pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Clinical Trial of the Use of Tocilizumab for Treatment of SARS-CoV-2 Infection (COVID-19)
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Tocilizumab|DRUG: Hydroxychloroquine|DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Clinical and Pharmacoeconomic Impact of Rapid Diagnostic Test (Multiplex PCR FilmArray) on Antimicrobial Decision Making Compared to Conventional Decision Making Among Critically Ill Patients
Status: NOT_YET_RECRUITING
Conditions: Sepsis
Interventions: DIAGNOSTIC_TEST: rapid diagnostic test (multiplex PCR filmArray)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Mouthwash in Reducing Salivary Carriage of COVID-19
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: 0.5% Povidone Iodine|DRUG: 0.12% Chlorhexidine Gluconate Mouth Rinse|DRUG: 1% Hydrogen Peroxide|DRUG: 0.9% Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Cisplatin, Gemcitabine and Bevacizumab in Combination for Metastatic Transitional Cell Cancer
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: Cisplatin|DRUG: Gemcitabine|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Miswak Extract Toothpaste as Compared Potassium Nitrate in The Management of Dentinal Hypersensitivity
Status: UNKNOWN
Conditions: Dentine Hypersensitivity
Interventions: OTHER: Miswak extract-containing toothpaste|OTHER: Potassium nitrates-containing toothpaste|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Analgetic Effect of Nitrousoxide-oxygen Inhalation for Dental Treatment of Children
Status: COMPLETED
Conditions: Dental Pain|Muscle Sensitivity to Pressure|Skin Sensitivity to Electric Stimulation
Interventions: DRUG: Nitrousoxide-oxygen and atmospheric air|DRUG: Atmospheric air; nitrousoxide-oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Risk Factor Management in HIV Infection
Status: COMPLETED
Conditions: Coronary Heart Disease|Dyslipidemia|Diabetes Mellitus, Non-Insulin-Dependent|HIV Infection
Interventions: BEHAVIORAL: Updated CHD risk profiles|BEHAVIORAL: Guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Peer Support Network System Construction for the Primary Caregivers of Children With Biliary Atresia
Status: COMPLETED
Conditions: Biliary Atresia Congenital Type 3
Interventions: BEHAVIORAL: Peer support WeChat platform intervention|BEHAVIORAL: Routine nursing care group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intervention to Improve Shared Decision Making Among Seniors With Dementia, Their Caregivers and Healthcare Providers
Status: COMPLETED
Conditions: Dementia|Professional-Patient Relations|Professional-Family Relations|Aging
Interventions: BEHAVIORAL: Professional e-learning program on shared decision making
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Nicotine Lozenge or Tobacco-Free Snuff for Smokeless Tobacco Reduction
Status: COMPLETED
Conditions: Tobacco Dependence
Interventions: DRUG: nicotine lozenges|DRUG: tobacco-free snuff
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycemic Variability Comparing Two vs Six Meals in Type 2 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus Type 2|Overweight and Obesity|Meal Time
Interventions: OTHER: Comparing 3 versus 6 meals in type 2 diabetes patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Electromoxibustion and Knee Health Education for Knee Osteoarthritis in Older Adults
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Electromoxibustion|OTHER: Knee health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Online Revised Written Exposure Therapy for PTSD
Status: UNKNOWN
Conditions: PTSD|Subclinical PTSD
Interventions: BEHAVIORAL: written exposure therapy-revised version|BEHAVIORAL: minimal contact control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Targeting Left Ventricular Lead Position on the Rate of Response to Cardiac Resynchronization Therapy.
Status: COMPLETED
Conditions: Heart Failure, Congestive|Cardiac Pacing, Artificial|Defibrillators
Interventions: PROCEDURE: A|PROCEDURE: B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypnotic and Anti-nociceptive Components of Magnesium
Status: UNKNOWN
Conditions: Anesthesia
Interventions: DRUG: Magnesium sulfate IV|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cardiovascular Risk and Circadian Misalignment in Short Sleepers - Role of Extended Eating Period
Status: RECRUITING
Conditions: Sleep Deprivation
Interventions: BEHAVIORAL: Time restricted eating (TRE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Utrogestan Versus Nifedipine as Tocolysis for Preterm Labor: a Randomised Controlled Trial
Status: UNKNOWN
Conditions: Preterm Labor
Interventions: DRUG: utrogestan|DRUG: Nifedipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Modified Del Nido Versus Custodiol Cardioplegia For Myocardial Protection In Cardiac Surgery.
Status: COMPLETED
Conditions: Cardioplegia Solution Adverse Reaction
Interventions: DRUG: Modified Del Nido Versus Custodiol Cardioplegia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Everolimus in Patients With Tuberous Sclerosis Complex
Status: WITHDRAWN
Conditions: Facial Angiofibromas
Interventions: DRUG: Everolimus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Different Bed Head Heights on Patients After Rhinoplasty
Status: RECRUITING
Conditions: Rhinoplasty
Interventions: OTHER: the group with a bed head height of 45 degrees|OTHER: the group with a bed head height of 30 degrees
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Promoting Optimal Healing After Laceration Repair Study
Status: COMPLETED
Conditions: Neuralgia, Perineal
Interventions: PROCEDURE: Suturing of the perineal skin|PROCEDURE: Closing perineal skin with surgical glue|PROCEDURE: No suturing of the perineal skin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Machine Learning-driven Noninvasive Screening of Transcriptomics Liquid Biopsies for Early Diagnosis of Occult Peritoneal Metastases in Locally Advanced Gastric Cancer
Status: RECRUITING
Conditions: 1. Locally Advanced Gastric Cancer (LAGC): The Primary Condition Under Investigation is Locally Advanced Gastric Cancer, Which Refers to Stomach
Interventions: DIAGNOSTIC_TEST: Laparoscopic exploration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Coronary Xience V and the Cypher Select+ Stents in Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: Cypher Select plus|DEVICE: Xience V stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cut Down on Carbohydrate Usage in the Diet of Type 2 Diabetes. The Hypo-energetic Study
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: CRHP Diet|DIETARY_SUPPLEMENT: CD Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study To Estimate The Effects Of PD 0332334 On Lithium Pharmacokinetics In Healthy Subjects
Status: WITHDRAWN
Conditions: Generalized Anxiety Disease
Interventions: DRUG: Lithium|DRUG: PD 0332334|DRUG: Lithium|DRUG: PD 0332334
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer
Status: RECRUITING
Conditions: Neoplasms|Child|Adolescent
Interventions: DRUG: Ramucirumab|DRUG: Cyclophosphamide|DRUG: Vinorelbine|DRUG: Gemcitabine|DRUG: Docetaxel|DRUG: Abemaciclib|DRUG: Irinotecan|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aprepitant Triple Therapy for the Prevention of CINV in Nondrinking and Young Women Who Received Moderately Emetogenic Chemotherapy
Status: COMPLETED
Conditions: Gastrointestinal Neoplasms|Chemotherapy-induced Nausea and Vomiting
Interventions: DRUG: Aprepitant|DRUG: Palonosetron|DRUG: Dexamethasone|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Digital Image Correlation in Right Ventricular Evaluation
Status: COMPLETED
Conditions: Heart Ventricles
Interventions: DRUG: Theophylline|PROCEDURE: Ventilator positive end expiratory pressure adjustment|DEVICE: Videorecording
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: An Open Label, Multicenter Phase 2 Study of Durvalumab (MEDI4736) + Olaparib as Maintenance Therapy in Chinese
Status: UNKNOWN
Conditions: Lung Cancer|Small Cell Lung Cancer|Durvalumab
Interventions: DRUG: Durvalumab, etoposide, and cisplatin/carboplatin followed by durvalumab and olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk for Subsequent Osteoradionecrosis in A Transferred Fibula Flap in Head and Neck Cancer Patients Undergoing Segmental Mandibulectomy: a Cohort Study
Status: COMPLETED
Conditions: Head and Neck Cancer|Fibula Flap|Osteoradionecrosis|Mandibulectomy
Interventions: RADIATION: Radiotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Double-Blinded, Randomized, Placebo-Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Biochemical Activity of Intravenous Cpn10 Administration in Subjects With Mild to Moderate SLE.
Status: COMPLETED
Conditions: Lupus Erythematosus, Systemic
Interventions: BIOLOGICAL: Ala-Cpn10|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Mckenzie Method in Patients With Chronic Non-Specific Low Back Pain
Status: COMPLETED
Conditions: Non-specific Chronic Low Back Pain
Interventions: OTHER: Placebo|OTHER: McKenzie method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Dietary Fats on Vascular Parameters
Status: UNKNOWN
Conditions: Healthy
Interventions: OTHER: Coconut Oil|OTHER: Canola Oil|OTHER: Grapeseed Oil|OTHER: Chia Oil|OTHER: Butter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Pediatric Study to Evaluate Risk of Developing Essential Fatty Acid Deficiency When Receiving Clinolipid or Standard-of-Care Lipid Emulsion
Status: TERMINATED
Conditions: Essential Fatty Acid Deficiency (EFAD)
Interventions: DRUG: Clinolipid|DRUG: Intralipid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Hemodynamics of Albumin Versus Normal Saline in Cirrhosis
Status: SUSPENDED
Conditions: Cirrhosis|Ascites
Interventions: DRUG: 20% Human Albumin|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Decision Support for Heart Failure Prescribing
Status: NOT_YET_RECRUITING
Conditions: Decision Support Systems, Clinical|Heart Failure
Interventions: OTHER: Personalized Clinical Decision Support (CDS)|OTHER: Traditional Clinical Decision Support (CDS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: BPaL(M) Regimen for the Treatment of MDR/RR-TB
Status: RECRUITING
Conditions: Multidrug- and Rifampicin-resistant Tuberculosis
Interventions: DRUG: BPaL(M) regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigational Immuno-therapy Study of Nivolumab or Placebo in Participants With Resected Esophageal or Gastroesophageal Junction Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Cancer
Interventions: DRUG: Nivolumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Airway Obstruction in Infants With Lower Respiratory Infections
Status: COMPLETED
Conditions: Bronchiolitis|Respiratory Syncytial Virus Infections
Interventions: DRUG: Inhaled primatene will be given as a breathing treatment|OTHER: Nasal Washing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Piroxicam and Levonorgestrel Co-treatment for Emergency Contraception
Status: COMPLETED
Conditions: Emergency Contraception
Interventions: DRUG: Piroxicam 40 mg|DRUG: Levonorgestrel 1.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Double-blind Evaluation of Adverse Effects of Bath With Wipes Impregnated With 2% Chlorhexidine Versus Placebo
Status: COMPLETED
Conditions: Bed Bathing
Interventions: PROCEDURE: Standardization phase|PROCEDURE: Control bath|PROCEDURE: Bath with chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Side-to-side Duodenojejunostomy After Distal Duodenal Resection (DUORESECT)
Status: COMPLETED
Conditions: Duodenal Neoplasm|Gastrointestinal Disease|Surgery--Complications|Survival
Interventions: PROCEDURE: Duodenojejunostomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigation of Efficacy, Safety and Tolerability of Once and Twice Daily Doses of AZD1981 in Asthmatic Patients
Status: COMPLETED
Conditions: Asthma Patients
Interventions: DRUG: AZD1981|DRUG: AZD1981|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Triamcinolone With Pentoxifylline and Vitamin- E Efficacy in the Treatment of Stage 2 and 3 Oral Submucous Fibrosis
Status: COMPLETED
Conditions: Triamcinolone|Pentoxifylline|Vitamin E|Oral Submucosa Fibrosis|Tumor
Interventions: DRUG: Triamcinolone|DRUG: Pentoxifylline with Vitamin E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Docetaxel for Injection (Albumin-bound) in Patients With Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Docetaxel for injection (Albumin-bound)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug Metabolism
Status: NOT_YET_RECRUITING
Conditions: Drug Interaction
Interventions: DRUG: Caffeine Tablet|DRUG: Bupropion Hydrochloride Capsels|DRUG: Repaglinide Capsels|DRUG: Flurbiprofen Capsels|DRUG: Omeprazole 10 MG|DRUG: Dextromethorphan Oral Solution|DRUG: Midazolam oral solution|DRUG: Simvastatin tablets|DRUG: Placebo|DRUG: Carvedilol|DRUG: Diclofenac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Value of Molecular Residual Disease Monitoring Based on ctDNA in Borderline Resectable or Locally Advanced Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer|Locally Advanced
Interventions: DRUG: Later-line therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Tolerability of Oleogel-S-10 in Patients With Actinic Keratoses
Status: COMPLETED
Conditions: Actinic Keratoses
Interventions: DRUG: Oleogel-S10 100 mg/g|DRUG: Placebo (petroleum jelly)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety in Immunomodulatory Functions of Alemtuzumab (Campath) in Pediatric Kidney Transplantation Recipients
Status: COMPLETED
Conditions: Kidney Failure, Chronic|Kidney Transplantation|Immunosuppression
Interventions: DRUG: Alemtuzumab|DRUG: Tacrolimus|DRUG: Mycophenolate mofetil|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability and PK Study of AK0529 in Healthy Human
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: DRUG: AK0529|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study to Evaluate the Safety and Efficacy of APL-1202 as a Single-agent Oral Treatment Versus Intravesical Instillation of Epirubicin Hydrochloride in naïve Intermediate-risk NMIBC Patients
Status: RECRUITING
Conditions: Non-muscle Invasive Bladder Cancer
Interventions: DRUG: APL-1202|DRUG: Epirubicin Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRospective Observation of Aortic reGuRgitation aftEr TAVI and progreSS Over Time: PROGRESS PVL Registry
Status: COMPLETED
Conditions: Aortic Stenosis
Interventions: DEVICE: ACURATE neo™ Aortic Bioprosthesis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Memantine Hydrochloride for Treatment of Cognitive Dysfunction Due to Traumatic Brain Injury
Status: COMPLETED
Conditions: Treatment of Cognitive Deficits After Traumatic Brain Injury
Interventions: DRUG: Memantine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of Interleukin-7 (IL-7) and Bitherapy in Asiatic HCV Patients Resistant to Bitherapy
Status: UNKNOWN
Conditions: Hepatitis C
Interventions: DRUG: Interleukin-7
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Frequency Shock Wave Therapy for Improving Post-prostatectomy Erectile Dysfunction: a Prospective Pilot Study
Status: WITHDRAWN
Conditions: Erectile Dysfunction
Interventions: DEVICE: 8 bi-weekly LIESWT sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate The Performance of the Lucira Health All-In-One COVID-19 Test Kit vs Hologic Panther Fusion
Status: COMPLETED
Conditions: Covid19|SARS (Severe Acute Respiratory Syndrome)|Corona Virus Infection
Interventions: DEVICE: Lucira COVID-19 All-In-One test kit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Waldenstrom's Macroglobulinemia
Status: TERMINATED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|RADIATION: yttrium Y 90 ibritumomab tiuxetan
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Reduced-Intensity Allogeneic Hematopoietic Stem Cell Transplantation for Malignant Hematological Diseases
Status: COMPLETED
Conditions: Hematological Neoplasms|Hematopoietic Stem Cell Transplantation
Interventions: DRUG: Busulfex, Fludarabine, ALemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Examine the Effects of Child Life Interventions on Children's Anxiety Levels at Induction of Anesthesia
Status: COMPLETED
Conditions: Preoperative, Anxiety
Interventions: BEHAVIORAL: Child Life
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Plaque Removal Efficacy and Patient Acceptability of Knotted Floss Technique in Type I Gingival Embrasures
Status: COMPLETED
Conditions: Complication of Personal Oral Hygiene
Interventions: OTHER: Knotted floss technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial on Delay Phenomenon Utility in Preventing Anastomotic Leakage After an Esophagectomy
Status: COMPLETED
Conditions: Esophageal Anastomotic Leak
Interventions: PROCEDURE: delay phenomenon by arteriographic approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Postoperative Follow-up Via Text Messages Automated Versus Telephone in Patients With Continuous Regional Anesthesia
Status: COMPLETED
Conditions: Anesthesia|Regional Anesthesia|Nerve Pain
Interventions: OTHER: Tracking application app|OTHER: Telephone interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate a Single Intranasal Dose of STI-2099 (COVI-DROPS™) in Outpatient Adults With COVID-19 (US)
Status: COMPLETED
Conditions: Covid19
Interventions: BIOLOGICAL: COVI-DROPS|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Viral Therapy in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Light Chain Deposition Disease|Refractory Plasma Cell Myeloma
Interventions: OTHER: Diagnostic Laboratory Biomarker Analysis|BIOLOGICAL: Wild-type Reovirus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Anthocyanins From Aronia Extract in Healthy Men - a Pilot Study
Status: COMPLETED
Conditions: Bioavailability
Interventions: DIETARY_SUPPLEMENT: Aronia melanocarpa|DIETARY_SUPPLEMENT: Fermented Aronia Melanocarpa high dose|DIETARY_SUPPLEMENT: Fermented Aronia Melanocarpa low dose|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Robot-assisted Gait Training in Multiple Sclerosis Subjects
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Lokomat (Hocoma, Switzerland)|BEHAVIORAL: Conventional Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retrospective Study on the Prediction of Radiation-induced Brain Injury in Patients With Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma|Radiation-Induced Temporal Lobe Injury
Interventions: RADIATION: intensity-modulated radiotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Safety Study of Inactivated EV71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Adults, Children and Infants
Status: COMPLETED
Conditions: Hand, Foot and Mouth Disease
Interventions: BIOLOGICAL: 160Eu/0.5ml in adults|BIOLOGICAL: 320Eu/0.5ml in adults|BIOLOGICAL: 640Eu/0.5ml in adults|BIOLOGICAL: 1280Eu/0.5ml (without adjuvant) in 12 adults|BIOLOGICAL: 0Eu/0.5ml in adults|BIOLOGICAL: 160Eu/0.5ml in children|BIOLOGICAL: 320Eu/0.5ml in children|BIOLOGICAL: 640Eu/0.5ml in children|BIOLOGICAL: 1280Eu/0.5ml (without adjuvant) in children|BIOLOGICAL: 0Eu/0.5ml in children|BIOLOGICAL: 160Eu/0.5ml in infants|BIOLOGICAL: 320Eu/0.5ml in infants|BIOLOGICAL: 640Eu/0.5ml in infants|BIOLOGICAL: 1280Eu/0.5ml (without adjuvant) in infants|BIOLOGICAL: 0Eu/0.5ml in infants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Acute & Chronic Post-mastectomy Pain: Can PECS Block Alter the Geography?
Status: UNKNOWN
Conditions: Immediate and Chronic Pain After Mastectomy Managed With PECS Block or Local Infiltration
Interventions: OTHER: PECS block|OTHER: local infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Adipose-Derived Stem/Stromal Cells in Concussion and Traumatic Brain Injuries
Status: WITHDRAWN
Conditions: Traumatic Encephalopathies, Chronic|Concussion, Mild|Concussion, Intermediate|Concussion, Severe|Concussion, Brain
Interventions: PROCEDURE: Microcannula Harvest Adipose|DEVICE: Centricyte 1000|PROCEDURE: Sterile Normal Saline IV deployment AD-cSVF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Colistin to Prevent Pediatric Ventilator-associated Pneumonia
Status: NOT_YET_RECRUITING
Conditions: Ventilator Associated Pneumonia
Interventions: DRUG: colistimethate sodium|DRUG: 0.9% Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: S9908: Glutamine in Treating Mucositis Caused by Radiation Therapy in Patients With Newly Diagnosed Cancer of the Mouth or Throat
Status: TERMINATED
Conditions: Cancer-related Problem/Condition|Head and Neck Cancer|Pain
Interventions: DIETARY_SUPPLEMENT: glutamine|RADIATION: radiation therapy|DRUG: l-glutamine placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Food Effect of Oral HRS5091 in Healthy Subjects and Chronic Hepatitis B Patients
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: HRS5091
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Metformin and Vascular Function in Prediabetes
Status: NOT_YET_RECRUITING
Conditions: PreDiabetes
Interventions: DRUG: Metformin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Ixabepilone in Patients With HER-2 Negative Metastatic Breast Cancer (HIT)
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: ixabepilone|DRUG: ixabepilone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iron Babies Pilot Supplementation Trial
Status: COMPLETED
Conditions: Iron-deficiency|Anaemia in Early Infancy
Interventions: DIETARY_SUPPLEMENT: Iron drops/Ferrous sulphate|DIETARY_SUPPLEMENT: Placebo drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Study to Evaluate Efficacy and Safety of Celecoxib Capsule in Hand Osteoarthritis Patients
Status: COMPLETED
Conditions: Osteoarthritis Hand
Interventions: DRUG: Celecoxib 100 MG|DRUG: Celecoxib 200mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Is Laparoscopic Excision for Peritoneal Endometriosis Helpful or Harmful?
Status: RECRUITING
Conditions: Endometriosis; Peritoneum
Interventions: OTHER: Laparoscopy with excision|OTHER: Laparoscopy without excision|OTHER: Medical treatment-as-usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Preoperative Olanzapine on Quality of Recovery After Discharge From Ambulatory Surgery
Status: RECRUITING
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Olanzapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Palate Wound Healing and Pain Perception of De-epthelized Ctg vs Sub-epithelial Ctg
Status: COMPLETED
Conditions: Palate; Wound
Interventions: PROCEDURE: DFGG|PROCEDURE: SCTG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of BGB-11417 in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: RECRUITING
Conditions: Leukemia|Lymphoma|Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma|Small Lymphocytic Lymphoma|Relapsed Chronic Lymphocytic Leukemia
Interventions: DRUG: BGB-11417
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Nutritional Supplementation and Pulmonary Rehabilitation on the Clinical Status of HF and COPD
Status: UNKNOWN
Conditions: Heart Failure|Copd|Nutritional Supplementation|Pulmonary Rehabilitation
Interventions: DIETARY_SUPPLEMENT: Nutritional supplementation and Pulmonary Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study To Observe Safety And Blood Concentrations Of PF-06412562 During And Following The Oral Administration Of Multiple Doses Of PF-06412562 In Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 3 mg PF-06412562|DRUG: 10 mg PF-06412562|DRUG: 25 mg PF-06412562|DRUG: PF-06412562 TBD mg|DRUG: PF-06412562 TBD mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Influence of Capsular Tension Ring on IOL-capsular Complex After Cataract Surgery in Patients With High Myopia: a Clinical Observation Based on SS-OCT
Status: UNKNOWN
Conditions: High Myopia|Capsular Tension Ring
Interventions: PROCEDURE: Cataract surgery with IOL implantation and with/without capsular tension ring implatation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First in Human Study of RT001 in Patients With Friedreich's Ataxia
Status: COMPLETED
Conditions: Friedreich's Ataxia
Interventions: DRUG: Low dose cohort|DRUG: High dose cohort
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of Melt Organic Baking Fat for Reducing Child Obesity
Status: COMPLETED
Conditions: Obesity|Overweight|Pediatric Obesity
Interventions: DIETARY_SUPPLEMENT: Melt Test Blend 3.2|DIETARY_SUPPLEMENT: Corn Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Escalation Study of Cabozantinib in Combination With Lutetium-177 (177Lu)-PSMA-617 in Patients With Metastatic Castration-Resistant Prostate Cancer
Status: RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin/Mineral Absorption From Two Different Supplements
Status: COMPLETED
Conditions: Healthy Nutrition
Interventions: DIETARY_SUPPLEMENT: Multivitamin/mineral supplement A|DIETARY_SUPPLEMENT: Multivitamin/mineral supplement B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of Dotatate Imaging in Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer Stage IV
Interventions: DRUG: Gallium-68 DOTATATE|DRUG: Copper-64 DOTATATE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Thalidomide and Doxil® in Patients With Androgen Independent Prostate Cancer (AIPC)
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Thalidomide|DRUG: Doxil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vertebral Body Sparing Craniospinal Irradiation for Pediatric Patients With Cancer of the Central Nervous System
Status: COMPLETED
Conditions: Malignant Central Nervous System Neoplasm
Interventions: PROCEDURE: Intensity-Modulated Proton Therapy|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IVIG With Rituximab vs Rituximab as First Line Treatment of Pemphigus
Status: ACTIVE_NOT_RECRUITING
Conditions: Pemphigus
Interventions: DRUG: Rituximab|OTHER: IVIg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ARO-RAGE in Healthy Subjects
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: ARO-RAGE Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prostate Cancer Subclinical Metastatic Ablative MR-guided Radiotherapy
Status: RECRUITING
Conditions: Post Prostatectomy
Interventions: DIAGNOSTIC_TEST: [18F]DCFPyL PET/MRI scan|RADIATION: Stereotactic Ablative Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Role of LIDOCAINE IN Pediatric Cochlear Implant Surgery
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Lidocaine|OTHER: Na CL 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Non-surgical Electrolytic Cleaning Peri-implantitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Peri-Implantitis
Interventions: BEHAVIORAL: Implant hygiene instructions and removal of the prosthesis|PROCEDURE: Non-surgical peri-implantitis treatment /microsurgery|PROCEDURE: Implant surface decontamination 1(ultrasonic device)|PROCEDURE: Implant surface decontamination 2 (air polishing)|PROCEDURE: Implant surface decontamination 3 (electrolytic cleaning)|DRUG: Antibiotic treatment (Metronidazole)|PROCEDURE: Modification and polishing of the prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OptiMized REsistaNt Starch in Inflammatory Bowel Disease: The MEND Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn Disease|Ulcerative Colitis|Inflammatory Bowel Diseases
Interventions: OTHER: Resistant Starch|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: IDB Injection Combined With PTNS for Managing Children With OAB Not Responding to Monotherapy
Status: COMPLETED
Conditions: BOTOX|Percutaneous Tibial Nerve Stimulation
Interventions: DRUG: Solifenacin group|PROCEDURE: Percutaneous tibial nerve stimulation group|DRUG: Intradetrusor BOTOX group|COMBINATION_PRODUCT: Intradetrusor BOTOX combined with Percutaneous tibial nerve stimulation group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IRB-HSR# 14296 The Use of the Intrathoracic Pressure Regulator (ITPR) to Improve Systemic Blood Pressure in Patient Undergoing CABG Surgery
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: ITPR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Influence of Pioglitazone for Renal Transplant Function in Diabetics
Status: COMPLETED
Conditions: Diabetes Mellitus|Kidney Transplantation|Proteinuria
Interventions: DRUG: pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Antibacterial Effect of Guava Leaves Extract Mouthwash Compared to Chlorhexidine Mouthwash in High Caries Risk Patients
Status: UNKNOWN
Conditions: High Caries Risk Patients|Antimicrobial Effect|Salivary pH|Patient Satisfaction to Taste
Interventions: DRUG: Guava leaves extract|DRUG: Chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pain Management of Pecto-intercostal Fascial Block Versus Intravenous Fentanyl After Pediatric Cardiac Surgery
Status: UNKNOWN
Conditions: Pediatric Patients|Congenital Heart Surgery
Interventions: OTHER: Ultrasound-guided bilateral pecto-intercostal fascial block|DRUG: Intravenous fentanyl|DRUG: Propofol|DRUG: Sevoflurane|DRUG: Atracurium|DEVICE: ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics of JZP441 in Healthy Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: JZP441|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Proof of Concept Study to Evaluate Exosomes From Human Mesenchymal Stem Cells in Women With Premature Ovarian Insufficiency (POI)
Status: RECRUITING
Conditions: Premature Ovarian Insufficiency|Diminished Ovarian Reserve
Interventions: DRUG: VL-PX10
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACVDL Treatment for Patients With Newly Diagnosed Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Doxorubicin|DRUG: Bortezomib|DRUG: Lenalidomide|DRUG: Dexamethasone|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Written Disclosure Therapy for Anxiety and Stress in Patients With Chronic Lung Disease
Status: COMPLETED
Conditions: Chronic Lung Diseases|COPD|Pulmonary Fibrosis
Interventions: OTHER: Disclosure Writing (Written Disclosure Therapy)|OTHER: Neutral (Sham) Writing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Intravenous (IV) Ganaxolone in Women With Postpartum Depression
Status: COMPLETED
Conditions: Depression|Depressive Disorder|Depression, Postpartum|Behavioral Symptoms|Mood Disorders|Mental Disorders|Puerperal Disorders|Pregnancy Complications|Postpartum|PPD
Interventions: DRUG: Ganaxolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Frostbite Sequelae With Botulinum Toxin A
Status: WITHDRAWN
Conditions: Cold Hypersensitivity|Vascular System Injuries|Vibration; Disorder|Sensory Disorders|Pain, Nerve
Interventions: DRUG: Botuinum toxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Acute Effect of Cold Spray Application on the Mechanical Properties of the Quadriceps Muscle in Athletes
Status: UNKNOWN
Conditions: Cold|Spray|Muscle|Athletic Injuries
Interventions: OTHER: Clorethyl cold spray® (Vapocoolant spray)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Haploidentical Transplantation With Pre-Transplant Immunosuppressive Therapy for Patients With Sickle Cell Disease
Status: RECRUITING
Conditions: Sickle Cell Disease
Interventions: BIOLOGICAL: Hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prediction and Prognostic Analysis of Liver Abscess Formation After Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma (CHANCE 2407)
Status: NOT_YET_RECRUITING
Conditions: TACE|HCC - Hepatocellular Carcinoma|Liver Abscess
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Autologous CD22 CAR T Cells Following Commercial CD19 CAR T Cells in B Cell Malignancies
Status: RECRUITING
Conditions: Leukemia|Acute Lymphoblastic Leukemia
Interventions: DRUG: CD22CART infusion|DRUG: Tisagenlecleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ad5FGF-4 In Patients With Refractory Angina Due to Myocardial Ischemia
Status: NOT_YET_RECRUITING
Conditions: Angina, Stable
Interventions: BIOLOGICAL: Ad5FGF-4|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxidative Stress and Opiorphin in Temporomandibular Disorders
Status: UNKNOWN
Conditions: Temporomandibular Disorders
Interventions: DEVICE: stabilization splint|DRUG: Placebo Oral Tablet|DEVICE: placebo splint|DIETARY_SUPPLEMENT: Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Injection Rate of Local Anesthetic in Caesarean Section
Status: COMPLETED
Conditions: Anesthesia, Spinal|Anesthesia, Obstetrical
Interventions: OTHER: Local anesthetic injection rate in spinal anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Venezuelan Equine Encephalitis Monovalent Virus-Like Particle Vaccine
Status: UNKNOWN
Conditions: Encephalitis|Encephalitis, Viral|Infectious Encephalitis|Virus Diseases|Encephalomyelitis, Venezuelan Equine|Brain Diseases|Central Nervous System Diseases|Central Nervous System Viral Diseases|Alphavirus Infections|Togaviridae Infections|RNA Virus Infections|Central Nervous System Infections|Encephalomyelitis|Physiological Effects of Drugs|Vaccines|Encephalomyelitis, Equine|Nervous System Diseases
Interventions: BIOLOGICAL: Vaccinations on Day 0, Day 28, and Day 140
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION