pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Two Intrathecal Doses of Autologous Mesenchymal Stem Cells for Amyotrophic Lateral Sclerosis
Status: UNKNOWN
Conditions: AMYOTROPHIC LATERAL SCLEROSIS
Interventions: OTHER: Two intrathecal MSC injections
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib Tosylate in Treating Patients With Desmoid Tumors or Aggressive Fibromatosis
Status: COMPLETED
Conditions: Desmoid Fibromatosis
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Placebo Administration|OTHER: Quality-of-Life Assessment|DRUG: Sorafenib Tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Low-risk Fever and Neutropenia in Children With Cancer: Safety and Efficacy of Oral Antibiotics in an Outpatient Setting
Status: TERMINATED
Conditions: Fever|Neutropenia|Cancer
Interventions: DRUG: ciprofloxacin and amoxicillin|PROCEDURE: Outpatient management|DRUG: i.v. antibiotics|PROCEDURE: inpatient management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online Mindfulness for Women Treated for Breast Cancer and Men Treated for Prostate Cancer
Status: COMPLETED
Conditions: Anxiety Depression|Breast Cancer Female|Prostate Cancer
Interventions: BEHAVIORAL: Internet-delivered Mindfulness-Based Cognitive Therapy|BEHAVIORAL: Waitlist control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influenza HA Ferritin Vaccine, Alone or in Prime-Boost Regimens With an Influenza DNA Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: VRC-FLUNPF081-00-VP (HA-F A/Sing)|BIOLOGICAL: VRC-FLUDNA082-00-VP (DNA A/Sing)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Magnesium as a Mediator of Bone and Vitamin D Metabolism in Patients on Antiepileptic Drug Therapy
Status: TERMINATED
Conditions: Epilepsy|Magnesium Deficiency|Vitamin D Deficiency
Interventions: OTHER: No Intervention. Study is Cross Sectional in nature
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Acetaminophen IV vs Hydromorphone IV in the ED
Status: COMPLETED
Conditions: Pain, Acute
Interventions: DRUG: Acetaminophen|DRUG: Hydromorphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Calypso-based Deep Inspiration Breath Hold (DIBH) Radiation Treatments of Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: DEVICE: Calypso Beacon Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Blocks or Not in Joint Arthroplasty
Status: RECRUITING
Conditions: Osteoarthritis of the Knee or Hip
Interventions: DRUG: Ropivacain 5 mg/ml + Clonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First Research Study of the Possible New Medicine NNC0113-2023 in Healthy Men.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: NNC0113-2023|DRUG: Placebo (NNC0113-2023)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electrical Vestibular Nerve Stimulation (VeNS) as a Treatment for Insomnia
Status: COMPLETED
Conditions: Insomnia|Sleep Disturbance
Interventions: DEVICE: VeNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BioMime Vs. Xience Randomised Control Clinical Study
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: Sirolimus Eluting Coronary Stent|DEVICE: Everolimus-eluting Coronary stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Metformin With Gefitinib to Treat NSCLC
Status: COMPLETED
Conditions: NSCLC|EGFR Gene Amplification|Advanced Cancer|Stage IIIB NSCLC|Stage IV NSCLC
Interventions: DRUG: Gefitinib and Metformin|DRUG: Gefitinib and placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CASH (Cavernous Angiomas With Symptomatic Hemorrhage) Trial Readiness
Status: COMPLETED
Conditions: CCM|Cavernoma|Cerebral Cavernous Malformation|Cerebral Cavernous Malformations 1|Cerebral Cavernous Malformations 2|Cerebral Cavernous Malformations 3|Cavernous Angioma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of 0.4% Hyaluronic Acid Solution Versus Hydroxyethylamide Solution in Submucosal Endoscopic Resections
Status: RECRUITING
Conditions: Esophageal Neoplasms|Endoscopic Mucosal Resection|Hyaluronic Acid
Interventions: PROCEDURE: Submucous Endoscopic Dissection with hydroxyethylamide|PROCEDURE: Submucous Endoscopic Dissection with Hyaluronic acid (TS-905 Blue Eye)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect Mechanism Investigation of a Non-invasive Stimulation Device for Rapid Alleviation of Parkinson's Disease Symptoms
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DEVICE: Electrical Stimulation|OTHER: Dry Needling Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Management of Superficial Thrombophlebitis
Status: COMPLETED
Conditions: Superficial Thrombophlebitis|Upper Extremity Superficial Thrombophlebitis|Lower Extremity Superficial Thrombophlebitis
Interventions: DRUG: Dalteparin sodium injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and XL888 in Patients With Advanced Gastrointestinal Cancer
Status: COMPLETED
Conditions: Colorectal Adenocarcinoma|Metastatic Pancreatic Adenocarcinoma|Recurrent Colorectal Carcinoma|Recurrent Pancreatic Carcinoma|Stage III Colorectal Cancer|Stage III Pancreatic Cancer|Stage IIIA Colorectal Cancer|Stage IIIB Colorectal Cancer|Stage IV Colorectal Cancer|Stage IV Pancreatic Cancer|Stage IVA Colorectal Cancer|Stage IVA Pancreatic Cancer|Stage IVB Colorectal Cancer|Stage IVB Pancreatic Cancer|Unresectable Pancreatic Carcinoma
Interventions: DRUG: XL888|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Mass Balance, Pharmacokinetics (PK), and Metabolism of Orally Administered [14 C]-TAK-659 in Participants With Advanced Solid Tumor and/or Lymphoma Malignancies
Status: WITHDRAWN
Conditions: Advanced Solid Neoplasms|Lymphoma Neoplasms
Interventions: DRUG: [14C]-TAK-659|DRUG: TAK-659
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Gentuximab Combined With Paclitaxel Compared With Placebo Combined With Paclitaxel for Gastric Adenocarcinoma.
Status: RECRUITING
Conditions: Adenocarcinoma of Stomach
Interventions: DRUG: Gentuximab Injection|DRUG: Gentuximab Injection Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colchicine for Amyotrophic Lateral Sclerosis
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Colchicine 1 MG Oral Tablet|DRUG: Colchicine 1 MG Oral Tablet|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Pharmacodynamics Study of BCD-066 Compared to Aranesp® in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Transcutaneous Electrical Nerve Stimulation (TENS)-Assisted Weight Loss
Status: TERMINATED
Conditions: Overweight|Obesity
Interventions: DEVICE: Transcutaneous Nerve Stimulator (TENS)|BEHAVIORAL: Diet & Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MELA Study - Hedonic Study on the Taste of Drugs Crushed in Food: Observational Study Involving 16 Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Jelly with:Paracetamol|OTHER: Jelly with Furosemide|OTHER: Jelly with Levothyroxine sodium salt|OTHER: Jelly with Memantine|OTHER: Jelly with Zopiclone|OTHER: Jelly with Alprazolam|OTHER: Jelly with Oxazepam|OTHER: Jelly with Donepezil|OTHER: Jelly with Clopidogrel|OTHER: Jelly with Ramipril|OTHER: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam|OTHER: Plain jelly control|OTHER: Apple compote Paracetamol|OTHER: Apple compote Furosemide|OTHER: Apple compote Levothyroxine sodium salt|OTHER: Apple compote Memantine|OTHER: Apple compote Zopiclone|OTHER: Apple compote Alprazolam|OTHER: Apple compote Oxazepam|OTHER: Apple compote Donepezil|OTHER: Apple compote Clopidogrel|OTHER: Apple compote Ramipril|OTHER: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam|OTHER: Plain apple compote control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Monoclonal Antibody Therapy and Peripheral Stem Cell Transplant in Treating Patients With Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Contiguous Stage II Adult Diffuse Large Cell Lymphoma|Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma|Contiguous Stage II Grade 1 Follicular Lymphoma|Contiguous Stage II Grade 2 Follicular Lymphoma|Contiguous Stage II Grade 3 Follicular Lymphoma|Contiguous Stage II Mantle Cell Lymphoma|Contiguous Stage II Marginal Zone Lymphoma|Contiguous Stage II Small Lymphocytic Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma|Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma|Noncontiguous Stage II Grade 1 Follicular Lymphoma|Noncontiguous Stage II Grade 2 Follicular Lymphoma|Noncontiguous Stage II Grade 3 Follicular Lymphoma|Noncontiguous Stage II Mantle Cell Lymphoma|Noncontiguous Stage II Marginal Zone Lymphoma|Noncontiguous Stage II Small Lymphocytic Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Stage I Adult Diffuse Large Cell Lymphoma|Stage I Adult Diffuse Small Cleaved Cell Lymphoma|Stage I Grade 1 Follicular Lymphoma|Stage I Grade 2 Follicular Lymphoma|Stage I Grade 3 Follicular Lymphoma|Stage I Mantle Cell Lymphoma|Stage I Marginal Zone Lymphoma|Stage I Small Lymphocytic Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Small Lymphocytic Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Small Lymphocytic Lymphoma|Waldenström Macroglobulinemia
Interventions: BIOLOGICAL: rituximab|DRUG: cyclophosphamide|BIOLOGICAL: filgrastim|RADIATION: yttrium Y 90 ibritumomab tiuxetan|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutraceutical Support of Fatigue Reduction, Improved Physical, Mental & Cognitive Function and Mitochondrial Function
Status: COMPLETED
Conditions: Fatigue
Interventions: DIETARY_SUPPLEMENT: ATP-Fuel|DIETARY_SUPPLEMENT: ATP-II|DIETARY_SUPPLEMENT: ATP-II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Prospective Cohort of Obinutuzumab and Chlorambucil (GC) Chemotherapy for the Treatment of Elderly Patients With Chronic Lymphocytic Leukemia Including Next- Generation Sequencing (NGS)-Based Assessment
Status: UNKNOWN
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of eHealth Encouragements to Intensive Exercise in Adolescents With Congenital Heart Disease
Status: COMPLETED
Conditions: Congenital Heart Disease
Interventions: BEHAVIORAL: Lifestyle counseling|BEHAVIORAL: eHealth intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study for Adult Patients With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia, Primary|Fibromyalgia, Secondary
Interventions: DRUG: Duloxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Thalidomide Combined With Low-dose Hormones in the Treatment of Severe COVID-19
Status: UNKNOWN
Conditions: COVID-19 Thalidomide
Interventions: DRUG: placebo|DRUG: Thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thromboprophylaxis in Patients Undergoing Orthopedic Surgeries; Using Propensity Score Matching
Status: UNKNOWN
Conditions: Thrombosis|Deep Vein Thrombosis|Surgery--Complications
Interventions: DRUG: Xarelto (rivaroxaban)|DRUG: Lovenox (enoxaparin)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ArterX Surgical Sealant, A Randomized Prospective Multicenter Trial
Status: COMPLETED
Conditions: Vascular Disease
Interventions: DEVICE: ArterX Surgical Sealant|DEVICE: Gelfoam and Thrombin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism (RESCUE)-Japan RCT
Status: TERMINATED
Conditions: Ischemic Stroke
Interventions: PROCEDURE: Rescue endovascular therapy|PROCEDURE: No endovascular therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fatigue in Multiple Sclerosis: Evaluated With 3 MRI and Transcranial Magnetic Stimulation
Status: COMPLETED
Conditions: Multiple Sclerosis|Fatigue
Interventions: DRUG: 3,4-diaminopyridine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Helicobacter Pylori and Lacidophilin Tablets in Combination With Vonorazan Dual Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Lacidophilin tablets in combination with vonorazan dual therapy|DRUG: Placebo in combination with vonorazan dual therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Sclerotherapy and/or Ligation Versus Portacaval Shunt for Bleeding Gastric Varices
Status: COMPLETED
Conditions: Gastric Bleeding|Cirrhosis
Interventions: PROCEDURE: Portacaval shunt|PROCEDURE: Sclerotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Carisbamate Safety Study in Adult and Pediatric Subjects With Lennox-Gastaut Syndrome
Status: COMPLETED
Conditions: Lennox Gastaut Syndrome
Interventions: DRUG: Carisbamate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Therapeutic Confirmatory Clinical Trial to Evaluate the Safety and Efficacy of "Hugeltox Inj." in Essential Blepharospasm
Status: COMPLETED
Conditions: Essential Blepharospasm
Interventions: DRUG: Hugeltox|DRUG: Botulinum Toxin Type A(Botox®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pazopanib Plus Lapatinib Compared to Lapatinib Alone and Pazopanib Alone In Subjects With Metastatic Cervical Cancer
Status: COMPLETED
Conditions: Neoplasms, Uterine Cervix|Metastatic Cervical Cancer
Interventions: DRUG: pazopanib (GW786034)|DRUG: lapatinib (GW572016)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erigo®Pro Coma Outcome Study - Study on the Effectiveness of a Robotic Tilt Table Device for Recovery of Consciousness
Status: COMPLETED
Conditions: Brain Injuries|Disorders of Consciousness
Interventions: BEHAVIORAL: Standard physiotherapy|DEVICE: Erigo®Pro group without FES|DEVICE: Erigo®Pro group with FES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Photorefraction With Cycloautorefraction and Cycloretinoscopy at Emam Hosein Medical Centre in 2008-2009
Status: COMPLETED
Conditions: Amblyopia
Interventions: DEVICE: photorefraction,cycloautorefraction,cycloretinoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: Improving Patient Memory for Treatment for Mild Cognitive Impairment
Status: RECRUITING
Conditions: Memory Impairment|Sleep Disorder
Interventions: BEHAVIORAL: Transdiagnostic sleep and circadian intervention (TranS-C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: TADCLOT- a Double Blind Randomized Controlled Trial
Status: RECRUITING
Conditions: Stent Thrombosis|Myocardial Infarction, Acute
Interventions: DRUG: Ticagrelor 90 MG|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Elective Regional Lymph Node Irradiation in N1 Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Neoplasm
Interventions: RADIATION: Whole breast irradiation|RADIATION: Whole breast and nodal irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ABSORB II Randomized Controlled Trial
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Abbott Vascular XIENCE Everolimus Eluting Coronary Stent System|DEVICE: Abbott Vascular ABSORB Everolimus Eluting Bioresorbable Vascular Scaffold System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of GXR as Adjunctive Therapy With Psycho-stimulant on Executive Function in Children With ADHD
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Guanfacine extended release|DRUG: Placebo|DRUG: Stimulant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of BCMA/CD19 Dual-Target CAR-T Cell Immunotherapy for Relapsed or Refractory Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: BCMA/CD19 Dual-Target CAR-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palbociclib and Cetuximab Versus Cetuximab Monotherapy for Patients With CDKN2A-altered, HPV-unrelated Head and Neck Squamous Cell Carcinoma Who Experienced Disease Progression on a PD-1/L1 Inhibitor
Status: RECRUITING
Conditions: HPV-unrelated Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Palbociclib|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Achilles Tendinosis Study; Comparison of Radiofrequency to Surgical MicroDebridement
Status: COMPLETED
Conditions: Achilles Pain|Achilles Tendinosis|Heel Pain
Interventions: DEVICE: plasma microdebrider|PROCEDURE: Mechanical Surgical Debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pazopanib in Treating Patients With Recurrent Glioblastoma
Status: COMPLETED
Conditions: Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Recurrent Adult Brain Tumor
Interventions: DRUG: pazopanib hydrochloride|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Lung Exposure Bioequivalence of Budesonide, Glycopyrronium, & Formoterol (BGF) Metered Dose Inhaler (MDI) Hydrofluoroolefin (HFO) With a Spacer (Treatment B), BGF MDI Hydrofluoroalkane (HFA) With a Spacer (Treatment A), as Well as BGF MDI HFO Without a Spacer (Treatment C)
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DRUG: Treatment A: BGF MDI HFA|DRUG: Treatment B: BGF MDI HFO|DRUG: Treatment C: BGF MDI HFO|DEVICE: AeroChamber Plus Flow-Vu Spacer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Internal Jugular Vein Ultrasound Measures and Fluid Responsiveness in Post-Operative Cardiac Surgical Patients
Status: COMPLETED
Conditions: Fluid Therapy|Cardiac Surgical Procedures
Interventions: PROCEDURE: Volume challenge|PROCEDURE: Ultrasound evaluation of internal jugular vein
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: An Efficacy and Safety Study of Ontamalimab as Maintenance Therapy in Participants With Moderate to Severe Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Ontamalimab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Restylane Silk Acne Scar Efficacy Evaluation Study
Status: TERMINATED
Conditions: Acne|Acne Scars|AdverseEvent
Interventions: DEVICE: Restylane Silk, 1.0 ml|DEVICE: Saline, 1.0 ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Guided Versus Conventional Periapical Endodontic Surgery
Status: UNKNOWN
Conditions: Endodontic Disease|Endodontic Re-treatment Failure
Interventions: DEVICE: 3D guide|DEVICE: Mock guide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Tolerance of 2 Acne Treatment Regimens on Subjects With Mild to Moderate Acne
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DEVICE: Cleanser, Acne Mask|DEVICE: Cleanser, Gel-Cream, Acne Mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility Assessment of the Bio-electrical One Day Capsule System in Overweight and Class I Obese Participants
Status: SUSPENDED
Conditions: Overweight and Obesity
Interventions: DEVICE: ODC system (type 1 capsule)|DEVICE: ODC system (type 2 capsule)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Comparing Effectiveness of Buffered Versus Unbuffered Local Anesthetic in Children Ages 10-12 Years
Status: COMPLETED
Conditions: Anesthesia, Local|Pain
Interventions: DRUG: 1% Buffered Lidocaine 1:100,000 Epinephrine|DRUG: 2% Unbuffered Lidocaine 1:100,000 Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Impact of Adalimumab Therapy on Brachial Endothelial Function and Large Artery Stiffness in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DEVICE: transthoracic echocardiographic|DEVICE: Doppler ultrasound.|BIOLOGICAL: blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Human Papilloma Virus (HPV) Vaccine Efficacy Trial Against Cervical Pre-cancer in Young Adults With GlaxoSmithKline (GSK) Biologicals HPV-16/18
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: BIOLOGICAL: Cervarix™|BIOLOGICAL: Havrix™-based investigational formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Utilization of Narrow Band Ultraviolet B (UVB) Light Therapy and Etanercept for the Treatment of Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DEVICE: NB-UVB|DRUG: Etanerept|DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non Inferiority Study of Preoperative Chemotherapy Without Pelvic Irradiation for Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer|Advanced Cancer
Interventions: DRUG: Chemotherapy|DRUG: Radiochemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of a Dendritic Cell Vaccine in HIV-1 Infected Subjects
Status: COMPLETED
Conditions: HIV-1 Infection|HIV Infections
Interventions: BIOLOGICAL: mRNA-transfected autologous dendritic cells|BIOLOGICAL: autologous dendritic cells with no mRNA transfection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Efficacy and Safety of Oral Tazemetostat in Adult Participants With Relapsed/Refractory Follicular Lymphoma That Does Not Have an "EZH2 Gain-of-function" Genetic Mutation
Status: NOT_YET_RECRUITING
Conditions: Follicular Lymphoma|Refractory Follicular Lymphoma
Interventions: DRUG: Tazverik (Tazemetostat)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Navigator Trial
Status: COMPLETED
Conditions: Opioid Use|Opioid Dependence|Opioid Abuse|Opioid-Related Disorders
Interventions: BEHAVIORAL: Peer Navigator Intervention|BEHAVIORAL: Social Work Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-cohort Study of Safety, Efficacy, PK and PD of GNR-055 in Patients With Mucopolysaccharidosis Type II
Status: RECRUITING
Conditions: Mucopolysaccharidosis Type II|Metabolic Diseases
Interventions: DRUG: GNR-055 1.0-2.0-3.0 mg/kg|DRUG: GNR-055 2.0 mg/kg|DRUG: GNR-055 3.0 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IRX-2 Regimen Combined With Nivolumab in Recurrent/Metastatic Solid Tumors
Status: COMPLETED
Conditions: Metastatic Cancer|Recurrent Cancer|Solid Tumor|Renal Cell Carcinoma|Urothelial Carcinoma|NSCLC|Squamous Cell Carcinoma|Non-Small Cell Lung Cancer|Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: IRX 2|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Lysulin on Glycemic Control and Advanced Glycation
Status: TERMINATED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Lysulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Assess Brincidofovir Treatment of Serious Diseases or Conditions Caused by Double-stranded DNA Viruses
Status: COMPLETED
Conditions: Double-stranded DNA Virus
Interventions: DRUG: Brincidofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Olanzapine With or Without Fosaprepitant Dimeglumine in Preventing Chemotherapy Induced Nausea and Vomiting in Cancer Patients Receiving Highly Emetogenic Chemotherapy
Status: COMPLETED
Conditions: Malignant Neoplasm
Interventions: DRUG: Palonosetron Hydrochloride|DRUG: Ondansetron Hydrochloride|DRUG: Dexamethasone|DRUG: Fosaprepitant Dimeglumine|DRUG: Olanzapine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Prospective Researcher-led Clinical Study of Neopep-S-based EasyDew MD Regen Cream
Status: COMPLETED
Conditions: Skin Lesion
Interventions: DEVICE: EasyDew MD regen cram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Amifostine With or Without Epoetin Alfa in Treating Patients With Myelodysplastic Syndrome
Status: UNKNOWN
Conditions: Anemia|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: epoetin alfa|DRUG: amifostine trihydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy Trial of Intracranial Aneurysm Treatment Using Two Different Endovascular Techniques
Status: UNKNOWN
Conditions: Intracranial Aneurysms
Interventions: DEVICE: Endovascular treatment of intracranial aneurysms|DEVICE: Endovascular treatment of intracranial aneurysm with coils
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Bowel Syndrome Research Study for Children Up To 17 Years of Age on Parenteral Nutrition
Status: COMPLETED
Conditions: Short Bowel Syndrome
Interventions: DRUG: Teduglutide 0.05mg/kg|DRUG: Teduglutide 0.025 mg/kg|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid Endarterectomy (TCD Part)
Status: RECRUITING
Conditions: Carotid Endarterectomy
Interventions: DRUG: Ephedrine|DRUG: Phenylephrine|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neurosensorial Disorder and Pain in Oral Cavity and Oropharynx Cancer Traited Patients (OCAPA)
Status: RECRUITING
Conditions: Head Cancer|Neck Cancer|Chronic Pain
Interventions: DIAGNOSTIC_TEST: diagnostic tes for neuropathic pain
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 2 Study to Evaluate Immune Responses of FluMist®
Status: COMPLETED
Conditions: Influenza Vaccine
Interventions: BIOLOGICAL: TIV, Trivalent Inactivated Influenza Virus Vaccine|BIOLOGICAL: FluMist, Influenza Virus Vaccine Live
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effective Maneuver for Post-laparoscopic Shoulder Pain
Status: COMPLETED
Conditions: Gynecologic Diseases
Interventions: PROCEDURE: Passive Deflation|PROCEDURE: Normal Saline Instillation|PROCEDURE: Normal Saline Instillation + Pulmonary Recruitment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Coronary Luminal Diameter Enlargement With Emerge™ 1.20 mm PTCA Dilatation Catheter
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Emerge™ 1.20 mm PTCA Dilatation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cesarean Scar Characteristics After Scheduled and Emergency Cesarean Deliveries
Status: COMPLETED
Conditions: Cesarean Scar Niche|Cesarean Wound; Dehiscence|Cesarean Section; Dehiscence
Interventions: RADIATION: Ultrasound assessement of uterine scar
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multimodal Orthognathic Study Comparing Use of Exparel With Standard of Care.
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Liposomal bupivacaine|DRUG: Bupivacain|DRUG: Epinephrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Combination of Daratumumab and BD Regimen and Dapagliflozin in the Treatment of M-protein Related Cardiac Disease
Status: NOT_YET_RECRUITING
Conditions: M-protein Related Cardiac Disease
Interventions: DRUG: Daratumumab + Bortezomib + Dexamethasone + Dapagliflozin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dex on Microcirculation in SS-A Double-blinded Study
Status: UNKNOWN
Conditions: Septic Shock
Interventions: DRUG: Dexmedetomidine for dexmedetomidine group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of HRS-9231 Safety and Pharmacokinetics in Healthy Caucasians
Status: RECRUITING
Conditions: MRI
Interventions: DRUG: HRS-9231or matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Acupuncture in Macular Diseases
Status: COMPLETED
Conditions: Age-related Macular Degeneration|Stargardt Disease|Macular Dystrophy
Interventions: OTHER: Acupuncture and massage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Different Priming Solutions Effects on Microcirculation, Oxidative Stress and Morbidity in Cardiovascular Surgery Patients
Status: COMPLETED
Conditions: Microcirculation
Interventions: OTHER: priming solution during cardiovascular surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxyethyl Starch 130/0.4 and Sodium Chloride Injection as Adjunctive Therapy in Subjects With Internal Carotid Artery Hypoperfusion
Status: UNKNOWN
Conditions: Brain Hypoperfusion
Interventions: DRUG: hydroxyethyl starch 130/0.4 and sodium chloride injection|DRUG: hydroxyethyl starch 130/0.4 and sodium chloride injection|DRUG: hydroxyethyl starch 130/0.4 and sodium chloride injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Study on the Treatment of Chronic Obstructive Pulmonary Disease With Autologous Bronchial Basal Cell Transplantation
Status: COMPLETED
Conditions: Cell Transplantation
Interventions: OTHER: autologous bronchial basal cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Team Effectiveness for a Collaborative School-based Intervention for ADHD
Status: RECRUITING
Conditions: Team-effectiveness Research|School-based Interventions|Attention Deficit/ Hyperactivity Disorder|Implementation Science
Interventions: BEHAVIORAL: Team-Enhanced Collaborative Life Skills Program|BEHAVIORAL: Standard Collaborative Life Skills Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Pharmacokinetic Study of Pirfenidone Modified-Release Tablets in Healthy Subjects Under Fasting and Fed Conditions
Status: NOT_YET_RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Pirfenidone Modified-Release Tablets|DRUG: Pirfenidone Modified-Release Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 2 Sequential and Concurrent Chemoradiation for Advanced Nasopharyngeal Carcinoma (NPC)
Status: COMPLETED
Conditions: Stage II Lymphoepithelioma of the Nasopharynx|Stage II Squamous Cell Carcinoma of the Nasopharynx|Stage III Lymphoepithelioma of the Nasopharynx|Stage III Squamous Cell Carcinoma of the Nasopharynx|Stage IV Lymphoepithelioma of the Nasopharynx|Stage IV Squamous Cell Carcinoma of the Nasopharynx
Interventions: DRUG: docetaxel|DRUG: cisplatin|DRUG: carboplatin|DRUG: fluorouracil|RADIATION: 3-dimensional conformal radiation therapy|RADIATION: intensity-modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: US-guided Percutaneous Electrolysis (EPE®) in Shoulder Pain
Status: COMPLETED
Conditions: Shoulder Pain
Interventions: OTHER: US-guided percutaneous electrolysis|OTHER: Eccentric exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CBD Oil for Reducing Emotional Impact of COVID-19
Status: SUSPENDED
Conditions: Anxiety Depression|Alcohol Abuse|Substance Abuse|Anger|Sleep Disturbance|Stress Reaction
Interventions: DIETARY_SUPPLEMENT: CBD Isolate|DIETARY_SUPPLEMENT: Full Spectrum CBD Oil|DIETARY_SUPPLEMENT: Broad-Spectrum CBD Oil|DIETARY_SUPPLEMENT: Placebo Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Polar Body Removal Before ICSI for Oocyte Activation in Previous Fertilization Failure Cases
Status: COMPLETED
Conditions: Fertilization
Interventions: PROCEDURE: polar body removal using zona drilling by laser then suction by injecting pipette|PROCEDURE: Classic ICSI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 4 Clinical Study of Brodalumab
Status: COMPLETED
Conditions: Psoriasis Vulgaris|Psoriatic Arthritis|Pustular; Psoriasis, Palmaris Et Plantaris|Psoriatic Erythroderma
Interventions: DRUG: Brodalumab 210mg SC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Avotermin (Juvista) in Female Subjects
Status: COMPLETED
Conditions: Cicatrix|Wound Healing
Interventions: DRUG: Avotermin|DRUG: Avotermin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Longitudinal Validation of a Computerized Cognitive Battery (Cognigram) in the Diagnosis of Mild Cognitive Impairment and Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer Disease|Dementia|Neuropathology|Mild Cognitive Impairment
Interventions: DEVICE: Computerized cognitive battery: Cognigram (CG)|DEVICE: The NeuroCatch™ Platform (NCP)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Targeting Cognition in PTSD: Pregnenolone Augmentation of SSRIs
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic
Interventions: DRUG: Pregnenolone or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to Basal Insulin Alone or Basal Insulin in Combination With Metformin in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: semaglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GEN1046 Safety Trial in Patients With Malignant Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumors|Non-small Cell Lung Cancer|Urothelial Carcinoma|Endometrial Carcinoma|Triple Negative Breast Cancer|Squamous Cell Carcinoma of the Head and Neck|Cervical Cancer
Interventions: BIOLOGICAL: Acasunlimab|BIOLOGICAL: Acasunlimab in combination with docetaxel (in a single expansion cohort)|BIOLOGICAL: Acasunlimab in combination with pembrolizumab (in a separate expansion cohort)|BIOLOGICAL: Acasunlimab in combination with pembrolizumab and standard chemotherapy (in separate expansion cohorts)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Cetuximab as First-Line Therapy in Treating Patients With Advanced and/or Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: capecitabine|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The PAIN (Pelvic Area Injection for Numbness) Study
Status: RECRUITING
Conditions: Vaginal Laceration During Delivery
Interventions: DRUG: Bupivacaine|DRUG: Epinephrine|OTHER: Sham normal saline arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Randomized, Placebo-Controlled Phase 2 Study to Evaluate the Clinical Efficacy, Safety, and Tolerability of ARX-F01 Sublingual Sufentanil in Patients Undergoing Major Abdominal Surgery
Status: COMPLETED
Conditions: Major Upper or Lower Abdominal Surgery
Interventions: DRUG: Oral sufentanil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study on USS Assessment of Pelvic Structures in 3rd Trimester of Pregnancy Versus Delivery Outcome
Status: COMPLETED
Conditions: Pelvic Floor Disorders|Pregnancy
Interventions: PROCEDURE: ultrasound|PROCEDURE: uroflow-meter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: RCT of Uniport VATS for Lung Cancer
Status: RECRUITING
Conditions: Single-port Video-assisted Thoracoscopic Surgery
Interventions: PROCEDURE: uniport video-assisted thoracoscopic surgery|PROCEDURE: two ports video-assisted thoracoscopic surgery|PROCEDURE: three ports video-assisted thoracoscopic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neo-adjuvant Chemoradiation With Oxaliplatin/5-FU in Rectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: 5-FU|DRUG: Oxaliplatin|DRUG: leucovorin|PROCEDURE: mesorectal excision
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Chest Physiotherapy (CPT) on Lung Clearance Index (LCI) in Non Cystic Fibrosis (CF) Bronchiectasis
Status: COMPLETED
Conditions: Bronchiectasis
Interventions: OTHER: Autogenic drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT