pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Imaging of Pathologic Fibrosis Using 68Ga-FAP-2286
Status: RECRUITING
Conditions: Liver Fibrosis|Pulmonary Fibrosis|Myocardial Fibrosis
Interventions: DRUG: 68Ga-FAP-2286|PROCEDURE: Positron Emission Tomography (PET)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of a Multiple Micronutrient-Fortified Lipid-Based Nutrient Supplement for Children Under Two in Cambodia
Status: UNKNOWN
Conditions: Child Malnutrition
Interventions: DIETARY_SUPPLEMENT: LNS|DIETARY_SUPPLEMENT: Corn-soy blend ++ (CSB++)|DIETARY_SUPPLEMENT: Sprinkles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: AZD2171 in Treating Patients With Refractory Metastatic Kidney Cancer
Status: TERMINATED
Conditions: Clear Cell Renal Cell Carcinoma|Recurrent Renal Cell Cancer|Stage IV Renal Cell Cancer
Interventions: DRUG: cediranib maleate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigation of AGS-009 in Patients With Systemic Lupus Erythematosus (SLE)
Status: COMPLETED
Conditions: Inflammation|Systemic Lupus Erythematosus (SLE)
Interventions: DRUG: AGS-009|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Antidepressant + SPD489 (Lisdexamfetamine dimesylate )|DRUG: Antidepressant + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intramuscular Effect of Polymerized Type I Collagen on the Cytokine Storm in COVID-19 Patients
Status: UNKNOWN
Conditions: Covid19|Cytokine Storm|Regulation of Inflammatory Response|Pulmonary Fibrosis
Interventions: DRUG: Collagen-Polyvinylpyrrolidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Healthy Normal Volunteers Looking at Exposure and Effects of Multiple Doses of Technosphere® Insulin (TI) Using the Gen2C Inhaler
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Technosphere Insulin Inhalation Powder using the Gen2C inhaler|DRUG: Regular Human Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Macronutrients on Hepatic Lipids, Plasma Triglycerides, and Insulin Sensitivity
Status: COMPLETED
Conditions: Metabolic Syndrome X|Liver Diseases
Interventions: OTHER: diet intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sulforadex in Healthy Volunteers SAD
Status: COMPLETED
Conditions: Stage, Prostate Cancer
Interventions: DRUG: Sulforadex|DRUG: Alpha cyclodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Phenylephrine Infusion for Preventing Hypotension During Spinal Anesthesia
Status: COMPLETED
Conditions: Orthopedic Surgery of Lower Limb
Interventions: DRUG: phenylephrine infusion|DRUG: patients receiving saline infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study to Evaluate the Pharmacokinetics, Safety and Tolerability of CKD-355
Status: COMPLETED
Conditions: Alzheimer's Disease (AD)
Interventions: DRUG: CKD-355A (D797/Memantine HCl 20mg)|DRUG: CKD-355B (D797/Memantine HCl 20mg)|DRUG: D797|DRUG: D324 (Memantine HCl 10mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ventilator Monitoring in Early Exacerbation Detection
Status: COMPLETED
Conditions: Respiratory Failure|Neuromuscular Disease|Chest Wall Disorder|Chronic Obstructive Pulmonary Disease|Obesity Hypoventilation Syndrome
Interventions: DEVICE: iVAPS ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Precarious Elderly Patient Supported For Cancer Impact on Quality Of Life of a Domotic And Remote Assistance Approach for Elderly Patients Supported For Locally Advanced or Metastatic Cancer, Socially Isolated
Status: UNKNOWN
Conditions: Elderly|Locally Advanced or Metastatic Cancer
Interventions: OTHER: Program of geriatric and Social intervention associated techniques of Domotic and Remote assistance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Veno-venous Extracorporeal Membrane Oxygenation (VV-ECMO) Heparin Study
Status: UNKNOWN
Conditions: ECMO|Heparin|Respiratory Failure
Interventions: DRUG: subcutaneous heparin anticoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: iCanCope With Post-Operative Pain (iCanCope PostOp)
Status: RECRUITING
Conditions: Pain, Chronic|Pain, Chronic Post-Surgical
Interventions: BEHAVIORAL: iCanCope Post Op Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of the Effects Suprascapular Nerve Block and Intra-articular Shoulder Injection
Status: COMPLETED
Conditions: Adhesive Capsulitis
Interventions: DRUG: 2 ml of 40 mg triamcinolone acetonide and 4 ml of 1% lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Purified Human Antibodies Administered Subcutaneously to Patients With Multifocal Motor Neuropathy (MMN)
Status: COMPLETED
Conditions: Multifocal Motor Neuropathy (MMN)
Interventions: BIOLOGICAL: Vivaglobin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation to Confirm Safety and Efficacy of Sinuplasty in the Paranasal Sinuses (CLEAR)
Status: COMPLETED
Conditions: Chronic Sinusitis
Interventions: DEVICE: Sinuplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled 14-week Study of DS-5565 in Chinese Patients With Diabetic Peripheral Neuropathic Pain
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathic Pain
Interventions: DRUG: Mirogabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 12-week Study of NFX-179 Gel in Subjects With Epidermal Nevi
Status: WITHDRAWN
Conditions: Epidermal Nevi|Nevus Sebaceus
Interventions: DRUG: NFX-179 Gel 1.50%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of a Treated, Devitalized and Sterile Umbilical Cord Amniotic Membrane in the Treatment of PIP Joint Osteoarthritis
Status: RECRUITING
Conditions: Osteoarthritis Hand
Interventions: BIOLOGICAL: SclerFIX-IP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cefoperazone/Sulbactam In The Treatment Of Serious Intra-Abdominal And Hepatobiliary Infections.
Status: WITHDRAWN
Conditions: Abscess, Intra-Abdominal|Cholecystitis|Wound Infections|Peritonitis|Appendicitis
Interventions: DRUG: CP-75385-02 Cefoperazone/sulbactam
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Massage and Foot Reflexology on Newborns' Sleep
Status: RECRUITING
Conditions: Preterm Infants|Sleep
Interventions: OTHER: Massage|OTHER: Foot Reflexology|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Re-evaluation of Blind Intubation Through the Air-Q Intubating Laryngeal Airway
Status: COMPLETED
Conditions: Techniques of Endotracheal Intubation in Pediatrics
Interventions: PROCEDURE: Blind tracheal intubation through AirQ|PROCEDURE: Fiberscopic tracheal intubation through AirQ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: CBD for Individuals at Risk for Alzheimer's Disease
Status: RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: DRUG: Cannabidiol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Toripalimab Combined With FLOT Neoadjuvant Chemotherapy in Patients With Resectable Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: Toripalimab|DRUG: Docetaxel|DRUG: Fluorouracil|DRUG: Leucovorin|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab + Ipilimumab + Radiation in MSS Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer|Metastatic Pancreatic Cancer
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Mobile-based HIV Prevention Intervention Involving Incentive Policy for Doctors in Liangshan, China
Status: NOT_YET_RECRUITING
Conditions: HIV/AIDS
Interventions: BEHAVIORAL: Mobile-based HIV-related educational message delivery|BEHAVIORAL: Incentive policies evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Antiseptic-coated Intermittent Urinary Catheter
Status: WITHDRAWN
Conditions: Neurogenic Bladder|Catheter-Related Infections
Interventions: DEVICE: Antiseptic-coated catheter|DEVICE: Hydrophilic catheter|DRUG: Octenidine chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Body Weight Support Treadmill Training on Lower Limb Function in Patients With Chronic Stroke
Status: COMPLETED
Conditions: Stroke|Gait Disorder, Sensorimotor
Interventions: OTHER: Body weight support treadmill training + conventional therapy|OTHER: Conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Simple Crossover Versus Side Branch Opening in Patients With Non-Left Main Bifurcation Lesion
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Simple Crossover|PROCEDURE: Side branch opening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Treat Uveitis Associated Macular Edema
Status: TERMINATED
Conditions: Cystoid Macular Edema|Uveitis
Interventions: DRUG: denufosol tetrasodium (INS37217) Intravitreal Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Mechanisms Underlying the Regulation of Impaired Glucose Tolerance by Auricular Concha Electro-acupuncture
Status: UNKNOWN
Conditions: Impaired Glucose Tolerance
Interventions: DEVICE: ta-VNS|OTHER: Electro-acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fischer Cone Biopsy Excisor Versus Loop Excision Procedure for Conization
Status: COMPLETED
Conditions: Uterine Cervical Dysplasia
Interventions: PROCEDURE: Fischer Cone Biopsy Excisor|PROCEDURE: Loop Excision Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Thoracic Epidural Analgesia and Surgery on Lower Urinary Tract Function: A Randomized, Controlled Study
Status: COMPLETED
Conditions: Analgesia, Epidural|Urodynamics|Urinary Retention
Interventions: DRUG: Bupivacain 0.125%|DRUG: Bupivacain 0.125%/Fentanyl 2mcg/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Efficacy of Tamsulosin Oral-controlled Absorption System (OCAS) in the Treatment of Distal Ureteral Stones
Status: UNKNOWN
Conditions: Ureteral Calculi
Interventions: DRUG: Tamsulosin Hydrochloride OCAS 0.4 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Virtual Reality in the Reduction of Pain After the Administration of Vaccines Among Children in Primary Care Centers.
Status: COMPLETED
Conditions: Pain|Pediatrics|Vaccination|Virtual Reality
Interventions: DEVICE: Pico G2 Virtual Reality Glasses (Pico Interactive Inc), together with an Android AOYODKG tablet|BEHAVIORAL: Traditional Distractors|BIOLOGICAL: Triple Viral + Varicella Vaccine at 3 years of age|BIOLOGICAL: Hepatitis A + Diphtheria-Tetanus-Pertussis Vaccine at 6 years of age.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Balloon Assisted Maceration Versus Rotational Thrombectomy in Dialysis Access Salvage
Status: WITHDRAWN
Conditions: Dialysis Access Malfunction|Dialysis; Complications
Interventions: DEVICE: Cleaner XT|DEVICE: Balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of the Treatment of Acute Ischemic Stroke Using the NOVIS Transcarotid Neuroprotection System
Status: UNKNOWN
Conditions: Acute Ischemic Stroke
Interventions: DEVICE: NOVIS Transcarotid Neuroprotection System (NPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab With Radiation Therapy and Bevacizumab for Recurrent MGMT Methylated Glioblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma
Interventions: RADIATION: Re-irradiation (RT)|DRUG: Bevacizumab|DRUG: Nivolumab|PROCEDURE: Re-resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assess the Efficacy of the Low Glucose Suspend (LGS) Feature in the MiniMed Paradigm® X54 System
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: The MiniMed Paradigm® X54 System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nintedanib+Letrozole in Postmenopausal Women With Breast Cancer: Clinical Trial Safety and Pharmacodynamics
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Nintedanib|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Therapy to Sustain the Antidepressant Effects of Intravenous Ketamine in Treatment-resistant Depression
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: OTHER: Cognitive behavioral therapy (CBT) and medication|OTHER: Psychoeducation and medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety of Epoetin Alfa and Its Effectiveness in Facilitating the Presurgical Collection of Blood From Anemic Patients for Possible Self-transfusion During and After Scheduled Joint Surgery.
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Therapeutic Effect of Low-intensity Focused Ultrasound on Painful Diabetic Peripheral Neuropathy
Status: RECRUITING
Conditions: Painful Diabetic Neuropathy
Interventions: DEVICE: Low-Intensity Focused Ultrasound (LIFU)|DEVICE: Sham Low-Intensity Focused Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Use of Anesthetic Block for the Prevention of in Hospital Delirium in Patients of the Orthogeriatric Clinical Care Center of the HUFSFB and HUSJI From 2019 - 2020
Status: UNKNOWN
Conditions: Delirium in Old Age|Fragility Fracture|Hip Fractures
Interventions: PROCEDURE: Anesthetic nerve block
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Denosumab in Combination With Enzalutamide in Progressive Metastatic Castrate-resistant Prostate Cancer and Bone Metastases.
Status: TERMINATED
Conditions: Castration-resistant Prostate Cancer|Metastatic Cancer|Bone Metastases
Interventions: DRUG: Xgeva|DRUG: Xtandi
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Injection Under US Control in GTPS.
Status: TERMINATED
Conditions: Periarthritis|Bursitis
Interventions: DRUG: rapidocain and bethametsaone|DRUG: sterile saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: THINC-it Vortioxetine - Sensitivity to Change
Status: COMPLETED
Conditions: Major Depressive Disorder|Cognitive Change
Interventions: DRUG: Vortioxetine|OTHER: THINC-it Tool
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Preoperative Warming and Perioperative Shivering
Status: UNKNOWN
Conditions: Forced Air Warming Effect on Hypothermia
Interventions: DEVICE: Forced Air Warmer|OTHER: No pre-op warming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Liposomal Doxorubicin Plus Combination Chemotherapy in Treating Patients With AIDS-Associated Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: sargramostim|DRUG: methotrexate|DRUG: pegylated liposomal doxorubicin hydrochloride|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Stereotactic HYpofractionateD RadioAblative (HYDRA) Treatment of Laryngeal Cancer
Status: RECRUITING
Conditions: Malignant Neoplasms of Respiratory and Intrathoracic Organs|Squamous Cell Carcinoma of the Larynx
Interventions: RADIATION: Stereotactic Hypofractionated Radioablation|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medium Calorie Parenteral Nutrition on Patients With Gastrointestinal Cancer Undergoing Surgery
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: DIETARY_SUPPLEMENT: Total Parenteral Nutrition (TPN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Comparison of Exergaming and Vestibular Training on Gaze Stability, Balance and Gait Performance of Older Adults.
Status: COMPLETED
Conditions: Older Adults
Interventions: OTHER: exergaming training|OTHER: training - Group II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effectiveness of Targeted Cognitive Training for Neurological Deficits in People With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Targeted cognitive training (TCT)|BEHAVIORAL: Computer games
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Bioequivalence of Bimekizumab Given as 1x2mL or 2x1mL Subcutaneous Injection in Healthy Study Participants
Status: TERMINATED
Conditions: Healthy Study Participants
Interventions: DRUG: Bimekizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Status: NOT_YET_RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction (HFpEF)
Interventions: DRUG: STM01
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coconut Oil vs. Commercial Ultrasound Gel In Obstetric Ultrasounds
Status: COMPLETED
Conditions: Pregnancy, High Risk
Interventions: DEVICE: Coconut Oil|DEVICE: Commercial Ultrasound Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: A Study of Ipatasertib Plus Palbociclib and Fulvestrant Versus Placebo Plus Palbociclib and Fulvestrant in Hormone Receptor Positive and HER2 Negative Locally Advanced Unresectable or Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Ipatasertib|DRUG: Placebo|DRUG: Palbociclib|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Antibacterial Effect and Substantivity of a New Chlorhexidine and Cymenol Gel on Oral Biofilm and Saliva
Status: COMPLETED
Conditions: Healthy|Saliva|Biofilms
Interventions: DRUG: 0.20% CHX gel on saliva|DRUG: 0.20% CHX and Cymenol gel on saliva|DRUG: 0.20% CHX gel on oral biofilm|DRUG: 0.20% CHX and Cymenol gel on oral biofilm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacodynamic Study to Compare Acute Effects of Dihydroergotamine Mesylate (DHE) on Pulmonary Arterial Pressure
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: MAP0004|DRUG: IV Placebo (Saline)|DRUG: Placebo Inhaler|DRUG: IV Dihydroergotamine Mesylate (DHE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cross-Over Evaluation of Two Lubricating Eye Drops
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Polyethylene Glycol 400 0.4%|DRUG: Propylene Glycol 0.3%|DRUG: 0.15% sodium Hyaluronate|DRUG: sodium chloride|DRUG: sodium phosphate monobasic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose:
Clinical trial: Effect of Ticagrelor and Clopidogrel on Coronary Microcirculation in Patients With Acute Myocardial Infarction
Status: COMPLETED
Conditions: Coronary Microvascular Disease|Ticagrelor|Thrombolysis|Microbubble Contrasted Echocardiography
Interventions: DIAGNOSTIC_TEST: Microbubble Contrasted Echocardiography|DIAGNOSTIC_TEST: Platelet Aggregability|DIAGNOSTIC_TEST: Laboratory
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Early On-treatment Transcriptional Profiling as Predictor of Response in Early-stage HER2-positive Breast Cancer
Status: RECRUITING
Conditions: HER2-positive Breast Cancer|Neoplasms|Breast Cancer
Interventions: DRUG: Trastuzumab (neoadjuvant)|DRUG: Pertuzumab (neoadjuvant)|DRUG: Paclitaxel (neoadjuvant)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Atezolizumab|DRUG: Trastuzumab Emtansine|DRUG: Placebo|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intervention for IPV-exposed Pregnant Women
Status: RECRUITING
Conditions: Postpartum Depression|Posttraumatic Stress Disorder|Infant Behavior|Violence|Parenting
Interventions: BEHAVIORAL: Pregnant Moms' Empowerment Program|BEHAVIORAL: Nondirective Support Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study With Repeated Doses of Stalevo
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: levodopa, carbidopa, entacapone|DRUG: levodopa, carbidopa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of ESWT on ED in Type 2 Diabetics
Status: UNKNOWN
Conditions: Erectile Dysfunction|Diabetes Mellitus, Type 2
Interventions: DEVICE: active extracorporeal shock wave|DEVICE: sham extracorporeal shock wave
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Low Fluoride Dentifrice for Caries Control
Status: COMPLETED
Conditions: Dental Caries
Interventions: OTHER: Low-fluoride acidic dentifrice|OTHER: conventional dentifrice|OTHER: neutral pH and low-fluoride dentifrice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Aliskiren and the Calcium Channel Blocker Amlodipine Combination as an Initial Treatment Strategy for Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Amlodipine|DRUG: hydrochlorothiazide|DRUG: Aliskiren
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Combining Cocoa and Soy in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes|Dietary Intervention
Interventions: DIETARY_SUPPLEMENT: Soy protein|DIETARY_SUPPLEMENT: Isoflavones|DIETARY_SUPPLEMENT: Cocoa|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Genetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Glioblastoma|Recurrent Malignant Glioma|Recurrent WHO Grade II Glioma|Recurrent WHO Grade III Glioma|Refractory Glioblastoma|Refractory Malignant Glioma|Refractory WHO Grade II Glioma|Refractory WHO Grade III Glioma
Interventions: BIOLOGICAL: IL13Ralpha2-specific Hinge-optimized 4-1BB-co-stimulatory CAR/Truncated CD19-expressing Autologous TN/MEM Cells|BIOLOGICAL: IL13Ralpha2-specific Hinge-optimized 41BB-co-stimulatory CAR Truncated CD19-expressing Autologous T-Lymphocytes|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Magnetic Resonance Spectroscopic Imaging|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Triple Combination Therapy in High Risk Crohn's Disease (CD)
Status: COMPLETED
Conditions: Crohn Disease
Interventions: DRUG: Vedolizumab|DRUG: Adalimumab|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BMS-512148 (Dapagliflozin) in Patients With Type 2 Diabetes With Inadequately Controlled Hypertension on an ACEI or ARB and an Additional Antihypertensive Medication
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Dapagliflozin|DRUG: Placebo matching Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aloe Vera Ointment Application and Skeletal Muscle Recovery
Status: COMPLETED
Conditions: Skeletal Muscle Damage|Exercise-induced Aseptic Inflammation|Performance
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: Natural Aloe Vera|BIOLOGICAL: Aloe vera soup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Assess Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With Acromegaly
Status: COMPLETED
Conditions: Acromegaly
Interventions: DRUG: CAM2029 (octreotide subcutaneous depot)|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: sPIF CLINICAL STUDY PROTOCOL IN AUTOIMMUNE HEPATITIS
Status: COMPLETED
Conditions: Autoimmune Hepatitis
Interventions: DRUG: sPIF|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide in Combination With Microtransplantation as Post-remission Therapy in AML
Status: TERMINATED
Conditions: Acute Myeloid Leukemia (AML)|Acute Myelocytic Leukemia|Acute Myelogenous Leukemia|Acute Granulocytic Leukemia|Acute Non-Lymphocytic Leukemia
Interventions: DRUG: Lenalidomide|GENETIC: HLA-mismatched stem-cell Microtransplantation|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Algorithm to Control Postprandial, Post Exercise and Night Glucose Excursions in a Portable Closed Loop Format,
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DEVICE: Insulin pump therapy (with or without glucose sensor)|DEVICE: Artificial pancreas (Inreda Diabetic)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-Dose, Three-Way, Three-Sequence, Crossover BA Study of Azithromycin Oleogel
Status: NOT_YET_RECRUITING
Conditions: Infectious Disease|Drug Effect|Clinical Infection
Interventions: DRUG: Azithromycin Oleogel (Oral and Rectal)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Prospective Phase II Randomized Clinical Trial of Preoperative Chemotherapy Combined With Short-course Radiotherapy Versus Conventional Neo-adjuvant Therapy for Locally Advanced Rectal Cancer Implemented by MDT
Status: UNKNOWN
Conditions: Rectal Cancer, Radiotherapy
Interventions: RADIATION: Short-course radiotherapy|DRUG: FOLFOX4 chemotherapy,preoperative|RADIATION: Radiotherapy of neo-adjuvant therapy|DRUG: Concurrent chemotherapy of neo-adjuvant therapy|PROCEDURE: Radical rectal cancer resection|DRUG: FOLFOX4 chemotherapy,post-operative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promitil Treatment of Patients With Solid Tumors Associated With Deleterious Mutations Who Have Progressed After Therapy
Status: RECRUITING
Conditions: Cancer of Ovary|Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: Promitil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non Substitutive Strategies to Improve Haemophilia Care in Developing Countries. Experience in Ivory Coast.
Status: COMPLETED
Conditions: Haemophilia|Developing Countries
Interventions: OTHER: Education|DIAGNOSTIC_TEST: Improve biological diagnosis and follow-up of haemophilia|DRUG: Implement haemostatic non substitutive care of haemophilia|OTHER: Implement non haemostatic care of haemophilia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dose Escalation Trial of Bexmarilimab (FP-1305) Plus Pembrolizumab in Non-Small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: bexmarilimab (FP-1305)|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relapse Prevention With Escitalopram or Nortriptyline Following Electro-Convulsive Treatment (DUAG-7)
Status: TERMINATED
Conditions: Major Depression
Interventions: DRUG: escitalopram|DRUG: escitalopram|DRUG: escitalopram|DRUG: nortriptyline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Two Newly Developed 1-piece Convex Baseplates in Subjects With Ileostomy and Colostomy
Status: COMPLETED
Conditions: Ileostomy - Stoma|Colostomy - Stoma
Interventions: DEVICE: Coloplast Test V|DEVICE: Coloplast Test X
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pembrolizumab (MK-3475) Plus Gemcitabine/Cisplatin Versus Placebo Plus Gemcitabine/Cisplatin for First-Line Advanced and/or Unresectable Biliary Tract Carcinoma (BTC) (MK-3475-966/KEYNOTE-966)-China Extension Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Biliary Tract Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Yoga and Wellness Program for Breast Cancer Survivors With Persistent Fatigue
Status: COMPLETED
Conditions: Breast Cancer|Fatigue
Interventions: OTHER: Iyengar Yoga|OTHER: Wellness Seminar Series
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Predictors of Response to Manual Physiotherapy Using Somatosensory Profiles in Patients With Cervicobrachial Pain
Status: RECRUITING
Conditions: Cervical Radicular Pain|Cervical Radiculopathy|Cervical Pain
Interventions: OTHER: Manual physiotherapy and neurodynamic exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Whole Body Vibrationin in Patients With Non-Specific Low Back Pain
Status: RECRUITING
Conditions: Low Back Pain|Low Back Pain, Mechanical|Low Back Pain, Postural|Low Back Pain, Recurrent
Interventions: DEVICE: Whole body vibration|BEHAVIORAL: lumbar stabilization exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Hemodynamic Effects of Cocoa Polyphenols in Subjects With Hypertension and Optimal Blood Pressure
Status: COMPLETED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: cocoa polyphenols|DIETARY_SUPPLEMENT: cocoa polyphenols
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Compassionate Use of CAR T Cells Targeting the CD19 Antigen and Containing the Inducible Caspase 9 Safety Switch
Status: NO_LONGER_AVAILABLE
Conditions: Acute Lymphoblastic Leukemia|Immune System Diseases|Immunoproliferative Disorders
Interventions: DRUG: iC9-CAR19 cells|DRUG: AP1903|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: EXPANDED_ACCESS
Clinical trial: A Phase I Study of Candidate Influenza Vaccines MVA-NP+M1 and ChAdOx1 NP+M1
Status: COMPLETED
Conditions: Seasonal Influenza
Interventions: BIOLOGICAL: MVA NP+M1|BIOLOGICAL: ChAdOx1 NP+M1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Role of Laparoscopy in Penetrating Anterior Abdominal Wall Injuries
Status: RECRUITING
Conditions: Evaluate Laparoscopic Management in Patients With Penetrating Anterior Abdominal Wall Trauma
Interventions: PROCEDURE: diagnostic laparoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Asparaginase|DRUG: Asparaginase Erwinia chrysanthemi|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|BEHAVIORAL: Cogstate Assessment Battery|PROCEDURE: Computed Tomography|DRUG: Cytarabine|DRUG: Daunorubicin Hydrochloride|DRUG: Dexrazoxane Hydrochloride|DRUG: Etoposide|OTHER: Fludeoxyglucose F-18|DRUG: Gemtuzumab Ozogamicin|DRUG: Gilteritinib Fumarate|DRUG: Liposome-encapsulated Daunorubicin-Cytarabine|PROCEDURE: Magnetic Resonance Imaging|DRUG: Methotrexate|DRUG: Mitoxantrone Hydrochloride|PROCEDURE: Positron Emission Tomography|DRUG: Therapeutic Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunosuppression in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: CNI, MMF, Steroids, Aza etc. (mTOR inhibitor free)|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir With or Without Sofosbuvir and Ribavirin in Direct-Acting Antiviral Agent Treatment-Experienced Adults With Chronic Hepatitis C Virus Infection
Status: COMPLETED
Conditions: Chronic Hepatitis C Infection
Interventions: DRUG: ombitasvir/paritaprevir/ritonavir and dasabuvir|DRUG: Sofosbuvir|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Efficacy and Safety of Saxagliptin in Combination With Metformin in Adult Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Saxagliptin|DRUG: Placebo|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of An Innovative Smartphone Intervention for Smoking Cessation
Status: COMPLETED
Conditions: Smoking
Interventions: BEHAVIORAL: Smartphone-delivered Intervention (SmartQuit)|BEHAVIORAL: : Smartphone-delivered Intervention (Standard of care app)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of APP13007 for Treatment of Inflammation and Pain After Cataract Surgery Including a Corneal Endothelial Cell Sub-study
Status: COMPLETED
Conditions: Ocular Inflammation and Pain After Cataract Surgery
Interventions: DRUG: APP13007, 0.05%|DRUG: Matching Vehicle Placebo for APP13007, 0.05%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The eXtroardinarY Babies Study: Natural History of Health and Neurodevelopment in Infants and Young Children With Sex Chromosome Trisomy
Status: RECRUITING
Conditions: Klinefelter Syndrome|Trisomy X|XYY Syndrome|XXXY and XXXXY Syndrome|Xxyy Syndrome|Xyyy Syndrome|Xxxx Syndrome|Xxxxx Syndrome|Xxxyy Syndrome|Xxyyy Syndrome|Xyyyy Syndrome|Male With Sex Chromosome Mosaicism
Interventions: OTHER: Assessments of Development and Growth
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Toothpaste Containing the Active Ingredient of Galla Chinensis Extract on Treating Dentin Hypersensitivity
Status: COMPLETED
Conditions: Tooth Sensitivity
Interventions: OTHER: galla chinensis|OTHER: Stannous fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Direct Transfer to an Endovascular Center Compared to Transfer to the Closest Stroke Center in Acute Stroke Patients With Suspected Large Vessel Occlusion
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Direct transfer to an Endovascular Center
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Evaluate the Safety, Tolerability and Efficacy of Tocilizumab in Participants With Rheumatoid Arthritis (RA) Who Have an Inadequate Response to Non-Biologic Disease Modifying Anti-rheumatic Drugs (DMARDs) and/or Anti-tumor Necrosis Factor (Anti-TNF) Therapy
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tocilizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison Trial of Open-tip Pulsed Needle Biopsy and Conventional Core Biopsy in Axillary Lymph Nodes
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DEVICE: Open-tip pulsed needle biopsy (NeoNavia Biopsy System)|DEVICE: Core needle biopsy (CNB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of Intrathecal Dexmedetomidine on Spinal Anesthesia Using Diluted Low-Dose Bupivacaine for Transurethral Resection of Prostate in Elderly
Status: COMPLETED
Conditions: Benign Prostatic Hypertrophy
Interventions: DRUG: spinal anesthesia|DRUG: spinal anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Acute and Sub-acute Administration of Gluten on Extra-intestinal and Gastrointestinal Symptoms in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers, Gluten
Interventions: OTHER: Gluten|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Choroidal Blood Flow Regulation During Isometric Exercise: Effects of Ca2+-Channel Blockade
Status: COMPLETED
Conditions: Ocular Physiology|Regional Blood Flow
Interventions: DRUG: Nifedipine (drug)|DRUG: L-Arginin (drug)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Quinapril 40 mg With Alpha Lipoic Acid or Placebo on Diabetes and Hypertension
Status: COMPLETED
Conditions: Diabetes|Hypertension
Interventions: DRUG: Quinapril (Accupril) plus Alpha Lipoic Acid|DRUG: accupril, placebo|DRUG: accupril, alpha lipoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Daptomycin Safety and Efficacy for Complicated Skin and Skin Structure Infections (cSSSI) and Bacteremia in Renal Impairment
Status: TERMINATED
Conditions: Complicated Skin and Skin Structure Infections|S. Aureus Bacteremia|Renal Impairment
Interventions: DRUG: Vancomycin|DRUG: Daptomycin|DRUG: Semi-Synthetic Penicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pomalidomide, Ixazomib Citrate, and Dexamethasone in Treating Patients With Previously Treated Multiple Myeloma or Plasma Cell Leukemia
Status: COMPLETED
Conditions: Plasma Cell Leukemia|Plasma Cell Myeloma|Plasmacytoma
Interventions: DRUG: Dexamethasone|DRUG: Ixazomib Citrate|OTHER: Laboratory Biomarker Analysis|DRUG: Pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Candida Albicans Growth on BreFlex Versus PEEK Denture Base in Maxillary Bounded Partial Denture
Status: UNKNOWN
Conditions: Candida Albicans Infection
Interventions: OTHER: PEEK|OTHER: Bre-Flex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Alberta Lung Cancer Screening Program
Status: UNKNOWN
Conditions: Lung Neoplasms|Respiratory Tract Neoplasms
Interventions: PROCEDURE: Computed Tomography|BEHAVIORAL: Active smokers - Smoking cessation arm|BEHAVIORAL: Active smokers - Control arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING