pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Continuation of Oral ONC201 in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor
Interventions: DRUG: Oral ONC201|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opium Tincture Against Chronic Diarrhea - Patients
Status: COMPLETED
Conditions: Chronic Diarrhea
Interventions: DRUG: Opium tincture|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Neoadjuvant Chemotherapy in Terms of DFS in Patients With Localized Digestive Neuroendocrine Carcinomas
Status: RECRUITING
Conditions: Neuroendocrine Carcinoma|Digestive Cancer
Interventions: DRUG: Neoadjuvant treatment|DRUG: Adjuvant treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Development of a Metabolomic Test to Diagnose and Quantify Pancreatic Exocrine Insufficiency (The DETECTION Study)
Status: RECRUITING
Conditions: Pancreatic Exocrine Insufficiency
Interventions: DIAGNOSTIC_TEST: Metabolomics|DIAGNOSTIC_TEST: 13C MTGT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mesenchymal Stem Cells for Lumbar Degenerative Disc Disease
Status: WITHDRAWN
Conditions: Disc Degeneration
Interventions: DRUG: MSC Treatment group 1 (low dose)|DRUG: MSC Treatment group 2 (high dose)|OTHER: Healthy Control (no treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validity and Reliability of Outcome Measures in Patients With Cancer of the Head and Neck
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: OTHER: Six-Minute Walk Test|OTHER: 10-Meter Walk Test|OTHER: 30-Second Chair Stand|OTHER: Linear Analog Scale of Function|OTHER: Modified Brief Fatigue Inventory|OTHER: FACIT-Fatigue
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of CAR-GPRC5D in Patients With Relapsed/Refractory Multiple Myeloma or Plasma Cell Leukemia
Status: UNKNOWN
Conditions: Relapsed/Refractory Multiple Myeloma|Plasma Cell Leukemia
Interventions: DRUG: CAR-T (CAR-GPRC5D)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Efficacy and Safety of REGEND001 Cell Therapy on Idiopathic Pulmonary Fibrosis (IPF)
Status: RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: BIOLOGICAL: REGEND001|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Pharmacodynamics of a New Formulation of Nasal Naloxone for Prehospital Use
Status: COMPLETED
Conditions: Drug Overdose
Interventions: DRUG: Intranasal naloxone|DRUG: Intramuscular naloxone|DRUG: Remifentanil|DEVICE: Aptar Unidose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMSI in Couples With Previous Implantation Failures
Status: TERMINATED
Conditions: Male Infertility|Female Infertility
Interventions: OTHER: Intracytoplasmic morphologically selected sperm injection|OTHER: Intracytoplasmic sperm injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation Effect on Amyotrophic Lateral Sclerosis Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: BIOLOGICAL: Fecal microbiota transplantation|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Wound Infections Following Implant Removal
Status: COMPLETED
Conditions: Surgical Wound Infection
Interventions: DRUG: Cephalozin|OTHER: Sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Adefovir Dipivoxil in Children and Adolescents With Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: Placebo (PLB)|DRUG: Adefovir Dipivoxil (ADV)|DRUG: Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Copanlisib and Avelumab as a Maintenance Therapy for Advanced Bladder Cancer
Status: NOT_YET_RECRUITING
Conditions: Advanced Urothelial Carcinoma
Interventions: DRUG: copanlisib|DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Ranibizumab in Exudative Age-related Macular Degeneration With Posterior Vitreomacular Adhesion
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: PROCEDURE: Intravitreal expansile gas and ranibizumab injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Playground Training to Improve Children's Health After-school and During Recess: The PLAYground Project
Status: COMPLETED
Conditions: Physical Inactivity|Social Skills|Behavior, Child
Interventions: BEHAVIORAL: PlayOn! playground curriculum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Utilizing Imaging Techniques and Evaluating the Safety and Efficacy of SM04690 for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis
Status: TERMINATED
Conditions: Knee Osteoarthritis
Interventions: DRUG: SM04690
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on the Safety and Efficacy of Novel Oncolytic Virus in the Treatment of Recurrent Malignant Glioma
Status: COMPLETED
Conditions: Glioblastoma Multiforme|Gliomas, Malignant
Interventions: BIOLOGICAL: ON-01|DRUG: ONF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Daratumumab, Bortezomib, and Dexamethasone With or Without Venetoclax in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: WITHDRAWN
Conditions: Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: DRUG: Bortezomib|BIOLOGICAL: Daratumumab|DRUG: Dexamethasone|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Batoclimab in Participants With Active Thyroid Eye Disease
Status: RECRUITING
Conditions: Thyroid Eye Disease
Interventions: DRUG: Batoclimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 28-Day Study of SAGE-718 on Functioning Capacity in Participants With Huntington's Disease
Status: COMPLETED
Conditions: Huntington Disease
Interventions: DRUG: SAGE-718|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: QLB vs mTLIP for Lumbar Spinal Surgery
Status: COMPLETED
Conditions: Lumbar Disc Herniation
Interventions: OTHER: Quadratus Lumborum Block|OTHER: Modified-thoracolumbar interfascial plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Endocardial Septal Radiofrequency Ablation in Obstructive Hypertrophic Cardiomyopathy
Status: RECRUITING
Conditions: Obstructive Hypertrophic Cardiomyopathy
Interventions: PROCEDURE: Percutaneous Endocardial Septal Radiofrequency Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Omega-3 Food Supplements in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: PronovaPure 150:500 triglycerides|DIETARY_SUPPLEMENT: Pronovum PRF-048|DIETARY_SUPPLEMENT: Pronovum PRF-037|DIETARY_SUPPLEMENT: PronovaPure 500:200 TG|DIETARY_SUPPLEMENT: Pronovum PRF-047
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Study Evaluating the 24-Hour Pulmonary Function Profile of Fluticasone Furoate (FF) /GW642444 (Vilanterol) (VI) Inhalation Powder 100/25mcg Once Daily Compared With Fluticasone Propionate/Salmeterol Inhalation Powder 250/50mcg Twice Daily in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Fluticasone Furoate 100mcg/ GW642444 (vilanterol) 25mcg|DRUG: Fluticasone Propionate 250mcg / salmeterol 50mcg|DRUG: Double-dummy placebo|DRUG: Salbutamol as needed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pedicle Screw Usage in Conventional Fixation Pattern Constructs Compared to Thoracic Hook Constructs in Scoliosis
Status: COMPLETED
Conditions: Adolescent Idiopathic Scoliosis
Interventions: DEVICE: Pedicle screws|DEVICE: Laminar Hooks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Novel Neurofeedback Protocol on ADHD Subcomponents
Status: ACTIVE_NOT_RECRUITING
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: OTHER: NEUROFEEDBACK|OTHER: CONTROL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Akkermansia Muciniphilia and Metabolic Side Effects of ADT
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer|Metabolic Syndrome|Obesity|Cardiovascular Morbidity|Bone Diseases|Hyperlipidemias|Diabetes
Interventions: DRUG: Apple Cider Vinegar|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cost-effectiveness of Adalimumab and Surgery vs Adalimumab in HS
Status: UNKNOWN
Conditions: Hidradenitis Suppurativa
Interventions: PROCEDURE: Wide Excision|DRUG: Adalimumab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tirzepatide: Reversal of Lipotoxicity and Adipose Tissue Dysfunction in Humans With Overweight/Obesity
Status: NOT_YET_RECRUITING
Conditions: Obesity|Overweight and Obesity|Overweight
Interventions: DRUG: Tirzepatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Netarsudil (AR-13324) Ophthalmic Solution in Patients With Glaucoma and Ocular Hypertension
Status: COMPLETED
Conditions: Ocular Hypertension|Open-angle Glaucoma
Interventions: DRUG: AR-13324 Ophthalmic Solution 0.02%|DRUG: Timolol maleate Ophthalmic Solution 0.5% BID|OTHER: Placebo|DRUG: AR-13324 Ophthalmic Solution 0.02% BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BrUOG 292: FOLFOX-A For Metastatic Pancreatic Cancer: A Phase II Brown University Oncology Research Group Trial
Status: COMPLETED
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: FOLFOXA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide Versus Placebo in Myelodysplastic Syndromes With a Deletion 5q[31] Abnormality
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Lenalidomide 5 mg|DRUG: Lenalidomide 10 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Sedation/Cognition/Electroencephalogram (EEG) Study Using AZD7325 and Comparator.
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: AZD7325|DRUG: AZD7325|DRUG: AZD7325|DRUG: Lorazepam|DRUG: Lorazepam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Muticenter Clinical Study of Chinese Herbal Compound TJAOA102 in Alleviating Menopausal Syndrome
Status: NOT_YET_RECRUITING
Conditions: Menopausal Syndrome
Interventions: DRUG: TJAOA102
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Non Inferiority Bi-Profenid® 200mg Versus Bi-Profenid® 300mg Among Patients Presenting of the Post-traumatic or Rheumatologic Acute Affections of the Locomotor Apparatus (BIPROPAIN)
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: ketoprofen 100 mg|DRUG: ketoprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Maintenance Chemotherapy for Metastatic Colorectal Carcinoma and Biological Marker
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Capecitabine|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of a Patient-Specific Neoantigen Vaccine in Combination With Immune Checkpoint Blockade for Patients With Metastatic Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Neoplasms
Interventions: DRUG: GRT-C901|DRUG: GRT-R902|DRUG: Atezolizumab|DRUG: Ipilimumab|DRUG: Fluoropyrimidine plus leucovorin|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Foot Exercises and Anti-pronation Taping on Low Back Pain Associated With Hyper Pronation
Status: NOT_YET_RECRUITING
Conditions: Low Back Pain
Interventions: OTHER: Anti-pronation taping (Low dye taping) + Conventional therapy|OTHER: Short Foot Exercises + Conventional PT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of Baby Carrying Methods on Females Balance During Standing
Status: COMPLETED
Conditions: Balance; Distorted
Interventions: DEVICE: Baby carrier|DEVICE: Biodex Balance System|OTHER: Infant mannequin|DEVICE: Biodex gait trainer 2 TM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bipolar Transurethral Enucleation (BipolEP) vs Bipolar Transurethral Resection of the Prostate
Status: UNKNOWN
Conditions: Benign Prostatic Hyperplasia|Bladder Outlet Obstruction
Interventions: PROCEDURE: BipolEP|PROCEDURE: bipolarTURP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thromboelastography As An Assessment Tool for Possible Clopidogrel and Aspirin Resistance
Status: UNKNOWN
Conditions: Acute ST SEgment Elevation Myocardial Infarction
Interventions: DRUG: Aspirin (200mg) and/or Plavix (150mg) dosage according to TEG|DRUG: Aspirin 100mg and Plavix 75mg
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Validation of Dental Malocclusion Schematic Representations for Early Orthodontic Treatment
Status: COMPLETED
Conditions: Dental Malocclusion
Interventions: OTHER: Dental Exam|OTHER: Orthodontics consult|OTHER: Call back at 6 month
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intraoperative Radiation Therapy (IORT) in DCIS
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Ductal Carcinoma in Situ
Interventions: OTHER: Quality of Life Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Nutritional Products on Metabolic Parameters in Subjects With Type 2 Diabetics
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: No breakfast/beverage only|OTHER: Breakfast|OTHER: 10004RF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin K to Slow Progression of Cardiovascular Disease Risk in Hemodialysis Patients
Status: UNKNOWN
Conditions: Cardiovascular Diseases|Chronic Kidney Disease Stage 3|Chronic Kidney Disease Stage 4|Chronic Kidney Disease Stage 5|Vitamin K Deficiency|Hemodialysis
Interventions: DIETARY_SUPPLEMENT: Vitamin K2 (menaquinone-7; 360-mcg/d)|DIETARY_SUPPLEMENT: Placebo-Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Performance and Safety of the Atoldys/ Lexilens Glasses Developed to Improve the Reading of Dyslexic Subjects
Status: COMPLETED
Conditions: Dyslexia
Interventions: DEVICE: Atoldys/ Lexilens - SHAM|DEVICE: SHAM- Atoldys/ Lexilens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Number One Overall Graft Pick? Hamstring vs Bone-Patellar-Tendon-Bone vs Quadriceps Tendon
Status: ACTIVE_NOT_RECRUITING
Conditions: Anterior Cruciate Ligament Rupture
Interventions: PROCEDURE: ACL reconstruction - graft choice
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Aldesleukin in Treating Patients With Metastatic Clear Cell Carcinoma of the Kidney
Status: COMPLETED
Conditions: Kidney Cancer
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Nested Case-control Study on the Secondary Prevention of Ischemic Stroke and TIA by Hypertension Health Education Protocol (HHEP): The Post-Stroke Preventive Trial
Status: UNKNOWN
Conditions: To Investigate the Relationship Between the Adherence of HHEP After ISTIA and Stroke Recurrence or Cardiovascular Events.
Interventions: OTHER: Hypertension Health Education Protocol (HHEP)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate EDP 938 Regimens in Children With RSV
Status: RECRUITING
Conditions: Respiratory Syncytial Virus (RSV)
Interventions: DRUG: EDP-938|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of LP002 in Combination With Chemotherapy for Patients With Extensive Stage Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Small-cell Lung Cancer
Interventions: DRUG: LP002|DRUG: Carboplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Itacitinib for the Prevention of Graft Versus Host Disease in Patients Undergoing Donor Stem Cell Transplantation
Status: WITHDRAWN
Conditions: Allogeneic Stem Cell Transplant Recipient|Hematologic and Lymphocytic Disorder|Hematopoietic and Lymphoid Cell Neoplasm
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Busulfan|DRUG: Fludarabine|DRUG: Itacitinib|DRUG: Methotrexate|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia (ALL)
Interventions: DRUG: Carfilzomib|DRUG: Dexamethasone|DRUG: Mitoxantrone|DRUG: PEG-asparaginase|DRUG: Vincristine|DRUG: Intrathecal (IT) Methotrexate|DRUG: Intrathecal Triple Therapy (Intrathecal Cytarabine, Hydrocortisone, and Methotrexate)|DRUG: 6-Mercaptopurine|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Daunorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D3 in Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus|SLE|Lupus
Interventions: DRUG: Vitamin D3|DRUG: Vitamin D3 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral N-acetylcysteine for Protection of Human Nevi Against UV-induced Oxidative Stress/Damage in Vivo
Status: COMPLETED
Conditions: Patients at Risk for Melanoma
Interventions: DRUG: N-acetylcysteine|OTHER: Placebo arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Test Whether BI 685509 Alone or in Combination With Empagliflozin Helps People With Liver Cirrhosis Caused by Viral Hepatitis or Non-alcoholic Steatohepatitis (NASH) Who Have High Blood Pressure in the Portal Vein (Main Vessel Going to the Liver)
Status: TERMINATED
Conditions: Liver Diseases|Hypertension, Portal
Interventions: DRUG: Avenciguat (BI 685509)|DRUG: Empagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beetroot Juice and Sleep
Status: RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Active Beetroot Juice Supplement (aBRJ)|DIETARY_SUPPLEMENT: Placebo Beetroot Juice Supplement (pBRJ)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy on Volume Reduction and Tolerance of Progressiv' Medical Compressive Therapy (MCT) V0322 BC in Patients With Chronic Venous Oedema
Status: COMPLETED
Conditions: Chronic Venous Insufficiency (CVI)
Interventions: DEVICE: V0322 BC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2, Randomized, Placebo Controlled Study Investigating the Efficacy and Safety of Sorafenib in New-Onset Type 1 Diabetes Mellitus
Status: NOT_YET_RECRUITING
Conditions: Type 1 Diabetes
Interventions: DRUG: Sorafenib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy, and Tolerability Study of PF-06480605 in Subjects With Moderate to Severe Ulcerative Colitis.
Status: COMPLETED
Conditions: Colitis, Ulcerative
Interventions: DRUG: PF-06480605
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Tolerance and Pharmacokinetic Profile of High Doses of Favipiravir in Healthy Volunteers
Status: RECRUITING
Conditions: Infectious Disease|Pharmacology
Interventions: DRUG: favipiravir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin K Supplementation to Reduce Deficiencies in Adults With Cystic Fibrosis
Status: WITHDRAWN
Conditions: Cystic Fibrosis
Interventions: DIETARY_SUPPLEMENT: Vitamin K supplementation, dose #1|DIETARY_SUPPLEMENT: Vitamin K supplementation, dose #2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nab-paclitaxel Combined With Gemcitabine as Adjuvant Therapy for Pancreatic Cancer After Curative Resection
Status: COMPLETED
Conditions: Stage IA Pancreatic Adenocarcinoma|Stage IB Pancreatic Adenocarcinoma|Stage IIA Pancreatic Adenocarcinoma|Stage IIB Pancreatic Adenocarcinoma
Interventions: DRUG: nab-paclitaxel|DRUG: gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stellate Ganglion Block for COVID-19-Induced Olfactory Dysfunction
Status: COMPLETED
Conditions: Anosmia|Hyposmia|Parosmia|Olfactory Disorder
Interventions: DRUG: Stellate Ganglion Block
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adequate Hydration Therapy Combined With Intravenous Infusion of Isosorbide Dinitrate Prevention for CIN
Status: UNKNOWN
Conditions: Cardio-Renal Syndrome
Interventions: PROCEDURE: Hydration Combined With Intravenous Infusion of Isosorbide Dinitrate|DRUG: Visipaque|DRUG: 0.9% sodium chloride ﬂuid administration|DRUG: isosorbide dinitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of TP10, a Complement Inhibitor, in Adult Women Undergoing Cardiopulmonary Bypass Surgery
Status: COMPLETED
Conditions: Myocardial Ischemia|Coronary Arteriosclerosis|Aortic Valve Insufficiency|Mitral Valve Insufficiency
Interventions: DRUG: TP10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: High/Low Dose Vit A in Diarrhea/ALRI in Severe PEM
Status: COMPLETED
Conditions: Respiratory Infections|Diarrhea|Malnutrition
Interventions: DRUG: Vitamin A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Fracture Fixation With Energy and Cement in Tumors of the Spine
Status: WITHDRAWN
Conditions: Spinal Fractures
Interventions: DEVICE: SPACE CpsXL Bone Cement and SPACE 360 Delivery System|DEVICE: standard vertebroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Analgesia After Total Hip Replacement
Status: COMPLETED
Conditions: Total Hip Replacement
Interventions: DRUG: Intrathecal morphine at surgery, 0.1mg and placebo|DRUG: Patient Controlled Analgesia with iv morphine and placebo|DRUG: intrathecal morphine AND patient controlled analgesia with iv morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Combined Effect of Intravesical Botox Injections and HoLEP Surgery in Treating Benign Prostatic Hyperplasia and Overactive Bladder
Status: NOT_YET_RECRUITING
Conditions: Benign Prostatic Hyperplasia|Overactive Bladder
Interventions: DRUG: Intravesical Botox injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Non-invasive Vagus Nerve Stimulation (t-VNS) in the Treatment of Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DEVICE: t-VNS verum|DEVICE: t-VNS placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clevidipine for Vasospasm After Subarachnoid Hemorrhage (SAH)
Status: WITHDRAWN
Conditions: Subarachnoid Hemorrhage|Cerebral Aneurysm|Vasospasm, Intracranial
Interventions: DRUG: clevidipine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Xenazine in Late Dyskinetic Syndrome With Neuroleptics
Status: COMPLETED
Conditions: Tardive Dyskinesia
Interventions: DRUG: Tetrabenazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gastric Variceal Ligation Versus Gastric Variceal Obturation for Secondary Prophylaxis of Gastric Varices
Status: UNKNOWN
Conditions: Gastroesophageal Varices|Liver Cirrhosis
Interventions: PROCEDURE: gastric variceal ligation|PROCEDURE: gastric variceal obturation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Aerobic Exercise in Patients With Pulmonary Hypertension
Status: COMPLETED
Conditions: Pulmonary Hypertension|Interstitial Lung Disease
Interventions: OTHER: Aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Gebasaxturev (V937) in Combination With Pembrolizumab (MK-3475) in Participants With Advanced/Metastatic Solid Tumors (V937-013)
Status: TERMINATED
Conditions: Neoplasm Metastasis
Interventions: BIOLOGICAL: Gebasaxturev|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OnabotulinumtoxinA for the Treatment of Urinary Incontinence Due to Overactive Bladder in Pediatric Patients (12 to 17)
Status: TERMINATED
Conditions: Urinary Incontinence|Urinary Bladder|Overactive
Interventions: BIOLOGICAL: BOTOX®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of SPD489 in Adolescent Subjects Aged 13-17 Years With Attention-Deficit/Hyperactivity Disorder (ADHD)
Status: WITHDRAWN
Conditions: ADHD
Interventions: DRUG: SPD489|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Nebulized Dexmedetomidine in Blunting the Effects of Direct Laryngoscopy and Endotracheal Tube on Heart Rate and Blood Pressure.
Status: RECRUITING
Conditions: Hemodynamic Instability
Interventions: DRUG: Dexmedetomidine Injection [Precedex]|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Safety of Totally Laparoscopic Versus Laparoscopy-Assisted Total Gastrectomy.
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: PROCEDURE: Totally Laparoscopic Total Gastrectomy|PROCEDURE: Laparoscopy-Assisted Total Gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Ondansetron Dose and Timing on Post-operative Nausea and Vomiting
Status: COMPLETED
Conditions: Post-operative Nausea and Vomiting
Interventions: DRUG: Ondansetron 4 MG|DRUG: Ondansetron 8mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating Glucose Control Using a Next Generation Automated Insulin Delivery Algorithm in Patients With Type 1 and Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: Omnipod 5 Automated Glucose Control System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Discontinuation of Antipsychotics and Antidepressants Among Patients With BPSD
Status: COMPLETED
Conditions: Dementia
Interventions: DRUG: Risperidone|DRUG: Olanzapine|DRUG: Haloperidole|DRUG: Quetiapin|DRUG: Escitalopram|DRUG: Citalopram|DRUG: Sertralin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home-Based Physical Activity Intervention for Taxane-Induced CIPN
Status: RECRUITING
Conditions: Breast Cancer Female|Chemotherapy-induced Peripheral Neuropathy|Gait Disorders, Neurologic|Balance; Distorted|Muscle Weakness
Interventions: BEHAVIORAL: Gait/balance & resistive exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Feasibility of TA-CIN Vaccine in HPV16 Associated Cervical Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: HPV16 Associated Cervical Cancer
Interventions: BIOLOGICAL: TA-CIN (arm)|BIOLOGICAL: TA-CIN (thigh)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Learn How Much Rivaroxaban Gets Into the Blood When Taken in Different Forms and How Safe They Are in Healthy Men
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: 20 mg tablet rivaroxaban|DRUG: 20 mg rivaroxaban, granules for oral suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Course Radiotherapy for the Treatment of Patients With Glioblastoma, SAGA Study
Status: RECRUITING
Conditions: Glioblastoma
Interventions: RADIATION: Accelerated Hypofractionated Radiation Therapy|PROCEDURE: Computed Tomography|DRUG: Fluorodopa F 18|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|RADIATION: Radiation Therapy|DRUG: Temozolomide|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy of Erbium:YAG 2940nm in Combination With 1064nm Laser on Facial Rejuvenation
Status: COMPLETED
Conditions: Facial Rejuvenation
Interventions: RADIATION: Fotona 4D 1064 nm laser|RADIATION: Fotona 4D 2940 nm laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Fekry and Air-Q Intubating Airways as Conduit for Fibreoptic Endotracheal Intubation in Adult Patients
Status: COMPLETED
Conditions: Fekry VS the Air-Q Intubating Airways
Interventions: DEVICE: Patients will be intubated using Air-Q airway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of ONO-8539 in Patients With Overactive Bladder
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: Placebo|DRUG: Tolterodine|DRUG: ONO-8539|DRUG: ONO-8539|DRUG: ONO-8539
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Intervention on Metabolic Homeostasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Homeostasis|Metabolism and Nutrition Disorder|Healthy|Obesity
Interventions: BEHAVIORAL: General lifestyle and nutritional education|BEHAVIORAL: Personalized nutritional and lifestyle weight reduction intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Enzastaurin Before and Concomitant With Radiation, Followed by Enzastaurin in Participants With Newly Diagnosed Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Enzastaurin 500 milligram (mg) Once Daily (QD)|DRUG: Enzastaurin 250 mg Twice Daily (BID)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of an Oral Contraceptive
Status: COMPLETED
Conditions: Prevention of Pregnancy
Interventions: DRUG: Norethindrone Acetate/Ethinyl Estradiol 24 Days|DRUG: Norethindrone Acetate /Ethinyl Estradiol 21 Days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dual Anti-glutamate Therapy in Super-refractory Status Epilepticus After Cardiac Arrest
Status: RECRUITING
Conditions: Status Epilepticus|Cardiac Arrest
Interventions: DRUG: Ketamine|DRUG: Any anti-epileptic and anesthetic therapy, excluding Ketamine and Perampanel
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Left Bundle Branch Area Pacing vs. Right Ventricular Pacing in Atrioventricular Block (LEAP-Block)
Status: RECRUITING
Conditions: Atrioventricular Block|Left Bundle Branch Area Pacing|Right Ventricular Pacing|Heart Failure
Interventions: DEVICE: Left bundle branch area pacing|DEVICE: Right ventricular pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: G3P-01 in Volunteers With Elevated Galectin-3
Status: COMPLETED
Conditions: Galectin 3|Healthy Aging
Interventions: DIETARY_SUPPLEMENT: G3P-01|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Stendo Pulsating Suit on Microcirculation and Central Blood Pressure in Essential Hypertension Patients
Status: UNKNOWN
Conditions: Essential Hypertension
Interventions: DEVICE: Stendo pulsating suit System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non Celiac Gluten Sensitivity, DBPCFC in Adolescents
Status: UNKNOWN
Conditions: Non-celiac Gluten Sensitivity; Adolescents
Interventions: DIAGNOSTIC_TEST: positive test followed by gluten-free diet|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Analgesic Efficacy of Transmucosal Fentanyl for Breakthrough Pain Caused by Interventional Gastrostomy
Status: COMPLETED
Conditions: Gastrostomy|Breakthrough Pain|Upper Aerodigestive Tract Neoplasms
Interventions: DRUG: Fentanyl|DRUG: Morphine Sulfate|DRUG: Fentanyl placebo|DRUG: Morphine Sulfate placebo|PROCEDURE: Gastrostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Seronegatives and Metabolic Abnormalities Protocol 2 (SAMA002): Study to Compare the Effect of Kaletra and Combivir® in HIV-Negative Healthy Subjects
Status: COMPLETED
Conditions: HIV Infections|Dyslipidemias|Glucose Metabolism Disorders|Metabolic Diseases|Lipodystrophy|Cardiovascular Disease
Interventions: DRUG: Combivir (zidovudine [AZT] / lamivudine [3TC])|DRUG: Kaletra (lopinavir [LPVr])
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study With BioCool Footcare in Subjects With Tinea Pedis Interdigitalis and Heel Cracks, Calluses and/or Dry Feet
Status: COMPLETED
Conditions: Foot Fungus|Tinea|Tinea Pedis|Mycoses|Skin Diseases
Interventions: DEVICE: Biocool Footcare
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving the Mental Health of Home Health Aides
Status: NOT_YET_RECRUITING
Conditions: Mental Health Issue
Interventions: BEHAVIORAL: Living Healthy educational program + peer coaching|BEHAVIORAL: Living Healthy educational program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Association Between Anaemia and Handgrip Strength in Female Planned for Major Surgery and the Effect of Intravenous Iron on Handgrip Strength
Status: UNKNOWN
Conditions: Anemia|Iron-deficiency|Patient Blood Management|Iron Deficiency Anemia
Interventions: DEVICE: Jamar hydraulic hand dynamometer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Investigating Whether Low Dose Eyedrops for Pupil Dilation is as Effective and Safe as Standard Dose Eyedrops in Examination for Retinopathy of Prematurity.
Status: COMPLETED
Conditions: Retinopathy of Prematurity
Interventions: DRUG: Microdrop Mydrin-P|DRUG: Standard Mydrin-P
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Spiriva® 18 Microgram on Health-related Quality of Life and Physical Functioning in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Proven Hyperinflation
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium bromide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessing the Safety and Tolerability of a Single IV Dose of AZD9742 in Healthy Elderly Male and Female Subjects
Status: COMPLETED
Conditions: Tolerability|Healthy|Elderly
Interventions: DRUG: AZD9742|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of a Quadrivalent Human Papillomavirus (HPV) Vaccine in Patients With SLE: a Controlled Study
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: human papillomavirus vaccination (Gardasil)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Duvelisib for Ibrutinib-Resistant Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Status: TERMINATED
Conditions: Small Lymphocytic Leukemia (SLL)|Chronic Lymphocytic Leukemia (CLL)
Interventions: DRUG: Duvelisib|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid Disorders
Status: RECRUITING
Conditions: Cushing Syndrome|Adrenal Insufficiency|Cushing Disease|Addison Disease
Interventions: DIAGNOSTIC_TEST: circadian gene expression evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Study to Investigate the Sleep Quality Enhancing Effect of GABA
Status: COMPLETED
Conditions: Sleep Disturbance
Interventions: DIETARY_SUPPLEMENT: GABA|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Caudal Nalbuphine on Postoperative Emergence Agitation in Pediatrics Undergoing Infra-umbilical Surgeries
Status: UNKNOWN
Conditions: Agitation, Emergence|Post Operative Pain
Interventions: DRUG: Nalbuphine|DRUG: Bupivacain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Relation Between Human Epididymis Protein 4 (HE4) and Endometrial Pathology in Patients With Postmenopausal Bleeding
Status: COMPLETED
Conditions: Postmenopausal Bleeding
Interventions: PROCEDURE: Hysteroscopic guided fractional curretage|PROCEDURE: total abdominal hysterectomy, bilateral salpingo oophrectomy, with or without pelvic lymph nodal dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Selective Internal Radiation Therapy (SIRT) Using SIR-Spheres® Y-90 Resin Microspheres on DoR & ORR in Unresectable Hepatocellular Carcinoma Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Unresectable Hepatocellular Carcinoma|BCLC Stage A Hepatocellular Carcinoma|BCLC Stage B Hepatocellular Carcinoma|BCLC Stage C Hepatocellular Carcinoma
Interventions: DEVICE: Resin microspheres containing yttrium-90 (Y-90)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT