pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Allo-Allo Tandem Bone Marrow Transplant (BMT)
Status: UNKNOWN
Conditions: Refractory Acute Leukemia
Interventions: PROCEDURE: Allogeneic hematopoietic stem-cell-transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studying Newborns' Brain Activity in the NICU Through a Musical Intervention: the Role of Fundamental Frequency
Status: RECRUITING
Conditions: Premature Birth
Interventions: OTHER: Music Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Quality Measurement and Improvement Study of Surgical Coronary Revascularization: Secondary Prevention
Status: COMPLETED
Conditions: Coronary Artery Bypass Grafting|Secondary Preventions
Interventions: BEHAVIORAL: Quality improvement strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Long-term Study of ADVM-022 in Neovascular (Wet) AMD [OPTIC-EXT]
Status: ACTIVE_NOT_RECRUITING
Conditions: Wet Age-related Macular Degeneration|Neovascular Age-related Macular Degeneration
Interventions: BIOLOGICAL: ADVM-022
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Acceptability & Tolerance of Immediate Versus Delayed Postpartum Contraceptive Implant
Status: COMPLETED
Conditions: Breastfeeding|Post Partum
Interventions: DRUG: Etonogestrel Drug Implant|DRUG: Levonorgestrel Drug Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Cephalaria Syriaca Flour-added Bread on Glucose Metabolism and Appetite Parameters in Individuals With Obesity, Diabetes, and Healthy Controls.
Status: COMPLETED
Conditions: Nutrition, Healthy
Interventions: DIETARY_SUPPLEMENT: Cephalaria Syriaca flour-added bread
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigation of the Changes of Brain Structure and Function in Premature Ejaculation Patients and the Effects of Dapoxetine on Central Neural Activity in Premature Ejaculation Patients
Status: UNKNOWN
Conditions: Premature Ejaculation
Interventions: DRUG: Dapoxetine Hydrochloride Tablet|DRUG: Placebo Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: INF108F in Infants With Food Protein Induced Proctocolitis
Status: RECRUITING
Conditions: Infant Development|Gut Microbiome|Food Protein Induced Allergic Proctocolitis
Interventions: DRUG: INF108F probiotic|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Project ASTHMA - Aligning With Schools To Help Manage Asthma and Decrease Health Inequities
Status: NOT_YET_RECRUITING
Conditions: Asthma in Children|Directly Observed Therapy
Interventions: OTHER: APP assessment and management of asthma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Long Term Administration of Inhaled Mannitol in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: inhaled mannitol|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carfilzomib Based Chemotherapy Mobilization for Autologous Stem Cell Transplants in Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Carfilzomib|DRUG: Cyclophosphamide|DRUG: Dexamethasone|DRUG: Granulocyte Colony-Stimulating Factor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Morphine for Cesarean Delivery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Morphine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) in Adults With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Treatment-naïve Nonsmall Cell Lung Cancer (NSCLC) [MK-7902-007/E7080-G000-314/LEAP-007] - China Extension Study
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Lenvatinib|DRUG: Placebo for lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Optimal PEEP Determination Guided by EIT and G5 Device in Moderate and Severe ARDS Patients
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome
Interventions: DEVICE: optimal PEEP guided by EIT|DEVICE: optimal PEEP guided by G5 ventilator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mobile CARE-App to Promote Coping for Caregivers of Patients Receiving Stem Cell Transplant
Status: RECRUITING
Conditions: Bone Marrow Transplant Complications|Hematologic Malignancy
Interventions: BEHAVIORAL: CARE Application|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Oral Hygiene in Patients With Orthodontic Fixed Appliances
Status: UNKNOWN
Conditions: Oral Hygiene
Interventions: DEVICE: Manual toothbrush|DEVICE: Electric Toothbrush|DEVICE: Superfloss|DEVICE: Dental Water Jet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Treatment With Nilotinib in Adult Patients With Imatinib - Resistant or - Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Aspirin Pretreatment or Slow Dose Titration on Flushing and Gastrointestinal Events in Healthy Volunteers Receiving Delayed-release Dimethyl Fumarate
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BG00012 (dimethyl fumarate)|DRUG: BG00012 placebo|DRUG: ASA|DRUG: ASA placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Effects of Azithromycin, Telithromycin and Levofloxacin on Drug Metabolizing Enzymes
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cooperstown 5+1 alone|DRUG: Azithromycin plus Cooperstown 5+1|DRUG: Telithromycin plus Cooperstown 5+1|DRUG: Levofloxacin plus Cooperstown 5+1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Non-invasive Brain Stimulation in Adults Who Stutter
Status: TERMINATED
Conditions: Stuttering, Developmental
Interventions: DEVICE: Anodal tDCS|BEHAVIORAL: Fluency training|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Zirconia Crowns and Anterior Strip Crowns
Status: COMPLETED
Conditions: Dental Caries
Interventions: DEVICE: NuSmile Zirconia crowns by NuSmile company|DEVICE: Composite resin strip crowns by 3M company
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Laughter Yoga and Mindfulness-Based Stress Reduction (MBSR) Practices Applied to Women With Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Laughter Therapy|Mindfulness Therapy|Life Quality|Anxiety and Depression|Spiritual Well-being
Interventions: OTHER: the laughter yoga group|OTHER: the mindfulness based stress reduction group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Nasal Glucagon (LY900018) in Pediatric Participants With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Glucagon Nasal Powder [Baqsimi]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparative Analysis of Injectable Anticoagulants for Thromboprophylaxis Post Cancer-related Surgery
Status: COMPLETED
Conditions: Thrombosis, Venous
Interventions: DRUG: dalteparin|DRUG: enoxaparin|DRUG: fondaparinux|DRUG: unfractionated heparin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Single Agent Arsenic Trioxide in the Treatment of Newly Diagnosed Acute Promyelocytic Leukemia
Status: UNKNOWN
Conditions: Acute Promyelocytic Leukemia
Interventions: DRUG: Single agent arsenic trioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I, Pharmacokinetic, Safety and Tolerability Study in Healthy Volunteers
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vericiguat Drug-drug Interaction Study With Isosorbite Mononitrate in Stable Coronary Artery Disease Patients
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Vericiguat (BAY1021189)|DRUG: Placebo|DRUG: Isosorbide mononitrate (ISMN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Immunoglobulin (IVIg) for Parvovirus B19(PVB19) Mediated Cardiomyopathy
Status: COMPLETED
Conditions: Myocardial Diseases|Parvovirus B19, Human
Interventions: DRUG: Intravenous Immunoglobulins|DRUG: plasma volume expander
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VITAS: Atezolizumab in Combination With Chemotherapy for Pediatric Relapsed/Refractory Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor|Rhabdomyosarcoma
Interventions: DRUG: Atezolizumab|DRUG: Vincristine|DRUG: Irinotecan|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Lutetium-177 Labeled Girentuximab in Patients With Advanced Renal Cancer
Status: COMPLETED
Conditions: Metastatic Clear Cell Renal Cell Carcinoma
Interventions: DRUG: Lu-177-DOTA-girentuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Transcranial Magnetic Stimulation (TMS) in Central Post Stroke Pain ( CPSP)
Status: COMPLETED
Conditions: Central Post Stroke Pain
Interventions: DEVICE: navigated rTMS of motor cortex|DEVICE: navigated rTMS of somatosensory cortex 2|DEVICE: SHAM rTMS with SHAM block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgery With or Without Radiation Therapy and Chemotherapy in Treating Patients With Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: cisplatin|DRUG: fluorouracil|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diabetes and Combined Lipid Therapy Regimen (DIACOR) Study
Status: COMPLETED
Conditions: Type II Diabetes Mellitus|Mixed Dyslipidemia
Interventions: DRUG: fenofibrate 160 mg and placebo|DRUG: simvastatin 20 mg and placebo|DRUG: fenofibrate 160 mg and simvastatin 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Integrating Treatment for Mental Disorders in Methadone Clinics in Ukraine
Status: ACTIVE_NOT_RECRUITING
Conditions: Depression|Opioid Use Disorder
Interventions: OTHER: Project ECHO|OTHER: Payment for Performance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Interceptive Strategies on the Clinical Outcome of Maxillary Impacted Canines
Status: RECRUITING
Conditions: Tooth, Impacted
Interventions: PROCEDURE: Maxillary expansion|PROCEDURE: Extraction of deciduous upper canines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Overeating Different Fats and Influence on Muscle Mass and Body Fat Accumulation
Status: COMPLETED
Conditions: Obesity|Overfeeding|Muscle Mass|Body Composition|Ectopic Fat
Interventions: DIETARY_SUPPLEMENT: PUFA-group|DIETARY_SUPPLEMENT: SFA-group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A 2 PART STUDY EVALUATING EDP-721 IN HEALTHY SUBJECTS AND EDP-721 IN COMBINATION WITH EDP-514 IN PATIENTS WITH CHRONIC HEPATITIS B VIRUS INFECTION.
Status: TERMINATED
Conditions: Chronic Hepatitis B Virus Infection
Interventions: DRUG: EDP-721|DRUG: Placebo (Part 1)|DRUG: EDP-721 (Part 2)|DRUG: Placebo (Part 2)|DRUG: EDP-514|DRUG: Placebo (Part 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Deep Phenotyping for Clinical Inferring Response in Treatment Resistant Depression
Status: RECRUITING
Conditions: Depressive; Disorder, Major, Single Episode, Major, With Psychotic Symptoms|Depressive; Disorder, Major, Single Episode, Major (Without Psychotic Symptoms)|Depressive Disorder, Major, Recurrent, With Psychotic Symptoms|Depressive Disorder, Major, Recurrent, Without Psychotic Symptoms|Depressive Disorder, Treatment-Resistant, Class I or II|Depressive Disorder, Major, Moderate|Depressive Disorder, Major, Severe
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Quintuple Therapy to Treat COVID-19 Infection
Status: COMPLETED
Conditions: COVID-19|Corona Virus Infection|Coronavirus-19|Sars-CoV2
Interventions: DRUG: Hydroxychloroquine|DRUG: Azithromycin|DIETARY_SUPPLEMENT: Vitamin C|DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: Zinc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SPiT-frequency; the Effect of Increased Frequency of Intervention on Post-surgical Peri-implant Inflammation
Status: NOT_YET_RECRUITING
Conditions: Peri-Implantitis
Interventions: OTHER: Submucosal supportive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Studying Genes in Blood and Lung Fluid Samples From Patients With Chronic Obstructive Pulmonary Disease With or Without a Previous Diagnosis of Lung Cancer or With Asthma Treated With Budesonide and Formoterol
Status: COMPLETED
Conditions: Lung Cancer|Precancerous Condition
Interventions: DRUG: budesonide/formoterol fumarate dihydrate inhalation aerosol|GENETIC: DNA methylation analysis|GENETIC: comparative genomic hybridization|GENETIC: microarray analysis|OTHER: bronchoalveolar lavage|OTHER: immunoenzyme technique|OTHER: laboratory biomarker analysis|PROCEDURE: bronchoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Antimicrobial, Post Operative Pain of Cinnamon Extract Versus Sodium Hypochlorite Irrigant Following Pulpectomy of Primary Teeth
Status: RECRUITING
Conditions: Irreversible Pulpitis|Caries,Dental
Interventions: OTHER: Irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Three-Arm Trial of Novel Treatment for Tinea Pedis
Status: COMPLETED
Conditions: Tinea Pedis
Interventions: DRUG: Experimental Drug SESC 01|DRUG: Placebo|DRUG: Terbinafine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Benefits of Preoperative Nutrition Support With Enteral Immune-enhancing Formulas in Surgical Oncology
Status: WITHDRAWN
Conditions: CANCER
Interventions: DIETARY_SUPPLEMENT: SUPPORTAN + GLUTAMINE PLUS|DIETARY_SUPPLEMENT: NO PREOPERATIVE NUTRITION SUPPORT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Medication Reviews Bridging Healthcare: a Cluster-randomised Crossover Trial
Status: COMPLETED
Conditions: Medication Review
Interventions: PROCEDURE: Comprehensive medication review|PROCEDURE: Comprehensive medication review with active follow-up|PROCEDURE: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pharmacokinetic Study of 48-hour Sevoflurane Inhalation Using a Disposable Delivery System (AnaConDa©) in Obese ICU Patients
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Sedation with sevoflurane during 48-hr in ICU
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial to Improve Mother-Infant Synchrony Among Women With Childhood Adversity
Status: ACTIVE_NOT_RECRUITING
Conditions: Parent-Child Relations|Maternal Behavior|Infant Behavior
Interventions: BEHAVIORAL: ATVV|BEHAVIORAL: Attention control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Long COVID-19 Wearable Device Study
Status: RECRUITING
Conditions: Long COVID|Postural Orthostatic Tachycardia Syndrome|Dysautonomia|Myalgic Encephalomyelitis|Chronic Fatigue Syndrome|Long Covid19
Interventions: DEVICE: Wearable device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Comparison of Neuromuscular Electrical Stimulation and Intermittent Pneumatic Compression in Terms of Lower Limb Blood Flow
Status: COMPLETED
Conditions: Venous Thrombosis
Interventions: DEVICE: Duo-STIM neuromuscular electrical stimulator|DEVICE: AV Impulse System Model 6000
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nd:YAG Laser Versus Diode Laser Assisted New Attachment Procedure (Lanap) in the Management of Stage II Periodontitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Periodontitis
Interventions: DEVICE: LANAP surgical protocol using ND:YAG 1064 laser|DEVICE: LANAP surgical protocol using diode 940 laser|PROCEDURE: Scaling and root planing (SRP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Platelet Rich Plasma (PRP) on Post Operative Pain in Anterior Cruciate Ligament Reconstruction
Status: COMPLETED
Conditions: Post Operative Pain
Interventions: PROCEDURE: Anterior Cruciate ligament reconstruction bone patellar tendon bone autograft|BIOLOGICAL: Platelet Rich Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Different Types of Electrostimulation Probes During IONM
Status: COMPLETED
Conditions: Thyroid Diseases
Interventions: DEVICE: Bipolar and monopolar probes (SPESS MEDICA S.r.l. Via Buccari 16153 Genova (GE), Italy) administered to all participants.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Digital Follow-up Program for People With Chronic Obstructive Pulmonary Disease in Primary Healthcare
Status: RECRUITING
Conditions: COPD Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: Guided self-determination (GSD) follow-up approach by primary care nurses.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Postoperative Use of Low-Dose Combined Oral Contraceptivesfor for Endometriosis-Related Chronic Pelvic Pain
Status: UNKNOWN
Conditions: Endometriosis|Chronic Pelvic Pain
Interventions: DRUG: Continuous OC (clormadinone acetate plus ethinil-estradiol - Belara®, Grunenthal, Milan, Italy)|DRUG: Cyclic OC (clormadinone acetate plus ethinil-estradiol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Second-hand Smoke Exposure Among Young Children in Rural China
Status: COMPLETED
Conditions: Second Hand Tobacco Smoke
Interventions: BEHAVIORAL: Smoking hygiene intervention|BEHAVIORAL: Placebo intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Vibration on Pain During Subcutaneous Heparin Injection
Status: COMPLETED
Conditions: Pain|Asthma|Pulmonary Disease|Chest Disorder
Interventions: DEVICE: Vibration|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Effects of Oral Administration of Lixivaptan in Patients With Congestive Heart Failure
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: DRUG: Lixivaptan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sustained Acoustic Medicine (SAM) for Symptomatic Treatment of Knee Pain Related to Osteoarthritis
Status: COMPLETED
Conditions: Osteo Arthritis Knee|Arthritis
Interventions: DEVICE: Sustained Acoustic Device with 2.5% Diclofenac Patch|DEVICE: Sustained Acoustic Device with 0% Diclofenac Patch|DRUG: 2.5% Diclofenac Patches
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sofosbuvir/Velpatasvir Fixed Dose Combination for 12 Weeks in Adults With Chronic Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV)-1 Coinfection
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: SOF/VEL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Followed by Surgery and Neoadjuvant Hemothoracic Intensity Modified Radiation Therapy (IMRT) for Patients With Malignant Pleural Mesothelioma
Status: TERMINATED
Conditions: Mesothelioma|Solitary Fibrous Tumor of the Pleura
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: AI Detection of Incidental Coronary Artery Calcium to Enhance Cardiovascular Disease Prevention
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: Electronic health record-based notification of Nanox.AI Coronary Artery Calcification Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SUSY Study (SUture StudY) Comparing Scarring With Polypropylene vs Polyglactin 910 Sutures
Status: SUSPENDED
Conditions: Entropion|Inflammation in the Eyelid
Interventions: DEVICE: suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Glucose Control in the ICU Using Continuous Glucose Monitoring
Status: COMPLETED
Conditions: Critical Illness
Interventions: DEVICE: experimental: real-time continuous glucose monitoring|DEVICE: Active comparator: blinded continuous glucose monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab and Tremelimumab in Treating Chemotherapy Naive Patients With Metastatic Castration-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Castration-Resistant Prostate Carcinoma|Metastatic Malignant Neoplasm in the Bone|Prostate Adenocarcinoma|Stage IV Prostate Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8|Stage IVB Prostate Cancer AJCC v8
Interventions: BIOLOGICAL: Durvalumab|BIOLOGICAL: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of a Preoperative, Multimodal Lifestyle Intervention in Patients With Breastcancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Breast Neoplasms
Interventions: BEHAVIORAL: A multimodal prehabilitation programme
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Implementation of a Patient-centered, Reproductive Planning Decision Support Tool (MyPath) Among Women With Substance Use Disorder in the Immediate Postpartum Period
Status: RECRUITING
Conditions: Substance Use Disorders|Pregnancy Related|Contraception
Interventions: BEHAVIORAL: MyPath Intervention|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Transdisciplinary Intervention Integrating Geriatric And Palliative Care With Oncology Care For Older Adults With Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: OTHER: Usual Oncology Care|OTHER: Transdisciplinary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomized Controlled Trial of Standard ERP and OC-Go
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: BEHAVIORAL: Exposure and Response Prevention|BEHAVIORAL: OC-Go
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Compare the Bioavailability of HR17031 in Healthy Subjects at Different Sites
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: HR17031|DRUG: HR17031|DRUG: HR17031
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Modified Process Hib/Hep B Vaccine in Infants (V121-019)(COMPLETED)
Status: COMPLETED
Conditions: Haemophilus Influenzae Type B|Hepatitis B
Interventions: BIOLOGICAL: Comparator: Modified Process Vaccine|BIOLOGICAL: Comparator: COMVAX™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Performance of Y-STRUT® Medical Device to Strengthen Pre-fractural Tumour-induced Lesions at the Level of the Proximal Femur
Status: TERMINATED
Conditions: Pathological Fracture of Hip|Bone Metastases
Interventions: DEVICE: Y-STRUT® (Hyprevention, Pessac, France)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Understand the Effect of Itraconazole on the Levels of a Study Medicine Called ARV-471 in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ARV-471|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Investigate Vamikibart in Participants With Uveitic Macular Edema
Status: ACTIVE_NOT_RECRUITING
Conditions: Uveitic Macular Edema
Interventions: DRUG: Vamikibart|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Stellate Ganglion Block in Breast Cancer Related Lymphedema
Status: UNKNOWN
Conditions: Lymphedema of Upper Limb|Breast Cancer Related Lymphedema
Interventions: COMBINATION_PRODUCT: bupivacaine and triamcinolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cells in the Treatment of Long COVID-19
Status: WITHDRAWN
Conditions: Long COVID-19
Interventions: BIOLOGICAL: UC-MSCs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characterizing the Immune Response and Neuronal Damage in COVID-19
Status: COMPLETED
Conditions: SARS-CoV Infection|Covid-19
Interventions: OTHER: Analysis of cytokine response, innate and adaptive immune response, complement activation, and serum neurofilaments as a marker of neurological damage.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of CST-2032 in Subjects With Cognitive Impairment
Status: WITHDRAWN
Conditions: Mild Cognitive Impairment (MCI)|Parkinson Disease (PD)
Interventions: DRUG: CST-2032, matching placebo for CST-2032, CST-107
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: In UTERO Treatment of Cytomegalovirus Congenital Infection With Valacyclovir
Status: TERMINATED
Conditions: Viral Disease|Cytomegalovirus Infection
Interventions: DRUG: Valacyclovir (ZELITREX)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Electrostimulation for Intermittent Claudication Supervised Walking Therapy for Intermittent cLAudication
Status: UNKNOWN
Conditions: Intermittent Claudication|Peripheral Arterial Disease
Interventions: DEVICE: transcutaneous electrical calf muscle stimulation + supervised walking therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Close Assessment and Testing for Chronic Graft Versus Host Disease, CATCH Study
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Optical Coherence Tomography|PROCEDURE: Spirometry|OTHER: Survey Administration|OTHER: Digital Photography|OTHER: Quality-of-Life Assessment|OTHER: Medical Chart Review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial Comparing Laparoscopic Vs Robotic-assisted Colposacropexy for Pelvic Organ Prolapse Repair
Status: UNKNOWN
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: sacrocolpopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory, Multi-cohort Phase II Study of Combination Therapy With AK104 and AK112 for Recurrent Ovarian Cancer
Status: NOT_YET_RECRUITING
Conditions: Recurrent Ovarian Cancer
Interventions: DRUG: AK104|DRUG: AK112|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LDK378 Versus Chemotherapy in ALK Rearranged (ALK Positive) Patients Previously Treated With Chemotherapy (Platinum Doublet) and Crizotinib
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Ceritinib|DRUG: pemetrexed|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Aerobic Exercise Associated With Abdominal Radiofrequency on on Adipose Tissue in Women:
Status: COMPLETED
Conditions: Cardiovascular Risk Factor|Metabolic Disease
Interventions: DEVICE: Radiofrequency|DEVICE: Radiofrequency without power|DEVICE: Aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Liposomal Irinotecan, S-1, and Oxaliplatin in Advanced Pancreatic Adenocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer|Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: NASOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of tDCS With Gait Training on Leg Performance in Incomplete Spinal Cord Injury
Status: COMPLETED
Conditions: Incomplete Spinal Cord Injury
Interventions: DEVICE: transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reverse Walking With And Without Whole Body Vibration in Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: Reverse Walking+Baseline treatment|OTHER: Whole Body Vibration + Reverse Walking+Baseline treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Different Autologous Products in The Treatment of Intrabony Defects
Status: COMPLETED
Conditions: Periodontal Pocket
Interventions: PROCEDURE: autologous products
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cross-Over Study to Evaluate the Efficacy of E-PR-01 on Activity Induced Joint Pain
Status: COMPLETED
Conditions: Joint Pain
Interventions: OTHER: E-PR-01|OTHER: E- PR-02
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Transcranial Direct Current Stimulation (tDCS) as a Cognitive Enhancer for Patients With Alzheimers Disease
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: OTHER: tDCS|OTHER: Placebo tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open Label Study of Multiple Doses of Cannabidiol in the Prevention of Acute Graft-Versus-Host Disease (GVHD)
Status: UNKNOWN
Conditions: Prevention aGVHD
Interventions: DRUG: CBD
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Long-term Oxygen Therapy on Exercise Capacity and Quality of Life in Patients With Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension
Interventions: PROCEDURE: long term oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Panlongqi Tablet in Patients With Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DRUG: Treatment of Panlongqi Tablet|DRUG: Treatment of Panlongqi placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis
Status: COMPLETED
Conditions: Aggressive Periodontitis
Interventions: OTHER: scaling and systemic moxifloxacin|OTHER: scaling and root planing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Switch to Genvoya Followed by HCV Therapy With Epclusa Followed by Simplification of HIV Therapy With Biktarvy in Patients With HIV-HCV Co-Infected Subjects on Opioid Substitution Therapy
Status: UNKNOWN
Conditions: HIV-1-infection|Hepatitis C, Chronic|Methadone Dependence|Opioid Dependence|Bone Diseases, Metabolic|HIV/AIDS|Co-infection|Buprenorphine Dependence|HCV Coinfection
Interventions: DRUG: Genvoya|DRUG: Epclusa|DRUG: Biktarvy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Covid-19 on Frequent Social Interaction Through Communication Technologies in the Cognitive Status of Socially-isolated Older Adults
Status: COMPLETED
Conditions: Memory Disorders|Alzheimer Disease|Mild Cognitive Impairment
Interventions: BEHAVIORAL: Technology based social interactions|OTHER: No research related technology based social interactions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Sildenafil To Prevent Clot
Status: COMPLETED
Conditions: Thrombosis|Hemolysis
Interventions: DRUG: Sildenafil|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Binocular Visual Therapy and Video Games for Amblyopia Treatment.
Status: RECRUITING
Conditions: Amblyopia
Interventions: DEVICE: Red/green glasses|DEVICE: Electronic Tablet|DEVICE: Eye patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Post Implantation Syndrome and Administration on NSAIDs in Patients Undergoing EVAR for AAA
Status: UNKNOWN
Conditions: Aneurysm Abdominal|Endovacular Repair
Interventions: DRUG: Drugs, Generic (Naprosyn)|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of EGb761 in Patients Suffering From Friedreich Ataxia
Status: COMPLETED
Conditions: Friedreich Ataxia
Interventions: DRUG: EGb 761 120 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Attachment Types for Single-implant Mandibular Overdentures: a Crossover Clinical Trial
Status: COMPLETED
Conditions: Edentulous Mouth|Complete Edentulism
Interventions: DEVICE: O'Ring Attachment (A)|DEVICE: Equator Attachment (B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: New Stereotactic Frame System for Neurosurgery
Status: WITHDRAWN
Conditions: Parkinson Disease|Essential Tremor|Dystonia|Tourette Syndrome|Obsessive-Compulsive Disorder
Interventions: DEVICE: DBS Electrode Implantation using D1 Sterotactic System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Well-being Training for Preservice Teachers
Status: COMPLETED
Conditions: Burnout, Professional|Stress, Psychological|Well-being|Psychological Adjustment|Self-regulation
Interventions: BEHAVIORAL: novel mindfulness-based well-being training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of Adenovirus Serotype 26 Based Respiratory Syncytial Virus Pre-fusion (Ad26.RSV.Pre-F) Vaccine in RSV-Seronegative Toddlers 12 to 24 Months of Age
Status: COMPLETED
Conditions: Respiratory Syncytial Virus
Interventions: BIOLOGICAL: Ad26.RSV.preF|BIOLOGICAL: Placebo|BIOLOGICAL: Nimenrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Steroid Supplementation After TMJ Rinsing for Pain Management
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Lactated Ringers|DRUG: Triamcinolone hexacetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ghrelin Regulation and Structure: Effect of Diet Composition on Ghrelin
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Low fat diet|DIETARY_SUPPLEMENT: High fat diet|DIETARY_SUPPLEMENT: MCT diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Two Analgesic Strategies After Scheduled Caesarean
Status: COMPLETED
Conditions: Analgesia
Interventions: DRUG: Rachianesthesia|DRUG: Sodium Chloride Injection|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CCI-779 in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Metastatic Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neonatal Hypoxic Ischemic Encephalopathy:Early Diagnosis and Management of Comorbidities
Status: UNKNOWN
Conditions: Neonatal Hypoxic Ischemic Encephalopathy
Interventions: DIAGNOSTIC_TEST: magnetic resonant imaging,cranial ultrasound.|DIAGNOSTIC_TEST: Amplitude integrated electroencephalogram
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phosphorus-32 Plus Radiation Therapy and Chemotherapy in Treating Patients With Stage II or Stage III Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: vinblastine sulfate|RADIATION: phosphorus P32|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Trial of Selinexor (KPT-330) With Docetaxel for Non-small Cell Lung Cancer (NSCLC)
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Selinexor|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of an Opioid-Free Anesthesia Protocol Versus Standard Practices on Early and Late Post-operative Recovery
Status: UNKNOWN
Conditions: Anesthesia|Anesthesia; Adverse Effect|Opioid Analgesic Adverse Reaction|Post-Op Complication
Interventions: DRUG: Opioid Free Anaesthesia protocol|DRUG: standard practice protocol based on the use of opioids (sufentanil or remifentanil)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Alkalinization by Urologists & Nephrologists
Status: COMPLETED
Conditions: Metabolic Acidosis|Nephrolithiasis|Extracellular Alteration|Blood Pressure|Body Weight
Interventions: DRUG: Alkali
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trail of CDK4 / 6 Inhibitor and MEK Inhibitor in the Treatment of Metastatic Digestive System Tumors
Status: UNKNOWN
Conditions: Digestive System Tumors
Interventions: DRUG: a CDK4 / 6 inhibitor and a MEK inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Increasing Vegetable Intake Using Monosodium Glutamate: A Reduced-Effort Intervention
Status: COMPLETED
Conditions: Healthy Nutrition|Culinary Medicine|Sodium Excess
Interventions: BEHAVIORAL: Salt replacement seasoning (50% salt and 50% MSG) mix|BEHAVIORAL: Salt replacement seasoning (70% salt and 30% MSG) mix|BEHAVIORAL: NaCl (sodium chloride/table salt)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Drug Interactions Between HGP1607 and HGP1501
Status: COMPLETED
Conditions: Healthy Male Volunteers
Interventions: DRUG: HGP1607|DRUG: HGP1501|DRUG: HGP1607+HGP1501
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT