pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Chiropractic and Neuromuscular Reeducation as a Treatment for Autism Symptoms
Status: TERMINATED
Conditions: Autism
Interventions: PROCEDURE: Spinal Manipulative Therapy (SMT)|PROCEDURE: SMT and Neuromuscular Reeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study To Characterize The Safety, Tolerability, PK And PK Of Repeat Doses Of PF-06648671 In Healthy Adults And Healthy Elderly Subjects
Status: COMPLETED
Conditions: Healthy Adult Subjects and Healthy Elderly Subjects
Interventions: DRUG: PF-06648671|DRUG: Midazolam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Controlled Trial to Evaluate the Impact of ZYN Nicotine Pouch Products on Cigarette Usage and BoExp in Adult Smokers Over a 12-week Period
Status: COMPLETED
Conditions: Tobacco Use
Interventions: OTHER: cigarette smoking|OTHER: tobacco flavored and unflavored pouch|OTHER: unrestricted flavor options pouch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Extension Study of MYL-1701P-3001 for Safety and Efficacy
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: BIOLOGICAL: MYL-1701P, a proposed biosimilar to Eylea
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the in Vivo Expression of MU Opioid Receptors Using PET and the Selective Tracer [C-11] Carfentanil in Normal Weight and Obese Subjects
Status: COMPLETED
Conditions: Nuclear Medicine
Interventions: DIAGNOSTIC_TEST: PET for the analysis of mu opioid receptor expression.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: R-wave Optimisation in Cardiac Resynchronisation Therapy Study
Status: COMPLETED
Conditions: Heart Failure, Systolic
Interventions: OTHER: Optimisation of V-V timing using R wave on surface ECG|OTHER: Standard V-V timing settings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Efficacy and Safety of HLX07 Combination Therapy in Patients With Extensive Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Small-cell Lung Cancer
Interventions: DRUG: HLX07|DRUG: HLX10|DRUG: carboplatin and etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Atezolizumab Versus Placebo in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Participants With Newly-Diagnosed Stage III or Stage IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Neoplasms
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Atezolizumab|DRUG: Bevacizumab|DRUG: Atezolizumab Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cost-effectiveness Study of Beclomethasone Versus Ciclesonide as Controller Medications in Pediatric Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Beclomethasone|DRUG: Ciclesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Title: Comparative Effectiveness of Asthma Interventions Within an AHRQ PBRN
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: electronic medical record|OTHER: Integrated Approach to Care|OTHER: usual care|OTHER: Shared Decision Making|OTHER: school based care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An Open-Label Extension Study to Evaluate the Long-Term Safety and Efficacy of Once Daily Mexiletine PR in Patients With Myotonic Dystrophy Type 1 and Type 2 Who Have Completed MEX-DM-302 Study.
Status: NOT_YET_RECRUITING
Conditions: Myotonic Dystrophy
Interventions: DRUG: Mexiletine granules for prolonged-release oral suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Tobacco Dependence Treatment in the Emergency Department
Status: COMPLETED
Conditions: Tobacco Use Disorder
Interventions: BEHAVIORAL: Brief Negotiated Interview (BNI)|DRUG: Nicotine replacement therapy (NRT)|OTHER: CT Smokers Quitline (QL)|OTHER: SmokefreeText (Text)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gabapentin Versus Transdermal Fentanyl Matrix for Chronic Neuropathic Pain
Status: COMPLETED
Conditions: Neuropathic Pain|Spinal Stenosis
Interventions: DRUG: transdermal fentanyl matrix, gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Myotomy for the Treatment of Achalasia (Motility Disorder) of the Esophagus - POEM Procedure
Status: COMPLETED
Conditions: Achalasia
Interventions: PROCEDURE: Endoscopic Esophageal Myotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of the Cost Effectiveness of IV Acetaminophen in Bariatric Surgery
Status: COMPLETED
Conditions: Hospital Costs|Length of Stay|Postoperative Pain Score|Patient Satisfaction
Interventions: DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: VAccination to Improve Clinical outComes in Heart Failure Trial: a Feasibility Study (VACC-HeFT)
Status: COMPLETED
Conditions: Chronic Heart Failure
Interventions: BIOLOGICAL: Influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose Range Finding Study of MK-0941 in Patients With Type 2 Diabetes Mellitus on Insulin (MK-0941-007 AM3 EXT1 AM1)(TERMINATED)
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: MK-0941|DRUG: Comparator: Placebo|BIOLOGICAL: Lantus|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-Transplant 5-Azacitidine In Patients With High-Risk Myelodysplastic Syndrome Who Are Candidates For Allogeneic Hematopoietic Cell Transplant
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: 5-azacitidine|PROCEDURE: Allogeneic Hematopoietic Cell Transplantation (HCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Cetuximab, Capecitabine, and Oxaliplatin With or Without Bevacizumab
Status: TERMINATED
Conditions: Colorectal Neoplasms
Interventions: DRUG: bevacizumab|DRUG: cetuximab|DRUG: Oxaliplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: I-CARE: A Pilot Study of Cognitive Behavioural Therapy(CBT) for Mood and Anxiety Disorders
Status: NOT_YET_RECRUITING
Conditions: Mood Disorders|Anxiety Disorders
Interventions: BEHAVIORAL: CBT-MyOWL|BEHAVIORAL: CBT-as-usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-FCH PET/MRI to Assess Tumor Response in Castration Resistant Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: OTHER: [F-18]-FCH|RADIATION: PET scan|RADIATION: MRI scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: MINIject in Patients With Open Angle Glaucoma Using Single Operator Delivery Tool
Status: COMPLETED
Conditions: Glaucoma, Open-Angle|Glaucoma Eye
Interventions: DEVICE: MINIject CS627 implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors
Status: RECRUITING
Conditions: Advanced Biliary Tract Carcinoma|Advanced Colorectal Carcinoma|Advanced Gastroesophageal Junction Adenocarcinoma|Advanced Lung Adenocarcinoma|Advanced Malignant Solid Neoplasm|Advanced Ovarian Carcinoma|Advanced Pancreatic Carcinoma|Advanced Urothelial Carcinoma|Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8|Metastatic Biliary Tract Carcinoma|Metastatic Colorectal Carcinoma|Metastatic Gastroesophageal Junction Adenocarcinoma|Metastatic Lung Adenocarcinoma|Metastatic Ovarian Carcinoma|Metastatic Pancreatic Carcinoma|Metastatic Urothelial Carcinoma|Refractory Biliary Tract Carcinoma|Refractory Colorectal Carcinoma|Refractory Gastroesophageal Junction Adenocarcinoma|Refractory Lung Adenocarcinoma|Refractory Ovarian Carcinoma|Refractory Pancreatic Carcinoma|Refractory Urothelial Carcinoma|Stage II Pancreatic Cancer AJCC v8|Stage III Colorectal Cancer AJCC v8|Stage III Lung Cancer AJCC v8|Stage III Ovarian Cancer AJCC v8|Stage III Pancreatic Cancer AJCC v8|Stage IV Colorectal Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IV Ovarian Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Devimistat|DRUG: Fluorouracil|DRUG: Gemcitabine Hydrochloride|DRUG: Hydroxychloroquine|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inspiratory Muscle Training for Breathless Patients With Chronic Obstructive Pulmonary Disease and Heart Failure
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive|Heart Failure, Systolic
Interventions: DEVICE: POWERbreathe®KHA (IMT group)|DEVICE: POWERbreathe®KH2 (sham group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-marketing Observational Study to Evaluate the Incremental Impact of AbbVie's Patient Support Program on Patient Reported Outcomes and Health Resource Utilization in Inflammatory Arthritis, Psoriasis and Inflammatory Bowel Diseases in Hungary (VALUE)
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Ankylosing Spondylitis|Psoriatic Arthritis|Psoriasis|Crohn's Disease|Ulcerative Colitis
Interventions: BIOLOGICAL: Adalimumab|BEHAVIORAL: AbbVie Care 2.0
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Integrating Mindfulness Into the Patient-Centered Medical Home (Phase 2)
Status: COMPLETED
Conditions: Depression|Anxiety|Stress Related Disorder|Adjustment Disorders
Interventions: BEHAVIORAL: Mindfulness Training for Primary Care|BEHAVIORAL: 60-minute Introduction to Mindfulness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Assessing the Efficacy and Safety of Treatment With Alpelisib Plus Fulvestrant in Japanese Men and Postmenopausal Women With Advanced Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Breast Cancer
Interventions: DRUG: Alpelisib|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes of High Power Application in Catheter Ablation of Paroxysmal Atrial Fibrillation Guided by Unipolar Signal Modification.
Status: UNKNOWN
Conditions: Atrial Fibrillation Paroxysmal
Interventions: PROCEDURE: high power application|PROCEDURE: Standard power application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pragmatic Randomized Controlled Trial of Therapeutic Anticoagulation Versus Standard Care as a Rapid Response to (SARS-CoV-2) COVID-19 Pandemic
Status: COMPLETED
Conditions: COVID|Coronavirus Infection|Severe Acute Respiratory Syndrome|Thromboembolism, Venous|Anticoagulants and Bleeding Disorders
Interventions: DRUG: Therapeutic anticoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sphenopalatine Ganglion Block and Cold Induced Headaches
Status: NOT_YET_RECRUITING
Conditions: Cold Induced Headache|Brain Freeze|Cold Induced Cephalgia|Headache
Interventions: DRUG: Lidocaine Topical 4% Topical Solution|DRUG: Bitrex|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mapping the Health Status of the Population of French Polynesia: the MATAEA Project
Status: COMPLETED
Conditions: Non Communicable Diseases|Microbiome|Communicable Diseases|Pesticide Exposure|Metal Poison|Genetics Population|Ciguatera
Interventions: OTHER: Questionnaire|OTHER: Physical measurements|OTHER: Biological samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 2 Diabetes Currently Treated With Basal Insulin
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Insulin Efsitora Alfa|DRUG: Insulin Degludec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telehealth Stretching Exercise Program for Women With Fibromyalgia During the Covid-19 Pandemic
Status: UNKNOWN
Conditions: Fibromyalgia|Fibromyalgia, Primary
Interventions: OTHER: Experimental: Active care group|OTHER: Active Comparator: Self-care group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metformin as Maintenance Therapy in Patients With Bone Sarcoma and High Risk of Relapse
Status: RECRUITING
Conditions: Osteosarcoma|Ewing Sarcoma
Interventions: DRUG: Metformin Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A New Agent GM-CT-01 in Combination With 5-FU, Avastin and Leucovorin in Subjects With Colorectal Cancer
Status: WITHDRAWN
Conditions: Colorectal Cancer
Interventions: DRUG: GM-CT-01|DRUG: 5-Fluorouracil, Leukovorin, bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Capecitabine and Radiation Therapy in Treating Patients With Locally Advanced Cervical Cancer or Other Pelvic Cancer
Status: WITHDRAWN
Conditions: Cervical Cancer|Endometrial Cancer|Ovarian Cancer|Vaginal Cancer
Interventions: DRUG: capecitabine|RADIATION: brachytherapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intelligent Hypertension Intervention Study
Status: RECRUITING
Conditions: To Explore Whether the Application of Intelligent Hypertension Management System Can Effectively Reduce Blood Pressure in Hypertensive Patients
Interventions: DEVICE: Intelligent Hypertension Management System|OTHER: The standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In Vivo nCLE Study in the Pancreas With Endosonography of Cystic Tumors
Status: COMPLETED
Conditions: Pancreatic Cysts
Interventions: DEVICE: Cellvizio needle-based Confocal Laser Endomicroscopy (nCLE) system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Postoperative Analgesic Efficacy of Pericapsular Nerve Group Block (PENG) Block for Knee Arthroscopy
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: PROCEDURE: PENG Block combinated with PCA|PROCEDURE: PCA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Safety and Immunogenicity Trial of COVID-19 Vaccine COVIVAC
Status: COMPLETED
Conditions: COVID-19 Disease|SARS Pneumonia|Pneumonia, Viral|COVID-19 Vaccine
Interventions: BIOLOGICAL: COVIVAC|BIOLOGICAL: Phosphate-buffered saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Comparing Single Versus Double Umbilical Cord Blood Transplantation in the Young With Acute Leukemia Remission
Status: UNKNOWN
Conditions: Leukemia
Interventions: PROCEDURE: Transplantation of unrelated cord blood unit(s)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety and Efficacy of ERB-041 on Reduction of Symptoms Associated With Endometriosis in Reproductive-Aged Women
Status: COMPLETED
Conditions: Dysmenorrhea|Dyspareunia|Endometriosis|Pelvic Pain
Interventions: DRUG: ERB-041
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Telmisartan Plus Hydrochlorothiazide in Subjects With Mild-to-moderate Hypertension Who Failed to Respond to Telmisartan Monotherapy
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan + hydrochlorothiazide|DRUG: Telmisartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Prospective Interventional Clinical Trial of an MRI Based Patient Specific Focal Knee Resurfacing Implant
Status: ACTIVE_NOT_RECRUITING
Conditions: Focal Cartilage Lesions
Interventions: OTHER: Follow-up of Episealer implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Early Development of Academic Skills in the Classroom
Status: NOT_YET_RECRUITING
Conditions: General Population of Children Aged 3 to 5 Years Old
Interventions: BEHAVIORAL: JAPI|BEHAVIORAL: Painting group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transcutaneous Vagus Nerve Stimulation (tVNS) for Borderline Personality Disorder (tVNS-BPD)
Status: RECRUITING
Conditions: Borderline Personality Disorder
Interventions: DEVICE: Transcutaneous vagus nerve stimulation (tVNS)|DEVICE: Sham transcutaneous vagus nerve stimulation (Sham tVNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Fosaprepitant for the Prevention of Chemotherapy-induced Nausea and Vomiting in Pediatric Patients
Status: COMPLETED
Conditions: Pediatric Cancer
Interventions: DRUG: Fosaprepitant,ondansetron, dexamethasone|DRUG: placebo ondansetron with dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Low-intensity Laser Therapy in the Treatment of Chronic Musculoskeletal Pain
Status: NOT_YET_RECRUITING
Conditions: Pain, Chronic
Interventions: DEVICE: Low intensity laser treatment|DRUG: Non-steroidal drug (Celecoxib) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a First-in-Human Mosquito Saliva Peptide Vaccine
Status: COMPLETED
Conditions: Mosquito-Borne Disease
Interventions: BIOLOGICAL: AGS-v|BIOLOGICAL: AGS-v + adjuvant|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: NFC Dressing for Skin Graft Donor Sites
Status: COMPLETED
Conditions: Skin Transplantation
Interventions: DEVICE: FibDex wound dressing|DEVICE: NFC wound dressing Types 1-3|DEVICE: Suprathel (comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Efficacy and Safety of a Single Injection of Corifollitropin Alfa (Organon 36286) for Ovarian Stimulation Using Daily Recombinant Follicle Stimulating Hormone (FSH) as Reference (P05787)
Status: COMPLETED
Conditions: In Vitro Fertilization
Interventions: DRUG: Corifollitropin alfa|BIOLOGICAL: RecFSH / Follitropin beta (Days 1 to 7)|DRUG: Placebo Corifollitropin alfa|DRUG: Placebo RecFSH / follitropin beta|BIOLOGICAL: RecFSH / Follitropin beta (Days 8 to hCG)|DRUG: Ganirelix|BIOLOGICAL: hCG|BIOLOGICAL: Progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The POST-ACS Study
Status: RECRUITING
Conditions: Diabetes Mellitus|Acute Coronary Syndrome|Coronary Artery Disease
Interventions: RADIATION: A computerized tomography (CT) coronary angiogram|PROCEDURE: Vicorder (Skidmore medical, UK)|OTHER: Blood tests for inflammation and oxidative stress markers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Cetuximab and Radiation Vs Surgery Before or After Radiation in Patients With Colorectal Carcinoma
Status: WITHDRAWN
Conditions: Colorectal Carcinoma
Interventions: OTHER: Cetuximab and Radiation Therapy|PROCEDURE: Surgery and Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brentuximab Vedotin (SGN-35) as Salvage Treatment for CD30-positive Germ Cell Tumors
Status: COMPLETED
Conditions: Germ Cell Cancer
Interventions: DRUG: Brentuximab Vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Prolonged GnRh Agonists on Results of Intracytoplasmic Sperm Injection (ICSI ) in Endometrioma Patients
Status: COMPLETED
Conditions: Endometrioma
Interventions: PROCEDURE: endometrioma aspiration|DRUG: GnRh agonist ( Decapeptyl )|PROCEDURE: standard long stimulation protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Vestibular Neurectomy Versus Tenotomy of the Stapedius and Tensor Tympani Muscles in the Management of Patients With Unilateral Meniere's Disease
Status: UNKNOWN
Conditions: Ménière
Interventions: PROCEDURE: Surgical treatment|PROCEDURE: Surgical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of INCB050465 in Combination With Ruxolitinib in Subjects With Myelofibrosis
Status: TERMINATED
Conditions: MPN (Myeloproliferative Neoplasms)
Interventions: DRUG: Parsaclisib|DRUG: Parsaclisib|DRUG: Ruxolitinib|DRUG: Parsaclisib|DRUG: Parsaclisib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Single Paravertebral Blockade Injection for Herniorrhaphy in Children
Status: UNKNOWN
Conditions: Reduce Pain After Herniorrhaphy
Interventions: OTHER: Anesthesia induction|OTHER: PVB injection at L1-L2|OTHER: PVB injections at T12-L1, L1-L2 and L2-L3.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Neurobehavioral Effects of Prenatal Mindfulness Training on Maternal Presence and Compassionate Love
Status: RECRUITING
Conditions: Maternal-Fetal Relations|Mother-Child Relations|Maternal Behavior
Interventions: BEHAVIORAL: Mindfulness-Based Childbirth and Parenting|BEHAVIORAL: Non-Mindfulness-Based Childbirth Class
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nintedanib Alone or in Combination With Capecitabine in Refractory Metastatic Colorectal Cancer [LUME-Colon 2]
Status: TERMINATED
Conditions: Colorectal Neoplasms
Interventions: DRUG: Nintedanib|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency and Cryoablation of the Posterior Wall of the Left Atrium
Status: RECRUITING
Conditions: Stroke|Acute Cerebrovascular Accident|Transient Ischemic Attack|Death|Atrial Fibrillation Recurrent
Interventions: PROCEDURE: Cryoablation|PROCEDURE: Radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Eplivanserin and Lormetazepam in the Treatment of Insomnia Characterized by Sleep Maintenance Difficulties
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders
Interventions: DRUG: eplivanserin (SR46349)|DRUG: lormetazepam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Dulaglutide in Chinese Participants
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Healthy Volunteers
Interventions: DRUG: Dulaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quantitative Evaluation of Parafoveal Microvasculature Changes in Eyes With Exudative Circumscribed Choroidal Haemangioma: An Optical Coherence Tomography Angiography Study
Status: COMPLETED
Conditions: Circumscribed Choroidal Haemangioma|Optical Coherence Tomography Angiography|Macular
Interventions: OTHER: This is observational study with the examination of OCTA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Use of Hyperbaric Oxygen to Increase the Blood Supply in the Injured, But Still Alive Tissue, Around an Old Stroke
Status: WITHDRAWN
Conditions: Ischemic Cerebrovascular Accident
Interventions: OTHER: hyperbaric oxygen chamber
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of HS-10501 Tablets in Healthy Subjects
Status: RECRUITING
Conditions: Healthy Subjects
Interventions: DRUG: HS-10501 tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Light Heart Study: Daily Light Box Use for Depressive Symptoms in Patients With Stage B Heart Failure
Status: UNKNOWN
Conditions: Depression|Stage B Heart Failure
Interventions: DEVICE: LiteBook|DEVICE: LiteBook
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Two Treatment Methods Compared the Sclerosing Agent Injection and the Rubber Wrapping
Status: UNKNOWN
Conditions: Hemorrhoid|Hemorrhoids|Hemorrhoids Internal|Hemorrhoid Prolapse|Hemorrhoid Bleeding|Hemorrhoid Pain
Interventions: OTHER: Endoscopic injection sclerotherapy|OTHER: Endoscopic Band Ligation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Obstructive Pulmonary Disease (COPD) Post-hospitalization Study
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: ADVAIR DISKUS 250/50 mg BID|DRUG: SEREVENT 50 mcg BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective, Randomized Trial of Ticagrelor Versus Prasugrel in Patients With Acute Coronary Syndrome
Status: COMPLETED
Conditions: Acute Coronary Syndrome (ACS)
Interventions: DRUG: Ticagrelor|DRUG: Prasugrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Efficacy and Safety of Biosimilar Candidate Xlucane Versus Lucentis® in Patients With nAMD
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: BIOLOGICAL: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Extra Virgin Olive Oil (EVOO) Supplementation on Hand-Foot Syndrome Incidence in Patients With Capecitabine
Status: ACTIVE_NOT_RECRUITING
Conditions: Hand and Foot Skin Reaction|Hand and Foot Syndrome|Capecitabine
Interventions: DIETARY_SUPPLEMENT: Extra Virgin Olive Oil|DIETARY_SUPPLEMENT: Olive Oil|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Dose-Proportionality and Intra-Individual Variability of Intracellular TFV-DP and FTC-TP in Healthy Volunteers
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Emtricitabine/tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pandemic Influenza Plasmid DNA Vaccines (Needle)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: VCL-IPT1|BIOLOGICAL: VCL-IPT1|BIOLOGICAL: VCL-IPT1|BIOLOGICAL: VCL-IPM1|BIOLOGICAL: PBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Transcranial Direct Current Stimulation for the Treatment of Delirium
Status: UNKNOWN
Conditions: Delirium|Confusion
Interventions: DEVICE: Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tacrolimus, Sirolimus and Ustekinumab vs. Tacrolimus and Sirolimus for the Prevention of Acute Graft-Versus-Host Disease
Status: COMPLETED
Conditions: Graft vs. Host Disease
Interventions: DRUG: Ustekinumab|DRUG: Placebo|DRUG: Tacrolimus (TAC)|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics/Pharmacodynamics (PK/PD) of Caspofungin in Intensive Care Unit (ICU) Patients. An Open Observational Study for Antifungal Treatment's Optimization
Status: COMPLETED
Conditions: Critical Illness|Infection
Interventions: DRUG: Caspofungin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Multiple-Dose Study of Bulevirtide in Participants With Normal and Impaired Renal Function
Status: RECRUITING
Conditions: Chronic Hepatitis D Infection
Interventions: DRUG: Bulevirtide (BLV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Disturbances of Kynurenine Pathway of Trytophan Metabolism in Schizophrenia: A Quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR) Study
Status: COMPLETED
Conditions: Schizophrenia
Interventions: PROCEDURE: Phlebotomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment Optimization of Brain-injured Warfighters
Status: RECRUITING
Conditions: Mild Traumatic Brain Injury
Interventions: BEHAVIORAL: Sub-symptomatic Adaptable Exercise Treatment (SAET)|BEHAVIORAL: Stretching Control Group (SCG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Cyanobacteria Patients With Chronic Hepatitis B Surface Antigen Quantitative Concentration
Status: UNKNOWN
Conditions: HBV Carrier
Interventions: DIETARY_SUPPLEMENT: Standard Dose Spirulina Platensis|OTHER: Zero Spirulina Platensis|DIETARY_SUPPLEMENT: Double Dose Spirulina Platensis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification and Quantification of Immune Response Induced by Hyaluronidase and Other Factors of Virulence of Invasive Human Infections of Streptococcus Pneumoniae
Status: COMPLETED
Conditions: Invasive Pneumococcic
Interventions: BIOLOGICAL: Sampling of blood
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Atrial Fibrillation and Carotid Atherosclerosis in Ischemic Stroke Patients-(AFCAS)
Status: UNKNOWN
Conditions: Ischemic Stroke|Atrial Fibrillation|Carotid Stenosis
Interventions: BIOLOGICAL: Carotid Stenosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Determine if Gloving in Addition to Hand Hygiene Will Prevent Invasive Infections and Necrotizing Enterocolitis
Status: COMPLETED
Conditions: Neonatal Infection|Neonatal Necrotizing Enterocolitis
Interventions: OTHER: Gloves
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Home-Based Exercise in Primary Progressive Aphasia (HEPPA)
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Progressive Aphasia|Neurodegenerative Diseases|Logopenic Progressive Aphasia|Semantic Dementia|Non-fluent Aphasia
Interventions: OTHER: Home-based multicomponent exercise intervention program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Milnacipran in Autism and the Functional Locus Coeruleus and Noradrenergic Model of Autism
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Asperger Syndrome|Aspergers Syndrome
Interventions: DRUG: Milnacipran|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness Training Effect on Self-monitoring Adherence and Group CBT Outcomes for Binge Eating Disorders
Status: UNKNOWN
Conditions: Bulimia Nervosa|Binge-Eating Disorder|Night-eating Syndrome
Interventions: BEHAVIORAL: MIND|BEHAVIORAL: CBT-E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Survival Rate After TheraCal PT Pulpotomy Versus MTA Pulpotomy in Children With Vital Primary Molars.
Status: UNKNOWN
Conditions: Reversible Pulpitis
Interventions: DRUG: MTA|DRUG: TheraCal PT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of ROFLUMILAST on Subclinical Atherosclerosis in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease and Allied Conditions
Interventions: DRUG: Roflumilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Hematopoietic Stem Cell Transplantation for Refractory Autoimmune Diseases
Status: UNKNOWN
Conditions: Autoimmune Diseases
Interventions: PROCEDURE: Autologous hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Urodynamic Evaluation of Disobstrucitve Power of Aquablation VS Laser Techniques
Status: UNKNOWN
Conditions: Benign Prostatic Hyperplasia (BPH)
Interventions: DEVICE: aquablation|DEVICE: holep|DEVICE: pvp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VELCADE in Combination With Idarubicin and Cytosine Arabinoside in Patients With Acute Myelogenous Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: velcade|DRUG: Idarubicin|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of a Tele-Physiotherapy Tool for the Early Management of Muskuloskeletal Pain in People With Visual Impairement (TeleEDxPhysio)
Status: RECRUITING
Conditions: Low Back Pain|Visual Impairment
Interventions: BEHAVIORAL: physical exercise|OTHER: Manual therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nintedanib (BIBF 1120) in Mesothelioma
Status: TERMINATED
Conditions: Mesothelioma
Interventions: DRUG: Nintedanib|DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Cisplatin|DRUG: Pemetrexed|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: To Compare the Strategies of Universal Antibiotic Prophylaxis Versus Screen-and-treat in Reducing Infective Complications and Re-infection in Women Who Undergo Termination of Pregnancy
Status: COMPLETED
Conditions: Induced Abortion|Postaboral Pelvic Inflammatory Disease|Sexually Transmitted Infections
Interventions: DRUG: Universal antibiotic prophylaxis|OTHER: Screen-and-treat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Influence of Phenotype, Grapefruit Juice and Orange Juice on the Pharmacokinetics of Sunitinib in Cancer Patients
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Sunitinib|DRUG: Midazolam|OTHER: Orange juice|OTHER: Grapefruit juice
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Study of Adavosertib (MK-1775) in Combination With Topotecan/Cisplatin in Participants With Cervical Cancer (MK-1775-008)
Status: TERMINATED
Conditions: Cervical Cancer
Interventions: DRUG: adavosertib|DRUG: Topotecan|DRUG: Cisplatin|DRUG: Placebo to adavosertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mass Balance and Pharmacokinetics (PK) of [14C]-DC-806 in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: DC-806|DRUG: [14C]-DC-806
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Kuvan Therapy in Phenylketonuria (PKU): The Effect of Blood Phenylalanine Concentration on Kuvan Response
Status: COMPLETED
Conditions: Phenylketonuria
Interventions: DRUG: Kuvan|OTHER: Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Binaural Beats and 432Hz Music for Reduction of Preoperative Anxiety in Root Canal Patients
Status: COMPLETED
Conditions: Dental Anxiety
Interventions: BEHAVIORAL: 432 Hz music|BEHAVIORAL: Binaural beats|BEHAVIORAL: White noise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vildagliptin and the Glucagon Response to Hypoglycemia in Insulin-Treated Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: Vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy Study of the Z-Lig Medical Device Compared to Allograft
Status: UNKNOWN
Conditions: Ruptured Anterior Cruciate Ligaments
Interventions: DEVICE: Z-Lig|DEVICE: allograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Body Composition and Hormonal Status in Ataxia Telangiectasia
Status: COMPLETED
Conditions: Ataxia Telangiectasia
Interventions: PROCEDURE: bioelectrical impedance analysis|PROCEDURE: blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pixantrone (BBR 2778) in Patients With Refractory Acute Myelogenous Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia
Interventions: DRUG: Pixantrone IV infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Response of High-dose and Standard-dose Rabeprazole for Extra-esophageal Reflux.
Status: COMPLETED
Conditions: Esophageal Disease
Interventions: DRUG: Rabeprazole 20mg bid|DRUG: Rabeprazole 20mg qd
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Program for Obstructive Sleep Apnea With Severe Obesity
Status: RECRUITING
Conditions: Obstructive Sleep Apnea|Obesity
Interventions: BEHAVIORAL: Home-based pulmonary rehabilitation (PR) system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: To Determine the Effectiveness of Saddle Block vs Spinal Anesthesia in TURP
Status: COMPLETED
Conditions: Haemodynamic Instability
Interventions: DRUG: 0.5% Hyperbaric Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Postoperative Nausea-Vomiting in Laparoscopic Cholecystectomy: Peppermint-Flavored Gum Versus Gum-Free
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting|Chewing Gum
Interventions: DIAGNOSTIC_TEST: Abramowitz Emesis Score|DIAGNOSTIC_TEST: Degree of nausea|DIAGNOSTIC_TEST: Observer's Assessment of Alertness/Sedation Scale|DIAGNOSTIC_TEST: Patient Satisfaction|DIAGNOSTIC_TEST: Surgeon Satisfaction|OTHER: Chewing Peppermint gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oleclumab and Durvalumab for the Treatment of Recurrent, Refractory, or Metastatic Sarcoma
Status: RECRUITING
Conditions: Metastatic Angiosarcoma|Metastatic Dedifferentiated Liposarcoma|Metastatic Osteosarcoma|Recurrent Angiosarcoma|Recurrent Dedifferentiated Liposarcoma|Recurrent Osteosarcoma|Refractory Dedifferentiated Liposarcoma|Refractory Osteosarcoma
Interventions: BIOLOGICAL: Durvalumab|BIOLOGICAL: Oleclumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mycophenolate Mofetil Combined With Radiation Therapy in Glioblastoma
Status: RECRUITING
Conditions: Recurrent Glioblastoma|Recurrent Gliosarcoma|Recurrent Astrocytoma, Grade IV|Newly Diagnosed Glioblastoma|Newly Diagnosed Gliosarcoma|Newly Diagnosed Astrocytoma, Grade IV
Interventions: DRUG: Mycophenolate Mofetil|RADIATION: Radiation Therapy|PROCEDURE: Re-resection (as part of standard of care)|DRUG: Temozolomide|DRUG: Mycophenolate Mofetil|DRUG: Mycophenolate Mofetil|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Efficacy Study of V117957 in Subjects With Insomnia Associated With Alcohol Cessation
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: V117957 tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Two Formulations of LY3074828 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: LY3074828|DRUG: LY3074828|DEVICE: Auto-injector (AI)|DEVICE: Prefilled syringe (PFS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ceramic-on-Ceramic Total Hip Arthroplasty and Squeaking: Influence of Component Design
Status: COMPLETED
Conditions: Hip Arthrosis
Interventions: DEVICE: THA with ABG II / Trident|DEVICE: THA with CLS / Trilogy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combination With Chemotherapy With/Without Bevacizumab for Hepatic Metastases From Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatic Metastases|Colon Cancer|Rectal Cancer
Interventions: DRUG: Bevacizumab HAI plus systemic chemotherapy|DRUG: HAI plus systemic chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT