pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: To Investigate the Effect of Arabinogalactan on the Gut Microbiome in Adults
Status: COMPLETED
Conditions: Gut Microbiota
Interventions: OTHER: arabinogalactan|OTHER: maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The TransCatheter Valve and Vessels Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Stenosis|Multi Vessel Coronary Artery Disease|TAVI|CABG|PCI|Fractional Flow Reserve
Interventions: DEVICE: FFR-guided PCI and TAVI|DEVICE: CABG and SAVR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of an EAA/Whey Composition on Protein Metabolism
Status: COMPLETED
Conditions: Sarcopenia
Interventions: DIETARY_SUPPLEMENT: 6.3 g of EAAs mixture and whey protein isolate|DIETARY_SUPPLEMENT: 12.6 g of EAAs mixture and whey protein isolate|DIETARY_SUPPLEMENT: 12.6 g of whey protein isolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Peroxisome Proliferators Activated Receptor-Gamma (PPAR-γ) Agonists on Certain Biochemical and Inflammatory Markers in Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DRUG: Pioglitazone|DRUG: Telmisartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Biannual Ultrasonography and Annual Unenhanced Magnetic Resonance Imaging for HCC Surveillance
Status: UNKNOWN
Conditions: Cirrhosis|Hepatocellular Carcinoma
Interventions: PROCEDURE: Biannual ultrasonography|PROCEDURE: Annual noncontrast liver MRI|PROCEDURE: Contrast enhanced liver CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effect of Low-load Resistance Training vs. High-intensity Interval Training on Local Muscle Endurance
Status: RECRUITING
Conditions: Hypertrophy|Muscle Strength|High-Intensity Interval Training|Resistance Training
Interventions: BEHAVIORAL: Low Load Resistance training|BEHAVIORAL: Sprint/High Intensity Interval Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: RO4929097 and Letrozole in Treating Post-Menopausal Women With Hormone Receptor-Positive Stage II or Stage III Breast Cancer
Status: TERMINATED
Conditions: Estrogen Receptor-positive Breast Cancer|HER2-negative Breast Cancer|Progesterone Receptor-positive Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer
Interventions: DRUG: letrozole|DRUG: gamma-secretase/Notch signalling pathway inhibitor RO4929097|PROCEDURE: therapeutic conventional surgery|PROCEDURE: breast biopsy|OTHER: diagnostic laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of ACI-7104.056 Vaccination in Patients With Early Stages of Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease|Parkinson Disease 6, Early-Onset
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: ACI-7104.056 at Dose A|BIOLOGICAL: ACI-7104.056 at Dose B (optional)|BIOLOGICAL: ACI-7104.056 at Dose C (optional)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telemedicine To Provide Inflammatory Bowel Disease Outpatient Care
Status: COMPLETED
Conditions: Inflammatory Bowel Disease|Ulcerative Colitis|Crohn's Disease
Interventions: DEVICE: Collaborative Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Short-term Antibiotic Treatment for Unexplained Fever in Solid Cancer Patients With Febrile Neutropenia
Status: WITHDRAWN
Conditions: Febrile Neutropenia
Interventions: OTHER: Early antibiotic discontinuation|OTHER: Usual practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Study of Latuda for the Treatment of Mania in Children and Adolescents 6-17 Years Old
Status: WITHDRAWN
Conditions: Mania|Bipolar I|Bipolar II|Bipolar Spectrum Disorder|Bipolar Disorder
Interventions: DRUG: Latuda (Lurasidone)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Study to Determine the Potential Impact of Parental Attendance at WW on Weight and Behavioural Outcomes in Children: WWChild
Status: TERMINATED
Conditions: Obesity, Childhood
Interventions: BEHAVIORAL: WW
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Tolerability and Absorption of Racemic and R-lipoic Acid in Progressive Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Progressive Multiple Sclerosis|Secondary Progressive Multiple Sclerosis|Primary Progressive Multiple Sclerosis
Interventions: DRUG: Alpha Lipoic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Emapalumab Prevention of CAR-T Cell Associated Toxicities
Status: NOT_YET_RECRUITING
Conditions: Large B-cell Lymphoma|Relapsed Non-Hodgkin Lymphoma|Refractory Non-Hodgkin Lymphoma|Diffuse Large B Cell Lymphoma|Primary Mediastinal Large B-cell Lymphoma|High-grade B-cell Lymphoma|Follicular Lymphoma
Interventions: DRUG: Emapalumab|DRUG: Cyclophosphamide|DRUG: Fludarabine Phosphate|DRUG: Axicabtagene Ciloleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Versus Direct Palpation Radial Artery Catheter Insertion Among Cardiac Anesthesiologists
Status: COMPLETED
Conditions: Time to Insertion of Radial Artery Cannulation
Interventions: DEVICE: Ultrasound-guided Radial Artery Catheter Insertion|DEVICE: Direct Palpation-guided Radial Artery Catheter insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Clinical Impact of the Type of Cardioplegia Used in the Patient Undergoing Major Cardiac Surgery.
Status: NOT_YET_RECRUITING
Conditions: Cardiac Surgery|Cardioplegia|Heart Arrest
Interventions: DRUG: Custodiol Htk Soln|DRUG: Buckberg Cardi-Braun
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: FOLFOX6 Plus Sir-Spheres Microspheres Plus Avastin in Patients With Nonresectable Liver Metastases From Colorectal Carcinoma
Status: WITHDRAWN
Conditions: Colorectal Carcinoma|Liver Metastases
Interventions: DEVICE: SIR-Spheres microspheres|DRUG: FOLFOX6 cycles 1-3|DRUG: FOLFOX6 cycles 4 onwards|DRUG: Bevacizumab cycles 3 onwards
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 24-hour Study of Dorzolamide/Timolol and Latanoprost/Timolol Fixed Combinations
Status: COMPLETED
Conditions: Open-angle Glaucoma
Interventions: DRUG: Drug: dorzolamide/timolol|DRUG: Drug: latanoprost/timolol|DRUG: dorzolamide/timolol and latanoprost|DRUG: placebo (artificial tears)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Project THINK: Trial of a Brief Cognitive Restructuring Intervention
Status: COMPLETED
Conditions: Anxiety|Depression|Stress
Interventions: BEHAVIORAL: Project THINK|BEHAVIORAL: Project SHARE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Opioid Education in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Arthropathy of Knee|Post Operative Pain|Opioid Use|Opioid Abuse|Opioid Misuse
Interventions: OTHER: Opioid education in person|OTHER: Opioid education via video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Hydrocodone Bitartrate (HYD) Extended-Release Tablets on QT /QTc Intervals in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HYD|DRUG: Moxifloxacin|DRUG: Placebo for HYD|DRUG: Placebo for moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: SINGLE PATIENT EXPANDED ACCESS OF A PROSPECTIVE, MULTICENTER CLINICAL TRIAL DESIGNED TO EVALUATE THE SAFETY AND PROBABLE BENEFIT OF THE KERAKLEAR NON-PENETRATING KERATOPROSTHESIS IN SUBJECTS WITH CORNEAL OPACITY WITH POOR PROGNOSIS FOR CORNEAL TRANSPLANT
Status: WITHDRAWN
Conditions: CORNEAL OPACITY WITH POOR PROGNOSIS FOR CORNEAL TRANSPLANT
Interventions: OTHER: Experimental
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dapagliflozin Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion
Status: COMPLETED
Conditions: Metabolic Syndrome X
Interventions: DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Practical Demonstration to Use Nasal Spray and Apply Intranasal Ointment on Epistaxis
Status: COMPLETED
Conditions: Epistaxis
Interventions: PROCEDURE: Health education with practical demonstration of nasal ointment|DRUG: Health Education and practical demonstration of Nasal spray and intranasal ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of Cetuximab on Corrected QT (QTc) Interval Changes in Patients With Advanced Malignancies From Solid Tumors
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of BPZE1 Intranasal Pertussis Vaccine in Healthy School-age Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Bordetella Pertussis, Whooping Cough
Interventions: BIOLOGICAL: BPZE1 pertussis vaccine and placebo|BIOLOGICAL: BPZE1 pertussis vaccine and Boostrix|BIOLOGICAL: Placebo and Boostrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Investigating the Impact of Acceptance and Commitment Therapy on Resiliency in Women Affected by Domestic Violence
Status: COMPLETED
Conditions: Domestic Violence
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Simulation of Adenosine Push Methods for Treatment of SVT Using Agitated Saline Visualized by Ultrasound
Status: COMPLETED
Conditions: Supraventricular Tachycardia
Interventions: OTHER: Agitated saline push
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Perioperative Combination Chemotherapy Versus Chemoradiation for Locally Advanced EGJ Adenocarcinoma
Status: NOT_YET_RECRUITING
Conditions: Esophagogastric Junction Disorder|Neoplasms
Interventions: RADIATION: chemoradiation with weekly 5Fu and oxaliplatin|DRUG: Perioperative mFLOT|DRUG: Perioperative FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Before Surgery and Tissue Sample Collection in Patients With Stage IIA-IIIC Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: Cyclophosphamide|OTHER: Cytology Specimen Collection Procedure|DRUG: Doxorubicin Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IC Plus Low-dose Radiation Plus Cadonilimab in LANPC
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma|Immune Checkpoint Inhibitor|Radiotherapy|Chemotherapy
Interventions: RADIATION: Intensity Modulated Radiation Therapy|DRUG: Chemotherapy|BIOLOGICAL: Immune checkpoint inhibitor|RADIATION: Low-dose radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Periodontal Disease, Inflammation and Acute Coronary Syndromes
Status: COMPLETED
Conditions: Coronary Stenosis|Periodontal Diseases|Acute Coronary Syndrome|Non-ST Elevation Myocardial Infarction|Unstable Angina|Acute Myocardial Infarction|Atherosclerosis|Atheromatous Plaques
Interventions: DIAGNOSTIC_TEST: cardiac imaging tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomized Clinical Trial of Intravitreal Bevacizumab Versus Intravitreal Bevacizumab Combined With Losartan in the Treatment of Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Losartan|DRUG: Intravitreal bevacizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Robotic Versus Open Comparison in the Surgical Treatment of Wide Abdominal Wall Hernias
Status: NOT_YET_RECRUITING
Conditions: Ventral Incisional Hernia
Interventions: PROCEDURE: incisional hernia repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Asses Effectiveness and Treatment Management of Oral Venetoclax Tablets + Subcutaneously Injected Azacitidine in Adult Participants Ineligible for Intensive Chemotherapy With de Novo Acute Myeloid Leukemia (AML) in Italy
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Femoral Micropuncture or Routine Introducer Study
Status: TERMINATED
Conditions: Complications
Interventions: DEVICE: Micropuncture needle set|DEVICE: Standard gauge-18 needle set
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Continuous Saphenous Block Versus Continuous Femoral Block for Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Total Knee Arthroplasty Secondary to Osteoarthritis
Interventions: PROCEDURE: continuous femoral nerve block|PROCEDURE: continuous saphenous nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Use of CGM in Kidney Transplant Recipients
Status: RECRUITING
Conditions: Kidney Transplant; Complications|Diabetes Mellitus, Type 2|Insulin Dependent Diabetes
Interventions: DEVICE: Dexcom G6|DEVICE: Dexcom G6 blinded sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Immunogenicity Study of Therapeutic HSV-2 Vaccine
Status: COMPLETED
Conditions: Genital Herpes Simplex Type 2
Interventions: BIOLOGICAL: GEN-003 with Matrix M-2|BIOLOGICAL: GEN-003|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Toripalimab Combined With Gemcitabine and Cisplatin Treating Resectable Locally Advanced HNSCC
Status: RECRUITING
Conditions: Locally Advanced Head and Neck Squamous Cell Carcinoma|Neoadjuvant Therapy
Interventions: DRUG: PD-1 inhibitor+ Gemcitabine + Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections
Status: COMPLETED
Conditions: Refractory Bone or Joint Infections
Interventions: DRUG: sodium fusidate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Proof of Concept Study to Evaluate the Effects of Tasimelteon and Placebo in Travelers With Jet Lag Disorder
Status: COMPLETED
Conditions: Jet Lag Disorder
Interventions: DRUG: Tasimelteon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects Of Muscle Energy Versus Counter Strain Technique on Pain, Function and Satisfaction Level in Planter Fasciitis
Status: COMPLETED
Conditions: Plantar Fasciitis
Interventions: OTHER: Muscle Energy Technique|OTHER: Counterstrain Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RESET-MG: A Study to Evaluate the Safety and Efficacy of CABA-201 in Participants With Generalized Myasthenia Gravis
Status: RECRUITING
Conditions: Generalized Myasthenia Gravis (gMG)
Interventions: BIOLOGICAL: CABA-201
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone Mesenchymal Stem Cell (BMSC) Transplantation in Liver Cirrhosis Via Portal Vein
Status: UNKNOWN
Conditions: Liver Cirrhosis
Interventions: PROCEDURE: Autologous BMSCs transplantation|DRUG: Conserved therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ-90009530 in Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (r/r B-NHL)
Status: RECRUITING
Conditions: Relapsed or Refractory B Cell Non-Hodgkin Lymphoma
Interventions: DRUG: JNJ-90009530
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome (START)
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Adult
Interventions: BIOLOGICAL: Allogeneic Bone Marrow-Derived Human Mesenchymal Stromal Cells|BIOLOGICAL: Plasma-Lyte A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assess the Absorption, Distribution, Metabolism and Excretion of AZD7325 After Intravenous and Oral Administration
Status: SUSPENDED
Conditions: Absorption|Distribution|Metabolism|Excretion
Interventions: DRUG: AZD7325|DRUG: AZD7325
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Heart Rate Variability and Cognitive Load on Image-Based Virtual Reality Instructional Design in Otolaryngology
Status: COMPLETED
Conditions: Cognitive Function 1, Social|Competence|Heart Rate Fast|Learning, Spatial|Otolaryngologic Disorder
Interventions: OTHER: image-based virtual reality learning|OTHER: video-based learning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Calcipotriol Plus Betamethasone Dipropionate Gel Compared With Tacalcitol Ointment and the Gel Vehicle Alone in Patients With Psoriasis Vulgaris
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: calcipotriol and betamethasone (LEO 80185 gel)|DRUG: LEO 80185 vehicle|DRUG: Tacalcitol ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SOF (Sovaldi®) +RBV for 16 or 24 Weeks and SOF+RBV+Peg-IFN for 12 Weeks in Adults With Genotype 2 or 3 Chronic HCV Infection
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: SOF|DRUG: RBV|DRUG: Peg-IFN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel and Bortezomib in Treating Patients With Metastatic or Unresectable Malignant Solid Tumors
Status: COMPLETED
Conditions: Breast Cancer|Colorectal Cancer|Head and Neck Cancer|Lung Cancer|Melanoma (Skin)|Ovarian Cancer|Pancreatic Cancer|Prostate Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: bortezomib|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet-delivered CBT for Functional Abdominal Pain in Adolescents - a Pilot
Status: COMPLETED
Conditions: Functional Gastrointestinal Disorders|Abdominal Pain|Dyspepsia
Interventions: BEHAVIORAL: Internet-delivered CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Compare the Efficacy and Safety of 1-week Treatment of Intravenous N-acetylcysteine (NAC) 600 mg Twice Daily, Ambroxol Hydrochloride 30 mg Twice Daily and Placebo as Expectorant Therapies in Adult Chinese Patients With Respiratory Tract Diseases and Abnormal Mucus Secretions
Status: COMPLETED
Conditions: Respiratory Tract Diseases|Abnormal Mucus Secretions
Interventions: DRUG: N-acetylcysteine (NAC) 600 mg|DRUG: Ambroxol hydrochloride 30 mg|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of a Telenursing Service on Satisfaction and Health Outcomes of Children With Inflammatory Rheumatic Diseases
Status: COMPLETED
Conditions: Inflammatory Rheumatism
Interventions: BEHAVIORAL: Telenursing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Opiate Free Multimodal Pain Pathway in Elective Foot and Ankle Surgery: A Prospective Study
Status: COMPLETED
Conditions: Bunion of Unspecified Foot|Bunionette of Unspecified Foot|Hammertoe|Ankle Fractures|Achilles Tendon Surgery
Interventions: DRUG: Acetominophen|DRUG: Toradol|DRUG: Meloxicam|DRUG: Cyclobenzaprine|DRUG: Lyrica
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Probiotics in Adults: do They Improve Atopic Dermatitis?
Status: COMPLETED
Conditions: Adult Atopic Dermatitis
Interventions: DIETARY_SUPPLEMENT: probiotics|OTHER: maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PEACE V: Salvage Treatment of OligoRecurrent Nodal Prostate Cancer Metastases
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer|Prostate Cancer Metastatic|Metastatic Cancer|Oligometastatic Cancer
Interventions: RADIATION: whole pelvic radiotherapy|RADIATION: metastasis-directed treatment|PROCEDURE: salvage Lymph Node Dissection|DRUG: androgen deprivation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2b Study of Cetuximab With Platinum-Based Chemo as First Line Treatment of Recurrent or Advanced NSCLC
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Cetuximab|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Immediate Lymphatic Reconstruction Decrease the Risk of Lymphedema After Axillary Lymph Node Dissection
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer Lymphedema
Interventions: PROCEDURE: Axillary Lymph Node Dissection with Immediate Lymphatic Reconstruction|PROCEDURE: Axillary Lymph Node Dissection without Immediate Lymphatic Reconstruction|OTHER: quality-of-life questionnaires|OTHER: measured by arm volume
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma
Status: RECRUITING
Conditions: Ganglioneuroblastoma|Localized Resectable Neuroblastoma|Localized Unresectable Neuroblastoma|Regional Neuroblastoma|Stage 4 Neuroblastoma|Stage 4S Neuroblastoma
Interventions: OTHER: Cytology Specimen Collection Procedure|OTHER: Laboratory Biomarker Analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prevention of Intra-uterine Adhesions Following Laparoscopic and Laparotomic Myomectomy
Status: RECRUITING
Conditions: Myoma
Interventions: DEVICE: Hyalobarrier
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Non-invasive Ventilation in Severe Chronic Obstructive Pulmonary Disease(COPD)
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease|Hypercapnia
Interventions: DEVICE: ventilators designed for non invasive ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Developing a Method Using PET-MR to Improve Staging and Monitoring of Neuroendocrine Tumor
Status: UNKNOWN
Conditions: Neuroendocrine Tumors
Interventions: DIAGNOSTIC_TEST: PET/MR scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sorafenib Tosylate and Chemoembolization in Treating Patients With Unresectable Liver Cancer
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Liver Cancer|Localized Unresectable Liver Cancer
Interventions: DRUG: sorafenib tosylate|DRUG: doxorubicin hydrochloride|DRUG: cisplatin|DRUG: mitomycin C|PROCEDURE: transarterial chemoembolization|PROCEDURE: hepatic artery embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Two Dry Power Inhalers (DPIs) Used for the Application of Mometasone in the Treatment of Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DEVICE: OXIMAX|DEVICE: ASMANEX TWISTHALER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Gut-brain Therapy for Children With Autism
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Functional Gastrointestinal Disorders|Neurodevelopmental Disorders|Anxiety
Interventions: COMBINATION_PRODUCT: Synbiotic|BEHAVIORAL: Gut-directed Hypnotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Effects of Food on the Pharmacokinetics/Pharmacodynamics of CKD-519
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: CKD-519 100mg|DRUG: CKD-519 200mg|DRUG: CKD-519 100mg|DRUG: CKD-519 200mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Auditory Interventions on Anxiety and Agitation in People With Dementia
Status: COMPLETED
Conditions: Mild to Moderate Dementia
Interventions: OTHER: Music and Theta Auditory Beat Stimulation|OTHER: Audiobooks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combined Dry Powder Tobramycin and Nebulized Colistin Inhalation in CF Patients
Status: COMPLETED
Conditions: Cystic Fibrosis With Pulmonary Manifestations
Interventions: DRUG: Tobramycin Powder|DRUG: Colistin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn If the Study Medicine Esomeprazole Changes How the Body Processes the Other Study Medicine Vepdegestrant
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: vepdegestrant|DRUG: esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Non-invasive Evaluation of Myocardial Stiffness by Elastography
Status: COMPLETED
Conditions: Diastolic Heart Failure
Interventions: PROCEDURE: elastography function ShearWave Imaging|PROCEDURE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: An Open Label Dose Titration of Sevelamer Carbonate Tabs 3 Times a Day in Hyperphosphatemic CKD Patients Not On Dialysis
Status: COMPLETED
Conditions: Chronic Kidney Disease|Hyperphosphatemia
Interventions: DRUG: Sevelamer carbonate (Renvela®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Social-environmental, Psychosocial, Behavioral, Clinical and Biological Drivers of Disparities in Liver Disease Progression Among Korean American With Chronic Hepatitis B Infection
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Viral Hepatitis|Hepatitis B Infection
Interventions: OTHER: Interview|PROCEDURE: Biospecimen Collection|OTHER: Electronic Health Record Review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Becoming United in Lifestyle Decisions
Status: RECRUITING
Conditions: Overweight and Obesity
Interventions: BEHAVIORAL: Core Behavioral Weight Loss (BWL) intervention|BEHAVIORAL: Dyadic Action Planning|BEHAVIORAL: Joint Feedback|BEHAVIORAL: Autonomy Support Training|BEHAVIORAL: Home Environment Modifications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Serum Interleukin -21 Level in Patients With Severe Adverse Cutaneous Drug Reaction.
Status: UNKNOWN
Conditions: Adverse Cutaneous Reaction to Alternative Medical Therapy
Interventions: DIAGNOSTIC_TEST: serum interleukin 21|DIAGNOSTIC_TEST: Complete Blood Picture|DIAGNOSTIC_TEST: Liver function test|DIAGNOSTIC_TEST: Random Blood Sugar|DIAGNOSTIC_TEST: Erythrocyte Sedimentation Rate|DIAGNOSTIC_TEST: Kidney function tests
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of HIIT in Tolerance to Exercise of Individuals With HF and Coexisting COPD
Status: SUSPENDED
Conditions: Heart Failure|Chronic Obstructive Pulmonary Disease
Interventions: OTHER: High-intensity interval training|OTHER: Continuous aerobic training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Trial Evaluating Chemotherapy and Immunotherapy for Advanced Nasopharyngeal Carcinoma (NPC) Patients
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma
Interventions: BIOLOGICAL: autologous EBV specific Cytotoxic T cells|DRUG: combination IV gemcitabine and IV carboplatin (AUC2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Azithromycin Plus Chloroquine Versus Sulfadoxine-Pyrimethamine Plus Chloroquine for the Treatment of Uncomplicated Malaria in India
Status: COMPLETED
Conditions: PLASMODIUM FALCIPARUM MALARIA
Interventions: DRUG: Azithromycin/Chloroquine|DRUG: Sulfadoxine-Pyrimethamine/Chloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Sagittal Parameters After Mono Segmental Lumber Fusion: Interbody Versus Postrolateral Fusion
Status: COMPLETED
Conditions: Lumbar Spine Fusion
Interventions: PROCEDURE: posterolateral fusion|PROCEDURE: posterior lumbar interbody fusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Slow-flow After Primary Percutaneous Coronary Intervention With Flow-mediated Hyperemia
Status: COMPLETED
Conditions: Coronary Microvascular Disease|Myocardial Infarction
Interventions: DRUG: Drug-mediated hyperemia|OTHER: Flow-mediated hyperemia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Termination of Pregnancy and Psychiatric Implications
Status: COMPLETED
Conditions: Therapeutic Abortion With Complications|Personality Disorders|Trauma, Psychological|Reproductive Behavior|Post Traumatic Stress Disorder|Depression, Reactive
Interventions: DIAGNOSTIC_TEST: Multiple psychometric questionnaire|PROCEDURE: Clinical psychiatric examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: D-CIK Combined With Chemotherapy for Non-Small Cell Lung Cancer(NSCLC)
Status: UNKNOWN
Conditions: Lung Cancer|Non-small Cell Lung Cancer
Interventions: DRUG: Gemcitabine|DRUG: Cisplatin|BIOLOGICAL: D-CIK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Intervention to Support Clinicians' Firearm Safety Counseling Behaviors
Status: ACTIVE_NOT_RECRUITING
Conditions: Virtual Reality|Simulation Based Medical Education|Firearm Injury
Interventions: BEHAVIORAL: Resident Education And Counseling on Household Firearm Safety|BEHAVIORAL: Modified American Academy of Pediatrics Safer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cyclic Versus Daily Teriparatide on Bone Mass
Status: UNKNOWN
Conditions: Osteoporosis
Interventions: DRUG: Teriparatide|DRUG: Alendronate|DIETARY_SUPPLEMENT: Calcium|DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Estimation of CSF Pressure Using MRI in Patients With Spontaneous Intracranial Hypotension
Status: COMPLETED
Conditions: Intracranial Hypotension
Interventions: DEVICE: MRI algorithm|PROCEDURE: Lumbar puncture|PROCEDURE: Epidural patching
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Forehead Temperature-Regulating Therapy for Insomnia in Adults With Tourette's Disorder
Status: RECRUITING
Conditions: Tourette's Disorder|Insomnia
Interventions: DEVICE: Forehead Temperature-Regulating Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Blinded Comparison Trial of Two Topical Creams to Reduce Thigh Girth and to Smooth Thigh Skin in Women
Status: WITHDRAWN
Conditions: Weight Loss
Interventions: OTHER: Cream A applied to left thigh and Cream B to right thigh|OTHER: Cream B applied to left thigh and Cream A to right thigh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Pilot Study of Abaloparatide + Bevacizumab in Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Myelodysplastic Syndromes|Chronic Myelomonocytic Leukemia
Interventions: DRUG: abaloparatide|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selections of Subjects With Important Changes in Their Cardiac Repolarization Parameters for the Procurement of Skin and Blood Samples
Status: COMPLETED
Conditions: Cardiology: RR / QT
Interventions: DRUG: Erythromycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Herbal Medication to Treat Dry Eye in Peri/ Post-menopausal Women
Status: RECRUITING
Conditions: Dry Eye
Interventions: DRUG: Wei's Qi Ju Gan Lu Formula|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Conservative or Surgical Management of Rockwood Type III to V Acromioclavicular Dislocations
Status: UNKNOWN
Conditions: Acromioclavicular Joint Dislocation|Conservative Versus Surgical Management
Interventions: PROCEDURE: Conservative management|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Oral Cannabis in Chronic Spine Pain
Status: NOT_YET_RECRUITING
Conditions: Back Pain|Neck Pain
Interventions: DRUG: THC/CBD|DRUG: THC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of TQB2868 Plus Platinum-based Chemotherapy With or Without Bevacizumab in the First-line Treatment of Persistent, Recurrent, or Metastatic Cervical Cancer
Status: WITHDRAWN
Conditions: Cervical Cancer
Interventions: DRUG: TQB2868 injection|DRUG: Paclitaxel injection|DRUG: Cisplatin injection|DRUG: Carboplatin injection|DRUG: Bevacizumab injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomised Total Knee Arthroplasty With Attune S+ or NexGen CR
Status: RECRUITING
Conditions: Arthroplasty, Replacement, Knee
Interventions: OTHER: Oxford knee score
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Efficacy and Safety of NAFT-600 in Subjects With Tinea Pedis
Status: COMPLETED
Conditions: Tinea Pedis
Interventions: DRUG: NAFT-600 (naftin 2 % gel)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Remimazolam and Midazolam for Preventing Intraoperative Nausea and Vomiting During Cesarean Section Under Spinal Anesthesia
Status: COMPLETED
Conditions: Pregnancy|Cesarean Section|Spinal Anesthesia
Interventions: DRUG: Remimazolam besylate|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Chemoradiation and Surgery on Cardiopulmonary Fitness and Tumor Neoplastic Phenotype in Gastrointestinal Malignancies
Status: TERMINATED
Conditions: Pathologically Proven Gastrointestinal Malignancy|Plan of Care Must Include Chemoradiation
Interventions: OTHER: Cardiopulmonary Exercise Test (CPET)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of REM-422 in Patients With AML or Higher Risk MDS
Status: RECRUITING
Conditions: Myelodysplastic Syndromes|Higher Risk Myelodysplastic Syndromes|Acute Myeloid Leukemia|Acute Myeloid Leukemia Refractory
Interventions: DRUG: REM-422
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of FOLFOX6, Bevacizumab and Cetuximab in Patients With Colorectal Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Rectum|Mucinous Adenocarcinoma of the Colon|Recurrent Colon Cancer|Recurrent Rectal Cancer|Signet Ring Adenocarcinoma of the Colon|Stage IV Colon Cancer|Stage IV Rectal Cancer
Interventions: BIOLOGICAL: cetuximab|BIOLOGICAL: bevacizumab|DRUG: oxaliplatin|DRUG: leucovorin calcium|DRUG: fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Lidocaine Infusion Reduce Postoperative Pulmonary Complications in Patients Undergoing Minimally Invasive Esophagectomy
Status: NOT_YET_RECRUITING
Conditions: Postoperative Pneumonia|Postoperative Pulmonary Atelectasis|Postoperative Pulmonary Edema
Interventions: DRUG: intravenous lidocaine infusion|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Buprenorphine-Fentanyl Interaction Study
Status: COMPLETED
Conditions: Healthy|Opioid Use
Interventions: DRUG: Buprenorphine Injectable Solution - Part A|DRUG: Placebo - Parts A + B|DRUG: Fentanyl - Part A|DRUG: Ondansetron - Parts A + B|DRUG: Buprenorphine Injectable Solution - Part B|DRUG: Fentanyl - Part B|DRUG: Oxycodone - Part B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study to Evaluate Safety and Performance of PEEK-OPTIMA™ HA Enhanced Interbody Cages in the Lumbar Spine
Status: COMPLETED
Conditions: Degenerative Disc Disease Lumbar|Spondylolisthesis, Grade 1
Interventions: DEVICE: Device: EVOS Lumbar Interbody System (EVOS-HA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Status: RECRUITING
Conditions: Tetraplegia|Spinal Cord Injuries|Amyotrophic Lateral Sclerosis|Brain Stem Infarctions|Locked in Syndrome|Muscular Dystrophy
Interventions: DEVICE: Placement of the BrainGate2 sensor(s) into the motor-related cortex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Atropine and DIMS Lenses in Controlling Myopia in Children
Status: RECRUITING
Conditions: Myopia
Interventions: DRUG: Atropine 0,025%|DEVICE: DIMS Lenses|DEVICE: Monofocal lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melatonin and Risk Of Cardiovascular Events And Malignant Tumors In The Elderly
Status: NOT_YET_RECRUITING
Conditions: Cardiovascular Diseases
Interventions: DIETARY_SUPPLEMENT: Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Management and Outcomes of Anti-thrombotic Medication Use in Thrombocytopenia
Status: UNKNOWN
Conditions: Hematologic Neoplasms|Thrombocytopenia|Anticoagulants|Platelet Aggregation Inhibitors
Interventions: DRUG: Hold|DRUG: Prophylactic dose antithrombotic|DRUG: Change antithrombotic Drug|BIOLOGICAL: Change platelet transfusion threshold|DRUG: Full dose antithrombotics|DEVICE: Mechanical measures|DRUG: Intermediate dose antithrombotic
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Sipuleucel-T With or Without Continuing New Hormonal Agents in Metastatic Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer|Metastatic Prostate Cancer
Interventions: DRUG: Abiraterone|DRUG: Enzalutamide|DRUG: Apalutamide|DRUG: Sipuleucel-T
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Yoga Versus Exercises for Managing OA
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Hatha yoga|OTHER: Aerobic and strengthening exercises|OTHER: General education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Two Telemonitoring Auto-titrating Modalities in OSA Patients
Status: COMPLETED
Conditions: Apnea|Sleep Apnea Syndromes|Sleep Apnea, Obstructive|Sleep Disordered Breathing|Respiration; Sleep Disorder|Respiratory Tract Disease|Sleep Disorders, Intrinsic|Sleep Wake Disorders
Interventions: DEVICE: EZ START Titration|DEVICE: APAP Titration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Pre-seasonal BM32 Dosings on the Induction of a Protective Immune Response
Status: COMPLETED
Conditions: Hypersensitivity
Interventions: BIOLOGICAL: BM32|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3, Randomized, Double Blind, Placebo-Controlled, Multi-Center, Withdrawal Study of MCI-196 in CKD on Dialysis With Hyperphosphatemia
Status: COMPLETED
Conditions: Chronic Kidney Disease|Dialysis|Hyperphosphatemia
Interventions: DRUG: MCI-196|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT