pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Clinical Trial to Study the Effects of Two Home Made Mouthwashes in Patients With Gum Diseases
Status: COMPLETED
Conditions: Gingivitis|Periodontitis
Interventions: PROCEDURE: HOT SALT WATER|PROCEDURE: POTASSIUM PERMANGANATE|PROCEDURE: CHLORHEXIDINE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Status: RECRUITING
Conditions: Coronavirus Infection (COVID-19)|Pulmonary Arterial Hypertension|Urinary Tract Infections in Children|Hypertension|Pain|Hyperphosphatemia|Primary Hyperaldosteronism|Edema|Hypokalemia|Heart Failure|Hemophilia|Menorrhagia|Insomnia|Pneumonia|Skin Infection|Arrythmia|Asthma in Children|Bronchopulmonary Dysplasia|Adrenal Insufficiency|Fibrinolysis; Hemorrhage|Attention Deficit Hyperactivity Disorder|Multisystem Inflammatory Syndrome in Children (MIS-C)|Kawasaki Disease|Coagulation Disorder|Down Syndrome
Interventions: DRUG: The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Alectinib Followed by Concomitant Consolidation Radiation Therapy in Advanced NSCLC With ALK-rearrangement (A-SAB)
Status: RECRUITING
Conditions: Radiotherapy Side Effect|Non-small Cell Lung Cancer|ALK Gene Mutation
Interventions: RADIATION: SBRT/SRS/radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of the SMART COPD Physical Activity App in Pulmonary Rehabilitation
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DEVICE: SMART COPD app to promote physical activity in COPD. Used in conjunction with a Fitbit Charge|DEVICE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Maternal Speech Decreases Pain Scores and Increases Oxytocin Levels in Preterm Infants During Painful Procedures
Status: COMPLETED
Conditions: Preterm Birth|Pain, Procedural
Interventions: BEHAVIORAL: Maternal speech|BEHAVIORAL: Maternal singing|BEHAVIORAL: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Application of UCPCR as a Testing Tool for Identification of MODY Patients in the UAE
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2|Maturity-onset Diabetes of the Young
Interventions: GENETIC: Next generation sequencing (NGS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Calcium Channel Blockers Compared to Magnesium Sulfate in Fetal Cerebral Blood Flow
Status: COMPLETED
Conditions: Preterm Labor|Cerebral Palsy
Interventions: DRUG: Magesium sulphate|DRUG: Nifedipine|RADIATION: Doppler on fetal middle cerebral artery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Efficacy and Safety of the Beta-3 Agonist Mirabegron (YM178) in Patients With Symptoms of Overactive Bladder
Status: COMPLETED
Conditions: Urinary Bladder, Overactive
Interventions: DRUG: Mirabegron|DRUG: Tolterodine|DRUG: Placebo to Mirabegron|DRUG: Placebo to Tolterodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-ocular Pressure and Ventilation
Status: COMPLETED
Conditions: Pneumoperitoneum
Interventions: PROCEDURE: HFJV ventilation|PROCEDURE: IPPV ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Gemcitabine and Vinorelbine in Treating Young Patients With Recurrent or Refractory Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|DRUG: gemcitabine hydrochloride|DRUG: vinorelbine tartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Efficiency For Brain Metastasis NSCLC Patients Treated With Icotinib Alone or Combined With Radiation Therapy
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer|Brain Metastases
Interventions: DRUG: Icotinib|RADIATION: SRS/WBRT/HA-WBRT/SMART
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fludarabine Phosphate, Rituximab, and Bevacizumab in Treating Patients With B-Cell Chronic Lymphocytic Leukemia That Has Relapsed or Not Responded To Treatment
Status: WITHDRAWN
Conditions: B-cell Chronic Lymphocytic Leukemia|Refractory Chronic Lymphocytic Leukemia
Interventions: DRUG: fludarabine phosphate|BIOLOGICAL: rituximab|BIOLOGICAL: bevacizumab|OTHER: laboratory biomarker analysis|OTHER: flow cytometry|GENETIC: polymerase chain reaction|GENETIC: fluorescence in situ hybridization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of DFD-06 Cream in the Treatment of Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: DFD06 Cream|DRUG: Vehicle Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Web- Based Cognitive Behavioral Therapy for Depressed Korean Adolescents
Status: UNKNOWN
Conditions: Depression|Mental Disorder in Adolescence|Cognitive Behavioral Therapy
Interventions: BEHAVIORAL: web-based CBT|BEHAVIORAL: supportive care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Fecal Microbiota Transplantation (FMT) in the Treatment of Ulcerative Colitis
Status: RECRUITING
Conditions: Active Ulcerative Colitis (UC)
Interventions: DRUG: PRIM-DJ2727 - FROZEN|DRUG: PRIM-DJ2727 - CAPSULES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-Inferiority of Meningococcal Vaccine GSK134612 Versus Mencevax™ in 2-10 Year Old Subjects
Status: COMPLETED
Conditions: Infections, Meningococcal|Meningococcal Vaccines
Interventions: BIOLOGICAL: Nimenrix|BIOLOGICAL: Mencevax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: BPM31510 Administered Intravenously With Gemcitabine in Advanced Pancreatic Cancer Patients
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: BPM31510 Nanosuspension Injection|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetic Ablation of CD33 in HSC to Broaden the Therapeutic Index of CD33-directed Immunotherapy in Patients With AML
Status: NOT_YET_RECRUITING
Conditions: Relapsed/Refractory Acute Myeloid Leukemia (AML)
Interventions: BIOLOGICAL: Donor-derived CD34+ HSC with CRISPR/Cas9-mediated CD33 deletion|DRUG: Gemtuzumab Ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sufentanil NanoTab PCA System/15 mcg for Acute Post-Operative Pain in Vertebral Surgery: A Preliminary Investigation
Status: COMPLETED
Conditions: Postoperative Pain|Spinal Fusion|Spondylolisthesis, Lumbar Region|Sufentanil
Interventions: COMBINATION_PRODUCT: Sufentanil NanoTab PCA System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Effect of Letrozole and Tamoxifen on Bone and Lipids in Postmenopausal Women With Breast Cancer
Status: COMPLETED
Conditions: Hormone Sensitive Resected Primary Breast Cancer in Postmenopausal Women
Interventions: DRUG: Letrozole|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sham Anti-inflammatory Diet on Inflammation After Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury|Inflammation
Interventions: OTHER: Placebo Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fusion Versus Cognitive MRI Targeted Prostatic Biopsy
Status: RECRUITING
Conditions: Prostatic Cancer
Interventions: PROCEDURE: MRI fusion targeted prostatic biopsy|PROCEDURE: MRI cognitive targeted prostatic biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of the Safety and Efficacy of Bimatoprost in Patients With Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: bimatoprost eye drops|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Jobelyn (Sorghum Bicolor Extract)in the Treatment of Sickle Cell Anemia
Status: COMPLETED
Conditions: Sickle Cell Anemia
Interventions: DRUG: Paludrine + Folic Acid|DIETARY_SUPPLEMENT: Paludrine + Folic Acid + Jobelyn
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of Onartuzumab (MetMAb) Versus Placebo in Combination With Paclitaxel Plus Platinum in Patients With Squamous Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: Placebo|DRUG: cisplatin/carboplatin|DRUG: onartuzumab|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CSD190501: A Study to Determine Subject Puffing Patterns of an Electronic Nicotine Delivery System in an Ambulatory Setting
Status: COMPLETED
Conditions: Smoking|Smoking Behaviors|Tobacco Use|Tobacco Smoking
Interventions: OTHER: CSD1905-11|OTHER: CSD1905-12|OTHER: CSD1905-13|OTHER: CSD1905-14|OTHER: CSD1905-15|OTHER: CSD1905-16|OTHER: CSD1905-17
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Anlotinib Plus Irinotecan in Patients With Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Anlotinib Plus Irinotecan|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study to Evaluate Allogeneic HSCT Outcomes for Cerebral Adrenoleukodystrophy (CALD)
Status: TERMINATED
Conditions: X-Linked Adrenoleukodystrophy (X-ALD)|Cerebral Adrenoleukodystrophy (CALD)|Adrenoleukodystrophy (ALD)
Interventions: GENETIC: Allo-HSCT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: OPTImized Restrictive Strategy Targeting Non-Resuscitative FLUIDs in Septic Shock: Pilot Study.
Status: COMPLETED
Conditions: Septic Shock|Electrolyte and Fluid Balance Conditions
Interventions: OTHER: Reduction of the patient's fluid intake during the first 7 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Subconjunctival Aflibercept (EYLEA®) for the Treatment of Corneal Neovascularization
Status: TERMINATED
Conditions: Corneal Neovascularization
Interventions: DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Noninvasive Techniques to Study Neutrophil Airway Inflammation in an Ozone Challenge Model
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: OTHER: ozoneexposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety of a Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine in Healthy Subjects in Vietnam
Status: COMPLETED
Conditions: Meningitis|Meningococcal Meningitis|Meningococcal Infections
Interventions: BIOLOGICAL: Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine|BIOLOGICAL: Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase IV Clinical Trial to Investigate the Effect on Blood Glucose of Evogliptin in Patients With Type 2 Diabetes(EVERGREEN)
Status: COMPLETED
Conditions: Type2 Diabetes
Interventions: DRUG: evogliptin|DRUG: Linagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicountry Studies on the Effect of Positional Distribution of Fatty Acids at Triglyceride Backbone on Serum Lipids, Lipoprotein(a) and LDL-subclasses in Healthy Malaysian Volunteers
Status: COMPLETED
Conditions: Cardiovascular Risk Factor
Interventions: OTHER: Diet: Palm olein IV64|OTHER: Diet: Cocoa butter|OTHER: Diet: Virgin olive oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: High Flow Nasal Cannula Versus Non-invasive Ventilation in Prevention of Escalation to Invasive Mechanical Ventilation in Patients With Acute Hypoxemic Respiratory Failure
Status: UNKNOWN
Conditions: Respiratory Failure
Interventions: DEVICE: non-invasive ventilation|DEVICE: high flow nasal cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "Psychological Intervention Enhanced by Virtual Reality for the Improvement of Appreciation of Body Functionality in Patients With Chronic Low-back-pain".
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Low-back Pain
Interventions: DEVICE: CLEVER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Peer Leaders as HIV Risk Reduction Change Agents Among Injection Drug Users (IDUs) in Ukraine
Status: COMPLETED
Conditions: HIV Infection|HIV Risk Behaviors
Interventions: BEHAVIORAL: Peer Education Model|BEHAVIORAL: HIV Counseling and Education Model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Hyaluronidase in Treating Oral Microstomia in Patients With Sclerosing Skin Disease
Status: WITHDRAWN
Conditions: Microstomia|Scleroderma|CREST Syndrome|Scleromyxedema|Morphea
Interventions: DRUG: hyaluronidase injected intradermally
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Standard Dose Versus High-Dose Inactivated Flu Vaccine in Pediatric Solid Organ Transplant Patients
Status: COMPLETED
Conditions: Pediatric Solid Organ Transplant Patients
Interventions: DRUG: High-Dose trivalent inactivated influenza vaccine|DRUG: Standard dose trivalent inactivated influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Effect of add-on Pioglitazone or Dapagliflozin in Participants With Type 2 Diabetes Mellitus Inadequately Controlled by DPP-4 Inhibitor and Metformin Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Pioglitazone + Alogliptin|DRUG: Alogliptin|DRUG: Metformin|DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of BAY86-5300 With a Flexible Extended Regimen for Dysmenorrhea
Status: COMPLETED
Conditions: Dysmenorrhea
Interventions: DRUG: EE20/DRSP(BAY86-5300)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Anesthesia With Minimal Sedation and Brachial Plexus Block in Hand Surgery
Status: COMPLETED
Conditions: Hand Surgery|Quality of Recovery|Hand Injuries|Hand Fracture|Hand Tendon Injury|Anesthesia, Local
Interventions: PROCEDURE: Local anesthesia with minimal sedation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: To Compare Efficacy and Safety Between CT-P10 and Rituxan in Patients With Low Tumour Burden Follicular Lymphoma
Status: COMPLETED
Conditions: Follicular Lymphoma
Interventions: BIOLOGICAL: CT-P10|BIOLOGICAL: Rituxan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation Study Between Density Gradient and Swimming Down for Semen Processing
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: Diff-Quik staining for morphology evaluation|PROCEDURE: Motility Evaluation for grade A and B|PROCEDURE: Concentration (mil/ml)|PROCEDURE: 24 H half life|PROCEDURE: 48 H half life|PROCEDURE: HBA Testing|BIOLOGICAL: Bacterial contamination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preoperative Prehabilitation for Sarcopenic Patients Prior to Pancreatic Surgery for Cancer
Status: RECRUITING
Conditions: Sarcopenia|Pancreatic Cancer
Interventions: OTHER: Prehabilitation program|DIETARY_SUPPLEMENT: Oral Impact
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Interleukin-12 Plus Interleukin-2 in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: recombinant interleukin-12|BIOLOGICAL: aldesleukin|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Pharmacodynamics and Safety of DEB025 Plus Ribavirin in Chronic Hepatitis C Genotype 2 and 3 Treatment naïve Patients
Status: COMPLETED
Conditions: Hepatitis C|Liver Disease
Interventions: DRUG: Alisporivir|DRUG: Ribavirin|DRUG: Peg-IFNα2a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of PWI Assisted by Marshall Ethanolization in Ablation of Persistent Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: VOMEI + PVI + linear ablation of mitral isthmus|PROCEDURE: Posterior wall isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study of 2 Doses of BM Autologous H-MSC+Biomaterial vs Iliac Crest AutoGraft for Bone Healing in Non-Union
Status: UNKNOWN
Conditions: Non Union Fracture
Interventions: BIOLOGICAL: Cultured Mesenchymal Stem Cells|PROCEDURE: Autologous iliac crest graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supporting Treatment Outcomes Among PWID
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatitis C|HIV Coinfection
Interventions: BEHAVIORAL: Low intensity HCV treatment adherence support|BEHAVIORAL: Medium intensity HCV treatment adherence support|BEHAVIORAL: High intensity HCV treatment adherence support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Pain Rate of Single Versus Two-visit Root Canal Treatment of Teeth With Necrotic Pulps
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: PROCEDURE: Ibuprofen for post operative pain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety Study of Electro-acupuncture for Severe Chronic Functional Constipation
Status: COMPLETED
Conditions: Constipation
Interventions: DEVICE: electro-acupuncture|DEVICE: sham electro-acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Cortical Motor Effects of PNS and AO on Motor Training in Chronic Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: GENETIC: PNS+AO+Training|GENETIC: PNS+AOsham+Training|GENETIC: PNSsham+AOsham+Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study to Compare the Blood Levels of Abatacept Manufactured at Lonza Biologics to the Blood Levels of Abatacept Manufactured at the Devens, Massachusetts (MA) Facility of Bristol-Myers Squibb
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Abatacept (BMS-188667)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Safety and Preliminary Efficacy of JBH492 Monotherapy in Patients With CLL and NHL
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Hodgkins Lymphoma|Chronic Lymphocytic Leukemia
Interventions: DRUG: JBH492
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare Efficacy of CHOP Versus Fractionated ICED in Transplant-eligible Patients With Previously Untreated PTCL
Status: UNKNOWN
Conditions: Peripheral T-cell Lymphoma
Interventions: DRUG: CHOP|DRUG: fractionated ICED
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HemosprayTM for Gastrointestinal Bleeding From Cancer
Status: UNKNOWN
Conditions: Gastrointestinal Bleeding From Malignancy
Interventions: DEVICE: TC-325
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Surgical Weight Loss to Treat Obstructive Sleep Apnea
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea|Obesity
Interventions: PROCEDURE: Bariatric surgery|DEVICE: Continuous positive airway pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 7 Days of TD-4208 in Subjects With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: TD-4208|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Survival of Patients With Acute Heart Failure in Need of Intravenous Inotropic Support: a Multicentre, Parallel-Group, Randomised, Double-Blind, Double-Dummy Study of Levosimendan Versus Dobutamine in Patients With Acute Heart Failure.
Status: COMPLETED
Conditions: Acute Heart Failure
Interventions: DRUG: levosimendan|DRUG: dobutamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Prospective Clinical Trials on Skin Wound Healing in Young and Aged Individuals
Status: COMPLETED
Conditions: Age|Cicatrix, Hypertrophic|Fibrosis|Diabetes Mellitus
Interventions: OTHER: Skin sample|OTHER: Skin biopsy|OTHER: Skin biopsy|OTHER: Blood taking|OTHER: Blood taking
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate Absolute Bioavailability, Absorption, Metabolism, and Excretion of Genz-112638 in Healthy Male Participants
Status: COMPLETED
Conditions: Gaucher's Disease Type I
Interventions: DRUG: Genz-112638|DRUG: Genz-112638|DRUG: [14C]-Genz-112638
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Haploidentical Transplant for People With Chronic Granulomatous Disease Using Post Transplant Cyclophosphamide
Status: TERMINATED
Conditions: Chronic Granulomatous Disease
Interventions: DRUG: Sirolimus|BIOLOGICAL: Donor peripheral blood stem cells.|DRUG: Cyclophosphamide post transplant|RADIATION: Total body 200cGy|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Busulfan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antimicrobial Stewardship Program (ASP) in Patients With a Sore Throat
Status: COMPLETED
Conditions: Tonsillitis|Streptococcus Pharyngitis|Sore Throat|Pharyngitis|Pharyngitis Bacterial
Interventions: OTHER: ASP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Antibiotics for Severe Perineal Laceration to Prevent Infection Following Repair
Status: RECRUITING
Conditions: Vaginal Laceration During Delivery
Interventions: DRUG: Augmentin/Flagyl or Augmentin/Clindamycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Nonstress Test Device Noise Level on Stress Parameters in Primiparous Pregnant Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Stress|Noise Exposure|Prenatal Stress|Prenatal Care Late|Pregnancy Related
Interventions: DIAGNOSTIC_TEST: Stress Parameters Measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Metabolic Effect of New Foods Through Gut-brain Axis
Status: COMPLETED
Conditions: Obesity|Overweight
Interventions: DIETARY_SUPPLEMENT: Satiety of breads|DIETARY_SUPPLEMENT: Satiety of puddings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Technology, Exercise Programming, and Activity Prescription for Enhanced Mobility (TEAM) Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteo Arthritis Knee|Osteoarthritis|Hip Arthritis
Interventions: DEVICE: PAARx|DEVICE: JM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IRDye800CW-BBN PET-NIRF Imaging Guiding Surgery in Patients With Glioblastoma
Status: UNKNOWN
Conditions: Glioblastoma
Interventions: DRUG: 68Ga-BBN-IRDye800CW|DEVICE: PET/NIRF|PROCEDURE: PET/NIR fluorescent imaging-guided surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Preventive Treatment for Migrant Workers at High-risk of COVID-19
Status: COMPLETED
Conditions: Covid-19
Interventions: DRUG: Hydroxychloroquine Sulfate Tablets|DRUG: Ivermectin 3mg Tab|DRUG: Zinc|DRUG: Povidone-Iodine|DIETARY_SUPPLEMENT: Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Tanezumab in Osteoarthritis of the Hip or Knee (2)
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: BIOLOGICAL: tanezumab 10 mg|BIOLOGICAL: tanezumab 5 mg|DRUG: naproxen|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Fatty Acids and Postoperative Complications After Colorectal Surgery
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: supportan|DIETARY_SUPPLEMENT: supportan placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Ultrasound Guided Transfemoral Complex Large-bore PCI Trial
Status: COMPLETED
Conditions: Complex Coronary Lesions|Percutaneous Coronary Intervention
Interventions: PROCEDURE: Ultrasound guided femoral access for complex PCI|PROCEDURE: Fluoroscopy guided femoral access for complex PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Use of Magnesium Sulfate for Prevention of Postspinal Shivering
Status: COMPLETED
Conditions: Prevention of Postspinal Shivering
Interventions: DRUG: Magnesium Sulfate 1000 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy, Safety and Tolerability of NVA237 in Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: NVA237|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Clofarabine in Patients With Recurrent or Refractory Langerhans Cell Histiocytosis and LCH-related Disorders
Status: ACTIVE_NOT_RECRUITING
Conditions: Langerhans Cell Histiocytosis
Interventions: DRUG: Clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Tumor Lysate Vaccine and Iscomatrix With or Without Metronomic Oral Cyclophosphamide and Celecoxib in Patients With Malignancies Involving Lungs, Esophagus, Pleura, or Mediastinum
Status: TERMINATED
Conditions: Thoracic Sarcomas|Thorasic Cancers|Cancers of Non-thoracic Origin With Metastases to the Lungs or Pleura|Sarcoma|Melanoma
Interventions: BIOLOGICAL: H1299 cell lysates|DRUG: Cyclophosphamide|DRUG: Celecoxib|BIOLOGICAL: Iscomatrix adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Food Effect on the Bioavailability of 4-MUST, Tablets, 128 mg
Status: RECRUITING
Conditions: Cholecystitis
Interventions: DRUG: 4-MUST, 2 tablets, fasted|DRUG: 4-MUST, 2 tablets, after meals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Echo-Doppler Assessment of the Occurrence of Asymptomatic DVT in Orthopedic Replacement Surgery Under Enoxaparin
Status: COMPLETED
Conditions: Deep Vein Thrombosis|Venous Thrombosis|Adverse Effect of Anticoagulants
Interventions: DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fasting Mimicking Diet in Chemotherapy of Gynecologic Malignancies
Status: RECRUITING
Conditions: Cancer, Ovarian|Chemotherapy Effect|Calorie Deficiency|Fasting, Intermittent
Interventions: OTHER: Fasting Mimicking Diet|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Oral Glucose Tolerance Test and Post Partum Diagnosis of Diabetes Mellitus, Type 2 (DT2 Post-Partum)
Status: COMPLETED
Conditions: Gestational Diabetes
Interventions: OTHER: frequency of diabetes mellitus, type 2, diagnosis in patients with medical history of gestational diabetes.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pregabalin Reduce the Sevoflurane Requirement
Status: COMPLETED
Conditions: Elective Laparoscopic Cholecystectomy|Sevoflurane Anesthesia
Interventions: DRUG: Placebo|DRUG: pregabalin|DRUG: pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Trial Evaluating the Effect of Tropisetron on Postoperative Cognitive Dysfunction After Cardiac Surgery
Status: UNKNOWN
Conditions: Postoperative Cognitive Dysfunction|Postoperative Delirium
Interventions: DRUG: Tropisetron|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Upper Sequential Distalization With TADs and Aligners
Status: UNKNOWN
Conditions: Malocclusion, Angle Class II|Distalization
Interventions: DEVICE: Orthodontic treatment with Invisalign system|DEVICE: Orthodontic treatment with Spark system|DEVICE: Orthodontic treatment with Quicksmile system|DEVICE: Orthodontic treatment with ClearCorrect system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Cardioprotective Effect of L-carnitine and Silymarin in Patients Receiving Anthracycline Chemotherapy
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: L-Carnitine 500Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Dry Needling & Trigger Point Compression Release in Neck Pain
Status: COMPLETED
Conditions: Neck Pain|Trigger Point Pain, Myofascial|Neck Muscle Issue|Muscle Tightness|Neckache
Interventions: OTHER: Dry Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of Transcranial Direct Current Stimulation Intensity on Leg Muscle Fatigability in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Sham transcranial direct current stimulation|DEVICE: Transcranial direct current stimulation at 2 mA|DEVICE: Transcranial direct current stimulation at 4 mA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-articular PVA Hydrogel in Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: PVA Hydrogel|DEVICE: Synvisk-One®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stabilizing Mood and Sleep With Blue Blocking Eyewear in Bipolar Disorder
Status: RECRUITING
Conditions: Bipolar Disorder
Interventions: DEVICE: Blue blocking eyewear|DEVICE: Low filtration eyewear
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cancer, Obesity/Overweight and Insomnia Study
Status: COMPLETED
Conditions: Breast Cancer|Overweight and Obesity|Insomnia
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia|BEHAVIORAL: Sleep Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Reduction of Obesity-Associated Intestinal Inflammation by Low-Fat Dairy Yogurt
Status: COMPLETED
Conditions: Intestinal Barrier Function|Chronic Inflammation
Interventions: OTHER: Low fat dairy yogurt|OTHER: Soy pudding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pneumococcal Conjugate Vaccine Followup
Status: COMPLETED
Conditions: Immune Tolerance
Interventions: BIOLOGICAL: Prevenar + PPV|BIOLOGICAL: Infant PCV (Prevenar) + PPV at 9 months|BIOLOGICAL: No Prevenar + PPV at 9 months|BIOLOGICAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Transvaginal Sonographic Measurement of Cervical Length Versus Bishop Score in Induction of Labour for Prediction of Caesarean Delivery.
Status: COMPLETED
Conditions: Failed Induction|Cervical Dystocia
Interventions: OTHER: Bishop score calculation of modified Bishop score in numbers by digital vaginal examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Pioglitazone on Myocardial Function in Patients Undergoing Coronary Stent Implantation.
Status: COMPLETED
Conditions: Oxidative Stress|Coronary Artery Disease|Type 2 Diabetes
Interventions: DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity, Reactogenicity and Safety Study of Two Different Formulations of GSK Biologicals' Human Rotavirus Vaccine, Rotarix, in Healthy Infants
Status: COMPLETED
Conditions: Rotavirus
Interventions: BIOLOGICAL: HRV Liquid|BIOLOGICAL: HRV Lyophilized
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Accountability for Care Through Undoing Racism & Equity for Moms
Status: RECRUITING
Conditions: Pregnancy Related|Maternal Health|Maternal Mortality|Low Birthweight|Racism|Implicit Bias
Interventions: OTHER: Data Accountability and Transparency|OTHER: Community-Based Doula (CBD) Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: This Study Looks at the Effects of Idarucizumab in Patients Who Take Dabigatran and Need Emergency Surgery or Are Bleeding
Status: COMPLETED
Conditions: Hemorrhage
Interventions: DRUG: Idarucizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ribociclib and Spartalizumab in R/M HNSCC
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Ribociclib|DRUG: Spartalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Factors Predicting Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma (HCC)
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Liver Cirrhosis|Evidence of Liver Transplantation
Interventions: OTHER: search of factors predicting tumor recurrence
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Predictors of Upper Airway Function and Sleep-disordered Breathing in the Critically Ill
Status: UNKNOWN
Conditions: Critically Ill|Obstructive Sleep Apnea
Interventions: DEVICE: Ventilator|DEVICE: Alice PDx|OTHER: Pulmonary function test|OTHER: Muscle strength tests|OTHER: Grip strength measurement|DRUG: Sedatives and muscle relaxants given in the ICU
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Abdominal Aortic Aneurysm Growth in Adult Smoking Patients Who Either Switch to IQOS, Continue Smoking, or Quit Smoking.
Status: COMPLETED
Conditions: Smoking|Abdominal Aortic Aneurysm|IQOS Use
Interventions: OTHER: IQOS|OTHER: Cigarette|OTHER: Smoking Cessation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison Between the Efficacy of SGLT2 Inhibitor Therapy Versus ACE Inhibitor in the Treatment of Diabetic Kidney Disease
Status: UNKNOWN
Conditions: Diabetic Nephropathy Type 2
Interventions: DRUG: Empagliflozin 25 MG|DRUG: Enalapril Maleate 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Study of MabThera/Rituxan (Rituximab) in Combination With Fludarabine And Cyclophosphamide as Primary Therapy in Elderly Patients With Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Lymphocytic Leukemia, Chronic
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Brensocatib Tablets in Adults With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Brensocatib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Foley Catheter Removal After Diverticular Colovesical Fistula Repair
Status: RECRUITING
Conditions: Colovesical Fistula
Interventions: PROCEDURE: Removal of Foley Catheter 2 to 3 days post Colovesical Fistula (CVF) repair surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of PEGylated Recombinant Human Hyaluronidase in Combination With Nab-Paclitaxel Plus Gemcitabine Compared With Placebo Plus Nab-Paclitaxel and Gemcitabine in Participants With Hyaluronan-High Stage IV Previously Untreated Pancreatic Ductal Adenocarcinoma
Status: TERMINATED
Conditions: Pancreatic Ductal Carcinoma
Interventions: OTHER: Biological: PEGylated Recombinant Human Hyaluronidase (PEGPH20)|DRUG: Placebo|DRUG: nab-Paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effective Study of Live Attenuated Varicella Vaccine to Treat Severe Resistant Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: live attenuated chicken pox vaccine|DRUG: saline, efficacy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A WeChat-based Intervention to Support Breastfeeding
Status: UNKNOWN
Conditions: Exclusive Breastfeeding
Interventions: OTHER: Breastfeeding related information delivered by WeChat|OTHER: Non-breastfeeding related information delivered by WeChat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase III Study to Evaluate the Efficacy and Safety of Benralizumab in Patients With Hypereosinophilic Syndrome (HES)
Status: RECRUITING
Conditions: Hypereosinophilic Syndrome
Interventions: BIOLOGICAL: Benralizumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perampanel for the Reduction of Seizure Frequency in Patients With High-grade Glioma and Focal Epilepsy
Status: TERMINATED
Conditions: Intractable Epilepsy|Malignant Glioma|Seizure Disorder|WHO Grade 2 Glioma|WHO Grade 3 Glioma
Interventions: DRUG: Anticonvulsant Agent|DRUG: Perampanel|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Restore Calcium Alginate Dressing, Silver vs Aquacel Ag in the Treatment of Critically Colonized Venous Leg Ulcers
Status: TERMINATED
Conditions: Venous Ulcer|Infection
Interventions: DEVICE: Restore Calcium Alginate Dressing|DEVICE: AquaCel Ag Wound Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 12-month, Phase 3, Open-label, Multi-center Study to Evaluate the Long-term Safety of PN400 (VIMOVO)
Status: COMPLETED
Conditions: Gastric Ulcer
Interventions: DRUG: PN400 (VIMOVO)|DRUG: PN 400 (VIMOVO)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Allowance of Methyl Donor Nutrients to Minimize Risks of Non-alcoholic Fatty Liver Progression
Status: UNKNOWN
Conditions: Non-alcoholic Fatty Liver Disease
Interventions: DIETARY_SUPPLEMENT: Folic acid, choline chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Ezetimibe Plus Atorvastatin Versus Atorvastatin Alone in Subjects With Primary Hypercholesterolemia (Study P03406)
Status: COMPLETED
Conditions: Hypercholesterolemia|Atherosclerosis
Interventions: DRUG: Ezetimibe|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Into LDN and NAD+ for Treatment of Patients With Post-COVID-19 Syndrome
Status: COMPLETED
Conditions: Covid19|Long COVID-19|Post-COVID-19 Syndrome
Interventions: DRUG: Naltrexone|DIETARY_SUPPLEMENT: NAD+
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT