pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Efficacy of 6% Hydroxyethyl Starch (HES) Solution Versus an Electrolyte Solution in Patients Undergoing Elective Abdominal Surgery
Status: COMPLETED
Conditions: Hypovolaemia Due to Acute Blood Loss
Interventions: DRUG: Volulyte 6%|DRUG: Ionolyte
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Myocardial Infarction and Unstable Angina Patients With PCSK9 Inhibitor Usage Study
Status: UNKNOWN
Conditions: Lipid Metabolism|Cardiovascular Diseases
Interventions: DRUG: PCSK9 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Safety and Immunogenicity of a Trivalent Group B Streptococcus Vaccine in Healthy Pregnant Women
Status: COMPLETED
Conditions: GBS Disease|Streptococcus Agalactiae
Interventions: BIOLOGICAL: GBS trivalent vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oral Probiotics on the Microbiome and Lipidome in Acne Vulgaris
Status: UNKNOWN
Conditions: Acne Vulgaris
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Ciclesonide MDI 50mg/Day and 200mg/Day (Ex-Valve) Once-Daily on Growth in Children With Mild Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: ciclesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Hyperpolarized 13C Pyruvate as a Biomarker in Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: Hyperpolarized 13C-Pyruvate|PROCEDURE: Magnetic Resonance Imaging (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of Intrahepatic Arterial Injection of 90-Y Glass Microspheres for Cholangiocarcinoma
Status: COMPLETED
Conditions: Cholangiocarcinoma
Interventions: DEVICE: TheraSphere® Yttrium-90 (Y-90) Microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preliminary Efficacy Analysis of Cheng's Giraffe Reconstruction After Proximal Gastrectomy
Status: UNKNOWN
Conditions: Gastric Cancer|Reflux Esophagitis
Interventions: PROCEDURE: proximal gastrectomy combined with Cheng's Giraffe reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KN046 in Patients With Advanced Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Stage IV Non-small Cell Lung Cancer
Interventions: DRUG: KN046|DRUG: KN046|DRUG: KN046|DRUG: Carboplatin|DRUG: Pemetrexed|DRUG: Ningetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closing Volume Interpretation and Bronchodilators Effect
Status: COMPLETED
Conditions: Healthy|COPD
Interventions: DRUG: Indacaterol maleate|DRUG: Tiotropium bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia
Status: RECRUITING
Conditions: Hypotension
Interventions: DRUG: Noradrenalin|DRUG: Phenylephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Complex Regional Pain Syndrome (CRPS) is a Chronic Pain Condition. This is a Preliminary Study to Explore and Test Clinical Hypothesis. They Suppose That CRPS Patients Have Impairment in Their Mental or Motor Imagery Abilities.
Status: COMPLETED
Conditions: Complex Regional Pain Syndromes|Musculoskeletal Pain Disorder|Healthy
Interventions: DIAGNOSTIC_TEST: Motor imagery Questionnaire - Revised Second (MIQ-RS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Assessing the Synergistic Effects of Black Cohosh, Soy Isoflavones, and SDG Lignans (Soloways TM) on Menopausal Symptoms
Status: COMPLETED
Conditions: Menopause Symptoms
Interventions: DIETARY_SUPPLEMENT: supplementation|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ustekinumab for the Treatment of Relapse of Refractory Giant Cell Arteritis
Status: RECRUITING
Conditions: Patients Relapsing Refractory Giant Cell Arteritis
Interventions: DRUG: prednisone treatment|DRUG: prednisone and ustekinumab treatment|OTHER: questionnaires|BIOLOGICAL: Blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Utility of the 1-minute Sit to Stand Test as a Measure of Submaximal Exercise Tolerance in Patients With Cystic Fibrosis During Acute Pulmonary Exacerbation
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DIAGNOSTIC_TEST: Sit to stand test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Role of Minerelocorticoid Receptor on Modulating Aldosterone Production
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Placebo|DRUG: Fludrocortisone|DRUG: Eplerenone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Simultaneous Multiple Cruciate Ligament Reconstructions Using a Single Achilles Allograft
Status: COMPLETED
Conditions: Rupture of Posterior Cruciate Ligament|Rupture of Anterior Cruciate Ligament
Interventions: PROCEDURE: cruciate ligament reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Drug Monitoring of Sunitinib and Pazopanib in Advanced or Metastatic Renal Cell Carcinoma
Status: COMPLETED
Conditions: Metastatic Renal Cell Cancer
Interventions: DRUG: Pazopanib|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Butylphthalide for Preventing Restenosis After Intracranial and Extracranial Artery Stenting
Status: COMPLETED
Conditions: Restenosis
Interventions: DRUG: Butylphthalide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Primary Care Study With Chondroitin Sulfate and Glucosamine Hydrochloride in Hand Osteoarhritis
Status: UNKNOWN
Conditions: Hand Osteoarthritis
Interventions: DRUG: Droglican|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of the Effect of Antimicrobial Soap on Bacterial Survival
Status: COMPLETED
Conditions: Survival of Bacteria on Skin After Using Different Soaps
Interventions: OTHER: Antibacterial soap with triclocarban|OTHER: Antibacterial soap + benzalkonium chloride|OTHER: Control soap
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: STOP-HER2: Stopping Trastuzumab in HER2+ MBC
Status: RECRUITING
Conditions: Breast Cancer|Metastatic Breast Cancer|HER2-positive Breast Cancer
Interventions: OTHER: Cessation of anti-HER2 treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MAGnesium-based Bioresorbable Scaffold in ST Segment Elevation Myocardial Infarction
Status: COMPLETED
Conditions: Acute Coronary Syndrome|ST Segment Elevation Myocardial Infarction|Stent
Interventions: DEVICE: Percutaneous coronary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Clinical Outcomes of Warmed Embryo Vitrified at 2PN Stage and Fresh Embryo Transfers
Status: UNKNOWN
Conditions: Infertility, Female|Reproductive Disorder
Interventions: DIAGNOSTIC_TEST: progesterone|DIAGNOSTIC_TEST: day 3 embryo
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Optimizing Functional Recovery of Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer Female
Interventions: BEHAVIORAL: The Behavioral Activation/ Problem Solving Intervention|BEHAVIORAL: Attention Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Duloxetine on Pathological Worry in Patients With Generalized Anxiety Disorder: A fMRI Study
Status: TERMINATED
Conditions: Worry|Anxiety
Interventions: DRUG: duloxetine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vitamin D Supplementation in Cirrhotic Patients
Status: COMPLETED
Conditions: Cirrhosis|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D supplementation|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial of Bupropion Versus Placebo for Methamphetamine Abuse in Adolescents
Status: COMPLETED
Conditions: Adolescent Methamphetamine Abuse
Interventions: DRUG: Bupropion SR 150mg tabs|DRUG: Placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Predictive Factors of Success of Hysteroscopic Endometrial Ablation/Resection
Status: COMPLETED
Conditions: Uterine Bleeding|Treatment Failures|Prognostic Factors
Interventions: PROCEDURE: Endometrial Ablation|PROCEDURE: Repeated gynecological procedure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bispectral Index Guiding Etomidate Used in Children Aged 3 to 10 for Clinical Anesthesia Induction
Status: UNKNOWN
Conditions: Bispectral Index|Pediatric|Etomidate|Induction
Interventions: DRUG: etomidate|DRUG: propofol|DRUG: sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebral Oximetry and Neurological Outcomes in Aortic Arch Surgery Patients
Status: COMPLETED
Conditions: Postoperative Cognitive Dysfunction
Interventions: DEVICE: INVOS Somanetics Cerebral Oximeter|DEVICE: INVOS Somanetics Cerebral Oximeter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Thoracic Epidural Reduces Risks of Increased Left Ventricular Mass Index During Coronary Artery Bypass Graft Surgery
Status: COMPLETED
Conditions: Ischemia Coronary Artery Origin
Interventions: DEVICE: thoracic epidural
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Multicenter Study of Iomeron®-400 Used With Multi-detector Computed Tomography Angiography (MDCTA)
Status: COMPLETED
Conditions: Aortic Disorders|Carotid Disease|Pulmonary Disease|Peripheral Artery Disease
Interventions: OTHER: Iomeron
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Hypertension Prevention Program, Implementation and Scale up- a Hybrid Effectiveness Implementation Study
Status: UNKNOWN
Conditions: Hypertension|Dietary Modification|Health Behavior
Interventions: BEHAVIORAL: Behavioral Intervention Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oral Administration of Four Lactobacillus Species Preparation to Improve the Quality of the Neovaginal Flora in Male to Female Transsexual Patients
Status: COMPLETED
Conditions: Reduction or Absence of Lactobacilli in Neovaginal Flora
Interventions: DIETARY_SUPPLEMENT: Probiotics|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Propolis Mouthwash on Gingivitis
Status: COMPLETED
Conditions: Gingivitis
Interventions: DRUG: Placebo mouthwash|DRUG: Propolis mouthwash|DRUG: Chlorhexidine mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Uncut Roux-en-Y Gastrojejunostomy for Early Gastric Cancer Patients
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: PROCEDURE: Conventional Roux-en-Y Gastrojejunostomy|PROCEDURE: Uncut Roux-en-Y Gastrojejunostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Non-inferiority Study of Eyestil® Plus Multidose Versus Vismed Multi®
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DEVICE: Eyestil Plus®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Mefloquine Prophylaxis in HIV-1 Individuals: a Randomized Placebo-controlled Trial
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: mefloquine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Multicenter Controlled Study to Evaluate Efficacy and Safety of Focused Ultrasound Device (FUBA5200) for Noninvasive Fat Reduction
Status: RECRUITING
Conditions: Body Sculpting
Interventions: DEVICE: Non Invasive Ultrasound (FUBA5200)|DEVICE: Non Invasive Ultrasound (Contour I V3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GlideScope Video Laryngoscope Versus Fiberoptic Intubation
Status: COMPLETED
Conditions: Oral Intubation
Interventions: DEVICE: Intubation with Fiberoptic laryngoscope|DEVICE: GlideScope® Video Laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Long Term Implications of Rare Brain Tumours'
Status: COMPLETED
Conditions: Quality of Life|Cognitive Impairment|WHO Grade II Oligodendroglial Tumor|WHO Grade III Oligodendroglial Tumor|Long-term Effects of Cancer Treatment|Health-related Quality of Life
Interventions: OTHER: Health-related Quality of Life|OTHER: Psychological Distress|OTHER: Fatigue|OTHER: Cognitive Functioning
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess Alpha DaRT224 for the Treatment of Men With Non-metastatic Locally Recurrent Prostate Cancer
Status: RECRUITING
Conditions: Non-metastatic Prostate Cancer|Locally Recurrent Prostate Cancer
Interventions: DEVICE: Experimental: DaRT seeds
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ventilation and Gastric Insufflation During Three Levels of Inspiratory Pressure During Mask Ventilation
Status: UNKNOWN
Conditions: Gastric Ultrasonography|Gastric Insufflation|Mask Ventilation
Interventions: OTHER: peak inspiratory pressure 10 cmH2O|OTHER: peak inspiratory pressure 15 cmH2O|OTHER: peak inspiratory pressure 20 cmH2O
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase II Trial of Preoperative Chemotherapy for Biliary Tract Cancer (BTC) With Node Metastasis
Status: UNKNOWN
Conditions: Biliary Tract Cancer
Interventions: DRUG: Gemcitabine, Cisplatin, S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRS-343 in Combination With Atezolizumab in HER2-Positive Solid Tumors
Status: COMPLETED
Conditions: HER2-positive Breast Cancer|HER2-positive Gastric Cancer|HER2-positive Bladder Cancer|HER2-positive Solid Tumor
Interventions: DRUG: PRS-343 in Combination with Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Understanding How Powered Componentry Impacts K2-Level Transfemoral Amputee Gait
Status: RECRUITING
Conditions: Amputation|Amputation, Traumatic|Amputation of Knee|Amputation; Traumatic, Limb
Interventions: DEVICE: Ottobock CLeg4 + Ottobock foot|DEVICE: SRALAB Hybrid Knee + Polycentric Ankle|DEVICE: SRALAB Hybrid Knee + Passive Ankle|DEVICE: Ottobock CLeg 4 + Polycentric Ankle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Is MIO-RSA Noninferior to BIO-RSA When it Comes to Mechanical Implant Stability?
Status: RECRUITING
Conditions: Arthroplasty Complications|Shoulder Osteoarthritis
Interventions: PROCEDURE: BIO-RSA|PROCEDURE: MIO-RSA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 5-HTP in Patients With IBD in Clinical and Biologic Remission:Effect on Fatigue Scores
Status: COMPLETED
Conditions: Crohn Disease|Ulcerative Colitis|Fatigue|Remission
Interventions: DRUG: 5-HTP|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dendritic Cells Plus Autologous Tumor RNA in Uveal Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Uveal Melanoma
Interventions: BIOLOGICAL: Autologous Dendritic Cells loaded with autologous Tumor RNA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label, Multi-Center Clinical Trial of Eculizumab in Pediatric Patients With Atypical Hemolytic-Uremic Syndrome
Status: COMPLETED
Conditions: Atypical Hemolytic-Uremic Syndrome
Interventions: DRUG: Eculizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of an Infant Formula Supplemented With Galacto-oligosaccharides (GOS)
Status: COMPLETED
Conditions: Nutritional Safety
Interventions: OTHER: Infant formula (with GOS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Communication Strategies to Introduce Psychology Services
Status: COMPLETED
Conditions: Malignant Neoplasms of Independent (Primary) Multiple Sites
Interventions: BEHAVIORAL: Questionnaires|OTHER: Video Presentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of 3 Doses of MOTREM in Patients With Septic Shock
Status: COMPLETED
Conditions: Shock, Septic
Interventions: DRUG: MOTREM|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Fentanyl Analgesia on the Accuracy of HVPG Measurements in Patients With Portal Hypertension
Status: RECRUITING
Conditions: Liver Cirrhosis|Portal Hypertension|Pain
Interventions: DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Ibrutinib Plus FCR in Previously Untreated, Younger Patients With Chronic Lymphocytic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Leukemia
Interventions: DRUG: Ibrutinib|DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of High-intensity Laser Therapy in Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Osteoarthritis|Laser Therapy|Muscle Strength
Interventions: OTHER: high-intensity laser therapy|OTHER: sham high-intensity laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neurophysiological Molecular and Developmental Analysis of the Glutamate Synapse in Autism
Status: COMPLETED
Conditions: Autism
Interventions: GENETIC: analysis of the glutamate synapse in autism|GENETIC: DNA collection|OTHER: Auditory evoked potentials
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: An Efficacy and Safety Comparison Study of Two Marketed Drugs in Patients With Relapsing-remitting MS
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Betaferon/Betaseron|DRUG: Betaferon/Betaseron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Establishment of the Human Intestinal and Salivary Microbiota Biobank - Gastrointestinal Diseases
Status: COMPLETED
Conditions: Clostridium Difficile Infection|Multi Drug Resistant Organisms|Chronic Inflammatory Bowel Disease|Irritable Bowel Syndrome|Hepatic Encephalopathy
Interventions: OTHER: Biological sample collection|OTHER: Questionnaire|OTHER: Medical examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pilot Study Comparing the Immunogenicity of Fendrix vs. Double-dose Engerix B in HIV-infected Non-responders to Standard Hepatitis B Vaccination Courses
Status: COMPLETED
Conditions: HIV|Communicable Diseases|Hepatitis B|HBV|Infectious Diseases
Interventions: DRUG: Engerix B|DRUG: Fendrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Characteristics of Different Types of Safety Lancets on Blood Volume and Perceived Pain in Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Acti-Lance Lite|DEVICE: Acti-Lance Universal|DEVICE: Acti-Lance Special|DEVICE: Medlance Plus Super Lite|DEVICE: Medlance Plus Lite|DEVICE: Medlance Plus Universal|DEVICE: Medlance Plus Extra|DEVICE: Medlance Plus Special|DEVICE: Prolance Micro Flow|DEVICE: Prolance Low Flow|DEVICE: Prolance Normal Flow|DEVICE: Prolance High Flow|DEVICE: Prolance Max Flow|DEVICE: Prolance Pediatric|DEVICE: MediSafe Solo 29 Gauge|DEVICE: MediSafe Solo 23 Gauge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Evaluation of the Retina in Patients With Non-proliferative Diabetic Retinopathy After Aflibercept Injection in the Eye
Status: WITHDRAWN
Conditions: Retinopathy, Diabetic
Interventions: DRUG: Aflibercept Injection|DRUG: Sham injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Follow-up Measurement of Brain PDE10A Enzyme Levels in Huntington´s Disease Gene Expansion Carriers
Status: COMPLETED
Conditions: Huntington's Disease
Interventions: RADIATION: Radioligand [18F]MNI-659
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Local Anesthesia Before Arterial Puncture for Blood Gas Analysis
Status: COMPLETED
Conditions: Indication of Blood Gas Analysis by Radial Artery Blood Sampling
Interventions: DRUG: Placebo|DRUG: lidocaïne/prilocaïne 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Norwegian Trial Comparing Treatment Strategies for Carpal Tunnel Syndrome
Status: RECRUITING
Conditions: Carpal Tunnel Syndrome
Interventions: PROCEDURE: Surgical carpal tunnel release|DRUG: Injection, Triamcinolone Hexacetonide, Per 5 Mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coronavirus Induced Acute Kidney Injury: Prevention Using Urine Alkalinization
Status: TERMINATED
Conditions: COVID|Coronavirus|Coronavirus Infection|AKI|Acute Kidney Injury
Interventions: DRUG: Sodium bicarbonate|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TAA6 Cell Injection In The Treatment of Patients With Relapsed / Refractory Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: CAR|Acute Myeloid Leukemia
Interventions: OTHER: Chimeric antigen receptor T cells (car-t)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Post-operative Antibacterial Therapy in Complicated Appendicitis: Oral Versus Intravenous
Status: UNKNOWN
Conditions: Acute Appendicitis|Acute Appendicitis With Rupture|Acute Appendicitis Without Peritonitis|Acute Appendicitis With Appendix Abscess|Appendicitis; Perforation|Appendicitis Perforated|Appendicitis Acute
Interventions: OTHER: Oral versus intravenous administration of antibacterial treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microglial Activation in Narcolepsy Type 1 and Kleine-Levin Syndrome: Positron Emission Tomography (PET) Study in [18F] DPA-714
Status: COMPLETED
Conditions: Narcolepsy 1|Kleine-Levin Syndrome
Interventions: RADIATION: PET scan with tracer injection [18F] DPA-714
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Effect of Rhythmic Sensory Stimulation on Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: Rhythmic Sensory Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety and Primary Immunogenicity of Cell-free (Three-component) Combination Vaccine for Phase I Immunogenicity in Children and Infants
Status: UNKNOWN
Conditions: Safety、Immunogenicity
Interventions: BIOLOGICAL: A single-center and single-arm design was used to evaluate the safety and preliminary immunogenicity of the adsorbed cell-free leukiche (three-component) combination vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Efficacy and Safety of Filgotinib in Participants With Active Psoriatic Arthritis Who Are Naive to Biologic DMARD Therapy
Status: TERMINATED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Filgotinib|DRUG: Adalimumab|DRUG: Placebo to match filgotinib|DRUG: Placebo to match adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CureOne Registry: Advanced Malignancy or Myelodysplasia, Tested by Standard Sequencing and Treated by Physician Choice
Status: TERMINATED
Conditions: Neoplasms|Lung Neoplasms|Colon Neoplasms|Breast Neoplasms|Pancreatic Neoplasms|Prostate Neoplasms|Kidney Neoplasms|Liver Neoplasms|Rectal Neoplasms|Hematologic Neoplasms|Multiple Myeloma|Myelodysplastic Syndromes|Ovarian Neoplasms|Bladder Neoplasms|Testicular Neoplasms|Endometrial Neoplasms|Brain Neoplasms|Biliary Tract Neoplasms|Head and Neck Neoplasms|Uterine Cervical Neoplasms|Skin Neoplasms|Melanoma|Gastric Neoplasms|Anal Neoplasms|Sarcoma
Interventions: OTHER: Provider determined
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Dose Escalation Study of Adavosertib (MK-1775) in Combination With Either Gemcitabine, Cisplatin, or Carboplatin in Adults With Advanced Solid Tumors (MK-1775-001)
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: adavosertib|DRUG: gemcitabine|DRUG: cisplatin|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CYPHP Evelina London Evaluation
Status: COMPLETED
Conditions: Asthma|Eczema|Constipation
Interventions: OTHER: CYPHP Evelina London Model of care|OTHER: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy of Two Dosages of Inhaled TPI ASM8 Compared to Placebo in Mild to Moderate Asthmatic Patients
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: TPI ASM8|DRUG: ASM8
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Encapsulated Juice Powder Concentrate for Preventing Common Cold Symptoms
Status: COMPLETED
Conditions: Common Cold
Interventions: DIETARY_SUPPLEMENT: Juice Plus|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Study to Assess the Quantitative Dermal Transfer Efficiencies of Solids for Multiple Transfer Pathways
Status: COMPLETED
Conditions: Environmental Exposure
Interventions: OTHER: Participants for Surface Skin Sampling|OTHER: Elemental metallic lead|OTHER: Tinopal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Randomized, Multicenter, Double-Blind, Parallel-Group, Placebo-Controlled Trial of the Efficacy and Safety of Bovine Anti-Cryptosporidium Immunoglobulin (BACI) in the Treatment of Cryptosporidium Enteritis in AIDS Patients
Status: COMPLETED
Conditions: Cryptosporidiosis|HIV Infections
Interventions: DRUG: Cryptosporidium Immune Whey Protein Concentrate (Bovine)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study for Efficacy of Anti-Corona VS2 Immunoglobulins Prepared From COVID19 Convalescent Plasma Prepared by VIPS Mini-Pool IVIG Medical Devices in Prevention of SARS-CoV-2 Infection in High Risk Groups as Well as Treatment of Early Cases of COVID19 Patients
Status: UNKNOWN
Conditions: COVID19
Interventions: OTHER: hyper immunoglobulins containing anti-Corona VS2 immunoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comprehensive Bladder Preservation Therapy on Patients With Muscle Invasive Bladder Cancer
Status: NOT_YET_RECRUITING
Conditions: Urinary Bladder Neoplasms
Interventions: DRUG: Tislelizumab Injection|PROCEDURE: Transurethral resection of bladder tumor|RADIATION: Adjuvant radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Setting up a Website in Paediatric Surgery at the Rouen University Hospital for Parents and Children to Better Understand the Postoperative Prescription of Painkillers.
Status: UNKNOWN
Conditions: Paediatric Surgery|Analgesics Prescriptions
Interventions: OTHER: Website access
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Frailty in Patients With Cirrhosis: Prognostic Value of the Phase Angle in Hospitalized Patients and Effect of Multifactorial Intervention
Status: COMPLETED
Conditions: Cirrhosis of the Liver|Sarcopenia|Frailty Syndrome
Interventions: COMBINATION_PRODUCT: Home exercise program for 12 months.|COMBINATION_PRODUCT: Multispecies probiotic: Vivomixx®|COMBINATION_PRODUCT: Branched-chain amino acids (BCAA)|COMBINATION_PRODUCT: No specific intervention.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 99mTc-QULIC-5-P1 SPECT Imaging in Patients With Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer Stage|PSMA|SPECT
Interventions: DRUG: 99mTc-QULIC-5-P1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: FS-1502 Versus T-DM1 for HER2-Positive Unresectable Locally Advanced or Metastatic Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: BIOLOGICAL: Investigational drug: Recombinant Anti-HER2 Humanized Monoclonal Antibody - Monomethyl Auristatin F Conjugates for Injection (FS-1502)|BIOLOGICAL: Control drug: Trastuzumab emtansine (Kadcyla, T-DM1)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritional Cognitive Behavioral Therapy Feasibility Study in NAFLD and NASH
Status: COMPLETED
Conditions: Non-alcoholic Steatohepatitis|Non-Alcoholic Fatty Liver Disease|Non-alcoholic Fatty Liver
Interventions: DEVICE: BT-NCBT-00X
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation
Interventions: DRUG: Amiodarone|DRUG: Minocycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Collagen Scaffolds Loaded With HUCMSCs for the Improvement of Erectile Function in Men With Diabetes
Status: WITHDRAWN
Conditions: Erectile Dysfunction|Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus
Interventions: BIOLOGICAL: HUCMSC injection|BIOLOGICAL: collagen scaffolds/HUCMSC injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Defining the Utility of PET/CT in the Follow-up of Patients With Solid Tumors
Status: TERMINATED
Conditions: Cancer Recurrence|Solid Tumors
Interventions: PROCEDURE: PET/CT|PROCEDURE: NCCN recommendations for solid tumor post treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Dose Ranging Study of Ivermectin Treatment Conditioner in Subjects With Head Lice Infestation
Status: COMPLETED
Conditions: Pediculus Humanus Capitis (Head Lice)
Interventions: DRUG: ivermectin treatment conditioner|DRUG: Placebo, vehicle control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Toradol on Post-operative Foot and Ankle Healing
Status: COMPLETED
Conditions: Ankle Fractures|Trauma Injury
Interventions: DRUG: Ketorolac|OTHER: No ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b Open Label, Dose Escalation Study of PLX3397 in Combination With Vemurafenib in V600-mutated BRAF Melanoma
Status: TERMINATED
Conditions: V600-mutated BRAF Unresectable Melanoma|V600-mutated BRAF Metastatic Melanoma|Stage III or Stage IV Metastatic Melanoma That Has Not Been Previously Treated With a Selective BRAF Inhibitor
Interventions: DRUG: PLX3397|DRUG: vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Niraparib and TSR-042 for the Treatment of BRCA-Mutated Unresectable or Metastatic Breast, Pancreas, Ovary, Fallopian Tube, or Primary Peritoneal Cancer
Status: RECRUITING
Conditions: Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|BRCA-Associated Malignant Neoplasm|BRCA-Associated Ovarian Carcinoma|Metastatic BRCA-Associated Breast Carcinoma|Metastatic Breast Carcinoma|Metastatic Fallopian Tube Carcinoma|Metastatic Malignant Solid Neoplasm|Metastatic Ovarian Carcinoma|Metastatic Pancreatic Carcinoma|Metastatic Primary Peritoneal Carcinoma|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IV Breast Cancer AJCC v8|Stage III Fallopian Tube Cancer AJCC v8|Stage III Ovarian Cancer AJCC v8|Stage III Pancreatic Cancer AJCC v8|Stage III Primary Peritoneal Cancer AJCC v8|Stage IV Fallopian Tube Cancer AJCC v8|Stage IV Ovarian Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8|Stage IV Primary Peritoneal Cancer AJCC v8|Unresectable Breast Carcinoma|Unresectable Fallopian Tube Carcinoma|Unresectable Malignant Solid Neoplasm|Unresectable Ovarian Carcinoma|Unresectable Pancreatic Carcinoma|Unresectable Primary Peritoneal Carcinoma
Interventions: BIOLOGICAL: Dostarlimab|DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Donor Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Adult B Acute Lymphoblastic Leukemia|Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|Adult L1 Acute Lymphoblastic Leukemia|Adult L2 Acute Lymphoblastic Leukemia|Adult T Acute Lymphoblastic Leukemia|Recurrent Adult Acute Lymphoblastic Leukemia
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Dasatinib|DRUG: Dexamethasone|DRUG: Doxorubicin Hydrochloride|DRUG: Etoposide|BIOLOGICAL: Filgrastim|OTHER: Laboratory Biomarker Analysis|DRUG: Leucovorin Calcium|DRUG: Methotrexate|DRUG: Methylprednisolone|PROCEDURE: Peripheral Blood Stem Cell Transplantation|DRUG: Prednisone|DRUG: Sirolimus|DRUG: Tacrolimus|RADIATION: Total-Body Irradiation|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of AMDX-2011P in Participants With Primary Open Angle Glaucoma
Status: RECRUITING
Conditions: Primary Open Angle Glaucoma
Interventions: DRUG: AMDX-2011P
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Midodrine for Improving Hemodynamics After Spinal Anesthesia
Status: COMPLETED
Conditions: Hypotension After Spinal Anesthesia
Interventions: DRUG: Midodrine Oral Product|DRUG: Inert tablet containing sugar (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The P.A.U.S.E.® Spectacle Study
Status: NOT_YET_RECRUITING
Conditions: Myopia
Interventions: DEVICE: Single vision spectacle lens|DEVICE: P.A.U.S.E. spectacle lens 1|DEVICE: P.A.U.S.E. spectacle lens 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System
Status: COMPLETED
Conditions: Chronic Pain|Low Back Pain|Radiculopathy|Complex Regional Pain Syndrome (CRPS)
Interventions: OTHER: High frequency stimulation|OTHER: Low frequency stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of rTMS for Cognitive Rehabilitation in Moyamoya Disease
Status: UNKNOWN
Conditions: Moyamoya Disease
Interventions: DEVICE: Transcranial Magnetic Stimulation|DEVICE: Sham Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of an Immersive Virtual Reality Intervention Combined With Mindfulness-based Stress Reduction
Status: COMPLETED
Conditions: Stress|COVID-19 Pandemic|Nurse's Role
Interventions: DEVICE: Therapeutic VR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of PDR001 and/or MBG453 in Combination With Decitabine in Patients With AML or High Risk MDS
Status: COMPLETED
Conditions: Leukemia|Leukemia, Myeloid|Leukemia, Myeloid, Acute|Myelodysplastic Syndromes|Preleukemia|Bone Marrow Diseases|Hematologic Diseases|Chronic Myelomonocytic Leukemia
Interventions: DRUG: Decitabine|DRUG: PDR001|DRUG: MBG453|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chinese Tuina Therapy for Treatment of Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: OTHER: Chinese Tuina therapy|OTHER: Physical Manual therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Staging Prostate Cancer With Hybrid C11-Choline PET/MR and mpMRI
Status: COMPLETED
Conditions: Prostate Adenocarcinoma
Interventions: DRUG: C-11 choline PET tracer|DRUG: Gadobutrol|DEVICE: PET/MR scanner
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: 18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Subjects With Hyperinsulinemic Hypoglycemia
Status: AVAILABLE
Conditions: Congenital Hyperinsulinism (CHI)|Beckwith-Wiedemann Syndrome|Insulinoma
Interventions: DRUG: 18F-DOPA
Study Type: EXPANDED_ACCESS
Clinical trial: Investigation in Myositis-associated Pneumonitis of Prednisolone And Concomitant Tacrolimus
Status: COMPLETED
Conditions: Interstitial Pneumonitis|Polymyositis|Dermatomyositis
Interventions: DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients
Status: COMPLETED
Conditions: Vaginitis Atropic|Pelvic Organ Prolapse|Endometrial Hyperplasia
Interventions: DRUG: Conjugated Estrogen|DRUG: Promestriene|DRUG: Estriol|DRUG: Vaginal Moisturizer - Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pilot Study of Novel Fluorescence Endoscopic Device for Sentinel Lymph Node Mapping in Lung Cancer
Status: WITHDRAWN
Conditions: Lung Cancer
Interventions: DRUG: Indocyanine green (ICG)|DEVICE: FluoSCOPE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioequivalence Study of Galantamine 4 mg Tablet and Reminyl Following a 4 mg Dose in Healthy Subjects Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Galantamine 4 mg Tablet, single dose|DRUG: Reminyl 4 mg Tablet, single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy Study of Antiemetics to Reduce Postoperative Nausea and Vomiting
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Ramosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Pharmacokinetics, Safety, and Tolerability of Single and Multiple Doses of Rasagiline
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Rasagiline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Procalcitonin (PCT) as a Diagnostic Marker of Bacterial Infection in the Patients Admitted for Fever and/or Inflammatory Syndrome to the Internal Medicine Department
Status: COMPLETED
Conditions: Systemic Inflammatory Response Syndrome|Fever
Interventions: BIOLOGICAL: Procalcitonin (PCT) as a diagnostic marker of bacterial infection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p