pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety of Tacrolimus Versus Mycophenolate in Lupus Nephritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Lupus Nephritis
Interventions: DRUG: Tacrolimus|DRUG: Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: R.CULT.HEA - URban Environment, CULTural Social Use of Space and HEAlth / Well-being Effect on Population
Status: UNKNOWN
Conditions: Personal Satisfaction|Health Behavior
Interventions: OTHER: Cultural and Social exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Testing the Role of FDG-PET/CT to Predict Response to Therapy Prior to Surgery for HER2-positive Breast Cancer, The DIRECT Trial
Status: RECRUITING
Conditions: Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|HER2-Positive Breast Carcinoma|Invasive Breast Carcinoma
Interventions: DRUG: Chemotherapy|PROCEDURE: Computed Tomography|OTHER: Fludeoxyglucose F-18|PROCEDURE: Positron Emission Tomography|PROCEDURE: Surgical Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical and Biological Efficacy of Mirasol-treated Fresh Whole Blood for the Prevention of Transfusion-transmitted Malaria
Status: COMPLETED
Conditions: Malaria
Interventions: DEVICE: Mirasol-treated Whole Blood|BIOLOGICAL: Untreated Whole Blood
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Proof-of-concept Study for SAR441344 (Frexalimab) in Relapsing Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: SAR441344 IV|DRUG: placebo IV|DRUG: SAR441344 SC|DRUG: placebo SC|DRUG: MRI contrast-enhancing preparations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Placement of the Double-Lumen Tube Without Fiberoptic Bronchoscope Assistance
Status: COMPLETED
Conditions: Therapeutic Procedural Complication
Interventions: DEVICE: laryngoscope and chest CT image|DEVICE: traditional method by experience
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lysergic Acid Diethylamide (LSD) as Treatment for Cluster Headache
Status: RECRUITING
Conditions: Cluster Headache
Interventions: DRUG: Lysergic Acid Diethylamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Disitamab Vedotin Combined With Tislelizumab and Capecitabine in the Perioperative Treatment of Locally Advanced Gastric Cancer With HER2 Overexpression
Status: RECRUITING
Conditions: Gastric Cancer|Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: combination with Disitamab Vedotin and with Tislelizumab and Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subjects With Non-Healing Venous Leg Ulcers Treated With Standard Care Plus Cryopreserved Human Umbilical Cord (TTAX01)
Status: COMPLETED
Conditions: Venous Leg Ulcer
Interventions: BIOLOGICAL: TTAX01|OTHER: Profore Compression Therapy|OTHER: Cadexomer Iodine dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Bone Marrow Mesenchymal Stem Cell Transplantation for Chronic Ischemic Stroke
Status: UNKNOWN
Conditions: Stroke
Interventions: GENETIC: Intravenous stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Home-Based Programs for Improving Sleep in Cancer Survivors
Status: TERMINATED
Conditions: Cancer Survivor|Fatigue|Psychosocial Effects of Cancer and Its Treatment|Sleep Disorders
Interventions: BEHAVIORAL: Home-based sleep intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Zoledronic Acid on Prevention of Bone Loss in Acute Phase First-ever Stroke Patients
Status: UNKNOWN
Conditions: Stroke
Interventions: DRUG: Zoledronic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pegaspargase Combined With Gemcitabine, Etoposide, Liposomal Mitoxantrone Hydrochloride and Dexamethasone (P-GEMD) in the Treatment of Untreated Early Non-upper Respiratory Tract or Advanced Extranodal NK/T-cell Lymphoma
Status: NOT_YET_RECRUITING
Conditions: NK-T-Cell Lymphoma, Extranodal
Interventions: DRUG: Pegaspargase Combined With Gemcitabine, Etoposide, Liposomal Mitoxantrone Hydrochloride and Dexamethasone (P-GEMD) regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Immunomodulator as an Adjunct Therapy in New Pulmonary Tuberculosis(Category I) Patients.
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: Intradermal injection of Mycobacterium w
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bristol-Myers Squibb Dasatinib Src Inhibition in Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Cancer
Interventions: DRUG: Dasatinib|DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Modulation of Attention in Event Related Potential (ERPs) as a Marker of Early Cognitive Decline by Ginkgo Biloba
Status: ACTIVE_NOT_RECRUITING
Conditions: Subjective Cognitive Decline|Cognitive Performance|Functional Capacity|Age-related Cognitive Decline
Interventions: DRUG: Ginkgo biloba extract|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Dasatinib in Combination With Melphalan and Prednisone to Treat Relapsed and Refractory Multiple Myeloma Patients
Status: TERMINATED
Conditions: Myeloma
Interventions: DRUG: dasatinib|DRUG: melphalan|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peak Plantar Pressures While Wearing a Carbon Fiber Off Loading Orthoses
Status: COMPLETED
Conditions: Diabetes Mellitus|Peripheral Neuropathy|Orthotic Device
Interventions: DEVICE: Carbon Fiber Off Loading Orthosis (CFO)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Efficacy and Safety of K-285 Compared With Menthol Gel for the Treatment of Delayed Onset Muscle Soreness (DOMS) in the Lower Extremity
Status: TERMINATED
Conditions: Acute Pain
Interventions: DRUG: K-285|DRUG: Menthol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endothelin Receptor Blockade in Acute ST-elevation Myocardial Infarction
Status: COMPLETED
Conditions: ST-Elevation Myocardial Infarction
Interventions: DRUG: Placebo|DRUG: BQ-123
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Technical Validation of MR Biomarkers of Obesity-Associated NAFLD
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease|Non-alcoholic Steatohepatitis
Interventions: OTHER: Magnetic Resonance Elastography (MRE)|DIAGNOSTIC_TEST: Liver biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Outcomes Study Comparing the Intralase FS 60 to the Intralase iFS When Performing LASIK Surgery for Nearsightedness
Status: COMPLETED
Conditions: Myopia|Astigmatism
Interventions: PROCEDURE: LASIK with the iFS femtosecond laser
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Application of a Mental Practice Protocol in the Acute Inpatient Rehabilitation Setting
Status: COMPLETED
Conditions: Stroke|Upper Extremity Paresis
Interventions: OTHER: Mental Practice|OTHER: Repetitive-Task Practice|OTHER: Traditional Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Safety Study of Arformoterol QD Dosing Versus BID Dosing in COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Arformoterol Tartrate Inhalation Solution|DRUG: Arformoterol Tartrate Inhalation Solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 12 Week Evaluation of the Safety and Efficacy of a Flexible Dose of CP-526,555 and Placebo for Smoking Cessation
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: CP-526,555 (varenicline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Opioid-induced Constipation in Patients With Advanced Cancer
Status: RECRUITING
Conditions: Constipation, Opioid-Induced
Interventions: DRUG: Macrogol Only Product in Oral Dose Form|DRUG: Magnesium hydroxide 724mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of PEP02 in Combination With 5-fluorouracil (5-FU) and Leucovorin (LV) in Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: PEP02|DRUG: 5-FU|DRUG: LV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of TAC-101 Combined With Transcatheter Arterial Chemoembolization (TACE) Versus TACE Alone in Japanese Patients With Advanced Hepatocellular Carcinoma
Status: TERMINATED
Conditions: Advanced Hepatocellular Carcinoma
Interventions: DRUG: TAC-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Patients With Chronic Hepatitis C Infected With HCV LVL G1 and Effect of Peg-Intron Plus Rebetol Treatment (Study P04793)
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: PegIntron|DRUG: Rebetol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Research Study to Determine Whether PD 0332991 May Be Effective in Treating Patients With Liver Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Hepatocellular Carcinoma|HCC|Liver Cancer
Interventions: DRUG: PD-0332991
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab in Metastatic Biliary Tract Cancer as Second-line Treatment After Failing to at Least One Cytotoxic Chemotherapy Regimen: Integration of Genomic Analysis to Identify Predictive Molecular Subtypes
Status: COMPLETED
Conditions: Biliary Tract Cancer
Interventions: DRUG: MK3475
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgery With or Without Lymph Node Removal in Treating Older Women With Stage I or Stage IIA Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: tamoxifen citrate|PROCEDURE: conventional surgery|RADIATION: radiation therapy|PROCEDURE: Axillary clearance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: From Fungus to Virus, Investigating the Safety and Efficacy of Terbinafine in Chronic Hepatitis B Patients
Status: RECRUITING
Conditions: Chronic Hepatitis b
Interventions: DRUG: Terbinafine|DRUG: Placebo|DRUG: Tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Project 4: ACHIEVE PATHFINDER
Status: RECRUITING
Conditions: Heart Failure
Interventions: OTHER: PAC provision at hospital discharge|OTHER: Control non-intervention; PAC without filter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I:Decitabine by Hepatic Arterial Infusion(HAI) in Unresectable Liver Metastases Colorectal Cancer (CRC)
Status: COMPLETED
Conditions: Liver Metastasis|Colorectal Cancer
Interventions: DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weight and Metabolic Effects of an Almond Enriched Hypocaloric, Low Fat Diet on Overweight and Obese Persons
Status: COMPLETED
Conditions: Obesity|Metabolic Syndrome X|Hyperlipidemia|Hypertension
Interventions: BEHAVIORAL: Almond enriched diet|BEHAVIORAL: Low fat caloric diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alcohol: Thiamine and or Magnesium 1
Status: COMPLETED
Conditions: Alcohol Withdrawal|Lactic Acidosis|Vitamin B1 Deficiency|Magnesium Deficiency|Wernicke Encephalopathy
Interventions: DRUG: Magnesium Sulfate|DRUG: Pabrinex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thrombolysis in STEMI Patients Compared With pPCI on Recanalization Time in the Context of the COVID-19 Outbreak.
Status: UNKNOWN
Conditions: STEMI - ST Elevation Myocardial Infarction
Interventions: DRUG: Thrombolytic|PROCEDURE: percutaneous coronary stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Evaluation of Lymphoma Patients Based on Artificial Intelligence and PET/MRI
Status: UNKNOWN
Conditions: Lymphoma|Non Hodgkin Lymphoma|Follicular Lymphoma
Interventions: DIAGNOSTIC_TEST: PET/MR scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Transdermal Nicotine and Melatonin Patches for Postoperative Pain Relief
Status: COMPLETED
Conditions: Postoperative Pain Relief
Interventions: DRUG: Placebo|DRUG: transdermal therapeutic system- nicotine.|DRUG: transdermal therapeutic system- melatonin.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Anti-Viral Effects of Voclosporin in COVID-19 Positive Kidney Transplant Recipients
Status: UNKNOWN
Conditions: Covid19|Kidney Transplant Infection
Interventions: DRUG: Voclosporin|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Following Repeat-Dose of Evinacumab (Anti-ANGPTL3) in Patients With Severe Hypertriglyceridemia (sHTG) at Risk for Acute Pancreatitis
Status: COMPLETED
Conditions: Severe Hypertriglyceridemia (sHTG)
Interventions: DRUG: evinacumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Association Study Between VDR Gene Polymorphisms and Risk and Features of MG in Han Chinese Population
Status: COMPLETED
Conditions: Myasthenia Gravis, Ocular|Gene Polymorphism
Interventions: GENETIC: Genotype analysis for VDR rs1544410, rs2228570, rs731236, and rs7975232 polymorphisms
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bypass Surgery Versus Everolimus-Eluting Stent Implantation for Multivessel Coronary Artery Disease (BEST)
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: DEVICE: everolimus-eluting stent|PROCEDURE: coronary artery bypass graft surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: L-TIL Plus Tislelizumab for PD1 Antibody Resistant aNSCLC
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: COMBINATION_PRODUCT: L-TIL, Tislelizumab, Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of D745 Added to D150 Plus D759 Therapy in Patients With Type 2 Diabetes
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: D745 formulation I|DRUG: D745 formulation II|DRUG: D745 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transversus Abdominis Plane Block During Kidney Transplant Surgery
Status: COMPLETED
Conditions: Kidney Transplant
Interventions: DRUG: Ropivacaine 500mg/100ml Naropeine|DRUG: 0.9% sodium chloride BAXTER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: Far-IR Emitted by Compression Stockings for Cellulitis Treatment
Status: UNKNOWN
Conditions: Cellulitis|Quality of Life
Interventions: OTHER: Far-IR compression stockings|OTHER: No far-IR compression stockings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FREQUENCY OF FIBROMYALGIA IN PATIENTS WITH CELIAC DISEASE
Status: RECRUITING
Conditions: Celiac Disease|Fibromyalgia
Interventions: DIAGNOSTIC_TEST: Pain location inventory (PLI)|DIAGNOSTIC_TEST: Symptom Impact Questionnaire (SIQR)|DIAGNOSTIC_TEST: Fibromyalgia Impact Questionnaire (FIQ)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Metformin Reduce the Relapse Rate on Patients With B-cell Precursor (Ph+ Negative) Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fosfomycin Versus Standard of Care in Children With Antibiotic-resistant Urinary Tract Infections
Status: RECRUITING
Conditions: Urinary Tract Infections
Interventions: DRUG: Fosfomycin|DRUG: Standard of care antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Chronic Incretin-based Therapy in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis|Pancreatic Insufficiency
Interventions: DRUG: Sitagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Vitamin D Supplementation in Vitamin D Deficient Obese Children During Weight-loss Program
Status: UNKNOWN
Conditions: Obesity
Interventions: DRUG: Vitamin D 1200 IU|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of NK Cells in the Treatment of Severe Endometriosis
Status: UNKNOWN
Conditions: NK Cell Mediated Immunity|Endometriosis
Interventions: BIOLOGICAL: Autologous NK cell therapy|DRUG: GnRHa combained with reverse addition therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Talazoparib in Relapsed Ovarian, Fallopian Tube, and Peritoneal Cancer
Status: WITHDRAWN
Conditions: Ovarian Cancer
Interventions: DRUG: Talazoparib|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Combination Therapy With PEGASYS (Pegylated Interferon Alfa-2a (40KD)) and Copegus (Ribavirin) in Patients With Chronic Hepatitis C Genotype 2 or 3 Who Do Not Achieve a Rapid Viral Response
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: peginterferon alfa-2a|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of the Akura Thrombectomy System in the Treatment of Acute Pulmonary Embolism
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Embolism Acute
Interventions: DEVICE: ATC System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of HPN424 in Patients With Advanced Prostate Cancer
Status: TERMINATED
Conditions: Advanced Prostate Cancer
Interventions: BIOLOGICAL: HPN424 Fixed IV 1.3 to 150 ng/kg|BIOLOGICAL: HPN424 Prime Step IV 36 ng/kg Target|BIOLOGICAL: HPN424 1 Prime Step IV 225-300 ng/kg Target|BIOLOGICAL: HPN424 2 Prime Step IV 300 ng/kg Target|BIOLOGICAL: HPN424 2 Prime Step IV 450 ng/kg Target|BIOLOGICAL: HPN424 Fixed SC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Chronic Myeloid Leukemia Treatment Landscape and Real-life Treatment Outcomes in Hungary: Analysis of National Health Insurance Fund Database
Status: COMPLETED
Conditions: Chronic Myeloid Leukaemia
Interventions: DRUG: Bosutinib|DRUG: Imatinib|DRUG: Nilotinib|DRUG: Dasatinib|DRUG: Ponatinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study on MK-3475 Plus Chemotherapy Versus Chemotherapy Alone in Recurrent, Platinum-resistant Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Gemcitabine|DRUG: Paclitaxel|DRUG: Liposomal Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Position Sense, Balance, and Dual Task Performance at the Menstrual Cycle in Females With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Neurologic Symptoms|Menstrual Cycle
Interventions: OTHER: Position Sense|OTHER: Balance|OTHER: Dual Task Performance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of Adverse Events in a Naive Pediatric Population Treated With an Antipsychotic
Status: COMPLETED
Conditions: Dissociative Disorders|Schizophrenia
Interventions: OTHER: Rispéridone, aripiprazole, olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of the QT/QTc Interval Between an Outpatient HIV-Infected Population on Antiretroviral Therapy and Two Large HIV-Negative Cohorts
Status: COMPLETED
Conditions: QT and Corrected QT Intervals Prolongation in HIV Positive Subjects Treated With an Antiretroviral Regimen
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Effect of Lansoprazole on Hospitalized Neonates With Gastroesophageal Reflux Disease
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: Lansoprazole|DRUG: Lansoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Safety Study of the Endologix Fenestrated Stent Graft System
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: DEVICE: Endovascular Aortic Aneurysm Repair (Endologix Fenestrated Stent Graft System)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Safety and Immunogenicity Trial of UBI Microparticulate Monovalent (HIV-1 MN) Branched Peptide Vaccine in HIV-1 Seronegative Human Subjects
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: HIV-1 Peptide Vaccine, Microparticulate Monovalent|BIOLOGICAL: rgp120/HIV-1MN Monovalent Octameric V3 Peptide Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer
Status: RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Estrogen Receptor Positive|HER2/Neu Negative|Progesterone Receptor Positive|Prognostic Stage IV Breast Cancer AJCC v8|Elevated CA15-3 or CEA or CA27-29
Interventions: OTHER: Usual care disease monitoring|OTHER: Serum Tumor Marker directed disease monitoring|OTHER: Quality-of-Life Assessment|OTHER: Anxiety Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Short Versus Long Protocol for IVF and IVF+ICSI
Status: COMPLETED
Conditions: Infertility|Ovarian Hyperstimulation Syndrome|Quality of Life|Live Birth
Interventions: DRUG: Patients receiving short protocol IVF/ICSI-treatment.|DRUG: Long protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of a ZT-1 Implant in Patients Suffering From Alzheimer's Disease
Status: COMPLETED
Conditions: Moderate Alzheimer's Disease
Interventions: DRUG: ZT-1|DRUG: Donepezil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Plus Cisplatin in Treating Patients With Ovarian Epithelial Cancer or Primary Peritoneal Cancer That Is Recurrent or Has Not Responded to Platinum-based Chemotherapy
Status: COMPLETED
Conditions: Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: cisplatin|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Anlotinib Combined With Pemetrexed And Carboplatin as First-line Treatment in Advanced Nonsquamous NSCLC
Status: UNKNOWN
Conditions: Non-squamous Cell Non-Small Cell Lung Cancer
Interventions: DRUG: Anlotinib Combined With Pemetrexed And Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arthroplasty Versus Fusion in Anterior Cervical Surgery: Prospective Study of the Impact on the Adjacent Level
Status: COMPLETED
Conditions: Clinical Radiculopathy|Myelopathy Due to a Cervical Disk Disease
Interventions: DEVICE: cervical disc prosthesis with a mobile insert named Mobi-C|PROCEDURE: arthrodesis - cervical disk surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KOmparison Study KOmparison Study
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Krill oil or Fish oil|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Continuous Subcutaneous Hydrocortisone Infusion in Congenital Adrenal Hyperplasia
Status: UNKNOWN
Conditions: Adrenal Hyperplasia, Congenital
Interventions: DRUG: Hydrocortisone|DRUG: Cortisone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cangpo Liujun Prescription on Cancer-related Fatigue in Advanced Colorectal Cancer With Spleen Deficiency and Dampness Excess
Status: RECRUITING
Conditions: Cancer-Related Fatigue|Colorectal Cancer
Interventions: DRUG: Cangpo Liujun Prescription
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: T30 for Astigmatism in Digital Device Users
Status: ACTIVE_NOT_RECRUITING
Conditions: Contact Lens Complication|Astigmatism|Refractive Errors
Interventions: DEVICE: Total30 for Astigmatism Contact Lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of a Cognitive-Motor Fall Prevention Program on Fall Risk Factors
Status: RECRUITING
Conditions: Accidental Falls|Aging|Mild Cognitive Impairment
Interventions: BEHAVIORAL: Cognitive-motor Physical Activity|BEHAVIORAL: Multifactorial Physical Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Zinc Sulfate Acceptability
Status: COMPLETED
Conditions: Acute Diarrhea
Interventions: DRUG: Zinc Sulfate Dispersible Tablet 20 mg (Elemental Zinc 20 mg as Zinc Sulfate Monohydrate / Tablet)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility of Surgery After Conversion Therapy for Locally Advanced and Advanced NSCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Neoplasm|Advanced Cancer|Locally Advanced Cancer
Interventions: PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive-behavioral Therapy vs. Nutrition Counseling for Avoidant/Restrictive Food Intake Disorder
Status: RECRUITING
Conditions: Avoidant/Restrictive Food Intake Disorder (ARFID)
Interventions: BEHAVIORAL: Cognitive-Behavioral Therapy for Avoidant/Restrictive Food Intake Disorder (CBT-AR)|BEHAVIORAL: Nutrition Counseling for Avoidant/Restrictive Food Intake Disorder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antigen-specific T Cell Therapy for AML or MDS Patients With Relapsed Disease After Allo-HCT
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome (MDS)
Interventions: BIOLOGICAL: Infusion of NEXI-001 T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hybrid Robot+FES Stroke Rehablitation
Status: RECRUITING
Conditions: Stroke
Interventions: COMBINATION_PRODUCT: Ankle robot training group|COMBINATION_PRODUCT: Ankle robot training and functional electrical stimulation(FES) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Treatment of Actinic Keratoses With Different Light Doses
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DEVICE: Photodynamic therapy with light dose of 70 J/cm2 using a broad-band red light source|PROCEDURE: Photodynamic therapy with 100J/cm2 light dose using a broad-band red light source
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of TLL018 in Patients With Plaque Psoriasis
Status: COMPLETED
Conditions: Moderate to Severe Plaque Psoriasis
Interventions: DRUG: TLL018 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Impact of Group Participation on Adults With Aphasia
Status: ACTIVE_NOT_RECRUITING
Conditions: Aphasia, Acquired|Stroke|Rehabilitation|Language Disorder, Acquired
Interventions: BEHAVIORAL: Language intervention with group sessions and independent tasks with emphasis on improving reading and writing skills among persons with aphasia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antiplatelet Therapy for Patients Undergoing Transcatheter Aortic Valve Implantation
Status: COMPLETED
Conditions: Aortic Valve Disease|Myocardial Infarction|Stroke|Bleeding
Interventions: DRUG: Aspirin + clopidogrel|DRUG: Aspirin monotherapy|DRUG: OAC + clopicogrel|DRUG: OAC monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Exploring the Mechanism of Plaque Rupture in Acute Coronary Syndrome Using Coronary CT Angiography and Computational Fluid Dynamics II (EMERALD II) Study
Status: UNKNOWN
Conditions: Acute Myocardial Infarction|Unstable Angina
Interventions: DIAGNOSTIC_TEST: Coronary CT angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Accuracy of Community General Pediatrician Diagnosis of Autism Compared to a Multidisciplinary Team Assessment
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DIAGNOSTIC_TEST: General pediatrician autism diagnostic assessment|DIAGNOSTIC_TEST: Multidisciplinary team diagnostic assessment|DIAGNOSTIC_TEST: Autism Assessment for Preschoolers with Language Element Sequence
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Virtual Reality Based Mirror Therapy
Status: RECRUITING
Conditions: Stroke|Upper Extremity Paresis|Upper Extremity Paralysis
Interventions: OTHER: Virtual reality applications based on mirror therapy|OTHER: Conventional treatment|OTHER: Mirror therapy|OTHER: Placebo virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CSP #2025 - Geriatric OUt-of-hospital Randomized MEal Trial in Heart Failure: Veterans Affairs (GOURMET-VA)
Status: NOT_YET_RECRUITING
Conditions: Heart Failure
Interventions: OTHER: Home-delivered meals and short-term dietary counseling|OTHER: Study -defined standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate a Single Dose of LTX-109 in Subjects With COVID-19 (Coronavirus Disease 2019) Infection.
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: LTX-109 gel, 3%|DRUG: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of Serum Creatinine Dosage and Renal Clearance
Status: COMPLETED
Conditions: Kidney Failure
Interventions: PROCEDURE: Calculation of inuline clearance|PROCEDURE: Measuring serum creatinine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Gemcitabine and Irinotecan in Treating Patients With Locally Advanced or Metastatic Bladder Cancer
Status: TERMINATED
Conditions: Bladder Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficiency of Robotic Hand Exoskeleton System in Stroke Patients
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Conventional physiotherapy|OTHER: Robotic Hand Exoskeleton System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-label Extension of Study 20130173 of Denosumab in Children and Young Adults With Osteogenesis Imperfecta
Status: TERMINATED
Conditions: Osteogenesis Imperfecta (OI)
Interventions: DRUG: Denosumab|DRUG: Alternative osteoporosis medications
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of NPX887 for Participants With Solid Tumors Known to Express B7-H7/HHLA2
Status: RECRUITING
Conditions: Metastatic Malignant Neoplasm
Interventions: DRUG: NPX887
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Effects of Meal Frequency and Protein Load on Cardiometabolic Risk Factors
Status: COMPLETED
Conditions: Metabolic Disease|Cardiovascular Disease
Interventions: OTHER: Meal (Eating) Frequency|OTHER: Protein Composition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Platelet Rich Plasma Injection Into Ovary of Patients With Premature Ovarian Insufficiency
Status: COMPLETED
Conditions: Premature Ovarian Failure
Interventions: PROCEDURE: PRP injection inside the ovary by laparoscoy. The injection volume is 2 ml
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Once-Daily NNC0090-2746 in Participants With Type 2 Diabetes Inadequately Controlled With Metformin
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus Type 2
Interventions: DRUG: Liraglutide|DRUG: Metformin|DRUG: Placebo|DRUG: NNC0090-2746
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Therapy Targeting Depression and HIV Treatment Adherence (The TRIAD Study)
Status: COMPLETED
Conditions: HIV|Depression|HIV Infections
Interventions: BEHAVIORAL: Cognitive behavioral therapy (CBT) for adherence and depression (CBT-AD)|BEHAVIORAL: Life-steps adherence treatment|BEHAVIORAL: Information and supportive psychotherapy (ISP) for adherence and depression (ISP-AD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: S0350 Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Peripheral T-Cell Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: cisplatin|DRUG: etoposide|DRUG: gemcitabine|DRUG: methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Lapatinib (GW572016) And Letrozole Versus Letrozole In Subjects With Advanced Or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Lapatinib|DRUG: Letrozole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase l Study to Evaluate the Pharmacokinetics and Safety Pasireotide in Subjects With Varying Degrees of Renal Impairment Compared to Healthy Volunteers
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: SOM230
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Standard Cut Rate 27-Gauge System Versus Ultrahigh-Speed 27-Gauge System in Macular Surgery
Status: UNKNOWN
Conditions: Macular Disease
Interventions: DEVICE: Ultrahigh-speed cut rate 27-gauge system|DEVICE: Standard cut rate 27-gauge system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cholecalciferol Supplementation Effect on Parathyroid Hormone in Hemodialysis Patients
Status: COMPLETED
Conditions: Vitamin D Deficiency|Hemodialysis Patient
Interventions: DRUG: cholecalciferol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Feasibility and Safety Study of Concomitant Therapy With Allo-CAR-T Cells and Allo-HSCT in Patients With Relapse or Refractory Leukemia
Status: UNKNOWN
Conditions: B Cell Leukemia
Interventions: BIOLOGICAL: donor-derived CD19/22 bispecific CAR-T cells or CD19-directed CAR-T cells; donor-derived-HSCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib With Gemcitabine/Doxorubicin in Patients With Urothelial Cancer and Other Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor|Urethral Cancer
Interventions: DRUG: Bortezomib|DRUG: Gemcitabine|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Inflammatory Biomarkers When Symptomatic Contact Lens Wearers Are Refit in Acuvue Oasys 1-Day Lenses
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: Acuvue® Oasys 1-Day
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effect of Intravenous Lidocaine on Immediate Post-operative Pain, Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Placebo Controlled Trial
Status: UNKNOWN
Conditions: Post-operative Pain|Post-operative Nausea and Vomiting
Interventions: DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: ECOSPOR III - SER-109 Versus Placebo in the Treatment of Adults With Recurrent Clostridium Difficile Infection
Status: COMPLETED
Conditions: Clostridium Difficile Infection
Interventions: BIOLOGICAL: SER-109|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy & Safety of SCH 900435 in Schizophrenia (Study P06079)(WITHDRAWN)
Status: WITHDRAWN
Conditions: Schizophrenia
Interventions: DRUG: SCH 900435 (Org 25935)|DRUG: Placebo|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Find Out How Multiple Doses of BIIB091 Affect the Electrical Activity of the Heart in Healthy Participants
Status: NOT_YET_RECRUITING
Conditions: Healthy Volunteer
Interventions: DRUG: BIIB091|DRUG: Moxifloxacin|DRUG: BIIB091-matched Placebo|DRUG: Moxifloxacin-matched Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Single Oral Dose of Moxidectin on the Cardiac QT Interval of Healthy Volunteers
Status: COMPLETED
Conditions: QT Effects in Healthy Volunteers
Interventions: DRUG: Moxidectin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Two Period / Two Treatment Cross-over to Assess the Effect of Florastor® on Gastrointestinal Tolerability, Safety, and PK in Healthy Subjects Receiving Zavesca®
Status: COMPLETED
Conditions: Diarrhea
Interventions: DRUG: Treatment A|DRUG: Treatment B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Shockwave Coronary Rx Lithoplasty® Study (Disrupt CAD I)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Shockwave Coronary Rx Lithoplasty® System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutrition Recommendation Intervention trialS in Children's Healthcare
Status: NOT_YET_RECRUITING
Conditions: Obesity, Childhood|Nutrition|Health Risk Behaviors|Breastfeeding|Exclusive Breastfeeding|Diabetes
Interventions: OTHER: Childcare Navigator|OTHER: Lactation Consultant|OTHER: Lactation Consultant Support and Childcare Navigator Support|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Atherosclerotic Cardiovascular Disease
Interventions: DRUG: Inclisiran sodium 300 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )
Status: RECRUITING
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: DRUG: IVA337|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT