pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Vitamin D + Telaprevir + Peginterferon + Ribavirin for of Hepatitis C Genotype 1
Status: WITHDRAWN
Conditions: Hepatitis C
Interventions: DRUG: Telaprevir|DRUG: Peginterferon alfa-2a|DRUG: Ribavirin|DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crossover Drug-Drug Interaction Study to Determine Effects of Cytochrome P450 3A on Exposure to Mifepristone and Its Metabolites
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Mifepristone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Hybrid Fractional Laser Treatment for Symptoms of Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence|Stress Urinary Incontinence|Urge Incontinence
Interventions: DEVICE: Hybrid Fractional Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pro-resolving Effect of MAG-DHA in Cystic Fibrosis (PREMDIC)
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DIETARY_SUPPLEMENT: MAG-DHA|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing the Laryngeal Tube Suction Disposable and the Supreme Laryngeal Mask Airway
Status: COMPLETED
Conditions: Adverse Anesthesia Outcome
Interventions: DEVICE: Supreme Laryngeal Mask Airway|DEVICE: Laryngeal Tube Suction Disposable
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Different Propofol Formulations
Status: COMPLETED
Conditions: General Anesthesia
Interventions: DRUG: Propofol Astrazeneca plain|DRUG: Propofol Astrazeneca plus lidocaine|DRUG: Propofol-lipuro B. Braun plain|DRUG: Propofol-lipuro B. Braun plus lidocaine|DRUG: Propofol Fresenius plain|DRUG: Propofol Fresenius plus lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Genetic Evaluation and Modification of Lifestyles to Improve Female Life Expectancy
Status: TERMINATED
Conditions: Menopause Syndrome|Inflammation|Inflammatory Response|Aging|Menopause|Telomere Shortening|Stress Oxidative
Interventions: BEHAVIORAL: Mediterranean diet|BEHAVIORAL: AHA walking program|BEHAVIORAL: Mindfulness-based stress reduction|BEHAVIORAL: Unstructured Mediterranean diet|BEHAVIORAL: Unstructured walking program|BEHAVIORAL: Unstructured stress reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: MRI to Assess the Effect of Terlipressin in Patients With Acute Hepatorenal Syndrome (HRS-AKI)
Status: COMPLETED
Conditions: Hepato-Renal Syndrome|Portal Hypertension|Acute Kidney Injury|Liver Diseases|Liver Cirrhoses|Cirrhosis Cardiac|Cirrhosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Determine AF Burden With PPG Trial - Detection and Quantification of Episodes of Atrial Fibrillation
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: PPG Smartwatch
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Nitazoxanide in the Treatment of Clostridium Difficile Colitis
Status: COMPLETED
Conditions: Clostridium Difficile
Interventions: DRUG: Nitazoxanide|DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Electrophysiologic and Morphologic Assessment of the Substrate to Guide Implantation of Defibrillators in Dilated Cardiomyopathy
Status: UNKNOWN
Conditions: Dilated Cardiomyopathy|Primary Prevention of Sudden Cardiac Death|Implantable Cardioverter Defibrillator
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Armodafinil on Cognition for Patients With Schizophrenia or Schizoaffective Disorder
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: armodafinil (Nuvigil)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study of One Booster Dose of Trivalent COVID-19 Vaccine (Vero Cell), Inactivated
Status: NOT_YET_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: Trivalent COVID-19 Vaccine (Vero Cell), Inactivated, Prototype Strain, Delta Strain and Omicron Strain|BIOLOGICAL: COVID-19 Vaccine (Vero Cell), Inactivated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Blocking Blue Light in Pregnancy, Effects on Melatonin Profile and Sleep
Status: ACTIVE_NOT_RECRUITING
Conditions: Sleep Disturbance
Interventions: DEVICE: Blue-blocking glasses|DEVICE: Light grey control glasses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intravenous Dexketoprofen and Tenoxicam on Propofol Associated Injection Pain
Status: COMPLETED
Conditions: Injection Pain
Interventions: DRUG: saline|DRUG: dexketoprofen|DRUG: tenoxicam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: High-Dose Y-90-Ibritumomab Tiuxetan Added to Reduced-Intensity Allogeneic Stem Cell Transplant Regimen for Relapsed or Refractory Aggressive B-Cell Lymphoma
Status: TERMINATED
Conditions: Post-Transplant Lymphoproliferative Disorder|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent B-Cell Non-Hodgkin Lymphoma|Recurrent Burkitt Lymphoma|Refractory B-Cell Non-Hodgkin Lymphoma|Refractory Burkitt Lymphoma|Refractory Diffuse Large B-Cell Lymphoma
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Cyclosporine|DRUG: Fludarabine Phosphate|RADIATION: Indium In-111 Ibritumomab Tiuxetan|DRUG: Mycophenolate Mofetil|OTHER: Pharmacological Study|BIOLOGICAL: Rituximab|RADIATION: Total-Body Irradiation|RADIATION: Yttrium Y-90 Ibritumomab Tiuxetan|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Three Nerves Versus Suprascapular Nerve Radiofrequency Combined With Hydrodissection in Adhesive Capsulitis
Status: NOT_YET_RECRUITING
Conditions: Analgesia
Interventions: PROCEDURE: 3 nerves pulsed radiofrequency with hydrodissection|PROCEDURE: suprascapular nerve pulsed radiofrequency with hydrodissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 12-Month Once-a-week HIIT Improves Body Adiposity and Liver Fat
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease|Central Obesity
Interventions: BEHAVIORAL: High-intensity Interval Training|BEHAVIORAL: Usual Care Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fresh to You: Multilevel Approaches in Low Income Housing to Increase F&V Intake
Status: COMPLETED
Conditions: Dietary Habits|Dietary Modification
Interventions: OTHER: Environmental Intervention|BEHAVIORAL: Educational Intervention|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: HSK7653 Metformin Add-on Study in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: HSK7653 10 mg Q2W|DRUG: HSK7653 25 mg Q2W|DRUG: Linagliptin 5 mg QD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Donor Umbilical Cord Blood Natural Killer Cells, Aldesleukin and Umbilical Cord Blood Transplant in Patients With Refractory Hematologic Cancers.
Status: TERMINATED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: filgrastim|BIOLOGICAL: natural killer cell (NK) therapy|DRUG: cyclophosphamide|DRUG: cyclosporine|DRUG: fludarabine phosphate|DRUG: methylprednisolone|DRUG: mycophenolate mofetil|PROCEDURE: Umbilical Cord Blood Transplantation (UCBT)|RADIATION: Total body irradiation (TBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Pemigatinib (INCB054828) in Subjects With Myeloid/Lymphoid Neoplasms With FGFR1 Rearrangement - (FIGHT-203)
Status: ACTIVE_NOT_RECRUITING
Conditions: MPN (Myeloproliferative Neoplasms)
Interventions: DRUG: Pemigatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fr1da Insulin Intervention
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage 1 Diabetes Mellitus, Type 1
Interventions: DRUG: Oral Insulin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: PA83-FhCMB Plant-Derived Recombinant Protective Antigen (rPA) Anthrax Vaccine
Status: COMPLETED
Conditions: Anthrax
Interventions: BIOLOGICAL: PA83-FhCMB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Reduced Volume of Neck Prophylactic Irradiation in Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma|Radiotherapy; Complications
Interventions: RADIATION: Intensity Modulated Radiation Therapy|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Application of Laparo-endoscopic Single-site Surgery and Natural Orifice Transluminal Endoscopic in Gynecology
Status: UNKNOWN
Conditions: Cervical Cancer, Endometrial Cancer，Endometrial Lesion & Adnexal Lesion，Ectopic Pregnancy & Infertility，Pelvic Obstructive Disorder & Genital Tract Deformity
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Compare the Efficacy of the Remineralization Agents on the White Enamel Lesions
Status: COMPLETED
Conditions: White Spot Lesions
Interventions: OTHER: Clinpro White Varnish (fluoride + calcium varnish)|OTHER: Curodont Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Pre-market Study to Evaluate the Performance and Safety of a Skin Preparation Device for Removal of Dry Crusty Skin
Status: COMPLETED
Conditions: Keratosis, Actinic|Actinic Lesion|Solar Keratosis/Sunburn|Hyperkeratosis|Hyperkeratotic Callus|Hyperkeratotic; Lesion|Hyperkeratotic Actinic Keratosis
Interventions: DEVICE: Investigational Skin Preparation Device|DEVICE: GMDN 47102 / Electrode Skin Abrasive Pad|DEVICE: UMDNS 13-230 / Biopsy punch (Dermal Curette)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of VEGF-A Targeting NIR-II Fluorescence Endoscopy in the Gastrointestinal Tract
Status: RECRUITING
Conditions: Gastrointestinal Carcinoma|Dysplasia|Gastrointestinal Polyp
Interventions: DRUG: Bev-ICG|DEVICE: NIR-II fluorescence endoscopy platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Optimizing Application And Support Of Immunization Information Systems (OASIS)
Status: COMPLETED
Conditions: Increase in Use of Immunization Registry|Increase in HPV Vaccination Rate
Interventions: OTHER: Reminder Recall Report|OTHER: Audit-Feedback/Immunization Forecasting Reports
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Rewarding Adherence Program - an Intervention Using Small Prizes Allocated by a Prize Drawing to Increase ARV Adherence
Status: COMPLETED
Conditions: HIV
Interventions: BEHAVIORAL: Small lottery prizes based on adherence|BEHAVIORAL: Small lottery prizes based on timely clinic visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 2 Open Label Randomized Study of Pirtobrutinib and Brexucabtagene Autoleucel in R/R MCL
Status: RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Pirtobrutinib|DRUG: Brexucabtagene Autoleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ZD6474, Cetuximab, and Irinotecan in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: ZD6474|DRUG: Cetuximab|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effects of Renal Impairment on the Pharmacokinetics, Safety and Tolerability of GC4419
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: GC4419
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Effect of Perampanel on Objective and Subjective Sleep in Subjects With Insomnia and Partial Onset Seizures
Status: WITHDRAWN
Conditions: Epilepsy, Partial
Interventions: DRUG: Perampanel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2a Respiratory Syncytial Virus (RSV) Human Challenge Study of Clesrovimab (MK-1654) in Healthy Participants (MK-1654-005)
Status: COMPLETED
Conditions: Respiratory Syncytial Viruses
Interventions: BIOLOGICAL: Clesrovimab|OTHER: Placebo|BIOLOGICAL: RSV-A Memphis 37b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multi-Detector CT Angiography With 3D Reconstruction Versus Digital Subtraction Angiography
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DIAGNOSTIC_TEST: Multi-Detector CT angiography|PROCEDURE: Trans-arterial chemoembolization and DSA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessing the Effectiveness of an Approach for Vocal Behaviors in Older People Living in Nursing Homes
Status: RECRUITING
Conditions: Behavioral Symptoms
Interventions: OTHER: Approach based on the meanings of vocal behaviours|OTHER: Usual practices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Transverse Abdominis Plane Block Versus Ilioinguinal-iliohypogastric Block For Analgesia Following Hysterectomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Transverse Abdominis Plane Block|PROCEDURE: Ilioinguinal-iliohypogastric block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of Sublingual Immunotherapy for Allergic Rhinitis Due to Artemisia Annua
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: AIT drops|DRUG: placebo drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: (Revival) Study to Investigate the Efficacy and Safety of Alkaline Phosphatase in Patients With Sepsis-Associated AKI
Status: TERMINATED
Conditions: Acute Kidney Injury Due to Sepsis
Interventions: BIOLOGICAL: Recombinant human alkaline phosphatase|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cetuximab Plus Paclitaxel as First Line for Recurrent and/or Metastatic SCCHN: Real World Data.
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Cetuximab|DRUG: Paclitaxel
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: G-Pen™ Compared to Lilly Glucagon for Hypoglycemia Rescue in Adults With Type 1 Diabetes
Status: COMPLETED
Conditions: Insulin Hypoglycemia|Type 1 Diabetes Mellitus|Severe Hypoglycemia
Interventions: DRUG: G-Pen|DRUG: Lilly Glucagon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Benefit of UHR-CT: Precision of Repeated Volume Measurements of Pulmonary Nodules
Status: COMPLETED
Conditions: Pulmonary Nodule, Solitary
Interventions: DEVICE: Precision Ultra-High-Resolution CT scanner|DEVICE: Genesis high-end CT scanner
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: GORE VIABAHN Endoprosthesis Versus Percutaneous Transluminal Angioplasty (PTA) to Revise AV Grafts in Hemodialysis
Status: COMPLETED
Conditions: Renal Failure|Hemodialysis
Interventions: DEVICE: GORE VIABAHN Endoprosthesis with PROPATEN Bioactive Surface|PROCEDURE: Percutaneous Transluminal Angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Delayed Rewarming for Neuroprotection in Infants Following Cardiopulmonary Bypass Surgery
Status: COMPLETED
Conditions: Post-Op Complication
Interventions: OTHER: Strict normothermia|DEVICE: Delayed Rewarming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Non-interventional, Retrospective Cohort Study to Explore OAC Treatment in Korea
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Apixaban|DRUG: Dabigatran|DRUG: Rivaroxaban|DRUG: warfarin|DRUG: Antiplatelets
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparing the Effectiveness of Two Approaches to Preventing Severe Hypoglycemia in Patients With Type 2 Diabetes (PHT2)
Status: COMPLETED
Conditions: Severe Hypoglycemia
Interventions: OTHER: Proactive Care Management|BEHAVIORAL: my hypo compass education program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intracranial Investigation of Neural Circuity Underlying Human Mood
Status: RECRUITING
Conditions: Depression|Epilepsy
Interventions: DEVICE: Brain Stimulation|DEVICE: sEEG Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Evaluate the Effect of Ticagrelor Versus Placebo in Reducing Vaso-Occlusive Crises Rate in Pediatric Patients With Sickle Cell Disease.
Status: WITHDRAWN
Conditions: Sickle Cell Disease
Interventions: DRUG: Brilinta|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a Behavioral Intervention for Older Advanced Cancer Patients and Their Caregivers
Status: RECRUITING
Conditions: Cancer, Advanced|Cognitive Impairment, Mild
Interventions: BEHAVIORAL: Dyadic Life Review (DLR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Pazopanib With or Without Abexinostat in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma (RENAVIV)
Status: RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Pazopanib|DRUG: Abexinostat|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Berberine in Non-alcoholic Steatohepatitis
Status: RECRUITING
Conditions: Non-alcoholic Steatohepatitis
Interventions: BEHAVIORAL: Lifestyle intervention|DRUG: Placebo|DRUG: Berberine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pegasys® Plus Ribavirin in Hemophilic Patients With Hepatitis C Virus Infection
Status: COMPLETED
Conditions: Hepatitis C|Hemophilia
Interventions: DRUG: PEGASYS® (Peginterferon Alfa-2a (40KD)) Plus COPEGUS® (Ribavirin)|DRUG: PEGASYS® (Peginterferon Alfa-2a (40KD)) Plus COPEGUS® (Ribavirin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a "Walk, Eat, & Breathe" Nursing Intervention For Patients With Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: BEHAVIORAL: Walk, Eat, & Breathe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Guided Self-Change Prevention Program for Alcohol Abuse in Adolescents in Educational Settings
Status: COMPLETED
Conditions: Alcohol Abuse or Dependence
Interventions: BEHAVIORAL: Guided Self-Change therapy (GSC)|BEHAVIORAL: Psychoeducation program about healthy habits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Autogenous Demineralized Dentin Graft for Ridge Preservation With and Without Injectable Platelet Rich Fibrin
Status: ACTIVE_NOT_RECRUITING
Conditions: Ridge Preservation|Alveolar Bone Loss|Dentin Graft
Interventions: PROCEDURE: injectable platelet rich fibrin with demineralized dentin graft|PROCEDURE: demineralized dentin graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Acceptability, and Feasibility of Enterade®
Status: TERMINATED
Conditions: Stunting|Environmental Enteric Dysfunction
Interventions: DIETARY_SUPPLEMENT: Enterade|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Phase I of SGM-101 in Patients With Cancer of the Colon, Rectum or Pancreas
Status: COMPLETED
Conditions: Colon Cancer|Rectum Cancer|Pancreas Cancer|Metastatic Colorectal Cancer|Recurrent Colorectal Carcinoma
Interventions: DRUG: SGM-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pre-probiotic Supplementation for Post-covid Fatigue Syndrome
Status: COMPLETED
Conditions: Long COVID
Interventions: DIETARY_SUPPLEMENT: Dietary Supplement: Experimental|DIETARY_SUPPLEMENT: Dietary Supplement: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vascular Supply Identification, Lesion Extension and Search for Tumor Similarity at a Distance by VTM in Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer Female
Interventions: DEVICE: VTM examination and breast biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rituximab and Bendamustine Hydrochloride, Rituximab and Ibrutinib, or Ibrutinib Alone in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage I Chronic Lymphocytic Leukemia|Stage II Chronic Lymphocytic Leukemia|Stage III Chronic Lymphocytic Leukemia|Stage IV Chronic Lymphocytic Leukemia
Interventions: DRUG: Bendamustine Hydrochloride|DRUG: Ibrutinib|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Aspirin and Postoperative Antiplatelets in Coronary Artery Bypass Grafting: The PAPA CABG Study
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Artery Bypass Grafting
Interventions: DRUG: Aspirin|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Videogame Assisted Pulmonary Rehabilitation in Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: Wiifit Nintendo video game|OTHER: Pulmonary rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SAKK 17/18 (ORIGIN) MPM & NSCLC >1st Line Gemci & Atezo Ph II
Status: COMPLETED
Conditions: Malignant Pleural Mesothelioma|Non-small Cell Lung Cancer
Interventions: DRUG: Gemcitabine|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TAK-981 in People With Advanced Solid Tumors or Cancers in the Immune System
Status: TERMINATED
Conditions: Neoplasms|Lymphoma|Hematologic Neoplasms
Interventions: DRUG: TAK-981
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the Combination of Aliskiren (300 mg) and Amlodipine (10 mg) Compared to Amlodipine (10 mg) Monotherapy in Patients With Moderate to Severe Hypertension
Status: COMPLETED
Conditions: Moderate to Severe Hypertension
Interventions: DRUG: Aliskiren/amlodipine 300/10 mg tablet|DRUG: Amlodipine 10 mg capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safer Care for Older People in (Residential) Environments
Status: COMPLETED
Conditions: Nursing Homes
Interventions: OTHER: modified IHI breakthrough series
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of GlideScope Videolaryngoscopy to Direct Laryngoscopy for Nasal Intubation
Status: COMPLETED
Conditions: Nasal Intubation
Interventions: DEVICE: GlideScope videolaryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Genetic Modulation of Working Memory in Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: ADHD
Interventions: DRUG: Methylphenidate, non-retard|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Investigation of the Effect of Kinesiotape Applied With Exercise on Muscle Oxygenation With Moxy Muscle Oxygen Monitor
Status: COMPLETED
Conditions: Healthy|Sedentary
Interventions: OTHER: exercise and kinesiotaping
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Strategies Using Darbepoetin Alfa to Avoid Transfusions in Chronic Kidney Disease
Status: COMPLETED
Conditions: Anemia in Chronic Kidney Disease Patients Not on Dialysis
Interventions: BIOLOGICAL: Darbepoetin alfa|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A PMCF Study in Patients With Acute or Chronic Aortic Dissection or Aortic Aneurysm Treated With E-vita OPEN NEO
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Dissection|Aortic Aneurysm
Interventions: DEVICE: Open repair
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Epidural Anesthesia for Gynecological Surgeries
Status: COMPLETED
Conditions: Epidural Analgesics for Comparison
Interventions: DRUG: Dexmedetomidine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Aprepitant + a 5HT3 + Dexamethasone in Patients With Germ Cell Tumors
Status: COMPLETED
Conditions: Germ Cell Tumors
Interventions: DRUG: Aprepitant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomized Phase II Trial of Letrozole With or Without Dasatinib as First and Second-line Treatment for Hormone Receptor-positive, HER2-negative Post-menopausal Breast Cancer That is Unresectable, Locally Recurrent or Metastatic
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Dasatinib|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of TP and TAC Regimens in Neoadjuvant Treatment of TNBC
Status: COMPLETED
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Docetaxel +doxorubicin+ cyclophosphamide|DRUG: Docetaxel +Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Trial of 4SCAR19 Cells in the Treatment of Relapsed and Refractory B Cell Leukemia
Status: UNKNOWN
Conditions: B Acute Lymphoblastic Leukemia
Interventions: GENETIC: prophylactic 4SCAR19 cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label Study to Evaluate Safety of Multiple Courses of IM Alefacept During Treatment of Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Alefacept
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ANV419 Alone or in Combination With Approved Treatment in Patients With Cutaneous Melanoma (OMNIA-1).
Status: RECRUITING
Conditions: Melanoma (Skin)|Cutaneous Melanoma|Adult Disease|Advanced Solid Tumor|Metastatic Melanoma
Interventions: DRUG: ANV419|DRUG: Pembrolizumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Utility of Ultrasound Compared to Cross-Sectional Imaging in the Follow-up of Patients With Renal Cell Carcinoma
Status: UNKNOWN
Conditions: Renal Cell Carcinoma
Interventions: DIAGNOSTIC_TEST: Ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study in Infants to Test Two Preparations (Freeze-dried or Liquid) of the Rotavirus Vaccine (HRV Vaccine).
Status: COMPLETED
Conditions: Infections, Rotavirus
Interventions: BIOLOGICAL: 2-dose oral live attenuated G1P[8] human rotavirus vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Umbilical Cord Mesenchymal Stem Cell Transplantation for Decompensated Hepatitis B Cirrhosis
Status: RECRUITING
Conditions: Liver Cirrhosis
Interventions: DRUG: UC-MSC infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vinpocetine Inhibits NF-κB-dependent Inflammation in Acute Ischemic Stroke Patients
Status: COMPLETED
Conditions: Stroke|Immunoregulation|Inflammation|Vinpocetine
Interventions: DRUG: vinpocetine|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Assess Adverse Events and Change in Disease Activity With Oral Cariprazine When Added to Antidepressant Therapies (ADTs) Compared to Placebo in Adult Participants With Generalized Anxiety Disorder (GAD) Who Have Had an Inadequate Response to ADTs Alone
Status: WITHDRAWN
Conditions: Generalized Anxiety Disorder
Interventions: DRUG: Cariprazine 0.75 mg/day|DRUG: Cariprazine 1.5 mg/day|DRUG: Cariprazine 3.0 mg/day|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SYNTAX Study: TAXUS Drug-Eluting Stent Versus Coronary Artery Bypass Surgery for the Treatment of Narrowed Arteries
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: Polymer-based Paclitaxel-Eluting TAXUS Express2-SR Stent|PROCEDURE: Coronary Artery Bypass Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Mirtazapine on Appetite in Advanced Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Cancer|Anorexia|Weight Loss|Insomnia
Interventions: DRUG: Mirtazapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Rehabilitation for Patients Undergoing Surgery for Lumbar Spinal Stenosis
Status: COMPLETED
Conditions: Lumbar Spinal Stenosis
Interventions: OTHER: Prehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Open-Label, Single-photon Emission Computed Tomography (SPECT) Study to Evaluate Serotonin and Dopamine Transporter Occupancy After Multiple Dose Administration of SEP-228432 to Achieve Steady State in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: SEP-228432|DRUG: SEP-228432
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Biomarker Research Study for Patients With FGFR-Mutant Bladder Cancer Receiving Erdafitinib
Status: TERMINATED
Conditions: Bladder Cancer|Urothelial Carcinoma|Transitional Cell Carcinoma|Platinum-Resistant Urothelial Carcinoma|Bladder Urothelial Carcinoma|FGFR Mutation|FGFR2 Gene Mutation|FGFR3 Gene Mutation|FGFR2 Amplification|Locally Advanced Urothelial Carcinoma|Metastatic Urothelial Carcinoma|Refractory Bladder Carcinoma|Refractory Bladder Urothelial Carcinoma
Interventions: DRUG: Balversa
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of a Virtual Reality-Based Sensory Stimulation Intervention in Preventing Delirium in Intensive Care Units
Status: NOT_YET_RECRUITING
Conditions: Delirium|Intensive Care Unit|Randomised Controlled Trial
Interventions: DEVICE: VR-based intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Rasagiline in Prodromal Parkinson's Disease
Status: NOT_YET_RECRUITING
Conditions: REM Sleep Behavior Disorder|Parkinson Disease|Synucleinopathies
Interventions: DRUG: Rasagiline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Plus Bevacizumab in Elderly Non-small Cell Lung Cancer Patients
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: BIOLOGICAL: bevacizumab, carboplatin and paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Rituximab Alternative Dosing Rate in Patients With Previously Untreated Diffuse Large B-cell or Follicular Non-Hodgkin's Lymphoma (RATE)
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Rituximab|DRUG: CHOP (cyclophosphamide, hydroxydaunorubicin [doxorubicin], Oncovin [vincristine], prednisone)|DRUG: CVP (cyclophosphamide, vincristine, prednisone)|DRUG: Analgesic/antipyretic and antihistamine drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sudarshan Kriya Yoga and Cardiac Autonomic Control in Patients With Anxiety-Depression Disorders
Status: COMPLETED
Conditions: Anxiety|Depression
Interventions: OTHER: SKY therapy|DRUG: usual drug therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Speech, Linguistic and Acoustic Markers in Parkinson's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson Disease|Cognitive Impairment, Mild|Speech
Interventions: DIAGNOSTIC_TEST: Cognitive Battery|BEHAVIORAL: Voice, Speech and Language Analysis|BEHAVIORAL: Questionnaires and Clinical Assessments|GENETIC: DNA Analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tongxinluo Capsule for Coronary Microvascular Disease
Status: NOT_YET_RECRUITING
Conditions: Coronary Microvascular Disease
Interventions: DRUG: Tongxinluo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Safety and Pharmacokinetic/Pharmacodynamic Characteristics of DW1903
Status: COMPLETED
Conditions: Gastritis
Interventions: DRUG: DW1903|DRUG: DW1903-R1|DRUG: DW1903-R2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomised Proof-of-Principle Trial Investigating Pharmacodynamics, Pharmacokinetics, and Safety of NNC0143-0406 in Subjects With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: NNC0143-0406|DRUG: Insulin Aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Mosapride Versus Placebo in the Treatment of Constipation-Predominant Irritable Bowel Syndrome
Status: TERMINATED
Conditions: Constipation-Predominant Irritable Bowel Syndrome
Interventions: DRUG: Mosapride Citrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clozapine for Cannabis Use in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Cannabis Abuse|Cannabis Dependence|Dual Diagnosis
Interventions: DRUG: Clozapine|DRUG: Risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of DuoTrav APS Versus DuoTrav
Status: WITHDRAWN
Conditions: Open-angle Glaucoma|Ocular Hypertension
Interventions: DRUG: DuoTrav APS|DRUG: DuoTrav
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Short Term Outcomes of Laparoscopic Intraperitoneal Onlay Mesh With Facial Repair(IPOM-plus) for Ventral Hernia.
Status: COMPLETED
Conditions: Hernia
Interventions: PROCEDURE: laparoscopic (IPOM) hernioplasty without repair|PROCEDURE: aparoscopic IIPOM hernioplasty with intracorporeal repair using proline 0 versus stratifix PDS|PROCEDURE: laparoscopic IPOM hernioplasty with transfacial closure using PDS LOOP 0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lacrimal Dilator-Facilitated vs Standard Sub-Tenon's Block
Status: COMPLETED
Conditions: to Compare Lacrimal Dilator-facilitated Incisionless and Standard STB With Wescott Scissors
Interventions: DEVICE: sub-Tenon's block with a lacrimal dilator group or a Wescott scissors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Watchman FLX Pro CT Pilot Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-valvular Atrial Fibrillation (AF)
Interventions: DEVICE: Left atrial appendage closure device WM FLX Pro
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Clinical Study of Anti-CD19 CAR NK Cells in the Treatment of Systemic Lupus Erythematosus
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus (SLE)
Interventions: DRUG: anti-CD19 CAR NK cells (KN5501)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exteriorized Versus In Situ Uterine Repair at Cesarean Delivery
Status: COMPLETED
Conditions: Vomiting|Nausea|Pain|Hypotension|Tachycardia
Interventions: DRUG: Spinal Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Different Music Listened During Retinopathy Examination to Premature Infants
Status: RECRUITING
Conditions: Retinopathy of Prematurity|Newborn
Interventions: OTHER: Research processes;
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study Evaluating the Efficacy and Safety of VX-445/Tezacaftor/Ivacaftor in Cystic Fibrosis Subjects, Homozygous for F508del
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: ELX/TEZ/IVA|DRUG: TEZ/IVA|DRUG: IVA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SPI-1005 for the Treatment of Meniere's Disease
Status: COMPLETED
Conditions: Meniere Disease|Ménière
Interventions: DRUG: Ebselen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study on the Antiviral Activity and Safety of BILR 355 BS in HIV-1 Infected, NNRTI-treated Patients
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: BILR 355 BS|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Use of Angiotensin-(1-7) in COVID-19
Status: COMPLETED
Conditions: Infection, Coronavirus|Respiratory Failure
Interventions: DRUG: Angiotensin-(1-7)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of SJX-653 in Postmenopausal Women With Moderate to Severe Vasomotor Symptoms
Status: TERMINATED
Conditions: Hot Flashes
Interventions: DRUG: SJX-653|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ConnectEd: A Randomized Controlled Trial Connecting Through Educational Training
Status: COMPLETED
Conditions: Sexual Violence
Interventions: BEHAVIORAL: Online Bystander Training|BEHAVIORAL: Online Substance Abuse Training|BEHAVIORAL: In-Person Bystander Training|BEHAVIORAL: In-Person Combination Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Outcomes Study of Hyperinsulinemic Glucose Control in Cardiac Surgery
Status: COMPLETED
Conditions: Cardiac Surgery
Interventions: OTHER: Hyperinsulinemic-normoglycemic clamp|OTHER: insulin at the standard of care levels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Dose Optimisation of Stavudine for the Treatment of HIV Infection
Status: COMPLETED
Conditions: Acquired Immune Deficiency Syndrome|Human Immunodeficiency Virus
Interventions: DRUG: Stavudine|DRUG: Tenofovir Disoproxil Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Internet-based Treatment for Insomnia
Status: COMPLETED
Conditions: Psychophysiologic Insomnia
Interventions: BEHAVIORAL: CBT for insomnia SHUTi|BEHAVIORAL: passive patient education/sleep hygiene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT