pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Histamine H2 Antagonism as Adjuvant Therapy in Treatment Resistant Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: famotidine|DRUG: Placebo (Microcrystallized cellulose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Salivary Alpha-amylase as a Predictor of Delirium After Lower Extremity Vascular Bypass Surgery
Status: NOT_YET_RECRUITING
Conditions: Salivary Alpha-amylase|Delirium|Lower Extremity|Vascular Bypass Surgery
Interventions: DIAGNOSTIC_TEST: Salivary Alpha-amylase
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use of APX 100 Device for Small-pupil Cataract Surgery and Intraoperative Floppy-iris Syndrome
Status: COMPLETED
Conditions: Miosis Disorder|Intraoperative Floppy Iris Syndrome
Interventions: DEVICE: Pupil expansion with APX 100 device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Substituting Sitting With Standing and Light Intensity Activity in Free-living Conditions on Glycaemia in Overweight and Obese South Asian Adults
Status: UNKNOWN
Conditions: Cardiovascular Risk Factor|Cardiovascular Diseases|Diabetes|Type 2 Diabetes|Sedentary Behavior|Sedentary Lifestyle
Interventions: OTHER: Sit regimen|OTHER: SitLess regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lot-to-lot Consistency of Tritanrix™-HepB/Hib-MenAC & Its Non-inferiority vs Tritanrix™-HepB/Hiberix™ in Infants
Status: COMPLETED
Conditions: Tetanus|Hepatitis B|Haemophilus Influenzae Type b|Whole Cell Pertussis|Diphtheria
Interventions: BIOLOGICAL: Hib-MenAC mixed with Tritanrix™-HepB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: Metabolic Syndrome and Functional Food
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: P1&P2|DIETARY_SUPPLEMENT: P1&CC|DIETARY_SUPPLEMENT: AG&P2|DIETARY_SUPPLEMENT: AG&CC|DIETARY_SUPPLEMENT: TA (concentrated 5:1 aloe vera gel)|DIETARY_SUPPLEMENT: P3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial of E Cigarettes in Pts Diagnosed With Cancer of the Head, Neck, and Lung
Status: WITHDRAWN
Conditions: Head and Neck Squamous Cell Carcinoma|Lung Non-Small Cell Carcinoma|Stage I Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8|Stage I Lung Cancer AJCC v8|Stage IA1 Lung Cancer AJCC v8|Stage IA2 Lung Cancer AJCC v8|Stage IA3 Lung Cancer AJCC v8|Stage IB Lung Cancer AJCC v8|Stage II Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8|Stage II Lung Cancer AJCC v8|Stage IIA Lung Cancer AJCC v8|Stage IIB Lung Cancer AJCC v8|Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8|Stage III Lung Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8|Stage IIIB Lung Cancer AJCC v8|Stage IIIC Lung Cancer AJCC v8|Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8
Interventions: OTHER: Best Practice|DRUG: Nicotine Replacement|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Post-Marketing Safety Study Following Long-Term Prophylactic OptivateTreatment in Subjects With Severe Haemophilia A
Status: TERMINATED
Conditions: Haemophilia A
Interventions: BIOLOGICAL: Optivate 500IU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Chloroquine + Sulfadoxine Pyrimethamine Versus Artemether + Lumefantrine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria in the Philippines
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: artemether/lumafantrine vs chloroquine/sulfadoxine-pyrimethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Propofol, Propofol-remifentanil and Propofol-ketamine Anesthesia During Electroconvulsive Therapy
Status: COMPLETED
Conditions: Anesthesia|Electroconvulsive Therapy
Interventions: DRUG: Propofol|DRUG: Propofol+Remifentanil|DRUG: Propofol+Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating an mHealth Intervention for Reducing Alcohol Use Among Rural Adolescent and Young Adult Cancer Survivors
Status: COMPLETED
Conditions: Cancer|Alcohol Use
Interventions: BEHAVIORAL: TRAC: Tracking and Reducing Alcohol Consumption|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Effect of Acupuncture for Advanced Cancer Patients With Palliative Care: a Three-arm Randomized Trial
Status: UNKNOWN
Conditions: Advanced Cancer
Interventions: OTHER: Acupuncture and standard care (ASC)|OTHER: Sham acupuncture and standard care (SSC)|OTHER: Standard care (SC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prospective Database of Factors Associated With Faecal vs. Double Incontinence in Patients Referred for High Resolution Anorectal Manometry.
Status: RECRUITING
Conditions: Double Incontinence|Faecal Incontinence|Urinary Incontinence
Interventions: OTHER: Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Local Infiltration Analgesia Following Total Knee Arthroplasty
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: ropivacaine, ketorolac and epinephrine|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study in Current Medical Practice of the Efficacy and Safety of Ranibizumab 0.5mg in Diabetic Patients Presenting a Visual Impairment Due to Macular Edema
Status: COMPLETED
Conditions: Visual Impairment|Macular Edema
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Critically Ill Patients Investigating Tolerability and Efficacy of Low-volume Pharmaconutrition (Intestamin)
Status: COMPLETED
Conditions: Critical Illness|Adult|Sepsis|Systemic Inflammatory Response Syndrome
Interventions: DIETARY_SUPPLEMENT: Fresubin Original|DIETARY_SUPPLEMENT: Intestamin plus Fresubin Original
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Early Warning of Delayed Cerebral Ischemia
Status: RECRUITING
Conditions: Subarachnoid Hemorrhage, Aneurysmal|Vasospasm, Cerebral|Ischemia|Outcome, Fatal
Interventions: RADIATION: Computed Tomography (CT) and Computed Tomography Angiography (CTA)|DIAGNOSTIC_TEST: Multimodal physiological monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of a Dengue-1-Virus-Live Virus Human Challenge - (DENV-1-LVHC) Virus Strain
Status: COMPLETED
Conditions: Dengue
Interventions: BIOLOGICAL: Dengue-1 Virus-Live Virus Human Challenge (DENV-1-LVHC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Enhancing Memory in CPT for PTSD
Status: NOT_YET_RECRUITING
Conditions: Stress Disorders, Post-Traumatic
Interventions: BEHAVIORAL: Cognitive Processing Therapy|BEHAVIORAL: Cognitive Processing Therapy (CPT) + Memory Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ridaforolimus in Non-Small Cell Lung Cancer (NSCLC) Patients With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutations (MK-8669-021 AM1)
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Lead-In Ridaforolimus|DRUG: Comparator: Blinded Ridaforolimus|DRUG: Comparator: Blinded Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GWICTIC: NAC Mechanistic Study in Gulf War Veterans
Status: RECRUITING
Conditions: Gulf War Syndrome
Interventions: DRUG: N-Acetyl Cysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Whole-body Hyperthermia for Mild to Moderate Depressive Disorder
Status: COMPLETED
Conditions: Depression, Unipolar
Interventions: DEVICE: Whole-body hyperthermia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Splenic Flexure Mobilization
Status: COMPLETED
Conditions: Splenic Flexure Mobilization
Interventions: PROCEDURE: Laparoscopic high anterior resection splenic flexure mobilization|PROCEDURE: Laparoscopic high anterior resection without splenic flexure mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study Evaluating the Role of Androgen Receptors as Targets for Therapy of Pre-treated Post-menopausal Patients With ER/PgR-negative/AR-positive or ER and/or PgRpositive/ AR-positive Metastatic Breast Cancer (ARTT)
Status: TERMINATED
Conditions: Metastatic Breastcancer|Estrogen Receptor Positive Breast Cancer|Estrogen Receptor Negative Neoplasm|Progesterone Receptor Positive Tumor|Progesterone Receptor Negative Neoplasm|Androgen Receptor Gene Overexpression
Interventions: DRUG: DHEA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Caffeine Injection as an Adjuvant to Opioid Therapy in Cancer Pain
Status: COMPLETED
Conditions: Cancer|Pain
Interventions: DRUG: Caffeine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Identification of Fatty Liver With Advanced Fibrosis in Type 2 Diabetes Using Simple Fibrosis Scores and Electronic Reminder Messages
Status: COMPLETED
Conditions: Fatty Liver, Nonalcoholic|Diabetes Mellitus, Type 2
Interventions: DIAGNOSTIC_TEST: Simple fibrosis scores and electronic reminder messages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Live Stream of Prehospital point-of Care Ultrasound During Cardiopulmonary Resuscitation
Status: COMPLETED
Conditions: Cardiopulmonary Resuscitation|Echocardiography|Ultrasound
Interventions: OTHER: Point-of-care ultrasound with tele-supervision
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Once Daily Long-Acting Muscarinic Antagonists Administered in the Evening for Prevention of Chronic Obstructive Pulmonary Disease Exacerbations Requiring Hospitalization or Death From Any Cause
Status: RECRUITING
Conditions: COPD Exacerbation
Interventions: DRUG: Long acting muscarinic antagonists (LAMAs) in the evening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra Articular Injection of Microfat and PRP in Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: Autologous biologic drug of innovative therapy /cell therapy drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BMS-354825 or Imatinib Mesylate in Treating Patients With Chronic Phase Chronic Myelogenous Leukemia That Did Not Respond to Previous Imatinib Mesylate
Status: UNKNOWN
Conditions: Leukemia
Interventions: DRUG: dasatinib|DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IPH5201 as Monotherapy or in Combination With Durvalumab +/- Oleclumab in Subjects With Advanced Solid Tumors.
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: BIOLOGICAL: IPH5201|BIOLOGICAL: durvalumab|BIOLOGICAL: oleclumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management and Coaching in Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: BEHAVIORAL: A cognitive behavior therapy distress management program targeting wellbeing in patients with atrial fibrillation and their relatives
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gemcitabine and Oxaliplatin in the Management of Metastatic Pancreatic Cancers With Low Expression of ERCC1
Status: WITHDRAWN
Conditions: Metastatic Pancreatic Cancer|ERCC1
Interventions: DRUG: gemcitabine and oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Canola Oil on Blood Vessel Function in Peripheral Arterial Disease
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: OTHER: traditional canola oil|OTHER: high oleic canola oil|OTHER: soybean oil|OTHER: high linoleic safflower oil|OTHER: coconut oil|OTHER: traditional canola oil|OTHER: safflower oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Study to Compare the Pharmacokinetics of CSL312 Administered by Prefilled Syringe Assembled to Autoinjector to the Pharmacokinetics Administered by Prefilled Syringe Assembled to Needle Safety Device in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: CSL312
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Randomized Comparison of Optimal Medical Therapy and Percutaneous Recanalization for Chronic Total Occlusion (COMET-CTO)
Status: COMPLETED
Conditions: Chronic Total Occlusions of Coronary Arteries
Interventions: PROCEDURE: Percutaneous coronary intervention|DRUG: Optimal medical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Analgesic Efficacy and Safety of ADL5859 in Participants With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: ADL5859|DRUG: Naproxen|DRUG: Placebo|DRUG: ADL5859|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Using Projector Kaleidoscope and Matching Card on Children's Fear and Physiological Parameters
Status: COMPLETED
Conditions: Fear|Child, Only|Respiratory Disease
Interventions: OTHER: Projector colleyscope group|OTHER: Matching card group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: CRP and PCT as Predictors of Sepsis Cause
Status: COMPLETED
Conditions: Sepsis|Gram-Positive Bacteremia|Gram-negative Bacteremia
Interventions: DIAGNOSTIC_TEST: PCT levels|DIAGNOSTIC_TEST: CRP levels|DIAGNOSTIC_TEST: White blood cell count|DIAGNOSTIC_TEST: Platelet count
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Duchenne Muscular Dystrophy Clinical Trial
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: DEVICE: VECTTOR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Sex-Related HIV Risk Behaviors in Patients Receiving Treatment for Opioid Dependence
Status: COMPLETED
Conditions: Opiate Dependence|HIV Infections
Interventions: BEHAVIORAL: Enhanced Sexual Risk Management|BEHAVIORAL: Standard Sexual Risk Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-SURGerY High-resolution Specimen PET/CT Imager for Margin Assessment in Early-stage Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Breast-conserving Surgery
Interventions: DEVICE: AURA 10 PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparing the Efficacy of Oral Opioids for Outpatient Acute Pain Management After ED Discharge Discharge
Status: COMPLETED
Conditions: Analgesia After ED Discharge for Extremity Injuries
Interventions: DRUG: Hydrocodone (first trial)|DRUG: Codeine (first trial)|DRUG: Oxycodone (for second trial)|DRUG: Codeine (for second trial)|DRUG: Oxycodone (third trial)|DRUG: Hydrocodone (third trial)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Immunologic Response Following COVID-19 Vaccination in Children, Adolescents, and Young Adults With Cancer
Status: RECRUITING
Conditions: COVID-19 Infection|Hematopoietic and Lymphatic System Neoplasm|Malignant Solid Neoplasm
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Survey Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neuroinflammation and Neurodegeneration in HIV-positive Subjects Switched and Initially Treated With INSTI
Status: UNKNOWN
Conditions: HIV I Infection|HIV Associated Lipodystrophy|Metabolic Syndrome|Aging
Interventions: DIAGNOSTIC_TEST: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Safety and Dose Finding Study of Plasmin (Human) Administered Into the Middle Cerebral Artery of Stroke Patients
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: BIOLOGICAL: Plasmin (Human)|BIOLOGICAL: Plasmin (Human)|BIOLOGICAL: Plasmin (Human)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Air Barrier System for the Reduction of Airborne Colony-forming Units During Total Shoulder Arthroplasty
Status: UNKNOWN
Conditions: Osteo Arthritis Shoulders
Interventions: DEVICE: Control|DEVICE: Air Barrier System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Depth of Necrosis in Normal Cervical Epithelium After 85% Trichloroacetic Acid (TCA) Application
Status: COMPLETED
Conditions: Cervix; Intraepithelial Neoplasia
Interventions: DRUG: 85% TCA Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TRADE-Testosterone Replacement and Dutasteride Effectiveness
Status: COMPLETED
Conditions: Hypogonadism|Benign Prostatic Hyperplasia
Interventions: DRUG: Dutasteride|DRUG: Testosterone gel|DRUG: Placebo dutasteride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Topical NSAID to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions.
Status: COMPLETED
Conditions: Oral Lichen Planus|Oral Lichenoid Mucositis|Oral Lichenoid Reaction
Interventions: DRUG: Ibuprofen suspension 5mg/100ml|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Do Omega-3 Fatty Acids Have an Antidepressant Effect in Patients With Signs of Peripheral Inflammation?
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DIETARY_SUPPLEMENT: Eicosapentaenoic acid enriched omega-3 fatty acids, 2 g/day
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colesevelam for Children With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: High-dose colesevelam|DRUG: Low-dose colesevelam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Idelalisib in Combination With Obinutuzumab Compared to Chlorambucil in Combination With Obinutuzumab for Previously Untreated Chronic Lymphocytic Leukemia
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Idelalisib|DRUG: Chlorambucil|DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Efficacy and the Safety of First-line Chemotherapy Combined With the Therapeutic Vaccine Named TG4010 and Nivolumab in Patients With Advanced Non-squamous Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer Metastatic
Interventions: BIOLOGICAL: TG4010|DRUG: Chemotherapy|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Adding Azithromycin to Cephalosporin Before Cesarean Delivery
Status: COMPLETED
Conditions: Wound Sepsis
Interventions: DRUG: cephalosporin|DRUG: Azithromycin Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Computer-delivered Psychosocial Intervention for Adolescent Substance Use Disorders
Status: UNKNOWN
Conditions: Substance-Related Disorders|Alcohol-Related Disorders|Marijuana Abuse
Interventions: BEHAVIORAL: Usual care|BEHAVIORAL: Computer-delivered ACRA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Roflumilast Taken in the Morning or Evening in Patients With Stable Asthma (12 to 70 y) (BY217/M2-015)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Roflumilast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Elranatamab|DRUG: Elotuzumab|DRUG: Pomalidomide|DRUG: Dexamethasone|DRUG: Bortezomib|DRUG: Carfilzomib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention to Improve Quality of Life in African American Lupus Patients
Status: COMPLETED
Conditions: Depression|Systemic Lupus Erythematosus
Interventions: BEHAVIORAL: Chronic Disease Self-Management Program (CDSMP)|BEHAVIORAL: Mail-delivered arthritis kit|BEHAVIORAL: Support group|BEHAVIORAL: Listserv
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Therapeutic Omegas for Triglyceride Suppression
Status: RECRUITING
Conditions: Pregnancy
Interventions: DIETARY_SUPPLEMENT: Intervention Omega 3 Supplementation|DIETARY_SUPPLEMENT: Control Safflower Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Protection From Acute Kidney Injury (AKI) With Basis™ Treatment
Status: COMPLETED
Conditions: AKI
Interventions: DRUG: Nicotinamide Riboside + Pterostilbene|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Randomized Controlled Trial of Human Papillomavirus Testing in Primary Cervical Cancer Screening
Status: COMPLETED
Conditions: Cervical Cancer|Cervical Intraepithelial Neoplasia
Interventions: PROCEDURE: Adding Human Papillomavirus testing to organised cervical screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: SCREENING
Clinical trial: Ethanol Sclerotherapy Prior to ART
Status: RECRUITING
Conditions: Endometrioma|Infertility|Sclerotherapy|ART|IVF
Interventions: PROCEDURE: Ethanol Sclerotherapy for Endometrioma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on the Effect of Selenium Yeast Capsule on Prognosis of Differentiated Thyroid Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Selenium Deficiency|Thyroid Cancer TNM Staging|Recurrence|Metastasis
Interventions: DRUG: Selenium Yeast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Deep Brain Stimulation (DBS) for Obsessive Compulsive Disorder (OCD): Improving Targeting Precision
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: PROCEDURE: Micro-assisted technique|PROCEDURE: Standard technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MR(Magnetic Resonance) Imaging of Neurotransmitters in Chronic Pain
Status: TERMINATED
Conditions: Chronic Low Back Pain|Diabetic Peripheral Neuropathy|Knee Osteoarthritis
Interventions: OTHER: MRIs|OTHER: Pain testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pre-operative Chemo (CPT11, Cisplatin), Radiotherapy, Plus Surgery for Resectable Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: Irinotecan hydrochloride trihydrate|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Transmission of Hepatitis C Virus (HCV) From HCV-Viremic Organ Donor
Status: COMPLETED
Conditions: Hepatitis C|Hepatitis C Virus Infection, Response to Therapy of
Interventions: DRUG: glecaprevir/pibrentasvir (GLE/PIB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Safety and Biomarker Study of ALZT-OP1a in Subjects With Mild-Moderate ALS Disease
Status: TERMINATED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: ALZT-OP1a (cromolyn)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Robotic Assisted Surgery for Treatment of Gynecological Diseases: Pilot Study
Status: COMPLETED
Conditions: Adnexal Diseases|Uterine Diseases
Interventions: DEVICE: TELELAP ALF-X Robotic Surgical System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Different Formulations of Telmisartan, Amlodipine, and Hydrochlorothiazide (HCTZ) in Japanese Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Telmisartan/Amlodipine|DRUG: Telmisartan/Amlodipine/HCTZ|DRUG: Telmisartan/HCTZ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamfetamine Sulphate in Patients With Glioma Suffering From Severe Asthenia
Status: UNKNOWN
Conditions: Glioma
Interventions: DRUG: Dexamfetamine sulphate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation and and Glycemic Indexes
Status: COMPLETED
Conditions: Deficiency, Vitamin D|Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: cholecalciferol (Euro-Pharm International, Canada)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Split-course Chemoradiotherapy For Postoperative Locoregional Recurrence Of Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: RADIATION: split-course radiotherapy|DRUG: concurrent chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing Combination Therapy of Acetaminophen Plus Ibuprofen Versus Tylenol #3 for the Treatment of Pain After Outpatient Surgery
Status: COMPLETED
Conditions: Laparoscopic Cholecystectomy|Inguinal Hernia|Abdominal Hernia|Umbilical Hernia
Interventions: DRUG: Tylenol #3|DRUG: Combination Tylenol and Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Stress and HIV-related Stigma Among Men in Viet Nam
Status: RECRUITING
Conditions: Bisexuality|Homosexuality|HIV Infections
Interventions: BEHAVIORAL: "Vina-STEAM" (Skills to Empower Affirmative Men)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Value of Preoperative Dynamic Lymphscintigraphy and Ultrasoundscanning, Eventually With FNA, for Identification of Malignant Sentinel Node(s) in Patients With Melanoma
Status: UNKNOWN
Conditions: Melanoma
Interventions: PROCEDURE: FNA (fine needle aspiration)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Palliative Care Intervention in Improving Quality of Life, Psychological Distress, and Communication in Patients With Solid Tumors Receiving Treatment
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: OTHER: palliative care|OTHER: palliative care|PROCEDURE: quality-of-life assessment|OTHER: survey administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vitamin D Supplementation and Muscle Characteristics in Trained Subjects
Status: COMPLETED
Conditions: Healthy Subjects, Trained
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Neratinib for Treatment and Prevention of Subsequent CNS Event(s) in Patients With Brain Metastasis of Advanced HER2 Positive Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer|Brain Metastases
Interventions: DRUG: Neratinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study to Evaluate LDL-C Lowering Effect of Ezetimibe (0653-070)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: MK0653, ezetimibe / Duration of Treatment: 4 Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy of Phenol Block and Corticosteroid-Local Anesthetic Block Applied to the Genicular Nerve
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DRUG: Phenol|DRUG: Celestone|DRUG: Lidocain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Rehabilitation in Non Cystic Fibrosis Bronchiectasis
Status: COMPLETED
Conditions: Bronchiectasis
Interventions: PROCEDURE: Chest physiotherapy|PROCEDURE: Chest Physiotherapy + Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Double-blind, Placebo-controlled, Randomized Study of the Effectiveness of Escitalopram on Emotional Distress of Head and Neck Cancer Patients During Cancer Treatment
Status: UNKNOWN
Conditions: Carcinomas
Interventions: DRUG: Escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Acute Trans-resveratrol Administration on Whole Body Metabolism During Cognitive Demand.
Status: COMPLETED
Conditions: Cognitive Change
Interventions: DIETARY_SUPPLEMENT: Resveratrol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ontario Printed Educational Materials (PEMs) for Physician Behaviour Change
Status: UNKNOWN
Conditions: Education, Medical, Continuing|Practice Patterns|Hypertension|Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Printed Educational Message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Edoxaban Treatment Versus Vitamin K Antagonist in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Edoxaban|DRUG: Clopidogrel|DRUG: Prasugrel|DRUG: Ticagrelor|DRUG: Vitamin K antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Treatment for Chronic Rhinosinusitis With Nasal Polyposis
Status: NOT_YET_RECRUITING
Conditions: Chronic Rhinosinusitis|Nasal Polyps
Interventions: DRUG: Triamcinolone-impregnated CMC foam|DEVICE: Propel Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Meta-analyses of Impotrant Food Sources of Sugars and Incident Cardiometabolic Diseases
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Metabolic Syndrome X|Hypertension|Cardiovascular Diseases|Stroke|Gout
Interventions: OTHER: Fructose-containing Sugars
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: LISA Rigid Catheter vs LISA Soft Catheter in a Very Preterm Manikin
Status: COMPLETED
Conditions: Respiratory Distress Syndrome in Preterm Infants
Interventions: DEVICE: Rigid catheter|DEVICE: Soft catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fertilizations With Immotile Sperm: Pentoxyphylline Activation Alone, or With Chemical Oocyte Activation
Status: WITHDRAWN
Conditions: Infertility
Interventions: BIOLOGICAL: PXN sperm treatment|BIOLOGICAL: Sperm activation with PXN and oocyte activation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Above-versus Below-elbow Casting for Conservative Treatment of Distal Radius Fractures
Status: COMPLETED
Conditions: Distal Radius Fracture
Interventions: DEVICE: Below elbow immobilization|DEVICE: Above elbow immobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COmparison of Clarus and Optos Ultrawide Field Imaging Systems for Inherited Retinal Disease
Status: RECRUITING
Conditions: Retinal Disease
Interventions: DEVICE: Spectralis FAF imaging|DEVICE: Optos imaging|DEVICE: Clarus imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Cerebral-Coronary Connection (C3) Study
Status: UNKNOWN
Conditions: Ischemic Heart Disease|Microvascular Coronary Artery Disease|Depression|Endothelial Dysfunction|Inflammation
Interventions: PROCEDURE: Coronary Angiography and Multimodal Coronary Physiology Study (FFR, CFR, HMR)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Quantitative Assessment of Painful Diabetic Peripheral Neuropathy After High Frequency Spinal Cord Stimulation
Status: COMPLETED
Conditions: Painful Diabetic Neuropathy
Interventions: DEVICE: High Frequency Spinal Cord Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation of a Clinical Tool to Improve Waitlist Mortality in Patients With Cystic Fibrosis
Status: RECRUITING
Conditions: Cystic Fibrosis|Lung Transplant; Complications
Interventions: OTHER: Clinical Tool (Mobile Spirometry and Survey)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Anakinra in Hidradenitis Suppurativa
Status: COMPLETED
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: Water for injection|DRUG: Anakinra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Follow-up of Patients Treated With Miltenyi Cell and Gene Therapies
Status: RECRUITING
Conditions: Melanoma Stage III|B-cell Non Hodgkin Lymphoma|Pediatric ALL|Childhood Non-Hodgkin Lymphoma|Acute Lymphatic Leukemia|Chronic Lymphatic Leukemia|Melanoma Stage IV
Interventions: BIOLOGICAL: MB-CART19.1|BIOLOGICAL: MB-CART20.1|BIOLOGICAL: MB-CART2019.1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Temozolomide With or Without Capecitabine in Treating Patients With Advanced Pancreatic Neuroendocrine Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastrinoma|Glucagonoma|Insulinoma|Islet Cell Carcinoma|Pancreatic Polypeptide Tumor|Recurrent Islet Cell Carcinoma|Somatostatinoma
Interventions: DRUG: temozolomide|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Characterize Puffing Topography With Use of JUUL Electronic Nicotine Delivery Systems (ENDS) in Adult, Closed-System ENDS Consumers
Status: COMPLETED
Conditions: Electronic Cigarette Use
Interventions: OTHER: JUUL ENDS - Virginia Tobacco 5% nicotine strength|OTHER: JUUL ENDS - Virginia Tobacco 3% nicotine strength|OTHER: JUUL ENDS - Menthol 5% nicotine strength|OTHER: JUUL ENDS - Menthol 3% nicotine strength|OTHER: JUUL ENDS - Mint 5% nicotine strength|OTHER: JUUL ENDS - Mint 3% nicotine strength|OTHER: JUUL ENDS - Mango 5% nicotine strength|OTHER: JUUL ENDS - Mango 3% nicotine strength
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Daratumumab, Pomalidomide, and Dexamethasone (DPd) in Relapsed/Refractory Light Chain Amyloidosis Patients Previously Exposed to Daratumumab
Status: RECRUITING
Conditions: Amyloid|AL Amyloidosis|Refractory AL Amyloidosis
Interventions: DRUG: Daratumumab SC|DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Biodentine, as Successful as, Mineral Trioxide Aggregate
Status: COMPLETED
Conditions: Dental Caries
Interventions: OTHER: Biodentine|OTHER: MTA pulpotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of C-MAC Videolaryngoscopy and Direct Laryngoscopy for Nasotracheal Intubation
Status: COMPLETED
Conditions: Intubation|Videolaryngoscopy|Children
Interventions: DEVICE: C-MAC videolaryngoscope|DEVICE: Direct Laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Correlation Between Corneal Topographic Patterns and Refractive Status Of The Eye in Sohag City,Egypt
Status: RECRUITING
Conditions: Eye Change
Interventions: DIAGNOSTIC_TEST: Using Oculus Pentacam® which is s a rotating Scheimpflug camera. The rotational measuring procedure generates Scheimpflug images in three dimensions.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Text 2 Connect- Texting Intervention for Mental Health Treatment Utilization
Status: COMPLETED
Conditions: Depression|Suicidal Ideation
Interventions: BEHAVIORAL: Text2Connect|BEHAVIORAL: Psychoeducational Videos (PE) Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease
Status: RECRUITING
Conditions: Interstitial Lung Disease|Common Variable Immunodeficiency
Interventions: DRUG: Abatacept|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brexpiprazole in Borderline Personality Disorder
Status: COMPLETED
Conditions: Borderline Personality Disorder
Interventions: DRUG: Rexulti|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transanal Haemorrhoidal Dearterialisation Versus Stapler Haemorrhoidopexy
Status: COMPLETED
Conditions: Haemorrhoids
Interventions: PROCEDURE: Transanal haemorrhoidal dearterialisation|PROCEDURE: Stapler haemorrhoidopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Nutritional Supplements in Treatment of Elderly Mild-to-Moderate COVID-19
Status: NOT_YET_RECRUITING
Conditions: Nutrition, Healthy
Interventions: DIETARY_SUPPLEMENT: Oral Nutritional Supplements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans
Status: NOT_YET_RECRUITING
Conditions: Traumatic Brain Injury|Mild Traumatic Brain Injury|Aging|Cognitive Decline
Interventions: BEHAVIORAL: Alpha neurofeedback training|BEHAVIORAL: Visual Attention Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Negative Emotion, Fear-Avoidance Belief and Quality of Life in Patients With Ankle Sprain
Status: UNKNOWN
Conditions: Chronic Ankle Sprain
Interventions: OTHER: Hospital Anxious and Depression(HADS)|OTHER: Fear-Avoidance Belief Questionnaire (FABQ)|OTHER: The MOS 36-Item Short From Health Survey (SF-36)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pilot Preoperative Trial of Ganetespib With Paclitaxel for Triple-Negative Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: Ganetespib|DRUG: Paclitaxel|DRUG: Doxorubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Sacral Neuromodulation for Urinary Urgency, Frequency, and Urge Incontinence
Status: TERMINATED
Conditions: Urinary Urge Incontinence
Interventions: PROCEDURE: Sacral neuromodulation device turned off
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: To Evaluate Long-Term Safety and Efficacy of Pregabalin in the Treatment of Neuropathic Pain After Spinal Cord Injury.
Status: COMPLETED
Conditions: Neuropathic Pain
Interventions: DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Breastfeeding Support on Hospitalization Due to Jaundice
Status: UNKNOWN
Conditions: Hyperbilirubinemia, Neonatal|Jaundice, Neonatal
Interventions: OTHER: Support for breastfeeding and the feeding of infants' with breast milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE