pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety Study of BG00012 With Methotrexate in Patients With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: BG00012|DRUG: BG00012|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Varenicline Treatment of Alcohol Dependence in Smokers
Status: COMPLETED
Conditions: Alcoholism|Alcohol Abuse|Smoking|Alcohol Drinking
Interventions: DRUG: Varenicline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Analgesic Efficiency Between Serratus Block and Paravertebral Block in Video-assisted Thoracic Surgery. Double-blind Randomized Comparative Non-inferiority Study (BSBP)
Status: COMPLETED
Conditions: Anesthesia
Interventions: PROCEDURE: Serratus anesthesia technique|PROCEDURE: Paravertebral anesthesia technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Influence of Sodium Intake on Left Ventricular-arterial Coupling
Status: TERMINATED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: sodium chloride|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Degen Study: Post-market Clinical Follow-up on the PASS LP, PASS Degen and PASS Tulip Systems (PASS DEGEN)
Status: ACTIVE_NOT_RECRUITING
Conditions: Thoracolumbar Disc Degeneration|Thoracolumbar Spondylolisthesis|Spinal Deformity|Spinal Degeneration
Interventions: DEVICE: PASS LP implants|DEVICE: PASS DEGEN|DEVICE: PASS TULIP PRIME
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Natriuresis-Guided Diuretic Therapy in Patients With Acute Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease
Status: NOT_YET_RECRUITING
Conditions: Acute Heart Failure|Chronic Kidney Diseases
Interventions: DRUG: Furosemide 20 MG|OTHER: diuretic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Confirms or Refutes the Hypothesis That the Autologous Bone Marrow Concentrate Together With the Allograft is a Better Alternative for the Posterolateral Fusion in Spine Surgery Than the Allograft Alone
Status: COMPLETED
Conditions: Spondyloarthrosis, Spondylosis
Interventions: BIOLOGICAL: bone allogaft with bone marrow concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: T Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation Conditioned With a Reduced Intensity Regimen in Patients With Hematologic Malignancies and Aplastic Anemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Myeloid Diseases
Interventions: DRUG: Antithymocyte globulin (Rabbit)|DRUG: fludarabine|RADIATION: total body irradiation|DRUG: cyclophosphamide|DRUG: Rituxan|PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Postoperative Analgesic Efficacy of Intravenous Dexketoprofen Trometamol With Tenoxicam
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: dexketoprofen trometamol|DRUG: tenoxicam|DRUG: serum physiologic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Apatinib Monotherapy Versus Apatinib Combined With Camrelizumab for Third-line Treatment of Metastatic Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer|Metastasis
Interventions: DRUG: Apatinib Mesylate|DRUG: Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Amifostine in Treating Patients With Advanced Cancer
Status: UNKNOWN
Conditions: Chronic Myeloproliferative Disorders|Drug/Agent Toxicity by Tissue/Organ|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Precancerous Condition|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: sargramostim|DRUG: amifostine trihydrate|DRUG: carboplatin|DRUG: cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Single-center, Prospective Cohort Study of PD-1 Inhibitors on Clinical Outcomes of Carotid Plaques in Tumor Patients
Status: UNKNOWN
Conditions: Carotid Artery Plaque|Pd-1 Inhibitors
Interventions: DRUG: PD-1 inhibitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial of ASP7487 (OSI-906) in Combination With Bortezomib for the Treatment of Relapsed Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: ASP7487, Velcade, Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Tofacitinib in Adult Subjects With Discoid Lupus Erythematosus (DLE) and Systemic Lupus Erythematosus (SLE)
Status: TERMINATED
Conditions: Discoid Lupus Erythematosus|Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: Tofacitinib citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benefit of Placebo and Different Concentrations of Triamcinolone Acetonide in Nail Psoriasis
Status: COMPLETED
Conditions: Nail Psoriasis|Nail Diseases
Interventions: DRUG: Placebos|DRUG: Triamcinolone Acetonide 2.5 mg/mL|DRUG: Triamcinolone Acetonide 5.0 mg/mL|DRUG: Triamcinolone Acetonide 7.5 mg/mL|DRUG: Triamcinolone Acetonide 10 mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Music Therapy is Associated With Decreased Pain and Agitation in Intubated ICU Patients
Status: TERMINATED
Conditions: Music Therapy for Pain and Sedation
Interventions: OTHER: provide headphones with music playing|OTHER: Sounds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of INCB007839 With Trastuzumab and Vinorelbine in Patients With Metastatic HER2+ Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: INCB007839 300mg BID|DRUG: Trastuzumab|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CARNIVAL Study: Gut Flora Dependent Metabolism of Dietary CARNItine and Phosphatidylcholine and cardioVAscuLar Disease
Status: ENROLLING_BY_INVITATION
Conditions: Dietary Modification
Interventions: DIETARY_SUPPLEMENT: Carnitine|DIETARY_SUPPLEMENT: Choline|DRUG: Antibiotics|DRUG: Choline and Aspirin|DRUG: Carnitine and Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Determination of Biological Activity of Three Allergen Extracts
Status: COMPLETED
Conditions: Hypersensitivity
Interventions: BIOLOGICAL: Skin Prick Test - Atopic subjects|BIOLOGICAL: Skin Prick Test - Non Atopic subjects|BIOLOGICAL: Skin Prick Test - Allergic subjects
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Complete Mesocolic Excision With Central Vessel Ligation Compared With Conventional Surgery for Colon Cancer
Status: UNKNOWN
Conditions: Colon Cancer
Interventions: PROCEDURE: Conventional Surgery|PROCEDURE: Complete mesocolic excision with central vascular ligation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RSA vs. Nonop for 3 & 4-Part Proximal Humerus Fractures
Status: TERMINATED
Conditions: Humerus Fracture|Humerus|Shoulder Fractures|Shoulder Arthropathy Associated With Other Conditions|Arthropathy Shoulder|Shoulder Injury|Arthropathy
Interventions: PROCEDURE: Reverse Total Shoulder Arthroplasty (rTSA)|OTHER: Nonoperative Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study With MIP-1404 in Men With High-Risk PC Scheduled for RP and EPLND Compared to Histopathology
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Drug: 99mTc-MIP-1404
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Functional Exercise and Nutrition Education Program for Older Adults
Status: COMPLETED
Conditions: Chronic Disease|Frail|Diabetes Mellitus|Cancer|Chronic Lung Disease|Cardiovascular Diseases|Congestive Heart Failure|Hypertension|Osteoporosis, Osteopenia|Arthritis|Stroke|Kidney Diseases
Interventions: OTHER: Strength and Balance Training & Nutrition Education|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Early Radiofrequency Turbinate Reduction on Persistent Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: PROCEDURE: Radiofrequency turbinate reduction|DRUG: Pharmacology treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Luspatercept|DRUG: Epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2a Study of Safety and Tolerability of SPN-810 in Children With ADHD and Persistent Serious Conduct Problems
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity|Conduct Disorder
Interventions: DRUG: SPN-810|DRUG: SPN-810|DRUG: SPN-810|DRUG: SPN-810
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Transcutaneous Electrical Nerve Stimulation on People With Knee Osteoarthritis (OA) and or Chronic Pain
Status: UNKNOWN
Conditions: Knee Pain
Interventions: DEVICE: electrical stimulation|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety and Performance of the ARGOS-IO Intraocular Pressure Sensor System in Subjects With Primary Open Angle Glaucoma (POAG)
Status: COMPLETED
Conditions: Primary Open-angle Glaucoma
Interventions: DEVICE: ARGOS-IO Sensor Pressure System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Sofosbuvir Plus Ribavirin in Japanese Adults With Chronic Genotype 2 HCV Infection
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Sofosbuvir|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iressa and Radiotherapy in the Treatment of the Locally Advanced Inoperable Squamous Cell Carcinoma of the Head and Neck
Status: WITHDRAWN
Conditions: Head and Neck Cancer|Carcinoma, Squamous Cell
Interventions: DRUG: Iressa (Gefitinib)|PROCEDURE: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Treatment for Chronic Urticaria
Status: TERMINATED
Conditions: Diet Modification|Chronic Urticaria
Interventions: OTHER: Treatment group (on low histamine diet)|OTHER: Well-balanced diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AIR (Artificial Implant for Medial Meniscus Replacement) Study
Status: TERMINATED
Conditions: Meniscectomy|Osteo Arthritis Knee
Interventions: DEVICE: Trammpolin® meniscus prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Chorionic Gonadotropin Stimulation Effects on Steroidogenesis in Men With Klinefelter Syndrome
Status: COMPLETED
Conditions: Steroidogenesis|Klinefelter Syndrome|Human Chorionic Gonadotropin (hCG) Stimulation
Interventions: DRUG: human chorionic gonadotropin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: To Test the Potential Efficacy of Repeated Intranasal Administration of Ketamine as a Treatment for PTSD
Status: WITHDRAWN
Conditions: PTSD
Interventions: DRUG: Ketamine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Approach and Avoidance Task (AAT) in Alcoholic Inpatients
Status: UNKNOWN
Conditions: Alcohol Dependence
Interventions: BEHAVIORAL: Inhibit AAT|BEHAVIORAL: classical AAT|BEHAVIORAL: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intragastric Balloon With Lifestyle Intervention vs. Lifestyle Intervention in Obese Patients With NASH
Status: WITHDRAWN
Conditions: Obesity|NASH - Nonalcoholic Steatohepatitis|Obesity, Morbid
Interventions: DEVICE: Intragastric balloon|BEHAVIORAL: Lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pacritinib in Combination With Low Dose Decitabine in Intermediate-High Risk Myelofibrosis or Myeloproliferative Neoplasm (MPN)/Myelodysplastic Syndrome (MDS)
Status: WITHDRAWN
Conditions: Chronic Myelomonocytic Leukemia|Juvenile Myelomonocytic Leukemia|Atypical Chronic Myeloid Leukemia|Myeloproliferative Neoplasm|Myelodysplastic Syndromes|Myelofibrosis
Interventions: DRUG: Pacritinib|DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Loading Doses of Intravenous Bondronat (Ibandronate) in Patients With Breast Cancer and Malignant Bone Disease.
Status: COMPLETED
Conditions: Pain; Bone Neoplasms; Neoplasm Metastasis
Interventions: DRUG: ibandronate [Bondronat]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of TT125-802 in Subjects With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Adult Solid Tumor|Adult Disease|Cancer
Interventions: DRUG: TT125-802
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Platelet-Rich Fibrin on Post-extraction Alveolar Ridge Healing/Preservation as a Stand-alone or Adjunct to Particulate Graft
Status: COMPLETED
Conditions: Extraction Socket Healing|Alveolar Ridge Preservation
Interventions: PROCEDURE: Socket grafting with PRF|PROCEDURE: Socket grafting with bone graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Immunogenicity and Safety Study of GSK Biologicals' Herpes Zoster (HZ) Vaccine GSK1437173A When Co-administered With Pneumovax 23™ in Adults Aged 50 Years and Older
Status: COMPLETED
Conditions: Herpes Zoster|Herpes Zoster Vaccine
Interventions: BIOLOGICAL: Herpes Zoster vaccine GSK 1437173A|BIOLOGICAL: Licensed pneumococcal polysaccharide conjugate vaccine (23-valent, adsorbed), Pneumovax 23™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Analgesic Effect of Non Invasive Stimulation : Comparison of rTMS and tDCS Efficacy
Status: COMPLETED
Conditions: Pharmacoresistant Neuropathic Pain
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CorPath™ 200: Robotically-Assisted Percutaneous Coronary Intervention (PCI)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: CorPath 200|DEVICE: CorPath 200
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of IBI306 in Participants With Hypercholesterolemia
Status: UNKNOWN
Conditions: Hypercholesterolemia
Interventions: DRUG: IBI306|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oropharyngeal Exercises and Inspiratory Muscle Training in Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: OTHER: respiratory muscle strengthening exercise|OTHER: oropharyngeal muscles strengthening exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3b Multicenter Study of Pregabalin in Fibromyalgia Subjects Who Have Comorbid Depression
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: Pregabalin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemoprevention of Head and Neck Squamous Cell Carcinoma (HNSCC) With Valproic Acid
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Valproic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Gomco Versus Mogen: Which is Best? A Randomized Controlled Trial
Status: COMPLETED
Conditions: Circumcision, Male
Interventions: DEVICE: Gomco Circumcision Clamp|DEVICE: Mogen Circumcision Clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of LAS 34273 in Patients With Moderate to Severe Stable Chronic Obstructive Pulmonary Disease(COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Aclidinium bromide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing Linear Growth Faltering Among Low Birth Weight Infants in Bangladesh
Status: COMPLETED
Conditions: Infant, Low Birth Weight
Interventions: OTHER: Hand Sanitizer|DIETARY_SUPPLEMENT: Improved Micronutrient Powder|OTHER: No hand sanitizer|DIETARY_SUPPLEMENT: No Micronutrient Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Behavioral Health Interdisciplinary Program - Collaborative Chronic Care Model (BHIP-CCM) Enhancement Project 2.0
Status: ENROLLING_BY_INVITATION
Conditions: Mental Health
Interventions: OTHER: Implementation Facilitation|OTHER: Centralized Technical Assistance
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase I Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Anti-PD-1 Antibody (HLX10) in Combination With Avastin Biosimilar (HLX04) in Patients With Advanced Solid Tumors
Status: UNKNOWN
Conditions: Solid Tumor
Interventions: DRUG: HLX04|DRUG: HLX10
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of KYG0395 on Primary Dysmenorrhea
Status: COMPLETED
Conditions: Primary Dysmenorrhea
Interventions: DRUG: high dose KYG0395|DRUG: lower dose KYG0395|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Posttraumatic Stress Disorder and Aggressive Behavior in Soldiers and Ex-combatants
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder|Aggressive Behavior|Appetitive Aggression
Interventions: BEHAVIORAL: FORNET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation the Post Operative Pain of Endodontic Treated Molar Tooth With Race and Reciprocal Systems Among Bandarabbas Patients in 2017
Status: UNKNOWN
Conditions: Endodontically Treated Teeth
Interventions: PROCEDURE: reciproc|PROCEDURE: race rotary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mitigating Sexual Stigma Within Healthcare Interactions Improve Engagement of MSM in HIV Prevention
Status: ENROLLING_BY_INVITATION
Conditions: Human Immunodeficiency Virus|Stigma, Social|Patient Engagement
Interventions: BEHAVIORAL: A set of implementation strategies to reduce sexual stigma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cardiovascular Effects of Rapidly Declining Plasma Glucose in Patients With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: OTHER: Rapidly declining plasma glucose|OTHER: Slowly declining plasma glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: IntraCranial Atherosclerosis Related Large-vessel Occlusion Treated With Urgent Stenting (ICARUS)
Status: NOT_YET_RECRUITING
Conditions: Stroke|Stroke, Acute Ischemic|Intracranial Atherosclerosis
Interventions: PROCEDURE: Intracranial stenting|PROCEDURE: Continuation of conventional endovascular therapy (EVT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multidisciplinary Combined Exercise and Nutrition Intervention for Sarcopenia
Status: RECRUITING
Conditions: Sarcopenia
Interventions: COMBINATION_PRODUCT: Combined exercise and nutrition intervention|OTHER: Conventional medial care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-Dose Tamoxifen Citrate in Reducing Breast Cancer Risk in Radiation-Induced Cancer Survivors
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Tamoxifen Citrate|DRUG: Placebo|PROCEDURE: Digital mammography|OTHER: immunohistochemistry staining method|OTHER: pharmacological study|OTHER: laboratory biomarker analysis|GENETIC: protein expression analysis|OTHER: pharmacogenomic studies|OTHER: questionnaire administration|PROCEDURE: Fine needle aspiration|OTHER: Quality of Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study in Healthy People to Test Whether Different Doses of BI 1015550 Have Potential to Induce Heart Rhythm Abnormalities
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1015550|DRUG: Moxifloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Simvastatin-ezetimibe Combination Therapy Among Patients With SLE
Status: UNKNOWN
Conditions: Atherosclerosis
Interventions: DRUG: Ezetimibe+Simvastatin Drug Combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Determine the Effect of Sumatriptan and Naproxen Sodium Combination Tablet, Sumatriptan Tablet, and Naproxen Sodium Tablet on Blood Pressure When Treating Migraine Headaches That Occur During a 6-month Period
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: DRUG: sumatriptan and naproxen sodium combination tablet|DRUG: sumatriptan tablet|DRUG: naproxen sodium tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FT538 in Subjects With Advanced Hematologic Malignancies
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|AML, Adult|Multiple Myeloma|Myeloma
Interventions: DRUG: FT538|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Daratumumab|DRUG: Elotuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase Ib Study to Assess Safety and Preliminary Efficacy of Tafasitamab or Tafasitamab Plus Lenalidomide in Addition to R-CHOP in Patients With Newly Diagnosed DLBCL
Status: COMPLETED
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: Tafasitamab|DRUG: Tafasitamab plus lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relationship Apical Periodontitis and the Main Bacterial Species in the Oral Microbiota
Status: COMPLETED
Conditions: Periapical Periodontitis|MMP-9
Interventions: OTHER: apical periodontitis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Auto Fecal Microbial Transplant Post Helicobacter Pylori Antibiotic Therapy
Status: RECRUITING
Conditions: Helicobacter Pylori Infection
Interventions: BIOLOGICAL: Fecal Microbial Transplant (FMT)|OTHER: Placebo capsules|BIOLOGICAL: Auto Fecal Microbial Transplant (FMT) via enema
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study on the Influence of Fluoroscopy in the Diagnosis of Peripheral Lung Lesions With Endobronchial Ultrasound Guidance
Status: COMPLETED
Conditions: Peripheral Pulmonary Lesions
Interventions: PROCEDURE: Fluoroscopy|PROCEDURE: Radial EBUS-guided biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: AMPLE-3: IPC Plus Talc vs VATS in Management of Malignant Pleural Effusion
Status: RECRUITING
Conditions: Malignant Pleural Effusion|Respiratory Disease|Cancer
Interventions: PROCEDURE: Pleurodesis via Video-assisted thoracoscopic surgery|DEVICE: Indwelling pleural catheter (with talc pleurodesis if suitable)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Endothelial Progenitor Cell Therapy for Reversal of Liver Cirrhosis
Status: UNKNOWN
Conditions: End Stage Liver Disease
Interventions: DRUG: GCSF|PROCEDURE: CD133 Cells Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of MAP0004 in Adult Migraineurs
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: DRUG: MAP0004|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Assess the Efficacy and Safety of RVT-1401 in the Treatment of Warm Autoimmune Hemolytic Anemia (ASCEND-WAIHA).
Status: TERMINATED
Conditions: Warm Autoimmune Hemolytic Anemia
Interventions: DRUG: RVT-1401 680 mg/weekly|DRUG: RVT-1401 340 mg/weekly
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Two Strains of BCG
Status: COMPLETED
Conditions: Morbidity|Bacille Calmette-Guérin
Interventions: BIOLOGICAL: BCG-Denmark 1331 (Statens Serum Institute)|BIOLOGICAL: BCG-Russia-I (Serum Institute of India)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of VTI Doppler Probe Use to Identify Neurovascular Bundle During Prostate Surgery
Status: TERMINATED
Conditions: Prostate Cancer|Nerve Sparing Prostatectomy
Interventions: DEVICE: VTI Probe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Acute Effects of R- and S-MDMA in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 3,4-methylenedioxymethamphetamine|DRUG: S-3,4-methylenedioxymethamphetamine|DRUG: R-3,4-methylenedioxymethamphetamine (125 mg)|DRUG: R-3,4-methylenedioxymethamphetamine (250 mg)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pulmicort Respules on Relapse Rates After Treatment in the ED
Status: WITHDRAWN
Conditions: Asthma
Interventions: DRUG: pulmicort respules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Arotinolol Hydrochloride on Cardiovascular Events in Hypertensive Haemodialysis Patients
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Arotinolol Hydrochloride|DRUG: Non arotinolol group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-Dose 131I-MIBG Therapy Combined With Vincristine and Five Days of Irinotecan for Resistant/Relapsed Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: DRUG: Metaiodobenzylguanidine (MIBG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Oral Ingestion of Drinking Water Using a Tumbler That Emits Far Infrared Rays on Metabolic Profile
Status: COMPLETED
Conditions: Metabolic Problems
Interventions: DIETARY_SUPPLEMENT: infrared water group|DIETARY_SUPPLEMENT: sham group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Addressing Post-COVID-19 Musculoskeletal Symptoms
Status: RECRUITING
Conditions: Telemedicine|Musculoskeletal Disease|SARS-CoV-2|Pain|COVID-19|Exercise
Interventions: OTHER: Multicomponent exercise program|OTHER: Tele-health primary care rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of a Non-invasive Brain Monitor
Status: UNKNOWN
Conditions: Brain Injuries|Subarachnoid Hemorrhage|Vasospasm, Intracranial|Hydrocephalus|Brain Neoplasms
Interventions: DEVICE: HS-1000 recording
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluating the Renoprotective Effect of Milk Thistle Extract on Patients With Type II Diabetic Nephropathy
Status: COMPLETED
Conditions: Diabetic Nephropathy
Interventions: DRUG: placebo|DRUG: Milk Thistle extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Infrapatellar Fat Pad Excision in Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Knee Discomfort|Arthroplasty Complications
Interventions: PROCEDURE: Removal of infrapatellar fat pad|PROCEDURE: No removal of infrapatellar fat pad
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-Guided Diaphragmatic Thickness Assessment as an Indicator of Successful Extubation in Mechanically Ventilated
Status: COMPLETED
Conditions: Successful Weaning|Weaning Failure
Interventions: COMBINATION_PRODUCT: Ultrasound assessment of diaphragm thickness in B-mode
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Edge AI-deployed DIGItal Twins for PREDICTing Disease Progression and Need for Early Intervention in Infectious and Cardiovascular Diseases Beyond COVID-19 - Investigation of Biomarkers in Dermal Interstitial Fluid
Status: NOT_YET_RECRUITING
Conditions: Heart Failure
Interventions: DEVICE: Use of the PELSA System for dISF extraction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dimensional Changes of Peri-implant Tissue in Immediate Implants With Individualized Healing Abutments
Status: RECRUITING
Conditions: Dental Implant|Immediate Dental Implant|Wound Heal
Interventions: DEVICE: Standard healing abutment|DEVICE: Individualized healing abutment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Olmesartan Associated With Chlorthalidone Versus Benicar HCT® in Essential Hypertension Control
Status: NOT_YET_RECRUITING
Conditions: Arterial Hypertension
Interventions: DRUG: Olmesartan medoxomil 40mg + chlorthalidone 12,5mg|DRUG: Olmesartan medoxomil 40mg + chlorthalidone 25mg|DRUG: Olmesartan 40mg + Hydrochlorothiazide 12,5mg|DRUG: Olmesartan 40mg + Hydrochlorothiazide 25mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telbivudine Versus Lamivudine in Adults With Decompensated Chronic Hepatitis B and Evidence of Cirrhosis
Status: COMPLETED
Conditions: Hepatitis|Hepatitis B, Chronic|Cirrhosis
Interventions: DRUG: Telbivudine|DRUG: Lamivudine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Cingal for the Relief of Knee Osteoarthritis Compared to Triamcinolone Hexacetonide at 39 Weeks Follow up
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: COMBINATION_PRODUCT: Cingal|DEVICE: Monovisc|DRUG: Triamcinolone Hexacetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy of COVID19-0001-USR in Patients With Mild/or Moderate COVID-19 Infection in Outpatient
Status: UNKNOWN
Conditions: SARS-CoV-2 Infection
Interventions: DRUG: Drug COVID19-0001-USR|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: treadmill training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diabetic Neuropathy Screening Study 1.1 + Substudy 1.2-1.3-1.4
Status: UNKNOWN
Conditions: Diabetic Neuropathies|Distal Peripheral Sensory Neuropathy|Diabetic Foot|Foot Deformities|Autonomic Neuropathy|CAN
Interventions: DEVICE: Vagus|DEVICE: HeartsTrends|DEVICE: Sudoscan|DEVICE: UllMeter|DEVICE: DPN-check|DEVICE: Rolltemp|DEVICE: Dexcom G6 Device
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prognostic Value of The Age, Creatinine, and Ejection Fraction Score for Non-infarct-related Chronic Total Occlusion Revascularization After Primary Percutaneous Intervention in Acute ST-elevation Myocardial Infarction Patients: A Retrospective Study
Status: COMPLETED
Conditions: Cto, Acef Score
Interventions: PROCEDURE: ACEF score
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma
Status: RECRUITING
Conditions: Rectal Cancer
Interventions: BIOLOGICAL: Envafolimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opiate Sparing Protocol Randomized Controlled Trial in Open Distal Radius Fracture Repair
Status: ENROLLING_BY_INVITATION
Conditions: Distal Radius Fracture
Interventions: OTHER: Opiate Sparing|OTHER: Opiate Based
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Scandinavian Humeral Diaphyseal Fracture Trial
Status: RECRUITING
Conditions: Fracture Humerus of Shaft
Interventions: PROCEDURE: Surgical treatment|DEVICE: Non-surgical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Long-Term Safety of Topical Administration of FMX103 in the Treatment of Moderate to Severe Papulopustular Rosacea
Status: COMPLETED
Conditions: Papulopustular Rosacea
Interventions: DRUG: FMX103 1.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Cilostazol Versus Cilostazol and Selenium Combination on the Healing of Diabetic Foot Ulcer Patients
Status: RECRUITING
Conditions: Wound Heal
Interventions: DRUG: Cilostazol|DRUG: Selenium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SAFEGUARD: Pleiotropic Effects of Incretin Based Therapies
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Liraglutide|DRUG: Sitagliptin|DRUG: Exenatide|DRUG: Liraglutide placebo|DRUG: Sitagliptin placebo|DRUG: Exenatide placebo|DRUG: L-NMMA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between McGrath and Macintosh Laryngoscopes for DLT Intubation in Thoracic Surgery Patients.
Status: RECRUITING
Conditions: Thoracic Diseases|Thoracic Neoplasms|Thoracic Empyema
Interventions: DEVICE: MaCintosh Laryngoscope (DL)|DEVICE: McGrath Laryngoscope (VL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study to Assess Therapeutic Equivalence Between Test EMLA Patch With Marketed EMLA Patch in Healthy Subjects.
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: EMLA test patch|DRUG: EMLA current reference patch|DRUG: Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Safety and Effectiveness of Clarithromycin in the Prevention of Mycobacterium Avium Complex (MAC) Infection in HIV-Infected Patients
Status: COMPLETED
Conditions: Mycobacterium Avium-intracellular Infection|HIV Infections
Interventions: DRUG: Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: O(6)-Benzylguanine and Temozolomide in Treating Patients With Glioblastoma Multiforme That Did Not Respond to Previous Temozolomide and Radiation Therapy
Status: TERMINATED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: O6-benzylguanine|DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetocardiography as a Non-Invasive Tool for Detecting Tissue Rejection in Heart Transplant Patients
Status: COMPLETED
Conditions: Heart Transplantation
Interventions: DEVICE: Magnetocardiograph
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mycophenolate Mofetil in Combination With Standard of Care for the Treatment of Glioblastoma
Status: RECRUITING
Conditions: Astrocytoma|Glioblastoma|Glioblastoma, IDH-Wildtype|MGMT-Unmethylated Glioblastoma|Recurrent Glioblastoma
Interventions: DRUG: Mycophenolate Mofetil|OTHER: Quality-of-Life Assessment|RADIATION: Radiation Therapy|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label, Single-centre Study Evaluating the Pharmacokinetics of Digoxin Alone and When Administered at Various Doses of Ezogabine/Retigabine in Healthy Adults. The Pharmacokinetics of Ezogabine/Retigabine and the N-acetyl Metabolite of Ezogabine/Retigabine (NAMR) Will Also be Assessed
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Digoxin Alone|DRUG: Digoxin + Retigabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Iadademstat in Combination With Paclitaxel in Relapsed/Refractory SCLC and Extrapulmonary High Grade NET
Status: RECRUITING
Conditions: Small-cell Lung Cancer|Neuroendocrine Carcinoma
Interventions: DRUG: Iadademstat|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Non-CE Marked Intermittent Catheters.
Status: COMPLETED
Conditions: Retention, Urinary
Interventions: DEVICE: SpeediCath® Standard male|DEVICE: New intermittent Variant 1 catheter for males|DEVICE: New intermittent Variant 2 catheter for males
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SF2a-TT15 Conjugate Vaccine in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Shigellosis|Bacillary Dysentery
Interventions: BIOLOGICAL: SF2a-TT15 vaccine|BIOLOGICAL: SF2a-TT15 vaccine + adjuvant|BIOLOGICAL: Placebo|BIOLOGICAL: Placebo + adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Comparing Acular LS and Pred Forte in Reducing Post-selective Laser Trabeculoplasty Anterior Chamber Flare and Cells
Status: TERMINATED
Conditions: Open Angle Glaucoma
Interventions: DRUG: Acular LS|DRUG: Pred Forte|OTHER: Refresh Tears
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GUIDed Growth of the Proximal Femur to Prevent Further Hip migrAtion iN CErebral Palsy Patients
Status: NOT_YET_RECRUITING
Conditions: Cerebral Palsy|Hip Dislocation
Interventions: PROCEDURE: Temporary Medial Hemi-epiphysiodesis of the proximal femur
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effect of Air Heat Versus Infra Red Heat on Pain and Wound Healling After Vaginal Delivery Episiotomy
Status: RECRUITING
Conditions: Episiotomy Wound
Interventions: PROCEDURE: Infra-red lamp therapy + Kegal Exercises|PROCEDURE: Dry air heat group + Kegal Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AngioDefender Versus Brachial Artery Ultrasound Imaging
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DEVICE: AngioDefender|DEVICE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: rTMS for Depression in Young Adults With Autism
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Major Depressive Disorder
Interventions: DEVICE: Active Bilateral Theta Burst Stimulation|DEVICE: Sham Bilateral Theta Burst Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Ingestion of Dentifrice by Children
Status: COMPLETED
Conditions: Healthy Individuals
Interventions: DRUG: Marketed Dentifrice|DRUG: Marketed Flavored Dentifrice|DRUG: Marketed Flavored Dentifrice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: