pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Valopicitabine Alone and Together With Pegylated Interferon in Patients With Chronic Hepatitis C Who Have Failed to Respond to Standard Therapy
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: valopicitabine|DRUG: pegylated interferon|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Phase I/II Clinical Trial of PT-112 Injection for Advanced Solid Tumors and Advanced Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Advanced Solid Tumors
Interventions: DRUG: PT-112 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selinexor in Treating Patients With Abiraterone Acetate and/or Enzalutamide Refractory Metastatic Castration-Resistant Prostate Cancer
Status: TERMINATED
Conditions: Castration Levels of Testosterone|Hormone-Resistant Prostate Cancer|Metastatic Prostate Carcinoma in the Soft Tissue|Prostate Carcinoma Metastatic in the Bone|PSA Progression|Stage IV Prostate Adenocarcinoma AJCC v7
Interventions: DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thread Embedding Acupuncture Combined With Auricular Acupuncture for Overweight and Obesity
Status: COMPLETED
Conditions: Overweight or Obesity
Interventions: OTHER: Auricular acupuncture|OTHER: Thread embedding acupuncture|OTHER: Sham Thread embedding acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sacubitril-valsartan Versus Usual Anti-hypertensives in LVAD
Status: WITHDRAWN
Conditions: Congestive Heart Failure|Hypertension
Interventions: DRUG: Entresto|DRUG: Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-dose Study Evaluating Romosozumab (AMG 785) in Healthy Postmenopausal Japanese and Non-Japanese Women
Status: COMPLETED
Conditions: Osteopenia
Interventions: DRUG: Romosozumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate Safety and Efficacy of a Product Named VGN-R09b in Patients With Parkinson's Disease
Status: NOT_YET_RECRUITING
Conditions: Parkinson's Disease
Interventions: DRUG: VGN-R09b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the Association Drugs in Patients With Allergic Dermatitis
Status: WITHDRAWN
Conditions: Dermatitis
Interventions: DRUG: dexamethasone 0.5 mg and 1.0 mg clemastine cream|DRUG: Dexamethasone 0,5 mg cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clomiphene Citrate in Infertile Men With Idiopathic Oligoasthenozoospermia
Status: COMPLETED
Conditions: Infertility, Male
Interventions: DRUG: Clomiphene Citrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: TOFAcitinib Plus Hydroxycloroquine vs Hydroxycloroquine in Patients With COVID-19 Interstitial Pneumonia
Status: UNKNOWN
Conditions: Pneumonitis, Interstitial|COVID-19
Interventions: DRUG: Tofacitinib|DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Jaktinib in Adults With Alopecia Areata
Status: ACTIVE_NOT_RECRUITING
Conditions: Alopecia Areata
Interventions: DRUG: Jaktinib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Temozolomide Plus PEG-Interferon Alfa-2B in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: PEG-interferon alfa-2b|DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of The Safety Profile of First-line Avastin (Bevacizumab) in Combination With Paclitaxel in Patients With Locally Recurrent or Metastatic Her2-negative Breast Cancer (AVATAX)
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: bevacizumab [Avastin]|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Pain and Antibacterial Activity of Chitosan Versus Sodium Hypochlorite as Irrigant in Infected Canal
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: chitosan nanoparticles|DRUG: Sodium Hypochlorite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Observational Study to Evaluate the Safety and Efficacy of Polyclonal Antibodies in Simultaneous Pancreas Kidney Transplant Recipients
Status: UNKNOWN
Conditions: CKD (Chronic Kidney Disease) Stage 5T|Diabetes Mellitus|Simultaneous Pancreas Kidney Transplantation
Interventions: DRUG: Anti-Tlymphocyte Globulins|DRUG: Anti-Thymocyte Globulins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Tracheal Intubation Using Videolaryngoscope vs Fiberoptic Bronchoscope in Patients With Cervical Immobilization
Status: COMPLETED
Conditions: Intubation, Intratracheal
Interventions: PROCEDURE: intubation with videolaryngoscope vs fiberoptic bronchoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of ALG-097558 in Subjects With Hepatic Impairment and in Healthy Subjects With Normal Hepatic Function
Status: NOT_YET_RECRUITING
Conditions: COVID-19
Interventions: DRUG: ALG-097558
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Describe Patterns of Care and Outcomes of Men Who Are at High Risk After Experiencing Biochemical Failure Following Definitive Prostate Cancer Therapy, Men With Castration-resistant Prostate Cancer and Men With Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer|Castration-resistant Prostate Cancer|Metastatic Prostate Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Glucose Metabolism in Different PCOS Phenotypes
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Glucose Intolerance|Liver Fat|Glucose Metabolism Disorders
Interventions: DIAGNOSTIC_TEST: Oral glucose tolerance test (OGTT)|OTHER: 1H-magnetic resonance spectroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy Study of TVGV-1 Vaccine to Treat HPV Induced Cervical HSIL
Status: UNKNOWN
Conditions: Human Papillomavirus|High-Grade Squamous Intraepithelial Lesions
Interventions: BIOLOGICAL: TVGV-1|BIOLOGICAL: GPI-0100|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of EUS in Preventing Rebleeding After Endoscopic Cyanoacrylate Injection for Gastric Varices
Status: UNKNOWN
Conditions: Liver Cirrhosis|Gastric Varix|Portal Hypertension
Interventions: PROCEDURE: Endoscopic ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Erector Spina Plane Block and Thoracic Epidural Block
Status: COMPLETED
Conditions: Breast Neoplasms|Pain, Postoperative
Interventions: OTHER: Erector spina plane block before general anaesthesia|OTHER: Thoracic epidural block before general anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "neoBREASTIM": Atezolizumab Plus RP1 Oncolytic Immunotherapy in the NeoAdjuvant Setting of Triple-Negative Breast Cancer
Status: RECRUITING
Conditions: Triple Negative Breast Neoplasms
Interventions: COMBINATION_PRODUCT: Atezolizumab + RP1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Acute Effect of a Theacrine-based Supplement on Mobilization of Various Stem Cell Populations.
Status: COMPLETED
Conditions: Stem Cells
Interventions: DIETARY_SUPPLEMENT: NAD3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparing Effectiveness of CSE Versus DPE for Labor Analgesia
Status: COMPLETED
Conditions: Labor Pain
Interventions: DRUG: Ropivacaine 0.1% Injectable Solution|DRUG: Bupivacaine 0.25% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Computer Controlled Intraosseous Anesthesia in Pediatric Dental Patients
Status: RECRUITING
Conditions: Irreversible Pulpitis|Tooth Extraction
Interventions: DEVICE: Quicksleeper5|DEVICE: conventional anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: IF-MCT 16:8: Investigating the Influence of Intermittent Fasting With and Without MCTs in Patients With Drug-resistant Epilepsy
Status: RECRUITING
Conditions: Epilepsy|Intermittent Fasting
Interventions: OTHER: IF 16:8 as active comparator vs. IF MCT 16:8 as experimental arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sustained Effect of Red-light Therapy for Myopia Control: A 2-Year Post-Trial Follow-up Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Myopia
Interventions: DEVICE: Red-light therapy device|DEVICE: Spectacles
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Effort Against Secondhand Smoke (CEASE) Program or Standard Care in Helping Parents Stop Smoking
Status: COMPLETED
Conditions: Tobacco Use Disorder
Interventions: BEHAVIORAL: smoking cessation intervention|OTHER: cancer prevention|OTHER: counseling intervention|OTHER: educational intervention|OTHER: laboratory biomarker analysis|OTHER: questionnaire administration|OTHER: survey administration|PROCEDURE: study of high risk factors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Dexmedetomidine vs Propofol TIVA (Total Intravenous Anesthesia) and Interscalene Block
Status: COMPLETED
Conditions: Shoulder Pain
Interventions: DRUG: Dexmedetomidine|DRUG: Propofol|OTHER: Interscalene block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: A Trial of Efficacy and Safety of Remimazolam Tosilate for Injection in Local Anesthesia Assisted Sedation
Status: COMPLETED
Conditions: Local Anesthesia Assisted Sedation
Interventions: DRUG: Remimazolam Tosilate|DRUG: Propofol Injection.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of LNP023 in Patients With Kidney Disease Caused by Inflammation
Status: COMPLETED
Conditions: IgA Nephropathy
Interventions: DRUG: LNP023|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Hydroxychloroquine Alone or Associated for Inpatients With SARS-CoV2 Virus (COVID-19)
Status: WITHDRAWN
Conditions: Coronavirus Infections|SARS-CoV 2|SARS (Severe Acute Respiratory Syndrome)|Pulmonary Disease
Interventions: DRUG: Hydroxychloroquine Sulfate|DRUG: Hydroxychloroquine Sulfate + Azythromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined HAIC, Lenvatinib and Cadonilimab as Conversion Therapy for Unresectable Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma Non-resectable
Interventions: PROCEDURE: HAIC|DRUG: Lenvatinib plus cadonilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reaching 90 90 90 in Adolescents in Zambia: Using All Our SKILLZ
Status: COMPLETED
Conditions: HIV Infections|Pregnancy Related|STI|Mental Health Wellness 1
Interventions: BEHAVIORAL: SKILLZ-Girl curriculum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of Voxilaprevir Plus Sofosbuvir/Velpatasvir Fixed Dose Combination in Adults With Chronic Non-Genotype 1 HCV Infection
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: VOX|DRUG: SOF/VEL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Oral Gel for Prevention of Radiation Induced Oral Mucositis
Status: UNKNOWN
Conditions: Oral Mucositis Due to Radiation
Interventions: DRUG: vitamin D oral gel|DRUG: Miconazole Topical Gel|DRUG: BBC oral spray|DRUG: Oracure gel|OTHER: Alkamisr sachets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: APART Advanced Profiling of Anti-Rheumatic Therapies
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: PROCEDURE: Use of an Electronic Data Capture System by patients and physicians to assess patient-physician interactions & therapeutic decisions & outcomes in RA subjects.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial
Status: COMPLETED
Conditions: Necrotizing Soft Tissue Infection|Necrotizing Fasciitis|Gas Gangrene|Fournier Gangrene
Interventions: DRUG: IVIG (Privigen)|DRUG: Saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy in MSI/dMMR Tumors in Perioperative Setting.
Status: ACTIVE_NOT_RECRUITING
Conditions: Localized Resectable Tumor|MSI/dMMR
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Tolerability and Pharmacokinetics of CKD-348(5)
Status: COMPLETED
Conditions: Hypertension and Dyslipidemia
Interventions: DRUG: CKD-348(5)|DRUG: CKD-828, D097, D337
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Telerehabilitation in Patients With Subacromial Pain Syndrome
Status: WITHDRAWN
Conditions: Subacromial Pain Syndrome
Interventions: OTHER: Telerehabilitation|OTHER: Standard Physiotherapy|OTHER: Home Exercise Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of a Brain Preservation Diet in Preventing Cognitive Decline in Old Age Hostel Residents
Status: COMPLETED
Conditions: Cognitive Decline|Dietetic Intake
Interventions: OTHER: "brain preservation' diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Enriched-CRT 2017: Advanced Gastric Cancer With LN+ and LVI+, Chemotherapy vs. Chemoradiotherapy
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: RADIATION: chemoradiotherapy|DRUG: chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adductor Canal Block With Posterior Capsular Injection for Total Knee Replacement
Status: COMPLETED
Conditions: Pain|Osteoarthritis
Interventions: PROCEDURE: Canal Block and Capsular Injection|PROCEDURE: Femoral with Tibial Nerve Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Short-course Trastuzumab, Pertuzumab With Taxanes in the Adjuvant Treatment of Early HER2-positive Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Pertuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: POTENT - Tepotinib in Combination With Pembrolizumab in NSCLC
Status: RECRUITING
Conditions: Advanced Cancer|Non Small Cell Lung Cancer
Interventions: DRUG: Tepotinib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pedometer-based Behavioural Intervention for Individuals With COPD to Stay Active After Rehabilitation
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: BEHAVIORAL: Pedometer-based activity promotion|BEHAVIORAL: Short patient education and exercise|OTHER: Pulmonary rehabilitation (Standard care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lesion Characteristics After Pulsed-Field Ablation in Patients With Atrial Fibrillation and a Left Common Ostium
Status: COMPLETED
Conditions: Atrial Fibrillation|Pulmonary Vein Isolation|Ablation Therapy
Interventions: OTHER: Creating an electro-anatomical map
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TAE and Surgery in Patients With Peptic Ulcer Bleeding Uncontrolled by Endoscopic Therapy
Status: TERMINATED
Conditions: Peptic Ulcer|Bleeding
Interventions: PROCEDURE: Trans-catheter arterial embolization|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Large Tidal Volumes Despite Minimal Inspiratory Support in Spontaneously Ventilated Intubated Resuscitation Patients. Pathophysiological Exploratory Study.
Status: UNKNOWN
Conditions: Invasive Mechanical Ventilation|Ventilator-Induced Lung Injury|Patient-Self Inflicted Lung Injury|Encephalopathy|Intensive Care Unit|Tidal Volume
Interventions: OTHER: Multiparametric mesurements
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Establishment of Cessation Therapy by Clinical Trials for Subjects With Betel-quid Dependence and Oral Pre-cancer
Status: TERMINATED
Conditions: Addiction
Interventions: DRUG: escitalopram|DRUG: Moclobemide|DRUG: Placebo - Cap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Metformin Hydrochloride Extended-Release Tablets USP 750 mg Under Fasting Condition
Status: COMPLETED
Conditions: Fasting
Interventions: DRUG: Metformin Hydrochloride Extended-Release Tablets USP 750 mg|DRUG: GLUCOPHAGE®XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Two Year Study of the Clinical Efficacy of the Combination of Emtricitabine, Tenofovir, and Nevirapine
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Nevirapine, FTC, and Tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Antidepressant Treatment for Depression in People With Parkinson's Disease
Status: COMPLETED
Conditions: Depressive Disorder|Parkinson Disease
Interventions: DRUG: Atomoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Intravenous Infusion Study of rHIgM22 in Patients With Multiple Sclerosis Immediately Following a Relapse
Status: COMPLETED
Conditions: Multiple Sclerosis, Acute Relapsing
Interventions: DRUG: rHIgM22|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Effectiveness of PEMF as a Treatment Adjunct to Eccentric Exercise for Achilles Tendinopathy
Status: ENROLLING_BY_INVITATION
Conditions: Achilles Tendinopathy
Interventions: DEVICE: Active PEMF|DEVICE: Sham PEMF|OTHER: Eccentric exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Safety and Efficacy of a Leishmania Vaccine to Prevent Post Kala Azar Dermal Leishmaniasis (PKDL)
Status: WITHDRAWN
Conditions: Post-kala-azar Dermal Leishmaniasis
Interventions: BIOLOGICAL: Vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Proportional Open Ventilation (POV) Device and Its Efficacy in Managing Acute Respiratory Failure in COVID-19 Patients
Status: UNKNOWN
Conditions: Acute Respiratory Failure|Covid19
Interventions: DEVICE: Life2000® Ventilator
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects Of Fx-1006A On Transthyretin Stabilization And Clinical Outcome Measures In Patients With V122I Or Wild-Type TTR Amyloid Cardiomyopathy
Status: COMPLETED
Conditions: Cardiomyopathy
Interventions: DRUG: Fx-1006A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane vs. Paravertebral Nerve Block for Thoracic Surgery
Status: COMPLETED
Conditions: Thoracic Surgical Procedures
Interventions: DRUG: Paravertebral nerve block|DRUG: Erector Spinae nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Operative Pain and Opioid Reduction Trial After Bunionectomy
Status: COMPLETED
Conditions: Hallux Valgus and Bunion
Interventions: DRUG: Analgesic Non Narcotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Bioavailability - Gender Effect - Single and Multiple Ascending Dose Safety and Pharmacokinetic Study of GFT505
Status: COMPLETED
Conditions: Type 2 Diabetes|Diabetes Mellitus, Type 2|Metabolic Diseases|Cardiovascular Diseases|Obese|Dyslipidemia
Interventions: DRUG: GFT505 120mg - old formulation|DRUG: GFT505 120mg - new formulation|DRUG: GFT505 180mg - new formulation|DRUG: GFT505 240mg - new formulation|DRUG: GFT505 300mg - new formulation|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Nicotine Lozenge in Relief of Provoked Acute Craving
Status: COMPLETED
Conditions: Smoking|Smoking Cessation
Interventions: DRUG: Nicotine lower dose|DRUG: Nicotine higher dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Yan Nian Jiu Zhuan Fa Improve Chronic Fatigue Syndromes
Status: UNKNOWN
Conditions: Chronic Fatigue Syndromes
Interventions: BEHAVIORAL: Yan Nian Jiu Zhuan Fa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing Hypertension and Sympathetic Overactivation by Targeting Phosphate
Status: COMPLETED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: High Phosphate Phase|DIETARY_SUPPLEMENT: Low Phosphate Phase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: New Techniques for Diagnosis and Treatment of Cognitive Impairment in Affective Disorder
Status: RECRUITING
Conditions: Affective Disorder
Interventions: DEVICE: Transcranial magnetic stimulation|DEVICE: Transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study on Higher-dose Oseltamivir Treatment's Impact on Viral Clearance and Clinical Recovery in Adults Hospitalized With Influenza
Status: COMPLETED
Conditions: Influenza|Respiratory Tract Infections
Interventions: DRUG: Oseltamivir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Aspirin on Mammogram Density in Healthy Postmenopausal Women With a Moderate or High Level of Breast Density
Status: COMPLETED
Conditions: Mammographic Breast Density
Interventions: DRUG: Aspirin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Fat Grafts With Adipose-derived Regenerative Cells for Soft Tissue Reconstruction in Children
Status: COMPLETED
Conditions: Craniofacial Microsomia
Interventions: PROCEDURE: Fat grafts supplemented with ADRC|PROCEDURE: Structural fat grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Monitoring Asthma and COPD in Primary Care
Status: COMPLETED
Conditions: Lung Diseases, Obstructive|Asthma
Interventions: DEVICE: half-yearly monitoring routine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluate the Utility of 18FDG-PET as a Tool to Quantify Atherosclerotic Plaque (MK-0000-081 AM3)(COMPLETED)
Status: COMPLETED
Conditions: Atherosclerotic Vascular Disease
Interventions: DRUG: atorvastatin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Axalimogene Filolisbac (ADXS11-001) High Dose in Women With Human Papillomavirus (HPV) + Cervical Cancer
Status: COMPLETED
Conditions: Effects of Immunotherapy|Metastatic/Recurrent Cervical Cancer|Cervical Adenocarcinoma|Cervical Adenosquamous Cell Carcinoma|Cervical Squamous Cell Carcinoma|Cervical Small Cell Carcinoma|Stage III Cervical Cancer|Stage IVA Cervical Cancer|Stage IVB Cervical Cancer
Interventions: BIOLOGICAL: Axalimogene filolisbac
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Quality of Life, Perceived Stress and Coping Ways of Caregivers of Mentally Handicapped Individuals
Status: COMPLETED
Conditions: Intellectual Disability
Interventions: OTHER: Pre-post test|BEHAVIORAL: face-to-face training + PMR exercise|BEHAVIORAL: mobile health education + PMR exercise|BEHAVIORAL: face-to-face and mobile health education + PMR exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acamprosate vs. Placebo in Bipolar Alcoholics
Status: COMPLETED
Conditions: Alcohol Dependence|Bipolar Disorder
Interventions: DRUG: Acamprosate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adrenal Suppression and Absorption Study of Halobetasol Propionate Foam in Subjects 12-17 With Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Halobetasol Topical Foam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Total Body Irradiation and Fludarabine Followed By Allogeneic Peripheral Blood Stem Cell or Bone Marrow Transplantation in Combination With Cyclosporine and Mycophenolate Mofetil in Patients With Inherited Disorders
Status: COMPLETED
Conditions: Metabolism, Inborn Errors|Granulomatous Disease, Chronic
Interventions: DRUG: cyclosporine|DRUG: fludarabine|DRUG: mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: APOL1 Genetic Testing in African Americans
Status: RECRUITING
Conditions: Genetic Predisposition|Chronic Kidney Diseases|Nephropathy
Interventions: GENETIC: Assessment of the frequency of APOL-1 renal risk variant in the black population, and evaluating their attitudes about genetic testing and APOL1 genotype via self-administered surveys
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PK PD of the Enantiomers of Tramadol and O-desmethyltramadol in Elderly and Young Subjects
Status: COMPLETED
Conditions: Aging|Pain
Interventions: DRUG: Tramadol extended release 200 mg|BEHAVIORAL: CP/T|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Perioperative Hypotension in Gynaecologic Oncologic Surgery: HPI-ClearSight Versus Arterial Waveform Analysis
Status: COMPLETED
Conditions: Hypotension|Hemodynamic Instability|Gynecologic Cancer
Interventions: DEVICE: Hypotension Prediction Index
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Understanding and Appraising the New Medicine Service in England
Status: COMPLETED
Conditions: Asthma|Pulmonary Disease, Chronic Obstructive|Diabetes Mellitus, Type 2|Hypertension|Blood Coagulation
Interventions: OTHER: New Medicine Service
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Prospective Study to Assess the Screening Value of N-terminal Pro-B-type Natriuretic Peptide (NT-proBNP) for the Identification of Patients That Benefit From Additional Cardiac Testing Prior to Vascular Surgery
Status: UNKNOWN
Conditions: Peripheral Vascular Disease
Interventions: DEVICE: Elecsys®proBNP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of FCX-007 for Recessive Dystrophic Epidermolysis Bullosa
Status: ACTIVE_NOT_RECRUITING
Conditions: Recessive Dystrophic Epidermolysis Bullosa
Interventions: BIOLOGICAL: FCX-007 (dabocemagene autoficel; see below for FCX-007 description)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study of Papacarie® and the Conventional Method for Dental Caries Treatment
Status: COMPLETED
Conditions: Dental Caries|Secondary Dental Caries|Personal Satisfaction
Interventions: DEVICE: Papacarie®|PROCEDURE: Conventional method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Folic Acid Supplementation to Reduce Anemia in Extremely Preterm Infants
Status: NOT_YET_RECRUITING
Conditions: Extreme Prematurity|Anemia of Prematurity
Interventions: DIETARY_SUPPLEMENT: Folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: SAINT:Trabectedin, Ipilimumab and Nivolumab as First Line Treatment for Advanced Soft Tissue Sarcoma
Status: RECRUITING
Conditions: Advanced Soft Tissue Sarcoma|Metastatic Soft Tissue Sarcoma
Interventions: DRUG: Trabectedin|DRUG: Ipilimumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Couple's Retreats for Posttraumatic Stress Disorder
Status: TERMINATED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Accelerated, Intensive, Multi-Couple Cognitive Behavioral Couples Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Femoral Vein Hemostasis After Ablation for Atrial Fibrillation With Manual Pressure Versus a Figure of 8 Suture
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Ablation for atrial fibrillation.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prospective Randomized Controlled Treatment Trial for Chronic Central Serous Chorioretinopathy
Status: COMPLETED
Conditions: Chronic Central Serous Chorioretinopathy
Interventions: PROCEDURE: Half-dose photodynamic therapy (PDT)|PROCEDURE: Micropulse laser (ML) treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Study of Two Rituximab Regimens in the Remission of ANCA Associated Vasculitis
Status: COMPLETED
Conditions: Granulomatosis With Polyangiitis|Microscopic Polyangiitis|Renal Limited Forms
Interventions: DRUG: Rituximab (Arm B)|DRUG: Rituximab (Arm A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Vitamin D3 Supplementation on Iron Status in Iron Deficient Women
Status: COMPLETED
Conditions: Iron Deficiency|Anemia; Deficiency, Nutritional, With Poor Iron Absorption|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D3 supplement|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Physical-Cognitive Training With Different Task Models in Parkinson's Disease With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Parkinson Disease
Interventions: BEHAVIORAL: Integrated physical-cognitive training|BEHAVIORAL: Consecutive physical-cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-inflammatory Effects of Tiotropium in Patients With Stable COPD
Status: UNKNOWN
Conditions: COPD
Interventions: DRUG: Tiotropium Bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating How CagriSema, Semaglutide and Cagrilintide Regulate Insulin Effects in the Body of People With Type 2 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide|DRUG: Cagrilintide|DRUG: Placebo semaglutide|DRUG: Placebo cagrilintide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Scalpel Versus Diathermy for Transverse Abdominal Incision in First Elective Caesarean Section
Status: NOT_YET_RECRUITING
Conditions: Cesarean Section|Intraoperative Blood Loss|Postoperative Pain|Wound Heal
Interventions: PROCEDURE: Skin incision with scalpel.|PROCEDURE: Skin incision with a diathermy.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness and Safety of Whitfield's Solution, Zinc Oxide Nanoparticles Solution or Combination for the Treatment of Fungal Feet Infection
Status: COMPLETED
Conditions: Fungal Foot Infection
Interventions: DRUG: Whitfield solution|DRUG: Zinc oxide nanoparticles solution|DRUG: Combined Whitfield and Zinc oxide nanoparticles solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Effect of Sirolimus on Non-Melanoma Skin Cancer in Kidney Transplant Recipients
Status: COMPLETED
Conditions: Skin Neoplasms|Kidney Transplantation
Interventions: DRUG: sirolimus|DRUG: cyclosporine or tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Gastric Varices Treatment: Coil + Cyanoacrylate Versus Cyanoacrylate
Status: UNKNOWN
Conditions: Gastric Varices
Interventions: DEVICE: Treatment: coil + cyanoacrylate|DEVICE: Treatment: cyanoacrylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determine the Pharmacokinetics and Safety of Brivanib in Chinese Subjects With Advanced Primary Liver Cancer (Hepatocellular Carcinoma: HCC)
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Brivanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Chronic Myelogenous Leukemia
Status: WITHDRAWN
Conditions: Leukemia
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: recombinant interferon gamma|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: cyclosporine|DRUG: cytarabine|DRUG: idarubicin|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of TAK-733 in Combination With Alisertib in Adult Patients With Advanced Nonhematologic Malignancies
Status: WITHDRAWN
Conditions: Advanced Nonhematologic Malignancies
Interventions: DRUG: TAK-733 and alisertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of SCH 527123 in Subjects With Severe Asthma (Study P05109AM1)
Status: WITHDRAWN
Conditions: Asthma
Interventions: DRUG: SCH 527123|DRUG: SCH 527123|DRUG: SCH 527123|DRUG: SCH 527123
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Proof of Concept Study of Pradigastat in Patients With Functional Constipation
Status: COMPLETED
Conditions: Functional Constipation
Interventions: DRUG: Pradigastat Tablets 20mg|DRUG: Pradigastat Tablets 40mg|DRUG: Pradigastat Tablets 20mg matching Placebo|DRUG: Pradigastat Tablets 40mg matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Non-Invasive Positive Pressure Ventilation in Patients With Severe Obesity Undergoing Upper Endoscopy Procedures
Status: COMPLETED
Conditions: Severe Obesity|Hypoxia
Interventions: DEVICE: Non-invasive positive pressure ventilation through nasal mask|DEVICE: Rescue non-invasive positive pressure ventilation through nasal mask|OTHER: Secondary rescue maneuvers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: EleVation carE: a Randomized Controlled Trial on the Prevention of Acute Mountain Sickness With Suxiao Jiuxin Pill
Status: NOT_YET_RECRUITING
Conditions: Acute Mountain Sickness
Interventions: DRUG: Suxiao Jiuxin Pill|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Understanding How Opioids Affect the Experiential and Neural Signatures of Social Experiences
Status: RECRUITING
Conditions: Naltrexone|Placebo
Interventions: DRUG: Naltrexone Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: n-3 Fatty Acids in Enteral Formula on NK Cell Activity
Status: COMPLETED
Conditions: Enteral Nutrition
Interventions: DIETARY_SUPPLEMENT: vegetable (canola, flaxseed) derived n-3 fatty acid|DIETARY_SUPPLEMENT: soybean oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bupropion & Cardio Birth Defect (Slone)
Status: COMPLETED
Conditions: Depressive Disorder
Interventions: DRUG: Exposure to any bupropion during the first trimester|DRUG: Exposure to bupropion alone during the first trimester|OTHER: Referent group: no exposure to any anti-depressant or anti-smoking drug during pregnancy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vascepa to Accelerate Lipoprotein Uptake and Elimination
Status: COMPLETED
Conditions: Lipid Disorder|Triglycerides High|Dyslipidemias
Interventions: DRUG: Icosapent Ethyl 1000 MG [Vascepa]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of SPARC0912 and Reference0912 in Open Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: SPARC0912|DRUG: Reference0912
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ketamine for Relapse Prevention in Recurrent Depressive Disorder
Status: TERMINATED
Conditions: Depression|Relapse|Recurrent Depressive Disorder|Major Depressive Disorder
Interventions: DRUG: Ketamine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Rapid Intravenous Infusion of Velaglucerase Alfa (VPRIV) in Treatment-naive Patients With Type 1 Gaucher Disease
Status: COMPLETED
Conditions: Primary Disease
Interventions: DRUG: VPRIV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Monitoring of Diabetes in Young Children With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: BEHAVIORAL: Developmental Demands|BEHAVIORAL: Distress Reduction|BEHAVIORAL: Remote Monitoring|BEHAVIORAL: Fear of Hypoglycemia|BEHAVIORAL: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telavancin Blood and Cerebrospinal Fluid Concentrations in Patients With Subarachnoid Hemorrhage
Status: RECRUITING
Conditions: Subarachnoid Hemorrhage, Aneurysmal
Interventions: DRUG: Telavancin Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Platelet-rich Plasma on the Rate and Type of Orthodontic Tooth Movement
Status: COMPLETED
Conditions: Class II Division 1 Malocclusion
Interventions: BIOLOGICAL: PRP injection|PROCEDURE: En-masse retraction of upper anterior teeth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ZP120 Add-on to Furosemide in Treatment of Acute or Sub-Acute Decompensated Heart Failure
Status: TERMINATED
Conditions: Heart Failure, Congestive
Interventions: DRUG: ZP120|PROCEDURE: I.v. catherization|PROCEDURE: 6-minutes walk performance|BEHAVIORAL: Dyspnea severity assessment|PROCEDURE: Blood sampling for laboratory tests|PROCEDURE: ECG|PROCEDURE: Physical examination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Whether 3 New Oral Formulations of a Strong Pain Killer Release the Same Amount of Drug Into the Body as the Marketed Medication
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: MRXXX|DRUG: MR1XXX|DRUG: MR2XXX|DRUG: MR3XXX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER