pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Efficacy Study of LHW090 in Resistant Hypertension Patients
Status: COMPLETED
Conditions: Patients, Resistant Hypertension
Interventions: DRUG: LHW090|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reciprocal Inhibition Versus Reciprocal Facilitation In Spinal Cord Injury Patients
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: DIAGNOSTIC_TEST: Tendon tap|DIAGNOSTIC_TEST: Tibial nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: High Volume Simethicone VCE Clinical Trial
Status: COMPLETED
Conditions: Small Bowel Diseases
Interventions: DRUG: High Volume Simethicone|DRUG: Standard Volume Simethicone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Endoscopically Assisted Colostomy With Colopexy for Critically Ill Patients Without General Anesthesia or Laparotomy
Status: COMPLETED
Conditions: Colonic Neoplasms|Rectal Neoplasms|Fecal Incontinence
Interventions: PROCEDURE: ENDOSCOPICALLY ASSISTED COLOSTOMY WITH COLOPEXY
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sofosbuvir/Velpatasvir Fixed Dose Combination for 12 Weeks in Adults With Chronic Hepatitis C Virus (HCV) Infection
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: SOF/VEL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of mRNA-2752 for Intratumoral Injection to Participants in Advanced Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Dose Escalation: Relapsed/Refractory Solid Tumor Malignancies or Lymphoma|Dose Expansion: Triple Negative Breast Cancer, HNSCC, Non-Hodgkins, Urothelial Cancer, Immune Checkpoint Refractory Melanoma, and NSCLC Lymphoma
Interventions: BIOLOGICAL: mRNA-2752|BIOLOGICAL: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effectiveness of a Virtual Reality Treatment in the Management of Smoking Cessation
Status: RECRUITING
Conditions: Tobacco Use Cessation
Interventions: BEHAVIORAL: Virtual Reality-Enhanced Cognitive Behavioral Therapy (VR-CBT)|BEHAVIORAL: cognitive behavior therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thymus Transplantation Safety-Efficacy
Status: COMPLETED
Conditions: Complete DiGeorge Anomaly|DiGeorge Syndrome|DiGeorge Anomaly|Complete DiGeorge Syndrome
Interventions: BIOLOGICAL: Cultured Thymus Tissue|PROCEDURE: Blood Draw|DRUG: Rabbit anti-thymocyte globulin|DRUG: Cyclosporine|DRUG: Tacrolimus|DRUG: Methylprednisolone or Prednisolone|DRUG: Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: M6620 and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Colorectal Carcinoma|Metastatic Lung Small Cell Carcinoma|Metastatic Malignant Solid Neoplasm|Metastatic Pancreatic Carcinoma|Refractory Colorectal Carcinoma|Refractory Lung Small Cell Carcinoma|Refractory Malignant Solid Neoplasm|Refractory Pancreatic Carcinoma|Stage III Colorectal Cancer AJCC v8|Stage III Lung Cancer AJCC v8|Stage III Pancreatic Cancer AJCC v8|Stage IV Colorectal Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8|Unresectable Colorectal Carcinoma|Unresectable Lung Small Cell Carcinoma|Unresectable Malignant Solid Neoplasm|Unresectable Pancreatic Carcinoma
Interventions: DRUG: Berzosertib|PROCEDURE: Biopsy Specimen|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Irinotecan Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Show Equivalence of the Modified BreathID Compared to Currently Approved BreathID in H.Pylori Detection
Status: COMPLETED
Conditions: Suspicion of Being Infected With H.Pylori
Interventions: DEVICE: Modified BreathID
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Methotrexate, Glucarpidase, and Leucovorin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma
Status: COMPLETED
Conditions: Chemotherapeutic Agent Toxicity|Lymphoma|Mucositis|Neurotoxicity
Interventions: DRUG: glucarpidase|DRUG: leucovorin calcium|DRUG: methotrexate|OTHER: laboratory biomarker analysis|PROCEDURE: quality-of-life assessment|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Outcomes of Ataluren in Duchenne Muscular Dystrophy
Status: COMPLETED
Conditions: Muscular Dystrophy, Duchenne|Muscular Dystrophies|Muscular Disorders, Atrophic|Muscular Diseases|Musculoskeletal Disease|Neuromuscular Diseases|Nervous System Diseases|Genetic Diseases, X-Linked|Genetic Diseases, Inborn
Interventions: DRUG: Ataluren|DRUG: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Ujiplus® Against Schistosoma Mansoni
Status: COMPLETED
Conditions: Schistosoma Mansoni
Interventions: DIETARY_SUPPLEMENT: Ujiplus®|DRUG: Praziquantel 400mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Calcitriol Plus Dexamethasone in Treating Patients With Prostate Cancer That Has Not Responded to Hormone Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: calcitriol|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GEN1029 (HexaBody®-DR5/DR5) Safety Trial in Patients With Malignant Solid Tumors
Status: TERMINATED
Conditions: Colorectal Cancer|Non-small Cell Lung Cancer|Triple Negative Breast Cancer|Renal Cell Carcinoma|Gastric Cancer|Pancreatic Cancer|Urothelial Cancer
Interventions: BIOLOGICAL: GEN1029 (HexaBody®-DR5/DR5)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Analgesia With a Catheter Under the Erector Spinae Muscle for Videothoracoscopic Lung Surgery
Status: COMPLETED
Conditions: Neoplasm of Lung|Thoracic Surgery, Video-Assisted
Interventions: PROCEDURE: Erector Spinae Catheter|PROCEDURE: Intercostal block|DRUG: Ropivacaine 0.2% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tildrakizumab Compared to Placebo in Anti-TNF naïve Subjects With Active Psoriatic Arthritis II (INSPIRE 2)
Status: ACTIVE_NOT_RECRUITING
Conditions: Active Psoriatic Arthritis
Interventions: DRUG: TILD|DRUG: matching placebo injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Chinese Participants With B-Cell Malignancies With BGB-16673, a Bruton Tyrosine Kinase-Targeted Protein-Degrader
Status: RECRUITING
Conditions: B-cell Malignancy|Non-Hodgkin Lymphoma|Mantle Cell Lymphoma|Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma|Waldenström Macroglobulinemia|Marginal Zone Lymphoma|Follicular Lymphoma|DLBCL Unclassifiable|Richter's Transformation
Interventions: DRUG: BGB-16673
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Weight Loss and Dietary Protein Intake on Bone
Status: COMPLETED
Conditions: Weight Loss|Bone Density
Interventions: BEHAVIORAL: Caloric restriction, high protein|BEHAVIORAL: Caloric restriction; normal protein|BEHAVIORAL: Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beetroot Juice Supplementation in Basketball Players
Status: COMPLETED
Conditions: Dietary Supplement|Sport Performance
Interventions: DIETARY_SUPPLEMENT: Beetroot juice (BJ) acute supplementation|DIETARY_SUPPLEMENT: Placebo acute supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug Eluting Stent Zilver PTX vs Bare Metal Stent Zilver Flex
Status: COMPLETED
Conditions: Vascular Diseases
Interventions: DEVICE: Treatment with Zilver PTX Drug Eluting Stent (DES) in femoropopliteal lesions|DEVICE: Treatment with Zilver Flex Bare Metal Stent (BMS) in femoropopliteal lesions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Itacitinib in Combination With Erlotinib in Non Small Cell Lung Cancer Patients With Epidermal Growth Factor Receptor (EGFR) Activating Mutations
Status: WITHDRAWN
Conditions: Solid Tumors and Hematologic Malignancy|NSCLC (Non-small Cell Lung Carcinoma)
Interventions: DRUG: Itacitinib|DRUG: erlotinib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Skin-to-skin Contact Between Premature Infant and Mother
Status: COMPLETED
Conditions: Kangaroo-mother Care
Interventions: OTHER: kangaroo mother care (KMC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gemcitabine and Bexarotene in Treating Patients With Progressive or Refractory Stage IB, Stage II, Stage III, or Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: bexarotene|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erlotinib and Sirolimus in Treating Patients With Recurrent Malignant Glioma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: Erlotinib + Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Haloperidol Versus Ondansetron for Treatment of Established Post-operative Nausea and Vomiting
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: 4 mg of Ondansetron IV|DRUG: 1mg of Haloperidol IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of TOT on Performance, Independence and Fatigue in Children With Cancer
Status: COMPLETED
Conditions: Childhood Cancer|Performance|Functional Independence|Fatigue
Interventions: OTHER: task-oriented training (TOT)|OTHER: conventional occupational therapy (COT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Apatinib Plus Docetaxel in Advanced Non-squamous Non-small Cell Lung Cancer(NSCLC)
Status: UNKNOWN
Conditions: NSCLC
Interventions: DRUG: Apatinib|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The OPTIMAL TDM Study: Determining Optimal Beta-lactam Plasma Concentrations Through Therapeutic Drug Monitoring
Status: RECRUITING
Conditions: Beta-lactam Antibiotics|Therapeutic Drug Monitoring|Toxicity|Efficacy|Imipenem|Meropenem|Piperacillin|Flucloxacillin|Amoxicillin|Ceftazidime|Cefepime
Interventions: OTHER: The study is observational.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect Of Acetazolamide On Altitude Related Illness In Patients With Respiratory Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: ACETAZOLAMIDE oral capsule|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Demonstration Study of the Effect of the Transcranial Direct Current Stimulation (tDCS) on Depressed Patients
Status: RECRUITING
Conditions: Depression
Interventions: DEVICE: transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Bio-psychosocial Sexual Health Intervention for Prostate Cancer Survivors and Partners: a Feasibility Study
Status: COMPLETED
Conditions: Prostate Cancer|Erectile Dysfunction|Sexual Dysfunction
Interventions: BEHAVIORAL: Biomedical Component|BEHAVIORAL: Psychosocial Component|BEHAVIORAL: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vorinostat, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Status: COMPLETED
Conditions: Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma
Interventions: RADIATION: 3-Dimensional Conformal Radiation Therapy|PROCEDURE: Cognitive Assessment|OTHER: Laboratory Biomarker Analysis|DRUG: Temozolomide|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: China Resolute Integrity 34/38 mm Study
Status: COMPLETED
Conditions: Ischemic Heart Disease|Stenotic Coronary Lesion|Cardiovascular Diseases|Arteriosclerosis|Coronary Artery Disease
Interventions: DEVICE: Resolute Integrity™ Zotarolimus-Eluting Coronary Stent System(34/38 mm)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Taking Account of Inobservable Periods in Longitudinal Drug Treatment Follow-up
Status: COMPLETED
Conditions: Drug Exposition
Interventions: OTHER: Exposition to hypnotics or anxiolytics benzodiazepines|OTHER: Exposition to non benzodiazepines antidepressants, hypnotics or anxiolytics|OTHER: Medical consultation without prescription|OTHER: Administrative and medical data
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Canakinumab for the Prevention of Progression to Cancer in Patients With Clonal Cytopenias of Unknown Significance, IMPACT Study
Status: RECRUITING
Conditions: Clonal Cytopenia of Undetermined Significance
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration and Biopsy|DRUG: Canakinumab|PROCEDURE: Chest Radiography|PROCEDURE: Echocardiography|DRUG: Placebo Administration|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Evaluation and Local Tolerability of Dry Powder Amikacin Via the Cyclops™
Status: UNKNOWN
Conditions: Tuberculosis
Interventions: DRUG: Amikacin Inhalation Dry Powder|DRUG: Amikacin Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HKT-500-US12 In Adult Patients With OA Knee Pain
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: HKT-500 Topical Patch|OTHER: Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Effect of Mask Use on Hemodynamic Responses During Exertion
Status: COMPLETED
Conditions: COVID-19|Heart Rate|Blood Pressure|Exercise Test|Mask
Interventions: DEVICE: Treadmilll|OTHER: mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study To Evaluate The Effect Of Torcetrapib/Atorvastatin In Subjects With A Genetic Cholesterol Disorder.
Status: TERMINATED
Conditions: Hyperlipoproteinemia Type III
Interventions: DRUG: torcetrapib/atorvastatin|DRUG: atorvastatin|DRUG: fenofibrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparative Bioavailability Study of Two Misoprostol Formulations
Status: COMPLETED
Conditions: Labour, Induced
Interventions: DRUG: Angusta™|DRUG: Cytotec®|DRUG: Angusta™|DRUG: Cytotec®|DRUG: Angusta™|DRUG: Cytotec®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of an Optimal Algorithm for the Management of Patients With Retinal Pigment Epithelium Detachment in Neovascular Age-related Macular Degeneration Using Artificial Intelligence
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: PROCEDURE: Anti-vascular endothelial growth factor therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Changes in the Immunomodulatory Properties of Adipose Stromal Cells Due to Hemarthrosis After Knee Injury
Status: RECRUITING
Conditions: Post-Traumatic Osteoarthritis of Knee|Knee Injuries|Hemarthrosis
Interventions: PROCEDURE: knee arthrocentesis|PROCEDURE: venipuncture|DIAGNOSTIC_TEST: MRI-scan|DIAGNOSTIC_TEST: Physical examination|OTHER: KOOS questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Efficacy of Single-dose Doxycycline Versus Standard 5- Day Amoxicillin Treatment
Status: COMPLETED
Conditions: Fever
Interventions: DRUG: Doxycycline|DRUG: Amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial on the Effect of Isatuximab to Lenalidomide/Bortezomib/Dexamethasone (RVd) Induction and Lenalidomide Maintenance in Patients With Newly Diagnosed Myeloma (GMMG HD7)
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Lenalidomide|DRUG: Bortezomib|DRUG: Dexamethasone|DRUG: Isatuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resistant Starch Wheat for Improved Metabolic Health
Status: COMPLETED
Conditions: Gut Microbiota|Metabolism|Metabolic Health
Interventions: DIETARY_SUPPLEMENT: Resistant Starch Wheat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Occipital Nerve Stimulation in Medically Intractable Chronic Cluster Headache
Status: COMPLETED
Conditions: Chronic Cluster Headache
Interventions: DEVICE: occipital nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Grape Seed Extract VS Low Level Laser Therapy for Dentin Hypersensitivity
Status: RECRUITING
Conditions: Dentin Hypersensitivity
Interventions: DRUG: Grape Seed Extract|DEVICE: Low-level laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LiuWeiLuoBi Granule for the Treatment of Diabetic Peripheral Neuropathy
Status: RECRUITING
Conditions: Diabetic Peripheral Neuropathy|Chinese Medicine|Nerve Conduction
Interventions: DRUG: LiuWeiLuoBi Granule|OTHER: Standard medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin, Capecitabine, and Radiation Therapy in Treating Patients With Locally Advanced Cancer of the Rectum
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: capecitabine|DRUG: oxaliplatin|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Conventional Therapy Plus Pulsed-Radiofrequency for Herniated Nucleus Pulposus
Status: COMPLETED
Conditions: Herniated Nucleus Pulposus|Pain
Interventions: PROCEDURE: Pulsed radiofrequency|OTHER: Conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet Based Parenting Education and Information -Motivation-Behavioral Skills (IMB) Model
Status: COMPLETED
Conditions: Parenting|Maternal-Fetal Relations|Paternal Behavior
Interventions: OTHER: Internet-based Parenting Education based on the information -Motivation-Behavioral Skills (IMB) Model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Inhibition of Gastric Acid is the Key to Satisfactory Relief of Symptoms With Esomeprazole in NUD Patients
Status: COMPLETED
Conditions: Indigestion
Interventions: DRUG: Esomeprazole|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GLP1-imaging Before and After Bariatric Surgery
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Bariatric Surgery Candidate
Interventions: RADIATION: 68Ga-NODAGA-exendin-4 PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treating Locally Advanced Rectal Cancer With TAS-102 Chemotherapy Plus Neoadjuvant Radiotherapy
Status: NOT_YET_RECRUITING
Conditions: Rectal Cancer
Interventions: DRUG: Trifluridine/Tipiracil|RADIATION: intensity-modulated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Clinical Efficacy of the Heart Spectrum Blood Pressure Monitor for Diagnosis of Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Heart Spectrum Blood Pressure Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Restoring Central Motor Control Extension
Status: WITHDRAWN
Conditions: Gait, Unsteady
Interventions: BEHAVIORAL: Strength training|BEHAVIORAL: Endurance training|BEHAVIORAL: Flexibility training|BEHAVIORAL: Physical activity behavioral intervention|BEHAVIORAL: Task Specific timing and coordination training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mechanistic Evaluation of Glucose-lowering Strategies in Patients With Heart Failure
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Heart Failure
Interventions: DRUG: Saxagliptin|DRUG: Sitagliptin|DRUG: Placebo to match saxagliptin|DRUG: Placebo to match sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NanaBis™ an Oro-buccal Administered delta9-Tetrahydrocannabinol (d9-THC) & Cannabidiol (CBD) Medicine for the Management of Bone Pain From Metastatic Cancers
Status: UNKNOWN
Conditions: Cancer Related Pain
Interventions: DRUG: NanaBis™|DRUG: Oxycodone CR|DRUG: Placebo Spray|DRUG: Placebo Tablet|DRUG: Oxycodone IR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes of Functional Connectivity After rTMS in Depression
Status: COMPLETED
Conditions: Major Depression
Interventions: DEVICE: repetitive transcranial magnetic stimulation(rTMS)|DEVICE: Sham repetitive transcranial magnetic stimulation(rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Xeltis Hemodialysis Access Graft (aXess) US Study
Status: NOT_YET_RECRUITING
Conditions: End Stage Renal Disease
Interventions: DEVICE: Xeltis Hemodialysis Access (aXess) graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Evidence Improved Cranial Flap Fixation With a Bioresorbable Bone Adhesive
Status: RECRUITING
Conditions: Craniotomy
Interventions: DEVICE: Tetranite for Cranial Flap Fixation (TN-CFF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Trial to Explore Safety of Combining Afatinib (BIBW 2992) and Radiotherapy With or Without Temozolomide in Newly Diagnosed Glioblastoma Multiform
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: Temozolomide|PROCEDURE: Radiotherapy|DRUG: BIBW2992|PROCEDURE: Radiotherapy|DRUG: BIBW2992
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Efficacy of ARCO
Status: COMPLETED
Conditions: Plasmodium Falciparum|Malaria, Falciparum
Interventions: DRUG: artemisinin/naphthoquine|DRUG: dihydroartemisinin/piperaquine phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reliability of Dynamic Contour Tonometry (DCT)
Status: COMPLETED
Conditions: Intraocular Pressure|Central Corneal Thickness
Interventions: DEVICE: DCT (PASCAL© Tonometer) IOP and OPA measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of NCS-01 in Patients With Acute Ischemic Stroke
Status: ACTIVE_NOT_RECRUITING
Conditions: Ischemic Stroke
Interventions: BIOLOGICAL: NCS-01
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Chronic Delta Hepatitis With Lonafarnib and Ritonavir
Status: COMPLETED
Conditions: Hepatitis D
Interventions: DRUG: Lonafarnib|DRUG: Ritonavir|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Acceptability of Long-Acting Cabotegravir (CAB LA) for the Prevention of HIV Among Adolescent Females
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Oral cabotegravir (CAB)|DRUG: CAB LA|DRUG: Oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating Venetoclax in Subjects With Hematological Malignancies
Status: COMPLETED
Conditions: Non-Hodgkin Lymphoma (NHL)|Multiple Myeloma (MM)|Chronic Lymphocytic Leukemia (CLL)|Small Lymphocytic Lymphoma (SLL)|Acute Myeloid Leukemia (AML)
Interventions: DRUG: azacitadine|DRUG: venetoclax|DRUG: rituximab / IDEC-C2B8|DRUG: rituximab / IDEC-C2B8
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Active Immunotherapy Of Metastatic Renal Cell Carcinoma Using Autologous Dendritic Cells Transfected With Autologous Total Tumor RNA
Status: UNKNOWN
Conditions: Renal Cell Carcinoma
Interventions: BIOLOGICAL: DC RCC-RNA
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Fluorouracil Plus Leucovorin With or Without Oxaliplatin in Treating Patients With Stage II or Stage III Colon Cancer
Status: COMPLETED
Conditions: Stage II Colon Cancer|Stage III Colon Cancer
Interventions: DRUG: leucovorin calcium|DRUG: fluorouracil|DRUG: oxaliplatin|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Effect of Echogenic Needle for Nerve Block on Acute and Chronic Postoperative Pain
Status: RECRUITING
Conditions: Chronic Postoperative Pain
Interventions: PROCEDURE: Echogenic nerve block needle|PROCEDURE: Non-echogenic nerve block needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: IDO2 Genetic Status Informs the Neoadjuvant Efficacy of Chloroquine (CQ) in Brain Metastasis Radiotherapy
Status: COMPLETED
Conditions: Brain Metastasis
Interventions: DRUG: Chloroquine diphosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ED Patient's Perceptions and Acceptability Toward a Novel POC HCV Viral Load Testing
Status: NOT_YET_RECRUITING
Conditions: Hepatitis C
Interventions: DIAGNOSTIC_TEST: Xpert HCV Viral Load Finger-stick Point-of-Care test (Cepheid)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Oral Diclofenac Sodium Versus Oral Hyoscine Butyl Bromide During Intrauterine Device Insertion
Status: COMPLETED
Conditions: Family Planning
Interventions: DRUG: diclofenac sodium (cataflam)|DRUG: hyoscine butyl bromide (buscopan)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Efficacy and Safety of Umbralisib in Participants With Non-Follicular Indolent Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Marginal Zone Lymphoma|Waldenstrom Macroglobulinemia|Non Follicular Indolent Non-Hodgkin Lymphoma
Interventions: DRUG: Umbralisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CETRA: Neoadjuvant Caelyx and Trastuzumab in Her-2 Positive Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: docetaxel|DRUG: cyclophosphamide|DRUG: trastuzumab|DRUG: liposomal doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient-clinical Linkages to Improve Trust and Engagement in Postpartum Healthcare
Status: NOT_YET_RECRUITING
Conditions: Family Dynamics|Trust in Healthcare System|Family Structure|Health Literacy|Contraception|Maternal Behavior|Postpartum Mood Disturbance
Interventions: BEHAVIORAL: The PEN-3 Intervention Model
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 'Pre-Proof of Concept (Pre-POC)' Clinical Trials to Optimize Lead Microbiota-directed Complementary Food (MDCF) Prototypes for Their Ability to Repair Microbiota Immaturity and Establish Their Organoleptic Acceptability
Status: UNKNOWN
Conditions: Pre Proof of Concept Clinical Trial
Interventions: DIETARY_SUPPLEMENT: Microbiota Directed Complementary Food (MDCF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Autologous, Adult Adipose-Derived Stem/Stromal Cells in Inflammatory Bowel Disease
Status: ENROLLING_BY_INVITATION
Conditions: Inflammatory Bowel Diseases
Interventions: PROCEDURE: Lipoaspiration|PROCEDURE: AD-cSVF|PROCEDURE: Normal Saline IV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Safety and Efficacy of NT-501 With MHFM
Status: NOT_YET_RECRUITING
Conditions: Macular Telangiectasia Type 2
Interventions: COMBINATION_PRODUCT: NT-501 CNTF Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Resistance and Stretching Training Program on Forward Head and Protracted Shoulder Posture Adolescents
Status: COMPLETED
Conditions: Posture Disorders in Children
Interventions: OTHER: Interventional program postural correction training|OTHER: Control Group physical education classes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of hUC-MSCs and hUCB-MSCs in the Treatment of Chronic Spinal Cord Injury
Status: UNKNOWN
Conditions: Spinal Cord Injuries
Interventions: OTHER: Stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online Psychosocial Support for Young People With a Visible Difference: A Randomised Control Study
Status: ENROLLING_BY_INVITATION
Conditions: Skin Condition|Cleft Lip and Palate|Burns|Other Conditions Leading to a Visible Difference|Craniofacial Abnormalities
Interventions: OTHER: Ung Face IT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Pharmacokinetics and Safety of GSK1265744 and Rilpivirine and Dolutegravir and Rilpivirine in Healthy Adult Subjects
Status: COMPLETED
Conditions: Infections, Human Immunodeficiency Virus and Hepatitis
Interventions: DRUG: Dolutegravir|DRUG: Rlipivirine|DRUG: GSK1265744
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Effect Of Plasma Rich In Growth Factors In Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: BIOLOGICAL: Plasma rich in growth factors|DRUG: Hyaluronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Application of 3-Dimensional Printing Guide Template and Pointed Lotus-style Regulator
Status: COMPLETED
Conditions: Vertebral Fracture
Interventions: DEVICE: Pointed lotus root regulator and guide template aided PPSF|DEVICE: Flat ended lotus root regulator and guide template aided PPSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Lab Study of MQX-503 in Treatment of Raynaud's
Status: COMPLETED
Conditions: Raynaud Disease|Raynaud Disease Secondary to Scleroderma|Raynaud Secondary to Other Autoimmune Disease
Interventions: DRUG: topical organogel with nitroglycerin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Efficacy of a Single Layer Placental-based Allograft and Standard of Care Versus Standard of Care
Status: NOT_YET_RECRUITING
Conditions: Diabetic Foot Ulcer|Diabetic Foot|Foot Ulcer|Ulcer Foot
Interventions: OTHER: SLAM + SOC|OTHER: SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Raltegravir in HIV-1-Exposed Newborn Infants at Risk of Acquiring HIV-1 Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Raltegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Pleiotropic Effects of Atorvastatin When Combined With Common Antihypertenisve Medications.
Status: WITHDRAWN
Conditions: Hypertension
Interventions: DRUG: Amlodipine and Hydrocholorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility, Safety, and Efficacy of Stereotactic MRI-Guided Adaptive Radiation Therapy (SMART) for Central Lung Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer
Interventions: OTHER: Simulated Online Adaptive Planning|RADIATION: Stereotactic MRI-guided adaptive radiotherapy-SMART
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Study of Hippocampal Electrical Stimulation (HS, in Mesial Temporal Lobe Epilepsy
Status: TERMINATED
Conditions: Temporal Lobe Epilepsy
Interventions: PROCEDURE: Hippocampal Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Examine Pain Relief With Supplemental Intrathecal Morphine in TKA Patients
Status: UNKNOWN
Conditions: Acute Pain
Interventions: DRUG: Morphine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Relative Bioavailability Study of IX-01 Caplet Versus Aqueous Dispersion and Food Effect of the Caplet in Healthy Males
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: IX-01 caplets 1600 mg (4 x 400 mg), fasted|DRUG: IX-01 caplets 1600 mg (4 x 400 mg), fed|DRUG: IX-01 aqueous dispersion 1600 mg (20 mL), fasted
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Shotgun Mass Spectrometry-based Lipid Profiling in Chronic Inflammatory Diseases
Status: COMPLETED
Conditions: Biomarker|Lipid|Inflammation|Cardiovascular Diseases|Ischemic Stroke|Systemic Lupus Erythematosus|Healthy
Interventions: OTHER: Blood collection for lipid profiling by LC-MS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Caffeine Supplementation and Personalized Insoles on Females
Status: SUSPENDED
Conditions: Caffeine|Fatigue|Injuries|Females Xy|Soccer|Biomechanical Parameters
Interventions: DIETARY_SUPPLEMENT: Caffeine supplementation|DEVICE: Personalized insoles|OTHER: Control condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Cesarean Wound Closure in Women With BMI 40 or Greater
Status: COMPLETED
Conditions: C.Delivery; Penetration, Pregnant Uterus, by Instrument|Obesity
Interventions: PROCEDURE: Randomizing to Suture or Staple closure of Cesarean section
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effectiveness of Sertraline in Treating Pathological Gamblers With a Diagnosis of Alcohol Dependence - 1
Status: TERMINATED
Conditions: Alcoholism|Gambling
Interventions: DRUG: Sertraline|BEHAVIORAL: Relapse Prevention Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Of An Education Plan And Adherence Follow-Up To The Exercise In Patients With Angioplasty And Stent Coronary
Status: COMPLETED
Conditions: Patient Adherence
Interventions: BEHAVIORAL: Education plan and adherence to exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Volumetric Imaging Follow up of Patients With Liver Metastases of Small Intestinal Neuroendocrine Tumors (NETs).
Status: UNKNOWN
Conditions: Neuroendocrine Tumors|Liver Metastases
Interventions: OTHER: Volumetric measurements of liver metastases
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of STARgraft AV for Hemodialysis Access
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DEVICE: STARgraft AV|DEVICE: ePTFE AV graft (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Cobimetinib and Atezolizumab in Treating Participants With Advanced or Refractory Rare Tumors
Status: COMPLETED
Conditions: Skin Squamous Cell Carcinoma|Appendix Adenocarcinoma|Rare Lesion|Locally Advanced Malignant Neoplasm|Locally Advanced Skin Squamous Cell Carcinoma|Metastatic Malignant Neoplasm|Metastatic Skin Squamous Cell Carcinoma|Metastatic Small Intestinal Adenocarcinoma|Rare Neoplastic Syndrome|Refractory Malignant Neoplasm|Stage IV Small Intestinal Adenocarcinoma AJCC v8|Unresectable Malignant Neoplasm
Interventions: DRUG: Atezolizumab|DRUG: Cobimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Clinical Human Tolerability Study of Recombinant Mycobacterium Tuberculosis Allergen ESAT6-CFP10
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: ESAT6-CFP10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Case Series Evaluation of a Short Dental Implant
Status: WITHDRAWN
Conditions: Tooth Loss
Interventions: DEVICE: A minimum of two but up to three Astra Tech Dental Implant, Fixture Osseospeed will be placed in the posterior upper jaw of 20 eligible subjects.|DEVICE: Placement of dental implant|DEVICE: dental implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial of Standard Chemotherapy With Metformin (vs Placebo) in Women With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypertension Prevention in Pre-Hypertensive Individuals
Status: COMPLETED
Conditions: Pre-hypertension|Hypertension|Cardiovascular Disease
Interventions: DRUG: Chlorthalidone plus amiloride|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study With Aliskiren Alone or in Combination Therapy With Diuretic Hctz in Venezuelan Hypertensive Patients.
Status: COMPLETED
Conditions: High Blood Pressure
Interventions: DRUG: Aliskiren and HCTZ
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erlotinib (Tarceva (Trademark), OSI-774) in Treating Patients With Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Advanced Non Small Cell Lung Cancer|Failed Prior Chemotherapy
Interventions: DRUG: Tarceva (Trademark) (erlotinib HCl, OSI-774)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MK2206 in Combination With Anastrozole, Fulvestrant, or Anastrozole and Fulvestrant in Treating Postmenopausal Women With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Estrogen Receptor Positive|Invasive Breast Carcinoma|Recurrent Breast Carcinoma|Stage IV Breast Cancer AJCC v6 and v7
Interventions: DRUG: Akt Inhibitor MK2206|DRUG: Anastrozole|DRUG: Fulvestrant|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individual Dosage Selection of Irinotecan (CPT-11) Based on UGT1A1 Genotype in Metastatic Colorectal Cancer Patients
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Irinotecan Injection [Camptosar]|DRUG: 5-fluorouracil|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of the Third Dose Immunization Schedule of COVID-19 Inactivated Vaccine, (Vero Cells) in Adults Aged 18 Years and Above
Status: UNKNOWN
Conditions: SARS-CoV2 Infection
Interventions: BIOLOGICAL: SARS-CoV-2 Vaccine, Inactivated (Vero Cell)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparative Evaluation of the Results of Facet Joint Injections
Status: COMPLETED
Conditions: Low Back Pain, Mechanical|Facet Syndrome of Lumbar Spine
Interventions: PROCEDURE: Intra-articular injection to lumbar facet joint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study (Candesartan 16 mg and Amlodipine 5 mg) - B
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: CKD-330 16/5mg - B|DRUG: Candesartan 16mg and Amlodipine 5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT