pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Relative Bioavailability of Single Doses of Dabigatran Etexilate in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Dabigatran etexilate|DRUG: Rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Outcome After SRS or WBRT in Patients With Multiple Brain Metastases (CAR-Study B)
Status: ACTIVE_NOT_RECRUITING
Conditions: Neoplasm Metastasis
Interventions: RADIATION: Gamma Knife radiosurgery|RADIATION: Whole Brain Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of OT-101+Artemisinin in Hospitalized COVID-19 Subjects
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: OT-101|DRUG: Artemisinin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Walking and Blood Pressure in Older Adults With Respiratory Impairment.
Status: ENROLLING_BY_INVITATION
Conditions: Respiratory Impairment|Elevated Blood Pressure|Physical Inactivity
Interventions: OTHER: Increased lifestyle walking (intervention)|OTHER: Health education only (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Conservative Interventions in the Treatment of Trigger Finger
Status: RECRUITING
Conditions: Trigger Finger|Stenosing Tenosynovitis
Interventions: OTHER: Experimental: Extracorporeal Shock Wave Therapy|OTHER: Trigger Finger Splint|OTHER: Extracorporeal Shock Wave Therapy+ Trigger Finger Splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Taste and Palatability in Fiber Supplements
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: Volcolon sugar free|DRUG: Metamucil Orange|DRUG: Psyllium Orange
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Computerized Facial Recognition for Automated Diagnosis of the Facio-Scapulo-Humeral Muscular Dystrophy (FSMHD)
Status: COMPLETED
Conditions: Facio-Scapulo-Humeral Dystrophy
Interventions: OTHER: Video recording
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Water and Electrolytes Content in HYpertension (WHYSKI) in the SKIn
Status: RECRUITING
Conditions: Hyperaldosteronism|Hypertension|Aldosterone-producing Adenoma|Aldosteronism|Aldosterone Disorder|Essential Hypertension|Bilateral Adrenal Hyperplasia|Conn Adenoma
Interventions: PROCEDURE: Skin Biopsy|PROCEDURE: Video-laparoscopic adrenalectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Once-Daily Oral Dose of BeneFlax to Healthy Older Adults
Status: COMPLETED
Conditions: Oxidative Stress|Inflammation|Aging|Pain
Interventions: DIETARY_SUPPLEMENT: secoisolariciresinol diglucoside, vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optimizing Dosing Regimen of Piperacillin/Tazobactam for Nosocomial Pneumonia
Status: UNKNOWN
Conditions: Nosocomial Pneumonia
Interventions: DRUG: C Group|DRUG: E Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Diabetes Self-management Education and Support on Glycemic Control Among Patients With Type 2 Diabetic
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: what's app ongoing support|BEHAVIORAL: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Micronet Covered Stent in in Arterial Locations Beyond the Carotid Bifurcation - FLOW-Guard Study
Status: UNKNOWN
Conditions: Peripheral Vascular Diseases
Interventions: DEVICE: MicroNet covered stent implantation in the increased risk arterial lesions beyond the carotid bifurcation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Xolair Interventional Study in ASD Patients With Comorbid Atopy
Status: WITHDRAWN
Conditions: Autism Spectrum Disorder|Atopy
Interventions: DRUG: Omalizumab Injection [Xolair]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Rhomboid Intercostal and Subserratus Plane Block in Breast Cancer Surgeries
Status: COMPLETED
Conditions: Breast Cancer Surgery|Postoperative Analgesia
Interventions: DRUG: Rhomboid Intercostal and Subserratus Plane Block with local anesthetic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of an Online, Self-administered Cognitive Screening Tool in Older Patients Undergoing Ambulatory Surgery
Status: COMPLETED
Conditions: Delirium in Old Age|Alzheimer Disease|Mild Cognitive Impairment|Neurocognitive Disorders
Interventions: OTHER: Brain Health Assessment|OTHER: Demographics questionnaire|OTHER: PHQ-2|OTHER: AFT|OTHER: GAI-SF|OTHER: pain VAS|OTHER: IADL|OTHER: FAM CAM|OTHER: 4AT|OTHER: BHA Usability Survey|OTHER: Clinical Frailty Scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ablation of Focal Activation in Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation|Atrial Fibrillation, Persistent|Arrhythmia|Arrhythmias, Cardiac|Cardiac Arrhythmia
Interventions: PROCEDURE: Pulmonary vein isolation|DIAGNOSTIC_TEST: RETRO-Mapping without adjunctive ablation|PROCEDURE: Adjunctive ablation guided by RETRO-Mapping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Frankincense Supplements and Inflammation
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Frankincense essential oil + boswellic acid supplement|DIETARY_SUPPLEMENT: Frankincense essential oil supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Interventions for Lifestyle Changes to Promote Weight Reduction, a Randomized Controlled Trial in Primary Health Care
Status: COMPLETED
Conditions: Overweight/Obesity
Interventions: OTHER: Intensive lifestyle counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Haplo-cord HCT vs. Haplo-HCT for T-ALL Patients
Status: RECRUITING
Conditions: Acute T Cell Lymphoblastic Leukemia|Haploidentical Hematopoietic Stem Cell Transplantation|Cord Blood
Interventions: BIOLOGICAL: Haplo-cord HCT|BIOLOGICAL: Haplo-HCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraspinal Pressure Monitoring for Acute Traumatic Spinal Cord Injury: A Validation Study
Status: RECRUITING
Conditions: Spinal Cord Injuries|Spine Injury
Interventions: PROCEDURE: Insertion of Intraspinal pressure monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Exploring the PK of Different Doses of Naltrexone in Patients With AUD
Status: RECRUITING
Conditions: AUD
Interventions: DRUG: Naltrexone implant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Fibromyalgia on Outcomes of Transforaminal Epidural Steroid Injection Treatment in Lumbar Radicular Pain
Status: UNKNOWN
Conditions: Herniated Disk Lumbar|Fibromyalgia
Interventions: PROCEDURE: transforaminal epidural steroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fecal Calprotectin Collection Protocol
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases|Irritable Bowel Syndrome|Ulcerative Colitis|Crohn Disease|Indeterminate Colitis|Chronic Diarrhea|Celiac Disease|Diverticulitis|Abdominal Pain|Distension|Weight Loss|Food Intolerance|Constipation
Interventions: DIAGNOSTIC_TEST: Stool collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: FAECAL MICROBIOTA TRANSPLANTATION IN OBESITY
Status: UNKNOWN
Conditions: Obesity, Morbid
Interventions: OTHER: Fecal microbiota transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Paliperidone Blood Concentrations in Patients With Schizophrenia After Administration of Paliperidone Palmitate
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: paliperidone palmitate 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serum Progesterone Levels on the Day of Frozen Embryo Transfer (FET) and Pregnancy Outcomes
Status: COMPLETED
Conditions: Infertility|Infertility, Female|IVF
Interventions: DIAGNOSTIC_TEST: Measurement of serum progesterone on the day of FET
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pragmatic Clinical Trials in Scleroderma
Status: UNKNOWN
Conditions: Scleroderma, Systemic|Sclerosis, Systemic
Interventions: OTHER: Interstitial lung disease induction algorithm|OTHER: Pulmonary arterial hypertension algorithm|OTHER: Raynaud's phenomenon algorithm|OTHER: Digital ulcer algorithm|OTHER: Inflammatory arthritis algorithm|OTHER: Gastroesophageal reflux algorithm|OTHER: Bacterial overgrowth algorithm|OTHER: Constipation algorithm|OTHER: Skin involvement algorithm|OTHER: Pain algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TKA Melatonin and Sleep Quality
Status: COMPLETED
Conditions: Arthroplasty|Replacement|Knee|Sleep Initiation and Maintenance Disorders
Interventions: DIETARY_SUPPLEMENT: Melatonin 5 mg|DIETARY_SUPPLEMENT: Placebo (Vitamin C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Anesthetic Efficacy of %4Alexadricaine Versus %2 Mepicaine-L in Children
Status: COMPLETED
Conditions: Local Anesthesia
Interventions: DRUG: 4% Articaine Hydrochloride with 1:100,000 Adrenaline|DRUG: 2% Mepivacaine Hydrochloride with 1:20,000 Levonordefrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Gather Information About Overall Occurrence and New Cases of Dravet and Lennox-Gastaut Syndromes in Children, Teenagers and Adults in Spain
Status: RECRUITING
Conditions: Dravet Syndrome (DS)|Lennox-Gastaut Syndrome (LGS)
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Glycemic Emergency Management (GEM); An App for Rapid Response to Hypoglycemic and Hyperglycemic Situations
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus
Interventions: OTHER: Experimental Group instructions for glucose management via App|OTHER: Placebo Comparator general instructions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Investigational Scan (MR DENSE) in Detecting Early Chemotherapy-Related Liver Injury Before Surgery in Patients With Resectable Colorectal Liver Metastases
Status: WITHDRAWN
Conditions: Colorectal Carcinoma Metastatic in the Liver
Interventions: PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: DEFIANCE: RCT of ClotTriever System Versus Anticoagulation In Deep Vein Thrombosis
Status: RECRUITING
Conditions: Venous Thromboembolism|Deep Venous Thrombosis|Post-Thrombotic Syndrome
Interventions: DEVICE: ClotTriever System|DRUG: Commercially available/market approved anticoagulation medication including but not limited to: Heparin Sodium, Coumadin, Rivaroxaban, Apixaban, etc.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Treatment of Skeletal Anterior Open Bite by Two Appliances
Status: COMPLETED
Conditions: Open Bite
Interventions: DEVICE: Bionator|DEVICE: Removable Appliance with Posterior Bite Planes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rilonacept to Improve Artery Function in Patients With Atherosclerosis
Status: COMPLETED
Conditions: Coronary Artery Disease|Atherosclerosis|Inflammation|Endothelial Dysfunction
Interventions: DRUG: Rilonacept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Processing In Relation To Breathing
Status: RECRUITING
Conditions: Central Sensitisation|Pain
Interventions: BEHAVIORAL: Paced Resonance Frequency Breathing|BEHAVIORAL: Paced Breathing at Natural Frequency|OTHER: Heat Stimulations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of TBI-1301 (NY-ESO-1 Specific TCR Gene Transduced Autologous T Lymphocytes) in Patients With Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: NY-ESO-1 Expressing Solid Tumors in HLA-A2 Positive Patients|Synovial Sarcoma|Melanoma|Esophageal Cancer|Ovarian Cancer|Lung Cancer|Bladder Cancer|Liver Cancer
Interventions: DRUG: Cyclophosphamide|BIOLOGICAL: TBI-1301|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating ISM8207 in Participants With Advanced Solid Tumors and Relapsed/Refractory B-Cell Lymphoma
Status: RECRUITING
Conditions: Advanced Solid Tumors|Relapsed/Refractory B-cell Lymphoma
Interventions: DRUG: ISM8207
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spermotrend in the Treatment of Male Infertility
Status: COMPLETED
Conditions: Male Infertility
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Spermotrend
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Microplasmin Intravitreal Injection for Non-Surgical Treatment of Focal Vitreomacular Adhesion. The MIVI-TRUST (TG-MV-007) Trial.
Status: COMPLETED
Conditions: Vitreomacular Adhesion
Interventions: DRUG: Ocriplasmin 125µg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Citicholine-Amantadine Trial in Traumatic Brain Injury
Status: COMPLETED
Conditions: Intensive Care Unit
Interventions: DRUG: Citicholine|DRUG: Amantadine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics (PK), and Activity of ATYR1940 in Participants With Muscular Dystrophy - Study Extension
Status: COMPLETED
Conditions: Facioscapulohumeral Muscular Dystrophy
Interventions: BIOLOGICAL: ATYR1940
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Substance Misuse To Psychosis for Stimulants
Status: RECRUITING
Conditions: Stimulant Use With Stimulant-Induced Psychotic Disorder (Diagnosis)|Schizophrenia and Related Disorders|Stimulant Dependence|Stimulant Abuse|Pharmacotherapy
Interventions: DRUG: Aripiprazole|DRUG: Paliperidone|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Slow Continuous Ultrafiltration Using Central vs Peripheral Line: Feasibility of Implementation, Safety and Efficacy in Acute Heart Failure Syndromes.
Status: UNKNOWN
Conditions: Heart Failure
Interventions: PROCEDURE: Peripheral line|PROCEDURE: Central line vein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Use of Smart Mobile Application in Mothers With Cerebral Palsy Children
Status: NOT_YET_RECRUITING
Conditions: Cerebral Palsy
Interventions: OTHER: nursing consultancy with smartphone support
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Multistrain Probiotic for Functional Constipation
Status: UNKNOWN
Conditions: Functional Constipation
Interventions: DIETARY_SUPPLEMENT: High dose Multistrain probiotic, 100 billion cfu/day|DIETARY_SUPPLEMENT: Low dose Multistrain probiotic, 15 billion cfu/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Traditional Chinese Medicine Ultrasonic Atomization Treatment for Dry Eye Disease
Status: RECRUITING
Conditions: Dry Eye Syndromes
Interventions: DRUG: TCM ultrasonic atomization treatment with herbal Compound Decoction (CD)|DRUG: TCM ultrasonic atomization treatment with Dendrobii Caulis (DC)|DRUG: TCM ultrasonic atomization treatment with Houttuynia Cordata (HC)|DRUG: Placebo TCM ultrasonic atomization treatment (PA)|DRUG: Artificial Tears (AT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OrthoPulse 2.0 and 2.1 Feasibility Evaluation
Status: UNKNOWN
Conditions: Malocclusion
Interventions: DEVICE: OrthoPulse 2.0|DEVICE: OrthoPulse 2.1|DEVICE: Invisalign 3.5 Day Wear|DEVICE: Fixed Orthodontic Appliances (Braces)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Observational Study of Clinician and Patient-reported Outcomes in Patients With Dermatological Conditions
Status: ENROLLING_BY_INVITATION
Conditions: Atopic Dermatitis|Dermatology|Vitiligo|Alopecia Areata|Hidradenitis Suppurativa|Psoriasis
Interventions: OTHER: N/A This is an observational study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TIL Therapy in Non-small-cell Lung Cancer (NSCLC) Patients
Status: NOT_YET_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Combination of TIL Transfer and low dose IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY2922470 in Healthy Participants and Participants With Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo|DRUG: LY2922470
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Naltrexone on Active Crohn's Disease
Status: COMPLETED
Conditions: Inflammation|Crohn's Disease
Interventions: DRUG: Naltrexone-HCl|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Graded Motor Imagery on Pain and Function in Individuals With Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis|Limitation, Mobility
Interventions: OTHER: Graded Motor Imagery (GMI)|OTHER: Transcutaneous Electrical Nerve Stimulation (TENS)|OTHER: Conventional Physiotherapy Program|OTHER: Home Exercise Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of an Arabic Articulatory Error Remediation Software Program in Patients With Velopharyngeal Valve Dysfunction:
Status: COMPLETED
Conditions: Velopharyngeal Insufficiency|Articulation Disorders|Hypernasality Syndrome Due to Velopharyngeal Weakness
Interventions: BEHAVIORAL: Arabic Articulatory Error Remediation software program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Effect of Natural Killer Cell and Doublet Chemotherapy in Advanced NSCLC as the 1st Line Treatment
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: ANKL(Ex vivo-expanded NK cell enriched lymphocytes)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of CBI on Depression and Adherence in HIV Infected Adolescents
Status: COMPLETED
Conditions: Medication Nonadherence|Depression|HIV Infections
Interventions: BEHAVIORAL: Psychoeducation, problem solving and rehearsal (cognitive behavioural intervention)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Heat Loss Prevention in Delivery Room Using a Polyethylene Cap
Status: COMPLETED
Conditions: Hypothermia, Preterm Infants
Interventions: DEVICE: Polyethylene cap|DEVICE: Polyethylene wrap|OTHER: conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Celecoxib in Treating Patients With Head and Neck Cancer That Can Be Removed By Surgery
Status: UNKNOWN
Conditions: Head and Neck Cancer
Interventions: DRUG: celecoxib|GENETIC: microarray analysis|GENETIC: protein expression analysis|OTHER: immunoenzyme technique|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|PROCEDURE: biopsy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Ontamalimab as Induction Therapy in Participants With Moderate to Severe Crohn's Disease (CARMEN CD 305)
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: Ontamalimab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Iobitridol in Patients Undergoing Multislice Computed Tomography (CT) Abdominal Angiography
Status: COMPLETED
Conditions: Diagnostic Imaging
Interventions: DRUG: Iobitridol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Anakinra for Inflammatory Pustular Skin Diseases
Status: COMPLETED
Conditions: Sneddon-Wilkinson|Acrodermatitis Continua of Hallopeau|Pustular Psoriasis|Palmoplantar Pustulosis
Interventions: DRUG: Anakinra
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Maolactin on Gastrointestinal Tract (GIT) Health
Status: RECRUITING
Conditions: Gastrointestinal Dysfunction
Interventions: DRUG: High Dose Maolactin|DRUG: Low Dose Maolactin|DRUG: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Debridement To Treat The Traumatic Corneal Abrasion
Status: UNKNOWN
Conditions: Corneal Abrasion
Interventions: BIOLOGICAL: corneal debridement of corneal abrasion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Subgingival Instrumentation on Jaw Symptoms of Probable Bruxers Among Patients With Periodontitis
Status: NOT_YET_RECRUITING
Conditions: Periodontitis|Bruxism
Interventions: OTHER: Subgingival instrumentation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Clinical Activity of Defactinib in Combination With Avelumab in Epithelial Ovarian Cancer
Status: TERMINATED
Conditions: Epithelial Ovarian Cancer
Interventions: DRUG: Part A - VS-6063|DRUG: Part A - Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Multiple Doses of JNJ-56021927 on the Pharmacokinetics of Multiple Cytochrome P450 and Transporter Substrates in Participants With Castration-Resistant Prostate Cancer
Status: RECRUITING
Conditions: Prostatic Neoplasms, Castration-Resistant
Interventions: DRUG: JNJ 56021927|DRUG: Drug Cocktail|DRUG: Pioglitazone|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Stereotactic Ablative Radiotherapy for Pancreatic Ductal Adenocarcinoma
Status: UNKNOWN
Conditions: Resectable Pancreatic Adenocarcinoma|Borderline Resectable Pancreatic Adenocarcinoma
Interventions: RADIATION: Stereotactic Ablative Body Radiotherapy (SABR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Research Study Looking at How Well Semaglutide Tablets Taken Once Daily Work in People Who Have a Body Weight Above the Healthy Range
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: DRUG: Semaglutide|DRUG: Placebo semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Nalbuphine is a Comparable Safer Alternative to Fentanyl for Intraoperative Pain Management During Uterine Exteriorization
Status: COMPLETED
Conditions: Pain, Acute
Interventions: DRUG: intrathecal drug injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Uterovaginal Plexus Block With Articaine for Intrauterine Device Placement Patients Who Are Indicated for the Use of Copper IUD as a Contraceptive Method Will be Invited to Participate in This Research.
Status: UNKNOWN
Conditions: Contraception|IUD|Anesthesia, Local
Interventions: DRUG: Articaine Hydrochloride 40 MG/ML|DRUG: Mepivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study About the Impact of Two Oil Emulsions Administered Intravenously on Severe Acute Pancreatitis
Status: UNKNOWN
Conditions: Severe Acute Pancreatitis
Interventions: DRUG: Fat emulsion with MCT, LCT, olive oil and omega 3 fatty acids|DRUG: Fat emulsion with MCT and LCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Trial to Incentivise Adherence for Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Diabetes Educational Program (DEP)|BEHAVIORAL: DEP + Process Incentive|BEHAVIORAL: DEP + Outcome Incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Proprietary Botanical Blend on Glycemic Control and Post-prandial Carbohydrate Absorption
Status: UNKNOWN
Conditions: Hyperglycemia|Carbohydrate|Insulin Resistance|Malabsorption
Interventions: DIETARY_SUPPLEMENT: Proprietary Botanical Blend|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Effectiveness of Gadopiclenol for Evaluation of Adult Congenital Heart Anatomy and Hemodynamics
Status: NOT_YET_RECRUITING
Conditions: Congenital Heart Disease
Interventions: DRUG: Gadopiclenol|DRUG: Gadobenate dimeglumine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Changes in Oxygen Saturation in Two Exercise Modalities
Status: COMPLETED
Conditions: Muscle Oxigenation|Strength
Interventions: DEVICE: Iso inertial|DEVICE: Conventional machine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immunogenicity and Safety of Kinrix + (Measles Mumps Rubella) MMR Vaccine With and Without Varicella Vaccine in Healthy Children 4-6 Years
Status: COMPLETED
Conditions: Tetanus|Acellular Pertussis|Diphtheria
Interventions: BIOLOGICAL: GSK Biologicals'Kinrix®|BIOLOGICAL: Merck and Company's MMRII|BIOLOGICAL: Merck and Company's Varivax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Upregulation of Alpha-1 Receptors Upon Septic Shock?
Status: TERMINATED
Conditions: Septic Shock
Interventions: DRUG: Clonidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Assess the Relative Potency of Multiple Oral Doses of LUM001 and SHP626 in Overweight and Obese Adults as Assessed by Fecal Bile Acid Excretion
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Placebo|DRUG: Maralixibat|DRUG: Volixibat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Diffusion -and Perfusion Weighted MRI for Response Prediction of Symptomatic Leiomyomas Following Uterine Artery Embolization
Status: ACTIVE_NOT_RECRUITING
Conditions: Leiomyomas
Interventions: PROCEDURE: Diffusion -and perfusion weighted MRI including iv contrast agent injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of the Effects of Tapentadol and Oxycodone on Gastrointestinal and Colonic Transit in Humans
Status: COMPLETED
Conditions: Effects of 2 Mu-opiates on Gastrointestinal Transit
Interventions: DRUG: Tapentadol|DRUG: Oxycodone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase IIa Study of Sotatercept on Bone Mass and Turnover in Patients With Multiple Myeloma
Status: WITHDRAWN
Conditions: Multiple Myeloma
Interventions: DRUG: Sotatercept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of LCI699 for the Treatment of Patients With Cushing's Disease
Status: COMPLETED
Conditions: Cushings Disease
Interventions: DRUG: osilodrostat|DRUG: LCI699 matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Healing Opioid Misuse and Pain Through Engagement (HOPE) Trial
Status: RECRUITING
Conditions: Opioid Use Disorder|Chronic Pain
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy + Mindfulness Based Relapse Prevention (ACT + MBRP)|BEHAVIORAL: Enhance Usual Care (EUC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Blood Level of Bimekizumab Injected Subcutaneously Either by a Prefilled Syringe or by an Auto-injector in Adult Healthy Volunteer Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Bimekizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy, Safety, and Tolerability Study of Sotagliflozin as Adjunct Therapy in Adult Patients With Type 1 Diabetes Mellitus Who Have Inadequate Glycemic Control With Insulin Therapy
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Placebo|DRUG: Sotagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Gemcitabine and Vinorelbine in Soft Tissue Sarcomas
Status: COMPLETED
Conditions: Sarcoma, Soft Tissue
Interventions: DRUG: gemcitabine|DRUG: vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study to Evaluate the Safety, Tolerability and Efficacy of MEDI4736 (Durvalumab) With Tremelimumab in Head and Neck Cancer
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: BIOLOGICAL: MEDI4736|BIOLOGICAL: tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of PF-04620110 As A Modified-Release Formulation In Healthy Overweight Or Obese Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-04620110 or Placebo|DRUG: PF-04620110 or Placebo|DRUG: PF-04620110 or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Psychological Screening and Nursing of Twin Pregnancy
Status: RECRUITING
Conditions: Twin; Complicating Pregnancy|Psychology
Interventions: OTHER: Guided self help|OTHER: Problem solving therapy|OTHER: Face to face PST course|OTHER: Professional psychological intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase II Clinical Trial of Docetaxel, Oxaliplatin Combination Chemotherapy in Patients With Stage IIIB/IV Non-adenocarcinoma, Non-small Cell Lung Cancer (NSCLC) as Second-line Treatment
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung|Carcinoma, Squamous|Carcinoma, Large Cell
Interventions: DRUG: Docetaxel|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Study of a Novel JAK-inhibitor, INCB047986, Given in Patients With Advanced Malignancies
Status: TERMINATED
Conditions: Solid Tumor|Hodgkin's Lymphoma|NHL (Non-Hodgkin Lymphoma)|Pancreatic Cancer|Breast Cancer|UC (Ureter and Urethera)|Advanced Cancer|Metastatic Cancer
Interventions: DRUG: INCB047986|DRUG: INCB047986|DRUG: Gemcitabine|DRUG: nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intravenous Iron Administration in Hemodialysis Patients
Status: COMPLETED
Conditions: Chronic Renal Failure|Hemodialysis|Renal Anemia|Iron Deficiency Anemia
Interventions: DRUG: chondroitin sulfate-iron colloid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ropivacaine Complex Methylene Blue Fascia Iliaca Compartment Block on Analgesia in Patients Undergoing Hip Arthroplasty
Status: ENROLLING_BY_INVITATION
Conditions: Femoral Neck Disease
Interventions: DRUG: Ropivacaine combined with methylene blue for iliac fascia block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Clinical Trial of PRAX-114 in Participants With Post-Traumatic Stress Disorder
Status: TERMINATED
Conditions: Post-traumatic Stress Disorder|Post Traumatic Stress Disorder|Stress Disorder|Stress Disorders, Post-Traumatic|Trauma and Stressor Related Disorders|Mental Disorder
Interventions: DRUG: 60 mg PRAX-114 or 40 mg PRAX-114|DRUG: Placebo|DRUG: 40 mg PRAX-114
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Assessment by Pupil Dilation Reflex (PDR) and Pupillary Pain Index (PPI) in Response to Noxious Stimulation in Anesthetized Adults
Status: COMPLETED
Conditions: Nociceptive Pain|Monitoring, Intraoperative
Interventions: PROCEDURE: PDR measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Utility of Prenatal Whole Exome Sequencing
Status: COMPLETED
Conditions: Structural Anomalies|Cardiac Anomalies|Central Nervous System Anomalies|Thorax Anomalies|Genito-urinary Anomalies|Gastrointestinal Anomalies|Skeletal Anomalies|Multiple Anomalies
Interventions: DEVICE: Whole Exome Sequencing (WES)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of BIIB033 in Healthy Japanese Participants
Status: COMPLETED
Conditions: Central Nervous System (CNS) Demyelinating Disease|Multiple Sclerosis
Interventions: BIOLOGICAL: BIIB033|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hypertonic Saline Resuscitation in Trauma Patients After Hemorrhage Control
Status: TERMINATED
Conditions: Abdominal Injuries
Interventions: DRUG: Sodium Chloride [3%]|DRUG: Sodium Chloride [0.9%]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Anxiolysis and Pain Associated With Retrobulbar Eye Block for Cataract Surgery : Melatonin Versus Gabapentin
Status: COMPLETED
Conditions: Anxiety|Pain
Interventions: DRUG: Melatonin|DRUG: Gabapentin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SarS-Cov-2 Viral Infection (COVID-19) in Patients With Chronic Inflammatory Rheumatism
Status: TERMINATED
Conditions: Spondyloarthritis|Rheumatoid Arthritis|Covid19
Interventions: BIOLOGICAL: blood tests|BIOLOGICAL: Nasopharyngeal swabs|BIOLOGICAL: Stools
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Efficacy and Safety of Trastuzumab Emtansine (Trastuzumab-MCC-DM1) vs. Trastuzumab (Herceptin®) and Docetaxel (Taxotere®) in Patients With Metastatic HER2-positive Breast Cancer Who Have Not Received Prior Chemotherapy for Metastatic Disease
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab emtansine [Kadcyla]|DRUG: Trastuzumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of XAF5 Gel Applied to Skin of Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: XAF5, concentration A|DRUG: XAF5, concentration B|DRUG: XAF5, concentration C|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CAR - γ δ T Cells in the Treatment of Relapsed and Refractory CD7 Positive T Cell-derived Malignant Tumors
Status: UNKNOWN
Conditions: CAR|Malignant Tumors
Interventions: DRUG: Chimeric antigen receptor modified γδ T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity, Inactivated Split Influenza Vaccine, Using the Strain Composition 2009/2010
Status: COMPLETED
Conditions: Seasonal Influenza
Interventions: BIOLOGICAL: inactivated split influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability & PK of KX2-361 in Subjects w Adv. Malignancies Refractory to Conventional Therapies
Status: COMPLETED
Conditions: Advance Malignancies
Interventions: DRUG: KX2-361
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abnormal QT-Response to the Sudden Tachycardia Provoked by Standing in Individuals With Drug-induced Long QT Syndrome
Status: COMPLETED
Conditions: Long QT Syndrome
Interventions: DEVICE: tilt table
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Antibiotic Irrigations for Intra-Abdominal Drains
Status: RECRUITING
Conditions: Abdominal Abscess
Interventions: DRUG: Gentamicin Sulfate Inj 20mg/2ml vial for injection|DRUG: Clindamycin phosphate 6 mg/1ml for injection|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of RG7314 to Investigate Efficacy and Safety in Individuals With Autism Spectrum Disorders (ASD)
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Placebo|DRUG: RG7314
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomised Controlled Trial of the Efficacy of Acupuncture Versus Placebo on the Caesarean Section Rate in Case of Cervical Dystocia in Full-term Pregnancy
Status: TERMINATED
Conditions: Cervical Dystocia
Interventions: DEVICE: Acupuncture|DEVICE: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Study to Characterize the Pharmacokinetics and Safety of TV-45070 Ointment in Healthy Volunteers
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: TV-45070|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Mentoring to be Active for Rural Appalachia Children
Status: RECRUITING
Conditions: Physical Activity|Exercise|Body Composition
Interventions: BEHAVIORAL: Mentoring to be Active plus Family|BEHAVIORAL: Tracking Health and Fitness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Titration Study of a Glucagon-Like Peptide-1 (GLP-1) Analogue in Patients With Type 2 Diabetes Treated With Metformin.
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: Placebo|DRUG: Taspoglutide 20mg|DRUG: Taspoglutide 20mg-30mg|DRUG: Taspoglutide 20mg-40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Multiple Micronutrient Supplementation on Growth, Morbidity, and Mortality of HIV Infected Children in Uganda
Status: COMPLETED
Conditions: HIV Infections
Interventions: DIETARY_SUPPLEMENT: multiple micronutrients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Monoclonal Antibody Therapy in Treating Patients With Refractory Anaplastic Large Cell Lymphoma or Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: monoclonal antibody HeFi-1
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Understand the Real-world Awareness and Perceptions of Systemic inFLAMmation and rolE of hsCRP as a Biomarker in Patients With AtheroSclerotic CardioVascular Disease and Chronic Kidney Disease Among Nephrologists
Status: COMPLETED
Conditions: Atherosclerotic Cardiovascular Disease (ASCVD)|Chronic Kidney Disease (CKD)|Systemic Inflammation
Interventions: OTHER: No treatment given
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p