pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Prospective Observational Cohort Study Evaluating Resection Rate in Patients With Metastatic Colorectal Cancer Treated With Aflibercept in Combination With FOLFIRI - Observatoire résection
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer|Colorectal Neoplasms
Interventions: DRUG: Fluorouracil|DRUG: Aflibercept|DRUG: Irinotecan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clareon PanOptix Pro vs. Clareon PanOptix - Study A
Status: RECRUITING
Conditions: Aphakia|Presbyopia
Interventions: DEVICE: CPO Pro IOL|DEVICE: CPO IOL|PROCEDURE: Cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pooled Analysis of Clinical Data From Six GSK Studies to Investigate the Efficacy of a Dentifrice Containing 67% Weight by Weight (w/w) Sodium Bicarbonate on Gingivitis and Plaque Accumulation
Status: COMPLETED
Conditions: Gingivitis|Dental Plaque
Interventions: OTHER: Sodium bicarbonate|OTHER: Control Dentifrice
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Observational Study for the Assessment of Compliance and Persistence to Rebif® Therapy of Patients With Relapsing-remitting Multiple Sclerosis (MS) and Evaluation of Potential Factors Influencing These Parameters
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Re-evaluation of the Effect Site Model of the PKPD Propofol Eleveld Model
Status: RECRUITING
Conditions: Healthy|Surgery
Interventions: DRUG: fixed propofol infusion 15 mg/kg/h until 1% BSR (burst suppression ratio)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Modified Stereotactic Aspiration and Thrombolysis of Intracerebral Hemorrhage:a Multi-center Controlled Study
Status: UNKNOWN
Conditions: Hypertensive Intracerebral Hemorrhage
Interventions: DEVICE: Stereotactic Aspiration and Thrombolysis|DRUG: conservative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of the Globe® Pulsed Field System for Treating Patients With Symptomatic Paroxysmal or Persistent Atrial Fibrillation
Status: RECRUITING
Conditions: Paroxysmal Atrial Fibrillation|Persistent Atrial Fibrillation
Interventions: DEVICE: Globe Pulsed Field System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Profiling and Targeted Therapy for Advanced Non-Small Cell Lung Cancer, Small Cell Lung Cancer, and Thymic Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung|Carcinoma, Small Cell Lung|Carcinoma, Thymic
Interventions: DRUG: AZD6244|DRUG: MK-2206|DRUG: Lapatinib|DRUG: Erlotinib|DRUG: Sunitinib|PROCEDURE: Molecular Profiling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Resistant Starch on Bowel Habits, Fecal Short Chain Fatty Acids and Gut Microbiota in Parkinson Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DIETARY_SUPPLEMENT: Resistant starch|OTHER: Recommendation with regard to nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Brain Structure and Neurocognitive Development in Sickle Cell Disease; a Longitudinal Cohort Study (BRICK Study)
Status: RECRUITING
Conditions: Brain Development Abnormality|Sickle Cell Disease
Interventions: DIAGNOSTIC_TEST: MR scan of the brain|DIAGNOSTIC_TEST: Blood work|DIAGNOSTIC_TEST: Neurological examination|DIAGNOSTIC_TEST: Neuropsychological assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of SPD465 in Young Adult Drivers With Attention-Deficit Hyperactivity Disorder (ADHD) Using Driving Simulators
Status: WITHDRAWN
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: SPD465|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Tranexamic Acid Versus Uterine Cooling at Caesarean Section
Status: COMPLETED
Conditions: Hemorrhage of Cesarean Section and/or Perineal Wound|Postpartum Hemorrhage|Uterine Atony
Interventions: DRUG: Tranexamic Acid|PROCEDURE: Intraoperative Uterine Cooling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of Chlorhexidine Gluconate Gel Dressing in Preventing Surgical Drain Site Infection
Status: WITHDRAWN
Conditions: Drain Site Complication
Interventions: DEVICE: 3M™ Tegaderm™ CHG Chlorhexidine Gluconate I.V. Securement Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Antipsychotics in Children 2: Studying TDM in an RCT
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: OTHER: Therapeutic Drug Monitoring|OTHER: Risperidone plasma level
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: To Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD8233 After Multiple Dose Administration in Subjects With Dyslipidemia
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: AZD8233 subcutaneous injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation for Chronic Subjective Tinnitus
Status: COMPLETED
Conditions: Tinnitus, Subjective
Interventions: PROCEDURE: Repetitive Transcranial Magnetic Stimulation|PROCEDURE: Sham stimulation|DRUG: Ginkgo Biloba Extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing Tolerance in Cow Milk Protein Allergy Patients: Milk Ladder or Direct Milk Administration?
Status: NOT_YET_RECRUITING
Conditions: Cow Milk Allergy|Tolerance
Interventions: DIETARY_SUPPLEMENT: Direct Milk antigen reintroduction|DIETARY_SUPPLEMENT: Milk ladder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: S-1 Versus 5-FU Bolus in Metastatic Pancreatic Cancer Patients Previously Treated With Gemcitabine-Based Regimen
Status: TERMINATED
Conditions: Pancreatic Neoplasm|Neoplasm Metastasis
Interventions: DRUG: S-1|DRUG: 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine, Carboplatin, Paclitaxel, and Bevacizumab in Recurrent Advanced Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: carboplatin|DRUG: hydroxychloroquine|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Entecavir Intensification for Persistent HBV Viremia in HIV-HBV Infection
Status: COMPLETED
Conditions: HIV Infections|Hepatitis B
Interventions: DRUG: Entecavir with continued standard of care antiretroviral therapy|DRUG: continued standard of care with tenofovir in addition to emtricitabine or lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EXtended Therapy in Hepatitis C Genotype 3 Infected Patients
Status: TERMINATED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Peginterferon alfa-2b (Pegetron) plus ribavirin (Rebetol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dapagliflozin Tablet 10 mg Relative to Forxiga® Tablets 10 mg
Status: NOT_YET_RECRUITING
Conditions: Healthy Subjects
Interventions: DRUG: Dapagliflozin-Test product|DRUG: Dapagliflozin-Reference product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: GRAvity- Versus Wall Suction-drIven Large Volume Thoracentesis: a rAndomized Controlled Study (GRAWITAS Study)
Status: RECRUITING
Conditions: Thoracentesis|Pleural Effusions, Chronic|Pulmonary Edema
Interventions: OTHER: Standard Suction Thoracentesis|OTHER: Gravity Thoracentesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Artificial Intelligence to Implement Cost-saving Strategies for Colonoscopy Screening Based on in Vivo Prediction of Polyp Histology
Status: RECRUITING
Conditions: Colonic Neoplasms
Interventions: DEVICE: Standard, high-definition colonoscopy with the use of CADe assistance|DEVICE: Standard, high-definition colonoscopy with the use of CADe/CADx assistance, no leave-in-situ|DEVICE: Standard, high-definition colonoscopy with the use of CADe/CADx assistance, leave-in-situ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Balanced Crystalloid Solutions for Acute Pancreatitis
Status: UNKNOWN
Conditions: Acute Pancreatitis
Interventions: DRUG: Balanced crystalloid solution|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inhaled Gaseous Nitric Oxide (gNO) Antimicrobial Treatment of Difficult Bacterial and Viral Lung (COVID-19) Infections
Status: TERMINATED
Conditions: Respiratory Tract Infections|Corona Virus Infection
Interventions: DRUG: Nitric Oxide 0.5 % / Nitrogen 99.5 % Gas for Inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dental Extractions in Patients Under Dual Antiplatelet Therapy
Status: COMPLETED
Conditions: Blood Coagulation Disorders
Interventions: DEVICE: HemCon Dental Dressing|DEVICE: Oxidized Cellulose Gauze
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Angiogenesis and Fibrosis in Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction|Fibrosis|Neovascularization, Pathologic
Interventions: PROCEDURE: Cardiac MRI scan|RADIATION: CT-PET scan|RADIATION: CT-coronary angiogram
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Efficacy and Safety Study of SRM003 in the Treatment of Subjects Undergoing Creation of an Arteriovenous Fistula to Facilitate Hemodialysis Access
Status: COMPLETED
Conditions: Arteriovenous Fistula
Interventions: BIOLOGICAL: SRM003|OTHER: Participating Site's standard practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Temozolomide in Subjects With Brain Metastases of Either Malignant Melanoma, Breast, or Non-small Cell Lung Cancer (P02064)
Status: COMPLETED
Conditions: Metastases of Central Nervous System|Melanoma|Breast Neoplasm|Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Efficacy and Safety of Nanogen's Darbepoetin Alfa With Aranesp® (Amgen) in the Treatment of Anemia in Chronic Kidney Disease Patients on Dialysis (CKD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Anemia|Chronic Kidney Disease Requiring Chronic Dialysis
Interventions: BIOLOGICAL: Stimus (NNG-DEPO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Threshold Inspiratory Trainer Versus Trigger Sensitivity Adjustment on Weaning From Mechanical Ventilation
Status: COMPLETED
Conditions: Respiratory Failure
Interventions: OTHER: Threshold inspiratory muscle trainer device|OTHER: Adjusting mechanical ventilator trigger sensitivity|OTHER: Chest physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Imaging Study to Investigate Safety and Diagnostic Performance of rhPSMA 7.3 (18F) PET Ligand in Suspected Prostate Cancer Recurrence (SPOTLIGHT)
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: rhPSMA-7.3 (18F) Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Linagliptin on Left Ventricular Myocardial DYsfunction in Patients With Type 2 DiAbetes Mellitus and Concentric Left Ventricular Geometry
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Left Ventricular Systolic Dysfunction
Interventions: DRUG: Linagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fatigue and Interleukin-1 (IL-1) Blockade in Primary Sjøgrens Syndrome
Status: COMPLETED
Conditions: Fatigue|Primary Sjogren
Interventions: DRUG: Anakinra|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hemodialysis Reliable Outflow (HeRO) Vascular Access Patency Study
Status: COMPLETED
Conditions: Renal Failure Chronic Requiring Hemodialysis
Interventions: DEVICE: HeRO Vascular Access Device|DEVICE: Conventional ePTFE hemodialysis graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Albendazole Dose Finding and Pharmacokinetics in Children and Adults
Status: COMPLETED
Conditions: Trichuriasis|Hookworm Infections
Interventions: DRUG: Albendazole|DRUG: Albendazole|DRUG: Albendazole|DRUG: Albendazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TreatMent of ActInic KerAtosis Lesions : pharmacoepiDemiological Study of the Impact in Real Life of ingenOl Mebutate Gel (Picato®) on Patients Satisfaction
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Ingenol mebutate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Effects of Eccentric Training on a Cycle Ergometer, Versus Conventional Concentric Training
Status: COMPLETED
Conditions: Readaptation to Effort|Coronaropathy|Chronic Obstructive Pulmonary Disease
Interventions: OTHER: conventional rehabilitation program (including concentric cycle ergometer)|OTHER: cycling included into a conventional rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Safety and Pharmacokinetic/Pharmacodynamic Study of CKD-841 in Postmenopausal Female, Phase 1
Status: UNKNOWN
Conditions: Early Puberty
Interventions: DRUG: CKD-841 A-1 3.75mg|DRUG: CKD-841 A-1 1.88mg|DRUG: CKD-841 D 2.92mg|DRUG: Leuplin Inj. 3.75 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prevention Post Operative Nausea Vomiting in Ambulatory Gynecologic Laparoscopy
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Dexamethasone|DRUG: Ondansetron|DRUG: Dimenhydrinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Genetic Risk and Health Coaching for Type 2 Diabetes and Coronary Heart Disease
Status: COMPLETED
Conditions: Coronary Heart Disease, Susceptibility to, 5|Prediabetic State
Interventions: BEHAVIORAL: Health coaching|GENETIC: Genetic risk counseling|BEHAVIORAL: Standard risk assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Scoliosis-Specific Exercises for At-Risk AIS Curves
Status: ACTIVE_NOT_RECRUITING
Conditions: Adolescent Idiopathic Scoliosis
Interventions: BEHAVIORAL: Scoliosis Specific Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Protein and Fiber at Breakfast on Appetite, Blood Sugar, and Cholesterol
Status: COMPLETED
Conditions: Brain Activity|Appetite|Ingestive Behavior|Glucose Control|Cholesterol
Interventions: OTHER: Dietary control of protein and fiber intake at breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: 129 Xenon Imaging in Patients Treated With Sotatercept
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Hypertension|Pulmonary Arterial Hypertension
Interventions: DRUG: 129Xe Hyperpolarized
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Randomized Controlled Trial to Evaluate Personalized Prediction and Adaptation Tools in Psychotherapy
Status: COMPLETED
Conditions: Feedback, Psychological
Interventions: BEHAVIORAL: Cognitive Behavior Therapy|BEHAVIORAL: CBT plus Feedback|BEHAVIORAL: CBT plus Feedback plus CST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Manual Therapy Versus Stretching Exercise Versus Routine Physical Therapy on Work-related Pain, Among Chefs
Status: COMPLETED
Conditions: Neck Pain
Interventions: OTHER: Routine Physical Therapy|OTHER: Manual Therapy And Routine Physical Therapy|OTHER: Stretching Exercises And Routine Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Docetaxel Plus Carboplatin in Chemonaive Hormone-Refractory Prostate Cancer (HRPC) Patients
Status: COMPLETED
Conditions: Hormone-Refractory Prostate Cancer
Interventions: DRUG: Docetaxel, Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OphtAI Diagnostic Performance Validation for Automated Screening of Eye Diseases
Status: RECRUITING
Conditions: Diabetic Retinopathy|Diabetic Macular Edema|Age-Related Macular Degeneration|Age-related Maculopathy|Glaucoma
Interventions: DEVICE: Eye Fundus Double Capture for Eye Diseases Screening with OphtAI Medical Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Ghrelin, Growth Hormone and Cortisol Interaction in Growth Hormone Deficient Patients
Status: COMPLETED
Conditions: Hypopituitarism
Interventions: DRUG: Human acylated ghrelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Translational Research Center for TBI and Stress Disorders: Virtual Assessment of Deployment Trauma and Rehabilitation
Status: RECRUITING
Conditions: TBI (Traumatic Brain Injury)|PTSD
Interventions: BEHAVIORAL: V-TRACTS Assessment/Feedback|BEHAVIORAL: OPTIONAL Brief Assessment of Thinking|BEHAVIORAL: OPTIONAL STEP-Home-Brief|BEHAVIORAL: OPTIONAL At-home Exercise Program|BEHAVIORAL: OPTIONAL Referral to 12-week STEP-Home|BEHAVIORAL: OPTIONAL Clinical Referral
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of QL1706 in Combination With Chemotherapy in PD-L1-Negative Non-small Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer
Interventions: DRUG: QL1706|DRUG: Tilesizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability and PPI Effects of CC-92480 Test and Reference Formulations in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Rabeprazole|DRUG: CC-92480
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Weight Maintenance With Dipeptidyl Peptidase 4 (DPP4) Inhibitor Sitagliptin in Combination With Metformin After Liragludite Induced Weight Loss
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Body Weight
Interventions: DRUG: sitagliptin and metformin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cryoablation Combined With Tislelizumab Plus Lenvatinib as Second-line or Later Therapy in Advanced Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Advanced Hepatocellular Carcinoma
Interventions: DRUG: Tislelizumab|DRUG: lenvatinib|COMBINATION_PRODUCT: US/CT-guided Percutaneous Cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Iron Isomaltoside Versus Oral Iron Supplementation for Treatment of Iron Deficiency in Pregnancy.
Status: COMPLETED
Conditions: Iron Deficiency Anemia of Pregnancy
Interventions: DRUG: Iron Isomaltoside 1000|DRUG: ferrous fumarate with ascorbic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decitabine Followed by Idarubicin and Cytarabine in Treating Patients With Relapsed or Refractory AML and MDS
Status: TERMINATED
Conditions: Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Myeloid Leukemia|Refractory Anemia With Excess Blasts
Interventions: DRUG: decitabine|DRUG: idarubicin|DRUG: cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Tian Jiu Therapy for Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis (AR)
Interventions: DRUG: herbal patches of Tian Jiu group|DRUG: placebo patches of placebo-control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: 3 Tesla MRI in Patients With Bladder Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Bladder Cancer
Interventions: PROCEDURE: Specimen Ultra-High field MRI|DRUG: chemotherapy|PROCEDURE: Cystectomy and Lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Postoperative ICC Analgesia
Status: COMPLETED
Conditions: Postoperative Analgesia
Interventions: DRUG: Ropivacain|DRUG: NaCl 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Finding Study in Physically Frail Elderly to Measure 25(OH) Vitamin D Levels After Supplementation With Hy.D Calcifediol 25 SD/S and Vitamin D3
Status: COMPLETED
Conditions: Pre-frail Elderly|Frail Elderly
Interventions: DIETARY_SUPPLEMENT: 5 µg/day Hy.D Calcifediol|DIETARY_SUPPLEMENT: 10 µg/day Hy.D Calcifediol|DIETARY_SUPPLEMENT: 15 µg/day Hy.D Calcifediol|DIETARY_SUPPLEMENT: 20 µg/day vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Surufatinib Plus Cadonilimab in Patients With Unresectable or Metastatic Bile Duct Adenocarcinoma
Status: RECRUITING
Conditions: Bile Duct Adenocarcinoma
Interventions: DRUG: surufatinib plus cadonilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Diabetes Virus Detection and Intervention Trial
Status: COMPLETED
Conditions: Type1 Diabetes Mellitus|Enterovirus
Interventions: DRUG: Ribavirin + Pleconaril|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Low Dose of Colchicine on Platelet Reactivity
Status: RECRUITING
Conditions: Platelet Aggregation, Spontaneous|Coronary Artery Disease
Interventions: DRUG: Colchicine 0.5 MG|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bortezomib in Combination With Gemcitabine and Cisplatin in Advanced or Metastatic Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer|Metastatic
Interventions: DRUG: Bortezomib|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zinc as Enhancer in Immune Recovery After Stem Cell Transplantation for Hematological Malignancies
Status: COMPLETED
Conditions: Stem Cell Transplant Complications
Interventions: DRUG: Zinc Sulfate Oral Product|DRUG: Levofloxacin 500Mg Oral Tablet|DRUG: Fluconazole 200mg tab|DRUG: Acyclovir 400 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Endovascular Brachytherapy Combined With Stent Placement and TACE for HCC With Main Portal Vein Tumor Thrombus
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma|Portal Vein Tumor Thrombus
Interventions: PROCEDURE: Stent and Iodine-125 seed strand implantation|DEVICE: Stent|DEVICE: Iodine-125 seed|DRUG: Epirubicin|DRUG: Ultra-fluid lipiodol|OTHER: Gelatin sponge articles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Daily Pravastatin, Fenofibrate or Pravafen in the Treatment of Combined Hyperlipidemia
Status: COMPLETED
Conditions: Combined Hyperlipidemia
Interventions: DRUG: Pravafen|DRUG: Pravastatin|DRUG: Fenofibrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: One-year Follow-up of Iron in Basal Ganglia - R2*: a Biomarker of Parkinson's Disease Progression?
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: PROCEDURE: Magnetic Resonance Imaging (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Travoprost Intraocular Implant + iStent Infinite vs. iStent Infinite Alone
Status: RECRUITING
Conditions: Glaucoma, Open-Angle
Interventions: DRUG: Travoprost Intraocular Implant|OTHER: Sham procedure|DEVICE: iStent infinite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Psychological Intervention for Child Mental Health Based on Parental Reflective Functioning to Enhance Positive Parenting
Status: RECRUITING
Conditions: Externalizing Problems|Internalizing Problems
Interventions: BEHAVIORAL: Skills4Parenting+|OTHER: Waiting-list (nocebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Myofascial Induction Therapy on Pressure Pain and Ankle Range of Motion.
Status: COMPLETED
Conditions: Fascia|Trigger Point Pain, Myofascial|Range of Motion|Pain
Interventions: PROCEDURE: Calf myofascial technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Adsorbent Recirculating System (MARS®) in Hypoxic Hepatitis
Status: UNKNOWN
Conditions: Hypoxic Hepatitis|Ischemic Hepatitis|Shock Liver|Hypoxic Liver Injury|Acute Liver Failure
Interventions: DEVICE: MARS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Microbiology of C16G2 in Adolescent and Adult Dental Subjects
Status: COMPLETED
Conditions: Dental Caries
Interventions: DRUG: C16G2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II Clinical Study of Pegylated Liposomal Doxorubicin Hydrochloride Injection as 2nd-line or Later Therapy in Patients With Mullerian Carcinoma (Epithelial Ovarian Carcinoma, Primary Carcinoma of Fallopian Tube, Peritoneal Carcinoma) Having Prior Platinum-Based Chemotherapy
Status: COMPLETED
Conditions: Ovarian Neoplasms
Interventions: DRUG: doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Radiation (RT) Concurrent With Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (SCC)
Status: TERMINATED
Conditions: Head and Neck Cancer
Interventions: DRUG: Cetuximab|RADIATION: 50-60 Gy and 70 Gy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Safety,Tolerability,Efficacy of PM01183 and Atezolizumab in Patients w/ Advanced Small Cell Lung Cancer.
Status: RECRUITING
Conditions: Carcinoma, Small Cell Lung
Interventions: DRUG: PM 01183|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transdisciplinary Oral/Oropharyngeal Cancer Research & Care in Head and Neck Cancer (TORCH)
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer
Interventions: OTHER: Blood collection|OTHER: Saliva collection|OTHER: Tissue collection|OTHER: Surveys
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: ParisK: Correlation of Imaging Techniques With Histology
Status: COMPLETED
Conditions: Stroke|Plaque, Atherosclerotic
Interventions: OTHER: Magnetic Resonance Imaging (MRI)|RADIATION: Dual-Energy Computed Tomography (DECT)|OTHER: Ultrasound|OTHER: Transcranial doppler
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of 3% Minoxidil Lotion for Chest Hair Enhancement
Status: UNKNOWN
Conditions: Chest Hair Enhancement
Interventions: DRUG: 3 % minoxidil lotion|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Minimally Invasive Surgery Reduce Anxiety?
Status: COMPLETED
Conditions: Anxiety
Interventions: BEHAVIORAL: Spielberger's State-Trait Anxiety Inventory(STAI )|PROCEDURE: total laparoscopic hysterectomy(TLH)|PROCEDURE: total abdominal hysterectomy(TAH)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Reduction of Postoperative Gastrointestinal Dysmotility Following Total Laparoscopic Hysterectomy.
Status: COMPLETED
Conditions: Postoperative Passage of Flatus|Postoperative Bowel Movement
Interventions: DRUG: Colace 100Mg Capsule|DRUG: Miralax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 3 Study of LNK01001 Capsule in Subjects With Moderate to Severe Atopic Dermatitis.
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: LNK01001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Pillboxes on Medical Adherence
Status: COMPLETED
Conditions: Chronic Disease|Medication Adherence
Interventions: DEVICE: Standard off-the-shelf pillbox|DEVICE: Custom off-the-shelf pillbox|DEVICE: Custom designed and manufactured pillbox|BEHAVIORAL: Education & Training|BEHAVIORAL: Reflection on medication routines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Tenofovir in Patients of Reactivation of Hepatitis B Presenting as Acute on Chronic Liver Failure
Status: COMPLETED
Conditions: Acute on Chronic Liver Failure|Hepatitis B
Interventions: DRUG: Tenofovir disoproxil fumarate (TDF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure
Status: RECRUITING
Conditions: Acute Hypoxemic Respiratory Failure
Interventions: DEVICE: HFNC only|DEVICE: HFNC + CNEP10|DEVICE: HFNC + CNEP20|DEVICE: HFNC + CNEP30
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ASCEND GO-2: Study of RVT-1401 for the Treatment of Participants With Active, Moderate to Severe Graves' Ophthalmopathy ( GO )
Status: TERMINATED
Conditions: Graves' Ophthalmopathy (GO)
Interventions: DRUG: RVT-1401 (Administered via subcutaneous injection)|OTHER: Placebo (Administered via subcutaneous injection)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Treatment Study of Insulin-Like Growth Factor-1 (IGF-1) in Autism Spectrum Disorder
Status: TERMINATED
Conditions: Autism Spectrum Disorder
Interventions: DRUG: IGF-1|DRUG: Placebo/saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Research of BCMA-Targeted CAR-T in B Cell Malignancies
Status: UNKNOWN
Conditions: Leukemia|Lymphoma|Multiple Myeloma
Interventions: BIOLOGICAL: Anti-BCMA-CAR-transduced T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.
Status: COMPLETED
Conditions: Seizure Disorder, Partial
Interventions: DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Transcranial Direct Current Stimulation for TKR
Status: UNKNOWN
Conditions: Transcranial Direct Current Stimulation|Post Operative Pain
Interventions: DEVICE: apply tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Impact of Low Resistance Exercise Training on Quality of Life in Pulmonary Arterial Hypertension
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Arterial Hypertension|Frailty
Interventions: BEHAVIORAL: Low-Resistance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Photodynamic Therapy Using Verteporfin for Treatment of Chronic Central Serous Chorioretinopathy (CSC)
Status: COMPLETED
Conditions: Chronic Central Serous Chorioretinopathy
Interventions: PROCEDURE: Photodynamic Therapy with Verteporfin|DRUG: verteporfin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wheat Bread Study: Comparison of the Tolerance of Different Wheat Breads
Status: RECRUITING
Conditions: Non-celiac Gluten Sensitivity|Wheat Hypersensitivity
Interventions: OTHER: Wheat bread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Yoga Versus Passive Modality on Pain, Disability, Salivary Cortisol Concentrations, Brain- Derived Neurotropic Factor, Heart Rate Variability and Immune Functions Among Patients With Chronic Low Back Pain: A Randomized Controlled Trial
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: BEHAVIORAL: passive modality|BEHAVIORAL: Yoga treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Healthy.io Method Comparison & User Performance Study
Status: COMPLETED
Conditions: Urinary Tract Infection|Kidney Failure|Diabetes
Interventions: DEVICE: Dip.io Home Based Dipstick Analyzer|DEVICE: ACON U500 Mission® U500 Urine Analyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Extension Study of V72P13 to Evaluate the Safety, Tolerability and Immunogenicity of Novartis Meningococcal B Recombinant Vaccine When Administered as a Booster or as a Two-dose Catch-up to Healthy Toddlers
Status: COMPLETED
Conditions: Meningococcal Disease
Interventions: BIOLOGICAL: 1a - rMenB+OMV NZ and routine vaccines|BIOLOGICAL: 1b - rMenB+OMV NZ and routine vaccines|BIOLOGICAL: 2a - Routine and rMenB+OMV NZ vaccines|BIOLOGICAL: 2b - rMenB+OMV NZ and routine vaccines|BIOLOGICAL: 3a - rMenB+OMV NZ and routine vaccines|BIOLOGICAL: 3b - 1 dose of rMenB+OMV NZ plus routine infant vaccinations|BIOLOGICAL: 4a- rMenB+OMV NZ and routine vaccines|BIOLOGICAL: 4b - rMenB+OMV NZ and routine vaccines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Acupuncture as Adjunctive Therapy in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Acupuncture
Interventions: DEVICE: SEIRIN PYONEX Acupuncture Needles|OTHER: PYONEX Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Interest of the Presepsin Assay as a Biomarker of Bacterial Infection, in the Management of Newborns and Infants Under 3 Months of Age Admitted for Fever in Pediatric Emergency Service (Presepsin)
Status: TERMINATED
Conditions: Newborn Sepsis|Fever
Interventions: DIAGNOSTIC_TEST: Prespesin assay on PATHFAST analyser
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cryoneurolysis Outcome on Pain Experience (COPE) in Patients With Low-back Pain
Status: UNKNOWN
Conditions: Chronic Low-back Pain|Facet Joint Pain|Degeneration Lumbar Spine|Facet Joint Syndrome|Back Pain Lower Back Chronic
Interventions: PROCEDURE: Cryoneurolysis|PROCEDURE: Radiofrequency ablation|PROCEDURE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Diagnosis of Colorectal Cancer Based on a Non-invasive Metabolomics Profile
Status: RECRUITING
Conditions: Colorectal Cancer|Colorectal Adenoma|Colorectal Polyp|Healthy
Interventions: PROCEDURE: Colonoscopy|OTHER: Urine and FOBT collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: the Efficacy of Giomer Versus Sodium Fluoride in the Treatment of Hypersensitivity
Status: UNKNOWN
Conditions: Tooth Hypersensitivity
Interventions: DRUG: shofu PRG barrier coat|DRUG: Sodium fluoride varnish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chronotropic Incompetence in Patients With HFpEF
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: Static Handgrip|DRUG: Dexmedetomidine|DRUG: Glycopyrrolate|DRUG: Isoproterenol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Fixed Dose Combinations of Long-acting β2-agonist (LABA) and Inhaled Corticosteroid (ICS)
Status: COMPLETED
Conditions: COPD|COPD Exacerbation|Lung Diseases|Respiratory Disorders|Pulmonary Disease|Chronic Obstructive Lung Diseases|Chronic Obstructive Airway Disease
Interventions: DRUG: Roflumilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Three Dosage Levels of Swine Influenza Vaccine in Children Ages 3 to <9 Years, Adolescents 9 to <18 Years, Adults 18 to <65 Years and Elderly 65 Years and Older.
Status: COMPLETED
Conditions: Prophylaxis of A/H3N2v Influenza
Interventions: BIOLOGICAL: Swine Influenza
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Reactogenicity and Immunogenicity of Flublok Quadrivalent (Recombinant Influenza Vaccine,Seasonal Formulation)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Flublok® Quadrivalent Influenza Virus Vaccine|BIOLOGICAL: Fluarix Quadrivalent® Influenza Virus Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Dexamethasone and Dexmedetomidine as an Adjuvant to Spinal Anesthesia for Elective Caesarean Sections
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: Intrathecal dexamethasone|DRUG: Intrathecal dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Muscle Strengthening and Return-to-exercise Criteria After Anterior Cruciate Ligament Reconstruction (ACLR)
Status: RECRUITING
Conditions: Anterior Cruciate Ligament Injuries
Interventions: OTHER: Neuromuscular exercise program|OTHER: Institutional exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Bedside Respiratory Muscle Training in Stroke Patients
Status: COMPLETED
Conditions: Stroke|Rehabilitation|Breathing Exercise|Pneumonia|Respiration
Interventions: DEVICE: bedside respiratory muscle training|BEHAVIORAL: conventional stroke rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BCMA-targeted LCAR-BCDR Cells in Patients With Relapsed/Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Relapsed/Refractory Multiple Myeloma
Interventions: BIOLOGICAL: LCAR-BCDR cells product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-management of Chronic Mobility Limitations in MUHC Seniors
Status: COMPLETED
Conditions: Seniors With Mobility Limitations
Interventions: OTHER: Mobility self-management with Mentor|OTHER: Mobility self-management with guidebook
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short (5 Days) Versus Long (14 Days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Children
Status: COMPLETED
Conditions: Sinusitis
Interventions: DRUG: Amoxicillin-Potassium Clavulanate Combination|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fish Oil and Diet for the Treatment of Non-Alcoholic Steatohepatitis (NASH)
Status: TERMINATED
Conditions: Nonalcoholic Steatohepatitis (NASH)|Hepatic Steatosis
Interventions: DRUG: Omega-3-acid ethyl esters (Lovaza)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT