pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of Zolbetuximab (IMAB362) Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-Positive, HER2-Negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer|Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer|Metastatic Gastric Adenocarcinoma or Cancer|Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma
Interventions: DRUG: zolbetuximab|DRUG: oxaliplatin|DRUG: capecitabine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Evaluation of Low-Dose Oral Etoposide for the Treatment of Relapsed or Progressed AIDS-Related Kaposi's Sarcoma After Systemic Chemotherapy
Status: COMPLETED
Conditions: Sarcoma, Kaposi|HIV Infections
Interventions: DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid Prophylaxis for Heterotopic Ossification in Elbow Fracture-Dislocation Surgery
Status: COMPLETED
Conditions: Elbow Dislocation|Heterotopic Ossification
Interventions: DRUG: with Tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial to Evaluate CT053 in Patients With Relapsed and/or Refractory Multiple Myeloma (LUMMICAR STUDY 1)
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: CAR-BCMA T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Usefulness & Usability of a Healthcare IT System for Managing Multi-morbidity and Poly-pharmacy
Status: UNKNOWN
Conditions: Diabetes Type 2|Renal Failure|Heart Failure|Depression|Chronic Disease|Aging
Interventions: DEVICE: Use of the C3-Cloud IT system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Toronto and Oak Ridge Photobiomodulation Study for Dry Age Related Macular Degeneration
Status: COMPLETED
Conditions: Nonexudative Age-related Macular Degeneration
Interventions: DEVICE: Photobiomodulation (Gentlewaves, Warp 10)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Miniscrew Anchored Maxillary Protraction Protocols
Status: COMPLETED
Conditions: Malocclusion, Angle Class III|Crossbite (Anterior) (Posterior)
Interventions: DEVICE: MAMP therapy with MARPE expander|DEVICE: MAMP therapy with Hyrax expander
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reverse Total Shoulder Arthroplasty: A Data Analysis on Patients Undergoing Reverse Total Shoulder Arthroplasty
Status: UNKNOWN
Conditions: Osteo Arthritis Shoulders|Proximal Humeral Fracture|Rotator Cuff Tear|Rotator Cuff Tear Arthropathy
Interventions: OTHER: reverse total shoulder arthroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Gene Therapy for APOE4 Homozygote of Alzheimer's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer Disease|Early Onset Alzheimer Disease
Interventions: BIOLOGICAL: LX1001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selenium Supplementation in Youths With Autoimmune Thyroiditis
Status: COMPLETED
Conditions: Autoimmune Thyroiditis
Interventions: DIETARY_SUPPLEMENT: L-selenomethionine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Steroids on Intra-dialytic Hypotension
Status: COMPLETED
Conditions: Dialysis Hypotension
Interventions: DRUG: Hydrocortisone|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Monitoring of Lung Ventilation Through Electrical Impedance Tomography During Pediatric Surgery
Status: NOT_YET_RECRUITING
Conditions: Ventilator Lung|Surgery|Pediatric
Interventions: DEVICE: Electrical impedance tomography assessment of ventilation distribution in course of sedation/general anesthesia for pediatric surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Anemia Studies in Chronic Kidney Disease (CKD): Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat in Non-Dialysis Subjects Evaluating Hemoglobin (Hgb) and Quality of Life (ASCEND-NHQ)
Status: COMPLETED
Conditions: Anaemia
Interventions: DRUG: Daprodustat (GSK1278863)|DRUG: Placebo|DRUG: Iron therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Carotid Atherosclerosis Regression at Magnetic Resonance Assessment.
Status: COMPLETED
Conditions: Established Carotid Atherosclerosis
Interventions: DRUG: Niacin/simvastatin compared to simvastatin alone at 2 doses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of rAAV2/8-hCYP4V2 in Patients With Bietti's Crystalline Dystrophy (BCD)
Status: UNKNOWN
Conditions: Bietti's Crystalline Dystrophy
Interventions: DRUG: rAAV2/8-hCYP4V2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Co-packaging With Zinc to Improve Treatment of Diarrhea and Pneumonia in Guatemala
Status: UNKNOWN
Conditions: Diarrhea.|Pneumonia.
Interventions: BEHAVIORAL: Co-packaging and counseling messages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy of Sorafenib in Renal Cell Carcinoma Patients After a Radical Resection of the Metastases
Status: UNKNOWN
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TKM 080301 for Primary or Secondary Liver Cancer
Status: COMPLETED
Conditions: Colorectal Cancer With Hepatic Metastases|Pancreas Cancer With Hepatic Metastase|Gastric Cancer With Hepatic Metastase|Breast Cancer With Hepatic Metastase|Ovarian Cancer With Hepatic Metastase
Interventions: DRUG: TKM-080301
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Xpede Clinical Study
Status: COMPLETED
Conditions: Pathological Fracture of Vertebra Due to Secondary Osteoporosis (Disorder)|Pathological Fracture of Vertebra Due to Neoplastic Disease (Disorder)
Interventions: DEVICE: Xpede™ Bone Cement|DEVICE: Mendec Spine Bone Cement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Observation and Follow-up in People With Basal Cell Carcinoma
Status: RECRUITING
Conditions: Basal Cell Carcinoma
Interventions: DIAGNOSTIC_TEST: Digital Dermoscopy|DIAGNOSTIC_TEST: Reflectance confocal microscopy (RCM)|DIAGNOSTIC_TEST: Optical coherence tomography (OCT)|DIAGNOSTIC_TEST: Dermtech tape-stripping|DIAGNOSTIC_TEST: Total Skin Examinations
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Light-emitting Diode (LED) Photobiomodulation Therapy on Muscular Fatigue in University Handball Athletes
Status: UNKNOWN
Conditions: Muscular Injury
Interventions: DEVICE: Fotobiomodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Of AL101In Patients With Adenoid Cystic Carcinoma (ACC) Bearing Activating Notch Mutations
Status: COMPLETED
Conditions: Adenoid Cystic Carcinoma
Interventions: DRUG: AL101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compression Only CPR Versus Standard CPR in Out-Of-Hospital Cardiac Arrest - A Randomized Survival Study
Status: RECRUITING
Conditions: Out-Of-Hospital Cardiac Arrest|Cardiac Arrest|Cardiopulmonary Resuscitation
Interventions: OTHER: Chest Compression Only CPR (CO-CPR) performed by trained bystanders after instructions from dispatchers|OTHER: Standard CPR (S-CPR) performed by trained bystanders after instructions from dispatchers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of a Novel Lipid Formulation of Cannabidiol Compared to a Standard Formulation
Status: COMPLETED
Conditions: Absorption; Chemicals
Interventions: DRUG: Standard formulation|DRUG: Novel formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Home-Based Intervention for Chronic Pain in Adults With Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DEVICE: EaseVRx|BEHAVIORAL: Audio-only version of EaseVRx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Compliance to Follow-up in Patients With Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: OTHER: WhatsApp group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-Cell Maturation Antigen (BCMA) in Participants With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: JNJ-68284528
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Fosmidomycin and Piperaquine in the Treatment of Acute Falciparum Malaria
Status: UNKNOWN
Conditions: Oral Treatment of Acute Uncomplicated Plasmodium Falciparum Malaria
Interventions: DRUG: Fosmidomycin-Piperaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Changes and Neural Correlates After Rehabilitation of Masticatory Function in Elderly -an Intervention Study
Status: RECRUITING
Conditions: Chewing Problem|Cognitive Decline|Magnetic Resonance Imaging|Degenerative; Dementia|Mastication Disorder|Neurocognitive Dysfunction
Interventions: PROCEDURE: Oral prosthetic rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weekly Carboplatin, Paclitaxel and Cetuximab Treatment for Patients With Recurrent or Metastatic SCCHN
Status: COMPLETED
Conditions: Head and Neck Cancer|Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Cetuximab|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Cholesterol-lowering L. Plantarum on Cardiometabolic Health Biomarkers in Coeliac Disease Patients
Status: RECRUITING
Conditions: Celiac Disease
Interventions: DIETARY_SUPPLEMENT: LP-LDL Probiotic|DIETARY_SUPPLEMENT: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (Explores What the Body Does to the Drug), and Pharmacodynamics (Explores What a Drug Does to the Body) of JNJ-38431055 in Volunteers With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: JNJ-38431055 Dose 1|DRUG: Sitagliptin 100 mg|DRUG: Placebo|DRUG: JNJ-38431055 Dose 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluating the Efficacy, Safety, and Pharmacokinetics of SNC-102 in Subjects With Tourette Syndrome
Status: WITHDRAWN
Conditions: Tourette Syndrome
Interventions: DRUG: SNC-102 sustained release tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebellar Involvement in Alcohol Use Disorder (AUD)
Status: RECRUITING
Conditions: Alcohol Use Disorder
Interventions: PROCEDURE: cerebellar transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: RGS@Home: Personalized 24/7 Home Care Post-stroke
Status: UNKNOWN
Conditions: Hemiparesis;Poststroke/CVA|Stroke, Acute|Motor Disorders|Spasticity, Muscle
Interventions: DEVICE: RGS based training and monitoring|BEHAVIORAL: Therapy as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Based on Medical Records That Looks at the Duration of Use of Two Types of Inhalers With Different Medicines in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Olodaterol/Tiotropium Bromide|DRUG: Umeclidinium/ Vilanterol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparing Arrow PICC Catheters w/ Arrowga+rd Blue Advanced Protection Performance and Safety to Unprotected PICC's
Status: UNKNOWN
Conditions: Peripherally Inserted Central Catheter
Interventions: DEVICE: Arrowga+rd Blue Advance Protection PICC Placement|DEVICE: Sham Comparator PICC placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Nocturnal Low-dose Dexmedetomidine Infusion and Perioperative Sleep Quality
Status: NOT_YET_RECRUITING
Conditions: Old Age|Knee Replacement Surgery|Hip Replacement Surgery|Dexmedetomidine|Sleep Quality
Interventions: DRUG: Dexmedetomidine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: GSK573719 Dose Ranging Study in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium|DRUG: Placebo|DRUG: GSK573179
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rosuvastatin/Amlodipine vs Atorvastatin/Amlodipine in Hypertension Patient With Dyslipidemia
Status: COMPLETED
Conditions: Dyslipidemias|Hypertension
Interventions: DRUG: Rosuampin 10/5mg|DRUG: Rosuampin 20/5mg|DRUG: Amlodipine/Atorvastatin 5/20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of BAY43-9006 in Patients With Unresectable and/or Metastatic Renal Cell Cancer
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Sorafenib (Nexavar, BAY43-9006)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Recovery and Lifespan of Red Blood Cells From Pathogen-reduced, Stored Blood Units
Status: UNKNOWN
Conditions: Red Cell Survival in Healthy Volunteers
Interventions: DEVICE: Red cell survival in INTERCEPT treated red cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Quantification of Cerebral Blood Flow by Arterial Spin Labeling in Vasospasm in Subarachnoid Haemorrhage
Status: UNKNOWN
Conditions: Subarachnoid Hemorrhage
Interventions: DEVICE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: rAAV-Olig001-ASPA Gene Therapy for Treatment of Children With Typical Canavan Disease
Status: RECRUITING
Conditions: Canavan Disease
Interventions: DRUG: rAAV-Olig001-ASPA|DRUG: Levetiracetam|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Mindfulness Therapy in Orofacial Chronic Pain
Status: UNKNOWN
Conditions: Mindfulness|Chronic Pain|Orofacial Pain
Interventions: OTHER: mindfulness-based stress reduction|OTHER: Minimal intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proteomic Analysis of Mononuclear Cells After a High-Fat, High-Carbohydrate Meal With or Without Orange Juice
Status: COMPLETED
Conditions: Inflammation
Interventions: OTHER: Orange juice|OTHER: Water|OTHER: Water with glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: BRAINFUL (BRAIN Tumor Focused Ultrasound-enabled Liquid Biopsy) Trial
Status: RECRUITING
Conditions: Brain Neoplasms|Liquid Biopsy
Interventions: PROCEDURE: Magnetic Resonance Guided Focused Ultrasound Tumor Ablation and Liquid Biopsy Acquisition|PROCEDURE: Magnetic Resonance Guided Focused Ultrasound Thalamotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Yttrium-90 Labeled Anti-CD25 Monoclonal Antibody Combined With BEAM Chemotherapy Conditioning for the Treatment of Primary Refractory or Relapsed Hodgkin Lymphoma
Status: RECRUITING
Conditions: Recurrent Hodgkin Lymphoma|Refractory Hodgkin Lymphoma
Interventions: BIOLOGICAL: Basiliximab|DRUG: Carmustine|DRUG: Cytarabine|DRUG: Etoposide|BIOLOGICAL: Genetically Engineered Hematopoietic Stem Progenitor Cells|BIOLOGICAL: Recombinant Granulocyte Colony-Stimulating Factor|BIOLOGICAL: Yttrium Y 90 Basiliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RT With or Without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: cetuximab|RADIATION: intensity-modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interferon Alfa Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Stage III or Stage IV Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: recombinant interferon alfa|BIOLOGICAL: sargramostim|DRUG: cyclophosphamide|DRUG: dexamethasone|DRUG: melphalan|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Pacritinib and Chemotherapy in Treating Patients With Acute Myeloid Leukemia and FLT3 Mutations
Status: COMPLETED
Conditions: Recurrent Adult Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Therapy-Related Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: Pacritinib|DRUG: Cytarabine|DRUG: Daunorubicin Hydrochloride|DRUG: Decitabine|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine (Second Sub-Project)
Status: COMPLETED
Conditions: Itch
Interventions: DRUG: Capsaicin|DRUG: Diphenhydramine|DRUG: Morphine Chloride|DRUG: Isotonic saline|DRUG: Histamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Relapsed or Refractory Advanced Non-Small Cell Lung Cancer With an FGFR Alteration
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer (NSCLC)
Interventions: DRUG: Pemigatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Phenylbutyrate and Vitamin D in Tuberculosis (TB)
Status: COMPLETED
Conditions: Pulmonary Tuberculosis
Interventions: DRUG: Active Sodium Phenylbutyrate and active cholecalciferol|DRUG: Placebo Sodium Phenylbutyrate plus active cholecalciferol|DRUG: Active Sodium Phenylbutyrate and placebo cholecalciferol|DRUG: Placebo Sodium Phenylbutyrate plus placebo cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ruxolitinib for the Treatment of Chronic Myelomonocytic Leukemia (CMML): A Phase 2 Expansion
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Myelomonocytic Leukemia|Leukemia
Interventions: DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Clinical Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Doses of IM-250 in Healthy Volunteers
Status: RECRUITING
Conditions: Herpes Simplex Virus
Interventions: DRUG: IM-250 (50 mg)|DRUG: IM-250 (100 mg)|DRUG: IM-250 (200 mg)|DRUG: IM-250 (400 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Compare BioChaperone Insulin Lispro Formulations With US Approved Humalog® and With EU Approved Humalog® in Patients With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Administration of BioChaperone insulin lispro reconstituted with Humalog® (IMP1)|DRUG: Administration of Ready-to-use BioChaperone insulin lispro (IMP2)|DRUG: Administration of US-approved Humalog® (IMP3)|DRUG: Administration of EU-approved Humalog® (IMP4)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Clinical Efficacy and Safety of Nuvastatic in Cancer Asthenia
Status: COMPLETED
Conditions: Asthenia|Cancer
Interventions: OTHER: Nuvastatic TM (C5OSEW5050ESA) 1000 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of Single-dose Seltorexant on Electrocardiogram Intervals in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Seltorexant|OTHER: Placebo Matched to Seltorexant|OTHER: Placebo Matched to Moxifloxacin|DRUG: Moxifloxacin Dose 1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Sm-EDTMP and Autologous Peripheral Blood Stem Cell Transplantation for Breast Cancer Patients With Bone Only Metastases
Status: COMPLETED
Conditions: Breast Cancer|Bone Metastases
Interventions: DRUG: 153 Sm-EDTMP|BEHAVIORAL: Questionnaire|PROCEDURE: Stem Cell Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Comparison of the Transversalis Fascia Plane Block With Ilioinguinal/Iliohypogastric Nerve Block
Status: COMPLETED
Conditions: Postoperative Pain|Inguinal Hernia Unilateral|Children, Only
Interventions: DRUG: Transversalis Fascia Plane Block|DRUG: Ilioinguinal/iliohypogastric Nerve Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GORE VIABAHN Endoprosthesis With Heparin Bioactive Surface in the Treatment of SFA Obstructive Disease (VIPER)
Status: COMPLETED
Conditions: Peripheral Vascular Diseases
Interventions: DEVICE: Treatment with the GORE VIABAHN Endoprosthesis with Heparin Bioactive Surface
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Single Nutritional Intervention Previous to a Critical Period of Fat Gain in University Students With Overweight and Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: Educational talk about physical activity and nutritional recommendations before a critical period of fat gain in university students
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Trial of SVTampons vs Glass Vaginal Dilators in Treatment of Vaginismus
Status: UNKNOWN
Conditions: Vaginismus
Interventions: DEVICE: Simple Vaginal Tampon|DEVICE: Glass Vaginal Trainer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Continuous Saphenous Nerve Block to Supplement a Continuous Sciatic Nerve Block After Ankle Surgery
Status: COMPLETED
Conditions: Orthopedic Surgery of Lower Extremity
Interventions: DEVICE: 0.2% ropivacaine|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-PD-1 and VEGF Bispecific Antibody AK112 in Combination With Chemotherapy in Patients With ES-SCLC
Status: COMPLETED
Conditions: SCLC, Extensive Stage
Interventions: DRUG: AK112|DRUG: Etoposide|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Orally Administered Medication When Taken in Conjunction With Pramlintide
Status: COMPLETED
Conditions: Diabetes Mellitus, Non-Insulin-Dependent
Interventions: DRUG: Pramlintide acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Fluoride Varnish and CPP-ACP on Oral and Salivary Symptoms During Chemotherapy
Status: COMPLETED
Conditions: Mucositis|Dry Mouth|Infection
Interventions: DRUG: Fluoride varnish|OTHER: Oral Hygiene|DRUG: CPP-ACP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oral Iron vs. Placebo in Newly Diagnosed Gynecologic Oncology Patients Who Are Surgical Candidates.
Status: COMPLETED
Conditions: Ovarian Cancer|Cervical Cancer|Uterine Cancer|Anemia
Interventions: OTHER: Oral Ferrous Fumarate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Quantitative Analysis of Different Acupuncture Needle Manipulation to Treat Chronic Shoulder Pain
Status: COMPLETED
Conditions: Shoulder Pain
Interventions: PROCEDURE: "Dragon and Tiger warring" in lifting and thrusting|PROCEDURE: "Dragon and Tiger warring" in twisting-rotating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: BE Study Budesonide 80 μg and Formoterol Fumarate Dihydrate 4.5 μg Inhalation Product in Asthma Patient
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Budesonide 80 μg and Formoterol Fumarate Dihydrate 4.5 μg|DRUG: Symbicort, 80 Mcg-4.5 Mcg/Inh Inhalation Aerosol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Phase III Study of Decitabine +/- Hydroxyurea (HY) Versus HY in Advanced Proliferative CMML
Status: COMPLETED
Conditions: MDS
Interventions: DRUG: Decitabine|DRUG: HYDROXYUREA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 68 Ga PSMA PET/MRI for Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: 68Ga-PSMA-11 PET/MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Measuring the Influence of Kefir on Children's Stools on Antibiotics (MILK)
Status: COMPLETED
Conditions: Respiratory Tract Infections
Interventions: OTHER: Kefir|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Therapy of PD-1 Blockade Combined With Chemotherapy for Esophageal Carcinoma
Status: RECRUITING
Conditions: Esophageal Carcinoma|Neoadjuvant Immunotherapy
Interventions: DRUG: PD-1 blockade|DRUG: Albumin paclitaxel|DRUG: Carboplatin/Nedaplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Letrozole Combined With Anlotinib Hydrochloride in the Treatment of Platinum-resistant Recurrent Ovarian Cancer
Status: UNKNOWN
Conditions: Platinum-resistant Recurrent Ovarian Cancer
Interventions: DRUG: Letrozole combined with anlotinib hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Memory Skills in Patients Receiving Radiation Therapy for Brain Metastases
Status: COMPLETED
Conditions: Cognitive/Functional Effects|Metastatic Cancer|Radiation Toxicity
Interventions: PROCEDURE: management of therapy complications|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Hydroxyurea Therapy for Neurological and Cognitive Protection in Pediatric Sickle Cell Anemia in Uganda ( BRAINSAFE-II )
Status: ACTIVE_NOT_RECRUITING
Conditions: Sickle Cell Anemia in Children
Interventions: DRUG: Hydroxyurea
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients With Acute Respiratory Failure and Sepsis
Status: RECRUITING
Conditions: Acute Respiratory Failure
Interventions: DRUG: IV Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fiber Fermentation Kinetics Inside the Gut, and Utilization of Bacterial Metabolites
Status: COMPLETED
Conditions: Metabolism|Dietary Fiber|Intestine
Interventions: DIETARY_SUPPLEMENT: fructo- and galacto-oligosaccharides
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase II Front-line Ponatinib in Adult Philadelphia+/BCR-ABL+ Acute Lymphoblastic Leukemia.
Status: COMPLETED
Conditions: Philadelphia Positive|BCR-ABL Positive|Acute Lymphoblastic Leukemia
Interventions: DRUG: Ponatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pelvic Floor Physical Therapy to Reduce Stress Urinary Incontinence After Holmium Laser Enucleation of the Prostate
Status: ENROLLING_BY_INVITATION
Conditions: Prostatic Hyperplasia|Stress Urinary Incontinence
Interventions: BEHAVIORAL: Pelvic floor physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Antiretroviral Treatment on Pharmacokinetics and Pharmacodynamics of Thienopyridines in Healthy Volunteers and HIV Patients
Status: TERMINATED
Conditions: Hiv
Interventions: DRUG: Clopidogrel 300Mg Tablet|DRUG: Prasugrel 60Mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ifosfamide, Carboplatin, Etoposide, and SGN-30 in Treating Young Patients With Recurrent Anaplastic Large Cell Lymphoma
Status: TERMINATED
Conditions: Anaplastic Large Cell Lymphoma|Recurrent Childhood Anaplastic Large Cell Lymphoma
Interventions: BIOLOGICAL: monoclonal antibody SGN-30|DRUG: therapeutic hydrocortisone|DRUG: ifosfamide|DRUG: carboplatin|DRUG: etoposide|DRUG: methotrexate|DRUG: cytarabine|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Protocol for the Validation of UAud in a Clinical Setting.
Status: RECRUITING
Conditions: Hearing Loss, Sensorineural|Hearing Impairment, Sensorineural
Interventions: DIAGNOSTIC_TEST: uAud|DIAGNOSTIC_TEST: Traditional audiometry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Sleep Quality in Patients Undergoing Thoracic Surgery With Different Types of Anesthesia Management
Status: COMPLETED
Conditions: General Anesthesia, Thoracic Epidural Anesthesia
Interventions: DRUG: general anesthesia combined with dexmedetomidine infusion|PROCEDURE: general anesthesia combined with TEA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Intralymphatic Allergen-specific Immunotherapy
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: ALK Alutard Birch and/or 5-grasses|DRUG: ALK Diluent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Sodium Bicarbonate in Patients Treated With Topiramate
Status: UNKNOWN
Conditions: Epilepsy|Metabolic Acidosis|Tubular Acidosis; Renal
Interventions: DIETARY_SUPPLEMENT: Sodium bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib Concurrent With Yttrium-90 Transarterial Radioembolization in Patients With Advanced Hepatocellular Cancer
Status: WITHDRAWN
Conditions: Hepatocellular Cancer
Interventions: DRUG: Sorafenib|RADIATION: yttrium-90 radioembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Evaluation During Follicle Aspiration: Comparison of Two Sedation Protocols
Status: WITHDRAWN
Conditions: Pain
Interventions: DRUG: Low dose of alfentanil hydrochloride|DRUG: Normal dose of alfentanil hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Treatment (Talazoparib Plus Avelumab) for Stage IV or Recurrent Non-Squamous Non-Small Cell Lung Cancer With STK11 Gene Mutation (A LUNG-MAP Treatment Trial)
Status: COMPLETED
Conditions: Advanced Lung Non-Squamous Non-Small Cell Carcinoma|Recurrent Lung Non-Squamous Non-Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: DRUG: Avelumab|DRUG: Talazoparib|DRUG: Talazoparib Tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vinblastine/Prednisone Versus Single Therapy With Cytarabine for Langerhans Cell Histiocytosis (LCH)
Status: RECRUITING
Conditions: Langerhans Cell Histiocytosis
Interventions: DRUG: Cytarabine|DRUG: Vinblastine/prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
Status: RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Early Stage Triple-Negative Breast Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab|OTHER: Patient Observation|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|OTHER: Questionnaire Administration|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irinotecan and Docetaxel in Treating Patients With Metastatic or Locally Recurrent Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: docetaxel|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation of Lacrimal Punctal Changes by Anterior Segment Optical Coherence Tomography AS-OCT After Topical Combined Antibiotics and Steroids Treatment in Cases of Inflammatory Punctual Stenosis
Status: COMPLETED
Conditions: Ophthalmopathy , Lacrimal System
Interventions: DRUG: 5 mg chloramphenicol, 1 mg dexamethasone sodium phosphate, 0.25 mg tetryzoline hydrochloride, 2 mg Hydroxypropyl Methyl Cellulose, 10 mg α-tocopherol acetate and 8 mg macrogol 400).|DRUG: sodium hyaluronate, polyethylene and propylene glycol based) three times daily for three months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: X-396 Capsule in Advanced NSCLC Patients With ROS1 Gene Rearrangement
Status: UNKNOWN
Conditions: Lung Cancer|ROS1 Gene Rearrangement
Interventions: DRUG: X-396 Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of the Pill Chemotherapy, Cabozantinib, to the Standard Immune Therapy Nivolumab Compared to Standard Chemotherapy for Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Lung Non-Squamous Non-Small Cell Carcinoma|Recurrent Lung Non-Squamous Non-Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Cabozantinib S-malate|PROCEDURE: Computed Tomography|DRUG: Docetaxel|PROCEDURE: Echocardiography|DRUG: Gemcitabine Hydrochloride|DRUG: Nab-paclitaxel|BIOLOGICAL: Nivolumab|DRUG: Paclitaxel|BIOLOGICAL: Ramucirumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study in Patients With Refractory Chronic Lower Limb Neuropathic Pain and/or Back Neuropathic Pain.
Status: TERMINATED
Conditions: Pain, Neuropathic
Interventions: OTHER: Spinal Cord Stimulation, association of both (DUAL), Dorsal Root Ganglion stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Proof-of-concept Study of NSAID Hydrogel Patch in Treatment of Acute Pain
Status: TERMINATED
Conditions: Ankle Sprain
Interventions: DRUG: Esflurbiprofen Hydrogel Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Investigate the Effectiveness and Safety of Org 3236 (Etonogestrel) Tablets in Men With Urinary Complaints Suggestive of a Benign Enlargement of the Prostate (304001)(P05806)
Status: TERMINATED
Conditions: Benign Prostatic Hyperplasia (BPH)
Interventions: DRUG: etonogestrel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: "REDUCE" - A Clinical Research Study To Reduce The Incidence Of Prostate Cancer In Men Who Are At Increased Risk
Status: COMPLETED
Conditions: Neoplasms, Prostate
Interventions: DRUG: Dutasteride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Magnetic Resonance Imaging of Medial Meniscal Posterior Root Tear
Status: COMPLETED
Conditions: Medial Meniscus, Posterior Horn Derangement
Interventions: RADIATION: Magnetic Resonance Imaging of the knee|PROCEDURE: Knee Arthroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Flavopiridol Plus Radiation Therapy Followed By Gemcitabine Hydrochloride in Treating Patients With Locally Advanced, Unresectable Pancreatic Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage II Pancreatic Cancer|Stage III Pancreatic Cancer|Stage IV Pancreatic Cancer
Interventions: DRUG: alvocidib|DRUG: gemcitabine hydrochloride|RADIATION: 3-dimensional conformal radiation therapy|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strength Training in Improving Pain and Quality of Life in Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Plasma Cell Myeloma
Interventions: DEVICE: FitBit|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|OTHER: Resistance Training|BEHAVIORAL: STEPS to Enhance Physical Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate Safety and Efficacy of BEY1107 in Combination With Capecitabine in Patients With Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: BEY1107|COMBINATION_PRODUCT: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for Colorectal Laterally Spreading Lesions.
Status: RECRUITING
Conditions: Neoplasms, Colorectal
Interventions: PROCEDURE: Endoscopic mucosal resection (EMR)|PROCEDURE: Endoscopic submucosal dissection (ESD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: CKD-337 Drug Interaction Study
Status: COMPLETED
Conditions: Dyslipidemia (Fredrickson Type Ⅱa)|Dyslipidemia (Fredrickson Type Ⅱb)
Interventions: DRUG: Fenofibrate|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Neuroprotective Effects of Dexmedetomidine During Brain Surgery
Status: COMPLETED
Conditions: Brain Tumor|Cerebrovascular Disorders
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Rehabilitation and Coronary Artery Disease
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease|Atherosclerosis
Interventions: BEHAVIORAL: Exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: tDCS as Add on Therapy for Treatment of Tobacco Dependence by Standardized Behaviour Therapy
Status: UNKNOWN
Conditions: Smoking Cessation|Tobacco Dependence
Interventions: OTHER: tDCS|BEHAVIORAL: standardised behavioural therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: EFFECT OF BUFFERED LOCAL ANESTHESIA ON PAIN IN ARETERIOVENOUS FISTULA
Status: UNKNOWN
Conditions: Pain, Procedural|Pain, Postoperative|Satisfaction, Patient
Interventions: PROCEDURE: buffered anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of a New Thermostable Formulation of FLOLAN in Japanese Subjects
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DRUG: FLOLAN injection with currently marketed diluent|DRUG: FLOLAN injection with reformulated diluent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VASO-AM :Impact of Oral Appliance Therapy on Endothelial Function in Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea Syndrome
Interventions: DEVICE: AMO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE