pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Quizartinib With Azacitidine or Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
Status: COMPLETED
Conditions: FLT3 Gene Mutation Negative|FLT3 Internal Tandem Duplication Positive|Recurrent Acute Myeloid Leukemia|Recurrent Chronic Myelomonocytic Leukemia|Recurrent Myelodysplastic Syndrome|Refractory Acute Myeloid Leukemia|Refractory Chronic Myelomonocytic Leukemia|Refractory Myelodysplastic Syndrome
Interventions: DRUG: Azacitidine|DRUG: Cytarabine|DRUG: Quizartinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mos-FED (Mosaicism in Focal Epilepsy Cortical Dysplasia Tissue)
Status: RECRUITING
Conditions: Focal Cortical Dysplasia|Epilepsy
Interventions: GENETIC: Blood and nasal swab sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of FID 114657 in Sjogren's Syndrome Subjects
Status: COMPLETED
Conditions: Sjogren's Syndrome
Interventions: OTHER: FID 114657 (ORB Preserved Ocular Emulsion)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid-sparing Versus Sevoflurane Anesthesia on Early Postoperative Hypoventilation in Laparoscopic Bariatric Surgery
Status: NOT_YET_RECRUITING
Conditions: Anesthesia|Hypoventilation|Opioid Use|Bariatric Surgery
Interventions: DRUG: Opioid-sparing based anesthesia|DRUG: Sevoflurane-based anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Effect of Granisetron on Myofascial Pain in the Orofacial Muscles
Status: COMPLETED
Conditions: Myofascial Pain|Temporomandibular Disorders
Interventions: DRUG: Granisetron|DRUG: Control (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Guided Transversus Abdominis Plane Block for Postoperative Analgesia After Pediatric Laparoscopic Surgery.
Status: UNKNOWN
Conditions: Analgesia
Interventions: PROCEDURE: TAB Block|PROCEDURE: Psoas Block|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study to Compare Morphine 6-glucuronide (M6G) and Morphine in Patients Suffering With Post-Operative Pain for at Least 24 Hours
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Morphine 6-glucuronide|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validating Reward-related Biomarkers (RTOC)
Status: COMPLETED
Conditions: Schizophrenia|Depression|Motivation|Anhedonia, Physical|Anhedonia, Social|Negative Symptoms With Primary Psychotic Disorder
Interventions: BEHAVIORAL: Self-rating Questionnaires|BEHAVIORAL: Measures of Reward processing/reinforcement learning|BEHAVIORAL: Additional Schizophrenia-specific Questionnaires and Interviews
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combined Alternating Sunitinib and Bevacizumab (Avastin®) in Advanced Renal Cell Carcinoma (CASA)
Status: UNKNOWN
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Sunitinib|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate of PM8002 Combined With PM1009 in Patients With First-line HCC
Status: NOT_YET_RECRUITING
Conditions: HCC|Liver Cancer
Interventions: DRUG: PM8002|DRUG: PM1009|DRUG: atezolizumab|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: WHOle Brain Irradiation or STEreotactic Radiosurgery for Five or More Brain Metastases (WHOBI-STER)
Status: RECRUITING
Conditions: Neurocognitive Deficit|Quality of Life|Activities of Daily Living
Interventions: RADIATION: Stereotactic RadioTherapy|RADIATION: Whole Brain Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Abutment Configuration on Peri-implant Soft and Hard Tissue in the Esthetic Zone - Randomized Clinical Trial
Status: RECRUITING
Conditions: Dental Implants, Single-Tooth|Dental Implant-Abutment Design
Interventions: DEVICE: CAD/CAM custom ZrO2 healing abutment|DEVICE: Cylindrical ZrO2 healing abutment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Description of the Use of fidAxomicin in Hospitalized Patients With Documented Clostridium diFficile iNfection and of the managEment of These Patients
Status: COMPLETED
Conditions: Clostridium Difficile Infection
Interventions: DRUG: Fidaxomicin|DRUG: Treatment for CDI other than fidaxomicin Type
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of the Feasibility of a Systematic Multidimensional Evaluation of the Outcome of Traumatic Brain Injury Patients and Their Relatives.
Status: RECRUITING
Conditions: Traumatic Brain Injury
Interventions: OTHER: Completion of questionnaires and on-site visits during an 18 months follow-up after TBI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase Ib/II Study of M3814 With Etoposide and Cisplatin in Small Cell Lung Cancer (SCLC) Extensive Disease (ED)
Status: TERMINATED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: M3814|DRUG: Cisplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Massage After CABG on Pain, Sleep Quality and Serum Cortisol Level
Status: COMPLETED
Conditions: Nursing Care|Massage|Pain|Cortisol
Interventions: OTHER: Massage group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment Monitoring in Autism Spectrum Disorder (ASD) in Children
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Autism|Developmental Delay|Autism, Early Infantile|Autism, Infantile
Interventions: BEHAVIORAL: Assessment by Expert Clinician During Behavioral Intervention (ABA or similar)|DEVICE: Assessment by the EarliPoint Assessment For Autism Spectrum Disorder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Concordance Between the Foot-to-Apex Systolic Interval and the Auscultatory Method for Measurement of Brachial Systolic Pressure in Patients With Severe Renal Failure
Status: COMPLETED
Conditions: Renal Insufficiency
Interventions: DIAGNOSTIC_TEST: Systolic blood pressure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Anesthesia Preference for Intravitreal Injection: Topical or Subconjunctival
Status: COMPLETED
Conditions: Age-related Macular Degeneration|Central Retinal Vein Occlusion|Diabetic Macular Edema
Interventions: PROCEDURE: Xylocaine 2% Injectable Anesthetic|DRUG: Proparacaine Hydrochloride 0.5% Drop|DRUG: Tetravisc 0.5% Gel|DRUG: Acuvail|DRUG: Intra-vitreal Anti-VEGF Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of W-3 Polyunsaturated Fatty Acids on Serum Albumin Concentration in Patients With Acute Heart Failure, Hypoalbuminemia, and High Inflammatory Activity
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Polyunsaturated fatty acids omega-3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ph I Oral Topotecan and Temozolomide for Patients With Malignant Gliomas
Status: COMPLETED
Conditions: Glioblastoma|Gliosarcoma|Anaplastic Astrocytoma
Interventions: DRUG: Oral Topotecan and Temodar
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypomethylating Agent and Venetoclax After Allo-HSCT in Patients With High-risk Myeloid Malignancies.
Status: RECRUITING
Conditions: Hypomethylating Agent|Venetoclax|Myeloid Malignancy
Interventions: DRUG: Venetoclax|DRUG: Azacitidine or decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Ethanol on Intestinal Permeability and Gut Hormones
Status: COMPLETED
Conditions: Insulin Resistance|Ethanol|Incretin Effect
Interventions: OTHER: Ethanol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of DEB-BACE With Sequential Arotinib and Tirelizumab in the Treatment of Advanced NSCLC
Status: NOT_YET_RECRUITING
Conditions: Carcinoma, Non-Small Cell Lung
Interventions: DRUG: sequential DEB-BACE and Arotinib and Tirelizumab|DRUG: DEB-BACE alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone for Postoperative Nausea and Vomiting
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Dexamethasone|DRUG: Ondansetron|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Montelukast in Perennial Allergic Rhinitis - 2001-2002 Study (0476-246)
Status: COMPLETED
Conditions: Perennial Allergic Rhinitis
Interventions: DRUG: montelukast sodium|DRUG: Comparator: cetirizine|DRUG: Comparator: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Daunorubicin Hydrochloride, Cytarabine, and Nilotinib in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: Cytarabine|DRUG: Daunorubicin Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Nilotinib|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing JNJ-42756493 (Erdafitinib) as Potentially Targeting Treatment in Cancers With FGFR Mutations or Fusions (MATCH - Subprotocol K2)
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Solid Neoplasm
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Erdafitinib|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Diagnosis for Ocular Ischemia Syndrome Using Arterial Spin Labeling Magnetic Resonance Imaging Technique
Status: UNKNOWN
Conditions: Ocular Ischemia Syndrome
Interventions: DIAGNOSTIC_TEST: Arterial spin labeling (ASL) magnetic resonance imaging|DIAGNOSTIC_TEST: Fundus fluorescein angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase II Study of SSGJ-707 Combination Therapy in Advanced NSCLC Patients
Status: RECRUITING
Conditions: First-line Advanced NSCLC Patients
Interventions: DRUG: SSGJ-707|DRUG: carboplatin|DRUG: Pemetrexed|DRUG: paclitaxel|DRUG: PD-1/L1|DRUG: Paclitaxel-albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Virologic Efficacy and Safety of VH3810109 + Cabotegravir Compared to Standard of Care (SOC) in Male and Female Adults Living With Human Immunodeficiency Virus (HIV)
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections
Interventions: BIOLOGICAL: VH3810109|DRUG: Cabotegravir|DRUG: Standard of care (SOC)|BIOLOGICAL: rHuPH20
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rheumatoid Arthritis Treatment and Biopsy Study Assessing Certolizumab Pegol (Cimzia)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Certolizumab Pegol (CZP)|PROCEDURE: Arthroscopic synovial tissue biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Aqua Stand-Up Paddle Balance Effect in Parkinson's Disease (AquaSUP PARK)
Status: COMPLETED
Conditions: Parkinson Disease|Rehabilitation
Interventions: PROCEDURE: Stand-Up Paddle Rehabilitation|PROCEDURE: Physiotherapy Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Short CONSORT Checklist for Peer Reviewers to Improve the Reporting of Randomised Controlled Trials Published
Status: COMPLETED
Conditions: Adequate Reporting in Randomized Controlled Trials
Interventions: OTHER: C-short plus usual practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein
Status: RECRUITING
Conditions: Alpha1-Antitrypsin Deficiency
Interventions: DRUG: Fazirsiran Injection|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "The Effect of Inhaler Lavender, Focus and Music on Women's Pain, Anxiety, in Intrauterine Device Application"
Status: RECRUITING
Conditions: Visual Analog Pain Scale
Interventions: OTHER: inhaled lavender|OTHER: Working Group 2: Focusing|OTHER: Working Group 3 music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dragon Study (the Safety and Efficacy for Treatment of Patients With Complicated Intra Abdominal Infections)
Status: COMPLETED
Conditions: Infection, Intra-abdominal
Interventions: DRUG: Avelox (Moxifloxacin, BAY12-8039)|DRUG: Ceftriaxone + Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Water Drinking Test Response in Supine and Sitting Position Using the Continuous Measurement Device Sensimed Triggerfish Intraocular Pressure in Healthy Subjects
Status: COMPLETED
Conditions: Intraocular Pressure
Interventions: DEVICE: Intraocular pressure measurement with the Sensimed triggerfish Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetics Study of CKD-11101 and NESP After SC Administration in Health Male Volunteers
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: NESP 60μg|DRUG: CKD-11101 60μg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dutch-Depression Outcome Trial Comparing 5 Day Multi Daily Neuronavigated Theta Burst Sessions With 6 Weeks rTMS
Status: RECRUITING
Conditions: Treatment Resistant Depression
Interventions: DEVICE: rTMS|DEVICE: iTBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retrospective Assessment of Adverse Events-related Healthcare Resource Utilization and Costs of Immune Checkpoint Inhibitor and Targeted Therapy for Adjuvant Treatment of Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab + nivolumab|DRUG: Pembrolizumab|DRUG: Dabrafenib + trametinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Styrian Vitamin D Hypertension Trial
Status: COMPLETED
Conditions: Arterial Hypertension|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Periprosthetic Fractures in Hip Fracture Patients: Exeter vs Anatomic SP2 Lubinus Stem
Status: COMPLETED
Conditions: Femoral Neck Fractures|Periprosthetic Fractures
Interventions: PROCEDURE: Exeter stem|PROCEDURE: Lubinus SP2 stem
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of OSA Associated Hypertension With Nebivolol or Hydrochlorothiazide
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Nebivolol|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hybrid Cochlear Implants in Severe to Profound Adults, Children, and Adolescents
Status: COMPLETED
Conditions: Hearing Loss, High-Frequency
Interventions: DEVICE: Cochlear® Nucleus™ Hybrid L24|DEVICE: Cochlear® Nucleus™ Hybrid S12
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial Assessing The Impact Of Inhaled Insulin On Glucose Control In Patients With Type 2 Diabetes Mellitus
Status: TERMINATED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: Inhaled Insulin (Exubera)|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ILM Peeling in PDR Patients Undergoing PPV for VH
Status: COMPLETED
Conditions: Diabetic Retinopathy|Macular Edema
Interventions: PROCEDURE: PPV/MP|PROCEDURE: PPV without MP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Medicated Punctured-Glove-Finger Spacer Study
Status: COMPLETED
Conditions: Sinusitis
Interventions: DRUG: Triamcinolone|OTHER: Saline-impregnated spacer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Virtual Reality on Myocardial Revascularization
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: OTHER: Virtual reality training|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Ipilimumab in Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Leuprolide Acetate|DRUG: Ipilimumab|PROCEDURE: Radical Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Influenza Vaccine Program in Children With Juvenile Idiopathic Arthritis. A Single Centre Results From Hungary
Status: COMPLETED
Conditions: Juvenile Idiopathic Arthritis
Interventions: BIOLOGICAL: Influenza vaccine, Immune function
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Influence of Specific Collagen Peptides on Recovery After Exercise Induced Muscle Damage
Status: COMPLETED
Conditions: Recovery
Interventions: DIETARY_SUPPLEMENT: Collagen|OTHER: Concurrent training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Study Evaluating Nordlys™ SWT IPL for Dry Eye Disease (DED) Due to MGD
Status: RECRUITING
Conditions: Meibomian Gland Dysfunction|Dry Eye Disease
Interventions: DEVICE: Nordlys SWT IPL|PROCEDURE: Meibomian Gland Expression (MGX)|DEVICE: Sham Nordlys SWT IPL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate 608 in Patients With Non- Radiographic Axial Spondyloarthritis (Nr-axSpA)
Status: NOT_YET_RECRUITING
Conditions: Axial Spondyloarthritis
Interventions: DRUG: 608|DRUG: 608|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years
Status: COMPLETED
Conditions: Vasculitis|Wegener's Granulomatosis|Microscopic Polyangiitis|Churg-Strauss Syndrome|Polyarteritis Nodosa
Interventions: DRUG: prednisone, methylprednisolone,cyclophosphamides|DRUG: Cyclophosphamide, Azathioprine,prednisone,methylprednisolone|DRUG: Mycophenolate mofetil,methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Green Tea in Obese Pre-hypertensive Women
Status: COMPLETED
Conditions: Obese|Hypertension
Interventions: DIETARY_SUPPLEMENT: Green Tea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neuromuscular Electrical Stimulation Versus Intermittent Pneumatic Compression for Blood Flow
Status: COMPLETED
Conditions: Venous Thrombosis
Interventions: DEVICE: Neuromuscular Electrical Stimulation|DEVICE: Intermittent Pneumatic Compression
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Tadalafil in Men With Benign Prostatic Hyperplasia (BPH) and Erectile Dysfunction (ED)
Status: COMPLETED
Conditions: Benign Prostate Hyperplasia|Erectile Dysfunction
Interventions: DRUG: 5 mg Tadalafil|DRUG: Placebo|DRUG: 0.2 mg Tamsulosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRESERVED Ejection Fraction Preserved Ejection Fraction
Status: RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction|Heart Failure, Diastolic|Diabetes Mellitus, Type 2|Diabetes Mellitus Type 2 in Obese|Obesity Adult Onset
Interventions: DRUG: Low calorie meal replacement plan|DIAGNOSTIC_TEST: Cardiovascular magnetic resonance (CMR) imaging and magnetic resonance spectroscopy|DIAGNOSTIC_TEST: Transthoracic echocardiography|DIAGNOSTIC_TEST: Blood test|DIAGNOSTIC_TEST: Electrocardiogram|DIAGNOSTIC_TEST: Accelerometery|DIAGNOSTIC_TEST: 6 minute walk test (6MWT)|DIAGNOSTIC_TEST: Skeletal muscle strength using handgrip strength and quadriceps (Cybex dynamometer)|OTHER: Assessment of quality of life and heart failure symptoms|OTHER: Assessment of sarcopenia|OTHER: Assessment of frailty|OTHER: Qualitative interview|DIAGNOSTIC_TEST: Skeletal muscle magnetic resonance spectroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Favipiravir in Covid-19 Patients in Indonesia
Status: COMPLETED
Conditions: Infectious Disease|SARS-CoV Infection|Covid19
Interventions: DRUG: Favipiravir|DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regorafenib and Nivolumab Simultaneous Combination Therapy
Status: COMPLETED
Conditions: Advanced and Metastatic Solid Tumor
Interventions: DRUG: Regorafenib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of CTT1403 for Metastatic Castration Resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: CTT1403|DRUG: CTT1057|DRUG: 68Ga-PSMA-11
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SCLife®-UT hUC-MSCs Advanced Therapy Medicinal Products (hUC-MSCs ATMPs) for Patients With Thin Endometrial Infertility
Status: RECRUITING
Conditions: Infertility, Female
Interventions: BIOLOGICAL: human umbilical cord mesenchymal stem cell complex collagen|PROCEDURE: intrauterine injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Haploidentical Natural Killer Cell Infusions for Poor Prognosis Non-AML Hematologic Malignancies
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Chronic Myelogenous Leukemia|Juvenile Myelomonocytic Leukemia|Myelodysplastic Syndrome|Non-Hodgkin's Lymphoma
Interventions: OTHER: NK Cell Infusion|BIOLOGICAL: Immunotherapy|DEVICE: Miltenyi Biotec CliniMACS device|DRUG: Interleukin-2 (IL-2)|DRUG: Clofarabine|DRUG: Cyclophosphamide|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BCD Regimen in Newly Diagnosed Idiopathic Multicentric Castleman's Disease (iMCD)
Status: UNKNOWN
Conditions: Idiopathic Multicentric Castleman's Disease
Interventions: DRUG: Bortezomib|DRUG: Cyclophosphamide|DRUG: Dexamethason
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blood Pressure in Dialysis Patients
Status: COMPLETED
Conditions: Hypertension|Renal Failure Chronic Requiring Hemodialysis|Blood Pressure|Dialysis
Interventions: DRUG: Antihypertensive Agents|OTHER: Dry weight Challenge|DIETARY_SUPPLEMENT: Extend dialysis treatment time and re-challenge estimated dry weight
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Dose Risperidone Consta for Patients With Schizophrenia With Poor Response to Risperidone
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: long-acting injectable risperidone|DRUG: long acting injectable risperidone|DRUG: long acting injectable risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: asparaginase|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: dexamethasone|DRUG: leucovorin calcium|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: thioguanine|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TQB3454 Tablets in Patients With Blood Tumors
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: TQB3454 Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D3 Supplementation in Children From 12 to 30 Months of Age.
Status: COMPLETED
Conditions: Vitamin D Deficiency|25-Hydroxyvitamin D3 Deficiency, Selective
Interventions: DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Primary Care dySpEpsia rikkuNshiTo
Status: NOT_YET_RECRUITING
Conditions: Dyspepsia and Other Specified Disorders of Function of Stomach|Postprandial Distress Syndrome
Interventions: DRUG: Rikkunshi-to|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: UCDCC#269: A Pilot Study of Interlesional IL-2 and RT in Patients With NSCLC.
Status: COMPLETED
Conditions: METASTATIC NON-SMALL CELL LUNG CANCER
Interventions: DRUG: Intralesional IL-2|DRUG: Nivolumab|DRUG: Pembrolizumab|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ixekizumab in Participants With Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Drug Cocktail|DRUG: Ixekizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Autologous Bone Marrow Derived Mononuclear Cells for Treatment of Ebstein Anomaly
Status: COMPLETED
Conditions: Ebstein Anomaly
Interventions: BIOLOGICAL: Autologous Bone Marrow-derived Mononuclear Cells|DEVICE: Insertable cardiac monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Lymphoplasmacytic Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoplasmacytic Lymphoma
Interventions: BIOLOGICAL: Autologous Lymphoma Immunoglobulin-derived scFv-chemokine DNA Vaccine|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Early Immunologic Response in Asian Patients With Chronic Hepatitis B, Treated With Pegasys (Peginterferon Alfa-2a (40KD)), Nucleoside Analogues, or Both
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: peginterferon alfa-2a [Pegasys]|DRUG: tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of the NeuroSENSE for Monitoring the Hypnotic Depth of Anesthesia
Status: COMPLETED
Conditions: Depth of Anesthesia (DOA)
Interventions: DRUG: Propofol induction followed by randomized doses of desflurane|DEVICE: Recording of EEG using NeuroSENSE|OTHER: Data collection|OTHER: Drug: Emergence by stepping down the desflurane ET
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mi-STITCH™ and Mi-KNOT™ Device Technologies - Improvement of Mitral Valve Repair
Status: UNKNOWN
Conditions: Mitral Regurgitation|Mitral Valve Insufficiency
Interventions: DEVICE: Mi-Chord™ Device Technologies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cadaveric Islet Transplantation in Patients With Insulin-Dependent Diabetes Mellitus
Status: TERMINATED
Conditions: Islets of Langerhans Transplantation|Diabetes Mellitus, Type 1
Interventions: DRUG: Islets of Langerhans
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Guided Narrative Technique on Child Post-traumatic Stress Symptoms Related to Teachers' Improper Criticism
Status: COMPLETED
Conditions: Posttraumatic Stress Symptoms
Interventions: BEHAVIORAL: guided narrative technique-writing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Azithromycin as an Adjunct to Scaling and Root Planning in the Treatment of Periodontitis
Status: COMPLETED
Conditions: Periodontitis
Interventions: DRUG: Az+SRP|DRUG: SRP|DRUG: No interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of an Experimental Gel Based on Copaiba Oil Resin in Reducing Post-bleaching Tooth Sensitivity
Status: COMPLETED
Conditions: Tooth Bleaching Pain
Interventions: OTHER: GCO (Experimental copaiba oil resin gel)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cytokine Adsorption in Patients With Severe COVID-19 Pneumonia Requiring Extracorporeal Membrane Oxygenation
Status: SUSPENDED
Conditions: Coronavirus Infection|COVID|SARS-CoV 2|Respiratory Failure|Cytokine Storm|Extracorporeal Membrane Oxygenation
Interventions: DEVICE: vv-ECMO + cytokine adsorption (Cytosorb adsorber)|DEVICE: vv-ECMO only (no cytokine adsorption)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Effects of BT With Moderate Intensity Aerobic Versus RT in Type 2 DM.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: BALANCE TRAINING WITH MODERATE INTESITY AEROBIC VERSUS RESISTED TRAINING (RT)|OTHER: Moderate intensity resistance exercises in combination with balance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Justice-Involved Veterans and Moral Reconation Therapy
Status: COMPLETED
Conditions: Antisocial Personality Disorder|Substance Use Disorder
Interventions: BEHAVIORAL: Moral Reconation Therapy (MRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-Label Study of Long-Term Safety and Efficacy of Intravenous Trappsol Cyclo (HPβCD) in Niemann-Pick Disease Type C
Status: UNKNOWN
Conditions: Niemann-Pick Disease, Type C1
Interventions: DRUG: Hydroxypropyl-β-cyclodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Tazemetostat as Single Agent in Solid Tumors or B-cell Lymphomas and in Combination With Prednisolone in DLBCL
Status: COMPLETED
Conditions: B-cell Lymphomas (Phase 1)|Advanced Solid Tumors (Phase 1)|Diffuse Large B-cell Lymphoma (Phase 2)|Follicular Lymphoma (Phase 2)|Transformed Follicular Lymphoma|Primary Mediastinal Large B-Cell Lymphoma
Interventions: DRUG: Tazemetostat|DRUG: Prednisolone|DRUG: Tazemetostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritional Intervention for Age-related Muscular Function and Strength Losses-Study 2
Status: COMPLETED
Conditions: Sarcopenia
Interventions: DIETARY_SUPPLEMENT: Placebo|DRUG: HMB plus Vitamin D|BEHAVIORAL: Non-Exercise|BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Monovalent Pandemic H5N1 Vaccine in Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza A (H5N1) Virus Monovalent Vaccine, Adjuvanted
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Study of SL19+22 CAR-T Cells for Relapsed or Refractory Non-Hodgkin Lymphoma
Status: UNKNOWN
Conditions: Non-hodgkin's Lymphoma
Interventions: BIOLOGICAL: CD19+22 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Iron Deficiency Anemia in Malaria Endemic Ghana
Status: COMPLETED
Conditions: Anemia
Interventions: DIETARY_SUPPLEMENT: Sprinkles®|DIETARY_SUPPLEMENT: vitamin/mineral fortificant without iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma
Status: NOT_YET_RECRUITING
Conditions: Plasma Cell Myeloma Refractory
Interventions: DRUG: Isatuximab SC-OBDS|DRUG: Montelukast|DRUG: Dexamethasone|DRUG: Acetaminophen|DRUG: Diphenhydramine|DRUG: Methylprednisolone|DRUG: Carfilzomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Celecoxib With or Without Eflornithine in Preventing Colorectal Cancer in Patients With Familial Adenomatous Polyposis
Status: COMPLETED
Conditions: Colorectal Cancer|Familial Adenomatous Polyposis
Interventions: DRUG: Celecoxib|OTHER: Placebo|DRUG: eflornithine|OTHER: Laboratory biomarker analysis|OTHER: Questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Conventional or Unconventional Lymph Node Dissection During Resection of Intrahepatic Cholangiocarcinoma
Status: UNKNOWN
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: PROCEDURE: conventional lymph node dissection|PROCEDURE: unconventional lymph node dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of Administering Lidocaine Spray in Oesophago-gastro-duodenoscopy
Status: COMPLETED
Conditions: Tolerance
Interventions: DRUG: Lidocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Alcohol Consumption on the Success Rates
Status: RECRUITING
Conditions: Pulpitis - Irreversible
Interventions: DRUG: Lidocaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of PRF Application on Clinical Parameters and GCF Platelet-derived Growth Factor-BB and Periostin Levels
Status: COMPLETED
Conditions: Periodontitis
Interventions: OTHER: Platelet rich fibrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: EAGLET: EEG vs aEEG to Improve the Diagnosis of neonataL Seizures and Epilepsy
Status: RECRUITING
Conditions: Neonatal Seizures
Interventions: DIAGNOSTIC_TEST: Group B: aEEG with concurrent multichannel (full) continuous cEEG review by clinical neurophysiology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Combined Mirtazapine and SSRI Treatment of PTSD: A Placebo-Controlled Trial
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: Mirtazapine|DRUG: Sertraline|OTHER: Sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Micro-transplantation in Elderly Patients With Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: OTHER: HLA-mismatched micro-transplantation after induction chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Italian Multicentric Study on the Treatment of Visceral Aneurysms With the Flow Diversion Stent Derivo Peripher and Derivo 2
Status: NOT_YET_RECRUITING
Conditions: Aneurysm Abdominal|Arterial Aneurysm
Interventions: DEVICE: Visceral aneurysm stenting
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Acupuncture in Reducing Chemotherapy-Induced Peripheral Neuropathy in Participants With Stage I-III Breast Cancer
Status: COMPLETED
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Grade 1 Peripheral Motor Neuropathy, CTCAE|Grade 1 Peripheral Sensory Neuropathy, CTCAE|Grade 2 Peripheral Motor Neuropathy, CTCAE|Grade 2 Peripheral Sensory Neuropathy, CTCAE|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8
Interventions: PROCEDURE: Acupuncture Therapy|OTHER: Best Practice|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Transcranial Magnetic Stimulation and/or Neurofunctional Electrical Acupuncture in Myofascial Chronic Pain Patients
Status: UNKNOWN
Conditions: Myofascial Pain Syndromes
Interventions: DEVICE: Active rTMS|DEVICE: Sham rTMS|DEVICE: Active Neuroacupuncture|DEVICE: Sham Neuroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Spinal Stabilization Exercises Vs Maitland Mobilization Along With Laser Therapy
Status: UNKNOWN
Conditions: Low Back Ache
Interventions: BEHAVIORAL: Spinal Stabilization Exercises|BEHAVIORAL: Maitland Mobilization Along With Laser Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Staple-line Reinforcement During Laparoscopic Sleeve Gastrectomy Using Three Different Techniques: a Randomized Trial
Status: COMPLETED
Conditions: Complication of Surgical Procedure|Leak; Blood
Interventions: PROCEDURE: Bariatric surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving the Iron Status of Athletes With Pre-, Pro- and Synbiotics
Status: COMPLETED
Conditions: Iron-deficiency|Iron Deficiency Anemia|Iron Deficiency (Without Anemia)
Interventions: DIETARY_SUPPLEMENT: Partially hydrolyzed guar gum + bifidobacterium lactis|DIETARY_SUPPLEMENT: Partially hydrolyzed guar gum|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RNS System NAUTILUS Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Epilepsy|Idiopathic Generalized Epilepsy|Generalized Tonic Clonic Seizure
Interventions: DEVICE: Responsive stimulation|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Biomarker Study for Sunitinib and Docetaxel in Prostate Cancer
Status: UNKNOWN
Conditions: Hormone Refractory Prostate Cancer
Interventions: DRUG: Docetaxel * Sunitinib|DRUG: Docetaxel|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Added Fruit Pomace Fiber, Juice, and Whole Fruit on Postprandial Glycemia
Status: COMPLETED
Conditions: Glycemic Index
Interventions: OTHER: Fruit|OTHER: Fruit juice|OTHER: Fruit juice plus fiber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Phase III Trial With Docetaxel Plus Epirubicine Versus Docetaxel Plus Capecitabine for Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Docetaxel|DRUG: Capecitabine|DRUG: Epirubicin|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A New Fast DWI-based MR Protocol for Surveillance in Patients With a High Risk of Ovarian Cancer Recurrence During PARP-inhibitors Maintenance to Enhance Secondary Cytoreduction Results
Status: NOT_YET_RECRUITING
Conditions: Ovarian Cancer|Recurrent Ovarian Carcinoma
Interventions: OTHER: Magnetic resonance imaging as fpr clinical practice
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combined Treatment With Alteplase (Rt-PA) and Cerebrolysin® in Acute Ischemic Hemispheric Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: Cerebrolysin|DRUG: 0.9% Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT