pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pregnancy Outcomes With a GnRH Antagonist Protocol Versus GnRH-Agonist Protocol in ICSI Cycles
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: oocyte retrieval and ICSI procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety, Efficacy, Pharmacokinetics, and Immunogenicity of Test Pertuzumab (ZRC-3277, Cadila Healthcare Ltd.,)
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: BIOLOGICAL: Pertuzumab (ZRC-3277)|BIOLOGICAL: Pertuzumab (Perjeta®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modelling the Interaction Between Rationally-designed Synthetic Model Viral Protein Immunogens
Status: UNKNOWN
Conditions: HIV-1-infection
Interventions: BIOLOGICAL: ConM SOSIP|BIOLOGICAL: EDC ConM SOSIP|BIOLOGICAL: ConS UFO|BIOLOGICAL: EDC ConS UFO|BIOLOGICAL: Mosaic SOSIPs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: F-18 FDOPA PET/CT Versus I-123 MIBG Scintigraphy With SPECT/CT for the Diagnosis of Pheochromocytoma and Paraganglioma
Status: TERMINATED
Conditions: Pheochromocytoma|Paraganglioma
Interventions: DIAGNOSTIC_TEST: F-18 FDOPA PET/CT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Sargramostim in Moderately to Severely Active Crohn's Disease
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: DRUG: Sargramostim (Leukine)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: VEGF Gene Transfer for Critical Limb Ischemia
Status: COMPLETED
Conditions: Critical Limb Ischemia|Ischemia|Leg Ulcer
Interventions: GENETIC: pVGI.1 (VEGF-2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose:
Clinical trial: External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases
Status: UNKNOWN
Conditions: Cancer
Interventions: DRUG: indinavir sulfate|DRUG: ritonavir|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Oral Immunotherapy With Baked Milk Products for Patients Allergic to Cow's Milk - A Multicenter Study
Status: COMPLETED
Conditions: Can Milk Allergic Patients Tolerate Baked Milk Products
Interventions: OTHER: Baked milk products to cow's milk allergic patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment for Patients With Non-Myeloid Malignancies Receiving Chemotherapy
Status: COMPLETED
Conditions: Cancer|Non-Myeloid Malignancies
Interventions: DRUG: rHuEPO|DRUG: Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Activated Recombinant FVII in Spinal Surgery
Status: COMPLETED
Conditions: Acquired Bleeding Disorder|Spinal Fusion
Interventions: DRUG: eptacog alfa (activated)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Mechanisms of Dapagliflozin in Promoting Kidney Function and Cardiovascular Health in Kidney Transplant Recipients
Status: RECRUITING
Conditions: Kidney Transplant; Complications|Vascular Diseases|Diabetes
Interventions: DRUG: Dapagliflozin 10mg Tab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Antipsychotic Medications in LBD Over Time
Status: RECRUITING
Conditions: Parkinson's Disease Psychosis|Dementia With Lewy Bodies
Interventions: DRUG: Pimavanserin|DRUG: Quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Bicalutamide Plus Finasteride in Men With MRI Detectable Prostate Nodules Undergoing Active Surveillance
Status: WITHDRAWN
Conditions: Detectable Prostate Nodules
Interventions: DRUG: Bicalutamide plus Finasteride- Combination therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Patient Outcome in Group Therapy for Eating Disorders
Status: UNKNOWN
Conditions: Bulimia Nervosa (BN)|Binge Eating Disorder (BED)|Eating Disorder Not Otherwise Specified (EDNOS)
Interventions: OTHER: Group psychotherapy|OTHER: Group psychotherapy with feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Contribution of Ondansetron to Preventing Post-Dural Puncture Headaches Following Spinal Anesthesia
Status: RECRUITING
Conditions: Post-Dural Puncture Headache
Interventions: DRUG: Intravenous ondansetron|DRUG: Intravenous normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Teriflunomide vs. Placebo During Gluten Challenge in Celiac Disease
Status: UNKNOWN
Conditions: Celiac Disease
Interventions: DRUG: Teriflunomide Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multimodal Approach of Electrotherapy Versus Nerve Flossing Technique in Patient With Carpal Tunnel Syndrome
Status: RECRUITING
Conditions: Carpal Tunnel Syndrome
Interventions: OTHER: nerve flossing technique|OTHER: multimodal electrotherapy|OTHER: exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Zanubrutinib (BGB-3111) in Participants With Previously Treated B-Cell Lymphoma Intolerant of Prior Bruton Tyrosine Kinase Inhibitor (BTKi) Treatment
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma|Mantle Cell Lymphoma|Marginal Zone Lymphoma|Waldenstrom Macroglobulinemia
Interventions: DRUG: Zanubrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Study the Effect of Adding on Pegylated Interferon (PEG-INF) Therapy for Patients Diagnosed With Chronic Hepatitis B
Status: UNKNOWN
Conditions: Hepatitis B
Interventions: DRUG: PEG-IFN & Nucleos(t)tide analogues|DRUG: Nucleos(t)tide analogues
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of PEDI_ EAT 10 Score Versus Nurse Performed Screening in the Assessment of Post Extubation Dysphagia
Status: NOT_YET_RECRUITING
Conditions: Pediatric Post Extubation Dysphagia
Interventions: DEVICE: endotracheal tube
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of rTMS on Resting State Brain Activity in Tinnitus
Status: COMPLETED
Conditions: Tinnitus
Interventions: DEVICE: Sham rTMS - Sham repetitive transcranial magnetic stimulation|DEVICE: Active 1 Hz rTMS - Active repetitive transcranial magnetic stimulation delivered at 1 Hz frequency|DEVICE: Active 10 Hz rTMS - active repetitive transcranial magnetic stimulation delivered at 10 Hz frequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Olfactory Function and Olfactory Bulb Volume in Acromegaly Patients
Status: COMPLETED
Conditions: Acromegaly|Olfactory Disorder
Interventions: OTHER: OB volume|OTHER: CCCRC test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of Two Types of Absorbable Surgical Sutures in the Suturing of Thyroid Surgery Incision
Status: COMPLETED
Conditions: Sutures
Interventions: DEVICE: Spiral PDS Plus|DEVICE: Spiral MONOCRYL Plus|DEVICE: PDS Plus|DEVICE: MONOCRYL Plus|DEVICE: VICRYL Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of Stimulated ∆FGF19 for Diagnosing Bile Acid Diarrhoea
Status: COMPLETED
Conditions: Bile Acid Malabsorption
Interventions: DRUG: Oral chenodeoxycholic acid stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of LY01610 in Patients With Recurrent Small Cell Lung Cancer
Status: RECRUITING
Conditions: Relapsed Small Cell Lung Cancer
Interventions: DRUG: Irinotecan hydrochloride liposome Injection|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Oral Cyclophosphamide vs Doxorubicin in ≥65 Years Old Advanced or Metastatic Soft Tissue Sarcoma Patients
Status: RECRUITING
Conditions: Advanced Soft-tissue Sarcoma|Metastatic Soft-tissue Sarcoma
Interventions: DRUG: Doxorubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Corticosteroids With Placebo Versus Corticosteroids With Propranolol Treatment of Infantile Hemangiomas (IH)
Status: TERMINATED
Conditions: Hemangioma
Interventions: DRUG: Prednisolone (Corticosteroid)|DRUG: Propranolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging With [89Zr]Panitumumab-PET/MRI in Patients With Newly Diagnosed Colorectal Cancer
Status: WITHDRAWN
Conditions: Metastatic Colon Cancer
Interventions: DRUG: [89Zr]Panitumumab PET-MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study for GSK3862995B in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease
Status: RECRUITING
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK3862995B|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Macadamia Nut on Cardiometabolic Risk Factors
Status: COMPLETED
Conditions: Cardiovascular Risk Factor|Heart Diseases|Inflammation
Interventions: DIETARY_SUPPLEMENT: Macadamia Nut|DIETARY_SUPPLEMENT: Control Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Correlation Among Standing-sitting Sagittal Spinal Alignment, Paravertebral Muscle and Postoperative Clinical Outcomes in Patients With Adult Degenerative Scoliosis
Status: UNKNOWN
Conditions: Degenerative Scoliosis
Interventions: RADIATION: standard standing-sitting posteroanterior and lateral whole spine X-ray and lumbar MRI examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SHR-1316 Combined With Chemotherapy and Chest Radiotherapy in ES-SCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: Extensive-stage Small Cell Lung Cancer
Interventions: DRUG: SHR1316|DRUG: Carboplatin|DRUG: Etoposide|RADIATION: Radiation therapy|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Controlled Study of ONO-5334 in Postmenopausal Women With Osteopenia or Osteoporosis
Status: COMPLETED
Conditions: Osteoporosis|Osteopenia
Interventions: DRUG: ONO-5334|DRUG: ONO-5334|DRUG: ONO-5334|DRUG: ONO-5334|DRUG: ONO-5334
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Adaptive Treatment Strategy for Adolescent Depression
Status: COMPLETED
Conditions: Adolescent Depression
Interventions: DRUG: Fluoxetine|BEHAVIORAL: Increased Dose of Interpersonal Psychotherapy|BEHAVIORAL: Continue to Receive Initial Dose of Interpersonal Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Scoliosis-Specific Exercise on Lower Limb Biomechanics
Status: ACTIVE_NOT_RECRUITING
Conditions: Scoliosis Idiopathic
Interventions: OTHER: Conventional Physical Therapy Program|OTHER: Physiotherapeutic Scoliosis-Specific Exercise (Schroth)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Light Exposure Tracker Designed to Improve Circadian Rhythms - Aim 1
Status: RECRUITING
Conditions: Alzheimer's Disease|Mild Cognitive Impairment
Interventions: DEVICE: Light goggles|DEVICE: Orange glasses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Vocal Exercises With Straw on Aerodynamic Parameters of Voice (Pressure, Flow) in Dysodic Singers With Nodules
Status: UNKNOWN
Conditions: Dysodia|Vocal Disorders
Interventions: OTHER: Vocal work session with straw exercises|OTHER: Vocal work session with open mouth exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study To Investigate The Effectiveness Of Pregabalin For Management Of Patients Undergoing Total Hip Replacement
Status: TERMINATED
Conditions: Pain, Perioperative
Interventions: DRUG: Placebo|DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Interactive Tool for Informed Consent
Status: WITHDRAWN
Conditions: Informed Consent
Interventions: BEHAVIORAL: Intervention A: Questionnaire accuracy|BEHAVIORAL: Intervention B: Questionnaire speed of completion|BEHAVIORAL: Intervention C: Questionnaire Completion rate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Genetically Modified Haploidentical Natural Killer Cell Infusions for B-Lineage Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Lymphoblastic Leukemia, Acute
Interventions: BIOLOGICAL: NK Cell Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MAC Bipsectral Index Below 50 for Chronic Opioid User
Status: UNKNOWN
Conditions: Anesthesia
Interventions: OTHER: History for opioid use
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Optical Coherence Tomography for Screening and Diagnosis of Colorectal Precancerous and Malignant Polyps
Status: ACTIVE_NOT_RECRUITING
Conditions: Colon Cancer|Rectal Cancer|Cancer of the Rectum|Cancer of the Colon|Precancerous Polyp|Malignant Polyp
Interventions: DEVICE: Optical coherence tomography probe
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Stepped Care vs Center-based Cardiopulmonary Rehabilitation for Older Frail Adults Living in Rural MA
Status: RECRUITING
Conditions: Angina, Stable|Congestive Heart Failure|Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Stepped Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: XC8 in the Treatment of Patients With the Eosinophilic Phenotype of Bronchial Asthma
Status: COMPLETED
Conditions: Bronchial Asthma|Eosinophilic Asthma
Interventions: DRUG: XC8 100 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of a Probiotic and Postbiotic in Overweight Individuals
Status: RECRUITING
Conditions: Obesity|Abdominal Obesity
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Postbiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Early arthroscoPic Stabilization veRsus rehabilitatiOn of the Shoulder in Adolescents With a trauMatic First-time Anterior Shoulder Dislocation ePisode
Status: RECRUITING
Conditions: Shoulder Dislocation
Interventions: PROCEDURE: Arthroscopic stabilization|OTHER: Rehabilitation including a period of immobilization followed by physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Rotigotine for Treatment of Reducing Signs and Symptoms of Fibromyalgia in Adults.
Status: COMPLETED
Conditions: Fibromyalgia Syndrome
Interventions: DRUG: Rotigotine|DRUG: Rotigotine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical, Molecular and Functional Biomarkers for PROgnosis, Pathomechanisms and Treatment Strategies of COVID-19 (PROVID) - (PROVID-CAPNETZ)
Status: UNKNOWN
Conditions: COVID-19|Viral Pneumonia|Pneumonia Due to Streptococcus Pneumoniae|Bacterial Pneumonia|Pneumonia Due to H. Influenzae|Pneumonia, Organism Unspecified|Pneumonia in Diseases Classified Elsewhere|Pneumonia Due to Other Specified Infectious Organisms
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Phenotype and Omics Study of KCNQ2-related Epilepsy
Status: RECRUITING
Conditions: KCNQ2-related Epilepsy
Interventions: OTHER: Electrophysiological detection of KCNQ2 mutation|OTHER: Multi-modal brain image and EEG|OTHER: Omics testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety Study to Evaluate Daptomycin in Non-infected Adults Who Are Either on Hemodialysis or Continuous Ambulatory Peritoneal Dialysis (MK-3009-021)
Status: COMPLETED
Conditions: End-Stage Renal Disease
Interventions: DRUG: daptomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Collaboration to Promote Early Childhood Well Being in Families Experiencing Homelessness
Status: COMPLETED
Conditions: Families Experiencing Homelessness With Children Under 48 Months of Age
Interventions: BEHAVIORAL: Healthy Home|BEHAVIORAL: Attachment and Biobehavioral Catch-up Infant (6-24 months) and Toddler (24-48 months).|BEHAVIORAL: HealthySteps
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Genomic & Proteomic Analysis of Docetaxel & Capecitabine as Primary Chemo for Stage II-III Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: docetaxel & capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Delirium in Intensive Care by Melatonin
Status: COMPLETED
Conditions: Mechanically Ventilated Patients
Interventions: DRUG: MELATONIN (HIGH DOSE)|DRUG: MELATONIN (LOW DOSE)|DRUG: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: How Atorvastatin Affects the Gut Flora and Metabolomics?
Status: UNKNOWN
Conditions: Atherosclerotic Cardiovascular Disease
Interventions: DRUG: Atorvastatin 20 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Success Rate of Single Versus Two Visit Regenerative Treatment Protocol in Non Vital Mature Anterior Teeth
Status: UNKNOWN
Conditions: Pulp Necrosis|Periapical Lesion|Anterior Teeth
Interventions: PROCEDURE: Single visit pulp regeneration|PROCEDURE: Two visit pulp regeneration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interchangeability of Right Ventricle Longitudinal Shortening in Echocardiography
Status: COMPLETED
Conditions: Right Ventricle|Speckle Tracking|Strains|Cardiac Surgery
Interventions: OTHER: transthoracic echocardiography (TTE)|OTHER: transoesophageal echocardiography (TEE).
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Multidisciplinary Support to Access Living Donor Kidney Transplant (MuST AKT)
Status: RECRUITING
Conditions: Living Donor Kidney Transplantation
Interventions: BEHAVIORAL: MuST AKT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate Safety and Tolerability of BF-200 ALA (Ameluz®) for Photodynamic Therapy in the Treatment of the Expanded Field of Actinic Keratosis on Face and Scalp
Status: COMPLETED
Conditions: Actinic Keratosis|Keratosis, Actinic|Keratosis
Interventions: COMBINATION_PRODUCT: BF-200 ALA and red light LED lamp
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protein Intake and Step Reduction in Older Adults
Status: COMPLETED
Conditions: Aging|Muscle Loss
Interventions: DIETARY_SUPPLEMENT: Whey|DIETARY_SUPPLEMENT: Collagen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: FGF-23 (Fibroblast Growth Factor 23) Regulation in Chronic Kidney Disease
Status: COMPLETED
Conditions: Secondary Hyperparathyroidism
Interventions: DRUG: Sevelamer Carbonate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effects of Physical Exercise on Frailty, Mental and Physical Health of Older Adults in Rural Areas.
Status: RECRUITING
Conditions: Old Age|Frailty
Interventions: DEVICE: Face-to-face and video-assisted training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fruquintinib Combined With Sintilimab as Second-line Therapy for Gastric or Gastro-esophageal Junction Adenocarcinoma
Status: NOT_YET_RECRUITING
Conditions: Stomach Neoplasms
Interventions: DRUG: Fruquintinib|DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caffeine vs. ALA in BMS Treatment. (BMS: Burning Mouth Syndrome. ALA: Alpha-Lipoic Acid.)
Status: COMPLETED
Conditions: Caffeine|Burning Mouth Syndrome
Interventions: DIETARY_SUPPLEMENT: Caffeine|DRUG: Alpha Lipoic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Effect of Music in Patients Undergoing General Anesthesia
Status: COMPLETED
Conditions: Perioperative Anxiety|Postoperative Pain
Interventions: DEVICE: Music Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: GEOHealth Hub: Household Air Pollution and Cardio-pulmonary and Immune Function Outcomes
Status: UNKNOWN
Conditions: Household Air Polution|Cardiovascular Diseases|Lung Diseases|Immune Dysfunction
Interventions: DEVICE: Improved cook stove
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: SentiMag® Intraoperative Comparison in Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DEVICE: SiennaXP|DRUG: Technetium Tc99m Sulfur Colloid|DRUG: Isosulfan blue dye
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Deterioration in Body Posture of Older Patients During Gait Compared to Stance
Status: COMPLETED
Conditions: Degenerative Spine Disease|Sagittal Balance
Interventions: DIAGNOSTIC_TEST: Questionnaires and pain assessment|DIAGNOSTIC_TEST: Standing sagittal whole spine X-ray|DIAGNOSTIC_TEST: Dynamic test|DIAGNOSTIC_TEST: Muscle strength and body composition measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of BIBW 2992 (Afatinib) in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: DRUG: BIBW 2992|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibuprofen vs Acetaminophen for AMS Prevention
Status: COMPLETED
Conditions: Acute Mountain Sickness, Blood Oxygen Saturation, Headache
Interventions: DRUG: Ibuprofen|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Niraparib in the Treatment of Patients With Advanced PALB2 Mutated Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor|Breast Tumor|Colon Tumor, Malignant|Lung Tumor|Urologic Cancer|Pancreatic Cancer|Melanoma|Metastatic Cancer|Locally Advanced Solid Tumor|Esophageal Cancer|Endometrial Cancer|Head and Neck Cancer
Interventions: DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Completeness of Response" Following Treatment With Treximet™ for Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: sumatriptan succinate 85 mg/naproxen sodium 500 mg (Treximet)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optiflow THRIVE for Delivery of Oxygen to Patients During Total Intravenous Anesthesia While Undergoing Radiology Procedures
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: PROCEDURE: Oxygen Therapy|PROCEDURE: Oxygen Therapy|OTHER: Questionnaire Administration|DEVICE: Optiflow THRIVE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Immune Mobilization of Autologous Peripheral Blood Stem Cells Using Interleukin-2 and GM-CSF
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma|Hodgkin's Disease|Multiple Myeloma|Other Plasma Cell Dyscrasia (Waldenstrom, Amyloidosis)|Leukemia
Interventions: DRUG: GM-CSF|DRUG: IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lapatinib With Carboplatin and Paclitaxel in Esophagus and Gastroesophageal Junction (GEJ)
Status: TERMINATED
Conditions: Adenocarcinoma of the Esophagus|Adenocarcinoma of the Gastroesophageal Junction
Interventions: DRUG: Carboplatin AUC|DRUG: Paclitaxel|DRUG: lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-dose Ibuprofen Prophylaxis for IUD-insertion
Status: UNKNOWN
Conditions: Pelvic Pain|IUD
Interventions: DRUG: Ibuprofen|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Motor-Sparing Peripheral Nerve Blockade Facilitates Mobility Post Total Knee Arthroplasty: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Knee
Interventions: DRUG: Femoral nerve catheter and sciatic nerve block|DRUG: Adductor canal catheter and selective tibial block|DRUG: Adductor canal catheter only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Brief Potent Glutamatergic Modulation on Cocaine Dependence
Status: TERMINATED
Conditions: Cocaine Dependence
Interventions: DRUG: Ketamine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Mechanisms of Percutaneous Electrolysis
Status: COMPLETED
Conditions: Percutaneous Electrolysis|Pain|Analgesia|Pain Modulation|Endogenous Analgesia System
Interventions: OTHER: Sham intervention|OTHER: Low intensity percutaneous electrolysis|OTHER: High intensity percutaneous electrolysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Imotun Capsule in Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: Imotun|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison Between Two Techniques for Performing Decompressive Craniectomy
Status: COMPLETED
Conditions: Brain Edema|Craniocerebral Trauma|Infarction, Middle Cerebral Artery
Interventions: PROCEDURE: Without watertight duraplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Atorvastatin on Prevention of Postoperative Acute Kidney Injury in Patients Undergoing Aortic Surgery
Status: COMPLETED
Conditions: Aortic Surgery|Acute Kidney Injury
Interventions: DRUG: Atorvastatin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: AZD0530 to Treat Recurrent Stage IIIB/IV NSCLC Previously Treated With Combination Chemotherapy
Status: COMPLETED
Conditions: Recurrent Non-small Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: DRUG: saracatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of Theragun Percussion Therapy and Compression Therapy in The Patients With Migraine
Status: RECRUITING
Conditions: Migraine
Interventions: OTHER: THERAGUN PERCUSSION THERAPY|OTHER: COMPRESSION THERAPY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Raloxifene as an Adjuvant Treatment of the Negative Symptoms of Schizophrenia in Post-menopausal Women
Status: COMPLETED
Conditions: Schizophrenia in Post Menopausal Women
Interventions: DRUG: Raloxifene|DRUG: Lactosa (placebo arm)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Post-retained Restorations for RPD Abutments
Status: UNKNOWN
Conditions: Tooth, Nonvital|Composite Resins|Metal Ceramic Restorations|Denture, Partial, Removable|Post and Core Technique
Interventions: DEVICE: Glass-fiber post and composite resin restoration|DEVICE: Glass-fiber post and metalceramic crown|DEVICE: Cast-metal post and metalceramic crown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PersonaLized neoAdjuvant Strategy ER Positive and HER2 Negative Breast Cancer TO Increase BCS Rate
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Leuprorelin acetate|DRUG: Letrozole|GENETIC: MammaPrint
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Cognitive and Functional Decline Among Seniors at Risk
Status: COMPLETED
Conditions: Subjective Cognitive Decline
Interventions: BEHAVIORAL: Real World Strategy Training|BEHAVIORAL: Psychosocial Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oral Ibuprofen Prophylaxis for Patent Ductus Arterioses in Very Extremely Low Birth Weight Infants
Status: UNKNOWN
Conditions: Oral Ibuprofen Prophylaxis in Very Low Birth Weight Infants
Interventions: DRUG: ibuprofen|DRUG: ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Human Albumin Infusion in Liver Cirrhosis and Overt Hepatic Encephalopathy (HACHE)
Status: NOT_YET_RECRUITING
Conditions: Overt Hepatic Encephalopathy
Interventions: DRUG: Human albumin infusion at a modified dosage|DRUG: Human albumin infusion at a routine dosage|DRUG: Lactulose|DRUG: Rifaximin|DRUG: Ornithine Aspartate|DRUG: Branched-Chain Amino Acids|DRUG: Arginine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of the Safety and Efficacy of Inhaled Alpha-1 Antitrypsin (AAT ) in Cystic Fibrosis Patients
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Aerosolized, human, plasma-derived Alpha-1 Antitrypsin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Disaster Preparedness of Older People
Status: NOT_YET_RECRUITING
Conditions: Disaster|Older People
Interventions: BEHAVIORAL: Disaster Preparedness Education Program|OTHER: Disaster and Emergency Management Presidency Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of a COX-2 Inhibitor for Prevention of Ovulation
Status: UNKNOWN
Conditions: Rupture; Graafian Follicle
Interventions: DRUG: Meloxicam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Coagulation Faction VIIa Variant Marzeptacog Alfa (Activated) in Adult Subjects With Hemophilia
Status: COMPLETED
Conditions: Hemophilia A|Hemophilia B|Hemophilia A With Inhibitor|Hemophilia B With Inhibitor|Hemophilia A Without Inhibitor|Hemophilia B Without Inhibitor
Interventions: BIOLOGICAL: MarzAA (marzeptacog alfa [activated])
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Transcranial Magnetic Stimulation (rTMS) as a Tool to Decrease Pain and Improve Functioning
Status: TERMINATED
Conditions: Opioid Use Disorder
Interventions: DEVICE: repetitive Trans Magnetic Stimulation|DEVICE: Sham TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of MK0974 in the Acute Migraine (0974-016)
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: MK0974 50 mg|DRUG: MK0974 150 mg|DRUG: MK0974 300 mg|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Imaging (MRI) in Predicting Response to Sunitinib Malate in Patients With Locally Advanced or Metastatic Kidney Cancer
Status: COMPLETED
Conditions: Renal Cell Carcinoma|Stage III Renal Cell Cancer|Stage IV Renal Cell Cancer
Interventions: GENETIC: mutation analysis|OTHER: pharmacological study|PROCEDURE: dynamic contrast-enhanced magnetic resonance imaging|DRUG: sunitinib malate|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sub-tenon Triamcinolone Acetonide in Age-Related Macular Degeneration as Adjunct to Ranibizumab
Status: UNKNOWN
Conditions: Wet Macular Degeneration
Interventions: DRUG: Ranibizumab|DRUG: Triamcinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Diameters and Wall-to-lumen Ratio of Retinal Arterioles in Patients With Retinal Vein Occlusion.
Status: COMPLETED
Conditions: Hypertensive Patients With Retinal Vein Occlusion
Interventions: DEVICE: Dexamethasone Intravitreal Implant (Ozuredex)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Exposure of Taxi Drivers to Ultrafine Particles and Black Carbon Within Their Vehicles
Status: COMPLETED
Conditions: Pulmonary Ventilation
Interventions: OTHER: Exposure measurement|OTHER: Spirometry test|DIAGNOSTIC_TEST: Exhaled carbon monoxide test|DIAGNOSTIC_TEST: Skin allergy test|DIAGNOSTIC_TEST: Spirometry test|DIAGNOSTIC_TEST: Fractional Exhaled Nitric Oxide Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effects of Home-based Surface Electrical Stimulation for Patients With Cervical Myofascial Pain Syndrome
Status: RECRUITING
Conditions: Myofascial Pain Syndrome of Neck
Interventions: DEVICE: Surface electrical stimulation (SES)|OTHER: Remote medical support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Misoprostol for the Prevention of Postpartum Hemorrhage in Rural Pakistan
Status: COMPLETED
Conditions: Postpartum Hemorrhage|Anemia
Interventions: DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Therapeutic Effect of Electret Static Physiotherapy Film on Acute Soft Tissue Closed Injury
Status: COMPLETED
Conditions: Soft Tissue Injuries
Interventions: DRUG: Electret electrostatic physiotherapyFilm|DRUG: Fracture healing film
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MK0524A Phase IIb Study (0524A-011)(COMPLETED)
Status: COMPLETED
Conditions: Flushing
Interventions: DRUG: Comparator: niacin / Duration of Treatment: 17 Weeks|DRUG: MK0524A, niacin (+) laropiprant / Duration of Treatment: 17 Weeks|DRUG: Comparator: placebo (unspecified) / Duration of Treatment: 17 Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Examine the Clinical Value of Comprehensive Genomic Profiling Performed by Belgian NGS Laboratories: a Belgian Precision Study of the BSMO in Collaboration With the Cancer Centre
Status: RECRUITING
Conditions: Solid Tumor|Metastatic Cancer
Interventions: DIAGNOSTIC_TEST: Comprehensive genomic profiling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Fluoride in a Dentifrice on Remineralization of Erosive Lesions
Status: COMPLETED
Conditions: Enamel Erosion
Interventions: DRUG: sodium fluoride|DRUG: no added fluoride in a silica base
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Prevention of Erythropoietin on Cardiac Surgery-associated Acute Kidney Injury
Status: TERMINATED
Conditions: Acute Kidney Injury|Cardiac Disease|Surgery
Interventions: DRUG: Erythropoietin|DRUG: 0.9% sodium chloride|PROCEDURE: cardiac surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction (AMI)
Status: RECRUITING
Conditions: Acute Myocardial Infarction|Severe Periodontitis|Carotid Atherosclerosis
Interventions: OTHER: Periodontal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of PF-07263689 in Participants With Selected Advanced Solid Tumors
Status: TERMINATED
Conditions: Renal Cell Cancer|Melanoma|Non-Small-Cell Lung Cancer|Hepatocellular Cancer|Bladder Cancer|Sarcoma|Head and Neck Cancer|Colorectal Cancer|Ovarian Cancer|Squamous Cell Carcinoma
Interventions: BIOLOGICAL: PF-07263689|BIOLOGICAL: Sasanlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing Opioid Care Practices Using CPV Patient Simulation Modules
Status: COMPLETED
Conditions: Pain|Pain, Acute|Pain, Chronic|Pain, Neuropathic|Opioid-use Disorder|Opioid Abuse and Addiction|Opioid Withdrawal
Interventions: OTHER: Quality IQ Patient Simulations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Does Adding Magnesium Sulphate to Low Dose Rocuronium Affects Depth of Blockade
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: standard rocuronium dose|DRUG: Magnesium sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Construction and Application of Precise Health Education Model for Patients With PICC Tube
Status: COMPLETED
Conditions: Tumor Chemotherapy Patients
Interventions: BEHAVIORAL: Routine health education|BEHAVIORAL: Routine health education + precise health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: SINGLE-APPLICATION TERBINAFINE HYDROCHLORIDE (1%) TOPICAL LIQUID SOLUTION VERSUS A SINGLE-APPLICATION BUTENAFINE HYDROCHLORIDE (1%) TOPICAL LIQUID SOLUTION FOR THE TREATMENT OF TINEA PEDIS
Status: UNKNOWN
Conditions: Tinea Pedis
Interventions: DRUG: TERBINAFINE HYDROCHLORIDE (1%)|DRUG: BUTENAFINE HYDROCHLORIDE (1%)|DRUG: Vehicle Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Vascular Effects of Respiratory Rate & Carbon Dioxide
Status: WITHDRAWN
Conditions: Low Tidal Volume Ventilation|Acute Respiratory Distress Syndrome
Interventions: OTHER: HLR|OTHER: EHR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Clinical Study on the Safety and Efficacy of Debio 0932 in Combination With Standard of Care in Patients With Non-small Cell Lung Cancer [NSCLC]
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Debio 0932|DRUG: Cisplatin|DRUG: Pemetrexed|DRUG: Gemcitabine|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Examine Respiratory Combination Vaccines Against Respiratory Syncytial Virus (RSV) and Flu in Older Adults
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: RSVpreF+qIRV|BIOLOGICAL: qIRV|BIOLOGICAL: RSVpreF|DRUG: Placebo|BIOLOGICAL: RSVpreF + qIRV 1.0 mL formulation|BIOLOGICAL: RSVpreF + qIRV 0.5 mL formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Usability, Immediate, and 30 Day Effect of External Neuromodulation With iTEAR100 Generation 2 in Dry Eye Patients
Status: UNKNOWN
Conditions: Dry Eye
Interventions: DEVICE: iTEAR100 treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Quetiapine on Ultrastructural Hippocampal and Neurochemical Changes in Patients With Bipolar Disorder: Searching for Antidepressant and Mood Stabilising Neurophysiology
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Seroquel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Benefit of IL4RA Inhibition in Aspirin-Exacerbated Respiratory Disease
Status: RECRUITING
Conditions: Nasal Polyps|Asthma, Aspirin-Induced|Aspirin-Exacerbated Respiratory Disease|Aspirin-Sensitive Asthma With Nasal Polyps
Interventions: DRUG: Dupilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT