pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of MabThera (Rituximab) in Patients With Advanced Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: rituximab [MabThera/Rituxan]|DRUG: Standard chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cabozantinib in Combination With Atezolizumab for the Treatment of Patients With Locally Advanced, Metastatic, or Unresectable Adrenal Cortical Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Adrenal Cortex Carcinoma|Adrenal Cortical Carcinoma|Stage III Adrenal Cortex Carcinoma|Stage IV Adrenal Cortex Carcinoma AJCC v8|Unresectable Adrenal Cortex Carcinoma
Interventions: BIOLOGICAL: Atezolizumab|PROCEDURE: Biospecimen Collection|DRUG: Cabozantinib S-malate|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Laparoscopic Sleeve Gastrectomy and Roux-Y-gastric Bypass in the Treatment of Morbid Obesity
Status: COMPLETED
Conditions: Morbid Obesity
Interventions: PROCEDURE: sleeve gastrectomy|PROCEDURE: Roux-Y-gastric bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of a Dynamic Web-Based Visualization of Community Immunity
Status: COMPLETED
Conditions: Vaccine-Preventable Diseases
Interventions: BEHAVIORAL: herdimm|BEHAVIORAL: guardianmeasles|BEHAVIORAL: theotheredmundmeasles|BEHAVIORAL: sbsnewsgeneric|BEHAVIORAL: publichealthagencycanadaflu|BEHAVIORAL: robertkochgeneric
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: UTD1 Combined With Capecitabine in Metastatic HER2-negative Breast Cancer Patients With Brain Metastases
Status: RECRUITING
Conditions: Metastatic HER2 Negative Breast Carcinoma|Brain Metastases|Capecitabine|UDT1
Interventions: DRUG: UTD1 combined with capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Splenectomy on the Efficacy of Targeted Therapy and Immunotherapy in Unresectable HCC Patients With Cirrhotic Portal Hypertension
Status: RECRUITING
Conditions: Unresectable Hepatocellular Carcinoma
Interventions: COMBINATION_PRODUCT: Splenectomy+Targeted therapy+ Immunotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Erector Spinae Plane Block Versus Paravertebral Block for Analgesia After Cardiac Surgery (PEPS)
Status: UNKNOWN
Conditions: Pain Syndrome|Analgesia|Anesthesia, Local
Interventions: PROCEDURE: Ultrasound-guided Bilateral Paravertebral Block performed with a 20 ml injection of ropivacapine 3,75 mg/ml/side|PROCEDURE: Ultrasound-guided Bilateral Erector Spinae plane Block performed with a 20 ml injection ropivacaine 3,75 mg/ml/side
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma
Status: RECRUITING
Conditions: Glioblastoma|Glioblastoma Multiforme|Glioma|GBM|Glioma, Malignant|Glioblastoma Multiforme of Brain
Interventions: DRUG: Niraparib|RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BE Study of Naftifine HCL
Status: COMPLETED
Conditions: Tinea Pedis
Interventions: DRUG: Naftifine hydrochloride 2%|DRUG: Placebo|DRUG: Naftin® 2% (Naftifine hydrochloride 2%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Feasibility of a Stepped-care Approach to Treating Adolescents With Binge and Loss of Control Eating
Status: TERMINATED
Conditions: Overweight and Obesity|Pediatric Obesity|Eating, Binge
Interventions: BEHAVIORAL: Pathways to Health|BEHAVIORAL: Be4U
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surface Treatment of the Dental Implant on the Osseointegration
Status: COMPLETED
Conditions: Dental Implants|Surface Treatment
Interventions: OTHER: Aqua alvim CM, neodent implant (Test)|OTHER: Neoporous alvim CM, neodent implant (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multiple Dose Study to Investigate Safety, Tolerability and Pharmacokinetics of TBN
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DRUG: Tetramethylpyrazine nitrone (TBN) tablet / Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Nutritional Supplementation With HMB Enhance Muscle Quality in Sarcopenic Surgical Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Sarcopenia|Frailty
Interventions: DIETARY_SUPPLEMENT: Ensure Plus Advance
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Epoetin Alfa and Epoetin Omega in Anemic Dialysis Patients:Results of Efficacy Trial
Status: COMPLETED
Conditions: End Stage Renal Disease|Renal Anemia|Regular Dialysis Treatment
Interventions: DRUG: Epoetin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Long-term Varenicline Treatment for Smoking Cessation
Status: COMPLETED
Conditions: Smoking
Interventions: DRUG: varenicline|DRUG: varenicline|BEHAVIORAL: Individual smoking cessation counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect on Blood Chemistry and Inflammatory Marker of Omega-3 Enriched Total Parenteral Nutrition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Combiflex® lipid peri|DRUG: Winuf® peri
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Performance of DKL Crosslinked Sodium Hyaluronate 23 Dermal Filler for Improvement of NLF Appearance
Status: COMPLETED
Conditions: Aging, Premature
Interventions: DEVICE: DKL crosslinked sodium hyaluronate 23|DEVICE: Juvéderm Volift™ with lidocaine (Allergan, Inc)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Test Efficacy Study on the Recommended Antimalarial Drugs in the Democratic Republic of the Congo
Status: RECRUITING
Conditions: Uncomplicated Plasmodium Falciparum Malaria
Interventions: DRUG: Artesunate-amodiaquine|DRUG: Artemether-lumefantrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ZG2001 in Participants With KRAS Mutated Advanced Solid Tumours
Status: RECRUITING
Conditions: Solid Tumor|KRAS Mutation-Related Tumors
Interventions: DRUG: ZG2001 Tosilate Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Tildrakizumab on Epigenetic Age
Status: COMPLETED
Conditions: Psoriasis|Aging|Epigenetic Disorder|Inflammation; Skin
Interventions: BIOLOGICAL: TILDRAKIZUMAB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Lanreotide Versus Placebo for Treatment of Patients With Digestive Fistulae
Status: COMPLETED
Conditions: Digestive Fistulae
Interventions: DRUG: Lanreotide microparticles|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Sequential Combination of the Anti-cancer Drugs Olaparib Followed by Adavosertib (AZD1775) in Patients With Advanced Solid Tumors With Selected Mutations and PARP Resistance, STAR Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm|Refractory Malignant Solid Neoplasm|Unresectable Malignant Solid Neoplasm
Interventions: DRUG: Adavosertib|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Animated Cartoon-aided Teaching of Intranasal Corticosteroid Allergic Rhinitis
Status: COMPLETED
Conditions: Asthma|Allergic Rhinitis
Interventions: OTHER: score before teaching|OTHER: score immediately after teaching|OTHER: score 3 months after teaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Somatropin Treatment to Final Height in Turner Syndrome
Status: COMPLETED
Conditions: Turner Syndrome
Interventions: DRUG: Somatropin|DRUG: Ethinyl estradiol|DRUG: Medroxyprogesterone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electro-Acupuncture Treatment in Patients With Osteoarthritis Of The Knee (EATOAK)
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Regorafenib With Low-dose Chemotherapies and Aspirin Followed by Standard Chemotherapies in Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: OTHER: quality of life questionnaires|PROCEDURE: Blood sample|DRUG: Regorafenib|DRUG: Metronomic chemotherapies|DRUG: Aspirin|DRUG: Bevacizumab|DRUG: FOLFIRI or FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Low-intensity Excoporeal Shock Wave Therapy (LiESWT) on Women With Pelvic Floor Dysfunction
Status: UNKNOWN
Conditions: Overactive Bladder|Stress Incontinence|Interstitial Cystitis|Female Sexual Dysfunction
Interventions: DEVICE: "Storz Medical" Extracoporeeal Shock Wave Therapy System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The PEERLESS Study
Status: COMPLETED
Conditions: Pulmonary Embolism|Pulmonary Thrombo-embolism
Interventions: DEVICE: Catheter-Directed Thrombolysis|DEVICE: FlowTriever System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effect of Movement Mobilization Concept on Sensory, Pain, Muscle Activation in Patients With Knee Osteoarthritis
Status: RECRUITING
Conditions: Osteo Arthritis Knee|Movement Disorders|Physical Disability|Knee Osteoarthritis
Interventions: BEHAVIORAL: Movement Mobilization Concept, Exercise and Tape|BEHAVIORAL: Sham Movement Mobilization Concept, Exercise and Tape|BEHAVIORAL: Special Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 6 To 10
Status: TERMINATED
Conditions: Down Syndrome|Cognitive Dysfunction
Interventions: DRUG: Aricept (Donepezil hydrochloride)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hypotonia and Neurofibromatosis Type 1 (NF1) Glioma
Status: TERMINATED
Conditions: Neurofibromatosis Type 1
Interventions: DEVICE: Magnetic resonance imaging|DRUG: Gadolinium contrast
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study of a Single Dose of Meningococcal Polysaccharide Diphtheria Toxoid Conjugate Vaccine (SP284) in Japanese Subjects
Status: COMPLETED
Conditions: Meningitis|Meningococcal Meningitis|Meningococcal Infections
Interventions: BIOLOGICAL: Meningococcal polysaccharide diphtheria toxoid conjugate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Diagnostic Performance of [18F]CTT1057 in BCR
Status: COMPLETED
Conditions: Prostatic Neoplasms|Prostate Cancer|Recurrence
Interventions: DRUG: [18F]CTT1057|DRUG: [68Ga]Ga-PSMA-11
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: G-CSF PMRD: Granulocyte Colony Stimulating Factor (G-CSF) Stimulated Bone Marrow and In Vivo T-Cell Depletion in Patients With Hematologic Malignancies or Bone Marrow Failure Syndrome
Status: TERMINATED
Conditions: Hematologic Malignancies
Interventions: DRUG: Granulocyte Colony Stimulating Factor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Investigate the Safety, Pharmacodynamics and Effect on Allergic Reactivity of the Toll-like Receptor 7 (TLR7) Agonist GSK2245035 in Subjects With Respiratory Allergies
Status: COMPLETED
Conditions: Mild Asthma and Allergic Rhinitis
Interventions: DRUG: GSK2245035|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and PK Multi-dose Study of TAF/EVG Vaginal Insert
Status: RECRUITING
Conditions: Safety Issues
Interventions: DRUG: TAF/EVG vaginal insert|DRUG: Matching Placebo vaginal insert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: An Open-Label, Multicenter Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab in Combination With Tiragolumab With or Without Atezolizumab in Participants With B-Cell Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin Lymphoma, Follicular Lymphoma
Interventions: DRUG: Mosunetuzumab SC|DRUG: Tiragolumab|DRUG: Atezolizumab|OTHER: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors|Metastatic Pancreatic Cancer|Pediatric Solid Tumor|Advanced Breast Cancer|Malignant Peripheral Nerve Sheath Tumor|Colorectal Neoplasms
Interventions: DRUG: Metarrestin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allergic Rhinitis Changes the Sinus Microbiome
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: QNASL|DRUG: Placebo nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Abatacept Versus Placebo in Participants With Psoriatic Arthritis
Status: TERMINATED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Abatacept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Bioequivalence of Two Different Forms of Entrectinib (Forms A and C) Under Fasted Conditions in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Entrectinib Form A|DRUG: Entrectinib Form C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Mindfulness Practice on Coping With Primary Dysmenorrhea on Pain and Anxiety Level
Status: RECRUITING
Conditions: Dysmenorrhea|Anxiety|Anxiety Disorders and Symptoms|Pain, Menstrual
Interventions: PROCEDURE: Mindfulness training|OTHER: Will not be given any application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prolonged Ultra Low-dose Decitabine Plus Venetoclax for Primary Diagnosed Elderly AMLK/MDS
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: Decitabine for Injection|DRUG: VENCLYXTO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Explore the Therapeutic Potential of Jiedu Yizhi Formula for Alzheimer 's Disease
Status: COMPLETED
Conditions: Ensure the Legality and Compliance of the Testing Process
Interventions: DRUG: Jiedu Yizhi Formula|DRUG: Donepezil Hydrochloride Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: cKIT, BRAF/NRAS Mutations in Advanced Melanoma : Clinical Outcome in Response to Tyrosine-kinase Inhibitors - KitMel Project
Status: COMPLETED
Conditions: Melanoma
Interventions: OTHER: sequencing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Parvovirus H-1 (ParvOryx) in Patients With Metastatic Inoperable Pancreatic Cancer
Status: COMPLETED
Conditions: Carcinoma, Pancreatic Ductal
Interventions: DRUG: Parvovirus H-1 (H-1PV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanism(s) of Airflow Limitation During Exacerbation of Asthma
Status: RECRUITING
Conditions: Asthma
Interventions: DRUG: fluticasone/salmeterol in all asthmatics|DRUG: budesonide/formoterol or fluticasone/salmeterol in all asthmatics
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Efficacy and Tolerability of the Mediterranean Diet Pattern in the Exclusion Diet for Patients With Crohn's Disease.
Status: RECRUITING
Conditions: Crohn Disease
Interventions: DIETARY_SUPPLEMENT: Mediterranean Crohn's Disease Exclusion Diet (Med-CDED)|DIETARY_SUPPLEMENT: Crohn's disease exclusion diet (CDED)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Probiotics as Adjuvant Treatment for Bacterial Vaginosis
Status: COMPLETED
Conditions: Bacterial Vaginosis
Interventions: DRUG: "Probiotics" and "Metronidazole"|DRUG: Metronidazole Vaginal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cladribine With Simultaneous or Delayed Rituximab to Treat Hairy Cell Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Hairy Cell Leukemia
Interventions: DRUG: Cladribine|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DIR/ Floortime™ Parent Training Intervention for the Children With Developmental Disabilities
Status: COMPLETED
Conditions: Cerebral Palsy|Down's Syndrome|Delayed Development
Interventions: BEHAVIORAL: Parent training|BEHAVIORAL: Routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pathogen Reduction Evaluation & Predictive Analytical Rating Score
Status: COMPLETED
Conditions: Thrombocytopenia
Interventions: DEVICE: Pathogen reduced plasma-stored platelet concentrates|OTHER: Plasma-stored platelet concentrates
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Dehydroepiandrosterone (DHEA) Treatment for in Vitro Fertilization (IVF)
Status: TERMINATED
Conditions: Infertility|Decreased Ovarian Reserve
Interventions: DIETARY_SUPPLEMENT: Dehydroepiandrosterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of EMD525797 in Solid Tumor Patients in Japan
Status: COMPLETED
Conditions: Solid Tumor
Interventions: BIOLOGICAL: EMD525797|BIOLOGICAL: EMD525797|BIOLOGICAL: EMD525797|BIOLOGICAL: EMD525797
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does OCT Optimise Results of Stenting on the Left Main Stem
Status: ACTIVE_NOT_RECRUITING
Conditions: Myocardial Infarction|Myocardial Ischemia|Non ST Segment Elevation Myocardial Infarction
Interventions: DEVICE: Use of OCT to guide the angioplasty procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HVNI for Successful Weaning in Respiratory Failure
Status: RECRUITING
Conditions: Respiratory Failure|Weaning Failure
Interventions: DEVICE: High Velocity Nasal Insufflation|DEVICE: Non-invasive positive pressure ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Neoadjuvant Ipilimumab in Patients With Urothelial Carcinoma Undergoing Surgical Resection
Status: COMPLETED
Conditions: Urothelial Carcinoma
Interventions: DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cetuximab Monotherapy Maintenance Treatment in mCRC
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: Cetuximab|DRUG: mFOLFOX6|DRUG: FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualized Piano Instruction (IPI) for Improving Cognition in Breast Cancer Survivors.
Status: COMPLETED
Conditions: Breast Cancer|Chemotherapy-Related Cognitive Impairment
Interventions: BEHAVIORAL: Individualized Piano Keyboard Instruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Addition of Pembrolizumab to Postoperative Radiotherapy in Cutaneous Squamous Cell Cancer of the Head and Neck
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Pembrolizumab|RADIATION: IMRT 60-66Gy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Ultra Sound Guided Rectus Sheath Block and Field Block for Midline Hernia Repair
Status: COMPLETED
Conditions: Ultrasound Guided Rectus Sheath Block|Pain, Postoperative
Interventions: DRUG: Bupivacaine Hydrochloride 0.5% Injection Solution_#4|DRUG: Normal Saline Flush, 0.9% Injectable Solution_#5|DRUG: Bupivacaine Hydrochloride 0.5% Injection Solution_#4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 2 Trial of Anakinra for the Prevention of CAR-T Cell Mediated Neurotoxicity
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Hodgkin Lymphoma|Refractory Non-Hodgkin Lymphoma|Relapsed Non Hodgkin Lymphoma|Neurotoxicity|Neurotoxicity Syndromes|Cytokine Release Syndrome
Interventions: DRUG: Anakinra|DRUG: Axicabtagene Ciloleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest of High Flow Nasal Cannula (HFNC) Versus Non Invasive Ventilation During the Initial Management of Severe Bronchiolitis in Infants
Status: UNKNOWN
Conditions: Bronchiolitis
Interventions: DEVICE: HFNC|DEVICE: nCPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Conservative Treatment on Adolescent Idiopathic Scoliosis Patients.
Status: COMPLETED
Conditions: Adolescent Idiopathic Scoliosis
Interventions: OTHER: 3 dimensional scoliosis exercise|OTHER: Balance Exercise|OTHER: Brace treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Discontinuing NSAIDs in Veterans With Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: Meloxicam 15 mg po QD|BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Single Ascending Dose Study of the Intravitreal Plasma Kallikrein Inhibitor KVD001 in Subjects With DME
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: KVD001 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CONFORM: Rotational Fractional Resection for Submental Contouring
Status: COMPLETED
Conditions: Skin Laxity|Lipodystrophy
Interventions: DEVICE: Rotational fractional resection (1.5mm diameter device)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of COVID-19 Protein Subunit Recombinant Vaccine Adjuvanted With Alum+CpG 1018
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: SARS-CoV-2 protein subunit recombinant vaccine|BIOLOGICAL: SARS-CoV-2 inactivated vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Losartan on Cardiovascular Disease in Patients With Mucopolysaccharidoses IV A and VI
Status: ACTIVE_NOT_RECRUITING
Conditions: Mucopolysaccharidosis IV A|Mucopolysaccharidosis VI|Mucopolysaccharidoses|MPS IV A|MPS VI|MPS - Mucopolysaccharidosis|Morquio A Syndrome|Morquio Syndrome A|Morquio Syndrome
Interventions: DRUG: Losartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of a Home-based Pulmonary Telerehabilitation Program in Acute Exacerbations of COPD
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: BEHAVIORAL: Pulmonary Telerehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of GlaxoSmithKline (GSK) Biologicals' Quadrivalent Influenza Candidate Vaccine (GSK2321138A) Manufactured Using a New Process in Adults and Children
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influsplit Tetra™ vaccine produced by investigational process (IP)|BIOLOGICAL: Influsplit Tetra™ vaccine produced by licensed process (LP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Modified Psychodynamic Psychotherapy for Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: OTHER: MPP-S|OTHER: TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RCT: Early Feeding After PEG Placement
Status: RECRUITING
Conditions: Critical Illness|Malnutrition|Gastrostomy|Procedural Sequelae|Trauma|Surgery|Mechanical Ventilation
Interventions: DIETARY_SUPPLEMENT: noFast: Start tube feeds within 1 hour of procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Confounding Burden of Psychological Impairments in Cervical Spine Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Spine Disease|Psychological Impairment
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Sham Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protein Supplementation to Enhance Exercise Capacity in COPD
Status: COMPLETED
Conditions: COPD
Interventions: DIETARY_SUPPLEMENT: fortisip compact protein|DIETARY_SUPPLEMENT: preOp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy Study of Sargramostim in the Retreatment of Patients Who Have Crohn's Disease Who Have Previously Responded to Treatment With Sargramostim
Status: TERMINATED
Conditions: Crohn Disease
Interventions: DRUG: Sargramostim (Leukine)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of SAR408701 in Japanese Patients With Advanced Malignant Solid Tumors
Status: COMPLETED
Conditions: Neoplasm Malignant
Interventions: DRUG: SAR408701|DRUG: dexamethasone|DRUG: naphazoline|DRUG: diphenhydramine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Downstaging Protocol Containing Immunotherapy for HCC Beyond the Milan Criteria Before Liver Transplantation
Status: RECRUITING
Conditions: Liver Transplantation|Hepatocellular Carcinoma
Interventions: PROCEDURE: Downstaging procedures containing immunotherapy|PROCEDURE: Liver transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of 40 Hz Transcranial Stimulation on the Incidence of Emergence Delirium in Children
Status: NOT_YET_RECRUITING
Conditions: Emergence Delirium|Anesthesia|Children
Interventions: DEVICE: 40Hz stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Low Pressure Pneumoperitoneum During Laparoscopic Colorectal Surgery on Innate Immune Homeostasis.
Status: COMPLETED
Conditions: Pneumoperitoneum|Neuromuscular Blockade|Surgery|Immune Suppression
Interventions: PROCEDURE: Low pressure pneumoperitoneum|DRUG: Rocuronium bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relation Between Cervicogenic Headache and Forward Head Posture
Status: UNKNOWN
Conditions: Cervicogenic Headache
Interventions: DIAGNOSTIC_TEST: Photogrametry , flexion rotation (FRT) test, Diagnosis of CGH according diagnostic criteria of the Cervicogenic Headache International Study Group (CHISG)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: NRX-101 for Complicated Urinary Tract Infection (UTI) Including Pyelonephritis
Status: NOT_YET_RECRUITING
Conditions: Urinary Tract Infections|Pyelonephritis
Interventions: DRUG: NRX101 (a fixed dose combination of D-cycloserine (DCS) and lurasidone HCl (lurasidone))
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nimotuzumab Combined With Concurrent Chemoradiotherapy for Locally Advanced Treatment Esophageal Cancer in Old Age
Status: ENROLLING_BY_INVITATION
Conditions: Esophageal Carcinoma
Interventions: DRUG: Nimotuzumab|DRUG: Tigio|RADIATION: Concurrent radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Sympathetic Activation in Ischemia Reperfusion Injury
Status: COMPLETED
Conditions: Central Sympathetic Nervous System Diseases
Interventions: DRUG: Moxonidine 0.2 MG|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Clinical Benefit of a Transmitter for Contralateral Routing of Signals (CROS)
Status: TERMINATED
Conditions: Hearing Loss
Interventions: OTHER: BiCROS fitting|OTHER: Monaural fitting|OTHER: Unaided condition|OTHER: CROS baseline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Addition of Nab-paclitaxel (Abraxane) to First Line Treatment of Metastasized Oesophagogastric Carcinoma (ACTION)
Status: COMPLETED
Conditions: Esophageal Cancer|Toxicity
Interventions: DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dermal Safety Study to Evaluate Potential Irritation of Abametapir Lotion
Status: COMPLETED
Conditions: Head Lice
Interventions: DRUG: Abametapir Lotion 0.74% w/w|DRUG: Sodium Lauryl Sulfate|DRUG: Saline 0.9%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Digital PET Scan for the Prediction of Outcomes in Patients With Locally Advanced Oropharyngeal Cancer
Status: WITHDRAWN
Conditions: Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Locally Advanced Oropharyngeal Squamous Cell Carcinoma|Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Interventions: RADIATION: Fludeoxyglucose F-18|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rapid Acute Coronary Syndrome Exclusion Using High-sensitivity I Troponin
Status: COMPLETED
Conditions: Chest Pain|Myocardial Ischemia
Interventions: OTHER: RACE-IT Pathway|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Robotic-assisted Hysterectomy: Single- vs. Multi-port Laparoscopic Access
Status: UNKNOWN
Conditions: Activity, Motor|Pain|Wound
Interventions: PROCEDURE: Robotic single-site Hysterectomy|PROCEDURE: Laparoscopic hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of ADC189 in Children 2-11 Years Old With Influenza
Status: RECRUITING
Conditions: Influenza Type A|Influenza Type B
Interventions: DRUG: ADC189 tablets|DRUG: Baloxavir Marboxil tablets|DRUG: Placebo of ADC189 tablets|DRUG: Placebo of Baloxavir Marboxil tablets|DRUG: ADC189 granules|DRUG: Placebo of ADC189 granules|DRUG: Placebo of Oseltamivir granules|DRUG: Oseltamivir granules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Korean Society of Spine Surgery on the Outcomes of Anterior Cervical Discectomy and Fusion
Status: ACTIVE_NOT_RECRUITING
Conditions: Radiculopathy, Cervical|Myelopathy
Interventions: PROCEDURE: anterior cervical discectomy and fusion|DEVICE: Cage and Plate|DEVICE: Cage alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Characterize the PK and PD Profile of IV FCM in Pediatric Subjects 1-17 Years Old With IDA
Status: COMPLETED
Conditions: Iron Deficiency Anemia (IDA)
Interventions: DRUG: Ferric Carboxymaltose (FCM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CE-IOUS Impact on Surgical Strategy of Liver Tumours and Liver Metastases
Status: COMPLETED
Conditions: Liver Neoplasms|Liver/Hepatobiliary Cancer|Colorectal Cancer Metastatic|Metastases|Surgery|Ultrasound
Interventions: PROCEDURE: CE-IOUS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Impact on Survival of Neo-adjuvant Transarterial Chemoinfusion (TAI) for Patients With Beyond Milan Criteria BCLC Stage A/B Hepatocellular Carcinoma Who Underwent Hepatectomy
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: TAI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Effects of Passive Static Stretching of 30 Seconds Versus 60 Seconds on the Hamstring Flexibility in Adults With Hamstring Tightness.
Status: RECRUITING
Conditions: Hamstring Flexibility
Interventions: PROCEDURE: Passive Static Stretching exercises for 30 seconds|PROCEDURE: Passive Static Stretching exercises for 60 seconds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brexpiprazole (OPC 34712) Trial in the Treatment of Adults With Major Depressive Disorder and Irritability
Status: WITHDRAWN
Conditions: Major Depressive Disorder and Irritability
Interventions: DRUG: Brexpiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study for the Use of Multispectral Optoacoustic Tomography in the Detection of Tumors
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DEVICE: MSOT Device|PROCEDURE: Temperature Measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Standard vs Mini-PCNL for the Treatment of Stone Disease
Status: RECRUITING
Conditions: Urolithiasis|Kidney Stone|Kidney Calculi|Ureteral Calculi|Kidney Diseases
Interventions: PROCEDURE: PCNL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Capsaicin Patches In Knee Osteoarthritis In Obese Patients
Status: TERMINATED
Conditions: Pain
Interventions: DRUG: capsaicin 8% patches (Qutenza)|OTHER: Placebo patches
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Physiotherapist-led Exercise Within Cardiac Rehabilitation and Paroxysmal Atrial Fibrillation and COVID-19.
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation Paroxysmal
Interventions: OTHER: PT-X and IMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial Assessing the Efficacy of Lianhua Qingwen as an Adjuvant Treatment in Patients With Mild Symptoms of COVID-19
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: Lianhua Qingwen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Squalamine Lactate Ophthalmic Solution, 0.2% in Subjects With Neovascular Age-Related Macular Degeneration
Status: WITHDRAWN
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: Squalamine Lactate Ophthalmic Solution, 0.2%|DRUG: Placebo Ophthalmic Solution|DRUG: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of RenalGuard® System to Reduce the Incidence of Contrast Induced Nephropathy in At-Risk Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Contrast Induced Nephropathy
Interventions: DEVICE: RenalGuard Therapy|DRUG: Standard Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Baseline Oral Health Study: UnCoVer the Connections to General Health
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases|Diabetes Type 2
Interventions: DRUG: Subgingival chlorhexidine irrigation|OTHER: Dental Supplies|OTHER: Periodonal Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Composite Plug vs d-PTFE Membrane in Socket Preservation
Status: RECRUITING
Conditions: Alveolar Bone Loss
Interventions: PROCEDURE: Socket preservation using xenograft and composite plug|PROCEDURE: Socket preservation using xenograft and intentionally exposed d-PTFE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Gastric Emptying Speed in Patients Who Experience Diarrhea Following a Trigger Meal
Status: WITHDRAWN
Conditions: Irritable Bowel Syndrome|Diarrhea
Interventions: DRUG: pancelipase/placebo|DEVICE: SmartPill capsule|DEVICE: SmartPill capsule|DEVICE: SmartPill capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Confirm the Safety of High Frequency DRG Stimulator in Patients With Chronic Lower Limb Pain
Status: COMPLETED
Conditions: Failed Back Surgery Syndrome|Complex Regional Pain Syndrome (CRPS)
Interventions: DEVICE: GiMer Medical MN 1000 External Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing HPV Vaccine Introduction in Shanghai, China
Status: TERMINATED
Conditions: Vaccine Refusal
Interventions: BEHAVIORAL: Broadened information about cancers|BEHAVIORAL: Information about STDs|BEHAVIORAL: Information about infectious disease|BEHAVIORAL: Recommendation for children 12 years old|BEHAVIORAL: Recommendation for children 18 years old|BEHAVIORAL: Standard age information|BEHAVIORAL: Cervical cancer|BEHAVIORAL: Blank information about communicability
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bortezomib and Cisplatin as First-Line Therapy in Treating Patients With Malignant Mesothelioma
Status: COMPLETED
Conditions: Malignant Mesothelioma
Interventions: DRUG: bortezomib|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tenofovir-lamivudine-dolutegravir Combination as Second-line ART: a Randomised Controlled Trial
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Dolutegravir 50 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of CYP2B6, CYP3A4, and MDR1 in the Metabolic Clearance of Methadone
Status: UNKNOWN
Conditions: Substance-Related Disorders
Interventions: DRUG: midazolam(drug), digoxin (drug)|DRUG: Bupropion (drug)|DRUG: Methadone (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination Stem Cell (MESENDO) Therapy for Utilization and Rescue of Infarcted Myocardium
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Arteriosclerosis|Coronary Atherosclerosis|Coronary Disease
Interventions: BIOLOGICAL: MESENDO|BIOLOGICAL: MESENDO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pomalidomide, Cyclophosphamide and Prednisone (PCP) in Patients With Multiple Myeloma (MM) Relapsed and/or Refractory to Lenalidomide
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Pomalidomide, Cyclophosphamide, Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Specific Micronutrient-probiotic-supplement on Fatty Liver of Patients After Mini-Gastric Bypass Surgery
Status: COMPLETED
Conditions: Obesity|Gastric Bypass|NAFLD
Interventions: DIETARY_SUPPLEMENT: Micronutrient-probiotic-combination|DIETARY_SUPPLEMENT: Micronutrient-placebo-combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Ultrasound-guided Nerve Block for Painful Hand Injuries in the Emergency Department
Status: COMPLETED
Conditions: Hand Injuries|Hand Injuries and Disorders
Interventions: PROCEDURE: Ultrasound-guided forearm nerve block|DRUG: 1:1 volume measured solution of: 1% lidocaine without epinephrine and 0.5% bupivacaine without epinephrine|DEVICE: Bedside ultrasound machine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT