pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of the Effectiveness and Safety of Sustained-release Hydromorphone (a Strong Opioid) in Patients With Chronic Noncancer Pain.
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: OROS hydromorphone HCl|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Restoring the Anatomic Tension Relationship of the Long Head of the Biceps During Tenodesis
Status: COMPLETED
Conditions: Biceps Tendon Disorder|Tendinosis|Rotator Cuff Injuries
Interventions: PROCEDURE: Anatomic Long Head of Biceps Tensioning Technique|PROCEDURE: Traditional Long Head of Biceps Tensioning Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Minimally Invasive Approaches to Unruptured Anterior Circulation Aneurysms
Status: UNKNOWN
Conditions: Cerebral Aneurysm|Aneurysm, Middle Cerebral Artery|Aneurysm, Anterior Communicating Artery|Aneurysm, Posterior Communicating Artery|Aneurysm, Carotid Artery|Brain Aneurysm
Interventions: PROCEDURE: Aneurysm Clipping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Web-Assisted Quitline for Smokeless Tobacco Users
Status: COMPLETED
Conditions: Tobacco Use Disorder
Interventions: BEHAVIORAL: Web + Phone|BEHAVIORAL: Web Only|BEHAVIORAL: Phone Only|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Novartis Access; a Non-communicable Disease (NCD) Access Initiative
Status: COMPLETED
Conditions: Cardiovascular Disease|Diabetes Type II|Breast Cancer|Asthma
Interventions: OTHER: Novartis Access
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Non-bridging Fixator Versus Percutaneous Pinning for Distal Radius Fractures
Status: COMPLETED
Conditions: Radius Fractures
Interventions: PROCEDURE: Radio-radial fixator|PROCEDURE: Percutaneous pinning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rescue of Infants With MCT8 Deficiency
Status: RECRUITING
Conditions: Mct8 (Slc16A2)-Specific Thyroid Hormone Cell Transporter Deficiency
Interventions: DRUG: Diiodothyropropionic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Precision Medicine Approach to Target Engagement for Emotion Regulation
Status: RECRUITING
Conditions: Emotional Regulation|Depression|Anxiety|Borderline Personality Disorder|Obsessive-Compulsive Disorder|Posttraumatic Stress Disorder|Eating Disorders
Interventions: BEHAVIORAL: Checking the Facts|BEHAVIORAL: Opposite to Emotion Action|BEHAVIORAL: Mindfulness of Current Emotions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplant and Dietary Fiber Supplementation for the Treatment of Gut Graft Versus Host Disease
Status: RECRUITING
Conditions: Intestinal Graft Versus Host Disease
Interventions: PROCEDURE: Colonoscopy|BIOLOGICAL: Fecal Microbiota Transplantation|BIOLOGICAL: Fecal Microbiota Transplantation|DIETARY_SUPPLEMENT: Nutritional Supplementation|OTHER: Survey Administration|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Add-on Simvastatin in Schizophrenia Trial
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of SP Resistance and Effectiveness of IPTp in Nigeria
Status: UNKNOWN
Conditions: Pregnancy Complications Parasitic
Interventions: DRUG: Efficacy of suphladoxine/pyrimethamine as IPTp|DRUG: Efficacy of suphladoxine/pyrimethamine as IPTp
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Examining the Efficiency of Neurofeedback Therapy on Adults With Sensory Over Responsivity
Status: COMPLETED
Conditions: Sensory Modulation Disorder|Sensory Over-Responsivity
Interventions: DEVICE: Neurofeedback treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study of OMS302 Injection in Subjects Undergoing Unilateral Cataract Extraction by Phacoemulsification.
Status: COMPLETED
Conditions: Cataract Extraction
Interventions: DRUG: OMS302|DRUG: OMS302-PE|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Mepitel Film the Prophylaxis of Radiation-Induced Skin Reactions in Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer|Radiation Dermatitis
Interventions: OTHER: Mepitel Film
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pascal Pascal Dynamic Contour Tonometer (DCT) Intraocular Pressure and Ocular Pulse Amplitude in Patients With Thyroid Related Orbitopathy: A Comparison to Goldmann Tonometer and to Muscles Characteristics on CT Scan
Status: UNKNOWN
Conditions: Thyroid Related Orbitopathy
Interventions: DEVICE: To measure the IOP (with Goldmann and Pascal DCT tonometers) and OPA (with Pascal DCT) in primary and upright gazes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy
Status: RECRUITING
Conditions: Duodenal Neoplasm|Pancreatic Neoplasm
Interventions: DRUG: Bupivacaine|DRUG: Hydromorphone|DRUG: Iopamidol|DRUG: Liposomal Bupivacaine|OTHER: Medical Chart Review|OTHER: Questionnaire Administration|DRUG: Thoracic Epidural Analgesia|PROCEDURE: Ultrasound Imaging|PROCEDURE: X-Ray Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Circumcision Versus Preputioplasty for BXO in Children
Status: COMPLETED
Conditions: Balanitis Xerotica Obliterans (BXO)
Interventions: PROCEDURE: circumcision|PROCEDURE: preputioplasty with intralesional injection of triamcinolone:
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pioglitazone and Tyrosine Kinase Inhibitor in Treating Patients With Relapsed Chronic Myeloid Leukemia
Status: TERMINATED
Conditions: Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Interventions: DRUG: Pioglitazone|DRUG: Tyrosine Kinase Inhibitor (TKI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers of Inflammation and Endothelial Dysfunction in Patients With Myocardial Infarction With Non-obstructive Coronary Arteries
Status: RECRUITING
Conditions: Myocardial Infarction|MINOCA|Inflammation|Biomarkers|Endothelial Dysfunction
Interventions: DIAGNOSTIC_TEST: Coronariography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Nutritional Supplement Shakes in People About to Receive Their Debulking Surgery for Ovarian Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Debulking Surgery for Ovarian Cancer
Interventions: DIETARY_SUPPLEMENT: Ensure Surgery Immunonutrition Shake supplements|OTHER: Daily Food Intake form
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy Study of REOLYSIN® in the Treatment of Bone and Soft Tissue Sarcomas Metastatic to the Lung
Status: COMPLETED
Conditions: Osteosarcoma|Ewing Sarcoma Family Tumors|Malignant Fibrous Histiocytoma|Sarcoma, Synovial|Fibrosarcoma|Leiomyosarcoma
Interventions: BIOLOGICAL: REOLYSIN®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3039478 in Participants With Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor|Breast Cancer|Colon Cancer|Cholangiocarcinoma|Soft Tissue Sarcoma
Interventions: DRUG: LY3039478|DRUG: Taladegib|DRUG: Abemaciclib|DRUG: Cisplatin|DRUG: Gemcitabine|DRUG: Carboplatin|DRUG: LY3023414
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Open Label Study to Assess the PK/PD Properties of RUC-4 in Patients With a ST-elevation Myocardial Infarction
Status: COMPLETED
Conditions: Coronary Disease|Myocardial Infarction|Heart Diseases|Vascular Diseases|STEMI - ST Elevation Myocardial Infarction
Interventions: DRUG: RUC-4 Compound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Interest of the IRAP Protein (Insulin Regulated Amino Peptidase) in Insulin Resistance
Status: TERMINATED
Conditions: Insulin Resistance Syndrome
Interventions: DIAGNOSTIC_TEST: Dosage of IRAP during OGTT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE I)
Status: COMPLETED
Conditions: Atrial Fibrillation|Cardiovascular Disease
Interventions: DRUG: Irbesartan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Infrared Ray Heat Treatment in Liver Cirrhosis Patients With Refractory Ascites
Status: UNKNOWN
Conditions: Liver Cirrhosis|Refractory Ascites
Interventions: RADIATION: Infrared ray heat treatment|OTHER: conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Imatinib to Convert Triple Negative Breast Cancer Into ER-positive Breast Cancer (I-CONIC)
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Triple Negative Breast Cancer
Interventions: DRUG: Imatinib 400 MG Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety Study of Bevacizumab, Everolimus and LBH589 (BEL) for Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: Bevacizumab, Everolimus and LBH589
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Performance of the AccuCinch® Ventricular Repair System - The CorCinch-EU Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure|Cardiomyopathies
Interventions: DEVICE: Left ventricular restoration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pectoral Nerves Blocks for Chronic Pain
Status: UNKNOWN
Conditions: Breast Neoplasms
Interventions: DRUG: Ropivacaine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Various Treatments in Non-alcoholic Fatty Liver Disease (NAFLD) Patients Who Have Aspects of Non-alcoholic Steatohepatitis (NASH)
Status: TERMINATED
Conditions: Non-alcoholic Fatty Liver Disease|Nonalcoholic Steatohepatitis
Interventions: DRUG: LYS006|DRUG: Tropifexor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Acceptability and Efficacy of a Long-term Intervention With a Diabetes-specific Low-carbohydrate, High-mono-unsaturated Fatty Acid Containing Oral Nutritional Supplement on Glycaemic Control in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Diabetes
Interventions: DIETARY_SUPPLEMENT: Oral nutritional supplement, food for special medical purposes|DIETARY_SUPPLEMENT: Oral nutritional supplement, food for special medical purposes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomised Study Comparing the Effects of Inhaled FF/GW642444M Combination, FF and GW642444M on an Allergen Induced Asthmatic Response
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: FF/GW642444M|DRUG: GW642444M|DRUG: Fluticasone Furoate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Roll-over Study to Allow Continued Access to Ribociclib
Status: RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Ribociclib|DRUG: Letrozole|DRUG: Anastrozole|DRUG: Goserelin|DRUG: Tamoxifen|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recovery of Performance, Muscle Damage and Neuromuscular Fatigue Following Muscle Power Training
Status: TERMINATED
Conditions: Power Training Exercise Protocols
Interventions: OTHER: Core exercises protocol|OTHER: Structural exercises protocol|OTHER: Accentuated eccentric load exercises protocol|OTHER: Control condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Relationship Between Normal Saline Infusion and Acute Kidney Injury in Heat Stroke
Status: RECRUITING
Conditions: Heat Stroke
Interventions: DRUG: Normal Saline infusion and Ringer lactate infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Bupivacaine Application on Postthyroidectomy Pain
Status: COMPLETED
Conditions: Thyroid Disease|Analgesia
Interventions: PROCEDURE: Thyroidectomy|DRUG: Bupivacaine|DRUG: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Treatment Algorithm for Patients With Patellofemoral Pain Syndrome
Status: COMPLETED
Conditions: Patellofemoral Pain Syndrome
Interventions: OTHER: Impairment based approach|OTHER: PFPS Algorithm approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Everolimus-Eluting Stent for Bifurcation Coronary Lesions: Comparison of Simple Versus Complex Techniques
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: Xience V Everolimus Eluting Coronary Stent System. Abbott Laboratories. Abbott Park, Illinois, U.S.A.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-medication With Alfentanil vs Placebo During ECT
Status: COMPLETED
Conditions: Blood Pressure|Electroconvulsive Therapy
Interventions: DRUG: Alfentanil|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intrathecal Dexamethasone on Intra-operative Hemodynamic in Elderly Patients Undergoing Urologic Endoscopic Surgery
Status: UNKNOWN
Conditions: Dexamethasone|Urologic Endoscopic Surgery
Interventions: DRUG: Dexamethasone|DRUG: Bupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3
Status: TERMINATED
Conditions: Middle-ear Function
Interventions: OTHER: varied middle-ear pressure|DRUG: varied middle-ear gas composition|OTHER: varied ear-canal pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of Dry Needling Versus Cupping Therapy for Pain in Piriformis Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Piriformis Syndrome
Interventions: DIAGNOSTIC_TEST: Dry Needling Group|OTHER: Cupping Therapy Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: An Open-Label Extension Study of Palovarotene Treatment in Fibrodysplasia Ossificans Progressiva (FOP)
Status: COMPLETED
Conditions: Fibrodysplasia Ossificans Progressiva
Interventions: DRUG: Palovarotene dose level 1|DRUG: Palovarotene dose level 2|DRUG: Palovarotene dose level 3|DRUG: Palovarotene dose level 4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Health Habits in Impoverished Populations
Status: COMPLETED
Conditions: Diabetes|Chronic Diseases
Interventions: BEHAVIORAL: Self-Care Stimulating Disease Prevention Program|BEHAVIORAL: Fighting Cancer with Advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Olaparib in gBRCA Mutated Pancreatic Cancer Whose Disease Has Not Progressed on First Line Platinum-Based Chemotherapy
Status: COMPLETED
Conditions: Germline BRCA1/2 Mutations and|Metastatic Adenocarcinoma of the Pancreas
Interventions: DRUG: Olaparib|DRUG: Olaparib|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Autologous Platelet-Rich Plasma for Erectile Dysfunction.
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Autologous Platelet Rich Plasma|OTHER: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Objective Visual Acuity Measurement Using Suppression of the Optokinetic Nystagmus (OKN).
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DIAGNOSTIC_TEST: Visual acuity testing with SW , Landolt-"C" and Tumbling-"E" symbols
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of Whey, Rice and Potato pRotein isOlates on appeTite rEgulatIoN in Healthy Men
Status: COMPLETED
Conditions: Appetite and General Nutritional Disorders
Interventions: DIETARY_SUPPLEMENT: Whey protein isolate|DIETARY_SUPPLEMENT: Potato protein isolate|DIETARY_SUPPLEMENT: Rice protein isolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparing the Use of Vitamin c (Ascorbic Acid) in Eye Burn in Subconjunctival Injection to Topical or Oral Treatment.
Status: WITHDRAWN
Conditions: Burn
Interventions: DIETARY_SUPPLEMENT: vitamin c|DIETARY_SUPPLEMENT: vitamin c|DIETARY_SUPPLEMENT: vitamin c
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Study to Evaluate Morning Testosterone Normalization in Overweight Men With Secondary Hypogonadism
Status: COMPLETED
Conditions: Secondary Hypogonadism
Interventions: DRUG: enclomiphene citrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Single-Dose, Randomized, Placebo- and Active-Control, Four-Way, Cross-Over Study for the Evaluation of the Effect of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) on the QT/QTc Intervals in Adult Healthy Subjects
Status: COMPLETED
Conditions: TQT Study
Interventions: DRUG: Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) + Placebo|DRUG: Moxifloxacin 400mg|OTHER: Placebo for Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr)|DRUG: Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Photobiomodulation in the Rehabilitation of Olfactory Dysfunctions Induced by Long COVID-19
Status: RECRUITING
Conditions: Anosmia|Ageusia|COVID-19|Rehabilitation|Laser Therapy
Interventions: DEVICE: low-intensity laser treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Auricular Vagus Nerve Stimulation for Meniere Disease
Status: COMPLETED
Conditions: Meniere Disease
Interventions: OTHER: Transcutaneous Auricular Vagus Nerve Stimulation with Betahistine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trial of Topotecan With VX-970 (M6620), an ATR Kinase Inhibitor, in Small Cell Cancers and Extrapulmonary Small Cell Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Non-Small -Cell Lung|Ovarian Neoplasms|Small Cell Lung Carcinoma|Uterine Cervical Neoplasms|Carcinoma, Neuroendocrine|Extrapulmonary Small Cell Cancer
Interventions: DRUG: Topotecan|DRUG: VX-970 (M6620)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SARS-CoV-2 Seroprevalence Among Nursing Home Staff and Residents (COVID-19)
Status: COMPLETED
Conditions: Covid19|SARS-CoV-2 Infection
Interventions: DIAGNOSTIC_TEST: Point-of-care rapid anti-SARS-CoV-2 antibody test (Orient Gene Biotech) and Dry Blood Spot collection (Euroimmun)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Mount Sinai Diabetic Foot Ulcer Prospective Trial
Status: RECRUITING
Conditions: Diabetes|Diabetic Foot Ulcer|Edema
Interventions: DEVICE: Conventional Therapy|DEVICE: Venous Stent(s)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of SBRT in Combination With rhGM-CSF for Stage IV NSCLC Patients Who Failed in Second-line Chemotherapy
Status: WITHDRAWN
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: RADIATION: Stereotactic body radiotherapy|DRUG: rhGM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transdiagnostic Intervention to Reduce Internalized Health-Related Stigma
Status: NOT_YET_RECRUITING
Conditions: Obesity|Skin Disease|Cancer|HIV|Diabetes|Chronic Pain
Interventions: BEHAVIORAL: Healing HEARTS|BEHAVIORAL: Peer Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proximal Tibial Osteotomy Osteoclasis In Infantile Genu-Varum
Status: COMPLETED
Conditions: Deformity Knee|Deformity of Limb
Interventions: PROCEDURE: osteotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Ciclesonide for Outpatients With COVID19
Status: TERMINATED
Conditions: COVID 19
Interventions: DRUG: Normal Saline intranasal and placebo inhaler|DRUG: Ciclesonide|DRUG: Ciclesonide nasal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Volatolom Variation in Severe COPD During Hospitalization for Exacerbation and After Hospitalization (VOC-BPCO-Exa)
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease Exacerbation
Interventions: DEVICE: VOC analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pilot Phase I/II Study of Amino Acid Leucine in Treatment of Patients With Transfusion-Dependent Diamond Blackfan Anemia
Status: COMPLETED
Conditions: Diamond Blackfan Anemia|Blackfan Diamond Syndrome|DBA|Congenital Hypoplastic Anemia|Pure Red Cell Aplasia
Interventions: DRUG: leucine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serum Opiorphin Level After Intraoperative Intravenous Lidocaine Infusion
Status: COMPLETED
Conditions: Cancer, Breast
Interventions: DRUG: Lidocaine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: GlideScope Groove Versus Macintosh Blade for Double-Lumen Endotracheal Tube Intubation
Status: WITHDRAWN
Conditions: Intubation, Intratracheal
Interventions: DEVICE: GlideScope Groove|DEVICE: Control: Macintosh blade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of HIV DNA-C CN54ENV and Recombinant HIV CN54gp140 Vaccines in Healthy Volunteers
Status: COMPLETED
Conditions: HIV
Interventions: BIOLOGICAL: DNA-C CN54ENV|BIOLOGICAL: CN54gp140|DEVICE: Trigrid Delivery System - Intramuscular|DEVICE: Trigrid Delivery System - Intradermal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Steady State Tipranavir/Ritonavir or Darunavir/Ritonavir or Ritonavir on Platelet Function, Coagulation and Fibrinolysis Biomarkers in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tipranavir|DRUG: Ritonavir|DRUG: Darunavir|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Angiotensin Receptor Blockade as an Anti-Fibrotic Intervention in Patients With Chronic Hepatitis C
Status: WITHDRAWN
Conditions: Hepatitis C
Interventions: DRUG: Candesartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ARRY-614 in Patients With Low or Intermediate-1 Risk Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: ARRY-614, p38/Tie2 inhibitor; oral
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Positive Pressure Extubation Reduce Postoperative Desaturation?
Status: UNKNOWN
Conditions: Extubation|Postoperative Complications|Lung Ultrasound Score
Interventions: PROCEDURE: positive pressure during extubation procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Sulfatinib in Treating Advanced Medullary Thyroid Carcinoma and Iodine-refractory Differentiated Thyroid Carcinoma
Status: COMPLETED
Conditions: Thyroid Carcinoma
Interventions: DRUG: Surufatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Titanium-prepared Platelet-rich Fibrin in Periodontal Regeneration
Status: COMPLETED
Conditions: Platelet-Rich Fibrin
Interventions: PROCEDURE: periodontal surgical procedure (open flap debridement)|PROCEDURE: periodontal surgical procedure (OFD +autogenous Titanium-prepared platelet-rich fibrin (OFD+ T-PRF))
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Deucravacitinib on Quality of Life in Participants With Plaque Psoriasis in a Community Setting
Status: ACTIVE_NOT_RECRUITING
Conditions: Psoriasis
Interventions: DRUG: Deucravacitinib|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Orally Administered Beta-glucan on Leukocyte Function in Humans
Status: COMPLETED
Conditions: Immunologic Deficiency Syndromes
Interventions: DIETARY_SUPPLEMENT: Beta-glucan (Glucan #300®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety Study of Pandemic Candidate Influenza Vaccines in the Elderly Population
Status: COMPLETED
Conditions: Influenza|Influenza Vaccines
Interventions: BIOLOGICAL: SB218352_15|BIOLOGICAL: SB218352_8|BIOLOGICAL: SB218352_4|BIOLOGICAL: SB218352_2|BIOLOGICAL: SB218352_8AL|BIOLOGICAL: SB218352_4AL|BIOLOGICAL: SB218352_2AL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Integrated Analysis of the Effectiveness of Intravitreal (IVT) Aflibercept (Eylea) in Routine Clinical Practice Based on Two Large Observational Studies
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DRUG: Eylea (Aflibercept, VEGF Trap-Eye, BAY86-5321)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fluorescence Laparoscopic Navigation for Rectal Cancer and Sigmoid Colon Cancer
Status: NOT_YET_RECRUITING
Conditions: Colorectal Neoplasms|Fluorescence|Lymph Node Excision
Interventions: PROCEDURE: lymph node dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Performance and Safety of YVOIRE Y Solution 360 Versus Comparator for Lips and Perioral Area.
Status: TERMINATED
Conditions: Lip Augmentation
Interventions: DEVICE: YVOIRE Y-Solution 360|DEVICE: Juvéderm VOLBELLA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Extension From RCC Phase II (11515)
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Sorafenib (Nexavar, BAY43-9006)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rate of Torque Development in Adolescents With Osgood-Schlatter
Status: COMPLETED
Conditions: Osgood-Schlatter Disease
Interventions: OTHER: Rate of torque development testing of knee flexors and knee extensors using a fixated handheld dynamometer (MicroFet 2, Hoggan, Scientific L.L.C., Salt Lake City, USA), sampling rate of 100hz)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pegylated Interferon and Ribavirin in Hepatitis C Patients on Opioid Pharmacotherapy
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Pegylated interferon and ribavirin|DRUG: Pegylated interferon and ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lanreotide Autogel in the Treatment of Symptomatic Polycystic Liver Disease
Status: COMPLETED
Conditions: Polycystic Liver Disease
Interventions: DRUG: Lanreotide Autogel 90 mg and 120 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography for the Diagnosis of Immune Checkpoint Inhibitor-Related Myocarditis
Status: COMPLETED
Conditions: Myocarditis Acute
Interventions: PROCEDURE: Computed Tomography|OTHER: Fludeoxyglucose F-18|OTHER: Low Carbohydrate High Fat Diet|PROCEDURE: Positron Emission Tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Observational Study of Combination of Pegylated Liposomal Doxorubicin and Trabectedin in Routine Practice in Patients With Recurrent Partial-platinum Sensitive Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: DRUG: Trabectedin + PLD
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Oxaliplatin, Capecitabine, and Radiation Therapy With or Without Cetuximab in Treating Patients Undergoing Surgery for High-Risk Rectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: capecitabine|DRUG: oxaliplatin|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study Alimta and Gemzar + Avastin as First Line Chemotherapy for Elderly Patients With Stage IIIB/IV NSCLC
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Pemetrexed and Gemcitabine plus Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study of Donafenib in Patients With Radioiodine-refractory Differentiated Thyroid Cancer
Status: TERMINATED
Conditions: Differentiated Thyroid Cancer
Interventions: DRUG: Donafenib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peptide Vaccination in Combination With Azacitidine for Patients With MDS and AML
Status: COMPLETED
Conditions: Myelodysplastic Syndrome|Acute Myeloid Leukemia
Interventions: BIOLOGICAL: NPMW-peptide vaccine|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Doxycycline on Metakaryote Cell Death in Patients With Resectable Pancreatic Cancer
Status: COMPLETED
Conditions: Resectable Pancreatic Cancer
Interventions: DRUG: Doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weekly Oxaliplatin and Gemcitabine for Recurrent or Metastatic Head and Neck Cancer
Status: TERMINATED
Conditions: Cancer of the Head and Neck
Interventions: DRUG: Gemcitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Timing of Treatment Completion in Staged Selective Laser Trabeculoplasty (SLT): Early vs. Late Completion
Status: TERMINATED
Conditions: Glaucoma
Interventions: PROCEDURE: selective laser trabeculoplasty - early completion|PROCEDURE: Selective laser trabeculoplasty - late completion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of High Protein Diet on Adiponectin and Inflammation Among Overweight and Obese Children
Status: COMPLETED
Conditions: Body Mass Index Quantitative Trait Locus 5 Disorder|Tangier Disease
Interventions: OTHER: nutrition intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: PET Imaging With [18F]F-AraG in Advanced Non-small Cell Lung Cancer (NSCLC)
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: DRUG: [18F]F-AraG Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Chronotype and Premature Ejaculation
Status: COMPLETED
Conditions: Premature Ejaculation
Interventions: DIAGNOSTIC_TEST: Intravaginal ejaculatory latency time (IELT), Arabic Index of Premature Ejaculation (AIPE), Morningness-Eveningness Questionnaire (MEQ)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Efficacy and Safety Study of Sodium Oligomannate (GV-971) for the Treatment of Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer's Disease
Interventions: DRUG: GV-971|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Pharmacodynamics of Levobupivacaine During Continuous Caudal Epidural Analgesia in Newborns
Status: COMPLETED
Conditions: Analgesia
Interventions: DIAGNOSTIC_TEST: Blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Herpes Simplex Type 1 Suppression in Hepatitis C
Status: COMPLETED
Conditions: Chronic Hepatitis C Infection
Interventions: DRUG: Valacyclovir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Observe the Dual-target Chimeric Antigen Receptor T Cells in the Treatment of B Cell Hematologic Tumors
Status: RECRUITING
Conditions: 19 and 22+ B Cell Hematologic Tumors|19 and 20+ B Cell Hematologic Tumors
Interventions: BIOLOGICAL: Autologous CD19/CD22/CD20 Chimeric Antigen Receptor T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MemoryXL Effects on Mild Cognitive Impairment Patients
Status: TERMINATED
Conditions: Mild Cognitive Impairment
Interventions: DRUG: Memory XL|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Value of the Follow-up of CALCIneurin Activity to MOdulate Calcineurin Inhibitors-induced Immunosuppression in Lung Transplantation
Status: UNKNOWN
Conditions: Lung Diseases
Interventions: BIOLOGICAL: levels of CNI in whole blood|BIOLOGICAL: Calcineurin activity (CN-a) in peripheral blood mononuclear cells (PBMCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Anterior Cruciate Ligament (ACL) Reconstruction: Single Bundle Versus Double Bundle
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament Tear
Interventions: PROCEDURE: acl reconstruction - double bundle technique|PROCEDURE: acle reconstruction - single bundle technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Abnormal Contraction or Twitch of the Eyelid
Status: COMPLETED
Conditions: Bilateral Blepharospasm (BEB)
Interventions: DRUG: IncobulinumtoxinA (Xeomin), 25 Units|DRUG: IncobotulinumtoxinA (Xeomin), 12.5 Units|DRUG: Placebo|DRUG: IncobotulinumtoxinA (Xeomin), 35 Units
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Two Isometric Exercises in the Reduction of the Blood Pressure in People With Resistant Hypertension
Status: RECRUITING
Conditions: Resistant Hypertension
Interventions: OTHER: Isometric exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acetylsalicylic Acid in the Prevention of Severe SARS-CoV2 Pneumonia in Hospitalised Patients With COVID-19
Status: UNKNOWN
Conditions: COVID-19|Thrombosis Pulmonary
Interventions: DRUG: Acetylsalicylic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus|Obesity
Interventions: DIETARY_SUPPLEMENT: Hydrolyzed pine nut oil|DIETARY_SUPPLEMENT: Hydrolyzed pine nut oil and olive oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Nicotine Sublingual Tablets Versus Nicorette Lozenge in Healthy Smokers
Status: COMPLETED
Conditions: Tobacco Use Disorder|Cigarette Smoking
Interventions: DRUG: Sublingual tablet 4 mg versus Nicorette Lozenge 4mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Evaluation of External Thermomechanical Stimulation for Pain Reduction in Patients Undergoing Nail Injection
Status: WITHDRAWN
Conditions: Nail Diseases
Interventions: DEVICE: External thermomechanical device delivering cold and vibration stimuli|DEVICE: External thermomechanical device without delivering cold and vibration stimuli|DRUG: Ethyl chloride skin refrigerant spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Applying Liquid Skin Barrier Film to Prevent Skin Complications Around Indwelling Vascular Catheters in Pediatric Patients: a Randomized Controlled Trial
Status: RECRUITING
Conditions: Skin Injury|Skin Allergy
Interventions: DEVICE: Skin barrier film
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PNF Strengthening and De-lorme and Watkins Exercises on Upper Extremity Function and Strength in Stroke Patients
Status: RECRUITING
Conditions: Upper Extremity Paresis
Interventions: OTHER: PNF strengthening exercises|OTHER: de-lorme and watkins exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of 3 Oral Self-care Regimens on Clinical Signs of Inflammation and Plaque
Status: COMPLETED
Conditions: Gingivitis
Interventions: DEVICE: Waterpik Water Flosser|DEVICE: Oral-B Water Flosser|DEVICE: Waxed Dental Floss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Investigator-initiated Pilot Study to Investigate the Efficacy and Safety of Immuncell-LC in Combination With Nivolumab (Opdivo) in Subjects With Advanced or Recurrent Gastric Cancer
Status: UNKNOWN
Conditions: Relapsed or Advanced Gastric Adenocarcinoma|Gastro-esophageal Junction Cancer
Interventions: DRUG: autologous activated T lymphocyte
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Immunogenicity of KBP-V001 Quadrivalent Influenza Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Low dose|BIOLOGICAL: Intermediate dose|BIOLOGICAL: High dose|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Valacyclovir Monotherapy in Pain Management of Acute Periapical Abscesses After Emergency Chamber Opening
Status: RECRUITING
Conditions: Acute Apical Abscess
Interventions: DRUG: Valacyclovir 500 mg|DRUG: Naproxen Sodium 550mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Axitinib For The Treatment Of Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Axitinib (AG-013736)|OTHER: Best Supportive Care|DRUG: Placebo|OTHER: Best Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Maintaining Behavior Change: An Evaluation of a Habit-based Sleep Health Intervention
Status: RECRUITING
Conditions: Circadian Dysregulation
Interventions: BEHAVIORAL: Habit-based Sleep Health Intervention|BEHAVIORAL: Text messaging intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Dose to Study the Safety, Tolerability, PK and PD Effects of AEF0117
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: AEF0117|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drinking Effect of Electrolyzed Alkaline Reduced Water on Oxidative Stress and Fatigue After Intense Exercise
Status: COMPLETED
Conditions: Oxidative Stress
Interventions: DEVICE: Electrolyzed alkaline reduced water generator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING