pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Platform Study of Novel Agents in Combination With Radiotherapy in NSCLC
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: RADIATION: Radiotherapy|DRUG: Olaparib Oral Tablet [Lynparza]|DRUG: AZD1390|DRUG: Ceralasertib|DRUG: AZD5305|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography (PET) Study With [11C]AZ12713580 to Determine Central mGluR5 Receptor Occupancy of AZD2066
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD2066|DRUG: radioligand [11C] AZ12713580
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Grifola Frondosa (Maitake), Azacitidine, and Lenalidomide
Status: TERMINATED
Conditions: Advanced Cancers
Interventions: DRUG: Azacitidine|DRUG: Lenalidomide|DRUG: Grifola Frondosa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dietary Protein and Energy Restriction in the Improvement of Insulin Resistance in Subjects With Obesity
Status: COMPLETED
Conditions: Obesity|Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: Normoprotein diet with animal protein|DIETARY_SUPPLEMENT: Normoprotein diet with vegetable protein|DIETARY_SUPPLEMENT: High-protein diet with animal protein|DIETARY_SUPPLEMENT: High-protein diet with vegetable protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of VX-809 in Cystic Fibrosis Subjects With the ∆F508-CFTR Gene Mutation
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: VX-809|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ToGA Study - A Study of Herceptin (Trastuzumab) in Combination With Chemotherapy Compared With Chemotherapy Alone in Patients With HER2-Positive Advanced Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: Trastuzumab|DRUG: Fluorouracil|DRUG: Cisplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Metabolic Syndrome Among Leukemia Survivors: Physiopathological Analysis
Status: UNKNOWN
Conditions: Metabolic Syndrome X
Interventions: OTHER: Adipose tissu repartition|OTHER: Visceral and liver adipose tissue repartition|OTHER: Preadipocyte quantification and adipose tissue inflamation|OTHER: Inflamation blood markers quantification
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Post Market Clinical Follow-up Investigation to Evaluate Performance and Safety on Pressure Ulcers, PU, When Using Exufiber as Intended
Status: COMPLETED
Conditions: Pressure Ulcers
Interventions: DEVICE: Fast Gelling Dressing (Exufiber)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GRAVITAS-301: A Study of Itacitinib or Placebo in Combination With Corticosteroids for Treatment of Acute Graft-Versus-Host Disease
Status: COMPLETED
Conditions: Graft-versus-host Disease (GVHD)
Interventions: DRUG: Itacitinib|DRUG: Placebo|DRUG: Prednisone|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Octreotide Treatment to Improve Nutritional Recovery After Surgery for Patients With Esophageal or Gastric Cancer
Status: RECRUITING
Conditions: Esophageal Cancer|Gastric Cancer
Interventions: DRUG: Octreotide Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Olaparib and Temozolomide in Patients With Recurrent Small Cell Lung Cancer Following Failure of Prior Chemotherapy
Status: UNKNOWN
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Olaparib|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of 1 g Vs 2 g Per Hour Intravenous Maintenance Dose of MgSO4 in Women With Severe Pre-eclampsia
Status: COMPLETED
Conditions: Severe Preeclampsia
Interventions: DRUG: Magnesium Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 2nd-line Treatment of Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: bevacizumab, oxaliplatin and 5FU combination|DRUG: Bevacizumab, oxaliplatin and raltitrexed combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MK-1942/Donepezil Interactions in Participants With Alzheimer's Disease (MK-1942-005)
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: MK-1942|DRUG: Donepezil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I, Observer-Blind, Placebo-Controlled Study of the Chiron Vaccine HIV p24/MF59 Administered to Healthy HIV-Seronegative Adults
Status: COMPLETED
Conditions: HIV Infections|HIV Seronegativity
Interventions: BIOLOGICAL: HIV p24/MF59 Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: PREVENTION
Clinical trial: Outcome Study of the Pipeline Embolization Device With Vantage Technology in Unruptured Aneurysms
Status: ACTIVE_NOT_RECRUITING
Conditions: Brain Aneurysm|Intracranial Hemorrhages|Stroke
Interventions: DEVICE: Pipeline Embolization Device with Vantage Technology
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Belly Fat Study: Nutritional Intervention to Improve Metabolic Health in Subjects With Increased Abdominal Adiposity
Status: COMPLETED
Conditions: Abdominal Obesity|Liver Fat
Interventions: OTHER: Dietary advice, Western|OTHER: Dietary advice, Targeted
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Low-energy Laser Applications in Patients With Juvenile Idiopathic Arthritis
Status: COMPLETED
Conditions: Juvenile Idiopathic Arthritis|Rheumatic Diseases|Chronic Knee Pain|Fatigue|Muscle Weakness|Polyarticular JCA
Interventions: OTHER: Physical Exercise|OTHER: Physical Exercise plus Low-energy Laser Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Application of Thermal Stimulation on Functional Recovery of Stroke Patients
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Noxious TS|OTHER: Innocuous TS|OTHER: High Frequency of Noxious TS|OTHER: Low Frequency of Noxious TS|OTHER: High Intensity of Noxious TS|OTHER: Low Intensity of Noxious TS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Individualized Dietary Intervention in Breastfeeding Women: Body Weight and Vitamin A Stores
Status: COMPLETED
Conditions: Overweight and Obesity|Vitamin A Deficiency|Dietary Modification|Breastfeeding
Interventions: BEHAVIORAL: Intervention-Nutrition guidelines|BEHAVIORAL: Nutrition guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Walnuts, Walnut-Oil, Almonds and Fish Oils on Glucose Homeostasis in Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: walnuts|DIETARY_SUPPLEMENT: almonds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decitabine Maintenance for Acute Myelogenous Leukemia (AML) and Myelodysplastic Syndrome (MDS) Post Transplant
Status: COMPLETED
Conditions: Leukemia, Myeloid, Acute|Myelodysplastic Syndromes
Interventions: DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY2605541 and Glargine in Participants With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: BIOLOGICAL: LY2605541|BIOLOGICAL: Insulin Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Trial of TCM Collaborative Care Model in Axial Spondyloarthritis
Status: RECRUITING
Conditions: Axial Spondyloarthritis
Interventions: OTHER: TCM physician involved collaborative care model (TCMCMC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of ß-glucan Supplementation on Subjective Appetite and Gastrointestinal Appetite Hormones.
Status: RECRUITING
Conditions: Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: β-glucan|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Home-based Psychoeducation for Older Adults With Frailty: A Randomised Controlled Trial
Status: RECRUITING
Conditions: Frailty|Well-Being, Psychological
Interventions: OTHER: Psychoeducation|OTHER: Attention control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Ondansetron for the Treatment of IBS With Diarrhoea (IBS-D)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Diarrhoea
Interventions: DRUG: Ondansetron|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial of Low-Dose Bevacizumab vs Laser for Type 1 ROP
Status: TERMINATED
Conditions: Retinopathy of Prematurity
Interventions: DRUG: Bevacizumab|PROCEDURE: Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Corneal Confocal Microscopy to Detect Diabetic Neuropathy in Children
Status: COMPLETED
Conditions: Type 1 Diabetes|Neuropathy|Retinopathy
Interventions: PROCEDURE: Corneal Confocal Microscopy|PROCEDURE: Nerve Conduction Studies|PROCEDURE: Quantitative sensory testing|PROCEDURE: Neuropathy Symptom Score|PROCEDURE: Clinical nerve examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Sinusitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Sinus Infection|Acute Sinusitis
Interventions: DRUG: Amoxicillin/clavulanate|DRUG: Placebo antibiotic|DRUG: Budesonide nasal spray|OTHER: C-reactive protein|OTHER: Mid-turbinate swab (optional)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Anthriscus Sylvestris Leaves on Mild Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis|Articular Cartilage|Functional Food
Interventions: DIETARY_SUPPLEMENT: Aqueous extract of A. sylvestris leaves|DIETARY_SUPPLEMENT: microcrystalline cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Impact of Renal Function on the Pharmacokinetics of SIKLOS ® (DARH)
Status: COMPLETED
Conditions: Sickle Cell Disease|Renal Function Disorder
Interventions: DRUG: Siklos
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effects of Different Physiotherapy Approaches in Stable COPD Patients.
Status: UNKNOWN
Conditions: COPD
Interventions: OTHER: intervention group 1|OTHER: intervention group 2|OTHER: intervention group 3|OTHER: intervention group 4|OTHER: Pulmonary Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Scottish Fruit Study
Status: COMPLETED
Conditions: Postprandial Hypoglycemia|Age-Related Memory Disorders
Interventions: DIETARY_SUPPLEMENT: Honeyberry|DIETARY_SUPPLEMENT: Cherry|DIETARY_SUPPLEMENT: Raspberry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase II Trial of Lurbinectedin Combined With Avelumab as Switch Maintenance Firstline Therapy
Status: WITHDRAWN
Conditions: Metastatic Cancer|Urothelial Carcinoma
Interventions: DRUG: avelumab (PD-L1 inhibitor immunotherapy) + lurbinectedin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Pharmacogenomics of Cladribine Based Salvage Chemotherapy in Patients With Relapse/Refractory and Secondary Acute Myeloid Leukemia (AML) and High Risk Myelodysplastic Syndrome (MDS)
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: Cladribine, Cytarabine, Mitoxantrone, G-CSF (CLAG-M) regimen|DRUG: Cladribine and Cytarabine (CLLDAC) Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Ablation Versus I-131 for Solitary Autonomous Thyroid Nodules
Status: RECRUITING
Conditions: Thyroid Nodule, Toxic or With Hyperthyroidism|Autonomous Thyroid Function|Thyroid Nodule; Hyperthyroidism|Radiofrequency Ablation|Iodine Hyperthyroidism|Iodine Adverse Reaction
Interventions: DEVICE: Radiofrequency ablation|DRUG: Radioactive iodine|DRUG: Radioactive iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 'SOURCE - LUNG' Stereotactic Ablative Radiation Therapy Of UltRaCEntral LUNG Tumours (SOURCE Lung)
Status: RECRUITING
Conditions: NSCLC/Oligometastatic Cancer (Single Lung Lesion)
Interventions: RADIATION: Image-Guided Stereotactic Ablative Radiotherapy (IG-SABR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Preliminary Pharmacodynamics of QBW251 in Healthy Subjects and Cystic Fibrosis Patients
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DRUG: Placebo|DRUG: QBW251
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Transcranial Direct-current Stimulation Therapy on Primary Chronic Insomnia Patients
Status: COMPLETED
Conditions: Primary Insomnia
Interventions: DEVICE: transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Argatroban for Preventing Occlusion and Restenosis After Intracranial and Extracranial Artery Stenting
Status: COMPLETED
Conditions: CVD
Interventions: DRUG: Argatroban|DRUG: non-argatroban treated group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ezetimibe Plus (+) Simvastatin Versus Atorvastatin Comparative Study (0653A-092)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: ezetimibe (+) simvastatin|DRUG: atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety Study of PT010 in Healthy Subjects
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: PT010|DRUG: PT009|DRUG: Symbicort Turbohaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Proof of Concept Study to Evaluate the Antiviral Activity, Safety, and Pharmacokinetics of the CCR5 Antagonist TBR 652 in HIV 1-Infected, Antiretroviral Treatment-Experienced, CCR5 Antagonist-Naïve Patients
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: TBR-652|DRUG: TBR-652 Matching Placebo|DRUG: TBR-652 50 mg|DRUG: TBR-652 75 mg|DRUG: TBR-652 100 mg|DRUG: TBR-652 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Comparison of Effect of Four Different Treatment Protocols on IVF Outcomes in Poor Responders Undergoing in Vitro Fertilization.
Status: UNKNOWN
Conditions: Poor Responders Undergoing IVF
Interventions: DRUG: GnrH Antagonist/letrozole protocol (Cetrotide; serono + Femara; Novartis Pharma AG)|DRUG: microdose flare-up protocol (Lucrin; Abbott + Gonal F, Serono)|DRUG: Antagonist/clomiphene protocol (Cetrotide; serono + Klomen, Kocak pharma)|DRUG: GnRH antagonist protocol (Cetrotide, Serono)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Adjunct Phentermine + Topiramate After Bariatric Surgery in 12-24 Year Olds
Status: COMPLETED
Conditions: Obesity, Morbid|Bariatric Surgery|Adolescent|Young Adult|Drug Therapy
Interventions: DRUG: Phentermine|DRUG: Immediate Release Topiramate|DRUG: Placebo for Phentermine|DRUG: Placebo for Immediate Release Topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electrocautery Versus Scalpel for Skin Incisions
Status: COMPLETED
Conditions: Wound Complication|Surgical Wound Infection|Post-operative Pain
Interventions: PROCEDURE: Electrocautery|PROCEDURE: Scalpel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study on the Treatment of Cerebral Small Vascular Disease
Status: UNKNOWN
Conditions: Cerebral Small Vessel Diseases
Interventions: DRUG: Butylphthalide Soft Capsules|DRUG: placebo Soft Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of RBCs Derived From Mirasol-treated Whole Blood in Patients Requiring Chronic Transfusion (PRAISE)
Status: TERMINATED
Conditions: Transfusion Dependent Thalassemia
Interventions: DEVICE: Mirasol Red Blood Cells (MIR RBCs)|DEVICE: Reference Red Blood Cells (REF RBCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Brief High-intensity Interval Training Mitigate the Adverse Consequences of High-fat Overfeeding?
Status: TERMINATED
Conditions: Insulin Resistance
Interventions: OTHER: Wingate HIT|OTHER: Modified HIT|OTHER: High-fat overfeeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Defining a Technique for the Use of Cryogenic Catheters for Biopsy and Ablation for the Diagnostic and Treatment of Pulmonary Lesions: An Ex-Vivo Human Lung Model Study.
Status: RECRUITING
Conditions: Lung Diseases
Interventions: DIAGNOSTIC_TEST: Cryo Ex Vivo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Home-based Video, Paper/Print Checklist and Professional Home Assessment in Detection of Fall Hazards at Home
Status: COMPLETED
Conditions: Identification of Home Fall Hazards
Interventions: BEHAVIORAL: Video based/Therapists' rating of comprehensive-home-fall-hazard-checklist (vt-CHFHC)|BEHAVIORAL: Paper based/Patient self-rating of comprehensive-home-fall-hazard-checklist (pp-CHFHC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Cardiovascular Outcomes of Pioglitazone and Metformin in Type 2 Diabetes Patients
Status: WITHDRAWN
Conditions: Type 2 Diabetes
Interventions: DRUG: Pioglitazone vs Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Single-Arm, Open-Label, Multicenter Clinical Trial With Nivolumab (BMS-936558) for Subjects With Histologically Confirmed Stage III (Unresectable) or Stage IV Melanoma Progressing Post Prior Treatment Containing an Anti-CTLA4 Monoclonal Antibody (CheckMate 172)
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Nivolumab (BMS-936558)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Okara and Bio-okara Food Product on Gut and Glycaemic Health in Middle-aged and Older Adults in Singapore
Status: UNKNOWN
Conditions: Microbiota|Gastrointestinal Microbiome|Blood Glucose|Aging
Interventions: DIETARY_SUPPLEMENT: Okara biscuits|DIETARY_SUPPLEMENT: Bio-okara biscuits|DIETARY_SUPPLEMENT: Control biscuits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Extensive Mesenteric Excision (EME) Versus Local Mesenteric Excision (LME) for Crohn's Disease
Status: COMPLETED
Conditions: Postoperative Disease Recurrence|Crohns Disease
Interventions: PROCEDURE: mesenteric excision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Endoscopic Submucosal Dissection (ESD) Efficacy
Status: COMPLETED
Conditions: Colorectal Neoplasms|Endoscopic Submucosal Dissection
Interventions: PROCEDURE: Endoscopic submucosal dissection (ESD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relationships Between OLST, GMFM and Pedobarographic Values in CP
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: DIAGNOSTIC_TEST: one leg standing test, gross motor function measurement, pedobarographic measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Right Versus Left Apical Transvenous Pacing for Patients With Preserved Left Ventricular Systolic Function Study
Status: TERMINATED
Conditions: Bradyarrhythmia
Interventions: DEVICE: Implantation procedure for a St-Jude Medical pacemaker system with right ventricular apex pacing|DEVICE: Implantation procedure for a St-Jude Medical pacemaker system with left ventricular apex pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pelvic Radiotherapy With Concurrent Neoadjuvant FOLFOX for Patients With Newly Diagnosed Rectal Adenocarcinoma
Status: TERMINATED
Conditions: Rectal Adenocarcinoma
Interventions: DRUG: FOLFOX {5-fluorouracil (5-FU), leucovorin, and oxaliplatin}|RADIATION: Low dose fractionated radiation therapy (LDFRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Surgical Epilepsy Trial for Temporal Lobe Epilepsy
Status: RECRUITING
Conditions: Temporal Lobe Epilepsy|Open Surgery|Minimally Invasive Surgery
Interventions: PROCEDURE: Functional anterior temporal lobectomy (FATL)|PROCEDURE: Anterior temporal lobectomy (ATL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glycogen Storage Disease Breath Test Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Patient Compliance|Healthy
Interventions: DIETARY_SUPPLEMENT: Glucose intake|DIETARY_SUPPLEMENT: Carbohydrates intake
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Open-label Extension Study of GB002 in Adult Subjects With Pulmonary Arterial Hypertension (PAH)
Status: RECRUITING
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: GB002 (seralutinib)|DEVICE: Generic Dry Powder Inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preterm Infant Oral Motor Intervention (PIOMI)
Status: NOT_YET_RECRUITING
Conditions: Preterm Birth|Feeding Behavior
Interventions: OTHER: PIOMI|OTHER: PIOMI+kangaroo care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Radiofrequency Ablation: Treatment for Posterior Element Pain From Vertebral Compression Fractures
Status: TERMINATED
Conditions: Vertebral Compression Fracture|Facet Joint Pain
Interventions: PROCEDURE: Radiofrequency ablation of the medial branch nerves|DRUG: Non-steroidal anti-inflammatory drugs|DRUG: Bisphosphonates|DRUG: Acetaminophen|BEHAVIORAL: Physical therapy|DRUG: Opioids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Acupuncture in the Treatment of Hot Flashes in Patients With Hormone Receptor-positive Breast Cancer.
Status: NOT_YET_RECRUITING
Conditions: Hot Flashes|Breast Cancer|Acupuncture
Interventions: OTHER: Acupuncture treatment|OTHER: Sham acupuncture treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Senofilcon A Contact Lenses Using a Novel Manufacturing Technology to Evaluate Overall Visual Acuity.
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: senofilcon A contact lenses made with a novel manufacturing technology|DEVICE: senofilcon A contact lenses made with the current manufacturing technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Specificities of the Eccentric Exercise: Energy Expenditure and Nature of Oxidized Substrates
Status: UNKNOWN
Conditions: Overweight|Healthy|Men
Interventions: OTHER: Test of effort on cycle on concentric or excentric mode|OTHER: Kinetics on concentric or excentric mode during test of effort
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Skin Closure With Tissue Adhesives vs. Subcuticular Suture After Robotic Urogynecologic Procedures
Status: COMPLETED
Conditions: Surgical Wound|Tissue Adhesion
Interventions: PROCEDURE: Subcuticular Skin Closure|DEVICE: Tissue Adhesives
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HepB-CpG Series for Healthcare Workers Who Are Hepatitis B Vaccine Nonresponders
Status: COMPLETED
Conditions: Healthcare Worker, Hepatitis B Vaccine, Nonresponder
Interventions: BIOLOGICAL: Recombinant hepatitis B vaccine with CpG adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase I/Ib Study of AZD9150 (ISIS-STAT3Rx) in Patients With Advanced/Metastatic Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Advanced Adult Hepatocellular Carcinoma|Hepatocellular Carcinoma Metastatic
Interventions: DRUG: AZD9150
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of AVE5026 at Weight-adjusted Doses in Children With a Central Venous Line
Status: TERMINATED
Conditions: Thrombosis Prophylaxis (Risk of Thrombosis Due to Central Venous Line (CVL)
Interventions: DRUG: Semuloparin sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Follow-up Safety and Efficacy Evaluation on Subjects Who Completed Phase I Clinical Trial
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: BIOLOGICAL: SMUP-IA-01(low-dose)|BIOLOGICAL: SMUP-IA-01(mid-dose)|BIOLOGICAL: SMUP-IA-01(high-dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial Into the Efficacy of rTMS Treatment for Treating Anorexia Nervosa and Bulimia Nervosa
Status: WITHDRAWN
Conditions: Eating Disorders|Anorexia Nervosa|Bulimia Nervosa
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation|DEVICE: Sham Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of High Carbohydrate vs. Low Carbohydrate Diet in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus|Diabetes Mellitus, Type 2
Interventions: OTHER: glycogen loading|OTHER: No Glycogen Loading
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Method to Optimize Mecanical In-exsufflation in Neuromuscular Diseases
Status: COMPLETED
Conditions: Neuromuscular Disease
Interventions: DEVICE: Cough Assist® (JH Emerson Compagny, Cambridge, MA, USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SMR Stemless Reverse vs SMR Reverse Shoulder System
Status: RECRUITING
Conditions: Arthroplasty, Replacement
Interventions: DEVICE: Investigational Arm: SMR Stemless Reverse|DEVICE: Control Arm: SMR Reverse Shoulder System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ABT-869 in Combination With Tarceva in Subjects With Solid Tumors
Status: WITHDRAWN
Conditions: Solid Tumors
Interventions: DRUG: ABT-869|DRUG: Tarceva
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Indacaterol Delivered Via a Single Dose Dry Powder Inhaler (SDDPI) in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|COPD|Lung Diseases, Obstructive
Interventions: DRUG: indacaterol maleate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Multi-level Life-span Characterization of Adult-depression and Effects of Medication and Exercise
Status: COMPLETED
Conditions: Depression|Depressive Disorder, Major|Depressive Disorder|Unipolar Depression|Major Depressive Disorder
Interventions: DRUG: Venlafaxine XR|OTHER: Aerobic Exercise|DRUG: Lorazepam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetic Seizure Therapy vs. Electroconvulsive Therapy for Bipolar Mania
Status: WITHDRAWN
Conditions: Bipolar Disorder, Manic
Interventions: DEVICE: Magpro X100 + Option|DEVICE: ThymatronSystem Ⅳ Electroconvulsive System|OTHER: treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Systematic Symptom Identification With Disease Specific PROM to Assess Symptoms of Chronic GVHD in Outpatient Care in Patients Post HSCT
Status: COMPLETED
Conditions: GVHD, Chronic|Hematological Malignancy
Interventions: BEHAVIORAL: Lee Symptom Scala
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Administration of Ropivacaine by Bi-laterosternal Multiperforated Catheters Placed Before a Sternotomy for Cardiac Surgery
Status: COMPLETED
Conditions: Scheduled Cardiac Surgery|Age Under 85 Years
Interventions: DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validity of Fluorescence-Based Devices Versus Visual-Tactile Method in Detection of Secondary Caries Around Resin Composite Restorations: Invivo Diagnostic Accuracy Study
Status: UNKNOWN
Conditions: Secondary Caries Around Resin Composite Restorations
Interventions: DIAGNOSTIC_TEST: Light induced fluorescence intraoral camera|DIAGNOSTIC_TEST: Laser-induced fluorescence device|DIAGNOSTIC_TEST: Visual-tactile assessment method according to FDI criteria
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety Study of Different Doses of hA20 (Veltuzumab) in CD20+ Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma|Lymphoma, Diffuse|Lymphoma, Diffuse, Mixed Lymphocytic-Histiocytic
Interventions: DRUG: veltuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LPN in Patients With High-complex Renal Tumors
Status: COMPLETED
Conditions: Renal Cancer|Renal Neoplasm|Renal Cell Carcinoma|Surgery|Oncology|Kidney Ischemia|Kidney Injury|Urologic Neoplasms|Urologic Cancer|Kidney Neoplasms
Interventions: PROCEDURE: laparoscopic partial nephrectomy|PROCEDURE: Laparoscopic radical nephrectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Head-of-Bed on Intracranial Pressure
Status: RECRUITING
Conditions: Subarachnoid Hemorrhage, Aneurysmal
Interventions: OTHER: Supine|OTHER: Semi-Recumbent|OTHER: Semi-Recumbent with Legs Flexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: he Effect of Motivational Statements Applied to Nurses in the Emergency Department on Job Satisfaction, Compassion Fatigue and Communication Skills During the Pandemic Period: A Randomized Controlled Study
Status: COMPLETED
Conditions: Satisfaction|Compassion Fatigue|Communication, Social
Interventions: OTHER: Motivation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immune Effect of Dexmedetomidine in Patients Undergoing to Spinal Fusion
Status: UNKNOWN
Conditions: Spine; Arthrosis|Spondylolysis|Spondylolysis, Multiple Sites in Spine|Spondylolisthesis
Interventions: DRUG: Dexmedetomidine intervention|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Intermittent bolus epidural morphine|DRUG: continuous epidural morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CRANIO-CAUDAL AND LATERAL APPROACH FOR RECURRENT LARYNGEAL NERVE
Status: COMPLETED
Conditions: Recurrent Laryngeal Nerve Injuries
Interventions: PROCEDURE: Lateral approach|PROCEDURE: Cranio-caudal approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Utilizing Glycaemic Index: An Investigation of the Glycaemia and Cognition in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Cognitive Impairment
Interventions: DIETARY_SUPPLEMENT: Low Glycaemic Diet|DIETARY_SUPPLEMENT: High Glycaemic Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety Study of Everolimus Plus Reduced Cyclosporine Versus Mycophenolic Acid Plus Cyclosporine in Kidney Transplant Recipients
Status: COMPLETED
Conditions: Kidney Transplantation|Graft Rejection
Interventions: DRUG: Everolimus|DRUG: Mycophenolic Acid (MPA)|DRUG: Cyclosporine A (CsA)|DRUG: Basiliximab|DRUG: Corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep and Ventricular Arrhythmias Study
Status: COMPLETED
Conditions: Cardiac Arrhythmia|Implantable Defibrillator User|Insomnia
Interventions: BEHAVIORAL: CBT for Insomnia in ICD Patients (CBT-I-ICD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SIR-Spheres® 90Y Microspheres Treatment of Uveal Melanoma Metastasized to Liver
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage IV Uveal Melanoma
Interventions: DEVICE: Sir-Spheres®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Impact of Pomegranate Polyphenols Following Ischemic Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DIETARY_SUPPLEMENT: POMx|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LJPC-401 for the Treatment of Iron Overload in Adult Patients With Hereditary Hemochromatosis
Status: COMPLETED
Conditions: Hereditary Hemochromatosis
Interventions: DRUG: LJPC-401|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Therapy for Recurrent Depression
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Continuation phase cognitive therapy|DRUG: Continuation phase fluoxetine|OTHER: Continuation phase pill placebo|BEHAVIORAL: Acute phase cognitive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Live-Attenuated Human Parainfluenza Virus Type 3 Vectored Vaccine Candidate Expressing Ebolavirus Zaire Glycoprotein as the Sole Envelope Glycoprotein
Status: SUSPENDED
Conditions: Ebola Virus Disease
Interventions: BIOLOGICAL: HPIV3/ΔHNF/EbovZ GP vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Screening for Deep Vein Thrombosis in Intensive Care
Status: RECRUITING
Conditions: Deep Vein Thrombosis
Interventions: DIAGNOSTIC_TEST: Ultrasound screening for lower limbs DVT|DIAGNOSTIC_TEST: Standard-of-care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Lidocaine and Magnesium and Ketamine in Gynecological Surgery
Status: RECRUITING
Conditions: Pain, Postoperative|Pain, Acute|Pain, Chronic|Pain, Neuropathic|Lidocaine|Ketamine|Magnesium|Central Nervous System Depressants|Analgesics|Neurotransmitter Agents|Analgesics, Non-narcotic
Interventions: DRUG: lidocaine-magnesium infusion|DRUG: lidocaine-ketamine infusion|DRUG: lidocaine infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TGR-1202 and Ibrutinib in Treating Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Status: COMPLETED
Conditions: Recurrent Diffuse Large B-Cell Lymphoma|Refractory Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Ibrutinib|OTHER: Laboratory Biomarker Analysis|DRUG: PI3K-delta Inhibitor TGR-1202
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Assess the Effect of High Dose N-acetylcysteine (NAC) in Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: N-acetylcysteine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Teva Asthma Predictive Analytics Study
Status: COMPLETED
Conditions: Asthma
Interventions: COMBINATION_PRODUCT: AirDuo Digihaler|COMBINATION_PRODUCT: ProAir Digihaler
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Samatasvir (IDX719) in Combinations With Simeprevir and/or TMC647055/Ritonavir With or Without Ribavirin for 12 Weeks in Participants With Chronic Hepatitis C Infection (MK-1894-005)
Status: COMPLETED
Conditions: Chronic Hepatitis C Virus
Interventions: DRUG: Samatasvir|DRUG: Simeprevir|DRUG: Ribavirin (RBV)|DRUG: TMC647055|DRUG: Ritonavir (RTV)|BIOLOGICAL: Pegylated interferon (Peg-IFN)|OTHER: Samatasvir matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Risk Reduction Program for Women Having High Risk of Breast Cancer
Status: COMPLETED
Conditions: Cancer Screening|Early Detection of Cancer|Breast Cancer|Preventive Health Care|Health Behavior
Interventions: BEHAVIORAL: Breast Cancer Risk Reduction Program (BrCaRRP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Plastic Stenting Versus Retrievable Metallic Stenting for Biliary Anastomotic Stricture After Liver Transplantation
Status: UNKNOWN
Conditions: Biliary Anastomotic Stenosis
Interventions: DEVICE: Retrievable metallic stenting|DEVICE: Plastic stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neurocognitive Function Improvement After Switching From Efavirenz to Rilpivirine
Status: UNKNOWN
Conditions: HIV-1-infection|Neurocognitive Dysfunction
Interventions: DRUG: Rilpivirine 25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Absorption of GT267-004 in Patients With Clostridium Difficile-Associated Diarrhea
Status: COMPLETED
Conditions: Pseudomembranous Colitis|Clostridium Difficile Diarrhea|Antibiotic-Associated Diarrhea
Interventions: DRUG: tolevamer potassium-sodium (GT267-004)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Silver Nanoparticle Gel Versus a Common Antibacterial Hand Gel
Status: UNKNOWN
Conditions: Normal Subjects
Interventions: DRUG: nano-silver gel exposed|DRUG: alcohol-based hand gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: The Effect of Traditional Chinese Medicine on Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: VGH-BPH1|DRUG: Placebo (Corn starch pill manufactured to mimic VGH-BPH1)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Glycyrrhizin as Intracanal Medication in Root Canal Disinfection and Inflammatory Cytokines
Status: RECRUITING
Conditions: Intracanal Medication
Interventions: DRUG: Calcium Hydroxide|DRUG: Leddermix|DRUG: Glycirrhizin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Music Therapy for Older Adults With Cognitive Decline Living in Care Homes
Status: COMPLETED
Conditions: Cognitive Impairment|Cognitive Decline
Interventions: BEHAVIORAL: Music Therapy|BEHAVIORAL: Storytelling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Recovery Effect of Sugammadex Measured by Bispectral and Neurosense Indices
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Sugammadex - Nacl 9/00|DRUG: Nacl 9/00 - sugammadex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT