pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: REVErsing Airway Remodelling With Tezepelumab
Status: RECRUITING
Conditions: Airway Remodelling, Asthmatic
Interventions: DRUG: Tezepelumab|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans
Status: RECRUITING
Conditions: Post Traumatic Stress Disorder (PTSD)|Depression|Anxiety
Interventions: BEHAVIORAL: Primary Care Brief Mindfulness Training (PCBMT)|BEHAVIORAL: Moving Forward (MF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Saftey and Efficacy of Pegfilgrastim in Preventing Chrmotherapy-induced Neutropenia
Status: UNKNOWN
Conditions: Neutropenia
Interventions: DRUG: pegfilgrastim,30mcg/kg|DRUG: pegfilgrastim, 60mcg/kg|DRUG: pegfilgrastim, 100mcg/kg|DRUG: filgrastim, 5mcg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exparel vs. Bupivacaine Hydrochloride vs. Placebo for Hernia Repair
Status: COMPLETED
Conditions: Analgesia, Postoperative
Interventions: DRUG: Exparel|DRUG: Bupivacaine Hcl 0.25% Inj|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fast-release Orodispersible Tramadol as Analgesia in Termination of Pregnancy by Vacuum Aspiration.
Status: UNKNOWN
Conditions: Fertility
Interventions: DRUG: fast release oro dispersible tramadol 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Controlling Femoral Derotation Osteotomy In Cerebral Palsy With Electromagnetic Tracking
Status: UNKNOWN
Conditions: Gait Disorders, Neurologic|Cerebral Palsy|Malalignment
Interventions: PROCEDURE: Femoral Derotation Osteotomy (FDO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Yizhi Baduanjin for Patients With Cognitive Impairment
Status: RECRUITING
Conditions: Mild Cognitive Impairment (MCI)
Interventions: OTHER: Yizhi Baduanjin (Eight Pieces of Brocades for Mental Health Promotion)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Demonstrate the Preliminary Safety and Effectiveness of IPBS in Performing MRI-Guided Targeting and Intervention of Breast Tissue in Female Patients Indicated for MRI-Guided Breast Biopsy
Status: COMPLETED
Conditions: Breast Cancer Screening|MRI Guided Breast Biopsy|Breast Cancer Diagnosis
Interventions: DEVICE: IPBS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: HEALEY ALS Platform Trial - Regimen G DNL343
Status: ENROLLING_BY_INVITATION
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: DNL343|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of Neuromuscular Training and Mobilization With Movement in Professional Athletes With Ankle Sprain
Status: COMPLETED
Conditions: Ankle Injuries|Musculoskeletal Manipulations
Interventions: OTHER: Closed Chain exercises|OTHER: Neuromuscular Training|OTHER: Mobilization with Movement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Glucose Control and Weight Loss Between Beinaglutide and Dulaglutide in Type 2 Diabetes With Overweight or Obesity.
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Overweight or Obesity
Interventions: DRUG: Beinaglutide|DRUG: Dulaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Adding Yoga Respiratory Training to Osteopathic Manipulative Treatment in Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: OTHER: Osteopathic manipulative treatment|OTHER: Yoga respiratory training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: One Month Performance Comparison Between Two Commercially Available Silicone Hydrogel Lenses
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Lotrafilcon B contact lens (AIR OPTIX® AQUA)|DEVICE: Galyfilcon A contact lens (ACUVUE® ADVANCE® Plus)|DEVICE: Contact lens solution (Clear Care®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cetuximab and Combination Chemotherapy in Treating Patients With Advanced or Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: fluorouracil|DRUG: irinotecan hydrochloride|DRUG: leucovorin calcium|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Delirium Severity by CAM-ICU 7 and 4C Mortality Score of the COVID-19 Patients in ICU
Status: UNKNOWN
Conditions: Delirium|Covid19|Intensive Care Unit Delirium
Interventions: OTHER: CAM-ICU 7 score|OTHER: 4C Mortality Score
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Healthy Online Parental Education Project to Increase Fruit and Vegetable Intake and Active Playtime Among Toddlers
Status: COMPLETED
Conditions: Eating Behavior
Interventions: BEHAVIORAL: Multi-Component eHealth Intervention, namely Healthy Online Parental Education (HOPE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evolutive Potential of Embryos Obtained From Oocytes After Luteal Phase Ovarian Stimulation
Status: COMPLETED
Conditions: INFERTILITY|Fertility Preservation|Ovulation Induction|Vitrification|Oocyte Donation
Interventions: DRUG: gonadotropins plus GnRH antagonists|DRUG: ganirelix
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Trastuzumab, Pertuzumab Plus Docetaxel in the Treatment of Early HER2-positive Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Pertuzumab|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet-rich Plasma for Meniscus Repair
Status: COMPLETED
Conditions: Platelet-Rich Plasma|Knee Injuries|Meniscus Disorder
Interventions: OTHER: platelet-rich plasma|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Midlevel Versus Physician-provided Medical Abortion in the Second Trimester
Status: COMPLETED
Conditions: Induced Abortion|Second Trimester Abortion|Medical Abortion|Health Personnel
Interventions: PROCEDURE: Provider type: Physicians|PROCEDURE: Provider type: Midlevel Providers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fractionated Radiation Therapy in Treating Advanced Squamous Cell Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: PROCEDURE: conventional surgery|RADIATION: low-LET cobalt-60 gamma ray therapy|RADIATION: low-LET electron therapy|RADIATION: low-LET photon therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Pyrotinib Combined With Capecitabine for Metastatic HER-2 Positive Colorectal Cancer
Status: UNKNOWN
Conditions: HER-2 Positive Colorectal Cancer
Interventions: DRUG: Pyrotinib in combination with capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Postoperative Effect of Expanded Pedicled Deltopectoral Flap to Repair the Facial-Cervical Scars
Status: UNKNOWN
Conditions: Surgical Flaps|Skin Pigmentation|Sensory Defect
Interventions: PROCEDURE: Expanded Pedicled Deltopectoral Flap
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Low-Intensity Blood Flow Restriction Training in Normoxia and Hypoxia Conditions
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypoxia, Altitude|Blood Flow Restriction|Resistance Training
Interventions: OTHER: low-intensity resistance training|OTHER: high-intensity resistance training|OTHER: low-intensity resistance training combined with blood flow restriction|OTHER: low-intensity resistance training in hypoxia condition|OTHER: low-intensity resistance training combined with blood flow restriction in hypoxia condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety of Febuxostat in Subjects With Gout.
Status: COMPLETED
Conditions: Gout
Interventions: DRUG: Febuxostat|DRUG: Febuxostat|DRUG: Febuxostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aminoglycoside Administration in Septic Patients
Status: RECRUITING
Conditions: Sepsis|Septic Shock|Aminoglycoside Toxicity|Renal Replacement Therapy
Interventions: PROCEDURE: Continuous Renal Replacement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: D-dimer to Predict Recurrence in Patients With Multiple Episodes of Venous Thromboembolism
Status: TERMINATED
Conditions: Venous Thromboembolism
Interventions: DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TQL-block for Laparoscopic Hemicolectomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Ropivacaine|DRUG: Acetaminophen|DEVICE: Patient controlled analgesia|DRUG: Morphine|DRUG: Saline|DIAGNOSTIC_TEST: Blood samples|BEHAVIORAL: Quality of recovery-15 questionaire|DIAGNOSTIC_TEST: Orthostatic hypotension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of a New Pediatric Formulation of Zidovudine/Lamivudine in Adult Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: administration of two anti-viral drugs (lamivudine and zidovudine) from a new oral formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate Two Guidelines for the Administration of Ibuprofen in the Treatment of Persistent Ductus Arteriosus Eco-guided: Impact in the Intestinal Prognosis
Status: UNKNOWN
Conditions: Persistent Ductus Arteriosus
Interventions: DRUG: Ibuprofen in continuous (24 hours) iv infusion and EchoG|DRUG: IV bolus Ibuprofen slow (15 minutes) and EchoG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Different Assisted Mechanical Ventilation in Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS) Patients
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Adult
Interventions: OTHER: Mechanical Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A First in Human Study to Assess Safety, Tolerability, Pharmacokinetics of ABI-4334 in Healthy Subjects
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: ABI-4334 Tablet|DRUG: ABI-4334 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Functionality of Male Condoms With a Silicone Elastomer Vaginal RIng
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: COMBINATION_PRODUCT: Placebo Vaginal Ring|DEVICE: Condom
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacokinetic Profile of Rosemary Extract Supplement
Status: NOT_YET_RECRUITING
Conditions: Pharmacokinetics
Interventions: DIETARY_SUPPLEMENT: Rosemary extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Platelet-Rich Fibrin Prepared With Titanium in the Treatment of Multiple Gingival Recessions
Status: COMPLETED
Conditions: Gingival Recession
Interventions: PROCEDURE: COMPARISON OF PLATELET-RICH FIBRIN PREPARED WITH TITANIUM AND SUBEPITHELIAL CONNECTIVE TISSUE GRAFT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Multicentre Study of Olaparib Maintenance Monotherapy in Platinum Sensitive Relapsed Non gBRCAm Ovarian Cancer Patients
Status: COMPLETED
Conditions: Non-Germline BRCA Mutated Ovarian Cancer
Interventions: DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Sodium-Restriction (DIS) and Renal Meals (RM) for Hemodialysis (HD)(DISaRM-HD)
Status: UNKNOWN
Conditions: Kidney Failure, Chronic|Dietary Modification
Interventions: DIETARY_SUPPLEMENT: Controlled Dietary Sodium Restriction|DIETARY_SUPPLEMENT: Control Diet & Controlled Dietary Sodium Restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nasal Irrigation Apply in Patients After Transsphenoidal Pituitary Tumor Resection
Status: UNKNOWN
Conditions: Pituitary Tumor
Interventions: BEHAVIORAL: nasal irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: To Assess the Safety and Efficacy of Ciclesonide, Applied as a Nasal Spray in the Treatment of Seasonal Allergic Rhinitis (BY9010/M1-401)
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal|Hay Fever
Interventions: DRUG: Ciclesonide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Infusion of Prostacyclin (Iloprost) vs Placebo for 72-hours in COVID-19 Patients With Respiratory Failure
Status: COMPLETED
Conditions: COVID-19|Respiratory Failure
Interventions: DRUG: Iloprost|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease
Status: RECRUITING
Conditions: Sickle Cell Disease
Interventions: GENETIC: nula-cel Drug Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tocilizumab and Cytokine Release Syndrome (CRS) In Covid-19 Pneumonia
Status: COMPLETED
Conditions: Cytokine Release Syndrome|Covid-19 Pneumonia
Interventions: DRUG: Tocilizumab 200 Mg/10 mL (20 Mg/mL) INTRAVEN VIAL (ML)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Osteoarthritis-related Pain
Status: TERMINATED
Conditions: Osteoarthritis|Osteoarthritis, Hip|Osteoarthritis, Knee|Pain|Arthralgia|Joint Pain
Interventions: DRUG: JNJ-42160443|DRUG: JNJ-42160443|DRUG: JNJ-42160443|DRUG: Placebo|DRUG: JNJ-42160443|DRUG: JNJ-42160443
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Tinzaparin on Cardio-vascular Outcomes and on Blood Lipids in Diabetic Patients on Chronic Hemodialysis
Status: WITHDRAWN
Conditions: Diabetes Mellitus|Hemodialysis
Interventions: DRUG: Tinzaparin administration|DRUG: Heparin administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Small/Middle Tier Cities and County Lung Cancer Quality Improvement Project (QIP) Study
Status: NOT_YET_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung|Lung Neoplasms|Respiratory Tract Neoplasms|Thoracic Neoplasms|Neoplasms by Site|Neoplasms|Lung Diseases|Respiratory Tract Diseases|Carcinoma, Bronchogenic|Bronchial Neoplasms
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PLX038 for Treatment of Metastatic Platinum-resistant Ovarian, Primary Peritoneal, and Fallopian Tube Cancer
Status: RECRUITING
Conditions: Platinum-Resistant Fallopian Tube Carcinoma|Platinum-Resistant Ovarian Carcinoma|Platinum-Resistant Primary Peritoneal Carcinoma|Stage IV Fallopian Tube Cancer AJCC v8|Stage IV Ovarian Cancer AJCC v8|Stage IV Primary Peritoneal Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|DRUG: Pegylated SN-38 Conjugate PLX038|PROCEDURE: Computed Tomography|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Single-Ascending-Dose, Safety, Tolerability, Pharmacokinetic(PK), and Pharmacodynamic(PD) Study of BIIB068 in Healthy Participants
Status: COMPLETED
Conditions: Systemic Lupos Erythematosus, SLE
Interventions: DRUG: BIIB068|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gene Expression Of Suppressor Of Cytokines in In Cutaneous Warts
Status: COMPLETED
Conditions: Warts
Interventions: DIAGNOSTIC_TEST: Detection of expression of SOCS3 gene|DIAGNOSTIC_TEST: Detection of expression of IFN-α gene|DIAGNOSTIC_TEST: Detection of expression of IFN-β gene
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Quetiapine Fumarate as Monotherapy in the Maintenance Treatment of Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Quetiapine Fumarate Sustained Release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injections for Post-Operative Pain Following Laparoscopic Colorectomy
Status: COMPLETED
Conditions: Post-Operative Pain
Interventions: DRUG: VVZ-149 Injections|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Smartphone App Enhanced Facilitation Among Veterans in a Mental Health Inpatient Setting (Project HOPE)
Status: NOT_YET_RECRUITING
Conditions: Suicide Prevention|Suicide Attempt|Suicidal Ideation
Interventions: BEHAVIORAL: Virtual Hope Box Enhanced Facilitation|BEHAVIORAL: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Investigate Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-55375515 in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-55375515 Dose Level 1|DRUG: JNJ-55375515 Dose Level 2|DRUG: JNJ-55375515 Dose Level 3|DRUG: JNJ-55375515 Dose Level 4|DRUG: JNJ-55375515 Dose Level 5|DRUG: JNJ-55375515 Dose Level 6|DRUG: Placebo|DRUG: JNJ-55375515
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Demonstrate Pharmacokinetic and Pharmacodynamic Biosimilarity Between HEC-Glargine and US-Lantus® in Healthy Male Volunteers
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus
Interventions: DRUG: HEC-Glargine|DRUG: US-Lantus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Different Medical Marijuana Strains on Motor and Cognitive Function in People With Multiple Sclerosis
Status: WITHDRAWN
Conditions: Multiple Sclerosis
Interventions: DRUG: Medical Marijuana|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: IMG-7289 in Patients With Essential Thrombocythemia (ET) or Polycythemia Vera (PV)
Status: ACTIVE_NOT_RECRUITING
Conditions: Essential Thrombocythemia|Polycythemia Vera
Interventions: DRUG: IMG-7289
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study Between Preservative With Benzalkonium Chloride vs Preservative Free Eye Drops on the Ocular Surface
Status: ACTIVE_NOT_RECRUITING
Conditions: Ocular Surface Disease|Dry Eye Syndromes
Interventions: DRUG: Dexamethasone, tobramycin, netilimicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Dose-finding Study to Evaluate the Change in Weight After Treatment With LIK066 in Japanese Patients With Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: LIK066|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Hydrochloride and Eribulin Mesylate in Treating Patients With Bladder Cancer That is Advanced or Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Metastatic Ureter Carcinoma|Metastatic Urethral Carcinoma|Stage III Bladder Urothelial Carcinoma AJCC v6 and v7|Stage III Ureter Cancer AJCC v7|Stage III Urethral Cancer AJCC v7|Stage IV Bladder Urothelial Carcinoma AJCC v7|Stage IV Ureter Cancer AJCC v7|Stage IV Urethral Cancer AJCC v7|Ureter Urothelial Carcinoma|Urethral Urothelial Carcinoma
Interventions: DRUG: Eribulin Mesylate|DRUG: Gemcitabine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ESPBs vs TAPs for Satisfactory Analgesia Following DIEP Surgery
Status: NOT_YET_RECRUITING
Conditions: Pain
Interventions: PROCEDURE: Pre-operative Erector Spinae Plane block prior to DIEP surgery|PROCEDURE: Pre-operative Transversus Abdominus Plane blocks prior to DIEP surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Short Term Weight Loss With Liraglutide and Metformin in Infertile Obese PCOS Patients
Status: COMPLETED
Conditions: Obesity|PCOS
Interventions: DRUG: Metformin|DRUG: Liraglutide + metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CHG Combined With Venetoclax and Azacytidine in Newly Diagnosed AML
Status: NOT_YET_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: CHG Combined With Venetoclax and Azacytidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Drug Study of Bexarotene and Rosiglitazone to Treat CTCL
Status: COMPLETED
Conditions: Cutaneous T-cell Lymphoma|Mycosis Fungoides|Sezary Syndrome
Interventions: DRUG: Rosiglitazone and Bexarotene
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors
Status: UNKNOWN
Conditions: Lymphoblastic Lymphoma
Interventions: DRUG: Anti-human Thymoglobulin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of RVL-1201 in Acquired Blepharoptosis
Status: COMPLETED
Conditions: Blepharoptosis
Interventions: DRUG: RVL-1201|DRUG: RVL-1201 Vehicle Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Strategies for Implementing GlobalConsent to Prevent Sexual Violence in University Men
Status: RECRUITING
Conditions: Violence, Sexual
Interventions: BEHAVIORAL: High-intensity implementation strategies (HIS)-Students|BEHAVIORAL: Low-intensity implementation strategies (LIS) for Students|OTHER: High-intensity implementation strategies (HIS) for Faculty|OTHER: Low-intensity implementation strategies (LIS) for Faculty|OTHER: High-intensity implementation strategies (HIS) for Leaders|OTHER: Low-intensity implementation strategies (LIS) for Leaders|OTHER: High-intensity implementation strategies (HIS) for Implementation Team Members|OTHER: Low-intensity implementation strategies (LIS) Implementation Team Members
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Sorbact® Antimicrobial Dressing in the Holistic Wound Management Of Diabetic Foot ulCers (Phase III Study)
Status: COMPLETED
Conditions: Foot Ulcer, Diabetic
Interventions: DEVICE: Sorbact®|DEVICE: Best local cares
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HDR Brachytherapy vs. LDR Brachytherapy Monotherapy in Localized Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: RADIATION: Permanent Iodine-125 seed implant|RADIATION: High-Dose-rate Prostate Brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Sonidegib and Buparlisib in Treating Patients With Advanced or Metastatic Basal Cell Carcinoma
Status: TERMINATED
Conditions: Carcinoma, Basal Cell|Recurrent Skin Cancer|Skin Neoplasms|Basal Cell Nevus Syndrome
Interventions: DRUG: Buparlisib|DRUG: Sonidegib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Fluocinolone Acetonide Intravitreal Implant in Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: fluocinolone acetonide|PROCEDURE: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: OASIS Wound Matrix (Oasis) Mechanism of Action
Status: COMPLETED
Conditions: Diabetic Foot Ulcers (DFU)|Venous Stasis Ulcers (VSU)
Interventions: DEVICE: OASIS Wound Matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Overcoming Barriers to Accessing Genetic Medicine
Status: ACTIVE_NOT_RECRUITING
Conditions: Genetic Disease|Genetic Predisposition
Interventions: OTHER: Access to Genetic Counselor for answering questions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Assessing the Feasibility, Acceptability and Effects Of HIV Birth Testing In Maternity Settings In Zimbabwe
Status: COMPLETED
Conditions: HIV/AIDS|Infant Morbidity|Perinatal HIV Infection|HIV Infections
Interventions: DIAGNOSTIC_TEST: Point of care early infant diagnosis (POC EID)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Performance of PureVision, Acuvue Oasys and O2Optix
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: PureVision Contact Lens|DEVICE: Acuvue Oasys Contact Lens|DEVICE: O2Optix Contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sensor and Electronic Health Records (EHR) Integration Pilot Study
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DEVICE: Mobile spirometer|DEVICE: Device sensor|DRUG: Salbutamol|DEVICE: Activity monitor|OTHER: electronic diary card|OTHER: CAT|OTHER: ACT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With a Complicated Regimen
Status: RECRUITING
Conditions: HIV-1-infection
Interventions: DRUG: Bictegravir|DRUG: Lenacapavir|DRUG: BIC/LEN FDC|DRUG: Stable Baseline Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Transpulmonary Pressure Guided Ventilation on Intraoperative Right Heart Function
Status: NOT_YET_RECRUITING
Conditions: Obesity|Surgery|Anesthesia|Echocardiography, Transesophageal|Mechanical Ventilation
Interventions: OTHER: Individualized lung-protective ventilation|OTHER: Standard lung-protective ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Low Carbohydrate Enteral Nutrition in Patients With Bacterial Septic Shock
Status: WITHDRAWN
Conditions: Bacterial Sepsis
Interventions: DIETARY_SUPPLEMENT: low-carbohydrate nutrition|DIETARY_SUPPLEMENT: Standard enteral nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PK/PD Investigation of Calciumfolinat in Blood, Tumor and Adjacent Mucosa in Patient With Colon Cancer
Status: UNKNOWN
Conditions: Colon Cancer|Chemotherapy
Interventions: DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of an add-on Treatment With Ivy Leaves Dry Extract on Lung Function in Bronchial Asthma
Status: UNKNOWN
Conditions: Asthma
Interventions: DRUG: ivy leaves dry extract|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Smoking Intervention Study Using Scheduled Gradual Reduction With Varenicline to Help With Cessation
Status: TERMINATED
Conditions: Nicotine Addiction
Interventions: OTHER: Scheduled Gradual Reduction + Varenicline|OTHER: Scheduled Gradual Reduction + Placebo Drug|OTHER: Basic Advice + Varenicline|OTHER: Basic Advice + Placebo Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Dasatinib as First-line Treatment for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia (CML-CP)
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia - Chronic Phase
Interventions: DRUG: Dasatinib Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest in the Use of Nasal High-Flow Oxygen Therapy (OptiFlow™) in Secondary Transport of COVID-19 Positive Patients
Status: COMPLETED
Conditions: COVID-19
Interventions: DEVICE: Use of high flow nasal oxygen therapy|DEVICE: Use of other non-invasive ventilation or high concentration oxygen masks
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigation of the Relationship Between Pain Sensitization and Diagnostic Parameters in Carpal Tunnel Syndrome
Status: RECRUITING
Conditions: Central Sensitisation|Carpal Tunnel Syndrome
Interventions: DIAGNOSTIC_TEST: Nerve ultrasound|DIAGNOSTIC_TEST: Nerve conduction studies|DIAGNOSTIC_TEST: Pressure pain threshold
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose Escalation Trial of CM310 in Patients With Moderate-to-Severe Atopic Dermatitis (AD)
Status: COMPLETED
Conditions: Moderate-to-severe Atopic Dermatitis
Interventions: DRUG: CM310|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Darapladib on Cantharidin-Induced Inflammatory Blisters in Subjects With Type 2 Diabetes Mellitus (T2DM)
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DRUG: Darapladib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Investigation and Modulation of the Mu-Opioid Mechanisms in Migraine (in Vivo)
Status: TERMINATED
Conditions: Migraine
Interventions: DEVICE: Active Comparator|DEVICE: Sham Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Extension Study of Telbivudine, Lamivudine or Telbivudine Plus Lamivudine in Patients With Chronic Hepatitis B
Status: COMPLETED
Conditions: Hepatitis B
Interventions: DRUG: telbivudine|DRUG: lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Serum Insulin Response After Acute and Chronic Sucralose Ingestion in Healthy Volunteers With Variable Body Mass Index
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: sucralose 48 mg (splenda)/day for ten weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: Improving the Approach to and Management of the Older Metastatic Breast Cancer Patient
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: BEHAVIORAL: Didactic session|BEHAVIORAL: Comprehensive Geriatric Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: International Collaborative Treatment Protocol For Children And Adolescents With Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: PEG-L-asparaginase|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: prednisone|DRUG: thioguanine|DRUG: vincristine sulfate|DRUG: vindesine|DRUG: daunoxome|DRUG: fludarabine|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Technology Assisted Treatment for Binge Eating Behavior
Status: NOT_YET_RECRUITING
Conditions: Binge-Eating Disorder
Interventions: BEHAVIORAL: Smartwatch app to deliver binge-eating CBT strategies|BEHAVIORAL: Reminder control condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Investigation of the Effects of Technology Supported Different Physiotherapy Approaches on Patients With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: OTHER: Technology Supported Task-Oriented Circuit Training|OTHER: Home-based Telerehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of TENS in Autonomous System in Women With Overactive Bladder
Status: UNKNOWN
Conditions: Urinary Bladder, Overactive
Interventions: OTHER: Intervention group|OTHER: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate if Early Atrial Fibrillation (AF) Diagnosis Reduces Risk of Events Like Stroke in the Real-World
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: Heart healthy Engagement Program with the Apple Watch Series 5 or later|DEVICE: Anti-Coagulation Adherence Module with the Apple Watch Series 5 or later
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Role of Acupuncture for the Treatment of Obstructive Sleep Apnea in Patients With Hypertension
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: OTHER: acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: European iNvestigation of SUrveillance After Resection for Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer|Metastatic Cancer|Recurrent Esophageal Cancer|Chemoradiation|Chemotherapy|Radiation|Surgery
Interventions: OTHER: High intensity postoperative oncologic surveillance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Evaluating the Efficacy of a Double Immunotherapy Combined With Olaparib in Patients With Solid Cancers and Carriers of Homologous Recombination Repair Genes After Olaparib Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Immunotherapy
Interventions: DRUG: olaparib, durvalumab, tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)
Status: RECRUITING
Conditions: Severe Sepsis or Septic Shock
Interventions: DRUG: Comparison 1: Prehospital Ceftriaxone|DRUG: Comparison 1: Placebo|DRUG: Comparison 2: Liberal fluids|DRUG: Comparison 2: Conservative fluids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fludarabine, Rituximab, and Lenalidomide in Minimally Treated/Untreated Patients With Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: lenalidomide|DRUG: Rituximab|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ANDDI-PRENATOME - Feasibility Study for a " Fast " Pangenomic High Throughput Sequencing Analysis in Prenatal Diagnosis
Status: UNKNOWN
Conditions: Prenatal|Genome-wide High Throughput Sequencing
Interventions: BIOLOGICAL: Invasive fetal sampling, blood sampling of mother and father|BIOLOGICAL: blood sampling from the mother to recover the circulating cell free fetal DNA|OTHER: Parent interviews (optional organizational study)|OTHER: parent questionnaire (optional organizational study)|OTHER: professional interviews (optional organizational study)|OTHER: Focus group for professionals (optional organizational study)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fruquintinib Combined With mFOLFOX6/FOLFIRI in First-line Treatment for Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Fruquintinib Combined With mFOLFOX6/FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Efficacy of Acapatamab in Subjects With mCRPC
Status: COMPLETED
Conditions: Metastatic Castration-resistant Prostate Cancer|Prostate Cancer
Interventions: DRUG: acapatamab|DRUG: Pembrolizumab|DRUG: Etanercept|DRUG: Cytochrome P450 (CYP) Cocktail
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bendamustine, Gemcitabine and Vinorelbine (BeGEV) as Induction Therapy in Relapsed/Refractory Hodgkin's Lymphoma Patients
Status: UNKNOWN
Conditions: Hodgkin's Lymphoma
Interventions: DRUG: Bendamustine|DRUG: Gemcitabine|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Usefulness of a Telemedicine System for OSA Patients Follow-up With High Cardiovascular Risk
Status: TERMINATED
Conditions: Sleep Apnea, Obstructive|Obstructive Sleep Apnea Syndrome
Interventions: DEVICE: Telemedicine|DEVICE: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging
Status: COMPLETED
Conditions: Epilepsy|Cerebral Palsy|Developmental Delay
Interventions: DRUG: Dexmedetomidine bolus and high infusion-Propofol|DRUG: Dexmedetomidine bolus and low infusion-Propofol|DRUG: Dexmedetomidine bolus only - Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Assessment and Prevention of Pain During Ovarian Stimulation in Patients With Endometriosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometriosis|Ovarian Hyperstimulation
Interventions: DRUG: Placebo oral tablet|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Single-arm Trial to Evaluate the Biodistribution and Shedding of Talimogene Laherparepvec
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Talimogene laherparepvec
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Two Different Feedbacks in Core Stabilization Education for Chronic Nonspecific Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain, Mechanical, Biofeedback, Pain, Chronic
Interventions: OTHER: Biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mechanistic Prehabilitation
Status: WITHDRAWN
Conditions: Colon Cancer|Rectal Cancer
Interventions: OTHER: Prehabilitation|DEVICE: hyperinsulinemic euglycemic isoaminoacid clamp|DEVICE: hyperinsulinemic euglycemic hyperaminoacid clamp|DIETARY_SUPPLEMENT: whey protein supplementation|OTHER: Prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Acupuncture and the Therapist´s Communication on Chemotherapy Induced Nausea and Vomiting
Status: RECRUITING
Conditions: Breast Cancer|Colorectal Cancer|Bladder Cancer|Testicular Cancer|Chemotherapy-induced Nausea and Vomiting
Interventions: OTHER: Standard care|DEVICE: Sham acupuncture|DEVICE: Genuine acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Antihypertensive Effect of Hyzaar(R) and Cognitive Function of Hypertensive Patients (0954A-322)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: losartan potassium (+) hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Bulk-Fill Composite Resins in Class II Restorations
Status: ACTIVE_NOT_RECRUITING
Conditions: Class II Dental Caries
Interventions: DEVICE: VisCalor Bulk,VOCO,Germany|DEVICE: Admira Fusion x-tra,VOCO,Germany|DEVICE: Filtek One Bulk,3M,Germany
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: One-Year Trial of Oral Ziprasidone in Bipolar Patients With Metabolic Syndrome
Status: TERMINATED
Conditions: Bipolar Disorder
Interventions: DRUG: Ziprasidone HCL (oral)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Neck Stabilization Exercise With Heat Therapies
Status: COMPLETED
Conditions: Neck Pain
Interventions: OTHER: neck stabilization exercise (nse)|OTHER: NSE + HOT PACK THERAPY|OTHER: NSE + infrared therapy|OTHER: NSE + ultrasound therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Paravertebral Block and Subcostal Transversus Abdominis Plane Block in Laparoscopic Nephrectomy
Status: COMPLETED
Conditions: Analgesia|Anesthesia|Pain, Postoperative
Interventions: DRUG: Bupivacain|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT