pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Vinorelbine, Gemcitabine, and Docetaxel Compared With Paclitaxel and Carboplatin in Treating Patients With Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: docetaxel|DRUG: gemcitabine hydrochloride|DRUG: paclitaxel|DRUG: vinorelbine tartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Health of Pessary Versus Progesterone Supplement for Preventing Preterm Birth Children
Status: COMPLETED
Conditions: Preterm Birth
Interventions: OTHER: Developmental score according to The Ages & Stages Questionnaires®, Third Edition - ASQ®-3|OTHER: Physical development and General Health|OTHER: Developmental Red flags
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The OPTICA Study - The Optimised Computed Tomography Pulmonary Angiography (CTPA) in Pregnancy, Quality and Safety Study
Status: UNKNOWN
Conditions: Pulmonary Embolism|Pregnancy Related|Venous Thromboembolism
Interventions: DIAGNOSTIC_TEST: OPTICA CTPA Protocol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MINT I Multi- Institutional Neo-adjuvant Therapy MammaPrint Project I
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: TAC chemotherapy|DRUG: TC chemotherapy|DRUG: Dose Dense AC or FEC100 followed by paclitaxel or docetaxel chemotherapy|DRUG: TCH chemotherapy|DRUG: T + trastuzumab followed by CEF + trastuzumab|DRUG: Dose dense AC followed by T + trastuzumab|DRUG: Dose dense AC followed by T + trastuzumab + pertuzumab|DRUG: PTH followed by dose dense AC of FEC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Assess the Safety of GSK Biologicals' Liquid Human Rotavirus Vaccine in Healthy Infants
Status: COMPLETED
Conditions: Infections, Rotavirus
Interventions: BIOLOGICAL: GSK Biologicals' human rotavirus vaccine 444563|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Docetaxel With or Without Vandetanib in Treating Patients With Metastatic Stomach Cancer or Gastroesophageal Junction Cancer
Status: TERMINATED
Conditions: Gastric Cancer
Interventions: DRUG: docetaxel|DRUG: vandetanib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short-course Benznidazole Treatment to Reduce Trypanosoma Cruzi Parasitic Load in Women of Reproductive Age
Status: RECRUITING
Conditions: Chagas Disease
Interventions: DRUG: Benznidazole|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Intervention for Young Adults With Diabetes: Resilient, Empowered, Active Living-Telehealth (REAL-T)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: BEHAVIORAL: Resilient, Empowered, Active Living-Telehealth (REAL-T)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of 162, a Novel Neutralizing Antibody Targeting Hepatitis B Surface Antigen, in Healthy Adult Subjects
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: BIOLOGICAL: 162|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Etodolac Extended Release Tablets USP 600mg Under Fed Condition
Status: COMPLETED
Conditions: Fasting
Interventions: DRUG: Etodolac Extended Release Tablets USP 600mg|DRUG: Etodolac Extended Release Tablets 600mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Apatinib as Third-line and Later Therapy in Patients With Small Cell Lung Cancer (SCLC)
Status: UNKNOWN
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Apatinib Mesylate tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3375880 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3375880 IV|DRUG: LY3375880 SC|DRUG: Placebo IV|DRUG: Placebo SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Coenzyme Q10 and Meclofenoxate in Hepatic Encephalopathy
Status: UNKNOWN
Conditions: Hepatic Encephalopathy|Coenzyme Q10|Intellectual Functioning Disability
Interventions: DRUG: Coenzyme Q10|DRUG: MECLOFENOXATE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nurse PIV Insertion Success With and Without Assistive Devices in Patients 0-12 Months of Age
Status: TERMINATED
Conditions: PIV Catheter Insertion|Vein Visualization
Interventions: PROCEDURE: Unassisted vein visualization|PROCEDURE: Wee Sight® Transilluminator|PROCEDURE: VeinViewer® (Christie Digital Systems, Cypress, CA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Healthy Moms: Prenatal Counseling for Postpartum Health
Status: COMPLETED
Conditions: Pregnancy Related|Breastfeeding|Maternal Care Patterns
Interventions: BEHAVIORAL: Breastfeeding|BEHAVIORAL: Smokefree Homes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Non-Invasive Brain Stimulation and Substance Use
Status: COMPLETED
Conditions: Substance Use Disorders
Interventions: DEVICE: Transcranial Alternating Current Stimulation at 10 Hz|DEVICE: Transcranial Alternating Current Stimulation at 40 Hz|DEVICE: Active sham transcranial alternating current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hospital-Community-Family-Care Management Platform for Chronic Heart Failure
Status: UNKNOWN
Conditions: Chronic Heart Failure
Interventions: OTHER: Hospital-Community-Family-Care Management Platform Online|OTHER: Subjects with CHF via conventional clinic visit according to the latest relevant guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of rTMS and VCT on Upper Limb Function in Patients With Stroke
Status: UNKNOWN
Conditions: Cerebral Vascular Accident
Interventions: DEVICE: intermittent theta burst stimulation|DEVICE: continuous theta burst stimulation|DEVICE: iTBS+cTBS group|DEVICE: sham theta burst stimulation|DEVICE: VCT|DEVICE: VCT+optimal rTMS group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Anti-PD1 Antibody-activated TILs in Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: anti-PD1 antibody-activated TILs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase IIIb Study of the Safety, Efficacy, and Tolerability of Switching to a Fixed-dose Combination of Abacavir/Dolutegravir/ Lamivudine From Current Antiretroviral Regimen
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: ABC/DTG/3TC FDC|DRUG: Ongoing cART regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Diclofenac Sodium Gel 3% to Solaraze® (Diclofenac Sodium) Gel 3% in the Treatment of Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Diclofenac sodium|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Perineural Injection Therapy in Primary Fibromyalgia
Status: NOT_YET_RECRUITING
Conditions: Fibromyalgia, Primary
Interventions: PROCEDURE: Perineural Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of General Anesthesia on Quality of Recovery After Transaxillary Endoscopic Breast Augmentation
Status: COMPLETED
Conditions: Breast Augmentation|Inhalation Anesthesia|Total Intravenous Anesthesia|Quality of Recovery
Interventions: DRUG: Desflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Different Energy Sources During TUR-P
Status: SUSPENDED
Conditions: Benign Prostatic Hypertrophy
Interventions: PROCEDURE: Bipolar TURP-1|PROCEDURE: Bipolar TURP-2|PROCEDURE: Monopolar TURP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Sofosbuvir/Ledipasvir Treatment on the Pharmacokinetics and Renal Safety of Tenofovir
Status: COMPLETED
Conditions: Hepatitis C and HIV Coinfection
Interventions: OTHER: Blood draws for tenofovir PK, renal function
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Pilot Study of Exercise in Patients With Docetaxel-Based Chemotherapy for Hormone Refractory Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasms|Neoplasm Metastasis|Palliative Care
Interventions: BEHAVIORAL: Exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Protocol for the Treatment of Patients With Previously Untreated Chronic Lymphocytic Leukemia With a Combination of Bendamustine and Ofatumumab
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia (CLL)
Interventions: DRUG: ofatumumab + bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Study of Primary Tumor Radiotherapy for Patients With MPE Stage IV NSCLC
Status: UNKNOWN
Conditions: Malignant Pleural Effusion|Nonsmall Cell Lung Cancer, Stage IV
Interventions: RADIATION: Radiation|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intracanalicular Dexamethasone Insert for the Treatment of Inflammation and Discomfort in Dry Eye Disease (DEcIDED)
Status: RECRUITING
Conditions: Dry Eye
Interventions: DRUG: Dextenza (IDI) (Sustained Release Dexamethasone), (0.4 mg)|OTHER: ProLong™ collagen plugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Heterogeneously Hypofractionated Radiotherapy for Locally Advanced NSCLC
Status: RECRUITING
Conditions: Stage III Non-small-cell Lung Cancer|Stage IV Non-small Cell Lung Cancer|Radiotherapy Side Effect
Interventions: RADIATION: Heterogeneously Hypofractionated Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Clinical Outcomes According to High-protein Provision in Critically Ill Patients After Abdominal Surgery
Status: NOT_YET_RECRUITING
Conditions: Protein Malnutrition
Interventions: DIETARY_SUPPLEMENT: Active protein supplementation|DIETARY_SUPPLEMENT: Conventional protein supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Vestibular Perceptual Learning on Vestibular Thresholds and Balance
Status: NOT_YET_RECRUITING
Conditions: Healthy Aging
Interventions: BEHAVIORAL: Vestibular Perceptual Learning|BEHAVIORAL: Placebo Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Arthroscopic Transosseous vs. Anchored Rotator Cuff Repair
Status: WITHDRAWN
Conditions: Shoulder Pain Chronic|Shoulder Pain|Rotator Cuff Tear|Rotator Cuff Injury
Interventions: DEVICE: Tensor Tunnler|PROCEDURE: Anchor Rotator Cuff Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Talazoparib, a PARP Inhibitor, in Patients With Advanced or Recurrent Solid Tumors
Status: COMPLETED
Conditions: Advanced or Recurrent Solid Tumors|Breast Neoplasms|Ovarian Cancer, Epithelial|Ewing Sarcoma|Small Cell Lung Carcinoma|Prostate Cancer|Pancreas Cancer
Interventions: DRUG: Talazoparib
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Ultrafiltration (UF) vs. Usual and Customary Care for Patients With Severe Heart Failure (HF)
Status: COMPLETED
Conditions: Heart Failure|CHF
Interventions: DRUG: IV loop diuretic|DEVICE: NxStage System One
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Antenatal Treatment of Alloimmune Thrombocytopenia
Status: COMPLETED
Conditions: Alloimmune Thrombocytopenia|Fetal Alloimmune Thrombocytopenia
Interventions: DRUG: IVIG (Intravenous Immunoglobulin)|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study For Treatment Of Paroxysmal Atrial Fibrillation (PAF) With The THERMOCOOL SMARTTOUCH SF Catheter and TRUPULSE Generator
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: Pulsed Field (PF) /Radiofrequency (RF) Catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Latera RCT - Latera vs. Sham Control for Lateral Nasal Valve Collapse
Status: COMPLETED
Conditions: Nasal Valve Collapse|Nasal Breathing
Interventions: DEVICE: Latera Implant|DEVICE: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: E-Nose: Diagnostic Tool for Pleural TB
Status: UNKNOWN
Conditions: Tuberculosis, Pleural
Interventions: OTHER: Medical History|DEVICE: E-Nose|OTHER: Chest CT|OTHER: Pleural Fluid Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Hyperpolarized Xenon MRI for Assessment of Pulmonary Function in Lung Resection
Status: COMPLETED
Conditions: Pulmonary Surgical Procedures
Interventions: DRUG: 129Xe MRI|DRUG: 133 Xe scintigraphy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Safety and Efficacy Study of Cryopreserved OTL-200 for Treatment of Metachromatic Leukodystrophy (MLD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Lysosomal Storage Disease|Metachromatic Leukodystrophy
Interventions: GENETIC: OTL-200
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nintedanib in Treating Patients With Recurrent or Persistent Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Adenocarcinoma|Endometrial Clear Cell Adenocarcinoma|Endometrial Mucinous Adenocarcinoma|Endometrial Serous Adenocarcinoma|Endometrial Squamous Cell Carcinoma|Endometrial Transitional Cell Carcinoma|Endometrial Undifferentiated Carcinoma|Malignant Uterine Corpus Mixed Epithelial and Mesenchymal Neoplasm|Recurrent Uterine Corpus Carcinoma
Interventions: DRUG: Nintedanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Recombinant Factor IX Product, IB1001, in Subjects With Hemophilia B
Status: COMPLETED
Conditions: Hemophilia B
Interventions: BIOLOGICAL: IB1001|BIOLOGICAL: nonacog alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of VI-0521 Compared to Placebo in Treatment of Diabetes and Obesity in Adults With Obesity-Related Co-Morbid Conditions
Status: COMPLETED
Conditions: Obesity|Type 2 Diabetes
Interventions: DRUG: VI-0521|DRUG: VI-0521|DRUG: VI-0521
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Afatinib Monotherapy in Patients With ERBB-deregulated Metastatic Urothelial Tract Carcinoma After Failure of Platinum Based Chemotherapy
Status: COMPLETED
Conditions: Urologic Neoplasms
Interventions: DRUG: Afatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Better Resiliency Among Veterans With Omega-3's (BRAVO) Study
Status: TERMINATED
Conditions: Suicide
Interventions: DRUG: Study Juice|DRUG: Placebo Juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study to Evaluate the Contact Sensitizing Potential of Topically Applied ZuraPrep™ and ZuraPrep™ Without IPA
Status: COMPLETED
Conditions: Surgical Site Infection
Interventions: DRUG: Chloraprep|DRUG: 0.9% Physiological Saline|OTHER: ZuraPrep without IPA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Short Course Radiation Therapy Followed by Pre-operative Chemotherapy and Surgery in High-risk Rectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Rectal Cancer
Interventions: COMBINATION_PRODUCT: radiotherapy, capecitabine, oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of a Combination of TeaCrine®, Dynamine, and Caffeine in Law Enforcement
Status: COMPLETED
Conditions: Caffeine, Teacrine, and Dynamine: Effects on Performance
Interventions: DRUG: Caffeine+TeaCrine+Dynamine|DRUG: Placebo|DRUG: Caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Incretin-based Therapy in Early Diagnosed Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Victoza® (liraglutide)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Screening for Hypoglycemia in an Institutionalized Elderly Diabetic Population.
Status: COMPLETED
Conditions: Old Age|Institutionalized in EHPAD (French Nursing Home)|Diabetes|Hypoglycemic Syndrome
Interventions: DEVICE: Continuous interstitial glucose sensor|OTHER: Sensor Scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Assessment of T4030 Eye Drops Versus Ganfort® UD in Ocular Hypertensive or Glaucomatous Patients.
Status: COMPLETED
Conditions: Ocular Hypertension Glaucoma
Interventions: COMBINATION_PRODUCT: Bimatoprost Timolol (T4030)|COMBINATION_PRODUCT: Bimatoprost Timolol (Ganfort)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Fingolimod in de Novo Patients Versus Fingolimod in Patients Previously Treated With a First Line Disease Modifying Therapy
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: Fingolimod (FTY720)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 52-Week, Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Evaluate the Safety and Tolerability of GSK573719/GW642444 and GSK573719 in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: 125/25 mcg once-daily GSK573719/GW642444|DRUG: 125mcg once-daily GSK573719|DRUG: Placebo once-daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Hemodynamic Effects of Different Volumes of Bupivacaine 0.25% Caudal Blocks in Pediatrics Undergoing Lower Abdominal Surgeries as Measured by Electrical Cardiometry
Status: COMPLETED
Conditions: Anesthesia, Caudal|Pediatrics
Interventions: DRUG: Bupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Benefit of FDG PET CT in the Treatment Algorithm of Staphylococcus Aureus Bacteremia
Status: COMPLETED
Conditions: Staphylococcus Aureus Bacteremia
Interventions: PROCEDURE: FDG PET CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Lattice Stereotactic Body Radiation Therapy (Lattice SBRT) for Localized Unresectable or Metastatic Conventional Type Chondrosarcoma
Status: WITHDRAWN
Conditions: Metastatic Chondrosarcoma
Interventions: RADIATION: Lattice stereotactic body radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Bracing With Co-aptation Splinting for the Initial Treatment of Acute Humeral Shaft Fractures: The COBRAS Trials
Status: RECRUITING
Conditions: Humeral Fractures
Interventions: PROCEDURE: Webril Padded Plaster Splint|PROCEDURE: Pre-Fabricated Fracture Brace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LDK378 in Patients With Non-small Cell Lung Cancer Harboring ROS1 Rearrangement
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer Harboring ROS1 Rearrangement
Interventions: DRUG: LDK378(Ceritinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety of UC-MSC Transplantation in Patients With Retinitis Pigmentosa
Status: ENROLLING_BY_INVITATION
Conditions: Retinitis Pigmentosa
Interventions: BIOLOGICAL: Conditioned Medium (CM)|BIOLOGICAL: Umbilical Cord Mesenchymal Stem Cell (UC-MSC)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Tolerability and Pharmacokinetics of Increasing Repeated Doses of BIIF 1149 BS in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIIF 1149 BS - single rising dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Axi-cel in CNS Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma|Lymphoma Cns
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide|BIOLOGICAL: Axicabtagene Ciloleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Remote Postconditioning on Graft Function in Patients Undergoing Living-related Kidney Transplantation
Status: COMPLETED
Conditions: Kidney Transplantation|Ischemic Reperfusion Injury|Remote Ischemic Postconditioning
Interventions: DEVICE: remote ischemic postconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Low-dose Interleukin-2 in Combination With Standard Therapy on Idiopathic Inflammatory Myopathy
Status: UNKNOWN
Conditions: Inflammatory Myopathy
Interventions: DRUG: Interleukin-2|DRUG: ciclosporin and corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Immediate and Delayed Implant Placement Using Socket Shield Technique and Autogenous Dentin Graft
Status: COMPLETED
Conditions: Dental Implant|Tooth Loss|Socket Shield
Interventions: OTHER: Immediate implant|OTHER: Delayed implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Fructose Consumption on Intestinal Permeability in Non-alcoholic Fatty Liver Disease (NAFLD) - a Pilot Study.
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease|Non-alcoholic Steatohepatitis
Interventions: DIETARY_SUPPLEMENT: High oral Fructose challenge (150g per day for 28 days)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety/Efficacy Study to Assess Whether FVIII/VWF Concentrate Can Induce Immune Tolerance in Haemophilia A Patients
Status: UNKNOWN
Conditions: Hemophilia A
Interventions: DRUG: Plasma-derived FVIII/VWF concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Astragalus Membranaceus in the Patients After Stroke With Fatigue
Status: UNKNOWN
Conditions: Fatigue|Stroke
Interventions: DRUG: Chinese Herb Astragalus membranaceus|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrafast Ultrasound Imaging Assesment of Carotid Plaque Neovascularization
Status: COMPLETED
Conditions: Carotid Stenosis|Carotid Artery Diseases|Carotid Atherosclerosis|Carotid Artery Plaque|Atheroma; Carotid Artery
Interventions: DEVICE: contrast enhanced ultrafast ultrasound imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety Study of PRTX-100 With Methotrexate or Leflunomide to Treat Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: PRTX-100 at 1.5 mcg/kg|DRUG: PRTX-100 at 3.0 mcg/kg|DRUG: PRTX-100 at 6.0 mcg/kg|DRUG: PRTX-100 at 12.0 mcg/kg|DRUG: PRTX-100 at 240 mcg|DRUG: Placebo|DRUG: PRTX-100 at 420 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Imiquimod Cream in Combination With Cryotherapy for the Treatment of Actinic Keratoses
Status: COMPLETED
Conditions: Actinic Keratoses
Interventions: DRUG: imiquimod 5% cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients With Fasting Dysglycemia
Status: COMPLETED
Conditions: Dysglycemia
Interventions: DIETARY_SUPPLEMENT: Reglicem|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Investigation Into the Therapeutic Dosage of Fondaparinux Sodium, a Medication Used to Prevent Blood Clots in Morbidly Obese Volunteers
Status: COMPLETED
Conditions: Venous Thrombosis|Pulmonary Embolism
Interventions: DRUG: Fondaparinux Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Judging the Efficacy of Secukinumab in Patients With Psoriasis Using AutoiNjector: a Clinical Trial Evaluating Treatment Results (JUNCTURE)
Status: COMPLETED
Conditions: Plaque-type Psoriasis
Interventions: DRUG: Placebo|DRUG: Secukinumab 150mg|DRUG: Secukinumab 300mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Investigation of Dietary Supplementation and the Effect on Common Symptoms of Perimenopause and Menopause
Status: COMPLETED
Conditions: Menopause|Menopause Related Conditions|Perimenopausal Disorder
Interventions: DIETARY_SUPPLEMENT: Semaine Menopause Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Examine Olaparib Maintenance Retreatment in Patients With Epithelial Ovarian Cancer.
Status: COMPLETED
Conditions: Epithelial Ovarian Cancer
Interventions: DRUG: Active Comparator: Olaparib tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TAP Block With Two Different Doses of Levobupivacaine
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: Levobupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Exogenous Ketones on Indices of Keto-Adaptation in Obese Subjects on Weight Reducing Diets.
Status: COMPLETED
Conditions: Ketogenic Diet|Weight Loss
Interventions: OTHER: Diet|BIOLOGICAL: Blood Draw|BIOLOGICAL: Ketone/Glucose Monitoring|OTHER: Body Composition|BIOLOGICAL: Urine Analysis|BEHAVIORAL: Neuropsychological Measures - ANAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vitamin D Regulates the Expression of Glucocorticoid Receptors in Blood of Severe Asthmatic Patients
Status: COMPLETED
Conditions: Effect of Drug
Interventions: DRUG: Vitamin D|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Psychological Intervention for Persons in the Early Initial Prodromal State
Status: UNKNOWN
Conditions: Schizophrenia|Psychosis
Interventions: BEHAVIORAL: Cognitive behavioral therapy (CBT)|BEHAVIORAL: Supportive Counselling (SC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SBRT for Extra-cranial Oligorecurrent Tumor
Status: UNKNOWN
Conditions: Recurrent Cancer
Interventions: RADIATION: SBRT|DRUG: systemic therapy (chemotherapy, hormon therapy, target therapy etc)|RADIATION: palliative RT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaginal Microbiome Transplantation for Recurrent Bacterial Vaginosis
Status: RECRUITING
Conditions: Bacterial Vaginoses
Interventions: BIOLOGICAL: Vaginal Microbiome Transplantation (VMT)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 2 Part Study to Assess the Relative Bioavailability of Tablet Formulation Compared to Capsule Formulation and the Effect of Food and Taste Assessment on the Tablet Formulation in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: RO7017773 Phase I Capsule|DRUG: RO7017773 Phase II Tablet Unflavored|DRUG: RO7017773 Phase II Tablet Sweetened/Flavored
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of LAS41003 in the Treatment of Intertriginous Candida Infections
Status: COMPLETED
Conditions: Candidiasis
Interventions: DRUG: LAS41003|DRUG: LAS189962|DRUG: LAS189961
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of STRO-002 in Chinese Adults With Epithelial Ovarian Cancer and Other Advanced Malignant Solid Tumors
Status: RECRUITING
Conditions: Neoplasm Malignant
Interventions: BIOLOGICAL: STRO-002
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PEMF Therapy to Treat Interstitial Cystitis/Bladder Pain Syndrome
Status: COMPLETED
Conditions: Interstitial Cystitis|Chronic Interstitial Cystitis|Bladder Pain Syndrome
Interventions: DEVICE: Pulsed Electromagnetic Field (PEMF) Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Corneal Endothelial Cell Density in Subjects Who Have Had a Fluocinolone Acetonide Implant
Status: COMPLETED
Conditions: Inflammation|Uveitis
Interventions: PROCEDURE: Fluocinolone Acetonide 0.59 mg|PROCEDURE: Fluocinolone Acetonide 2.1 mg
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CMP-001 in Combination With Nivolumab in Subjects With Advanced Melanoma
Status: COMPLETED
Conditions: Melanoma|Advanced Melanoma|Metastatic Melanoma|Unresectable Melanoma
Interventions: DRUG: CMP-001|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Varying the Protein and Dietary Fiber Content of Energy Bars on Their Glycemic and Insulinemic Impact
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: OTHER: Control 1|OTHER: Control 2|OTHER: 15/0|OTHER: 15/0LS|OTHER: 15/5|OTHER: 10/5|OTHER: 10/10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Characterization of Bovine Adrenal Medulla as a New Surrogate Model of Non-histaminergic Itch
Status: COMPLETED
Conditions: Itch
Interventions: DRUG: A-967079 and BAM8-22 application|DRUG: A-967079 and BAM8-22 application after 5 minutes.|DRUG: A-967079 application.|DRUG: Vehicle and BAM8-22 application.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pyrotinib Combined With Docetaxel in the First-line Treatment of HER2-positive MBC
Status: UNKNOWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Pyrotinib Maleate combine with Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ticagrelor De-escalation Strategy in East Asian Patients With AMI
Status: UNKNOWN
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Ticagrelor 90mg|DRUG: Ticagrelor 60/45mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Finding of Retinoid 9cUAB30 in Healthy Volunteers
Status: TERMINATED
Conditions: Healthy, no Evidence of Disease
Interventions: DRUG: retinoid 9cUAB30|OTHER: placebo|OTHER: pharmacological study|OTHER: laboratory biomarker analysis|OTHER: cancer prevention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Iron, Alpha-Synuclein, and Lymphocyte-activation Gene-3 in Ischemic Stroke
Status: COMPLETED
Conditions: Brain Ischemia
Interventions: DIAGNOSTIC_TEST: Serum Iron|DIAGNOSTIC_TEST: RBCs Alpha-synuclein|DIAGNOSTIC_TEST: Serum Soluble lymphocyte activation gene|RADIATION: Brain computed tomography|DIAGNOSTIC_TEST: Brain Iron|DIAGNOSTIC_TEST: Brain Alpha-synuclein|DIAGNOSTIC_TEST: Brain lymphocyte activation gene|DRUG: Deferoxamine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Indirect Resin Composite Inlays Cemented With a Self-adhesive, Self-etch or a Conventional Resin Cement
Status: COMPLETED
Conditions: Dental Leakage
Interventions: PROCEDURE: Etching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Down Syndrome (DS) and Alzheimer's Disease (AD)
Status: COMPLETED
Conditions: Down Syndrome|Alzheimer's Dementia
Interventions: PROCEDURE: biospecimen collection|OTHER: cognitive assessments|OTHER: caregiver questionnaire|PROCEDURE: Florbetapir F18 imaging|PROCEDURE: MRI|PROCEDURE: Fludeoxyglucose F18 (FDG)|PROCEDURE: Tau Pet|PROCEDURE: Actigraphy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nitroglycerin Skin Patches for Facilitating Cervical Ripening: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Induction of Labor Affected Fetus / Newborn
Interventions: DRUG: Nitroderm TTS|DRUG: Dinoprostone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Immunogenicity and Efficacy of HBsAg Vaccine in Combination With Standard Antiviral Therapy With HB110E
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: HBsAg vaccine with Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Clinical Study of QLM3004 in Delaying Myopia in Children
Status: RECRUITING
Conditions: Myopia
Interventions: DRUG: QLM3004 Concentration 1|DRUG: QLM3004 Concentration 2|DRUG: QLM3004 Concentration 3|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The HistoSonics Edison™ System for Treatment of Primary Solid Renal Tumors Using Histotripsy (#HOPE4KIDNEY)
Status: RECRUITING
Conditions: Renal Cancer|Tumor, Solid|Kidney Cancer|Tumor|Tumor, Benign
Interventions: DEVICE: HistoSonics Edison System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Lenvatinib in Advanced Cervical Cancer
Status: RECRUITING
Conditions: Cervical Cancer|Metastatic Cervical Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BLa80 Improve Drinkers' Gut Microbiota
Status: NOT_YET_RECRUITING
Conditions: Alcohol Drinking, Adult Disease
Interventions: DIETARY_SUPPLEMENT: BLa80
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Ability of 99mTc-Tilmanocept to Identify Clipped Nodes in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy and Sentinel Lymph Node Dissection
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: 99m Tc-TM
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Proof of Concept Study of IMMUNOadsorption Therapy in Patients With Idiopathic Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Idiopathic Pulmonary Arterial Hypertension
Interventions: DEVICE: TheraSorb® - Ig flex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Ascending Intravenous Doses of PF-05231023 In Adult Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: PF-05231023|DRUG: PF-05231023|DRUG: PF-05231023|DRUG: PF-05231023|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intrapulmonary Percussion Ventilation on Deposition of Inhaled Aerosols in Idiopathic Pulmonary Fibrosis
Status: RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DEVICE: intrapulmonary percussive ventilation|RADIATION: delivery of 99mTc-DTPA aerosol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Peer-to-Peer (VP2P) Support Mentoring for Chronic Pain: A Pilot RCT
Status: COMPLETED
Conditions: Chronic Pain
Interventions: BEHAVIORAL: Virtual Peer-to-Peer Support Mentoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Immunoadsorption Therapy for Patients With Non-Ischemic Dilated Cardiomyopathy (DCM)
Status: TERMINATED
Conditions: Cardiomyopathy, Dilated
Interventions: DEVICE: Mysorba
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of All-Stim 2 Quadriceps Treatments on Limb Muscle Strength In Mechanically Ventilated Patients
Status: TERMINATED
Conditions: Weakness
Interventions: DEVICE: Active electrical stimulation using an All Stim stimulator|DEVICE: Sham electrical stimulation using an All Stim stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: SGLT2 Inhibitors on Clinical Outcomes and Left Ventricular Remodeling in Type 2 Diabetic Patients With Acute Myocardial Infarction, a Prospective, Multi-center Registry Study
Status: RECRUITING
Conditions: Myocardial Infarction|Diabetes Mellitus, Type 2
Interventions: DRUG: SGLT2 inhibitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Molecular, Cytological Features and Genetic Susceptibility of COPD Attributable to Different Environmental Exposures
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: exposure to respirable silica dust|OTHER: exposure to polycyclic aromatic hydrocarbons exhaust
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: BPAP in Pediatric Asthma Pilot Study
Status: WITHDRAWN
Conditions: Asthma in Children|Status Asthmaticus
Interventions: DEVICE: Philips Respironics V60 Non-invasive ventilator, BPAP|OTHER: Standard Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Three Strategies of Second-line Antiretroviral Treatment in Africa (Dakar - Bobo-Dioulasso - Yaoundé)
Status: COMPLETED
Conditions: HIV|HIV Infections
Interventions: DRUG: emtricitabine/tenofovir + lopinavir/ritonavir (WHO recommended second line)|DRUG: abacavir + didanosine + lopinavir/ritonavir (WHO recommended second line)|DRUG: emtricitabine/tenofovir + darunavir + ritonavir (Second line strategy under evaluation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LUT014 for the Treatment of Radiation Induced Dermatitis in Breast Cancer Patients
Status: COMPLETED
Conditions: Radiation Dermatitis
Interventions: DRUG: LUT014 Gel|DRUG: Placebo for LUT014 Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Combination Therapy With VELCADE, Doxil, and Dexamethasone (VDd) in Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: VELCADE|DRUG: Doxil|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of TNX-102 SL in Participants With PTSD
Status: WITHDRAWN
Conditions: PTSD
Interventions: DRUG: TNX-102 SL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Predicting the Risk of Non-culprit Coronary Artery Disease After a Heart Attack
Status: RECRUITING
Conditions: Coronary Artery Disease|ST Elevation Myocardial Infarction|Ischemic Heart Disease
Interventions: DIAGNOSTIC_TEST: Optical coherence tomography and pressure wire assessment|DIAGNOSTIC_TEST: Cardiac magnetic resonance angiogram
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Characterization of [11C]Flumazenil to Image GABA Transmission in Healthy Adult Subjects and Subjects With Alcohol Dependence
Status: COMPLETED
Conditions: Alcoholism
Interventions: RADIATION: [11C]flumazenil|DRUG: Tiagabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE