pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Oxidative Stress and Inflammation Caused by Intravenous Iron in Crohn's Disease Patients With Iron Deficiency Anemia
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: erythropoietin|DRUG: enteral nutrition.|DRUG: injection of iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Interceptive Strategies on the Clinical Outcome of Impacted Maxillary Permanent Canines
Status: NOT_YET_RECRUITING
Conditions: Tooth Impaction|Canine Teeth
Interventions: OTHER: Interceptive Slow Maxillary Expansion with removable plates
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Functional Bread Dadih on Microbiota Profile of Weight Increase Pregnant Women and Infant Birth Weight
Status: COMPLETED
Conditions: Birth Weight|Pregnancy Weight Gain
Interventions: OTHER: Bread and vla dadiah|OTHER: Bread and vla without dadiah
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Connectomic Deep Brain Stimulation for Obsessive Compulsive Disorder
Status: SUSPENDED
Conditions: Obsessive Compulsive Disorder (OCD)
Interventions: DEVICE: Selective focal stimulation of ALIC-pathways
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trans-spinal Magnetic Stimulation (TsMS) in Parkinson's Disease- Related Musculoskeletal Pain
Status: COMPLETED
Conditions: Musculoskeletal Pain|Parkinson Disease
Interventions: DEVICE: Trans-spinal Magnetic Stimulation (TsMS)|DEVICE: Sham Trans-spinal Magnetic Stimulation (TsMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperatively Treated Patients With Lower Limb Fracture With or Without an Anti-gravity Treadmill
Status: COMPLETED
Conditions: Muscle Degeneration
Interventions: OTHER: anti-gravity treadmill (alter G®)|OTHER: standardized physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-Dose Radiation Therapy Plus Chemotherapy in Treating Patients With Advanced Nose or Throat Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: cisplatin|DRUG: fluorouracil|PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Effect of Smoking Cessation in COPD Patients After Shared Decision Making Intervention
Status: COMPLETED
Conditions: Copd|Smoking Cessation|Psychological Dependence
Interventions: BEHAVIORAL: Use different methods of teaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Oral Mucositis and Quality of Life With a Mucosa Topical Composition in Head & Neck Cancer Patients.
Status: COMPLETED
Conditions: Oral Mucositis|Quality of Life|Mucositis|Pain|Speech|Saliva|Radiation Toxicity|Chemotherapeutic Toxicity
Interventions: COMBINATION_PRODUCT: Composition comprising olive oil, xylitol and betaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SAVES-IBD: Safety & Efficacy of Aspirin vs. Standard of Care for VTE Prophylaxis After IBD Surgery
Status: WITHDRAWN
Conditions: Crohn Disease|Ulcerative Colitis|Venous Thromboembolism
Interventions: DRUG: Aspirin 81Mg Ec Tab|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Test Whether Different Doses of BI 456906 Are Effective in Treating Adults With Type 2 Diabetes.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: BI 456906|DRUG: Placebo|DRUG: Semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Drug Monitoring in Child and Adolescent Psychiatry
Status: COMPLETED
Conditions: Depression|Anorexia Nervosa|ADHD
Interventions: DRUG: Atomoxetine|DRUG: Duloxetine|DRUG: Olanzapine|DRUG: Aripiprazole
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: H5-VLP + GLA-AF Vaccine Trial in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Influenza A Subtype H5N1 Infection
Interventions: BIOLOGICAL: H5-VLP + GLA-AF|BIOLOGICAL: H5-VLP alone|BIOLOGICAL: H5-VLP + Alhydrogel(R)|BIOLOGICAL: Licensed H5N1 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: N-acetylcysteine in the Treatment of PTSD and Addiction
Status: COMPLETED
Conditions: PTSD|Addiction
Interventions: DRUG: N-acetylcysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AIH for Spinal Cord Repair
Status: RECRUITING
Conditions: SCI
Interventions: BEHAVIORAL: hypoxia|BEHAVIORAL: sham hypoxia|DRUG: D-cycloserine|DRUG: sham-NMDA agonist|BEHAVIORAL: exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Community-health Worker Delivered HIV/STI Prevention Intervention for Internally Displaced Women in Leogane, Haiti
Status: COMPLETED
Conditions: Risk Reduction Behavior|Interpersonal Relations|Mental Disorders
Interventions: BEHAVIORAL: individual and group-based, community health worker delivered
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetic (PK) Analysis of Antitumor B in Patients With Oral Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Squamous Cell Carcinoma of the Oral Cavity
Interventions: DRUG: Antitumor B
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Perioperative Intervention to Reduce Metastatic Processes in Pancreatic Cancer Patients Undergoing Curative Surgery
Status: RECRUITING
Conditions: Pancreatic Neoplasms
Interventions: DRUG: Propranolol and etodolac|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety of Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Armodafinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Checklists and Upright Positioning in Endotracheal Intubation of Critically Ill Patients (Check-UP) Trial
Status: COMPLETED
Conditions: Respiratory Failure
Interventions: PROCEDURE: Written Checklist|PROCEDURE: Head of Bed Up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Open Label Trial of Rapastinel (Formerly GLYX-13) in Individuals With Obsessive-Compulsive Disorder
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder (OCD)
Interventions: DRUG: Rapastinel (formerly GLYX-13)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Curcumin to Treat Unfavorable Bleeding Patterns in Contraceptive Implant Users
Status: COMPLETED
Conditions: Bleeding|Implants|Breakthrough Bleeding
Interventions: DRUG: Placebo|DRUG: Curcumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protocolized Diuretic Strategy in Cardiorenal Failure
Status: TERMINATED
Conditions: Cardiac Failure|Renal Failure|Kidney Failure
Interventions: DRUG: Protocolized Diuretic Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Surgery of Melanoma Metastases After Systemic Therapy
Status: WITHDRAWN
Conditions: Melanoma|Melanoma Stage IV|Metastatic Melanoma|Surgery
Interventions: PROCEDURE: Surgical metastasectomy|DRUG: Immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post Caesarean-Section Pain Control Regimens: Oral Regimen With and Without Transversus Abdominis Plane Block
Status: COMPLETED
Conditions: Reduction in Post Ceasarean-section Related Pain in Study Group (TAP Block)
Interventions: PROCEDURE: TAP block (Bupivacaine 0.25% with epinephrine)|PROCEDURE: Sham block control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Music Listening in Odontostomatological Surgery (PMLOS)
Status: COMPLETED
Conditions: Stage I or II Micro-invasive Oral Cancer
Interventions: OTHER: music therapy intervention|DRUG: Standard Preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Improving Neurologic Outcomes in People With Diabetes Who Are Undergoing Heart Surgery
Status: COMPLETED
Conditions: Diabetes Mellitus|Cardiovascular Diseases
Interventions: BEHAVIORAL: Intensive Glucose Management|BEHAVIORAL: Traditional Glucose Management:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of a Distal Targeting System for Cephalomedullary Nails as Part of Surgical Repair of Hip and Femoral Shaft Fractures
Status: COMPLETED
Conditions: Hip Fractures|Femoral Shaft Fractures
Interventions: PROCEDURE: Standard of Care|PROCEDURE: Distal targeting device technique of distal screw placement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Stockholm CREAtinine Measurements Project
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Acute Kidney Injury|Diabetes Mellitus|Cardiovascular Diseases|Hypertension
Interventions: DRUG: Initiation of specific medications|PROCEDURE: Undertaking of specific procedures|DIAGNOSTIC_TEST: Abnormalities in specific laboratory tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Buccal Infiltration During Vital Pulpotomy After Administering Two Analgesic Premedications
Status: COMPLETED
Conditions: Anesthesia, Local
Interventions: DRUG: Brufen|DRUG: Cital|DRUG: Placebo for Brufen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Mitochondrial Disease
Interventions: DRUG: KL1333|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Controlled Nitric Oxide Releasing Patch Versus Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis
Status: TERMINATED
Conditions: Cutaneous Leishmaniasis
Interventions: DRUG: controlled nitric oxide releasing patch|DRUG: meglumine antimoniate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)
Status: RECRUITING
Conditions: Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
Interventions: BIOLOGICAL: NTLA-2001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Intrathecal Administration of Onasemnogene Abeparvovec-xioi for Spinal Muscular Atrophy
Status: TERMINATED
Conditions: Spinal Muscular Atrophy
Interventions: BIOLOGICAL: Onasemnogene Abeparvovec-xioi
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Medical Evaluation of the T50 Test
Status: COMPLETED
Conditions: Renal Failure|Cardiovascular Diseases|Vascular Calcification
Interventions: DIAGNOSTIC_TEST: T50 Calcification Inhibition Test (CIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Applicability of the Acai Fruit (Euterpe Oleracea) Dye for Chromovitrectomy in Humans
Status: COMPLETED
Conditions: Epiretinal Membrane|Macular Hole|Diabetic Retinopathy
Interventions: OTHER: Acai dye 10%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: An Investigational Drug Study With Suberoylanilide Hydroxamic Acid in Relapsed Diffuse Large B-cell Lymphoma (0683-013)
Status: COMPLETED
Conditions: B-cell Lymphoma
Interventions: DRUG: MK0683, vorinostat, Suberoylanilide Hydroxamic Acid (SAHA) / Duration of Treatment 6 Months
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crossover Study to Evaluate the Relative Bioavailability and Palatability of a Lenvatinib Suspension Compared to the Capsule Formulation in Adult Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Stress Management in Outpatient Surgery With L-tyrosine Supplementation (SPOT)
Status: NOT_YET_RECRUITING
Conditions: Stress
Interventions: DIETARY_SUPPLEMENT: L-tyrosine supplementation|DIETARY_SUPPLEMENT: Placebo supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Vitamin D Supplementation and Sunlight Exposure in Brazilian Women Living in Opposite Latitudes (The D-SOL Study)
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D supplementation|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: G1T38, a CDK 4/6 Inhibitor, in Combination With Osimertinib in EGFR-Mutant Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung|Lung Cancer|Non-small Cell Lung Cancer
Interventions: DRUG: G1T38|DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Metastatic Cancer That Overexpresses P53 Using Lymphodepleting Conditioning Followed by Infusion of Anti-P53 TCR-Gene Engineered Lymphocytes
Status: COMPLETED
Conditions: Anti-p53 TCR-Gene
Interventions: BIOLOGICAL: anti-protein 53 or tumor protein 53 (p53) T-cell receptor transduced peripheral blood lymphocytes|BIOLOGICAL: aldesleukin|BIOLOGICAL: filgrastim|DRUG: cyclophosphamide|DRUG: fludarabine phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Laser Combined With Pulp-capping Agents on Direct Pulp Capping
Status: COMPLETED
Conditions: Dental Pulp Exposure
Interventions: OTHER: Calcium Hydroxide|OTHER: Er,Cr:YSGG laser + calcium hydroxide|OTHER: TheraCal LC|OTHER: Er,Cr:YSGG laser + TheraCal LC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Dystussia in Traumatic Brain Injury
Status: COMPLETED
Conditions: TBI|Brain Injury
Interventions: BEHAVIORAL: Neuropsychological Testing and Measures of TBI severity|BEHAVIORAL: Respiratory measures|DRUG: Capsaicin cough sensitivity testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Evaluation of Central Sensitization, Fear-Avoidance, and Pain-Pressure Threshold With Chronic Pain After Hysterectomy
Status: UNKNOWN
Conditions: Hysterectomy|Chronic Pain|Central Sensitisation|Anxiety Depression
Interventions: DIAGNOSTIC_TEST: Pain-Pressure Threshold|DIAGNOSTIC_TEST: Mechanical Temporal Summation|DIAGNOSTIC_TEST: Hospital Anxiety and Depression Scale|DIAGNOSTIC_TEST: Pain Catastrophizing Scale|DIAGNOSTIC_TEST: Central Sensitization Inventory|DIAGNOSTIC_TEST: Fear-Avoidance Component Score|DIAGNOSTIC_TEST: EQ-5D|DIAGNOSTIC_TEST: heart rate variability|DIAGNOSTIC_TEST: Anxiety, anticipated pain, anticipated analgesia|DIAGNOSTIC_TEST: State-trait anxiety inventory|DIAGNOSTIC_TEST: Beck's Depression Inventory
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Roflumilast in Non-CF Bronchiectasis Study (2019)
Status: RECRUITING
Conditions: Non-cystic Fibrosis Bronchiectasis
Interventions: DRUG: Roflumilast Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Whitening Efficacy of Dentifrice Containing 10% High Cleaning Silica, 0.5% Sodium Phytate and 0.5% Sodium Pyrophosphate
Status: COMPLETED
Conditions: Tooth Bleaching
Interventions: DRUG: Toothpaste containing 10% high cleaning silica base, 0.5% sodium phytate and 0.5% sodium pyrophosphate|DRUG: Control toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison Of Valdecoxib 20 Mg Twice Daily and 40 Mg Daily and Placebo In The Treatment Of Sore Throat
Status: COMPLETED
Conditions: Pharyngitis
Interventions: DRUG: valdecoxib|DRUG: valdecoxib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Rapeseed and Sunflower Oils on Proteomic Biomarkers of Diseases.
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DIETARY_SUPPLEMENT: Rapeseed oil|DIETARY_SUPPLEMENT: Sunflower oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Joint Real-World Study of Digital Smoking Cessation Interventions
Status: NOT_YET_RECRUITING
Conditions: Tobacco Smoke Pollution|Passive Smoking|Secondhand Smoking
Interventions: COMBINATION_PRODUCT: Digital Smoking Cessation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects Who Are Intolerant to Statins
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DRUG: Bococizumab (PF-04950615;RN316)|DRUG: Atorvastatin|OTHER: Placebo for Bococizumab (PF-04950615;RN316)|OTHER: Placebo for atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Once Daily Dosing Compared to Twice Daily Dosing of Nitisinone in HT-1
Status: COMPLETED
Conditions: Hereditary Tyrosinemia, Type I
Interventions: DRUG: Nitisinone
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Use of Oxytocin and Misoprostol in the Prevention of Post Partum Haemorrhage
Status: TERMINATED
Conditions: Hemorrhage; Complicating Delivery
Interventions: DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Prognostic Value of the Marker P63 in Adenocarcinoma of Lung, Breast, and Pancreas
Status: UNKNOWN
Conditions: Lung Adenocarcinoma|Breast Adenocarcinoma|Pancreatic Ductal Adenocarcinoma
Interventions: OTHER: their will be no intervention in any of the groups, the study is retrospective
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Simultaneous Endotracheal Tube Insertion With GlideScope Use
Status: COMPLETED
Conditions: Intubation|Videolaryngoscopy
Interventions: PROCEDURE: Simultaneous Intubation|PROCEDURE: Standard Intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Gemcitabine-erlotinib Versus Gemcitabine-erlotinib-capecitabine in Patients With Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: Gemcitabine+erlotinib|DRUG: Gemcitabine+erlotinib+capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inspiratory Muscle Training in ME/CFS and COVID-19 Survivors
Status: COMPLETED
Conditions: Myalgic Encephalomyelitis|Post-acute COVID-19 Syndrome
Interventions: OTHER: Inspiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Restoration vs. Compensation in Neurovisual Rehabilitation of Visual Field Defects
Status: COMPLETED
Conditions: Hemianopia|Brain Injuries, Traumatic
Interventions: BEHAVIORAL: Vision Restoration Training (VRT)|BEHAVIORAL: Vision Exploration Training (VET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tiotropium In Early Chronic Obstructive Pulmonary Disease Patients in China
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Tiotropium|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Repetitive Electric Sensory Stimulation (RSS) as Intervention in Complex-regional-pain-syndrome Type I (CRPS)
Status: UNKNOWN
Conditions: Complex Regional Pain Syndrome Type I of the Upper Limb
Interventions: DEVICE: RSS (repetitive sensory stimulation)|DEVICE: SHAM-RSS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Crossover Study to Assess the Effect of Intravenous Infusion of Piperacillin/Tazobactam on the Pharmacokinetics of Orally Administered Lumicitabine (JNJ-64041575) in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lumicitabine|DRUG: Piperacillin/Tazobactam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Using Musical and Lighted Baby Crib Mobile on Newborns' Pain and Stress During Blood Draw
Status: COMPLETED
Conditions: Pain
Interventions: OTHER: The musical and lighted baby crib mobile:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)
Status: NOT_YET_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Cemiplimab|DRUG: Platinum-based chemotherapy|DRUG: REGN7075
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: African Glaucoma Laser Trial
Status: WITHDRAWN
Conditions: Open-angle Glaucoma
Interventions: PROCEDURE: Selective laser trabeculoplasty (SLT)|DRUG: Latanoprost ophthalmic solution|DRUG: Timolol ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prazosin vs. Paroxetine in Combat Stress Symptoms in OIF/OEF Returnees
Status: COMPLETED
Conditions: Sleep Disorders|Stress Disorders, Post-Traumatic
Interventions: DRUG: Paroxetine|DRUG: Prazosin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Static vs. Articulating Antibiotic Spacer for Periprosthetic Joint Infection in Total Knee Arthroplasty
Status: TERMINATED
Conditions: Prosthetic Joint Infection of the Knee
Interventions: DEVICE: Static Antibiotic Spacer Surgical Implant|DEVICE: Articulating Antibiotic Spacer Surgical Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Infiltration With Levobupivacaine During Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Laparoscopic Cholecystectomy|Postoperative Pain|Local Infiltration|Levobupivacaine
Interventions: DRUG: Preincisional infiltration with levobupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy of Seattle-PAP for the Respiratory Support of Premature Infants
Status: UNKNOWN
Conditions: Premature Birth
Interventions: DEVICE: Seattle-PAP|DEVICE: Conventional bubble nasal CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-Inflammatory Pulmonal Therapy of CF-Patients With Amitriptyline and Placebo
Status: COMPLETED
Conditions: Cystic Fibrosis|Infection|Pseudomonas Aeruginosa
Interventions: DRUG: amitriptyline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Zoledronic Acid in the Prevention of Cancer Therapy-induced Bone Loss
Status: TERMINATED
Conditions: Primary Hormone Receptor Negative Breast Cancer in Premenopausal Women
Interventions: DRUG: Zoledronic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of 1,25-dihydroxyvitamin D3, Treatment on Insulin Secretion and Muscle Strength in Pre-diabetic Persons
Status: TERMINATED
Conditions: Pre-Diabetic
Interventions: DRUG: Calcitriol capsules|DRUG: Oral Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Akt Inhibitor MK2206 in Treating Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Status: COMPLETED
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: Akt Inhibitor MK2206|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interactions of Hepatitis C Viral (HCV) Dynamics and Immune Activation in HIV Coinfected Patients During HCV Treatment
Status: COMPLETED
Conditions: Human Immunodeficiency Virus|Chronic Hepatitis C
Interventions: DRUG: pegylated interferon-alpha (Pegasys)|DRUG: ribavirin (COPEGUS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ezetimibe Versus Nutraceuticals in Statin-intolerant Patients
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: Ezetimibe|DRUG: Nutraceuticals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Perspective Study: Clinical Evaluation of the Persona MC® With Preservation or Sacrifice of the PCL
Status: COMPLETED
Conditions: Prosthesis Survival
Interventions: PROCEDURE: Total knee arthroplasty|DEVICE: Persona Medial Congruent Knee Prosthesis implantation with Posterior Cruciate Ligament retaining|DEVICE: Persona Medial Congruent Knee Prosthesis implantation with Posterior Cruciate Ligament sacrifice
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Angelica Gigas N. Extract on Improvement of Hyperglycemia
Status: COMPLETED
Conditions: Hyperglycemia
Interventions: DIETARY_SUPPLEMENT: Angelica gigas N. extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Learn How Elinzanetant Moves Into, Through, and Out of the Body, How Safe it is, and How it Affects the Body in Participants With Kidneys That do Not Work as Well as They Should Compared to Participants Whose Kidneys Work Normally
Status: COMPLETED
Conditions: Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men
Interventions: DRUG: Elinzanetant (BAY3427080)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Dendritic Cell Vaccination in Mesothelioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Pleural Mesothelioma
Interventions: BIOLOGICAL: dendritic cell vaccination plus chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of the 5-Step Method in the U.S.
Status: NOT_YET_RECRUITING
Conditions: Family Members|Relatives|Substance-Related Disorders|Alcohol-Related Disorders|Coping Skills|Stress, Psychological|Stress Physiology
Interventions: BEHAVIORAL: 5-Step Method Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Hematopoietic Stem Cell Transplantation in Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: PROCEDURE: Autologous hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Baduanjin Exercise for Patients With GOLD 2-3 Stable COPD on Pulmonary Rehabilitation
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: Baduanjin exercise|DEVICE: Instrument rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study With Heptral in Subjects With Liver Disease Due to Alcohol Consumption
Status: COMPLETED
Conditions: Intrahepatic Cholestasis Associated With Alcoholic Liver Disease
Interventions: DRUG: Ademetionine IV+tablet|DRUG: Ademetionine tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial
Status: COMPLETED
Conditions: Obesity|Labor Induction|Cesarean Delivery
Interventions: DRUG: Vaginal Misoprostol|DEVICE: Foley Balloon + Vaginal Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using a Video Otoscope in Pediatric Ear Examination: A Prospective Randomized Controlled Study:
Status: COMPLETED
Conditions: Parental Satisfaction of Using Video Otoscopy in Pediatric Emergency Room
Interventions: DEVICE: DE500 Digital Video Otoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Falls Prevention for Visually Impaired Older People
Status: UNKNOWN
Conditions: Accidental Fall|Visual Impairment|Fall
Interventions: OTHER: 5 day falls prevention training|OTHER: Home exercise programme|OTHER: Environmental Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Alpha-lipoic Acid in Diabetic Nephropathy
Status: RECRUITING
Conditions: Type 1 Diabetes
Interventions: DRUG: Thioctic Acid 333 MG Oral Capsule|DRUG: Captopril 25Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Liraglutide 3.0mg in Patients With Poor Weight-loss and a Suboptimal Glucagon-like Peptide-1 Response
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Liraglutide Pen Injector [Saxenda]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of OR3O™ Dual Mobility System vs. Conventional Single Bearing Design Total Hip System
Status: TERMINATED
Conditions: Degenerative Hip Joint Disease|Rheumatoid Arthritis (RA)|Femoral Neck Fractures|Avascular Necrosis of Femoral Head|Osteoarthritis (OA)|Hip Dislocation|Hip Fractures
Interventions: DEVICE: OR3O™ - Dual Mobility System|DEVICE: Conventional
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycemic Index of Traditional Egg Pasta
Status: COMPLETED
Conditions: Glycemic Response|Insulinemic Response|Healthy Subjects
Interventions: OTHER: glucose solution|OTHER: Traditional egg pasta|OTHER: Pasta with eight egg whites/kg flour|OTHER: Pasta with four eggs/kg flour|OTHER: Hyperproteic pasta (with added gluten and albumin)|OTHER: Pasta with only four egg whites/kg flour
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Clinical Trial to Test a Study Drug in Volunteers Who Develop Asthma Following Exercise
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Placebo|DRUG: GSK2190915
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of AZD1775 in Combination With Paclitaxel, in Advanced Gastric Adenocarcinoma Patients Harboring TP53 Mutation as a Second-line Chemotherapy
Status: COMPLETED
Conditions: Advanced Gastric Adenocarcinoma
Interventions: DRUG: AZD1775|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Prospective Double-Blind Placebo-Controlled Randomized Clinical Trial of Losartan to Treat Grade II & III Hamstring Strains
Status: TERMINATED
Conditions: Hamstring Injury
Interventions: DRUG: Losartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics, Bioavailability, Food Effect, Drug-Drug Interaction Study of APX001 Administered Orally
Status: COMPLETED
Conditions: Fungal Infection
Interventions: DRUG: APX001 single IV dose|DRUG: APX001 single oral dose 1|DRUG: APX001 single oral dose 2|DRUG: APX001 single oral dose 3|DRUG: APX001 single oral dose fasted|DRUG: APX001 single oral dose fed|DRUG: APX001 multiple oral doses 1|DRUG: APX001 multiple oral doses 2|DRUG: APX001 multiple oral doses 3|DRUG: Cytochrome P450 substrates|DRUG: Matching placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of NOX66 in Combination With Palliative Radiotherapy in Patients With Late-Stage Prostate Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: NOX66|RADIATION: Irradiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Whole Lung IMRT in Children and Adults With Synovial Sarcoma and Lung Metastases
Status: COMPLETED
Conditions: Synovial Sarcoma|Single or Multiple Lung Metastases
Interventions: RADIATION: Whole Lung IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet Count, Platelet, Mean Platelet Volume and Platelet Distribution Width in COVID-19
Status: COMPLETED
Conditions: Covid-19|Mean Platelet Volume|Platelet Destruction
Interventions: DIAGNOSTIC_TEST: Platelet count, platelet, mean platelet volume and platelet distribution Width in COVID-19
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Aleglitazar in Type 2 Diabetes Patients With Moderate Renal Impairment
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: aleglitazar|DRUG: pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mobile Smoking Cessation Intervention in Enhancing Cancer Outreach in Low-Income Adult Smokers
Status: COMPLETED
Conditions: Cigarette Smoker|Current Every Day Smoker
Interventions: OTHER: Laboratory Biomarker Analysis|BEHAVIORAL: Smoking Cessation Intervention|BEHAVIORAL: Telephone-Based Intervention|OTHER: Tobacco Cessation Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of a Physical Activity Program on Bone Mineral Density in Children and Adolescents With Chronic Inflammatory Bowel Disease
Status: RECRUITING
Conditions: Crohn's Enteritis|Crohn Disease|Ulcerative Colitis|Chronic; Colitis (Noninfective)
Interventions: OTHER: Usual care|OTHER: adapted physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Adebrelimab Combined With Albumin Paclitaxel and Nedaplatin as Neoadjuvant Therapy for Locally Advanced Resectable ESCC
Status: NOT_YET_RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Adebrelimab|DRUG: albumin paclitaxel|DRUG: Nedaplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closed-Loop Glucagon Pump for Treatment of Post-Bariatric Hypoglycemia
Status: COMPLETED
Conditions: Post-bariatric Hypoglycemia
Interventions: DRUG: glucagon|DEVICE: Closed loop glucagon pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nitroglycerin Versus Labetalol in Acute Severe Pre-eclampsia
Status: COMPLETED
Conditions: Severe Pre-eclampsia
Interventions: DRUG: Labetalol and Glyceril trinitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Standard Craniectomy Against Laparotomy for the Treatment of Traumatic Rise in Intracranial Pressure and the Effect on Long-term Outcome
Status: RECRUITING
Conditions: Traumatic Brain Injuries
Interventions: PROCEDURE: Decompressive Laparotomy|PROCEDURE: Decompressive Craniectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Controlled Trial of Probiotic and Peanut Oral Immunotherapy (PPOIT) in Inducing Tolerance in Hong Kong Children With Peanut Allergy Compared With Oral Immunotherapy (OIT) Alone and With Placebo
Status: ACTIVE_NOT_RECRUITING
Conditions: Peanut Allergy|Food Allergy in Children
Interventions: COMBINATION_PRODUCT: PEANUT OIT: Peanut Flour (50% peanut protein) that is prepared under food manufacturing regulations|COMBINATION_PRODUCT: PEANUT OIT: Peanut Flour (50% peanut protein) that is prepared under food manufacturing regulations|COMBINATION_PRODUCT: PEANUT PLACEBO: Peanut Placebo is maltodextrin powder with food colouring and peanut essence that has similar appearance, taste and smell to the active product.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Pharmacokinetics (PK) and Safety of Tavapadon in Participants With Mild and Moderate Hepatic Impairment Compared to Participants With Normal Hepatic Function
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: Tavapadon
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Health Effects of Low Temperature Exposure
Status: NOT_YET_RECRUITING
Conditions: Cardiovascular System|Respiratory System|Cognitive Function
Interventions: OTHER: Low temperature (16#) group|OTHER: Moderate temperature (22#) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Safety and Effectiveness of Transcatheter Aortic Valve Raplacemet in Intermediate Risk Patients With Bicuspid Aortic Stenosis
Status: NOT_YET_RECRUITING
Conditions: Aortic Valve Disease
Interventions: PROCEDURE: TAVR|PROCEDURE: SAVR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A New Track Ablation Device for Liver Biopsy: A Feasibility Study
Status: UNKNOWN
Conditions: Liver Neoplasms
Interventions: DEVICE: Biopsy Track Ablator (STARmed, Goyang, Korea)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Tolerance and Acceptability of Rasagiline in the Treatment of Early-stage Parkinson's Disease
Status: TERMINATED
Conditions: Early-stage Parkinson's Disease
Interventions: DRUG: Rasagiline|DRUG: Pramipexole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Lenvatinib in Patients With Advanced HCC Who Are Refractory to Atezolizumab and Bevacizumab/ IO-based Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Pembrolizumab|DRUG: Lenvatinib Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weight Management Intervention for Obese Women and the Live Birth Outcome of in Vitro Fertilization (IVF)
Status: COMPLETED
Conditions: Infertility|Obesity
Interventions: DIETARY_SUPPLEMENT: Low calorie diet treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Performance of 18F-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) in the Diagnosis of Indeterminate Adrenal Tumors on Conventional Imaging: A French Prospective Multicentric Study
Status: COMPLETED
Conditions: Adrenal Tumors
Interventions: OTHER: FDG-PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Adding EMEND to PONV/PDNV Treatment Regimen
Status: WITHDRAWN
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: aprepitant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Pharmacokinetic Study of TRK-100STP in Japanese Patients With Renal Impairment
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: beraprost sodium(BPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Nimotuzumab in Combined With Chemoradiotherapy to Treat the Newly Diagnosed Diffuse Intrinsic Pontine Glioma in Children
Status: RECRUITING
Conditions: Diffuse Intrinsic Pontine Glioma
Interventions: DRUG: Nimotuzumab+CRT(concurrent IMRT and TMZ)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxidative Stress and Cardiovascular Morbidity in Sleep Apnea-Hypopnea Syndrome (SAHS)
Status: COMPLETED
Conditions: Sleep Apnea|Cardiovascular Diseases
Interventions: DEVICE: nasal CPAP|DEVICE: Sham CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE