pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Feasibility of Sentinel Lymph Node Biopsy in Rectal Cancer
Status: TERMINATED
Conditions: Rectal Cancer
Interventions: DRUG: Sienna+ injection|OTHER: MRI scan|PROCEDURE: Surgery to excise rectal cancer|DEVICE: Sentimag probe
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Immunomodulatory Effects of PCSK9 Inhibition
Status: RECRUITING
Conditions: Atherosclerotic Cardiovascular Disease|Cardiovascular Diseases|Atherosclerosis|Arterial Inflammation|Vascular Diseases|Vascular Disease, Peripheral|Vascular Calcification|High Cholesterol/Hyperlipidemia|Heart Diseases|Heart Attack|Stroke|Cerebrovascular Accident|Carotid Artery Diseases|Carotid Atherosclerosis|Transient Ischemic Attack
Interventions: OTHER: 99mTc-tilmanocept SPECT/CT scanning
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ultrasound Guided Single Shot Block of Posterior Tibial Nerve for Postoperative Pain Relief After Hallux Valgus Surgery
Status: UNKNOWN
Conditions: Hallux Valgus
Interventions: DRUG: Ropivacaine 0,75%|PROCEDURE: posterior tibial nerve block|DRUG: morphine and droperidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression
Status: COMPLETED
Conditions: Depressive Disorder|Depression|Depression, Postpartum|Behavioral Symptoms|Mood Disorders|Mental Disorder|Pregnancy Complications|Postpartum Blues|PPD|Postpartum Disorder
Interventions: DRUG: Ganaxolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ALS-008176 in Infants Hospitalized With RSV
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: DRUG: ALS-008176|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Long-Term Extension Study of RoActemra/Actemra (Tocilizumab) in Patients With Early Moderate to Severe Rheumatoid Arthritis Who Completed Study WA19926
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: tocilizumab [RoActemra/Actemra]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral Administration of a Herbarium Mixture (Guazuma Ulmifolia and Tecoma Stans) on Metabolic Profile in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Guazuma Ulmifolia plus Tecoma Stans|DRUG: Calcinaned magnesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging Biomarkers of Neuroplasticity and Neurodegeneration in the Living Human Brain
Status: UNKNOWN
Conditions: Normal Healthy Adults
Interventions: RADIATION: [18F] TRACK|DEVICE: Measurement of Arterial Input Function
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparing Efficacy and Safety of Bmab 1200 and Stelara in Patients With Moderate to Severe Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Moderate to Severe Chronic Plaque Psoriasis
Interventions: BIOLOGICAL: Stelara|BIOLOGICAL: Bmab1200
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Vein Isolation With Versus Without Continued Antiarrhythmic Drugs in Persistent Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: OTHER: Pulmonary vein isolation using CLOSE protocol|DRUG: Antiarrhythmic drug therapy (ADT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Supine Hypertension in Autonomic Failure (CPAP)
Status: RECRUITING
Conditions: Supine Hypertension|Autonomic Failure
Interventions: DEVICE: continuous positive airway pressure (CPAP)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trunk Proprioception in Adolescent Idiopathic Scoliosis
Status: COMPLETED
Conditions: Scoliosis Idiopathic|Scoliosis; Adolescence
Interventions: OTHER: Exercise training- PSSE|OTHER: Exercise training- PSSE with vestibular exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Combining Platelet-rich Plasma With Crystallized Phenol in Pilonidal Sinus Disease
Status: RECRUITING
Conditions: Pilonidal Sinus
Interventions: PROCEDURE: crystallized phenol + platelet rich plasma application|PROCEDURE: crystallized phenol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Chlorella Supplementation on Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Chlorella Vulgaris|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Scheduled Versus Treatment Administration of Donor-Derived Viral Specific T-cells for Viral Infections After Stem Cell Transplant
Status: RECRUITING
Conditions: Allogeneic Stell Cell Transplant|Viral Infection
Interventions: BIOLOGICAL: Viral Specific T-cells (VSTs) Scheduled|BIOLOGICAL: Viral Specific T-cells (VSTs) Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neoadjuvant Accelerated Short Course Radiation Therapy With Proton Beam and Capecitabine for Resectable Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: PROCEDURE: Proton Beam Radiation|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Infarct Tissue Aspiration for Malignant Infarction of Middle Cerebral Artery
Status: TERMINATED
Conditions: Middle Cerebral Artery Infarction
Interventions: PROCEDURE: Stereotactic infarct tissue aspiration|OTHER: Medical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Nitrate on Liver Perfusion and Sugar Control
Status: COMPLETED
Conditions: Type 2 Diabetes|Ageing
Interventions: DIETARY_SUPPLEMENT: Beetroot juice|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Automated Breast Ultrasound and Digital Breast Tomosynthesis Screening Compared to Full Field Digital Mammography in Women With Dense Breasts
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DEVICE: Digital Breast Tomosynthesis|DEVICE: Automated Whole Breast Ultrasound|DEVICE: Full Field Digital Mammography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use of Hyoscyamine Versus Tamsulosin for Management of Ureteral Stent Irritation
Status: TERMINATED
Conditions: Lower Urinary Tract Symptoms
Interventions: DRUG: Hyoscyamine|DRUG: Tamsulosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety, Efficacy, Pharmacokinetic and Pharmacodynamic of Bertilimumab in Patients With Active Moderate to Severe Ulcerative Colitis
Status: UNKNOWN
Conditions: Ulcerative Colitis, Active Moderate|Ulcerative Colitis, Active Severe
Interventions: BIOLOGICAL: Bertilimumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Revlimid Dose 25 mg in Association With (R-CHOP) in the Treatment Follicular Lymphoma
Status: COMPLETED
Conditions: Follicular Lymphoma
Interventions: DRUG: Lenalidomide and R-CHOP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Monotherapy and Combination Immunotherapies in Participants With PD-L1 Positive Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer|Nonsquamous Non Small Cell Lung Cancer|Squamous Non Small Cell Lung Cancer|Lung Cancer
Interventions: DRUG: Domvanalimab|DRUG: Etrumadenant|DRUG: Zimberelimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis Sicca
Status: COMPLETED
Conditions: Keratoconjunctivitis Sicca
Interventions: DRUG: cyclosporine|DRUG: vehicle of OTX-101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Alpha Linolenic Acid (ALA) Supplementation During Pregnancy
Status: WITHDRAWN
Conditions: Omega 3 Supplements During Pregnancy
Interventions: DIETARY_SUPPLEMENT: Alpha Linolenic Acid|DIETARY_SUPPLEMENT: Omega 3 enriched diet ( DHA+EPA)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate RO7204239 in Participants With Facioscapulohumeral Muscular Dystrophy
Status: ACTIVE_NOT_RECRUITING
Conditions: Facioscapulohumeral Muscular Dystrophy (FSHD)
Interventions: DRUG: Placebo|DRUG: RO7204239
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy/ Safety of DNN.22.17.036 in Male Patients With Pattern Hair Loss
Status: NOT_YET_RECRUITING
Conditions: Alopecia
Interventions: DRUG: DNN.22.17.036|DRUG: 10573048700
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TAK-653 Escalating Single and Multiple Dose Study in Healthy Participants
Status: COMPLETED
Conditions: Depressive Disorder
Interventions: DRUG: TAK-653 Placebo|DRUG: TAK-653
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Telephone Counseling-Mailed Materials Versus Internet Interventions in Overweight Cancer Survivors
Status: UNKNOWN
Conditions: Breast Cancer|Colorectal Cancer|Prostate Cancer
Interventions: BEHAVIORAL: Standard Arm (mail/telephone)|BEHAVIORAL: Internet Arm|BEHAVIORAL: Surveys and Questionnaires|BEHAVIORAL: Exercise and Diet
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prophylactic Methylergonovine for Twin Cesarean
Status: RECRUITING
Conditions: Twin; Complicating Pregnancy|Postpartum Hemorrhage
Interventions: DRUG: Methylergonovine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Titanium Elastic Nails in the Treatment of Pediatric Femur Fractures
Status: COMPLETED
Conditions: Femur Fracture
Interventions: PROCEDURE: Elimination of titanium elastic nail prominence at the insertion site and leaving the nails in situ
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Performance and Safety of Eye Drops With Hyaluronic Acid 0.30% and 0.15%
Status: RECRUITING
Conditions: Dry Eye Syndrome (DES)
Interventions: DEVICE: BLUgel A|DEVICE: BLUyal A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypothalamic-Pituitary-Adrenal (HPA)-Axis Study in Pediatric Subjects With Perennial Allergic Rhinitis (PAR)
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: BDP|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetic Study in Healthy Subjects by Dermal Application of a LEO 29102
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: LEO 29102|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Microparticles's Role in the Pathophysiology of Systemic Lupus Erythematosus and Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus|Systemic Scleroderma
Interventions: BIOLOGICAL: blood sample|BIOLOGICAL: urine sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Topical Antibiotics in Chronic Rhinosinusitis
Status: COMPLETED
Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: DRUG: Mupirocin|DRUG: Tobramycin|DRUG: Levofloxacin|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of White Spot Lesions Treated by S-PRG Material and Composite Sealants in Comparison With ICON
Status: COMPLETED
Conditions: White Spot Lesions
Interventions: COMBINATION_PRODUCT: surface pre-reacted glass filler coating material
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Performance Assessment of SARS-CoV-2 Detection Breath Biopsy - SARS-CoV-2 Study
Status: COMPLETED
Conditions: Covid19
Interventions: DEVICE: Breath Biopsy face masks with removable filters and fitted PVA strip|DIAGNOSTIC_TEST: Nasopharyngeal swab|DIAGNOSTIC_TEST: oropharyngeal swabs
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Iloprost Power 15 in Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: iloprost (5 µg)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study Evaluating the Safety, Tolerability, and Initial Efficacy of Single Intravenous Infusion of JWK007 in Patients With Duchenne Muscular Dystrophy (DMD)
Status: RECRUITING
Conditions: Duchenne Muscular Dystrophy
Interventions: BIOLOGICAL: JWK007 Single intravenous infusion administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blood Flow Restriction Exercise in the Treatment of Lateral Epicondylalgia Traditional Treatment
Status: UNKNOWN
Conditions: Tennis Elbow|Lateral Epicondylitis
Interventions: DEVICE: Blood Flow Restriction (BFR)|OTHER: Evidence-informed care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin and S-1 or Oxaliplatin and Capecitabine in Treating Patients With Recurrent, Metastatic, or Unresectable Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: capecitabine|DRUG: oxaliplatin|DRUG: tegafur-gimeracil-oteracil potassium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Emotion and Symptom-Focused Engagement (EASE) for Caregivers
Status: NOT_YET_RECRUITING
Conditions: Trauma and Stressor Related Disorders|Pediatric Cancer|Caregiver Burden
Interventions: BEHAVIORAL: Emotion and Symptom-Focused Engagement (EASE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Can Platelets/Lymphocytes Rate Be New Serological Index for Prognosis of Coronary Heart Disease Complicated With Impaired Glucose Tolerance: Basic Principles and Experimental Design
Status: COMPLETED
Conditions: Coronary Heart Disease Complicated With Impaired Glucose Tolerance
Interventions: BEHAVIORAL: observation|OTHER: Impaired Glucose Tolerance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comprehensive Analysis of Predictors of the Treatment With Pembrolizumab and Olaparib in Patients With Unresectable or Metastatic HER2 Negative Breast Cancer and a Deleterious Germline Mutation or a Homologous Recombination Deficiency (COMPRENDO
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Neoplasm of Breast|Breast Cancer
Interventions: DRUG: Pembrolizumab Injection [Keytruda]|DRUG: Olaparib Oral Tablet [Lynparza]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Standard Chemotherapy Plus BSI-201 (a PARP Inhibitor) in the Neoadjuvant Treatment of Triple Negative Breast Cancer
Status: COMPLETED
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: gemcitabine plus carboplatin plus BSI-201
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glucose Absorption and Gut Hormone Secretion After Gastric Bypass
Status: UNKNOWN
Conditions: Overweight
Interventions: DIETARY_SUPPLEMENT: Glucose|DIETARY_SUPPLEMENT: Glucose + Canagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Thoracic Radiotherapy Plus Durvalumab in Elderly and/or Frail NSCLC Stage III Patients Unfit for Chemotherapy
Status: RECRUITING
Conditions: NSCLC, Stage III
Interventions: DRUG: Durvalumab Injection [Imfinzi]|RADIATION: Thoracic Radiotherapy (TRT) conventionally|RADIATION: Thoracic Radiotherapy (TRT) hypofractionated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of 50% Nitrous Oxide / 50% Oxygen Premix During Liver Biopsy of Focal Lesion
Status: COMPLETED
Conditions: Liver Biopsy
Interventions: DRUG: Kalinox 170 bar|DRUG: Mix of 50% oxygen and 50% nitrogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Assess the Safety, PK and Iron Chelating Activity of DST-0509 (Deferasirox) in Thalassemia Patients Refractory to Chelation
Status: COMPLETED
Conditions: Thalassemia Major
Interventions: DRUG: DST-0509|DRUG: Jadenu|DRUG: Exjade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Bromocriptine on Left Ventricular Function in Women With Peripartum Cardiomyopathy
Status: COMPLETED
Conditions: Peripartum Cardiomyopathy
Interventions: DRUG: Bromocriptine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ublituximab in Combination With Ibrutinib Versus Ibrutinib Alone in Participants With Previously Treated High-Risk Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Ublituximab|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Scalable Digital Delivery of Evidence-based Training for Family to Maximize Treatment Admission Rates of Opioid Use Disorder in Loved Ones
Status: ACTIVE_NOT_RECRUITING
Conditions: Community Reinforcement And Family Training|Family Health|Substance-Related Disorders
Interventions: BEHAVIORAL: Community Reinforcement And Family Training|BEHAVIORAL: We The Village Peer Community Forum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Thalidomide Combined With Chemotherapy and Monotherapy for Maintenance Treatment for Her2-negative Advanced GC
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer Metastatic to Liver
Interventions: DRUG: Thalidomide Combined With Chemotherapy and Monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Moxifloxacin Versus Ofloxacin Plus Metronidazole in Uncomplicated Pelvic Inflammatory Disease: Multicenter Randomized Controlled Trials
Status: COMPLETED
Conditions: Pelvic Inflammatory Disease
Interventions: DRUG: Moxifloxacin|DRUG: Ofloxacin|DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: COMPuter-assisted Self-training to Improve EXecutive Function
Status: RECRUITING
Conditions: Parkinson Disease|Stroke|Cardiac Arrest|Cognitive Dysfunction|Executive Dysfunction
Interventions: BEHAVIORAL: Computer-based cognitive rehabilitation (CBCR)|BEHAVIORAL: General computer-based cognitive stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of dRug-ElutiNg beADs Trans-arterial chemoEmbolization for Hepatocellular Carcinoma in Taiwan
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma Non-resectable|Chemoembolization, Therapeutic
Interventions: DEVICE: Patient records
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The KEN SHE Study on HPV-vaccine Efficacy
Status: ACTIVE_NOT_RECRUITING
Conditions: Papillomavirus Infections
Interventions: BIOLOGICAL: immediate Gardasil 9, delayed MenVeo vaccine|BIOLOGICAL: immediate MenVeo vaccine, delayed Gardasil 9|BIOLOGICAL: immediate Cervarix, delayed MenVeo vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase II Study of Advanced Salivary Gland Carcinoma Based on Molecular Typing
Status: RECRUITING
Conditions: Advanced Salivary Gland Carcinoma
Interventions: DRUG: SHR-A1811|DRUG: SHR 3680 + leuprolide|DRUG: SHR-A1921|DRUG: SHR-A1811
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study Comparing Fibrocaps and Tachosil in Hepatic Surgery
Status: COMPLETED
Conditions: Surgical Bleeding
Interventions: DRUG: Fibrocaps|DRUG: TachoSil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Minimizing Contrast Utilization With IVUS Guidance in Coronary Angioplasty to Avoid Acute Nephropathy
Status: UNKNOWN
Conditions: Acute Kidney Injury|Acute Renal Failure|Acute Renal Injury
Interventions: PROCEDURE: IVUS-guided PCI|PROCEDURE: Angiography-guided PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Efavaleukin Alfa in Subjects With Active Rheumatoid Arthritis
Status: TERMINATED
Conditions: Rheumatoid Arthritis RA
Interventions: DRUG: Efavaleukin alfa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3b/4 Randomised Trial of 3 Doses of Protein-based Covid-19 Vaccine (SpikoGen)
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: Advax-CpG55.2 adjuvanted recombinant spike protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Alflutinib Versus Alflutinib Plus Chemotherapy for NSCLC
Status: NOT_YET_RECRUITING
Conditions: NSCLC
Interventions: DRUG: Chemotherapy|DRUG: Alflutinib plus chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nitrous Oxide For Endoscopic Ablation of Refractory Barrett's Esophagus (NO FEAR-BE)
Status: RECRUITING
Conditions: Barrett Esophagus|Intestinal Metaplasia|Esophageal Dysplasia
Interventions: DEVICE: CryoBalloon Focal Ablation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study to Investigate SER120 Nasal Spray Formulations in Patients With Nocturia
Status: COMPLETED
Conditions: Nocturia
Interventions: DRUG: SER120 (750 ng/day)|DRUG: SER120 (1000 ng/day)|DRUG: SER120 (1500 ng/day)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnosing Clinically Significant Prostate Cancer In African American and White Men With Elevated PSA
Status: ACTIVE_NOT_RECRUITING
Conditions: Health Status Unknown|Elevated PSA
Interventions: PROCEDURE: Biopsy of Prostate|OTHER: Laboratory Biomarker Analysis|DIAGNOSTIC_TEST: Magnetic Resonance Imaging|DIAGNOSTIC_TEST: MRI Ultrasound Fusion Guided Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of a JAK3 Inhibitor for the Prevention of Acute Rejection in Kidney Transplant Patients
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: Cyclosporine|DRUG: CP-690,550|DRUG: CP-690,550
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 18F-2-fluoro-2-deoxy-D-glucose in Positron Emission Tomography Computed Tomography
Status: NOT_YET_RECRUITING
Conditions: Solitary Pulmonary Nodule|Oncology|18F-2-fluoro-2-deoxy-D-glucose|Adverse Event
Interventions: DRUG: 18F-2-fluoro-2-deoxy-D-glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Benson Relaxation Technique Combined With Music Therapy for Fatigue, Anxiety, and Depression in Hemodialysis Patients
Status: COMPLETED
Conditions: Hemodialysis Complication|Fatigue|Anxiety Depression
Interventions: BEHAVIORAL: Benson relaxation combined with music therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Long-term Safety and Tolerability of 0.5 mg Fingolimod in Patients With Relapsing Forms of Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing Forms of Multiple Sclerosis
Interventions: DRUG: Fingolimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FASTER-Tlalpan Study in Mexico: HPV Vaccination Impact on Cervical Cancer Screening Program
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia|HPV-Related Cervical Carcinoma
Interventions: BIOLOGICAL: CERVARIX|BIOLOGICAL: GARDASIL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Skills and Drills Intervention for Emergency Obstetrics and Neonatal Care at First Referral Units of North Karnataka
Status: COMPLETED
Conditions: Obstetric and Perinatal Complications|Postpartum Hemorrhage|Preeclampsia/Eclampsia|Obstructed/Prolonged Labor|Sepsis|Birth Asphyxia
Interventions: OTHER: Skills training|OTHER: Emergency obstetric drills|OTHER: Revised Case Sheets|OTHER: Supportive supervision|OTHER: Referral strengthening
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of High Rebound Mattress Toppers on Sleep and Sleep-Related Symptoms
Status: COMPLETED
Conditions: Sleep Disorders
Interventions: DEVICE: Low rebound mattress toppers|DEVICE: High rebound mattress toppers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pirfenidone for Progressive Fibrotic Sarcoidosis
Status: UNKNOWN
Conditions: Sarcoidosis, Pulmonary
Interventions: DRUG: Pirfenidone|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Recombinant Mycobacterium Tuberculosis ESAT6-CFP10 Allergen
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: ESAT6-CFP10 (10ug/ml) in left arm and TB-PPD in right arm|BIOLOGICAL: ESAT6-CFP10 (10ug/ml) in right arm and TB-PPD in left arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Oncological Care for Patients With Meningioma
Status: UNKNOWN
Conditions: Atypical Meningioma|Clear-cell Meningioma|Chordoid Meningioma|Anaplastic Meningioma|Rhabdoid Meningioma|Papillary Meningioma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Strategies for Optimal Lung Ventilation in ECMO for ARDS: The SOLVE ARDS Study
Status: UNKNOWN
Conditions: Respiratory Distress Syndrome, Adult
Interventions: DEVICE: PHASE 1: impact of tidal ventilation on VILI|DEVICE: PHASE 2: impact of PEEP on VILI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Energy Drinks and Vascular Function
Status: COMPLETED
Conditions: Vascular Function
Interventions: OTHER: energy drink|OTHER: caffeinated drink|OTHER: Energy gum|OTHER: placebo gum|OTHER: Control drink|OTHER: Total sleep deprivation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mercuri Analysis Contribution on Handicap Evaluation in ArthrogypOsis, a Congenital Neuromuscular Disease
Status: COMPLETED
Conditions: Diagnosis of Arthrogryposis Amyoplasia or Distal Arthrogryposis|5 Day Multidisciplinary Evaluation in AMC Clinic of the National Reference Center|With Physical Medecin, Medical Genetic and Imaging Departments at the Hospital Grenoble Alpes
Interventions: OTHER: no intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Using Motivational Interviewing To Reduce Parental Risk-Related Behaviors For Early Childhood Caries
Status: COMPLETED
Conditions: Caries,Dental|Caries
Interventions: BEHAVIORAL: Motivational Interviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Supplemental Oral Curcumin in Patients With Atopic Asthma
Status: COMPLETED
Conditions: Atopic Asthma
Interventions: DIETARY_SUPPLEMENT: CURCUMIN|OTHER: no intervention other than stopping study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Oxygen Therapy for Post-COVID-19 Syndrome
Status: COMPLETED
Conditions: Covid19|Neurocognitive Dysfunction
Interventions: DEVICE: Hyperbaric oxygen|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Teriparatide or Denosumab on Bone in Postmenopausal Women With Osteoporosis
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Teriparatide|DRUG: Denosumab|DRUG: Demeclocycline|DRUG: Tetracycline|DRUG: Calcium Supplement|DRUG: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Olmesartan Effect on Myocardial Viability of Patients With Dilated Cardiomyopathy
Status: UNKNOWN
Conditions: Dilated Cardiomyopathy
Interventions: DIAGNOSTIC_TEST: FDG PET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evidence For Fusion In Spine With Orthoss®
Status: RECRUITING
Conditions: Lumbar Spondylolisthesis Involving L4-L5|Lumbar Spondylolisthesis Involving L5-S1|Lumbar Spinal Stenosis|Lumbar Disc Degeneration
Interventions: DEVICE: Orthoss
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Accuracy and Primary Stability in Immediate Implant Placement: Dynamic Navigation Versus Freehand
Status: ACTIVE_NOT_RECRUITING
Conditions: Tooth Diseases
Interventions: PROCEDURE: dynamic navigation surgery|PROCEDURE: freehand surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Edible Oils in the Treatment of Constipation of Hemodialysis Patients
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: OTHER: Mineral oil|DIETARY_SUPPLEMENT: Olive oil|DIETARY_SUPPLEMENT: Flaxseed oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Research Study of How Well Semaglutide Works in People Living With Overweight or Obesity
Status: COMPLETED
Conditions: Overweight|Obesity|Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide|DRUG: Placebo (semaglutide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Avastin® With Pemetrexed +/- Carboplatin to Treat Elderly Patients With Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-squamous Non-small Cell Lung Cancer
Interventions: DRUG: Bevacizumab + Pemetrexed|DRUG: Bevacizumab + Pemetrexed + Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Tranexamic Acid After Vaginal Delivery With Episiotomy a RCT Placebo Control Trail
Status: RECRUITING
Conditions: Episiotomy Wound|Anemia|Early Postpartum Hemorrhage|Hemoglobin
Interventions: DRUG: Tranexamic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Subtenon and Intravenous Dexmedetomidine Effect on Patients Undergoing Cataract Surgery
Status: UNKNOWN
Conditions: Acute Postoperative Pain
Interventions: DRUG: Dexmedetomidine|DRUG: lidocaine 2%|DRUG: bupivacine 0.5%|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Capecitabine ON Temozolomide Radionuclide Therapy Octreotate Lutetium-177 NeuroEndocrine Tumours Study
Status: COMPLETED
Conditions: Midgut Neuroendocrine Tumours|Pancreatic Neuroendocrine Tumours
Interventions: DRUG: octreotate|DRUG: Capecitabine|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: tDCS and Physical Therapy in Stroke
Status: COMPLETED
Conditions: Cerebrovascular Accident
Interventions: DEVICE: Active transcranial Direct Current Stimulation / Constraint Induced Movement Therapy|DEVICE: Sham transcranial Direct Current Stimulation / Constraint Induced Movement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of SHR-8068 Combined With Adebrelimab and Platinum-containing Chemotherapy in the Treatment of Advanced Gastric and Esophageal Cancer
Status: RECRUITING
Conditions: Advanced Gastric Adenocarcinoma and Esophageal Squamous Cell Carcinoma
Interventions: DRUG: SHR-8068;Adebrelimab;Oxaliplatin;Capecitabine Tablets;Paclitaxel Injection;Cisplatin Injection|DRUG: Adebrelimab;Oxaliplatin;Capecitabine Tablets;Paclitaxel Injection;Cisplatin Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Chemoprevention Drugs for School-based Malaria Control
Status: COMPLETED
Conditions: Malaria,Falciparum|Anemia in Children
Interventions: DRUG: Dihydroartemisinin-Piperaquine|DRUG: Chloroquine|DRUG: Sulfadoxine pyrimethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Rolapitant as an Antiemetic in Malignant Glioma Patients Receiving Radiotherapy and Temozolomide
Status: COMPLETED
Conditions: Chemo-radiation Induced Nausea and Vomiting
Interventions: DRUG: Rolapitant|DRUG: Ondansetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2027 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: E2027|DRUG: E2027 matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Using Clinical Prediction Models to Improve Treatment for Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: ACCEPT Decision Intervention|OTHER: Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Correlation of Antibody Response to COVID-19 Vaccination in Pregnant Woman and Transplacental Passage Into Cord Blood.
Status: COMPLETED
Conditions: Covid-19
Interventions: DIAGNOSTIC_TEST: COVID-19 Spike Protein IgG Quantitative Antibody (CMIA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of CRet Associated With Functional Massage (F.M) on Gait and Functionality in Post-stroke Spasticity
Status: COMPLETED
Conditions: Stroke Sequelae|Spasticity, Muscle|Massage|Electrotherapy
Interventions: DEVICE: CRet|DEVICE: Sham CRet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Lidocaine Infusion as a Sole Analgesic Versus Morphine in Laparoscopic Gastric Bypass Surgery
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Lidocaine Hydrochloride 2% Intravenous Solution [XYLOCAINE]|DRUG: morphine sulphate (10mg/ ml ampoule)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Topical Application of Tranexamic Acid for Saving Blood Losses in Patients Subjected to Prosthetic Knee Surgery
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Amchafibrin|OTHER: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anterior Cruciate Ligament Reconstruction Using Single Bundle and Double Bundle Techniques
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament Injury
Interventions: PROCEDURE: Single bundle anterior cruciate ligament reconstruction|PROCEDURE: Double bundle anterior cruciate ligament reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Integrated Mindfulness-based Cognitive Behaviour Therapy Versus Cognitive Behaviour Therapy for Provoked Vestibulodynia
Status: COMPLETED
Conditions: Provoked Vestibulodynia
Interventions: BEHAVIORAL: Mindfulness-based Cognitive Therapy|BEHAVIORAL: Cognitive Behavioural Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk Stratification and Early Prevention Strategies for Non-compaction of Ventricular Myocardium (CAPTAIN)
Status: NOT_YET_RECRUITING
Conditions: Isolated Noncompaction of the Ventricular Myocardium
Interventions: BIOLOGICAL: Diagnosis of NVM|BIOLOGICAL: Diagnosis of NVM|BIOLOGICAL: Diagnosis of NVM
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of a Vaccine Against Respiratory Syncytial Virus (RSV) When Given Alone and Together With a Vaccine Against Diphtheria, Pertussis and Tetanus (Tdap) Viruses Followed by a 2nd Dose of the RSV Vaccine to Healthy Non-Pregnant Women
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: RSVPreF3 formulation 3|BIOLOGICAL: RSVPreF3 formulation 2|BIOLOGICAL: Boostrix-ex-US|BIOLOGICAL: Boostrix-US|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of VIldagliptin aS an Add-on Therapy to Metformin Compared to Metformin Up-TitratION in Chinese Patients With Type 2 Diabetes.(VISION)
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Metformin|DRUG: vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementing a Hospital-Based Walking Program (STRIDE): Function QUERI 2.0
Status: ACTIVE_NOT_RECRUITING
Conditions: Early Ambulation
Interventions: OTHER: Implementation Strategy: Foundational Support|OTHER: Implementation Strategy: Enhanced Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy of Proellex in Pre-Menopausal Anemic Women With Symptomatic Uterine Fibroids
Status: TERMINATED
Conditions: Uterine Fibroids|Anemia
Interventions: DRUG: Proellex 25 mg|DRUG: Proellex 50 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate The Efficacy And Safety Of Varenicline Compared To Placebo For Smoking Cessation Through Reduction
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Varenicline Tartrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Cinnamon Cassia on Diabetes Control and Cardiometabolic Risk Factors in Adults With Type 2 Diabetes Mellitus
Status: WITHDRAWN
Conditions: Diabetes Mellitus
Interventions: DRUG: Cinnamon|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Expanded HIV Care in Opioid Substitution Treatment (EHOST) Trial
Status: COMPLETED
Conditions: Opioid Use Disorder|HIV
Interventions: OTHER: Expanded HIV care in Opioid Substitution Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Trial of Remdesivir in Adults With Severe COVID-19
Status: TERMINATED
Conditions: COVID-19|Remdesivir|SARS-CoV-2
Interventions: DRUG: Remdesivir|DRUG: Remdesivir placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Laboral Kinesiotherapy in Prevention of Upper Limb Musculoskeletal Disorders
Status: UNKNOWN
Conditions: Upper Limb; Injury, Superficial, Multiple
Interventions: OTHER: Labor Kinesiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Diabeloop WP7 : Crossover Evaluation of the Safety and the Efficacy of Artificial Pancreas Diabeloop (WP7)
Status: COMPLETED
Conditions: Closed Loop|Diabetes Mellitus, Type 1
Interventions: DEVICE: Continuous Glucose Monitoring|DEVICE: External Insulin Pump|OTHER: telemdecine|DEVICE: The Diabeloop Software (Model predictive control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Advanced Genital Prolapse Surgery With and Without Mid Urethral Sling to Prevent Stress Urinary Incontinence
Status: UNKNOWN
Conditions: Pelvic Organ Prolapse|Urinary Stress Incontinence
Interventions: DEVICE: Midurethral sling|PROCEDURE: Genital prolapse surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT