pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Multicentral Preventive Antibiotics With Cystectomy Within Enhanced Recovery After Surgery
Status: UNKNOWN
Conditions: Bladder Cancer
Interventions: DRUG: Meropenem 1000 mg|DRUG: Amoxicillin+clavulanic acid 1200 mg or Cefuroksim 1500mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Drug-drug Interaction (DDI) Study to Assess the Effect of INC280 on the Pharmacokinetics of Digoxin and Rosuvastatin in Patients With cMET-dysregulated Advanced Solid Tumors
Status: COMPLETED
Conditions: cMET-dysregulated Advanced Solid Tumors
Interventions: DRUG: INC280|DRUG: digoxin|DRUG: rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Randomized, Placebo-Controlled Phase 2 Study to Evaluate the Clinical Efficacy, Safety, and Tolerability of ARX-F01 Sublingual Sufentanil in Patients Undergoing Elective Unilateral Total Knee Replacement
Status: COMPLETED
Conditions: Post Operative Pain
Interventions: DRUG: Sufentanil NanoTab|DRUG: Placebo NanoTab|DRUG: Sufentanil NanoTab|DRUG: Sufentanil NanoTab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adherence Monitoring System in Managing Myelosuppression in Patients With Newly Diagnosed Malignant Gliomas Receiving Temozolomide and Radiation Therapy
Status: TERMINATED
Conditions: Malignant Glioma|Myelosuppression
Interventions: OTHER: Medical Chart Review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Characteristics and Outcomes of Patients With Pulmonary Hypertension Associated Right Heart Failure
Status: ACTIVE_NOT_RECRUITING
Conditions: Right Heart Failure|Pulmonary Hypertension
Interventions: DIAGNOSTIC_TEST: Echocardiography|DIAGNOSTIC_TEST: Right heart catheterization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Feasibility Study of Combined Kidney and Hematopoietic Stem Cell Transplantation to Cure End-stage Renal Disease
Status: RECRUITING
Conditions: End Stage Renal Disease
Interventions: PROCEDURE: Kidney and hematopoietic stem cell transplantation|BIOLOGICAL: hematopoietic stem cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compassionate Use of Omegaven in the Treatment of Parenteral Nutrition Induced Hepatic Injury
Status: COMPLETED
Conditions: Liver Disease|Impaired Liver Function|Parenteral Nutrition Associated Liver Disease
Interventions: DRUG: Omegaven
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Efficacy and Safety Study of Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva.
Status: COMPLETED
Conditions: Fibrodysplasia Ossificans Progressiva
Interventions: DRUG: Palovarotene
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sore Throat Prevention Following Intubation
Status: COMPLETED
Conditions: Sore Throat
Interventions: DRUG: xylocaine|DRUG: Dexamethasone|DRUG: Xylocaine and Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Stem Cell Analysis, Omics (Including Immunomics) and Artificial Intelligence in Glioblastoma
Status: NOT_YET_RECRUITING
Conditions: Glioblastoma, IDH-wildtype
Interventions: OTHER: Biological biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: EXTENT: EXtended Tolerability and Efficacy of a Novel Formulation of Oxcarbazepine in a Trial in Partial Epilepsy
Status: TERMINATED
Conditions: Partial Epilepsy
Interventions: DRUG: modified release formulation of oxcarbazepine (OXC MR)|DRUG: immediate release formulation of oxcarbazepine (OXC IR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of Biomarkers of Exposure and Host Response
Status: COMPLETED
Conditions: Cigarette Smoker
Interventions: DRUG: nicotine polacrilex|DRUG: nicotine transdermal system|DRUG: nicotine inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Preeclampsia Postpartum Antihypertensive Treatment
Status: RECRUITING
Conditions: Preeclampsia|Hypertension in Pregnancy
Interventions: DRUG: Labetalol, Nifedipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-Cost, Portable Flexible Nasopharyngoscope in Head & Neck Cancers in Low Resource Settings - Optimization Phase
Status: COMPLETED
Conditions: Head and Neck Cancer|Oral Cancer
Interventions: DEVICE: Nasopharyngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Obstetrics and Gynecology Residents and Experts' Knowledge of, Attitudes Toward, Practice Behaviors, and Self-confidence Levels of Caring for Lesbian, Bisexual, and Transgender (LBT+) Patients in Turkey; A Descriptive-cross Sectional Study
Status: COMPLETED
Conditions: Knowledge, Attitudes, Practice
Interventions: BEHAVIORAL: Obstetrics and Gynecology residents and experts'
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sofosbuvir, Ledipasvir, Ribavirin for Hepatitis C Cirrhotics, Genotype 1
Status: COMPLETED
Conditions: Hepatitis C|Cirrhosis
Interventions: DRUG: Sofosbuvir|DRUG: Ledipasvir|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Circadian Rhythmicity During Coma Awakening
Status: NOT_YET_RECRUITING
Conditions: Acute Brain Injury Coma
Interventions: BEHAVIORAL: Repeated behavioural assessment|BEHAVIORAL: Act-Pass paradigm|BEHAVIORAL: Biological measures of circadian and monoamines biomarkers|BEHAVIORAL: Transcriptomic and genomic analysis|BEHAVIORAL: Polysomnography with concomitant environment recording|BEHAVIORAL: Actimetry|BEHAVIORAL: Morphological MRI|BEHAVIORAL: Assessment of correlation between patients' behaviour and neurophysiological markers of consciousness.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Modifying (Phase I) and Evaluating (Phase II) Virtual Reality Job Interview Training for Youth in Transition
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Virtual Reality Job Interview Training|BEHAVIORAL: Services as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of the mRNA COVID-19 Vaccines in Healthy Children Between 6 Months to Less Than 6 Years of Age
Status: RECRUITING
Conditions: SARS-CoV-2
Interventions: BIOLOGICAL: mRNA-1273.214|BIOLOGICAL: mRNA-1273.815
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Primary Cholangioscopy Versus ERCP in the Diagnosis of Biliary Strictures
Status: UNKNOWN
Conditions: Biliary Stricture
Interventions: PROCEDURE: Peroral Cholangioscopy and Endoscopic retrograde cholangiopancreatography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Objective is to Respond to Patients' Needs in the Field of Larynx Replacement
Status: COMPLETED
Conditions: Swallowing Disorders|Dysphagia|Laryngeal Neoplasms
Interventions: DEVICE: Implantation of intralaryngeal prosthesis with a new double valve system, allowing tracheotomy closing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post EVAR Endoleak Detection : Model-based Iterative Reconstruction (MBIR) vs Adaptive Statistical Iterative Reconstruction (ASIR) CTA; a Prospective Study
Status: COMPLETED
Conditions: Post EVAR Endoleak Detection
Interventions: OTHER: abdominal MDCT examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sulfadoxine-pyrimethamine Plus Dihydroartemisinin-piperaquine for Intermittent Preventive Treatment in Pregnancy
Status: ACTIVE_NOT_RECRUITING
Conditions: Malaria|Malaria in Pregnancy|Pregnancy Related
Interventions: DRUG: Dihydroartemisinin-Piperaquine (DP)|DRUG: Sulfadoxine pyrimethamine (SP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Valuation of the Antioxidant and Neuroprotective Effects of CoQ10-MINIACTIVES® (COQUN® OS) in Patients Affected by Primary Open Angle Glaucoma
Status: UNKNOWN
Conditions: Glaucoma, Open-Angle
Interventions: DIETARY_SUPPLEMENT: CoQ10- MINIACTIVES|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Virus DNX2401 and Temozolomide in Recurrent Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma Multiforme|Recurrent Tumor
Interventions: PROCEDURE: DNX2401 and Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Changes of Body Fat Distribution in Obese Patients With PCOS After LSG
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: PROCEDURE: laparoscopic sleeve gastrectomy (LSG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vonoprazan-based Therapy Versus Standard Regimen for Helicobacter Pylori Infection Management
Status: RECRUITING
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: standard Clarithromycin triple therapy|DRUG: Vonoprazan triple therapy|DRUG: Vonoprazan dual therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paternal vs Maternal Holding-Cuddling for Procedural Pain in Healthy Term Neonates
Status: COMPLETED
Conditions: Procedural Pain
Interventions: BEHAVIORAL: Holding
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Suberoylanilide Hydroxamic Acid in Treating Patients With Advanced Solid Tumors That Have Not Responded to Previous Therapy
Status: COMPLETED
Conditions: Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Prostate Cancer|Small Intestine Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Laser Acupuncture for Meniere Disease
Status: RECRUITING
Conditions: Meniere Disease
Interventions: DEVICE: Multiwave Locked System (MLS) laser (Mphi laser, ASA Srl, Vicenza, Italy)|DRUG: Betahistine Mesylate tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing One or Two Doses of the Human Papillomavirus Vaccine for the Prevention of Human Papillomavirus Infection, ESCUDDO Study
Status: ENROLLING_BY_INVITATION
Conditions: Human Papillomavirus Infection|Human Papillomavirus-Related Cervical Carcinoma
Interventions: BIOLOGICAL: Diphtheria Toxoid/Tetanus Toxoid/Acellular Pertussis Vaccine Adsorbed|OTHER: Questionnaire Administration|BIOLOGICAL: Recombinant Human Papillomavirus Bivalent Vaccine|BIOLOGICAL: Recombinant Human Papillomavirus Nonavalent Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: S9031-S9126-S9333-S9500-B Biomarker Expression in Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: GENETIC: DNA analysis|GENETIC: RNA analysis|GENETIC: mutation analysis|GENETIC: polymerase chain reaction|GENETIC: polymorphism analysis|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Virtual Individual Cognitive Stimulation Therapy: a Proof of Concept Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Dementia|Dementia, Vascular|Dementia, Mixed|Dementia With Lewy Bodies|Dementia Frontal|Dementia, Mild|Dementia Moderate|Dementia Alzheimers|Dementia of Alzheimer Type|Dementia, Multi-Infarct|Dementia Frontotemporal
Interventions: OTHER: Virtual Individual Cognitive Simulation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial for Treatment Refractory Trigeminal Neuralgia
Status: TERMINATED
Conditions: Trigeminal Neuralgia
Interventions: DRUG: Rimegepant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate in Treating Patients With Recurrent Meningioma
Status: COMPLETED
Conditions: Adult Grade I Meningioma|Adult Grade II Meningioma|Adult Grade III Meningioma|Adult Meningeal Hemangiopericytoma|Adult Meningioma|Recurrent Adult Brain Tumor
Interventions: DRUG: imatinib mesylate|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Somatropin on Left Ventricular Mass in Growth Hormone Deficient Adult Patients
Status: COMPLETED
Conditions: Growth Hormone Disorder|Adult Growth Hormone Deficiency
Interventions: DRUG: somatropin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Liposomal Irinotecan With Cisplatin and Concurrent Radiotherapy in Locally Advanced Esophageal Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Liposomal Irinotecan Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide With or Without Rituximab in Treating Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Who Have Undergone Autologous or Syngeneic Stem Cell Transplant
Status: WITHDRAWN
Conditions: Leukemia|Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Vasopressin on Glucose Regulation
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: OTHER: Hypertonic Saline (3% NaCl)|OTHER: Isotonic Saline (0.9% NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Conservative Management for Adolescent Idiopathic Scoliosis
Status: RECRUITING
Conditions: Scoliosis; Adolescence
Interventions: OTHER: Scoliosis-Specific Exercise Program|OTHER: Soft orthoses with external strapping.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Superficial Basal Cell Carcinoma
Status: COMPLETED
Conditions: Basal Cell Carcinoma
Interventions: DRUG: PEP005
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Caffeine Optimization Versus Standard Caffeine Dosage (2B-2)
Status: RECRUITING
Conditions: Sleep Deprivation|Caffeine
Interventions: DIETARY_SUPPLEMENT: Caffeine Gum|OTHER: Placebo Gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Vaccine Therapy in Treating Patients With Advanced or Metastatic Cancer
Status: COMPLETED
Conditions: Breast Cancer|Colorectal Cancer|Gallbladder Cancer|Gastric Cancer|Head and Neck Cancer|Liver Cancer|Ovarian Cancer|Pancreatic Cancer|Testicular Germ Cell Tumor
Interventions: BIOLOGICAL: TRICOM-CEA(6D)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Surgical Practices in Patients With Haemophilia A or B Treated With an Extended Half-life Recombinant Factor VIII-Fc or IX-Fc (ELOCTA®, ALPROLIX®)
Status: RECRUITING
Conditions: Hemophilia A|Hemophilia B
Interventions: DRUG: Describe the respective haemostatic efficacy of Elocta® for haemopilia A during surgical procedures|DRUG: Describe the respective haemostatic efficacy of Alprolix® for haemopilia B during surgical procedures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Pediatric
Status: TERMINATED
Conditions: Caries,Dental|Apical Periodontitis
Interventions: DRUG: Kovanaze Nasal Spray|DRUG: Articaine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of PADMA 28 on Endothelial Function, Autonomic Nervous System and Biomarkers in Patients With Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: PADMA 28|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fatty Liver Response of Cardio-metabolic Risk Factors to Laser Acupuncture Versus Cupping
Status: UNKNOWN
Conditions: Fatty Liver
Interventions: DEVICE: laser stimulation for acupoints|OTHER: cupping with scarification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repeatability of OCT and IV-US in Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: PROCEDURE: Patients with Pulmonary Arterial Hypertension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Low-level Laser Therapy in Patients With Chronic Fibromyalgia
Status: TERMINATED
Conditions: Chronic Pain
Interventions: DEVICE: Sham Phoenix Laser Treatment|DEVICE: Active Phoenix Laser Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pemetrexed, Carboplatin and Bevacizumab in Participants With Nonsquamous Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Pemetrexed|DRUG: Pemetrexed|DRUG: Paclitaxel|DRUG: Carboplatin|BIOLOGICAL: Bevacizumab|BIOLOGICAL: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Acu-Transcutaneous Electrical Nerve Stimulation (Acu-TENS) on Post-exercise Blood Lactate and Excessive Post-exercise Oxygen Consumption (EPOC)
Status: UNKNOWN
Conditions: Healthy Subjects
Interventions: DEVICE: Transcutaneous electrical nerve stimulation (TENS)|DEVICE: Transcutaneous electrical nerve stimulation (TENS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot-testing a Perinatal Palliative Care Intervention Program
Status: NOT_YET_RECRUITING
Conditions: Perinatal Palliative Care|Life-limiting Fetal Diagnosis|Life-limiting Neonatal Diagnosis
Interventions: BEHAVIORAL: Perinatal palliative care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Administration of CMV-Specific Cytotoxic T Cells in Patients With Glioblastoma Multiforme
Status: TERMINATED
Conditions: Glioblastoma Multiforme|GBM|Brain Cancer
Interventions: BIOLOGICAL: Autologous CMV-specific CTL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficiency of the French Translation Social Cognition and Interactive Training (SCIT)Program
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Social Cognition and Interaction Training (SCIT)|BEHAVIORAL: therapeutic education program (ETP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a New Model of Metallic Bar and Stabilizer for Use in MIRPE
Status: COMPLETED
Conditions: Funnel Chest
Interventions: DEVICE: Implantation of new model of bar with oblique stabilizers|DEVICE: Implantation of regular bar with perpendicular stabilizers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calcium, Protein and Gut Hormones
Status: COMPLETED
Conditions: Obesity|Diabetes
Interventions: DIETARY_SUPPLEMENT: Calcium Citrate|DIETARY_SUPPLEMENT: Milk Mineral Supplement|DIETARY_SUPPLEMENT: Whey Protein Hydrolysate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Evaluation of the OncAlert RAPID in Subjects Presenting for Evaluation and/or Initial Biopsy; Impact on Decision-Making
Status: COMPLETED
Conditions: Palatal Neoplasms|Lip Neoplasm|Gingival Neoplasms|Leukoplakia, Oral|Tongue Neoplasms|Oropharyngeal Neoplasms|Oral Ulcer
Interventions: DEVICE: OncAlert
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomized Study of Docetaxel +/- Vandetanib in Metastatic TCC
Status: COMPLETED
Conditions: Transitional Cell Carcinoma|Bladder Cancer
Interventions: DRUG: Docetaxel|DRUG: vandetanib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: HAIC Combine Tislelizumab and Lenvatinib in the Treatment of HCC With Type IV (Vp4) Portal Vein Tumor Thrombus (HAI-TL)
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma With PVTT
Interventions: DRUG: Tislelizumab|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Tedizolid Phosphate in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Tedizolid PO|DRUG: Tedizolid IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Roller Massage on Short-Term Passive Muscle Stiffness
Status: COMPLETED
Conditions: Muscle Tightness
Interventions: PROCEDURE: Sham Therapeutic Ultrasound|PROCEDURE: Medium-Intensity Roller Massage|PROCEDURE: High-Intensity Roller Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Characterization of the Gastrointestinal Microbiota in Term Newborn Infants After 4 Weeks Supplementation of Probiotics
Status: COMPLETED
Conditions: Gut Microbiota
Interventions: DIETARY_SUPPLEMENT: Probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Post-Operative Radiotherapy De-Escalation of Negative Nodal Regions in Head and Neck Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Head and Neck Carcinoma
Interventions: RADIATION: Elective nodal de-escalation arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate Efficacy and Safety of Ribociclib With Endocrine Therapy as Adjuvant Treatment in Patients With HR+/HER2- Early Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Early Breast Cancer
Interventions: DRUG: Ribociclib|OTHER: Endocrine Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Cohort Study for Asthma in China
Status: RECRUITING
Conditions: Asthma, Bronchial
Interventions: DIAGNOSTIC_TEST: Diagnostic Test: lung function test, chest CT, induced sputum, blood routine test, IgE test, FeNO test, six minutes walk test, questionnaires for asthma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Histamine H1/H2 Receptors and Training Adaptations
Status: COMPLETED
Conditions: Exercise Training|Physical Activity
Interventions: OTHER: Lactose|DRUG: Fexofenadine Hydrochloride|DRUG: Famotidine|OTHER: High-intensity interval training (HIIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Corticosteroid And Ozone Injection In Patıents With Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: OTHER: splint and exercise and advices|OTHER: Triamsinolon Asetonid ozone|OTHER: ozone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Capecitabine and Bevacizumab ± Vinorelbine in Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: capecitabine|DRUG: bevacizumab|DRUG: capecitabine|DRUG: bevacizumab|DRUG: vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Colchicine on Perioperative Anti-inflammatory Organ Injury in Cardiac Surgery
Status: RECRUITING
Conditions: Inflammatory Response|Cardiac Disease
Interventions: DRUG: Colchicine 0.5 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyaluronic Acid for Residual Periodontal Pockets Adjunctive Treatment
Status: COMPLETED
Conditions: Periodontitis
Interventions: DRUG: Hyaluronic Acid|DRUG: Lidocain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Using Point-of-Care-Ultrasound (POCUS) to Assess Gastric Contents Among Fasting Pre-operative Patients Taking GLP-1 Agonists.
Status: COMPLETED
Conditions: Delayed Gastric Emptying|Gastroparesis
Interventions: DIAGNOSTIC_TEST: gastric ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 3 Study to Evaluate the Efficacy and Safety of ORMD-0801 in Subjects With Type 2 Diabetes Mellitus
Status: TERMINATED
Conditions: T2DM (Type 2 Diabetes Mellitus)
Interventions: DRUG: ORMD-0801|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Expectation and Knowledge on Rizatriptan and Placebo Treatment of Acute Migraine Headache
Status: COMPLETED
Conditions: Episodic Migraine
Interventions: DRUG: Maxalt|DRUG: placebo pill|DRUG: placebo pills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Effects of Food and Esomeprazole on the Pharmacokinetics of Crizotinib in a Coated Microsphere Formulation.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Crizotinib|DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Antibiotic Prophylaxis in Gynecologic Laparoscopy
Status: COMPLETED
Conditions: Infection Secondary to Surgical Procedure
Interventions: PROCEDURE: gynecologic laparoscopy|DRUG: Cefazolin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 3 Study for the Efficacy and Safety of Radotinib in CP-CML Patients With Failure or Intolerance to Previous TKIs
Status: RECRUITING
Conditions: Chronic Myeloid Leukemia, Chronic Phase|CML, Chronic Phase|CML, Refractory|CML - Philadelphia Chromosome
Interventions: DRUG: Radotinib HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zinc for Infection Prevention in Sickle Cell Anemia (ZIPS)
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DIETARY_SUPPLEMENT: Zinc|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Breaststroke Swimming After Breast Cancer Treatment/Surgery as a Means of Treatment for Seroma, Lymphedema, and Chronic Arm and Chest Pain
Status: RECRUITING
Conditions: Lymphedema|Seroma|Pain, Postoperative|Pain, Chest
Interventions: BEHAVIORAL: Swimming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of TWP-101 in Patients With Advanced Melanoma and Urothelial Carcinoma
Status: UNKNOWN
Conditions: Advanced Melanoma|Advanced Urothelial Carcinoma
Interventions: DRUG: TWP-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Transplantation of UC-MSC in Patients With Late Stage of Chronic Spinal Cord Injury
Status: UNKNOWN
Conditions: Spinal Cord Injuries
Interventions: DRUG: Umbilical Cord Mesenchymal Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Oxygen Therapy (HBOT) in Chronic Traumatic Brain Injury (TBI)/Post Concussion Syndrome (PCS) and TBI/Post-Traumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: TBI (Traumatic Brain Injury)|Post Concussion Syndrome|Post Traumatic Stress Disorder|Chronic Post Traumatic Stress Disorder
Interventions: DRUG: Low pressure hyperbaric oxygen therapy|DRUG: Low pressure hyperbaric oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gene Therapy for X-linked Chronic Granulomatous Disease (CGD) in Children
Status: COMPLETED
Conditions: Chronic Granulomatous Disease
Interventions: GENETIC: retroviral SF71-gp91phox transduced CD34+ cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Pharmacodynamic Effect of a Single Dose of AZD2516 in Healthy Male Subjects
Status: COMPLETED
Conditions: Reflux
Interventions: DRUG: AZD2516, 5 mg|DRUG: AZD2516, 16 mg|DRUG: AZD2516, 40 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Semaglutide for the Reduction of Arrhythmia Burden in Overweight AF Patients
Status: WITHDRAWN
Conditions: Atrial Fibrillation|Overweight and Obesity
Interventions: DRUG: Semaglutide Injectable Product|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Performed Examination for Patients With Intra-articular Hip Pain
Status: COMPLETED
Conditions: Hip Pain Chronic|Hip Disease
Interventions: OTHER: Patient Self-Administered Diagnostic Exam|OTHER: Clinician-Performed Diagnostic Exam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Buccal Versus Intranasal Route of Administration of Midazolam Spray in Behavior Management of Pre-School Patients
Status: COMPLETED
Conditions: Dental Anxiety
Interventions: DRUG: Buccal midazolam|DRUG: Intranasal midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: TAK-935 Multiple Rising Dose Study in Healthy Participants
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: TAK-935|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants
Status: UNKNOWN
Conditions: Infant, Premature|Leukomalacia, Periventricular|Intraventricular Hemorrhage|Retinopathy of Prematurity
Interventions: DRUG: recombinant human erythropoietin (rhEpo)|DRUG: recombinant human erythropoietin (rhEpo)|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Venetoclax With Obinutuzumab and Magrolimab (VENOM) in Relapsed and Refractory Indolent B-cell Malignancies
Status: COMPLETED
Conditions: Follicular Lymphoma|Marginal Zone Lymphoma|Mantle Cell Lymphoma|Chronic Lymphocytic Lymphoma|B-Cell Lymphoma
Interventions: DRUG: Obinutuzumab|DRUG: Venetoclax|DRUG: Magrolimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tegoprazan Dual Therapy and Furazolidone-based Bismuth Quadruple Therapy for Helicobacter Pylori Eradication: A Prospective, Multicenter, Open-label, Randomized Controlled Clinical Study
Status: NOT_YET_RECRUITING
Conditions: Helicobacter Pylori Infection|Tegoprazan|Furazolidone
Interventions: BIOLOGICAL: Tegoprazan-amoxicillin dual therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy and Intratumoral Autologous Dendritic Cells in Soft Tissue Sarcomas (STS)
Status: COMPLETED
Conditions: Soft Tissue Sarcoma
Interventions: PROCEDURE: External Beam Radiation Therapy (RT)|BIOLOGICAL: Autologous Dendritic Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Cardiac Rehabilitation Exercise Using Target Heart Rate Trial
Status: RECRUITING
Conditions: Myocardial Infarction|Coronary Artery Bypass|Percutaneous Coronary Intervention|Heart Failure|Cardiac Valve Surgery
Interventions: BEHAVIORAL: RPE (usual care)|BEHAVIORAL: GXT+THHR (intervention)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploring the Role of the GABAergic Modulation in Pain Transmission in Human
Status: COMPLETED
Conditions: Neuropathic Pain
Interventions: DRUG: NDMC 20mg|DRUG: NDMC60mg|DRUG: Clonazepam 1.5mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Are SARS-CoV-2 Specific Antibodies a Correlate for Protection?
Status: COMPLETED
Conditions: SARS-CoV2|COVID-19
Interventions: DIAGNOSTIC_TEST: Assessing antibody responses, neutralizing capacity and memory B-cell function
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: BromhexIne And Spironolactone For CoronаVirUs Infection Requiring HospiTalization
Status: UNKNOWN
Conditions: COVID 19
Interventions: DRUG: Bromhexine and Spironolactone|DRUG: Base therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MONITORING OF ATTENTION ACCORDING TO FATIGUE IN THE HEALTHY SUBJECT
Status: RECRUITING
Conditions: FATIGUE|Sleep Deprivation
Interventions: DEVICE: NaoX Intra-Auricular Device (IAD) monitoring EEG data|BEHAVIORAL: Simple psychometric tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dissociating Components of Anhedonia: A Pilot fMRI Study
Status: COMPLETED
Conditions: Anhedonia
Interventions: OTHER: Functional Magnetic Resonance Imaging|OTHER: Effort-Expenditure for Rewards Task
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Compare the Bioavailability and Pharmacokinetics of Cyclosporine After Intravenous Administration of NEUROSTAT®, a CREMOPHOR® EL-free Lipid Emulsion, and SANDIMMUNE® Injection (a Suspension of Cyclosporine in CREMOPHOR® EL) in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Sandimmune® Injection|DRUG: NeuroSTAT®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Effect of Aged Garlic Extract (AGE) on Improving Coronary Atherosclerosis in People With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Coronary Arteriosclerosis|Endothelial Dysfunction|Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Aged Garlic Extract (AGE)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Safety and Tolerance of TQH3821 Tablets in Adult Healthy Subjects
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: TQH3821 tablets|DRUG: TQH3821 tablets (Placebo)|DRUG: Methotrexate tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Open-label, Multiple Dose Escalation Trial to Determine Safety and Tolerability of Once Daily OPB-111077 in Subjects With Advanced Cancer
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: OPB-111077
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Pembrolizumab (MK-3475) in Combination With Daratumumab in Participants With Relapsed Refractory Multiple Myeloma (MK-3475-668/KEYNOTE-668)
Status: WITHDRAWN
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: Pembrolizumab|BIOLOGICAL: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-emptive US Guided Superior Hypogastric Plexus Block in Pelvic Cancer Surgeries : a Randomized Double-Blinded Study
Status: UNKNOWN
Conditions: Analgesia
Interventions: PROCEDURE: Superior Hypogastric Plexus Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Immunogenicity of a Novel Vaccine for Prevention of Covid-19 in Adults Previously Immunized
Status: WITHDRAWN
Conditions: Covid19
Interventions: BIOLOGICAL: A vaccine composed of a recombinant S1 antigen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Double-blind, Randomised, Placebo-controlled, Rising Multiple Dose Study to Investigate the Safety, Tolerability, Steady State Pharmacokinetic Profile and CNS Effects of BIA 2-093
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Placebo|DRUG: BIA 2-093
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Carbamylation in Renal Disease-Modulation With Amino Acid Therapy
Status: COMPLETED
Conditions: End Stage Renal Failure on Dialysis
Interventions: DIETARY_SUPPLEMENT: Amino acid supplementation NephrAmine®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of AT-777 in Healthy Subjects and AT-777 in Combination With AT-527 in HCV-Infected Subjects
Status: WITHDRAWN
Conditions: Hepatitis C|Hepatitis C, Chronic|Chronic Hepatitis C|Hepatitis C Virus Infection|HCV Infection
Interventions: DRUG: AT-777|DRUG: Placebo|DRUG: AT-527
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of Omeprazole on the Pharmacokinetics of SPD422 (Anagrelide Hydrochloride) in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: SPD422|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes Following Vaginal Prolapse Repair and Mid Urethral Sling Trial
Status: COMPLETED
Conditions: Pelvic Organ Prolapse
Interventions: DEVICE: TVT|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CoQ10 and Exercise for Mitochondrial Dysfunction in Advance Kidney Disease
Status: RECRUITING
Conditions: End Stage Renal Disease
Interventions: DIETARY_SUPPLEMENT: CoQ10|DRUG: Placebo|BEHAVIORAL: HB-HIIT|BEHAVIORAL: Observational
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of the COVID-19 Pandemic on Fibromyalgia Patients
Status: COMPLETED
Conditions: Fibromyalgia|Chronic Low-back Pain
Interventions: OTHER: Perceived stress scale|OTHER: Fibromyalgia impact questionnaire|OTHER: The drugs used before and during the pandemic, the patient's job status, physical activity conditions, pain status
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tocilizumab for Patients With Cancer and COVID-19 Disease
Status: TERMINATED
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm|Pneumonia|Pneumonitis|Severe Acute Respiratory Distress Syndrome|Symptomatic COVID-19 Infection Laboratory-Confirmed
Interventions: BIOLOGICAL: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of the Safety and Effectiveness of Levofloxacin Compared With Imipenem/Cilastatin in Patients With Pneumonia Acquired During Hospitalization
Status: COMPLETED
Conditions: Nosocomial Pneumonia
Interventions: DRUG: levofloxacin; imipenem/cilastitin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Offsetting Hippocampal Degeneration in m-sTBI
Status: RECRUITING
Conditions: Traumatic Brain Injury|Degeneration|Memory; Loss, Mild, Following Organic Brain Damage
Interventions: BEHAVIORAL: Online Spatial Navigation Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Two Approaches to the Management of Type 2 Diabetes Mellitus in Australian Primary Care
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: INSULIN GLARGINE (HOE901)|DRUG: Oral Anti Diabetics (OAD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Coronavirus Disease of 2019 (COVID-19) Rehabilitation Clinics in Saudi Arabia
Status: NOT_YET_RECRUITING
Conditions: Fatigue|Cardiopulmonary Arrest|Physical Inactivity|Muscle Weakness|Stress, Emotional|Dyspnea
Interventions: OTHER: Physical Therapy Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Patients With DIPG
Status: TERMINATED
Conditions: Diffuse Intrinsic Pontine Glioma|Diffuse Midline Glioma
Interventions: COMBINATION_PRODUCT: SONALA-001 (ALA) and MR-Guided Focused Ultrasound device (MRgFUS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT