pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety, Tolerability and Pharmacokinetics of Efavirenz in HIV-Infected Children
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Efavirenz (EFV) + Didanosine (ddI) + Emtricitabine (FTC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of SHR-1918 in Patients With Homozygous Familial Hypercholesterolemia
Status: NOT_YET_RECRUITING
Conditions: Homozygous Familial Hypercholesterolemia
Interventions: DRUG: SHR-1918
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Propranolol During Prostatectomy to Decrease Cancer Recurrence
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Propranolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Electroacupuncture Analgesia for Colonoscopy
Status: COMPLETED
Conditions: Pain
Interventions: PROCEDURE: Electroacupuncture|PROCEDURE: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Normal Range of Superior Mesenteric Artery in Young Chinese Population and Its Correlation With Retroperitoneal Adipose Tissue
Status: COMPLETED
Conditions: Aortomesenteric Angle|Aortomesenteric Distance|Retroperitoneal Adipose Tissue
Interventions: DIAGNOSTIC_TEST: computerized tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Semaglutide Therapy for Alcohol Reduction (STAR)
Status: RECRUITING
Conditions: Addiction|Alcohol Use Disorder
Interventions: BEHAVIORAL: Take Control|DRUG: Semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Solriamfetol in the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Fatigue Syndrome|Myalgic Encephalomyelitis
Interventions: DRUG: Solriamfetol Oral Tablet [Sunosi]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Modulating Auditory Symptoms and Vertigo of Meniere's Disease by Non-invasive Mastoid Electric Stimulation
Status: RECRUITING
Conditions: Meniere's Disease
Interventions: DEVICE: YPS-201b|DRUG: betahistine|DEVICE: YPS-201b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PT886 For Treatment of Patients With Metastatic/Advanced Gastric, Gastroesophageal Junction and Pancreatic Adenocarcinoma (the TWINPEAK Study)
Status: RECRUITING
Conditions: Gastric or Gastroesophageal Junction Adenocarcinoma|Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: PT886|DRUG: Paclitaxel|DRUG: Gemcitabine|DRUG: Abraxane|DRUG: KEYTRUDA® (pembrolizumab)|DRUG: Oxaliplatin|DRUG: Leucovorin|DRUG: Fluorouracil|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simultaneous Versus Sequential Use of Adjuvant Chemotherapy and GnRHa in Treating ER+,Premenopausal Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Zoladex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Pulsed Electromagnetic Fields (PEMFS) On Cerebral Haemodynamics
Status: TERMINATED
Conditions: Cerebral Hemodynamics|Cognitive Change
Interventions: DEVICE: Pulsed Electromagnetic Fields Therapy (Dominant leg)|DEVICE: Pulsed Electromagnetic Fields Therapy (Non-dominant leg)|DEVICE: Sham Therapy (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Two Way Cross Over Pharmacokinetic Interaction Study Between Raltegravir and Amlodipine in Healthy Volunteers
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Raltegravir|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Kidney Histopathology in Obstructive Jaundice
Status: COMPLETED
Conditions: Patients With Obstructive Jaundice
Interventions: PROCEDURE: Whipple operation,Hepaticojejunostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Holmium Laser and Thulium Laser for Mini PCNL
Status: ENROLLING_BY_INVITATION
Conditions: Nephrolithiasis|Percutaneous Nephrolithotomy
Interventions: DEVICE: Holmium Laser|DEVICE: Thulium Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Drug Interaction Study Evaluating GSK2248761 and Raltegravir Pharmacokinetics in Healthy Adult Subjects
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: Raltegravir|DRUG: GSK2248761|DRUG: GSK2248761 + Raltegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Allogeneic Bone Marrow Transplantation Using Matched, Related Donors in Patients With Nonmalignant Hematologic Disorders
Status: COMPLETED
Conditions: Neutropenia|Sickle Cell Anemia|Thalassemia Major|Red-Cell Aplasia, Pure
Interventions: DRUG: anti-thymocyte globulin|DRUG: busulfan|DRUG: cyclophosphamide|PROCEDURE: Bone marrow transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Efficacy of Ang-(1-7) to Enhance Cognitive Function in Participants Undergoing CABG
Status: SUSPENDED
Conditions: Coronary Artery Bypass Surgery|Cognitive Impairment
Interventions: DRUG: Angiotensin-(1-7)|DRUG: Placebo for Angiotensin-(1-7)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gene Therapy Follow up Protocol for Subjects Previously Enrolled in NCI Center for Immuno-Oncology Studies
Status: ENROLLING_BY_INVITATION
Conditions: Cervical Intraepithelial Neoplasia|Cervical Neoplasms|Oropharyngeal Neoplasms|Squamous Intraepithelial Lesions of the Cervix|Hematologic Malignacies
Interventions: DRUG: GeneTherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Intestinal Microbiota Manipulation to Treat Resistant Hypertension
Status: UNKNOWN
Conditions: Hypertension|Resistant Hypertension
Interventions: DIETARY_SUPPLEMENT: Prebiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Intra-hepatic Artery Bone Marrow Derived Stem Cells Infusion for the Treatment of Advanced Liver Cirrhosis
Status: UNKNOWN
Conditions: End Stage Liver Disease
Interventions: BIOLOGICAL: Stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ferroptosis in Patients With COPD COPD With/Without Risk of Cardiovascular Events. Pathophysiological Implications, Diagnostics and Prognoses. FerrEPOC Study.
Status: RECRUITING
Conditions: COPD Exacerbation
Interventions: OTHER: Non-interventional study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of XP12B in Women With Menorrhagia
Status: COMPLETED
Conditions: Menorrhagia|Heavy Menstrual Bleeding
Interventions: DRUG: Tranexamic acid tablets|DRUG: Tranexamic acid tablets|DRUG: Placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improved HRV, Inflammation Markers and Endothelial Function After TAVI
Status: COMPLETED
Conditions: Severe Aortic Stenosis|TAVI
Interventions: DIAGNOSTIC_TEST: Flow mediated vasodilatation|DIAGNOSTIC_TEST: High resolution ECG|DIAGNOSTIC_TEST: Blood withdrawal
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Tislelizumab Plus Chemotherapy vs Chemotherapy as Perioperative Treatment in Participants With HER2 Negative Breast Cancer
Status: UNKNOWN
Conditions: HER2-negative Breast Cancer
Interventions: BIOLOGICAL: Tislelizumab|DRUG: Nab paclitaxel|DRUG: Doxorubicin|DRUG: Epirubicin|DEVICE: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A China Bridging Study of Ivosidenib in r/r AML Subjects With an IDH1 Mutation
Status: COMPLETED
Conditions: Relapsed or Refractory Acute Myeloid Leukemia
Interventions: DRUG: ivosidenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medical Abortion at Gestational Age of 8 to ≤9 Weeks Versus >9 to ≤12 Weeks
Status: UNKNOWN
Conditions: Medical Abortion
Interventions: DRUG: Mifepristone|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Air Polishing With Ultrasonic Debridement in the Treatment of Initial Periodontal Pockets
Status: COMPLETED
Conditions: Gingivitis
Interventions: DEVICE: Electro Medical Systems AIRFLOW®|DEVICE: Electro Medical Systems Piezo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Long Term Dietary Portfolio and of Sequential Removal of Food Components From the Diet
Status: COMPLETED
Conditions: Hyperlipidemia|Cardiovascular Diseases|Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: Dietary portfolio of cholesterol-lowering foods
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aerobic Training in Post-MI Patients With DPN
Status: COMPLETED
Conditions: Myocardial Infarction|Diabetes Mellitus, Type 2|Diabetic Peripheral Neuropathy
Interventions: OTHER: Exercise based-cardiac rehabilitation (EB-CR) program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluating the Efficacy of Neratinib on Live Cell HER2 Signaling Transduction Analysis Positive Triple Negative Breast
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple Negative Breast Cancer|Early-stage Breast Cancer|HER2-positive Breast Cancer
Interventions: DRUG: Neratinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Spinal/Epidural (CSE) Saline Duration/Spread
Status: TERMINATED
Conditions: Labor Pain
Interventions: OTHER: Sterile normal saline 0 mls|OTHER: 15 mls sterile normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Outpatient Foley Catheter Compared to Usual Inpatient Care for Labor Induction
Status: TERMINATED
Conditions: Pregnancy
Interventions: DEVICE: Foley catheter|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Dexmedetomidine on cTnI and GP-BB in Patients Undergoing OPCABG
Status: UNKNOWN
Conditions: Coronary Artery Bypass, Off-Pump
Interventions: DRUG: dexmedetomidine|OTHER: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Observational Chart Review Study To Describe The Real-World Outcomes And Use Of Avelumab In Combination With Axitinib For Treatment Of Patients With aRCC In The UK
Status: COMPLETED
Conditions: Advanced Renal Cell Carcinoma
Interventions: DRUG: avelumab|DRUG: axitinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Deep Neuromuscular Blockade During Robotic Radical Prostatectomy
Status: UNKNOWN
Conditions: Neuromuscular Blockade
Interventions: DRUG: Standard neuromuscular blockade|DRUG: Deep neuromuscular blockade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence (BE) Study of TAK-438 Orally Disintegrating (OD) Tablet
Status: COMPLETED
Conditions: Japanese Healthy Adult Male
Interventions: DRUG: TAK-438 OD|DRUG: TAK-438
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Non-Healing Ulcers Without Critical Limb Ischemia
Status: UNKNOWN
Conditions: Peripheral Artery Disease Without Critical Limb Ischemia
Interventions: PROCEDURE: Angioplasty of the lower limbs vessels
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Statin Therapy in Prevention of Anthracycline-Induced Cardiotoxicity
Status: RECRUITING
Conditions: Doxorubicin Induced Cardiomyopathy
Interventions: DRUG: Atorvastatin 40 Mg Oral Tablet|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Oxaliplatin, Gemcitabine and Bevacizumab in Women With Recurrent Mullerian Carcinoma
Status: TERMINATED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Cancer
Interventions: DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of R1507 in Combination With Multiple Standard Chemotherapy Treatments in Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Neoplasms
Interventions: DRUG: RG1507|DRUG: RO1507|DRUG: bevacizumab [Avastin]|DRUG: capecitabine [Xeloda]|DRUG: carboplatin|DRUG: cetuximab|DRUG: docetaxel|DRUG: erlotinib [Tarceva]|DRUG: etoposide|DRUG: gemcitabine|DRUG: irinotecan|DRUG: mFOLFOX6|DRUG: paclitaxel|DRUG: pemetrexel|DRUG: sorafenib|DRUG: temozolomide|DRUG: trastuzumab [Herceptin]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OCT in Borderline Coronary Artery Lesions
Status: COMPLETED
Conditions: Optical Coherence Tomography (OCT)|Percutaneous Coronary Intervention (PCI)|Single-Photon Emission Computed Tomography (SPECT)|Coronary Angiography (CAG)|Borderline Coronary Artery Lesions
Interventions: DIAGNOSTIC_TEST: OCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measurement of Heart-carotid Pulse Wave Velocity (hcPWV) by Laser Doppler Vibrometry (LDV)
Status: NOT_YET_RECRUITING
Conditions: Hypertension|Aortic Aneurysm|Bicuspid Aortic Valve|Marfan Syndrome|Aortic Dilatation
Interventions: DEVICE: Laser doppler vibrometry (LDV), heart(cordium) carotid pulse wave velocity (ccPWV)|PROCEDURE: Blood pressure and heart rate measurement|DEVICE: carotid to femoral PWW measurement|PROCEDURE: Questionnaire completion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Gui-Lu-Er-Xian-Jiao-Wan on Intradialytic Hypotension
Status: NOT_YET_RECRUITING
Conditions: Intradialytic Hypotension
Interventions: DRUG: Gui-Lu-Er-Xian-Jiao-Wan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of ALS-L1023 in Subjects With NASH
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis
Interventions: DRUG: Placebo oral tablet|DRUG: ALS-L1023 1,200mg|DRUG: ALS-L1023 1,800mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Discharge Education Based on Roy Adaptation Model on Palliative Care Patients and Caregivers
Status: NOT_YET_RECRUITING
Conditions: Nurse's Role|Nutritional Deficiency|Adaptation Reaction
Interventions: OTHER: Discharge training based on Roy adaptation model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase IIb Study of Nabiximols for Spasticity Due to Neuromyelitis Optica Spectrum Disorders
Status: NOT_YET_RECRUITING
Conditions: NMO Spectrum Disorder|Spasticity, Muscle
Interventions: DRUG: Nabiximols|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CAN BREATHE in COPD Trial
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease (COPD)|Breathlessness|Exercise Intolerance
Interventions: DRUG: Cannabis|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Effects of the Organism on Monomethyl Fumarate (MMF) After the Administration of LAS41008
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: LAS41008 120 mg / Fumaderm® 120 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: dexamethasone|DRUG: pegylated liposomal doxorubicin hydrochloride|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effects of Caffeine on Human Spinal Motoneurons
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Coffee|DIETARY_SUPPLEMENT: Decaffeinated coffee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Radiation Therapy, Palbociclib, and Hormone Therapy in Treating Breast Cancer Patients With Bone Metastasis
Status: COMPLETED
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Estrogen Receptor Positive|HER2/Neu Negative|Metastatic Breast Carcinoma|Metastatic Malignant Neoplasm in the Bone|Progesterone Receptor Positive|Prognostic Stage IV Breast Cancer AJCC v8
Interventions: DRUG: Anastrozole|DRUG: Exemestane|DRUG: Fulvestrant|DRUG: Letrozole|DRUG: Palbociclib|RADIATION: Radiation Therapy|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sphenopalatine Ganglion Block to Treat Shoulder Pain After Thoracotomy
Status: COMPLETED
Conditions: Ipsilateral Shoulder Pain
Interventions: PROCEDURE: Sphenopalatine Ganglion (SPG) Block|DRUG: lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thoracic Fluid Assessment by Contrast-enhanced Magnetic Resonance Imaging and Bioimpedance
Status: COMPLETED
Conditions: Pulmonary Congestion
Interventions: DEVICE: MRI|DRUG: Gd-CA|DEVICE: BIS ImpediMed™ SFB7|DEVICE: Autotransfusion Lympamat Digital Gradient system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Evogliptin add-on to Metformin in Patients With type2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: evogliptin|DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Opioid Free Anesthesia and Major Spine Surgery
Status: COMPLETED
Conditions: Opioid Use|Postoperative Pain|Spine Disease
Interventions: DRUG: opioid free Anesthesia vs Opioid based Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of an Oral Probiotic Intervention With or Without a Novel ADP-1 Toothpaste
Status: COMPLETED
Conditions: Oral Health
Interventions: DIETARY_SUPPLEMENT: Oral probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Phytin on Human Gut Microbiome (EPoM)
Status: COMPLETED
Conditions: Diet Modification
Interventions: DIETARY_SUPPLEMENT: Phytin, rice extract|OTHER: MCC, placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Construction and External Validation of a Predictive Clinico-biological Score of the Risk of Venous Thrombosis in Women Under Combined Oral Contraceptives
Status: UNKNOWN
Conditions: Venous Thromboembolism
Interventions: BIOLOGICAL: blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Paravertebral Block and Erector Spinae Plane Block on Intraoperative Opioid Consumption Using NoL Index
Status: NOT_YET_RECRUITING
Conditions: Postoperative Pain|Opioid Use
Interventions: PROCEDURE: Paravertebral block|PROCEDURE: Erector spiane plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Pharmacodynamics of the Interferon Beta-1a Produced by Laboratorio Quimico Farmaceutico Bergamo Compared to Interferon Beta-1a (Rebif - Merck Serono) in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Interferon beta-1a|BIOLOGICAL: Interferon beta-1a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A 10-12 Week Study to Evaluate the Safety and Efficacy of 320 mg Valsartan and 80 mg Simvastatin in Combination and as Monotherapies in Treating Hypertension and Hypercholesterolemia
Status: COMPLETED
Conditions: HYPERTENSION|HYPERCHOLESTEROLEMIA
Interventions: DRUG: valsartan + simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Proton Beam Radiotherapy Followed by Tecentriq and Avastin for Primary Liver Cancer With Vp2-4 Portal Vein Invasion
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Portal Vein Thrombosis
Interventions: RADIATION: PBT and atezolizumab/bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET Imaging of Cancer Patients Using 124I-PUH71: A Pilot Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Hodgkin's Lymphoma|Myeloma|Active Solid Malignancy
Interventions: DRUG: PET Imaging using 124 IPUH71
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy Evaluation of CO2 Removal in Combination With Continuous Veno-Venous Hemodialysis/Hemodiafiltration Therapy
Status: RECRUITING
Conditions: Acute Lung Injury|Acute Kidney Injury|Hypercapnia|Covid19
Interventions: DEVICE: multiECCO2R blood-gas exchanger
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tafasitamab Plus Lenalidomide in Relapsed CNS Lymphoma
Status: RECRUITING
Conditions: CNS Lymphoma|Primary Central Nervous System Lymphoma|Secondary Central Nervous System Lymphoma
Interventions: DRUG: Tafasitamab|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Long-term Extension Study to Assess the Long-term Safety and Efficacy of Pegtibatinase Treatment in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU)
Status: ENROLLING_BY_INVITATION
Conditions: Homocystinuria
Interventions: DRUG: Pegtibatinase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ph 1 Trial of ADI PEG 20 Plus Sorafenib to Treat Patients With Liver Cancer
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: ADI-PEG 20
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Micronutrient Supplementation on Nerve Conduction Velocity in T1D- RCT
Status: RECRUITING
Conditions: Type 1 Diabetes
Interventions: DIETARY_SUPPLEMENT: Tablet VitaBliss vitamin B12 (2.2 mcg)|DIETARY_SUPPLEMENT: Tablet VitaBliss vitamin B12 (2.2 mcg) and Syrup Orofer (5 ml = 50 mg)|DIETARY_SUPPLEMENT: Tablet VitaBliss vitamin B12 (2.2 mcg) and Tablet Tayo (60000 IU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Anlotinib or Penpulimab in Combination With RAI for DTC
Status: UNKNOWN
Conditions: Thyroid Cancer
Interventions: DRUG: Anlotinib hydrochloride|DRUG: Sodium Iodide I 131|DRUG: Penpulimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Postvitrectomy Proactive Use of Conbercept on Postoperative Complications in PDR Patients
Status: RECRUITING
Conditions: Proliferative Diabetic Retinopathy
Interventions: DRUG: proactive Anti-VEGF (conbercept) use|DRUG: passive Anti-VEGF (conbercept) use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Prophylactic Clip Application for the Prevention of Postpolypectomy Bleeding in Pedunculated Colonic Polyps
Status: COMPLETED
Conditions: Bleeding
Interventions: PROCEDURE: Prophylactic clip|PROCEDURE: No prophylactic management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Traditional Chinese Medicine on Outcomes in Patients With AECOPD Risk Window
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: TCM granule plus conventional drug|DRUG: TCM placebo granule plus conventional drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Primary Care Provider Supply and Patient Outcomes
Status: COMPLETED
Conditions: Health Services Accessibility|Health Behavior|Health Care Quality, Access, and Evaluation
Interventions: OTHER: Physician|OTHER: Mid-level provider|BEHAVIORAL: Conditional Cash Transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An Assessment of Rapid Streptococcal Tests in Community Clinics in Israel
Status: COMPLETED
Conditions: Pharyngitis|Streptococcus Pyogenes Infection|Streptococcus Pyogenes Identification
Interventions: DEVICE: rapid streptococcal testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Bilirubin Measurements in Newborns From Smartphone Digital Images in a Population in Botswana
Status: COMPLETED
Conditions: Jaundice, Neonatal
Interventions: DEVICE: Picterus Jaundice Pro
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Heel Warming Before Capillary Blood Sampling
Status: COMPLETED
Conditions: Blood Specimen Collection
Interventions: PROCEDURE: Heating with a disposable glove containing water|PROCEDURE: Heating with a blanket|PROCEDURE: Heating with a gel pack
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Role of Expectations in Response to Caffeine Consumption: An RCT
Status: COMPLETED
Conditions: Caffeine|Affect|Cognitive Ability, General|Mood
Interventions: DRUG: Caffeine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Drug Combinations of Atovaquone-Proguanil (AP) With ACT
Status: UNKNOWN
Conditions: Plasmodium Falciparum Malaria (Drug Resistant)
Interventions: DRUG: Artesunate and Pyronaridine|DRUG: Atovaquone Proguanil and Artesunate Pyronaridine|DRUG: Atovaquone Proguanil and Artesunate Mefloquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preimplantation Genetic Diagnosis for the Indication of Advanced Reproductive Age
Status: SUSPENDED
Conditions: Infertility
Interventions: PROCEDURE: Preimplantation Genetic Diagnosis (PGD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Validation of Uncalibrated Cardiac Output Measurement With LiDCOrapid in the Resuscitation of Critically Ill Patients With Septic Shock: A Prospective Cross-sectional Study.
Status: COMPLETED
Conditions: Cardiac Output, LIDCO Rapid, Septic Shock
Interventions: OTHER: fluid resuscitation with crystalloid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pediatric Open-Label Extension Study
Status: COMPLETED
Conditions: Schizophrenia|Autism|Bipolar Depression
Interventions: DRUG: Lurasidone 20, 40, 60, 80 mg, flexibly dosed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Osimertinib Treatment on EGFR T790M Plasma Positive NSCLC Patients (APPLE)
Status: ACTIVE_NOT_RECRUITING
Conditions: NSCLC
Interventions: DRUG: Osimertinib|DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PDA Stent in Neonates With PDA Dependent Pulmonary Circulation
Status: RECRUITING
Conditions: Neonatal Cyanosis Due to PDA Dependent Pulmonary Circulation
Interventions: DEVICE: Catheter-guided PDA stent implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Icatibant in Patients With Acute Attacks of Hereditary Angioedema (FAST-3)
Status: COMPLETED
Conditions: Hereditary Angioedema
Interventions: DRUG: Icatibant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EBUS Guided Cryo Biopsy of Solitary Pulmonary Nodules
Status: UNKNOWN
Conditions: Yield of Cryo Biopsy in Lung Cancer|Solitary Pulmonary Nodule
Interventions: PROCEDURE: Cryo biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Internet-Based Cognitive Behavioral Therapy for Treating Mothers With Depression
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Cognitive behavioral therapy (CBT)|OTHER: Treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fed Study of Rabeprazole Sodium Tablets 20 mg and Aciphex® Tablets 20 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rabeprazole Sodium Tablets 20 mg|DRUG: Aciphex® Tablets 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Hansenula-Derived Pegylated-Interferon Alpha-2a in Egyptian Children With Chronic HCV
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Reiferon R|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of DLL3-CAR-NK Cells in the Treatment of Extensive Stage Small Cell Lung Cancer
Status: UNKNOWN
Conditions: SCLC, Extensive Stage
Interventions: BIOLOGICAL: DLL3-CAR-NK cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterizing Iodine-124 Evuzumitide (AT-01) in Systemic Amyloidosis
Status: RECRUITING
Conditions: Amyloidosis|Transthyretin Amyloidosis
Interventions: DIAGNOSTIC_TEST: 124I-Evuzamitide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Transpulmonary Thermodilution and Transesophageal Echocardiography in Early Septic Shock
Status: COMPLETED
Conditions: Septic Shock
Interventions: COMBINATION_PRODUCT: early septic shock
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A First Time in Man Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD1979 in Healthy Males
Status: TERMINATED
Conditions: Healthy Subjects
Interventions: DRUG: AZD1979|DRUG: Placebo to match
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: You & Me Healthy: Youth Empowered Self-Care Substudy (YES)
Status: ACTIVE_NOT_RECRUITING
Conditions: Anxiety|Wellness, Psychological
Interventions: BEHAVIORAL: Community-based recreation program referral|BEHAVIORAL: Pre-surveys only
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Cognitive Effects of Two Exergame Training and Traditional Training in Patients With Chronic Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Wii Fit(30 Mins)|DEVICE: Tetrax biofeedback(30 Mins)|OTHER: Conventional weight-shifting(30 Mins)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Vehicle Controlled Study to Evaluate Safety and Efficacy of Topical TMB-001 for Treatment of Congenital Ichthyosis
Status: COMPLETED
Conditions: Congenital Ichthyosis
Interventions: DRUG: Isotretinoin|OTHER: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PK Study of Liquid Formulation of BIO89-100 in Subjects With NASH With Compensation Cirrhosis
Status: COMPLETED
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: DRUG: BIO89-100
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Genetic Variants in MATE1 and OCT3 on the Pharmacodynamics of Metformin in African Americans
Status: COMPLETED
Conditions: Healthy|Type 2 Diabetes Mellitus
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Laparoscopically Guided Rectus Sheath Block in Pediatric Appendicitis
Status: COMPLETED
Conditions: Appendicitis Acute
Interventions: DRUG: Rectus Sheath Block with 0.25% bupivicaine with 1:200 000 epinephrine|PROCEDURE: Local Anesthetic Infiltration with 0.25% bupivicaine with 1:200 000 epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study of ADI-001 in Lupus Nephritis
Status: NOT_YET_RECRUITING
Conditions: Lupus Nephritis|Autoimmune Diseases
Interventions: DRUG: ADI-001|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Affective Responses During Continuous and Interval Exercise
Status: RECRUITING
Conditions: Health Behavior
Interventions: OTHER: Continuous exercise at an intensity below the ventilatory threshold|OTHER: Continuous exercise at an intensity at the ventilatory threshold|OTHER: Continuous exercise at an intensity above the ventilatory threshold|OTHER: Sprint interval training|OTHER: Reduced-exertion high-intensity interval training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Secondary Prevention of Atrial Fibrilation
Status: TERMINATED
Conditions: Atrial Fibrillation|Risk Factors|Risk Reduction Behavior
Interventions: OTHER: AliveCor mobile ECG cardiac monitor|BEHAVIORAL: AF Program|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: a Clinical Research of CD19 and CD22 Targeted Prime CAR-T Cell in Relapsed/Refractory B Cell Lymphoma
Status: RECRUITING
Conditions: B Cell Lymphoma
Interventions: BIOLOGICAL: CD19 and CD22 targeted prime CAR- T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Alogliptin Compared to Glipizide in Elderly Diabetics
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Alogliptin|DRUG: Glipizide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 3-Tesla MRI in Finding Tumors in Patients With Known or Suspected Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: PROCEDURE: 3-Tesla magnetic resonance imaging (3T MRI)|PROCEDURE: diffusion-weighted magnetic resonance imaging|PROCEDURE: dynamic contrast-enhanced magnetic resonance imaging|PROCEDURE: magnetic resonance spectroscopic imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the XEN Implant in Moderate Primary Open Angle Glaucoma (POAG) Participants
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma
Interventions: DEVICE: XEN® Gel Stent|PROCEDURE: Cataract Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine Versus Placebo in COVID-19 Patients at Risk for Severe Disease
Status: TERMINATED
Conditions: Coronavirus
Interventions: DRUG: Hydroxychloroquine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Technique And Results In Endothelial Keratoplasty
Status: COMPLETED
Conditions: Corneal Endothelial Cell Loss|Fuchs' Endothelial Dystrophy
Interventions: PROCEDURE: Descemet Stripping Automated Endothelial Keratoplasty|PROCEDURE: Descemet Membrane Endothelial Keratoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temozolomide and SCH66336 for Recurrent Glioblastoma Multiforme
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Temozolomide and SCH66336
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Toxicity and Efficacy Evaluation of Topical Minoxidil in Acne Vulgaris
Status: RECRUITING
Conditions: Acne Vulgaris
Interventions: DRUG: topical minoxidil in Acne Vulgaris
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Signatures in Inflammatory Skin Disease
Status: RECRUITING
Conditions: Atopic Dermatitis|Psoriasis
Interventions: DRUG: Ustekinumab|DRUG: Infliximab|DRUG: Secukinumab|DRUG: Dupilumab|DRUG: Brodalumab|DRUG: Ixekizumab|DRUG: Baricitinib|DRUG: Abrocitinib|DRUG: Upadacitinib|DRUG: Tralokinumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prospective Influence of Bedtime Insulin Glargine on Mobilization and Function of Endothelial Progenitor Cells
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: Insulin Glargin|DRUG: Human Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Ginger on Menopausal Symptoms
Status: COMPLETED
Conditions: Menopause
Interventions: DIETARY_SUPPLEMENT: Zingiber Officinale powder|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 68Ga-FAPI PET/CT in the Staging of High-Grade Epithelial Ovarian Cancers: A Pilot Study
Status: NOT_YET_RECRUITING
Conditions: High Grade Serous Ovarian Cancer (HGSOC)
Interventions: RADIATION: FAPI PET CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Immunogenicity and Safety of a Multi-Dose Quadrivalent Influenza Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Multi-dose Quadrivalent Influenza Vaccine|BIOLOGICAL: Single-dose Quadrivalent Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Eszopiclone Compared to Placebo in the Treatment of Insomnia Secondary to Perimenopause/Menopause
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: Eszopiclone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunohistochemical Expression of Excision Repair Cross Complementation Group 1 (ERCC1) in Laryngeal Squamous Cell Carcinoma and Its Correlation With Response to Radiotherapy.
Status: NOT_YET_RECRUITING
Conditions: Laryngeal Squamous Cell Carcinoma
Interventions: OTHER: Immunohistochemistry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Low-fat Diet on the Pharmacokinetics of Pyrotinib in Healthy Participants
Status: UNKNOWN
Conditions: Healthy Participants
Interventions: DRUG: pyrotinib maleate fasted in P1, low-fat diet in P2|DRUG: pyrotinib maleate low-fat diet in P1, fasted in P2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mindfulness-Associated Brain Changes in Adults With Autism
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Mindfulness Based Stress Reduction|BEHAVIORAL: Relaxation Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Low-intensity Extracorporeal Shockwave Therapy and Low-intensity Laser Effects in Adhesive Capsulitis
Status: COMPLETED
Conditions: Adhesive Capsulitis
Interventions: OTHER: Low-intensity ESWT Group|OTHER: Low-intensity laser Group|OTHER: Conventional Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ABSOLUTELY: A Temporary Uterine Blood Supply Occlusion for Laparoscopic Myomectomy in Patients With UTErine LeiomYoma
Status: UNKNOWN
Conditions: Uterine Leiomyoma|Uterine Fibroid|Leiomyoma, Uterine|Myoma;Uterus|Laparoscopic Myomectomy|Postoperative Complications|Blood Loss, Surgical|Fertility Issues|Pregnancy Complications
Interventions: PROCEDURE: Laparoscopic myomectomy with prior temporary uterine blood supply occlusion|PROCEDURE: Conventional laparoscopic myomectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atorvastatin in Preventing Nasopharyngeal Carcinoma Patients Receiving Radiotherapy From Carotid Stenosis
Status: SUSPENDED
Conditions: Nasopharyngeal Carcinoma|Radiation Therapy Complication
Interventions: DRUG: Atorvastatin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION