pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Tacrolimus Versus Clobetasol Propionate in the Treatment of Vulvar Lichen Sclerosus
Status: COMPLETED
Conditions: Vulvar Lichen Sclerosus
Interventions: DRUG: Tacrolimus cream|DRUG: Clobetasol cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Trial on Immunochemotherapy Plus Autologous Stem Cell Transplantation (SCT) and Allogenic SCT in Primary Mantle-Cell-Lymphoma
Status: UNKNOWN
Conditions: Mantle-Cell Lymphoma
Interventions: DRUG: Immunochemotherapy|DRUG: High-dose BEAM plus autologous SCT|OTHER: HLA-identical allogenic SCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Oral Clindamycin and Pyrimethamine for the Treatment of Toxoplasmic Encephalitis in Patients With AIDS
Status: COMPLETED
Conditions: Toxoplasmosis, Cerebral|HIV Infections
Interventions: DRUG: Pyrimethamine|DRUG: Leucovorin calcium|DRUG: Clindamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Timing of Umbilical Cord Occlusion in Premature Babies( <33 w). Delayed vs Early.
Status: UNKNOWN
Conditions: Delayed Umbilical Cord Clamping Benefits|Postpartum Haemorrhage|Intraventricular Haemorrhage
Interventions: PROCEDURE: delayed umbilical cord occlusion|PROCEDURE: early umbilical cord occlusion|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Evaluating Study of Odelepran for the Use in Patient With Alcohol Dependence
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: Odelepan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Maintenance Ketamine Infusions for Treatment-Resistant Bipolar Depression
Status: RECRUITING
Conditions: Bipolar Disorder|Bipolar Depression|Bipolar I Disorder|Bipolar II Disorder
Interventions: DRUG: Ketamine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on the Effect of Vemurafenib on the Pharmacokinetics of a Single Dose of Tizanidine in Patients With BRAFV600 Mutation-Positive Metastatic Malignancies
Status: COMPLETED
Conditions: Malignant Melanoma, Neoplasms
Interventions: DRUG: Tizanidine|DRUG: Vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Two Different Non-pharmacologic Methods for Painandfear Relief During Blood Specimen Collection Inchildren
Status: UNKNOWN
Conditions: Pain
Interventions: DEVICE: Buzzy|OTHER: DistrACTION® Cards
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Validation/Interventional Study on Stress Index in Predicting Mechanical Stress in ARDS Patients
Status: UNKNOWN
Conditions: Respiratory Distress Syndrome, Adult
Interventions: PROCEDURE: Change ventilatory parameters with stress index monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of ProliFerative Vitreoretinopathy With Intravitreal MethotreXate in Primary Retinal DEtachment Repair (FIXER) Trial
Status: RECRUITING
Conditions: Proliferative Vitreoretinopathy|Rhegmatogenous Retinal Detachment
Interventions: DRUG: Methotrexate Injection|DRUG: Methotrexate Infusion|DRUG: Sham Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Prosocial Online Support Group for Distressed Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: BEHAVIORAL: prosocial online support group|BEHAVIORAL: Standard Online Support Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Povidone-iodine Versus Saline in Vaginal Cleansing Before Office Hysteroscopy
Status: COMPLETED
Conditions: Postoperative Infection
Interventions: DRUG: povidone-iodine|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Lipid Management in Renal Transplant Recipients Using Evolocumab.
Status: RECRUITING
Conditions: Hyperlipidemias
Interventions: DRUG: Evolocumab|DRUG: Statins (Cardiovascular Agents)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of LM-101 Injection in Patients With Advanced Malignant Tumors
Status: SUSPENDED
Conditions: Malignant Tumors
Interventions: DRUG: LM101|DRUG: Toripalimab|DRUG: Rituximab|DRUG: Envafolimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Outcomes of a Criterion-based Rehabilitation Protocol for ACL Reconstruction in Amateur Athlete
Status: COMPLETED
Conditions: Knee Ligament Injury|Anterior Cruciate Ligament Injuries
Interventions: OTHER: rehabilitation protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Aliskiren/Amlodipine/Hydrochlorothiazide in Patients With Moderate-severe Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Aliskiren|DRUG: Amlodipine|DRUG: Hydrochlorothiazide (HCTZ)|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Kinetic Chain Training on the Treatment Outcome of Overhead Athletes With Impingement
Status: COMPLETED
Conditions: Shoulder Impingement Syndrome
Interventions: OTHER: Traditional training|OTHER: Separate kinetic chain training|OTHER: Integrated kinetic chain training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preliminary Exploration of Applying Multi-person Simulation Training to Improve Nurse-led Burn and Scald Nursing Care
Status: COMPLETED
Conditions: Virtual Reality|High Fidelity Simulation Training
Interventions: OTHER: Multi-person virtual reality simulation scenario training|OTHER: Multi-person high-fidelity simulation scenario training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Dreamer Girls Project: Adaptation of SISTA/SIHLE for HIV/AIDS and Substance Abuse Prevention Among Black Adolescent Girls
Status: NOT_YET_RECRUITING
Conditions: HIV/AIDS
Interventions: OTHER: Theater/Pilot Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Trial Evaluating the Efficacy of Local Budesonide Therapy in the Management of Hyposmia in COVID-19 Patients Without Signs of Severity
Status: COMPLETED
Conditions: Budesonide|Olfaction Disorders|SARS-CoV-2|Anosmia
Interventions: DRUG: Budesonide Nasal|OTHER: Physiological serum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Avelumab in First-line NSCLC (JAVELIN Lung 100)
Status: COMPLETED
Conditions: First Line Non-Small Cell Lung Cancer
Interventions: DRUG: Avelumab|DRUG: Pemetrexed|DRUG: Paclitaxel|DRUG: Gemcitabine|DRUG: Gemcitabine|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Avelumab Weekly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Trial to Evaluate Efficacy and Accuracy of a Portable Ultrasound Scanner for Non-Invasive Bladder Volume Measurement (BladderScan BVI3000) in Patients After Radical Cystectomy and Bladder Reconstruction
Status: UNKNOWN
Conditions: Bladder Substitution|Reconstructed Bladder
Interventions: OTHER: BladderScan BVI 3000
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Medtronic Terminate AF Study
Status: RECRUITING
Conditions: Persistent Atrial Fibrillation|Longstanding Persistent Atrial Fibrillation
Interventions: PROCEDURE: Surgical Ablation|DEVICE: Cardioblate and Cryoflex hand held devices
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ipamorelin for Management of Post-Operative Ileus
Status: COMPLETED
Conditions: Ileus
Interventions: DRUG: Ipamorelin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Lenvatinib in Children and Adolescents With Refractory or Relapsed Solid Malignancies and Young Adults With Osteosarcoma
Status: COMPLETED
Conditions: Tumors|Solid Malignant Tumors|Osteosarcoma|Differentiated Thyroid Cancer (DTC)
Interventions: DRUG: Lenvatinib|DRUG: Lenvatinib|DRUG: Lenvatinib|DRUG: Lenvatinib|DRUG: Lenvatinib|DRUG: Ifosfamide|DRUG: Etoposide|DRUG: Ifosfamide|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lymphoscintigraphy Directed Elective Neck Radiation for p16+ Favorable Risk Oropharynx Cancer
Status: RECRUITING
Conditions: Oropharynx Cancer
Interventions: RADIATION: Radiation therapy (5 days for 7 weeks)|RADIATION: Radiation therapy (5 days for 6 weeks)|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Innovative Food Structures to Enhance Nutrient Bioavailability
Status: COMPLETED
Conditions: Vitamin D Deficiency|Aging Well
Interventions: DIETARY_SUPPLEMENT: Vitamin D enriched (20 mcg/day) olive oil emulsion drink|DIETARY_SUPPLEMENT: Vitamin D enriched (20 mcg/day) coconut oil emulsion drink|DIETARY_SUPPLEMENT: Placebo coconut oil emulsion drink|DIETARY_SUPPLEMENT: Vitamin D supplement (20 mcg/day)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Nutrition Intervention in Drug Naive HIV-infected Kenyan Women and Their Children
Status: COMPLETED
Conditions: HIV Infections
Interventions: DIETARY_SUPPLEMENT: Meat Biscuit|DIETARY_SUPPLEMENT: Soy Biscuit|DIETARY_SUPPLEMENT: Wheat Biscuit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The PLUS Study: Comparison of VicrylPlus® Versus Vicryl® for Repair of Perineal Tears
Status: COMPLETED
Conditions: Skin Structures and Soft Tissue Infections|Wound Infection
Interventions: DEVICE: VicrylPlus®|DEVICE: Vicryl®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: TREg Activation in the Treatment of the PELADE (Alopecia Areata)
Status: COMPLETED
Conditions: Alopecia Areata
Interventions: DRUG: IL2|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging Advanced NSCLC Patients Undergoing PD-1/PD-L1 Directed Therapy Using [18F]-FARAG
Status: NOT_YET_RECRUITING
Conditions: Advanced Non Small Cell Lung Cancer
Interventions: DRUG: [18F]F-AraG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intraoperative NIRS of Transplanted Kidney for Prediction of Acute and Sub-acute Injury
Status: UNKNOWN
Conditions: Graft Failure
Interventions: DEVICE: Invos Model 5100C Cerebral/Somatic Oximeter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Role of Immune Responses After Acute Myocardial Infarction
Status: UNKNOWN
Conditions: Myocardial Fibrosis
Interventions: DRUG: Rosuvastatin plus clopidogrel|DRUG: Rosuvastatin plus ticagrelor|DRUG: Simvastatin plus clopidogrel|DRUG: Simvastatin plus ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Radiosurgery or Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases That Have Been Removed By Surgery
Status: COMPLETED
Conditions: Cognitive/Functional Effects|Metastatic Cancer|Neurotoxicity|Radiation Toxicity|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: RADIATION: stereotactic radiosurgery|RADIATION: whole-brain radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sex Differences, Hormones & Smoking Cessation
Status: COMPLETED
Conditions: Tobacco Cessation
Interventions: OTHER: Placebo|DRUG: Progesterone|OTHER: Smoking Cessation Behavioral Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing the Adaptation of Commercial Milk and A2 Milk in Lactose Maldigesters
Status: RECRUITING
Conditions: Lactose Intolerance
Interventions: OTHER: Milk containing A1 and A2 beta-casein|OTHER: Milk containing only A2 beta-casein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II Study of Carfilzomib, Pomalidomide, and Dexamethasone for Myeloma Patients Who Had Relapsed or Progressed After Carfilzomib, Lenalidomide, and Dexamethasone
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Carfilzomib 56 MG [Kyprolis]|DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Pharmacokinetic Properties of Oral OKN-007 in Patients With Recurrent High-Grade Glioma
Status: RECRUITING
Conditions: High-grade Glioma|Oligodendroglioma|Astrocytoma|Glioblastoma Multiforme
Interventions: DRUG: Low-dose OKN-007, BID|DRUG: Low-dose OKN-007, TID|DRUG: Mid-dose OKN-007, TID|DRUG: High-dose OKN-007, TID
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-Invasive Ventilation Versus Continuous Positive Airway Pressure in Cardiogenic Pulmonary Edema: a Multicentre Study
Status: COMPLETED
Conditions: Cardiogenic Pulmonary Edema
Interventions: DEVICE: continuous positive airway pressure|DEVICE: noninvasive pressure support ventilation|DEVICE: noninvasive pressure support ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Safety and Efficacy of an Implantable Neural Acquisitor & Stimulator System in Patients With Motor Disability
Status: NOT_YET_RECRUITING
Conditions: Tetraplegia
Interventions: DEVICE: NEO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Vortioxetine Versus Other Antidepressants With Pregabalin Augmentation in Burning Mouth Syndrome
Status: RECRUITING
Conditions: Burning Mouth Syndrome
Interventions: DRUG: Vortioxetine 20Mg Tab|DRUG: Paroxetine 20 Mg Oral Tablet|DRUG: Sertraline 50 MG|DRUG: Citalopram 20mg|DRUG: Escitalopram 10mg|DRUG: Duloxetine 60 MG|DRUG: Pregabalin 75mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Neutrophil CD64 and Monocyte HLA-DR Markers in the Dignosis of Neonatal Sepsis
Status: NOT_YET_RECRUITING
Conditions: Neonatal Sepsis
Interventions: DIAGNOSTIC_TEST: CD64 , HLA-DR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: [18F]FPIA PET/CT Imaging in Patients With Solid Tumours
Status: RECRUITING
Conditions: Cancer|Tumor, Solid
Interventions: DRUG: [18F]Fluoropivalate ([18F]Fluoro-2,2-Dimethylpropionic Acid)|PROCEDURE: PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Spontaneous Reproductive Outcomes After Oral Inositol Supplementation in Infertile Polycystic Ovarian Syndrome Women.
Status: NOT_YET_RECRUITING
Conditions: Polycystic Ovarian Syndrome|Infertility, Female
Interventions: DIETARY_SUPPLEMENT: Inositol + Folic acid|DIETARY_SUPPLEMENT: Folic acid|BEHAVIORAL: Regular intercourses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Standard Therapy With or Without Dalteparin in Treating Patients With Advanced Breast, Lung, Colorectal, or Prostate Cancer
Status: COMPLETED
Conditions: Breast Cancer|Colorectal Cancer|Lung Cancer|Prostate Cancer|Veno-occlusive Disease
Interventions: DRUG: dalteparin|DRUG: standard therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Immune Response of Two-Doses of Candidate Influenza Vaccine GSK 1557484A in Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Pumarix™|BIOLOGICAL: Pandemrix ™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Determining the Effect of Vitamin D, Dyslipidemia and Microvascular in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Vitamin D3|DRUG: Routine treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of SSGJ-705 Monotherapy in Patients With Advanced Malignant Tumors
Status: RECRUITING
Conditions: Locally Advanced, Recurrent or Metastatic Malignancies
Interventions: DRUG: SSGJ-705
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation Effects on Pain Perception
Status: COMPLETED
Conditions: Gastric Bypass Surgery Pain Management
Interventions: DEVICE: Real TMS 45 min|DEVICE: Sham TMS 45 min|DEVICE: Real TMS 4 Hours|DEVICE: Sham TMS 4 Hours
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Non-invasive, Wearable Multi-parameter System for the Early Prediction of Cognitive Decline and Dementia in Older Adults
Status: UNKNOWN
Conditions: Mild Cognitive Impairment|Healthy Aging
Interventions: OTHER: Cognitive-motor training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Photopheresis in GvHD After Hematopoietic Transplantation: Characteristics of the Procedure and of the Cell Product
Status: ENROLLING_BY_INVITATION
Conditions: Graft Vs Host Disease|Extracorporeal Photopheresis
Interventions: PROCEDURE: Extracorporeal Photopheresis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Retinal Fundus Camera Evaluation
Status: COMPLETED
Conditions: Normal Healthy Subjects With no Known Ocular Diseases
Interventions: DEVICE: Topcon TRC-NW400|DEVICE: TRC-NW8|DEVICE: TRC-NW400|DEVICE: Canon-CR2|DEVICE: Zeiss Visucam PRO
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Stimulating Compassion UsingTranscutaneous Vagus Nerve Stimulation
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DEVICE: Active transcutaneous vagus nerve stimulation|BEHAVIORAL: Active self-compassion imagery|DEVICE: Sham transcutaneous vagus nerve stimulation|BEHAVIORAL: Sham mental imagery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Research Study to Investigate the Effect of NNC0174-0833 on a Birth Control Pill in Women Who Are Not Able to Become Pregnant
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: DRUG: NNC0174-0833|DRUG: Oral contraceptive (OC) tablets|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sacral Neuromodulation for Neurogenic LUT Dysfunction
Status: COMPLETED
Conditions: Refractory Neurogenic LUTD
Interventions: DEVICE: Turning OFF the neuromodulator|DEVICE: Turning ON the neuromodulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Combination of 177Lu-TLX250 and Peposertib in Patients With Carbonic Anhydrase IX -Expressing Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor, Adult|Advanced Solid Tumor|Advanced Renal Cell Carcinoma
Interventions: DIAGNOSTIC_TEST: 89Zr-TLX250|COMBINATION_PRODUCT: 177Lu-TLX250 and Peposertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rosiglitazone Adjunctive Therapy for Severe Malaria in Children
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Rosiglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Two Administration Pathways for Adenosine During Microvascular Function Assessment
Status: NOT_YET_RECRUITING
Conditions: Microvascular Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: microvascular function assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of 3D Michigan Appliance
Status: ENROLLING_BY_INVITATION
Conditions: Myofacial Pain Syndromes
Interventions: DEVICE: 3D printed mitchigen appliance|DEVICE: side chair appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sonography Guided Transcervical Ablation of Uterine Fibroids
Status: COMPLETED
Conditions: Menorrhagia
Interventions: DEVICE: Intrauterine Ultrasound-Guided Radiofreq. Ablation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subarachnoid or Infiltration for Hemorrhoidectomy
Status: COMPLETED
Conditions: Hemorrhoid
Interventions: PROCEDURE: Infiltration|PROCEDURE: Spinal block|DRUG: Bupivacaine|DRUG: 10 mg of hyperbaric 0.5% bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Anesthesia for Closed PKP vs Retrobulbar Anesthesia for Open-sky PKP
Status: UNKNOWN
Conditions: Corneal Opacity|Keratitis, Herpetic|Corneal Ulcer|Corneal Dystrophies, Hereditary
Interventions: PROCEDURE: closed PKP under topical anesthesia|PROCEDURE: open-sky PKP under retrobulbar anesthesia|DRUG: Anti-Rejection Agents|DRUG: Anti-Inflammatory Agents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trial of a Falciparum Malaria Protein (FMP012), E. Coli-expressed PfCelTOS, in Healthy Malaria-Naive Adults
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: Group 1: 10 ug FMP012 with 2 ug GLA-SE|BIOLOGICAL: Group 2: 10 ug FMP012 with 5 ug GLA-SE|BIOLOGICAL: 50 ug FMP012 with 5 ug GLA-SE or 2 ug GLA-SE|OTHER: Controlled group-Challenged Only: no vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Video Games Therapy on Balance and Cognitive Functions in Mild to Moderate Impaired Multiple Sclerosis Patients.
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DEVICE: Video game therapy|DEVICE: Balance platform therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility
Status: COMPLETED
Conditions: Female Infertility|Female Infertility Due to Ovulatory Disorder|Premature Ovarian Failure|Polycystic Ovary Syndrome|Female Infertility of Tubal Origin|Ectopic Pregnancy|Salpingitis|Female Infertility Due to Tubal Block|Female Infertility Due to Tubal Occlusion|Hydrosalpinx|Female Infertility - Cervical/Vaginal|Female Infertility Endocrine|Endometriosis|Fibroids|Congenital Uterine Anomaly|Infections Uterine|Female Infertility of Other Origin
Interventions: DRUG: Human Chorionic Gonadotropin (hCG)|DRUG: Gonadotropins|DRUG: GNRH-A Triptorelin|DRUG: GnRH antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Compare Pharmacokinetic Characteristics of Eperisone and Aceclofenac With NVP-1203
Status: WITHDRAWN
Conditions: Healthy
Interventions: DRUG: NVP-1203|DRUG: Eperisone SR tab. + and Airtal tab.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of Training Programs for Nursing Competency Reinforcement to Spread Trauma Intervention
Status: COMPLETED
Conditions: Nurses Who Work at the Community Mental Health Welfare Center
Interventions: OTHER: Nursing Competency Enhancement Training Program in PTSD Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Short Term Statin Treatment and Endothelial Dysfunction Due to Ischemia and Reperfusion Injury
Status: COMPLETED
Conditions: Ischemia Reperfusion Injury|Endothelial Dysfunction
Interventions: DRUG: rosuvastatin|DRUG: atorvastatin 3 days|DRUG: placebo|DRUG: rosuvastatin 7 days|DRUG: atorvastatin 7 days|DRUG: placebo 7 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Abraxane in Combination With Carboplatin, Erbitux and IMRT for Locally Advanced Squamous Cancer of the Head and Neck
Status: TERMINATED
Conditions: Squamous Cell Carcinoma of the Head and Neck|Basaloid Squamous Cell Carcinoma|Undifferentiated Carcinoma|Adenosquamous Cell Carcinoma
Interventions: DRUG: Abraxane|DRUG: Erbitux|DRUG: Carboplatin|RADIATION: Intensity Modulated Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Avastin/Radiation (XRT)/Temozolomide (Temodar) Followed by Avastin/Temodar/Topotecan for Glioblastoma
Status: COMPLETED
Conditions: Malignant Glioma|Glioblastoma|Gliosarcoma
Interventions: DRUG: Bevacizumab|DRUG: Temozolomide|RADIATION: Radiation Therapy (XRT)|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Food on the Pharmacokinetics of Single Oral Dose Administration of a Fixed-Dose Combination of SYR-322 and Metformin Hydrochloride in Healthy Adult Male Subjects
Status: COMPLETED
Conditions: Clinical Pharmacology
Interventions: DRUG: SYR-322-MET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of 177-Lu-DOTA 0, Tyr 3 Octreotate
Status: COMPLETED
Conditions: Neuroendocrine Tumors
Interventions: RADIATION: [177Lu] DOTA-TATE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment With Rosuvastatin Versus Switching PI (Protease Inhibitor) in Patients HIV With High Cholesterol Levels
Status: COMPLETED
Conditions: HIV|Hypercholesterolaemia
Interventions: DRUG: Switch ritonavir-boosted PI|DRUG: Continue Ritonavir-boosted PI+Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Bridging Anticoagulation for Surgery (The BRIDGE Study)
Status: COMPLETED
Conditions: Arterial Thromboembolic Events|Atrial Fibrillation
Interventions: DRUG: Placebo|DRUG: Dalteparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MR-linac Guided Ultra-hypofractionated RT for Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer|Radiotherapy Side Effect|Magnetic Resonance-linac|Stereotactic Ablative RT|Adaptive Radiotherapy|Localised Disease|Oligometastatic Disease
Interventions: DEVICE: MR-linac
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Leukocyte- and Platelet-Rich Fibrin Membranes in Endoscopic Endonasal Skull Base Reconstruction
Status: UNKNOWN
Conditions: Cranial Sutures; Closure
Interventions: PROCEDURE: Dural closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Levetiracetam as add-on Treatment of Myoclonic Jerks in Adolescents + Adults
Status: COMPLETED
Conditions: Generalized Convulsive Epilepsy
Interventions: DRUG: Levetiracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Ph 2 Study of Glofitamab Alone or in Combination With Polatuzumab Vedotin or Atezolizumab in Richter's Transformation
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Richter's Transformation
Interventions: DRUG: Glofitamab|DRUG: Obinutuzumab|DRUG: Polatuzumab Vedotin|DRUG: Atezolizumab|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of AMG 386 (20060439) in Combination With Cisplatin & Capecitabine in Subjects With Metastatic Gastric, Gastroesophageal Junction, or Distal Esophageal Adenocarcinoma
Status: COMPLETED
Conditions: Gastrointestinal Cancer
Interventions: DRUG: AMG 386 placebo|DRUG: AMG 386 10mg/kg|DRUG: AMG 386 3mg/kg|DRUG: Cisplatin|DRUG: Capecitabine|DRUG: Cisplatin|DRUG: Capecitabine|DRUG: Cisplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety Study of LY03003 in Patients With Early-stage Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: LY03003|DRUG: Neupro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Modifying Virtual Reality Analgesia With Low-Dose Pain Medication
Status: UNKNOWN
Conditions: Virtual Reality Therapy
Interventions: DRUG: Low-dose pain medication (Ketalar) and saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vitamin D Supplementation and Clinical Outcomes in Severe COVID-19 Patients
Status: UNKNOWN
Conditions: Covid-19|Respiratory Distress Syndrome|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Individual Nurse-led Counselling Programme for Patients Early Discharged After Myocardial Infarction.
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Disease|Myocardial Infarction
Interventions: BEHAVIORAL: Nurse-led counselling programme|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Durvalumab (MEDI4736) and TREmelimumab in NEOadjuvant Bladder Cancer Patients (DUTRENEO)
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: Durvalumab|DRUG: Tremelimumab|DRUG: Cisplatin-based neoadjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clopidogrel Use and Long-term Safety After Drug-Eluting Stents Implantation
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Aspirin|DRUG: Aspirin,Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Demonstrate Bioequivalence Between Two Insulin Degludec/Liraglutide Formulations, B5 and V2 in Healthy Subjects
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2|Healthy
Interventions: DRUG: insulin degludec/liraglutide|DRUG: insulin degludec/liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing a 25G EUS Fine Needle Aspiration (FNA) Device With a 20G EUS
Status: COMPLETED
Conditions: Pancreatic Masses|Lymph Nodes
Interventions: DEVICE: 25G FNA needle|DEVICE: 20G ProCore FNB needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Brain Breaks on Educational Achievement in Laboratory Settings: The Break4Brain Project
Status: ACTIVE_NOT_RECRUITING
Conditions: ADHD
Interventions: BEHAVIORAL: Physical activity with engaging cognitively|BEHAVIORAL: Physical activity without engaging cognitively
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Inhaled Corticosteroids in the Systemic Inflammation Induced by Exercise in Patients With COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Fluticasone|DRUG: Inhaled Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Home Mechanical Ventilation in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Hypercapnic Response
Status: WITHDRAWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Home mechanical ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gabapentin as Preanesthetic Medication to Fast Procedures in Pediatric´s Oncology
Status: COMPLETED
Conditions: Pain, Postoperative|Agitation States as Acute Reaction to Exceptional Stress|Anesthesia|Vomiting
Interventions: DRUG: Placebo Group|DRUG: GABA 15mg/kg Group|DRUG: GABA 30mg/kg Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IPI Biochemotherapy for Chemonaive Patients With Metastatic Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: Ipilimumab|DRUG: Temozolomide|DRUG: Cisplatin|DRUG: Interferon Alfa-2b|DRUG: Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Silver Diamine Fluoride After Minimal Caries Removal Technique in Asymptomatic Young Permanent Teeth With Deep Caries
Status: UNKNOWN
Conditions: Deep Caries
Interventions: DRUG: Silver Diamine Fluoride|DRUG: Glass Ionomer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Empowered With Movement to Prevent Obesity and Weight Regain
Status: COMPLETED
Conditions: Obesity|Weight Loss|Sedentary Lifestyle
Interventions: BEHAVIORAL: Weight loss|BEHAVIORAL: Exercise|BEHAVIORAL: Sitless
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Rosiglitazone Therapy In The Prevention Of Coronary Artery Disease In Patients With Impaired Glucose Tolerance
Status: UNKNOWN
Conditions: Impaired Glucose Tolerance
Interventions: DRUG: Rosiglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 ACUTE
Status: ACTIVE_NOT_RECRUITING
Conditions: Covid19
Interventions: DRUG: theraputic heparin|DRUG: prophylactic heparin|DRUG: P2Y12|DRUG: Crizanlizumab Injection|DRUG: SGLT2 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of Mometasone Furoate/Formoterol (MF/F), Montelukast and Beclomethasone Dipropionate (BDP) on Plasma Cortisol Levels of Children 5-11 Years Old With Persistent Asthma (P05574)
Status: WITHDRAWN
Conditions: Asthma
Interventions: DRUG: MF/F Metered Dose Inhaler (MDI) 25/5 mcg|DRUG: MF/F MDI 50/5 mcg|DRUG: MF/F MDI 100/5 mcg|DRUG: BDP hydrofluoroalkane (HFA) 80 mcg|DRUG: Montelukast tablets 5 mg (4 mg for children 5 years of age)|DRUG: Rescue medication: short-acting beta-2 agonist (SABA) MDI|DRUG: Rescue medication: Prednisone/Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Glioblastoma|Recurrent Cholangiocarcinoma|Recurrent Glioma|Recurrent Malignant Solid Neoplasm|WHO Grade 2 Glioma|WHO Grade 3 Glioma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of RO7617991 in Patients With Locally Advanced or Metastatic MAGE-A4-Positive Solid Tumors
Status: WITHDRAWN
Conditions: Refractory Cancer|Recurrent Cancer|Solid Tumor, Adult
Interventions: DRUG: RO7617991|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Factors Affecting Decisions About Breast Reconstruction After Mastectomy in Black and Latina Women
Status: COMPLETED
Conditions: Breast Cancer|Psychosocial Effects of Cancer and Its Treatment
Interventions: OTHER: counseling intervention|OTHER: study of socioeconomic and demographic variables|PROCEDURE: management of therapy complications|PROCEDURE: psychosocial assessment and care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Losmapimod in Subjects With Facioscapulohumeral Muscular Dystrophy (FSHD)
Status: COMPLETED
Conditions: Facioscapulohumeral Muscular Dystrophy (FSHD)
Interventions: DRUG: Losmapimod oral tablet|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Cannabidiol and ∆-9-THC in Humans
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cannabidiol|DRUG: Delta-9-THC|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Role of Metformin and Colesevelam in Human GLP-1 Secretion
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Colesevelam|DRUG: Metformin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Restore CLINICAL TRIAL
Status: UNKNOWN
Conditions: Cervical Radiculopathy|Degenerative Disc Disease
Interventions: DEVICE: M6-C Artificial Cervical Disc|DEVICE: Anterior plate system with corticocancellous allograft bone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Insulin Detemir in Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin detemir|DRUG: insulin NPH|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Anti-PD1 in HCC
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|HCC|Liver Cancer
Interventions: DRUG: Nivolumab|PROCEDURE: Hepatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib Plus CHOP Every 2 Weeks for Advanced Stage DLBCL
Status: COMPLETED
Conditions: Lymphoma, Large-Cell, Diffuse|Lymphoma, B-Cell
Interventions: DRUG: Bortezomib|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisolone|DRUG: Lenograstim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of a New Transepithelial Photorefractive Keratectomy Treatment
Status: COMPLETED
Conditions: Ametropia
Interventions: PROCEDURE: Transepithelial Photorefractive keratectomy (tPRK) without laser polishing|PROCEDURE: Transepithelial Photorefractive keratectomy (tPRK) with laser polishing|PROCEDURE: Standard Photorefractive keratectomy (PRK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Taping & Exercise Therapy on Lower Back Musculoskeletal Conditions in Pakistani Patients
Status: COMPLETED
Conditions: Lower Back Pain|Musculoskeletal Diseases or Conditions
Interventions: PROCEDURE: Therapy|PROCEDURE: Taping technique|PROCEDURE: Therapy with taping|PROCEDURE: SHAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Plant Polar Lipids on Glucose Tolerance
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Polar lipid 1|DIETARY_SUPPLEMENT: Polar lipid 2|DIETARY_SUPPLEMENT: Non-polar lipids|OTHER: No lipids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Postoperative Sore Throat After Lumbar Spine Surgery in the Prone Position
Status: UNKNOWN
Conditions: Post Operative Sore Throat
Interventions: DRUG: dexmedetomidine infusion|DRUG: remifentanil infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: S9031-S9333-S0112-S0301-A Biomarkers Associated With Response to Cytarabine in Samples From Older Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: GENETIC: gene expression analysis|GENETIC: proteomic profiling|OTHER: flow cytometry|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Saquinavir Soft Gelatin Capsules Combined With Other Anti-HIV Drugs in HIV-1 Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Ritonavir|DRUG: Nelfinavir mesylate|DRUG: Saquinavir|DRUG: Stavudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Bioequivalence and Food Effect Study in Healthy Volunteers
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders
Interventions: DRUG: Formulation A|DRUG: Formulation B|DRUG: Formulation C|DRUG: Formulation D|DRUG: Formulation E|DRUG: Formulation F|DRUG: Formulation G
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT