pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream With Phototherapy in Participants With Vitiligo
Status: COMPLETED
Conditions: Vitiligo
Interventions: DRUG: Ruxolitinib 1.5% cream|DEVICE: NB-UVB phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Actigraphy and Nocturnal Heartrate Variability in Cluster Headache Patients
Status: COMPLETED
Conditions: Cluster Headache|Sleep
Interventions: DEVICE: Actigraphy|DEVICE: Heart-rate variability monitoring|DEVICE: Pupillometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: IAI Versus Sham as Prophylaxis Against Conversion to Neovascular AMD
Status: UNKNOWN
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: Intravitreal aflibercept injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Intravenous Dexamethasone on Duration of Hyperbaric Bupivacaine Spinal Anesthesia in Lower Abdominal Surgery
Status: COMPLETED
Conditions: Spinal Anesthesia
Interventions: DRUG: Placebo|DRUG: i.v dexmethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison of Two Different Lipid Emulsions for Parenteral Nutrition in Preterm Infants
Status: COMPLETED
Conditions: Preterm Infants|Parenteral Nutrition n-3 Fatty Acids
Interventions: DRUG: Lipofundin MCT/LCT 20 %|DRUG: Lipidem 20%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Multi-center, Double-blind, Randomized Study, Comparing Clindamycin Phosphate Vaginal Cream 2% (Watson Laboratories, Inc.) to Clindesse® (Ther-Rx™, Clindamyin Phosphate Vaginal Cream 2%) and Both Active Treatments to a Placebo Control in the Treatment of Bacterial Vaginosis in Non-pregnant Women
Status: COMPLETED
Conditions: BACTERIAL VAGINOSIS|Signs and Symptoms to be Evaluated and Recorded Include|Vaginal Discharge Color, Odor, and Consistency|Vulvovaginal Itching and Irritation (Subjective) Absent, Mild, Moderate, or Severe|Vulvovaginal Inflammation (Objective) Absent, Mild, Moderate, or Severe
Interventions: DRUG: clindamycin phosphate vaginal cream 2%|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Accelerated Intermittent Theta Burst Stimulation for Depressed Patients During the Covid-19 Pandemic
Status: COMPLETED
Conditions: Treatment Resistant Depression
Interventions: DEVICE: Intermittent Theta Burst Stimulation (form of repetitive transcranial magnetic stimulation) given in an accelerated form
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Whole Body HER3 Quantification With Radiolabelled Patritumab Deruxtecan (HER3-DXd) PET/CT
Status: NOT_YET_RECRUITING
Conditions: Non-Small Cell Lung Carcinoma|Advanced Non-Small Cell Squamous Lung Cancer|EGFR Gene Mutation
Interventions: DRUG: 89Zr-Patritumab deruxtecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of High Dose Insulin on Infectious Complications Following Major Surgery
Status: RECRUITING
Conditions: Surgical Site Infection After Major Surgery
Interventions: OTHER: Hyperinsulinemic normoglycemic clamp|OTHER: Standard glucose management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment Plan CINC280A02001M to Provide Access to Capmatinib, for MET Exon 14 Skipping Non-Small Cell Lung Cancer (NSCLC)
Status: AVAILABLE
Conditions: Carcinoma, Non-Small Cell Lung|Non-Small Cell Lung Cancer|Non-Small-Cell Lung Carcinoma|Nonsmall Cell Lung Cancer
Interventions: DRUG: Capmatinib
Study Type: EXPANDED_ACCESS
Clinical trial: The Effects of Ibandronate or Teriparatide Therapy on Bone Histology and Biochemical Indices in Patients on Hemodialysis With Low Bone Mineral Density
Status: TERMINATED
Conditions: Osteoporosis
Interventions: DRUG: ibandronate|DRUG: teriparatide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects on PaCO2 Levels of Two Different Nasal Cannula in COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: AIRVO 2, with conventional symmetric nasal cannula|DEVICE: AIRVO 2, the new asymmetric nasal cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab-containing Regimen for Metastatic Colorectal Cancer Failed to Cytotoxic Treatment
Status: UNKNOWN
Conditions: Neoplasm|Colorectal Cancer|Metastatic Neoplasm
Interventions: DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intubation in Morbidly Obese: a Comparison of Airtraq and ILMA
Status: COMPLETED
Conditions: Intubation; Difficult or Failed|Intubation Complication
Interventions: DEVICE: Airtraq|DEVICE: ILMA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Oliceridine-Enhanced Analgesia and Recovery: A G-Protein Biased μ-Opioid Study
Status: NOT_YET_RECRUITING
Conditions: Postoperative Analgesia
Interventions: DRUG: Oliceridine fumarate low dose|DRUG: Oliceridine fumarate high dose|DRUG: Oliceridine fumarate moderate dose|DRUG: morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Monocytic Expression of Heme Oxidase-1 (HO-1) in Sickle Cell Patients and Correlation With the Humoral Immune Response to Vaccine and With Allo-immunization.
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: BIOLOGICAL: Inactivated influenza A (H1N1) virus vaccine|DIAGNOSTIC_TEST: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Back2LiveWell: Community Based Prevention of Back Pain Flare-ups
Status: COMPLETED
Conditions: Low Back Pain, Recurrent|Low Back Pain
Interventions: OTHER: Physical activity program|OTHER: Control group standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oxytocin in Alcohol Use Disorder
Status: WITHDRAWN
Conditions: Alcoholism
Interventions: DRUG: Oxytocin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Medial Plica Syndrome of the Knee: Conservative Treatment Versus Arthroscopic Plica Resection - a Randomized Controlled Multicenter Trial
Status: UNKNOWN
Conditions: Plica Mediopatellaris
Interventions: PROCEDURE: Plica resection vs conservative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid Sparing Analgesia: Dexmedetomidine Versus Lidocaine for Intracranial Surgeries in Children
Status: COMPLETED
Conditions: Analgesia
Interventions: DRUG: Dexmedetomidine injection|DRUG: Lidocaine Iv
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ramipril and Hydrochlorothiazide Alone and in Combination for the Treatment of Essential Hypertension
Status: COMPLETED
Conditions: Hypertension|Blood Pressure, High
Interventions: DRUG: Ramipril and hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Intrabone Transplantation of Allogenic Peripheral Blood Stem Cells in Patients With Myeloid and Lymphoid Malignancies.
Status: UNKNOWN
Conditions: Leukemia|Lymphoma
Interventions: PROCEDURE: Intrabone transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AZD2171 and Combination Chemotherapy in Treating Women With Locally Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: pegfilgrastim|DRUG: cediranib maleate|DRUG: cyclophosphamide|DRUG: docetaxel|DRUG: doxorubicin hydrochloride|OTHER: laboratory biomarker analysis|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Zoledronic Acid Treatment on Bone-related Events in Breast Cancer Patients With Bone Metastases: a Prospective, Multicenter, Real-world Study
Status: NOT_YET_RECRUITING
Conditions: Histologically Confirmed Breast Cancer ,Diagnosis of Bone Metastasis
Interventions: OTHER: Non-intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of PET Adapted Therapy and Non-invasive Monitoring for Previously Untreated Limited Stage Diffuse Large B Cell Lymphoma
Status: RECRUITING
Conditions: DLBCL
Interventions: DRUG: Rituximab Prednisone|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MicroVention, Inc. Flow Re-Direction Endoluminal Device X (FRED™ X™) Post-Approval Study
Status: RECRUITING
Conditions: Intracranial Aneurysm
Interventions: DEVICE: FRED™ X™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRO1107 in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Endometrial Cancer|Ovarian Cancer|Triple Negative Breast Cancer|GastroEsophageal Cancer|Non-small Cell Lung Cancer|Urothelial Carcinoma
Interventions: DRUG: PRO1107
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of the Thoracoabdominal and Pararenal Aortic Aneurysms (TAMBE)
Status: AVAILABLE
Conditions: Thoracoabdominal Aneurysm
Interventions: DEVICE: GORE Excluder Thoracoabdominal Branch Endoprosthesis
Study Type: EXPANDED_ACCESS
Clinical trial: Comparison of Tumor Efficacy Safety in Laparoscopic Resection of Gastrointestinal Stromal Tumors Between Favorable and Unfavorable Site
Status: RECRUITING
Conditions: GIST of Stomach|Gastric Cancer|Surgery|Complication
Interventions: PROCEDURE: Laparoscopic resection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Investigation of AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric Intraocular Lens (IOL)
Status: COMPLETED
Conditions: Cataracts
Interventions: DEVICE: AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric IOL|DEVICE: AcrySof® ReSTOR® Multifocal IOL Model SA60D3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualized Timing of Analgesia and Effectiveness of Labor Analgesia
Status: COMPLETED
Conditions: Labor Pain|Analgesia, Obstetrical|Early Medical Intervention
Interventions: DRUG: Individualized epidural analgesia|DRUG: Routine epidural analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prevention of Oral Malodor With an Oral Sticker Containing Herbal Formula
Status: COMPLETED
Conditions: Halitosis|Oral Malodor|Bad Breath
Interventions: DEVICE: a mucosal sticker with herbal formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: The Articulated Oral Airway as an Aid to Mask Ventilation
Status: COMPLETED
Conditions: Mask Ventilation|Airway Obstruction Upper|Airway Management
Interventions: DEVICE: Articulated Oral Airway|DEVICE: Guedel oral airway (active comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antibiotics Versus Placebo in the Treatment of Abscesses in the Emergency Department
Status: TERMINATED
Conditions: Abscess
Interventions: DRUG: Trimethoprim-sulfamethoxazole|DRUG: Sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Spine Posture, Trunk Position Sense and Gait in Axial Spondyloarthritis Patients
Status: UNKNOWN
Conditions: Non-radiographic Axial Spondyloarthritis|Ankylosing Spondylitis
Interventions: DIAGNOSTIC_TEST: Gait parameters|DIAGNOSTIC_TEST: Spine posture|DIAGNOSTIC_TEST: Trunk position sense
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Complementary Contributions of Sensory Stimulation and Social Support During Snoezelen Room Therapy on the General Physical and Emotional Health of the Elderly Population: Optimization of the Nursing Home Resources.
Status: UNKNOWN
Conditions: Loneliness|Aging
Interventions: OTHER: sensory stimulating therapy|OTHER: social support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PGT-A Evaluates Advanced Sperm Selection in Embryos From High Teratozoospermia Males
Status: COMPLETED
Conditions: Teratozoospermia|Sperm DNA Fragmentation|Infertility
Interventions: DEVICE: Sperm Selection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Managing DIabetes Remission After Combined Therapy in EarLy Stage of DiabetEs
Status: ACTIVE_NOT_RECRUITING
Conditions: Newly Diagnosed Type 2 Diabetes
Interventions: DRUG: Metformin-Sitagliptin-Empaglifozin-Pioglitazone|DRUG: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Establishment and Assessment of the HVPG Using Biofluid Mechanics (HVPGBFM)
Status: UNKNOWN
Conditions: Liver Cirrhosis|Hypertension, Portal
Interventions: PROCEDURE: HVPG measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Vimecon CAI Trial for the Interventional Treatment of Paroxysmal Atrial Fibrillation (AF)
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Vimecon Laser CAI percutaneous cardiac ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fat Metabolites and Gut Hormones
Status: UNKNOWN
Conditions: Overweight and Obesity|Type 2 Diabetes|Bariatric Surgery|Gut Hormones|Dietary Fat
Interventions: DIETARY_SUPPLEMENT: C-8 dietary oil|DIETARY_SUPPLEMENT: Tricaprylin|DIETARY_SUPPLEMENT: Olive oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Pain in Head-and-Neck Cancer Patients: is Methadone More Effective?
Status: COMPLETED
Conditions: Pain|Cancer of Head and Neck
Interventions: DRUG: fentanyl|DRUG: methadone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Antimicrobial Efficacy of Green Tea, Garlic With Lime, Pomegranate Extract and Chlorhexidine Mouth Rinses in a Group of Egyptian Children (In-Vivo Study)
Status: COMPLETED
Conditions: Dental Caries
Interventions: PROCEDURE: Green tea extract mouth rinse|PROCEDURE: Garlic with lime extract mouth rinse|PROCEDURE: Pomegranate extract mouth rinse|PROCEDURE: Chlorhexidine mouth rinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Quantitative Ultrasound Response of Capsaicin
Status: COMPLETED
Conditions: Central Sensitisation
Interventions: DRUG: Capsaicin|DEVICE: Delsys Trigno Galileo System|DEVICE: Cadwell Sierra Wave|DEVICE: Sonosite Ultrasound Machine|DEVICE: Goniometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sonothrombolysis in Patients With STEMI
Status: COMPLETED
Conditions: ST-segment Elevation Myocardial Infarction
Interventions: DRUG: Definity, (Lipid Microspheres) Intravenous Suspension|DEVICE: Myocardial Contrast Echocardiography|PROCEDURE: Repurfusion therapy with PPCI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of Myofascial Arm Pull and Post Isometric Relaxation Techniques in Adhesive Capsulitis
Status: COMPLETED
Conditions: Adhesive Capsulitis
Interventions: OTHER: Myofascial arm pull technique|OTHER: post isometric relaxation technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept Study on Pitolisant Effect on Autism Spectrum Disorders in Children and Adolescents
Status: NOT_YET_RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Pitolisant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect on Optic Nerve Sheath Diameter in Patients Undergoing Cesarean Section
Status: UNKNOWN
Conditions: Intracranial Pressure
Interventions: PROCEDURE: USG guided ONSD measurement preepidural
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: App Delivered Brief Mindfulness Intervention for Surgical Patients
Status: RECRUITING
Conditions: Pain|Anxiety State|Depressive State
Interventions: BEHAVIORAL: Breath Counting|BEHAVIORAL: Body Scan|BEHAVIORAL: Mindful Breathing|BEHAVIORAL: Mindfulness of Pain|BEHAVIORAL: Mindful Savoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: C.O.R.P.U.S.: Observational Cohort of Adult and Child Inflammatory Arthritis in France
Status: COMPLETED
Conditions: Arthritis, Rheumatoid|Spondylitis, Ankylosing|Arthritis, Psoriatic|Arthitis, Juvenile Idiopathic
Interventions: DRUG: TNF-alpha antagonist and other biotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Smartphone APPlication for the Transmission of ECGs in the Management of Patients Presenting With Suspected Heart Attacks in the Hamilton, Niagara, Haldimand, and Brant Area
Status: COMPLETED
Conditions: Myocardial Infarction|STEMI
Interventions: OTHER: SMART AMI APPLICATION
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Calcium Absorption and Retention From Marine Products
Status: COMPLETED
Conditions: Calcium Metabolism
Interventions: BEHAVIORAL: Calcium controlled diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Internet-based Behaviour Therapy for Tourette's Disorder and Chronic Tic Disorder
Status: COMPLETED
Conditions: Tourette's Disorder|Persistent (Chronic) Motor or Vocal Tic Disorder
Interventions: BEHAVIORAL: Internet-delivered habit reversal training|BEHAVIORAL: Internet-delivered exposure and response prevention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fractional Flow Reserve Versus Angiography for Treatment-Decision and Evaluation of Significant Left MAIN Coronary Artery Disease
Status: RECRUITING
Conditions: Coronary Artery Disease Left Main|Coronary Artery Disease
Interventions: PROCEDURE: FFR-Guided PCI|PROCEDURE: Angiography-Guided PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Onco-coaching of Sport-inspired for the Social, Professional and Psychological Restoring of the Patients in Cancer Remission After Allogeneic Transplantation of Hematopoietic Stem Cells
Status: UNKNOWN
Conditions: Haematologic Disease (Cancer)|Onco-coaching of Sport- Inspirated
Interventions: OTHER: Interviews with coach
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Biomarker-Driven Therapy in Metastatic Colorectal Cancer (mCRC)
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Cetuximab|DRUG: FOLFOX induction regimen|DRUG: Fluoropyrimidine (5-FU/LV or capecitabine)|DRUG: Atezolizumab|DRUG: Vemurafenib|DRUG: Bevacizumab|DRUG: Trastuzumab|DRUG: Pertuzumab|DRUG: Cobimetinib|DRUG: 5-FU/LV|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: mFOLFIRINOX Plus Radiotherapy to Patients With CA19-9-normal Advanced Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Adenocarcinoma
Interventions: COMBINATION_PRODUCT: mFOLFIRINOX plus radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Pharmacodynamics Study of SEG101 (Crizanlizumab) in Sickle Cell Disease (SCD) Patients With Vaso- Occlusive Crisis (VOC)
Status: COMPLETED
Conditions: Sickle Cell Disease (SCD)
Interventions: DRUG: crizanlizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of a New Approach to Perform an Esophageal Myotomy: the Transesophageal Submucosa Approach
Status: COMPLETED
Conditions: Esophagus Achalasia
Interventions: PROCEDURE: Peroral endoscopic myotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Proprioceptive Training in Addition to Routine Physical Therapy on Balance and Quality of Life in Patients With Diabetic Peripheral Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathy
Interventions: OTHER: Proprioceptive training|OTHER: routine physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of Agomelatine Sublingual Tablets in the Treatment of Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Agomelatine (AGO178C)|DRUG: Agomelatine (AGO178C)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by CART19
Status: UNKNOWN
Conditions: Hematopoietic/Lymphoid Cancer|Adult Acute Lymphoblastic Leukemia in Remission|B-cell Adult Acute Lymphoblastic Leukemia|B-cell Chronic Lymphocytic Leukemia|Prolymphocytic Leukemia|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Refractory Chronic Lymphocytic Leukemia|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Chronic Lymphocytic Leukemia|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Chronic Lymphocytic Leukemia|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma
Interventions: BIOLOGICAL: anti-CD19-CAR vector-transduced T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Avonex in Subjects With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
Status: COMPLETED
Conditions: Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Interventions: DRUG: Interferon Beta-1a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of ABT-888 Plus Topotecan Hydrochloride to Treat Patients With Solid Tumors and Lymphomas
Status: COMPLETED
Conditions: Solid Tumors|Lymphomas
Interventions: DRUG: ABT-888|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individual vs. Group Community Reinforcement Training to Help Parents of Substance-using Treatment-refusing Youth
Status: COMPLETED
Conditions: Substance Use Disorders|Treatment Refusal
Interventions: BEHAVIORAL: Group Community Reinforcement Training for Parents|BEHAVIORAL: Individual Community Reinforcement Training for Parents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two Low-level Laser Irradiation Protocols on the Rate of Canine Retraction
Status: UNKNOWN
Conditions: Malocclusion
Interventions: OTHER: low-level laser therapy applied on days 0, 3,7,14 & every 2 weeks|OTHER: low-level laser therapy applied every 3 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D as a Nutritional Neoadjuvant During Photodynamic Therapy of Basal Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Basal Cell Carcinoma|Basal Cell Nevus Syndrome
Interventions: DRUG: Dietary Vitamin D3 pre-treatment|RADIATION: Photodynamic therapy|DRUG: Serum Maintenance Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Safety, PK, & PD of ISIS 416858 Administered Subcutaneously to Patients With End-Stage Renal Disease on Hemodialysis
Status: COMPLETED
Conditions: End-stage Renal Disease (ESRD)
Interventions: DRUG: ISIS 416858|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 1/2 Study Evaluating ABT-751 in Combination With Alimta in Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer|NSCLC|Non-Small-Cell Lung Cancer
Interventions: DRUG: ABT-751|DRUG: pemetrexed|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study of REPeat Ablation In Patients With Recurrent PERSistent Atrial Fibrillation: Pulmonary Vein Isolation vs. Adjunct Posterior Wall Isolation (REPAIR PERS-AF Study)
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation, Persistent|Atrial Fibrillation Recurrent
Interventions: PROCEDURE: Radio frequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Clinical Success of Bulk Fil Composite Versus Highly Viscous Glass Ionomer in Primary Class II Molars
Status: RECRUITING
Conditions: Dental Caries Class II
Interventions: OTHER: Palfique Bulk Flow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COMpassion for Psychiatric Disorders And Self-Stigma
Status: RECRUITING
Conditions: Bipolar Disorder|Schizophrenia|Depression|Borderline Personality Disorder|Autism Spectrum Disorder
Interventions: BEHAVIORAL: Compassion Focused Therapy|BEHAVIORAL: Ending Self Stigma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adipose Stromal Cells Injection in the Myocardium for Induction of Revascularization
Status: WITHDRAWN
Conditions: Ischemic Heart Disease|Myocardial Ischemia|Coronary Artery Disease
Interventions: BIOLOGICAL: Stromal Cells Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Stem Cell Transplant in Treating Patients With Progressive or Recurrent Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: melphalan|PROCEDURE: autologous-autologous tandem hematopoietic stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: BIOLOGICAL: BNT116|BIOLOGICAL: Cemiplimab|DRUG: Docetaxel|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adapting Treatment Delivery to Improve Retention in Evidence-Based PTSD Treatment
Status: RECRUITING
Conditions: Stress Disorders, Post-Traumatic
Interventions: OTHER: EBP-Massed|OTHER: EBP-TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DOT Selfie: A Mobile Technology Intervention to Evaluate Treatment Adherence Among Tuberculosis Patients
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DEVICE: DOT Selfie Intervention|OTHER: In-person DOT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Outcomes With Treatment and Withdraw of Ixekizumab in Patients With Plaque Psoriasis
Status: RECRUITING
Conditions: Plaque Psoriasis
Interventions: BIOLOGICAL: Ixekizumab|DRUG: Methotrexate|DRUG: Cyclosporin A|DRUG: Acitretin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Web-Based Education on Patient Empowerment and Asthma Control in Asthma Patients
Status: NOT_YET_RECRUITING
Conditions: Asthma|Patient Empowerment
Interventions: OTHER: web based education|OTHER: Standard education brochure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Relining Assessment of Digital and Conventional Fabricated Complete Denture Base
Status: ACTIVE_NOT_RECRUITING
Conditions: Problem With Dentures
Interventions: OTHER: soft lining of complete denture processed by 3 different techniques.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Nerve Block Anesthesia Combined With Sedative Anesthesia Versus General Anesthesia in Surgery for CSDH
Status: RECRUITING
Conditions: Chronic Subdural Hematoma|Anesthesia
Interventions: PROCEDURE: Cranial Nerve Block Anesthesia Combined With Sedative Anesthesia|PROCEDURE: General Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: tDCS and Pain Associated With Diabetic Neuropathy
Status: UNKNOWN
Conditions: Diabetic Neuropathies|Chronic Pain
Interventions: DEVICE: transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Echinacea as Prophilaxis for Upper Respiratory Tract Infections in Children 1-5 Years
Status: COMPLETED
Conditions: Upper Respiratory Tract Infections
Interventions: DRUG: Echinacea|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Proposal to Examine the Effect of Fecal Transplantation on Obesity
Status: UNKNOWN
Conditions: Disorientation as to People, Time and Place
Interventions: OTHER: fecal material|OTHER: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does Depth of Neuromuscular Blockade (NMB) Affect Surgical Conditions in Obese Patients Undergoing Robotic Surgery
Status: WITHDRAWN
Conditions: GYN Disorders|Urologic Diseases
Interventions: DRUG: NMB with rocuronium bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Characteristics and Mechanism Research of Inhibitors of Janus Kinase in the Idiopathic Inflammatory Myopathies
Status: RECRUITING
Conditions: Idiopathic Inflammatory Myopathies
Interventions: DRUG: tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrical Muscle Stimulation in the Development of Acquired Weakness in Patients With Severe Sepsis and Septic Shock
Status: COMPLETED
Conditions: Polyneuropathies|Septic Shock|Muscle Weakness
Interventions: DEVICE: electrical muscle stimulation|PROCEDURE: conventional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Improving Bone Health Among Rheumatoid Arthritis (RA) Patients on Chronic Glucocorticoids
Status: COMPLETED
Conditions: Adverse Effect of Glucocorticoids and Synthetic Analogues|Osteoporosis|Rheumatoid Arthritis
Interventions: OTHER: Storytelling online video
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Effect of an Antibiotic on the Production of Uremic Toxins by the Gut Microbiome
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DRUG: Vancomycin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study for Palliative/Preventive Treatment of Chronic Back Pain
Status: COMPLETED
Conditions: Supplementation|Back Pain
Interventions: DIETARY_SUPPLEMENT: Experimental product|OTHER: Control product consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Paclitaxel in Advanced Refractory Kaposi's Sarcoma (AIDS-KS): A Phase II Trial of Paclitaxel From Baker Norton Pharmaceuticals
Status: COMPLETED
Conditions: Sarcoma, Kaposi|HIV Infections
Interventions: DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Simultaneous TransPRK and Corneal Collagen Cross-Linking
Status: COMPLETED
Conditions: Keratoconus
Interventions: PROCEDURE: Transepithelial Photorefractive Keratectomy (TransPRK)|PROCEDURE: Corneal Collagen Cross-Linking (CXL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of Salivary Bisphenol-A Levels in Patients With Fixed Lingual, Hawley and Vacuum-formed Retainers
Status: COMPLETED
Conditions: Orthodontic Retention
Interventions: DEVICE: Fixed lingual retainers applied with Bis-GMA containing composite|DEVICE: Fixed lingual retainers applied with Bis-GMA-free composite|DEVICE: Vacuum-formed retainers|DEVICE: Hawley retainers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adapted Physical Activity Program (APA) for Effort Rehabilitation of Children and Teenagers With Osteogenesis Imperfecta
Status: RECRUITING
Conditions: Osteogenesis Imperfecta
Interventions: OTHER: Adapted Physical Activity program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability and Pharmacokinetics (PK) Study of GSK2269557 in Healthy Subjects
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK2269557 500 µg|DRUG: GSK2269557 750 µg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Idazoxan in Healthy Participants
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: TR-01-XRR (1)|DRUG: TR-01-XRR (2)|DRUG: TR-01-XRR (3)|DRUG: TR-01-XRS|DRUG: TR-01-XR|DRUG: TR-01-IR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of a Minimal Psychoeducational Intervention on Anxiety Among Hospitalized COVID-19 Patients in Denmark
Status: UNKNOWN
Conditions: COVID-19|Mental Health|Psychoeducation|Anxiety
Interventions: OTHER: Psychoeducational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of AZD2811 + Durvalumab in ES-SCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: Small-Cell Lung Cancer
Interventions: DRUG: Durvalumab|DRUG: AZD2811|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expanded Access for the Treatment of Advanced Cholangiocarcinoma With ABC294640 (Yeliva ®)
Status: AVAILABLE
Conditions: Cholangiocarcinoma|Cholangiocarcinoma Non-resectable|Cholangiocarcinoma, Perihilar|Cholangiocarcinoma, Extrahepatic|Cholangiocarcinoma, Intrahepatic
Interventions: DRUG: ABC294640
Study Type: EXPANDED_ACCESS
Clinical trial: Hématologie Adulte Prevalence of Adrenal Insufficiency Post-chemotherapy Adrenocorticotropia in Adult Hematology
Status: WITHDRAWN
Conditions: Haematological Malignancy
Interventions: OTHER: Hydrocortisone supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sedation Strategies for Diagnostic Bronchoscopy 2
Status: UNKNOWN
Conditions: Bronchoscopy|Sedation
Interventions: DRUG: Midazolam|DRUG: Fentanyl|DRUG: Dexmedetomidine|DRUG: Remifentanil|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Experimental Dentifrice Remineralization/Fluoride Uptake in an in Situ Model
Status: COMPLETED
Conditions: Dental Erosion
Interventions: DRUG: NaF/ KNO3/isopentane Dentifrice|DRUG: NaF/KNO3 Dentifrice|DRUG: NaF Dentifrice|OTHER: Placebo Dentifrice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Pharmacology Study of Oral Edaravone in Healthy Adult Males (Drug Interaction Study and Preliminary Regimen-Finding Study)
Status: COMPLETED
Conditions: Healthy Adult Subjects
Interventions: DRUG: MT-1186|DRUG: Rosuvastatin|DRUG: Sildenafil|DRUG: Furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pulmonary Rehabilitation in Idiopathic Pulmonary Fibrosis
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: PROCEDURE: Pulmonary rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Myocardial Protection and Anesthetic Agents
Status: COMPLETED
Conditions: Myocardial Ischemic Reperfusion Injury
Interventions: DRUG: Remifentanil|DRUG: Dexmedetomidine|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Role of Transcutaneous Electrical Nerve Stimulation (TENS) for Menstrual Pain Relief
Status: COMPLETED
Conditions: Primary Dysmenorrhea
Interventions: DEVICE: One Unit TENS|DEVICE: Two Unit TENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Periodontal Maintenance Therapy on Tooth Loss in Regular and Irregular Compliant Smokers and Non-Smokers: A Cohort Retrospective Analysis With a Follow-up Up to 40 Years
Status: UNKNOWN
Conditions: Periodontal Diseases|Tooth Loss|Compliance|Smoking
Interventions: OTHER: Maintenance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Weekly Use of Teriparatide to Accelerate Healing of Distal Radius Fracture
Status: UNKNOWN
Conditions: Colles' Fracture
Interventions: DRUG: recombinant teriparatide for injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dietary Interventions, or no Intervention, on Pain and Quality of Life in Women Diagnosed With Endometriosis
Status: COMPLETED
Conditions: Endometriosis
Interventions: OTHER: Low FODMAP diet|OTHER: Endometriosis diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Scaling and Root Planing With and Without Er:YAG Laser in Chronic Periodontitis Patients
Status: UNKNOWN
Conditions: Chronic Periodontitis
Interventions: PROCEDURE: Scaling and Root Planing|DEVICE: Er:YAG Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: OTHER: Nitrous Oxide|OTHER: No Nitrous Oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of KPI-121 in Subjects With Inflammatory Meibomian Gland Disease
Status: COMPLETED
Conditions: Blepharitis
Interventions: DRUG: KPI-121|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Trigger Finger Orthotic Wearing Schedules
Status: COMPLETED
Conditions: Trigger Finger
Interventions: OTHER: Orthotic continuous wear group|OTHER: Orthotic wear during waking hours only group|OTHER: Orthotic wear only while sleeping group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Core Strength Training on the Physical Fitness and Skills of Youth Field Hockey Players in China
Status: RECRUITING
Conditions: Player
Interventions: BEHAVIORAL: core strength training 1-6weeks|BEHAVIORAL: core strength training 7-12weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Believing People Can Change: A Randomized Controlled Trial of an Incremental Theory Intervention in Adolescence
Status: COMPLETED
Conditions: Depressive Symptoms|Happiness|Life Satisfaction
Interventions: OTHER: Growth mindset of personality educational intervention|OTHER: Growth mindset of athletic ability educational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase III Study of AK104 as Adjuvant Therapy in HCC With High Risk of Recurrence After Curative Resection
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: AK104|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT