pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Combination Chemotherapy in Treating Patients With Recurrent Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: FOLFIRI regimen|DRUG: FOLFOX regimen|DRUG: fluorouracil|DRUG: irinotecan hydrochloride|DRUG: leucovorin calcium|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Fluorouracil-Uracil and Leucovorin in Treating Elderly Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: leucovorin calcium|DRUG: tegafur-uracil
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Identification of Sodium Channel Fragments as Serum Biomarkers of a Traumatic Central Nervous System Injury
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injury|Spasticity, Muscle|Brain Injuries
Interventions: OTHER: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Clinical Trial of YMC017 in Hypertensive and Hypercholesterolemic Patients With Metabolic Syndrome
Status: TERMINATED
Conditions: Metabolic Syndrome
Interventions: DRUG: Telmisartan 40mg + Rosuvastatin 20mg|DRUG: Telmisartan 80mg + Rosuvastatin 20mg|DRUG: Telmisartan 40mg, 80 mg|DRUG: Rosuvastatin 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tacrolimus Ointment Interest (PROTOPIC ®) in the Maintenance Treatment of Severe Seborrheic Dermatitis
Status: COMPLETED
Conditions: Severe Seborrheic Dermatitis
Interventions: DRUG: Protopic (R)|DRUG: Mycoster (R)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Dried Miracle Berry on the Olfactory-gustative Perception in Malnourished Cancer Patients
Status: COMPLETED
Conditions: Cancer|Dysgeusia|Hypogeusia|Ageusia|Chemotherapy Effect|Malnutrition
Interventions: DIETARY_SUPPLEMENT: DMB lowest dose|DIETARY_SUPPLEMENT: DMB highest dose|DIETARY_SUPPLEMENT: Strawberry lyophilisate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing Gabapentin and Amitriptyline for the Treatment of Neuropathic Pain in Children and Adolescents
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Gabapentin|DRUG: Amitriptyline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Tolerability and Safety of NVA237 in Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: NVA237 50µg once daily|DRUG: Tiotropium 18µg once daily|DRUG: Flu/Sal|DRUG: NVA237 placebo + Tiotropium placebo.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rapid Pancreatic and Ovarian Screening MR Imaging With Motion Corrected T1, T2, and Advanced Diffusion Weighted Imaging for Patients With BRCA Mutation Who Undergo Screening Breast MRI
Status: ACTIVE_NOT_RECRUITING
Conditions: Screening Breast MRI in Patients Who Are BRCA Mutation Carriers
Interventions: DEVICE: MRI|BEHAVIORAL: Optional Screening Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Study of Recombinant Human Vascular Endothelial Inhibitor in Combination With PRaG for Advanced Refractory Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Advanced Solid Tumor|Refractory Tumor
Interventions: RADIATION: Radiotherapy|DRUG: PD-1/PD-L1 inhibitor|DRUG: Granulocyte-macrophage colony-stimulating factor subcutaneous injection|DRUG: Interleukin 2 subcutaneous injection|DRUG: Endostatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Local Infiltration Analgesia by Catheter in Postoperative Control Pain After Total Hip Replacement
Status: COMPLETED
Conditions: Musculoskeletal Pain|Hip Injuries
Interventions: DRUG: Bupivacaine hydrochloride|OTHER: Physiological Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of PT009 Compared to PT005 on COPD Exacerbations Over a 52-Week Period in Subjects With Moderate to Very Severe COPD (Sophos)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disorder
Interventions: DRUG: BFF MDI (PT009) 320/9.6 μg|DRUG: BFF MDI (PT009) 160/9.6 μg|DRUG: FF MDI (PT005) 9.6 μg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Crural Dissection in Sleeve Gastrectomy
Status: ENROLLING_BY_INVITATION
Conditions: Sleeve Gastrectomy
Interventions: PROCEDURE: Crura dissection|PROCEDURE: Sleeve gastrectomy|PROCEDURE: Hiatal hernia repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Chemoradiation Treatment for Advanced Cervical Cancer
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: DRUG: Pembrolizumab|RADIATION: Brachytherapy|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Gait and Balance in Children With Hemiplegic Cerebral Palsy: Gait Myoelectric Stimulator Study
Status: COMPLETED
Conditions: Hemiplegic Cerebral Palsy
Interventions: DEVICE: Gait Myoelectric Stimulator|OTHER: 5210
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MM-111 in Combination With Herceptin in Patients With Advanced Her2 Amplified, Heregulin Positive Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: MM-111 + Herceptin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of CO2 Rebreathing During Exercise With the Increasing Ventilation Assisted by NIV With a Dual-limb Circuit
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: dual-limb NIV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Omega 3 in Alcohol Use Disorder
Status: RECRUITING
Conditions: Alcohol Use Disorder, Severe
Interventions: DIETARY_SUPPLEMENT: Active Comparator: Omega-3|DIETARY_SUPPLEMENT: Placebo Comparator: olive oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized, Double-blind Study of Efficacy and Safety of Bexotegrast (PLN-74809) for Idiopathic Pulmonary Fibrosis
Status: RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: PLN-74809|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VelaShape III Device in Comparison to Cryolipolysis for Circumferential Reduction
Status: COMPLETED
Conditions: Abdominal Fat
Interventions: DEVICE: VelaShape III|DEVICE: CoolSculpt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Umbilical Cord Care for the Prevention of Colonization
Status: UNKNOWN
Conditions: Line Insertion Site|Central Line-associated Bloodstream Infection (CLABSI)
Interventions: DRUG: Povidone-Iodine|DRUG: Chlorhexidine gluconate|DRUG: Pluronic Cream|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of RRG001 Gene Therapy in Subjects With Neovascular Age-related Macular Degeneration (nAMD)
Status: RECRUITING
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: RRG001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effectiveness of Report Cards on the Quality of Care for Heart Attack and Heart Failure Patients
Status: COMPLETED
Conditions: Acute Myocardial Infarction|Congestive Heart Failure
Interventions: BEHAVIORAL: Publicly released hospital cardiac report cards
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Vytorin As Strategy To Reduce Dislipidemia In Adults (0653A-148)
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DRUG: ezetimibe (+) simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of a Novel Wearable Phototherapy System for the Management of Acute Burn Wounds
Status: UNKNOWN
Conditions: Burn Wound
Interventions: DEVICE: Low-Irradiance Monochromatic Biostimulation (LIMB) Device|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Study of Red Bull™ Sugar-Free Drink for Reduction of Fatigue in Prostate Cancer Patients Receiving LHRH Agonist Therapy
Status: COMPLETED
Conditions: Fatigue
Interventions: OTHER: Red Bull™ Sugar-Free Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Best Needle Size for FNA of Palpable Breast Mass:Randomised Controlled Study
Status: UNKNOWN
Conditions: Palpable Breast Mass
Interventions: PROCEDURE: FNA - fine needle aspiration|PROCEDURE: FNA - fine needle aspiration|PROCEDURE: FNA - fine needle aspiration|PROCEDURE: FNA - fine needle aspiration|PROCEDURE: FNA - fine needle aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Exercise Induced Pulmonary Hypertension in Systemic Sclerosis and Treatment With Ambrisentan
Status: COMPLETED
Conditions: Systemic Sclerosis|Shortness of Breath|Pulmonary Hypertension
Interventions: DRUG: Ambrisentan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maxillary Sinus Floor Augmentation With Bioss® and Enamel Matrix Derivative: Evaluation of Osteogenic Properties
Status: COMPLETED
Conditions: Patient Who is Requiring Bilateral Sinus Floor Elevation and Necessity of Dental Surgery
Interventions: OTHER: 7 patients will be recuting to received EMDOGAIM in left side|OTHER: 7 patients will be recuting to received EMDOGAIM in right side
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: IV Lidocaine on Postoperative Pain and QOR on Morbid Obese Patients Undergoing Bypass Surgery
Status: COMPLETED
Conditions: Pain|Obesity
Interventions: DRUG: Lidocaine Infusion|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Performance and Safety of Class IIb MD Celegyn® in VVA
Status: UNKNOWN
Conditions: Vulvovaginal Atrophy
Interventions: DEVICE: Celegyn®|DEVICE: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glucocorticoid Receptor Blockade With Mifepristone in Patients With Mild Adrenal Hypercortisolism
Status: COMPLETED
Conditions: Mild Hypercortisolism
Interventions: DRUG: Mifepristone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single and Multiple Ascending Dose Study to Assess the Safety, Tolerability and PK of ONO-2910 in Japanese and Caucasian Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: ONO-2910|DRUG: Placebo|DRUG: ONO-2910|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Efficacy of tDCS and tRNS to Improve Reading Skills in Children and Adolescents With Dyslexia
Status: ENROLLING_BY_INVITATION
Conditions: Developmental Dyslexia
Interventions: DEVICE: Active tDCS|DEVICE: Active tRNS|DEVICE: Sham tRNS or tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Different Injectable Formulations of LY3375880 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3375880|DRUG: Buffer Matrix (No LY3375880)|DEVICE: Autoinjector (AI)|DEVICE: Manual Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Anlotinib In Combination With PD-1/L1 Inhibitor As Sequential Therapy of Thoracic Radiotherapy After Induction Chemotherapy For Extensive-Stage Small Cell Lung Cancer:A Single Arm Study
Status: UNKNOWN
Conditions: NSCLC|Anlotinib|PD-1/L1 Inhibitor
Interventions: DRUG: Anlotinib In Combination With PD-1/L1 Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autoimmune Basis for Postural Tachycardia Syndrome
Status: ENROLLING_BY_INVITATION
Conditions: Postural Orthostatic Tachycardia Syndrome|Postural Tachycardia Syndrome|Tachycardia|Arrhythmias, Cardiac|Autonomic Nervous System Diseases|Orthostatic Intolerance|Cardiovascular Diseases|Primary Dysautonomias
Interventions: DRUG: phenylephrine|DRUG: isoproterenol|RADIATION: 25 micro-Ci of radiation|PROCEDURE: Posture study with blood samples|PROCEDURE: 24-hour heart rhythm and blood pressure monitoring|PROCEDURE: Quantitative Axonal Sudomotor Reflex Testing|PROCEDURE: Autonomic function tests|OTHER: Rebreathing test|OTHER: Assessment of splanchnic capacitance|PROCEDURE: microneurography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Misoprostol for Treatment of Fetal Death at 14-28 Weeks of Pregnancy
Status: COMPLETED
Conditions: Intrauterine Fetal Demise
Interventions: DRUG: Misoprostol|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of GL-ONC1, an Oncolytic Vaccinia Virus, in Patients With Advanced Peritoneal Carcinomatosis
Status: COMPLETED
Conditions: Peritoneal Carcinomatosis
Interventions: BIOLOGICAL: GL-ONC1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thorough QT/QTc Study to Evaluate the Effects of Ecopipam (EBS-101) on Cardiac Repolarization
Status: COMPLETED
Conditions: QT/QTc
Interventions: DRUG: Ecopipam Hydrochloride|DRUG: Moxifloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pneumatic Compression Versus Anti-thromboembolic Exercises for Patients Undergoing Total Hip Arthroplasty
Status: UNKNOWN
Conditions: Edema Leg
Interventions: DEVICE: PC Pneumatic compression|OTHER: AE Antithromboembolic exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined High Frequency Oscillation and Tracheal Gas Insufflation for Severe Acute Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Adult
Interventions: OTHER: High Frequency Oscillation and Tracheal Gas Insufflation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Chlorhexidine as the Hub Antiseptic to Prevent Catheter Related Infections in Newborn Infants
Status: UNKNOWN
Conditions: Catheterization
Interventions: DEVICE: 3.15% chlorhexidine as daily antiseptic on needleless access port
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Basel Postpartum Hypertension Cohort
Status: RECRUITING
Conditions: Postpartum Hypertension (PPHT)
Interventions: OTHER: Data collection for parameters of organ damage (cardiac and renal blood markers)|OTHER: Data collection for blood pressure (BP)|OTHER: Home-based blood pressure management (substudy)|OTHER: Biomarker Profiles (substudy)|OTHER: Data collection on patient reported outcomes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical, Inflammatory, and Economic Impact of Dextran 70 in Treating Spontaneous Bacterial Peritonitis
Status: TERMINATED
Conditions: Spontaneous Bacterial Peritonitis
Interventions: DRUG: Dextran 70|BIOLOGICAL: human albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maternal and Neonatal Outcomes of the Use of Vasopressors to Treat Hypotension During Spinal Anesthesia for Cesarean
Status: WITHDRAWN
Conditions: Preeclampsia|Pregnancy Toxemias
Interventions: DRUG: Metaraminol|DRUG: Ephedrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Act in Time -Implementation of Health Promotive Work-way in Primary Care Setting (AcTi)
Status: ACTIVE_NOT_RECRUITING
Conditions: Health Knowledge, Attitudes, Practice
Interventions: BEHAVIORAL: health promotive work-way
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Evaluate Efficacy and Safety of PF-04965842 in Subjects Aged 12 Years And Older With Moderate to Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: PF-04965842 100 mg|DRUG: PF-04965842 200 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Mw Vaccine in Treatment of Severe Sepsis
Status: COMPLETED
Conditions: Severe Sepsis|Septic Shock|Immune Modulation
Interventions: DRUG: Mw, 0.3ml x three days sc|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Multistrain Probiotic on Metformin Tolerance and Efficacy With Microbiota and Stool Metabolome in Insulin-resistant Women - a 12-week Randomized, Placebo-controlled, Double-blind Study
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: the group GS (probiotic)|DIETARY_SUPPLEMENT: the group GP (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Embozene Microspheres for Uterine Fibroid Embolization
Status: UNKNOWN
Conditions: Uterine Fibroids
Interventions: PROCEDURE: Uterine Fibroid Embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Patients With Newly Diagnosed BPDCN
Status: ACTIVE_NOT_RECRUITING
Conditions: Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
Interventions: DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ChemoRadiation And Tislelizumab for Esophageal/EGJ Cancer
Status: WITHDRAWN
Conditions: Esophageal Cancer|Esophagogastric Junction Cancer
Interventions: DRUG: Intravenous Tislelizumab|DRUG: Chemotherapy|RADIATION: Fractionated radiation|PROCEDURE: Esophagectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Lunch Study: the Combined Effects of Food Texture and Energy Density on Intake
Status: COMPLETED
Conditions: Satiation
Interventions: OTHER: Thin/Low Energy|OTHER: Thin/High Energy|OTHER: Thick/Low Energy|OTHER: Thick/High Energy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Effect of Severe Renal Impairment on the Single-dose Pharmacokinetics of Odalasvir
Status: COMPLETED
Conditions: Renal Insufficiency
Interventions: DRUG: Odalasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bioequivalence Evaluation of Two Fixed-dose Combination of Lisinopril 10mg/Levamlodipine Besylate 5mg in Healthy Chinese Subjects
Status: COMPLETED
Conditions: Therapeutic Equivalency
Interventions: DRUG: compound lisinopril tablet|DRUG: compound lisinopril tablet(Lisonorm®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Intravenous Lidocaine During Sedation for Colonoscopy.
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: Lidocaine|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SYMPHONY-2, A Trial to Examine Combination of Tazemetostat With Rituximab in Subjects With Relapsed/Refractory Follicular Lymphoma
Status: TERMINATED
Conditions: Follicular Lymphoma
Interventions: DRUG: Tazemetostat|COMBINATION_PRODUCT: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of V940 Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: V940|BIOLOGICAL: Pembrolizumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Photoaging Mobile App Promoting Poster Campaign for Preventing Smoking in Secondary Schools
Status: UNKNOWN
Conditions: Tobacco Addiction|Smoking Related Diseases|Adolescent Smoking
Interventions: BEHAVIORAL: Photoaging mobile app promoting poster campaign.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety of Vismodegib in Combination With Ruxolitinib for the Treatment of Intermediate- or High-Risk Myelofibrosis (MF)
Status: COMPLETED
Conditions: Myelofibrosis
Interventions: OTHER: Placebo|DRUG: Ruxolitinib|DRUG: Vismodegib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Characterizing Late-season Influenza Vaccine Responses to Compare the 2023 and 2024 Vaccine Formulations
Status: ACTIVE_NOT_RECRUITING
Conditions: Influenza A
Interventions: BIOLOGICAL: Influenza Fluzone vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Tuberculosis
Interventions: DRUG: Isoniazid|DRUG: Rifampicin|DRUG: Pyrazinamide|DRUG: Ethambutol|DRUG: Bedaquiline|DRUG: Pretomanid|DRUG: Linezolid|DRUG: TBI-223|DRUG: Sutezolid|DRUG: TBI-223|DRUG: Sutezolid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study to Evaluate Gadavist (Gadobutrol) as Contrast Agent in Magnetic Resonance Imaging (MRI) of Brain or Spine Diseases in Chinese Patients
Status: COMPLETED
Conditions: Central Nervous System Diseases
Interventions: DRUG: Gadobutrol (Gadavist, Gadovist, BAY86-4875)|DRUG: Magnevist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 1, Randomized, Controlled, Observer-blinded Trial to Evaluate the Safety and Immunogenicity of a Multivalent Pneumococcal Conjugate Vaccine in Healthy Adults Aged 18 to 49 Years
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: Multivalent|BIOLOGICAL: Tdap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 2 Study of ELX-02 in Patients With Nephropathic Cystinosis
Status: TERMINATED
Conditions: Genetic Disease|Nonsense Mutation|Cystinosis
Interventions: DRUG: ELX-02
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Intravenous HRS-8427 in the Treatment of Adults With Complicate Urinary Tract Infection, Including Acute Pyelonephritis
Status: NOT_YET_RECRUITING
Conditions: Patients With Complicated Urinary Tract Infection(cUTI), Including Acute Pyelonephritis(AP)
Interventions: DRUG: HRS -8427|DRUG: Imipenem and Cilastatin Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COVID19 and Physical and Emotional Wellbeing of HCP
Status: COMPLETED
Conditions: Mental Health
Interventions: OTHER: Questionnaire including validated tools such as Patient Health Questionnaire (PHQ-9), the 7-item Generalised Anxiety Disorder (GAD- 7), the 7-item insomnia severity index|OTHER: Questionnaire, same tools as before, with inclusion of PCL5 questionnaire too.|OTHER: Informed consent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lu-177-DOTATATE (Lutathera) in Therapy of Inoperable Pheochromocytoma/ Paraganglioma
Status: RECRUITING
Conditions: Pheochromocytoma|Paraganglioma|Neuroendocrine Tumors|Neuroendocrine Neoplasms
Interventions: DRUG: Lu-177-DOTATATE|DRUG: Ga-68-DOTATATE|DRUG: F-18-FDG|DRUG: Amino Acid solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contribution of Actigraphy for the Evaluation of Elbow Range of Motion in the Joint Assessment in Gerontology
Status: UNKNOWN
Conditions: Geriatric Disorder
Interventions: DEVICE: Assessment with inclinometer|DEVICE: Assessment with actigraph
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate Flexible Dose of Paliperidone Extended Release (ER) and Clinical Response in Participants With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Paliperidone ER
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NKG2D/CLDN18.21 CAR-T(KD-496) in the Treatment of Advanced NKG2DL+/CLDN18.2+ Solid Tumor
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer|Pancreatic Cancer|Solid Tumor
Interventions: BIOLOGICAL: KD-496
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnesium Treating Subarachnoid Hemorrhage Vasospasm
Status: UNKNOWN
Conditions: Subarachnoid Hemorrhage, Aneurysmal|Cerebral Vasospasm
Interventions: DRUG: Magnesium sulfate|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Support for Transgender and Non-Binary Individuals Seeking Vaginoplasty Study
Status: NOT_YET_RECRUITING
Conditions: Gender Affirmation Surgery|Perioperative Care|Transgender Health
Interventions: OTHER: STRIVE Peer Support Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: COMParison of the EffecT of dEvice Closure in Alleviating Migraine With PFO (COMPETE-2)
Status: RECRUITING
Conditions: Migraine|Patent Foramen Ovale
Interventions: DEVICE: PFO device closure|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Mobile Technology for Intensive Training in Medication Management
Status: COMPLETED
Conditions: Sickle Cell Disease|Thalassemia
Interventions: BEHAVIORAL: Video recording|BEHAVIORAL: Medication Administration Log|BEHAVIORAL: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Prolonged Daily Temozolomide for Low-Grade Glioma
Status: COMPLETED
Conditions: Glioma|Astrocytoma|Oligodendroglioma
Interventions: DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Ganglionated Plexi Activity in Patients With Different Forms of Atrial Fibrillation Guided by SUMO Technology
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DEVICE: Cardiac CT|PROCEDURE: Ablation Procedure|DEVICE: D-SPECT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propofol Versus Midazolam as Premedication for Preterm Neonates With Respiratory Distress Syndrome (RDS)
Status: UNKNOWN
Conditions: Respiratory Distress Syndrome
Interventions: DRUG: propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial on SBRT After Incomplete TAE or TACE Versus Exclusive TAE or TACE For Treatment of Inoperable HCC
Status: TERMINATED
Conditions: Hepatocellular Carcinoma
Interventions: RADIATION: SBRT|PROCEDURE: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Intracavity Electrocardiogram Positioning Technique in PICC
Status: UNKNOWN
Conditions: Patients Requiring Peripherally Inserted Central Venous Catheters
Interventions: DEVICE: PICC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Palbociclib in Combination With Chemotherapy in Pediatric Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia (RELPALL2)
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia, Pediatric|Relapsed Acute Lymphoblastic Leukemia|Refractory Acute Lymphoblastic Leukemia
Interventions: DRUG: Palbociclib|DRUG: Dexamethasone|DRUG: Bortezomib|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Triple Combination Therapy Study of Boceprevir, Pegasys and Copegus in Previously Untreated Patients With Genotype 1 Chronic Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: boceprevir|DRUG: peginterferon alfa-2a [Pegasys]|DRUG: peginterferon alfa-2a [Pegasys]|DRUG: ribavirin (Copegus]|DRUG: ribavirin (Copegus]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of PET Scan on the Curative Strategy of Colo-rectal Cancers : A Randomized Study
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: OTHER: semi-annual systematic PET-TDM|OTHER: PET-TDM for current indication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Green Tea Effect on Anthropometric, Oxidation and Inflammation Parameters in Physically Active vs. Sedentary Elders
Status: COMPLETED
Conditions: Aging
Interventions: DIETARY_SUPPLEMENT: Four green tea bags per day for 12 weeks|OTHER: 4 daily placebo tea bags for 12 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pain Relief After Colorectal Surgery: Spinal Combined With Painbuster® vs Painbuster® Alone.
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: PROCEDURE: Spinal and infusion of local anaesthetic|PROCEDURE: Continuous infusion of local anaesthetic|DRUG: Bupivacaine|DRUG: Diamorphine|DEVICE: A Painbuster® catheter|DEVICE: 25G Whitacre needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ideal Drainage Output of Post-operative Neck Suction Drain
Status: WITHDRAWN
Conditions: Head and Neck Neoplasms|Drain Site Complication|Neck Dissection
Interventions: OTHER: Suction drain removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intact Vagal Innervation for and Glucagon-like Peptide-1 (GLP-1) Effects
Status: UNKNOWN
Conditions: Vagotomy, Truncal
Interventions: DRUG: Dipeptidyl peptidase 4 (DPP 4) inhibitor|OTHER: oral glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Envarsus on the Effect of Total Tacrolimus Dose/Trough Level Ratio on Renal Function (eGFR) in Kidney Transplantation
Status: COMPLETED
Conditions: Renal Transplant Rejection|Kidney Transplant Failure and Rejection
Interventions: DRUG: Tacrolimus Extended Release Oral Tablet|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy in Treating Patients With Previously Untreated Stage II or Stage III Esophageal Cancer That Can Be Removed By Surgery
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: Docetaxel|DRUG: Floxuridine|DRUG: Leucovorin|DRUG: Oxaliplatin|GENETIC: Microarray analysis|GENETIC: reverse transcriptase-polymerase chain reaction|PROCEDURE: Conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dual-focus Soft Contact Lenses for Controlling Rapid Progressive Myopia in Young Adults
Status: NOT_YET_RECRUITING
Conditions: Myopia
Interventions: DEVICE: MiSight® 1 day soft contact lenses|DEVICE: Proclear® 1 day soft contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term Safety Follow up of Haematopoietic Stem Cell Gene Therapy for the Wiskott Aldrich Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Wiskott-Aldrich Syndrome
Interventions: GENETIC: Autologous CD34+ cells transduced with WASP lentiviral vector
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study With Lu AF87908 in Healthy Participants and Participants With Alzheimer's Disease
Status: COMPLETED
Conditions: Healthy|Alzheimer Disease
Interventions: DRUG: Lu AF87908|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Genetically Modified T-Cells Followed by Aldesleukin in Treating Patients With Stage III-IV Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Melanoma|Stage III Cutaneous Melanoma AJCC v7|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7
Interventions: BIOLOGICAL: Aldesleukin|DRUG: Cyclophosphamide|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: NGFR-transduced Autologous T Lymphocytes|BIOLOGICAL: TGFbDNRII-transduced Autologous Tumor Infiltrating Lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Daily Hemodialysis With Low Dialysate Flux in Unscheduled Patients With Kidney Injury Admitted to Hemodialysis
Status: TERMINATED
Conditions: Acute Kidney Injury|Kidney Failure, Chronic
Interventions: DEVICE: Hemodialysis with low dialysate flow|DEVICE: Conventional triweekly high-flow hemodialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of a New Type of Whole Blood Coagulation Time Measurement in Evaluating the Hypercoagulable State of Malignant Tumors
Status: RECRUITING
Conditions: Neoplasm Metastasis|Blood Coagulation Disorder With Shortened Coagulation Time (Disorder)|Venous Thromboembolism
Interventions: DIAGNOSTIC_TEST: CGT test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Analysis of Oral Mucositis in Patient's Undergoing Melphalan Conditioning and Autologous Stem Cell Transplant
Status: WITHDRAWN
Conditions: Mucositis|Multiple Myeloma|Amyloidosis|Oral Mucositis
Interventions: OTHER: Melphalan kinetic study|GENETIC: Oral bacterial study|GENETIC: Gene expression study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ciliation and Mucus Rheology Parameters Determined Via Air-liquid-interface Cell Cultures in Non-smoking, Smoking, COPD and Asthmatic Patients
Status: TERMINATED
Conditions: Pulmonary Disease, Chronic Obstructive|Asthma|Smoking
Interventions: PROCEDURE: Bronchial Biopsy|OTHER: ALI culture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Intravenous Lidocaine on Pain After Thyroidectomy
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Intravenous lidocaine injection|DRUG: Intravenous normal saline injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate Formation of IUAs After Third-generation Endometrial Ablation, With and Without Intrauterine Adhesion Barrier
Status: COMPLETED
Conditions: Asherman Syndrome|Intrauterine Adhesion
Interventions: DEVICE: Womed Leaf
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Port Wine Stains Treatment Matrix RF Study
Status: COMPLETED
Conditions: Port Wine Stains
Interventions: DEVICE: Matrix RF|DEVICE: Matrix RF followed by Pulse Dye Laser|DEVICE: Pulse Dye Laser followed by Matrix RF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: 99mTc-3PRGD2 SPECT/CT in Rheumatoid Arthritis Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: 99mTc-3PRGD2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Pharmacokinetics, Safety,and Efficacy of Omacetaxine Given Subcutaneously as a Fixed Dose in Patients With Chronic Phase (CP) or Accelerated Phase (AP) Chronic Myeloid Leukemia (CML) (Referred to as the SYNSINCT Study)
Status: TERMINATED
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Omacetaxine mepesuccinate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Expression of Sodium-glucose Co-transporter 2 in Human Heart
Status: NOT_YET_RECRUITING
Conditions: Aortic Valve Stenosis
Interventions: BIOLOGICAL: Myocardium biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-minors' Adjusted Version
Status: UNKNOWN
Conditions: FAP-Familial Adenomatous Polyposis
Interventions: DRUG: Erythromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Removable GORE VIABIL® Biliary Endoprosthesis for Treatment of Benign Biliary Strictures
Status: COMPLETED
Conditions: Biliary Strictures
Interventions: DEVICE: GORE® VIABIL® Biliary Endoprosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Adjunctive Antiplatelet Therapy Prior to Primary PCI in Patients With STEMI
Status: TERMINATED
Conditions: Myocardial Infarction
Interventions: DRUG: placebo|DRUG: PRT060128 Potassium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physiological Reconditioning Program Administered Remotely in Patients Undergoing Transcatheter Aortic Valve Replacement: A Pilot Study
Status: UNKNOWN
Conditions: Frailty|Transcatheter Aortic Valve Replacement|Rehabilitation
Interventions: OTHER: Remotely administered physiological reconditioning program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Disclosing Dementia Risk Based on Plasma Phosphorylated Tau
Status: RECRUITING
Conditions: Alzheimer Disease|Mild Cognitive Impairment
Interventions: BEHAVIORAL: Plasma p-tau risk disclosure|BEHAVIORAL: Standard risk disclosure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Brigatinib Plus Chemotherapy or Local Consolidation Therapy in ALK Positive Advanced Non-small Cell Lung Cancer (BrightStar-2)
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Brigatinib|DRUG: Carboplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development, Implementation and Evaluation of an Individual Decision Aid in Swedish Cancer Screening Programs
Status: RECRUITING
Conditions: Neoplasm, Colorectal|Neoplasm, Breast|Neoplasm, Ovarian
Interventions: DEVICE: Individual decision aid (iDA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Gemcitabine and Docetaxel in Treating Patients With Recurrent Stage III or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: docetaxel|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: [C-11]NPA PET-amphetamine in Cocaine Use Disorders
Status: RECRUITING
Conditions: Cocaine Use Disorder
Interventions: RADIATION: Baseline [C-11]NPA PET Scan|DRUG: d-amphetamine|RADIATION: Post-amphetamine [C-11]NPA PET Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Febuxostat Versus Allopurinol on Hepatic Steatosis in MAFLD Patients
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease|Hyperuricemia
Interventions: DRUG: Allopurinol (100 mg/day) plus lifestyle intervention|DRUG: Febuxostat 40 mg plus lifestyle intervention|BEHAVIORAL: Life style intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correlation Between Intraoperative Tourniquet Use and Limb pH, Functional Measures and Patient-reported Outcomes After Ankle Fracture Surgery
Status: UNKNOWN
Conditions: Ankle Fractures|Ankle Fracture - Lateral Malleolus|Ankle Fracture, Bimalleolar|Ankle Fracture, Trimalleolar|Ankle Fracture - Medial Malleolus|Maisonneuve's Fracture|Syndesmotic Injuries|Fibula Fracture
Interventions: PROCEDURE: Tourniquet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Vitamin K2 Status of Calcium-based Stone Formers
Status: ACTIVE_NOT_RECRUITING
Conditions: Kidney Calculi|Calcium Oxalate Kidney Stones|Vitamin K 2|Human|Kidney Stone|Calcium Oxalate Urolithiasis|Calcium Phosphate Urolithiasis|Nephrolithiasis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p