pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Glaucoma Rehabilitation Using ElectricAI Transcranial Stimulation (GREAT) - Randomized Controlled Trial Using Combined Perceptual Learning and Transcranial Electrical Stimulation for Vision Enhancement
Status: RECRUITING
Conditions: Glaucoma
Interventions: OTHER: Real-PL training + Real-tES(tDCS)|OTHER: Real-PL training + Sham-tES (tDCS)|OTHER: Placebo-PL training + Sham-tES (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Compare Safety and Efficacy of OPT-80(Fidaxomicin) With Vancomycin in Subjects With Clostridium Difficile-associated Diarrhea (CDAD)
Status: COMPLETED
Conditions: Clostridium Difficile
Interventions: DRUG: OPT-80|DRUG: vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Auto Continuous Positive Airway Pressure (CPAP)
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: CPAP|DEVICE: autoCPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Octagam 10% Therapy in COVID-19 Patients With Severe Disease Progression
Status: COMPLETED
Conditions: Covid-19
Interventions: BIOLOGICAL: Octagam 10%|OTHER: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Changes in Immunologic Parameters Following the Addition of Fostemsavir in Virologically Suppressed Immunologic Non-responders Living With HIV-the RECOVER Study
Status: RECRUITING
Conditions: HIV-1-infection
Interventions: DRUG: Fostemsavir 600 MG [Rukobia]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Natural Supplement Containing Chlorogenic Acid and Luteolin on Cardio-metabolic Risk Factors
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Natural supplement containing chlorogenic acid and luteolin|OTHER: Placebo (without any active ingredients)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Physiological Flow of Liquids Used in Dysphagia Management (Neuro)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis|Parkinson Disease|Dysphagia
Interventions: DIAGNOSTIC_TEST: Videofluoroscopic Swallowing Examination|OTHER: Tongue Strength Measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Drug-Drug Interaction Study to Assess the CYP1A2 and CYP3A4 Interaction Potential of TEV-56286 (anle138b)
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: anle138b (TEV-56286)|DRUG: Fluvoxamine 100 mg QD for 5 days
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Describe Risk of Bleeding in Patients Depending on the Different Anticoagulant Therapy They Are on for Atrial Fibrillation (AF)
Status: WITHDRAWN
Conditions: Non-valvular Atrial Fibrillation
Interventions: OTHER: Non-interventional|OTHER: Non-Interventional
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy Study of Paricalcitol Versus Calcitriol in the Treatment of Secondary Hyperparathyroidism
Status: COMPLETED
Conditions: Hyperparathyroidism|Kidney Disease
Interventions: DRUG: Paricalitol|DRUG: Calcitriol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pycnogenol and Endothelial Function in Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Pycnogenol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Driving Pressure-guided Tidal Volume Ventilation in the Acute Respiratory Distress Syndrome
Status: NOT_YET_RECRUITING
Conditions: Acute Respiratory Distress Syndrome ARDS
Interventions: OTHER: Tidal volume customization in the acute respiratory distress syndrome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vegetable Signature From Human Metabolomics Responses
Status: COMPLETED
Conditions: Vegetable Signature Documentation With Metabolomic Technique
Interventions: OTHER: Control|OTHER: Spinach|OTHER: Celery|OTHER: Onion|OTHER: Mixed Vegetables
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 3 Study of NBI-98854 for the Treatment of Tardive Dyskinesia
Status: COMPLETED
Conditions: Tardive Dyskinesia
Interventions: DRUG: NBI-98854|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Neoplasms
Interventions: BIOLOGICAL: pembrolizumab|DRUG: paclitaxel|DRUG: nab-paclitaxel|DRUG: liposomal doxorubicin|DRUG: capecitabine|DRUG: normal saline|DRUG: dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone Treatment for Congenital Heart Block (CHB) in Newborns With Lupus
Status: COMPLETED
Conditions: Congenital Heart Block|Neonatal Lupus|Atrioventricular Nodal Dysfunction|Myocardial Injury
Interventions: DRUG: Dexamethasone or other corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HIV-1-Gag Conserved-Element DNA Vaccine (p24CE) Vaccine Study
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: p24CE1/2 pDNA vaccine|BIOLOGICAL: p24CE1/2 pDNA vaccine admixed with full-length p55^gag pDNA vaccine|BIOLOGICAL: Full-length p55^gag pDNA vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ridge Preservation Following Tooth Extraction Using Two Mineralized Cancellous Bone Allografts
Status: COMPLETED
Conditions: Alveolar Bone Loss
Interventions: DEVICE: PUROS (Ridge Preservation bone grafting surgery)|DEVICE: FDBA (Ridge Preservation bone grafting surgery)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Testing of a Peer-Coaching Model for the Treatment of Eating Disorders
Status: ENROLLING_BY_INVITATION
Conditions: Eating Disorder
Interventions: BEHAVIORAL: Parent Coaching and Patient Education|BEHAVIORAL: Parent Education and Patient Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Probiotics in Preventing Oral Mucositis
Status: UNKNOWN
Conditions: Head-and-neck Cancer
Interventions: DRUG: Lactobacillus Reuteri Oral Solution [BioGaia]|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Survival of Implant-Supported All-Ceramic Prostheses
Status: ACTIVE_NOT_RECRUITING
Conditions: Partial Edentulism|Disorder of Prostheses and Implants|Dental Prosthesis Failure
Interventions: DEVICE: Ceramic-Ceramic|DEVICE: Metal-Ceramic
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Stand-alone Left Atrial Appendage Occlusion for Thromboembolism Prevention
Status: RECRUITING
Conditions: Atrial Fibrillation|Stroke
Interventions: DEVICE: Totally thoracoscopic LAAO - ATRICLIP|DEVICE: Percutaneous LAAO - WATCHMAN|DEVICE: Hybrid- minimally invasive LAAO - LARIAT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Zip-Stitch™ for Vaginal Cuff Closure in Total Laparoscopic Hysterectomy
Status: COMPLETED
Conditions: Total Laparoscopic Hysterectomy
Interventions: DEVICE: Zip-Stitch Soft Tissue Closure System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Relative Bioavailability of ESK-001 Tablet Versus Liquid in Healthy Participants
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: ESK-001|DRUG: Rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: GELAD Chemotherapy and Sandwiched Radiotherapy in the Treatment of Stage IE/IIE Natural Killer/T-cell Lymphoma
Status: COMPLETED
Conditions: Extranodal NK-T-Cell Lymphoma, Nasal Type
Interventions: DRUG: GELAD|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension|Systemic Sclerosis|Scleroderma Spectrum of Diseases|Connective Tissue Disease|Pulmonary Hypertension
Interventions: DRUG: tadalafil and ambrisentan upfront combination therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Covid-19, Hospitalized, PatIents, Nasafytol
Status: COMPLETED
Conditions: Coronavirus Infection
Interventions: DIETARY_SUPPLEMENT: NASAFYTOL®|DIETARY_SUPPLEMENT: FULTIUM® -D3 800|DRUG: Strandard of care treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Safety, Pharmacokinetic and Efficacy Study of NUC-3373 in Combination With Standard Agents Used in Colorectal Cancer Treatment
Status: COMPLETED
Conditions: Colorectal Cancer|Colorectal Neoplasms|Colorectal Carcinoma|Colorectal Tumors|Neoplasms, Colorectal
Interventions: DRUG: NUC-3373 + leucovorin|DRUG: NUC-3373|DRUG: NUFOX|DRUG: NUFOX + VEGF pathway inhibitor|DRUG: NUFOX + EGFR inhibitor|DRUG: NUFIRI|DRUG: NUFIRI + VEGF pathway inhibitor|DRUG: NUFIRI + EGFR inhibitor|DRUG: NUC-3373 + bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic TCM for Mitigation of EGFR-TKI Related Dermatological Adverse Effect
Status: COMPLETED
Conditions: Advanced Lung Adenocarcinoma
Interventions: DRUG: TCM Formula|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Study to Examine the Post-Dose Changes in Exhaled Nitric Oxide (eNO) Following Treatment With Fluticasone Propionate (FP)/Salmeterol (SAL) Combination Product Advair
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: fluticasone propionate/salmeterol (Flu/Sal) : 100mcg/50mcg, 250mcg/50mcg,500mcg/50 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fluoroquinolone Associated Disability
Status: COMPLETED
Conditions: Bronchitis|Sinusitis|Urinary Tract Infections
Interventions: DRUG: Fluoroquinolone (FQ)|DRUG: Azithromycin (AZ)|DRUG: Sulfamethoxazole/Trimethoprim (ST) Fixed Dose Combination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase III Trial Assessing the Efficacy and Safety of PXT3003 in CMT1A Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Charcot-Marie-Tooth Disease
Interventions: DRUG: (RS)-baclofen, naltrexone hydrochloride and D-sorbitol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Modulation of Brain Plasticity After Perinatal Stroke
Status: UNKNOWN
Conditions: Stroke|Cerebral Palsy
Interventions: PROCEDURE: Repetitive Transcranial Magnetic Stimulation (rTMS)|PROCEDURE: Constraint-induced movement therapy (CIMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Changes in Dialysate Bicarbonate on Serum Calcification Propensity and Calciprotein Particles in Hemodialysis Patients
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: OTHER: Dialysate bicarbonate modification
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Hysterectomy by Transvaginal Natural Orifice Transluminal Endoscopic Surgery Versus or Laparoscopic Hysterectomy
Status: NOT_YET_RECRUITING
Conditions: Hysteromyoma
Interventions: PROCEDURE: vNOTES : natural vaginal orifice transluminal endoscopic system for hysterectomies|PROCEDURE: laparoscopic hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Body Weight Supported Treadmill Training in Stroke Patients
Status: COMPLETED
Conditions: Stroke|Cerebrovascular Accident|Gait Disorders, Neurologic|Walking, Difficulty
Interventions: BEHAVIORAL: Bodyweight supported treadmill training (BWSTT)|BEHAVIORAL: Conventional rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short-Term Effects of Whole-Body Vibration on Upper Extremity Function in Subjects With Poststroke Hemiplegia
Status: UNKNOWN
Conditions: Rehabilitation|Stroke|Hemiplegia|Physical Therapy Modalities|Electromyography|Upper Extremity|Recovery of Function|Vibration
Interventions: DEVICE: whole-body vibration training|OTHER: conventional upper limb training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Impact of Evidence-based Information About Mammography on Breast Cancer Screening Decisions
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: Evidence-based information|BEHAVIORAL: Patient Decision Aid|OTHER: Sham information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Impact of tDCS on Emotional Processing in Major Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Heart Rehabilitation for All
Status: ACTIVE_NOT_RECRUITING
Conditions: Ischemic Heart Disease|Cardiac Valve Surgery|Persistent Atrial Fibrillation|Heart Failure
Interventions: OTHER: Patient-targeted rehabilitation offers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Antiarrhythmic Effects of N-3 Fatty Acids
Status: COMPLETED
Conditions: Arrhythmia|Heart Diseases|Tachycardia, Ventricular|Ventricular Fibrillation
Interventions: BEHAVIORAL: dietary n-3 polyunsaturated fatty acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: FAME: Functional Assessment of a Myoelectric Orthosis Hand Orthoses
Status: TERMINATED
Conditions: Paresis|Stroke
Interventions: DEVICE: Myoelectric UE Device-UE Orthosis-No Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cryoablation of Intercostal Nerves for Post-Operative Pain Management in Opioid-Tolerant Patients
Status: ENROLLING_BY_INVITATION
Conditions: Pain|Pain, Postoperative
Interventions: DEVICE: cryoSPHERE Ablation|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of SLT in Patients With Insufficient IOP Control Under Maximum Tolerated Drug Therapy (Eye Drops)
Status: COMPLETED
Conditions: Glaucoma
Interventions: DEVICE: selective Laser Trabeculoplasty (SLT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Luspatercept (ACE-536) in Chinese Participants Who Require Regular Red Blood Cell Transfusions Due to Beta (β)-Thalassemia.
Status: RECRUITING
Conditions: Beta-thalassemia
Interventions: DRUG: Luspatercept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Tipranavir/Ritonavir Paediatric Solution Compared to Tipranavir/Ritonavir Capsules in Healthy Female and Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tipranavir oral solution|DRUG: Tipranavir capsules|DRUG: Ritonavir oral solution|DRUG: Ritonavir soft gel capsules|OTHER: High fat breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Approaches to Insulin Therapy in Patients With Type 2 Diabetes (IOOX)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin lispro mid mixture (MM)|DRUG: Insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Soluble Dexamethasone in Refractory Sciatica
Status: COMPLETED
Conditions: Sciatica
Interventions: DRUG: Dexamethasone phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Hypertension Remote Monitoring Evaluation Redesign
Status: ENROLLING_BY_INVITATION
Conditions: Hypertension
Interventions: BEHAVIORAL: Standard and One-time Training|BEHAVIORAL: Standard and Practice Facilitation|BEHAVIORAL: High-intensity and One-time Training|BEHAVIORAL: High-intensity and Practice Facilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Radiation Therapy in Treating Patients With Germ Cell Tumors in the Brain
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: carboplatin|DRUG: cisplatin|DRUG: etoposide phosphate|DRUG: ifosfamide|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: TREC-Lebanon: A Trial for Rapid Tranquilisation for Agitated Patients in the Emergency Setting
Status: COMPLETED
Conditions: Psychiatric Emergency|Aggression|Agitation
Interventions: DRUG: Haloperidol + Promethazine + Chlorpromazine|DRUG: Haloperidol + Promethazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Zimura in Participants With Geographic Atrophy Secondary to Dry Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Geographic Atrophy|Macular Degeneration
Interventions: DRUG: Zimura|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Kegel Exercise and Ba Duan Jin Applications on Premenopausal Women With Urinary Incontinence
Status: RECRUITING
Conditions: Urinary Incontinence|Menopause|Wolman Disease|Quality of Life|Psychological Well-Being
Interventions: BEHAVIORAL: Training on Kegel exercise and Ba Duan Jin applications online|BEHAVIORAL: training on Kegel exercises and Ba Duan Jin applications after the research is completed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dose Exploration Intramuscular/Intravenous Prophylaxis Pharmacokinetic Exposure Response Study
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: AZD3152|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of Fluvastatin and Fenofibrate in Comparison to Simvastatin and Ezetimibe in Patients With Metabolic Syndrome
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: Fluvastatin extended release, fenofibrate|DRUG: Fixed combination simvastatin/ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gait and Balance Impairment in Rare and Very Rare Neurological Diseases
Status: RECRUITING
Conditions: Multiple Sclerosis|Parkinson Disease|Peripheral Neuropathy|Rare Diseases|Healthy|Healthy Aging
Interventions: OTHER: Questionnaires, clinical scales and instrumental tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Comparing CT Scan and Stress Test in Diagnosing Coronary Artery Disease in Patients Hospitalized for Chest Pain
Status: COMPLETED
Conditions: Coronary Artery Disease|Angina Pectoris|Unstable Angina|Acute Coronary Syndrome
Interventions: PROCEDURE: Coronary Computed Tomography Angiography|PROCEDURE: Stress Nuclear Myocardial Perfusion Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: CD19 CAR T Cells for B Cell Malignancies After Allogeneic Transplant
Status: COMPLETED
Conditions: Philadelphia Chromosome Negative Adult Precursor Acute Lymphoblastic Leukemia|Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Mantle Cell Lymphoma|Refractory Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: allogeneic cytomegalovirus-specific cytotoxic T lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification
Status: ACTIVE_NOT_RECRUITING
Conditions: Mitral Regurgitation|Mitral Insufficiency|Mitral Annular Calcification|Mitral Annulus Calcification|Cardiovascular Diseases|Valve Heart Disease|Heart Valve Diseases|Heart Valve Calcification|Mitral Valve Disease
Interventions: DEVICE: Tendyne Mitral Valve System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of Camera Based Gait Quality Measure for Persons With Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis|Multiple Sclerosis, Secondary Progressive|Multiple Sclerosis Relapse|Multiple Sclerosis, Relapsing-Remitting
Interventions: DIAGNOSTIC_TEST: Camera Based Kinematic Analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Remineralization of Dentine Caries Using Two Remineralizing Agents Which Are Nanosilver Fluoride and Casein phosphopeptides_amorphous Calcium Phosphate
Status: UNKNOWN
Conditions: Dental Caries
Interventions: OTHER: Nanosilver fluoride|OTHER: Sodium fluoride with casein phosphopeptides amorphous calcium phosphate|OTHER: Sodium fluoride varnish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sibling Donor Peripheral Stem Cell Transplant or Sibling Donor Bone Marrow Transplant in Treating Patients With Hematologic Cancers or Other Diseases
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Lymphoma|Myelodysplastic Syndromes|Secondary Myelofibrosis
Interventions: BIOLOGICAL: filgrastim|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effects of Exogenous Ketosis on Renal Function, Renal Perfusion, and Sodium Excretory Capacity in Healthy Subjects
Status: COMPLETED
Conditions: Ketosis|Ketonemia
Interventions: DIETARY_SUPPLEMENT: Beta-hydroxybutyrate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy, Safety, and Performance Study of a Novel Device Designed to Manage Fecal Incontinence in Hospitalized Bedridden Patients With Liquid to Semi-formed Stool.
Status: WITHDRAWN
Conditions: Fecal Incontinence
Interventions: DEVICE: Consure 120 Stool Management System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Daily Chlorhexidine Care at the Exit Site in Peritoneal Dialysis Patients
Status: COMPLETED
Conditions: Peritoneal Dialysis Catheter Exit Site Infection
Interventions: DRUG: Chlorhexidine gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Abbreviated MgSO4 Therapy in Post-partum Preeclampsia
Status: COMPLETED
Conditions: Pregnancy|Preeclampsia
Interventions: DRUG: abbreviation of magnesium sulfate therapy (12 hours versus the traditional 24 hours after delivery)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gonadotropin-Releasing Hormone (GnRH)-Antagonist Therapy in Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Cetrorelix|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Partial Tear of Supraspinatus (SSP) and Treatment With Plasma Rich in Growth Factors (PRGF)
Status: WITHDRAWN
Conditions: Partial Supraspinatus Tear
Interventions: BIOLOGICAL: PRGF|OTHER: NACL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intraoperative Sedation on PND in Elderly Patients
Status: UNKNOWN
Conditions: Elderly|Anesthesia
Interventions: DRUG: Patients received lighter sedation with propofol after spinal anesthesia.|DRUG: Patients received heavier sedation with propofol after spinal anesthesia|DRUG: Patients received lighter sedation with dexmedetomidine after spinal anesthesia|DRUG: Patients received heavier sedation with dexmedetomidine after spinal anesthesia.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Excretion Balance and Pharmacokinetics of [14C]-Sodium Valproate (3.7 MBq) in Healthy Postmenopausal or Permanently Sterile Female Subjects
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: sodium valproate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Sodium Bicarbonate (Nephrotrans®) on Calcification Propensity of Serum in Kidney Transplant Recipients
Status: WITHDRAWN
Conditions: Kidney Transplant; Complications
Interventions: DRUG: Low dose sodium bicarbonate|DRUG: High dose sodium bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Pharmacokinetics, Safety, and Tolerability of Abacavir/Dolutegravir/Lamivudine Dispersible and Immediate Release Tablets in HIV-1-Infected Children Less Than 12 Years of Age
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Abacavir (ABC)/Dolutegravir (DTG)/Lamivudine (3TC) Dispersible Tablets|DRUG: Abacavir (ABC)/Dolutegravir (DTG)/Lamivudine (3TC) Immediate Release Tablets (Immediate release)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Hypothermia During Partial Nephrectomy
Status: UNKNOWN
Conditions: Renal Impairment|Kidney Diseases|Urologic Diseases|Cancer|Hypothermia|Kidney Cancer
Interventions: PROCEDURE: Renal hypothermia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion
Status: RECRUITING
Conditions: Stroke|Patent Foramen Ovale
Interventions: DEVICE: Investigational PFO Closure Device|DEVICE: Standard of Care PFO Closure Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of Metformin
Status: COMPLETED
Conditions: Pharmacokinetics of Isavuconazole|Pharmacokinetics of Metformin|Healthy Subjects
Interventions: DRUG: isavuconazole|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy of Whole Extract of Licorice in Neurological Improvement of Patients After Acute Ischemic Stroke
Status: COMPLETED
Conditions: Acute Stroke
Interventions: DRUG: Licorice whole extract|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Exercise Modality on Abdominal Obesity and Health Risk Factors in Older Men and Women
Status: COMPLETED
Conditions: Abdominal Obesity
Interventions: OTHER: Resistance Exercise (RE)|OTHER: Aerobic Exercise (AE)|OTHER: Resistance and Aerobic Exercise (RAE)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Hypofractionated Radiotherapy for Limited Metastatic NSCLC Harboring Sensitizing EGFR Mutations After First Line TKI Therapy
Status: UNKNOWN
Conditions: Lung Adenocarcinoma|EGFR Positive Non-small Cell Lung Cancer
Interventions: DRUG: EGFR-TKI|RADIATION: Thoracic Hypofractionated Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study on Preservation Versus Excision of Denonvilliers Fascia in L-PANP Surgery
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: PROCEDURE: Preservation of Denonvilliers Fascia during L-PANP surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-finding Study of KHK7791 in Hyperphosphatemia Patients
Status: COMPLETED
Conditions: Hyperphosphatemia
Interventions: DRUG: KHK7791|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers
Status: COMPLETED
Conditions: Infected Corneal Ulcers|Bacterial Keratitis|Corneal Ulcer|Childhood Blindness
Interventions: DRUG: Povidone-Iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Germ Cell Tumors
Status: COMPLETED
Conditions: Extragonadal Germ Cell Tumor|Ovarian Cancer|Testicular Germ Cell Tumor
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: etoposide|DRUG: ifosfamide|DRUG: paclitaxel|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Maximally Tolerated Dose (MTD), Safety and Efficacy of CPI-613® (Devimistat) Plus Hydroxychloroquine in Patients With Relapsed or Refractory Clear Cell Sarcoma of Soft Tissue
Status: COMPLETED
Conditions: Sarcoma, Clear Cell
Interventions: DRUG: CPI-613 + Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Impairment Study of Empagliflozin (BI10773) in Japanese Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: BI10773|DRUG: BI10773|DRUG: BI10773|DRUG: BI10773
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mandibular Furcation III Regeneration (FURC-III-REGEN)
Status: TERMINATED
Conditions: Furcation Defects|Periodontal Diseases
Interventions: DEVICE: Biphasic calcium phosphate (Straumann Bone Ceramic) + collagen membrane (Straumann Jason Membrane)|DRUG: Biphasic calcium phosphate (Straumann Bone Ceramic) + enamel matrix proteins (Straumann Emdogain)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Unified Barlow Protocol (UP) in Cancer Survivors for Cognitive Impairments
Status: RECRUITING
Conditions: Cancer, Breast
Interventions: BEHAVIORAL: Neuropsychological treatment|BEHAVIORAL: Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (PU).|BEHAVIORAL: Waitlist group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of the Postoperative Adjuvant Treatment in Patients With High-risk Stage I Endometrial Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Neoplasms
Interventions: DRUG: Paclitaxel|DRUG: Paraplatin (Carboplatin Injection)|RADIATION: Pelvic Radiation|RADIATION: Vaginal Brachytherapy 1|RADIATION: Vaginal brachytherapy 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effects of Traditional Chinese Medicine, Shen-Mai San in Cancer Patient Undergoing Chemotherapy or Radiotherapy
Status: UNKNOWN
Conditions: Cancer Patients Undergoing Chemotherapy or Radiotherapy
Interventions: DRUG: Shen-Mai San|DRUG: Starch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of huMAb OX40L in the Prevention of Allergen-Induced Airway Obstruction in Adults With Mild Allergic Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: huMAb OX40L|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of LEO 29102 Cream in Atopic Dermatitis.
Status: TERMINATED
Conditions: Atopic Dermatitis
Interventions: DRUG: LEO 29102|DRUG: LEO 29102 Cream Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Lower Extremity Operations
Status: COMPLETED
Conditions: Arthroplasty, Replacement
Interventions: DRUG: Dexmedetomidine|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Z-360 Plus GEM in Subjects With Metastatic Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: Z-360|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ambulatory ICU Study for Medically and Socially Complex Patients
Status: COMPLETED
Conditions: Health Services|Comorbidity|Primary Health Care
Interventions: OTHER: SUMMIT intervention|OTHER: Enhanced usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of a Smartphone Intervention to Reduce Sedentary Behavior
Status: WITHDRAWN
Conditions: Risk Reduction Behavior
Interventions: DEVICE: Smartphone with prompts|DEVICE: Wristband|DEVICE: Smartphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Dose Titration of Droxidopa in Patients With Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury|Hypotension
Interventions: DRUG: Droxidopa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of rTMS With Double-Cone-Coil in Patients With Major Depression
Status: COMPLETED
Conditions: Depression
Interventions: DEVICE: Medial Frontal rTMS Double-Cone-Coil|DEVICE: Left DLPFC Butterfly Coil|DEVICE: Placebo Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Administration of GnRH Antagonist to Oocyte Donation Recipients
Status: COMPLETED
Conditions: Pregnancy|Embryo Implantation
Interventions: DRUG: triptorelin (Decapeptyl®, Ipsen Pharma, Barcelona, Spain)|DRUG: GnRH antagonist (Orgalutran®)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Biodex Balance Training Versus Whole Body Vibration Training in Patients With Knee Osteoarthritis
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Biodex Balance Training|DEVICE: A vibration device|OTHER: traditional exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Anticholinergic Premedication for Sedation With Dexmedetomidine During Spinal Anesthesia
Status: COMPLETED
Conditions: Bradycardia
Interventions: DRUG: Atropine|DRUG: Dexmedetomidine|DRUG: Ephedrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluate Effects of Meropenem-Vaborbactam on QT/QTc in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: meropenem-vaborbactam|DRUG: Placebo|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Ex-vivo Primed Memory Donor Lymphocyte Infusion to Boost Anti-viral Immunity After T-cell Depleted HSCT
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia|High Risk Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia, in Relapse|High Risk Acute Lymphoblastic Leukemia|Acute Biphenotypic Leukemia in Relapse|Non-hodgkin Lymphoma|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: boost anti-viral immunity after T-cell depleted HSCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Clinical Music Improvisation on Resiliency in Adults Undergoing Infusion Therapy
Status: COMPLETED
Conditions: Anxiety
Interventions: OTHER: Clinical Improvisation Instrumental Music Therapy|OTHER: Clinical Vocal Improvisation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Timing for Bone Marrow Mononuclear Cells After Acute Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: OTHER: BMC therapy within 24 hours|OTHER: BMC therapy within 3-7 days|OTHER: BMC therapy within 7-30 days|OTHER: PCI only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DetectFoG : Detection of Gait Freezing Episodes in Parkinsonian Patients Using Inertial Measurement Units
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: OTHER: Walk under 3 conditions (normal, physical tasks, verbal tasks)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Role of Probiotics in Improving Quality of Life in Women With Functional Constipation
Status: COMPLETED
Conditions: Constipation - Functional
Interventions: DRUG: Lactobacillus plantarum IS-10506|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Quadriceps Exercise Before Total Knee Arthroplasty (The QUADX-1 Trial)
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: OTHER: Two knee-extension exercise sessions per week.|OTHER: Four knee-extension exercise sessions per week.|OTHER: Six knee-extension exercise sessions per week.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the PK , Safety, Tolerability, and Immunogenicity of HLX15 With Daratumumab in Male Subjects
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: HLX15|DRUG: US-sourced DARZALEX®|DRUG: CN-sourced DARZALEX®|DRUG: EU-sourced DARZALEX®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety & Feasibility of DSR TherApy in Heart FAiluRe pAtients With Persistent Congestion
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure|Volume Overload
Interventions: DEVICE: ALFAPUMP DSR (DIRECT SODIUM REMOVAL) SYSTEM|DRUG: SGLT2 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: NAUTILUS CE-mark Trial of the FLOWer Cerebral Embolic Protection Device
Status: COMPLETED
Conditions: Aortic Valve Stenosis|Intracranial Embolism and Thrombosis
Interventions: PROCEDURE: TAVI (Transcatheter Aortic Valve Implant)|DEVICE: FLOWer Embolic Protection System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: "Treatment of Active HBV With γδT Cells" Clinical Trial Protocol
Status: UNKNOWN
Conditions: Adoptive Treatment for Hepatitis B With γδT Cells
Interventions: COMBINATION_PRODUCT: Adoptive transfer of γδT cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arsenic Trioxide in Treating Patients With Advanced Cancer of the Esophagus or Gastroesophageal Junction
Status: TERMINATED
Conditions: Adenocarcinoma of the Esophagus|Stage III Esophageal Cancer|Stage IV Esophageal Cancer
Interventions: DRUG: arsenic trioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Caspofungin (Cancidas ®) Given Intravenously as Therapy to Patients With an Invasive Fungal Infection in the Intensive Care Unit - a Search for Co-variates
Status: COMPLETED
Conditions: Invasive Fungal Infection
Interventions: DRUG: caspofungin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Disseminating Evidence-based Mood Disorder Chronic Care Models
Status: COMPLETED
Conditions: Bipolar Disorder|Depression
Interventions: BEHAVIORAL: Chronic Care Model for Mood Disorders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Model of Variability of the Lipid Profile in Pregnant Women and Its Relationship to lactogénesis
Status: UNKNOWN
Conditions: Pregnant Woman With Single Pregnancy|Pregnant Woman With no Assisted Reproduction
Interventions: OTHER: Variability of the lipid profile in pregnant women
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC