pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Project RESPECT: The Efficacy of HIV/STD Prevention Counseling
Status: COMPLETED
Conditions: HIV|Sexually Transmitted Diseases
Interventions: BEHAVIORAL: "Enhanced HIV/STD Counseling:" 4 face-to-face, interctive counseling sessions based on the Theory of Reasoned Action & Health Belief Model|BEHAVIORAL: "Brief Counseling" (aka "client-centered counseling"): 2 brief, face-to-face interactive sessions targeted a patient-identified risk behavior|BEHAVIORAL: "HIV Prevention Education": 2 brief, didactic sessions informing the patient about HIV/STD prevention strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: Javelin BRCA/ATM: Avelumab Plus Talazoparib in Patients With BRCA or ATM Mutant Solid Tumors
Status: TERMINATED
Conditions: Locally Advanced or Metastatic Solid Tumors|Genes, BRCA 1
Interventions: DRUG: Avelumab|DRUG: Talazoparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intramedullary Headless Screw Fixation for Metacarpal and Phalangeal Fractures
Status: NOT_YET_RECRUITING
Conditions: Metacarpal Fracture|Phalanx Fracture
Interventions: PROCEDURE: Intramedullary headless screw fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Toripalimab Plus Bevacizumab and Chemotherapy as Neoadjuvant Therapy in Advanced MSI-H or dMMR Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Carcinoma
Interventions: DRUG: Toripalimab|DRUG: Bevacizumab|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of MLN0128 and MLN8237 in Patients With Advanced Solid Tumors and Metastatic Triple-negative Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer|Solid Tumors
Interventions: DRUG: Alisertib|DRUG: MLN0128
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Stimulation for Upper Limb Training of Individuals With Sequelae From Intracranial Hemorrhage
Status: UNKNOWN
Conditions: Cerebrovascular Disorders
Interventions: DEVICE: Transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of UGN-101 in Recurrent Patients
Status: WITHDRAWN
Conditions: Carcinoma|Transitional Cell Carcinoma|Transitional Cell Cancer of the Renal Pelvis and Ureter
Interventions: DRUG: UGN-101 instillations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Switch to Doravirine/Islatravir (DOR/ISL) in Human Immunodeficiency Virus 1 (HIV-1) Participants Treated With Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF) (MK-8591A-018)
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infection
Interventions: DRUG: DOR/ISL|DRUG: BIC/FTC/TAF|DRUG: Placebo to BIC/FTC/TAF|DRUG: Placebo to FDC DOR/ISL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sorafenib in Hormone Naïve Biochemical Recurrence of Prostate Cancer
Status: WITHDRAWN
Conditions: Prostate Cancer
Interventions: DRUG: Sorafenib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PROVHILO:Protective Ventilation During General Anesthesia for Open Abdominal Surgery
Status: COMPLETED
Conditions: Postoperative Respiratory Complications
Interventions: PROCEDURE: Lung protective strategy ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AKT Inhibitor, Ipatasertib, With Endocrine and CDK 4/6 Inhibitor for Patients With Metastatic Breast Cancer (TAKTIC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Ipatasertib|DRUG: Fulvestrant|DRUG: Aromatase Inhibitor|DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexametomedine Versus Ketamine as an Adjuvant in Erector Spinae Block for Perioperative Thoracotomy Pain Control
Status: COMPLETED
Conditions: Post Operative Pain
Interventions: DRUG: Bupivacaine|DRUG: Ketamine Hydrochloride|DRUG: Dexmedetomidine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intervention to Collect and Utilize Sexual Orientation and Gender Identity (SOGI) Information in Hospice
Status: RECRUITING
Conditions: Sexual and Gender Minorities|Hospice|Alzheimer's Disease and Related Dementias
Interventions: BEHAVIORAL: SGM Communication Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluate St Jude Medical Prodigy Neuromodulation for FBSS or Chronic Pain of the Trunk and/or Limbs
Status: COMPLETED
Conditions: Chronic Pain
Interventions: PROCEDURE: Burst and Tonic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Radial Extracorporeal Shock Waves and Botulinum Toxin Injection for Spasticity
Status: COMPLETED
Conditions: Post-Stroke Upper Limb Spasticity
Interventions: DEVICE: Shock Wave|DRUG: Botulinum toxin A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of Topically Applied LDE225 Cream (Hedgehog Pathway Inhibitor) in Adult Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS)
Status: WITHDRAWN
Conditions: Basal Cell Carcinoma
Interventions: DRUG: LDE225B|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Effect of Acetazolamide and NaHco3 in Prevention of Contrast Nephropathy
Status: COMPLETED
Conditions: Contrast Induced Nephropathy
Interventions: DRUG: sodium bicarbonate|DRUG: Acetazolamide|DRUG: normal salin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: BLOOM-DM: Behavioral Modification and Lorcaserin for Overweight and Obesity Management in Diabetes Mellitus
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Lorcaserin 10 mg once daily (QD)|DRUG: Lorcaserin 10 mg twice a day (BID)|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Readmissions: BNI Trial in Substance Use Disorder
Status: ACTIVE_NOT_RECRUITING
Conditions: Substance Use Disorders|Substance Withdrawal
Interventions: OTHER: Brief Negotiated Interview|OTHER: Narrative Interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combined Phacoemulsification With iStent Inject W Versus Hydrus for Mild to Moderate Open Angle Glaucoma
Status: RECRUITING
Conditions: Open Angle Glaucoma
Interventions: DEVICE: Combined cataract surgery with Hydrus microstent|DEVICE: Combined cataract surgery with iStent Inject W
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of GDX012 in Adults With Relapsed or Refractory Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Leukemia
Interventions: DRUG: GDX012|DRUG: Chemotherapy Agents
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Pilot Study of Radiosurgery for the Treatment of Non-metastatic Prostate Cancer
Status: RECRUITING
Conditions: Prostatic Neoplasms|Radiosurgery|Quality of Life
Interventions: RADIATION: External beam image guided radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Safety and Tolerability of Single and Multiple Doses of Padsevonil in Adult and Elderly Study Participants
Status: COMPLETED
Conditions: Elderly Study Participants|Adult Study Participants
Interventions: DRUG: Padsevonil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Multiple Myeloma Patients Relapsing or Progressing After Autologous Transplantation on Total Therapy 2
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Velcade, Thalidomide, and Dexamethasone|DRUG: Velcade, Melphalan, and Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Pharmacokinetics of Fidaxomicin in Inflammatory Bowel Disease (IBD) Subjects With Clostridium Difficile Infection (CDI)
Status: COMPLETED
Conditions: Inflammatory Bowel Disease (IBD)|Clostridium Difficile Infection (CDI)
Interventions: DRUG: fidaxomicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomised Trial of Doppler-Optimised Fluid Balance in Elective Colectomy
Status: COMPLETED
Conditions: Colorectal Cancer|Colectomy|Surgery|Perioperative Care
Interventions: DEVICE: Oesophageal Doppler|PROCEDURE: Intraoperative fluid restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Research Study Looking at New Protein-based Tablets in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy Volunteers|High Blood Cholesterol Levels|Type 2 Diabetes
Interventions: DRUG: Semaglutide D|DRUG: Semaglutide G|DRUG: Semaglutide H|DRUG: Semaglutide I|DRUG: NNC0385-0434 B|DRUG: NNC0385-0434 C|DRUG: NNC0385-0434 D|DRUG: NNC0385-0434 E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Stem Cell Infusion Time on aGVHD in Patients With Nonmalignant Hematologic Diseases
Status: NOT_YET_RECRUITING
Conditions: Acute Graft-versus-host Disease
Interventions: PROCEDURE: Time of stem cell infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bronchial Thermoplasty: Effect on Neuronal and Chemosensitive Component of the Bronchial Mucosa
Status: UNKNOWN
Conditions: Severe Persistent Asthma
Interventions: DEVICE: catheter ALAIR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Liposomal Bupivacaine in Thoracic Paravertebral Nerve Block
Status: NOT_YET_RECRUITING
Conditions: Thoracic Paravertebral Block|Postoperative Analgesia|Thoracoscopic Lobectomy
Interventions: DRUG: Liposomal bupivacaine, Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Bifidobacterium and Polydextrose on Body Fat Mass
Status: COMPLETED
Conditions: Obesity|Hyperglycemia|Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: Bifidobacterium animalis ssp. lactis 420|DIETARY_SUPPLEMENT: Polydextrose|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Moderately-high dose of psilocybin|DRUG: Moderately-low dose of psilocybin|DRUG: Very-low dose of psilocybin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nighttime Protein Intake on Overnight Lipolysis and Morning Fat Oxidation in Obese Men
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: Casein Protein|OTHER: Non-caloric placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 2B or Not 2B? Shoulder Function After Level 2B Neck Dissection: A Randomized Controlled Study
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: PROCEDURE: Selective Neck Dissection Excluding Level 2B|PROCEDURE: Selective Neck Dissection Including Level 2B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Natrunix or Placebo in Combination With Methotrexate in Rheumatoid Arthritis
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Natrunix|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Once-daily Versus Twice-daily Immunosuppressant on Renal Transplant
Status: UNKNOWN
Conditions: Adherence to Medication Regime
Interventions: DRUG: Advagraf|DRUG: Prograf
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Postprandial Blood Amino Acid Response
Status: COMPLETED
Conditions: Protein Digestion Kinetics
Interventions: DIETARY_SUPPLEMENT: Whey protein concentrate|DIETARY_SUPPLEMENT: Yoghurt|DIETARY_SUPPLEMENT: 50%whey-50% casein (Standard)|DIETARY_SUPPLEMENT: 50%whey-50% casein (Alternative)|DIETARY_SUPPLEMENT: Micellar Casein Isolate- WPH|DIETARY_SUPPLEMENT: Micellar Casein Isolate - Na-caseinate|DIETARY_SUPPLEMENT: Micellar Casein Isolate|DIETARY_SUPPLEMENT: UHT milk|DIETARY_SUPPLEMENT: Recombined milk|DIETARY_SUPPLEMENT: Recombined 50%whey milk|DIETARY_SUPPLEMENT: Ca-caseinate|DIETARY_SUPPLEMENT: Milk protein isolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate How VI-0521 Affect Cardiac Repolarization in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Torsades de Pointes
Interventions: DRUG: VI-0521
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Non-interventional Study to Evaluate Patient and Healthcare Provider Satisfaction of Daratumumab Use in the Treatment of First-line Daratumumab, Lenalidomide, Dexamethasone (DRd) Multiple Myeloma Patients in Germany Depending on Application Route (sc or iv)
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma|Newly Diagnosed|Transplant Ineligible|Patient Satisfaction|Patient Preference|Personal Satisfaction
Interventions: BIOLOGICAL: Daratumumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Obesity Control by Astragalus and Notoginseng Extrats
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: InnoSlim|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of Fluticasone Furoate/Vilanterol Versus (vs) Fluticasone Furoate on Asthma
Status: WITHDRAWN
Conditions: Asthma
Interventions: DRUG: Fluticasone Furoate/Vilanterol|DRUG: Fluticasone Furoate|DRUG: Salbutamol/Albuterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: High Risk Primitive Neuroectodermal (PNET) Brain Tumors in Childhood
Status: UNKNOWN
Conditions: Medulloblastoma|Brain Tumors|Neuroectodermal Tumors, Primitive
Interventions: DRUG: Etoposide, carboplatin, melphalan, cisplatin, thiotepa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Clinical, Biological Characteristics and Quality of Life of Patients With Hereditary or Acquired Non Drug-induced Bradykinin-mediated Angioedema, Monitored in Besançon's Partner Site Reference Center for Studies of Kinin-mediated Angioedema (CREAK)
Status: COMPLETED
Conditions: Angioedema
Interventions: OTHER: Quality of life
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CD8+ T Cell Therapy and Pembrolizumab in Treating Patients With Metastatic Gastrointestinal Tumors
Status: TERMINATED
Conditions: Colorectal Adenocarcinoma|Metastatic Cholangiocarcinoma|Metastatic Colorectal Carcinoma|Metastatic Digestive System Carcinoma|Metastatic Esophageal Carcinoma|Metastatic Gastric Carcinoma|Metastatic Pancreatic Adenocarcinoma|Stage IV Colorectal Cancer AJCC v7|Stage IV Esophageal Cancer AJCC v7|Stage IV Gastric Cancer AJCC v7|Stage IV Pancreatic Cancer AJCC v6 and v7|Stage IVA Colorectal Cancer AJCC v7|Stage IVB Colorectal Cancer AJCC v7
Interventions: BIOLOGICAL: Adoptive Immunotherapy|BIOLOGICAL: Aldesleukin|DRUG: Cyclophosphamide|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home Versus Hospital Based Action Observation Therapy in Diaplegic Cerebral Palsy
Status: COMPLETED
Conditions: Diplegic Cerebral Palsy
Interventions: OTHER: Action observation at home|OTHER: Action Observation therapy at hospital
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nutrients-fortified Egg Consumption on Eczema Condition in Individuals With Eczema
Status: ACTIVE_NOT_RECRUITING
Conditions: Eczema, Atopic|Inflammation; Skin|Eczema|Hypersensitivity
Interventions: DIETARY_SUPPLEMENT: Nutrients-fortified egg|OTHER: Regular egg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Atelectasis After Pulmonary Lobectomy: The Effect Of Air During One-Lung Ventilation (OLV) On Postoperative Atelectasis
Status: UNKNOWN
Conditions: Pulmonary Atelectasis
Interventions: OTHER: One Lung Ventilation|OTHER: One Lung Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MgSO4 Combined With Rocuronium Priming
Status: UNKNOWN
Conditions: Muscle Relaxation
Interventions: DRUG: magnesium sulfate|DRUG: priming|DRUG: magnesium sulfate and priming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of the Pecha-Kucha Method on the Discharge Readiness and Anxiety Levels
Status: COMPLETED
Conditions: Anxiety|Post Procedural Discharge|PechaKucha Method
Interventions: BEHAVIORAL: The postpartum discharge education with PechaKucha Method.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Move ARound And Get Active: an Intervention to Optimize 24-hour Movement Behaviours in Preschoolers
Status: RECRUITING
Conditions: Parents|Child Behavior|Child Obesity|Physical Inactivity|Sedentary Behavior|Sedentary Time|Sleep|Parenting
Interventions: BEHAVIORAL: Move-ARound And Get Active
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Investigating the Role of Impella 2.5 System in Acutely Decompensated Chronic Heart Failure Patients
Status: TERMINATED
Conditions: Heart Failure
Interventions: DEVICE: Impella 2.5
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spot-Scanning Based Hypofractionated Proton Therapy for Low and Intermediate Risk Prostate Cancer
Status: RECRUITING
Conditions: Low Risk Prostate Cancer|Intermediate Risk Prostate Cancer
Interventions: OTHER: EPIC questionnaire|RADIATION: kV x-ray images|RADIATION: Conebeam CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase III Study Evaluating the Efficacy and Safety of Satavaptan Versus Placebo in Patients With Dilutional Hyponatremia
Status: TERMINATED
Conditions: Hyponatremia|Inappropriate ADH Syndrome
Interventions: DRUG: Satavaptan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of Fusilev® to Prevent or Reduce Mucositis in Patients With Non-Small Cell Lung Cancer Receiving Folotyn®
Status: WITHDRAWN
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Folotyn|DRUG: Fusilev
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Safety and Potential Therapeutic Effects of CB-AC-02 in Patients With Alzheimer's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer's Disease
Interventions: BIOLOGICAL: CB-AC-02|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Therapy With Apatinib for HCC Patients With PVTT Who Underwent Radical Resection
Status: UNKNOWN
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography/Computed Tomography Scanning Before Surgery in Patients With Non-Small Cell Lung Cancer, Colorectal Cancer, Breast Cancer, Esophageal Cancer, or Head and Neck Cancer
Status: UNKNOWN
Conditions: Breast Cancer|Colorectal Cancer|Esophageal Cancer|Head and Neck Cancer|Lung Cancer
Interventions: OTHER: 18F-fluoromisonidazole|OTHER: fluorescence angiography|OTHER: laboratory biomarker analysis|PROCEDURE: infrared thermography|PROCEDURE: magnetic resonance imaging|PROCEDURE: therapeutic conventional surgery|RADIATION: [18F]-ML-10|RADIATION: fludeoxyglucose F 18|RADIATION: rubidium Rb-82
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: Cardboard Cot: Prevention of Moderate or Severe Hypothermia in Preterm Infants Assigned to Open Crib
Status: WITHDRAWN
Conditions: Infant, Premature
Interventions: OTHER: Cardboard Cot Care|OTHER: Open Crib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Atezolizumab in Combination With Nab-Paclitaxel Compared With Placebo With Nab-Paclitaxel for Participants With Previously Untreated Metastatic Triple-Negative Breast Cancer (IMpassion130)
Status: COMPLETED
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Atezolizumab (MPDL3280A), an engineered anti-PDL1 antibody|DRUG: Nab-Paclitaxel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Deep Brain Stimulation (DBS) Frequency Effects on Gait in Parkinson's Disease(PD)
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: PROCEDURE: Frequency change to 60 Hz|PROCEDURE: Frequency change to 130 Hz
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Once Daily Versus 8 Hour Dosing of Gentamicin for the Treatment of Intrapartum Chorioamnionitis
Status: COMPLETED
Conditions: Chorioamnionitis
Interventions: DRUG: gentamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cixutumumab and Temsirolimus in Treating Patients With Locally Recurrent or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Male Breast Carcinoma|Recurrent Breast Carcinoma|Stage IV Breast Cancer AJCC v6 and v7
Interventions: BIOLOGICAL: Cixutumumab|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prenatal Administration of Spermine Promotes Maturation of Premature Fetal Gut Epithelial Tight Junction: Experimental Study on Fetal Rabbit
Status: COMPLETED
Conditions: Premature Birth|NEC
Interventions: BIOLOGICAL: Spermine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PET Study of a2a Agonist Effects on the Ventricular CSF Clearance of [11C]Butanol
Status: WITHDRAWN
Conditions: Healthy Volunteers
Interventions: DRUG: Clonidine Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Modified Thoracoabdominal Nerve Plane Block In Laparoscopic Sleeve Gastrectomy
Status: NOT_YET_RECRUITING
Conditions: Obesity|Bariatric Surgery|Laparoscopic Sleeve Gastrectomy|Acute Post Operative Pain
Interventions: PROCEDURE: M-TAPA block|PROCEDURE: Postoperative pain management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Bundled Supportive Interventions on Preterm Infants' Stress-Related Outcomes During Invasive Procedures
Status: COMPLETED
Conditions: Preterm Infants|Stress
Interventions: BEHAVIORAL: The bundle of supportive interventions|BEHAVIORAL: Usual NICU care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Spironolactone and Amiloride on Home Blood Pressure in Resistant Hypertension
Status: COMPLETED
Conditions: Resistant Hypertension
Interventions: DRUG: Spironolactone|DRUG: Amiloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Investigate if SAR425899 Binds to the Liver and Pancreas in Overweight to Obese Type 2 Diabetes Mellitus Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: SAR425899|DRUG: [68Ga] Ga-DO3A-VS-Cys40-Tuna-2 (glucagon receptor tracer)|DRUG: [68Ga] Ga-DO3A-VS-Cys40-Exendin-4 (GLP-1 receptor tracer)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: External Oblique Intercostal Plane Block vs. Transversus Abdominis Plane Block for Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Analgesia
Interventions: OTHER: ultrasound guided external oblique intercostal plane block|OTHER: Subcostal Transversus Abdominis Plan Block Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Blueberries for Improving Vascular Endothelial Function in Postmenopausal Women With Elevated Blood Pressure
Status: COMPLETED
Conditions: Menopause|Elevated Blood Pressure|Hypertension|Endothelial Dysfunction
Interventions: DIETARY_SUPPLEMENT: Blueberry Powder|DIETARY_SUPPLEMENT: Placebo Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Exercise Training on Corticospinal System in Overhead Athletes With Shoulder Impingement Syndrome
Status: COMPLETED
Conditions: Shoulder Impingement Syndrome|Transcranial Magnetic Stimulation|Central Nervous System|Biomechanical Phenomena
Interventions: PROCEDURE: Scapula control exercise|PROCEDURE: scapular strengthening exercise|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sonrotoclax, Zanubrutinib and CD20mab in Untreated MCL Patients
Status: NOT_YET_RECRUITING
Conditions: MCL
Interventions: DRUG: BGB-11417|DRUG: BGB-3111|DRUG: CD20
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Omega-3 Fatty Acid Supplementation and Physical Training on Metabolic Health
Status: WITHDRAWN
Conditions: Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: DPA enriched n-3|DIETARY_SUPPLEMENT: n-3 control|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study in Patients With COVID-19 and Respiratory Distress Not Requiring Mechanical Ventilation, to Compare Standard-of-care With Anakinra and Tocilizumab Treatment The Immunomodulation-CoV Assessment (ImmCoVA) Study
Status: UNKNOWN
Conditions: Covid-19
Interventions: DRUG: Anakinra Prefilled Syringe|DRUG: Tocilizumab Prefilled Syringe|DRUG: Standard-of-care treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in People With Normal Kidney Function and People With Reduced Kidney Function to Test How BI 1467335 is Processed in the Body
Status: COMPLETED
Conditions: Renal Insufficiency|Healthy
Interventions: DRUG: BI 1467335
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Umbilical Cord Mesenchymal Stem Cells Treatment for Lupus Nephritis (LN)
Status: UNKNOWN
Conditions: Lupus Nephritis
Interventions: OTHER: Mesenchymal stem cells|DRUG: Mycophenolate Mofetil|OTHER: Placebo of Mesenchymal stem cells|DRUG: Placebo of Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Nitroprusside on Intrauterine Device (IUD) Insertion
Status: COMPLETED
Conditions: Cervical Pain|Pelvic Pain
Interventions: PROCEDURE: Nitroprusside Gel|PROCEDURE: Placebo Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of INKmune in Patients With mCRPC (CaRe Prostate)
Status: RECRUITING
Conditions: Cancer|Metastatic Castration-resistant Prostate Cancer|mCRPC
Interventions: BIOLOGICAL: INKmune
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Treatment of Experimental Pain in Buprenorphine Maintained Persons With Chronic Musculoskeletal Pain
Status: COMPLETED
Conditions: Opioid-Related Disorders|Chronic Pain
Interventions: DRUG: Buprenorphine|DRUG: Hydromorphone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COvid-19 Vaccine Booster in Immunocompromised Rheumatic Diseases
Status: RECRUITING
Conditions: Rheumatoid Arthritis|Autoimmune Rheumatologic Disease|Systemic Lupus Erythematosus|Systemic Vasculitis|Systemic Sclerosis|Scleroderma|Undifferentiated Connective Tissue Diseases|Overlap Connective Tissue Disease|Immunosuppression
Interventions: BIOLOGICAL: COVID-19 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Central Nervous System Tumor, Pediatric|Glioma|Ependymoma|Medulloblastoma|Germ Cell Tumor|Atypical Teratoid/Rhabdoid Tumor|Primitive Neuroectodermal Tumor|Choroid Plexus Carcinoma|Pineoblastoma
Interventions: BIOLOGICAL: HER2-specific chimeric antigen receptor (CAR) T cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Booster Dose Study to Assess the Safety and Immunogenicity of ACM-001 Administered Intramuscularly or Intranasally.
Status: COMPLETED
Conditions: SARS-CoV-2 Infection
Interventions: BIOLOGICAL: ACM-SARS-CoV-2-beta ACM-CpG vaccine candidate (ACM-001)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Local Steroid Application on a Cervical Plate Versus Intravenous Steroids on Dysphagia Following Anterior Cervical Discectomy and Fusion (ACDF)
Status: COMPLETED
Conditions: Cervical Spine
Interventions: DRUG: Decadron|DRUG: Triamcinolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Bone Marrow Transplantation Followed by Graft-versus-Host-Disease (GVHD) Prophylaxis With Cyclophosphamide, Bortezomib and Maraviroc for Hematologic Malignancies in People Living With HIV
Status: SUSPENDED
Conditions: HIV|Hematologic Malignancies
Interventions: DRUG: RIC|DRUG: GVHD prophylaxis|PROCEDURE: allo HCT|DRUG: Plerixafor|DRUG: Maraviroc
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CANA/Met in Non-diabetic Women With PCOS
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Canagliflozin combined with metformin|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nimotuzumab Plus Tislelizumab for Recurrent and Metastatic Cervical Cancer
Status: NOT_YET_RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: Nimotuzumab、Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Live Attenuated Inactivated Influenza Vaccine on Experimental Human Pneumococcal Carriage Study
Status: COMPLETED
Conditions: Pneumonia|Influenza, Human
Interventions: BIOLOGICAL: Study one: LAIV + Inoculation|BIOLOGICAL: Study one: Placebo + Inoculation|BIOLOGICAL: Study two: Inoculation + LAIV|BIOLOGICAL: Study two: Inoculation + placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Assess the Effect of Ketoconazole on the Pharmacokinetics of Linifanib (ABT-869)
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: ABT-869|DRUG: ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Emmy Trial: Uterine Artery Embolization (UAE) Versus Hysterectomy for Uterine Fibroids
Status: COMPLETED
Conditions: Menorrhagia|Leiomyoma|Uterine Neoplasms
Interventions: PROCEDURE: uterine artery embolization|PROCEDURE: hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile Instant Messaging-based Lifestyle Intervention for Gestational Diabetes Prevention
Status: RECRUITING
Conditions: Gestational Diabetes
Interventions: BEHAVIORAL: Mobile instant messaging-based lifestyle intervention|BEHAVIORAL: Text messaging reminders|BEHAVIORAL: Brief advice on GDM prevention|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treating Primary Progressive Aphasia (PPA) Using High-definition tDCS
Status: RECRUITING
Conditions: Primary Progressive Aphasia
Interventions: DEVICE: high-definition transcranial direct current stimulation|BEHAVIORAL: modified constraint-induced language therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Sibutramine in Overweight Non-Diabetic Malaysian Population
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Sibutramine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Diabetes Group Visits Across Health Systems
Status: RECRUITING
Conditions: T2DM (Type 2 Diabetes Mellitus)|Hypertension|Heart Disease Chronic|Stroke|Hyperlipidemias|Peripheral Vascular Diseases|Obesity
Interventions: BEHAVIORAL: Virtual Group Visit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase II Prospective, Single Blinded, Randomized Trial of Hemopatch Compared to Standard Techniques to Achieve Air Leak Control After Complex Thoracic Surgical Procedures
Status: ACTIVE_NOT_RECRUITING
Conditions: Thoracic Surgery Lung|Post-operative Thoracic Air Leak
Interventions: DEVICE: standard techniques used to achieve air leak control|DEVICE: Hemopatch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Non-Hodgkin Lymphoma With CD19-TriCAR-T/SILK Cell Therapy
Status: UNKNOWN
Conditions: Non-Hodgkin Lymphoma
Interventions: BIOLOGICAL: CD19-TriCAR-T/SILK
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lactobacillus Reuteri Alleviates Oral Mucositis in Patients Undergoing Radiotherapy for Malignant Head and Neck Tumors
Status: RECRUITING
Conditions: Oral Mucositis (Ulcerative) Due to Radiation
Interventions: DIETARY_SUPPLEMENT: Lactobacillus Reuteri Tablets|DIETARY_SUPPLEMENT: Placebo-containing tablets|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Novel Approach to Plantar Fasciitis in the Aging Population
Status: RECRUITING
Conditions: Plantar Fasciitis, Chronic
Interventions: DEVICE: minimal shoes and foot strengthening and flexibility exercises|DEVICE: Supportive Footwear, foot orthotic device and foot flexibility exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study On Safety Of Endoscopic Resection For 2-5cm Gastric Gastrointestinal Stromal Tumor
Status: UNKNOWN
Conditions: Gastric GIST
Interventions: PROCEDURE: Endoscopic resection|PROCEDURE: Laparoscopic partial gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transvaginal Versus Transperineal Repair of Rectocele
Status: COMPLETED
Conditions: Rectocele
Interventions: PROCEDURE: Transvaginal repair|PROCEDURE: Transperineal repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reactogenicity, Safety and Immunological Efficacy of the Live, Pentavalent Rotavirus Vaccine in Childhood Immunization
Status: COMPLETED
Conditions: Rotavirus Infection
Interventions: BIOLOGICAL: The pentavalent rotavirus vaccine (live attenuated oral, freeze-dried)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Low Sodium Oxybate in Patients With Idiopathic Hypersomnia
Status: RECRUITING
Conditions: Idiopathic Hypersomnia
Interventions: DRUG: Low Sodium Oxybate|DIAGNOSTIC_TEST: 24-hour polysomnography|DEVICE: Nextsense EEG earbuds|DEVICE: Axivity device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ABT-199 & Ibrutinib in Mantle Cell Lymphoma (AIM)
Status: ACTIVE_NOT_RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: ABT-199|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotics in Intestinal Bacterial Overgrowth
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Probiotics in SIBO|DIETARY_SUPPLEMENT: Probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nasal High Frequency Oscillation Ventilation(NHFOV) for Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Respiratory Distress Syndrome|Preterm Infant
Interventions: DEVICE: NHFOV|DEVICE: NCPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Orosol® in the Treatment of Chemo- and Radiation-induced Mucositis.
Status: RECRUITING
Conditions: Oral Mucositis
Interventions: DEVICE: Topical application of Orosol®|DEVICE: Topical application of Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Systemic Application of Cadonilimab, LM-302, and S-1 Combined With Intraperitoneal Infusion of Paclitaxel for the Treatment of Claudin 18.2-positive Gastric Cancer With Peritoneal Metastasis
Status: RECRUITING
Conditions: Gastric Cancer Stage IV|Peritoneal Metastases
Interventions: DRUG: Cadonilimab, LM-302, S-1, paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Awake Axillary Impella 5.5 Placement - A Feasibility Trial
Status: WITHDRAWN
Conditions: Cardiogenic Shock
Interventions: PROCEDURE: Interscalene Block|PROCEDURE: PECS II Block|PROCEDURE: Superficial Cervical Plexus Block
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double Blind Randomized Placebo Controlled Trial of Natrecor in Acute Decompensated Heart Failure With Normal EF
Status: WITHDRAWN
Conditions: Heart Failure, Congestive|Dyspnea|Pulmonary Edema
Interventions: DRUG: Nesiritide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Irinotecan Liposome Injection-containing Regimens Versus Nab-paclitaxel Plus Gemcitabine in Patients With Previously Untreated, Metastatic Pancreatic Adenocarcinoma
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Cancer Non-resectable|Pancreatic Cancer Metastatic
Interventions: DRUG: Irinotecan Liposome Injection|DRUG: Fluorouracil|DRUG: Leucovorin|DRUG: Oxaliplatin|DRUG: Nab paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rizatriptan for Episodic Dizziness in Vestibular Migraine
Status: COMPLETED
Conditions: Vestibular Migraine|Migrainous Vertigo
Interventions: DRUG: Rizatriptan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effectiveness of Prednisone, Azathioprine, and N-acetylcysteine in Patients With IPF
Status: COMPLETED
Conditions: Pulmonary Fibrosis
Interventions: DRUG: N-acetylcysteine (NAC)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Electronic Clinical Decision Support Tool to Reduce Low-value Antipsychotic Prescriptions
Status: ENROLLING_BY_INVITATION
Conditions: Alzheimer Disease|Dementia Alzheimers|Dementia of Alzheimer Type
Interventions: BEHAVIORAL: EHR CDS|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH