pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Physical Activity Following Thoracic Mobilization on Heart Rate Variability and Pressure Pain Threshold.
Status: COMPLETED
Conditions: Healthy
Interventions: PROCEDURE: Physical activity plus thoracic mobilization|PROCEDURE: Physical activity|PROCEDURE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy, Pharmacokinetics, Pharmacodynamics of ACZ885 in Patients With NALP3 Mutations and Clinical Symptoms
Status: COMPLETED
Conditions: NALP3 Mutation
Interventions: DRUG: canakinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lopinavir/Ritonavir (Kaletra) PK in Children
Status: COMPLETED
Conditions: HIV/AIDS Treatment|HIV Infections
Interventions: DRUG: lopinavir/ritonavir (Kaletra®) tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Darunavir/Ritonavir + Lamivudine Versus Darunavir/Ritonavir +Emtricitabine/Tenofovir in Naïve HIV-1 Infected Subjects
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: darunavir/ritonavir|DRUG: Lamivudine|DRUG: emtricitabine-tenofovir(FTC/TDF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antineoplaston Therapy in Treating Patients With Advanced Mesothelioma
Status: TERMINATED
Conditions: Malignant Mesothelioma
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Standard High-Dose Alpha Interferon Versus Intermittent High-Dose Alpha Interferon
Status: UNKNOWN
Conditions: Adjuvant|Stage III Malignant Melanoma|Interferon Alpha|Therapy
Interventions: DRUG: Interferon-alpha-2b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Dexlansoprazole MR on Heartburn Control in Participants Previously Receiving Twice Daily Proton Pump Inhibitor Therapy
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DRUG: Dexlansoprazole MR QD
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase1 First in Human Ascending Dose Study to Evaluate the Safety and Tolerability of FC-12738 in Health Adults
Status: RECRUITING
Conditions: Safety Issues|Tolerance
Interventions: DRUG: FC-12738|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PharmacoKINEtics of TAMoxifen and Its Metabolites in Breast Cancer Patients: the Influence of a Dose Increase in Phenotypic Poor Metabolizers of CYP2D6 (KINETAM)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Tamoxifen 40mg QD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of 10 mg Amlodipine Besylate/ 20 mg Benazepril Hydrochloride Capsules of Dr.Reddys Laboratories Limited Under Non-fasting (Fed) Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Amlodipine Besylate / Benazepril Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)
Status: RECRUITING
Conditions: Primary Sclerosing Cholangitis
Interventions: DRUG: Volixibat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Explore the Short- and Mid-term Effects of Fespixon in Scar Cosmesis Following Cervical or Abdominal Surgery
Status: COMPLETED
Conditions: Scar
Interventions: DRUG: Fespixon cream|DRUG: Placebo Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Bongros-BMP Compared to Bio-oss for Regeneration of Alveolar Bone Tissue After Maxillary Sinus Floor Augmentation
Status: COMPLETED
Conditions: Regeneration of Alveolar Tissue After Maxillary Sinus Floor Augmentation
Interventions: DRUG: Novosis(bongros/BMP-2)|DRUG: Bio-oss
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: A Radiolabeled Mass Balance Study of [14C]-Ertugliflozin (PF04971729, MK-8835) In Healthy Male Participants (MK-8835-038)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus (T2DM)
Interventions: DRUG: Ertugliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Intrabony Defects With L-PRF Membrane With or Without Collagen Membranes
Status: COMPLETED
Conditions: Periodontal Bone Loss|Periodontal Diseases
Interventions: PROCEDURE: L-PRF|PROCEDURE: OFD|PROCEDURE: CM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Metabolism and Elimination of Carbon-14 Labeled Eribulin Acetate (14C-Eribulin) in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: eribulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Analgesic Effect of Hydromorphone on Partial Pulmonary Resection Under Video-assisted Thoracoscopy
Status: COMPLETED
Conditions: Pain, Postoperative|Thoracic Surgery, Video-Assisted
Interventions: DRUG: Hydromorphone|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First-In-Human Clinical Study for Treatment of Severe Mitral Valve INsufficiency With Epygon™ TRanscatheter Mitral VAlve System
Status: RECRUITING
Conditions: Mitral Valve Regurgitation
Interventions: DEVICE: Epygon™ Transcatheter Mitral Valve System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow Failure
Status: RECRUITING
Conditions: Severe Aplastic Anemia|Single Lineage Cytopenias, T-LGL|Hypoplastic MDS
Interventions: DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PCOSMIC Trial - PolyCystic Ovary Syndrome, Metformin for Infertility With Clomiphene
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Metformin|DRUG: Placebo|DRUG: Metformin + Clomiphene|DRUG: Metformin|DRUG: Clomiphene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Interleukin-21 for Metastatic Malignant Melanoma and Metastatic Kidney Cancer
Status: COMPLETED
Conditions: Melanoma|Kidney Neoplasms|Metastases
Interventions: DRUG: Recombinant Human Interleukin-21
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Lacticaseibacillus Paracasei Strain Shirota on Clinical Manifestation of Functional Constipation in Mexican Adults
Status: NOT_YET_RECRUITING
Conditions: Constipation
Interventions: DIETARY_SUPPLEMENT: fermented milk, Yakult
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Naproxen in Preventing DNA Mismatch Repair Deficient Colorectal Cancer in Patients With Lynch Syndrome
Status: COMPLETED
Conditions: Lynch Syndrome
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Naproxen|OTHER: Placebo Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Single and Multiple Ascending Dose Study of AMG 133 in Participants With Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: BIOLOGICAL: maridebart cafraglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Testing A Couple-based Program for Alcohol Risk Reduction in the National Guard
Status: COMPLETED
Conditions: Alcohol; Harmful Use
Interventions: BEHAVIORAL: In-person sessions: ABCP_P|BEHAVIORAL: Video conference sessions: ABCP_T
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Kefir Consumption on Various Parameters in Adults Subjects
Status: NOT_YET_RECRUITING
Conditions: Oxidative Stress
Interventions: OTHER: Kefir|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of Long-acting Injectable Risperidone and Risperidone Tablets in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Feasibility and Safety of Iron Repletion With Feraheme in Iron Deficient Patients With Durable Ventricular Assist Device Support
Status: TERMINATED
Conditions: Anemia
Interventions: DRUG: Ferumoxytol injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lipiodol Prior to FET (LIFE)
Status: NOT_YET_RECRUITING
Conditions: IVF|Frozen Embryo Transfer|Hysterosalpingography
Interventions: PROCEDURE: Lipiodol® uterine treatment prior to IVF/ICSI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Prospective Multi Center Cohort Study for Primary Diagnosis of Clinically Significant Prostate Cancer With Combination of PSA/DRE and Multi Parametric Magnetic Resonance Imaging
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: PSA test|DEVICE: multiparametric prostate Magnetic Resonance Imaging (mpMRI)|PROCEDURE: targeted MRI/US fusion-guided biopsy|PROCEDURE: combined prostate biopsy (systematic biopsy plus targeted MRI/US fusion-guided biopsy)|PROCEDURE: MRI inbore biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Esthetic Outcome of Isolated Advancement Genioplasty With and Without Submental Liposuction in Treatment of Skeletal Chin Deficiency
Status: UNKNOWN
Conditions: Receding Chin
Interventions: PROCEDURE: Submental liposuction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanistic Study of ISIS ISIS-APOCIIIRX in Type 2 Diabetes
Status: TERMINATED
Conditions: Type 2 Diabetes
Interventions: DRUG: ISIS-APOCIIIRX|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Neurocognitive and Social Cognitive Remediation in Patients at Ultra-High Risk of Psychosis
Status: COMPLETED
Conditions: Patients at Ultra-high Risk of Psychosis
Interventions: BEHAVIORAL: Cognitive remediation|BEHAVIORAL: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sentinel Lymph Node Biopsy With Superparamagnetic Iron Oxide for Breast Cancer Patients After Neoadjuvant Treatment.
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DEVICE: Tc+blue dye|DEVICE: Tc+SPIO|DEVICE: SPIO alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Randomized, Open-Label, Parallel-Group, Multi-Center Study for the Evaluation of Efficacy and Safety of Edoxaban Monotherapy Versus Low Molecular Weight (LMW) Heparin/Warfarin in Subjects With Symptomatic Deep-Vein Thrombosis
Status: COMPLETED
Conditions: Deep Vein Thrombosis|Venous Thrombosis
Interventions: DRUG: edoxaban tosylate|DRUG: enoxaparin/unfractionated heparin|DRUG: warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Investigating the Bioequivalence of the Fixed Dose Combination of COREG CR to COREG CR and ZESTRIL.
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: COREG CR|DRUG: Lisinopril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Resveratrol and Carbossimetyl Beta Glucan in Treatment of Upper Airways Disease in Infancy
Status: COMPLETED
Conditions: Common Cold
Interventions: DRUG: Resveratrol and Carbossimetyl Beta Glucan|OTHER: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative and Post-operative Analgesic Effect of IV Acetaminophen for Sinus Surgery
Status: COMPLETED
Conditions: Chronic Sinusitis
Interventions: DRUG: IV Acetaminophen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cisplatin and Radiation Therapy With or Without Carboplatin and Paclitaxel in Patients With Locally Advanced Cervical Cancer
Status: COMPLETED
Conditions: Cervical Adenocarcinoma|Cervical Adenosquamous Carcinoma|Cervical Squamous Cell Carcinoma, Not Otherwise Specified|Stage IB Cervical Cancer AJCC v6 and v7|Stage IIA Cervical Cancer AJCC v7|Stage IIB Cervical Cancer AJCC v6 and v7|Stage IIIB Cervical Cancer AJCC v6 and v7|Stage IVA Cervical Cancer AJCC v6 and v7
Interventions: RADIATION: Brachytherapy|DRUG: Carboplatin|DRUG: Cisplatin|RADIATION: External Beam Radiation Therapy|DRUG: Paclitaxel|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy and Safety of Q8003 Versus Its Individual Components in Bunionectomy Patients
Status: COMPLETED
Conditions: Moderate to Severe Postoperative Pain
Interventions: DRUG: Q8003|DRUG: Morphine sulfate|DRUG: Oxycodone HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Intralymphatic Immunotherapy in Pollen Allergic Adolescents and Young Adults With Asthma
Status: COMPLETED
Conditions: Rhinitis|Asthma|Allergy
Interventions: DRUG: ALK Alutard birch or 5-grasses|DRUG: ALK diluent 0,3% human albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Smart Autonomous Neuro-Rehabilitation System
Status: COMPLETED
Conditions: Cognition Disorders|Cognitive Deficits
Interventions: BEHAVIORAL: Cognitive rehabilitation training with RGS in the clinic|BEHAVIORAL: Passive/conventional cognitive training at home.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Based Acoustic Radiation Force Impulse Imaging
Status: COMPLETED
Conditions: Liver Fibrosis|Liver Inflammation
Interventions: DEVICE: Ultrasound-Based Acoustic Radiation Force Impulse (ARFI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Remotely Non-invasive Brain Stimulation and Videogame to Alleviate Depression
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DEVICE: active tDCS|DEVICE: sham tDCS|BEHAVIORAL: cognitive and emotional control video game|BEHAVIORAL: sham video game
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality During Ultrasound Examination of Women With Endometriosis
Status: UNKNOWN
Conditions: Chronic Pain|Pelvic Pain|Endometriosis
Interventions: DEVICE: SootheVR: AppliedVR, Los Angeles, California a head-mounted displa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of COVID-19 SARS-CoV-2 Variability in ICU Hospitalized Patients With Severe Disease
Status: RECRUITING
Conditions: SARS-CoV2 Infection|COVID-19 Acute Respiratory Distress Syndrome|Mutation
Interventions: OTHER: Nasopharyngeal swab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial Comparing Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Advanced Prostate Cancer and Cardiovascular Disease
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Degarelix|DRUG: Leuprolide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Esketamine Combined With Dexmedetomidine for Sedation of Mechanically Ventilated Patients
Status: RECRUITING
Conditions: Dexmedetomidine|Ketamine|Analgesia|Intensive Care Units|Mechanical Ventilation
Interventions: DRUG: Esketamine combined with dexmedetomidine|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Environmental Localization Mapping and Guidance for Visual Prosthesis Users
Status: RECRUITING
Conditions: Retinitis Pigmentosa|Visual Impairment|Visual Prosthesis
Interventions: DEVICE: Navigation System for Users of a Visual Prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase II Clinical Study of T-DM1 and Pyrotinib Maleate in Patients With HER2-positive Metastatic Breast Cancer Who Had Progressed on TKI Therapy
Status: NOT_YET_RECRUITING
Conditions: HER2+ Advanced Breast Cancer Patients Progressing on TKI Therapy
Interventions: DRUG: Trastuzumab Emtansine for Injection|DRUG: Pyrotinib Maleate Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Current Standard Malaria Treatment Guidelines in the Republic of the Sudan
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: ASP|DRUG: SDPQ|DRUG: 14DPQ|DRUG: 14DPQ on Day 42
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy of the Prostate and the Pelvic Lymph Nodes After Neoadjuvant Antihormonal Treatment
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: RADIATION: Intensity-modulated radiotherapy of the pelvic lymph nodes using SIB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NeoOPTIMIZE: Early Switching of mFOLFIRINOX or Gemcitabine/Nab-Paclitaxel Before Surgery for the Treatment of Resectable, Borderline Resectable, or Locally-Advanced Unresectable Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Adenocarcinoma|Stage 0 Pancreatic Cancer AJCC v8|Stage I Pancreatic Cancer AJCC v8|Stage III Pancreatic Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8
Interventions: DRUG: Capecitabine|DRUG: Fluorouracil|DRUG: Irinotecan Hydrochloride|DRUG: Leucovorin Calcium|DRUG: Losartan Potassium|DRUG: Oxaliplatin|RADIATION: Radiation Therapy|PROCEDURE: Resection|PROCEDURE: Diagnostic Imaging|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OPtimal Timing of Thromboprophylaxis in Traumatic IntraCranial Haemorrhage - Pilot Study
Status: UNKNOWN
Conditions: Traumatic Intracranial Haemorrhage
Interventions: DRUG: Enoxaparin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Aza With or Without ATRA in Newly Diagnosed Unfit AML or Intermediate,High or Very High Risk MDS
Status: UNKNOWN
Conditions: AML|MDS|Old Age; Debility|Hematologic Cancer
Interventions: DRUG: Azacitidine|DRUG: all trans retinoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Pharmacokinetics (PK) of Salbutamol Administered Via Metered Dose Inhalers (MDI) Containing Propellants HFA-152A (Test) or HFA-134A (Reference) in Healthy Participants Aged 18 to 55 Inclusive
Status: NOT_YET_RECRUITING
Conditions: Asthma|Healthy Participants
Interventions: DRUG: Salbutamol HFA-152a|DRUG: Salbutamol HFA-134a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Laser Acupuncture on Constipation in Patients With Advanced Cancer
Status: UNKNOWN
Conditions: Constipation|Advanced Cancer
Interventions: PROCEDURE: Laser acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of Bowklean and Klean-Prep With Dulcolax for the Bowel Preparation Prior Colonoscopy
Status: COMPLETED
Conditions: Bowel Preparation Before Colonoscopy
Interventions: DRUG: Picosulfate sodium, magnesium oxide, citric acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Assessing The Long Term Safety And Tolerability Of [S,S]-Reboxetine In Patients With Post-Shingles Pain.
Status: TERMINATED
Conditions: Pain
Interventions: DRUG: [S,S]-Reboxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Response of United Kingdom (UK) Infants to a Reduced Primary Schedule With Meningococcal C and Pneumococcal Conjugate Vaccines
Status: COMPLETED
Conditions: Pneumococcal Infections|Meningococcal Infections
Interventions: BIOLOGICAL: menjugate|BIOLOGICAL: Men C conjugate vaccine|BIOLOGICAL: Men C conjugate|BIOLOGICAL: Men C Conjugate|BIOLOGICAL: Men C conjugate|BIOLOGICAL: Men C conjugate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects Of Instrument Assisted Soft Tissue Mobilization on Pain, Grip Strength and Functional Activity in Patients With Lateral Epicondylitis
Status: COMPLETED
Conditions: Lateral Epicondylitis|Tennis Elbow
Interventions: DEVICE: Instrument Assisted Soft Tissue Mobilization (IASTM)|OTHER: Conventional Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Music Therapy in Gynecological Oncology
Status: COMPLETED
Conditions: Music Therapy|General Anesthesia|Surgery|Pain|Gynecological Cancer|Pain, Postoperative
Interventions: DEVICE: Headphones (Disok, Alicante, España)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Memantine on Magnetic Resonance (MR) Spectroscopy in Subjects at Risk for Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: memantine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of a Natural Polyphenolic Extract From Pomegrnate (POMX) on the Development of Atherosclerosis in Diabetic Patients
Status: UNKNOWN
Conditions: Atherosclerosis
Interventions: DRUG: POMx
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of EnXtra® and EnXtra® + Caffeine on Mental Alertness and Fatigue in Healthy Individuals
Status: NOT_YET_RECRUITING
Conditions: Fatigue|Mental Alertness
Interventions: DIETARY_SUPPLEMENT: EnXtra® (300 mg) + Placebo (300 mg)|DIETARY_SUPPLEMENT: Caffeine (200 mg) + Placebo (300 mg)|DIETARY_SUPPLEMENT: EnXtra® (300 mg) + Caffeine (200 mg)|DIETARY_SUPPLEMENT: Placebo (MCC 300 mg) + Placebo (300 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Glucagon Like Peptide 1 Receptor (GLP1R) Expression and Beta-cell Mass in Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus|Diabetes Mellitus, Type 2
Interventions: DRUG: 111In-DTPA-exendin-4|DRUG: IRDye800CW-exendin-4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Guilt Focused Psychological Intervention
Status: TERMINATED
Conditions: Guilt|Depressive Symptoms|Anxious Symptoms|Stress, Physiological
Interventions: BEHAVIORAL: Guilt Focused Intervention|BEHAVIORAL: Cognitive behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Insulin Degludec With Insulin Glargine U100 for Adults With Type 1 Diabetes Crossing Multiple Time Zones.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Insulin Degludec|DRUG: Insulin Glargine|DEVICE: TRESIBA® FLEXTOUCH®|DEVICE: LANTUS® SOLOSTAR® INSULIN PEN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MIcroglial Colony Stimulating Factor-1 Receptor (CSF1R) in Alzheimer's Disease
Status: TERMINATED
Conditions: Alzheimer Disease|Mild Cognitive Impairment
Interventions: DRUG: JNJ-40346527|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effect Dietary Fructose on Fructose Kinetics in Type 2 Diabetes
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: OTHER: high vs low fructose in caucasian dutch or surinamese asian type 2 diabetes subjects
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study of KITE-222 in Participants With Relapsed/Refractory Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|BIOLOGICAL: KITE-222
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study for the Evaluation of Incidence of Systemic Mastocytosis in t(8;21) Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Systemic Mastocytosis With AHNMD|Acute Myeloid Leukemia With T(8;21)(Q22;Q22)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Enhancing the Response to Rehabilitation After Stroke Using Repetitive Transcranial Magnetic Stimulation (rTMS)
Status: TERMINATED
Conditions: Stroke
Interventions: PROCEDURE: Repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial:Treatments on Infundibular Ventricular Septal Defect
Status: COMPLETED
Conditions: Heart Septal Defects, Ventricular|Double Outlet Right Ventricle, Noncommitted VSD|Double Outlet Right Ventricle, Subaortic VSD|Double Outlet Right Ventricle, Subpulmonary VSD|Supracristal Ventricular Septal Defect
Interventions: DEVICE: TEE-guided perventricular device closure without CBP|PROCEDURE: Surgery repair with CBP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Catheter Ablation vs Anti-arrhythmic Drug Therapy for Atrial Fibrillation Trial
Status: COMPLETED
Conditions: Atrial Fibrillation|Arrhythmia
Interventions: DEVICE: Left atrial ablation|DRUG: Rate or Rhythm Control Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Study of PI-88 in Post-resection Hepatocellular Carcinoma
Status: TERMINATED
Conditions: Cancer|Liver Cancer|Primary Liver Cancer|Hepatocellular Carcinoma|Hepatoma
Interventions: DRUG: PI-88|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pulsed tVNS Protocol and Reinforcement Learning
Status: RECRUITING
Conditions: Vagus Nerve Stimulation in Reward Learning
Interventions: DEVICE: taVNS stimulation|DEVICE: sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Unified Protocol for Adolescents (UP-A) Change Processes
Status: COMPLETED
Conditions: Anxiety Disorders|Depression|Obsessive-Compulsive Disorder|Adolescent - Emotional Problem|Emotional Disorder
Interventions: BEHAVIORAL: Unified Protocol for Emotional Disorders in Adolescents (UP-A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treosulfan-Based Versus Clofarabine-Based Conditioning Before Donor Hematopoietic Stem Cell Transplant for the Treatment of Myelodysplastic Syndromes or Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: Clofarabine|DRUG: Fludarabine|PROCEDURE: Hematopoietic Cell Transplantation|RADIATION: Total-Body Irradiation|DRUG: Treosulfan|PROCEDURE: Echocardiography|PROCEDURE: Multigated Acquisition Scan|PROCEDURE: Lumbar Puncture|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrating Mind-Body Practices Into Primary Care Treatment
Status: NOT_YET_RECRUITING
Conditions: Chronic Pain|Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: CIH Stepped Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Rates of Antimicrobial Use in Febrile Patients With or Without the Use of C-reactive Protein Blood Test
Status: RECRUITING
Conditions: Acute Febrile Illness|Use of Antimicrobial Agents|C-reactive Protein Level
Interventions: DIAGNOSTIC_TEST: C-reactive Protein Rapid Diagnostic Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Cyclin D1 as a Prognostic Factor in Multiple Myeloma and Its Association With the Immunological Prognostic Factor PDL1 and Clinical and Biochemical Lab Tests
Status: NOT_YET_RECRUITING
Conditions: Multiple Myeloma
Interventions: PROCEDURE: Bone marow biopsy and aspiration|DIAGNOSTIC_TEST: biochemical and heamatological tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Exploring Massage Benefits for Arthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: OTHER: Massage 30 min 2x/wk x4 wks then 1x/wk x4 wks|OTHER: Massage 60 min 2x/wk for 4 wks then 1x/wk for 4 wks|OTHER: Massage 30 min sessions 1x/wk for 8 wks|OTHER: Massage 60 min session 1x/wk for 8 wks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EXPRE-SON-REA : Expressive Own Names in Neurophysiologic Assessment of Comatose Patients
Status: UNKNOWN
Conditions: Comatose|Neurophysiologic Abnormality
Interventions: OTHER: Evoked related potential - P3 paradigm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Therapeutic Antioxidant Supplementation
Status: NOT_YET_RECRUITING
Conditions: Superficial Siderosis
Interventions: DIETARY_SUPPLEMENT: Inosine|DIETARY_SUPPLEMENT: IP6
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: S0307A, Long-Term Bone Quality in Women With Breast Cancer Enrolled on Clinical Trial SWOG-S0307
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: clodronate disodium|DRUG: demeclocycline hydrochloride|DRUG: ibandronate sodium|DRUG: tetracycline hydrochloride|DRUG: zoledronic acid|OTHER: laboratory biomarker analysis|PROCEDURE: adjuvant therapy|PROCEDURE: computed tomography|PROCEDURE: dual x-ray absorptiometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of γδ T Cell Against Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: BIOLOGICAL: CIK|BIOLOGICAL: γδ T|BIOLOGICAL: CIK and γδ T
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Ultrasound in Assessing Post-prostatectomy Erectile Dysfunction
Status: RECRUITING
Conditions: Prostate Adenocarcinoma
Interventions: DIAGNOSTIC_TEST: Ulrasound Vibroelastography (UVE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Adefovir Plus Vaccination in Transplant Patients Without Hepatitis B That Receive a Core Antibody Positive Liver
Status: COMPLETED
Conditions: Hepatitis B|Liver Transplantation
Interventions: DRUG: Adefovir dipivoxil and hepatitis B vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of PT-Cy at a Dose of 25 mg/kg/Day and PT-Cy at a Dose of 50 mg/kg/Day in GVHD Prophylaxis
Status: NOT_YET_RECRUITING
Conditions: Graft Versus Host Disease|Hematologic Malignancy|Cyclophosphamide Adverse Reaction
Interventions: DRUG: Post-transplantation Cyclophosphamide at dose 25 mg/kg/day|DRUG: Post-transplantation Cyclophosphamide at dose 50 mg/kg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Capecitabine, Vinorelbine, and Trastuzumab in Treating Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: trastuzumab|DRUG: capecitabine|DRUG: vinorelbine tartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: What is the Optimal Technique for Hydrodistention?
Status: ENROLLING_BY_INVITATION
Conditions: Interstitial Cystitis|Bladder Pain Syndrome
Interventions: PROCEDURE: Hydrodistention during cystoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemical Profiling of Colorectal and Pancreatic Cancers Using Breath Analysis - Feasibility Study
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer|Pancreatic Cancer
Interventions: DIAGNOSTIC_TEST: VOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact Evaluation of the DFID Programme to Accelerate Improved Nutrition of the Extreme Poor in Bangladesh
Status: COMPLETED
Conditions: Child Nutritional Status|Household Dietary Diversity|Maternal Nutrition Knowledge and Practices
Interventions: BEHAVIORAL: CLP: Livelihoods|DIETARY_SUPPLEMENT: CLP: Nutrition|BEHAVIORAL: Shiree: Livelihoods|DIETARY_SUPPLEMENT: Shiree: Nutrition|BEHAVIORAL: UPPR: Livelihoods|DIETARY_SUPPLEMENT: UPPR: Nutrition|OTHER: UPPR: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Learn About the Taste of Vericiguat Given in Liquid Form in Healthy Male Participants Aged 18 to 45 Years
Status: RECRUITING
Conditions: Heart Failure
Interventions: DRUG: Formulation 1|DRUG: Formulation 2|DRUG: Formulation 3|DRUG: Formulation 4|DRUG: Formulation 5 (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Decitabine Maintenance in Elderly Acute Myeloid Leukemia Patients
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|AML
Interventions: DRUG: Decitabine (Dacogen)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FluMist in Egg Allergic Patients
Status: COMPLETED
Conditions: Egg Allergy|Eligible for Vaccination Against Influenza
Interventions: BIOLOGICAL: FluMist intranasal influenza vaccine|BIOLOGICAL: Intramuscular influenza injection ("flu shot")
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase I Study to Evaluate the PK and PD of a Single Injection of Levonorgestrel Butanoate for Female Contraception
Status: COMPLETED
Conditions: Contraceptive Usage
Interventions: BIOLOGICAL: levonorgestrel butanoate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Control of Cognition (Naltrexone, Methylphenidate, and ADHD Study (NMAS))
Status: COMPLETED
Conditions: Healthy|Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Methylphenidate|DRUG: Naltrexone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Non-Interruptive Alerts for Improving Use of Clinical Decision Rules
Status: COMPLETED
Conditions: Pulmonary Embolism|Deep Vein Thrombosis|Minor Head Injury|Chest Pain|Neck Trauma
Interventions: OTHER: Clinical Decision Rule Alerts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Safety and Efficacy of a Combination of Favezelimab (MK-4280) and Pembrolizumab (MK-3475) in Participants With Hematologic Malignancies (MK-4280-003)
Status: RECRUITING
Conditions: Hodgkin Disease|Lymphoma, Non-Hodgkin|Lymphoma, B-Cell
Interventions: BIOLOGICAL: pembrolizumab|BIOLOGICAL: Favezelimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Guselkumab in Active Psoriatic Arthritis Participants With Inadequate Response/Intolerance to One Prior Anti-TNF Alpha Agent
Status: ACTIVE_NOT_RECRUITING
Conditions: Arthritis, Psoriatic
Interventions: DRUG: Guselkumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interventions to Control Hypersensitivity Pain in Teeth With Insisive Molar Hypomineralization
Status: NOT_YET_RECRUITING
Conditions: Molar Incisor Hypomineralization
Interventions: DRUG: Fluoride Varnishes|DRUG: Varnishes placebo|RADIATION: Low-Intensity Laser 1J|RADIATION: Low-Intensity Laser 2J
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Radiation Therapy With or Without Surgery in Treating Patients With Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: cisplatin|RADIATION: Standard fractionation RT|RADIATION: Accelerated fractionation radiation therapy|PROCEDURE: Conventional surgery for select patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ISIS 301012 (Mipomersen) in Heterozygous Familial Hypercholesterolemia Subjects on Lipid Lowering Therapy
Status: COMPLETED
Conditions: Hypercholesterolemia, Familial
Interventions: DRUG: ISIS 301012 or Placebo|DRUG: ISIS 301012 or Placebo|DRUG: ISIS 301012 or Placebo|DRUG: ISIS 301012 or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Complex Intervention Study on a Palliative Rehabilitation Blended Learning Program to Support Relatives and Health Care Providers of People With ALS and Cognitive Impairments in Coping With Challenges
Status: COMPLETED
Conditions: Relatives|Health Care Providers|Cognitive Impairment|Rehabilitation
Interventions: OTHER: EMBRACE (relatives)|OTHER: EMBRACE (Health care providers)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assess Pharmacokinetics of Fostamatinib in Fed and Fasted State in Combination With Ranitidine to Assess Bioavailability
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Fostamatinib - 1 x 150mg mannitol-based 38% drug-loaded tablet(orange reference)|DRUG: Fostamatinib - 3 x 50mg microcrystalline cellulose-based 13% drug loaded tablets,(blue) fed|DRUG: Fostamatinib - 1 x 150mg mannitol based 38% drug-loaded tablet (batch variant A)|DRUG: Fostamatinib - 1 x 150mg mannitol based 38% drug loaded tablet (batch variant B)|DRUG: Ranitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Wobenzym PS on Inflammation
Status: COMPLETED
Conditions: Sub-clinical Inflammation
Interventions: DIETARY_SUPPLEMENT: Wobenzym PS|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Surgery on the Treatment of Supratentorial Malignant Gliomas in Subjects Aged 70 and Over
Status: COMPLETED
Conditions: Malignant Glioma
Interventions: PROCEDURE: Surgery|RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lactobacillus Reuteri DSM 17938 in Preventing Nosocomial Diarrhea in Children
Status: COMPLETED
Conditions: Diarrhea
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri DSM 17938|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Equivalence of Generic Pimecrolimus Cream 1% and Elidel® 1% in Subjects With Mild to Moderate Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Pimecrolimus Cream 1% (Valeant)|DRUG: Vehicle cream|DRUG: Pimecrolimus Cream, 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intratumoural Injection of a Novel NanoZolid®-Docetaxel Depot Formulation in Patients With Advanced Solid Tumours
Status: TERMINATED
Conditions: Solid Tumor
Interventions: DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Bmab 1000 and Prolia® in Normal Healthy Volunteers: DENARIUS: DENosumab Pharmacokinetic equivAlence tRIal in Healthy volUnteerS
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: Bmab 1000|BIOLOGICAL: Prolia®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Treatment-Option Protocol to Provide Brentuximab Vedotin to Eligible Patients Completing Studies SGN35-005 or C25001
Status: NO_LONGER_AVAILABLE
Conditions: Disease, Hodgkin|Lymphoma, Large-Cell, Anaplastic|Lymphoma, Non-Hodgkin|Lymphoma, T-Cell, Cutaneous
Interventions: DRUG: brentuximab vedotin
Study Type: EXPANDED_ACCESS