pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Impact of Anti-TNF, Vedolizumab and Tofacitinib on Aortic Stiffness, Carotid Intima-media Thickness and Cardiovascular Risk of Patients With Ulcerative Colitis
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: OTHER: Aortic pulse wave velocity|OTHER: carotid intima media thickness (CIMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial
Status: COMPLETED
Conditions: HIV Infection|Vaginal Atrophy|Menopause|Menopause Related Conditions|Aging|Premature Aging|Atrophic Vaginitis|Dysbiosis|Vaginitis
Interventions: DRUG: Estradiol Vaginal Insert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Micro Electro Mechanical Systems to Detect the Air of Vaginal Discharge
Status: RECRUITING
Conditions: Vaginal Infection|Vaginitis
Interventions: DEVICE: Vaginal swab for RT-PCR|DEVICE: Vaginal swab for culture|DEVICE: Metabolic gas signatures detected by Ainos Flora (operated by participant)|DEVICE: Metabolic gas signatures detected by Ainos Flora (operated by medical staff)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Safety and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With Polatuzumab Vedotin in B-Cell Non-Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: B-cell Non-Hodgkin Lymphoma
Interventions: DRUG: Mosunetuzumab (IV)|DRUG: Mosunetuzumab (SC)|DRUG: Polatuzumab vedotin|DRUG: Tocilizumab|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Noninvasive Electrical Stimulation of Acupuncture Points (NESAP) Reduce Heelstick Pain in Infants?
Status: COMPLETED
Conditions: Pain
Interventions: DEVICE: NESAP|BEHAVIORAL: 24% oral Sucrose|DEVICE: Sham NESAP|BEHAVIORAL: Oral water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Recombinant EphB4-HSA Fusion Protein and Pembrolizumab, MK-3475
Status: ACTIVE_NOT_RECRUITING
Conditions: ALK Gene Mutation|BRAF Gene Mutation|EGFR Gene Mutation|Head and Neck Squamous Cell Carcinoma|Metastatic Head and Neck Carcinoma|Recurrent Head and Neck Carcinoma|Recurrent Non-Small Cell Lung Carcinoma|ROS1 Gene Mutation|Stage III Non-Small Cell Lung Cancer|Stage IIIA Non-Small Cell Lung Cancer|Stage IIIB Non-Small Cell Lung Cancer|Stage IV Non-Small Cell Lung Cancer
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab|BIOLOGICAL: Recombinant EphB4-HSA Fusion Protein
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnevist (SH L 451A) Intra-individual Dose Comparison Study in Magnetic Resonance Angiography
Status: COMPLETED
Conditions: Magnetic Resonance Angiography|Peripheral Vascular Diseases|Peripheral Arterial Diseases
Interventions: DRUG: Gadopentetate dimeglumine (Magnevist, BAY86-4882, SH L 451A)|DRUG: Gadopentetate dimeglumine (Magnevist, BAY86-4882, SH L 451A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trunk Muscle Training and Neuromuscular Electrical Stimulation to Improve Function in Older Adults With Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: BEHAVIORAL: Trunk Muscle Training+NMES|BEHAVIORAL: Passive control intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on the Efficacy and Safety of Qingre Heji in the Treatment of Acute Upper Respiratory Tract Infection
Status: COMPLETED
Conditions: Acute Upper Respiratory Tract Infection|Traditional Chinese Medicine|Randomised Controlled Trial
Interventions: DRUG: Qing Re He Ji|DRUG: Shuanghuanglian Oral Liquid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Leflunomide 20 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Leflunomide 20 mg Tablets|DRUG: ARAVA™ 20 mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Surgery With or Without Chemotherapy and Radiation Therapy in Treating Patients With Cancer of the Esophagus
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: cisplatin|DRUG: fluorouracil|PROCEDURE: surgical procedure|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Diffusing Alpha Radiation Therapy for Patients With Breast Carcinoma in Frail or Elderly Patients.
Status: RECRUITING
Conditions: Breast Cancer|Recurrent Breast Cancer|Breast Carcinoma
Interventions: DEVICE: Diffusing Alpha Radiation Emitters Therapy (DaRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Immunogenicity of GSK Biologicals' Pandemic Influenza (H1N1) Candidate Vaccine in Children
Status: TERMINATED
Conditions: Influenza
Interventions: BIOLOGICAL: GSK2340272A GSK Biologicals' investigational influenza pandemic vaccine|BIOLOGICAL: Infanrix™-IPV/Hib|BIOLOGICAL: Prevenar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessment of Treatment With PulseHaler on Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DEVICE: PulseHaler treatment|DEVICE: CPAP treatment (through a deactivated version of PulsHaler)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Meningococcal ACYWX Conjugate Vaccine, in 12-16 Month Olds
Status: COMPLETED
Conditions: Meningitis, Meningococcal
Interventions: BIOLOGICAL: Non-adjuvanted study formulation NmCV-5|BIOLOGICAL: Adjuvanted study formulation NmCV-5|BIOLOGICAL: Menactra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nipple Aspiration, Ductal Lavage, and Duct Endoscopy For Diagnostic Assessment in Women Undergoing Surgery for Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: GENETIC: cytogenetic analysis|GENETIC: proteomic profiling|OTHER: cytology specimen collection procedure|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|PROCEDURE: breast duct lavage
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: Randomized Multicenter Trial of Prehospital Initiated Facilitated Percutaneous Coronary Intervention (PCI) Versus Primary PCI in ST-segment-Elevation MI (STEMI)
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: fibrinolysis|PROCEDURE: Primary PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IV Lidocaine in Pediatric AIS
Status: ENROLLING_BY_INVITATION
Conditions: Systemic Lidocaine Improves Pain Control After Surgery by Attenuating the Systemic Inflammatory Response to Surgery
Interventions: DRUG: IV lidocaine|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ellagic Ácid on the Components of Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion
Status: UNKNOWN
Conditions: Metabolic Syndrome
Interventions: DRUG: Ellagic Acid / Pomegranate Extract|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide, Cyclophosphamide, and Dexamethasone in Treating Patients With Newly Diagnosed Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: cyclophosphamide|DRUG: dexamethasone|DRUG: lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Spinal Orthosis on the Development of Scoliosis and Chest Deformity in Type I Spinal Muscular Atrophy
Status: RECRUITING
Conditions: Spinal Muscular Atrophy Type I|Scoliosis|Chest Deformities|Spinal Orthosis|Pulmonary Rehabilitation|Exercise
Interventions: DEVICE: Thoracolumbosacral Spinal Orthosis (TLSO)|OTHER: Trunk Exercise (TE), Pulmonary Rehabilitation(PR) and Pulmonary Care (PC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of IGM-6268 in Healthy Adults and Patients With Mild to Moderate COVID-19
Status: TERMINATED
Conditions: Healthy Volunteers|COVID-19
Interventions: DRUG: IGM-6268|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sleep Disordered Breathing and Gestational Hypertension
Status: COMPLETED
Conditions: Sleep Disordered Breathing|Obstructive Sleep Apnea|Gestational Hypertension|Preeclampsia
Interventions: DEVICE: CPAP|DEVICE: Oral Appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Renal and Vascular Endstage Disease Intervention Trial
Status: COMPLETED
Conditions: Microalbuminuria|Cardiovascular Diseases|Renal Disease
Interventions: DRUG: Fosinopril|DRUG: Pravastatin|DRUG: Fosinopril Placebo|DRUG: Pravastatin Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Isotonic Beetroot Supplementation on Sprint Interval Exercise Performance
Status: RECRUITING
Conditions: Exercise Performance
Interventions: OTHER: Dietary Supplement: High nitrate isotonic drink|OTHER: Dietary Supplement: No nitrate isotonic drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Effects of Anaesthesia on Cerebral Oxygenation and Cognitive Function in Carotid Endarterectomy
Status: COMPLETED
Conditions: Endarterectomy|Postoperative Cognitive Dysfunction
Interventions: DRUG: Propofol|DRUG: Sevoflurane|PROCEDURE: Elective carotid endarterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Improving Physical Activity With Cognitive Impairment
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Caregiver Burnout
Interventions: BEHAVIORAL: Telerehabilitation physical activity behavioral (TPAB) intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: KAP for Depression in Abstinent Opioid Users
Status: TERMINATED
Conditions: Opioid Use Disorder, Severe, in Sustained Remission|Opioid Use Disorder, Severe, in Early Remission|Major Depressive Disorder
Interventions: DRUG: Ketamine-assisted psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Cognitive Remediation and Behavioral Intervention for Treatment of Attention-deficit/Hyperactivity Disorder (ADHD)
Status: UNKNOWN
Conditions: ADHD
Interventions: BEHAVIORAL: Cognitive remediation and Parent Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics Assessing Bioavailability of Gingerols and Shogaols of Five Ginger Extracts
Status: COMPLETED
Conditions: Healthy Subject
Interventions: DIETARY_SUPPLEMENT: Tested product n°1|DIETARY_SUPPLEMENT: Tested product n°2|DIETARY_SUPPLEMENT: Tested product n°3|DIETARY_SUPPLEMENT: Tested product n°4|DIETARY_SUPPLEMENT: Tested product n°5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ganciclovir by Infusion and by Mouth in Treating Patients With Cytomegalovirus After Donor Bone Marrow Transplant
Status: COMPLETED
Conditions: Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable|Leukemia|Lymphoma|Multiple Myeloma|MDS|Myelodysplastic/Myeloproliferative Diseases
Interventions: DRUG: Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Indomethacin Capsules to Treat Pain Following Bunionectomy
Status: COMPLETED
Conditions: Other Acute Postoperative Pain
Interventions: DRUG: Indomethacin|DRUG: Indomethacin|DRUG: Indomethacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS Tumors
Status: RECRUITING
Conditions: ALK Fusion-positive Solid or CNS Tumors
Interventions: DRUG: Alectinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Agonist Trigger With HCG Luteal Supplementation vs HCG Trigger With Progesterone Luteal Supplementation in Antagonist Controlled HyperstimulationCycle
Status: COMPLETED
Conditions: Infertility, Female
Interventions: DRUG: hCG|DRUG: Progesterone|DRUG: Triptorelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intravitreal Bevacizumab on Focal Edema With Hard Exudates Secondary to Diabetic Retinopathy
Status: UNKNOWN
Conditions: Diabetes Complications
Interventions: DRUG: Avastin (bevacizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cryoablation in Combination (or Not) With Pembrolizumab and Pemetrexed-carboplatin in 1st-line Treatment for Patients With Metastatic Lung Adenocarcinoma
Status: RECRUITING
Conditions: Lung Adenocarcinoma|Cryotherapy Effect
Interventions: DEVICE: Cryoablation|DRUG: Pembrolizumab|DRUG: Pemetrexed|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paraspinal Muscle Relaxation in Spine Surgery
Status: COMPLETED
Conditions: Paraspinal Muscle Relaxation in Spine Surgery
Interventions: DRUG: Anesthesia with non-depolarizing NMBA Rocuronium|DIAGNOSTIC_TEST: TOF measurement|DIAGNOSTIC_TEST: MEP measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: What Are we Missing? Diagnosing Uterine Adenomyosis Using Ultrasound Elastography
Status: COMPLETED
Conditions: Uterine Bleeding|Uterine Fibroids|Adenomyosis
Interventions: PROCEDURE: Evaluation of MRI, US for pelvic and uterine conditions|PROCEDURE: Patient preference between MRI and Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Single Center Study to Establish the Imaging Protocol of 99mTc-EC-DG in Evaluating the Presence and Severity of Coronary Artery Disease (CAD)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: RADIATION: Radiolabeled (99Tc) EC-DG (ethylenedicysteine-deoxyglucose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT
Status: RECRUITING
Conditions: Anaplastic Kidney Wilms Tumor|Recurrent Kidney Wilms Tumor|Stage II Kidney Wilms Tumor|Stage III Kidney Wilms Tumor|Stage IV Kidney Wilms Tumor
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Scan|DRUG: Carboplatin|PROCEDURE: Computed Tomography|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Etoposide|DRUG: Ifosfamide|DRUG: Irinotecan|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|RADIATION: Radiation Therapy|PROCEDURE: Surgical Procedure|DRUG: Topotecan|PROCEDURE: Transabdominal Ultrasound|DRUG: Vincristine|PROCEDURE: X-Ray Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peripheral Central Catheter (PICC) Care
Status: COMPLETED
Conditions: NEWBORN|Pain, Acute
Interventions: OTHER: Palmar grasp reflex stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment of Antioxidant Therapy on Oxidative Stress Biomarkers in Type 2 Diabetic Patients With Neuropathy
Status: COMPLETED
Conditions: Peripheral Diabetic Neuropathy
Interventions: DRUG: Resveratrol, Alpha lipoic acid, Super oxide dismutase|DRUG: Resveratrol|DRUG: Alpha lipoic acid|DRUG: Super Oxide Dismutase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety of Skin Cleansing With Chlorhexidine in Preterm Low Birth Weight Infants
Status: COMPLETED
Conditions: Neonatal Sepsis|Low Birth Weight
Interventions: DRUG: Chlorhexidine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Micro-excisional Skin Removal by Micro-coring Device in Treatment of Wrinkles and Laxity of Face and Neck
Status: COMPLETED
Conditions: Laxity; Skin
Interventions: DEVICE: HighThroughput Micro Coring Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect and Mechanism of Baitouweng Decoction for Large Intestine Damp-heat Syndrome of Ulcerative Colitis
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: Baitouweng Tang|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nuclectomy 3
Status: RECRUITING
Conditions: Back Pain With Radiation|Radiculopathy|Back Pain|Disc Herniation|Herniated Nucleus Pulposus|Herniated Disc|Disc Injury|Disk Herniated Lumbar
Interventions: DEVICE: PerQdisc Nucleus Replacement System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Observational Study to Evaluate the Effectiveness of Patisiran in Patients With Polyneuropathy of ATTRv Amyloidosis With a V122I or T60A Mutation
Status: COMPLETED
Conditions: Hereditary Transthyretin-mediated (ATTRv) Amyloidosis|Polyneuropathy
Interventions: DRUG: Patisiran
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Development of a Practical, Minimally Invasive Seizure Gauge
Status: COMPLETED
Conditions: Epilepsy
Interventions: DEVICE: EpiTel EpiLog|DEVICE: Byte Flies Sensor Dots|DEVICE: Empatica E4|DEVICE: Biovotion Everion|DEVICE: GeneActiv
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Attention Bias Modification, Attention Control and Psychoeducation for Irritability in Children and Adolescents
Status: COMPLETED
Conditions: Irritability
Interventions: OTHER: Attention bias modification training|OTHER: Attention Control Training|OTHER: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rapid Sequencing of Approved Therapies in Patients With Metastatic or Unresectable Clear Cell Renal Cell Carcinoma
Status: RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Cabozantinib|DRUG: Ipilimumab|DRUG: Nivolumab|DRUG: Lenvatinib|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of HH2710 in Patient With Advanced Tumors
Status: TERMINATED
Conditions: Advanced Tumors|Melanoma|Non-Small-Cell Lung Cancer|Erdheim-Chester Disease|Other RAS/RAF/MEK/ERK Mutated Tumors
Interventions: DRUG: HH2710
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lapatinib + Vinorelbine in ErbB2 Overexpressing, First or Second Line Metastatic Breast Cancer Subjects
Status: TERMINATED
Conditions: Neoplasms, Breast
Interventions: DRUG: Lapatinib, Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ALY688 Ophthalmic Solution in Subjects With Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: ALY688 Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Prophylactic Desmopressin on Blood Coagulation Parameters in Heart Valve Surgery
Status: UNKNOWN
Conditions: C.Surgical Procedure; Cardiac|Blood Coagulation Disorders
Interventions: DRUG: Desmopressin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Outcome Comparison of Two Total Knee Arthroplasty Systems: e.Motion-Pro Versus Genesis II
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: device: e.motion PS Pro|DEVICE: device : Genesis II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies
Status: NOT_YET_RECRUITING
Conditions: Rare Diseases|Aniridia|Neurotrophic Keratopathy|Limbal Stem Cell Deficiency|Ocular Graft-versus-host Disease|Ocular Cicatricial Pemphigoid|EEC Syndrome|Corneal Neovascularization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Controling Mean Arterial Pressure Using a Closed-Loop System for Vasopressor Titration
Status: COMPLETED
Conditions: Cardiac Surgery
Interventions: BEHAVIORAL: Computer guided vasopressor infusion|BEHAVIORAL: Manual control of vasopressor infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Field Implementation of iDETECT
Status: COMPLETED
Conditions: Concussion|Brain Trauma
Interventions: DEVICE: integrated Display Enhanced Testing for Cognitive Impairment and mild traumatic brain injury (iDETECT)|DEVICE: Riddell High Impact Technology (HIT) System|DEVICE: i1 Biometrics Vector Mouth Guard
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Precise Selection of Stent Diameter for Portal Hypertension Patients With TIPS
Status: ENROLLING_BY_INVITATION
Conditions: Compensated Advanced Chronic Liver Disease|Portal Hypertension
Interventions: OTHER: a non-invasive technology to evaluate hepatic venous pressure gradient and portal pressure gradient
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Postoperative Pain Relief With Transversus Thoracis Muscle Plane Block After Cardiac Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain, Postoperative|Anesthesia, Local|Coronary Artery Disease|Heart Valve Diseases
Interventions: DRUG: Placebo|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Olaparib in Patients With Metastatic Urothelial Cancer Harboring DNA Damage Response Gene Alterations
Status: COMPLETED
Conditions: Metastatic Urothelial Cancer
Interventions: DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Denervation in Patients With Recurrent Atrial Fibrillation After Successful Pulmonary Vein Isolation
Status: RECRUITING
Conditions: Arrhythmia Burden in Patients With Recurrent, Paroxysmal Atrial Fibrillation Despite Durable Pulmonary Vein Isolation
Interventions: DEVICE: Renal Denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Biodentine Versus Glass Ionomer Cement in Treatment of Very Deep Carious Lesions
Status: COMPLETED
Conditions: Deep Caries
Interventions: DRUG: biodentine|DRUG: glass ionomer cement|DEVICE: DigoraH optium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Xolair on Inhibiting Leukotriene and Cytokine (IL-4 and IL-13) Release From Blood Basophils
Status: UNKNOWN
Conditions: Allergy
Interventions: DRUG: Placebo|DRUG: Xolair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of Indocyanine Green During Pelvic Lymph Node Dissection in Prostate Cancer.
Status: UNKNOWN
Conditions: Prostate Cancer|Lymph Node Metastases
Interventions: DRUG: Indocyanine green
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cochlear Implantation in Single Sided Deafness and Asymmetrical Hearing Loss: a Cost/Utility Study.
Status: COMPLETED
Conditions: Retrocochlear Pathology|Auditory Processing Disorder, Central|Major Cochlear Ossification or Malformation
Interventions: DEVICE: cochlear implantation|OTHER: 6 months initial abstention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity of H. Influenzae Type b PRP-OMP Vaccines in American Indian and Alaska Native Children (the HibVax Study)
Status: COMPLETED
Conditions: Haemophilus Influenzae Type B Infection
Interventions: DRUG: Vaxelis|DRUG: PedvaxHIB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of BGB-10188 as Monotherapy, and in Combination With Zanubrutinib, and Tislelizumab
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|Follicular Lymphoma|Marginal Zone Lymphoma|Mantle Cell Lymphoma|Diffuse Large B Cell Lymphoma|Advanced Solid Tumor
Interventions: DRUG: BGB-10188|DRUG: Zanubrutinib|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Examining the PROMUS Element Everolimus-eluting Stent in Multi-center Coronary Intervention of Complex Arterial Lesion Subsets
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: platinum chromium everolimus-eluting stent (PROMUS Element by Boston Scientific, Massachusetts)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Dietary Advice in Primary Care to Promote Healthy Feeding of Infants
Status: WITHDRAWN
Conditions: Breast Feeding
Interventions: BEHAVIORAL: Ten Steps for Healthy Feeding children programme
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Combination Therapy With the MEK Inhibitor, Cobimetinib, Immune Checkpoint Blockade, Atezolizumab, and the AUTOphagy Inhibitor, Hydroxychloroquine in KRAS-mutated Advanced Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastrointestinal Cancer
Interventions: DRUG: Cobimetinib|DRUG: Hydroxychloroquine|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Au-Ag-Cu2O NG With PTT Anti Drug-resistant Microbial Keratitis
Status: UNKNOWN
Conditions: Keratitis, Ulcerative|Antibiotic Resistance, Microbial|Photothermal Therapy
Interventions: DRUG: Hollow gold and silver alloy cuprous oxide shell nano-shell hydrogel|DRUG: Voriconazole eye drops|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients
Status: NOT_YET_RECRUITING
Conditions: Respiratory Failure|Acute Hypoxemic Respiratory Failure|Acute Hypoxic Respiratory Failure|Hypoxemia|Hypoxia|Hypoxic Respiratory Failure
Interventions: OTHER: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Potassium-Magnesium Citrate as a Blood Pressure Lowering Agent in Hypertensive Patients
Status: WITHDRAWN
Conditions: Pre-hypertension|Hypertension
Interventions: DRUG: Potassium, Magnesium, Citrate|DRUG: Potassium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Use of Streptokinase for Enhancement of Percutaneous Drainage of Pancreatic Necrosis
Status: COMPLETED
Conditions: Acute Pancreatitis
Interventions: DRUG: streptokinase|OTHER: Saline irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Intensification Study in Refractory Germ Cell Tumors With Relapse and Bad Prognosis
Status: COMPLETED
Conditions: Germ Cell Tumors
Interventions: DRUG: Paclitaxel|DRUG: Ifosfamide|DRUG: Carboplatine|DRUG: Etoposide|PROCEDURE: cytapheresis + transfusion of autologous peripheral blood stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neutrophil Extracellular Traps in Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus|Systemic Sclerosis
Interventions: OTHER: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Yakult Ingestion on Diet-induced Insulin Resistance in Humans
Status: COMPLETED
Conditions: Insulin Sensitivity|Insulin Resistance|Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Yakult light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fulvestrant With or Without AZD6244 in Treating Patients With Advanced Breast Cancer That Progressed After Aromatase Inhibitor Therapy
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: fulvestrant|DRUG: selumetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Verify the Efficacy and Safety of Rapamycin Coated Peripheral Balloon Catheter in the Treatment of Femoral Popliteal Artery Disease
Status: NOT_YET_RECRUITING
Conditions: Peripheral Arterial Disease
Interventions: PROCEDURE: Percutaneous selective arteriography of peripheral arteries|PROCEDURE: Percutaneous selective arteriography of peripheral arteries
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Mictalase® After ThuLEP
Status: COMPLETED
Conditions: BPH With Urinary Obstruction With Other Lower Urinary Tract Symptoms
Interventions: DEVICE: Phenolmicin P3 and Bosexil suppository
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of DRS-R-98 and 3D-CAM in the Assessment of Postoperative Delirium in Elderly Patients
Status: COMPLETED
Conditions: Postoperative Delirium
Interventions: DIAGNOSTIC_TEST: comparing DRS-R-98 (The Delirium Rating Scale--Revised-98) and 3D-CAM (3-minute diagnostic assessment for CAM-Confusion Assessment Method-defined delirium) tests to assess postoperative delirium
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Development and Prospective Validation of a Standardized Flow Cytometric Assay of Peripheral Blood Neutrophil Myeloperoxidase Expression for Ruling Out Myelodysplastic Syndromes.
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelodysplastic Syndromes
Interventions: OTHER: Diagnostic Test: Flow cytometry analysis of neutrophil myeloperoxidase expression
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Evaluation of Approved and Investigational Contact Lenses Using New UV Additive
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: senofilcon A with new UV blocker|DEVICE: senofilcon A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vorinostat and Lenalidomide After Autologous Stem Cell Transplant in Treating Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma|Plasma Cell Neoplasm
Interventions: DRUG: lenalidomide|DRUG: vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iloperidone for Symptoms of Arousal in Post Traumatic Stress Disorder (PTSD)
Status: TERMINATED
Conditions: Post Traumatic Stress Disorder
Interventions: DRUG: Iloperidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: De-escalation Protocols in Locoregionally Advanced Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: RADIATION: Toxicities reduced treatment|RADIATION: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imaging in Moyamoya Disease - Study to Investigate Different Imaging Technologies for a Better Understanding of Various Imaging Techniques to Evaluate Cerebral Hemodynamics, Disease-activity and Possibly the Etiology in Moyamoya Patients
Status: NOT_YET_RECRUITING
Conditions: Moyamoya Disease|Moyamoya
Interventions: DIAGNOSTIC_TEST: MRI|DIAGNOSTIC_TEST: H2 15O PET/CT|OTHER: Biosampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Shortening the Palatal Extension of the Mouthguard on the Degree of Satisfaction of Water Polo Players
Status: COMPLETED
Conditions: Mouth Protectors|Quality of Life
Interventions: DEVICE: Use of conventional mouthguard|DEVICE: Use of shortened mouthguard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase II Study of Carelizumab Combined With Irinotecan and Apatinib of Second-line Treatment for Advanced Gastric Cancer
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Carelizumab Combined With Irinotecan and Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HostDx Sepsis in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections and Suspected Sepsis
Status: RECRUITING
Conditions: Respiratory Tract Infections|Urinary Tract Infections|Intra-Abdominal Infections|Skin and Soft Tissue Infection|Suspected Meningitis/Encephalitis or Any Other Infection|Sepsis
Interventions: DIAGNOSTIC_TEST: HostDx Sepsis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Analgesic Efficacy of Repeated Doses of Intravenous (IV) Acetaminophen in Post-operative Pediatric Spine Fusion Patients
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Intravenous Acetaminophen|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Inflammatory Bowel Diseases in Persons at Risk The PIONIR (Preventing IBD Onset in Individuals at Risk) Trial
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases
Interventions: OTHER: Tasty&Healthy|OTHER: Habitual diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: An Investigation on the Effects of Icosapent Ethyl (VascepaTM) on Inflammatory Biomarkers in Individuals With COVID-19
Status: COMPLETED
Conditions: COVID-19|Inflammatory Response
Interventions: DRUG: Icosapent ethyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of DOX-SL Versus Adriamycin Plus Bleomycin Plus Vincristine in the Treatment of Severe AIDS-Related Kaposi's Sarcoma
Status: UNKNOWN
Conditions: Sarcoma, Kaposi|HIV Infections
Interventions: DRUG: Doxorubicin hydrochloride (liposomal)|DRUG: Bleomycin sulfate|DRUG: Vincristine sulfate|DRUG: Doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of Two Different Dose Combinations of Nivolumab in Combination With Ipilimumab in Subjects With Previously Untreated, Unresectable or Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: Nivolumab 3 mg/kg IV|BIOLOGICAL: Ipilimumab 1 mg/kg IV|BIOLOGICAL: Nivolumab 1 mg/kg IV|BIOLOGICAL: Ipilimumab 3 mg/kg IV|BIOLOGICAL: Nivolumab 6 mg/kg IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Montelukast Post-marketing Comparative Study With Theophyline Added to Inhaled Corticosteroid (0476-396)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: montelukast|DRUG: Theophylline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Liraglutide on Blood Glucose Control in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: glibenclamide|DRUG: placebo|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quality of Life Measurement in Treatment Naïve Patients With Hepatitis C Virus (HCV) Genotype 1 (GT1) Suffering From Fatigue and Receiving Ombitasvir, Paritaprevir, and Ritonavir and Dasabuvir (Viekirax®/Exviera®)
Status: COMPLETED
Conditions: Chronic Hepatitis C Virus (HCV)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Burden of Primary Caregivers of Spinal Muscular Atrophy Patients and Their Needs
Status: COMPLETED
Conditions: Spinal Muscular Atrophy|Caregiver Burden
Interventions: BEHAVIORAL: Zarit Burden Interview Scale|BEHAVIORAL: Family Needs Survey (FNS)|OTHER: Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND)|OTHER: Hammersmith Functional Motor Scale Expanded (HMFSE)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Efficacy and Safety of Brivaracetam as Treatment for Increased Seizure Activity in an Epilepsy Monitoring Unit Setting
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Brivaracetam|DRUG: Lorazepam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Effectiveness of RCHOP With or Without VELCADE in Previously Untreated Non-Germinal Center B-Cell-like Diffuse Large B-Cell Lymphoma Patients
Status: COMPLETED
Conditions: Non-Germinal B-Cell-like (GCB) Diffuse Large B-cell Lymphoma (DLBCL)
Interventions: DRUG: Bortezomib|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REEDUCATION OF OLFACTORY DISORDERS AFTER A CEREBRAL VASCULAR ACCIDENT IN ADULTS
Status: UNKNOWN
Conditions: Adult With Stroke and Olfaction's Complaint
Interventions: OTHER: olfactory rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral Phloroglucin (Flospan®) as Premedication of Non-sedative Diagnostic Esophagogastroduodenoscopy
Status: COMPLETED
Conditions: Anti-spasmodics|Gastric Peristalsis|Non-sedative Endoscopy
Interventions: DRUG: Phloroglucin(Flospan®)|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Biomechanical Properties of the Wall of an Aneurysmal-altered Abdominal Aorta According to the Results of in Vivo Ultrasound and an Associated Study of Strength Characteristics in Vitro
Status: NOT_YET_RECRUITING
Conditions: the Strength Properties of the Aorta in Vivo|the Strength Properties of the Aorta in Vitro|Regression Model of Aortic Strength Properties in Vitro and in Vitro
Interventions: DIAGNOSTIC_TEST: aneurysmectomy with sampling of a segment of the aneurysm wall
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of NeuroVax™, a Novel Therapeutic TCR Peptide Vaccine for Pediatric Multiple Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis
Interventions: BIOLOGICAL: NeuroVax|BIOLOGICAL: IFA Incomplete Freund's Adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Inversion and Fixation of the Transversalis Fascia in Laparoscopic Inguinal Hernia Repair
Status: UNKNOWN
Conditions: Hernia, Inguinal
Interventions: PROCEDURE: Transversalis Fascia Inversion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Type 1 Interferon Induced Changes to Exercise Adaptations in Systemic Lupus Erythematosus Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Systemic Lupus Erythematosus|Interferon Deficiency
Interventions: BEHAVIORAL: High Intensity Interval Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Forced-air Warming in Endovascular Surgery: Testing Effectiveness of Two Different Blanket Models
Status: COMPLETED
Conditions: Hypothermia
Interventions: DEVICE: Upper body blanket, Bair Hugger|DEVICE: Underbody blanket, Bair Hugger
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Post-lobectomy Use of Glucose for Pleurodesis and Air-leak Cessation. A Feasibility Trial.
Status: COMPLETED
Conditions: Pulmonary Surgical Procedures
Interventions: DRUG: Hypertonic 50% dextrose pleurodesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ESPB vs iPACK+ACB in Total Knee Arthroplasty
Status: NOT_YET_RECRUITING
Conditions: Knee Arthritis|Knee Arthropathy|Knee Osteoarthritis|Knee Pain Chronic|Knee Disease|Knee Rheumatism
Interventions: DRUG: Ropivacaine 0.2% Injectable Solution|DRUG: Ropivacaine 0.2% Injectable Solution|DRUG: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab Every 12 Weeks Versus Every 3 Weeks in Treating Patients With Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Non-Small Cell Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT