pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Prospective Clinical Trial Comparing Infraclavicular Versus Axillary Approach to Brachial Plexus Block
Status: UNKNOWN
Conditions: Scaphoid Fractures|Distal Radius Fractures|Wrist Injury Arthrodesis
Interventions: DEVICE: Ultrasound: Axillary block|DEVICE: Ultrasound: Infraclavicular block|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraocular Pressure in Children With Acute Lymphoblastic Leukemia (ALL) Treated With High Dose Steroids
Status: UNKNOWN
Conditions: ALL, Childhood|Steroid-Induced Glaucoma
Interventions: DEVICE: Intraocular pressure measurment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Post-operative Methylprednisolone Taper Course for Orthopedic Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Orthopedic Surgeries
Interventions: DRUG: 10 mg IV dexamethasone & 6 day oral methylprednisolone taper|OTHER: 10 mg IV dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aldosterone and the Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Diseases|Diabetes Mellitus|Endocrine System Diseases|Glucose Metabolism Disorders
Interventions: DRUG: Hydrochlorothiazide (HCTZ)|DRUG: Aliskiren 150 mg (ALI 150)|DRUG: Spironolactone (SPL 25)|DRUG: Aliskiren 300 mg (ALI 300)|DRUG: Spironolactone 50 mg (SPL 50)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Insulin Detemir Versus Neutral Protamine Hagedorn (NPH) Insulin in Pregnant Women With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin detemir|DRUG: NPH insulin|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapy-Optimization Trial for the Treatment of Acute Myeloid Leukemias (AML) in Children and Adolescents
Status: UNKNOWN
Conditions: Myeloid Leukemia
Interventions: DRUG: Anthracyclines|DRUG: liposomal daunorubicin|DRUG: 2-CDA|DRUG: AI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Changing the Dosing Regimen on the PK Profile of ODM-203
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ODM-203 (Period 1)|DRUG: ODM-203 (Period 2)|DRUG: ODM-203 (Periods 3-6)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Tdap Vaccine in Post-Partum Women
Status: COMPLETED
Conditions: Diphtheria|Pertussis|Tetanus
Interventions: BIOLOGICAL: Tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine adsorbed onto aluminum phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: PREVENTION
Clinical trial: A Telehealth Advance Care Planning Intervention in Those With Mild Cognitive Impairment or Unrecognized Dementia
Status: COMPLETED
Conditions: Advance Care Planning|Telemedicine|Mild Cognitive Impairment|Unrecognized Dementia|Dementia
Interventions: BEHAVIORAL: Telehealth visit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Abemaciclib With or Without Atezolizumab in Metastatic Castration Resistant Prostate Cancer
Status: WITHDRAWN
Conditions: Prostate Cancer
Interventions: DRUG: Abemaciclib 200 MG|DRUG: Atezolizumab 1200 MG in 20 ML Injection|DRUG: Abemaciclib 150 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of Golimumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Colitis, Ulcerative
Interventions: DRUG: Golimumab|DRUG: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple-Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ONO-2952 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ONO-2952|DRUG: ONO-2952 Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TC-5214 as add-on the Treatment of Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder|Depression
Interventions: DRUG: TC-5214 + citalopram|DRUG: Placebo + citalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Using Navigational Bronchoscopy to Perform PDT-Photofrin® in Unresectable Peripheral Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer (NSCLC)|Lung Metastasis
Interventions: DRUG: Porfimer sodium|DEVICE: Fiber optic
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Anti-inflammatory Effect of Anesthetics in Abdominal Surgery
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: OTHER: Lidocaine|OTHER: Ketamine|OTHER: Lidocaine and Ketamine|OTHER: Placebo (0.9% NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effect and Safety of Polyethylene Glycol Combined With Linaclotide on Colon Cleansing for Patients With Chronic Constipation
Status: UNKNOWN
Conditions: Bowel Preparation
Interventions: DRUG: Linaclotide|DRUG: Compound Polyethylene Glycol Electrolyte Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Safety, Tolerability and Efficacy Assessment of Dynacirc CR in Parkinson Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Isradipine CR 5mg|DRUG: Isradipine CR 10mg|DRUG: Isradipine CR 20mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BAY59-7939 in Atrial Fibrillation Once Daily (OD)
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Xarelto (Rivaroxaban, BAY59-7939)|DRUG: Xarelto (Rivaroxaban, BAY59-7939)|DRUG: Xarelto (Rivaroxaban, BAY59-7939)|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety Study to Test the Safety of HspE7 and Poly-ICLC Given in Patients With Cervical Intraepithelial Neoplasia
Status: UNKNOWN
Conditions: Cervical Intraepithelial Neoplasia
Interventions: BIOLOGICAL: HspE7 and Poly-ICLC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: The Analysis of Heart Rate Variability With 24hrs Holter ECG and Serum Cardiac Fibrosis Markers in Critical Illness Patients Who Are With Cardiogenic Shock, With ECMO or IABP Support, or With APACH II Score >25)
Status: COMPLETED
Conditions: Cardiogenic Shock,|With ECMO or IABP Support,|With APACH II Score >25)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The PrISICE Clinical Trial (Pre-Implantation Screening and Investigation on the Cryopreservation of Embryos)
Status: TERMINATED
Conditions: Infertility
Interventions: PROCEDURE: Trophectoderm biopsy|PROCEDURE: Cryopreservation|PROCEDURE: Embryo Transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Two Oral Nitisinone Formulations to Treat Hereditary Tyrosinemia (HT-1)
Status: COMPLETED
Conditions: Hereditary Tyrosinemia, Type I
Interventions: DRUG: Nitisinone|DRUG: Nitisinone Baked Tablet|DRUG: Orfadin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate the Safety and Efficacy of Dermal Injections of JVS-100 Given to Adults Receiving Median Sternotomy
Status: UNKNOWN
Conditions: Median Sternotomy
Interventions: BIOLOGICAL: JVS-100 or placebo|BIOLOGICAL: JVS-100 or placebo|BIOLOGICAL: JVS-100 or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ASP1948, Targeting an Immune Modulatory Receptor as a Single Agent and in Combination With a PD-l Inhibitor (Nivolumab or Pembrolizumab) in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: ASP1948|DRUG: nivolumab|DRUG: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Response of Mirtazapine to Methamphetamine Induced Interest, Mood Elevation and Reward
Status: WITHDRAWN
Conditions: Amphetamine Dependence
Interventions: DRUG: Mirtazapine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing the Clinical Efficacy and Health Outcomes of Outpatients With Mild to Moderate Community-Acquired Pneumonia (CAP) Treated With Either Telithromycin Once Daily for 7 Days, or Azithromycin Once Daily for 5 Days
Status: TERMINATED
Conditions: Pneumonia
Interventions: DRUG: telithromycin|DRUG: azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of Drospirenone-ethinylestradiol and/or NOMAC-valerate Estradiol on Cardiovascular Risk in Women With Polycystic Ovary Syndrome
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Zoely|DRUG: Yasmin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Tolerability of Intravenous CRS-207 in Adults With Selected Advanced Solid Tumors Who Have Failed or Who Are Not Candidates for Standard Treatment
Status: TERMINATED
Conditions: Malignant Epithelial Mesothelioma|Adenocarcinoma of the Pancreas|Carcinoma, Non-Small-Cell Lung|Adenocarcinoma of the Ovaries
Interventions: BIOLOGICAL: CRS-207, Live-attenuated Listeria monocytogenes expressing human Mesothelin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Savolitinib for Treating Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) Patients
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer Metastatic
Interventions: DRUG: Savolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Value of Supervised Exercise Therapy After Invasive Treatment of Peripheral Arterial Disease
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: PROCEDURE: angioplasty / surgery|PROCEDURE: Angioplasty / surgery and exercise therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Extension Study Evaluating the Efficacy and Safety of Rivastigmine in Patients With Traumatic Brain Injury (TBI) With Persistent Cognitive Deficits
Status: COMPLETED
Conditions: Traumatic Brain Injury With Persistent Cognitive Deficits
Interventions: DRUG: Rivastigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Comparison Between Low Pressure Pneumoperitoneum With High Pressure Pneumoperitoneum in Post-operative Pain, Shoulder Tip Pain and Common Bile Duct Injuries in Patients Undergoing Laparoscopic Cholecystectomy
Status: RECRUITING
Conditions: Cholecystectomy|Pneumoperitoneum|Pain, Postoperative
Interventions: DEVICE: Changing pressure of Pneumoperitoneum to 6-10 mmHg|DEVICE: Changing pressure of Pneumoperitoneum to 12-15 mmHg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Extracorporeal Shockwave Therapy in the Treatment for Erectile Dysfunction in Male Renal Transplant Recipients
Status: COMPLETED
Conditions: Erectile Dysfunction|Renal Transplant
Interventions: PROCEDURE: Extracorporeal shockwave therapy|PROCEDURE: Extracorporeal shockwave therapy - sham treatment|OTHER: Penile ultrasound Doppler with intracavernosal injection application 20 mcg alprostadil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Treatments for Convergence Insufficiency
Status: COMPLETED
Conditions: Convergence Insufficiency
Interventions: PROCEDURE: Pencil Push-ups|PROCEDURE: Office-based Vision Therapy|PROCEDURE: Placebo Office-based Vision Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Golimumab Trough Levels in Patients With Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DIAGNOSTIC_TEST: Golimumab trough levels|DIAGNOSTIC_TEST: Antibodies to golimumab|DIAGNOSTIC_TEST: Histology|DIAGNOSTIC_TEST: Colonoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trifluridine/Tipiracil and Irinotecan for the Treatment of Advanced Refractory Biliary Tract Cancer
Status: COMPLETED
Conditions: Advanced Bile Duct Carcinoma|Advanced Gallbladder Carcinoma|Refractory Bile Duct Carcinoma|Refractory Gallbladder Carcinoma|Stage III Distal Bile Duct Cancer AJCC v8|Stage III Gallbladder Cancer AJCC v8|Stage III Intrahepatic Bile Duct Cancer AJCC v8|Stage IIIA Distal Bile Duct Cancer AJCC v8|Stage IIIA Gallbladder Cancer AJCC v8|Stage IIIA Intrahepatic Bile Duct Cancer AJCC v8|Stage IIIB Distal Bile Duct Cancer AJCC v8|Stage IIIB Gallbladder Cancer AJCC v8|Stage IIIB Intrahepatic Bile Duct Cancer AJCC v8|Stage IV Distal Bile Duct Cancer AJCC v8|Stage IV Gallbladder Cancer AJCC v8|Stage IV Intrahepatic Bile Duct Cancer AJCC v8|Stage IVA Gallbladder Cancer AJCC v8|Stage IVB Gallbladder Cancer AJCC v8
Interventions: DRUG: Irinotecan|DRUG: Irinotecan Hydrochloride|DRUG: Trifluridine and Tipiracil Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two Schedules of Hyperfractionated Thoracic Radiotherapy in Limited Disease Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Small Cell Lung Carcinoma
Interventions: RADIATION: 45 Gy in 30 fractions|RADIATION: 60 Gy in 40 fractions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MEDI5083 Alone and in Combination With Durvalumab, Tremelimumab, and/or Docetaxel.
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: BIOLOGICAL: MEDI5083 monotherapy|BIOLOGICAL: MEID5083 with Durvalumab or Tremelimumab|BIOLOGICAL: Medi5083 with Durvalumab and Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prenatal Surgical Repair of Fetal Myelomeningocele
Status: COMPLETED
Conditions: Foetus With Myelomeningocele
Interventions: PROCEDURE: prenatal surgical repair of fetal myelomeningocele
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy of Erlotinib for Leptomeningeal Carcinomatosis in EGFR Mutation Positive Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Leptomeningeal Carcinomatosis|Non-small Cell Lung Cancer
Interventions: DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Zinc and / or Micronutrient Supplementation on Intestinal Flora, Diarrheal Disease Burden, Intestinal Mucosal Integrity and Growth Among Children of Pakistan
Status: COMPLETED
Conditions: Malnutrition|Diarrhea|Pneumonia|Growth
Interventions: DIETARY_SUPPLEMENT: Micronutrient Supplementation without Zinc|DIETARY_SUPPLEMENT: Micronutrient Supplementation with Zinc|OTHER: Nutritional Counselling and Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Early Immunoglobulin A Nephropathy by Angiotensin Converting Enzyme Inhibitor - A Randomized Controlled Trial
Status: COMPLETED
Conditions: Biopsy-confirmed IgA Nephropathy|Proteinuria Less Than 0.5 g Per Day|Normal Blood Pressure|Serum Creatinine Below 120 Umol/l
Interventions: DRUG: Ramipril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ropeginterferon Alfa 2b for Early MyelofibrosisDIPSS Low/Intermediate-1 Risk Myelofibrosis
Status: RECRUITING
Conditions: Pre-fibrotic Myelofibrosis
Interventions: DRUG: Ropeginterferon Alfa-2B Prefilled Syringe [Besremi]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Hyperoxaluria and Kidney Stones
Status: COMPLETED
Conditions: Secondary Hyperoxaluria|Nephrolithiasis|Kidney Stones|Hyperoxaluria|Dietary Hyperoxaluria
Interventions: DRUG: ALLN-177 low dose|DRUG: ALLN-177 mid dose|DRUG: ALLN-177 high dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aspirin in Patients With Myocardial Infarction and Thrombocytopenia
Status: TERMINATED
Conditions: Thrombocytopenia|Myocardial Infarction
Interventions: DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Fibrinogen-Depleted Human Platelet Lysate in Patients With Dry Eye Secondary to Graft vs. Host Disease
Status: COMPLETED
Conditions: Dry Eye|Graft-versus-host-disease|Ocular Discomfort
Interventions: BIOLOGICAL: CAM-101 10%|BIOLOGICAL: Vehicle Control|BIOLOGICAL: CAM-101 30%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Resveratrol Supplementation on Exercise in Healthy Sedentary Adults
Status: COMPLETED
Conditions: Sedentary Lifestyle
Interventions: DRUG: Resveratrol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Mometasone Furoate Nasal Spray in Perennial Allergic Rhinitis (Study P03748)(COMPLETED)
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial
Interventions: DRUG: Placebo|DRUG: Mometasone furoate|DRUG: Mometasone furoate|DRUG: Mometasone furoate|DRUG: Mometasone furoate|DRUG: Mometasone furoate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exploratory Clinical Study to Investigate the Ability of an Experimental Combination Dentifrice to Protect Sensitive Teeth
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: OTHER: 3% PVM/MA + 5% KNO3 Combination|OTHER: 3% PVM/MA only|OTHER: 5% KNO3 Only|OTHER: Regular Fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Contribution of Fast-ripples to the Improvement of the Neurosurgical Management of Drug-refractory Epilepsy
Status: RECRUITING
Conditions: Epilepsy
Interventions: DEVICE: DIXI Medical Microdeep® Micro- Macro Depth electrodes|DEVICE: Standard electrodes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Blood Pressure Control Achieved in Antihypertensive or Generic Drugs in Moderate to Severe Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: period with drug (trade name) then period with generic|DRUG: period with generic then period with drug (trade name)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Analysing the Effects of Xingnaojing for Mild-to-severe Acute Ischemic Stroke
Status: UNKNOWN
Conditions: Acute Stroke|Ischemic Stroke
Interventions: DRUG: Xingnaojing injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Predictors of Recovery and the App-Facilitated Tele-Rehabilitation (AFTER) Program for COVID-19 Survivors
Status: COMPLETED
Conditions: Covid-19|Deconditioning
Interventions: BEHAVIORAL: Biobehavioral Tele-rehabilitation Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of [18F] PM-PBB3 PET Imaging of Tau Protein in Neurodegenerative Diseases
Status: RECRUITING
Conditions: Neurodegenerative Diseases
Interventions: DIAGNOSTIC_TEST: 18F-PBB3 PET/CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Influence of Prostaglandins on Ocular Blood Flow in Glaucoma Patients
Status: COMPLETED
Conditions: Open-Angle Glaucoma
Interventions: DRUG: travoprost 0.004% (drug)|DRUG: latanoprost 0.005% (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Translational Study of Single Agent Olaparib in the Treatment of Advanced Oesophagogastric Cancer
Status: UNKNOWN
Conditions: Oesophageal Cancer|Gastro-Oesophageal Junction Cancer|Gastric Cancer
Interventions: DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methadone Anesthesia For Kidney Transplant Receptors
Status: UNKNOWN
Conditions: Renal Failure Chronic|Surgery
Interventions: DRUG: Methadone|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Comparison of Topical Application of Alvogyl Versus Hyaluronic-Acid Gel in Management of Pain And Palatal Wound Healing
Status: UNKNOWN
Conditions: Wound Healing
Interventions: OTHER: Alvogyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Magnesium Supplementation in Type II Diabetes
Status: COMPLETED
Conditions: Effect of Magnesium in Diabetes
Interventions: DIETARY_SUPPLEMENT: Magnesium citrate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Melphalan, Prednisone, and CC-5013 (Revlimid) as Induction Therapy in Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Revlimid (CC-5013)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carbetocin at Elective Cesarean Deliveries: A Dose-finding Study in Women With BMI ≥ 40kg/m2
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Carbetocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Subfoveal Choroidal Thickness and Visual Acuity After Intravitreal Injection of Ranibizumab in Diabetic Retinopathy
Status: COMPLETED
Conditions: Subfoveal Choroidal Thickness|Intravitreal|Ranibizumab|Visual Acuity|Diabetic Retinopathy
Interventions: PROCEDURE: Intravitreal injection of ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Injected Ranibizumab to Treat Macular Telangiectasia Without New Blood Vessel Formation
Status: COMPLETED
Conditions: Telangiectasia
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First-in-human Study of the Safety, Pharmacokinetics, Pharmacodynamics and Anti-tumor Activity of SAR439459 Monotherapy and Combination of SAR439459 and Cemiplimab in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Malignant Solid Tumor
Interventions: BIOLOGICAL: SAR439459|DRUG: Cemiplimab REGN2810
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial of Intranasal Injection of Platelet-Rich Plasma for Treatment of Parosmia
Status: NOT_YET_RECRUITING
Conditions: Paraosmia
Interventions: OTHER: Platelet-rich Plasma (PRP)|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Blocking Mifepristone Action With Progesterone
Status: TERMINATED
Conditions: Pregnancy, Unwanted
Interventions: DRUG: Mifepristone 200 MG|DRUG: micronized Progesterone|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Placebo Controlled Evaluation of the Cell Mediated Immune Response of Cirrhotic Subjects to Zostavax™
Status: COMPLETED
Conditions: Herpes Zoster|Fibrosis
Interventions: BIOLOGICAL: Zostavax|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Compare the Blood Levels of Mim8 in Healthy Men When Administered With the DV3407-C1 Pen Injector or a Syringe and Cartridge
Status: COMPLETED
Conditions: Haemophilia A
Interventions: DRUG: NNC0365-3769 (Mim8)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Long-Term Safety Study of S5G4T-1 in the Treatment of Papulopustular Rosacea
Status: TERMINATED
Conditions: Papulopustular Rosacea
Interventions: DRUG: S5G4T-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin Versus Vildagliptin in Reducing Risk of Metabolic Syndrome Complications Progression
Status: UNKNOWN
Conditions: Metabolic Syndrome|Diabete Type 2|Kidney Insufficiency
Interventions: DRUG: Vildagliptin|DRUG: Captopril Tablets|DRUG: MetFORMIN 500 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Danish ICD Study in Patients With Dilated Cardiomyopathy
Status: COMPLETED
Conditions: Heart Failure|Dilated Cardiomyopathy|Reduced LVEF
Interventions: DEVICE: ICD|OTHER: Optimal medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Efficacy and Safety of Ornithine Aspartic Acid Granules in NAFLD Against Silymarin Capsules
Status: UNKNOWN
Conditions: Non-alcoholic Fatty Liver Disease
Interventions: DRUG: Ornithine aspartate granule|DRUG: Silymarin capsule|DRUG: Silymarin capsule simulant|DRUG: Ornithine aspartate granule simulant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial to Assess the Impact of a Screening Program on Upper Aerodigestive Tract Cancer Mortality in a High Risk Population
Status: COMPLETED
Conditions: Pharynx Cancer|Larynx Cancer|Oral Cavity Cancer|Oesophageal Cancer
Interventions: PROCEDURE: Screening by head and neck clinical examination with a fiberoptic nasolaryngoscopy and an oesopharyngeal brush biopsy annually during 3 years
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 12 Versus 20 mL PCB for D&E Cervical Prep
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: 12 mL paracervical block|DRUG: 20 mL paracervical block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Development of a Molecular Diagnostic Strategy for SARS-CoV2 Based on Saliva in the Context of the COVID-19 Pandemic
Status: COMPLETED
Conditions: COVID|RT-ddPCR Multiplex
Interventions: DIAGNOSTIC_TEST: Saliva collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Biomarkers for Circadian Timing in Healthy Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Sleep Wake Disorders|Sleep Disorders, Circadian Rhythm|Sleep Disorders, Intrinsic|Advanced Sleep Phase Syndrome (ASPS)|Advanced Sleep Phase Syndrome|Advanced Sleep Phase|Delayed Sleep Phase|Delayed Sleep Phase Syndrome|Non-24 Hour Sleep-Wake Disorder|Irregular Sleep-Wake Syndrome|Shift-Work Sleep Disorder|Shift Work Type Circadian Rhythm Sleep Disorder|Delayed Phase Sleep Syndrome
Interventions: BEHAVIORAL: sleep-wake timing|BEHAVIORAL: constant routine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Developmental Care Program in Neonatal Intensive Care Unit
Status: ENROLLING_BY_INVITATION
Conditions: Premature Birth
Interventions: BEHAVIORAL: Family Education and Active Listening|BEHAVIORAL: Family Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Genetically Engineered Cells (MAGE-A1-specific T Cell Receptor-transduced Autologous T-cells) and Atezolizumab for the Treatment of Metastatic Triple Negative Breast Cancer, Urothelial Cancer, or Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Lung Non-Small Cell Carcinoma|Metastatic Malignant Solid Neoplasm|Metastatic Triple-Negative Breast Carcinoma|Metastatic Urothelial Carcinoma|Stage IV Lung Cancer AJCC v8
Interventions: DRUG: Atezolizumab|DRUG: Cyclophosphamide|DRUG: Fludarabine|BIOLOGICAL: MAGE-A1-specific T Cell Receptor-transduced Autologous T-cells|BIOLOGICAL: PD1 Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of High-calcium Intake on Substrate Metabolism During Exercise
Status: COMPLETED
Conditions: Lipid Metabolism
Interventions: DIETARY_SUPPLEMENT: Calcium|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Loop-tipped Guidewire in Selective Biliary Cannulation
Status: COMPLETED
Conditions: Choledocholithiasis|Bile Duct Cancer|Pancreatic Cancer|Ampullary Tumor
Interventions: DEVICE: Biliary cannulation with loop guidewire|DEVICE: Biliary cannulation with straight guidewire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18 Week Study Evaluating Safety and Efficacy of Olmesartan, Amlodipine, and Hydrochlorothiazide, in Type 2 Diabetics
Status: COMPLETED
Conditions: Type 2 Diabetes|Hypertension
Interventions: DRUG: Amlodipine|DRUG: amlodipine / olmesartan medoxomil combination|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare the Effectiveness and Safety of Genoss® DCB and IN.PACT Admiral® DCB in Patients With Peripheral Artery Disease
Status: COMPLETED
Conditions: Peripheral Artery Disease|De Novo Stenosis
Interventions: DEVICE: Genoss® DCB|DEVICE: IN.PACT Admiral® DCB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone vs Ondansetron After Cesarean Delivery
Status: COMPLETED
Conditions: Nausea and Vomiting, Postoperative|Cesarean Section Complications
Interventions: DRUG: Ondansetron|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phlebotomy and Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Hyperandrogenism|Metabolic Cardiovascular Syndrome
Interventions: PROCEDURE: Phlebotomy|DRUG: ethinylestradiol|DRUG: Cyproterone Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Inhaled Cannabis For the Uncontrolled Pain Relief in Patients With Advanced Cancer
Status: UNKNOWN
Conditions: Cancer Pain|Quality of Life|Pain, Acute|Cannabis Use
Interventions: DRUG: PPP001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics After High Single Ascending Oral Doses of AZD1656 in T2DM Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: AZD1656|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lifestyle Behavioural Intervention on Breast Cancer Survivors for the Treatment of Overweight/Obesity.
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer Female|Overweight and Obesity
Interventions: BEHAVIORAL: Behavioural Lifestyle (BL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Clinical Tolerability of hdmASIT+TM Peptides Administered in HDM-induced Allergic Patients
Status: COMPLETED
Conditions: House Dust Mite Allergy
Interventions: BIOLOGICAL: Placebo solution|BIOLOGICAL: hdmASIT+TM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effect of Zoledronic Acid Versus Denosumab on Serum Sclerostin of Postmenopausal Women With Low Bone Mass
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis
Interventions: DRUG: Denosumab|DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Effects of Chronic Administration of Spironolactone and/or Propranolol in Alcoholic Cirrhotic Patients
Status: TERMINATED
Conditions: Alcoholic Cirrhosis
Interventions: DRUG: Propranolol - Spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Safety and Dose Ranging Study of Acellular Pertussis and Acellular Pertussis -Tetanus-Diphtheria Booster Vaccines in Healthy Adults Ages 18 to 40 Years
Status: COMPLETED
Conditions: Pertussis|Whooping Cough|Tetanus|Lockjaw|Diphtheria
Interventions: BIOLOGICAL: Acellular pertussis vaccine|BIOLOGICAL: Tetanus, reduced diphtheria, and acellular pertussis vaccine (adsorbed)|BIOLOGICAL: Licensed TdaP booster vaccine|BIOLOGICAL: Diphtheria and tetanus vaccine (adsorbed, reduced antigen content, Germany)|OTHER: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Monosodium L-Glutamate (MSG) and Nucleic Acid (IMP) on Satiety and Food Intake
Status: COMPLETED
Conditions: Nutrition Intervention
Interventions: DIETARY_SUPPLEMENT: Soup 1|DIETARY_SUPPLEMENT: Soup 2|DIETARY_SUPPLEMENT: Soup 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate Long-term Outcomes Following Treatment With ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 With or Without Ribavirin (RBV) in Adults With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection
Status: COMPLETED
Conditions: Chronic Hepatitis C Virus (HCV) Infection Genotype 1
Interventions: DRUG: ABT-450/r/ABT-267|DRUG: ABT-333|DRUG: Ribavirin (RBV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-intensity Intervals Versus Low-to-moderate-intensity Exercise Training in Patients With PAD
Status: RECRUITING
Conditions: Peripheral Arterial Disease
Interventions: OTHER: High-intensity interval training group (HIIT)|OTHER: Low-to-moderate intensity training group (LowMod group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telbivudine Versus Adefovir Dipivoxil in Adults With HBegAg-Positive, Compensated Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: Telbivudine (LdT)|DRUG: Adefovir Dipivoxil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of AL2846 Capsule Combined With TQB2450 Injection Compared to Docetaxel Injection in Advanced Non-small Cell Lung Cancer Patients Who Have Failed With Immunotherapy.
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: TQB2450 injection, docetaxel injection matching placebo, AL2846 capsules|DRUG: TQB2450 matching placebo, docetaxel injection, AL2846 matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin Type A (Botox) for the Treatment of Cervical Dystonia and Upper Thoracic Muscular Pain
Status: COMPLETED
Conditions: Refractory Cervicothoracic Myofascial Pain Syndrome (CMPS)|Cervical Dystonia
Interventions: DRUG: Botulinum Toxin Type A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Primary and Booster Vaccination Study With Pneumococcal Vaccine GSK1024850A in Healthy Japanese Children
Status: COMPLETED
Conditions: Infections, Streptococcal
Interventions: BIOLOGICAL: Pneumococcal vaccine GSK1024850A|BIOLOGICAL: DTPa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: HEPA, PM2.5, and Cardiometabolic Health
Status: RECRUITING
Conditions: Air Pollution|Cardiometabolic Health
Interventions: DEVICE: HEPA filter|DEVICE: Sham filter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: TACE and SBRT Followed by Double Immunotherapy for Downstaging Hepatocellular Carcinoma
Status: RECRUITING
Conditions: HCC
Interventions: PROCEDURE: TACE|RADIATION: SBRT|DRUG: Durvalumab|DRUG: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ScopeGuide-assisted Colonoscopy Versus Conventional Colonoscopy
Status: COMPLETED
Conditions: Colonic Neoplasms|Iron Deficiency Anemia|Diarrhea
Interventions: DEVICE: Olympus ScopeGuide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 3 Study in Participants With Moderate to Severe Psoriasis (UNCOVER-2)
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: 80 mg ixekizumab Dosing Regimen|DRUG: 50 mg etanercept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Intravenous and Oral Steroids for Multiple Sclerosis Attacks
Status: TERMINATED
Conditions: Multiple Sclerosis
Interventions: DRUG: megadose oral methylprednisolone|DRUG: IV methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on the Efficacy of Single-port Inflatable Mediastinoscopy Combined With Laparoscopic-assisted Small Incision Surgery and Thoracoscopy Combined With Laparoscopic Surgery for Radical Esophagectomy
Status: NOT_YET_RECRUITING
Conditions: Esophageal Cancer
Interventions: PROCEDURE: Single-Port Inflatable Mediastinoscopy Combined With Laparoscopic-Assisted Small Incision Surgery|PROCEDURE: Thoracoscopy Combined With Laparoscopic Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Adoptive Treatment of Advanced Hepatocellular Carcinoma With Allogeneic γδ-T Cells
Status: WITHDRAWN
Conditions: Advanced Hepatocellular Carcinoma
Interventions: BIOLOGICAL: GDKM-100 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Communication of Genetic Test Results By Telephone: A Multi-Center Study
Status: COMPLETED
Conditions: Candidates for BRCA 1/2 Genetic Testing
Interventions: GENETIC: Genetic Providers|OTHER: Visual Aids|OTHER: Post-Disclosure Asessments|OTHER: In-person Clinical Follow-Up|OTHER: 6 Month and 12 Month Assessments
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Investigate Efficacy and Safety of a Single Injection of Org 36286 for Ovarian Stimulation Using Daily Recombinant FSH as Reference (Ensure)(P05690/MK-8962-001)
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: corifollitropin alfa (Org 36286)|DRUG: recFSH (follitropin beta)|DRUG: gonadatropin releasing hormone (GnRH) antagonist (ganirelix)|DRUG: human chorion gonadatropin (hCG)|BIOLOGICAL: progesterone|DRUG: placebo-recFSH (follitropin alfa)|DRUG: placebo-corifollitropin alfa|BIOLOGICAL: open-label recFSH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Antisepsis Regimen in the Surgical Treatment of Human Papilloma Virus Generated Cervical Lesions: Polyhexamethylene Biguanide Versus Chlorhexidine
Status: COMPLETED
Conditions: Antisepsis Regimen After Surgical Treatment of HPV Infected Lesions
Interventions: DEVICE: Chlorhexidine vaginal suppositories|DEVICE: Polyhexamethylene biguanide vaginal suppositories
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Assessing the Impact of DAy Programs on Individuals Living With Dementia and Their Family/Friend Caregivers
Status: NOT_YET_RECRUITING
Conditions: Adult Day Programs|Continuing Care|Old Age; Dementia|Family/Friend Caregivers
Interventions: OTHER: Adult day program use|OTHER: Other community care (non-attendees)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: RUPP PI PDD: Drug and Behavioral Therapy for Children With Pervasive Developmental Disorders
Status: COMPLETED
Conditions: Child Development Disorders, Pervasive
Interventions: DRUG: Risperidone|BEHAVIORAL: Behavior Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Increasing Access to Smoking Cessation and Smoke Free Home Services for Low-Income Pregnant Women in Northeast Texas
Status: RECRUITING
Conditions: Cigarette Smoking-Related Carcinoma
Interventions: OTHER: Informational Intervention|OTHER: Informational Intervention|OTHER: Informational Intervention|OTHER: Media Intervention|OTHER: Questionnaire Administration|BEHAVIORAL: Smoking Cessation Intervention|OTHER: Survey Administration|BEHAVIORAL: Telephone-Based Intervention|BEHAVIORAL: Telephone-Based Intervention|OTHER: Tobacco Cessation Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH