pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Ketones for Pulmonary Hypertension - Effects on Hemodynamics
Status: COMPLETED
Conditions: Pulmonary Hypertension|Ketonemia
Interventions: DIETARY_SUPPLEMENT: Hyperketonemia - use of ketone (3-OHB) infusion|DIETARY_SUPPLEMENT: Placebo - use of saline infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Personalised Risk scOre For Implantation of Defibrillators in Patients With Reduced LVEF≤35% and a Low Risk for Sudden Cardiac Death
Status: WITHDRAWN
Conditions: Myocardial Infarction|Heart Failure|Sudden Cardiac Death
Interventions: DRUG: Optimal Medical Therapy (OMT)|DEVICE: Implantable cardioverter-defibrillator (ICD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Bifurcation Lesions by SINGLE STENT and KISSing Balloon Trial
Status: COMPLETED
Conditions: Ischemic Heart Disease|Restenosis
Interventions: DEVICE: Sirolimus-eluting coronary stent (Cypher)|DEVICE: Paclitaxel-eluting stent (TAXUS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuroimaging GABA Physiology in Fragile X Syndrome
Status: TERMINATED
Conditions: Fragile X Syndrome (FXS)|Idiopathic Intellectual Developmental Disorder (IDD)
Interventions: DRUG: [18F]flumazenil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prospective Clinical Evaluation of ASR and ReCap Resurfacing Arthroplasty
Status: COMPLETED
Conditions: Patients Suitable for THA
Interventions: DEVICE: ASR hip prosthesis|DEVICE: ReCap hip prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Operative Treatment With Ketorolac After Abdominal Myomectomy
Status: COMPLETED
Conditions: Febrile Morbidity|Pain
Interventions: DRUG: ketorolac|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Reducing Knee Compression When Sleeping in Those With Knee OA
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: BEHAVIORAL: Change in sleeping position|BEHAVIORAL: No change in sleeping position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation of a Pain Management Protocol for Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Replacement, Total
Interventions: DRUG: Bupivicaine|DRUG: Fentanyl|DRUG: Epimorphine|DRUG: Normal Saline|DRUG: Normal Saline|DRUG: Normal Saline|DRUG: Ropivicaine|DRUG: Epinephrine|DRUG: Ketorolac|DRUG: Ropivicaine with Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Conspicuity of Masses and Architectural Distortions Between Wide- and Narrow-angle Digital Breast Tomosynthesis Systems
Status: NOT_YET_RECRUITING
Conditions: Architectural Distortions|Breast Tomosynthesis
Interventions: DEVICE: Digital Breast Tomosynthesis (DBT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Do PA Interventions Increase Acute Medical Inpatients PA Levels
Status: COMPLETED
Conditions: Physical Activity|Moving Medicine|Acute Medical Unit
Interventions: BEHAVIORAL: 'More minutes' conversation (Moving medicine)|BEHAVIORAL: 'one minute' conversation (Moving medicine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: VASER-Assisted Lipoplasty Compared With Suction-Assisted Lipoplasty
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Suction-assisted Lipoplasty|DEVICE: VASER-assisted lipoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Use of Functional Near-infrared Spectroscopy to Investigate Role of Human Auditory Cortex Plasticity and Multi-sensory Integration on Cochlear Implant Performance After Single-sided Deafness
Status: NOT_YET_RECRUITING
Conditions: Hearing Loss
Interventions: PROCEDURE: FNIRS Observational
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SWOG-S9635 Fluorouracil Plus Ethynyluracil in Advanced Colorectal Cancer Not Responded to Fluorouracil
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: ethynyluracil|DRUG: fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postprandial Blood Glucose Control With BioChaperone® Combo and Insulin Lispro (Humalog®) Mix 25 in People With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Biochaperone® Combo|DRUG: Humalog® Mix25
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stress and Feeding (SAFE): A Pilot Intervention for Mothers and Their Preterm Infants
Status: COMPLETED
Conditions: Feeding Behavior|Preterm Infant|Stress|Mother-Infant Interaction
Interventions: BEHAVIORAL: Stress and Feeding (SAFE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Identify the Optimal TMS Target to Modulate Reward Activity
Status: RECRUITING
Conditions: Nicotine Use Disorder
Interventions: DEVICE: Active 10-Hz TMS to the DLPFC|DEVICE: Sham TMS-DLPFC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Oral Antiseptic Gargles on the Oral Cavity Microbiome
Status: COMPLETED
Conditions: Oral Health
Interventions: DRUG: 1% Betadine® PVP-I based mouth wash and gargle,|DRUG: 0.2% Chlor-Rinse™ Chlorhexidine based mouth wash|DRUG: Normal saline gargle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Combination Dexmedetomidine Added to Fentanyl-based Intravenous Patient-controlled Analgesia on Nausea Vomiting in Highly Susceptible Patients Undergoing Lumbar Spinal Surgery: Prospective Double Blinded Randomized Controlled Trial
Status: COMPLETED
Conditions: PONV
Interventions: DRUG: dexmedetomidine|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder|Depression|Alcohol-Related Disorders|Suicidal Ideation|Substance-Related Disorders|Mild Cognitive Impairment|Quality of Life|Pain|Wounds and Injury|Brain Injuries|Chronic Disease
Interventions: BEHAVIORAL: Motivational Interviewing|BEHAVIORAL: Cognitive Behavioral Therapy Elements|BEHAVIORAL: Care Management|DRUG: Fluoxetine|DRUG: Fluvoxamine|DRUG: Paroxetine|DRUG: Sertraline|DRUG: Citalopram|DRUG: Venlafaxine|DRUG: Duloxetine|DRUG: Mirtazapine|DRUG: Diphenhydramine|DRUG: Trazodone|DRUG: Prazosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: POCone-UBiT-IR300 Pediatric Comparison Study
Status: COMPLETED
Conditions: Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
Interventions: OTHER: Pranactin citric solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Subcutaneous INFIX and EXFIX for Anterior Pelvic Ring Fractures Requiring Stabilization
Status: TERMINATED
Conditions: Anterior Pelvic Ring Fractures
Interventions: PROCEDURE: Internal Fixator|PROCEDURE: External fixator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prehabilitation During Neoadjuvant Chemoradiotherapy for Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: BEHAVIORAL: Physical exercise|DIETARY_SUPPLEMENT: Nutrition supplement|BEHAVIORAL: Mental support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect Of Pressure Biofeedback on Deep Cervical Muscle Training Among University Teachers.
Status: COMPLETED
Conditions: Neck Pain
Interventions: DEVICE: Pressure biofeedback|OTHER: Conventional exercises for deep cervical muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide and Dinutuximab With or Without Isotretinoin in Treating Younger Patients With Refractory or Recurrent Neuroblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Neuroblastoma|Refractory Neuroblastoma
Interventions: BIOLOGICAL: Dinutuximab|DRUG: Isotretinoin|OTHER: Laboratory Biomarker Analysis|DRUG: Lenalidomide|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety, Tolerability and Pharmacokinetics of ALN-TTR02 in Japanese Healthy Volunteers
Status: COMPLETED
Conditions: Transthyretin (TTR)-Mediated Amyloidosis
Interventions: DRUG: patisiran (ALN-TTR02)|DRUG: Sterile Normal Saline (0.9% NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of GSK1265744 on Cardiac Conduction
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: GSK1265744|DRUG: GSK1265744 matching placebo|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Tesmilifene (YMB1002) Plus Epirubicin and Cyclophosphamide in Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic/Recurrent Breast Cancer
Interventions: DRUG: Tesmilifene (YMB 1002)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preimplantation Genetic Testing for Aneuploidy Counseling
Status: ACTIVE_NOT_RECRUITING
Conditions: Patient Education
Interventions: OTHER: Handout on PGT-A|OTHER: Handout on PGT-A and genetic counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Role of Airwayultrasound in Predicting Difficult Endotracheal Intubation in Patients Undergoing General Anesthesia
Status: NOT_YET_RECRUITING
Conditions: Predict Diificult Endotracheal Intubation
Interventions: DEVICE: assesment of difficult endotracheal intubation by airway ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Open Label Study to Evaluate Daratumumab in Participants With Moderate to Severe Systemic Lupus Erythematosus
Status: UNKNOWN
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Daratumumab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Far Infrared Therapy on AV Fistula Flow, Endothelial Function and Echocardiography in ESRD Patients
Status: UNKNOWN
Conditions: End Stage Renal Disease
Interventions: DEVICE: WSTM TY101 FIR emitter (Far infrared therapy)|OTHER: no intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Food Labeling Influence Long-term Food Intake and Eating-related Variables in Women?
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Nutrient-label|BEHAVIORAL: Calorie-label|BEHAVIORAL: No label
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: A Single Dose, Cross-over Bioequivence Study Comparing Galantamine IR (Immediate Release) Table and Galantmine OS (Oral Solution) in Healthy Volunteers
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Galantamine oral solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Ad-RTS-hIL-12 + Veledimex in Subjects With Recurrent or Progressive Glioblastoma, a Substudy to ATI001-102
Status: COMPLETED
Conditions: Glioblastoma
Interventions: BIOLOGICAL: Ad-RTS-hIL-12|DRUG: veledimex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Nitrate and Nitrite to Increase Nitric Oxide in Patients With Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Arteriosclerosis
Interventions: PROCEDURE: Forearm blood flow study|PROCEDURE: Brachial artery reactivity study|PROCEDURE: Treadmill exercise test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease|Pulmonary Hypertension|Dyspnea
Interventions: DRUG: Tadalafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Mycosis Fungoides With Hypericin Ointment and Visible Light
Status: RECRUITING
Conditions: Cutaneous T Cell Lymphoma|Mycosis Fungoides
Interventions: DRUG: Hypericin|OTHER: Visible Light
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TENS Effectiveness and Knee Osteoarthritis in Humans
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: High Frequency TENS|PROCEDURE: Low frequency TENS|PROCEDURE: Placebo TENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women
Status: COMPLETED
Conditions: Uterine Fibroids|Heavy Menstrual Bleeding
Interventions: DRUG: Elagolix|DRUG: Placebo for Estradiol/Norethindrone Acetate|DRUG: Estradiol/Norethindrone Acetate|DRUG: Placebo for Elagolix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Blackcurrant Supplementation on Eye Health
Status: COMPLETED
Conditions: Eye Strain|Eye Fatigue
Interventions: DIETARY_SUPPLEMENT: Blackcurrant|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Food Study of Letrozole Tablets 2.5 mg and Femara® Tablets 2.5 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Letrozole Tablets 2.5 mg|DRUG: Femara® Tablets 2.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Researching an Effect of GLP-1 Agonist on Liver STeatosis (REALIST)
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|NASH - Nonalcoholic Steatohepatitis
Interventions: DRUG: dulaglutide (TRULICITY®) 1.5 mg|OTHER: reinforced dietary monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SPACE MAINTAINERS EFFECTS ON ORAL MİCROFLORA
Status: COMPLETED
Conditions: Orthodontic Appliance Complication|Lactobacillus Infection|Dental Caries in Children|Streptococcus, Other Specified Group
Interventions: OTHER: The Salivary pH measured|OTHER: The saliva flow rate was measured|OTHER: Streptococcus mutans and Lactobacillus counts in saliva were measured
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluate the Efficacy and Safety of MUSK Pill on Coronary Microvascular Dysfunction
Status: UNKNOWN
Conditions: Angina Pectoris|Coronary Heart Disease|X Syndrome, Angina|Non Obstructive Coronary Artery Disease
Interventions: DRUG: MUSK pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Outcomes Between Open Wedge High Tibial Osteotomy and Double Level Osteotomy in Antromedial Knee Arthritis With Extra Articular Deformity
Status: NOT_YET_RECRUITING
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Open Wedge High Tibial Osteotomy|PROCEDURE: Double Level Osteotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Daxdilimab (HZN-7734) for the Treatment of Systemic Lupus Erythematosus in an Open-label Extension Study
Status: TERMINATED
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: Daxdilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparability of Keratometry of VERION Image Guided System With Established Measuring Devices
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Slit lamp|DEVICE: Autorefractor|DEVICE: IOLMaster 500|DEVICE: Pentacam HR|DEVICE: LenStar LS900|DEVICE: VERION Image Guided System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Dasatinib (BMS-354825) in Patients With Advanced 'Triple-negative' Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Metastasis
Interventions: DRUG: Dasatinib|DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protocol of Assistance to Patients With Covid-19 Submitted to Treatment With HD-tDCS
Status: UNKNOWN
Conditions: Coronavirus|COVID-19 Respiratory Infection
Interventions: OTHER: Active HD-tDCS 3mA|OTHER: Sham HD-tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pneumococcal Pneumonia Vaccine Series (PCV20 and PPSV23) in Patients With Chronic Lymphocytic Leukemia Associated Immunodeficiency, PROTECT CLL Trial
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: BIOLOGICAL: Pneumococcal 20-valent Conjugate Vaccine|BIOLOGICAL: Pneumococcal Polyvalent Vaccine|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ 73763989+JNJ 56136379+Nucleos(t)Ide Analog (NA) Regimen Compared to NA Alone in e Antigen Negative Virologically Suppressed Participants With Chronic Hepatitis B Virus Infection
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: JNJ-73763989|DRUG: JNJ-56136379|DRUG: Placebo for JNJ-73763989|DRUG: Placebo for JNJ-56136379|DRUG: Entecavir (ETV) monohydrate|DRUG: Tenofovir disoproxil fumarate (TDF)|DRUG: Tenofovir alafenamide (TAF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TMS and Exposure Therapy
Status: TERMINATED
Conditions: Arachnophobia|Phobia
Interventions: DEVICE: Intermittent Theta Burst Stimulation (iTBS), Ventromedial Prefrontal Cortex (vmPFC)|DEVICE: Intermittent Theta Burst Stimulation (iTBS), vertex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Fasting Study in Patients
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Asenapine Sublingual Tablets 10 mg|DRUG: Asenapine Sublingual Tablets 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RIGHT: Rhythm ID Going Head-to-Head Trial
Status: COMPLETED
Conditions: Tachycardia
Interventions: DEVICE: VITALITY 2 Implantable Cardioverter Defibrillator|DEVICE: Medtronic Implantable Cardioverter Defibrillator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: EXPLORE MRace: Early Feasibility Experience of Posterior Leaflet Restoration to Reduce Mitral Regurgitation Using the MRace Implant
Status: NOT_YET_RECRUITING
Conditions: Mitral Valve Disease
Interventions: DEVICE: Transcatheter mitral valve repair (MRace Implant and Delivery System)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Allogeneic γ9δ2 T Cells Treatment of Recurrent Hematologic Tumors
Status: RECRUITING
Conditions: Hematologic Diseases
Interventions: BIOLOGICAL: allogeneic γ9δ2 T Cells|DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Zoredronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Skeletal Targeted Radiotherapy Using Holmium-166-DOTMP in Patients With Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Holmium-166-DOTMP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Efficacy of Serratus Anterior Plane Block in The Rib Fractures Pain
Status: COMPLETED
Conditions: Serratus Plane Block
Interventions: PROCEDURE: Serratus Plane Block|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First Line Radiofrequency Ablation Versus Antiarrhythmic Drugs for Atrial Fibrillation Treatment (The RAAFT Study)
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Pulmonary Vein Isolation performed by Catheter Ablation|DRUG: Conventional Antiarrhythmic Drug Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Session Spine Stereotactic Radiosurgery in Metastatic Epidural Spinal Cord Compression
Status: COMPLETED
Conditions: Metastatic Epidural Spinal Cord Compression
Interventions: PROCEDURE: Stereotactic Radiosurgery (SSRS)|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Administration of Fostamatinib on Blood Concentrations of Digoxin in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers|Rheumatoid Arthritis
Interventions: DRUG: Digoxin|DRUG: Fostamatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Promoting Continuous Positive Airway Pressure (CPAP) Adherence
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: BEHAVIORAL: Web-based Access to CPAP Data|BEHAVIORAL: Web-based Access to CPAP Data with Financial Incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Acute Coronary Syndrome and Nurse Counselling
Status: COMPLETED
Conditions: Acute Myocardial Infarction|Coronary Artery Disease
Interventions: OTHER: nursing counceling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study on the Dose-response Relationship of Pharmacodynamic Parameters in Patients With Hemophilia With Inhibitors
Status: COMPLETED
Conditions: Hemophilia A With Inhibitor|Hemophilia B With Inhibitor
Interventions: BIOLOGICAL: Eptacog alfa, activated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults
Status: NOT_YET_RECRUITING
Conditions: Frailty|Mild Cognitive Impairment|Aging
Interventions: DRUG: Mitoquinone Mesylate|DIETARY_SUPPLEMENT: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Capsaicin Patch 8 % for the Treatment of Persistent Pain After Inguinal Herniotomy
Status: TERMINATED
Conditions: Persistent Pain After Inguinal Herniotomy
Interventions: DRUG: capsaicin patch (qutenza)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Restricting the Use of Artesunate Plus Amodiaquine Combination Therapy to Malaria Cases Confirmed by a Dipstick Test: A Cluster Randomised Control Trial
Status: COMPLETED
Conditions: Malaria
Interventions: DEVICE: RDT|OTHER: Clinical Judgement as basis for treatment of malaria with ACT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Musashino Diabetes Diet in Type II Diabetes Mellitus Disease
Status: COMPLETED
Conditions: Type II Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Musashino T2DM diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pilot Study Evaluating the Success (= Safe Decannulation) of a Standardized Tracheotomy Weaning Procedure in Brain-injury's Patients
Status: COMPLETED
Conditions: Tracheostomy|Brain Injuries
Interventions: PROCEDURE: Standardized 5-step weaning procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sodium Picosulphate/Magnesium Citrate and Low-volume PEG -Ascorbic Acid as Preparation for Colonoscopy
Status: COMPLETED
Conditions: Colon Cleansing for Colonoscopy
Interventions: DRUG: sodium picosulphate magnesium citrate|DRUG: low-volume PEG -ascorbic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Analgesia With EMLA and Glucose Oral Solution
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: EMLA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dose-Finding Study to Evaluate the Safety, Efficacy, & Tolerability of Multiple Doses of rAvPAL-PEG in Subjects With PKU
Status: COMPLETED
Conditions: Phenylketonuria
Interventions: DRUG: rAvPAL-PEG 0.001 mg/kg|DRUG: rAvPAL-PEG 0.003 mg/kg|DRUG: rAvPAL-PEG 0.01 mg/kg|DRUG: rAvPAL-PEG 0.03 mg/kg|DRUG: rAvPAL-PEG 0.1 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The INVIGORATE 2 Trial: A Clinical Trial to Assess the Efficacy and Safety of Subjects With Seasonal Allergic Conjunctivitis
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: Reproxalap Ophthalmic Solution (0.25%)|DRUG: Vehicle Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IO102-IO103 in Combination With Pembrolizumab Versus Pembrolizumab Alone in Advanced Melanoma (IOB-013 / KN-D18)
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Melanoma|Unresectable Melanoma
Interventions: DRUG: IO102-IO103|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypoxic-Ischemic Encephalopathy Therapy Optimization in Neonates for Better Neuroprotection With Inhalative CO2
Status: COMPLETED
Conditions: Hypoxic-Ischaemic Encephalopathy|Perinatal Asphyxia|Hypocapnia
Interventions: OTHER: 5% carbon-dioxide inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Oxygen Therapy for Adult Onset Post Traumatic Stress Disorder
Status: COMPLETED
Conditions: Ptsd
Interventions: DEVICE: Hyperbaric oxygen-90 minutes exposure to 100% oxygen at 2 ATA, with 5-minute air breaks every 20 minutes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical PluroGel PN for the Treatment of Mildly Infected Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot Ulcer|Infection
Interventions: DRUG: Plurogel PN
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pirfenidone in Patient With Dermatomyositis Interstitial Lung Disease (Dm-ILD)
Status: UNKNOWN
Conditions: Dermatomyositis Interstitial Lung Disease (Dm-ILD)
Interventions: DRUG: Pirfenidone|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Etoricoxib to Treat Chronic Low Back Pain (0663-041)
Status: COMPLETED
Conditions: Recurrent Low Back Pain
Interventions: DRUG: MK0663, Etoricoxib / Duration of Treatment : 12 Weeks|DRUG: Comparator : placebo (unspecified) /Duration of Treatment : 12 Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Hair Stimulating Complex (HSC) in Female Pattern Hair Loss
Status: UNKNOWN
Conditions: Alopecia
Interventions: BIOLOGICAL: Hair Stimulating Complex (HSC)|OTHER: Phosphate Buffered Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bivalirudin Versus Enoxaparin in Critically Ill COVID-19 Patients
Status: COMPLETED
Conditions: Acute Respiratory Failure|SARS CoV 2 Infection|Anticoagulants
Interventions: DRUG: Enoxaparin Sodium|DRUG: Bivalirudin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Fibroadenoma
Interventions: DEVICE: Ultrasonic ablation device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VasoStar Vibrational Guidewire System to Facilitate Crossing Coronary Artery Chronic Total Occlusions
Status: NOT_YET_RECRUITING
Conditions: Chronic Total Occlusion of Coronary Artery|Chronic Angina
Interventions: DEVICE: VasoStar guidewire system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Re-exposure of Human Volunteers to a Heterologous Strain of P. Falciparum Sporozoites
Status: COMPLETED
Conditions: Malaria, Falciparum
Interventions: BIOLOGICAL: Heterologous challenge|DRUG: Malarone treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Somatostatin Receptors and GH Receptor Expression on Bone of Acromegalic Patients (ACRO-BONE)
Status: COMPLETED
Conditions: Evaluation of the Expression of Somatostatin Receptors and GH Receptor on Bone of Acromegalic Patients
Interventions: PROCEDURE: Trans-sphenoidal surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Precision Medicine Approach for Early Dementia & Mild Cognitive Impairment
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Dementia, Mild
Interventions: DIETARY_SUPPLEMENT: Precision Medicine Approach|COMBINATION_PRODUCT: Hormones and Medications tailored to lab tests, combined with devices that support stress management and brain exercises|BEHAVIORAL: Standard-of-Care|BEHAVIORAL: Lifestyle including diet, exercise, stress management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Safety Study of Vemurafenib Followed by Ipilimumab in Subjects With V600 BRAF Mutated Advanced Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Ipilimumab|BIOLOGICAL: Vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Remifentanil-induced Postoperative Hyperalgesia With Intravenous Ibuprofen
Status: COMPLETED
Conditions: Ibuprofen|Remifentanil|Hyperalgesia|Pain, Postoperative
Interventions: DRUG: high dose remifentanil|DRUG: Ibuprofen|DRUG: low dose remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Abdominal Aortic/Aorto-Iliac Aneurysm Endoluminal Graft Study
Status: UNKNOWN
Conditions: Aortic Aneurysm
Interventions: DEVICE: Endoluminal Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety and Efficacy of Long-term Dosing of Romiplostim in Thrombocytopenic Pediatric Patients With Immune (Idiopathic) Thrombocytopenia Purpura
Status: COMPLETED
Conditions: Thrombocytopenia in Pediatric Subjects With Immune Idiopathic Thrombocytopenic Purpura ITP
Interventions: BIOLOGICAL: Romiplostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of IrisFIT™ Patent Foramen Ovale Occluders
Status: WITHDRAWN
Conditions: Patent Foramen Ovale|Cryptogenic Stroke
Interventions: DEVICE: Iris FIT™ PFO closure system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of the Low Dose Chidamide in the Management of Refractory ITP
Status: UNKNOWN
Conditions: Thrombocytopenia
Interventions: DRUG: Chidamide|DRUG: Chidamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of Pagoclone for Adults With Stuttering
Status: COMPLETED
Conditions: Stuttering
Interventions: DRUG: pagoclone|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Usage of Procalcitonin to Reduce Antibiotics Duration in VAP in Neurosurgical ICU
Status: NOT_YET_RECRUITING
Conditions: Antibiotic Side Effect
Interventions: DIAGNOSTIC_TEST: Shorten antibiotics duration based on procalcitonin test levels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Three Daily Disposable Contact Lenses
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: Lens 1 (etafilcon A)|DEVICE: Lens 2 (nelfilcon A)|DEVICE: Lens 3 (nesofilcon A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Adults With Moderate to Severe Endometriosis-Associated Pain
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: Elagolix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Merimepodib in Combination With Remdesivir in Adult Patients With Advanced COVID-19
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Merimepodib|DRUG: Matching Placebo|DRUG: Remdesivir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effect of Extracellular Calcium on Oxytocin-induced Human Myometrial Contractility In-vitro
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Oxytocin|DRUG: Calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Complex, Partnered Martial Arts-based Intervention on Cognitive Function
Status: TERMINATED
Conditions: Cognitive Change|Processing, Visual Spatial|Inhibition (Psychology)|Working Memory
Interventions: BEHAVIORAL: HUBOD|BEHAVIORAL: Active Comparator|BEHAVIORAL: Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ESPB Versus INB With PCIA in Video-assisted Thoracic Surgery
Status: COMPLETED
Conditions: Lung Diseases
Interventions: DRUG: Intercostal Nerve Block with PCIA|DRUG: Erector Spinae Plane Block (ESPB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Switching From Sitagliptin to Liraglutide in Subjects With Type 2 Diabetes Not Achieving Adequate Glycaemic Control on Sitagliptin and Metformin
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: sitagliptin|DRUG: placebo|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Research Study to See How Switching From a Daily Basal Insulin to a New Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine in Adults With Type 2 Diabetes
Status: RECRUITING
Conditions: Diabetes, Type 2
Interventions: DRUG: Insulin icodec|DRUG: Insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of DNA Fragmentation in Sperm on Pregnancy Outcome After Intra-uterine Insemination in a Spontaneous Cycle
Status: COMPLETED
Conditions: Infertility Unexplained|Infertility, Male|DNA Damage
Interventions: DIAGNOSTIC_TEST: DNA fragmentation by TUNEL assay
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Influence of Electroacupuncture on Postoperative Agitation of Pediatrics Undergoing Sevoflurane General Anesthesia
Status: ACTIVE_NOT_RECRUITING
Conditions: General Anesthetics Toxicity|Postoperative Cognitive Dysfunction|Electroacupuncture
Interventions: OTHER: electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Efficacy of Empasiprubart in Adults with Dermatomyositis
Status: RECRUITING
Conditions: Dermatomyositis|Myositis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a Stationary Cycling Intervention for Children With Spastic Diplegic Cerebral Palsy
Status: COMPLETED
Conditions: Spastic Diplegic Cerebral Palsy
Interventions: OTHER: Stationary Cycling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Observational Trial to Evaluate Quality of Life After Definitive Chemoradiation in Patients With Anal Cancer (LANACARE)
Status: RECRUITING
Conditions: Anal Cancer|Quality of Life|Chemoradiation
Interventions: OTHER: EORTC QLQ C30|OTHER: EORTC QLQ CR29
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Selenium Supplementation on Inflammatory,Oxidative and Nutritional Markers in Hemodialysis Patients
Status: COMPLETED
Conditions: Inflammation|Malnutrition|Complication of Hemodialysis
Interventions: DIETARY_SUPPLEMENT: selenium yeast|OTHER: placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determinants of the Progression and Outcome of Mitral Regurgitation
Status: UNKNOWN
Conditions: Mitral Valve Insufficiency
Interventions: OTHER: Blood biomarkers|GENETIC: DNA collection|OTHER: Echocardiography|OTHER: Cardiopulmonary exercise testing|OTHER: Magnetic resonance imaging (MRI)|OTHER: Exercise stress doppler echocardiography|OTHER: Holter ECG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate Safety and Dosimetry of [18F]GEH121224 in Patients With Locally Advanced or Metastatic Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: GEH121224 (18F) Injection|DIAGNOSTIC_TEST: Dynamic and Static - PET/CT Scan|DIAGNOSTIC_TEST: Static - PET/CT Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Erlotinib Hydrochloride and Cabozantinib-s-Malate Alone or in Combination as Second or Third Line Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Lung Non-Small Cell Carcinoma|Stage IV Lung Non-Small Cell Cancer AJCC v7
Interventions: DRUG: Cabozantinib S-malate|DRUG: Erlotinib Hydrochloride|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of 99mTc-MIP-1404 and 99mTc-MIP-1405 in Patients With Metastatic Prostate Adenocarcinoma and Healthy Volunteers
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: RADIATION: 99mTc MIP 1404|RADIATION: 99mTc MIP 1405
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Hormone Therapy Plus Chemotherapy in Treating Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: bicalutamide|DRUG: docetaxel|DRUG: doxorubicin hydrochloride|DRUG: estramustine phosphate sodium|DRUG: flutamide|DRUG: ketoconazole|DRUG: paclitaxel|DRUG: releasing hormone agonist therapy|DRUG: vinblastine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addition of Gonadotropin Releasing Hormone Agonist to Luteal Phase Support
Status: COMPLETED
Conditions: Female Infertility
Interventions: DRUG: gonadotropin releasing hormone-agonist|DRUG: Progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Pharmacokinetics of Gammaplex in Primary Immunodeficiency Diseases.
Status: COMPLETED
Conditions: Primary Immunodeficiency|Common Variable Hypogammaglobulinemia|X-linked Hypogammaglobulinemia|Hypogammaglobulinemia|Immunodeficiency With Hyper-IgM|Wiskott-Aldrich Syndrome
Interventions: BIOLOGICAL: Gammaplex (Intravenous immunoglobulin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Different Head Positions on Occlusal Contacts During Digital Interocclusal Bite Registration
Status: COMPLETED
Conditions: Occlusion
Interventions: OTHER: Digital Interocclusal Record In Different Head Positions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC