pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Nivolumab in Combination With Temozolomide and Radiotherapy in Children and Adolescents With Newly Diagnosed High-grade Glioma
Status: UNKNOWN
Conditions: High Grade Glioma
Interventions: DRUG: Nivolumab|DRUG: Temozolomide|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contraceptive Hormones and Women With Cystic Fibrosis
Status: TERMINATED
Conditions: Cystic Fibrosis Exacerbations While on and Off Hormonal Contraception
Interventions: OTHER: Non-hormonal period|DRUG: Ortho-cyclen, Ethinyl estradiol/norgestimate, 0.035 mg/0.250 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Acupuncture in Postoperative Pain Control for Minimal Invasive Thoracoscopic Surgery Patients
Status: UNKNOWN
Conditions: Acupuncture|Pain Control|Randomized Controlled Trial|Thoracic Surgery
Interventions: PROCEDURE: Sham Acupuncture|PROCEDURE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Kinesio Taping on Pulmonary Function and Functional Capacity in Patients With Chronic Heart Failure
Status: COMPLETED
Conditions: Chronic Heart Failure
Interventions: DEVICE: Kinesio Tape|DEVICE: Threshold Inspiratory Muscle Trainer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Augmented Reality-Assisted Bonding Versus Digitally-Assisted Indirect Bonding in Orthodontic Patients
Status: NOT_YET_RECRUITING
Conditions: Augmented Reality
Interventions: DEVICE: Augmented Reality-Assisted Indirect Bonding|DEVICE: Digitally-Asssited Indirect Bonding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Comparative Study to Evaluate the Efficacy and Safety of MYL-1701P and Eylea® in Subjects With Diabetic Macular Edema (DME)
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: MYL-1701P|DRUG: Eylea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate The Effects Of Celecoxib (Celebrex®) Or Naproxen On Blood Pressure In Pediatric Subjects
Status: COMPLETED
Conditions: Arthritis, Juvenile Rheumatoid
Interventions: DRUG: Celecoxib|DRUG: Naproxen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acetyl Hexapeptide-8 for Blepharospasm
Status: TERMINATED
Conditions: Focal Dystonia
Interventions: DRUG: Topical acetyl hexapeptide-8|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sym004 in Combination With FOLFIRI in Metastatic Colorectal Cancer Patients
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Sym004|DRUG: FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stress Reduction in Older Women With Stage II, Stage III, or Stage IV Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Psychosocial Effects of Cancer and Its Treatment
Interventions: PROCEDURE: psychosocial assessment and care|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Safety & Efficacy of Intramyocardial Injection of Mesenchymal Precursor Cells on Myocardial Function in LVAD Recipients
Status: COMPLETED
Conditions: Heart Failure|Cardiomyopathy|Ventricular Dysfunction
Interventions: BIOLOGICAL: MPC Intramyocardial Injection|DRUG: Control Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Artemisinin-based Combination Therapy-Intermittent Preventive Treatment (ACT-IPT) Trial Among Schoolchildren in Kassena-Nankana, Ghana
Status: UNKNOWN
Conditions: Malaria|Schistosomiasis|Helminthiasis|Anemia|Change in Sustained Attention
Interventions: DRUG: Artemether-lumefantrine combination plus albendazole|DRUG: Artemether-lumefantrine plus Praziquantel plus Albendazole|DRUG: Albendazole plus Praziquantel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: AMP-224, a PD-1 Inhibitor, With Stereotactic Body Radiation Therapy in Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Colorectal Neoplasms|Colorectal Carcinoma
Interventions: DRUG: AMP-224|RADIATION: Stereotactic Body Radiation Therapy(SBRT)|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Surgery Versus Traditional Open Surgery In The Treatment Of Single Level Lumbar Stenosis
Status: WITHDRAWN
Conditions: Intervertebral Disc Degeneration|Lumbar Spinal Stenosis
Interventions: DEVICE: Lumbar fusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Adjuvant IFN-α for Patients Underwent Curative Surgery for HCC With a Low miR-26 Expression
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: interferon-alpha (IFN-alpha)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medication Strategies for Treating Aggressive Behavior in Youth With Attention Deficit Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity|Conduct Disorder|Oppositional Defiant Disorder
Interventions: DRUG: Divalproex Sodium|DRUG: Methylphenidate|DRUG: Dextroamphetamine|DRUG: Mixed Amphetamine Salts|BEHAVIORAL: Family Counseling|BEHAVIORAL: Behavior Management Training with Parents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Fractional CO2 Laser Combined With Intralesional Insulin, Botulinum Toxin or Triamcinolone Acetonide in the Treatment of Keloid: A Clinical, Dermoscopic and Immunohistochemical Study.
Status: NOT_YET_RECRUITING
Conditions: Keloid
Interventions: DRUG: Insulin group|DRUG: Botulinum toxin group|DRUG: Triamcinolone acetonide group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Sufentanil on the Postoperative Pain
Status: NOT_YET_RECRUITING
Conditions: Postoperative Pain, Acute
Interventions: DRUG: Sufentanil|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Project 2 Cigarette and E-cigarette Nicotine Content and E-liquid Flavors
Status: COMPLETED
Conditions: Smoking
Interventions: OTHER: NNC Spectrum Cigarette|OTHER: VLNC Spectrum Cigarette|OTHER: Moderate nicotine level e-liquid|OTHER: Low nicotine level e-liquid|OTHER: Tobacco Flavors|OTHER: Tobacco and non-tobacco e-liquid flavors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Axi-Cel as a 2nd Line Therapy in Patients With Relapsed/Refractory Aggressive B Lymphoma Ineligible to Autologous Stem Cell Transplantation
Status: ACTIVE_NOT_RECRUITING
Conditions: B-Cell Lymphoma Refractory|B-cell Lymphoma Recurrent
Interventions: DRUG: axicabtagene ciloleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Topical Anesthetic Containing Lidocaine and Prilocaine in Treatment With CO2 Fractional Laser
Status: COMPLETED
Conditions: Lidocaine Adverse Reaction|Prilocaine Adverse Reaction
Interventions: DRUG: Lidocaine / Prilocaine Cream|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intravenous Tranexamic Acid and Interscalene Block Applied on Shoulder Arthroscopy
Status: UNKNOWN
Conditions: Nerve Block|Tranexamic Acid
Interventions: OTHER: interscalene block|DRUG: tranexamic acid|OTHER: general anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Gemcitabine/Platinum +/- Cetuximab as First-Line Treatment for Patients With Advanced/Metastatic Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small-Cell Lung Carcinoma
Interventions: DRUG: Cetuximab + platinum + gemcitabine|DRUG: Platinum + Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arresting Carious Lesions With Minimal Intervention Techniques
Status: NOT_YET_RECRUITING
Conditions: Caries,Dental
Interventions: OTHER: BRIX3000®|OTHER: Riva Star Aqua, SDI Limited, Australia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Group Study to Evaluate the Effects of a Multivitamin on a Range of Health and Wellbeing Outcomes.
Status: ACTIVE_NOT_RECRUITING
Conditions: Health and Wellbeing
Interventions: DIETARY_SUPPLEMENT: Multivitamin Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Yttrium Y 90 Ibritumomab Tiuxetan and Rituximab in Treating Patients With Post-Transplant Lymphoproliferative Disorder
Status: COMPLETED
Conditions: Post-transplant Lymphoproliferative Disorder|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Waldenström Macroglobulinemia
Interventions: BIOLOGICAL: rituximab|RADIATION: indium In 111 ibritumomab tiuxetan|RADIATION: yttrium Y 90 ibritumomab tiuxetan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Eribulin in Combination With Bevacizumab for Second-line Treatment HER2- MBC Patients
Status: UNKNOWN
Conditions: Metastatic Breast Cancer|Human Epidermal Growth Factor 2 Negative Carcinoma of Breast
Interventions: DRUG: Bevacizumab and eribulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Human Bone Marrow Mesenchymal Stem Cells in aPAP
Status: NOT_YET_RECRUITING
Conditions: Autoimmune Pulmonary Alveolar Proteinosis
Interventions: DRUG: human Bone Marrow Mesenchymal Stem Cell (hBMMSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Reiki and Acupressure on Pain, Anxiety and Vital Signs
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: OTHER: Acupressure|OTHER: Reiki
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Uncemented Tritanium Compared With Cemented Metal-backed Tibia Components in Total Knee Replacement
Status: ACTIVE_NOT_RECRUITING
Conditions: Arthroplasty|Replacement|Knee
Interventions: DEVICE: Uncemented Triathlon Tritanium CR Total Knee System|DEVICE: Cemented Triathlon CR Total Knee System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Polyamine-enriched Diet in Healthy Older Adults With Subjective Cognitive Decline
Status: COMPLETED
Conditions: Subjective Cognitive Decline
Interventions: DIETARY_SUPPLEMENT: Polyamine supplementation|DIETARY_SUPPLEMENT: Placebo supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Delivering Transcutaneous Auricular Neurostimulation to Regulate Platelet Activity in Healthy Human Subjects
Status: RECRUITING
Conditions: Hemostasis|Blood Biomarkers
Interventions: DEVICE: Volta System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Safety and Efficacy Study of Relamorelin in Diabetic Gastroparesis Study 04
Status: TERMINATED
Conditions: Gastroparesis|Diabetes Mellitus
Interventions: DRUG: Placebo|DRUG: Relamorelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Antibiotics on Urinary Microbiome
Status: WITHDRAWN
Conditions: Microtia|UTI|Bacteriuria|Antibiotic Resistant Infection|Antibiotics Causing Adverse Effects in Therapeutic Use
Interventions: DRUG: Bactrim DS 800Mg-160Mg Tablet|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Investigation of Cardioversion Versus Therapeutic Ablation for Persistent AF (ORBICA-AF)
Status: RECRUITING
Conditions: Persistent Atrial Fibrillation|Cardiac Arrhythmia|Catheter Ablation
Interventions: PROCEDURE: Pulmonary vein isolation|PROCEDURE: DC Cardioversion|DEVICE: Implantable loop recorder|PROCEDURE: Femoral sheath insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Maternal Adherence to MMS in Nepal
Status: NOT_YET_RECRUITING
Conditions: Supplementation|Pregnancy Related|Postnatal Related
Interventions: DRUG: Multiple Micronutrient Supplement Blister|DRUG: Multiple Micronutrient Supplement Bottle|DRUG: Iron Folic Acid Blister
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Feasibility or Oral Lactoferrin to Prevent Iron Deficiency Anemia in Obese Pregnancy
Status: ENROLLING_BY_INVITATION
Conditions: Iron-deficiency|Pregnancy Anemia|Obesity
Interventions: DIETARY_SUPPLEMENT: Jarrow Formulas Oral Bovine Lactoferrin Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of eHealth on AB Use of Children With Acute, Uncomplicated URTIs
Status: NOT_YET_RECRUITING
Conditions: Upper Respiratory Tract Infection
Interventions: DEVICE: FeverApp|DEVICE: DMT App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Error Augmentation Motor Learning Training Approach in Stroke Patients
Status: UNKNOWN
Conditions: Stroke Rehabilitation|Cerebrovascular Stroke|Muscle Spasticity|Upper Extremity Paresis
Interventions: BEHAVIORAL: Intensive physical rehabilitation type training|DEVICE: Robotic system for supporting and monitoring arm motion|DEVICE: Actigraph Activity Monitor|DIAGNOSTIC_TEST: Magnetic resonance imaging (MRI)|DIAGNOSTIC_TEST: Montreal Spasticity Measure (MSM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Biomarker Study
Status: RECRUITING
Conditions: Migraine|Cluster Headache|Trigeminal Autonomic Cephalgia|Hemicrania Continua|Paroxysmal Hemicrania|SUNCT|Short-Lasting Unilateral Neuralgiform Headache With Conjunctival Injection and Tearing
Interventions: DRUG: Oral capsaicin|DRUG: Topical capsaicin|DRUG: Intranasal capsaicin|OTHER: Cold Water Irrigation|OTHER: Medical Air|DRUG: Low Flow Oxygen|DRUG: High Flow Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Vehicle-controlled Study of Topical MOB015B in the Treatment of Distal Subungual Onychomycosis (DSO)
Status: ACTIVE_NOT_RECRUITING
Conditions: Onychomycosis
Interventions: DRUG: MOB015B|DRUG: Vehicle (Placebo Comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carboxyamidotriazole + RT in Treating Patients Newly Diagnosed Supratentorial GBM
Status: COMPLETED
Conditions: Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma
Interventions: RADIATION: radiation therapy|DRUG: carboxyamidotriazole|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Circulating Microvesicles Regulating Metabolic Homeostasis in Obesity After Caloric Restriction Programs
Status: NOT_YET_RECRUITING
Conditions: Obesity
Interventions: BEHAVIORAL: Active Comparator: Continuous calorie restriction|BEHAVIORAL: eTRE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Attentional Filter Training on Working Memory
Status: COMPLETED
Conditions: Cognitive Decline|Healthy|Age-related Cognitive Decline
Interventions: BEHAVIORAL: filter training|BEHAVIORAL: memory training|OTHER: no training (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Pasteurised Akkermansia Muciniphila in Healthy Medical Workers
Status: RECRUITING
Conditions: Stress|Healthy|Dietary Supplement
Interventions: DIETARY_SUPPLEMENT: Pasteurized Akkermansia muciniphila|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Morphine Mouthwash for Management of Oral Mucositis in Patients With Head and Neck Cancer
Status: COMPLETED
Conditions: Stomatitis
Interventions: DRUG: 2% morphine solution|DRUG: Magnesium aluminum hydroxide|DRUG: 2% viscous lidocaine|DRUG: Diphenhydramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Genetic Disorders of Mucociliary Clearance in Nontuberculous Mycobacterial Lung Disease
Status: COMPLETED
Conditions: Cystic Fibrosis|Pseudohypoaldosteronism|Nontuberculous Mycobacterial Infection|Chronic Granulomatous Disease|Primary Ciliary Dyskinesia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Enhancement of Physical and Combat Preparedness of SAF Members
Status: COMPLETED
Conditions: Physical Fitness|Combat Readiness|Injury Prevention|Validation of Testing Batteries
Interventions: OTHER: Strength and Conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate D-1553 in Combination With IN10018 in Subjects With Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: D-1553|DRUG: IN10018
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Efficacy and Safety of Inhaled GB0139 in Subjects With Idiopathic Pulmonary Fibrosis (IPF)
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis (IPF)
Interventions: DRUG: GB0139|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Protein-Restricted Diet on Nitrogen Balance and Residual Renal Function in Peritoneal Dialysis (PD) Patients
Status: COMPLETED
Conditions: Chronic Kidney Disease|Peritoneal Dialysis
Interventions: DIETARY_SUPPLEMENT: diets contained different levels of protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1b/2 Study of Retaspimycin HCl (IPI-504) in Combination With Everolimus in KRAS Mutant Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: IPI-504|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Durvalumab Alone and Durvalumab+Olaparib in Advanced, Platinum-Ineligible Bladder Cancer (BAYOU)
Status: ACTIVE_NOT_RECRUITING
Conditions: Urinary Bladder Neoplasms
Interventions: DRUG: Durvalumab|DRUG: Olaparib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tamoxifen Versus Anastrozole, Alone or in Combination With Zoledronic Acid
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: tamoxifen|DRUG: anastrozole|DRUG: zoledronic acid|OTHER: goserelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-surgical Antisepsis Using an Alcoholic Solution of Chlorhexidine Digluconate and Potassium Sorbate ( Sorbectol )
Status: UNKNOWN
Conditions: Antisepsis
Interventions: DRUG: Hand antisepsis with Propanolol- 1 60%.|DRUG: Hand antisepsis with a solution of alcohol, chlorhexidine digluconate and potassium sorbate.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diabetic Retinopathy Tethered Augmented Reality With Eye4 Study
Status: COMPLETED
Conditions: Diabetic Retinopathy|Low Vision
Interventions: DEVICE: Eye4|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars
Status: COMPLETED
Conditions: Irreversible Pulpitis
Interventions: DRUG: IANB Articaine|DRUG: SUP Articaine|DRUG: SUP Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect on Orencia (Abatacept) on the Apoptosis of T Cells, B Cells and APC Cells in Rheumatoid Arthritis
Status: WITHDRAWN
Conditions: Apoptotic DNA Damage|Rheumatoid Arthritis|T-cell Lymphocytosis
Interventions: DRUG: Group 1 or Orencia treated group|OTHER: Group 2 (DMARDS treated group)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telemedicine Improves Pain-related Disabilities in Following up Cancer Pain Outpatient
Status: RECRUITING
Conditions: Pain, Chronic|Cancer Pain
Interventions: OTHER: Telemedicine|OTHER: In-person
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Additional Screening With Sensitives RDTs and Malaria
Status: COMPLETED
Conditions: Plasmodium Falciparum Malaria|Malaria Diagnosis
Interventions: DIAGNOSTIC_TEST: Additional screening using ultra sensitive RDTs|DRUG: Dihydroartemisinin-piperaquin|OTHER: Reminders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Performance Assessment of the Decongestant Seawater Spray Pocket Valve Enriched With Essential Oils in Patients With Acute Rhinitis Associated With Nasal Obstruction
Status: RECRUITING
Conditions: Acute Rhinitis|Nasal Obstruction|Rhinosinusitis|Rhinopharyngitis|Allergic Rhinitis
Interventions: DEVICE: Measurement of peak nasal flow.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of CRushed TriUMeq With or Without Drip Feed Compared to the Whole Tablet
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Triumeq|DRUG: Triumeq crushed + breakfast|DRUG: Triumeq crushed + drip feed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Memory-Like Natural Killer Cells With Nivolumab and Relatlimab in Advanced or Metastatic Melanoma After Progression on Checkpoint Inhibitors
Status: NOT_YET_RECRUITING
Conditions: Advanced Melanoma|Metastatic Melanoma
Interventions: BIOLOGICAL: Cytokine-induced memory-like natural killer cells|BIOLOGICAL: Relatilmab|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab
Status: NOT_YET_RECRUITING
Conditions: Depressive Disorder, Major|Inflammation
Interventions: DRUG: Infliximab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Victim Impact Modules for Jail Inmates
Status: WITHDRAWN
Conditions: Substance Abuse|HIV Risk|Shame|Guilt|Empathy|Criminogenic Thinking
Interventions: BEHAVIORAL: Impact of Crime Modules|BEHAVIORAL: TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low Back Pain and Quality of Life Among the Ambulance Drivers in Malaysia's Hospitals
Status: COMPLETED
Conditions: Low Back Pain|Quality of Life
Interventions: BEHAVIORAL: Integrated back pain module (IBPM)|OTHER: Health Educational Pamphlet.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy to Relieve Symptoms in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: RADIATION: Cyclical Hypofractionated Palliative Radiation (Quad Shot)|BEHAVIORAL: EORTC QLQ-C30 questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Study of a Fully Human BCMA-targeting CAR (CT103A) in Patients With Relapsed/Refractory Multiple Myeloma (FUMANBA-1)
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: CT103A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study of ZOSTAVAX Administered by Intramuscular or Subcutaneous Route to Participants Aged From 50 Years Old (V211-045)
Status: COMPLETED
Conditions: Herpes Zoster
Interventions: BIOLOGICAL: ZOSTAVAX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Efficacy, Safety and Effects on Quality of Life of Tramadol/Paracetamol as Add-on Therapy in Chronic Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Tramadol/Paracetamol (APAP)|DRUG: Non-Tramadol/APAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Evaluate the Efficacy and Safety of 60mg of MM-093 in Patients With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: MM-093
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tirelizumab Combined With Chemotherapy in the Treatment of HER-2 Negative Locally Advanced Gastric Cancer
Status: RECRUITING
Conditions: Locally Advanced Gastric Carcinoma|HER2 Negative|Efficacy|Safety
Interventions: DRUG: Tirolizumab+SOX/XELOX|DRUG: SOX/XELOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mentalization - Based Treatment: Adolescents With Co-morbid Depression and Personality Disorder
Status: UNKNOWN
Conditions: Depression|Personality Disorder
Interventions: OTHER: MBT|OTHER: treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Development of a Tool for Optimized Self- and Hetero-diagnosis of Stroke Using Artificial Intelligence: Stage1- Collection of Video-clinical Data in a Pragmatic Situation.
Status: RECRUITING
Conditions: Stroke, Cerebrovascular
Interventions: OTHER: AI-STROKE application
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Project Health: Enhancing Effectiveness of a Dissonance-Based Obesity Prevention Program
Status: ACTIVE_NOT_RECRUITING
Conditions: Overweight and Obesity
Interventions: BEHAVIORAL: Project Health|BEHAVIORAL: Response and Attention Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Noninvasive VNS to Facilitate Excitability in Motor Cortex
Status: ACTIVE_NOT_RECRUITING
Conditions: Stroke|Stroke Sequelae|Motor Activity
Interventions: DEVICE: Transcranial Magnetic Stimulation|DEVICE: transcutaneous auricular vagus nerve stimulation (taVNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase II Trial to Evaluate the Safety and Immunogenicity of BIMERVAX® When Coadministered With Seasonal Influenza Vaccine (SIIV) in Adults Older Than 65 Years of Age Fully Vaccinated Against COVID-19
Status: COMPLETED
Conditions: SARS CoV 2 Infection|Influenza, Human
Interventions: BIOLOGICAL: BIMERVAX|BIOLOGICAL: SIIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Asthma and Obesity: Pilot Study
Status: COMPLETED
Conditions: Asthma|Obesity
Interventions: BEHAVIORAL: Better asthma self-management and incorporation of physical activity|BEHAVIORAL: Asthma Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Therapeutic Strategies With Cholinesterase Inhibitors (SOS TRIAL)
Status: NOT_YET_RECRUITING
Conditions: Alzheimer Disease|Cholinesterase Inhibitors
Interventions: DRUG: cholinesterase inhibitors (CI) (donepezil, galantamine or rivastigmine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of ACZ885 in Patients With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Canakinumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Treatment of Skin Rash Associated With EGFR Inhibitor Therapy
Status: COMPLETED
Conditions: EGFR Inhibitor-Induced Skin Rash
Interventions: DRUG: AC-701 Topical Gel 0.3%|OTHER: Placebo Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Circulating RNAs in Acute Congestive Heart Failure
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Congestive Heart Failure|Heart Failure With Reduced Ejection Fraction|Heart Failure With Normal Ejection Fraction
Interventions: DIAGNOSTIC_TEST: Cardiac MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Role of Sodium Chloride and the Treg/Th17 Axis in Autoimmune Hepatitis
Status: COMPLETED
Conditions: Autoimmune Hepatitis
Interventions: OTHER: Low Salt Diet|OTHER: Liberal salt diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The BENEFICIAL Study: Evaluating the Efficacy and Safety of Alagebrium (ALT-711) in Patients With Chronic Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: ALT-711|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention and Treatment of Immersion Pulmonary Edema
Status: COMPLETED
Conditions: Immersion Pulmonary Edema (IPE)|Swimming Induced Pulmonary Edema (SIPE)
Interventions: DRUG: Sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Serum Retinoic Acid Induced Protein 14 (RAI14) and Metastasis Associated Cancer Colon -1 (MACC-1) in Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DIAGNOSTIC_TEST: laboratory test (RAI14 and MACC-1 )
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Therapy for Pediatric Relapsed or Refractory Precursor B-Cell Acute Lymphoblastic Leukemia and Lymphoma
Status: COMPLETED
Conditions: Recurrent B-Cell Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood B-Lymphoblastic Lymphoma
Interventions: DRUG: dexamethasone|DRUG: vincristine sulfate|BIOLOGICAL: rituximab|DRUG: clofarabine|DRUG: cyclophosphamide|DRUG: etoposide|BIOLOGICAL: aldesleukin|DRUG: pegaspargase|DRUG: methotrexate|DRUG: mercaptopurine|DRUG: cytarabine|DRUG: mitoxantrone|DRUG: teniposide|DRUG: vinblastine|BIOLOGICAL: natural killer cell infusion|OTHER: laboratory biomarker analysis|DRUG: therapeutic hydrocortisone|PROCEDURE: allogeneic hematopoietic stem cell transplantation|DEVICE: CliniMACS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contribution of Percutaneous Endoscopic Caecostomie in the Management of Severe Constipation Refractory to Medical Treatment
Status: COMPLETED
Conditions: Constipation
Interventions: DEVICE: Chait Trapdoor caecostomie catheter|DRUG: continuation of optimal medical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optokinetic Virtual Reality Stimulation in Unilateral Vestibular Hypofunction
Status: RECRUITING
Conditions: Vestibular Hypofunction
Interventions: OTHER: Optokinetic Virtual Reality Stimulation|OTHER: Conventional rehabilitation program based on Cawthorne Cooksey exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Monitoring Patients With Severe Obesity Treated With Wegovy® Using Connected Device: Real-world Data
Status: NOT_YET_RECRUITING
Conditions: Obesity
Interventions: DEVICE: Withings Body Comp Pro
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Impact of a Personalized Medication Plan on Duration of Treatment With Potent Opioids in Acute Non-cancer Musculoskeletal Pain.
Status: RECRUITING
Conditions: Acute Pathology of the Locomotor System
Interventions: OTHER: personalized pharmaceutical plan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Examine the Clinical Efficacy and the Nonsteroidal Anti-inflammatory Drug (NSAID)-Sparing Effect of Secukinumab Over 16 Weeks in Patients With Ankylosing Spondylitis
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: DRUG: Secukinumab (AIN457) 150 mg s.c.|DRUG: Secukinumab (AIN457) 150 mg s.c.|DRUG: Placebo - Secukinumab (AIN457) 150 mg s.c.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DRUG: Inclisiran sodium 300 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Inactivated Shigella Whole Cell Vaccine in Adults
Status: COMPLETED
Conditions: Shigellosis
Interventions: BIOLOGICAL: Vaccine: 2.6±0.8 x 10^8 vp/mL, 1 dose|BIOLOGICAL: Vaccine: 2.6±0.8 x 10^9 vp/mL, 3 doses|BIOLOGICAL: Vaccine: 2.6±0.8 x 10^10 vp/mL, 3 doses|BIOLOGICAL: Vaccine: 2.6±0.8 x 10^11 vp/mL, 3 doses|BIOLOGICAL: Placebo: 1-3 doses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Feedback Regarding Illness Behavior on Patient Satisfaction in Hand Surgery
Status: COMPLETED
Conditions: Hand Surgery
Interventions: OTHER: PROMIS CAT Pain Interference|OTHER: PROMIS CAT Pain Behavior|OTHER: PROMIS CAT Physical Function|OTHER: MISS-21
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparing HHHFNC and nCPAP Ventilation Methods for the Prevention of Extubation Failure in Preterm Infants
Status: UNKNOWN
Conditions: Extubation Failure|Prematurity
Interventions: DEVICE: Heated Humidified High-Flow Nasal Cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: α-TEA in Advanced Cancer
Status: COMPLETED
Conditions: Metastatic Carcinoma|Metastatic Sarcoma|Metastatic Lymphoma
Interventions: DRUG: 2.4 mg/kg α-TEA|DRUG: 4.8 mg/kg α-TEA|DRUG: 8.0 mg/kg α-TEA|DRUG: 9.6 mg/kg α-TEA|DRUG: 12 mg/kg α-TEA|DRUG: 16.8 mg/kg α-TEA|DRUG: 19.2 mg/kg α-TEA|DRUG: 22.3 mg/kg α-TEA|DRUG: 26.8 mg/kg α-TEA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Nevirapine on the Steady State Pharmacokinetics of Fluconazole in HIV Positive Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Fluconazole|DRUG: Nevirapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bimanual Motor Skill Learning in Acute Stroke
Status: RECRUITING
Conditions: Stroke, Acute|Stroke, Subacute
Interventions: DEVICE: REAplan®|DEVICE: Dextrain Manipulandum®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment With Copper in Patients With Mild Alzheimer´s Dementia
Status: COMPLETED
Conditions: Alzheimer´s Disease
Interventions: DIETARY_SUPPLEMENT: copper|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Community Transmission of Sabin Type 2 Virus in Bangladesh
Status: UNKNOWN
Conditions: Vaccine Virus Shedding
Interventions: BIOLOGICAL: tOPV|BIOLOGICAL: bOPV|BIOLOGICAL: IPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pneumatic Retinopexy for Severe Bullous Retinal Detachment
Status: COMPLETED
Conditions: Retina Detachment
Interventions: PROCEDURE: Scleral Buckling|PROCEDURE: Drainage-Injection-Pneumoretinopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Immunological Changes and Clinical Efficacy of Specific Immunotherapy With Der p House Dust Mite Allergen in Polysensitized and Monosensitized Patients With Allergic Rhinitis and/or Asthma.
Status: UNKNOWN
Conditions: Allergen Immunotherapy, Immunological Mechanisms,Monosensitized,Polysensitized,Clinical Efficacy
Interventions: OTHER: Allergen specific immunotherapy and placebo injections
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study for the Effects of Microcurrent Therapy on the Prevention and Healing of Brachioplasty Scars
Status: COMPLETED
Conditions: Cicatrix
Interventions: DEVICE: Microcurrent therapy|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Significance of Heterozygosity for Mutations of the SLC12A3 Gene Coding for the Thiazide Sensitive Na-Cl Cotransporter
Status: COMPLETED
Conditions: Heterozygous Carriers of Gitelman Syndrome
Interventions: PROCEDURE: Samplings of blood|PROCEDURE: Sampling of urine|PROCEDURE: Measure of the blood pressure|PROCEDURE: glycemia test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intraoperative Neuromonitoring of Pelvic Autonomous Nerve Plexus During Total Mesorectal Excision
Status: RECRUITING
Conditions: Rectal Neoplasms
Interventions: OTHER: Pelvic Intraoperative Neuromonitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Androgen Deprivation, With or Without pTVG-AR, and With or Without T-Cell Checkpoint Blockade, in Patients With Newly Diagnosed, High-Risk Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Degarelix|BIOLOGICAL: pTVG-AR|DRUG: Nivolumab|DRUG: Cemiplimab|DRUG: Fianlimab|DRUG: FLT PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of TAK-816 in Healthy Infants
Status: COMPLETED
Conditions: Immunization
Interventions: BIOLOGICAL: TAK-816+ DPT-TAKEDA|BIOLOGICAL: ActHIB+ DPT-TAKEDA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety of MIN-117 in Adult Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: MIN-117 5.0 mg|DRUG: MIN-117 2.5 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Combination of Rituximab and Varlilumab Immunotherapy in Patients With B-cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: B Cell Lymphoma
Interventions: DRUG: Varlilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Music Based Caregiving in Patients With Pain and Dementia
Status: COMPLETED
Conditions: Pain|Dementia|Music|Activity, Motor|Quality of Life
Interventions: BEHAVIORAL: Music based caregiving
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Nasal Glucagon for Treatment of Hypoglycemia in Adults
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Nasal Glucagon|DRUG: Intramuscular Glucagon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Early Mobilization Protocol in Patients in the ICU
Status: COMPLETED
Conditions: Muscle Weakness|Quality of Life|Weaning Acceleration|ICU Length of Stay|Muscle Thickness of the Quadriceps Femoris
Interventions: OTHER: Early mobilization protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Can a Person-centred-care Intervention Improve Health-related Quality of Life in Patients With Head and Neck Cancer
Status: COMPLETED
Conditions: Health Related Quality of Life
Interventions: OTHER: gPCC (Gothenburg Person Centred Care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE