pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluating the Safety of Tenofovir Vaginal Gel in HIV-Uninfected Pregnant Women
Status: WITHDRAWN
Conditions: HIV Infections
Interventions: DRUG: 1% tenofovir gel|DRUG: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Permanent Cerebral Oxymetry Monitoring for Early Diagnosis and Treatment of Delayed Vasospasm After Subarachnoid Hemorrhage
Status: UNKNOWN
Conditions: Subarachnoid Hemorrhage
Interventions: DEVICE: Cerebral oxymetry monitoring (NIRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase I Trial of IV Fenretinide (4-HPR) Plus IV Safingol for Patients With Relapsed Malignancies
Status: TERMINATED
Conditions: Solid Tumor
Interventions: DRUG: Fenretinide (4-HPR) plus Intravenous Safingol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi Center Study Comparing the Efficacy of CAD EYE and the Standard of Care (White Light )
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DIAGNOSTIC_TEST: CAD EYE (Computer Aided Diagnosis ----?
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Florbetaben as an Amyloid Plaque Marker in Elderly Patients With Focal or Disseminated Superficial Hemosiderosis
Status: WITHDRAWN
Conditions: Amyloid Cerebral Angiopathy|Alzheimer Disease
Interventions: DEVICE: Pet scan with FBB|DEVICE: MRI scan|BIOLOGICAL: APO E genotyping
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Magnesium Sulphate for Attenuation of Hemodynamic Pressor Response After Myfield's Clamp Application
Status: COMPLETED
Conditions: Supratentorial Brain Tumor
Interventions: DRUG: MgSo4|DRUG: 0.9% NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Instrument Assisted Soft Tissue Mobilization vs Therapeutic Cupping on Hamstring Tightness Among Football Players
Status: RECRUITING
Conditions: Flexibility|Hamstring Tightness|Instrument Assisted Soft Tissue Mobilization|Range of Motion
Interventions: OTHER: Instrument Assisted Soft Tissue Mobilization|OTHER: Therapeutic Cupping Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma
Status: RECRUITING
Conditions: Stage III Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Echocardiography|BIOLOGICAL: Ipilimumab|PROCEDURE: Magnetic Resonance Elastography|PROCEDURE: Multigated Acquisition Scan|BIOLOGICAL: Nivolumab|BIOLOGICAL: Sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare the Patient Satisfaction and Effectiveness After Novel Application-based or Conventional Health Education of Bowel Preparation for Colonoscopy
Status: RECRUITING
Conditions: Colo-rectal Cancer|Colon Lesion
Interventions: OTHER: novel type of health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Palatability and Tolerability of Deferasirox Taken With Meals, With Different Liquids or Crushed and Added to Food
Status: COMPLETED
Conditions: Transfusional Hemosiderosis
Interventions: DRUG: deferasirox:
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study to Evaluate Basic Pharmacodynamic, Pharmacological and Toxicological Effects of the Newly Developed Crimean-Congo Hemorrhagic Fever Vaccine for Humans
Status: COMPLETED
Conditions: Crimean-Congo Hemorrhagic Fever
Interventions: BIOLOGICAL: KIRIM-KONGO-VAX|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: STUDY COMPARING TWO STANDARD TREATMENTS IN AUTOLOGOUS STEM CELL TRANSPLANTATION INELIGIBLE POPULATION AFFECTED BY MULTIPLE MYELOMA
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Velcade|DRUG: Melphalan|DRUG: Prednisone|DRUG: Lenalidomide|DRUG: Dexamethasone|DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMRT and Timing in Combination With EGFRTKI for Stage IV Non-small-cell Lung Cancer
Status: UNKNOWN
Conditions: Non-Small Cell Lung Cancer|Nonsmall Cell Lung Cancer|Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: EGFR-TK Inhibitor|RADIATION: Intensity Modulated Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fast-track Surgery for Perforated Peptic Ulcers
Status: COMPLETED
Conditions: Peptic Ulcer Perforation
Interventions: PROCEDURE: Surgical repair of perforated peptic ulcer|PROCEDURE: Surgical repair of perforated peptic ulcer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine, Cisplatin, and Nab-Paclitaxel Before Surgery in Patients With High-Risk Liver Bile Duct Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Resectable Cholangiocarcinoma|Stage IB Intrahepatic Cholangiocarcinoma AJCC v8|Stage II Intrahepatic Cholangiocarcinoma AJCC v8|Stage III Intrahepatic Cholangiocarcinoma AJCC v8|Stage IIIA Intrahepatic Cholangiocarcinoma AJCC v8|Stage IIIB Intrahepatic Cholangiocarcinoma AJCC v8
Interventions: DRUG: Cisplatin|DRUG: Gemcitabine|DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Absorbable Versus Permanent Mesh Fixation Trial in Laparoscopic Midline Ventral Hernia Repair
Status: COMPLETED
Conditions: Ventral Hernia
Interventions: DEVICE: permanent mesh fixation|DEVICE: absorbable mesh fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Enduring Exercise Habits: Trending Norms
Status: COMPLETED
Conditions: Healthy
Interventions: BEHAVIORAL: Majority Norm|BEHAVIORAL: Trending Minority Norm|BEHAVIORAL: Minority Norm|BEHAVIORAL: Control|BEHAVIORAL: Trending Majority Norm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Dabigatran Etexilate in Patients With Moderate Hepatic Impairment Compared to Subjects With Normal Hepatic Function
Status: COMPLETED
Conditions: Hepatic Insufficiency
Interventions: DRUG: Dabigatran etexilate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Antiplatelet for Minor Stroke Following Thrombolysis (EAST)
Status: RECRUITING
Conditions: Ischemic Stroke
Interventions: DRUG: Aspirin 100mg; Clopidogrel 300mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumors
Status: COMPLETED
Conditions: Medulloblastoma|Pontine Glioma|Ependymoma|Astrocytoma|PNET
Interventions: DRUG: Temozolomide|DRUG: ABT-888
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrohydraulic Versus Laser Lithotripsy for Treatment of Difficult to Remove Biliary Stones
Status: COMPLETED
Conditions: Gall Stones
Interventions: PROCEDURE: Laser Lithotripsy|PROCEDURE: Electrohydraulic Lithotripsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Australasian Nanoparticle-mediated Magnetically Enhanced Diffusion for Ischemic Stroke
Status: NOT_YET_RECRUITING
Conditions: Ischemic Stroke|Stroke
Interventions: DEVICE: Magnetically enhanced diffusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venetoclax-Dexamethasone in Relapsed and/or Refractory t(11;14) Amyloidosis
Status: RECRUITING
Conditions: AL Amyloidosis
Interventions: DRUG: Venetoclax Oral Tablet, 200 mg|DEVICE: FISH assay|DRUG: Venetoclax Oral Tablet, 400 mg|DRUG: Dexamethasone Oral, 10 mg|DRUG: Dexamethasone Oral, 20 mg|DRUG: Daratumumab Injection|DRUG: Bendamustine|DRUG: Pomalidomide|DRUG: Ixazomib|DRUG: Venetoclax MTD with Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Whey and Collagen Protein Blend on Protein Synthesis Rates
Status: COMPLETED
Conditions: Muscle Protein Synthesis
Interventions: DIETARY_SUPPLEMENT: Whey/collagen protein blend|BEHAVIORAL: Resistance exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Two-stage Hybrid Ablation or Thoracoscopic Epicardial Ablation for Long-standing Persistent Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Hybrid ablation|PROCEDURE: Thoracoscopic surgical ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drospirenone (3 mg) + Ethinyl Estradiol (0.02 mg) Tablets Relative to Yaz®
Status: RECRUITING
Conditions: Healthy Subjects
Interventions: DRUG: Drospirenone+ Ethinyl Estradiol Tablets-Test product|DRUG: Drospirenone+ Ethinyl Estradiol Tablets-Reference product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Early Stepping Verticalization in ICU for ABI Patients
Status: COMPLETED
Conditions: Brain Injury|Consciousness Disorders
Interventions: DEVICE: stepping verticalization|OTHER: conventional mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dose-escalation Safety and Immunogenicity Study to Compare MTBVAC to BCG in Newborns With a Safety Arm in Adults
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: MTBVAC|BIOLOGICAL: BCG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot Study
Status: COMPLETED
Conditions: Brain Tumor|Malignant Neoplasm of Fourth Ventricle of Brain
Interventions: PROCEDURE: Ommaya Reservoir|DRUG: Methotrexate|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Estimates of the Short-term Efficacy of Talineuren (TLN) and Placebo in Patients With Parkinson Disease
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: Talineuren|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect and Safety of TCM-FMD in Phlegm-Dampness Type Overweight/Obesity Patients(EASTAR)
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: TCM-FMD|OTHER: FMD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Extension of BPS-MR-PAH-201 in Pulmonary Arterial Hypertension (PAH) Patients
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Beraprost Sodium Modified Release
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sclerotherapy With Polidocanol Foam In The Treatment Of Hemorrhoidal Disease In Patients With Bleeding Disorders
Status: UNKNOWN
Conditions: Hemorrhoids|Bleeding Disorder
Interventions: PROCEDURE: Polidocanol foam sclerotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritional Supplement and Bone Health in Post-Menopausal Women
Status: UNKNOWN
Conditions: Bone and Bones|Osteoporosis Risk|Osteoporosis, Postmenopausal
Interventions: DIETARY_SUPPLEMENT: PLACEBO|DIETARY_SUPPLEMENT: MBPM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: ENDOTHELION Study Group: Effect of Bosentan in NAION Patients
Status: RECRUITING
Conditions: Ischemic Optic Neuropathy
Interventions: DRUG: bosentan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: EMG-controlled Virtual Reality to Improve Upper Extremity Function in Chronic Stroke Patients
Status: UNKNOWN
Conditions: Stroke|Upper Extremity Dysfunction
Interventions: DEVICE: Electromyography-controlled virtual and augmented reality using serious gaming
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Phase I Study of MRX34, MicroRNA miR-RX34 Liposomal Injection
Status: TERMINATED
Conditions: Primary Liver Cancer|SCLC|Lymphoma|Melanoma|Multiple Myeloma|Renal Cell Carcinoma|NSCLC
Interventions: DRUG: MRX34
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myocardial Microvascular Disease in ESRD
Status: TERMINATED
Conditions: End Stage Renal Disease|Myocardial Microvascular Disease
Interventions: PROCEDURE: Invasive FFR + CFR measurements are performed during coronary angiography using a pressure guide wire
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Erector Spinae Plane Block in Pediatric Hip Surgery
Status: UNKNOWN
Conditions: Analgesia
Interventions: PROCEDURE: Erector spinae plane block|PROCEDURE: caudal block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trastuzumab or Lapatinib Ditosylate in Treating Women With Early Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: BIOLOGICAL: trastuzumab|DRUG: lapatinib ditosylate|OTHER: laboratory biomarker analysis|PROCEDURE: adjuvant therapy|PROCEDURE: neoadjuvant therapy|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crossing the Divide: Piloting Integrated Care to Reduce Amputations Among Rural Patients With Diabetic Foot Ulcers
Status: ENROLLING_BY_INVITATION
Conditions: Diabetic Foot|Diabetic Ulcer of Left Foot|Diabetic Ulcer of Right Foot|Amputation
Interventions: OTHER: integrated care model
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: RCT to Evaluate the Renal Protective Effects of Remote Ischaemic Preconditioning in Peripheral Angioplasty
Status: UNKNOWN
Conditions: Peripheral Vascular Disease
Interventions: PROCEDURE: RIPC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study on the Efficacy of the Karl Storz Curved Fetoscope (11508aak) and Its Straight Version (11506akk) for In-utero Surgery
Status: RECRUITING
Conditions: In Utero Procedure Affecting Fetus or Newborn
Interventions: DEVICE: KARL STORZ fetoscope arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Centrifuge Values on Saliva High Sensitive C-Reactive Protein (Hs-CRP) Levels in Individuals With Different Smoking Amounts
Status: RECRUITING
Conditions: Smoking
Interventions: DIAGNOSTIC_TEST: saliva obtaining
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Deep Phenotyping of Peripheral Blood Cells and Circulating Factors in Metabolic Diseases
Status: RECRUITING
Conditions: NAFLD|Diabetes Mellitus|Obesity
Interventions: DIAGNOSTIC_TEST: Oral glucose tolerance test|DIAGNOSTIC_TEST: Liver Ultrasound|DIAGNOSTIC_TEST: Fibroscan of the Liver|DIAGNOSTIC_TEST: Magentic Resonance Imaging (MRI) of the liver
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Weight Management Among Breast Cancer Survivors
Status: COMPLETED
Conditions: Body Weight
Interventions: BEHAVIORAL: Device: FitBit Flex wrist band|BEHAVIORAL: Device: FitBit Aria weight scale|BEHAVIORAL: Diet Intake Messages|BEHAVIORAL: Behavioral Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With Obesity
Status: RECRUITING
Conditions: Obesity|Insulin Resistance|Inflammation
Interventions: DRUG: Colchicine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preemptive Analgesia for Primary Dysmenorrhoea
Status: COMPLETED
Conditions: Primary Dysmenorrhea
Interventions: DRUG: preemptive mefenamic acid|DRUG: mefenamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I Clinical Study of HRS-7058 in Patients With Advanced Malignant Tumour
Status: NOT_YET_RECRUITING
Conditions: Advanced Malignant Tumour
Interventions: DRUG: HRS-7058 capsule/ HRS-7058 tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Comparison of the Open Surgical and Endovascular Methods for the Treatment of Long Atherosclerotic Lesions of the Femoral-popliteal Segment Above the Knee, TASC II, Type D.
Status: UNKNOWN
Conditions: Atherosclerosis|Ischemia Limb|Superficial Femoral Artery Occlusion|Popliteal Artery Occlusion
Interventions: PROCEDURE: Endovascular recanalization with angioplasty and stenting with the biomimetic interwoven nitinol stent|PROCEDURE: Femoropopliteal proximal bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vessel Deformations and Restenosis After Stenting of the Popliteal Artery
Status: WITHDRAWN
Conditions: Peripheral Arterial Disease|Popliteal Artery Stenosis
Interventions: DEVICE: Interwoven stent|DEVICE: Laser-cut stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Safety and Tolerability of Varenicline (Chantix®) in Treating Spinocerebellar Ataxia Type 3
Status: COMPLETED
Conditions: Spinocerebellar Ataxia Type 3
Interventions: DRUG: varenicline|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pazopanib Hydrochloride in Treating Patients With Recurrent or Persistent Uterine Cancer
Status: COMPLETED
Conditions: Recurrent Uterine Corpus Sarcoma|Uterine Carcinosarcoma
Interventions: DRUG: Pazopanib Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Care Coordination and Proactive Care to Improve Utilization of Resources and Reduce Expenditure in High Risk Inflammatory Bowel Disease (IBD) Patients
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases
Interventions: BEHAVIORAL: Proactive Symptom Monitoring and Care Coordination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Pomaglumetad and Methamphetamine
Status: TERMINATED
Conditions: Methamphetamine Use Disorder
Interventions: DRUG: Pomaglumetad methionil|DRUG: Placebo|DRUG: Methamphetamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunosuppression in Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis (ALS)
Interventions: DRUG: Basiliximab|DRUG: Methylprednisolone|DRUG: Prednisone|DRUG: Tacrolimus|DRUG: Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Music and Brain Stimulation for Upper Extremity Performance in Patients With Corticobasal Syndrome
Status: RECRUITING
Conditions: Corticobasal Syndrome|Upper Extremity Dysfunction
Interventions: BEHAVIORAL: Patterned Sensory Enhancement (PSE)|DEVICE: Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Injection of SeeQ CdSe 655 Alt Nanoparticles for Patients With Degenerative Retinal Diseases
Status: COMPLETED
Conditions: Retinitis Pigmentosa
Interventions: DEVICE: SeeQ CdSe 655 ALT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Quantification of Rising the Osmotic Pressure in Diabetic Intraretinal Fluid Accumulation (Diabetic Macular Oedema)
Status: COMPLETED
Conditions: Diabetic Macular Oedema
Interventions: DRUG: Glycerol
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Family Mid-Upper Arm Circumference (MUAC) Follow-up After Recovery From Acute Malnutrition (MODAM-fMUAC)
Status: RECRUITING
Conditions: Severe Acute Malnutrition|Moderate Acute Malnutrition
Interventions: OTHER: nutrition, IYCF, WASH education|OTHER: scheduled anthropometric screening|OTHER: family MUAC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Nesiritide Use Following Cardiac Surgery in Infants
Status: TERMINATED
Conditions: Heart Defects, Congenital|Cardiopulmonary Bypass
Interventions: DRUG: nesiritide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Cervical Occlusion During Intrauterine Insemination (IUI)
Status: TERMINATED
Conditions: Infertility
Interventions: PROCEDURE: Intrauterine Insemination|PROCEDURE: IUI with the standard inseminator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Load Modification Versus Standard Exercise for Greater Trochanteric Pain Syndrome
Status: COMPLETED
Conditions: Hip Injuries|Pain|Therapy/Rehabilitation
Interventions: OTHER: Load modification education|OTHER: Standard exercise education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Of Flucloxacillin Capsules (250 mg and 500 mg)
Status: COMPLETED
Conditions: Infections, Bacterial
Interventions: DRUG: flucloxacillin 250 mg|DRUG: flucloxacillin 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early DHA/ARA Supplementation in Growth-restricted Very Preterm Infants: A Randomized Clinical Trial
Status: RECRUITING
Conditions: Infant Malnutrition|Light-For-Dates With Signs of Fetal Malnutrition|Premature|Nutrition Disorder, Infant
Interventions: DIETARY_SUPPLEMENT: DHA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TTFields and Pulsed Bevacizumab for Recurrent Glioblastoma
Status: TERMINATED
Conditions: Glioblastoma Multiforme|Glioblastoma|Malignant Glioma|GBM
Interventions: DRUG: Bevacizumab|DEVICE: Optune|OTHER: Brain MRI|OTHER: Quality of Life Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Clinical Study of Nintedanib to Inhibit Endometrial Fibrosis to Prevent Recurrence of Uterine Adhesions
Status: NOT_YET_RECRUITING
Conditions: Uterine Adhesions
Interventions: DRUG: Nintedanib 100 MG [Ofev]|DRUG: Nintedanib 150 MG [Ofev]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Robot Assisted Thoracic Surgery With Video Assisted Thoracic Surgery in Case of Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer|Postoperative Pain|Blood Loss|Inflammatory Response
Interventions: PROCEDURE: Robot assited thoracic surgery|PROCEDURE: Video assited thoracic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Investigation of Vitamin D3 Enriched, Reduced-fat Yellow Cheese Efficacy to Prevent Vitamin D Deficiency
Status: COMPLETED
Conditions: Hypovitaminosis D|Deficiency of Micronutrients
Interventions: OTHER: vitamin D3 enriched, reduced-fat yellow cheese|OTHER: plain (non-fortified) reduced-fat yellow cheese
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Toulouse Male Long Term Bed Rest 2001-2002
Status: COMPLETED
Conditions: Simulation of Weightlessness by Anti-Orthostatic Long Term Bed Rest
Interventions: DRUG: Ethidronate|BEHAVIORAL: Physical training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Volrustomig in Women With High Risk Locally Advanced Cervical Cancer (eVOLVE-Cervical)
Status: RECRUITING
Conditions: Locally Advanced Cervical Cancer
Interventions: BIOLOGICAL: Volrustomig|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Use of Hepatitis C Positive Donors for Hepatitis C Negative Lung Transplant Recipients With Post-transplant Treatment With Mavyret
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Mavyret
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment and Prevention of Traditional Chinese Medicines (TCMs) on COVID-19 Infection
Status: UNKNOWN
Conditions: Pneumonia Caused by Human Coronavirus (Disorder)
Interventions: DRUG: Conventional medicines (Oxygen therapy, alfa interferon via aerosol inhalation, and lopinavir/ritonavir) and Traditional Chinese Medicines (TCMs) granules|DRUG: Conventional medicines (Oxygen therapy, alfa interferon via aerosol inhalation, and lopinavir/ritonavir)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Different Assisted Mechanical Ventilation in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients: Pressure Support Ventilation (PSV), Neurally Adjusted Ventilatory Assist (NAVA) and Controlled by Patient
Status: COMPLETED
Conditions: ALI/ARDS Patients
Interventions: PROCEDURE: PSV|PROCEDURE: NAVA|PROCEDURE: patient-controlled
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Racial and Genetic Biomarkers of Response in Tissue Samples From Patients With Endometrial Cancer
Status: COMPLETED
Conditions: Stage I Uterine Corpus Cancer|Stage II Uterine Corpus Cancer|Stage III Uterine Corpus Cancer|Stage IV Uterine Corpus Cancer
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Study of Socioeconomic and Demographic Variables
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nivolumab, Ifosfamide, Carboplatin, and Etoposide as Second-Line Therapy in Treating Patients With Refractory or Relapsed HL
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Hodgkin Lymphoma|Refractory Hodgkin Lymphoma
Interventions: DRUG: Carboplatin|DRUG: Etoposide|DRUG: Ifosfamide|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Two Formulations of Buprenorphine HCl in Opioid-dependent Subjects on Buprenorphine Maintenance Therapy (Study P04451) (COMPLETED)
Status: COMPLETED
Conditions: Opioid Dependency
Interventions: DRUG: Buprenorphine hydrochloride marketed sublingual tablet (Subutex)|DRUG: Buprenorphine hydrochloride fast dissolving tablet (FDT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Elective Caesarean Sections for Predicting Post-spinal Hypotension Role of Overactive Bladder?
Status: COMPLETED
Conditions: 18-45 Range of Age|Cesarean Section|Primigravid
Interventions: OTHER: bupivacaine,fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Evaluation of Perioperative Management of Curative Anticoagulants in the Geriatric Perioperative Unit in Patient Hospitalized for Femoral Neck Fracture.
Status: COMPLETED
Conditions: Anticoagulants; Circulating, Hemorrhagic Disorder|Femoral Neck Fractures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Blinatumomab Consolidation Post Autologous Stem Cell Transplantation in Patients With Diffuse Large B-Cell Lymphoma (DLBCL)
Status: COMPLETED
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: Blinatumomab|PROCEDURE: Autologous stem cell transplant|DRUG: Carmustine|DRUG: Etoposide|DRUG: Cytarabine|DRUG: Melphalan|PROCEDURE: Peripheral blood draws
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benchmarking Trial Between France and Australia Comparing Management of Primary Rectal Cancer Beyond TME (Total Mesorectum Excision) and Locally Recurrent Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: OTHER: Blinded inter-country reading of pelvic MRI (Magnetic Resonance Imaging)|OTHER: MDT (Multidisciplinary team) meeting observation|OTHER: Semi-structured exploratory interviews and focus group with MDT health professional attendees
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Warmed Socks Developed as Wearable Technology on Hypothermia, Thermal Comfort Perception and Shivering
Status: NOT_YET_RECRUITING
Conditions: Wearable Technology|Hypothermia|Shivering|Thermal Comfort Perception
Interventions: OTHER: Heated socks to be developed with wearable technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)
Status: RECRUITING
Conditions: Nicotine Dependence|Tobacco Toxicity|Cardiovascular Risk Factors
Interventions: OTHER: Standardized Research E-Cigarette (SREC)|OTHER: Over the Counter E-Cigarette (EC)|BEHAVIORAL: Biological Samples|OTHER: Smoking-related Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Impact of a Pharmacist Intervention on Post-discharge Hypnotic Drug Discontinuation in Geriatric Inpatients
Status: COMPLETED
Conditions: Hypnotic Withdrawal
Interventions: OTHER: multifaceted pharmacist-led intervention|OTHER: Usual care group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pelvic Neuro-Angiogenesis in Deep Endometriosis
Status: RECRUITING
Conditions: Endometriosis-related Pain|Endometriosis|Deep Endometriosis|Endometriosis; Peritoneum
Interventions: PROCEDURE: Laparoscopic Endometriosis Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Either Osimertinib in Participants With Unresectable, Locally Advanced, or Metastatic Non-Small Cell Lung Cancer, or With Cetuximab in Participants With Metastatic Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer|Non-Small Cell Lung Cancer
Interventions: DRUG: GDC-1971|DRUG: Osimertinib|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Missing Link- Development and Feasibility Evaluation of Person-centred Transitions From the Stroke Unit to the Home
Status: COMPLETED
Conditions: Stroke
Interventions: BEHAVIORAL: Co-designed person-centred care transitions|BEHAVIORAL: Current care transitions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Safety and Efficacy of Ribociclib and Trametinib in Patients With Metastatic or Advanced Solid Tumors
Status: TERMINATED
Conditions: Solid Tumors for Phase Ib|Pancreatic Cancer for Phase II|Colorectal Cancer for Phase II
Interventions: DRUG: ribociclib|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing 11C-Choline (11C-CH) PET to Distinguish True Tumor Progression From Pseudoprogression in High-grade Gliomas
Status: COMPLETED
Conditions: Brain Cancer
Interventions: DEVICE: PET scan|RADIATION: C-Choline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectıveness Of Cognıtıve Behavıoral-Based Psychoeducatıon In College Students Wıth Smartphone Addıctıon
Status: COMPLETED
Conditions: Addictive Behavior
Interventions: OTHER: psycho-education program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: NAD-brain: a Pharmacokinetic Study of NAD Replenishment Therapy
Status: RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: nicotinamide riboside|DIETARY_SUPPLEMENT: nicotinamide mononucleotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia
Status: RECRUITING
Conditions: Recurrent Acute Leukemia of Ambiguous Lineage|Recurrent Acute Lymphoblastic Leukemia|Recurrent Acute Myeloid Leukemia Due to Lineage Switch From Acute Leukemia of Ambiguous Lineage|Recurrent Acute Myeloid Leukemia Due to Lineage Switch From B Acute Lymphoblastic Leukemia, KMT2A-Rearranged|Recurrent Acute Myeloid Leukemia Due to Lineage Switch From Mixed Phenotype Acute Leukemia|Recurrent Mixed Phenotype Acute Leukemia|Refractory Acute Leukemia of Ambiguous Lineage|Refractory Acute Lymphoblastic Leukemia|Refractory Acute Myeloid Leukemia Due to Lineage Switch From Acute Leukemia of Ambiguous Lineage|Refractory Acute Myeloid Leukemia Due to Lineage Switch From B Acute Lymphoblastic Leukemia, KMT2A-Rearranged|Refractory Acute Myeloid Leukemia Due to Lineage Switch From Mixed Phenotype Acute Leukemia|Refractory Mixed Phenotype Acute Leukemia
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|DRUG: Calaspargase Pegol|DRUG: Cytarabine|PROCEDURE: Echocardiography|DRUG: Fludarabine Phosphate|DRUG: Hydrocortisone Sodium Succinate|PROCEDURE: Lumbar Puncture|DRUG: Methotrexate|PROCEDURE: Multigated Acquisition Scan|DRUG: Prednisolone|DRUG: Prednisone|DRUG: Revumenib|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase IA Study of AAVrh.10hFXN Gene Therapy for the Cardiomyopathy of Friedreich's Ataxia
Status: RECRUITING
Conditions: Friedreich Ataxia|Cardiomyopathies|Cardiac Hypertrophy|Myocardial Fibrosis
Interventions: BIOLOGICAL: AAVrh.10hFXN, serotype rh.10 adeno-associated virus (AAV) gene transfer vector expressing the cDNA coding for human FXN|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin Glycinate on Metabolic Control and Inflammatory Mediators in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Metformin glycinate|DRUG: Metformin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Combining LY2157299 With Temozolomide-based Radiochemotherapy in Patients With Newly Diagnosed Malignant Glioma
Status: COMPLETED
Conditions: Glioma
Interventions: DRUG: LY2157299|DRUG: Radiation|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Quetiapine for Pediatric Delirium
Status: TERMINATED
Conditions: Delirium
Interventions: DRUG: quetiapine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Consumer-Based Activity Monitor in Evaluating and Measuring Activity of Older Patients With Abdominal Cancer Undergoing Surgery
Status: COMPLETED
Conditions: Malignant Gastrointestinal Neoplasm|Malignant Peritoneal Neoplasm
Interventions: DEVICE: Management of Therapy Complications Fitbit Zip (portable pedometer device)|OTHER: Questionnaire Administration|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cerebral Oxygenation After Lung Resection
Status: COMPLETED
Conditions: Elective|Lung Resection|Surgery
Interventions: PROCEDURE: Monitoring of cerebral oxygenation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Norepinephrine Infusion During Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Cardiac Surgery|Cardiopulmonary Bypass
Interventions: DRUG: Placebo|DRUG: Norepinephrine|OTHER: Increase infusion rate|OTHER: Decrease infusion rate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Adjunct Low Frequency Repetitive Transcranial Magnetic Stimulation With Physiotherapy Enhance Upper Extremity Function Restoration
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Low frequency rTMS|BEHAVIORAL: structured physiotherapy upper limb training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Abuse Potential and Human Pharmacology of Methylone
Status: UNKNOWN
Conditions: Substance Use|Healthy Subjects
Interventions: DRUG: Methylone|DRUG: 3,4-methylenedioxymethamphetamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Serum C Type Natriuretic Peptide Levels Between Polycystic Ovary Syndrome Patients and Healthy Women
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|c Type Natriuretic Peptide|Menstrual Irregularity|Hyperandrogenism
Interventions: DIAGNOSTIC_TEST: C type natriuretic peptide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pyrotinib, Trastuzumab And Abraxane in HER2-positive MBC With Brain Metastasis
Status: UNKNOWN
Conditions: Breast Cancer|HER2-positive Breast Cancer
Interventions: DRUG: Pyrotinib Plus And|DRUG: Trastuzumab|DRUG: Abraxane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Loss of Effect of Aspirin on Platelet Aggregation During Chronic Administration
Status: TERMINATED
Conditions: Platelet Aggregation
Interventions: DRUG: aspirin|DRUG: aspirin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase IIa Study to Investigate the Efficacy and Safety of SPP635 in Diabetic and Hypertensive Patients With Albuminuria
Status: COMPLETED
Conditions: Hypertension|Type II Diabetes Mellitus
Interventions: DRUG: SPP635
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The GRK2 Inhibitor Paroxetine as a Novel Adjunct to Conventional Therapy in Rheumatoid Arthritis Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Paroxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A First In Human (FIH) Study to Learn if Different Doses of ALN-ANG3 Are Safe and Well Tolerated in Healthy Adults
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: ALN-ANG3|DRUG: Placebo (PB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Combination of Amlodipine/Valsartan on 24H Blood Pressure Control With One Nocturnal or Diurnal Intake a Day
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Amlodipine|DRUG: Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coronary Artery Bypass and Nitrate Oral Supplementation
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DIETARY_SUPPLEMENT: Sodium nitrate|OTHER: Sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Autonomous Digital CBT Intervention for Opioid Use Disorder in Individuals With Co-Occurring Internalizing Disorders
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder|Anxiety|Depression
Interventions: BEHAVIORAL: NEAT-O program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ACDF Comparison Trial
Status: WITHDRAWN
Conditions: Cervical Spine Disc Disease|Surgery|Fusion of Spine|Degenerative Disc Disease
Interventions: OTHER: Allograft Fusion|DEVICE: Cohere PEEK Fusion Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of ALX-0171 in Japanese Children Hospitalized for Respiratory Syncytial Virus Lower Respiratory Tract Infection
Status: TERMINATED
Conditions: Respiratory Syncytial Virus Lower Respiratory Tract Infection
Interventions: BIOLOGICAL: ALX-0171 1.5 mg/kg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Ketorolac Trial
Status: RECRUITING
Conditions: Headache, Migraine
Interventions: DRUG: Ketorolac|DRUG: Prochlorperazine|DRUG: Diphenhydramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT