pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of an 8-day Advanced Meditation, Samyama on Physical, Psychological and Spiritual Wellbeing ,and Associated Neural Mechanisms
Status: COMPLETED
Conditions: Mental Health Wellness 1|Happiness|Depression|Consciousness, Level Altered|Ecstasy|Dietary Habits|Stress|Inflammatory Bowel Diseases
Interventions: OTHER: Part A1: Survey|OTHER: Part A2: Sample collection|OTHER: Part B:
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Randomized Controlled Trials of Electro-acupuncture Effects on Perioperative Anxiety in Patients Treated With PCI
Status: UNKNOWN
Conditions: Percutaneous Coronary Intervention
Interventions: OTHER: acupuncture|OTHER: Psychotherapy|OTHER: blank control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: ARIEL4: A Study of Rucaparib Versus Chemotherapy BRCA Mutant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Patients
Status: COMPLETED
Conditions: Ovarian Cancer|Epithelial Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Cancer
Interventions: DRUG: Chemotherapy|DRUG: Rucaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Decitabine in Combination With Sequential Rapamycin or Ribavirin in High Risk AML Patients
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia
Interventions: DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The CAT Study: Atamestane Plus Toremifene Versus Letrozole in Advanced Breast Cancer
Status: TERMINATED
Conditions: Breast Neoplasms|Neoplasms, Hormone-Dependent
Interventions: DRUG: Atamestane|DRUG: Toremifene|DRUG: Letrozole|DRUG: Aromatase inhibition|DRUG: Estrogen receptor blocker|PROCEDURE: Hormone therapy|PROCEDURE: Endocrine therapy|PROCEDURE: Antiestrogen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: StableEyes With Active Neurofeedback
Status: RECRUITING
Conditions: Vestibular Disorder|Vestibular Schwannoma|Space Motion Sickness|Motion Sickness
Interventions: BEHAVIORAL: Traditional Therapy|DEVICE: SWAN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid Use After Thyroid and Parathyroid Surgeries
Status: COMPLETED
Conditions: Thyroidectomy|Parathyroidectomy|Opioid Use|Pain, Postoperative
Interventions: OTHER: Quality improvement bundle
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: SI-B001 as a Single Agent or in Combination With Chemotherapy in the Treatment of Digestive System Malignancies
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: SI-B001|DRUG: Irinotecan|DRUG: FOLFIRI Protocol|DRUG: FOLFOX Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decitabine Combined With Oxaliplatin in Patients With Advanced Renal Cell Carcinoma
Status: UNKNOWN
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: Decitabine; Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety of RTx-015 Injection in Retinitis Pigmentosa Patients (ENVISION)
Status: RECRUITING
Conditions: Retinitis Pigmentosa
Interventions: GENETIC: RTx-015
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing an Intervention in Irritative Contact Dermatitis
Status: RECRUITING
Conditions: Contact Dermatitis|Contact Dermatitis Irritant
Interventions: OTHER: Emollient cream treatment|OTHER: no treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Port Will be Flushed Every 3 Months Instead of Every 4-6 Wks, as Recommended by Port Manufacturer.
Status: COMPLETED
Conditions: Complication of Catheter
Interventions: OTHER: Reduced port-flush schedule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cyclophosphamide and Busulfan Followed by Donor Stem Cell Transplant in Treating Patients With Myelofibrosis, Acute Myeloid Leukemia, or Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Childhood Acute Myeloid Leukemia in Remission|Childhood Myelodysplastic Syndromes|de Novo Myelodysplastic Syndromes|Essential Thrombocythemia|Myelodysplastic Syndrome With Isolated Del(5q)|Polycythemia Vera|Previously Treated Myelodysplastic Syndromes|Primary Myelofibrosis|Recurrent Adult Acute Myeloid Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Secondary Myelodysplastic Syndromes|Secondary Myelofibrosis|Untreated Adult Acute Myeloid Leukemia|Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies
Interventions: DRUG: cyclophosphamide|DRUG: busulfan|DRUG: tacrolimus|DRUG: methotrexate|GENETIC: cytogenetic analysis|OTHER: flow cytometry|OTHER: pharmacological study|OTHER: pharmacogenomic studies|PROCEDURE: peripheral blood stem cell transplantation|PROCEDURE: allogeneic hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of SHJ002 Sterile Ophthalmic Solution in Pediatric Subjects
Status: COMPLETED
Conditions: Myopia
Interventions: DRUG: SHJ - Low concentration|DRUG: SHJ - Mid concentration|DRUG: SHJ - High concentration|DRUG: SHJ - Maximum tolerated
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MedSupport Intervention to Identify and Address Barriers to Pediatric Medication Adherence
Status: NOT_YET_RECRUITING
Conditions: Acute Lymphoblastic Leukemia
Interventions: OTHER: Best Practice|PROCEDURE: Biospecimen Collection|OTHER: Electronic Health Record Review|OTHER: Interview|OTHER: Medical Device Usage and Evaluation|OTHER: Medical Device Usage and Evaluation|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 3-Week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07008)
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Asenapine|DRUG: Olanzapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gene Transfer for Severe Combined Immunodeficiency, X-linked (SCID-X1) Using a Self-inactivating (SIN) Gammaretroviral Vector
Status: COMPLETED
Conditions: Severe Combined Immunodeficiency
Interventions: BIOLOGICAL: Gene transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Hemorrhage and Functional Outcome in Stroke Patients With CAA Features on Pre-thrombolysis MRI Treated With Intravenous Thrombolysis (Thrombolysis in CAA) ( Thromb in CAA )
Status: COMPLETED
Conditions: Hemorrhage|Cerebral Amyloid Angiopathy|Stroke
Interventions: OTHER: None, pure observational study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cholecalciferol Supplementation for Sepsis in the ICU
Status: COMPLETED
Conditions: Hypovitaminosis D
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Gather Information About the Progress and Outcomes of Pregnancy in Women Using Various Vitamin Support Plans Before and During Pregnancy
Status: ACTIVE_NOT_RECRUITING
Conditions: Prevention of Vitamin Deficiency During and/or Before Pregnancy
Interventions: DIETARY_SUPPLEMENT: Multivitamins (Elevit, BAY987808)|DIETARY_SUPPLEMENT: Multivitamins (Elevit, BAY2906300)|DRUG: Multivitamins (Elevit, BAY987386)|DIETARY_SUPPLEMENT: Folic acid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rifaximin Soluble Solid Dispersion (SSD) Tablets Plus Lactulose for the Treatment of Overt Hepatic Encephalopathy (OHE)
Status: COMPLETED
Conditions: Overt Hepatic Encephalopathy
Interventions: DRUG: 40 mg Rifaximin SSD once daily|DRUG: 40 mg Rifaximin SSD twice daily|DRUG: 80 mg Rifaximin SSD once daily|DRUG: 80 mg Rifaximin SSD twice daily|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Amantadine Therapy for Cognitive Impairment in Long COVID
Status: RECRUITING
Conditions: Long COVID|Post-COVID19 Condition|Post-Acute COVID19 Syndrome
Interventions: DRUG: Amantadine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treating Patients With Metastatic Prostate Cancer Not Responding to Hormone and Chemotherapy
Status: COMPLETED
Conditions: Adenocarcinoma of the Prostate|Recurrent Prostate Cancer|Stage IV Prostate Cancer
Interventions: DRUG: mitoxantrone hydrochloride|DRUG: ixabepilone|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide With or Without Rituximab in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: rituximab|DRUG: lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Analgesic Duration of Dexmedetomidine Compared to Dexamethasone as Adjuncts to Single Shot Interscalene Block
Status: COMPLETED
Conditions: Opioid Use, Unspecified
Interventions: DRUG: Ropivacaine|DRUG: Dexmedetomidine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Blood Concentrations and Actions of Recombinant Human Parathyroid Hormone (rhPTH [1-84]) When Given Once and Twice Daily to Participants With Hypoparathyroidism
Status: COMPLETED
Conditions: Hypoparathyroidism
Interventions: DRUG: 25mcg rhPTH(1-84)|DRUG: 50mcg rhPTH(1-84)|DRUG: 100mcg rhPTH(1-84)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Motor-Related Beta-Activity in Relation to Naturalistic Movement in Healthy Adult Subjects
Status: RECRUITING
Conditions: Motor Cortex|Primary Motor Cortex
Interventions: OTHER: Reach and grasp tasks in healthy participants using MEG technique (Experiment 1)|OTHER: Reach and grasp tasks in healthy participants using EEG technique (Experiment 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Listening to Binaural Beats on Anxiety and Pain Scores in Males Undergoing Cystoscopy and Stent Removal
Status: COMPLETED
Conditions: Anxiety|Cystoscopy|Pain
Interventions: OTHER: Listening to Pure Binaural Beats|OTHER: Listening to classical music|OTHER: No audio only headphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Use of a Smartphone to Assess Balance and Provide Intervention to Older Adults at Home
Status: COMPLETED
Conditions: Fall
Interventions: DEVICE: Balance Exercises - Smartphone Delivery|OTHER: Balance Exercises - Traditional Paper Delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Combination Chemotherapy in Treating Young Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Childhood Central Nervous System Choriocarcinoma|Childhood Central Nervous System Embryonal Tumor|Childhood Central Nervous System Germ Cell Tumor|Childhood Central Nervous System Germinoma|Childhood Central Nervous System Mixed Germ Cell Tumor|Childhood Central Nervous System Teratoma|Childhood Central Nervous System Yolk Sac Tumor|Recurrent Childhood Brain Stem Glioma|Recurrent Childhood Central Nervous System Embryonal Tumor|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: oxaliplatin|DRUG: fluorouracil|DRUG: leucovorin calcium|OTHER: pharmacological study|PROCEDURE: positron emission tomography|PROCEDURE: computed tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 12-week Post-marketing, Observational Study to Confirm the Safety and Efficacy of Zetia Alone or in Combination With Other Lipid-lowering Drugs in Japanese Subjects With Hypercholesterolemia (Study P05244)
Status: COMPLETED
Conditions: Hypercholesterolemia|Familial Hypercholesterolemia|Homozygous Sitosterolemia
Interventions: DRUG: Ezetimibe|DRUG: Ezetimibe + other lipid-lowering medication(s)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessing the Effects of Alfacalcidol Intake on Expression of Involed Gene in Metabolism in Obese Subjects
Status: UNKNOWN
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Alfacalcidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Enhancing Self Regulation Among Smokers
Status: COMPLETED
Conditions: Smoking Cessation|Smoking, Cigarette|Nicotine Dependence
Interventions: DRUG: sirolimus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel Based Anthracycline Free Adjuvant Treatment Evaluation, as Well as Life Style Intervention
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Drug-based intervention|BEHAVIORAL: Lifestyle-based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Long-Term Safety and Efficacy of Evinacumab in Patients With Homozygous Familial Hypercholesterolemia
Status: COMPLETED
Conditions: Homozygous Familial Hypercholesterolemia
Interventions: DRUG: evinacumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Reduction in Glucose Stimulated Insulin Secretion Induced by Cytokines May be Prevented by Copper Addition - Studies in Diabetic Patients
Status: UNKNOWN
Conditions: Hyperglycemia|Diabetes
Interventions: DIETARY_SUPPLEMENT: copper sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Clinical Investigation Evaluating Three New 1-piece Ostomy Products
Status: COMPLETED
Conditions: Ileostomy - Stoma
Interventions: DEVICE: Ostomy device 1|DEVICE: Ostomy device 2|DEVICE: Ostomy device 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dosimetry and Safety Phase 1 Study With 68Ga-PSMA-11 Sterile Cold Kit
Status: COMPLETED
Conditions: Prostatic Neoplasm
Interventions: COMBINATION_PRODUCT: Gallium-68 PSMA-11 prepared using PSMA-11 Sterile Cold Kit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Eribulin Mesylate Phase IV Clinical Trial in Korean Patients With Metastatic or Locally Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms|Breast Cancer
Interventions: DRUG: Eribulin mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of 4-Hydroxytamoxifen Gel on Breast Density, Salivary Sex Steroids, and Quality of Life in Premenopausal Women
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: 4-hydroxytamoxifen|PROCEDURE: breast imaging study|PROCEDURE: radiomammography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: SCREENING
Clinical trial: Darbepoetin Alfa With or Without Intravenous (IV) Iron
Status: COMPLETED
Conditions: Anemia|Non-Myeloid Malignancies
Interventions: DRUG: darbepoetin alfa|DRUG: IV iron dextran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mobile Phone Daily Alarm To Improve Compliance Of Intranasal Corticosteroid Among Allergic Rhinitis Patients.
Status: UNKNOWN
Conditions: Rhinitis, Allergic|Compliance, Medication
Interventions: OTHER: Mobile phone alarm reminder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Lumasiran in Hyperoxalaemic Patients on Haemodialysis
Status: RECRUITING
Conditions: Haemodialysis|Chronic Kidney Disease Requiring Chronic Dialysis|Cardiovascular Disease|Cardiovascular Risk Factor|Hyperoxalemia
Interventions: DRUG: Lumasiran|DRUG: 0.9% Sodium Chloride (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tissue Flossing and Lower Limb Neuromuscular Function
Status: COMPLETED
Conditions: Physical Performance|Neuromuscular Function|Tissue Flossing|Ischemic Preconditioning
Interventions: PROCEDURE: Tissue flossing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Pain, Tolerability, Safety, and Usability of a Single Self-administered Etrolizumab by Auto-injector in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Etrolizumab|DEVICE: Prefilled Auto-injector (Rotaject)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Study of ORIC-533 in Relapsed or Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: DRUG: ORIC-533
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Mitochondrial Toxicity of Tenofovir Alafenamide (TAF) vs. Tenofovir Disoproxil Fumarate (TDF)
Status: COMPLETED
Conditions: HIV/AIDS|Antiviral Toxicity|Antiviral Drug Adverse Reaction|Mitochondrial Alteration
Interventions: DRUG: Switch to E/C/FTC/TAF daily
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Biological Signatures Resulting From Occupational Exposure to Complex Mixtures of PAHs
Status: RECRUITING
Conditions: Metabolic Disturbance|Protein Deficiency|Genotoxicity
Interventions: BIOLOGICAL: Characterization of early biological effects following exposure to PAHs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Comparing Tigecycline to Imipenem/Cilastatin in Complicated Intra-Abdominal Infections in Hospitalized Subjects
Status: COMPLETED
Conditions: Gram-Positive Bacterial Infections|Cross Infection
Interventions: DRUG: Tigecycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Roflumilast Plus Antipsychotics Proof of Mechanism Study in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Roflumilast|DRUG: Placebo|DRUG: Second generation antipsychotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Group Residential Retreat on Cancer Outcomes
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Residential Program|BEHAVIORAL: Questionnaires|DEVICE: Electroencephalogram (EEG)|OTHER: Saliva Testing|BEHAVIORAL: Study Diary plus Actigraph
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: National Vaccine Adverse Event Reporting Survey and Etiology
Status: UNKNOWN
Conditions: COVID-19|Vaccine Adverse Reaction|Vaccine Reaction|Vaccine or Biological Substance, Unspecified Causing Adverse Effects in Therapeutic Use|Corona Virus Infection|Blood Clot|Thrombocytopenia|Neuritis|Vasculitis|Influenza|Guillain-Barré|GWAS|Genetic Sequencing
Interventions: BIOLOGICAL: vaccinated
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized Comparison of Laparoscopic Myotomy and Pneumatic Dilatation for Achalasia
Status: UNKNOWN
Conditions: Esophageal Achalasia
Interventions: PROCEDURE: pneumatic dilatation|PROCEDURE: laparoscopic myotomy with partial fundoplication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epidemiological Study on the Vaccination Coverage of the Population Aged 75 Years and Over in Picardy. According to the Study of 200 Patients Followed by General Practitioners of the Somme in 2016.
Status: COMPLETED
Conditions: Vaccination|Elderly
Interventions: OTHER: Analysis records of patients over 75 years of age
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MagnetOs™ Granules vs. Autograft in Instrumented Posterolateral Spinal Fusion
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Fusion
Interventions: PROCEDURE: Instrumented posterolateral spinal fusion|DEVICE: MagnetOs™ Granules|PROCEDURE: Autologous bone graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Volume Expansion With Albumin vs. Crystalloid and Expiratory Lung Impedance
Status: UNKNOWN
Conditions: Circulatory Failure
Interventions: PROCEDURE: Fluid loading with Albumin|PROCEDURE: Fluid loading with Ringer Lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarkers, Genomics, Physiology in Critically Ill and ECMO Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Respiratory Distress Syndrome|Cardiac Failure|Extracorporeal Membrane Oxygenation Complication|Respiratory Failure|Renal Failure|Critical Illness|Pulmonary Disease
Interventions: DEVICE: Ventilator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sucrose Analgesia for the Reduction of Pain During Retinopathy of Prematurity Screening
Status: COMPLETED
Conditions: Retinopathy of Prematurity
Interventions: OTHER: Sucrose|OTHER: Sterile water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study of NBP606 in Healthy Toddlers
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: NBP606|BIOLOGICAL: Prevnar13
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Carboplatin Plus Pemetrexed Plus Atezolizumab Plus Bevacizumab in Chemotherapy and Immunotherapy-naïve Patients With Stage IV Non-squamous Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: NSCLC Stage IV|NSCLC, Recurrent
Interventions: DRUG: Carboplatin|DRUG: Pemetrexed|DRUG: Atezolizumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest of the Injection of Morphine, in Addition to a Local Anesthetic When Performing a Combined Spinal-epidural for Labor Analgesia
Status: COMPLETED
Conditions: Pregnant Women
Interventions: DRUG: experimental group : sequential combined spinal epidural with local anesthetic injection (chirocaine) associated with morphine (sufentanil).|DRUG: control group : sequential combined spinal epidural with local anesthetic injection (chirocaine) alone.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Esketamine on Postoperative Pain Relief in Patients Undergoing Laparoscopic Surgery
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: DRUG: saline|DRUG: Esketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: SGLT-2 Inhibitor Empagliflozin Effects on Appetite and Weight Regulation.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Empagliflozin|BEHAVIORAL: Diet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Venetoclax and Vincristine Liposomal in Treating Patients With Relapsed or Refractory T-cell or B-cell Acute Lymphoblastic Leukemia
Status: RECRUITING
Conditions: B Acute Lymphoblastic Leukemia|Lymphoblasts 5 Percent or More of Bone Marrow Nucleated Cells|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Lymphoblastic Leukemia|Refractory Acute Lymphoblastic Leukemia|T Acute Lymphoblastic Leukemia
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Venetoclax|DRUG: Vincristine Liposomal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fractional Handpiece With CO2 Laser: Fractional Ablative Laser Treatment of Vulvovaginal Atrophy
Status: UNKNOWN
Conditions: Vulvovaginal Atrophy
Interventions: DEVICE: CO2 Laser Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PACAP38 Induced Headache, Migraine and Flushing in Patients With Migraine
Status: COMPLETED
Conditions: Migraine Without Aura
Interventions: DRUG: Imigran|OTHER: Isotonic Saline|OTHER: Pituitary adenylate cyclase-activating peptide-38
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Statins in Patients With Spontaneous Intracerebral Hemorrhage
Status: COMPLETED
Conditions: Intracerebral Hemorrhage
Interventions: DRUG: Atorvastatin|DRUG: Rosuvastatin|OTHER: No drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Social Media-based Active Self-report on Incidence and Outcomes of Adverse Events in NK/TCL Patients
Status: COMPLETED
Conditions: Extranodal NK-T-Cell Lymphoma, Nasal Type
Interventions: COMBINATION_PRODUCT: L-Asparaginase or or Pegaspargase containing chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Preoperative FFR on Arterial Bypass Graft Functionality
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Disease
Interventions: PROCEDURE: Fractional Flow Reserve (FFR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Breath Stacking Technique Associated With Expiratory Muscle Training in Amyotrophic Lateral Sclerosis Patients
Status: TERMINATED
Conditions: Amyotrophic Lateral Sclerosis|Neuromuscular Diseases
Interventions: DEVICE: Breath Stacking Group|DEVICE: Breath stacking and EMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Milk Products in the Treatment of Hypophosphatemic Rickets
Status: COMPLETED
Conditions: Hypophosphatemic Rickets
Interventions: DIETARY_SUPPLEMENT: Phosphate tablets.|DIETARY_SUPPLEMENT: High cheese intake.|DIETARY_SUPPLEMENT: High milk intake.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted Fluorescence Imaging in AMD
Status: RECRUITING
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: Bevacizumab-IRDye800CW|DRUG: Vedolizumab-IRDye800CW
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Asacol™ 4.8 g/Day (800 mg Tablets) for the Treatment of Active Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Mesalamin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Infusion of Yerba Mate on Oxidative Stress, Physiology, and Performance of Trained Cyclists
Status: COMPLETED
Conditions: Sports Performance|Sports Nutritional Sciences|Endurance Performance
Interventions: OTHER: Yerba mate infusion|OTHER: Carbohydrate meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Traditional Electrosurgery System Versus Low Thermal Tissue Dissection System for Total Mastectomy
Status: UNKNOWN
Conditions: Seroma
Interventions: DEVICE: Low thermal electrosurgery system|DEVICE: Conventional Electrocautery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Synapse 3D With Intravascular Indocyanine Green
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer|Primary Neoplasm
Interventions: DEVICE: Synapse 3D Lung Modelling|DRUG: IC-Green (ICG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Artifact-Free High-Resolution Myocardial Perfusion MRI in Subjects With Abnormal Nuclear Myocardial Perfusion Studies
Status: COMPLETED
Conditions: Coronary Artery Disease|CAD
Interventions: DRUG: regadenoson|DRUG: Optimark®|DEVICE: Myocardial perfusion MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Short-term Effects of Paced Bottle-Feeding on Feeding Interactions
Status: COMPLETED
Conditions: Mother-Infant Interaction|Breastfeeding|Bottle Feeding
Interventions: BEHAVIORAL: Paced Bottle-Feeding Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Bupivacaine After Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: videolaparocholecystectomy|PROCEDURE: videolaparocholecystectomy|PROCEDURE: videolaparocholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Apalutamide With or Without Stereotactic Body Radiation in Treating Castration-Resistant Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Castration Levels of Testosterone|Castration-Resistant Prostate Carcinoma|PSA Progression|Stage IV Prostate Adenocarcinoma AJCC v7
Interventions: DRUG: Apalutamide|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Food on Pharmacokinetics of Total EPA and Total DHA of AZD0585 in Healthy Male Japanese Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD0585
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Bupivacaine Liposome Anterior Serratus Deep Block on Chronic Pain After Breast Cancer Surgery: a Randomized Controlled Study
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer Patients With Chronic Pain After Surgery
Interventions: DRUG: Anterior serratus block group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Vamikibart (RO7200220) in Combination With Ranibizumab in Diabetic Macular Edema
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetic Macular Edema
Interventions: DRUG: Vamikibart|DRUG: Ranibizumab|OTHER: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RFA Plus Carrizumab vs Carrizumab Alone for HCC
Status: RECRUITING
Conditions: Tumor Immunity|Immunosuppression|Radiofrequency Ablation
Interventions: COMBINATION_PRODUCT: radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Converting HR+ Breast Cancer Into an Individualized Vaccine
Status: RECRUITING
Conditions: Breast Cancer
Interventions: RADIATION: Focal Radiation therapy|DRUG: Pembrolizumab (200mg IV for 30 minutes|BIOLOGICAL: CDX-301
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Response to AG-86893 in Patients With Pterygium Hyperemia
Status: COMPLETED
Conditions: Pterygium
Interventions: DRUG: 0.1% AG-86893 Eye Drops|DRUG: 0.3% AG-86893 Eye Drops|DRUG: Vehicle Eye Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MRP and PNF Effect on Upper Limb Motor Performance and Quality of Life in Sub-acute Stroke
Status: COMPLETED
Conditions: Stroke, Ischemic
Interventions: OTHER: Motor Relearning Program|OTHER: Proprioceptive Neuromuscular Facilitation|OTHER: Conventional Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multicentric Clinical Study on Isatis TF Trifocal Intraocular Lens
Status: RECRUITING
Conditions: Cataract|Lens Opacities
Interventions: DEVICE: Implantation of trifocal IOL, Isatis TF (device under investigation)|DEVICE: Implantation of monofocal IOL, Isatis (control device)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2b Study of GSK4532990 in Adults With NASH
Status: RECRUITING
Conditions: Nonalcoholic Fatty Liver Disease
Interventions: DRUG: GSK4532990|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BioDFence® G3 For Full Nerve-Sparing Robotic-Assisted Radical Prostatectomy
Status: WITHDRAWN
Conditions: Prostate Cancer|Prostatectomy|Erectile Dysfunction Following Radical Prostatectomy|Incontinence, Urinary
Interventions: BIOLOGICAL: BioDFence G3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Investigation on Safety, Tolerability and Pharmacokinetics of Single Doses of NNC0174-0833 in Normal Weight, Overweight to Obese But Otherwise Healthy Male Subjects
Status: COMPLETED
Conditions: Metabolism and Nutrition Disorder|Obesity
Interventions: DRUG: NNC0174-0833|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of N-acetyl Cysteine During Primary Percutaneous Coronary Intervention
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute ST Segment Elevation Myocardial Infarction
Interventions: DRUG: NAC|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Use of Microneedles to Expedite Treatment Time in Photodynamic Therapy
Status: COMPLETED
Conditions: Keratosis, Actinic
Interventions: DEVICE: Microneedle Roller|DRUG: Aminolevulinic Acid|RADIATION: Blue Light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Palbociclib in Metastatic Breast Cancer: Gene Polymorphism-based Study in Egyptian Patients.
Status: NOT_YET_RECRUITING
Conditions: Hormone-receptor-positive Breast Cancer|Human Epidermal Growth Factor 2 Negative Carcinoma of Breast|Metastatic Breast Cancer
Interventions: DRUG: Palbociclib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Performance of the I-gel and the Laryngeal Tube Suction Disposable by Novice Intubators"
Status: UNKNOWN
Conditions: Anesthesia
Interventions: DEVICE: i-gel Supraglottic insertion|DEVICE: Laryngeal Tube Suction Disposable Supraglottic insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Stiffness and Pressure Applied on the Lower Leg by a New Compression Bandage on Healthy Subjects
Status: UNKNOWN
Conditions: Healthy Subjects
Interventions: DEVICE: URGOBD001|DEVICE: URGOBD001 associated with wading
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Radicle Rest 24: A Study of Health and Wellness Products on Sleep and Related Health Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Sleep|Sleep Disturbance|Sleep Disorder
Interventions: DIETARY_SUPPLEMENT: Radicle Rest Placebo Control Form 1|DIETARY_SUPPLEMENT: Radicle Rest Active Study Product 1.1 Usage|DIETARY_SUPPLEMENT: Radicle Rest Placebo Control Form 2|DIETARY_SUPPLEMENT: Radicle Rest Active Study Product 2.1 Usage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Randomized Controlled Study of Plasmaknife Tonsillectomy Versus Monopolar Tonsillectomy
Status: UNKNOWN
Conditions: Obstructive Tonsillar Hypertrophy|Tonsillitis
Interventions: DEVICE: Plasmaknife|DEVICE: Monopolar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study on Ivermectin and Hydroxychloroquine on the COVID19 Patients in Bangladesh
Status: COMPLETED
Conditions: Ivermectin|Hydroxychloroquine|COVID19
Interventions: DRUG: Ivermectin + Doxycycline|DRUG: Hydroxychloroquine + Azithromycin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Microbiome, Bile Acids, and Notch in Barrett's Esophagus (BE)
Status: RECRUITING
Conditions: Barrett Esophagus|Esophageal Adenocarcinoma
Interventions: OTHER: Sample Collection|OTHER: Endoscopy results|OTHER: Dietary questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of RSV/Flu-01E Vaccine for the Prevention of RSV Infection in Volunteers Aged 18 to 59 Years and Over 60 Years
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: RSV/Flu-01E low dose|BIOLOGICAL: RSV/Flu-01E high dose|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Family-supported Smoking Cessation for Chronically Ill Veterans
Status: COMPLETED
Conditions: Chronic Disease|Neoplasm|Cardiovascular Disease|Pulmonary Disease, Chronic Obstructive|Diabetes Mellitus|Hypertension
Interventions: BEHAVIORAL: Family-supported|BEHAVIORAL: Standard Telephone counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/KEYNOTE-667)
Status: ACTIVE_NOT_RECRUITING
Conditions: Hodgkin Lymphoma
Interventions: BIOLOGICAL: pembrolizumab|DRUG: doxorubicin|DRUG: vinblastine|DRUG: dacarbazine|DRUG: cyclophosphamide|DRUG: vincristine|DRUG: prednisone/prednisolone|DRUG: bleomycin|DRUG: etoposide|RADIATION: Radiotherapy (RT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Complications Following Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Arthroplasty, Replacement, Knee
Interventions: OTHER: General Anesthesia|OTHER: Regional Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of OB-002 in Patients With Refractory Metastatic Cancer
Status: NOT_YET_RECRUITING
Conditions: Metastatic Cancer|Metastatic Colorectal Cancer|Metastatic Pancreatic Cancer|Metastatic Gastric Cancer|Metastatic Breast Cancer|Metastatic Urothelial Carcinoma
Interventions: DRUG: OB-002
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drain After Elective Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Cholelithiasis
Interventions: PROCEDURE: no drain|PROCEDURE: drain positioned|PROCEDURE: drain not positioned
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of 59% Hioxifilcon A vs. Marketed Hydrogel Contact Lenses in Habitual Hydrogel Wearers
Status: COMPLETED
Conditions: Refractive Error - Myopia Bilateral
Interventions: DEVICE: Hioxifilcon A standard hydrogel contact lens with Hyaluronic Acid (HA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Randomized Study of Paromomycin (Aminosidine) vs Streptomycin for Uncomplicated Pulmonary Tuberculosis
Status: COMPLETED
Conditions: Tuberculosis, Pulmonary
Interventions: DRUG: paromomycin|DRUG: streptomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Left Atrial Appendage Closure vs. Novel Anticoagulation Agents in Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: NOAC|DEVICE: Left atrial appendage closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies
Status: RECRUITING
Conditions: Solid Tumor, Adult|Triple Negative Breast Cancer|Colorectal Cancer|Hepatocellular Carcinoma|Osteosarcoma|Epithelial Ovarian Cancer|Gastric Cancer|Non-small Cell Lung Cancer|Malignant Melanoma
Interventions: BIOLOGICAL: CRX100 suspension for infusion|COMBINATION_PRODUCT: Fludarabine|COMBINATION_PRODUCT: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Everolimus in Patients With Advanced Solid Malignancies With TSC1, TSC2, NF1, NF2, or STK11 Mutations
Status: COMPLETED
Conditions: Solid Malignancy|Solid Tumor
Interventions: DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Isopropyl Alcohol for Treatment of Nausea
Status: RECRUITING
Conditions: Vomiting|Nausea|Children, Only
Interventions: OTHER: Inhaled Isopropyl Alcohol|DRUG: Oral Ondansetron|OTHER: Inhaled Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Paediatric VLA2001-321 Study
Status: WITHDRAWN
Conditions: SARS-CoV-2 Infection
Interventions: BIOLOGICAL: VLA2001|DRUG: Active Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION