pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Double-Blind, Randomized, Active-Comparator (Metformin) Controlled, Clinical Trial to Study the Efficacy and Safety of the Strategy to Start Patients With Type 2 Diabetes Mellitus on Janumet™ Compared to Metformin
Status: UNKNOWN
Conditions: Diabetes Type 2
Interventions: DRUG: Metformin 1500 mg daily|DRUG: Metformin + Janufer (Janumet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase Ib/II Study of Fluzoparib in Combination With Dalpiciclib in Patients With Locally Advanced or Metastatic Sarcoma
Status: RECRUITING
Conditions: Sarcoma
Interventions: DRUG: Fluzoparib+ Dalpiciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of BP1001 (L-Grb-2 Antisense Oligonucleotide) in CML, AML, ALL & MDS
Status: COMPLETED
Conditions: Recurrent Adult Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Myelodysplastic Syndrome|Ph1 Positive CML
Interventions: DRUG: BP1001|DRUG: BP1001 in combination with LDAC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of IONIS-ENaCRx in Healthy Volunteers and Patients With Cystic Fibrosis
Status: COMPLETED
Conditions: Healthy Subjects|Cystic Fibrosis
Interventions: DRUG: IONIS-ENaCRx|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Apixaban in Patients Undergoing Pancreaticoduodenectomy
Status: COMPLETED
Conditions: Pancreas Cancer|DVT|Pulmonary Embolism
Interventions: DRUG: Apixaban
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Performance of Two Contact Lenses Compared to a Marketed Lens
Status: COMPLETED
Conditions: Refractive Ametropia
Interventions: DEVICE: etafilcon A control lens (1DM)|DEVICE: etafilcon A with print and PVP for light eyes (EALE)|DEVICE: etafilcon A with print and PVP for dark eyes (EADE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Long-Term Safety, Tolerability, & Efficacy of BMN 111 in Children With Achondroplasia (ACH)
Status: ACTIVE_NOT_RECRUITING
Conditions: Achondroplasia
Interventions: DRUG: BMN 111
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation and Expansion Study of Lomvastomig, a PD-1/TIM-3 Bispecific Antibody, in Participants With Advanced and/or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors|Metastatic Melanoma|Non-small Cell Lung Cancer (NSCLC)|Small Cell Lung Cancer (SCLC)|Esophageal Squamous Cell Carcinoma (ESCC)
Interventions: DRUG: Lomvastomig
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HRT on Overactive Bladder Symptoms, Sexual Function, Depressive Symptoms, Autonomic Function, and Arterial Stiffness
Status: RECRUITING
Conditions: Menopausal Syndrome
Interventions: DRUG: Tibolone 2.5 mg|DRUG: Estradiol valerate 1 mg/medroxyprogesterone acetate 2.5 mg
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Electrical Stimulation With Interferential Current in the Non-especific Chronic Low Back Pain: Effects on the Autonomic Nervous System.
Status: COMPLETED
Conditions: Chronic Low-back Pain|Chronic Pain|Autonomic Imbalance
Interventions: DEVICE: Electrical stimulation: Interferential Current (IFC): Experimental Group|DEVICE: Electrical stimulation: Interferential Current (IFC): Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination Chemotherapy and Bevacizumab in Treating Patients With Stage IV Colon Cancer That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: fluorouracil|DRUG: leucovorin|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Therapy Mediated by Topical Application of 5- ALA for the Treatment of Actinic Keratoses
Status: WITHDRAWN
Conditions: Actinic Keratosis
Interventions: DRUG: 5-ALA plus Blu-Light|DRUG: 5-FU, Imiquimod or treatment with cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare the Effect of a Remote Monitoring System Using the EXACT Tool to Reduce Hospitalizations Due to Chronic Obstructive Pulmonary Disease (COPD) Exacerbations. EXACT = Exacerbations of Chronic Pulmonary Disease Tool.
Status: COMPLETED
Conditions: Remote Patient Monitoring in COPD Patients
Interventions: DEVICE: Remote Patient Monitoring|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ergocalciferol Therapy in Calcidiol Deficient, Hemodialysis Patients on Therapeutic Doses of Paricalcitol
Status: COMPLETED
Conditions: Inflammation|Insulin Resistance
Interventions: DRUG: Ergocalciferol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Correlation Between the Quantitative Parameters of Mr Mean Cell Size Imaging and the Histopathological Characteristics of Breast Cancer
Status: UNKNOWN
Conditions: Breast Carcinoma; Magnetic Resonance Imaging；OGSE
Interventions: DIAGNOSTIC_TEST: Gradient and pulse imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Volume Spirometry and Deep Breathing Exercise for Dyspnea During Third Trimester of Pregnancy
Status: COMPLETED
Conditions: Dyspnea|Pregnancy Related
Interventions: OTHER: Conventional treatment|OTHER: conventional treatment with volume Spirometry and deep breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paradoxical Tuberculosis Immune Reconstitution Inflammatory Syndrome (TB-IRIS) Treatment Trial
Status: WITHDRAWN
Conditions: Immune Reconstitution Inflammatory Syndrome|Immune Reconstitution Syndrome|Tuberculosis|HIV-infection/Aids
Interventions: DRUG: Dexamethasone|DRUG: Atorvastatin|DRUG: Naproxen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antioxidants Vitamins and Muscle Damage
Status: COMPLETED
Conditions: Oxidative Stress
Interventions: DIETARY_SUPPLEMENT: Dietary Supplement: Vitamin C and vitamin E|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of ASP1941 in Japanese Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: ipragliflozin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ozurdex Monotherapy Trial
Status: RECRUITING
Conditions: Uveitis, Posterior|Uveitis, Intermediate|Panuveitis
Interventions: DRUG: Ozurdex 0.7mg Ophthalmic Implant|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for the Immune System in Radiation Cancer Patients
Status: WITHDRAWN
Conditions: Gastrointestinal Neoplasms|Urogenital Neoplasms
Interventions: PROCEDURE: Medical Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Obeldesivir in Nonhospitalized Participants With COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Obeldesivir|DRUG: Obeldesivir Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Boussignac CPAP Ventilation on PaO2 and PaO2/FiO2 Ratio in Morbidly Obese Patients Undergoing Bariatric Surgery
Status: COMPLETED
Conditions: Morbid Obesity
Interventions: DEVICE: Boussignac CPAP|DEVICE: Venturi face mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of a FimH Blocker, EB8018, in Crohn's Disease Patients
Status: COMPLETED
Conditions: Crohn Disease
Interventions: DRUG: EB8018 (First-in-class FimH blocker)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Early Cancer Detection in People at High Risk of Developing Pancreatic Ductal Adenocarcinoma (PDAC)
Status: RECRUITING
Conditions: Pancreatic Cyst
Interventions: DIAGNOSTIC_TEST: 89Zr-DFO-HuMab-5B1 immunoPET|DIAGNOSTIC_TEST: HP MRI|COMBINATION_PRODUCT: Blood assay
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mental Health in Refugees and Asylum Seekers
Status: COMPLETED
Conditions: Affective Disorders
Interventions: BEHAVIORAL: Peer-to-Peer-Groupintervention|BEHAVIORAL: Smartphone-based-Intervention|BEHAVIORAL: Gendersensitive-Groupintervention|BEHAVIORAL: Empowerment-Groupintervention|BEHAVIORAL: Adolescent-Groupintervention|OTHER: Treatment as Ususal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mesh Fixation and Closure of Peritoneum Following Laparoscopic Hernia Repair Using N-butyl Cyanoacrylate
Status: COMPLETED
Conditions: Hernia, Inguinal
Interventions: DEVICE: LiquiBandFix8
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Tadalafil Combined With LIPUS for Treating Erectile Dysfunction
Status: NOT_YET_RECRUITING
Conditions: Erectile Dysfunction
Interventions: DRUG: Tadalafil 5mg|DEVICE: LIPUS (Low Intensity Pulsed Ultrasound)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: XIENCE V/PROMUS Everolimus-Eluting Stent System Post-marketing Surveillance Protocol for Japan
Status: COMPLETED
Conditions: Angina|Chronic Coronary Occlusion|Stent Thrombosis|Vascular Disease|Myocardial Ischemia|Coronary Artery Stenosis|Coronary Disease|Coronary Artery Disease|Coronary Restenosis
Interventions: DEVICE: XIENCE V / PROMUS stent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Improving Quality With Outpatient Decision Support
Status: COMPLETED
Conditions: Diabetes Mellitus|Coronary Artery Disease|Osteoporosis|Hypertension|Hyperlipidemia
Interventions: BEHAVIORAL: Computerized Reminders Medications Monitoring|BEHAVIORAL: Computerized Test Results Management Application|BEHAVIORAL: Computerized Reminders Hypertension Management|BEHAVIORAL: Computerized Reminders Osteoporosis Screening and Mgt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Magnetic Therapy and Moderate Aerobic Exercise on Post Thyroidectomy Osteoporosis
Status: COMPLETED
Conditions: Osteoporosis
Interventions: OTHER: patients received the routine medical treatment in addition to pulsed magnetic therapy and moderate-intensity aerobic exercise for 12 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Exercise Training on Gait and Quality of Life in Parkinson's Disease
Status: TERMINATED
Conditions: Parkinson's Disease
Interventions: OTHER: Walking on treadmill|OTHER: Walking on treadmill|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Factors Determining the Efficacy of Botulinum Toxin for Arm Tremor in Dystonia
Status: NOT_YET_RECRUITING
Conditions: Dystonic Tremor Syndrome|Dystonia|Tremor
Interventions: DIAGNOSTIC_TEST: Polymyography|DIAGNOSTIC_TEST: Muscle ultrasound|DIAGNOSTIC_TEST: (Functional) magnetic resonance imaging|DIAGNOSTIC_TEST: Clinical assessment|DIAGNOSTIC_TEST: Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sleep-Disordered Breathing in Chronic SCI
Status: COMPLETED
Conditions: Spinal Cord Injury|Sleep Apnea, Obstructive
Interventions: DEVICE: AutoPAP|DEVICE: Sham PAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiorespiratory Effects of Nasal High Frequency Ventilation in Neonates
Status: COMPLETED
Conditions: Ventilator Lung; Newborn|Hemodynamic Instability|Echocardiography
Interventions: DEVICE: NHFOV|DEVICE: NCPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Aspirin Or Warfarin To Prevent Stroke
Status: TERMINATED
Conditions: Stroke|Cerebral Infarction|Atherosclerosis|Constriction, Pathologic
Interventions: DRUG: Warfarin|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: WILSTIM - DBS (WILson STIMulation - Deep Brain Stimulation)
Status: COMPLETED
Conditions: Severe Dystonia|Wilson's Disease
Interventions: DEVICE: Medtronic, Activa® PC "on"|DEVICE: Medtronic, Activa® PC "off"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Shinbaro Pharmacopuncture in Sciatic Pain Patients With Lumbar Disc Herniation
Status: COMPLETED
Conditions: Sciatica|Intervertebral Disc Displacement
Interventions: PROCEDURE: Shinbaro pharmacopuncture|DEVICE: Acupuncture|DRUG: Conventional medicine|PROCEDURE: Physical therapy|BEHAVIORAL: Educational program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nicotinamide Riboside in Hospitalized Patients
Status: COMPLETED
Conditions: Inflammation|Acute Illness
Interventions: DRUG: Nicotinamide riboside|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Biological Efficacy of Clopidogrel After Implantation of Drug-eluting Stents (SPACE)
Status: COMPLETED
Conditions: Coronary Artery Disease|Atherosclerosis|Diabetes Mellitus|Metabolic Syndrome X
Interventions: PROCEDURE: blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluating the Efficacy and Safety of Fulvestrant Plus DNA Damage Repair Inhibitors After a CDK4/6 Inhibitor
Status: NOT_YET_RECRUITING
Conditions: Advanced Breast Cancer
Interventions: DRUG: Olaparib|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of CGA for Frail Elderly Patients Operated for Colorectal Cancer - The CRC Frailty-study
Status: RECRUITING
Conditions: Colorectal Neoplasms|Frailty|CGA
Interventions: OTHER: Comprehensive geriatric assessment (CGA) and care|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hepatic IA Therapy in Stage B or Limited Stage C Hepatoma (HCC)
Status: RECRUITING
Conditions: Hepatocellular Carcinoma (HCC)
Interventions: BIOLOGICAL: IA therapy of HCC with CSR02-Fab-TF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibogaine in the Treatment of Alcoholism: a Randomized, Double-blind, Placebo-controlled, Escalating-dose, Phase 2 Trial
Status: ENROLLING_BY_INVITATION
Conditions: Alcoholism
Interventions: DRUG: Ibogaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Combination of PIGEV Before Autologous Stem Cell Transplant in Patients With Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: Hodgkin's Lymphoma
Interventions: DRUG: panobinostat|DRUG: Ifosfamide|DRUG: Gemcitabine|DRUG: Vinorelbine|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab and Interleukin-2 in Treating Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: HER2-positive Breast Cancer|Male Breast Cancer|Recurrent Breast Cancer|Stage IV Breast Cancer
Interventions: BIOLOGICAL: trastuzumab|BIOLOGICAL: aldesleukin|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EktoTherix™ Regenerative Tissue Scaffold for Repair of Surgical Excision Wounds
Status: COMPLETED
Conditions: Non-melanoma Skin Cancer|Basal Cell Carcinoma|Squamous Cell Carcinoma
Interventions: DEVICE: EktoTherix
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rasburicase in Patients at Risk for Tumor Lysis Syndrome
Status: COMPLETED
Conditions: Tumor Lysis Syndrome
Interventions: DRUG: As Needed Rasburicase|DRUG: Fixed Dose Rasburicase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial of Phonological Interventions
Status: UNKNOWN
Conditions: Speech Articulation Disorder|Developmental Articulation Disorder|Phonological Impairment|Dyslexia
Interventions: BEHAVIORAL: Speech Production Intervention|BEHAVIORAL: Speech Perception Intervention|BEHAVIORAL: Articulation Parent Group|BEHAVIORAL: Dialogic Reading Parent Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Trial of Pulse Dyed Laser (Chromogenex Regenlite Transform) in the Treatment of Inflammatory Acne Vulgaris
Status: WITHDRAWN
Conditions: Acne Vulgaris
Interventions: DEVICE: Chromogenix Regenlite Transform Treatment|DEVICE: Chromogenix Regenlite Transform Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Performance of the Journey™ II UNI Unicompartmental Knee System
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-inflammatory Degenerative Joint Disease (NIDJD) of the Knee
Interventions: DEVICE: Journey™ II UNI Unicompartmental Knee System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Endometrial Advancement After Rec or u-HCG Triggering
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: 10000 IU urinary HCG|DRUG: 250 mcg recombinant HCG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Methotrexate Use Improvement in Rheumatoid Arthritis Using Biomarker Feedback
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: OTHER: Drug level blood tests|OTHER: Telephone Interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of CFZ533 in Type 1 Diabetes Pediatric and Young Adult Subjects
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: CFZ533|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Arthroscopic Debridement vs Arthroscopic Hemi-Trapeziectomy on Patients With Thumb Carpometacarpal Joint Osteoarthritis
Status: UNKNOWN
Conditions: Osteoarthritis Thumb
Interventions: PROCEDURE: Arthroscopic Debridement|PROCEDURE: Arthroscopic Hemi-Trapeziectomy with Mini TightRope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Effectiveness of Aceclidine/Brimonidine (LNZ101) and Aceclidine (LNZ100) in the Treatment of Presbyopia
Status: COMPLETED
Conditions: Presbyopia|Refractive Errors|Eye Diseases
Interventions: DRUG: Aceclidine+Brimonidine combination ophthalmic solution|DRUG: Aceclidine ophthalmic solution|DRUG: Vehicle Proprietary Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rituximab, Cyclophosphamide, Bortezomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Low-Grade Follicular Lymphoma, Waldenstrom Macroglobulinemia, or Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue|Nodal Marginal Zone Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Splenic Marginal Zone Lymphoma|Waldenstrom Macroglobulinemia
Interventions: DRUG: Bortezomib|BIOLOGICAL: Rituximab|DRUG: Cyclophosphamide|DRUG: Dexamethasone|OTHER: Questionnaire Administration|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Effect of Pulsed Electromagnetic Field on Quadriceps Muscle Strength After Burn Injury
Status: UNKNOWN
Conditions: Lower Limb Burn
Interventions: DEVICE: pulsed electromagnetic field device|OTHER: Free weights for Strengthening Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Subanesthetic Dose Esketamine on Propofol-refentanil Closed-loop Targeted Controlled Infusion
Status: NOT_YET_RECRUITING
Conditions: Esketamine
Interventions: DRUG: Subanesthetic dose of esketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of COVI-VAC, a Live Attenuated Vaccine Against COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: COVI-VAC|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: NUYou:mHealth Intervention to Preserve and Promote Ideal Cardiovascular Health
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: BEHAVIORAL: Mobile Health Application|BEHAVIORAL: Environmental Cues|BEHAVIORAL: Social Support|BEHAVIORAL: Educational Materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sintilimab and Chemotherapy Sequential Radiotherapy in Advanced Esophageal Cancer
Status: RECRUITING
Conditions: Metastatic Esophageal Squamous Cell Carcinoma
Interventions: DRUG: TP regimen (cis-platinum ; Tocetaxel ) combined with PD-1 inhibitors（Sintilimab）
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 PEP- High-risk Individuals in Long-term and Specialized Care - Canada
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Hydroxychloroquine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TRENDY Follow-up: Study on Endothelial Function in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Telmisartan 80 mg/d|DRUG: Ramipril 10 mg/d
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation
Status: COMPLETED
Conditions: Bone Marrow Failure Syndrome|Thalassemia|Sickle Cell Disease|Diamond Blackfan Anemia|Acquired Neutropenia in Newborn|Acquired Anemia Hemolytic|Acquired Thrombocytopenia|Hemophagocytic Lymphohistiocytoses|Wiskott-Aldrich Syndrome|Chronic Granulomatous Disease|Common Variable Immunodeficiency|X-linked Lymphoproliferative Disease|Severe Combined Immunodeficiency|Hurler Syndrome|Mannosidosis|Adrenoleukodystrophy
Interventions: DRUG: Thiotepa--single daily dose|DRUG: Thiotepa--escalated dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pediatric Liver Transplantation-Liver Fibrosis Evaluation by Using Fibrosis Panel
Status: RECRUITING
Conditions: Liver Fibrosis|Pediatric Disorder|Liver Transplant; Complications
Interventions: DIAGNOSTIC_TEST: Liver Allograft Fibrosis by Using Fibrosis Panel(PRO-C3, PIIINP, TIMP-1, HA etc.)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Rifaximin Treatment of Papulopustular Rosacea
Status: WITHDRAWN
Conditions: Rosacea
Interventions: DRUG: Rifaximin (XIFAXAN)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Aliskiren and Valsartan as a Single Tablet vs. the Same Doses of the Two Drugs Given Separately to Healthy Subjects.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Aliskiren|DRUG: Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RSV-MVA-BN Vaccine Phase I Trial, Intranasal Application in Adults.
Status: WITHDRAWN
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: MVA-BN-RSV|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Short-time High-intensity Interval Training on Tissue Glucose and Fat Metabolism in Healthy Subjects and Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus|Healthy Volunteers
Interventions: BEHAVIORAL: HIT exercise intervention|BEHAVIORAL: Aerobic exercise intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Mobile Health Technology for Personalized Tobacco Cessation Support in Laos
Status: RECRUITING
Conditions: Cigarette Smoking
Interventions: DRUG: Nicotine patch|BEHAVIORAL: Self-help materials (to support smoking cessation)|BEHAVIORAL: Smartphone-based automated treatment for smoking cessation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Erenumab-aooe for the Management of Trigeminal Neuropathic Pain.
Status: TERMINATED
Conditions: Trigeminal Neuropathy
Interventions: DRUG: Erenumab-Aooe|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Of The Blood Thinner, Apixaban, For Patients Who Have An Abnormal Heart Rhythm (Atrial Fibrillation) And Expected To Have Treatment To Put Them Back Into A Normal Heart Rhythm (Cardioversion)
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Apixaban|DRUG: Parenteral heparin and/or oral Vitamin K antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SUN11031 in Cachexia Associated With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Cachexia
Interventions: DRUG: Placebo comparator|DRUG: SUN11031 20 μg/kg|DRUG: SUN11031 40 μg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Evaluating the Efficacy and Safety of AGB101 for Treatment of Parkinson's Disease Related Psychosis
Status: RECRUITING
Conditions: Parkinson Disease Psychosis
Interventions: DRUG: AGB101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of GlaxoSmithKline (GSK)1557484A Vaccine in Adults at Occupational Risk for Influenza A (H5N1) Exposure
Status: COMPLETED
Conditions: Influenza|Influenza Vaccines
Interventions: BIOLOGICAL: Influenza A (H5N1) Virus Monovalent Vaccine, Adjuvanted (A/Indonesia)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: TCb vs EC-T in High Risk ER+/HER2- Breast Cancer
Status: RECRUITING
Conditions: Hormone Receptor Positive HER-2 Negative Breast Cancer
Interventions: DRUG: Docetaxel|DRUG: Carboplatin|DRUG: Epirubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Examine Safety and Immune Responses of GSK 257049 Vaccine When Administered to Infants Living in a Malaria-endemic Region
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: RTS,S/AS02D|BIOLOGICAL: TETRActHib™|BIOLOGICAL: Engerix-B®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating Clinical Routines for ICBT
Status: RECRUITING
Conditions: Depression|Panic Disorder|Social Anxiety Disorder
Interventions: BEHAVIORAL: Internet-based Cognitive Behavioural Therapy (iCBT) with Decision Support Tool|BEHAVIORAL: Internet-based Cognitive Behavioural Therapy (iCBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Could Non-invasive Biochemical, Image or Physiological Index Predict Significant Coronary Arterial Stenosis in Symptomatic Adults?
Status: UNKNOWN
Conditions: Coronary Heart Disease
Interventions: RADIATION: coronary calcium score measurement|BIOLOGICAL: high sensitivity C reactive protein measurement|PROCEDURE: ankle brachial index measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: S0902 Bendamustine and Rituximab in Treating Patients With B-Cell Chronic Lymphocytic Leukemia That Has Not Responded to Previous Treatment
Status: WITHDRAWN
Conditions: Leukemia
Interventions: BIOLOGICAL: rituximab|DRUG: bendamustine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Transnasal Humidified Rapid-insufflation Ventilatory Exchange (THRIVE) for Maternal Pre-oxygenation
Status: COMPLETED
Conditions: Cesarean Section Complications|Pregnancy Related|Anesthesia
Interventions: PROCEDURE: scenario 1 : pre-oxygenation with a face mask held by the anaesthetist|PROCEDURE: scenario 2: one anaesthetist in charge, face mask held by the patient for pre-oxygenation|PROCEDURE: scenario 3: one anaesthetist in charge, THRIVE used for pre-oxygenation|PROCEDURE: scenario 4: one anaesthetist and one nurse anaesthetist in charge, the face mask is held by the anaesthetist or the nurse anaesthetist
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Videolaryngoscopy for Intubation in Patients With Diabetes
Status: COMPLETED
Conditions: Anesthesia|Diabetes Mellitus|Intubation;Difficult|Videolaryngoscopy
Interventions: DEVICE: Videolaryngoscopy|DEVICE: laringoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Intra-Operative Intracapsular Blocks in Post-Operative Pain Management Following Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: OTHER: Placebo saline injection|DRUG: Ropivicaine 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Alisertib (MLN8237) in Participants With Ovarian, Fallopian Tube or Peritoneal Cancer Preceded by Phase 1 Study of MLN8237 Plus Paclitaxel Treatment of Ovary or Breast Cancer
Status: COMPLETED
Conditions: Ovarian Carcinoma|Fallopian Tube Cancer|Peritoneal Cancer|Breast Carcinoma
Interventions: DRUG: Alisertib|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Cancer-anorexia Using Megestrol Acetate Concentrated Suspension in Lung or Pancreatic Cancer Patients
Status: TERMINATED
Conditions: Anorexia|Cachexia|Weight Loss
Interventions: DRUG: Megestrol acetate concentrated suspension 110 mg/mL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Single and Multiple Doses of KW-6356 in Healthy Subjects
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: KW-6356 Low Dose|DRUG: KW-6356 Middle Dose|DRUG: KW-6356 High Dose|DRUG: KW-6356 X Dose|DRUG: KW-6356 Y Dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Haloperidol for Pain Control in Patients With Acute Musculoskeletal Back Pain in the Emergency Department
Status: RECRUITING
Conditions: Back Pain|Chronic Pain
Interventions: DRUG: Haloperidol|DRUG: Ketorolac Tromethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rectal Misoprostol in Women Undergoing Total Abdominal Hysterectomy for Intraoperative Blood Loss Reduction
Status: COMPLETED
Conditions: Intraoperative Blood Loss
Interventions: DRUG: Rectal misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of LY3337641 in Rheumatoid Arthritis
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: LY3337641|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Colorectal Polyps Screening With Low-dose CT Colonoscopy
Status: UNKNOWN
Conditions: Polyps|Colorectal Neoplasm
Interventions: RADIATION: CT colonoscopy(normal dose)|RADIATION: CT colonoscopy (low dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: Leukemia|Lymphoma
Interventions: DRUG: asparaginase|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: leucovorin calcium|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: methylprednisolone|DRUG: mitoxantrone hydrochloride|DRUG: prednisolone|DRUG: therapeutic hydrocortisone|DRUG: thioguanine|DRUG: vincristine sulfate|DRUG: vindesine|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Performance of LuX-Valve Plus System for Tricuspid Replacement
Status: RECRUITING
Conditions: Tricuspid Regurgitation
Interventions: DEVICE: Transcatheter Tricuspid Valve Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REmodelling in Diabetic CardiOmapathy: Gender Response to PDE5i InhibiTOrs
Status: COMPLETED
Conditions: Diabetic Cardiomyopathy|Diabetes Mellitus Type 2
Interventions: DRUG: Tadalafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modeling and Pharmacological Targeting of Genetic Cardiomyopathy in Children Via Cardiomyocytes Derived From Induced Pluripotent Stem Cells (DMDstem)
Status: COMPLETED
Conditions: Cardiomyopathy, Familial
Interventions: OTHER: Electrocardiogram|OTHER: physical examination|OTHER: echocardiography|BIOLOGICAL: blood test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bortezomib in Treating Patients With Multiple Myeloma Who Have Undergone an Autologous Peripheral Blood Stem Cell Transplant
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Scoring Clinical Index For Onychomycosis in Toenail Onychomycosis Treating With Itraconazole Capsules
Status: COMPLETED
Conditions: Onychomycosis, Toe
Interventions: DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of the Swallow Expansion Device (SED) for Improvement of Swallowing in Patients
Status: TERMINATED
Conditions: Oropharyngeal Dysphagia (OPD)|Dysphagia
Interventions: DEVICE: Swallowing Expansion Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Two Different Cervical Collars for the Treatment in Patient With Cervical Radiculopathy and Radicular Pain
Status: UNKNOWN
Conditions: Cervical Radiculopathy|Radicular Pain|Acute Neck Pain|Cervicobrachial Pain
Interventions: OTHER: FIR cervical collar with Acetaminophen|OTHER: Conservative cervical collar with Acetaminophen|DRUG: Acetaminophen only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of N-acetylcysteine Versus Placebo Efficacy in the Cannabis Withdrawal
Status: TERMINATED
Conditions: Cannabis Dependence|Cannabis Abuse
Interventions: DRUG: N-acetylcystein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Essential Amino Acids and Protein Kinetics During Caloric Deprivation
Status: COMPLETED
Conditions: Muscle Protein Synthesis|Whole-body Protein Balance
Interventions: DIETARY_SUPPLEMENT: Standard EAA|DIETARY_SUPPLEMENT: High EAA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Comparing Arthrodesis Technique of Thoracic and/or Lumbar Spine by Posterior Approach Performed by Robot-assisted Surgery (Robot Mazor X Stealth ™) Versus Conventional Surgery
Status: RECRUITING
Conditions: Osteosynthesis|Mazor Robot|Spinal Surgery|Arthrosis; Spine
Interventions: PROCEDURE: Computerised tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FOCUSau: A Dyadic Digital Health Intervention to Improve the Wellbeing of People With Advanced Cancer and Their Carers
Status: NOT_YET_RECRUITING
Conditions: Advanced Cancer
Interventions: BEHAVIORAL: FOCUSau
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Remotely-Delivered Benefits Counseling for Service Connection Applicants
Status: COMPLETED
Conditions: Job Satisfaction|Unemployment
Interventions: BEHAVIORAL: Remotely-Delivered Benefits Counseling|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 177Lu-PSMA-617 vs. Androgen Receptor-directed Therapy in the Treatment of Progressive Metastatic Castrate Resistant Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostatic Neoplasms
Interventions: DRUG: 177Lu-PSMA-617|DRUG: 68Ga-PSMA-11|DRUG: ARDT|OTHER: Best supportive care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Flex-It Stylet to Malleable Stylet for GlideScope Intubation: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Intubation
Interventions: DEVICE: Flex-It Stylet|DEVICE: Standard malleable stylet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Fatty Acids For Treatment Of Young Children With Autism (OMG)
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DIETARY_SUPPLEMENT: Omega-3 Fatty Acids|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Individualized Respiratory Exercise Device in Healthy Individuals
Status: RECRUITING
Conditions: Healthy
Interventions: DEVICE: Individualized Respiratory Exercise Device|DEVICE: Threshold® IMT + Threshold™ PEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Photobiomodulation on Major Salivary Glands in Children With Caries Activity
Status: RECRUITING
Conditions: Caries,Dental
Interventions: DEVICE: Photobiomodulation|DEVICE: Photobiomodulation- Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Methadone Patient Access to Collaborative Treatment
Status: NOT_YET_RECRUITING
Conditions: Opioid Substitution Treatment Clinics|Patients|Staff
Interventions: OTHER: MPACT Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Investigating Multimodally Endothelial Dysfunction in Ocular and Systemic Disease
Status: RECRUITING
Conditions: Kidney Diseases|Diastolic Heart Failure|Small Vessel Disease|Glaucoma
Interventions: DIAGNOSTIC_TEST: Optical coherence tomography(-angiography) OCT(A)|DIAGNOSTIC_TEST: Fundus pictures|DIAGNOSTIC_TEST: DVA 3.0|DIAGNOSTIC_TEST: Hyperspectral retinal images|DIAGNOSTIC_TEST: SphygmoCor|DIAGNOSTIC_TEST: Sphygmomanometer|DIAGNOSTIC_TEST: Blood sample|DIAGNOSTIC_TEST: Skin biopsy|DIAGNOSTIC_TEST: Neuropsychological examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Can Levothyroxine Treatment Reduce the Development of Cardio-metabolic Disorder in Subclinical Hypothyroidism?
Status: UNKNOWN
Conditions: Subclinical hypothyroïdism
Interventions: DRUG: Levothyroxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: S1916 Digital Medicine Program for Pain Control in Cancer Patients
Status: TERMINATED
Conditions: Metastatic Cancer
Interventions: DRUG: Oxycodone/acetaminophen 5/325 mg|DEVICE: Proteus digital medicine program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE