pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparison of Lobeglitazone With Pioglitazone as Initial Triple Therapy for Diabetes Management
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: Pioglitazone|DRUG: Lobeglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PrEP Readiness Interventions for Supporting Motivation
Status: COMPLETED
Conditions: HIV Infections|Pre-exposure Prophylaxis|Substance Use Disorders
Interventions: BEHAVIORAL: Motivational Interviewing (MI)|BEHAVIORAL: Contingency Management (CM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of a Starter Formula With Synbiotics on Stool Microbiota in Infants After Normal or Caesarean Section Delivery
Status: TERMINATED
Conditions: Healthy Full Term Infants
Interventions: DIETARY_SUPPLEMENT: formula with synbiotics|DIETARY_SUPPLEMENT: formula without synbiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Does Heme Oxygenase-1 Induction Ameliorate Cardiac Injury After Myocardial Infarction?
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Heme arginate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blood Flow Changes in Femoral-popliteal Bypass Grafts After Neuromuscular Electrical Stimulation (NMES).
Status: WITHDRAWN
Conditions: Peripheral Arterial Disease|Peripheral Artery Disease|Peripheral Vascular Disease|Femoral Popliteal Occlusion
Interventions: DEVICE: REVITIVE® device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Honey and Nigella Sativa in COVID-19 Prophylaxis
Status: UNKNOWN
Conditions: Covid19
Interventions: DRUG: Honey|DRUG: Nigella sativa seed|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Coagulation Factors Alterations in Patients Undergoing Complex Thoraco-abdominal Aortic Aneurysm Repair
Status: NOT_YET_RECRUITING
Conditions: Thoraco-abdominal Aortic Aneurysm Repair|Coagulation Factors Alterations|Platelet Activation
Interventions: OTHER: Patients undergoing complex thoraco-abdominal aortic aneurysm repair
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Brentuximab Vedotin and Bendamustine for the Treatment of Relapsed or Refractory Follicular Lymphoma
Status: RECRUITING
Conditions: Recurrent Follicular Lymphoma|Refractory Follicular Lymphoma
Interventions: DRUG: Bendamustine Hydrochloride|DRUG: Brentuximab Vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of Three Dose Levels of OVX836 Candidate Vaccine Against Influenza in Healthy Volunteers.
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: OVX836-003|BIOLOGICAL: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Talc Pleurodesis in Patients With Recurrent Malignant Pleural Effusion
Status: COMPLETED
Conditions: Recurrent Malignant Pleural Effusion.
Interventions: PROCEDURE: Videothoracoscopic talc poudrage (VT).|PROCEDURE: Talc slurry through a chest tube (DT).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mealtime Walking Study to Improve Postprandial Metabolic Response
Status: COMPLETED
Conditions: PreDiabetes|Postprandial Hyperglycemia
Interventions: OTHER: 15-minute walk at preferred walking speed.|DIETARY_SUPPLEMENT: Fiber|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Paired Marrow Aspirations to Assess Assays in Sensitized Renal Allograft Recipients
Status: RECRUITING
Conditions: Transplantation, Kidney|Living Donors|Kidney Transplant Recipients
Interventions: PROCEDURE: bone marrow aspirations|PROCEDURE: lymph node collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of the Efficacy and Safety of Asenapine in Participants With an Acute Exacerbation of Schizophrenia (P05688)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Asenapine|DRUG: Placebo Asenapine|DRUG: Olanzapine|DRUG: Placebo Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacological Treatment of a Rare Genetic Disease: N-acetylcysteine in Myopathy Associated Selenoprotein N-related Myopathy (SEPN1-RM)
Status: TERMINATED
Conditions: Selenoprotein N-related Myopathy
Interventions: DRUG: N-Acetylcysteine followed by Placebo|DRUG: Placebo followed by N-Acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RELIEF Europe Study
Status: TERMINATED
Conditions: GERD|Gastroesophageal Reflux Disease|Obesity|LSG|Laparoscopic Sleeve Gastrectomy
Interventions: DEVICE: The LINX® Reflux Management System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Cascade Feasibility Pilot (HF) Phase 3
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: Non-invasive continuous remote monitoring with structured escalation pathway|OTHER: Affective Analysis of Participant Response to Continuous Remote Patient Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Correlation of Different Signs for Assessment of Dry Eye Syndrome
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: OTHER: Ocular scattering of the tear film|OTHER: Optical Coherence Tomography (OCT)|OTHER: Measurement of tear film osmolarity
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Radiation Therapy Followed by Tislelizumab and Anlotinib Aeoadjuvant/Adjuvant Therapy for Stage II-IIIA NSCLC
Status: NOT_YET_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Anlotinib Hydrochloride Capsule|DRUG: Tislelizumab Injection|RADIATION: Hypofractionated Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nalbuphine Versus Morphine for Mucositis Pain in Pediatric Cancer Patients
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Stem Cell Leukemia
Interventions: DRUG: Nalbuphine|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating Safety and Efficacy of TOL101 Induction Versus Anti-Thymocyte Globulin to Prevent Kidney Transplant Rejection
Status: UNKNOWN
Conditions: End Stage Renal Disease|Renal Transplant
Interventions: DRUG: Anti-Thymocyte Globulin|DRUG: TOL101|DRUG: TOL101|DRUG: Steroids|DRUG: Tacrolimus|DRUG: Mycophenolate mofetil (MMF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of 2% Lignocaine Solution in Pain During Removal of Nasal Pack
Status: WITHDRAWN
Conditions: Nasal Pack Removal
Interventions: DRUG: Lignocaine 2% Injection 20Ml Vial (Product)|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Developing and Testing Mobile Health Question Prompt List in Gastroesophageal Reflux Disease
Status: NOT_YET_RECRUITING
Conditions: Gastroesophageal Reflux|Patient Activation
Interventions: BEHAVIORAL: Use of mHealth Question Prompt List app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Clinical Trial on Effectiveness and Safety of Hydrogen Generator to Treat Dyspnea for the Patients With Tracheal Stenosis: A Randomized, Double-blind and Single-center Clinical Study
Status: UNKNOWN
Conditions: Tracheal Stenosis
Interventions: DEVICE: Hydrogen generator treatment|DEVICE: Oxygen-making machine treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Probiotics in Pre-diabetic Adolescents
Status: COMPLETED
Conditions: Obesity, Childhood
Interventions: DIETARY_SUPPLEMENT: Vivomixx|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Circulating miRNAs and Bone Microstructure in Adults With Hypophosphatasia
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypophosphatasia|Bone Diseases, Metabolic|Bone
Interventions: OTHER: HR-pQCT scans, BMD measurements, bone specific circulating microRNAs (miRNAs)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 Trial)
Status: UNKNOWN
Conditions: Cardiac Surgery|Post-pericardiotomy Syndrome|Atrial Fibrillation|Pericardial Effusion|Pleural Effusion
Interventions: DRUG: Colchicine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Extended Cold Stored Apheresis Platelets in Cardiac Surgery Patients
Status: RECRUITING
Conditions: Hemorrhage|Platelets; Defect|Bleeding|Surgical Blood Loss
Interventions: BIOLOGICAL: Cold stored platelets in 100% plasma stored for 10-14 days|BIOLOGICAL: Room temperature stored platelets in 100% plasma stored for up to 7 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Obinutuzumab + Bendamustine (BG) in Participants With Previously Untreated Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Bendamustine|DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Compare Pharmacokinetics After Administration of ATB-101 or Co-administration of ATB-1011 and ATB-1012
Status: COMPLETED
Conditions: Healthy Adult Volunteers
Interventions: DRUG: ATB-101, ATB-1011, ATB-1012
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Bolus of Phenylephrine vs. Norepinephrine in Preventing Hypotension After Spinal Anesthesia
Status: COMPLETED
Conditions: Anesthesia, Spinal and Epidural|Adverse Effect|Hypotension|Complications, Cesarean Section
Interventions: DRUG: Phenylephrine|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: PSMAtrack-tracking Changes in PSMA-PET During Initial Therapy for Metastatic Hormone-sensitive Prostate Cancer
Status: NOT_YET_RECRUITING
Conditions: Metastatic Prostate Cancer|Hormone Sensitive Prostate Cancer|Metastatic Hormone-sensitive Prostate Cancer (mHSPC)
Interventions: DRUG: 18F-rhPSMA-7.3|DEVICE: PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Nebivolol and Metoprolol With Exercise and Angiotensin II in Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Metoprolol succinate|DRUG: Nebivolol|PROCEDURE: Forearm blood flow|PROCEDURE: Microneurography|PROCEDURE: Rhythmic handgrip exercise|PROCEDURE: Lower body negative pressure|DRUG: Angiotensin II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 1 SAD/MAD Study of RLS-0071 in Healthy Volunteers in Support of a COVID-19 Development Program
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: RLS-0071|DRUG: Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Candonilimab (AK104) Plus Preoperative Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma (ESCC)
Status: NOT_YET_RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: AK104, nab-paclitaxel, carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Response During Examination for Retinopathy of Prematurity
Status: COMPLETED
Conditions: Retinopathy of Prematurity
Interventions: BEHAVIORAL: suck 12.5% dextrose in water 5 minutes before the procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Efficacy of a Single PBF-680 Oral Administration to Attenuate Adenosine 5'-Monophosphate Challenge-induced Airway Hyperresponsiveness in Mild-to-moderate Asthmatics
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: PBF-680 5 mg|DRUG: PBF-680 20 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in People With Pulmonary Fibrosis to Monitor Cough With a Wearable Device
Status: COMPLETED
Conditions: Pulmonary Fibrosis
Interventions: DEVICE: A wearable cough monitoring device, the Strados Labs RESPᵀᴹ sensor, with an accompanying mobile application (App) for data collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment
Status: RECRUITING
Conditions: Opioid Use Disorder|Chronic Pain
Interventions: DRUG: Patient-Oriented Dosing (POD)|BEHAVIORAL: Pain Self-Management (PSM)|BEHAVIORAL: Usual Care|DRUG: Standard Buprenorphine Dosing Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Famciclovir 1-day Treatment Compared to 3-day Treatment With Valacyclovir in Adults With Recurrent Genital Herpes
Status: COMPLETED
Conditions: Genital Herpes
Interventions: DRUG: Famciclovir|DRUG: Valacyclovir|DRUG: Placebo matching famciclovir|DRUG: Placebo matching valacyclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intraorifice Barrier on Healing of Apical Periodontitis
Status: COMPLETED
Conditions: Apical Periodontitis
Interventions: PROCEDURE: Intraorifice barrier of GIC|PROCEDURE: Base of GIC|PROCEDURE: Direct composite restoration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Irritation Potential of Tazarotene Foam on Skin in Healthy Volunteers
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Tazarotene Foam|DRUG: Vehicle Foam|DRUG: Sodium Laural Sulfate|DRUG: Distilled Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of FES and Therapeutic Exercise on SCI Patients Skeletal Muscles, Sitting Balance, Posture and Quality of Life
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: OTHER: FES+TE|OTHER: TE|OTHER: REF-FES+TE|OTHER: REF-TE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mitochondrial Dysfunction of Alveolar and Circulating Immune Cells During Acute Respiratory Distress Syndrome: Impact of Infectious Aggression and Alveolar Stretching as a Result of Mechanical Ventilation.
Status: TERMINATED
Conditions: Lung Diseases|Mechanical Ventilation|Bronchoalveolar Lavage
Interventions: BIOLOGICAL: bronchoalveolar lavage fluid (BAL)|BIOLOGICAL: Venous blood
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neratinib and Everolimus, Palbociclib, or Trametinib in Treating Participants With Refractory and Advanced or Metastatic Solid Tumors With EGFR Mutation/Amplification, HER2 Mutation/Amplification, or HER3/4 Mutation or KRAS Mutation
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|EGFR Gene Amplification|EGFR Gene Mutation|ERBB2 Gene Amplification|ERBB2 Gene Mutation|ERBB3 Gene Mutation|ERBB4 Gene Mutation|KRAS Gene Mutation|Metastatic Malignant Solid Neoplasm|Refractory Malignant Solid Neoplasm
Interventions: DRUG: Everolimus|DRUG: Neratinib|DRUG: Palbociclib|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulse Contour Analysis and Tissue Oxymetry in Changing Vascular Tone
Status: COMPLETED
Conditions: Cardiac Output, High|Cardiac Output, Low|Vasodilation|Vasoconstriction|Hemodynamics
Interventions: DEVICE: Vigileo TM / Flotrac TM (Minimally invasive cardiac output system consisting of arterial line sensor and cardiac output monitor)|OTHER: Passive leg raising|OTHER: Volume challenge / Change of vasoactive drugs or inotropics|DEVICE: Inspectra TM/O-To-See TM (Tissue oxymetry with near infrared spectroscopy and laser-Doppler)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trapeziectomy vs. Trapeziometacarpal Limited Excision for Thumb Base Osteoarthritis
Status: RECRUITING
Conditions: Thumb Osteoarthritis
Interventions: PROCEDURE: trapeziometacarpal limited excision|PROCEDURE: Trapeziectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Noninvasive Ventilation on Physical Activity and Inflammation in COPD Patients
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease|Hypercapnic
Interventions: DRUG: Control|DEVICE: NIMV group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Modern Technologies in Neurorehabilitation
Status: NOT_YET_RECRUITING
Conditions: Neurorehabilitation|Nervous System Diseases|Biomedical Enhancement|Physical Activity
Interventions: OTHER: Rehabilitation program with the use of mechanical vibration using the Vibramoov device and conventional physiotherapy|OTHER: Rehabilitation program with gait training using the Ekso GT exoskeleton and conventional physiotherapy|OTHER: Rehabilitation program with the use of gait training with the use of a RoboGait stationary robot and conventional physiotherapy.|OTHER: Rehabilitation program with the use of gait training with the use of the ZEBRIS treadmill and conventional physiotherapy|OTHER: Rehabilitation program with the use of upper limb function training with the use of the PABLO device and conventional physiotherapy|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on the Effect of Changing From Preserved Prostaglandin Formulations to Preservative Free Tafluprost on Tear Film Thickness
Status: COMPLETED
Conditions: Glaucoma, Open-Angle|Ocular Hypertension
Interventions: DRUG: Tafluprost 15µg/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-Guided Erector Spinae Plane Block or Interscalen Brachial Plexus Block Following Arthroscopic Shoulder Surgery
Status: COMPLETED
Conditions: Shoulder Syndrome
Interventions: OTHER: Erector spinae plane block (Group E)|OTHER: Interscalen brachial plexus block (Group I)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DPP4 Inhibition & Beta Cell Function
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Active Comparator: Sitagliptin|DRUG: Placebo Comparator - No Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Animated Education on Anxiety and Vascular Complications
Status: RECRUITING
Conditions: Cardiac Catheterization
Interventions: BEHAVIORAL: Animated Education Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Prophylactic Probiotic Lactobacilli in Enteral Feeding on Nosocomial Pneumonia Rates in Critically Ill Patients
Status: COMPLETED
Conditions: Critical Illness
Interventions: DRUG: Probiotic Lactobacillus|OTHER: Lactose Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: To Compare and Evaluate the Efficacy and Safety of Ganilever PFS(Prefilled Syringe) and Orgalutran®
Status: COMPLETED
Conditions: Controlled Ovarian Stimulation
Interventions: DRUG: Ganirelix acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced Exposure Study Using the CHTP 1.2 With 5 Days in a Confinement Setting Followed by 85 Days in an Ambulatory Setting.
Status: COMPLETED
Conditions: Smoking
Interventions: OTHER: CHTP 1.2|OTHER: CC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of Nutrition Supplement for Treatment of Men With Hair Loss
Status: COMPLETED
Conditions: Androgenetic Alopecia
Interventions: DIETARY_SUPPLEMENT: HCap Formula|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Web-Based Cardiovascular Disease Risk Factor Reduction Program Among American Indians
Status: COMPLETED
Conditions: Cardiovascular Diseases|Diabetes Mellitus, Type 2|Hypertension|Obesity|Tobacco Use Cessation
Interventions: BEHAVIORAL: Chronic disease management Web-based software
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Role of Trimetazidine on Right Ventricle Function in Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Precapillary Pulmonary Hypertension
Interventions: DRUG: Trimetazidine|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Buprenorphine on Responses to Verbal Tasks
Status: COMPLETED
Conditions: Basic Science
Interventions: DRUG: Buprenorphine 0.2 MG Sublingual Tablet|DRUG: Placebo|DRUG: Buprenorphine 0.4 MG Sublingual Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fracture (FX) Improvement With Teriparatide: FiX-IT Study
Status: COMPLETED
Conditions: Osteoporosis|Atypical Femoral Fracture
Interventions: DRUG: teriparatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SOLTIVE™ Laser Enucleation for Treatment of Benign Prostatic Hyperplasia
Status: UNKNOWN
Conditions: BPH|Benign Prostatic Hyperplasia
Interventions: OTHER: SOLTIVE Thulium Laser|OTHER: Standard of Care (Holmium Laser)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Microbiological Structure of Pathogens of Periprosthetic Infection of Large Joints in the Post-Covid Period
Status: COMPLETED
Conditions: Joint Infection|Periprosthetic Left Knee Joint Infection
Interventions: DIAGNOSTIC_TEST: Microbiological examination of the patient's biological material and determination of antibiotic resistance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: EBUS-Guided TBNA Increases the Diagnostic Yield of Peripheral Pulmonary Lesions
Status: COMPLETED
Conditions: Peripheral Pulmonary Lesions
Interventions: DEVICE: Olympus NA-2C-1 Transbronchial needle aspiration (TBNA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Role of 5-alpha Reductase in Mediating Testosterone Actions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Testosterone Enanthate|DRUG: Dutasteride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of TXA Oral Sol 5% in Patients Treated With DOACs or VKA and Undergoing a Single or Multiple Tooth Extraction
Status: RECRUITING
Conditions: Bleeding From Teeth|Bleeding Prophylaxis
Interventions: DRUG: Tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Different Methods for Reducing Pain From Influenza Vaccine Injections
Status: COMPLETED
Conditions: Pain|Anxiety
Interventions: DRUG: Liposomal lidocaine|DRUG: Vapocoolant spray|OTHER: Rubbing adjacent to the injection site|OTHER: Distraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Visits Versus Telephone Calls for Postoperative Care
Status: COMPLETED
Conditions: Satisfaction|Postoperative Complications|Pelvic Floor Disorder
Interventions: BEHAVIORAL: Telephone follow-up|BEHAVIORAL: Outpatient Clinic Visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Eye Surface Properties After Using Dexamethasone Drops With and Without Preservatives in Patients After Cataract Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Cataract|Surgical Injury|Healing Wound
Interventions: OTHER: preservative-free solution of standard post-cataract eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A 56-Week Extension to a Clinical Study to Assess the Efficacy and Safety of Vildagliptin Compared to Placebo in Drug Naive Patients With Type 2 Diabetes and Mild Hyperglycemia
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: SMS: Substrate Modification Study in Patients Getting an Implantable Cardioverter Defibrillator (ICD)
Status: COMPLETED
Conditions: Tachycardia, Ventricular
Interventions: PROCEDURE: ICD Ablation plus VT-ablation|DEVICE: ICD Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Symmetric on Total Knee Arthroplasty (TKA)
Status: COMPLETED
Conditions: Wound Closure
Interventions: DEVICE: "STRATAFIX™ Symmetric" Knotless Tissue|DEVICE: VICRYL® PLUS|DEVICE: "STRATAFIX Spiral" sutures|DEVICE: DERMABOND™ Advance™ Skin Closure System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Dose Ranging Study Comparing Different Combinations of Adjuvanted and Non-adjuvanted Influenza Vaccines in Healthy Children 6 to <36 Months of Age
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Adjuvanted and un-adjuvanted influenza vaccines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Glutathione vs KI in Reducing SDF Staining When Used in Treatment of Primary Carious Teeth
Status: UNKNOWN
Conditions: Discoloration, Tooth
Interventions: DRUG: Potassium Iodide or Glutathione
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Social Experiences and Demographic Factors in the Regulation of Immune Cells
Status: NOT_YET_RECRUITING
Conditions: Perceived Discrimination|RNA|Inflammatory Response
Interventions: BEHAVIORAL: Cyberball
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ertapenem Sodium vs. Piperacillin/Tazobactam in the Treatment of Complicated Intra-Abdominal Infections (0826-037)
Status: COMPLETED
Conditions: Complicated Intra-Abdominal Infections
Interventions: DRUG: MK0826, /Duration of Treatment : 8 Weeks|DRUG: Comparator : piperacillin sodium (+) tazobactam sodium /Duration of Treatment : 8 Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison Study of Rituximab Plus Sargramostim to Rituximab Alone for Relapsed Follicular B-cell Lymphoma, a Form of Non-Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Lymphoma, Follicular
Interventions: DRUG: Sargramostim (Leukine)|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of Intranasal PIV5 COVID-19 Vaccine Expressing SARS-CoV-2 Spike Protein in Healthy Adults and Adolescents
Status: COMPLETED
Conditions: Covid19
Interventions: BIOLOGICAL: CVXGA1 low dose|BIOLOGICAL: CVXGA1 high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Splenectomy and Azygoportal Disconnection With Intraoperative Endoscopic Variceal Ligation
Status: COMPLETED
Conditions: Cirrhosis|Hypertension|Splenectomy|Laparoscopy
Interventions: PROCEDURE: laparoscopic splenectomy and azygoportal disconnection with intraoperative endoscopic variceal ligation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigate the Impact of Early Treatment Initiation With Tiotropium in Patients Recovering From Hospitalization for an Acute COPD Exacerbation 1
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: tiotropium bromide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Detecting Malingering Detection Using Eye Movements and Response Time (MDER)
Status: UNKNOWN
Conditions: Traumatic Brain Damage|Chronic Pain
Interventions: BEHAVIORAL: Sub-optimal effort|BEHAVIORAL: optimal effort
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: B-Cell Activating Factor Receptor (BAFFR)-Based Chimeric Antigen Receptor T-Cells With Fludarabine and Cyclophosphamide Lymphodepletion for the Treatment of Relapsed or Refractory B-cell Hematologic Malignancies
Status: RECRUITING
Conditions: B-Cell Non-Hodgkin Lymphoma|Recurrent Chronic Lymphocytic Leukemia|Recurrent Diffuse Large B-Cell Lymphoma|Recurrent Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Recurrent Transformed Chronic Lymphocytic Leukemia|Refractory Chronic Lymphocytic Leukemia|Refractory Diffuse Large B-Cell Lymphoma|Refractory Follicular Lymphoma|Refractory Mantle Cell Lymphoma|Refractory Marginal Zone Lymphoma|Refractory Small Lymphocytic Lymphoma|Refractory Transformed Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: Autologous BAFFR-targeting CAR T Cells|DRUG: Bendamustine|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration and Biopsy|PROCEDURE: Computed Tomography|DRUG: Cyclophosphamide|PROCEDURE: Echocardiography|DRUG: Fludarabine|PROCEDURE: Leukapheresis|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Efficacy of ALT-711 (Alagebrium) in Chronic Heart Failure
Status: TERMINATED
Conditions: Chronic Heart Failure
Interventions: DRUG: ALT-711|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sacral Neuromodulation (SNM) With InterStimTM for Bowel Dysfunction Following Surgery for Rectal Cancers With Sphincter Preservation
Status: TERMINATED
Conditions: Rectal Cancer|for Bowel Dysfunction Following Surgery for Rectal Cancers
Interventions: DEVICE: Implantation of the InterStimTM|BEHAVIORAL: MSK BFI questionnaires|BEHAVIORAL: The Low Anterior Resection Score (LARS) questionnaires|BEHAVIORAL: The EuroQOL5D questionnaires|BEHAVIORAL: The Fecal incontinence Quality of Life Scale (FIQOL) questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Immediate Post-Operative Intravesical Instillation of Chemophase® in Patients With Superficial Bladder Cancer
Status: COMPLETED
Conditions: Superficial Bladder Cancer
Interventions: DRUG: Chemophase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate if Benzalkonium Chloride (BAK) in a Quinolone Eyedrop Reduces the Likelihood of Developing Resistant Organisms
Status: COMPLETED
Conditions: Anti-biotic Resistance
Interventions: DRUG: moxifloxacin 0.5% HCI ophthalmic solution|DRUG: gatifloxacin ophthalmic solution 0.3%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Oral Sildenafil on Mortality in Adults With PAH
Status: TERMINATED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: sildenafil citrate|DRUG: sildenafil citrate|DRUG: sildenafil citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of C-MAC Video-stylet Versus Fiberoptic Bronchoscope for Awake Intubation
Status: UNKNOWN
Conditions: Difficult Mask Ventilation|Difficult Intubation
Interventions: DEVICE: C-MAC VS|DEVICE: flexible fibreoptic bronchoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Nebivolol on Oxidative Stress and Endothelial Progenitor Cells
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Nebivolol|DRUG: Metoprolol succinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy and Long Term Effects of Transcranial Direct Current Stimulation (tDCS) in Children With Attention Deficit/Hyperactivity Disorder (ADHD)
Status: RECRUITING
Conditions: Attention Deficit Hyperactivity Disorder|Transcranial Direct Current Stimulation
Interventions: OTHER: Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Mitoxantrone HCL Liposome Injection in Patients With Relapsed DLBCL and PT/NKCLs
Status: UNKNOWN
Conditions: Relapsed DLBCL and PT/NKCLs
Interventions: DRUG: Mitoxantrone HCL Liposome Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Adrenalectomy Versus Radiofrequency Ablation
Status: UNKNOWN
Conditions: Hyperaldosteronism|Conn Syndrome|Adrenocortical Adenoma
Interventions: PROCEDURE: Radiofrequency Ablation|PROCEDURE: Laparoscopic Adrenalectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of the Safety, Tolerability, PK & PD of Lomitapide in Japanese and Caucasian Subjects With Elevated LDL-C
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: lomitapide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ileal Bile Acid Transporter Inhibitor in Functional Constipation
Status: COMPLETED
Conditions: Functional Constipation
Interventions: DRUG: A3309|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sitagliptin/Metformin Fixed-Dose Combination (FDC) Compared to Glimepiride in Participants With Type 2 Diabetes Mellitus (MK-0431A-202)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin/Metformin FDC|DRUG: Comparator: Glimepiride|DRUG: Matching placebo to Sitagliptin/Metformin FDC|DRUG: Matching placebo to glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label Study of APX001 for Treatment of Patients With Candidemia/Invasive Candidiasis Caused by Candida Auris
Status: COMPLETED
Conditions: Candidemia|Invasive Candidiases|Candida Infection
Interventions: DRUG: APX001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A ED-based Intervention to Improve Antihypertensive Adherence
Status: COMPLETED
Conditions: Hypertensive Emergency|Hypertension|Blood Pressure
Interventions: BEHAVIORAL: ED-based behavioral intervention|BEHAVIORAL: ED usual care plus education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy, Safety and Tolerability of Levodopa-Carbidopa Intestinal Gel in Levodopa-Responsive Parkinson's Subjects
Status: COMPLETED
Conditions: Advanced Parkinson's Disease
Interventions: DRUG: Levodopa carbidopa intestinal gel (LCIG)|DRUG: Placebo Gel|DRUG: Levodopa-carbidopa (LC) oral encapsulated immediate release (IR) tablets|DRUG: Placebo (PBO) oral capsules|DEVICE: CADD-Legacy® 1400 ambulatory infusion pump|DEVICE: PEG tube|DEVICE: J-tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Central Sleep Apnea : Physiologic Mechanisms to Inform Treatment
Status: RECRUITING
Conditions: Sleep Disordered Breathing|Able Bodied
Interventions: DRUG: Acetazolamide + supplemental oxygen + PAP therapy|DRUG: Zolpidem + PAP therapy|DRUG: Buspirone + PAP therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Model-based Electrical Brain Stimulation
Status: RECRUITING
Conditions: Medication Refractory Epilepsy Patients With Electrodes Already Implanted Based on Clinical Criteria for Standard Monitoring
Interventions: OTHER: model-based electrical brain stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Safety and Tolerability of CKD-510 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: CKD-510 single dose|DRUG: CKD-510 food effect|DRUG: CKD-510 multiple dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Penile Vibratory Stimulation in the Prevention of Sexual Dysfunction and Urinary Incontinence After Radical Prostatectomy
Status: RECRUITING
Conditions: Erectile Dysfunction Following Radical Prostatectomy|Incontinence
Interventions: DEVICE: Penile vibrator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gluing Lacerations Utilizing Epinephrine
Status: COMPLETED
Conditions: Lacerations
Interventions: DRUG: LET - Lidocaine Epinephrine Tetracaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Arimoclomol in Patients Diagnosed With Gaucher Disease Type 1 or 3
Status: TERMINATED
Conditions: Gaucher Disease, Type 1|Gaucher Disease, Type 3
Interventions: DRUG: Arimoclomol|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse
Status: COMPLETED
Conditions: Suicidal Ideation|Depression|Alcohol Abuse
Interventions: DRUG: Intranasal ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fatty Acid Amide Hydrolase (FAAH) Inhibitor Treatment of Cannabis Use Disorder (CUD)
Status: COMPLETED
Conditions: Cannabis Use Disorder
Interventions: DRUG: PF 04457845|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Traumatic Nightmares Treated by NightWare (To Arouse Not Awaken)
Status: ENROLLING_BY_INVITATION
Conditions: Stress Disorders, Post-Traumatic|Combat Disorders|Ptsd|Nightmare|Nightmares, REM-Sleep Type|Nightmare Disorder With Associated Non-Sleep Disorder
Interventions: DEVICE: NightWare Therapeutic System|DEVICE: Sham NightWare
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Telitacicept in Patients With Primary IgA Nephropathy
Status: RECRUITING
Conditions: IgA Nephropathy
Interventions: BIOLOGICAL: Telitacicept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Re-exposure of EHMI-8 Human Volunteers to Live Malaria Sporozoites
Status: COMPLETED
Conditions: P. Falciparum Malaria
Interventions: BIOLOGICAL: Exposure to 5 P. falciparum infected mosquitoes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Expression of Ku70/XRCC6 in Waldenström's Macroglobulinemia
Status: COMPLETED
Conditions: Waldenström Macroglobulinemia
Interventions: BIOLOGICAL: Blood or bone marrow samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Stem Cell Transplantation for Children Affected With Osteopetrosis
Status: TERMINATED
Conditions: Osteopetrosis
Interventions: PROCEDURE: Stem Cell Transplantation|DEVICE: Miltenyi Biotec CliniMACS|DRUG: Systemic chemotherapy and antibodies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preemptive CIML NK Cell Therapy After Hematopoietic Stem Cell Transplantation
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Leukemia|Leukemia, Myeloid|Myelodysplastic Syndromes|Myeloproliferative Neoplasm|Myeloproliferative Disorders
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT