pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of Canagliflozin and Metformin Immediate Release (150 mg/500 mg) FDC Tablets in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Canagliflozin tablets|DRUG: Metformin IR tablets|DRUG: Canagliflozin/metformin IR FDC tablets|DRUG: Canagliflozin tablets|DRUG: Metformin IR tablets|DRUG: Canagliflozin/metformin IR FDC tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Comparison of the Diagnostic Yield of Small Bowel Pillcam SB2 and Capsocam Capsule
Status: COMPLETED
Conditions: Anemia|Gastrointestinal Bleedings|Méléna|Angiodysplasia|Polyps
Interventions: DEVICE: capsule endoscopies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Oxaliplatin and Sorafenib Combination to Treat Gastric Cancer Relapsed After a Cisplatin Based Treatment
Status: COMPLETED
Conditions: Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma (Relapsed After a Cisplatin Based Treatment)
Interventions: DRUG: Oxaliplatin|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Airway Hyper-responsiveness Study In Asthma Using Salmeterol/Fluticasone Propionate Combination Product
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Salmeterol/fluticasone propionate combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Physician Led Counseling in Management of Depression in Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Depression|Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Physician Supported Care|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Home Monitors Used With Home Oxygen Therapy
Status: NOT_YET_RECRUITING
Conditions: Frequency of Adverse Events, Health Care Utilization, Infant Growth, Parental Quality of Life, and Altitude of the Participant's Home
Interventions: DIAGNOSTIC_TEST: Home Oxygen Monitors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Trial to Evaluate the Pharmacokinetics and Safety of Pyroglutamate Rongliflozin Capsules in Subjects With Mild and Moderate Liver Damage
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: pyroglutamate rongliflozin capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study on the Value of Pelvic Floor Training After Pelvic Organ Prolapse Surgery
Status: UNKNOWN
Conditions: Pelvic Organ Prolapse
Interventions: OTHER: Physiotherapy intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Assessment Trial of COVID-19 Vaccines (COMBAT-COVID)
Status: UNKNOWN
Conditions: COVID 19 Vaccine
Interventions: BIOLOGICAL: BIBP (CNBG, Sinopharm) WIV|BIOLOGICAL: CanSinoBIO|BIOLOGICAL: AstraZeneca ChAdOx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of AccuPAP Device Versus Standard Nebulizer Therapy in Acute Asthma Exacerbation in Children
Status: WITHDRAWN
Conditions: Asthma
Interventions: DEVICE: AccuPAP|DRUG: Albuterol and Ipratropium Continuous Nebulizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Early WBVT on Neuromuscular Control After ACLR
Status: COMPLETED
Conditions: Rupture of Anterior Cruciate Ligament
Interventions: OTHER: Whole body vibration therapy|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of Sensory Based Narrative Intervention
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: OTHER: English Langugae-Sensory based narrative intervention|OTHER: English Language-Narrative intervention|OTHER: Urdu Langusge-Sensory based narrative intervention|OTHER: Urdu Language-Narrative intervention|OTHER: Bilingual-Sensory based narrative intervention|OTHER: Bilingual-Narrative intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peer Navigators to Address Obesity-Related Concerns for African Americans With Serious Mental Illness
Status: COMPLETED
Conditions: Obesity|Mental Disorder
Interventions: BEHAVIORAL: BWLI|BEHAVIORAL: BWLI & Peer Navigator|BEHAVIORAL: Integrated Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Adding Interleukin-2 to an Optimized Antiretroviral Regimen in HIV Patients in Therapeutic Failure (ANRS123)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Interleukin-2 (IL-2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Replacement of Insecticides to Control Visceral Leishmaniasis (VL)
Status: COMPLETED
Conditions: Cost-effective and Sustainable Vector Control Methods Will be Established to Reduce VL in India, Bangladesh and Nepal
Interventions: OTHER: IWFPL|OTHER: IDWL|OTHER: ITN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Prehab Strengthening Program Prior to ACL Surgery on Lower Limb Structure and Function
Status: UNKNOWN
Conditions: ACL Injury
Interventions: BEHAVIORAL: Strengthening|BEHAVIORAL: Conventional
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First-in-Human, Study to Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HM15136 in Healthy Subjects
Status: COMPLETED
Conditions: Pharmacology
Interventions: DRUG: HM15136|DRUG: Placebo of HM15136
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postprandial Hypoglycemia in Patients After Bariatric Surgery With Empagliflozin and Anakinra - The Hypo-BEAR-Study
Status: COMPLETED
Conditions: Postprandial Hypoglycemia|Bariatric Surgery|Late Dumping Syndrome
Interventions: DRUG: Empagliflozin|DRUG: Anakinra|OTHER: oral placebo (winthrop tablet)|OTHER: subcutaneous placebo (0.67 ml of 0.9% sodium chloride)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of Preoperative Scopolamine Patch Application on the Postoperative Nausea and Vomiting in MVD Surgery
Status: UNKNOWN
Conditions: Patients
Interventions: DRUG: Scopolamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Childhood Hepatocellular Carcinoma|Childhood Malignant Liver Neoplasm|Fibrolamellar Carcinoma|Hepatoblastoma|Hepatocellular Malignant Neoplasm, Not Otherwise Specified
Interventions: DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Doxorubicin|DRUG: Etoposide|DRUG: Fluorouracil|DRUG: Gemcitabine|DRUG: Irinotecan|OTHER: Laboratory Biomarker Analysis|DRUG: Oxaliplatin|OTHER: Patient Observation|PROCEDURE: Resection|DRUG: Sorafenib|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Rheumatoid Arthritis With Marine and Botanical Oils
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: fish oil|DRUG: borage seed oil|DRUG: combination fish oil and borage seed oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Effect of M1774 on Hard-to-Treat Refractory SPOP-mutant Prostate Cancer
Status: RECRUITING
Conditions: Refractory Prostate Carcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|DRUG: Tuvusertib|PROCEDURE: Ultrasound Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stress Management in Patients With Coronary Artery Disease
Status: ENROLLING_BY_INVITATION
Conditions: Stress, Psychological
Interventions: BEHAVIORAL: Management of Stress|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Korean Red Ginseng on Male Infertility
Status: COMPLETED
Conditions: Male Infertility
Interventions: DRUG: Korean Red Ginseng, Varicocelectomy|DRUG: Placebo|PROCEDURE: Varicocelectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of MTPS9579A in Patients With Asthma Requiring Inhaled Corticosteroids and a Second Controller
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: MTPS9579A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gastric Insufflation During Positive Pressure Ventilation
Status: UNKNOWN
Conditions: Gastric Insufflation
Interventions: DIAGNOSTIC_TEST: ultrasound examination of air insufflation in the upper esophageal region and stomach
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of High Protein Diet on Cardiovascular Diseases Risk Factors Among Overweight and Obese Children
Status: COMPLETED
Conditions: Body Mass Index Quantitative Trait Locus 7 Disorder|Tangier Disease
Interventions: OTHER: nutrition intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Improving Treatment Outcomes for Suicidal Veterans With PTSD
Status: ACTIVE_NOT_RECRUITING
Conditions: Suicidal Ideation|Suicide, Attempted|Ptsd
Interventions: BEHAVIORAL: Cognitive Processing Therapy (CPT)|BEHAVIORAL: Crisis Response Plan (CRP)|BEHAVIORAL: Safety Planning Intervention (SPI)|BEHAVIORAL: Narrative Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BIBF 1120 for Recurrent High-Grade Gliomas
Status: COMPLETED
Conditions: Glioblastoma|Gliosarcoma|Anaplastic Astrocytoma|Anaplastic Oligodendroglioma|Anaplastic Oligoastrocytoma
Interventions: DRUG: BIBF 1120
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HLX07+HLX10+Chemotherapy or HLX07 Monotherapy in Patients With Advanced Metastatic Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer (GC) Gastroesophageal Junction Cancer (GEJ)
Interventions: DRUG: HLX07+HLX10+oxaliplatin+capecitabine|DRUG: HLX07
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Warming Measures in Cesarean Delivery
Status: RECRUITING
Conditions: Hypothermia; Anesthesia|Hypothermia, Newborn|Hypothermia, Sequela
Interventions: DEVICE: Pre op upper body forced air warming (32˚C)|DEVICE: Pre op lower body forced air warming (32˚C)|DEVICE: Pre op fluids (45˚C)|DEVICE: Intra op upper body forced air warming (32˚C)|DEVICE: Intra op fluids at room temperature|DEVICE: Intra op upper body forced air warming at (32˚C)|DEVICE: Intra op upper body forced air warming at (42˚C)|DEVICE: Intra op lower body forced air warming at (32˚C)|DEVICE: Intra op lower body forced air warming at (42˚C)|DEVICE: Intra op fluid (42˚C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Glucagon-like Peptide 1 (GLP-1) on Microvascular Myocardial Function in Patients With Type 2 Diabetes.
Status: COMPLETED
Conditions: Type 2 Diabetes|Microvascular Dysfunction
Interventions: DRUG: Victoza
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TraStuzumAb-Radiotherapy : Impact on the Cerebral Prevention
Status: TERMINATED
Conditions: Breast Cancer|Metastasis|Sur-expressing Her2-neu
Interventions: RADIATION: cerebral prophylactic radiation|DRUG: Trastuzumab|DRUG: Other chemotherapy in association with Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Tolerability, Safety and Immunogenicity of the Flu-M Vaccine in Children Between 6 Months and 9 Years Old
Status: COMPLETED
Conditions: Influenza, Human|Vaccination; Infection|Vaccines
Interventions: BIOLOGICAL: Flu-M, Inactivated split influenza vaccine 0.5 mL|BIOLOGICAL: Vaxigrip, Inactivated split influenza vaccine 0.5 mL|BIOLOGICAL: Flu-M, Inactivated split influenza vaccine 0.25 mL|BIOLOGICAL: Vaxigrip, Inactivated split influenza vaccine 0.25 mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Erlotinib Hydrochloride in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Completely Removed by Surgery (An ALCHEMIST Treatment Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Non-Squamous Non-Small Cell Carcinoma|Stage IB Lung Non-Small Cell Carcinoma AJCC v7|Stage II Lung Non-Small Cell Cancer AJCC v7|Stage IIA Lung Non-Small Cell Carcinoma AJCC v7|Stage IIB Lung Non-Small Cell Carcinoma AJCC v7|Stage IIIA Lung Non-Small Cell Cancer AJCC v7
Interventions: OTHER: Clinical Observation|DRUG: Erlotinib Hydrochloride|OTHER: Laboratory Biomarker Analysis|OTHER: Placebo Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Microfinance Intervention for Vulnerable Women in Kazakhstan
Status: COMPLETED
Conditions: HIV/AIDS and Infections
Interventions: BEHAVIORAL: Microfinance intervention (MF)|BEHAVIORAL: HIV risk reduction (HIVRR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PET/CT Guided Fulvestrant Therapy for Patients With Recurrent or Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: PROCEDURE: Diagnostic Imaging: 18F-FDG PET/CT Scan - Baseline|PROCEDURE: Diagnostic Imaging: 18F-FES PET/CT - Baseline|PROCEDURE: Diagnostic Imaging: 18F-FES PET/CT - 3 month follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Role of Regulatory T Cell in Ovarian Cancer: Focus on Relationship Between Clinical Prognosis and Regulatory T Cell Expression
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: PROCEDURE: Staging surgery or debulking surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A First Time in Human Study Exploring Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of GSK2618960 in Healthy Volunteers and Patients With Relapsing Remitting Multiple Sclerosis (RRMS)
Status: TERMINATED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Part A: 100 mg/mL GSK2618960|DRUG: Part A: matching placebo|DRUG: Part B: Dose of GSK2618960 decided from Part A|DRUG: Part B: matching placebo|DRUG: Part C: Dose of GSK2618960 decided from Part A and B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Safety and Tolerability of CBLB502 as a Neo-adjuvant Treatment in Patients With Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: CBLB502|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pramlintide on Prevention of Weight Gain Early Onset of Type 1 Diabetes
Status: WITHDRAWN
Conditions: Type 1 Diabetes
Interventions: DRUG: Pramlintide|DRUG: Glargine|DRUG: Lispro|DRUG: Aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigator Initiated Prospective, Four Arms Randomized Comparative Study of Efficacy and Safety of Saroglitazar, Vitamin E and Life Style Modification in Patients With Nonalcoholic Fatty Liver Disease (NAFLD)/ Non-alcoholic Steatohepatitis (NASH)
Status: UNKNOWN
Conditions: NAFLD
Interventions: DRUG: Saroglitazar|DRUG: Vitamin E|DRUG: Combination drug|BEHAVIORAL: Lifestyle Changes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intervention for Depressed Latina Mothers of Children With Asthma
Status: COMPLETED
Conditions: Pediatric Asthma|Maternal Depression
Interventions: BEHAVIORAL: MAADRE|BEHAVIORAL: MAAS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Implant Surface Characteristics in Patients With History of Periodontitis
Status: COMPLETED
Conditions: Marginal Bone Loss
Interventions: PROCEDURE: Implant placement surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maternal Immunization To Prevent Infant Otitis Media
Status: COMPLETED
Conditions: Otitis Media
Interventions: BIOLOGICAL: PNCRM9|BIOLOGICAL: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Sintilimab Plus Lenvatinib as Adjuvant Therapy in Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis (PVTT) After Surgical Resection
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Sintilimab|DRUG: Lenvatinib|PROCEDURE: Transarterial Chemoembolization (TACE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Human Alkaline Phosphatase in Healthy Japanese Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: single 1-hour IV infusion of 0.8 mg/kg recAP|BIOLOGICAL: single 1-hour IV infusion of 1.6 mg/kg recAP|BIOLOGICAL: single 1-hour IV infusion of 3.2 mg/kg recAP|BIOLOGICAL: 1-hour infusions of 1.6 mg/kg recAP on Days 1, 2 and 3|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tumor-Infiltrating Lymphocytes After Combination Chemotherapy in Treating Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Stage III Cutaneous Melanoma AJCC v7|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7|Metastatic Melanoma
Interventions: BIOLOGICAL: Aldesleukin|DRUG: Cyclophosphamide|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Therapeutic Tumor Infiltrating Lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Study of Durvalumab(MEDI4736) and Tremelimumab in Chinese Patients With Advanced Malignancies
Status: COMPLETED
Conditions: Advanced Malignancy
Interventions: DRUG: durvalumab|DRUG: tremelimumab + durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Postbiotic Intake on Glucose Control and Microbiota Composition of Type 2 Diabetic Subjects: a Randomized Controlled Trial.
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DIETARY_SUPPLEMENT: Postbiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia in Patients at High-risk of OSA
Status: NOT_YET_RECRUITING
Conditions: Obstructive Sleep Apnea|Surgery|Dexmedetomidine|Esketamine|Postoperative Sleep Quality
Interventions: DRUG: Dexmedetomidine-esketamine combination|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose Study of ACAM2000 Smallpox Vaccine in Previously Vaccinated Adults
Status: COMPLETED
Conditions: Smallpox
Interventions: BIOLOGICAL: ACAM2000 Smallpox Vaccine|BIOLOGICAL: Vaccinia virus (calf lymph) smallpox vaccine: Dryvax®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of BTD and BCD Based Regimens in the Treatment of AL Amyloidosis
Status: UNKNOWN
Conditions: Immunoglobulin Light-Chain Amyloidosis
Interventions: DRUG: Thalidomide|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Unblinded Trial of Zidovudine Versus ddC in the Treatment of Patients Status Post PCP Who Received Long-Term Zidovudine Therapy in Protocol ACTG 002
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zidovudine|DRUG: Zalcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Tendon Fenestration Versus Surgery for the Treatment of Chronic Lateral Epicondylosis
Status: COMPLETED
Conditions: Epicondylitis of the Elbow|Tennis Elbow
Interventions: PROCEDURE: Mini-open surgery|DEVICE: Ultrasound-guided Tendon fenestration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pregabalin for Postoperative Pain in Women Undergoing Breast Cancer Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Placebo|DRUG: Pregabalin 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interventional Study to Evaluate the Effect of the Oral Administration of L.Plantarum on Vaginal Microbiota
Status: COMPLETED
Conditions: Vaginal Infection
Interventions: DIETARY_SUPPLEMENT: Lactobacillus plantarum
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Provider Training in Increasing Patient Tobacco Cessation Counseling and Referrals for Patients With Cancer Undergoing Radiation Therapy
Status: COMPLETED
Conditions: Breast Carcinoma|Caregiver|Head and Neck Carcinoma|Lung Carcinoma|Prostate Carcinoma|Tobacco Use
Interventions: OTHER: Communication Skills Training|OTHER: Medical Chart Review|OTHER: Questionnaire Administration|OTHER: Tobacco Cessation Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Bracing Versus No Bracing in Stable Thoracolumbar Compression and Burst Fractures
Status: TERMINATED
Conditions: Thoracic Fracture|Lumbar Fracture|Compression Fracture of Thoracic Vertebral Body|Compression Fracture of Lumbar Spine|Burst Fracture of Thoracic Vertebra|Burst Fracture of Lumbar Vertebra
Interventions: OTHER: Spinal Orthosis (LSO, TLSO)|OTHER: No orthosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Compared With Standard Duration of Antibiotic Treatment for AECOPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Levofloxacin 500mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determining the Effect of Actimmune (Interferon Gamma 1b)Dose Titration on Flu-Like Symptoms in Healthy Volunteers
Status: UNKNOWN
Conditions: Adverse Effects in the Therapeutic Use of Interferon
Interventions: DRUG: interferon gamma 1b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of SOD Enzyme on Frailty and HRQOL Among Indonesian Pre-frail Elderly: A Double Blind Randomized Controlled Trial
Status: UNKNOWN
Conditions: Pre-frail Elderly
Interventions: DIETARY_SUPPLEMENT: SOD+Gliadin Capsule|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Simulators Used in Fiber-optic Intubation Training Among Anesthesia Residents
Status: UNKNOWN
Conditions: Fiber-optic Intubation
Interventions: OTHER: didactic teaching and simulator practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Discontinuation of Hypomethylating Agent and Venetoclax in Patients With AML MRD
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|DRUG: Decitabine|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Tedizolid Phosphate in Adolescents With Complicated Skin and Soft Tissue Infection (cSSTI) (MK-1986-012)
Status: COMPLETED
Conditions: Skin Diseases, Infectious|Skin Diseases, Bacterial
Interventions: DRUG: Tedizolid Phophate|DRUG: Antibiotic comparator|DRUG: Aztreonam|DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Of The Effect Of CE-224535 On Knee OA (Osteoarthritis) Pain
Status: TERMINATED
Conditions: Osteoarthritis
Interventions: DRUG: naproxen|DRUG: CE-224535|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ixazomib, Given With Dexamethasone in Adults With Multiple Myeloma
Status: COMPLETED
Conditions: Relapsed and/or Refractory Multiple Myeloma
Interventions: DRUG: Ixazomib|DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Interstitial Laser Thermal Therapy Under Continuous MRI Monitoring as a Minimally Invasive Treatment of Patients With Medically Unbalanced Partial Epilepsy
Status: UNKNOWN
Conditions: Drug-resistant Focal Epilepsy|Epilepsy|Epilepsies, Focal|Focal Epilepsy|Drug Resistant
Interventions: PROCEDURE: Laser technology for intracerebral thermocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Creation of a Shared Medical Decision-making Tool for Atopic Dermatitis
Status: UNKNOWN
Conditions: Atopic Dermatitis
Interventions: OTHER: Audio recordings during the consultations|OTHER: Audio recordings during the consultations and test of the shared medical decision-making tool for modification|OTHER: Audio recordings during the consultations and test of the shared medical decision-making tool for validation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TRUST Study: Raptiva ® in Hand & Foot Psoriasis
Status: TERMINATED
Conditions: Chronic Plaque Psoriasis
Interventions: DRUG: Efalizumab - anti CD11a recombinant human monoclonal antibody|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sildenafil and Uteroplacental Perfusion
Status: UNKNOWN
Conditions: Fetal Growth Retardation
Interventions: DRUG: sildenafil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM)
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer
Interventions: PROCEDURE: Colonoscopy|PROCEDURE: FIT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Characteristics of Hypophosphatasia in Adult Patients in Rheumatology and Their Value in Developing an Algorithm to HPP-diagnosis - the COHIR Multi-center Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypophosphatasia
Interventions: DIAGNOSTIC_TEST: Second alkaline phosphatase measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Evaluation of Investigational Multifocal Toric Contact Lenses
Status: COMPLETED
Conditions: Presbyopia|Astigmatism
Interventions: DEVICE: comfilcon A multifocal toric lens|DEVICE: omafilcon A Multifocal Toric Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation for Treating Depression: A Functional Magnetic Resonance Imaging Study
Status: TERMINATED
Conditions: Major Depressive Disorder
Interventions: DEVICE: Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Effectiveness of Agilus (Hyaluronic Acid) for Ankle Osteoarthritis
Status: TERMINATED
Conditions: OSTEOARTHRITIS
Interventions: DEVICE: Agilus|DEVICE: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Safety and Efficacy of the Treatment With the Selution Sirolimus Coated Balloon in TASC C and D Tibial Occlusive Disease in Patients With Critical Limb Ischemia From Singapore
Status: COMPLETED
Conditions: Critical Limb Ischemia
Interventions: DEVICE: Drug Coated Balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OFA - Opioid Free Anesthesia
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Remifentanil|DRUG: Ketamine|DRUG: Lidocaine|DRUG: Clonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Assessment of Myocardial Stiffness by 2D-SWE Ultrasound Technique (Bidimensional Shear Wave Elastography) in Patients With Transthyretin Amyloidosis
Status: UNKNOWN
Conditions: Amyloidosis
Interventions: PROCEDURE: Shear wave elastography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of 3 Doses of HL10 Given at Fixed Time Intervals Compared to Standard Therapy
Status: TERMINATED
Conditions: Acute Lung Injury|Acute Respiratory Distress Syndrome
Interventions: DRUG: HL 10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study for the Treatment of Severe Pulmonary Embolism With Pharmacodynamic Thrombectomy
Status: UNKNOWN
Conditions: Pulmonary Embolism
Interventions: DEVICE: Pharmacodynamic thrombectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment With Peginterferon Alfa-2a (40 KD) of Chronic Hepatitis B Patients, Who Have Failed Anti-viral Treatment
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: Pegylated Interferon-alfa-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Using Walking Aid on Mobility
Status: COMPLETED
Conditions: Coronary Artery Bypass Graft Surgery|Pain|Early Mobilization|Walking, Difficulty
Interventions: DEVICE: using a walking aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomized Double-blind Trial of Midazolam and Loxapine in Agitated Patients
Status: TERMINATED
Conditions: Acute Agitated Patients
Interventions: DRUG: loxapine, midazolam|BIOLOGICAL: blood sample|OTHER: patient monitoring|DRUG: Loxapine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Music Therapy to Ease Pain and Emotional Distress in Patients With Hematologic Cancer Who Are Undergoing High-Dose Therapy and Stem Cell Transplantation
Status: COMPLETED
Conditions: Anxiety Disorder|Chronic Myeloproliferative Disorders|Depression|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Pain
Interventions: PROCEDURE: pain therapy|PROCEDURE: psychosocial assessment and care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose:
Clinical trial: A Study of the Safety and Efficacy of ONO-4641 in Patients With Relapsing-Remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: ONO-4641|DRUG: ONO-4641|DRUG: ONO-4641|DRUG: ONO-4641 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Clinical Study of SNS-595 for Second-Line Therapy in Patients With Advanced NSCLC
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: SNS-595 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decongestive Exercise and Compression for Breast Cancer Related Lymphedema Management
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Neoplasm|Lymphedema
Interventions: BEHAVIORAL: Standard Care|BEHAVIORAL: Exercise and Compression Garment|BEHAVIORAL: Exercise and Adjustable Compression Wrap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Observational Study of MabThera Subcutaneous (SC) Safety in Participants With Non-Hodgkin's Lymphoma (NHL) or Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin|Leukemia, Lymphocytic, Chronic, B-Cell
Interventions: DRUG: MabThera
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Non-myeloablative Haploidentical HCT Study for Patients With Sickle Cell Disease, Including Compromised Organ Function
Status: RECRUITING
Conditions: Sickle Cell Disease
Interventions: DRUG: Non-myeloablative haploidentical peripheral blood stem cell transplantation with briquilimab and abatacept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Deep Serratus Anterior Plane Block and Superficial Serratus Anterior Plane Block
Status: COMPLETED
Conditions: Pain, Postoperative|Serratus Anterior Plane Block|Thoracic Surgery, Video-Assisted
Interventions: PROCEDURE: Two different blocks with same local anesthetic volume
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reduced Exposure Study in Smokers Using the Tobacco Heating System 2.2 (THS 2.2) for 5 Days in a Confinement Setting
Status: COMPLETED
Conditions: Smoking
Interventions: OTHER: Tobacco Heating System (THS 2.2)|OTHER: Smoking abstinence (SA)|OTHER: Conventional cigarette (CC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Surgical Excision vs Neoadjuvant Radiotherapy+Delayed Surgical Excision of Ductal Carcinoma
Status: RECRUITING
Conditions: Ductal Breast Carcinoma in Situ
Interventions: PROCEDURE: Lumpectomy|RADIATION: Partial breast irradiation prior to surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dual Site-dual Channel Non-invasive Brain Stimulation for Language and Cognitive Function in Stroke Patients
Status: COMPLETED
Conditions: Stroke|Aphasia|Cognitive Impairment
Interventions: DEVICE: IFG stimulation|DEVICE: DLPFC stimulation|BEHAVIORAL: aphasia therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial for Safety and Immunogenicity of a Chikungunya Vaccine, VRC-CHKVLP059-00-VP, in Healthy Adults
Status: COMPLETED
Conditions: Chikungunya Virus Infection
Interventions: BIOLOGICAL: VRC-CHKVLP059-00-VP|OTHER: VRC-PBSPLA043-00-VP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CT-2103 in Treating Patients With Recurrent or Persistent Ovarian Epithelial Cancer or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Primary Peritoneal Carcinoma|Recurrent Ovarian Carcinoma
Interventions: DRUG: Paclitaxel Poliglumex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diabetes Communication and Treatment Burden
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Multiple Chronic Conditions
Interventions: OTHER: CI-PVP (context-informed pre-visit planning)|OTHER: Standard PVP (pre-visit planning)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Data Collection for the Closed Loop Development for the Type 2 Diabetes Treatment - DT2_1
Status: COMPLETED
Conditions: Type 2 Diabetes Treated With Insulin
Interventions: DEVICE: Actimetry|OTHER: Questionnaires|OTHER: Glucose level and insulin administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Oncoxin® and Quality of Life in Cancer Patients
Status: COMPLETED
Conditions: Gastric Cancer Stage II|Non-small Cell Lung Cancer Stage II|Non-small Cell Lung Cancer Stage III|Gastric Cancer Stage III
Interventions: DIETARY_SUPPLEMENT: ONCOXIN®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Atazanavir and Lamivudine for Treatment Simplification
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Lamiduvine (Epivir)|DRUG: Atazanavir (Reyataz)|DRUG: Ritonavir (Norvir)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Efficacy and Safety Study of Compound Carraghenates Cream With Mayinglong Musk Hemorrhoid Ointment in the Treatment of Hemorrhoids
Status: COMPLETED
Conditions: Hemorrhoids
Interventions: DRUG: Carraghenates Cream|DRUG: Mayinglong Musk Hemorrhoid Ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Natural History of Eosinophilic Esophagitis
Status: COMPLETED
Conditions: Eosinophilic Esophagitis
Interventions: DIAGNOSTIC_TEST: Barium Esophagram|DEVICE: EsophaCap|DIAGNOSTIC_TEST: Physical Examination and Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity
Status: TERMINATED
Conditions: Bacterial Vaginosis|Premature Birth|Sepsis|Periventricular Leukomalacia|Bronchopulmonary Dysplasia
Interventions: DRUG: Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neural Integrity Monitor Electromyogram (NIM-EMG) Endotracheal Tube Intubation With Video Laryngoscope
Status: COMPLETED
Conditions: Intubation; Difficult or Failed|Airway Complication of Anesthesia|Pain, Postoperative|Anesthesia Intubation Complication
Interventions: DEVICE: Macintosh Laryngoscope|DEVICE: Video Laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Optical Coherence Tomography in Cerebral Amyloidosis
Status: UNKNOWN
Conditions: Alzheimer Disease|Dementia Alzheimers|Dementia|Lewy Body Disease|Dementia, Lewy Body|Mild Cognitive Impairment
Interventions: DIAGNOSTIC_TEST: non-invasive retinal imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Lactobacillus Reuteri ATCC PTA 6475 on Volumetric Bone Mineral Density in Patients With Osteopenia
Status: COMPLETED
Conditions: Osteopenia
Interventions: DIETARY_SUPPLEMENT: L. reuteri|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multiple Dose Trial Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-04457845 in Healthy Volunteers
Status: COMPLETED
Conditions: Acute Pain|Chronic Pain
Interventions: DRUG: PF-04457845, FAAH inhibitor|DRUG: PF-04457845, FAAH inhibitor|DRUG: PF-04457845, FAAH inhibitor|DRUG: PF-04457845, FAAH inhibitor|DRUG: PF-04457845, FAAH inhibitor|DRUG: PF-04457845, FAAH inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Posterior Capsule Opafication of Different Hydrophobic Acrylic Intraocular Lenses: Vivinex iSert P261 vs.Clareon IOL
Status: UNKNOWN
Conditions: Age Related Cataracts
Interventions: DEVICE: Alcon Clareon|DEVICE: Hoya Vivinex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Parent Artery Reconstruction for Cerebral Aneurysms Using a Novel Flow Diverter With Surface Modification
Status: ACTIVE_NOT_RECRUITING
Conditions: Cerebral Aneurysm|Cerebral Aneurysm Unruptured
Interventions: DEVICE: Cerebral flow diverter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Change of Fructose to Fat in South Asians
Status: COMPLETED
Conditions: Elevated Triglycerides|Diabetes|Cardiovascular Disease|Dyslipidemia
Interventions: OTHER: Fructose + Glucose Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Examining the Effectiveness of Education Based on Social Learning Theory in Fostering Self-care and Social Skills
Status: COMPLETED
Conditions: Main Heading (Descriptor) Terms
Interventions: BEHAVIORAL: Self-Care Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Endoscopic Ultrasound Guided Radio Frequency Ablation of Pancreatic Neuroendocrine Neoplasms
Status: RECRUITING
Conditions: Pancreatic Neuroendocrine Tumors, WHO Grade I-II
Interventions: DEVICE: Radio frequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT