pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pembrolizumab and CXCR4 Antagonist BL-8040 in Treating Patients With Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Metastatic Pancreatic Adenocarcinoma|Recurrent Pancreatic Adenocarcinoma|Stage IV Pancreatic Cancer AJCC v6 and v7
Interventions: DRUG: CXCR4 Antagonist BL-8040|BIOLOGICAL: Pembrolizumab|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Beet Juice Supplementation on Vascular and Inspiratory Muscle Function
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DIETARY_SUPPLEMENT: Nitrate rich beetroot juice|DIETARY_SUPPLEMENT: Nitrate depleted beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Examining the Effects of Mindfulness and Similar Audio-guided Exercises.
Status: COMPLETED
Conditions: Mindfulness|Healthy Population
Interventions: BEHAVIORAL: 20 minutes of mindfulness practice|BEHAVIORAL: 5 minutes of mindfulness practice|OTHER: 5 minute audio book|OTHER: 20 minute audio book|OTHER: 25 minute audio book
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Non-invasive Brain Stimulation on Motor Recuperation
Status: SUSPENDED
Conditions: Stroke
Interventions: DEVICE: tDCS (ELDITH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Volunteers and Patients With Mild Asthma to Investigate the Safety, Anti-inflammatory Effect of Inhaled AZD0449
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: AZD0449|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of EGCG on the Body's Response to Insulin
Status: WITHDRAWN
Conditions: Hypertension|Obesity|Type 2 Diabetes|Insulin Resistance
Interventions: DRUG: EGCG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Base Edited CAR T Cells Against AML: Deep Conditioning Ahead of Allogeneic Stem Cell Transplantation
Status: RECRUITING
Conditions: Relapsed Acute Myeloid Leukaemia
Interventions: BIOLOGICAL: Cryopreserved BE CAR33 T Cells (BE752TBTTBCAR33PBL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics of KBP-5074 in Patients With Moderate Hepatic Impairment
Status: COMPLETED
Conditions: Moderate Hepatic Impairment|Healthy
Interventions: DRUG: KBP-5074
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketogenic Dietary Intervention to Improve Response to Immunotherapy in Patients With Metastatic Melanoma and Metastatic Kidney Cancer
Status: NOT_YET_RECRUITING
Conditions: Clinical Stage IV Cutaneous Melanoma AJCC v8|Metastatic Cutaneous Melanoma|Metastatic Renal Cell Carcinoma|Stage IV Renal Cell Cancer AJCC v8
Interventions: OTHER: Best Practice|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|OTHER: Dietary Intervention|OTHER: Educational Activity|OTHER: Glucose Measurement|OTHER: Ketone Measurement|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pre-operative Immunotherapy Combination Strategies in Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Estrogen Receptor-positive Breast Cancer
Interventions: DRUG: Atezolizumab|DRUG: Cobimetinib|DRUG: Ipatasertib|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neoadjuvant Umbrella Trial for Patients With Unresectable Stage III NSCLC Harboring Rare Mutations.
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer Stage III|Mutation
Interventions: DRUG: Sunvozertinib|DRUG: Crizotinib|DRUG: Pralsetinib|DRUG: Larotrectinib|DRUG: Savolitinib|DRUG: Pyrotinib|DRUG: Dabrafenib+Trametinib|DRUG: Glecirasib|DRUG: Ensartinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-centre Study to Assess the Efficacy and Safety of AZD5423 in COPD Patients on a Background Therapy of Formoterol
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: AZD5423|DRUG: Budesonide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of E/C/F/TAF (Genvoya®) Versus E/C/F/TDF (Stribild®) in HIV-1 Infected, Antiretroviral Treatment-Naive Adults
Status: COMPLETED
Conditions: Acquired Immunodeficiency Syndrome|HIV Infections
Interventions: DRUG: E/C/F/TDF|DRUG: E/C/F/TAF Placebo|DRUG: E/C/F/TAF|DRUG: E/C/F/TDF Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Controlled Clinical Study of NPO-11 in Patients Undergoing Gastric Endoscopy
Status: COMPLETED
Conditions: Patients Undergoing Gastric Endoscopy
Interventions: DRUG: NPO-11|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Incentives for Adherence in Adolescent Asthma
Status: COMPLETED
Conditions: Asthma|Asthma in Children
Interventions: BEHAVIORAL: Incentives|BEHAVIORAL: Medication device monitoring and reminders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase 1/2 Study of the Combination of Pixantrone, Etoposide, Bendamustine and, in CD20 Positive Tumors, Rituximab in Patients With Relapsed Aggressive Non-Hodgkin Lymphomas of B- or T-cell Phenotype - the P[R]EBEN Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Lymphoma
Interventions: DRUG: PREBEN
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-World Evaluation of Eko Murmur Analysis Software in a Point of Care Setting
Status: RECRUITING
Conditions: Murmur, Heart|Innocent Murmurs|Heart Murmurs|Pathologic Murmur
Interventions: DEVICE: Use of Eko CORE electronic stethoscope
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Secondary Hyperparathyroidism in the Uremic Patient
Status: TERMINATED
Conditions: Secondary Hyperparathyroidism|Chronic Kidney Disease|Vitamin D Deficiency
Interventions: DRUG: paricalcitol|DRUG: alfacalcidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of 90Y-hMN14 to Treat Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Colon Cancer|Rectal Cancer|Colorectal Neoplasms|Colorectal Carcinoma|Colorectal Tumor
Interventions: DRUG: hMN14 (labetuzumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identifying Genes That Predict Recurrence in Women With Breast Cancer Treated With Chemotherapy
Status: COMPLETED
Conditions: Breast Cancer|Estrogen Receptor|Her-2|Pgr
Interventions: GENETIC: microarray analysis|GENETIC: protein expression analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator, Olinciguat (IW-1701), in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Olinciguat|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Nutrition for Post-Traumatic Headache
Status: UNKNOWN
Conditions: Post-Traumatic Headache Chronic Without Intractable Headache
Interventions: OTHER: Diet/nutrition intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Community-based Clinical Trial With Microbiota-directed Complementary Foods (MDCFs) Made of Locally Available Food Ingredients for the Management of Children With Primary Moderate Acute Malnutrition
Status: UNKNOWN
Conditions: Microbiota|Complementary Food|Nutrition
Interventions: DIETARY_SUPPLEMENT: Microbiota Directed Complementary Food (MDCF)|DIETARY_SUPPLEMENT: Ready to Use Supplementary Food (RUSF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Microalgae Extract PhaeoSOL Combined With Natural Stimulant on Cognitive Function and Gaming Performance of Video Gamers
Status: COMPLETED
Conditions: Cognitive Function|Video Gamers
Interventions: DIETARY_SUPPLEMENT: Phaeosol low dose|DIETARY_SUPPLEMENT: Phaeosol high dose|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Cisplatin+Pembrolizumab+RT in Vulvar Cancer
Status: RECRUITING
Conditions: Vulvar Cancer|Vulvar Squamous Cell Carcinoma
Interventions: DRUG: Cisplatin|DRUG: Pembrolizumab|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRI Study After Arterial Switch Operation in Patients With Transposition of the Great Arteries
Status: COMPLETED
Conditions: Transposition of Great Vessels|Surgery
Interventions: OTHER: 3 tesla magnetic resonance imaging findings; coronary artery status|OTHER: 3 tesla magnetic resonance imaging findings; ventricular function and morphology
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: IRX-2, Cyclophosphamide, and Pembrolizumab in Treating Participants With Recurrent or Metastatic Gastric or Gastroesophageal Junction Cancer
Status: COMPLETED
Conditions: Clinical Stage IV Gastric Cancer AJCC v8|Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IVA Gastric Cancer AJCC v8|Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IVB Gastric Cancer AJCC v8|Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8|Metastatic Gastric Adenocarcinoma|Metastatic Gastroesophageal Junction Adenocarcinoma|Pathologic Stage IV Gastric Cancer AJCC v8|Pathologic Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IV Gastric Cancer AJCC v8|Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8|Recurrent Gastric Adenocarcinoma|Recurrent Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Cyclophosphamide|BIOLOGICAL: Cytokine-based Biologic Agent IRX-2|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: POLAT-001 Compared to Latanoprost Ophthalmic Solution in Patients With Ocular Hypertension and Open-angle Glaucoma
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: POLAT-001|DRUG: Latanoprost ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evolution of Management Strategies of Heart Failure Patients With Implantable Defibrillators
Status: UNKNOWN
Conditions: Heart Failure|Sudden Cardiac Death|Implantable Defibrillator
Interventions: DEVICE: The Medtronic CareLink system (Minneapolis, MN, USA).
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of New Diagnostic Tool Using Fluorescence to Detect High-grade Vulvar Intraepithelial Neoplasia
Status: RECRUITING
Conditions: Vulvar Intraepithelial Neoplasia|Vulvar High Grade Squamous Intraepithelial Lesion|Differentiated Vulvar Intraepithelial Neoplasia
Interventions: DRUG: Metvixia Topical Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treg, Th17 Cells, NKT in Epithelial Ovarian Tumor
Status: COMPLETED
Conditions: Ovarian Cancer|Borderline Ovarian Tumors|Benign Ovarian Tumor|Unexplained Infertility
Interventions: OTHER: Assessment of percentage of Treg, Th17, NKT and serum level of HE4, CA125 and ROMA.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 2 Neurofeedback Protocols in the Treatment of Attention Deficit Hyperactivity Disorder in Children and Adolescents
Status: RECRUITING
Conditions: ADHD
Interventions: OTHER: SMR (12-15 Hz)|OTHER: alpha band (8 -12Hz)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRISM 2.0 in Diverse Living Contexts
Status: COMPLETED
Conditions: Social Isolation in Older Adults
Interventions: BEHAVIORAL: PRISM 2.0 Condition|BEHAVIORAL: Tablet Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Impact of Indacaterol (Onbrez®) on the Individual Lives and Health Status of Patients With COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Indacaterol (Onbrez®) /QAB149
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Flexible-Dose, Adjunctive Therapy Trial in Adults With Parkinson's Disease With Motor Fluctuations
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Tavapadon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Yield Rate for Procurement the Histologic Core With Endoscopic Ultrasound-guided Fine Needle Biopsy With 20-gauge Ultrasound Biopsy Needles for Solid Pancreatic Masses: Pilot Study
Status: COMPLETED
Conditions: Pancreatic Cancer|Solid Pancreatic and Peripancreatic Lesion
Interventions: DEVICE: 20-gauge ProCore FNB needle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: TMC435350-TiDP16-C101 - A Study to Examine the Safety, Tolerability and Pharmacokinetics of Increasing Oral Doses of TMC435350 After Single and Repeated Dosing
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: TMC435350; Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Kids With Iron Deficiency and Scoliosis
Status: RECRUITING
Conditions: Adolescent Idiopathic Scoliosis|Neuromuscular Scoliosis|Perioperative/Postoperative Complications|Iron Deficiencies|Anemia|Spinal Fusion|Postoperative Cognitive Dysfunction
Interventions: DIETARY_SUPPLEMENT: Oral ferrous sulfate|DIETARY_SUPPLEMENT: Oral placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Simplified Papilla Preservation Flap(SPPF) and Enamel Matrix Derivative(EMD) With or Without Connective Tissue(CTG) Wall for the Treatment of Non Contained Infrabony Defects. A Randomized Controlled Clinical Trail
Status: NOT_YET_RECRUITING
Conditions: Intrabony Periodontal Defect
Interventions: PROCEDURE: Enamel matrix derivative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lateral Pelvic Lymph Node Dissection for Rectal Neuroendocrine Neoplasms Undergoing Laparoscopic Total Mesenteric Excision
Status: RECRUITING
Conditions: Rectal Neuroendocrine Neoplasm
Interventions: PROCEDURE: lateral pelvic lymph node dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-arm Safety Study of Transplantation Using Umbilical Cord Blood and Human Placental-derived Stem Cells From Partially Matched Related Donors in Persons With Certain Malignant Blood Diseases and Non-malignant Disorders
Status: UNKNOWN
Conditions: Hematologic Malignancies
Interventions: PROCEDURE: UCB and HPDSC
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Clinical Performance and Subjective Preference of Three Contact Lenses
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: etafilcon A|DEVICE: methafilcon A - Interozzo|DEVICE: methafilcon A - CVI (CooperVision)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Imaging Lymphatic Function in Normal Subjects and in Persons With Lymphatic Disorders
Status: UNKNOWN
Conditions: Lymphedema|Lymphatic Disorders|Lipedema|Vascular Malformation|Vascular Anomaly|Dercum Disease
Interventions: DRUG: NIRFLI with ICG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess the Efficacy and Safety of Somatostatin in the Treatment of Acute Severe Upper Gastrointestinal Bleeding
Status: COMPLETED
Conditions: Peptic Ulcer
Interventions: DRUG: Somatostatin UCB (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: Combined Antiinflammatory and Angiostatic Therapy in Patients With Hormone-refractory Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: imatinib mesylate|DRUG: Treosulfane|DRUG: etoricoxib|DRUG: pioglitazone|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proximal Junctional Kyphosis Following Long Instrumented Spinal Fusion: The Effect of Implant Selection
Status: WITHDRAWN
Conditions: Kyphosis
Interventions: DEVICE: Less rigid rod|DEVICE: Rigid Rod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy Treatments in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Celecoxib|DRUG: Capecitabine|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lay Health Coaches for Weight Loss: Peers Versus Mentors
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Reduced Intensity Behavioral Weight Loss + Peer Health Coach|BEHAVIORAL: Reduced Intensity Behavioral Weight Loss + Mentor Health Coach|BEHAVIORAL: Reduced Intensity Behavioral Weight Loss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Long-Term Safety and Efficacy of Povorcitinib in Participants With Moderate to Severe Hidradenitis Suppurativa
Status: RECRUITING
Conditions: Hidradenitis Suppurativa (HS)
Interventions: DRUG: Povorcitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of the Basel Phenotyping Cocktail Combination Capsule
Status: COMPLETED
Conditions: CYP450 Phenotyping
Interventions: OTHER: "Basel phenotyping cocktail" capsule|OTHER: "Basel phenotyping cocktail" individual components
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Randomized Multicenter Clinical Study On the High Vacuum Body Cavity Drainage System Following Open Heart Surgery
Status: COMPLETED
Conditions: Coronary Artery Disease|Heart Valve Disease
Interventions: DEVICE: NO-NUMO™ High Vacuum Body Cavity Drainage System|DEVICE: PVC Chest Tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Quantification of the Effect of the OtoBand on Objective Measures of Vertigo and Dizziness
Status: COMPLETED
Conditions: Dizziness|Vertigo|Vestibular Migraine|Vestibular Neuritis|Labyrinthitis
Interventions: DEVICE: Otoband|DEVICE: Placebo Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fish Oils and Soybean Lecithin Supplementation Modulate Immune Function in Runners
Status: COMPLETED
Conditions: Immune Dysfunction
Interventions: DIETARY_SUPPLEMENT: dietary supplementation|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Clinical Trial to Determine the Effects of 40 Mg Doxycycline Versus a Placebo Control for the Treatment of Rosacea
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Losartan in Decompensated Heart Failure
Status: COMPLETED
Conditions: Congestive Heart Failure|Low Cardiac Output
Interventions: DRUG: Losartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Strategies for Vascular Access Closure After Transcatheter Aortic Valve Implantation
Status: COMPLETED
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: Combination of one Perclose ProGlide or ProStyle (Abbott Vascular) and one Angio-Seal (Terumo).|DEVICE: Combination of two ProGlides or ProStyles (Abbott Vascular).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Long Biliopancreatic Limb vs. Long Alimentary Limb in Superobesity, a Randomized Study
Status: COMPLETED
Conditions: Morbid Obesity|Weight Loss
Interventions: PROCEDURE: gastric bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Laser Photocoagulation on the Soft Tissue Healing During Socket Preservation
Status: COMPLETED
Conditions: Soft Tissue Healing
Interventions: PROCEDURE: Socket sealing by diode laser photocoagulation|PROCEDURE: socket sealing with dense polytetrafluroethylene membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Single Dose of Amisulpride on Functional Brain Changes
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Amisulpride Pill|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of High-oleic Canola and Flaxseed Oils for Hypercholesterolemia and Cardiovascular Disease Risk Factors
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: High-Oleic Canola Oil|DIETARY_SUPPLEMENT: High-Oleic Canola/Flaxseed Oil Blend|DIETARY_SUPPLEMENT: Western Dietary Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Feasibility Study of Short Term Fondaparinux (Arixtra) in Chemotherapy-Pretreated Ovarian Carcinoma Patients at High Risk of Progression
Status: WITHDRAWN
Conditions: Ovarian Carcinoma
Interventions: DRUG: Fondaparinux
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Marketing Safety Study in Japan of Shock and Anaphylaxis After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA-1273 COVID-19 Vaccine in Persons in at High Risk of Severe COVID-19
Status: COMPLETED
Conditions: SARS-CoV-2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy Study of a Child-centered Version of the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in Children
Status: RECRUITING
Conditions: Emotional Disorders|Childhood Anxiety|Childhood Depression
Interventions: BEHAVIORAL: Arm 1: Transdiagnostic intervention|BEHAVIORAL: Arm 2: Anxiety-focused intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Neoadjuvant Chemoimmunotherapy and Immuno-consolidationafter Compared With Immunoconsolidation After Radical Chemoradiotherapy for Stage III Potentially Resectable NSCLC
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Adebrelimab|RADIATION: radical chemoradiotherapy|DRUG: Platinum based chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Exercise and Markers of Medial Temporal Health in Youth At-risk for Psychosis
Status: COMPLETED
Conditions: Attenuated Psychosis Syndrome
Interventions: BEHAVIORAL: Exercise 1|BEHAVIORAL: Exercise 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of RYGB on Alpha- and Beta Cell Function and Sensitivity to Incretins in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type2 Diabetes|Obesity, Morbid
Interventions: DIAGNOSTIC_TEST: Oral Glucose Tolerance Test|DIAGNOSTIC_TEST: Hyperglycemic clamp with infusion of saline, GLP-1 or GIP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Contribution of an Off-the-shelf Carbon Ankle Foot Orthosis (AFO) in the Management of Walking Functional Impairment
Status: UNKNOWN
Conditions: Neuropathy (Disorder)
Interventions: DEVICE: Phase A1|DEVICE: Phase B1|DEVICE: Phase A2|DEVICE: Phase B2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Effects of BOTOX on Weight Loss and Glucose Tolerance in Obese, Type 2 Diabetic Subjects
Status: TERMINATED
Conditions: Obese|Diabetes Mellitus, Type 2
Interventions: DRUG: Botox 200 UNT Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparisonof Extended Myoectomy and Myoectomy by Morrow in Patients With Hypertrophic Obstructive Cardiomyopathy (HOCM)
Status: UNKNOWN
Conditions: Hypertrophic Obstructive Cardiomyopathy
Interventions: PROCEDURE: extended myectomy|PROCEDURE: myectomy by Morrow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Dose Study to Investigate the Safety and Pharmacokinetics of XC101-D13H in Healthy Adult Subjects
Status: UNKNOWN
Conditions: Migraine
Interventions: DRUG: XC101-D13H|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combining Resting Blood Flow Restriction With Neuromuscular Electrical Stimulation: Effects on Blood Lactate Levels and Lower Limb Muscle Function
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DEVICE: Blood Flow Restriction|DEVICE: Neuromuscular Electrical Stimulation|BEHAVIORAL: Squat exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treating Co-Morbid Sleep Difficulties in Veterans With Posttraumatic Stress Disorder (PTSD): A Pilot Study
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder|Insomnia
Interventions: BEHAVIORAL: Sleep Intervention for PTSD (SIP).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-world Effectiveness of Ustekinumab in Participants Suffering From Inflammatory Bowel Disease (Crohn's Disease or Ulcerative Colitis) With Extra-intestinal Manifestations or Immune-mediated Inflammatory Diseases
Status: COMPLETED
Conditions: Crohn Disease|Colitis, Ulcerative
Interventions: DRUG: Ustekinumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cultures Before and After Decolonization in Community Dwelling Adults With Current S. Aureus Colonization
Status: COMPLETED
Conditions: Human Microbiome
Interventions: DRUG: Mupirocin calcium ointment, 2%|DRUG: Topical Chlorhexidine, 4%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: DC-CIK Immunotherapy Plus Chemotherapy vs Chemotherapy Alone in the Adjuvant Treatment of Stage III Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: Fluorouracil|DRUG: Oxaliplatin|DRUG: Leucovorin|BIOLOGICAL: DC-CIK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Continuous Pulse Oximetry Monitoring and Early Intervention Using Wearable Device on the Incidence of Postoperative Hypoxemia
Status: UNKNOWN
Conditions: Postoperative Respiratory Complication
Interventions: DEVICE: Low flow oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: INEC Study: Immuno-modulating Enteral Nutrition in Cancer
Status: COMPLETED
Conditions: Malnutrition|Esophageal Cancer|Head and Neck Cancer
Interventions: DIETARY_SUPPLEMENT: Impact (R) Enteral Nutrition|OTHER: impact
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Decoding Presymptomatic White Matter Changes in Huntington Disease
Status: COMPLETED
Conditions: Huntington Disease|White Matter Alterations
Interventions: OTHER: Brain imaging|OTHER: Neurological assessments|BEHAVIORAL: Psychological assessments|BEHAVIORAL: Behavioural assessments
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Age and Prior Immunity to Response to Seasonal Influenza Vaccines in Children
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Live attenuated Influenza vaccine|BIOLOGICAL: Trivalent Influenza Vaccine|BIOLOGICAL: TIV followed by LAIV|BIOLOGICAL: LAIV followed by TIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lymphedema Prevention After Lymph Node Emptying
Status: COMPLETED
Conditions: Lymphedema|Breast Cancer|Prevention|Rehabilitation
Interventions: BEHAVIORAL: Exercices|BEHAVIORAL: Informative talk|DEVICE: Compression garment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With Ketamine
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DRUG: Ketamine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of AXOS on the Colon Metabolism in Healthy Volunteers
Status: COMPLETED
Conditions: Gut Health
Interventions: DIETARY_SUPPLEMENT: Arabinoxylanoligosaccharides|DIETARY_SUPPLEMENT: Maltodextrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Pulse Pressure During Tilttable and Erigo® in Adult Patients With Acquired Brain Injury
Status: COMPLETED
Conditions: Brain Injuries|Hypotension, Orthostatic|Syncope
Interventions: DEVICE: Erigo® Hocoma|DEVICE: Traditional tilt table from Rehab-Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prochlorperazine Maleate Versus Placebo for the Prophylaxis of Acute Mountain Sickness
Status: RECRUITING
Conditions: Acute Mountain Sickness
Interventions: DRUG: Prochlorperazine Maleate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Perioperative Pregabalin Use, Rehabilitation, Pain Outcomes and Anxiety Following Hip Surgery
Status: UNKNOWN
Conditions: Anxiety
Interventions: DRUG: Pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Artificial Tears on Radioiodine Levels in the Nasolacrimal Duct System
Status: TERMINATED
Conditions: Thyroid Carcinoma|Radioactive Iodine Level
Interventions: DRUG: Artificial Tears
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Randomized Controlled Trial of a Nurse Delivered Stage-matched Smoking Cessation Intervention to Promote Heart Health of Cardiac Patients
Status: COMPLETED
Conditions: Smoking Cessation|Smoking
Interventions: BEHAVIORAL: nurse-delivered stage-matched smoking cessation counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart Failure
Status: RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction|Obesity|Weight Loss|Chronic Heart Failure
Interventions: DRUG: Semaglutide Injectable Product|DIETARY_SUPPLEMENT: Calorie-restricted diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fruquintinib-based Treatment for Refractory Bone and Soft Tissue Sarcomas After Several Lines of TKIs' Resistance
Status: COMPLETED
Conditions: Bone Sarcoma|Soft Tissue Sarcoma|Refractory Tumor
Interventions: DRUG: Fruquintinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Laser InGaAlP (660Nm) to Prevent Radiodermatitis in Breast Cancer Patients Submitted to Radiation Therapy
Status: COMPLETED
Conditions: Radiotherapy; Adverse Effect, Dermatitis or Eczema|Breast Neoplasms
Interventions: DEVICE: Laser therapy|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intravenous rhMBL in Patients With Multiple Myeloma Receiving Chemotherapy Followed by Stem Cell Transplant
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Intravenous Recombinant Human Mannose-Binding Lectin (rhMBL)|DRUG: Intravenous Recombinant Human Mannose-Binding Lectin (rhMBL)|DRUG: Intravenous Recombinant Human Mannose-Binding Lectin (rhMBL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Cosmetic Outcomes of Straight Line and W-plasty Techniques for Linear Wound Closure
Status: COMPLETED
Conditions: Suture Dermatologic|Surgery|Cosmetic Outcome
Interventions: PROCEDURE: W-plasty/Linear closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Phase I Open-Label, Dose Escalation Study To Determine The Maximum Tolerated Dose And To Evaluate The Safety Profile Of Lenalidomide (Revlimid®, CC-5013) With Pemetrexed In Subjects With Advanced Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: CC-5013|DRUG: pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrophysiological Effects of a Single 10 μg Dose of Exenatide on the 12-Lead Electrocardiogram QT Interval in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: exenatide|DRUG: Moxifloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Iron Absorption From Complementary Food Fortificants (CFFs) and Acceptability of CFFs by Beninese Children
Status: COMPLETED
Conditions: Iron Deficiency|Anemia
Interventions: OTHER: NaFeEDTA|OTHER: Phytase|OTHER: Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Evaluation of Biofinity Multifocal Compared With Air Optix Aqua Multifocal and With PureVision Multifocal
Status: COMPLETED
Conditions: Presbyopia
Interventions: DEVICE: BIOFINITY® MF - AIR OPTIX® AQUA MF|DEVICE: BIOFINITY® MF - PUREVISION® MF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Dapansutrile Plus Pembrolizumab in Patients With PD-1 Refractory Advanced Melanoma
Status: RECRUITING
Conditions: Melanoma
Interventions: DRUG: Dapansutrile|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conducting Outreach to Improve Cervical Cancer Screening Rates Among Underscreened Patients
Status: COMPLETED
Conditions: Uterine Cervical Neoplasms
Interventions: OTHER: Letter and informational sheet|OTHER: Email|OTHER: Phone|OTHER: Multimodal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effects of Digital Stories Intervention on Psychosocial Well-being
Status: COMPLETED
Conditions: Bone Marrow Transplant|Information Disclosure|Hematopoietic Stem Cell Transplantation|Psychosocial Health|Depression|Anxiety|Stress|Narrative
Interventions: BEHAVIORAL: Baseline Surveys|BEHAVIORAL: Digital Stories Intervention|BEHAVIORAL: Information Control Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Telbivudine in Patients With Chronic Hepatitis B
Status: WITHDRAWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: telbivudine|DRUG: adefovir dipivoxil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of the Effects of EpiCor on Digestive Comfort
Status: COMPLETED
Conditions: Constipation|Gastrointestinal Discomfort
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: EpiCor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Pilate Versus Aerobic Exercises on Dyspnea , Functional Capacity and Anxiety Status in Patients With COPD
Status: RECRUITING
Conditions: COPD Patients
Interventions: OTHER: Pilates Exercises|OTHER: Aerobic Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock
Status: COMPLETED
Conditions: Septic Shock
Interventions: DRUG: recombinant human insulin|DRUG: hydrocortisone|DRUG: fludrocortisone|DRUG: Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is Levosimendan Superior to Milrinone Regarding Acute Kidney Injury After Cardiac Surgery for Congenital Heart Disease?
Status: COMPLETED
Conditions: Congenital Heart Defects
Interventions: DRUG: Levosimendan|DRUG: Milrinone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: BioPoly RS Knee Registry Study for Cartilage Defect Replacement
Status: COMPLETED
Conditions: Cartilage Injury|Defect of Articular Cartilage|Cartilage Damage
Interventions: DEVICE: BioPoly RS Partial Resurfacing Knee Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability of Zanubrutinib Tablets Compared to Capsules and Effects of Food on the Pharmacokinetics of the Tablet in Healthy Adults
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Zanubrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Aromatherapy Application on Pain, Stress and Behaviors of The Newborn
Status: COMPLETED
Conditions: Newborn, Infant, Disease
Interventions: OTHER: Lavender application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect Of Ketamine Infusion In Patients With COPD Applied One Lung Ventilation
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease Mild|Chronic Obstructive Pulmonary Disease Moderate|Chronic Obstructive Pulmonary Disease Severe|Lungcancer|Anesthesia
Interventions: DRUG: Ketamine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Resistance Training and Injection Treatment for Chronic Achilles Tendinopathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Achilles Tendinopathy
Interventions: OTHER: Homebased resistance training|OTHER: Supervised heavy slow resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Neurocysticercosis Treatment
Status: COMPLETED
Conditions: Neurocysticercosis
Interventions: DRUG: albendazole|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risk of Air Contamination During Visceral Surgery in COVID19 Patients
Status: UNKNOWN
Conditions: Sars-CoV2|Surgery|COVID
Interventions: OTHER: Cartography of air contamination, environment contamination and biological fluid by Sars-Cov2 during visceral surgery in COVID19 patients.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial of Gemcitabine and Cisplatin in Patients With Inoperable Biliary Tract Carcinomas
Status: COMPLETED
Conditions: Biliary Tract Carcinoma
Interventions: DRUG: gemcitabine|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risedronate and Parathyroid Hormone to Reverse Osteoporosis Caused by Chronic Steroid Use
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Risedronate|DRUG: Parathyroid Hormone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Evaluate Early Bactericidal Activity, Safety, Tolerability, and Pharmacokinetics of Multiple Oral Doses of Telacebec (Q203)
Status: COMPLETED
Conditions: Treatment-naïve, Sputum Smear-positive Patients With Drug-sensitive Pulmonary TB
Interventions: DRUG: Telacebec (Q203)|DRUG: Rifafour e-275
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Impact of Exercise Based Intensive Interdisciplinary Pain Treatment (IIPT) on Endogenous Pain Modulation in Youth With Chronic Pain Syndromes
Status: COMPLETED
Conditions: Chronic Pain Syndrome|Fibromyalgia|Chronic Headache Disorder|Functional Abdominal Pain Syndrome|Complex Regional Pain Syndromes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p