pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Differentiated Thyroid Cancer
Interventions: DRUG: Cabozantinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare MitoQ and Placebo to Treat Non-alcoholic Fatty Liver Disease (NAFLD)
Status: TERMINATED
Conditions: Non-alcoholic Fatty Liver Disease
Interventions: DRUG: Mitoquinone mesylate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FUSCC Refractory TNBC Platform Study (FUTURE2.0)
Status: RECRUITING
Conditions: Triple-negative Breast Cancer
Interventions: DRUG: A1: SHR-A1811|DRUG: A2: SHR-A1811 with Camrelizumab|DRUG: B1: TROP2 ADC|DRUG: B2: TROP2 ADC with Camrelizumab|DRUG: C1: SHR-A1811|DRUG: C2: SHR-A1811 with BP102|DRUG: D1: TROP2 ADC|DRUG: D2: TROP2 ADC with BP102|DRUG: E1: SHR-A1811|DRUG: F1: TROP2 ADC|DRUG: G1: SHR-A1811|DRUG: H1: TROP2 ADC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined THC and CBD Drops for Treatment of Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: THC 5mg/ml and CBS 50mg/ml|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Theta Burst TMS for Treatment of Methamphetamine Use Disorder
Status: RECRUITING
Conditions: Methamphetamine Abuse
Interventions: DEVICE: Transcranial Magnetic Stimulation|DEVICE: Sham Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Programmed Death Ligand (PD-L1) Combined With Chemotherapy for Patients With BTC
Status: ACTIVE_NOT_RECRUITING
Conditions: Biliary Tract Neoplasms
Interventions: DRUG: KN035 plus Gemcitabine & oxaliplatin|DRUG: Gemcitabine & oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: WashIn /WashOut Procedure To Prevent Agitation During Recovery After Inhalational Anesthesia With Sevoflurane
Status: RECRUITING
Conditions: Agitation, Emergence|Postoperative Delirium|Postoperative Cognitive Dysfunction
Interventions: PROCEDURE: WashIn /WashOut
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, and Pharmacokinetics of a Single Oral Dose of SKI-O-703 in Healthy Volunteers
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: SKI-O-703 capsule|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Surgical Treatment for Trapeziometacarpal Osteoarthritis Eaton & Glickel Stage 2-3
Status: UNKNOWN
Conditions: Trapeziometacarpal Osteoarthritis|Thumb Carpometacarpal Osteoarthritis
Interventions: PROCEDURE: Total Joint Arthroplasty|PROCEDURE: Trapeziectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The LATITUDE Study: Long-Acting Therapy to Improve Treatment SUccess in Daily LifE
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections
Interventions: DRUG: Standard of Care (SOC) Oral ART|DRUG: Oral RPV|DRUG: Oral CAB|DRUG: RPV-LA Loading Dose|DRUG: CAB-LA Loading Dose|DRUG: RPV-LA Maintenance Dose|DRUG: CAB-LA Maintenance Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MESH MIGRATION IN TOTAL EXTRAPERITONEAL INGUINAL HERNI REPAIR
Status: NOT_YET_RECRUITING
Conditions: Inguinal Hernia
Interventions: DIAGNOSTIC_TEST: inguinal ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Ketamine for Conscious Sedation in Flexible Bronchoscopy
Status: COMPLETED
Conditions: Conscious Sedation|Patient Satisfaction|Ketamine
Interventions: DRUG: Ketamine|DRUG: Midazolam|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Reciprocal Inhibition Versus Post Facilitation Muscle Energy Technique Along With Conventional Physical Therapy in Patients With Piriformis Syndrome: a Randomized Controlled Trial
Status: RECRUITING
Conditions: Piriformis Syndrome
Interventions: OTHER: Reciprocal Inhibition MET|OTHER: Post-facilitation MET|OTHER: Conventional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Epidural Dexmedetomidine vs Nalbuphine for Labor Analgesia
Status: COMPLETED
Conditions: Epidural Anesthesia|Labor Pain
Interventions: DRUG: Dexmedetomidine|DRUG: Nalbuphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer
Status: RECRUITING
Conditions: Advanced Solid Tumor|High Grade Serous Adenocarcinoma of Ovary|Squamous Non-small-cell Lung Cancer|Triple Negative Breast Cancer|Gastric Adenocarcinoma|Colorectal Adenocarcinoma|Esophageal Squamous Cell Carcinoma|Esophageal Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma|Transitional Cell Carcinoma of Bladder|Head and Neck Squamous Cell Carcinoma|Ovarian Carcinosarcoma|Uterine Carcinosarcoma|Uterine Serous Carcinoma|Endometrium Cancer|Chromosomal Instability
Interventions: DRUG: VLS-1488
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA
Status: RECRUITING
Conditions: Acromegaly|Gigantism|Familial Isolated Pituitary Adenoma|FIPA|Pituitary Adenoma Predisposition|PAP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Barley Supplemented Wheat Bread on Markers of Cardiovascular and Renal Health
Status: COMPLETED
Conditions: Cardiovascular Diseases|Kidney Diseases
Interventions: OTHER: Effect of Barley Supplemented Wheat Bread on markers of Cardiovascular and Renal Health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Azithromycin as an Adjunct to Non-Surgical Periodontal Treatment
Status: COMPLETED
Conditions: Periodontitis
Interventions: OTHER: Lactose tab|DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity, Safety of Measles-mumps-rubella-varicella Vaccine (MeMuRu-OKA) Compared to Priorix™ Given With Varilrix™
Status: COMPLETED
Conditions: Varicella|Rubella|Measles|Mumps
Interventions: BIOLOGICAL: MeMuRu-OKA (study vacc)|BIOLOGICAL: MMR, Varicella vacc (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Inhaled NO for the Treatment of COVID-19 Caused by SARS-CoV-2 (CANADA Trial)
Status: WITHDRAWN
Conditions: COVID-19|SARS-CoV 2|Respiratory Disease|Pneumonia, Viral|Corona Virus Infection
Interventions: COMBINATION_PRODUCT: 150 ppm Nitric Oxide delivered through LungFit Delivery System|COMBINATION_PRODUCT: 80 ppm Nitric Oxide delivered through LungFit Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FAU in Treating Patients With Advanced Solid Tumors or Lymphoma
Status: COMPLETED
Conditions: Adult Grade III Lymphomatoid Granulomatosis|Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Hodgkin Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Adult T-cell Leukemia/Lymphoma|Stage III Cutaneous T-cell Non-Hodgkin Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Mycosis Fungoides/Sezary Syndrome|Stage III Small Lymphocytic Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Adult T-cell Leukemia/Lymphoma|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Mycosis Fungoides/Sezary Syndrome|Stage IV Small Lymphocytic Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific|Waldenström Macroglobulinemia
Interventions: DRUG: 2'-F-ara-deoxyuridine|OTHER: positron emission tomography|OTHER: laboratory biomarker analysis|OTHER: pharmacological study|OTHER: pharmacogenomic studies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Exercise Program in Alzheimer's Patients With Mild to Moderate Stage Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer Disease|Aerobic Exercise|Breathing Exercise|Resistance Training
Interventions: OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The SUN Clinical Trial (Safety Utilizing NUsurface Meniscus Implant)
Status: ACTIVE_NOT_RECRUITING
Conditions: Post-Meniscectomy Pain Syndrome|Osteoarthritis, Knee
Interventions: DEVICE: NUsurface® Meniscus Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Pralsetinib Versus Standard of Care (SOC) for Treatment of RET-Mutated Medullary Thyroid Cancer (MTC).
Status: WITHDRAWN
Conditions: Medullary Thyroid Cancer
Interventions: DRUG: Pralsetinib|DRUG: Cabozantinib|DRUG: Vandetanib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Are Bright Lights and Regulated Sleep Effective Treatment for Depression?
Status: COMPLETED
Conditions: Sleep Phase Rhythm Disturbance|Sleep Deprivation
Interventions: BEHAVIORAL: Morning Light Therapy|BEHAVIORAL: Assigned Sleep Times|DEVICE: Goggles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Treatment of Resectable Adenocarcinoma of Esophagogastric Junction by Immunotherapy (Adebrelimab) Combined With Chemotherapy (XELOX): a Prospective, Single-center, Feasibility Study
Status: RECRUITING
Conditions: Esophagogastric Junction Adenocarcinoma
Interventions: DRUG: Adebrelimab (anti-PD-L1) + XELOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Multiple Sclerosis With Copaxone and Albuterol
Status: COMPLETED
Conditions: Autoimmune Diseases|Multiple Sclerosis
Interventions: DRUG: Glatiramer acetate|DRUG: Albuterol|DRUG: Albuterol placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Mixed-Methods Study of Multidimensional Adversity in Inner-City African American Adults With Chronic Kidney Disease and Type 2 Diabetes Mellitus
Status: RECRUITING
Conditions: Diabetic Nephropathy Type 2 - Uncontrolled|Diabetes Mellitus, Type 2|Chronic Kidney Diseases
Interventions: OTHER: Patient and Community Stakeholder Interviews|OTHER: Cross-sectional Study Participants|OTHER: Focus Groups and Intervention Mapping
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Validation of the American Orthopedic Foot and Ankle Society Midfoot Scale
Status: COMPLETED
Conditions: Foot
Interventions: DIAGNOSTIC_TEST: American Orthopedic Foot and Ankle Association Midfoot Scale, Foot and Ankle Ability Measure/FAAM, SF-12 Quality of Life Scale, Visual Analog Scale (VAS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cilengitide in Treating Patients With Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)
Interventions: DRUG: cilengitide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Radiation Therapy and T-Cell Infusion in Treating Patients With Metastatic Kidney Cancer
Status: TERMINATED
Conditions: Clear Cell Renal Cell Carcinoma|Recurrent Renal Cell Cancer|Stage IV Renal Cell Cancer
Interventions: RADIATION: stereotactic body radiation therapy|DRUG: cyclophosphamide|BIOLOGICAL: therapeutic autologous lymphocytes|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Vented Base Feeding Bottle in Preterm Infants With GERD Symptoms.
Status: COMPLETED
Conditions: GERD|Apnea Neonatal
Interventions: DEVICE: A|DEVICE: B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Platelet Resistance With Ticagrelor or Standard-Dose Clopidogrel Among CKD and ACS Patients
Status: UNKNOWN
Conditions: Acute Coronary Syndrome|Chronic Kidney Disease|End-Stage Renal Disease
Interventions: DRUG: Clopidogrel first|DRUG: Ticagrelor first
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Pressure Indicator Guided and a Conventional Bandaging in Treatment of Venous Leg Ulcer
Status: COMPLETED
Conditions: Venous Insufficiency
Interventions: DEVICE: customized pressure guide bandage|DEVICE: Ordinary elastic bandage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Impact of Genetic Testing on Clinical Decision Making and Patient Care
Status: UNKNOWN
Conditions: Pain|Chronic Pain|Mental Disorders|Cardiovascular Diseases|Diabetes Mellitus, Type 2|Arthritis
Interventions: OTHER: Unblinded to Genetic Testing Results|OTHER: Blinded to Genetic Testing Results
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study in Healthy Males to Measure Darunavir and Etravirine in Blood, Seminal Fluid, and Rectal Tissue
Status: COMPLETED
Conditions: HIV/AIDS|HIV Infections
Interventions: DRUG: darunavir|DRUG: Ritonavir|DRUG: Etravirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Collaborative Multidimensional Intervention for Depression in Chile
Status: UNKNOWN
Conditions: Depression
Interventions: OTHER: Collaborative Multidimensional Model (CMD)|OTHER: Standard Model (SM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Argatroban With Tissue Plasminogen Activator (tPA) for Acute Stroke
Status: TERMINATED
Conditions: Ischemic Stroke
Interventions: DRUG: Low Dose Argatroban|DRUG: High Dose Argatroban|DRUG: rt-PA (alteplase)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lavage of the Uterine Cavity for the Diagnosis of Serous Tubal Intraepithelial Carcinoma
Status: COMPLETED
Conditions: Ovarian Epithelial Cancer|Carcinoma in Situ|Ovarian Cancer
Interventions: PROCEDURE: Lavage of the Cavum uteri and proximal Fallopian tubes, performed in the luteal phase of the female cycle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Docetaxel Plus Cisplatin Followed by Gemcitabine Versus Gemcitabine Plus Cisplatin Followed by Docetaxel for Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Docetaxel, Cisplatin|DRUG: Gemcitabine, Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tranilast Combined With Minocycline in the Treatment of Rosacea
Status: ENROLLING_BY_INVITATION
Conditions: Rosacea
Interventions: DRUG: minocycline|DRUG: tranilast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CTSN Embolic Protection Trial
Status: RECRUITING
Conditions: Delirium|Ischemic Stroke|Acute Kidney Injury|Heart Valve Disease|Coronary Artery Disease
Interventions: DEVICE: CardioGard Embolic Protection Cannula|DEVICE: Standard Aortic Cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Double Blind, Placebo Controlled Trial of Quetiapine in Anorexia Nervosa, a Dual Site Study
Status: TERMINATED
Conditions: Anorexia Nervosa
Interventions: DRUG: quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of Biofinity Toric Versus Air Optix for Astigmatism
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: comfilcon A|DEVICE: lotrafilcon B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease
Interventions: DRUG: High dose potent statin|DRUG: ACE-I (lisinopril) or ARB (losartan)|DRUG: Aspirin|BEHAVIORAL: Lifestyle Counseling|BEHAVIORAL: Quality of Life Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Dose Vitamin D3 in Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Impact of the Food Support Program (Programa de Apoyo Alimentaria)
Status: COMPLETED
Conditions: Malnutrition
Interventions: OTHER: Cash + nutrition education|OTHER: Food basket + nutrition education|OTHER: Food basket w/o nutrition education|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: A Study to Measure CSF Proteins in Elderly Healthy Volunteers and Volunteers With Mild Cognitive Impairment or Alzheimer's Disease
Status: COMPLETED
Conditions: Healthy|Alzheimer Disease
Interventions: PROCEDURE: Standard CSR sampling procedure|PROCEDURE: Alternate frequency CSR sampling procedure|PROCEDURE: Standard frequent CSR sampling procedure with 800 mg ibuprofen|PROCEDURE: Standard CSR sampling procedure|PROCEDURE: Alternative lower frequency CSR sampling procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: High Protein Effect on Body Composition and Sarcopenia Markers in Older Patients With Type 2 Diabetes Mellitus
Status: UNKNOWN
Conditions: Type2 Diabetes Mellitus
Interventions: OTHER: 1.5 protein|OTHER: 0.8 protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I Combination of Midostaurin, Bortezomib, and Chemo in Relapsed/Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Acute Myeloid Leukemia With Multilineage Dysplasia Following|Myelodysplastic Syndrome|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Recurrent Adult Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia
Interventions: DRUG: midostaurin|DRUG: Bortezomib|DRUG: mitoxantrone hydrochloride|DRUG: etoposide|DRUG: cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Application of Methylene Blue for Treatment of Covid-19 Patients
Status: UNKNOWN
Conditions: Covid-19
Interventions: DRUG: MCN (Methylene blue, vitamin C, N-acetyl cysteine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Early Surgery and Maintenance of Antiplatelet Therapy on Intraoperative Bleeding and Major Adverse Cardiovascular Event After Percutaneous Coronary Intervention
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Drug-eluting Stent|Aspirin
Interventions: PROCEDURE: Non-cardiac surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of the Telomerase Vaccine GV1001 to Treat Patients With Inoperable Stage III Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Inoperable Stage III Non-small Cell Lung Cancer
Interventions: DRUG: GV1001|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability, Safety and Pharmacokinetics Study of GX-30 in Total Thyroidectomy or Near Total Thyroidectomy Patients
Status: COMPLETED
Conditions: Total Thyroidectomy|Near-total Thyroidectomy
Interventions: DRUG: Period 1 GX-30, Period 2 THYROGEN®|DRUG: Period 1 THYROGEN®, Period 2 GX-30
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination Chemotherapy in Treating Patients With Intermediate-Grade or High-Grade Non-Hodgkin's Lymphoma Who Have Not Responded to Anthracycline-Containing Combination Chemotherapy
Status: UNKNOWN
Conditions: Lymphoma
Interventions: DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Advancing Decisions About Virtual Service Encounters
Status: NOT_YET_RECRUITING
Conditions: Health Care Costs|Delivery of Health Care
Interventions: BEHAVIORAL: Clinician Coaching Sessions|OTHER: Personalized text messages to patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Real-time Tuberculosis Medication Adherence Intervention in Rural Southwestern Uganda
Status: UNKNOWN
Conditions: Tuberculosis
Interventions: OTHER: Daily SMS reminders for TB patients|OTHER: SMS Notifications for social supporters|OTHER: Weekly SMS remiders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Characterization of Placebo Responses in Stable Asthma
Status: COMPLETED
Conditions: Asthma Placebo Effects
Interventions: DRUG: albuterol|DRUG: placebo inhaler|PROCEDURE: placebo acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: rTMS-induced Cumulative Pattern of sBDNF in Chronic Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DEVICE: CR Technology, TAMAS for repetitive TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Incidence of Ventricular Arrhythmias in Patients With Chronic Total Occlusion Recanalization
Status: COMPLETED
Conditions: Chronic Total Occlusion of Coronary Artery
Interventions: DEVICE: Medtronic Reveal LINQ™ Insertable Cardiac Monitor (ICM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: N-Acetylcysteine in Neonatal Congenital Heart Surgery (INACT Study)
Status: COMPLETED
Conditions: Transposition of Great Vessels|Congenital Heart Disease
Interventions: DRUG: N-acetylcysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Orally Administered JNJ-440 to Evaluate the Safety, Tolerability, and Pharmacokinetics After Single Ascending Doses Including Food Effect Evaluation; After Multi-Day Dosing in Healthy Participants; and After Multiple (Ascending) Doses in Participants With Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: JNJ-440|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy in the Reduction of Hypersensitivity During Home Whitening With 16% Carbamide Peroxide Applied on Alternate Days
Status: RECRUITING
Conditions: Dental Hypersensitivity|Teeth Whitening
Interventions: OTHER: Daily whitening|OTHER: Alternate whitening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Somatosensory and Vestibular Rehabilitation Additional Conventional Therapy on Balance in Patients With Acute Stroke.
Status: COMPLETED
Conditions: Exercise|Acute Stroke
Interventions: BEHAVIORAL: Somatosensorial and Vestibular Exercises|BEHAVIORAL: Conventional Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Role of a Gluten Free-dairy Free (GFCF) Diet in the Dietary Management of Autism Associated Gastrointestinal Disorders
Status: COMPLETED
Conditions: Autism|Gastrointestinal Symptoms
Interventions: OTHER: GFCF product with GFCF diet|OTHER: product containing gluten and casein (milk protein) with GFCF diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Metformin as add-on Therapy in Non-Diabetic Heart Failure Patients
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Metformin Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dasotraline Binge Eating Disorder Study
Status: COMPLETED
Conditions: Binge Eating Disorder
Interventions: DRUG: Dasotraline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Renal Function and Hemodialysis on the Pharmacokinetics (PK) of RO7079901
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: RO7079901
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Milk Oligosaccharides (HMOs) Post-market Study on Infants (NEHMO)
Status: COMPLETED
Conditions: Growth|Tolerance|Adverse Event|Disorder of Intestine|Formula Satisfaction
Interventions: OTHER: HMO-supplemented infant formula
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Implementation of a Rapid Recovery Program in Gynecologic Oncology Surgery: A Pilot Study
Status: COMPLETED
Conditions: Cervical Cancer|Uterine Endometrial Cancer|Ovarian Cancer
Interventions: PROCEDURE: Laparotomy|DRUG: intravenous narcotics|DRUG: standard anesthesia|DRUG: regional anesthesia|DRUG: Non-steroidal anti-inflammatory drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety Study of Argatroban to Treat Heparin-Induced Thrombocytopenia
Status: COMPLETED
Conditions: Heparin-Induced Thrombocytopenia
Interventions: DRUG: argatroban
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Intraoperative and Postoperative Effects of Ultrasound-guided Erector Spina Plane Block and Posterior Quadratus Lumborum Block in Patients Undergoing Lumbar Stabilization Surgery
Status: COMPLETED
Conditions: Postprocedural Analgesia|Opioid Consumption|Erector Spina Plan Block|Quadratus Lumborum Block
Interventions: PROCEDURE: Peripheral nerve block
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of a Dietary Fiber on Fecal Microbiota and Metabolism
Status: COMPLETED
Conditions: Focus of the Study is on Gut Health
Interventions: DIETARY_SUPPLEMENT: Dietary Fiber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase III Study to Evaluate the Efficacy and Safety of Recombinant Botulinum Toxin Type A for Injection in the Treatment of Moderate to Severe Glabellar Lines
Status: COMPLETED
Conditions: Moderate to Severe Glabellar Lines
Interventions: BIOLOGICAL: Rcombinant botulinum neurotoxin type A for injection (YY001)|BIOLOGICAL: OnabotulinumtoxinA|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Forest Bathing in Vancouver, B.C. Parks
Status: COMPLETED
Conditions: Nature, Human|Mental Health Wellness 1|Stress, Psychological|Blood Pressure|Environmental Exposure|Anxiety
Interventions: BEHAVIORAL: Self-Guided Forest Bathing|BEHAVIORAL: Guided Forest Bathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: FeMoropopliteal AngioSculpt™ SCoring BallOon CaTheter Study
Status: COMPLETED
Conditions: Peripheral Arterial Occlusive Disease
Interventions: DEVICE: 4.0-5.0mm AngioSculpt Scoring Balloon Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Interaction Between Nevirapine and Methadone in HIV-1 Infected, Opioid-dependent Adults
Status: COMPLETED
Conditions: Acquired Immunodeficiency Syndrome
Interventions: DRUG: nevirapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immature Granulocyte [IG] Count and Percentage for Medical Treatment of Uncomplicated Acute Appendicitis
Status: COMPLETED
Conditions: Acute Appendicitis Without Peritonitis|Medical Emergencies
Interventions: DRUG: Cipro 400 MG in 200 ML Injection|DRUG: Flagyl I.V. RTU|PROCEDURE: appendectomy (open or laparascopic)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pelvic Floor Rehabilitation for Gynecological Cancer Patients
Status: UNKNOWN
Conditions: Malignant Female Reproductive System Neoplasm
Interventions: BEHAVIORAL: pelvic floor rehabilitation program with neuromodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma
Status: RECRUITING
Conditions: High Grade Glioma|Anaplastic Astrocytoma
Interventions: DRUG: DB107-RRV|DRUG: DB107-FC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Investigate the PK Profiles and Safety of CKD-385 in Healthy Volunteers Under Fasting Conditions
Status: UNKNOWN
Conditions: Cardiovascular Diseases
Interventions: DRUG: Reference drug|DRUG: Test drug 1|DRUG: Test drug 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality for Parent Training Intervention
Status: RECRUITING
Conditions: Attention-Deficit/Hyperactivity Disorder (ADHD)
Interventions: BEHAVIORAL: Parent training|BEHAVIORAL: Virtual Reality-assisted PT sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety of Ciclesonide Nasal Spray Administered With Inhaled Fluticasone Dipropionate/Salmeterol in Adults With Perennial Allergic Rhinitis (BY9010/M1-409)
Status: COMPLETED
Conditions: Perennial Allergic Rhinitis|Allergic Rhinitis|Hay Fever
Interventions: DRUG: Ciclesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Regorafenib Plus Tislelizumab as First-line Systemic Therapy for Patients With Advanced Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Advanced Hepatocellular Carcinoma
Interventions: DRUG: Tislelizumab+regorafenib for part 1;Tislelizumab+regorafenib for group 1 of part 2; Regorafenib for group 2 of part 2.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Protocolized Reduction of Non-resuscitation Fluids vs Usual Care in Septic Shock Feasibility Trial
Status: COMPLETED
Conditions: Shock, Septic
Interventions: OTHER: Protocolised reduction of non-resuscitation fluids|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of the Level of Dietary Protein on the Infant Hormonal Profile and Body Composition
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Low protein formula|OTHER: High protein formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Acetyl-L-Carnitine in the Treatment of Septic Shock
Status: COMPLETED
Conditions: Septic Shock
Interventions: DRUG: Acetyl-L-Carnitine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TRP Versus Photo Selective Vaporization for Obstructive Benign Prostatic Hyperplasia Management
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: PROCEDURE: TURP|PROCEDURE: PVP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Irradiation to the Contralateral Breast for BRCA Mutation Carriers Undergoing Treatment for Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: RADIATION: Prophylactic radiation to the contralateral breast
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Etomidate Plus Propofol, Etomidate Alone on Induction of Anesthesia
Status: COMPLETED
Conditions: Surgery
Interventions: DRUG: Propofol 2mg/kg|DRUG: Etomidate 0.3 mg/kg|DRUG: Propofol 1 mg/kg|DRUG: Etomidate 0.15 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 2% Chlorhexidine (CHX) vs CaOH2 (CH) Calcium Hydroxide Paste as an Intracanal Medicament
Status: NOT_YET_RECRUITING
Conditions: Apical Periodontitis
Interventions: DRUG: Chlorhexidine|DRUG: Calcium Hydroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Intramuscular PDA-002 in Subjects Who Have Diabetic Foot Ulcer With and Without Peripheral Arterial Disease
Status: TERMINATED
Conditions: Peripheral Arterial Disease|Diabetic Foot
Interventions: BIOLOGICAL: 3 x 10^6 cells|BIOLOGICAL: 10 x 10^6 cells|BIOLOGICAL: 30 x 10^6 cells|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Freedom® Total Knee System for Treatment of Osteoarthritis, Rheumatoid Arthritis or Post-traumatic Arthritis
Status: NOT_YET_RECRUITING
Conditions: Knee Osteoarthritis|Rheumatoid Arthritis|Post-traumatic Osteoarthritis
Interventions: DEVICE: Freedom® Total Knee System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect(s) of Sevelamer Carbonate (Renvela) on Atherosclerotic Plaque Inflammation Judged by FDG-PET Scan
Status: TERMINATED
Conditions: Dialysis|Cardiovascular Disease|Atherosclerosis|Inflammation|Hyperphosphatemia
Interventions: DRUG: Sevelamer Carbonate (Renvela)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Fluzoparib (SHR-3162) and Temozolomide With or Without SHR-1316 in Treating Patients With Replapsed Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Fluzoparib|DRUG: temozolomide|BIOLOGICAL: SHR-1316
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability of Different Formulations of BI 671800 in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 671800 HEA, 200 mg tablets|DRUG: BI 671800 HEA EC, 200 mg tablets|DRUG: BI 671800 HEA, 50 mg tablets|DRUG: BI 671800 ED, 100 mg capsules|OTHER: Standard meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Explore Safety And Tolerability of Fosamprenavir With or Without Ritonavir in Combination With TRIZIVIR or COMBIVIR
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: fosamprenavir|DRUG: COMBIVIR|DRUG: ritonavir|DRUG: TRIZIVIR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Aliya™ PEF Soft Tissue Ablation With Systemic Therapy in Early-Stage Resectable NSCLC
Status: TERMINATED
Conditions: NSCLC
Interventions: DEVICE: Aliya Pulsed Electric Fields (PEF) ablation|DRUG: Nivolumab plus Platinum Doublet Chemotherapy|DRUG: Standard of care neoadjuvant therapy|OTHER: Surgical Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine Bioequivalence of Isotretinoin in Healthy Male Subjects Under Fed Condition
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Isotretinoin: Reference Medication 1|DRUG: Isotretinoin: Reference Medication 2|DRUG: Isotretinoin: Test Medication
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Losartan Associated With Indapamide Versus Hyzaar® in the Hypertension Treatment
Status: SUSPENDED
Conditions: Hypertension
Interventions: DRUG: Indapamide / Losartan|DRUG: Indapamide / Losartan|DRUG: Hyzaar®|DRUG: Hyzaar®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Do Probiotics Reduce The Risk Of Severe Necrotising Enterocolitis (NEC) In Infants Born Before 32 Weeks Gestation?
Status: ENROLLING_BY_INVITATION
Conditions: Enterocolitis, Necrotizing
Interventions: DIETARY_SUPPLEMENT: Probiotics
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Local Overpressure Treatment for Meniere's Disease
Status: COMPLETED
Conditions: Meniere's Disease
Interventions: DEVICE: Meniett(C) device by MedTronic|DEVICE: placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preliminary Trial of the Effect of Glucocorticoid Receptor Antagonist on Borderline Personality Disorder (BPD)
Status: TERMINATED
Conditions: Borderline Personality Disorder
Interventions: DRUG: mifepristone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Ultrasonic Detection of a Novel Nasogastric Tube in the Human Body.
Status: NOT_YET_RECRUITING
Conditions: Nasogastric Tube Placement
Interventions: DEVICE: Nasotrak System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Intelligent Tutor Induced Pausing on Learning Simulated Surgical Skills
Status: RECRUITING
Conditions: Surgical Education
Interventions: BEHAVIORAL: Experimental Group ICEMS verbal feedback with pause group|BEHAVIORAL: Experimental Group ICEMS audio feedback with pause and expert video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: U.S. Guided Erector Spinae Block for Postoperative Pain Management in Paraumbilical Hernia Repair Patients
Status: NOT_YET_RECRUITING
Conditions: Regional Anesthesia
Interventions: DRUG: Bubpivacaine|DRUG: dexamethasone|DRUG: fentanyl
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comparative Effectiveness Trial of Optimal Patient-Centered Care
Status: COMPLETED
Conditions: Post Traumatic Concerns|Post Traumatic Stress Disorder|Depression and Suicide Ideation|Alcohol and Drug Use
Interventions: BEHAVIORAL: Stepped Care Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Early Use of Everolimus (EVE) on Cytomegalovirus (CMV) Infection in Renal Transplant Recipients
Status: UNKNOWN
Conditions: Cytomegalovirus Infections
Interventions: DRUG: Everolimus+Tacrolimus+Prednisone|DRUG: Mycophenolate+Tacrolimus+Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT