pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A PhaseⅡ Study to Evaluate the Safety and Immunogenicity of COVID-19 Vaccine
Status: RECRUITING
Conditions: SARS-CoV-2 Infection
Interventions: BIOLOGICAL: COVID-19 mRNA Vaccine (ZSVG-02-O)|BIOLOGICAL: COVID-19 mRNA Vaccine (ZSVG-02-O)|BIOLOGICAL: COVID-19 Vaccine (Vero Cell) ,Inactivated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating the Safety & Efficacy of DVS-223 SR for Relief of Vasomotor Symptoms Associated With Menopause
Status: COMPLETED
Conditions: Vasomotor Symptoms
Interventions: DRUG: DVS-233 SR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Switching to Low Oxidant Content Cigarettes in Adult Smokers
Status: COMPLETED
Conditions: Nicotine|Oxidative Stress
Interventions: OTHER: Reduced ROS/RNS content products|OTHER: Typical to high (ROS/NOS) products
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Pomalidomide Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain Tumors
Status: COMPLETED
Conditions: Central Nervous System Neoplasms|Medulloblastoma
Interventions: DRUG: Pomalidomide|DRUG: Pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Treatments of Osteoporotic Compression Fracture Using Rigid Brace, Soft Brace, and no Brace
Status: COMPLETED
Conditions: Compression Fracture
Interventions: DEVICE: No brace treatment|DEVICE: Rigid brace|DEVICE: Soft brace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Innovative Models in the Rehabilitation of the Elderly With Parkinson's Disease Through Technological Innovation
Status: RECRUITING
Conditions: Parkinson Disease|Frail Elderly|Robotic Devices in Rehabilitation
Interventions: OTHER: control arm|OTHER: virtual reality games|OTHER: robotic treadmill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnesium Sulfate in Surgical Stress Attenuation Postoperative Sore Throat and Stress Response Induced Tracheal Intubation
Status: NOT_YET_RECRUITING
Conditions: Anesthesia Complication|Anesthesia Intubation Complication
Interventions: PROCEDURE: Magnesium sulfate vaporization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases|Adherence, Medication|Medication Adherence|Diabetes Mellitus|Hypertension|Hyperlipidemias|Coronary Artery Disease|Atrial Fibrillation
Interventions: BEHAVIORAL: Nudge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase 3 Safety and Efficacy Study of ART-123 in Subjects With Severe Sepsis and Coagulopathy
Status: COMPLETED
Conditions: Severe Sepsis|Coagulopathy
Interventions: DRUG: ART-123|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Dental Plaque and Gingival Index
Status: COMPLETED
Conditions: Dental Plaque
Interventions: DRUG: Sodium Monofluorophosphate|DRUG: Triclosan/Fluoride/Copolymer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Padres Efectivos (Parent Activation): Skills Latina Mothers Use to Get Healthcare for Their Children
Status: COMPLETED
Conditions: Mental Disorders
Interventions: BEHAVIORAL: activation curriculum|BEHAVIORAL: support group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Cysteine Hydrochloride for Erythropoietic Protoporphyria
Status: COMPLETED
Conditions: Erythropoietic Protoporphyria
Interventions: DRUG: cysteine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Detection of Small Esophageal Varices by PillCam ESO
Status: WITHDRAWN
Conditions: Esophageal Varices
Interventions: DEVICE: Capsule endoscopy (PillCam ESO)|PROCEDURE: EGD|DEVICE: Capsule endoscopy (PillCam ESO) with abdominal binder
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Study of BAT2506 With Simponi® in Participants With Active Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: BAT2506|DRUG: EU Simponi
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Innovations in Dementia Empowerment and Action
Status: COMPLETED
Conditions: Alzheimer Disease|Dementia|Mild Cognitive Impairment|Parkinson Disease Dementia|Lewy Body Dementia|Vascular Dementia
Interventions: BEHAVIORAL: Innovations in Dementia Empowerment and Action (IDEA)|BEHAVIORAL: Reducing Disabilities in Alzheimer's Disease (RDAD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Probiotic Bacteria to Infants With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: BEHAVIORAL: Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ُEfficacy of Insulin Versus Hyalase Hydro-dissection of Median Nerve in Rheumatoid Arthritis Patients
Status: UNKNOWN
Conditions: Treatment Resistant Carpal Tunnel in RA Patients
Interventions: DRUG: Hylase|DRUG: Insulin|OTHER: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of OmniWave Endovascular System to Treat Deep Vein Thrombosis
Status: UNKNOWN
Conditions: Deep Vein Thrombosis
Interventions: DEVICE: OmniWave Endovascular System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nebulized Salbutamol in Acute Renal Colic
Status: NOT_YET_RECRUITING
Conditions: Renal Colic
Interventions: DRUG: Salbutamol|OTHER: 0.9% Normal Saline|DRUG: Diclofenac Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lidocaine Patches in Elderly Patients With Traumatic Rib Fractures
Status: RECRUITING
Conditions: Rib Fractures
Interventions: OTHER: Placebo Patch|DRUG: 4% Lidocaine Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ozone Therapy in Patients With Carpal Tunnel Syndrome
Status: RECRUITING
Conditions: Carpal Tunnel Syndrome
Interventions: OTHER: range of motion exercises|DEVICE: Extracorporeal shock wave therapy|OTHER: ozone therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PROactive Evaluation of Function to Avoid CardioToxicity
Status: TERMINATED
Conditions: Cardiotoxicity|Breast Cancer|Lymphoma|Sarcoma|Leukemia|Myeloma|Lung Cancer
Interventions: DEVICE: MyoStrain®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Acalabrutinib in Chinese Adult Subjects With Relapsed or Refractory Mantle Cell Lymphoma, Chronic Lymphocytic Leukemia or Other B-cell Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Phase I: Relapsed or Refractory B-cell Malignancies|Phase II Cohort A: Relapsed or Refractory Mantle Cell Lymphoma|Phase II Cohort B: Relapsed or Refractory Chronic Lymphocytic Leukemia
Interventions: DRUG: Acalabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Emotion Regulation in Eating Disorders: How Can Art Therapy Contribute to Treatment Outcome?
Status: COMPLETED
Conditions: Eating Disorders|Anorexia Nervosa|Bulimia Nervosa|Binge-Eating Disorder
Interventions: OTHER: art therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of PET/CT Imaging Using INR101 Injection in Healthy Male Subjects and Patients With Suspected Prostate Cancer
Status: RECRUITING
Conditions: Healthy Male Subjects|Suspected Prostate Cancer
Interventions: DRUG: INR101|DRUG: INR101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Vouchers to Increase Uptake of Already Free Eye Care
Status: COMPLETED
Conditions: Glaucoma|Eye Diseases
Interventions: BEHAVIORAL: Voucher Without Value Information|BEHAVIORAL: Voucher With Value Information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Dietary Nitrate on Blood Pressure and Cardiovascular Disease Risk Factors
Status: UNKNOWN
Conditions: Hypertension|Blood Pressure, High
Interventions: OTHER: High-nitrate dehydrated vegetable powder|OTHER: Low-nitrate dehydrated vegetable powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Do Videos That Aim to Optimize Expectations Alter the Effectivess of PMR?
Status: COMPLETED
Conditions: Experimental Group 1 (Video Personal Expert)|Experimental Group 2 (Video Factual Expert)|Control Group
Interventions: BEHAVIORAL: Progressive Muscle Relaxation (PMR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Person-Centered Oncology Care and Choices (P-COCC): Piloting and Initial Randomized Testing of a Combined Values Narrative Interview and Video Education Advance Care Planning Program in Gastrointestinal Oncology Patients
Status: COMPLETED
Conditions: Advanced Gastrointestinal Cancer
Interventions: BEHAVIORAL: single pilot interview|BEHAVIORAL: goals-of-care (GOC) video|BEHAVIORAL: goals-of-care (GOC) video and narrative question|BEHAVIORAL: usual care|BEHAVIORAL: Part 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of Intravenous WCK 771
Status: COMPLETED
Conditions: Bioavailability
Interventions: DRUG: WCK 771 IV Infusion|OTHER: Placebo IV Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Integrated Supportive and Palliative Care for Older Adults in the ICU
Status: RECRUITING
Conditions: Critical Illness
Interventions: BEHAVIORAL: Early Integration of Specialty Palliative Care with Critical Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Promoting Adherence to Anti-Hypertensive Medications and Lifestyle Guidelines Through Mindfulness Practice
Status: COMPLETED
Conditions: Health Behavior Modification Using Mindfulness
Interventions: BEHAVIORAL: Mindful Awareness Program|BEHAVIORAL: Health Promotion Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Selonsertib in Combination With Prednisolone Versus Prednisolone Alone in Participants With Severe Alcoholic Hepatitis (AH)
Status: COMPLETED
Conditions: Alcoholic Hepatitis (AH)
Interventions: DRUG: Selonsertib|DRUG: Prednisolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells for Solid Tumors
Status: RECRUITING
Conditions: Liver Cell Carcinoma|Solid Tumor|Wilms Tumor|Malignant Rhabdoid Tumor|Yolk Sac Tumor|Rhabdomyosarcoma|Liposarcoma|Embryonal Sarcoma of the Liver
Interventions: GENETIC: CATCH T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome
Status: RECRUITING
Conditions: Short Bowel Syndrome|Infection, Bacterial
Interventions: DRUG: Amoxicillin|DRUG: Levofloxacin|DRUG: Ofloxacin|DRUG: Sulfamethoxazole trimethoprim
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Upper Extremity Rehabilitation Robot and Transcranial Direct Current Stimulation in Chronic Stroke
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: Robot and tDCS on-line|DEVICE: Robot and tDCS on-line after sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Isoflavones & Lycopene in Localized Prostate Ca:Prior to Radical Prostatectomy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: Lycopene|DIETARY_SUPPLEMENT: Multivitamin|DIETARY_SUPPLEMENT: Soy isoflavones
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Bioactive Giomer Material Versus Nanohybrid Resin Composite in Deep Marginal Elevation
Status: NOT_YET_RECRUITING
Conditions: Deep Caries|Dental Caries
Interventions: OTHER: Beautifil II LS|OTHER: Nanohybrid resin composite material
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Abemaciclib (LY2835219) in Women With HR+, HER2+ Locally Advanced or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Hormone Receptor Positive Breast Cancer|HER-2 Positive Breast Cancer
Interventions: DRUG: Abemaciclib|DRUG: Trastuzumab|DRUG: Fulvestrant|DRUG: Standard of Care Single Agent Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 1-Week Dispensing Evaluation of Kalifilcon A Daily Disposable Multifocal Compared to Ultra for Presbyopia
Status: COMPLETED
Conditions: Presbyopia
Interventions: DEVICE: kalifilcon A Daily Disposable Multifocal|DEVICE: samfilcon A for Presbyopia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treating Patients With Renal Impairment and Altered Glucose MetAbolism With TherapeutIc Carbohydrate Restriction and Sglt2-Inhibiton - a Pilot Study
Status: RECRUITING
Conditions: Chronic Kidney Diseases|Diabetes Mellitus|PreDiabetes|Overweight and Obesity
Interventions: BEHAVIORAL: Therapeutic carbohydrate restriction combined with an SGLT-2-Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study of Mixed Bacteria Vaccine (MBV) in Patients With Tumors Expressing NY-ESO-1 Antigen
Status: COMPLETED
Conditions: Melanoma|Sarcoma|Gastrointestinal Stromal Tumor (GIST)|Head and Neck Cancer|Transitional Cell Carcinoma|Prostate Cancer|Ovarian Carcinoma|Esophageal Cancer|Breast Cancer
Interventions: BIOLOGICAL: Mixed bacterial vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kinesio Taping Versus Oromotor Training on Drooling in Children With Spastic Cerebral Palsy
Status: COMPLETED
Conditions: Drooling|Kinesiotape|Cerebral Palsy
Interventions: OTHER: KINESIOTAPE|OTHER: oromotor training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study on Dose Optimization of Fruquintinib in Elderly mCRC Patients Refractory to Standard Treatment（DOFEMCRC）
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Fruquintinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Accuracy, Safety and Robustness of a Single-input-single-output (SISO) Model-based Predictive Closed-loop System to Guide Patient-individualized ICU Sedation
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: SISO model-based predictive closed-loop system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of XB010 in Subjects With Solid Tumors
Status: RECRUITING
Conditions: Locally Advanced or Metastatic Solid Tumors
Interventions: DRUG: XB010|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Serratus Posterior Superior Intercostal Plane Block and Pectoralis Nerve Block in Coronary Artery Surgery
Status: COMPLETED
Conditions: Postoperative;Pain Management
Interventions: PROCEDURE: Group serratus posterior superior intercostal plane block (SPSIPB)|PROCEDURE: Group pectoralis nerve block (PECS-II)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cognoa Autism Spectrum Disorder (ASD) Digital Therapeutic Engagement and Usability Study
Status: TERMINATED
Conditions: Autism Spectrum Disorder
Interventions: DEVICE: Usability assessment of Cognoa ASD Therapeutic Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Low Dose Aspirin on Birthweight in Twins: The GAP Trial.
Status: COMPLETED
Conditions: Small for Gestational Age|Infant, Very Low Birth Weight|Fetal Growth Retardation|Preeclampsia|Premature Birth
Interventions: DRUG: Acetylsalicylic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Local Thrombolytics Before Thrombectomy in STEMI
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: Urokinase|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SPOG 2015 FN Definition. A Multi-center Non-inferiority Trial on Safety of a High Versus Low Temperature Limit Defining Fever in Pediatric Patients With Cancer at Risk for Fever in Chemotherapy-induced Neutropenia
Status: COMPLETED
Conditions: Cancer|Pediatrics|Fever|Neutropenia|Fever in Neutropenia
Interventions: OTHER: 39.0°C temperature limit defining fever|OTHER: 38.5°C temperature limit defining fever
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomized Trial of Transcatheter Valve-in-Valve vs Redo Surgery for Bioprosthetic Mitral Dysfunction
Status: RECRUITING
Conditions: Mitral Prosthetic Valve Stenosis and Regurgitation
Interventions: PROCEDURE: Transcatheter Valve-in-Valve Intervention|PROCEDURE: Redo Mitral valve surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OPTImal Management of Antithrombotic Agents: OPTIMA-5
Status: UNKNOWN
Conditions: Acute Coronary Syndrome (ACS)
Interventions: DRUG: Switch ticagrelor to clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enalapril Maleate on Arterial Stiffness in Rheumatoid Arthritis.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Enalapril Maleate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate How Safe Pozelimab + Cemdisiran Combination Therapy is and How Well it Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have Not Recently Received or Have Not Received Complement Inhibitor Treatment
Status: RECRUITING
Conditions: Paroxysmal Nocturnal Hemoglobinuria
Interventions: DRUG: Ravulizumab|DRUG: Pozelimab|DRUG: Cemdisiran|DRUG: Eculizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Knee Osteoarthritis With PAAG-OA
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: PAAG-OA|DEVICE: Synvisc-One
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PGL4001 Versus GnRH-agonist in Uterine Myomas
Status: COMPLETED
Conditions: Uterine Myomas
Interventions: DRUG: PGL4001|DRUG: leuprorelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical, Genetic and Environmental Determinants of Prostate Cancer Progression.
Status: RECRUITING
Conditions: Prostatic Neoplasm|Adenocarcinoma|Neoplasm Recurrence|Neoplasm Metastasis
Interventions: OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Enoxaparin Versus Placebo for Venous Thromboembolism Prevention in Low Risk Cancer Patients After Surgical Procedures: a Randomized, Double Blind, Placebo Controlled Clinical Trial Pilot Study
Status: WITHDRAWN
Conditions: Venous Thromboembolism|Bleeding as Surgical Complication (Treatment)|Deep Venous Thrombosis|Pulmonary Embolism
Interventions: DRUG: Receipt of enoxaparin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Colchicine in HFpEF
Status: TERMINATED
Conditions: Heart Failure|Inflammation|Colchicine
Interventions: DRUG: Colchicine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Lot to Lot Consistency of SIIPL Meningococcal ACYWX Conjugate Vaccine and to Compare Its Safety and Immunogenicity With That of Licensed Meningococcal ACWY Vaccine Menactra® in Healthy Individuals 18-85 Years of Age
Status: COMPLETED
Conditions: Vaccine for Meningococcal Disease
Interventions: BIOLOGICAL: NmCV-5|BIOLOGICAL: Menactra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: 4-Hydroxytamoxifen or Tamoxifen Citrate in Treating Women With Newly Diagnosed Ductal Breast Carcinoma in Situ
Status: COMPLETED
Conditions: Ductal Breast Carcinoma in Situ|Estrogen Receptor-positive Breast Cancer
Interventions: DRUG: oral placebo|DRUG: afimoxifene|DRUG: tamoxifen citrate|DRUG: placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Biomechanical Correction in Medial Tibiofemoral Joint Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis Knee
Interventions: OTHER: Biomechanical corrections|OTHER: Conventional Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Susceptibility of Motor-Evoked Potentials to Varying Targeted Blood Levels of Dexmedetomidine
Status: COMPLETED
Conditions: Scoliosis
Interventions: DRUG: low dexmedetomidine, low propofol|DRUG: high dexmedetomidine, low propofol|DRUG: Dexmedetomidine|DRUG: Dexmedetomidin|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy of Digital Problem Solving Application in Reduction of Anxiety, Depression and Substance Use Disorder Symptoms
Status: NOT_YET_RECRUITING
Conditions: Anxiety|Depressive Symptoms|Substance Use Disorders
Interventions: COMBINATION_PRODUCT: DSPT - Digital Support for Problem-solving Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validity Of Ultrasound As Regards Correlation To Cormack-Lehane Grading In Obese Patients
Status: UNKNOWN
Conditions: Difficult Airway Intubation
Interventions: DEVICE: Assessing validity of ultrasound as regards correlation to Cormack-Lehane grading in obese patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Pulse Chips and Commercial Snacks on Food Intake, Appetite and Blood Glucose in Healthy Young Adults
Status: UNKNOWN
Conditions: Obesity|Diabetes
Interventions: DIETARY_SUPPLEMENT: Corn Chips + Onion Dip|DIETARY_SUPPLEMENT: Yellow pea chip + hummus|DIETARY_SUPPLEMENT: Pinto bean chip + hummus|DIETARY_SUPPLEMENT: Pinto bean chip + onion dip|DIETARY_SUPPLEMENT: Yellow pea chip + onion dip|DIETARY_SUPPLEMENT: Corn chips + hummus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tailored Support for Type 2 Diabetes Patients With an Acute Coronary Event After Discharge From Hospital
Status: COMPLETED
Conditions: Type 2 Diabetes|Acute Coronary Event
Interventions: OTHER: Home visits|OTHER: Consultation by telephone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Prospective, Randomized, Double-blind, Parallel, Active-controlled Clinical Study of Silicone Hydrogel Monthly Soft Contact Lens for the Safety and Effectiveness in Visual Correction.
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Soft Contact Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Social Cognition for Adults With ASD by the Serious Game JeStiMulE Versus Controls
Status: COMPLETED
Conditions: Autistic Disorder
Interventions: OTHER: serious game JeStiMulE|OTHER: control video game
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of Infigratinib in Combination With Tamoxifen in Hormone Receptor Positive, HER2 Negative, FGFR Altered Advanced Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer|HER2-negative Breast Cancer|ER Positive Breast Cancer|PR-Positive Breast Cancer
Interventions: DRUG: Infigratinib|DRUG: Tamoxifen|DRUG: Omnipaque 350|DRUG: Iopamidol|DIAGNOSTIC_TEST: Computed tomography (CT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Coronary RevascularizatiOn VERsus Coronary-Artery Bypass Grafting for Multivessel Disease in Patients With Left Ventricular Dysfunction (PROVERB)
Status: RECRUITING
Conditions: Heart Failure|Revascularization
Interventions: PROCEDURE: Percutaneous coronary intervention|PROCEDURE: Coronary artery bypass grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Bone-patellar Tendon-bone Transplantation
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Rupture
Interventions: PROCEDURE: BPTB double-bundle allograft|PROCEDURE: BPTB single-bundle allograft group|PROCEDURE: BPTB single-bundle autograft group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A 12-week Randomized Study to Evaluate Oral Istradefylline in Subjects With Moderate to Severe Parkinson's Disease
Status: COMPLETED
Conditions: Idiopathic Parkinson's Disease
Interventions: DRUG: Istradefylline 40 mg|DRUG: Istradefylline 20 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Infusion of Donor Lymphocytes Depleted of CD25+ Regulatory T-cells in Patients With Relapsed Hematologic Malignancies
Status: COMPLETED
Conditions: Hematologic Malignancies
Interventions: DEVICE: CliniMACS CD25 Reagent Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study on Pseudoephedrine HCl 120 mg ER Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 120 mg Pseudoephedrine hydrochloride extended release tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Effectiveness and Safety of Tigecycline for Therapy of Infections Caused by Multi-Drug Resistant Acinetobacter Baumannii
Status: UNKNOWN
Conditions: Antibiotic Resistant Infection
Interventions: DRUG: Tigecycline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetic Field Therapy Versus Transcutaneous Electrical Nerve-stimulation in Knee Osteoarthritis
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DEVICE: comparing efficacy of TENS and PEMF in knee osteoarthritis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of a Ficus Carica on Improvement in Bowl Movements in Female Volunteer With Functional Constipation
Status: COMPLETED
Conditions: Functional Constipation
Interventions: DIETARY_SUPPLEMENT: Ficus carica (Fig paste)|DIETARY_SUPPLEMENT: Placebo (Placebo paste)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Initial Combination With Pioglitazone Study (0431-064)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: sitagliptin 100 mg q.d./pioglitazone 30 mg q.d|DRUG: Comparator: placebo to match sitagliptin 100 mg q.d./pioglitazone 30 mg q.d.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of and Treatment Applied to Food Addiction in a Rural Healthy Behaviors Clinic
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Intervention Control|BEHAVIORAL: Counselling|DRUG: Contrave|DRUG: Contrave and Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Standard and Minidose Spinal Anesthesia for Cesarean Section Operation Using Marcaine Spinal 0.5% Heavy
Status: UNKNOWN
Conditions: Cesarean Section|Anesthesia, Spinal|Local Anaesthetics Causing Adverse Effects in Therapeutic Use
Interventions: DRUG: Bupivacaine and Fentanyl|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerance of Local Heat Application in the Paralyzed Area of Patients With Complete Paraplegia
Status: COMPLETED
Conditions: Perfusion; Complications
Interventions: DEVICE: HydroSun|DEVICE: Hilotherm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Resiquimod for the Treatment of Early Stage Cutaneous T Cell Lymphoma (CTCL)
Status: COMPLETED
Conditions: Cutaneous T Cell Lymphoma
Interventions: DRUG: Topical resiquimod 0.06%|DRUG: topical resiquimod 0.03%
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Protein and Calcium on Weight Change and Blood Lipid Profile
Status: COMPLETED
Conditions: Prevention of Obesity
Interventions: DIETARY_SUPPLEMENT: Whey protein|DIETARY_SUPPLEMENT: Whey protein enriched with calcium|DIETARY_SUPPLEMENT: Soy protein|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Conventional or High Definition tDCS to Enhance Implicit Motor Sequence Learning in Healthy Young Adults?
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: 1x1 Low Intensity Transcranial Direct Current Stimulation (tDCS)|DEVICE: 4x1 Multichannel Stimulation Adapter for High Definition Transcranial Direct Current Stimulation (HD tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Omics-based Predictors of NAFLD/Potential NASH
Status: UNKNOWN
Conditions: Non-Alcoholic Fatty Liver Disease|Non Alcoholic Steatohepatitis
Interventions: DIAGNOSTIC_TEST: Genomics (DNA Extraction)|DIAGNOSTIC_TEST: Epi-genomics|DIAGNOSTIC_TEST: Proteomics (Glycoproteomics)|DIAGNOSTIC_TEST: Salivary Metabolomics|BEHAVIORAL: Individualized counselling for behavioural modification
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Defactinib Combined With Pembrolizumab and Gemcitabine in Patients With Advanced Cancer
Status: COMPLETED
Conditions: Advanced Solid Tumors|Solid Tumors|Pancreatic Cancer
Interventions: BIOLOGICAL: Defactinib|BIOLOGICAL: Pembrolizumab|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study Comparing Methylprednisolone Suspension To Methylprednisolone Tablets
Status: WITHDRAWN
Conditions: Therapeutic Equivalency
Interventions: DRUG: methylprednisolone|DRUG: methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison Between Pregabalin and Magnesium Sulfate in Hypotensive Anaesthesia
Status: UNKNOWN
Conditions: Functional Endoscopic Sinus Surgery
Interventions: DRUG: Pregabalin 150mg|DRUG: Magnesium Sulfate|DRUG: Nitroglycerin|OTHER: surgeon satisfaction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Efficacy CompariSon of Pre-stenting Atherectomy Versus Scoring ballooN for calcifieD Coronary Lesions Coronary Lesions
Status: UNKNOWN
Conditions: Atherosclerosis|Coronary Artery Disease
Interventions: DEVICE: Rotational atherectomy|DEVICE: Orbital atherectomy|DEVICE: Scoring balloon system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Why Does Aspirin Fail in Secondary Cerebrovascular Prevention? A Multicenter Prospective Case - Control Study
Status: UNKNOWN
Conditions: Cerebrovascular Disease
Interventions: DIAGNOSTIC_TEST: TXB2 assay of serum , and 11-dehydro-TXB2 assay of urine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of PC786 to Evaluate the Antiviral Activity, Safety and Pharmacokinetics of Multiple Doses in an RSV Challenge Study
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: DRUG: PC786|DRUG: Placebo/vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: FDOPA-PET/MRI for the Pre-operative Evaluation of Gliomas
Status: TERMINATED
Conditions: Glioma|Malignant Glioma
Interventions: DRUG: 6-[F-18]-Fluoro-L-3,4,-dihydroxyphenylalanine|DEVICE: PET/MRI|PROCEDURE: Surgical resection (standard of care)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Fludarabine, Cyclophosphamide, and Rituximab in Treating Patients With Prolymphocytic Leukemia
Status: TERMINATED
Conditions: Prolymphocytic Leukemia
Interventions: BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: fludarabine phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Specific Immunotherapy With CLUSTOID Grass Pollen
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: BIOLOGICAL: Subcutaneous injections with highly polymerized allergen extract|BIOLOGICAL: Subcutaneous injection with placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Expanded Access Program to Provide Treatment With Pitolisant to Adult Patients in the U.S. With Excessive Daytime Sleepiness Associated With Narcolepsy With or Without Cataplexy
Status: NO_LONGER_AVAILABLE
Conditions: Narcolepsy Without Cataplexy|Narcolepsy With Cataplexy
Interventions: DRUG: Pitolisant
Study Type: EXPANDED_ACCESS
Clinical trial: Valor II: The Valiant Thoracic Stent Graft System Clinical Study
Status: COMPLETED
Conditions: Thoracic Aortic Aneurysm
Interventions: DEVICE: Valiant Thoracic Stent Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise Device in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Total Knee Arthroplasty|Total Knee Replacement
Interventions: DEVICE: Easy-Flex|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Preoperative Anxiety and Depression on Short-term Postoperative Recovery in Early Gastric Cancer
Status: WITHDRAWN
Conditions: Postoperative Complications|Anxiety|Depression|Coping Behavior
Interventions: DIAGNOSTIC_TEST: Quality of Recovery -15
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: NINDS CRC Chronic Migraine Treatment Trial
Status: COMPLETED
Conditions: Chronic Migraine
Interventions: DRUG: propranolol LA|DRUG: topiramate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Adding Venetoclax to the High-dose Chemotherapy Regimen Prior to Mismatche Allogeneic Stem Cell Transplant
Status: WITHDRAWN
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: Venetoclax|DRUG: Decitabine|DRUG: Fludarabine|DRUG: Busulfan|RADIATION: Total Body Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Acceptance and Commitment Therapy (ACT) in Group in Fibromyalgia
Status: UNKNOWN
Conditions: Fibromyalgia
Interventions: BEHAVIORAL: ACT in group|BEHAVIORAL: Improved treatment as usual by General Practitioners
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Participatory Patient Care Planning in Primary Care
Status: UNKNOWN
Conditions: Hypertension|Ischemic Heart Disease|Diabetes Mellitus
Interventions: BEHAVIORAL: Participatory patient care planning|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of TLK199 Tablets in Myelodysplastic Syndrome (MDS)
Status: COMPLETED
Conditions: Myelodysplastic Syndrome (MDS)
Interventions: DRUG: Ezatiostat Hydrochlorine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pregnancy Monitoring Using Mobile Application
Status: NOT_YET_RECRUITING
Conditions: Maternal and Child Health
Interventions: DEVICE: mobile application REST (Risk identification, Evaluation counseling, Systematic monitoring, Troubleshooting)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cicletanine in Hypertension With Diabetes: Added Magnesium Preserves Potassium and Sodium
Status: UNKNOWN
Conditions: Arterial Hypertension|Diabetes|Hypokalemia|Hyponatremia
Interventions: DRUG: Cicletanine + magnesium|DRUG: Cicletanine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study to Determine Pembrolizumab as Frontline Treatment of Patients With Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Hodgkin Lymphoma
Interventions: DRUG: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Examining the Effects of CXB722 in Neuroendocrine Stress Response in Healthy Males
Status: COMPLETED
Conditions: Stress|Anxiety
Interventions: DRUG: CXB722|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-Operative Urinary Retention (POUR) in Thoracic Surgery Patients Receiving Prophylactic Tamsulosin
Status: RECRUITING
Conditions: Thoracic Diseases|Urinary Retention
Interventions: DRUG: Tamsulosin Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pragmatic Trial of An Adaptive eHealth HIV Prevention Program for Diverse Adolescent MSM
Status: COMPLETED
Conditions: Hiv|Adolescent Behavior|Sex, Safe
Interventions: BEHAVIORAL: Queer Sex Ed|BEHAVIORAL: Keep It Up|BEHAVIORAL: Keep It Up-Control|BEHAVIORAL: Young Men's Health Project
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Using a Targeted Cancer Vaccine (Galinpepimut-S) With Immunotherapy (Nivolumab) in Mesothelioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Mesothelioma|Pleural Mesothelioma|Wilms Tumor
Interventions: BIOLOGICAL: Galinpepimut-S|DRUG: Nivolumab|BIOLOGICAL: Sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Xenon Against Postoperative Oxygen Impairment
Status: UNKNOWN
Conditions: Acute Lung Injury
Interventions: OTHER: oxygen|DRUG: Xenon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Olopatadine Nasal Spray
Status: COMPLETED
Conditions: Perennial Allergic Rhinitis
Interventions: DRUG: Olopatadine 0.6% nasal spray|DRUG: Placebo Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DOLPHIN-VIVO: Diagnosis Of LymPHoma IN Vivo (Ex Vivo Phase)
Status: COMPLETED
Conditions: Lymphoma|Head and Neck Cancer
Interventions: DIAGNOSTIC_TEST: spectroscopic measurement|DIAGNOSTIC_TEST: FNA biopsy|DIAGNOSTIC_TEST: histopathology and cytology
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Evaluate the Safety and Efficacy of TQB2858 Injection to the Subjects With Recurrent/Metastatic Nasopharyngeal Cancer
Status: UNKNOWN
Conditions: Recurrent / Metastatic Nasopharyngeal Cancer
Interventions: DRUG: TQB2858 Injection|DRUG: Anlotinib Hydrochloride Capsule|DRUG: Gemcitabine hydrochloride injection|DRUG: Cisplatin Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT