pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Testing the Addition of the Anti-cancer Viral Therapy Telomelysin™ to Chemoradiation for Patients With Advanced Esophageal Cancer and Are Not Candidates for Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Esophageal Adenocarcinoma|Advanced Gastroesophageal Junction Adenocarcinoma|Clinical Stage II Esophageal Adenocarcinoma AJCC v8|Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8|Clinical Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IIB Esophageal Adenocarcinoma AJCC v8|Clinical Stage IIB Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage III Esophageal Adenocarcinoma AJCC v8|Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage II Esophageal Adenocarcinoma AJCC v8|Pathologic Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IIA Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IIB Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IIB Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage III Esophageal Adenocarcinoma AJCC v8|Pathologic Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IIIA Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage II Esophageal Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage III Esophageal Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IIIA Esophageal Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IIIB Esophageal Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8|Unresectable Gastroesophageal Junction Adenocarcinoma|Squamous Cell Carcinoma|Squamous Cell Cancer
Interventions: DRUG: Carboplatin|DRUG: Paclitaxel|RADIATION: Radiation Therapy|BIOLOGICAL: Telomerase-specific Type 5 Adenovirus OBP-301
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Epidural Analgesia on Burst Suppression
Status: RECRUITING
Conditions: Post-operative Delirium|Cognitive Dysfunction|Electroencephalography
Interventions: DRUG: Bupivacaine-fentanyl|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 2 Study of HEC88473 Injection in Subjects With Type 2 Diabetes Mellitus
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: HEC88473, Placebo, Dulaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Finding Evaluation of Kudzu Root Extract in Women With Menopause Symptoms
Status: COMPLETED
Conditions: Menopause
Interventions: DIETARY_SUPPLEMENT: 3 caps x3/day|DIETARY_SUPPLEMENT: 3 caps x2/day|DIETARY_SUPPLEMENT: 2 caps x3/day|DIETARY_SUPPLEMENT: 2 caps x2/day|DIETARY_SUPPLEMENT: 3 caps x1/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Frailty Rehabilitation
Status: RECRUITING
Conditions: Frailty
Interventions: OTHER: Control|BEHAVIORAL: Group Exercise|COMBINATION_PRODUCT: Nutrition and Medication review|DIETARY_SUPPLEMENT: Protein Supplement|DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety Study of the VEGA UV-A System to Treat Keratoconus
Status: TERMINATED
Conditions: Keratoconus
Interventions: DEVICE: The VEGA UV-A Illumination System|DRUG: Riboflavin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Radiotherapy Plus Temozolomide for Refractory Brain Metastases
Status: COMPLETED
Conditions: Brain Metastases
Interventions: RADIATION: Fractionated Stereotactic Radiotherapy|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SEEG-Guided DBS for OCD
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: PMT Stereoencephalography (SEEG)|DEVICE: Vercise Genus™ Deep Brain Stimulation (DBS) System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesia After Knee Arthroscopy :Dexmedetomidine vs Fentanyl
Status: COMPLETED
Conditions: Analgesia
Interventions: DRUG: Dexmedetomidine|DRUG: Fentanyl|DRUG: Bupivacain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Bevacizumab, Erlotinib, FOLFOX for Patients With Untreated Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Neoplasm Metastasis
Interventions: DRUG: erlotinib|DRUG: FOLFOX|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Mass Balance of [14C]HMPL-523 in Healthy Adult Male Chinese Subjects
Status: COMPLETED
Conditions: Imumune Thrombocytopenia(ITP) Human Mass Balance
Interventions: DRUG: HMPL-523|DRUG: 150 µCi [14C]HMPL-523
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Investigation of the Acute and Chronic Cognitive and Mood Effects of CP9700 in Humans
Status: COMPLETED
Conditions: Cognitive Function|Mood
Interventions: DIETARY_SUPPLEMENT: CP9700|DIETARY_SUPPLEMENT: Matched Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Single Dose Intravesical Apaziquone Postoperative in Patients Undergoing TURBT for Noninvasive Bladder Cancer (SPI-612)
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: Apaziquone|DRUG: Placebo|PROCEDURE: TURBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does the Use of a Genomic Tumor Board Increase the Number of Patients Who Receive Genome-Informed Treatment
Status: RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm|Recurrent Malignant Solid Neoplasm|Refractory Malignant Solid Neoplasm
Interventions: OTHER: Best Practice|OTHER: Chart Abstraction|OTHER: Educational Intervention|PROCEDURE: Genomic Profile|OTHER: Interview|OTHER: Questionnaire Administration|OTHER: Tumor Board Review
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Sonography in Hypotension and Cardiac Arrest in the Emergency Department.
Status: COMPLETED
Conditions: Hypotension|Point of Care Ultrasound|Shock
Interventions: DEVICE: Ultrasound (A point of care ultrasound protocol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Sirolimus Conversions in African-American Renal Transplant Recipients
Status: COMPLETED
Conditions: Absence; Kidney
Interventions: DRUG: rapamune, mycophenolate mofetil and steroid|DRUG: tacrolimus, sirolimus and steroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparing Subsartorial Saphenous Nerve Blocks With and Without Dexamethasone for Anterior Cruciate Ligament Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Reconstruction|Regional Anesthesia, Saphenous Nerve Block
Interventions: DRUG: Bupivacaine Only|DRUG: Bupivacaine with 1 mg of Dexamethasone|DRUG: Bupivacaine with 4 mg of Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pregabalin on the Spinal Anesthesia
Status: COMPLETED
Conditions: Block
Interventions: DRUG: Placebo|DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Treatment of Recurrent Trigeminal Neuralgia by Using Extended Duration of Pulsed Radiofrequency
Status: COMPLETED
Conditions: Trigeminal Neuralgia
Interventions: DEVICE: Pulsed radiofrequency (PRF)|DEVICE: thermocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Home Monitoring in Adults With Cystic Fibrosis (HOMECF)
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: PROCEDURE: Home Monitoring|OTHER: Clinical Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pazopanib/DCE-MRIs in Renal Cell Carcinoma (RCC)
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Pazopanib|DEVICE: DCE-MRI and Quantitative Doppler Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heat Shock Protein (HSP) 70 to Quantify and Characterize Circulating Tumor Cells
Status: UNKNOWN
Conditions: Melanoma Stage IV|Sarcoma|Squamous Cell Carcinoma|Pancreatic Cancer Stage IV|Prostate Cancer|Breast Cancer Stage IV
Interventions: DIAGNOSTIC_TEST: CTC isolation by HSP70
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Tirzepatide (LY3298176) in Adults With Type 2 Diabetes Switching From a GLP-1 RA (SURPASS-SWITCH-2)
Status: COMPLETED
Conditions: Type 2 Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: Tirzepatide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spironolactone Versus Indapamide in Obese and Hypertensive Patients
Status: UNKNOWN
Conditions: Hypertension
Interventions: DRUG: Spironolactone|DRUG: Indapamide|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Upper Extremity Rehabilitation in pwFSHD (Patient With Facioscapulohumeral Dystrophia)
Status: COMPLETED
Conditions: Facioscapulohumeral Muscular Dystrophy
Interventions: OTHER: upper extremity rehabilitation program|DIAGNOSTIC_TEST: Results of assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transcriptional and Epigenetic Program of PCOS Women
Status: ACTIVE_NOT_RECRUITING
Conditions: PCOS
Interventions: OTHER: DEXA|OTHER: Magnetic Resonance (MR) Assessment of the Abdomen|OTHER: MR assessment of Whole Body Fat|PROCEDURE: Adipose tissue biopsy|OTHER: Oral glucose tolerance test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Extracorporeal CO2 Removal in Hypercapnic Patients
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DEVICE: LOW FLOW EXTRACORPOREAL CO2 REMOVAL, PROLUNG ESTOR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Family-based Pulmonary Rehabilitation (PR) on Patients With Chronic Obstructive Pulmonary Disease (COPD) and Their Family Members
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: BEHAVIORAL: Family-based PR program|BEHAVIORAL: Conventional PR program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Deep Neuromuscular Blockade on Requirement of Intravenous Anesthetic Agent
Status: COMPLETED
Conditions: Laparoscopy|General Anesthesia|Neuromuscular Blockade
Interventions: DRUG: Rocuronium: PTC(Post-tetanic count) 1~2|DRUG: Rocuronium: TOF(Train-of-four) 1~2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: "The Voice of Reflux" - Backflow of Gastric Juice Leads to Irritation of the Vocal Folds: Are There Typical Differences in the Voice?
Status: RECRUITING
Conditions: GERD Gastroesophageal Reflux Disease|Laryngopharyngeal Reflux Disease
Interventions: DIAGNOSTIC_TEST: Voice sample; Recording with microphone + Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Tazarotene and Minocycline Therapies for Maintenance of Facial Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Tazarotene 0.1% gel + placebo capsule, Oral minocycline (100 mg capsule) + vehicle gel, Tazarotene 0.1% gel + oral minocycline (100 mg capsule)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Assess Safety, Tolerability and Pharmacokinetics of AntiBKV in Healthy Adult Volunteers.
Status: COMPLETED
Conditions: BK Virus Nephropathy
Interventions: BIOLOGICAL: AntiBKV|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Conventional and Ultrasonic Implant Site Preparation
Status: COMPLETED
Conditions: Bone Atrophy, Alveolar
Interventions: PROCEDURE: ultrasound implant site preparation|PROCEDURE: conventional implant site preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Clindamycin Phosphate Topical Lotion, 1% in Subjects With Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: GDC 268 Lotion|DRUG: Clindamycin Phosphate Lotion 1%|DRUG: GDC Vehicle Lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of the Effects of Aleglitazar and Actos on Renal Function on Patients With Type 2 Diabetes.
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: Actos|DRUG: aleglitazar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ES102 (OX40 Agonist) in Combination With JS001 in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor|Neoplasms|Malignant Tumor
Interventions: DRUG: ES102|DRUG: JS001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BI-1910 as a Single Agent and in Combination With Pembrolizumab for the Treatment of Advanced Solid Tumors
Status: RECRUITING
Conditions: Solid Tumors|Non Small Cell Lung Cancer|Hepatocellular Carcinoma
Interventions: DRUG: BI-1910|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel Versus Intercalated Erlotinib-docetaxel in Patients With Relapsed EGFR Wild Type, ALK Negative Non Squamous Cell Carcinoma
Status: TERMINATED
Conditions: Carcinoma, Non-small Cell Lung
Interventions: DRUG: Docetaxel|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Su Jok Application in After Lumbar Disc Surgery
Status: COMPLETED
Conditions: Pain, Postoperative|Lumbar Disc Herniation|Surgery|Nurse's Role
Interventions: OTHER: Su Jok Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nasal Fentanyl and Buccal Midazolam for Dying Patients
Status: COMPLETED
Conditions: Terminal Cancer
Interventions: DRUG: PecFent and Epistatus|DRUG: Standard subcutaneous medication|DRUG: Epistatus Alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lipotecan Based Concurrent Chemoradiotherapy in Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis
Status: TERMINATED
Conditions: HepatoCellular Carcinoma|Portal Vein Tumor Thrombosis
Interventions: DRUG: Lipotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exposure, D-cycloserine Enhancement, and Functional Magnetic Resonance Imaging (fMRI) in Snake Phobics
Status: COMPLETED
Conditions: Specific Phobia
Interventions: DRUG: D-cycloserine|BEHAVIORAL: Exposure therapy|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Co-Administered AZD9056 (Steady State) and Simvastatin (Single Dose) in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: simvastatin|DRUG: AZD9056 + simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety of Body Composition Analysis in Heart Failure Patients With Implantable Cardioverter Defibrillators (ICDs)
Status: COMPLETED
Conditions: Heart Failure|Obesity
Interventions: DEVICE: Body Composition Analysis InBody Scale
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A 7 Day Adhesive Device Wear Study to Evaluate BD StatLock™ Devices
Status: COMPLETED
Conditions: Peripheral Intravenous Catheter Stabilization
Interventions: DEVICE: StatLock™ Catheter Stabilization Device and the StatLock™ stabilization device accessory (Foam Strip)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multi-center Study to Assess Safety, Tolerability and Efficacy of Topical Pravibismane in Moderate DFI Patients
Status: COMPLETED
Conditions: Diabetic Foot Infection|Diabetic Foot
Interventions: DRUG: Topical Pravibismane|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Anlotinib Combined With Icotinib as the First-line Treatment in Patients With EGFR Concomitant Mutation NSCLC
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Anlotinib|DRUG: Icotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fully Automated Anesthesia, Analgesia and Fluid Management
Status: COMPLETED
Conditions: General Anesthetic Drug Overdose|Adverse Effect of Intravenous Anesthetics, Sequela|Complication of Anesthesia|Drug Delivery System Malfunction|Hemodynamic Instability|Underdosing of Other General Anesthetics
Interventions: OTHER: BIS XP, Covidien, Ireland|OTHER: EV-1000 TM, Edwards Lifesciences, Irvine, California, USA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgery Plus Celiac Nerve Block for Long-term Pancreatic Cancer Pain Control
Status: COMPLETED
Conditions: Pancreas Cancer|Biliary Tract Cancer
Interventions: OTHER: Alcohol Injection|OTHER: Placebo Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of GSK1120212, a MEK Inhibitor, in Subjects With Uveal Melanoma
Status: WITHDRAWN
Conditions: GNA11 Mutation-positive Metastatic Melanoma|GNAQ Mutation-positive Metastatic Melanoma|Cancer|Metastatic Uveal Melanoma
Interventions: DRUG: GSK1120212
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-Leukemia Immune Responses After Irradiation of Extramedullary Tumors
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myeloid Leukemia|Recurrent Acute Myeloid Leukemia
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|OTHER: Electronic Health Record Review|OTHER: Photography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Respiratory Drive Response in COPD Patients During Exercise With Non Invasive Ventilation (NIV).
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: Exercise with spontaneous ventilation.|DEVICE: Exercise with NIV|DEVICE: Exercise with HFNC
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Program for Rifampicin-Resistant Disease With Stratified Medicine for Tuberculosis
Status: NOT_YET_RECRUITING
Conditions: Tuberculosis, Pulmonary|Tuberculosis, Multidrug-Resistant|Tuberculosis, MDR
Interventions: DRUG: Bedaquiline|DRUG: Linezolid|DRUG: Pretomanid|DRUG: Moxifloxacin|DRUG: Control Arm FQ-S MDR/RR-TB regimen, designed according to latest WHO guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sympathetic Mechanisms in the Cardiovascular and Metabolic Alterations of Obesity
Status: SUSPENDED
Conditions: Obesity-Associated Insulin Resistance
Interventions: DRUG: Moxonidine 0.2 MG|DRUG: Amlodipine 5 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multiparametric Telemonitoring In Elderly People With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: PROCEDURE: Telemonitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Parent Infant Skin-to-Skin Contact Intervention Based on The Co-parenting Theory
Status: COMPLETED
Conditions: Postpartum Anxiety|Parturition; Precipitate
Interventions: BEHAVIORAL: Skin to skin contact and co-parenting theory course|BEHAVIORAL: Skin to skin contact instruction manual and co-parenting theory brochure|BEHAVIORAL: Daily face-to-face skin to skin contact guidance during hospitalization|BEHAVIORAL: Online punching skin to skin contact|BEHAVIORAL: Routine obstetric care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Lyon Real World Evidence in Metastatic NeuroEndocrine Tumours
Status: UNKNOWN
Conditions: Gastro-enteropancreatic Neuroendocrine Tumor|Health Care Costs|Metastatic Cancer
Interventions: OTHER: Metastatic gastroenteropancreatic and lung neuroendocrine tumors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Repeatability in Measurements of Two ssOCT and One OLCR Biometer
Status: COMPLETED
Conditions: Cataract Senile
Interventions: DEVICE: biometric measurement IOLMaster 700|DEVICE: biometric measurement Lenstar LS 700|DEVICE: biometric measurement Anterion Heildelberg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Clinical Study to Compare the Efficacy and Safety of AK105 Plus Anlotinib and Capecitabine/Oxaliplatin (CapeOx) , Anlotinib Plus CapeOx, Bevacizumab Plus CapeOx
Status: UNKNOWN
Conditions: Unresectable Metastatic Colorectal Cancer
Interventions: DRUG: AK105 injection|DRUG: Anlotinib hydrochloride capsule|DRUG: CapeOX|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Effects of Euphytose® on Psychological and Physiological Measures of Stress
Status: COMPLETED
Conditions: Mood
Interventions: DRUG: Euphytose®|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Designed SIA Instrument Supported Interpersonal Relations-Based Group Practice on Psychological Well-Being and Creativity
Status: COMPLETED
Conditions: Psychological Stress|Psychology, Positive|Psychological Well-Being
Interventions: BEHAVIORAL: Designed SIA Instrument Supported Interpersonal Relations-Based Group Practice|BEHAVIORAL: Placebo group practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, Pharmacokinetic and Absolute Bioavailability Study of JNJ-63623872 Administered as an Intravenous Infusion and a 600-Milligram (mg) Oral Dose in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-63623872|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Auricular Vagus Nerve Stimulation For Fibromyalgia Syndrome
Status: COMPLETED
Conditions: Fibromyalgia|Myofascial Pain Syndrome
Interventions: DEVICE: Vagus nerve stimulator|OTHER: exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AMBULATE Continued Access Protocol to Evaluate the Cardiva Mid-Bore Venous Vascular Closure System (VVCS)
Status: COMPLETED
Conditions: Surgical Wound
Interventions: DEVICE: Cardiva Mid-Bore Venous Vascular Closure Device (VVCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Zilver PTX Drug-Eluting Stent in the Above-the-Knee Femoropopliteal Artery
Status: COMPLETED
Conditions: Peripheral Vascular Diseases
Interventions: DEVICE: Zilver® PTX™ Drug Eluting Vascular Stent|PROCEDURE: Angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of Y-2(Edaravone And Borneol) Sublingual Tablet
Status: UNKNOWN
Conditions: Stroke, Acute|Intracranial Hemorrhages
Interventions: DRUG: Y-2(Edaravone And Borneol) Sublingual Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Parent-Based Intervention to Reduce Sexual Risk Behavior in Adolescents
Status: COMPLETED
Conditions: Behavior and Behavior Mechanisms
Interventions: BEHAVIORAL: Families Talking Together|BEHAVIORAL: Active Control on Hygiene & Nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Immunogenicity, Safety, and Efficacy of High Capacity Process Etanercept in Rheumatoid Arthritis Subjects
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: BIOLOGICAL: etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ascending Single-Dose and Multiple-Dose Study to Evaluate RJ4287 in Healthy Subjects
Status: RECRUITING
Conditions: Drug Safety
Interventions: DRUG: RJ4287|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Caregiver Pathway - An Intervention to Support Caregivers of Critically Ill Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Caregiver Stress Syndrome
Interventions: BEHAVIORAL: Structured support of caregivers at the ICU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nivolumab and Stereotactic Ablative Radiation Therapy (SAbR) for Metastatic Clear Cell Renal Cell Carcinoma
Status: TERMINATED
Conditions: Metastatic Clear Cell Renal Cell Carcinoma
Interventions: DRUG: Nivolumab|RADIATION: SAbR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis Participants 12 Months of Age and Older
Status: NOT_YET_RECRUITING
Conditions: Cystic Fibrosis
Interventions: DRUG: ELX/TEZ/IVA|DRUG: IVA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Dosimetry of [177Lu]Lu-PSMA-617 in Chinese Adult Male Patients With Progressive PSMA-Positive mCRPC
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Interventions: DRUG: [177Lu]Lu-PSMA-617|OTHER: Best supportive/best standard of care (BS/BSOC)|DRUG: 68Ga-PSMA-11
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin in High Responder Polycystic Ovary Syndrome (PCOS) Patients Undergoing IVF Cycles
Status: COMPLETED
Conditions: Infertility|Polycystic Ovary Syndrome (PCOS)
Interventions: DRUG: Metformin|DRUG: Placebo administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selenium Supplementation in Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Cardiovascular Disease
Interventions: DRUG: Selenium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Sildenafil Citrate During and After Radiotherapy/Hormone Therapy for Erectile Function Versus Radiotherapy/Hormone Therapy for Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer|Erectile Dysfunction
Interventions: DRUG: sildenafil citrate and questionaires|DRUG: placebo tablets and questionaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Effect of N-acetyl Cysteine on the Renal Graft Function Biomarkers (IL18, NGAL)
Status: UNKNOWN
Conditions: Disorder Related to Renal Transplantation
Interventions: DRUG: N-acetyl Cysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Research Study in Patients With Persistent Macular Edema
Status: COMPLETED
Conditions: Diabetes|Macular Edema|Diabetic Retinopathy|Retinal Disease|Uveitis, Posterior
Interventions: DRUG: DEX PS DDS®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Rhu-pGSN for Severe Covid-19 Pneumonia
Status: COMPLETED
Conditions: Sars-CoV2
Interventions: DRUG: Recombinant human plasma gelsolin (Rhu-pGSN)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Efficacy and Safety Between H-CHOP and R-CHOP in Untreated CD20-Positive Diffuse Large B-cell Lymphoma Patients
Status: UNKNOWN
Conditions: Recruiting
Interventions: DRUG: H02+CHOP|DRUG: Rituxan +CHOP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Follow-up Study of Growth, Safety, and Efficacy of an Infant Formula for Healthy Term Infants
Status: COMPLETED
Conditions: Healthy|Term Infants
Interventions: OTHER: Study Formula (SF)|OTHER: Comparator Formula (CF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy Study of Brimonidine/Timolol Fixed Combination in Patients With Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: 0.2% brimonidine/0.5% timolol fixed combination ophthalmic solution|DRUG: Concurrent brimonidine 0.2% and Timolol 0.5% ophthalmic solution|DRUG: Brimonidine 0.2% ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Assessing the Safety and Feasibility of Respiratory Muscle Training and Exercise Training in Children and Adolescents With Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: Inspiratory muscle training (IMT)|BEHAVIORAL: Exercise alone|BEHAVIORAL: IMT and Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Endoscopic Ultrasound (EUS) Guided Ethanol With Paclitaxel Ablation for Pancreatic Mucinous Cystic Neoplasm
Status: TERMINATED
Conditions: Mucinous Cystic Tumor With Moderate Dysplasia|Mucinous Cystadenoma of Pancreas|Mucinous Cystadenocarcinoma of Pancreas|Benign Neoplasm of Pancreas
Interventions: DRUG: Ethanol and Paclitaxel Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Intraocular Melanoma|Melanoma (Skin)
Interventions: BIOLOGICAL: incomplete Freund's adjuvant|BIOLOGICAL: multi-epitope melanoma peptide vaccine|BIOLOGICAL: sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Video Clips Improve Patient Comprehension at the Emergency Department?
Status: COMPLETED
Conditions: Doctor Patient Communication|Patient Safety|New Technologies in Clinical Medicine|Patient Education and Health Literacy|Safe Hospital Discharge
Interventions: OTHER: Videoclips
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Serological Response to SARS-Cov-2 Virus in Personnel of the Institut Bergonié in the Context of the COVID-19 Pandemic
Status: COMPLETED
Conditions: Sars-CoV2|Serum; Disease
Interventions: OTHER: PRO-SERO-COV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Prospective Study Using SupraSDRM® in Promoting Healing and Reducing the Time to Grafting of Full-thickness Wounds
Status: NOT_YET_RECRUITING
Conditions: Surgical Wound|Burns|Trauma Injury
Interventions: DEVICE: SupraSDRM®|DEVICE: NovoSorb® BTM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of GSK961081 in Healthy Volunteer Subjects
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK961081 15mcg SD|DRUG: GSK961081 3mcg SD|DRUG: GSK961081 50mcg SD|DRUG: Placebo SD|DRUG: GSK961081 100mcg SD|DRUG: GSK961081 200mcg SD|DRUG: GSK961081 300mcg SD|DRUG: GSK961081 100mcg RD|DRUG: GSK961081 300mcg RD|DRUG: Placebo RD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Valsartan Versus Placebo on Exercise Tolerance in Patients With Heart Failure
Status: COMPLETED
Conditions: Diastolic Dysfunction, Symptomatic Heart Failure
Interventions: DRUG: valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Fecal Microbiota Transplantation in Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: OTHER: Fecal Microbiota Transplantation Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Pilot Study of Simultaneously Administered Rhu GM-CSF ( CHO Cell ) and Azidothymidine ( AZT ) in Patients With Severe HIV Infection and Leukopenia: Pharmacokinetics and Feasibility
Status: COMPLETED
Conditions: HIV Infections|Cytopenias
Interventions: DRUG: Zidovudine|DRUG: Sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Obicetrapib as an Adjunct to Statin Therapy
Status: COMPLETED
Conditions: Dyslipidemias|High Cholesterol|Hypercholesterolemia
Interventions: DRUG: Obicetrapib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics and Recovery From Gastrointestinal Surgery - 2
Status: UNKNOWN
Conditions: Surgical Recovery
Interventions: DRUG: SuperBio probiotic|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomized, Placebo-controlled, Double-blind Phase 2 Study With OSI-906 in Patients With Advanced HCC
Status: TERMINATED
Conditions: Advanced Hepatocellular Carcinoma (HCC)
Interventions: DRUG: OSI-906|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Immunology Study of a DNA Trivalent Influenza Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Trivalent DNA Vaccine (PIA0601) with or without DEI-LT (pPJV2012)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: The Effect of a Multi-strain Probiotic on Acclimatization to High Altitude
Status: ACTIVE_NOT_RECRUITING
Conditions: Probiotics
Interventions: DIETARY_SUPPLEMENT: SLAB51
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Experiences of Psychotherapeutic Outcomes in Women Victims of Domestic Violence
Status: ACTIVE_NOT_RECRUITING
Conditions: Experiences of Psychitherapeutic Outcomes in Women Victims of Domestic Violence
Interventions: OTHER: Cognitive Behavioral Therapy (Psychotherapeutic Intervention)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: StrataGraft® Skin Tissue in the Promotion of Autologous Skin Regeneration of Complex Skin Defects Due to Thermal Burns That Contain Intact Dermal Elements
Status: COMPLETED
Conditions: Burn, Thermal
Interventions: BIOLOGICAL: StrataGraft Skin Tissue|PROCEDURE: Autograft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing and Testing the Enhancing Active Caregiver Training (EnACT) Intervention for Dementia Family Caregivers
Status: COMPLETED
Conditions: Dementia, Familial
Interventions: BEHAVIORAL: Enhancing Active Caregiver Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Memantine in Assessment of Selected Measures of Volumetric Magnetic Resonance Imaging (MRI) and Cognition in Moderate AD (Alzheimer's Disease)
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: memantine HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Capecitabine and Celecoxib in Patients With Solid Cancers That Have Been Previously Treated With Standard Therapies
Status: TERMINATED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: capecitabine|DRUG: celecoxib|OTHER: pharmacological study|OTHER: laboratory biomarker analysis|OTHER: pharmacogenomic studies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of MRTX1133 in Patients With Advanced Solid Tumors Harboring a KRAS G12D Mutation
Status: RECRUITING
Conditions: Solid Tumor|Advanced Solid Tumor|Non-small Cell Lung Cancer|Colo-rectal Cancer|Pancreatic Adenocarcinoma
Interventions: DRUG: MRTX1133
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in SCLC
Status: RECRUITING
Conditions: Small-cell Lung Cancer|Brain Metastases|SRS|Stereotactic Radiotherapy|Whole Brain Radiotherpay|Hippocampal-avoidance
Interventions: COMBINATION_PRODUCT: Experimental group (SRS/SRT/Hypo-RT)|RADIATION: Controled group (HA-WBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TAVT-45 (Abiraterone Acetate) Granules in Patients With Prostate Cancer
Status: COMPLETED
Conditions: Metastatic Castration-resistant Prostate Cancer|Metastatic Castration-sensitive Prostate Cancer|Metastatic Prostate Cancer
Interventions: DRUG: TAVT-45|DRUG: Zytiga|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin Use in Cardiac Fibrosis in PAI-1 Deficiency
Status: ACTIVE_NOT_RECRUITING
Conditions: Plasminogen Activator Inhibitor-1 Deficiency|Cardiac Fibrosis
Interventions: DRUG: Metformin Extended Release Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: eTMS for Veterans and First Responders With PTSD
Status: RECRUITING
Conditions: Post Traumatic Stress Disorder
Interventions: DEVICE: Electroencephalogram personalized Transcranial Magnetic Stimulation (eTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Registry of Laparoscopic Bariatric Surgery Using Stapling Devices: Observation of Safety and Clinical Efficacy
Status: RECRUITING
Conditions: Obesity|Roux-en-Y Gastric Bypass|Gastrostomy|Nissen Sleeve
Interventions: DEVICE: easyEndoTM Universal Linear Cutting Stapler and reloads (Ezisurg Medical)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Sintilimab Combined With Apatinib and Capecitabine in Advanced Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Sintilimab Combined With Apatinib and Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ONES Grant: CXCL10/CXCR3 Regulation of Ozone-Induced Epithelial Permeability
Status: COMPLETED
Conditions: Environmental and Genetic Factors on Lung Function
Interventions: DRUG: Ozone|OTHER: Filtered Air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Post Marketing Surveillance (PMS) Study to Monitor the Safety of GlaxoSmithKline (GSK) Biologicals' Human Papillomavirus (HPV) Vaccine in Female Chinese Subjects
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia
Interventions: OTHER: Safety data collection (following routine vaccination)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exercise Tolerance in Patients With Implanted Left Ventricular Assist Device
Status: COMPLETED
Conditions: Left Ventricular Assist Device
Interventions: OTHER: Cardiopulmonary exercise tests with maintained baseline optimal pump speed settings.|OTHER: Cardiopulmonary exercise test with gradually increased pump speed depending on live echocardiographic imaging.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study Evaluating CCI-779 in Active Rheumatoid Arthritis on Concomitant Methotrexate Therapy
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: CCI-779|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT