pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Low GI Diet Effects on Non-Alcoholic Fatty Liver Disease
Status: UNKNOWN
Conditions: Fatty Liver|Nutritional and Metabolic Disease
Interventions: OTHER: low glycemic index diet|OTHER: High glycemic index diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Post Market Evaluation of Clinical Safety and Performance of the Fitbone Transport and Lengthening System
Status: NOT_YET_RECRUITING
Conditions: Fractures, Bone|Fractures, Closed|Fractures, Open|Fracture of Femur|Fracture Nonunion|Fracture of Tibia|Limb Deformity|Limb Fracture|Limb Defect|Limb Asymmetry
Interventions: DEVICE: Fitbone Transport and Lengthening System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hyperthermic Intraperitoneal Chemotherapy Trial Comparing Quality of Life in Patients With Stage IIIC-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Stage IIIC Fallopian Tube Cancer|Stage IIIC Ovarian Cancer|Stage IIIC Primary Peritoneal Cancer|Stage IV Fallopian Tube Cancer|Stage IV Ovarian Cancer|Stage IV Primary Peritoneal Cancer
Interventions: DRUG: Carboplatin|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Cytoreductive Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SBRT Plus Lenvatinib and TACE for Advanced Primary HCC: A Phase 3 Trial (SEARCH)
Status: NOT_YET_RECRUITING
Conditions: Advanced Hepatocellular Carcinoma
Interventions: DRUG: Lenvatinib|PROCEDURE: TACE|RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Golimumab in Rheumatoid Arthritis Participants With an Inadequate Response to Etanercept (ENBREL) or Adalimumab (HUMIRA)
Status: COMPLETED
Conditions: Arthritis|Arthritis, Rheumatoid|Autoimmune Diseases
Interventions: DRUG: Golimumab 50 mg SC|DRUG: Golimumab 2 mg/kg IV|DRUG: Methotrexate (MTX)|DRUG: Placebo SC|DRUG: Placebo IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ofatumumab for Patients With Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BMS-986253 in Combination With Nivolumab or Nivolumab Plus Ipilimumab in Advanced Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer|Melanoma
Interventions: DRUG: BMS-986253|BIOLOGICAL: Nivolumab|BIOLOGICAL: Ipilimumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dornase Alfa and Urokinase for Kids With Pleural Empyema
Status: UNKNOWN
Conditions: Pleural Empyema
Interventions: DRUG: Urokinase and Dornase alfa|DRUG: Urokinase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Sickle Cell Anemia With Stem Cell Transplant
Status: TERMINATED
Conditions: Sickle Cell Anemia|Sickle Cell-hemoglobin C Disease|Sickle Cell-β0-thalassemia
Interventions: DRUG: Fludarabine|DRUG: Cytarabine|DEVICE: Cellular Infusions|RADIATION: Total Body Irradiation|DRUG: Cyclophosphamide|DRUG: Bortezomib|DRUG: Rituximab|PROCEDURE: Plasmapheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Non-Surgical Periodontal Treatment in Women With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Gingivitis
Interventions: PROCEDURE: Non-surgical periodontal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phosphodiesterase-5 Inhibitor in Eisenmenger Syndrome
Status: COMPLETED
Conditions: Eisenmenger Syndrome
Interventions: DRUG: Tadalafil, placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LSALT Peptide for Prevention or Attenuation of Acute Kidney Injury (AKI) in Patients Undergoing On-Pump Cardiac Surgery
Status: RECRUITING
Conditions: Acute Kidney Injury|Cardiac Surgery
Interventions: DRUG: LSALT Peptide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Evaluation of Glass Ionomer With Glass Hybrid Technology Versus Conventional High Viscosity Glass Ionomer in Class I Cavities of High Caries Risk Patients
Status: UNKNOWN
Conditions: Class I Cavities in High Caries Risk
Interventions: OTHER: Conventional high viscosity glass ionomer|OTHER: Glass ionomer with glass hybrid technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Compare the Efficacy of Acupuncture Therapy and Carbamazepine Oral Dosage in Patients With Carpal Tunnel Syndrome by Multiple Excitability Test
Status: UNKNOWN
Conditions: Carpal Tunnel Syndrome|Multiple Excitability Test
Interventions: DRUG: Carbamazepine|PROCEDURE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anger Control Therapy (ACT) With RAGE-Control: An Outpatient Videogame-assisted Therapy for the Treatment of Anger
Status: UNKNOWN
Conditions: Anger|Aggression
Interventions: BEHAVIORAL: ACT|BEHAVIORAL: ACT with RAGE-Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer
Status: RECRUITING
Conditions: Locally Advanced Pancreatic Adenocarcinoma|Stage III Pancreatic Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|RADIATION: Hypofractionated Radiation Therapy|PROCEDURE: Magnetic Resonance Imaging|DRUG: Peposertib|OTHER: Placebo Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Below The Knee Arteries' Stenosis or Occlusion Treated With LEGFLOW OTW
Status: UNKNOWN
Conditions: Peripheral Artery Disease
Interventions: DEVICE: Paclitaxel Releasing Peripheral Balloon Dilatation Catheter|DEVICE: PTA catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of OmnEcoil System for Integrated Endorectal MRI and Transrectal MRI-Targeted Biopsy of the Prostate
Status: RECRUITING
Conditions: Prostate Carcinoma
Interventions: DEVICE: Biopsy|PROCEDURE: Endorectal Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Gastric Tube Reconstruction Widths on Quality of Life for Esophagogastric Cancers
Status: UNKNOWN
Conditions: Stomach Neoplasms|Esophageal Neoplasms
Interventions: PROCEDURE: esophagojejunostomy after total gastrectomy|PROCEDURE: Roux-en-Y gastrojejunostomy after subtotal gastrectomy|PROCEDURE: wide tube reconstruction after subtotal gastrectomy|PROCEDURE: narrow tube reconstruction after subtotal gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sonomyographic Upper Limb Prosthetics: A New Paradigm
Status: ENROLLING_BY_INVITATION
Conditions: Amputation|Prosthesis User
Interventions: DEVICE: Sonomyographic Prosthesis|DEVICE: Myoelectric direct control prosthesis|DEVICE: Myoelectric pattern recognition prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-operative Withdrawal of Aspirin in Laparoscopic Inguinal Hernia Repair
Status: RECRUITING
Conditions: Inguinal Hernia
Interventions: PROCEDURE: Laparoscopic inguinal hernia repair with perioperative Aspirin|PROCEDURE: Laparoscopic inguinal hernia repair without perioperative Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: 64Cu-GRIP B in Patients With Advanced Malignancies
Status: RECRUITING
Conditions: Prostate Cancer|Renal Cancer|Urethral Cancer|Advanced Solid Tumor|Metastatic Castration-resistant Prostate Cancer|Solid Tumor, Adult
Interventions: DRUG: Copper-64 labeled Granzyme B (64Cu-GRIP B)|PROCEDURE: Positron Emission Tomography (PET)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Clinical Stage III Cutaneous Melanoma AJCC v8|Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8|Clinical Stage IV Cutaneous Melanoma AJCC v8|Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8|Metastatic Basal Cell Carcinoma|Metastatic Melanoma|Metastatic Merkel Cell Carcinoma|Metastatic Skin Squamous Cell Carcinoma|Pathologic Stage III Cutaneous Melanoma AJCC v8|Pathologic Stage III Cutaneous Merkel Cell Carcinoma AJCC v8|Pathologic Stage IIIA Cutaneous Melanoma AJCC v8|Pathologic Stage IIIA Cutaneous Merkel Cell Carcinoma AJCC v8|Pathologic Stage IIIB Cutaneous Melanoma AJCC v8|Pathologic Stage IIIB Cutaneous Merkel Cell Carcinoma AJCC v8|Pathologic Stage IIIC Cutaneous Melanoma AJCC v8|Pathologic Stage IIID Cutaneous Melanoma AJCC v8|Pathologic Stage IV Cutaneous Melanoma AJCC v8|Pathologic Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8|Unresectable Basal Cell Carcinoma|Unresectable Melanoma|Unresectable Merkel Cell Carcinoma
Interventions: BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab|DRUG: Prednisone|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors
Status: COMPLETED
Conditions: Central Nervous System Embryonal Tumor With Rhabdoid Features|Central Nervous System Embryonal Tumor, Not Otherwise Specified|Central Nervous System Ganglioneuroblastoma|Embryonal Tumor With Multilayered Rosettes, C19MC-Altered|Pineoblastoma|Primary Central Nervous System Neoplasm|Recurrent Childhood Central Nervous System Embryonal Neoplasm|Recurrent Malignant Solid Neoplasm|Recurrent Medulloblastoma|Recurrent Neuroblastoma|Recurrent Rhabdomyosarcoma|Refractory Malignant Solid Neoplasm|Refractory Medulloblastoma|Refractory Neuroblastoma|Refractory Rhabdomyosarcoma
Interventions: DRUG: Adavosertib|DRUG: Irinotecan Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerance, PK and PD Parameters of GZR33 and GZR101 in Healthy Male Adult Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: GZR33 Injection|DRUG: GZR101 Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study of Iniparib as a Single Agent and in Combination in Solid Tumors
Status: COMPLETED
Conditions: Neoplasm Malignant
Interventions: DRUG: Iniparib (SAR240550-BSI-201)|DRUG: Gemcitabine|DRUG: Carboplatin|DRUG: Placlitaxel|DRUG: Pegylated liposomal doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fatty Acid Supplementation in Children With ASD (Study 2)
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DRUG: LCPUFA Oil Supplement|DIETARY_SUPPLEMENT: Canola Oil Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension
Interventions: DRUG: Olmesartan|DRUG: Amlodipine|DRUG: Indapamide|DRUG: Placebo|DRUG: Zilebesiran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Chlorhexidine Gel Following EDTA Root Surface Etching as an Adjunctive to Open Flap Debridement in Treating Intra-Bony Defects
Status: COMPLETED
Conditions: Periodontal Bone Loss
Interventions: PROCEDURE: CHX gel 2 % + 24% EDTA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MBRP on Reducing Craving and Addictive Behaviour in Adults
Status: RECRUITING
Conditions: Substance Abuse|Substance Use Disorders
Interventions: BEHAVIORAL: Mindfulness-based Relapses Prevention (MBRP)|BEHAVIORAL: Usual Care Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Venetoclax Plus IM2 Regimen for Relapsed and Refractory T Lymphoblastic Lymphoma/Leukemia
Status: RECRUITING
Conditions: T-lymphoblastic Lymphoma|Relapsed Disease|Refractory Lymphoma|Refractory Leukemia|Safety|Efficacy, Self
Interventions: DRUG: BCL2 Inhibitor plus IM2 regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing an Intervention to Address Suicide Risk During Substance Use Disorder
Status: COMPLETED
Conditions: Suicide|Substance-Related Disorders
Interventions: BEHAVIORAL: Psychoeducation for substance abuse|BEHAVIORAL: CBT for suicide in Substance abuse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of HQK-1004 and Valganciclovir to Treat Epstein-Barr Virus (EBV) - Positive Lymphoid Malignancies or Lymphoproliferative Disorders
Status: TERMINATED
Conditions: Lymphoid Malignancies|Lymphoproliferative Disorders
Interventions: DRUG: HQK-1004|DRUG: Valganciclovir (may substitute with ganciclovir)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breastfeed a Better Youngster: the BABY Study
Status: COMPLETED
Conditions: Breastfeeding|Breastfeeding, Exclusive|Infant Behavior|Psychological Stress|Breast Milk Expression|Infant Development
Interventions: BEHAVIORAL: Relaxation meditation tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Extracorporal Shockwave Lithotripsy Versus Retrograde Intrarenal Surgery for the Treatment of Kidney Stones
Status: UNKNOWN
Conditions: Kidney Stones
Interventions: PROCEDURE: Extracorporal shockwave lithotripsy|PROCEDURE: Retrograde intrarenal surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of WBV Associated With IMT on Functionality
Status: COMPLETED
Conditions: Frail Elderly Syndrome
Interventions: OTHER: WBV + IMT|OTHER: WBV + IMTsham|OTHER: WBVsham + IMTsham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Interventional Study of Geriatric Frailty, Osteoporosis, and Depression
Status: COMPLETED
Conditions: Frailty|Osteoporosis|Depression
Interventions: BEHAVIORAL: Exercise and nutritional integrated care|BEHAVIORAL: Usual care with education|BEHAVIORAL: Problem solving therapy (PST) integrated care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Life-long Monitoring of Frail Patients With Chronic Diseases
Status: COMPLETED
Conditions: Multiple Chronic Diseases Among Diabetes Mellitus, Chronic Obstructive Pulmonary Diseases and Heart Failure
Interventions: PROCEDURE: Telemonitoring for frail patients with chronic diseases
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: rTMS in Older Adults With MCI and AUD
Status: RECRUITING
Conditions: Alcohol Use Disorder|Mild Cognitive Impairment|Transcranial Magnetic Stimulation
Interventions: DEVICE: Active, Open Label iTBS-rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Way to Be Active V (Framing vs. Forgiveness)
Status: COMPLETED
Conditions: Sedentary Lifestyle
Interventions: BEHAVIORAL: Feedback compared to 75th percentile|BEHAVIORAL: Forgiveness|BEHAVIORAL: Financial Incentive|BEHAVIORAL: Daily Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study to Examine the Safety and Efficacy of Pimavanserin for the Treatment of Agitation and Aggression in Alzheimer's Disease (SERENE)
Status: TERMINATED
Conditions: Agitation and Aggression in Alzheimer's Disease
Interventions: DRUG: Pimavanserin 34 mg|DRUG: Pimavanserin 20 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bridging Thrombolysis Versus Direct Mechanical Thrombectomy in Acute Ischemic Stroke
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DEVICE: Stent-retriever thrombectomy with revascularization device of the Solitaire™ type|DRUG: Intravenous thrombolysis with recombinant tissue-type plasminogen activator (IV t-PA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protopic Ointment in Children Atopic Eczema
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: Tacrolimus 0.03%|DRUG: Fluticasone 0.005%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study of Oral Gabapentin, Oral Alprazolam and Intravenous Dexmedetomidine on Perioperative Anxiety and Pain During Posterior Segment Eye Surgery Under Peribulbar Block : a Randomized, Double-blind Study.
Status: UNKNOWN
Conditions: Sedation for Patients Undergoing Peribulbar Block
Interventions: DRUG: Administration of Alprazolam , Gabapentin , Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Long-term Extension of RECOVER- Long-term Effect of the 24h Transdermal Delivery of Rotigotine in Subjects With Idiopathic Parkinson's Disease
Status: TERMINATED
Conditions: Parkinson's Disease
Interventions: DRUG: Rotigotine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating The Effects Of Bazedoxifene/Conjugated Estrogens On Endometrial Safety And Postmenopausal Osteoporosis
Status: COMPLETED
Conditions: Menopause|Osteoporosis
Interventions: DRUG: bazedoxifene 20 mg/ conjugated estrogens 0.45 mg|DRUG: bazedoxifene 20 mg/ conjugated estrogens 0.625 mg|DRUG: bazedoxifene 20 mg|DRUG: conjugated estrogens 0.45 mg/ medroxyprogesterone acetate 1.5 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Study Generic Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel (Glenmark Generics, Ltd) in the Treatment of Acne Vulgaris.
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel|DRUG: BenzaClin® Topical Gel, Clindamycin 1%/Benzoyl Peroxide 5%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects Of Sitaxsentan On Proteinuria, 24-Hour Blood Pressure, And Arterial Stiffness In Chronic Kidney Disease Subjects
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Open|DRUG: Nifedipine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pomalidomide, Dexamethasone and Pegylated Liposomal Doxorubicin for Relapsed/Refractory Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Pomalidomide|DRUG: Pegylated Liposomal Doxorubicin (PLD)|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glucagon-like Peptide-1 in Type 1 Diabetes
Status: RECRUITING
Conditions: Type1 Diabetes Mellitus
Interventions: DRUG: Glucagon-like peptide-1|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Effect Of Model-Based Dıgıtal Game On Metabolıc Control, Self-Effıcıency And Qualıty Of Lıfe In Chıldren Wıth Type 1 Dıabetes
Status: NOT_YET_RECRUITING
Conditions: Type 1 Diabetes|Pediatric Nursing
Interventions: BEHAVIORAL: Dijital Game and Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Monitoring Endotracheal Tube Cuff Pressure and Keeping it in a Certain Range
Status: COMPLETED
Conditions: Endotracheal Tube|Cuff Pressure|Sore Throat
Interventions: OTHER: keeping the endotracheal tube cuff pressure within a certain range
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Efficacy of Trivalent Live-Attenuated Influenza Vaccine (LAIV) Among Children in Senegal
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: SIIL Live Attenuated Influenza Vaccine|BIOLOGICAL: Matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Impact of Leg Immobilization on Postabsorptive and Postprandial Muscle Protein Breakdown in Healthy Young Males
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Postabsorptive|OTHER: Postprandial|PROCEDURE: Immobilisation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: RCT Comparing OAGB and Long Limb Roux Gastric Bypass
Status: RECRUITING
Conditions: Obesity
Interventions: PROCEDURE: One-anastomosis gastric bypass|PROCEDURE: Long biliary limb Roux gastric bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Caffeine Therapy in the Fetal to Neonatal Transition
Status: RECRUITING
Conditions: Mechanical Ventilation Complication|Caffeine|Ventilator Lung; Newborn
Interventions: DRUG: Early Caffeine administration|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Firehawk Rapamycin Target Eluting Coronary Stent North American Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: Microport Firehawk stent|DEVICE: 2nd generation DES (XIENCE family, Promus family, Resolute/Onyx family/Endeavor, and Orsiro stent)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High(Deadlift) Versus Low Intensity Motor Control Exercises on Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: PROCEDURE: High intensity motor control exercise (deadlift)|PROCEDURE: Low intensity motor control exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rapid Cadence Cycling for Parkinson's Disease: A Study of Implementation and Efficacy in the Community Setting
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: Rapid Cadence Cycling on a Solo-Rider Spin Bicycle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Immunogenicity of LK101 Alone in Participants With Incurable Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: LK101 injection|DRUG: LK101 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of OMS643762 in Psychiatrically Stable Schizophrenia Subjects
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: OMS643762|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study To Investigate If Repeat Doses Of GSK598809 Are Safe And Well Tolerated And To Evaluate Blood Levels Of GSK598809
Status: COMPLETED
Conditions: Substance Dependence
Interventions: DRUG: GSK598809|DRUG: Placebo|DRUG: Caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of XZP-3621 in Chinese Patients With ALK or ROS1 Rearrangement Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: ROS1 Rearrangement Non-small Cell Lung Cancer|ALK Rearrangement Non-small Cell Lung Cancer
Interventions: DRUG: XZP-3621
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phenethyl Isothiocyanate in Preventing Lung Cancer in Smokers
Status: COMPLETED
Conditions: Lung Cancer|Tobacco Use Disorder
Interventions: DRUG: phenethyl isothiocyanate|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Arnica Montana and Bromelain in Rhinoplasty
Status: WITHDRAWN
Conditions: Wound Healing
Interventions: DIETARY_SUPPLEMENT: Arnica Montana|DIETARY_SUPPLEMENT: Bromelain|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: NATURAL HISTORY-Hepatitis C Virus/ Human Immunodeficiency Virus Coinfection
Status: COMPLETED
Conditions: Hepatitis C|HIV|Anemia
Interventions: DRUG: Pegylated Interferon and Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chidamide Plus PTCy/Cyclosporine to Prevent GVHD After Myeloablative Conditioning, Matched PBSCT
Status: UNKNOWN
Conditions: Leukemia, Acute|MDS
Interventions: DRUG: Chidamide|DRUG: Cyclophosphamide|DRUG: cyclosporine A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiometabolic Benefits of Omega-3 Polyunsaturated Fatty Acids
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: Placebo Olive Oil|DIETARY_SUPPLEMENT: High EPA Supplement|DIETARY_SUPPLEMENT: High DHA Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Three Oral Formulations for Hormone Replacement Therapy in Postmenopausal Women
Status: COMPLETED
Conditions: Menopause|Healthy
Interventions: DRUG: 0.5 mg estradiol / 0.1 mg norethisterone acetate (NETA)|DRUG: 0.5 mg estradiol / 0.25 mg norethisterone acetate (NETA)|DRUG: 1.0 mg estradiol / 0.5 mg norethisterone acetate (NETA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Four Surgical Techniques in Primary Total Hip Arthroplasty
Status: UNKNOWN
Conditions: Arthroplasty, Replacement, Hip
Interventions: PROCEDURE: MIS-2 THA|PROCEDURE: MIS-WJ|PROCEDURE: MIS-AL THA|PROCEDURE: MIS-PL THA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Nicotine Uptake and Biomarkers in Adult Smokers Using mybluTM Electronic Cigarettes
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: Myblu flavor A_2.4|OTHER: Myblu flavor B_2.4|OTHER: Myblu flavor C_2.4|OTHER: Myblu flavor D_2.4|OTHER: Myblu flavor E_1.2|OTHER: Myblu flavor F_1.2|OTHER: Myblu flavor G_2.4|OTHER: Myblu flavor H_2.4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Protection Against Emboli During Carotid Artery Stenting Using the Neuroguard IEP System
Status: ACTIVE_NOT_RECRUITING
Conditions: Carotid Artery Stenosis|Carotid Artery Diseases|Carotid Stenosis
Interventions: DEVICE: Carotid artery stenting with Neuroguard IEP System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study of ABI-009 in Nonmuscle Invasive Bladder Cancer
Status: COMPLETED
Conditions: Non-muscle Invasive Bladder Cancer (NMIBC)
Interventions: DRUG: ABI-009|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Azilsartan in Participants With Mild to Moderate Uncomplicated Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Placebo|DRUG: Azilsartan|DRUG: Azilsartan|DRUG: Azilsartan|DRUG: Azilsartan|DRUG: Azilsartan|DRUG: Candesartan cilexetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Staged Treatment in Early Psychosis Study
Status: UNKNOWN
Conditions: Psychotic Disorders|Personality Disorders|Clinical High Risk
Interventions: BEHAVIORAL: Support and Problem Solving Therapy|BEHAVIORAL: Cognitive Behavioural Case Management|DRUG: Fluoxetine|DRUG: Placebo|BEHAVIORAL: 3-monthly monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing the Uncovered to the Covered Wallstent in the Palliation of Malignant Bile Duct Strictures
Status: COMPLETED
Conditions: Inoperable Tumors of the Bile Duct
Interventions: DEVICE: Partially Covered Wallstent|DEVICE: Uncovered Wallstent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of CLA Supplements on Body Weight and Fat Oxidation
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: conjugated linoleic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Response to nCRT for GEJ Cancer Using a Fully Integrated PET/MRI
Status: RECRUITING
Conditions: Esophageal Cancer|Esophageal Neoplasms
Interventions: OTHER: hybrid PET/MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Erlotinib Hydrochloride and Bevacizumab in Treating Patients With Stage IV Breast Cancer
Status: COMPLETED
Conditions: Recurrent Breast Carcinoma|Stage IV Breast Cancer
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Erlotinib Hydrochloride|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of a Triplet Combination of MLN9708, Lenalidomide and Dexamethasone in the Initial Management of Multiple Myeloma (IFM2013-06)
Status: COMPLETED
Conditions: Newly Diagnosed Multiple Myeloma
Interventions: DRUG: MLN9708|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GammaGA: Prevalence of Acid Sphingomyelinase Deficiency Disease (ASMD) and Gaucher Disease in Patients With Monoclonal Gammopathies and/or Multiple Myeloma
Status: RECRUITING
Conditions: Gaucher Disease|Acid SphingoMyelinase Deficiency
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exercise and Parkinson's: Comparing Interventions and Exploring Neural Mechanisms
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: Treadmill|BEHAVIORAL: Tango|BEHAVIORAL: Stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sequential HIPEC of Oxaliplatin and Paclitaxel for Gastric Cancer Patients With Peritoneum Metastasis
Status: UNKNOWN
Conditions: Gastric Cancer|Metastases to Perineum
Interventions: DRUG: Oxaliplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effectiveness and Safety of Two Doses of Risperidone in the Treatment of Children and Adolescents With Autistic Disorder
Status: COMPLETED
Conditions: Autistic Disorder|Autism
Interventions: DRUG: Placebo|DRUG: Risperidone high dose|DRUG: Risperidone low dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Disease Stabilization in AML by Treatment With ATRA, Valproic Acid and Low-dose Cytarabine
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia
Interventions: DRUG: Cytarabine, all-trans retinoic acid, valproic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dialysis Techniques on Blood Pressure and Cardiac Function During Dialysis
Status: COMPLETED
Conditions: End Stage Renal Disease (ESRD)|Hemodialysis|Hemodiafiltration|Intradialytic Hypotension|Diastolic Dysfunction
Interventions: DEVICE: standard hemodialysis|DEVICE: cool hemodialysis|DEVICE: low volume hemodiafiltration|DEVICE: high volume hemodiafiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-label, Long-term Safety Extension Study of AFQ056 in Parkinson's Patients With L-dopa Induced Dyskinesias
Status: COMPLETED
Conditions: Dyskinesias|Parkinson Disease|Movement Disorders|Parkinsonian Disorders|Anti-Dyskinesia Agents
Interventions: DRUG: AFQ056
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction of Cisplatin/Nab-paclitaxel/Pembrolizumab Followed by Olaparib/Pembrolizumab Maintenance in mTNBC Patients
Status: RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Cisplatin|DRUG: Nab-paclitaxel|DRUG: Pembrolizumab|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Cranial Electrical Stimulation (CES) for Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: Active CES|DEVICE: Sham CES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does the Advice to Eat a Mediterranean Diet With Low Carbohydrate Intake, Compared With a Low-fat Diet, Reduce Diabetes and Cardiovascular Disease?
Status: UNKNOWN
Conditions: Ischemic Heart Disease
Interventions: BEHAVIORAL: Advice on what food to choose and eat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Subgluteal Sciatic Nerve Block Versus Caudal Analgesia for Cerebral Palsy Patients Undergoing Lower Limb Corrective Surgeries
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: ultrasound guided Subgluteal sciatic nerve block|PROCEDURE: ultrasound guided Caudal block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of the EatWelLog App on Diet Management for Older Adults With Sarcopenic Obesity
Status: RECRUITING
Conditions: Sarcopenic Obesity
Interventions: BEHAVIORAL: Dietary modification program|BEHAVIORAL: Exercise training|BEHAVIORAL: The EatWellLog App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Clinical Trial Assessing Safety and Efficacy of BZL101 for Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: BZL101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Cohort Assessing the Role of the Genotoxin Colibactin From Escherichia Coli B2 in the Genesis of NASH
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease
Interventions: BIOLOGICAL: liver biopsy|BIOLOGICAL: collection of stools|BIOLOGICAL: blood sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Using Smartphones to Improve Physical Activity Levels of Individuals With Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: BEHAVIORAL: WI program|BEHAVIORAL: WI Program Reminder|BEHAVIORAL: JITAI Goal Setting|BEHAVIORAL: JITAI physical activity message|OTHER: Notification EMA|OTHER: End of day EMA|OTHER: Wake up time EMA|OTHER: Weekly PA Information|OTHER: Daily PA Information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Vaccine Therapy in Treating Patients With Previously Treated Stage II-III HER2-Positive Breast Cancer
Status: COMPLETED
Conditions: HER2-positive Breast Cancer|Male Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: BIOLOGICAL: HER-2/neu peptide vaccine|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Steroid Injections vs. Standard Treatment for Macular Edema Due to Retinal Blood Vessel Blockage
Status: COMPLETED
Conditions: Retinal Vein Occlusion|Macular Edema, Cystoid|Macular Edema
Interventions: DRUG: Triamcinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-blind, Placebo- and Active-controlled Study of the Electric Current Effects of ABT-639 on the Spontaneous Activity of Pain Sensory Receptors in Patients With Diabetic Peripheral Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathic Pain
Interventions: DRUG: ABT-639|DRUG: Placebo|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Virtual Zumba® in Individuals With Developmental Disabilities
Status: COMPLETED
Conditions: Developmental Disability|Autism Spectrum Disorder|Down Syndrome|Cerebral Palsy
Interventions: BEHAVIORAL: Zumba High Tempo|BEHAVIORAL: Zumba Low Tempo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics - Pharmacodynamic Study of HT-2157 in Healthy Subjects and in Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Healthy Volunteers (Part 1)|Major Depressive Disorder (Part 2)
Interventions: DRUG: HT-2157|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Can Peripheral NIRS Predict the Response to a Fluid Challenge in Pediatric Patients: An Interventional Study
Status: RECRUITING
Conditions: Anesthesia
Interventions: DIAGNOSTIC_TEST: Fluid challenge (cristalloïd, NaCl 0,9%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Vancomycin and Negative Pressure Therapy for Post-sternotomy Deep Sternal Wound Infection
Status: COMPLETED
Conditions: Post-Sternotomy Deep Sternal Wound Infection
Interventions: DRUG: Intravenous Vancomycin administration|OTHER: Standard postoperative therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Impact of Prehabilitation Bundle on Perioperative Outcome for Frail Elderly Patients Undergoing Major Abdominal Surgery
Status: UNKNOWN
Conditions: Complication, Postoperative|Perioperative/Postoperative Complications
Interventions: DIETARY_SUPPLEMENT: Ensure, Resource 2.0 and Glucerna|OTHER: Cognitive Training, Memory Card Game|DEVICE: 'Threshold' Inspiratory Muscle Trainer, Respironics of New Jersey Inc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Vitreous Composition Determined by Ultrasound and Optical Coherence Tomography (OCT) on Ranibizumab Therapy
Status: COMPLETED
Conditions: Choroidal Neovascularization
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intravenous Infusion for TBI
Status: NOT_YET_RECRUITING
Conditions: Traumatic Brain Injury
Interventions: BIOLOGICAL: AlloRx
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Intake of Tryptophan and Metformin Response
Status: COMPLETED
Conditions: Metformin Response|Fasting Glucose|Tryptophan Concentration|Metformin Concentration|Diet Tolerability
Interventions: DRUG: Metformin|OTHER: Low tryptophan diet|OTHER: High tryptophan diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploration of Gemfibrozil as a Treatment for AUD
Status: TERMINATED
Conditions: Alcohol Use Disorder
Interventions: DRUG: Gemfibrozil 600 MG|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Exercise for Wound Healing in the Larynx
Status: COMPLETED
Conditions: Acute Phonotrauma
Interventions: BEHAVIORAL: Resonant voice|BEHAVIORAL: Voice rest|BEHAVIORAL: Spontaneous speech
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of FG-3019 in Subjects With Liver Fibrosis Due to Chronic Hepatitis B Infection
Status: TERMINATED
Conditions: Liver Fibrosis Due to Chronic Hepatitis B Infection
Interventions: DRUG: FG-3019|DRUG: Placebo|DRUG: Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Post-Procedural Biotech Cellulose Mask
Status: COMPLETED
Conditions: Temperature Change, Body
Interventions: OTHER: Velez Intense Hydration Mask® (biotech cellulose face mask)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT