pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Clinical Outcomes of Bonded Monolithic Translucent Zirconia Crowns Using Two Different Compositions of Self-adhesive Resin Cements
Status: UNKNOWN
Conditions: Destructed Teeth Restored by Zirconia Crowns|Zirconia Crowns|Decayed, Missing, and Filled Teeth|Tooth Discoloration
Interventions: OTHER: TheraCem self-adhesive resin cement|OTHER: Multilink adhesive resin cement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Pilocarpine HCl Ophthalmic Solution (AGN-190584) in Participants With Presbyopia
Status: COMPLETED
Conditions: Presbyopia
Interventions: OTHER: Vehicle|DRUG: Pilocarpine HCl Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pars Plana Vitrectomy (PPV) Versus Preoperative Intravitreal Bevacizumab Plus PPV to Treat Diabetic Tractional Retinal Detachment (IBETRA)
Status: COMPLETED
Conditions: Diabetic Retinopathy|Retinal Detachment
Interventions: DRUG: Bevacizumab|PROCEDURE: pars plana vitrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Human Bioequivalence of Oseltamivir Phosphate For Oral Suspension
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Oseltamivir Phosphate For Oral Suspension/Tamiflu|DRUG: Oseltamivir Phosphate For Oral Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Dry Needling on Autonomic Nervous System and Nociceptive Pain Processing in Neck Pain
Status: COMPLETED
Conditions: Neck Pain
Interventions: OTHER: Real Dry Needling|OTHER: Sham Dry Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Value of Technology to Transfer Discharge Information
Status: COMPLETED
Conditions: Information Dissemination|Interprofessional Relations
Interventions: DEVICE: Discharge communication software|OTHER: Usual care discharge process
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Feasibility of a Clinician Training Program to Improve Patient-provider Communication in the Presence of Health IT Systems in the Exam Room
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: EHR-Physician Asthma Care Education Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Compare ELP in Patients With Elective Phaco-VTX Surgery in One Eye and a Single Lens Phaco Surgery on the Other Eye
Status: COMPLETED
Conditions: Macular Pucker
Interventions: PROCEDURE: phaco-vitrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HM-178: Assessing Methods for Improvement in Methotrexate Toxicity Management and Detection of Central Nervous System Involvement of Aggressive Lymphoma
Status: SUSPENDED
Conditions: Lymphoma
Interventions: DRUG: Glucarpidase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study of 9-Aminocamptothecin (9-AC) in Patients With Refractory Leukemia
Status: COMPLETED
Conditions: Leukemia, Myelocytic, Acute|Acute Lymphocytic Leukemia
Interventions: DRUG: 9-Aminocamptothecin (9-AC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The TAPS Trial - Fetoscopic Laser Surgery for Twin Anemia Polycythemia Sequence
Status: UNKNOWN
Conditions: Twin Anemia Polycythemia Sequence
Interventions: PROCEDURE: Fetoscopic Laser Surgery|OTHER: Standard Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myo-inositol During Pregnancy to Prevent Gestational Diabetes
Status: NOT_YET_RECRUITING
Conditions: Pregnancy Related
Interventions: DIETARY_SUPPLEMENT: Myo-inositol|DIETARY_SUPPLEMENT: Myo-inositol placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Combined CFRT and SABR in Stage II and III NSCLC With Peripheral Tumors Smaller Than 5 cm.
Status: COMPLETED
Conditions: Inoperable Locally Advanced Non Small Cell Lung Cancer
Interventions: RADIATION: SABR|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Efficacy and Safety of Vitamin C for Iron Supplementation in Adult IDA Patients
Status: COMPLETED
Conditions: Anemia, Iron-Deficiency
Interventions: DRUG: ferrous succinate and vitamin C|DRUG: ferrous succinate|DRUG: ferrous succinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of the Ambu AuraGain Versus LMA Supreme in Children
Status: COMPLETED
Conditions: Supraglottic Airway
Interventions: DEVICE: Ambu AuraGain (size 1.5 or size 2.0)|DEVICE: LMA Supreme (size 1.5 or size 2.0)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: NIV Versus HFO Versus Standard Therapy Immediately After Weaning From Mechanical Ventilation in ARDS Patients
Status: COMPLETED
Conditions: Mechanical Ventilation Complication|Weaning Failure|Acute Respiratory Distress Syndrome|High-flow Oxygenation
Interventions: DEVICE: Respiratory support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase III Study of Abatacept (BMS-188667) in Patients With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Abatacept|DRUG: Methotrexate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Electrical Vestibular Nerve Stimulation (VeNS) Compared to Sham Control as a Means of Improving Glycemic Control in Adults With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DEVICE: Vestal DM Active device|BEHAVIORAL: Lifestyle modification|DEVICE: Vestal DM Sham device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Health and Wellness in Healthcare Providers Post-disaster
Status: COMPLETED
Conditions: Intervention 1: Resilience and Coping for Healthcare Group|Intervention 2: Resilience and Coping for Healthcare Plus Additional Services|Waitlist Control Group
Interventions: BEHAVIORAL: RCHC|BEHAVIORAL: RCHC+|OTHER: Waitlist control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Diagnostic Validity of [18F]FSPG PET for the Assessment of Disease Activity in Inflammatory Bowel Disease
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases|Ulcerative Colitis|Crohn Disease
Interventions: DRUG: [18F]FSPG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prophylaxis Of Wound Infections- Antibiotics in Renal Donation
Status: COMPLETED
Conditions: Infection
Interventions: DRUG: Co-Amoxiclav|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Computerized Cognitive Behavioral Therapy Assisted Life Management for Pain in Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease|Chronic Pain
Interventions: BEHAVIORAL: cognitive behavioral therapy|BEHAVIORAL: eEducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Micafungin Given Twice Weekly Intravenously Compared to Micafungin Given Daily to Patients at Risk for Developing an Invasive Fungal Disease
Status: COMPLETED
Conditions: Acute Graft Versus Host Disease Grade II-IV|Allogeneic Stem Cell Transplant|Acute Myeloid Leucaemia|Myelo Dysplastic Syndrome
Interventions: OTHER: alternate dosing|OTHER: daily dosing|DRUG: micafungin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Language, Speech and Motor Function in MCI Due to AD and Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer's Disease|MCI Due to AD|Dementia Alzheimers
Interventions: BEHAVIORAL: GAITRite walkway system OR 4-meter walking speed test|BEHAVIORAL: Jamar hand dynamometer|BEHAVIORAL: Picture description task|BEHAVIORAL: Autobiographical semi-structured conversation|BEHAVIORAL: Verbal fluency
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dexmedetomidine Infusion Versus Oral Melatonin for Prevention of Intensive Care Delirium
Status: RECRUITING
Conditions: Dexmedetomidine|Melatonin|Delirium
Interventions: DRUG: Dexmedetomidine|DRUG: Melatonin 3 MG|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of a Dietary Supplement in Females With Cellulite
Status: TERMINATED
Conditions: Cellulite (Orange Peel Skin)
Interventions: DIETARY_SUPPLEMENT: dietary supplement for cellulite (PUFA, resveratrol, lycopene, beta carotene, lutein)|DIETARY_SUPPLEMENT: Viatmin E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DuraMesh Laparotomy Study
Status: WITHDRAWN
Conditions: Laparotomy|Suture; Complications, Mechanical|Hernia Incisional
Interventions: DEVICE: Duramesh suturable mesh for laparotomy closure|DEVICE: Conventional suture for laparotomy closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab After SBRT Versus Pembrolizumab Alone in Advanced NSCLC
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: pembrolizumab|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic (PK) Study of GSK933776 in Healthy Volunteers
Status: COMPLETED
Conditions: Atrophy, Geographic
Interventions: DRUG: GSK933776 for SQ administration|DRUG: GSK933776 for IM administration|DRUG: GSK933776 for IV administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Probiotics to Extremely Low Birth Weight Prematures
Status: COMPLETED
Conditions: Feeding; Difficult, Newborn|Growth Failure|Necrotizing Enterocolitis|Sepsis
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: NT-proBNP in the Management of Discharged Patients With Acutely Decompensated Heart Failure and Preserved Ejection Fraction
Status: COMPLETED
Conditions: Heart Failure|Preserved Left Ventricular Ejection Fraction
Interventions: OTHER: NT-proBNP (Cardiac Biomarkers)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Co-administration Study of an Investigational Live-Attenuated Respiratory Syncytial Virus Vaccine in Infants and Toddlers
Status: RECRUITING
Conditions: RSV Immunization
Interventions: BIOLOGICAL: RSVt vaccine|BIOLOGICAL: Diphtheria, tetanus, pertussis, poliomyelitis , Haemophilus influenzae type b, and hepatitis B vaccine|BIOLOGICAL: Diphtheria, tetanus, pertussis, Haemophilus influenzae type b and poliomyelitis vaccine|BIOLOGICAL: Hepatitis B vaccine|BIOLOGICAL: Streptococcus pneumoniae vaccine|BIOLOGICAL: Rotavirus vaccine|BIOLOGICAL: Measles, mumps, and rubella vaccine|BIOLOGICAL: Varicella virus vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Understanding the Roles of Hormones in Adipocyte Remodeling Following Menopause
Status: WITHDRAWN
Conditions: Menopause Surgical|Estrogen Deficiency|Adiposity|Follicle-Stimulating Hormone Deficiency|Hormone Deficiency
Interventions: PROCEDURE: 'Surgical Menopause' Group|DRUG: 'Drug-Induced Menopause' Group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nab-paclitaxel Compared With Docetaxel Followed by Anthracyclines and Cyclophosphamide in the Neoadjuvant Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: nab-paclitaxel followed by anthracycline and cyclophosphamide|DRUG: Docetaxel followed by anthracycline and cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accuracy of the Transpatellar Tendon Approach to Knee Arthrocentesis
Status: COMPLETED
Conditions: Knee Aspiration
Interventions: PROCEDURE: Transpatellar Approach|PROCEDURE: Suprapatellar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Specificity Trial of the Recombinant Tuberculosis Allergen in BCG Vaccinated Healthy Volunteers
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DIAGNOSTIC_TEST: Recombinant tuberculosis allergen (RTA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Acute Responses of Active Video Games and Traditional Exercise Program in in Patients With Pulmonary Hypertension
Status: RECRUITING
Conditions: Pulmonary Hypertension
Interventions: OTHER: Active Video Games Intervention|OTHER: Traditional Exercise Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CK-2127107 in Patients With Spinal Muscular Atrophy
Status: COMPLETED
Conditions: Spinal Muscular Atrophy
Interventions: DRUG: Placebo|DRUG: Reldesemtiv 150 mg|DRUG: Reldesemtiv 450 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endophthalmitis After Intravitreal Injection of Antiangiogenic Agents or Corticosteroids, a Cohort Study of the French Population of Patients Who Received Injections Over 9 Years
Status: COMPLETED
Conditions: Intravitreal Injection
Interventions: OTHER: Data collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hybrid Dose-fraction Radiotherapy for Metastatic Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Hybrid dose-fraction Radiotherapy combined with immune checkpoint inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An RCT Evaluating the Efficacy of a Skincare Routine and Acne Supplement on Improving Acne and Other Symptoms of PMS
Status: COMPLETED
Conditions: Acne|Premenstrual Syndrome
Interventions: OTHER: Skincare Routine|DIETARY_SUPPLEMENT: MINDBODYSKIN Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Tolerability of Beclometasone/Formoterol Single Inhaler in Patients With Moderate to Severe Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: beclomethasone/formoterol (100/6µg) pMDI|DRUG: Beclometasone dipropionate 250 µg/unit dose pMDI|DRUG: Formoterol powder 12 µg/unit dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of a Predictive Model of Response to Romiplostim in Patients With IPSS Low or Intermediate-1 Risk MDS and Thrombocytopenia
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: N-Plate / romiplostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plantar Cutaneous Sensory Stimulation in Patients With Diabetic Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathies
Interventions: OTHER: Traditional physical therapy|OTHER: Plantar cutaneous sensory stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Laser Tissue Welding - Distal Pancreatectomy Sealing Study
Status: COMPLETED
Conditions: Pancreatic Tumor, Benign|Pancreatic Neoplasms|Pancreatic Adenocarcinoma|Pancreatic Pseudocyst|Pancreatic Neuroendocrine Tumor|Pancreas; Insulinoma|Pancreatic Cyst|Pancreatic Teratoma|Pancreatic Polypeptide Tumor|Pancreatic Vipoma|Pancreatic Cystadenoma|Pancreas Injury|Pancreatic Gastrinoma|Pancreatic Glucagonoma
Interventions: DEVICE: Distal Pancreatectomy Sealing Using LTW
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Comparison of Bolus Versus Continuous Infusion of Terlipressin Cirrhotic Patients With Septic Shock.
Status: UNKNOWN
Conditions: Liver Cirrhosis
Interventions: DRUG: Terlipressin|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Depressive Symptoms in Older Individuals in Isolation During Covid-19
Status: TERMINATED
Conditions: Depression|Depressive Symptoms
Interventions: BEHAVIORAL: Brief Behavioral Activation with Mental Imagery|BEHAVIORAL: Minimal Attention Control Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Montelukast for Persistent Cough in Young People and Adults
Status: UNKNOWN
Conditions: Persistent Cough|Whooping Cough
Interventions: DRUG: Montelukast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of the Use of Hearing Protection in the Salivary Cortisol Level and in the Sleep of Premature Infants
Status: UNKNOWN
Conditions: Premature Newborn
Interventions: DEVICE: use of earmuffs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase II Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Therapy
Status: RECRUITING
Conditions: Rectal Adenocarcinoma
Interventions: DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity & Reactogenicity of Boostrix 10 Years After Previous Booster Vaccination.
Status: COMPLETED
Conditions: Acellular Pertussis|Tetanus|Diphtheria
Interventions: BIOLOGICAL: Boostrix TM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Just-In-Time Intervention to Reduce Alcohol-Facilitated Intimate Partner Violence Perpetration
Status: RECRUITING
Conditions: Alcohol Drinking|Aggression|Emotion Regulation
Interventions: BEHAVIORAL: Alcohol Skills and Emotion Regulation Intervention|OTHER: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Atorvastatin in Chronic Subdural Haematoma
Status: UNKNOWN
Conditions: Chronic Subdural Hematoma
Interventions: DRUG: Atorvastatin 20mg|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: rPMS Compared With Pelvic Floor Exercises for Treatment of Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: DEVICE: rPMS device|PROCEDURE: Pelvic floor muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transplantation of Human iPS Cell-derived Dopaminergic Progenitors (CT1-DAP001) for Parkinson's Disease (Phase I/II)
Status: RECRUITING
Conditions: PD - Parkinson's Disease
Interventions: COMBINATION_PRODUCT: Human induced pluripotent stem cell-derived dopaminergic progenitors (CT1-DAP001)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of T3011 Administered Via Intravenously in Patients With Advanced Solid Tumors.
Status: RECRUITING
Conditions: Advanced Solid Tumor|Lung Cancer|Liver Cancer|Lymphoma|Mesothelioma of Pleura
Interventions: BIOLOGICAL: T3011
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temsirolimus and Bevacizumab in Hormone-Resistant Metastatic Prostate Cancer That Did Not Respond to Chemotherapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: temsirolimus|BIOLOGICAL: bevacizumab|GENETIC: polymorphism analysis|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Participants With Type 2 Diabetes Mellitus (AWARD-4)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin Glargine|DRUG: LY2189265|DRUG: Insulin Lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Synergism of Phytonutrients, Curcumin and Ursolic Acid, to Target Molecular Pathways in the Prostate
Status: WITHDRAWN
Conditions: Prostate Cancer
Interventions: DRUG: Ursolic Acid|DRUG: Curcumin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effectiveness of Various Teaching Methods to Enhance the Comprehensive Nursing Assessment Skills of New Nurses
Status: NOT_YET_RECRUITING
Conditions: Competence
Interventions: OTHER: Nursing health assessment teaching and discussion using humanoid diagrams|OTHER: Nursing health assessment teaching and discussion using case study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Small Bowel Diversion
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Type2 Diabetes
Interventions: PROCEDURE: jejuno-ileal diversion|PROCEDURE: jejuno-colic diversion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Topiramate Augmenting Strategies for the Treatment of Alcohol Use Disorder
Status: UNKNOWN
Conditions: Alcoholism
Interventions: DRUG: Topiramate and N-Acetyl Cysteine|DRUG: Topiramate and Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy of Boric Acid Mouthwashes in Different Concentrations
Status: ACTIVE_NOT_RECRUITING
Conditions: Impacted Third Molar Tooth
Interventions: DRUG: Chlorhexidine mouthwash|PROCEDURE: Chlorhexidine mouthwash with boric acid (0.1%)|PROCEDURE: Chlorhexidine mouthwash with boric acid (0.5%)|PROCEDURE: Chlorhexidine mouthwash with boric acid (1%)|PROCEDURE: Chlorhexidine mouthwash with boric acid (1.5%)|PROCEDURE: Chlorhexidine mouthwash with boric acid (2%)|PROCEDURE: Chlorhexidine mouthwash with boric acid (2.5%)|PROCEDURE: Boric acid mouthwash (2%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability and Pharmacokinetics of Multiple Doses of VAK694 in Atopic Subjects With Seasonal Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: VAK694|DRUG: Fluticasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Safety and Efficacy of Tafasitamab Plus Lenalidomide in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (firmMIND)
Status: RECRUITING
Conditions: Large B-Cell Lymphoma|Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Tafasitamab|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy of VLY-686 in Relieving Symptoms of Gastroparesis
Status: COMPLETED
Conditions: Gastroparesis
Interventions: DRUG: VLY-686 (Tradipitant)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vasosol Organ Perfusion Solution and Medtronic Portable Bypass System
Status: COMPLETED
Conditions: Liver Transplantation|Organ Preservation
Interventions: DEVICE: Vasosol Organ Perfusion Solution and Medtronic Portable Bypass System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Pharmacokinetics (PK) and Safety of Oral Mobocertinib in Participants With Moderate or Severe Hepatic Impairment (HI) and Normal Hepatic Function
Status: COMPLETED
Conditions: Hepatic Impairment|Healthy Volunteers
Interventions: DRUG: Mobocertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Randomized Controlled Trial of HER-2 Positive Breast Cancer Patients Treated With Lapatinib vs Herceptin
Status: UNKNOWN
Conditions: HER2-positive Breast Cancer
Interventions: DRUG: lapatinib/herceptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Baseline Performance and Fitting Parameters for Sonova Products
Status: ENROLLING_BY_INVITATION
Conditions: Hearing Loss|Ear Diseases|Hearing Disorders|Otolaryngological Disease
Interventions: DEVICE: Pinna-located microphone|DEVICE: Pinna-simulated microphone algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clevidipine for the Antihypertensive Treatment of Acute Intracerebral Hemorrhage
Status: NOT_YET_RECRUITING
Conditions: Intracerebral Hemorrhage|Stroke|Hypertension
Interventions: DRUG: Clevidipine Injection|DRUG: Alternate IV Antihypertensive Regimen
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Carbohydrate-restricted Diet to Reverse Fatty Liver in Adolescents With Obesity
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease|Childhood Obesity|Insulin Resistance
Interventions: OTHER: Carbohydrate-restricted diet|OTHER: Control, low-fat diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HLA-mismatched Microtransplantation Without Immunosuppressive Treatment in Patients With Myeloid Hemopathies
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: HLA-mismatched microtransplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ABLATE Versus PACE: PVI or AV Node Ablation and PM Implantation for Elderly Patients With Persistent AF
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Cryoballoon pulmonary-vein isolation|PROCEDURE: Pacemaker implantation and ablation of atrioventricular-node
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BF2.649 in Patients With OSA, Still Complaining of EDS and Refusing to be Treated by CPAP.
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Excessive Daytime Sleepiness
Interventions: DRUG: BF2.649|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Taiwan Health Promotion Intervention Study for Elders
Status: COMPLETED
Conditions: Frail Elderly Syndrome|Cognitive Impairment|Cognitive Decline
Interventions: BEHAVIORAL: Multidomain intervention|BEHAVIORAL: Active control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Drug-Drug Interaction Study of CTL0901 and CTL0902 Compared to Coadministration in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Health, Subjective
Interventions: DRUG: Drug: Treatment A|DRUG: Drug: Treatment B|DRUG: Drug: Treatment C
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blood Samples From Patients on a Clinical Trial to CINV During HSCT
Status: TERMINATED
Conditions: Breast Cancer|Chronic Myeloproliferative Disorders|Gestational Trophoblastic Tumor|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Nausea and Vomiting|Neuroblastoma|Ovarian Cancer|Testicular Germ Cell Tumor
Interventions: OTHER: immunoenzyme technique|OTHER: laboratory biomarker analysis|OTHER: medical chart review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hot Flashes and Neurovascular Function in Women
Status: RECRUITING
Conditions: Hot Flashes|Menopause|Vasomotor System; Labile
Interventions: OTHER: Sympathoexcitatory stressors|DRUG: Sodium Nitroprusside|DRUG: Acetylcholine|DRUG: Terbutaline|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Evaluate the Effect of Mirabegron (YM178) on Blood Levels of Desipramine When They Are Taken Together
Status: COMPLETED
Conditions: Pharmacokinetics of Mirabegron|Healthy Subjects
Interventions: DRUG: mirabegron|DRUG: desipramine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Study of Pembrolizumab and Cryoablation in People With Breast Cancer
Status: RECRUITING
Conditions: Metastatic Breast Cancer|Breast Cancer|Breast Cancer Stage IV|Triple Negative Breast Cancer|Triple Negative Breast Neoplasms|Metastatic Triple-Negative Breast Carcinoma|Locally Advanced Breast Cancer|Locally Advanced Triple-Negative Breast Carcinoma
Interventions: DRUG: Pembrolizumab|DEVICE: Cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PHA-739358 in Treating Patients With Chronic Myelogenous Leukemia That Relapsed After Imatinib Mesylate or c-ABL Therapy
Status: UNKNOWN
Conditions: Leukemia
Interventions: DRUG: danusertib|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurophysiological Markers in the Depressive Episode Characterized by Anhedonic Drug Resistance: Evaluation of Motor Skills and P300 Wave
Status: UNKNOWN
Conditions: Bipolar Anhedonic Depression
Interventions: BEHAVIORAL: Electroencephalogram|BEHAVIORAL: walking test|BEHAVIORAL: Quality of life questionnaire|PROCEDURE: Position emission tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Androgen Responses to hCG and Ovarian Morphology in PCOS
Status: UNKNOWN
Conditions: PCOS
Interventions: DRUG: MetFORMIN 500 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: ImmeDiate Versus EArLy Invasive Approach in Non-ST-Elevation Myocardial Infarction (IDEAL NSTEMI)
Status: WITHDRAWN
Conditions: Non-ST-elevation Myocardial Infarction
Interventions: PROCEDURE: immediate angiography and revascularization|PROCEDURE: early invasive angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Trial to Assess the Safety and Efficacy of Plant Cell Expressed GCD in Patients With Gaucher Disease
Status: COMPLETED
Conditions: Gaucher Disease
Interventions: DRUG: Plant cell expressed recombinant glucocerebrosidase (prGCD)|DRUG: Plant cell expressed recombinant glucocerebrosidase (prGCD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Unidirectional Face Mask During NPPV in COPD Patients
Status: WITHDRAWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: A unidirectional face mask (Modified 'Respironics PerformaTrak' Mask)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on Laparoscopic Gastrectomy for Early Gastric Cancer (COACT_0301)
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: PROCEDURE: laparoscopy assisted distal gastrectomy|PROCEDURE: Open distal gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In Utero Repair of Myelomeningocele: Atosiban Versus Terbutaline
Status: COMPLETED
Conditions: Myelomeningocele|Terbutaline Adverse Reaction|Pregnancy; Malformation Central Nervous System
Interventions: DRUG: Atosiban|DRUG: Terbutaline
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Single Ascending Dose Study of SAR439459 in Adults With Osteogenesis Imperfecta (OI)
Status: RECRUITING
Conditions: Osteogenesis Imperfecta
Interventions: DRUG: SAR439459|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study of the Avenue L Interbody Spinal Fusion System Using VerteBRIDGE Plating and Posterior Fixation
Status: TERMINATED
Conditions: Degenerative Disc Disease
Interventions: DEVICE: Avenue® L Interbody Fusion System (LDR Spine)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: StayFine: Personalised Relapse Prevention of Anxiety and Mood Disorders in Youths
Status: RECRUITING
Conditions: Depressive Disorder|Anxiety Disorders
Interventions: BEHAVIORAL: StayFine guided app-based personalised intervention modules|BEHAVIORAL: StayFine app-based monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Role of Neurogenic Inflammation and Topical 6% Gabapentin Therapy in Symptomatic Scarring Alopecia
Status: COMPLETED
Conditions: Scarring Alopecia|Frontal Fibrosing Alopecia|Lichen Planopilaris|Central Centrifugal Cicatricial Alopecia|Central Centrifugal Scarring Alopecia
Interventions: DRUG: Topical gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of the Safety and Efficacy of Nitazoxanide on Collagen Turnover in NASH Patients With Fibrosis
Status: COMPLETED
Conditions: Non-alcoholic Steatohepatitis|Fatty Liver|Fibrosis, Liver|Compensated Cirrhosis
Interventions: DRUG: Nitazoxanide 500mg BID
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of CC-5013 to Evaluate Safety, Pharmacokinetics and Effectiveness for Japanese Patients With Symptomatic Anemia Associated With Myelodysplastic Syndrome With a Del(5)(q31-33) Abnormality.
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of the Combination Estradiol and Progesterone to Treat Vasomotor Symptoms
Status: COMPLETED
Conditions: Menopause
Interventions: DRUG: Estradiol|DRUG: Progesterone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multicentric Point of Care UltraSound by Surgeons Trial
Status: COMPLETED
Conditions: Biliary Disease|Gallstone; Cholecystitis, Acute|Diverticulitis, Colonic|Abscess Pelvic
Interventions: DIAGNOSTIC_TEST: Point of Care Ultrasound by Surgeons (POCUSS)|DIAGNOSTIC_TEST: Radiology report|PROCEDURE: Surgery-Intra-operative findings
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Prophylactic Aqueous Suppression on Hyperencapsulation of Ahmed Glaucoma Valves
Status: UNKNOWN
Conditions: Glaucoma
Interventions: DRUG: Aqueous Suppressant Eye Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Detecting Abdominal Aortic Aneurysms in First Degree Relatives (Adult Offsprings) to AAA Patients (DAAAD)
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: DIAGNOSTIC_TEST: Ultrasound and questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pyridoxine Effect on the Blood Glucose Level in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Metformin 500 mg/day|COMBINATION_PRODUCT: Metformin 500 mg/day plus vitamin B6 300 mg/day|OTHER: non-pharmacological therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Psychosocial Intervention to Reduce Self-stigma and Improve Quality of Life Among People With Mental Illness in Chile
Status: COMPLETED
Conditions: Schizophrenia|Bipolar Disorder|Schizoaffective Disorder
Interventions: BEHAVIORAL: Intervention to reduce self-stigma among people with mental illness|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Novel Treatment For Chronic Posttraumatic Stress Disorder (PTSD) Using Post-Reactivation Propranolol
Status: UNKNOWN
Conditions: Stress Disorders, Post-Traumatic
Interventions: DRUG: Propranolol is available in generic form as the Wyeth product under the trade name Inderal.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bisphosphonates and Impaction Grafting in Hip Revision
Status: COMPLETED
Conditions: Aseptic Loosening of the Hip Prosthesis
Interventions: DRUG: Clodronate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: KONTAKT Australia a Social Skills Group Training for Adolescents on the Autism Spectrum
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: KONTAKT Australia|OTHER: Super Chef
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Adverse Events and Movement of Intravenously (IV) Infused ABBV-787 in Adult Participants With Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML)
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: ABBV-787
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of 6-Week Vibration and Non-Vibration Foam Rolling
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: Vibration Foam Rolling|OTHER: Non-Vibration Foam Rolling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of BMS-816336 in Healthy Male Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus, Non-Insulin-Dependent|Dyslipidemia
Interventions: DRUG: BMS-816336|DRUG: BMS-816336|DRUG: BMS-816336|DRUG: BMS-816336|DRUG: BMS-816336|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Comparison of Absorption of Vitamin K2
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Vitamin K2 in softgel|DIETARY_SUPPLEMENT: Vitamin K2 in Gelpell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Weekly Administration of Rifapentine and Isoniazid on Steady State Pharmacokinetics of Tenofovir Alafenamide in Healthy Volunteers (YODA)
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Tenofovir alafenamide|DRUG: Rifapentine|DRUG: Isoniazid (INH)|DIETARY_SUPPLEMENT: Pyridoxine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate Pharmacokinetic and Pharmacodynamic Drug Interactions and Safety of IY-HCR21 and IY-MIC
Status: ACTIVE_NOT_RECRUITING
Conditions: Pharmacokinetics
Interventions: DRUG: IY-HCR21|DRUG: IY-MIC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Light Stimulation to Improve Visual Function After Optic Neuritis in Persons With Multiple Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis, Relapsing-Remitting|Optic Neuritis
Interventions: DEVICE: Light stimulation|DEVICE: Sham light stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Choline Supplementation on Fetal Growth in Gestational Diabetes Mellitus
Status: RECRUITING
Conditions: Gestational Diabetes
Interventions: DIETARY_SUPPLEMENT: Choline supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Grape Seed Extract (GSE) on Insulin Resistance
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Grape Seed Extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Noninvasive Treatment of Upper Trapezius Active Trigger Points in College Students With Neck Pain
Status: COMPLETED
Conditions: Neck Pain|Trigger Point Pain, Myofascial
Interventions: OTHER: Jones Group (Strain Counterstrain)|OTHER: Lewit Group|OTHER: Chaitow Group|OTHER: Placebo Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating ImmuNe Changes in the Evolution of Pre Type 1 Diabetes With Adult ONset
Status: COMPLETED
Conditions: Type 1 Diabetes|Type 1 Diabetes Mellitus Maturity Onset
Interventions: GENETIC: High genetic risk for type 1 diabetes|GENETIC: High gentic risk for Coeliac disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Biodistribution of 1-L-(2 Deoxy-2,- 18 Fluoroarabinofuranosyl) Cytosine ([18F]L-FAC) in Healthy Subjects and Patients With Cancer, Autoimmune and Inflammatory Diseases
Status: COMPLETED
Conditions: Autoimmune Diseases|Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Second-Line Oxaliplatin and Irinotecan Versus Irinotecan Alone for Gemcitabine and S-1 Refractory Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Neoplasms
Interventions: DRUG: Irinotecan|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT