pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Calcium for Prevention of Ovarian Hyperstimulation Syndrome
Status: COMPLETED
Conditions: Ovarian Hyperstimulation Syndrome
Interventions: DRUG: calcium|DRUG: 0.9 % saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PRCT-study of Different Non-operative Treatment Protocols of ER-stress Negative Weber-B Unimalleolar Ankle Fractures.
Status: COMPLETED
Conditions: Lateral Malleolus Fractures
Interventions: OTHER: Splint 3 weeks|OTHER: Cast 3 weeks|OTHER: Cast 6 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Two-part Study to Investigate the Interaction and Pharmacokinetics of GSK2586184
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: GSK2586184 standard formulation|DRUG: Simvastatin|DRUG: Rosuvastatin|DRUG: GSK2586184 new formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Human Endostatin(Rh-endostatin) Combine With Radiotherapy in the Treatment of Hepatocellular Carcinoma(HCC)
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: recombinant human endostatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficacy and Safety of TachoSil® Versus Surgicel® Original for the Secondary Hemostatic Treatment of Needle Hole Bleeding in Vascular Surgery
Status: COMPLETED
Conditions: Bleeding
Interventions: DRUG: TachoSil®|DRUG: Surgicel® Original
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Beta-2 Agonist Versus Epinephrine For Treatment of Transient Tachypnea of Newborn (TTN)
Status: COMPLETED
Conditions: Transient Tachypnea of the Newborn
Interventions: DRUG: Epinephrine Inhalation Solution|DRUG: Salbutamol|DRUG: Saline Inhalants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sequential Treatment of Psoriasis With Traditional Chinese and Western Medicine
Status: NOT_YET_RECRUITING
Conditions: Plaque Psoriasis
Interventions: DRUG: Ixekizumab+Jueyin Granules|DRUG: Ixekizumab+Jueyin placebo Granules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Implantable Phakic Lens (IPCL) VS Implantable Collamer Lens
Status: UNKNOWN
Conditions: Myopia
Interventions: PROCEDURE: Implantable Collamer Lens (ICL) in treatment of myopia in adults.|PROCEDURE: Implantable Intraocular Lens (IPCL) in treatment of myopia in adults.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epigenetic Effects Involved in Children With Cow's Milk Allergy (EPICMA)
Status: COMPLETED
Conditions: Cow's Milk Allergy
Interventions: DIETARY_SUPPLEMENT: Extensively hydrolyzed casein formula plus Lactobacillus rhamnosus GG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Trial of ALIMTA (LY231514, Pemetrexed) Plus GEMZAR Versus GEMZAR in Patients With Unresectable or Metastatic Cancer of the Pancreas.
Status: COMPLETED
Conditions: Pancreatic Neoplasms|Metastases, Neoplasm
Interventions: DRUG: GEMZAR|DRUG: ALIMTA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Kidney Transplant Recipients
Status: COMPLETED
Conditions: Kidney Transplant Rejection
Interventions: BIOLOGICAL: CFZ533 - MMF - CS|DRUG: Tacrolimus - MMF - +/- corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity, Safety and Tolerability of a Neisseria Meningitidis Serogroup B Bivalent Recominant Lipoprotein 2086 Vaccine (Bivalent rLP2086) in Healthy Toddlers.
Status: COMPLETED
Conditions: Meningococcal B Disease
Interventions: BIOLOGICAL: rLP2086 vaccine|BIOLOGICAL: Pediatric HAV vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Washed Microbiota Transplantation for Malnutrition After Upper Gastrointestinal Rerouting Surgery
Status: UNKNOWN
Conditions: Malnutrition|Upper Gastrointestinal Rerouting Surgery
Interventions: OTHER: washed microbiota transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment
Status: UNKNOWN
Conditions: Congenital Adrenal Hyperplasia
Interventions: DRUG: Conventional Glucocorticoids (immediate release hydrocortisone, cortisone acetate, prednisone, prednisolone, dexamethasone)|DRUG: Dual release hydrocortisone (plenadren)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Cytochrome P450 4F Enzymes and Drug Interactions
Status: COMPLETED
Conditions: Healthy Volunteers|Drug Drug Interactions
Interventions: DRUG: Warfarin|DRUG: Placebo|DRUG: Lovastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Dose-escalation and Safety & Efficacy Study of AXO-AAV-GM2 in Tay-Sachs or Sandhoff Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Tay-Sachs Disease|Sandhoff Disease
Interventions: BIOLOGICAL: AXO-AAV-GM2 Starting Dose|BIOLOGICAL: AXO-AAV-GM2 Low Dose|BIOLOGICAL: AXO-AAV-GM2 Middle Dose|BIOLOGICAL: AXO-AAV-GM2 High Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reflexology Socks and Opioid-induced Constipation
Status: COMPLETED
Conditions: Opioid Use|Constipation|Reflexology
Interventions: OTHER: Reflexology socks+walking|OTHER: Just walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Romidepsin Plus Oral 5-Azacitidine in Relapsed/Refractory Lymphoid Malignancies
Status: TERMINATED
Conditions: Lymphoid Malignancies|Lymphoma|Hodgkin Lymphoma|Non-hodgkin Lymphoma
Interventions: DRUG: RomiDEPsin 10 MG/M2|DRUG: Oral 5-Azacitidine 100 MG|DRUG: Romidepsin 14 MG/M2|DRUG: Oral 5-Azacitidine 200 MG|DRUG: Oral 5-Azacitidine 300 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tele-spirometry in Primary Care-Randomized Clinical Trial Cluster:Telemedicine in Chronic Obstructive Pulmonary Disease
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Spirometry|OTHER: telemonitoring|OTHER: teleconsultation|OTHER: Spirometry - 20 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Risdiplam (RO7034067) in Healthy Japanese Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Risdiplam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Application of 18F-PFPN PET Imaging in Diagnosis and Staging of Clear Cell Sarcoma of Soft Tissue
Status: RECRUITING
Conditions: Clear Cell Sarcoma of Soft Tissue
Interventions: DRUG: 18F-PFPN
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparing Hand-sewn (END-TO-END or Kono-S) to Stapled Anastomosis in Ileocolic Resection for Crohn's Disease
Status: RECRUITING
Conditions: Crohn Disease
Interventions: PROCEDURE: stapled side-to-side anastomosis|PROCEDURE: Handsewn anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Biotyping of FSHD Patients and Controls
Status: COMPLETED
Conditions: Muscular Dystrophy, Facioscapulohumeral
Interventions: BEHAVIORAL: CHDR Monitoring Remotely (MORE)|BEHAVIORAL: Withings Steel HR|BEHAVIORAL: Withings Body+ scale|BEHAVIORAL: Withings Blood Pressure Monitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Safety Study in Participants With Advanced Solid Tumors
Status: TERMINATED
Conditions: Advanced Solid Tumors
Interventions: DRUG: Gemcitabine|DRUG: Docetaxel|DRUG: Temozolomide|DRUG: Cisplatin|DRUG: Erlotinib|DRUG: LY573636
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Repeatability Study of Fatty Acid Uptake Using PET/MR Imaging in Patients With T2DM and Non-diabetic Control Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Imaging Biomarkers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: COVID-19: Healthy Oregon (Oregon Saludable): Together We Can (Juntos Podemos) Phase II
Status: COMPLETED
Conditions: Health Behavior|Health Care Utilization
Interventions: BEHAVIORAL: Phase II Promotores de Salud|BEHAVIORAL: Phase I Promotores de Salud Outreach
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Reduction in the Risk of Rejection by Mycophenolate Mofetil Dose Adjustment in Liver Transplant Patients With Side Effects Caused by the Calcineurine Inhibitors
Status: COMPLETED
Conditions: Liver Transplantation
Interventions: DRUG: Mycophénolate Mofétil|DRUG: Ciclosporine A|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive - Motor Dual Task and Swallowing
Status: UNKNOWN
Conditions: DUAL TASK|DEGLUTİTİON|COGNİTİVE FUNCTİON|ACTİVİTİES OF DAİLY LİVİNG
Interventions: OTHER: Observation of visual, audotory and motor reaction time
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CD70-targeted CAR-NKT Cells(CGC729) Therapy in the Renal Cell Carcinoma
Status: RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: COMBINATION_PRODUCT: Cyclophosphamide + Fludarabine + Infusion of CAR-NKT Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigational Immuno-therapy Safety Trial of Nivolumab in Patients With Advanced or Metastatic Renal Cell Carcinoma
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Ventilator Pressure and Optimization of Compliance and Hemodynamics
Status: NOT_YET_RECRUITING
Conditions: Bronchopulmonary Dysplasia|Pulmonary Hypertension Due to Lung Diseases and Hypoxia|Extreme Prematurity|Ventilator Lung; Newborn|Ventilation Perfusion Mismatch
Interventions: OTHER: Increase in the PEEP followed by decrease in the PEEP|OTHER: Decrease in the PEEP followed by increase in the PEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protocol for Staged Stereotactic Radiosurgery for Large Arteriovenous Malformations
Status: COMPLETED
Conditions: Intracranial Arteriovenous Malformations (AVM)
Interventions: PROCEDURE: Fractionated stereotactic radiosurgery|DEVICE: Leskell gamma unit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Moderate to High Intensity Aerobic Interval Training on Polysomnographic Measured Sleep in Patients With Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Sleep Disturbances
Interventions: BEHAVIORAL: High intensity aerobic interval training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Treatment of Smoking Among Individuals With PTSD
Status: COMPLETED
Conditions: Cigarette Smoking|Nicotine Dependence|Post-traumatic Stress Disorder|Tobacco Use Disorder
Interventions: DRUG: Varenicline|BEHAVIORAL: Medication Management Counseling|BEHAVIORAL: Prolonged Exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cross-Disciplinary Workplace Intervention Strategy for Chronic Musculoskeletal Disorders
Status: UNKNOWN
Conditions: Back Pain|Neck Pain|Musculoskeletal Abnormalities
Interventions: PROCEDURE: combined intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Mental Health in Orthopedic Surgery
Status: RECRUITING
Conditions: Orthopedic Surgery|Older Adults|Depression|Anxiety
Interventions: BEHAVIORAL: Behavioral activation|OTHER: Medication optimzation|OTHER: Care as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison Study of Bypassing Agent Therapy With and Without Tranexamic Acid in Haemophilia A Patients With Inhibitor
Status: COMPLETED
Conditions: Hereditary Factor VIII Deficiency Disease With Inhibitor
Interventions: DRUG: aPCC, aPCC + TXA|DRUG: rFVIIa, rFVIIa + TXA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Are Sutures Required in Total Abdominal Hysterectomy? A Randomised Control Trial
Status: UNKNOWN
Conditions: Total Abdominal Hysterectomy
Interventions: PROCEDURE: Performing abdominal hysterectomy using gyrus electrocoagulation forceps
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Resistant Depression by Repetitive Transcranial Magnetic Stimulation (rTMS) Multicentric Naturalistic Study
Status: RECRUITING
Conditions: To Evaluate the Effectiveness of Open rTMS
Interventions: DEVICE: rTMS basic|DEVICE: rTMS VIIT|DEVICE: rTMS SAINT modified|DEVICE: rTMS SAINT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of the Safety and Efficacy of LDP-02 in Mildly to Moderately Active Crohn's Patients
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: LDP-02|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Dowling Maera Type of Epidermolysis Bullosa Simplex by Oral Erythromycin
Status: UNKNOWN
Conditions: Epidermolysis Bullosa
Interventions: DRUG: Oral erythromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-transplant Autologous Cytokine-induced Killer (CIK) Cells for Treatment of High Risk Hematologic Malignancies
Status: COMPLETED
Conditions: Leukemia|Multiple Myeloma
Interventions: DRUG: CIK cells|DRUG: etoposide|DRUG: bcnu|DRUG: cyclophosphamide|DRUG: gemcitabine|DRUG: vinorelbine|DRUG: melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Olive Leaf Extract as Part of a Healthy Lifestyle in the Reduction of Blood Pressure
Status: COMPLETED
Conditions: Pre Hypertension
Interventions: DIETARY_SUPPLEMENT: Olive leaf extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lupus Immunosuppressive/Immunomodulatory Therapy or Stem Cell Transplant (LIST)
Status: WITHDRAWN
Conditions: Systemic Lupus Erythematosus
Interventions: PROCEDURE: Leukapheresis|PROCEDURE: Non-myeloablative high dose immunosuppressive therapy conditioning (HDIT)|PROCEDURE: Autologous CD34+HPC transplantation (HSCT)|PROCEDURE: Plasmapheresis|DRUG: Rabbit anti-thymocyte globulin|DRUG: Methylprednisolone|DRUG: Growth colony stimulating factor (G-CSF)|DRUG: Corticosteroids|DRUG: Mycophenolate mofetil|DRUG: Azathioprine|DRUG: Intravenous immunoglobulin|DRUG: Methotrexate|DRUG: Rituximab|DRUG: Leflunomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Function of PA, RBP and TRSF in Malnutrition Detecting and Nutritional Status Monitoring for NPC Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Nasopharyngeal Carcinoma|Malnutrition
Interventions: DRUG: cisplatin and docetaxel|RADIATION: IMRT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: N99-02: Melphalan and Buthionine Sulfoximine
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: DRUG: buthionine sulfoximine|DRUG: melphalan|PROCEDURE: Peripheral blood stem cell infusion|OTHER: Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed and Carboplatin With or Without Anlotinib Hydrochloride for Osimertinib-resistant Non-squamous NSCLC
Status: UNKNOWN
Conditions: NSCLC Stage IV
Interventions: DRUG: Pemetrexed|DRUG: Carboplatin|DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Efficacy, Safety and Tolerability of Romosozumab Treatment in Postmenopausal Chinese Women With Osteoporosis
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Romosozumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aspiration for Pain Relief Following Ankle Fracture
Status: COMPLETED
Conditions: Ankle Fracture
Interventions: PROCEDURE: Ankle Aspiration|PROCEDURE: Ankle aspiration Standard Anterolateral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Spanish-Language Intervention to Enhance Routine HIV Patient Care Delivery [CARE+ Spanish]
Status: COMPLETED
Conditions: HIV Infections
Interventions: OTHER: CARE+ Spanish computer counseling session|OTHER: CARE+ Spanish brief computer risk assessment session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Oral Amino Acid Nutrition to Improve Glucose Excursions in PCOS
Status: COMPLETED
Conditions: Polycystic Ovarian Syndrome|Obesity|Hepatic Steatosis
Interventions: DIETARY_SUPPLEMENT: Essential Amino Acid (EAA) Supplement|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E6742 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: E6742|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pilot Study of Total Body Irradiation in Combination With Cyclophosphamide, Anti-thymocyte Globulin, and Autologous CD34-Selected Peripheral Blood Stem Cell Transplantation in Children With Refractory Autoimmune Disorders
Status: COMPLETED
Conditions: Systemic Sclerosis|Systemic Lupus Erythematosus|Dermatomyositis|Juvenile Rheumatoid Arthritis|Autoimmune Diseases
Interventions: PROCEDURE: Stem Cell Transplantation|DEVICE: CD34 selection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A RCT of Psychosocial Interventions Facilitating Positive Psychological Adaptation in Breast Cancer
Status: ENROLLING_BY_INVITATION
Conditions: Breast Cancer Female
Interventions: BEHAVIORAL: T-CBSM|BEHAVIORAL: Support group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Combination Carboplatin Plus Celecoxib in Heavily Pre-treated Recurrent Ovarian Cancer Patients
Status: COMPLETED
Conditions: Ovarian Neoplasms
Interventions: DRUG: Carboplatin plus Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study Comparing Respimat ® Budesonide With Turbohaler ® Budesonide in Symptomatic Adult Moderate to Severe Asthmatics Requiring Inhaled Corticosteroids and Bronchodilator Therapy
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Respimat® Budesonide low dose|DRUG: Respimat® Budesonide high dose|DRUG: Turbohaler® Budesonide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Eccentric Exercises in Individuals With Frozen Shoulder
Status: RECRUITING
Conditions: Frozen Shoulder|Capsulitis, Adhesive|Capsulitis of Shoulder
Interventions: OTHER: Physical therapy interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of K9 in Subjects With Thyroid Eye Disease (TED)
Status: RECRUITING
Conditions: Thyroid Eye Disease
Interventions: DRUG: Kamuvudine-9|DRUG: Kamuvudine-9
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Representation and Medication Use in Juvenile Idiopathic Arthritis
Status: COMPLETED
Conditions: Juvenile Idiopathic Arthritis
Interventions: OTHER: Interviews with parents of children with juvenile idiopathic arthritis|OTHER: Interviews with children with juvenile idiopathic arthritis|OTHER: Interviews with Physicians
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tip Bendable Suction Ureteral Access Sheath vs. Traditional Ureteral Access Sheath in Retrograde Intrarenal Stone Surgery
Status: COMPLETED
Conditions: Kidney Stone
Interventions: PROCEDURE: Tip bendable suction ureteral access sheath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Presentation, Clinical Course and Patterns of Myocardial Damage Due to Viral Myocarditis
Status: UNKNOWN
Conditions: Viral Myocarditis
Interventions: DIAGNOSTIC_TEST: ELIZA, Extraction of nucleic acid ,Determination of viral genome by using PCR, Quantitative real-time PCR to assess viral load ,Immunohistochemistry analysis of EMB.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fat and Glucose Metabolism in Fed and Fasted State in Patients With Low Skeletal Muscle Mass
Status: COMPLETED
Conditions: Spinal Muscular Atrophy|Merosin Deficient Congenital Muscular Dystrophy
Interventions: OTHER: Fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Continuous Feeding and Sequential Feeding on Gut Microbiota and Metabolomics in Critically Ill Patients
Status: COMPLETED
Conditions: Feeding Behavior
Interventions: BEHAVIORAL: continous feeding|BEHAVIORAL: sequential feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dynamic Neural Systems Underlying Social-emotional Functions in Older Adults
Status: RECRUITING
Conditions: Loneliness|Older Adults|fMRI|Emotions|EEG|Digital Intervention|Meditation
Interventions: BEHAVIORAL: intervention|BEHAVIORAL: waitlist control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of LNK01001 Capsule in Moderately to Severely Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: LNK01001 Dose A|DRUG: LNK01001 Dose B|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Routine Deworming on Weight of Children
Status: COMPLETED
Conditions: Soil Transmitted Helminths
Interventions: DRUG: Albendazole|DIETARY_SUPPLEMENT: Calcium 400 mg + Vitamin D 2.5 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Non-comparative Study of IFX-1 Alone or IFX-1+Pembrolizumab in Patients With Locally Advanced or Metastatic cSCC.
Status: TERMINATED
Conditions: SCC - Squamous Cell Carcinoma of Skin
Interventions: DRUG: IFX-1|DRUG: IFX-1 + pembrolizumab combination therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide (VIP) in Episodic Migraine Patients
Status: COMPLETED
Conditions: Migraine|Pain|Neurologic Manifestations|Signs and Symptoms|Brain Diseases|Central Nervous System Diseases
Interventions: DRUG: Vasoactive Intestinal Polypeptide (VIP)|DRUG: Sterile saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: An Intervention Integrating Physical Therapy Exercise and Dance Movement Therapy for Preventing Falls in Older Adults
Status: NOT_YET_RECRUITING
Conditions: Older Adults
Interventions: OTHER: Physical Therapy Exercise and Dance Movement Therapy (PTE+DMT) for Preventing Falls|OTHER: Physical Therapy Exercise (PTE) only for Preventing Falls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Spinal Cord Stimulation After Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries|Spinal Cord Diseases
Interventions: DEVICE: Trans-spinal electrical stimulation|DEVICE: Electrical muscle activation|OTHER: Treadmill walking
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of GVG for the Treatment of Methamphetamine Dependence
Status: COMPLETED
Conditions: Methamphetamine Addiction
Interventions: DRUG: GVG|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Azithromycin to Prevent Wheezing Following Severe RSV Bronchiolitis-II
Status: COMPLETED
Conditions: Respiratory Syncytial Virus, Bronchiolitis
Interventions: DRUG: Oral azithromycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Standard Chemotherapy vs. Chemotherapy Guided by Cancer Stem Cell Test in Recurrent Glioblastoma
Status: COMPLETED
Conditions: Recurrent Glioblastoma
Interventions: DIAGNOSTIC_TEST: ChemoID assay|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetic (PK) Assessment of BIBR 1048 in Patients After Primary Elective Total Hip Replacement Surgery
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DRUG: BIBR 1048 capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Trazodone in OSA-MCI
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild Cognitive Impairment|Obstructive Sleep Apnea
Interventions: DRUG: Trazodone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cetuximab Re-challenge for Colorectal Cancer Liver Metastasis
Status: UNKNOWN
Conditions: Colorectal Cancer|Liver Metastases|Cetuximab
Interventions: DRUG: Cetuximab|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase Ib of L-NMMA and Pembrolizumab
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Lung Cancer|Malignant Melanoma|Head and Neck Squamous Cell Carcinoma|Classical Hodgkin Lymphoma|Urothelial Carcinoma Bladder|DNA Repair-Deficiency Disorders
Interventions: DRUG: L-NMMA|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resistance Training to Improve Fatigue and Physical Function in Postmenopausal Breast Cancer Survivors
Status: COMPLETED
Conditions: Cancer
Interventions: OTHER: Resistance training (RT)|BEHAVIORAL: Cognitively-based compassion training control (CBCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Foot Deformities on Physical Activity, Fatigue Level and Quality of Life in Elderly COPD Patients
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease|Foot Deformities|Quality of Life|Activity, Motor|Fatigue
Interventions: BEHAVIORAL: The COPD Assessment Test|DIAGNOSTIC_TEST: Navicular Drop Test|BEHAVIORAL: International Physical Activity Questionnaires (IPAQ)|BEHAVIORAL: COPD and Asthma Fatigue Scale (CAFS)|BEHAVIORAL: Saint George Respiratory Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of the Effectiveness of Osteopathic Manipulative Treatment in Pregnant Women
Status: COMPLETED
Conditions: Low Back Pain|Musculoskeletal Diseases|Pregnancy Complications
Interventions: PROCEDURE: Osteopathic manipulative treatment (OMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: MUSIDORE PED Study
Status: COMPLETED
Conditions: Pain Management|Music Therapy
Interventions: DEVICE: Pain evaluation ( FLACC scale) before and during the cleaning care with and without music therapy.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Randomized Controlled Trial of Stress Reduction on Cardiovascular Morbidity and Mortality in African Americans
Status: COMPLETED
Conditions: Coronary Heart Disease|Cardiovascular Disease
Interventions: BEHAVIORAL: Transcendental Meditation|BEHAVIORAL: Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prospective Trial of Arthroscopic Meniscectomy for Degenerative Meniscus Tears
Status: COMPLETED
Conditions: Meniscus Tear
Interventions: PROCEDURE: Randomized Meniscectomy|PROCEDURE: Randomized Lavage|PROCEDURE: Standard of Care Meniscectomy Pre-Amend|PROCEDURE: Standard of Care Meniscectomy Post-Amend
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Microwave Ablation for Mild-to-moderate Secondary Hyperparathyroidism Patients Undergoing Hemodialysis
Status: UNKNOWN
Conditions: Secondary Hyperparathyroidism|Maintenance Hemodialysis
Interventions: PROCEDURE: microwave ablation|DRUG: active vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Pharmacokinetics of a Single Dose of UCB9741 in Healthy Caucasian and Japanese Participants
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: UCB9741|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effectiveness and Safety of Collagen Membrane (FormaAid®) in the Treatment of Periodontal Regeneration
Status: NOT_YET_RECRUITING
Conditions: Guided Tissue Regeneration|Collagen Membrane|Dental Diseases
Interventions: DEVICE: FormaAid|DEVICE: Bio-Gide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma|Ann Arbor Stage IV Childhood Non-Hodgkin Lymphoma|Ependymoma|Ewing Sarcoma|Hepatoblastoma|Langerhans Cell Histiocytosis|Malignant Germ Cell Tumor|Malignant Glioma|Osteosarcoma|Peripheral Primitive Neuroectodermal Tumor|Recurrent Childhood Central Nervous System Neoplasm|Recurrent Childhood Non-Hodgkin Lymphoma|Recurrent Malignant Solid Neoplasm|Recurrent Neuroblastoma|Refractory Malignant Solid Neoplasm|Refractory Neuroblastoma|Refractory Non-Hodgkin Lymphoma|Refractory Primary Central Nervous System Neoplasm|Rhabdoid Tumor|Rhabdomyosarcoma|Soft Tissue Sarcoma|Wilms Tumor
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MBI for Psychological Distress, SI and NSSI Among Young Adults
Status: COMPLETED
Conditions: Psychological Distress|Suicidal Ideation|Non-Suicidal Self Injury
Interventions: OTHER: Mindfulness Based Stress Reduction Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of Andrographolides Versus Placebo in Patients With Progressive Forms of MS
Status: UNKNOWN
Conditions: Primary Progressive Multiple Sclerosis|Multiple Sclerosis, Secondary Progressive
Interventions: DRUG: Andrographolides|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypocaloric Nutrition in Critically Ill Patients
Status: COMPLETED
Conditions: Critically Ill
Interventions: DIETARY_SUPPLEMENT: Hypocaloric hyperproteic nutrition|DIETARY_SUPPLEMENT: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Selenium and Arsenic Pharmacodynamics
Status: COMPLETED
Conditions: Arsenic Poisoning Chronic
Interventions: DIETARY_SUPPLEMENT: Anhydrous selenite|DIETARY_SUPPLEMENT: Sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The in Vivo Effect of Medical and Surgical Glaucoma Treatments on the Schlemm's Canal Micro-structure
Status: UNKNOWN
Conditions: Glaucoma|Cataract
Interventions: DEVICE: Optical coherence tomography imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Improvement of Myocardial Blood Flow by PhosphoDiesterase 5 Inhibition in Coronary Artery Disease
Status: TEMPORARILY_NOT_AVAILABLE
Conditions: Therapy Refractory Myocardial Ischemia|Coronary Artery Disease|Unsuitable for Surgical or Percutaneous Revascularisation
Interventions: DRUG: Vardenafil|OTHER: Placebo
Study Type: EXPANDED_ACCESS
Clinical trial: A Study to Find a Safe Dose of Volasertib Given in Addition to Standard Salvage Chemotherapy in Children (Age 3 Months to Less Than 18 Years) With Acute Myeloid Leukaemia, in Whom Front-line Chemotherapy Failed
Status: WITHDRAWN
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: Volasertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Timing of Implant Placement on Early Healing Molecular Events
Status: NOT_YET_RECRUITING
Conditions: Dental Implant|Healing Wound|Biomarkers|Saliva
Interventions: OTHER: Immediate implant placement and guided bone regeneration (Test)|OTHER: Late implant placement and guided bone regeneration (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Tolerability Study of Recombinant L-IFN Adenovirus Injection in Patients With Recurrent Glioblastoma
Status: RECRUITING
Conditions: Recurring Glioblastoma
Interventions: DRUG: Recombinant L-IFN adenovirus injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Administration of Edoxaban After Acute Ischemic Stroke in Patients With Non-valvular Atrial Fibrillation
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Edoxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study on Safety and Clinical Efficacy of AZVUDINE in COVID-19 Patients (SARS-CoV-2 Infected)
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: AZVUDINE|DRUG: AZVUDINE placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of Ganetespib +/- Bortezomib in Patients With Relapsed and/or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Ganetespib|DRUG: Bortezomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study to Assess the Effects of Almonertinib Following Chemoradiation in Patients With Stage III Unresectable Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Almonertinib|DRUG: Placebo Almonertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tocilizumab as Monotherapy and in Combination With Methotrexate Versus Methotrexate in Patients With Early Moderate to Severe Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tocilizumab|DRUG: Placebo to tocilizumab|DRUG: Methotrexate|DRUG: Placebo to methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Anesthesia on Tumor Immunity and Insulin Resistance During Perioperative Period
Status: COMPLETED
Conditions: Anesthesia|Cervical Cancer|Carbohydrate|Tumor Immunity
Interventions: OTHER: oral carbohydrate liquid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect on Exercise Endurance and Lung Hyperinflation of Tiotropium + Olodaterol in COPD Patients.
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Placebo|DRUG: Tiotropium + Olodaterol|DRUG: tiotropium + Olodaterol|DRUG: Tiotropium|DRUG: Olodaterol|DEVICE: Respimat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Fluency Stent-Graft Versus Luminex Stent for Angioplasty of Recurrent Stenosis of the Cephalic Arch in Autogenous Arteriovenous (AV) Access for Hemodialysis
Status: COMPLETED
Conditions: Stenosis
Interventions: DEVICE: Stent or stent-graft deployment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety in Patients With Chronic Lymphocytic Leukemia (CLL) Treated With Idelalisib and Rituximab in the Clinical Practice: a GIMEMA-ERIC Study
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: idelalisib and rituximab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Ginkgo (Gingko Biloba) on Retinal and Choroidal Ocular Tissue
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Gingko Biloba
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis
Status: COMPLETED
Conditions: Psoriasis|Atherosclerotic Cardiovascular Disease|Obesity|Dyslipidemia|Cardiometabolic Diseases
Interventions: DIETARY_SUPPLEMENT: Niagen|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Implementing an Intervention to Address Social Determinants of Health in Pediatric Practices
Status: COMPLETED
Conditions: Basic Unmet Material Needs|Patient Satisfaction|Receipt of Community Resources|Provider Referrals
Interventions: BEHAVIORAL: WE CARE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Feasibility of the JOIN4JOY Programme to Reduce Sedentary Behaviour and Increase Physical Activity in Older Adults.
Status: NOT_YET_RECRUITING
Conditions: Physical Inactivity|Sedentary Behavior
Interventions: OTHER: Complex intervention involving physical activity and behaviour change techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Versus Vaginal Cuff Closure During LH in Benign Gynecological Lesions
Status: RECRUITING
Conditions: Uterine Diseases
Interventions: PROCEDURE: Bakay purse string|PROCEDURE: Cuff closure via vaginal route group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of DWJ1248 in Prevention of COVID-19 Infection After the Exposure of SARS-COV-2
Status: TERMINATED
Conditions: Covid19|SARS-COV-2 Infection
Interventions: DRUG: DWJ1248|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Expanded Access Protocol (EAP) to Provide Bortezomib to Patients With Multiple Myeloma Who Have Received at Least 2 Previous Lines of Therapy and Are Refractory to or Have Relapsed After Their Last Therapy for Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib, tradename Velcade
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Investigate Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapagliflozin in Participants With Chronic Kidney Disease and High Proteinuria (ZENITH High Proteinuria)
Status: RECRUITING
Conditions: Chronic Kidney Disease With High Proteinuria
Interventions: DRUG: Zibotentan/Dapagliflozin|DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interleukin-12, Paclitaxel, and Trastuzumab in Treating Patients With Solid Tumors
Status: COMPLETED
Conditions: Male Breast Cancer|Recurrent Breast Cancer|Recurrent Endometrial Carcinoma|Recurrent Gastric Cancer|Recurrent Non-small Cell Lung Cancer|Recurrent Ovarian Epithelial Cancer|Recurrent Small Cell Lung Cancer
Interventions: BIOLOGICAL: trastuzumab|DRUG: paclitaxel|BIOLOGICAL: recombinant interleukin-12
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of EV71 Vaccine With or Without Aluminum Adjuvant in Infants
Status: WITHDRAWN
Conditions: Infection, Viral, Enterovirus
Interventions: BIOLOGICAL: 400 U EV71 vaccine with adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION