pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment
Status: RECRUITING
Conditions: Primary Myelofibrosis (PMF)|Post-Polycythemia Vera MF (Post-PV-MF)|Post-Essential Thrombocythemia MF (Post-ET-MF)
Interventions: DRUG: KRT-232|DRUG: Best Available Therapy (BAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HEAL-HF: A Cardiac Resynchronization Therapy (CRT) Outcomes Study
Status: TERMINATED
Conditions: Heart Failure, Congestive
Interventions: PROCEDURE: Acute hemodynamic assessment using PV Loops (CD Leycom, The Netherlands) during LV lead placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sedation During Bronchoscopy:Dexmedetomidine vs Alfentanil
Status: COMPLETED
Conditions: Bronchoscopy|Conscious Sedation
Interventions: DRUG: xylocain|DRUG: Alfentanil|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Performance of NER1008 Enema Compared With Fleet® Enema in Bowel Cleansing
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DEVICE: NER1008 enema|DRUG: Fleet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: Family Supportive Supervisor Training and Workplace Assessment Tool
Status: COMPLETED
Conditions: Psychosocial Deprivation|Work-Related Stress|Life-work Imbalance
Interventions: BEHAVIORAL: Family Supportive Supervisor Training 2.0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Fluid Management Guided by Pulse Pressure Variation Vs Central Venous Pressure on Lung Water Assessed by Lung Ultrasound During Liver Transplantation
Status: COMPLETED
Conditions: Lung; Congestive|Liver Transplantation
Interventions: OTHER: fluid therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of ALKS 9072 in Subjects With Chronic Stable Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: ALKS 9072, Low dose|DRUG: ALKS 9072, Med dose|DRUG: ALKS 9072, High dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ascending Doses of Autologous FDP vs FFP
Status: COMPLETED
Conditions: Freeze Dried Plasma in Healthy Volunteers
Interventions: BIOLOGICAL: Autologous Freeze Dried Plasma (FDP)|BIOLOGICAL: Fresh Frozen Plasma (FFP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: UM171 Expanded Cord Blood In Patients With High-Risk Acute Leukemia/Myelodysplasia
Status: ACTIVE_NOT_RECRUITING
Conditions: High Risk Hematologic Malignancy|Cord Blood Transplant
Interventions: BIOLOGICAL: Transplant with an expanded ECT-001 cord blood
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Influence of Apnea on Cardiac Function Using Cardiac Magnetic Resonance Imaging.
Status: COMPLETED
Conditions: Physiological Changes in Deliberate Apnea
Interventions: DEVICE: magnetic resonance imaging (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Adebrelimab in Combination With NALIRIFOX in Locally Advanced Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Adebrelimab|DRUG: Oxaliplatin 100 MG|DRUG: Irinotecan liposome|DRUG: Calcium Folinate|DRUG: Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Oxybutynin Topical Gel on Gastric Emptying
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxybutynin Chloride Gel|DRUG: Placebo Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Use of Five-strand Hamstring Autograft to Increase the Graft Size in Anterior Cruciate Ligament Reconstruction - a Prospective Randomized Controlled Trial
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament Injuries
Interventions: OTHER: 5-strand hamstring graft preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Magnesium on Exercise Tolerance, Quality of Life and Clinical Outcomes in Chronic Heart Failure Patients
Status: RECRUITING
Conditions: Magnesium Deficiency|Heart Failure
Interventions: DRUG: Placebo Oral Tablet|DRUG: Magnesium Oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: How to Reduce Pain in Patients Undergoing Office Hysteroscopy.
Status: NOT_YET_RECRUITING
Conditions: Pain
Interventions: DRUG: Celecoxib 200 mg, Hyoscine-N-butyl bromide (HBB), placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effect of NN5401 With the Effect of NN1250 and Insulin Aspart in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin degludec|DRUG: insulin degludec/insulin aspart|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Levels of Pain and Discomfort Between Two Methods of Leveling and Alignment
Status: COMPLETED
Conditions: Crowding
Interventions: PROCEDURE: Corticision|PROCEDURE: Traditional orthodontic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zanubrutinib Combined With R-CHOP Regimen in the Treatment of Newly Diagnosed DLBCL With High-risk Factors
Status: NOT_YET_RECRUITING
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: Zanubrutinib|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Epirubicin|DRUG: Vincristine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of UFT/Leucovorin, Radiotherapy With or Without Cetuximab Following Induction Gemcitabine Plus Capecitabine in Patients With Locally Advanced Pancreatic Cancer (PERU)
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: OTHER: UFT, Leucovorin|OTHER: UFT/ Leucovorin + Cetuximab + Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Hyperemia With the Use of Ocular Prostaglandin Analogues
Status: COMPLETED
Conditions: Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Bimatoprost 0.03%|DRUG: travoprost 0.004%|DRUG: latanoprost 0.005% eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Vilazodone on Glutamate in the Anterior Cingulate Cortex in Anxious Unipolar Depressives
Status: WITHDRAWN
Conditions: Major Depressive Disorder|Anxiety|Comorbidity
Interventions: DRUG: Vilazodone|DRUG: Citalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Pilates and Conventional Treatment in Addition to Pilates in Patients With Chronic Neck Pain
Status: COMPLETED
Conditions: Chronic Neck Pain
Interventions: OTHER: Clinical Pilates Exercises|OTHER: Clinical Pilates Exercises and Conventional Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Broccoli Sulforaphane Bioavailability With Mustard
Status: COMPLETED
Conditions: Sulforaphane Bioavailability
Interventions: DIETARY_SUPPLEMENT: Broccoli seed extract|DIETARY_SUPPLEMENT: Broccoli seed extract with mustard seed powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cognitive Behavioral Therapy (CBT) for Nightmares in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) Veterans
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder|Sleep Disorders|Nightmares
Interventions: BEHAVIORAL: CBT for Insomnia plus Imagery Rehearsal|BEHAVIORAL: CBT for Insomnia plus psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Disease Self-management Program Through a Mobile Applications for Patients With Hypertension
Status: COMPLETED
Conditions: Hypertension|Self-management|Mobile Applications
Interventions: BEHAVIORAL: DSMP through a Mobile Applications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study of BSZY Cream Intervention to Relieve Atopic Facial Dermatitis
Status: RECRUITING
Conditions: Atopic Dermatitis of Face (Diagnosis)
Interventions: OTHER: BSZY Cream|OTHER: emulsion matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Efficacy of CNN in Predicting Intraoperative Complications and Postoperative Outcomes in SMILE
Status: RECRUITING
Conditions: Deep Convolutional Neural Network|Small-incision Lenticule Extraction (SMILE) Surgery|Intraoperative Complications
Interventions: DIAGNOSTIC_TEST: AI diagnostic algorithm
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Verify if Amelogenins Had Some Benefits in Improving Lower 2nd Molar Periodontal Healing After 3rd Molar Extraction
Status: COMPLETED
Conditions: Attachment Loss, Periodontal|Teeth, Impacted
Interventions: DRUG: Amelogenin|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: APRiCOT-P: Study of Apricoxib With Gemcitabine and Erlotinib to Treat Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer|Metastatic Pancreatic Cancer
Interventions: DRUG: gemcitabine|DRUG: placebo|DRUG: Erlotinib|DRUG: apricoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Study in Healthy Volunteers to Identify Factors Influencing Bioequivalence Studies on Moderately Lipophilic Drugs Using Dermal Open Flow Microperfusion (dOFM)
Status: COMPLETED
Conditions: Healthy|Dermal Pharmacokinetic Measurements
Interventions: DRUG: Lidocaine 2.5% and Prilocaine 2.5% cream, USP (Actavis Pharma incorporated, USA)|DRUG: Lidocaine 2.5% and Prilocaine 2.5% cream (E. Fougera & Co. a division of Fougera Pharmaceuticals Inc., USA)|DRUG: Oraqix Parodontal-Gel (Dentsply Detrey GmbH, Germany)|DEVICE: Dermal open flow microperfusion|PROCEDURE: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Bone Turnover With Exposure to a GLP-1 Receptor Agonist
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus|Bone Remodeling
Interventions: DRUG: exenatide|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Nab®-Paclitaxel With CC-486 or Nab®-Paclitaxel With Durvalumab, and Nab®-Paclitaxel Monotherapy as Second/Third-line Treatment for Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: nab-paclitaxel IV|DRUG: CC-486|DRUG: Duravalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Aerobic Exercise on Cognition,Cerebral Brain Flow and Mental Health Among Traumatic Brain Injury Patients
Status: RECRUITING
Conditions: Cardiology|Psychiatry
Interventions: DEVICE: telehealth-based aerobic walking exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Home Telemanagement (UC HAT) Trial for Patients With Ulcerative Colitis
Status: COMPLETED
Conditions: Inflammatory Bowel Disease|Ulcerative Colitis
Interventions: OTHER: UC Home Automated Telemanagement|OTHER: Best Available Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of MLN4924 Plus Azacitidine in Treatment-naive Participants With Acute Myelogenous Leukemia (AML) Who Are 60 Years or Older
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia
Interventions: DRUG: MLN4924|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Nanoparticle-based Paclitaxel vs Solvent-based Paclitaxel as Part of Neoadjuvant Chemotherapy for Early Breast Cancer (GeparSepto)
Status: COMPLETED
Conditions: Tubular Breast Cancer Stage II|Mucinous Breast Cancer Stage II|Breast Cancer Female NOS|Invasive Ductal Breast Cancer|Tubular Breast Cancer Stage III|HER-2 Positive Breast Cancer|Inflammatory Breast Cancer Stage IV|Inflammatory Breast Cancer
Interventions: DRUG: nab-Paclitaxel|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Hematopoietic Stem Cell Transplantation
Status: UNKNOWN
Conditions: Solid Tumors|Hematologic Neoplasms
Interventions: DRUG: Fludarabine, Busulfan, Thymoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Investigating the Effects of UVC Beam and Laser Beam Therapy According to Standard Therapy in Patients With Covid-19 Diagnosis
Status: UNKNOWN
Conditions: Covid19
Interventions: DEVICE: Test Group: experimental - UVC Therapy applied
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assess the Efficacy of Whole Brain Radiation Therapy in Lung Cancer Patients With Brain Metastasis
Status: TERMINATED
Conditions: EGFR-mutated Lung Adenocarcinoma|Brain Metastasis
Interventions: OTHER: whole brain radiotherapy|DRUG: Gefitinib (IRESSA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bracing and Strengthening for Posterior Tibial Tendon Dysfunction
Status: COMPLETED
Conditions: Posterior Tibial Tendon Dysfunction
Interventions: DEVICE: Bracing|OTHER: Strengthening exercises|OTHER: Stretching exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Priming Constituents in Patients Undergoing CPB Assisted Cardiac Surgery: HES 130/0.4 or Albumin 5%
Status: WITHDRAWN
Conditions: Coronary Artery Disease|Aortic Valve Disease|Mitral Valve Disease
Interventions: OTHER: prime crystalloid|OTHER: Human Albumin|OTHER: Voluven
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of GLB-001 in Patients With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher Risk Myelodysplastic Syndromes
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: GLB-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycemic Response in Persons With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Balanced Nutritional Drink|OTHER: Diabetes Specific, Balanced Nutritional Drink (DMA)|OTHER: Diabetes Specific, Balanced Nutritional Drink DMB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Geniculate Artery Embolization for Knee Pain Secondary to Osteoarthritis (OA)
Status: COMPLETED
Conditions: Osteo Arthritis Knee
Interventions: DEVICE: Geniculate Artery Embolization|DIAGNOSTIC_TEST: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety, Tolerability, and Pharmacokinetics of LV232 Capsules in Chinese Healthy Volunteers
Status: RECRUITING
Conditions: Healthy Subjects
Interventions: DRUG: LV232|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Utilising AI Analysis of Sounds To prEdict heaRt failurE decOmpensation
Status: NOT_YET_RECRUITING
Conditions: Heart Failure
Interventions: OTHER: Height, weight, and BMI|OTHER: Medical history|OTHER: Physical examination|DIAGNOSTIC_TEST: Venous blood samples|OTHER: Resting vital signs|DIAGNOSTIC_TEST: Transthoracic echocardiogram|OTHER: Sound recordings|DIAGNOSTIC_TEST: Lung ultrasound|OTHER: KCCQ questionnaire|OTHER: ASCEND-HF score|OTHER: Composite Everest congestion score|DIAGNOSTIC_TEST: Bio impedance and total body water measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transcranial Magnetic Stimulation on Somtosensory Cortex Enhances Motor Learning in People With Stroke
Status: RECRUITING
Conditions: Transcranial Magnetic Stimulation|Stroke|Motor Learning
Interventions: DEVICE: repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Combination Therapy of D07001-Softgel Capsules and Xeloda/TS-1 in Subjects With Advanced Biliary Tract Cancer
Status: RECRUITING
Conditions: Biliary Tract Cancer
Interventions: DRUG: D07001-softgel capsules + Xeloda (or TS-1)|DRUG: mFOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Training Balance, or Enjoying Music, Improve Attention, Problem-solving and/or Behavior Control Abilities?
Status: RECRUITING
Conditions: Executive Functions|Postural Balance
Interventions: OTHER: Balance Training|OTHER: Music Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Left Main Coronary Artery Stenosis and Angioplasty With Taxus Stent
Status: COMPLETED
Conditions: Coronary Arteriosclerosis
Interventions: DEVICE: Percutaneous coronary intervention with Taxus stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Treatment With Biological Agents on Vascular and Cardiac Function in Psoriasis
Status: RECRUITING
Conditions: Psoriasis
Interventions: DRUG: etanercept|DRUG: ustekinumab|DRUG: cyclosporine|DRUG: Secukinumab|DRUG: Apremilast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Post-stroke Neural Plasticity With Atomoxetine
Status: COMPLETED
Conditions: Atomoxetine Hydrochloride|Placebos
Interventions: DRUG: Atomoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sugammadex Versus Neostigmine for Reversal of Rocuronium Neuromuscular
Status: COMPLETED
Conditions: Neuromuscular Blockade|Anesthesia
Interventions: DRUG: Neostigmine|DRUG: Glycopyrrolate|DRUG: Sugammadex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Osseodensification by Densah Burs Versus Osteotome
Status: UNKNOWN
Conditions: Maxillary Sinus Lift
Interventions: PROCEDURE: oseodensification sinus lifting|PROCEDURE: osteotome sinus lifting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Three Weeks of Cast Immobilisation Versus One Week of Brace Immobilisation in Distal Radius Fractures
Status: NOT_YET_RECRUITING
Conditions: Distal Radius Fractures|Fractures, Bone
Interventions: OTHER: Cast 3 weeks|OTHER: Brace 1 week
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Diabetic Peripheral Neuropathic Pain
Status: TERMINATED
Conditions: Diabetic Peripheral Neuropathic Pain
Interventions: DRUG: LY3556050|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Myotonia - Lamotrigine Versus Namuscla
Status: RECRUITING
Conditions: Non-Dystrophic Myotonia
Interventions: DRUG: Lamotrigine|DRUG: Namuscla
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral Effects of Drugs Inpatient 44 Neurobehavioral Mechanisms of Opioid Choice
Status: RECRUITING
Conditions: Opioid Use Disorder
Interventions: BEHAVIORAL: Drug Cue|BEHAVIORAL: Money|DRUG: Withdrawal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination of Fedratinib and Decitabine for Myeloproliferative Neoplasms (MPN)- Accelerated Phase (AP)/Blast Phase (BP)
Status: TERMINATED
Conditions: Myeloproliferative Neoplasm
Interventions: DRUG: Fedratinib Oral Capsule 300 mg|DRUG: Decitabine 20 mg/m2|DRUG: Fedratinib Oral Capsule 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erasme Randomized Controlled Trial Surveys Hemodynamic Excursions During Esophagectomy
Status: NOT_YET_RECRUITING
Conditions: Esophagectomy|Epidural; Anesthesia|Paravertebral Anesthesia|Hemodynamic Instability
Interventions: OTHER: Hemodynamic changes between epidural and paravertebral during esophagectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Sapacitabine in Acute Myeloid Leukemia (AML) or Myelodysplastic Syndromes (MDS)
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: sapacitabine and decitabine (Part 1 - completed)|DRUG: sapacitabine and venetoclax (Part 2 - recruiting)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Adaptations to Resistance Exercise: Effect of Set Configuration on Postmenopausal Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Postmenopausal|Hypertension
Interventions: OTHER: Short set configuration resistance training|OTHER: Long set configuration resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NATIENS: Optimal Management and Mechanisms of SJS/TEN
Status: RECRUITING
Conditions: Stevens-Johnson Syndrome|Toxic Epidermal Necrolyses
Interventions: DRUG: Harmonized supportive care|DRUG: Cyclosporine 5 mg/kg bid days 0-14|DRUG: Etanercept 50 mg sc day 0 and day 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Lumbopelvic Massage and Exercise Training in Children With Lower Urinary Tract Dysfunction
Status: NOT_YET_RECRUITING
Conditions: Lower Urinary Tract Symptoms
Interventions: OTHER: Lumbopelvic Massage|OTHER: Exercise Training|DEVICE: Pelvic Floor Electromyography (EMG) Biofeedback Therapy|BEHAVIORAL: Standard Urotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Etanercept: Single Blind Control Study in Ocular Manifestations of Behcet's Disease
Status: UNKNOWN
Conditions: Behcet Syndrome|Uveal Disease
Interventions: DRUG: Etanercept, Methotrexate, Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Ataluren in ≥2 to <5 Year-Old Male Participants With Duchenne Muscular Dystrophy
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: Ataluren
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Adalimumab in Patients With Active Uveitis
Status: COMPLETED
Conditions: Uveitis
Interventions: BIOLOGICAL: Adalimumab|DRUG: Prednisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Growth and Metabolism in Infants Fed Protein-reduced, Alpha-lactalbumin Enriched Formula
Status: ACTIVE_NOT_RECRUITING
Conditions: Growth|Infection|Sleep
Interventions: DIETARY_SUPPLEMENT: Protein-reduced α-lactalbumin formula|DIETARY_SUPPLEMENT: Protein-reduced whey formula|DIETARY_SUPPLEMENT: Standard infant formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Medical-economic Evaluation Comparing Intensive Outpatient Monitoring of Neuro-cardiovascular Diseases by Nurses, Doctors and Hospital and Private-sector Pharmacists, Compared to Usual Monitoring.
Status: RECRUITING
Conditions: Cerebrovascular Accidents|Myocardial Infarction
Interventions: OTHER: Usual follow-up|OTHER: Intensive follow-up
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: NT-814: Evaluation of Its Ability to Alter the Abuse Liability of Oxycodone in an Exploratory Clinical Study
Status: WITHDRAWN
Conditions: Opioid Use Disorder
Interventions: DRUG: Placebo|DRUG: NT-814 50 mg|DRUG: NT-814 100 mg|DRUG: NT-814 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intensity-Modulated Radiation Therapy and Gemcitabine in Treating Patients With Locally Advanced Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: gemcitabine hydrochloride|RADIATION: intensity-modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 in Baselland: Validation of Simple and Accurate Tests for COVID-19 Detection, Monitoring and Tracing (ACCURATE-BL-COVID-19)
Status: RECRUITING
Conditions: Coronavirus Infectious Disease 2019 (COVID-19)
Interventions: OTHER: Saliva based assay: crude RNA extraction|OTHER: Validation of the NGS method|OTHER: Validation of the LAMP assays|OTHER: Validation of the POCT Antigen and Antibody tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Regular Consumption of Micronutrient Fortified Beverage on the Micronutrient Status of Indian Schoolchildren
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Non-Fortified Control Product|OTHER: Micronutrient Fortified Test Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies
Status: NOT_YET_RECRUITING
Conditions: Hematologic Malignancy|Bone Marrow Transplant Rejection|Acute Myeloid Leukemia (AML)|Myelodysplastic Syndromes (MDS)|Acute Lymphoblastic Leukemia (ALL), Adult|Multiple Myeloma|Aplastic Anemia|Lymphoma|Non Hodgkin Lymphoma|Hodgkin Lymphoma|Chronic Myeloid Leukemia|Myelofibrosis
Interventions: DRUG: Darzalex Faspro (Daratumumab and hyaluronidase-fihj)|DEVICE: JH-DSA Semi-Quant Screen and Response Score
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crystalloid Fluids and Cardiac Surgery
Status: SUSPENDED
Conditions: Surgery-Complications
Interventions: PROCEDURE: Normal Saline for fluid resuscitation|PROCEDURE: PlasmaLyte for fluid resuscitation|PROCEDURE: Ringer's Lacatate for fluid resusciation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multi Strain Probiotic Preparation in Patients With Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Diarrhea|Effects of Probiotics
Interventions: DIETARY_SUPPLEMENT: Multi-strain probiotic mixture of four Bifidobacterium, five Lactobacillus and one Streptococcus species or placebo|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Treating Patients With Metastatic Castration Resistant Prostate Cancer Previously Treated With Enzalutamide
Status: ACTIVE_NOT_RECRUITING
Conditions: Castration-Resistant Prostate Carcinoma|Hormone-Resistant Prostate Cancer|PSA Progression|Recurrent Prostate Carcinoma|Stage IV Prostate Adenocarcinoma Cancer AJCC v8
Interventions: DRUG: Enzalutamide|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of a Fixed-dose Combination (FDC) of Dolutegravir (DTG) and Rilpivirine (RPV)
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus|HIV Infections
Interventions: DRUG: DTG|DRUG: RPV|DRUG: DTG/RPV FDC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of Oral Hydroxychloroquine, Indomethacin and Zithromax in Subjects With Mild Symptoms of COVID-19
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Hydroxychloroquine|DRUG: Indomethacin|DRUG: Zithromax Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Versus Late Initiation of Direct Oral Anticoagulants in Post-ischaemic Stroke Patients With Atrial fibrillatioN (ELAN): an International, Multicentre, Randomised-controlled, Two-arm, Assessor-blinded Trial
Status: COMPLETED
Conditions: Ischaemic Stroke
Interventions: DRUG: Early treatment with Rivaroxaban (Xarelto®), Dabigatran (Pradaxa®), Apixaban (Eliquis®) or Edoxaban (Lixiana®)|DRUG: Late treatment with Rivaroxaban (Xarelto®), Dabigatran (Pradaxa®), Apixaban (Eliquis®) or Edoxaban (Lixiana®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nitazoxanide Versus Placebo for the Treatment of Hospitalized Subjects With Severe Acute Respiratory Illness
Status: COMPLETED
Conditions: Severe Acute Respiratory Illness
Interventions: DRUG: Nitazoxanide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimization of Prime Fluid Strategy to Preserve Microcirculatory Perfusion During Cardiac Surgery With Cardiopulmonary Bypass, Part I
Status: RECRUITING
Conditions: Endothelial Dysfunction|Hemolysis|Fluid Overload
Interventions: COMBINATION_PRODUCT: A: gelofusine + ringers|COMBINATION_PRODUCT: B: albumine + ringers|COMBINATION_PRODUCT: C: ringers + retrograde autologous priming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Donepezil, Residual Excessive Daytime Sleepiness, Obstructive Sleep Apnea
Status: UNKNOWN
Conditions: OSA|Sleepiness
Interventions: DRUG: donepezil treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Contrast-enhanced Spectral Mammography (CESM) Breast Cancer Screening
Status: RECRUITING
Conditions: Mammographic Breast Density|Mammography
Interventions: DEVICE: Contrast-enhanced spectral mammography (CESM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Anti-inflammatory Status in DM2 Treated Patients
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Metformin / alogliptin Oral Product|DRUG: Metformin / Pioglitazone Pill|DRUG: triple therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: One Pass Tirofiban In Management of Ischemic Stroke Thrombectomy In China
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: Intravenous tirofiban combination therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of DA-6034 Eye Drops in Dry Eye Syndrome
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: DA-6034 3%|DRUG: DA-6034 5%|DRUG: DA-6034 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exemestane With or Without ATN-224 in Treating Postmenopausal Women With Recurrent or Advanced Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: SOD1 inhibitor ATN-224|DRUG: exemestane|GENETIC: protein expression analysis|GENETIC: proteomic profiling|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate CERC-002 in Adults With COVID-19 Pneumonia and Acute Lung Injury
Status: COMPLETED
Conditions: COVID-19 Pneumonia|Acute Lung Injury|ARDS
Interventions: DRUG: CERC-002|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Thoraco-lumbo-sacral Orthoses (TLSOs) in the Treatment of Adolescent Idiopathic Scoliosis (AIS)
Status: TERMINATED
Conditions: Scoliosis
Interventions: DEVICE: Thoraco-lumbo-sacral Orthosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Understanding and Treating Substance Use Disorder and Comorbid Conditions in Veterans' Real-Life Settings
Status: NOT_YET_RECRUITING
Conditions: Substance Use Disorder
Interventions: BEHAVIORAL: Personal Causal Model + Personalized Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Capecitabine (Xeloda®) in Patients With Locally Advanced or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: capecitabine (Xeloda®)|DRUG: docetaxel (Taxotere®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Respiratory Muscle Dysfunction in Critically Ill Patients
Status: UNKNOWN
Conditions: Sepsis|Mechanical Ventilation
Interventions: PROCEDURE: diaphragm muscle biopsy|PROCEDURE: Diaphragm muscle biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long-Term Immune Persistence of GlaxoSmithKline Biologicals' Inactivated Hepatitis A Vaccine, Injected According to 0, 6-month Schedule
Status: COMPLETED
Conditions: Hepatitis A
Interventions: BIOLOGICAL: Havrix™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Randomized Comparison of Continuous and Intermittent Heparin Infusion During Catheter Ablation of Atrial Fibrillation
Status: COMPLETED
Conditions: Coagulation; Intravascular
Interventions: DRUG: Continuous heparin infusion|DRUG: Intermittent heparin infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Respiratory Exercises on Abdominal Distension in Laparoscopic Cholecystectomy Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Elective Laparoscopic Cholecystectomy
Interventions: OTHER: Respiratory exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate a New Way to Identify/Diagnose Tumours With Somatostatin Receptors Using [68]Ga-HA-DOTATATE and to Ensure it is Safe to Use
Status: RECRUITING
Conditions: Neuroendocrine Tumors
Interventions: DRUG: [68]Ga-HA-DOTATATE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy Study of NP001 in Patients With Amyotrophic Lateral Sclerosis (ALS) and Systemic Inflammation
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: NP001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Frequency of Hypoglycaemic Episodes During Treatment With Insulin Detemir in Well Controlled Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin detemir|DRUG: insulin NPH|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Erector Spinae Muscle in Different Position and the Change After Receiving Myofascial Release.
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: manual erector spinae myofascial realease|OTHER: self-myofascial release technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Vitamin A on RAR Gene Expression in Multiple Sclerosis
Status: UNKNOWN
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: Dietary Supplement: vitamin A|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quantitative Fluorescence Angiography With ICG for Perfusion Assessment During Surgery
Status: RECRUITING
Conditions: Esophagus; Fistula|Fistula;Rectal|Complication of Surgical Procedure|Complication,Postoperative
Interventions: DEVICE: SPY Portable Handheld Imaging (SPY-PHI) System with SPY-QP Software
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Single-dose Study to Investigate the Effects of 4 Different Doses of Inhaled AZD8683 in Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease|COPD
Interventions: DRUG: AZD8683|DRUG: Placebo|DRUG: Tiotropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of PER977 Administered to Subjects With Steady State Edoxaban Dosing and Re-anticoagulation With Edoxaban
Status: COMPLETED
Conditions: Anticoagulation Reversal
Interventions: DRUG: PER977|DRUG: Placebo|DRUG: Edoxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Trial to Determine the Safety of Oral Ifetroban in Patients With a History of Aspirin Exacerbated Respiratory Disease
Status: COMPLETED
Conditions: Aspirin Exacerbated Respiratory Disease (AERD)
Interventions: DRUG: Ifetroban, Oral Capsule|DRUG: Placebo, Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy and Safety of OCS-01 Eye Drops in Subjects With Diabetic Macular Edema (DIAMOND-2)
Status: RECRUITING
Conditions: Diabetic Macular Edema
Interventions: DRUG: Dexamethasone ophthalmic suspension (OCS-01)|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PreFem: "What Happens to the Vaginal Microbiota When a BV Infection is Treated With Metronidazole?"
Status: COMPLETED
Conditions: Bacterial Vaginosis
Interventions: OTHER: Metronidazole|OTHER: Control: no treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effects of Aromatherapy on Pain, Sleep Quality, and Psychological Distress in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BEHAVIORAL: aromatherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Detection of Circulating Tumor Cells (CTCs) in Patients With Breast Cancer Undergoing Cryosurgery Combined With DC-CIK Treatment
Status: COMPLETED
Conditions: Neoplastic Cells, Circulating
Interventions: OTHER: Flow cytometry (FCM)|OTHER: RT-PCR
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Real-world Resource Use and Costs of CAR-T Therapies in Diffuse Large B-cell Lymphoma (DLBCL)
Status: COMPLETED
Conditions: Diffuse Large B-cell Lymphoma (DLBCL)
Interventions: OTHER: CAR-T|OTHER: Allo-HSCT cohort
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison Between Two Concentration of Hypertonic Saline in Intestinal Obstruction Surgery
Status: UNKNOWN
Conditions: Intestinal Obstruction Fluid Management With Hypertonic Saline
Interventions: DRUG: Hypertonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Artemisia Pollen Specific Allergen Immunotherapy
Status: RECRUITING
Conditions: Allergic Rhinitis
Interventions: DRUG: AIT drops|DRUG: Clarityne, Rhinocort and Emedastine Difumarate Eye Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravesical Instillation of Liposome Encapsulated Botulinum Toxin A (Lipotoxin) in Treatment of Interstitial Cystitis
Status: COMPLETED
Conditions: Interstitial Cystitis
Interventions: DRUG: Liposome encapsulated BoNT-A|DRUG: BOTOX 200U in normal saline|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transcoronary Infusion of Cardiac Progenitor Cells in Patients With Single Ventricle Physiology
Status: COMPLETED
Conditions: Hypoplastic Left Heart Syndrome|Single Ventricle|Heart Failure
Interventions: PROCEDURE: Autologous cardiac progenitor cell transplantation|PROCEDURE: staged shunt procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT