pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Impact of Intravascular Fluid Resuscitation and Whole Blood Viscosity for Cardiac Surgery
Status: UNKNOWN
Conditions: Cardiac Surgery
Interventions: DRUG: Intravenous Crystalloid|DRUG: Intravenous HES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Value of Bronchoscopic Lung Volume Reduction by Endobronchial Valves in Patients With Single Lung Transplantation and Overinflation of the Native Lung
Status: UNKNOWN
Conditions: Native Lung Overinflation in Patients That Underwent Single Lung Transplantation Due to Emphysema
Interventions: DEVICE: lung volume reduction using the Zephyr device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Gemcitabine, Pembrolizumab and IMM-101 as First Line Treatment in Patients With Metastatic Pancreatic Cancer
Status: RECRUITING
Conditions: Neoplasms Pancreatic
Interventions: DRUG: IMM-101, Pembrolizumab, Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhalative Sedation in ICU With Sevoflurane Via Anaesthetic Conserving Device Compared to Propofol
Status: COMPLETED
Conditions: Recovery From Sedation|Sevoflurane Consumption|Renal Function|Hepatic Function|Cardioprotection
Interventions: DRUG: Sevoflurane|DRUG: Propofol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dietary Modulation of Intestinal Microbiota as Trigger of Liver Health: Role of Bile Acids - "A Diet for Liver Health"
Status: COMPLETED
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: DIETARY_SUPPLEMENT: oatmeal flakes with prebiotic food supplements|DIETARY_SUPPLEMENT: millet flakes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Aerobic Training Effects on Motor and Cognitive Performances in MS: an Exploratory Study With Structural and Functional MRI
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Aerobic training compared to conventional motor training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Mandibular Advancement Device Treating OSAHS on Primary Prevention of Ischemic Stroke
Status: COMPLETED
Conditions: Sleep Apnea Syndromes|Atherosclerosis|Carotid Plaque
Interventions: DEVICE: oral appliance treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Inhibition Techniques Applied on Trigger Points of Supraspinatus Muscle on Echogenicity and Patients' Pain
Status: NOT_YET_RECRUITING
Conditions: Shoulder Pain
Interventions: OTHER: inhibition technique|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oncolytic Adenovirus Coding for TNFa and IL2 (TILT-123) With Pembrolizumab or Pembrolizumab and Pegylated Liposomal Doxorubicin as Treatment for Ovarian Cancer.
Status: RECRUITING
Conditions: Platinum-refractory Ovarian Carcinoma|Platinum-resistant Ovarian Cancer|Platinum-Resistant Fallopian Tube Carcinoma|Platinum-Resistant Primary Peritoneal Carcinoma|Platinum-Refractory Fallopian Tube Carcinoma|Platinum-Refractory Primary Peritoneal Carcinoma|Platinum-Sensitive Ovarian Cancer in Which the Participant Has Allergy or Severe Intolerance to Carboplatin and/or Cisplatin|Platinum-Sensitive Fallopian Tube Carcinoma in Which the Participant Has Allergy or Severe Intolerance to Carboplatin and/or Cisplatin|Platinum-Sensitive Primary Peritoneal Carcinoma in Which the Participant Has Allergy or Severe Intolerance to Carboplatin and/or Cisplatin
Interventions: BIOLOGICAL: TILT-123|BIOLOGICAL: pembrolizumab|DRUG: pegylated liposomal doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Follow up Study of Crocin on Cardiac Function Protection in Patients With Breast Cancer Undergoing Neoadjuvant Chemotherapy Based on Color Doppler Ultrasound Combined With Myocardial Zymogram
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Crocin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Indo-cyanine Green (ICG) in Paediatric Oncology MIS
Status: COMPLETED
Conditions: Pediatric Renal Tumor|Metastatic Osteosarcoma|Metastatic Ewing Sarcoma|Pulmonary Metastasis|Rhabdomyosarcoma|Non-Rhabdo. Soft Tissue Sarcoma
Interventions: DRUG: Indocyanine green
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Effects of Sotagliflozin 400 and 200 mg on Glucose Control in Participants With Type 2 Diabetes, Severe Impairment of Kidney Function and Inadequate Blood Sugar Control
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Chronic Kidney Disease Stage 4
Interventions: DRUG: Placebo|DRUG: Sotagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ranibizumab Prn Treatment Compared to Aflibercept Bimonthly Intravitreal Injections on Retinal Thickness Stability in Patients With Wet AMD
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: Ranibizumab|DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Versus Balance Beam on Spastic Hemiplegic Cerebral Palsy
Status: UNKNOWN
Conditions: Balance Problems in Spastic Hemiplegic Children|Walking Performance in Spastic Hemiplegic Children
Interventions: DEVICE: Virtual Reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Open Versus Closed Wedge Distal Femoral Varus Osteotomy for the Valgus Knee. Indications, Clinical and Radiological Outcome
Status: COMPLETED
Conditions: Valgus Malalignment of the Knee
Interventions: OTHER: Data collection from routine medical records
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Minimum Effective Volume Of Local Anesthetic İn USG Guided Axillary Approach Brachial Plexus Block
Status: COMPLETED
Conditions: Underdosing of Local Anesthetics
Interventions: PROCEDURE: bupivakain % 0,5
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Use of Tamsulosin to Reduce the Incidence and Duration of Postoperative Urinary Retention Following Spine Surgery
Status: TERMINATED
Conditions: Postoperative Urinary Retention
Interventions: DRUG: Tamsulosin hydrochloride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Diet and Other Non Pharmacological Interventions to Reduce Cardiovascular Risk in Hypertensive Patients
Status: UNKNOWN
Conditions: Hypertension
Interventions: BEHAVIORAL: DIET CHANGE|BEHAVIORAL: PHYSICAL ACTIVITY|OTHER: INTEGRATIVE PRACTICES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eosinophilic Oesophagitis Assessment With String Testing
Status: RECRUITING
Conditions: Eosinophilic Esophagitis
Interventions: DEVICE: CEST - coiled oesophageal string test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Plecanatide Irritable Bowel Syndrome With Constipation Study (IBS-C)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome Characterized by Constipation
Interventions: DRUG: Plecanatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Afatinib as Cancer Therapy for Exocrine Pancreatic Tumours
Status: UNKNOWN
Conditions: Focus of Study Instead
Interventions: DRUG: Gemcitabine|DRUG: Afatinib|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nanocurcumin for Prostate Cancer Patients Undergoing Radiotherapy (RT)
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DRUG: Curcumin|RADIATION: RT|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nebulized Hypertonic Saline for Bronchiolitis
Status: COMPLETED
Conditions: Bronchiolitis
Interventions: DRUG: Nebulized 3% saline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotic Lactobacillus Rhamnosus GG for Pediatric Atopic Dermatitis
Status: UNKNOWN
Conditions: Atopic Dermatitis
Interventions: DIETARY_SUPPLEMENT: Lactobacillus rhamnosus GG|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of Oral CL-H1T in the Treatment of Acute Migraine Pain
Status: COMPLETED
Conditions: Migraine|Pain|Nausea|Vomiting|Aura
Interventions: DRUG: Arm 1: CL-H1T|DRUG: Arm 2: CL-H1T|DRUG: Arm 3: Sumatriptan Succinate 100 mg capsule|DRUG: Arm 4: Promethazine HCl 18.75 mg|DRUG: Arm 5: Promethazine HCl 37.5 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Hedgehog Pathway Inhibitor GDC-0449 in Healthy Female Subjects of Non-Childbearing Potential
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GDC-0449 oral capsules (non-labeled)|DRUG: GDC-0449 IV injection (labeled)|DRUG: CDC-0449 oral suspension (labeled)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carbohydrate Intake and Gut Hormone Release During Exercise
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Maltodextrin (carbohydrate)|OTHER: Exercise|OTHER: Rest|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Using Shade Blocker Versus Chameleon Effect of Two Single Shade of Resin Composite in Class IV Restorations
Status: UNKNOWN
Conditions: Discoloration, Tooth
Interventions: DIAGNOSTIC_TEST: single-shade universal resin composite (omnichroma) with blocker( omnichroma blocker)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Efficacy of 'BRFS-18G-S100WH' as Compared to 'MINT Lift FINE+' in Subject With Nasolabial Folds
Status: RECRUITING
Conditions: Nasolabial Folds
Interventions: DEVICE: BRFS-18G-S100WH|DEVICE: MINT Lift FINE+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enfortumab Vedotin for the Treatment of Patients With Metastatic or Unresectable Squamous Cell Carcinoma of the Penis
Status: RECRUITING
Conditions: Metastatic Penile Squamous Cell Carcinoma|Stage III Penile Cancer AJCC v8|Stage IV Penile Cancer AJCC v8|Unresectable Penile Squamous Cell Carcinoma
Interventions: DRUG: Enfortumab Vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Povorcitinib on the QT/QTc Interval in Healthy Participants
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: Povorcitinib|DRUG: Placebo|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab on Background Topical Corticosteroids Therapy in Participants Aged 12 Years and Older With Moderate-to-severe AD Who Have Had an Inadequate Response to Prior Biologic Therapy or an Oral JAK Inhibitor
Status: RECRUITING
Conditions: Dermatitis Atopic
Interventions: DRUG: Amlitelimab|DRUG: Placebo|DRUG: Topical corticosteroids|DRUG: Topical tacrolimus or pimecrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Negative Symptoms and Cognitive Function After Administration of Antipsychotics in Healthy Volunteer
Status: COMPLETED
Conditions: Normal Volunteers
Interventions: DRUG: risperidone|DRUG: aripiprazole|DRUG: haloperidol|DRUG: amisulpride|DRUG: lactose
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Extension Study of NKTR-102 in Cancer Patients Previously Enrolled in NKTR-102 Studies
Status: COMPLETED
Conditions: Malignant Solid Tumor
Interventions: DRUG: NKTR-102 145 mg/m2|DRUG: NKTR-102 120 mg/m2|DRUG: NKTR-102 95 mg/m2|DRUG: NKTR-102 50 mg/m2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closed-loop Double-vasopressor Automated System to Treat Hypotension During Spinal Anaesthesia for Caesarean Section
Status: COMPLETED
Conditions: Hypotension
Interventions: DEVICE: Vasopressor automated delivery system|DRUG: Phenylephrine|DRUG: Ephedrine|DEVICE: Manual vasopressor delivery system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Artery Conditions of 'At-risk' Asian People Not on Lipid-lowering Drugs
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: PROCEDURE: Measurement of the Carotid Intima Media thickness|BIOLOGICAL: Blood sample testing for hs-CRP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: SCREENING
Clinical trial: Role of Eltrombopag as First Line Therapy in Primary Immune Thrombocytopenia.
Status: NOT_YET_RECRUITING
Conditions: Primary Immune Thrombocytopenia
Interventions: DRUG: Eltrombopag 25 MG|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fistulotomy With Marsupialization Versus Fistulectomy With Wound Sutures in Simple Anal Fistula
Status: COMPLETED
Conditions: Fistula in Ano
Interventions: PROCEDURE: fistulotomy and marsupialization|PROCEDURE: fistulectomy and wound closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Investigate the Efficacy of a Supplement to Improve and Maintain Cognitive Function and Memory
Status: ACTIVE_NOT_RECRUITING
Conditions: Cognitive Decline|Cognitive Function
Interventions: DIETARY_SUPPLEMENT: MindMD Supplement|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing Trametinib as a Potential Targeted Treatment in Cancers With NF1 Genetic Changes (MATCH-Subprotocol S1)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lymphoma|Advanced Malignant Solid Neoplasm|Hematopoietic and Lymphoid Cell Neoplasm|Refractory Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Multiple Myeloma
Interventions: DRUG: Trametinib Dimethyl Sulfoxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MK2206 in Locally Advanced or Metastatic Solid Tumors (2206-007)
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: MK2206 every other day|DRUG: MK2206 once weekly
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ixabepilone in Treating Patients With Metastatic or Recurrent Squamous Cell Cancer of the Head and Neck
Status: COMPLETED
Conditions: Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma|Recurrent Metastatic Squamous Neck Cancer With Occult Primary|Recurrent Salivary Gland Cancer|Recurrent Squamous Cell Carcinoma of the Hypopharynx|Recurrent Squamous Cell Carcinoma of the Larynx|Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity|Recurrent Squamous Cell Carcinoma of the Oropharynx|Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Recurrent Verrucous Carcinoma of the Larynx|Recurrent Verrucous Carcinoma of the Oral Cavity|Salivary Gland Squamous Cell Carcinoma|Stage IV Squamous Cell Carcinoma of the Hypopharynx|Stage IVA Salivary Gland Cancer|Stage IVA Squamous Cell Carcinoma of the Larynx|Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVA Squamous Cell Carcinoma of the Oropharynx|Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVA Verrucous Carcinoma of the Larynx|Stage IVA Verrucous Carcinoma of the Oral Cavity|Stage IVB Salivary Gland Cancer|Stage IVB Squamous Cell Carcinoma of the Larynx|Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVB Squamous Cell Carcinoma of the Oropharynx|Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVB Verrucous Carcinoma of the Larynx|Stage IVB Verrucous Carcinoma of the Oral Cavity|Stage IVC Salivary Gland Cancer|Stage IVC Squamous Cell Carcinoma of the Larynx|Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVC Squamous Cell Carcinoma of the Oropharynx|Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVC Verrucous Carcinoma of the Larynx|Stage IVC Verrucous Carcinoma of the Oral Cavity|Tongue Cancer
Interventions: DRUG: ixabepilone|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Dental and Skeletal Effect of TPA and Nance as a Space Maintainers in Children: A Prospective Clinical Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Malocclusion
Interventions: DEVICE: TPA|DEVICE: Nance appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Assess Efficacy of Vardenafil 10mg in Erectile Dysfunction Within Intake of 6 Hours
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Levitra (Vardenafil, BAY38-9456)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of the Mindfulness-based Cognitive Therapy (MBCT) on Sexual Functioning in Epileptic Women
Status: COMPLETED
Conditions: Epilepsy|Sexual Dysfunction
Interventions: BEHAVIORAL: Mindfulness-Based Sex Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Effectiveness and Safety of CNTO 136 in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: CNTO 136 100 mg|DRUG: CNTO 136 50 mg|DRUG: CNTO 136 25 mg|DRUG: Placebo|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: New Tool of Subjective and Objective Functional Evaluation and the Quality of Life After Arthroplastic Surgery of the Hip and the Knee Assisted or Not by Computer and Mini-invasive Arthroplasty
Status: TERMINATED
Conditions: Hip Arthritis|Knee Arthritis
Interventions: PROCEDURE: Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of LY900014 in Japanese Participants With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: LY900014|DRUG: Insulin Lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: LGG for Prevention of Infectious Complications During PPI Treatment in Children
Status: UNKNOWN
Conditions: Gastroesophageal Reflux Disease|Gastrointestinal Infections|Respiratory Tract Infections
Interventions: DIETARY_SUPPLEMENT: Lactobacillus GG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Collagen Supplementation on Tendinopathy
Status: UNKNOWN
Conditions: Tendinopathy
Interventions: DIETARY_SUPPLEMENT: Hydrolyzed collagen|OTHER: Heavy slow resistance training|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of BioTraceIO 360 for Planning, Monitoring and Assessment of Liver Tissue Ablation Procedures
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma|Metastatic Liver Cancer
Interventions: DEVICE: BioTraceIO 360
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: An Open-Label Immunogenicity and Pharmacokinetics Study of Daclizumab High Yield Process Prefilled Syringe in Relapsing Remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing-Remitting Multiple Sclerosis
Interventions: DRUG: Midazolam|OTHER: Caffeine|DRUG: S-warfarin|OTHER: Vitamin K|DRUG: Omeprazole|DRUG: Dextromethorphan|BIOLOGICAL: BIIB019 (Daclizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prevention of Acute Kidney Injury in Cardiac Surgery Patients
Status: COMPLETED
Conditions: Kidney Injury
Interventions: DRUG: 0.9% Sodium Chloride (Placebo)|DRUG: Sodium Bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase Ia, Dose Escalation Study of Humanized Anti-VEGF Monoclonal Antibody (Sevacizumab) Injection in Patients With Advanced or Metastatic Solid Tumors
Status: UNKNOWN
Conditions: Advanced Solid Tumors|Metastatic Solid Tumors
Interventions: DRUG: Sevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RAD001 Plus Docetaxel in Patients With Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Docetaxel|DRUG: RAD001|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Soticlestat in Healthy Adult Nondependent Recreational Drug Users With Central Nervous System (CNS) Depressant Experience
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Soticlestat 300 mg|DRUG: Soticlestat 600 mg|DRUG: Soticlestat 900 mg|DRUG: Alprazolam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Testing the Efficacy of an Online Alcohol Intervention in a Workplace Setting
Status: COMPLETED
Conditions: Hazardous Drinking|Harmful Drinking
Interventions: BEHAVIORAL: Online screening and feedback|BEHAVIORAL: Online booklet.|BEHAVIORAL: Online multi session follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety Study of CC312 in Adult Patients With Relapsed/Refractory CD19 Positive B-cell Hematologic Malignancies
Status: RECRUITING
Conditions: Non-hodgkin Lymphoma|Acute Lymphoblastic Leukaemia|Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: CC312
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of VI-0521 on Ambulatory Blood Pressure (ABPM) in Overweight or Obese Subjects
Status: COMPLETED
Conditions: Blood Pressure
Interventions: DRUG: VI-0521|DRUG: Phentermine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Ultrasound-Guided Lymph Node Biopsy in Axillary Staging of Breast Cancer.
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: PROCEDURE: Ultrasound-guided axillary lymph nodes FNAC and\or CNB.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: CARDS Is Designed To Show If Lowering Cholesterol With Atorvastatin In Type 2 Diabetics Without CV Disease Reduces The Risk Of CV Events
Status: COMPLETED
Conditions: Major Coronary Event|Cerebrovascular Accident|Coronary Artery Bypass Graft|Angina, Unstable|Revascularization
Interventions: DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of GSK1358820 in Japanese Patients With Urinary Incontinence Due to Neurogenic Detrusor Overactivity
Status: COMPLETED
Conditions: Urinary Bladder, Overactive
Interventions: DRUG: GSK1358820|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ferumoxytol-Enhanced MRI in Imaging Lymph Nodes in Patients With Stage IIB-IIIC Esophageal Cancer
Status: WITHDRAWN
Conditions: Stage IIB Esophageal Cancer AJCC v7|Stage III Esophageal Cancer AJCC v7|Stage IIIA Esophageal Cancer AJCC v7|Stage IIIB Esophageal Cancer AJCC v7|Stage IIIC Esophageal Cancer AJCC v7
Interventions: DRUG: Ferumoxytol|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: MARGetuximab Or Trastuzumab (MARGOT)
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Stage II Breast Cancer|Stage III Breast Cancer|HER2-positive Breast Cancer
Interventions: DRUG: Paclitaxel|DRUG: Pertuzumab|DRUG: Margetuximab|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studying Blood Samples in Young Patients With Cytopenia After a Donor Stem Cell Transplant
Status: UNKNOWN
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: GENETIC: polymerase chain reaction|OTHER: flow cytometry|OTHER: laboratory biomarker analysis|PROCEDURE: allogeneic hematopoietic stem cell transplantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Resistance Training Intervention to Improve Physical Function in Patients With Pancreatic Cancer Receiving Combination Chemotherapy or Have Undergone Surgery, PancStrength Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Pancreatic Adenocarcinoma|Pancreatic Adenocarcinoma|Stage III Pancreatic Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8
Interventions: OTHER: Educational Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|OTHER: Resistance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Upper Extremity Training for Improving Balance Control Post-Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Traditional Physical Therapy Program|DEVICE: ArmeoSpring Virtual Reality Device (Upper Extremity Training Device with Virtual Reality Technology)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colistin-rifampin Combination and Colistin Monotherapy in Extensively Drug-resistant Acinetobacter Baumannii
Status: COMPLETED
Conditions: Colistin|Rifampin|Acinetobacter Infections
Interventions: DRUG: colistin and rifampin combination therapy|DRUG: colistin monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post COVID-19 Syndrome and the Gut-lung Axis
Status: ACTIVE_NOT_RECRUITING
Conditions: Covid19
Interventions: DIETARY_SUPPLEMENT: Omni-Biotic Pro Vi 5|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Fluocinolone Acetonide Intravitreal Inserts in Geographic Atrophy
Status: TERMINATED
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: Fluocinolone Acetonide|DRUG: Fluocinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Urethrocutaneous Fistula Rate After Double Dartos and Single Dartos Tubularized Incised Plate Urethroplasty
Status: COMPLETED
Conditions: Hypospadias
Interventions: PROCEDURE: Group B|PROCEDURE: Group A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypofractionated Versus Conventionally Fractionated Radiotherapy for Initial Distant Metastases Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma
Interventions: RADIATION: Hypofraction radiation|RADIATION: Standard dose IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A New Ultrasonographic Tool to Assess Pulmonary Strain in Patients Under One-lung Ventilation.
Status: COMPLETED
Conditions: Ventilator-Induced Lung Injury|Mechanical Ventilation Complication
Interventions: PROCEDURE: Lung ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Multicenter Comparison of Early and Late Vascular Responses to Everolimus-eluting Cobalt-CHromium Stent
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: CoCr-EES
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Pediatric Patients With Advanced-Stage Large Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|DRUG: cytarabine|DRUG: doxorubicin hydrochloride|DRUG: leucovorin calcium|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: prednisone|DRUG: vincristine sulfate|RADIATION: low-LET cobalt-60 gamma ray therapy|RADIATION: low-LET electron therapy|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Usability and Clinical Effectiveness of an Interpretable Deep Learning Framework for Post-Hepatectomy Liver Failure Prediction
Status: RECRUITING
Conditions: Post-hepatectomy Liver Failure|Hepatocellular Carcinoma|Artificial Intelligence
Interventions: OTHER: The explanation of deep learning framework (VAE-MLP) , including counterfactual explanations and layerwise relevance propagation|OTHER: The model prediction|OTHER: The model prediction and the explanation of deep learning framework (VAE-MLP) , including counterfactual explanations and layerwise relevance propagation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Study of Rituximab Versus Combination of Rituximab and Intravenous Cyclophosphamide in Severe Pemphigus
Status: UNKNOWN
Conditions: Pemphigus
Interventions: DRUG: Rituximab and Cyclophosphamide IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Reaching and Treating Lesbian, Gay, Bisexual, and Transgender (LGBT) Cigarette Smokers
Status: COMPLETED
Conditions: Cigarette Smoking
Interventions: BEHAVIORAL: Mail-based Self-help plus Internet-based Smoking Treatment|BEHAVIORAL: Self-Help Manual plus Telephone counseling|BEHAVIORAL: Self-Help Manual|BEHAVIORAL: Self-Help Manual plus Internet-based Intervention plus Telephone Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Medicine for Advanced Biliary Cancer Patients
Status: RECRUITING
Conditions: Biliary Tract Neoplasms
Interventions: DRUG: Futibatinib|DRUG: Ivosidenib|DRUG: Zanidatamab|DRUG: Trastuzumab|DRUG: Neratinib|DRUG: Encorafenib|DRUG: Binimetinib|DRUG: Niraparib|DRUG: Cisplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Antimicrobial Photodynamic Therapy on Regeneration of Class II Furcation Lesions
Status: COMPLETED
Conditions: Periodontitis, Chronic|Periodontal Diseases|Periodontal Bone Loss
Interventions: PROCEDURE: Scaling and root planing|DRUG: Toluidine Blue O
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modulation of Reproductive Microbiota by Ligilactobacillus Salivarius CECT5713
Status: COMPLETED
Conditions: Infertility Unexplained
Interventions: DIETARY_SUPPLEMENT: Ligilactobacillus salivarius CECT5713|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparing Strategies for Translating Self-management Support Into Primary Care
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Self-management support education|BEHAVIORAL: Connection to Health Interactive Behavior Change Technology|BEHAVIORAL: Connection to Health plus Coaching (CTH+C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Effect of Output on Newly Developed Adhesives
Status: COMPLETED
Conditions: Ileostomy - Stoma
Interventions: OTHER: Standard hydrocolloid adhesive|OTHER: P-4|OTHER: P-15|OTHER: P-16
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Theranostic Tool During Erlotinib Treatment in Non-small Cell Lung Cancer Patient
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer Metastatic or Non-small Cell Lung Cancer Recurrent|No EGFR Activating Mutation
Interventions: RADIATION: 18F-FLT-TEP|RADIATION: 18F-FDG-TEP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: EpSSG (European Soft Tissue Sarcoma Study Group) Protocol for Non-Metastatic Rhabdomyosarcoma in Children
Status: UNKNOWN
Conditions: Rhabdomyosarcoma
Interventions: DRUG: doxorubicin, cytoxan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Study of UB-312 in Healthy Participants and Parkinson's Disease Patients
Status: COMPLETED
Conditions: Parkinson's Disease|Parkinsonism
Interventions: BIOLOGICAL: UB-312|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Lumbopelvic Manipulation on Neuromuscular Activity of Back & Hip Muscles in Adults With Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: OTHER: Lumbopelvic Manipulation|OTHER: Sham manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clofarabine vs Clofarabine in Plus With Low-Dose Ara-C in Previously Untreated Patients With Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndromes (MDS).
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: Clofarabine|DRUG: Ara-C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Comparison of Pharmacodynamics and Pharmacokinetics of Insulin Aspart, Biphasic Insulin Aspart 30, 50 and 70.
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: NovoRapid, NovoMix 30, Bifasisk Insulin Aspart 50, BIAsp70
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of D064 and D702 Combination Therapy Versus D064 or D702 Monotherapy
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: D064 and D702, QD|DRUG: D064 and Placebo of D702, QD|DRUG: Placebo of D064 and D702, QD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Fimasartan for Early Diastolic Heart Failure
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Fimasartan|DRUG: Antihypertensive treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyoscine Butyl-bromide Versus Ondansetron for Nausea and Vomiting During Cesarean Section Under Spinal Anesthesia
Status: COMPLETED
Conditions: Vomiting
Interventions: DRUG: Hyoscine N Butylbromide|DRUG: Ondansetron|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Pivotal Study of a Facet Replacement System to Treat Spinal Stenosis
Status: COMPLETED
Conditions: Lumbar Spinal Stenosis
Interventions: DEVICE: Non-randomized ACADIA® Facet Replacement System|DEVICE: Randomized ACADIA® Facet Replacement System|DEVICE: Randomized Instrumented posterolateral fusion (PLF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of SIC 8000 in Subjects Undergoing Endoscopic Mucosal Resection (EMR) of Colonic Lesions Equal to or Larger Than 2 cm
Status: COMPLETED
Conditions: Adenomas
Interventions: PROCEDURE: Endoscopic Mucosal Resection of large colon polyps (greater than or equal to 20 mm in size)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Osteoblastic Activity With 18F-Fluoride in Aortic Bioprosthesis Structural Valve Dysfunction (SVD)
Status: COMPLETED
Conditions: Aortic Bioprosthesis Structural Valve Dysfunction
Interventions: OTHER: 18F-Fluoride PET-CT ; CT calcium scoring ; 18F-FDG PET-CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Assessment of CR6261, a Monoclonal Antibody Against the Influenza A Virus
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: CR6261 2 mg/kg|BIOLOGICAL: CR6261 5 mg/kg|BIOLOGICAL: CR6261 15 mg/kg|BIOLOGICAL: CR6261 30 mg/kg|BIOLOGICAL: CR6261 50 mg/kg|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preemptive Erector Spinae Plane Block Versus Serratus Anterior Plane Block in MRM
Status: COMPLETED
Conditions: Modified Radical Mastectomy
Interventions: PROCEDURE: Erector spinae plane group|PROCEDURE: Serratus anterior plane group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Paclitaxel and BMS-214662 in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: BMS-214662|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ALN-HBV in Healthy Adult Volunteers and Non-cirrhotic Patients With Chronic Hepatitis B Virus (HBV) Infection
Status: TERMINATED
Conditions: Hepatitis B|Chronic Hepatitis B|Hepatitis B, Chronic|Hepatitis B Infection|HBV
Interventions: DRUG: ALN-HBV|DRUG: Sterile Normal Saline (0.9% NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of MEDI-507, Administered by Injection to Adults With Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: MEDI-507|OTHER: Placebo|DRUG: MEDI-507|DRUG: MEDI-507
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Topical Application of Tranexamic Acid Reduces Postoperative Blood Loss in Total Hip Arthroplasty
Status: UNKNOWN
Conditions: Hip Replacement|Postoperative Hemorrhage
Interventions: DRUG: Tranexamic Acid|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Saline Instillation Before Tracheal Suctioning and the Incidence of Ventilator Associated Pneumonia
Status: COMPLETED
Conditions: Mechanical Ventilation|Critically Ill Patients
Interventions: PROCEDURE: Saline Instillation before Tracheal Suctioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: The Difference Between Using Local and General Dexamethasone in Arthroscopic Anterior Cruciate Ligament Repair
Status: COMPLETED
Conditions: ACL Injury
Interventions: DRUG: Dexamethasone injection|DRUG: Bupivacaine 0.375% Injectable Solution|DRUG: Bupivacaine 0.5% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: L-arginine for Prevention of Kidney Damage in Liver Transplant Recipients
Status: COMPLETED
Conditions: Liver Transplant Recipients
Interventions: DIETARY_SUPPLEMENT: L-arginine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Inhalation Sedation Compared With Propofol on the Sepsis-related Acute Respiratory Distress Syndrome Course
Status: UNKNOWN
Conditions: ARDS
Interventions: DRUG: Inhalation Sedation|DRUG: Intravenous Sedation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Genetic Counseling for Female First Degree Relatives of Individuals With Mental Illness
Status: COMPLETED
Conditions: Schizophrenia|Bipolar Disorder|Schizoaffective Disorder
Interventions: BEHAVIORAL: Genetic Counseling|BEHAVIORAL: Genetic Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Stress Coping Strategy on Perceived Stress Levels and Performance During a Simulated Cardiopulmonary Resuscitation
Status: COMPLETED
Conditions: Cardiopulmonary Resuscitations
Interventions: BEHAVIORAL: Stress coping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Dose Escalation Study of TriN2755 in Advanced Solid Tumors and Sarcomas
Status: UNKNOWN
Conditions: Neoplasms
Interventions: DRUG: TRIN2755|DRUG: TRIN2755
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Hepatitis B Virus Infection in Zambia
Status: ACTIVE_NOT_RECRUITING
Conditions: HBV|Fibrosis, Liver|Cirrhosis, Liver|Alcoholic Hepatitis|Hepatocellular Carcinoma|Hepatitis, Delta
Interventions: OTHER: Standard of care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety and Pharmacokinetics With MEDI8367 Administered in Healthy Subjects, and in Subjects With Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: MEDI8367|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT