pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of the Safety, Tolerability and Pharmacokinetics of TMB-607 in HIV-Negative Volunteers
Status: TERMINATED
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: TMB-607|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Clinical Study of FOLFOXIRI With Bevacizumab As First-line Therapy in Patients With mCRC
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: BIOLOGICAL: Bevacizumab|DRUG: 5-fluorouracil|DRUG: Irinotecan hydrochloride|DRUG: Leucovorin calcium|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Repeatability and Reproducibility of OCTA Image Quality With the Heidelberg Engineering SPECTRALIS With OCT Angiography Module
Status: TERMINATED
Conditions: Retinal Vascular|Normal Eyes
Interventions: DEVICE: OCT Angiography|DEVICE: Color Fundus Photography|DEVICE: Optical Coherence Tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Prophylactic Arterial Embolization in the Treatment of Angiography-negative Acute Upper Gastrointestinal Bleeding
Status: UNKNOWN
Conditions: Acute Gastrointestinal Bleeding
Interventions: PROCEDURE: embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Piloting an Online Integrated Behaviour Change and Physical Activity Program
Status: UNKNOWN
Conditions: Neurological Disorder|Behavioural Change Intervention|Physical Activity
Interventions: BEHAVIORAL: Integrated Physical Activity and Behavioural Change Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Feasibility Study of a Multi-Component Intervention for Black Men Who Have Sex With Men
Status: COMPLETED
Conditions: HIV Infections
Interventions: BEHAVIORAL: Referral of Partners|BEHAVIORAL: Screening for STIs and counseling|BEHAVIORAL: Peer health care system navigators|BEHAVIORAL: Enhanced counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Citicoline as Neuroprotector in Neonates Exposed to Hypoxia
Status: RECRUITING
Conditions: Neonatal Hypoxia
Interventions: DRUG: Citicoline|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors
Status: TERMINATED
Conditions: Anaplastic Astrocytoma|Anaplastic Ependymoma|Astrocytoma, Grade II|Ependymoma|Giant Cell Glioblastoma|Glioblastoma|Gliosarcoma|Oligodendroglioma|Brainstem Tumors
Interventions: DRUG: imetelstat sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in America
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: DRUG: Semaglutide|DRUG: Orlistat|DRUG: Phentermine/Topiramate|DRUG: Naltrexone/Bupropion|DRUG: Liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety and Efficacy of a Once-daily Dose of Tigecycline vs Ertapenem in Diabetic Foot Infections (DFI) With a Substudy in Patients With Diabetic Foot Infections Complicated by Osteomyelitis.
Status: COMPLETED
Conditions: Bacterial Infections|Diabetic Foot|Osteomyelitis
Interventions: DRUG: Tigecycline|DRUG: Ertapenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sacroiliac Joint Fusion Versus Sham Operation for Treatment of Sacroiliac Joint Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Sacroiliac Joint Somatic Dysfunction
Interventions: PROCEDURE: iFuse|PROCEDURE: sham group|RADIATION: fMRI study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Hydrochloride With or Without Erlotinib Hydrochloride Followed by the Same Chemotherapy Regimen With or Without Radiation Therapy and Capecitabine or Fluorouracil in Treating Patients With Pancreatic Cancer That Has Been Removed by Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Adenocarcinoma|Pancreatic Ductal Adenocarcinoma|Pancreatic Intraductal Papillary-Mucinous Neoplasm|Stage I Pancreatic Cancer AJCC v6 and v7|Stage II Pancreatic Cancer AJCC v6 and v7
Interventions: RADIATION: 3-Dimensional Conformal Radiation Therapy|PROCEDURE: Biospecimen Collection|DRUG: Capecitabine|DRUG: Chemotherapy|PROCEDURE: Computed Tomography|DRUG: Erlotinib Hydrochloride|DRUG: Fluorouracil|DRUG: Gemcitabine Hydrochloride|RADIATION: Intensity-Modulated Radiation Therapy|PROCEDURE: Magnetic Resonance Imaging|OTHER: Quality-of-Life Assessment|PROCEDURE: X-Ray Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intravenous Dexamethasone With Pudendal Nerve Block on Postoperative Pain in Pediatric Hypospadias Repair
Status: COMPLETED
Conditions: Postoperative Pain|Hypospadias
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Bleeding Profile With Continuous Hormone Replacement Therapy of Activelle® in Postmenopausal Women
Status: COMPLETED
Conditions: Menopause|Healthy
Interventions: DRUG: 1.0 mg estradiol / 0.5 mg norethisterone acetate (NETA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bilateral Subthalamic Stimulation in PD Patients With Impulse Control Disorders - STIMPulseControl
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease|Impulse Control Disorders
Interventions: PROCEDURE: bilateral high frequency deep brainstimulation of the subthalamic nucleus combined with best medical treatment|DRUG: best medical treatment (BMT): Adjustment of the dopaminergic medication and non-dopaminergic therapy customized for each patient according to the latest published Consensus Group Recommendations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Efficacy of Tranexamic Acid in the Treatment of Lichen Planus Pigmentosus and Erythema Dyschromicum Perstans
Status: RECRUITING
Conditions: Lichen Planus Pigmentosus|Erythema Dyschromicum Perstans|Ashy Dermatosis of Ramirez
Interventions: DRUG: Tranexamic acid tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dynamic Difficulty Adjustment in a P300 Speller Task for Attention Training
Status: COMPLETED
Conditions: Attention
Interventions: OTHER: Task difficulty adaptation according to Arvaneh et al. (2019)|OTHER: Random task difficulty|OTHER: Task difficulty adaptation according to iterative learning controller
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Immunogenicity and Safety of GSK Biologicals' Boostrix Polio Vaccine in 3 and 4-year-old Children
Status: COMPLETED
Conditions: Acellular Pertussis|Poliomyelitis|Tetanus|Diphtheria
Interventions: BIOLOGICAL: Boostrix PolioTM|BIOLOGICAL: RepevaxTM|BIOLOGICAL: PriorixTM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: HPV Vaccination in Africa- New Delivery Schedules Alias The HANDS HPV Vaccine Trial
Status: UNKNOWN
Conditions: Human Papillomavirus Vaccine
Interventions: BIOLOGICAL: 9-valent human papillomavirus vaccine (Gardasil 9) - 3 doses|BIOLOGICAL: 9-valent human papillomavirus vaccine (Gardasil 9) - 2 doses|BIOLOGICAL: 9-valent human papillomavirus vaccine (Gardasil 9) - 1 dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Rising Oral Doses of BI 201335 as Softgel Capsule in Naive Hepatitis C Virus (HCV) Patients
Status: COMPLETED
Conditions: Hepatitis C|Pharmacokinetics
Interventions: DRUG: ribavirin (RBV)|DRUG: pegylated interferon (PegIFN) alfa-2a|DRUG: pegylated interferon (PegIFN) alfa-2a|DRUG: ribavirin (RBV)|DRUG: BI 201335 NA low placebo|DRUG: pegylated interferon (PegIFN) alfa-2a|DRUG: ribavirin (RBV)|DRUG: BI 201335 NA high|DRUG: BI 201335 NA low|DRUG: BI 201335 NA high placebo|DRUG: BI 201335 NA high|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Pre-Treatment Vestibular Physical Therapy Rehab for Patients With Vestibular Schwannomas
Status: RECRUITING
Conditions: Vestibular Schwannoma
Interventions: PROCEDURE: Microsurgical resection of VS|RADIATION: Stereotactic radiosurgery|OTHER: PREHAB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial Testing Amiodarone in Chagas Cardiomiopathy
Status: UNKNOWN
Conditions: Chagas Cardiomyopathy
Interventions: DRUG: Amiodarone Hydrochloride|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DP-b99 in the Treatment of Acute High-risk Pancreatitis
Status: TERMINATED
Conditions: Pancreatitis
Interventions: DRUG: DP-b99|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial on the Articular Pain of Diagnosed Patients of Arthrosis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DIETARY_SUPPLEMENT: nutraceutical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of GFS101A in Combination With Toripalimab in Patients With Advanced Solid Tumors
Status: WITHDRAWN
Conditions: Solid Tumor
Interventions: DRUG: GFS101A|DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bile Acids and Incretins in Pancreas Kidney Transplant Patients
Status: COMPLETED
Conditions: Pancreas-kidney Transplantation|Kidney Transplantation
Interventions: PROCEDURE: pancreas kidney transplantation|PROCEDURE: kidney transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: An Epidemiological Study to Investigate the Characteristics of RSV Infection in Adult Hematopoietic Cell Transplant Recipients or Hematological Malignancies Patients in Tianjin HI (Hematology Institute)
Status: RECRUITING
Conditions: RSV Infection
Interventions: OTHER: RSV infection observation cohort
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Peripartum Cardiomyopathy in Nigeria Registry
Status: COMPLETED
Conditions: Peripartum Cardiomyopathy
Interventions: DRUG: Oral Sodium Selenite 200 µg/day for 3 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FSH and LH Versus FSH Alone for Ovarian Stimulation in Non-hormone Sensitive Onco-fertility Patients
Status: NOT_YET_RECRUITING
Conditions: Fertility Preservation
Interventions: DRUG: Luveris
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mesalamine for Colorectal Cancer Prevention Program in Lynch Syndrome
Status: RECRUITING
Conditions: Lynch Syndrome|Colon Cancer|Colon Neoplasm
Interventions: DRUG: Mesalamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Mechanism of rTMS on the Symptoms of Pleasure Deficit in Adolescent Depression
Status: NOT_YET_RECRUITING
Conditions: Depression
Interventions: DEVICE: Repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid Mechanisms and Pharmacokinetics in Traumatic Injury
Status: COMPLETED
Conditions: Hemorrhage|Shock|Wounds and Injuries
Interventions: DRUG: Tranexamic Acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of Intravenous Immunoglobulin in Patients With Chronic Immune Thrombocytopenic Purpura (ITP)
Status: COMPLETED
Conditions: Immune Thrombocytopenic Purpura
Interventions: BIOLOGICAL: IgPro10
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AR-12286 in Combination With Latanoprost
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: Latanoprost 0.005%|DRUG: AR-12286 Ophthalmic Solution 0.5%|DRUG: Timolol maleate ophthalmic solution 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AI in PRImary Care Spirometry Pathways for Diagnosis of Lung Disease (APRIL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Diseases
Interventions: OTHER: Spirometry decision support software (ArtiQ.Spiro)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Coadministration of Ume Paste (Prunus Mume) and Ginger Powder
Status: COMPLETED
Conditions: Prediabetes
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Ume paste and ginger powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Rotation-traction Manipulation of Different Treatment Frequency in Cervical Radiculopathy
Status: NOT_YET_RECRUITING
Conditions: Cervical Radiculopathy
Interventions: OTHER: High-frequency rotation-traction manipulation|OTHER: Low-frequency rotation-traction manipulation|OTHER: Cervical traction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Face-to-face vs Online Physical Exercise in Seniors Living in Nursing Homes (ExerMOT-NH)
Status: RECRUITING
Conditions: Physical Function|Cognitive Decline|Psychological Well-Being
Interventions: BEHAVIORAL: Advice to increase physical activity and reduce sedentary behavior|BEHAVIORAL: Online Physical Exercise|BEHAVIORAL: Face-to-Face Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Does Terlipressin Improve Renal Outcome After Liver Surgery
Status: WITHDRAWN
Conditions: Kidney Failure
Interventions: DRUG: Terlipressin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Open Randomized Study of Comparative Pharmacokinetics and Biosimilarity of GP40221 (GEROPHARM LLC, Russia) and Ozempic®.
Status: COMPLETED
Conditions: Pharmacokinetics|Safety Issues|Bioequivalence
Interventions: DRUG: GP40221|DRUG: ozempic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The PK Study of the JLP-1207 and Solifenacin/Tamsulosin in Healthy Male Volunteers.
Status: COMPLETED
Conditions: LUTS(Lower Urinary Tract Symptoms)|Benign Prostatic Hyperplasia|Overactive Bladder
Interventions: DRUG: JLP-1207|DRUG: Solifenacin 5mg+Tamsulosin 0.2mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Osteomyelitis-associated Pressure Ulcers by Surgical Flaps and Anti-bacterial Agents
Status: RECRUITING
Conditions: Disability or Chronic Disease Leading to Disablement|Pressure Ulcer|Osteomyelitis
Interventions: OTHER: Surgical flap and anti-bacterial agents
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Participants With Dialysis-dependent Chronic Kidney Disease (DD-CKD)
Status: COMPLETED
Conditions: Anemia|Dialysis-Dependent Chronic Kidney Disease
Interventions: DRUG: Vadadustat|DRUG: Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Randomized Trial Comparing Stereotactic Body Radiation Therapy (SBRT) vs Conventional Palliative Radiation Therapy for Painful Bone Metastases
Status: RECRUITING
Conditions: Bone Metastases
Interventions: DRUG: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-modal Neuroimaging in Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: BEHAVIORAL: Memory assessment|BIOLOGICAL: Circulating biomarkers measure|GENETIC: ApoE4|OTHER: Brain imaging examination MRI and PET examinations
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Adaptation and Pilot Implementation of ePNa Clinical Decision Support for Utah Urgent Care Clinics
Status: RECRUITING
Conditions: Pneumonia
Interventions: OTHER: Physician Survey|DEVICE: ePNa-CheXED
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy Study of Oral Arginine to Improve Immune Function in Glioblastoma Multiforme
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: arginine in powder form|DRUG: Silica and cellulose placebo powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of 16 Weeks of Duration to Evaluate Retreatment With Elbasvir/Grazoprevir Plus Sofosbuvir and Ribavirin in Patients With Chronic Hepatitis C Genotypes 1,4 Who Have Failed to Treat With a Regime Based on an Inhibitor of the NS5A
Status: WITHDRAWN
Conditions: HCV
Interventions: DRUG: elbasvir/grazoprevir|DRUG: Sofosbuvir|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proton Radiation for Unresectable, Borderline Resectable, or Medically Inoperable Carcinoma of the Pancreas
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: RADIATION: Proton Radiation|DRUG: Capecitabine|PROCEDURE: Surgical resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of EB-203 Eye Drops in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: EB-203|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Triamcinolone Acetonide for Treatment of Refractory Diffuse Diabetic Macular Edema
Status: UNKNOWN
Conditions: Diabetic Retinopathy
Interventions: DRUG: triamcinolone acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Azithromycin on Failure Proportion of Severe Periodontitis Non-surgical Treatment
Status: TERMINATED
Conditions: Severe Chronic Periodontitis
Interventions: DRUG: Non-surgical periodontal treatment and azithromycin treatment|OTHER: Non-surgical periodontal treatment and placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chronic Heart Failure - COngestion eValuation
Status: RECRUITING
Conditions: Chronic Heart Failure
Interventions: PROCEDURE: Clinical examination centered on congestion|PROCEDURE: Cardiac, pulmonary, peritoneal, jugular, renal Doppler ultrasounds and liver elastography|PROCEDURE: Blood sample retrieved for biological assessment and biobanking|OTHER: Telephone follow-up|BEHAVIORAL: Kansas City Cardiomyopathy Questionnaire (KCCQ)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Robot-Assisted Partial Knee Replacement Versus Standard Total Knee Replacement
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Total knee arthroplasty|PROCEDURE: Robot-assisted partial knee arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Different Exercise Modes on Bile Acid Levels and Liver Function in Patients With Non-alcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease NAFLD
Interventions: BEHAVIORAL: Aerobic training (AT)|BEHAVIORAL: Resistance training (RT)|BEHAVIORAL: Combined aerobic and resistance training (AT + RT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nitro Oxide Inhalation Continued With Sildenafil on Neonatal Persistent Pulmonary Hypertension
Status: UNKNOWN
Conditions: Persistent Pulmonary Hypertension of Newborn
Interventions: DRUG: NO inhalation|DRUG: NO inhalation continued with sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab With Carboplatin/Paclitaxel in Patients With Metastatic Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Malignant Melanoma
Interventions: DRUG: Pembrolizumab|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics Study of Linzagolix in Female Subjects With Normal and Impaired Hepatic Function
Status: COMPLETED
Conditions: Hepatic Impairment|Healthy Participants
Interventions: DRUG: Linzagolix
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neovascularization Embolisation for Knee Osteoarthritis.(NEO)
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: Embolization|PROCEDURE: Sham embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Soticlestat With Itraconazole and Mefenamic Acid in Healthy Adults
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Soticlestat|DRUG: Itraconazole|DRUG: Mefenamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safe and Efficacious Iron for Children in Kenya
Status: COMPLETED
Conditions: Anaemia
Interventions: DIETARY_SUPPLEMENT: Low-dose iron as NaFeEDTA|DIETARY_SUPPLEMENT: Conventional dose iron as ferrous salt|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose-Ranging Study to Evaluate Efficacy and Safety of Weekly CJC-1134-PC in Patients With T2DM on Metformin Monotherapy
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus (T2DM)
Interventions: DRUG: CJC-1134-PC Injection|DRUG: Weekly placebo for CJC-1134-PC Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thoracic Radiotherapy Plus Maintenance Durvalumab After First Line Carboplatin and Etoposide Plus Durvalumab in Extensive-stage Disease Small Cell Lung Cancer (ED-SCLC).
Status: ACTIVE_NOT_RECRUITING
Conditions: Small Cell Lung Cancer|Lung Cancer
Interventions: DRUG: Durvalumab|DRUG: carboplatin|DRUG: etoposide|RADIATION: Thoracic radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Escalating Doses of Polatuzumab Vedotin in Participants With Relapsed or Refractory B-Cell Non-Hodgkins Lymphoma and Chronic Lymphocytic Leukemia and Polatuzumab Vedotin in Combination With Rituximab in Participants With Relapsed or Refractory B-Cell Non-Hodgkins Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkins Lymphoma|Chronic Lymphocytic Leukemia
Interventions: DRUG: Polatuzumab Vedotin|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of Oprozomib Administered Orally in Patients With Advanced Refractory or Recurrent Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Oprozomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Handoffs and Transitions in Critical Care - Understanding Scalability
Status: ENROLLING_BY_INVITATION
Conditions: Patient Handoff|Healthcare Team|Communication|Patient Safety|Intensive Care Units
Interventions: BEHAVIORAL: Customized handoff
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia
Status: RECRUITING
Conditions: Hypotension Drug-Induced
Interventions: DRUG: Ephedrine-P|DRUG: Phenylephrine-P|DRUG: Norepinephrine-P|DRUG: Ephedrine-S|DRUG: Phenylephrine-S|DRUG: Norepinephrine-S
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of One-Step Sentinel Lymph Node (SLN) Biopsy With Radiolabeled Methylene Blue (IND 70,627)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Methylene blue
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Benzodiazepine Study for the Treatment of Seizure Clusters in a Third Level Mexican Neurological Center
Status: RECRUITING
Conditions: Cluster Seizure
Interventions: DRUG: Midazolam oral solution|DRUG: ClonazePAM Oral Product|OTHER: Usual medication/ traditional
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Intranasal Application of GX-03 as a Treatment and Prevention for COVID-19.
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: GX-03|DRUG: Petrolatum ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Cefdinir and Cephalexin for the Treatment of Mild to Moderate Uncomplicated Skin Infections
Status: COMPLETED
Conditions: Mild to Moderate Uncomplicated Skin and Skin Structure Infections
Interventions: DRUG: cefdinir|DRUG: cephalexin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Sodium Valproate and Valproic Acid Tablets
Status: ACTIVE_NOT_RECRUITING
Conditions: Epilepsy
Interventions: DRUG: Sodium valproate and valproic acid extended release tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Monitor-Guided Analgesia During General Anesthesia - Part II
Status: COMPLETED
Conditions: Pain, Postoperative|Pain|Nociceptive Pain|Opioid Use|Analgesia
Interventions: PROCEDURE: Opioid administration (remifentanil) in intervention group|PROCEDURE: Opioid administration (remifentanil) in control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Robotic-assisted Esophagectomy vs. Video-Assisted Thoracoscopic Esophagectomy(REVATE) Trial
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DEVICE: Robot esophagectomy (RE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaginal Probiotics and Pessaries and Their Impact on the Vaginal Microenvironment
Status: COMPLETED
Conditions: Pelvic Organ Prolapse|Inflammatory Response|Dysbiosis
Interventions: OTHER: BiopHreshTM vaginal probiotic supplement (Good Clean Love, Inc. Eugene, OR) and RestoreTM gel.|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Zinc Absorption From Zinc Biofortified Rice in Bangladeshi Children
Status: UNKNOWN
Conditions: Malnourished Children
Interventions: DIETARY_SUPPLEMENT: Diet-ZnBfR: Zinc biofortified rice-based diet|DIETARY_SUPPLEMENT: Diet- CR: Conventional rice-based diet|DIETARY_SUPPLEMENT: CR + Zn: Conventional rice-based diet plus zinc fortificant (Diet-CR+Z).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Study - ES 900 - 2020-2
Status: COMPLETED
Conditions: Cataract|Keratoconus
Interventions: DEVICE: Haag-Streit EYESTAR 900|DEVICE: Tomey CASIA 2|DEVICE: Oculus PENTACAM HR|DEVICE: Zeiss ATLAS 9000
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: HuMax-CD20 in B-Cell Chronic Lymphocytic Leukemia (B-CLL) Patients Failing Fludarabine and Alemtuzumab
Status: COMPLETED
Conditions: Leukaemia, Lymphocytic, Chronic
Interventions: DRUG: ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tracking Early Emergence of Sound Perception Impairments in FXS With Multimodal fNIRS/EEG-Preschool Age
Status: RECRUITING
Conditions: Fragile X Syndrome
Interventions: OTHER: Speech discrimination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of House Dust Mite Allergen Extract in the Treatment of Allergic Rhinoconjunctivitis
Status: COMPLETED
Conditions: House Dust Mite Allergy
Interventions: BIOLOGICAL: House dust mite Novo Helisen Depot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Alimta in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma (NPC) Who Have Had Prior Platinum Based Chemotherapy
Status: COMPLETED
Conditions: Nasopharyngeal Neoplasms
Interventions: DRUG: Pemetrexed (Alimta)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Repetitive Transcranial Magnetic Stimulation (PrTMS)
Status: RECRUITING
Conditions: Neck Pain
Interventions: DEVICE: Personalized Repetitive Transcranial Magnetic Stimulation|DEVICE: Sham Personalized Repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Magnesium Sulfate in Children Undergoing Laparoscopic Appendectomy
Status: NOT_YET_RECRUITING
Conditions: Opioid Consumption|Multimodal Analgesia|Acute Appendicitis|Complication of Treatment
Interventions: DRUG: Intravenous magnesium sulfate|DRUG: Normal saline infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Influences of Gingival Cord Retractor in Retention Rate of Non-carious Cervical Lesions Restorations.
Status: UNKNOWN
Conditions: Dental Wear|Tooth Wear
Interventions: PROCEDURE: Gingival displacement|PROCEDURE: Enamel and dentin etched|PROCEDURE: Selective enamel etched|PROCEDURE: Wash and dry|DEVICE: Total-etch adhesive system|DEVICE: self-conditioning adhesive system|PROCEDURE: Photoactivated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intralesional HPV Vaccine for Condylomata
Status: RECRUITING
Conditions: Human Papilloma Virus|Warts|Warts, Genital|Condyloma|Condylomata Acuminata
Interventions: BIOLOGICAL: nonavalent human papillomavirus vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser in Caries Treatment - Patients´View, Pulpal Reactions and Survival of Fillings
Status: COMPLETED
Conditions: Dental Caries
Interventions: DEVICE: excavated with rotary bur|DEVICE: Er:YAG laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bortezomib With Melphalan and Prednisone for Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib|DRUG: Melphalan|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BreCLIM-2 - A RCT Investigating Local Treatment for Breast Cancer Liver Metastases
Status: RECRUITING
Conditions: Breast Cancer|Liver Metastases
Interventions: PROCEDURE: Surgical intervention|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Proficiency-based Versus Free Laparoscopic Training in Cholecystectomy on a Virtual Reality Simulator
Status: UNKNOWN
Conditions: Cholelithiasis|Cholecystitis|Cholecystolithiasis
Interventions: PROCEDURE: Laparsocopic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Comparative Multicenter Randomized Study of Aflibercept Versus Placebo in Macular Telangiectasia Type 1
Status: RECRUITING
Conditions: Macular Telangiectasia
Interventions: OTHER: Inclusion examinations|DRUG: Aflibercept Injection [Eylea]|DRUG: SHAM injection|OTHER: Examinations during study (every month)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: D-chiro-Inositol in Overweight Type 1 Diabetes Patients
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DIETARY_SUPPLEMENT: D-chiro-inositol|DIETARY_SUPPLEMENT: Folic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Echocardiography Predictive of the Inefficacy and/or of the Unsafeness of Recruitment Maneuvers in Patients With Acute Respiratory Distress Syndrome.
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome
Interventions: DEVICE: Echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Longevity, Functional Status and Quality of Life of the Compress® Compliant Pre-Stress System
Status: TERMINATED
Conditions: Compress Compliant Pre-Stress System|Malignant Bone Tumor
Interventions: DEVICE: Compress Compliant Pre-Stress System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Dual Trigger for Final Oocyte Maturation on IVF/ICSI Outcomes in Patients With Suboptimal Ovarian Response
Status: COMPLETED
Conditions: Ovarian Stimulation|Reproductive Techniques, Assisted
Interventions: OTHER: Dual triggering
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Main Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients
Status: COMPLETED
Conditions: Opioid Dependence|Methadone Withdrawal Syndrome
Interventions: DRUG: Lofexidine HCl|DRUG: Lofexidine-matching sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Blocking Blue Light at Night Post CABG, AVR, MVR, CABG AVR, CABG MVR, or SAH
Status: RECRUITING
Conditions: Circadian Rhythm Disorders
Interventions: OTHER: Blue light-blocking goggles|OTHER: Clear goggles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of the Teleconsultation of Renal Nutrition on Renal Function and Glycemic Control in Patients With DKD
Status: COMPLETED
Conditions: Diet Modification|Diabetic Kidney Disease|Chronic Kidney Diseases
Interventions: BEHAVIORAL: Renal nutrition teleconsultation|BEHAVIORAL: Face-to-face consultation of renal nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telephone-Based Educational Intervention in Improving Communication Between Patients With Stage 0-III Cancer and Their Children
Status: COMPLETED
Conditions: Breast Cancer|Cervical Cancer|Colon Cancer|Leukemia|Lymphoma|Malignant Neoplasm|Melanoma|Rectal Cancer
Interventions: OTHER: educational intervention|BEHAVIORAL: telephone-based intervention|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: E-lombactifs: Evaluation of the Impact a Smartphone Application on Adherence an Exercise Program in Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: OTHER: Education in the use of smartphone app (Mon coach dos)|OTHER: conventional care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT
Status: COMPLETED
Conditions: Vitamin D Deficiency|Stem Cell Transplant Complications|Pediatric Cancer|Blood Disorder|Pediatric Acute Myeloid Leukemia|Pediatric Acute Lymphoid Leukemia|Myelodysplastic Syndromes|Sickle Cell Anemia in Children|Aplastic Anemia|Thalassemia in Children
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Standard Vitamin D3 Supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optical Coherence Tomography Angiography (OCTA) in Children's Cardiac Surgery
Status: NOT_YET_RECRUITING
Conditions: Congenital Heart Disease|Children, Only
Interventions: DIAGNOSTIC_TEST: OCTA measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety Study of PCI-32765 Combine With Ofatumumab in CLL
Status: COMPLETED
Conditions: B-cell Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|Prolymphocyctic Leukemia|Richter's Transformation
Interventions: DRUG: PCI-32765|DRUG: ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Ergoferon for COVID-19 Prevention During Vaccination Against SARS-CoV-2
Status: COMPLETED
Conditions: Immunization Against COVID-19
Interventions: DRUG: Ergoferon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of a Dietary Supplementation Combining Proteins and Pomegranate Extracts in Older People
Status: COMPLETED
Conditions: Healthy Aging
Interventions: DIETARY_SUPPLEMENT: Dietary Supplement|OTHER: Placebo of the dietary supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinical Performance of Adhesive Systems Containing HEMA and 10-MDP in Non Carious Cervical Lesions
Status: COMPLETED
Conditions: Non Carious Cervical Lesion
Interventions: OTHER: composite resin restoration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Zinc Carnosine on Intestinal Permeability in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Zinc Carnosine coadministered with Indomethacin|OTHER: Placebo coadministered with Indomethacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Cardiac Rehabilitation Peer Mentorship
Status: COMPLETED
Conditions: Percutaneous Coronary Intervention|Coronary Artery Bypass Graft Surgery, With or Without Valve Surgery|Acute Coronary Syndrome|Chronic Stable Heart Failure|Coronary Artery Disease
Interventions: BEHAVIORAL: Cardiac Rehabilitation Peer Mentorship
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study Using Human Papillomavirus (HPV) DNA Testing to Detect HPV-Related Oropharyngeal Cancer (OPC)
Status: RECRUITING
Conditions: Oropharyngeal Cancer|HPV-Related Carcinoma|HPV Positive Oropharyngeal Squamous Cell Carcinoma
Interventions: DIAGNOSTIC_TEST: NavDx
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: NY-ESO-1 Plasmid DNA (pPJV7611) Cancer Vaccine
Status: COMPLETED
Conditions: Prostate Cancer|Bladder Cancer|Non-small Cell Lung Cancer|Esophageal Cancer|Sarcoma
Interventions: BIOLOGICAL: NY-ESO-1 Plasmid DNA Cancer Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of AK104 (PD-1/CTLA-4 Bispecial Antibody) Combined With Chemotherapy for Neoadjuvant Treatment of Advanced Ovarian Cancer
Status: NOT_YET_RECRUITING
Conditions: Advanced Ovarian Cancer|AK104(PD-1/CTLA-4 Bispecial Antibody)|Chemotherapy|Efficacy|Safety
Interventions: DRUG: AK104
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cannabidiol for Bipolar Depression (CBD-BD)
Status: RECRUITING
Conditions: Bipolar Disorder
Interventions: DRUG: Cannabidiol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The HIV Testing Using Enhanced Screening Techniques in Emergency Departments Trial
Status: COMPLETED
Conditions: Rapid HIV Screening
Interventions: OTHER: A: Nontargeted rapid HIV screening|OTHER: B: Enhanced targeted rapid HIV screening|OTHER: C: Traditional targeted rapid HIV screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Web-based Training to Educate Physicians in the Methods of Interpreting Florbetapir-PET Scans
Status: COMPLETED
Conditions: Alzheimer Disease|Mild Cognitive Impairment|Neurodegenerative Diseases
Interventions: DRUG: florbetapir F 18
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: ATTUNE® Revision- Complex Primary in Total Knee Arthroplasty Population
Status: RECRUITING
Conditions: Primary Knee Arthroplasty
Interventions: DEVICE: ATTUNE Revision Knee System in Total Knee Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT