pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of SEA-CD40 Given With Other Drugs in Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma|Carcinoma, Non-Small- Cell Lung
Interventions: DRUG: SEA-CD40|DRUG: pembrolizumab (KEYTRUDA®)|DRUG: pemetrexed|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: BIOLOGICAL: filgrastim|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: leucovorin calcium|DRUG: methotrexate|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Brain Health Champion Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild Cognitive Impairment|Dementia, Mild|Subjective Cognitive Decline|At Risk for Cognitive Decline
Interventions: BEHAVIORAL: Brain Health Champion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Educational Intervention in the First 18 Months of Life to Prevent/Manage Obesity of Children After Gestational Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Gestational Diabetes|Overweight and Obesity
Interventions: BEHAVIORAL: Educational intervention|OTHER: Conventional treatment Guia de Practica Clinica IMSS-029-08
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: 68Ga-FAPI-LM3 PET/CT Imaging in Patients With FAP/SSTR2 Positive Disease and Compared With 18F-FDG
Status: RECRUITING
Conditions: SSTR2|FAP|Positron-Emission Tomography
Interventions: DIAGNOSTIC_TEST: 18F-FDG PET/CT, 68Ga-FAPI-LM3 PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Postoperative Outcome After Sevoflurane and Propofol Anaesthesia
Status: COMPLETED
Conditions: Postoperative Cognitive Dysfunction
Interventions: DRUG: sevoflurane|DRUG: propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pembrolizumab and Doxorubicin Hydrochloride or Anti-Estrogen Therapy in Treating Patients With Triple-Negative or Hormone Receptor-Positive Metastatic Breast Cancer
Status: COMPLETED
Conditions: Estrogen Receptor Negative|Estrogen Receptor Positive|HER2/Neu Negative|Progesterone Receptor Negative|Progesterone Receptor Positive|Stage IV Breast Cancer|Triple-Negative Breast Carcinoma
Interventions: DRUG: Anastrozole|DRUG: Doxorubicin Hydrochloride|DRUG: Exemestane|OTHER: Laboratory Biomarker Analysis|DRUG: Letrozole|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Community-University Approach to Preventing HIV
Status: WITHDRAWN
Conditions: HIV/AIDS and Infections|Drug Abuse|Adolescent Behavior|Drug Usage|Alcohol Use|Mental Health|Tobacco Use|HIV Testing
Interventions: DEVICE: Storytelling 4 Empowerment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: European Survey of Cardiovascular Disease Prevention, Diabetes and Chronic Kidney Disease (EUROASPIRE VI)
Status: RECRUITING
Conditions: Coronary Disease|Acute Coronary Syndrome|Unstable Angina|ST Elevation Myocardial Infarction|Non-ST Elevation Myocardial Infarction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vaginal Progesterone to Reduce the Risk of Another Preterm Birth
Status: COMPLETED
Conditions: Pregnancy
Interventions: DRUG: 8% progesterone vaginal gel|DRUG: Placebo Vaginal Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Low Dose Ketamine on Narcotic Consumption in Patients Undergoing Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Cholelithiasis
Interventions: DRUG: Ketamine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase Ib/II Study of MEDI4736 Evaluated in Different Combinations in Metastatic Pancreatic Ductal Carcinoma
Status: COMPLETED
Conditions: Metastatic Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: MEDI4736 in combination with nab-paclitaxel and gemcitabine|DRUG: MEDI4736 in combination with AZD5069
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Effectiveness Study of JUVÉDERM VOLUMA® XC Injectable Gel for Chin Augmentation
Status: COMPLETED
Conditions: Chin Retrusion
Interventions: DEVICE: JUVÉDERM VOLUMA® XC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Usability of the STELO Exoskeleton in People With Acquired Brain Injury and Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury|Acquired Brain Injury
Interventions: DEVICE: Stelo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optical-Coherence Tomography for the Non-invasive Diagnosis and Subtyping of Basal Cell Carcinoma
Status: UNKNOWN
Conditions: Basal Cell Carcinoma|Optical Coherence Tomography|Deep Learning|Artificial Intelligence
Interventions: DEVICE: Optical Coherence Tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Alterations in Muscle After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Neuromuscular electrical stimulation (NMES)|BEHAVIORAL: Standard Rehabilitation Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transauricular Vagus Nerve Stimulation Improves Postoperative Delirium in Elderly Patients
Status: RECRUITING
Conditions: Vagus Nerve Stimulation
Interventions: DEVICE: Transauricular Vagal Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ex-vivo Delivery of Rituximab to Prevent PTLD in EBV Mismatch Lung Transplant Recipients: A Pilot Trial
Status: UNKNOWN
Conditions: Epstein-Barr Virus Infections|Post-transplant Lymphoproliferative Disorder
Interventions: BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The NONA-LISA Trial
Status: RECRUITING
Conditions: Respiratory Distress Syndrome in Premature Infant
Interventions: DRUG: Isotonic saline|PROCEDURE: Less Invasive Surfactant Administration (LISA)|DRUG: Fentanyl|BEHAVIORAL: Non-pharmacological standard operating procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A New Model of Exercise Referral Scheme Before and After Bariatric Surgery for People With Obesity
Status: NOT_YET_RECRUITING
Conditions: Obesity|Quality of Life|Weight Loss
Interventions: BEHAVIORAL: Behavioral to reduce sedentary behvaior|BEHAVIORAL: Physical activity|PROCEDURE: Bariatric Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Chemotherapy on Intestinal Bacteria in Patients With Newly Diagnosed Breast Cancer
Status: COMPLETED
Conditions: Ductal Breast Carcinoma In Situ|Invasive Breast Carcinoma|Stage I Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer
Interventions: OTHER: Cytology Specimen Collection Procedure|OTHER: Laboratory Biomarker Analysis|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: DMSO for Prevention of Capsular Contraction in Alloplastic Breast Reconstruction
Status: UNKNOWN
Conditions: Breast Capsular Contracture|Dimethyl Sulfoxide
Interventions: DRUG: Dimethyl Sulfoxide|DRUG: Saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mensenchymal Stem Cell (MSC) Included in OrthADAPT Membrane for Rotator Cuff Tears Repair
Status: UNKNOWN
Conditions: Chronic Disease
Interventions: BIOLOGICAL: Mesenchymal Stem Cells (MSCs)|BIOLOGICAL: OrthADAPT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Hyperandrogenism in Type 1 Diabetes
Status: RECRUITING
Conditions: Type 1 Diabetes|Polycystic Ovary Syndrome|Hyperandrogenism|Hirsutism|Oligomenorrhea|Ovulation Disorder
Interventions: OTHER: Clinical hyperandrogenism assessment|DIAGNOSTIC_TEST: Total testosterone (ng/dL)|DIAGNOSTIC_TEST: A1c (%)|DIAGNOSTIC_TEST: Total cholesterol|OTHER: Body mass index (BMI) (kg/m2)|DIAGNOSTIC_TEST: Frequency of chronic vascular complications [n (%)]|DIAGNOSTIC_TEST: Polycystic ovary morphology|DIAGNOSTIC_TEST: Cardiovascular autonomic reflex tests (CARTs)|DIAGNOSTIC_TEST: Sex hormone-binding globulin (SHBG) (nmol/L)|DIAGNOSTIC_TEST: Dehydroepiandrosterone-sulphate (IQL) (ng/mL)|OTHER: Waist circumference (cm)|OTHER: Waist-to-hip ratio|OTHER: Body composition|DIAGNOSTIC_TEST: Mean glucose (mg/dL)|DIAGNOSTIC_TEST: Time in target range (hours)|DIAGNOSTIC_TEST: Time in hyperglycemia (hours)|OTHER: Insulin dose (UI/Kg)|OTHER: Insulin sensitivity|DIAGNOSTIC_TEST: High-density lipoprotein (HDL) (mg/dL)|DIAGNOSTIC_TEST: Low-density lipoprotein (LDL) (mg/dL)|DIAGNOSTIC_TEST: Triglycerides (mg/dL)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ARTDeCo Study: A Study of RO4995819 in Patients With Major Depressive Disorder And Inadequate Response to Ongoing Antidepressant Treatment
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Placebo|DRUG: RO4995819|DRUG: RO4995819|DRUG: RO4995819
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Documentation Physician Compensation Incentives
Status: COMPLETED
Conditions: Compensation Incentives|Clinical Documentation|Physician Work Environment|Diagnostic Error
Interventions: BEHAVIORAL: Compensation Incentives to improve Clinical Documentation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of the Cognitive and Motor Effects of Treatment Between an Immediate- and Extended-release Tacrolimus (Envarsus® XR) Based Immunosuppression Regimen in Kidney Transplant Recipients
Status: COMPLETED
Conditions: Kidney Transplant Failure and Rejection
Interventions: DRUG: immediate-release tacrolimus|DRUG: extended release tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atorvastatin as GVHD Prophylaxis for Allogeneic Hematopoietic Cell Transplantation
Status: COMPLETED
Conditions: Graft vs Host Disease
Interventions: DRUG: Atorvastatin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Catecholamine Concentrations in Venous Blood During Selective Adrenal Artery Embolization
Status: RECRUITING
Conditions: Resistant Hypertension|Secondary Hypertension|Secondary Hypertension to Endocrine Disorders|Primary Aldosteronism
Interventions: PROCEDURE: Selective adrenal artery embolization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Safety and Tolerability Study of Crenolanib in Combination With Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia Patients With FLT3 Mutations
Status: COMPLETED
Conditions: Newly Diagnosed AML With FLT3 Activating Mutations
Interventions: DRUG: crenolanib|DRUG: cytarabine|DRUG: daunorubicin|DRUG: idarubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Determine The Amount Of Voriconazole In The Brain After 2 Loading Doses And 3 Maintenance Doses Over 3 Days
Status: COMPLETED
Conditions: Infections, Fungal
Interventions: DRUG: voriconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Milrinone Inhaled in Cardiac Surgery
Status: COMPLETED
Conditions: Valvular Stenosis|Valvular Insufficiency|Hypertension, Pulmonary|Coronary Artery Disease
Interventions: DRUG: Milrinone|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate and Mycophenolate Mofetil for Steroid-Refractory Sclerotic/Fibrotic cGVHD in Children
Status: TERMINATED
Conditions: Chronic Graft-versus-host Disease
Interventions: DRUG: Imatinib mesylate, Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability and Pharmacokinetics of AVI-7288 in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Marburg Hemorrhagic Fever
Interventions: DRUG: AVI-7288|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Examining the Effectiveness of Exercise Training After Cervical Laminoplasty Surgery
Status: RECRUITING
Conditions: Cervical Spine Disease|Surgery|Rehabilitation|Exercise
Interventions: OTHER: Stabilization Exercises|OTHER: Standard Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of OEP on Rehabilitation Outcomes on TKR Patients
Status: NOT_YET_RECRUITING
Conditions: Total Knee Replacement
Interventions: OTHER: Otago Exercise Program|OTHER: General TKR pprotocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Immunogenicity Study of Heterologous Prime-Boost Ebola Vaccine Regimens in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: MVA-BN-filo|BIOLOGICAL: Ad26. ZEBOV|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: FirstStep2Health Intervention
Status: COMPLETED
Conditions: Pediatric Obesity|Risk Reduction Behavior|Early Intervention|Intergenerational Relations
Interventions: BEHAVIORAL: Caregiver Component.|BEHAVIORAL: Caregiver-Preschooler Learning.|BEHAVIORAL: Center-based Preschooler Component.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Histone Deacetylase Inhibitor (HDACi) Quisinostat (JNJ-26481585) in Patients With Previously Treated Stage Ib-IVa Cutaneous T-cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma, T-Cell, Cutaneous
Interventions: DRUG: Quisinostat, 12 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inter-arm and Inter-period Reproducability of the Dermal Blood Flow Response After a Histamine Skin Prick.
Status: COMPLETED
Conditions: Pruritus
Interventions: PROCEDURE: Histamine 10 mg/ml skin prick|PROCEDURE: Placebo (saline) skin prick
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of DTaP//PRP-T Combined Vaccine (ACTACEL) Versus Local DTaP and Act-HIB Monovalent Vaccine in Healthy Infants
Status: COMPLETED
Conditions: Diphtheria|Tetanus|Pertussis|Haemophilus Influenzae Type B
Interventions: BIOLOGICAL: DTaP//PRP-T Combined Vaccine|BIOLOGICAL: DTaP//PRP-T Combined Vaccine|BIOLOGICAL: DTaP Combined Vaccine and PRP-Tetanus Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Aquatic Intervention on Fall Risk, Hazard Perception, Calendar Planning and Brain Activity During Elderly
Status: COMPLETED
Conditions: Aging|Falling|Pedestrian Accidents|Physical Activity
Interventions: OTHER: Aquatic physical intervention|OTHER: On-land physical intervention|OTHER: Non physical intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Study Investigating the Efficiency and Complications Related to Two Different Procedures Used for the Preparation of Dentures Applied in Patients With Edentulous
Status: NOT_YET_RECRUITING
Conditions: Edentulous Maxilla
Interventions: DEVICE: CAD-CAM fabricated provisional prosthesis|DEVICE: DC (denture conversion) provisional prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Los Tres Paso: Neoadjuvant Palbociclib Monotherapy, Concurrent Chemoradiation Therapy, Adjuvant Palbociclib Monotherapy in Patients With p16INK4a Negative, HPV-Unrelated Head and Neck Squamous Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Palbociclib|DRUG: Cetuximab|DRUG: Cisplatin|RADIATION: Intensity-Modulated Radiation Therapy|PROCEDURE: Tumor biopsy|PROCEDURE: Peripheral blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Viscosupplementation and Corticosteroid Injections for Knee Osteoarthritis
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Hylan G-F 20 (Synvisc One)|DRUG: Methylprednisolone (Corticosteroid)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: An Integrated Program for the Treatment of First Episode of Psychosis
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder|Brief Psychotic Disorder|Psychotic Disorder NOS
Interventions: BEHAVIORAL: Integrated Treatment|BEHAVIORAL: Community Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Orbital Versus Rotational Atherectomy Effects On Coronary Microcirculation in PCI
Status: COMPLETED
Conditions: Coronary Artery Disease (CAD)
Interventions: DEVICE: Orbital Atherectomy System (OAS)|DEVICE: Rotablator Rotational Atherectomy System|PROCEDURE: Magnetic Resonance Imaging (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Repeated Exposure to Eltrombopag in Adults With Idiopathic Thrombocytopenic Purpura (REPEAT)
Status: COMPLETED
Conditions: Purpura, Thrombocytopaenic, Idiopathic
Interventions: DRUG: eltrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Consistency of Oscillometry and Spirometry Test Results in Patients With Confirmed or Suspected Asthma or COPD
Status: COMPLETED
Conditions: Asthma/ COPD
Interventions: DIAGNOSTIC_TEST: suspected asthma|DIAGNOSTIC_TEST: suspected COPD|DIAGNOSTIC_TEST: confirmed asthma|DIAGNOSTIC_TEST: confirmed COPD
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Dose-escalating Pilot Study of Orelabrutinib for Newly-diagnosed PCNSL
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Central Nervous System Lymphoma
Interventions: DRUG: Orelabrutinib|DRUG: Rituximab|DRUG: Methotrexate (MTX)|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Patients With Moderate to Severe Active Rheumatoid Arthritis Comparing Different Infusion Durations of RoActemra/Actemra (Tocilizumab) Treatment
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Valganciclovir and Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes
Status: COMPLETED
Conditions: Cytomegalovirus Retinitis|HIV Infections
Interventions: DRUG: Valganciclovir|DRUG: Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Addictive Potential of LCCs in Dual Users
Status: COMPLETED
Conditions: Tobacco Use Disorder|Dual Tobacco Use|Tobacco Dependence|Smoking|Smoking, Cigar|Smoking, Cigarette|Smoking, Tobacco
Interventions: OTHER: Flavored and unflavored little cigars/cigarillos (LCCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of C-CAR039 (Prizloncabtagene Autoleucel) in Patients With Relapsed/Refractory Large B-Cell Lymphoma
Status: RECRUITING
Conditions: Relapsed/Refractory Large B-Cell Lymphoma
Interventions: BIOLOGICAL: Prizloncabtagene autoleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bovine Colostrum for Preterm Newborns
Status: COMPLETED
Conditions: Enteral Feeding Intolerance|Necrotizing Enterocolitis|Late-Onset Neonatal Sepsis
Interventions: DIETARY_SUPPLEMENT: Bovine Colostrum|DIETARY_SUPPLEMENT: Preterm Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Partial Breast Irradiation (PBI) for Selected Patients With Early Invasive or Non-Invasive Breast Cancer
Status: COMPLETED
Conditions: Ductal Breast Cancer
Interventions: RADIATION: Partial Breast Irradiation using 32 Gy / 8 fractions|RADIATION: Partial Breast Irradiation using 36 Gy / 9 fractions|RADIATION: Partial Breast Irradiation using 40 Gy /10 fractions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Recurrent or Persistent Cervical Cancer
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: BIOLOGICAL: human papillomavirus 16 E7 peptide|PROCEDURE: in vitro-treated peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of STERIFY GEL in the Treatment of Periodontitis Following Scaling and Root Planing
Status: COMPLETED
Conditions: Parodontitis
Interventions: DEVICE: Sterify Gel|PROCEDURE: Scaling and root planing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Pimecrolimus Cream 1% on the Molecular and Cellular Profile of Adult Male Patients With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Pimecrolimus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phytoestrogen Supplementation in Postmenopausal Women
Status: COMPLETED
Conditions: Low Serum Lipid Levels
Interventions: DRUG: phytoestrogens|DRUG: phytoestrogens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability Study of INNO-406 to Treat Chronic Myeloid Leukemia or Acute Lymphocytic Leukemia
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia|Acute Lymphocytic Leukemia
Interventions: DRUG: INNO-406
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Total Intravenous Anesthesia and Balanced Anesthesia on Postoperative Lung Function
Status: COMPLETED
Conditions: Lung Function
Interventions: DRUG: propofol|DRUG: propofol|DRUG: remifentanil|DRUG: fentanyl|DRUG: Sevoflurane/Nitrous Oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lengthening Adalimumab Dosing Interval in Quiescent Crohn's Disease Patients
Status: UNKNOWN
Conditions: Crohn Disease in Remission|Crohn Disease
Interventions: OTHER: Lengthening adalimumab dosing interval
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Icotinib Combined With Whole Brain Radiotherapy in Treating Multiple Brain Metastases From Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer|Metastatic Cancer
Interventions: DRUG: Icotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of Goofice® (Elobixibat) in Patients With Chronic Constipation
Status: UNKNOWN
Conditions: Constipation
Interventions: DRUG: Goofice®|DRUG: Goofice® Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety Of HKI-272 (Neratinib) In Subjects With Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung|Lung Neoplasms
Interventions: DRUG: HKI-272
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methylnatrexone In Resectable Head and Neck Squamous Cell Carcinoma (MINK). A "Window of Opportunity" Pilot Study.
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Methylnaltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hepaxa Management of Non-alcoholic Fatty Liver Disease
Status: UNKNOWN
Conditions: Non-Alcoholic Fatty Liver Disease|Non Alcoholic Fatty Liver|NASH - Nonalcoholic Steatohepatitis
Interventions: DIETARY_SUPPLEMENT: Hepaxa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Ocrelizumab on Brain Innate Immune Microglial Cells Activation in MS Using PET-MRI With 18F-DPA714
Status: RECRUITING
Conditions: Multiple Sclerosis|Relapse|Primary Progressive Multiple Sclerosis
Interventions: DRUG: Ocrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Precision-targeted Transcranial Magnetic Stimulation in the Treatment of Primary Dystonia
Status: UNKNOWN
Conditions: Primary Dystonia|Transcranial Magnetic Stimulation
Interventions: DEVICE: Transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Food Study of Olanzapine Tablets 5 mg and Zyprexa® Tablets 5 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Olanzapine Tablets 5 mg|DRUG: Zyprexa® Tablets 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of the Safety and Efficacy of Hemacord HPC, Cord Blood in Subjects With Acute Ischemic Stroke
Status: UNKNOWN
Conditions: Acute Ischemic Stroke
Interventions: BIOLOGICAL: HPC, Cord Blood
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Temozolomide in Patients With MPPGL
Status: COMPLETED
Conditions: Pheochromocytoma, Metastatic|Paraganglioma, Malignant|Pheochromocytoma Malignant
Interventions: DRUG: Temozolomide capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exclusive Enteral Nutrition vs. Infliximab in Chinese CD Patients
Status: WITHDRAWN
Conditions: Crohn's Disease|Exclusive Enteral Nutrition|Infliximab|Mucosal Healing
Interventions: BIOLOGICAL: Infliximab|DIETARY_SUPPLEMENT: Exclusive Enteral Nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of Optical Genome Mapping for the Identification of Constitutional Genomic Variants in a Postnatal Cohort
Status: RECRUITING
Conditions: Developmental Disability|Intellectual Disability|Autism Spectrum Disorder|Congenital Anomaly|Fragile X Syndrome|Facioscapulohumeral Muscular Dystrophy 1
Interventions: OTHER: Standard of care genetic testing group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Liquid Versus Powder Protein Supplementation to Optimize Protein Intake After Bariatric Surgery
Status: COMPLETED
Conditions: Body Composition|Obesity|Protein Supplementation|Bariatric Surgery Candidate|Weight Loss
Interventions: DIETARY_SUPPLEMENT: High protein liquid formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Carotenoids Supplementation on Visual Function in Chinese Subjects
Status: NOT_YET_RECRUITING
Conditions: Vision Disorders
Interventions: DIETARY_SUPPLEMENT: Carotenoids supplementation|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Follow-On Study of Donanemab (LY3002813) With Video Assessments in Participants With Alzheimer's Disease (TRAILBLAZER-EXT)
Status: COMPLETED
Conditions: Alzheimer Disease|Dementia|Brain Diseases|Central Nervous System Diseases|Cognitive Impairment
Interventions: OTHER: No Intervention|DRUG: donanemab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apatinib and Etoposide as the Maintenance Therapy in Extensive-stage Small Cell Lung Cancer After First-line Chemotherapy
Status: UNKNOWN
Conditions: Extensive-stage Small Cell Lung Cancer|Lung Cancer
Interventions: DRUG: Apatinib, Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer
Status: RECRUITING
Conditions: Endocrine Tumors|Non-Small Cell Lung Cancer|Ovarian Cancer|Breast Cancer|Gastrointestinal/Genitourinary Cancers|Neuroendocrine Tumors|Multiple Myeloma
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Aldesleukin|BIOLOGICAL: Individual Patient TCR-Transduced PBL|DRUG: Pembrolizumab (KEYTRUDA )
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Fluid Resuscitation in Pediatric Burn Patients Using Crystalloids and With Albumin on Day Two.
Status: COMPLETED
Conditions: Burns
Interventions: BIOLOGICAL: 5% Albumin (human) Solution|DRUG: Paeds solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multimodal Retinal Imaging in the Detection and Follow-up of Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease|Alzheimer Dementia|Mild Cognitive Impairment|Dementia|Glaucoma|Age-Related Macular Degeneration|Diabetic Retinopathy
Interventions: DIAGNOSTIC_TEST: Non-invasive, multimodal retinal imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Topical Therapies in Post op Endoscopic Sinus Surgery Patients
Status: WITHDRAWN
Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: DRUG: Saline Nasal|DRUG: Budesonide Nasal|DRUG: Topical Antibacterial (Product)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Dexmedetomidine in the Acute Treatment of Electrical Storm
Status: RECRUITING
Conditions: Ventricular Tachycardia|Ventricular Arrhythmias|Ventricular Fibrillation|Recurrent Ventricular Tachycardia
Interventions: DRUG: Dexmedetomidine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Synergy Between morpHOlogical and inflammatoRy Evaluation in Predicting Long-term Coronary Plaque Progression
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Coronary Syndrome|Atherosclerosis|Inflammation|Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: coronary OCT|DIAGNOSTIC_TEST: 68GaDOTATATE PET/CTCA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Ability of Partial Inverse Agonist, Iomazenil, to Block Ethanol Effects in Humans
Status: ACTIVE_NOT_RECRUITING
Conditions: Active Ethanol and Active Iomazenil|Active Ethanol and Placebo Iomazenil|Placebo Ethanol and Active Iomazenil|Placebo Ethanol and Placebo Iomazenil|Alcohol Effect|Driving Under the Influence|Alcohol Impairment
Interventions: DRUG: Active Ethanol|DRUG: Active Iomazenil|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Cisplatin Plus Radiotherapy Compared to Cetuximab Plus Radiotherapy in Locally Advanced Head and Neck Cancer.
Status: COMPLETED
Conditions: Locally Advanced Head and Neck Cancer
Interventions: DRUG: cetuximab|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MR Guided Focused Ultrasound for Treatment of Neuropathic Pain
Status: COMPLETED
Conditions: Severe Neuropathic Pain Due to Radiculopathy or Radicular Injury|Spinal Cord Injuries|Phantom Limb Pain
Interventions: DEVICE: Experimental: ExAblate Transcranial treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Real-Time fMRI to Enhance Interventions That Change Delay Discounting
Status: RECRUITING
Conditions: Alcohol Use Disorder (AUD)
Interventions: BEHAVIORAL: Real Time Neurofeedback|BEHAVIORAL: "Idealized"/Sham Neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Compare the Similarity of a Combination Dapagliflozin/Metformin Tablet With the Two Drugs Administered Separately
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Dapagliflozin + Glucophage tablet fasted|DRUG: Dapagliflozin/metformin IR FDC tablet fasted|DRUG: Dapagliflozin + Glucophage tablet fed|DRUG: Dapagliflozin/metformin IR FDC tablet fed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Test How SB756050 Affects Subjects With Type 2 Diabetes Mellitus After 6 Days of Dosing.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: SB756050
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Acute Metabolic Effects of Melatonin Treatment
Status: COMPLETED
Conditions: Glucose Metabolism Disorders
Interventions: DRUG: Melatonin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety,Long-term Study of Low-dose Oral Contraceptive Pill to Treat Dysmenorrhea.
Status: COMPLETED
Conditions: Dysmenorrhea
Interventions: DRUG: Norethindrone,Ethinyl Estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeting the Conus Medullaris With ECAP-Controlled Closed-Loop SCS for Treatment of Chronic Pelvic Pain: HOPE Trial
Status: RECRUITING
Conditions: Chronic Pelvic Pain|Pudendal Neuralgia
Interventions: DEVICE: Saluda Evoke Smart SCS System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Solarplast for Health and Oxidative Stress
Status: COMPLETED
Conditions: Oxidative Stress|Healthy Aging|Skin Health
Interventions: DIETARY_SUPPLEMENT: Solarplast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Relationship Between Inflammatory ARTritis and CArdiac DIseAse
Status: ACTIVE_NOT_RECRUITING
Conditions: Inflammatory Arthritis|Rheumatoid Arthritis|Spondylitis, Ankylosing|Axial Spondyloarthritis|Spondyloarthritis|Heart Failure|Ischemic Heart Disease|Valvular Heart Disease|Left Ventricular Systolic Dysfunction|Heart Failure, Systolic|Heart Failure, Diastolic|Myocardial Infarction|Myocardial Dysfunction|Cardiac Disease|Stroke
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Registry Study of Thoracic Reirradiation for Non-Small Cell Lung Cancer (NSCLC) Utilizing Proton Beam Therapy or Intensity Modulated Radiation Therapy
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: OTHER: Thoracic Reirradiation Registry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK), and Preliminary Anticancer Activity of GSK4524101 Alone or With Niraparib in Participants With Solid Tumors
Status: RECRUITING
Conditions: Neoplasms
Interventions: DRUG: GSK4524101|DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Flow Oxygen VERSUS Non Invasive Ventilation Associated to Automated Flow Oxygen Titration After Patient Extubation
Status: COMPLETED
Conditions: Respiratory Disease
Interventions: DEVICE: High Flow Oxygen (HFO)|DEVICE: Non Invasive Ventilation (NIV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tachosil for the Prevention of Symptomatic Lymph Cysts
Status: COMPLETED
Conditions: Endometrial Cancer|Cervical Cancer
Interventions: DRUG: Tachosil fibrin patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Whole Body Examination by MRI Integrating the "Zero Time Eco" Sequence (ZTE, Pseudo-CT) for the Detection of Bone Lesions in Multiple Myeloma: Comparison With Pet / CT and Whole Body Scanner
Status: UNKNOWN
Conditions: Multiple Myeloma|Bone Metastases
Interventions: OTHER: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prospective Femoral Versus Femoral and Sciatic Nerve Block for Anterior Cruciate Ligament (ACL) Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Tear
Interventions: PROCEDURE: Sciatic Block|PROCEDURE: Femoral Block only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Anti-tetanus Neutralizing Antibody Titers and Safety of TNM002 Injection With Human Tetanus Immunoglobulin or Placebo in Adult Volunteers
Status: COMPLETED
Conditions: Tetanus
Interventions: BIOLOGICAL: TNM002 (low dose)|BIOLOGICAL: TNM002 (medium dose)|BIOLOGICAL: TNM002 (high dose)|BIOLOGICAL: HTIG|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: AUT-MENU: Improving Meal Experience of Subjects With Autism Spectrum Disorder
Status: NOT_YET_RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: OTHER: Administration of menus of collective catering adapted to the sensory and nutritional needs of subjects with Autism Spectrum Disorder|OTHER: Nutrition education course aimed at caregivers of individuals with Autism Spectrum Disorder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Telephone Educational Intervention by the Gastrointestinal Endoscopy Nurse. Global Impact on the Quality of Colonoscopy
Status: COMPLETED
Conditions: Colonic Diseases|Nurse-Patient Relations|Educational Problems
Interventions: OTHER: Educational telephone call
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Sunitinib Before and During Radiotherapy in Newly Diagnosed Biopsy-only Glioblastoma Patients
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: Sunitinib|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pentastarch Use in Cardiac Surgery
Status: UNKNOWN
Conditions: Cardiac Surgery|Cardiopulmonary Bypass
Interventions: DRUG: Pentastarch (displace either 500 ml or 1000 ml of pump prime with pentastarch)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Improving Understanding of Brain Tumors Through Preservation of Biologically Active Brain Tissue
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma
Interventions: DEVICE: NICO Myriad and Tissue Preservation System (TPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: The Effect of Therapeutic Methods for Chronic Knee Osteoarthritis Pain
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: radiofrequency neurotomy for genicular nerve|PROCEDURE: radiofrequency neurotomy sham therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Different PEEP Titration Strategies Using Electrical Impedance Tomography in Patients With ARDS
Status: COMPLETED
Conditions: ARDS (Acute Respiratory Distress Syndrome)|Electrical Impedance Tomography (EIT)|Positive End Expiratory Pressure (PEEP)|Acute Lung Injury
Interventions: OTHER: Ventilation strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RItuximab From the FIRst Episode of Idiopathic Nephrotic Syndrome
Status: UNKNOWN
Conditions: Minimal Change Nephrotic Syndrome (MCNS)
Interventions: DRUG: Rituximab|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy For Locally Advanced Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Locally Advanced Breast Cancer
Interventions: PROCEDURE: Sentinel Lymph Node Biopsy (SLNB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Vepoloxamer in Chronic Heart Failure
Status: TERMINATED
Conditions: Chronic Heart Failure
Interventions: DRUG: Vepoloxamer|OTHER: 5% dextrose in water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OMEGA, Local Ablative Therapy in Oligometastatic NSCLC
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: PROCEDURE: Surgical removal of primary and/or of all oligometastases|RADIATION: Non-surgical LAT|DRUG: Standard medical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Polymyxin-B Protects on Sepsis Induced Kidney Dysfunction: a Randomized Clinical Trial
Status: COMPLETED
Conditions: Gram-Negative Bacterial Infections|Sepsis
Interventions: DEVICE: Polymyxin -B fiber hemoperfusion system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION