beverage without ethanol and E-cigarette liquid with ethanol|OTHER: Beverage without ethanol and E-cigarette liquid without ethanol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Coronary IVUS Study to Compare Torcetrapib/Atorvastatin to Atorvastatin Alone in Subjects With Coronary Heart Disease
Status: COMPLETED
Conditions: Coronary Disease|Coronary Arteriosclerosis|Hyperlipidemia
Interventions: DRUG: torcetrapib/atorvastatin|DRUG: atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Autologous Bone Marrow-derived Stem Cells Therapy for Patients With Acute Ischemic Stroke
Status: COMPLETED
Conditions: Acute Stroke
Interventions: BIOLOGICAL: Autologous bone marrow stem cell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serial Lung Function Measurements in Healthy and Mild Asthmatic Adults After Oral Inhalation of Ethanolic Solutions Containing Two Concentrations of the Excipient Butylated Hydroxytoluene (BHT) Administered With the Respimat® B (RMT-B)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: BHT 0.1%|DRUG: BHT 0.5%|DRUG: Placebo for RMT-B|DRUG: Placebo for HFA-MDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Use of the ActiSight™ Needle Guidance System in Patients Undergoing CT-Guided With Lesions Smaller Than 15 mm
Status: COMPLETED
Conditions: Cancer
Interventions: DEVICE: ActiSight™ Needle Guidance System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Evaluation Study of BVAC-B in Patients With HER2/Neu(Human Epithelial Growth Factor Receptor 2) Positive Gastric Cancer After Failure to Standard Care
Status: COMPLETED
Conditions: Stomach Neoplasms
Interventions: BIOLOGICAL: BVAC-B
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Pericapsular Nerve Group Block (PENG) and Morphine Infusion
Status: COMPLETED
Conditions: Analgesia|Femur Fracture
Interventions: PROCEDURE: Pericapsular nerve group block|DRUG: Morphine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intravenous Sodium Bicarbonate Verifies Intravenous Position of Catheters in Spontaneously Breathing Adult Volunteers
Status: UNKNOWN
Conditions: Infiltration|Extravasation
Interventions: DRUG: sodium bicarbonate 4.2%|DRUG: diluted sodium bicarbonate 2.1%|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Investigation of Cannabinoid Receptor Agonist Dronabinol in Patients With Functional Chest Pain
Status: WITHDRAWN
Conditions: Esophageal Diseases
Interventions: DRUG: Dronabinol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Zoledronate for Osteopenia in Pediatric Crohn's
Status: COMPLETED
Conditions: Crohn's Disease|Osteopenia|Osteoporosis
Interventions: DRUG: zoledronic acid|OTHER: IV saline infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Weight Loss Management on Cognitive Function in Elderly Women With Obesity
Status: RECRUITING
Conditions: Obesity|Cognitive Change
Interventions: DIETARY_SUPPLEMENT: "PanTrek"|BEHAVIORAL: Physical Trainings|OTHER: Placebo|BEHAVIORAL: Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effects of Automated Adjustment of FiO2 on Cerebral and Arterial Oxygenation in Preterm Infants
Status: COMPLETED
Conditions: Preterm Infant|RDS
Interventions: DEVICE: Automated FiO2 Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Intestinal Permeability in Cirrhotic Patients Before and After Treatment With Non-selective Beta Blocker (Propranolol)
Status: UNKNOWN
Conditions: Liver Cirrhoses
Interventions: DRUG: Propanolol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HAIC Combined With Sintilimab and Bevacizumab Biosimilar for Unresectable HCC
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: HAIC|DRUG: Sintilimab|DRUG: Bevacizumab Biosimilar
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Different Concentrations of Pressurized-heparin Flushing Fluid on Coagulation and Platelet Function Monitored by the Sonoclot Analyzer
Status: COMPLETED
Conditions: Heparin|Perioperative
Interventions: DRUG: Heparin|DRUG: Heparin|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Tolerability of Nolotil i.v. vs. Placebo i.v. in the Prevention of Postoperative Pain in Children Undergoing Minor Surgery
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Magnesium metamizol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: OPG-RANKL Levels Around Short Implants
Status: COMPLETED
Conditions: Implant-abutment Connection|Microleakage|Short Implant
Interventions: OTHER: Peri-implanter sulcus fluid sampling|OTHER: Probing depth|OTHER: Crestal bone loss|OTHER: Presence of bleeding on probing|OTHER: Plaque index levels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Brain Stimulation and Aphasia Treatment
Status: COMPLETED
Conditions: Aphasia
Interventions: DEVICE: Activa Dose II Real tDCS|DEVICE: Activa Dose II Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Guided Bone Regeneration With Customized Titanium Meshes
Status: UNKNOWN
Conditions: Bone Resorption
Interventions: PROCEDURE: Customized CAD-CAM Titanium Mesh (Y-xoss CBR® by Reoss -Filderstadt - Germany) for Guided Bone Regeneration of atrophic alveolar ridges
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasonography Biofeedback for Diaphragm Training in Athletes With Non-specific Lumbo-pelvic Pain
Status: COMPLETED
Conditions: Ultrasonography|Low Back Pain
Interventions: OTHER: Diaphragm ultrasonography reeducation plus inspiratory training|OTHER: Isolated inspiratory training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of Brentuximab Vedotin in Participants With HIV
Status: WITHDRAWN
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: brentuximab vedotin|DRUG: Placebo|DRUG: ART
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Chimney EndoVascular Aneurysm Sealing Of New Expanded Indication
Status: ACTIVE_NOT_RECRUITING
Conditions: 1 Paravisceral Abdominal Aortic Aneurysm|2 Juxtarenal Abdominal Aortic Aneurysm|3 Pararenal Abdominal Aortic Aneurysm|4 Complex Abdominal Aortic Aneurysms
Interventions: DEVICE: Chimney Endovascular Aortic Sealing (ChEVAS) System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Gene Modified Autologous Hematopoietic Stem Cells to Treat Transfusion-dependent β-thalassemia
Status: RECRUITING
Conditions: β-thalassemia Major
Interventions: GENETIC: BD211
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chagas Cardiomyopathy Bisoprolol Intervention Study: Charity
Status: COMPLETED
Conditions: Chagas Cardiomyopathy|Chronic Heart Failure
Interventions: DRUG: Bisoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Impingement Free Range of Motion With CT Scan After Manual and Robotic Total Hip Replacement
Status: RECRUITING
Conditions: Hip Osteoarthritis|Post-traumatic Osteoarthritis|Inflammatory Arthritis|Congenital Hip Problems|Avascular Necrosis of Hip
Interventions: PROCEDURE: Manual Total Hip Replacement|PROCEDURE: Robot-Assisted Total Hip Replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Women With Epilepsy: a Pilot Study of PK and PD Anti-epileptic Drug Effects in Levonorgestrel Intrauterine System Users
Status: COMPLETED
Conditions: Epilepsy|Contraception
Interventions: DRUG: levonorgestrel IUS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Study of Daratumumab-Based Therapies in Participants With Amyloid Light Chain (AL) Amyloidosis
Status: RECRUITING
Conditions: Amyloidosis
Interventions: DRUG: Daratumumab|DRUG: Cyclophosphamide|DRUG: Bortezomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of "Armored" CAR T Cells Targeting CD19 For Patients With Relapsed CD19+ Hematologic Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia (CLL)|Relapsed|Refractory
Interventions: BIOLOGICAL: EGFRt/19-28z/4-1BBL CAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Escalation, Single Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GB-6002 Local Infiltration in Healthy Male Adults
Status: RECRUITING
Conditions: Pain, Postoperative
Interventions: DRUG: GB-6002|DRUG: Placebo|DRUG: Naropin injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Anesthesia During Neurophysiologic Monitoring in Scoliosis Patients
Status: COMPLETED
Conditions: Idiopathic Scoliosis
Interventions: DRUG: propofol|DRUG: Desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Microscopic Fluorescence-guided Vestibular Schwannoma Resection Using Fluorescein Sodium and YELLOW 560
Status: COMPLETED
Conditions: Vestibular Schwannoma
Interventions: DRUG: Fluorescein Sodium|DEVICE: YELLOW560 filter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: AAV2/8-LSPhGAA (ACTUS-101) in Late-Onset Pompe Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Pompe Disease
Interventions: BIOLOGICAL: ACTUS-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Switch to Dolutegravir/Lamivudine (DTG/3TC) From Current Suppressive Antiretroviral Therapy in People Living With HIV (PLWH) Receiving Opioid Agonist Therapy (OAT)
Status: NOT_YET_RECRUITING
Conditions: HIV-1-infection|Opioid Use Disorder
Interventions: DRUG: DOVATO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Symptoms in Symptomatic Contact Lens Wearers Following Application of Intranasal Tear Neurostimulator Versus Control
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DEVICE: TrueTear|DEVICE: TrueTear Sham Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Weight Loss on Gastroesophageal Reflux Disease in Overweight and Obese Subjects: a Prospective Study
Status: TERMINATED
Conditions: GERD|Obesity
Interventions: BEHAVIORAL: Self support, group sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antipsychotic Effects of Sorghum Bicolor (JOBELYN) in the Treatment of Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia and Disorders With Psychotic Features
Interventions: DIETARY_SUPPLEMENT: Jobelyn|DRUG: Haloperidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ketamine Versus Magnesium Sulfate in the Time and Awakening Quality of General Anesthesia.
Status: RECRUITING
Conditions: Awakening, Post-Anesthesia Delayed
Interventions: OTHER: General anesthesia|DRUG: Ketamine plus general anesthesia|DRUG: Magnesium sulfate plus general anesthesia|DRUG: ketamine plus magnesium sulfate plus general anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Valsartan and Amlodipine in Patients With Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Valsartan + amlodipine 40/2.5 mg|DRUG: Valsartan + amlodipine 40/5 mg|DRUG: Valsartan + amlodipine 80/2.5 mg|DRUG: Valsartan + amlodipine 80/5 mg|DRUG: Valsartan 40 mg|DRUG: Valsartan 80 mg|DRUG: Amlodipine 2.5 mg|DRUG: Amlodipine 5 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Molecular Diagnostics of Bacterial Infections and Antibiotic Resistance in Blood Samples and Rectal Swabs Using Advanced NGS Sequencing Methods
Status: RECRUITING
Conditions: Resistance Bacterial
Interventions: DIAGNOSTIC_TEST: NGS Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessment of a New Apexification Method for Patients Presenting a Non Vital Immature Tooth
Status: COMPLETED
Conditions: Dental Pulp Necrosis
Interventions: DRUG: Mineral Trioxide Aggregate|DRUG: Calcium hydroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Humidified Ventilation on Arterial Oxygenation and Respiratory Mechanics During One Lung Ventilation
Status: COMPLETED
Conditions: Lung Cancer
Interventions: PROCEDURE: Vaporizing humidifier
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Efficacy of Fascia Lata Allograft and Platelet Rich Fibrin on the Periodontal Phenotype Around Dental Implant
Status: NOT_YET_RECRUITING
Conditions: Allograft
Interventions: DRUG: Fascia lata membrane|DRUG: Platlet Rich fibrin membrane|DRUG: subepithelial connective tissue graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers in Tissue Samples From Patients With Stage I or Stage III Endometrial Cancer
Status: UNKNOWN
Conditions: Endometrial Cancer
Interventions: GENETIC: RNA analysis|GENETIC: microarray analysis|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases
Status: TERMINATED
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Astrocytoma|Breast Carcinoma Metastatic in the Brain|Glioma|Invasive Breast Carcinoma|Oligodendroglioma|Prognostic Stage IV Breast Cancer AJCC v8|Recurrent Glioma
Interventions: OTHER: Best Practice|DRUG: Ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sunitinib in Treating Patients With Recurrent Malignant Gliomas
Status: COMPLETED
Conditions: Adult Anaplastic Astrocytoma|Adult Diffuse Astrocytoma|Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Adult Mixed Glioma|Adult Oligodendroglioma|Adult Pineal Gland Astrocytoma
Interventions: DRUG: sunitinib malate|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of CPAP Withdrawal on Cerebral Vascular Reactivity and Brain Oxygenation in OSA
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DEVICE: Continuous positive airway pressure device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinical and Cost-effectiveness of Fluoride Varnish Versus Resin Based Sealant
Status: UNKNOWN
Conditions: Cost Effectiveness
Interventions: DEVICE: fluoride varnish (3M Clinpro White Varnish 5% sodium fluoride )|DEVICE: Resin based fissure sealant (3M Clinpro sealant )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Double-dorsal Versus Single-volar Digital Block
Status: COMPLETED
Conditions: Laceration of Skin|Anesthesia, Local|Pain|Nerve Block
Interventions: PROCEDURE: Dorsal digital block|PROCEDURE: Palmar digital block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Clinical Study of Cadonilimab in Treatment-naïve or Relapsed Extensive Small Cell Lung Cancer
Status: RECRUITING
Conditions: Extensive Small Cell Lung Cancer
Interventions: DRUG: Cadonilimab+EC/ET+RT|DRUG: Cadonilimab+vorolanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RDEA3170 and Febuxostat Combination Study in Gout Subjects
Status: COMPLETED
Conditions: Gout
Interventions: DRUG: RDEA3170 15 mg|DRUG: RDEA3170 10 mg|DRUG: RDEA3170 2.5|DRUG: RDEA3170 5 mg|DRUG: Febuxostat 40 mg|DRUG: Febuxostat 80 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Donated After Cardiac Death (DCD) Utilization With Thrombolytic Therapy
Status: COMPLETED
Conditions: Liver Transplantation|Kidney Transplantation
Interventions: DRUG: rTPA Treatment|OTHER: No TPA Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessing the Feasibility of an Intervention for Youth and Parents Transitioning to Adult Eating Disorder Services
Status: COMPLETED
Conditions: Eating Disorders|Eating Disorders in Adolescence
Interventions: BEHAVIORAL: Transition Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of the Homeopathic Remedy Kalium Bichromicum (Potassium Dichromate) on Viscosity and Amount of Sputum and Time to Extubation in Mechanically Ventilated ICU Patients.
Status: UNKNOWN
Conditions: Mechanical Ventilation
Interventions: DRUG: Potassium Dichromate (Homeopathy)|DRUG: Placebo homeopathic remedy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Bupivacaine and Bupivacaine With Dexmedetomidine in Caudal Block for Post Operative Pain Control
Status: COMPLETED
Conditions: Post Operative Pain
Interventions: DRUG: Bupivacaine Hydrochloride 0.25% Injection Solution|DRUG: Bupivacaine Hydrochloride 0.25% Injection plus Dexmedetomidine 1 microgram/kg body weight
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Talazoparib and Low-Dose Temozolomide in Treating Participants With Relapsed or Refractory Extensive-Stage Small Cell Lung Cancer
Status: RECRUITING
Conditions: Recurrent Extensive Stage Small Cell Lung Carcinoma|Refractory Extensive Stage Small Cell Lung Carcinoma
Interventions: DRUG: Talazoparib|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect Of A Novel Melatonin Supplement On Sleep Quality
Status: ACTIVE_NOT_RECRUITING
Conditions: Sleep
Interventions: DIETARY_SUPPLEMENT: Melatonin|DIETARY_SUPPLEMENT: Placebo supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Evaluating A Novel Ibuprofen Formulation In Episodic Tension-Type Headache
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Novel Ibuprofen|DRUG: Standard Ibuprofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Tow Mechanics for Total-maxillary-arch-distalization
Status: COMPLETED
Conditions: Malocclusion|Class II Division 1 Malocclusion
Interventions: OTHER: One-jaw mechanic total maxillary arch distalization|OTHER: Two-jaw mechanic total maxillary arch distalization|OTHER: en-mass retraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DAOIB for the Treatment of Cognitive Function and Behavioral and Psychological Symptoms of Dementia
Status: COMPLETED
Conditions: Behavioral and Psychological Symptoms in Alzheimer's Disease|Behavioral and Psychological Symptoms in Vascular Dementia
Interventions: DRUG: DAOIB|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Reduction of Ear Pain in Adults With Acute Otitis Media and Reduction of Ear Pain in Adults With Acute Otitis Media
Status: COMPLETED
Conditions: Acute Otitis Media
Interventions: COMBINATION_PRODUCT: Drug: OP0201 20mg|COMBINATION_PRODUCT: Drug: Placebo 0mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of TDM-105795 Following Topical Administration in Male Subjects With Androgenetic Alopecia
Status: COMPLETED
Conditions: Alopecia, Androgenetic
Interventions: DRUG: TDM-105795, 0.0025%|DRUG: TDM-105795, 0.02%|DRUG: TDM-105795 topical vehicle solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of MEHD7945A Versus Cetuximab in Patients With Recurrent/Metastatic Squamous Cell Carcinoma of The Head And Neck
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: MEHD7945A|DRUG: cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maintenance of Remission With Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis.
Status: ACTIVE_NOT_RECRUITING
Conditions: Eosinophilic Granulomatosis With Polyangiitis
Interventions: DRUG: Rituximab|DRUG: Azathioprine|DRUG: Placebo-rituximab|DRUG: Placebo-azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Everolimus on Renal Function in Heart Transplant Recipients With Established Chronic Renal Failure
Status: COMPLETED
Conditions: Cardiac Transplantation|Chronic Renal Insufficiency
Interventions: DRUG: everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Dexmedetomidine Added to Modified Pectoral's Block
Status: UNKNOWN
Conditions: Breast Cancer Female
Interventions: DRUG: Dexmedetomidine Injection [Precedex]|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Randomized Trial Comparing Laparoscopic Roux-en-y Gastric Bypass to Micro-laparoscopic Roux-en-y Gastric Bypass
Status: COMPLETED
Conditions: Obesity
Interventions: PROCEDURE: Microlaparoscopic gastric bypass|PROCEDURE: Laparoscopic Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Endpoint Study of Nepafenac 0.3% Opthalmic Suspension
Status: COMPLETED
Conditions: Cataract
Interventions: DRUG: Nepafenac 0.3% Oph Susp|DRUG: Placebos|DRUG: Nepafenac 0.3% Oph Susp (reference)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Dark Chocolate and Music in Dysmenorrhea
Status: COMPLETED
Conditions: Pain|Primary Dysmenorrhea|Menstrual Pain
Interventions: BEHAVIORAL: music|DIETARY_SUPPLEMENT: Chocolate group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical and Procedural Outcomes of Ostial Left Anterior Descending Artery Intervention With or Without Crossover to Left-main
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Percutaneous coronary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SpO2 Measurement Depending on Different Pulse Oximeter Averaging Time Settings
Status: COMPLETED
Conditions: Movement Artifacts During SpO2 Measurements|Reduced Perfusion During SpO2 Measurements
Interventions: OTHER: Movement artifact - knocking|OTHER: Movement artifact - tremor|OTHER: Artifact - ambient light|OTHER: Artifact - low perfusion|OTHER: SpO2 measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study to Investigate Safety With Risankizumab in Psoriatic Arthritis Subjects Who Have Completed Week 24 Visit of Study M16-002 (NCT02719171)
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: BIOLOGICAL: risankizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Descriptive Analysis of Serum Immunological Markers During an Euploid Frozen Embryo Transfer in a Natural Cycle.
Status: RECRUITING
Conditions: Infertility, Female
Interventions: DRUG: Endometrin 100Mg Vaginal Insert|DRUG: Estradiol Valerate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Study: Repetitive Transcranial Magnetic Stimulation (rTMS) for Treating Movement Disorders in Patients With Intracranial Hemorrhage (ICH).
Status: RECRUITING
Conditions: Intracerebral Hemorrhage
Interventions: DEVICE: rTMS with Magstim Rapid 2 magnetic stimulation device|DEVICE: sham control with Magstim Rapid 2 magnetic stimulation device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability Of Palbociclib (PD-0332991) Under Fed And Fasted Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: palbociclib isethionate (phase 1 and 2 studies)|DRUG: palbociclib isethionate (phase 1 and 2 studies)|DRUG: palbociclib commercial free base capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Investigational Drug Study to Treat Respiratory Symptoms Associated With Respiratory Syncytial Virus (RSV) Bronchiolitis (0476-272)
Status: COMPLETED
Conditions: Bronchiolitis
Interventions: DRUG: montelukast sodium|DRUG: Comparator: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Endoscopic and Laparoscopic Resection for Small Gastric Gastrointestinal Stromal Tumor
Status: UNKNOWN
Conditions: Therapeutic Value of Endoscopic and Laparoscopic Resection for Small Gastric Gastrointestinal Stromal Tumor
Interventions: PROCEDURE: endoscopic management, surgery and follow up
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CHIPs-VTE Study in Hospitalized Patients With Lung Cancer
Status: UNKNOWN
Conditions: Venous Thromboembolic Disease|Pulmonary Embolism|Deep Venous Thrombosis
Interventions: OTHER: Bleeding-risk based prophylaxis strategy during hospitalization and extended pharmacological treatment after discharge|OTHER: Routine VTE prophylaxis in hospital
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Neurocognitive Effects of FMT in MDD Patients With and Without IBS
Status: RECRUITING
Conditions: Major Depressive Disorder|Irritable Bowel Syndrome
Interventions: BIOLOGICAL: Fecal Microbiota Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Fit-One: A Trial Evaluating the Effect of One Drop and Fitbit on Diabetes and Pre-diabetes Outcomes
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Diabetes Mellitus, Type 1|PreDiabetes
Interventions: BEHAVIORAL: One Drop | Experts On Track|BEHAVIORAL: One Drop | Experts On Call|BEHAVIORAL: One Drop | Experts Revive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Letters in Addition to Emailed Audit and Feedback in Refining Asthma Treatment in Primary Care
Status: ACTIVE_NOT_RECRUITING
Conditions: Asthma
Interventions: OTHER: Provision of audit and feedback via email and paper|OTHER: Provision of audit and feedback via paper only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Efficacy and Safety of Curalin as Add-On Therapy in Adults With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Curalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Blood Sugar Levels and Endothelial Function of PEAK ATP® With GlycoCarn®, PEAK ATP® and GlycoCarn® Supplements
Status: COMPLETED
Conditions: Blood Sugar|Endothelial Function
Interventions: DIETARY_SUPPLEMENT: PEAK ATP® with GlycoCarn®|DIETARY_SUPPLEMENT: PEAK ATP®|DIETARY_SUPPLEMENT: GlycoCarn®|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Drug Concentration, Immunogenicity, and Efficacy Study in Patients With Rheumatoid Arthritis Currently Treated With Etanercept, Adalimumab, or Infliximab
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: OTHER: no intervention|OTHER: no intervention|OTHER: no intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Trial to Evaluate the Safety and Tolerability of Dexlansoprazole Injection in Healthy Chinese Adults（Part 2）
Status: UNKNOWN
Conditions: Effect of Drugs|Safety Issues
Interventions: DRUG: Dexlansoprazole Injection|DRUG: Lansoprazole Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Exercise on Physiological Adaptation Capacity and Chronic Pain in Individuals With Cardiovascular Risk
Status: COMPLETED
Conditions: Cardiometabolic Risk Factors
Interventions: BEHAVIORAL: High-Intensity Interval Training|BEHAVIORAL: Resistance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post Market Clinical Follow-Up Study for EVOLUTION® NitrX™ Keeled Tibia and EVOLUTION® NitrX™ CS/CR Femur With Cruciate Sacrificing Insert
Status: ENROLLING_BY_INVITATION
Conditions: Joint Diseases|Osteoarthritis|Arthritis Knee|Avascular Necrosis
Interventions: DEVICE: EVOLUTION® NitrX™
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p