pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Safety, Efficacy and Pharmacokinetic Study of Siltuximab (CNTO 328) in Participants With Solid Tumors
Status: COMPLETED
Conditions: Ovarian Neoplasms|Pancreatic Neoplasms|Colorectal Neoplasms|Head and Neck Neoplasms|Lung Neoplasms
Interventions: DRUG: CNTO 328; Anti-interleukin-6 monoclonal antibody|DRUG: CNTO 328; Anti-interleukin-6 monoclonal antibody|DRUG: CNTO 328; Anti-interleukin-6 monoclonal antibody|DRUG: CNTO 328; Anti-interleukin-6 monoclonal antibody|DRUG: CNTO 328; Anti-interleukin-6 monoclonal antibody|DRUG: CNTO 328; Anti-interleukin-6 monoclonal antibody|DRUG: CNTO 328; Anti-interleukin-6 monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Early Diagnosis and Treatment of OSA on Hospital Readmission in Hospitalized Cardiac Patients
Status: SUSPENDED
Conditions: OSA|Heart Failure|Myocardial Infarction|Arrhythmia, Cardiac
Interventions: DEVICE: Continuous Positive Airway Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II INCB024360 Study for Patients With Myelodysplastic Syndromes (MDS)
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: INCB024360
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Endostar With Cisplatin and Capecitabine as 1st Line Treatment in the Advanced Gastric Cancer
Status: COMPLETED
Conditions: Advanced Gastric Cancer
Interventions: DRUG: endostar, cisplatin, capecitabine|DRUG: capecitabine|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DIETFITS Study (Diet Intervention Examining the Factors Interacting With Treatment Success
Status: COMPLETED
Conditions: Obesity|Insulin Resistance
Interventions: BEHAVIORAL: Low-Carbohydrate Diet|BEHAVIORAL: Low-Fat Diet|BEHAVIORAL: Mobile App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioural Text Messages to Improve Retention in Care in South Africa
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: BEHAVIORAL: Standard of Care (SOC) text message reminder to attend clinic appointment|BEHAVIORAL: Loss aversion framed text message reminder to attend clinic appointment|BEHAVIORAL: Social norms framed text message reminder to attend clinic appointment|BEHAVIORAL: Altruism framed text message reminder to attend clinic appointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Safety, Tolerability and Preliminary Efficacy of JK1201I in Patients With SCLC
Status: UNKNOWN
Conditions: Small Cell Lung Cancer (SCLC)
Interventions: DRUG: JK-1201I
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Identifying the Optimal Neural Target for Misophonia Interventions
Status: COMPLETED
Conditions: Misophonia|Emotion Dysregulation
Interventions: BEHAVIORAL: Cognitive Restructuring|DEVICE: neurostimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)
Status: RECRUITING
Conditions: Generalized Anxiety Disorder
Interventions: DEVICE: Active LIFUP Treatment|DEVICE: Sham LIFUP Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TMC435HPC3001 - An Efficacy, Safety and Tolerability Study for TMC435 vs Telaprevir in Combination With PegINFα-2a and Ribavirin in Chronic Hepatitis C Patients Who Were Null or Partial Responders to Prior PegINFα-2a and Ribavirin Therapy
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: TMC435|DRUG: TVR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 1
Status: RECRUITING
Conditions: Post-Traumatic Headache
Interventions: DRUG: Bupivacaine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Decentralized, Randomized Phase 2 Efficacy and Safety Study of Nirmatrelvir/Ritonavir in Adults With Long COVID.
Status: ACTIVE_NOT_RECRUITING
Conditions: Long COVID
Interventions: DRUG: Nirmatrelvir|DRUG: Ritonavir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Methylsulfonylmethane (MSM) on Cardiometabolic Health
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: methylsulfonylmethane|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics (PK), Safety, Efficacy and Maximal Use PK of ARQ-151 in Adolescents/Children With Mild/Moderate Eczema
Status: COMPLETED
Conditions: Atopic Dermatitis (Eczema)
Interventions: DRUG: ARQ-151 cream 0.15%|DRUG: ARQ-151 cream 0.05%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Hepatitis C Virus (HCV)/Human Immunodeficient Virus (HIV) Risk Behaviors Among Injection Drug Users in China
Status: COMPLETED
Conditions: Hepatitis C
Interventions: BEHAVIORAL: intervention group|BEHAVIORAL: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: SElf-SAMpling in Cervical Cancer Screening; SESAM Study
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: DEVICE: HPV testing of Evalyn®Brush, FloqSwab and Colli-Pee specimens
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Vitamin D Supplementation to Prevent the Risk of Acquiring COVID-19 in Healthcare Workers
Status: COMPLETED
Conditions: Covid19|Vitamin D
Interventions: DRUG: Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluating the Clinical Efficacy and Safety of Hibero SR (Mirabegron) 50 mg and Ditropan (Oxybutynin Chloride) 10 mg in Children Between 5 and 18 Years With Overactive Bladder (OAB)
Status: NOT_YET_RECRUITING
Conditions: Overactive Bladder
Interventions: DRUG: Mirabegron 50 MG|DRUG: Oxybutynin Chloride 5 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Cellular Pharmacology of Tenofovir and Emtricitabine According to HIV Infection Status
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Emtricitabine (FTC)|DRUG: Tenofovir disoproxil fumarate (TDF)|DRUG: Efavirenz (EFV)|DRUG: Truvada
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization of Chitin-glucan Fiber Fermentation in Human After a Single Administration
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Chitin-glucan|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Safety and Preliminary Efficacy of Lipoxin Analog BLXA4-ME Oral Rinse for the Treatment of Gingivitis
Status: COMPLETED
Conditions: Gingival Inflammation
Interventions: DRUG: BLXA4|DRUG: Placebo oral rinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Deep Brain Stimulation in Patients With Incomplete Spinal Cord Injury for Improvement of Gait
Status: RECRUITING
Conditions: Spinal Cord Injury
Interventions: PROCEDURE: Deep brain stimulation in mesencephalic locomotor region|DEVICE: Implantation of a Deep brain stimulation system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modulation of Cognitive Control by Transcranial Direct Current Stimulation
Status: COMPLETED
Conditions: Major Depression
Interventions: DEVICE: Transcranial direct current stimulation (tDCS); DC-STIMULATOR (NeuroConn GmbH, Ilmenau, Germany)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Xanamem® in Adults With Major Depressive Disorder and Impaired Cognition (XanaCIDD)
Status: COMPLETED
Conditions: Major Depressive Disorder|MDD|Cognitive Impairment
Interventions: DRUG: Xanamem™|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Brontictuzumab With Chemotherapy for Subjects With Previously Treated Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: brontictuzumab|DRUG: trifluridine/tipiracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vasopressor Infusion in Cesarean Delivery
Status: UNKNOWN
Conditions: Cesarean Section Complications|Spinal Anesthesia
Interventions: DRUG: Phenylephrine|DRUG: Norepinephrine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Therapeutic Effects of Intercessory Prayer (STEP)
Status: COMPLETED
Conditions: Coronary Artery Bypass Grafting Surgery
Interventions: BEHAVIORAL: Intercessory Prayer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Cipterbin®, Used Alone or With Vinorelbine in Patients With HER2/Neu-overexpressed Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: humanized anti-HER2 antibody|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenetic Treatments for Alcoholism
Status: WITHDRAWN
Conditions: Alcoholism
Interventions: DRUG: Ondansetron + Brief Behavioral Enhancement Treatment|DRUG: Placebo + Brief Behavioral Enhancement Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Clinical Study for Evaluation of Efficacy and Safety of EGF on Oral Mucositis in Radiation Therapy Patients
Status: UNKNOWN
Conditions: Stomatitis
Interventions: DRUG: rhEGF|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glucocorticoid Therapy for COVID-19 Critically Ill Patients With Severe Acute Respiratory Failure
Status: COMPLETED
Conditions: COVID-19 Infections
Interventions: DRUG: methylprednisolone therapy|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects on NF-κB Activity: High Dose Simvastatin Versus Combination Therapy With Ezetimibe
Status: COMPLETED
Conditions: Type 2 Diabetes|Inflammation
Interventions: DRUG: Simvastatin 80 mg|DRUG: Sim10/Eze10|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Photobiomodulation Protocols in Radiation-induced Oral Side Effects in H&N Cancer Patients
Status: RECRUITING
Conditions: Mucositis|Xerostomia|Hyposalivation
Interventions: DEVICE: Photobiomodulation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation
Status: COMPLETED
Conditions: Cancer
Interventions: BIOLOGICAL: palivizumab|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: LACunar Intervention (LACI-2) Trial-2
Status: COMPLETED
Conditions: Cerebral Small Vessel Diseases|Stroke, Lacunar
Interventions: DRUG: Isosorbide Mononitrate XL (ISMN)|DRUG: Cilostazol|DRUG: ISMN XL and Cilostazol|OTHER: Neither ISMN nor cilostazol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Derivatives of Omega-3 HUFA as Biomarkers of Traumatic Brain Injury
Status: WITHDRAWN
Conditions: TBI
Interventions: DRUG: Omega 3 fatty acid|DIETARY_SUPPLEMENT: Safflower seed oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: SYL040012. Tolerance and Effect on Intraocular Pressure in Subjects With Intraocular Pressure (IOP) >= 21 mm Hg
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: SYL040012
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Neuroprotective Effects of Methylphenidate and Atomoxetine in Children With ADHD: A Lipidomic Study
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Methylphenidate|DRUG: Atomoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Asses the Function and Patency of Polyester-Coated Composite Bypasses From Autologous Varicose Veins
Status: UNKNOWN
Conditions: Peripheral Arterial Disease|Peripheral Bypass Surgery|Bypass From Autologous Varicose Vein|External Graft Support
Interventions: DEVICE: Implantation of the ProVena vein graft during bypass surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetic, and Pharmacodynamic Study of NKTT120 in Adult Patients With Stable Sickle Cell Disease (SCD)
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: NKTT120
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention With Statin and Colchicine
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DRUG: Rosuvastatin|DRUG: Colchicine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Lung Clearance After Hypertonic Saline Delivery Using the tPAD Device
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: inhaled hypertonic saline (7%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S8814A Biomarkers in Predicting Outcome in Postmenopausal Women With Hormone Receptor-Positive, Node-Positive Breast Cancer Treated With Tamoxifen With or Without Cyclophosphamide, Doxorubicin, and Fluorouracil
Status: COMPLETED
Conditions: Breast Cancer
Interventions: GENETIC: comparative genomic hybridization|GENETIC: microarray analysis|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: diagnostic laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparing a Fatherhood Focused Individual Intervention to Batterer Intervention to Reduce IPV and Child Maltreatment
Status: COMPLETED
Conditions: Intimate Partner Violence
Interventions: BEHAVIORAL: F4C|BEHAVIORAL: BIP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Diclofenac Versus Avastin as Primary Treatment of Diffuse Diabetic Macular Edema
Status: UNKNOWN
Conditions: Diffuse Diabetic Macular Edema
Interventions: DRUG: Bevacizumab|DRUG: Diclofenac
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Capecitabine Associated With Weekly Paclitaxel in Metastatic Breast Cancer.
Status: COMPLETED
Conditions: Breast Cancer|Neoplasm Metastasis
Interventions: DRUG: Paclitaxel|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lamotrigine in Treatment Resistant Depression in Adolescents
Status: TERMINATED
Conditions: Adolescent Depression
Interventions: DRUG: Lamotrigine (drug)|DRUG: Fluoxetine (drug)|DRUG: sertraline (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: CD19 Chimeric Receptor Expressing T Lymphocytes In B-Cell Non Hodgkin's Lymphoma, ALL & CLL
Status: ACTIVE_NOT_RECRUITING
Conditions: B Cell Lymphoma|Chronic Lymphocytic Leukemia|Acute Lymphocytic Leukemia
Interventions: GENETIC: CD19CAR-28-zeta T cells|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DAMES: Daughters And MothErS Against Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Standardized Materials Group|BEHAVIORAL: Independent Tailored Intervention|BEHAVIORAL: Partner-Assisted Tailored Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Anterior Quadratus Lumborum Block at the Lateral Supra-arcuate Ligament for Analgesia After Open Liver Surgery
Status: COMPLETED
Conditions: Liver Surgery
Interventions: PROCEDURE: Ultrasound-guided anterior quadratus lumborum block at the lateral supra-arcuate ligament|PROCEDURE: Thoracic epidural analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nebulized Furosemide in Premature Infants With Bronchopulmonary Dysplasia - A Cross Over Pilot Study of Its Efficacy and Safety
Status: WITHDRAWN
Conditions: Premature Birth|Premature Infant
Interventions: DRUG: Inhaled Furosemide|DRUG: Intravenous Furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I, Open-label, Ascending Dose Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of the Endothelin B Agonist, SPI-1620, in Patients With Recurrent or Progressive Carcinoma
Status: COMPLETED
Conditions: Carcinoma
Interventions: DRUG: SPI-1620
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KIDNET Versus Meditation/Relaxation - a Dissemination RCTT for Children in Sri Lanka Traumatized by the War and the Tsunami
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: BEHAVIORAL: KIDNET|BEHAVIORAL: Meditation-Relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tivantinib Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer
Status: TERMINATED
Conditions: Non Squamous, Non-small-cell Lung Cancer
Interventions: DRUG: Tivantinib|DRUG: Placebo|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MELD-ATG: Phase II, Dose Ranging, Efficacy Study of Anti-thymocyte Globulin (ATG) Within 6 Weeks of Diagnosis of Type 1 Diabetes (T1D)
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Anti-Human Thymocyte Immunoglobulin, Rabbit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AF Ablation With or Without ROX Coupler Study
Status: UNKNOWN
Conditions: Atrial Fibrillation|Hypertension
Interventions: PROCEDURE: Atrial fibrillation ablation|PROCEDURE: ROX Coupler insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: EAT-DUTA AndroCoV Trial
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Dutasteride 0.5 mg|DRUG: Azithromycin|DRUG: Nitazoxanide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Trial of Losartan Potassium in Participants With Eosinophilic Esophagitis (EoE)
Status: COMPLETED
Conditions: Eosinophilic Esophagitis
Interventions: DRUG: Losartan Potassium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Red Yeast Rice, Phytosterols and L-tyrosol on Lipid Profile and Endothelial Function
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: Combined nutraceutical|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Examine the Acute Impact of Veillonella Supplementation on Exercise and Lactate Responses
Status: COMPLETED
Conditions: Lactate Blood Increase|Exhaustion - Physiological
Interventions: DIETARY_SUPPLEMENT: Time to Exhaustion at velocity at VO2max
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Retrospective Evaluation of GGPSP's Safety and Clinical Performance for the Treatment of Lower Limbs Deformities.
Status: COMPLETED
Conditions: Genu Varum|Genu Valgum|Joint Diseases|Knee Deformity|Ankle Deformity|Length Inequality, Leg|Discrepancy Length; Congenital|Deformity of Limb
Interventions: DEVICE: Guided Growth Plate System Plus
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: DELTA Trial: Does Embolization With Larger Coils Lead to Better Treatment of Aneurysms Trial
Status: COMPLETED
Conditions: Cerebral Aneurysm
Interventions: DEVICE: Endovascular coiling with standard 10-caliber platinum coils or 15-caliber platinum coils
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Tethered Capsule Endomicroscopy as a Screening Tool for Barrett's Esophagus in the Primary Care Setting
Status: ENROLLING_BY_INVITATION
Conditions: Barrett Esophagus|Barrett's Esophagus Without Dysplasia|Barretts Esophagus With Dysplasia
Interventions: DEVICE: Tethered Capsule Endomicroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Neoadjuvant and Adjuvant Fenretinide Compared With Adjuvant Fenretinide Alone in Treating Patients Who Are Undergoing Surgical Resection For Recurrent Glioblastoma Multiforme
Status: TERMINATED
Conditions: Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Recurrent Adult Brain Tumor
Interventions: DRUG: fenretinide|PROCEDURE: therapeutic conventional surgery|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cannabidiol in Opioid Use Disorder and Chronic Pain
Status: RECRUITING
Conditions: Chronic Pain
Interventions: DRUG: 400mg Cannabidiol|DRUG: 800mg Cannabidiol|DRUG: 1200mg Cannabidiol|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fibroblast Growth Factor 23 and Sclerostin in Relation to Calcium in COVID-19 Patients
Status: COMPLETED
Conditions: COVID-19
Interventions: DIAGNOSTIC_TEST: Calcium|DIAGNOSTIC_TEST: Fibroblast growth factor 23|DIAGNOSTIC_TEST: Sclerostin|DIAGNOSTIC_TEST: parathyroid hormone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prevention of Growth Retardation by Early Treatment With Growth Hormone (GH) in Children With CJA Treated by Corticosteroid Therapy
Status: TERMINATED
Conditions: Endocrine System Diseases
Interventions: DRUG: Somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Decision Aid for Hydroxyurea in Sickle Cell Disease
Status: TERMINATED
Conditions: Sickle Cell Disease
Interventions: OTHER: Training for use of web based Decision Aid|OTHER: No training for use of web based Decision Aid|OTHER: Pretest surveys and posttest surveys|OTHER: Only posttest surveys
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of MK-1200 in Participants With Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumors
Interventions: BIOLOGICAL: MK-1200|DRUG: Antiemetic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cannabidiol and CES1 Interactions in Healthy Subjects
Status: COMPLETED
Conditions: Drug Interaction
Interventions: DRUG: dl-Methylphenidate plus Cannabidiol|DRUG: dl-Methylphenidate plus Cannabidiol Placebo solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Trial of Ixazomib for Kaposi Sarcoma
Status: RECRUITING
Conditions: Kaposi Sarcoma|Skin
Interventions: DRUG: Ixazomib Citrate|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity of Herpes Zoster Subunit Vaccine in Inflammatory Bowel Disease Patients Treated With Vedolizumab
Status: ACTIVE_NOT_RECRUITING
Conditions: Inflammatory Bowel Diseases|Crohn Disease|Ulcerative Colitis|Herpes Zoster
Interventions: BIOLOGICAL: Shingrix
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of MG-K10 Humanized Monoclonal Antibody Injection in Patients With Atopic Dermatitis
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: MG-K10/Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label, Single- and Multi-Dose Pharmacokinetic (PK) Study of Oral Diltiazem and Topical Diltiazem Hydrochloride
Status: UNKNOWN
Conditions: Adult Subjects With Anal Fissures.
Interventions: DRUG: Diltiazem Hydrochloride Cream and Oral Diltiazem
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk of Gastric Insufflation Related to Facemask Ventilation Technique During Anaesthetic Induction, With or Without PEEP
Status: COMPLETED
Conditions: Air Insufflation|Regurgitation
Interventions: PROCEDURE: Mask ventilation with PEEP via a face mask device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide Therapy for Patients With Relapsed and/or Refractory, Peripheral T-Cell Lymphomas
Status: TERMINATED
Conditions: Peripheral T-cell Lymphomas|Adult T-cell Leukemia|Adult T-cell Lymphoma|Peripheral T-cell Lymphoma Unspecified|Angioimmunoblastic T-cell Lymphoma|Anaplastic Large Cell Lymphoma|T/Null Cell Systemic Type|Cutaneous t-Cell Lymphoma With Nodal/Visceral Disease
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Locally-Applied Simvastatin on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance Patients
Status: COMPLETED
Conditions: Periodontal Diseases
Interventions: OTHER: Methylcellulose|DRUG: Simvastatin-Methylcellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Prolonged Exposure for the Treatment of Posttraumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Prolonged Exposure|BEHAVIORAL: Applied Relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: REPRISE II: REpositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of Lotus™ Valve System
Status: COMPLETED
Conditions: Transcatheter Aortic Valve Replacement
Interventions: DEVICE: Lotus Valve System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Europe Based on Medical Records That Looks at the Safety of Dabigatran in Children Below 2 Years of Age Who Have Had a Blood Clot and Are at Risk of Developing Another Blood Clot
Status: WITHDRAWN
Conditions: Venous Thromboembolism
Interventions: DRUG: Dabigatran Etexilate (DE)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fluzoparib in Combination With Apatinib Mesylate for Maintenance Therapy in Stage III-IV Ovarian Cancer
Status: NOT_YET_RECRUITING
Conditions: Epithelial Ovarian Cancer|Efficacy|Safety|Bone Mineral Density|Tolerability
Interventions: DRUG: Fluzoparib|DRUG: Apatinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Bupivacaine (Exparel ® ) Plus 0.5% Bupivacaine HCL Versus 0.5% Bupivacaine HCL for Interscalene Nerve Block (ISB) for Patients Undergoing Total Shoulder Arthroplasty(TSA)
Status: COMPLETED
Conditions: Shoulder Pain
Interventions: DRUG: Liposomal Bupivacaine|DRUG: 0.5% Bupivacaine HCL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Removal of the Evolution® Esophageal Stent - Fully Covered
Status: COMPLETED
Conditions: Esophageal Fistula|Esophageal Neoplasms|Esophageal Perforation|Esophageal Stenosis|Stents
Interventions: DEVICE: Evolution® Esophageal Stent - Fully Covered
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epidural Analgesia During Labour
Status: COMPLETED
Conditions: Anesthesia, Obstetrical|Analgesia, Epidural
Interventions: DRUG: PIEB: Patient Intermittent Epidural Boluses|DRUG: PCEA: Patient Controlled Epidural Analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Full Mouth Erythritol Powder Air Polishing on Systemic Inflammatory Response
Status: ACTIVE_NOT_RECRUITING
Conditions: Periodontal Diseases
Interventions: PROCEDURE: test|PROCEDURE: conventional
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Phase Ⅳ Clinical Trial to Evaluate of Renamezin in Patients With Chronic Renal Failure.
Status: COMPLETED
Conditions: Chronic Renal Failure
Interventions: DRUG: Renamezin capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diabeloop For Teens
Status: RECRUITING
Conditions: Closed Loop|Diabetes Mellitus, Type 1|Adolescents (12 to 17 Years Old)
Interventions: DEVICE: Dexcom G6 Continuous Glucose Monitoring|DEVICE: MEDISAFE WITH External Insulin Pump|DEVICE: Diabeloop Software (Model predictive control)|OTHER: Declaration of meals|OTHER: No declaration of meals|OTHER: Remote monitoring (Telemedicine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of the Letrozole-induced Endometrial Preparation Protocol in Frozen-thawed Embryo Transfer (FET)
Status: RECRUITING
Conditions: Letrozole|Infertility, Female
Interventions: DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of Pregabalin (Lyrica) Drug Levels In Urine, Plasma And Breast Milk Of Healthy Lactating Women
Status: COMPLETED
Conditions: Healthy Lactating Women
Interventions: DRUG: pregabalin (Lyrica)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Effects of Underlying Renal or Hepatic Dysfunction on the Pharmacokinetics of Nevirapine
Status: COMPLETED
Conditions: Renal Insufficiency|Hepatic Insufficiency
Interventions: DRUG: Nevirapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Comedy Film on Preoperative Anxiety and Postoperative Pain Level.
Status: COMPLETED
Conditions: General Surgery|Anxiety|Pain
Interventions: BEHAVIORAL: comedy movie group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Understanding the Immune System's Role in Tree Nut and Peanut Allergies: Key Biomarkers for Diagnosis and Treatment Monitoring and Treatment Targets
Status: RECRUITING
Conditions: Food Allergy|Food Allergy in Children|Food Allergy Peanut|Tree Nut Allergies|Allergy;Food|Oral Immunotherapy for Food Allergy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Acular LS With Lotemax to Prevent Inflammation After Cataract Surgery and Intraocular Lens Implantation
Status: COMPLETED
Conditions: Cataract Extraction
Interventions: DRUG: Acular LS|DRUG: Lotemax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Biomarker Guided Therapies in Stage A/B Heart Failure
Status: COMPLETED
Conditions: Hypertension|Diabetes|Cardiovascular Disease
Interventions: DRUG: Carvedilol|DRUG: Spironolactone|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase I Study to Assess the Effect of Food on AZD1775 Pharmacokinetics in Patients With Advanced Solid Tumours
Status: COMPLETED
Conditions: Solid Tumours
Interventions: DRUG: Treatment A - AZD1775 administered under fasted conditions|DRUG: Treatment B - AZD1775 administered under fed conditions.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Prophylaxis With Fosfomycin Versus Ciprofloxacin Prior Prostate Biopsy
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: DRUG: Fosfomycin 3 g|DRUG: Ciprofloxacin 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immune Response to Pneumococcal Vaccination in Aging HIV Positive Adults
Status: COMPLETED
Conditions: HIV Lipodystrophy|Aging
Interventions: BIOLOGICAL: Pneumococcal polysaccharide vaccine 23 valent|BIOLOGICAL: 13 valent conjugated pneumococcal vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cetuximab and Capecitabine in Treating Patients With Metastatic Colorectal Cancer That Failed Irinotecan Treatment
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: capecitabine|GENETIC: gene expression analysis|GENETIC: microarray analysis|GENETIC: polymorphism analysis|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: immunohistochemistry staining method
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing an Adjustable Ankle Orthosis During Walking in Cerebral Palsy
Status: ACTIVE_NOT_RECRUITING
Conditions: Cerebral Palsy
Interventions: DEVICE: Differential and adjustable stiffness AFO (DAS-AFO)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Pharmacokinetics and Safety Study of Naloxegol in Paediatric OIC Patients
Status: COMPLETED
Conditions: Constipation, Signs and Symptoms, Digestive
Interventions: DRUG: Naloxegol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Local Anesthetic Techniques for Clavicular Surgeries
Status: ACTIVE_NOT_RECRUITING
Conditions: Anesthesia, Local
Interventions: PROCEDURE: Superior trunk block|PROCEDURE: Clavipectoral fascial plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Preventive Effect of 2-years Use of Hydroxyapatite Containing Toothpastes in Children.
Status: COMPLETED
Conditions: Caries
Interventions: OTHER: Toothpaste use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Effects of Dry Needling and Cross Friction Massage on Patients With Plantar Fascitis, RCT
Status: ACTIVE_NOT_RECRUITING
Conditions: Plantar Fascitis
Interventions: DIAGNOSTIC_TEST: Dry Needling|OTHER: Cross Friction Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Twelve vs 24 Months of Dual Antiplatelet Therapy in Patients With Coronary Revascularization for In-stent Restenosis
Status: UNKNOWN
Conditions: Percutaneous Coronary Intervention
Interventions: DRUG: 12 months of P2Y12 receptor antagonist|DRUG: 24 months of P2Y12 receptor antagonist|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cranial Radiotherapy Plus Chemoimmunotherapy in Untreated Driver-mutation Negative NSCLC With Stable Brain Metastasis
Status: RECRUITING
Conditions: NSCLC Stage IV|Brain Metastases
Interventions: DRUG: PD-L1/PD-1 inhibitor and chemotherapy|RADIATION: SRT or WBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Patient-controlled Analgesia Regimenfor Postoperative Pain in Patients Undergoing Total Knee Arthroplasty
Status: COMPLETED
Conditions: Postoperative Pain, Acute
Interventions: DRUG: Fentanyl|DRUG: ketorolac tromethamine with nefopam hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Radiation Cystitis Treated With Pentosan Polysulfate Sodium Trial
Status: RECRUITING
Conditions: Radiation Cystitis
Interventions: DRUG: Pentosan Polysulfate Sodium 100 MG Oral Capsule|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy With or Without Vinorelbine and Cisplatin in Treating Patients With Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: vinorelbine tartrate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Metallic Staples Versus Absorbable Staples After a Cesarean Section (C-Section)
Status: COMPLETED
Conditions: Cesarean Section
Interventions: DEVICE: Insorb absorbable staples|DEVICE: Insorb
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Interpretation of Health News Items Reporting Results of Phase I/II (Non-randomized) Trials With or Without Spin by English-speaking Population*
Status: WITHDRAWN
Conditions: The Study Focus on no Specific Condition
Interventions: OTHER: News items with spin|OTHER: News items without spin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study to Assess the Safety and Efficacy of MK8245 in Patients With Type 2 Diabetes Mellitus and Inadequate Glycemic Control (MK8245-005 AM2)
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: MK8245 5 mg (twice a day) b.i.d.|DRUG: MK8245 50 mg b.i.d.|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Local Therapies for Oligometastatic Non-Small Cell Lung Cancer Harboring Sensitizing EGFR Mutations
Status: COMPLETED
Conditions: Oligometastatic Lung Adenocarcinoma
Interventions: DRUG: Erlotinib|OTHER: Local Therapies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Supplementation With Amino Essential Acids on Circulating Albumin Levels in Stroke in Rehabilitation Phase
Status: COMPLETED
Conditions: Stroke Rehabilitation
Interventions: DIETARY_SUPPLEMENT: Amino Essential Acid|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Deep Brain Stimulation in Tourette Syndrome
Status: RECRUITING
Conditions: Tourette Syndrome|Deep Brain Stimulation
Interventions: DEVICE: Deep Brain Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Diosmectite (Smecta®) in the Symptomatic Treatment of Acute Diarrhoea in Adults
Status: COMPLETED
Conditions: Acute Diarrhoea
Interventions: DRUG: Smecta|DRUG: Smecta placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Assessing the Inhibitor of Programmed Cell Death Ligand 1 (PD-L1) Immune Checkpoint Atezolizumab
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Cervical Cancer
Interventions: DRUG: Atezolizumab|RADIATION: Radiotherapy|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I and II Study of Auranofin in Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia (CLL)|Small Lymphocytic Lymphoma|Leukemia, Prolymphocytic
Interventions: DRUG: auranofin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Xentuzumab (BI 836845) Plus Afatinib in Patients With Epidermal Growth Factor Receptor (EGFR) Mutant Non-small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: BI 836845|DRUG: afatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Testosterone Treatment on Clitoral Arteries' Hemodynamic Parameters.
Status: COMPLETED
Conditions: Hypoactive Sexual Desire Disorder|Vulvovaginal Disease|Menopause Related Conditions|Dyspareunia (Female Excluding Psychogenic)|Hypoestrogenism|Arousal Disorders, Sexual
Interventions: DRUG: Testosterone gel|DRUG: Estradiol ovules|DRUG: Moisturizer|DRUG: Testosterone gel + Estradiol ovules
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p