pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Orthopaedic Simulation of Morton's Extension to Test the Effect on Plantar Pressures of Each Metatarsal Head in Patients Without Deformity: A Pre-post-test Study.
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: OTHER: Morton extension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin B12 and Folate Administration on Homocysteine Concentrations After Nitrous Oxide Anesthesia
Status: COMPLETED
Conditions: Cardiovascular Abnormalities
Interventions: DRUG: B12-Folic Acid, nitrous oxide|DRUG: Nitrous oxide (NO) and placebo|OTHER: Placebo|OTHER: oxygen nitrogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SNaP Wound Care System Over Skin Cancer Excision Sites and Split Thickness Skin Grafts (STSGs)
Status: WITHDRAWN
Conditions: Split Thickness Skin Graft|Skin Cancer Excision Site|Skin Graft
Interventions: DEVICE: SNaP® Wound Care System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety and Tolerability of Single and Multiple Ascending Doses of HPN-01 in Healthy Subjects
Status: UNKNOWN
Conditions: Non-Alcoholic Steatohepatitis (NASH)
Interventions: DRUG: HPN-01|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hip Strengthening Versus Quadriceps Based Training for Patellofemoral Pain Syndrome
Status: UNKNOWN
Conditions: Patellofemoral Pain Syndrome
Interventions: OTHER: Isolated hip strengthening|OTHER: Quadriceps based training|OTHER: Active control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diindolylmethane in Preventing Cancer in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy, no Evidence of Disease
Interventions: DRUG: diindolylmethane|OTHER: placebo|OTHER: pharmacological study|OTHER: laboratory biomarker analysis|OTHER: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase I Trial to Investigate the Safety and Tolerability of PF-06649751
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06649751|DRUG: PF-06649751
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Non-Interventional Open Label Prospective Observational Comparative Study On Evaluation Of Compliance Of The Empiric Treatment With Azithromycin SR Versus Amoxiclav 1000 Mg In Adult Patients With Mild To Moderate Community Acquired Pneumonia
Status: TERMINATED
Conditions: Community-Acquired Pneumonia
Interventions: DRUG: Azithromycin SR|DRUG: Amoxiclav
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison Between Asynchronous Online Care Model With Usual In Office Care for the Management of Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: OTHER: Online Teledermatology Care|OTHER: Conventional in Office Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Ceftaroline Pharmacokinetics in Continuous Renal Replacement Therapy
Status: COMPLETED
Conditions: Infection During Renal Replacement Therapy|Critically Ill
Interventions: OTHER: Ceftaroline levels in CRRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial of HRS-7450 in Chinese Healthy Volunteers
Status: NOT_YET_RECRUITING
Conditions: Cerebral Stroke
Interventions: DRUG: HRS-7450 ；Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sedation of Morbidly Obese for Balloon Insertion
Status: UNKNOWN
Conditions: Morbid Obesity
Interventions: DRUG: Fentanyl|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ADI-PEG 20 or Placebo Plus Gem and Doc in Previously Treated Subjects With Leiomyosarcoma (ARGSARC)
Status: RECRUITING
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: ADI PEG20|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Liquid Volume and the Amount of Incorporated Gas Into a Carbohydrate/Protein Beverage on Satiety
Status: COMPLETED
Conditions: Satiety|Appetite
Interventions: DIETARY_SUPPLEMENT: Beverage 1|DIETARY_SUPPLEMENT: Beverage 2|DIETARY_SUPPLEMENT: Beverage 3|DIETARY_SUPPLEMENT: Beverage 4|DIETARY_SUPPLEMENT: Beverage 5|DIETARY_SUPPLEMENT: Beverage 6|DIETARY_SUPPLEMENT: Beverage 7|DIETARY_SUPPLEMENT: Beverage 8|DIETARY_SUPPLEMENT: Beverage 9
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Traditional vs. Graft-augmented Posterior Colporrhaphy
Status: TERMINATED
Conditions: Pelvic Organ Prolapse|Posterior Vaginal Wall Defects
Interventions: PROCEDURE: Graft-augmented colporrhaphy|PROCEDURE: Traditional posterior colporrhaphy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Immunogenicity of SARS-CoV-2 Variant (COVID-19 Omicron) mRNA Vaccine (Phase 1)
Status: UNKNOWN
Conditions: COVID-19
Interventions: BIOLOGICAL: ABO1009-DP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Gum Chewing on Postoperative Ileus
Status: WITHDRAWN
Conditions: Perforated Appendicitis
Interventions: DEVICE: Motion sickness wristband|DIETARY_SUPPLEMENT: Chewing Gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 2 Study of Ruxolitinib With Chemotherapy in Children With Acute Lymphoblastic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukemia
Interventions: DRUG: Ruxolitinib|DRUG: Asparaginase Erwinia Chrysanthemi|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Dexamethasone|DRUG: Doxorubicin|DRUG: Leucovorin Calcium|DRUG: Mercaptopurine|DRUG: Methotrexate|DRUG: Pegaspargase|DRUG: Prednisone|DRUG: Thioguanine|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cosmetic Appeal, HRQoL and Effectiveness of Simple and Pseudotesticular Techniques of Orchidectomy in Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer|Quality of Life|Orchiectomy
Interventions: PROCEDURE: Bilateral simple orchidectomy (BSO)|PROCEDURE: Bilateral Subcapsular Orchidectomy|PROCEDURE: Bilateral Epididymal-sparing Orchidectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Body Awareness Therapy and Biomarkers in Fibromyalgia
Status: RECRUITING
Conditions: Fibromyalgia
Interventions: OTHER: Basic Body Awareness Therapy|OTHER: Stretching Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple Dose Study of Blockade of Opioid Effects by Injections of Buprenorphine in Participants With Opioid Disorder
Status: COMPLETED
Conditions: Opioid Use Disorder
Interventions: DRUG: Buprenorphine|DRUG: buprenorphine and naloxone|DRUG: hydromorphone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effects of ACT-541468 on Nighttime Respiratory Function in Patients With Mild to Moderate Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: ACT-541468|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HRQoL in Overweight and Obese Children/Adolescents
Status: UNKNOWN
Conditions: Obesity, Childhood|Health Related Quality of Life|Intervention Program|Obesity, Adolescent|Overweight and Obesity
Interventions: BEHAVIORAL: multi-professional group programme 'kinderleicht'
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-World Study on Adjuvant Therapy Combined With Shenlingcao Oral Liquid in Patients for Stage II and IIIA Non-small Cell Lung Cancer After Radical Resection
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung|Chemotherapy, Adjuvant
Interventions: DRUG: Shenlingcao Oral Liquid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ticagrelor and Clopidogrel on Platelet Effects in Chinese Patients With Stable Coronary Artery Disease
Status: COMPLETED
Conditions: Platelet Reactivity
Interventions: DRUG: Ticagrelor 90mg|DRUG: Clopidogrel 75mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Tripterygium Capsule to Treat Early Ankylosing Spondylitis
Status: UNKNOWN
Conditions: Early Ankylosing Spondylitis
Interventions: DRUG: Tripterygium|DRUG: Sulfasalazine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pulse Reduction On Beta-blocker and Ivabradine Therapy
Status: COMPLETED
Conditions: Dilated Cardiomyopathies, Idiopathic|Heart Failure, Systolic|Ventricular Remodeling|Electrical Remodeling
Interventions: DRUG: Ivabradine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of EDP1066 in Healthy Participants and Participants With Mild to Moderate Psoriasis and Atopic Dermatitis
Status: COMPLETED
Conditions: Psoriasis|Atopic Dermatitis
Interventions: OTHER: EDP1066|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Iwankapiya-Healing: Historical Trauma Practice and Group IPT for American Indians
Status: COMPLETED
Conditions: Depression|Grief|PTSD|Interpersonal Relations
Interventions: BEHAVIORAL: HTUG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability, Safety and Immunogenicity Trial of the Flu-M® Inactivated Vaccine in Volunteers Aged 18 to 60 Years
Status: COMPLETED
Conditions: Influenza|Flu, Human
Interventions: BIOLOGICAL: Flu-M [inactivated split influenza vaccine] without preservative|BIOLOGICAL: Flu-M [inactivated split influenza vaccine] with preservative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Pivotal Bioequivalence Study of DOXIL/CAELYX (Doxorubicin HCL) in Patients With Advanced or Refractory Solid Malignancies Including Patients With Ovarian Cancer
Status: COMPLETED
Conditions: Neoplasms|Neoplasms, Ovarian|Neoplasms, Breast|Advanced or Refractory Solid Malignancies
Interventions: DRUG: DOXIL/CAELYX (doxorubicin) Treatment Sequence AB|DRUG: DOXIL/CAELYX (doxorubicin) Treatment Sequence BA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clofarabine and Gemtuzumab in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: clofarabine|DRUG: gemtuzumab ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi Laser Platform Comparison Study for LASIK
Status: UNKNOWN
Conditions: Myopia|Astigmatism
Interventions: DEVICE: Excimer Lasers|DEVICE: Excimer Laser for the LASIK procedure|DEVICE: Excimer Laser for LASIK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bupropion Hydrochloride in Improving Sexual Desire in Women With Breast or Gynecologic Cancer
Status: COMPLETED
Conditions: Breast Carcinoma|Cervical Carcinoma|Ovarian Carcinoma|Postmenopausal|Uterine Corpus Cancer|Vaginal Carcinoma|Vulvar Carcinoma
Interventions: DRUG: Bupropion 150 mg XL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ultrasonic Scaler VS Erythritol for Peri-implant Maintenance of Loaded Implants With Crowns Made by Different Materials
Status: NOT_YET_RECRUITING
Conditions: Peri-implant Mucositis
Interventions: OTHER: Erythritol prophylactic powders|OTHER: Ultrasonic scaler with peek inserts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise-induced Hypoalgesia and Proprioceptive Changes, Comparing Isometric to Isotonic Neck Exercises
Status: NOT_YET_RECRUITING
Conditions: Exercise
Interventions: PROCEDURE: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comfort Theory-Based Nursing Interventions in Women With Stress Urinary Incontinence
Status: RECRUITING
Conditions: Urinary Incontinence
Interventions: BEHAVIORAL: Nursing Practices Based on Kolcaba's Comfort Theory
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hypoxia and Inflammatory Injury in Human Renovascular Hypertension
Status: COMPLETED
Conditions: Renal Artery Stenosis|Ischemic Nephropathy|Renovascular Disease|Chronic Kidney Disease
Interventions: DRUG: Mesenchymal stem cell|PROCEDURE: Mesenchymal stem cell delivery with stent placement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thrust Versus Non-thrust Manipulation in Chronic Low Back Pain
Status: TERMINATED
Conditions: Low Back Pain|Mechanical Low Back Pain|Backache
Interventions: OTHER: Thrust Manipulation|OTHER: Non-thrust manipulation (NTM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate Efficacy of GR-MD-02 for Treatment of Liver Fibrosis in Patients With NASH With Advanced Fibrosis
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis
Interventions: DRUG: GR-MD-02|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Tapering Pace and Selected Traits on Hypnotic Discontinuation
Status: COMPLETED
Conditions: Hypnotic Dependence Among Those With Insomnia
Interventions: DRUG: 0% Hypnotic Medication Taper|DRUG: 25% Hypnotic Medication Taper|DRUG: 10% Hypnotic Medication Taper
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of tDCS on the Brain Activation Measured During the Decision Not to Smoke in High-risk Situations
Status: UNKNOWN
Conditions: Tobacco Use Disorder
Interventions: DEVICE: active transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Implementation of a Multimodal Prehabilitation Program in Robotic Oncological Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer|Gynecologic Cancer
Interventions: BEHAVIORAL: Prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Nutritional Counseling Associated With Transcranial Direct-current Stimulation in Binge Eating Reduction
Status: ACTIVE_NOT_RECRUITING
Conditions: Transcranial Direct Current Stimulation|Binge-Eating Disorder|Cognitive Behavioral Therapy
Interventions: DEVICE: a-tDCS|BEHAVIORAL: Nutritional Counseling|COMBINATION_PRODUCT: a-tDCS and nutritional counseling|COMBINATION_PRODUCT: s-tDCS and nutritional counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies
Status: RECRUITING
Conditions: Cholangiocarcinoma|Gallbladder Carcinoma|Stage III Gallbladder Cancer AJCC v8|Stage III Hilar Cholangiocarcinoma AJCC v8|Stage III Intrahepatic Cholangiocarcinoma AJCC v8|Stage IV Gallbladder Cancer AJCC v8|Stage IV Hilar Cholangiocarcinoma AJCC v8|Stage IV Intrahepatic Cholangiocarcinoma AJCC v8
Interventions: DRUG: Avelumab|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|RADIATION: Hypofractionated Radiation Therapy|DRUG: Peposertib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of 0.003% AR-15512 on Subjects With Dry Eye Disease
Status: NOT_YET_RECRUITING
Conditions: Dry Eye Disease
Interventions: DRUG: 0.003% AR-15512|OTHER: Artificial Tears
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treating the Endothelium to Restore Insulin Sensitivity
Status: COMPLETED
Conditions: Obesity|Insulin Resistance|Impaired Glucose Tolerance|Pre-diabetes
Interventions: DRUG: Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of CV301 in Combination With Anti-PD-1 Therapy in Subjects With Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: BIOLOGICAL: CV301|BIOLOGICAL: Pembrolizumab|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Rikkunshito on Gastric Accommodation and Nutrient Volume Tolerance in Functional Dyspepsia
Status: COMPLETED
Conditions: Dyspepsia
Interventions: DRUG: Rikkunshito|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of AMG510 in Stage III Unresectable NSCLC KRAS p.G12C Patients and Ineligible for Chemo-radiotherapy
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer Stage III|KRAS P.G12C
Interventions: DRUG: Sotorasib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Training for Social Skills in Schizophrenia - Comparison With Cognitive Training
Status: RECRUITING
Conditions: Schizophrenia|Schizo Affective Disorder|Social Skills
Interventions: BEHAVIORAL: VR social skills training|BEHAVIORAL: Cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of SP-103 in Subjects With Moderate to Severe Acute Lower Back Pain
Status: COMPLETED
Conditions: Moderate to Severe Acute Lower Back Pain
Interventions: DRUG: SP-103|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation of Long-acting Cabotegravir + Rilpivirine Administration Out of "HIV Units".
Status: NOT_YET_RECRUITING
Conditions: HIV Infections
Interventions: OTHER: DAY HOSPITAL ARM|OTHER: Specialist-Care arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety & Efficacy Study of HTU-520 in the Treatment of Distal Subungual Onychomycosis of the Toenail
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DRUG: HTU-520 Patch|OTHER: Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Deliberate Hypotension on QTc, Tp-e Intervals and Heart Rate Variability
Status: COMPLETED
Conditions: Mandibular Prognathism|Mandibular Retrognathism
Interventions: DRUG: Group R|DRUG: Group N|DRUG: Group D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Facial Gingival Level Evaluation Following Soft Tissue Augmentation Using CTG Around Immediate Dental Implants vs Immediate Dental Implants Alone in the Esthetic Zone.
Status: COMPLETED
Conditions: Immediate Dental Implants Connective Tissue Graft Esthetic Zone
Interventions: PROCEDURE: Intervention group:(Group B) connective tissue graft combined with immediate implant.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Cognitive Training for Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: DEVICE: Virtual Reality Cognitive Training|BEHAVIORAL: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Exercise on Serum BDNF and Irisin Levels in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Sleep Quality|Aerobic Exercise
Interventions: DEVICE: Aerobic and home exercise|OTHER: Home exercise|OTHER: Healthy control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effect of Topical Testosterone Replacement Therapy on Blood Pressure in Adult Male Participants With Hypogonadism
Status: COMPLETED
Conditions: Hypogonadism
Interventions: DRUG: AndroGel 1.62%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Visceral Manual Therapy in Bruxist Patients With Gastroesophageal Reflux
Status: RECRUITING
Conditions: Bruxism|Gastroesophageal Reflux
Interventions: PROCEDURE: Visceral manual treatment|PROCEDURE: Respiratory listening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Camrelizumab Plus Apatinib as Consolidation Therapy in Non-Small Cell Lung Cancer Patients Treated With Chemoradiotherapy
Status: RECRUITING
Conditions: Locally Advanced Non-Small Cell Lung Cancer
Interventions: DRUG: Camrelizumab, PD-1 monoclonal antibody|DRUG: Apatinib, VEGFR2 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of PIPAC and Minimally Invasive Radical Resection in High-risk Gastric Cancer Patients.
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer|Chemotherapy, Adjuvant|Peritoneal Metastases|Minimally Invasive Surgical Procedures
Interventions: DRUG: Cisplatin|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Locally Delivered Morus Alba Gel on Moderate Periodontitis
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: OTHER: Chlorhexidine gel|OTHER: Morus alba gel|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-center, Randomized, Double-blind, Phase III Clinical Trial of Leucogen Versus Placebo on Leukocyte and Platelet Whole-course Management Assisted by PFLL Chemotherapy in the Treatment of Stage IV, Recurrent or Metastatic NPC
Status: NOT_YET_RECRUITING
Conditions: Nasopharyngeal Carcinoma|Leucogen|Chemotherapy|Myelosuppression
Interventions: DRUG: 5-fu|DRUG: Lobaplatin|DRUG: Placebo|DRUG: leucogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Thorough QT Study of Intravenous Amisulpride
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: APD421 5 mg|DRUG: APD421 40 mg|DRUG: Moxifloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Carbohydrate Loading on Gastric Residual Volume and Hunger Score
Status: UNKNOWN
Conditions: Gastric Residual Volume
Interventions: DIETARY_SUPPLEMENT: resource|OTHER: plain water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Prevalence of Major Psychiatric Disorders in a Cohort of Women With Clinical Criteria Corresponding to Pure, Abortive-form, Obstetrical, Antiphospholipid Syndrome
Status: COMPLETED
Conditions: Antiphospholipid Syndrome|Factor V Leiden Thrombophilia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Action Observation Based Rehabilitation of Children With Unilateral Cerebral Palsy
Status: COMPLETED
Conditions: Hemiplegic Cerebral Palsy|Motor Activity
Interventions: OTHER: AOT Pathological Model Experimental Group|OTHER: AOT Healthy Model Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cervical Ripening Before Induction of Labour at Term: a Randomised Comparison of Prostin vs Propess
Status: COMPLETED
Conditions: Cervical Ripening|Labor, Induced
Interventions: DRUG: Prostaglandin E2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety of K-755 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: K-755 Part A (SAD)|DRUG: Placebo Part A (SAD)|DRUG: K-755 Part B (MAD)|DRUG: Placebo Part B (MAD)|DRUG: K-755 Part C (FE)|DRUG: K-755 Part D (FE)|DRUG: K-755 Part E (MAD)|DRUG: Placebo Part E (MAD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Vaginal Antimicrobacterial Preparation Before Cesarean Secation for Endometritis Prevention
Status: UNKNOWN
Conditions: A Known Allergy to Antiseptic Soap|Women Who Had Any Infection in the Perioperative Period|A Known Allergy to Chlorohexidine Alcohol or Shellfis
Interventions: OTHER: vaginal preparation before CS with Septal soap and septol.|OTHER: No vaginal preparation before CS with Septal soap and septol.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Chemoradiotherapy Versus Neoadjuvant Chemotherapy For Unresectable Locally Advanced Colon Cancer
Status: TERMINATED
Conditions: Colon Cancer
Interventions: RADIATION: Radiotherapy|DRUG: oxaliplatin+capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methotrexate and Temozolomide Versus Methotrexate, Procarbazine, Vincristine and Cytarabine
Status: UNKNOWN
Conditions: Lymphoma
Interventions: DRUG: Methotrexate and temozolomide|DRUG: Methotrexate , procarbazine ,vincristine ,cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy & Safety of Clindamycin and Tretinoin in Acne
Status: UNKNOWN
Conditions: Acne
Interventions: DRUG: Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Advanced Invasive Diagnosis for Patients With Chronic Coronary Syndromes Undergoing Coronary ANGIOgraphy (AID-ANGIO)
Status: RECRUITING
Conditions: Chronic Coronary Syndrome|Coronary Artery Disease|Microvascular Angina|Coronary Vasospasm|Myocardial Ischemia
Interventions: DIAGNOSTIC_TEST: AID strategy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: BOTOX® in the Treatment of Upper Facial Lines in Japan
Status: COMPLETED
Conditions: Upper Facial Rhytides|Crow's Feet Lines|Glabellar Lines|Frown Lines
Interventions: BIOLOGICAL: botulinum toxin Type A (44U)|BIOLOGICAL: botulinum toxin Type A (32U)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Ataluren (PTC124) in Nonambulatory Participants With Nonsense-Mutation-Mediated Duchenne/Becker Muscular Dystrophy (nmDMD/BMD)
Status: TERMINATED
Conditions: Duchenne Muscular Dystrophy|Becker Muscular Dystrophy
Interventions: DRUG: Ataluren|DRUG: Chronic Corticosteroid Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tai Chi or Hydrotherapy for People With Osteoarthritis of the Hip(s) or Knee(s)
Status: UNKNOWN
Conditions: Osteoarthritis, Hip|Osteoarthritis, Knee
Interventions: BEHAVIORAL: Tai Chi classes|BEHAVIORAL: Hydrotherapy classes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of Migalastat in Pediatric Subjects (Aged 12 to <18 Years)
Status: COMPLETED
Conditions: Fabry Disease
Interventions: DRUG: Migalastat HCl 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of BIC/F/TAF Versus Standard of Care in the Treatment of New HIV Infection Diagnoses in the Context of 'Test and Treat'
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: Biktarvy|DRUG: Symtuza
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Apatinib Combined With Second - Line Chemotherapy for Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Neoplasms
Interventions: DRUG: Apatinib|DRUG: standard second-line chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture and Post-Surgical Wound Healing
Status: TERMINATED
Conditions: Postoperative Complications|Surgical Wound Infection|Surgical Wound Dehiscence
Interventions: OTHER: acupuncture|OTHER: sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Beans and Oats Snack Bar on Hypertriglyceridemic Women
Status: COMPLETED
Conditions: Hypertriglyceridemia|Obesity
Interventions: DIETARY_SUPPLEMENT: BOSB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Survival Benefit of Compound Kushen Injection in the Treatment of Advanced Colorectal Cancer
Status: RECRUITING
Conditions: Advanced Colorectal Carcinoma
Interventions: DRUG: palliative care group first-line scheme+compound kushen injection|DRUG: palliative care group first-line scheme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Actions in the Body of Healthy Subjects of Three Modified Release Formulations of YM178 Under Fasted and Fed Conditions With One Immediate Release Formulation of YM178 Under Fasted Conditions
Status: COMPLETED
Conditions: Pharmacokinetics of YM178|Healthy Subjects
Interventions: DRUG: YM178 modified release (OCAS)|DRUG: YM178 immediate release (IR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: DDBT Adapted Problem Solving Treatment for Primary Care
Status: COMPLETED
Conditions: Depression|PTSD
Interventions: BEHAVIORAL: Usual Care|BEHAVIORAL: Modified Behavioral Activation (Task Sharing)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Trial Based on the Use of Mesenchymal Stem Cells From Autologous Bone Marrow in Patients With Lumbar Intervertebral Degenerative Disc Disease
Status: COMPLETED
Conditions: Intervertebral Disc Disease
Interventions: PROCEDURE: Instrumented posterolateral arthrodesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women (Replicate Study)
Status: COMPLETED
Conditions: Uterine Fibroids|Heavy Menstrual Bleeding
Interventions: DRUG: Elagolix|DRUG: Placebo for Estradiol/Norethindrone Acetate|DRUG: Estradiol/Norethindrone Acetate|DRUG: Placebo for Elagolix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Immune Response to Env-C DNA and Protein Vaccines in Kenya
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: Env-C Plasmid DNA|BIOLOGICAL: HIV Env gp145 C.6980 protein|DRUG: Rehydragel®|BIOLOGICAL: ALF43|BIOLOGICAL: dmLT|DRUG: Placebo (IM)|DRUG: Placebo (TCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: DyeVert™ System for Contrast Monitoring in At-Risk Patients Undergoing Angiography: A Real-World Registry
Status: UNKNOWN
Conditions: Patients at Risk for Developing Contrast-induced Nephropathy
Interventions: DEVICE: DyeVert™ Contrast Reduction Systems
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Acid Base Balance of ICU Patients With Severe Hypoalbuminemia, Before and After an Albumin Infusion, Using Stewart Approach
Status: UNKNOWN
Conditions: Hypoalbuminemia|Adult ICU Patient|Stewart Approach for Acid Base Disorders|Human Albumin Perfusion
Interventions: OTHER: stewart approach
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Role of a Dietary Supplement in Lowering SAH in Healthy Adults With Elevated Plasma SAH and Normal Homocysteine Levels
Status: COMPLETED
Conditions: Elevated S-adenosylhomocysteine
Interventions: DIETARY_SUPPLEMENT: Alpha-GPC, Creatine and Ashwagandha (Sensoril®)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ca-hydroxyapatite, Fluoroapatite, and Mg-Zn-hydroxyapatite for Dentin Hypersensitivity Management
Status: COMPLETED
Conditions: Dentin Hypersensitivity
Interventions: COMBINATION_PRODUCT: Hygienic procedure (toothbrushing using HAP-containing toothpaste)|COMBINATION_PRODUCT: Hygienic procedure (toothbrushing using Zn Mg HAP-containing)|COMBINATION_PRODUCT: Hygienic procedure (toothbrushing using FAP-containing toothpaste)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 34mm Cuff Study for Endovascular Repair of Abdominal Aortic Aneurysms
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: DEVICE: Endologix Powerlink 34 mm stent graft cuff
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of GSK1278863 to Reduce Ischemic Events in Patients Undergoing Thoracic Aortic Aneurysm Repair
Status: COMPLETED
Conditions: Surgical Procedures
Interventions: DRUG: GSK1278863|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Double-Blind Study in Healthy Volunteers to Assess the Effect of E7080 on the QTc Interval
Status: COMPLETED
Conditions: Refractory Solid Tumors|Lymphomas
Interventions: DRUG: Lenvatinib|DRUG: Moxifloxacin 400 mg|DRUG: Placebos (matched to 4 mg and 10 mg lenvatinib capsules).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cognitive Remediation for Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: computer-assisted cognitive remediation (CACR)|BEHAVIORAL: manualized computer control condition (RC).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Serrantor OCT Study
Status: NOT_YET_RECRUITING
Conditions: Critical Limb Ischemia
Interventions: DEVICE: Serranator PTA Serration Catheter|DRUG: PTA (Standard of Care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AXL Inhibitor BGB324 in Treating Participants With Recurrent Glioblastoma Undergoing Surgery
Status: TERMINATED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: BGB 324 (before surgery)|DRUG: BGB 324 (after surgery)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coronary Artery Bypass Surgery (CABG) Off or On Pump Revascularization Study
Status: COMPLETED
Conditions: the Efficacy and Safety of Off-pump CABG
Interventions: PROCEDURE: Coronary Artery Bypass Graft with the use of CPB|PROCEDURE: Coronary Artery Bypass Graft without the use of CPB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Thoracic Paravertebral Block and Pectoral Nerve Block
Status: COMPLETED
Conditions: Thoracic Paravertebral Block|Video-assisted Thoracoscopic Surgery|Postoperative Analgesia
Interventions: PROCEDURE: paravertebral block|PROCEDURE: pectoral block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prevention of Metabolic Complications of Glucocorticoid Excess
Status: COMPLETED
Conditions: Iatrogenic Cushing Disease
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vestibulopathy, Imbalance, and Gait Disturbances in Parkinson Disease
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: Non invasive neuromodulation device pattern 1|DEVICE: Non invasive neuromodulation device pattern 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ledipasvir/Sofosbuvir Fixed-Dose Combination With Ribavirin or GS-9669 in Subjects With Chronic Genotype 1 HCV Infection
Status: COMPLETED
Conditions: Chronic HCV Infection
Interventions: DRUG: LDV/SOF|DRUG: RBV|DRUG: GS-9669
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Rehabilitation and Galantamine for Post Stroke Cognitive Impairment
Status: COMPLETED
Conditions: Stroke|Cognitive Impairment
Interventions: DRUG: Galantamine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab (MK-3475) Plus Epacadostat vs Standard of Care in mRCC (KEYNOTE-679/ECHO-302)
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma (RCC)
Interventions: DRUG: Pembrolizumab|DRUG: Epacadostat|DRUG: Sunitinib|DRUG: Pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Treatment of Dry Eye With Intracanalicular Dexamethasone, Restasis, and/or Lotemax
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Cyclosporine|DRUG: Loteprednol Etabonate|DRUG: Dexamethasone Ophthalmic 0.4 Mg Ophthalmic Insert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double Blind Combination of Rituximab by Intravenous and Intrathecal Injection Versus Placebo in Patients With Low-Inflammatory Secondary Progressive Multiple Sclerosis (RIVITaLISe)
Status: TERMINATED
Conditions: Multiple Sclerosis
Interventions: DRUG: Rituximab|OTHER: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Retrospective, External Comparator Study of Lazertinib as the 2nd-Line Treatment in Patients With EGFR Mutation+ NSCLC
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Lazertinib|DRUG: Platinum-based Chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: AMS INSIGHT 1 Study - Bioabsorbable Metal Stent Investigation in Chronic Limb Ischemia Treatment
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: DEVICE: MAGIC EXPLORER (Biotronik AG)|DEVICE: PLEON EXPLORER (Biotronik AG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2, Placebo-Controlled Study To Evaluate The Efficacy And Safety Of PF-00489791 In Patients With Type 2 Diabetes And Overt Nephropathy
Status: COMPLETED
Conditions: Diabetic Nephropathies
Interventions: DRUG: PF-00489791|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Atezolizumab Plus Tivozanib in Immunologically Cold Tumor Types
Status: RECRUITING
Conditions: Bile Duct Cancer|Gall Bladder Cancer|Breast Cancer|Neuroendocrine Tumors|Ovarian Cancer|Pancreatic Adenocarcinoma|Soft Tissue Sarcoma|Vulvar Cancer|Prostate Cancer
Interventions: DRUG: Atezolizumab|DRUG: Tivozanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SHR-A1811 for Subjects With Her2-positive Gastric Cancer and Gastroesophageal Junction Adenocarcinoma After Progression on or After First-line Anti-HER2 Therapy-containing Regimen
Status: RECRUITING
Conditions: HER2-positive Advanced Gastric Cancer or Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: SHR-A1811|DRUG: Ramucirumab / Paclitaxel/ Docetaxel/ Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Odontoid Fracture Study Treated With Pulsed Electromagnetic Fields
Status: TERMINATED
Conditions: Odontoid Fracture Type II
Interventions: DEVICE: Pulsed Electromagnetic Feld (PEMF) Orthofix Cervical-Stim Model 2205OD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Combined of Lantus(Insulin Glargine) and Lyxumia (Lixisenatide) on Insulin Secretion and Gastric Emptying
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Luyxumia versus Lantus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: