pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Targeting Inflammation to Treat Cardiovascular Aging
Status: COMPLETED
Conditions: Vascular Stiffness|Endothelial Dysfunction|Diastolic Dysfunction
Interventions: DRUG: Salsalate|DRUG: Placebo (for salsalate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Perioperative Iron Isomaltoside 1000 Administration on Transfusion Requirements in Patients Undergoing Complex Valvular Heart Surgery: a Randomized Clinical Trial
Status: COMPLETED
Conditions: Complex Valvular Heart Surgery
Interventions: DRUG: iron isomaltoside 1000 (Monofer®)|DRUG: normal saline 100 ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Manual Lymphatic Drainage Breast Massage in Breast Cancer Patients After Breast Conserving Surgery
Status: RECRUITING
Conditions: Anatomic Stage 0 Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Localized Breast Carcinoma
Interventions: OTHER: Lymphedema Management|OTHER: Questionnaire Administration|RADIATION: Adjuvant breast radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Statin Combined With Amlodipine Treats Primary Aldosteronism
Status: NOT_YET_RECRUITING
Conditions: Primary Aldosteronism|Statin|Mineralocorticoid Receptor Antagonist|Hypertension
Interventions: DRUG: Simvastatin combined with Amlodipine besylate|DRUG: Simvastatin combined with Spironolactone and Amlodipine besylate.|DRUG: Amlodipine besylate combined Spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antiretroviral Therapy Selection: Comparing HIV Clinical Guidelines With HIV-ASSIST, an Online Decision-support Tool
Status: COMPLETED
Conditions: Hiv
Interventions: BEHAVIORAL: HIV-ASSIST|BEHAVIORAL: DHHS guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of a Citrate-based Anticoagulation With Calcium-free Phosphate-containing Fluid in Renal Replacement Therapy
Status: UNKNOWN
Conditions: Critical Care
Interventions: DRUG: Biphozyl (dialysate and replacement)|DRUG: Prismocal B22 (dialysate) + phoxilium (replacement)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Advanced Reperfusion Strategies for Refractory Cardiac Arrest
Status: TERMINATED
Conditions: Cardiac Arrest|Extracorporeal Membrane Oxygenation Complication|Ventricular Fibrillation|Pulseless Ventricular Tachycardia|Out-Of-Hospital Cardiac Arrest
Interventions: DEVICE: Early Extracorporeal Membrane Oxygenation (ECMO) Facilitated Resuscitation|DEVICE: Standard Advanced Cardiac Life Support (ACLS) Resuscitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of His Bundle Pacing and Bi-Ventricular Pacing in Heart Failure With Atrial Fibrillation
Status: UNKNOWN
Conditions: Heart Failure|Atrial Fibrillation
Interventions: DEVICE: CRT Device and Bi-ventricular pacing|DEVICE: CRT Device and His-bundle Pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Intranasal Epinephrine After Administration of ARS -1 in Subjects With Frequent Urticaria Flares
Status: COMPLETED
Conditions: Urticaria
Interventions: DRUG: ARS-1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment and Clinical Outcomes Among SLE Patients in Pregnancy
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus|Pregnancy Related
Interventions: DRUG: Anticoagulation|DRUG: Without Anticoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy and Safety Evaluation of Irbesartan High and Amlodipine Combined Therapy in Essential Hypertension Patients
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Irbesartan/Amlodipine|DRUG: Irbesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Of Oral Trehalose In Spinocerebellar Ataxia 3
Status: UNKNOWN
Conditions: Spinocerebellar Ataxia Type 3
Interventions: DIETARY_SUPPLEMENT: Trehalose|DIETARY_SUPPLEMENT: Maltose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Analgesic Effect of 2 Shoulder Infiltrations
Status: RECRUITING
Conditions: Infiltration|Shoulder Osteoarthritis
Interventions: DRUG: Triamcinolone Hexacetonide and hyaluronic acid|DRUG: Triamcinolone Hexacetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Dexmedetomidine on Brain Homeostasis and Neurocognitive Outcome
Status: COMPLETED
Conditions: Brain Tumor|Metabolic Disturbance|Inflammatory Response|Oxygen Deficiency
Interventions: DRUG: Dexmedetomidine|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Preparedness for Pelvic Organ Prolapse Surgery
Status: COMPLETED
Conditions: Pelvic Organ Prolapse|Patient Preparedness
Interventions: OTHER: Preoperative counseling office visit|OTHER: Preoperative counseling phone call
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: NFX-179 Topical Gel Treatment in Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF)
Status: COMPLETED
Conditions: Neurofibromatosis 1|Cutaneous Neurofibroma
Interventions: DRUG: NFX-179 Gel|DRUG: Vehicle Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Efficacy of Toreforant (JNJ-38518168) in Participants With Moderate to Severe Plaque-type Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: JNJ-38518168 60 mg|DRUG: JNJ-38518168 30 mg|DRUG: JNJ-38518168 3 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Electrostimulation, Skeletal Muscle Function, and Exercise Capacity in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DEVICE: Electrostimulation|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance (MR) Imaging With Hyperpolarized Bicarbonate (13C) to Measure Tissue pH in Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer|Localized Prostate Carcinoma
Interventions: DRUG: Hyperpolarized Bicarbonate (13C)|PROCEDURE: Magnetic Resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: GP2013 in the Treatment of Patients With Previously Untreated, Advanced Stage Follicular Lymphoma (ASSIST_FL)
Status: COMPLETED
Conditions: Follicular Lymphoma
Interventions: BIOLOGICAL: GP2013|BIOLOGICAL: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of High-Dose Chemotherapy With Bone Marrow or Stem Cell Transplant for Rare Poor-Prognosis Cancers
Status: COMPLETED
Conditions: Wilms Tumor|Fibrosarcoma|Carcinoma, Round Cell|Nasopharyngeal Cancer|Brain Tumor, Recurrent
Interventions: PROCEDURE: Myeloablative Chemotherapy|PROCEDURE: Stem Cell Rescue
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ENDO GIA™ Stapler With ENDO GIA™ Reload With Tri-Staple™ Technology in a Pulmonary Resection
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DEVICE: ENDO GIA™ Stapler with TRI-STAPLE™ Technology
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sirolimus for Improving Social Abilities in People With PTEN Germline Mutations
Status: WITHDRAWN
Conditions: PTEN Gene Mutation|PTEN Hamartoma Tumor Syndrome|PTEN Hamartoma Syndrome
Interventions: DRUG: Sirolimus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Recurrence After Whipple's (RAW) Study
Status: COMPLETED
Conditions: Pancreatic Cancer|Ampullary Cancer|Bile Duct Cancer|Cholangiocarcinoma, Extrahepatic|Cholangiocarcinoma Resectable|Cholangiocarcinoma of the Extrahepatic Bile Duct|Pancreatic Ductal Adenocarcinoma|Pancreatic Ductal Carcinoma|Surgery|Survivorship|Recurrent Cancer|Cancer Recurrent|Cancer Recurrence|Local Recurrence of Malignant Tumor of Pancreas
Interventions: PROCEDURE: Pancreaticoduodenectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized, Two-way, Crossover Study to Estimate the Relative Bioavailability of a Controlled-release Formulation of Oxycodone (40 mg) With Sequestered Naltrexone Compared With Immediate-release Oxycodone Tablets (20 mg) in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxycodone controlled-release test formulation|DRUG: Immediate-release reference drug
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preimplantation Genetic Screening in Patients With Male Factor Infertility
Status: UNKNOWN
Conditions: Infertility, Male|Diagnosis, Preimplantation
Interventions: PROCEDURE: ICSI without PGS|PROCEDURE: ICSI with PGS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Prompt to Bundle COVID-19 Booster and Flu Shot
Status: RECRUITING
Conditions: COVID-19|Vaccines
Interventions: BEHAVIORAL: Reminder to boost protection against COVID-19|BEHAVIORAL: Flu Tag Along|BEHAVIORAL: COVID-19 Booster & Flu Bundle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Assessing the Feasibility of Economic Approaches to Prevent Substance Abuse Among Adolescents
Status: COMPLETED
Conditions: Adolescent Drinking|HIV/AIDS|Drug Use
Interventions: BEHAVIORAL: Economic Empowerment Intervention|BEHAVIORAL: Alcohol and Drug Use Risk Reduction Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Belimumab for the Treatment of Diffuse Cutaneous Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis
Interventions: DRUG: Belimumab|DRUG: Mycophenolate Mofetil|OTHER: Placebo Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Capecitabine With or Without Irinotecan Driven by UGT1A1
Status: UNKNOWN
Conditions: Locally Advanced Rectal Cancer
Interventions: RADIATION: Radiation|DRUG: Capecitabine|DRUG: Irinotecan|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Randomized, Double-blind, Placebo-controlled, Single and Multiple Dose Escalation Study in Healthy Subjects
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: SHR-1819|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Dietary Supplementation on Dynamic Stability
Status: WITHDRAWN
Conditions: Aging
Interventions: DIETARY_SUPPLEMENT: (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Variations in Palatability and Portion Size of Vegetables on Meal Intake of Preschool Children
Status: COMPLETED
Conditions: Feeding Behavior
Interventions: OTHER: Plain Vegetables Served in 100% Portion Size|OTHER: Plain Vegetables Served in 200% Portion Size|OTHER: Enhanced Vegetables Served in 100% Portion Size|OTHER: Enhanced Vegetables Served in 200% Portion Size
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Personalized Shoe Insole on the Gait of Parkinson's Disease Subjects
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DEVICE: Custom-made shoe insole|DEVICE: Sham conventional Insole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Three Distraction Methods for Pain Reduction During Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy|Colon Disease
Interventions: OTHER: Music group|OTHER: Stress ball group|OTHER: Video group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomized, Double-Blind, Controlled Trial to Assess the Efficacy of a Fortetropin Supplement in Improving Symptoms of Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: OTHER: Fortetropin supplement|OTHER: Cheese protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: An Extension Study of ABBV-8E12 in Progressive Supranuclear Palsy (PSP)
Status: TERMINATED
Conditions: Progressive Supranuclear Palsy (PSP)
Interventions: DRUG: ABBV-8E12|DRUG: Placebo solution for IV infusion on Day 15
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-Label Phase 1 Study of Aerosolized Amikacin and Fosfomycin in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: amikacin/fosfomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Intensive Goal Training With Educational Strategies for Adolescents With Cerebral Palsy
Status: NOT_YET_RECRUITING
Conditions: Cerebral Palsy
Interventions: OTHER: Individualized goal training|OTHER: Individualized goal training with educational strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Self-screening of Cognitive Impairment in Primary Care
Status: WITHDRAWN
Conditions: Cognition Disorder|Alzheimer Disease
Interventions: OTHER: MMSE (mini mental state examination)|OTHER: SAGE (Self-Administered Gerocognitive Exam)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Lot-to-lot Consistency Trial of Japanese Encephalitis Live Attenuated SA 14-14-2 Vaccine
Status: COMPLETED
Conditions: Japanese Encephalitis
Interventions: BIOLOGICAL: Vaccine produced in existing facility|BIOLOGICAL: Vaccine produced in new facility
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Dose Confirmation and Safety of Crizanlizumab in Pediatric Sickle Cell Disease Patients
Status: RECRUITING
Conditions: Sickle Cell Disease (SCD)
Interventions: DRUG: Crizanlizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of Microneedling and Injectable Platelet Rich Fibrin in Thin Periodontal Phenotype
Status: UNKNOWN
Conditions: Thin Gingiva
Interventions: PROCEDURE: Microneedling|PROCEDURE: injectable- platelet rich fibrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Two Levels of Frequency of Repositioning in the Reduction of Pressure Ulcers
Status: COMPLETED
Conditions: Critical Illness
Interventions: OTHER: High frequency postural change|OTHER: Conventional care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Generating Evidence in ECMO Ventilation Strategies
Status: RECRUITING
Conditions: ARDS|Acute Respiratory Failure
Interventions: OTHER: Standard-Lung Protective Ventilation|OTHER: Ultra-Lung Protective Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: 2D Speckle-tracking Echocardiography in Chemotherapy-induced Cardiomyopathy With Cardiovascular Risk Factors
Status: UNKNOWN
Conditions: Cardiomyopathy Due to Drug|Breast Cancer|Cardiovascular Risk Factor
Interventions: DIAGNOSTIC_TEST: Echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Innovation in the Treatment of Persistent Pain in Adults With NF1: Implementation of the iCanCope Mobile Application- Clinical Trial
Status: COMPLETED
Conditions: Neurofibromatosis 1|Chronic Pain
Interventions: DEVICE: iCanCope|DEVICE: iCanCope+Contingency Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: RETRIEVE-AMI Study
Status: RECRUITING
Conditions: Myocardial Infarction|Thrombus|Coronary Artery Disease
Interventions: DEVICE: Retriever Thrombectomy|PROCEDURE: Percutaneous Coronary Intervention|PROCEDURE: Thrombus Aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: capecitabine|DRUG: irinotecan hydrochloride|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketogenic Diet and Diabetes Demonstration Project
Status: RECRUITING
Conditions: Type 2 Diabetes|PreDiabetes|Obesity|Ketogenic Dieting
Interventions: BEHAVIORAL: Ketogenic diet|BEHAVIORAL: Low Fat diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaginal Ecosystem and Network in the United States Study
Status: RECRUITING
Conditions: Bacterial Vaginosis|Candidiasis|Urinary Tract Infections|Genitourinary Syndrome of Menopause|Lichen Sclerosus|Lichen Planus|Vulvodynia|Endometriosis|Ureaplasma Infections|Cancer|Desquamative Inflammatory Vaginitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Decentering and Relapse/Recurrence in MBCT for Depression in Adults
Status: COMPLETED
Conditions: Depression|Depressive Disorder, Major|Depression in Remission
Interventions: BEHAVIORAL: Mindfulness-based Cognitive Therapy (MBCT)|BEHAVIORAL: Relaxation Group Therapy (RGT)|BEHAVIORAL: Treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of Near-infrared Fluorescence Imaging Use as a Supportive Tool in Deep Infiltrating Endometriosis Surgery
Status: COMPLETED
Conditions: Pelvic Endometriosis|Endometriosis Outside Pelvis
Interventions: DRUG: Indocyanine Green
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dashboard Activated Services and Tele-Health for Heart Failure
Status: COMPLETED
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: OTHER: Proactive Panel Management Clinics for HFrEF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cognitive Impairment Related to Atrial Fibrillation Prevention Trial
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Warfarin|DRUG: Dabigatran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fasted Bioequivalence Study of Primidone Tablets and Mysoline Tablets
Status: COMPLETED
Conditions: Therapeutic Equivalency
Interventions: DRUG: Primidone 50 mg Tablet|DRUG: Primidone (Mysoline®) 50 mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neoadjuvant and Adjuvant Capecitabine and Oxaliplatin in Treating Patients With Resectable Liver Metastases Secondary to Colorectal Cancer
Status: TERMINATED
Conditions: Liver Metastases|Recurrent Colon Cancer|Recurrent Rectal Cancer|Stage IV Colon Cancer|Stage IV Rectal Cancer
Interventions: DRUG: oxaliplatin|DRUG: capecitabine|PROCEDURE: therapeutic conventional surgery|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prebiotic Effect of Eicosapentaenoic Acid Treatment for Colorectal Cancer Liver Metastases
Status: RECRUITING
Conditions: Colon Cancer Liver Metastasis
Interventions: DRUG: Icosapent Ethyl Oral Capsule|OTHER: Placebo
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Physical ACtivity Enhancement Scheme (PACES) in Hemodialysis Patients
Status: COMPLETED
Conditions: Kidney Failure, Chronic|Exercise|Physical Activity|Renal Dialysis
Interventions: BEHAVIORAL: PACES intervention|OTHER: Usual care with sham intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Indacaterol on Inspiratory Capacity (IC)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Indacaterol|DRUG: Tiotropium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Natural Versus Artificial Cycle for Frozen-Thawed Embryo Transfer
Status: RECRUITING
Conditions: Embryo Transfer
Interventions: DRUG: Natural cycle|DRUG: Estradiol Valerate|DRUG: Micronized progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Critical Time Intervention in the Transition From Hospital to Community in People With Severe Mental Illness
Status: COMPLETED
Conditions: Psychotic Disorders
Interventions: BEHAVIORAL: Critical Time Intervention (CTI)|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Food First Approach to Stimulate Muscle Protein Synthesis in Healthy Adults
Status: COMPLETED
Conditions: Hypertrophy
Interventions: BEHAVIORAL: Resistance exercise|OTHER: Salmon|DIETARY_SUPPLEMENT: Isolated amino acids and fatty acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Population Pharmacokinetics of Antiretroviral in Children
Status: COMPLETED
Conditions: Minor Patient Treated by One or More Antiretroviral and for Which a Blood Test Has Been Performed
Interventions: BIOLOGICAL: Dolutegravir|BIOLOGICAL: Raltegravir|BIOLOGICAL: Rilpivirine|BIOLOGICAL: Nevirapine|BIOLOGICAL: Atazanavir|BIOLOGICAL: Darunavir|BIOLOGICAL: Ritonavir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Entire Papilla Preservation Technique With and Without Biomaterials in the Treatment of Isolated Intrabony Defects
Status: COMPLETED
Conditions: Periodontal Diseases
Interventions: PROCEDURE: Procedure: Periodontal surgery with entire papilla preservation (EPP) technique|DEVICE: EMD application|DEVICE: Bone substitutes application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Immunogenicity and Safety of mRNA Vaccine Boosters for SARS-CoV-2 (COVID-19) Variants
Status: COMPLETED
Conditions: SARS-CoV-2
Interventions: BIOLOGICAL: mRNA-1273.211|BIOLOGICAL: mRNA-1273|BIOLOGICAL: mRNA-1273.617.2|BIOLOGICAL: mRNA-1273.213|BIOLOGICAL: mRNA-1273.529|BIOLOGICAL: mRNA-1273.214|BIOLOGICAL: mRNA-1273.222|BIOLOGICAL: mRNA-1273.815|BIOLOGICAL: mRNA-1273.231
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of LY3039478 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Placebo|DRUG: LY3039478 original formulation|DRUG: LY3039478 new formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Desensitization Therapy and Re-treatment of Eye Movement Information [EMDR] in Patients With Post-traumatic Stress Disorder [PTSD]
Status: RECRUITING
Conditions: Post-traumatic Stress Disorder
Interventions: OTHER: Eye Movement Desensitization Reprocessing therapy|BEHAVIORAL: Trauma-Centred Cognitive and Behavioural Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Clinical Efficacy of Three Oral Hygiene Regimens Using a Manual Toothbrush, Toothpaste and a Mouthwash in Controlling Dental Plaque and Gingivitis
Status: COMPLETED
Conditions: Dental Plaque|Gingivitis
Interventions: DRUG: triclosan/fluoride toothpaste + cetylpyridinium chloride Mouthwash|DRUG: stannous fluoride toothpaste + cetylpyridinium chloride Mouthwash|DRUG: fluoride toothpaste + fluoride Mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Probiotic on Inflammation and Microbiota in Patients With NASH
Status: TERMINATED
Conditions: Non-Alcoholic Fatty Liver Disease|Probiotics MeSH Descriptor Data 2018|Interleukin-17 MeSH Descriptor Data 2018
Interventions: BIOLOGICAL: Probiotic Formulation VSL#3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fludarabine, Rituximab, and Alemtuzumab for B-Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Small Lymphocytic|Lymphocytic Leukemia, Chronic
Interventions: DRUG: Fludarabine|DRUG: Rituximab|DRUG: Alemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Assess Efficacy, Safety, and Tolerability of Rasagiline Mesylate 1 mg in Patients With Multiple System Atrophy of the Parkinsonian Subtype (MSA-P)
Status: COMPLETED
Conditions: Multiple System Atrophy
Interventions: DRUG: rasagiline mesylate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Functional Outcome in Patients After Hip Arthroplasty Depending on Surgical Approach
Status: COMPLETED
Conditions: Hip|Osteoarthritis
Interventions: PROCEDURE: Direct Anterior Approach (DAA)|PROCEDURE: Anterolateral approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioavailability Study of Leflunomide Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: To Determine the Bioequivalence Study Under Fasting
Interventions: DRUG: Leflunomide|DRUG: ARAVA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Exploring the Efficacy of Combined Task-Specific and Cognitive Strategy Training in Subacute Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: BEHAVIORAL: CO-OP|BEHAVIORAL: Standard Occupational Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of tDCS for Pain
Status: COMPLETED
Conditions: Pain, Chronic
Interventions: DEVICE: Transcranial Direct Current Stimulation(tDCS)|DEVICE: Sham Transcranial Direct Current Stimulation(sham tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Responses to Information on Treatments for Depression
Status: COMPLETED
Conditions: Depressive Symptoms
Interventions: OTHER: CBT without Personalization|OTHER: CBT with Personalization|OTHER: ADM without Personalization|OTHER: ADM with Personalization|OTHER: Combined Treatment without Personalization|OTHER: Combined Treatment with Personalization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of the Accelerated Traction of Impacted Canines in Terms of Speed and Changes in the Dental Arches
Status: COMPLETED
Conditions: Impacted Tooth With Abnormal Positioning
Interventions: PROCEDURE: Corticotomy|PROCEDURE: Traditional traction of the impacted canine without corticotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PrEP for Prevention of HIV Transmission Among People Who Inject Drugs in Nairobi, Kenya
Status: UNKNOWN
Conditions: HIV Antibody Positivity|PrEP Uptake
Interventions: BEHAVIORAL: Navigation into prEP by use of PrEP-UP intervention (provision of PrEP information through 5 counselling sessions, peer support, booking of appointments for PWIDs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Whey and Albumin Protein on Plasma Levels of Amino Acids
Status: COMPLETED
Conditions: Healthy Men and Women
Interventions: DIETARY_SUPPLEMENT: Whey Milk Protein|DIETARY_SUPPLEMENT: Bovine Albumin Concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Lubricating Gel on Patient Comfort During Speculum Insertion.
Status: COMPLETED
Conditions: Examination, Gynecological|Examination, Pelvic|Examination, Vaginal
Interventions: PROCEDURE: Lubricating gel used during speculum insertion.|PROCEDURE: Water used during speculum examination.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of phIL-12-005/PPC to Treat Recurrent Ovarian Cancer
Status: TERMINATED
Conditions: Ovarian Neoplasms
Interventions: GENETIC: EGEN-001 (phIL-12-005/PPC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Pharmacodynamics and Efficacy of Leuprolide Tablets (Ovarest®) in Women With Endometriosis
Status: UNKNOWN
Conditions: Endometriosis
Interventions: DRUG: Leuprolide Oral Tablet - 120 mg - QD- Treatment A|DRUG: Leuprolide Oral Tablet - 80 mg - QD - Treatment B|DRUG: Leuprolide Oral Tablet - 60 mg - QD - Treatment C|DRUG: Leuprolide Oral Tablet - 60 mg - BID - Treatment D|DRUG: Leuprolide Oral Tablet - 40 mg - BID - Treatment E
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thermosoftening of Double-lumen Tube to Reduce Sore Throat
Status: COMPLETED
Conditions: Hoarseness|Sore Throat|Vocal Cord Injuries
Interventions: PROCEDURE: non-thermosoftening|PROCEDURE: thermosoftening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dolutegravir/Lamivudine Dual Therapy for ART-naïve People With HIV and TB Receiving Rifampin-based TB Treatment
Status: NOT_YET_RECRUITING
Conditions: Tuberculosis|HIV
Interventions: DRUG: Dolutegravir 50mg Tab|DRUG: Dolutegravir/Lamivudine 50 MG-300 MG Oral Tablet [DOVATO]|DRUG: Dolutegravir plus Tenofovir disoproxil fumarate (TDF)/ lamivudine (3TC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Jin Si Herbal Tea on Cancer-related Fatigue of Gynecological Cancer Patients
Status: COMPLETED
Conditions: Cancer-related Fatigue|Gynecologic Cancer
Interventions: DIETARY_SUPPLEMENT: Jin Si Herbal Tea|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Building Evidence for Effective Palliative/End of Life Care for Teens With Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: BEHAVIORAL: FAmily CEntered Advance Care Planning for Teens with Cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effection of Total Knee Arthroplasty on Knee Joint
Status: RECRUITING
Conditions: Total Knee Arthroplasty
Interventions: DIAGNOSTIC_TEST: Total knee arthroplasty|DIAGNOSTIC_TEST: osteoarthritis without surgery|DIAGNOSTIC_TEST: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Response of Bony Metastasis to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancers With Actionable Driver Mutations.
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: BIOLOGICAL: Tyrosine Kinase Inhibitor|DRUG: Zoledronic Acid 4 MG/100 ML Intravenous Solution [ZOMETA]|DRUG: Denosumab 120 MG/1.7 ML Subcutaneous Solution [XGEVA]
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: COMPASSION S3 Post-Approval Study
Status: RECRUITING
Conditions: Complex Congenital Heart Defect|Dysfunctional RVOT Conduit|Pulmonary Valve Insufficiency|Pulmonary Valve Degeneration|Pulmonary Valve; Obstruction
Interventions: DEVICE: SAPIEN 3 THV
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Association of Apical Periodontitis With Systemic Level of Inflammatory Markers : A Longitudinal Intervention Study
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Apical Periodontitis
Interventions: PROCEDURE: endodontic treatment in the form of root canal treatment|PROCEDURE: endodontic treatment|DIAGNOSTIC_TEST: assessment of inflammatory marker|DIAGNOSTIC_TEST: inflammatory markers will be assessed along with metabolic markers assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of the CardioFocus Endoscopic Ablation System for the Treatment of Symptomatic AF
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: CardioFocus EAS-AC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medico-Economic Analysis of Management of Flail Chest Between Medical Treatment and Surgical Treatment With Stracos
Status: UNKNOWN
Conditions: Polytraumatises With Rib Fractures
Interventions: DEVICE: Thoracic osteosyntheses with Stracos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Niraparib Maintenance in HRD-Positive Advanced Ovarian Cancer Following Front-Line Chemotherapy + Bevacizumab
Status: RECRUITING
Conditions: Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma
Interventions: DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epanova® for Lowering Very High Triglycerides II (EVOLVE II)
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DRUG: Epanova|DRUG: Olive Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Micro vs. Standard Trabeculectomy Study
Status: UNKNOWN
Conditions: Glaucoma
Interventions: PROCEDURE: Standard Trabeculectomy|PROCEDURE: Microtrabeculectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-operative Sore Throat as Determined by Endotracheal Tube Inflation Technique
Status: COMPLETED
Conditions: Post Operative Sore Throat|Dysphagia|Hoarseness
Interventions: DEVICE: cuff manometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Pharmacological Study of OPC-41061 in the Treatment of Cardiac Edema (Congestive Heart Failure)
Status: COMPLETED
Conditions: Cardiac Edema
Interventions: DRUG: OPC-41061(Tolvaptan)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-finding Study of Moxidectin for Treatment of Scabies
Status: COMPLETED
Conditions: Scabies
Interventions: DRUG: Moxidectin Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Chemotherapy Plus RT and SHR-1210 to Treat Patients With ESCC
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: DRUG: SHR-1210|RADIATION: IMRT or VMAT|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Compare Adjuvant Chemotherapy, Chemoradiotherapy and Surgery Alone for pN1-2(pT1b-3N1-2M0) Esophageal Carcinoma
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: COMBINATION_PRODUCT: adjuvant treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Placebo-Controlled Study for SPM 962 in Restless Legs Syndrome (RLS) Patients
Status: COMPLETED
Conditions: Idiopathic Restless Legs Syndrome
Interventions: DRUG: SPM 962
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DuraMesh Laparotomy Closure Following Trauma and Emergency Surgery
Status: WITHDRAWN
Conditions: Hernia Incisional|Suture, Complication
Interventions: DEVICE: Duramesh Laparotomy Closure|DEVICE: Conventional suture closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Binimetinib With Docetaxel in Treating Patients With Previously Treated, Stage IV Non-small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Recurrent Non-Small Cell Lung Carcinoma|Stage IV Non-Small Cell Lung Cancer
Interventions: DRUG: Binimetinib|DRUG: Docetaxel|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label Study of Belimumab Plus Standard Therapy in Chinese Pediatric Participants With Active Systemic Lupus Erythematosus (SLE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Belimumab|DRUG: Standard therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Communication Tool to Assist Older Adults Facing Dialysis Choices
Status: ACTIVE_NOT_RECRUITING
Conditions: Palliative Care|Kidney Failure, Chronic|Decision Making|Decision Support Techniques|Renal Dialysis|Dialysis|Kidney Diseases|Nephrologists|Decision Aid|End of Life|End-Stage Renal Disease|Late-Stage Renal Disease|Communication|Life-Supporting Treatments
Interventions: OTHER: Best Case/Worst Case communication tool training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of the Efficacy and Safety of Quiklean® and Klean-Prep With Dulcolax® for the Bowel Preparation Prior to Colonoscopy
Status: COMPLETED
Conditions: Bowel Preparation
Interventions: DRUG: Quiklean® (sodium phosphate monobasic monohydrate, USP, and sodium phosphate dibasic anhydrous, USP)|DRUG: Polyethylene glycol 3350, sodium sulfate anhydrous, sodium bicarbonate, sodium chloride, potassium chloride, aspartame;Bisacodyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Test Albuvirtide in Experienced Patients
Status: COMPLETED
Conditions: HIV Infections|AIDS
Interventions: DRUG: albuvirtide|DRUG: lopinavir-ritonavir|DRUG: tenofovir|DRUG: lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study for a Multicentre Randomised Controlled Trial to Compare Surgery With Needle Ablation Techniques in People With Small Renal Masses (4cm)
Status: COMPLETED
Conditions: Renal Cancer
Interventions: PROCEDURE: Surgical treatment for renal mass|PROCEDURE: Percutaneous Radiofrequency ablation|PROCEDURE: Laparascopic or percutaneous cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Green (Sustainable) VENTOLIN - Pharmacokinetics (PK) Study in Healthy Participants
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Salbutamol HFA-152a|DRUG: Salbutamol HFA-134a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Determine PK Profiles of Ozanimod and Its' Major Metabolites in Healthy Subjects
Status: RECRUITING
Conditions: Multiple Sclerosis|Ulcerative Colitis
Interventions: DRUG: ZEPOSIA® indicated for the treatment of: Relapsing forms of multiple sclerosis, and active ulcerative colitis in adults
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Post Operative Nausea and Vomiting (PONV) Rescue Outcomes After Amisulpride Treatment
Status: WITHDRAWN
Conditions: Nausea and Vomiting, Postoperative
Interventions: DRUG: Rescue Post-Operative Nausea and Vomiting (PONV) treatment according to the standard of care (SOC)|DRUG: Amisulpride
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PET and/or MRI Scans in Assessing Tumor Response in Patients Receiving Antiangiogenesis Therapy
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: PROCEDURE: magnetic resonance imaging|PROCEDURE: positron emission tomography|RADIATION: fludeoxyglucose F 18
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: Regulation of Optic Nerve Head Blood Flow During Combined Changes in Intraocular Pressure and Arterial Blood Pressure
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Laser Doppler Flowmetry|DEVICE: Goldmann applanation tonometer|OTHER: squatting|DEVICE: Suction cup
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Correlation of Insulin Resistance With Hormonal and Ovarian Morphological Characteristics in Patients With Polycystic Ovarian Syndrome
Status: NOT_YET_RECRUITING
Conditions: Study the Relationship Between Insulin Resistance With Hormonal and Ovarian Morphological Characteristics in Patients With Polycystic Ovarian Syndrome
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p