pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)
Status: RECRUITING
Conditions: Prostate Cancer Metastatic
Interventions: DRUG: Opevesostat|DRUG: Abiraterone acetate|DRUG: Enzalutamide|DRUG: Hydrocortisone|DRUG: Fludrocortisone acetate|DRUG: Prednisone|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EPA Supplementation in Cancer Patients Receiving Abdominal Radiotherapy -
Status: UNKNOWN
Conditions: Abdominal Cancer|Radiotherapy; Complications|Weight Loss|Energy Supply|Protein Deficiency
Interventions: DIETARY_SUPPLEMENT: Fish oil|OTHER: standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fludarabine, Cyclophosphamide, Doxorubicin and Rituximab for the Treatment of Post-transplant Lymphoproliferative Disease (PTLD)
Status: COMPLETED
Conditions: Post-transplant Lymphoproliferative Disease (PTLD)|Non Burkitt
Interventions: DRUG: fludarabine, cyclophosphamide, doxorubicin, rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation of Oral Simethicone With Low Volume Polyethylene Glycol Bowel Preparation During Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: Simethicone Solution|DRUG: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Early Postoperative Extracorporal Liver Support Therapy (ELS) as a Tool to Manage Post Hepatectomy Liver Failure (PLF)
Status: COMPLETED
Conditions: Post Hepatectomy Liver Failure
Interventions: DEVICE: Extracorporeal liver support therapy (ELS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Curarization During Anesthesia for Gynecologic Surgical Laparotomy Procedures
Status: UNKNOWN
Conditions: Curarization, Postoperative Residual
Interventions: DRUG: Sugammadex|DRUG: Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Dapagliflozin on Volume Vascular Outcomes.
Status: RECRUITING
Conditions: Heart Failure，Congestive
Interventions: DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Topical Mitomycin C as Adjuvant Drug to Esophageal Dilation in Children
Status: UNKNOWN
Conditions: Esophageal Stricture|Caustic Esophageal Stricture|Peptic Esophageal Stricture|Post-Surgical Esophageal Stricture
Interventions: DRUG: Mitomycin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Metabolic, Transcriptomic and Proteomic Characteristics in Relapsed Glioblastoma
Status: NOT_YET_RECRUITING
Conditions: Relapsed Cancer|Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype
Interventions: BIOLOGICAL: Relapsed glioblastoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PillSense System for Detecting UGI Bleed
Status: COMPLETED
Conditions: UGI Bleed|Upper Gastrointestinal Bleeding|Upper Gastrointestinal Bleed
Interventions: DIAGNOSTIC_TEST: PillSense
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clazakizumab vs. Placebo - COVID-19 Infection
Status: UNKNOWN
Conditions: COVID-19 Infection
Interventions: DRUG: Clazakizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Performance Study of the Harpoon Mitral Valve Repair System
Status: TERMINATED
Conditions: Mitral Valve Regurgitation|Mitral Valve Prolapse|Mitral Valve Insufficiency
Interventions: DEVICE: Harpoon Artificial ePTFE Chords
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simulation-Based Caregiving Skills Training for Family Members of High Grade Glioma Patients
Status: RECRUITING
Conditions: Glioma
Interventions: BEHAVIORAL: Questionnaires|BEHAVIORAL: Caregiver Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomised Clinical Trial for New Treatment Modalities for Cutaneous Leishmaniasis Caused by Leishmania Tropica, in Pakistan
Status: UNKNOWN
Conditions: Old World Cutaneous Leishmaniasis
Interventions: COMBINATION_PRODUCT: drug: miltefosine with thermotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Cost-Effectiveness of Robot Therapy With the Paro Robot in People Living With Dementia
Status: COMPLETED
Conditions: Dementia|Neurocognitive Disorders|Mild Cognitive Impairment
Interventions: BEHAVIORAL: PARO Therapy Robot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Breakfast Consumption in Preschoolers: Satiety, Diet Quality and Memory
Status: COMPLETED
Conditions: Lack of Satiety|Dietary Modification|Memory Deficits|Obesity
Interventions: OTHER: High fiber breakfast|OTHER: High Protein Breakfast|OTHER: High Protein/High Fiber Breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Serial Infusions of Allogeneic Mesenchymal Stem Cells in Cardiomyopathy Patients With Left Ventricular Assist Device
Status: TERMINATED
Conditions: Ischemic Heart Disease|Non-ischemic Cardiomyopathy
Interventions: BIOLOGICAL: Human Allogeneic Mesenchymal Bone Marrow Cells (aMBMC)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Desensitizing Agents on Post-bleaching Hypersensitivity and Shade Stability
Status: COMPLETED
Conditions: Tooth Hypersensitivity
Interventions: OTHER: Potassium nitrate with fluoride|OTHER: Casein phosphopeptide-amorphous calcium phosphate with fluoride|OTHER: Hydroxyapatite with fluoride|OTHER: PAMAM-carboxylic acid dendrimer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Naltrexone in Women's Smoking Cessation
Status: COMPLETED
Conditions: Smoking|Smoking Cessation
Interventions: DRUG: Naltrexone (drug)|DRUG: Placebo (for Naltrexone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Injection Laryngoplasty Using Autologous Fat Enriched With Adipose Derived Regenerative Stem Cells (ADRC)
Status: COMPLETED
Conditions: Vocal Cord Paralysis, Unilateral
Interventions: BIOLOGICAL: adipose derived regenerative cells|BIOLOGICAL: centrifuged autologous fat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atezolizumab in Patients With MSI-h/MMR-D Stage III Colorectal Cancer Ineligible for Oxaliplatin
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CKD-828 (80/5mg) Pharmacokinetic Study
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: CKD-828|DRUG: Telmisartan|DRUG: S-amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prasugrel/Clopidogrel Maintenance Dose Washout Study
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Prasugrel|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between the Effect of Using Conventional and Digital Oral Positional Radiation Stent
Status: COMPLETED
Conditions: Radiotherapy Side Effect
Interventions: DEVICE: conventional oral positioning stent were used during radiation planning and the PTV will be defined and contoured in computed tomography pre irradiation planning|DEVICE: Digital positioning stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fixed Low-dose Simethicone Combined With Macrogol 4000 (PEG) Reduces Colon Bubble Formation in Colonoscopy
Status: COMPLETED
Conditions: Colorectal Cancer|Colonoscopy|Bowel Preparation Solution
Interventions: DRUG: Simethicone combined with Macrogol 4000 (PEG)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome
Status: RECRUITING
Conditions: Familial Cancer|BRCA1-Associated Protein-1 (BAP1) Mutations|Tumor Predisposition Syndrome (TPDS)|Mesothelioma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MK0524B Bioequivalence Study (0524B-070)
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: MK0524B (ER niacin (+) laropiprant (+) simvastatin)|DRUG: MK0524A (ER niacin + laropiprant)|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Protocol for Peri-Implantitis Treatment-3
Status: UNKNOWN
Conditions: Peri-Implantitis
Interventions: PROCEDURE: Chlorhexidine|PROCEDURE: Connective Tissue Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel, Androgen Deprivation and Proton Therapy for High Risk Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: RADIATION: < 15% risk of + LN|RADIATION: > 15% risk of + LN
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibuprofen 4% (w/v) Pivotal Bioequivalence Study
Status: COMPLETED
Conditions: Bioequivalence of the Test Formulation
Interventions: DRUG: Nurofen for Children®|DRUG: Algifor® Junior
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A pragmatiC sTrategy to Promote actIVity and Enhance Quality of Life AFTER Transcatheter Aortic Valve Replacement
Status: COMPLETED
Conditions: Aortic Valve Stenosis
Interventions: BEHAVIORAL: Daily Activity Goal|BEHAVIORAL: Resistance Exercises|BEHAVIORAL: Daily Activity Recording
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of NP-120 (Ifenprodil) for the Treatment of Hospitalized Patient With Confirmed COVID-19 Disease
Status: COMPLETED
Conditions: COVID
Interventions: DRUG: NP-120 (Ifenprodil)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "MyPlan" - Individualized Planned Eating Patterns for Adolescents With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: BEHAVIORAL: "MyPlan" - Individualized Planned Eating Pattern
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycemic Effect of Colesevelam HCl (Welchol) in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: colesevelam HCl|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing Relapse Following Involuntary Smoking Abstinence
Status: UNKNOWN
Conditions: Smoking|Smoking Cessation
Interventions: BEHAVIORAL: Tobacco Use Ban|BEHAVIORAL: Tailored Pamphlet|BEHAVIORAL: Informational Pamphlet|BEHAVIORAL: Relapse Prevention Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Learn About a Type of Pneumococcal Vaccine With a New Ingredient (PF-07872411) Intended to Enhance the Effects of the Vaccine Which is Given to Adults
Status: COMPLETED
Conditions: Pneumococcal Disease
Interventions: OTHER: Low dose multivalent pneumococcal conjugate vaccine formulation A|OTHER: Low dose multivalent pneumococcal conjugate vaccine formulation B|BIOLOGICAL: Low dose of multivalent pneumococcal conjugate vaccine control|BIOLOGICAL: Standard dose multivalent pneumococcal conjugate vaccine control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Anti-Vascular Endothelial Growth Factor (Anti-VEGF) Alone Versus Ozurdex Given Every 3 Months for Treatment of Persistent Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Ozurdex|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Use of Acellular Dermal Matrix for Breast Reconstruction
Status: RECRUITING
Conditions: Breast Cancer
Interventions: PROCEDURE: Prepectoral Breast Reconstruction with Acellular Dermal Matrix (ADM)|PROCEDURE: Prepectoral Breast Reconstruction without Acellular Dermal Matrix (ADM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Global Research Initiative for Patients Screening on MASH
Status: RECRUITING
Conditions: MASH|MASLD|MASH With Fibrosis|Fibrosis, Liver|Steatosis of Liver|Type 2 Diabetes|Obesity|Metabolic Syndrome|Arterial Hypertension
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of a Reduced-toxicity "Submyeloablative" Conditioning Regimen Prior to Allogeneic Stem Cell Transplantation in Patients With Hematological Malignancies
Status: COMPLETED
Conditions: Hematological Malignancies
Interventions: DRUG: Fludarabine, Busulfan, Thymoglobuline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet-Delivered Pain Self-Management for Persons With Acute Recurrent and Chronic Pancreatitis Pain
Status: RECRUITING
Conditions: Pancreatitis|Chronic Pancreatitis|Acute Recurrent Pancreatitis
Interventions: BEHAVIORAL: Internet-delivered pain self-management (CBT Condition)|BEHAVIORAL: Education Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Anaplastic Medulloblastoma|Medulloblastoma|Supratentorial Embryonal Tumor, Not Otherwise Specified|Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor
Interventions: PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Cyclophosphamide|DRUG: Etoposide|BIOLOGICAL: Filgrastim|OTHER: Laboratory Biomarker Analysis|DRUG: Leucovorin Calcium|DRUG: Methotrexate|OTHER: Quality-of-Life Assessment|DRUG: Thiotepa|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myelofibrosis Treated With Pacritinib Before aSCT. (HOVON134MF)
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelofibrosis
Interventions: DRUG: Pacritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Renal Colic in the Emergency Departement (ED).
Status: COMPLETED
Conditions: Renal Colic
Interventions: DRUG: Diclofenac|DRUG: Magnesium Sulfate|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of Reduced-antigen-content Acellular Pertussis Vaccine and Diphtheria-Tetanus-Acellular Pertussis Vaccine
Status: COMPLETED
Conditions: Diphteria, Tetanus and Pertussis
Interventions: BIOLOGICAL: GSK Biologicals' reduced-antigen-content diphtheria-tetanus-acellular pertussis vaccine|BIOLOGICAL: GSK Biologicals' reduced-antigen-content acellular pertussis vaccine|BIOLOGICAL: Tedivax-Adult™/ Td-Rix™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study Assessing the Effects on Endometrium and Breast of Isoflavone in Post Menopausal Women
Status: UNKNOWN
Conditions: Postmenopause
Interventions: DRUG: soy isoflavone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Safety and Efficacy of Cannabis in Participants With Chronic Posttraumatic Stress Disorder
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: High THC/Low CBD Cannabis|DRUG: High THC/High CBD Cannabis|DRUG: Low THC/Low CBD Cannabis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HEARD (Long Term) Study - Histology of the Esophagus in Acid-Related Disease
Status: COMPLETED
Conditions: Gastroesophageal Reflux|Heartburn|Dyspepsia
Interventions: DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ADCT-301 in Patients With R/R AML, MDS, or MDS/MPN
Status: TERMINATED
Conditions: Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome (MDS)|Myeloproliferative Neoplasm (MDS/MPN)
Interventions: DRUG: ADCT-301
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Avelumab as Neoadjuvant Therapy in Subjects With Urothelial Muscle Invasive Bladder Cancers (AURA Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-metastatic Muscle Invasive Bladder Cancer
Interventions: DRUG: Avelumab|PROCEDURE: cystectomy|COMBINATION_PRODUCT: CG|COMBINATION_PRODUCT: DD-MVAC|COMBINATION_PRODUCT: PG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Study the Hemodynamic Response of Early Addition of Carvedilol to Terlipressin in Acute Variceal Bleed in Child's B and C Cirrhosis
Status: RECRUITING
Conditions: Liver Cirrhosis
Interventions: DRUG: Carvedilol Day2|OTHER: Standard Medical Treatment|DRUG: Carvedilol Day6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study of Once Daily Efavirenz 400 mg Versus 600 mg in Thai HIV-1 Infected Subjects
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allergic Rhinitis Combination Pharmacotherapy Efficacy Study
Status: WITHDRAWN
Conditions: Allergic Rhinitis
Interventions: DRUG: Fluticasone Propionate|DRUG: Azelastine hydrochloride and fluticasone propionate|DRUG: Rupatadine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Retrospective Study in Patients With Metastatic Renal Cancer Treated With TKI Sequence (Tyrosine Kinase Inhibitors of VEGFR) - mTOR- Axitinib Inhibitors or Anti-VEGF Antibody -Inhibiteurs mTOR - Axitinib
Status: UNKNOWN
Conditions: Kidney Neoplasms
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open and Endoscopic Technique in Female Inguinal Hernia Repair. FemaleHernia
Status: NOT_YET_RECRUITING
Conditions: Post Operative Pain
Interventions: PROCEDURE: Open hernioplasty|PROCEDURE: TEP hernioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Aezea® (Cenersen) in Transfusion Dependent Anemia Associated With Myelodysplastic Syndrome (MDS)
Status: TERMINATED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: cenersen|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Doxorubicin in Treating Patients With Advanced Solid Tumors Affecting the Lungs
Status: COMPLETED
Conditions: Lung Cancer|Malignant Mesothelioma|Metastatic Cancer
Interventions: DRUG: doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Alemtuzumab to Treat Severe Aplastic Anemia
Status: COMPLETED
Conditions: Severe Aplastic Anemia, Refractory|Severe Aplastic Anemia, Relapse
Interventions: BIOLOGICAL: Alemtuzumab (Campath )|DRUG: Cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Colchicine for Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement
Status: ACTIVE_NOT_RECRUITING
Conditions: Transcatheter Aortic Valve Replacement|Atrial Fibrillation New Onset|Pacemaker|Colchicine
Interventions: DRUG: Colchicine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Blood Propofol Concentrations in Children During Spinal Surgery
Status: COMPLETED
Conditions: Spine Deformities|Idiopathic Scoliosis|Neuromuscular Dystrophy
Interventions: DEVICE: Pelorus 1500|DRUG: Propofol 2% (Diprivan 2%, Astra Zeneca UK)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose:
Clinical trial: A Study of Rizatriptan Co-Administered With Acetaminophen for the Treatment of Acute Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Rizatriptan co-administered with Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Efficacy of the Erector Spinae Plane Block Using Bupivacaine Versus Bupivacaine/Magnesium Sulphate in Patients Undergoing Lumbar Spine Surgery
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: OTHER: Group (B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Efficacy and Safety of LCI699 in Participants With Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: LCI699|DRUG: Eplerenone|DRUG: LCI699-matching Placebo|DRUG: Eplerenone-matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SBRT With Focal Dose Escalation on DIL in Localized Prostate Cancer
Status: RECRUITING
Conditions: Prostate Adenocarcinoma
Interventions: RADIATION: Prostate SBRT (stereotactic body radiation therapy) with focal boost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Epinephrine and Intravenous (I.V.) Needle on Cardiopulmonary Resuscitation (CPR) Outcome
Status: COMPLETED
Conditions: Cardiac Arrest
Interventions: DRUG: Epinephrine|DEVICE: Intravenous needle|DRUG: Atropine|DRUG: Amiodarone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy Volunteers
Status: RECRUITING
Conditions: Amyotrophic Lateral Sclerosis (ALS)|Parkinson Disease (PD)|Alzheimer Disease (AD)|Multiple Sclerosis (MS)
Interventions: DRUG: 18F-OP-801
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: TR-987 vs. Placebo Following Fractionated CO2 Laser Resurfacing of the Chest
Status: COMPLETED
Conditions: Exposure Laser
Interventions: OTHER: TR987 Gel with Silon Bandage|OTHER: TR987 without Silon Bandage|OTHER: Placebo Gel with Silon Bandage|OTHER: Placebo Gel without Silon Bandage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolomic Analysis of the Impacts of Hydration Status on Exercise Performance
Status: TERMINATED
Conditions: Dehydration|Physical Exertion|Salivary Osmolar Concentration|Urinary Osmolar Concentration
Interventions: DIETARY_SUPPLEMENT: Kona Deep|DIETARY_SUPPLEMENT: Spring Water|DIETARY_SUPPLEMENT: Sports Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Educational CD-ROM Compared With Standard Informed Consent for Patients With Colorectal Cancer or a Family History of Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Hereditary Non-polyposis Colon Cancer
Interventions: OTHER: counseling intervention|OTHER: CD-ROM intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Effects of Eccentric Exercises on Gait Parameters in Patellofemoral Pain Syndrome: A Quasi-Experimental Study
Status: RECRUITING
Conditions: Patellofemoral Pain Syndrome
Interventions: PROCEDURE: McConnell Taping|PROCEDURE: ECCENTRIC EXERCISES:
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability of GEN6050X in Duchenne Muscular Dystrophy.
Status: RECRUITING
Conditions: Duchenne Muscular Dystrophy (DMD)
Interventions: GENETIC: GEN6050X intravenous injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nicotinamide Chemoprevention for Keratinocyte Carcinoma in Solid Organ Transplant Recipients - Pivotal Trial
Status: RECRUITING
Conditions: Non-melanoma Skin Cancer|Carcinoma, Squamous Cell|Carcinoma, Basal Cell|Keratinocyte Carcinoma
Interventions: DRUG: Nicotinamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Safety and PK of LODIENT Tablet 80/2.5mg in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Twynsta|DRUG: LodineT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gene Modified Immune Cells (IL13Ralpha2 CAR T Cells) After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Metastatic Malignant Solid Neoplasm|Metastatic Melanoma|Pathologic Stage IIIC Cutaneous Melanoma AJCC v8|Pathologic Stage IV Cutaneous Melanoma AJCC v8|Recurrent Malignant Solid Neoplasm|Refractory Malignant Solid Neoplasm|Uveal Melanoma|Acral Melanoma|Neuroendocrine Tumors|Paraganglioma|Pheochromocytoma|Adrenocortical Carcinoma|Pancreatic Neuroendocrine Tumor|Thyroid Cancer|Breast Cancer|Lung Adenocarcinoma|Head and Neck Squamous Cell Carcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Cyclophosphamide|DRUG: Fludarabine Phosphate|OTHER: Fludeoxyglucose F-18|BIOLOGICAL: IL13Ralpha2-specific Hinge-optimized 4-1BB-co-stimulatory CAR/Truncated CD19-expressing Autologous TN/MEM Cells|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Research of NK Cell Infusion Combined With Chemotherapy in the Treatment of Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: NK cells|DRUG: Taxol|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety/Immunogenicity of Immunizations of ALVAC-DC-SC vs ALVAC-SC
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: ALVAC(2)120(B,MN)GNP (vCP1452)|DRUG: Keyhole-Limpet Hemocyanin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Behavioral Treatment of Insomnia on Nighttime Urine Production
Status: COMPLETED
Conditions: Sleep Fragmentation|Poor Quality Sleep|Nocturia|Nocturnal Enuresis
Interventions: BEHAVIORAL: Brief behavioral treatment of insomnia (BBTI)|BEHAVIORAL: Information-only control (IC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Parecoxib vs. Dexketoprofen for the Management of Pain After Cesarean Section.
Status: COMPLETED
Conditions: Caesarean Section; Pain
Interventions: DRUG: Parecoxib|DRUG: Dexketoprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carnitine Supplementation in Pediatric Hemodialysis Patients
Status: RECRUITING
Conditions: Carnitine Deficiency Due to Hemodialysis
Interventions: DRUG: L-carnitine|OTHER: isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing Two Pertussis-containing Vaccines in Pregnancy and Vaccine Responses in UK Mothers and Their Infants
Status: COMPLETED
Conditions: Responses to Infant Immunisations
Interventions: DRUG: Repevax|DRUG: Boostrix-IPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Tial of Er:YAG Laser Snoring Treatment
Status: RECRUITING
Conditions: Snoring
Interventions: DEVICE: LP Er:YAG|DEVICE: SMOOTH mode Er:YAG|DEVICE: sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Oculopharyngeal Muscular Dystrophy With Trehalose
Status: WITHDRAWN
Conditions: Oculopharyngeal Muscular Dystrophy
Interventions: DRUG: Trehalose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The ID- RFA Trial: A Trial of Intraductal Radio-frequency Ablation (ID-RFA) Plus Biliary Stenting Versus Biliary Stenting Alone for the Treatment of Malignant Biliary Obstruction.
Status: UNKNOWN
Conditions: Malignant Biliary Obstruction
Interventions: PROCEDURE: Intraductal Radio-Frequency Ablation|DEVICE: Biliary Stent Placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: K01 Impacts of Lingual Endurance Exercise
Status: RECRUITING
Conditions: Dysphagia|Dysphagia, Oropharyngeal|Ischemic Stroke
Interventions: BEHAVIORAL: Isotonic Endurance Exercise|BEHAVIORAL: Sham Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carotid Artery Implant for Preventing Stroke in Atrial Fibrillation Patients Taking Oral Anticoagulants
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation|Stroke
Interventions: DEVICE: Vine™ Embolic Protection System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 5-Cog 2.0: A Pragmatic Clinical Trial
Status: RECRUITING
Conditions: Dementia|Cognitive Impairment
Interventions: OTHER: 5-Cog Paradigm (5-Cog battery coupled with clinical decision tool)|OTHER: Enhanced usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Dose Escalation and Combination Immunotherapy Study to Evaluate BMS-986226 Alone or in Combination With Nivolumab or Ipilimumab in Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Cancer|Tumors|Neoplasm|Malignancy
Interventions: DRUG: BMS-986226|BIOLOGICAL: Nivolumab|BIOLOGICAL: Ipilimumab|BIOLOGICAL: Tetanus Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastrodia and Uncaria Recipe in Treating Stage-one Hypertension: an Evidence-based Optimization Study
Status: UNKNOWN
Conditions: Hypertension
Interventions: DRUG: Gastrodia and Uncaria granule|DRUG: Placebo of Gastrodia and Uncaria granule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Proparacaine and Mydriatic Eye Drops
Status: TERMINATED
Conditions: Pain|Retinopathy of Prematurity
Interventions: DRUG: Proparacaine Hydrochloride Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Tirzepatide (LY3298176) in Participants With Impaired Kidney Function
Status: COMPLETED
Conditions: Renal Insufficiency|End Stage Renal Disease
Interventions: DRUG: Tirzepatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Metformin, Neo-adjuvant Temozolomide and Hypo- Accelerated Radiotherapy Followed by Adjuvant TMZ in Patients With GBM
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of HPV Vaccine On The Prevalence Of HPV In Norway
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia|Cervical Cancer|Oropharyngeal Cancer
Interventions: PROCEDURE: Self sample from vagina|PROCEDURE: Self sample from the oral cavity|OTHER: Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Red-fleshed Apple as a Novel Anthocyanin-biofortified Food to Improve Cardiometabolic Risk Factors.
Status: UNKNOWN
Conditions: High LDL-cholesterol Levels
Interventions: OTHER: Redlove Apple intervention|OTHER: Green Apple intervention|OTHER: Aronia drink intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Maternal-foetal Transmission of SARS-Cov-2
Status: COMPLETED
Conditions: Maternal Fetal Infection Transmission|COVID-19|SARS-CoV 2
Interventions: DIAGNOSTIC_TEST: Diagnosis of SARS-Cov2 by RT-PCR and : IgG, Ig M serologies in the amniotoc fluid, the blood cord and the placenta
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Functional and Ultrasound Guided Resection of Glioblastoma
Status: RECRUITING
Conditions: Glioma Glioblastoma Multiforme
Interventions: OTHER: Standard of Care|OTHER: Additional pre- and intra-operative imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Psychological Impact of Mindfulness Intervention to Anterior Cruciate Ligament Reconstruction
Status: RECRUITING
Conditions: Anterior Cruciate Ligament (Acl) Reconstruction
Interventions: BEHAVIORAL: mindfulness practice of body scan|BEHAVIORAL: listening to light music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single-sex Controlled Human Schistosomiasis Infection: Safety and Dose Finding
Status: COMPLETED
Conditions: Schistosomiasis|Schistosoma Mansoni
Interventions: BIOLOGICAL: male Schistosoma mansoni cercariae
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Combination Therapy With Ra-223 and Enzalutamide
Status: UNKNOWN
Conditions: Castration-resistant Prostate Cancer|Bone Metastases
Interventions: DRUG: Ra-223 in combination with enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of SARS-CoV-2 mRNA Vaccine (SYS6006) in Chinese Healthy Participants Aged 18 Years or More
Status: ACTIVE_NOT_RECRUITING
Conditions: SARS-CoV-2 Infection
Interventions: BIOLOGICAL: SYS6006 20 μg|BIOLOGICAL: SYS6006 30 μg|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Strengthening Mental Health Care in Chronic Care Patients With Hypertension. A Cluster Randomised Control Trial
Status: COMPLETED
Conditions: Depression|Hypertension
Interventions: BEHAVIORAL: PC101+Mental Health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Early Intermittent Intensive Insulin Therapy as an Effective Treatment of Type 2 Diabetes (RESET-IT Main Trial)
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Metformin alone|DRUG: Metformin + Intermittent Insulin Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Open-label Study for E7040 in Japanese Subjects With Hypervascular Tumor and Subjects With Arteriovenous Malformation
Status: COMPLETED
Conditions: Hypervascular Tumor and Arteriovenous Malformation
Interventions: DEVICE: E7040
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Causal Role of Prefrontal Control in Decision-making in Patients With Anhedonia
Status: COMPLETED
Conditions: Major Depressive Disorder|Anhedonia
Interventions: DEVICE: Cross-frequency transcranial alternating current stimulation via the NeuroConn Direct Current Stimulator Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Intraperitoneal and Intravenous Paclitaxel Plus Apatinib and S-1 Conversion Therapy for Gastric Cancer With Positive Exfoliative Cancer Cells
Status: UNKNOWN
Conditions: Gastric Cancer With Positive Exfoliative Cancer Cells
Interventions: DRUG: apatinib|DRUG: paclitaxel|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Periostin-guided Withdrawal of Inhaled Corticosteroids in Patients With Non-eosinophilic Asthma
Status: UNKNOWN
Conditions: Asthma
Interventions: DRUG: Tapering of inhaled corticosteroid (ICS) treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetic Evaluation of an Intensified and Decreasing Dosing Regimen of Mycophenolate Sodium in Combination With Tacrolimus Post Kidney Transplant: The Myfortic Study
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: mycophénolate acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In Vitro/in Vivo Correlation (IVIVC) for Oral Slow Release (SR) Tablets Pramipexole in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: High fat, high caloric meal|DRUG: Pramipexole IR tablets|DRUG: Pramipexole SR C|DRUG: Pramipexole SR C2|DRUG: Pramipexole SR C2A|DRUG: Pramipexole SR C2B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-CD38 Antibody With KRAS Vaccine and Anti-PD-1 Antibody in Subjects With Pancreatic Ductal Adenocarcinoma and Refractory Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma|Refractory Non-Small Cell Lung Cancer
Interventions: DRUG: Daratumumab|BIOLOGICAL: KRAS vaccine|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and the Effects of Ixodes Ricinus-Contact Phase Inhibitor (Ir-CPI) in Adult Patients With Spontaneous Intracerebral Haemorrhage
Status: RECRUITING
Conditions: Intracerebral Hemorrhage
Interventions: DRUG: Ir-CPI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CM336 in Patients With Relapsed or Refractory Multiple Myeloma
Status: NOT_YET_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: CM336_group 1|DRUG: CM336_group 2a|DRUG: CM336_group 2b|DRUG: CM336_group 3a|DRUG: CM336_group 3b|DRUG: CM336_group 4a|DRUG: CM336_group 4b|DRUG: CM336_group 5|DRUG: CM336_group 6a|DRUG: CM336_group 6b|DRUG: CM336_group 7|DRUG: CM336_group 8a|DRUG: CM336_group 8b|DRUG: CM336_group 9|DRUG: CM336_RP2D
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization of Natural IL-6 Inhibition in Healthy Individuals
Status: RECRUITING
Conditions: Autoantibodies|Interleukin-6
Interventions: OTHER: Oral Glucose Tolerance Test|OTHER: Cycling test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Clinical Research of CAR T Cells Targeting CEA Positive Cancer
Status: UNKNOWN
Conditions: Lung Cancer|Colorectal Cancer|Gastric Cancer|Breast Cancer|Pancreatic Cancer
Interventions: BIOLOGICAL: Anti-CEA-CAR T
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Utility of Pharmacogenomics of Psychotropic Medications
Status: WITHDRAWN
Conditions: Psychiatric Disorders|Pain
Interventions: DRUG: Genetically-guided treatment with FDA-approved psychotropic drugs|DRUG: Treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nasal Septal Flap for Donor Site Reconstruction
Status: COMPLETED
Conditions: Nasal Septum Perforation
Interventions: OTHER: Biodesign™ SIS graft|OTHER: Doyle silastic sheet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Remote Pulmonary Function Testing in Amyotrophic Lateral Sclerosis (Pilot)
Status: COMPLETED
Conditions: ALS
Interventions: DEVICE: remote pulmonary function testing|DEVICE: standard pulmonary function testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic Conditions
Status: COMPLETED
Conditions: Sickle Cell Disease|Chronic Kidney Diseases|Systemic Lupus Erythematosus|Childhood Cancer|Inflammatory Bowel Diseases|Stem Cell Transplant|Organ Transplant|Diabetes Mellitus, Type 1|Cystic Fibrosis
Interventions: BEHAVIORAL: PiCASO Intervention Group|BEHAVIORAL: Sham Comparator: Attention Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acute Effect of Pulmonary Desufflation on Cardiac Performance in COPD Patients
Status: COMPLETED
Conditions: COPD|Hyperinflation|Right Cardiac Failure
Interventions: DRUG: Indacaterol Fumarate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE