pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Heartland Osteoporosis Prevention Study
Status: COMPLETED
Conditions: Osteopenia
Interventions: DRUG: Calcium Carbonate|DRUG: Vitamin D3|DRUG: Risedronate|BEHAVIORAL: Bone-loading exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NIRS and Doppler to Predict NEC in Risk Neonates
Status: UNKNOWN
Conditions: Necrotizing Enterolitis
Interventions: DEVICE: Cerebral and splanchnic ear infrared spectroscopy (NIRS) and mesenteric Doppler
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Targeted Alpha Therapy With 225Actinium-Prostate Specific Membrane Antigen (PSMA)-I&T of Castration-resISTant Prostate Cancer (TATCIST).
Status: RECRUITING
Conditions: Metastatic Castration Resistant Prostate Cancer
Interventions: DRUG: FPI-2265
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Therapeutic Role of Intravenous Albumin Administration for Peptic Ulcer Bleeding Patients With Hypoalbuminemia
Status: COMPLETED
Conditions: Peptic Ulcer Bleeding|Hypoalbuminemia
Interventions: DRUG: Human albumin|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet-delivered Cognitive Behaviour Therapy for Sleep Problems in ASD
Status: NOT_YET_RECRUITING
Conditions: Autism Spectrum Disorder|Sleep Disturbance|Insomnia
Interventions: BEHAVIORAL: Internet-based CBT-I|BEHAVIORAL: Internet-based psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Effects of Four Types of Electroconvulsive Therapy on Mood and Thinking in People With Depression
Status: COMPLETED
Conditions: Depression
Interventions: DEVICE: Electroconvulsive Therapy (ECT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study to Examine Whether Echocardiography Performed During Cardiac Resynchronization Therapy Device Implantation Can Improve the Response Rate
Status: WITHDRAWN
Conditions: Heart Failure|Cardiac Resynchronization Therapy|Echocardiography
Interventions: DEVICE: Empirical group|DEVICE: Echocardiography-guided approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Spinal Cord Stimulation With Bladder and Pelvic Floor Muscle Training
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: OTHER: Bladder and Pelvic Floor Muscle Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Azacitidine and Lenalidomide for Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: Lenalidomide|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Label Study of Oral Minocycline for the Treatment of Patients With Co-occurring Opioid and ATS Dependence
Status: UNKNOWN
Conditions: Heroin Dependence|Amphetamine Dependence
Interventions: DRUG: Minocycline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: U-LABA/ICS Effects on Exercise Performance, Indacaterol
Status: RECRUITING
Conditions: Exercise Performance
Interventions: DRUG: Indacaterol and Mometasonefluroate (low dose)|DRUG: Placebo|DRUG: Indacaterol and Mometasonefluroate (high dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: New Markers of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Function in Sweat
Status: UNKNOWN
Conditions: Cystic Fibrosis|Biomarkers
Interventions: DIAGNOSTIC_TEST: Sweat test (Macroduct Sweat Collection System) and skin biopsy (Punch Biopsy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Fistulectomy and Primary Sphincter rEconstruction vs. endorectaL Advancement Flap in the Treatment of High Anal Fistulas
Status: UNKNOWN
Conditions: Anal Fistula
Interventions: PROCEDURE: Muco-muscular endorectal advancement flap after fistulectomy|PROCEDURE: Primary sphincter reconstruction after fistulectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: STrategies of Scheduled Drug-coated Balloons (DCB) Versus Conventional DES for the interveNTional Therapy of de Novo Lesions in Large Coronary vESSels (STENTLESS) Trial
Status: RECRUITING
Conditions: Drug-coated Balloon|Drug-eluting Stent|De Novo Stenosis
Interventions: DEVICE: Drug-coated balloon (Bingo© [Paclitaxel-coated Balloon], Yinyi Ltd., China)|DEVICE: Drug-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing Women's Attitudes About the Risk of Infertility Related to Adjuvant Therapy for Early Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Psychosocial Effects of Cancer and Its Treatment|Sexual Dysfunction and Infertility|Sexuality and Reproductive Issues
Interventions: PROCEDURE: psychosocial assessment and care
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Alberta Collaborative QI Strategies to Improve Outcomes of Moderate and Late Preterm Infants (ABC-QI Trial)
Status: RECRUITING
Conditions: Length of Stay
Interventions: BEHAVIORAL: QI Team Building|BEHAVIORAL: QI education|OTHER: Standardized care bundle- respiratory care|OTHER: Standardized care bundle- nutritional care|BEHAVIORAL: QI mentoring|BEHAVIORAL: Collaborative networking|OTHER: Current practice- standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Central Nervous System Focused Treatment Approach for Frozen Shoulder
Status: COMPLETED
Conditions: Adhesive Capsulitis of Shoulder|Frozen Shoulder
Interventions: OTHER: CNS-focused treatment|OTHER: Standard Care Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Different Resin Composite Restorations
Status: UNKNOWN
Conditions: Dental Caries
Interventions: OTHER: sonic fill 3 & PALFIQUE bulk flow & Neo spectra & Clear fill AP-X
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spontaneous Retinal Artery Pulses (SPARs) as a Prognostic Determinant of Central Retinal Vein Occlusions (CRVO) in Patients With or Without Intravitreal Aflibercept Injections
Status: ACTIVE_NOT_RECRUITING
Conditions: Central Retinal Vein Occlusion
Interventions: OTHER: Ophthalmologic exam at inclusion and 12 months after CRVO|DRUG: Treatment standardization with aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prone Positioning During High Flow Oxygen Therapy in Acute Hypoxemic Respiratory Failure
Status: COMPLETED
Conditions: Respiratory Failure With Hypoxia|Respiratory Failure Without Hypercapnia
Interventions: PROCEDURE: Prone position
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Home-based Module to Promote Mindful Breathing Awareness for COPD Patients
Status: COMPLETED
Conditions: COPD
Interventions: BEHAVIORAL: Home-based pulmonary rehabilitation program|BEHAVIORAL: Mindful breathing module|BEHAVIORAL: Health coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Newly Diagnosed Glioblastoma
Status: UNKNOWN
Conditions: Glioblastoma
Interventions: DRUG: Anlotinib Hydrochloride|DRUG: Placebo|RADIATION: Radiation Therapy|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnesium Sulfate Versus Nifedipine for the Acute Tocolysis of Preterm Labor: A Prospective, Randomized Trial
Status: COMPLETED
Conditions: Obstetric Labor, Premature
Interventions: DRUG: Magnesium Sulfate|DRUG: Nifedipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Safety and Tolerability of Fevipiprant Delivered Via a Once Daily Chewable Tablet in Children Aged 6 to < 12 Years With Asthma
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: Fevipiprant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Neural Mechanism of Naoan Dripping Pills for Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Naoan dripping pills|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dynamic Area Telethermometry (DAT) as an Imaging Modality in Patients With Cancer
Status: COMPLETED
Conditions: Malignant Tumors|Subcutaneous Tumors|Lymph Node Tumors
Interventions: PROCEDURE: Dynamic Area Telethermometry (DAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Yoga Program for Patients Undergoing Prostate Cancer Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Prostate Cancer|Erectile Dysfunction|Urinary Incontinence
Interventions: BEHAVIORAL: Yoga|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Pharmacokinetic Comparison of Co-administration and a Combination Drug of Rosuvastatin and Olmesartan in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Test formulation|DRUG: Reference formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Dexmedetomidine Versus Ketamine in Multiple Fracture Ribs
Status: RECRUITING
Conditions: Rib Fractures
Interventions: DRUG: Dexmedetomidine|DRUG: Ketamine|OTHER: 0.9% saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Risk of Revision Following Knee Arthroplasty in Bariatric Surgery Patients
Status: NOT_YET_RECRUITING
Conditions: Arthritis Knee|Bariatric Surgery Candidate|Prosthesis Failure|Prosthesis Survival|Prosthesis-Related Infections
Interventions: OTHER: BAS|OTHER: Non-BAS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation and Characterization of Behavioural Disorders and Dementias by the Behavioural Dysexecutive Syndrome Inventory (BDSI)
Status: COMPLETED
Conditions: Frontotemporal Dementia|Huntington Disease|Alzheimer Disease|Semantic Dementia|Dementia, Vascular
Interventions: BEHAVIORAL: prevalence of behavioural dysexecutive syndrome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Life 4°C Versus Optisol in Corneal Storage Media
Status: COMPLETED
Conditions: Complications of Corneal Transplant
Interventions: OTHER: Corneal donor storage in Optisol GS media solution|OTHER: Life 4°C solution for cornea storage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Spine Fusion Instrumented With BMP-2 vs Uninstrumented With Infuse BMP-2 Alone
Status: COMPLETED
Conditions: Degenerative Lumbar Disc Disease|Spondylolisthesis|Spinal Stenosis
Interventions: PROCEDURE: Device used in surgery with or without instrumentation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravesicular Onabotulinumtoxin A in Interstitial Cystitis
Status: COMPLETED
Conditions: Interstitial Cystitis
Interventions: DRUG: Onabotulinumtoxin A|PROCEDURE: injections upper aspect of trigone of urinary bladder|PROCEDURE: injections on posterior bladder wall excluding the trigone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Anti-Disease Activity of CHR-2797 (Tosedostat) in Elderly and/or Treatment Refractory Patients With Acute Myeloid Leukemia (AML) and Multiple Myeloma (MM)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome|Multiple Myeloma
Interventions: DRUG: CHR-2797 (tosedostat): Aminopeptidase inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Malnutrition in Older Adults: An Intervention Based on Medication Review and Individual Nutritional Plan
Status: UNKNOWN
Conditions: Malnutrition|Polypharmacy|Aged
Interventions: DIETARY_SUPPLEMENT: Individualized plan for improvement of nutrition|DRUG: Systematic drug review
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Efficacy of a Single Dose of a Dengue Vaccine (TV005) in Healthy Adults
Status: COMPLETED
Conditions: Dengue
Interventions: BIOLOGICAL: TV005|BIOLOGICAL: Placebo|BIOLOGICAL: rDEN2∆30-7169
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant
Status: COMPLETED
Conditions: Childhood Acute Lymphoblastic Leukemia in Remission|Childhood Acute Myeloid Leukemia in Remission|Childhood Chronic Myelogenous Leukemia|Childhood Myelodysplastic Syndromes|Chronic Eosinophilic Leukemia|Chronic Myelomonocytic Leukemia|Chronic Neutrophilic Leukemia|de Novo Myelodysplastic Syndromes|Disseminated Neuroblastoma|Juvenile Myelomonocytic Leukemia|Mucositis|Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable|Previously Treated Childhood Rhabdomyosarcoma|Previously Treated Myelodysplastic Syndromes|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Rhabdomyosarcoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Malignant Testicular Germ Cell Tumor|Recurrent Wilms Tumor and Other Childhood Kidney Tumors|Recurrent/Refractory Childhood Hodgkin Lymphoma|Relapsing Chronic Myelogenous Leukemia|Secondary Acute Myeloid Leukemia|Secondary Myelodysplastic Syndromes|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: supersaturated calcium phosphate rinse|OTHER: placebo|OTHER: questionnaire administration|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Carbamazepine on the Pharmacokinetics (PK) of AT-527
Status: COMPLETED
Conditions: Healthy Volunteer Study
Interventions: DRUG: Period 1: AT-527 550 mg|DRUG: Period 2: carbamazepine|DRUG: Period 3: AT-527 550 mg + carbamazepine|DRUG: Period 3: AT-527 1100 mg + carbamazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-operative Ketamine Infusions in Opioid-dependent Patients With Chronic Lower Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: DRUG: Ketamine|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Oral Health and Quality of Life Associated With Use of a Denture Adhesive
Status: COMPLETED
Conditions: Denture Retention
Interventions: DRUG: Experimental Denture Adhesive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Characterization of the Pharmacodynamic Response to Vaped THC
Status: WITHDRAWN
Conditions: Vaping|THC
Interventions: DRUG: THC or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of a Female Hormone Balance Supplement on Symptoms of Polycystic Ovary Syndrome and Severe Premenstrual Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Premenstrual Syndrome
Interventions: DIETARY_SUPPLEMENT: Female Hormone Balance Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Oral Deuremidevir Hydrobromide for Suspension
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: DRUG: Deuremidevir Hydrobromide for Suspension|DRUG: Deuremidevir Hydrobromide for Suspension Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Newborn Pain and Stress Levels in Oxytocin Induction at Birth
Status: COMPLETED
Conditions: Induced Vaginal Delivery
Interventions: BEHAVIORAL: Oxytocin induction group|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Health Information Technology for COVID-19 Testing in Schools (SCALE-UP Counts)
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BEHAVIORAL: Text Messaging (TM)|BEHAVIORAL: Text Messaging + Health Navigation (TM+HN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Tka Assay for CDK4/6i
Status: RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Metastatic HER2-Negative Breast Carcinoma
Interventions: DEVICE: DiviTum-TKa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Premedication Dyclonine Improves Visibility During Bowel Cleansing for Colonoscopy
Status: UNKNOWN
Conditions: Bowel Preparation Scale|the Amount of Air Bubble|Adenoma Detection Rate
Interventions: DRUG: 3L PEG|DRUG: 3L PEG+Dyclonine Hydrochloride Mucilage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Safety of Autologous Cord Blood Cells for Preterm Infants.
Status: COMPLETED
Conditions: Safety Issues|Effect of Drugs|Neonatal Death
Interventions: COMBINATION_PRODUCT: Autologous Umbilical Cord Blood Stem Cells Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase 4 Study to Evaluate Treatment Optimization With Once-daily Insulin Glargine 300 U/mL
Status: COMPLETED
Conditions: Type I Diabetes Mellitus
Interventions: DRUG: INSULIN GLARGINE (U300)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Assess the Safety, In-use Tolerability of Test Product in Healthy Adult Subjects With Dry and Sensitive Skin.
Status: NOT_YET_RECRUITING
Conditions: Dry Skin|Sensitive Skin
Interventions: OTHER: No Rays, Thanks Mineral sunscreen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Adebrelimab Combined With Bevacizumab and Docetaxel for Advanced Non-Squamous Non-small Cell Lung Cancer After Progression on First-line Immunotherapy
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Adebrelimab Combined with Bevacizumab and Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Azithromycin to Prevent Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation
Status: UNKNOWN
Conditions: Malignant Hematological Diseases
Interventions: DRUG: Azithromycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Glucose Variability and Cognition in Prediabetes
Status: RECRUITING
Conditions: Glucose Metabolism Disorders (Including Diabetes Mellitus)|Cognitive Decline|Functional Status|PreDiabetes|Aging|Depression
Interventions: DEVICE: Continuous Glucose Monitoring System (CGMS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Electrochemotherapy as a Palliative Treatment for Brain Metastases
Status: TERMINATED
Conditions: Brain Metastases|CNS Metastases
Interventions: DEVICE: The Electroporation System|DRUG: Bleomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spinal Versus Caudal Analgesia After Pediatric Infra-umbilical Surgery
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Intrathecal hyperbaric bupivacaine 0.25mg/kg 0.5%|DRUG: caudal plain bupivacaine 2.5mg/kg 0.25%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Splanchnic and Renal Tissue Oxygenation During Enteral Feedings in Neonates With Patent Ductus Arteriosus
Status: COMPLETED
Conditions: Infant, Premature|Congenital Heart Disease|Patent Ductus Arteriosus|Necrotizing Enterocolitis
Interventions: PROCEDURE: Near-infrared spectroscopy (NIRS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Patient Derived Cancer Cell Lines in Identifying Molecular Changes in Patients With Previously Untreated Pancreatic Cancer Receiving Gemcitabine Hydrochloride-Based Chemotherapy
Status: WITHDRAWN
Conditions: Pancreatic Ductal Adenocarcinoma|Stage IA Pancreatic Cancer|Stage IB Pancreatic Cancer|Stage IIA Pancreatic Cancer|Stage IIB Pancreatic Cancer|Stage III Pancreatic Cancer|Stage IV Pancreatic Cancer
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Cytology Specimen Collection Procedure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Gaming Apps Post-Stroke
Status: WITHDRAWN
Conditions: Stroke|Cognitive Impairment|Executive Dysfunction|Cognitive Change|Cognitive Deficit
Interventions: OTHER: Mobile or tablet-based gaming applications|OTHER: Stroke-related educational videos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Personalized mRNA Vaccine Encoding Neoantigen in Combination With Standard First-line Treatment in Subjects With Advanced Digestive System Neoplasms
Status: RECRUITING
Conditions: Digestive System Neoplasms
Interventions: BIOLOGICAL: iNeo-Vac-R01
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Riboflavin for Glutamate Reduction in Alcohol Withdrawal
Status: UNKNOWN
Conditions: Alcohol Withdrawal|Nutrition Disorders|Alcohol Use Disorder
Interventions: DRUG: Riboflavin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Celiac Plexus Block for Chronic Pancreatitis RCT
Status: TERMINATED
Conditions: Pancreatitis, Chronic|Pancreatitis
Interventions: PROCEDURE: Celiac Block with triamcinolone and bupivicaine|PROCEDURE: No Celiac Block|DRUG: Intra Plexus Triamcinolone and Bupivicaine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Drug-drugs Interaction Between Lobeglitazone 0.5mg and Empagliflozin 25mg
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: CKD-398|DRUG: CKD-501, D745
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PPALM-Palm Oil and Pentoxifylline Against Late Morbidity
Status: COMPLETED
Conditions: Long-term Adverse Effects of Radiotherapy for Pelvic Cancer
Interventions: DRUG: Tocovid SupraBio plus pentoxifylline|DRUG: Matching placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Favipiravir Tablets Combine With Chloroquine Phosphate in the Treatment of Novel Coronavirus Pneumonia
Status: UNKNOWN
Conditions: Novel Coronavirus Pnuemonia
Interventions: DRUG: favipiravir tablets+chloroquine phosphatetablets tablets|DRUG: Favipiravir tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Primary & Booster Immunogenicity Study of GSK Biologicals' Hib-MenC Versus a Licensed Men-C Vaccine
Status: COMPLETED
Conditions: Haemophilus Influenzae Type b|Neisseria Meningitidis
Interventions: BIOLOGICAL: Haemophilus influenzae type b- and meningococcal (vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Lenalidomide in Combination With Melphalan and Dexamethasone in Newly-diagnosed Light-chain (AL)-Amyloidosis
Status: COMPLETED
Conditions: Amyloidosis
Interventions: DRUG: Lenalidomide|DRUG: Melphalan|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thrust Manipulation vs. Non-thrust Mobilizations for Mechanical Neck Pain
Status: UNKNOWN
Conditions: Neck Pain
Interventions: OTHER: Home Exercise Program|OTHER: Patient advice, encouragement, and education|OTHER: Thrust Manipulation|OTHER: Non-thrust Mobilizations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans
Status: ACTIVE_NOT_RECRUITING
Conditions: Major Depressive Disorder|Epilepsy
Interventions: DEVICE: Intracranial electrodes|DEVICE: TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: CKD-828 Telmisartan Non-Responder Trial
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: CKD-828 40/2.5mg|DRUG: CKD-828 40/5mg|DRUG: Telmisartan 80mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study to Evaluate Safety, Tolerability, and Immunogenicity of a PIKA COVID-19 Vaccine in Healthy Individuals
Status: COMPLETED
Conditions: COVID-19 Pandemic
Interventions: BIOLOGICAL: PIKA COVID-19 Vaccine (CHO cell, S-protein), Arm A|BIOLOGICAL: PIKA COVID-19 Vaccine (CHO cell, S-protein), Arm B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Novel Vaccine for the Treatment of MUC1-expressing Tumor Malignancies
Status: WITHDRAWN
Conditions: Multiple Myeloma|Tumors
Interventions: BIOLOGICAL: Peptide Vaccine (MUC-1)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Efficacy and Safety of Curcuma Longa Extract Mixture on Immune Enhancement
Status: UNKNOWN
Conditions: Immunity
Interventions: DIETARY_SUPPLEMENT: Curcuma Longa Extract Mixture|DIETARY_SUPPLEMENT: placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Optimization of a Behavioral Intervention to Increase Physical Activity in Older Adults Living With HIV
Status: RECRUITING
Conditions: Hiv|Physical Inactivity|Aging
Interventions: BEHAVIORAL: Cognitive Behavioral Intervention for Physical Activity|BEHAVIORAL: Social Support for Physical Activity|BEHAVIORAL: Physical Activity Coaching|BEHAVIORAL: Brief Advice and Self-Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dalfampridine for Imbalance in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Fatigue
Interventions: DRUG: Dalfampridine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reverse King-Devick Test and History of Multiple Concussions
Status: COMPLETED
Conditions: Concussion, Mild
Interventions: DIAGNOSTIC_TEST: Conventional King-Devick test|DIAGNOSTIC_TEST: Reverse King-Devick test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Topical BX005-A in Subjects With Moderate to Severe Atopic Dermatitis
Status: UNKNOWN
Conditions: Atopic Dermatitis
Interventions: BIOLOGICAL: BX005-A|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Boceprevir in Subjects With Chronic Hepatitis C Genotype 1 Who Failed Prior Treatment With Peginterferon/Ribavirin (Study P05101AM3)(COMPLETED)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Boceprevir (SCH 503034)|BIOLOGICAL: Pegylated interferon alfa-2b (SCH 54031)|DRUG: Ribavirin (SCH 18908)|DRUG: Boceprevir placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Histological Assessment of BMAC Utilized in Sinus Lift
Status: COMPLETED
Conditions: Implant Site Reaction
Interventions: DRUG: BMAC loaded on bovine graft|DRUG: Bovine graft only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neo-RT: A Study Investigating Whether Changing the Sequence of Treatments (Starting Radiotherapy Followed by Hormone Therapy Before Surgery) is Feasible
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: RADIATION: Intensity modulated radiotherapy (IMRT)|DRUG: Endocrine therapy|PROCEDURE: Breast conserving surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Inclisiran for Subjects With ASCVD or ASCVD-Risk Equivalents and Elevated Low-density Lipoprotein Cholesterol
Status: COMPLETED
Conditions: ASCVD|Risk Factor, Cardiovascular|Elevated Cholesterol
Interventions: DRUG: Inclisiran Sodium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Iron in Patients With Cardiovascular Disease
Status: TERMINATED
Conditions: Cardiovascular Diseases|Anemia, Iron-deficiency|Acute Myocardial Infarction|Atrial Fibrillation|Systolic Heart Failure
Interventions: DRUG: Ferric carboxymaltose|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Assessment of Probiotics Product on Intestinal Health and Immune System Improvement
Status: UNKNOWN
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Probiotics fruit vegetable fiber powder product|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Follow-up Study 16-20 Years After Primary Vaccination Against Hepatitis B of Newborns From HBeAg+ & HBsAg+ Mothers
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Engerix™-B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study on Allopregnanolone and Depression in Women Across the Menopause Transition
Status: NOT_YET_RECRUITING
Conditions: Depression
Interventions: DIETARY_SUPPLEMENT: pregnenolone|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: CC-486, Lenalidomide, and Obinutuzumab for the Treatment of Recurrent or Refractory CD20 Positive B-cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Indolent B-Cell Non-Hodgkin Lymphoma|Recurrent B-Cell Non-Hodgkin Lymphoma|Recurrent Chronic Lymphocytic Leukemia|Recurrent Mucosa-Associated Lymphoid Tissue Lymphoma|Recurrent Follicular Lymphoma|Recurrent Hairy Cell Leukemia|Recurrent Lymphoplasmacytic Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Refractory B-Cell Non-Hodgkin Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Mucosa-Associated Lymphoid Tissue Lymphoma|Refractory Follicular Lymphoma|Refractory Hairy Cell Leukemia|Refractory Lymphoplasmacytic Lymphoma|Refractory Mantle Cell Lymphoma|Refractory Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Refractory Small Lymphocytic Lymphoma
Interventions: DRUG: Lenalidomide|BIOLOGICAL: Obinutuzumab|DRUG: Oral Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multiple Dose Study of Grazoprevir (MK-5172) in Hepatitis C-Infected Participants (MK-5172-010)
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Grazoprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Chemotherapy With Temodar With Topotecan for CNS Metastasis of Solid Tumors
Status: WITHDRAWN
Conditions: Central Nervous System (CNS) Metastases|Brain Metastases
Interventions: DRUG: Topotecan|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study of Changes in Disease Activity and Biomarkers With ABR-215757 in Patients With Mild Active Systemic Lupus Erythematosus (SLE)
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: paquinimod (ABR-215757)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Early Nutrition on Growth
Status: COMPLETED
Conditions: Infant Newborn
Interventions: OTHER: Human Milk|OTHER: Investigational infant formula|OTHER: Milk based standard infant formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Photopheresis With UVADEX to Prevent Graft-versus-Host Disease
Status: COMPLETED
Conditions: Graft-versus-Host Disease
Interventions: DRUG: Methoxsalen|PROCEDURE: Extracorporeal Photopheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Efficacy of Captopril Versus Propranolol and Timolol as a Treatment of Infantile Capillary Hemangioma
Status: UNKNOWN
Conditions: Infantile Hemangioma
Interventions: DRUG: oral propranolol|DRUG: Oral Captopril|DRUG: intralesional propranolol injection|DRUG: topical Timolol maleate 0.5% eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of and Immune Response to Two HIV Vaccines: SAAVI DNA-C2 Boosted With SAAVIMVA-C, in HIV-Negative Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: SAAVI DNA-C2 vaccine|BIOLOGICAL: SAAVI MVA-C vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Bovine Colostrum for Prophylaxis Against Recurrent Urinary Tract Infection in Children
Status: RECRUITING
Conditions: Urinary Tract Infections|Recurrent|Child|Prevention & Control|Infections|Urologic Diseases|Communicable Diseases
Interventions: DIETARY_SUPPLEMENT: Bovine colostrum|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Efficacy and Safety of Cholecalciferol Supplementation on the Activity of Rheumatoid Arthritis in Patients With Vitamin D Deficiency
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Vitamin D Deficiency
Interventions: OTHER: cholecalciferol versus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: p53-Adjusted Neoadjuvant Chemotherapy for Potentially Resectable Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: 5-Fluoruracil, Cisplatinum|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Effect of UHT Treated Milk on Blolipid Profile
Status: UNKNOWN
Conditions: To Investigate the Effect of UHT Treated Milk Versus Pasteurised Milk on Bloodlipid Profil
Interventions: DIETARY_SUPPLEMENT: UHT treated milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Michigan Contraceptive Access, Research, and Evaluation Study Children: Phase 1
Status: RECRUITING
Conditions: Pregnancy
Interventions: BEHAVIORAL: Mother receives voucher valued at 100% of cost of name-brand IUD (March 4, 2019-March 31, 2023)|BEHAVIORAL: Mother receives voucher valued at 50% of cost of name-brand IUD (August 26, 2018-March 3, 2019)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pain and Quality of Life After Inguinal Hernia Repair
Status: RECRUITING
Conditions: Inguinal Hernia
Interventions: PROCEDURE: Open Inguinal Hernia Repair|PROCEDURE: Laparoscopic Inguinal Hernia Repair|DEVICE: Robotic-Assisted Inguinal Hernia Repair
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Full-arch Implant-supported Frameworks From an Intraoral Scanning or From a Conventional Impression
Status: COMPLETED
Conditions: Edentulous Jaw
Interventions: DEVICE: Clinical adjustment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Gait Training for Persons With Stroke
Status: COMPLETED
Conditions: Stroke|Middle Cerebral Artery Infarction
Interventions: BEHAVIORAL: Lokomat - Physical therapy|BEHAVIORAL: Physical therapy - Lokomat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Participants With Psoriatic Arthritis Who Have an Inadequate Response to at Least One Non-Biologic Disease Modifying Anti-Rheumatic Drug (DMARD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Psoriatic Arthritis
Interventions: DRUG: Adalimumab|DRUG: Upadacitinib|DRUG: Placebo to Upadacitinib|DRUG: Placebo to Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuroprotection by Tocotrienols in Type 1 and Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetic Neuropathy|Cognitive Impairment
Interventions: DIETARY_SUPPLEMENT: Tocotrienol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression
Status: COMPLETED
Conditions: Treatment Resistant Depression
Interventions: DRUG: Psilocybin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Applying Directly Observed Therapy to Hydroxyurea to Realize Effectiveness
Status: NOT_YET_RECRUITING
Conditions: Sickle Cell Disease
Interventions: BEHAVIORAL: Video Directly Observed Therapy (VDOT)|BEHAVIORAL: Health Reminder Tip Alerts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Virtual and Augmented Reality Devices in Vestibular Physical Therapy for mTBI
Status: RECRUITING
Conditions: MTBI - Mild Traumatic Brain Injury|Dysfunction of Vestibular System
Interventions: OTHER: Conventional Therapy (CPT)|DEVICE: CAREN Therapy|DEVICE: Augmented Reality (AR) Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Deep Propioceptive Stimulation in Prader-Willi Syndrome
Status: RECRUITING
Conditions: Sleep Disorder|Hyperphagia|Behavior Disorders
Interventions: DEVICE: Deep propioceptive stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: First Rib Resection Versus Avulsion for Thoracic Outlet Syndrome
Status: RECRUITING
Conditions: Thoracic Outlet Syndrome
Interventions: PROCEDURE: first rib resection|PROCEDURE: First rib avulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Phase 2 Basket Trial With Atezolizumab and Tiragolumab in Solid Tumors
Status: RECRUITING
Conditions: Head and Neck Neoplasms|MSI-H Cancer|Melanoma
Interventions: DRUG: Tiragolumab and atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Trial
Status: RECRUITING
Conditions: Major Depressive Disorder|Suicide|Treatment Resistant Depression
Interventions: DRUG: Ketamine hydrochloride|BEHAVIORAL: i-CBT (Internet-based Cognitive Behavioural Therapy)|DRUG: Midazolam Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of Split-dose of PEG Compared With NaP Solution for Colonoscopy Preparation: A Randomized, Controlled Trial
Status: COMPLETED
Conditions: Bowel Preparation, Efficacy, Tolerability, Safety
Interventions: DRUG: Polyethylene glycol|DRUG: Sodium phosphate(NaP) solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Oxford UKA and Sigma UKA With RSA.
Status: COMPLETED
Conditions: Knee Osteoarthritis|Knee Replacement|RSA
Interventions: OTHER: Oxford UKA vs Sigma UKA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Biodegradable Versus Titanium Nailing in Forearm Shaft Fractures in Children
Status: COMPLETED
Conditions: Forearm Fracture
Interventions: DEVICE: PLGA implant, Bioretec ltd. Finland|DEVICE: Titanium elastic stable nail
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT