pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Biliary Drainage Plus HAIC in Locally Advanced pCCA
Status: RECRUITING
Conditions: Perihilar Cholangiocarcinoma
Interventions: DRUG: oxaliplatin and 5-fluorouracil|PROCEDURE: Biliary Drainage|OTHER: Best Supportive Care|PROCEDURE: External biliary drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Therapy (PDT) for Palliation of Cholangiocarcinoma
Status: UNKNOWN
Conditions: Cholangiocarcinoma|Biliary Stricture|Biliary Obstruction|Bile Duct Cancer
Interventions: PROCEDURE: Photodynamic Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study to Evaluate the Performance of Fractional Radiofrequency for Improvement of Skin Texture Via Skin Resurfacing and Wrinkles Reduction
Status: COMPLETED
Conditions: Skin Resurfacing|Wrinkle Reduction
Interventions: DEVICE: Fractional RF treatment with Matrix RF applicator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Very High Power Ablation in Patients With Atrial Fibrillation Scheduled for a First Pulmonary Vein Isolation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Conventional CLOSE-guided pulmonary vein isolation|PROCEDURE: High power short duration pulmonary vein isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REVEAL 1 (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL)
Status: COMPLETED
Conditions: Cervical Dysplasia|Cervical High Grade Squamous Intraepithelial Lesion|HSIL
Interventions: BIOLOGICAL: VGX-3100|BIOLOGICAL: Placebo|DEVICE: Electroporation (EP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post Operative Pain of Partial Pulpotomy Using a Bioceramic Material in Patients With Symptomatic Irreversible Pulpitis
Status: COMPLETED
Conditions: Endodontic Disease
Interventions: PROCEDURE: Partial pulpotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Topical ALT-2074 (SYI-2074) for Treatment of Chronic Plaque Psoriasis
Status: TERMINATED
Conditions: Psoriasis
Interventions: DRUG: 4,4-dimethyl-benziso-2H-selenazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing the Treatment of Toenail Onychomycosis Using a New Transdermal Patch Combined With Terbinafine/Ketoconazole
Status: UNKNOWN
Conditions: Onychomycosis
Interventions: DRUG: 3 mg terbinafine and 2 mg ketoconazole containing patch|DRUG: 6 mg terbinafine and 2 mg ketoconazole containing patch|DRUG: 8 mg terbinafine and 2 mg ketoconazole containing patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study of ZSP1602 in Participants With Advanced Solid Tumors
Status: UNKNOWN
Conditions: Basal Cell Carcinoma|Medulloblastoma|Adenocarcinoma of Esophagogastric Junction|Small Cell Lung Cancer|Neuroendocrine Neoplasm|Glioblastoma
Interventions: DRUG: ZSP1602
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Exercise Frequency on Metabolic Control and Heart Function in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: accumulated exercise|BEHAVIORAL: traditional exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Enoblituzumab (MGA271) in Combination With Pembrolizumab or MGA012 in Refractory Cancer
Status: COMPLETED
Conditions: Melanoma|Head and Neck Cancer|Non Small Cell Lung Cancer|Urethelial Carcinoma
Interventions: BIOLOGICAL: Enoblituzumab|BIOLOGICAL: Pembrolizumab|BIOLOGICAL: MGA012
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Lycopene Supplementation in Prostatic Intraepithelial Neoplasia
Status: COMPLETED
Conditions: Prostatic Intraepithelial Neoplasia
Interventions: DRUG: - Lyc-O-Mato (dietary supplement, 30 mg lycopene/day)|DRUG: - Certagen (multivitamins with minerals)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: MgSO4 as Adjuvants to Bupivacaine vs Neostigmine in TAP Block in Cesarean Section
Status: NOT_YET_RECRUITING
Conditions: Cesarean Section
Interventions: PROCEDURE: transversus abdominis plane (TAP) block in cesarean section|DRUG: Magnesium sulfate|DRUG: Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Drug-drug Interactions (DDIs) of DBPR108 With Warfarin Sodium, Digoxin, Probenecid in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Warfarin sodium tablets|DRUG: Digoxin tablet|DRUG: Probenecid tablets|DRUG: DBPR108 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial on the Antipsychotic Properties of Cannabidiol
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders
Interventions: DRUG: Placebo/Cannabidiol|DRUG: Cannabidiol/Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Developing a Virtual Reality (VR)-Based Prototype for Perioperative Care - a Proof of Concept Study
Status: UNKNOWN
Conditions: Anxiety|Postoperative Pain|Pain, Acute
Interventions: DEVICE: Virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closure of Patent Ductus Arteriosus With Indomethacin or Ibuprofen in Extreme Low Birth Weight Infants
Status: COMPLETED
Conditions: Patent Ductus Arteriosus
Interventions: DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CB-839 (Telaglenastat) in Combination With Talazoparib in Patients With Solid Tumors
Status: TERMINATED
Conditions: Solid Tumor|Clear Cell Renal Cell Carcinoma|TNBC - Triple-Negative Breast Cancer|Colorectal Cancer|CRC|RCC|ccRCC
Interventions: DRUG: CB-839|DRUG: Talazoparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Leukotriene Modulator Montelukast on Cough Variant Asthma
Status: UNKNOWN
Conditions: Asthma
Interventions: DRUG: ICS/LABA|DRUG: Montelukast|DRUG: ICS/LABA and Montelukast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CC-95266 in Participants With Relapsed and/or Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: CC-95266|DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Egg Consumption on Carotenoid Absorption From Co-consumed, Non-Egg Food
Status: COMPLETED
Conditions: Will Consuming Eggs With a Mixed Vegetable Salad Increase Carotenoid Absorption
Interventions: OTHER: Egg consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Chronotherapy in Acute Multiple Sclerosis (MS) Attack
Status: TERMINATED
Conditions: Multiple Sclerosis
Interventions: DRUG: methylprednisolone|DRUG: Sodium chlorid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Environmental Exposure to Heavy Metals, Nanoparticles, and Emergent Contaminants and Risk of Allergic Diseases
Status: NOT_YET_RECRUITING
Conditions: Allergic Contact Dermatitis|Metal Allergy|Food Allergy|Nickel Sensitivity|Nickel; Eczema|Aluminum Allergy|Chromium; Eczema|Functional Gastrointestinal Disorders|Respiratory Injury|Pollution; Exposure|Pollution Related Respiratory Disorder|Environmental Exposure|Environment Related Disease|Environmental Illness|Oxidative Stress|Risk Reduction
Interventions: DIAGNOSTIC_TEST: Collection of environmental, biological, and clinical data
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Text Message Reminders to Health Workers on Malaria, Pneumonia, and Diarrhea Case Management in Malawi
Status: COMPLETED
Conditions: Malaria|Pneumonia|Diarrhea
Interventions: BEHAVIORAL: Malaria text message reminders to health workers|BEHAVIORAL: Malaria, pneumonia, and diarrhea text message reminders to health workers|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Vitamin K and Glucose Metabolism in Children at Risk for Diabetes (Vita-K 'n' Kids Study)
Status: UNKNOWN
Conditions: Obesity|Insulin Resistance|Insulin Sensitivity|Prediabetes|Dyslipidemia|Diabetes
Interventions: DIETARY_SUPPLEMENT: Placebo-Control|DIETARY_SUPPLEMENT: Low-Dose Vitamin K2 (menaquinone-7; 45 mcg/d)|DIETARY_SUPPLEMENT: High-Dose Vitamin K2 (menaquinone-7; 90 mcg/d)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SodiUm Burden Lowered by Lifestyle Intervention: Self-Management and E-health Technology
Status: COMPLETED
Conditions: Chronic Kidney Disease|Unspecified Complication of Kidney Transplant
Interventions: BEHAVIORAL: Intervention SUBLIME
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Natural History in Children up to 10 Years With Moderate to Profound Hearing Loss Due to Mutations in GJB2 / OTOF Genes
Status: RECRUITING
Conditions: Sensorineural Hearing Loss, Bilateral|AUNB1|DFNB1A|Congenital Deafness|DFNB9|OTOF Gene Mutation|GJB2 Gene Mutation
Interventions: OTHER: Pure Tone Audiometry Assessment|OTHER: Quality of Life Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical-biological Prospective Cohort of Patients With BRAFV600E-mutated Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer|BRAF V600E Mutation Positive
Interventions: OTHER: Collection of blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Randomized Trial of an Intensive Education Intervention Using a Network of Involved Diabetic Patients (Peer Educators) to Improve Glycemic Control of Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Diabetes
Interventions: OTHER: intensive education intervention using a network of involved diabetic patients (peer educators)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Multifunctional Image Guided Therapy Suite (MIGTS) in Emergency Multiple Trauma Care
Status: COMPLETED
Conditions: Acceleration of Procedure|Reduction of Number of Transports and Transfers|Involved Staff Member's Evaluation
Interventions: PROCEDURE: MIGTS treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Surface Antigen, Inactivated, Influenza Vaccine Using the Strain Composition 2008/2009
Status: COMPLETED
Conditions: Seasonal Influenza
Interventions: BIOLOGICAL: Influenza Vaccine, Formulation 2008-2009
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Randomized Sizing and Hemodynamic Study Mitroflow vs. Magna
Status: TERMINATED
Conditions: Aortic Valve Disease
Interventions: DEVICE: Mitroflow Aortic Pericardial Heart Valve (CarboMedics)|DEVICE: Carpentier-Edwards Magna Tissue Valve
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Toxicity of Increasing Doses of Idarubicin, Cytarabine and G-CSF in Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Di Novo Acute Myeloid Leukemia
Interventions: DRUG: Idarubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect and Cost-utility of of High Intensity vs. Low Intensity Speech Intervention in Children With Cleft Palate
Status: NOT_YET_RECRUITING
Conditions: Cleft Palate Children|Speech Therapy|Speech Disorders in Children|Cleft Lip and Palate
Interventions: BEHAVIORAL: High intensive combined phonetic-phonological intervention|BEHAVIORAL: Low intensive combined phonetic-phonological intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate and Hydroxyurea in Treating Patients With Recurrent or Progressive Meningioma
Status: COMPLETED
Conditions: Glioblastoma|Gliosarcoma
Interventions: DRUG: hydroxyurea|DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study to Assess Safety and Pharmacokinetics of GMI-1271 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: GMI-1271|DRUG: Placebo|DRUG: Enoxaparin Sodium (Lovenox®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate a Nutraceutical Supplement for Treatment of Hair Loss and Thinning in Females
Status: COMPLETED
Conditions: Hair Loss
Interventions: DIETARY_SUPPLEMENT: Nutrafol|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Dyskinesia in Parkinson's Disease With Omega-3 Fatty Acids
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Docosahexaenoic Acid (DHA)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison of Glucose Values and Variability Between TOUJEO and TRESIBA During Continuous Glucose Monitoring in Type 1 Diabetes Patients
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Insulin glargine, 300 U/ml|DRUG: Insulin degludec, 100U/ml|DRUG: Background therapy: Rapid acting insulin analogs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi Peptide Vaccination With XS15 in Addition to Standard Postoperative Radiation Therapy and Temozolomide Chemotherapy in Newly Diagnosed Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma Multiforme of Brain
Interventions: DRUG: Multipeptide plus XS15
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative PSMA PET/CT as Triage for ePLND in Patients Scheduled for RALP (PrePSMA)
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: PSMA PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study Using Rexin-G for Sarcoma
Status: COMPLETED
Conditions: Sarcoma
Interventions: GENETIC: Rexin-G|GENETIC: Rexin-G|GENETIC: Rexin-G|GENETIC: Rexin-G|GENETIC: Rexin-G
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Evaluation of Tapentadol Extended Release (ER) in Participants With Moderate to Severe Chronic Pain After Conversion From Hydrocodone, Oxycodone Controlled Release (CR), and/or Morphine Sustained Release (SR)
Status: WITHDRAWN
Conditions: Pain|Chronic Back Pain|Chronic Low Back Pain|Osteoarthritis Pain In The Hip or Knee
Interventions: DRUG: Nucynta ER
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety Study of Canagliflozin (TA-7284) in Combination With Insulin in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Canagliflozin (TA-7284)|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Filler Agent Composed of Umbilical Cord Mesenchymal Stem Cells and Hyaluronic Acid
Status: UNKNOWN
Conditions: Senescence Wrinkles, Acne, Pitting Scar
Interventions: BIOLOGICAL: umbilical cord mesenchymal stem cells and hyaluronic acid|DRUG: hyaluronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Collaborative Care Model for Allergic Rhinitis With Obstructive Sleep Apnea From Prevention to Treatment.
Status: UNKNOWN
Conditions: Pediatric Sleep Apnea
Interventions: DEVICE: laser acupuncture (RJ laser S/N 1813458)|DRUG: western medicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Voiding School as a Treatment of Children's Day-time Incontinence or Enuresis
Status: WITHDRAWN
Conditions: Daytime Wetting|Enuresis|Functional Incontinence
Interventions: BEHAVIORAL: Voiding school
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Complication Rates Associated With Robot-assisted Thyroidectomy to External Thyroidectomy
Status: TERMINATED
Conditions: Thyroid Nodule|Goiter|Thyroiditis|Graves Disease
Interventions: PROCEDURE: Robot-assisted thyroidectomy|PROCEDURE: Open thyroidectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Direct Improvement of Quality of Life Using a Tailored Pathway With Quality of Life Diagnosis and Therapy: Randomised Trial in Colorectal Cancer Patients
Status: COMPLETED
Conditions: Quality of Life|Colorectal Neoplasms
Interventions: BEHAVIORAL: quality of life pathway|OTHER: placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effects of NSAIDs on Bone Metabolism Following Exercise
Status: COMPLETED
Conditions: Bone Resorption|Stress Fracture|Bone Injury
Interventions: DRUG: Ibuprofen 800 mg|DRUG: Celecoxib 200mg|DRUG: Flurbiprofen 100 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Identification and Standardization of a Method That Would Allow the Study of the Metabolic Profile of Blastocoele Lays the Foundation to Assess Blastocyst Metabolomic Profile and Its Relation With Embryo Morphology and Embryo Implantation
Status: UNKNOWN
Conditions: Blastocoele Fluid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Study to Assess the Efficacy and Safety of SED80 for Use in Cataract Surgery
Status: COMPLETED
Conditions: Cataract in Inflammatory Ocular Disorders
Interventions: DRUG: Dexamethasone Dose 1|DRUG: Dexamethasone Dose 2|DRUG: Placebo Dose 1|DRUG: Placebo Dose 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Low-dose Atropine on Sympathetic Blockade in Spinal Cesarean Section Patients
Status: COMPLETED
Conditions: Pregnancy|Cesarean Section|Anesthesia, Spinal
Interventions: DRUG: Slow dose preemptive Atropine|DRUG: Ephedrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Self-care Intervention for Depression in Primary Care Patients With Chronic Physical Illnesses
Status: COMPLETED
Conditions: Depression|Chronic Disease
Interventions: BEHAVIORAL: Supported self-care|BEHAVIORAL: Unsupported self-care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Immunogenicity of Nimenrix (Registered) in Healthy Infants, Given at 3 and 12 Months of Age
Status: COMPLETED
Conditions: Meningococcal Vaccine
Interventions: BIOLOGICAL: Nimenrix
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bilateral External Oblique Intercostal Plane Block in Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: External Oblique Intercostal Plane Block|Laparoscopic Cholecystectomy
Interventions: DRUG: local anesthetic injection (bupivacaine)|OTHER: normal saline injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Clinical Evaluation of Therapy™ Cool Flex Ablation Catheter for the Treatment of Paroxysmal Atrial Fibrillation
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: Therapy™ Cool Flex Ablation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Translation of a Novel Albumin-Binding PET Radiotracer 68Ga-NEB
Status: UNKNOWN
Conditions: Arteriovenous Malformation|Hemangioma|Neoplasms Lymph Nodes|Lymphedema
Interventions: DRUG: 68Ga-NEB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Prophylactic Use of Mitomycin C 0.02% to Inhibit Haze Formation After Photorefractive Keratectomy for High Myopia: 15 x 30 Seconds
Status: COMPLETED
Conditions: High Myopia
Interventions: DRUG: PRK and a single intraoperative topical application of mitomycin C 0.02% for 15 seconds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Tolerance, Pharmacokinetics / Pharmacodynamics (PK / PD) and Immunogenicity of Pegylated Uric Acid Oxidase for Injection in Healthy Adults and Hyperuricemia Volunteers
Status: UNKNOWN
Conditions: Hyperuricemia
Interventions: DRUG: Polyglycol lated urate oxidase for injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Herceptin (Trastuzumab) in Women With Human Epidermal Growth Factor Receptor (HER) 2-Positive Advanced and/or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Xeloda|DRUG: Taxotere|DRUG: Herceptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Acupoint Electro-stimulation on Preventing Nausea and Vomiting Induced by Cisplatin or Oxaliplatin
Status: WITHDRAWN
Conditions: Liver Cancer|Liver Metastasis
Interventions: PROCEDURE: Electro-Stimulation of Yongquan (K1) Acupoint|PROCEDURE: Electro-Stimulation of Yongquan (K1) Acupoint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Single and Multiple Ascending Dose Study of CORT125236 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CORT125236|DRUG: Placebo matching CORT125236|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Influence of the Method of Alleviation of Aorto-Caval Compression on the Trans-Hepatic Ultrasound-Assessed Inferior Vena Cava Diameter In Pregnant Patients
Status: COMPLETED
Conditions: Pregnancy|Cardiac Arrest
Interventions: DEVICE: Ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Validation of Digital-PCR Analysis Through Programmed Imatinib Interruption in PCR Negative CML Patients
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Lord´s Procedure Versus Sclerotherapy for Testicular Hydrocele; a Randomized Controlled Study
Status: UNKNOWN
Conditions: Testicular Hydrocele
Interventions: PROCEDURE: Lord´s procedure|PROCEDURE: Sclerotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized HaploCord Blood Transplantation vs. Double Umbilical Cord Blood Transplantation for Hematologic Malignancies
Status: TERMINATED
Conditions: Acute Myelogenous Leukemia|Myelodysplastic Syndrome|Acute Lymphocytic Leukemia|Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma
Interventions: DEVICE: CliniMACS® CD34 Reagent System|DRUG: Fludarabine|DRUG: Melphalan|DRUG: Rabbit ATG|PROCEDURE: Double Umbilical Cord Blood Transplantation|PROCEDURE: Haplo-Identical Cord Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation With Immune Checkpoint Inhibitors in Lung Cancer
Status: RECRUITING
Conditions: Metastatic Lung Cancer
Interventions: DRUG: Antibiotics|OTHER: FMT (Fecal Microbiota Transplantation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Establishment of Social Skills Training Group in Adolescents With Autism Spectrum Disorder and Effectiveness Analysis
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Program for the Education and Enrichment of Relational Skills (PEERS®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Kinesiophobia on the Excitability of Connections Parieto-frontal During a Pointing Movement in Humans
Status: COMPLETED
Conditions: Kinesiophobia|Motor Coordination or Function; Developmental Disorder|Transcranial Magnetic Stimulation|Pain, Acute
Interventions: BEHAVIORAL: Experimental
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Test a Computer-assisted Support System to Improve Patient-centered Care and Symptom Relief in Cancer Patients
Status: COMPLETED
Conditions: Cancer|Lymphoma|Leukemia|Stem Cell Transplantation
Interventions: BEHAVIORAL: Tailored assessments provided to physicians and nurses (CHOICE, the Computer-assisted Interactive Tailored Patient Assessment Tool (ITPA))
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Myo vs. Myofascial Injection for Myofascial Trigger Points
Status: COMPLETED
Conditions: Myofascial Pain|Myofascial Trigger Point Pain|Trigger Point Pain, Myofascial
Interventions: PROCEDURE: myo + fascial injection|PROCEDURE: traditional trigger point injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: University of Pittsburgh Brain Health Initiative
Status: RECRUITING
Conditions: Traumatic Brain Injury
Interventions: DIAGNOSTIC_TEST: Cognitive/Neuropsychological Testing|DIAGNOSTIC_TEST: Vestibular/Ocular-Motor Testing|DIAGNOSTIC_TEST: Sleep Evaluation|DIAGNOSTIC_TEST: MRI, High-Resolution|DIAGNOSTIC_TEST: Health & Physical Exam|DIAGNOSTIC_TEST: Physical Function|DIAGNOSTIC_TEST: Blood Testing and Biomarker Analysis|DIAGNOSTIC_TEST: Applanation Tonometry|DIAGNOSTIC_TEST: PET brain imaging|DRUG: [C-11]6-OH-BTA-1|DRUG: [F-18]AV-1451
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Monotherapy With Levetiracetam in Patients Suffering From Epilepsy.
Status: COMPLETED
Conditions: Epilepsy, Tonic-clonic
Interventions: DRUG: Levetiracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Magnetotherapy in Hand Erosive Osteoarthritis.
Status: COMPLETED
Conditions: Musculoskeletal Disease|Musculoskeletal Pain|Physical Therapy
Interventions: DEVICE: Magnetotherapy device|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of Aqueous and Vitreous Humor
Status: UNKNOWN
Conditions: Proliferative Diabetic Retinopathy|Macular Degeneration|Macular Hole|Neovascular Glaucoma
Interventions: DRUG: Ranibizumab|OTHER: No Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison Of Effectiveness of Transrectal Ultrasonography-Guided Saturation Biopsy And 10-12 Core Biopsy In Repeated Prostate Biopsies
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: Transrectal prostate biopsy with ultrasonography.|PROCEDURE: Periprostatic block|PROCEDURE: Sedoanalgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Plastic vs. Covered Metal vs. Uncovered Metal Biliary Stents for the Management of Malignant Biliary Obstruction
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DEVICE: Biliary stent placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Probiotics in the Treatment of Acute Gastroenteritis in Children
Status: COMPLETED
Conditions: Acute Gastroenteritis
Interventions: BIOLOGICAL: Probiotic : Saccharomyces boulardii|BIOLOGICAL: Probiotic : Bacillus clausii
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Continue ASP015K Treatment to Rheumatoid Arthritis Patients Who Completed Phase IIb Study or Phase III Study of ASP015K
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Peficitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Micro-dose Human Chorionic Gonadotropin (hCG) With Human Menopausal Gonadotropin (HMG) in Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Endocrine System Diseases|Gonadal Disorders
Interventions: DRUG: low dose human chorionic gonadotropin|DRUG: Clomiphen citrate plus HMG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Monitoring Parameters Beyond Glycemic Control: Impact of Sitagliptin on Quality of Life in Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Quality of Life|Type 2 Diabetes|Metformin+Sitagliptin
Interventions: DRUG: Metformin / Sitagliptin Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Implementation of Patient Safety Checklists Before, During and After In-hospital Surgery
Status: COMPLETED
Conditions: Surgery|Safety Issues|Complication|Patient Safety|Health Literacy|Health Economics
Interventions: OTHER: Patient Safety Checklist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder (MDD) (DEPARRESTCLIN)
Status: COMPLETED
Conditions: Major Depressive Disorder|Major Depressive Episode
Interventions: DRUG: Venlafaxine extended release
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benefit of Early Intrauterine Transfer of "Blank" Culture Medium Prior to Transfer of a Thawed Embryo From 1st in Vitro Fertilization
Status: RECRUITING
Conditions: Single Embryo Transfer|Fertilization in Vitro
Interventions: PROCEDURE: Blank culture transfer|PROCEDURE: Sham transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Varenicline for Alcohol Dependence
Status: COMPLETED
Conditions: Alcoholism
Interventions: DRUG: Varenicline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Epidural Volume Extension and Intrathecal Use of Local Anesthetics in Cesarean Sections
Status: UNKNOWN
Conditions: Stillborn Caesarean Section
Interventions: DRUG: Bupivacaine- Fentanyl - Normal Saline|DRUG: Ropivacaine-Fentanyl-Normal Saline|DRUG: Levobupivacaine- Fentanyl- Normal Saline|DRUG: Bupivacaine + Fentanyl|DRUG: Ropivacaine + Fentanyl|DRUG: Levobupivacaine + Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Itraconazole as a Targeted Therapy for Inhibiting Hedgehog Pathway Signaling in Esophageal Cancer Patients
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Extended Release Naltrexone Versus Extended Release Buprenorphine With Individuals Leaving Jail
Status: RECRUITING
Conditions: Opioid-use Disorder
Interventions: DRUG: XR-B|DRUG: XR-NTX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK)
Status: COMPLETED
Conditions: Fuchs' Dystrophy|Bullous Keratopathy
Interventions: DRUG: Prednisolone acetate|DRUG: Fluorometholone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Trial Comparing Morcellation With Electrical Resection for Removal of Uterine Polyps
Status: COMPLETED
Conditions: Endometrial Polyps
Interventions: DEVICE: hysteroscopic morcellator (TruClear)|DEVICE: Bipolar Electrical resectoscope (Versapoint)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sapanisertib in Treating Patients With Locally Advanced or Metastatic Bladder Cancer With TSC1 and/or TSC2 Mutations
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Bladder Urothelial Carcinoma|Metastatic Transitional Cell Carcinoma|Metastatic Urothelial Carcinoma|Recurrent Bladder Carcinoma|Stage III Bladder Urothelial Carcinoma AJCC v6 and v7|Stage IV Bladder Urothelial Carcinoma AJCC v7
Interventions: DRUG: Sapanisertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of an Oxymizer on Endurance Time in Patients With Chronic Lung Diseases
Status: COMPLETED
Conditions: COPD|Interstitial Lung Disease
Interventions: DEVICE: Oxymizer|DEVICE: conventional nasal cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Gemcitabine, Epirubicin, and Paclitaxel Combination Chemotherapy Given Before Surgery to Patients With Locally Advanced Breast Cancer
Status: COMPLETED
Conditions: Stage IIB Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IV Breast Cancer|Breast Cancer|Locally Advanced
Interventions: DRUG: gemcitabine, epirubicin, paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PIRATES: Image-guided Hyper-fractioned Dose-escalation With Proton Therapy for Head and Neck Cancer
Status: NOT_YET_RECRUITING
Conditions: Head and Neck Cancer|Oropharyngeal Cancer
Interventions: RADIATION: Image guided hybrid hyper-fractioned dose escalation with proton therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Five Year Adjuvant Imatinib Mesylate (Gleevec®) in Gastrointestinal Stromal Tumor (GIST)
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumor (GIST)
Interventions: DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ASP-1929 Photoimmunotherapy Combined With Pembrolizumab in Patients With Recurrent Head and Neck Cancer, With or Without Metastases
Status: TERMINATED
Conditions: Head and Neck Cancer
Interventions: COMBINATION_PRODUCT: ASP-1929 Photoimmunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Immunogenicity of Novartis Meningococcal B Recombinant Vaccine Administered to Healthy Adolescents According to Different Vaccination Schedules
Status: COMPLETED
Conditions: Meningococcal Disease
Interventions: BIOLOGICAL: rMenB+OMV NZ|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: WILD 5 Wellness: A 90-Day Intervention (WILD = Wellness Interventions for Life's Demands)
Status: COMPLETED
Conditions: Chronic Pain|Stress, Psychological|Healthy
Interventions: BEHAVIORAL: Wellness Element 1 - Exercise|BEHAVIORAL: Wellness Element 2 - Mindfulness|BEHAVIORAL: Wellness Element 3 - Sleep Hygiene|BEHAVIORAL: Wellness Element 4 - Social Connectedness|BEHAVIORAL: Wellness Element 5 - Nutrition|BEHAVIORAL: Wellness Element 6 - Wellness Exercises|BEHAVIORAL: Wellness Element 7 - Motivational Messages
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Fluoroscopy and CT Guided Radiofrequency Ablation of Thoracic Dorsal Root Ganglia in Severe Thoracic Pain
Status: COMPLETED
Conditions: Cancer-related Problem/Condition
Interventions: PROCEDURE: combined CT-fluroscopy|PROCEDURE: standard fluroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Strawberry Supplementation on Memory and Gait Among Over-weight Older Adults
Status: COMPLETED
Conditions: Aging|Age-related Cognitive Decline|Obesity
Interventions: DIETARY_SUPPLEMENT: Strawberry|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate Efficacy and Safety of NDS-446 in Men With Lower Urinary Tract Symptoms (LUTS)
Status: UNKNOWN
Conditions: Lower Urinary Tract Symptoms
Interventions: DRUG: NDS-446|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Compare ZOLADEX 10.8 mg With ZOLADEX 3.6mg in Chinese Pre-menopausal ER+ HER2- Early Breast Cancer.
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: ZOLADEX 10.8 mg|DRUG: ZOLADEX 3.6mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Volatile Markers in Digestive Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Colorectal Adenoma|Gastric Cancer|Peptic Ulcer Disease|Atrophic Gastritis|Intestinal Metaplasia|H.Pylori Infection|Normal Control|Average-risk General Population
Interventions: PROCEDURE: Breath sampling for volatile marker detection|PROCEDURE: Upper endoscopy with biopsies|PROCEDURE: Colonoscopy with biopsies or lesion removal when required|PROCEDURE: Plasma/serum sampling|PROCEDURE: Faecal sample acquisition|PROCEDURE: Histological evaluation of the surgery material
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Different Ventilatory Strategies on Cardiac Function in Patients With Acute Respiratory Failure
Status: COMPLETED
Conditions: Respiratory Distress Syndrome
Interventions: PROCEDURE: Mechanical ventilation with low and high tidal volume
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Thalidomide, Cyclophosphamide, Oral Idarubicin and Dexamethasone (T-CID) in Patients With Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: thalidomide|DRUG: idarubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of SHR-1701 Plus Bevacizumab and Chemotherapy in Non-Small-Cell-Lung-Cancer
Status: NOT_YET_RECRUITING
Conditions: Advanced or Metastatic Non-squamous Non-small-cell Lung Cancer
Interventions: DRUG: SHR-1701 + Pemetrexed Disodium + cisplatin/carboplatin + bevacizumab|DRUG: Placebo + SHR-1701 + Pemetrexed Disodium+ cisplatin/carboplatin|DRUG: Placebo 1 + Placebo 2 +Pemetrexed Disodium + cisplatin/carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Emergency Department (ED) Flow-directed Fluid Optimization Resuscitation Trial (EFFORT)
Status: TERMINATED
Conditions: Shock
Interventions: DEVICE: Cheetah NICOM® PLRT|DEVICE: USCOM ® (Ultrasound Cardiac Output Monitor)|DEVICE: Inferior Vena Cava (IVC) Ultrasound Collapsibility|BEHAVIORAL: CURVES Questionnaire|BIOLOGICAL: Lactate Clearance|BIOLOGICAL: 500ml Normal Saline Bolus|BIOLOGICAL: Clinician Discretion Intravenous Fluid Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-blind Comparative Study of E3810 Tablets (10 or 20 mg b.i.d.) to Evaluate Efficacy and Safety in Patients With Refractory Reflux Esophagitis
Status: COMPLETED
Conditions: Refractory Reflux Esophagitis
Interventions: DRUG: E3810|DRUG: E3810|DRUG: E3810
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Recovery Capital Amid Opioid Use Disorder Pharmacotherapy: A Pilot Randomized Trial
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder
Interventions: BEHAVIORAL: Recovery Community Center Linkage (RCCL)|BEHAVIORAL: Control Condition (CC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Platelet-rich Plasma in the Treatment of Intractable Postherpetic Neuralgia
Status: COMPLETED
Conditions: PHN - Post-Herpetic Neuritis
Interventions: BIOLOGICAL: ultrasound-guided platelet rich plasma nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect on Acetaminophen Metabolism by Liquid Formulations
Status: COMPLETED
Conditions: Acetaminophen Metabolism|Acetaminophen Poisoning|Drug Metabolism by Excipients
Interventions: DRUG: Acetaminophen liquid formulation|DRUG: Acetaminophen solid formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparing Total Laparoscopic Versus Open Pancreaticoduodenectomy
Status: UNKNOWN
Conditions: Pancreatic Ductal Adenocarcinoma|Surgery|Periampullary Cancer
Interventions: PROCEDURE: Total laparoscopic pancreaticoduodenectomy|PROCEDURE: Open pancreaticoduodenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CHARM-COPD Program of Care
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: Hyfe Smartwatch|DEVICE: FitBit Versa 2|DEVICE: Home Spirometer|BEHAVIORAL: Audio recording
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE