pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Vitrectomy Combined With Intravitreal Dexamethasone Implant for Idiopathic Epiretinal Membrane With Macular Oedema
Status: ENROLLING_BY_INVITATION
Conditions: Epiretinal Membrane
Interventions: PROCEDURE: vitrectomy combined with intravitreal dexamethasone implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Effects of OPC-34712 on QT/QTc in Subjects With Schizophrenia or Schizoaffective Disorder
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: OPC-34712 (4mg)|DRUG: Moxifloxacin|DRUG: OPC-34712 (12mg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Belun Ring Validation Study for Assessment of Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Belun Ring|DIAGNOSTIC_TEST: PSG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Human Laboratory Study of Smokeless Tobacco Products
Status: WITHDRAWN
Conditions: Smokeless Tobacco
Interventions: OTHER: Nicotine Lozenge|OTHER: Stonewall Dissolvable Tobacco Pieces|OTHER: Camel Snus Frost|OTHER: Skoal Wintergreen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis
Status: RECRUITING
Conditions: NASH With Fibrosis|MASH With Fibrosis
Interventions: DRUG: Efruxifermin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies
Status: RECRUITING
Conditions: B-cell Malignancy|Marginal Zone Lymphoma|Follicular Lymphoma|Non-Hodgkin Lymphoma|Waldenström Macroglobulinemia|Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|Mantle Cell Lymphoma|Diffuse Large B Cell Lymphoma
Interventions: DRUG: BGB-16673
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3 Formulations of Hib-MenCY-TT Vaccine & 1 Formulation of Hib-MenC-TT Vaccine Compared to Licensed Meningococcal Serogroup C Conjugate Vaccine, Each Administered at 2,3,4 Mths of Age
Status: COMPLETED
Conditions: Haemophilus Influenzae Type b|Neisseria Meningitidis
Interventions: BIOLOGICAL: Hib-MenCY-TT vaccine|BIOLOGICAL: Hib-MenC-TT vaccine|BIOLOGICAL: Menjugate ®|BIOLOGICAL: Infanrix penta ®|BIOLOGICAL: Infanrix hexa ®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: GnRH Agonist and Progesterone Versus Progesterone Only for Luteal Phase Support in Antagonist Cycles
Status: UNKNOWN
Conditions: Infertility
Interventions: DRUG: leuprolide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Standard of Care Chemotherapy With or Without Stereotactic Body Radiation Therapy for Oligometastatic Pancreatic Cancer
Status: RECRUITING
Conditions: Metastatic Pancreatic Adenocarcinoma|Stage IV Pancreatic Cancer AJCC v8
Interventions: DRUG: Chemotherapy|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Investigating Efficacy of an Occluding Dentifrice for Dentine Hypersensitivity
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: OTHER: 0.454% w/w stannous fluoride (1100ppm fluoride)|OTHER: 0.76% sodium monofluorophosphate (1000ppm fluoride)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of SGN-B6A in Chinese Participants With Advanced Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Carcinoma, Non-Small Cell Lung|Squamous Cell Carcinoma of Head and Neck|Esophageal Squamous Cell Carcinoma|Gastric Adenocarcinoma|Esophageal Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: sigvotatug vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OXiris for Abdominal SEptic Shock (OASES Study)
Status: NOT_YET_RECRUITING
Conditions: Septic Shock|Abdominal Sepsis|Multi Organ Failure|Blood Purification|AKI - Acute Kidney Injury
Interventions: DEVICE: CRRT filter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Block Characteristics of USG Guided Costoclavicular and Infraclavicular Block With the Perfusion Index
Status: COMPLETED
Conditions: Costoclavicular and Infraclavicular Block for Patients Who Have Undergone Hand,Forearm and Arm Surgery
Interventions: DEVICE: Perfusion Index
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Muscle Injury Following Arthroplasty for Hip Fracture (HF)
Status: COMPLETED
Conditions: Hip Fracture
Interventions: DRUG: PLX-PAD|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: the Prevention of Bone Marrow Suppression Caused by Chemotherapy in Advanced NSCLC With Trilaciclib
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Trilaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Epidemiology and Treatment of Small-colony Variant Staphylococcus Aureus in Cystic Fibrosis
Status: WITHDRAWN
Conditions: Cystic Fibrosis|MRSA
Interventions: DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Green Light Therapy As a Non-Pharmacologic Intervention to Decrease Anxiety in Pregnant Women With Opioid Use Disorder
Status: UNKNOWN
Conditions: Anxiety
Interventions: DEVICE: Exposure to white LED light|DEVICE: Exposure to green LED light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prospective Pilot ATOMS vs AUS
Status: RECRUITING
Conditions: Post-Prostatectomy Incontinence|Urinary Stress Incontinence|Urinary Incontinence|Stress Incontinence, Male
Interventions: DEVICE: Adjustable Transobturator Male System|DEVICE: Artificial Urinary Sphincter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: De Por Vida: A Diabetes Risk Reduction Intervention for Hispanic Women
Status: COMPLETED
Conditions: Diabetes|Weight Loss|PreDiabetes|Obesity
Interventions: BEHAVIORAL: Behavioural Lifestyle Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Deworming Against Tuberculosis
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: Albendazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PET/CT Evaluation of Treatment Response in Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: RADIATION: Radiopharmaceutical Administration [18F]-FDG|RADIATION: Radiopharmaceutical: [18F]-FLT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Botulium Toxin Type A In Non Infectious Chronic Rhinosinusitis
Status: COMPLETED
Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: DRUG: BTX A Topical|DRUG: BTX A Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of an Anti-cancer Drug, Berzosertib (M6620, VX-970), to the Usual Treatments (Carboplatin and Gemcitabine) and to Pembrolizumab for Patients With Advanced Squamous Cell Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Non-Small Cell Squamous Carcinoma|Stage IV Lung Cancer AJCC v8
Interventions: DRUG: Berzosertib|PROCEDURE: Biospecimen Collection|DRUG: Carboplatin|PROCEDURE: Computed Tomography|DRUG: Gemcitabine Hydrochloride|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preliminarily Evaluate the Efficacy of Domperidone in Adult Chinese Participants With Functional Dyspepsia
Status: COMPLETED
Conditions: Dyspepsia
Interventions: DRUG: Domperidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Prolonged Nightly Fasting on Immunotherapy Outcomes in HNSCC - Role of Gut Microbiome
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer
Interventions: BEHAVIORAL: Prolonged Nightly Fasting|BEHAVIORAL: Regular Eating pattern
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nivolumab During Active Surveillance After Neoadjuvant Chemoradiation for Esophageal Cancer: SANO-3 Study
Status: RECRUITING
Conditions: Esophageal Cancer
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Colorado-Oregon Altitude Study
Status: COMPLETED
Conditions: Acute Mountain Sickness
Interventions: DRUG: Erythropoietin|DRUG: Iron sucrose (Venofer)|DRUG: Sterile Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sildenafil for Treatment of Choroidal Ischemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Choroidal Ischemia|Vitelliform Macular Dystrophy|Age-related Macular Degeneration|Central Serous Retinopathy|Retinitis Pigmentosa
Interventions: DRUG: Sildenafil|OTHER: Standard of Care Sildenafil|DIAGNOSTIC_TEST: Ocular Coherence Tomography-Angiography (OCT-A)|OTHER: Visual Acuity (VA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SafeFit Trial: Virtual Clinics to Deliver Universal Interventions in People With Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer|COVID
Interventions: OTHER: Exercise|BEHAVIORAL: Psychological and Behaviour Change Support|OTHER: Nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Stimulation Versus Intermittent Compression for Venous Thromboembolism Prophylaxis in Critical Care
Status: RECRUITING
Conditions: Critical Illness|Sepsis|Acute Illness|Venous Thromboembolism
Interventions: DEVICE: Geko device|DEVICE: Flowtron DVT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Microwave Radiometry Thermometry for the Diagnosis of Critical Limb Ischemia in Diabetic Patients
Status: COMPLETED
Conditions: Diabetic Foot|Peripheral Arterial Disease|Ischaemic Neuropathy
Interventions: OTHER: Tissue thermometry using non-invasive microwave radiometry device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: PREMIER: Lifestyle Interventions for Blood Pressure Control
Status: COMPLETED
Conditions: Heart Diseases|Hypertension
Interventions: BEHAVIORAL: diet, sodium-restricted|BEHAVIORAL: diet, fat-restricted|BEHAVIORAL: exercise|BEHAVIORAL: diet, reducing|BEHAVIORAL: alcohol drinking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: A Study of Mevidalen (LY3154207) in Participants With Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: Mevidalen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Telmisartan Alone and in Combination With Amlodipine in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Telmisartan|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zip-Stitch® in Minimally-Invasive Surgery (ZIMS) - Safety & Efficacy in Hysterectomy
Status: RECRUITING
Conditions: Laparoscopic Hysterectomy
Interventions: DEVICE: Zip-stitch(R)|DEVICE: Reference suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of GNKG168 in Patient With Relapsed or Refractory B-Cell Chronic Lymphocytic Leukemia (B-CLL)
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: GNKG168
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transarterial Chemoembolization by Hepasphere Microspheres for the Treatment of Unresectable Colorectal Liver Metastasis
Status: COMPLETED
Conditions: Unresectable Colorectal Liver Metastasis
Interventions: DEVICE: HepaSphere TACE (transarterial chemoembolization)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intensive Blood Pressure Control on Progression of Coronary Atherosclerosis: Randomized Evaluation by Intravascular Ultrasound
Status: TERMINATED
Conditions: Coronary Artery Disease|Hypertension
Interventions: DRUG: control systolic blood pressure less than 120 mmHg|DRUG: control systolic blood pressure less than 140 mmHg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiological vs Right Ventricular Pacing in Patients With Normal Ventricular Function Post-TAVI
Status: COMPLETED
Conditions: Transcatheter Aortic Valve Implantation|Physiological Pacing|Right Ventricular Pacing|AV Block
Interventions: DEVICE: Physiological pacing|DEVICE: Right ventricular pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Incidence of Hypoglycaemia Events in Patients With Stable Insulin-treated Type 2 Diabetes Mellitus Based on Continuous Glucose Monitoring
Status: UNKNOWN
Conditions: Diabetes Mellitus Type 2 With Hypoglycemia
Interventions: DEVICE: periodic use of Continuous Glucose Monitoring (CGM)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Bimekizumab in Patients With Psoriasis Vulgaris and Active Psoriatic Arthritis
Status: WITHDRAWN
Conditions: Psoriasis Vulgaris|Active Psoriatic Arthritis
Interventions: DRUG: Bimekizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Neoadjuvant Therapy in Patients With Resectable HCC Screened by a Multimodal Deep Learning Model.
Status: NOT_YET_RECRUITING
Conditions: HCC
Interventions: DRUG: HAIC + Tirelizumab +lenvatinib +liver resection|PROCEDURE: liver resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Copanlisib in Relapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL)
Status: COMPLETED
Conditions: Diffuse, Large B-Cell, Lymphoma
Interventions: DRUG: Copanlisib (Aliqopa, BAY80-6946)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of High-energy Digestible Food in Women Undergoing Caesarean Section
Status: UNKNOWN
Conditions: Caesarean Section
Interventions: DIETARY_SUPPLEMENT: high-energy digestible food E2|DIETARY_SUPPLEMENT: glucose injection G2|DIETARY_SUPPLEMENT: normal saline N2|DIETARY_SUPPLEMENT: high-energy digestible food E1|DIETARY_SUPPLEMENT: glucose injection G1|DIETARY_SUPPLEMENT: normal saline N1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of LY2963016 Compared to LANTUS® in Adult Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: LY2963016|DRUG: LANTUS®|DRUG: Oral Antihyperglycemic Medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Revumenib in Combination With Chemotherapy in Participants With R/R Acute Leukemia
Status: COMPLETED
Conditions: Relapsed/Refractory Leukemias|Acute Lymphoblastic Leukemia|Acute Lymphocytic Leukemia|Mixed Phenotype Acute Leukemia|Acute Myeloid Leukemia|Acute Undifferentiated Leukemia
Interventions: DRUG: Revumenib|DRUG: Chemotherapy Regimen 1|DRUG: Chemotherapy Regimen 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial Assessing Efficacy and Toxicity of Capecitabine and Oxaliplatin in the Treatment of Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Capecitabine, Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Multicenter Phase 2 Study of the Chemotherapy-Free Combination of the Intravenous Phosphatidylinositol-3-Kinase (PI3K) Inhibitor Copanlisib in Combination With Obinutuzumab in Patients With Previously Untreated Follicular Lymphoma (FL) and a High Tumor Burden
Status: ACTIVE_NOT_RECRUITING
Conditions: Follicular Lymphoma
Interventions: DRUG: Copanlisib|DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heuristic Tool To Improve Symptom Self-Management in Adolescents and Young Adults With Cancer
Status: RECRUITING
Conditions: Symptoms and Signs|Cancer|Childhood Cancer
Interventions: BEHAVIORAL: Computerized Symptom Capture Tool (C-SCAT) Intervention|BEHAVIORAL: Usual Care Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study
Status: RECRUITING
Conditions: Salt-Sensitivity of Blood Pressure
Interventions: DRUG: Furosemide (Diuretic)|OTHER: Hypertonic Saline Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Targeted T Cells After Neoadjuvant Chemotherapy in Treating Women With Stage II or III Breast Cancer Undergoing Surgery
Status: TERMINATED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: HER2Bi-armed activated T cells|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: paclitaxel|OTHER: laboratory biomarker analysis|PROCEDURE: neoadjuvant therapy|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of the Partial Pressure of Carbon Dioxide During Exercise and at Night in Patients With Chronic Obstructive Pulmonary Disease (COPD) IV
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: PROCEDURE: 6-minute walking test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: 64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer
Status: NOT_YET_RECRUITING
Conditions: Metastatic Sarcoma|Esophageal Cancer|Gastric Cancer|Pancreatic Cancer|Colorectal Cancer|Sarcoma
Interventions: COMBINATION_PRODUCT: 64Cu-LNTH-1363S
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Single Arm Study Evaluating the Efficacy, Safety and Tolerability of Ofatumumab in Patients With Relapsing Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: Ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies
Status: COMPLETED
Conditions: Accelerated Phase Chronic Myelogenous Leukemia|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Blastic Phase Chronic Myelogenous Leukemia|Childhood Burkitt Lymphoma|Childhood Chronic Myelogenous Leukemia|Childhood Diffuse Large Cell Lymphoma|Childhood Immunoblastic Large Cell Lymphoma|Childhood Myelodysplastic Syndromes|Childhood Nasal Type Extranodal NK/T-cell Lymphoma|Chronic Phase Chronic Myelogenous Leukemia|Cutaneous B-cell Non-Hodgkin Lymphoma|de Novo Myelodysplastic Syndromes|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Post-transplant Lymphoproliferative Disorder|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Recurrent/Refractory Childhood Hodgkin Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Relapsing Chronic Myelogenous Leukemia|Secondary Myelodysplastic Syndromes|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|T-cell Large Granular Lymphocyte Leukemia|Testicular Lymphoma|Waldenström Macroglobulinemia
Interventions: BIOLOGICAL: therapeutic allogeneic lymphocytes|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patent Ductus Arteriosus (PDA) Screening Trial
Status: COMPLETED
Conditions: Ductus Arteriosus, Patent
Interventions: OTHER: Nondisclosure of screening echocardiogram results|OTHER: Disclosure of screening echocardiogram results
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effect of Methylprednisolone on Complement Activation in Patients Undergoing Total Knee-arthroplasty
Status: COMPLETED
Conditions: Osteoarthrosis
Interventions: DRUG: Methylprednisolone|DRUG: Isotonic Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Vitamin B12a Vasoplegic Syndrome
Status: TERMINATED
Conditions: Vasoplegic Syndrome
Interventions: DRUG: Hydroxocobalamin|PROCEDURE: Cardiopulmonary Bypass|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: High Dose IV Lidocaine vs Hydromorphone for Abdominal Pain in the Emergency Department
Status: TERMINATED
Conditions: Abdominal Pain|Renal Colic
Interventions: DRUG: Lidocaine Iv|DRUG: HYDROmorphone Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Auditory Slow Wave Enhancement After Concussion
Status: RECRUITING
Conditions: Concussion Post Syndrome
Interventions: DEVICE: Auditory Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Community-Led Action Research in Oncology: Improving Symptom Management
Status: COMPLETED
Conditions: Chemotherapy-induced Neutropenia|Chemotherapy-induced Nausea and Vomiting|Anxiety|Depression|Fatigue|Neoplasms
Interventions: BEHAVIORAL: symptom management program for chemotherapy patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I Study Evaluating the Safety, Tolerability, PK and PD in Healthy Chinese Volunteers
Status: COMPLETED
Conditions: Healthy Chinese Volunteers
Interventions: DRUG: HBM9161(HL161BKN)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nimotuzumab Combined With Trifluridine/Tipiracil in the Treatment of Refractory Metastatic Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Refractory Metastatic Colorectal Cancer
Interventions: DRUG: Nimotuzumab injection|DRUG: Placebo|DRUG: Trifluridine/tipiracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implant Supported Single Crowns With Different Retention Modes
Status: RECRUITING
Conditions: Complications: Inflammatory Reactions, Mechanical Complications
Interventions: OTHER: conometric concept Acuris system|OTHER: screw retention|OTHER: cementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Sufentanil, Fentanyl and Remifentanil in Combination With Midazolam During Bronchoscopy Under Conscious Sedation
Status: COMPLETED
Conditions: Sufentanil|Remifentanil|Fentanyl|Bronchoscopy|Narcotrend|Conscious Sedation
Interventions: DRUG: Sufentanil|DRUG: Fentanyl|DRUG: Remifentanil|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of Immunogenicity and Safety of the Diphtheria, Tetanus, Pertussis and Inactivated Poliovirus (DPT-IPV) Vaccine Squarekids Co-administered With GSK Biologicals' Human Rotavirus (HRV) Vaccine Rotarix (GSK444563) in Healthy Infants
Status: COMPLETED
Conditions: Rotavirus
Interventions: BIOLOGICAL: Squarekids|BIOLOGICAL: Rotarix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of the Safety, Tolerability, Pharmacokinetics and Efficacy of Treatment With AP1189 in Patients With iMN and Severe Proteinuria
Status: RECRUITING
Conditions: Nephrotic Syndrome Due to Idiopathic Membranous Nephropathy|Severe Proteinuria Due to Idiopathic Membranous Nephropathy
Interventions: DRUG: 100 mg AP1189|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Dose Study for LCB01-0371
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LCB01-0371 800mg|DRUG: LCB01-0371 1200mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interaction Study Between Henagliflozin Proline and Hydrochlorothiazide
Status: COMPLETED
Conditions: Diabetes in Adults
Interventions: DRUG: Hydrochlorothiazide、Henagliflozin Proline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hips Screws or (Total) Hip Replacement for Undisplaced Femoral Neck Fractures in Elderly Patients (HipSTHeR)
Status: RECRUITING
Conditions: Femoral Neck Fractures|Undisplaced Fracture
Interventions: DEVICE: Arthroplasty|DEVICE: Internal Fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of RP-3500, Camonsertib, in Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: RP-3500 (camonsertib)|DRUG: Talazoparib|DRUG: Gemcitabine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Bronchodilator Response in Patients With Bronchiectasis
Status: RECRUITING
Conditions: Bronchiectasis|Cystic Fibrosis|Primary Ciliary Dyskinesia|Primary Immune Deficiency|Bronchiolitis Obliterans
Interventions: DIAGNOSTIC_TEST: spirometry|DRUG: Salbutamol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Infusing Diversity to Enhance Adapted Treatment (IDEA)
Status: ENROLLING_BY_INVITATION
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Trauma-Focused Cognitive Behavioral Therapy (TF-CBT)|BEHAVIORAL: Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) augmented with Racial Socialization (RS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE
Status: COMPLETED
Conditions: Pulmonary Hypertension|Interstitial Lung Disease|Combined Pulmonary Fibrosis and Emphysema
Interventions: DRUG: Inhaled Treprostinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation Of Safety And Efficacy Of 0.3 Mg/Eye Macugen In Patients With Small Age-Related Macular Degeneration Lesions
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DRUG: pegaptanib sodium (Macugen)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intensity-Modulated Radiation Therapy (IMRT) in the Treatment of Non-Anaplastic Non-Medullary Thyroid Cancer
Status: COMPLETED
Conditions: Thyroid Cancer
Interventions: RADIATION: IMRT|DEVICE: DWI MRI|DRUG: Doxorubicin|OTHER: Modified Barium Swallow Impairment Profile (MBSImP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Care Through Azithromycin Research for Infants in Africa
Status: RECRUITING
Conditions: Child Mortality
Interventions: DRUG: Azithromycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing the Efficacy of Nitazoxanide Versus Rifaximin in Adult Patients With Irritable Bowel Syndrome Without Constipation
Status: RECRUITING
Conditions: Irritable Bowel Syndrome With Diarrhea
Interventions: DRUG: Nitazoxanide 500Mg Oral Tablet|DRUG: Rifaximin 550Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Frailty With Fisetin and Exercise (PROFFi) in Breast Cancer Survivors
Status: RECRUITING
Conditions: Anatomic Stage I Breast Cancer American Joint Committee on Cancer (AJCC) v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Early Stage Breast Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Educational Intervention|OTHER: Exercise Intervention|DRUG: Fisetin|OTHER: Physical Performance Testing|DRUG: Placebo Administration|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Guided Feedback in an Online Game Impacts Decision Making
Status: COMPLETED
Conditions: Depressive Symptoms
Interventions: BEHAVIORAL: Video|BEHAVIORAL: Active game|BEHAVIORAL: Neutral game
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Assessment of Efficacy and Safety of Topical Administration of 1% Glycopyrronium Bromide (GPB) in Patients With Primary Axillary Hyperhidrosis and the Assessment of Long-term Efficacy and Safety of Topical Administration of 1% GPB Cream in Patients With Primary Axillary Hyperhidrosis.
Status: COMPLETED
Conditions: Primary Axillary Hyperhidrosis
Interventions: DRUG: WO3970|DRUG: Placebo (WO3988)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Strict or Liberal Insulin Protocol Following Coronary Artery Bypass Graft (CABG) Surgery
Status: COMPLETED
Conditions: Blood Glucose|Coronary Artery Bypass|Insulin|Coronary Disease
Interventions: OTHER: LIBERAL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate RMC-035 in Subjects Undergoing Cardiac Surgery
Status: COMPLETED
Conditions: Acute Kidney Injury (AKI)
Interventions: DRUG: RMC-035|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose Confirmation Study of Cotara for the Treatment of Glioblastoma Multiforme at First Relapse
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: 131I-chTNT-1/B MAb (Cotara)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CBT Augmentation to Promote Medication Discontinuation in Pediatric OCD
Status: RECRUITING
Conditions: Cognitive Behavioral Therapy|Obsessive-Compulsive Disorder|Obsessive-Compulsive Disorder in Children|Obsessive-Compulsive Disorder in Adolescence
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: QUILT-3.033: Haplo NK With SQ ALT-803 for Adults With Relapsed or Refractory AML
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: ALT-803
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fibrin Glue Versus Tacked Fixation in Groin Hernia Repair (TAPP)
Status: COMPLETED
Conditions: Inguinal Hernia|Femoral Hernia
Interventions: PROCEDURE: Fibrin glue|PROCEDURE: Tacks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Tolvaptan for Patients With Tricuspid Regurgitation and Right Heart Failure After Left Heart Valves Replacement
Status: COMPLETED
Conditions: Tricuspid Regurgitation|Right Heart Failure
Interventions: DRUG: tolvaptan+torasemide|DRUG: placebo+torasemide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Xin'an Medicine in the Treatment of Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: glucosamine sulfate|DRUG: Xinfeng capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation, Safety and Pharmacokinetic Study of AVE8062 in Patients With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: ombrabulin (AVE8062)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Scandinavian Randomized Controlled Trial of Isolated Hepatic Perfusion for Uveal Melanoma Liver Metastases
Status: COMPLETED
Conditions: Melanoma|Uveal Neoplasms
Interventions: PROCEDURE: IHP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diet, Physical Activity and Related Candidate Biomarkers in Relation to Prostate Cancer Risk (BIOCaPPE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Epidemiology|Prostate Cancer
Interventions: OTHER: Lifestyle questionnaires|DIAGNOSTIC_TEST: Prostate Biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Gastric Bypass Surgery on Brain Responses
Status: SUSPENDED
Conditions: Obesity|Hormone Responses|Cognitive Health
Interventions: PROCEDURE: Bariatric surgery|BEHAVIORAL: Brain activity in resting state|BEHAVIORAL: Memory performance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Plant Stanols and Liver Inflammation in Overweight and Obese Children
Status: UNKNOWN
Conditions: Non-Alcoholic Fatty Liver Disease|Non-alcoholic Steatohepatitis|NAFLD|NASH|NASH - Nonalcoholic Steatohepatitis|Childhood Obesity|Childhood Overweight|Pediatric Obesity
Interventions: DIETARY_SUPPLEMENT: Plant stanols (3g/day)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Canakinumab With Chemotherapy, Radiation Therapy, and Durvalumab in People With Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Canakinumab|DRUG: Durvalumab|RADIATION: Radiation therapy|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Cervical Cerclage or Vaginal Progesterone on Vaginal Microbiome Distribution
Status: UNKNOWN
Conditions: Preterm Labor
Interventions: DIAGNOSTIC_TEST: vaginal swab -microbiome test and blood test for cytokines
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Low-Level Laser Therapy Efficacy in Pain Management of Grade 2 Oral Mucositis Induced by Radiotherapy or Chemoradiotherapy: a Study in Patients With Upper Aerodigestive Tract Cancer
Status: WITHDRAWN
Conditions: Upper Aerodigestive Tract Neoplasms
Interventions: DEVICE: Basic Oral Care + active LLLT|OTHER: Basic oral Care + inactive LLLT|OTHER: Basic Oral Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase IV Clinical Trial to Evaluate the Efficacy and Safety of PlbCR and Aceclofenac in the Treatment of Patients With Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis of Knee
Interventions: DRUG: Pelubiprofen CR 45mg tab.|DRUG: Aceclofenac 100mg tab.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Motive-Oriented Therapeutic Relationship in the Early-Phase Treatment of Borderline Personality Disorder
Status: COMPLETED
Conditions: Borderline Personality Disorder
Interventions: BEHAVIORAL: Psychiatric Management|BEHAVIORAL: Motive-oriented therapeutic relationship/Plan Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Study of Quadruple Therapy Intranasal Insulin, Zinc, Gabapentin, Ice Cube Stimulation for Post COVID-19 Smell and Taste Dysfunctions
Status: UNKNOWN
Conditions: Smell Dysfunction|Taste Disorders|Taste Disorder, Secondary, Sweet|Taste Disorder, Secondary, Bitter|Smell Disorder
Interventions: DRUG: Insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KanSurvive: Testing a Model for Improving Cancer Survivorship Care in Rural Practice
Status: COMPLETED
Conditions: Breast Cancer|Colorectal Cancer|Lung Cancer|Prostate Cancer
Interventions: BEHAVIORAL: Telementoring with Practice Facilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: CP-868,596 And CP-868,596 Plus AG-013736 In Combination With Docetaxel In Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: CP-868,596|DRUG: Docetaxel|DRUG: CP-868,596|DRUG: Docetaxel|DRUG: CP-868,596|DRUG: Docetaxel|DRUG: CP-868,596|DRUG: AG-013736|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential Administration of FE75C and Docetaxel Versus Docetaxel/Cyclophosphamide in HER-2 Negative, Node Positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Docetaxel|DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: 5-fluoruracil|DRUG: Granulocyte-colony stimulating growth factor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gabapentin Reduces Opioid Use Postoperatively ("GROUP Study")
Status: UNKNOWN
Conditions: Pelvic Organ Prolapse
Interventions: DRUG: Gabapentin|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Bioavailability Of Sulforaphane From Broccoli Soups Study (BOBS)
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Standard broccoli and stilton soup|DIETARY_SUPPLEMENT: Beneforte broccoli and stilton soup|DIETARY_SUPPLEMENT: Beneforte Extra broccoli and stilton soup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hydroxyurea to Prevent Brain Injury in Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease|Stroke
Interventions: DRUG: Hydroxyurea|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Single Dose, Three-arm Study to Compare the Pharmacokinetic Similarity of MAB-22 Versus Prolia®
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: MAB-22|DRUG: EU-Prolia®|DRUG: US-Prolia®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Minimal Invasive Surgery in Total Hip Arthroplasty Patients; Short- and Long Term Results
Status: COMPLETED
Conditions: Hip Osteoarthritis
Interventions: PROCEDURE: Total hip arthroplasty direct lateral approach|PROCEDURE: Total hip arthroplasty posterior approach|PROCEDURE: Total hip arthroplasty, anterior approach
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Destruction of Residual Endo-biliary Dysplastic Buds After Endoscopic Ampullectomy
Status: COMPLETED
Conditions: Adenoma, Bile Duct
Interventions: DEVICE: Habib™ EndoHBP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT