pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Combination Chemotherapy Plus Filgrastim in Treating Patients With Stage IV Prostate Cancer That Has Not Responded to Hormone Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: docetaxel|DRUG: estramustine phosphate sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Lower Extremity Intervention With Integrated Embolic Protection Using the Vanguard IEP System
Status: COMPLETED
Conditions: Peripheral Arterial Disease|Intermittent Claudication|Atherosclerosis of Femoral Artery
Interventions: DEVICE: peripheral balloon angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Phase III Study of Sequential Radiochemotherapy of Anaplastic Glioma With PCV or Temozolomide
Status: COMPLETED
Conditions: Anaplastic Astrocytoma|Oligodendroglioma|Oligoastrocytoma
Interventions: DRUG: Temozolomide|RADIATION: Focal radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GPC3 Targeted Fluorescence Image Guided Surgery of Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Anti-GPC3-IRDye800CW
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treatment of Classical Non-HIV-Related Kaposi's Sarcoma With the Antiviral Drug Indinavir
Status: COMPLETED
Conditions: Classical Kaposi's Sarcoma
Interventions: DRUG: indinavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Cannulation of Difficult Hemodialysis Arteriovenous Access
Status: RECRUITING
Conditions: Successful Cannulation
Interventions: DEVICE: asus-handheld-ultrasound LU710L
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Local Tolerability of DFD-03 (Tazarotene) Lotion, 0.1% Compared to Tazorac® Cream, 0.1% in the Topical Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: DFD-03 Lotion, 0.1%|DRUG: Tazorac Cream, 0.1%|DRUG: DFD-03 Vehicle Lotion 0%|DRUG: Tazorac Vehicle Cream 0%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of RTB101 as COVID-19 Post-Exposure Prophylaxis in Older Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Covid19
Interventions: DRUG: RTB101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intraoperative Ansa Cervicalis Nerve (ACN) Stimulation
Status: RECRUITING
Conditions: Head and Neck Cancer|Obstructive Sleep Apnea
Interventions: DEVICE: Nerve stimulation using nerve stimulation device and sterile wire electrode.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Endostar Combined With Concurrent Chemoradiotherapy for Locoregionally Advanced Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Endostar|DRUG: DDP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nicotinamide Mononucleotide in Hypertensive Patients
Status: UNKNOWN
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: Nicotinamide mononucleotide supplied as 400mg capsule|BEHAVIORAL: Lifestyle modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Versus Late Post Caesarean Section Oral Anticoagulation Initiation and Risk of Maternal Complications in Patients With Mechanical Heart Valve Prosthesis
Status: UNKNOWN
Conditions: Maternal Complications After Oral Anticoagulation When Initiated Early and Late After Caesarean Section Done for Patients With Mechanical Heart Valve Prosthesis
Interventions: DRUG: Warfarin Sodium started on Day 2 after caesarean section (in a dose that achieves a therapeutic level as indicated by the cardiology consultant)|DRUG: Warfarin Sodium started on day 5 after caesarean section (in a dose that achieves a therapeutic level as indicated by the cardiology consultant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lactobacillus Reuteri ATCC PTA 4659 in Ulcerative Colitis
Status: UNKNOWN
Conditions: Ulcerative Colitis Flare
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Aminolevulinic Acid to Enhance Visualization and Resection of Malignant Glial Tumors of the Brain
Status: COMPLETED
Conditions: Brain Tumors
Interventions: DRUG: Aminolevulinic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pregabalin in the Treatment of Patients With Generalized Anxiety Disorder (GAD).
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: DRUG: pregabalin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of Blow Bottle and Acapella Along With Diaphragmatic Breathing in Patients With Pneumonia
Status: RECRUITING
Conditions: Pneumonia
Interventions: OTHER: Blow Bottle technique|OTHER: Acapella along with Diaphragmatic Breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment
Status: COMPLETED
Conditions: Extragonadal Germ Cell Tumor|Ovarian Cancer|Teratoma|Testicular Germ Cell Tumor
Interventions: DRUG: sunitinib malate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Cholecystectomy: General Anesthesia With Opioid Versus General Opioid Free Anesthesia
Status: UNKNOWN
Conditions: Pain, Postoperative|Anesthesia Complication|Nausea|Vomiting|Ileus Paralytic|Hemodynamic Instability
Interventions: DRUG: dexter ketamine|DRUG: Lidocaine Hydrochloride|DRUG: Fentanyl Hydrochloride|DRUG: Clonidine Hydrochloride|DRUG: Midazolam Hydrochloride|DRUG: Isoflurane Volatile Liquid|DRUG: Rocuronium Injectable Solution|DRUG: Propofol 1 % Injectable Suspension|DRUG: Dexamethasone-21-Sulfobenzoate, Sodium Salt|DRUG: Ranitidine Hydrochloride|DRUG: Ondansetron Hydrochloride|DRUG: Ketorolac Injectable Solution|DRUG: Bupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Optimization of Fractionation Schedules of Heel Spur Radiotherapy Prospective Randomized Open-label Trial
Status: RECRUITING
Conditions: Heel Spur
Interventions: RADIATION: Standard fractioned dose|RADIATION: Experimental single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selumetinib and Azacitidine in High Risk Chronic Blood Cancers
Status: RECRUITING
Conditions: Chronic Myeloid Leukemia|Myelofibroses
Interventions: DRUG: Azacitidine|DRUG: Selumetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platform Trial of Novel Regimens Versus Standard of Care (SoC) in Participants With Non-small Cell Lung Cancer (NSCLC)
Status: RECRUITING
Conditions: Neoplasms
Interventions: DRUG: Docetaxel|DRUG: Feladilimab|DRUG: Ipilimumab|DRUG: GSK4428859A|DRUG: Dostarlimab|DRUG: GSK6097608
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methotrexate and Etoposide Infusions Into the Fourth Ventricle in Children With Recurrent Posterior Fossa Brain Tumors
Status: RECRUITING
Conditions: Brain Tumor Recurrent
Interventions: DRUG: Methotrexate|DRUG: Etoposide|PROCEDURE: Ommaya Reservoir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Random Control Study :Early Use of Airway Pressure Release Ventilation (APRVplus) Protocol in ARDS
Status: RECRUITING
Conditions: Acute Respiratory Distress Syndrome
Interventions: PROCEDURE: APRVplus protocol|PROCEDURE: Low tidal volume ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Bovine Colostrum in Bone Metabolism in Humans
Status: COMPLETED
Conditions: Osteopenia|Osteoporosis
Interventions: DIETARY_SUPPLEMENT: Colostrum supplementation for bone loss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Cannabis Use and Cognitive Outcomes in Schizophrenia
Status: COMPLETED
Conditions: Repetitive Transcranial Magnetic Stimulation (rTMS)|Schizophrenia|Cannabis Use Disorder|Cognition
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)|DEVICE: Sham Repetitive Transcranial Magnetic Stimulation (rTMS)|BEHAVIORAL: Weekly Counselling Session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Preference Study of Pazopanib Versus Sunitinib in Advanced or Metastatic Kidney Cancer
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: pazopanib|DRUG: sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of 8-week Dietary Intake of Novel Food Supplement on Minimal Erythema Dose
Status: RECRUITING
Conditions: Minimal Erythema Dose
Interventions: DIETARY_SUPPLEMENT: Active product|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Toxicokinetic Study of Dichlorobisphenol A After an Oral or Dermal Single Dose in Healthy Volunteer.
Status: UNKNOWN
Conditions: Pharmacokinetic Study
Interventions: OTHER: Administration of d12-Cl2BPA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Early Enteral Tube Feeding Nutrition With an Immune Enhancing Diet in Severe Burn Patients
Status: COMPLETED
Conditions: Infections on|Severe Burn Patients
Interventions: DIETARY_SUPPLEMENT: Crucial|DIETARY_SUPPLEMENT: Sondalis HP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cabozantinib With Ifosfamide in Ewing's Sarcoma and Osteosarcoma
Status: RECRUITING
Conditions: Ewing Sarcoma|Osteosarcoma
Interventions: DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Examining Doses of Abiraterone Acetate in Adult Women With 21-Hydroxylase Deficiency
Status: COMPLETED
Conditions: 21-hydroxylase Deficiency
Interventions: DRUG: Abiraterone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed and Carboplatin in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
Status: COMPLETED
Conditions: Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma
Interventions: DRUG: Carboplatin|OTHER: Laboratory Biomarker Analysis|DRUG: Pemetrexed Disodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GV1001 Subcutaneous(SC) for the Treatment of Mild to Moderate Alzheimer's Disease (AD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild to Moderate Alzheimer's Disease
Interventions: DRUG: GV1001 Placebo|DRUG: GV1001 0.56mg|DRUG: GV1001 1.12mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: R21: An Easy-to-use, iNtelligent, Affordable LinEr (ENABLE) System for Socket Fit Assessment
Status: RECRUITING
Conditions: Lower Limb Amputation Below Knee (Injury)
Interventions: DEVICE: Apply ENABLE sensing pad|DEVICE: Insert small pads at pressure tolerant locations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Breast Stimulation vs. Low Dose Oxytocin Augmentation for Labor Induction
Status: NOT_YET_RECRUITING
Conditions: Labor Onset and Length Abnormalities|Uterine Rupture|Birth; Induced
Interventions: PROCEDURE: Breast stimulation|BIOLOGICAL: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Gemzar, Taxotere, and Xeloda for Adjuvant Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Docetaxel|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Muscles Energy Technique in the Management of Chronic Non-specific Low Back Pain
Status: COMPLETED
Conditions: Chronic Non-specific Low Back Pain
Interventions: PROCEDURE: DSE plus MET group A|PROCEDURE: DSE alone group B|PROCEDURE: Standard Physiotherapy treatment group C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alcohol Pharmacotherapy for HIV+ Prisoners
Status: COMPLETED
Conditions: Alcohol Dependence|Problem Drinking|Hazardous Drinking|Human Immunodeficiency Virus|AIDS
Interventions: DRUG: Vivitrol- Intramuscular naltrexone (depot-formulation)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Response to Albuterol Delivered Through an Anti-static Valved Holding Chamber During Nocturnal Bronchospasm
Status: COMPLETED
Conditions: Asthma
Interventions: DEVICE: anti-static then static|DEVICE: Static then anti-static chamber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Suture Material in Closure of Uterine Incision in Cesarian Section
Status: COMPLETED
Conditions: Hysterotomy Closure
Interventions: PROCEDURE: Stratafix synthetic barbed suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Reduced Dose Total Body Irradiation (TBI) and Cyclophosphamide With Fludarabine and Melphalan Reduced Intensity Conditioning in Adults With Acute Lymphoblastic Leukaemia (ALL) in Complete Remission. (ALL-RIC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Fludarabine|DRUG: Melphalan|DRUG: Alemtuzumab|DRUG: Cyclophosphamide|DRUG: Mesna|RADIATION: Total Body Irradiation (8Gy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Roxadustat (FG-4592) for the Treatment of Anemia in End-Stage Renal Disease (ESRD) Newly Initiated Dialysis Participants
Status: COMPLETED
Conditions: Anemia in Incident Dialysis Patients
Interventions: DRUG: Roxadustat|DRUG: Epoetin Alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of Amlodipine / Valsartan From Amlodipine/Valsartan 10/160 Tablets (Pharmacare, Palestine) and Exforge Tablets (Novartis Pharma, USA)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Amlodipine/Valsartan|DRUG: Exforge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: An Observational Study to Learn More About Vericiguat Treatment Patterns and Its Safety in People With Chronic Heart Failure With Reduced Ejection Fraction in Routine Medical Care in the United States
Status: COMPLETED
Conditions: Chronic Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: Vericiguat (Verquvo, BAY1021189)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pulsed Radiofrequency and Osteoarthritic Chronic Knee Pain
Status: COMPLETED
Conditions: Pulsed Radiofrequency|Osteoarthritis, Knee|Knee Pain Chronic|Knee Arthritis
Interventions: DEVICE: Pulsed Radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Patiromer on Pharmacokinetics of Immunosuppresive Drugs in Renal Transplant Recipients
Status: COMPLETED
Conditions: Hyperkalemia|Kidney Transplant
Interventions: DRUG: Patiromer Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propranolol in Primary Progressive Aphasia
Status: RECRUITING
Conditions: Aphasia, Primary Progressive
Interventions: DRUG: Propranolol|DEVICE: Magnetic Resonance Imaging (MRI)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Drug to Reduce Thrombocytopenia in Patients Receiving Chemo for Ovarian, Fallopian Tube or Peritoneal Cancer
Status: COMPLETED
Conditions: Thrombocytopenia|Neutropenia|Lymphopenia|Anemia
Interventions: DRUG: TXA127|DRUG: TXA127|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study Evaluating the Safety and Efficacy of LentiRed Drug Product in Transfusion-dependent β-Thalassemia [TDT]
Status: RECRUITING
Conditions: Transfusion Dependent Beta-Thalassemia
Interventions: GENETIC: GMCN-508B (LentiRed)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Trial of ASTX030 in Patients With Myelodysplastic Syndrome
Status: RECRUITING
Conditions: Myelodysplastic Syndrome (MDS)
Interventions: DRUG: ASTX030
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FluSAFE: Flu SMS Alerts to Freeze Exposure
Status: COMPLETED
Conditions: Influenza|Acute Respiratory Infection|Influenza-like Illness
Interventions: BEHAVIORAL: Educational text messages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating Safety, Tolerability, and Potential Efficacy of Intranasal AD17002 in Adults With Mild to Moderate COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: AD17002|BIOLOGICAL: Placebo (Formulation buffer)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SPEECH as Biomarker for Emotion, Movement and cOgnition in Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: OTHER: Dopaminergic OFF drug state|OTHER: DBS OFF state|OTHER: Dopaminergic ON drug state|OTHER: DBS ON state
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Different Doses of Dexmedetomidine Effect in the Duration of Spinal Anesthesia
Status: UNKNOWN
Conditions: Spinal Anesthesia Duration
Interventions: DRUG: intrathecal Dexmedetomidine|DRUG: Dexmedetomidine 1.5 micrograms|DRUG: Dexmedetomidine 3 micrograms|DRUG: Dexmedetomidine 5 micrograms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Precise Transcranial Magnetic Stimulation for Post-traumatic Stress Disorder
Status: RECRUITING
Conditions: PTSD
Interventions: DEVICE: Active transcranial magnetic stimulation|DEVICE: Sham transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Double Blind Placebo COntrolled Dose Ranging studY of the eFficacy and safEty of SSR149744c 300 or 600 mg for the Conversion of Atrial Fibrillation / fluttEr
Status: COMPLETED
Conditions: Atrial Fibrillation|Atrial Flutter
Interventions: DRUG: CELIVARONE (SSR149744C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of B013 in Combination With Paclitaxel in Patients With Platinum-resistant Recurrent Ovarian Cancer.
Status: RECRUITING
Conditions: Platinum-resistant Recurrent Ovarian Cancer
Interventions: DRUG: B013|DRUG: Paclitaxel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Doxapram as an Additive to Propofol Sedation in Sedation for ERCP
Status: COMPLETED
Conditions: Sedation|Hypoxia
Interventions: DRUG: Doxapram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Emibetuzumab in Combination With Ramucirumab (LY3009806) in Participants With Advanced Cancer
Status: COMPLETED
Conditions: Advanced Cancer|Gastric Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma|Hepatocellular Cancer|Renal Cell Carcinoma|Non-Small Cell Lung Cancer
Interventions: DRUG: Emibetuzumab|DRUG: Ramucirumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Umbilical Cord Blood Mononuclear Cell Therapy for the Treatment of Chronic Atrophic Gastritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Atrophic Gastritis
Interventions: BIOLOGICAL: Mononuclear cells|DRUG: Weifuchun+Hydrotalcite/L-Glutamine and Sodium Gualenate Granules
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeting the Right Ventricle in Pulmonary Hypertension
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Ranolazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study To Evaluate The Safety And Tolerability Of Dimebon Patients With Mild To Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Dimebon|DRUG: Placebo|DRUG: Dimebon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Compression of the Lid Margin Increase Microbial Contamination Risk of Patients Undergoing Cataract Surgery
Status: COMPLETED
Conditions: Cataract
Interventions: PROCEDURE: compression and scrub of lid margin|PROCEDURE: routine preparation for cataract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: PREACT Study: Locally Advanced Gastric Cancer, Chemoradiotherapy vs. Chemotherapy Followed by D2 Surgery and Adjuvant Chemotherapy
Status: UNKNOWN
Conditions: Stomach Neoplasm|GastroEsophageal Cancer|Adenocarcinoma|Locally Advanced Cancer|Chemoradiation
Interventions: DRUG: Tegafur-Gimeracil-Oteracil Potassium|RADIATION: Chemoradiotherapy|PROCEDURE: Gastric resection|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Aged Garlic Extract on Atherosclerosis
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DRUG: aged garlic extract|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation for Functional Memory Symptoms After Concussion
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild Traumatic Brain Injury|Functional Neurological Disorder
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy (CBT)|BEHAVIORAL: Cognitive Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Trial of Inhaled Alpha1-Proteinase Inhibitor (Human), Hydrophobic Chromatography Process (Alpha-1 HC) in Subjects With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: BIOLOGICAL: Alpha-1 HC 100 mg|BIOLOGICAL: Placebo|BIOLOGICAL: Alpha-1 HC 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gabapentin for Sleep in Critically Ill Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Intensive Care Unit Sleep Disruption
Interventions: DRUG: Gabapentin 300 mg PO at 8 PM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Supplemental Corticosteroids in Cirrhotic Hypotensive Patients With Suspicion of Sepsis
Status: TERMINATED
Conditions: Liver Cirrhosis
Interventions: DRUG: Hydrocortisone|DRUG: NaCL 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cannabis for Inflammatory Bowel Disease
Status: UNKNOWN
Conditions: Crohn's Disease|Ulcerative Colitis
Interventions: DRUG: smoking of cannabis|DRUG: smoking cigarettes with placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Obstructive Sleep Apnea and Acute Myocardial Infarction and the Role of Continuous Positive Airway Pressure (CPAP)Treatment
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive|Acute Myocardial Infarction
Interventions: DEVICE: Sham CPAP|DEVICE: CPAP of optimal pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Standard Versus Advanced Antimicrobial Dressing Containing Ionic Silver Following Colorectal Cancer Surgery
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DEVICE: AQUAGEL Ag Hydrofiber Wound Dressing|DEVICE: Mepore Self-adhesive absorbent dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Letrozole and Palbociclib in Patients With Stage II-IIIB Breast Cancer, HR+, HER2 -
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Pre treatment Recurrence Score:18-25 Letrozole + Palbociclib|DRUG: Pre treatment Recurrence Score:26-100 Letrozole + Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aczone 5% Gel as Maintenance Treatment of Acne Vulgaris Following Completion of Oral Doxycycline and Aczone 5% Gel
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Doxycycline 100mg|DRUG: Aczone 5% gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Summers Non-Pesticide Lice Asphyxiator (L.A.)for the Treatment of Head Lice
Status: COMPLETED
Conditions: Head Lice
Interventions: DRUG: Summers 5% L.A.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Convergent Ablation Plus Left Atrial Appendage Isolation for the Treatment of Persistent Atrial Fibrillation
Status: RECRUITING
Conditions: Persistent Atrial Fibrillation|Atrial Fibrillation, Persistent|Atrium; Fibrillation|Atrial Arrhythmia
Interventions: DEVICE: Epicardial AF ablation using AtriCure EPi-Sense-AF Guided Coagulation System with Left Atrial Appendage Exclusion using the AtriCure LARIAT Suture Delivery Device.|PROCEDURE: Standard Endocardial Catheter Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Norwegian Food Based Dietary Guidelines on Chronic Diseases in CRC Survivors
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer
Interventions: OTHER: Norwegian food based dietary guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Accuracy Testing of the Chromosomal Aberration and Gene Mutation Markers of the AMLProfiler
Status: TERMINATED
Conditions: Acute Myeloid Leukemia (AML)|Acute Promyelocytic Leukemia (APL)|Refractory Anemia With Excess of Blasts (RAEB)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Lenses in Abolishing Photoparoxysmal Responses
Status: ACTIVE_NOT_RECRUITING
Conditions: Reflex Epilepsy, Photosensitive|Eyeglasses
Interventions: DEVICE: Z1 lens|DEVICE: Experimental Lens 1|DEVICE: Experimental Lens 2|DEVICE: Experimental Lens 3|DEVICE: Experimental Lens 4
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adopting and Demonstrating the Adaptation of Prevention Techniques (ADAPT), Harlem United Community AIDS Center
Status: COMPLETED
Conditions: Sexually Transmitted Diseases|HIV Infections
Interventions: BEHAVIORAL: Healthy Relationships
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CLinical Evaluation of ANtiseptic Skin Preparation in Revision Total Joint Arthroplasty of the Hip and Knee
Status: RECRUITING
Conditions: Aseptic Revision Total Hip Arthroplasty|Total Knee Arthroplasty With Exchange of at Least One Prosthetic Component
Interventions: DRUG: surgical antiseptic skin preparation with either chlorhexidine or iodine-based solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Radiation Dosimetry, Metabolism, Pharmacokinetics, Safety and Tolerability and PET Imaging With BAY94-9392 in Healthy Volunteers and Patients With Cancer or Inflammation
Status: COMPLETED
Conditions: Diagnostic Imaging|Neoplasms
Interventions: DRUG: BAY94-9392
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Investigating Effects in Intestinal Permeability of Rich in Beta-glucans Pleurotus Eryngii Mushrooms Fermentation Supernatants: an Ex-vivo Study
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Fermented product of Pleurotus eryngii mushroom
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prevention of Preterm Birth Using Cervical Pessary in Pregnant Women With Short Cervix in Twins
Status: COMPLETED
Conditions: Preterm Birth
Interventions: DEVICE: Silicon ring (Arabin Cervical Pessary)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Leptospermum Scoparium Honey and Wound Care for Pressure Ulcers
Status: WITHDRAWN
Conditions: Pressure Ulcers
Interventions: OTHER: Leptospermum scoparium honey|OTHER: Standard of Care Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Impact of Peripheral Afferent Input on Central Neuropathic Pain
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injuries|Spinal Cord Diseases|Syringomyelia
Interventions: DIAGNOSTIC_TEST: Lidocaine (10 mg/ml)|DIAGNOSTIC_TEST: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Ketamine On Depressive Symptoms In Patients Undergoing Lumbo-peritoneal Shunt Insertion
Status: RECRUITING
Conditions: Depression, Anxiety
Interventions: DRUG: normal Saline|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Food Related Video and the Incidence of Postoperative Nausea and Vomiting
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: OTHER: Visual exposure to taped food preparation|OTHER: Visual exposure to topics not related to food
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Combined RHUMAB VEGF and Capecitabine-based Chemoradiation for Patients With Locally Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Bevacizumab|DRUG: Capecitabine|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VITAL Rhythm Study
Status: UNKNOWN
Conditions: Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DRUG: Omega-3 fatty acids (fish oil)|DIETARY_SUPPLEMENT: Fish oil placebo|DIETARY_SUPPLEMENT: Vitamin D3 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multicenter Clinical Trial on the Effectiveness and Safety of Instillation of BCG and Alternative BCG Protocols for Intermediate and High-risk Non-muscle Invasive Bladder Cancer
Status: RECRUITING
Conditions: Urinary Bladder Neoplasms|BCG Vaccine|Immunotherapy, Active|Multicenter Study|Treatment Outcome|Neoplasm Recurrence, Local
Interventions: DRUG: Tislelizumab in Combination with Bacillus Calmette-Guérin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of MK-7622 as Adjunct Therapy in Participants With Alzheimer's Disease (MK-7622-012)
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: MK-7622|DRUG: Placebo|DRUG: AChEI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improved Hemodynamic Tolerance of Intermittent Hemodialysis Sessions in Intensive Care Unite Using Citrate- vs Acetate-based Dialysate
Status: RECRUITING
Conditions: Intradialytic Hypotension
Interventions: DEVICE: ACETATE based dialysate|DEVICE: CITRATE based dialysate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase III Clinical Trial of a 11-valent Recombinant Human Papillomavirus Vaccine (Hansenulapolymorpha) in Chinese Women Aged 9-45 Years
Status: RECRUITING
Conditions: HPV InfectioN|HPV-Related Carcinoma
Interventions: BIOLOGICAL: 11-valent recombinant human papilloma virus vaccine (Hansenula polymorpha)|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinician-Supported PTSD Coach vs. Self-Managed PTSD Coach
Status: COMPLETED
Conditions: PTSD
Interventions: BEHAVIORAL: Clinician-Supported PTSD Coach|BEHAVIORAL: Self-Managed PTSD Coach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SBRT With Combination Ipilimumab/Nivolumab for Metastatic Kidney Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: Ipilimumab/ Nivolumab|RADIATION: SBRT + Ipilimumab/Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Genistein in Women With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: genistein|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Safety and PK of SYN060 to Humira® in Healthy Adult Subjects
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: BIOLOGICAL: SYN060|BIOLOGICAL: Adalimumab North American source|BIOLOGICAL: Adalimumab European source
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Post Tonsillectomy Ibuprofen Use in Adults
Status: UNKNOWN
Conditions: Secondary Post Tonsillectomy Hemorrhage|Primary Post Tonsillectomy Hemorrhage
Interventions: DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: High-level Laser for Provoked Vestibulodynia
Status: COMPLETED
Conditions: Vulvodynia
Interventions: RADIATION: High-level laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modafinil Treatment for Sleep/Wake Disturbances in Older Adults
Status: TERMINATED
Conditions: Insomnia|Sleep Initiation and Maintenance Disorders|Alzheimer Disease
Interventions: DRUG: modafinil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectivity of Laparoscopic Inguinal Hernia Repair (TAPP) in Daily Clinical Practice - Early and Long-term Results
Status: COMPLETED
Conditions: Unilateral Inguinal Hernia With Gangrene and Obstruction
Interventions: DEVICE: Laparoscopic hernia repair
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal Polyps
Status: RECRUITING
Conditions: Sinusitis|Nasal Polyps
Interventions: PROCEDURE: Endoscopic polypectomy in clinic (EPIC)|PROCEDURE: Endoscopic Sinus Surgery (ESS)|OTHER: General Anesthesia|OTHER: Local and topical anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of AOT Based on Virtual Reality in Stroke Rehabilitation.
Status: ACTIVE_NOT_RECRUITING
Conditions: Stroke|Hemiplegia|Hemiparesis
Interventions: BEHAVIORAL: AO+VR|BEHAVIORAL: CO+VR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cultural Pride Reinforcement for Early School Readiness Study
Status: NOT_YET_RECRUITING
Conditions: Child Behavior|Child Behavior Problem|Child Behavior Disorders|Racism
Interventions: BEHAVIORAL: Cultural Pride Reinforcement for Early School Readiness|BEHAVIORAL: Reach Out and Read
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Everolimus With Enteric-Coated Mycophenolate Sodium (EC-MPS) in a Cyclosporine Microemulsion-free Regimen Compared to Standard Therapy in de Novo Renal Transplant Patients
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: Everolimus|DRUG: Cyclosporine|DRUG: Enteric-coated mycophenolate sodium|DRUG: Corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Vitrase for Clearance of Severe Vitreous Hemorrhage
Status: COMPLETED
Conditions: Vitreous Hemorrhage|Diabetic Retinopathy
Interventions: DRUG: Vitrase|DRUG: Vitrase|DRUG: Vitrase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 177Lu-DOTA-EB-TATE in Adult Patients With Advanced, Well- Differentiated Neuroendocrine Tumors
Status: RECRUITING
Conditions: Neuroendocrine Tumors
Interventions: DRUG: 177Lu-DOTA-EB-TATE|OTHER: Amino Acid Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of the Paradigm 722 System to Improve Glycemic Control in Adult and Adolescent Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: Paradigm 722 sensor augmented pump|DEVICE: Paradigm 715 insulin pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability Study of ND0612 vs. Oral Immediate Release Levodopa/Carbidopa (IR-LD/CD) in Subjects With Parkinson's Disease Experiencing Motor Fluctuations
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson's Disease
Interventions: COMBINATION_PRODUCT: ND0612 Solution for SC infusion|COMBINATION_PRODUCT: Placebo for SC infusion|DRUG: Oral IR-LD/CD|DRUG: Placebo for Oral IR-LD/CD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Bevacizumab Followed by Steroid in RN
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma|Adverse Effect of Radiation Therapy|Brain Injuries
Interventions: DRUG: Bevacizumab and steroid|DRUG: Bevacizumab and placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficiency of Intermittent Enteral Nutrition on Multi-organ Failure From Patients With Mechanical Ventilation in Intensive Care Unit
Status: NOT_YET_RECRUITING
Conditions: Intermittent Fasting|Septic Shock|Organ Failure, Multiple
Interventions: OTHER: Intermittent enteral nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Modified Perineal Linear Stapler Resection for External Rectal Prolapse: a Novel Approach
Status: COMPLETED
Conditions: Rectal Prolapse
Interventions: OTHER: Modified perineal linear stapler resection for external rectal prolapse
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of CureXcell® in Treating Chronic Venous Leg Ulcers
Status: UNKNOWN
Conditions: Chronic Venous Leg Ulcers
Interventions: BIOLOGICAL: CureXcell®|OTHER: Placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EXCELLENT (EXpanded CELL ENdocardiac Transplantation)
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: PROTHERACYTES|DRUG: Standard Treatment for CHF post AMI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Parecoxib on the Change of Shoulder Pain Threshold After Gynecological Laparoscopies
Status: COMPLETED
Conditions: Postoperative Pain Management, Pain Threshold, Shoulder Pain, Laparoscopies
Interventions: DRUG: Parecoxib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION