pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Pembrolizumab Combined With Chemotherapy in the First Line Therapy for R/M HNSCC in China
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Pembrolizumab combined with Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telerehabilitation in Lung Surgery Patients
Status: RECRUITING
Conditions: Lung Cancer|Physiotherapy
Interventions: OTHER: Breathing exercise, intensive spirometry use, supported cough, progressive mobilisation and ambulation|OTHER: Exercise booklet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Preventive Negative Pressure Wound Therapy With PICO on Surgical Wounds of Kidney Transplant Patients
Status: WITHDRAWN
Conditions: Wound Complications
Interventions: DEVICE: portable (pocket) negative pressure wound treatment device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Randomized Clinical Trial of a Mindfulness Based Intervention in Generalized Anxiety Disorder
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: BEHAVIORAL: Body in Mind Training (BMT)|DRUG: Fluoxetine|BEHAVIORAL: Quality of Life Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Collaborative Cardiac Care Project
Status: COMPLETED
Conditions: Myocardial Ischemia|Angina Pectoris|Coronary Disease
Interventions: PROCEDURE: Collaborative care model|PROCEDURE: Group interventions|PROCEDURE: Facilitated consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS)
Status: COMPLETED
Conditions: Preterm Birth|Pregnancy|Multifetal
Interventions: DRUG: 17 alpha-hydroxyprogesterone caproate (17P)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Edulcorants Effect in Caries Risk Schoolchildren
Status: COMPLETED
Conditions: Dental Caries
Interventions: DIETARY_SUPPLEMENT: delivery of snacks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Enchasing Polyp Detection: The Effect of Adding Polyp Detection Attachment Device to Computer Aid Detection System.
Status: ENROLLING_BY_INVITATION
Conditions: Colon Cancer Screening|Colon Cancer Surveillance
Interventions: DEVICE: Endocuff and GI Genius|DEVICE: GI Genius
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Ticagrelor Removal Study Using CytoSorb® 300 mL Device During CPB in Patients Undergoing Emergent Cardiothoracic Surgery
Status: TERMINATED
Conditions: Acute Coronary Syndrome
Interventions: PROCEDURE: Blood sampling and analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PROGRESS Trial - Prophylactic Gabapentin for Relief of Symptoms and Improved Swallowing
Status: WITHDRAWN
Conditions: Oropharyngeal Cancer|HPV-Related Squamous Cell Carcinoma
Interventions: DRUG: Gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cerebellar Modulation of Cognition in Psychosis
Status: RECRUITING
Conditions: Schizophrenia|Schizoaffective Disorder|Bipolar Disorder I|Psychosis
Interventions: DEVICE: intermittant theta burst stimulation (iTBS)|DEVICE: continuous theta burst stimulation (cTBS)|DEVICE: sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Face to Face vs. Group Training Methods on Pulse Rate Taking in Patients With Cardiovascular Diseases.
Status: UNKNOWN
Conditions: Arrythmia
Interventions: OTHER: Face-to-face training|OTHER: Group training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Doxycycline Monohydrate 25 mg (5mL) Oral Suspension Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Doxycycline Monohydrate|DRUG: Doxycycline Monohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Determine the Utility of Novel Technologies and Biomarkers to Measure Human Response to Rosiglitazone Maleate
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: rosiglitazone maleate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: RM1 Project 2 - tAN fMRI
Status: RECRUITING
Conditions: Auricular Stimulation
Interventions: DEVICE: Transcutaneous Auricular Neruostimulation (tAN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Effectiveness of DM199 in Healthy Subjects and Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Diabetes Type 2
Interventions: DRUG: DM199|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of TAR-200 Versus Intravesical Chemotherapy in Participants With Recurrent High-Risk Non-Muscle-Invasive Bladder Cancer (HR-NMIBC) After Bacillus Calmette-Guérin (BCG)
Status: RECRUITING
Conditions: Non-Muscle Invasive Bladder Neoplasms
Interventions: DRUG: TAR-200|DRUG: Mitomycin C|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Slow-Release Oral Morphine for the Treatment of Opioid Use Disorder
Status: TERMINATED
Conditions: Opioid-Related Disorders|Opiate Substitution Treatment|Morphine|Methadone|Fentanyl
Interventions: DRUG: Slow release oral morphine (SROM)|DRUG: Methadone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ga-DOTATATE PET for Phosphaturic Mesenchymal Tumors in Patients With Tumor Induced Osteomalacia
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteomalacia
Interventions: COMBINATION_PRODUCT: 68Ga-DOTATATE PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Role of Artificial Intelligence in the Treatment of Abdominal Aortic Aneurysms
Status: NOT_YET_RECRUITING
Conditions: Frequency of Embolic Complications|Frequency of Ischemic Complications
Interventions: PROCEDURE: prosthetics of the abdominal aorta|PROCEDURE: prosthetics of the abdominal aorta after determining the safe zones of clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Oral Chloral Hydrate and Combination of Intranasal Dexmedetomidine and Ketamine for Rescue After Failed Pediatric Procedural Sedation
Status: RECRUITING
Conditions: Sedation
Interventions: DRUG: Intranasal dexmedetomidine and ketamine|DRUG: Oral chloral hydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Affect of Hemostasis Technique During Laparoscopic Ovarian Cystectomy on Future Fertility
Status: COMPLETED
Conditions: Cyst Ovary
Interventions: DEVICE: Bipolar coagulation forceps (ETHICON inc.)|DEVICE: SURGIFLO hemostatic matrix (ETHICON inc.)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Revascularization Pretreated With Fingolimod in Acute Stroke
Status: UNKNOWN
Conditions: Stroke
Interventions: DRUG: Fingolimod|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Health Education vs. Health Education Plus Physical Therapy for Low Back Pain Patients
Status: COMPLETED
Conditions: Low Back Pain
Interventions: BEHAVIORAL: General health talk|BEHAVIORAL: Handout of The Back Book|BEHAVIORAL: Back exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ketamine Versus Magnesium as Analgesic Adjuvants in Pediatric Adenotonsillectomy
Status: COMPLETED
Conditions: Post Operative Pain, Acute
Interventions: DRUG: Ketamine hydrochloride|DRUG: Magnesium sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Clinical Study on Qianjin Capsule of Gynaecology Combined With Antibiotics for Pelvic Inflammatory Diseases (Damp-heat Stasis and Qi Deficiency Syndrome)
Status: UNKNOWN
Conditions: Pelvic Inflammatory Diseases
Interventions: DRUG: Qianjin Capsule of Gynaecology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BRAF/MEK Inhibition in Relapsed/Refractory Multiple Myeloma (BIRMA)
Status: COMPLETED
Conditions: Relapsed or Refractory Multiple Myeloma|Patients With BRAFV600 E or BRAFV600K Mutation
Interventions: DRUG: Encorafenib|DRUG: Binimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adapting and Testing a Novel Digital Health Tool (PREVENT) to Improve Health Behavior Counseling and Cardiovascular Health in Rural Primary Care Clinics
Status: NOT_YET_RECRUITING
Conditions: Obesity|Cardiovascular Diseases
Interventions: BEHAVIORAL: PREVENT|BEHAVIORAL: Wait-list Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Primary Hyperparathyroidism: Short-term Calcimimetics Treatment - Relevance for Parathyroid Surgery Decisions?
Status: COMPLETED
Conditions: Primary Hyperparathyroidism
Interventions: DRUG: Cinacalcet|PROCEDURE: parathyroid adenomectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The PRISM-Social Needs (PRISM-SN) Intervention for Adolescents and Young Adults With Cancer
Status: RECRUITING
Conditions: Cancer|Social Functioning|Psychosocial Functioning|Coping Skills
Interventions: BEHAVIORAL: Promoting Resilience in Stress Management - Social Needs (PRISM-SN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Motexafin Gadolinium, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma
Status: COMPLETED
Conditions: Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma
Interventions: RADIATION: 3-Dimensional Conformal Radiation Therapy|DRUG: Motexafin Gadolinium|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Newly Developed Pictogram Cards and Their Utility in Improving Inhaler Techniques in Asthmatic Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Asthma
Interventions: OTHER: Counselling by the Trained Pharmacist|OTHER: Pictograms Cards and Counselling by the Trained Pharmacist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hematopoietic Stem Cell Transplantation (HCT) for Inborn Errors of Metabolism
Status: TERMINATED
Conditions: Hurler's Syndrome|Maroteaux-Lamy Syndrome|Sly Syndrome|Alpha Mannosidosis|Fucosidosis|Aspartylglucosaminuria|Sphingolipidoses|Krabbe Disease|Wolman's Disease|Niemann-Pick Disease Type B|Niemann-Pick Disease, Type C
Interventions: PROCEDURE: Stem Cell Transplantation|DRUG: Cyclophosphamide|DRUG: Campath-1H|DRUG: Busulfan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of IM21 Car-t Cells in Patients With Recurrent or Refractory BCMA Positive Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: IM21 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of 23-valent Pneumococcal Polysaccharide Vaccine in Healthy Chinese Population Aged 2 Years and Above
Status: COMPLETED
Conditions: Pneumonia
Interventions: BIOLOGICAL: 23-valent pneumococcal polysaccharide vaccine|BIOLOGICAL: pneumococcal vaccine polyvalent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Concurrent Chemoradiotherapy Combined With Immunotherapy in Patients With Potentially Resectable Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Carcinoma
Interventions: DRUG: Tislelizumab|DRUG: Gemcitabine|DRUG: Nab paclitaxel|RADIATION: Hypofractionated radiotherapy with simultaneous integrated boost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention to Improve Driving Practices Among High-Risk Teen Drivers
Status: RECRUITING
Conditions: Drive|Recidivism|Communication|Feedback, Psychological
Interventions: COMBINATION_PRODUCT: In-vehicle device|BEHAVIORAL: Parent Communication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating ECG Effects, Safety, Tolerability and Pharmacokinetics of Single Doses of Modufolin (Arfolitixorin) in Healthy Volunteers Tetrahydrofolate in Healthy Male Volunteers
Status: COMPLETED
Conditions: Phase I Study in Healthy Volunteers to Evaluate ECG Effect
Interventions: DRUG: Modufolin (arfolitixorin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparing X-3 To N2vac Polyethylene With the Triathlon Total Knee System
Status: WITHDRAWN
Conditions: Osteoarthritis|OA
Interventions: DEVICE: X-3 polyethylene|DEVICE: N2Vac polethylene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-NY-ESO-1 TCR-Gene Engineered Lymphocytes Given by Infusion to Patients With NY-ESO-1 -Expressing Metastatic Cancers
Status: RECRUITING
Conditions: Sarcoma, Synovial|Sarcoma,Soft Tissue|Melanoma Stage IV|Triple Negative Breast Cancer|Metastatic Cancer|Non Small Cell Lung Cancer|Bladder Urothelial Carcinoma|Neuroblastoma, Metastatic|Ovary Cancer
Interventions: DRUG: CYCLOPHOSPHAMIDE and FLUDARABIN|DRUG: Cyclophosphamide|BIOLOGICAL: HBI 0201-ESO TCRT|DRUG: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of ACH24 in the Treatment of Vitiligo
Status: WITHDRAWN
Conditions: Vitiligo
Interventions: DRUG: Group 01|DRUG: Group 02
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Preliminary Efficacy of Hatha Yoga in Head and Neck Cancer Survivors
Status: COMPLETED
Conditions: Head Neck Cancer
Interventions: OTHER: Baseline Study Measures|BEHAVIORAL: Yoga Evaluation|BEHAVIORAL: Yoga Program|BEHAVIORAL: Yoga Practice Plan|OTHER: Study Assessments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Effect of Renal Impairment on the PK of Tenofovir Exalidex
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Tenofovir Exalidex (TXL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy of Two Doses of Ferrlecit in the Treatment of Iron Deficiency in Pediatric Hemodialysis Patients
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Ferrlecit (sodium ferric gluconate complex in sucrose injection)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Twice-daily Tacrolimus and Everolimus Convert to Once-daily Tacrolimus and Everolimus in Liver Transplant Recipient
Status: COMPLETED
Conditions: Liver Transplantation
Interventions: DRUG: Tacrolimus and Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Safety, Tolerability, Preliminary Efficacy of Intra-articular LNA043 Injections in Patients With Articular Cartilage Lesions and Knee Osteoarthritis.
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: BIOLOGICAL: LNA043|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose-Finding Study of MM-120 (LSD D-Tartrate) for the Treatment of Anxiety Symptoms
Status: COMPLETED
Conditions: Anxiety Generalized
Interventions: DRUG: MM-120 (LSD D-Tartrate)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnesium Sulphate for Treatment of New Onset Atrial Fibrillation in Medical Intensive Care Unit Patient
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DRUG: Placebo|DRUG: Magnesium sulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: tDCS for Treatment of Depression in Parkinson's Disease
Status: UNKNOWN
Conditions: Idiopathic Parkinson Disease|Depression
Interventions: DEVICE: Transcranial direct current stimulation|DEVICE: Sham Transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of Protective Effects of OpalSeal™ Against Early Dental Decay in Orthodontic Patients
Status: COMPLETED
Conditions: Cavities of Teeth
Interventions: DEVICE: OpalSeal|DEVICE: TransbondXT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Gertner Tele-Motion-Rehabilitation System for Stroke Rehabilitation
Status: UNKNOWN
Conditions: Stroke
Interventions: BEHAVIORAL: Home-based self training exercises for weak upper extremity|BEHAVIORAL: Tele-rehabilitation exercises for weak upper extremity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Imiquimod and Abraxane in Treating Patients With Advanced Breast Cancer
Status: COMPLETED
Conditions: Male Breast Cancer|Recurrent Breast Cancer|Skin Metastases|Stage IV Breast Cancer
Interventions: DRUG: imiquimod|DRUG: Abraxane|OTHER: laboratory biomarker analysis|GENETIC: RNA analysis|OTHER: immunoenzyme technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Sacroiliac Joint Manual Therapy on Autonomic Nervous System and Lower Abdominal Pain in Women in Their 20s With Primary Dysmenorrhea
Status: COMPLETED
Conditions: Primary Dysmenorrhea
Interventions: BEHAVIORAL: spine manual therapy|DEVICE: Superficial heat therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nicotine Patch as an Adjunctive Intervention to Reduce Secondhand Smoke Among NICU Families
Status: COMPLETED
Conditions: Environmental Tobacco Smoke|Smoking Cessation
Interventions: DRUG: nicotine replacement therapy (NRT)|BEHAVIORAL: motivational advice|BEHAVIORAL: Quitline referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ambulatory Oxygen Therapy for Individuals With Mild-to-moderate Interstitial Lung Disease
Status: NOT_YET_RECRUITING
Conditions: Fibrotic Interstitial Lung Disease
Interventions: DRUG: Exertional Oxygen|BEHAVIORAL: Education and Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Diagnostic Value of PET (18F-FDG) in Chronic Graft Versus Host Disease (cGVH)
Status: UNKNOWN
Conditions: Chronic Graft Versus Host Disease
Interventions: PROCEDURE: PET (18-FDG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical and Radiological Results of Osteochondral Repair Using MaioRegen in Knee and Ankle Surgery
Status: UNKNOWN
Conditions: Osteochondral Lesion of Talus|Degenerative Lesion of Articular Cartilage of Knee
Interventions: DEVICE: implantation of MaioRegen fleece into osteochondral lesion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydrocolloid Dressing for Catheter Exit Site Care in Peritoneal Dialysis Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Peritoneal Dialysis Catheter Exit Site Infection
Interventions: DEVICE: hydrocolloid dressing|DRUG: Gentamicin Sulfate, Topical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Robot- Versus Mirror-Assisted Rehabilitation in Stroke Patients
Status: UNKNOWN
Conditions: Cerebrovascular Accident
Interventions: BEHAVIORAL: Mirror Therapy|BEHAVIORAL: Robotic assisted therapy|BEHAVIORAL: Robotic Rehabilitation with PI|BEHAVIORAL: Robotic rehabilitation with FES|BEHAVIORAL: Conventional Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Safety, Tolerability, and the Effects Two ND-L02-s0201 Have on the Body
Status: COMPLETED
Conditions: Fibrosis
Interventions: DRUG: ND-L02-s0201
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cognitive and Motor Benefits of Standing
Status: UNKNOWN
Conditions: Pain, Acute|Muscle Tone Abnormalities|Work-Related Condition|Sensory Deficit
Interventions: BEHAVIORAL: Sitting|BEHAVIORAL: Static standing|BEHAVIORAL: Dynamic standing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Home-based Wearable Device and Supervised PFMT on SUI/MUI
Status: RECRUITING
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: PFMT with device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TACE Combined With PD-1 Knockout Engineered T Cell in Advanced Hepatocellular Carcinoma.
Status: RECRUITING
Conditions: Advanced Hepatocellular Carcinoma
Interventions: PROCEDURE: Transcatheter arterial chemoembolization|BIOLOGICAL: PD-1 knockout engineered T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Primary Prevention Intervention for the Promotion of Psycho-social Wellbeing in Adolescent Young Carers:
Status: COMPLETED
Conditions: Adolescent - Emotional Problem|Mental Health Wellness 1|Caregivers|Primary Prevention|Cognitive Therapy
Interventions: BEHAVIORAL: Psycho-educational sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial of an Injectable Biologic and U0279 as Combination Therapy for Severe Plaque-Type Psoriasis
Status: WITHDRAWN
Conditions: Plaque Psoriasis
Interventions: DRUG: Acitretin (also called U0279)|DRUG: Placebo|BIOLOGICAL: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Preoperative CT Scan Guided and Intraoperative Hybrid DynaCT Scan-Guided Small Lung Tumor Localization
Status: COMPLETED
Conditions: Small and/or Deep Lung Tumor
Interventions: PROCEDURE: Hybrid Dyna-CT guided localization|PROCEDURE: Preoperative CT scan-guided localization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Speed of Processing Training to Improve Cognition in Traumatic Brain Injury and Mild Cognitive Impairment
Status: COMPLETED
Conditions: Traumatic Brain Injury|Mild Cognitive Impairment
Interventions: BEHAVIORAL: Speed of Processing Training|BEHAVIORAL: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Plasma Levels of Vascular Endothelial Growth Factor Before and After Intravitreal Injection of Aflibercept
Status: COMPLETED
Conditions: Exudative Age-related Macular Degeneration
Interventions: PROCEDURE: intravitreal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Safety, Tolerability and Pharmacokinetics of NRX-1074 in Normal Healthy Volunteers
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Placebo|DRUG: NRX-1074 375 mg|DRUG: NRX-1074 500 mg|DRUG: NRX-1074 750 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Manual Lymphatic Drainage Before and After Total Knee Replacement, a Single-center Observer-blinded Randomized Controlled Trial
Status: COMPLETED
Conditions: Total Knee Arthroplasty|Manual Lymphatic Drainage|MLD|Rehabilitation|Knee Osteoarthritis
Interventions: PROCEDURE: Manual Lymphatic Drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RO4929097 and Vismodegib in Treating Patients With Breast Cancer That is Metastatic or Cannot Be Removed By Surgery
Status: TERMINATED
Conditions: Estrogen Receptor Negative|HER2/Neu Negative|Progesterone Receptor Negative|Recurrent Breast Carcinoma|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer|Triple-Negative Breast Carcinoma
Interventions: DRUG: Gamma-Secretase Inhibitor RO4929097|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacogenomic Study|OTHER: Pharmacological Study|DRUG: Vismodegib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of VIB4920 in Participants With Sjögren's Syndrome
Status: COMPLETED
Conditions: Sjögren's Syndrome
Interventions: DRUG: VIB4920|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Coronary Heart Disease in Morbidly Obese Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Morbid Obesity|Hypertension|Type 2 DM|Obstructive Sleep Apnea|Osteoarthrosis
Interventions: PROCEDURE: Bariatric Surgery|BEHAVIORAL: Conservative Treatment:
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Probiotics and the Gut Brain Axis- Do Probiotics Interact With the Vagal Nerve?
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DIETARY_SUPPLEMENT: Multispecies-Probiotic|DIETARY_SUPPLEMENT: Placebo Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Evaluating the Safety and Efficacy of BEAM-201 in Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LL)
Status: RECRUITING
Conditions: Lymphoblastic Lymphoma|T-Cell Lymphoblastic Leukemia/Lymphoma|Lymphoblastic Leukemia
Interventions: BIOLOGICAL: BEAM-201
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: G-Eye Advanced Colonoscopy For Increased Polyp Detection Rate-randomized Tandem Study With Different Endoscopist
Status: COMPLETED
Conditions: Colorectal Cancer|Adenoma
Interventions: PROCEDURE: Standard Colonoscopy|PROCEDURE: G-EYE(TM) Colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Safety, Pk and Anti-inflammatory Effects of CC10 Protein in Premature Infants With Respiratory Distress Syndrome (RDS)
Status: COMPLETED
Conditions: Respiratory Distress Syndrome in Premature Infant|Bronchopulmonary Dysplasia
Interventions: DRUG: recombinant human CC10 (rhCC10)|DRUG: recombinant human CC10 (rhCC10)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Boosting Infant Resilience and Development
Status: NOT_YET_RECRUITING
Conditions: Child Maltreatment
Interventions: BEHAVIORAL: Attachment and Biobehavioral Catch-up (ABC10)|BEHAVIORAL: Attachment and Biobehavioral Catch-up, Brief (ABC3)|BEHAVIORAL: Safe Environment for Every Kid (SEEK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Umbralisib and Pembrolizumab in Treating Patients With Relapsed or Refractory Classical Hodgkin Lymphoma
Status: TERMINATED
Conditions: Hodgkin's Lymphoma
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Umbralisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Patient-Centered Counseling to Reduce Inappropriate Diagnostic Tests
Status: COMPLETED
Conditions: Unnecessary Procedures|Low Back Pain|Osteoporosis|Headache|Magnetic Resonance Imaging|Primary Care
Interventions: BEHAVIORAL: Standardized Patient Instructor Intervention|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Graduated Compression Stockings (GCS) Pilot Substudy
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DEVICE: Anti-Embolism Graduated Pressure Stockings (by BSN-Jobst)|DEVICE: No Graduated Compression Stockings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunomodulatory Profile of Dexmedetomidine Sedation in Patients Recovering After ARDS Covid-19
Status: UNKNOWN
Conditions: SARS-CoV 2
Interventions: OTHER: Inflammatory cytokines and chemokines profiles of patients with dexmedetomidine administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Demonstrate Equivalent Efficacy and to Compare Safety of Biosimilar Etanercept (GP2015) and Enbrel
Status: COMPLETED
Conditions: Chronic Stable Plaque Psoriasis
Interventions: DRUG: GP2015 Etanercept|DRUG: Enbrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ischemia In Hemodialysed Patients: Ivabradine Versus Carvedilol
Status: UNKNOWN
Conditions: Coronary Heart Disease|Angina|Hemodialysis
Interventions: DRUG: Ivabradine|DRUG: Carvedilol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ARO-C3 in Adult Healthy Volunteers and Patients With Complement Mediated Renal Disease
Status: RECRUITING
Conditions: C3 Glomerulopathy|IgA Nephropathy
Interventions: DRUG: ARO-C3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Asthma With Levocetirizine 18 Month Treatment in Infants (12 - 24 Months) Suffering From Eczema (Atopic Dermatitis) and Sensitized to Grass Pollen and/or House Dust Mite (HDM)
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: Placebo|DRUG: Levocetirizine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pioglitazone Therapy in Obese Children With Insulin Resistance: A Randomized, Controlled Pilot Study
Status: WITHDRAWN
Conditions: Obesity|Insulin Resistance
Interventions: DRUG: pioglitazone|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability and Preliminary Efficacy Study of BBI-4000 in Subjects With Axillary Hyperhidrosis
Status: COMPLETED
Conditions: Hyperhidrosis
Interventions: DRUG: BBI-4000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: E2 and LDX for the Treatment of Cognitive Complaints After Oophorectomy
Status: WITHDRAWN
Conditions: Planned RRSO
Interventions: DRUG: Lisdexamfetamine|DRUG: Estradiol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study on the Fecal Microbiota Transplantation in the Treatment of Ulcerative Colitis With Depression
Status: UNKNOWN
Conditions: Ulcerative Colitis
Interventions: DRUG: Intestinal flora capsule|PROCEDURE: placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrapleural Methylprednisolone Injection for Multiple Organ Failure With Acute Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome (ARDS)|Multiple Organ Failure
Interventions: DRUG: conventional ECMO with intravenous steroid|DRUG: solumedrol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of p38 Inhibitor AZD7624 in Corticosteroid Resistant Asthma
Status: COMPLETED
Conditions: Corticosteroid Resistant (CR) Asthmatics
Interventions: DRUG: AZD7624|DRUG: prednisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pomalidomide in Patients With Myeloproliferative Neoplasms in Fibrotic Stage
Status: COMPLETED
Conditions: Myeloproliferative Neoplasms
Interventions: DRUG: Pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HELicobacter Pylori Screening to Prevent Gastrointestinal Bleeding in MI Patients
Status: RECRUITING
Conditions: Myocardial Infarction|Helicobacter Pylori Infection|GastroIntestinal Bleeding|Cardiovascular Diseases
Interventions: DIAGNOSTIC_TEST: Urea breath test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Biological Effect of ESWT and the Role of Proinflammatory Cytokines and Cannabinoid Receptor in Shoulder Stiffness
Status: UNKNOWN
Conditions: Stiffness of Shoulder, Not Elsewhere Classified
Interventions: OTHER: ESWT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Single Oral Dose Study to Compare the Bioavailability Between Two Different Tablet Formulations and Assess if There is a Food Effect With the New Formulation
Status: COMPLETED
Conditions: Pharmacokinetics of ASP015K|Bioavailability of ASP015K|Healthy Subjects
Interventions: DRUG: ASP015K
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: ZNN Bactiguard Cephalomedullary Nails PMCF Study
Status: RECRUITING
Conditions: Osteotomy|Trochanteric Fractures|Sub-trochanteric Fractures|Femoral Shaft Fracture
Interventions: PROCEDURE: Fracture fixation via Intramedullary Nailing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Desflurane Versus Propofol on Hemostasis During Splenectomy
Status: COMPLETED
Conditions: Status; Splenectomy
Interventions: DRUG: Desflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rapid HIV Treatment Initiation, Access and Engagement in Care
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: Dolutegravir 50 MG|DRUG: Emtricitabine/Tenofovir Alafenamide 200 MG-25 MG Oral Tablet [DESCOVY]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paricalcitol, Fluorouracil, and Radiation Therapy in Treating Patients With Rectal Cancer That Can Be Removed in Surgery
Status: TERMINATED
Conditions: Mucinous Adenocarcinoma of the Rectum|Stage IIA Rectal Cancer|Stage IIB Rectal Cancer|Stage IIC Rectal Cancer|Stage IIIB Rectal Cancer|Stage IIIC Rectal Cancer
Interventions: DRUG: paricalcitol|RADIATION: radiation therapy|OTHER: laboratory biomarker analysis|DRUG: fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COrticosteroids in acUte uRticAria in emerGency dEpartment
Status: RECRUITING
Conditions: Urticaria|Angiœdema
Interventions: DRUG: Placebo Oral Tablet|DRUG: Cortancyl Oral Tablet|DRUG: Levocetirizine Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Physical Form of Apples on Gastrointestinal Function and Satiety: a MRI Study
Status: COMPLETED
Conditions: Gastrointestinal Symptoms
Interventions: OTHER: Whole apples|OTHER: Apple puree|OTHER: Apple Juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Arnold Chiari Malformation: the Otological Assessment as an Objective Criteria for Surgical Treatment
Status: COMPLETED
Conditions: Arnold-Chiari Malformation, Type 1
Interventions: DIAGNOSTIC_TEST: Multifrequency tympanometry at Inclusion|DIAGNOSTIC_TEST: Multifrequency tympanometry 6 month after surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Vaccine (MV-s-NAP) for the Treatment of Patients With Invasive Metastatic Breast Cancer
Status: RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Invasive Breast Carcinoma|Metastatic Breast Adenocarcinoma|Recurrent Breast Carcinoma
Interventions: BIOLOGICAL: Oncolytic Measles Virus Encoding Helicobacter pylori Neutrophil-activating Protein
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Skin Conductance Algesimeter and the Nociception Level Index in the Paediatric Population. An Observational Study.
Status: RECRUITING
Conditions: Nociceptive Pain|Anesthesia|Pain
Interventions: DEVICE: Connecting patients to both non-invasive monitors to observe and compare the monitor's capabilities.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety of a Herpes Simplex Candidate Vaccine (gD2t) With MPL and Its Efficacy to Prevent Genital Herpes Disease
Status: COMPLETED
Conditions: Herpes Simplex
Interventions: BIOLOGICAL: Herpes simplex candidate vaccine- adjuvanted GSK208141|BIOLOGICAL: Placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating the Efficacy and Safety of JCAR015 in Adult B-cell Acute Lymphoblastic Leukemia (B-ALL)
Status: TERMINATED
Conditions: Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: JCAR015 (CD19-targeted CAR T cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sargramostim Use in COVID-19 to Recover Patient Health
Status: COMPLETED
Conditions: Covid19|SARS-CoV Infection
Interventions: DRUG: Sargramostim|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing the Efficacy of MEK162 Versus Dacarbazine in Unresectable or Metastatic NRAS Mutation-positive Melanoma
Status: COMPLETED
Conditions: Metastatic or Unresectable Cutaneous Melanoma
Interventions: DRUG: MEK162|DRUG: Dacarbazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Epirubicin, Cisplatin and Capecitabine (ECX) Versus Cisplatin and Capecitabine (CX) for Advanced Gastric Cancer (AGC)
Status: COMPLETED
Conditions: Advanced Gastric Cancer
Interventions: DRUG: Epirubicin|DRUG: Cisplatin, capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Azithromycin on Lung Function in 6-18 Year-olds With Cystic Fibrosis (CF) Not Infected With P. Aeruginosa
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: azithromycin 250 mg tablets|DRUG: placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modafinil Effects on Cognition in Schizophrenia Patients
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: modafinil (M1, M2, M4)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ICIs Neoadjuvant Therapy in Resectable Non-Small-Cell Lung Cancer
Status: COMPLETED
Conditions: High-Risk Resectable NSCLC
Interventions: DRUG: Nivolumab, Pembrolizumab, Toripalimab, Sintilimab, Sintilimab, Tislelizumab, Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Nitrogen Mustard in Treatment of Mycosis Fungoides
Status: COMPLETED
Conditions: Mycosis Fungoides
Interventions: DRUG: mechlorethamine-MCH (nitrogen mustard)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Developing and Testing a COVID-19 Vaccination Acceptance Intervention
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19 Vaccination
Interventions: BEHAVIORAL: Moving to COVID-19 Vaccine Acceptance Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Investigation of Oral OKN-007 in Recurrent High-grade Glioma Participants
Status: WITHDRAWN
Conditions: Glioblastoma|Astrocytoma|Oligodendroglioma
Interventions: DRUG: OKN-007
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of ZK 6032924 in Probable Alzheimer's Disease Patients Versus Healthy Volunteers and the Radiation Dosimetry of ZK 6032924 in Healthy Volunteers
Status: COMPLETED
Conditions: Positron-Emission Tomography|Alzheimer's Disease
Interventions: DRUG: F-18 FEDAA1106 (BAY85-8101)|DRUG: F-18 FEDAA1106 (BAY85-8101)|DRUG: F-18 FEDAA1106 (BAY85-8101)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC