pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Efficacy Study of GS-5806 in Healthy Volunteers Infected With Respiratory Syncytial Virus (RSV)
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: DRUG: GS-5806|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MGCD0103 Administered in Combination With Azacitidine (Vidaza®) to Subjects With Relapsed or Refractory Hodgkin or Non-Hodgkin Lymphoma
Status: TERMINATED
Conditions: Hodgkin Lymphoma|Non-Hodgkin Lymphoma (Follicular or Large Diffuse B-cell Lymphoma or Mantle Cell Lymphoma)
Interventions: DRUG: MGCD0103 and Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ledipasvir/Sofosbuvir Fixed Dose Combination +/- Ribavirin in Adolescents and Children With Chronic HCV-Infection
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: LDV/SOF|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate Different Energy-based Devices for Aesthetic Treatments.
Status: RECRUITING
Conditions: Dermatologic Conditions
Interventions: DEVICE: Intense pulsed light.|DEVICE: Radiofrequency microneedling device|DEVICE: Radiofrequency device|DEVICE: Combined energy devices
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observation of Histological Changes in Parathyroid Adenomas Following High Intensity Focused Ultrasound (HIFU) Treatment Procedure
Status: COMPLETED
Conditions: Primary Parathyroid Adenomas
Interventions: DEVICE: Ultrasonic ablation device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate Patients With Cerebrotendinous Xanthomatosis (RESTORE)
Status: COMPLETED
Conditions: CTX
Interventions: DRUG: Blinded CDCA 250 mg TID|DRUG: Placebo|DRUG: Open-Label CDCA 250 mg TID|DRUG: Rescue Medication CDCA 250 mg TID|DRUG: CDCA Weight-Based Dose TID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Transverse Friction Massage in Latent Myofascial Trigger Points in Anterior Deltoid Muscle
Status: COMPLETED
Conditions: Myofascial Trigger Points|Myofascial Pain
Interventions: PROCEDURE: Transverse friction massage (TFM)|PROCEDURE: Transverse friction massage (TFM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Bupropion on Seizure Threshold in Depressed Patients
Status: COMPLETED
Conditions: MDD
Interventions: DRUG: Wellbutrin SR 300Mg Extended-Release Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of CKI for Oral Mucositis Caused by Radiotherapy for Head and Neck Cancer
Status: UNKNOWN
Conditions: Radiation-induced Oral Mucositis
Interventions: DRUG: Levofloxacin Injection|DRUG: Compound Kushen Injection（CKI）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Follow Up of Severely Malnourished Children (FUSAM)
Status: COMPLETED
Conditions: Severe Acute Malnutrition
Interventions: OTHER: NUTPSY treatment|OTHER: NUT treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-Center, Non-Controlled Clinical Study of Sorafenib Adjuvant Therapy in Advanced Renal-Cell Carcinoma
Status: UNKNOWN
Conditions: Renal Cell Carcinoma
Interventions: DRUG: sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketones in Heart Failure With Reduced Ejection Fraction
Status: ENROLLING_BY_INVITATION
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: DIETARY_SUPPLEMENT: ketone ester|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fluids in Sepsis and Septic Shock
Status: COMPLETED
Conditions: Sepsis|Septic Shock
Interventions: OTHER: higher chloride crystalloid|OTHER: higher chloride albumin|OTHER: lower chloride crystalloid|OTHER: lower chloride albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate Safety and Efficacy of ABT-335 in Combination With Rosuvastatin Calcium in Subjects With Multiple Abnormal Lipid Levels in the Blood
Status: COMPLETED
Conditions: Dyslipidemia|Coronary Heart Disease|Mixed Dyslipidemia
Interventions: DRUG: ABT-335|DRUG: Rosuvastatin Calcium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sintilimab and Lenalidomide as a Treatment for CAEBV
Status: UNKNOWN
Conditions: CAEBV
Interventions: DRUG: Sintilimab and lenalidomide|DRUG: Sintilimab placebo and lenalidomide placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Efficacy and Safety of Sildenafil in Men With Traumatic Spinal Cord Injury and Erectile Dysfunction
Status: COMPLETED
Conditions: Spinal Cord Injury|Erectile Dysfunction|Spinal Cord Trauma|Injuries, Spinal Cord|Impotence
Interventions: DRUG: sildenafil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Efficacy of Benralizumab in Subjects With Hypereosinophilic Syndrome
Status: UNKNOWN
Conditions: Respiratory System Agents|Anti-Asthmatic Agents|Hematologic Diseases|Leukocyte Disorders|Hypereosinophilia
Interventions: DRUG: benralizumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: [SENTRY] Tailoring Postoperative Management Through Sentinel Lymph Node Biopsy in Low- and Intermediate-Risk Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Cancer|Endometrial Neoplasms|Endometrial Adenocarcinoma|Endometrial Cancer Stage I|Endometrial Cancer Stage II|Endometrial Endometrioid Adenocarcinoma|Sentinel Lymph Node|Hysterectomy|Laparoscopic Hysterectomy
Interventions: PROCEDURE: Laparoscopic total hysterectomy with bilateral salpingo-oophorectomy and sentinel lymph node biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Participant Reported Preference for Subcutaneous Pembrolizumab Coformulated With Hyaluronidase (MK-3475A) Over Intravenous Pembrolizumab (MK-3475) Formulation in Multiple Tumor Types (MK-3475A-F11)
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer|Renal Cell Carcinoma|Melanoma
Interventions: BIOLOGICAL: Pembrolizumab co-formulated with hyaluronidase|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Next Day Effects of MK-4305 on Driving Performance (MK-4305-035 AM1)
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: MK-4305 40 mg|DRUG: MK-4305 20 mg|DRUG: Zopiclone|DRUG: Grossly Matching Placebo for Zopiclone|DRUG: Matching Placebo for MK-4305
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine Safety, Pharmacokinetics, Pharmacodynamics of BAY73-4506 in Combination With mFOLFOX6 or FOLFIRI
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: DRUG: Regorafenib (BAY73-4506)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Clinical Success of Restorations Using Different Magnification Aids
Status: COMPLETED
Conditions: Dental Caries
Interventions: DEVICE: Dental Loupe|DEVICE: Dental Operation Microscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Salts of Clopidogrel: Investigation to ENsure Clinical Equivalence
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Coronary Artery Disease|Ischemic Stroke|Peripheral Artery Disease|Carotid Artery Disease|Atrial Fibrillation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tofacitinib for the Treatment of Alopecia Areata and Its Variants
Status: COMPLETED
Conditions: Alopecia Areata|Alopecia Totalis|Alopecia Universalis
Interventions: DRUG: Tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Venovenous Hemofiltration Versus Conventional Treatment for Acute Severe Hypernatremia
Status: UNKNOWN
Conditions: Hypernatremia|Critically Ill
Interventions: PROCEDURE: continuous venovenous hemofiltration|DRUG: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I of OratecanTM in Combination With Capecitabine in Patients With Advanced Solid Malignancies
Status: COMPLETED
Conditions: Solid Tumor|Advanced Cancer
Interventions: DRUG: Oratecan and Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnosis and Staging of Typhoid Fever Using Surface-enhanced Raman Spectroscopy Liquid Biopsy
Status: ACTIVE_NOT_RECRUITING
Conditions: Typhoid Fever
Interventions: DIAGNOSTIC_TEST: Surface-enhanced Raman Spectroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Pancreas Cancer: Molecular Profiling as a Guide to Therapy Before and After Surgery ("Personalized Medicine")
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma
Interventions: DRUG: Milestone 1: Targeted chemotherapy prior to surgery|RADIATION: Milestone 2: Chemoradiotherapy (cXRT)|DRUG: Milestone 3: Targeted chemotherapy prior to surgery|RADIATION: Milestone 3: Chemoradiotherapy (cXRT)|DRUG: Milestone 4: standard FOLFIRINOX chemotherapy prior to surgery|RADIATION: Milestone 4: Chemoradiotherapy (cXRT)|DRUG: Milestone 5: Targeted chemotherapy after surgery|RADIATION: Milestone 5: Chemoradiotherapy (cXRT)|DRUG: Milestone 6: Gemcitabine after surgery|RADIATION: Milestone 6: Chemoradiotherapy (cXRT)|RADIATION: Milestone 7: Chemoradiotherapy (cXRT)|DRUG: Milestone 8: Targeted chemotherapy after surgery|DRUG: Milestone 9: Gemcitabine after surgery|OTHER: Milestone 10: No additional therapy after surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RIFT: Effect of Rifampicin on Plasma PK of FTC, TAF and Intracellular TFV-DP & FTC-TP
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Descovy® (TAF/FTC)|DRUG: Viread® (TDF)|DRUG: Rifadin® (Rifampicin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Oxaliplatin and Capecitabine on Top of Sorafenib Versus Sorafenib Alone in Advanced Hepatocellular Carcinoma Patients
Status: WITHDRAWN
Conditions: Hepatic Neoplasm Malignant
Interventions: DRUG: oxaliplatin (SR96669)|DRUG: capecitabine|DRUG: sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prognostic Value Serum Concentration of Indoxyl Sulfate During Acute Kidney Injury in Septic Shock Patients.
Status: RECRUITING
Conditions: Acute Kidney Injury|Septic Shock|Uremic; Toxemia|Mortality
Interventions: DIAGNOSTIC_TEST: Determination of the blood concentration of indoxyl sulfate (IS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Compare the Efficacy and Safety of Intrapleural Doxycycline Versus Iodopovidone for Performing Pleurodesis in Malignant Pleural Effusion
Status: COMPLETED
Conditions: Malignant Pleural Effusion
Interventions: OTHER: Doxycycline|OTHER: Iodopovidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Repetitive Transcranial Magnetic Stimulation as Therapy for Apathy in Amyotrophic Lateral Sclerosis
Status: WITHDRAWN
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DEVICE: rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III/IV Open-label Study of the Immunogenicity and Safety of a Single Dose of a Live Attenuated Influenza Vaccine (LAIV) (FluenzTM) for Each of Three Successive Years in Children naïve to, or in Previous Receipt of the AS03B Adjuvanted H1N1 (2009) Influenza Vaccine (Pandemrix ™).
Status: COMPLETED
Conditions: Live Attenuated Influenza Vaccine
Interventions: DRUG: Fluenz
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adressing PTSD Symptoms and Aggressive Behavior in Vulnerable Children in Burundi
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder|Aggressive Behavior
Interventions: BEHAVIORAL: Narrative Exposure Therapy for Forensic Offender Rehabilitation (FORNET)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-acupressure and Zhan Zhuang for Symptom Cluster Management
Status: RECRUITING
Conditions: Breast Cancer Female|Survivorship
Interventions: OTHER: zhan-zhuang|OTHER: self-acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Role of Rapid On-site Evaluation for Mutational Analysis of EBUS-TBNA Specimens
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: OTHER: Rapid on-site evaluation|DEVICE: EBUS-TBNA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: CD34+ Stem Cell Infusion to Augment Graft Function
Status: TERMINATED
Conditions: Waning Donor Chimerism|Waning Immune Function|Primary Immunodeficiency Disease(s)|Bone Marrow Failure
Interventions: BIOLOGICAL: CD34+
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of the Human Microbiome in Patients After Pancreatic Resection.
Status: NOT_YET_RECRUITING
Conditions: Pancreas Cancer|Pancreas Neoplasm|Pancreas Adenocarcinoma|Periampullary Cancer|Periampullary Carcinoma|Microbial Colonization
Interventions: PROCEDURE: Pancreatic resection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Vitamin K Supplementation on Circulating Levels of Osteocalcin on the Bone Metabolism and Aging
Status: UNKNOWN
Conditions: Bone Metabolism Disorder|Aging Disorder|Osteoporosis
Interventions: DIETARY_SUPPLEMENT: Vitamin K (MK7)|DRUG: Teriparatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Role of Energy Balance Modification on Health Responses in Chronic Lymphocytic Leukaemia
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Frailty|Muscle Function|Immune Function|Lipid Cell; Tumor
Interventions: BEHAVIORAL: HIT|BEHAVIORAL: EXE+ Nutritional Guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Influence of Using Vascularized Vaginal Flap on the Efficacy of Mesh-augmented Sacrospinous Hysteropexy
Status: RECRUITING
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: Sacrospinous hysteropexy with the synthetic mesh, vaginal flap and anterior colporrhaphy|PROCEDURE: Sacrospinous hysteropexy with the synthetic mesh and anterior colporrhaphy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adult Accuracy Study of the Enlite 3 Glucose Sensor
Status: COMPLETED
Conditions: Type 1 Diabetes|Type 2 Diabetes
Interventions: DEVICE: Enlite 3|DEVICE: Guardian Mobile App|DEVICE: 640G Insulin Pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: A Pharmacokinetic and Pharmacodynamic Study of PF-04950615 (RN316) in Subjects With Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia|Dyslipidemias|Hyperlipidemias|Lipid Metabolism Disorders|Metabolic Diseases
Interventions: BIOLOGICAL: PF-04950615 (RN316)|BIOLOGICAL: PF-04950615 (RN316)|BIOLOGICAL: PF-04950615 (RN316)|BIOLOGICAL: PF-04950615 (RN316)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical and Usability Study to Determine Safety and Efficacy of the Clear Device for Acne Treatment
Status: COMPLETED
Conditions: Monitor Acne Lessions Count Reduction as Result of Usinfg the Device
Interventions: DEVICE: light based device for treatment of acne
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Innovative Approaches to Assessment of Pain Control and Sedation in the NICU
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DEVICE: Waveguard (TM) EEG cap|DEVICE: Micro Movement Sensor|DEVICE: Pico Movement Sensor|DEVICE: QS Piezostimulator|DEVICE: tactileTM sensory evaluator
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Collagen-PVP vs Hylan G-F 20 in the Treatment of Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Osteoarthritis|Gonarthrosis
Interventions: DRUG: Collagen-PVP|DEVICE: Hylan G-F 20
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Resistance Training and Physical Functioning in Head and Neck Cancer Patients
Status: COMPLETED
Conditions: Head and Neck Cancer|Pharyngeal Cancer|Laryngeal Cancer
Interventions: BEHAVIORAL: Nutrition Counseling|BEHAVIORAL: Resistance Training and Nutrition Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Safety and Efficacy of Intravenous JNJ-64179375 Versus Oral Apixaban in Participants Undergoing Elective Total Knee Replacement Surgery
Status: COMPLETED
Conditions: VTE Prophylaxis With Anticoagulation After Total Knee Replacement Surgery
Interventions: DRUG: JNJ-64179375 0.3 mg/kg|DRUG: JNJ-64179375 0.6 mg/kg|DRUG: JNJ-64179375 1.2 mg/kg|DRUG: JNJ-64179375 (Dose to be Determined)|DRUG: JNJ-64179375 A mg/kg|DRUG: JNJ-64179375 B mg/kg|DRUG: JNJ-64179375 C mg/kg|DRUG: JNJ-64179375 D mg/kg|DRUG: Placebo JNJ-64179375|DRUG: Apixaban placebo|DRUG: Apixaban 2.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Telepsychoeducation for the Prevention of Emotional Distress in Professionals and Students From Essential Services in the Context of COVID-19
Status: UNKNOWN
Conditions: Mental Health Wellness 1|COVID|Emotional Distress|Depressive Symptoms|Anxiety Symptoms|Irritability|Telepsychotherapy
Interventions: BEHAVIORAL: Telepsychoeducation with personalized videos|BEHAVIORAL: Telepsychoeducation without personalized videos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: First-in-human Study to Evaluate the Safety and Immunogenicity of Three Dose Levels of the OVX033 Coronavirus Vaccine Candidate in Healthy Volunteers
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronavirus
Interventions: BIOLOGICAL: OVX033|BIOLOGICAL: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate ELU001 in Patients With Solid Tumors That Overexpress Folate Receptor Alpha (FRα)
Status: TERMINATED
Conditions: Ovarian Cancer|Ovarian Neoplasms|Ovarian Carcinoma|Endometrial Cancer|Ovary Cancer|Ovary Neoplasm|Ovary Disease|Ovary Metastasis|Ovarian Diseases|Ovarian Cancer Stage|Ovarian Epithelial Cancer|Ovarian Adenocarcinoma|Ovarian Serous Adenocarcinoma|Ovarian Neoplasm Epithelial|Ovarian Cancer Recurrent|Endometrial Diseases|Endometrial Adenocarcinoma|Endometrial Carcinosarcoma|Endometrial Clear Cell Adenocarcinoma|Endometrioid Adenocarcinoma|Endometrial Neoplasms|Endometrial Cancer Recurrent|Endometrioid Tumor|Fallopian Tube Cancer|Peritoneal Cancer
Interventions: DRUG: ELU001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Infrared Laser Stimulation (TILS) of Prefrontal Cognition in Post-traumatic Stress Disorder (PTSD)
Status: TERMINATED
Conditions: Post-traumatic Stress Disorder (PTSD)
Interventions: DEVICE: TILS|DEVICE: sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Coronary Drug Project
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Disease|Heart Diseases|Myocardial Infarction|Myocardial Ischemia
Interventions: DRUG: estrogen|DRUG: clofibrate clofibrate|DRUG: dextrothyroxine sodium|DRUG: niacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: An Investigation to Validate Speech Perception Assessment for Adult Cochlear Recipients Using a Mobile Research App
Status: RECRUITING
Conditions: Hearing Loss
Interventions: DEVICE: the Mobile Research App|OTHER: SOC/validated delivery of the speech perception test material
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Posterior-line Treatment With Disitamab Vedotin Plus PD-1 in Advanced HER2-low Expressing Gastric Cancer
Status: RECRUITING
Conditions: Gastric Cancer|HER2-low-expressing Gastric Cancer
Interventions: DRUG: Disitamab Vedotin|DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Depression Prevention Initiative - A Study of Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST) in School Settings
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: IPT-AST|BEHAVIORAL: Group Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase III Efficacy and Safety Study of Miconazole Oil for Otomycosis
Status: RECRUITING
Conditions: Otomycosis
Interventions: DRUG: Miconazole (2%) oil and mineral oil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retrospective Observational Study on Infective Complications and Outcome of Patients With ALL Treated With INO
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Infections|Bacterial Infections|Viral Infection|Fungal Infection|Acute Lymphoblastic Leukemia, Adult|Acute Lymphoblastic Leukemia, in Relapse
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SFX-01 in the Treatment and Evaluation of Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasm
Interventions: DRUG: SFX-01|DRUG: Fulvestrant|DRUG: Tamoxifen|DRUG: Aromatase Inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Pemetrexed and Carboplatin for Select Stage IB, II, and III Non-Squamous Non-Small-Cell Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Pemetrexed|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT Comparing Avatar Intervention to Supportive Intervention to Reduce Cannabis Use in Patients With Psychotic Disorders
Status: RECRUITING
Conditions: Psychotic Disorders|Cannabis Use Disorder|Mental Health Disorder
Interventions: OTHER: Avatar Intervention|OTHER: Addiction supportive intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aspirin for the Prevention of Preeclampsia in Women With Stage 1 Hypertension
Status: UNKNOWN
Conditions: Pre-Eclampsia
Interventions: DRUG: Aspirin 81mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Myocardial Ischemia and Transfusion Pilot
Status: COMPLETED
Conditions: Myocardial Infarction|Unstable Angina|Coronary Artery Disease
Interventions: BIOLOGICAL: Red blood cell transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Complete Digital Workflow for Construction of Full Arch Implant Supported Screw Retained Restoration
Status: ACTIVE_NOT_RECRUITING
Conditions: Prosthesis Durability
Interventions: DEVICE: Implant supported screw retained prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prospective Multicenter Clinical Study on the Visual and Refractive Outcomes and Safety Outcomes Following Implantation of an AddOn Intraocular Lens in Previously Pseudophakic Eyes
Status: RECRUITING
Conditions: Presbyopia|Refractive Errors|Residual Astigmatism
Interventions: DEVICE: supplementary intraocular lenses
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Study of ALS-L1023 in Patients With Abdominal Obesity of Metabolic Syndrome
Status: TERMINATED
Conditions: Abdominal Obesity Metabolic Syndrome
Interventions: DRUG: ALS-L1023|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Proof-of-Concept Study of Topical AC-203 in Patients With Bullous Pemphigoid
Status: TERMINATED
Conditions: Bullous Pemphigoid
Interventions: DRUG: AC-203 1% Topical Ointment|DRUG: Clobetasol 0.05% Topical Ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Mebo Versus Lidocane in Healing Time of Traumatic Oral Ulcer
Status: COMPLETED
Conditions: Mebo|Lidocaine|Healing|Traumatic Oral Ulceration
Interventions: DRUG: MEBO|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Orexin in Human Panic Disorder
Status: COMPLETED
Conditions: Panic Disorder
Interventions: DRUG: suvorexant|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intranasal Inhalations of M2 Macrophage Soluble Factors in Children With Developmental Speech Disorders
Status: COMPLETED
Conditions: Language Delay|Language; Developmental Disorder, Expressive|Language; Developmental Disorder, Receptive|Autism Spectrum Disorder|Attention Deficit-Hyperactivity Disorder|Speech Disorders in Children
Interventions: BIOLOGICAL: Bioactive Factors, Produced by M2 Type Macrophages (M2-BFs).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Assesment of Patients Operated for Hypospadias in Their Childhood : Urinary, Aesthetical, Sexual and Psycho-social Consequences
Status: RECRUITING
Conditions: Hypospadias
Interventions: OTHER: Urethral stenosis assesment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Evaluate Sub-retinal Transplantation of Retinal Pigmented Epithelial Cells in Patients With Dry AMD
Status: WITHDRAWN
Conditions: Age-Related Macular Degeneration
Interventions: BIOLOGICAL: Sub-retinal transplantation of MA09-hRPE cells|DRUG: tacrolimus and mycophenolate mofetil|DRUG: Placebo tacrolimus and mycophenolate mofetil|PROCEDURE: Sham Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III, Randomized, Study of Aspirin and Esomeprazole Chemoprevention in Barrett's Metaplasia
Status: UNKNOWN
Conditions: Esophageal Cancer|Precancerous Condition
Interventions: DRUG: Esomeprazole|DRUG: Esomeprazole|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Drug Interaction Study of Apixaban With Cyclosporine and Tacrolimus
Status: COMPLETED
Conditions: Venous Thromboembolism|Pharmacokinetics|Healthy
Interventions: DRUG: Apixaban alone|DRUG: Cyclosporine|DRUG: Tacrolimus|DRUG: Apixaban|DRUG: Apixaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Superimposed Electrical Stimulation on Sitting Balance, Respiratory Functions, and Abdominal Muscle Thickness in Complete Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury Thoracic
Interventions: DEVICE: NeuroTrac MyoPlus Pro single-channel electromyography biofeedback electrotherapy devices|OTHER: Isometric strengthening exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Appendectomy by Multi-port vs Single Port.
Status: UNKNOWN
Conditions: Acute Appendicitis
Interventions: PROCEDURE: Single incision laparoscopic appendectomy|PROCEDURE: Multiport laparoscopic appendectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pectoralis and Serratus Nerves Block in Thoracic Surgery
Status: UNKNOWN
Conditions: Anesthesia|Surgery|Block|Thoracic Injury
Interventions: DRUG: Bupivacaine Hydrochloride|DEVICE: Ultrasound|PROCEDURE: Thoracotomy|DRUG: Opioids|DRUG: NSAID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: To Evaluate the Efficacy and Safety of FE 999315 in Japanese Subjects With Mild to Moderate Active Ulcerative Colitis
Status: COMPLETED
Conditions: Colitis, Ulcerative
Interventions: DRUG: Budesonide (6 mg)|DRUG: Budesonide (9 mg)|DRUG: Mesalazine (3,600 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Imiquimod 5% Cream in Addition to Cryotherapy in the Management of Actinic Keratoses
Status: COMPLETED
Conditions: Keratosis|Actinic Keratosis
Interventions: DRUG: Imiquimod used as an adjunct to cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Coping Skills Program for Children With Asthma
Status: RECRUITING
Conditions: Asthma in Children
Interventions: BEHAVIORAL: Combined coping skills + asthma management|BEHAVIORAL: Standard Asthma Management (AM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block in Radical Cystectomy
Status: COMPLETED
Conditions: Erector Spinae Plane Block|Radical Cystectomy
Interventions: DRUG: Bupivacain 25% (Erector Spinae Plane Block)|DRUG: Morphine (Intravenous patient-controlled analgesia)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Multi-component Intervention in Frail Community-dwelling Older People
Status: UNKNOWN
Conditions: Frail Elderly|Exercise Therapy|Physical Therapy Techniques
Interventions: OTHER: Exercise - FIRST PHASE|OTHER: Exercise - SECOND PHASE|OTHER: Exercise - FOURTH PHASE|OTHER: Exercise - THIRD PHASE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation for BECTS
Status: RECRUITING
Conditions: Benign Epilepsy With Centrotemporal Spikes|Language Problems|Learning Disorders
Interventions: DEVICE: Active rTMS|DEVICE: Sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mobilization and Handling of Stem Cells for Transplant From Healthy Volunteers With Sickle Cell Trait
Status: COMPLETED
Conditions: Sickle Cell Trait
Interventions: DRUG: Granulocyte colony-stimulating factor|PROCEDURE: Leukapheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation of Effect of Alirocumab on Coronary Atheroma Volume in Japanese Patients Hospitalized for Acute Coronary Syndrome With Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia|Acute Coronary Syndrome
Interventions: DRUG: Alirocumab SAR236553|DRUG: Atorvastatin|DRUG: Rosuvastatin|DRUG: Fenofibrate|DRUG: Bezafibrate|DRUG: Ezetimibe|DRUG: Antiplatelets|DRUG: Anticoagulants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Colonoscope Insertion Trial Protocol
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DEVICE: Colonoscopy with Olympus Technically Improved Colonoscope|DEVICE: Control with standard colonoscope Olympus CF-H180
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Olaparib Monotherapy in Relapsed Small Cell Lung Cancer Patients With HR Pathway Gene Mutations Not Limited to BRCA 1/2 Mutations, ATM Deficiency or MRE11A Mutations
Status: COMPLETED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iadademstat in Combination With Azacitidine and Venetoclax in Treating Newly Diagnosed Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome/Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Echocardiography|DRUG: Iadademstat|PROCEDURE: Multigated Acquisition Scan|OTHER: Questionnaire Administration|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Following of Myeloid-derived Suppressor Cells (MDSC) in Severe Sepsis: What Relationship With Systemic Inflammatory Syndrome?
Status: TERMINATED
Conditions: Severe Sepsis|Inflammatory Response Syndrome, Systemic
Interventions: BIOLOGICAL: Residue of blood further to NFS|BIOLOGICAL: Residue of blood further to preoperative workup|BIOLOGICAL: Bone marrow collected during a myelogram carried out for hematological pathology workup|BIOLOGICAL: Bone marrow collected during myelogram routinely performed during hospitalization in ICU
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Topical Sunscreen Plus Antioxidant Against the Visible Light Biological Effects
Status: COMPLETED
Conditions: Pigmentation
Interventions: OTHER: Topical Product A|OTHER: Topical Product B|OTHER: Topical Product C|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: SPONGIT: Comparison of Two Surgical Approaches in the Treatment of Degenerative Spondylolysthesis
Status: COMPLETED
Conditions: Degenerative Spondylolisthesis
Interventions: PROCEDURE: Circumferential arthrodesis|PROCEDURE: Posterolateral fusion with instrumentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamics Of Product Octreotide Acetate Lar 30 Mg Compared To Product Sandostatin LAR ®
Status: SUSPENDED
Conditions: Acromegaly
Interventions: DRUG: Octreotide acetate LAR|DRUG: Sandostatin LAR ® (octreotide acetate LAR) 30 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunoadsorption Versus Immunoglobulins for Treatment of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Status: RECRUITING
Conditions: CIDP
Interventions: DEVICE: Immunoadsorption|BIOLOGICAL: Immunoglobulins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Temozolomide and Atezolizumab as Second or Third Line for the Treatment of Metastatic or Recurrent Small Cell Lung Cancer
Status: RECRUITING
Conditions: Extensive Stage Lung Small Cell Carcinoma|Metastatic Lung Small Cell Carcinoma|Recurrent Lung Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: BIOLOGICAL: Atezolizumab|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of MAF-1217 in Patients With DED
Status: COMPLETED
Conditions: Evaporative Dry Eye Disease
Interventions: DEVICE: MAF1217|OTHER: Cationorm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of TAK-875 in Adults With Type 2 Diabetes and Cardiovascular Disease or Risk Factors for Cardiovascular Disease
Status: TERMINATED
Conditions: Type 2 Diabetes|Cardiovascular Disease
Interventions: DRUG: TAK-875|DRUG: TAK-875 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Insulin Requirement Post Cardiac Surgery Predicts The Risk Of Developing Diabetes
Status: UNKNOWN
Conditions: Diabetes|Pre-diabetes
Interventions: DIAGNOSTIC_TEST: Checking diabetes development in follow up at 3 month
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Primary EUS-GBD in Patients With Unresectable Malignant Biliary Obstruction and Cystic Duct Orifice Involvement.
Status: COMPLETED
Conditions: Acute Cholecystitis
Interventions: PROCEDURE: EUS-guided gallbladder drainage|PROCEDURE: Non EUS-guided gallbladder drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Probiotics in NASH Patients - PROBILIVER TRIAL
Status: UNKNOWN
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Emotion Regulation Interventions for Preventing Collegiate Escalations in Drinking
Status: UNKNOWN
Conditions: Alcohol Abuse
Interventions: BEHAVIORAL: Yoga|BEHAVIORAL: Distress Tolerance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Circulating Exosomes and Endothelial Dysfunction in Patients With Obstructive Sleep Apneas Hypopneas Syndrome
Status: COMPLETED
Conditions: Endothelial Dysfunction
Interventions: DIAGNOSTIC_TEST: ENDOPAT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Contrast Media on Subjects With Stable Reduced Renal Function Undergoing Contrast-Enhanced Computed Tomography
Status: TERMINATED
Conditions: Renal Impairment
Interventions: DRUG: Ioversol 320 mgI/mL|DRUG: Iodixanol 320 mgI/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: VRC 309: A Multi-Center, Open-Label, Randomized Phase I Study of an Investigational Influenza DNA Vaccine Followed by 2009/2010 Seasonal Influenza Trivalent Inactivated Vaccine (TIV) Compared to Two Injections of TIV in Adults 45-70 Years
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: VRC-FLUDNA056-00VP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Cocaine Dependence With Lisdexamfetamine
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: lisdexamfetamine/Behavior Therapy|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cross-legged Versus Traditional Sitting Position for the Success of Epidural Analgesia During Labor
Status: COMPLETED
Conditions: Epidural Analgesia for Labour and Delivery
Interventions: OTHER: Position of labouring women for epidural analgesia catheter placement : Traditional Sitting Position (TSP)|OTHER: Position of labouring women for epidural analgesia catheter placement : Cross-legged Sitting Position (CSP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: APG-2575 Study of Safety, Tolerability ,PK/PD in Patients With Hematologic Malignancies
Status: RECRUITING
Conditions: Hematologic Malignancies
Interventions: DRUG: APG-2575
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Trial Measuring Satisfaction And Convenience Of Two Formulations Of Lamotrigine In Subjects With A Mood Disorder
Status: COMPLETED
Conditions: Mood Disorders
Interventions: DRUG: Lamotrigine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Activity and Changes in Eating (PACE) to Reduce Obesity
Status: COMPLETED
Conditions: Obesity|Cardiovascular Diseases|Heart Diseases
Interventions: BEHAVIORAL: Diet|BEHAVIORAL: Exercise|BEHAVIORAL: Environment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Inhalation of Low Concentration of CO2 in Preterm Infants Not Responding to Caffeine for the Treatment of Apnea
Status: TERMINATED
Conditions: Apnea of Prematurity
Interventions: OTHER: Inhalation of low concentration of CO2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-dispensing Study to Check Prescription Equivalence of Two Daily Disposable Toric Contact Lens Types
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: etafilcon A toric contact lens with new wetting agent|DEVICE: etafilcon A toric contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Blueberry Consumption Improves Vascular Function and Lowers Blood Pressure in Postmenopausal Women With Pre- and Stage 1-hypertension
Status: COMPLETED
Conditions: Blood Pressure
Interventions: DIETARY_SUPPLEMENT: Freeze-dried Blueberry Powder|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT