pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: OTO-413 in Subjects With Speech-in-Noise Hearing Impairment
Status: COMPLETED
Conditions: Sensorineural Hearing Loss
Interventions: DRUG: OTO-413|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Methadone vs. Fentanyl Administration on Postoperative Pain Control in Pediatric Patients Undergoing Cardiac Surgery
Status: TERMINATED
Conditions: Opioid Use, Unspecified
Interventions: DRUG: Methadone|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Soy Isoflavones Supplementation in Treating Women at High Risk For or With Breast Cancer
Status: COMPLETED
Conditions: BRCA1 Mutation Carrier|BRCA2 Mutation Carrier|Ductal Breast Carcinoma in Situ|Lobular Breast Carcinoma in Situ|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer
Interventions: DIETARY_SUPPLEMENT: soy isoflavones|OTHER: placebo|OTHER: questionnaire administration|PROCEDURE: magnetic resonance imaging|PROCEDURE: biopsy|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|PROCEDURE: mammography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Myelodysplastic Syndromes Comparing Hydralazine/Ac. Valproic and Supportive Care in Patients Not Candidates, Refractory and/or Intolerant to Intensive Chemotherapy
Status: UNKNOWN
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: BSC|DRUG: HIDRA/VPA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy of Paracetamol and Ibuprofen in the Management of Fever in Sepsis Patients
Status: RECRUITING
Conditions: Sepsis|Acetaminophen|Fever|Ibuprofen
Interventions: DRUG: Acetaminophen|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Measuring Head Control Change With 2D Video Analysis After Utilization of Headpod in Children With Poor Head Control
Status: COMPLETED
Conditions: To Determine Efficacy of the Headpod|Cerebral Palsy
Interventions: DEVICE: Headpod
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Food-effect Study of Abiraterone Acetate (AA) in Castration Resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: AA Reduced dose-normal diet (A)|DRUG: AA reduced dose-fat diet (B)|DRUG: AA normal dose-fasting conditions (C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Therapy in Dual Diagnosis Bipolar Rapid Cycling
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Divalproex|DRUG: Lamotrigine|DRUG: Lithium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Antihypertensive Effect of Continuous Positive Airway Pressure in Resistant Hypertensive Patients With Sleep Apnea
Status: COMPLETED
Conditions: Hypertension
Interventions: DEVICE: active CPAP|DEVICE: sham-CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Regulation of HIIT Combined With IET on Vascular Function in Young Women With Normal Weight Obesity
Status: COMPLETED
Conditions: Normal Weight Obesity
Interventions: BEHAVIORAL: HIIT|BEHAVIORAL: HIIT combined IET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Evaluate Safety and Efficacy of a Radiofrequency Renal Denervation System in Treatment of Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DEVICE: Renal Artery Radiofrequency Ablation System (Generator and Catheter )|DRUG: Antihypertensive Agents|DEVICE: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot - Peri-operative Beta Blockade
Status: COMPLETED
Conditions: Adrenergic Beta-Receptor Blockader|Troponin Levels|Cardiomyopathy, Post-surgical
Interventions: DRUG: metoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vaginal Estradiol Use in Pessary Care
Status: TERMINATED
Conditions: Pelvic Organ Prolapse|Urinary Incontinence|Pessary Ulcer of Vagina|Vaginal Atrophy
Interventions: DRUG: Estradiol vaginal cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Evaluation of Visco-Assisted CyPass® Micro-Stent Implantation in Patients With Open Angle Glaucoma
Status: COMPLETED
Conditions: Open Angle Glaucoma
Interventions: DEVICE: CyPass Micro-Stent|DEVICE: Viscoelastic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Folinic Acid: Supplementation and Therapy
Status: COMPLETED
Conditions: HIV Infection|HCV Coinfection
Interventions: DRUG: Folinic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Thoracic Paravertebral Block Combined With S-ketamine on Postoperative Pain and Cognitive Function After Thoracoscopic Surgery
Status: COMPLETED
Conditions: Postoperative Cognitive Dysfunction
Interventions: PROCEDURE: Thoracic paravertebral block|DRUG: Esketamine|BEHAVIORAL: Measurement of cognitive function|BEHAVIORAL: The assessment of cognitive function
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Bismuth-containing Quadruple Therapy for Helicobacter Pylori First-line Treatment of Different Tetracycline Doses
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Amoxicillin|DRUG: Tetracycline tid|DRUG: Tetracycline qid|DRUG: Bismuth Potassium Citrate|DRUG: Colloidal Bismuth Pectin|DRUG: Esomeprazole 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ConquerFear-Group: A Psychological Intervention for Fear of Cancer Recurrence
Status: COMPLETED
Conditions: Fear of Cancer Recurrence|Breast Cancer Female
Interventions: BEHAVIORAL: ConquerFear-Group|BEHAVIORAL: Relaxation Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Study of Intra-articular AMB-05X Injections in Subjects With Tenosynovial Giant Cell Tumor of the Knee
Status: COMPLETED
Conditions: Tenosynovial Giant Cell Tumor|Pigmented Villonodular Synovitis (PVNS)
Interventions: BIOLOGICAL: AMB-05X
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medical Optimization of Management of Type 2 Diabetes Complicating Pregnancy (MOMPOD)
Status: TERMINATED
Conditions: Diabetes|Pregnancy
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Perceptive, Executive and Emotional Factors on Decision-making of Pedestrian Face to Autonomous Vehicles.
Status: RECRUITING
Conditions: Decision-making
Interventions: OTHER: neurocognitifs tests + pedestrian crossign whith virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Modulation of Sensory Acuity With Transcranial Magnetic Stimulation (TMS)
Status: COMPLETED
Conditions: Speech
Interventions: DEVICE: TMS|BEHAVIORAL: somatosensory acuity measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate Efficacy of CO-1.01 as Second Line Therapy for Gemcitabine-Refractory Stage IV Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: CO-1.01
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Use of Respiratory Devices After Thoracic Surgery
Status: COMPLETED
Conditions: Dyspnea|Well Being
Interventions: DEVICE: Combined use of RESPIVOL® and RESPILIFT®|DEVICE: Combined use of RESPIVOL® and RESPILIFT®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Neuromuscular Blockade and Reversal on Breathing
Status: COMPLETED
Conditions: Respiratory Insufficiency
Interventions: DRUG: Sugammadex|DRUG: Neostigmine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thermal Radiofrequency Versus Neurolytic Saddle Rhizotomyfor Severe Pereneal Cancer Pain
Status: UNKNOWN
Conditions: Interactable Malignant Perineal Pain
Interventions: PROCEDURE: Thermal radio Frequency, selective (unilateral S3, bilateral S4 and S5) saddle rhizotomy|DRUG: hyperbaric chemical saddle Rhizotomy (6 % pherol in glycerin)|DEVICE: Thermal RF lesioning is done using Bailys RF generator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Air-stacking on Peak Cough Flow in Patients With Acute Cervical or High Thoracic Spinal Cord Injury
Status: WITHDRAWN
Conditions: Spinal Cord Injury|Tetraplegia
Interventions: PROCEDURE: Air-stacking with a manual resuscitator|PROCEDURE: Air-stacking with ventilator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Exercise Intervention and Rehabilitation Exercise Intervention in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Non-Insulin-Dependent
Interventions: OTHER: rehabilitation exercise intervention|OTHER: placebo control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Development and Test of a Communication Skills Training for Transplant Providers - Aims 2 & 3
Status: NOT_YET_RECRUITING
Conditions: Kidney Disease, Chronic|End Stage Renal Disease|Kidney Replacement
Interventions: BEHAVIORAL: EPPComm Provider Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Efficacy of Acupuncture as a Complementary Treatment for Pain and Anxiety After Breast Cancer Surgery
Status: UNKNOWN
Conditions: Acupuncture Therapy|Breast Neoplasms
Interventions: OTHER: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation Strategies for a Simple Intervention to Reduce Longterm Benzodiazepine Use in Dutch Community Pharmacies
Status: COMPLETED
Conditions: Benzodiazepines Therapeutic Use
Interventions: BEHAVIORAL: training and follow-up of pharmacists|BEHAVIORAL: patient-directed discontinuation letter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Phase Ib/II Study of SHR-8068 Injection in the Treatment of Advanced Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Advanced Non-small Cell Lung Cancer
Interventions: DRUG: SHR-8068；Adebrelimab|DRUG: SHR-8068；adebrelimab and platinum-based chemotherapy|DRUG: Adebrelimab；platinum-based chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Daclatasvir, Sofosbuvir, and Ribavirin in Cirrhotic Participants and Participants Post-liver Transplant
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Daclatasvir|DRUG: Sofosbuvir|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VEin of MArshall Ethanolization vs Extended Pulmonary Vein PULSEd Field Ablation After Failed PVI for Persistent AF
Status: NOT_YET_RECRUITING
Conditions: Persistent Atrial Fibrillation
Interventions: PROCEDURE: Pulsed field ablation with posterior wall isolation|PROCEDURE: Radiofrequency ablation and vein of Marshall ethanolization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neurophysiological Dissection and Intervention of Freezing of Gait in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson's Disease With Freezing of Gait
Interventions: DEVICE: Transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Radiation in Treating Patients With Stage III or IV Head and Neck Cancer (Paradigm Trial)
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: carboplatin|DRUG: cisplatin|DRUG: docetaxel|DRUG: fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of GNC-035, a Tetra-specific Antibody, in Participants With Relapsed/Refractory Hematologic Malignancy
Status: RECRUITING
Conditions: Hematologic Malignancies
Interventions: DRUG: GNC-035
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Approach Open Label Study: A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Participants With Familial Chylomicronemia Syndrome
Status: COMPLETED
Conditions: Familial Chylomicronemia Syndrome|Lipoprotein Lipase Deficiency|Hyperlipoproteinemia Type 1
Interventions: DRUG: Volanesorsen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Vacuum-Assisted Percutaneous Excision to Open Surgical Excision for Borderline or High-Risk Breast Lesions
Status: NOT_YET_RECRUITING
Conditions: Breast Fibroadenoma|Atypical Ductal Hyperplasia|Atypical Lobular Hyperplasia|Lobular Carcinoma in Situ|Flat Epithelial Atypia|Phyllodes; Fibroadenoma|Phyllodes Breast Tumor|Radial Scar|Breast Papilloma|Complex Sclerosing Papillary Lesion of the Breast
Interventions: PROCEDURE: Vacuum-assisted percutaneous excision|PROCEDURE: Open surgical excision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Rucaparib Administered With Radiation in Patients With Triple Negative Breast Cancer With an Incomplete Response Following Chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Rucaparib|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Respiratory Muscle Strength Training in Presbyphonia
Status: COMPLETED
Conditions: Presbylarynx
Interventions: DEVICE: Inspiratory Muscle Strength Training (IMST)|DEVICE: Expiratory Muscle Strength Training (EMST)|BEHAVIORAL: Voice Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Home Treatment of HIV-Infected Patients With Interleukin-2 With or Without a Tumor Necrosis Factor Antagonist
Status: COMPLETED
Conditions: Acquired Immunodeficiency Syndrome|HIV Infection
Interventions: DRUG: IL-2 plus Anti-TNF or Thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Cardiac RADIoablation Versus Repeat Catheter Ablation: a Pivotal Randomized Clinical Trial Evaluating Safety and Efficacy for Patients With High-risk Refractory Ventricular Tachycardia (RADIATE-VT)
Status: RECRUITING
Conditions: Tachycardia, Ventricular
Interventions: DEVICE: Varian Cardiac Radioablation (CRA)|PROCEDURE: Catheter Ablation (CA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bivalirudin With Prolonged Full Dose Infusion Versus Heparin Alone During Emergency PCI
Status: UNKNOWN
Conditions: ST Elevation Myocardial Infarction
Interventions: DRUG: Bivalirudin|DRUG: unfractionated Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Bromfenac Ophthalmic Solution
Status: COMPLETED
Conditions: Cataract Surgery
Interventions: DRUG: bromfenac ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MRA Therapy Versus CPAP Therapy in Moderate OSAS
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DEVICE: mandibular repositioning appliance (MRA) (SomnoDent)|PROCEDURE: Continuous positive airway pressure (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of MB-6 Plus FOLFOX4 for Metastatic Colorectal Cancer (FDA IND 103675)
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: MB-6|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety and Efficacy Study of Adalimumab in Pediatric Subjects With Ulcerative Colitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Ulcerative Colitis
Interventions: BIOLOGICAL: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRISM Study-Pruritus Relief Through Itch Scratch Modulation
Status: COMPLETED
Conditions: Prurigo Nodularis
Interventions: DRUG: Nalbuphine ER Tablets|OTHER: Matching Placebo Tablets|DRUG: Nalbuphine ER Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Participants With Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Advanced Non-Small Cell Lung Cancer
Interventions: DRUG: Pemetrexed|DRUG: Carboplatin|DRUG: Paclitaxel|BIOLOGICAL: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparisons of Metabolic Effect of Sleeve Gastrectomy With Duodenojejunal Bypass and Sleeve Gastrectomy (MEDUSA): A Multicenter Randomized Controlled Trial
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Bariatric Surgery|Surgical Procedures, Operative|Asians
Interventions: PROCEDURE: Duodenojejunal bypass|PROCEDURE: Sleeve gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microneedling With Regular Insulin Versus Microneedling Alone in Treatment of Atrophic Scars
Status: RECRUITING
Conditions: Scars|Insulin
Interventions: OTHER: Microneedling with topical application of regular insulin|OTHER: Microneedling with topical application of saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Gene Therapy Study for Homozygous Familial Hypercholesterolemia (HoFH)
Status: TERMINATED
Conditions: Homozygous Familial Hypercholesterolemia (HoFH)
Interventions: GENETIC: AAV directed hLDLR gene therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapy of HES, PV, Atypical Chronic Myelocytic Leukemia (CML) or Chronic Myelomonocytic Leukemia (CMML), and Mastocytosis With Imatinib Mesylate
Status: COMPLETED
Conditions: Chronic Myelomonocytic Leukemia|Chronic Myeloid Leukemia|Polycythemia Vera|Hypereosinophilic Syndrome|Mastocytosis
Interventions: DRUG: Imatinib Mesylate (Gleevec)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Saccharomyces Boulardii as Pretreatment Before Rescue Therapy of Helicobacter Pylori
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Saccharomyces Boulardii 250 MG|DRUG: Ilaprazole.Doxycycline. Furazolidone. Colloidal Bismuth Tartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Antidepressants on Sex Hormone Levels and Sexual Functioning
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Fluoxetine|DRUG: Bupropion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Research Study to Look at How Well Cagrilintide Together With Semaglutide Works in People With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide 2.4 mg|DRUG: Cagrilintide 2.4 mg|DRUG: Placebo (semaglutide)|DRUG: Placebo (cagrilintide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase IIa Study of Ublituximab in Participants With Relapsing Forms of Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BIOLOGICAL: Ublituximab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Cilengitide in Treating Patients With Unresectable or Metastatic Melanoma
Status: TERMINATED
Conditions: Stage III Melanoma|Stage IV Melanoma
Interventions: DRUG: cilengitide|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Fludarabine Combined With Either Alemtuzumab or Rituximab in Treating Patients With Refractory or Relapsed B-Cell Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: alemtuzumab|BIOLOGICAL: rituximab|DRUG: fludarabine phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erlotinib as First-line Treatment of Advanced Non-small Cell Lung Cancer (NSCLC) for Patients Unfit for Chemotherapy
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Label Phase II Study Combining Nivolumab and Celecoxib in Patients With Advanced " Cold " Solid Tumors
Status: UNKNOWN
Conditions: Metastatic Cancer
Interventions: DRUG: Celecoxib 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changing of Dressing for Periprosthetic Joint Infection in Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Infection|Surgical Site Infection|Prosthetic Infection|Wound Infection
Interventions: PROCEDURE: Regularly changing of dressing|PROCEDURE: No application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of the Beta-blocker Nebivolol (Bystolic) on Subjects With High Normal Blood Pressure and/or a Family History of Hypertension
Status: COMPLETED
Conditions: Pre-hypertension|Hypertension
Interventions: DRUG: Nebivolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Iron Absorption From Extruded FePP-fortified Rice Containing Zinc, Citric Acid/Trisodium Citrate and EDTA
Status: COMPLETED
Conditions: Iron Deficiency and/or Anemia
Interventions: OTHER: Ferric Pyrophosphate and Zinc Oxide|OTHER: Ferric Pyrophosphate and Zinc Sulphate|OTHER: Ferric Pyrophosphate, ZnO, Citric Acid and Trisodium Citrate|OTHER: Ferric Pyrophosphate, ZnSO4, CA/TSC|OTHER: Ferric Pyrophosphate, ZnO, CA, EDTA|OTHER: Ferrous Sulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Dedicated MR Imaging vs Surgical Staging of Peritoneal Carcinomatosis in Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer|Peritoneal Carcinomatosis|MRI
Interventions: DIAGNOSTIC_TEST: DWI MRI of the pelvis, abdomen and thorax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Dose Ascending Study of Gemcitabine Elaidate (CO-101) in Combination With Cisplatin
Status: TERMINATED
Conditions: Solid Tumor|Non-small-cell Lung Cancer|Lung Cancer
Interventions: DRUG: CO-1.01 and Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Thrust Versus Non-Thrust Thoracic Manipulation on Mechanical Neck Pain.
Status: UNKNOWN
Conditions: Neck Pain
Interventions: PROCEDURE: Thrust Manipulation|PROCEDURE: Non-Thrust manipulation|PROCEDURE: Standard Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Videoconferencing Between Ambulances and Physician Manned Rapid Response Vehicles, Effects on On-site Patient Treatment and Patterns of Referral
Status: WITHDRAWN
Conditions: All Acutely Ill or Injured Patients Receiving Care by Ambulance Personnel
Interventions: DEVICE: iPad air with 4G/3G SIM card
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Ongoing Pregnancy Rate Between Cleavage Stage and Early Compacting Embryo Transfer at 66±2 Hours After ICSI Using Single Step Culture Medium
Status: UNKNOWN
Conditions: Infertility
Interventions: OTHER: Compacting embryo transferring|OTHER: Non- compacting embryo transferring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Optimization of Antiemetic Regimen for C-RINV in LA-HNSCCs
Status: UNKNOWN
Conditions: Nausea|Vomiting|Head and Neck Squamous Cell Carcinoma|Radiotherapy Side Effect
Interventions: DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Mesalamine to Prevent Colitis Following Treatment With Ipilimumab/Nivolumab (Ipi/Nivo)
Status: NOT_YET_RECRUITING
Conditions: Immune-related Adverse Event|Diarrhea|Advanced Melanoma|Advanced Rectal Carcinoma
Interventions: DRUG: Mesalamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Hematopoietic Stem Cell-containing Autologous Blood Transfusion for Bone Marrow Protection in Patients With Cervical Cancer
Status: RECRUITING
Conditions: Cervical Cancer
Interventions: OTHER: Autologous blood transfusion with haematopoietic stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Controlled Clinical Trial of Antiviral Cytotoxic T Lymphocyte (CTL) Infusion Following Combination Antiretroviral Drug Therapy for Asymptomatic HIV-1 Infection
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: Indinavir sulfate|DRUG: Diphenhydramine hydrochloride|DRUG: Lymphocytes, Activated|DRUG: Lamivudine|DRUG: Zidovudine|DRUG: Acetaminophen|DRUG: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Different Adjunctive Plaque Control Modalities in Orthodontic Patients
Status: COMPLETED
Conditions: Gingivitis
Interventions: DEVICE: interdental brush|DEVICE: single tufted brush|DEVICE: water irrigator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of LY3540378 in Participants With Worsening Chronic Heart Failure With Preserved Ejection Fraction (HFpEF)
Status: RECRUITING
Conditions: Heart Failure|Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: LY3540378|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Computerized Antibiotic Stewardship Study
Status: COMPLETED
Conditions: Communicable Diseases
Interventions: OTHER: Computerized decision support and audit & feedback|OTHER: Audit & Feedback|OTHER: Standard antibiotic stewardship
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase3 Study to Evaluate the Efficacy and Safety of MEDI3250 in Healthy Japanese Children Age 7 Years Through 18 Years
Status: COMPLETED
Conditions: Healthy Japanese Children Age 7 Years Through 18 Years
Interventions: DRUG: MEDI3250|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Neurophysiological Response to Foodstuffs
Status: COMPLETED
Conditions: Healthy Nutrition
Interventions: OTHER: Bitter taste perception|OTHER: Salty taste perception|OTHER: Sweet taste perception|OTHER: Acid taste perception|OTHER: Umami taste perception
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Vaccine Therapy, Incomplete Freund's Adjuvant, and GM-CSF in Treating Patients With HIV
Status: COMPLETED
Conditions: Nonneoplastic Condition
Interventions: BIOLOGICAL: E1M184V peptide vaccine|BIOLOGICAL: incomplete Freund's adjuvant|BIOLOGICAL: sargramostim|OTHER: immunoenzyme technique
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block in Lumbar Spinal Fusion
Status: RECRUITING
Conditions: Lumbar Spinal Fusion
Interventions: PROCEDURE: Erector spinae plane block|PROCEDURE: Erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Esketamine and Fentanyl for Pain in Minor Trauma
Status: UNKNOWN
Conditions: Acute Pain Due to Trauma
Interventions: DRUG: Esketamine|DRUG: Fentanyl Citrate|DRUG: Saline Nasal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lidocaine Patches for Attenuating the Pain of Venipuncture Intravenous Cannulation
Status: UNKNOWN
Conditions: We Focus on the Pain of Venipuncture and Intravenous Cannulation
Interventions: DRUG: Lidocaine Patches
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Liquid Biopsy in Ewing Sarcoma and Osteosarcoma as a Prognostic And Response Diagnostic: LEOPARD
Status: RECRUITING
Conditions: Ewing Sarcoma|Ewing Sarcoma of Bone|Ewing Sarcoma of Soft Tissue|Peripheral Primitive Neuroectodermal Tumor|Peripheral Primitive Neuroectodermal Tumor of Bone|Peripheral Primitive Neuroectodermal Tumor of Soft Tissue|High-grade Osteosarcoma
Interventions: OTHER: FoundationOne Liquid CDx
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy Study Adding GSK2190915 to Mid-dose Inhaled Corticosteroid/Long Acting Beta Agonist Combination Treatment for Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: FP/SAL 250/50mcg BID|DRUG: GSK2190915 200mg QD (AM)|DRUG: GSK2190915 100mg QD (AM)|DRUG: Montelukast 10mg QD (PM)|DRUG: Placebo tablets (2) (AM)|DRUG: Placebo capsule (PM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Erlotinib Plus Docetaxel in Treating Patients With Stage IV or Recurrent Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: docetaxel|DRUG: erlotinib hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of and Immune Response to the Human Papillomavirus (HPV) Vaccine in HIV-Infected Women
Status: COMPLETED
Conditions: HIV Infections|Sexually Transmitted Diseases
Interventions: BIOLOGICAL: Quadrivalent HPV vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: BGS649 Monotherapy in Moderate to Severe Endometriosis Patients
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: Active treatment with a high dose of BGS649|DRUG: Active treatment with a low dose of BGS649|DRUG: Placebo treatment to blind study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Correction for Kyphotic Posture for Improving Balance in Cerebral Palsy
Status: COMPLETED
Conditions: Kyphosis
Interventions: OTHER: Conventional Physical Therapy Protocol|OTHER: TheraTog orthotic undergarment with its strapping system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Concentration of Budesonide in Breast Milk From Asthmatic Women
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Pulmicort (budesonide) Turbuhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Healthy Volunteer Study of the Pharmacokinetics of Oral Piperaquine With OZ439 + TPGS Formulation in the Fasted State
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: PQP tablets 960mg|DRUG: PQP tablets 1440mg|DRUG: OZ439+TPGS 800mg|DRUG: OZ439 PIB 800mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Accurate Diagnosis and Treatment of Peutz-Jeghers Syndrome
Status: UNKNOWN
Conditions: Peutz-Jeghers Syndrome
Interventions: BEHAVIORAL: Second generation sequencing|BEHAVIORAL: 16s rRNA gene sequencing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Food Effect Study of 60mg ER Torsemide
Status: COMPLETED
Conditions: Food-drug Interaction
Interventions: DRUG: Fed- 60mg ER Torsemide|DRUG: Fasting- 60mg ER Torsemide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Pigment-free Optical Zone Diameter of Decorative Tinted Soft Contact Lenses on Visual Function
Status: COMPLETED
Conditions: Tinted Contact Lense
Interventions: DEVICE: EyeLIKe Callamatch II, Koryo Eyetech Co, Seoul, Korea|DEVICE: EyeLIKe Shine, Koryo Eyetech Co
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy of the Integration of Digital Therapeutics and Home-based Cardiac Rehabilitation in High-Risk Post-PCI Patients
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease|Myocardial Infarction
Interventions: OTHER: DTx-guided HBCR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy and Safety of Non-resistance Manual Therapy in Inpatients With Acute Neck Pain Caused by Traffic Accidents: a Randomised Controlled Trial
Status: COMPLETED
Conditions: Whiplash Injury of Cervical Spine
Interventions: OTHER: non-resistance therapy|OTHER: acupuncture|OTHER: chuna|OTHER: pharmacoacupuncture|DRUG: Korean herbal medicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Drug-drug Interactions Between ACT-541468 and Ethanol in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ACT-541468|OTHER: ACT-541468 placebo|OTHER: Ethanol 10%|OTHER: Ethanol placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Ceftriaxone Vs Levofloxacin on Cytokine Expression in Pneumococcal Pneumonia
Status: TERMINATED
Conditions: Pneumonia, Pneumococcal
Interventions: DRUG: levofloxacin|DRUG: ceftriaxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of Sun Protection in Sunscreen Formulas (Study SR09-15)(P08236)(COMPLETED)
Status: COMPLETED
Conditions: Sun Protection
Interventions: DRUG: Sunscreen Test Code: V53-028|DRUG: Sunscreen Test Code: V53-030|DRUG: Standard SPF 4 Sunscreen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Manipulation of Dietary Protein and the Anabolic Response
Status: COMPLETED
Conditions: Focus: Anabolic Response to Food Intake in Young Individuals|Condition Relevance: Skeletal Muscle Health, Sarcopenia
Interventions: DIETARY_SUPPLEMENT: High protein intake|OTHER: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: MRI Hippocampal Microstructure and Episodic Memory in Early Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: OTHER: Clinical assessment|OTHER: Neuropsychological evaluation|OTHER: Psychological evaluation|DEVICE: MRI Evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Biomarker Study of Chemotherapy Resistance and Outcomes in Samples From Older Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: GENETIC: DNA methylation analysis|GENETIC: RNA analysis|GENETIC: gene expression analysis|GENETIC: microarray analysis|GENETIC: nucleic acid sequencing|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Comparison of RAD001 Versus Sunitinib in the First-line and Second-line Treatment of Patients With Metastatic Renal Cell Carcinoma
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: everolimus|DRUG: sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Closed Incision Negative Pressure Dressing (PREVENA) to Prevent Lower Extremity Amputation Wound Complications
Status: RECRUITING
Conditions: Amputation|Amputation; Postoperative, Sequelae|Wound Dehiscence|Seroma|Wound Infection, Surgical|Lymph Leakage
Interventions: DEVICE: PREVENA™ PEEL & PLACE™ Dressing Kit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Book Reading on Comfort, Hope, Anxiety and Vital Signs of Intensive Care Unit Patients
Status: NOT_YET_RECRUITING
Conditions: Hope|Comfort|Anxiety|Vital Signs
Interventions: OTHER: Reading a book
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of tDCS for Unilateral Neglect in Stroke Patients
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: Transcranical direct current stimulator|BEHAVIORAL: Visual inattention training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intensive Treatment Versus Standard Weekly Prolonged Exposure for Adults With Post-Traumatic Stress Disorder
Status: RECRUITING
Conditions: Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: Intensive treatment with prolonged exposure|BEHAVIORAL: Weekly delivered prolonged exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Leiomyosarcoma|Malignant Peripheral Nerve Sheath Tumor|Myxofibrosarcoma|Pleomorphic Rhabdomyosarcoma|Resectable Dedifferentiated Liposarcoma|Resectable Soft Tissue Sarcoma|Resectable Undifferentiated Pleomorphic Sarcoma|Soft Tissue Fibrosarcoma|Spindle Cell Sarcoma|Stage I Retroperitoneal Sarcoma AJCC (American Joint Committee on Cancer) v8|Stage I Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8|Stage IA Retroperitoneal Sarcoma AJCC v8|Stage IA Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8|Stage IB Retroperitoneal Sarcoma AJCC v8|Stage IB Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8|Stage II Retroperitoneal Sarcoma AJCC v8|Stage II Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8|Stage III Retroperitoneal Sarcoma AJCC v8|Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8|Stage IIIA Retroperitoneal Sarcoma AJCC v8|Stage IIIA Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8|Stage IIIB Retroperitoneal Sarcoma AJCC v8|Stage IIIB Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8|Storiform-Pleomorphic Malignant Fibrous Histiocytoma|Synovial Sarcoma|Undifferentiated High Grade Pleomorphic Sarcoma of Bone|Undifferentiated Pleomorphic Sarcoma|Undifferentiated Pleomorphic Sarcoma With Osteoclast-Like Giant Cells|Undifferentiated Pleomorphic Sarcoma, Inflammatory Variant|Undifferentiated Spindle Cell Sarcoma
Interventions: PROCEDURE: Definitive Surgical Resection|BIOLOGICAL: Nanoplexed Poly I:C BO-112|BIOLOGICAL: Nivolumab|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuro-pharmacological Properties of Repurposed Posaconazole in Glioblastoma: A Phase 0 Clinical Trial
Status: RECRUITING
Conditions: Glioblastoma|Glioblastoma Multiforme|Glioblastoma Multiforme of Brain|Glioblastoma Multiforme, Adult
Interventions: DRUG: Posaconazole Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Morphine Microdose Method Sensory Changes
Status: WITHDRAWN
Conditions: Analgesic Drug Dependence|Sensory Disorders|Chronic Pain
Interventions: BEHAVIORAL: Quantitative Sensory Tests|BEHAVIORAL: surveys
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Modified TAP (Transverse Abdominis Plane) Block in Colorectal Surgery
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: OTHER: Pain Scale|DRUG: Exparel Injectable Product|DRUG: Bupivacaine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Open Label Trial of INCB07839 to Determine Effect and Safety of INCB007839 Plus Trastuzumab in HER2 Positive Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: INCB007839|DRUG: INCB007839|DRUG: INCB007839|DRUG: INCB007839|DRUG: trastuzumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Platelet-rich Plasma Prolotherapy of Temporomandibular Joint Subluxation
Status: UNKNOWN
Conditions: Temporomandibular Joint Disorders
Interventions: BIOLOGICAL: PRP prolotherapy|BIOLOGICAL: Saline prolotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT