pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Biological Response to Platelet-rich Plasma and Corticosteroid Injections
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DRUG: Triamcinolone Acetonide 40 mg/ml Inj, Susp|BIOLOGICAL: Platelet-rich plasma Inj
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Palm Olein Intake on Lipid Profile and Appetite Regulation
Status: COMPLETED
Conditions: Lipidaemia
Interventions: DIETARY_SUPPLEMENT: Palm olein|DIETARY_SUPPLEMENT: Interesterified palm olein|DIETARY_SUPPLEMENT: Soybean oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long-Acting Cabotegravir Plus VRC-HIVMAB075-00-AB (VRC07-523LS) for Viral Suppression in Adults Living With HIV-1
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Oral Cabotegravir (CAB)|DRUG: Nucleoside Reverse Transcriptase Inhibitors (NRTIs)|DRUG: Long-Acting Injectable Cabotegravir (CAB LA)|BIOLOGICAL: VRC07-523LS|DRUG: Standard of Care (SOC) Oral ART
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACURATE TF™ Transfemoral Aortic Bioprosthesis for Implantation in Patients With Severe Aortic Stenosis (2011-03)
Status: COMPLETED
Conditions: Aortic Stenosis Symptomatic
Interventions: DEVICE: ACURATE TF™ Aortic Valve System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pemigatinib and Immune Checkpoint Inhibitor Treated FGFR1/2/3 Alteration Advanced Solid Tumor
Status: NOT_YET_RECRUITING
Conditions: Urothelial Carcinoma|Breast Neoplasms|Lung Cancer|Gastric Cancer|Soft Tissue Sarcoma|Other Carcinoma
Interventions: DRUG: Pemigatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy of Relapsed Refractory Neuroblastoma With Expanded NK Cells
Status: ACTIVE_NOT_RECRUITING
Conditions: Neuroblastoma
Interventions: DRUG: Dinutuximab|BIOLOGICAL: NK Cells|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Circumferential Vertebral Reconstruction of Osteoporotic Compression Fractures Using a Novel Bipedicular Peek Implant
Status: RECRUITING
Conditions: Vertebral Compression Fractures|Osteoporotic Vertebral Compression Fractures
Interventions: PROCEDURE: Vertebral Implant PEEK Procedure|DEVICE: Vertebral Implant PEEK (VIP) implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter, Uncontrolled Pilot Study Evaluating the Efficacy of Eculizumab in the Treatment of Gemcitabine-induced Thrombotic Microangiopathies
Status: NOT_YET_RECRUITING
Conditions: Thrombotic Microangiopathies
Interventions: DRUG: Eculizumab administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of RAC With Locomotion Training on Cortical Excitability and Behavior in Patients With PD
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: OTHER: Treadmill training with auditory cues|OTHER: Treadmill training without auditory cues
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inspiratory Muscle Training With Powerbreath Device in Patients With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: OTHER: Inspiratory Muscle Training with Powerbreath IMT device.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paediatric Autism Communication Therapy (PACT) in Children With Autism Spectrum Disorder
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: PACT|BEHAVIORAL: MAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quadrivalent HPV Vaccine to Prevent Anal HPV in HIV-infected Men and Women
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: Quadrivalent HPV Vaccine|BIOLOGICAL: Placebo Vaccine for Male Participants Only|BIOLOGICAL: Placebo Vaccine for Female Participants Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Changes in Measured Plasma Volume, Glycocalyx and Atrial Natriuretic Peptide During Anaesthesia
Status: COMPLETED
Conditions: Blood Pressure|Anesthesia
Interventions: DRUG: Norepinephrine|PROCEDURE: Maintained blood pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multiple Ascending Dose Study of TMP-301 in Healthy Subjects
Status: COMPLETED
Conditions: Cocaine Use Disorder|Substance Use Disorders|Healthy Volunteers
Interventions: DRUG: TMP-301|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Automatic Remifentanil Administration Guided by ANI During Propofol Anesthesia
Status: COMPLETED
Conditions: Nociceptive Pain|Surgical Procedure, Unspecified
Interventions: DEVICE: ANI-REMI-loop|DEVICE: remifentanil pK/pD target administration device|DRUG: Remifentanil|DRUG: Propofol|DEVICE: ANI monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Validation of Pupillary Response to Nociceptive Stimulation in Cardiac Surgery During Extracorporeal Circulation Period
Status: COMPLETED
Conditions: Pupil|Analgesics|Opioid Use|Dose-Response Relationship, Drug|Anesthetics, Intravenous|Surgery, Cardiac|Circulation, Extracorporeal|Electric Stimulation|Electroencephalography/Drug Effects|Monitoring, Intraoperative|Adult|Remifentanil
Interventions: DEVICE: Pupillometer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: New Perspectives in the Rehabilitation of Children With Motor Disorders : the Role of the Mirror Neuron System
Status: COMPLETED
Conditions: Hemiplegia|Cerebral Palsy
Interventions: OTHER: action observation therapy|OTHER: repetition of gestures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of PC945 on Aspergillus or Candida Lung Infections in Patients With Asthma or Chronic Respiratory Diseases
Status: TERMINATED
Conditions: Asthma|Respiratory Candidiasis|Respiratory Aspergillosis|COPD|Bronchiectasis
Interventions: DRUG: PC945|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) for Central Neuropathic Pain in Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis With Central Neuropathic Pain
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of MK0869 for the Prevention of Chemotherapy-Induced Nausea and Vomiting (0869-071)(COMPLETED)
Status: COMPLETED
Conditions: Nausea|Vomiting|Breast Neoplasms
Interventions: DRUG: MK0869, aprepitant / Duration of Treatment: 3 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Silodosin in the Treatment of Symptomatic Benign Prostatic Hyperplasia (BPH)
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: Silodosin|DRUG: Tamsulosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Canadian Study of Arterial Inflammation in Patients With Diabetes and Vascular Events: EvaluatioN of Colchicine
Status: RECRUITING
Conditions: Cardiovascular Diseases|Atherosclerosis|Inflammation|Diabetes
Interventions: DRUG: Colchicine Oral Product|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Baclofen for Rumination
Status: COMPLETED
Conditions: Rumination|Supra-gastric Belching
Interventions: DRUG: Baclofen|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Feasibility Study: Assessment of Self-Forming Magnetic Anastomosis Device and Delivery System (SFM) in Obese Patients, When Used to Create a Duodenal-Ileal Anastomosis Post SG (SNAP-PS), or Used to Create a Jejuno-Jejunal (J-J) Anastomosis
Status: RECRUITING
Conditions: Obesity, Morbid
Interventions: DEVICE: Self Forming Magnets used to Create A Compression Anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Imaging in Immune Effector Cell-Associated Neurotoxicity Syndrome
Status: COMPLETED
Conditions: Lymphoma, B-Cell|Neurotoxicity
Interventions: OTHER: Magnetic Resonance Imaging with contrast injection|OTHER: Blood withdrawal|OTHER: Neuropsychological tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetics and Pharacodynamics of GW642444 in Paedetric Subjects
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: GW642444|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Foot Exercise People With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Peripheral Neuropathy
Interventions: OTHER: Routine rehabilitation program patient education|OTHER: Routine rehabilitation program + foot exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety Study of Mepolizumab in Subjects With Severe Hypereosinophilic Syndrome (HES)
Status: COMPLETED
Conditions: Hypereosinophilic Syndrome
Interventions: DRUG: Mepolizumab 300 mg|DRUG: Placebo matching mepolizumab|DRUG: Active OCS capsules (5 mg prednisolone or prednisone)|DRUG: Placebo matching OCS capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cytochrome P450 2C19 Variant is Related to Pharmacokinetics of Glipizide Extended Release Tablet in Chinese Subjects
Status: COMPLETED
Conditions: Genotype|Pharmacokinetic
Interventions: DRUG: Glipizide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Aflibercept and FOLFOX6 Treatment for Previously Untreated Stage IV Colorectal Cancer
Status: UNKNOWN
Conditions: Mucinous Adenocarcinoma of the Colon|Mucinous Adenocarcinoma of the Rectum|Signet Ring Adenocarcinoma of the Colon|Signet Ring Adenocarcinoma of the Rectum|Stage IV Colon Cancer|Stage IV Rectal Cancer
Interventions: BIOLOGICAL: aflibercept|DRUG: oxaliplatin|DRUG: leucovorin|DRUG: fluorouracil|OTHER: Correlative Studies|PROCEDURE: DCE MRI|RADIATION: f18FDG-PET|PROCEDURE: PET (positron emission tomography)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of a Web-based Treatment Program for Depression for the Reduction of Depressive Symptoms
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Deprexis|BEHAVIORAL: Wait-list
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gut-level Antiinflammatory Activities of Green Tea in Metabolic Syndrome
Status: COMPLETED
Conditions: Dysbiosis|Endotoxemia|Metabolic Syndrome|Inflammation
Interventions: DIETARY_SUPPLEMENT: Green Tea Extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Influence of the Intestinal Microbiota on the Clinical Course of Renal Transplantation
Status: RECRUITING
Conditions: Renal Transplant
Interventions: DIETARY_SUPPLEMENT: Microbiota autotransplantation|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Retinal Fundus Flavoprotein Fluorescence in Age Related Macular Degeneration
Status: RECRUITING
Conditions: Geographic Atrophy|Age-Related Macular Degeneration
Interventions: DEVICE: OcuMet Beacon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Onvansertib + Paclitaxel In TNBC
Status: RECRUITING
Conditions: Breast Cancer|Invasive Breast Cancer|Unresectable Breast Carcinoma|Locally Advanced Breast Cancer|Metastatic Breast Cancer|Inflammatory Breast Cancer|Triple Negative Breast Cancer (TNBC)|Hormone Receptor/Growth Factor Receptor-Negative Breast Cancer|HER2-negative Breast Cancer|Hormone Receptor Negative Breast Carcinoma
Interventions: DRUG: Onvansertib|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Core Stabalization and Rebound Therapy and CP
Status: ACTIVE_NOT_RECRUITING
Conditions: Whole Body Vibration|Rebound Therapy|Balance|cp
Interventions: OTHER: core stabilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PERIOP 2 - A Safety and Effectiveness of LMWH vs Placebo Bridging Therapy for Patients on Long Term Warfarin Requiring Temporary Interruption of Warfarin.
Status: UNKNOWN
Conditions: Stroke
Interventions: DRUG: Dalteparin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Subcutaneous Treatment In Randomized Subjects To Evaluate Safety And Efficacy In Generalized Lupus Erythematosus
Status: COMPLETED
Conditions: Lupus Erythematosus, Systemic
Interventions: BIOLOGICAL: PF-04236921|BIOLOGICAL: PF-04236921|BIOLOGICAL: PF-04236921|BIOLOGICAL: PF-04236921
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Proprietary Dietary Supplement on Fecal Volatile Organic Compounds
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Placebo|DIETARY_SUPPLEMENT: Flavonoids|DIETARY_SUPPLEMENT: Flavonoids+Prebiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Extrinsic Factors on Food Allergy
Status: UNKNOWN
Conditions: Peanut Hypersensitivity
Interventions: OTHER: Food challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Phase I Study to Evaluate Safety, Tolerability in Adults With Lymphoma
Status: WITHDRAWN
Conditions: Lymphoma, B-Cell|Lymphoma, Non-Hodgkin
Interventions: DRUG: MEDI-538|DRUG: MEDI-538|DRUG: MEDI-538
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Discoloration of Carious Primary Teeth After Application of Silver Diamine Fluoride Versus Sodium Fluoride Varnish
Status: UNKNOWN
Conditions: Dental Caries in Children
Interventions: DRUG: Silver Diamine Fluoride|DRUG: Sodium Fluoride Varnish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Embodied Cognition: Exploratory Study of Automatic and Controlled Processes in Anorexia Nervosa.
Status: COMPLETED
Conditions: Anorexia Nervosa
Interventions: OTHER: TEA + Grober Test + Task 1 + Grober Test|OTHER: TEA + Grober Test + Task 2 + Grober Test|OTHER: TEA + Grober Test + Implicit Task 3 + Grober Test|OTHER: TEA + Grober Test + Explicit Task 3 + Grober Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: NP137 Clinical and Biological Activities Assessment in Patients With Advanced/Metastatic Solid Tumors Treated by Standard Anti PD-1/PD-L1 Immunotherapies
Status: RECRUITING
Conditions: Advanced Solid Tumors|Metastatic Solid Tumors
Interventions: DRUG: NP137|DRUG: anti-PD-1/PD-L1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrathin Versus Conventional Esophagogastroduodenoscopy in Unsedated Patient With or Without Local Pharyngeal Anaesthesia
Status: COMPLETED
Conditions: Dyspepsia
Interventions: PROCEDURE: Local pharyngeal anaesthesia|DEVICE: Ultrathin endoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Metabolic Syndrome and Increased Weight Using Metformin Concurrent to Androgen Deprivation Therapy and Radiotherapy for Locally Advanced Adenocarcinoma of the Prostate
Status: TERMINATED
Conditions: Prostatic Neoplasm
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Denosumab to Prevent High-Turnover Bone Loss After Bariatric Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Bariatric Surgery Candidate|Bone Loss
Interventions: DRUG: Denosumab|DRUG: Placebo|DRUG: Zoledronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ChloraPrep Versus Betadine for Elective Knee Replacement Surgery
Status: TERMINATED
Conditions: Arthroplasty, Knee Replacement|Replacement, Total Knee|Total Knee Replacement
Interventions: DRUG: Swab area with Betadine|DRUG: Swab area with ChloraPrep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase I Open-Label Study of the Effects of Tacrolimus and Cyclosporine on CP-690,555 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: CP- 690,550 and Tacrolimus|DRUG: CP- 690,550 and Cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of VSA001 Injection in Chinese Healthy Adult Volunteers
Status: NOT_YET_RECRUITING
Conditions: Healthy Adult Volunteers
Interventions: DRUG: VSA001 injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Xalacom And Combination Of Unfixed Latanoprost And Timolol In Subjects With Open-Angle Glaucoma Or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma, Open Angle|Ocular Hypertension
Interventions: DRUG: Xalacom|DRUG: unfixed Latanoprost and Timolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apnea and Insomnia Relief Study
Status: RECRUITING
Conditions: Sleep Apnea Syndromes|Insomnia Disorder|Stress Disorders, Post-Traumatic
Interventions: BEHAVIORAL: Apnea and Insomnia Relief (AIR)|BEHAVIORAL: Sleep Education (SE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Systemic Administration of Vitamin D on the Rate of Orthodontic Tooth Movement - A Randomized Control Trial
Status: COMPLETED
Conditions: Angle Class I
Interventions: DRUG: Calcitriol 0.25Mcg Cap|PROCEDURE: orthodontic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Traditional Chinese Medicine in the Supportive Management of Anaemic and Cytopenic (Leukopenia, Thrombocytopenia) Haematological Disorders
Status: COMPLETED
Conditions: Myelodysplastic Syndrome (MDS)|Aplastic Anaemia (AA)|Myelofibrosis (MF)|Thalassemia Intermedia
Interventions: DRUG: Chinese herbal concoction twice a day for 6 months
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Accuracy of the 64 Slices Computed Tomography for the Diagnosis of Left Atrial Appendage Thrombus
Status: TERMINATED
Conditions: Thrombus
Interventions: DEVICE: computed tomography|DEVICE: computed tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Post- Approval Hintermann Series H® Study 1
Status: ACTIVE_NOT_RECRUITING
Conditions: Ankle Osteoarthritis|Post-Traumatic Osteoarthritis of Ankle|Osteoarthritis of Ankle Secondary to Inflammatory Arthritis (Disorder)
Interventions: DEVICE: Hintermann Series H3 Total Ankle Replacement System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluate Safety, Tolerability, and Pharmacokinetics of Single and Repeat IV Doses
Status: COMPLETED
Conditions: Infections, Respiratory Tract
Interventions: DRUG: Part A: GSK2140944 Drug single dose of 200mg, 600mg, 1200mg, 1800 mg, and dose to be determined|DRUG: Part B: GSK2140944 Repeat Drug dose of 400mg, 750mg, 1000 mg, and dose to be determined
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: GO-203-2C + Bortezomib For Relapsed Or Refractory MM
Status: WITHDRAWN
Conditions: Multiple Myeloma|Multiple Myeloma in Relapse|Refractory Multiple Myeloma
Interventions: DRUG: GO-203-2C|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Gabapentin When Used With Naltrexone to Treat Alcohol Dependence Compared to Placebo and Naltrexone Alone
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: Naltrexone|DRUG: Naltrexone plus Gabapentin|OTHER: Inactive Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety And Efficacy Study Of Avelumab Plus Chemotherapy With Or Without Other Anti-Cancer Immunotherapy Agents In Patients With Advanced Malignancies
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer|Urothelial Cancer
Interventions: DRUG: Avelumab 800 mg in combination with pemetrexed / carboplatin|DRUG: Avelumab 800 mg in combination with gemcitabine / cisplatin.|DRUG: Avelumab 1200 mg in combination with pemetrexed/carboplatin|DRUG: Avelumab 1200 mg in combination with gemcitabine/cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Necessity of Long-term Pharmacological Treatment With Antipsychotics in Schizophrenic Patients
Status: COMPLETED
Conditions: Schizophrenia|Schizophrenia and Disorders With Psychotic Features|Schizoaffective Disorders
Interventions: DRUG: Olanzapine|DRUG: Amisulpride|DRUG: Risperidone|DRUG: Haloperidol|DRUG: Quetiapine|DRUG: Perphenazine|DRUG: Sulpiride|DRUG: bromperidol|DRUG: Zuclopenthixol|DRUG: Thioridazine|DRUG: Paliperidone|DRUG: Ziprasidone|DRUG: Benperidol|DRUG: Fluspirilene|DRUG: Pimozide|DRUG: Perazine|DRUG: Fluphenazine|DRUG: Flupentixole|DRUG: Sertindole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunosuppression Impact on the Metabolic Control of Kidney Transplant With Pre-Existing Type 2 Diabetes (DM)
Status: COMPLETED
Conditions: Kidney Transplant|Diabetes Mellitus, Type 2|Diabetic Nephropathy
Interventions: DRUG: Cyclosporin|DRUG: Tacrolimus|BEHAVIORAL: 'Diabetes Education / Management'
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Recombinant Human Acid Alpha-Glucosidase in the Treatment of Classical Infantile Pompe Disease
Status: COMPLETED
Conditions: Pompe Disease|Glycogen Storage Disease Type II|Acid Maltase Deficiency Disease|Glycogenosis 2
Interventions: DRUG: recombinant human acid alpha-glucosidase (rhGAA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of McGrath and Macintosh Laryngoscopes for Insertion of a Double Lumen Tube by Residents
Status: COMPLETED
Conditions: Thoracic Injuries
Interventions: DEVICE: macGrath|DEVICE: Macintosh's
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effects of Reducing Prolonged Sitting Bouts in Individuals at High Risk of or With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Reducing/breaking prolonged sitting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mobile-Health Delivery of Lifestyle Interventions for Women With Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Carcinoma
Interventions: BEHAVIORAL: Behavioral Intervention|OTHER: Best Practice|DEVICE: FitBit|BEHAVIORAL: Nutrition Education|OTHER: Physical Activity|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Adiposity and Iron Requirements in Pregnancy
Status: NOT_YET_RECRUITING
Conditions: Iron Deficiency Anemia of Pregnancy
Interventions: DIETARY_SUPPLEMENT: Adiposity and Iron Requirements in Pregnancy (ADIPREG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: PH94B Nasal Spray for Anxiety Induced by a Public Speaking Challenge - 2
Status: TERMINATED
Conditions: Social Anxiety Disorder
Interventions: DRUG: PH94B Nasal Spray|DRUG: Placebo Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Comparative Study on the Efficacy and Safety of Single Acupoint and Matching Acupoints
Status: UNKNOWN
Conditions: Electro-acupuncture|Chemotherapy-induced Nausea and Vomiting
Interventions: OTHER: Matching points PC6+CV12|OTHER: Single points PC6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Heart Rate Variability After Ablation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DIAGNOSTIC_TEST: Holter EKG - 1 day before ablation|PROCEDURE: Radiofrequency ablation|PROCEDURE: Pulsed field ablation|DIAGNOSTIC_TEST: Holter EKG - 1 month after ablation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clamshell Exercise in Patellofemoral Syndrome.
Status: RECRUITING
Conditions: Patellofemoral Pain Syndrome
Interventions: OTHER: Clamshell exercises|OTHER: Isometric and muscle strengthen exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Detecting Eye Diseases Via Hybrid Deep Learning Algorithms From Fundus Images
Status: COMPLETED
Conditions: Glaucoma|Age-Related Macular Degeneration|Retinal Vein Occlusion|Diabetic Retinopathy|Diabetic Macular Edema|Eye Diseases
Interventions: DRUG: Mydriatic Agent|PROCEDURE: Color Fundus Photography|DEVICE: EyeCheckup v2.0
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intra-Articular, Single-shot Injection of Hyaluronic Acid and Corticosteroids in Knee Osteoarthritis
Status: UNKNOWN
Conditions: Osteoarthritis|Pain Syndrome|Intra-articular Injection
Interventions: DRUG: hyaluronic acid|DRUG: hyaluronic acid and corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Lixisenatide Efficacy in Diabetes Mellitus Type 2 With Failure of Other GLP-1 Analog
Status: TERMINATED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: Lixisenatide|DRUG: Basal insulins
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prematurity-Related Ventilatory Control
Status: COMPLETED
Conditions: Respiratory Control in Premature Infants
Interventions: OTHER: Bedside Physiology study|OTHER: Carotid Body Function Test|OTHER: Room Air Challenge|OTHER: Hypoxia Challenge Test|OTHER: Effects of Nasal Cannula Flow|DIAGNOSTIC_TEST: Magnetic Resonance Imaging|DIAGNOSTIC_TEST: Echocardiogram|OTHER: Blood Sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Bioavailability of Teduglutide Administered Subcutaneously by Syringe Injection Versus Pen Injector in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Teduglutide|DEVICE: Syringe Injection|DEVICE: Pen injector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Rollover Protocol to Allow for Continued Access to the LSD1 Inhibitor Seclidemstat (SP-2577)
Status: ENROLLING_BY_INVITATION
Conditions: Ewing Sarcoma|Myxoid Liposarcoma|Desmoplastic Small Round Cell Tumor|Extraskeletal Myxoid Chondrosarcoma|Angiomatoid Fibrous Histiocytoma|Clear Cell Sarcoma|Myoepithelial Tumor|Low Grade Fibromyxoid Sarcoma|Sclerosing Epithelioid Fibrosarcoma
Interventions: DRUG: Seclidemstat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability & Immunogenicity of the Recombinant Plague Vaccine rF1V
Status: COMPLETED
Conditions: Pneumonic Plague|Preventive Therapy
Interventions: BIOLOGICAL: rF1V vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FAMS Mobile Health Intervention for Diabetes Self-care Support
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: REACH + FAMS|BEHAVIORAL: REACH|BEHAVIORAL: Helpline & A1c results
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Early Alzheimer's Disease
Interventions: DRUG: Semagludtide|DRUG: Placebo (semaglutide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is Routine Dissection of Central Lymph Node Necessary for Papillary Thyroid Carcinoma, T1-2 N0?
Status: UNKNOWN
Conditions: Papillary Thyroid Carcinoma
Interventions: PROCEDURE: Total thyroidectomy and central neck dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Spinal Manipulation on Sensorimotor Functions in Back Pain Patients
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: HVLA-SM|OTHER: LVVA-SM|OTHER: Sham Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Single Dose IL-6R mAb Injection in RA Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: IL-6R Monoclonal Antibody Injection 4mg/kg|BIOLOGICAL: IL-6R Monoclonal Antibody Injection 6mg/kg|BIOLOGICAL: IL-6R Monoclonal Antibody Injection 8mg/kg|BIOLOGICAL: Tocilizumab Injection 8mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Toradol (Ketorolac) in Breast Surgery to Reduce Pain & Opioid Use
Status: COMPLETED
Conditions: Breast Reduction|Breast Reconstruction
Interventions: DRUG: Ketorolac Tromethamine|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combining Curcumin With FOLFOX Chemotherapy in Patients With Inoperable Colorectal Cancer
Status: COMPLETED
Conditions: Colonic Cancer|Metastasis
Interventions: DRUG: Oral complex C3 curcumin + chemotherapy|DRUG: Chemotherapy only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Lenalidomide in Previously Untreated, Symptomatic Chronic Lymphocytic Leukemia (CLL)
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukaemia
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Opioid Consumption During TCI Guided by NOL Index or Standard Care Undergoing Intracranial Tumor Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Target Controlled Infusion|Intracranial Neoplasm|Opioid|Nociceptive Pain|Anesthesia
Interventions: DEVICE: Nociception Leve Indeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Integrated Biomarker And Imaging Study - 2
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DRUG: SB-480848|DRUG: SB-480848 matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Two-week Retreatment Interval Study for Treated Age-related Macular Degeneration Refractory to Monthly Aflibercept
Status: UNKNOWN
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: Intravitreal Aflibercept Injection 2mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Non-invasive Continuous Hemodynamic Measurement From Task Force CORE
Status: NOT_YET_RECRUITING
Conditions: Hemodynamic Measurement|Non-invasive|Cardiac Output
Interventions: DEVICE: non-invasive device (Task Force CORE(R) and Task Force CARDIO(R)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Tinostamustine, First-in-Class Alkylating HDACi Fusion Molecule, in Relapsed/Refractory Hematologic Malignancies
Status: COMPLETED
Conditions: Hematological Malignancies|Multiple Myeloma|Hodgkin's Lymphoma|Cutaneous T Cell Lymphoma
Interventions: DRUG: Tinostamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Citrulline and Arginine Supplementation on the Post-exercise Hypotension (PEH)
Status: UNKNOWN
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: L-citrulline + L-arginine|DIETARY_SUPPLEMENT: L-arginine|DIETARY_SUPPLEMENT: L-citrulline|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dentist-Patient Communication on Dental Anxiety Using the Social Media and Timing in Communication
Status: COMPLETED
Conditions: Dental Anxiety|Timing in Dentist-Patient Communication
Interventions: BEHAVIORAL: Assessment scales-the Spielberger's State-Trait Anxiety Inventory, Modified Dental Anxiety Scale and a visual analog scale.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of a Program for Routine Implementation of Symptom Distress Screening and Referral in Cancer Care
Status: RECRUITING
Conditions: Neoplasms
Interventions: OTHER: A nurse-led symptom distress screening program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Lidocaine Spray 10% Versus Oral Ibuprofen Tablets in Pain Control During Copper Intrauterine Device Insertion
Status: UNKNOWN
Conditions: Lidocaine Toxicity
Interventions: DIAGNOSTIC_TEST: The spray form may provide easy application and better patient acceptance than other forms of lidocaine administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Needle for Two-Needle Hemodialysis
Status: UNKNOWN
Conditions: End Stage Renal Disease
Interventions: PROCEDURE: Hemodialysis using the standard venous needle|PROCEDURE: Hemodialysis using a new venous needle, the "BME needle"|PROCEDURE: Hemodialysis using a new venous needle, the "BME needle"|PROCEDURE: Hemodialysis using the standard venous needle
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Point of Care Coagulation Testing in Patients Undergoing Major Surgery
Status: COMPLETED
Conditions: Blood Loss, Surgical
Interventions: DEVICE: Coagucheck XS Plus (Point of care monitor of coagulation intraoperative)|PROCEDURE: Control Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety, Tolerability, and Efficacy of IL-15 Superagonist (N-803) With and Without Combination Broadly Neutralizing Antibodies to Induce HIV-1 Control During Analytic Treatment Interruption
Status: RECRUITING
Conditions: HIV Infection
Interventions: BIOLOGICAL: N-803 (IL-15 Superagonist)|BIOLOGICAL: VRC07-523LS|BIOLOGICAL: 10-1074
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Arm Pilot Study of the Chinese Herbal Medicine Formula (SCD-2101) for the Functional Constipation in the Elderly
Status: RECRUITING
Conditions: Functional Constipation
Interventions: DRUG: SCD-2101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UZ/KU Leuven Program for Post-mortem Tissue Donation to Enhance Research
Status: RECRUITING
Conditions: Breast Cancer|Hereditary Diseases
Interventions: PROCEDURE: Blood draw|PROCEDURE: Post-mortem tissue collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pre-operative Ultrasonographic Evaluation of the Internal Jugular Vein Collapsibility Index and Inferior Vena Cava Collapsibility Index to Predict Post Spinal Hypotension in Pregnant Women Undergoing Caesarean Section
Status: UNKNOWN
Conditions: Cesarean Section
Interventions: PROCEDURE: US Internal Jugular Vein Collapsibility Index measurment|PROCEDURE: US Inferior Vena Cava Collapsibility Index measurment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Autologous TriMix-DC Therapeutic Vaccine in Combination With Ipilimumab in Patients With Previously Treated Unresectable Stage III or IV Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma Stage III|Malignant Melanoma Stage IV
Interventions: BIOLOGICAL: TriMix-DC and ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MBS314 in Participants With Relapsed/Refractory Multiple Myeloma.
Status: RECRUITING
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: DRUG: MBS314 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Clinical Trial to Evaluate the Safety, Tolerability, and Immunogenicity of SARS-CoV-2 Bivalent mRNA Vaccine (LVRNA021)
Status: ACTIVE_NOT_RECRUITING
Conditions: SARS-CoV-2
Interventions: BIOLOGICAL: SARS-CoV-2 Bivalent mRNA Vaccine|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia
Status: COMPLETED
Conditions: Presbyopia
Interventions: DRUG: PRX-100|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bimodal Analgesia as Form of Pain Control Post Long Bone Fracture
Status: WITHDRAWN
Conditions: Tibia Fracture|Femur Fracture|Humerus Fracture
Interventions: DRUG: Narcotics alone|DRUG: Narcotics and NSAIDS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotic Supplementation in Children With ADHD
Status: COMPLETED
Conditions: ADHD
Interventions: DIETARY_SUPPLEMENT: Experimental: Kefir probiotic drink (supplied by Nourish)|DIETARY_SUPPLEMENT: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sunitinib in Treating Patients With Relapsed or Refractory Diffuse or Mediastinal Large B-Cell Lymphoma
Status: COMPLETED
Conditions: Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma
Interventions: DRUG: sunitinib malate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ERAS (Early Recovery After Surgery) Protocol After Laparoscopic Total Gastrectomy and Proximal Gastrectomy
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: PROCEDURE: ERAS perioperative cares|PROCEDURE: Conventional perioperative cares
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reliability of Insulin by Jet Injection
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: jet injector|DEVICE: Conventional pen (NovoPen IV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Follow-up Study of Rotigotine Patch in Adolescent Subjects With Restless Legs Syndrome
Status: TERMINATED
Conditions: Restless Legs Syndrome
Interventions: DRUG: Rotigotine 1 mg/24 h|DRUG: Rotigotine 2 mg/24 h|DRUG: Rotigotine 3 mg/24 h
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ascending Dose Tolerability Trial and PK Assessment in Healthy Volunteers After Single & Multiple Oral Intake of DF2755A
Status: TERMINATED
Conditions: no Condition
Interventions: DRUG: DF2755A|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PD-1 Antibody Plus Bevacizumab and CAPOX as First-line Treatment for RAS-mut MSS mCRC
Status: RECRUITING
Conditions: Colorectal Cancer|RAS Mutation|Colorectal Neoplasms|Microsatellite Stable Colorectal Carcinoma
Interventions: DRUG: oxaliplatin+capecitabine+bevacizumab+PD-1 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of Recombinant Human Neuregulin-1 for Subcutaneous Administration in Patients With Chronic Systolic Heart Failure
Status: TERMINATED
Conditions: Chronic Heart Failure
Interventions: DRUG: rhNRG-1|DRUG: rhNRG-1|DRUG: rhNRG-1|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT