pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Reduction of Inappropriate Shocks of Implantable Cardioverter Defibrillators (ICDs) With Enhanced SVT Discriminators
Status: COMPLETED
Conditions: Tachycardia
Interventions: DEVICE: ICD with enhanced SVT discriminators
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib in Treating Patients With High-Risk Acute Myeloid Leukemia in Remission
Status: TERMINATED
Conditions: Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Promyelocytic Leukemia (M3)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Secondary Acute Myeloid Leukemia
Interventions: DRUG: bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Carboplatin/Paclitaxel/Bevacizumab in the Treatment of Advanced Stage Endometrial Carcinoma
Status: COMPLETED
Conditions: Endometrial Cancer
Interventions: DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine vs Propofol Sedation Reduces Postoperative Delirium in Patients Receiving Hip Arthroplasty.
Status: COMPLETED
Conditions: Anesthesia|Local Anesthesia
Interventions: DRUG: propofol|DRUG: dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Behavioural Activation Therapy and Esketamine for Resistant Depression
Status: RECRUITING
Conditions: Depressive Disorder, Treatment-Resistant|Depressive Disorder, Major|Bipolar Disorder
Interventions: BEHAVIORAL: Behavioural Activation (BA) Therapy|DRUG: Esketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase Ⅰb/Ⅱ Study of HS-10506 in Chinese Participants With Insomnia Disorder
Status: NOT_YET_RECRUITING
Conditions: Insomnia Disorder
Interventions: DRUG: HS-10506|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial of The Effectiveness of Aromatherapy on Chemotherapy Induced Nausea and Vomiting in Children With Cancer
Status: COMPLETED
Conditions: Brain Tumors|Leukemia|Sarcomas|Neuroblastoma|Lymphoma|Hodgkins Disease
Interventions: OTHER: Aromatherapy Scented Wand|OTHER: Placebo wand
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Oral Mucosal Effects In Adult Smokers Associated With Two Nicotine Lozenge Formulations
Status: COMPLETED
Conditions: Safety Issues
Interventions: DRUG: Nicotine Bitartrate Lozenge 4mg|DRUG: Nicotine Polacrilex 4Mg Lozenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vestibular Stimulation to Trigger Adipose Loss (VeSTAL) Clinical Trial
Status: COMPLETED
Conditions: Obesity
Interventions: DEVICE: VeSTAL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Pilot Study of Multi-actor Tolerance Evaluation Using the VIRARE Device (VIrtual Reality Assisted Rehabilitation) in Visually Impaired Patients
Status: COMPLETED
Conditions: Visual Impairment
Interventions: DEVICE: Virtual reality tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: RCT of Olanzapine for Control of CIV in Children Receiving Highly Emetogenic Chemotherapy
Status: RECRUITING
Conditions: Vomiting in Infants and/or Children|Nausea|Hematopoietic System--Cancer|Oncology
Interventions: DRUG: Olanzapine|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Weighted Vaginal Cones Versus Biofeedback in the Treatment of Urodynamic Stress Incontinence: a Randomized Trial.
Status: TERMINATED
Conditions: Urinary Incontinence, Stress
Interventions: BEHAVIORAL: weighted vaginal cones|BEHAVIORAL: Biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Tolerability, PK and PD of ALXN1007 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ALXN1007|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ADDIA Proof-of-Performance Clinical Study
Status: UNKNOWN
Conditions: Alzheimer Disease (AD)|Frontotemporal Lobar Degeneration|Dementia With Lewy Bodies (DLB)|Parkinson Disease Dementia (PDD)|Progressive Supranuclear Palsy (PSP)|Corticobasal Degeneration (CBD)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preventing TB-IRIS in High-risk Patients: a Randomized Placebo-controlled Trial of Prednisone
Status: COMPLETED
Conditions: Immune Reconstitution Inflammatory Syndrome|HIV|Tuberculosis
Interventions: DRUG: Prednisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Clinical Outcomes in Hunter Syndrome Patients 5 Years of Age and Younger Receiving Idursulfase Therapy
Status: COMPLETED
Conditions: Hunter Syndrome|Mucopolysaccharidosis II|MPS II
Interventions: BIOLOGICAL: Idursulfase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential and Hybrid Therapies for H Pylori Infection
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: 14-day sequential treatment|DRUG: 14-day hybrid treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on the Effectiveness of Laparoscopic Fundoplication on Extraesophageal Manifestations of Gastroesophageal Reflux Disease (GERD)
Status: COMPLETED
Conditions: Extraesophageal Symptoms|Gastroesophageal Reflux Disease (GERD)
Interventions: PROCEDURE: Laparoscopic anti-reflux surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Safety and Efficacy of the Inspiromatic Inhaler in Comparison to the Aerolizer Inhaler When Delivering Formoterol
Status: UNKNOWN
Conditions: Asthma
Interventions: DEVICE: Aerolizer Followed by Inspiromatic|DEVICE: Inspiromatic followed by Aerolizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cue-Based Vs. Clinician-Driven Feeding in Very Low Birthweight Infants
Status: NOT_YET_RECRUITING
Conditions: Infant, Very Low Birth Weight|Infant Development|Feeding Patterns
Interventions: BEHAVIORAL: Cue-based feedings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virucidal Effect of PVP-I on COVID-19 and as Well as Safety of Its Application on Nasopharynx & Oropharynx
Status: COMPLETED
Conditions: Virus Infection, RNA|Effect of Drug|Efficacy, Self
Interventions: DRUG: 0.6% PVP-I oral and nasal spray to moderately ill COVID-19 positive patient|DRUG: 0.6% PVP-I Oral and nasal spray to asymptomatic to mild COVID-19 patient having multiple comorbidity|DRUG: 0.6% PVP-I Oral and nasal spray to healthy volunteer|OTHER: Oral and nasal spray by distilled water to control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability and Pharmacokinetics Study of MK-7252 in Healthy Adult Participants (MK-7252-001)
Status: COMPLETED
Conditions: Pharmacokinetics|Cancer
Interventions: DRUG: MK-7252|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Diphenhydramine Hydrochloride Effects in Subjects With Occasional Sleeplessness
Status: COMPLETED
Conditions: Occasional Sleeplessness
Interventions: DRUG: Diphenhydramine Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Hemp-containing Cream Versus Placebo in the Treatment of Uremic Pruritus
Status: COMPLETED
Conditions: Uremic Pruritus
Interventions: DRUG: Hemp|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating RELEARN Neurofeedback as Treatment for Chronic Musculoskeletal Pain
Status: WITHDRAWN
Conditions: Chronic Knee Pain|Chronic Pain|Osteoarthritis
Interventions: DEVICE: RELEARN Neurofeedback|OTHER: Standard care control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Different Training Programs in Chronic Disease Patients
Status: UNKNOWN
Conditions: Hypertension|Hypertension Complicated With Type 2 Diabetes|Walking|Chinese Square Dancing
Interventions: BEHAVIORAL: Walking group|BEHAVIORAL: Chinese square dancing group|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Non-pharmacological Novel Cognitive Interventions on Motor-Cognitive Function in Children With ADHD
Status: UNKNOWN
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DEVICE: Virtual Reality training|OTHER: Computerized Cognitive Remediation|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Microelectrode Recordings From the Vagus Nerve in Awake Humans
Status: RECRUITING
Conditions: Epilepsy
Interventions: OTHER: VNS stimulation and intraneural recordings|OTHER: Record multi-unit activity from intraneural sites
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Branched-chain Aminoacids in Sleep Apnea Syndromes (ARSAS)
Status: WITHDRAWN
Conditions: Sleep Apnea
Interventions: DRUG: Branched-chain aminoacids|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Neuroplasticity and Frontal Lobe Function in Patients With Mild Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: PROCEDURE: Paired Associative Stimulation|PROCEDURE: Paired Associative Stimulation-Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Community Health Workers United to Reduce Colorectal Cancer and Cardiovascular Disease Among People at Higher Risk
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: BEHAVIORAL: SBIRT|BEHAVIORAL: Referral as Usual (RAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Metabolism of Anthocyanins and Heart Health
Status: TERMINATED
Conditions: Healthy
Interventions: OTHER: Freeze dried blueberry powder|OTHER: Anthocyanin free, sugar-matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immunotherapy Platform Study in Platinum Resistant High Grade Serous Ovarian Cancer
Status: RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: Durvalumab|DRUG: BA3011|DRUG: BA3021|DRUG: To be determined
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benefits of Adapted Physical Activity for Chronic Osteoarticular Pain in Patients With Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma|Adapted Physical Activity|Chronic Pain
Interventions: OTHER: adapted physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Esomeprazole Plus Alginate vs. Esomeprazole Alone for Treatment of Nighttime Reflux Symptom and Sleep Disturbances
Status: UNKNOWN
Conditions: Gastroesophageal Reflux Disease|Heartburn|Sleep Disturbance
Interventions: DRUG: sodium alginate|DRUG: esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Stent Versus Direct Atherectomy to Treat Arteriosclerosis Occlusive Disease of Lower Extremity
Status: COMPLETED
Conditions: Atherosclerosis|Ischemia
Interventions: DEVICE: plaque excision system|DEVICE: balloon and Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Lidocaine - Prilocaine Cream (EMLA) Versus Mepivacaine Infiltration on Pain Relief During And After Mediolateral Episiotomies
Status: UNKNOWN
Conditions: Episiotomy Pain
Interventions: DRUG: Lidocaine-prilocaine cream|DRUG: mepivacaine infiltration group|PROCEDURE: mediolateral episiotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Mismatched Donor Lymphocyte Infusions for Relapsed Disease Following Allogeneic Stem Cell Transplantation
Status: COMPLETED
Conditions: Leukemia, Myeloid, Acute|Leukemia, Lymphoblastic, Acute|Leukemia, Myelocytic, Chronic
Interventions: DEVICE: Miltenyi Magnetic cell sorter for CD3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Bevacizumab Therapy in Patients With Newly Diagnosed High-Grade Gliomas and Diffuse Intrinsic Pontine Gliomas
Status: COMPLETED
Conditions: Newly Diagnosed High-Grade Gliomas|Diffuse Intrinsic Pontine Glioma
Interventions: DRUG: Temozolomide|DRUG: Bevacizumab|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Iptacopan in Participants With IC-MPGN
Status: RECRUITING
Conditions: IC-MPGN
Interventions: DRUG: Placebo|DRUG: iptacopan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preventive Physiotherapy Intervention in Elderly People With Sarcopenia
Status: COMPLETED
Conditions: Sarcopenia|Syndrome; Institutionalization
Interventions: OTHER: Inspiratory Muscle Training (IMT).|OTHER: Peripheral muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ascorbic Acid Administration in the Treatment of Anemia in Chronic Hemodialysed Patients
Status: UNKNOWN
Conditions: Anaemia Response to the Treatment|Peripheral Iron Indices|Oxalemia
Interventions: DRUG: Ascorbic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of the Use of Low Intensity Therapeutic LASER
Status: RECRUITING
Conditions: Wound|Diabetic Foot|LTBI
Interventions: DEVICE: CC|DEVICE: LG1|DEVICE: LG2|DEVICE: LG3|PROCEDURE: Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Randomized Trial of Diphenhydramine Versus Continued Midazolam in "Difficult-to-sedate" Patients Undergoing Colonoscopy
Status: COMPLETED
Conditions: Sedation|Endoscopy
Interventions: DRUG: Diphenhydramine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trop-Shock DFT-testing Versus None
Status: COMPLETED
Conditions: Defibrillation Testing - ICD Therapy Optimisation
Interventions: DEVICE: ICD Implantation without DFT testing|DEVICE: Upper limit of vulnerability testing|DEVICE: T-wave shock with induction of ventricular fibrillation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerance of Potassium Hydroxide (10% and 15%) in Molluscum Contagiosum
Status: COMPLETED
Conditions: Molluscum Contagiosum
Interventions: DRUG: Hydroxide Potassium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nasal Budesonide in Children With Rhinitis and/or Mild Obstructive Sleep Apnea Syndrome
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: Budesonide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Eletroestimulation in Torque for Long Distance Recreational Runners
Status: COMPLETED
Conditions: Torque
Interventions: OTHER: NMES and Run|OTHER: Only Run
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MK0476 Study in Adult Patients With Allergic Rhinitis (0476-378)
Status: COMPLETED
Conditions: Rhinitis Allergic
Interventions: DRUG: MK0476, montelukast sodium / Duration of Treatment: 2 Weeks|DRUG: Comparator: placebo / Duration of Treatment: 2 Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tooth Whitening With Hydrogenperoxide in Adolescents
Status: UNKNOWN
Conditions: Posteruptive Color Change of Tooth
Interventions: OTHER: Placebo gel without hydrogen peroxide|OTHER: 6.0% hydrogen peroxide - White Class|OTHER: 7.5% hydrogen peroxide - White Class|OTHER: 7.5% hydrogen peroxide - Oral-B 3D White
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Management of Dyspnea: Use of Hand Held Fan
Status: COMPLETED
Conditions: Lung Cancer
Interventions: OTHER: hand-held fan airflow stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Self Medication With Oral Morphine After Total Knee Arthroplasty.
Status: COMPLETED
Conditions: Arthroplasty, Knee Replacement|Pain Control
Interventions: BEHAVIORAL: Nurse dispensed oral morphine.|BEHAVIORAL: Patient self medication of oral morphine.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of BDTX-1535 in Recurrent High-Grade Glioma (HGG) Participants With EGFR Alterations or Fusions
Status: RECRUITING
Conditions: High Grade Glioma
Interventions: DRUG: BDTX-1535
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bicalutamide Compared With Observation Followed by Bicalutamide Plus Either Goserelin or Orchiectomy in Treating Patients With Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: bicalutamide|DRUG: goserelin acetate|PROCEDURE: orchiectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: CAR T Cell Receptor Immunotherapy Targeting Mesothelin for Patients With Metastatic Cancer
Status: TERMINATED
Conditions: Cervical Cancer|Pancreatic Cancer|Ovarian Cancer|Mesothelioma|Lung Cancer
Interventions: DRUG: Fludarabine|BIOLOGICAL: Anti-mesothelin chimeric T cell receptor (CAR) transduced peripheral blood lymphocytes (PBL)|DRUG: Cyclophosphamide|DRUG: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of LX3305 and Methotrexate in Subjects With Stable Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: LX3305|DRUG: LX3305 Placebo|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Effectiveness of Ustekinumab in Patients With Psoriatic Arthritis
Status: COMPLETED
Conditions: Arthritis, Psoriatic
Interventions: DRUG: Placebo|DRUG: Ustekinumab 45 mg|DRUG: Ustekinumab 90 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemotherapy in Advanced Epithelial Ovarian Cancer (EOC): A Phase III Randomized Study
Status: UNKNOWN
Conditions: Ovarian Carcinoma
Interventions: OTHER: timing of surgery|OTHER: timing of surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spinal Cord Injury Exercise and Nutrition Conceptual Engagement
Status: COMPLETED
Conditions: Spinal Cord Injuries|Metabolic Syndrome|Dietary Modification|Paraplegia|Tetraplegia
Interventions: DEVICE: Functional Electrical Stimulation Leg Cycle Ergometry|BEHAVIORAL: Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Test-Retest Reliability of oVEMP's Across Different Electrode Montages
Status: WITHDRAWN
Conditions: Vestibular Abnormality|Vestibular Nerve Disorders
Interventions: DIAGNOSTIC_TEST: oVEMP - infra-orbital electrode montage|DIAGNOSTIC_TEST: oVEMP - belly-tendon electrode montage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude
Status: COMPLETED
Conditions: Hypertension, Pulmonary|Altitude Sickness
Interventions: DRUG: Riociguat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Adverse Events of Bilateral Single-shot VC/VS Gamma Capsulotomy for OCD: a Pilot Study
Status: UNKNOWN
Conditions: Obsessive-compulsive Disorder
Interventions: PROCEDURE: Gamma Ventral Capsulotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Mentorship to Support Maternal and Infant Health and Wellbeing: Assessing the Impact and Efficacy of NurturePA
Status: COMPLETED
Conditions: Mothers
Interventions: BEHAVIORAL: Text-based mentorship|BEHAVIORAL: Control text messaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of CDX-6114 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CDX-6114|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fluticasone Furoate/GW642444 Inhalation Powder Long-Term Safety Study
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone Furoate/GW642444|DRUG: Fluticasone propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Family-Based Versus Individual Psychotherapy in Treating Adolescents With Anorexia Nervosa
Status: COMPLETED
Conditions: Eating Disorders
Interventions: BEHAVIORAL: Family Based Therapy|BEHAVIORAL: Ego-Oriented Individual Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erlotinib Hydrochloride in Treating Non-Small Cell Lung Cancer That is Metastatic or Cannot be Removed by Surgery in Patients With HIV Infection
Status: TERMINATED
Conditions: HIV Infection|Recurrent Non-Small Cell Lung Carcinoma|Stage IIIA Non-Small Cell Lung Cancer|Stage IIIB Non-Small Cell Lung Cancer|Stage IV Non-Small Cell Lung Cancer
Interventions: DRUG: Erlotinib Hydrochloride|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Nursing Counseling Perceived Stress, Coping and Birth Outcomes Among Pregnant Women
Status: COMPLETED
Conditions: Preterm Birth
Interventions: OTHER: NPECP based on NSM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Measuring Individual Responses to a Wholegrains and Nuts Intervention to Reduce Blood Pressure in Prehypertension
Status: COMPLETED
Conditions: Prehypertension
Interventions: OTHER: Dietary intervention: nuts and wholegrains with dietary advice for a blood-pressure lowering diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: To Evaluate the Efficacy and Safety of Collavant n2 in Individuals With Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: OTHER: Collavant n2 40 mg/day|OTHER: Glucosamine hydrochloride & Chondroitin sulfate|OTHER: Microcrystalline cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sunitinib Malate or Valproic Acid in Preventing Metastasis in Patients With High-Risk Uveal Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Ciliary Body and Choroid Melanoma, Medium/Large Size|Ciliary Body and Choroid Melanoma, Small Size|Iris Melanoma|Stage I Intraocular Melanoma|Stage IIA Intraocular Melanoma|Stage IIB Intraocular Melanoma|Stage IIIA Intraocular Melanoma|Stage IIIB Intraocular Melanoma|Stage IIIC Intraocular Melanoma|Stage I Uveal Melanoma AJCC V7|Stage II Uveal Melanoma AJCC V7|Stage III Uveal Melanoma AJCC V7
Interventions: DRUG: Sunitinib|DRUG: Valproic Acid|DRUG: Sunitinib Malate|DRUG: Sunitinib Malate + Valproic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SMART Program in Irritable Bowel Syndrome (IBS)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: BEHAVIORAL: Stress Management and Resilience Training Program|BEHAVIORAL: Self-Management Stress Reduction Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MT10109L in the Long-term, Open-label Treatment of Glabellar Lines (GL) and Lateral Canthal Lines (LCL)
Status: COMPLETED
Conditions: Glabellar Lines|Lateral Canthal Lines
Interventions: DRUG: MT10109L Dose 1|DRUG: MT10109L Dose 2|DRUG: MT10109L Dose 1 + Dose 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose-Escalation Study to Determine the Maximum Tolerated Dose of Arbaclofen Placarbil in Subjects With Alcohol Use Disorder
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: DRUG: Arbaclofen Placarbil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Insulin Administration at Cardiac Surgery for Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus|Cardiac Event
Interventions: DRUG: Fast-acting human insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Body-mass Index (BMI) on Median Effective Dose of Intrathecal Hyperbaric Bupivacaine
Status: COMPLETED
Conditions: Arthroplasty, Knee
Interventions: DRUG: BPV6NO|DRUG: BPV7NO|DRUG: BPV8NO|DRUG: BPV9NO|DRUG: BPV10NO|DRUG: BPV11NO|DRUG: BPV6O|DRUG: BPV7O|DRUG: BPV8O|DRUG: BPV9O|DRUG: BPV10O|DRUG: BPV11O
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Massed Prolonged Exposure for PTSD in Substance Use Treatment
Status: NOT_YET_RECRUITING
Conditions: Stress Disorders, Post-Traumatic|Substance Use Disorders
Interventions: BEHAVIORAL: Prolonged Exposure Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FAM (Follower, Action Plan, and Remote Monitoring) Intervention to Reduce Severe Hyperglycemia in Adults With Type 1 Diabetes Mellitus at Risk for Diabetic Ketoacidosis
Status: RECRUITING
Conditions: Type 1 Diabetes
Interventions: DEVICE: FAM intervention consisting of a Follower of glucose data, Action Plan, and Remote Monitoring of glucose data|OTHER: standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of the Efficacy and Safety of Continuous and Single-Dose Intravesical Epirubicin Instillation
Status: RECRUITING
Conditions: Bladder Cancer|Epirubicin Adverse Reaction|Superficial Bladder Cancer|Tumor Recurrence
Interventions: DRUG: Intravesical Solution|DRUG: Intravesical Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of BRIMOCHOL™ PF and Carbachol PF in Subjects With Emmetropic Phakic and Pseudophakic Presbyopia
Status: ACTIVE_NOT_RECRUITING
Conditions: Presbyopia
Interventions: DRUG: BRIMOCHOL™ PF|DRUG: Carbachol PF|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pregnenolone and L-theanine Augmentation in the Treatment for Schizophrenia and Schizoaffective Disorders
Status: UNKNOWN
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DIETARY_SUPPLEMENT: Pregnenolone and L-Theanine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementing Oral (Event-driven and Daily) and Long-acting Pre-Exposure Prophylaxis in Mobile Men in Sub-Saharan Africa
Status: NOT_YET_RECRUITING
Conditions: HIV
Interventions: DRUG: Tenofovir disoproxil fumarate/emtricitabine (TDF-FTC), cabotegravir (CAB-LA)|DRUG: Cabotegravir (CAB-LA), Tenofovir disoproxil fumarate/emtricitabine (TDF-FTC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Lay Coach-Led Early Palliative Care for Underserved Advanced Cancer Caregivers: The Project ENABLE Cornerstone RCT
Status: RECRUITING
Conditions: Cancer Metastatic|Family Members
Interventions: BEHAVIORAL: ENABLE Cornerstone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Effectiveness and Safety Study of Two Doses of Acetaminophen Extended Release Caplets in the Treatment of Osteoarthritis of the Hip or Knee
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: acetaminophen extended release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: LESs Surgical Radicality for EaRly Stage Cervical Cancer
Status: COMPLETED
Conditions: Uterine Cervical Neoplasms
Interventions: PROCEDURE: Extrafascial Hysterectomy|PROCEDURE: Modified radical hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on the Safety and Efficacy of BRL-101 in the Treatment of Sickle Cell Disease
Status: NOT_YET_RECRUITING
Conditions: Sickle Cell Disease
Interventions: DRUG: BRL-101 autologous hematopoietic stem and progenitor cells injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preconditioning Shields Against Vascular Events in Surgery
Status: UNKNOWN
Conditions: Abdominal Aortic Aneurysm|Carotid Atherosclerosis|Critical Lower Limb Ischaemia
Interventions: PROCEDURE: Remote ischaemic preconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Computational Model of SNS (Sacral Nerve Stimulation) Induced Electrical Current Flow Using Tractography Imaging
Status: COMPLETED
Conditions: Faecal Incontinence
Interventions: RADIATION: CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Compare Between the Effect of Topical Tranexamic Acid Versus Hydrogen Peroxide on Blood Loss in Spine Surgeries
Status: UNKNOWN
Conditions: Blood Loss
Interventions: DRUG: Topical Solution|DRUG: Topical Foam|OTHER: Topical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evidence-based Physical Therapy in Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: No intervention, no follow-up, only registration|OTHER: Intervention period
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ipilimumab and Nivolumab With Immunoembolization in Treating Participants With Metastatic Uveal Melanoma in the Liver
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Malignant Neoplasm in the Liver|Metastatic Uveal Melanoma|Stage IV Uveal Melanoma AJCC v7
Interventions: BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab|DRUG: Embolization Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare the Properties and Characteristics of an Investigational Formulation of Lamotrigine With Placebo
Status: COMPLETED
Conditions: Mental Disorders
Interventions: DRUG: Cherry lamotrigine ODT|DRUG: Cherry Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RECOVER-SLEEP: Platform Protocol
Status: RECRUITING
Conditions: Long COVID|Long COVID-19|Hypersomnia|Sleep Disturbance
Interventions: DRUG: Modafinil|DRUG: Modafinil Placebo|DRUG: Solriamfetol|DRUG: Solriamfetol Placebo|DRUG: Melatonin|DRUG: Melantonin Placebo|DEVICE: Tailored lighting (TL) Active|DEVICE: Tailored lighting (TL) Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety, Tolerability and Pharmacokinetic Study of Litapiprant Tablets in Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Litapiprant Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Food Study of Modafinil Tablets 200 mg to Provigil® Tablets 200 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Modafinil Tablets 200 mg|DRUG: Provigil® Tablets 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: BGJ398 in Non-Muscle-Invasive Urothelial Carcinoma of the Bladder
Status: ACTIVE_NOT_RECRUITING
Conditions: Bladder Cancer|Non-Muscle-Invasive Urothelial Carcinoma
Interventions: DRUG: BGJ398
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Elastography in Diffferentiation of Endometriomas and Hemorrhagic Cysts
Status: UNKNOWN
Conditions: Ovarian Endometrioma
Interventions: DEVICE: ultrasound elastography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Different Combination Regimens Including JNJ-73763989 and/or JNJ-56136379 for the Treatment of Chronic Hepatitis B Virus Infection
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: JNJ-73763989|DRUG: Placebo for JNJ-73763989|DRUG: JNJ-56136379|DRUG: Placebo for JNJ-56136379|DRUG: Nucleos(t)ide Analog (NA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Digital Life Coaching in Myeloma Patients Undergoing Transplantation
Status: COMPLETED
Conditions: Multiple Myeloma|Stem Cell Transplant
Interventions: BEHAVIORAL: Pack Health's Digital Life Coaching (DLC)|OTHER: Electronic Handouts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of PCSK9 Inhibitor AK102 in Healthy Subjects
Status: COMPLETED
Conditions: Hypercholesterolaemia
Interventions: DRUG: AK102|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aromatherapy Effect on Anxiety Prior to Ultrasound Guided Musculoskeletal Procedures
Status: RECRUITING
Conditions: Anxiety State
Interventions: OTHER: Aromatherapy|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Long-term Safety of Rusfertide (PTG-300) in Subjects With Polycythemia Vera
Status: ENROLLING_BY_INVITATION
Conditions: Polycythemia Vera
Interventions: DRUG: Open-label rusfertide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictive and Prognostic Significance of Age,Blood Tests,Comorbidities(ABC) Score,Cologne Watch(C-watch)Score and Rockall Score for Risk of Variceal Re-bleeding Among Cirrhotic Patients
Status: RECRUITING
Conditions: Upper Gastrointestinal Variceal Bleeding in Cirrhotic Patients
Interventions: DIAGNOSTIC_TEST: upper endoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of Electrical Stimulation Gait Training on Walking and Posture for Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: BEHAVIORAL: Walking Practice with Functional Electrical Stimulation|BEHAVIORAL: Walking Practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Targeted Shortwave Diathermy Combined With Perceptual Training for Patients With Severe Traumatic Optic Neuropathy
Status: UNKNOWN
Conditions: Traumatic Optic Neuropathy
Interventions: PROCEDURE: Rehabilitation: shortwave diathermy and perceptual training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Herceptin (Trastuzumab) in Combination With Whole Brain Radiotherapy in Patients With HER-2 Positive Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: trastuzumab [Herceptin]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Dexmedetomidine in Light to Moderate Sedation in the Patient in the Palliative Situation of a Sars-cov-2 / COVID-19 Infection
Status: WITHDRAWN
Conditions: COVID-19 Infection|Sars-cov-2|Respiratory Failure|Palliative Situation
Interventions: DRUG: Treatment with Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Senolytic Drugs Attenuate Osteoarthritis-Related Articular Cartilage Degeneration: A Clinical Trial
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DIETARY_SUPPLEMENT: Fisetin|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate in Treating Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma|Skin Neoplasms
Interventions: DRUG: Imatinib mesylate (STI571)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Eribulin Mesylate and Ixabepilone in Causing or Exacerbating Neuropathy in Participants With Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Eribulin Mesylate|DRUG: Ixabepilone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study to Evaluate MT-6548 in Peritoneal Dialysis Subjects With Anemia Associated With Chronic Kidney Disease in Japan
Status: COMPLETED
Conditions: Anemia; Peritoneal Dialysis Dependent Chronic Kidney Disease
Interventions: DRUG: MT-6548
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of RSLV-132 in Subjects With Primary Sjogren's Syndrome
Status: COMPLETED
Conditions: Sjogren's Syndrome
Interventions: DRUG: RSLV-132|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Web-based Psycho-Educational Program to Support Carers of Alzheimer's Patients
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: BEHAVIORAL: psycho-social intervention based on a web-based psycho-educational program, called Diapason.|BEHAVIORAL: Consultation in memory clinic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomized Controlled Trial to Assess the Effects of Sapropterin on Hepatic and Systemic Hemodynamics in Patients With Liver Cirrhosis and Portal Hypertension
Status: COMPLETED
Conditions: Liver Cirrhosis|Portal Hypertension
Interventions: DRUG: sapropterin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of PF-04523655 (REDD14NP) In Subjects With Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (Wet AMD)
Status: COMPLETED
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: PF-04523655
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Safety and Immunogenicity of Recombinant HIV-1 Envelope Protein SOSIP v8.2 763 Vaccine, Adjuvanted With MPLA Liposomes, in Healthy, HIV-Uninfected Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: BIOLOGICAL: 763SIP8/MPLA-5 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION