pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of INDUS810 on Body Composition, Muscular Performance, and Training Adaptations
Status: COMPLETED
Conditions: Weakness, Muscle
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Indus810
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characterization of Olfactory Perception in Post-Traumatic Stress Disorder
Status: NOT_YET_RECRUITING
Conditions: Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: European Test of Olfactory Capabilities (ETOC)|BEHAVIORAL: Standardized Hedonicity Test|BEHAVIORAL: Questionnaires|BEHAVIORAL: Odor / trauma association questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Twice Daily Titration Study of Bifeprunox in Subjects With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Bifeprunox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: This Study Tests Empagliflozin in Patients With Chronic Heart Failure With Preserved Ejection Fraction (HFpEF). The Study Looks at How Far Patients Can Walk in 6 Minutes and at Their Heart Failure Symptoms.
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Empagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Phenoximethylpenicillin, Amoxicillin and Amoxicillin-clavulanic Acid on the Gut Microbiota
Status: COMPLETED
Conditions: Infectious Disease
Interventions: DRUG: Phenoxymethylpenicillin|DRUG: Amoxicillin|DRUG: Amoxicillin-clavulanic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Two Dose Schedules of Panitumumab in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Tumors|Oncology|Solid Tumors
Interventions: DRUG: panitumumab (ABX-EGF)|DRUG: Panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Oncologic Outcomes of Robotic Versus Laparoscopic Total Gastrectomy for Advanced Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: PROCEDURE: Robotic-assisted Total Gastrectomy with D2 Lymphadenectomy|PROCEDURE: Laparoscopic-assisted Total Gastrectomy with D2 Lymphadenectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Salmeterol Inhalation Powder Administered as the Xinafoate Salt From Hard Polyethylene Capsules Via the HandiHaler® 2, and Serevent® Diskus® in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Salmeterol medium dose|DRUG: Salmeterol low dose|DRUG: Salmeterol high dose|DRUG: Serevent® Diskus®|DRUG: Placebo HandiHaler®|DRUG: Placebo Diskus®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of the Visual Performance of Trifocal Versus Extended Depth of Focus Intraocular Lenses
Status: UNKNOWN
Conditions: Cataract|Lenses|Visual Impairment
Interventions: DEVICE: Intraocular lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dual Antithrombotic Therapy With Dabigatran and Ticagrelor in Patients With ACS and Non-valvular AF Undergoing PCI
Status: RECRUITING
Conditions: Atrial Fibrillation|Antithrombotic Therapy|Acute Coronary Syndrome|Percutaneous Coronary Interventions
Interventions: DRUG: Ticagrelor|DRUG: Dabigatran Etexilate|DRUG: Aspirin|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravoxel Incoherent Motion (IVIM) Magnetic Resonance Imaging in Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis
Interventions: OTHER: Diffusion-weighted magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: VoIP Delivered Behavior Therapy for Tourette Syndrome
Status: COMPLETED
Conditions: Tourette Syndrome|Chronic Tic Disorder
Interventions: BEHAVIORAL: Behavior Therapy for Tics (CBIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Effect of Synbiotics in Patients With Pre-diabetes
Status: COMPLETED
Conditions: PreDiabetes
Interventions: DIETARY_SUPPLEMENT: Metabolic Rheostat|DIETARY_SUPPLEMENT: Butyrate Ultra|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Buspirone Hydrochloride 30mg Tablets, Fasting
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BUSPAR® 30 mg Tablet|DRUG: Buspirone Hydrochloride 30 mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Radiographic Assessment of Glass Ionomer Restorations With and Without Prior Application of Nano Silver Fluoride in Occlusal Carious Molars Treated With Partial Caries Removal Technique
Status: COMPLETED
Conditions: Partial Dentin Caries Removal
Interventions: OTHER: nano silver fluoride solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LUT014 in Patients With Metastatic Colorectal Cancer With EGFR Inhibitor Induced Acneiform Lesions
Status: COMPLETED
Conditions: EGFR Inhibitor Induced Acneiform Lesions
Interventions: DRUG: LUT014
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Neoadjuvant Docetaxel and Cisplatin for Resectable Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small-Cell Lung Carcinoma
Interventions: DRUG: Neoadjuvant Therapy with Cisplatin Plus Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Transcutaneous Vagal Nerve Stimulation Improves Fear Extinction in Humans
Status: UNKNOWN
Conditions: Healthy Adults
Interventions: DEVICE: t-VNS|DEVICE: sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Supervised Manual Physical Therapy Exercise for Ankle Disability After Motor Vehicle Accidents.
Status: COMPLETED
Conditions: Ankle Deformity
Interventions: OTHER: Supervised physical therapy manual exercise program.|OTHER: Stretching exercise, ROM, Strengthening exercises.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Physiotherapy Protocol in Treating Chronic Rhinosinusitis
Status: COMPLETED
Conditions: Rhinosinusitis
Interventions: OTHER: Ultrasound Therapy|OTHER: Manual Drainage Techniques|OTHER: Self Sinus Massage Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study Comparing Carelizumab Plus Nab-paclitaxel and Apatinib, Carelizumab Plus Nab-paclitaxel, and Nab-paclitaxel in Patients With Advanced Triple Negative Breast Cancer.
Status: TERMINATED
Conditions: Breast Cancer|Triple Negative Breast Cancer
Interventions: DRUG: Carelizumab|DRUG: Nab-paclitaxel|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Preterm Birth by Screening of the Consistency Index and Length of the Uterine Cervix in Women With a Single Pregnancy
Status: UNKNOWN
Conditions: Pregnancy, High Risk|Preterm Birth|Cervix; Pregnancy|Obstetric Labor, Premature|Obstetric Labor Complications|Pregnancy Complications
Interventions: PROCEDURE: Transvaginal ultrasound cervical length screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Feasibility and Diagnostic Accuracy of Myocardial SPECT Using Early Imaging Protocol
Status: WITHDRAWN
Conditions: Coronary Artery Disease|Atherosclerosis
Interventions: PROCEDURE: Myocardial Perfusion imaging with 10 minute waiting period
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Brexanolone for Acute Respiratory Distress Syndrome (ARDS) Due to Coronavirus Disease 2019 (COVID-19)
Status: TERMINATED
Conditions: Acute Respiratory Distress Syndrome|COVID-19
Interventions: DRUG: Brexanolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Acetaminophen- Caffeine- Codeine Combination and Anaesthetic Success in Patients With Acute Pulpitis
Status: COMPLETED
Conditions: Symptomatic Irreversible Pulpitis
Interventions: DRUG: Acetaminophen and codeine and caffeine|DRUG: Acetaminophen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Transarterial Radioembolization Versus Chemoembolization for the Treatment of Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: Transarterial Radioembolization|PROCEDURE: Transarterial Chemoembolization using drug-eluting beads
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of TAK-925 Study in Sleep-Deprived Healthy Adults
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: TAK-925|DRUG: TAK-925 Placebo|DRUG: Modafinil|DRUG: Modafinil Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Thromboelastography Guides a Multicentre Cluster Controlled Study of Plasma Exchange for Hepatitis B Associated Acute-on-chronic Liver Failure
Status: UNKNOWN
Conditions: 28 Day Mortality
Interventions: BIOLOGICAL: plasma exchange
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant of Sintilimab Combined Weekly Metronomic Chemotherapy (PLOF) for Resectable Locally Advanced Gastric Cancer
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: sintilimab+metronomic PLOF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neural Mechanisms of Intermittent Theta Burst Stimulation in the Core Depression Network
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DEVICE: Theta burst stimulation|DEVICE: Theta burst stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Darunavir in the Presence of Cobicistat When Administered as a Fixed Dose Combination Compared to the Co-administration of the Separate Available Formulations of Darunavir and Cobicistat Under Fed Conditions in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: DRV/COBI FDC|DRUG: COBI|DRUG: DRV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pharmacodynamic Study Comparing Zegerid® and Prilosec OTC® (Study CL2008-02)(P07814)(COMPLETED)
Status: COMPLETED
Conditions: Gastric Acid|Human Experimentation
Interventions: DRUG: Omeprazole/sodium bicarbonate|DRUG: omeprazole magnesium (20 mg equivalent)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Trial of Fulvestrant, MK-0646, and Dasatinib for Metastatic Hormone Receptor-Positive HER2-Negative Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Fulvestrant|DRUG: MK-0646|DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positive Processes and Transition to Health (PATH)
Status: NOT_YET_RECRUITING
Conditions: Posttraumatic Stress Disorder|Major Depressive Disorder
Interventions: BEHAVIORAL: Positive Processes and Transition to Health|BEHAVIORAL: Progressive Muscle Relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: t-PA Prophylaxis to Prevent Catheter-associated Thrombosis and Infection
Status: COMPLETED
Conditions: Central Venous Catheter Thrombosis|Central Venous Catheter Associated Bloodstream Infection
Interventions: BIOLOGICAL: alteplase (recombinant t-PA)|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of KTE-X19 in Minimal Residual Disease (MRD) Positive B-Cell Acute Lymphoblastic Leukemia (B-ALL)
Status: RECRUITING
Conditions: B-Cell Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia
Interventions: DRUG: Tecartus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: From Benchmark to Surgical Activity: the Role of Endobronchial Fiducial Markers for Ground Glass Lung Nodules Resection.
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer|Lung Non-Small Cell Carcinoma|Lung; Node
Interventions: DEVICE: Tornado (Cook)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sleep Disordered Breathing, Adenotonsillectomy, Cognition and Pre-school Age Children
Status: COMPLETED
Conditions: Sleep Disordered Breathing
Interventions: PROCEDURE: Adenotonsillectomy|DRUG: Watchful waiting with supportive care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics of ASP1707 and Methotrexate in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: ASP1707|DRUG: methotrexate (MTX)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palliative Care and Quality of Life in Idiopathic Pulmonary Fibrosis
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis|Depression|Anxiety|Depressive Disorder|Anxiety Disorders|Anxiety Depression
Interventions: BEHAVIORAL: Palliative Care|BEHAVIORAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amino Acid Profile and Muscle Protein Synthetic Response to Consuming Meat or Plant-based Alternatives
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Ground beef|OTHER: Ground pork|OTHER: Tofu|OTHER: Beyond Meat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ozone Application in Periodontal Treatment
Status: RECRUITING
Conditions: Periodontitis
Interventions: DEVICE: Ozone therapy using a device (Ozone DTA Ozone Generator, Denta Tec Dental AS, Norway)|PROCEDURE: Non-surgical periodontal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Collagenase Chemonucleolysis vs Percutaneous Endoscopic Lumbar Discectomy (PELD) for Lumbar Disc Herniation
Status: RECRUITING
Conditions: Lumbar Disc Herniation
Interventions: PROCEDURE: Collagenase chemonucleolysis|PROCEDURE: Percutaneous endoscopic lumbar discectomy (PELD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Safety, Tolerability, Immunogenicity, and Bioactivity Study of DE-122 Injectable Solution for Refractory Exudative Age-related Macular Degeneration
Status: COMPLETED
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: 0.5 mg of DE-122|DRUG: 1.0 mg of DE-122|DRUG: 2.0 mg of DE-122|DRUG: 4.0 mg of DE-122
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Active Management of the Third Stage of Labour: Uterine Tonus Assessment by Midwife vs. Patient Self-administration
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: BEHAVIORAL: Uterine Tonus Assessment by Midwife|BEHAVIORAL: Patient self-assessment of uterine tonus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cediranib, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma
Status: COMPLETED
Conditions: Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma
Interventions: DRUG: Cediranib Maleate|PROCEDURE: Diffusion Tensor Imaging|PROCEDURE: Diffusion Weighted Imaging|PROCEDURE: Dynamic Contrast-Enhanced Magnetic Resonance Imaging|RADIATION: Fludeoxyglucose F-18|RADIATION: Intensity-Modulated Radiation Therapy|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Perfusion Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inpatient Rehabilitation and Post-Discharge Outcomes With High Intensity Gait Training (HIGT) of Patients With Stroke
Status: TERMINATED
Conditions: Cerebral Vascular Accident
Interventions: OTHER: High Intensity Gait Training|OTHER: Conventional Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypoallergenicity of a Hydrolyzed Protein Infant Formula
Status: SUSPENDED
Conditions: Cow's Milk Allergy
Interventions: OTHER: Hydrolyzed protein infant formula|OTHER: commercially available hypoallergenic infant formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older Homozygous for the F508del-CFTR Mutation
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DRUG: Ivacaftor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Hazelnut Flour on Blood Glucose
Status: COMPLETED
Conditions: Obesity|Celiac Disease|Blood Glucose|Flour Sensitivity
Interventions: DIETARY_SUPPLEMENT: Consumption of Cornbread with Hazelnut Bread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prolongation of Contact Lens Comfortable Wear Duration by CLM2 Topical Gel
Status: COMPLETED
Conditions: Contact Lens Discomfort|Contact Lens-induced Corneal Disorder|Contact Lens Acute Red Eye|Contact Lens-induced Corneal Fluorescein Staining
Interventions: DRUG: CLM2 topical gel|DRUG: Placebo topical gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Internet-based Self-help Cognitive Behavioural Therapy in Reducing Insomnia Among Adult Population
Status: COMPLETED
Conditions: Insomnia
Interventions: BEHAVIORAL: Internet-based self-help cognitive behavioural therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-angiogenetic Therapy With Radiotherapy for Pediatric Neuroblastoma
Status: UNKNOWN
Conditions: Neuroblastoma
Interventions: DRUG: Endostar|RADIATION: 21.6Gy/12Fx to the tumor bed and 36Gy/20Fx to the tumor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robot-assisted D2 Distal Gastrectomy Following Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancers
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: PROCEDURE: Robot-assisted D2 distal gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treosulfan-based Versus Busulfan-based Conditioning in Paediatric Patients With Non-malignant Diseases
Status: COMPLETED
Conditions: Primary Immunodeficiencies|Inborn Errors of Metabolism|Haemoglobinopathies|Bone Marrow Failure Syndromes
Interventions: DRUG: Treosulfan|DRUG: Busilvex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation for Adolescent Depression: Efficacy, Predictive Biomarkers, and Mechanisms
Status: COMPLETED
Conditions: Treatment Resistant Depression
Interventions: DEVICE: Active Repetitive Transcranial Magnetic Stimulation (rTMS): intensity 80% MT|DEVICE: Device: Active Repetitive Transcranial Magnetic Stimulation (rTMS); Stimulation intesity: 100% of MT|DEVICE: Device: Active Repetitive Transcranial Magnetic Stimulation (rTMS); Stimulation intesity: 120% of MT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Tranexamic Acid on Postpartum Hemorrhage During and After Cesarean Delivery
Status: COMPLETED
Conditions: Hemorrhage
Interventions: DRUG: Tranexamic acid|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Chemotherapy Followed by Radiation Therapy in Treating Adults With Supratentorial Glioma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: lomustine|DRUG: procarbazine hydrochloride|DRUG: vincristine sulfate|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of FAUCS vs. Misgav Ladach
Status: UNKNOWN
Conditions: Pain, Postoperative|Ambulation Difficulty
Interventions: PROCEDURE: French Abulatory Cesrean Section|PROCEDURE: Misgav-Ladach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Needle-Free Injection of Lidocaine for Local Anesthesia Prior to Trigger Digit Injection
Status: COMPLETED
Conditions: Trigger Finger
Interventions: PROCEDURE: Triamcinolone (20 g) and 2% Lidocaine injection over the A1 pulley|DRUG: 2% Lidocaine|DRUG: Triamcinolone (20 g)|PROCEDURE: J-tip lidocaine administration|PROCEDURE: Triamcinolone (20 g) Injection over the A1 pulley.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: MSOT in Pompe Disease
Status: UNKNOWN
Conditions: Pompe Disease|Pompe Disease (Late-onset)|Pompe's Disease Juvenile Onset|Pompe Disease Infantile-Onset
Interventions: DEVICE: Multispectral Optoacoustic Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Efficacy and Safety of Venglustat in Adult and Pediatric Patients With Gaucher Disease Type 3
Status: RECRUITING
Conditions: Gaucher's Disease Type III
Interventions: DRUG: Venglustat|DRUG: imiglucerase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of DHA on Periodontitis
Status: COMPLETED
Conditions: Periodontitis|Gingivitis|Inflammation
Interventions: DRUG: Aspirin|DRUG: Docosahexaenoic acid|DRUG: Placebo (for Docosahexaenoic acid)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inactivated Influenza Vaccine Effectiveness in Tropical Africa
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: seasonal trivalent inactivated influenza vaccine|BIOLOGICAL: inactivated polio vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: RC48 Plus AK105 and Cisplatin in Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Advanced Gastric Carcinoma|HER2-positive Gastric Cancer
Interventions: DRUG: RC48+AK105+cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parasite Clearance and Protection From Infection (PCPI) in Cameroon
Status: RECRUITING
Conditions: Malaria
Interventions: DRUG: SP (Macleods Pharmaceuticals Ltd)|DRUG: SPAQ (Guilin Pharmaceuticals)|DRUG: AS (Guilin Pharmaceuticals)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Pharmacokinetics/Pharmacodynamics of GK Activator (2) in Type 2 Diabetes Patients With Hepatic Impairment.
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: GK Activator (2)|DRUG: Ethanol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient Dimensions as Predictors of Varied Treatment Responses and Outcomes in Patients With Major Depression
Status: COMPLETED
Conditions: Depression|Major Depressive Disorder
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Interpersonal Therapy|DRUG: Antidepressant medication (sertraline ,paroxetineor or venlafaxine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of 68Ga-FAPI-04 PET/CT as a Problem Solving Imaging Modality in Various Malignancies
Status: UNKNOWN
Conditions: Different Types of Cancer
Interventions: RADIATION: 68Ga-FAPI-04 PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treatment of Unresectable Colorectal Metastases by Radiofrequency Ablation Combined or Not With Resection, With or Without Neoadjuvant Chemotherapy.
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DEVICE: Ablathermy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)
Status: RECRUITING
Conditions: Alzheimer's Disease|Prodromal Alzheimer's Disease|Amyloid Plaque|Beta-Amyloid|Alzheimer's Disease in Down Syndrome
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: ACI-24.060 at Dose A|BIOLOGICAL: ACI-24.060 at Dose B|BIOLOGICAL: ACI-24.060 at Dose C|BIOLOGICAL: ACI-24.060 at Dose D|BIOLOGICAL: Placebo|BIOLOGICAL: ACI-24.060 at Dose X|BIOLOGICAL: ACI-24.060 at Dose Y
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics and Pharmacodynamics of DSP-8658 in Patients With Type 2 Diabetes Mellitus and Healthy Adults
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: DSP-8658|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Interaction Between Ibuprofen and Acetaminophen, Tablets Administered Individually or in Combination
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: A1: Ibuprofen/Acetaminophen Fixed dose combination (Laboratorios Silanes S.A. de C.V.)|DRUG: A2: Ibuprofen (Motrin®, Pfizer S.A. de C.V.)|DRUG: A3: Acetaminophen (Tylenol caplets®, from Janssen-Cilag, S.A. de C.V.)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Glucovance to Insulin for Diabetes During Pregnancy
Status: UNKNOWN
Conditions: Gestational Diabetes|Type 2 Diabetes|Pregnancy
Interventions: DRUG: Insulin versus glucovance (glyburide/metformin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Proactive Infliximab Optimization Using a Pharmacokinetic Dashboard Versus Standard of Care in Patients With Inflammatory Bowel Disease: The OPTIMIZE Trial
Status: ENROLLING_BY_INVITATION
Conditions: Crohn Disease|Ulcerative Colitis|Inflammatory Bowel Diseases
Interventions: DRUG: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan
Status: RECRUITING
Conditions: Type2 Diabetes|Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: Empagliflozin 25 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: S3 Root Pulsed Radiofrequency Added to Superior Hypogstric Plexus Block
Status: UNKNOWN
Conditions: Pain Cancer|Pain, Chronic
Interventions: PROCEDURE: superior hypogastric plexus block|PROCEDURE: pulsed radiofrequency at S3 root plus superior hypogastric plexus block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Niraparib Plus Aromatase Inhibitors for Luminal-like(HER2-,ER+) and gBRCA or HDR+ Metastatic Breast Cancer (LUZERN)
Status: COMPLETED
Conditions: Breast Cancer|Breast Cancer Metastatic
Interventions: DRUG: Niraparib|DRUG: Aromatase Inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BIBW 2992 (Afatinib) With or Without Daily Temozolomide in the Treatment of Patients With Recurrent Malignant Glioma
Status: COMPLETED
Conditions: Glioma
Interventions: DRUG: BIBW 2992|DRUG: TMZ|DRUG: BIBW 2992 plus TMZ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Acarbose and Mixture of Pioglitazone and Metformin in Patients With Type 2 Diabetes
Status: RECRUITING
Conditions: Type 2 Diabetes|Blood Glucose Fluctuation
Interventions: DRUG: Metformin plus pioglitazone|DRUG: Acarbose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photoacoustic Imaging in Detecting Ovarian or Fallopian Tube Cancer
Status: WITHDRAWN
Conditions: Fallopian Tube Carcinoma|Ovarian Carcinoma
Interventions: PROCEDURE: Photoacoustic Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Immunogenicity, Reactogenicity of Shingrix in SLE
Status: RECRUITING
Conditions: Zoster|Systemic Lupus Erythematosus|Vaccine Reaction
Interventions: DRUG: Shingrix|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of FODMAPs on Small Bowel Water Content: an MRI Study
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Glucose|DIETARY_SUPPLEMENT: Fructose|DIETARY_SUPPLEMENT: Fructan|DIETARY_SUPPLEMENT: Fructose and glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Human Milk Oligosaccharides and Galacto-oligosaccharides on Iron Absorption in Kenyan Infants
Status: COMPLETED
Conditions: Anemia, Iron-deficiency
Interventions: DIETARY_SUPPLEMENT: ferrous fumarate|DIETARY_SUPPLEMENT: ferrous fumarate + GOS|DIETARY_SUPPLEMENT: ferrous fumarate + HMOs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Evaluation of a Unified Transdiagnostic Treatment for Anxiety Disorders
Status: COMPLETED
Conditions: Anxiety Disorders|Mood Disorders
Interventions: BEHAVIORAL: Single Diagnosis Treatment Protocol|BEHAVIORAL: Unified Protocol (UP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Cognitive Remediation
Status: COMPLETED
Conditions: Schizophrenia|Bipolar Disorder With Psychosis
Interventions: BEHAVIORAL: Cognitive Remediation|BEHAVIORAL: Sham Cognitive Remediation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Percutaneous Vertebroplasty for Painful Acute Osteoporotic Spine Fractures
Status: UNKNOWN
Conditions: Acute Osteoporotic Spinal Fractures
Interventions: PROCEDURE: Percutaneous vertebroplasty|OTHER: Conservative therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Matcha Tea Versus Green Tea on Salivary pH and Flow Rate in High Caries Risk Patients
Status: COMPLETED
Conditions: Salivary pH
Interventions: PROCEDURE: Matcha Tea|PROCEDURE: Green Tea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: RIPC on Activity, Fatigue and Gait in MS
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: OTHER: Ischaemic Preconditioning|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Chia on Overweight/Obese Women
Status: UNKNOWN
Conditions: Obesity|Eating Behavior|Mood|Glucose|Dietary Modification
Interventions: DIETARY_SUPPLEMENT: Chia Seeds- Salvia Hispanica
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT Evaluating Intranasal Fentanyl in the Pain Management of Children With Headaches
Status: TERMINATED
Conditions: Headaches
Interventions: DRUG: Fentanyl|OTHER: Salinex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of 4 Months of Exercise Changes of Heart Health-related Epigenetic Markers in Healthy, Sedentary Individuals
Status: COMPLETED
Conditions: Sedentary Behavior
Interventions: OTHER: supervised exercise training|OTHER: home-based exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy/Safety of HCP1306 Tablet Versus HGP0816 Tablet in Patients With Primary Hypercholesterolemia
Status: COMPLETED
Conditions: Primary Hypercholesterolemia
Interventions: DRUG: HGP0816 5mg|DRUG: HGP0816 10mg|DRUG: HGP0816 20mg|DRUG: HCP1306 5/10mg|DRUG: HCP1306 10/10mg|DRUG: HCP1306 20/10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability Study to Investigate a Potential Interaction Between DTG DT and F/TAF TOS.
Status: COMPLETED
Conditions: Hiv
Interventions: DRUG: DTG DT (6 x 5 mg)|DRUG: F/TAF TOS (3 x 60/7.5 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Combination of Cardonizumab Injection and TKI Second Line Therapy for Advanced Hepatocellular Cancer
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: TKI+Cardunilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Basic and Social Cognition in Veterans With Schizophrenia
Status: COMPLETED
Conditions: Schizoaffective Disorder|Schizophrenia
Interventions: BEHAVIORAL: Cognitive remediation|BEHAVIORAL: Social Cognitive skills training|BEHAVIORAL: hybrid intervention|BEHAVIORAL: skills training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of EMST Systemic Inflammation and Oxidative Stress in Patients With Moderate OSAS
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Oxidative Stress|Respiratory Muscle Training
Interventions: OTHER: Expiratory muscle trainig
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Omalizumab in Chronic Spontaneous Urticaria Patients Non Responding to Initial Standard antihistaminE Treatment
Status: COMPLETED
Conditions: CHRONIC SPONTANEOUS URTICARIA
Interventions: DRUG: OMALIZUMAB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PolyArginine Treated vEiN grafTs (PATENT)
Status: TERMINATED
Conditions: Saphenous Vein Graft Disease
Interventions: DRUG: Nona-L-arginine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Envi™-SR Randomized Controlled Trial for Endovascular Treatment of Ischemic Stroke
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DEVICE: Mechanical Thrombectomy using the Envi™-SR Thrombectomy device|DEVICE: Mechanical Thrombectomy using the Solitaire or Trevo Revascularization Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Arsenic Trioxide in Recurrent and Metastatic Ovarian Cancer and Endometrial Cancer With P53 Mutation
Status: UNKNOWN
Conditions: Ovarian Cancer|Endometrial Cancer
Interventions: DRUG: Arsenic trioxide for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gene Therapy Using Anti-CEA Cells to Treat Metastatic Cancer
Status: TERMINATED
Conditions: Metastatic Cancer
Interventions: BIOLOGICAL: PG13-CEA_TCR (Anti-CEA TCR PBL)|DRUG: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of the P.L.A.Y. (Play and Language for Autistic Youngsters) Project Intervention for Autism
Status: COMPLETED
Conditions: Autism|Autism Spectrum Disorder
Interventions: BEHAVIORAL: PLAY Project Intervention for Autism|BEHAVIORAL: Special education pre-school
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Reported Outcomes in Friedreich's Ataxia Patients After Withdrawal From Treatment With Idebenone (PROTI)
Status: COMPLETED
Conditions: Friedreich's Ataxia
Interventions: DRUG: Idebenone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Group Therapy for Caregivers of Alzheimer's Disease Patients in Spanish Elderly Persons Centres
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: BEHAVIORAL: Psychotherapy groups|BEHAVIORAL: Self-help groups
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Steady State Cobicistat and Darunavir/Cobicistat on the Pharmacokinetics and Pharmacodynamics of Oral Anticoagulants (Rivaroxaban, Apixaban) in Health Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Cobicistat|DRUG: Darunavir/Cobicistat|DRUG: Rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Percutaneous Treatment by Cryoablation of Unifocal Invasive Breast Carcinoma in Menopausal Women With Indication of Lumpectomy
Status: COMPLETED
Conditions: Carcinoma, Ductal, Breast|Menopausal
Interventions: DEVICE: Cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Universal Screening for Lynch Syndrome in Chinese Patients of Endometrial Cancer
Status: UNKNOWN
Conditions: Colorectal Neoplasms, Hereditary Nonpolyposis|Endometrial Neoplasms
Interventions: DIAGNOSTIC_TEST: immunohistochemical staining|DIAGNOSTIC_TEST: tests of microsatellite instability|DIAGNOSTIC_TEST: clinical criteria of Lynch syndromes|DIAGNOSTIC_TEST: sequencing for mismatch repair genes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of L-PRF as an Antibiotic Slow-release Biological Device in the Treatment of Moderate Periodontitis
Status: COMPLETED
Conditions: Periodontitis
Interventions: DRUG: Subgingival application of L-PRF loaded with metronidazole|OTHER: Subgingival application of L-PRF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Cardiovascular Risk in Primary Care: a Randomized Clinical Trial
Status: UNKNOWN
Conditions: Cardiovascular Diseases|Compliance, Medication|Physical Inactivity|Hypertension|Diabetes Mellitus|Lipid Disorder
Interventions: OTHER: Health App|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Benefits of a Cognitive Behavioral Therapy Intervention for Smoking Cessation Supported by Virtual Reality Smoking Cue Exposure
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: CBT smoking cessation|BEHAVIORAL: virtual reality based cue exposure|BEHAVIORAL: progressive muscle relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Videogame-based Tool for Job Search and Executive Function Improvement in Adults With ASD
Status: WITHDRAWN
Conditions: Autism Spectrum Disorder
Interventions: DEVICE: Use of Identifor assessment tool and Companion app|OTHER: Referral to employment agencies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Docetaxel and Prednisone in Treating Patients With Hormone-Refractory Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: docetaxel|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Magnetic Mini-Mover Procedure to Treat Pectus Excavatum
Status: COMPLETED
Conditions: Pectus Excavatum
Interventions: DEVICE: Magnetic Mini-Mover Procedure (3MP)|DEVICE: Magnatract (external magnet in a removable external brace)|PROCEDURE: 3MP (Magnetic Mini-Mover Procedure)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of PBI-200 in Subjects With NTRK-Fusion-Positive Solid Tumors
Status: TERMINATED
Conditions: Solid Tumor, Adult|Brain Tumor, Primary|Desmoplastic Small Round Cell Tumor
Interventions: DRUG: PBI-200
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficiency of XAL-EASE Device in Glaucoma and/or Ocular Hypertension (OHT) Patients, Treated With Xalatan or Xalacom
Status: UNKNOWN
Conditions: Glaucoma|Hypertension
Interventions: DEVICE: Xal-Ease
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE