pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase 1 Clinical Trial With Controlled Human Malaria Infection (CHMI) to Evaluate the Safety and Efficacy of the Plasmodium Falciparum Vaccine Candidate FMP012 Administered Intramuscularly With AS01B Adjuvant System in Healthy Malaria-Naïve Adults
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: FMP012 with AS01B adjuvant system|OTHER: P falciparum Controlled Human Malaria Infection (CHMI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Coexistence of Atherosclerotic Intracranial Arterial Stenosis With Intracranial Aneurysms
Status: UNKNOWN
Conditions: Atherosclerotic Intracranial Arterial Stenosis With Intracranial Aneurysms
Interventions: DRUG: conservative treatment|PROCEDURE: Aneurysms clipping|PROCEDURE: Interventional embolization forAneurysms|PROCEDURE: stenting for stenosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: STENOVA - A Study to Evaluate Safety, Tolerability, PK and PD of AGMB-129 in Patients With Fibrostenotic Crohn's Disease
Status: RECRUITING
Conditions: Fibrostenotic Crohn's Disease
Interventions: DRUG: AGMB-129|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficiency for Three Different Aligning Archwires During Initial Orthodontic Leveling
Status: COMPLETED
Conditions: Dental Malocclusion|Dental Crowding
Interventions: DEVICE: fixed orthodontic appliance and arch wires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of IV Recombinant Tissue Plasminogen Activator (rtPA) vs. Primary Endovascular Therapy for Acute Ischemic Stroke
Status: TERMINATED
Conditions: Stroke|Ischemic Stroke
Interventions: DRUG: Intravenous Thrombolysis|DEVICE: Endovascular Arterial Reperfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Capsule Endoscopy With PillCam® COLON 2 in Visualization of the Colon
Status: COMPLETED
Conditions: CRC Screening
Interventions: DEVICE: PillCam® COLON 2 procedure|PROCEDURE: Colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: A Phase II Study of Bevacizumab and Bortezomib in Patients With Relapsed/Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of MDZ on Movement During UIA Clipping
Status: RECRUITING
Conditions: Intraoperative Movement
Interventions: DRUG: Midazolam|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Magnesium Sulfate as an Adjuvant to Caudal Bupivacaine in Lower Abdominal Surgeries in Paediatrics.
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: Magnesium SO4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Psychotherapy for Psychosis, Adverse Events, and Substance Misuse
Status: COMPLETED
Conditions: Psychotic Disorders|Stress Disorders, Traumatic|Substance Use
Interventions: BEHAVIORAL: Prolonged exposure (PE)+ therapy|OTHER: Treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "Study of Halitosis in Patients With Advanced Chronic Periodontitis"
Status: COMPLETED
Conditions: Periodontal Disease|Halitosis|Periodontitis
Interventions: PROCEDURE: Scaling and Root Planning (SRP)|PROCEDURE: Full Mouth Scaling (FMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Unilateral Versus Bilateral Stents for Bismuth Type II and III Malignant Hilar Strictures
Status: UNKNOWN
Conditions: Cholangiocarcinoma
Interventions: PROCEDURE: ERCP plus one biliary stent|PROCEDURE: ERCP plus two biliary stents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Expressive Writing and Compassionate Letter Writing on Emotional Distress Intolerance
Status: COMPLETED
Conditions: Distress Intolerance
Interventions: OTHER: Self-compassionate writing intervention|OTHER: Expressive writing intervention|OTHER: Control writing task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Well-being in Cancer Patients With Neuropathy During COVID-19 Who Participated in Prior Clinical Trials
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19 Infection|Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm|Neuropathy
Interventions: OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rosuvastatin in Treating Patients With Stage I or Stage II Colon Cancer That Was Removed By Surgery
Status: TERMINATED
Conditions: Colorectal Cancer|Precancerous Condition
Interventions: DRUG: rosuvastatin|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maintenance Low Dose 5'-Azacitidine Post T Cell Depleted Allogeneic Stem Cell Transplantation for Patients With Myelodysplastic Syndrome and Acute Myelogenous Leukemia With High Risk for Post-Transplant Relapse
Status: COMPLETED
Conditions: Myelodysplastic Syndromes (MDS)|Acute Myelogenous Leukemia (AML)
Interventions: DRUG: low dose 5'-azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fermented Milk Product With Probiotic and Its Impact on Mood of Patients With Treatment Resistant Depression
Status: COMPLETED
Conditions: Depression
Interventions: DIETARY_SUPPLEMENT: BioKefir|DIETARY_SUPPLEMENT: Non-fermented milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy and Safety of TQB3616 in Combination With Fulvestrant Versus Placebo in Combination With Fulvestrant in Previously Untreated Hormone-receptor (HR)-Positive, Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Advanced Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: HR-positive, HER2-negative Breast Neoplasms
Interventions: DRUG: TQB3616 capsule|DRUG: Placebo|DRUG: Fulvestrant injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Indirect Bonding Accuracy of 3D Printed Digital Transfer Trays
Status: RECRUITING
Conditions: Orthodontics|Bracket Bonding|Indirect Bonding|Digital Indirect Bonding Transfer Tray|Accuracy of Bracket Positioning
Interventions: OTHER: Indirect bonding with two different digital bracket bonding transfer tray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: An Integrated Intervention Using a Pill Ingestible Sensor System
Status: NOT_YET_RECRUITING
Conditions: HIV/AIDS|Medication Adherence|Social Determinants of Health (SDOH)
Interventions: BEHAVIORAL: ISS-SBDOH arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Double-blind Placebo-controlled 2-part Study Assessing the Safety, Tolerability and PK of AZD1386 in Healthy Volunteers
Status: TERMINATED
Conditions: Healthy Volunteers
Interventions: DRUG: AZD1386|DRUG: Placebo for AZD1386|DRUG: Naproxen|DRUG: Placebo for Naproxen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 1, Single-Ascending-Dose Study of BT051 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: BT051 100mg|DRUG: BT051 300mg|DRUG: BT051 700mg|DRUG: BT051 1500mg|DRUG: BT051 3500mg|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Comparison of LY2963016 to a Basal Insulin After a Single Dose in Healthy Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: LY2963016|DRUG: Lantus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof-of-Concept Trial of a Positive Psychology Intervention for Caregivers of Patients Undergoing HSCT
Status: COMPLETED
Conditions: Caregiver|Hematologic Malignancy
Interventions: BEHAVIORAL: Positive Psychology Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Is There a Desensitization During Sleep After Exposure to a Violent Verbal Input ?
Status: UNKNOWN
Conditions: Verbal Abuse
Interventions: BEHAVIORAL: Watching Video-clip 1|BEHAVIORAL: Watching Video-clip 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Performances and Safety of MuCopilot, a Digital Tool for the Unsupervised Objective Assessment of Cystic Fibrosis
Status: NOT_YET_RECRUITING
Conditions: Cystic Fibrosis
Interventions: DEVICE: MuCopilot mobile application
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Observational STudy to Evaluate the EFfectiveness of OnLife® in Improving CIPN in Patients With Colon or Breast Cancer After End of Adj. Therapy
Status: COMPLETED
Conditions: CIPN in Adjuvant Colon Cancer Patients|CIPN in Adjuvant Breast Cancer Patients
Interventions: DIETARY_SUPPLEMENT: OnLife
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: EUS-guided Transmural Drainage of Walled-off Pancreatic Necrosis: Plastic vs Metallic Protesis.
Status: COMPLETED
Conditions: Pancreas Necrosis|Pancreatic Collection
Interventions: DEVICE: WOPN TRANSMURAL DRAINAGE: PLASTIC STENT|DEVICE: WOPN TRANSMURAL DRAINAGE: METALLIC STENT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Effectiveness and Safety of Extended Release (ER) Tramadol Hydrochloride (HCl)/Acetaminophen With Immediate Release (IR) Tramadol HCl/Acetaminophen in Participants With Moderate to Severe Postoperative Pain
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Tramadol HCl/Acetaminophen ER|DRUG: Tramadol HCl/Acetaminophen IR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Olanzapine for Prevention of Chemotherapy-induced Nausea and Vomiting in Children: A Multi-Centre Feasibility Study
Status: COMPLETED
Conditions: Chemotherapy-induced Nausea and Vomiting
Interventions: DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lidocaine Infusion in Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Lidocaine Hydrochloride|DRUG: Saline Solution for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effects of Community-based Caring Contact on Post-discharge Young Adults With Self-harm
Status: UNKNOWN
Conditions: Self Inflicted Injury|Suicide and Self Inflicted Injury
Interventions: BEHAVIORAL: Volunteer support|OTHER: Mobile app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intracameral Levofloxacin (0.5%) vs Intracameral Cefuroxime
Status: UNKNOWN
Conditions: Endophthalmitis Postoperative
Interventions: DRUG: Levofloxacin Ophthalmic|DRUG: Cefuroxime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Avastin (Bevacizumab) in Combination Chemotherapy in Patients With Metastatic Cancer of the Colon or Rectum
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Bevacizumab [Avastin]|DRUG: Capecitabine|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ)
Status: ENROLLING_BY_INVITATION
Conditions: Medication-related Osteonecrosis of the Jaw|Bisphosphonate-related Osteonecrosis of the Jaw|Avascular Necrosis
Interventions: DRUG: Pentoxifylline|DRUG: Placebo|DRUG: Tocopherol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
Status: NOT_YET_RECRUITING
Conditions: Venous Thromboembolism|Postpartum Period|Aspirin|Low Molecular Weight Heparin
Interventions: DRUG: Aspirin|DRUG: Low-molecular-weight heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Dental Brushing for Preventing Ventilator-Associated Pneumonia
Status: UNKNOWN
Conditions: Ventilator-Associated Pneumonia|Nosocomial Pneumonia|Pneumonia
Interventions: PROCEDURE: Toothbrushing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: GW873140 In Combination With Kaletra In HIV Infected Subjects
Status: TERMINATED
Conditions: Infection, Human Immunodeficiency Virus I|HIV Infection
Interventions: DRUG: GW873140|DRUG: Kaletra (lopinavir/ritonavir)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Value of Lateral Release in Reconstruction of the Diaphragmatic Hiatus Hernia
Status: ACTIVE_NOT_RECRUITING
Conditions: Paraesophageal Hernia
Interventions: PROCEDURE: Crura plastic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin C Supplementation in Patients With Primary Hypothyroidism
Status: RECRUITING
Conditions: Hypothyroidism|Primary Hypothyroidism|Vitamin C Deficiency
Interventions: DRUG: Vitamin C|DRUG: Oral Rehydration Salt Formulations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Outcomes Following Phacoemulsification With 1.8 & 2.2mm Incision: Randomized Clinical Trial
Status: UNKNOWN
Conditions: Cataract
Interventions: PROCEDURE: Microcoaxial Phacoemulsification|PROCEDURE: Microcoaxial Phacoemulsification|PROCEDURE: Microcoaxial Phacoemulsification|PROCEDURE: Microcoaxial Phacoemulsification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Resynchronization and Iodine Meta-Iodobenzylguanidine (MIBG) Imaging
Status: TERMINATED
Conditions: Congestive Heart Failure
Interventions: DRUG: 123 iodine metaiodobenzylguanidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transorb™ Self-Gripping Resorbable Mesh in High-risk Subjects Undergoing Open Repair of Ventral Hernia
Status: RECRUITING
Conditions: Hernia|Hernia, Ventral|Hernia, Abdominal|Hernia Abdominal Wall
Interventions: DEVICE: Transorb™ Self-Gripping Resorbable Mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of the Arctic Front Cryoablation Balloon for the Treatment of Paroxysmal Atrial Fibrillation
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: Arctic Front® Cryoablation Catheter|DRUG: Flecainide or Sotalol or Propafenone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comorbid Esophageal Disorders in IBS Patients
Status: UNKNOWN
Conditions: GERD|Non-erosive Reflux Disease|Functional Esophageal Disorders|Irritable Bowel Syndrome
Interventions: DIAGNOSTIC_TEST: Upper endoscopy, esophageal manometry, 24-hour pH monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study to Test Bioequivalence Between One Test Formulation of Ibuprofen and Two Reference Treatments
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Ibuprofen|DRUG: Ibuprofen|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Venous Phase Dual Energy CT in Patients Suspected for Pulmonary Embolism.
Status: UNKNOWN
Conditions: Pulmonary Embolus/Emboli|Thromboembolism, Pulmonary
Interventions: DIAGNOSTIC_TEST: Dual energy / spectral portal venous chest computed tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: T-DM1 and Non-pegylated Liposomal Doxorubicin in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab and non-pegylated liposomal doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HeartFlowNXT - HeartFlow Analysis of Coronary Blood Flow Using Coronary CT Angiography
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: ICA (Invasive Coronary Angiography)|PROCEDURE: FFR (Fractional Flow Reserve)|PROCEDURE: cCTA (coronary computed tomography angiography)|OTHER: FFRct Analysis (Fractional Flow Reserve Computed Tomography)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Validation Study of the Feasibility of an Integrated Diagnostic System of Anatomo-pathological Lesions - Including Rejections - Appearing in Renal Grafts in the First Year of Transplant for Applicability in Routine Clinical Practice : KTD Innov-2 Study
Status: UNKNOWN
Conditions: Kidney Transplant
Interventions: DIAGNOSTIC_TEST: KTD Innov-2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacological Interaction Between Clonidine and Methylenedioxymethamphetamine (MDMA)
Status: COMPLETED
Conditions: Mood Disorder|Substance-Related Disorders|Amphetamine-Related Disorders
Interventions: DRUG: 3,4-Methylenedioxymethamphetamine|DRUG: Clonidine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Latiglutenase as a Treatment for Celiac Disease
Status: COMPLETED
Conditions: Celiac Disease
Interventions: DRUG: Latiglutenase|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Manufacturing Processes for AIR OPTIX® COLORS Contact Lens
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Lotrafilcon B contact lens with color, automated|DEVICE: Lotrafilcon B contact lens with color, semi-automated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Efficacy, Safety and Tolerability of Serelaxin When Added to Standard Therapy in AHF
Status: COMPLETED
Conditions: Acute Heart Failure
Interventions: DRUG: RLX030|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Tolerability of CLZ-2002 in Patients With Charcot-Marie Tooth Disease.
Status: ACTIVE_NOT_RECRUITING
Conditions: Charcot Marie Tooth Disease, Type 1
Interventions: DRUG: CLZ-2002
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STOP DIABETES - Knowledge-based Solutions
Status: RECRUITING
Conditions: Type2 Diabetes|Life Style|Diet Habit|Physical Activity|Empowerment
Interventions: BEHAVIORAL: Digital lifestyle intervention group|BEHAVIORAL: Combined digital and face-to-face lifestyle intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study Using Gene Therapy for Critical Limb Ischemia
Status: COMPLETED
Conditions: Arterial Occlusive Disease|Ulcers|Ischemia|Peripheral Vascular Disease
Interventions: GENETIC: NL003|GENETIC: NL003|GENETIC: NL003|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mucosal Pressure of the Laryngeal Mask Airway Supreme Versus the i-Gel in Paralyzed Anesthetized Female Patients
Status: COMPLETED
Conditions: Device Induced Injury|Necrosis, Pressure|Complication of Device Insertion|Airway Morbidity
Interventions: DEVICE: Laryngeal Mask Airway Supreme|DEVICE: i-Gel extraglottic airway device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of BCRP Q141K on Allopurinol Pharmacokinetics and Dynamics
Status: COMPLETED
Conditions: Chronic Gout|Hyperuricemia
Interventions: DRUG: Allopurinol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effectiveness of Blended Forensic Ambulant Systemic Therapy
Status: RECRUITING
Conditions: Conduct Disorder|Antisocial Behavior|Behavioral Disorder
Interventions: BEHAVIORAL: FASTb|BEHAVIORAL: FASTr
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of RIC on 2,3-BPG in Erythrocyte (RIC-BPG)
Status: UNKNOWN
Conditions: 2,3-Bisphosphoglycerate
Interventions: DEVICE: remote ischemic conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Peripherally Inserted Central Catheter Insertion Site and Complication Rate in Neonates
Status: RECRUITING
Conditions: Catheterization, Peripheral
Interventions: DEVICE: Peripherally Inserted Central Venous Cather (PICC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Cognitive - Affective - Addictive Based Intervention to Decrease Food Craving in Obese Patients.
Status: UNKNOWN
Conditions: Obesity|Craving|Cognitive Behavioral Therapy|Cognitive Remediation Therapy|Addiction
Interventions: BEHAVIORAL: Cognitive Remediation Therapy (CRT)|BEHAVIORAL: Emotional Skills Training (EST)|BEHAVIORAL: Cognitive Behavioral Therapy|PROCEDURE: Multidisciplinary outpatient program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment of The Efficacy of Intratympanic Platelet Rich Plasma for Treatment of Sensorineural Hearing Loss.
Status: NOT_YET_RECRUITING
Conditions: Hearing Loss, Sudden|Hearing Loss, Sensorineural|Hearing Loss
Interventions: BIOLOGICAL: Platelet Rich Plasma|DRUG: local anesthesia in external auditory canal|PROCEDURE: Intratympanic Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MDT-2113 Drug-Eluting Balloon vs. Standard PTA for the Treatment of Atherosclerotic Lesions in the Superficial Femoral Artery and/or Proximal Popliteal Artery
Status: COMPLETED
Conditions: Femoral Artery Stenosis|Popliteal Artery Stenosis|Femoral Artery Occlusion|Popliteal Artery Occlusion
Interventions: DEVICE: MDT-2113 Drug-Eluting Balloon|DEVICE: Standard angioplasty balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Phe Fluctuation in PKU Pts Treated With PKU GOLIKE Versus Standard Amino Acid Protein Substitute.
Status: COMPLETED
Conditions: Phenylketonurias
Interventions: DIETARY_SUPPLEMENT: PKU GOLIKE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Warm Water Versus Room Temperature Water Immersion Colonoscopy
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: PROCEDURE: Warm Water Immersion Colonoscopy|PROCEDURE: Cool Water Immersion Colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Nitric Oxide Releasing Sinus Irrigation (NOSi) to Treat Recalcitrant Chronic Rhinosinusitis (RCRS)
Status: COMPLETED
Conditions: Chronic Sinusitis
Interventions: DRUG: Nitric Oxide|DRUG: Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laser Therapy for Treatment of Urogenital Symptoms in Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Genitourinary System; Disorder, Female|Burning Vagina|Dyspareunia|Irritation; Vagina|Menopause Related Conditions|Urinary Incontinence|Urinary Bladder, Overactive|Urinary Tract Infections|Stress Urinary Incontinence
Interventions: DEVICE: fCO2 Laser Therapy Group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of a Nutritional Supplement Product Containing Cactus Fruit Juice (Nopalea) on C-Reactive Protein
Status: COMPLETED
Conditions: Inflammation
Interventions: DIETARY_SUPPLEMENT: NOPALEA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Molecularly Tailored Therapy for Pancreas Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Gem-OX|DRUG: Gem-5FU|DRUG: Gem-Tax|DRUG: Modified FOLFOX-6|DRUG: Ox-Tax|DRUG: FOLFIRI|DRUG: Tax-Iri
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Urinary pH Changes on an Investigational Compound in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: LY2140023|DRUG: Ammonium chloride|DRUG: Sodium bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Epiretinal Membrane and Cystoid Macular Oedema Post-cataract Surgery
Status: COMPLETED
Conditions: Pseudophakic Cystoid Macular Oedema|Epiretinal Membrane
Interventions: DRUG: topical (eye drop) anti-inflammatories
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of NANO-PSO on Cognition in Older Adults with Mild to Moderate Cognitive Impairment
Status: NOT_YET_RECRUITING
Conditions: Omega 5|NANO-PSO|Cognition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Two Different Toothpastes for Clinical Management of Extrinsic Stains.
Status: COMPLETED
Conditions: Extrinsic Staining of Tooth - Medication
Interventions: OTHER: Blanx Black Toothpaste|OTHER: Colgate Sensation White
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of an Interprofessional Shared Decision-making and Goal-setting Decision Aid for Patients With Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: OTHER: Shared decision-making aid|OTHER: Generic hard copy diabetes resources|OTHER: Generic online diabetes resources
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: LifeSeal™ Pilot Study in Subjects Undergoing Circular Stapled Anastomosis Created Within 10 cm of the Anal Verge
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DEVICE: LifeSeal™ Kit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HYDROcortisone Versus Placebo for Severe HospItal-acquired Pneumonia in Intensive Care Patients: the HYDRO-SHIP Study
Status: RECRUITING
Conditions: Healthcare-Associated Pneumonia|Ventilator Associated Pneumonia
Interventions: DRUG: Hydrocortisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Red Cell Distribution Width,,NT-proBNP and cTnT in Acute Myocardial Infraction Patient
Status: NOT_YET_RECRUITING
Conditions: Myocardial Infarction
Interventions: DIAGNOSTIC_TEST: (CBC) ,(NT-proBNP) ,(cTnT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Buffered Hypertonic Saline(BHS)Nasal Irrigation in Allergic Rhinitis (AR) Children
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: NSS nasal irrigation salt|DRUG: BHS nasal irrigation salt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Golimumab and Apalutamide for the Treatment of Castration-Resistant Prostate Cancer, TRAMP Study
Status: RECRUITING
Conditions: Castration-Resistant Prostate Carcinoma|Prostate Adenocarcinoma
Interventions: DRUG: Apalutamide|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Golimumab|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: PSMA PET Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Norepinephrine Plus Dobutamine Versus Epinephrine Alone for the Management of Septic Shock
Status: COMPLETED
Conditions: Septic Shock|Severe Sepsis|Infections
Interventions: DRUG: norepinephrine and dobutamine|DRUG: epinephrine plus placebo of dobutamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Extension of Efgartigimod in Adults With Post-COVID-19 POTS
Status: ACTIVE_NOT_RECRUITING
Conditions: Post-COVID Postural Orthostatic Tachycardia Syndrome Postural Orthostatic Tachycardia Syndrome
Interventions: DRUG: Efgartigimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Albumin Supplementation on the Inflammatory and Oxidative Stress Markers in Septic Patients
Status: UNKNOWN
Conditions: Albumin Supplementation|Albumin Therapy|Sepsis
Interventions: DRUG: Human albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Novel Behavior Change Intervention for Posttraumatic Stress
Status: COMPLETED
Conditions: PTSD
Interventions: BEHAVIORAL: Safety Behavior Elimination for Traumatic Stress (SBETS)|BEHAVIORAL: Modifiable Behavior Intervention (MoBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Water-based Aerobic and Combined Training in Elderly Woman
Status: UNKNOWN
Conditions: Elderly Women
Interventions: BEHAVIORAL: Water-based aerobic training|BEHAVIORAL: Water-based aerobic and combined training|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: NeoMend ProGEL™ Pleural Air Leak Sealant Post-Approval Study
Status: COMPLETED
Conditions: Lung Cancer|Lung Tumor
Interventions: OTHER: Control|DEVICE: ProGEL Pleural Air Leak Sealant with standard surgical closure|DEVICE: ProGEL Pleural Air Leak Sealant without standard surgical closure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cycling Exercise With Functional Electrical Stimulation Improves Postural Control in Stroke Patients
Status: COMPLETED
Conditions: Postural Control
Interventions: DEVICE: Cycling Exercise with Functional Electrical Stimulation|DEVICE: cycling exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Improving the Reproductive Outcome of Poor Quality Ova by Injection of Autologous Somatic Mitochondria
Status: WITHDRAWN
Conditions: Low Ovarian Reserve|Poor Quality Oocytes
Interventions: PROCEDURE: Injection of an autologous mitochondria to the oocyte.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Cabozantinib as Monotherapy or in Combination With Nivolumab in Patients With Advanced or Metastatic Renal Cell Carcinoma Under Real-life Clinical Setting in 1st Line Treatment.
Status: RECRUITING
Conditions: Advanced Renal Cell Carcinoma|Metastatic Renal Cell Carcinoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluate Safety, Tolerability and PK of HLX55 in Patients With Advanced Solid Tumors With Different cMET Status
Status: UNKNOWN
Conditions: Solid Tumor, Adult
Interventions: DRUG: HLX55
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of LM103 Injection in the Treatment of Advanced Solid Tumors
Status: RECRUITING
Conditions: Melanoma|Non Small Cell Lung Cancer|Cervical Carcinoma
Interventions: DRUG: Autologous tumor infiltrating lymphocytes (TILs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The DBCG Proton Trial: Photon Versus Proton Radiation Therapy for Early Breast Cancer
Status: RECRUITING
Conditions: Early Breast Cancer|Radiation Associated Cardiac Failure
Interventions: RADIATION: Proton versus photon radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Structural Outcome of Conventional Versus Accelerated Corneal Collagen Cross-linking (CXL).
Status: UNKNOWN
Conditions: Keratoconus|Corneal Ectasia
Interventions: DEVICE: UV-X 1000 (3 mW/cm²)|PROCEDURE: UV-X 2000 (9 mW/cm²)|DRUG: riboflavin with hydroxypropyl methylcellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-response of Inhaled Formoterol Using Methacholine Challenge as a Bioassay
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: formoterol|DRUG: formoterol|DEVICE: Dry Powder Inhaler (Twisthaler)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Impact of a Treatment With Angiotensin Receptor Blocker on Outcome After Acute Kidney Injury in Patients Discharged From the ICU.
Status: RECRUITING
Conditions: Acute Kidney Injury
Interventions: DRUG: IRBESARTAN, tablet, 150 mg|DRUG: Placebo, tablet, 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety, Tolerability, and Pharmacokinetics of NUV001 Administered Orally to Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: NUV001 active cohort 1|DRUG: NUV001 active cohort 2|DRUG: NUV001 active cohort 3|DRUG: NUV001 active cohort 4|DRUG: NUV001 placebo cohort 1|DRUG: NUV001 placebo cohort 2|DRUG: NUV001 placebo cohort 3|DRUG: NUV001 placebo cohort 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Drug Combination Therapy of Isotretinoin and Some Antifungal Drugs as A Potential Aerosol Therapy for COVID-19 : An Innovative Therapeutic Approach COVID-19
Status: UNKNOWN
Conditions: Covid19
Interventions: DRUG: Drug: Isotretinoin(Aerosolized 13 cis retinoic acid) plus Aerosolized Itraconazole|DRUG: Drug: Isotretinoin(Aerosolized 13 cis retinoic acid)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Medication Timing Adjustment on the Effect of Novel Hormonal Therapy
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Receive Abiraterone plus prednisone/Enzalutamide/Apalutamide/Rezvilutamide in the evening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodal Assessment of Cannabinoid Target Engagement in Adults With Obsessive-Compulsive Disorder
Status: WITHDRAWN
Conditions: Obsessive-Compulsive Disorder
Interventions: DRUG: Nabilone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Integrated Approach to Health, Wellbeing, and Productivity at Work
Status: RECRUITING
Conditions: Musculoskeletal Disorder|Mental Health Issue|Work-related Illness|Safety Issues|Work Environment Adverse Effects
Interventions: BEHAVIORAL: Integrated Approach to Health, Wellbeing, and Productivity at Work (ITASPA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Randomized-Controlled Trial to Increase the Uptake of LARCs in Cameroon
Status: ACTIVE_NOT_RECRUITING
Conditions: Contraception|Contraception Behavior|Contraceptive Usage|Contraceptive Method Switching
Interventions: BEHAVIORAL: Price discounts for SARCs|BEHAVIORAL: Price discounts for LARCs|BEHAVIORAL: Sequential vs. simultaneous recommendations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Identification of Nerves Using Fluorescein Sodium
Status: NOT_YET_RECRUITING
Conditions: Pleomorphic Adenoma of the Parotid|Warthin Tumor|Head and Neck Disorder
Interventions: DRUG: Fluorescein Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Erlotinib (Tarceva) in Participants With Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reversing the Effects of 2% Lidocaine
Status: COMPLETED
Conditions: Soft Tissue Anaesthesia
Interventions: DRUG: Phentolamine mesylate|DRUG: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Misoprostol and Oxytocin in UnijectTM for Postpartum Hemorrhage (PPH) Prevention in Mali
Status: WITHDRAWN
Conditions: Postpartum Hemorrhage
Interventions: DRUG: misprostol|DEVICE: UnijectTM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of CharcoCaps® (Activated Charcoal) vs. Placebo on Intestinal Gas Production
Status: COMPLETED
Conditions: Intestinal Gas
Interventions: DIETARY_SUPPLEMENT: Charcocaps|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Head Elevated Position and Hyper-angulated Video-laryngoscope Guided Intubation
Status: NOT_YET_RECRUITING
Conditions: Intubation; Difficult or Failed
Interventions: PROCEDURE: back-up head elevated position|PROCEDURE: neutral position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Plant Protein Supplementation Within a Healthy Lifestyle Modulates Plasma Circulating Amino Acids and Improves the Health Status of Overweight Individuals
Status: COMPLETED
Conditions: Obesity|Metabolic Syndrome|Metabolic Disorder|Inflammation|Immune System and Related Disorders
Interventions: DIETARY_SUPPLEMENT: Mediterranean diet supplement with 20 g / day of hemp protein.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: EEG/Event-related Brain Potential Risk Markers as Predictors and Outcomes of SUD Treatment in Adolescents
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: BEHAVIORAL: Bias retraining|BEHAVIORAL: Sham retraining
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study to Evaluate The Effect of Ketoconazole on the Pharmacokinetics of Tivozanib in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: tivozanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Evaluation of Thulium Laser Alone or in Combination With Broad Band Light for Treatment of Dermatologic Conditions
Status: COMPLETED
Conditions: Dermatology/Skin - Other
Interventions: DEVICE: Thulium Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of CBP-201 in Patients With Moderate to Severe Persistent Asthma With Type 2 Inflammation
Status: COMPLETED
Conditions: Moderate to Severe Persistent Asthma
Interventions: DRUG: CBP-201|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Utility Quadriceps Magnetic Stimulation in COPD (Chronic Obstructive Pulmonary Disease) Patients After Hospital Exacerbation
Status: UNKNOWN
Conditions: COPD|COPD Exacerbation
Interventions: DEVICE: Repetitive magnetic stimulation of the quadriceps muscle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of a Customized Insole to Provide Relief From Heel Pain Due to Plantar Fasciitis or General Heel Pain When Used in Footwear Over a Period of Four Weeks
Status: COMPLETED
Conditions: Foot Orthoses
Interventions: DEVICE: BPI1000013
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers
Status: RECRUITING
Conditions: Vascular Reactivity|Serum Biomarkers
Interventions: DEVICE: Standardized Electronic Research Cigarette|DEVICE: Nicotine Research Cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of CROWN in Repair and Maintenance of the Intestinal Mucosa in Patients With CD Receiving Anti-TNF Therapy
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: DRUG: CROWN|DRUG: CROWN Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT