pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Anifrolumab Treatment for 24 Weeks in Patients With Primary Sjögren's Syndrome
Status: RECRUITING
Conditions: Sjogren's Syndrome
Interventions: DRUG: Anifrolumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and Pharmacokinetics
Status: COMPLETED
Conditions: Transposition of the Great Arteries|Tetralogy of Fallot|Ventricular Septal Defect
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irinotecan Liposomes in Combination With Nituzumab for the Treatment of Recurrent/Metastatic Nasopharyngeal Carcinoma After Failure of First-Line or Higher Immunotherapy
Status: NOT_YET_RECRUITING
Conditions: Nasopharyngeal Cancer
Interventions: DRUG: Irinotecan Liposomal combined With Nituzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Valvuloplasty as Alternative to Toupet Fundoplication for GERD
Status: WITHDRAWN
Conditions: Gastroesophageal Reflux|Hernia, Hiatal
Interventions: PROCEDURE: Laparoscopic gastroesophageal valvuloplasty|PROCEDURE: Laparoscopic Toupet fundoplication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of KRN23 (Burosumab), a Recombinant Fully Human Monoclonal Antibody Against Fibroblast Growth Factor 23 (FGF23), in Pediatric Subjects With X-linked Hypophosphatemia (XLH)
Status: COMPLETED
Conditions: X-linked Hypophosphatemia
Interventions: BIOLOGICAL: burosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1a/1b Study of ELVN-001 for the Treatment Chronic Myeloid Leukemia
Status: RECRUITING
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: ELVN-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fractional Flow Reserve to Determine Atherosclerosis Renovascular Hypertension Stenting
Status: RECRUITING
Conditions: Renal Artery Stenosis Atherosclerotic|Secondary Hypertension Renal Arterial
Interventions: DRUG: Dopamine|DIAGNOSTIC_TEST: Fractional Flow Reserve, Renal|DEVICE: Renal artery stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of Vitamin D and Calcium Supplementation to Parathyroid Hormone in CHB Patients Treated With TDF
Status: COMPLETED
Conditions: Parathyroid Hormone|Tenofovir Disoproxil Fumarate|Chronic Hepatitis B Virus|Vitamin D
Interventions: DRUG: Ergocalciferol Capsules|DRUG: Calcium carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bionic Pancreas in CFRD
Status: NOT_YET_RECRUITING
Conditions: Cystic Fibrosis-related Diabetes
Interventions: DEVICE: iLet Bionic Pancreas System (BP)|DEVICE: Usual Care (UC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of a Topical Gel for the Treatment of Mild to Moderate Psoriasis
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: PTH (1-34) Gel / Placebo Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Study of IVIG vs. IVIG With High Dose Methylprednisolone in Childhood ITP.
Status: COMPLETED
Conditions: Immune Thrombocytopenic Purpura
Interventions: DRUG: Methylprednisolone and IVIG|DRUG: Placebo and IVIG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Abdominal Muscle Exercises on Nocturia and Sleep Quality in Women With Type 2 Diabetes
Status: COMPLETED
Conditions: Nocturia|Sleep Deprivation
Interventions: BEHAVIORAL: pelvic floor exercise|BEHAVIORAL: Abdominal muscles exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Acenocoumarol for Treatment of Nontumor Portal Vein Thrombosis in Cirrhosis of Liver
Status: WITHDRAWN
Conditions: Portal Vein Thrombosis
Interventions: DRUG: Enoxaparin with acenocoumarol|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A RCT of Walking With Positive Education in Retired Elders
Status: COMPLETED
Conditions: Happiness|Educational Problems|Exercise
Interventions: BEHAVIORAL: Pedometer walking training and positive education|BEHAVIORAL: Pedometer walking with training|BEHAVIORAL: pedometer walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of a Nitrate Supplementation on Erectile Function
Status: RECRUITING
Conditions: Erectile Dysfunction
Interventions: DIETARY_SUPPLEMENT: Nitric Oxide|DRUG: Tadalafil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: E7080 (Lenvatinib) in Combination With Dacarbazine Versus Dacarbazine Alone as First Line Therapy in Patients With Stage IV Melanoma
Status: COMPLETED
Conditions: Stage IV Melanoma
Interventions: DRUG: Lenvatinib|DRUG: Lenvatinib|DRUG: Dacarbazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extending Urine Analysis By Direct Mass Spectrometry
Status: COMPLETED
Conditions: Urinary Tract Infection (Diagnosis)
Interventions: OTHER: Conventional microbiological identification by culture plate|OTHER: Direct mass spectrometry identification from urine sample
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Efficacy And Cognitive Impairment Of Modified Electroconvulsive Therapy
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Etomidate|DRUG: Propofol|DEVICE: Bilateral temporal MECT|DEVICE: The right temporal MECT|DEVICE: Bilateral frontal MECT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Capecitabine in Combination With Cisplatin and Irinotecan
Status: COMPLETED
Conditions: Solid Tumors|Cancer
Interventions: DRUG: Capecitabine in Combination with Cisplatin and Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dopamine on Diabetic Retinopathy
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: Low Dose Sinemet CR|DRUG: High Dose Sinemet CR|DEVICE: RETeval Electroretinogram (ERG) Testing|OTHER: Contrast Sensitivity Testing|OTHER: Visual Acuity Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Induction and Expansion of T Cell Repertoire Using Growth Hormone and Vaccination in HIV-1 Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: recombinant human Growth Hormone|BIOLOGICAL: Vaccination|DRUG: HAART
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diphenhydramine and Sweating
Status: COMPLETED
Conditions: Diphenhydramine Causing Adverse Effects in Therapeutic Use|Hyperthermia|Allergic Rhinitis|Sweating
Interventions: DRUG: Placebo|DRUG: Diphenhydramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Value of Rituximab in Humoral Chronic Rejection After Renal Transplantation
Status: TERMINATED
Conditions: Grafting|Renal Transplantation|Transplantation, Kidney|Chronic Allograft Nephropathy
Interventions: DRUG: MabThera
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Core Needle Biopsy and Cryoablation of an Enlarging Tumor in Patients With Metastatic Lung Cancer and Metastatic Melanoma Receiving Post-progression Immune Checkpoint Inhibitor Therapy
Status: COMPLETED
Conditions: Lung Cancer
Interventions: PROCEDURE: Cryoablation|PROCEDURE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SAR407899 Single-dose in Treatment of Mild to Moderate Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: SAR407899|DRUG: Placebo|DRUG: Sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Indashyikirwa IPV Prevention Trial in Rwanda
Status: COMPLETED
Conditions: Intimate Partner Violence
Interventions: BEHAVIORAL: Indashyikirwa Couples Training|BEHAVIORAL: Indashyikirwa Activist Training|BEHAVIORAL: Indashyikirwa Opinion Leader Training|OTHER: Indashyikirwa Women's Spaces|BEHAVIORAL: Village Savings and Loan Association (VSLA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Andexanet Alfa and 4F-PCC Use in Patients Hospitalised With an Anticoagulant-related Major Bleed
Status: COMPLETED
Conditions: Anticoagulant-related Major Bleed
Interventions: DRUG: Andexanet alfa|DRUG: 4F-PCC
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Negative Pleural Suction for Tube Thoracostomy in Patients With Chest Trauma
Status: COMPLETED
Conditions: Hemothorax|Pneumothorax|Hemopneumothorax|Chest Injury Trauma Blunt|Chest Injury Trauma|Chest Injury Penetrating Wound
Interventions: OTHER: Negative Pleural Suction at -20 cm H2O|OTHER: Water seal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Vaginal Tablets, Produced at Different Sites, in Postmenopausal Women With Atrophic Vaginitis
Status: COMPLETED
Conditions: Menopause|Postmenopausal Vaginal Atrophy
Interventions: DRUG: estradiol, 25 mcg|DRUG: estradiol, 25 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sotorasib in KRAS G12C Mutated, Resectable, Stage Ib-IIIA NSCLC
Status: WITHDRAWN
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Sotorasib, 960 mg, oral daily dose for 4 weeks (28 days)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultra Violet B Radiation (UVR) Study of Strontium Chloride Hexahydrate Hydrocortisone
Status: COMPLETED
Conditions: Erythema|Pain
Interventions: DRUG: Hydrocortisone|DRUG: 2PX+|DRUG: 2PX-
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety of Two Influenza Vaccines in Children and Adolescents 3 to <18 Years of Age at Risk for Influenza-Related Complications
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: TIVc|BIOLOGICAL: TIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fiber and Calcium Absorption in Older Men
Status: NOT_YET_RECRUITING
Conditions: Aging
Interventions: DIETARY_SUPPLEMENT: Soluble corn fiber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Randomized Trial of Creatine-kinase Leak After Rosuvastatin At the Time of Percutaneous Coronary Intervention
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation Program as an Alternative Therapy for Moderate to Severe Obstructive Sleep Apnea Syndrome
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive|Metabolic Syndrome
Interventions: BEHAVIORAL: In-patient rehabilitation|BEHAVIORAL: Educational activities alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of MW031 in PMO Subjects
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal
Interventions: DRUG: MW031|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Tolperisone on Measures of Drowsiness and Cognitive Function
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tolperisone Hydrochloride|DRUG: Cyclobenzaprine Hydrochloride 10 MG|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tanshinone in Polycystic Ovary Syndrome
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: tanshinone|DRUG: tanshinone placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Platelet-rich Fibrin and Vitamin Dꝫ Injections on the Periodontal Health
Status: RECRUITING
Conditions: Periodontal Health
Interventions: OTHER: Platelet-rich Fibrin|OTHER: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Injectable Alb-PRF in the Management of Intrabony Defect in Stage-III Periodontitis Patients
Status: NOT_YET_RECRUITING
Conditions: Intrabony Periodontal Defect
Interventions: PROCEDURE: Albumin Platelet Rich Fibrin (Alb-PRF) combined with minimally invasive surgical technique (MIST)|PROCEDURE: Minimally invasive surgical technique (MIST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determination of the Role of Microarray for Prognosis and Prediction to Chemotherapy Sensitivity in Patients With Operable, Locally Advanced and Metastatic Oesophageal Cancer
Status: UNKNOWN
Conditions: Oesophageal Cancer
Interventions: PROCEDURE: Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Endoscopic Biopsy Techniques in Barrett's Esophagus Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Barrett Esophagus
Interventions: OTHER: Biopsy technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Staying Strong and Healthy During Androgen Deprivation Therapy (ADT) for Men
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BEHAVIORAL: Exercise Program|BEHAVIORAL: Diet and Nutrition Coaching|OTHER: Usual Care with Attention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of 18F-DCFPyL PSMA- Versus 18F-NaF-PET Imaging for Detection of Metastatic Prostate Cancer.
Status: COMPLETED
Conditions: Metastatic Prostate Cancer
Interventions: DRUG: 18F-DCFPyL Injection|DRUG: 18F-NaF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Egg-derived Influenza Vaccine and Cell Culture-derived Influenza Vaccine in Healthy Children and Adolescents
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: NBP607|BIOLOGICAL: Agrippal S1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Analgesic Efficacy of Dexmedetomidine as Adjuvant to Levobupivacaine in Ultrasound-guided Erector Spinae Plan Block for Modified Radical Mastectomy
Status: UNKNOWN
Conditions: Acute Pain
Interventions: PROCEDURE: erector spinae block with bupivacaine|PROCEDURE: erector spinae block with bupivacaine and dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of PC6 Electroacupuncture in the Prevention of Nausea Vomiting in Caesarean Patient Under Spinal Anaesthesia
Status: UNKNOWN
Conditions: Postoperative Nausea and Vomiting
Interventions: PROCEDURE: Electroacupuncture on acupoints vs sham points
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intratracheal Budesonide With Surfactant to Prevent Bronchopulmmonary Dysplasia.
Status: NOT_YET_RECRUITING
Conditions: Bronchopulmonary Dysplasia|Respiratory Distress Syndrome in Premature Infant|Prematurity
Interventions: DRUG: Poractant Alfa Intratracheal Suspension [Curosurf]|DRUG: Budesonide 0.5 MG/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Simufilam 50 mg or 100 mg for Mild-to-Moderate Alzheimer's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: Simufilam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Endovascular Repair of Complex Aortic Pathology With Physician-modified Endovascular Grafts (PMEGs)
Status: RECRUITING
Conditions: Abdominal Aortic Aneurysm|Thoracoabdominal Aortic Aneurysm|Aortic Dissection
Interventions: DEVICE: Endovascular aortic repair with a physician-modified endovascular graft (PMEG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate The Safety And Tolerability Of PF-03882845 In Patients With Type 2 Diabetic Nephropathy
Status: TERMINATED
Conditions: Type 2 Diabetic Nephropathy
Interventions: DRUG: PF-03882845|DRUG: PF-03882845|DRUG: PF-03882845|DRUG: Spironolactone|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacokinetics of Lopinavir/Ritonavir Superboosting in Infants and Young Children Co-infected With HIV and TB
Status: COMPLETED
Conditions: Acquired Immunodeficiency Syndrome|Tuberculosis
Interventions: DRUG: lopinavir with ritonavir in 1:1 ratio|DRUG: Lopinavir/ritonavir 4:1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of SHR-1802 in Combination With Adebrelimab in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: BIOLOGICAL: Adebrelimab|BIOLOGICAL: SHR-1802|DRUG: Carboplatin/Cisplatin|DRUG: Paclitaxel/Nab-Paclitaxel/Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Intensive Program With Quadruplet Induction and Consolidation Plus Tandem Autologous Stem Cell Transplantation in Newly Diagnosed High Risk Multiple Myeloma Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Carfilzomib|DRUG: Daratumumab|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DXA Precision and Accuracy Comparison Study
Status: TERMINATED
Conditions: Osteopenia
Interventions: DEVICE: Lunar Prodigy (GEHC)|DEVICE: Lunar iDXA (GEHC)|DEVICE: Discovery A (Hologic
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Improved Skin Anti-aging Outcomes Associated With Collagen Fortified Consumption In 30 to 50-Year-old Women
Status: COMPLETED
Conditions: Skin Laxity|Skin Lines
Interventions: DIETARY_SUPPLEMENT: Study product plus collagen supplement|DIETARY_SUPPLEMENT: Study product without collagen supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ticagrelor Administered as Standard Tablet or Orodispersible Formulation
Status: COMPLETED
Conditions: ST Elevation Myocardial Infarction|NSTEMI - Non-ST Segment Elevation MI
Interventions: DRUG: Ticagrelor orodispersible tablets|DRUG: Ticagrelor standard tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Investigate the Effect of Cytotoxic Therapy and/or Radiotherapy on Cancer Related Sleep Disturbances in CLL and Breast Cancer Patients Experiencing Fatigue
Status: COMPLETED
Conditions: Leukemia|CLL
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myocardial Perfusion, Oxidative Metabolism, and Fibrosis in HFpEF
Status: COMPLETED
Conditions: Heart Failure, Diastolic|Diastolic Heart Failure|Hypertension
Interventions: DRUG: regadenoson
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Networked-Based Recovery With User Involvement
Status: WITHDRAWN
Conditions: Psychiatric Hospitalization
Interventions: OTHER: An educational support model called RENEW (Rehabilitation for Empowerment, Natural Support, Education and Work) targeting young people with mental health difficulties.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate Nivolumab in Combination With Ipilimumab Versus Pemetrexed With Cisplatin or Carboplatin for Unresectable Pleural Mesothelioma in Chinese Participants
Status: RECRUITING
Conditions: Mesothelioma, Malignant
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: Ipilimumab|DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Usefulness of Assessing Heart Rate Variability in Patients With Acute Myocardial Infarction
Status: NOT_YET_RECRUITING
Conditions: Myocardial Infarction|Autonomic Dysfunction
Interventions: PROCEDURE: Heart rate variability measurement|PROCEDURE: Percutaneous coronary intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Whey Protein on Short-Term Food Intake and Post-Meal Blood Glucose Response in Young Men
Status: COMPLETED
Conditions: Diabetes Prevention|Obesity Prevention
Interventions: OTHER: dietary intervention|OTHER: water control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Blood/Imaging Based Biomarkers, Aromatase Inhibitor Induced Musculoskeletal Syndrome
Status: COMPLETED
Conditions: Aromatase Inhibitor Induced Musculoskeletal Syndrome (AIMSS)|Breast Cancer
Interventions: DIAGNOSTIC_TEST: Initial blood draw|DIAGNOSTIC_TEST: Initial SWE ultrasound|DIAGNOSTIC_TEST: Blood draw at three months|DIAGNOSTIC_TEST: Blood draw at six months|DIAGNOSTIC_TEST: SWE ultrasound at six months
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Elastography and 2-Point Dixon MR Imaging Techniques in Diffuse Liver Disease
Status: COMPLETED
Conditions: Liver Cancer
Interventions: DIAGNOSTIC_TEST: Magnetic Resonance Elastogram|DIAGNOSTIC_TEST: 2-Point Dixon Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Zinc and Selenium Supplementation in Atherosclerosis
Status: COMPLETED
Conditions: Dietary Selenium Deficiency|Dietary Zinc Deficiency
Interventions: DIETARY_SUPPLEMENT: zinc and selenium supplementation|OTHER: rosuvastatin + placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Compound Edaravone Injection for Treatment of Acute Ischemic Stroke
Status: SUSPENDED
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Compound Edaravone Injection-Low dose|DRUG: Compound Edaravone Injection-High dose|DRUG: Edaravone Injection|DRUG: Placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Self-Care for Dementia Caregivers
Status: RECRUITING
Conditions: Aging|Mental Disorder|Eating, Healthy|Physical Inactivity|Prodromal Symptoms|Sleep|Alzheimer Disease|Dementia|Circadian Rhythm Disorders
Interventions: BEHAVIORAL: Behavioral Self-Monitoring + Motivational Interviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Oral Miltefosine in Patients With Post Kala Azar Dermal Leishmaniasis (PKDL)
Status: COMPLETED
Conditions: PKDL
Interventions: DRUG: Miltefosine|DRUG: Miltefosine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FOCUS for Pediatric Sickle Cell Disease and Cancer
Status: UNKNOWN
Conditions: Pediatric Cancer|Sickle Cell Disease|Quality of Life|Depressive Symptoms|Coping Skills
Interventions: BEHAVIORAL: FOCUS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trivalent Baculovirus-expressed Influenza HA Vaccine in Adults With Non-Hodgkin's B-cell Lymphoma
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Trivalent inactivated influenza vaccine|BIOLOGICAL: Trivalent Baculovirus-expressed Influenza HA vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Preoxygenation With Optiflow™ in Morbidly Obese Patients is Superior to Face Mask
Status: WITHDRAWN
Conditions: Obesity, Morbid
Interventions: DEVICE: Optiflow F&P 850™ System|DEVICE: facemask|DRUG: Rocuronium|DRUG: Propofol|DRUG: Fentanyl|DRUG: Midazolam|DEVICE: C-MAC Premium Video Intubation Platform-KARL STORZ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Metabolaid® on AMPK Activation for Weight Loss
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Metabolaid®|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Rehabilitation After Acute Coronary Syndrome: a New Telemonitoring Strategy
Status: COMPLETED
Conditions: Angina, Unstable|Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)|ST-segment Elevation Myocardial Infarction (STEMI)
Interventions: DEVICE: telemonitoring|OTHER: Centre-based cardiac rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence
Status: RECRUITING
Conditions: Diabetes|Hypertension|High Cholesterol/Hyperlipidemia|Coronary Artery Disease|Congestive Heart Failure|Chronic Lung Disease|Chronic Kidney Diseases|Arrythmia|Stroke|Depression|Anxiety|Pulmonary Embolism|Heart Attack
Interventions: OTHER: Med AAAction intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Short-Term Use of Antibiotics and Adherence Level
Status: COMPLETED
Conditions: Acute Infection
Interventions: BEHAVIORAL: Routine care by the dispensing pharmacist|BEHAVIORAL: Pharmaceutical education/counseling about prescribed antibiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of a High Protein and Low Glycemic Index Diet on Kidney Transplant Recipients
Status: UNKNOWN
Conditions: Kidney Failure, Chronic|End-Stage Renal Disease
Interventions: BEHAVIORAL: High Protein and Low Glycemic Index Diet|BEHAVIORAL: Conventional Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Different Anesthetic Techniques on QT, Corrected QT (QTc), and P Wave Dispersions in Cesarean Section
Status: COMPLETED
Conditions: Caesarean Section|Anesthesia; Reaction
Interventions: DRUG: Bupivacaine|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Aripiprazole and Haloperidol on Mesolimbic System Functioning
Status: COMPLETED
Conditions: Psychosis|Schizophrenia
Interventions: DRUG: Aripiprazole|DRUG: Haloperidol|DRUG: Placebo sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tumor Infiltrating Lymphocyte Therapy for Pediatric High Risk Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Lymphocytes
Interventions: BIOLOGICAL: Tumor Infiltrating Lymphocytes, Fludarabine, Cyclophosphamide, Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Direct Oral Penicillin Challenge in a Rural Community
Status: RECRUITING
Conditions: Allergy Penicillin
Interventions: OTHER: Screening|DRUG: Low dose Penicillin|DRUG: Standard dose Penicillin|OTHER: Remove allergy label
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053)
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Neoplasms
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Placebo for pembrolizumab|DRUG: Docetaxel|DRUG: Cisplatin|RADIATION: External Beam Radiotherapy (EBRT)|DRUG: Cisplatin (as radiosensitizer)|RADIATION: Brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of CPAP Treatment in Patients With Severe Uncontrolled Asthma: The ASTHMA-SLEEP Trial
Status: NOT_YET_RECRUITING
Conditions: Obstructive Sleep Apnea|Asthma
Interventions: DEVICE: CPAP treatment|OTHER: Hygienic and dietary advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ecabet Sodium and Proton Pump Inhibitor Combination Therapy in the Treatment of Iatrogenic Ulcer After Endoscopic Submucosal Dissection
Status: UNKNOWN
Conditions: Delayed Bleeding,|Healing Ulcer|Quality of Ulcer
Interventions: DRUG: Ecabet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Electro-acupuncture on Women With Diminished Ovarian Reserve
Status: RECRUITING
Conditions: Diminished Ovarian Reserve
Interventions: OTHER: Treatment group protocol|OTHER: Control group protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HER3-DXd (Patritumab Deruxtecan; U3-1402) in Combination With Osimertinib in Subjects With Locally Advanced or Metastatic EGFR-mutated Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Lung Cancer (NSCLC)
Interventions: DRUG: HER3-DXd|DRUG: HER3-DXd|DRUG: Osimertinib|DRUG: Osimertinib|DRUG: HER3-DXd|DRUG: HER3-DXd|DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhanced Platelet Inhibition in Critically Ill Patients With COVID-19
Status: COMPLETED
Conditions: Pneumonia, Viral|Corona Virus Infection|Respiratory Failure|Embolism and Thrombosis
Interventions: DRUG: Tirofiban Injection|DRUG: Clopidogrel|DRUG: Acetylsalicylic acid|DRUG: Fondaparinux
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of PN40082 for Lip Augmentation
Status: COMPLETED
Conditions: Lip Augmentation
Interventions: DEVICE: PN40082|DEVICE: Restylane Silk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dasatinib and Bevacizumab in Treating Patients With Recurrent or Progressive High-Grade Glioma or Glioblastoma Multiforme
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: BIOLOGICAL: bevacizumab|DRUG: dasatinib|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Visual Cue as Prevention of Pulmonary Infection Under Mechanical Ventilation
Status: UNKNOWN
Conditions: Pulmonary Infection
Interventions: OTHER: With visual cue and nurses informed|OTHER: Without visual cue and nurses informed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prevalence and Severity of Venous Thromboembolism in a General Population During the COVID-19 Pandemic
Status: COMPLETED
Conditions: COVID-19|Venous Thromboembolism|Pulmonary Embolism|Deep Vein Thrombosis|SARS-CoV 2
Interventions: DIAGNOSTIC_TEST: Diagnostic examination for venous thromboembolism
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Trial on Immunosuppression Modulation to Increase SARS-CoV-2 Vaccine Response in Kidney Transplant Recipients
Status: UNKNOWN
Conditions: COVID-19
Interventions: OTHER: Immunosuppression reduction|OTHER: No immunosuppression reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparing Two Pneumococcal Vaccines in Adults With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: BIOLOGICAL: Pneumovax (PPSV23)|BIOLOGICAL: Prevnar (PCV7)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Influence of Dimensional Anatomic Variables on the Outcomes of Maxillary Sinus Grafting Procedures
Status: COMPLETED
Conditions: Edentulism|Alveolar Bone Atrophy|Sinus Pneumatization
Interventions: PROCEDURE: Sinus grafting using allogenic bone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 68Ga-DOTATATE PET-CTA Imaging for the Early Detection of Progressing Coronary Atherosclerosis
Status: TERMINATED
Conditions: Coronary Arteriosclerosis
Interventions: DRUG: injection of 68Ga-DOTATATE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Aflibercept After Ranibizumab in Exudative Age-related Macular Degeneration
Status: COMPLETED
Conditions: Macular Degeneration|Wet Macular Degeneration|Retinal Degeneration|Retinal Diseases|Eye Diseases
Interventions: DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trichuris Suis Ova (TSO) Suspension Versus Placebo in Active Crohn's Disease
Status: COMPLETED
Conditions: Crohn´s Disease
Interventions: DRUG: Low dose TSO|DRUG: Medium dose TSO|DRUG: High dose TSO|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: THERMARTHROSE: Gonarthrosis and Water Cure
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Pain
Interventions: DRUG: thermal cure|DRUG: 3 days access to watering place at 6 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of SinocrownTM Transcatheter Aortic Valve Replacement System
Status: ENROLLING_BY_INVITATION
Conditions: Transcatheter Aortic Valve Replacement
Interventions: DEVICE: SinocrownTM Transcatheter Aortic Valve Replacement System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Glioma Associated Antigen Vaccines in Conjunction With Poly-ICLC in Pediatric Gliomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Newly Diagnosed Pediatric Pontine Glioma|Newly Diagnosed Pediatric High Grade Glioma|Recurrent Pediatric High Grade Glioma|Recurrent Pediatric Low Grade Glioma
Interventions: BIOLOGICAL: HLA-A2 restricted glioma antigen peptides vaccine|BIOLOGICAL: Poly-ICLC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brightline-2: A Study to Test Whether Brigimadlin (BI 907828) Helps People With Cancer in the Biliary Tract, Pancreas, Lung or Bladder
Status: RECRUITING
Conditions: Pancreatic Neoplasms|Solid Tumors|Biliary Tract Cancer|Lung Neoplasms|Bladder Cancer
Interventions: DRUG: brigimadlin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization of Rectal Cancer Hypoxia Using pO2 Histography and Immunohistochemistry for Hypoxia-Related Proteins
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: PROCEDURE: Eppendorf hypoximeter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Craving & Decision-Making
Status: RECRUITING
Conditions: Decision Making
Interventions: BEHAVIORAL: Audio-visual stimuli (Neutral-Relaxing)|BEHAVIORAL: Audio-visual stimuli (Drug)|BEHAVIORAL: Audio-visual stimuli (Non-Food)|BEHAVIORAL: Audio-visual stimuli (Food)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Short-term Use of Dapagliflozin to Protect Kidney Function in CKD Patients
Status: UNKNOWN
Conditions: Renal Insufficiency, Chronic|Cardiac Catheterization|Percutaneous Coronary Intervention
Interventions: DRUG: Dapagliflozin 10 MG [Farxiga]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: D-dimer to Establish Duration of Anticoagulation After Venous Thromboembolism
Status: COMPLETED
Conditions: Deep Vein Thrombosis|Pulmonary Embolism
Interventions: DRUG: Vitamin K antagonist (Coumarin anticoagulants)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Ixazomib to Prevent Recurrent or Late Acute and Chronic Graft-versus-Host Disease 1-year After Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Hematologic Malignancies
Status: COMPLETED
Conditions: Myeloid Hematologic Malignancy|Lymphoid Hematologic Malignancy
Interventions: DRUG: Ixazomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Application of Neck Ultrasound in the Assessment of Peripherally Inserted Central Catheter (PICC) Tip Position
Status: COMPLETED
Conditions: Peripherally Inserted Central Catheter Insertion Technique
Interventions: OTHER: Ultrasound inspection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Partial Removal and Total Removal of the Corneal Epithelium on Keratoconus
Status: COMPLETED
Conditions: Keratoconus
Interventions: PROCEDURE: collagen cross-linking procedure (total removal)|PROCEDURE: collagen cross-linking procedure (partial removal)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Application of DNA Nanomachines for Detecting microRNA in Blood for the Diagnosis of Pancreatic Cancer. Diagnosis of Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreas Adenocarcinoma|MicroRNA
Interventions: GENETIC: MicroRNA (mir-642b-3p)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Placing the Endotracheal Tube Beyond Cervical C7 Level in Anterior Cervical Decompression and Fusion Surgery
Status: NOT_YET_RECRUITING
Conditions: Anterior Spinal Artery Compression Syndromes, Cervical Region
Interventions: PROCEDURE: ETT beyond C7 level
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Inhalation Aromatherapy on Anxiety and Depressive Symptoms of Geriatric Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Inhalation Aromatherapy
Interventions: COMBINATION_PRODUCT: Inhalation Aromatherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Light Therapy to Treat Depression in Pediatric Stem Cell Therapy Recipients
Status: NOT_YET_RECRUITING
Conditions: Hematopoietic Stem Cell Transplant
Interventions: DEVICE: Ayo wearable
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Periacetabular Osteotomy.A Prospective Study With Reference to Cartilage, Migration and Bone Density
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: PROCEDURE: 1 Periacetabular osteotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Eye Movement Desensitization and Reprocessing (EMDR) Working Mechanism
Status: UNKNOWN
Conditions: Post-Traumatic Stress Disorder
Interventions: BEHAVIORAL: standard|BEHAVIORAL: fixed|BEHAVIORAL: no focus|PROCEDURE: EMDR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Lurasidone for The Treatment of Schizophrenia or Schizoaffective Disorder in Subjects Switched From Other Antipsychotic Agents
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Lurasidone HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abciximab i.v. Versus i.c. in Primary PCI Patients With STEMI
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: Abciximab i.v.|DRUG: Abciximab i.c.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Breast Surgery in Treating Patients With Breast Cancer
Status: TERMINATED
Conditions: Male Breast Cancer|Recurrent Breast Cancer|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer
Interventions: PROCEDURE: endoscopic surgery|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT