pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Trial Comparing Pain During Local Tumesent Injection In Fingers Using Different Syringe-Needle Combinations
Status: UNKNOWN
Conditions: Anesthesia, Local|Infiltration|Injection Site|Pain
Interventions: PROCEDURE: Injection using 1 cc of NaCl 0.9%|OTHER: Patient Preference Question|OTHER: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation and Evaluation of the Graded Repetitive Arm Supplementary Program (GRASP) for People With Stroke
Status: RECRUITING
Conditions: Stroke
Interventions: OTHER: Rehabilitation exercises|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TANTALUS Therapy in Type 2 Diabetic Patients Intolerant or Inadequately Responsive to GLP-1 Receptor Agonist Therapy
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: DEVICE: TANTALUS System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Rotigotine on Motor Symptoms in Patients With Advanced Parkinson's Disease (PD) With Motor Fluctuations and Symptoms of Gastrointestinal Dysfunction
Status: TERMINATED
Conditions: Advanced Parkinson's Disease
Interventions: DRUG: Rotigotine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pemetrexed Combined With Cisplatin and Radiotherapy for Unresectable Locally Advanced Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: combination chemotherapy (pemetrexed + cisplatin)|RADIATION: thoracic irradiation + pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: FOLFIRI regimen|DRUG: FOLFOX regimen|DRUG: fluorouracil|DRUG: irinotecan hydrochloride|DRUG: leucovorin calcium|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Tazarotene Cream 0.1% to TAZORAC® (Tazarotene) Cream 0.1% and Both to a Placebo Control in the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Tazarotene Cream 0.1%|DRUG: Tazorac®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DS-6157a in Participants With Advanced Gastrointestinal Stromal Tumor (GIST)
Status: TERMINATED
Conditions: Gastrointestinal Stromal Tumors
Interventions: DRUG: DS-6157a
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Neuroprotective Effect of Remote Ischemic Conditioning in Aneurysm Coiling Therapy
Status: UNKNOWN
Conditions: Aneurysm
Interventions: DEVICE: remote ischemic conditioning|DEVICE: sham remote ischemic conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: tDCS and Cognitive Efficiency
Status: UNKNOWN
Conditions: Aging|Mild Cognitive Impairment|Alzheimer Disease
Interventions: DEVICE: Transcranial direct current stimulation (tDCS)|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy and PK/PD of POL7080 in Patients With Exacerbation of Non-cystic Fibrosis Bronchiectasis.
Status: TERMINATED
Conditions: Bronchiectasis|Lower Respiratory Infection
Interventions: DRUG: POL7080
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diet and Hereditary Haemorrhagic Telangiectasia
Status: COMPLETED
Conditions: Hereditary Haemorrhagic Telangiectasia (HHT)
Interventions: OTHER: Questionnaire on dietary history|OTHER: Questionnaire on nosebleed severity|OTHER: One week food diary generated by weighing foods|PROCEDURE: Blood tests for full blood count, albumin, and indices of nutritional status
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Exosome Proteomics to Detect EPO
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: Erythropoietin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Challenge Test for Acetylsalicylic Acid Hypersensitivity
Status: UNKNOWN
Conditions: Asthma Aspirin-sensitive|ASA Intolerant Asthma|Asthma, Aspirin-Induced|Asthma, Nasal Polyps, and Aspirin Intolerance
Interventions: DRUG: Acetylsalicylate|DRUG: Isotonic NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Olfactory and Neurosensory Rehabilitation in COVID-19-related Olfactory Dysfunction
Status: UNKNOWN
Conditions: Coronavirus Disease 2019
Interventions: DRUG: Vitamin A|DEVICE: Electronic portable aromatic rehabilitation (EPAR) diffuser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study on the Effectiveness of a Flexible Hydroxyapatite-Based Composite for Jaw Bone Regeneration
Status: NOT_YET_RECRUITING
Conditions: Bone Atrophy|Edentulism|Bone Regeneration
Interventions: DEVICE: Placement of resorbable HAp-based composite
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dysferlinopathy Protein in Peripheral Blood Monocytes.
Status: COMPLETED
Conditions: Muscular Dystrophies|Limb-Girdle Muscular Dystrophy Type 2B|Miyoshi Myopathy|Distal Myopathy With Anterior Tibial Onset
Interventions: DIAGNOSTIC_TEST: Protein analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Pemetrexed and Folic Acid Given Before Surgery (Neoadjuvant Treatment) to Patients With Rectal Cancer.
Status: COMPLETED
Conditions: Rectal Neoplasms
Interventions: DRUG: pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Boron Neutron Capture Therapy Following Surgery in Treating Patients With Glioblastoma Multiforme Removed During Surgery
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: sodium borocaptate|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ivermectin in Outpatients With Non-severe COVID-19
Status: UNKNOWN
Conditions: Covid19|Coronavirus Infection
Interventions: DRUG: Ivermectin Tablets|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment FOr Corticosteroid Dependent UveitiS
Status: NOT_YET_RECRUITING
Conditions: Non Infectious Uveitis
Interventions: DRUG: Adalimumab|DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pemetrexed and Carboplatin Compared With Etoposide Carboplatin to Treat Extensive-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: pemetrexed|DRUG: etoposide|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Antipyretic Treatment in Children Receiving Booster Dose of Pneumococcal Conjugate Vaccine GSK1024850A
Status: COMPLETED
Conditions: Infections, Streptococcal
Interventions: BIOLOGICAL: Pneumococcal conjugate vaccine GSK1024850A.|BIOLOGICAL: Infanrix hexa.|BIOLOGICAL: Meningococcal vaccine GSK134612.|DRUG: Paracetamol.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Does Oxytocin Modulate Rewarding Effects in Women and Fluctuating Across the Menstrual Cycle
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxytocin|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Large Randomized Trial of Vitamin D, Omega-3 Fatty Acids and Cognitive Decline
Status: COMPLETED
Conditions: Cognitive Decline
Interventions: DIETARY_SUPPLEMENT: vitamin D3|DRUG: omega-3 fatty acids (fish oil)|DIETARY_SUPPLEMENT: Vitamin D3 placebo|DIETARY_SUPPLEMENT: Fish oil placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ultrasound Comparison of the Surface of the Subclavian and the Axillary Vein Versus the Surface of the Subclavian Vein
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: PROCEDURE: Ultrasound measures
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment Of Bronchiolitis With Heated Humidified High Flow Nasal Cannula - Prospective And Retrospective Research
Status: UNKNOWN
Conditions: Bronchiolitis
Interventions: DEVICE: HeatedHumidifiedHighFlowNasalCannula
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dasatinib in Relapsed or Refractory Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Dasatinib|DRUG: Dasatinib Maximum Tolerated Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0910 Epratuzumab, Cytarabine, and Clofarabine in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: epratuzumab|DRUG: clofarabine|DRUG: cytarabine|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The University of the Philippines Hydroxychloroquine PEP Against COVID-19 Trial
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: Hydroxychloroquine plus standard preventive measures|DRUG: Placebo plus standard preventive measures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Credibility of Ultrasound Detection of Female Genital Prolapse Mesh
Status: COMPLETED
Conditions: Ultrasound Therapy; Complications
Interventions: DIAGNOSTIC_TEST: Perineal/introital ultrasound examination, two different examiners. The examiners are blinded to each other and to the previous prolapse surgery.|DIAGNOSTIC_TEST: Perineal/introital ultrasound examination, two different examiners. The examiners is now being informed of the previous prolapse surgery.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of FIH of STX-241 in Locally Advanced or Metastatic NSCLC Resistant to EGFR TKIs
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: DRUG: STX-241
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient Reported Outcome After Stemmed Versus Stemless Total Shoulder Arthroplasty for Glenohumeral Osteoarthritis.
Status: ACTIVE_NOT_RECRUITING
Conditions: Shoulder Pain|Shoulder Osteoarthritis|Shoulder Arthritis
Interventions: DEVICE: Stemmed shoulder arthroplasty, Biomet Comprehensive® Total Shoulder System.|DEVICE: Stemless shoulder arthroplasty, Biomet Comprehensive® Nano Shoulder System.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluate Safety & Immunogenicity of a Pandemic Influenza Vaccine (GSK1562902A) in Adults Over 60 Years of Age
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Pandemic influenza vaccine (GSK1562902A) (adjuvanted or not)|BIOLOGICAL: Fluarix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants
Status: COMPLETED
Conditions: Hand, Foot, and Mouth Disease|Enterovirus Infections
Interventions: BIOLOGICAL: 160U /0.5ml|BIOLOGICAL: 320U /0.5ml|BIOLOGICAL: 640U /0.5ml|BIOLOGICAL: 0/0.5ml placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study on Immunogenicity and Safety of a Meningococcal ACYW Conjugate Vaccine in Healthy Infants and Toddlers
Status: RECRUITING
Conditions: Meningococcal Immunisation|Healthy Volunteers
Interventions: BIOLOGICAL: MenACYW conjugate vaccine|BIOLOGICAL: MenACYW conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 3 Study to Evaluate the Efficacy and Safety of ORMD-0801 in Subjects With Type 2 Diabetes Mellitus
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: ORMD-0801
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Testing a Scalable Model of Care to Improve Patients Access to Mental Health Services After Traumatic Injury
Status: RECRUITING
Conditions: Posttraumatic Stress Disorder|Depression
Interventions: BEHAVIORAL: Trauma Resilience and Recovery Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Silver Diamine Fluoride and Sodium Fluoride Varnish to Prevent and Arrest Root Caries in Older Adults
Status: SUSPENDED
Conditions: Root Caries
Interventions: DEVICE: Silver Diamine Fluoride|DEVICE: Soduim Fluoride Varnish|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PD-1 Inhibitor Therapy Versus Radiotherapy in pCR Patients With Locally Advanced HNSCC After Neoadjuvant Immunochemotherapy
Status: RECRUITING
Conditions: HNSCC|Radiotherapy|PD-1
Interventions: DRUG: PD-1inhibitor|RADIATION: concurrent chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PurIST Classification-Guided Adaptive Neoadjuvant Chemotherapy by RNA Expression Profiling of EUS Aspiration Samples
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: mFOLFIRINOX Treatment Regimen|DRUG: Gemcitabine/Nab-paclitaxel Treatment Regimen|RADIATION: Chemoradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Randomized Trial of mFOLFIRINOX +/- Ramucirumab in Advanced Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: mFOLFIRINOX|DRUG: Ramucirumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Dalpiciclib Plus Toremifene in the Treatment of Advanced First-line HR Positive and HER2 Negative Breast Cancer: a Multicenter, Single Arm, Exploratory Phase II Clinical Study
Status: NOT_YET_RECRUITING
Conditions: CANCER|BRAEST CANCER|Late Frontline
Interventions: DRUG: Dalpiciclib，Toremifen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Exposure Versus In Vivo Exposure for Fear of Heights
Status: COMPLETED
Conditions: Fear of Heights|Acrophobia|Specific Phobia|Anxiety Disorder
Interventions: BEHAVIORAL: Exposure Therapy (In Vivo)|BEHAVIORAL: Exposure Therapy (Virtual Reality)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Injection of REGN475/SAR164877 in Treatment of Vertebral Fracture Pain
Status: TERMINATED
Conditions: Back Pain
Interventions: DRUG: REGN475/SAR164877|DRUG: Placebo (for REGN475/SAR164877)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Chemotherapy in Combination With Camrelizumab for Stage III Gastric Cancer (FOCUS-02)
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric Cancer Stage III
Interventions: DRUG: Camrelizumab|DRUG: Oxaliplatin|DRUG: Tegafur gimeracil oteracil potassium capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Response to Vascular Injury in Patients With Diabetes Mellitus: An OCT Study of BVS Versus Xience DES
Status: WITHDRAWN
Conditions: Coronary Artery Disease|Diabetes Mellitus
Interventions: DEVICE: Xience Drug Eluting Stent|DEVICE: ABSORB Bioresorbable Vascular Scaffold
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Effect of Tiotropium + Olodaterol Fixed Dose Combination on Exercise Endurance Time During Constant Work Rate Cycle Ergometry Test in COPD
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DEVICE: Respimat inhaler|DRUG: tiotropium+olodaterol (low dose)|DRUG: tiotropium + olodaterol (high dose)|DEVICE: Respimat inhaler|DEVICE: Respimat inhaler|DRUG: placebo to tiotropium+olodaterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A RCT of Ultrasound Guided IUD Insertion
Status: COMPLETED
Conditions: IUD Not Visible
Interventions: PROCEDURE: Transabdominal Ultrasound Guided IUD Insertion|PROCEDURE: Traditional Blind IUD Insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dry Needling Vs Transcutaneous Electrical Nerve Stimulation in Management of Myofascial Pain Dysfunction Syndrome
Status: NOT_YET_RECRUITING
Conditions: Myofascial Pain - Dysfunction Syndrome of TMJ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autogenous vs. Xenogeneic Peri-implant Soft Tissue Grafts Placed in Full vs. Split Thickness Flaps
Status: RECRUITING
Conditions: Thin Gingiva
Interventions: PROCEDURE: Split thickness flap|PROCEDURE: Full thickness flap|PROCEDURE: Autogenous sub epithelial connective tissue graft|PROCEDURE: Volume stable collagen matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Default Bulk Ordering and Text Messaging to Enhance Outreach for Lipid Screening (Missing Lipids)
Status: COMPLETED
Conditions: Atherosclerotic Cardiovascular Disease
Interventions: BEHAVIORAL: Outreach + Bulk ordering|BEHAVIORAL: Outreach + Bulk ordering + Text Based Reminders and Scheduling assistance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Recombinant Human Thrombopoietin(rhTPO) in Pregnancy With Immune Thrombocytopenia
Status: UNKNOWN
Conditions: Immune Thrombocytopenia
Interventions: DRUG: recombinant human thrombopoietin|DRUG: Platelet Concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Nutrient Dense Food on the Skin CarotenoidLevels of School Age Children
Status: COMPLETED
Conditions: Raman Spectroscopy|Children, Only
Interventions: OTHER: Feeding trial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Comparison of Vacuum Assisted Closure and Saline Dressing in Patients With Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot
Interventions: DEVICE: Vacuum Assisted Closure|OTHER: Saline Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupressure for Reducing Anxiety in Patients Undergoing Chemotherapy
Status: RECRUITING
Conditions: Hematopoietic and Lymphatic System Neoplasm|Malignant Solid Neoplasm
Interventions: PROCEDURE: Acupressure Therapy|OTHER: Educational Intervention|OTHER: Electronic Health Record Review|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PET/CT in Evaluating Response to Chemotherapy in Patients With Breast Cancer
Status: TERMINATED
Conditions: HER2-positive Breast Cancer|Recurrent Breast Cancer|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer
Interventions: OTHER: laboratory biomarker analysis|OTHER: pharmacological study|OTHER: questionnaire administration|RADIATION: fluorine F 18-clevudine|PROCEDURE: positron emission tomography/computed tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: AVB-500 (Batiraxcept) in Combination With Paclitaxel in Recurrent High Grade Uterine Cancer
Status: NOT_YET_RECRUITING
Conditions: Recurrent High Grade Uterine Cancer
Interventions: DRUG: Paclitaxel|DRUG: Batiraxcept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block for Postoperative Pain Management
Status: COMPLETED
Conditions: Pain|Post Operative Pain
Interventions: PROCEDURE: Control|PROCEDURE: Erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression
Status: RECRUITING
Conditions: Depression, Anxiety|Fear|Depression|Anxiety and Fear|Anxiety Disorders|Anxious Depression
Interventions: DRUG: Lorazepam|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Systemic Mastocytosis
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Nonneoplastic Condition|Precancerous Condition
Interventions: DRUG: tanespimycin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diet and Microbiome Longitudinal Monitoring With Food Intervention
Status: ACTIVE_NOT_RECRUITING
Conditions: Microbiome, Human|Gastrointestinal Tract
Interventions: OTHER: Food provided from a commercial meal service provider for a week
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 1 Single-Dose Escalation Study of PF-04308515 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: PF-04308515|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Using Topical Sirolimus 2% for Patients With Epidermolysis Bullous Simplex (EBS) Study
Status: UNKNOWN
Conditions: Epidermolysis Bullosa Simplex|Epidermolysis Bullosa Simplex Kobner|Weber-Cockayne Syndrome
Interventions: DRUG: Sirolimus 2%|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Regional or General Anesthesia for Carotid Endarterectomy in Patients With Acute Stage of Ischemic Stroke.
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: PROCEDURE: carotid endarterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Tregs for the Treatment of Acute Respiratory Distress Syndrome (ARDS) Associated With COVID-19 (regARDS)
Status: TERMINATED
Conditions: Acute Respiratory Distress Syndrome Due to Disease Caused by 2019-nCoV
Interventions: BIOLOGICAL: Cryopreserved Ex Vivo Expanded Polyclonal CD4+CD127lo/-CD25+ T Regulatory Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnesium Nebulization Utilization in Management of Pediatric Asthma
Status: COMPLETED
Conditions: Acute Asthma
Interventions: DRUG: Magnesium Sulfate Sandoz|DRUG: Sodium Chloride , USP PPC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Erenumab (AMG 334) in Chronic Migraine Prevention
Status: COMPLETED
Conditions: Treatment for Prevention of Chronic Migraine
Interventions: BIOLOGICAL: Erenumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation: A Personalized Approach
Status: COMPLETED
Conditions: Major Depressive Disorder|Overweight|Inflammation
Interventions: OTHER: Placebo|DRUG: EPA 1 g/day|DRUG: EPA 2 g/day|DRUG: EPA 4 g/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Different Ultrasound Guided Techniques for Saphenous Nerve Block
Status: COMPLETED
Conditions: Efficacy of Ultrasound Guided Nerve Block
Interventions: PROCEDURE: Saphenous nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of GSK1358820 (Botulinum Toxin Type A) in Chinese Subjects With Post-stroke Upper Limb Spasticity
Status: COMPLETED
Conditions: Cerebrovascular Accident
Interventions: DRUG: GSK1358820(Botulinum toxin type A)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Vantictumab (OMP-18R5) in Combination With Nab-Paclitaxel and Gemcitabine in Previously Untreated Stage IV Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer|Stage IV Pancreatic Cancer
Interventions: DRUG: Vantictumab|DRUG: Nab-Paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Randomized Trial on Mycophenolate Mofetil in Risk Penetrating Keratoplasty
Status: COMPLETED
Conditions: Corneal Transplantation
Interventions: DRUG: Mycophenolate Mofetil 2x 1g
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Water-Based Exercise on Lipid Profile and Lipoprotein Lipase of Dyslipidemic Premenopausal Women
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: OTHER: Water Aerobics Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metformin for Prevention Gestational Diabetes in Pregnant Women With Polycystic Ovarian Syndrome
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome|Diabetes, Gestational
Interventions: DRUG: metformin|DRUG: placebo (folic acid )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Motor Network in Essential Tremor: Mechanisms of Therapy
Status: RECRUITING
Conditions: Essential Tremor|Parkinson's Disease
Interventions: PROCEDURE: Deep brain stimulation implantation surgery|DEVICE: Ad-Tech Medical Instrumentation Corp. electrodes/subdural strips|DEVICE: FHC Guideline 4000+ system and/or Medtronic RC+S
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Cognicise and Arch Support Insoles in Older Adults With Mild Cognitive Impairment
Status: UNKNOWN
Conditions: Mild Cognitive Impairment
Interventions: OTHER: cognicise|DEVICE: arch support insoles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Properties of Myocardial Microcirculation in Patients With Different Pathomorphological Substrates, Before and After Recanalization of Coronary Artery CTO
Status: UNKNOWN
Conditions: Chronic Total Occlusion of Coronary Artery
Interventions: PROCEDURE: percutaneous coronary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiency
Status: COMPLETED
Conditions: Alpha-1 Antitrypsin Deficiency|Emphysema|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Aspirin|DRUG: Placebo|OTHER: Withdrawal from alpha1 antitrypsin replacement therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of the Effect of Fasting and Exercise on Uptake of Tc-99m Sestamibi in Breast Tissue
Status: COMPLETED
Conditions: Molecular Imaging
Interventions: DIETARY_SUPPLEMENT: Meal|OTHER: Exercise|RADIATION: Sestamibi|DRUG: Caffeine Tablet|OTHER: External Heating
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Allogeneic Hematopoietic Stem Cell Transplantation for Relapsed or Refractory High-Risk NBL.
Status: WITHDRAWN
Conditions: Neuroblastoma
Interventions: OTHER: anti-thymocyte globulin|DRUG: busulfan|DRUG: cyclosporine|DRUG: fludarabine phosphate|DRUG: mycophenolate mofetil|DRUG: tacrolimus|PROCEDURE: allogeneic hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bicalutamide in Treating Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: bicalutamide|OTHER: diagnostic laboratory biomarker analysis|OTHER: immunohistochemistry staining method
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Healthy Humans.
Status: COMPLETED
Conditions: Healthy Humans
Interventions: BEHAVIORAL: High Sodium Diet|BEHAVIORAL: Low Sodium Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Diagnostic Platform to Perform Centralized and Standardized Rapid Molecular Diagnosis by Next Generation Sequencing (NGS) in Patients Diagnosed With Acute Myeloid Leukemia.
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DIAGNOSTIC_TEST: NGS techniques
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Enzalutamide and Cabazitaxel in Treating Patients With Metastatic, Castration-Resistant Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Castration-Resistant Prostate Carcinoma|Metastatic Prostate Carcinoma|Recurrent Prostate Carcinoma|Stage IV Prostate Cancer AJCC v7
Interventions: DRUG: Cabazitaxel|DRUG: Enzalutamide|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Rosiglitazone on Ischemia-reperfusion-injury Using Annexin A5 Scintigraphy.
Status: COMPLETED
Conditions: Ischemia-Reperfusion Injury|The Metabolic Syndrome
Interventions: DRUG: rosiglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CLN-0046: Treatment of AMD Subjects With OTX-TKI
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: OTX-TKI|DRUG: OTX-TKI|DRUG: OTX-TKI|DRUG: OTX-TKI|DRUG: Anti-VEGF|DRUG: OTX-TKI|DRUG: Anti-VEGF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous 24h Intravenous Infusion of Mithramycin, an Inhibitor of Cancer Stem Cell Signaling, in People With Primary Thoracic Malignancies or Carcinomas, Sarcomas or Germ Cell Neoplasms With Pleuropulmonary Metastases
Status: TERMINATED
Conditions: Esophageal Neoplasms|Lung Neoplasms|Mesothelioma|Thymus Neoplasms|Neoplasms, Germ Cell and Embryonal
Interventions: DRUG: Mithramycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Tolerance and Safety of a New Partly Fermented Anti-regurgitation Infant Formula
Status: COMPLETED
Conditions: Regurgitation, Gastric
Interventions: OTHER: Anti-regurgitation infant formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Long-Term Quitting (Smoking Cessation) Study
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Nicotine Mini-Lozenge for 11 Months|BEHAVIORAL: Preparation Phase Behavioral Reduction Counseling|BEHAVIORAL: Preparation Phase Recycling Counseling|BEHAVIORAL: Preparation Phase Control Treatment|BEHAVIORAL: Cessation Phase Supportive Counseling|BEHAVIORAL: Cessation Phase Skill Training Counseling|BEHAVIORAL: Cessation Phase Brief Information|DRUG: Cessation Phase Nicotine Patch + Nicotine Mini-Lozenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Single Doses of SAR113945 and Efficacy and Safety of a New Formulation Given Into the Knee in Osteoarthritis Patients / Part II
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: SAR113945|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Coring Out Fistulectomy With Closure of Internal Sphincter Opening Versus Lay Open Fistulotomy and Primary Sphincter Repair in Transsphincteric Perianal Fistula
Status: COMPLETED
Conditions: Coring Out|Fistulectomy|Internal Sphincter|Lay Open Fistulotomy|Sphincter Repair|Transsphincteric Perianal Fistula
Interventions: PROCEDURE: Coring out Fistulectomy with Closure of Internal Sphincter Opening|PROCEDURE: Lay Open Fistulotomy and Primary Sphincter Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity, Safety, Tolerability and Ability to Prime for Memory of Meningococcal C Conjugate Vaccine in Healthy Children
Status: COMPLETED
Conditions: Prevention of Meningococcal Infection
Interventions: BIOLOGICAL: Meningococcal C conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Long Term Study to Find Out if Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease
Status: TERMINATED
Conditions: Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease
Interventions: DRUG: macitentan 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Navi-Star Thermo-Cool Catheter For Ablation of Atrial Fibrillation
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: GP ablation + PV isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Computer-assisted Preventive Health Education for Women of Reproductive Age in Urgent Care Settings
Status: COMPLETED
Conditions: Preconception Care
Interventions: BEHAVIORAL: "video doctor," computer module
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Improving Care After Inherited Cancer Testing
Status: RECRUITING
Conditions: Inherited Cancer Syndrome|Prostate Cancer|Colorectal Cancer|Endometrial Cancer|Breast Cancer
Interventions: OTHER: Correlative Studies (Survey)|OTHER: Correlative Studies (Interview)|BEHAVIORAL: GeneSHARE|BEHAVIORAL: LivingLabReport|BEHAVIORAL: Standard-of-care & Adaptive Intervention|OTHER: Access to Education Materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessment of ARVO Web-based Software for Evaluating Attention-Deficit/Hyperactive Disorder (ADHD) Symptoms in Children
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DEVICE: ARVO 2.0 WEB|OTHER: Conners Continuous Performance Test 3rd Edition™ (CPT 3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Do the SPPB and 4-metre Gait Speed Predict Hospital Readmission in Patients Hospitalised for Acute Exacerbation if COPD?
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|Respiratory Tract Diseases|Lung Diseases|Lung Diseases, Obstructive|Bronchitis, Chronic|Pulmonary Emphysema|Disease Progression
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bismuth Quadruple Therapy for Helicobacter Pylori Rescue Therapy of Different Tetracycline Doses and Frequencies.
Status: RECRUITING
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Tetracyclin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Mental Health Problems in People Exposed to a Recent Highly Stressful Event.
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder|Acute Post-Traumatic Stress Disorder|Depressive Symptoms
Interventions: OTHER: Mindfulness|OTHER: Systemic therapy|OTHER: Cognitive behavioral therapy and positive psychology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Intranasal Steroids and the Nasal Ocular Response
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: fluticasone furoate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Therapeutic Dose of tDCS for Functional Upper Limb Recovery in People With Stroke
Status: NOT_YET_RECRUITING
Conditions: Stroke|Neurologic Deficits
Interventions: DEVICE: Transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Atezolizumab Combination Treatments in Participants With HER2-Positive and HER2-Negative Breast Cancer
Status: COMPLETED
Conditions: HER2-Positive Metastatic Breast Cancer|HER2-Negative Metastatic Breast Cancer|Locally Advanced or Early Breast Cancer
Interventions: DRUG: Atezolizumab|DRUG: Carboplatin|DRUG: Docetaxel|DRUG: Pertuzumab|DRUG: Trastuzumab|DRUG: Trastuzumab emtansine|DRUG: Doxorubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hereditary Parkinson s Disease Natural History Protocol
Status: COMPLETED
Conditions: Parkinson Disease 6, Early-Onset|Parkinson Disease (Autosomal Recessive, Early Onset) 7, Human|Parkinson Disease Autosomal Recessive, Early Onset|Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Zinc Supplementation to Reduce Diarrhea Rates in Adults in Western Kenya.
Status: COMPLETED
Conditions: Diarrhea|Malaria
Interventions: DIETARY_SUPPLEMENT: Zinc sulphate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Randomized Controlled Trial Comparing Picosalax and Oral Sodium Phosphate for Colon Cleansing Prior to Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: picosalax plus bisacodyl|DRUG: picosalax|DRUG: sodium phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Early Coma Arousal Therapy on Conscious Level Recovery and Cognition in Traumatic Brain Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury With Loss of Consciousness
Interventions: OTHER: Coma arousal therapy|OTHER: Selected physiotherapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of Lessertia Frutescens in Adults.
Status: COMPLETED
Conditions: Drug Safety
Interventions: DRUG: Lessertia Fructescens|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Investigate the Effect of Dietary Fibre Supplementation on Long-term Glucose Control in Prediabetic Subjects
Status: UNKNOWN
Conditions: Dietary Habits
Interventions: DIETARY_SUPPLEMENT: Soluble Fibre|DIETARY_SUPPLEMENT: Calorie Matched Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Inhalation of Liposomal Amphotericin B to Prevent Invasive Aspergillosis
Status: COMPLETED
Conditions: Aspergillosis
Interventions: DRUG: nebulised liposomal amphotericin B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: First-in-Human Dose Escalation Trial in Subjects With Advanced Malignancies
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: MSC2363318A|DRUG: MSC2363318A plus Trastuzumab|DRUG: MSC2363318A plus Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Human Systemic Absorption of Sunscreen Ingredients
Status: COMPLETED
Conditions: Systemic Exposure to Sunscreen Ingredients
Interventions: DRUG: Part 1: Cream|DRUG: Part 1: Lotion|DRUG: Part 1: Spray 1|DRUG: Part 1: Spray 2|DRUG: Part 2: Lotion|DRUG: Part 2: Aerosol Spray|DRUG: Part 2: Nonaerosol Spray|DRUG: Part 2: Pump Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: IL-6 Inhibition for Modulating Inflammation After Cardiac Arrest
Status: COMPLETED
Conditions: Heart Arrest|Out-Of-Hospital Cardiac Arrest|Systemic Inflammatory Response Syndrome
Interventions: DRUG: Tocilizumab 20 Mg/mL Intravenous Solution|DRUG: isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT