pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: To Examine the Effects of Axitinib Dose Reduction and Interruption for Adverse Event Management Among Patients Receiving Axitinib in for the Treatment of Advanced Renal Cell Carcinoma
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Axitinib|DRUG: Avelumab|DRUG: Pembrolizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Genotype-driven Phase I Study of Irinotecan Administered in Neoadjuvant Chemoradiotherapy in Patients With Stage II/III Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: DRUG: Irinotecan|DRUG: Capecitabine|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imetelstat Given Intravenously Alone and With Standard 13-Cis-Retinoic Acid in Children With Neuroblastoma
Status: WITHDRAWN
Conditions: Neuroblastoma
Interventions: DRUG: Imetelstat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bilateral Ultrasound-Guided Intra Muscular Quadratus Lumborum Block Versus Trans Muscular Quadratus Lumborum Block for Peri-Operative Analgesia in Abdominal Surgeries in Pediatric Patients. A Comparative Controlled Randomized Study.
Status: COMPLETED
Conditions: Pain, Acute
Interventions: PROCEDURE: Bilateral Ultrasound-Guided Transmuscular Quadratus Lumborum Block.|PROCEDURE: Bilateral Ultrasound-Guided intra smuscular Quadratus Lumborum Block.|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Quality of Life After Ministernotomy Versus Full Sternotomy Aortic Valve Replacement
Status: COMPLETED
Conditions: Aortic Valve Stenosis|Heart Valve Diseases|Aortic Valve Disease
Interventions: PROCEDURE: ministernotomy|PROCEDURE: Full sternotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Inguinal Hernia Study Using Biodesign IHM
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: DEVICE: Biodesign IHM|DEVICE: Polypropylene mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preventive Intramuscular Phenylephrine in Elective Cesarean Section Under Spinal Anesthesia
Status: COMPLETED
Conditions: Elective Cesarean Section|Spinal Anesthesia
Interventions: DRUG: Phenylephrine|DRUG: Normal saline|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: St.Jude Medical Cardiac Lead Assessment Study
Status: COMPLETED
Conditions: Externalized Conductors|Visual Lead Anomalies|Electrical Dysfunction
Interventions: DEVICE: Implanted with one or more of the following SJM leads: Riata leads, RiataST leads, Durata leads, and QuickSite/QuickFlex leads
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Feasibility and Acceptability of Switching to E-cigarettes Among Cigarette Smokers Engaged in SUD Treatment
Status: RECRUITING
Conditions: Tobacco Dependence Caused by Cigarettes
Interventions: DEVICE: NJOY ACE commercial e-cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D Intake in Pregnancy to Prevent Recurrence of Gestational Diabetes
Status: UNKNOWN
Conditions: Vitamin D Intake in First Trimester and Incidence of Gestational Diabetes Recurrence
Interventions: DRUG: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: This Study Tests How Healthy Men Tolerate Different Doses of BI1015550. The Study Also Tests How BI 1015550 is Taken up by the Body
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1015550|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Carbohydrate-Protein Supplementation During Endurance Running
Status: COMPLETED
Conditions: Supplementation During Endurance Performance
Interventions: DIETARY_SUPPLEMENT: CHO, CHO-P, CHO-CHO, PLA|DIETARY_SUPPLEMENT: CHO-P, CHO-CHO, PLA, CHO|DIETARY_SUPPLEMENT: CHO-CHO, PLA, CHO, CHO-P|DIETARY_SUPPLEMENT: PLA, CHO, CHO-P, CHO-CHO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Clinical Trial to Evaluate Safety and Efficacy of Jalosome® Soothing Gel.
Status: RECRUITING
Conditions: Radiation-induced Dermatitis
Interventions: DEVICE: Jalosome® soothing gel|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Use of Focalin for Fatigue in Sarcoidosis
Status: COMPLETED
Conditions: Sarcoidosis
Interventions: DRUG: d-methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Lithium Therapy on Long COVID Symptoms
Status: COMPLETED
Conditions: Long COVID
Interventions: DRUG: Lithium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of ERAS on Postoperative Nausea and Vomiting After Sleeve
Status: RECRUITING
Conditions: Nausea and Vomiting, Postoperative
Interventions: OTHER: standard care protcol|OTHER: enhanced recovery protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess Adverse Events and Change of Masseter Muscle Prominence Using BOTOX Injections in Adult Participants
Status: RECRUITING
Conditions: Masseter Muscle Prominence
Interventions: DRUG: BOTOX|DRUG: Placebo for BOTOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Value of 18F-FCH PET in Localizing Parathyroid Lesions: Comparison With MIBI Scan.
Status: COMPLETED
Conditions: Parathyroid Diseases
Interventions: DRUG: 18F-choline PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate ABY-035 in Subjects With Moderate-to-severe Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: BIOLOGICAL: ABY-035|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy Plus Chemotherapy in Treating Patients With Metastatic or Locally Recurrent Stomach Cancer or Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer|Gastric Cancer
Interventions: BIOLOGICAL: G17DT Immunogen|DRUG: cisplatin|DRUG: fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prostate Artery Embolization Compared to Holmium Laser Enucleation of the Prostate for Benign Prostatic Hyperplasia
Status: UNKNOWN
Conditions: Benign Prostatic Hyperplasia
Interventions: DEVICE: Holmium laser enucleation of the prostate|PROCEDURE: Artery embolization of the prostate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study to Assess the Safety and Immunogenicity of ChAd63 ME-TRAP - MVA ME-TRAP Heterologous Prime-boost Vaccination Co-administered With EPI Vaccines in Gambian Infants
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: ChAd63 ME-TRAP / MVA ME-TRAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vitamin D Status in Patients With Severe Sepsis
Status: WITHDRAWN
Conditions: Sepsis|Severe Sepsis|End Organ Damage|Multi Organ Failure
Interventions: DRUG: vitamin D3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing Machine Guided VR Based Training With Educator Guided Training in Metaverse
Status: RECRUITING
Conditions: Advanced Cardiac Life Support|Virtual Reality|Serious Game
Interventions: OTHER: VR Based Training with Machine Guidance (MG Group)|OTHER: VR Based Training with Educator Guidance in Metaverse (EG Group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: PK/PD of Extended-infusion Meropenem, Piperacillin-tazobactam and Cefepime in the Early Phase of Septic Shock
Status: UNKNOWN
Conditions: Septic Shock
Interventions: DRUG: MEROPENEM|DRUG: PIPERACILLIN-TAZOBACTAM|DRUG: CEFEPIME
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Controlling And Lowering Blood Pressure With the MobiusHDTM Device
Status: TERMINATED
Conditions: Hypertension
Interventions: DEVICE: MobiusHD|OTHER: Sham Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fasting During Neoadjuvant Chemotherapy in Patient With Epithelial Ovarian Cancer
Status: RECRUITING
Conditions: Epithelial Ovarian Cancer
Interventions: BEHAVIORAL: Intermittent Fasting|DRUG: Neoadjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of the Novel Unloading Device "HEPHAISTOS" on Bone, Muscles and Vessels
Status: COMPLETED
Conditions: Muscle; Atrophy, General
Interventions: DEVICE: Hephaistos unloading orthosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Travoprost 0.004% / Timolol 0.5% Ophthalmic Solution|OTHER: Timolol Vehicle|DRUG: Latanoprost 0.005% Ophthalmic Solution (XALATAN)|DRUG: Timolol Maleate Ophthalmic Solution 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Observational Study to Assess Intravitreal Aflibercept Injections Used in a "Treat and Extend" Regimen in Treatment-naïve Wet Age-related Macular Degeneration Patients
Status: COMPLETED
Conditions: Wet Age-related Macular Degeneration
Interventions: DRUG: Aflibercept (Eylea, BAY86-5321)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Single Port Colic Laparoscopic Surgery
Status: COMPLETED
Conditions: Colonic Neoplasms|Crohn's Disease|Diverticulitis
Interventions: PROCEDURE: single port surgery|PROCEDURE: Multiport surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Efficacy & Safety of the INTERCEPT Blood System for RBCs in Complex Cardiac Surgery Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Anemia
Interventions: DEVICE: INTERCEPT|DEVICE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Growth Hormone in Decompensated Liver Cirrhosis
Status: RECRUITING
Conditions: Liver Cirrhosis|Fibrosis|End Stage Liver Disease|Digestive System Disease|Physiological Effect of Drugs|Growth Hormone Treatment|Sarcopenia
Interventions: DRUG: Growth Hormone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: G7 Acetabular System With Vivacit-E or Longevity Liner PMCF Study
Status: RECRUITING
Conditions: Total Hip Arthroplasty|Degenerative Joint Disease of Hip|Avascular Necrosis of Hip|Rheumatoid Arthritis of Hip|Osteoarthritis, Hip|Osteoarthritis of Hip|Fractures, Hip|Fracture of Hip
Interventions: DEVICE: Vivacit-E and Longevity (HXLPE) Liners
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resistive Inspiratory Manoeuvre as Airway Clearance Technique in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: OTHER: Autogenic drainage (AD)|OTHER: Resistive inspiratory manoeuvre (RIM)|OTHER: Resistive inspiratory manoeuvre+autogenic drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Microperimetry and Optical Coherence Tomography (OCT) in Idiopathic Epiretinal Membrane
Status: COMPLETED
Conditions: Epiretinal Membrane
Interventions: PROCEDURE: Epiretinal Membrane Surgical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Demonstrate Bioequivalence Between 6 x 2 mg Tablets of Perampanel and a Single 12 mg Tablet of Perampanel in Healthy Subjects
Status: COMPLETED
Conditions: Partial Onset Epilepsy
Interventions: DRUG: perampanel|DRUG: perampanel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mild Intraoperative Hyperventilation to Decrease Post-op. Shoulder Pain After LSG
Status: COMPLETED
Conditions: Laparoscopic Gastric Sleeve Surgery|ASA-I and II Risk Class Patients|Same Surgeon
Interventions: OTHER: mild intraoperative hyperventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Exposure and Safety Study of Kimyrsa in ABSSSI Patients
Status: COMPLETED
Conditions: Acute Bacterial Skin and Skin Structure Infection
Interventions: DRUG: Current Formulation of Oritavancin|DRUG: Kimyrsa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: M7824 in People With Recurrent Respiratory Papillomatosis
Status: COMPLETED
Conditions: Recurrent Respiratory Papillomatosis|Respiratory Papillomatosis|Laryngeal Papilloma, Recurrent|Human Papilloma Virus
Interventions: DRUG: M7824
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Sevoflurane, Isoflurane and Propofol During Cardiac Surgery
Status: COMPLETED
Conditions: Coronary Artery Disease|Mitral Valve Insufficiency|Aortic Valve Insufficiency
Interventions: DRUG: Propofol|DRUG: Isoflurane|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effect of Endotracheal Tube Plus STYLET Versus Endotracheal Tube Alone
Status: COMPLETED
Conditions: Intubation Complication|Critically Ill
Interventions: DEVICE: ENDOTRACHEAL TUBE + STYLET|DEVICE: ENDOTRACHEAL TUBE ALONE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: gp209-2M antigen|BIOLOGICAL: incomplete Freund's adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor|Melanoma|HNSCC|Sarcoma|Squamous Cell Carcinoma|NSCLC
Interventions: BIOLOGICAL: T3011|COMBINATION_PRODUCT: T3011 + pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b Study of OMP-305B83 Plus Paclitaxel in Subjects With Ovarian, Peritoneal or Fallopian Tube Cancer
Status: COMPLETED
Conditions: Cancer Ovaries|Cancer Peritoneal|Cancer, Fallopian Tube
Interventions: DRUG: OMP-305B83|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations.
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Tozorakimab|DRUG: Tozorakimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study on the Application of Virtual Augmented Reality Combined With Finder in Preoperative Anterolateral Thigh Flap Perforator Positioning
Status: RECRUITING
Conditions: Blood Vessel Perforation
Interventions: DIAGNOSTIC_TEST: Virtual Augmented Reality Combined With Finder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: EnligHTN IV Trial - Multicenter Sham-controlled RCT of Renal Denervation for Hypertension
Status: TERMINATED
Conditions: Hypertension
Interventions: DEVICE: EnligHTN Renal Denervation|PROCEDURE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Blinded Randomized Controlled Trial of Artificial Intelligence Guided Detection of Intracardiac Thrombus
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation
Interventions: OTHER: Automated detection of the intracardiac thrombus through deep learning|OTHER: Electrophysiologist judgment of the intracardiac thrombus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Appropriate Strategy of Surgical Treatment in Ischemic Diabetic Foot
Status: UNKNOWN
Conditions: Diabetic Foot|Ischemic Diabetic Foot Ulcer|Popliteal Artery Stenosis
Interventions: PROCEDURE: Wound treatment|PROCEDURE: Vascular intervention surgery|PROCEDURE: Tibial transverse transport surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Traumatic Neuroprotection and Epilepsy Prevention of Valproate Acid
Status: UNKNOWN
Conditions: Traumatic Brain Injury
Interventions: DRUG: valproate acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transitioning Emotionally and Academically to Middle School Successfully (TEAMSS)
Status: RECRUITING
Conditions: Anxiety Disorders
Interventions: BEHAVIORAL: Transitioning Emotionally and Academically to Middle School Successfully (TEAMSS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Inotuzumab Ozogamicin (CMC-544) Plus Rituximab In Diffuse Large B-Cell Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma, B-Cell
Interventions: DRUG: inotuzumab ozogamicin (CMC-544)|DRUG: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TARGETed Therapy Drug MONITOring in DIGestive Oncology
Status: RECRUITING
Conditions: Digestive Cancer|Metastatic Colorectal Cancer|Hepatocellular Carcinoma|GIST|Neuroendocrine Tumors
Interventions: OTHER: Blood sampling to build population pharmacokinetics model
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MEOPA Versus Local Anesthesia for Analgesia During Chorionic Villus Sampling.
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Oxygen/nitrous oxide equimolar mix|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiographic Assessment of Bone Gain Following Sinus Lifting With Simultaneous Implant Placement Using Crestal Approach With Membrane Control Technique for Bone Augmentation of Atrophied Maxillary Posterior Ridge
Status: NOT_YET_RECRUITING
Conditions: Implant Site Reaction|Maxillary Deficiency
Interventions: PROCEDURE: Dental implant with sinus lifting.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azacitidine and Etanercept in Treating Patients With Myelodysplastic Syndromes
Status: COMPLETED
Conditions: de Novo Myelodysplastic Syndromes|Previously Treated Myelodysplastic Syndromes|Secondary Myelodysplastic Syndromes
Interventions: DRUG: azacitidine|BIOLOGICAL: etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ischemia Reperfusion: Prostaglandins and Antioxidants
Status: COMPLETED
Conditions: Ischemic Reperfusion Injury
Interventions: DIETARY_SUPPLEMENT: Antioxidant|DRUG: Prostaglandin inhibitor (Ibuprophen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Role of Microbiome on Biological Therapy Efficacy in axSpA and RA
Status: UNKNOWN
Conditions: Axial Spondyloarthritis|Arthritis, Rheumatoid
Interventions: BIOLOGICAL: biological disease-modifying antirheumatic drugs (bDMARDs)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Safety and Efficacy of Gene Therapy Drug in the Treatment of Spinal Muscular Atrophy (SMA) Type 2 Patients
Status: RECRUITING
Conditions: SMA II
Interventions: GENETIC: GC101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerance of Nelfinavir (NFV) Given With Zidovudine (ZDV) and Lamivudine (3TC) in HIV-Positive Pregnant Women and Their Infants
Status: COMPLETED
Conditions: HIV Infections|Pregnancy
Interventions: DRUG: Nelfinavir mesylate|DRUG: Lamivudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of rESP Injection for the Treatment of Anemia in Chronic Renal Failure Patients With Hemodialysis
Status: UNKNOWN
Conditions: Chronic Renal Failure With Hemodialysis
Interventions: DRUG: Recombinant Human Erythropoiesis Injection (CHO cell)|DRUG: Recombinant Erythropoiesis Stimulating Protein Injection(CHO cell)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Suboptimal Responders to Adefovir Switching to Entecavir
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Entecavir|DRUG: Adefovir/Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TeleMonitoring to Improve Substance Use Disorder Treatment After Detoxification
Status: COMPLETED
Conditions: Enhanced Telephone Monitoring|Usual Care
Interventions: BEHAVIORAL: Enhanced Telephone Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Vaccine Therapy and IDO1 Inhibitor INCB024360 in Treating Patients With Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Who Are in Remission
Status: WITHDRAWN
Conditions: Recurrent Fallopian Tube Cancer|Recurrent Ovarian Epithelial Cancer|Recurrent Primary Peritoneal Cavity Cancer|Stage IA Fallopian Tube Cancer|Stage IA Ovarian Epithelial Cancer|Stage IA Primary Peritoneal Cavity Cancer|Stage IB Fallopian Tube Cancer|Stage IB Ovarian Epithelial Cancer|Stage IB Primary Peritoneal Cavity Cancer|Stage IC Fallopian Tube Cancer|Stage IC Ovarian Epithelial Cancer|Stage IC Primary Peritoneal Cavity Cancer|Stage IIA Fallopian Tube Cancer|Stage IIA Ovarian Epithelial Cancer|Stage IIA Primary Peritoneal Cavity Cancer|Stage IIB Fallopian Tube Cancer|Stage IIB Ovarian Epithelial Cancer|Stage IIB Primary Peritoneal Cavity Cancer|Stage IIC Fallopian Tube Cancer|Stage IIC Ovarian Epithelial Cancer|Stage IIC Primary Peritoneal Cavity Cancer|Stage IIIA Fallopian Tube Cancer|Stage IIIA Ovarian Epithelial Cancer|Stage IIIA Primary Peritoneal Cavity Cancer|Stage IIIB Fallopian Tube Cancer|Stage IIIB Ovarian Epithelial Cancer|Stage IIIB Primary Peritoneal Cavity Cancer|Stage IIIC Fallopian Tube Cancer|Stage IIIC Ovarian Epithelial Cancer|Stage IIIC Primary Peritoneal Cavity Cancer|Stage IV Fallopian Tube Cancer|Stage IV Ovarian Epithelial Cancer|Stage IV Primary Peritoneal Cavity Cancer
Interventions: BIOLOGICAL: ALVAC(2)-NY-ESO-1 (M)/TRICOM vaccine|DRUG: IDO1 inhibitor INCB024360|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Supplement to Target Ageing Mechanisms on Vascular Function (STAMINA)
Status: RECRUITING
Conditions: Healthy Aging|Vascular Dilation
Interventions: DIETARY_SUPPLEMENT: "NOVOS Core" supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: EPO906 Therapy in Patients With Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Neoplasms|Colonic Neoplasms
Interventions: DRUG: epothilone b
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Benefit of Lidocaine on the Prevention of the Risk of Post Endoscopic Retrograde Cholangio-pancreatography Pancreatitis.
Status: RECRUITING
Conditions: ERCP Surgery
Interventions: DRUG: Intravenous lidocaine administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of INCA 0186 in Subjects With Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumors|Squamous Cell Carcinoma of the Head and Neck (SCCHN)|Gastrointestinal (GI) Malignancies
Interventions: DRUG: INCA00186|DRUG: Retifanlimab|DRUG: INCB106385
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Care-oriented Practical Training on Nurses' Intensive and Critical Care Competency and HAIs Indicators
Status: COMPLETED
Conditions: Intensive Care Unit|Health Care Associated Infection|Patient-Centered Care|Competence
Interventions: BEHAVIORAL: Care-oriented Practical Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Prophylactic Sub-lay Non-absorbable Mesh Following Midline Laparotomy: PROMETHEUS (PROphylactic Mesh Trial Evaluation UltraSound)
Status: COMPLETED
Conditions: Incisional Hernia|Wound Infection
Interventions: PROCEDURE: positioning of polypropylene strips for prophylactic purposes in closing the middle laparotomies to prevent the incisional hernia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Botulinum Toxin for the Treatment of Depression
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: clostridium botulinum toxin type A neurotoxin complex|OTHER: 0.9% NaCl solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Effects of Repetitive, Low-Level Blast Exposure on Special Operations Forces Service Members
Status: COMPLETED
Conditions: Traumatic Brain Injury|Blast Injuries
Interventions: DIAGNOSTIC_TEST: 3T Connectome MRI|DIAGNOSTIC_TEST: 7 Tesla MRI|DIAGNOSTIC_TEST: TSPO PET|DIAGNOSTIC_TEST: Tau PET|DIAGNOSTIC_TEST: Cognitive and Behavioral Assessments|DIAGNOSTIC_TEST: Blood Biomarkers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate the Efficacy and Safety of Filgotinib in Participants With Active Ankylosing Spondylitis Who Have an Inadequate Response to Biologic Disease-Modifying Antirheumatic Drug Therapy
Status: WITHDRAWN
Conditions: Ankylosing Spondylitis
Interventions: DRUG: Filgotinib|DRUG: Placebo to Match Filgotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cocoa to Improve Walking Performance in Peripheral Artery Disease
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: DRUG: Cocoa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Induction Chemotherapy Using Paclitaxel, Carboplatin, CPT-11 With Pegfilgrastim
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: CPT-11|DRUG: Pegfilgrastim|RADIATION: Conformal radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Suaahara Impact Evaluation: End-line Survey
Status: COMPLETED
Conditions: Nutritional Stunting|Feeding Behavior
Interventions: BEHAVIORAL: Health and family planning|BEHAVIORAL: Nutrition|BEHAVIORAL: Agriculture and homestead food production|BEHAVIORAL: Water, sanitation, and hygiene
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Eccentric and Concentric Strength Training in Patients With Subacromial Impingement Syndrome
Status: COMPLETED
Conditions: Subacromial Impingement Syndrome
Interventions: OTHER: Eccentric training|OTHER: Concentric training|OTHER: Standard physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Rivoceranib Plus Paclitaxel in Patients With Gastrointestinal Stromal Tumor
Status: RECRUITING
Conditions: Gastrointestinal Stromal Tumors
Interventions: DRUG: Rivoceranib Mesylate, Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Desogestrel (DSG) and Corifollitropin(FSH-CTP) Alfa for Ovarian Stimulation in Donors
Status: WITHDRAWN
Conditions: Infertility
Interventions: DRUG: FSH-CTP + DESOGESTREL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HAIC Combined With TQB2450 and Anlotinib in Second-line Treatment of Advanced Hepatocellular Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: HAIC（Mitoxantrone+Raltitrexed）、anlotinib、TQB2450
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DAta-driven personaLIzation of a digitAl Health Solution to Support Family Caregivers of Children With Chronic Conditions
Status: NOT_YET_RECRUITING
Conditions: Obesity, Childhood
Interventions: COMBINATION_PRODUCT: ACDP® and Semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Efficacy and Safety of AK3280 in Patients With Idiopathic Pulmonary Fibrosis
Status: NOT_YET_RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: AK3280|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Deepithelialized Free Gingival Graft Versus Subpithelial Connective Tissue Graft With Tunneling Technique in Treating RT2 Gingival Recession
Status: UNKNOWN
Conditions: RT2 Gingival Recession
Interventions: PROCEDURE: tunneling technique with sub epithelial connective tissue graft or deepithelialized free gingival graft.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Study of SAR302503 in Intermediate-2 and High Risk Patients With Myelofibrosis
Status: COMPLETED
Conditions: Hematopoietic Neoplasm
Interventions: DRUG: SAR302503|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Vitamin D Dose and Genotype of the Binding Protein in Infants and Children
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Bioavailability Study of Synerx and Verelan PM 300 mg Verapamil HCl ER Capsules Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: verapamil controlled release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Arthroscopically Assisted Versus Open Surgical Reduction of the Hip in Patients With Irreducible DDH Before the Walking Age
Status: NOT_YET_RECRUITING
Conditions: Developmental Dysplasia of the Hip
Interventions: PROCEDURE: arthroscopically assisted|PROCEDURE: open surgical reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Efficacy of AXA1125 in NASH With Fibrosis
Status: UNKNOWN
Conditions: Non Alcoholic Steatohepatitis (NASH)
Interventions: DRUG: AXA1125|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Percussive Ventilation Therapy (MetaNeb ®) Compared With Mucolytic Agents for Atelectasis in the Mechanically Ventilated Pediatric Patient
Status: COMPLETED
Conditions: Atelectasis
Interventions: DEVICE: continuous high frequency oscillator (CHFO)|DRUG: Acetylcysteine|DRUG: dornase alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Gemcabene in Adults With FPLD
Status: COMPLETED
Conditions: Familial Partial Lipodystrophy|Hypertriglyceridemia|Fatty Liver|NASH - Nonalcoholic Steatohepatitis
Interventions: DRUG: 300mg Gemcabene|DRUG: 600mg Gemcabene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Clinical Effectiveness of the Delta Xtend Reverse Total Shoulder
Status: TERMINATED
Conditions: Cuff Tear Arthropathy|Osteoarthritis With Cuff Deficiency|Rheumatoid Arthritis|Post Traumatic Injury to Shoulder|Revision Surgery of a Failed Anatomic Shoulder Prosthesis
Interventions: DEVICE: Delta Xtend Reverse Total Shoulder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sunitinib Before and After Surgery in Treating Patients With Stage IV Kidney Cancer
Status: UNKNOWN
Conditions: Kidney Cancer
Interventions: DRUG: motexafin gadolinium|DRUG: sunitinib malate|GENETIC: comparative genomic hybridization|GENETIC: gene expression analysis|GENETIC: mutation analysis|GENETIC: polymorphism analysis|OTHER: immunohistochemistry staining method|OTHER: iodine I-124 girentuximab|OTHER: laboratory biomarker analysis|OTHER: pharmacological study|PROCEDURE: adjuvant therapy|PROCEDURE: neoadjuvant therapy|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Metformin for the Treatment of Microvascular Dysfunction After Gestational Diabetes
Status: NOT_YET_RECRUITING
Conditions: Gestational Diabetes
Interventions: DRUG: Metformin Hydrochloride|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Hydrogen Rich Water Intake on Acute Body Response and Following Recovery After 5 km Run in Untrained Men
Status: COMPLETED
Conditions: Athletic Performance|Muscle Fatigue|Oxidative Stress
Interventions: DIETARY_SUPPLEMENT: Hydrogen rich water|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Chinese Ocular Exercise on Visual Acuity and Ocular Accommodation in Myopic Teenager
Status: COMPLETED
Conditions: Myopia
Interventions: OTHER: Chinese ocular exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nucleophilic Defense Against PM Toxicity (NEAT Trial)
Status: COMPLETED
Conditions: Air Pollution Toxicity
Interventions: DIETARY_SUPPLEMENT: L-carnosine|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ablation vs Resection of Colorectal Cancer Liver Metastases
Status: RECRUITING
Conditions: Colorectal Cancer Metastatic
Interventions: PROCEDURE: Surgical resection|PROCEDURE: Thermal ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Clinical Retention of Glass Ionomer Sealants Placed With and Without Rubber Dam: a Comparative Analysis
Status: UNKNOWN
Conditions: Dental Caries in Children
Interventions: DEVICE: Fuji Triage|OTHER: isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Tegaserod in Relieving the Symptoms of Female Patients With Irritable Bowel Syndrome (IBS), Excluding Those With Predominant Diarrhea IBS
Status: COMPLETED
Conditions: IBS-C and IBS With Mixed Bowel Habits
Interventions: DRUG: Tegaserod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Androgel on Atherogenesis in Type 2 Diabetic Males With Hypogonadotrophic Hypogonadism
Status: TERMINATED
Conditions: Type 2 Diabetic Male With Hypogonadotrophic Hypogonadism
Interventions: DRUG: androgel|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Chest Tube Drainage System (Thopaz+) Versus Analog in Pediatric Patients
Status: RECRUITING
Conditions: Air Leakage
Interventions: DEVICE: Madela THOPAZ Digital Device|DEVICE: Atrium Analog Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Improving Grasp Function in People With Sensorimotor Impairments by Combining Electrical Stimulation With a Robotic Hand Orthosis
Status: RECRUITING
Conditions: Stroke|Spinal Cord Injuries|Traumatic Brain Injury
Interventions: DEVICE: SensoExo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of AT-527 in Healthy Subjects (R07496998)
Status: COMPLETED
Conditions: Healthy Volunteer Study
Interventions: DRUG: AT-527 Formulation 1|OTHER: Placebo Comparator|DRUG: AT-527 Formulation 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Irradiation of the Para-Aortic Lymph Nodes and Supraclavicular Lymph Nodes in Locally Advanced Uterine Cervical Cancer
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: RADIATION: Prophylactic Irradiation of the Para-Aortic Lymph Nodes and supraclavicular lymph nodes in Locally Advanced Uterine Cervical Cancer|RADIATION: Prophylactic Irradiation of the Para-Aortic Lymph Nodes and supraclavicular lymph nodes in Locally Advanced Uterine Cervical Cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and Microbiome Dynamics of SER-287 in Subjects With Mild-to-Moderate Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: SER-287|DRUG: Placebo|DRUG: Placebo Pre-Treat|DRUG: Vancomycin Pre-Treat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pirfenidone in Patients With Unclassifiable Progressive Fibrosing Interstitial Lung Disease
Status: COMPLETED
Conditions: Lung Diseases, Interstitial
Interventions: DRUG: Pirfenidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of and Immune Response to a DNA HIV Vaccine Followed by an Adenoviral Vaccine Boost Given Three Different Ways to HIV Uninfected Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: VRC-HIVDNA009-00-VP|BIOLOGICAL: VRC-HIVADV014-00-VP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sequential Intrathecal Injection of Fentanyl and Hyperbaric Bupivacaine
Status: COMPLETED
Conditions: Elective Caesarean Section
Interventions: PROCEDURE: sequential intrathecal injection|DRUG: hyperbaric bupivacaine|DRUG: fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Open-label Phase 3 BTK Inhibitor Ibrutinib vs Chlorambucil Patients 65 Years or Older With Treatment-naive CLL or SLL
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Ibrutinib|DRUG: Chlorambucil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studying Partial-agonists for Ethanol and Tobacco Elimination in Russians With HIV (St PETER HIV)
Status: COMPLETED
Conditions: HIV Infection|Alcohol Use|Smoking
Interventions: DRUG: Varenicline|DRUG: Cytisine|DRUG: Nicotine Replacement Therapy|DRUG: Varenicline Placebo|DRUG: Cytisine Placebo|DRUG: Nicotine Replacement Therapy Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phone-based Smoking Cessation Intervention for Patients With Chronic Pancreatitis.(START)
Status: NOT_YET_RECRUITING
Conditions: Pancreatitis, Chronic
Interventions: BEHAVIORAL: Phone-based smoking cessation intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Automated Structured Education Based on an App and AI in Chinese Patients With Type 1 Diabetes
Status: UNKNOWN
Conditions: Type 1 Diabetes
Interventions: BEHAVIORAL: Automated structured education intervention based on an app and artificial intelligence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peroperative Assessment of Malignancies of the Head and Neck Using High-resolution 18F-FDG-PET/CT
Status: COMPLETED
Conditions: Head and Neck Neoplasms|Thyroid Neoplasm|Skin Neoplasm
Interventions: DIAGNOSTIC_TEST: high-resolution PET-CT specimen imaging.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC