pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase II Study of Stereotactic Body Radiation Therapy Using Tomotherapy for Tumors of the Lung
Status: COMPLETED
Conditions: Lung Cancer|Non Small Cell Lung Cancer|Solid Tumors
Interventions: RADIATION: Stereotactic Body Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of NN5401 With Biphasic Insulin Aspart 30 in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec/insulin aspart|DRUG: biphasic insulin aspart 30
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parental Presence During Fracture Reduction in Children at the Emergency Department; A Randomized Controlled Trial
Status: TERMINATED
Conditions: Conscious Sedation|Anxiety
Interventions: BEHAVIORAL: Parental presence|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Aromatherapy to Women With Vasomotor Complaints on Menopausal Quality of Life and Vasomotor Symptoms
Status: RECRUITING
Conditions: Aromatherapy
Interventions: OTHER: placebo group|OTHER: mint oil group|OTHER: rose oil group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Pregabalin Gel in Controlling Cervical Dentin Hypersensitivity
Status: NOT_YET_RECRUITING
Conditions: Dentin Sensitivity
Interventions: OTHER: Placebo Treatment|OTHER: Nitrate Potassium Treatment|OTHER: Pregabalin Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Rapid Aflibercept and Brolucizumab T&E in wAMD
Status: ENROLLING_BY_INVITATION
Conditions: Wet Age-related Macular Degeneration
Interventions: DRUG: Aflibercept|DRUG: Brolucizumab|PROCEDURE: early treat and extend (T&E)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic, Safety, and Pharmacodynamic Study of Teduglutide in Pediatric Subjects With Short Bowel Syndrome
Status: COMPLETED
Conditions: Short Bowel Syndrome
Interventions: DRUG: teduglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Long Term Safety and Efficacy of DWP16001 in Patients With Type 2 Diabetes Mellitus
Status: NOT_YET_RECRUITING
Conditions: T2DM (Type 2 Diabetes Mellitus)
Interventions: DRUG: DWP16001 0.3 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Qudratus Lumborum Block Versus Unilateral Intrathecal Block for Inguinal Hernia Repair
Status: UNKNOWN
Conditions: Inguinal Hernia,Quadratus Lumborum Block , Unilateral Intrathecal Block
Interventions: PROCEDURE: unilateral intrathecal block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Topical Anesthesia and Analgosedation in Micropulse Transscleral Glaucoma Treatment
Status: COMPLETED
Conditions: Glaucoma
Interventions: DEVICE: Micropulse Transscleral Laser Therapy for Glaucoma (MP-TLT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Virtual Reality Combined With Cycloergometer Versus Conventional Cycloergometer on Distance Covered for Intensive Care Unit Non-sedated Participants
Status: RECRUITING
Conditions: Intensive Care Unit
Interventions: DEVICE: Virtual reality and Cycloergometer|OTHER: Standard cycloergometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing Parathyroid Glands Vascularisation by ICG Fluoroscopy
Status: COMPLETED
Conditions: Parathyroid Function Low Adverse Event
Interventions: PROCEDURE: Postoperative parathyroid function test|PROCEDURE: No postoperative parathyroid dosage and supplementation|PROCEDURE: ICG parathyroid angiography|DRUG: Parathyroid supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: High Intensity Laser Versus Ischemic Compression on Myofascial Trigger Points in the Upper Trapezius
Status: ACTIVE_NOT_RECRUITING
Conditions: Neck Pain
Interventions: DEVICE: TENs , ultrasound therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of a Cognitive and Physical Intervention to Reduce Head and Muscle Pain in a Working Community
Status: COMPLETED
Conditions: Migraine|Tension Type Headache|Cervical Pain
Interventions: BEHAVIORAL: Cognitive, Relaxation, Exercise Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing NAVA Levels in Intubated and Recently Extubated Neonates to Determine Optimal Non-invasive Ventilatory Support
Status: COMPLETED
Conditions: Other Specified Respiratory Problems in Fetus or Neonate
Interventions: PROCEDURE: NAVA level|OTHER: NAVA level
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: REMEMBER: Reducing Early Mortality & Morbidity by Empiric Tuberculosis (TB) Treatment
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: Atripla (r)|DRUG: Efavirenz|DRUG: Truvada|DRUG: Rifampin/isoniazid/pyrazinamide/ethambutol FDC|DRUG: Rifampin/isoniazid FDC|DRUG: Isoniazid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Fibrin Sealant Grifols (FS Grifols) During Parenchymous Tissue Open Surgeries
Status: COMPLETED
Conditions: Parenchymous Tissue Surgical Bleeding
Interventions: BIOLOGICAL: Fibrin Sealant Grifols|DEVICE: Surgicel®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Vitamin K2 Supplementation and Arterial Stiffness in the Renal Transplant Population (The KING Trial)
Status: COMPLETED
Conditions: Arterial Stiffness|Vitamin K2 Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin K2 (MK7)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effect of the Wireless Micro Current Stimulation in Pediatric Deep Dermal Burns and Scald Injuries
Status: UNKNOWN
Conditions: Burns
Interventions: DEVICE: First investigational device|DEVICE: Second investigational device|DEVICE: ES Wetling W200 Placebo with white light|DEVICE: ES Wetling W200 Placebo with red light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Procalcitonin (PCT)-Guided Antibiotic Use in Severe Sepsis Patients Without Obvious Infection
Status: TERMINATED
Conditions: Severe Sepsis
Interventions: OTHER: Procalcitonin level
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Selinexor in Treating Younger Patients With Recurrent or Refractory Solid Tumors or High-Grade Gliomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Glioma|Recurrent Brain Neoplasm|Recurrent Childhood Central Nervous System Neoplasm|Recurrent Childhood Glioblastoma|Recurrent Lymphoma|Recurrent Malignant Solid Neoplasm|Refractory Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Primary Central Nervous System Neoplasm|WHO Grade 3 Glioma
Interventions: OTHER: Pharmacological Study|DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multifactorial Falls Prevention Program - Brazil
Status: COMPLETED
Conditions: Accidental Falls
Interventions: OTHER: On-site exercise|OTHER: home-based exercise|OTHER: Educational and behavioural|OTHER: Management of modifiable risk factors|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Iron Supplementation in Hip/Knee Surgery
Status: COMPLETED
Conditions: Orthopedic Disorder|Hip Arthropathy|Knee Arthropathy|Anemia|Iron Poor Blood
Interventions: DIETARY_SUPPLEMENT: Sucrosomial iron plus ascorbic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Secondary Infusion of Relma-cel Injection for Relapsed or Refractory B-cell Lymphoma
Status: RECRUITING
Conditions: Relapsed or Refractory B-cell Lymphoma
Interventions: DRUG: Relmacabtagene Autoleucel Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diabetic Macular Edema Asian Response (DEAR) Study: Biomarkers for Response to Aflibercept in Asian Patients With Center Involving DME
Status: UNKNOWN
Conditions: Diabetic Macular Edema
Interventions: DRUG: Aflibercept Injection [Eylea]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study of How NNC0174-0833 Taken With Semaglutide Works in People Who Are Overweight or Obese
Status: COMPLETED
Conditions: Obesity|Overweight
Interventions: DRUG: NNC0174-0833|DRUG: Semaglutide|DRUG: Placebo (NNC0174-0833)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Project MADD - NIH Underage DUI and Ride
Status: COMPLETED
Conditions: Underage Drinking|Driving Under the Influence|Drinking, Teen
Interventions: BEHAVIORAL: MADD Materials|BEHAVIORAL: Surgeon General Materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Safety and Efficacy of CJ-30061 in Hypertensive Patients With Hyperlipidemia
Status: UNKNOWN
Conditions: Hypertension|Hyperlipidemia
Interventions: DRUG: Amlodipine 10mg+Valsartan 160mg+Atorvastatin 40mg|DRUG: Amlodipine 10mg+Valsartan 160mg|DRUG: Valsartan 160mg+Atorvastatin 40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of "EmoGuía" to Guide and Personalize Psychological Treatments
Status: NOT_YET_RECRUITING
Conditions: Emotional Disorder
Interventions: DEVICE: My EMI, Emotional Well-being + self-applied online transdiagnostic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: CMOEP in the Treatment of Untreated Peripheral T-cell Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Peripheral T-cell Lymphoma
Interventions: DRUG: Lposomal mitoxantrone hydrochloride,Cyclophosphamide,Vincristine,Etoposide and Prednisone(CMOEP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cavotricuspid Isthmusblock and Circumferential Pulmonary Vein Isolation in Patients With Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Pulmonary vein isolation and cavotricuspid ishtmusblock
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Gene Therapy for the Treatment of Leber Congenital Amaurosis (LCA)
Status: COMPLETED
Conditions: Leber Congenital Amaurosis
Interventions: BIOLOGICAL: AAV RPE65
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inspiratory Muscle Training on Diaphragm Thickness, Inspiratory Muscle Strength and Shoulder Pain in Tennis Player
Status: RECRUITING
Conditions: Shoulder Pain|Inspiratory Muscle Training
Interventions: OTHER: inspiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Alcohol on Common Tremor Syndromes
Status: NOT_YET_RECRUITING
Conditions: Essential Tremor|Dystonia|Parkinson Disease
Interventions: DIETARY_SUPPLEMENT: Alcoholic drink|DIETARY_SUPPLEMENT: Placebo drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 1b/2 Study of Serabelisib in Combination With Canagliflozin in Patients With Advanced Solid Tumors
Status: UNKNOWN
Conditions: Breast Cancer|Endometrial Cancer|Lung Cancer|Colo-rectal Cancer|Head and Neck Cancer
Interventions: DRUG: Serabelisib|DRUG: Canagliflozin 300mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Benefit of Midodrine in the Treatment of Patients With Neurogenic Orthostatic Hypotension
Status: COMPLETED
Conditions: Hypotension, Orthostatic
Interventions: DRUG: Midodrine hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 2-Year Prospective Follow-up Study of the Global Unite Reverse Fracture Shoulder System for Proximal Humerus Fractures
Status: UNKNOWN
Conditions: Shoulder Fractures
Interventions: DEVICE: Reverse Total Shoulder Arthroplasty|DEVICE: Hemiarthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing The Effect On Disease Activity When Reducing Or Discontinuing Etanercept In Subjects With RA
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Etanercept|DRUG: Etanercept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: POstopeRative Standardization of Care: THe Implementation of Best Practice After Pancreatic Resection
Status: UNKNOWN
Conditions: Pancreatic Diseases|Pancreatic Neoplasms|Pancreatic Cancer|Pancreatitis
Interventions: OTHER: Best practice algorithm for postoperative care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Distraction Methods on Pain Perceptions and Anxiety Levels in Children During the Blood Collection
Status: COMPLETED
Conditions: Acute Pain|Nursing Caries
Interventions: OTHER: music group|OTHER: kaleidoscope group|OTHER: video group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Early Pharmaceutical Intervention for Cardiovascular Disease Prevention in Stage 1 Hypertension
Status: NOT_YET_RECRUITING
Conditions: Cardiovascular Diseases
Interventions: DRUG: RASI and/or a single pill combination based RASI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Adjuvant Effect of Photobiomodulation in the Treatment of Incontinence-associated Dermatitis in Adults
Status: WITHDRAWN
Conditions: Incontinence Associated Dermatitis|Diaper Rash|Photobiomodulation Therapy
Interventions: OTHER: protective spray film|DEVICE: photobiomodulation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Differential Effects of Inhaled Symbicort and Advair on Lung Microbiota
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Fluticasone group|DRUG: Budesonide group|DRUG: Formoterol group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Bosutinib Pediatric Capsule Relative to Commercial Tablet Under Fed Condition
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Bosutinib capsule|DRUG: Bosutinib tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Prospective, Open-label, Multicenter, Randomized Controlled Phase III Study of Prophylactic Central Neck Dissection in Low-risk Papillary Thyroid Cancer
Status: RECRUITING
Conditions: Thyroid Cancer|Recurrence
Interventions: PROCEDURE: prophylactic central neck dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pregabalin vs. Gabapentin on Reducing Opioid Usage
Status: RECRUITING
Conditions: Analgesics|Gabapentin|Injuries|Narcotics|Pain|Trauma
Interventions: DRUG: Pregabalin 50mg|DRUG: Gabapentin 300mg|DRUG: Neither Pregabalin nor Gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Evaluation of Crohn's Disease
Status: TERMINATED
Conditions: Crohn Disease
Interventions: DRUG: Sulfur Hexafluoride|DEVICE: Ultrasound Elastography|DEVICE: Ultrasound Vascularity|DEVICE: Magnetic Resonance Enterography (MRE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dynamic Full-Field Optical Coherence Tomography for Structural and Microbiological Characterization of Central Venous Catheter-deposited Biofilm in Critically Ill Patients
Status: RECRUITING
Conditions: Healthcare Associated Infection|Critically Ill|Central Venous Catheter Associated Bloodstream Infection
Interventions: OTHER: D-FF-OCT analysis of CVC
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Effectiveness and Safety of Ustekinumab (STELARA) and CNTO 1959 Administered Under the Skin of Patients With Active Rheumatoid Arthritis, Despite Existing Methotrexate Therapy
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Placebo + methotrexate (MTX) (Group 1)|DRUG: Ustekinumab + MTX (Group 2)|DRUG: Ustekinumab + MTX (Group 3)|DRUG: CNTO 1959 + MTX (Group 4)|DRUG: CNTO 1959 + MTX (Group 5)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Totally Laparoscopic Distal Gastrectomy for Gastric Cancer
Status: RECRUITING
Conditions: Postoperative Complications
Interventions: PROCEDURE: totally laparoscopic distal gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glytactin EfficiEncy in Non or Insufficiently Treated Adult PHENylketonuria Patients
Status: COMPLETED
Conditions: Adult Phenylketonuria Non Treated Patients
Interventions: DIETARY_SUPPLEMENT: Dietary Supplement for PKU patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Cerebral Oxygen Saturation Monitoring on POCD of Elderly Patients Undergoing Shoulder Arthroscopy
Status: NOT_YET_RECRUITING
Conditions: Cerebral Oxygen Saturation|Postoperative Cognitive Function
Interventions: OTHER: Controlled hypotension guided by cerebral oxygen saturation monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy Study of Triamcinolone Associated With Nepafenac for Treatment of Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Triamcinolone + Nepafenac|DRUG: triamcinolone intravitreal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Embryo Transfer Catheters in Patients Undergoing in Vitro Fertilization and Embryo Transfer
Status: TERMINATED
Conditions: Infertility
Interventions: DEVICE: Protective catheter group|DEVICE: Conventional catheter group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The HIV, Adipose Tissue Immunology, and Metabolism Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Hiv|Diabetes Mellitus, Type 2
Interventions: PROCEDURE: Subcutaneous adipose tissue biopsy|RADIATION: CT scan|DIAGNOSTIC_TEST: Oral glucose tolerance test|DIAGNOSTIC_TEST: Blood collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Acetazolamide and Methazolamide on Hypoxic Exercise Performance
Status: COMPLETED
Conditions: High Altitude Effects
Interventions: DRUG: Acetazolamide 250Mg Tab|DRUG: Methazolamide Pill|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Randomized Controlled Trial to Demonstrate the Safety and Efficacy of the OptiVein IV Catheter In a Pediatric Population
Status: TERMINATED
Conditions: Peripheral Venous Catheterization
Interventions: DEVICE: Placement of IV catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Statin and Atheroma Vulnerability Evaluation
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Rosuvastatin calcium 40mg|DRUG: Rosuvastatin calcium10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coronary Artery Disease and Coronary Microvascular Disease in Cardiomyopathies Registry
Status: RECRUITING
Conditions: Hypertrophic|Ischemic|Restrictive Cardiomyopathy|Dilated Cardiomyopathies
Interventions: OTHER: Patients with a cardiomyopathy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Long-term Study, Comparing Vest Therapy to Positive Expiratory Pressure (PEP) Therapy in the Treatment of Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: OTHER: Positive Expiratory Pressure (PEP)|OTHER: High Frequency Chest Wall Oscillation (HFCWO) using InCourage Vest System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Rufinamide Given as an add-on Therapy to Treat Patients With Seizures
Status: WITHDRAWN
Conditions: Refractory Partial Seizures
Interventions: DRUG: Rufinamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypnosis Versus General Anesthesia in Pediatric Surgery: Clinical and Medico-economic Interests
Status: COMPLETED
Conditions: Minimally Invasive Surgery
Interventions: OTHER: Local anesthetic + Hypnosis|DRUG: General anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TAP Catheters Versus Intrathecal Morphine for Cesarean Section
Status: UNKNOWN
Conditions: Abdominal Muscles/Ultrasonography|Adult|Anesthetics, Local/Administration & Dosage|Ropivacaine/Administration & Dosage|Ropivacaine/Analogs & Derivatives|Cesarean Section|Humans|Nerve Block/Methods|Pain Measurement/Methods|Pain, Postoperative/Prevention & Control|Ultrasonography, Interventional
Interventions: DEVICE: TAP catheter|DRUG: intrathecal morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TEAS-induced Analgesia: Dual vs Single Acupoints
Status: COMPLETED
Conditions: Postoperative|Acute Pain|Chronic Pain
Interventions: OTHER: transcutaneous electric acupoint stimulation|OTHER: electrode attached but no stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pituitary Dysfunction After Aneurysmal Subarachnoid Hemorrhage
Status: UNKNOWN
Conditions: Thyroid Disfunction|Subarachnoid Haemorrhage From Cerebral Aneurism Rupture|Pituitary Disfunction
Interventions: BIOLOGICAL: Evaluation of pituitary endocrine function|BEHAVIORAL: Evaluation of clinical outcome|BEHAVIORAL: Evaluation of neuropsychological function
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of Early Enteral Nutrition on Endoscopic Therapy of Esophagogastric Varices in Liver Cirrhosis
Status: COMPLETED
Conditions: Liver Cirrhosis|Esophageal and Gastric Varices
Interventions: DIETARY_SUPPLEMENT: nutrient solution
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Multiple-Dose Study of MK-1006 (MK-1006-004)(TERMINATED)
Status: TERMINATED
Conditions: Type 2 Diabetes
Interventions: DRUG: MK-1006|DRUG: Comparator: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Safety Study of API 31510 in a Topical Cream for in Situ Cutaneous Squamous Cell Carcinoma (SCCIS)
Status: COMPLETED
Conditions: Squamous Cell Carcinoma
Interventions: DRUG: API 31510
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dual Lead Thalamic Deep Brain Recording (DBR)-DBS Interface for Closed Loop Control of Severe Essential Tremor
Status: RECRUITING
Conditions: Essential Tremor
Interventions: DEVICE: Medtronic Summit Rechargable (RC)+S|PROCEDURE: ipsilateral thalamic (VIM+VO) DBS|PROCEDURE: standard ET DBS|PROCEDURE: ipsilateral VO
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Different Cycles of High-dose Dexamethasone for Initial Management of Primary Immune Thrombocytopenia (ITP)
Status: WITHDRAWN
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Dexamethasone (4 cycles)|DRUG: Dexamethasone (1 cycle)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DORA: A Doravirine-based First-line Antiretroviral Therapy for Women of Reproductive Potential Living With HIV
Status: COMPLETED
Conditions: HIV-1-infection
Interventions: DRUG: Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venetoclax and Romidepsin in Treating Patients With Recurrent or Refractory Mature T-Cell Lymphoma
Status: COMPLETED
Conditions: Anaplastic Large Cell Lymphoma|Recurrent Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma|Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Romidepsin|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Extension of EDG-5506 in Participants With Becker Muscular Dystrophy
Status: ENROLLING_BY_INVITATION
Conditions: Becker Muscular Dystrophy
Interventions: DRUG: Sevasemten
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of a Daily Wear Frequent Replacement Silicone Hydrogel Lens
Status: COMPLETED
Conditions: Refractive Errors
Interventions: DEVICE: LID015385 contact lenses|DEVICE: Comfilcon A soft contact lenses|DEVICE: CLEAR CARE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Antipodal Capsular Fold and Its Potential Role in Antero-inferior Glenohumeral Instability
Status: UNKNOWN
Conditions: Shoulder Capsulitis
Interventions: PROCEDURE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of the Dry Needling Approach in Patients With Tension-Type Headache
Status: COMPLETED
Conditions: Tension-Type Headache|Dry Needling
Interventions: OTHER: Dry Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RCT Comparing 19Ga vs 22Ga EBUS-TBNA Needles in Carcinoma.
Status: UNKNOWN
Conditions: Lung Neoplasm
Interventions: DEVICE: EBUS-TBNA needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Single Center, Open-Label Study to Quantify Metabolites of [14C]-Neramexane in Plasma and Urine in Healthy Male Subjects
Status: COMPLETED
Conditions: Metabolism of Neramexane
Interventions: DRUG: Neramexane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Study to Evaluate the Possible Efficacy and Safety of Levocetirizine in Patients With Diabetic Kidney Disease
Status: RECRUITING
Conditions: Diabetic Nephropathies
Interventions: DRUG: Valsartan 80 mg|DRUG: Empagliflozin 10 MG|DRUG: Levocetirizine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of End-Expiratory Lung Volume and Pulmonary Mechanics With Different PEEP Levels in Mechanical Ventilation in ARDS Patients
Status: COMPLETED
Conditions: Ards
Interventions: OTHER: No drugs or biologial agents were used in our trial
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial of Neoadjuvant Weekly Paclitaxel Versus Weekly Paclitaxel Plus Weekly Carboplatin In Women With Large Operable or Locally Advanced, Triple Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Paclitaxel + Carboplatin|DRUG: Paclitaxel only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TPExtreme Induced Chemotherapy Followed by Surgery and Radiotherapy in the Oral Carcinoma.
Status: RECRUITING
Conditions: Oral Squamous Cell Carcinoma|Locally Advanced Head and Neck Squamous Cell Carcinoma
Interventions: PROCEDURE: Modified radical surgery|PROCEDURE: Radical surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Building Capacity and Promoting Smoking Cessation in the Community Via "Quit to Win" Contest 2016
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: HAR|BEHAVIORAL: LTM|BEHAVIORAL: AWARD|OTHER: Referral card|OTHER: A4 leaflet|BEHAVIORAL: Brief advice|OTHER: 12-page booklet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Adolescent Smoking Cessation in Pediatric Primary Care
Status: COMPLETED
Conditions: Tobacco Cessation|Media Use
Interventions: OTHER: 5A's Model|OTHER: Media Use Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: REal-time Data Monitoring for Shared Adaptive, Multi-domain and Personalised Prediction and Decision Making for Long-term Pulmonary Care Ecosystems (RE-SAMPLE)
Status: RECRUITING
Conditions: Pulmonary Disease, Chronic Obstructive|Exacerbation Copd|Comorbidities and Coexisting Conditions
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prophylactic Tranexamic Acid Use After Vaginal Delivery
Status: COMPLETED
Conditions: Postpartum Hemorrhage|Vaginal Delivery|Prophylactic Tranexamic Acid Use
Interventions: DRUG: Tranexamic acid|OTHER: 5% Dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant ECS Versus ECF in Local Advanced Breast Cancer
Status: UNKNOWN
Conditions: Breast Neoplasms|Neoadjuvant Therapy
Interventions: DRUG: S-1|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema (YOSEMITE)
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Aflibercept|DRUG: Faricimab|PROCEDURE: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectivness of FODMAP Diet in Israel in Relieving Symptoms of Patients With Irritable Bowel Syndrome
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome
Interventions: OTHER: FODMAP diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Autologous Conditioned Serum: Functional and Clinical Results
Status: COMPLETED
Conditions: Knee Osteoarthritis|Osteoarthritis, Knee|Cartilage Degeneration
Interventions: DRUG: Autologous Conditioned Serum
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Ferric Carboxymaltose vs. Oral Iron Substitution in Patients With Metastatic Colorectal Cancer (CRC) and Iron Deficiency Anemia: a Randomized Multicenter Treatment Optimization Study.
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: FerInject|DRUG: Ferro sanol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Brain During Effort : Effects of Hypoxia With Respiratory Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)|Sleep Apnea Obstructive (OSA)|Healthy Volunteers
Interventions: BIOLOGICAL: Pedalling exercise on a cycle ergometer|BIOLOGICAL: Isolated contractions of the quadriceps
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: NEMOS in Normal Volunteer and JIA Study
Status: UNKNOWN
Conditions: Inflammatory Response
Interventions: DEVICE: Stimulation 10 minutes|DEVICE: NEMOS transvagal stimulation 60 minutes|DEVICE: NEMOS Device sham stimulation 10 minutes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Evaluation Of Pregabalin (Lyrica) With Patients With Generalized Anxiety Disorder
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: DRUG: Pregabalin|DRUG: Lorazepam|DRUG: Pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: How Does STN-DBS Influence Emotional Conflict Decision in Parkinson's Disease: a EEG Study
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: BEHAVIORAL: stroop test in condition DBS off|BEHAVIORAL: stroop test in condition DBS on
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: D2212C00002 J-Phase II Study
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: BIOLOGICAL: tralokinumab cohort 1|BIOLOGICAL: tralokinumab cohort 2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Efficacy and Safety of Nitazoxanide (NTZ) for Pre- and Post Exposure Prophylaxis of COVID-19 and Other Viral Respiratory Illnesses (VRI) in Healthcare Workers and Others at Increased Risk of SARS-CoV-2 Infection
Status: COMPLETED
Conditions: COVID-19|Viral Respiratory Illnesses
Interventions: DRUG: Nitazoxanide|DRUG: Placebo|DIETARY_SUPPLEMENT: Vitamin Super B-Complex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Dexamethason on Postimplantation Syndrome After EVAR
Status: NOT_YET_RECRUITING
Conditions: Aneurysm Abdominal|Endovascular Aneurysm Repair|Postimplantation Syndrome|Dexamethasone
Interventions: DRUG: Dexamethasone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vorinostat and Alvocidib in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: alvocidib|DRUG: vorinostat|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Pharmacokinetic Study of TVB-2640 (Denifanstat) in Subjects With Mild, Moderate, or Severe Hepatic Impairment Compared to Subjects With Normal Hepatic Function
Status: COMPLETED
Conditions: Non-alcoholic Steatohepatitis|Hepatic Impairment|Cirrhosis
Interventions: DRUG: TVB-2640 - 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Plus Vaccination to Treat Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Mantle Cell Lymphoma|Lymphoma, Mantle Cell
Interventions: DRUG: EPOCH-R|BIOLOGICAL: GM-CSF|BIOLOGICAL: Idiotype vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study of the Use of Nintedanib in Slowing Lung Disease in Patients With Fibrotic or Non-Fibrotic Interstitial Lung Disease Related to COVID-19
Status: COMPLETED
Conditions: Pulmonary Fibrosis|Interstitial Lung Disease|Respiratory Disease
Interventions: DRUG: Nintedanib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Immunotherapy Plus ADI-PEG 20 for the Treatment of Advanced Uveal Melanoma
Status: COMPLETED
Conditions: Uveal Melanoma
Interventions: DRUG: ADI PEG20|DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ridge Preservation Comparing 2 Membranes
Status: COMPLETED
Conditions: Alveolar Ridge Deficiency
Interventions: PROCEDURE: Non-resorbable membrane|PROCEDURE: Acellular dermal matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuropsychologic and Electrophysiological Features of Cancer-Related Cognitive Side Effects in Racial and Ethnic Minority Breast Cancer Patients
Status: TERMINATED
Conditions: Breast Cancer
Interventions: OTHER: EEG, Neuropsychological Evaluation, Psychological Questionnaires, Medical Questionnaire|OTHER: EEG, Neuropsychological Evaluation, Psychological Questionnaires, Medical Questionnaire|OTHER: EEG, Neuropsychological Evaluation, Psychological Questionnaires, Medical Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Durvalumab + Tremelimumab ± Paclitaxel in Advanced BTC After Platinum Chemotherapy.
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Biliary Tract Carcinoma
Interventions: DRUG: Durvalumab|DRUG: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rollover Study to Provide Continued Access to Napabucasin for Patients Enrolled in Boston Biomedical-sponsored Protocols
Status: COMPLETED
Conditions: Oncology
Interventions: DRUG: Napabucasin|DRUG: Nab-paclitaxel|DRUG: Gemcitabine|DRUG: Nivolumab|DRUG: Paclitaxel|DRUG: Irinotecan|DRUG: Leucovorin|DRUG: 5Fluorouracil|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Multi-Center Study of Sensory Stimulation to Improve Brain Function
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer Disease|Cognitive Impairment|Mild Cognitive Impairment|Dementia Alzheimers|Dementia, Mild|Dementia, Alzheimer Type|Dementia of Alzheimer Type|Dementia|Cognitive Impairment, Mild|Cognitive Decline
Interventions: DEVICE: GammaSense Stimulation System (Active Settings)|DEVICE: GammaSense Stimulation System (Sham Settings)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Test the Safety and Tolerability of PF-07209960 in Advanced or Metastatic Solid Tumors
Status: TERMINATED
Conditions: Non-small-cell Lung Cancer|Squamous Cell Carcinoma of the Head and Neck|Renal Cell Carcinoma|Urothelial Carcinoma|Colorectal Carcinoma|Ovarian Carcinoma
Interventions: BIOLOGICAL: PF-07209960
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Antihypertensive Drug Treatment on Brain Blood Flow, Cognition, and Regulation of Nervous System in Older Adults With Hypertension.
Status: NOT_YET_RECRUITING
Conditions: Essential Hypertension|Older Adults
Interventions: DRUG: chlorthalidone 25 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Psychosocial, Cognitive, and Behavioral Consequences of Sleep-disordered Breathing After SCI
Status: RECRUITING
Conditions: Spinal Cord Injuries|Sleep Apnea
Interventions: OTHER: Continuous positive airway pressure (CPAP) therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioactive Glass in the Treatment of Enamel White Spot Lesions
Status: COMPLETED
Conditions: White Spot Lesion of Tooth
Interventions: DRUG: BiominF|DRUG: Novamin|DRUG: CPP-ACP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Trivalent Subunit Inactivated Flu Vaccine Administered to Healthy Children and Adolescents 3 to 17 Years of Age
Status: COMPLETED
Conditions: Seasonal Influenza
Interventions: BIOLOGICAL: TIV|BIOLOGICAL: TIVf|BIOLOGICAL: Comparator TIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Spinae Erector Block (ESP) and Gabapentin on Recovery and Length of Stay in Adolescent Spinal Fusion Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Adolescent Idiopathic Scoliosis
Interventions: PROCEDURE: gabapentin + bilateral spine erector block
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Bioequivalence Study Between Fluticasone Salmeterol Xinafoate vs. SERETIDE DISKUS® in Healthy Volunteers With Charcoal Blockade (BREATH-PK250-CC)
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Fluticasone propionate 250 mcg and salmeterol xinafoate 50 mcg inhalation powder/Respirent Pharmaceuticals|DRUG: SERETIDE DISKUS® 250/50 inhalation powder/GSK|OTHER: Activated Charcoal suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: αPD1-MSLN-CAR T Cells for the Treatment of MSLN-positive Advanced Solid Tumors
Status: UNKNOWN
Conditions: Colorectal Cancer|Ovarian Cancer
Interventions: BIOLOGICAL: αPD1-MSLN-CAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BMAC Enhanced Coronary Artery Bypass Grafting (CABG)
Status: TERMINATED
Conditions: Congestive Heart Failure
Interventions: DEVICE: Harvest SmartPReP2 BMAC System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantitative Analysis of 18F-FAPI Dynamic PET/CT for Accurate Differential Diagnosis of MLN of ESCC
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma|Benign Lymph Node Neoplasm|Malignant Lymph Node Neoplasm
Interventions: DIAGNOSTIC_TEST: Dynamic PET/CT|DIAGNOSTIC_TEST: Dynamic PET/CT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p