pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Nebulized Versus Intravenous Dexmedetomidine for Sevoflurane Induced Emergence Agitation After Pediatric Tonsillectomy
Status: RECRUITING
Conditions: Emergence Agitation
Interventions: DRUG: Nebulized Dexmedetomidine|DRUG: Intravenous Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II Study of Treatment for HPV16+ ASC-US, ASC-H and LSIL
Status: TERMINATED
Conditions: ASC-US|ASC-H|LSIL
Interventions: BIOLOGICAL: PVX-2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Cardiac Shock Wave Therapy (CSWT) for Treatment of Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: cardiac shock wave therapy(CSWT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Extension Trial of Tildrakizumab to Prove Its Safety in Subjects With Psoriatic Arthritis Who Have Previously Completed Study With Tildrakizumab.
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: SUNPG18_07 I|DRUG: SUNPG18_07 II|DRUG: SUNPG18_07 III
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Cooperative Education Program Based on Precede-Proceed Model During Pregnancy on Postpartum Depression
Status: UNKNOWN
Conditions: Post Partum Depression
Interventions: BEHAVIORAL: Cooperative Education Program based on Precede-Proceed Model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Metabolic and Cardiovascular Effects of Armolipid Plus in Subjects With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome|Insulin-resistance|Left Ventricular Hypertrophy
Interventions: DIETARY_SUPPLEMENT: Armolipid Plus|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Older Patients With Intermediate- or High-Grade Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: mitoxantrone hydrochloride|DRUG: prednisolone|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Circaid® Compression Sleeve Versus Short-stretching Bandage in Upper Limb Lymphatic Edema
Status: COMPLETED
Conditions: Lymphedema of Upper Arm
Interventions: DEVICE: Circaid|DEVICE: Short-stretching Bandage (Reference treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase IV Clinical Study of Pegylated Somatropin (PEG Somatropin) to Treat Growth Hormone Deficiency Children
Status: UNKNOWN
Conditions: Dwarfism, Pituitary
Interventions: BIOLOGICAL: PEG-somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective, Randomized Clinical Trial Evaluating the ETView Double-Lumen Tube
Status: COMPLETED
Conditions: Patients Undergoing Elective Thoracic Surgery Requiring Obligatory Single-lung Ventilation During Surgery
Interventions: DEVICE: ET View Double Lumen Tube|DEVICE: conventional Double Lumen Tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Gum Arabic on Gastrointestinal Transit and Permeability
Status: COMPLETED
Conditions: Diverticulitis
Interventions: DIETARY_SUPPLEMENT: High-dose prebiotic|DIETARY_SUPPLEMENT: Low-dose prebiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Optimizing (Longer, Deeper) Cooling for Neonatal Hypoxic-Ischemic Encephalopathy(HIE)
Status: TERMINATED
Conditions: Infant, Newborn|Hypoxia, Brain|Hypoxia-Ischemia, Brain|Encephalopathy, Hypoxic-Ischemic|Hypoxic-Ischemic Encephalopathy|Ischemic-Hypoxic Encephalopathy
Interventions: PROCEDURE: Whole-body Cooling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Escoge Salud (Choose Health): a Chronic Pain Self-Management Program in Middle to Older Age Hispanic Americans
Status: COMPLETED
Conditions: Chronic Pain
Interventions: BEHAVIORAL: Chronic Disease Self-Management Program (CDSMP) for chronic pain in Spanish|BEHAVIORAL: Remote feedback active group|BEHAVIORAL: Remote feedback control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Rehabilitation Exercise on the Non-operative Limb Following Anterior Cruciate Ligament Reconstruction
Status: COMPLETED
Conditions: Musculoskeletal System
Interventions: OTHER: Contralateral Rehabilitation|OTHER: Placebo flexibility exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Field Study of Health Worker Training on Helping Mothers Survive Module 'Essential Care for Labor & Birth' in Zanzibar
Status: COMPLETED
Conditions: Parturition
Interventions: OTHER: HMS EL&C training module|OTHER: Videos used to supplement live trainer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of Evacetrapib (LY2484595) and Warfarin in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Evacetrapib|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Celecoxib in Preventing Skin Cancer in Patients With Actinic Keratoses
Status: WITHDRAWN
Conditions: Precancerous Condition
Interventions: DRUG: celecoxib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy/Safety of Meropenem-Vaborbactam Compared to Piperacillin-Tazobactam in Adults With cUTI and AP
Status: COMPLETED
Conditions: Urinary Tract Infection Complicated|Acute Pyelonephritis
Interventions: DRUG: Meropenem-Vaborbactam|DRUG: Piperacillin-Tazobactam|DRUG: Levofloxacin|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Placebo-Controlled Trial of D-Cycloserine and Exposure Therapy for Combat-PTSD
Status: COMPLETED
Conditions: Combat Disorders|Stress Disorders, Post-Traumatic
Interventions: BEHAVIORAL: Exposure therapy|DRUG: D-Cycloserine|OTHER: Placebo pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Safety & Tolerability of OPC-34712 as Adjunctive Therapy in Treatment of Adult Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: ADT|DRUG: OPC-34712
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of RYZ101 Compared With SOC in Pts w Inoperable SSTR+ Well-differentiated GEP-NET That Has Progressed Following 177Lu-SSA Therapy
Status: RECRUITING
Conditions: GEP-NET|Gastroenteropancreatic Neuroendocrine Tumor|Gastroenteropancreatic Neuroendocrine Tumor Disease|Neuroendocrine Tumors|Carcinoid|Carcinoid Tumor|Pancreatic NET
Interventions: DRUG: RYZ101|DRUG: Everolimus|DRUG: Sunitinib|DRUG: Octreotide|DRUG: Lanreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ex Vivo Drug Sensitivity Testing and Mutation Profiling
Status: COMPLETED
Conditions: Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Large Cell Lymphoma|Refractory Childhood Acute Lymphoblastic Leukemia|Refractory Childhood Hodgkin Lymphoma|Refractory Childhood Malignant Germ Cell Neoplasm|Recurrent Childhood Brain Tumor|Recurrent Childhood Brainstem Glioma|Recurrent Childhood Rhabdomyosarcoma|Recurrent Childhood Soft Tissue Sarcoma|Recurrent Childhood Ependymoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Gliosarcoma|Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Dorzagliatin on Renal Function Outcomes in People With Type 2 Diabetes: a Multicentric, Prospective, Randomized Study.
Status: NOT_YET_RECRUITING
Conditions: Diabetic Nephropathy Type 2
Interventions: DRUG: Dorzagliatin|DRUG: Gliclazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Median Effective Dose of Cisatracurium for the Prevention of Fasciculation Caused by the Injection of Succinylcholine
Status: RECRUITING
Conditions: Fasciculation|Succinylcholine
Interventions: DRUG: Cisatracurium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Oral Nutritional Supplements to Older Patients Discharged With a Rehabilitation Plan
Status: RECRUITING
Conditions: Nutritional Risk|Rehabilitation|Oral Nutritional Supplements
Interventions: DIETARY_SUPPLEMENT: Protein omega-3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CSD1805: Study to Assess Nicotine Uptake and Product Use Behavior in Moist Snuff Consumers Using Two Moist Snuff Products
Status: COMPLETED
Conditions: Tobacco Use
Interventions: OTHER: 1805AA|OTHER: 1805AB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Drug-drug Interaction Study of Ozanimod With Pseudoephedrine to Evaluate the Effect on Blood Pressure and Heart Rate
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: ozanimod|DRUG: Pseudoephedrine|DRUG: ozanimod placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ultrasound Guided Cricoid and Paralaryngeal Pressure
Status: COMPLETED
Conditions: Ultrasonography, Interventional
Interventions: OTHER: paralaryngeal pressure|OTHER: cricoid pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Use of Construal Level Theory to Inform Messaging to Increase Vaccination Against COVID-19
Status: COMPLETED
Conditions: Covid19|Vaccine Refusal
Interventions: BEHAVIORAL: Messaging informed by construal level theory|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Extension Study To Evaluate The Long-Term Safety, Tolerability, And Efficacy Of Low And High Doses Of Bl-1020
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: BL-1020|DRUG: BL-1020 10-30 mg|DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Short-term Effects of Instrument-Based Mobilization Compared With Manual Mobilization for Low Back Pain: A Randomized ClinicalTrial
Status: UNKNOWN
Conditions: Low Back Pain, Mechanical
Interventions: OTHER: mobilization|OTHER: manual therapy|OTHER: instrumental manual therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Lipiflow Treatment to Reduce Pharmacologic Burden in DED
Status: ENROLLING_BY_INVITATION
Conditions: MGD-Meibomian Gland Dysfunction
Interventions: DEVICE: Thermal Vectored Pulsation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of GS-5745 in Subjects With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: GS-5745|DRUG: Placebo to match GS-5745
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapy With Hydrocortisone, Ascorbic Acid, Thamine in Patients With Sepsis
Status: COMPLETED
Conditions: Sepsis
Interventions: DRUG: Hydrocortisone, Ascorbic acid, Thiamine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Local Inflammation in Arrhythmogenic Right Ventricular Cardiomyopathy
Status: UNKNOWN
Conditions: Arrhythmogenic Right Ventricular Dysplasia
Interventions: BIOLOGICAL: Peripheral immunological assessment on venous blood|BIOLOGICAL: Immunological assessment carried out on intracardiac material
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Development of Applications of the Bravo® pH Monitoring System and Evaluation of Its Performance
Status: COMPLETED
Conditions: Gastro Esophageal Reflux Disease
Interventions: DEVICE: Bravo® pH Monitoring System|DEVICE: Bravo® pH Monitoring System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: TB Screening Improves Preventive Therapy Uptake
Status: ACTIVE_NOT_RECRUITING
Conditions: Tuberculosis|Latent Tuberculosis|Tuberculosis Prevention|HIV
Interventions: DEVICE: CRP, point-of-care assay
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Study of the Effect of Dapagliflozin on the Pharmacokinetics of Warfarin or Digoxin in Healthy Subjects
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Dapagliflozin|DRUG: Warfarin|DRUG: Digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melatonin in Relapsing-Remitting Multiple Sclerosis Patients
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Trial of Olanzapine in Outpatients With Pathological Gambling
Status: COMPLETED
Conditions: Pathological Gambling
Interventions: DRUG: olanzapine|DRUG: sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Massage in Different Moments of Application on Autonomic Cardiac Modulation and Cardiorespiratory Parameters
Status: UNKNOWN
Conditions: Healthy Volunteers
Interventions: OTHER: Massage|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Effectiveness and Safety of SD-101 in Participants With Epidermolysis Bullosa
Status: COMPLETED
Conditions: Epidermolysis Bullosa
Interventions: DRUG: SD-101 dermal cream (3%)|DRUG: SD-101 Dermal Cream (6%)|DRUG: Vehicle (SD-101 0%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: HoLEP Vs BPEP for Large Prostatic Adenoma
Status: COMPLETED
Conditions: Prostate Hyperplasia
Interventions: PROCEDURE: Holmium laser enucleation of the prostate versus bipolar transurethral enucleation of the prostate in management of benign prostatic hyperplasia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY900027 Given by Insulin Pump to Participants With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: LY900027|DRUG: Insulin Lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial to Learn if Dupilumab is Safe for and Helps Adult and Adolescent Participants With Eosinophilic Gastritis With or Without Eosinophilic Duodenitis
Status: RECRUITING
Conditions: Eosinophilic Gastritis|Eosinophilic Duodenitis|Eosinophilic Gastrointestinal Disease
Interventions: DRUG: Dupilumab Dose 1|DRUG: Dupilumab Dose 2|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness Study of Vilazodone to Treat Depression and to Discover Genetic Markers Associated With Response
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: vilazodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Trial of Silymarin for Chronic Liver Diseases
Status: COMPLETED
Conditions: Hepatitis C|Non-Alcoholic Fatty Liver Disease
Interventions: DRUG: Placebo|DRUG: Silymarin|DRUG: Silymarin|DRUG: Silymarin|DRUG: Silymarin|DRUG: Silymarin|DRUG: Silymarin|DRUG: Silymarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Excretion Balance of Radiocarbon and the Pharmacokinetics and Metabolic Profile of TRO19622 (Olesoxime)
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Olesoxime
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ursodiol on Insulin Sensitivity, Gastric Emptying and Body Weight With Type 2 Diabetes on Metformin
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Ursodiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Classical Healing Concept With the Complete Remission Concept After Treatment With Pantoprazole in Adult Patients With Erosive GERD (Gastroesophageal Reflux Disease) (BY1023/M3-342)
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: Pantoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Safety and Immunogenicity Trial of Live Recombinant Canarypox ALVAC-HIV (vCP205) and HIV-1 SF-2 rgp120 in HIV-1 Uninfected Volunteers to Evaluate Accelerated Vaccine Schedules
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: ALVAC-HIV MN120TMG (vCP205)|BIOLOGICAL: ALVAC-RG Rabies Glycoprotein (vCP65)|BIOLOGICAL: rgp120/HIV-1 SF-2
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Transcranial Current Stimulation as a Treatment for Auditory Hallucinations in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Auditory Hallucinations
Interventions: DEVICE: tDCS|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cyclophosphamide as Sole Graft-Versus-Host-Prophylaxis After Allogeneic Stem Cell Transplantation
Status: COMPLETED
Conditions: Multiple Myeloma|Non-Hodgkin-Lymphoma|Hodgkin's Disease
Interventions: DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Optimal Postoperative Chest Tube and Pain Management in Patients Surgically Treated for Primary Spontaneous Pneumothorax (Pneumotrial)
Status: RECRUITING
Conditions: Pneumothorax, Primary Spontaneous|VATS|Pain, Postoperative|Locoregional Anaesthesia|Thoracic Epidural|Chest Tube Drainage
Interventions: PROCEDURE: Thoracic epidural analgesia|PROCEDURE: Single-shot paravertebral block|PROCEDURE: Late chest tube removal|PROCEDURE: Early chest tube removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GYNecological Cancers Treated With NETrin mAbs in Combination With Chemotherapy and /or Pembrolizumab
Status: RECRUITING
Conditions: Endometrial Carcinoma|Cervix Carcinoma
Interventions: DRUG: NP137|DRUG: Pembrolizumab|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of Intravenous Aflibercept in Combination With S-1 in Japanese Cancer Patients
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: aflibercept (AVE0005)|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Sildenafil for Fontan Associated Liver Disease (SiFALD) Study
Status: COMPLETED
Conditions: Cirrhosis|Congenital Heart Disease
Interventions: DRUG: Sildenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Randomized, Double-blind, Placebo-controlled Study in Patients With Fistulizing Crohn's Disease
Status: COMPLETED
Conditions: Fistulizing Crohn's Disease
Interventions: DRUG: DLX105|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Electrical Stimulation (NMES) and Muscle Protein Accretion (ES-PRO)
Status: COMPLETED
Conditions: Sarcopenia
Interventions: DEVICE: Enraf Nonius Tensmed S84 for Neuromuscular electrical stimulation (NMES)|DEVICE: No Enraf Nonius Tensmed S84 for Neuromuscular electrical stimulation (NMES) NMES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Valproic Acid in Combination With Bevacizumab and Oxaliplatin/Fluoropyrimidine Regimens in Patients With Ras-mutated Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Ras-mutated Metastatic Colorectal Cancer
Interventions: DRUG: Bevacizumab|DRUG: mFOLFOX6 regimen|DRUG: mOXXEL regimen|DRUG: Valproic acid|DRUG: Capecitabine|DRUG: 5-fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of AloCelyvir in Patients With Metastatic Uveal Melanoma
Status: NOT_YET_RECRUITING
Conditions: Uveal Melanoma, Metastatic
Interventions: BIOLOGICAL: AloCelyvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: One-Lung Ventilation in the Morbidly Obese Patient: Comparison of Double Lumen Versus Bronchial Blockers
Status: COMPLETED
Conditions: Obesity
Interventions: DEVICE: Double Lumen Endotracheal Tube|DEVICE: Arndt Bronchial Blocker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Heart Control at Different Stages in Patients of Septic Shock With Tachycardia
Status: UNKNOWN
Conditions: Septic Shock|Tachycardia
Interventions: DRUG: Esmolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine Intraperitoneal,Tissue, Serum Concentrations of VML-0501 Following Five Days of Daily Vaginal Single Dose of VML-0501 (100 mg Danazol), in Comparison to Oral Danazol Capsules Daily 600 mg), in Women With Signs and Symptoms of Endometriosis Undergoing Laparoscopy
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: Vaginal Danazol|DRUG: Oral Danatrol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Three Dose Regimen of Tranexamic Acid in Cardiac Surgery
Status: UNKNOWN
Conditions: Hemostasis
Interventions: DRUG: Tranexamic Acid|DRUG: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Bevacizumab (Avastin) With Thoracic Radiation in Non-small Cell Cell Lung Cancer
Status: TERMINATED
Conditions: Toxicity
Interventions: BIOLOGICAL: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Pharmacokinetics of GDC-8264 in Combination With Standard of Care in Participants With Acute Graft-Versus-Host Disease (aGVHD)
Status: TERMINATED
Conditions: Acute Graft-versus-host Disease
Interventions: DRUG: GDC-8264
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety and Efficacy of TQB2618 Injection Combined With Penpulimab in the Treatment of Patients With Relapsed and Refractory Lymphoma
Status: UNKNOWN
Conditions: Relapsed/Refractory Lymphoma
Interventions: DRUG: TQB2618 injection|DRUG: Penpulimab injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of SHR4640 Tablets Combined With Febuxostat Tablets in the Treatment of Primary Gout and Hyperuricemia
Status: UNKNOWN
Conditions: Primary Gout and Hyperuricemia
Interventions: DRUG: SHR4640 tablet|DRUG: SHR4640 tablet|DRUG: febuxostat tablet|DRUG: SHR4640 placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), Food Effect of AMG 357 in Healthy Subjects
Status: COMPLETED
Conditions: Inflammatory Disease
Interventions: DRUG: AMG 357|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 10°C vs 4°C Lung Preservation RCT
Status: RECRUITING
Conditions: Lung Transplant|Organ Preservation
Interventions: DEVICE: Lung transplantation after 10°C donor lung preservation|DEVICE: Lung transplantation after standard ice cooler donor lung preservation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety Study of Rikkunshito in Patients With Functional Dyspepsia
Status: COMPLETED
Conditions: Functional Dyspepsia
Interventions: DRUG: Rikkunshito|DRUG: Rikkunshito placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anxiety and Depression in Patients Hospitalizes for an Acute Exacerbation of COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Anxiety|Depression
Interventions: BEHAVIORAL: Counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Transforming Opioid Prescribing in Primary Care
Status: COMPLETED
Conditions: Chronic Pain|Opioid-Related Disorders
Interventions: BEHAVIORAL: Electronic decision support tools|BEHAVIORAL: Enhanced patient education materials|BEHAVIORAL: Nurse care management|BEHAVIORAL: Electronic Patient Registry|BEHAVIORAL: Academic detailing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Plaque and Gingivitis Evaluation of a U-Shaped Toothbrush in a 30-Day Model
Status: COMPLETED
Conditions: Plaque Induced Gingivitis
Interventions: DEVICE: U-shaped Power Toothbrush|DEVICE: Soft Manual Toothbrush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Performance Study of the ARGOS-IO System in Patients Undergoing Boston Keratoprosthesis Implantation
Status: COMPLETED
Conditions: Graft vs Host Disease|Congenital Aniridia|Chemical Burns|Stevens-Johnson Syndrome|Congenital Glaucoma
Interventions: DEVICE: ARGOS-IO system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Efficacy of Amnion Chorion Allograft in Management of Gingival Recession.
Status: NOT_YET_RECRUITING
Conditions: Gingival Recession, Localized
Interventions: BIOLOGICAL: Amnion Chorion membrane|PROCEDURE: connective tissue graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: INRT-AIR: A Prospective Phase II Study of Involved Nodal Radiation Therapy
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: RADIATION: Intensity modulated radiation therapy (IMRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platinum and Polyadenosine 5'Diphosphoribose Polymerisation Inhibitor for Neoadjuvant Treatment of Triple Negative Breast Cancer and/or Germline BRCA Positive Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Olaparib|DRUG: Paclitaxel and Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study in Patients With Chronic Kidney Disease and Hyperphosphatemia on Peritoneal Dialysis
Status: COMPLETED
Conditions: Chronic Kidney Disease|Renal Dialysis|Renal Insufficiency
Interventions: DRUG: ASP1585
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I, Randomized, Modified Single-blind, Active-controlled (Infants Only), Four-stage, Step-down, Comparative, Multi-center Study
Status: COMPLETED
Conditions: Meningococcal Immunization
Interventions: BIOLOGICAL: Meningococcal (Groups A, C, Y and W-135) Polysaccharide Tetanus Protein Conjugate Vaccine (TetraMen-T).|BIOLOGICAL: Meningococcal Group C-CRM197 Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Booster With 1 or 2 Doses of HAV Vaccine Among HIV-infected Patients
Status: COMPLETED
Conditions: Hepatitis A|Human Immunodeficiency Virus|Vaccine Response Impaired
Interventions: DRUG: Vaqta Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Cinitapride Tablets in the Treatment of Mild to Moderate Functional Dyspepsia
Status: COMPLETED
Conditions: Dyspepsia
Interventions: DRUG: Cinitapride|DRUG: domperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study: Effect of 25(OH)D and Vitamin D3 on Serum 25(OH)D
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 25(OH)D|DIETARY_SUPPLEMENT: vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Thermosensitive Hydroxybutyl Chitosan and 5-fluorouracil Assisted Endoscopic Dacryocystorhinostomy in the Treatment of Chronic Dacryocystitis
Status: COMPLETED
Conditions: Dacryocystorhinostomy|Hydroxybutyl Chitosan|Fluorouracil|Chronic Dacryocystitis
Interventions: DRUG: Hydroxybutyl chitosan|DRUG: 5-Fluorouracil|DRUG: Gelatin Sponge Sheet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing BoneMaster Hydroxyapatite Coating With Plasma-sprayed Hydroxyapatite Coating on Acetabular Cups
Status: COMPLETED
Conditions: Arthropathy of Hip
Interventions: DEVICE: BoneMaster coated acetabular shell.|DEVICE: Plasma Coated Acetabular Shell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sanchitongtshu Plus Asprine for Minor Ischemic Stroke or Transient Ischemic Attack: A Randomized Double-blind Study
Status: UNKNOWN
Conditions: Stroke, Acute|Ischemic Attack, Transient
Interventions: DRUG: Sanchitongshu|DRUG: placebo of Sanchitongshu|DRUG: Aspirin|DRUG: Clopidogrel|DRUG: placebo of clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Breastfeeding Promotion in Lebanon Through a Salutogenic Intervention
Status: COMPLETED
Conditions: Breast Feeding|Exclusive Breastfeeding|Salutogenesis
Interventions: BEHAVIORAL: Videos with breastfeeding education material and encouraging messages|BEHAVIORAL: Whatsapp group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cilengitide Together With Radiochemotherapy in Patients With Locally Advanced Non Small Cell Lung Cancer
Status: COMPLETED
Conditions: Locally Advanced Non Small Cell Lung Cancer (NSCLC)
Interventions: DRUG: cilengitide, radiochemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Concentration and Volume on Adequate Labor Analgesia With PIEB
Status: TERMINATED
Conditions: Pain|Anesthesia|Labor Pain
Interventions: DRUG: Low volume bolus|DRUG: High volume bolus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness and Relaxation Interventions in Individual Psychotherapies for Children and Adolescents
Status: UNKNOWN
Conditions: Hyperkinetic Disorder|Depressive Disorder|Anxiety Disorder
Interventions: BEHAVIORAL: Cognitive behavior therapy of trainee therapists
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Synthetic Cartilage Implant vs Osteochondral Autograft Transfer for Advanced 1st Metatarsal Phalangeal Joint Arthritis
Status: WITHDRAWN
Conditions: Metatarsophalangeal Joint Arthritis
Interventions: DEVICE: Synthetic Cartilage Implant|PROCEDURE: Osteochondral Autograft Transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Subcutaneous Abatacept in Adults With Active Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Abatacept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy and Safety of Ustekinumab Re-induction Therapy in Participants With Moderately to Severely Active Crohn's Disease
Status: COMPLETED
Conditions: Crohn Disease
Interventions: DRUG: Ustekinumab approximately 6 mg/kg (IV)|DRUG: Placebo (SC)|DRUG: Placebo (IV)|DRUG: Ustekinumab 90 mg (SC) Group 1|DRUG: Ustekinumab 90 mg (SC) Group 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Assessment of Clinical Utility PET / MR With the Use of the Radiotracer 68Ga-PSMA-11 in Therapy Planning Personalized in Patients With Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: Radiopharmaceutical 68Ga-PSMA-11 PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metabolic Effects of Chronic Ketosis (KETO-CHF Metabolic)
Status: COMPLETED
Conditions: Heart Failure
Interventions: DIETARY_SUPPLEMENT: Ketone monoester|DIETARY_SUPPLEMENT: Placebo drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TracPatch in Total Knee Arthroplasty
Status: ACTIVE_NOT_RECRUITING
Conditions: Arthroplasty, Replacement, Knee|Osteoarthritis, Knee
Interventions: DEVICE: Consensus TracPatch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Different Altitude Levels on Spinal Anesthesia in Cesarean Section Surgery
Status: COMPLETED
Conditions: Pregnant|High Altitude
Interventions: PROCEDURE: cesarian surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Low-Fat Fish Oil Diet for Prostate Cancer Prevention
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: Fish Oil|DIETARY_SUPPLEMENT: Vitamin E supplement|DIETARY_SUPPLEMENT: Western Diet|DIETARY_SUPPLEMENT: Low-Fat Diet|OTHER: Medical Examination|OTHER: Dietary Interview|OTHER: Blood Draw|PROCEDURE: Radical Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Higher Albendazole and Ivermectin Doses on Wuchereria Bancrofti Microfilarial Clearance in Malawi
Status: TERMINATED
Conditions: Lymphatic Filariasis
Interventions: DRUG: Albendazole 400mg and ivermectin 200mcg/kg|DRUG: Albendazole and ivermectin|DRUG: Albendazole 400mg and ivermectin 200mcg/kg|DRUG: albendazole 800mg and ivermectin 400mcg/kg bi-annually
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effects of Co-Administration of Sitagliptin (MK-0431) and Metformin on Incretin Hormone Concentrations (MK-0431-110)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: sitagliptin phosphate|DRUG: metformin hydrochloride|DRUG: Comparator: placebo sitagliptin|DRUG: Comparator: placebo metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quality of Life and Psychological Vulnerability in Patients With RH+ Metastatic Breast Cancer
Status: TERMINATED
Conditions: Metastatic Breast Cancer|Positive Hormonal Receptors
Interventions: OTHER: Quality of life in metastatic BC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Feasibility of Using a Smart Phone Application for Self-titration of Insulin on Glycemic Control in Patients With T2DM
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: Smart phone application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cryoneurolysis Prior to Total Knee Arthroplasty
Status: RECRUITING
Conditions: Post Operative Pain|Knee Osteoarthritis|Opioid-Related Disorders
Interventions: DEVICE: Cryoneurolysis|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Genetically Engineered Cells (EGFRt/19-28z/IL-12 CAR T Cells) for the Treatment of Relapsed or Refractory CD19+ Hematologic Malignancies
Status: RECRUITING
Conditions: Recurrent Chronic Lymphocytic Leukemia|Recurrent Diffuse Large B-Cell Lymphoma|Recurrent Follicular Lymphoma|Recurrent High Grade B-Cell Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Transformed Chronic Lymphocytic Leukemia|Recurrent Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Diffuse Large B-Cell Lymphoma|Refractory Follicular Lymphoma|Refractory High Grade B-Cell Lymphoma|Refractory Mantle Cell Lymphoma|Refractory Transformed Chronic Lymphocytic Leukemia|Refractory Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Computed Tomography|DRUG: Cyclophosphamide|PROCEDURE: Echocardiography|BIOLOGICAL: EGFRt/19-28z/IL-12 CAR T-lymphocytes|DRUG: Fludarabine Phosphate|PROCEDURE: Leukapheresis|PROCEDURE: Multigated Acquisition Scan|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Image-guided Focal Brachytherapy Utilizing Combined 18F-DCFPyl PET/CT
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: Focal brachytherapy with PSMA PET imaging|DRUG: (18F)DCFPyL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PECI/SPB vs Intercostal Nerve Block for the Management of Postoperative Pain in Latissimus Dorsi Flap Reconstruction
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: PROCEDURE: PECI/SPB Block with Active Anesthetic + Placebo Multilevel Intercostal Nerve Block followed by Latissimus Dorsi Flap Breast Reconstruction|PROCEDURE: Placebo PEC/SPB Block + Multilevel Intercostal Nerve Block with Active Anesthetic followed by Latissimus Dorsi Flap Breast Reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: In Home Assessment of Three Anti-Snoring Devices, a Cross Over Study
Status: COMPLETED
Conditions: Snoring
Interventions: DEVICE: Nasal Dilator|DEVICE: Mandibular Advancement|DEVICE: Positional Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Trial of Daily Chlorhexidine Bathing to Reduce Nosocomial Infections
Status: UNKNOWN
Conditions: Nosocomial Bacteremia|MRSA Colonization|MRSA Infection|VRE Colonization|VRE Infection
Interventions: PROCEDURE: Bathing with Chlorhexidine Impregnated Washcloths
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Laser-assisted Topical Administration of Etanercept (Enbrel®) in Patients With Mild to Moderate Plaque-type Psoriasis
Status: UNKNOWN
Conditions: Psoriatic Plaque
Interventions: DEVICE: Laser microporation alone|DRUG: Standard of care-daily administration of Daivobet|DRUG: Laser microporation + topical application of Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Blood Pressure Control During Cancer Treatment
Status: RECRUITING
Conditions: Breast Cancer|Cardiotoxicity
Interventions: OTHER: antihypertensive medications|DIAGNOSTIC_TEST: Blood pressure measurement|DIAGNOSTIC_TEST: Echocardiogram|OTHER: Symptom-limited cardiopulmonary exercise test|OTHER: Quality of Life Measures|DIAGNOSTIC_TEST: Biomarkers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Hematologic Profile, Vit. B12 and Folic Acid in Cirrhotics Received Sofosbuvir and Daclatasvir With or Without Ribavirin
Status: COMPLETED
Conditions: Liver Cirrhoses|Chronic Hepatitis c|Directly Acting Antivirals
Interventions: DIAGNOSTIC_TEST: Vitamin B12 and Folic Acid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p