pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: High vs. Standard Dose Influenza Vaccine in Lung Allograft Recipients
Status: RECRUITING
Conditions: Immunization; Infection|Transplantation Infection|Influenza
Interventions: BIOLOGICAL: High Dose Quadrivalent Inactivated Influenza Vaccine|BIOLOGICAL: Standard Dose Quadrivalent Inactivated Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Breast Cancer Pre-habilitation and Prospective Surveillance to Prevent, Detect, and Optimize Physical and Function
Status: RECRUITING
Conditions: Breast Cancer
Interventions: OTHER: MOve-ABC|OTHER: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase Ib Dose-escalation Trial of Taselisib (GDC-0032) in Combination With Anti-HER2 Therapies in Participants With Advanced HER2+ Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Breast Cancer|Recurrent Breast Cancer
Interventions: DRUG: Taselisib|DRUG: Trastuzumab emtansine|DRUG: Pertuzumab|DRUG: Trastuzumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A High Protein Egg White Pudding for People With Kidney Failure (HiPE KF)
Status: NOT_YET_RECRUITING
Conditions: Kidney Failure|Frailty|Kidney Disease, Chronic
Interventions: DIETARY_SUPPLEMENT: Egg white protein pudding|DIETARY_SUPPLEMENT: : Ensure Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Splanchnic Blood Redistribution After Incretin Hormone Infusion and Obesity Surgery
Status: COMPLETED
Conditions: Type 2 Diabetes|Obesity
Interventions: PROCEDURE: Roux-en-Y|DRUG: GIP-infusion|DRUG: GLP-1|DRUG: MMS|PROCEDURE: Sleeve gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Sequential IV/PO Moxifloxacin With IV Piperacillin/Tazobactam Followed by PO Amoxicillin/Clavulanic Acid in Patients With a Complicated Skin and Skin Structure Infection
Status: COMPLETED
Conditions: Abscess|Wound Infection|Diabetic Foot|Ulcer
Interventions: DRUG: Moxifloxacin (Avelox, BAY12-8039)|DRUG: Piperacillin/Tazobactam & Amoxicillin/Clavulanic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Application of Wearable Technology to Improve the Physical Activity Level of People With Chronic Mental Illness
Status: COMPLETED
Conditions: Schizophrenia|Physical Activity|Health Knowledge, Attitudes, Practice
Interventions: DEVICE: Wearable technology|BEHAVIORAL: LINE group|BEHAVIORAL: Group activities|DEVICE: Health promotion manual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Continuous Glucose Monitoring for Glucose and Weight Management in Prediabetes and Non-severe Type 2 Diabetes: A Prospective Community-based (Workplace) Cohort Study
Status: RECRUITING
Conditions: PreDiabetes|Diabetes Mellitus, Type 2
Interventions: DEVICE: Freestyle Libre
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Catalonia Suicide Risk Code Epidemiology Study: an Epidemiological Study of Suicide Attempts in Catalonia, Spain
Status: UNKNOWN
Conditions: Suicide, Attempted|Suicide|Suicide and Self-harm
Interventions: OTHER: sociodemographic variables, somatic conditions, mental disorders, treatment and drug use
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Should the Joint Capsule of the Painful Stiff Shoulder be Ruptured During Intra-articular Hydraulic Distension?
Status: COMPLETED
Conditions: Adhesive Capsulitis
Interventions: PROCEDURE: Capsule-Preserving Intra-articular Hydraulic Distension|PROCEDURE: Capsule-Rupturing Intra-articular Hydraulic Distension
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Myelodysplastic Syndrome
Status: UNKNOWN
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: amifostine trihydrate|DRUG: cytarabine|DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Gynecologic Surgery With Robotic Assistance System Kymerax® : Pilot Study
Status: UNKNOWN
Conditions: Gynecological Surgery
Interventions: PROCEDURE: Surgical procedure with the system Kymerax|DEVICE: The system Kymerax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calaspargase Pegol-Mnkl and Cobimetinib for the Treatment of Locally Advanced or Metastatic Pancreatic Cancer
Status: RECRUITING
Conditions: Locally Advanced Pancreatic Adenocarcinoma|Metastatic Pancreatic Adenocarcinoma|Stage II Pancreatic Cancer AJCC v8|Stage IIA Pancreatic Cancer AJCC v8|Stage IIB Pancreatic Cancer AJCC v8|Stage III Pancreatic Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|DRUG: Calaspargase Pegol-mknl|DRUG: Cobimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gepant treAtments: EffectIveNess and tolERability (GAINER)
Status: RECRUITING
Conditions: Migraine|Migraine With Aura|Migraine Without Aura|Chronic Migraine
Interventions: DRUG: Rimegepant 75 MG Disintegrating Oral Tablet
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: AcoArt III / Arterio-venous Fistula in China
Status: COMPLETED
Conditions: Arteriovenous Fistula Stenosis
Interventions: DEVICE: drug-coated balloon catheter （Orchid, Acotec）|DEVICE: plain balloon catheter (Admiral, medtronic)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Clearances and Bio-compatibility of ELISIO Dialyzer
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DEVICE: ELISIO dialyzer|DEVICE: Fresenius FX100 dialyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block vs Quadratus Lumborum Block for Laparoscopic Nephrectomy
Status: RECRUITING
Conditions: Kidney Diseases|Kidney Failure
Interventions: OTHER: Postoperative analgesia management with Paracerol® and IV PCA with Talinat®|OTHER: Erector spinae plane block|OTHER: Quadratus lumborum plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Papaverine and Stereotactic Body Radiotherapy (SBRT) for Non Small Cell Lung Cancer (NSCLC) or Lung Metastases
Status: SUSPENDED
Conditions: Lung Non-Small Cell Carcinoma
Interventions: PROCEDURE: Blood Oxygen Level Dependent Imaging|DRUG: Papaverine Hydrochloride|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Significance Of Intermittently Absent End-Diastolic Flow Of The Fetal Umbilical Artery On Perinatal And Neonatal Outcomes Dr. Zeynep Kayaoğlu Yıldırım Dr. Alperen İnce Dr Gökhan Bayanmelek Dr Gökhan Bolluk
Status: COMPLETED
Conditions: Absent End-Diastolic Flow Of The Fetal Umbilical Artery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: LCZ696 (sacubitril/valsartan)|DRUG: Ramipril|DRUG: Placebo of LCZ696|DRUG: Placebo of ramipril|DRUG: Valsartan|DRUG: Placebo of valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stomach Cancer Exosome-based Detection
Status: COMPLETED
Conditions: Gastric Cancer|Gastric Adenocarcinoma|Gastric Cancer Stage|Gastric Neoplasm|Gastric Lesion|Gastric Cancer in Situ|Gastric Cancer Stage IV|Gastric Cancer Stage IIIB|Gastric Cancer Stage III|Gastric Cancer Stage IB|Gastric Cancer Stage IA|Gastric Cancer, Stage 0|Gastric Cancer Stage IIIA|Gastric Cancer Stage II|Gastric Cancer TNM Staging|Gastric Cancer Metastatic to Lung|Gastric Cancer Metastatic to Liver|Gastric Cancer Stage I|Gastric Cancer TNM Staging Primary Tumor (T) T2B
Interventions: DIAGNOSTIC_TEST: DESTINEX
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ACHIEVE2 - Safety and Preliminary Efficacy of Intravenous TCB008 in Patients With Relapse or Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)/AML
Status: NOT_YET_RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: TCB008
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Follow-Up of TX200-TR101 (STEADFAST Long Term)
Status: ENROLLING_BY_INVITATION
Conditions: Kidney Transplant Rejection|End Stage Renal Disease
Interventions: DIAGNOSTIC_TEST: Urine sample|DIAGNOSTIC_TEST: Blood sample|OTHER: Lifestyle questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Alpha Lipoic Acid Against Cardiovascular Events in Patients With Haemodialysis
Status: COMPLETED
Conditions: Hemodialysis Complication
Interventions: DIETARY_SUPPLEMENT: Alpha-Lipoic acid plus renal replacement therapy|OTHER: renal replacement therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Priming of Questionnaire Content on Grip Strength in Patients With Hand and Upper Extremity Illness
Status: COMPLETED
Conditions: Hand and Upper Extremity Illness
Interventions: OTHER: Standard PCS|OTHER: Grip Strength|OTHER: Positively Adjusted PCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on the Safety and Effectiveness of IBI318 Combined With Conventional TACE (cTACE) as a Perioperative Treatment for Potentially Resected Hepatocellular Carcinoma
Status: TERMINATED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: IBI318|PROCEDURE: cTACE|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Tranexamic Acid Versus Ecbolics in Preventing Hemorrhage During and After Cesarean Section
Status: COMPLETED
Conditions: Postpartum Hemorrhage|Blood Loss, Postoperative|Cesarean Section Complications
Interventions: DRUG: Tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Ivermectin With Favipiravir in Mild-to-moderate COVID-19 Patients
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Ivermectin Tablets|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Versus Magnesium Infusion in Reducing Agitations in Pediatric Patients Undergoing Adenotonsillectomy
Status: UNKNOWN
Conditions: Postoperative Agitations in Pediatric Patients
Interventions: DRUG: Dexmedetomidine|DRUG: Magnesium Sulphate|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Neural Mechanisms of Sevoflurane Induced Anesthesia: an EEG fMRI Study in Healthy Volunteers
Status: COMPLETED
Conditions: Anesthesia|Drug Effects
Interventions: DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Shared Health Information System for Febrile Neutropenia
Status: COMPLETED
Conditions: Febrile Neutropenia|Solid Tumor|Hematologic Neoplasms
Interventions: DEVICE: NEUTROSIS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Telephone-Based Care Management Program for Individuals With Anxiety Disorders
Status: COMPLETED
Conditions: Anxiety Disorders|Panic Disorder
Interventions: BEHAVIORAL: Telephone-based collaborative care|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Vorinostat and Tamoxifen in Newly Diagnosed Breast Cancer
Status: TERMINATED
Conditions: Stage I Breast Cancer|Stage II Breast Cancer|Stage III Breast Cancer|Invasive Breast Cancer
Interventions: DRUG: Vorinostat and Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Expert System VoiceDiab in Children With Diabetes
Status: UNKNOWN
Conditions: Type 1 Diabetes Mellitus With Hyperglycemia|Type 1 Diabetes Mellitus With Hypoglycaemia
Interventions: DEVICE: VoiceDiab expert system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Evaluation of the GLYDe Dressing for Post-surgical Incision Care
Status: COMPLETED
Conditions: Post Surgical Incisions From Abdominoplasty Procedures
Interventions: DEVICE: GLYDe Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BI 1467335 Following Multiple Dose Administration Over 28 Days
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1467335|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RCT of the 4mm vs. the 8mm Collimator for GKR of Brain Micrometastases
Status: UNKNOWN
Conditions: Brain Micrometastases
Interventions: RADIATION: GKR with a single shot of the 8 mm collimator|RADIATION: GKR with a single shot of the 4 mm collimator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Oncological Outcomes of D3 Lymph Node Dissection in Colon Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Colonic Neoplasms Malignant
Interventions: PROCEDURE: Colonic resection with D2 lymph node dissection|PROCEDURE: Colonic resection with D3 lymph node dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AGN-241751 in the Treatment of Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: AGN-241751|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Platelet-rich Plasma in Patients With Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: BIOLOGICAL: PRP injection|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamics and Pharmacokinetics of Different Glucose Bead Formulations in Obese Healthy Subjects
Status: COMPLETED
Conditions: Obese
Interventions: DRUG: Glucose 8 g coated beads (47% w/w)|DRUG: Glucose 12 g coated beads (47% w/w)|DRUG: Glucose 16 g coated beads (47% w/w)|DRUG: Glucose 12 g uncoated beads|DRUG: Glucose 12 g coated beads (60% w/w)|DRUG: Glucose 12 g coated beads (47% w/w)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glutamate for Metabolic Intervention in Coronary Surgery
Status: COMPLETED
Conditions: Coronary Artery Bypass|Myocardial Ischemia|Myocardial Infarction|Coronary Artery Disease
Interventions: DRUG: Intravenous infusion of saline|OTHER: Intravenous glutamate infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PeLear CCC: Proyecto Latino Contra Cancer Colorectal
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer|Rectal Cancer|Colon Cancer|Colon Rectal Cancer|Rectal Neoplasms|Colon Adenocarcinoma|Hereditary Nonpolyposis Colon Cancer
Interventions: OTHER: Colorectal Cancer Educational Videos in Spanish
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Stellate Ganglion Block in Herpes Zoster
Status: RECRUITING
Conditions: Pain|Neuropathic
Interventions: PROCEDURE: Stellate ganglion block|PROCEDURE: Sham Stellate ganglion block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Interpretation of Health News Items Reporting Results of Pre-clinical Studies With or Without Spin By French-speaking Population
Status: WITHDRAWN
Conditions: The Study Focus on no Specific Condition
Interventions: OTHER: New items with spin|OTHER: New items without spin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Deferasirox in Combination With Deferoxamine Followed by Deferasirox Monotherapy in Severe Cardiac Iron Overload
Status: COMPLETED
Conditions: Cardiac Iron Overload
Interventions: DRUG: Deferasirox and Deferoxamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of PR5I, a Pediatric Combination Vaccine With Enhanced Hepatitis B Component Given Concomitantly With Prevnar®
Status: COMPLETED
Conditions: Diphtheria|Pertussis|Polio|Hepatitis B|Tetanus
Interventions: BIOLOGICAL: Hybrid 5 component DTaP, Vero IPV, Hep B and PRP-OMPC|BIOLOGICAL: Hybrid 5 component DTaP, Vero IPV, Hep B and PRP-OMPC|BIOLOGICAL: Hybrid 5 component DTaP, Vero IPV, Hep B and PRP-OMPC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination of Metformin/Inulin vs Inulin on Adiponectin in Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DRUG: Metformin|DIETARY_SUPPLEMENT: Agave inulin|OTHER: Placebo of agave inulin|OTHER: Metformin placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Phacoemulsification-methods: EasyTip 2.2mm vs. Infusion Assisted EasyTip 2.2mm
Status: COMPLETED
Conditions: Cataracts
Interventions: PROCEDURE: cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Pilot Study Using Avastin and Gleevec to Treat the Progression of Intraluminal Pulmonary Vein Stenosis
Status: COMPLETED
Conditions: Pulmonary Veno Occlusive Disease
Interventions: DRUG: Bevacizumab (Avastin) and Imatinib Mesylate (Gleevec)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Pertuzumab and Trastuzumab in Patients With New Untreated Asymptomatic or Low Symptomatic Brain Metastasis in HER2 Positive Breast Cancer
Status: TERMINATED
Conditions: HER2 Positive Untreated Metastatic Breast Cancer|Asymptomatic or Low Symptomatic Brain Metastasis in Breast Cancer
Interventions: DRUG: Pertuzumab|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Vancomycin for Infection Prophylaxis in TJA
Status: NOT_YET_RECRUITING
Conditions: Infection of Total Hip Joint Prosthesis|Infection of Total Knee Joint Prosthesis
Interventions: DRUG: Vancomycin Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Human Intervention Study to Increase 25-hydroxyvitamin D Levels
Status: COMPLETED
Conditions: Vitamin D3 Deficiency
Interventions: DIETARY_SUPPLEMENT: Wheat germ oil (UV treated)|DIETARY_SUPPLEMENT: Wheat germ oil (untreated)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Drugs Talazoparib and Temozolomide in Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer|Prostate Adenocarcinoma|Prostate Neoplasm|Prostate Cancer Metastatic|Castration-resistant Prostate Cancer
Interventions: DRUG: Talazoparib|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-dose Inhaled NO Therapy for the pREvenvention of NP After Cardiac Surgery Under CPB
Status: RECRUITING
Conditions: Nosocomial Pneumonia
Interventions: DRUG: Sham treatment|DRUG: 200-ppm NO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acute Effect of Neural Mobilization in Cervical Radiculopathy: A Randomized Controlled Study
Status: COMPLETED
Conditions: Cervical Radiculopathy
Interventions: OTHER: Neural Mobilisation|OTHER: Conservative physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability of MOR106 Administered Concomitantly With Topical Corticosteroids, in Adult Participants With Moderate to Severe Atopic Dermatitis
Status: TERMINATED
Conditions: Atopic Dermatitis
Interventions: DRUG: MOR106|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Impact of a Community Health Worker Program in Neno, Malawi
Status: COMPLETED
Conditions: HIV/AIDS|Hypertension|Asthma|Diabetes|Epilepsy|Mental Health Disorder|Malnutrition|Tuberculosis|Antenatal Care|Family Planning
Interventions: BEHAVIORAL: Household model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Xenon Inhalation for Treatment of Posttraumatic Stress Disorder
Status: UNKNOWN
Conditions: Post Traumatic Stress Disorder
Interventions: COMBINATION_PRODUCT: NBTX-001 Xenon Inhaler|COMBINATION_PRODUCT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glycemic Index of Pasta From Traditional and Current Wheat Varieties
Status: UNKNOWN
Conditions: Diabetes Type 2
Interventions: OTHER: Pasta manufactured with traditional wheat varieties (Senatore Cappelli, Korasan)|OTHER: Pasta manufactured with current wheat varieties (Claudio)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Opioid Agonist and Antagonist Effects on Opioid Dependence
Status: TERMINATED
Conditions: Opioid-Related Disorders
Interventions: DRUG: Methadone|DRUG: Full opioid agonist|DRUG: Partial opioid agonist|DRUG: Opioid antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of PEG-rhG-CSF in the Prevention of Neutropenia After Chemo in Pts With Gynecological Malignancies
Status: UNKNOWN
Conditions: Gynecologic Malignant Tumor
Interventions: OTHER: Mecapegfilgrastim Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Determination and Safety Study of X4P-001 (Mavorixafor) in Participants With Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome
Status: COMPLETED
Conditions: WHIM Syndrome
Interventions: DRUG: X4P-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Equivalence of A Stable Liquid Glucagon Formulation With Freshly Reconstituted Lyophilized Glucagon
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Xeris glucagon|DRUG: Lilly glucagon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Proteins From Plant Based Diets
Status: COMPLETED
Conditions: Protein Malabsorption|Nutritional Deficiency|Nutritional Stunting
Interventions: DIETARY_SUPPLEMENT: Use of stable isotopic dilution to assess protein digestibility from Faba bean and to evaluate amino acid bioavailability
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Outcome of Patients With Primary Aldosteronism
Status: UNKNOWN
Conditions: Primary Aldosteronism|Primary Aldosteronism Due to Aldosterone Producing Adenoma|Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)|Adrenalectomy; Status|Mineralocorticoid Excess|Mineralocorticoid Antagonists [Aldosterone Antagonists] Causing Adverse Effects in Therapeutic Use|Cardiovascular Morbidity|Chronic Renal Disease|Hypokalemia
Interventions: PROCEDURE: Unilateral adrenalectomy in patients with unilateral disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Optimized Perioperative Antibiotic Prophylaxis in Radical Cystectomy
Status: COMPLETED
Conditions: Radical Cystectomy|Surgical Site Infection|Urologic Cancer|Perioperative/Postoperative Complications|Antibiotic Resistant Infection|Antibiotic Side Effect|Antibiotic-associated Diarrhea
Interventions: OTHER: Short PAP|OTHER: Extended PAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mother-Infant Intervention for Postpartum Depression and Associated Mother-Infant Relationship Dysfunction
Status: COMPLETED
Conditions: Postpartum Depression
Interventions: BEHAVIORAL: Perinatal Dyadic Psychotherapy|BEHAVIORAL: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Eight-Week Study to Evaluate the Efficacy and Safety of Saredutant in Patients With Depression
Status: COMPLETED
Conditions: Depressive Disorder
Interventions: DRUG: Saredutant succinate (SR48968C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NICU Parent Education Program
Status: COMPLETED
Conditions: Language Development|Premature Infant|Neurodevelopmental Outcomes
Interventions: OTHER: Know Your Baby Language Curriculum|OTHER: Reading Aloud Language Curriculum|OTHER: Sing A Long Language Curriculum|OTHER: Mimicking First Sounds Language Curriculum|OTHER: Language Games and Narrating Your Day Language Curriculum|OTHER: Feeding Safety|OTHER: Car Seat Safety|OTHER: Bath Safety|OTHER: Back to Sleep/SIDS prevention|OTHER: Taking a Temperature and Signs of Infection|OTHER: Infection Control Measures and Vaccine Information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Compare Conivaptan Pharmacokinetics in Subjects With Mild & Moderate Kidney Function Impairment to Subjects With Normal Kidney Function
Status: COMPLETED
Conditions: Kidney Diseases|Hyponatremia
Interventions: DRUG: conivaptan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: CT18 Infant Influenza Priming Study in Vaccine Naive Infants
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: aTIV Primer|BIOLOGICAL: QIV Primer|BIOLOGICAL: aTIV Booster|BIOLOGICAL: QIV Booster
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Intradialisis Physical Exercise in Quality of Life and Health
Status: NOT_YET_RECRUITING
Conditions: Chronic Kidney Diseases
Interventions: OTHER: cardiovascular exercise|OTHER: Muscle strength|OTHER: Mixed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Nitazoxanide in the Treatment of Clostridium Difficile-associated Disease
Status: TERMINATED
Conditions: Clostridium Infections
Interventions: DRUG: Nitazoxanide|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Minimally Invasive Surgery on Systemic Inflammatory Response in Rectal Cancer
Status: ENROLLING_BY_INVITATION
Conditions: Colorectal Cancer|Colorectal Adenocarcinoma|Rectal Cancer|Rectal Cancer Stage|Immune System Disorder
Interventions: PROCEDURE: rectal cacer surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Effects of Multiple Doses of Fidaxomicin on a Single Dose of Rosuvastatin in Healthy Male Subjects
Status: COMPLETED
Conditions: Drug-Drug Interaction (DDI)|Intestinal Absorption|Healthy Subjects|Pharmacokinetics of Rosuvastatin|Pharmacokinetics of Fidaxomicin
Interventions: DRUG: rosuvastatin|DRUG: fidaxomicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Breastfeeding and Postpartum Cardiovascular Health
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertensive Disorder of Pregnancy|Pregnancy Complications|Pre-Eclampsia|Hypertension, Pregnancy-Induced|Breastfeeding
Interventions: BEHAVIORAL: Breastfeeding self-efficacy (BSE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Peri-implantitis and Systemic Inflammation
Status: RECRUITING
Conditions: Peri-Implantitis and Systemic Inflammation
Interventions: DEVICE: Air flow device|OTHER: Hand instruments|PROCEDURE: Access flap surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of the Fluid IV Alert Monitor to Decrease the Incidence of Undetected Empty IV Bag in Dimmed Operating Rooms
Status: COMPLETED
Conditions: Anesthesia
Interventions: DEVICE: Fluid Intravenous Alert (FIVA) 'on'|DEVICE: Fluid Intravenous Alert (FIVA) 'off'
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Does Vilazodone Help With Antidepressant-associated Sexual Dysfunction?
Status: TERMINATED
Conditions: Sexual Dysfunction|Major Depressive Disorder
Interventions: DRUG: Vilazodone|DRUG: Sertraline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: STUDY OF PF-06882961 IN PARTICIPANTS WITH TYPE 2 DIABETES MELLITUS WITH VARYING DEGREES OF RENAL IMPAIRMENT AND PARTICIPANTS WITHOUT RENAL IMPAIRMENT
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Renal Impairment|Healthy
Interventions: DRUG: PF-06882961 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: HERVIN: Trastuzumab and Vinorelbine in Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: trastuzumab|DRUG: vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrated Alcohol and Sexual Assault Intervention for College Men
Status: COMPLETED
Conditions: Alcohol Drinking|Sexual Assault
Interventions: BEHAVIORAL: SAFE|BEHAVIORAL: Mindfulness-Based Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Gene and Vaccine Therapy in Treating Patients With Advanced Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Neoplasm
Interventions: BIOLOGICAL: aldesleukin|DRUG: fludarabine phosphate|DRUG: cyclophosphamide|OTHER: laboratory biomarker analysis|BIOLOGICAL: NY-ESO-1 reactive TCR retroviral vector transduced autologous PBL|BIOLOGICAL: dendritic cell vaccine therapy|RADIATION: fludeoxyglucose F 18|PROCEDURE: positron emission tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy, Safety, and Pharmacokinetics of TB006 in Participants With Acute Ischemic Stroke
Status: WITHDRAWN
Conditions: Acute Ischemic Stroke
Interventions: DRUG: TB006|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exacerbation Prevention GOLD IV COPD With Non Invasive Mechanical Ventilation
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: BiPAP Pro 2, Phillips Respironics|DEVICE: CPAP sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Co-ingesting a Low/High GI Meal With Different Fat Saturation on Postprandial Glucose, Insulin, and Triacylglycerol Responses in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: low glycemic index rice, high glycemic index rice, butter, olive oil and grapeseed oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy Assessment of Monoprost® in Comparison With Lumigan® 0.01 % and Lumigan® 0.03% Unit Dose
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Monoprost|DRUG: Lumigan 0.01%|DRUG: Lumigan 0.03% Unit Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi
Status: COMPLETED
Conditions: Preterm Birth|Periodontal Disease|Caries, Dental
Interventions: DIETARY_SUPPLEMENT: Xylitol gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Digital Ankle Brachial Index (ABI) as a Screening Tool in Detecting Peripheral Arterial Disease
Status: COMPLETED
Conditions: Peripheral Artery Disease|Amputation|Smoking|Diabetes|Hypercholesterolemia|Hypertension
Interventions: DEVICE: ABI using QuantaFlo™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Once a Day Use of Lactobacillus Casei Shirota on HIV-infected Patients Infected Patients
Status: COMPLETED
Conditions: HIV
Interventions: DIETARY_SUPPLEMENT: Fermented Milk Drink Yakult 40|DIETARY_SUPPLEMENT: Fermented Milk Drink Yakult 40
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Post Marketing Surveillance Study to Observe Safety and Effectiveness of CRYSVITA® in S. Korean Patients
Status: RECRUITING
Conditions: FGF23-related Hypophosphataemic Rickets and Osteomalacia
Interventions: DRUG: FGF23-related hypophosphataemic rickets and osteomalacia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Amphotericin B for Non-HIV Cryptococcal Meningitis Patients
Status: ENROLLING_BY_INVITATION
Conditions: Cryptococcal Meningitis|Antifungal Agents
Interventions: DRUG: Amphotericin B 0.5 mg/kg/day i.v. combined with flucytosine four times per day orally for the first 4 weeks.|DRUG: Amphotericin B 0.7 mg/kg/day i.v. combined with flucytosine four times per day orally for the first 4 weeks.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lymphatic Anomalies Registry for the Assessment of Outcome Data
Status: RECRUITING
Conditions: Lymphatic Malformation|Generalized Lymphatic Anomaly (GLA)|Central Conducting Lymphatic Anomaly|CLOVES Syndrome|Gorham-Stout Disease ("Disappearing Bone Disease")|Blue Rubber Bleb Nevus Syndrome|Kaposiform Lymphangiomatosis|Kaposiform Hemangioendothelioma/Tufted Angioma|Klippel-Trenaunay Syndrome|Lymphangiomatosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Feasibility of Home-Based Rehabilitation on Body Composition, Some Anthropometric Measures and Muscular Strength After Interruption 4-5 Years of Spinal Cord Injury: Serial Cases Study on ISIS War Survivors in Iraq
Status: COMPLETED
Conditions: Spinal Cord Injury|Rehabilitation|Exercises Program
Interventions: OTHER: Home-Based Rehabilitation rogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assess the Safety, Tolerability and Pharmacokinetics of AZD5055 Following Single and Multiple Ascending Doses in Healthy Participants
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: AZD5055|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Duloxetine for Social Anxiety Disorder: Prediction of Long Term Outcome
Status: COMPLETED
Conditions: Anxiety Disorder
Interventions: DRUG: Duloxetine|DRUG: Duloxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety of Myeloablative Conditioning, Orca-T, and Allogeneic, Donor-Derived CD19/CD22-CAR (Chimeric Antigen Receptor) T Cells in Adults With B-cell Acute Lymphoblastic Leukemia (ALL)
Status: RECRUITING
Conditions: Lymphoid Leukemia
Interventions: DRUG: Allogeneic donor-derived T-cells transduced with bivalent lentiviral vector (CD19/CD22-BBz) chimeric antigen receptor (CAR)|DRUG: Treg CD34+HSPC (Orca-T)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Ceftazidime-Avibactam Versus Standard of Care as Therapy in Febrile Neutropenic Adults With Cancer
Status: TERMINATED
Conditions: Neoplasms|Febrile Neutropenia
Interventions: DRUG: CAZ-AVI|DRUG: Vancomycin|DRUG: Linezolid|DRUG: Cefepime|DRUG: Meropenem|DRUG: Piperacillin/tazobactam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety With Vedolizumab Intravenous (IV) in Pediatric Participants With Ulcerative Colitis (UC) or Crohn's Disease (CD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Ulcerative Colitis|Crohn's Disease
Interventions: DRUG: Vedolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Remediation to Improve Mobility in Sedentary Seniors
Status: COMPLETED
Conditions: Mobility Limitation|Motor Activity|Difficulty Walking|Cognitive Ability General
Interventions: OTHER: Cognitive Remediation|OTHER: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Gilteritinib for the Treatment of ALK NSCLC
Status: RECRUITING
Conditions: Lung Non-Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Echocardiography|DRUG: Gilteritinib|PROCEDURE: Magnetic Resonance Imaging|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of LY3041658 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3041658 (SC)|DRUG: LY3041658 (IV)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Intranasal Insulin on Hepatic and Intestinal Triglyceride-rich Lipoprotein Production
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DRUG: Insulin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intravenous Immunoglobin Transfusion in Preterm Infants With Encephalopathy of Prematurity
Status: RECRUITING
Conditions: Preterm Infants
Interventions: DRUG: human gamma globulin|DRUG: non-human gamma globulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemotherapy and Low-dose Radiotherapy Sequential Concurrent Chemoradiotherapy for Locally Advanced Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: RADIATION: low-dose radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Digital Gaming for Persons With Traumatic Brain Injury
Status: COMPLETED
Conditions: Brain Injuries|Traumatic Brain Injury|TBI (Traumatic Brain Injury)|Injury, Brain, Traumatic|Brain Injuries, Traumatic
Interventions: BEHAVIORAL: The rehabilitation gaming|BEHAVIORAL: The entertaining gaming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I Clinical Study of a GamLPV, a Live Intranasal Bordetella Pertussis Vaccine
Status: COMPLETED
Conditions: Whooping Cough
Interventions: BIOLOGICAL: Vaccine GamLPV|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Neuroimaging Ancillary Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Iron Deficiency Anemia|Iron Deficiency Anemia of Pregnancy|Neurodevelopmental Disorder of Foetus|Iron Deficiency Anemia Treatment|Fetal Neurodevelopmental Disorder|Child Development
Interventions: DRUG: Ferric carboxymaltose|DRUG: Iron isomaltoside|DRUG: Ferric Sulfate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 6-0 Fast Absorbing Gut Versus 5-0 Fast Absorbing Gut for Linear Wound Closure
Status: COMPLETED
Conditions: Surgical Wound Cosmesis
Interventions: DEVICE: 6-0 fast absorbing gut suture|DEVICE: 5-0 fast absorbing gut suture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Role of Ultrasound Guide Greater Occipital Nerve Block at Second Cervical Vertebra in Migraine Headache Prophylaxis
Status: NOT_YET_RECRUITING
Conditions: Migraine Disorders
Interventions: DRUG: Placebo|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: RCT for Pregabalin in Restless Legs Syndrome in South Korea
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DRUG: Pregabalin 75mg|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effects of Intrathecal Morphine and Bilateral Erector Spina Plane Block in Elective Cesarean Section
Status: COMPLETED
Conditions: Opioid Use|Postoperative Pain
Interventions: PROCEDURE: Erector Spinae Plane Block (bilaterally, via 20ml % 0.5 bupivacain) and Intrathecal Morphine (100 mcg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING