pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of the Safety and Efficacy of Prime Editing (PM359) in Participants With p47phox Autosomal Recessive Chronic Granulomatous Disease (CGD )
Status: NOT_YET_RECRUITING
Conditions: Chronic Granulomatous Disease|Granulomatous Disease, Chronic
Interventions: BIOLOGICAL: PM359
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Double Dose of Photobiomodulaton Therapy on Orthodonthic Pain Caused by Elastomeric Separators
Status: COMPLETED
Conditions: Pain Relief Caused by Placing Orthodontic Separators
Interventions: DEVICE: Low level laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carnosine Loading and Periodized Training in MS and HC
Status: COMPLETED
Conditions: Multiple Sclerosis|Exercise Therapy|Dietary Supplement
Interventions: DIETARY_SUPPLEMENT: Beta-alanine supplementation|OTHER: Exercise intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparative Study Between (FC-SEMS) and (PC-SEMS) in the Palliation of Dysphagia Due to Malignant Neoplasm of Esophagus.
Status: RECRUITING
Conditions: Esophageal Neoplasms|Dysphagia
Interventions: DEVICE: Fully Covered Esophageal Prosthesis (FC-SEMS)|DEVICE: Partially Covered Esophageal Prosthesis (PC-SEMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: "Escola em Ação" (School in Action)
Status: COMPLETED
Conditions: Physical Activity|Eating Behavior|Sedentary Lifestyle|Adolescent Behavior
Interventions: BEHAVIORAL: Training|BEHAVIORAL: Individual level|BEHAVIORAL: Organizational level
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: LLLT Combined With CDT in Breast Cancer-Related Lymphedema
Status: COMPLETED
Conditions: Breast Cancer|Lymphedema
Interventions: DEVICE: Low Level Laser Therapy|DEVICE: Low Level Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lactobacillus Rhamnosus GG Alleviates Oral Mucositis in Patients Undergoing Radiotherapy
Status: RECRUITING
Conditions: Oral Mucositis
Interventions: DIETARY_SUPPLEMENT: Lactobacillus rhamnosus GG powder|DIETARY_SUPPLEMENT: Placebo-containing tablets|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Clinical Evaluation of Soft Toric Lens Designs
Status: COMPLETED
Conditions: Astigmatism|Myopia
Interventions: DEVICE: etafilcon A|DEVICE: nelfilcon A|DEVICE: Filcon II 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Laparoscopic Endometrioma Stripping Versus Ethanol Sclerotherapy( CLESS)
Status: UNKNOWN
Conditions: Endometrioma
Interventions: PROCEDURE: ethanol sclerotherapy|PROCEDURE: stripping technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-Myeloablative Allogeneic Stem Cell Transplantation
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Rituximab|DRUG: Alemtuzumab|PROCEDURE: Allogeneic Stem Cell Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Exploration Study With Birabresib (MK-8628) in Participants With Selected Advanced Solid Tumors (MK-8628-006)
Status: TERMINATED
Conditions: NUT Midline Carcinoma (NMC)|Triple Negative Breast Cancer (TNBC)|Non-small Cell Lung Cancer (NSCLC)|Castration-resistant Prostate Cancer (CRPC)
Interventions: DRUG: Birabresib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Bone Marrow-Derived CD34+, CD133+, and CD271+ Stem Cell Transplantation for Retinitis Pigmentosa
Status: UNKNOWN
Conditions: Retinitis Pigmentosa
Interventions: BIOLOGICAL: Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Efficacy of Enhanced Recovery After Surgery (ERAS) on Length of Stay Among Laparotomy Patients at Mbarara Regional Referral Hospital
Status: COMPLETED
Conditions: Laparotomy
Interventions: DIETARY_SUPPLEMENT: Carbohydrate drink load|COMBINATION_PRODUCT: Enhanced Recovery After Surgery (ERAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: the Efficacy and Safety of Dalpiciclib Combined With Third-generation EGFR-TKI in Patients With EGFR Mutation and Meningial Metastasis in Non-small Cell Lung Cancer Progressing Through Third-generation TKI and Platinum-containing Two-drug Chemotherapy
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer Confirmed by Histopathology or Cytology|The TNM (8th) Phase is IV|With EGFR Mutations|Meningeal Progression Occurred After Previous Platinum-containing Two-drug Chemotherapy and Third-generation EGFR-TKI Treatment|Male or Female|The Age of 18 Years Old or More|ECOG PS 0 to 2 Points
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Systemic Lupus Erythematosus (SLE) With N-acetylcysteine
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: N-acetylcysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Resveratrol for Exudative Age-Related Macular Degeneration
Status: TERMINATED
Conditions: AMD|Age-related Macular Degeneration|Choroidal Neovascularisation
Interventions: DIETARY_SUPPLEMENT: Resvega|DIETARY_SUPPLEMENT: Trans-Resveratrol|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: aPDT for the Remediation of Dental Black Stain
Status: COMPLETED
Conditions: Dental Plaque|Tooth Discoloration
Interventions: PROCEDURE: Dental prophylaxis|DEVICE: Antimicrobial photodynamic therapy (aPDT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adipose Derived Stem Cells in Facial Fat Grafting
Status: COMPLETED
Conditions: Facial Atrophy
Interventions: BIOLOGICAL: Stromal Vasular Fraction|PROCEDURE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IDMet (RaDiCo Cohort) (RaDiCo-IDMet)
Status: RECRUITING
Conditions: Silver Russell Syndrome|Beckwith-Wiedemann Syndrome|Transient Neonatal Diabetes Mellitus|Angelman Syndrome|Prader-Willi Syndrome|Temple Syndrome|Kagami-Ogata Syndrome|Pseudohypoparathyroidism|Familial Precocious Puberty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Improve the Clinical Outcome of Ultrasound-guided Radiofrequency Ablation by NAVIRFA® Navigation System.
Status: RECRUITING
Conditions: Radiofrequency Ablation
Interventions: DEVICE: NAVIRFA® Navigation System|DEVICE: ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Imatinib in High-risk Gastrointestinal Stromal Tumor (GIST) With C-kit Mutation
Status: COMPLETED
Conditions: Sarcoma|Gastrointestinal Stromal Tumors
Interventions: DRUG: Imatinib mesylate (Glivec)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRD-positive Colorectal Cancer Patients Combined With Personalized Immune Regulation Diagnosis
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: Conventional chemotherapy combined with personalized immune regulation diagnosis and treatment technology
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Treatment in Diabetic Patients With Grade 1 Obesity
Status: COMPLETED
Conditions: Obesity|Type 2 Diabetes Mellitus
Interventions: PROCEDURE: Gastric bypass surgery|PROCEDURE: Surgical ileal transposition with sleeve|OTHER: Clinical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nasal Packing Versus Intravenous Dexmedetomidine in Turbinate Surgeries
Status: COMPLETED
Conditions: Nasal Packing|Dexmedetomidine|Turbinate
Interventions: DRUG: Nasal packing Dexmedetomidine|DRUG: Intravenous Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of Dysport® in the Treatment of Chronic Plantar Fasciitis
Status: COMPLETED
Conditions: Chronic Plantar Fasciitis
Interventions: BIOLOGICAL: Botulinum toxin type A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Miscarriage Preventing Herbal Medicines and the Risk of Birth Defects: a Population-based Cohort Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Pregnancy|Birth Defects|Drug Exposures
Interventions: DRUG: Herbal medicines (e.g., Yunkang granules, Duzhong granules)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prospective Feasibility Study of Point-of-care Ultrasound in Suspected Aortic Dissection
Status: NOT_YET_RECRUITING
Conditions: Aortic Dissection|Emergency Ultrasound
Interventions: OTHER: ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: BNHL-2015 for Children or Adolescents in China
Status: ACTIVE_NOT_RECRUITING
Conditions: Mature B-cell Non-Hodgkin Lymphoma
Interventions: DRUG: Prednisone,Vincristine, Cyclophosphamide|DRUG: Cyclophosphamide, Vincristine, Cytarabine, Doxorubincin, Prednisone|DRUG: Ifosphamide, Etoposide, Methotrexate, Vincristine, Prednisone|DRUG: Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone|DRUG: Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Effects of Electrical Stimulation on Speeding up Orthodontic Tooth Movement
Status: COMPLETED
Conditions: Class II Malocclusion
Interventions: DEVICE: Low-intensity electrical current (LIEC)|DEVICE: Traditional fixed orthodontic appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of SNX-001 in Healthy Aged Volunteers
Status: COMPLETED
Conditions: Safety
Interventions: DRUG: SNX-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Full Thickness Resection or Endoscopic Submucosal Dissection for Difficult Colorectal Lesions.
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: PROCEDURE: Endoscopic Full-Thickness Resection (EFTR)|PROCEDURE: Endoscopic Submucosal Dissection (ESD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of CT Guided Ablation of Cardiac Ganglionated Plexi
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: Ganglionated Plexi mapping and ablation using Natus Cortical Stimulator and standard ablation catheters
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tobacco Cessation Intervention Study for Oral Diseases
Status: UNKNOWN
Conditions: Smoking Cessation|Mouth Diseases|Periodontal Diseases|Leukoplakia|Lichen Planus|Keratosis|Implant
Interventions: OTHER: Tobacco cessation intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Camrelizumab (SHR-1210) and Apatinb Based Therapies for Alpha-fetoprotein (AFP)-Producing Gastric Cancer or Gastroesophageal Junction Adenocarcinoma
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Camrelizumab plus Apatinib and SOX|DRUG: Camrelizumab plus Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Specific Modulation Frequencies in Hepatitis B Carriers With and Without Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatitis|Hepatocellular Carcinomas
Interventions: DEVICE: Low intensity amplitude-moduled electromagnetic fields
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: InterLeukin-7 (CYT107) to Improve Clinical Outcomes in Lymphopenic pAtients With COVID-19 Infection UK Cohort
Status: TERMINATED
Conditions: COVID-19|Lymphocytopenia
Interventions: DRUG: Interleukin-7|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Efficacy of the HLPFC Coil Deep Transcranial Magnetic Stimulation System in Treating Attention Deficit and Hyperactivity Disorder (ADHD) in Adults
Status: UNKNOWN
Conditions: Attention Deficit Disorder Patients
Interventions: PROCEDURE: Transcranial Magnetic Stimulation. PFC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing Knee Osteoarthritis Through Exercise and Education Following Knee Injury
Status: UNKNOWN
Conditions: Osteoarthritis Knees Both Post-Traumatic
Interventions: OTHER: SHRED Osteoarthritis program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Alpha Lipoic Acid on Non-alcoholic Fatty Liver Diseases
Status: RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: DRUG: Placebo|DRUG: Alphalipoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Levetiracetam Treatment in Adult Subjects With Parkinson's Disease Experiencing Troublesome Dyskinesias
Status: COMPLETED
Conditions: Idiopathic Parkinson Disease
Interventions: DRUG: Levetiracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: The Influence of Dopamine Agonist Cabergoline on Oocyte Maturation
Status: COMPLETED
Conditions: In Vitro Fertilization
Interventions: PROCEDURE: the timing cabergoline administration|PROCEDURE: the timing cabergoline administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Two Simulation-Based Functional Nasopharyngoscopic Velopharyngeal Assessment Trainings
Status: COMPLETED
Conditions: Simulation Training
Interventions: BEHAVIORAL: Nasopharyngoscopic Velopharyngeal Training with 3D Printed Endoscopy Training Model|BEHAVIORAL: Nasopharyngoscopic Velopharyngeal Training with Ready-Made Endoscopy Training Model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: This Study Will Investigate the Effect of Single Oral Doses of Retosiban on Cardiac Repolarization, With Moxifloxacin as a Positive Control in Healthy Volunteers.
Status: COMPLETED
Conditions: Obstetric Labour, Premature
Interventions: DRUG: Retosiban 100 mg|DRUG: Retosiban 800 mg|DRUG: Placebo|DRUG: Moxifloxacin 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Dexamethasone Alone vs in Combination With Pericardium 6 (P6) Electrical Stimulation or Granisetron in the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Breast Cancer Surgery
Status: COMPLETED
Conditions: Mammary Cancer|PONV
Interventions: DEVICE: electric stimulation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oral Versus Rectal Ibuprofen for Fever in Young Children - a Randomized Control Study.
Status: UNKNOWN
Conditions: Fever
Interventions: DRUG: Ibuprofen suppository|DRUG: Ibuprofen Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of Six Cycles of Treatment With a Combined Oral Contraceptive (EE 0.30 mg/DRSP 3 mg) on Quality of Life.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Yasmin (30 µg EE, 3 mg Drospirenone, BAY86-5131)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Clinical Effects of Multiple Rising Subcutaneous Doses of BI 655064 in Healthy Volunteers and in Rheumatoid Arthritis Patients With Prior Inadequate Response to Methotrexate Therapy
Status: COMPLETED
Conditions: Arthritis, Rheumatoid|Healthy
Interventions: DRUG: Placebo matching BI 655064|DRUG: BI 655064
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Human Central Nervous System (CNS) Stem Cell Transplantation in Cervical Spinal Cord Injury
Status: TERMINATED
Conditions: Cervical Spinal Cord Injury|Spine Injury|Cervical Spine Injury
Interventions: DRUG: HuCNS-SC cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy of Irrigation With Epinephrine or Tranexamic Acid on Visual Clarity
Status: COMPLETED
Conditions: Rotator Cuff Tears
Interventions: DRUG: tranexamic acid|DRUG: Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A High Intensity Electronic Health Intervention for the Reduction of Learning Disparities in Childhood Cancer Survivors
Status: RECRUITING
Conditions: Acute Leukemia|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Lymphoblastic Lymphoma
Interventions: OTHER: Best Practice|OTHER: Internet-Based Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of AR1005 in Patients With Lewy Body Disease
Status: RECRUITING
Conditions: Lewy Body Dementia
Interventions: DRUG: AR1005|DRUG: Placebo|DRUG: Rivastigmine 3 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the BiovaxId Tumor Derived Idiotype Vaccine in Patients With Follicular Lymphoma
Status: UNKNOWN
Conditions: Non-Hodgkins Lymphoma
Interventions: BIOLOGICAL: FNHLId1|BIOLOGICAL: KLH + GM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irinotecan in Treating Asian Patients With Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: irinotecan hydrochloride|OTHER: pharmacogenomic studies|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Comparative Trial of Zonisamide and Topiramate as Initial Monotherapy in Untreated Epilepsies
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Zonisamide|DRUG: Topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Active Cycle Of Breathing Technique Verses Breathing Exercises In Post ICU COVID-19 Patients
Status: COMPLETED
Conditions: Post Covid-19 Patients
Interventions: OTHER: Chest physiotherapy with breathing exercises and ACBT|OTHER: Chest physiotherapy with breathing exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pulpotomy With Various MTA Materials and Ferric Sulphate
Status: COMPLETED
Conditions: Pulpotomy
Interventions: PROCEDURE: Ferric sulphate|PROCEDURE: Ortho-MTA|PROCEDURE: Retro-MTA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Vildagliptin Based Treatment Versus Sulfonylurea on Glycemic Variability, Oxidative Stress, GLP-1, and Endothelial Function in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Add Vildagliptin|DRUG: Add Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation for Treatment of Refractory Graft Versus Host Disease-a Pilot Study
Status: UNKNOWN
Conditions: Fecal Microbiota Transplantation in GVHD
Interventions: BIOLOGICAL: Fecal Microbiota Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Paxil CR on Neural Circuits in Posttraumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder (PTSD)
Interventions: DRUG: paroxetine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Two Combined Therapeutic Methods for Treatment of Lateral Epicondylitis
Status: TERMINATED
Conditions: Lateral Epicondylitis
Interventions: DRUG: Triamcinolone Acetonide- Indomethacin-Cryotherapy-Casting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AZD5153 in Patients With Relapsed or Refractory Solid Tumors, Including Lymphomas
Status: COMPLETED
Conditions: Malignant Solid Tumors|Lymphoma|Ovarian Cancer|Breast Cancer|Pancreatic Cancer|Prostate Cancer
Interventions: DRUG: AZD5153|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Distribution and Clinical Implication of CMD in Patients With HFpEF Without Significant CAD
Status: RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction|Coronary Microvascular Dysfunction
Interventions: DIAGNOSTIC_TEST: Invasive physiologic evaluation (fractional flow reserve, coronary flow reserve, index of microcirculatory resistance)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cerebral Perfusion During Neonatal Cardiac Surgery
Status: COMPLETED
Conditions: Congenital Heart Defects|Hypoplastic Left Heart Syndrome|Aortic Coarctation
Interventions: PROCEDURE: Deep Hypothermic Circulatory Arrest|PROCEDURE: Antegrade Cerebral Perfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Self-sampling Among Long-term Non-attenders to Cervical Cancer Screening
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: BEHAVIORAL: Opt-in; Receive offer to order self-sampling kit|BEHAVIORAL: Opt-out; Receive self-sampling kit unsolicited|BEHAVIORAL: Control; Receive open reminder to be screened by physician
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effect of Feeding With Nutrient Dense Formula in Malnourished Infants and Children With Congenital Heart Defects
Status: COMPLETED
Conditions: Congenital Heart Disease
Interventions: DIETARY_SUPPLEMENT: Infant formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Alcohol 70% Versus Chlorhexidine 0.5% in the Spinal Anesthesia Skin Antissepsis
Status: COMPLETED
Conditions: Anesthesia, Spinal|Anesthesia, Epidural|Antisepsis
Interventions: OTHER: alcohol antisepsis|OTHER: chlorhexidine antisepsis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Susceptibility for Entrainment: Role of Ventilator Settings on the Occurrence of Reverse Triggering and Its Physiological Consequences - the SEVeRe Study
Status: RECRUITING
Conditions: Respiration, Artificial|Reverse Triggering
Interventions: OTHER: Changes in the ventilator respiratory rate and tidal volume
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Graft-versus-host-disease
Interventions: DRUG: Axatilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Arthroscopic Patellar Denervation With High Tibial Osteotomy Improve Anterior Knee Pain
Status: COMPLETED
Conditions: Anterior Knee Pain Syndrome
Interventions: PROCEDURE: high tibial osteotomy with or without arthroscopic circumpatellar denervation with or without arthroscopic circumpatellar denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Persistence of Antibodies at 3, 4 and 6 Years of Age After Vaccination With Meningococcal, Pneumococcal and Hib Vaccines
Status: COMPLETED
Conditions: Neisseria Meningitidis|Haemophilus Influenzae Type b
Interventions: BIOLOGICAL: MenitorixTM|BIOLOGICAL: Pneumococcal conjugate vaccine GSK1024850A|BIOLOGICAL: PrevenarTM|BIOLOGICAL: MeningitecTM|BIOLOGICAL: NeisVac-CTM|BIOLOGICAL: InfanrixTM hexa|BIOLOGICAL: InfanrixTM penta|BIOLOGICAL: InfanrixTM IPV/Hib|BIOLOGICAL: InfanrixTM IPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Safety Trial of Lisocabtagene Maraleucel (JCAR017) for Relapsed and Refractory (R/R) B-cell Non-Hodgkin Lymphoma (NHL) in the Outpatient Setting (TRANSCEND-OUTREACH-007)
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin|Lymphoma|Lymphoma, B-Cell|Lymphoma, Large B-Cell, Diffuse|Neoplasms|Neoplasms by Histologic Type|Lymphoproliferative Disorders|Lymphatic Diseases|Immunoproliferative Disorders|Immune System Disorder
Interventions: BIOLOGICAL: lisocabtagene maraleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Inquiry Based Stress Reduction (IBSR) Program for BRCA1/2 Mutation Carriers
Status: UNKNOWN
Conditions: Hereditary Breast and Ovarian Cancer Syndrome
Interventions: BEHAVIORAL: Inquiry Based Stress Reduction (IBSR) program|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Pharmacokinetics, Safety, Tolerability and Pharmacodynamic Effects of a Single Oral 10 mg BAY1101042 Tablet Dose in Men and Woman With Renal Impairment and in Healthy Subjects
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: BAY1101042
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Genetic Testing for All Breast Cancer Patients (GET FACTS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Invasive Breast Cancer|in Situ Breast Cancer|Genetic Testing
Interventions: BEHAVIORAL: Standard Genetic Counseling|BEHAVIORAL: Quantitative Genetic Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Mobility and Activity Training (MAT) to Optimize Outcomes for Older Adult Abdominal Surgery Patients
Status: WITHDRAWN
Conditions: Gastrointestinal Malignancy
Interventions: BEHAVIORAL: Mobility and Activity Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical and Microbiological Evaluation of 0.5% Versus 3% Sodium Hypochlorite in Root Canal Treatment
Status: COMPLETED
Conditions: Pulpitis|Apical Periodontitis
Interventions: PROCEDURE: Irrigation with 3% NaOCl|PROCEDURE: Irrigation with 0.5% NaOCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Value of UTB and TB for PPL
Status: COMPLETED
Conditions: Peripheral Pulmonary Lesion
Interventions: PROCEDURE: Ultrathin bronchoscope|PROCEDURE: Thin bronchoscope|PROCEDURE: Virtual bronchoscopic navigation combined with endobronchial ultrasound|PROCEDURE: Guide sheath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Liraglutide on Kidney Function in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Liraglutide|DRUG: Placebo-liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Neural Mediators of Response to Trauma Management Therapy for PTSD
Status: COMPLETED
Conditions: PTSD
Interventions: OTHER: Trauma Management Therapy|OTHER: Exposure Therapy with Psychotherapy group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Performance Of Conserved Chalky White Demineralized Enamel Cavity Margins Versus Totally Removed Carious Margins In Class V Cavities Restored With Composite Resin
Status: RECRUITING
Conditions: Class V Dental Caries
Interventions: PROCEDURE: conserved chalky white enamel margins of class V cavities|PROCEDURE: Total removal of demineralized enamel margins of class V cavities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ketoconazole, Hydrocortisone, Dutasteride and Lapatinib (KHAD-L) in Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: ketoconazole|DRUG: hydrocortisone|DRUG: dutasteride|DRUG: lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMV to Accelerate Recovery of Lung Function in Veno-venous Extracorporeal Membrane Oxygenation; Lung Rest Or Moderate Mechanical Ventilation in ECMO
Status: RECRUITING
Conditions: ARDS
Interventions: OTHER: Near Apnoeic ventilation|OTHER: Crossover standardised ECMO weaning trials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hippocampus-sparing WBRT and Simultaneous Integrated Boost for Multiple Brain Metastases From NSCLC
Status: UNKNOWN
Conditions: Brain Metastases
Interventions: RADIATION: WBRT with hippocampus-sparing and SIB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Edoxaban Treatment Versus Vitamin K Antagonist (VKA) in Patients With Atrial Fibrillation (AF) Undergoing Catheter Ablation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Edoxaban|DRUG: VKA-Based Regimen|DRUG: VKA-Based Regimen|DRUG: VKA-Based Regimen|DRUG: VKA-Based Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Randomized Trial of Video-based Family Therapy for Depressed Home Visited Mothers
Status: COMPLETED
Conditions: Perinatal Depression|Postpartum Depression|Family Conflict
Interventions: BEHAVIORAL: Resilience Enhancement Skills Training|BEHAVIORAL: Problem-Solving Individual Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Evaluation of the Efficacy and Safety of Donepezil Hydrochloride in Subjects With Mild Cognitive Impairment (MCI)
Status: COMPLETED
Conditions: Memory Loss
Interventions: DRUG: Donepezil Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: BEAT AF - Braking Ectopic Atrial Trends In Atrial Fibrillation
Status: RECRUITING
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: Neuromodulation with RR2 device|DEVICE: Mock sham neuromodulation with sham RR2 device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Benazepril HCl 40 mg Tablets, Fasting
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Benazepril HCl 40 mg Tablets|DRUG: Lotensin® 40 mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: In Vivo Three-Dimensional Determination of Osteoarthritis Brace Effectiveness
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Breg Osteoarthritis Brace gait fluoroscopy|OTHER: Gait fluoroscopy without brace|DIAGNOSTIC_TEST: JointVue ultrasound|DIAGNOSTIC_TEST: Computer Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FOLFOXIRI Plus Cetuximab Versus FOLFOXIRI Plus Bevacizumab in Conversion Therapy of Right-sided Colon Cancer Liver Metastases
Status: RECRUITING
Conditions: Liver Metastasis Colon Cancer
Interventions: DRUG: Cetuximab|DRUG: Bevacizumab|DRUG: FOLFOXIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contrast-enhanced Ultrasound for Complex Kidney Lesion Diagnosis in Patients With CKD Extension
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Cystic Kidney Disease
Interventions: DRUG: Perflutren Lipid microsphere
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of the Tdap Combined Vaccine (ADACEL™) as a Booster Dose in Healthy Adults and Children in China
Status: COMPLETED
Conditions: Diphtheria|Tetanus|Pertussis
Interventions: BIOLOGICAL: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed Tdap|BIOLOGICAL: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed Tdap
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study on Ginkgo Biolba Extract Fifty and Mild Cognitive Impairment Associated With CSVD
Status: NOT_YET_RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: DRUG: Ginkgo biloba extract 50 dropping pills|DRUG: Ginkgo biloba extract Ginkgo biloba extract 50 Drops simulant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection: Phase IIa
Status: TERMINATED
Conditions: Shigella
Interventions: BIOLOGICAL: CVD 1208S, a Shigella flexneri 2a live, oral vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy Study of TEPSO® Socks in Improving Palmoplantar Psoriasis
Status: COMPLETED
Conditions: Palmoplantar Psoriasis
Interventions: DEVICE: TEPSO cloth|DEVICE: Standard cloth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Upgraded '2C3L' vs. PVI Approach for Catheter Ablation of Persistent Atrial Fibrillation
Status: COMPLETED
Conditions: Persistent Atrial Fibrillation|Catheter Ablation
Interventions: PROCEDURE: upgraded '2C3L'|PROCEDURE: pulmonary vein antral isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Salivary Galectin-8, Galectin-9 and RANKL Levels of Individuals With Different Periodontal Diseases
Status: RECRUITING
Conditions: Periodontal Diseases
Interventions: DIAGNOSTIC_TEST: saliva obtaining
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prevention of Postoperative Events Following Reversal With Sugammadex or Neostigmine
Status: TERMINATED
Conditions: Pulmonary Complications
Interventions: DRUG: Sugammadex|DRUG: Neostigmine/Glycopyrrolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Low Dose Perioperative Ketamine Infusion and it's Effect on Postoperative Pain Score, Sedation Score and Narcotic Consumption in Patients Undergoing Spine Surgery: A Prospective Randomized Double Blind Control Trial.
Status: UNKNOWN
Conditions: for Post-operative Pain Relief in Spine Surgeries
Interventions: DRUG: Ketamine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Influence of Ozone Therapy on Postoperative Pain Relief in the Surgical Treatment of Lower Third Molars: Randomized Controlled Trial
Status: RECRUITING
Conditions: Extraction of the Lower Third Molars
Interventions: OTHER: ozone therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of High Dose Olanzapine for the Treatment of Schizophrenia and Schizoaffective Disorder
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: CAPITAL: Carotid Artery Plaque Intravascular Ultrasound Evaluation
Status: COMPLETED
Conditions: Carotid Artery Disease
Interventions: PROCEDURE: IVUS|DEVICE: CAS|PROCEDURE: CEA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Treatment Modality on Psychosocial Functioning of Survivors of Unilateral Retinoblastoma
Status: ENROLLING_BY_INVITATION
Conditions: Survivors of Unilateral Retinoblastoma
Interventions: BEHAVIORAL: BASC-3 survey|BEHAVIORAL: PROMIS survey
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Influence of Resistant Starch Intake in Potatoes on Blood Glucose and Satiety Responses in Overweight Females
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: OTHER: Potatoes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Episodic Future Thinking Intervention to Promote Weight Loss in Breast Cancer Survivors
Status: ACTIVE_NOT_RECRUITING
Conditions: Anatomic Stage 0 Breast Cancer AJCC v8|Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Breast Ductal Carcinoma In Situ|Invasive Breast Carcinoma|Prognostic Stage 0 Breast Cancer AJCC v8|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8
Interventions: BEHAVIORAL: Behavioral Intervention|BEHAVIORAL: Behavioral Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioequivalence Study in Healthy Chinese Subjects Comparing SP-01 (Granisetron Patch) Manufactured at Two Different Sites
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: SP-01 manufactured by Site K (SP-01-K, Transdermal patch contained granisetron)|DRUG: SP-01 manufactured by Site A (SP-01-A, Transdermal patch contained granisetron)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Ambulatory Continuous Femoral Nerve Blocks on Readiness-for-Discharge Following Total Knee Replacement
Status: COMPLETED
Conditions: Total Knee Arthroplasty
Interventions: PROCEDURE: Ambulatory continuous femoral nerve block for 100 hours
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Omega-3 Supplementation During Pregnancy on Regulation of Stress
Status: COMPLETED
Conditions: Healthy Pregnant Women
Interventions: DIETARY_SUPPLEMENT: Docosahexanoic Acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Outcomes of Rotating Platform Versus Mobile Bearing Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Total Knee Arthroplasty
Interventions: DEVICE: Fixed bearing total knee arthroplasty|DEVICE: Rotating platform total knee arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Immunosuppression in IBD Patients on Response to Influenza Vaccine
Status: COMPLETED
Conditions: Inflammatory Bowel Disease (IBD)|Immunosuppressed or Non-Immunosuppressed|Influenza Vaccine|Antibody Titers|Seroprotective Titers
Interventions: OTHER: blood draw
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open Dose Escalating Trial to Determine the Maximum Tolerated Dose in Paediatric Patients With Advanced Cancers for Whom no Therapy is Known
Status: COMPLETED
Conditions: Leukemia|Neoplasms
Interventions: DRUG: volasertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PReclude Infection EVEnts With No Prophylaxis Transperineal Biopsy 2
Status: RECRUITING
Conditions: Infection
Interventions: PROCEDURE: Transperineal MRI-guided prostate biopsy|PROCEDURE: Transrectal MRI-guided prostate biopsy|DRUG: Antibiotic (prophylaxis)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Navitoclax and Abiraterone Acetate With or Without Hydroxychloroquine in Treating Patients With Progressive Metastatic Castrate Refractory Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Abiraterone|DRUG: ABT-263|DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT