pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase II Study to Evaluate the Efficacy and Safety of Fruquintinib Plus Sintilimab as Third-line Therapy for Colorectal Cancer
Status: UNKNOWN
Conditions: Metastasis Colorectal Cancer
Interventions: DRUG: fruquintinib|DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Utility of Caduet in Achieving Blood Pressure and Lipid Endpoints in a Specific Patient Population
Status: COMPLETED
Conditions: Hypertension|Dyslipidemia
Interventions: DRUG: Amlodipine/Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ozone Injection for Shoulder Impengement Syndrome
Status: COMPLETED
Conditions: Research on the Effectiveness of a Corticosteroid, Single Dose and Three Doses of Ozone Injection in Shoulder Impingement Syndrome
Interventions: COMBINATION_PRODUCT: combined oxygen-ozone and corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Exenatide on Cardiovascular Exercise Performance in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Exenatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Feasibility Study of Transcranial Ultrasound Stimulation (TUS) on Stroke Patients
Status: RECRUITING
Conditions: Intracerebral Hemorrhage|Hemiplegia
Interventions: DEVICE: Transcranial ultrasound stimulation and rehabilitation|DEVICE: Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GX-I7 in Combination With Bevacizumab in Recurrent Glioblastoma (GBM) Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Glioblastoma
Interventions: DRUG: GX-I7|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intrathecal Morphine in Children Undergoing Major Abdominal Surgeries,
Status: UNKNOWN
Conditions: Major Abdominal Surgeries
Interventions: DRUG: Intrathecal Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Glucose Fluctuation Intervention on the Prognosis of Patients With Type 2 Diabetes and Cerebral Infarction
Status: UNKNOWN
Conditions: Type 2 Diabetes and Cerebral Infarction
Interventions: BEHAVIORAL: Control group|BEHAVIORAL: Glucose fluctuation targeted intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quality of Life in Locally Advanced or Metastatic Pancreatic Cancer Treated With Gemcitabine and Nab-paclitaxel
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Nab-paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alleviation Of Metabolic Endotoxemia In Adults With Metabolic Syndrome With Milk Fat Globule Membrane
Status: COMPLETED
Conditions: Metabolic Syndrome|Metabolic Endotoxemia
Interventions: DIETARY_SUPPLEMENT: MFGM-enriched full-fat dairy milk|DIETARY_SUPPLEMENT: Soy phospholipid/lecithin milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Telehealth Interventions for Post-Trauma Stress
Status: COMPLETED
Conditions: Post Traumatic Stress Disorders
Interventions: BEHAVIORAL: Mindfulness Telehealth Intervention|BEHAVIORAL: Psychoeducation Telehealth Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Immunogenicity of V114 in Healthy Adults and Infants (V114-004)
Status: COMPLETED
Conditions: Streptococcus Pneumoniae Infection|Pneumococcal Infections
Interventions: BIOLOGICAL: Prevnar 13®|BIOLOGICAL: V114 1x:1x:1x|BIOLOGICAL: V114 2x:2x:2x|BIOLOGICAL: V114 2x:1x:2x|BIOLOGICAL: V114 1x:1x:2x|BIOLOGICAL: V114 0.5x:0.5x:2x
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Reiki on Anxiety, Stress and Comfort Levels
Status: COMPLETED
Conditions: Reiki|Gastro-Intestinal Disorder
Interventions: OTHER: Reiki|OTHER: Sham reiki
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Efficacy and Safety of Phosphatidylserine-Omega3 in Children With Attention-Deficit/ Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention Deficit/Hyperactivity Disorder (ADHD)
Interventions: DIETARY_SUPPLEMENT: Phosphatidylserine-Omega3|OTHER: Colored cellulose tainted with fishy odor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Halitosis With Photodynamic Therapy in Older Patients
Status: COMPLETED
Conditions: Halitosis
Interventions: RADIATION: Photodynamic therapy|DEVICE: Treatment with tongue scraper|PROCEDURE: Periodontal treatment|PROCEDURE: hygiene procedures for the mucosa and dentures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Decitabine in Patients With Acute Myelogenous Leukemia or Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Physical Activity to Reduce Pain and Fatigue in Adults With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: BEHAVIORAL: Lifestyle physical activity (LPA)|BEHAVIORAL: Fibromyalgia education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Low-level Laser Therapy in the Fatigue Muscle of Healthy Individual and Spastic Individuals
Status: UNKNOWN
Conditions: Fatigue|Stroke Sequelae
Interventions: OTHER: Low-level laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Abemaciclib in Treating Patients With Advanced, Refractory, and Unresectable Digestive System Neuroendocrine Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Digestive System Neuroendocrine Neoplasm|Digestive System Neuroendocrine Tumor|Foregut Neuroendocrine Tumor|Hindgut Neuroendocrine Tumor|Locally Advanced Unresectable Digestive System Neuroendocrine Neoplasm|Metastatic Digestive System Neuroendocrine Neoplasm|Midgut Neuroendocrine Tumor|Pancreatic Neuroendocrine Tumor|Refractory Digestive System Neuroendocrine Neoplasm
Interventions: DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Serious Game on Knowledge, Attitude and Practice in Vector Control and Dengue Prevention Among Adults in Primary Care
Status: COMPLETED
Conditions: Dengue
Interventions: OTHER: Serious game|OTHER: Dengue prevention website
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Robotic Versus Laparoscopic Surgery for Patients With Pancreatic Cystic Neoplasms
Status: RECRUITING
Conditions: Pancreatic Neoplasm
Interventions: PROCEDURE: Robotic pancreaticoduodenectomy|PROCEDURE: Laparoscopic pancreaticoduodenectomy|PROCEDURE: Robotic Distal Pancreatectomy|PROCEDURE: Laparoscopic Distal Pancreatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Radiotherapy (SBRT) for Pulmonary Metastases in Ewing Sarcoma, Rhabdomyosarcoma, and Wilms Tumors
Status: TERMINATED
Conditions: Ewing Sarcoma|Rhabdomyosarcoma|Wilms Tumor|Osteosarcoma|Non-Rhabdomyosarcoma Soft Tissue Sarcoma, Nos|Renal Tumor|Rhabdoid Tumor|Clear Cell Renal Cell Carcinoma|Sarcoma|Sarcoma, Ewing|Soft Tissue Sarcoma
Interventions: RADIATION: Stereotactic Body Radiotherapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of GDC-0853 in Patients With Resistant B-Cell Lymphoma or Chronic Lymphocytic Leukemia.
Status: COMPLETED
Conditions: Lymphocytic Leukemia, Chronic, Diffuse Large B-Cell Lymphoma
Interventions: DRUG: GDC-0853
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effect of Resistance Training for Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer|Surgery|Chemotherapy Effect|Radiotherapy Side Effect|Pain, Chronic
Interventions: OTHER: Training|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive-Behavioral Therapy for Disruptive Behavior in Children and Adolescents
Status: COMPLETED
Conditions: Disruptive Behavior|Aggression|Anger|Irritability|Noncompliance
Interventions: BEHAVIORAL: Cognitive-Behavioral Therapy for Anger and Aggression|BEHAVIORAL: Supportive Psychotherapy (SPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Effects of Terlipressin and High Dose Octreotide
Status: COMPLETED
Conditions: Gastric and Esophageal Varices
Interventions: DRUG: Terlipressin|DRUG: Octreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Impact of Reduced Oxygen Concentration on Embryonic Development
Status: COMPLETED
Conditions: Infertility
Interventions: OTHER: 2% oxygen concentration in the incubator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating The Safety, Pharmacokinetics, and Efficacy Of Crovalimab Versus Eculizumab In Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors
Status: ACTIVE_NOT_RECRUITING
Conditions: Paroxysmal Nocturnal Hemoglobinuria
Interventions: DRUG: Crovalimab|DRUG: Eculizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of a Self-help Intervention for Depression in Patients With a Chronic Disease
Status: COMPLETED
Conditions: Depression|Diabetes Mellitus Type 2|Coronary Heart Disease
Interventions: BEHAVIORAL: Living Life to the Full
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Routine Irrigation With Ropivacaine vs. Lidocaine vs. Saline of Surgical Bed in Sleeve Gastrectomy
Status: UNKNOWN
Conditions: Overweight and Obesity
Interventions: DRUG: control saline|DRUG: Lidocaine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nobio Antimicrobial Particles Effect in a Split Mouth Model
Status: UNKNOWN
Conditions: Cervical Caries
Interventions: DEVICE: Nobio particles incorporated within Novidia Dental Bonding|DEVICE: Filtek bond and flow composite
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Development of Self-regulation by Dialectial Behavioural Therapy in Adults With Autism
Status: ENROLLING_BY_INVITATION
Conditions: Autism Spectrum Disorder|Regulation, Self
Interventions: BEHAVIORAL: Integrative Dialectical Behavioural Therapy (DBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amyloid Prediction in Early Stage Alzheimer's Disease Through Speech Phenotyping - FUTURE Extension
Status: TERMINATED
Conditions: Alzheimer Disease|Preclinical Alzheimer's Disease|Prodromal Alzheimer's Disease|Alzheimer's Disease (Incl Subtypes)|Mild Cognitive Impairment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Effectiveness of Cyclosporin in the Management of COVID19 ARDS Patients in Alexandria University Hospital
Status: COMPLETED
Conditions: COVID-19 Acute Respiratory Distress Syndrome|Cytokine Release Syndrome|Pulmonary Fibrosis
Interventions: DRUG: cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of RC48-ADC Combined With Toripalimab For First-line Treatment of Urothelial Carcinoma
Status: RECRUITING
Conditions: Urothelial Carcinoma|HER2-expressing
Interventions: DRUG: RC48-ADC|DRUG: Toripalimab|DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Anti-aging Efficacy of a Novel Skin Health Product
Status: COMPLETED
Conditions: Skin Aging
Interventions: OTHER: Topical Placebo Cream|OTHER: Topical Cream with 0.5% Active|OTHER: Topical Cream with 1% Active
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Effect of a Probiotic Supplement Upon Gastrointestinal Function
Status: UNKNOWN
Conditions: Signs and Symptoms, Digestive|Dyspepsia
Interventions: DIETARY_SUPPLEMENT: Probiotic mix CBP-004019/C|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Luteal Phase Versus Follicular Phase Administration of Clomiphene Citrate in PCOS, A Randomized Controlled Trial
Status: UNKNOWN
Conditions: PCOS
Interventions: DRUG: Clomiphene Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Phase I Safety and Immunogenicity Trial of Live Recombinant Canarypox ALVAC-HIV vCP205 Delivered by Alternate Mucosal Routes in HIV-1 Uninfected Adult Volunteers
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: MN rgp120/HIV-1 and GNE8 rgp120/HIV-1|BIOLOGICAL: ALVAC-HIV MN120TMG (vCP205)|BIOLOGICAL: ALVAC-RG Rabies Glycoprotein (vCP65)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Metabolic Effects of Pioglitazone in Type II Diabetic Patients Previously Treated With Insulin
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Insulin Resistance
Interventions: DRUG: pioglitazone and glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Complete Infarct Related Artery Revascularization in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DEVICE: Primary PCI of culprit lesion in IRA with drug eluting stent (DES)|DEVICE: Primary PCI of culprit lesion in IRA with drug eluting stent (DES) and PCI of the other critical lesion in IRA with another DES
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Acetaminophen on Postoperative Delirium Elderly Patients After Non-cardiac Surgery
Status: UNKNOWN
Conditions: Acetaminophen|Delirium in Old Age
Interventions: DRUG: Acetaminophen|DRUG: Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Web-Based Follow-Up Using Cellular Phone in Type 1 Diabetic Patients Under Insulin Pump Therapy : The PumpNet Study
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: Telemonitoring of glucose values using GlucoNet device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral Cimetidine in the Protoporphyrias
Status: RECRUITING
Conditions: Erythropoietic Protoporphyria|X-linked Protoporphyria
Interventions: DRUG: Cimetidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Two Versus Three Daily Injections in Children and Adolescents With Newly Diagnosed Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Twice Daily versus Three Times Daily Insulin Injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess ASP0598 Otic Solution Following Topical Application in the Ear in Subjects With Chronic Tympanic Membrane Perforation (CTMP)
Status: TERMINATED
Conditions: Chronic Tympanic Membrane Perforation
Interventions: DRUG: ASP0598|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Detect Progression of Mass Effect From Unilateral Brain Lesions
Status: ENROLLING_BY_INVITATION
Conditions: Non-traumatic Hemispheric Brain Lesions
Interventions: DEVICE: Non-invasive bilateral monitoring of ICP waveform
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Discontinuation of TyrosIne Kinase Inhibitors (TKI) in Chronic Myeloid Leukemia (CML) and Impact on the Immune System
Status: RECRUITING
Conditions: Tyrosine Kinase Inhibitors|Chronic Myeloid Leukemia
Interventions: DRUG: treatment of TKI in CML
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Versus Ezetimibe Plus Lifestyle in Patients With Non-alcoholic Steatohepatitis
Status: UNKNOWN
Conditions: •Non-alcoholic Steatohepatitis (NASH)
Interventions: DRUG: Ezetimibe|BEHAVIORAL: Lifestyle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Everolimus in a Cyclosporine Microemulsion-free Regimen Compared to a Low-dose Cyclosporine Microemulsion Regimen, in de Novo Kidney Transplant Patients
Status: COMPLETED
Conditions: Organ Transplantation, Renal Transplantation
Interventions: DRUG: Everolimus (Certican)|DRUG: Cyclosporine (Neoral)|DRUG: Steroid|DRUG: Basiliximab (Simulect)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-Dose Opiate Therapy for Discomfort in Dementia (L-DOT)
Status: COMPLETED
Conditions: Alzheimer Disease|Dementia|Dementia, Vascular|Pain
Interventions: DRUG: hydrocodone/APAP w placebo PRN|DRUG: hydrocodone/APAP|DRUG: placebo with hydrocodone/APAP PRN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Imaging Using Ferumoxtran-10 in Finding Metastases to the Axillary Lymph Nodes in Patients With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: ferumoxtran-10|PROCEDURE: magnetic resonance imaging|PROCEDURE: sentinel lymph node biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Multi-site Bridging Study of Nalfurafine Hydrochloride Orally Disintegrating Tablet
Status: UNKNOWN
Conditions: Uremic Pruritus
Interventions: DRUG: Nalfurafine Hydrochloride|DRUG: Nalfurafine Hydrochloride+Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation and the Development of Ongoing Muscle Pain
Status: COMPLETED
Conditions: Pain Relief
Interventions: DEVICE: Repetitive trancranial magnetic stimulation (rTMS) group|DEVICE: Sham group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Pioglitazone on Cardiovascular Outcome on Higashi-Saitama Trial in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes|Hypertension|Dyslipidemia|Diabetic Nephropathy
Interventions: DRUG: pioglitazone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tissue Glue vs Metallic Tackers in Mesh Fixation During TAPP Repair.
Status: COMPLETED
Conditions: Hernia
Interventions: PROCEDURE: tissue Glue for mesh fixation|PROCEDURE: Metallic Tackers for mesh fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Approval Study of the TREO Abdominal Stent-Graft System
Status: RECRUITING
Conditions: Abdominal Aortic Aneurysm
Interventions: DEVICE: TREO Abdominal Stent-Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: JP-1366 20mg Versus Esomeprazole 40mg in Patients With Erosive Esophagitis
Status: COMPLETED
Conditions: Erosive Esophagitis
Interventions: DRUG: JP-1366 20mg|DRUG: Esomeprazole 40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RNF and Betaseron® Tolerability Study
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis (RRMS)
Interventions: DRUG: New Formulation of rebif - human interferon beta-1a|DRUG: Interferon beta -1b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed in Combination With Erlotinib as a Salvage Treatment in Patients With Metastatic Biliary Tract Cancer (BTC) Who Failed Gemcitabine Containing Chemotherapy: A Phase II Single Arm Prospective Study
Status: UNKNOWN
Conditions: Biliary Tract Cancer
Interventions: DRUG: Pemetrexed 500 MG|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tiotropium Bromide Inhalation Solution in Subjects With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Tiotropium bromide inhalation solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Human IL-15 (rhIL-15) and Obinutuzumab for Relapsed and Refractory Chronic Lymphocyte Leukemia
Status: TERMINATED
Conditions: Leukemia|Lymphocytic|Chronic|B-Cell
Interventions: DRUG: rhIL-15|DRUG: rhIL-15|BIOLOGICAL: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fractional / Pixel CO2 Laser Treatment of Vulvar Atrophy and Lichen Sclerosus
Status: COMPLETED
Conditions: Vaginal Atrophy|Lichen Sclerosus
Interventions: DEVICE: Fractional / Pixel CO2 Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cetuximab After Immunotherapy for the Treatment of Head and Neck Squamous Cell Cancer
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma|Recurrent Head and Neck Squamous Cell Carcinoma|Metastatic Head-and-neck Squamous-cell Carcinoma
Interventions: DRUG: Cetuximab|OTHER: Questionnaire administration|OTHER: Quality of life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of Ad5-vector Based Vaccine Against Coronavirus Variants in Adults (≥18 Years) Immunized With 2 Doses of mRNA Vaccines Plus One Dose of Booster AZD1222 Vaccine
Status: WITHDRAWN
Conditions: COVID-19
Interventions: BIOLOGICAL: Bivalent Recombinant COVID-19 Vaccine (Adenovirus Type 5 Vector)|BIOLOGICAL: Bivalent Recombinant COVID-19 Vaccine (Adenovirus Type 5 Vector) for Inhalation|BIOLOGICAL: mRNA-based COVID-19 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Moxibustion Plus Cupping in Convalescent Patients With COVID-19
Status: UNKNOWN
Conditions: COVID-19|Convalescence
Interventions: OTHER: Moxibustion plus Cupping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media
Status: UNKNOWN
Conditions: Fuch's Endothelial Dystrophy|Pseudophakic Bullous Keratopathy
Interventions: PROCEDURE: Corneal transplantation|PROCEDURE: Corneal transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Trial of AC (Adriamycin, Cyclophosphamide) Chemotherapy With G-CSF (Granulocyte Colony-Stimulating Factor) Followed by Infusional Taxol (Paclitaxel) as Adjuvant Treatment for High Risk Stage II and Stage III Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer|Breast Neoplasms
Interventions: DRUG: Adriamycin|DRUG: cyclophosphamide|DRUG: G-CSF|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: 3D Evaluation of Powerscope Appliance in Treatment of Skeletal Class 2 Malocclusion
Status: COMPLETED
Conditions: Class II Malocclusion, Division 1
Interventions: DEVICE: Powerscope group
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection Of Neoplastic Tissue in Barrett's Esophagus With In vivO Probe-based Confocal Endomicroscopy
Status: COMPLETED
Conditions: Barrett Syndrome|Barrett's Syndrome|Barrett's Esophagus|Barrett Esophagus|Adenocarcinoma
Interventions: DEVICE: Imaging procedures (NBI)|DEVICE: HDWLE|DEVICE: pCLE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Laparoscopic Versus Open Mesh Repair of Bilateral Primary Inguinal Hernia
Status: COMPLETED
Conditions: Bilateral Inguinal Hernia
Interventions: PROCEDURE: Laparoscopic Trans-Abdominal Pre-Peritoneal|PROCEDURE: Open pre-peritoneal repair|PROCEDURE: Bilateral Lichtenstein repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Sacral Colpopexy Versus Modified Total Pelvic Floor Reconstructive Surgery for Apical Prolapse Stage III-IV
Status: UNKNOWN
Conditions: Uterine Prolapse|Vault Prolapse
Interventions: PROCEDURE: LSC|PROCEDURE: modified PFRS|DEVICE: "Gynemesh"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study of Mirtazapine 15 mg Tablets Under Non-fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Mirtazapine 15 mg tablets, single dose|DRUG: REMERON® 15 mg tablets, single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Sorafenib Relapase Prophylaxis After HCT With PTBCy Regimen
Status: RECRUITING
Conditions: Acute Myeloid Leukemia, in Relapse|Myelodysplastic Syndromes|Chronic Myeloid Leukemia|Myeloproliferative Neoplasm
Interventions: DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HoloLens: an Objective Alternative to the Operator's Memory
Status: COMPLETED
Conditions: Virtual Reality|Anesthesia|Epidural
Interventions: DEVICE: HoloLens-guided epidural|OTHER: US-guided epidural
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Multidisciplinary Collaboration Care in Pulmonary Arterial Hypertension (PAH)
Status: COMPLETED
Conditions: Hypertension, Pulmonary
Interventions: BEHAVIORAL: Patient education|OTHER: Data collection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Randomized Phase II Trial on Safety and Neutralizing Activity of CL184 and Rabies Vaccine Versus Human Rabies Immune Globulin (HRIG) and Rabies Vaccine in Children and Adolescents
Status: COMPLETED
Conditions: Rabies
Interventions: BIOLOGICAL: CL184|BIOLOGICAL: HRIG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Allopurinol and Trimetazidine as a Preventive of Acute Kidney Injury in PCI Patients
Status: RECRUITING
Conditions: AKI - Acute Kidney Injury
Interventions: DRUG: Trimetazidine 35 mg|DRUG: Allopurinol 300 MG|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intranasal Injection of PRP Versus Saline for Treatment of Olfactory Dysfunction
Status: COMPLETED
Conditions: Olfactory Disorder|Olfaction Disorders|Olfactory Nerve Injuries|Olfactory Nerve Disorder|Olfactory Nerve Diseases|Covid19|Post-Viral Disorder
Interventions: PROCEDURE: Injection into olfactory cleft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Mesenchymal Human Stem Cells Infusion Therapy for Endothelial DySfunctiOn in Diabetic Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: 20 million Allogeneic Mesenchymal Human Stem Cells|DRUG: 100 million Allogeneic Mesenchymal Human Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Decellularized Human Amniotic Membrane Hydrogel and Inverted Internal Limiting Membrane Flap in Idiopathic Large Macular Holes
Status: NOT_YET_RECRUITING
Conditions: Macular Holes
Interventions: PROCEDURE: 25-gauge pars plana vitrectomy with inverted flap technique and SF6 tamponade|PROCEDURE: 25-gauge pars plana vitrectomy with complete internal limiting membrane peeling with amniotic membrane hydrogel filling and SF6 tamponade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Endotracheal Intubation Using a Bougie Through the Air-Q Intubating Laryngeal Airway
Status: COMPLETED
Conditions: Airway Complication of Anaesthesia
Interventions: DEVICE: Air-Q
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: HiRes Infrared Imaging for Wrist Injuries in Children v2
Status: COMPLETED
Conditions: Fractures, Bone
Interventions: DEVICE: Thermal Imaging|DIAGNOSTIC_TEST: X-RAY
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Genotype-guided Versus Standard for Warfarin Dosing
Status: COMPLETED
Conditions: Atrial Fibrillation|Valvular Heart Disease
Interventions: OTHER: Gene-directed dosage of warfarin|OTHER: standard dosage of warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Felzartamab in Late Antibody-Mediated Rejection
Status: COMPLETED
Conditions: Antibody-mediated Rejection
Interventions: DRUG: Felzartamab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aerobic Interval Training v/s Resistance Interval Training On Ejection Fraction In Stable Post MI Patients
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: OTHER: Aerobic Interval Training|OTHER: Aerobic + Resistive Interval Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Acute Effect of Myofascial Release and Kinesiology Taping
Status: COMPLETED
Conditions: Low Back Pain|Kinesio Taping|Myofascial Release Technique
Interventions: OTHER: Myofascial Release Technique and Kinesiology Taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Efficacy and Safety of a Medical Device for the Treatment of Toenail Onychomycosis
Status: COMPLETED
Conditions: Onychomycosis of Toenail
Interventions: DEVICE: Solver Pen|DRUG: Loceryl 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Age on Response to the 2009 H1N1 Virus Vaccine
Status: COMPLETED
Conditions: 2009 H1N1 Influenza Virus
Interventions: BIOLOGICAL: 2009 H1N1 Virus Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Two NN1250 Formulations Versus Insulin Glargine, All in Combination With Metformin in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin glargine|DRUG: insulin degludec|DRUG: insulin degludec|DRUG: insulin degludec|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-Arm Study of the Efficacy and Safety of Oral Rigosertib in Patients With Myelofibrosis (MF) and Anemia
Status: TERMINATED
Conditions: Leukemia|Myelofibrosis|Anemia|Splenomegaly
Interventions: DRUG: Rigosertib|BEHAVIORAL: Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Seamless Controlled Trial To Evaluate Safety And Immunogenicity of Chikungunya Vaccine in LatinAmerica and Asia
Status: ACTIVE_NOT_RECRUITING
Conditions: Chikungunya
Interventions: DRUG: BBV87 Chikungunya vaccine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: RESpiration deTection From Implanted Cardiac Devices in Subjects With Heart Failure (REST-HF)
Status: UNKNOWN
Conditions: Heart Failure
Interventions: DEVICE: Cardiac Pacing and Impedance Measurement system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Capnography-Assisted Learned Monitored (CALM) Breathing Therapy for COPD
Status: COMPLETED
Conditions: COPD
Interventions: BEHAVIORAL: CALM Breathing|BEHAVIORAL: Traditional outpatient PR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Results of Maxillary Deficiency Treatment by Fixed Tongue Appliance and Fixed Facemask in Growing Patients
Status: UNKNOWN
Conditions: Maxillary Deficiency
Interventions: DEVICE: Fixed Tongue Appliance|DEVICE: Fixed Face Mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Haemodynamic and Metabolism Response During Early Rehabilitation in Sedated Patients
Status: COMPLETED
Conditions: Critically Ill Patients Under Mechanical Ventilation|Sedated Patients
Interventions: OTHER: Passive legs mobilisation|OTHER: Passive cycloergometer|OTHER: Muscular electrical stimulation|OTHER: FES cycling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: HKT-500 in Adult Patients With Ankle Sprain
Status: COMPLETED
Conditions: Ankle Sprain
Interventions: DRUG: HKT-500 Ketoprofen Topical Patch|OTHER: Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Cognitive-Behavioral Therapy for Children With High-Functioning Autism Spectrum Disorder and Anxiety
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Autism|Asperger Syndrome|PDD-NOS
Interventions: BEHAVIORAL: Coping Cat cognitive-behavioral therapy for anxious youth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pediatric GVHD Low Risk Steroid Taper Trial
Status: RECRUITING
Conditions: Acute Graft vs Host Disease|Allogeneic Bone Marrow Transplantation|Adverse Effects
Interventions: DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Prednisone in Treating Patients With Recurrent and/or Metastatic Kidney Cancer
Status: COMPLETED
Conditions: Kidney Cancer
Interventions: DRUG: estramustine phosphate sodium|DRUG: prednisone|DRUG: vinorelbine tartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study Assessing the Safety of Oral ATH-399A in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: ATH-399A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dendritic Cell Vaccine for Patients With Brain Tumors
Status: COMPLETED
Conditions: Glioma|Anaplastic Astrocytoma|Anaplastic Astro-oligodendroglioma|Glioblastoma
Interventions: BIOLOGICAL: autologous tumor lysate-pulsed DC vaccination|BIOLOGICAL: Tumor lysate-pulsed DC vaccination+0.2% resiquimod|BIOLOGICAL: Tumor-lysate pulsed DC vaccination +adjuvant polyICLC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First in Human Study of IMGN151 in Recurrent Endometrial Cancer and Recurrent, High-grade Serous Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers
Status: RECRUITING
Conditions: Endometrial Cancer|High Grade Serous Adenocarcinoma of Ovary|Primary Peritoneal Carcinoma|Fallopian Tube Cancer
Interventions: DRUG: IMGN151
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Nalbuphine and Naloxone on Experimentally Induced Skin Sensitivity
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: nalbuphine plus naloxone|DRUG: nalbuphine plus saline|DRUG: naloxone plus saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluate Therapeutic Equivalence and Safety of Two Clindamycin Phosphate and Benzoyl Peroxide Gels in Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Clindamycin Phosphate / Benzoyl Peroxide Gel|DRUG: Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/2.5%|DRUG: Placebo (Vehicle Gel)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Texting Intervention to Sustain HIV Prevention in Women in High-drug-use Contexts
Status: COMPLETED
Conditions: HIV|Syphilis|Gonorrhea|Chlamydia
Interventions: BEHAVIORAL: Mujer Segura Siempre|BEHAVIORAL: General Health Message Texts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Rapid Urease Test for Helicobacter Pylori in Population Who Stop Proton Pump Inhibitor Less Than 2 Weeks Compared With Histology
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DIAGNOSTIC_TEST: rapid urease test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Oocyte Survival After Vitrification in an Open or Closed Device With Closed Storage.
Status: COMPLETED
Conditions: Survival|Embryo Quality
Interventions: DEVICE: CBSvit HS device|DEVICE: Cryotop SC device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adipose Tissue Derived Stromal Vascular Fraction (SVF) Application in Treatment of Long Bones Nonunion
Status: COMPLETED
Conditions: Nonunion of Fracture
Interventions: BIOLOGICAL: autologous adipose tissue derived stromal vascular fraction (SVF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Bronchial Provocation Study With Mannitol and Methacolinie in a Korean Population
Status: COMPLETED
Conditions: Asthma
Interventions: PROCEDURE: methacholine and mannitol bronchial challenge tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Continuous Lumbar Plexus Block With and Without Parasacral Block in Patients Undergoing Total Hip Replacement
Status: TERMINATED
Conditions: Osteoarthritis of Hip|Regional Anesthesia|Other Acute Postoperative Pain|Total Hip Arthroplasty|Peripheral Nerve Block|Lumbar Plexus Nerve Block|Parasacaral (Sciatic) Nerve Block
Interventions: PROCEDURE: Continuous Lumbar Plexus Block|PROCEDURE: Parasacral Nerve Block|DRUG: Ropivacine 0.2%|DRUG: Bupivacaine 0.0625%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of INCB099280 in Combination With Adagrasib in Adults With Advanced Solid Tumors Harboring a KRASG12C Mutation
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: INCB099280|DRUG: adagrasib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Effectiveness & Long Term Health Study in Wisconsin Smokers
Status: COMPLETED
Conditions: Smoking Cessation|Smoking|Nicotine Dependence
Interventions: DRUG: Varenicline|DRUG: Nicotine lozenge|DRUG: Nicotine Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Usefulness of Extracorporeal Removal of sFLT-1 in Women With Very Early Severe Preeclampsia
Status: TERMINATED
Conditions: Preeclampsia
Interventions: DEVICE: Apheresis for extracorporal removal of sFlt-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Physical Activity on the Brain in Parkinson's Disease (PD)
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: BEHAVIORAL: stationary bike exercise|BEHAVIORAL: aerobic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety Tolerability and Pharmacokinetic of BI 411034
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 411034|DRUG: Placebo|DRUG: BI 411034|DRUG: BI 411034|DRUG: BI 411034|DRUG: BI 411034|DRUG: BI 411034|DRUG: BI 411034|DRUG: BI 411034
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: SHP2 Inhibitor BBP-398 in Combination With Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer With a KRAS Mutation
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer|Solid Tumor
Interventions: DRUG: BBP-398 with nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT