pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Randomized Trial to Improve Quality of Life Outcomes in Asthma Patients
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: Enhance asthma knowledge, self-efficacy, social support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Pilot Study Evaluate the Safety and Efficacy of Sirolimus in Patients With PIK3CA Mutation and/or PIK3CA Amplification Refractory Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient-Controlled Thoracic Paravertebral Block After Video-Assisted Thoracoscopic Surgery
Status: UNKNOWN
Conditions: Video-assisted Thoracoscopic Surgery
Interventions: PROCEDURE: Continuous paravertebral analgesia (C-PVB)|PROCEDURE: Patient-controlled paravertebral analgesia (PC-PVB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VERARE : Effectiveness of Virtual Motor Actions for Improving Walking in Patients With Post-resuscitation Muscle Weakness
Status: WITHDRAWN
Conditions: Weakness of the Lower Limbs
Interventions: OTHER: Observation of Virtual Actions|OTHER: Relaxation|OTHER: Acceptability questionnaire|OTHER: Observation of Virtual Actions (step 4)|OTHER: Performing Virtual Actions|OTHER: Haptic stimulation|OTHER: Without haptic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Safety, Tolerability, and Efficacy of ST-400 for Treatment of Transfusion-Dependent Beta-thalassemia (TDT)
Status: COMPLETED
Conditions: Transfusion Dependent Beta-thalassemia
Interventions: GENETIC: ST-400 Investigational product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Calcipotriol Plus Betamethasone Gel Versus Calcipotriol Scalp Solution in Scalp Psoriasis
Status: COMPLETED
Conditions: Psoriasis of Scalp
Interventions: DRUG: Calcipotriol plus betamethasone dipropionate (LEO80185 gel)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Using Social Norms to Encourage People to Exercise More
Status: UNKNOWN
Conditions: Physical Activity
Interventions: BEHAVIORAL: Email invitation|BEHAVIORAL: Social norm|BEHAVIORAL: Intrinsic, health motive|BEHAVIORAL: Extrinsic, reward motive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Antiretroviral Treatment Interruption (ATI) Study to Evaluate the Impact of Genetically Modified Autologous Cells (AGT103-T) to Suppress Human Immunodeficiency Virus Replication in the Absence of Antiretroviral Therapy
Status: ENROLLING_BY_INVITATION
Conditions: HIV
Interventions: OTHER: Antiretroviral Therapy Interruption(ATI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hypertonic Saline for Acute Bronchiolitis
Status: COMPLETED
Conditions: Bronchiolitis, Viral|Saline Solution, Hypertonic
Interventions: DRUG: Nebulized 3% saline|DRUG: Nebulized 0.9% Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type
Status: RECRUITING
Conditions: Agitation in Patients With Dementia of the Alzheimer's Type
Interventions: DRUG: AVP-786|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Danazol on Endometrial αvβ3 Integrin Expression in Patients With Unexplained Recurrent Implantation Failure
Status: COMPLETED
Conditions: Unexplained Infertility
Interventions: PROCEDURE: Pre-treatment endometrial biopsy|DRUG: Danazol|PROCEDURE: Post-treatment endometrial biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microbiological Assessment of Bile in Patients Undergone to Endoscopic Retrograde Cholangiography (ERCP): the "Microbile Registry"
Status: RECRUITING
Conditions: Jaundice, Obstructive|Jaundice; Malignant|Choledocholithiasis|Biliary Stricture|Biliary Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Docetaxel, Cisplatin (TP) + Radiation +/- Cetuximab in Larynx Carcinoma (CA)
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Hypopharynx|Larynx Carcinoma
Interventions: RADIATION: Radiation|DRUG: Cetuximab|DRUG: Docetaxel|DRUG: Cisplatin (TP)|DRUG: 5-Fluorouracil (TPF) (only until Feb 2009)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antimicrobial Synthetic Bone Grafts
Status: COMPLETED
Conditions: Bone Infection|Bone Graft Infection
Interventions: DEVICE: antimicrobial synthetic bone graft|DEVICE: parentaral antimicrobials and pure bone grafts
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medium vs Low Oxygen Threshold for the Surfactant Administration
Status: NOT_YET_RECRUITING
Conditions: Respiratory Distress Syndrome
Interventions: DRUG: Poractant Alfa 80 mg/mL Intratracheal Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of the Information Follow-up Given to Patients on Their Disease Understanding and Therapeutic Adherence in Patients Under Direct Oral Anticoagulants and With Atrial Fibrillation in a Cardiology Department
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: OTHER: Specialized nurse consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety of Vonoprazan in Adolescents With Symptomatic Gastroesophageal Reflux Disease
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DRUG: Vonoprazan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hypotension Prediction Index (HPI) in Patients Undergoing Robotic Assisted Radical Prostatectomy
Status: COMPLETED
Conditions: Hypotension During Surgery
Interventions: DEVICE: Hypotension Prediction Index|DEVICE: No Hypotension Prediction Index
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: THE EFFECTS OF EARLY PERIOD KINESIOTAPE
Status: COMPLETED
Conditions: Rotator Cuff Injuries|Rotator Cuff Tears
Interventions: OTHER: Kinesiotape|OTHER: Shamtape|OTHER: Standard Physiotherapy Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TNF Blockade With Remicade in Active Lupus Nephritis WHO Class V (TRIAL )
Status: TERMINATED
Conditions: Lupus Erythematosus, Systemic|Lupus Nephritis
Interventions: DRUG: infliximab|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nirogacestat for Adults With Desmoid Tumor/Aggressive Fibromatosis (DT/AF)
Status: ACTIVE_NOT_RECRUITING
Conditions: Desmoid Tumor|Aggressive Fibromatosis
Interventions: DRUG: Nirogacestat oral tablet|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetic and -Dynamic Study of PR-15, an Inhibitor of Platelet Adhesion
Status: COMPLETED
Conditions: Thrombosis|Acute Coronary Syndrome|Myocardial Infarction|Stroke
Interventions: DRUG: revacept (PR-15)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cetuximab, Bevacizumab & 5FU/Leucovorin vs. Oxaliplatin, Bevacizumab & 5FU/Leucovorin in Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Bevacizumab|DRUG: Oxaliplatin|DRUG: Leucovorin|DRUG: Fluorouracil|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Different Types of Exercises in Women With Fibromyalgia Syndrome.
Status: COMPLETED
Conditions: Fibromyalgia Syndrome
Interventions: OTHER: Supervised Aerobic Plus Stretching Exercises|OTHER: Supervised Resistance Plus Stretching Exercises Group|OTHER: Home-based Stretching Exercises Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lerapolturev (PVSRIPO) in GBM
Status: RECRUITING
Conditions: Recurrent Supratentorial Glioblastoma
Interventions: DRUG: Lerapolturev|DRUG: Lomustine Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Irinotecan and 5-FU as Second-line Therapy for Patients With ESCC
Status: NOT_YET_RECRUITING
Conditions: Esophageal Cancer
Interventions: DRUG: liposomal irinotecan|DRUG: 5-FU|DRUG: LV|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neo-adjuvant Chemo and Immunotherapy in The Pre-operAtive Treatment of Locally Advanced cholangIOcarciNoma
Status: RECRUITING
Conditions: Cholangiocarcinoma
Interventions: DRUG: Durvalumab 1120 mg|DRUG: Durvalumab 1500 mg|DRUG: Tremelimumab i.v. at 300 mg|COMBINATION_PRODUCT: Cisplatin (CDDP) 25 mg/mq i.v|COMBINATION_PRODUCT: Gemcitabine (GEM) 1000 mg/mq i.v.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Solo and Non-solo Approach for Laparoscopic Appendectomy (SOLOAP)
Status: UNKNOWN
Conditions: Appendicitis|Laparoscopic
Interventions: PROCEDURE: nonsolo LA|PROCEDURE: solo LA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dentin Hypersensitivity Following Non-surgical Periodontal Therapy With Hand or Ultrasonic Instruments
Status: COMPLETED
Conditions: Periodontal Disease|Dentin Sensitivity
Interventions: DEVICE: manual and ultrasonic instruments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Retention of Maxillary Complete Dentures Modified With Titanium Dioxide Nanoparticles: A Randomized Crossover Clinical Trial.
Status: COMPLETED
Conditions: Denture Retention|Complete Dentures
Interventions: OTHER: Complete denture base modified by Titanium dioxide nanoparticles.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Trial of Intrathecal Rituximab for Progressive Multiple Sclerosis Patients
Status: COMPLETED
Conditions: Primary Progressive Multiple Sclerosis|Secondary Progressive Multiple Sclerosis
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Relative Bioavailability of Two Abiraterone Acetate Suspension Formulations Compared to the Abiraterone Acetate Tablet Formulation in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Abiraterone acetate suspension Formulation 1|DRUG: Abiraterone acetate suspension Formulation 2|DRUG: Abiraterone acetate tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: The Efficacy of Long-Course Treatment Using Vibrating Capsules for Chronic Constipation
Status: COMPLETED
Conditions: Chronic Functional Constipation
Interventions: DRUG: Treat with Vibrabot capsules for at least 7 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating The Excretion Of Moxidectin Into The Breast Milk Of Lactating, Non-Breastfeeding Women
Status: COMPLETED
Conditions: Infection
Interventions: DRUG: Moxidectin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy of Paroxetine in the Prevention of Depressive Syndrome in Patients With Chronic Hepatitis C Treated by PEG-Interferon Alfa Plus Ribavirin
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Paroxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Manual Super Small Incision Cataract Surgery and Phacoemulsification
Status: COMPLETED
Conditions: Cataract|Phacoemulsification
Interventions: PROCEDURE: MSSICS|PROCEDURE: Phacoemulsification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accuracy of Self-estimation of Blood Alcohol Concentration Compared to Object Values
Status: COMPLETED
Conditions: Alcohol Intoxication
Interventions: BEHAVIORAL: self estimation of breath alcohol content|DEVICE: breath alcohol content as measured by Alco Sensor IV device|OTHER: drink a beer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Study of Clevidipine Butyrate Injection in the Treatment of Hypertensive Emergency and Sub-emergency
Status: UNKNOWN
Conditions: Hypertensive Emergency
Interventions: DRUG: This is a randomized, single-blind, parallel-controlled clinical study with the original research clevidipine butyrate injection as the positive control drug, which is an equivalence test.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: FX-322 in Adults With Severe Sensorineural Hearing Loss
Status: COMPLETED
Conditions: Hearing Loss, Sensorineural|Noise Induced Hearing Loss|Sudden Hearing Loss
Interventions: DRUG: FX-322|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Active Pregnancy. Mental and Emotional Health Care to Pregnant Woman During and After Coronavirus (COVID-19)
Status: RECRUITING
Conditions: Mental Health Wellness|Emotional Problem
Interventions: OTHER: Moderate exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Adoptive T Cell Therapy Following HER2-Pulsed Dendritic Cell Vaccine & Pepinemab /Trastuzumab in Patients w/ Metastatic HER2+ Breast Cancer
Status: RECRUITING
Conditions: HER2-positive Breast Cancer
Interventions: BIOLOGICAL: Dendritic Cell (DC1) Vaccine|DRUG: Trastuzumab|DRUG: Pepinemab|BIOLOGICAL: T-Cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Trial of Serostim® in the Treatment of Subjects With Human Immunodeficiency Virus-associated Adipose Redistribution Syndrome (HARS)
Status: COMPLETED
Conditions: Human Immunodeficiency Virus-associated Adipose Redistribution Syndrome (HARS)|Human Immunodeficiency Virus Infections
Interventions: DRUG: Serostim®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of C-met Kinase Inhibitor HS-10241 in Subjects With Advanced Solid Tumours
Status: UNKNOWN
Conditions: Carcinoma|Solid Tumor, Adult
Interventions: DRUG: HS-10241
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Minimally Invasive Restorative Techniques on Pregnant Women Oral Health Related Quality of Life
Status: COMPLETED
Conditions: Quality of Life|Dental Caries
Interventions: DRUG: Papacarie|PROCEDURE: Atraumatic Restorative Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ketorolac for the Treatment of Inflammation and Pain Associated With Cataract Surgery
Status: COMPLETED
Conditions: Cataract Extraction|Pain|Inflammation
Interventions: DRUG: ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Examine the Safety of Different Doses of BG-68501 Given to Participants With Advanced-Stage Tumors
Status: RECRUITING
Conditions: Breast Cancer|Small Cell Lung Cancer|Ovarian Cancer|Gastric Cancer|Hormone-receptor-positive Breast Cancer|Hormone Receptor Positive HER-2 Negative Breast Cancer|Advanced Solid Tumor|Endometrial Cancer|Prostate Cancer
Interventions: DRUG: BG-68501|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eradication of Helicobacter Pylori With Bismuth Agent Quadruple and Traditional Chinese Medicine
Status: NOT_YET_RECRUITING
Conditions: Helicobacter Pylori Infection|Traditional Chinese Medicine|Eradication
Interventions: DRUG: Ban xia xie xin Decoction and bismuth quadruplicate group|DRUG: Bismuth quadruplicate group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Efficacy of PresbiDrops (CSF-1) in Presbyopic Subjects
Status: COMPLETED
Conditions: Presbyopia
Interventions: DRUG: PresbiDrops (CSF-1)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Evaluate the Effect of Multiple Passes on Port Wine Stain Treatments With the Cutera Excel V™ Laser.
Status: SUSPENDED
Conditions: Port-Wine Stain
Interventions: DEVICE: Cutera excel V™ Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Biphasic Insulin Aspart 30 With Metformin in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Safety, Pharmacokinetics and Pharmacodynamics Study of Recombinant Factor VIIa in Adult Patients With Hemophilia A or B
Status: COMPLETED
Conditions: Hemophilia
Interventions: BIOLOGICAL: rhFVIIa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized, Parallel, Comparison, Double-Blind Efficacy & Safety Study of APROVEL Versus Placebo in Chinese Patients With Hypertensive Type II Diabetic Patients With Microalbuminuria
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Irbesartan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunomodulatory Effects of IVIg on Pregnancy Rate of Patient With Recurrent Implantation Failure
Status: COMPLETED
Conditions: Recurrent Implantation Failure
Interventions: DRUG: IVIg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiac Safety Evaluation of P03277
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: P03277 0.1 mmol/kg|DRUG: Moxifloxacin 400mg|DRUG: NaCl 0.9%|DRUG: P03277 0.3 mmol/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: An Analysis of the Effect of Topical Cromolyn Sodium on Rosacea-associated Erythema
Status: COMPLETED
Conditions: Papulopustular Rosacea
Interventions: DRUG: Cromolyn Sodium|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Impact of a Dietary and Nutritional Intervention on Persistent Post-concussive Symptoms
Status: NOT_YET_RECRUITING
Conditions: Brain Injury Traumatic Mild
Interventions: BEHAVIORAL: Experimental: Dietetic counseling|DIETARY_SUPPLEMENT: Active Comparator: Omega-3, vitamin D3 and creatine monohydrate|BEHAVIORAL: Other : Physiotherapy treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pentoxifylline, Atorvastatin, and Vitamin E in Treating Patients With Erectile Dysfunction After Radiation Therapy for Prostate Cancer
Status: COMPLETED
Conditions: Male Erectile Disorder|Prostate Adenocarcinoma|Erectile Dysfunction, CTCAE|Impotence
Interventions: DRUG: Atorvastatin|DRUG: Pentoxifylline|DIETARY_SUPPLEMENT: Vitamin E Compound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SHR-4597 Inhalation in Healthy Subjects and Asthmatic Patients
Status: NOT_YET_RECRUITING
Conditions: Healthy Subjects|Asthmatic Patients
Interventions: DRUG: SHR-4597|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a New Anti-cancer Vaccine for Patients With Non-small Cell Lung Cancer, After Tumor Removal by Surgery
Status: TERMINATED
Conditions: Lung Cancer, Non-Small Cell
Interventions: BIOLOGICAL: Immunotherapeutic GSK2302032A, different formulations
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Chronic Pain Treatment Prior to Gender-affirming Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Transgenderism|Pain Catastrophizing|Pain, Chronic|Gender Identity
Interventions: BEHAVIORAL: Empowered Relief|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Air Pollution and Inhaled Corticosteroids in COPD
Status: NOT_YET_RECRUITING
Conditions: COPD
Interventions: DRUG: LABA+LAMA|DRUG: LABA+LAMA+ICS|OTHER: Filtered Air|OTHER: Diesel Exhaust
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Developing and Testing Delicious and Nutritious for the Old People
Status: COMPLETED
Conditions: Quality of Life|Nutritional Deficiency|Physical Performance
Interventions: OTHER: Sensory optimized meals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Pharmacokinetics and Safety of Risdiplam in Infants With Spinal Muscular Atrophy
Status: RECRUITING
Conditions: Muscular Atrophy, Spinal
Interventions: DRUG: Risdiplam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sublingual Misoprostol in Decreasing Blood Loss Prior to Myomectomy
Status: COMPLETED
Conditions: Blood Loss in Myomectomy
Interventions: DRUG: Misoprostol 400 sublingual|DRUG: placebo 400 sublingual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Quantification of Debris Captured Using TCEP During VIV TAVR With BVF
Status: RECRUITING
Conditions: Aortic Valve Disease
Interventions: DEVICE: VIV TAVR with BVF using TCEP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Steroid Withdrawal and Donor-specific Anti-HLA Antibodies in Renal Transplant Patients
Status: COMPLETED
Conditions: Other Complication of Kidney Transplant|Renal Transplant Rejection
Interventions: DRUG: Prednisone withdrawal|DRUG: Prednisone continuation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Pegfilgrastim With Filgrastim as an Adjunct to Chemotherapy for Acute Myeloid Leukaemia (AML)
Status: COMPLETED
Conditions: Myeloid Leukemia
Interventions: DRUG: filgrastim|DRUG: pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metformin Improves Clinical Pregnancy Rate in Polycystic Ovarian Syndrome Patients
Status: COMPLETED
Conditions: Reproductive Endocrinology|Polycystic Ovarian Syndrome
Interventions: DRUG: CC|DRUG: Placebo tablets|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Indego Exoskeleton for Persons With Hemiplegia Due to CVA
Status: COMPLETED
Conditions: Cerebrovascular Accident (CVA)|Stroke|Hemiplegia
Interventions: DEVICE: Indego Exoskeleton
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of a Remote Training Strategy
Status: ENROLLING_BY_INVITATION
Conditions: Behavior Disorders
Interventions: BEHAVIORAL: Coping Power Program (CPP)|BEHAVIORAL: CBT for Anxiety Treatment in Schools (CATS)|BEHAVIORAL: Check-in/Check-out (CI/CO)|BEHAVIORAL: Initial Training (CC)|BEHAVIORAL: Initial Training plus Video (RV)|BEHAVIORAL: Initial Training plus Video plus Coaching (RV+)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy of Magnesium Sulfate as an Adjuvant in Erector Spinae Plane Block as an Anesthetic Post Operative After Modified Radical Mastectomy
Status: NOT_YET_RECRUITING
Conditions: ESPB, Mg Sulfate,Post Mastectomy
Interventions: DRUG: Magnesium sulfate in erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sustained Virological Suppression and Improvement of Adverse Events of Switching to Raltegravir Study
Status: COMPLETED
Conditions: HIV Infection|Adverse Drug Reaction|Quality of Life
Interventions: DRUG: Raltegravir switch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise as a Primer for Brain Stimulation in Vascular Cognitive Impairment No Dementia (VCIND)
Status: RECRUITING
Conditions: Vascular Cognitive Impairment|Mild Cognitive Impairment
Interventions: OTHER: tDCS|OTHER: Exercise|OTHER: Sham stimulation|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Predicting Adenomatous Polyps in the Colon Using Images of a Human Tongue
Status: RECRUITING
Conditions: Colorectal Neoplasms|Gastrointestinal Microbiome
Interventions: DEVICE: Gixam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: EaseVRx for the Reduction of Chronic Pain and Opioid Use
Status: COMPLETED
Conditions: Chronic Low-back Pain
Interventions: DEVICE: EaseVRx headset|DEVICE: Active control VR sham program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of Amplitude-Modulated Electromagnetic Fields in the Treatment of Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Advanced Hepatocellular Carcinoma
Interventions: DEVICE: TheraBionic device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers
Status: COMPLETED
Conditions: Tobacco Use Disorder
Interventions: OTHER: Very low nicotine content cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Adapalene-BPO Gel Associated With Doxycycline Hyclate 100 mg in the Treatment of Severe Acne Vulgaris
Status: COMPLETED
Conditions: Severe Acne Vulgaris
Interventions: DRUG: Adapalene BPO Gel associated with Doxycyline Hyclate|DRUG: Vehicle Gel associated with Doxycycline Hyclate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sodium Thiosulfate to Preserve Cardiac Function in STEMI
Status: UNKNOWN
Conditions: Myocardial Infarction|Heart Failure
Interventions: DRUG: Sodium thiosulfate|DRUG: Sodium chloride 0.9%|PROCEDURE: primary percutaneous coronary intervention|OTHER: cardiac magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of WA-NG Telescope Prosthesis in Patients With End-stage Age-related Macular Degeneration
Status: WITHDRAWN
Conditions: Age Related Macular Degeneration
Interventions: DEVICE: Telescope prosthesis|DEVICE: WA-NG Telescope Prothesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Treatment With a Sodium-glucose Co-transporter 2 Inhibitor in High-risk Patients With Acute Heart Failure
Status: RECRUITING
Conditions: Acute Heart Failure
Interventions: DRUG: Empagliflozin 10 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Seizure Therapy for Bipolar Mania
Status: COMPLETED
Conditions: Bipolar Disorder, Manic
Interventions: DEVICE: Magpro X100 + Option|DEVICE: ThymatronSystem Ⅳ Electroconvulsive System|OTHER: treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Adaptation, Usability, and Feasibility of a Mobile Health (mHealth) System to Improve Type 2 Diabetes Self-management in Thailand
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: Mobile health system|OTHER: E-mail reports and technical support for mHealth system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: One-stage Maxillary Sinus Elevation Using a Bone Core Containing an Implant From the Mandibular Symphysis
Status: UNKNOWN
Conditions: Atrophied Posterior Maxilla
Interventions: PROCEDURE: Open sinus lift using chin bone graft|PROCEDURE: Sinus lift using bone ring containing the implant.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plan Block for Postoperative Analgesia
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Erector Spinae Plan Block|PROCEDURE: Oblique subcostal TAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The PROtein Enriched MEDiterranean Diet and EXercise Trial for Older Adults at Risk of Undernutrition
Status: ACTIVE_NOT_RECRUITING
Conditions: Cognitive Impairment|Poor Nutrition|Cognitive Decline
Interventions: BEHAVIORAL: A Protein Enriched Mediterranean Diet (PROMED) Intervention|BEHAVIORAL: A Protein Enriched Mediterranean Diet & Exercise (PROMED-EX) Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of a New Interactive Device on the Motor and Functional Abilities of Children With Bilateral Cerebral Palsy
Status: UNKNOWN
Conditions: Cerebral Palsy
Interventions: BEHAVIORAL: HABIT-ILE with REAtouch®|BEHAVIORAL: HABIT-ILE without REAtouch®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Dato-DXd|DRUG: Durvalumab|DRUG: Paclitaxel|DRUG: Nab-paclitaxel|DRUG: Gemcitabine|DRUG: Carboplatin|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allergy Diagnostic Test Based on Microchip Technology
Status: NOT_YET_RECRUITING
Conditions: Allergy|Allergy;Food|Allergy Pollen|Allergy Drug
Interventions: DIAGNOSTIC_TEST: Routine allergy tests|DIAGNOSTIC_TEST: Newly developed microarray-based diagnostic test system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of AK119 (Anti-CD73 Antibody), a Treatment for COVID-19, in Healthy Subjects
Status: COMPLETED
Conditions: Coronavirus Disease 2019 (COVID-19)
Interventions: DRUG: AK119|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Apixaban in Reducing Restenosis and Limb Loss in PAD Patients.
Status: UNKNOWN
Conditions: Critical Limb Ischemia
Interventions: DRUG: Apixaban|DRUG: ASA|DRUG: Clopidogrel 75mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Active or Placebo Attentional Bias Modification Treatment (ABMT) to Either Cognitive Behavioral Group Therapy (CBGT) or Psychoeducational Control Intervention (PCI) for Anxiety Disorders in Children
Status: UNKNOWN
Conditions: Generalized Anxiety Disorder|Separation Anxiety Disorder|Social Anxiety Disorder
Interventions: OTHER: Attentional Bias Modification Treatment (ABMT) - Active|OTHER: Attentional Bias Modification Treatment - Placebo|BEHAVIORAL: Cognitive Behavioral Group Therapy|BEHAVIORAL: Psychoeducational Control Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: DEVICE: Stannous Fluoride dentifice|OTHER: Sodium Monofluorophosphate dentifrice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reboxetine and Citalopram as an Adjunct Treatment to Second Generation Antipsychotics in the Treatment of Negative Symptoms of Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DRUG: Reboxetine|DRUG: citalopram (SSRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Abobotulinum Toxin Versus Neubotulinum Toxin Injection For Hemifacial Spasm in Thai Patients
Status: NOT_YET_RECRUITING
Conditions: Hemifacial Spasm
Interventions: DRUG: Injection botulinum toxin A ( Dysport 100 unit or Neuronox 33.33 unit)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Effects of ODM-108: in Healthy Male Volunteers
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: ODM-108 Part I|DRUG: Placebo Part I|DRUG: ODM-108-Part II|DRUG: Placebo Part II|DRUG: ODM-108 Part III|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Performance of Toric Silicone Hydrogel Contact Lenses Following One Month of Daily Wear
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: Fanfilcon A toric lens|DEVICE: Lotrafilcon B toric lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Perifosine + Lenalidomide and Dexamethasone for Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Perifosine|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Periviable Birth Plan
Status: UNKNOWN
Conditions: Pregnancy, High Risk|Parturition Complication as Antepartum Condition|Anxiety|PTSD|PreTerm Birth
Interventions: BEHAVIORAL: Periviable Birth Plan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Prophylactic Antibiotics on Bloodstream Infections After Liberation From Extracorporeal Membrane Oxygenation
Status: NOT_YET_RECRUITING
Conditions: Catheter-Related Infections
Interventions: DRUG: Vancomycine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combined Spinal-epidural Anesthesia for Cesarean Section Without Prophylactical Prehydration and Vasopressors
Status: UNKNOWN
Conditions: Cesarean Section|Anesthesia, Spinal
Interventions: DRUG: bupivacaine|DRUG: ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Adoptive Cellular Therapy and Radiation Therapy After Surgery in Treating Patients With Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: RADIATION: Only radiation therapy|OTHER: Radiation therapy plus DC-CIK cellular therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Injectable Pharmacotherapy for Opioid Use Disorders (IPOD)
Status: COMPLETED
Conditions: Opioid Use Disorders
Interventions: DRUG: XR-NTX|BEHAVIORAL: XR-NTX+PN|BEHAVIORAL: ETAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Elotuzumab in Combination With Lenalidomide and Dexamethasone in Subjects With Multiple Myeloma and Various Levels of Renal Function
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Lenalidomide|DRUG: Dexamethasone|DRUG: Dexamethasone|DRUG: Dexamethasone|BIOLOGICAL: Elotuzumab (BMS-901608; HuLuc63)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Unravelling Mechanisms of Fructose vs Glucose Consumption in the Pathogenesis and Progression of NAFLD
Status: UNKNOWN
Conditions: Non-alcoholic Fatty Liver Disease|Non-alcoholic Steatohepatitis
Interventions: DIETARY_SUPPLEMENT: Fructose|DIETARY_SUPPLEMENT: Glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetic Study of DYANAVEL XR (Amphetamine) Extended-release Oral Suspension, in Children Aged 4 to 5 Years
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Amphetamine Extended Release Suspension [Dyanavel]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigate, Following Cataract Surgery With IOL in Conjunction With Intracanalicular Dexamethasone Insert
Status: COMPLETED
Conditions: Glaucoma, Primary Open Angle|Cataract
Interventions: DRUG: Intracanalicular Dexamethasone, 0.4 mg insert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of the RemedRugby Program
Status: COMPLETED
Conditions: Schizophrenia|Social Cognition|Self Esteem|Empowerment|Recovery
Interventions: OTHER: REMEDRUGBY PROGRAM|OTHER: TOUCH RUGBY PROGRAM|OTHER: TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone and Azeliragon for Management of Post-Resection Cerebral Edema in Patients With Glioblastoma
Status: NOT_YET_RECRUITING
Conditions: Glioblastoma|Malignant Glioma
Interventions: DRUG: Azeliragon|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Dexamethasone|PROCEDURE: Magnetic Resonance Imaging of the Brain with and without Contrast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SIGHT Study: Cost-effectiveness of InnFocus Microshunt Implantation vs. Trabeculectomy.
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Open-angle Glaucoma
Interventions: PROCEDURE: PRESERFLO Microshunt implantation|PROCEDURE: Trabeculectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dosage Determination Trial for Indigo Naturalis Extract in Oil Ointment
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: Indirubin 200μg/g|DRUG: Indirubin 100 μg/g|DRUG: Indirubin 50 μg/g|DRUG: Indirubin 10 μg/g
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: FCT Study: Reducing the Need for Out-of-Home Placements
Status: ACTIVE_NOT_RECRUITING
Conditions: Behavior Problem|Mental Disorder|Emotional Problem
Interventions: BEHAVIORAL: Family Centered Treatment|BEHAVIORAL: Level II or Level III Out of Home Placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Total Marrow and Lymphoid Irradiation and Chemotherapy Before Donor Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Adult Acute Lymphoblastic Leukemia in Complete Remission|Acute Myeloid Leukemia in Remission|Previously Treated Myelodysplastic Syndrome|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Childhood Acute Lymphoblastic Leukemia in Complete Remission
Interventions: PROCEDURE: Bone Marrow Transplantation|DRUG: Cyclophosphamide|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|DRUG: Mycophenolate Mofetil|PROCEDURE: Peripheral Blood Stem Cell Transplantation|DRUG: Tacrolimus|RADIATION: Total Marrow Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxytocin Pathways and the Health Effects of Human-Animal Interaction
Status: COMPLETED
Conditions: HAI
Interventions: BEHAVIORAL: Pet dog|BEHAVIORAL: Unfamiliar dog|BEHAVIORAL: Nonsocial control
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Learn About the Effects of Medicines That Help in Thinning the Blood in People With Atrial Fibrillation (AF) Between 2016 and 2020 in France
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: No OAC|DRUG: VKA|DRUG: apixaban|DRUG: rivaroxaban|DRUG: dabigatran
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p