pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Low-Glycemic Index Mediterranean Diet on AGEs
Status: COMPLETED
Conditions: Type 2 Diabetes|Insulin Resistance|Obesity|Cardiovascular Disease
Interventions: BEHAVIORAL: Low Glycemic Index Mediterranean Diet|OTHER: INRAM Guidelines' diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Shugan Dingtong Decoction in the Treatment of Fibromyalgia
Status: UNKNOWN
Conditions: Fibromyalgia
Interventions: DRUG: Shugan Dingtong decoction|DRUG: Duloxetine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single and Repeated Dose Escalation of RBD1016 in Subjects With Chronic Hepatitis B Virus (HBV) Infection
Status: COMPLETED
Conditions: Chronic Hepatitis b
Interventions: DRUG: RBD1016|DRUG: Placebo|DRUG: Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness and Psychedelics
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: DMT + harmine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Sacituzumab Govitecan (IMMU-132) in Endometrial Carcinoma
Status: RECRUITING
Conditions: Endometrial Carcinoma
Interventions: DRUG: Sacituzumab Govitecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Outcomes of Femoral Derotation Osteotomy for Individuals With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy|Femoral Derotation Osteotomy|Outcomes
Interventions: DIAGNOSTIC_TEST: Motion Analysis|DIAGNOSTIC_TEST: sterEOS Imaging of Lower Extremities|BEHAVIORAL: Surveys
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SOLFA Study to Explore the Thrombogenicity of a Dialyzer
Status: COMPLETED
Conditions: End Stage Renal Disease on Dialysis
Interventions: DEVICE: Compared the trombogenicity of the Solacea dialyzer with synthetic dialyzers after progressively decreasing heparin until discontinuing it
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Behavioral Activation: An Intervention for Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder|MDD|Depression
Interventions: DEVICE: Virtual Reality Behavioral Activation|BEHAVIORAL: Behavioral Activation in real-life
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ipack Block and Surgeon's Joint Infiltration in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteo Arthritis Knee
Interventions: DEVICE: Ipack|DRUG: Bupivacaine|PROCEDURE: Peri Articular Infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation Of Class I Composite Resin Restorations Using Three Different Adhesive Systems
Status: COMPLETED
Conditions: Dental Adhesive Materials
Interventions: OTHER: Dental adhesive materials.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Manual Techniques in Cervicogenic Headache
Status: COMPLETED
Conditions: Cervicogenic Headache
Interventions: OTHER: Deep Neck Flexor Massage|OTHER: Post-Isometric Relaxation Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Response to Magnesium Sulfate as an Adjunct in the Anesthesia
Status: RECRUITING
Conditions: Anesthesia and Analgesia|Magnesium Sulfate
Interventions: DRUG: Perioperative magnesium sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase II, Randomized, Double-blind, Placebo-controlled Study to Assess MEDI3506 in Participants With COPD and Chronic Bronchitis
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)|Chronic Bronchitis
Interventions: BIOLOGICAL: MEDI3506|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gossypol Acetic Acid in Treating Patients With Recurrent, Metastatic, or Primary Adrenocortical Cancer That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Recurrent Adrenocortical Carcinoma|Stage III Adrenocortical Carcinoma|Stage IV Adrenocortical Carcinoma
Interventions: DRUG: R-(-)-gossypol acetic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Recombinant Human Relaxin (rhRlx) in Compensated Congestive Heart Failure
Status: COMPLETED
Conditions: Heart Failure, Congestive
Interventions: DRUG: Relaxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Efficacy of ATS907 in Subjects With Primary Open Angle Glaucoma (POAG) and Ocular Hypertension
Status: UNKNOWN
Conditions: Primary Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Stage 1 - ATS907 - Dose 1|DRUG: Stage 1 - ATS907 - Dose 2|DRUG: Stage 1 - ATS907 - Dose 3|DRUG: Stage 1 - ATS907 - Dose 4|DRUG: Stage 1 - Vehicle|DRUG: Stage 2 - ATS907 - Dose A - to be selected based on Stage 1|DRUG: Stage 2 - ATS907 - Dose B - to be selected based on Stage 1|DRUG: Timoptic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nephroureterectomy With and Without Lymph Node Dissection for Upper Tract Urothelial Cell Carcinoma
Status: RECRUITING
Conditions: Urothelial Carcinoma
Interventions: PROCEDURE: Nephroureterectomy|PROCEDURE: Lymph Node Dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Bone Marrow Mononuclear Cell Implantation for Moderate to Severe Peripheral Arterial Disease
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: PROCEDURE: Bone marrow mononuclear cell implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azithromycin in Hospitalized COVID-19 Patients
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Hydroxychloroquine|DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Local Analgesia With Epinephrine During Total Hip Arthroplasty (THA)
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Hip
Interventions: DRUG: ropivacaine, physical serum and adrenalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dynamic Quantification of Social-Visual Engagement in Autism Spectrum Disorder (ASD) For Children Ages 31-84 Months
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Autism
Interventions: DEVICE: EarliPoint Diagnosis|BEHAVIORAL: Clinically Certain Expert Clinician Diagnosis (CC-ECD)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Optimal Balloon Catheter Placement During Sonohysterography
Status: COMPLETED
Conditions: Infertility
Interventions: DEVICE: sonohysterography with inflated catheter in uterine cavity|DEVICE: sonohysterography with inflated catheter in cervical cavity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Adjuvant Liquid Alginate on Endoscopic Ablation Therapy of Complicated Barrett's Esophagus
Status: COMPLETED
Conditions: Barretts Esophagus With Dysplasia
Interventions: DRUG: Alginates
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Examining How a Facilitated Self-Sampling Intervention and Testing Navigation Intervention Influences COVID-19 Testing
Status: NOT_YET_RECRUITING
Conditions: COVID-19
Interventions: BEHAVIORAL: Facilitated Self-Sampling Intervention (FSSI)|BEHAVIORAL: Testing Navigation Intervention (TNI).|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bioequivalence Study for Donepezil Hydrochloride Tablets 10 mg Under Fed Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Donepezil Hydrochloride|DRUG: Aricept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Standard Issue Transfusion Versus Fresher Red Blood Cell Use in Intensive Care- A Randomised Controlled Trial
Status: COMPLETED
Conditions: Transfusion|Age of Blood
Interventions: OTHER: Blood transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Pharmacokinetics and Pharmacodynamics of Canagliflozin in Healthy Chinese Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Treatment A: Canagliflozin 100 mg|DRUG: Treatment B: Canagliflozin 300 mg|OTHER: Treatment C: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Branched Chain Amino Acids for Hepatic Encephalopathy in ACLF
Status: COMPLETED
Conditions: Hepatic Encephalopathy|Acute-On-Chronic Liver Failure
Interventions: DRUG: Branched chain amino acid|DRUG: Lactulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Titanium Reinforced d-PTFE Membrane Versus Collagen Membrane For Guided Bone Regeneration
Status: RECRUITING
Conditions: Alveolar Ridge Enlargement
Interventions: DEVICE: collagen membrane (Creos Xenoprotect , Nobel Biocare AB, Göteborg, Sweden)|DEVICE: titanium reinforced d-PTFE membrane (Creos Syntoprotect , Nobel Biocare AB, Göteborg, Sweden)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Transitional Cerebrovascular Reactivity in Very Preterm Infants
Status: COMPLETED
Conditions: Cerebral Autoregulation|Preterm Birth|Premature Infant Disease
Interventions: DEVICE: Near Infrared Spectroscopy monitoring|DEVICE: Electrical velocimetry and pulse oximetry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adoptive Transfer of Specific Melanoma Antigens CD8+ T Cells in Metastatic Melanoma Patients: a Phase I/II Study
Status: COMPLETED
Conditions: Metastatic Melanoma
Interventions: BIOLOGICAL: Melanoma antigens-specific CD8+ T lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Automated Intracytoplasmic Sperm Injection (ICSIA)
Status: ACTIVE_NOT_RECRUITING
Conditions: Infertility, Female
Interventions: DEVICE: Investigational device named ICSIA|DEVICE: Manual ICSI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Strength Testing After Nitrate Delivery (STAND) in ICU Patients
Status: COMPLETED
Conditions: Respiratory Failure
Interventions: DIETARY_SUPPLEMENT: Nitrate Rich Beetroot Juice|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid in Surgery of Advanced Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Tranexamic acid|DRUG: 0.9% NaCl solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sugars-containing Beverage and Food Intake in Children
Status: COMPLETED
Conditions: Childhood Obesity
Interventions: DIETARY_SUPPLEMENT: water with Sucralose|DIETARY_SUPPLEMENT: water with HFCS|DIETARY_SUPPLEMENT: water with glucose|DIETARY_SUPPLEMENT: water with sucrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Phase 2 Study of Hemay007 in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Hemay007 800 mg QD group|DRUG: Hemay007 1200 mg QD group|DRUG: Hemay007 600 mg QD group|DRUG: Hemay007 placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Randomized Controlled Trial for a Rapid Pleurodesis Protocol for the Management of Pleural Effusions
Status: COMPLETED
Conditions: Malignant Pleural Effusions
Interventions: OTHER: Thoracoscopy and Pleurx|PROCEDURE: Thoracoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PfSPZ Vaccine: Dose Optimization With Heterologous Challenge in Healthy Malaria-Naïve Adults
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: PfSPZ Vaccine|BIOLOGICAL: CHMI (7G8)|BIOLOGICAL: CHMI (NF135.C10)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate Safety, Tolerability and Efficacy of UCB7665 in Subjects With Primary Immune Thrombocytopenia
Status: COMPLETED
Conditions: Thrombocytopenia
Interventions: DRUG: UCB7665
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Some Drugs Used in Treatment of Vasculitis on the Complement System in Children
Status: UNKNOWN
Conditions: Vasculitis
Interventions: DRUG: Ibuprofen|DRUG: Prednisone|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Electroacupuncture at Different Acupoints on Bladder Function After Spinal Cord Injury
Status: UNKNOWN
Conditions: Neurogenic Bladder
Interventions: OTHER: electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Multisensory Stimulation Virtual Reality for Stroke Patients.
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: DEVICE: multi-sensory stimulation immersive VR+ treadmill training|DEVICE: treadmill training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Traditional Chinese Medicine Combined With Entecavir to Treat Refractory Liver Fibrosis in Liver Cirrhosis Due to HBV
Status: UNKNOWN
Conditions: Hepatitis B Virus Related Cirrhosis
Interventions: DRUG: Entecavir+Fuzheng Huayu+TCM Granule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Lucitanib in Combination With Nivolumab in Patients With a Solid Tumor
Status: SUSPENDED
Conditions: Advanced Solid Tumor|Gynecologic Cancer
Interventions: DRUG: Lucitanib|DRUG: Lucitanib|DRUG: Lucitanib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Extension Study for Subjects With H1 Antihistamine Refractory Chronic Spontaneous Urticaria Completing Study AK006-001
Status: ENROLLING_BY_INVITATION
Conditions: Chronic Spontaneous Urticaria
Interventions: DRUG: AK006 IV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of NSAID Use on Pain and Opioid Consumption Following Distal Radius Fracture
Status: TERMINATED
Conditions: Distal Radius Fracture
Interventions: DRUG: Ibuprofen|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Subfascial Approach in Thyroidectomy to Quality of Life in Thyroid Disease Patients
Status: COMPLETED
Conditions: Thyroid Cancer
Interventions: PROCEDURE: subfascial flap|PROCEDURE: subplatysmal flap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Visualization of Inspiratory Effort and Respiratory Mechanics to Promote Lung- and Diaphragm Protective Ventilation
Status: UNKNOWN
Conditions: Respiratory Muscles|Respiration, Artificial|Respiratory Function Tests
Interventions: DEVICE: Placement of nasogastric balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of TNF-Inhibition Combined With Conventional DMARDs on Cervical Pannus in Patients With RA and Cervical Spine Involvement
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: therapy with disease-modifying anti rheumatic drugs (DMARD)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Toripalimab Plus FLOT in Locally Advanced Gastric Cancer
Status: RECRUITING
Conditions: Chemotherapy|Immune Checkpoint Inhibitor|Locally Advanced Gastric Carcinoma
Interventions: DRUG: FLOT combined with toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability and Efficacy Study of TransCon hGH in Children With Growth Hormone Deficiency
Status: COMPLETED
Conditions: Growth Hormone Deficiency, Pediatric|Endocrine System Diseases|Hormone Deficiency|Pituitary Diseases
Interventions: DRUG: TransCon hGH
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of IV Lidocaine at Alleviating Pain Associated With Propofol Infusion in Pediatric Patients Undergoing Sedation
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: normal saline|DRUG: lidocaine|DRUG: lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CHILD (Child Health and Infection With Low Density) Malaria
Status: ACTIVE_NOT_RECRUITING
Conditions: Malaria,Falciparum|Malaria
Interventions: OTHER: Active case detection using molecular testing (ACDm)|OTHER: Passive case detection using molecular testing (PCDm)|OTHER: Control (standard of care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Comparison of pCLE Based Targeted Biopsy and WLE Based Standard Biopsy in Staging the Operative Link on Gastric Intestinal Metaplasia (OLGIM): A Randomized，Cross-over Study
Status: UNKNOWN
Conditions: Gastric Intestinal Metaplasia|Confocal Laser Endomicroscopy|Operative Link on Gastric Intestinal Metaplasia|Biopsy
Interventions: DEVICE: Patients in Group 1 will receive pCLE at first and WLE 2 months later|DEVICE: patients in Group 2 will receive WLE at first and pCLE 2 months later.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Pharmacokinetics and Cardiac Properties of Elacytarabine (CP-4055)
Status: COMPLETED
Conditions: Relapsed/Refractory AML
Interventions: DRUG: Elacytarabine for infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Intra-articular Dexmedetomidine and Magnesium in Postoperative Pain
Status: COMPLETED
Conditions: Postoperative Pain|Intra-articular Injection|Dexmedetomidine|Magnesium Sulfate
Interventions: DRUG: Precedex|DRUG: Magnesium Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of a New Predictive Test of Preterm Birth in Case of Threatened Preterm Labor
Status: UNKNOWN
Conditions: Threatened Preterm Labor|Preterm Delivery
Interventions: DEVICE: Premaquick®|DEVICE: PARTOSURE®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Follow-up Trial to Assess the Long-term Safety and Tolerability of Talsaclidine in Patients With Mild to Moderate Dementia of the Alzheimer Type
Status: TERMINATED
Conditions: Alzheimer Disease
Interventions: DRUG: Talsaclidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Efficacy of Free-opioid Anesthesia for Colorectal Surgery
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: PROCEDURE: Free-opioid anesthesia|PROCEDURE: opioid anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Against Chemotherapy in Stomach Cancer or Stomach/Esophagus Junction Cancer
Status: COMPLETED
Conditions: Gastric Cancer|Gastroesophageal Junction Cancer|Esophageal Adenocarcinoma
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Leucovorin|DRUG: Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy and Safety of AMAG-423 (Digoxin Immune Fab) in Antepartum Subjects With Severe Preeclampsia
Status: TERMINATED
Conditions: Severe Preeclampsia
Interventions: BIOLOGICAL: AMAG-423 (digoxin immune fab)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RELIEF-pathway in Patients With Upper Abdominal Pain
Status: NOT_YET_RECRUITING
Conditions: Abdominal Pain|Gallstone; Colic|Dyspepsia|Irritable Bowel Syndrome|Health Care Utilization|Patient Reported Outcomes|Upper Abdominal Pain|Decision Aid
Interventions: OTHER: RELIEF-pathway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TXA Study in Major Burn Surgery
Status: TERMINATED
Conditions: Tranexamic Acid|Burn|Major Surgery
Interventions: DRUG: Tranexamic Acid|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Hypoglycaemic Regimens During Ramadan Fasting in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes, Type 2
Interventions: DRUG: Acarbose|OTHER: Diet and lifestyle|DRUG: Metformin|DRUG: Metformin/ Glimepride|DRUG: Metformin/Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fibroblast Growth Factor Regeneration of Tympanic Membrane Perforations
Status: COMPLETED
Conditions: Tympanic Membrane Perforation
Interventions: DRUG: FGF-2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Heel Distraction Height on Foot Loading With Carbon Fiber Custom Dynamic Orthoses
Status: RECRUITING
Conditions: Traumatic Lower Limb Injury
Interventions: DEVICE: Carbon Fiber Custom Dynamic Orthosis (CDO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Clinical Trial of Efficacy, Safety, and Immunogenicity of Gam-COVID-Vac Vaccine Against COVID-19 in Belarus
Status: UNKNOWN
Conditions: Covid19
Interventions: BIOLOGICAL: Gam-COVID-Vac|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Long-term Efficacy and Safety of Subjects Approximately 3 Years After Priming With 2 Doses of GSK Bio's HRV Vaccine.
Status: COMPLETED
Conditions: Infections, Rotavirus
Interventions: BIOLOGICAL: Rotarix (primary vaccination study)|BIOLOGICAL: Placebo (primary vaccination study)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy, Safety and Pharmacokinetics of QAV680 in Asthma Patients
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: QAV680|DRUG: Matching placebo for QAV680|DRUG: Fluticasone Propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Pharmacology of GDC-0980 in Combination With Either Paclitaxel and Carboplatin (With or Without Bevacizumab) or Pemetrexed and Cisplatin in Patients With Solid Tumors
Status: COMPLETED
Conditions: Solid Cancers
Interventions: DRUG: GDC-0980|DRUG: bevacizumab|DRUG: carboplatin|DRUG: cisplatin|DRUG: paclitaxel|DRUG: pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addressing Unmet Social Needs Among Hospitalized Children
Status: NOT_YET_RECRUITING
Conditions: Social Needs Screening|Caregiver-care Team Relationships|Social Needs Status|Child Health Status|Caregiver Health Status|Utilization, Health Care
Interventions: OTHER: Social needs screening protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lorcaserin in Combination With XR-Naltrexone for Relapse Prevention in Opioid Use Disorder
Status: COMPLETED
Conditions: Opioid-use Disorder
Interventions: DRUG: Lorcaserin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2a ID93 + GLA-SE Vaccine Trial in TB Patients After Treatment Completion
Status: COMPLETED
Conditions: Pulmonary Tuberculosis
Interventions: OTHER: Placebo|BIOLOGICAL: ID93 + GLA-SE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tapentadol Prolonged Release (PR) Versus Oxycodone/Naloxone Prolonged Release in Severe Chronic Low Back Pain With a Neuropathic Component.
Status: COMPLETED
Conditions: Back Pain|Low Back Pain|Neuropathic Pain
Interventions: DRUG: Tapentadol Prolonged Release|DRUG: Oxycodone/Naloxone Prolonged Release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selective Use of Episiotomy: the Impact on Perineal Trauma.
Status: COMPLETED
Conditions: Perineal Tear|Episiotomy Wound|Delivery; Injury, Maternal
Interventions: OTHER: Classification of perineal tears based on new classification|PROCEDURE: Selective use of Episiotomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose-Ranging Study of Quadrivalent Human Papillomavirus (HPV) (Types 6,11,16,18) L1 Virus-Like Particle (VLP) Vaccine (V501-007)(COMPLETED)
Status: COMPLETED
Conditions: Papillomavirus Infections|Genital Diseases, Female
Interventions: BIOLOGICAL: Quadrivalent HPV (Types 6,11,16,18) L1 VLP Vaccine 20/40/40/20|BIOLOGICAL: Quadrivalent HPV (Types 6,11,16,18) L1 VLP Vaccine 40/40/40/40|BIOLOGICAL: Quadrivalent HPV (Types 6,11,16,18) L1 VLP Vaccine 80/80/40/80|BIOLOGICAL: Placebo (mcg) (Aluminum Adjuvant)225|BIOLOGICAL: Placebo (mcg) (Aluminum Adjuvant) 450
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Efficacy and Safety of Unimodal Bilateral Flexible Ureteroscopy.
Status: RECRUITING
Conditions: Kidney Stone
Interventions: PROCEDURE: Bilateral same-session flexible ureterorenoscopy|PROCEDURE: Unilateral same-session flexible ureterorenoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Study of the Effects of Navarixin (SCH 527123, MK-7123) in Participants With Moderate to Severe COPD (MK-7123-019)
Status: TERMINATED
Conditions: COPD
Interventions: DRUG: Navarixin|DRUG: Placebo|DRUG: Rescue medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine and CT-011 for Resected Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Neoplasms|Cancer of the Pancreas|Neoplasms Pancreatic|Pancreatic Cancer|Pancreas Cancer
Interventions: BIOLOGICAL: CT-011|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autogenous Particles Harvesting During Implant Surgery
Status: NOT_YET_RECRUITING
Conditions: Dental Implant Failed
Interventions: PROCEDURE: Low speed drilling without irrigation|PROCEDURE: High speed drilling with irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ellagic Acid, Urolithin and Colonic Microbial Communities Affected by Walnut Consumption
Status: COMPLETED
Conditions: Colo-rectal Cancer|Colon Cancer|Diet Habit
Interventions: OTHER: Walnuts
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety of 3 New 6:2 Influenza Virus Reassortants in Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Trivalent Influenza Virus Vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety Study of AMG 228 to Treat Solid Tumors
Status: TERMINATED
Conditions: Advanced Malignancy|Advanced Solid Tumors|Cancer|Oncology|Oncology Patients|Tumors|Melanoma|Non-small Cell Lung Cancer|Squamous Cell Carcinoma of the Head and Neck|Transitional Cell Carinoma of Bladder|Colorectal Cancer
Interventions: DRUG: AMG 228
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intralesional PRP in Treatment of Onychomycosis
Status: UNKNOWN
Conditions: Platelet Rich Plasma
Interventions: BIOLOGICAL: intralesional platelet rich plasma|DRUG: Oral terbinafine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Dexamethasone and Its Effect on Hyperglycemia
Status: WITHDRAWN
Conditions: Diabetes Mellitus
Interventions: DRUG: Dexamethasone|OTHER: No dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Plasma Copeptin Levels in Children With Diabetic Ketoacidosis
Status: COMPLETED
Conditions: Diabetic Ketoacidosis Children
Interventions: OTHER: Copeptine dosage in children with diabetic ketoacidosis at diagnosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Zilovertamab Vedotin (MK-2140/VLS-101) in Participants With Solid Tumors (MK-2140-002)
Status: TERMINATED
Conditions: Triple-negative Breast Cancer|Non-squamous Non-small-cell Lung Cancer|NSCLC|Estrogen-receptor-positive Breast Cancer|Progesterone-receptor-positive Breast Cancer|Estrogen-receptor-negative Breast Cancer|ER-negative Breast Cancer|Progesterone-receptor Negative Breast Cancer|PR-negative Breast Cancer|HER2-negative Breast Cancer|ER-positive Breast Cancer|PR-positive Breast Cancer|Platinum-resistant Ovarian Cancer|Gastric Cancer|Pancreatic Cancer
Interventions: DRUG: Zilovertamab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Extension Study to Determine Safety and Efficacy for Pediatric Patients With MPS Type IIIA Disease Who Participated in Study HGT-SAN-093.
Status: TERMINATED
Conditions: Sanfilippo Syndrome|Mucopolysaccharidosis (MPS)
Interventions: DRUG: HGT-1410
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Inflammation on Reward Circuits, Motivational Deficits and Negative Symptoms in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: OTHER: Oral Glucose Tolerance Test (OGTT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Study of Atezolizumab (Anti-PD-L1) and Sipuleucel-T in Patients With Asymptomatic or Minimally Symptomatic Metastatic Castrate Resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer Metastatic
Interventions: DRUG: Atezolizumab1200 mg IV|DRUG: Sipuleucel-T
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The ED95 Dose of Sugammadex to Reverse Rocuronium-Induced Deep Neuromuscular Block Back to Shallow Neuromuscular Block
Status: NOT_YET_RECRUITING
Conditions: Deep Neuromuscular Blockade|Anesthesia, General
Interventions: DRUG: Sugammadex
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Bioequivalence Study of Two Sunitinib Products in Capsules 50 mg in Healthy Volunteers Under Fasting Conditions
Status: UNKNOWN
Conditions: Bioequivalence
Interventions: DRUG: Aviga, capsules 50 mg / Sutent®, capsules 50 mg|DRUG: Sutent®, capsules 50 mg / Aviga, capsules 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: TEACO: Taxotere, Eloxatin, Avastin in Cancer of the Ovary
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Bevacizumab (Avastin®)|DRUG: Docetaxel (Taxotere®)|DRUG: Oxaliplatin (Eloxatin®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study for the Development of an Activity and Quality of Life Questionnaire for the Follow-up of Patients With Non-dystrophic Myotonia
Status: NOT_YET_RECRUITING
Conditions: Non-Dystrophic Myotonia
Interventions: OTHER: Questionnaire for Non-dystrophic myotonias
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Hypertonic Saline-hetastarch in Cardiac Surgery
Status: COMPLETED
Conditions: Postoperative Cardiorespiratory Failure
Interventions: DRUG: Hypertonic saline (7.2%) hetastarch (6 %)(200/0.5)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of Umbilical Cord Blood-Drived Mesenchymal Stem Cells to Promote Engraftment of Unrelated Hematopoietic Stem Cell Transplantation
Status: COMPLETED
Conditions: Acute Leukemia
Interventions: BIOLOGICAL: Human umbilical cord blood-derived mesenchymal stem cells|BIOLOGICAL: Human umbilical cord blood-derived mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Inhaled Insulin Compared With Subcutaneous Human Insulin Therapy in Adults With Type 2 Diabetes
Status: TERMINATED
Conditions: Diabetes Mellitus
Interventions: DRUG: Inhaled Insulin|DRUG: Subcutaneous insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hamate Hook Removal, Microscrew Internal Fixation and Plaster Fixation for the Treatment of Hamate Hook Fractures
Status: COMPLETED
Conditions: Fractures, Bone
Interventions: PROCEDURE: hamate hook removal|PROCEDURE: microscrew internal fixation|OTHER: short-arm tube-type plaster fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Follow-up Trial to Evaluate Long-term Safety and Efficacy of Brivaracetam in Subjects Suffering From Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Brivaracetam (ucb 34714)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of nanOss Cervical IBF System to C-Plus PEEK IBF Device With Autograft
Status: COMPLETED
Conditions: Intervertebral Disc Degeneration
Interventions: DEVICE: nanOss|DEVICE: C-Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Romidepsin and the Therapeutic Vaccine Vacc-4x for Reduction of the Latent HIV-1 Reservoir
Status: COMPLETED
Conditions: HIV I Infection
Interventions: DRUG: Romidepsin|BIOLOGICAL: Vacc-4x|BIOLOGICAL: rhuGM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Self-management Program to Prevent Falls in People With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: fall prevention program|OTHER: Brochure about falls and fall risk factors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Gender Difference in Response to Caffeine in Children and Adolescents
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Placebo Administration first|DRUG: Low Caffeine Administration first (1mg/kg body weight)|DRUG: High Caffeine Administration first (2mg/kg body weight)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Isatuximab and Cemiplimab in Relapsed or Refractory Natural Killer/T-cell Lymphoid Malignancy
Status: RECRUITING
Conditions: Natural Killer/T-cell Lymphoma|Relapsed Natural Killer/T-cell Lymphoma|Refractory Natural Killer/T-cell Lymphoma
Interventions: DRUG: Isatuximab|DRUG: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Loratadine for the Prevention of G-CSF-related Bone Pain
Status: NOT_YET_RECRUITING
Conditions: Stem Cell Transplant Complications
Interventions: DRUG: Loratadine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Reliability of Function Tests for People With Back Pain.
Status: COMPLETED
Conditions: Low Back Pain|Adult
Interventions: DIAGNOSTIC_TEST: 6-minute walk test|DIAGNOSTIC_TEST: 10 meters walk test|DIAGNOSTIC_TEST: 30 Second Sit to Stand Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Cognitive Function in Postmenopausal Women With Breast Cancer Receiving Hormone Therapy on Clinical Trial IBCSG-1-98
Status: COMPLETED
Conditions: Breast Cancer|Cognitive/Functional Effects|Fatigue|Psychosocial Effects of Cancer and Its Treatment
Interventions: PROCEDURE: cognitive assessment|PROCEDURE: fatigue assessment and management|PROCEDURE: psychologic distress|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Renal Sympathetic Denervation on Resistant Hypertension and Cardiovascular Hemodynamic in Comparison to Intensive Medical Therapy Utilizing Impedance Cardiography
Status: UNKNOWN
Conditions: Hypertension, Resistant to Conventional Therapy
Interventions: PROCEDURE: The SymplicityTM Renal Denervation System|DEVICE: The HOTMAN® System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Probiotic Supplementation on Mental Health in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy|Stress-related Problem|Depression|Anxiety
Interventions: DIETARY_SUPPLEMENT: Lactobacillus helveticus R0052 and Bifidobacterium longum R0175|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tight Glycemic Control With Intensive Insulin Therapy in PICU
Status: UNKNOWN
Conditions: Critical Illness
Interventions: DRUG: intensive insulin therapy (Actrapid IV to normoglycemia)|DRUG: conventional insulin therapy (Actrapid IV only for excessive hyperglycemia)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Sovilnesib in Subjects With Ovarian Cancer
Status: RECRUITING
Conditions: High Grade Serous Adenocarcinoma of Ovary|Fallopian Tube Cancer|Primary Peritoneal Carcinoma|Chromosomal Instability
Interventions: DRUG: Sovilnesib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sabatolimab as a Treatment for Patients With Acute Myeloid Leukemia and Presence of Measurable Residual Disease After Allogeneic Stem Cell Transplantation.
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: Sabatolimab|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability and Pharmacokinetics of GSK2339345.
Status: COMPLETED
Conditions: Cough
Interventions: DRUG: GSK2339345 (Inhaled) Single Dose|OTHER: Placebo (Inhaled) Single Dose|DRUG: GSK2339345 (Inhaled) Repeat Dose|OTHER: Placebo (Inhaled) Repeat Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endurant Evo US Clinical Trial
Status: TERMINATED
Conditions: Abdominal Aortic Aneurysm|AAA
Interventions: DEVICE: Endurant Evo AAA Stent Graft System|PROCEDURE: Endovascular aneurysm repair (EVAR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Multi-focal tDCS on Motor-cognitive Dysfunctions in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: DEVICE: Active tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Doctor-patient Communication on Treatment Expectation, Placebo and Nocebo Response
Status: UNKNOWN
Conditions: Healthy Participants
Interventions: OTHER: medical consultation: different doctor-patient-centered style of communication|OTHER: information letter / no medical consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Transcranial Direct Current Stimulation (tDCS) on Post-stroke Patients on Neuromotor Recovery
Status: RECRUITING
Conditions: Stroke
Interventions: DEVICE: tDCS|OTHER: Conventional rehabilitative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IL-12 Gene and in Vivo Electroporation-Mediated Plasmid DNA Vaccine Therapy in Patients With Merkel Cell Cancer
Status: COMPLETED
Conditions: Merkel Cell Carcinoma
Interventions: BIOLOGICAL: Tavokinogene Telseplasmid (tavo)|DEVICE: OncoSec Medical System (OMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT