pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluation of PCV Schedules in a Naive Population in Vietnam
Status: COMPLETED
Conditions: Pneumonia, Pneumococcal
Interventions: BIOLOGICAL: PCV 2p+1|BIOLOGICAL: PCV 3p+0|BIOLOGICAL: PCV 1p+1|BIOLOGICAL: PCV 0p+1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: European Trial of Dronedarone in Moderate to Severe Congestive Heart Failure
Status: TERMINATED
Conditions: Congestive Heart Failure
Interventions: DRUG: Dronedarone (SR33589)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Meningococcal ACWY Immune Response in Children Aged 40 and 60 Months
Status: COMPLETED
Conditions: Meningococcal Disease
Interventions: BIOLOGICAL: MenACWY-CRM197|BIOLOGICAL: Blood test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Expanded Access for the Treatment of Cancers With Rearranged During Transfection (RET) Activation
Status: AVAILABLE
Conditions: Non Small Cell Lung Cancer|Medullary Thyroid Cancer|Colon Cancer|Breast Cancer|Pancreatic Cancer|Papillary Thyroid Cancer|Other Solid Tumors With Evidence of Activating RET Alteration
Interventions: DRUG: Selpercatinib
Study Type: EXPANDED_ACCESS
Clinical trial: Sequentional Immuno Apheresis Plasma Volume Escalation Cohort Study of Reduction of Soluble Tumor Necrosis Factor Receptors 1 and 2 (sTNFR1/2) With or Without Nivolumab in Patients With Inoperable or Metastatic Solid Tumors
Status: UNKNOWN
Conditions: Stage IV Non-small Cell Lung Cancer|Stage IV Melanoma|Triple Negative Breast Cancer|Renal Cell Carcinoma Stage IV
Interventions: COMBINATION_PRODUCT: ImmunicomAIAC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypofractionated Stereotactic Irradiation With Nivolumab, Ipilimumab and Bevacizumab in Patients With Recurrent High Grade Gliomas
Status: COMPLETED
Conditions: Malignant Glioma
Interventions: RADIATION: Hypofractionated Stereotactic Irradiation|DRUG: Nivolumab|DRUG: Bevacizumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Dorzagliatin on 1st Phase Insulin and Beta-cell Glucose Sensitivity in T2D and Monogenic Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Dorzagliatin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Testing VS-6063 (Defactinib) as a Potential Targeted Treatment in Cancers With NF2 Genetic Changes (MATCH-Subprotocol U)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lymphoma|Advanced Malignant Solid Neoplasm|Hematopoietic and Lymphoid Cell Neoplasm|Refractory Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Multiple Myeloma
Interventions: DRUG: Defactinib Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erlotinib Is Being Studied With Or Without An Investigational Drug, PF-02341066, In Patients With Lung Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Erlotinib|DRUG: Erlotinib|DRUG: PF-02341066
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Blood Pressure and Cholesterol Targets for Preventing Recurrent Stroke in Hypertensives
Status: COMPLETED
Conditions: Stroke|Transient Ischemic Attack|Hypertension
Interventions: DRUG: all approved antihypertensive drugs; all approved statins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Benchmark Evidence Led by Latin America: Trial of Intracranial Pressure - Pediatrics
Status: RECRUITING
Conditions: Severe Traumatic Brain Injury
Interventions: OTHER: ICP|OTHER: CREVICE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficacy Between Suggestion Method During Video EEG Recording by Verbal Suggestion in Isolation and Verbal Suggestion Along With Cotton Swab or Tuning Fork for Inducing the Paroxysmal Event in Children Aged 5 to 18 Years With Suspected Psychogenic Nonepileptic Events
Status: UNKNOWN
Conditions: EEG, Psychogenic Non Epileptic Events
Interventions: DIAGNOSTIC_TEST: Video EEG with verbal suggestion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Efficacy and Cost Effectiveness of Preoperative and Postoperative Cryotherapy in Proximal Tibia Fractures
Status: TERMINATED
Conditions: Proximal Tibia Fracture
Interventions: DEVICE: Cryotherapy|DEVICE: Room temperature cuff
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Clinical Trial to Evaluate the Immunogenicity and Reactogenicity of the Recombinant HIV-1 Envelope Vaccines SF-2 rgp120 (CHO) [Chiron Vaccines] in MF59 Adjuvant and MN rgp120/HIV-1 [VaxGen] in Alum Adjuvant in Healthy Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: rgp120/HIV-1MN|BIOLOGICAL: rgp120/HIV-1 SF-2
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Phase 1/2 Study of [225Ac]-FPI-1434 Injection
Status: RECRUITING
Conditions: Advanced Solid Tumours|Endometrial Cancer|Cervical Cancer|Ovarian Cancer|Breast Cancer|Triple Negative Breast Cancer (TNBC)|HER2-negative Breast Cancer|Head and Neck Squamous Cell Carcinoma (HNSCC)|Adrenocortical Carcinoma|Uveal Melanoma
Interventions: DRUG: [111In]-FPI-1547 Injection|DRUG: [225Ac]-FPI-1434 Injection multi-dose|BIOLOGICAL: FPI-1175 Infusion|DRUG: [225Ac]-FPI-1434 Injection single-dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Convalescent Antibodies Infusion in COVID 19 Patients
Status: WITHDRAWN
Conditions: Pneumonia, Viral|Corona Virus Infection
Interventions: BIOLOGICAL: Anti-coronavirus antibodies (immunoglobulins) obtained with DFPP form convalescent patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Protein Intake of the Pregnant Woman According to the Weight Status and in Pregnant Women Operated on Bariatric Surgery
Status: UNKNOWN
Conditions: Pregnant Women From 20 Amenorrhea Weeks
Interventions: OTHER: food diary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Phase I Open-Label Study of Recombinant DNA Plasmid Vaccine, VRC-AVIDNA036-00-VP, Encoding for Influenza Virus H5 Hemagglutinin Protein Given Intradermally
Status: COMPLETED
Conditions: Influenza A Virus, H5N1 Subtype|Influenza A Virus|Influenzavirus A|Orthomyxovirdae|H5N1 Virus
Interventions: DRUG: VRC-AVIDNA036-00-VP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Appropriate Oxygen Levels for Extremely Preterm Infants: a Prospective Meta-analysis
Status: COMPLETED
Conditions: Infant, Premature, Diseases|Bronchopulmonary Dysplasia|Retinopathy of Prematurity|Infant, Newborn, Diseases|Infant, Very Low Birth Weight
Interventions: PROCEDURE: Higher oxygen saturation target range (91%-95%)|PROCEDURE: Lower oxygen saturation (85%-89%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Measuring Dietary Iron Absorption From Edible Insects and Assessing the Effect of Chitin Content on Iron Bioavailability (Study 1)
Status: COMPLETED
Conditions: Iron-deficiency
Interventions: OTHER: Refined maize with extrinsic addition of labelled FeSO4|OTHER: T.molitor native chitin|OTHER: T molitor reduced chitin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Pilot Study Comparing Effects of Xanomeline Alone to Xanomeline Plus Trospium
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: xanomeline tartrate|DRUG: Trospium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Repaglinide in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: repaglinide|DRUG: glyburide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prognostic Biomarkers in Samples From Young Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: GENETIC: protein expression analysis|GENETIC: western blotting|OTHER: flow cytometry|OTHER: laboratory biomarker analysis|OTHER: medical chart review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Study on the Noninvasive Lung Fluid Monitoring System in Guiding the Treatment of Heart Failure
Status: NOT_YET_RECRUITING
Conditions: Heart Failure
Interventions: DEVICE: ReDS-Guided|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Validation of a Therapeutic Decision Aid in Ectopic Pregnancy: GEUDECID Study
Status: NOT_YET_RECRUITING
Conditions: To Validate a Decision Aid for Ectopic Pregnancy
Interventions: OTHER: Therapeutic decision tool
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: DAYBREAK: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway
Status: ACTIVE_NOT_RECRUITING
Conditions: Genetic Obesity
Interventions: DRUG: Setmelanotide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cetuximab in Treating Patients With Persistent or Recurrent Cervical Cancer
Status: COMPLETED
Conditions: Cervical Squamous Cell Carcinoma|Recurrent Cervical Carcinoma
Interventions: BIOLOGICAL: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single and Multiple Dose Asian Bridging Study
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: E5501|DRUG: E5501|DRUG: E5501|DRUG: E5501
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Aripiprazole Long-acting on Myelin and Cognition in the Onset of Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia|Myelin Degeneration|Cognition Disorder
Interventions: DRUG: Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of G17DT Immunogen Combined With Gemcitabine vs. Gemcitabine in the Treatment of Advanced Pancreatic Carcinoma
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: G17DT Immunogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Cardiovascular Complications in Diabetic Patients With Vitamin E Treatment
Status: TERMINATED
Conditions: Diabetes|Myocardial Infarction|Cardiovascular Disease
Interventions: DRUG: Natural source Vitamin E 400IU/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Open-Label Rollover Study for Continuing Valbenazine Administration for the Treatment of Chorea Associated With Huntington Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Chorea, Huntington
Interventions: DRUG: Valbenazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Nasal Taper-guard Cuffed and a Nasal Cylindrical Endotracheal Tube
Status: COMPLETED
Conditions: Endotracheal Tube|Cuff Pressure
Interventions: DEVICE: TaperGuard endotracheal tube|DEVICE: cylindrical endotracheal tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Ketamine as Sedative Agent in Endoscopic Retrograde Cholangiopancreatography (ERCP)
Status: RECRUITING
Conditions: Ketamine Adverse Reaction
Interventions: DRUG: Ketamine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Combination Study of Antibiotics With Enzalutamide (PROMIZE)
Status: RECRUITING
Conditions: Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Interventions: DRUG: Enzalutamide 40mg|DRUG: Amoxicillin 500mg|DRUG: Metronidazole 400mg|DRUG: Vancomycin 125mg|DRUG: Ciprofloxacin 500g
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Psychological and Motor Effects of Testosterone in Adolescents With XXY/Klinefelter Syndrome
Status: COMPLETED
Conditions: Klinefelter Syndrome|XXY Syndrome
Interventions: DRUG: Testosterone gel 1%|DRUG: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PAZIT Study for Children and Young Adults With Relapsed or Refractory Sarcoma
Status: COMPLETED
Conditions: Sarcoma|Refractory Sarcoma
Interventions: DRUG: Pazopanib|DRUG: Irinotecan|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Biliary Drainage in Patients With Operable Malignant Periampulary Tumors
Status: COMPLETED
Conditions: Periampullary Cancer|Biliary Obstruction|Preoperative Biliary Drainage
Interventions: PROCEDURE: Preoperative Biliary Drainage (PBD)|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Cabazitaxel vs. Vinflunine in Metastatic or Locally Advanced Transitional Cell Carcinoma of the Urothelium (TCCU)
Status: UNKNOWN
Conditions: Urothelium Transitional Cell Carcinoma
Interventions: DRUG: Cabazitaxel|DRUG: Vinflunine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sterile Inflammation and Molecular Aberrations in MDS
Status: UNKNOWN
Conditions: Myelodysplastic Syndromes
Interventions: DIAGNOSTIC_TEST: Next Generation Sequencing|DIAGNOSTIC_TEST: Tumorimmunological examinations - multiplex assays/quantitative polymerase chain reaction|DIAGNOSTIC_TEST: flow cytometry|DIAGNOSTIC_TEST: Metagenomics of stool samples|DIAGNOSTIC_TEST: Clinical/demographic data|OTHER: Elicitation of the HRQoL
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Caelyx in Ovarian Cancer: Prevention and Treatment of Infusion Reactions and Palmar-plantar Erythrodysesthesia (Study P04085)(COMPLETED)
Status: COMPLETED
Conditions: Ovarian Neoplasms
Interventions: DRUG: Caelyx (Pegylated Lyposomal Doxorubicin)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Romosozumab vs. Zoledronic Acid Effect in Patients With Spinal Cord Injury and Low Bone Mineral Density
Status: UNKNOWN
Conditions: Osteoporosis Fracture|Spinal Cord Injuries
Interventions: DRUG: Romosozumab|DRUG: Zoledronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Recurrent Use of MSIR, Percocet, and Vicodin at Discharge From the ED
Status: WITHDRAWN
Conditions: Pain
Interventions: DRUG: Morphine Sulfate Immediate Release|DRUG: Oxycodone/Acetaminophen|DRUG: Hydrocodone/Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Psychological Interventions in Psycho-neuroendocrine-immune Network in Breast Cancer Survivors
Status: RECRUITING
Conditions: Breast Cancer Female|Breast Cancer Stage I|Breast Cancer Stage II|Breast Cancer Stage III
Interventions: BEHAVIORAL: Mindfulness-Based Cognitive Therapy (MBCT-Ca) - online|BEHAVIORAL: Positive Psychology - online|BEHAVIORAL: Autogenic Training - online
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: G-IVF and Sperm Parameters
Status: NOT_YET_RECRUITING
Conditions: Infertility, Male
Interventions: DEVICE: G-IVF PLUS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Ketamine on Immune Function and Prognosis in Patients Undergoing Colorectal Cancer Resection
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: Ketamine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Safety and Effectiveness Study of a Single Dose of JNJ-17216498 in Patients With Narcolepsy
Status: COMPLETED
Conditions: Narcolepsy
Interventions: DRUG: JNJ-17216498|DRUG: JNJ-17216498|DRUG: Modafinil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Pregabalin for Post-operative Pain in Women Undergoing Abdominal Hysterectomy
Status: COMPLETED
Conditions: Postoperative Pain|Opioid Use
Interventions: DRUG: Pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Ranging Study in Treatment Naive Type 2 Diabetes Mellitus(T2DM)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: GSK189075|DRUG: pioglitazone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Leuprolide to Treat Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Leuprolide acetate - Formulation A|DRUG: Leuprolide acetate - Formulation B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cow Milk Allergy: Evaluation of the Efficacy of a New Thickened Extensively Hydrolyzed Formula in Infants With Confirmed Cow Milk Allergy
Status: COMPLETED
Conditions: Cow Milk Allergy
Interventions: DIETARY_SUPPLEMENT: Extensively Hydrolyzed formula
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Piezoelectric Split-crest Technique Versus Expansion Using Hand Driven Ridge Expanders in Treatment of Maxillary Narrow Ridges
Status: UNKNOWN
Conditions: Edentulous Alveolar Ridge
Interventions: DEVICE: piezoelectric
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxytocin Effects on Likeability After Being Liked or Disliked
Status: COMPLETED
Conditions: Social Behavior
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interventions to Support Long-Term Adherence aNd Decrease Cardiovascular Events Post-Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction|Coronary Disease
Interventions: BEHAVIORAL: Usual care + letters|BEHAVIORAL: Usual care + letters + automated calls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Comparison Between Pupillometry, Heart Rate Variability and Metaiodobenzylguanidine Scintigraphy for the Diagnosis of Early Diabetic Autonomic Neuropathy in Type 1 Diabetes
Status: UNKNOWN
Conditions: Autonomic Neuropathy
Interventions: RADIATION: metaiodobenzylguanidine scintigraphy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Kinetics, Efficacy and Safety of C1-Esteraseremmer-N
Status: COMPLETED
Conditions: Hereditary Angioedema Type I|Angioneurotic Edema
Interventions: DRUG: C1 inhibitor concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of Bumetanide for Newborn Seizures
Status: COMPLETED
Conditions: Seizures
Interventions: DRUG: Bumetanide|DRUG: Normal Saline as Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Tolerability of AZD1152 in Combination With Low Dose Cytosine Arabinoside (LDAC)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: AZD1152|DRUG: LDAC (low dose cytosine arabinoside)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Skin Irritation Potential of PBI-100 Topical Cream in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: PBI-100 Topical Cream|DRUG: Positive Control - Sodium laurel sulfate (SLS)|OTHER: PBI-100 Topical Cream, Vehicle|OTHER: Negative Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Acupuncture in Infantile Colic - a Three Armed Randomized Multi Center Trial (ACU-COL)
Status: COMPLETED
Conditions: Infantile Colic
Interventions: OTHER: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial on the Effectiveness of Screening and Brief Problem-Solving Therapy (PST) for Elderly Patients With Psychological Problems
Status: COMPLETED
Conditions: Undiagnosed Psychological Problems
Interventions: BEHAVIORAL: problem-solving therapy|BEHAVIORAL: Video-viewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Foam Rolling Versus Stretching Exercises on Quadriceps, Hamstrings and Calf Muscle Length
Status: COMPLETED
Conditions: Muscle Tightness
Interventions: OTHER: Foam rolling|OTHER: Stretching exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Addition of X4P-001 to Nivolumab Treatment in Participants With Renal Cell Carcinoma
Status: TERMINATED
Conditions: Clear Cell Renal Cell Carcinoma
Interventions: DRUG: X4P-001|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Non-Specific Neck Pain Treated With Tai Chi and Chiropractic Care
Status: RECRUITING
Conditions: Neck Pain|Chronic Pain
Interventions: OTHER: Chiropractic Care|OTHER: Tai Chi|OTHER: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Breathing and Relaxation Exercises on Serum Cortisol Levels in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus|Stress
Interventions: BEHAVIORAL: Aerobic exercise|BEHAVIORAL: breathing exercise|BEHAVIORAL: Relaxation training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Tidal Model-Based Psychiatric Nursing Approach on Mothers of Children With Autism Spectrum Disorder
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: OTHER: Tidal Model-based psychiatric nursing approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Single Dose Intravenous Antibiotics for Complicated Urinary Tract Infections in Children
Status: RECRUITING
Conditions: Complicated Urinary Tract Infection|Infection|Pediatric Infectious Disease
Interventions: DRUG: Benzylpenicillin - single dose|DRUG: Benzylpenicillin - three days|DRUG: Gentamicin - single dose|DRUG: Gentamicin - three days|DRUG: Cefalexin - post single dose of IV antibiotics for the remaining two days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iron Bioavailability From Biofortified Orange-fleshed Sweet Potato
Status: COMPLETED
Conditions: Iron-deficiency|Iron Deficiency Anemia
Interventions: OTHER: High Fe OFSP meal labelled with Fe-58|OTHER: Control OFSP meal labelled with Fe-57
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Medical Service by Socio-aesthetics in Oncology
Status: NOT_YET_RECRUITING
Conditions: Cancer of Colon|Cancer, Lung|Cancer, Breast|Cancer Prostate|Cancer Pain|Anxiety Depression
Interventions: OTHER: SOCIO-AESTHETICS care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gemcitabine Hydrochloride and Cisplatin With or Without Bevacizumab in Treating Patients With Advanced Urinary Tract Cancer
Status: COMPLETED
Conditions: Advanced Urothelial Carcinoma|Metastatic Bladder Urothelial Carcinoma|Metastatic Prostate Carcinoma|Metastatic Renal Pelvis Urothelial Carcinoma|Metastatic Ureter Urothelial Carcinoma|Metastatic Urethral Urothelial Carcinoma|Metastatic Urothelial Carcinoma|Stage IV Bladder Urothelial Carcinoma AJCC v7|Stage IV Prostate Cancer AJCC v7|Stage IV Renal Pelvis Cancer AJCC v7|Stage IV Ureter Cancer AJCC v7|Stage IV Urethral Cancer AJCC v7|Unresectable Urothelial Carcinoma
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Cisplatin|DRUG: Gemcitabine Hydrochloride|OTHER: Laboratory Biomarker Analysis|OTHER: Placebo Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PK/PD of Vaping THC-containing Liquids vs. Smoked Cannabis
Status: NOT_YET_RECRUITING
Conditions: Cigarette Smoking-Related Carcinoma
Interventions: BEHAVIORAL: Vape device|BEHAVIORAL: Joint|DRUG: Marijuana via vape device|DRUG: Marijuana via joint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Gestational Diabetes: Insulin or Oral Hypoglycemic Agents?
Status: COMPLETED
Conditions: Gestational Diabetes Mellitus
Interventions: DRUG: Insulin|DRUG: Metformin, glyburide and insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 3-fold Crossover Bioequivalence Study Between Glucobay ODT (Orally Disintegrating Tablet) 100 mg and Glucobay Standard Tablet 100 mg
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Acarbose (Glucobay ODT, BAYG5421)|DRUG: Acarbose (Glucobay, BAYG5421)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Study of HLX06, a Humanized Monoclonal Antibody Targeting Human Vascular Endothelial Growth Factor Receptor-2 in Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Solid Tumor, Adult
Interventions: DRUG: HLX06
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melatonin in Patients With Multiple Sclerosis (MS).
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: 3 mg Melatonin|DRUG: 5 mg Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Ashwagandha Extract (Capsule KSM-66 300 mg) in Improving Sexual Health in Healthy Men
Status: RECRUITING
Conditions: Sexual Health
Interventions: DIETARY_SUPPLEMENT: Ashwagandha|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study on Optimised Removal of Protein-bound Uremic Toxins With Convective Dialysis Treatment.
Status: COMPLETED
Conditions: Chronic Renal Failure
Interventions: PROCEDURE: Performance of predilution hemofiltration, predilution hemodiafiltration or postdilution hemodiafiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics Study of BI 1744 CL in Healthy Male Subjects
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: BI 1744 CL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Validation of PET-MRI for Cardiovascular Disease
Status: COMPLETED
Conditions: MRI|PET Scan|Positron-Emission Tomography|Cardiovascular Disease|Coronary Artery Disease|Magnetic Resonance Imaging
Interventions: OTHER: PET/MR scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Horse Assisted Rehabilitation Postoncologic Treatment in Children and Adolescents: Physical and Psychological Effects
Status: UNKNOWN
Conditions: Cancer|Child, Only|Child Behavior|Neurologic Gait Disorder|Neurologic Complication
Interventions: OTHER: Horse-Assisted Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Whole Body Vibration in Different Devices on Bone and Muscle Mass in Postmenopausal Women
Status: RECRUITING
Conditions: Bone Density|Muscles|Physical Functional Performance|Accidental Falls|Quality of Life
Interventions: DEVICE: Triplanar vibrating platform|DEVICE: Side-alternating vibrating platform|OTHER: Sham vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Applying Streaming Media on Reducing Pain in Patient With Second-degree Burn During Changing Dressing
Status: NOT_YET_RECRUITING
Conditions: Burns|Pain, Burning|Anxiety
Interventions: BEHAVIORAL: Streaming Media
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Aminopterin Dose Finding Treatment for Methotrexate-Naïve Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: LD-aminopterin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Drug Interaction of HRS-1780 Tablets, Henagliflozin Tablets, Metformin Tablets and HRS-7535 Tablets in Healthy Human
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: HRS-1780 tablets|DRUG: HR20033 tablets|DRUG: HRS-7535 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Outcomes of a Non-Pharmacological Intervention for Neonatal Abstinence Syndrome
Status: COMPLETED
Conditions: Neonatal Abstinence Syndrome
Interventions: DEVICE: Stochastic Vibrotactile Stimulation (SVS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of De-Stress & Snooze Gummies in Reducing Stress and Insomnia Disorder
Status: NOT_YET_RECRUITING
Conditions: Stress|Insomnia|Quality of Life
Interventions: OTHER: De-Stress & Snooze Gummies-U001|OTHER: De-Stress & Snooze Gummies-I001|OTHER: Placebo Gummies 002
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Paclitaxel and Carboplatin With or Without Nitroglycerin in Treating Patients With Previously Untreated Stage III or Stage IV Non-Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: nitroglycerin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Single Dose Study to Determine the Excretion, Balance and Metabolic Disposition of Radiolabelled GW642444.
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: [14C]GW642444
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: the Impact of Manual or Mechanical Ways to Perform PLR on the Accuracy of Evaluation of Fluid Responsiveness
Status: RECRUITING
Conditions: Circulatory Failure
Interventions: DEVICE: Automatic Bed|DEVICE: Manual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Thiazide, Amiloride and Hypertonic Saline on Urinary Biomarkers in Healthy Subjects
Status: COMPLETED
Conditions: Nephropathy
Interventions: OTHER: hypertonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of BOS-580 in Obese Subjects at Risk for, or With Biopsy-confirmed, Nonalcoholic Steatohepatitis (NASH) With an Extension
Status: RECRUITING
Conditions: Nonalcoholic Steatohepatitis (NASH)
Interventions: DRUG: BOS-580|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intraoperative Infiltration With Bupivacain on the Development of Chronic Pain After Inguinal Hernia Repair
Status: COMPLETED
Conditions: Chronic Pain
Interventions: PROCEDURE: Infiltration with Saline|PROCEDURE: Infiltration with Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Singing in Groups for Parkinson's Disease; A Pilot Study of Group Singing Therapy for PD-related Voice/Speech Impairment
Status: COMPLETED
Conditions: Voice Quality and Voice Loudness Associated With Parkinson's Disease
Interventions: OTHER: Singing Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Will Restasis Eye Drops Increase Your Chance of Having a Successful Surgery?
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: Restasis|DRUG: Endura (artificial tears)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Postoperative Head Position as a Predictor of the Surgical Outcome After DMEK
Status: UNKNOWN
Conditions: Fuchs Endothelial Corneal Dystrophy|Pseudophakic Bullous Keratopathy|Chemical Burn of Cornea|Posterior Polymorphous Corneal Dystrophy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 3 Study to Evaluate the Immunogenicity and Safety of Inactivated Split Influenza Vaccine in Healthy Korea Children
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: IL-YANG FLU Vaccine Prefilled Syringe INJ.|BIOLOGICAL: VAXIGRIP Prefilled Syringe INJ.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of a Patient Decision Aid for Treatment of Aortic Stenosis
Status: COMPLETED
Conditions: Aortic Valve Stenosis
Interventions: BEHAVIORAL: "Treatment Choices for Aortic Stenosis" Decision Aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase II Study of TPA Plus Dexamethasone & CMT in Hematologic Malignancies
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: 12-O-tetradecanoylphorbol-13-acetate|DRUG: Dexamethasone|DRUG: Choline magnesium trisalicylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Versus Open Pancreatoduodenectomy Following Neoadjuvant Chemotherapy for BRPC
Status: RECRUITING
Conditions: Borderline Resectable Pancreatic Cancer
Interventions: PROCEDURE: Laparoscopic pancreatoduodenectomy|PROCEDURE: Open pancreatoduodenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placebo Controlled, Randomized Safety and Efficacy Study of RC-1291 in Cancer Anorexia/Cachexia
Status: COMPLETED
Conditions: Cancer Cachexia
Interventions: DRUG: RC-1291|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Inhalation SLIT Cisplatin (Liposomal) for the Treatment of Osteosarcoma Metastatic to the Lung
Status: COMPLETED
Conditions: Osteosarcoma Metastatic
Interventions: DRUG: Cisplatin liposomal
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Dose Study to Evaluate the Safety of Multiple Doses of Denosumab 120 mg in Adults With Severe Chronic Kidney Disease (CKD) and CKD on Dialysis
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Denosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-management in Chronic Obstructive Pulmonary Disease (COPD) Patients Compared to Usual Care
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: Self Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Investigate the Efficacy and Safety of Balovaptan (RO5285119) in Participants With Autism Spectrum Disorder (ASD)
Status: TERMINATED
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Placebo|DRUG: RO5285119
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lumbar Erector Spinae Plane Block vs Fascia Iliaca Block vs Lumbar Plexus Block for Postoperative Analgesia for Total Hip Arthroplasty
Status: RECRUITING
Conditions: Lumbar Erector Spinae Plane Block|Fascia Iliaca Block|Lumbar Plexus Block|Analgesia|Total Hip Arthroplasty
Interventions: OTHER: Lumbar Erector Spinae Plane Block|OTHER: Fascia Iliaca Block|OTHER: Lumbar Plexus Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MP-AzeFlu Allergen Chamber - Onset of Action Study
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Azelastine hydrochloride + fluticasone propionate nasal spray|DRUG: Placebos|DRUG: fluticasone propionate nasal spray + loratadine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Collection of Human Liver Biopsy and Whole Blood Samples From T1DM, TP or PP Patients for Potential Use for Insulin Producing Cells in Future Clinical Studies
Status: UNKNOWN
Conditions: Type 1 Diabetes|Pancreatectomy; Hyperglycemia
Interventions: OTHER: Liver biopsy collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Inulin on Gut Microbiota and Gut Barrier in Chronic Kidney Disease
Status: RECRUITING
Conditions: Chronic Kidney Disease 5D
Interventions: DIETARY_SUPPLEMENT: Inulin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Atezolizumab Versus Observation as Adjuvant Therapy in Participants With High-Risk Muscle-Invasive Urothelial Carcinoma (UC) After Surgical Resection
Status: TERMINATED
Conditions: Carcinoma, Transitional Cell
Interventions: DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wuling Powder for the Treatment and Underlying Mechanism of Depressive Symptoms in Patients With Parkinson's Disease
Status: UNKNOWN
Conditions: Antidepressive Agents
Interventions: DRUG: Wuling Powder|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Brain Stimulation to Improve Unsteady Gait in Older Adults (StimGait)
Status: NOT_YET_RECRUITING
Conditions: Fall|Gait, Unsteady|Mobility Limitation
Interventions: DEVICE: Transcranial direct current stimulation (tDCS) (active)|DEVICE: Transcranial direct current stimulation (tDCS) (Sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Surface Refractive Index Shift of Kalifilcon A Lenses Compared to Dailies Total 1, Precision 1 and Biotrue ONEday Lenses
Status: COMPLETED
Conditions: Habitual Soft Contact Lens Use
Interventions: DEVICE: kalifilcon A lenses|DEVICE: Dalies Total 1|DEVICE: Precision 1|DEVICE: Biotrue ONEday
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Application of Wearable Devices to Build a Self-Management Model in Chronic Kidney Disease Patients
Status: COMPLETED
Conditions: Chronic Kidney Disease Stage 1|Chronic Kidney Disease Stage 2|Chronic Kidney Disease stage3|Chronic Kidney Disease stage4
Interventions: BEHAVIORAL: Mobile health application and social media
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MUSCLE - Nordic Walking in MUltiple SCLErosis
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis, Chronic Progressive|Multiple Sclerosis|Multiple Sclerosis, Primary Progressive|Multiple Sclerosis, Secondary Progressive
Interventions: OTHER: Nordic Walking (NWG)|OTHER: Free Walking (FWG)|OTHER: Health Education (HEG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of SMS, IVR, and CATI Surveys in Colombia
Status: COMPLETED
Conditions: Surveys and Questionnaires|Noncommunicable Diseases
Interventions: OTHER: SMS Survey|OTHER: IVR Survey|OTHER: CATI Survey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinical Trial to Assess Safety and Efficacy of Autologous Cultured Epidermal Grafts Containing Epidermal Stem Cells Genetically Modified in Patients With JEB (HOLOGENE17)
Status: TERMINATED
Conditions: Junctional Epidermolysis Bullosa
Interventions: OTHER: Transplantation surgery of genetically corrected cultured epidermal autograft (ATMP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of PRO95780 in Patients With Previously Untreated, Advanced-Stage Non-Small Cell Lung Cancer (APM4074g)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: bevacizumab|DRUG: carboplatin|DRUG: paclitaxel|DRUG: placebo|DRUG: PRO95780
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT