pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Project BEST: Buprenorphine Entry Into Substance Abuse Treatment
Status: COMPLETED
Conditions: Opioid-related Disorders|HIV Infections|Hepatitis C, Chronic|Depression
Interventions: BEHAVIORAL: MET/CBT based individualized counseling|DRUG: Buprenorphine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The ARCT-154 Self-Amplifying RNA Vaccine Efficacy Study (ARCT-154-01)
Status: COMPLETED
Conditions: COVID-19 Vaccines
Interventions: BIOLOGICAL: ARCT-154 Self-Amplifying RNA SARS-CoV-2 Vaccine|OTHER: Placebo (normal saline)|BIOLOGICAL: Astra Zeneca COVID-19 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: GoalNav® Clinic Module - Pilot Trial
Status: NOT_YET_RECRUITING
Conditions: Geriatric Assessment
Interventions: BEHAVIORAL: Goal Attainment Scaling (GAS) with a goal inventory|BEHAVIORAL: Goal Attainment Scaling (GAS) without inventory
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Transesophageal Echocardiography(TEE) Probe Insertion and Tracheal Cuff Pressure
Status: COMPLETED
Conditions: Intubation, Intratracheal
Interventions: PROCEDURE: balloon pressure adjustment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Thoracolumbar Interfascial and Erector Spinae Plane Block on Analgesic Efficiency of After Spinal Surgery
Status: UNKNOWN
Conditions: Postoperative Pain|Postoperative Nausea and Vomiting|Opioid Use
Interventions: PROCEDURE: Bilateral 20 ml 0.25 % Bupivacaine with 2mg preservative free dexametasone and 5mcg/ml epinephrine injected between multifidus and longissimus muscle with USG guidance|PROCEDURE: Bilateral 20 ml 0.25 % Bupivacaine with 2mg preservative free dexametasone and 5mcg/ml epinephrine injected between the erector spinae muscles and transverse process with USG guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Lubiprostone on Small Bowel Contractions in Female Patients With Constipation Irritable Bowel Syndrome (C-IBS)
Status: COMPLETED
Conditions: Constipation-predominant Irritable Bowel Syndrome
Interventions: DRUG: Lubiprostone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Salmeterol and Fluticasone Propionate Absorption From Salmeterol/Fluticasone Easyhaler and Seretide Diskus
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Seretide Diskus and charcoal|DRUG: Seretide Diskus|DRUG: SF Easyhaler and charcoal|DRUG: SF Easyhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Somatosensory Modulation of Salivary Gene Expression and Oral Feeding in Preterm Infants
Status: COMPLETED
Conditions: Infant, Extremely Low Birth Weight|Feeding Behavior
Interventions: DEVICE: NTrainer|DEVICE: SHAM blind pacifier
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Intuitive, Non-intrusive, Approach to Reduce Patient Harm From Inappropriate Dosing of High-risk Drugs in Older Adult Patients Across an Urban Safety Net Hospital System
Status: COMPLETED
Conditions: Potentially Inappropriate Medications
Interventions: BEHAVIORAL: EHR-based "nudge" interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Tolerability of MK-5478 in Participants With Hypertension (5478-001)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: MK-5478|DRUG: Comparator: Candesartan cilexetil|DRUG: Comparator: Pbo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Encouraging Abstinence Behavior in a Drug Epidemic
Status: RECRUITING
Conditions: Opioid-use Disorder|Cocaine Use Disorder|Opioid Use|Cocaine Use|Substance Use|Methamphetamine Abuse|Methamphetamine-dependence
Interventions: DEVICE: App-Based Contingency Management|BEHAVIORAL: Sham Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Transcutaneous Vagus Nerve Stimulation in Chronic Pain Patients and Healthy Controls
Status: ACTIVE_NOT_RECRUITING
Conditions: Restless Legs Syndrome|Chronic Pain
Interventions: DEVICE: Transcutaneous vagus nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Efficacy Trial of Electroacupuncture at Points of Bilateral BL33 for Mild and Moderate Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia (BPH)
Interventions: DEVICE: needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Orelabrutinib, Rituximab and Combination Chemotherapy in Newly-diagnosed Aggressive B-cell Non-Hodgkin Lymphoma
Status: RECRUITING
Conditions: High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements|High Grade B-Cell Lymphoma, Not Otherwise Specified|Diffuse Large B-cell Lymphoma|Mantle Cell Lymphoma|B-cell NonHodgkin Lymphoma
Interventions: DRUG: Orelabrutinib+R-CHOP; Orelabrutinib+R-DA-EPOCH; Orelabrutinib+R-HD MTX;Orelabrutinib+R+other chemotherapies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Model Towards Elimination of Hepatitis C Infection in Egypt: Feasibility and Effectiveness in 73 Villages
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DIAGNOSTIC_TEST: HCV antibody and hepatitis B surface antigen (HBsAg) rapid diagnostic tests|DRUG: DAAs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: HIRREM for Pre-Hypertension
Status: WITHDRAWN
Conditions: Prehypertension|Blood Pressure|Autonomic Nervous System Imbalance|Cardiovascular Risk Factor|Cardiovascular Diseases|Brain Diseases
Interventions: DEVICE: HIRREM|OTHER: Ambient Nature Sounds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acne Treatment With Active Oplon's Patches
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DEVICE: Oplon Active Patch|DEVICE: Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Simulator Training and Its Impact on Surgical Education
Status: COMPLETED
Conditions: Surgical Procedure, Unspecified|Surgical Simulation
Interventions: PROCEDURE: Laparoscopic Simulation training|PROCEDURE: Traditional Surgical Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: To Investigate the Gastrointestinal Behaviour of Two Triple Combination Products in Healthy Male Volunteers
Status: COMPLETED
Conditions: Common Cold
Interventions: DRUG: Acetaminophen 650mg+Dextromethorphan 20mg+Phenylephrine 10mg|DRUG: Acetaminophen 325mg+Dextromethorphan 10mg+Phenylephrine 5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Handheld Ultrasound Device to Triage Women With a Positive Clinical Breast Examination by Trained Non-radiologists
Status: RECRUITING
Conditions: Breast Cancer|Carcinoma in Situ
Interventions: OTHER: Triage of clinical breast examination positive women using handheld ultrasound by non-radiologists.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effect of Home Exercise Program on Various Parameters in Patients With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Exercise Program|Telerehabilitation|Autoimmune Disorder
Interventions: OTHER: Fatigue Severity Scale|OTHER: Berg Balance Test|OTHER: Time up and go- 25 steps walking test|OTHER: Multiple Sclerosis Quality of Life|OTHER: Brief International Cognitive Assessment for MS (BICAMS)|OTHER: Beck Depression and Anxiety Scale
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Orally Administered IPG7236 in Healthy Adult Participants
Status: UNKNOWN
Conditions: Atopic Dermatitis
Interventions: DRUG: IPG7236- Single ascending dose|DRUG: IPG7236- Multiple ascending dose|OTHER: Placebo (Part A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Primary Prophylaxis of Cerebral Toxoplasmosis in HIV-Infected Patients
Status: COMPLETED
Conditions: Toxoplasmosis, Cerebral|HIV Infections
Interventions: DRUG: Pyrimethamine|DRUG: Leucovorin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: The Role of Immune Semaphorins in NAFLD
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease|Immune Response|Biomarkers|Liver Fibrosis|Non Alcoholic Steatohepatitis
Interventions: DIAGNOSTIC_TEST: Evaluation of the degree of fibrosis and steatosis|DIAGNOSTIC_TEST: Screening for the components of metabolic syndrome|DIAGNOSTIC_TEST: Measurement of serum semaphorin concentrations|DIAGNOSTIC_TEST: Identification of semaphorin gene polymorphisms
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparation of Proseal Laryngeal Mask Airway With Flexible Laryngeal Airway Mask
Status: UNKNOWN
Conditions: Anesthesia Intubation Complication
Interventions: DEVICE: flexible laryngeal airway mask|DEVICE: proseal laryngeal mask airway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Intralesional Cryotherapy With a Argon Gas Based Device for the Treatment of Keloid and Hypertrophic Scars
Status: COMPLETED
Conditions: Keloid|Cicatrix|Hypertrophic
Interventions: PROCEDURE: Intralesional cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-nutritive Sucking and Breastfeeding in Preterm Infants
Status: COMPLETED
Conditions: Infant,Premature|Infant Development|Infant, Very Low Birth Weight
Interventions: OTHER: Rehabilitative|OTHER: Active Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Quadrivalent Influenza Vaccine (GSK2282512A) Compared to Fluzone® Quadrivalent in Children 6 to 35 Months of Age
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: FluLaval™ Quadrivalent|BIOLOGICAL: Fluzone® Quadrivalent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Olaparib (Lynparza™) Versus Enzalutamide or Abiraterone Acetate in Men With Metastatic Castration-Resistant Prostate Cancer (PROfound Study)
Status: COMPLETED
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: olaparib|DRUG: enzalutamide|DRUG: abiraterone acetate|DRUG: abiraterone acetate|DRUG: enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of kınesıologıcal tapıng, mobılızatıon and breathıng exercıse on paın and Comfort After Caesarea
Status: NOT_YET_RECRUITING
Conditions: Nurse|Cesarean Section|Postpartum Comfort
Interventions: OTHER: BREATHING EXERCISE AND MOBILIZATION TRAINING|OTHER: KINESIOLOGICAL TAPING + BREATHING EXERCISE AND MOBILIZATION TRAINING
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Swine-Origin A/H1N1 Influenza Non-Adjuvanted Vaccine in Healthy Adults in India
Status: COMPLETED
Conditions: Influenza|Pandemic Influenza|Influenza A Virus, H1N1 Subtype
Interventions: BIOLOGICAL: A/H1N1 pandemic influenza vaccine (non- adjuvanted)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: BLI800-303: An Efficacy Evaluation of 2 Different Bowel Cleansing Preparations in Adult Subjects
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: BLI800|DRUG: Polyethylene glycol 3350 based bowel preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Semorinemab in Patients With Prodromal to Mild Alzheimer's Disease
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: Semorinemab|DRUG: Placebo|DRUG: [18F]GTP1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Open-Label, Safety Study Of Sitaxentan Sodium In Japanese Pulmonary Arterial Hypertension Patients
Status: TERMINATED
Conditions: Hypertension, Pulmonary
Interventions: DRUG: Sitaxentan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ocular Microvascular Changes in Patients With Sepsis
Status: COMPLETED
Conditions: Sepsis|Retinal Microcirculation Disorder|Conjunctiva; Disorder
Interventions: DEVICE: Incident dark field videomicroscope from Braedius|DEVICE: Fundus camera from Optomed
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 3 Study to Compare Upadacitinib to Abatacept in Subjects With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease- Modifying Antirheumatic Drugs (csDMARDs) Who Have an Inadequate Response or Intolerance to Biologic DMARDs
Status: COMPLETED
Conditions: Rheumatoid Arthritis (RA)
Interventions: DRUG: Abatacept|DRUG: Placebo for abatacept (0.9% Sodium Chloride Injection or Solution for Infusion)|DRUG: Upadacitinib|DRUG: Placebo for upadacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Zydena (Udenafil) on Cerebral Blood Flow and Peripheral Blood Viscosity
Status: UNKNOWN
Conditions: Vascular Dementia|Subcortical Vascular Dementia
Interventions: DRUG: Zydena (Udenafil)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Chronic Mitochondrial Antioxidant Supplementation on CardiovascularToxicity in Breast Cancer Patients
Status: UNKNOWN
Conditions: Breast Neoplasms
Interventions: DRUG: Mitoquinone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ONO-4538 in Unresectable Advanced or Recurrent Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: ONO-4538|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MoVE Trial: Motivational Strategies to Empower African Americans to Improve Dialysis Adherence
Status: RECRUITING
Conditions: End Stage Renal Disease on Dialysis
Interventions: BEHAVIORAL: Motivational interviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Trial to Assess the Effects of Vorapaxar (SCH 530348; MK-5348) in Preventing Heart Attack and Stroke in Particpants With Acute Coronary Syndrome (TRA•CER) (Study P04736)
Status: TERMINATED
Conditions: Atherosclerosis|Myocardial Ischemia|Myocardial Infarction
Interventions: DRUG: Vorapaxar|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy Study of Digibind for Treatment of Severe Preeclampsia
Status: COMPLETED
Conditions: Pre-eclampsia
Interventions: DRUG: Anti-digoxin antibody (FAB fragment)|OTHER: sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple Dose Safety Study of PF-04802540 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-04802540|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Outcomes of Tolerating Subretinal Fluid in Type 1 MNV and PCV
Status: COMPLETED
Conditions: Polypoidal Choroidal Vasculopathy|Choroidal Neovascularization|Age-Related Macular Degeneration
Interventions: DRUG: Intravitreal aflibercept injection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Broad Spectrum HPV Vaccine Tolerability, Immunogenicity, and Efficacy Study (V502-003)
Status: WITHDRAWN
Conditions: Cervical Cancer|Condylomata Acuminata
Interventions: BIOLOGICAL: V502
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Pulmonary Rehabilitation for Chronic Obstructive Pulmonary Disease (COPD) Exacerbation
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: early pulmonary lung rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ESPB vs PVB vs QLB After Pelvi-ureteric Surgeries
Status: COMPLETED
Conditions: Erector Spinae Plane Block|Paravertebral Block|Quadratus Lumborum Block|Analgesia
Interventions: PROCEDURE: ESPB Technique|PROCEDURE: TPVB Technique|PROCEDURE: QLB Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Enhanced Protein (Dairy) Weight Loss Intervention for Dynapenic Obesity: Impact on Muscle Quality and Composition
Status: COMPLETED
Conditions: Dynapenia|Obesity
Interventions: BEHAVIORAL: Weight Loss|DIETARY_SUPPLEMENT: Dairy Protein|BEHAVIORAL: Low intensity exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol
Status: RECRUITING
Conditions: Asthma|Cough|Cough Variant Asthma
Interventions: DRUG: Methacholine (MCh) Challenge Testing|DIAGNOSTIC_TEST: Eucapneic Voluntary Hyperventilation (EVH)|DRUG: Mannitol Inhalation Kit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: GSK3640254 First Time in Human (FTIH) Study in Healthy Volunteers
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus|HIV Infections
Interventions: DRUG: GSK3640254|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radical Local vs. Palliative Therapy for Breast Cancer Patientts With Ipsilateral Humerus or Sternum Oligometastasis
Status: RECRUITING
Conditions: Breast Cancer|Oligometastasis
Interventions: PROCEDURE: Radical resection|RADIATION: Radical radiotherapy|OTHER: Palliative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of CNTO 328 and Bortezomib to Bortezomib Alone in Patients With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: Siltuximab|DRUG: Bortezomib|DRUG: Placebo|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Vincristine Sulfate Liposome Injection (Marqibo®) in Combination With UK ALL R3 Induction Chemotherapy for Children, Adolescents, and Young Adults With Relapsed ALL
Status: UNKNOWN
Conditions: ALL, Childhood|Lymphoblastic Leukemia, Acute, Childhood|Lymphoblastic Leukemia, Acute
Interventions: DRUG: Marqibo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Function Using Non-invasive Forced Oscillometry
Status: RECRUITING
Conditions: Infant, Premature, Diseases|Infant, Newborn, Diseases|Bronchopulmonary Dysplasia|Respiratory Distress Syndrome, Newborn|Meconium Aspiration Syndrome|Transient Tachypnea of the Newborn
Interventions: DEVICE: Non-invasive forced airway oscillometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 1b / 2 Drug Resistant Immunotherapy With Activated, Gene Modified Allogeneic or Autologous γδ T Cells (DeltEx) in Combination With Maintenance Temozolomide in Subjects With Recurrent or Newly Diagnosed Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma
Interventions: BIOLOGICAL: Autologous genetically modified gamma-delta T cells|BIOLOGICAL: Allogeneic genetically modified gamma-delta T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Safety and Immunogenicity Study for an Anthrax Vaccine Using 3 Schedules and Two Dose Levels
Status: COMPLETED
Conditions: Anthrax
Interventions: BIOLOGICAL: AV7909|BIOLOGICAL: BioThrax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of SPN-812 (Viloxazine Extended-release Capsule) High Dose in Children With ADHD
Status: COMPLETED
Conditions: ADHD
Interventions: DRUG: Placebo|DRUG: 200mg SPN-812|DRUG: 400mg SPN-812
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of the Effect of Topical Bromfenac Ophthalmic Solution 0.09%in Patients With Acute Post-operative Cystoid Macular Edema.
Status: WITHDRAWN
Conditions: Cystoid Macular Edema
Interventions: DRUG: Bromfenac (Xibrom)|DRUG: Refresh Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Propofol-Ketamine vs Remifentanyl-Ketamine for Sedation in Pediatric Patients Undergoing Colonoscopy
Status: COMPLETED
Conditions: Delayed Emergence From Anesthesia
Interventions: DRUG: Remifentanyl|DRUG: Propofol|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Raised Intracranial Pressure Using MR Elastography
Status: RECRUITING
Conditions: Idiopathic Intracranial Hypertension
Interventions: DIAGNOSTIC_TEST: MR elastography|DIAGNOSTIC_TEST: MRI structural brain imaging|PROCEDURE: Lumbar puncture|DIAGNOSTIC_TEST: Optical Coherence Tomography (OCT) imaging|DIAGNOSTIC_TEST: Optic nerve B-scan ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Clinical Study of T3011 in Combination With PD-1/PD-L1 Inhibitors in Subjects With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: BIOLOGICAL: T3011 high dose|BIOLOGICAL: T3011 middle dose|BIOLOGICAL: T3011 low dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid Free Management After Ureteroscopy
Status: COMPLETED
Conditions: Kidney Stone
Interventions: DRUG: Norco 5milligram-325milligram Tablet|DRUG: Ibuprofen 400 MILLIGRAM in 1 TABLET ORAL TABLET, FILM COATED
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment Of Knee Osteoarthritis With Intra-Articular Infliximab
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: Infliximab|DRUG: Placebo|DRUG: Standard of Care: Methylprednisolone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fatigability in Persons With Multiple Sclerosis: Inputs From Cognition, Walking and Coordination
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Dance therapy|OTHER: Psychometric properties (Validity, Reliability) of interlimb coordination- and cognitive-fatigability
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Saline Linked Monopolar Surface Radiofrequency (RF) Ablation of Hepatic Tumors
Status: COMPLETED
Conditions: Malignant Liver Tumors|Liver Metastases From Colorectal Cancer
Interventions: PROCEDURE: RF Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Healthy Volunteer Study to Evaluate the Ability of PRT064445 to Reverse the Effects of Several Blood Thinner Drugs on Laboratory Tests (Module 4 of 4)
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: COMBINATION_PRODUCT: PRT064445/Edoxaban|COMBINATION_PRODUCT: Placebo/Edoxaban|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin Supplementation in NSCLC Patients on Pemetrexed Based Chemotherapy
Status: COMPLETED
Conditions: Lung Adenocarcinoma|Neutropenia|Anemia|Thrombocytopenia|Nonsquamous Nonsmall Cell Neoplasm of Lung
Interventions: DIETARY_SUPPLEMENT: Folate and B12
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Relative Bioavailability Study of Setrobuvir Tablet Formulation Versus Reference Setrobuvir Capsule Formulation in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: setrobuvir|DRUG: setrobuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Surgical Eradication of Deep Infiltrating Endometriosis of the Vagina
Status: COMPLETED
Conditions: Endometriosis
Interventions: PROCEDURE: longitudinal suture|PROCEDURE: transverse suture|PROCEDURE: Removal of vaginal endometriotic nodule
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Oral Carbohydrate on Gastric Emptying
Status: RECRUITING
Conditions: Vomit Aspiration|Anxiety
Interventions: DIETARY_SUPPLEMENT: Preoperative carbohydrate solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TAS-102 and Irinotecan in 2L+ Gastric and Gastroesophageal Adenocarcinoma
Status: COMPLETED
Conditions: Gastric Adenocarcinoma|GastroEsophageal Cancer
Interventions: DRUG: TAS-102|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Humanized Anti-Interferon-γ Monoclonal Antibody (HuZAF) for Moderate to Severe Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease|Colitis|Intestinal Disease|Gastrointestinal Disease|Digestive System Disease
Interventions: DRUG: anti-Interferon-gamma monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Hypnosis Mask: a New Approach to Management of Pain in Medical Imaging
Status: UNKNOWN
Conditions: Prostatic Diseases
Interventions: PROCEDURE: Periprostatic nerve block|DEVICE: hypnosis mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Fresh Mango Consumption on Cardiometabolic Outcomes in Free-living Individuals With Prediabetes
Status: RECRUITING
Conditions: Hyperglycemia|Dyslipidemias|Insulin Resistance|Inflammation|Oxidative Stress
Interventions: BEHAVIORAL: Mango
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trends and Safety in Revisional Bariatric Surgery in Italy
Status: UNKNOWN
Conditions: Obesity, Morbid|Bariatric Surgery Candidate|Remission|Complication,Postoperative|Complication of Surgical Procedure|Safety Issues
Interventions: PROCEDURE: revisional bariatric surgical procedures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Operative Versus Non-operative Treatment for Mild to Moderate Hallux Valgus Deformity
Status: NOT_YET_RECRUITING
Conditions: Hallux Valgus Deformity
Interventions: OTHER: Conservative treatment with orthopedic aid/wide shoe for participants with mild to moderate hallux valgus|OTHER: Operation for mild to moderate hallux valgus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Feasibility and Effectiveness of a Remote Monitoring Program for the Treatment of Diabetic Foot Ulcers
Status: RECRUITING
Conditions: Diabetic Foot|Diabetic Foot Ulcer|Wound; Foot|Wound Leg|Wound Heal|Diabetes Complications
Interventions: OTHER: Remote wound monitoring technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pulmonary and Extrapulmonary Impacts of COVID-19 on Young Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Post COVID-19
Interventions: OTHER: Evaluation of Pulmonary and Extrapulmonary Impacts of COVID-19 on Young Adults
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Alkaline Diet for Insulin Sensitivity
Status: COMPLETED
Conditions: Dysglycemia|Type 2 Diabetes Mellitus
Interventions: DRUG: Sodium Bicarbonate Oral Capsule|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Extracorporeal Shock Wave Therapy Added To Complex DecongestiveTherapy In Patıent With Lymphedeme
Status: RECRUITING
Conditions: Lymphedema, Breast Cancer
Interventions: DEVICE: Ekstracorporeal Shock Wave Therapy (ESWT)|OTHER: complex decongestive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Treatment Modalities in Esophageal Cancer
Status: RECRUITING
Conditions: Esophageal Cancer|Chemotherapy Effect|Chemoradiation|Surgery|Targeted Therapy|Immunotherapy|Esophagogastric Juction Cancer
Interventions: DRUG: Platinum based chemotherapy|DRUG: Paclitaxel based chemotherapy|RADIATION: Radiotherpay|PROCEDURE: Surgery|DRUG: Immunotherapy|DRUG: 5-FU Analog based chemotherpay|DRUG: Nimotuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted Navigation in Hepatocellular Carcinoma (HCC)
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Cholangiocarcinoma|Hepatobiliary Cancer
Interventions: BEHAVIORAL: Target Navigation Pilot Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment of High Dose Transdermal Nicotine for Fast Metabolizers of Nicotine
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: DRUG: Nicoderm CQ transdermal nicotine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Pembrolizumab Plus Androgen Axis Blockade Prior to Prostatectomy for High Risk Localized Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Energy Labelling for Alcohol Drinks in New Zealand: Consumers Perceptions and Impacts on Purchase Behaviour
Status: COMPLETED
Conditions: Consumption, Alcohol|Drinking, Alcohol
Interventions: BEHAVIORAL: Intervention|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Up-front Matched Unrelated Donor Transplantation in Pediatric Patients With Idiopathic Aplastic Anemia
Status: NOT_YET_RECRUITING
Conditions: Idiopathic Aplastic Anemia|Severe Aplastic Anemia|Moderate Aplastic Anemia Requiring Transfusions
Interventions: OTHER: HSCT Arm group
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Immunohistopathologic Findings of Cesarean Scar Niche
Status: RECRUITING
Conditions: Cesarean Scar Niche
Interventions: PROCEDURE: hysteroscopic resection of lower edge of cesarean scar niche
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase III Trial of Recombinant Human Apo-2 Ligand for Injection
Status: UNKNOWN
Conditions: Non-small-cell Lung Cancer (NSCLC) Stage IV
Interventions: BIOLOGICAL: Recombinant human Apo-2 ligand for Injection|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism
Status: UNKNOWN
Conditions: Systolic Heart Failure|Sub-clinical Hypothyroidism
Interventions: DRUG: Levothyroxine supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Safety, Tolerability and Pharmakinetics When Giving Single and Fractionated Doses of AZD3241 to Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: AZD3241|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: INHALE-3: Afrezza® Combined With Insulin Degludec Versus Usual Care in Adults With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: BIOLOGICAL: Afrezza|BIOLOGICAL: insulin degludec|BIOLOGICAL: Rapid-acting Insulin Analog|BIOLOGICAL: Basal Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 2-HOBA Phase 2 Clinical Trial in Rheumatoid Arthritis
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: 2-HOBA|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of BGB-11417 Monotherapy in Participants With Relapsed or Refractory Mantle Cell Lymphoma
Status: RECRUITING
Conditions: Mantle Cell Lymphoma|Refractory Mantle Cell Lymphoma (MCL)|Relapsed Mantle Cell Lymphoma
Interventions: DRUG: BGB-11417
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of PTK787/ZK222584 to Treat Metastatic Neuroendocrine Tumors
Status: COMPLETED
Conditions: Metastatic Neuroendocrine Tumors
Interventions: DRUG: vatalanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Different Techniques for Carotid Artery Endarterectomy
Status: RECRUITING
Conditions: Carotid Stenosis|Carotid Atherosclerosis|Carotid Artery Plaque
Interventions: PROCEDURE: carotid endarterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on the EBV CAR-T /TCR-T Cells in the Treatment of Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: BEHAVIORAL: PK Blood Collection|DRUG: CAR|DRUG: TCR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tacrolimus Microsampling
Status: COMPLETED
Conditions: Validate Volumetric Absorptive Microsampling (VAMS) Assay
Interventions: DEVICE: Mitra Microsampler
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Noninvasive Peripheral Nerve Stimulation for Restless Legs Syndrome During Opioid Medication Reduction
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DEVICE: Noninvasive Peripheral Nerve Stimulation (NPNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Hyperuricemia With Rasburicase in Patients With Acute Lymphoblastic Leukemia or High Grade Lymphoma
Status: COMPLETED
Conditions: Adult Acute Lymphocytic Leukemia|High-grade Lymphoma
Interventions: DRUG: Allopurinol|DRUG: Rasburicase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy and Light Therapy
Status: COMPLETED
Conditions: Pulmonary Hypertension|Insomnia|Fatigue
Interventions: BEHAVIORAL: CBT-I|DEVICE: Bright Light Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open Label Phase II Study of Biweekly Docetaxel Plus Androgen-Deprivation Therapy in Patients With Previously-Untreated, Metastatic, Prostatic Adenocarcinoma
Status: UNKNOWN
Conditions: Prostatic Neoplasm
Interventions: DRUG: Docetaxel|OTHER: Androgen-Deprivation Therapy (ADT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Harnessing the Healthy Gut Microbiota to Cure Patients With Recurrent C. Difficile Infection
Status: TERMINATED
Conditions: Clostridium Difficile Infection
Interventions: BIOLOGICAL: "synthetic stool" or pure cultures of probiotic intestinal bacteria
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Front-of-package Warning Labels on Perceived Weight Stigmatization
Status: COMPLETED
Conditions: Weight Stigma
Interventions: BEHAVIORAL: Nutrient warning labels|BEHAVIORAL: Text-only health warning labels|BEHAVIORAL: Graphic health warning labels|BEHAVIORAL: Control labels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Aripiprazole as an Adjunctive Therapy in Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Aripiprazole (Fixed dose)|DRUG: Aripiprazole (Titrated dose)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the RelayPro Thoracic Stent-Graft in Subjects With an Acute, Complicated Type B Aortic Dissection
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Dissection Type B
Interventions: DEVICE: Relay Pro Stent-Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Effects of Fenofibrate Adjuvant Therapy Versus Conventional Phototherapy in Neonatal Jaundice.
Status: NOT_YET_RECRUITING
Conditions: Physiological Neonatal Jaundice|Physiological Hyperbilirubinaemia
Interventions: DRUG: Fenofibrate|DEVICE: Phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MAVERICK™ Total Disc Replacement- Pivotal Study
Status: COMPLETED
Conditions: Spinal Diseases
Interventions: DEVICE: MAVERICK™ Disc|DEVICE: LT-CAGE® Lumbar Tapered Fusion Device and INFUSE® Bone Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Staging Classification of Severe Tricuspid Regurgitation Using Novel Cardiac Imaging Techniques
Status: ACTIVE_NOT_RECRUITING
Conditions: Tricuspid Regurgitation
Interventions: DIAGNOSTIC_TEST: Cardiac Magnetic Resonance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Docetaxel and Oxaliplatin in Metastatic Transitional Cell Cancer (TCC) of the Urothelial Tract
Status: COMPLETED
Conditions: Metastatic Transitional Cell Cancer of the Urothelial Tract
Interventions: DRUG: Docetaxel|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Effect of Zinc in Atorvastatin Treated Hyperlipidemic Patients
Status: UNKNOWN
Conditions: Hyperlipidemias
Interventions: DRUG: Zinc sulfate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Communication in Older Cancer Patients and Their Caregivers
Status: COMPLETED
Conditions: Adult Solid Neoplasm|Lymphoma
Interventions: BEHAVIORAL: Geriatric Assessment Summary|BEHAVIORAL: Geriatric Assessment Targeted Recommendations|BEHAVIORAL: Geriatric Assessment (GA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Couples' QOL in Metastatic Breast Cancer
Status: RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: BEHAVIORAL: Adapted Intimacy Enhancement|BEHAVIORAL: Intimacy Facts and Resources
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Multicenter, Phase 3 Study of IBI343 Monotherapy Versus Treatment of Investigator's Choice in Subjects With Previously Treated, Claudin (CLDN) 18.2-positive, HER2-negative, Gastric or Gastroesophageal Junction Adenocarcinoma
Status: ENROLLING_BY_INVITATION
Conditions: Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: irinotecan|DRUG: IBI343|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thymoglobulin Versus Campath-1H Versus Daclizumab in Adult, Primary Living Donor Renal Transplantation
Status: COMPLETED
Conditions: Living-Donor Kidney Transplant
Interventions: DRUG: Thymoglobulin|DRUG: Campath-1H|DRUG: Daclizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Saphenous Nerve Block Versus Femoral Nerve Block for Total Knee Arthroplasty
Status: COMPLETED
Conditions: Total Knee Arthroplasty
Interventions: PROCEDURE: Study Group: Experimental|PROCEDURE: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Health and Adverse Pregnancy Complications
Status: RECRUITING
Conditions: Periodontal Diseases|Pregnancy Complications|Pregnancy Preterm|Gestational Diabetes|Preeclampsia|Inflammation
Interventions: OTHER: Periodontal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT