pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: First Time in Human Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and the Effect of Food of Single Assending Doses of GSK1482160.
Status: COMPLETED
Conditions: Pain, Inflammatory
Interventions: DRUG: GSK1482160 or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: "Pharmacodynamic Comparison of Omeprazole Versus Pantoprazole on Platelet Reactivity in Patients With Acute Coronary Syndromes on Dual Antiplatelet Therapy With New P2Y12 Inhibitors" -Trial dOPPLER-
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: Pantoprazole,|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aquatic and Land Physical Training Effects on Cardiometabolic Risk Factors in Adolescents With Overweight and Obesity
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: BEHAVIORAL: Jump exercise|BEHAVIORAL: Aquatic exercise|OTHER: Nutritional guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic of Lower Respiratory Tract Infection by Lung Ultrasonography in General Practice
Status: COMPLETED
Conditions: Lower Resp Tract Infection|Ultrasound Therapy; Complications
Interventions: DIAGNOSTIC_TEST: Lung ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Continuous Glucose Monitoring Devices in Hospitalized Veterans With Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Hypoglycemia
Interventions: DEVICE: GTS (Continuous Glucose Monitoring)|OTHER: POC (Point of Care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Safety and Effectiveness of Ganciclovir in the Prevention of Cytomegalovirus (CMV) of the Eyes and Disease of the Stomach and Intestines in Patients With HIV
Status: COMPLETED
Conditions: Cytomegalovirus Retinitis|HIV Infections|Gastrointestinal Diseases
Interventions: DRUG: Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Positive and Quantitative Diagnosis of Pleural Effusions by Thoracic Ultrasonography in Patients With Acute Respiratory Failure in the Emergency Department
Status: TERMINATED
Conditions: Pleural Effusion|Ultrasonography|Thoracic|Acute Respiratory Failure|Emergencies
Interventions: DEVICE: Ultrasonography thoracic
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Pharmacokinetics of Intravenous and Oral Posaconazole in Immunocompromised Children (MK-5592-097)
Status: COMPLETED
Conditions: Neutropenia
Interventions: DRUG: Posaconazole IV solution|DRUG: Posaconazole powder for oral suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of a Fall Preventive Exercise Program on Intrinsic Fall Risk Factors in Healthy Older Adults.
Status: COMPLETED
Conditions: Fall Risk Factors|Fall Prevention
Interventions: BEHAVIORAL: Exercise with supervision|BEHAVIORAL: Home-based without supervision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study of Eltrombopag 50 Milligram (mg) in Healthy Volunteers Under Fasting Conditions
Status: COMPLETED
Conditions: Cirrhosis, Liver
Interventions: DRUG: Eltrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Computerized Screening, Brief Intervention, and Referral to Treatment in Primary Care
Status: COMPLETED
Conditions: Substance Use Disorder
Interventions: BEHAVIORAL: Computerized brief intervention|BEHAVIORAL: Computerized health screening|BEHAVIORAL: Computerized assessment|BEHAVIORAL: Therapist-delivered motivational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Targeted Medical Therapy in Angina and Nonobstructive Coronary Arteries
Status: RECRUITING
Conditions: Angina Pectoris|Microvascular Angina|Vasospastic Angina|Myocardial Bridge of Coronary Artery
Interventions: DRUG: Amlodipine|DRUG: Nebivolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise Performance on Ambient Air vs. Low-Flow Oxygen Therapy in Pulmonary Vascular Disease (PVD)
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Vascular Disorder|Chronic Thromboembolic Pulmonary Hypertension|Pulmonary Arterial Hypertension
Interventions: OTHER: 6-minute walk distance (6MWD) test on ambient air|OTHER: 6-minute walk distance test with supplemental oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Results of Adjunctive Intraoperative Bevacizumab Injection on Trabeculectomy Outcome
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: Bevacizumab|DRUG: Mitomycin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Local Anaesthesia Technique on the Recovery After Dental Treatment in General Anaesthesia
Status: COMPLETED
Conditions: Postoperative Complications
Interventions: PROCEDURE: Extraction of teeth in general anaesthesia using either computer-controlled intraosseous anesthesia device or carpule for local anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Assessing the Safety and Efficacy of Subcutaneous RoActemra/Actemra Alone or in Combination With Non-biologic Antirheumatics in Rhuematoid Arthritis Patients in Latin America With Inadequate Response to Non-biologic Antirheumatic Drugs.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: tocilizumab [RoActemra/Actemra]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis
Status: RECRUITING
Conditions: Primary Myelofibrosis|Post-polycythemia Vera Myelofibrosis|Post-essential Thrombocythemia Myelofibrosis
Interventions: DRUG: Pacritinib|DRUG: Physician's Choice medications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Deucravacitinib Concentrations in the Breast Milk and Plasma of Healthy Lactating Female Participants
Status: NOT_YET_RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: Deucravacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diaphragm Plication in Adults With Phrenic Nerve Paralysis
Status: UNKNOWN
Conditions: Phrenic Nerve Paralysis
Interventions: PROCEDURE: diaphragm plication 6 months after inclusion|PROCEDURE: diaphragm plication at time of inclusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Open, Multicenter Clinical Trial of Eltrombopag Combined With Diacerein in Eltrombopag-inefficient or Relapsed ITP
Status: COMPLETED
Conditions: Thrombocytopenia
Interventions: DRUG: Eltrombopag and Diacerein
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of SST-0225 Topical Ibuprofen Cream in the Treatment of Delayed Onset Muscle Soreness (DOMS)
Status: COMPLETED
Conditions: Delayed Onset Muscle Soreness, DOMS
Interventions: DRUG: SST-0225|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Two Facial Sunscreens to Assess Its Effect in Improving Hydration, Skin Barrier Function, and Skin Tone Uniformity Under Controlled and Normal Conditions of Use on the Face by Adult Participants
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Sunscreen A|OTHER: Sunscreen B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 3, Vehicle-controlled Efficacy and Safety Study of IDP-123 Lotion in the Treatment of Acne Vulgaris (302)
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: IDP-123 Lotion|DRUG: IDP-123 Vehicle Lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Uterine Fibroid Embolization- Long Term Follow up and Technical Perspectives
Status: COMPLETED
Conditions: Uterine Fibroids|Arterial Embolization
Interventions: PROCEDURE: embolizations ,uterine fibroid|PROCEDURE: embolizations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation Examining Plaque and Gingivitis Connected Toothbrush Compared to Non-Connected Toothbrush
Status: COMPLETED
Conditions: Gingivitis|Plaque, Dental
Interventions: DEVICE: Electric Toothbrush|OTHER: oral health care application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Glycine "Deficiency" and the Kinetics of Acylglycine in Morbid Obesity
Status: UNKNOWN
Conditions: Morbid Obesity|Glycine; Metabolic Disorder
Interventions: DIETARY_SUPPLEMENT: Glycine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Nifedipine Versus Indomethacin in the Treatment of Preterm Labour
Status: UNKNOWN
Conditions: Obstetric Labor, Premature
Interventions: DRUG: Nifedipine|DRUG: Indomethacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Study to Evaluate the Efficacy of Insulclock® in Patients With Uncontrolled Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes
Interventions: DEVICE: Insulclock with feedback|DEVICE: Insulclock without feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Manganese-Enhanced MRI (MEMRI) to Assess Peri-Infarct Injury
Status: COMPLETED
Conditions: ISCHEMIC CARDIOMYOPATHY
Interventions: DRUG: Manganese-enhanced MRI contrast reagent|DRUG: Gadolinium-enhanced MRI contrast reagent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: C11-Sodium Acetate PET/CT Imaging Evaluation in Brain Glioma, Post Therapy Necrosis and Pseudo-progression
Status: WITHDRAWN
Conditions: Gliomas
Interventions: DRUG: Sodium Acetate C11 PET/CT Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Dose-Ranging Study of MK-5442 in Postmenopausal Women With Osteoporosis (MK-5442-001)
Status: TERMINATED
Conditions: Osteoporosis
Interventions: DRUG: MK-5442|DRUG: Placebo|DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Calcium carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of RAD001 and LBH589 in All Solid Tumors With Enrichment for EBV Driven Tumors
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma, Lymphomas, Any EBV+ Solid Tumour
Interventions: DRUG: LBH589 and RAD001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Femtolaser Assisted Keratoplasty Versus Conventional Keratoplasty
Status: UNKNOWN
Conditions: Keratoconus|Fuchs Dystrophy|Corneal Disease
Interventions: PROCEDURE: Femtosecond Laser|PROCEDURE: Trephine blade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Follow-up Study to Evaluate the Efficacy and Safety of ALLO-ASC-DFU in ALLO-ASC-EB-101 Clinical Trial
Status: COMPLETED
Conditions: Dystrophic Epidermolysis Bullosa
Interventions: BIOLOGICAL: ALLO-ASC-DFU
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Development of Virtual Reality-based Interventions to Strengthen Cognitive Skillsets Related to Attention Deficit Hyperactivity Disorder (ADHD): A Pilot Phase I and Randomized Controlled Phase II Trial
Status: RECRUITING
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: Floreo Virtual Reality application
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Use of a Probiotic Supplement in People With Long COVID
Status: RECRUITING
Conditions: Long COVID
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban
Status: TERMINATED
Conditions: Insomnia|Nicotine Dependence
Interventions: DRUG: Eszopiclone|DRUG: Bupropion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: New Infant Formula Trial in Healthy Term Subjects on Growth, Body Composition, Tolerance and Safety
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Test Product|OTHER: Control Product 1|OTHER: Control Product 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Impact of Roflumilast on Visceral Adiposity and Metabolic Profile in Chronic Obstructive Pulmonary Disease
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease|Metabolic Syndrome
Interventions: DRUG: Roflumilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Additive Anti-inflammatory Effect of Simvastatin in Combination With Inhaled Corticosteroids on p38 MAPK in Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Simvastatin|DRUG: B1-6-12
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of Autologous CD30.CAR-T in Relapsed or Refractory CD30 Positive Non-Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Anaplastic Large Cell Lymphoma|Peripheral T Cell Lymphoma|Extranodal NK/T-cell Lymphoma|Diffuse Large B Cell Lymphoma|Primary Mediastinal Large B-Cell Lymphoma (PMBCL)
Interventions: DRUG: CD30.CAR-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Clonal Dynamics During Venetoclax Treatment for Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: During Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Change of Tissue Oxygenation During a Vascular Occlusion Test Using Two Different NIRS (O3TM vs. INVOS®)
Status: COMPLETED
Conditions: Tissue Oxygen Saturation
Interventions: DEVICE: O3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: NaF PET/MRI Evaluation for Bone Metastases in Breast Cancer
Status: COMPLETED
Conditions: Malignant Neoplasm of Breast TNM Staging Distant Metastasis (M)|Untreated Bone Metastases
Interventions: DEVICE: NaF PET/MRI|DEVICE: NaF PET/CT|DEVICE: FDG PET/CT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Psychotherapy for PTSD Among Veterans Also Receiving Drug or Alcohol Treatment
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic|Substance Use Disorders
Interventions: BEHAVIORAL: Prolonged Exposure Therapy|BEHAVIORAL: Cognitive Processing Therapy|BEHAVIORAL: Present Centered Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of EndoClot™ Spraying After Endoscopic Resection of Large Colorectal Polyps
Status: TERMINATED
Conditions: Wound Endoscopical, Colon|After Polyp Resection, Colon
Interventions: PROCEDURE: use of EndoClot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: RM1 Project 1 - tAN Naloxone
Status: RECRUITING
Conditions: Analgesia
Interventions: DRUG: Naloxone|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Capecitabine, Oxaliplatin, and Gefitinib in Treating Patients With Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: capecitabine|DRUG: gefitinib|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: iCare4: Genomic Signatures With Midostaurin in Acute Myeloid Leukemia (UF-HEM-004)
Status: WITHDRAWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Midostaurin|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photobiomodulation Home-use Device for Prevention or Treatment of Oral Mucositis in Patients With Head&Neck Malignancies
Status: UNKNOWN
Conditions: Mucositis|Head and Neck Cancer|Radiotherapy Side Effect
Interventions: DEVICE: B-Cure laser pro
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Use of Botulinum Toxin in the Treatment of Itching From Hypertrophic Scar -- A Randomised Controlled Trial
Status: UNKNOWN
Conditions: Itchiness|Hypertrophic Scar|Botulinum Toxin
Interventions: DRUG: Botulinum Toxins|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Statin Treatment on Arterial Wall Inflammation as Assessed With 68Ga-DOTATATE PET-CT
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Vascular Inflammation
Interventions: DRUG: Atorvastatin 40 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: New Treatments for Actinic Keratoses of the Scalp
Status: ACTIVE_NOT_RECRUITING
Conditions: Photodamaged Skin|Actinic Keratoses
Interventions: DEVICE: Pulsed-dye laser|DEVICE: Fractional CO2-laser|DRUG: Metvix cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does the Harmonic Scalpel Reduce Blood Loss and OR Time in Major Head and Neck Cancer Surgery Undergoing Major Surgery for Oral Cavity Squamous Cell Carcinoma?
Status: COMPLETED
Conditions: Oral Cavity Squamous Cell Carcinoma, Treated With Surgery
Interventions: PROCEDURE: surgical resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Drug Levels, and Drug Effects of BMS-986326 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: BIOLOGICAL: BMS-986326|OTHER: Placebo matching BMS-986326|BIOLOGICAL: Multiple Ascending Dose SC|OTHER: Multiple Ascending Dose Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pioglitazone in Sporadic Inclusion Body Myositis
Status: COMPLETED
Conditions: Myositis|Inclusion Body Myositis|Muscular Diseases|Musculoskeletal Disease|Neuromuscular Diseases|Nervous System Diseases
Interventions: DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: One Stage Versus Two Stage For Periprosthetic Hip And Knee Infection
Status: ACTIVE_NOT_RECRUITING
Conditions: Surgical Site Infection
Interventions: PROCEDURE: One-stage exchange joint replacement surgery|PROCEDURE: Two-stage exchange joint replacement surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erythromycin Versus Azithromycin in Preterm Premature Rupture of Membranes
Status: WITHDRAWN
Conditions: Preterm Premature Ruptured Membranes
Interventions: DRUG: Azithromycin|DRUG: Erythromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Perioperative Management & Outcome Following Preoperative Transthoracic Echocardiography in Noncardiac Surgery Patients
Status: NOT_YET_RECRUITING
Conditions: Elective Surgical Procedure
Interventions: OTHER: Transthoracic Echocardiography Recieved
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence of Crushed Stribild With a Normal Breakfast or With Drip Feed Compared to the Whole Tablet
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Stribild|DRUG: Stribild, crushed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Dexmedetomidine on Postoperative Delirium After Awake Craniotomies
Status: RECRUITING
Conditions: Dexmedetomidine|Delirium|Awake Craniotomy
Interventions: DRUG: Dexmedetomidine|DRUG: 0.9% saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Male Involvement in Antenatal Care and the Prevention Programme of Mother-to-child Transmission of HIV in Uganda
Status: COMPLETED
Conditions: HIV Infection
Interventions: BEHAVIORAL: Invitation letter for male spouse|BEHAVIORAL: Information letter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Exploratory Regimen of Basiliximab for Treatment of Pulmonary Cytokine Storm in SARS-CoV-2 Hospitalized Adult Patients
Status: UNKNOWN
Conditions: SARS-CoV-2 Acute Respiratory Disease|SARS-CoV2 Infection|Cytokine Storm
Interventions: DRUG: Basiliximab Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Radiation Therapy in Treating Patients With Recurrent Primary Ovarian or Uterine Cancer
Status: COMPLETED
Conditions: Recurrent Endometrial Serous Adenocarcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Biological Function of Muscle Satellite Cells From Patients With Obstetric Brachial Plexus Palsy
Status: RECRUITING
Conditions: Obstetrical Brachial Plexus Palsy
Interventions: PROCEDURE: Muscle biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Fibrinolytic Therapy Versus Medical Thoracoscopy
Status: COMPLETED
Conditions: Pleural Diseases
Interventions: PROCEDURE: Chest thoracoscopy|PROCEDURE: Chest fibrinolytic therapy|DRUG: tPA|DRUG: DNase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The ONE Study nTreg Trial (ONEnTreg13)
Status: COMPLETED
Conditions: Immunosuppressive Treatment of Living-donor Renal Transplantation
Interventions: BIOLOGICAL: autologous CD4+CD25+FoxP3+ natural regulat. T cells (nTregs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Onvansertib in Combination With Abiraterone and Prednisone in Adult Patients With Metastatic Castration-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Metastatic Castration-Resistant Prostate Cancer
Interventions: DRUG: Onvansertib|DRUG: Abiraterone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydrus Microstent for Refractory Open-Angle Glaucoma
Status: COMPLETED
Conditions: Open-angle Glaucoma
Interventions: DEVICE: Hydrus Microstent|PROCEDURE: Ophthalmic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Efficacy of AI-Guided (GenAIS TM) vs. Standard Physician-Guided Dietary Supplement Prescriptions for Lowering LDL Cholesterol in Hypercholesterolemic Patients
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: OTHER: Standart supplementation therapy group|OTHER: AI-guided supplementation therapy group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improved Automatic CPAP Algorithm to Treat Obstructive Sleep Apnea (OSA)
Status: COMPLETED
Conditions: Obstructive Sleep Apnea (OSA)
Interventions: DEVICE: Modified AutoSet Algorithm|DEVICE: Standard AutoSet Algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Fluzone® Quadrivalent, Fluzone® Intradermal, and Fluzone® High-Dose, Influenza Vaccines in Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Fluzone® Quadrivalent vaccine, 2014-2015 formulation|BIOLOGICAL: Fluzone I®ntradermal vaccine, 2014-2015 formulation|BIOLOGICAL: Fluzone® Quadrivalent vaccine, 2014-2015 formulation|BIOLOGICAL: Fluzone High Dose vaccine, 2014-2015 formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cognitive-Behavior Therapy for Insomnia
Status: COMPLETED
Conditions: Chronic Insomnia
Interventions: OTHER: Cognitive-Behavior Therapy|OTHER: Behavior Therapy|OTHER: Cognitive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin
Status: UNKNOWN
Conditions: Cough
Interventions: DRUG: Guaiacol, eucalyptol, menthol and camphor suppository|DRUG: guaiacol suppository|DRUG: Guaifenesin syrup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coasting Versus Antagonist Protocol in Patients at High Risk of OHSS
Status: COMPLETED
Conditions: Ovarian Hyperstimulation Syndrome
Interventions: DRUG: Gonadotropin|DRUG: Antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of LW231 to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Volunteers and Participants With Chronic Hepatitis B Virus Infection
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Hepatitis B
Interventions: DRUG: LW231 tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Lifestyle Intervention Programme Using Mobile Application vs Booklet for Adult With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: OTHER: mobile application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Test the Long-term Safety, Tolerability and Efficacy of Brivaracetam in Study Participants 2 to 26 Years of Age With Childhood Absence Epilepsy or Juvenile Absence Epilepsy
Status: ENROLLING_BY_INVITATION
Conditions: Childhood Absence Epilepsy|Juvenile Absence Epilepsy
Interventions: DRUG: Brivaracetam Film-coated tablet|DRUG: Brivaracetam oral solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NASHA/Dx as a Perianal Implant for the Treatment of Persistent Fecal Incontience After Anorectal Malformation
Status: COMPLETED
Conditions: Fecal Incontinence|Anorectal Malformation
Interventions: DEVICE: NASHA/Dx (Solesta®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spinal Cord Stimulation (SCS) for Spinal Cord Injury (SCI)
Status: RECRUITING
Conditions: Spinal Cord Injury at T1-T12 Level|Traumatic Thoracic Spinal Cord Contusion|Thoracic Spinal Cord Trauma|Traumatic Thoracic Spinal Cord Laceration|Post-Traumatic Thoracic Myelopathy|Traumatic Thoracic Spinal Cord Myelopathy
Interventions: DEVICE: EES on|DEVICE: EES off
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Insulin Aspart in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin aspart|DRUG: human soluble insulin|DRUG: insulin NPH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bronchodilators for Wheeze in Young Children Presenting to Primary Care: a Randomised, Placebo-controlled, Multicentre, Parallel Group Trial
Status: WITHDRAWN
Conditions: Wheezing
Interventions: DRUG: Salbutamol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CGM/Clarity Use, Glycemic Control and Clinical Outcomes
Status: WITHDRAWN
Conditions: Diabetes Mellitus|Hyperglycemia|Hypoglycemia
Interventions: DEVICE: Continuous glucose Monitoring Devices and Clarity Software|OTHER: Point of Care (POC) blood glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy and Temsirolimus or Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: temozolomide|DRUG: temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05714 (Care Program)(P05715)
Status: COMPLETED
Conditions: Pregnancy|Neonates
Interventions: BIOLOGICAL: Corifollitropin alfa|BIOLOGICAL: GnRH antagonist|BIOLOGICAL: (rec)hCG|BIOLOGICAL: FSH|DRUG: Progesterone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Epidural Tap in Labor Analgesia FOR LABOR ANALGESIA
Status: COMPLETED
Conditions: Labor Pain
Interventions: DRUG: Dolantin|DRUG: Paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mogamulizumab Q4week Dosing in Participants With R/R CTCL
Status: ACTIVE_NOT_RECRUITING
Conditions: Cutaneous T-Cell Lymphoma, Relapsed|Cutaneous T-Cell Lymphoma Refractory
Interventions: DRUG: Mogamulizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deep Brain Stimulation (DBS) for the Management of Treatment Refractory Negative Symptoms in Schizophrenia
Status: WITHDRAWN
Conditions: Schizophrenia; Negative Type
Interventions: PROCEDURE: Deep Brain Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide With or Without Idelalisib in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Relapsed/Refractory Mantle Cell Lymphoma
Interventions: DRUG: lenalidomide|DRUG: idelalisib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Outcomes in Patients With Kidney Disease Due to Diabetes
Status: COMPLETED
Conditions: Diabetes|Kidney Disease|Hypertension
Interventions: DRUG: losartan 100 mg orally once daily|DRUG: spironolactone 25 mg orally once daily|DRUG: placebo once orally once daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Short Peptide Formula for Bowel Preparation
Status: COMPLETED
Conditions: Capsule Endoscopy|Pediatric Disorder
Interventions: OTHER: Short peptide|OTHER: Liquid diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Radiation Induced Pulmonary Hypertension Using MRI in Stage III NSCLC Patients Treated With Chemoradiotherapy. A Pilot Study
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: RADIATION: Cardiac Magnetic Resonance Imaging (MRI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Celecoxib and Recombinant Interferon Alfa-2b in Metastatic Kidney Cancer Who Have Undergone Surgery
Status: COMPLETED
Conditions: Renal Cell Cancer|Stage IV Renal Cell Cancer
Interventions: DRUG: celecoxib|BIOLOGICAL: recombinant interferon alfa-2b|OTHER: polymerase chain reaction|OTHER: laboratory biomarker analysis|OTHER: reverse transcriptase-polymerase chain reaction|OTHER: immunologic technique|OTHER: immunohistochemistry staining method|OTHER: flow cytometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palliative Radiotherapy to Dominant Symptomatic Lesion in Patients With Hormone Refractory Prostate Cancer
Status: UNKNOWN
Conditions: Hormone-refractory Prostate Cancer
Interventions: RADIATION: Palliative radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Acute L-NMMA Treatment on Renal Hemodynamics and Vasoactive Hormones in Patients With Congestive Heart Failure
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: DRUG: Ng-monomethyl-L-arginine (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose:
Clinical trial: Tolerability and Safety of Vemurafenib, Cetuximab Combined With Camrelizumab for BRAF V600E-mutated /MSS Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: BRAF V600E-mutated /MSS Metastatic Colorectal Cancer|Vemurafenib (BRAFi) Plus Cetuximab (EGFRi) Combined With PD-1 Monoclonal Antibody
Interventions: DRUG: Vemurafenib Oral Tablet [Zelboraf]|DRUG: Cetuximab Injection [Erbitux]|DRUG: Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery
Status: RECRUITING
Conditions: EKG-QT Prolongation
Interventions: DRUG: methadone|DRUG: Hydromorphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Low Versus Normal Flow Anesthesia on Cerebral Oxygenation and Bispectral Index in Morbidly Obese Patients
Status: COMPLETED
Conditions: Morbid Obesity|Anesthesia Awareness|Anesthesia Complication
Interventions: DEVICE: Regional cerebral oxygen saturation|DEVICE: Bispectral Index (BIS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Ultrasound-Guided Extrafascial Versus Intrafascial Interscalene Brachial Plexus Block in Shoulder Arthroscopy
Status: UNKNOWN
Conditions: Arthroscopy|Analgesia|Intrafascial Interscalene Brachial Plexus Block
Interventions: PROCEDURE: Intrafascial interscalene brachial plexus block|PROCEDURE: Extrafascial interscalene brachial plexus block group|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Soft Tissue Vibration in Reducing Pain of Local Anesthesia Injection in Adult Dental Patients
Status: COMPLETED
Conditions: Anesthetics, Local
Interventions: DEVICE: DentalVibe® Comfort Injection System|DRUG: Lidocaine Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dolutegravir + Rilpivirine Switch Study (DORISS)
Status: WITHDRAWN
Conditions: HIV Infection|HAART-treated|Virologically Controlled
Interventions: DRUG: Arm 1 (intervention)|DRUG: Arm 2 (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Using 3D Printed PEEK Facial Implants in Repairing Maxillofacial Deformities
Status: COMPLETED
Conditions: Maxillofacial Trauma|Face Cancer|Mucormycosis
Interventions: PROCEDURE: 3D printed polyether ether ketone facial implants in repairing maxillofacial deformities
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Anterior Vertebral Body Tethering (AVBT) Using Zimmer Biomet Tether System or Dynesys System Components to Treat Pediatric Scoliosis
Status: ENROLLING_BY_INVITATION
Conditions: Scoliosis
Interventions: DEVICE: AVBT using Dynesys System Components|PROCEDURE: Spine fusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bevacizumab and Gemcitabine in Treating Patients With Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage III Pancreatic Cancer|Stage IV Pancreatic Cancer
Interventions: DRUG: gemcitabine hydrochloride|BIOLOGICAL: bevacizumab|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Probiotic Supplement on Symptoms of Attention Deficit Hyperactivity Disorder and Anxiety in Children
Status: UNKNOWN
Conditions: Attention Deficit Hyperactivity Disorder|Anxiety
Interventions: DIETARY_SUPPLEMENT: L. helveticus R0052 and B. longum R0175|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A B-D-Glucan Driven Antifungal Stewardship Approach for Invasive Candidiasis
Status: TERMINATED
Conditions: Invasive Candidiases|Abdominal Infection
Interventions: DIAGNOSTIC_TEST: De-escalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate Efficacy, Safety, Tolerability and Pharmacokinetics of AZD1386 in Patients With Peripheral Neuropathic Pain
Status: TERMINATED
Conditions: Pain|Neuropathic Pain
Interventions: DRUG: AZD1386|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neuroimaging Biomarkers Toward a Personalized Upper Limb Action Observation Treatment in Chronic Stroke Patients
Status: UNKNOWN
Conditions: Chronic Stroke
Interventions: OTHER: Action Observation Treatrment|OTHER: Observation of videos with Non Motor contents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Genes That Affect Disease Progression in Women With Newly Diagnosed or Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: GENETIC: microarray analysis|GENETIC: polymerase chain reaction|GENETIC: polymorphism analysis|OTHER: high performance liquid chromatography|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|OTHER: questionnaire administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Apatinib Tablets in the Treatment of Advanced or Metastatic Gastric Cancer
Status: COMPLETED
Conditions: Advanced Gastric or Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: ApatinibTablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early vs Late Introduction of Antiretroviral Therapy in HIV-infected Patients With Tuberculosis (ANRS 1295 CAMELIA)
Status: COMPLETED
Conditions: HIV Infection|Tuberculosis
Interventions: PROCEDURE: Early antiretroviral treatment|PROCEDURE: Late antiretroviral treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy and Safety of PRT-2761 for the Treatment of Acute and Chronic Allergic Conjunctivitis
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: PRT-2761 0.5%|DRUG: PRT-2761 1%|DRUG: Patanol|DRUG: Pred-forte|DRUG: PRT-2761 0%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biosimilar Study Comparing PK, PD, Safety and Immunogencity of BP11 With US Licensed Xolair and EU Approved Xolair
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Omalizumab Prefilled Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Nicotinic Treatment of Post-Chemotherapy Subjective Cognitive Impairment: A Pilot Study
Status: COMPLETED
Conditions: Chemo Brain|Chemotherapy-related Cognitive Impairment|Chemo Fog|Breast Cancer|Chemobrain
Interventions: DRUG: Transdermal nicotine|OTHER: Placebo Transdermal Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Appearance and Disappearance of ASP3652 in Blood and Spinal Fluid in Healthy Male Subjects
Status: COMPLETED
Conditions: Pharmacokinetics of ASP3652|Pharmacodynamics of ASP3652|Healthy Subjects
Interventions: DRUG: ASP3652
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: QuantiFERON®-TB Gold In-Tube for the Diagnosis of Tuberculosis Infection in Contact Tracing Study.
Status: COMPLETED
Conditions: Latent Tuberculosis Infection
Interventions: DRUG: Preventive treatment with Isoniazid.|DRUG: Preventive treatment with Isoniazid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Investigation of Melatonin and Zolpidem Effect on Postural Instability in Healthy Adult Subjects
Status: COMPLETED
Conditions: Postural Instability
Interventions: DRUG: Circadin (R) 2 mg|DRUG: Stilnox (R) 10 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: