pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pharmacokinetic Study of Buparlisib in Subjects With Renal Impairment.
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Buparlisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate the Effect of Food Intake on the Plasma Concentration Changes of Quetiapine After Oral Administration of FK949E in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy|Plasma Concentration Change of Quetiapine
Interventions: DRUG: FK949E
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Creatine Supplementation in Addition to Resistance Exercise Training in Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Lower Extremity Resistance Exercise Training|OTHER: Home Exercise Plan|DEVICE: Electrotherapy + Heating|PROCEDURE: Joint Mobilization|DIETARY_SUPPLEMENT: Creatine Supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Effects and of Modifications in Apoptosis Regulators Observed After Stopping 5-ASA Treatment in Patients With Inactive Ulcerative Colitis
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: BEHAVIORAL: Observe patients with inactive ulcerative colitis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Clinical Activity of GSK2857916
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: GSK2857916
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changing the Natural History of Type 2 Diabetes ("CHANGE" Study)
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: OTHER: Intensification of diabetes medication based largely on HbA1c levels|OTHER: Intensification of diabetes medication based on glucose levels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Traditional and MOSES Laser Enucleation of the Prostate (MOLEP): A Prospective, Randomized, Double-blinded Control Trial A Comparison of Traditional and MOSES Laser Enucleation of the Prostate (MOLEP): A Prospective, Randomized, Double-blinded Control Trial
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: PROCEDURE: Moses laser enucleation of prostate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Dehydroepiandrosterone (DHEA) in Respiratory Pulmonary Hypertension in Adults
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease|Hypertension, Pulmonary
Interventions: DRUG: DHEA treatment|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Glucose Monitoring in HIE
Status: RECRUITING
Conditions: Hypoxic Ischemic Encephalopathy of Newborn|Hyperglycemia|Hypoglycemia
Interventions: DEVICE: Dexcom ONE+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Direct Oral Anticoagulants and Venous Thromboembolism
Status: COMPLETED
Conditions: Venous Thromboembolism|Major Bleed
Interventions: DRUG: Apixaban (ATC B01AF02)|DRUG: Dabigatran (ATC B01AE07)|DRUG: Rivaroxaban (ATC B01AF01)|DRUG: Warfarin (ATC B01AA03)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Spinal Manipulation Effectiveness in Spinal Disorders
Status: UNKNOWN
Conditions: Low Back Pain|Cervical Pain|Pain
Interventions: OTHER: Spinal Manipulation|OTHER: Sham manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bintrafusp Alfa With Chemotherapy for Tyrosine Kinase Inhibitor-Resistant EGFR-Mutant Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Locally Advanced Lung Non-Squamous Non-Small Cell Carcinoma|Metastatic Lung Non-Squamous Non-Small Cell Carcinoma|Stage III Lung Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8|Stage IIIB Lung Cancer AJCC v8|Stage IIIC Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8|Unresectable Lung Non-Squamous Non-Small Cell Carcinoma
Interventions: DRUG: Bintrafusp Alfa|DRUG: Pemetrexed|DRUG: Carboplatin|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rotigotine Patch in Subjects With Advanced Stage, Idiopathic Parkinson's Disease Who Are Not Well Controlled on Levodopa
Status: COMPLETED
Conditions: Parkinson Disease, Idiopathic
Interventions: DRUG: SPM 962
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: HIV-Related Stigma Intervention for Malaysian Clinicians
Status: COMPLETED
Conditions: Hiv
Interventions: BEHAVIORAL: HIV Connect|BEHAVIORAL: Project ECHO for HIV Prevention|BEHAVIORAL: Project ECHO for HIV Prevention and Stigma Reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: Management of Peri-implant Mucositis With Ozone Water Jet: a Randomized Clinical Trial.
Status: COMPLETED
Conditions: Peri-implant Mucositis
Interventions: OTHER: Ozonized water|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sorafenib Dose Ramp-Up in Hepatocellular Carcinoma (HCC)
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Sorafenib Standard Dosing Regimen|DRUG: Sorafenib Ramp-Up Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Vitamin D Insufficiency and Deficiency Associated With Antepartum and Postpartum Depression?
Status: TERMINATED
Conditions: Depression|Postpartum Depression
Interventions: DIETARY_SUPPLEMENT: Vitamin D3 (Cholecalciferol)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nonarthritic Hip Disease Evaluation And Treatment
Status: TERMINATED
Conditions: Clinical Decision Making|Nonarthritic Hip Disease
Interventions: OTHER: Interdisciplinary Evaluation for Nonarthritic Hip Disease|OTHER: Posture and Movement Training|OTHER: Treatment-of-choice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Carfilzomib|DRUG: Thalidomide|DRUG: Dexamethasone|DRUG: Daratumumab|DRUG: Cisplatin|DRUG: Adriamycin|DRUG: Cyclophosphamide|DRUG: Etoposide|DRUG: Melphalan|PROCEDURE: ASCT|DRUG: Lenalidomide|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positive Cueing in Knee Arthroplasty.
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Psychological Stress|Mental Stress
Interventions: BEHAVIORAL: Positive cueing in the information video before a primary TKA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pan-genotypic Direct Acting Antiviral Therapy in Donor HCV-positive to Recipient HCV-negative Lung Transplant
Status: TERMINATED
Conditions: Respiratory Failure|Hepatitis C
Interventions: DRUG: Clinically prescribed direct acting antiviral (Mavyret or Epclusa) HCV treatment for 8 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamics of JNJ-64179375 in Healthy Japanese Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-64179375 0.3 mg/kg|DRUG: JNJ-64179375 1.0 mg/kg|DRUG: JNJ-64179375 2.5 mg/kg|OTHER: Placebo|DRUG: JNJ-64179375 (Dose to be Determined)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis
Status: COMPLETED
Conditions: Henoch-Schönlein Purpura Nephritis
Interventions: DRUG: tacrolimus|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SGLT2 Inhibitors as a Novel Treatment for Pediatric Non-Alcoholic Fatty Liver Disease
Status: NOT_YET_RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease|NAFLD|Pediatric NAFLD
Interventions: DRUG: Empagliflozin 10 MG|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Outcomes Between Foot Cast and Short Leg Cast in the Patients With Acute Closed Fracture of Proximal Fifth Metatarsal (Zone II)
Status: COMPLETED
Conditions: Acute Closed Fracture of Proximal Fifth Metatarsal (Zone II)
Interventions: DEVICE: short foot cast|DEVICE: short leg cast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Uncertainty Analysis of Computational Model to Simulate Neurostimulation Caused by Gradient Fields in MRI
Status: COMPLETED
Conditions: Peripheral Nerve Stimulation in MRI|Electric Stimulation
Interventions: OTHER: Peripheral nerve stimulation provocation study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Ultrasound-Guided Perimeniscal Steroid and 5% Dextrose Injections in Knee Osteoarthritis
Status: COMPLETED
Conditions: Gonarthrosis|Meniscus; Degeneration|Pain, Chronic
Interventions: DRUG: Triamcinolone Hexacetonide|DRUG: Dextrose 5% in water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Different Concentrations of Mapracorat Ointment Over 4 Weeks in Atopic Dermatitis (AD)
Status: COMPLETED
Conditions: Atopic Dermatitis|Eczema
Interventions: DRUG: Mapracorat|DRUG: Vehicle without active
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Value of Biological Age, in Addition to Individual Frailty, for Personalising the Management of Cancer Treated With Targeted Therapy
Status: RECRUITING
Conditions: Leukemia,Myeloid, Chronic
Interventions: BIOLOGICAL: Blood and bone marrow sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Multi-Ethnic Study of Atherosclerosis (MESA)
Status: ACTIVE_NOT_RECRUITING
Conditions: Atherosclerosis|Cardiovascular Diseases|Heart Diseases|Coronary Artery Disease|Coronary Disease|Stroke|Myocardial Infarction|Heart Failure|Diabetes Mellitus, Type 2|Hypertension|Diabetes Mellitus
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetic and Safety Study of LY03004 in Stable Patients With Schizophrenia or Schizoaffective Disorder
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: LY03004
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study Using the Xoft System for the Treatment of Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Cancer
Interventions: RADIATION: brachytherapy|RADIATION: Xoft Axxent Electronic Brachytherapy System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-Operative Nodal Staging of Thyroid Cancer Using USPIO MRI: Preliminary Study
Status: COMPLETED
Conditions: Papillary Carcinoma of Thyroid Gland|Metastatic Medullary Thyroid Cancer|Follicular Thyroid Cancer Lymph Node Metastasis
Interventions: DRUG: Ferumoxytol|DEVICE: Nanoparticle MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Clinical Study Assessing Critical Errors, Training/Teaching Time, and Preference Attributes of the ELLIPTA® Dry Powder Inhaler, in Comparison to Combinations of Dry Powder Inhalers Used to Provide Triple Therapy, in Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DEVICE: Placebo ELLIPTA|DEVICE: Placebo DISKUS|DEVICE: Placebo TURBUHALER|DEVICE: Placebo HANDIHALER|OTHER: PQ1|OTHER: PQ2|OTHER: PQ3|OTHER: PQ4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Effect on Gastroduodenal Mucosa of PA32540, PA32540 and Celecoxib, and Aspirin With Celecoxib
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PA32540|DRUG: PA32540 and celecoxib|DRUG: aspirin and [NSAID]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Open Study of BAY77-1931 (Lanthanum Carbonate) in Continuous Ambulatory Peritoneal Dialysis Patients
Status: COMPLETED
Conditions: Hyperphosphatemia
Interventions: DRUG: Lanthanum Carbonate (BAY77-1931)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MCT for the Harvard/UCSF ROBIN Center
Status: RECRUITING
Conditions: Glioma, Childhood Brainstem|Neuroblastoma
Interventions: RADIATION: External beam radiotherapy|RADIATION: 131I-Metaiodobenzylguanidine (MIBG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neurosciences-Intensive Care Unit Electrical Stimulation
Status: COMPLETED
Conditions: Intensive Care (ICU) Myopathy
Interventions: DEVICE: Electrical Stimulation Treatment|DEVICE: Neuromuscular Electrical Stimulation Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Growth, Risks of Allergy and Metabolic Syndrome in 6 Year Old Children Born Preterm Compared to Postdischarge Nutrition
Status: COMPLETED
Conditions: Infant, Very Low Birth Weight|Metabolic Syndrome, Protection Against|Allergy|Dietary Modification
Interventions: DIETARY_SUPPLEMENT: Enfamil HM fortifier, Mead Johnson|DIETARY_SUPPLEMENT: Enfalac Premature Formula, Mead Johnson Nutritionals|DIETARY_SUPPLEMENT: Mothers own milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propionic Acid in Multiple Sclerosis
Status: ENROLLING_BY_INVITATION
Conditions: Multiple Sclerosis
Interventions: DIETARY_SUPPLEMENT: Propionic acid 1000 mg capsule|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MR Guided Focused Ultrasound vs Radiotherapy for Palliative Pain Tx in Bone Metastases
Status: NOT_YET_RECRUITING
Conditions: Bone Metastases
Interventions: PROCEDURE: MR- High intensity focused ultrasound|RADIATION: External beam radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: R2-CHOP in Untreated DEL-DLBCL：An Open-lable，Multicenter，Phase II Study
Status: UNKNOWN
Conditions: DLBCL
Interventions: DRUG: R2-CHOP(Lenalidomide,Rituximab,cyclophosphamide，hydroxyldaunorubicin，Vincristine，Prednisone）)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of CRS3123 vs. Oral Vancomycin in Adult Patients With Clostridioides Difficile Infection
Status: ACTIVE_NOT_RECRUITING
Conditions: Clostridioides Difficile Infection
Interventions: DRUG: CRS3123|DRUG: Active Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial of KB001 in Mechanically-Ventilated Patients Colonized With Pseudomonas Aeruginosa
Status: COMPLETED
Conditions: Pseudomonas Aeruginosa|Ventilator Associated Pneumonia
Interventions: BIOLOGICAL: KB001|BIOLOGICAL: KB001|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Efficacy and Safety of Indigo Naturalis Oil Extract on Psoriatic Nails
Status: COMPLETED
Conditions: Nail Psoriasis
Interventions: DRUG: Indigo Naturalis Extract in Oil|OTHER: Olive Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of ADW S-100 Ionized Water Nasal Spray in Decreasing SARS-Cov-2 Viral Load.
Status: TERMINATED
Conditions: SARS-CoV-2 Infection
Interventions: DEVICE: nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Lung Bioavailability and Total Systemic Exposure to Beclomethasone17MonoPropionate and Formoterol Across Two Strengths of NEXThaler Inhalation Powder
Status: COMPLETED
Conditions: Asthmatic
Interventions: DRUG: NEXThaler 100/6 mcg DPI|DRUG: Flixotide Accuhaler 500 mcg|DRUG: NEXThaler 200/6 mcg DPI|DRUG: NEXThaler placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of WT1 or NY-ESO-1 Vaccine and Nivolumab For Recurrent Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Fallopian Tube|Primary Peritoneal Cancer|Recurrent Ovarian Cancer
Interventions: BIOLOGICAL: WT1 Vaccine|DRUG: Nivolumab|BIOLOGICAL: NY-ESO-1 Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Avatrombopag in Thrombocytopenic Patients With Chronic Liver Disease Undergoing an Elective Procedure
Status: RECRUITING
Conditions: Thrombocytopenia; Drugs|Chronic Liver Disease
Interventions: DRUG: Avatrombopag maleate|BIOLOGICAL: Platelet transfusion|DRUG: Medicine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine With Ascorbate Including Adolescents
Status: WITHDRAWN
Conditions: Soft Tissue Sarcoma|Bone Sarcoma|Unresectable Soft Tissue Sarcoma|Metastatic Bone Sarcoma|Metastatic Soft-tissue Sarcoma|Unresectable Bone Sarcoma
Interventions: DRUG: Ascorbate|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Ropivacaine Alone Versus Combination of Dexamethasone and Clonidine for Block
Status: COMPLETED
Conditions: Upper Extremity Surgery
Interventions: DRUG: Ropivacaine|DRUG: Ropivacaine and dexamethasone|DRUG: Ropivacaine and clonidine|DRUG: Ropivacaine, dexamethasone and clonidine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Renal Cell Arrest and Damage Biomarkers in Progression and Outcome of Septic AKI
Status: COMPLETED
Conditions: AKI - Acute Kidney Injury
Interventions: DIAGNOSTIC_TEST: renal cell arrest and damage biomarkers assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Response to Pegylated Interferon and Ribavirin in Chinese Patients With Chronic Hepatitis C Genotypes 1 Versus 2/3 Versus 6
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: 48-weeks course|DRUG: Ribavirin|DRUG: Peginterferon alfa2a|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Intervention for Inflammatory Bowel Disease Remission
Status: NOT_YET_RECRUITING
Conditions: Inflammatory Bowel Diseases
Interventions: OTHER: Mediterranean diet and Anti-inflammatory diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study on the Evaluation of Irreversible Electroporation Technique in Infiltrating Perihilar Cholangiocarcinoma
Status: WITHDRAWN
Conditions: Cholangiocarcinoma|Interventional Imaging
Interventions: PROCEDURE: Irreversible electroporation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiolabeled Monoclonal Antibody Therapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Metastatic or Recurrent Colorectal Cancer or Pancreatic Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Pancreatic Cancer
Interventions: BIOLOGICAL: filgrastim|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: indium In 111 monoclonal antibody MN-14|RADIATION: yttrium Y 90 monoclonal antibody MN-14
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Effects of Vatalanib in Combination With Capecitabine in Patients With Advanced Cancer
Status: COMPLETED
Conditions: Tumors|Neoplasm Metastasis
Interventions: DRUG: PTK787/ZK 222584 (vatalanib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Obatoclax and Bortezomib in Treating Patients With Aggressive Relapsed or Recurrent Non-Hodgkin Lymphoma
Status: TERMINATED
Conditions: Adult Non-Hodgkin Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma
Interventions: DRUG: obatoclax mesylate|DRUG: bortezomib|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Evaluation of Telmisartan Plus Hydrochlorothiazide in Patients With Mild-to-Moderate Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan/hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Juice Plus+® Supplementation on Endothelial Function in Overweight Men
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: Juice Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Safety, Tolerability and Effect on Glycemic Control of Taspoglutide Versus Insulin Glargine in Insulin Naive Type 2 Diabetic Patients Inadequately Controlled With Metformin Plus Sulphonylurea.
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: insulin glargine|DRUG: metformin|DRUG: taspoglutide|DRUG: taspoglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study Evaluating CTX001 in Subjects With Severe Sickle Cell Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Sickle Cell Disease|Hematological Diseases|Hemoglobinopathies
Interventions: BIOLOGICAL: CTX001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0410 Tandem Stem Cell Transplantation in Treating Patients With Progressive or Recurrent Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: carmustine|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: melphalan|PROCEDURE: autologous-autologous tandem hematopoietic stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Oral Recombinant Salmon Calcitonin (rsCT) to Prevent Postmenopausal Osteoporosis
Status: COMPLETED
Conditions: Osteopenia
Interventions: DRUG: Oral calcitonin at dinnertime|DRUG: Oral placebo at dinnertime|DRUG: Oral calcitonin at bedtime|DRUG: Oral placebo at bedtime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: VitamIn and oXygen Interventions and Cardiovascular Events
Status: COMPLETED
Conditions: Postoperative Cardiac Complication
Interventions: DRUG: Oxygen|DRUG: Antioxidants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy
Status: RECRUITING
Conditions: Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Myelodysplastic Syndrome|Recurrent Juvenile Myelomonocytic Leukemia|Refractory Childhood Acute Myeloid Leukemia|Refractory Childhood Myelodysplastic Syndrome|Refractory Juvenile Myelomonocytic Leukemia
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|DRUG: Cytarabine|PROCEDURE: Echocardiography|DRUG: Fludarabine|DRUG: Hydrocortisone Sodium Succinate|BIOLOGICAL: Imetelstat|DRUG: Leucovorin Calcium|PROCEDURE: Lumbar Puncture|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Salmeterol Via HandiHaler® in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Salmeterol capsule - low|DRUG: Salmeterol capsule - high|DRUG: Salmeterol via Serevent® Diskus®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Action Observation Therapy on Fine Motor Skills of Upper Limb Functions in Chronic Stroke Patients.
Status: COMPLETED
Conditions: Chronic Stroke
Interventions: OTHER: Neurodevelopmental Techniques|OTHER: Action observation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Vardenafil on Blood Pressure in Patients With Erectile Dysfunction Who Received Concomitant Doxazosin GITS
Status: COMPLETED
Conditions: Prostatic Hyperplasia|Impotence
Interventions: DRUG: Vardenafil 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Investigate the Exposure to Selected Smoke Constituents in Smokers Switching to Distillation Based Smoking Article
Status: COMPLETED
Conditions: Smoking
Interventions: OTHER: Distillation based smoking article (SMAR cigarette)|OTHER: conventional cigarette|OTHER: smoking cessation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Leverage Noninvasive Transcutaneous Vagus Nerve Stimulation to Reduce Suicidal Behaviors in Vulnerable Adolescents
Status: RECRUITING
Conditions: Self Harm|Suicidal Ideation
Interventions: DEVICE: tVns Program|OTHER: Phone App Program|COMBINATION_PRODUCT: tVNS and Phone App Program|OTHER: Enhanced Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Genistein in Treating Patients With Prostate Cancer
Status: TERMINATED
Conditions: Adenocarcinoma of the Prostate|Recurrent Prostate Cancer|Stage I Prostate Cancer|Stage II Prostate Cancer|Stage III Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: genistein|OTHER: placebo|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of BUFY01 Versus SVS20 in the Treatment of Dry Eye Disease
Status: NOT_YET_RECRUITING
Conditions: Dry Eye Disease
Interventions: DEVICE: BUFY01 eye drops in single-dose containers|DEVICE: SVS20 eye drops in single-dose containers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Caudal Dexmedetomidine Analgesia in Pediatrics .
Status: COMPLETED
Conditions: 164 Boys for Hypospadias Surgery Under General Anesthesia With Caudal Block
Interventions: DRUG: Caudal dexamedatomidine analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of PEG-rhG-CSF and rhG-CSF Used for Aplastic Anemia Granulocyte Deficiency
Status: RECRUITING
Conditions: Severe Aplastic Anemia
Interventions: DRUG: PEG-rhG-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of EQ001 (Itolizumab) in Systemic Lupus Erythematosus With or Without Active Proliferative Nephritis
Status: COMPLETED
Conditions: Lupus Erythematosus|Lupus Nephritis
Interventions: DRUG: Itolizumab [Bmab 600]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Progesterone on LH Pulses During the Follicular Phase (CRM006)
Status: TERMINATED
Conditions: Female Reproductive Physiology
Interventions: DRUG: oral micronized progesterone suspension|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety & Efficacy of Subretinal Implants for Partial Restoration of Vision in Blind Patients
Status: COMPLETED
Conditions: Retinal Degeneration|Retinitis Pigmentosa
Interventions: PROCEDURE: surgical implantation of subretinal device|PROCEDURE: surgical implantation of subretinal device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stromal Cells for Infants With Congenital Heart Disease (MedCaP)
Status: ACTIVE_NOT_RECRUITING
Conditions: Congenital Heart Disease (CHD)
Interventions: BIOLOGICAL: BM-MSC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study in Adult Subjects With Acute Migraines
Status: COMPLETED
Conditions: Migraine, With or Without Aura
Interventions: DRUG: Rimegepant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolism and Pharmacokinetics of Primaquine Enantiomers in Human Volunteers, Study 1
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Primaquine, R-Primaquine, S-Primaquine, SR Primaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Multiple Ascending Dose Study of BPN14770 in Healthy Young and Elderly Male or Female Subjects
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: BPN14770|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Using of Virtual Reality to Relieve Procedural Pain in Pediatric Oncology.
Status: RECRUITING
Conditions: Hematologic Malignancy|Hematologic Non Malignancy|Solid Tumor, Childhood|Child, Only
Interventions: OTHER: Usual distraction and pain prevention techniques.|OTHER: Virtual reality|OTHER: Choice between usual distraction or virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CCRC: Effects of Partially Hydrolyzed Whey Peptides (PHWP) On Weight Loss In Individuals With The Metabolic Syndrome (METS)
Status: COMPLETED
Conditions: Metabolic Syndrome|Overweight
Interventions: DIETARY_SUPPLEMENT: Weight Loss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sifrol (Pramipexole) Onset of Action and Impact: a 12-weeks Observational Study in Patients With Primary Restless Legs Syndrome
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DRUG: Sifrol® (pramipexole dihydrochloride)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Longitudinal Assessment of Genomic Alterations and Clonal Evolution in ALK-positive NSCLC (Galileo Project)
Status: RECRUITING
Conditions: ALK Gene Mutation|NSCLC Stage IV|ALK Sensitizing Mutation
Interventions: DIAGNOSTIC_TEST: Biopsy (tissue or liquid)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Topical Adrenaline Versus Warm Saline Solution for Minimizing Intraperitoneal Bleeding During Caesarian Delivery for Placenta Previa / Accreta Spectrum ( PAS)
Status: RECRUITING
Conditions: Placenta Accreta|Placenta Previa
Interventions: DRUG: Topical adrenaline|DRUG: Warm saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hula, a Physical Activity Intervention for Female-Cancer Survivors
Status: COMPLETED
Conditions: Physical Activity|Breast Cancer|Cervical Cancer|Ovarian Cancer|Endometrial Cancer
Interventions: BEHAVIORAL: Hula
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combined Treatment of Minocycline and Lovastatin to Treat Individuals With Fragile X Syndrome
Status: COMPLETED
Conditions: Fragile X Syndrome
Interventions: DRUG: Minocycline, then Minocycline/Lovastatin|DRUG: Lovastatin, then Minocycline/Lovastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of the Bioavailability of Short Chain Fatty Acids in Healthy Humans
Status: COMPLETED
Conditions: Short Chain Fatty Acids Bioavailability
Interventions: DIETARY_SUPPLEMENT: 13C-labeled Acetate|DIETARY_SUPPLEMENT: 13C-labeled propionate|DIETARY_SUPPLEMENT: 13C-labeled butyrate|DIETARY_SUPPLEMENT: Inulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Co-treatment With Pegvisomant and a Somatostatin Analogue (SA) in SA-responsive Acromegalic Patients
Status: COMPLETED
Conditions: Acromegaly|Insulin Resistance|Impaired Glucose Tolerance
Interventions: DRUG: Pegvisomant|DRUG: Somatostatin analog (lanreotide or octreotide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Radiotherapy for Stage I-III Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer|Prostatic Cancer|Prostate Neoplasms|Prostatic Neoplasms|Cancer of the Prostate
Interventions: RADIATION: CyberKnife Stereotactic Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Doxorubicin Hydrochloride and Alvocidib in Treating Patients With Metastatic or Recurrent Sarcoma That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumor|Recurrent Adult Soft Tissue Sarcoma|Stage IV Adult Soft Tissue Sarcoma
Interventions: DRUG: alvocidib|DRUG: doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Topical Tranexamic Acid on Pre- and Post-operative Hemoglobin/Hematocrit
Status: RECRUITING
Conditions: Fracture of Posterior Wall of Acetabulum
Interventions: DRUG: Tranexamic Acid|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Clinical Study of Pyrotinib Combined With Etoposide to Treat HER2-positive Advanced Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Pyrotinib|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Treprostinil Palmitil Inhalation Powder (TPIP) in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Treprostinil Palmitil Inhalation Powder|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of a Semi-automated Closed Vitrification System (Gavi®) With a Manual Open Vitrification Sytem (Cryotop®)
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: Gavi® Vitrification|PROCEDURE: Cryotop® Vitrification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effects of 4 Week β-alanine Supplementation on Knee Extensor Contractile and Force Properties in the Over 60s
Status: SUSPENDED
Conditions: Muscle Function
Interventions: DIETARY_SUPPLEMENT: beta-alanine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hormone Replacement Therapy for Use in Postmenopausal Women for Relief of Hot Flushes and Urogenital Symptoms.
Status: COMPLETED
Conditions: Hormone Replacement Therapy
Interventions: DRUG: Estradiol acetate|DRUG: Estradiol|DRUG: Conjugated equine estrogens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Preimplantation Genetic Diagnosis in Autosomal Dominant Polycystic Kidney Disease Patients: a Multicenter Clinical Trial
Status: COMPLETED
Conditions: Polycystic Kidney, Type 1 Autosomal Dominant Disease
Interventions: PROCEDURE: Preimplantation Genetic Diagnosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sarcosinamide Nitrosourea in Treating Patients With Metastatic or Unresectable Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: SarCNU|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of RM-1929 and Photoimmunotherapy in Patients With Recurrent Head and Neck Cancer
Status: COMPLETED
Conditions: Recurrent Head and Neck Cancer
Interventions: COMBINATION_PRODUCT: PIT: 50 J/cm^2 for superficial lesions or 100 J/cm for interstitial lesions and Drug RM-1929: 160 mg/m^2|COMBINATION_PRODUCT: PIT: 50 J/cm^2 for superficial lesions or 100 J/cm for interstitial lesions and Drug RM-1929: 320 mg/m^2|COMBINATION_PRODUCT: PIT: 50 J/cm^2 for superficial lesions or 100 J/cm for interstitial lesions and Drug RM-1929: 640 mg/m^2|COMBINATION_PRODUCT: PIT: 75 J/cm^2 for superficial lesions or 150 J/cm for interstitial lesions and Drug RM-1929: 640mg/m^2|COMBINATION_PRODUCT: PIT: 100 J/cm^2 for superficial lesions or 200 J/cm for interstitial lesions and Drug RM-1929: 640mg/m^2|COMBINATION_PRODUCT: PIT: 50 J/cm^2 for superficial lesions or 100 J/cm for interstitial lesions and Drug RM-1929: 640mg/m^2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Hybrid Effectiveness-implementation Trial of a High School-based Executive Function Treatment for Autistic Youth
Status: ENROLLING_BY_INVITATION
Conditions: Executive Dysfunction|Autism Spectrum Disorder|Adolescent Behavior
Interventions: BEHAVIORAL: Unstuck & On Target: High School|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vacuum Myofascial Therapy Device and Physical Activity for the Treatment of Chronic Non-specific Low Back Pain. A Single Blind Randomized Clinical Trial
Status: COMPLETED
Conditions: Chronic Nonspecific Low Back Pain
Interventions: PROCEDURE: Vacuum myofascial therapy and physical activity program.|OTHER: Physical activity program.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Tempromandibular Joint Anterior Disc Displacement With Different Materials
Status: RECRUITING
Conditions: TMJ Disc Disorder
Interventions: PROCEDURE: intra-articular injection with Platelet lysate (PL).|PROCEDURE: intra-articular injection with Hyaluronic Acid.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sequential Letrozole and Methotrexate Therapy Role in Treatment of Tubal Ectopic Pregnancy
Status: COMPLETED
Conditions: Pregnancy Tubal
Interventions: DRUG: Methotrexate|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Immunotherapy Combined With Chemotherapy and Anti-angiogenic Therapy in Operable NSCLC
Status: ENROLLING_BY_INVITATION
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: envafolimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindfulness in Post Acute Sequelae of SARS-CoV-2 Infection (PASC) Dysautonomia
Status: COMPLETED
Conditions: Long COVID|Dysautonomia
Interventions: OTHER: Mindfulness - Mindful Awareness Practices ( MAPs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Early Aggressive Invasive Intervention for Atrial Fibrillation
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Cryoballoon-based PVI|DRUG: Anti-Arrhythmic Drug Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SpO2 Accuracy Comparison of Medline ReNewal Sensors to Arterial Blood CO-Oximetry
Status: COMPLETED
Conditions: Arterial Oxygen Saturation|Healthy
Interventions: DEVICE: MEDLINE RENEWAL PULSE OXIMETRY SENSORS|DEVICE: CO-OXIMETRY SENSORS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Intermittent Oro-esophageal Tube Feeding in Late Dysphagia for Nasopharyngeal Carcinoma
Status: WITHDRAWN
Conditions: Dysphagia
Interventions: DEVICE: Intermittent Oral-esophageal Tube Feeding|DEVICE: Nasogastric Tube Feeding|BEHAVIORAL: comprehensive rehabilitation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combined Cytidine and Creatine-containing Drug in the Treatment of the Bipolar Depression
Status: WITHDRAWN
Conditions: Depression, Bipolar
Interventions: DRUG: Valproate and Placebo|DRUG: Valproate and Cytidine-containing Drug|DRUG: Valproate and Creatine-containing Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT