pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: COLOR III Trial: Transanal vs Laparoscopic TME
Status: ENROLLING_BY_INVITATION
Conditions: Rectal Carcinoma|Surgery
Interventions: PROCEDURE: Laparoscopic TME|PROCEDURE: TaTME
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Midodrine Hydrochloride in Early Sepsis
Status: COMPLETED
Conditions: Sepsis|Blood Pressure
Interventions: DRUG: Midodrine Hydrochloride 10 milligrams|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Post-operative Pain in Colon Resections
Status: UNKNOWN
Conditions: Analgesia
Interventions: DEVICE: Sublingual sufentanil tablet system|DEVICE: Peridural catheter|DRUG: PCA Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation on the Role of Gut-liver Axis for Non-alcoholic Steatohepatitis Through Bariatric Surgery
Status: UNKNOWN
Conditions: Non-Alcoholic Fatty Liver Disease|Non-Alcoholic Steatohepatitis|Bariatric Surgery
Interventions: PROCEDURE: Bariatric surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PRCT001 Aquablation theraPy Outcomes in pRostate Cancer patienTs
Status: RECRUITING
Conditions: Benign Prostatic Hyperplasia|Localized Prostate Cancer
Interventions: DEVICE: Robotic Waterjet Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Refractory Meibomian Gland Dysfunction and Plasma Jet
Status: UNKNOWN
Conditions: Meibomian Gland Dysfunction|Dry Eye Disease|Evaporative Dry Eye|Inflammation|Tear Film Deficiency
Interventions: DEVICE: Jett Plasma Medical Lift|PROCEDURE: Mechanical Debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, First-In-Human Study of the Investigational COVID-19 Vaccine SC-Ad6-1 in Healthy Volunteers
Status: RECRUITING
Conditions: Covid19
Interventions: BIOLOGICAL: SC-Ad6-1|BIOLOGICAL: SC-Ad6-1|BIOLOGICAL: SC-Ad6-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Feasibility of Argatroban as Anticoagulant in Adults With ECMO
Status: RECRUITING
Conditions: Extracorporeal Membrane Oxygenation Complication|Anticoagulants and Bleeding Disorders
Interventions: DRUG: Argatroban|DRUG: Unfractionated heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ARC1779 Injection in Patients With Von Willebrand Factor-Related Platelet Function Disorders
Status: COMPLETED
Conditions: Purpura, Thrombotic Thrombocytopenic|Von Willebrand Disease Type-2b
Interventions: DRUG: ARC1779|DRUG: ARC1779|DRUG: ARC1779|DRUG: ARC1779|DRUG: ARC1779
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Intravenously Administered SNS-032 in Patients With Advanced B-lymphoid Malignancies
Status: COMPLETED
Conditions: B-lymphoid Malignancies|Chronic Lymphocytic Leukemia|Mantle Cell Lymphoma|Multiple Myeloma
Interventions: DRUG: SNS-032 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prosthetic Femoral Access for Haemodialysis
Status: UNKNOWN
Conditions: Vascular Access Complication
Interventions: PROCEDURE: Tunneled Femoral Catheter (TFC) group|PROCEDURE: Femoro-femoral Arteriovenous graft (FF-AVG) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Open-Label Study of Latanoprost Acid Plasma Concentrations in Pediatric and Adult Glaucoma Patients Treated With Latanoprost.
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: latanoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bipap Automatic Servo Ventilation (autoSV) Advanced in Central Apnea Patients
Status: COMPLETED
Conditions: Cheyne-Stokes Respiration|Sleep Apnea, Central
Interventions: DEVICE: BiPAP autoSV Advanced
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thermotherapy Against Persistent Bacterial LUNG Infections
Status: RECRUITING
Conditions: Lung Diseases, Obstructive|Bronchiectasis|Asthma|Copd|Chronic Obstructive Pulmonary Disease|Chronic Lung Infections
Interventions: OTHER: Thermotherapy/sauna bath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Safety and Clinical Efficacy of Ergoferon in Liquid Dosage Form in Treatment of Acute Upper Respiratory Tract Infections in Children
Status: COMPLETED
Conditions: Acute Upper Respiratory Tract Infections
Interventions: DRUG: Ergoferon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Study Comparing Genz-644470, Placebo, and Sevelamer Carbonate in Chronic Kidney Disease Patients on Hemodialysis
Status: COMPLETED
Conditions: Kidney Failure, Chronic
Interventions: DRUG: Placebo|DRUG: Genz-644470|DRUG: Sevelamer carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PERIODONTITIS AND VASCULAR DYSFUNCTION
Status: COMPLETED
Conditions: Periodontitis|Intimal Medial Thickness of Internal Carotid Artery
Interventions: PROCEDURE: Intensive Periodontal Treatment|PROCEDURE: Control Periodontal Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interactions Between Rifapentine and Dolutegravir in HIV/LTBI Co-Infected Individuals
Status: SUSPENDED
Conditions: HIV Infection|LTBI
Interventions: DRUG: Dolutegravir (DTG)|DRUG: Isoniazid (INH)|DRUG: Rifapentine (RPT)|DRUG: Antiretroviral Therapy (ART)|DIETARY_SUPPLEMENT: Pyridoxine (Vitamin B6)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaniprevir Administered With Pegylated-interferon and Ribavirin in Japanese Treatment-Naïve Chronic Hepatitis C Participants (MK-7009-043)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: vaniprevir|DRUG: Placebo to vaniprevir|BIOLOGICAL: Peg-IFN|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GT201 Injection in Combination With Teraplizumab Injection for Treatment of Patients With Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Adult|Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: GT201 injection in combination with teraplizumab injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pazopanib Hydrochloride in Treating Patients With Stage IV or Recurrent Nasopharyngeal Cancer
Status: COMPLETED
Conditions: Recurrent Lymphoepithelioma of the Nasopharynx|Recurrent Squamous Cell Carcinoma of the Nasopharynx|Stage IV Lymphoepithelioma of the Nasopharynx|Stage IV Squamous Cell Carcinoma of the Nasopharynx
Interventions: DRUG: pazopanib hydrochloride|OTHER: pharmacological study|PROCEDURE: computed tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Add on to Azythromycine, Phytomedicine and/or Antimalarial Drug vs Hydroxychloroquine in Uncomplicated COVID-19 Patients
Status: UNKNOWN
Conditions: Covid19
Interventions: COMBINATION_PRODUCT: Hydroxycloroquine and Azythromycine|COMBINATION_PRODUCT: Cospherunate/Azythromycine|COMBINATION_PRODUCT: Cospherunate/Phytomedicine/Azythromycien
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity Evaluation of Omicron Variant-based Vaccine and a Trivalent Vaccine in Adults Against COVID-19 in Chile
Status: COMPLETED
Conditions: COVID-19|Vaccines
Interventions: BIOLOGICAL: CoronaVac®|BIOLOGICAL: Omicron Vaccine|BIOLOGICAL: Trivalent Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The PIVOT Trial: Project on EHR-Integrated Lifestyle Interventions for Adults Aged Fifty and Older
Status: RECRUITING
Conditions: CARDIOMETABOLIC CONDITIONS|Obesity|Pre-diabetes|Metabolic Syndrome|Type2diabetes|Hypertension|Dyslipidemias
Interventions: BEHAVIORAL: Base intervention|BEHAVIORAL: Augmented Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low Level Light Device as a Primary Therapy for Androgenetic Alopecia
Status: UNKNOWN
Conditions: Androgenetic Alopecia|Hair Loss|Thinning Hair|Balding
Interventions: DEVICE: Genix|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Hypothermia for Intracerebral Hemorrhage in Croatia
Status: UNKNOWN
Conditions: Hypothermia|Primary Intracerebral Hemorrhage|Signs and Symptoms
Interventions: DEVICE: Cincinnati Sub-Zero," Blanketrol III"
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention to Address Disparate Mental Health Consequences of COVID-19 Pandemic on Latinx and African Newcomers
Status: ACTIVE_NOT_RECRUITING
Conditions: Mental Health Issue|Mental Health Disorder|Stress, Emotional|Economic Problems
Interventions: BEHAVIORAL: Refugee and Immigrant Well-being Project (RIWP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Liraglutide on Glucagon Secretion in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Horner's Syndrome Developing After Interscalene Brachial Plexus Block on Autonomic Nervous Activity
Status: COMPLETED
Conditions: Brachial Plexus Block|Horner Syndrome|Autonomic Imbalance
Interventions: PROCEDURE: Interscalene brachial plexus block|DRUG: 0.75% ropivacaine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessing Biomarker in Giant Cell Arteritis and Polymyalgia Rheumatic
Status: RECRUITING
Conditions: Giant Cell Arteritis|Polymyalgia Rheumatica
Interventions: DIAGNOSTIC_TEST: Aortic/ cardiac magnetic resonance imaging|DIAGNOSTIC_TEST: Vascular ultrasound|DIAGNOSTIC_TEST: Transorbital Ultrasound|DIAGNOSTIC_TEST: Contrast-Enhanced Ultrasound|DIAGNOSTIC_TEST: Optical coherence tomography angiography|DIAGNOSTIC_TEST: Fluorescein angiography|DIAGNOSTIC_TEST: Fundus autofluorescence|DIAGNOSTIC_TEST: Color Fundus Photography|DIAGNOSTIC_TEST: Cell-based ex-vivo assay with high-content analysis|DIAGNOSTIC_TEST: 3'mRNA sequencing|DIAGNOSTIC_TEST: Enzyme-linked immunosorbent assay|DIAGNOSTIC_TEST: Flow cytometry|DIAGNOSTIC_TEST: Laboratory assessment:|DIAGNOSTIC_TEST: Immunohistochemistry of Temporal Artery Biopsies|DIAGNOSTIC_TEST: Functional assessment questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparsion of WT and SNP Techniques of EUS-FNB in Pancreatic Solid Mass (WESP-PSM)
Status: UNKNOWN
Conditions: Pancreatic Neoplasms|Diagnoses Disease
Interventions: PROCEDURE: wet suction|PROCEDURE: standard negative pressure suction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Clinical Study to Develop a Controlled Human Infection Model Using Leishmania Major-infected Sand Flies
Status: COMPLETED
Conditions: Leishmaniasis|Cutaneous Leishmaniases|Insect Bites
Interventions: OTHER: biting by Phlebotomus duboscqi infected with Leishmania major
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Platelet-Rich Plasma (PRP) in Reconstructive Surgery on Children With Retractable Burn Sequelae on Extremities
Status: COMPLETED
Conditions: Burns
Interventions: PROCEDURE: With PRP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of Dysplasia in the Pelvic Pouch in Patients With Ulcerative Colitis (UC) and Risk Factors
Status: COMPLETED
Conditions: Ulcerative Colitis|Dysplasia|Surgery
Interventions: PROCEDURE: Endoscopy and biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Denosumab In Ebv Nasopharyngeal Carcinoma As A Model For RankMediated Immunologic Modulation Of Virus-Related Tumours
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma|EBV Related Carcinoma
Interventions: DRUG: Denosumab Inj 120 MG/1.7ML|DRUG: Chemotherapy as clinical standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Topical Application of Anaesthetics With EnkFiberoptic Atomizer During the Bronchoscopy
Status: UNKNOWN
Conditions: Flexible Bronchoscopy
Interventions: DEVICE: Enk Fiberoptic Atomizer|DEVICE: bronchoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Magnetic Resonance Guided High Intensity Focused Ultrasound in Advanced Pancreatic Adenocarcinoma Treatment
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma
Interventions: DEVICE: ExAblate 2100
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Does Hydroxychloroquine Before & During Patient Exposure Protect Healthcare Workers From Coronavirus?
Status: TERMINATED
Conditions: Pre-Exposure Prophylaxis|Coronavirus|SARS-CoV 2
Interventions: DRUG: Hydroxychloroquine|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 2a Study to Evaluate the Safety, Tolerability and Efficacy of Cannabidiol as a Steroid-sparing Therapy in Steroid-dependent Crohn's Disease Patients
Status: COMPLETED
Conditions: Steroid Dependent Crohn's Disease
Interventions: DRUG: Cannabidiol , synthetic form|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intracoronary Stenting and Additional Results Achieved by ShockWAVE Coronary Lithotripsy
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: Intravascular lithotripsy (IVL)|DEVICE: Standard non-IVL methods
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characterization of the Intestinal Microbiota in Patients With Inflammatory Bowel Disease and/or Spondyloarthritis and Study of the Impact of an Anti-TNF Alpha Therapy
Status: COMPLETED
Conditions: Spondyloarthritis|Crohn Disease|Ulcerative Colitis
Interventions: OTHER: blood sample|OTHER: stool samples|OTHER: food questionnaire|OTHER: colonoscopy|OTHER: VOCs profile
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Prospective Trial of COXEN Chemotherapy Prediction
Status: WITHDRAWN
Conditions: Ovarian Neoplasms|Fallopian Tube Neoplasms
Interventions: DEVICE: COXEN analysis for chemotherapy prediction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose:
Clinical trial: A Phase 1 Study of an Investigational Drug, ALN-PCSSC, in Subjects With Elevated Low Density Lipoprotein Cholesterol (LDL-C)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: ALN-PCSSC|DRUG: Sterile Normal Saline (0.9% NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study of VELCADE® in Combination With Other Drugs to Treat Previously Untreated Multiple Myeloma Patients
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: VELCADE (bortezomib)|DRUG: dexamethasone|DRUG: cyclophosphamide|DRUG: Revlimid (lenalidomide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Trastuzumab as Part of Breast Cancer Treatment Regimen
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Carboplatin|DRUG: Cyclophosphamide|DRUG: Docetaxel|DRUG: Doxorubicin|DRUG: Paclitaxel|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Nivolumab in Unresectable Advanced or Recurrent Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: Nivolumab|DRUG: Docetaxel/Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brexpiprazole for the Long-term Treatment of Patients With Agitation Associated With Dementia of the Alzheimer's Type
Status: COMPLETED
Conditions: Agitation Associated With Dementia of the Alzheimer's Type
Interventions: DRUG: Brexpiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychological, Physiological, Endocrine, and Pharmacokinetic Effects of LSD in a Controlled Study
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Placebo|DRUG: LSD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Audiovisual Interactive Games to Alleviate Pediatric Perioperative Anxiety
Status: ENROLLING_BY_INVITATION
Conditions: Anxiety
Interventions: DEVICE: Bedside Entertainment and Relaxation Theater (BERT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Hypnosis in Working Memory Rehabilitation
Status: RECRUITING
Conditions: Cognitive Rehabilitation|Brain Injuries|Cognitive Impairment|Working Memory
Interventions: OTHER: Hypnotic suggestion|OTHER: Mindfulness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Efficacy of Modified VCD Regimens in Previously Untreated Multiple Myeloma.
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib|DRUG: cyclophosphamide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sustained Low Efficiency Dialysis Versus Continuous Renal Replacement Therapy for Acute Kidney Injury in Critically Ill Cirrhotics
Status: COMPLETED
Conditions: Liver Cirrhosis
Interventions: PROCEDURE: Sustained Low Efficiency Dialysis (SLED)|PROCEDURE: Continuous Renal Replacement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Protocol Barostat for Assessment of Anorectal Function Versus Standard Protocol Barostat in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: anorectal manometry|DEVICE: barostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nonresponders by the Session Order Factor
Status: COMPLETED
Conditions: Morbid Obesity|Sports Physical Therapy
Interventions: BEHAVIORAL: HIIT+RT experimental group|BEHAVIORAL: RT+HIIT experimental group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Caphosol Study: Prevention of Oral Mucositis in Children, Adolescents and Young Adults Receiving Chemotherapy
Status: TERMINATED
Conditions: Oral Mucositis
Interventions: DRUG: Caphosol|DRUG: Biotene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Cost-effectiveness of Spasticity Treatment With Multifocal TENS
Status: COMPLETED
Conditions: Spasticity|Stroke|Cerebral Palsy
Interventions: DEVICE: Multifocal TENS garment (Mollii®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment Of Inlay Retained Bridge Designs (Tub Shaped And Inlay Shaped) In Missing Posterior Teeth Cases.
Status: UNKNOWN
Conditions: Missing Tooth
Interventions: OTHER: Tub shaped design|OTHER: Inlay shaped design
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Genetic Profile on Predicting Sensibility of Preoperative Chemoradiotherapy on Locally Advanced Rectal Carcinoma
Status: UNKNOWN
Conditions: Rectal Neoplasms
Interventions: RADIATION: preoperative concurrent chemoradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liquid Preterm Formula Versus Powdered Human Milk Fortifier in VLBW Infants
Status: COMPLETED
Conditions: Infant, Very Low Birth Weight
Interventions: DIETARY_SUPPLEMENT: Similac special care 30|DIETARY_SUPPLEMENT: Similac human milk fortifier
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Optimal Dosage of Ropivacaine for Arthroscopic Knee Surgery
Status: COMPLETED
Conditions: Arthroscopic Knee Surgery|Ropivacaine|Combined Spinal Epidurai Anesthesia|ED50|ED95
Interventions: DRUG: ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optical Coherence Tomography Angiography Evaluation of Ocular Changes in Patients With Carotid Artery Stenosis
Status: COMPLETED
Conditions: Carotid Stenosis
Interventions: PROCEDURE: Carotid artery revascularization procedure|DEVICE: Optical coherence tomography angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Encorafenib + Binimetinib + Pembrolizumab in Patients With Unresectable or Metastatic BRAF V600 Mutant Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: DRUG: Encorafenib|DRUG: Binimetinib|DRUG: Pembrolizumab|DRUG: Pembrolizumab alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: Ipatasertib|DRUG: Cobimetinib|DRUG: Trastuzumab Emtansine|DRUG: Atezolizumab|DRUG: Bevacizumab|DRUG: Paclitaxel|DRUG: Giredestrant|DRUG: Abemaciclib|DRUG: Inavolisib|DRUG: Palbociclib|DRUG: Letrozole|DRUG: Olaparib|DRUG: Luteinizing Hormone-Releasing Hormone (LHRH) Agonists|DRUG: Cyclophosphamide|DRUG: Inavolisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sitravatinib and Tislelizumab in Patients With Metastatic Uveal Melanoma With Liver Metastases.
Status: ACTIVE_NOT_RECRUITING
Conditions: Uveal Melanoma
Interventions: DRUG: Tislelizumab|DRUG: Sitravatinib Malate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ⅱa Study of the Safety, Tolerability and Efficacy of BD111 in Herpes Simplex Virus Type I Stromal Keratitis
Status: NOT_YET_RECRUITING
Conditions: Herpes Simplex Virus Type I Stromal Keratitis
Interventions: GENETIC: BD111 Injection (investigational new drug)|COMBINATION_PRODUCT: Triple-drugs therapy of HSV-1 stromal keratitis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Tricuspid Heart Valve Replacement Study
Status: NOT_YET_RECRUITING
Conditions: Tricuspid Valve Regurgitation|Heart Valve Diseases|Cardiovascular Diseases
Interventions: DEVICE: Transcatheter Tricuspid Valve Replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Efficacy and Safety of DRT VS CRT Plus Surgery in Patients Who Achieved CCR for Esophageal Cancer
Status: UNKNOWN
Conditions: Stage II Esophageal Cancer|Stage III Esophageal Cancer
Interventions: COMBINATION_PRODUCT: Definitive Radiochemotherapy|COMBINATION_PRODUCT: Neoadjuvant Radiochemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Varied Outreach Methods on Appointment Scheduling, Appointment Completion, and Receipt of MMR Vaccination
Status: COMPLETED
Conditions: Preventable Disease, Vaccine|Health Care Utilization
Interventions: OTHER: 1 automated message|OTHER: 2 automated messages|OTHER: No personal contact attempt|OTHER: 1 personal contact attempt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of the Hemispheric Specialization for Language in Subjects With Neuropsychiatric Disorders Compared to Control Subjects
Status: COMPLETED
Conditions: Neuropsychiatric Disorders
Interventions: DEVICE: IMRf|OTHER: language task and a reference task (rest and Tamil)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Evaluate the Efficacy and Safety/Tolerability Profiles of G-CSF in Subjects With Mild to Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Filgrastim (75mcg/0.3ml)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin for the Treatment of Premature Pubarche in Girls
Status: TERMINATED
Conditions: Premature Pubarche
Interventions: DRUG: sugar pill|DRUG: Metformin, glucophage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nafamostat Efficacy in Phase 3 Registrational CRRT Study
Status: RECRUITING
Conditions: Acute Kidney Injury
Interventions: DEVICE: Niyad (nafamostat mesylate)|DEVICE: Placebo (0.9% NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telephone Outreach by Navigators to Improve Repeat Fecal Occult Blood Testing
Status: UNKNOWN
Conditions: Colorectal Cancer Screening
Interventions: BEHAVIORAL: telephone outreach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Communication Skills vs. Mindfulness for IPV
Status: UNKNOWN
Conditions: Domestic Violence|Domestic Abuse|Family Conflict|Aggression
Interventions: BEHAVIORAL: Communication Skills Training|BEHAVIORAL: Mindfulness|BEHAVIORAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Flaxseed Supplement in Treating Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Undergoing Chemotherapy and Radiation Therapy
Status: TERMINATED
Conditions: Lung Cancer|Radiation Toxicity
Interventions: DIETARY_SUPPLEMENT: flaxseed|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Pain Difference for 'IV Paracetamol' and TAP Block' in Acute Cholecystitis
Status: UNKNOWN
Conditions: Transversus Abdominis Plane (TAP) Block
Interventions: DRUG: Intravenous Infusion|PROCEDURE: Local anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Islet Transplantation in Type 1 Diabetic Patients Using the University of Illinois at Chicago (UIC) Protocol
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 1 Diabetes Mellitus
Interventions: BIOLOGICAL: Islets of Langerhans transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of Bicarbonate-calcium Water in Premenopausal and Postmenopausal Women as a Prevention of Osteoporosis
Status: COMPLETED
Conditions: Osteoporosis Risk
Interventions: OTHER: bicarbonate-calcium water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Diaphragm Movement After an Interscalene Block
Status: COMPLETED
Conditions: Phrenic Nerve Paralysis
Interventions: DRUG: liposomal bupivacaine|DRUG: bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Left Atrial Appendage Closure With SentreHeart Lariat® Device
Status: COMPLETED
Conditions: Cardioembolic Stroke|Atrial Fibrillation
Interventions: PROCEDURE: Left atrial appendage closure|DEVICE: SentreHeart Lariat®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pre-and-post Study With a Nested Randomized Trial of Digital Training to Teach Problem-solving Counselling in India
Status: COMPLETED
Conditions: Depression, Anxiety
Interventions: OTHER: Digital Training with Coaching (DT-C)|OTHER: Self-Guided Digital Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Phase III Study to Investigate the Impact of Diamyd in Patients Newly Diagnosed With Type 1 Diabetes (USA)- DIAPREVENT
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: rhGAD65|DRUG: rhGAD65|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study To Evaluate The Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of Pf-05230907 In Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: PF-05230907|DRUG: Placebo for PF-05230907|BIOLOGICAL: PF-05230907|DRUG: Placebo for PF-05230907|BIOLOGICAL: PF-05230907|DRUG: Placebo for PF-05230907|BIOLOGICAL: PF-05230907|DRUG: Placebo for PF-05230907|BIOLOGICAL: PF-05230907|DRUG: Placebo for PF-05230907|BIOLOGICAL: PF-05230907|DRUG: Placebo for PF-05230907
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Insomnia in Elderly Sleep Apnea Patients With Ramelteon (TAK 375)
Status: COMPLETED
Conditions: Insomnia|Obstructive Sleep Apnea
Interventions: DRUG: rozerem|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GB1275 Monotherapy and in Combination With an Anti-PD1 Antibody in Patients With Specified Advanced Solid Tumors or in Combination With Standard of Care in Patients With Metastatic Pancreatic Adenocarcinoma
Status: TERMINATED
Conditions: Pancreatic Adenocarcinoma|Esophageal Adenocarcinoma|Esophageal Squamous Cell Carcinoma|Gastric Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma|Triple Negative Breast Cancer|Castration-resistant Prostate Cancer|Microsatellite Stable Colorectal Cancer|Non-small Cell Lung Cancer|Small-cell Lung Cancer|Head and Neck Squamous Cell Carcinoma|Urothelial Carcinoma|Renal Cell Carcinoma|Hepatocellular Carcinoma
Interventions: DRUG: GB1275|DRUG: nab-paclitaxel and gemcitabine|DRUG: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Six-Minute Walking Test (6WT) and Timed-Up-and-Go (TUG) Test as Measures of Objective Functional Impairment in Patients Undergoing Interlaminar or Transforaminal Epidural Steroid Injection for Lumbar Degenerative Disc Disease (DDD)
Status: COMPLETED
Conditions: Lumbar Disc Disease|Lumbar Spine Degeneration|Lumbar Spinal Stenosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Telerehabilitation Based Exercise Training in Parkinson's Patients
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease|Respiration|Gait Disorders, Neurologic
Interventions: OTHER: Breathing exercises|OTHER: Core stabilization exercises|OTHER: Balance and strengthening exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of rFVIIIFc for Immune Tolerance Induction (ITI) in Haemophilia A Patients With Inhibitors Who Have Failed Previous ITI Therapies
Status: COMPLETED
Conditions: Hemophilia A
Interventions: BIOLOGICAL: Recombinant coagulation factor (rFVIIIFc)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Phase IIa Study of Myelo001 in Chemotherapy-Induced Neutropenia
Status: COMPLETED
Conditions: Chemotherapy-Induced Neutropenia|Myelosuppression|Breast Cancer
Interventions: DRUG: Myelo001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Irritancy/Allergic Sensitivity to Natural Personal-care Products by Patch Tests
Status: UNKNOWN
Conditions: Cutaneous Patch|Dermatitis|Allergy|Cosmetic Allergy|Eczema; Contact, Allergic
Interventions: OTHER: patch tests on healthy skin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effect of Grape Seed Extract Plus Ascorbic Acid on Endothelial Function
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DIETARY_SUPPLEMENT: Grape seed extract and ascorbic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clofarabine Plus Low-Dose Cytarabine for Patients With Higher-Risk Myelodysplastic Syndrome (MDS)
Status: COMPLETED
Conditions: Leukemia|Myeloproliferative Diseases
Interventions: DRUG: Clofarabine|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 124I-Metaiodobenzylguanidine (MIBG) PET/CT Diagnostic Imaging and Dosimetry for Patients With Neuroblastoma: A Pilot Study
Status: TERMINATED
Conditions: Neuroblastoma
Interventions: DRUG: 124I-Metaiodobenzylguanidine (MIBG) (no-carrier added)|DRUG: 124I-MIBG (carrier added)|PROCEDURE: Positron Emission Tomography (PET) /Computerized tomography (CT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Oral Rehydration Therapy Supplemented With Zinc in the Management of Diarrhea Acute
Status: UNKNOWN
Conditions: Diarrhea|Children
Interventions: OTHER: Zinc group|OTHER: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Daily Nitrate Consumption on Oral Bacteria Composition, Blood Pressure and Vascular Function
Status: COMPLETED
Conditions: No Dental Disease|Non-smoking
Interventions: OTHER: Nitrate rich beetroot juice|OTHER: Placebo beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Amiodarone Against ICD Therapy in Chagas Cardiomyopathy for Primary Prevention of Death
Status: UNKNOWN
Conditions: Chagas Cardiomyopathy|Non-sustained Ventricular Tachycardia|At Least 10 Points in Rassi Risk Score for Death
Interventions: PROCEDURE: ICD implantation|DRUG: amiodarone hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hybrid Evaluation of a Home-based HIV Pre-exposure Prophylaxis Program
Status: RECRUITING
Conditions: HIV Prevention|Pre-exposure Prophylaxis|STI
Interventions: OTHER: Health service - home-based PrEP monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Focal Radiation With Pulsed Systemic Therapy of Abiraterone, Androgen Deprivation Therapy (ADT), Lynparza Towards Castration Sensitive Oligometastatic Prostate Cancer (FAALCON)
Status: RECRUITING
Conditions: Prostate Cancer|Castrate Sensitive Prostate Cancer|Oligometastatic Disease
Interventions: DRUG: Abiraterone|DRUG: Prednisone|RADIATION: External Beam Radiotherapy|BIOLOGICAL: Androgen Deprivation Therapy (ADT)|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Trogocytosis a Predictive Marker of CAR-T Cell Response in Diffuse Large B-cell Lymphoma?
Status: RECRUITING
Conditions: Diffuse Large B Cell Lymphoma
Interventions: OTHER: Flow cytometry analysis to determine the level of trogocytosis by effector immune cells in patients|OTHER: Flow cytometry analysis to determine the level of trogocytosis by effector immune cells in volunteers
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A First Human Dose Trial Investigating Safety, Tolerability and Pharmacokinetics for Single Doses of NNC9204-1177 in Subjects Being Overweight or With Obesity.
Status: COMPLETED
Conditions: Metabolism and Nutrition Disorder|Obesity
Interventions: DRUG: NNC9204-1177|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Added Value of OCT for Diagnosing Recurrent BCC After Non-invasive Treatment
Status: COMPLETED
Conditions: Basal Cell Carcinoma
Interventions: DIAGNOSTIC_TEST: Punch biopsy (3mm)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase 1, Open Label, Two Arm, Fixed Sequence Study to Evaluate the Effect of Rifampin and Rifabutin on GSK1349572 Pharmacokinetics in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: GSK1349572|DRUG: Rifampin|DRUG: Rifabutin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characteristics of Hypophosphatasia in Adult Patients in Rheumatology
Status: RECRUITING
Conditions: Hypophosphatasia
Interventions: DIAGNOSTIC_TEST: Second alkaline phosphatase measurement|DIAGNOSTIC_TEST: Extended laboratory diagnostics|DIAGNOSTIC_TEST: Symptom and clinical findings checklist for hypophosphatasia|DIAGNOSTIC_TEST: SF-36|DIAGNOSTIC_TEST: Short physical performance battery (SPPB) score|DIAGNOSTIC_TEST: Physical examination|DIAGNOSTIC_TEST: Recording of vital signs|DIAGNOSTIC_TEST: Bioelectrical Impedance Analysis|DIAGNOSTIC_TEST: Genetic testing of the alkaline phosphatase gene
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: IN Dexmedetomidine for Procedural Sedation in Pediatric Closed Reductions for Distal Forearm Fractures
Status: UNKNOWN
Conditions: Conscious Sedation|Distal Radius Fracture
Interventions: DRUG: Dexmedetomidine|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Evaluation of Different Medication Combination in Type 2 Diabetes Treatment
Status: COMPLETED
Conditions: Diabetes Type 2
Interventions: DRUG: Insulin-Levemir|DRUG: Exenatide-Bayetta|DRUG: Insulin-Levemir and Exenatide-Bayetta|DEVICE: SenseWear Pro3® armband|DEVICE: DexCom CGM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted Immunotherapy After Myeloablative TBI-Based Conditioning & AlloHCT in CAYA With High Risk T-Cell ALL & Lymphoma
Status: RECRUITING
Conditions: T-cell Acute Lymphoblastic Leukemia|T-Cell Acute Lymphoblastic Lymphoma
Interventions: DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Perfusion Measurement - a Feasibility and Usability Study
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DEVICE: Q-ICG|PROCEDURE: White light perfusion assessment|PROCEDURE: Fluorescence angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: NovoTTF-200A Together With Radiation Therapy and Temozolomide in Patients With Newly Diagnosed GBM
Status: UNKNOWN
Conditions: Glioblastoma
Interventions: DEVICE: NovoTTF-200A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Efficacy and Safety of Thrice Daily Versus Twice Daily NovoMix® 30 (Biphasic Insulin Aspart 30) in Subjects With Type 2 Diabetes Inadequately Controlled With Basal Insulin
Status: COMPLETED
Conditions: Diabetes|Type 2 Diabetes Mellitus
Interventions: DRUG: biphasic insulin aspart 30
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VA Augmentation and Switching Treatments for Improving Depression Outcomes
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Switching: Bupropion-SR|DRUG: Augmenting: Antidepressant + Bupropion-SR|DRUG: Augmenting: Antidepressant + Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of a PARP Inhibitor for the Treatment of BRCA-positive Advanced Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Neoplasm
Interventions: DRUG: KU-0059436 (AZD2281)(PARP inhibitor)|DRUG: KU-0059436 (AZD2281)(PARP inhibitor)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-modality Imaging (PCa) Using Sodium MRI and PSMA PET in Men Pre-prostatectomy
Status: RECRUITING
Conditions: Prostate Cancer|Prostate Adenocarcinoma|Prostate Neoplasm
Interventions: DIAGNOSTIC_TEST: PET Scan|DRUG: [18F]PSMA-1007 Injection|DIAGNOSTIC_TEST: Sodium MRI|DIAGNOSTIC_TEST: Multiparametric MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Relative Bioavailability and Food-Effect Study of GSK3640254 Tablet and Capsule Formulations in Healthy Participants
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: GSK3640254 Tablet|DRUG: GSK3640254 Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Tolerability, Efficacy, and Safety of HSK3486 Injectable Emulsion in Patients
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: HSK3486|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT