pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Potential Impact of Cigarette Smoking on Platelet Reactivity in Patients on Dual Antiplatelet Therapy With P2Y12 Inhibitors
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: OTHER: quit smoking for a 2 weeks period
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Double-Blind Randomized Controlled Trial for the Evaluation of a Novel Adaptive Attention Training in Healthy Adolescents
Status: COMPLETED
Conditions: Healthy Adolescents
Interventions: BEHAVIORAL: Adaptive Attention Training|BEHAVIORAL: Active Control|BEHAVIORAL: Low-dose Adaptive Attention Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Glucocorticoid Antagonist Treatment for Tobacco Use Disorder
Status: TERMINATED
Conditions: Nicotine Dependence
Interventions: DRUG: Mifepristone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Community Versus Facility-based Services to Improve the Screening of Active HCV Infection in Cambodia
Status: UNKNOWN
Conditions: Hepatitis C|Testing
Interventions: OTHER: Community-based HCV rapid test|OTHER: Facility-based HCV rapid test|OTHER: Plasmatic HCV viral load|OTHER: DBS HCV viral load
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Enhancing the Therapeutic Efficacy of Sleep Deprivation by Modafinil
Status: WITHDRAWN
Conditions: Depression
Interventions: DRUG: Modafinil (Vigil)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intrathecal Bupivacaine-fentanyl and Bupivacaine-dexmedetomidine for Elective Low Segment Caesarean Section
Status: COMPLETED
Conditions: Cesarean Section Complications
Interventions: DRUG: Bupivacaine, fentanyl|DRUG: Bupivacaine, dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Avatrombopag for Treating TCP in HBV-ACLF Patients Receiving ALSS Treatment
Status: RECRUITING
Conditions: Thrombocytopenia|Hepatitis B, Chronic|Acute-On-Chronic Liver Failure
Interventions: DRUG: Avatrombopag|OTHER: Artificial Liver Support System|OTHER: Comprehensive internal medical treatment.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Progressive Relaxation Exercises on Sleep Quality and Fatigue in Postmenopausal Period
Status: COMPLETED
Conditions: Postmenopausal Period|Fatigue|Sleep Quality
Interventions: BEHAVIORAL: progressive relaxation exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Remote Game-based Exercise Program for Cognitive and Motor Function Improvement
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Dementia|Cognitive Impairment|Memory Loss
Interventions: DEVICE: Tele-Exergame Platform|DEVICE: No Tele-Exergame Platform
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea
Status: RECRUITING
Conditions: Rosacea
Interventions: DRUG: Imipramine|DRUG: Amitriptyline|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Blocks for Adolescent Idiopathic Scoliosis
Status: ENROLLING_BY_INVITATION
Conditions: Pain, Postoperative|Opioid Use|Recruitment
Interventions: PROCEDURE: Bilateral Erector Spinae Plane Block with bupivacaine and dexamethasone|OTHER: No bilateral Erector Spinae Plane Block (no bupivacaine and no dexamethasone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Outcome of the Thrombopoietin Receptor Agonists in Pediatric Patient With Persistent or Chronic ITP Unresonsive to Steroids
Status: RECRUITING
Conditions: Persistent or Chronic ITP Not Respnding to Steroids
Interventions: DIAGNOSTIC_TEST: CBC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Feasibility, Safety, Initial Efficacy and Clinical Usability of FuseX Anti-Adhesion System
Status: COMPLETED
Conditions: Reduction of Postoperative Adhesions
Interventions: PROCEDURE: Concentrate of plasma coagulation factors|PROCEDURE: 0.9% saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Safety of Nivolumab in the Treatment of Metastatic Melanoma, Lung Cancer, Renal Cancer, Squamous Cell Carcinoma of the Head and Neck, and Chronic Hodgkin Lymphoma in Adults in Mexico
Status: WITHDRAWN
Conditions: Multiple Indications Cancer
Interventions: OTHER: Non-Interventional
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Powered Knee-Ankle Prosthesis Leg on Everyday Community Mobility and Social Interaction
Status: ACTIVE_NOT_RECRUITING
Conditions: Transfemoral Amputees
Interventions: DEVICE: Vanderbilt Powered Knee-Ankle Prosthesis|DEVICE: Microprocessor (MP) Knee Prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Acupuncture Treatment of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation
Status: COMPLETED
Conditions: COPD Exacerbation
Interventions: OTHER: Acupuncture|OTHER: Sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Acupressure-Ice Message on Primary Dysmenorrhea
Status: NOT_YET_RECRUITING
Conditions: Primary Dysmenorrhea
Interventions: OTHER: acupressure ice massage|OTHER: pelvic rocking exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cilostazol-Simvastatin Drug Interaction Study
Status: UNKNOWN
Conditions: Dyslipidemias|Peripheral Artery Disease
Interventions: DRUG: Simvastatin|DRUG: Pravastatin|DRUG: Cilostazol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Knack Technique in Post-menopausal Women With Stress Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence,Stress
Interventions: OTHER: knack technique.|OTHER: pelvic floor muscle exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of Copanlisib to Eribulin for the Treatment of Advanced-Stage Triple Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Triple-Negative Breast Carcinoma|Unresectable Triple-Negative Breast Carcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Copanlisib Hydrochloride|DRUG: Eribulin Mesylate|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Ranibizumab and Verteporfin Therapy in Neovascular Age-related Macular Degeneration
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: PEP005 Gel - Biological Effects in Actinic Keratosis Assessed by Reflectance Confocal Microscopy
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Ingenol mebutate|DRUG: Placebo Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Acceptability of Active Monitoring (AM) as a Treatment Option for Ductal Carcinoma in Situ (DCIS)
Status: COMPLETED
Conditions: Ductal Carcinoma in Situ
Interventions: BEHAVIORAL: Decision Support Tool with Active Monitoring|BEHAVIORAL: Decision Support Tool without Active Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Empagliflozin (BI 10773) Versus Placebo and Sitagliptin Over 24 Weeks in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo identical to BI10773 high dose|DRUG: BI 10773|DRUG: BI 10773 open label|DRUG: Placebo identical to BI10773 low dose|DRUG: Placebo identical to BI10773 low dose|DRUG: Placebo identical to BI10773 high dose|DRUG: Placebo identical to Sitagliptin 100mg|DRUG: Placebo identical to Sitagliptin 100mg|DRUG: BI10773|DRUG: Sitagliptin|DRUG: Placebo identical to Sitagliptin 100mg|DRUG: Placebo identical to BI10773 low dose|DRUG: Placebo identical to BI10773 high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: FOLFOX6 Totally Neoadjuvant Chemoradiation Therapy in Locally Advanced Rectal Cancer: A Real World Study
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: DRUG: mFOLFOX6|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VRC 208: Dose, Safety and Immunogenicity of a Recombinant Modified Vaccinia Virus Ankara Ebola Vaccine, VRC-EBOMVA079-00-VP (MVA-EbolaZ), Administered Alone or as a Boost to cAd3-Ebola Vaccines in Healthy Adults
Status: COMPLETED
Conditions: Healthy Adult Immune Responses to Vaccine
Interventions: BIOLOGICAL: VRC-EBOMVA079-00-VP (MVA-EbolaZ)|BIOLOGICAL: VRC-EBOADC069-00-VP (cAd3-EBO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Investigation of Long-term Effects of CarelessTM on Microcirculation
Status: COMPLETED
Conditions: Disorder of Circulatory System|Metabolic Disease
Interventions: DIETARY_SUPPLEMENT: Mango fruit powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Chinese Medicinal Herbs Treatment on Novel Influenza A (H1N1)Pneumonia: Multi-centre, Prospective, Randomized Controlled Study
Status: UNKNOWN
Conditions: Influenza
Interventions: DRUG: oseltamivir|DRUG: oseltamivir and chinese medicinal herbs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Online Pulmonary Rehabilitation 'myPR' Versus Conventional Pulmonary Rehabilitation for Patients With COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Diseases
Interventions: BEHAVIORAL: Face to Face Pulmonary Rehabilitaton|BEHAVIORAL: Online Pulmonary Rehab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: CX-5461
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retroclavicular Versus Supraclavicular Brachial Plexus Block for Hand and Forearm Surgery
Status: COMPLETED
Conditions: Hand Injury
Interventions: PROCEDURE: retroclavicular block|PROCEDURE: supraclavicular block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Iron Supplementation for Patients With Chronic Kidney Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Renal Disease|Iron-Deficiency Anemia|Anemia of Chronic Kidney Disease|Dysbiosis
Interventions: DRUG: Ferrous sulfate 3 days week|DRUG: Ferrous sulfate daily|DRUG: Ferrous sulfate higher concentration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Olfactive Stimulation Interventions With Mothers' Milk on Preterm Pain Response
Status: UNKNOWN
Conditions: Pain, Acute|Preterm Infant|Breast Milk
Interventions: OTHER: Olfactive stimulation intervention with familiarization|OTHER: Olfactive stimulation intervention|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Evolution of Gastric Emptying by Gastric Ultra Sonography in Patients Treated With GLP-1 Receptor Agonists on a 7 Days Pausing Period.
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 2|Anesthesia|Pulmonary Aspiration of Gastric Contents
Interventions: DEVICE: Gastric Ultrasonography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Persistency Study After aP / Tdap Booster Vaccines in Adult Subjects (V113_01 Extension 1)
Status: COMPLETED
Conditions: Pertussis
Interventions: BIOLOGICAL: aP booster|BIOLOGICAL: TdaP booster|BIOLOGICAL: Licensed TdaP booster (Boostrix®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Bone Flap Osteomyelitis Following Craniectomy : Retrospective Evaluation of Clinical Presentation, Microbiological Diagnosis and Management
Status: UNKNOWN
Conditions: Osteitis|Cranial Flap
Interventions: OTHER: patients having had an osteitis of the cranial flap after craniectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Iodine I 131 and Pazopanib Hydrochloride in Treating Patients With Recurrent and/or Metastatic Thyroid Cancer Previously Treated With Iodine I 131 That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Recurrent Thyroid Cancer|Stage IVA Follicular Thyroid Cancer|Stage IVA Papillary Thyroid Cancer|Stage IVB Follicular Thyroid Cancer|Stage IVB Papillary Thyroid Cancer|Stage IVC Follicular Thyroid Cancer|Stage IVC Papillary Thyroid Cancer
Interventions: DRUG: pazopanib hydrochloride|RADIATION: iodine I 131
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GFRα4 CAR T Cells in MTC Patients
Status: RECRUITING
Conditions: Metastatic Medullary Thyroid Cancer
Interventions: DRUG: single dose of CART-GFRa4 cells|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The COMparison of CALcium Bioavailability Between AlgaeCal® and a Proprietary Supplement
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: AlgaeCal|DIETARY_SUPPLEMENT: Caltrate 600
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Adipose Tissue Dysfunction in Type 2 Diabetes and Its Reversibility by Bariatric Surgery
Status: UNKNOWN
Conditions: Adipose Tissue Dysfunction Type 2 Diabetes Mellitus Bariatric Surgery
Interventions: PROCEDURE: Gastric byspass
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study of ASP8273 in Subjects With Non-Small-Cell Lung Cancer (NSCLC) Who Have Epidermal Growth Factor Receptor (EGFR) Mutations
Status: COMPLETED
Conditions: Non-Small-Cell Lung Cancer (NSCLC)|Epidermal Growth Factor Receptor Mutations
Interventions: DRUG: naquotinib|DRUG: midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid in Pediatric Undergoing Proximal Femoral Osteotomies and/or Acetabular Osteotomy
Status: UNKNOWN
Conditions: Intraoperative Blood Loss|Pediatric|Orthopedic Disorder
Interventions: DRUG: Tranexamic acid|PROCEDURE: caudal epidural block|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness and Safety of ArcBlate Palliative Treatment for Patients With Painful Bone Metastases: A Pivotal Study
Status: RECRUITING
Conditions: Bone Metastases
Interventions: DEVICE: ArcBlate Focused Ultrasound Ablation System|OTHER: Sham MRgHIFU treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Uracyst to Treat Interstitial Cystitis/Painful Bladder Syndrome
Status: COMPLETED
Conditions: Interstitial Cystitis|Painful Bladder Syndrome
Interventions: DRUG: 2% sodium chondroitin sulfate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of HPP854 in Subjects With Mild Cognitive Impairment or a Diagnosis of Mild Alzheimer's Disease
Status: TERMINATED
Conditions: Mild Alzheimer's Disease|Mild Cognitive Impairment
Interventions: DRUG: HPP854|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Obesity Hypoventilation Syndrome on Exercise Capacity, Peripheral Muscle Strength, and Quality of Life in Obese Individuals
Status: NOT_YET_RECRUITING
Conditions: Obesity Hypoventilation Syndrome|Obesity|Hypoventilation|Respiration Disorders|Sleep Disorder; Breathing-Related
Interventions: OTHER: Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prediction of Recurrence Among Low Risk Endometrial Cancer Patients
Status: RECRUITING
Conditions: FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma|FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma
Interventions: PROCEDURE: Bilateral Salpingectomy with Oophorectomy|PROCEDURE: Biospecimen Collection|PROCEDURE: Hysterectomy|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Lymph Node Mapping|PROCEDURE: Sentinel Lymph Node Biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Natural History Study for Pediatric Patients With Early Onset of Either GM1 Gangliosidosis, GM2 Gangliosidoses, or Gaucher Disease Type 2
Status: COMPLETED
Conditions: GM1 Gangliosidosis|GM2 Gangliosidosis|Gaucher Disease, Type 2|Tay-Sachs Disease|AB Variant Gangliosidosis GM2|Sandhoff Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tai Chi Versus Conventional Exercise to Improve Cognitive Performance in Older Adults With Mild Cognitive Impairment
Status: RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Health Education|BEHAVIORAL: Conventional Exercise|BEHAVIORAL: Tai Chi
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Raltitrexed and Paclitaxel for Gastric or Gastroesophageal Junction Adenocarcinoma
Status: COMPLETED
Conditions: Gastric Cancer|Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Raltitrexed|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probing the Cannabinoid System in Individuals With a Family History of Psychosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Psychosis|Cannabis Use|THC|Marijuana|Schizophrenia
Interventions: DRUG: Placebo|DRUG: Very Low Dose THC|DRUG: Low Dose THC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Study to Determine Efficacy of Probiotics in Irritable Bowel Syndrome
Status: WITHDRAWN
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Probiotic VSL#3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extended Access of Momelotinib in Adults With Myelofibrosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Neoplasms|Post-polycythemia Vera Myelofibrosis (Post-PV MF)|Primary Myelofibrosis (PMF)|Post-essential Thrombocythemia Myelofibrosis (Post-ET MF)
Interventions: DRUG: MMB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Antiviral Therapies on Epstein-Barr Virus Replication
Status: ENROLLING_BY_INVITATION
Conditions: Multiple Sclerosis
Interventions: DRUG: Truvada (tenofovir/emtricitabine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Characterization of Transient Alterations of Cutaneous Sensory Nerve Function by Cryolipolysis
Status: COMPLETED
Conditions: Adiposity
Interventions: DEVICE: Zeltiq CoolSculpting device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PRospective Study to Measure the Impact of MammaPrint on Adjuvant Treatment in Hormone Receptor-positive HER2-negative Breast Cancer Patients (PRIMe)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: MammaPrint|OTHER: BluePrint|OTHER: TargetPrint
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Clofarabine in Japanese Paediatric Patients With Relapsed or Refractory Acute Lymphoblastic Leukaemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ABT-263 When Administered in Combination With Either Fludarabine/Cyclophosphamide/Rituximab or Bendamustine/Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: ABT-263|DRUG: FCR|DRUG: BR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preliminary Investigation of Novel Methods to Reduce Children's Secondhand Smoke Exposure
Status: COMPLETED
Conditions: Secondhand Smoke
Interventions: DRUG: Nicotine polacrilex|DRUG: Electronic Cigarette|DRUG: Dissolvable Tobacco Lozenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse
Status: RECRUITING
Conditions: Aging|Oxidative Stress|Vascular Endothelium|Skeletal Muscle|Antioxidants
Interventions: DIETARY_SUPPLEMENT: MITO-AO|DIETARY_SUPPLEMENT: PB-125|OTHER: Placebo|OTHER: Passive Leg Movement (PLM)|OTHER: Plantar flexion|OTHER: Isometric knee extensor test|OTHER: Bed rest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: PRINCE22 System Complete Performance Study
Status: COMPLETED
Conditions: Hearing Loss, Bilateral|Hearing Loss, Unilateral
Interventions: DEVICE: Measures of speech intelligibility in a noisy situation with speech from the side and from behind (measured with CC-OLSA Test)|DEVICE: Measures of the subjective speech recognition threshold in a noisy situation with speech from the side and from behind (measured with HEISS test)|DEVICE: Ability to multitask in the auditory and visual domains in noisy situation with speech from the side and from behind (Multitask test)|DEVICE: Measure of subjective speech intelligibility and listening effort in noisy situation with speech from the side and from behind (subjective assessment; 100-point scale)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Citrulline Supplementation On Vascular Responsiveness and Function in Postmenopausal Women
Status: COMPLETED
Conditions: Menopause
Interventions: DIETARY_SUPPLEMENT: L-Citrulline|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Post Operative Adjuvant Therapy De-intensification Trial for Human Papillomavirus-related, p16+ Oropharynx Cancer
Status: TERMINATED
Conditions: Oropharyngeal Neoplasms
Interventions: RADIATION: Intensity-modulated radiation therapy (IMRT)|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lot-to-lot Consistency of an Inactivated SARS-CoV-2 Vaccine Between Different Workshops in Healthy Children Aged 3-17 Years
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: Inactivated SARS-CoV-2 Vaccine (Vero cell) Lot 1 of the workshop 2|BIOLOGICAL: Inactivated SARS-CoV-2 Vaccine (Vero cell) Lot 2 of the workshop 2|BIOLOGICAL: Inactivated SARS-CoV-2 Vaccine (Vero cell) Lot 3 of the workshop 2|BIOLOGICAL: Inactivated SARS-CoV-2 Vaccine (Vero cell) Lot 1 of the workshop 3|BIOLOGICAL: Inactivated SARS-CoV-2 Vaccine (Vero cell) Lot 2 of the workshop 3|BIOLOGICAL: Inactivated SARS-CoV-2 Vaccine (Vero cell) Lot 3 of the workshop 3|BIOLOGICAL: Inactivated SARS-CoV-2 Vaccine (Vero cell) Lot 1 of the workshop 1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Dietary Fibers Effect on the Gut Microbiota Composition
Status: WITHDRAWN
Conditions: Microbiome|Metabolic Syndrome|Cardiovascular Risk Factor|Inflammation|Dyslipidemias
Interventions: DIETARY_SUPPLEMENT: Maltodextrin|DIETARY_SUPPLEMENT: Inulin|DIETARY_SUPPLEMENT: Pectin|DIETARY_SUPPLEMENT: Beta-glucan|DIETARY_SUPPLEMENT: Galactooligosaccharides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Intercostal Nerve Block With Ropivacaine Combined With Mecobalamine on Chronic Pain After Thoracic Surgery
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: PROCEDURE: Intercostal nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Effects of Cognitive and Motor Dual Task Training on Balance and Quality Of Life in Parkinson's Patients
Status: COMPLETED
Conditions: Parkinson Disease|Balance; Distorted|Postural; Defect
Interventions: OTHER: cognitive training and conventional training|OTHER: motor dual task training along with conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Parent Training With Role-plays in Virtual Reality for Parents of Children With Behavior Problems
Status: NOT_YET_RECRUITING
Conditions: Child Behavior Problem|Disruptive Behavior|Oppositional Defiant Disorder|Conduct Problems|Aggression|Parent-Child Relations
Interventions: BEHAVIORAL: Step-by-step: A cognitive behavioral parent program with role-plays in virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Neuromodulators in Refractory Functional Dyspepsia
Status: UNKNOWN
Conditions: Dyspepsia|Functional Gastrointestinal Disorders|Antidepressant Discontinuation Syndrome|Antidepressant Drug Adverse Reaction
Interventions: DRUG: Deanxit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 99mTc-anti-TNF-alpha Scintigraphy in the Evaluation of Inflammatory Processes Activity
Status: UNKNOWN
Conditions: Psoriatic Arthritis|Arthritis
Interventions: OTHER: 99mTc-anti-TNF-alpha Scintigraphy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine Models
Status: RECRUITING
Conditions: Idiopathic CD4-Positive|T-Lymphocytopenia
Interventions: BIOLOGICAL: Filgrastim|DRUG: Plerixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Custodiol-N Solution Compared With Custodiol Solution in Organ Transplantation (Kidney, Liver and Pancreas)
Status: RECRUITING
Conditions: Kidney Failure|Liver Failure, Chronic|Kidney-Pancreas Failure
Interventions: DRUG: Custodiol-N Solution|DRUG: Custodiol HTK Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Dose Study of HU6 in High BMI Volunteers
Status: COMPLETED
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: DRUG: HU6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hormonal Therapy and Chemotherapy Followed by Prostatectomy in Patients With Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Degarelix|DRUG: Doxorubicin|DRUG: Ketoconazole|DRUG: Docetaxel|DRUG: Estramustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of the Akreos Toric Intraocular Lens.
Status: COMPLETED
Conditions: Cataract|Astigmatism
Interventions: DEVICE: Akreos Toric IOL|DEVICE: Akreos Advanced Optics Aspheric Intraocular Lens (Akreos AO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Humidified Forest Oils for Immune System Recovery in Stage I-III Breast or Prostate Cancer
Status: ENROLLING_BY_INVITATION
Conditions: Breast Carcinoma|Prostate Carcinoma
Interventions: OTHER: Aromatherapy with Essential Oils
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Composite Outcomes of Mesh vs Suture Techniques for Prolapse Repair: A Randomized Controlled Multicentre Trial
Status: RECRUITING
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: SSLS Procedure|PROCEDURE: BSSVF-M Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ASP2215 in Combination With Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Gilteritinib|DRUG: Idarubicin|DRUG: Cytarabine|DRUG: Daunorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of Vorinostat and Bortezomib in Multiple Myeloma (MK-0683-015 EXT 1 (AM1))
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: vorinostat|DRUG: bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studying Genes in Samples From Younger Patients With Acute Lymphoblastic Leukemia
Status: UNKNOWN
Conditions: Leukemia
Interventions: GENETIC: DNA analysis|GENETIC: fluorescence in situ hybridization|GENETIC: gene expression analysis|GENETIC: microarray analysis|GENETIC: mutation analysis|GENETIC: polymorphism analysis|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluate the Efficacy and Safety of Diclofenac Diethylamine 2.32% Gel Applied Twice or Three Times Daily in Patients With Acute Ankle Sprain
Status: COMPLETED
Conditions: Grade I/II Ankle Sprain
Interventions: DRUG: diclofenac diethylamine gel 2.32%|DRUG: diclofenac diethylamine gel 2.32%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Long-term Peg Intron vs. Colchicine in Non-responders.
Status: COMPLETED
Conditions: Hepatitis C Virus|Advanced Fibrosis|Cirrhosis
Interventions: DRUG: PEG -Intron|DRUG: Colchicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Comparing Acne in Patients Taking Oral Minocycline to Patients Taking Minocycline Plus Topical Tretinoin
Status: TERMINATED
Conditions: Acne Vulgaris
Interventions: DRUG: Minocycline|DRUG: Minocycline plus tretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Two Anti-HIV Combination Therapies Each Containing Saquinavir in HIV-Positive Children
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Ritonavir|DRUG: Nelfinavir mesylate|DRUG: Saquinavir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effects of CSL324 in the Lung After Segmental Challenge
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: CSL324|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Simvastatin and Metformin Therapy in PCOS Women. Prospective Randomised Trial.
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Simvastatin|DRUG: Simvastatin and Metformin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study To Evaluate The Safety And Efficacy of PBCLN-010 In Combination With PBCLN-014 in Participants Receiving Allogeneic Hematopoietic Cell Transplantation
Status: TERMINATED
Conditions: Hematologic Malignancy
Interventions: DRUG: B. infantis (PBCLN-014) and Human Milk Oligosaccharides (HMO) (PBCLN-010)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vapocoolant Spray for Reducing the Pain of Spinal Needle Insertion
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DEVICE: vapocoolant spray|DRUG: local infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Post-Marketing Clinical Study of Aricept in Patients With Dementia With Lewy Bodies (DLB)
Status: COMPLETED
Conditions: Dementia, Lewy Body|Lewy Body Disease
Interventions: DRUG: E2020|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vorinostat and Bortezomib in Treating Patients With Metastatic or Unresectable Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: bortezomib|DRUG: vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing of the Pharmacokinetic, Pharmacodynamic, Safety and Immunogenicity of MW031 and Prolia® in Healthy Adults
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal
Interventions: DRUG: MW031|DRUG: Prolia®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Transcranial Direct Current Stimulation (tDCS) on Language
Status: RECRUITING
Conditions: Stroke|Aphasia
Interventions: DEVICE: Targeted Transcranial Direct Current Stimulation|DEVICE: Active Control Transcranial Direct Current Stimulation|BEHAVIORAL: Phonologic-Focused Speech Therapy|BEHAVIORAL: Semantic-Focused Speech Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Assessing the Feasibility, Safety and Efficacy of Genetically Engineered Glucocorticoid Receptor Knock Out Virus Specific CTL Lines for Viral Infections in Immunosuppressed Cancer Patients
Status: RECRUITING
Conditions: Adenovirus Infection|BK Virus Infection|Cytomegaloviral Infection|Hematopoietic and Lymphoid Cell Neoplasm|JC Virus Infection|Malignant Solid Neoplasm|Symptomatic COVID-19 Infection Laboratory-Confirmed
Interventions: BIOLOGICAL: Virus-specific Cytotoxic T-lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18-F Sodium Fluoride (18F-NaF) PET for the Assessment of Bioprosthetic Aortic Valve Durability and Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Stenosis
Interventions: OTHER: 18F-NaF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: When to Perform Bladder Catheterization in Fast-track Hip and Knee Arthroplasty
Status: COMPLETED
Conditions: Postoperative Urinary Retention (POUR)
Interventions: PROCEDURE: increased interventional threshold for urinary bladder catheterization (800 ml)|PROCEDURE: Current used interventional threshold for urinary bladder catheterization (500 ml)|DEVICE: Intermittent bladder catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Lanolin and Breastmilk in the Treatment of Sore and Damaged Nipples in Breastfeeding Women
Status: COMPLETED
Conditions: Breastfeeding
Interventions: DRUG: Lanolin|OTHER: Mother's milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Cumulative Skin Irritation Potential of a New 15 mg Nicotine Patch
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Nicotine Patch|DRUG: Nicotine Patch Comparator|DRUG: Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: A Phase II Study of Tivozanib in Patients With Metastatic and Non-resectable Soft Tissue Sarcomas
Status: COMPLETED
Conditions: Recurrent Adult Soft Tissue Sarcoma|Stage III Adult Soft Tissue Sarcoma|Stage IV Adult Soft Tissue Sarcoma
Interventions: DRUG: tivozanib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COOL AMI EU Pivotal Trial to Assess Cooling as an Adjunctive Therapy to PCI In Patients With Acute MI (Phase A)
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DEVICE: Intravascular permissive hypothermia as an adjunct to PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Passive Ultrasonic Irrigation on Success of Primary Endodontic Treatment
Status: COMPLETED
Conditions: Periapical Periodontitis
Interventions: DEVICE: Proultra PiezoFlow (Dentsply Tulsa Dental Specialties)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of High Frequency rTMS Combined Motor Learning on Upper Limb Motor Function in Subacute Stroke
Status: COMPLETED
Conditions: Stroke, Acute|Hemiplegia
Interventions: DEVICE: HF-rTMS|BEHAVIORAL: ML|DEVICE: Sham-rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bronchopulmonary Dysplasia: From Neonatal Chronic Lung Disease to Early Onset Adult COPD
Status: COMPLETED
Conditions: Bronchopulmonary Dysplasia|Preterm Birth
Interventions: OTHER: Hyperpolarized Xenon-129
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Thalidomide With or Without Probiotics in Radioactive Oral Mucositis
Status: UNKNOWN
Conditions: Oral Mucositis|Quality of Life
Interventions: OTHER: probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CLEANer Aspiration for Pulmonary Embolism
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Embolism|Acute Pulmonary Embolism|Cardiovascular Diseases|Venous Thromboembolism
Interventions: DEVICE: Cleaner Pro Thrombectomy System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Safety, Absorption and Metabolism of SYHA1402 Tablets in Healthy People
Status: COMPLETED
Conditions: Diabetic Neuropathy Peripheral
Interventions: DRUG: 25mg|DRUG: 50mg|DRUG: 100mg|DRUG: 200mg|DRUG: 400mg|DRUG: 800mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of Sorafenib and Irinotecan Combination Therapy in Pediatric Patients With Solid Tumors
Status: COMPLETED
Conditions: Rhabdomyosarcoma and Other Soft Tissue Sarcomas|Ewing's Sarcoma Family of Tumors|Osteosarcoma|Neuroblastoma|Brain Tumors
Interventions: DRUG: sorafenib|DRUG: irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study Evaluating Efficacy, Safety and Tolerability of Different Doses and Regimens of Allocetra-OTS for the Treatment of Organ Failure in Adult Sepsis Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Sepsis|Community-acquired Pneumonia|Urinary Tract Infections|Cholecystitis, Acute|Cholangitis Acute|Intraabdominal Infections
Interventions: DRUG: Allocetra-OTS|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intensity Modulated Total Marrow Irradiation (IM-TMI) for Advanced Hematologic Malignancies
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Lymphoblastic Leukemia|Acute Leukemia|Non Hodgkins Lymphoma|Chronic Myeloid Leukemia
Interventions: RADIATION: IM-TMI (3Gy)|RADIATION: IM-TMI (6Gy)|RADIATION: IM-TMI (9Gy)|RADIATION: IM-TMI (12Gy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of an Interdisciplinary Fitness and Social Engagement Intervention
Status: TERMINATED
Conditions: TBI (Traumatic Brain Injury)
Interventions: BEHAVIORAL: InFuSE|BEHAVIORAL: Patient Education/Group Discussion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapy for High-Risk HPV 16-Positive Oropharynx Cancer Patients
Status: WITHDRAWN
Conditions: HPV Positive Oropharyngeal Squamous Cell Carcinoma|Oropharynx Cancer|HPV-Related Carcinoma
Interventions: DRUG: MEDI0457|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DETECT IV - A Study in Patients With HER2-negative Metastatic Breast Cancer and Persisting HER2-negative Circulating Tumor Cells (CTCs).
Status: COMPLETED
Conditions: HER2-negative and Hormone-receptor Positive Metastatic Breast Cancer|HER2-negative Circulating Tumor Cells|Postmenopausal Female Patients
Interventions: DRUG: Ribociclib|DRUG: Eribulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Trial to Investigate Efficacy and Safety of Vilobelimab in Ulcerative Pyoderma Gangrenosum
Status: RECRUITING
Conditions: Pyoderma Gangrenosum
Interventions: DRUG: vilobelimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT