pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Assessment of Coagulation Factor Levels in Left Ventricular Device (LVAD )Patients Following Temporary Warfarin Reversal With Four Factor Prothrombin Complex Concentrate (4F-PCC)
Status: UNKNOWN
Conditions: Anticoagulation|Anticoagulation Reversal
Interventions: DRUG: four factor prothrombin complex concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Clinical Trial in Healthy Male Volunteers
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases
Interventions: DRUG: HMPL-011 tablets|DRUG: HMPL-011 capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Extension Study of Long-term Safety and Efficacy of Myozyme in Patients With Pompe Disease Who Were Previously Enrolled in Genzyme Sponsored Enzyme Replacement Therapy (ERT) Studies
Status: COMPLETED
Conditions: Pompe Disease Infantile-Onset|Glycogen Storage Disease Type II
Interventions: BIOLOGICAL: Myozyme
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effect of Flavor on ENDS Users' Experiences and Exposures
Status: COMPLETED
Conditions: Electronic Cigarette Use
Interventions: OTHER: Preferred Juul pod flavor (5% nicotine)|OTHER: Classic Tobacco Juul pod flavor (5% nicotine)|OTHER: Preferred flavor with HWL|OTHER: Preferred flavor, 3% nicotine|OTHER: Preferred flavor, 0% nicotine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neoadjuvant Tirellizumab Combined With Chemotherapy for Early Oral Squamous Cell Carcinoma(HNC-SYSU-004)
Status: RECRUITING
Conditions: Oral Cancer|PD-1
Interventions: DRUG: PD-1 with chemotherapy|PROCEDURE: upright surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Establishment of Genomic, Transcriptomic and Functional Characteristics of Tumor Cells in Hyperinflammatory Hemopathies
Status: NOT_YET_RECRUITING
Conditions: Monoclonal Gammopathy of Undetermined Significance|Multiple Myeloma|Waldenstrom Macroglobulinemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Varenicline for Nicotine Dependence Among Those With HIV/AIDS
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: DRUG: Varenicline|DRUG: Placebo|BEHAVIORAL: Smoking Cessation Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Uterine, Fetal Cerebral Doppler and Oligohydramnios to Predict Abnormal Heart Rate Tracings in Postterm Pregnancies
Status: COMPLETED
Conditions: Abnormality in Fetal Heart Rate or Rhythm|Ultrasound|Late Pregnancy
Interventions: DIAGNOSTIC_TEST: Ultrasound and Doppler ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Healthy Transitions in Late Stage Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: OTHER: Education|OTHER: Daily weight measurement and monitoring|OTHER: Universal Dietary education|OTHER: Medication review|OTHER: Focused advanced directive program|OTHER: Countdown to fistula program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Elemental Diet for Treatment of Inflammatory Bowel Disease in Patients With Chronic Granulomatous Disease
Status: ENROLLING_BY_INVITATION
Conditions: Chronic Granulomatous Disease|Inflammatory Bowel Disease
Interventions: OTHER: Neocate Splash
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S1222 Trial (Everolimus, Anastrozole and Fulvestrant) in Post-Menopausal Stage IV Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Fulvestrant|DRUG: Anastrozole|DRUG: Everolimus|DRUG: Placebo - Anastrozole|DRUG: Placebo - Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of Diffuse Large B-cell Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Refractory Diffuse Large B-cell Lymphoma
Interventions: DRUG: Rituximab Paclitaxel Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of BI 425809 Effect on Cognition and Functional Capacity in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: BI 425809 dose 1|DRUG: BI 425809 dose 2|DRUG: BI 425809 dose 3|DRUG: BI 425809 dose 4|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: ImmunoModulation by the Combination of Ipilimumab and Nivolumab Neoadjuvant to Surgery In Advanced or Recurrent Head and Neck Carcinoma
Status: COMPLETED
Conditions: Immunotherapy|Head and Neck Neoplasms
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Methicillin-sensitive Staphylococcus Aureus (MSSA)
Status: COMPLETED
Conditions: Osteoarticular Infection
Interventions: DRUG: association of RIFAMPIN + CLINDAMYCIN|DRUG: association of LEVOFLOXACIN+ CLINDAMYCIN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Colon Mucinous Adenocarcinoma|Colon Signet Ring Cell Adenocarcinoma|Lynch Syndrome|Stage IIA Colon Cancer AJCC v7|Stage IIB Colon Cancer AJCC v7|Stage IIC Colon Cancer AJCC v7
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Fluorouracil|OTHER: Laboratory Biomarker Analysis|DRUG: Leucovorin Calcium|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Oral Administration vs. Semi-continuous Intra-oral Administration of Levodopa/Carbidopa in Fluctuating Parkinsonian Patients
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Standard LD/CD|DRUG: Semi continuous intra-oral administration of LD/CD
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of an Immunotoxin on Activated Human Macrophages in Those With Allergic Rhinitis or Mild Intermittent Asthma
Status: TERMINATED
Conditions: Atopy|Rhinitis|Bronchial Asthma
Interventions: PROCEDURE: bronchoscopy, allergen/endotoxin instillation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Green Tea Lozenges for the Management of Dry Mouth
Status: COMPLETED
Conditions: Xerostomia|Sjogren Syndrome|Dry Mouth
Interventions: DIETARY_SUPPLEMENT: MighTeaFlow|DIETARY_SUPPLEMENT: Xylitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Anlotinib Hydrochloride Capsule Combined With Chemotherapy in Subjects With Squamous Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Squamous Non-small Cell Lung Cancer
Interventions: DRUG: Anlotinib|DRUG: Placebos|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Test the Safety and Immunogenicity of VARIVAX (2007 Process) (Study V210-057) (Completed)
Status: COMPLETED
Conditions: Varicella
Interventions: BIOLOGICAL: Varicella Virus Vaccine Live (2007 Process) (Oka/Merck)|BIOLOGICAL: Comparator: Varicella Virus Vaccine Live (1999 Process) (Oka/Merck)|BIOLOGICAL: Measles, Mumps, and Rubella Virus Vaccine Live (MMR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Pulsed-field and Radiofrequency Ablation on Platelet, Coagulation and Inflammation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Catheter ablation using SmartTouch radiofrequency ablation catheter|PROCEDURE: Catheter ablation using Farawave pulsed-field ablation catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Topical Doxycycline Gel on HbA1c in Patients With Type 2 Diabetes Mellitus(DM) ®
Status: COMPLETED
Conditions: Diabetes Mellitus With Periodontal Disease
Interventions: DRUG: Doxycycline Group|DRUG: placebo topical gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of The Clinical Acceptance of Soft Contact Lenses for Myopia Control
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: omafilcon A control lens|DEVICE: omafilcon A test lens 1|DEVICE: omafilcon A test lens 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Effect of the Formulations (Orally Disintegrating Tablet and Film-coated Tablet) on the Bioequivalence of Drug Rivaroxaban (Xarelto) at Dose of 15 mg in Japanese Healthy Male Adult Subjects
Status: COMPLETED
Conditions: Clinical Pharmacology
Interventions: DRUG: Rivaroxaban (BAY 59-7939, Xarelto) in ODT form|DRUG: Rivaroxaban (BAY 59-7939, Xarelto) in film-coated form
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Atrial Fibrillation: Chronic Beta-blocker Use Versus As-needed Rate Control Guided by Implantable Cardiac Monitor
Status: RECRUITING
Conditions: Atrial Fibrillation|Diastolic Dysfunction|HFpEF - Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: As needed pharmacological rate control with beta-blocker (metoprolol tartrate, metoprolol succinate) or calcium channel blocker (diltiazem, verapamil)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Web-Based Ventilator Management Educational Program for Clinicians (The Lung Injury Knowledge Network [LINK] Study)
Status: UNKNOWN
Conditions: Respiratory Distress Syndrome, Adult
Interventions: BEHAVIORAL: Web-Based Educational Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Ultrasound and X-ray in Detecting Articular Cartilage Calcification
Status: COMPLETED
Conditions: Chondrocalcinosis|Articular Cartilage Calcification
Interventions: PROCEDURE: Echography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Clinical Study for Inactivated Vaccine Against EV71
Status: COMPLETED
Conditions: Enterovirus 71 Human
Interventions: BIOLOGICAL: EV71 with adjuvant aluminium phosphate|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: FDFG Versus SMAS Flap After Superficial Parotidectomy; Evaluation of Functional and Esthetic Outcome
Status: COMPLETED
Conditions: Frey Syndrome
Interventions: PROCEDURE: FDFG|PROCEDURE: SMAS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaginal Compared With Intramuscular Progesterone for Prevention of Preterm Birth in High Risk Pregnant Women
Status: UNKNOWN
Conditions: Premature Birth
Interventions: DRUG: Vaginal progesterone|DRUG: Intramuscular progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of a Prime-boost Schedule of GSK Biologicals' Influenza Vaccine in Children
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza vaccine GSK1562902A Formulation 1|BIOLOGICAL: Influenza vaccine GSK1562902A Formulation 2|BIOLOGICAL: Havrix™|BIOLOGICAL: Havrix™ Junior
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: NOvel Immunotherapy Strategies for Advanced Triple Negative Breast Cancer (TNBC) Patients: TONIC-3 Trial
Status: RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Tiragolumab|DRUG: Atezolizumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Vonoprazan Compared to Lansoprazole in the Maintenance Treatment of Erosive Esophagitis
Status: COMPLETED
Conditions: Erosive Esophagitis
Interventions: DRUG: Vonoprazan|DRUG: Lansoprazole|DRUG: Vonoprazan Placebo|DRUG: Lansoprazole Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Nomogram to Predict the Postoperative Overall Survival in Gastrointestinal Cancer Patients
Status: COMPLETED
Conditions: Gastrointestinal Cancers - Stomach|Gastrointestinal Cancers - Colorectal|Prognosis|Survival Analysis|Nutrition Assessment
Interventions: OTHER: observation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Impact of Geriatric Assessment on the Treatment Plan of Elderly Patients With T2DM
Status: RECRUITING
Conditions: Type2diabetes|Frail Elderly Syndrome|Frailty|Geriatric Assessment
Interventions: BEHAVIORAL: Providing the physicians with a proposed glycated hemoglobin target
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of an Alkasite-based Restorative Material and Two Different Resin Composites
Status: RECRUITING
Conditions: Tooth Diseases
Interventions: DEVICE: an alkasite-based restorative material|DEVICE: hybrid resin composite|DEVICE: a highly filled flowable resin composite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Zero Suicide Plus KICKS
Status: COMPLETED
Conditions: Suicide|Suicidal Ideation|Suicidal Intention|Suicidal and Self-injurious Behavior
Interventions: BEHAVIORAL: Intergenerational Knowledge Sharing group|BEHAVIORAL: Support group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Eradication of Helicobacter Pylori on the Dyspeptic Symptoms
Status: COMPLETED
Conditions: Functional Dyspepsia|Helicobacter Pylori Infection
Interventions: DRUG: Omeprazole + Clarithromycin + Amoxycillin|DRUG: Omeprazole + placebo antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy in Walked Distance of Indacaterol vs Tiotropium in Women With COPD Secondary to Biomass (EMERALD)
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: indacaterol|DRUG: Tiotropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adding Lomustine to Chemotherapy in Older Patients With Acute Myelogenous Leukemia (AML), and Allogeneic Transplantation for Patients From 60 to 65 Years Old
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Lomustine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mivacurium 0.2 mg/kg in Young (18 - 40 Years) and Elderly (= 80 Years) Patients
Status: COMPLETED
Conditions: Onset Time of Mivacurium, Duration of Action of Mivacurium
Interventions: DRUG: Mivacurium
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of the Maternal Voice Combined With Lullaby to Reduce the Heel Puncture Pain in Preterm Infant
Status: COMPLETED
Conditions: Pain
Interventions: BEHAVIORAL: Maternal voice|BEHAVIORAL: Lullaby|BEHAVIORAL: Maternal voice combined with lullaby
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diet, Obesity and Genes (DiOGenes)
Status: COMPLETED
Conditions: Obesity|Metabolic Syndrome|Type 2 Diabetes|Cardiovascular Disease
Interventions: BEHAVIORAL: High or low Glycemic Index and high or low Protein Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Comparative Study of Sitagliptin,Vildagliptin and Saxagliptin
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin|DRUG: Vildagliptin|DRUG: Saxagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Full Length Parathyroid Hormone, PTH(1-84) or Strontium Ranelate on Bone Markers in Postmenopausal Women With Primary Osteoporosis (FP-006-IM)
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Full Length Parathyroid Hormone, PTH(1-84)|DRUG: Strontium Ranelate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Vessel-FFR Versus FFR in Intermediate Coronary Stenoses
Status: RECRUITING
Conditions: Coronary Artery Disease|Coronary Artery Stenoses
Interventions: DIAGNOSTIC_TEST: measurement of FFR|DIAGNOSTIC_TEST: measurement of Pd/Pa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cerebellar Neuromodulation to Enhance Fear Extinction and Predict Response to Exposure Therapy
Status: COMPLETED
Conditions: Anxiety Disorders|Social Phobia
Interventions: DEVICE: Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy Evaluation of Surfactant Administration Via Laryngeal Mask Airway
Status: UNKNOWN
Conditions: Respiratory Distress Syndrome, Newborn
Interventions: PROCEDURE: Use tracheal intubation for surfactant therapy|PROCEDURE: Use of Proseal laryngeal mask airway for surfactant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Prevention of Depression in the Workplace (e-pD-Work)
Status: ACTIVE_NOT_RECRUITING
Conditions: Depression
Interventions: BEHAVIORAL: e-predictD-Work intervention|OTHER: Brief psychoeducational messages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: AZD7442 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: AZD7442|BIOLOGICAL: Placebo|BIOLOGICAL: Remdesivir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Three Combination Chemotherapy Regimens in Treating Women With Stage I or Stage II Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: epirubicin hydrochloride|DRUG: mitoxantrone hydrochloride|DRUG: vinorelbine tartrate|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: APL93: Timing of CxT and Role of Maintenance
Status: COMPLETED
Conditions: Leukemia, Promyelocytic, Acute
Interventions: DRUG: ATRA|DRUG: ATRA and or Chemo as maintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label Trial of Acthar Gel in Subjects With Moderate to Severe Active Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Lupus Erythematosus Systemic Exacerbation
Interventions: DRUG: H.P. Acthar Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Coagulation Factor VIIa Marzeptacog Alfa (Activated) in Subjects With Hemophilia A or B
Status: TERMINATED
Conditions: Hemophilia A With Inhibitor|Hemophilia B With Inhibitor
Interventions: BIOLOGICAL: MarzAA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Residual Neuromuscular Blockade in Cardiac Surgery Patients
Status: WITHDRAWN
Conditions: Residual Neuromuscular Blockade
Interventions: DRUG: Sugammadex|DRUG: neostigmine/glycopyrolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 1/2 Study of FS118 in Patients With Advanced Malignancies
Status: TERMINATED
Conditions: Advanced Cancer|Metastatic Cancer|Squamous Cell Carcinoma of Head and Neck
Interventions: DRUG: FS118|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Fruit Juices Consumption on Postprandial Glycemic Responses and Satiety
Status: COMPLETED
Conditions: Potential Abnormality of Glucose Tolerance|Appetitive Behavior
Interventions: OTHER: Glucose as reference food|OTHER: Orange juice|OTHER: Mixed fruit juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Adolescent Depression Screening and Treatment in Mozambican Primary Care
Status: ENROLLING_BY_INVITATION
Conditions: Depression|Adolescent Behavior
Interventions: BEHAVIORAL: Group Interpersonal Therapy for Adolescents (IPT-AG)|BEHAVIORAL: Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Locoregional Administration of TIL and Lymphodepletion in Patients With Melanoma and Liver Metastases
Status: NOT_YET_RECRUITING
Conditions: Uveal Melanoma|Metastatic Cutaneous Melanoma
Interventions: DRUG: Autologous Tumor Infiltrating Lymphocytes|DRUG: Melphalan|DRUG: Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Antitumor Activity and Safety of Niraparib as Neoadjuvant Treatment in Participants With Breast Cancer
Status: COMPLETED
Conditions: Neoplasms, Breast
Interventions: DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Lacutamab in Peripheral T-cell Lymphoma
Status: RECRUITING
Conditions: Peripheral T Cell Lymphoma|Relapse/Recurrence
Interventions: DRUG: Lacutamab|DRUG: Gemcitabine|DRUG: Oxaliplatine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Elamrousy Modified Approach for Socket Shield Technique
Status: COMPLETED
Conditions: Implant Site Reaction|Tooth Extraction Status Nos|Dental Implant Failed
Interventions: PROCEDURE: Elamrousy Novel Approach for Immediate Implant Placement Using Socket Shield Technique|PROCEDURE: Immediate Implant Placement Using Socket Shield Technique alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Glucose Monitors for Children With Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Insulin-Dependent
Interventions: DEVICE: The GlucoWatch® G2™ Biographer (GW2B)|DEVICE: The Continuous Glucose Monitoring System (CGMS™)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individual Follow-up After Rectal Cancer - Focus on the Needs of the Patient
Status: COMPLETED
Conditions: Rectal Neoplasms
Interventions: BEHAVIORAL: Patient-led follow-up|OTHER: Standard follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: VASSTII: An Exploratory Clinical Study on a VASST IITreadmill System for Post Stroke Gait Rehabilitation.
Status: COMPLETED
Conditions: Stroke|Hemiplegic Gait
Interventions: DEVICE: VASST II treadmill
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Unexcitability Along the Ablation as an Endpoint for Atrial Fibrillation Ablation
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation|Catheter Ablation Strategies
Interventions: DEVICE: catheter based pulmonary vein isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy After Surgery in Treating Patients With Cancer of the Esophagus or Stomach
Status: COMPLETED
Conditions: Esophageal Cancer|Gastric Cancer
Interventions: DRUG: cisplatin|DRUG: paclitaxel|PROCEDURE: surgical procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Growth, Tolerance, and Safety Study of Healthy Term Infants Consuming a New Organic Cow's Milk-Based Infant Formula
Status: RECRUITING
Conditions: Healthy Growth
Interventions: OTHER: New Organic Infant Formula|OTHER: Commercial Organic Infant Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinical Trial of Thoracoscopic Lobecotmy Under Spontaneous Ventilating Anesthesia
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: PROCEDURE: spontaneous ventilation|PROCEDURE: intubated anesthesia with single-lung mechanical ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-FDG PET/MR Imaging for Differentiation of Serous From Non-Serous Pancreatic Cystic Neoplasms: A Pilot Study
Status: COMPLETED
Conditions: Pancreatic Cystic Neoplasms
Interventions: DIAGNOSTIC_TEST: PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Development of Technologies to Increase In-Seat Movement to Prevent Sitting-Acquired Pressure Injuries in Wheelchair Users
Status: COMPLETED
Conditions: Pressure Ulcer|Pressure Injury|Wheelchair
Interventions: BEHAVIORAL: Sensoria|BEHAVIORAL: AW-Shift
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Proof of Concept for All-ceramic Zirconia Resin Bonded Bridges for Canine, Premolar and Short Span Posterior Teeth
Status: COMPLETED
Conditions: Missing Teeth
Interventions: DEVICE: Zirconia resin bonded bridge
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of Golimumab in Subjects With Rheumatoid Arthritis That Are Methotrexate-naive
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Placebo injections|DRUG: Placebo capsules|DRUG: Methotrexate capsules|BIOLOGICAL: Golimumab 50 mg injections|BIOLOGICAL: Golimumab 100 mg injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Accelerating Post-exercise Muscle Glycogen Resynthesis in Humans: Impact of Combined Nutrient Intake and Intermittent Pneumatic Compression or Heat Therapy
Status: COMPLETED
Conditions: Muscle Recovery|Muscle Soreness|Glycogen Depletion
Interventions: DEVICE: Compression sleeve|DEVICE: Heat therapy|OTHER: Glycogen-depleting exercise session|OTHER: Nutrient Intake (beverage)|PROCEDURE: Skeletal muscle biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study To Describe The Safety, Tolerability, And Immunogenicity Of 13- Valent Pneumococcal Conjugate Vaccine Formulated In Multidose Vials When Given With Routine Pediatric Vaccines In Healthy Infants In India
Status: COMPLETED
Conditions: Vaccines
Interventions: BIOLOGICAL: 13vPnC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Orange Park Out-of-Hospital Quality Improvement Study for Improving CMS Sepsis Core Measures
Status: COMPLETED
Conditions: Sepsis|Emergency Medical Services|Quality Improvement|Shock, Septic|Fluid Therapy
Interventions: OTHER: Incorporation of Rapid Fluid Infusion Device in Prehospital Suspected Sepsis Protocol|OTHER: Conventional Prehospital Suspected Sepsis Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Short Course Glucocorticoid Treatment for PTSD
Status: COMPLETED
Conditions: Post-traumatic Stress Disorder
Interventions: DRUG: prednisone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Yoga and Aromatherapy on Salivary Hormone and Immune Function in Pregnant Women.
Status: COMPLETED
Conditions: Stress, Psychologic
Interventions: BEHAVIORAL: Aromatherapy massage|BEHAVIORAL: Yoga exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 131I-MIBG Alone VS. 131I-MIBG With Vincristine and Irinotecan VS131I-MIBG With Vorinostat
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: RADIATION: 131I-MIBG|DRUG: Vincristine|DRUG: Irinotecan|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selinexor in Combination With Immunomodulator （Thalidomide/Pomalidomide/Lenalidomide）in RRMM
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Selinexor|DRUG: Thalidomide|DRUG: Lenalidomide|DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Jaw Thrust on the Time to Successful Fiberoptic Pediatric Orotracheal Intubation During Residents Training Program
Status: RECRUITING
Conditions: Intubation
Interventions: PROCEDURE: jaw thrust|PROCEDURE: control (sub laxed jaw)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect and the Pharmacogenomics Study of Liraglutide in Obese Patients
Status: WITHDRAWN
Conditions: Obesity
Interventions: DRUG: Liraglutide|DRUG: Liraglutide;metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Classroom Training and SMS Supported Interventions Improving Foot Care and Self-Efficacy
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetic Foot Ulcer
Interventions: OTHER: Foot care training with virtual classroom|OTHER: Foot care training with SMS support|OTHER: Foot care training with virtual classroom and SMS support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Macintosh Blade Size for Endotracheal Intubation in Operative Rooms
Status: NOT_YET_RECRUITING
Conditions: Intubation Complication|Intubation; Difficult or Failed|Endotracheal Intubation
Interventions: DEVICE: Direct laryngoscopy using Macintosh blade
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Childhood Social Phobia
Status: COMPLETED
Conditions: Social Phobia
Interventions: BEHAVIORAL: Social Effectiveness Therapy for Children (SET-C)|DRUG: Fluoxetine|DRUG: Pill Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Azacitidine and Cisplatin in Patients With Advanced Lung or Head and Neck Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer|Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Azacitidine and Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NeoAdjuvant Theranostic Lutetium Study: The Nautilus Trial
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Arm A: 177Lu rhPSMA-10.1|DRUG: Arm B: 177Lu rhPSMA-10.1 plus Degarelix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mentors Offering Maternal Support (M-O-M-S™): A Prenatal Program for Decreasing Maternal Anxiety and Depression
Status: COMPLETED
Conditions: Anxiety Fear|Prenatal Depression|Infant, Low Birth Weight|Preterm Birth|Maternal
Interventions: BEHAVIORAL: Mentors Offering Maternal Support (M-O-M-S)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Women Hypertensive and Young-Renal Denervation
Status: RECRUITING
Conditions: Arterial Hypertension
Interventions: PROCEDURE: Arteriography and renal denervation|PROCEDURE: Arteriography without renal denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of XG-102 in Reduction of Post-cataract Surgery Intraocular Inflammation and Pain
Status: COMPLETED
Conditions: Inflammation|Pain|Cataract
Interventions: DRUG: XG-102|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Hyaluronic Acid Gel in the Prevention of Intrauterine Adhesions After Second Trimester Abortion
Status: UNKNOWN
Conditions: Placenta Retained|Uterine Diseases
Interventions: DEVICE: intrauterine self-cross-linked hyaluronic acid gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combating Dengue With Innovative, Paradigm-shift-Strategies: Early Dengue Surveillance in Adult Aedes Mosquitoes
Status: UNKNOWN
Conditions: Dengue
Interventions: OTHER: GOS trap and dengue NS1 antigen kit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: RIXUBIS PMS India (RIXUBIS PMS)
Status: COMPLETED
Conditions: Hemophilia B
Interventions: BIOLOGICAL: RIXUBIS: On-Demand|BIOLOGICAL: RIXUBIS: Prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Smart-TV Application for the Self Examination of the Distance Visual Acuity in Macular Edema Patients
Status: UNKNOWN
Conditions: Low Vision|Macular Edema|Refractive Errors
Interventions: DIAGNOSTIC_TEST: DDiVAT Testing|DIAGNOSTIC_TEST: Distance visual acuity assessment via ETDRS chart
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Different Bran-based Dietary Platforms on the Colon Metabolism in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Unmodified wheat bran|DIETARY_SUPPLEMENT: Wheat bran with reduced particle size|DIETARY_SUPPLEMENT: Destarched pericarp-enriched wheat bran|DIETARY_SUPPLEMENT: No wheat bran fraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multidisciplinary Study of Novel NMDA Modulation for Neurodegenerative Disorder
Status: RECRUITING
Conditions: Parkinson's Disease With Dementia
Interventions: DRUG: DAAOI-P|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A One-Year Study To Evaluate The Efficacy And Safety Of CP-690,550 For Patients With Moderate To Severe Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: CP-690,550|DRUG: CP-690,550|DRUG: Placebo/CP-690,550|DRUG: Placebo/CP-690,550
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing the Ischemic Preconditioning Effects of Ticagrelor and Clopidogrel in Humans
Status: TERMINATED
Conditions: Ischemic Preconditioning
Interventions: PROCEDURE: Coronary occlusion with balloon inflation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACURATE Neo™ Aortic Bioprosthesis for Implantation Using the ACURATE TA™ LP Transapical Delivery System in Patients With Severe Aortic Stenosis
Status: COMPLETED
Conditions: Aortic Stenosis
Interventions: DEVICE: ACURATE neo™ and ACURATE TA™ LP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: MRI Study of Changes in Blood-Brain/Tumor-Barrier Permeability in Patients With Brain Metastases During and After Radiotherapy
Status: COMPLETED
Conditions: Brain Metastases
Interventions: RADIATION: Single Fraction Stereotactic Radiosurgery (SRS)|RADIATION: Fractionated Whole Brain Radiation Therapy (WBRT)|RADIATION: Fractionated Stereotactic Radiation Therapy (FSRT)|DEVICE: Magnetic Resonance Imaging (MRI) Assessments
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PRF Treatment for Patients With Chronic Lumbosacral Radicular Pain Compared to Conventional Medical Management
Status: COMPLETED
Conditions: Lumbosacral Radicular Syndrome
Interventions: OTHER: Pulsed Radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study: fMRI Evaluation of Auricular PENFS for Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: Military Field Stimulator|OTHER: Standard Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Infliximab Biosimilar for Intravenous Drip Infusion 100 mg "Pfizer" Drug Use Investigation (Rheumatoid Arthritis)
Status: ACTIVE_NOT_RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Infliximab [infliximab biosimilar 3]
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Rehabilitation on Muscle Fibre Composition and Capillaries in Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: pulmonary rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pilot Study of Pregnenolone Augmentation Targeting Cognitive Symptoms in Persistently Symptomatic Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Pregnenolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Closer Look at the Effect of Dextrose on Postoperative Nausea and Vomiting
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: OTHER: Intravenous fluid|OTHER: D5LR or lactated ringers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: FemPulse Therapy First-in-Human Experience
Status: COMPLETED
Conditions: Urinary Bladder, Overactive
Interventions: DEVICE: Treament|DEVICE: Sham Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Amantadine in Treating Cognitive & Motor Impairments in Adolescents and Adults With Cerebral Palsy
Status: TERMINATED
Conditions: Cerebral Palsy
Interventions: DRUG: Amantadine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S9914: Combination Chemotherapy Plus Filgrastim in Untreated Extensive-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: paclitaxel|DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spironolactone Versus Amiloride as an Add on Agent in Resistant Hypertension
Status: WITHDRAWN
Conditions: Hypertension
Interventions: DRUG: spironolactone|DRUG: amiloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BCG Vaccination to Prevent COVID-19
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: Tice® BCG (for intravesical use) BCG LIVE strain of the BCG (Merck) vaccine|DRUG: Preservative-free saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Therapy With IgM-enriched Immunoglobulin With a Personalized Dose vs Standard Dose in Patients With Septic Shock.
Status: UNKNOWN
Conditions: Shock, Septic|Sepsis|Hypoglobulinemia
Interventions: DRUG: IgM-enriched polyclonal immunoglobulins titer-based treatment|DRUG: IgM-enriched polyclonal immunoglobulins Flat treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A First-in-human (FIH) Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (GIST) [Study ID: StrateGIST 1]
Status: RECRUITING
Conditions: Gastrointestinal Stromal Tumor (GIST)|Digestive System Disease|Gastrointestinal Diseases|Metastatic Cancer
Interventions: DRUG: IDRX-42|DRUG: IDRX-42
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transmission Reduction and Prevention With HPV Vaccination (TRAP-HPV) Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Human Papillomavirus Infection
Interventions: BIOLOGICAL: HPV vaccine, Gardasil 9|BIOLOGICAL: Hepatitis A vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment Protocol of Child SAA With the Injection of Mesenchymal Stem Cells（Umbilical Cord Derived）
Status: UNKNOWN
Conditions: Complications of Organ Transplant Stem Cells Umbilical Cord
Interventions: DRUG: MSC+ATG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Novel Anterior Rhinoscopic Scoring Scale to Predict Nasal Insertability Before Transnasal Endoscopy
Status: UNKNOWN
Conditions: Injury Due to Endoscopic Examination|Transnasal Endoscopy Induced Epistaxis|Transnasal Endoscopy Induced Nasal Pain
Interventions: PROCEDURE: anterior meatoscopy|PROCEDURE: Nasal sniff test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: WHO Drug Study for Buruli Ulcer - Comparison of SR8 and CR8
Status: COMPLETED
Conditions: Mycobacterium Ulcerans Infection
Interventions: DRUG: Clarithromycin Extended Release|DRUG: Streptomycin intramuscular injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT