pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Combining Sodium Valproate With Standard-of-care EGFR (Epidermal Growth Factor Receptor) Monoclonal Antibody Treatment in Patients With Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Sodium Valproate|DRUG: Panitumumab|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect Of Extracorporeal Shockwave Therapy on Tension-Type Headache in Adolescent Females
Status: COMPLETED
Conditions: Tension-Type Headache
Interventions: DEVICE: Extracorporeal Shockwave Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biodistribution of [11C]Acetoacetate/[18F]Fluorodeoxyglucose in Subjects With Risk Factors for Alzheimer's Disease
Status: ENROLLING_BY_INVITATION
Conditions: Mild Cognitive Impairment
Interventions: OTHER: [11C]Acetoacetate[18F]Fluorodeoxyglucose positron emission tomography scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Concurrent Carboplatin and Reduced Dose Craniospinal Radiation for Medulloblastoma and Primitive Neuroectodermal Tumor (PNET)
Status: COMPLETED
Conditions: Metastatic Medulloblastoma|High Risk Supratentorial PNET|Metastatic PNET
Interventions: DRUG: Carboplatin|DRUG: Vincristine|RADIATION: 24 Gy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Overnight Use of Electroacustimulation on Postoperative Nausea and Vomiting in the Outpatient Surgery Population
Status: WITHDRAWN
Conditions: Post-operative Nausea and Vomiting
Interventions: DEVICE: Battery-operated electroacustimulation device (Inactive)|DEVICE: Battery-operated electroacustimulation device (Active)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Prevalence of Anatomical Variants of Dural Sinuses by Magnetic Resonance Venography Evaluation in Sohag
Status: RECRUITING
Conditions: Anatomical Variants of Dural Sinuses by Magnetic Resonance Venography
Interventions: OTHER: Magnetic Resonance Venography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Indoximod or Placebo Plus Pembrolizumab or Nivolumab for Subjects With Unresectable or Metastatic Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: Pembrolizumab|DRUG: Nivolumab|DRUG: Indoximod
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of MDI-1228_mesylate Ophthalmic Solution in Healthy Adults
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: MDI-1228_mesylate Ophthalmic Solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Infants Fed Extensively Hydrolyzed Casein-Based Infant Formulas
Status: COMPLETED
Conditions: Infant Development
Interventions: OTHER: Experimental Infant Formula|OTHER: Control Infant Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Relationship Between Biological Profiles and Clinical Evolutions Within the Same Cluster COVID-19 (COVIDCOLLECT)
Status: UNKNOWN
Conditions: Covid19|Contact Case
Interventions: BIOLOGICAL: Biological collection with nasopharyngeal samples, saliva, blood, stool and urine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ivabradine Versus Beta-blockers in the Treatment of Inappropriate Sinus Tachycardia
Status: COMPLETED
Conditions: Inappropriate Sinus Tachycardia
Interventions: DRUG: Ivabradine|DRUG: Beta blocker
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Integration Success of Osseotite Dental Implants Placed Using Different Insertion Procedures
Status: COMPLETED
Conditions: Partial Edentulism|Tooth Disease
Interventions: PROCEDURE: High torque insertion|PROCEDURE: Low torque insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of 212Pb-VMT-alpha-NET in Patients With Neuroendocrine Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Neuroendocrine Tumors|Neuroendocrine Tumor of the Lung|Neuroendocrine Tumor Grade 1|Neuroendocrine Tumor Grade 2|Neuroendocrine Tumor of Pancreas
Interventions: DRUG: [212Pb] VMT-α-NET|DIAGNOSTIC_TEST: [203Pb] VMT-α-NET SPECT/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Natural Components Mixture in the Treatment of Non Alcoholic Fatty Liver Disease (NAFLD)
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease
Interventions: DIETARY_SUPPLEMENT: nutraceutical mixture|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BBP-398 in Combination With Osimertinib in Locally Advanced or Metastatic NSCLC Patients With EGFR Mutations
Status: TERMINATED
Conditions: NSCLC
Interventions: DRUG: BBP-398|DRUG: osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Biological Nurturing Education to Pregnant Women on Breastfeeding Status
Status: ENROLLING_BY_INVITATION
Conditions: Breastfeeding
Interventions: BEHAVIORAL: Breastfeeding Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Biodentine Vital Pulpotomy in Immature Molars
Status: COMPLETED
Conditions: Pulp Exposure, Dental
Interventions: PROCEDURE: pulpotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dietary Nitrates on Physical Performance and Vascular Function in Chronic Kidney Disease
Status: COMPLETED
Conditions: Kidney Disease, Chronic|Endothelial Dysfunction
Interventions: DIETARY_SUPPLEMENT: Beet It Sport Shot|DIETARY_SUPPLEMENT: Nitrate-depleted placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Evaluation of Ropinirole Prolonged Release/Extended Release (PR/XR) Tablet for Adjunctive Therapy to L-dopa in Subjects With Advanced Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: ropinirole PR/XR|DRUG: ropinirole IR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study on the Effectiveness, Comfort and Compliance of HFNC and Noninvasive Mechanical Ventilation BiPAP Mode in the Treatment of Hypoxemia Patients
Status: NOT_YET_RECRUITING
Conditions: Hypoxemia
Interventions: DEVICE: Non-invasive BiPAP ventilation|DEVICE: HFNC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Novamin on Streptococcus Mutans Count in Dental Plaque of High Caries Risk Children
Status: COMPLETED
Conditions: Dental Plaque|Dental Caries
Interventions: OTHER: Novamin containing toothpaste|OTHER: Fluoride containing toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Revitalization of Immature Permanent Teeth With Necrotic Pulps Using SHED Cells
Status: UNKNOWN
Conditions: Dental Pulp Necrosis|Permanent Incisor Avulsed by Trauma
Interventions: DEVICE: scaffold-free SHED-derived pellet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electroencephalogram Recording in Patients With Systemic Lupus Erythematosus
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: OTHER: Electroencephalography (EEG) signals, which will be detected noninvasively from dry scalp surface electrodes while the subjects are in a state of wakeful rest.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PF-06863135 As Single Agent And In Combination With Immunomodulatory Agents In Relapse/Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: PF-06863135 monotherapy IV or SC|DRUG: PF-06863135 + dexamethasone|DRUG: PF-06863135 + lenalidomide|DRUG: PF-06863135 + pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tisotumab Vedotin Continued Treatment in Patients With Solid Tumors.
Status: COMPLETED
Conditions: Ovary Cancer|Cervix Cancer|Endometrium Cancer|Bladder Cancer|Prostate Cancer|Esophagus Cancer|Lung Cancer, Nonsmall Cell|Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Tisotumab Vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative A1 vs A2 Formula and Breast Feeding on Alimentation and Gastrointestinal Digestion for the Infant
Status: COMPLETED
Conditions: Intestinal Absorption
Interventions: DIETARY_SUPPLEMENT: Oral consumption of Nutricia Aptamil Stage 1 formula|DIETARY_SUPPLEMENT: Oral consumption of a2® Platinum Stage 1 formula|DIETARY_SUPPLEMENT: Oral consumption of breast milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Home Detox in Medication Overuse Headache (MOH) During Covid-19 Emergency
Status: UNKNOWN
Conditions: Migraine, Hemicrania
Interventions: DRUG: Symptomatic drugs|DRUG: Bridge therapy|BEHAVIORAL: Mindfulness program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing an Evidence-Based, Disseminable, Free Internet-Based Parenting Program
Status: COMPLETED
Conditions: Parenting Practices
Interventions: BEHAVIORAL: Motivational Enhancement|BEHAVIORAL: Simplification|BEHAVIORAL: Gamification|BEHAVIORAL: Low Engagement Nudges|BEHAVIORAL: Essentials for Parenting Toddlers and Pre-schoolers (EFP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety and the Activity of S095029 as Part of Combination Therapy in Advanced Gastroesophageal Junction/Gastric Cancers.
Status: NOT_YET_RECRUITING
Conditions: MSI-H/dMMR Gastroesophageal-junction Cancer|MSI-H/dMMR Gastric Cancer
Interventions: DRUG: S095029|DRUG: pembrolizumab 200 mg (KEYTRUDA ®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: bevacizumab|DRUG: docetaxel|DRUG: doxorubicin|DRUG: cyclophosphamide|DRUG: pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of [18F]-ML-10, as a PET Imaging Radiotracer, in Early Detection of Response of Brain Metastases of Solid Tumors to Radiation Therapy.
Status: UNKNOWN
Conditions: Brain Metastases|Solid Tumors
Interventions: DRUG: 2-(5-fluoro-pentyl)-2-methyl-malonic-acid ([18F]-ML-10)|RADIATION: Stereotactic Radio-Surgery (SRS) therapy|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Influence of Hepatic Insufficiency on the Pharmacokinetics of Elbasvir (MK-8742) (MK-8742-009)
Status: COMPLETED
Conditions: Hepatic Insufficiency
Interventions: DRUG: Elbasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Baby Vaccine Study (Sched3)
Status: COMPLETED
Conditions: Infectious Diseases
Interventions: BIOLOGICAL: DTaP/IPV/Hib vaccine|BIOLOGICAL: 13 valent Pneumococcal Conjugate Vaccine|BIOLOGICAL: Rotavirus vaccine|BIOLOGICAL: 4-component Meningococcal B vaccine|BIOLOGICAL: Meningococcal C/Hib vaccine (MenC/Hib vaccine)|BIOLOGICAL: Measles/Mumps/Rubella Vaccine (MMR vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Physiologic Analysis of Endoscopic Sleeve Gastroplasty (ESG)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-alcoholic Steatohepatitis (NASH)|Endoscopic Sleeve Gastroplasty|Non-alcoholic Fatty Liver Disease (NAFLD)|Endoscopic Ultrasound|Liver Function|Obesity|Liver Fibroses
Interventions: DIAGNOSTIC_TEST: Insulin Resistance|BEHAVIORAL: Quality of Life Assessment|DIAGNOSTIC_TEST: Liver Function Test|DIAGNOSTIC_TEST: Radiologic features of NASH|DIAGNOSTIC_TEST: Serologic features of NASH
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Tolerability Study of the Monoclonal Antibody CT-011 in Patients With Chronic Hepatitis C Genotype I Infection
Status: TERMINATED
Conditions: Chronic Hepatitis C
Interventions: DRUG: CT-011
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telmisartan for Treatment of COVID-19 Patients
Status: COMPLETED
Conditions: COVID-19 Drug Treatment
Interventions: DRUG: Telmisartan arm will receive 80 mg Telmisartan twice daily plus standard care.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Followed By Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer or Severe Aplastic Anemia
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases
Interventions: BIOLOGICAL: anti-thymocyte globulin|BIOLOGICAL: filgrastim|DRUG: cyclophosphamide|DRUG: fludarabine phosphate|PROCEDURE: umbilical cord blood transplantation|DRUG: methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aroplatin and Capecitabine in Patients With Advanced Colorectal Cancer Resistant to Standard Therapies
Status: UNKNOWN
Conditions: Colorectal Neoplasms
Interventions: DRUG: Aroplatin (Liposomal NDDP) in combination with capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate 9MW2821 Versus Chemotherapy in Subjects With Previously Treated Locally Advanced or Metastatic Urothelial Cancer
Status: NOT_YET_RECRUITING
Conditions: Advanced Urothelial Carcinoma
Interventions: DRUG: 9MW2821|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modulation of Abeta Levels by GSK933776 in Alzheimer's Disease Patient
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: BIOLOGICAL: GSK933776|BIOLOGICAL: GSK933776|BIOLOGICAL: GSK933776
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Treatment of Cranial Molding Deformities in Preterm Infants
Status: COMPLETED
Conditions: Preterm Infants|Dolichocephaly|Positional Scaphocephaly
Interventions: DEVICE: Tortle Midliner
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Tolerability, Immunogenicity and Efficacy of HB-110 Administered by Electroporation in Chronic Hepatitis B Patients
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: GENETIC: HB-110
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role Of Angiogenic Factors In The Development Of Hepatorenal Syndrome
Status: TERMINATED
Conditions: Hepatorenal Syndrome|Renal Failure|Liver Diseases
Interventions: PROCEDURE: Blood Draws and a hepatectomy specimen|PROCEDURE: Blood draw - pre operative standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: EndoTAG-1 / Gemcitabine Combination Therapy to Treat Locally Advanced and/or Metastatic Adenocarcinoma of the Pancreas
Status: COMPLETED
Conditions: Adenocarcinoma|Metastasis|Pancreas Neoplasms
Interventions: DRUG: Gemcitabine alone|DRUG: EndoTAG-1 and Gemcitabine|DRUG: EndoTAG-1 and Gemcitabine|DRUG: EndoTAG-1 and Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Serum Vitamin D and Outcomes of Liver Transplantation in Cirrhotic Patients Undergoing Liver Transplantation and Effects of Vitamin D Supplementation in Post-transplant Period
Status: NOT_YET_RECRUITING
Conditions: Liver Transplant; Complications|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: vitamin D supplementation|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a New Nasal Pillows Mask for the Treatment of Obstructive Sleep Apnea
Status: WITHDRAWN
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: New nasal pillows mask with PAP therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Zoledronic Acid as Anti-Cancer Treatment in Metastatic Breast Cancer Patients
Status: COMPLETED
Conditions: First or Second Line HER2-negative Breast Cancer|Metastatic Disease Without Bone Metastasis
Interventions: DRUG: Zoledronic acid|DRUG: Standard Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on Savolitinib + Osimertinib in Treatment of EGFRm+/MET+ Locally Advanced or Metastatic NSCLC
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Savolitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Intraocular Pressure (IOP) Reduction Efficacy of Travoprost Ophthalmic Solution in Patients With Normal Tension Glaucoma
Status: COMPLETED
Conditions: Normal Tension Glaucoma|Ocular Hypertension
Interventions: DRUG: Travoprost Ophthalmic Solution 0.004%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Nerinetide in Participants With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy Excluding Thrombolysis
Status: COMPLETED
Conditions: Stroke, Acute
Interventions: DRUG: Placebo|DRUG: Nerinetide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Find Out the Optimal Dose of Caffeine in the Combination Tablet of Naproxen Sodium and Caffeine in Patients Experiencing Moderate to Severe Pain After Having Wisdom Teeth Removed
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Naproxen sodium/Caffeine (BAY2880376)|DRUG: Naproxen sodium (Aleve)|DRUG: Caffeine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optical Coherence Tomography Angiography Criteria Of The Choroidal Neovascular Membrane In Wet Age Related Macular Degeneration And In Pathological Myopia (Comparative Study).
Status: UNKNOWN
Conditions: Choroidal Neovascular Membrane In Wet Age Related Macular Degeneration And In Pathological Myopia
Interventions: DEVICE: Optical coherence tomography angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Active Cycle of Breathing Techniques With and Without Acapella in COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Active Cycle of breathing|OTHER: Active Cycle of breathing with Acapella
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3127804 With Ramucirumab in Participants With Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: LY3127804|DRUG: Ramucirumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Transcranial Direct Current Stimulation (tDCS) for Gait Function Improvement of Parkinson's Disease Patient
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DEVICE: Brain stimulation|DEVICE: Treadmill gait training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A STUDY TO COMPARE THE PHARMACOKINETICS OF PF-06835919 IN PARTICIPANTS WITH AND WITHOUT HEPATIC IMPAIRMENT
Status: COMPLETED
Conditions: Hepatic Impairment|Healthy Participants
Interventions: DRUG: PF-06835919 25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Depigoid Birch 5000 Longterm Study in Adults and Adolescents
Status: COMPLETED
Conditions: Allergic Rhinitis/Rhinoconjunctivitis +-Intermittent Asthma|Sensitization Against Betula Alba (Birch) Pollen
Interventions: BIOLOGICAL: s.c. injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nexavar for Neoadjuvant Treatment of Anaplastic Thyroid Cancer
Status: COMPLETED
Conditions: Thyroid Cancer, Anaplastic
Interventions: DRUG: Nexavar|PROCEDURE: operation|RADIATION: External radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparator Study Evaluating Patient Experience And Preference Of FFNS vs. FPNS
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial
Interventions: DRUG: FPNS|DRUG: FFNS|DRUG: placebo FFNS|DRUG: placebo FPNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Myofascial Pain Syndrome and Plantar Fasciitis Treatment
Status: COMPLETED
Conditions: Plantar Fascitis|Myofascial Pain Syndrome
Interventions: DEVICE: ESWT|PROCEDURE: Dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NAD+ and Exercise in FA
Status: RECRUITING
Conditions: Friedreich Ataxia 1
Interventions: DIETARY_SUPPLEMENT: Nicotinamide Riboside|DIETARY_SUPPLEMENT: Placebo|OTHER: Exercise Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The XENERA™ 1 Study Tests Xentuzumab in Combination With Everolimus and Exemestane in Women With Hormone Receptor Positive and HER2-negative Breast Cancer That Has Spread
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Xentuzumab|DRUG: Placebo|DRUG: Everolimus|DRUG: Exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Assess the Long-term Safety of Octreotide Subcutaneous Depot in Patients With Acromegaly
Status: ACTIVE_NOT_RECRUITING
Conditions: Acromegaly
Interventions: DRUG: CAM2029 (octreotide subcutaneous depot)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaping High vs. Low Nicotine E-Liquid
Status: WITHDRAWN
Conditions: Cardiovascular Risk Factor|Nicotine Dependence
Interventions: OTHER: Low Nicotine E-Liquid|OTHER: Medium or High Nicotine E-Liquid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PK Study of Rifampicin Interactions With DMPA and Efavirenz in TB
Status: COMPLETED
Conditions: HIV-1 Infection|Tuberculosis
Interventions: DRUG: Depot medroxyprogesterone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of the EMG-driven Hand Robot Training in Patients With Hand Dysfunction Due to Nerve Damage From Burns
Status: RECRUITING
Conditions: Burn Hand|Rehabilitation
Interventions: OTHER: EMG-driven hand robot training|OTHER: conventional occupational training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immune Profile Analysis and Biomarker Identification in Women With Repeated Implantation Failure or Unexplained Recurrent Spontaneous Miscarriage
Status: RECRUITING
Conditions: Repeated Embryo Implantation Failure|Recurrent Miscarriage|Immune System
Interventions: BIOLOGICAL: blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Rosiglitazone Versus Rosiglitazone and Metformin Versus Rosiglitazone and Avandia in the Treatment of Nonalcoholic Steatohepatitis (NASH)
Status: UNKNOWN
Conditions: Nonalcoholic Steatohepatitis|Nonalcoholic Fatty Liver Disease
Interventions: DRUG: avandia|DRUG: metformin|DRUG: losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose-defining Study of OPC-41061 in Treatment of Hepatic Edema
Status: COMPLETED
Conditions: Cirrhosis
Interventions: DRUG: OPC-41061 7.5mg|DRUG: OPC-41061 placebo|DRUG: OPC-41061 15mg|DRUG: OPC-41601 30mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term Follow-up of Comparison of Clopidogrel vs. Aspirin Monotherapy After Drug-eluting Stent Implantation
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease|Atheroscleroses, Coronary
Interventions: DRUG: Antiplatelet Agents
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nebulized Dexmedetomidine VS ODF Melatonin for Peri Operative Anxiety and Emergence Agitation in Pediatric Day Surgery
Status: RECRUITING
Conditions: Anxiety Acute|Emergence Agitation
Interventions: DRUG: Dexmedetomidine|DRUG: Melatonin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy Study of Huatuo Zaizao Pills in Improving of Neural Function in Acute Ischemic Stroke
Status: UNKNOWN
Conditions: Ischemic Stroke
Interventions: DRUG: Huatuo Zaizao Pills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy and Safety of IW-6118 in Patients Undergoing Third Molar Extraction
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: IW-6118|DRUG: Matching Placebo|DRUG: Naproxen Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CiNPT for Abdominoplasties in Post-bariatric Patients Study
Status: UNKNOWN
Conditions: Obesity, Morbid|Obesity|Obesity, Abdominal|Wound|Wound Infection|Wound Complication|Wound Dehiscence|Wound Contamination|Wound Heal|Wound; Abdomen|Incision|Incision Site Rash|Incision Site Bleeding|Incision Site Swelling|Incision Site Haematoma|Incision Site Infection|Incision Site Inflammation|Incision Site Complication|Incision Surgical|Surgery--Complications|Surgical Wound Infection|Surgical Site Infection|Scarring as Surgical Complication|Scar|Scarring
Interventions: DEVICE: ciNPT group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multımedia Information Before Amniocentesıs And Chorion Villus Sampling
Status: NOT_YET_RECRUITING
Conditions: Amniocentesis|Chorionic Villus Sampling
Interventions: BEHAVIORAL: Multimedia information training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Anastrozole in Patients With Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Anastrozole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Open Wide Excision Versus Minimal Surgery for Pilonidal Disease
Status: COMPLETED
Conditions: Pilonidal Disease
Interventions: PROCEDURE: open wide-excision pilonidal cystectomy|PROCEDURE: minimal invasive pilonidal cystotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: MRI Scans of Blood Vessel Changes Caused by Bevacizumab Alone or Given Together With Interferon Alpha-2a in Treating Patients With Stage III or Stage IV Kidney Cancer
Status: UNKNOWN
Conditions: Kidney Cancer
Interventions: BIOLOGICAL: bevacizumab|BIOLOGICAL: recombinant interferon alpha-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of DNL126 in Pediatric Participants With Mucopolysaccharidosis Type IIIA (Sanfilippo Syndrome Type A)
Status: RECRUITING
Conditions: Mucopolysaccharidosis Type IIIA
Interventions: DRUG: DNL126
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Entolimod in Treating Patients With Locally Advanced or Metastatic Solid Tumors That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: entolimod|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of Intensive and Distributed CIMT on Upper Extremity Function in Stroke Patients
Status: RECRUITING
Conditions: Stroke
Interventions: OTHER: Intensive constraint-induced movement therapy|OTHER: Distributed constraint-induced movement therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Increasing Human Papillomavirus (HPV) Vaccine Uptake Via General Health Messaging
Status: COMPLETED
Conditions: Human Papilloma Virus
Interventions: BEHAVIORAL: Health Messaging via SMS|BEHAVIORAL: CDC Health Pamphlets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Modified Rapid Sequence Induction in Morbidly Obese Patients
Status: WITHDRAWN
Conditions: Anesthesia Intubation Complication
Interventions: PROCEDURE: Rapid sequence induction t-RSI|PROCEDURE: Rapid sequence induction m-RSI-PEEP|PROCEDURE: Rapid sequence induction m-RSI-vent|PROCEDURE: m-RSI-vent-cric|PROCEDURE: Cricoid Pressure|DRUG: Anesthetics|DIAGNOSTIC_TEST: Aspiration of gastric air via nasogastric tube|DIAGNOSTIC_TEST: Impression of gastric inflation at laparoscopy.|DIAGNOSTIC_TEST: Arterial blood gas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SAL-0951 Tablets in the Treatment of Renal Anemia in Non-dialysis Chronic Kidney Disease
Status: COMPLETED
Conditions: Renal Anemia in Non-dialysis Chronic Kidney Disease
Interventions: DRUG: SAL-0951|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Capmatinib and Spartalizumab/Placebo in Advanced NSCLC Patients With MET Exon 14 Skipping Mutations
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Spartalizumab|DRUG: Capmatinib|DRUG: spartalizumab placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound First Clinical Decision Support for Suspected Nephrolithiasis
Status: COMPLETED
Conditions: Nephrolithiasis
Interventions: BEHAVIORAL: Ultrasound-first Clinical Decision Support tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Restoring Neural Oscillatory Communication in Developmental Dyslexia
Status: RECRUITING
Conditions: Developmental Dyslexia
Interventions: DEVICE: Parietal tACS combined with visuo-attentional training|DEVICE: Sham (placebo) tACS combined with visuo-attentional training|DEVICE: Sham (placebo) tACS combined with phonics training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ultrasound-Guided Hip Joint Cooled Radiofrequency Denervation
Status: WITHDRAWN
Conditions: Hip Osteoarthritis|Chronic Pain
Interventions: DEVICE: Ultrasound-Guided Cooled Radiofrequency Hip Denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Travoprost APS Versus TRAVATAN
Status: COMPLETED
Conditions: Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Travoprost 0.004% (POLYQUAD-preserved) Eye Drops, Solution|DRUG: Travoprost 0.004% (BAK-preserved) Eye Drops, Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Validation of CD Diagnostics Synovasure PJI ELISA Test and Synovasure PJI Lateral Flow Test for Detection of Periprosthetic Joint Infection in Synovial Fluid
Status: UNKNOWN
Conditions: Periprosthetic Joint Infection
Interventions: DEVICE: Synovasure PJI Lateral Flow test and Synovasure PJI ELISA Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study To Evaluate Long Term Maintenance With TRIZIVIR After Boosted Protease Inhibitor (PI) Or Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) In HIV-1 Infected Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: TRIZIVIR|DRUG: Non-nucleoside reverse transcriptase inhibitor|DRUG: Boosted Protease Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BettER: Biomarker Driven Early Therapeutic Selection in Patients With HR+ HER2- Metastatic or Unresectable Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Metastatic Breast Cancer|Unresectable Breast Cancer
Interventions: DEVICE: DiviTum® TKa assay|DRUG: CDK4/6 + Endocrine therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Therapy for Resectable Pancreatic Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Pancreas|Stage IA Pancreatic Cancer|Stage IB Pancreatic Cancer|Stage IIA Pancreatic Cancer|Stage IIB Pancreatic Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: docetaxel|DRUG: capecitabine|RADIATION: intensity-modulated radiation therapy|DRUG: oxaliplatin|PROCEDURE: pancreatic surgical procedure|PROCEDURE: therapeutic conventional surgery|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Techniques of Locoregional Analgesia in Total Knee Prosthesis Surgery : Block to the Adductor Channel Versus Peri-articular Local Infiltrations
Status: COMPLETED
Conditions: Analgesic
Interventions: DRUG: locoregional analgesia by a block on the adductor channel|DRUG: locoregional analgesia by periarticular local infiltrations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Xperience™ vs Normal Saline Irrigation Solution for Decreasing Bioburden After Primary Total Hip and Knee Arthroplasty
Status: WITHDRAWN
Conditions: Total Knee Replacement Surgery|Total Hip Replacement Surgery
Interventions: DEVICE: XPERIENCE Advanced Surgical Irrigation|OTHER: Standard of Care Irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Virtual Reality on Pain, Fear and Anxiety During Blood Draw in Children Aged 5-12 Years Old
Status: COMPLETED
Conditions: Pain|Anxiety State|Fear|Child, Only
Interventions: BEHAVIORAL: Children watch applications by wearing the virtual headset during the blood draw.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Testing the Effects of Oxybutynin for the Treatment of Hot Flashes in Men Receiving Hormone Therapy for Prostate Cancer
Status: COMPLETED
Conditions: Prostate Carcinoma
Interventions: DRUG: Oxybutynin Chloride|DRUG: Placebo Administration|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Loratadine for Prevention of Pegfilgrastim-Induced Pain
Status: UNKNOWN
Conditions: Pegfilgrastim-induced Back and Leg Pain
Interventions: DRUG: Loratadine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Study to Evaluate the Efficacy of an Anti-Aging Serum
Status: COMPLETED
Conditions: Fine Lines|Wrinkle|Photoaging
Interventions: OTHER: Anti-aging Serum|OTHER: Facial Moisturizer|OTHER: Cleansing Lotion|OTHER: Sunscreen|OTHER: Sunscreen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Placebo-Controlled, Cross-Over Trial of Aripiprazole
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Aripiprazole|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Proton Radiotherapy for Retroperitoneal Sarcoma
Status: TERMINATED
Conditions: Retroperitoneal Sarcoma
Interventions: RADIATION: Preoperative proton therapy|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metabolic Effects of Exogenous 3-hydroxybutyrate in Patients With Type 1 Diabetes and Healthy Controls
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus|Diabetic Ketoacidosis
Interventions: BIOLOGICAL: 3-hydroxybutyrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate LY01011 and Xgeva® in Healthy Adults
Status: UNKNOWN
Conditions: Healthy Adults
Interventions: DRUG: LY01011|DRUG: Xgeva 120 MG in 1.7 ML Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sutures Versus Staples for Wound Closure in Orthopaedic Surgery
Status: COMPLETED
Conditions: Surgical Wound Infection
Interventions: DEVICE: Sutures|DEVICE: Staples
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: rhTPO Combining Rituximab Versus Low-dose Rituximab in Management of ITP
Status: COMPLETED
Conditions: Purpura|Idiopathic Thrombocytopenic Purpura
Interventions: DRUG: rituximab; recombinant human thrombopoietin (rhTPO)|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Prednisolone in Combination With SPI-62 in Participants With Polymyalgia Rheumatica (PMR)
Status: SUSPENDED
Conditions: Polymyalgia Rheumatica
Interventions: DRUG: Prednisolone|DRUG: SPI-62
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Therapy in Treating Patients With Precancerous Esophageal Conditions or Early Stage Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer|Precancerous Condition
Interventions: DRUG: HPPH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Clinical Trial on the Efficacy of Two Carnitine-Based Products on Muscle Function in Healthy Older Adults
Status: COMPLETED
Conditions: Muscle Function
Interventions: DIETARY_SUPPLEMENT: Carnipure Product 1|DIETARY_SUPPLEMENT: Carnipure Product 2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Safety and Efficacy of Adalimumab Versus Ustekinumab for One Year
Status: COMPLETED
Conditions: Crohn Disease
Interventions: BIOLOGICAL: Placebo for Ustekinumab|BIOLOGICAL: Placebo for Adalimumab|BIOLOGICAL: Ustekinumab (6 mg/kg)|BIOLOGICAL: Ustekinumab (90 mg)|BIOLOGICAL: Adalimumab (40 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Right Ventricular Diastolic Function in Chronic Adverse RV Loading And Congenital Heart Disease
Status: UNKNOWN
Conditions: Pulmonary Regurgitation|Congenital Heart Disease
Interventions: DIAGNOSTIC_TEST: Acquisition of pressure-volume-loops
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Faecal Bacteriotherapy for Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: OTHER: Faecal bacterial transplantation|DRUG: Mesalazine 4G Enema
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can 3D Laparoscopy Improve Surgical Performances in Surgeons in Training?
Status: UNKNOWN
Conditions: Uterine Fibroid|Uterine Bleeding|Uterine Prolapse
Interventions: OTHER: 0° 3D laparoscopy high-definition camera(Olympus Winter & IBE GMBH, Hamburg - Germany)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Post Approval Commitment Study to Gain More Information on How Safe and Effective KOVALTRY is in Chinese Children, Adolescents /Adults With Severe Hemophilia A
Status: COMPLETED
Conditions: Hemophilia A
Interventions: BIOLOGICAL: Recombinant Factor VIII (Kovaltry, BAY81-8973) Treatment Group 1|BIOLOGICAL: Recombinant Factor VIII (Kovaltry, BAY81-8973) Treatment Group 2|BIOLOGICAL: Recombinant Factor VIII (Kovaltry, BAY81-8973) Treatment Group 3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Different Orthodontic Tooth Movements Assisted With Injectable Platelet Rich Fibrin
Status: ENROLLING_BY_INVITATION
Conditions: Effect of Platelet Rich Fibrin With Different Tooth Movements
Interventions: BIOLOGICAL: injectable platelet rich fibrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE