pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Norepinephrine Addition in Spinal Anesthesia of Caesarean Section
Status: RECRUITING
Conditions: Hypotension Drug-Induced
Interventions: DRUG: Norepinephrine Bolus|DRUG: Norepinephrine infusion|DRUG: Normal Saline Flush, 0.9% Injectable Solution|DRUG: Normal Saline 0.9% Infusion Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I Study to Assess the Tolerability and Efficacy of Nivolumab in Patients With Hematologic Malignancies
Status: TERMINATED
Conditions: Hematologic Malignancies
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antibiotic Prophylaxis for Simple Hand Lacerations
Status: TERMINATED
Conditions: Simple Hand Lacerations
Interventions: DRUG: cephalexin|DRUG: clindamycin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing Obstetric Complications With Dietary Intervention
Status: NOT_YET_RECRUITING
Conditions: Gestational Diabetes|Gestational Hypertension|High Risk Pregnancy|Preeclampsia
Interventions: BEHAVIORAL: Maternal Health Management Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Optimal Duration of Oxaliplatin in Adjuvant XELOX for Gastric Cancer Patients (EXODOX)
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Oxaliplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Risk Enabled Therapy After Neoadjuvant Immunochemotherapy for Bladder Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Muscle-Invasive Bladder Carcinoma
Interventions: DRUG: AMVAC + Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of EDUcation and EXercise Compared to Education Alone on Clinical and Physiological Outcomes in Patients With Hip Osteoarthritis
Status: RECRUITING
Conditions: Hip Osteoarthritis
Interventions: OTHER: PRT|OTHER: EDU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Collaborative Urological Prosthetics Investigation Directive Research Group
Status: ACTIVE_NOT_RECRUITING
Conditions: Erectile Dysfunction|Penile Prosthesis Infection
Interventions: DRUG: Doxycycline|DRUG: Ciprofloxacin|DRUG: Augmentin|DRUG: Bactrim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Adult
Interventions: BIOLOGICAL: Human Mesenchymal Stromal Cells|BIOLOGICAL: Cell Reconstitution Media
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Effect of Repeated Administration of G-CSF on Hot Flashes in Postmenopausal Women
Status: COMPLETED
Conditions: Postmenopausal Symptoms
Interventions: BIOLOGICAL: G-CSF|OTHER: Placebo/Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: S0429: Docetaxel, Cetuximab, and Radiation Therapy in Treating Patients With Stage III Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: docetaxel|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of S-600918 in Adults With Refractory Chronic Cough
Status: COMPLETED
Conditions: Chronic Cough
Interventions: DRUG: S-600918|DRUG: Placebo to S-600918
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab vs Placebo With Stereotactic Body Radiation Therapy in Early Stage Unresected Non-small Cell Lung Cancer (NSCLC) Patients / Osimertinib Following SBRT in Patients With Early Stage Unresected NSCLC Harboring an EGFR Mutation
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Durvalumab|OTHER: Placebo|DRUG: Osimertinib (single-arm, open-label)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing New Formats for the Presentation of Research Evidence to Health Care Managers and Policy Makers
Status: COMPLETED
Conditions: Uptake of Systematic Review Evidence
Interventions: OTHER: Novel systematic review format
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Omentin-1 Level in Psoriatic Patients Treated With Narrowband Ultraviolet B Phototherapy Versus Acitretin
Status: COMPLETED
Conditions: Psoriasis
Interventions: RADIATION: Narrowband Ultraviolet B|DRUG: Acitretin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sirolimus-eluting vs Zotarolimus-eluting Stents for Chronic Total Coronary Occlusions
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Disease|Coronary Stenosis
Interventions: DEVICE: sirolimus-eluting stent, zotarolimus-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Rituximab and Autologous Effector Lymphocytes in Non-Hodgkin Follicular Lymphoma in Response to First Line Chemotherapy
Status: UNKNOWN
Conditions: Follicular Lymphoma|Follicular Non-Hodgkin´s Lymphoma|Autologous Effector Lymphocytes
Interventions: BIOLOGICAL: Autologous effector lymphocytes expanded ex-vivo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Speech Entrainment for Aphasia Recovery
Status: ACTIVE_NOT_RECRUITING
Conditions: Aphasia|Aphasia Non Fluent|Stroke
Interventions: BEHAVIORAL: SET (Speech Entrainment Therapy) 3 weeks|BEHAVIORAL: SET (Speech Entrainment Therapy) 4.5 weeks|BEHAVIORAL: SET (Speech Entrainment Therapy) 6 weeks|OTHER: No Therapy 6 Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hormone Therapy Plus Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: bicalutamide|DRUG: estramustine phosphate sodium|DRUG: etoposide|DRUG: flutamide|DRUG: paclitaxel|DRUG: Luteinizing hormone releasing hormone [LHRH] agonist|RADIATION: Radiation therapy|DRUG: warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare the Immune Response & Safety Elicited by Henogen's Adjuvanted Hepatitis B Vaccine vs Aventis Pasteur MSD's Hepatitis B Vaccine in Pre-Dialysis & Dialysis Patients Who Did Not Respond to Previous Hepatitis B Vaccination
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: HB-AS02V|BIOLOGICAL: HBVAXPRO vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Regorafenib as Single Agent in Patients With Metastatic Colorectal Cancer (mCRC) With Any RAS or BRAF Mutation Previously Treated With FOLFOXIRI Plus Bevacizumab
Status: TERMINATED
Conditions: Colorectal Neoplasms|Metastatic Disease
Interventions: DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vorinostat, Bortezomib, and Doxorubicin Hydrochloride Liposome in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: bortezomib|DRUG: pegylated liposomal doxorubicin hydrochloride|DRUG: vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Oxaliplatin in Combination With 5-Fu in 1st Line Treatment of Locally Advanced or Metastatic Squamous Cell Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: Oxaliplatin, 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Mesenchymal Stem Cells in Primary Knee Osteoarthritis
Status: RECRUITING
Conditions: Osteoarthritis Knee
Interventions: BIOLOGICAL: Autologous Adipose Tissue-Derived Mesenchymal Stem Cell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: iCARE 2.0: A Pilot Intervention of Dialectical Behavioural Therapy for Youth With Type 2 Diabetes.
Status: RECRUITING
Conditions: Diabetes Mellitus Type 2, Childhood-Onset
Interventions: BEHAVIORAL: Dialectical Behavioural Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of a 6-Month Sustained-Release Formulation of Leuprolide Acetate in Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: Leuprolide acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Bone Marrow MNC for the Treatment of Cerebral Palsy in Subjects Below 15 Years
Status: UNKNOWN
Conditions: Cerebral Palsy
Interventions: OTHER: Intra thecal inj of autologous MNC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Antiretroviral Adherence and Quality-of-life Support for HIV+ Patients in India With Twice-daily Interactive Voice Response (IVR) Calls With Health and Mental Health Messaging Compared to Weekly IVR Survey Only Control Condition: The Mobile-messaging Adherence and Support for Health Study, India.
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: BEHAVIORAL: Daily IVR Calls Intervention|BEHAVIORAL: Weekly IVR Survey Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Individualized Automatic Target Coaching Message for Glycemic Management and Depressive Symptom
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 1
Interventions: BEHAVIORAL: Personalized coaching messages for blood glucose and emotions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diabetes-Specific Formula in Individuals With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Diabetes-Specific Formula|OTHER: Bread with Spread|OTHER: Rice Porridge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Handgrip Training With and Without Blood Flow Restriction in Relation to Gender Among Healthy Young Adults
Status: COMPLETED
Conditions: Sports Physical Therapy
Interventions: OTHER: Handgrip strength training without Blood flow restriction|OTHER: Handgrip strength training with Blood flow restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Utility of an Age, Sex, and Gene Expression Score (ASGES or Corus CAD) in African American Patients.
Status: COMPLETED
Conditions: Coronary Artery Disease|Angina Pectoris|Chest Pain|Cardiovascular Diseases|Coronary Heart Disease|CHD|CVD|CAD
Interventions: DIAGNOSTIC_TEST: Corus CAD (ASGES)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Characterization of the Effects of Prolonged-release Fampridine on Ambulatory Function in Patients With Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: DRUG: Prolonged-release Fampridine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation|Inflammation
Interventions: DEVICE: Parasym device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sellick Interest in Rapid Sequence Induction
Status: COMPLETED
Conditions: Rapid Sequence Induction of General Anesthesia|Sellick Maneuver|Acid Aspiration Syndrome|Lung Aspiration|Aspiration Pneumonia
Interventions: OTHER: effective sellick maneuver|OTHER: sham sellick maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Drug Interaction Study of Azithromycin and Theophylline
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Asthma
Interventions: DRUG: Theophylline with azithromycin|DRUG: Theophylline alone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Human Amniotic Epithelial Cells for Asherman's Syndrome
Status: UNKNOWN
Conditions: Asherman's Syndrome
Interventions: BIOLOGICAL: hAECs|BIOLOGICAL: biological amnion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Second-line Treatment With Icotinib in Esophageal Carcinoma Patients With EGFR Overexpression (IHC 3+) or Positive FISH
Status: COMPLETED
Conditions: Adenocarcinoma of the Gastroesophageal Junction|Esophageal Carcinoma
Interventions: DRUG: Icotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erlotinib Combined With Chemotherapy in TKI Resistant Non-Small Cell Lung Cancers
Status: RECRUITING
Conditions: Carcinoma, Non-Small Cell Lung|EGFR Gene Mutation
Interventions: DRUG: Gemcitabine platinum combined with erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early vs. Late Time Restricted Eating in Adolescents With Obesity at Risk for Diabetes
Status: RECRUITING
Conditions: Pediatric Obesity|Time Restricted Feeding|Time Restricted Eating
Interventions: BEHAVIORAL: Early Time Restricted Eating|BEHAVIORAL: Late Time Restricted Eating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Inhalational Anaesthetics in Cognitive Functions in Down Syndrome Patients
Status: COMPLETED
Conditions: Down Syndrome
Interventions: DRUG: Sevoflurane|DRUG: Desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Temozolomide Plus Bevacizumab in Patients With Metastatic Melanoma Involving the Central Nervous System
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Temozolomide|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efineptakin Alfa and Pembrolizumab for the Treatment of Recurrent Glioblastoma
Status: RECRUITING
Conditions: High Grade Astrocytic Tumor|Recurrent Glioblastoma, IDH-Wildtype|Recurrent Gliosarcoma
Interventions: PROCEDURE: Biospecimen Collection|BIOLOGICAL: Efineptakin alfa|BIOLOGICAL: Pembrolizumab|PROCEDURE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Human Endostatin Combined With Envafolimab and Synchronal Radiochemotherapy
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Squamous Non-small Cell Lung Cancer
Interventions: DRUG: Recombinant Human Endostatin Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Buspirone as a Potential Treatment for Recurrent Central Apnea
Status: TERMINATED
Conditions: Central Apnea|Heart Failure
Interventions: DRUG: Acetazolamide|DRUG: Buspirone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Subcutaneous Administration of the Fixed-Dose Combination of Pertuzumab and Trastuzumab in Combination With Chemotherapy in Participants With HER2-Positive Early Breast Cancer
Status: COMPLETED
Conditions: Early Breast Cancer
Interventions: DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Docetaxel|DRUG: Paclitaxel|DRUG: Pertuzumab IV|DRUG: FDC of Pertuzumab and Trastuzumab SC|DRUG: Trastuzumab IV|DRUG: Trastuzumab SC|PROCEDURE: Surgery|RADIATION: Post-operative Radiotherapy|DRUG: Hormone Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced-Intensity Regimen Before Allogeneic Transplant for Patients With Relapsed Non-Hodgkin's or Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Lymphoma
Interventions: PROCEDURE: Extracorporeal Photopheresis|DRUG: Pentostatin|RADIATION: Total body irradiation (TBI)|PROCEDURE: Allogeneic bone marrow transplantation|DRUG: Cyclosporin (CSA)|DRUG: Mycophenolate mofetil (MMF)|DRUG: Methotrexate (MTX)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of 3 Dose Levels of NMD670 in Adult Patients With Myasthenia Gravis
Status: RECRUITING
Conditions: Myasthenia Gravis|Myasthenia Gravis, MuSK
Interventions: DRUG: NMD670|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electrical Stimulation for the Treatment of Post-Amputation Pain Using the SPRINT System
Status: COMPLETED
Conditions: Post-Amputation Pain|Phantom Limb Pain|Residual Limb Pain
Interventions: DEVICE: SPRINT Peripheral Nerve Stimulation (PNS) System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Analgesia After Cesarean Section; Comparison Among Ultrasound Guided Erector Spinae, Quadratus Lumborum or Transversus Abdominis Plane Blocks
Status: RECRUITING
Conditions: Postoperative Analgesia|Cesarean Section|Erector Spinae Block|Quadratus Lumborum Block|Transversus Abdominis Plane Block
Interventions: OTHER: Erector spinae plane block (20 ml bupivacaine 0.25% in each side)|OTHER: Posterior Quadratus lumborum plane block (20 ml bupivacaine 0.25% in each side)|OTHER: Lateral Transversus abdominis plane block (20 ml bupivacaine 0.25% in each side)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: New Antibiotic to Treat Pediatric Patients With Infections Due to a Specific Bacteria (Vancomycin-Resistant Enterococcus)
Status: COMPLETED
Conditions: Bacterial Infections
Interventions: DRUG: Zyvox® / Linezolid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contingency Management for Drug Use: Does Age Matter?
Status: RECRUITING
Conditions: Opioid Use Disorder|Methamphetamine Abuse|Cocaine Use Disorder
Interventions: BEHAVIORAL: DynamiCare app (app-based contingency management)|BEHAVIORAL: Sham control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Use of Fulvestrant and Binimetinib Targeted Treatment for NF1 Mutation in Hormone Receptor-Positive Metastatic Breast Cancer (A ComboMATCH Treatment Trial)
Status: RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Metastatic HER2-Negative Breast Carcinoma|Metastatic Hormone Receptor-Positive Breast Carcinoma
Interventions: DRUG: Binimetinib|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|PROCEDURE: Echocardiography|DRUG: Fulvestrant|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Multigated Acquisition Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Acupuncture Against Nausea in Children
Status: UNKNOWN
Conditions: Nausea|Vomiting|Cancer
Interventions: PROCEDURE: laser acupuncture|PROCEDURE: placebo laser acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study That Will Compare the Effect of Two Drugs on Participants With Low Bone Mass and a Recent Hip Fracture
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Teriparatide|DRUG: Risedronate|DRUG: Placebo|DIETARY_SUPPLEMENT: Calcium|DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Apixaban Reversal by Ciraparantag as Measured by WBCT
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ciraparantag|DRUG: Placebo|DRUG: Apixaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Arterial Spin Labeling MRI Focal Abnormalities in Refractory Epilepsy
Status: COMPLETED
Conditions: Focal Epilepsy
Interventions: DEVICE: Arterial Spin Labeled (ASL) MRI sequence
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Visual Outcomes With a Trifocal IOL in Subjects With Open-angle Glaucoma
Status: COMPLETED
Conditions: Cataract|IOL|Glaucoma, Open-Angle
Interventions: PROCEDURE: Cataract surgery with implantation of trifocal IOL combined with trabecular scaffold
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TRansfusion Strategies in Acute Brain INjured Patients
Status: COMPLETED
Conditions: Acute Brain Injury|Blood Transfusion
Interventions: PROCEDURE: Restrictive Transfusion Strategy|PROCEDURE: Liberal Transfusion Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Safety and Effectiveness of Octenidine Dihydrochloride
Status: COMPLETED
Conditions: Preoperative Skin Preparation
Interventions: DRUG: Chlorhexidine gluconate|DRUG: N,N'-(1,10-decanediyldi-1(4H)-Pyridinyl-4-ylidene)-Bis-(1-octanamine) Dihydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Lymphocyte Count, ATG Dose and Incidence and Severity of GVHD in Pediatric Recipients of HSCT
Status: COMPLETED
Conditions: Hematopoietic Stem Cell Transplantation
Interventions: OTHER: Lower lymphocyte/ATG ratio|OTHER: Higher lymphocyte/ATG ratio
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: OSI-774 and Bevacizumab in the Treatment of Patients With Metastatic Renal Cell Carcinoma
Status: COMPLETED
Conditions: Kidney Cancer
Interventions: DRUG: OSI-774|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Double Y-shaped Plates and Lag Screws in Fixation of Anterior Mandibular Fractures
Status: COMPLETED
Conditions: Mandibular Fractures
Interventions: DEVICE: Lag Screws|DEVICE: double Y-shaped plates
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficiency of Two Dimensional High Definition vs Three Dimensional Endoscopic Systems in Transanal Endoscopic Surgery
Status: COMPLETED
Conditions: Rectal Adenoma
Interventions: PROCEDURE: 2-D high definition vision systems, transanal endoscopic operation (TEO)|PROCEDURE: Transanal endoscopic microsurgery (TEM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy and Cost-effectiveness of Racecadotril in Children With Acute Diarrhea in Mexico
Status: COMPLETED
Conditions: Diarrhea
Interventions: DRUG: Racecadotril|DRUG: Placebo groups
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risk Stratification of Hepatocarcinogenesis Using a Deep Learning Based Clinical, Biological and Ultrasound Model in High-risk Patients
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Chronic Liver Disease
Interventions: OTHER: Video acquisition
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sustainable Solutions for Paediatric Basic Life Support Training in Day Care Centres
Status: COMPLETED
Conditions: Cardiopulmonary Resuscitation|Education|Medical Emergencies
Interventions: OTHER: Dyad training method|OTHER: Instructor led training method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Proprioception of Platelet Rich Plasma for Patients With Ankle Sprain
Status: RECRUITING
Conditions: Ankle Sprain 2Nd Degree|Ankle Sprain 3Rd Degree
Interventions: DRUG: PRP|OTHER: Rehabilitation|COMBINATION_PRODUCT: PRP+Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Evaluation of Tirofiban Using a Single High-Dose Bolus In Subjects With Varying Degrees of Renal Function
Status: COMPLETED
Conditions: Renal Insufficiency
Interventions: DRUG: Tirofiban
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breathing Exercises and Auricular Vagus Nerve Stimulation
Status: COMPLETED
Conditions: Breathing Exercises|Auricular Vagus Nerve Stimulation|Autonomic Nervous System
Interventions: DEVICE: Vagus nerve stimulation|BEHAVIORAL: Breathing exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Empowerment-Based Interventions on Self-Efficacy and Self-Care Capacity Among Adults With Sickle Cell Disease
Status: COMPLETED
Conditions: Self-Efficacy|Self-Care
Interventions: BEHAVIORAL: Empowerment-Based Interventions|BEHAVIORAL: Standard Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Persona Versus NexGen
Status: COMPLETED
Conditions: Osteoarthritis Arthritis|Joint Diseases|Musculoskeletal Diseases|Rheumatic Diseases
Interventions: DEVICE: Persona PS Knee Prosthesis by Zimmer|DEVICE: NexGen PS Knee Prosthesis by Zimmer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Ketone Supplement on Responses to Alcohol Challenge in Healthy Volunteers
Status: RECRUITING
Conditions: Alcohol Drinking
Interventions: DIETARY_SUPPLEMENT: Ketone Supplement|OTHER: Alcohol Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of 7-day and 14-day Bismuth Based Quadruple Therapy for Secondary Helicobacter Pylori Eradication
Status: COMPLETED
Conditions: Helicobacter Infection
Interventions: DRUG: pantoprazole|DRUG: bismuth|DRUG: metronidazole|DRUG: tetracycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HERMES STUDY: Study on the Feasibility and Efficiency of Noninvasive Positive-Pressure Ventilation (NPPV) in Prehospital Care
Status: WITHDRAWN
Conditions: ARF Secondary to COPD Exacerbation|ARF Secondary to Cardiogenic Acute Pulmonary Oedema
Interventions: DEVICE: Noninvasive Positive-Pressure Ventilation (NPPV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short and Long-term Results of Arterial Stiffness and Central Aortic Pressure After Kidney Transplantation
Status: COMPLETED
Conditions: Arterial Calcification|Aortic Stiffness|High Blood Pressure (& [Essential Hypertension])
Interventions: DEVICE: Device: Complior Analyse System|DEVICE: Tanita BC 418- Bioelectrical impedance analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Probiotics on Cardiometabolic Health
Status: COMPLETED
Conditions: Cardiometabolic Risk Factors
Interventions: DIETARY_SUPPLEMENT: Probiotics|DIETARY_SUPPLEMENT: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Post-Market Clinical Evaluation of the Treatment of Femur Fractures With the Femoral Nail PF
Status: RECRUITING
Conditions: Femoral Fracture
Interventions: DEVICE: Femoral Nail PF of the T2 Alpha Femur Antegrade GT/PF Nailing System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Checklist (Advanced Care Planning) for The Assessment of Mobility Needs in Patients With Sarcoma
Status: NOT_YET_RECRUITING
Conditions: Metastatic Sarcoma|Sarcoma
Interventions: BEHAVIORAL: Assessment|OTHER: Questionnaire Administration|OTHER: Interview|OTHER: Electronic Health Record Review
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Anti-reflux Control to Decrease Post Tonsillectomy Pain
Status: TERMINATED
Conditions: Laryngopharyngeal Reflux|Throat Pain
Interventions: DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hypovolemic Phlebotomy to Reduce Blood Transfusions in Major Hepatic Resections
Status: ACTIVE_NOT_RECRUITING
Conditions: Liver Neoplasms|Hepatectomy|Blood Transfusion|Blood Loss, Surgical
Interventions: PROCEDURE: Hypovolemic Phlebotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 3 Study to Evaluate the Safety and Tolerability of L606 in Subjects With PAH or PH-ILD
Status: RECRUITING
Conditions: Pulmonary Arterial Hypertension|Pulmonary Hypertension Due to Lung Diseases
Interventions: COMBINATION_PRODUCT: L606 inhalation suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myo-Inositol for Infertility in PCOS
Status: RECRUITING
Conditions: Polycystic Ovary Syndrome
Interventions: DIETARY_SUPPLEMENT: Inositol supplement|DIETARY_SUPPLEMENT: Placebo supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sacubitril/Valsartan in Left Ventricular Assist Device Recipients
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure
Interventions: DRUG: Sacubitril-Valsartan|DRUG: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Pyridoxine on Behavioral Adverse Events of Levetiracetam
Status: COMPLETED
Conditions: Epilepsy|Pyridoxine|Behavior Problem
Interventions: DRUG: Pyridoxine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study of a Rapid Immunization Schedule With FSME-IMMUN 0.5 mL in Healthy Adults Aged 16 - 65 Years
Status: COMPLETED
Conditions: Encephalitis, Tick-borne
Interventions: BIOLOGICAL: Tick-Borne Encephalitis (TBE) Vaccine (Inactivated)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Single-center, Feasibility Study to Evaluate the Use and Safety of the Percutaneous Ultrasound Gastrostomy Technique
Status: COMPLETED
Conditions: Gastrostomy
Interventions: DEVICE: Percutaneous Ultrasound Gastrostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial Of Bococizumab (PF-04950615; RN316) In Subjects With Hyperlipidemia Or Mixed Dyslipidemia At Risk Of Cardiovascular Events
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DRUG: Bococizumab (PF-04950615;RN316)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does a Low Volume Ultrasound-Guided Technique Reduce Common Complications of Interscalene Brachial Plexus Block?
Status: COMPLETED
Conditions: Pain After Shoulder Surgery
Interventions: DRUG: Variation in volume of local anesthetic|PROCEDURE: Ultrasound-guided interscalene brachial plexus block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Sleep and Circadian Treatments for Shift Workers
Status: COMPLETED
Conditions: Shift-Work Sleep Disorder|Shift-Work Related Sleep Disturbance
Interventions: BEHAVIORAL: 8-h Afternoon-Evening Sleep|BEHAVIORAL: 8-h Free Sleep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Intravascular High-pressure Cutting Balloon Catheters for PCI
Status: COMPLETED
Conditions: Patients With Atherosclerotic Plaques in the Coronary Arteries That Require Excision
Interventions: PROCEDURE: PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Optimize the Effects of Repetitive Transcranial Magnetic Stimulation on Neuropathic Pain
Status: COMPLETED
Conditions: Neuropathic Pain|Repetitive Transcranial Magnetic Stimulation
Interventions: DEVICE: Repetitive transcranial magnetic stimulation|DEVICE: Repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Furosemide in Early Acute Kidney Injury
Status: TERMINATED
Conditions: Acute Renal Failure
Interventions: DRUG: Furosemide|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn How Safe the Study Treatment BAY2395840 is, How it Affects the Body and How it Moves Into, Through, and Out of the Body if Given in Single and in Repetitive Doses to Japanese Healthy Male Participants
Status: COMPLETED
Conditions: Diabetic Neuropathic Pain|Healthy Volunteers
Interventions: DRUG: BAY2395840
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Hypofractionated External-beam RadiOtherapy for Intact Cervical Cancer (HEROICC-Trial): A Feasibility Study
Status: RECRUITING
Conditions: Cervical Cancer
Interventions: RADIATION: External beam radiotherapy (EBRT) + High-dose rate (HDR) Brachytherapy Experimental|RADIATION: External beam radiotherapy (EBRT) + High-dose rate (HDR) Brachytherapy Standard of Care|DRUG: Concurrent Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Pilot Study of Combined Immune Checkpoint Inhibition in Combination With Ablative Therapies in Subjects With Hepatocellular Carcinoma (HCC) or Biliary Tract Carcinomas (BTC)
Status: COMPLETED
Conditions: Biliary Tract Neoplasms|Liver Cancer|Hepatocellular Carcinoma|Cholangiocarcinoma|Bile Duct Cancer
Interventions: DRUG: Durvalumab|DRUG: Tremelimumab|PROCEDURE: Trans-arterial Catheter Chemoembolization (TACE)|PROCEDURE: Radiofrequency Ablation (RFA)|PROCEDURE: Cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Different Physiotherapy Programs on Functional Constipation
Status: COMPLETED
Conditions: Functional Constipation
Interventions: OTHER: connective tissue manipulation|OTHER: Interferential current stimulation (100 Hz frequency)|OTHER: Interferential current stimulation (0-100 Hz frequency)|OTHER: behavioural therapy|OTHER: exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Comparison of Rosuvastatin Versus Atorvastatin on Platelet Reactivity in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy With New P2Y12 Inhibitors (Trial gRANADa)
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: Atorvastatin|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of HMPL-653 in Treatment of Advanced Malignant Solid Tumors and TGCT
Status: RECRUITING
Conditions: Advanced Malignant Solid Tumors|TGCT
Interventions: DRUG: HMPL-653
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Test the Safety, Exposure, and Pharmacodynamic Markers of CSL311 in Patients With Mild-to-moderate Asthma and in Healthy Volunteers
Status: COMPLETED
Conditions: Asthma
Interventions: BIOLOGICAL: Human beta common receptor antagonist monoclonal antibody|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NAPLS Omega-3 Fatty Acid Versus Placebo Study
Status: COMPLETED
Conditions: Psychosis
Interventions: DRUG: Omega-3 Long Chain Fatty Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Developing Smokers for Smoker (S4S): A Collective Intelligence Tailoring System
Status: COMPLETED
Conditions: Tobacco Smoking
Interventions: BEHAVIORAL: Collective-Intelligence computer tailored health communication|BEHAVIORAL: Rule-based computer tailored health communication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Androgen Ablation Therapy With or Without Niraparib After Radiation Therapy for the Treatment of High-Risk Localized or Locally Advanced Prostate Cancer
Status: RECRUITING
Conditions: Prostate Carcinoma|Stage IIC Prostate Cancer AJCC v8|Stage III Prostate Cancer AJCC v8|Stage IIIA Prostate Cancer AJCC v8|Stage IIIB Prostate Cancer AJCC v8|Stage IIIC Prostate Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8
Interventions: DRUG: Abiraterone Acetate|DRUG: Antiandrogen Therapy|DRUG: Apalutamide|PROCEDURE: Biopsy|DRUG: Niraparib|DRUG: Prednisone|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advanced or Metastatic Pancreatic Cancer
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Pancreatic Adenocarcinoma|Metastatic Pancreatic Adenocarcinoma|Stage II Pancreatic Cancer AJCC v8|Stage III Pancreatic Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8|Unresectable Pancreatic Adenocarcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Endoscopic Ultrasound|DRUG: Fluorouracil|DRUG: Irinotecan|DRUG: Leucovorin|PROCEDURE: Lymph Node Biopsy|PROCEDURE: Magnetic Resonance Imaging|DRUG: Oxaliplatin|BIOLOGICAL: Pembrolizumab|DRUG: Photodynamic Therapy|PROCEDURE: Positron Emission Tomography|OTHER: Questionnaire Administration|DRUG: Verteporfin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Combination Therapy With Bojungikki-tang and Pembrolizumab Monotherapy in Patients With Advanced Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Bojungikki-tang(BJIKT)|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NEO-BLAST: Neoadjuvant Therapy for Bladder Cancer Followed by Active Surveillance vs Treatment
Status: NOT_YET_RECRUITING
Conditions: Muscle-Invasive Bladder Carcinoma
Interventions: PROCEDURE: Active Surveillance|PROCEDURE: Control arm - Definitive bladder treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Frequency, Clinical Phenotype and Genetic Analysis of Heritable Kidney Cancer Syndromes
Status: RECRUITING
Conditions: Renal Tumor Histology|Kidney Cancer|Renal Cell Carcinoma|Familial Renal Cancer|HLRCC|VHL Syndrome|BAP1 Tumor Predisposition Syndrome|FLCN Gene Mutation|ALK Gene Mutation|FH Gene Mutation|Birt-Hogg-Dube Syndrome|MET Gene Mutation|Cutaneous Leiomyoma|Cutaneous Leiomyomata With Uterine Leiomyomata
Interventions: GENETIC: Gene test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Iron and Vitamin A in School Children
Status: COMPLETED
Conditions: Anemia, Iron Deficiency|Vitamin A Deficiency|Cognitive Development|Helminthic Infection
Interventions: OTHER: Intermittent placebo iron supplement|OTHER: Intermittent iron supplement|OTHER: Placebo Vitamin A|OTHER: High-dose Vitamin A supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial of MRSA Polymerase Chain Reaction for Pneumonia
Status: COMPLETED
Conditions: Pneumonia|Methicillin-Resistant Staphylococcus Aureus
Interventions: OTHER: Polymerase Chain Reaction (PCR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Camrelizumab Plus Apatinib as Maintenance Therapy in Extensive-stage Small-cell Lung Cancer
Status: UNKNOWN
Conditions: Small Cell Lung Carcinoma
Interventions: DRUG: Camrelizumab Plus Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupressure for the Treatment of Raynaud's Phenomenon
Status: COMPLETED
Conditions: Primary Raynaud's Phenomeon
Interventions: OTHER: Acupressure|OTHER: Acupressure dilatation|BEHAVIORAL: education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Vx001 Vaccine in NSCLC Patients
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer Metastatic
Interventions: DRUG: Vx-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT