pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparing Air Embolic Load in Two Venous Cannulation Methods, 40 Patients Undergoing Elective Valve Surgery.
Status: COMPLETED
Conditions: Extracorporeal Circulation; Complications|Air Embolism
Interventions: DIAGNOSTIC_TEST: Volume control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: RVT-3101 for the Treatment of Moderate to Severe Active Crohn's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn Disease
Interventions: DRUG: RVT-3101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Value of Bacterial Loads by Real Time PCR in Predicting Recurrence of Abnormal Vaginal Flora After Oral Metronidazole Therapy
Status: COMPLETED
Conditions: Abnormal Vaginal Flora
Interventions: DRUG: Treatment BY METROMIDAZOLE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Lateral Ridge Augmentation Around Implants
Status: UNKNOWN
Conditions: Alveolar Bone Resorption
Interventions: DEVICE: Resorbable Collagen membrane with bone graft for augmentation|DEVICE: Ribose cross linked collagen matrix for augmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impacts of the Covid-19 Epidemic and Associated Lockdown Measures on the Management, Health and Behaviors of Cystic Fibrosis Patients During the 2020 Epidemic
Status: COMPLETED
Conditions: Cystic Fibrosis in Children|Cystic Fibrosis
Interventions: BEHAVIORAL: Questionnaire|BEHAVIORAL: Interview
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunity Duration of Rabies Vaccine and Booster Dose Effects at 10 Years Post-primary Vaccination
Status: COMPLETED
Conditions: Rabies
Interventions: BIOLOGICAL: Chengdu Kanghua (one booster shot)|BIOLOGICAL: Chengdu Kanghua (two booster shots)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Role of Serotonin in Compulsive Behavior in Humans: Underlying Brain Mechanisms
Status: ACTIVE_NOT_RECRUITING
Conditions: Obsessive-Compulsive Disorder/High Compulsive Individuals|Healthy Individuals
Interventions: DRUG: Escitalopram|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Extension Study to a Clinical Study That Will Continue to Evaluate the Effectiveness and Safety of SEP-363856 in People With Schizophrenia That Switch to SEP-363856 From Their From Their Current Antipsychotic Medication
Status: ENROLLING_BY_INVITATION
Conditions: Schizophrenia
Interventions: DRUG: SEP-363856
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SIS Graft and Traditional Repair in Vaginal Wall Prolapse
Status: COMPLETED
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: Traditional correction of anterior vaginal wall prolapse|PROCEDURE: Biologic Graft (SIS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Clinical Trial to Evaluate the Efficacy and Safety of Neurotropic B-Vitamins in Clinically Diagnosed Peripheral Sensory Polyneuropathy of Different Etiologies.
Status: COMPLETED
Conditions: Peripheral Sensory Neuropathy of Different Etiologies
Interventions: DRUG: Vitamin B combination tablet|DRUG: Placebo Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Core Stabilization and Strengthening Exercise on Quality of Life in Clinical Lumbar Instability
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: OTHER: Core Stabilization Exercise|OTHER: General Strengthening Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy, Interleukin-2, and Peripheral Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Leukemia
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: filgrastim|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: etoposide|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy of Virtual Reality on Balance in Children With Ataxic Cerebral Palsy Randomized Controlled Trail
Status: COMPLETED
Conditions: Ataxic Cerebral Palsy
Interventions: DEVICE: virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lactate Metabolism Study in HIV Infected Persons
Status: COMPLETED
Conditions: HIV Infections|AIDS|Lactic Acidosis|Lipodystrophy
Interventions: DRUG: cofactor supplementation (thiamine, riboflavin, L-carnitine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Tele-health Enabled Clinical Trial for COVID-19
Status: WITHDRAWN
Conditions: SARS-CoV Infection
Interventions: DRUG: Vitamin D3 or Placebo|DEVICE: Doctella telehealth monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiorespiratory Responses to Exercise in Elderly
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Hypertension
Interventions: DIAGNOSTIC_TEST: Cardiopulmonary Exercise Test Protocol|DIAGNOSTIC_TEST: Polysomnography Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: The Use of Incentives to Promote Healthier Eating in Low-income Communities
Status: COMPLETED
Conditions: Focus of the Study is on the Use of Incentives to Promote|Healthier Eating in Low-income Communities
Interventions: BEHAVIORAL: Fruit and vegetable rewards
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effects of Perioperative B&O Suppositories on Post-op Pain and Morphine Use After Laparoscopic Prostatectomy
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: belladonna 16.2 mg and opium 60 mg suppository
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine Safety, Tolerability, and Pharmacokinetics of Different Orally Administered Regimens of the Combination ZY19489-Ferroquine in Adult Asymptomatic Plasmodium Falciparum Carriers
Status: NOT_YET_RECRUITING
Conditions: Uncomplicated Malaria|Asymptomatic Condition|Falciparum Malaria
Interventions: DRUG: ZY19489 + Ferroquine (FQ)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effectiveness of Juvéderm® VOLIFT™ With Lidocaine for Lip Augmentation
Status: COMPLETED
Conditions: Lip Augmentation
Interventions: DEVICE: Juvéderm® VOLIFT™ with Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Trial to Explore the Tolerability, Safety and Efficacy of Paliperidone Extended Release in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Paliperidone ER
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of a Drug to be Used in Addition With Another Drug to Treat Adults With Uncontrolled Partial-onset Seizures
Status: COMPLETED
Conditions: Epilepsy With Partial On-set Seizures
Interventions: DRUG: Eslicarbazepine acetate|DRUG: Eslicarbazepine Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Value Increase of Egg Products
Status: COMPLETED
Conditions: Healthy|Inflammation|Aging
Interventions: OTHER: Eggshell membrane (ESM)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Benefits of Posterior Joint Infiltration in Chronic Low Back Pain
Status: NOT_YET_RECRUITING
Conditions: Chronic Low-back Pain
Interventions: PROCEDURE: echo-guided infiltration|PROCEDURE: non-echo-guided infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RICE-ibrutinib in Relapsed DLBCL
Status: UNKNOWN
Conditions: Diffuse Large B Cell Lymphoma|Diffuse Large B-Cell Lymphoma Recurrent
Interventions: DRUG: Ibrutinib-RICE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tislelizumab and Nab-paclitaxel Combined With Low-dose Radiotherapy in Patients With Stage IVb Esophageal Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: ESCC
Interventions: DRUG: Tislelizumab combined with chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Mindfulness-based Intervention as a Workplace Health Promotion Program on Weight Loss
Status: UNKNOWN
Conditions: Mindfulness|Weight Loss|Workplace|Health Promotion
Interventions: BEHAVIORAL: Mindfulness-based Intervention|BEHAVIORAL: Health Education Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigation of Pain During Subcutaneous Injections With Different Injection Speed and Volume Combinations
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2|Delivery Systems
Interventions: OTHER: 19 injections|DRUG: sodium chloride 0.9% solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preventing Smoking Relapse After Total Joint Replacement Surgery
Status: COMPLETED
Conditions: Smoking|Smoking Cessation
Interventions: BEHAVIORAL: Comprehensive Relapse Prevention Intervention|BEHAVIORAL: Standard Treatment Counseling|DRUG: Nicotine Replacement Therapy (NRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Non-invasive Urinary Collection Technique for the Adaptation of Diuretic Treatment in Incontinent Heart Failure Patient Over 75 Years of Age in the Acute Phase
Status: RECRUITING
Conditions: Diuresis in Incontinent Patients
Interventions: OTHER: carrying out standard care|OTHER: adult diaper
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nutritional Trial With Probiotic Fortified Milk in Women Affected by Insomnia
Status: COMPLETED
Conditions: Sleep Disorders
Interventions: DIETARY_SUPPLEMENT: Fortified milk|DIETARY_SUPPLEMENT: Placebo milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GS-5829 (Alobresib) as a Single Agent and In Combination With Enzalutamide in Participants With Metastatic Castrate-Resistant Prostate Cancer
Status: TERMINATED
Conditions: Metastatic Castrate-Resistant Prostate Cancer
Interventions: DRUG: Alobresib|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contribution of Learning and Practice of Different Complementary Therapies in Pulmonary Transplant Patients
Status: COMPLETED
Conditions: Lung Transplant
Interventions: BEHAVIORAL: Relaxation|BEHAVIORAL: Hypnosis|BEHAVIORAL: Holistic gymnastics|DEVICE: Transcutaneous electrical nerve stimulation (TENS)|BEHAVIORAL: Sophrology
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity Study of QIVc in Healthy Pediatric Subjects
Status: COMPLETED
Conditions: Influenza|Human|Virus Diseases
Interventions: BIOLOGICAL: QIVc|BIOLOGICAL: Comparator QIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Single-centre, Randomised, Double-blind, Placebo-controlled, Four-way Crossover Clinical Study to Investigate Safety and Tolerability and Pharmacokinetics of Single Doses of CM3.1-AC100 in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type II Diabetes Mellitus
Interventions: DRUG: CM3.1-AC100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Look at How Safe a New Medicine (NNC0491-6075) is in Healthy People and in Participants With High Levels of Fat in the Blood
Status: RECRUITING
Conditions: Healthy Volunteers|Dyslipidaemia
Interventions: DRUG: NNC0491-6075|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 562 in Subjects With r/r Diffuse Large B-cell Lymphoma, Mantle Cell Lymphoma, or Follicular Lymphoma
Status: TERMINATED
Conditions: Diffuse Large B-cell Lymphoma(DLBCL)|Mantle Cell Lymphoma (MCL)|Follicular Lymphoma (FL)
Interventions: DRUG: AMG 562
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Investigate Safety and Tolerability of ASP7962 in Healthy Humans
Status: COMPLETED
Conditions: Safety|Tolerability|Pharmacokinetics of ASP7962
Interventions: DRUG: ASP7962|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cognitive Processing Therapy vs. Sertraline for the Treatment of PTSD & SUD in Egyptian Patients
Status: COMPLETED
Conditions: Psychologic Manipulation
Interventions: BEHAVIORAL: Cognitive processing therapy|DRUG: Sertraline|OTHER: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Insulin Glargine in Type I Diabetes Mellitus> Main Study "AT.LANTUS": A Trial Comparing Lantus Algorithms to Achieve Normal Blood Glucose Targets in Subjects With Uncontrolled Blood Sugar. Sub-study: "HALT"(Hypoglycaemia Avoidance With Lantus Trial)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Insulin Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Perineural Dexamethasone and Systemic Dexamethasone in PENG Block
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain, Acute|Postoperative Pain|Hip Fractures
Interventions: DRUG: Group P|DRUG: Group S
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Abdominal Functional Electrical Stimulation to Reduce Hyperinflation in Chronic Obstructive Pulmonary Disease Patients
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DEVICE: Abdominal Stimulation - low / early|DEVICE: Abdominal stimulation - low/late|DEVICE: Abdominal Stimulation - low/full|DEVICE: Abdominal stimulation - med/early|DEVICE: Abdominal stimulation - med/late|DEVICE: Abdominal Stimulation - med/full|DEVICE: Abdominal Stimulation - high/early|DEVICE: Abdominal Stimulation - high/late|DEVICE: Abdominal Stimulation - high/full
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: The Phase IVa of Inactivated Enterovirus 71 Vaccine (Human Diploid Cell, KMB-17)
Status: UNKNOWN
Conditions: Safety of Inactivated EV71 Vaccine|Immunization of Inactivated EV71 Vaccine
Interventions: BIOLOGICAL: inactivated EV71 vaccine (KMB-17)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Survival Study for Women With Advanced Lung Cancer Who Have Not Previously Received Chemotherapy.
Status: TERMINATED
Conditions: NSCLC
Interventions: DRUG: paclitaxel|DRUG: paclitaxel poliglumex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CS02 vs Placebo With Metformin in Type 2 Diabetes Mellitus (T2DM)
Status: COMPLETED
Conditions: T2DM With Inadequate Glycemic Control
Interventions: DRUG: CS02 tablet and placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-centre Study to Evaluate ACAF Versus Laminoplasty in Treating Cervical Ossification of the Posterior Longitudinal Ligament
Status: RECRUITING
Conditions: Ossification of Posterior Longitudinal Ligament|Cervical Spondylosis With Myelopathy
Interventions: PROCEDURE: ACAF|PROCEDURE: Laminoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma
Status: RECRUITING
Conditions: Unresectable Pleural Mesothelioma
Interventions: DRUG: Volrustomig|DRUG: Pemetrexed|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of NN1250 Plus Insulin Aspart With Insulin Glargine Plus Insulin Aspart in Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin degludec|DRUG: insulin glargine|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correction of Myopia Wtih or Without Astigmatism Using the VisuMax™ Femtosecond Laser
Status: COMPLETED
Conditions: Myopia|Astigmatism
Interventions: DEVICE: Carl Zeiss Meditec VisuMax Femtosecond Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Forest Therapy on Physical and Psychological Parameters in the General Population - a Randomized Controlled Trial
Status: RECRUITING
Conditions: General Population (no Specific Condition or Disease)
Interventions: BEHAVIORAL: Active forest therapy|BEHAVIORAL: Passive forest therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Peptide Receptor Radionuclide Therapy in the Treatment of Advanced, Non-resectable and/or Symptomatic Tumors With SSTR Overexpression
Status: UNKNOWN
Conditions: Neuroendocrine Tumors
Interventions: DRUG: 90Y-DOTATATE|DRUG: (177Lu-DOTAOTyr3)Octreotate|DRUG: 90Y DOTATATE and 177Lu DOTATATE (mix each of 50%)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regular Home-use Dual Light Photodynamic Therapy in the Prevention of Osteolysis After Dental Implant Surgery
Status: NOT_YET_RECRUITING
Conditions: Osteolysis|Dental Implants
Interventions: DEVICE: Lumoral Treatment|OTHER: Standard oral hygiene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Viokase 16, Viokase16 Plus Nexium and Nexium Alone
Status: TERMINATED
Conditions: Chronic Pancreatitis
Interventions: DRUG: Nexium (esomeprazole magnesium)|DRUG: Placebo to Nexium|DRUG: Viokase 16 (pancrelipase) + Nexium|DRUG: Viokase 16 + placebo to Nexium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Efficacy and Safety of CWP-0403 in Type 2 Diabetes Mellitus Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Anagliptin|DRUG: Anagliptin|DRUG: Placebo of Anagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Tolerability of a Therapeutic Vaccine, ASP0113, in Subjects Undergoing Allogeneic Hematopoietic Cell Transplant
Status: COMPLETED
Conditions: Allogeneic Hematopoietic Cell Transplant
Interventions: BIOLOGICAL: ASP0113
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A RCT Comparing Dronabinol to a Placebo for Post-operative Pain in Total Joint Arthroplasty
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Dronabinol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Surufatinib Combined With Tislelizumab in the Second-line and Further Treatment of Triple-negative Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Metastatic Triple-negative Breast Cancer
Interventions: DRUG: Surufatinib|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Research Study Utilizing Expanded Multi-antigen Specific Lymphocytes for the Treatment of Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumors
Interventions: BIOLOGICAL: Tumor associated antigen lymphocytes (TAA-CTL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Do Combinatorial Training Lead to Better Cognition and Daily Participation in TBI Persons With Cognitive Impairments
Status: UNKNOWN
Conditions: Trauma, Brain|Cognitive Deficit
Interventions: PROCEDURE: aerobic exercise training|PROCEDURE: computerized cognitive training|PROCEDURE: guiding training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Role of Polyunsaturated Fatty Acids (PUFA)-Gene Interactions in Heath Disparities
Status: COMPLETED
Conditions: Fatty Acid-Gene Interactions
Interventions: DIETARY_SUPPLEMENT: High Linoleic Acid (LA) Diet|DIETARY_SUPPLEMENT: Low Linoleic Acid (LA) Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nasal Septum Perforation Treatment Using Tissue Engineered Cartilage Graft
Status: COMPLETED
Conditions: Nasal Cartilage Septum Perforations
Interventions: BIOLOGICAL: N-TEC: Autologous nasal chondrocytes and ECM proteins
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tele-education in Ultrasound Training
Status: RECRUITING
Conditions: Telemedicine|Ultrasonography|Education, Medical, Continuing
Interventions: DEVICE: Head-Mounted Display (HMD) to communicate with a supervisor remotely
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Attachment, Regulation and Competency (ARC) Framework
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder|Developmental Trauma Disorder
Interventions: BEHAVIORAL: Attachment Regulation and Competency|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-Myeloablative HLA-Matched Ex-Vivo T-cell Depleted Stem Cell Transplantation for Hematologic Malignancies
Status: TERMINATED
Conditions: Lymphoma|Leukemia|Multiple Myeloma|Myelodysplastic Syndrome
Interventions: PROCEDURE: Non-myeloablative Ex-Vivo T-cell Depleted PBSC Transplant|PROCEDURE: T-cell depleted peripheral blood stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - S3 Intermediate
Status: ACTIVE_NOT_RECRUITING
Conditions: Symptomatic Severe Aortic Stenosis
Interventions: DEVICE: TAVR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery
Status: COMPLETED
Conditions: Hypotension|Postoperative Complications|Acute Coronary Syndrome|Heart Failure|Coronary Occlusion|Stroke|Acute Kidney Injury|Renal Insufficiency, Chronic|Death
Interventions: DRUG: Liberal blood pressure management|DRUG: Tight blood pressure management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Study of Paliperidone Extended-Release Tablets in the Treatment of Methamphetamine Dependence
Status: COMPLETED
Conditions: Methamphetamine Dependence
Interventions: DRUG: Paliperidone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Families First Edmonton (FFE)
Status: COMPLETED
Conditions: Low-Income Population
Interventions: BEHAVIORAL: Primary Health Care Model (PRMHLTH)|BEHAVIORAL: Recreation Coordination Model (REC)|BEHAVIORAL: Comprehensive Model (COMP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: TDF Combined With LDT for the Treatment of HBeAg-positive Hepatitis B Patients With Poor Response to TDF for 12 Months
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: TDF|DRUG: Tenofovir Disoproxil Fumarate 300 MG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Parenting Young Children in Pediatrics
Status: RECRUITING
Conditions: Parenting|Parent-Child Relations|Substance Use Disorders|Stress|Depression|Anxiety|Parenting Self-efficacy|Pediatrics
Interventions: BEHAVIORAL: Family Check-Up Online
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Adjunctive Clindamycin for Cellulitis: C4C Trial.
Status: COMPLETED
Conditions: Cellulitis
Interventions: DRUG: Flucloxacillin|DRUG: Clindamycin|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Clinical Outcome of 2 Different Total Knee Prostheses: Nexgen LPS-Flex Versus AGC
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Nexgen LPS-flex and AGC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of the CD38 Antibody Daratumumab in Patients With High-Risk MGUS and Low-Risk Smoldering Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Monoclonal Gammopathy|Smoldering Multiple Myeloma
Interventions: DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Different Methods of Airway Management on the Stomatognathic System: an Observational Prospective Study.
Status: RECRUITING
Conditions: Airway Management|Endotracheal Intubation|Supraglottic Airway Device|Regional Anesthesia
Interventions: OTHER: Airway management techniques (exposure)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: High Dose Bupropion for Smoking Cessation - Pilot Study
Status: TERMINATED
Conditions: Smoking Cessation|Smoking, Tobacco|Smoking (Tobacco) Addiction|Cessation, Tobacco|Cigarette Smoking
Interventions: DRUG: Bupropion Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cryopreserved MMUD BM With PTCy for Hematologic Malignancies
Status: WITHDRAWN
Conditions: Acute Leukemia|Myelodysplastic Syndromes|T-lymphoblastic Lymphoma|Acute Lymphocytic Leukemia|Acute Myeloid Leukemia|Acute Biphenotypic Leukemia|Acute Undifferentiated Leukemia
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|RADIATION: Total Body Irradiation|DRUG: Busulfan|DRUG: Mesna|DRUG: Sirolimus|DRUG: Mycophenolate Mofetil|DRUG: Filgrastim|DRUG: Cyclophosphamide|PROCEDURE: Bone Marrow Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Determine the Effects of Avosentan on Doubling of Serum Creatinine, End Stage Renal Disease and Death in Diabetic Nephropathy
Status: TERMINATED
Conditions: Diabetic Nephropathy
Interventions: DRUG: SPP301
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of MAT9001(Omega-3-pentaenoic Acid) in Subjects With Triglycerides ≥500 mg/dL and <2000 mg/dL
Status: WITHDRAWN
Conditions: Severe Hypertriglyceridemia
Interventions: DRUG: Placebo|DRUG: MAT9001 (omega-3 pentaenoic acid)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IRB 14-009240, Does CEUS Positively Influence Selection of Biopsy Sites When Evaluating Transplant Kidneys?
Status: COMPLETED
Conditions: Transplantation, Kidney
Interventions: DRUG: Optison|DIAGNOSTIC_TEST: Ultrasound (US)|DIAGNOSTIC_TEST: Contrast-enhanced ultrasound (CEUS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase III Study of TY-9591 in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer (FLETEO)
Status: RECRUITING
Conditions: NSCLC|EGFR Activating Mutation
Interventions: DRUG: TY-9591|DRUG: placebo Osimertinib|DRUG: Osimertinib|DRUG: placebo TY-9591
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Classroom-Level Intervention to Promote Peers' Acceptance of Children With Attention Deficit Hyperactivity Disorder (ADHD)
Status: UNKNOWN
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: Behavioral contingency management|BEHAVIORAL: Tolerance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing a New Anti-cancer Drug Combination, Entinostat and GSK525762C, for Advanced and Refractory Solid Tumors and Lymphomas
Status: WITHDRAWN
Conditions: Advanced Lymphoma|Advanced Malignant Solid Neoplasm|Ann Arbor Stage III B-Cell Non-Hodgkin Lymphoma|Ann Arbor Stage III T-Cell Non-Hodgkin Lymphoma|Ann Arbor Stage IV B-Cell Non-Hodgkin Lymphoma|Ann Arbor Stage IV T-Cell Non-Hodgkin Lymphoma|Refractory B-Cell Non-Hodgkin Lymphoma|Refractory Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Pancreatic Carcinoma|Refractory T-Cell Non-Hodgkin Lymphoma|Stage II Pancreatic Cancer AJCC v8|Stage IIA Pancreatic Cancer AJCC v8|Stage IIB Pancreatic Cancer AJCC v8|Stage III Pancreatic Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8|Unresectable Pancreatic Carcinoma
Interventions: DRUG: Entinostat|DRUG: Molibresib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Intravitreal POT-4 Therapy for Patients With Neovascular Age-Related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: POT-4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Results of Cervical Segmental Mobilization in Patients With Chronic Lateral Epicondylitis
Status: RECRUITING
Conditions: Epicondylitis of the Elbow|Servical Segmental Mobilization
Interventions: BEHAVIORAL: mobilization|OTHER: standard treatment|OTHER: deep friction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Real World Efficacy, Safety of Nanoliposomal Irinotecan With Fluorouracil and Folinic Acid in Metastatic Pancreatic Cancer After Previous Gemcitabine-based Therapy
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma Metastatic
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Influence of Analgesia and Neuromuscular Block on Abdominal Distension and Operating Conditions Laparoscopic Operations
Status: COMPLETED
Conditions: Neuromuscular Blockade
Interventions: OTHER: measuring tape|OTHER: neuromuscular block|OTHER: Surgical rating score
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Combination of Panitumumab With Paclitaxel as First-line Treatment of Subjects With Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: Panitumumab + paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial With Rhinitic Patients Taking GSK256066 Versus Placebo In A Pollen Challenge Chamber
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal|Seasonal Allergic Rhinitis
Interventions: DRUG: GSK256066
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Metronidazole Prophylaxis Against Clostridium Difficile-Associated Diarrhea in High Risk Adult Patients
Status: TERMINATED
Conditions: Clostridium Difficile Diarrhea
Interventions: DRUG: Metronidazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: In Vivo Investigation on Mitochondrial Dysfunction in Post-COVID Fatigue and Cancer Fatigue.
Status: RECRUITING
Conditions: Mitochondrial Dysfunction|COVID-19|Fatigue
Interventions: OTHER: MRI/ 3D Arterial Spin Labelling (ASL) and 1H magnetic resonance spectroscopy (MRS)|OTHER: Chalder Fatigue Scale|OTHER: Health Questionnaire (EQ-5D-5L)|OTHER: Hamilton Depression Rating Scale
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Effects of Platelet Rich Fibrin on the Palatal Mucosal Healing
Status: COMPLETED
Conditions: Wound Healing|Pain, Postoperative|Bleeding Wound
Interventions: PROCEDURE: connective tissue graft|PROCEDURE: connective tissue graft&PRF|OTHER: connective tissue graft&PRF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neighborhood Alcohol & HIV Prevention in South African Townships (Philani)
Status: ACTIVE_NOT_RECRUITING
Conditions: Fetal Alcohol Syndrome|HIV|Nutrition Disorders
Interventions: BEHAVIORAL: Philani Intervention Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Three Arm Trial of Immune Effects of Echinacea
Status: COMPLETED
Conditions: Upper Respiratory Tract Infections
Interventions: BIOLOGICAL: Echinacea purpurea product|BIOLOGICAL: Echinacea purpurea product|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Open-Label Study of Telaprevir Administered Every 12 or 8 Hours in Combination With One of Two Pegylated Interferons and Ribavirin in Treatment-Naive Genotype 1 Chronic Hepatitis C Participants
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Telaprevir|DRUG: Peg-IFN-alfa-2a|DRUG: Peg-IFN-alfa-2b|DRUG: Ribavirin (RBV) tablet|DRUG: Ribavirin (RBV) capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0227 Cisplatin With Either Paclitaxel or Gemcitabine in Recurrent, Persistent, or Metastatic Cervical Cancer
Status: WITHDRAWN
Conditions: Cervical Cancer
Interventions: DRUG: cisplatin|DRUG: gemcitabine hydrochloride|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effect of Voxelotor on Cerebral Hemodynamic Response in Children With Sickle Cell Anemia
Status: RECRUITING
Conditions: Sickle Cell Anemia in Children
Interventions: DRUG: Voxelotor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety Study of Mesenchymal Precursor Cells in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Mesenchymal Precursor Cells (MPCs)|DRUG: Mesenchymal Precursor Cells (MPCs)|DRUG: Mesenchymal Precursor Cells (MPCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Possible Improvement in Speech and Hearing Tests After 28 Days of Dosing of the Study Drug AUT00063 Compared to Placebo (QuicKfire)
Status: COMPLETED
Conditions: Hearing Loss|Hearing Impairment
Interventions: DRUG: AUT00063|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Binaural Audition on Postural Performance and Orientation
Status: COMPLETED
Conditions: Unilateral Cochlear Implants|Bilateral Cochlear Implants
Interventions: OTHER: Audio-vestibular examination|OTHER: Videonystagmoscopic study|OTHER: Posturographies study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effectiveness of Transdiagnostic CBT Protocol on Anxiety Disorders
Status: NOT_YET_RECRUITING
Conditions: Anxiety Disorders|Social Anxiety Disorder|Generalized Anxiety Disorder|Panic Disorder|Anxiety Disorder NOS
Interventions: OTHER: Unified Protocol for Anxiety Disorders|OTHER: Client-centered Supportive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: GM-CSF to Decrease ICU Acquired Infections
Status: COMPLETED
Conditions: Septic Shock|Severe Sepsis
Interventions: DRUG: Sargramostim: Leukine (Genzyme USA)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of 2 Oral Doses of PG-760564 in Rheumatoid Arthritis (RA) Patients Receiving Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: PG-760564|DRUG: Placebo dose|DRUG: PG-760564
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: High Fat Diet: Oxidative and Cardiovascular Effects
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: MUFA|DIETARY_SUPPLEMENT: PUFA|DIETARY_SUPPLEMENT: SFA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mitochondrial Cocktail for Gulf War Illness
Status: COMPLETED
Conditions: Gulf War Syndrome|Persian Gulf Syndrome|Mitochondrial Disorders
Interventions: DIETARY_SUPPLEMENT: Individualized mitochondrial cocktail|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: BONE: STAR (Switching to TAF Based Anti-Retroviral Therapy) Study
Status: RECRUITING
Conditions: Bone Loss
Interventions: DRUG: B/F/TAF|DRUG: TDF/3TC/EFV or DTG or NVP|OTHER: DMPA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clarithromycin Plus CTd Regimen for Patients With Newly Diagnosed Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Clarithromycin|DRUG: Thalidomide|DRUG: Cyclophosphamide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resection of the Nerve Plexus on the Right Half of Celiac and SMA Associated With Extended Pancreatoduodenectomy in the Surgical Treatment for Adenocarcinoma of the Head of Pancreas
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: PROCEDURE: resection of the nerve plexus on the right half of celiac and SMA associated with extended pancreatoduodenectomy|PROCEDURE: standard pancreatoduodenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Characterize Atrial Fibrillation in CHF Patients Indicated for CRT
Status: COMPLETED
Conditions: Congestive Heart Failure, Atrial Fibrillation
Interventions: DEVICE: Vitatron biventricular pacemaker
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 2, Open-label Study of AMG 706 to Treat Subjects With Locally Advanced or Metastatic Thyroid Cancer
Status: COMPLETED
Conditions: Thyroid Cancer
Interventions: DRUG: AMG 706
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of Topical LFX453 for External Genital Warts
Status: COMPLETED
Conditions: External Genital Warts
Interventions: DRUG: Investigational Treatment|DRUG: Aldara
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Two Alcohol-free Beers With Different Carbohydrates Composition on Lipids and Glucose Metabolism
Status: UNKNOWN
Conditions: Glucose Metabolism Disorders (Including Diabetes Mellitus)|Overweight and Obesity
Interventions: OTHER: Alcohol-free beer with regular composition|OTHER: Alcohol-free beer with modified composition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving MEDication Adherence in Chronic Heart Failure Using a TELEmedicine Device (TELEMED-HF)
Status: WITHDRAWN
Conditions: Heart Failure
Interventions: BEHAVIORAL: Medication Adherence Support System (MASS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Home Based Treatment for Drug Use in Early Adolescents
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder|Oppositional Defiant Disorder|Conduct Disorder|Substance Abuse
Interventions: BEHAVIORAL: Adolescent Skills Parent Management Parent-Adol Negotiation|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Operative Evaluation of Endodontic Microsurgeries Done Using a Piezoelectric Ultrasonic Technique: An in Vivo Study
Status: COMPLETED
Conditions: Periapical Diseases|Endodontic Overfill|Healing Surgical Wounds
Interventions: PROCEDURE: Piezosurgery assisted group|PROCEDURE: Trephine Bur assisted group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT