pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Early Drain Removal Versus Standard Drain Management After Distal Pancreatectomy (Early-Dist)
Status: COMPLETED
Conditions: Pancreas Disease|Complication,Postoperative|PROMs|Pancreatic Fistula
Interventions: PROCEDURE: Early drain removal|PROCEDURE: Standard drain removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Single Dose PG102 in Patients With Active Psoriatic Arthritis
Status: TERMINATED
Conditions: Arthritis, Psoriatic
Interventions: DRUG: PG102|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multimodal Imaging in Rectal Cancer & Pancreatic Cancer
Status: NOT_YET_RECRUITING
Conditions: Rectal Cancer|Pancreatic Cancer
Interventions: DRUG: [111In]In-DOTA-ANTI-CEA antibody injection|RADIATION: SPECT/CT scan|PROCEDURE: Resection surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prevalence of Helicobacter Pylori Infection and Gastric Cancer in the West Indies
Status: NOT_YET_RECRUITING
Conditions: Stomach Neoplasms|Gastric Neoplasms|Helicobacter Pylori
Interventions: BIOLOGICAL: Helicobacter Pylori detection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Exercise on Thyroid Stimulating Hormone Among Class-I Obese Patients With Diabetes Mellitus and Lipid Disorders
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of the Transient Receptor Potential Vanilloid 4 (TRPV4) Channel Blocker, GSK2798745, on Pulmonary Gas Transfer and Respiration in Patients With Congestive Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: GSK2798745|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Decidual Stromal Cells as Treatment for Acute Graft Versus Host Disease, a Phase 1-2 Study
Status: UNKNOWN
Conditions: Graft vs Host Disease
Interventions: BIOLOGICAL: Decidual Stromal Cells thawed in plasma|BIOLOGICAL: Decidual Stromal Cells thawed in human albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Cardiovascular Side Effects of Teysuno Versus Capecitabine
Status: COMPLETED
Conditions: Gastrointestinal Cancer|Cancer of Unknown Primary Site|Pancreatic Cancer|Bile Duct Neoplasms
Interventions: DRUG: Teysuno|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Adagloxad Simolenin (OBI-822)/OBI-821 in the Adjuvant Treatment of Patients With Globo H Positive TNBC
Status: RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: BIOLOGICAL: adagloxad simolenin combined with OBI-821|DEVICE: Globo H IHC Assay|OTHER: Standard of care treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Psychological and Pharmacological Treatments for Pain Due to Temporomandibular Joint Disorder (TMD)
Status: COMPLETED
Conditions: Temporomandibular Joint Disorders
Interventions: DRUG: Nortriptyline Oral Capsule|DRUG: Benztropine Oral Product|BEHAVIORAL: CBT|BEHAVIORAL: Disease MGT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Efficacy of the Subunit Recombinant Tuberculosis Vaccine GamTBvac
Status: RECRUITING
Conditions: Tuberculosis
Interventions: BIOLOGICAL: GamTBvac|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Drug-Drug Interaction Study of MLC1501 Using Cocktail of Drugs Acting as Sensitive Clinical Probes/Substrates of Cytochrome P450 Isoenzymes and Transporters in Healthy Subjects
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: MLC1501|DRUG: CYP Cocktail|DRUG: Transporter Cocktail
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of RM-493 on Energy Expenditure in Obese Individuals
Status: COMPLETED
Conditions: Obesity|Morbid Obesity
Interventions: DRUG: Placebo|DRUG: RM-493
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Serratus Anterior Plane Block in ED Patients With Rib Fractures
Status: NOT_YET_RECRUITING
Conditions: Rib Fractures|Pain Acute|Regional Anesthesia|Opioid Use
Interventions: PROCEDURE: Serratus Anterior Plane Block|DRUG: Ropivacaine injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Strengthening Community Mental Health
Status: RECRUITING
Conditions: Mental Health|Emotional Wellbeing|Anxiety|Depression|Stress|Coping|Perceived Stress|Perceived Social Support
Interventions: BEHAVIORAL: COPE: Communities Organizing for Power through Empathy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of OTO-104 in Subjects With Unilateral Meniere's Disease
Status: COMPLETED
Conditions: Meniere's Disease
Interventions: DRUG: OTO-104|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Survival of Recombinant Human Neuregulin-1β in Chronic Heart Failure (CHF) Patients
Status: TERMINATED
Conditions: Chronic Heart Failure
Interventions: DRUG: rhNRG-1|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: S0333 Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: filgrastim|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: daunorubicin|DRUG: dexamethasone|DRUG: doxorubicin|DRUG: leucovorin|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: mitoxantrone|DRUG: Asparaginase|DRUG: prednisone|DRUG: thioguanine|DRUG: vincristine|RADIATION: radiation therapy|DRUG: allopurinol|DRUG: bactrim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Educating Missouri Patients About Preemptive Living Donor Transplantation
Status: COMPLETED
Conditions: Chronic Kidney Disease|End Stage Renal Disease
Interventions: BEHAVIORAL: Transplant education with video|BEHAVIORAL: Transplant education with speakers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial of CHOP-R Therapy, With or Without Acalabrutinib, in Patients With Newly Diagnosed Richter's Syndrome
Status: RECRUITING
Conditions: Richter Syndrome
Interventions: DRUG: Acalabrutinib|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisolone|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Characterize the Disease Behavior of Idiopathic Pulmonary Fibrosis (IPF) and Interstitial Lung Disease (ILD) During the Peri-Diagnostic Period
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis|Interstitial Lung Disease
Interventions: OTHER: Spirometry|OTHER: Accelerometry|OTHER: 6MWT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase I Study of Ad5-hGCC (Human Guanylyl Cyclase C)-PADRE in Stage I/II Colon Cancer
Status: COMPLETED
Conditions: Colon Cancer
Interventions: BIOLOGICAL: Ad5-hGCC-PADRE vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase III Randomized Study of Amonafide (AS1413) and Cytarabine Versus Daunorubicin and Cytarabine in Patients With Secondary Acute Myeloid Leukemia (AML)- the ACCEDE Study
Status: UNKNOWN
Conditions: Secondary Acute Myeloid Leukemia (Secondary AML, sAML)
Interventions: DRUG: Daunorubicin and Cytarabine|DRUG: Amonafide and Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impaired HDL and Coronary Artery Disease in Anabolic Androgenic Steroid Users
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: Coronary Computed Tomography Angiography|DIAGNOSTIC_TEST: Macrophage cholesterol efflux mediated by HDL
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Anlotinib in Patients With Differentiated Thyroid Cancer(ALTER01032)
Status: UNKNOWN
Conditions: Differentiated Thyroid Cancer
Interventions: DRUG: Anlotinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study Utilizing Immune Recall to Increase Response to Checkpoint Therapy
Status: RECRUITING
Conditions: Melanoma
Interventions: BIOLOGICAL: Tetanus Diptheria Vaccine|BIOLOGICAL: Polio Boost Immunization
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: Sacituzumab tirumotecan|BIOLOGICAL: Pembrolizumab|DRUG: Cisplatin|DRUG: Pemetrexed|DRUG: Gemcitabine|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of 68Gallium-DOTATATE PET/CT for Detecting Neuroendocrine Tumors
Status: COMPLETED
Conditions: Neuroendocrine Tumors|Von Hippel-Lindau Syndrome|Hippel-Lindau Disease
Interventions: DRUG: 68Gallium DOTATATE|PROCEDURE: Radio-guided surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Transcutaneous Electrical Auricular Stimulation of the Vagus Nerve in Kidney Transplant Recipients
Status: TERMINATED
Conditions: Vagus Nerve Stimulation
Interventions: DEVICE: Transcutaneous electrical auricular vagus nerve stimulation (VNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cytidine and Omega-3 Fatty Acids in Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DIETARY_SUPPLEMENT: cytidine|DIETARY_SUPPLEMENT: omega-3 fatty acids|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Versus Endoscopic Ultrasound-guided Liver Biopsy (PEREUS)
Status: COMPLETED
Conditions: Liver Diseases
Interventions: PROCEDURE: PERCUTANEOUS LIVER BIOPSY (PLB)|PROCEDURE: ENDOSCOPIC ULTRASOUND GUIDED LIVER BIOPSY (EUS-LB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Evaluating the Safety and Efficacy of ATG-008 for Advanced Solid Tumors (BUNCH)
Status: TERMINATED
Conditions: Advanced Solid Tumors
Interventions: DRUG: ATG-008 30 mg, orally, QD, each 4 week (28-day) a cycle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characteristics of Lower Respiratory Tract Escherichia Coli Isolates in Mechanically Ventilated Intensive Care Patients
Status: COMPLETED
Conditions: Nosocomial Pneumonia|Ventilator Associated Pneumonia|Escherichia Coli Infections|Escherichia Coli Pneumonia|Escherichia Coli; Diarrhea, Enteroaggregative|Mechanical Ventilation Complication
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Glanatec(R) for Descemet Stripping in Fuch's Endothelial Dystrophy
Status: RECRUITING
Conditions: Fuchs' Endothelial Dystrophy
Interventions: DRUG: Ripasudil hydrochloride hydrate 0.4% ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 16 Week Study to Evaluate the Effect on Insulin Sensitivity of Valsartan (320 mg) and Hydrochlorothiazide (25 mg) Combined and Alone, in Patients With Metabolic Syndrome
Status: COMPLETED
Conditions: METABOLIC SYNDROME|HYPERTENSION|PRE-HYPERTENSION
Interventions: DRUG: valsartan plus hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Freestyle Prosthesis for Aortic Root-replacement With and Without Hemiarch Replacement
Status: COMPLETED
Conditions: Aortic Aneurysm|Aortic Dissection|Endocarditis|Root Abscess|Valve Heart Disease
Interventions: PROCEDURE: Aortic root replacement with Freestyle biological prosthesis with and without hemiarch replacement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Impact of Protocolized Management, Intensive Rehabilitation Versus Long-term Classic Rehabilitation of Dyslexic Children.
Status: UNKNOWN
Conditions: Dyslexia|Speech Therapy|Children, Only
Interventions: OTHER: Speech Therapy INTENS-DYS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Entacapone,Levodopa and Carbidopa Tablets in Healthy Chinese Subjects
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DRUG: Test (T) Entacapone,Levodopa and Carbidopa Tablets (II)|DRUG: Reference (R) Entacapone,Levodopa and Carbidopa Tablets (II)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Nivolumab and Relatlimab in Combination With Bevacizumab in Advanced Liver Cancer
Status: RECRUITING
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Relatlimab|DRUG: Nivolumab|DRUG: Bevacizumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Persistence of Immunity of PCV13 in Healthy Population Aged 2 Months，7 Months-5 Years
Status: COMPLETED
Conditions: Pneumonia
Interventions: BIOLOGICAL: PCV13|BIOLOGICAL: PCV13|BIOLOGICAL: PCV13|BIOLOGICAL: PCV13
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acalabrutinib and Venetoclax With or Without Early Obinutuzumab for the Treatment of High Risk, Recurrent, or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: RECRUITING
Conditions: Recurrent Chronic Lymphocytic Leukemia|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Small Lymphocytic Lymphoma
Interventions: DRUG: Acalabrutinib|BIOLOGICAL: Obinutuzumab|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Primaquine for Radical Cure of Uncomplicated Plasmodium Vivax Malaria in Children
Status: RECRUITING
Conditions: Malaria, Vivax
Interventions: DRUG: Primaquine|DRUG: Primaquine|DRUG: Primaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest in the Medium Term of an Infrared Reflexotherapy on Overweight or Class I Obese People
Status: TERMINATED
Conditions: Assess the Effect of an IR Reflexotherapy on Overweight and Class I Obese People
Interventions: DEVICE: IR Reflexotherapy|BEHAVIORAL: Dietary care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Passive Ultrasonic Irrigation Versus Needle Irrigation on Postoperative Pain and Periapical Healing
Status: UNKNOWN
Conditions: Apical Periodontitis
Interventions: DEVICE: Passive ultrasonic irrigation|DEVICE: Endodontic needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Observational Study to Monitor Safety and Effectiveness of Obinutuzumab in Follicular Lymphoma or Previously Untreated Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Follicular Lymphoma
Interventions: BIOLOGICAL: obinutuzumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Daratumumab in VHR T-ALL Treated According to the ALL National Treatment Program
Status: NOT_YET_RECRUITING
Conditions: T-Lymphocytic Leukemia, Acute
Interventions: DRUG: Daratumumab plus chemotherapy according to the national treatment program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Ixazomib, Dexamethasone and Rituximab in Patients With Untreated Waldenstrom's Macroglobulinemia
Status: COMPLETED
Conditions: Waldenstrom's Macroglobulinemia
Interventions: DRUG: Ixazomib|DRUG: Dexamethasone|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TTHX1114(NM141) in Combination With DWEK/DSO
Status: COMPLETED
Conditions: Fuchs' Endothelial Dystrophy|Fuchs Dystrophy|Fuchs
Interventions: DRUG: TTHX1114(NM141)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Pre-operative Chemoradiotherapy Followed by Surgical Resection in Pancoast Tumors (JCOG 9806)
Status: COMPLETED
Conditions: Pulmonary Neoplasm
Interventions: DRUG: mitomycin C, vindesine, cisplatin and radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and PK of Subcutaneous D-4517.2 in Subjects With Wet AMD or DME
Status: ACTIVE_NOT_RECRUITING
Conditions: Neovascular Age-related Macular Degeneration|Diabetic Macular Edema
Interventions: DRUG: D-4517.2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sunitinib in Treating Patients With Relapsed Multiple Myeloma
Status: COMPLETED
Conditions: Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma
Interventions: DRUG: sunitinib malate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of IV Human Plasma-derived C1 Esterase Inhibitor Concentrate in Patients With Congenital C1-INH Deficiency for Treatment and Pre-procedure Preventing of Acute Hereditary Angioedema Attacks
Status: RECRUITING
Conditions: Acute Hereditary Angio Edema
Interventions: DRUG: OCTA-C1-INH|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose-escalation Study of ARX788, IV Administered in Subjects With Advanced Cancers With HER2 Expression
Status: TERMINATED
Conditions: Breast Neoplasms|Stomach Neoplasms
Interventions: DRUG: ARX788
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adherence to Health Coaching With Wearable Devices: Enhancing Patient Engagement and Outcomes
Status: NOT_YET_RECRUITING
Conditions: Obstructive Sleep Apnea
Interventions: BEHAVIORAL: STANDARDCARE (STAND) group|OTHER: CONTROL (CON) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Upamostat, a Serine Protease Inhibitor, or Placebo for Treatment of COVID-19 Disease
Status: TERMINATED
Conditions: Covid19
Interventions: DRUG: Part A: Upamostat 200 mg|DRUG: Part A: Upamostat 400 mg|DRUG: Part A and B: Placebo|DRUG: Part B: Upamostat 200 or 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fentanyl Versus Midazolam as an Adjunct to Intrathecal Bupivacaine In Children
Status: COMPLETED
Conditions: Postoperative Analgesia
Interventions: DRUG: Fentanyl|DRUG: Midazolam|DRUG: Bupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Effect of Crustacean's Gastrolith Nutraceutical on Mineralization Rate During Distraction Osteogenesis
Status: UNKNOWN
Conditions: Skeletal Deformities|Leg Length Discrepancy
Interventions: DIETARY_SUPPLEMENT: gastrolith calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: S0927:Omega3-Fatty Acid Supp in Treating Muscle&Bone Pain&Stiffness in Pts W/Stg I,II,III Brst Canc Rec'v Hormone Thpy
Status: COMPLETED
Conditions: Arthralgia|Breast Cancer|Pain
Interventions: DIETARY_SUPPLEMENT: omega-3 fatty acid|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Open Label Trial of Rivastigmine Patch in Subjects With Mild to Moderate Stage AD Having Coexisting svCVD
Status: COMPLETED
Conditions: Alzheimer Disease|CVA (Cerebrovascular Accident)
Interventions: DRUG: Rivastigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Double Blind Study Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy
Status: UNKNOWN
Conditions: Upper Gastrointestinal Bleeding
Interventions: DRUG: Esomeprazole|DRUG: esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NFL LONG Prospective Study
Status: ENROLLING_BY_INVITATION
Conditions: Concussion, Brain
Interventions: DRUG: [11C] PiB|DRUG: [18F] PBR111|DRUG: [18F] Flortaucipir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: DARE: Diabetes in cArdiac REhabilitation
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Coronary Artery Disease
Interventions: OTHER: Conventional antidiabetic treatment|OTHER: Intensive insulin treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Cethrin® in Adult Subjects With Acute Cervical Spinal Cord Injury
Status: WITHDRAWN
Conditions: Acute Cervical Spinal Cord Injury
Interventions: DRUG: Cethrin® (BA-210)|PROCEDURE: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-systemic Rehabilitative Interventions in Long COVID-19 Patients in Two Different Settings: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Long COVID
Interventions: BEHAVIORAL: Multi-systemic Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Test Rizatriptan in the Early Treatment of Acute Migraine (0462-081)
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Comparator: rizatriptan benzoate|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of MM-141 Plus Nab-paclitaxel and Gemcitabine in Front-line Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: MM-141|DRUG: Placebo|DRUG: Gemcitabine|DRUG: Nab-Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics Study of GSK1265744 in Subjects With Severe Renal Impairment
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus|HIV Infections
Interventions: DRUG: GSK1265744 30 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prospective Neuroimaging Investigation of Idiopathic REM Sleep Behavior Disorder
Status: COMPLETED
Conditions: Parkinson Disease|REM Sleep Behavior Disorder
Interventions: OTHER: testing, evaluation, sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Supersaturated Calcium Phosphate Oral Rinse (Caphosol®) For the Prevention of Oral Mucositis in Children Undergoing Chemotherapeutic Treatments
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Caphosol|DRUG: 0,9% NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Identify Biomarkers of Tobacco Exposure and Nicotine Uptake From JUUL 5% in Adult Smokers
Status: COMPLETED
Conditions: Nicotine Dependence, Other Tobacco Product|Tobacco Use|Smoking, Tobacco
Interventions: OTHER: Treatment with JUUL 5%, Virginia Tobacco|OTHER: Treatment with JUUL 5%, Cool Mint, ENDS|OTHER: Treatment with JUUL 5%, Mango, ENDS|OTHER: JUUL 5%, Creme Bruele, ENDS|OTHER: Combustible cigarette|OTHER: Smoking Cessation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Irregular Meal Pattern Providing Hypo-energetic Diet on Energy Expenditure and Metabolism
Status: COMPLETED
Conditions: Metabolic Disturbance|Obesity
Interventions: OTHER: Regular meal pattern|OTHER: Irregular meal pattern
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Neuropharmacokinetics of Eribulin Mesylate in Treating Patients With Primary or Metastatic Brain Tumors
Status: COMPLETED
Conditions: Metastatic Malignant Neoplasm in the Adult Brain|Primary Brain Tumor
Interventions: PROCEDURE: Therapeutic Conventional Surgery|PROCEDURE: Biopsy|DRUG: Eribulin Mesylate|PROCEDURE: Microdialysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Acute Sinusitis With High-Dose vs. Standard-Dose Amoxicillin/Clavulanate
Status: TERMINATED
Conditions: Sinusitis, Acute
Interventions: DRUG: Amoxicillin 875 mg|DIETARY_SUPPLEMENT: Placebo (lactase)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proteomic Profiling in Predicting Response in Patients Receiving Erlotinib for Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: bevacizumab|DRUG: carboplatin|DRUG: erlotinib hydrochloride|DRUG: paclitaxel|GENETIC: gene expression analysis|GENETIC: protein expression analysis|GENETIC: proteomic profiling|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Compare and Evaluate the Safety and Pharmacokinetics of CKD-378
Status: COMPLETED
Conditions: Type II Diabetes
Interventions: DRUG: CKD-378, QD, PO Drug: D745, D150, QD, PO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tension Band Wiring Versus Cannulated Screws in Fixation of Medial Malleolus in Ankle Fracture
Status: COMPLETED
Conditions: Medial Malleolus Fracture
Interventions: PROCEDURE: Tension band wires|PROCEDURE: Cannulated screws
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Lorlatinib in Combination With Ramucirumab in People With Lung Cancer
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer|Metastatic|Recurrent
Interventions: DRUG: Lorlatinib|DRUG: Ramucirumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arthroscopic Assisted Balloon Tibioplasty for the Treatment of Schatzker II-IV Tibial Plateau Fractures
Status: UNKNOWN
Conditions: Arthroscopy|Tibial Fractures|Orthopedic|Fracture Fixation
Interventions: PROCEDURE: Arthroscopic Assisted Balloon Tibioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Daily Hand-Held Vibration Therapy
Status: RECRUITING
Conditions: Neuropathy|Cancer|Chemotherapeutic Drug - Induced Nephropathy|Chemotherapeutic Toxicity
Interventions: DEVICE: Vibration therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trans-pulmonary Pressure in ARDS
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome
Interventions: DEVICE: level of positive end expiratory pressure (Prone Proseva)|DEVICE: level of positive end expiratory pressure (Prone Talmor)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: High Flow Nasal Oxygen Cannula in Transcatheter Aortic Valve Replacement: Complications and Biomarkers
Status: COMPLETED
Conditions: Aortic Stenosis|Sedation Complication
Interventions: DEVICE: High flow nasal oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Alteplase When Administered in Chinese Patients With Acute Ischemic Hemispheric Stroke Where Thrombolysis is Initiated Between 3 and 4.5 Hours After Stroke Onset
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: alteplase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Different Methods for Reducing Pain After Lung Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Postoperative Analgesia
Interventions: PROCEDURE: Rhomboid intercostal block|PROCEDURE: Rhomboid intercostal and subserratus plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: External Validation of the Apfel Risk Score and Koivuranta Score to Predict Postoperative Nausea and Vomiting in Patients With Liver Cancer
Status: UNKNOWN
Conditions: Postoperative Nausea and Vomiting|Hepatobiliary Surgery|Prediction Model
Interventions: OTHER: no intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Problem-solving Based Bibliotherapy Program for Family Caregivers in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia Spectrum Disorders|Family Caregivers
Interventions: BEHAVIORAL: Problem-solving Based Bibliotherapy Program|BEHAVIORAL: Behavioral Management and Education Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Lidocaine Sprayed on Hemodynamics During Endotracheal Intubation
Status: UNKNOWN
Conditions: Neurosurgical Patients
Interventions: DRUG: group C|DRUG: group L|DRUG: group V|DRUG: group LV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vagus Nerve Stimulation ARDS Prevention Trial for COVID-19 Hospitalized Patients
Status: COMPLETED
Conditions: Severe Acute Respiratory Syndrome Coronavirus 2
Interventions: DEVICE: Transcutaneous Auricular Vagus Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Antidepressant Treatment by Genotype-dependent Adjustment of Medication According to the ABCB1 Gene
Status: UNKNOWN
Conditions: Major Depression
Interventions: DRUG: Paroxetine|DRUG: Sertraline|DRUG: Citalopram|DRUG: Venlafaxine|DRUG: Amitriptyline|DRUG: Escitalopram|DRUG: Amitriptylinoxide|DRUG: Nortriptyline|DRUG: Trimipramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Efficacy of MYCOBIOTIC® in Children and Adults With Abdominal Symptoms.
Status: COMPLETED
Conditions: Abdominal Symptoms|Stool Culture Positive for Candida Species
Interventions: DIETARY_SUPPLEMENT: Mycobiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Measurement of the Efficacy of MORPHINE in the Early Management of Dyspnea in COVID-19 Positive Patients
Status: UNKNOWN
Conditions: Patients Hospitalized in the Hospices Civils of Lyon|COVID-19 Disease|Moderate to Severe Dyspnea|Without Resuscitation Objective Management
Interventions: OTHER: No intervention / Compare the difference in respiratory rate between H0 and H12 of the initiation of morphine between the control and interventional groups
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Phosphodiesterase 3 Inhibitor Cilostazol as an Adjunct to Conventional Therapy in Patients With Osteoarthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis
Interventions: DRUG: Cilostazol 50 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Staccato Loxapine Pulmonary Safety in Patients With COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Inhaled Loxapine|DRUG: Inhaled Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of an Ultrasound Renal Denervation System in Patients With Heart Failure
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Heart Failure
Interventions: DEVICE: PRDS-001 Renal Denervation Ultrasound System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Apnea and Oxidative Stress and Nitric Oxide
Status: COMPLETED
Conditions: Sleep Apnea Syndromes
Interventions: DEVICE: nasal continuous positive airway pressure (CPAP) therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: TAS-102 (Lonsurf) in Metastatic or Locally Advanced Unresectable Pancreatic Adenocarcinoma Post First Line Chemotherapy (UF-STO-PANC-003)
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: TAS-102
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Efficacy And Safety of Valdecoxib For Treatment Of Post-Surgical Pain From Bunionectomy Surgery
Status: COMPLETED
Conditions: Pain|Hallux Valgus
Interventions: DRUG: valdecoxib|DRUG: valdecoxib|DRUG: valdecoxib/placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Liraglutide Plus Megestrol Acetate in Endometrial Atypical Hyperplasia
Status: WITHDRAWN
Conditions: Atypical Endometrial Hyperplasia|Obese|Fertility Issues
Interventions: DRUG: Liraglutide Injection|DRUG: Megestrol Acetate 160 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study for Determination of Feasibility and Toxicity of Pre-Treatment With HPPH (2-1[1-Hexyloxyethyl]-2 Devinyl Pyropheophorbide-a) Photodynamic Therapy Prior to Chemoradiation in Non-Operable Patients With Obstructive Esophageal Cancer
Status: WITHDRAWN
Conditions: Esophageal Neoplasm
Interventions: DRUG: HPPH 2-1[1-hexyloxyethyl]-2-devinyl Pyropheophorbide-a)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Biopsy of the Pleura as a Supplement to Extraction of Fluid in Patients With One-sided Fluid in the Pleura
Status: TERMINATED
Conditions: Malignant Pleural Effusion|Exudative Pleural Effusion
Interventions: PROCEDURE: ultrasound-guided pleural biopsy|PROCEDURE: Thoracentesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Axicabtagene Ciloleucel:Neurocognitive and Patient-Reported Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Diffuse Large B Cell Lymphoma|Transformed Lymphoma
Interventions: OTHER: Handgrip strength test|BEHAVIORAL: Neuropsychological Assessment - Wechsler Test of Adult Reading (WTAR)|BEHAVIORAL: Neuropsychological Assessment - Repeatable Battery for the Assessment of Status (RBANS)|BEHAVIORAL: Neuropsychological Assessment - Color Trails|BEHAVIORAL: Neuropsychological Assessment -Stroop Color and Word Test|BEHAVIORAL: Patient Reported Outcomes Measurement Information System-29 (PROMIS-29) Questionnaire|BEHAVIORAL: European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire|BEHAVIORAL: Quality of Life (EQ-5D-5L) Questionnaire|BEHAVIORAL: PROMIS Cognitive Function 4a Questionnaire|BEHAVIORAL: Comprehensive Score for Financial Toxicity (COST) measure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Self-acupressure on Middle Ear Barotrauma Associated With Hyperbaric Oxygen Therapy
Status: UNKNOWN
Conditions: Hyperbaric Oxygen Therapy|Middle Ear Barotrauma
Interventions: PROCEDURE: Self-acupressure therapy|PROCEDURE: Combined Valsalva and Toynbee maneuvers
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: MedActive: A Smartphone Intervention to Improve Adherence to Antipsychotic Medications
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: MedActive|DEVICE: Smartphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Avecure Flexible Microwave Ablation Probe For Lung Nodules
Status: RECRUITING
Conditions: Stage I - II Primary Lung Cancer|Stage I Lung Cancer|Stage II Lung Cancer|Lung Cancer Stage I|Lung Cancer Stage II|Lung Cancer
Interventions: DEVICE: AveCure 16 Gauge Flexible Microwave Ablation Probe
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise-based Cardiac Rehabilitation Program on Hospitalized Heart Failure Patients Submitted to Cardiac Transplantation
Status: UNKNOWN
Conditions: Heart Failure|Transplant; Failure, Heart|Physical Activity
Interventions: OTHER: Conventional exercise protocol|OTHER: Cycle ergometer exercise protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparitive Study Between Uvb Alone and Uvb With Topical Tacrolimus 0.03% for the Treatment of Vitiligo
Status: COMPLETED
Conditions: Vitiligo
Interventions: DRUG: 0.03% tacrolimus twice daily was applied on group A patients with uvb phototherapy thrice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conjugated Linoleic Acid on Body Weight and Body Fat Mass for 12 Weeks
Status: UNKNOWN
Conditions: Overweight and Obesity|Body Weight
Interventions: DIETARY_SUPPLEMENT: CLA-fortified milk powder|OTHER: Placebo|OTHER: Nutrition Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: OrthoPulse™ and Its Effect on the Rate of Orthodontic Tooth Alignment: A Pilot Feasibility Study
Status: COMPLETED
Conditions: Malocclusion
Interventions: DEVICE: OrthoPulse™
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of β-hydroxybutyrate Supplementation as Chemoprevention in Familial Adenomatous Polyposis
Status: NOT_YET_RECRUITING
Conditions: FAP|Familial Adenomatous Polyposis
Interventions: DIETARY_SUPPLEMENT: R-1,3-Butanediol (10MG-A)|DIETARY_SUPPLEMENT: R-1,3-Butanediol (20MG-A)|DIETARY_SUPPLEMENT: R-1,3-Butanediol (30MG-A)|DIETARY_SUPPLEMENT: R-1,3-Butanediol (10MG-B)|DIETARY_SUPPLEMENT: R-1,3-Butanediol (20MG-B)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Trastuzumab Deruxtecan in Participants With HER2-mutated Metastatic Non-small Cell Lung Cancer (NSCLC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Trastuzumab deruxtecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Strategic Memory and Reasoning Training for Cognitive Problems
Status: COMPLETED
Conditions: Traumatic Brain Injury|Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: SMART|BEHAVIORAL: Brain Health Workshop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of the FearNot!v.2.0 Software in Reducing Bullying Victimisation Among Primary School Children
Status: COMPLETED
Conditions: Bullying Victimisation
Interventions: BEHAVIORAL: FearNot
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Mycophenolate Mofetil (CellCept) in Management of Patients With Lupus Nephritis.
Status: COMPLETED
Conditions: Lupus Nephritis
Interventions: DRUG: Mycophenolate mofetil (MMF)|DRUG: Cyclophosphamide|DRUG: Azathioprine|DRUG: Placebo to Azathioprine|DRUG: Placebo to Mycophenolate mofetil|DRUG: Corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PATCH 2&3:Prevention & Treatment of COVID-19 (Severe Acute Respiratory Syndrome Coronavirus 2) With Hydroxychloroquine
Status: TERMINATED
Conditions: Coronavirus|Corona Virus Infection
Interventions: DRUG: Group 1 HCQ|DRUG: Group 2 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Fasting-mimicking Diet With Chemo-immunotherapy in Non-small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: OTHER: Fasting-Mimicking Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Hypnosis on Blood Concentrations of Endocannabinoids
Status: COMPLETED
Conditions: Hypnosis|Endocannabinoids|Analgesia
Interventions: BEHAVIORAL: Hypnosis|BEHAVIORAL: Meditation|OTHER: Conditioned pain modulation|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long-term Treatment on BAY77-1931 (Lanthanum Carbonate) to Measure Lanthanum Concentrations in Bone
Status: COMPLETED
Conditions: Hyperphosphatemia|Dialysis
Interventions: DRUG: Lanthanum Carbonate (BAY77-1931)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT