pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase 3 Booster Vaccination Against COVID-19
Status: COMPLETED
Conditions: COVID-19|Sars-CoV-2 Infection
Interventions: BIOLOGICAL: CoronaVac|BIOLOGICAL: Turkovac
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ilomedin Treatment for Patients Having Undergone Primary Percutaneous Coronary Intervention (PCI)
Status: COMPLETED
Conditions: Myocardial Infarct
Interventions: DRUG: Ilomedin|DRUG: Placebo|DRUG: Ilomedin|DRUG: Ilomedin and standard low dose treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Bevacizumab Plus XELOX/XELIRI for First-line Treatment in Unresectable Advanced Colorectal Cancer
Status: UNKNOWN
Conditions: Advanced Colorectal Cancer
Interventions: DRUG: Bevacizumab、Oxaliplatin、Irinotecan、Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Mirvetuximab Soravtansine vs. Investigator's Choice of Chemotherapy in Women With Folate Receptor (FR) Alpha Positive Advanced Epithelial Ovarian Cancer (EOC), Primary Peritoneal or Fallopian Tube Cancer
Status: COMPLETED
Conditions: Epithelial Ovarian Cancer|Primary Peritoneal Carcinoma|Fallopian Tube Cancer|Ovarian Cancer
Interventions: DRUG: Mirvetuximab soravtansine|DRUG: Paclitaxel|DRUG: Pegylated liposomal doxorubicin|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Embodied Virtual Reality Therapy for Functional Neurological Symptom/ Conversion Disorder
Status: TERMINATED
Conditions: Conversion Disorder|Psychogenic Movement Disorder|Functional Movement Disorder|Functional Neurological Disorder|Non-epileptic Seizures
Interventions: OTHER: Embodied Virtual Reality Therapy|OTHER: Virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trial of Low-Dose Methotrexate and I 131 Tositumomab for Previously Untreated, Advanced-Stage, Follicular Lymphoma
Status: TERMINATED
Conditions: Follicular Lymphoma
Interventions: DRUG: Bexxar|DRUG: Low Dose Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-doses Melphalan Inhalation in Patients With COVID-19 (CoronavIrus Disease 2019) Pneumonia
Status: UNKNOWN
Conditions: COVID-19|Viral Pneumonia
Interventions: DRUG: Melphalan|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant JS001, or JS001 in Combination With Pemetrexed and Carboplatin in Resectable NSCLC.
Status: SUSPENDED
Conditions: Efficacy and Safety
Interventions: DRUG: JS001|DRUG: Pemetrexed|DRUG: Carboplatin|PROCEDURE: Thoracic Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab, Ixabepilone, and Carboplatin in Treating Patients With HER2/Neu-Positive Metastatic Breast Cancer
Status: COMPLETED
Conditions: HER2-positive Breast Cancer|Male Breast Cancer|Recurrent Breast Cancer|Stage IV Breast Cancer
Interventions: BIOLOGICAL: trastuzumab|DRUG: ixabepilone|DRUG: carboplatin|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Double Blind Cross Over Study for Nabilone in Spasticity in Spinal Cord Injury Persons
Status: COMPLETED
Conditions: Spasticity in Spinal Cord Injured Persons
Interventions: DRUG: nabilone then placebo|DRUG: placebo then nabilone
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Amlodipine on Blood Flow of Preovulatory Follicle in Polycystic Ovarian Patients
Status: COMPLETED
Conditions: Female Infertility Associated With Anovulation
Interventions: DRUG: Clomifene citrate ( clomid 50 mg )|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Intramyocardial Injection of Ventrix Bio Extracellular Matrix (VentriGel) to Assess the Safety and Feasibility in Pediatric Patients With Hypoplastic Left Heart Syndrome (HLHS)
Status: NOT_YET_RECRUITING
Conditions: Hypoplastic Left Heart Syndrome
Interventions: DRUG: Ventrix Bio Extracellular Matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calcitriol and Carboplatin in Treating Patients With Stage IV Prostate Cancer That Has Not Responded to Hormone Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: calcitriol|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quality of Life Interventions During Cervical Cancer Treatment
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: BEHAVIORAL: Relaxation training|BEHAVIORAL: Therapeutic touch|OTHER: Questionnaire administration|OTHER: Ancillary studies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate Effect of Itraconazole on the Pharmacokinetics of Cobimetinib in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Cobimetinib|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Comparative Antimicrobial Efficacy of Two Topical Acne Therapies for the Treatment of Facial Acne
Status: COMPLETED
Conditions: Acne
Interventions: DRUG: Duac|DRUG: Ziana gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of a Gene Transfer Vector (Rh.10) for Children With Late Infantile Neuronal Ceroid Lipofuscinosis (LINCL)
Status: COMPLETED
Conditions: Batten Disease|Late-Infantile Neuronal Ceroid Lipofuscinosis
Interventions: BIOLOGICAL: AAVrh.10CUhCLN2 vector 9.0x10^11 genome copies|BIOLOGICAL: AAVrh.10CUhCLN2 vector 2.85x10^11 genome copies
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Skin Barrier Dysfunction in Infants at High Risk of Atopy
Status: WITHDRAWN
Conditions: Atopic Dermatitis|Eczema|Food Allergy
Interventions: OTHER: Evaluating atopy in infants|OTHER: Evaluating TEWL and STS in adults
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bortezomib With or Without Hormone Therapy in Treating Patients With Relapsed Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Velcade|DRUG: LH-RH Agonist|DRUG: Androgen Receptor Antagonists
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Vitality Dietary Supplement on Physical and Mental Function in Middle-aged Adults
Status: COMPLETED
Conditions: Health-related Quality of Life
Interventions: DIETARY_SUPPLEMENT: Vitality Product|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Comparison of the Physiological and Behavioral Effects of Suvorexant and Zolpidem in Healthy Volunteers: A Randomized, Double-blind, Placebo Controlled Study
Status: ENROLLING_BY_INVITATION
Conditions: Performance Enhancing Product Use
Interventions: DRUG: Suvorexant 10 mg|DRUG: Zolpidem|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Clinical Outcomes Among Non-valvular Atrial Fibrillation Patients With Renal Dysfunction
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)|DRUG: Warfarin sodium
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Polyphenols Supplementation on Cycling Endurance
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Vinitrox polyphenols|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Near-Infrared Fluorescence Imaging With ICG During Reconstructive Gynecologic Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Gynecologic Surgery
Interventions: DIAGNOSTIC_TEST: ICG-NIR angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Organization Program of DiabEtes INsulIN ManaGement
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Structured Education|BEHAVIORAL: Conventional Diabetes Education|DRUG: Scilin®M30
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Prequirurgic Instrument to Decrease Anxiety in Urogical Quirurgic Patients: a Randomized Clinical Trial
Status: COMPLETED
Conditions: Anxiety|Nurse-Patient Relations|Behavior
Interventions: OTHER: Guide of hosting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Belrestotug Plus Dostarlimab Compared With Placebo Plus Pembrolizumab in Previously Untreated Participants With Programmed Death Ligand 1 (PD-L1) High Non-small-cell Lung Cancer (NSCLC)
Status: RECRUITING
Conditions: Lung Cancer, Non-Small Cell
Interventions: BIOLOGICAL: Dostarlimab|BIOLOGICAL: Belrestotug|BIOLOGICAL: Pembrolizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Airway Stents for Excessive Dynamic Airway Collapse
Status: ENROLLING_BY_INVITATION
Conditions: Tracheobronchomalacia|Excessive Dynamic Airway Collapse
Interventions: PROCEDURE: Dynamic Flexible Bronchoscopy|PROCEDURE: Rigid Bronchoscopy|DEVICE: Stent placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Singe Dose Study of PF- 06946860 in Healthy Adult Japanese Participants
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: PF-06946860|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bioavailability of EPA + DHA in a SMEDS Formulation
Status: COMPLETED
Conditions: Bioavailability
Interventions: DIETARY_SUPPLEMENT: EPA + DHA in SMEDS Formulation|OTHER: Lovaza (active comparator; already FDA approved)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Intrathoracic Pressure Regulation on Decreased Cerebral Perfusion
Status: TERMINATED
Conditions: Head Injury|Intracranial Pathology|Compromised Cerebral Perfusion
Interventions: DEVICE: ITPR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Tofacitinib vs Abatacept
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tofacitinib|DRUG: Abatacept
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Intravenous Iron Therapy and Erythropoiesis-stimulation Agent Combination on Renal Transplant Outcomes
Status: NOT_YET_RECRUITING
Conditions: Kidney Failure, Chronic
Interventions: DRUG: Monofer (experimental)|DRUG: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FAST (Fluid Accumulation Status Trial)
Status: COMPLETED
Conditions: Congestive Heart Failure|Cardiomyopathy|Dyspnea|Pulmonary Edema|Heart Diseases
Interventions: DEVICE: Fluid Status Monitoring (OptiVol™)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Influence of an Inspiratory Muscle Fatigue Protocol on Healthy Youngs on Respiratory Muscle Strength, Vertical Jump Performance and Muscle Oxygen Saturation
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: OTHER: Inspiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Tolerability of Multiple Ascending Doses of REGN1033 (SAR391786)
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: REGN1033 (SAR391786)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of STSF Catheter Evaluated for Treating Symptomatic Persistent Atrial Fibrillation (PsAF)
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: THERMOCOOL SMARTTOUCH® SF catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hibiscus Sabdariffa Extract Effect on Neuromuscular Performance
Status: RECRUITING
Conditions: Neuromuscular Performance
Interventions: DIETARY_SUPPLEMENT: Hibiscus sabdariffa extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes
Status: RECRUITING
Conditions: Type 2 Diabetes|Heart Failure, Reduced Ejection Fraction
Interventions: DRUG: Ketone Monoester (KE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel Eluting Covered Metallic Stent for Unresectable Malignant Bile Duct Obstruction
Status: COMPLETED
Conditions: Bile Duct Obstruction
Interventions: DEVICE: Paclitaxel eluting covered metal stent and control covered metal stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Vinorelbine Liposomes Injection for Advanced Solid Tumors, Non-Hodgkin's Lymphoma or Hodgkin's Disease
Status: COMPLETED
Conditions: Tumors|Hodgkins Disease|Non-Hodgkins Lymphoma
Interventions: DRUG: VLI|DRUG: VLI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of SPL84 in Patients With Cystic Fibrosis
Status: RECRUITING
Conditions: Cystic Fibrosis
Interventions: DRUG: SPL84|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy and Safety of Simvastatin Alone Compared With Simvastatin Plus Ezetimibe in Type 2 Diabetic Patients (0653-021)(COMPLETED)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: MK0653, ezetimibe / Duration of Treatment: 30 Weeks|DRUG: Comparator : ezetimibe (+) simvastatin / Duration of Treatment: 30 Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Which Non-metastatic Castration-resistant Prostate Cancer (nmCRPC) Patients for Whom a Decision to Treat With Darolutamide Has Been Made Before Enrollment Are Observed and Certain Outcomes Are Described
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Darolutamide(Nubeqa, BAY1841788)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of the Results of Transcutaneous Carbon Dioxide and Oxygen Pressure in Premature Neonates Who Underwent MIST Under HHHFNC or Nasal CPAP Methods
Status: UNKNOWN
Conditions: Premature Birth|Respiratory Distress Syndrome|Surfactant Deficiency Syndrome Neonatal
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Effect of Adipose Tissue Derived Mesenchymal Stem Cells Implantation in Patients With Critical Limb Ischemia
Status: COMPLETED
Conditions: Critical Limb Ischemia
Interventions: PROCEDURE: Autologous Adipose Tissue derived MSCs Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of the TQB3602 Capsule Combined With AK105 Injection in Patients With Advanced Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Cancers
Interventions: DRUG: TQB3602 Capsule + AK105 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chevron Osteotomy Versus SCARF Osteotomy in the Treatment of Hallux Valgus
Status: COMPLETED
Conditions: Hallux Valgus
Interventions: PROCEDURE: Chevron osteotomy versus Scarf osteotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Open-label, Uncontrolled, Non-Interventional, Retrospective Study to Evaluate Molecular Determinants of Outcome to the Immune Checkpoint Inhibitors (Anti-PD-1/Anti-PD-L1 Monoclonal Antibodies) Treatment for Solid Tumors
Status: UNKNOWN
Conditions: Melanoma|Lung Cancer
Interventions: DRUG: Pembrolizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Computer-based Intervention for Alcohol-using HIV/HCV+ Women
Status: COMPLETED
Conditions: Human Immunodeficiency Virus|Hepatitis C|Alcohol Abuse
Interventions: BEHAVIORAL: Computer-based alcohol reduction intervention|BEHAVIORAL: Brief clinician-delivered MET|BEHAVIORAL: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An International Phase 2 Study Of SU011248 In Patients With Inoperable Liver Cancer
Status: COMPLETED
Conditions: Liver Neoplasms|Unresectable Hepatocellular Carcinoma
Interventions: DRUG: Sunitinib (SU011248)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Use of Noninvasive Ventilation in the Postoperative Period of Bariatric Surgery
Status: COMPLETED
Conditions: Bariatric Surgery Candidate|Obesity, Morbid|Ventilatory Failure
Interventions: DEVICE: Non invasive mechanical ventilation|DEVICE: GP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Immune Reconstitution in Tuberculosis Disease
Status: COMPLETED
Conditions: Pulmonary Tuberculosis (TB)
Interventions: DRUG: vitamin D (cholecalciferol) and PBA (sodium phenylbutyrate)|DRUG: Placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicentre, Randomized, Controlled Trial of Qideng Mingmu Capsule in The Treatment of Diabetic Retinopathy
Status: COMPLETED
Conditions: Diabetic Retinopathy|Diabetic Eye Problems|Retinal Disorders
Interventions: DRUG: Qideng Mingmu capsule|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extended Postoperative Oral Tranexamic Acid in Knee Replacement
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee Osteoarthritis|Blood Loss|Pain, Postoperative
Interventions: DRUG: Tranexamic Acid Pill|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Dose-dense (Biweekly) Carboplatin Plus Paclitaxel With or Without Trastuzumab as Neoadjuvant Treatment for Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: carboplatin and paclitaxel and or without trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long-term Extension Study for the Phase 3 Study of Nalmefene (339-14-001) in Patients With Alcohol Dependence
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: Nalmefene hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Protein and Retinol on Alcohol-induced FGF21
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Alcohol|OTHER: Alcohol+protein|OTHER: Alcohol+retinol|OTHER: Retinol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Predictors of Non-accESs to therapeutiC EducAtion Programs Among Patients With Type 2 Diabetes, and/or Asthma, and/or Chronic Heart Failure in an Emergency Setting
Status: COMPLETED
Conditions: Therapeutic Education Program|Emergencies|Diabetes|Asthma|Heart Failure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase I to Test a New Pneumococcal Vaccine
Status: COMPLETED
Conditions: Pneumococcal Pneumonia|Pneumonia, Bacterial
Interventions: BIOLOGICAL: Bioconjugate pneumococcal vaccine|BIOLOGICAL: Multivalent plain polysaccharide vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of a Mixed Distancial Neuropsychological Rehabilitation Program in Patients With Grade 2 or 3 Diffuse Glioma
Status: NOT_YET_RECRUITING
Conditions: Glioma, Malignant
Interventions: OTHER: Cognitive Behavioral Therapy (CBT) neuropsychologist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intralesional Influenza Vaccine for the Treatment of Stage I-IV Melanoma
Status: RECRUITING
Conditions: Clinical Stage I Cutaneous Melanoma AJCC v8|Clinical Stage IA Cutaneous Melanoma AJCC v8|Clinical Stage IB Cutaneous Melanoma AJCC v8|Clinical Stage II Cutaneous Melanoma AJCC v8|Clinical Stage IIA Cutaneous Melanoma AJCC v8|Clinical Stage IIB Cutaneous Melanoma AJCC v8|Clinical Stage IIC Cutaneous Melanoma AJCC v8|Clinical Stage IV Cutaneous Melanoma AJCC v8|Metastatic Melanoma
Interventions: BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab|BIOLOGICAL: Pembrolizumab|BIOLOGICAL: Quadrivalent Inactivated Influenza Vaccine|PROCEDURE: Resection|BIOLOGICAL: Nivolumab + Relatlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetically Engineered Cells (NY-ESO-1 TCR Engineered T Cells and HSCs) After Melphalan Conditioning Regimen in Treating Patients With Recurrent or Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Platinum-Resistant Fallopian Tube Carcinoma|Platinum-Resistant Ovarian Carcinoma|Platinum-Resistant Primary Peritoneal Carcinoma|Platinum-Sensitive Fallopian Tube Carcinoma|Platinum-Sensitive Ovarian Carcinoma|Platinum-Sensitive Primary Peritoneal Carcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Refractory Fallopian Tube Carcinoma|Refractory Ovarian Carcinoma|Refractory Primary Peritoneal Carcinoma
Interventions: BIOLOGICAL: Aldesleukin|BIOLOGICAL: Autologous NY-ESO-1-specific CD8-positive T Lymphocytes|OTHER: Cellular Therapy|DRUG: Melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Population Pharmacokinetics of Tranexamic Acid for Craniosynostosis Surgery
Status: COMPLETED
Conditions: Craniosynostosis
Interventions: DRUG: high dose TXA|DRUG: Low dose TXA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy Study of Canagliflozin or Sitagliptin to Determine Glucose Variability in Mexican Participants With Type 2 Diabetes Mellitus Inadequately Controlled on Metformin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Canagliflozin 300 mg|DRUG: Sitagliptin 100 mg|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Instructed Home-based Physical Exercise for Patients With Liver Cirrhosis
Status: RECRUITING
Conditions: Liver Cirrhosis
Interventions: BEHAVIORAL: Standard of Care advice on physical activity|BEHAVIORAL: Structured advice on physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)
Status: RECRUITING
Conditions: Immunoglobulin A Nephropathy|IgAN
Interventions: DRUG: Ravulizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Prehabilitation Program for High-risk Patients Underwent Abdominal Surgery
Status: COMPLETED
Conditions: Abdominal Surgical Patient|High-risk Patient
Interventions: BEHAVIORAL: Prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Right Ventricular Apical Versus True Mid-septal Pacing
Status: UNKNOWN
Conditions: Ventricular Rhythm From Artificial Pacing
Interventions: PROCEDURE: Pacing site - the implantation in the right ventricular (RV) apex|PROCEDURE: Pacing site - the implantation in the septum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Robotic-arm Assisted Ga-68 PSMA PET/CT Guided Transgluteal Prostate Biopsy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: Robotic arm assisted PSMA PET/CT guided prostate biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Immunotherapy Vaccine and Herceptin in Breast Cancer
Status: COMPLETED
Conditions: Breastcancer
Interventions: DRUG: GP2 peptide + GM-CSF vaccine plus trastuzumab|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Anti-CD19 CAR T-Cell Therapy, in Subjects With Refractory Primary and Secondary Progressive Multiple Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis, Primary Progressive|Multiple Sclerosis, Secondary Progressive|Multiple Sclerosis
Interventions: BIOLOGICAL: KYV-101|DRUG: Standard lymphodepletion regimen|DRUG: Anti-CD20 mAB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise, Activity and Smoking in Young Adults
Status: WITHDRAWN
Conditions: Exercise, Delayed Control
Interventions: BEHAVIORAL: High Intensity Interval Training|BEHAVIORAL: Moderate Intensity|BEHAVIORAL: Delayed Control|DEVICE: FitBit Flex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Changing the Course of Social Anxiety in Adolescence
Status: COMPLETED
Conditions: Social Anxiety Disorder
Interventions: BEHAVIORAL: Cognitive Therapy|BEHAVIORAL: Compassion-focused Therapy|BEHAVIORAL: Acceptance and Commitment Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Defining the Optimal Location to Place an Adductor Canal Block
Status: UNKNOWN
Conditions: Knee Arthropathy
Interventions: PROCEDURE: Placement of an adductor canal nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Aromatherapy Before Clinical Practice on Stress, Anxiety and Depression in Midwifery Students
Status: COMPLETED
Conditions: Aromatherapy|Stress|Depression
Interventions: OTHER: Petitgrain and ylang-ylang essential oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: CT-P13 (Infliximab) Subcutaneous Administration by Pre-filled Syringe and Auto-injector in Healthy Subjects
Status: COMPLETED
Conditions: Health, Subjective
Interventions: BIOLOGICAL: CT-P13 SC Auto-injector|BIOLOGICAL: CT-P13 SC Pre-filled Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety of Recombinant Human IL-21 Oncolytic Vaccinia Virus Injection（hV01) in Advanced Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: BIOLOGICAL: Recombinant human IL-21 oncolytic vaccinia virus injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Ranibizumab in Two "Treat and Extend" Treatment Algorithms Versus Ranibizumab As Needed in Patients With Macular Edema and Visual Impairment Secondary to Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Developing a New Metabolic Imaging Approach (aMRI) for Evaluating Neurological Disease in Patients With Gliomas
Status: RECRUITING
Conditions: Glioma
Interventions: OTHER: Fludeoxyglucose F-18|OTHER: Gadoterate Meglumine|PROCEDURE: Contrast-enhanced Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cold Induced Changes in White Adipose
Status: COMPLETED
Conditions: Obese|Normal Body Weight|Prediabetes|Metabolic Syndrome
Interventions: PROCEDURE: Fat biopsy|DRUG: Propranolol and fat biopsy|OTHER: heavy water and fat biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: VR-Moodboost; an Innovative Virtual Reality Treatment for Adolescents With Depression
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: BEHAVIORAL: VR-Moodboost; a Virtual Reality intervention for depression to enhance positive affect and reduce depressive symptoms.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AMDX-2011P Retinal Tracer in Subjects With Neurodegenerative Diseases Associated With Amyloidogenic Proteinopathy
Status: RECRUITING
Conditions: Parkinson Disease|Amyotrophic Lateral Sclerosis
Interventions: DRUG: AMDX2011P
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioequivalence Study of BAY77-1931 Granule
Status: COMPLETED
Conditions: Hyperphosphatemia
Interventions: DRUG: Lanthanum Carbonate (Fosrenol, BAY77-1931) Granule|DRUG: Lanthanum Carbonate (Fosrenol, BAY77-1931) Chewable tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetically Guided Endotracheal Intubation and Airway Cleaning Robot System
Status: UNKNOWN
Conditions: General Anesthesia
Interventions: DEVICE: Using robot system of endotracheal intubation and airway cleaning
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future
Status: NOT_YET_RECRUITING
Conditions: LVAD|Frailty|GI Bleed|Right Heart Failure|Infections|Hypertension|Arrhythmias|Stroke
Interventions: DEVICE: HeartMate 3 (R) left ventricular assist device
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Poor Ovarian Stimulation Response in In Vitro Fertilization (IVF) Program
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Human menopausal gonadotrophin (HMG)|DRUG: GnRH antagonist Cetrorelix|DRUG: Human chorionic gonadotrophin (hCG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study of the mTOR Inhibitor Rapamycin (Rapamune, Sirolimus) in Combination With Abraxane in Advanced Solid Cancers
Status: TERMINATED
Conditions: Advanced Solid Cancers
Interventions: DRUG: Rapamune|DRUG: Abraxane
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Hemodialysis With Medium Cut-off Dialyzer (Theranova) and High Flux Dialyzer
Status: COMPLETED
Conditions: End Stage Renal Disease|Dialysis Related Complication|Dialysis Amyloidosis
Interventions: DEVICE: Theranova-500 dialyzer|DEVICE: Elisio-21H
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Assessment of Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids
Status: WITHDRAWN
Conditions: Uterine Fibroids
Interventions: DRUG: Vilaprisan (BAY1002670)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects
Status: TERMINATED
Conditions: Cardiovascular Disease
Interventions: DRUG: bococizumab (PF-04950615)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Written Genetic Counseling and Mutation Analysis of BRCA1 and BRCA2 to Patients With Breast Cancer
Status: COMPLETED
Conditions: Hereditary Breast Cancer
Interventions: GENETIC: Germline genetic testing of BRCA1 and BRCA2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Clinical Study Evaluating the Safety and Efficacy of CS-101 in Treating Subjects With β-thalassemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Beta-Thalassemia
Interventions: BIOLOGICAL: CS-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritional Therapy for Autonomic Dysfunction in Elderly Heart Failure Patients
Status: COMPLETED
Conditions: Heart Failure
Interventions: DIETARY_SUPPLEMENT: Whey protein powder and L-carnitine|DIETARY_SUPPLEMENT: Maltodextrin placebo powder and Psyllium Husk capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of the Effect of Montelukast and Cetirizine on Allergic Inflammation in Children With Allergic Rhinitis
Status: UNKNOWN
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: montelukast|DRUG: cetirizine|DRUG: montelukast and cetirizine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Conventional Fluid Management Protocol With Targeted Pleth Variability Index (PVI) Monitoring Protocol During Total Abdominal Hysterectomy and Bilateral Salpingooferectomy Operation
Status: COMPLETED
Conditions: Intraoperative Hypotension|Intraoperative Complications|Hypervolemia|Acute Renal Failure|Perioperative/Postoperative Complications|Volume Overload
Interventions: OTHER: Pleth Variability Index|OTHER: Conventional fluid theraphy|OTHER: Anesthesia method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Compare Nighttime Aligners to Daytime Aligners
Status: NOT_YET_RECRUITING
Conditions: Teeth Straightening|Aligner Therapy|Orthodontic Aligner
Interventions: DEVICE: Nighttime Aligners|DEVICE: Daytime Aligners
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heat Transfer by Three Types of Packs and Its Implication on the Flexibility of the Lower Back
Status: COMPLETED
Conditions: Physical Therapy Techniques
Interventions: OTHER: moist heat pack; ;|OTHER: seed pack|OTHER: gel pack
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)
Status: RECRUITING
Conditions: Type 2 Diabetes Mellitus|Diabetic Kidney Disease|Adolescent Obesity|Pre Diabetes|Kidney Hypoxia|Puberty
Interventions: DRUG: Aminohippurate Sodium Inj 20%|DRUG: Iohexol Inj 300 MG/ML|DRUG: Dextran 40
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MI-CBT Adherence Program for Lifestyle Interventions in Older Adults
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Adherence, Patient|Ketosis
Interventions: BEHAVIORAL: Motivational Interviewing-Cognitive Behavioral Therapy Ketogenic Nutrition Adherence Program|OTHER: Ketogenic Nutrition Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Number of Rank of B-lactam Antibiotics on Emergence on Multidrug Resistant Bacteria
Status: UNKNOWN
Conditions: Resistant Infection|Antibiotic Resistant Infection|Beta Lactam Resistant Bacterial Infection|Bacterial Resistance
Interventions: PROCEDURE: number of Beta lactam class prescription for the same infection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Monoclonal Antibody Therapy With Sargramostim and Interleukin-2 in Treating Children With Neuroblastoma
Status: COMPLETED
Conditions: Disseminated Neuroblastoma|Recurrent Neuroblastoma|Regional Neuroblastoma
Interventions: BIOLOGICAL: monoclonal antibody Ch14.18|DRUG: isotretinoin|BIOLOGICAL: aldesleukin|BIOLOGICAL: sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Establishing Daily Applicable Parameters for Using Magnetic Resonance Spectroscopy of Spinal Cord
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord
Interventions: DIAGNOSTIC_TEST: Magnetic Resonance Spectroscopy (MRS) Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Study of the Immunogenicity of GSK Biologicals' Influenza Vaccine GSK2186877A in People Aged 65 Years or Older
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: GSK Biologicals' influenza vaccine GSK2186877A|BIOLOGICAL: GSK Biologicals' Fluarix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tarceva and AT-101 for Patients With Advanced Non-Small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Carcinoma, Non Small Cell Lung
Interventions: DRUG: Tarceva plus AT-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of VcR-CVAD With Rituximab Consolidation and Maintenance for Untreated Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Bortezomib|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Unfiltered Cigarettes Among Committed Smokers
Status: COMPLETED
Conditions: Cigarette Smoking|Tobacco Smoking
Interventions: OTHER: Unfiltered Cigarettes|OTHER: Filtered Cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety of Platelet Transfusion in Patients on Antiplatelet Therapy With Traumatic Head Injury
Status: TERMINATED
Conditions: Traumatic Head Injury|Intracranial Hemmorhage|Anti-platelet Therapy
Interventions: OTHER: Saline|OTHER: Platelets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electroacupuncture vs. Sham Electroacupuncture for Treatment of Fatigue in Patients With Inflammatory Bowel Disease
Status: COMPLETED
Conditions: Fatigue|Inflammatory Bowel Disease
Interventions: OTHER: electroacupuncture|OTHER: Sham: Electroacupuncture sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Weekly Phone Calls Versus Brief Patient Education to Improve Continuous Positive Airway Pressure (CPAP) Compliance
Status: COMPLETED
Conditions: Obstructive Sleep Apnea (OSA)
Interventions: BEHAVIORAL: Weekly phone calls|BEHAVIORAL: Frequently asked questions|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Nephroprotective Effect of Metformin With Cisplatin in Bladder Cancer
Status: RECRUITING
Conditions: Muscle-Invasive Bladder Carcinoma
Interventions: DRUG: Metformin Hydrochloride 500 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PIONEER III Trial to Assess Safety and Efficacy of the BuMA Supreme™ Drug Coated Coronary Stent in Patients With Coronary Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: BuMA Supreme DES|DEVICE: Xience or Promus DES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Staples Versus Subcuticular Suture in Class III Obese Women Undergoing Cesarean Delivery
Status: COMPLETED
Conditions: Obesity, Severe|Cesarean Section
Interventions: DEVICE: Absorbable subcuticular suture|DEVICE: Stainless steel staples
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RUCONEST® as a Therapeutic Strategy to Reduce the Incidence of Delayed Graft Function
Status: UNKNOWN
Conditions: Kidney Failure
Interventions: DRUG: rhC1INH|OTHER: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Alogliptin and Pioglitazone in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Alogliptin|DRUG: Pioglitazone|DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase IV Clinical Study of Immunogenicity of ACYW135 Group Meningococcal Polysaccharide Conjugate Vaccine (CRM197 Vector)
Status: RECRUITING
Conditions: Epidemic Meningitis
Interventions: BIOLOGICAL: MCV4|BIOLOGICAL: MCV4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Idiopathic Normal Pressure Hydrocephalus: Focus on Imaging and Clinical Symptoms.
Status: RECRUITING
Conditions: Fecal Incontinence With Fecal Urgency|Urine Incontinence|Diffusion Tensor Imaging|Leukoencephalopathies
Interventions: PROCEDURE: Shunt surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Uterine Transplant for Women With Absolute Uterine Factor Infertility (AUFI)
Status: RECRUITING
Conditions: Mayer Rokitansky Kuster Hauser Syndrome|Absence of Uterus|Infertility of Uterine Origin
Interventions: OTHER: Uterine Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT