pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Preoperative Assessment and Individualized Operation Optimization of Acute Ruptured Cerebral Aneurysms
Status: UNKNOWN
Conditions: Printing, Three-Dimensional, Simulation Training
Interventions: PROCEDURE: Printing, Three-Dimensional
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of "Snow-plow"Technique Versus Bulk Fill Technique in Restorations of Class II Cavities
Status: COMPLETED
Conditions: Class II Dental Caries
Interventions: PROCEDURE: "Snow-plow" technique|PROCEDURE: Bulk fill technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Bladder Training Improve the Efficacy of Nerve Stimulation in Women With Refractory Overactive Bladders
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: BEHAVIORAL: Bladder Training (BT)|DEVICE: Percutaneous Tibial Nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conscious Sedation Efficacy of the MKO Melt (Midazolam, Ketamine, Ondansetron)
Status: COMPLETED
Conditions: Cataract
Interventions: DRUG: Diazepam|DRUG: Tramadol|DRUG: Ondansetron|DRUG: MKO melt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment of Complementary Treatment With Qishen Yiqi Dripping Pills on Ischemic Heart Failure
Status: UNKNOWN
Conditions: Ischemic Heart Failure
Interventions: DRUG: Qishen Yiqi Dripping Pills|DRUG: Qishen Yiqi dripping pills dummy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety Study With Alfuzosin in Children and Adolescents With Elevated Detrusor Leak Point Pressure of Neuropathic Etiology
Status: COMPLETED
Conditions: Urinary Bladder Neurogenic
Interventions: DRUG: alfuzosin (SL770499)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Pegteograstim in Korean Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Pegfilgrastim|DRUG: Doxorubicin/Cyclophosphamide(AC) treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mental Stress Reduction in Defibrillator Patients
Status: TERMINATED
Conditions: Cardiomyopathy, Dilated|Arrhythmia|Anger|Stress
Interventions: BEHAVIORAL: Cognitive Behavioral Stress Management (CBSM)|OTHER: Patient Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Hydromorphone for Cesarean Section
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: intrathecal hydromorphone (IT hydromorphone)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Parathyroid Hormone (PTH) Attenuation Trial in Hemodialysis-2
Status: ACTIVE_NOT_RECRUITING
Conditions: Secondary Hyperparathyroidism|End Stage Kidney Disease
Interventions: DRUG: PLS240|DRUG: Placebo|DRUG: Open-Label Extension PLS240
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of a Educational Internet-based Intervention in Chronic Low Back Pain Patients: A Mixed Methods Approach
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Educational intervention|OTHER: Normal care by GP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema
Status: RECRUITING
Conditions: Emphysema, Pulmonary|Emphysema or COPD
Interventions: DEVICE: AeriSeal System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a High Intensity Resistance Training in Muscular Strength, Agility, and Body Composition of Anorexia Nervosa Restricting Type Patients
Status: COMPLETED
Conditions: Anorexia Nervosa Restricting Type
Interventions: BEHAVIORAL: High-Intensity Resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Tesamorelin in Chronic Obstructive Pulmonary Disease (COPD) Subjects With Muscle Wasting
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Tesamorelin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nails and Teeth as Biomarkers of Fluoride Exposure
Status: COMPLETED
Conditions: Fluorosis, Dental
Interventions: DEVICE: Biodent Toothpaste (Ilirija d.d., Ljubljana, Slovenia)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Positron Emission Tomography (PET) Study With (11C)Flumazenil to Determine Central GABAA Receptor Occupancy of AZD7325
Status: COMPLETED
Conditions: Anxiety
Interventions: DRUG: AZD7325|DRUG: Radioligand (11C) flumazenil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Manual Versus Oscillating-rotating Toothbrushes After Root Coverage Procedure
Status: COMPLETED
Conditions: Gingival Recession
Interventions: DEVICE: Manual Toothbrush|DEVICE: Oscillating-rotating toothbrush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Melatonin, Soluble Urokinase-type Plasminogen Activator Receptor, and Orosomucoid 2 Levels in PPROM
Status: UNKNOWN
Conditions: Preterm Premature Rupture of Membranes
Interventions: OTHER: Obstetric ultrasound and fetal-maternal assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SBD121, a Synbiotic Medical Food for RA Management
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: OTHER: SBD121|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Peri-Operative Lidocane, Ketamine, or Lidocane and Ketamine Combination, Infusion for Patients Undergoing Spine Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Lidocaine|DRUG: Ketamine|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rituximab in Treating Patients With Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma|Hodgkin Lymphoma (Category)|Nodular Lymphocyte Predominant Hodgkin Lymphoma
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recovery Management Checkups for Opioid Use Disorder Experiment
Status: RECRUITING
Conditions: Opioid-use Disorder
Interventions: COMBINATION_PRODUCT: Recovery Management Checkups (RMC)|COMBINATION_PRODUCT: RMC-Adaptive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of B-CLL With Human IL-2 and CD40 Ligand and Plasmid Gene Modified Autologous Tumor Cells
Status: COMPLETED
Conditions: Leukemia|Leukemia, B-Cell, Chronic
Interventions: BIOLOGICAL: Dose Level 1|BIOLOGICAL: Dose Level 2|BIOLOGICAL: Dose Level 2- Fixed Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Pharmacodynamics Trial With Linagliptin (BI 1356) 5mg in African American Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: linagliptin QD (once daily) for 7 days
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fight INflammation to Improve Outcome After Aneurysmal Subarachnoid HEmorRhage
Status: RECRUITING
Conditions: Aneurysmal Subarachnoid Hemorrhage
Interventions: DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Initiating Transdermal Estradiol Therapy in Turner's Syndrome
Status: TERMINATED
Conditions: Turner's Syndrome
Interventions: DRUG: Norditropin, Menostar 14mcg patch, Vivelle dot 25mcg patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: 68Ga-PSMA PET Imaging of Upper Metastatic Gastric Cancers to Determine Eligibility to Endoradiotherapy
Status: RECRUITING
Conditions: Upper Digestive Tract Cancer
Interventions: BIOLOGICAL: Radiopharmaceutical 68Ga-PSMA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Psychoneuroimmunology Therapy in Uncontrolled Diabetic Patients: A Quasi-experimental Study
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: psychoneuroimmune therapy|DRUG: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Observational Study on the Efficacy and Safety of NovoSeven® During "Real-life" Usage in Germany
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Congenital FVII Deficiency|Glanzmann's Disease|Acquired Bleeding Disorder|Acquired Haemophilia
Interventions: DRUG: eptacog alfa (activated)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Determination of Minimum Effective Volume of Local Anesthetic in Patients Undergoing Ultrasound-Guided Infraclavicular Approach for Brachial Plexus Blockade
Status: COMPLETED
Conditions: Underdosing of Local Anesthetics|Anesthetics, Local|Peripheral Nervous System Agents|Physiological Effects of Drugs
Interventions: OTHER: Procedure/Surgery: bupivakain % 0,5
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Closed-loop Control of Overnight Glucose Levels in Adults and Adolescents With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: OTHER: Carbohydrate-rich meal|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arrhythmia Detection In Obstructive Sleep Apnea (ADIOS)
Status: COMPLETED
Conditions: Atrial Fibrillation|Arrhythmia|Stroke, Cardiovascular
Interventions: DEVICE: The Lifestar Act III
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Comparative, Crossover, Pharmacokinetic, Pharmacodynamic and Safety Study of Three Forms of PEG-G-CSF in Normal Healthy Volunteers
Status: UNKNOWN
Conditions: Pharmacokinetics
Interventions: BIOLOGICAL: DRL_PG|BIOLOGICAL: Pegfilgrastim Form A|BIOLOGICAL: Pegfilgrastim Form B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Use of Viltolarsen in Boys With Duchenne Muscular Dystrophy in Clinical Practice (VILT-502)
Status: ACTIVE_NOT_RECRUITING
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: Viltolarsen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Conservative Treatment in Patients With Thoracic and Lumbar Fractures Without Neurological Deficit
Status: RECRUITING
Conditions: Thoracic Spine Fracture|Lumbar; Spine, Fracture|Thoracolumbar Burst Fracture|Fracture of Spine, Level Unspecified|Spine Fusion|Spine Fracture
Interventions: OTHER: rehabilitation treatment|PROCEDURE: Spine fusion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Painful Lumbar Radiculopathy
Status: COMPLETED
Conditions: Radiculopathy
Interventions: DRUG: Lenalidomide (CC-5013)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Functional Magnetic Resonance Imaging (fMRI) Investigation of Nicotine Withdrawal Symptoms
Status: COMPLETED
Conditions: Smoking
Interventions: DRUG: Nicotine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pilot Study of the Effect of Weight Loss on Breast Tissue and Blood Biomarkers in Women at Increased Risk for Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms|Obesity
Interventions: PROCEDURE: Biopsy|PROCEDURE: Blood draw|PROCEDURE: Mammogram|PROCEDURE: MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Triple Vulnerability? Circadian Tendency, Sleep Deprivation and Adolescence
Status: COMPLETED
Conditions: Eveningness/Sleep
Interventions: BEHAVIORAL: Cognitive Behavior Therapy for Insomnia, Interpersonal and Social Rhythms Therapy, Chronotherapy|BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SES Children (SES Mini/SES Nxt) - A Digital Intervention for Children of Divorce
Status: RECRUITING
Conditions: Parental Divorce|Parental Relationship Dissolution|Mental Health and Well-being
Interventions: BEHAVIORAL: SES Children (SES Mini & SES Nxt)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two-Part Dose-Confirming Study of Pulsed Inhaled Nitric Oxide in Subjects With WHO Group 3 Pulmonary Hypertension Associated With COPD
Status: COMPLETED
Conditions: Pulmonary Hypertension|Chronic Obstructive Pulmonary Disease
Interventions: COMBINATION_PRODUCT: Inhaled NO delivered via INOpulse DS-C Device|COMBINATION_PRODUCT: Placebo delivered via INOpulse DS-C Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Gender Specificity of the Effects of Furosemide in Healthy Female and Male Volunteers
Status: WITHDRAWN
Conditions: Healthy Male and Female Volunteers
Interventions: DRUG: Furosemide|DRUG: aminohippurate sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of a Leave-in Spray in Subjects With Head Lice Infestation
Status: RECRUITING
Conditions: Pediculosis Capitis|Lice Infestations|Head Lice
Interventions: OTHER: Vamousse Spray 'n' Go|DRUG: Nix Creme Rinse Lice Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Memory Retrieval Improvement in Healthy Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Adults
Interventions: DEVICE: active anodal tDCS|DEVICE: sham tDCS|DEVICE: active cathodal tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Mechanistic Evaluation of the Nociceptive Desensitizing Properties of Topical Capsaicin
Status: COMPLETED
Conditions: Capsaicin|Ultaviolet B Light Burn|Neuropathic Pain|Lidocaine
Interventions: DRUG: Capsaicin Topical|RADIATION: Ultraviolet-B (UVB) irradiation|OTHER: Histamine 1%|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Vitamin D on Drug Resistant Helicobacter Pylori (HP) Eradication Study
Status: UNKNOWN
Conditions: H. Pylori Infection
Interventions: DRUG: Esomeprazole|DRUG: Amoxicillin-Potassium Clavulanate Combination|DRUG: Clarithromycin|DRUG: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted Retreatment of COPD Exacerbations
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Ciprofloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of H1N1 Vaccines in Children Aged 6 Months to Less Than 9 Years of Age
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: GSK2340274A|BIOLOGICAL: GSK2340273A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Benefit of Dual-chamber Pacing With Closed Loop Stimulation (CLS) in Tilt-induced Cardioinhibitory Reflex Syncope
Status: COMPLETED
Conditions: Syncope
Interventions: DEVICE: DDD-CLS|DEVICE: ODO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cycled Testosterone Administration During Pulmonary Rehabilitation in Early Stage COPD
Status: WITHDRAWN
Conditions: COPD
Interventions: DRUG: Testosterone Enanthate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With Alpha-1 Antitrypsin Deficiency
Status: COMPLETED
Conditions: Emphysema|Alpha 1-Antitrypsin Deficiency
Interventions: DRUG: Hyaluronic Acid Inhalation Solution|DRUG: Placebo Inhalation Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assess Itch Behavior in Nickel Sulphate Sensitized Volunteers
Status: COMPLETED
Conditions: Allergic Contact Eczema
Interventions: DRUG: Adventan® (methylprednisolone aceponate 0,1%)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment of the Diagnostic Capacity of the Mini-broncho Alveolar Lavage Performed Through a Suction Catheter
Status: COMPLETED
Conditions: Bacterial Pneumonia
Interventions: DEVICE: catheter for mini bronchoalveolar lavage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Platelet-rich Factor on Implant Stability and Bone Resorption in the Lower Posterior Mandible
Status: UNKNOWN
Conditions: Osseointegrated Dental Implantation
Interventions: BIOLOGICAL: PRF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Gemfibrozil on the Safety and Pharmacokinetics of Red Yeast Rice in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Gemfibrozil & red yeast rice (LipoCol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Doxorubicin and Genexol-PM in Patients With Advanced Breast Cancer
Status: UNKNOWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Doxorubicin/Genexol-PM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualized Carbon-Ion Radiotherapy for Patients With Locally Recurrent Nasopharyngeal Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Locally Recurrent Nasopharyngeal Carcinoma
Interventions: RADIATION: Standardized CIRT|RADIATION: Individualized CIRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Extremely Early Antiretroviral Therapy to Reduce VIral REservoir and Induce Functional CURE of HIV-1 Infection
Status: UNKNOWN
Conditions: HIV Infections
Interventions: DRUG: Antiretroviral Therapy (Experimental)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Purpose of This Research is to Investigate the Effects of Aerobic Exercise on Executive Function in Obese Children
Status: NOT_YET_RECRUITING
Conditions: Executive Function Disorder|Obesity, Childhood
Interventions: BEHAVIORAL: Aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Elderly Patients With Acute Myeloid Leukemia (AML), Maintenance Phase After Complete Remission (CR)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: azacitidine|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of a Glaucoma Drug Delivery System
Status: COMPLETED
Conditions: Glaucoma, Open-Angle|Ocular Hypertension
Interventions: DRUG: High Dose Device|DRUG: Low Dose Device|DEVICE: Placebo Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Comparison of Vaginal Self Sampling for Human Papillomavirus (HPV) Testing by Standard Versus Dry Vaginal Swabs
Status: UNKNOWN
Conditions: Human Papillomavirus Infection
Interventions: OTHER: Compare different self-obtained specimen for HPV identification|OTHER: Compare different self-obtained specimen for HPV identification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Introduction of Preconception Care Through Public Health System for Improving MNCH&FP
Status: ACTIVE_NOT_RECRUITING
Conditions: Feasibility|Acceptability of Health Care
Interventions: BEHAVIORAL: Preconception care (PCC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Results of Endoscopic Gastroplasty Using Overstitch in Patients With Class I and II Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: PROCEDURE: Device arm|PROCEDURE: Sham arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Different Fissure Sealant Materials in the Newly Erupted Non-Carious First Permanent Molars
Status: COMPLETED
Conditions: Fissure Sealant
Interventions: DEVICE: Fuji® II LC CAPSULE|DEVICE: Clinpro™ XT Varnish|DEVICE: Beautifil Flow|DEVICE: Fuji Triage® CAPSULE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I, First-in-man Study of OTX008 Given Subcutaneously as a Single Agent to Patients With Advanced Solid Tumors
Status: UNKNOWN
Conditions: Solid Tumors
Interventions: DRUG: OTX008
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reliability of a New Pulse Contour Technique for Diagnosing an Increase in Stroke Volume During a Fluid Challenge for Hemodynamic Optimization in Patients Scheduled for High-risk Abdominal Surgery: Comparison With Transthoracic Echocardiography: COMPARE Study
Status: UNKNOWN
Conditions: Surgery|Cardiac Output, Low
Interventions: DIAGNOSTIC_TEST: >15% SV increase during fluid challenge
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Impact of Arnica Montana Following the Surgical Extraction of Impacted Third Molars
Status: COMPLETED
Conditions: Edema|Pain|Trismus
Interventions: DRUG: Arnica montana|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Blood Pressure Control in End-Stage Renal Disease Through a Supportive-Educative Nursing Intervention
Status: COMPLETED
Conditions: Hypertension|Hemodialysis
Interventions: BEHAVIORAL: BP education and BP self-regulation|BEHAVIORAL: Supportive Educative Nursing Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Neuromuscular Stimulation on Post-Transplant Leg Edema
Status: COMPLETED
Conditions: Kidney Transplant|Kidney Pancreas Transplant|Edema
Interventions: DEVICE: Geko device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ramelteon in the Treatment of Sleep and Mood in Patients With Seasonal Affective Disorder
Status: COMPLETED
Conditions: Seasonal Affective Disorder
Interventions: DRUG: Ramelteon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Rosuvastatin With Atorvastatin in Chronic Periodontitis
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: DRUG: SRP with RSV gel LDD|DRUG: SRP with ATV gel LDD|DRUG: SRP with placebo gel LDD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cell Transplantation in the Treatment of Chronic Allograft Nephropathy
Status: UNKNOWN
Conditions: Kidney Transplant|Chronic Allograft Nephropathy
Interventions: BIOLOGICAL: mesenchymal stem cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Research Medicine CIN-103 in Adults With Irritable Bowel Syndrome With Predominant Diarrhea (IBS-D).
Status: RECRUITING
Conditions: Irritable Bowel Syndrome With Diarrhea
Interventions: DRUG: CIN-103|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Istradefylline (KW-6002) in Treating Patients With Parkinson's Disease on Levodopa
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Istradefylline (KW-6002)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Adult Solid Neoplasm
Interventions: DRUG: Gamma-Secretase Inhibitor RO4929097|DRUG: Ketoconazole|DRUG: Rifampin|DRUG: Midazolam Hydrochloride|DRUG: Omeprazole|DRUG: Tolbutamide|DRUG: Dextromethorphan Hydrobromide|OTHER: Pharmacological Study|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Lenalidomide and Eltrombopag in Patients With Symptomatic Anemia
Status: COMPLETED
Conditions: Adult Myelodysplastic Syndrome|Anemia|Chronic Myelomonocytic Leukemia
Interventions: DRUG: Eltrombopag Olamine|OTHER: Laboratory Biomarker Analysis|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Adjunctive Systemic Vitamin E on Clinical Parameters and Salivary Total Antioxidant Capacity in Symptomatic Oral Lichen Planus Patients: Randomized-controlled Clinical Trial
Status: COMPLETED
Conditions: Oral Lichen Planus
Interventions: DIETARY_SUPPLEMENT: topical corticosteroids and vitamin E suplements|DRUG: Topical corticosteroid and placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risk-Adapted Therapy of Acute Myeloid Leukemia of Adults (18-60 Years) According to the Cytogenetic Result
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Idarubicin|DRUG: Cytosin-Arabinosid|DRUG: Etoposide|DRUG: All-trans Retinoid acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Research Studying a Method of Intervention for Children Diagnosed With Anxiety Disorder: Attentional Bias Intervention
Status: COMPLETED
Conditions: Anxiety
Interventions: BEHAVIORAL: attention-bias training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial
Status: RECRUITING
Conditions: Metastatic Malignant Neoplasm in the Brain|Metastatic Malignant Solid Neoplasm
Interventions: OTHER: Questionnaire Administration|RADIATION: Stereotactic Radiosurgery|RADIATION: Stereotactic Radiosurgery|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Most Closely Human Leukocyte Antigen (HLA)-Matched Adenovirus-specific T Lymphocytes (Viralym-A)
Status: WITHDRAWN
Conditions: Adenovirus Infection
Interventions: BIOLOGICAL: Viralym-A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Enteric-coated Mycophenolate Sodium and Cyclosporine in Combination With and Without Steroids, in Adult Renal Transplant Recipients
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: Enteric-coated mycophenolate sodium (EC-MPS)|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study of YM178 in Normal Subjects and Those With Mild, Moderate, and Severe Renal Impairment
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: YM178
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: A Study Of The Effects Of PF-04958242 In Subjects With Age-Related Hearing Loss
Status: COMPLETED
Conditions: Hearing Loss, Sensorineural
Interventions: DRUG: PF-04958242|DRUG: PF-04958242|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Training Curriculum and Service of Improving Access to Community Therapies
Status: RECRUITING
Conditions: Depression|Anxiety|Mental Health Issue|Stress|Distress, Emotional
Interventions: BEHAVIORAL: Improving Access to Community Therapies (iACT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irinotecan Discontinuation and Reintroduction for Advanced Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Neoplasms|Metastases
Interventions: DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tailored Smoking Cessation Intervention in Promoting Sexual and Gender Minority Smokers to Quit Smoking
Status: COMPLETED
Conditions: Cigarette Smoker|Current Every Day Smoker
Interventions: OTHER: Informational Intervention|BEHAVIORAL: Telephone-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety Study of Neuramis in Correction of Nasolabial Fold
Status: COMPLETED
Conditions: Nasolabial Fold
Interventions: DEVICE: HA filler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of STX209 (Arbaclofen) for the Treatment of Social Withdrawal in Children With Fragile X Syndrome
Status: COMPLETED
Conditions: Fragile X Syndrome
Interventions: DRUG: arbaclofen|DRUG: arbaclofen|DRUG: arbaclofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SCG142 TCR-T Cells for Human Papillomavirus-Associated Carcinomas
Status: RECRUITING
Conditions: Human Papillomavirus Associated Carcinomas|Cervical Cancer|Head and Neck Cancers|Anal Cancer|Vulva Cancer|Vaginal Cancer|Penile Cancer|HPV-Related Malignancy
Interventions: BIOLOGICAL: SCG142 TCR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lower-Limb Adventitial Infusion of DexaMethasone Via Bullfrog to Reduce Occurrence of Restenosis After Atherectomy (ATX)-Based Revascularization
Status: UNKNOWN
Conditions: Chronic Limb Ischemia
Interventions: DRUG: Dexamethasone Sodium Phosphate Injection, USP, 4 mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PericOronary INflammaTion in Non-Obstructive Coronary Artery Disease
Status: RECRUITING
Conditions: Non-Obstructive Coronary Atherosclerosis
Interventions: PROCEDURE: Coronary computed tomography angiography (CCTA)|DRUG: Isovue|DRUG: Nitroglycerin|DRUG: Metoprolol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Subcutaneous Daratumumab Versus Active Monitoring in Participants With High-Risk Smoldering Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Smoldering Multiple Myeloma
Interventions: DRUG: Daratumumab SC: daratumumab + rHuPH20
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Abemaciclib (LY2835219) in Participants With Breast Cancer, Non-small Cell Lung Cancer, or Melanoma That Has Spread to the Brain
Status: COMPLETED
Conditions: Breast Cancer|Non-small Cell Lung Cancer|Melanoma|Brain Metastases
Interventions: DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Immunogenicity and Safety of HPV Vaccine in Healthy Female Participants Aged 9-26 Years in China
Status: ACTIVE_NOT_RECRUITING
Conditions: Human Papillomavirus Infection
Interventions: BIOLOGICAL: Recombinant Nonavalent (types 6/11/16/18/31/33/45/52/58) Human Papillomavirus (HPV) Vaccine (Escherichia coli)|BIOLOGICAL: GARDASIL® 9
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy, Safety and Pharmacokinetics/Pharmacodynamics (PK/PD) of Ocrelizumab in Patients With Rheumatoid Arthritis
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: placebo|DRUG: methotrexate|DRUG: ocrelizumabu 50mg|DRUG: ocrelizumabu 200mg|DRUG: ocrelizumab 500mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sex Differences in Progesterone Effects on Responses to Stress and Drug Cues
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: Progesterone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Trial of Rad-223 Activity in Asymptomatic Patients With mCRPC While on Abiraterone or Enzalutamide Besides AR-V7 Status
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: radium-223
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of the 3/7 vs 3X9 Method in Resistance Training on Metabolic Stress in Cardiac Rehabilitation
Status: COMPLETED
Conditions: Heart Failure|Resistance Training|Coronary Artery Disease
Interventions: OTHER: Cardiac rehabilitation with 3/7 method|OTHER: Cardiac rehabilitation with 3X9 method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Virologic Effect of a Human Monoclonal Antibody (VRC01) Administered Intravenously to Adults During Early Acute HIV Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: VRC01|BIOLOGICAL: Placebo for VRC01|DRUG: Antiretroviral therapy (ART) (regimen will vary within countries and by patient)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Single Dose of 5 mg Zoledronic Acid in Chinese Patients With Paget's Disease of Bone (PDB)
Status: COMPLETED
Conditions: Paget's Disease of Bone
Interventions: DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accelerated Neuromodulation to Alleviate Cognitive Deficits Due to Cancer Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer
Interventions: OTHER: Accelerated repetitive intermittent theta-burst transcranial stimulation (iTBS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)
Status: RECRUITING
Conditions: Severe Aplastic Anemia
Interventions: DRUG: Eltrombopag|DRUG: Cyclosporine|DRUG: Horse-Anti-thymocyte-Globulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Immunogenicity Study of Different Vaccine Schedules With Ad26.Mos.HIV and Clade C Glycoprotein (gp)140 in Healthy Human Immunodeficiency Virus (HIV)-Uninfected Adults
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Ad26.Mos.HIV|BIOLOGICAL: Clade C gp140|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Optic Nerve Sheath Measurement and Angiogenic Factors in Patients With Pre-eclampsia.
Status: NOT_YET_RECRUITING
Conditions: Pre-Eclampsia
Interventions: PROCEDURE: ONSD+AF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Debridement, Antibiotics and Implant Retention in Early Periprosthetic Joint Infection: A Retrospective Cohort Study
Status: COMPLETED
Conditions: Direct Infection of Hip- and Knee Arthroplasty
Interventions: PROCEDURE: Debridement, antibiotics and implant retention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Using a Dragon Design Nebulizer Mask on Treatment Duration, Compliance and Fear in Children
Status: NOT_YET_RECRUITING
Conditions: Fear
Interventions: DEVICE: dragon themed nebulizer masks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Envafolimab Combined With Endostar and Chemotherapy for First-line Treatment of Advanced Pancreatic Cancer
Status: UNKNOWN
Conditions: Advanced Pancreatic Cancer
Interventions: DRUG: Envafolimab|DRUG: Endostar|DRUG: Nab paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Intravenous Zanamivir Versus Oral Oseltamivir in Adults and Adolescents Hospitalized With Influenza
Status: COMPLETED
Conditions: Influenza, Human
Interventions: DRUG: Zanamivir|DRUG: Placebo to match zanamivir|DRUG: Oseltamivir|DRUG: Placebo to match oseltamivir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment Of Right Ventricular Function In Patients Undergoing Coronary Artery Bypass Graft In Assiut University
Status: UNKNOWN
Conditions: CORONARY ARTERY BYPASS
Interventions: DIAGNOSTIC_TEST: 2D Echocardiography and 3D Echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Evaluating Safety and Efficacy of BIOD-123 Compared to Insulin Lispro (Humalog®)
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: BIOD-123|DRUG: Lispro (Humalog)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Augmentation of Neuronal Network Plasticity in Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia|Healthy
Interventions: BEHAVIORAL: 3D navigation video game intervention|BEHAVIORAL: video game intervention without 3D navigation|BEHAVIORAL: No 3D navigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase I/II Trial of VELCADE + CHOP-Rituximab in Untreated DLCBL or Mantle Cell NHL
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Bortezomib, CHOP, Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Heparin Bonded Vascular Graft Versus Standard Graft in Prosthetic Arteriovenous Access for Hemodialysis
Status: COMPLETED
Conditions: Hemodialysis Fistula Thrombosis
Interventions: PROCEDURE: Prosthetic AV graft implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-line Antimetabolites as Steroid-sparing Treatment Uveitis Pilot Trial
Status: COMPLETED
Conditions: Uveitis
Interventions: DRUG: Methotrexate|DRUG: Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of b-2Cool on Adults With Joint Discomfort
Status: WITHDRAWN
Conditions: Joint Discomfort
Interventions: DIETARY_SUPPLEMENT: b-2Cool|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Pilocarpine Ophthalmic Topical Cream for the Treatment of Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Disease|Kerato Conjunctivitis Sicca
Interventions: DRUG: Pilocarpine Ophthalmic Topical Cream, Dose 1|DRUG: Pilocarpine Ophthalmic Topical Cream, Dose 2|DRUG: Pilocarpine Ophthalmic Topical Cream, Dose 3|DRUG: Placebo Ophthalmic Topical Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeting the Gut Microbiome to Investigate the Pathways of Progression From Obesity to Metabolic Diseases in an At-risk Population.
Status: COMPLETED
Conditions: Obesity|Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: Lactobacillus paracasei ssp paracasei F19|DIETARY_SUPPLEMENT: Flax seed fibres|DIETARY_SUPPLEMENT: Maltodextrin (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Analgesia-Nociception Index Guided Intraoperative Remifentanil Administration Versus Standard Practice:Evaluation of Perioperative Opioid Use
Status: COMPLETED
Conditions: Pain|Anesthesia
Interventions: DEVICE: Analgesia Nociception Index|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE