pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Evaluate Safety and Efficacy of IBI306, a PCSK9 Monoclonal Antibody in Chinese Subjects With Homozygous Familial Hypercholesterolemia
Status: COMPLETED
Conditions: Homozygous Familial Hypercholesterolemia
Interventions: BIOLOGICAL: IBI306|BIOLOGICAL: IBI306
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Statin Therapy Vs. Therapeutic Lifestyle Changes and Supplements
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DRUG: simvastatin|DRUG: red yeast rice|DRUG: pharmaceutical grade fish oil|BEHAVIORAL: therapeutic lifestyle changes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Web-Based Cognitive Behavior Therapy for Procrastination
Status: NOT_YET_RECRUITING
Conditions: Mental Health Issue
Interventions: OTHER: Internet Based Intervention - GUIDED|OTHER: Internet Based Intervention - WİTHOUT GUİDANCE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Deceased Donor Bladder or Combined Kidney-bladder Transplantation: a Phase 0 First-in-human Study
Status: RECRUITING
Conditions: Bladder Disease|Bladder, Neurogenic|Bladder Cancer|Kidney Failure
Interventions: PROCEDURE: Bladder Transplantation|PROCEDURE: Combined Kidney and Bladder Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-CoagulaTion on Left Ventricular Thrombus After ST Segment Elevation Myocardial Infarction
Status: RECRUITING
Conditions: ST-segment Elevation Myocardial Infarction (STEMI)|Left Ventricular Thrombus
Interventions: DRUG: Rivaroxaban 15 MG [Xarelto]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulp Protection in Selective Carious Tissue Removal
Status: COMPLETED
Conditions: Dental Caries
Interventions: DEVICE: Self-etching Adhesive|DEVICE: Glass Ionomer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Salivary Gland Transplantation in the Treatment of Dry Eye in Patients With Stevens-Johnson Syndrome.
Status: COMPLETED
Conditions: Symblepharon|Dry Eye|Ocular Surface Disease|Transplantation
Interventions: PROCEDURE: Salivary Gland and Labial Mucous Membrane Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Pharmacology Study of Atezolizumab (MPDL3280A) Administered With Obinutuzumab or Tazemetostat in Participants With Relapsed/Refractory Follicular Lymphoma and Diffuse Large B-cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Atezolizumab|DRUG: Obinutuzumab|DRUG: Tazemetostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Safety, Tolerability, and Efficacy of NCR100 Injection in the Treatment of Subjects With KOA
Status: NOT_YET_RECRUITING
Conditions: Knee Osteoarthritis
Interventions: BIOLOGICAL: NCR100 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketogenic Diet Adjunctive to HD-MTX Chemotherapy for Primary Central Nervous System Lymphoma
Status: UNKNOWN
Conditions: Primary Central Nervous System Lymphoma
Interventions: DIETARY_SUPPLEMENT: ketogenic diet|DIETARY_SUPPLEMENT: Routine diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-Dose Intravenous Immunoglobulin to Treat Cerebellar Degeneration
Status: COMPLETED
Conditions: Spinocerebellar Degenerations
Interventions: DRUG: high-dose intravenous immunoglobulin (IVIG)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Midodrine and Fludrocortisone for Vasovagal Syncope
Status: UNKNOWN
Conditions: Syncope, Vasovagal
Interventions: DRUG: Midodrine Hydrochloride Tablets|DRUG: Fludrocortisone Acetate Tablets|BEHAVIORAL: Lifestyle modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Lumateperone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of BETOPTIC S 0.25% and Timolol Gel-forming Solution 0.25% and 0.5% in Pediatric Patients With Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: BETOPTIC S (betaxolol HCl)|DRUG: Timolol Gel-forming Solution (TGFS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of 8-Week Dietary DHA Supplementation on Cerebral Blood Flow and Metabolic Function
Status: COMPLETED
Conditions: Healthy|Attention
Interventions: DIETARY_SUPPLEMENT: docosahexaenoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Chlorzoxazone on Moderate to Severe Postoperative Pain After Spine Surgery
Status: COMPLETED
Conditions: Chlorzoxazone|Postoperative Pain
Interventions: DRUG: Placebo|DRUG: Chlorzoxazone|DRUG: Morphine|DRUG: Zofran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intensive Care Unit (ICU) Sleep Quality and Neurocognitive Performance
Status: COMPLETED
Conditions: Neurobehavioral Manifestations|Sleep Deprivation|Dyssomnias
Interventions: BEHAVIORAL: Sleep promoting interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Trials to Compare the Effects of Pioglitazone and Evogliptin on Hepatic Fibrosis in Patients With Chronic Hepatitis B With Significant Hepatic Fibrosis With Type 2 Diabetes
Status: UNKNOWN
Conditions: Chronic Hepatitis B With Significant Hepatic Fibrosis With Type 2 Diabetes
Interventions: DRUG: gluconon tab 15mg|DRUG: suganon tab 5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Avelumab in Combination With AVB-S6-500 in Patients With Advanced Urothelial Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Urothelial Carcinoma
Interventions: DRUG: Avelumab|DRUG: AVB-S6-500
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feather Edge Versus Deep Chamfer Finish Line Marginal Design in Complete Coverage Bruxzir Zirconia Crowns
Status: UNKNOWN
Conditions: Premolars Need Full Coverage Restoration
Interventions: OTHER: deep chamfer|OTHER: feather edge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bimatoprost 0.03% Solution With NB-UVB Versus Their Use With Fractional Carbon Dioxide Laser in Treatment of Generalized Vitiligo
Status: UNKNOWN
Conditions: Generalized Vitiligo
Interventions: DRUG: Bimatoprost 0.03% ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biplanar PSI Slope-reducing MOWHTO With Tibial Tuberosity Serving as Hinge Axis: Cadaveric Study
Status: UNKNOWN
Conditions: Knee Disease|Knee Osteoarthritis|Knee Injuries and Disorders
Interventions: DEVICE: Biplanar PSI slope-reducing MOWHTO.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Gamified Occupational Therapy for Adolescents With Duchenne Muscular Dystrophy
Status: RECRUITING
Conditions: Duchenne Muscular Dystrophy|Gamification|Occupational Therapy
Interventions: OTHER: Gamified occupational therapy programme|OTHER: Classic occupational therapy programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Investigate Safety, Tolerability and Clinical Response With SAR441566 Compared With Placebo in Participants With Mild to Moderate Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: SAR441566|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: rTMS in Spasmodic Dysphonia
Status: COMPLETED
Conditions: Spasmodic Dysphonia|Laryngeal Dystonia
Interventions: DEVICE: 1Hz repetitive transcranial magnetic stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Vitamin D in the Severely Mentally Ill
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Message Framing and Policy Support for Front-of-package Labeling
Status: RECRUITING
Conditions: Diet, Healthy
Interventions: BEHAVIORAL: Exposure to information framing message|BEHAVIORAL: Exposure to healthier choices framing message|BEHAVIORAL: Exposure to industry framing message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Statins and prOgression of Coronary atheRosclerosis in melanomA Patients Treated With chEckpoint inhibitorS
Status: RECRUITING
Conditions: Melanoma|Atherosclerosis
Interventions: DRUG: Atorvastatin Calcium 40Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study to Evaluate Luspatercept in Subjects With Myeloproliferative Neoplasm-associated Myelofibrosis Who Have Anemia With and Without Red Blood Cell-transfusion Dependence
Status: COMPLETED
Conditions: Primary Myelofibrosis|Anemia
Interventions: DRUG: Luspatercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving HIV-1 Control in Africa With Long Acting Antiretrovirals
Status: RECRUITING
Conditions: HIV-1-infection
Interventions: DRUG: Cabotegravir/Rilpivirine|DRUG: Antiretroviral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antiplatelet Effect of Ginkgo Diterpene Lactone Meglumine Injection in Acute Ischemic Stroke
Status: RECRUITING
Conditions: Ischemic Stroke
Interventions: DRUG: Ginkgo Diterpene Lactone Meglumine Injection|DRUG: Acetylsalicylic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Intervention Study of Anhedonia and Pain Empathy in Depression
Status: UNKNOWN
Conditions: Treatment Resistant Depression|Problem Management Plus|Event-Related Potentials
Interventions: BEHAVIORAL: PM+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of AuroLase(tm) Therapy in Refractory and/or Recurrent Tumors of the Head and Neck
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DEVICE: AuroLase Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tumor TARGET Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: Volumetric Modulated Arc Therapy (VMAT) and High-Dose Rate (HDR) Radiotherapy|OTHER: No Active Treatment - completed Prior Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Family Nurture Intervention in the CHoNJ NICU
Status: TERMINATED
Conditions: Premature Birth
Interventions: OTHER: Full Term EEG|BEHAVIORAL: Facilitated Infant Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Split Dose Golytely With Amitiza Pretreatment Versus Split Dose Golytely Plus Placebo in Outpatient Colonoscopy
Status: COMPLETED
Conditions: Bowel Preparation for Colonoscopy
Interventions: DRUG: lubiprostone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Hyperthyroidism and Its Treatment in Graves' Disease to Early Marker of Atherosclerosis
Status: COMPLETED
Conditions: Hyperthyroidism|Graves Disease|Atherosclerosis of Artery|Pathophysiology
Interventions: DRUG: Propylthiouracil|DRUG: Methimazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interest of Broadband Spectroscopy Analysis by Infrared Laser on Liquid Biopsies in Breast Cancer Screening
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer Female|BRCA1 Mutation|BRCA2 Mutation
Interventions: OTHER: liquid biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Imaging Perfusion Restrictions From Extracellular Solid Stress - An Open-label Losartan Study
Status: ENROLLING_BY_INVITATION
Conditions: Glioblastoma|Brain Metastases
Interventions: DRUG: Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Light Therapy Device LUMINETTE® in Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder|Unipolar Depression
Interventions: DEVICE: active light therapy (LUMINETTE®)|DEVICE: placebo light therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Pharmacodynamics and Pharmacodynamics Equivalence of Antareit 800 mg/10 ml Oral Suspension and Riopan 800 mg Chewable Tablets in Healthy Volunteers
Status: RECRUITING
Conditions: Heartburn|Acid-dependent Diseases of the Gastrointestinal Tract|Symptomatic Treatment of Gastric and Duodenal Ulcers
Interventions: DRUG: Antareit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of a Smartphone-based Intervention for Suicidal Inpatients
Status: WITHDRAWN
Conditions: Suicide, Attempted|Suicidal Ideation|Hopeless
Interventions: BEHAVIORAL: Ecological Momentary Intervention|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Using Different Anesthetics on the Prognosis of Primary Lung Tumors and Its Mechanism of Action
Status: RECRUITING
Conditions: Lung Cancer|Progression, Disease|Anesthesia
Interventions: DRUG: Propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, Tolerability of Pegaptanib Sodium (Macugen) in Filipino Patients With Neovascular Age Related Macular Degeneration.
Status: WITHDRAWN
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: Macugen
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Stepcare Extended Follow-up Substudy
Status: RECRUITING
Conditions: Cardiac Arrest With Successful Resuscitation|Hypoxia, Brain|Cognitive Impairment|Caregiver Burden
Interventions: DEVICE: Feed back controlled temperature device|OTHER: High MAP|OTHER: Deep sedation|OTHER: Fever control without a device|OTHER: Low MAP|OTHER: Minimal sedation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Arthroscopic Evaluation of Cartilage Regeneration After Opening-wedge High Tibial Osteotomy
Status: COMPLETED
Conditions: Osteo Arthritis Knee
Interventions: PROCEDURE: initial arthroscopy with medial opening-wedge high tibial osteotomy fixed by a plate system then second look arthroscopy with plate removal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CPT-L to Improve Outcomes for Individuals With HIV and PTSD
Status: RECRUITING
Conditions: PTSD|Hiv
Interventions: BEHAVIORAL: Cognitive Processing Therapy- Lifesteps (CPT-L)|BEHAVIORAL: Lifesteps
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Metastatic Breast Cancer
Status: TERMINATED
Conditions: Male Breast Cancer|Recurrent Breast Cancer|Stage IV Breast Cancer
Interventions: BIOLOGICAL: recombinant vaccinia-MUC1 vaccine|BIOLOGICAL: recombinant vaccinia-TRICOM vaccine|OTHER: laboratory biomarker analysis|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Intramyometrial Oxytocin Improve Outcome in Elective Cesarean Delivery?
Status: WITHDRAWN
Conditions: Postpartum Hemorrhage|Uterine Atony
Interventions: DRUG: Oxytocin|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Combination of Osimertinib, Platinum and Etoposide for Patients With Metastatic EGFR Mutant Lung Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer
Interventions: DRUG: Osimertinib|DRUG: Platinum|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open, Randomised, Multi-center Study of on Demand Versus Continuous Esomeprazole Treatment in Patient With GERD
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of KAF156 in Combination With LUM-SDF in Adults and Children With Uncomplicated Plasmodium Falciparum Malaria
Status: COMPLETED
Conditions: Acute Uncomplicated Plasmodium Falciparum Malaria
Interventions: DRUG: KAF156|DRUG: Coartem|DRUG: Lumefantrine Solid Dispersion Formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Lipitor (Atorvastatin) for the Treatment of Polycystic Ovary Syndrome (PCOS) in Women With Elevated Low-density Lipoprotein (LDL) Cholesterol
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Lipitor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Kinetic Properties of an Autologous Microbiome Transplant in Adult Atopic Dermatitis Patients
Status: WITHDRAWN
Conditions: Atopic Dermatitis|Eczema
Interventions: BIOLOGICAL: Moisturizer with each subject's own antimicrobial bacteria
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Inhaled Triple Therapies Over the Small Airway in Biomass Exposure
Status: RECRUITING
Conditions: COPD Bronchitis|Pollution Related Respiratory Disorder
Interventions: DRUG: Vilanterol / Umeclidinium (25/62.5 mcg)|DRUG: Fluthicasone / Vilanterol / Umeclidinium (100/25/62.5 mcg)|DRUG: Beclomethasone / Formoterol / Glycopyrronyum 100/6/12.5 mcg|DRUG: Budesonide / Formoterol / Glycopyrronyum 160/4.8/7.2 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Transcatheter Mitral Valve Repair After Myocardial Infarction
Status: NOT_YET_RECRUITING
Conditions: Acute Mitral Regurgitation
Interventions: PROCEDURE: Early transcatheter edge-to-edge mitral valve repair (TEER).|DEVICE: MitraClip|OTHER: Optimal medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Delayed Release Diclofenac Sodium Formulation vs Voltaren®
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Radiolabelled Diclofenac Tablet A|DRUG: Radiolabelled Diclofenac tablet B|DRUG: Radiolabelled Diclofenac tablet C|DRUG: Diclofenac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Clinical Trial of a New Rectum Cooling System on Patients of Hypoxic-ischemic Brain Damage
Status: COMPLETED
Conditions: Hypoxic-Ischemic Encephalopathy
Interventions: DEVICE: Rectum cooling system|DEVICE: Hyper-hypothermia blanket
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Navigation-assisted OrthoPilot® Elite and Robotic-assisted MAKO® Total Knee Arthroplasty
Status: RECRUITING
Conditions: Osteoarthritis, Knee|Joint Diseases|Rheumatoid Arthritis of Knee|Posttraumatic Arthropathy
Interventions: DEVICE: Navigated total knee arthroplasty|DEVICE: Robot assisted total knee arthroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Endostar First-line Treatment of Advanced Non-small Cell Lung Squamous Carcinoma
Status: UNKNOWN
Conditions: Advanced Lung Squamous Carcinoma
Interventions: BIOLOGICAL: Endostar|DRUG: Docetaxel|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Walkbot Robotic Training for Improvement in Gait
Status: COMPLETED
Conditions: Ischemic Stroke|Gait, Hemiplegic
Interventions: DEVICE: Walkbot|BEHAVIORAL: Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine Dose, Safety, and Efficacy of Durvalumab as Monotherapy and in Combination Therapy in Subjects With Lymphoma or Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Lymphoma|Leukemia, Lymphocytic, Chronic, B-Cell
Interventions: DRUG: Durvalumab|DRUG: Lenalidomide|DRUG: Rituximab|DRUG: Ibrutinib|DRUG: Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caregivers Tracheal Aspiration Training
Status: COMPLETED
Conditions: Tracheostomy|Family Caregivers|Aspiration
Interventions: OTHER: simulation model training|OTHER: mobile app training|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Intravitreal Bone Marrow Stem Cells on Ischemic Retinopathy
Status: UNKNOWN
Conditions: Ischemia
Interventions: BIOLOGICAL: Intravitreal Bone Marrow Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Neoadjuvant Treatment of Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma.
Status: RECRUITING
Conditions: Efficacy and Safty of Camrelizumab Plus S-1 Maintenance After First-line Induction Chemotherapy for GC
Interventions: DRUG: Camrelizumab+S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decitabine Versus Conventional Chemotherapy for Maintenance Therapy of Acute Myeloid Leukemia With t(8;21)
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Decitabine|DRUG: Daunorubicin, Cytarabine|DRUG: Mitoxantrone, Cytarabine|DRUG: Aclacinomycin, Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety Study of the Bispecific T-cell Engager Blinatumomab (MT103) in Patients With Relapsed NHL
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma, Relapsed
Interventions: BIOLOGICAL: Blinatumomab (MT103)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Bee Venom to Treat Knee Osteoarthritis
Status: UNKNOWN
Conditions: Persons With Mild to Moderate Knee Osteoarthritis
Interventions: PROCEDURE: Injecting bee venom as a treatment for OA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Akkermansia Muciniphila WST01 Strain in Overweight or Obese Patients With Type 2 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Obese|Overweight|Type 2 Diabetes
Interventions: DRUG: WST01 strain product|DRUG: placebo powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease
Status: NOT_YET_RECRUITING
Conditions: Crohn's Disease
Interventions: DRUG: Risankizumab|DRUG: Lutikizumab|DRUG: ABBV-382|DRUG: Risankizumab|DRUG: ABBV-382
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HR070803 in Combination With Oxaliplatin, 5-fluorouracil/LV Versus GX as Adjuvant Therapy for Pancreatic Cancer
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: HR070803; Oxaliplatin; 5Fluorouracil; Calcium folinate|DRUG: gemcitabine; capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monoclonal Antibody F19 in Treating Patients With Advanced or Metastatic Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: monoclonal antibody F19|RADIATION: iodine I 131 monoclonal antibody F19
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Follow-up Study on the Sustained Impact of Alive & Thrive Interventions on Infant and Young Child Feeding Practices
Status: COMPLETED
Conditions: Breastfeeding|Complementary Feeding
Interventions: BEHAVIORAL: Interpersonal behavioral change communication|BEHAVIORAL: Mass media
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Treatment of COVID-19 Positive/Negative Bangladeshi Adults With Severe Respiratory Complaints by a Locally Made bCPAP: Feasibility Study
Status: COMPLETED
Conditions: Severe Pneumonia|Acute Respiratory Distress Syndrome|Covid19
Interventions: DEVICE: Adult bubble CPAP oxygen therapy device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: The Physiological Chronobiome Modified by Age, Sex and Under Evoked Conditions
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy|Healthy Aging
Interventions: OTHER: Fatty meal to challenge the physiological chronobiome in healthy young and old
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: HealthMindr App to Increase Pre-exposure Prophylaxis (PrEP) Uptake and Retention Among Men Who Have Sex With Men (MSM)
Status: COMPLETED
Conditions: HIV Infections
Interventions: BEHAVIORAL: HealthMindr App|BEHAVIORAL: Control App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prehabilitation and RecOVERy From Surgery for Breast Cancer Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Exercise|Breast Neoplasm Female
Interventions: BEHAVIORAL: Exercise-based multi-phasic, multi-modal intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Double Tract Anastomosis and Esophagogastrostomy After Radical Proximal Gastrectomy
Status: UNKNOWN
Conditions: Gastric Cancer|GastroEsophageal Cancer
Interventions: PROCEDURE: Double tract anatomosis|PROCEDURE: Esophagogastrostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short-term Effectiveness of Gabapentin Versus Placebo in Acute Lumbosacral Radiculalgia by Herniation Disc (GRADE)
Status: RECRUITING
Conditions: Radiculopathy of Lumbosacral Spine Due to Disc Disorder
Interventions: DRUG: Gabapentin 300mg|DRUG: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chemo-immunotherapy Induction Followed by Hypo-radiotherapy in LA-NSCLC(CHIC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer, Non-small Cell
Interventions: RADIATION: hypofractionated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate Nesiritide in Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery A014 / NAPA
Status: COMPLETED
Conditions: Coronary Artery Bypass Surgery|Coronary Heart Disease|Coronary Artery Bypass Grafting|Cardiopulmonary Bypass|Ischemic Heart Disease|Congestive Heart Failure
Interventions: DRUG: Nesiritide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Injectable Contraceptive and Oral Contraceptive Administered After Surgical Treatment of Endometriosis With Pain
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: intramuscular depot medroxyprogesterone acetate|DRUG: ethinyl estradiol 30 micrograms, gestodene 75 micrograms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Placebo-controlled Study of ISA247 in Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: voclosporin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Alveolar Proteinosis GM-CSF Inhalation Efficacy Trial in Japan
Status: COMPLETED
Conditions: Pulmonary Alveolar Proteinosis, Autoimmune
Interventions: DRUG: Sargramostim|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chromoendoscopy for Dysplasia Detection in Chronic Inflammatory Bowel Disease
Status: UNKNOWN
Conditions: Ulcerative Colitis|Crohn's Colitis
Interventions: PROCEDURE: Colonoscopy with Indigo-Carmine chromoendoscopy|PROCEDURE: Conventional white-light colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of a Dry Powder Aerosol Dispersion Mechanism by Radiolabeling Techniques
Status: COMPLETED
Conditions: Adult Healthy Volunteers
Interventions: DEVICE: modified Handihaler DPI|DEVICE: standard Handihaler DPI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Atomoxetine vs Placebo in the Treatment of ADHD in Swedish Children and Adolescents
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Atomoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficiency of Method of Exosome Inhalation in COVID-19 Associated Pneumonia
Status: UNKNOWN
Conditions: Covid19|SARS-CoV-2 PNEUMONIA|COVID-19
Interventions: DRUG: EXO 1 inhalation|DRUG: EXO 2 inhalation|DRUG: Placebo inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: The Role of the Brain in Mental and Physical Fatigue
Status: RECRUITING
Conditions: Fatigue
Interventions: DRUG: Reboxetine Pill|DRUG: Methylphenidate Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lorcaserin for Cannabis Use Disorder
Status: TERMINATED
Conditions: Cannabis Use Disorder
Interventions: DRUG: Lorcaserin|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Observational Study to Identify New Health Problems Arising After an Intensive Care Unit Admission in People With Acute Respiratory Distress Syndrome in the United States
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Respiratory Distress Syndrome (ARDS)|Post Intensive Care Syndrome (PICS)
Interventions: OTHER: An ICU admission and a temporally related ARDS diagnosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Mild and Subthreshold Depressive Disorders
Status: UNKNOWN
Conditions: Depression
Interventions: DRUG: Sertralin|BEHAVIORAL: Cognitive-behavioral therapy|DRUG: Placebo|BEHAVIORAL: Non-specific supporting group therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Assessing Perceptions and Preferences Around Long-acting Injectables (APPLI)
Status: ACTIVE_NOT_RECRUITING
Conditions: Hiv
Interventions: BEHAVIORAL: Health education materials|BEHAVIORAL: Patient-provider decision tool
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Parturient Controlled Epidural Analgesia (PCEA) With or Without a Basal Infusion for Early Labor
Status: WITHDRAWN
Conditions: Labor Pain
Interventions: OTHER: No Basal Infusion|OTHER: Basal infusion|DRUG: PCEA solution (bupivacaine and fentanyl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Chlorhexidine Toothpaste on Wound Healing After Impacted Tooth Extraction
Status: COMPLETED
Conditions: Tooth Impaction|Tooth Diseases
Interventions: PROCEDURE: Surgery of impacted mandibular wisdom teeth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Safety and Efficacy Study of Travoprost 0.004% Compared to Latanoprost 0.005% in Patients With Open-Angle Glaucoma (OAG) or Ocular Hypertension (OHT)
Status: COMPLETED
Conditions: Glaucoma, Open-Angle|Ocular Hypertension
Interventions: DRUG: Travoprost|DRUG: Latanoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Biofunctionalization of a Volume-stable Collagen Matrix (VCMX) for the Treatment of Single Gingival Recession
Status: RECRUITING
Conditions: Gingival Recession
Interventions: PROCEDURE: CAF|PROCEDURE: i-PRF|DEVICE: VCMX|DRUG: Sodium dipyrone|DRUG: Chlorhexidine rinse|DRUG: Amoxicillin 500mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of TT-00420 (Tinengotinib) in Cholangiocarcinoma
Status: COMPLETED
Conditions: Cholangiocarcinoma|FGFR2 Fusion|FGFR2 Gene Mutation|FGFR1 Alteration|FGFR3 Alteration
Interventions: DRUG: TT-00420
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Forging Sustainable Solutions for HIV Continuity of Care Through Medical-legal Partnerships
Status: RECRUITING
Conditions: Organizational Partnerships for Healthy Living|Standard of Care
Interventions: BEHAVIORAL: Organizational Partnerships for Healthy Living|BEHAVIORAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REGENETEN™ Bioinductive Implant System in Full-thickness Tears
Status: TERMINATED
Conditions: Rotator Cuff Injuries
Interventions: DEVICE: Arthroscopic rotator cuff repair with REGENETEN™ Bioinductive Implant augmentation|PROCEDURE: Arthroscopic rotator cuff repair|DEVICE: Arthroscopic rotator cuff repair for revision surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gene and Protein Expression Patterns in Predicting Response to Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Cancer
Status: TERMINATED
Conditions: Head and Neck Cancer
Interventions: GENETIC: DNA and tissue microarray analysis|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: mass spectrometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Premedication With Alprazolam and Midazolam for Upper Gastrointestinal Endoscopy
Status: COMPLETED
Conditions: Diagnostic Esophagogastroduodenoscopy
Interventions: DRUG: Sublingual alprazolam|DRUG: Oral midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intra-operative Infra-red Fluorescent Imaging in Thyroid and Parathyroid Surgery
Status: COMPLETED
Conditions: Total Thyroidectomy|Bilateral Neck Exploration for Primary Hyperparathyroidism
Interventions: OTHER: MB and fluorescent imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Graded Motor Imagery Training Paradigm on Shoulder Pain
Status: UNKNOWN
Conditions: Stroke, Complication
Interventions: OTHER: Graded motor imagery training paradigm|OTHER: conventional therapy (task-oriented active/passive range of motion training)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a New Multiplex Quantitative PCR Technique for the Diagnosis of Echinococcosis
Status: RECRUITING
Conditions: Echinococcosis|Diagnosis
Interventions: BIOLOGICAL: Blood sample for multiplex QPCR technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sinupret Extract Coated Tablets in Chronic Rhinosinusitis
Status: COMPLETED
Conditions: Chronic Rhinosinusitis
Interventions: DRUG: Sinupret extract coated tablets|DRUG: Placebo coated tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Nicotine Addiction in Adolescent Smokers
Status: COMPLETED
Conditions: Nicotine Dependence, Cigarettes|Cessation, Tobacco|Cessation, Smoking|Adolescent Problem Behavior
Interventions: BEHAVIORAL: Board Game|BEHAVIORAL: Tobacco Cesseation Education|BEHAVIORAL: Combined İntervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Autologous Outer-Root-Sheath Melanocytes Transplantation in the Treatment of Vitiligo
Status: TERMINATED
Conditions: Vitiligo
Interventions: BIOLOGICAL: Outer-Root-Sheath Melanocytes Suspension|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Matcha Green Tea Effects at Rest and During Moderate-intensity Exercise in Females
Status: COMPLETED
Conditions: No Condition
Interventions: DIETARY_SUPPLEMENT: Matcha green tea|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ibrutinib Combination Therapy in Transplant Ineligible Individuals With Newly Diagnosed Primary CNS Lymphoma
Status: RECRUITING
Conditions: Non-hodgkin Lymphoma
Interventions: DRUG: Methotrexate|DRUG: Rituximab (where available)|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Impact of PROximity Support for Patients With Type 1 DIABetes Treated With an Insulin Pump or Closed Loop.
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1
Interventions: OTHER: enhanced care model provided by Timkl, a home support provider
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 2 Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction
Status: COMPLETED
Conditions: Cardiomyopathy, Hypertrophic Obstructive|Left Ventricular Outflow Tract Obstruction
Interventions: DRUG: MYK-461
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kindness Interventions in Enhancing Well-Being in Breast Cancer Survivors
Status: COMPLETED
Conditions: Cancer Survivor|Stage 0 Breast Cancer AJCC v6 and v7|Stage I Breast Cancer AJCC v7|Stage IA Breast Cancer AJCC v7|Stage IB Breast Cancer AJCC v7|Stage II Breast Cancer AJCC v6 and v7|Stage IIA Breast Cancer AJCC v6 and v7|Stage IIB Breast Cancer AJCC v6 and v7|Stage IIIA Breast Cancer AJCC v7
Interventions: BEHAVIORAL: Behavioral Intervention|BEHAVIORAL: Behavioral Intervention|BEHAVIORAL: Behavioral Intervention|BEHAVIORAL: Behavioral Intervention|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Post-op Outcomes of Enhanced Energy Delivery Dissection for Mastectomy With Immediate Breast Reconstruction
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: PROCEDURE: Mastectomy with PhotonBlade|PROCEDURE: Mastectomy with Bovie
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of LY3819469 in Participants With Elevated Lipoprotein(a) [Lp(a)]
Status: ACTIVE_NOT_RECRUITING
Conditions: Lipoprotein Disorder
Interventions: DRUG: LY3819469|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Central Sensitization on Efficacy of Patient-controlled Epidural Analgesia in Osteoarthritis Patients Undergoing Total Knee Replacement
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: CSI score < 40|PROCEDURE: CSI score ≥ 40
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of the DANA to the ANAM in the Evaluation of Cognitive Changes After Concussion
Status: COMPLETED
Conditions: Traumatic Brain Injury|Brain Concussion
Interventions: DEVICE: DANA Brief|OTHER: ANAM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Regional Nasal Block and Dexmedetomidine in Endoscopic Sinus Surgery
Status: UNKNOWN
Conditions: Drug Use
Interventions: DRUG: Bupivacaine HCl 0.5% Injectable Solution|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dose Ranging Study of Rimegepant (BMS-927711) for the Acute Treatment of Migraine
Status: COMPLETED
Conditions: Migraine|Acute Treatment of Migraine
Interventions: DRUG: Rimegepant|DRUG: Placebo|DRUG: Sumatriptan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT