pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Influence of Breastfeeding on Cortical Activity During Procedures
Status: COMPLETED
Conditions: Pain|Neonatal
Interventions: OTHER: Breastfeeding|DRUG: 24% oral sucrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Imatinib Mesylate in Treating Patients With Extensive-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: imatinib mesylate|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC
Status: UNKNOWN
Conditions: CDA Type I
Interventions: DRUG: omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TRV130 for the Treatment of Pain After Abdominoplasty
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: TRV130|DRUG: Morphine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between aPDT and Systemic Doxycycline on Non-surgical Periodontal Therapy in Type 2 Diabetics
Status: COMPLETED
Conditions: Periodontal Disease|Type 2 Diabetes
Interventions: DRUG: Systemic Doxycycline and Sham aPDT|DRUG: aPDT + Doxycycline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neurostimulation an Adjuvant Postoperative Analgesic in Total Knee Replacement (TKR) Surgeries
Status: UNKNOWN
Conditions: Arthroplasty, Knee Replacement
Interventions: DEVICE: Primary Relief|DEVICE: Inactive Primary Relief
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Glutamine Supplementation in Critically Ill Patients With Severe Sepsis
Status: COMPLETED
Conditions: Severe Sepsis
Interventions: DIETARY_SUPPLEMENT: Glutamine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Pioglitazone Versus Glimepiride in Type 2 Diabetes Inadequately Controlled With Metformin Plus Alogliptin
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Pioglitazone|DRUG: Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BiZact™ on Children and Adolescents Undergoing Tonsillectomy
Status: COMPLETED
Conditions: Tonsillectomy
Interventions: DEVICE: BiZact™: A bipolar instrument for tonsillectomies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beta-cell Response to Incretin Hormones in Cystic Fibrosis
Status: RECRUITING
Conditions: Cystic Fibrosis|Pancreatic Insufficiency
Interventions: DRUG: GLP-1|DRUG: GIP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Invasive Group A Streptococcus (GAS) Infection in Children: Bacterial Virulence Factors and Detection of Host Immunological and/or Genetic Factors of Predisposition to Infections
Status: COMPLETED
Conditions: Invasive GAS Infection
Interventions: GENETIC: DNA samples, GAS strains
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigation of Oscillations Underlying Human Cognitive and Affective Processing Using Intracranial EEG
Status: TERMINATED
Conditions: Working Memory|Emotions
Interventions: BEHAVIORAL: Working Memory Task|BEHAVIORAL: Reward Learning Task|BEHAVIORAL: Facial Emotion Recognition Task
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cardiovascular Impact, Quality e Quantity of Sleep in Bed Partners of Patients With Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea Syndromes
Interventions: DEVICE: Continuous positive airway pressure (CPAP)|DEVICE: Nasal strip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ixazomib (MLN9708) in Combination With Carboplatin in Pretreated Women With Advanced Triple Negative Breast Cancer
Status: TERMINATED
Conditions: Triple-Negative Breast Cancer
Interventions: DRUG: Ixazomib|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: WOMAC Hip Score in Children and Adolescents With Perthes Disease
Status: UNKNOWN
Conditions: Legg-Calvé-Perthes Disease
Interventions: BEHAVIORAL: WOMAC questionnaire at baseline|BEHAVIORAL: ASK-P questionnaire at baseline|BEHAVIORAL: WOMAC questionnaire at 2 weeks
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Sugary Drinks Counter-marketing Messages
Status: COMPLETED
Conditions: Obesity|Weight Prejudice|Weight Gain|Dietary Habits
Interventions: BEHAVIORAL: Exposure to counter-marketing messages|BEHAVIORAL: Exposure to traditional health messages|BEHAVIORAL: Exposure to control (neutral) messages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Valiloxybate (XW10172 MR) Efficacy and Safety Parkinson's Disease Study
Status: UNKNOWN
Conditions: Parkinson Disease|Excessive Daytime Somnolence
Interventions: DRUG: Valiloxybate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Pharmacokinetics, Pharmacodynamics, and Safety of Efgartigimod Administered Intravenously in Children With Generalized Myasthenia Gravis
Status: RECRUITING
Conditions: Generalized Myasthenia Gravis
Interventions: BIOLOGICAL: Efgartigimod IV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Efficacy of OPC-34712 as a Complementary Therapy in the Treatment of Adult Attention Deficit/Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: OPDC-34712|DRUG: Placebo|DRUG: Stimulant Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Open-Label Duloxetine Extension Phase in Patients Who Have Completed Previous Duloxetine Trials
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Duloxetine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Success of Zirconia and Stainless Steel Crowns for Permanent Molars
Status: COMPLETED
Conditions: Caries Active|Dentin, Carious
Interventions: DEVICE: zirconia crowns|DEVICE: stainless steel crowns
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Duration Versus Standard Response-Guided Therapy With Boceprevir Combined With PegIntron and Ribavirin in Previously Untreated Non-Cirrhotic Asian Participants With Chronic HCV Genotype 1 (MK-3034-107)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Boceprevir|BIOLOGICAL: Peg-interferon alfa-2b|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peritoneal Vacuum Therapy to Reduce Inflammatory Response From Abdominal Sepsis/Injury
Status: COMPLETED
Conditions: Abdominal Compartment Syndrome|Intra-abdominal Hypertension
Interventions: DEVICE: KCI AbThera|DEVICE: "Stampede" VAC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Sertraline and Early Alprazolam XR Administration Versus Sertraline Only in Panic Disorder Patients
Status: COMPLETED
Conditions: Panic Disorder
Interventions: DRUG: Sertraline and Alprazolam XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of Autogenous Dentin Graft on Socket Preservation
Status: COMPLETED
Conditions: Bone Regeneration|Bone And Bones|Bone Substitutes
Interventions: BIOLOGICAL: autogenous dentin graft|BIOLOGICAL: platelet rich fibrin (PRF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of RoActemra/Actemra and, if Initially Inadequately Responded to RoActemra/Actemra, Followed by MabThera/Rituxan in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: rituximab [MabThera/Rituxan]|DRUG: tocilizumab [RoActemra/Actemra]|DRUG: tocilizumab [RoActemra/Actemra]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: , "Mucosal Injury During Nasotracheal Intubation for Dental Procedures in Children-does the Tube Design Matter?"
Status: COMPLETED
Conditions: Epistaxis
Interventions: DEVICE: Parker flex-tip nasotracheal tube|DEVICE: Standard nasotracheal tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Immunotherapy of HLA-A2 Positive Stage II-IV Melanoma Patients
Status: TERMINATED
Conditions: Melanoma
Interventions: BIOLOGICAL: 2 vaccine injections in 1 limb|BIOLOGICAL: 2 vaccine injections in distinct limbs|BIOLOGICAL: 2 "vaccine injections" in distinct limbs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of Pharmacokinetics of Different Curcuminoids Preparations: Pilot Study
Status: COMPLETED
Conditions: Plasma Levels of Different Curcuminoids Preparations
Interventions: DIETARY_SUPPLEMENT: Curcumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Ranibizumab as a Rescue Therapy for Diabetic Macular Edema
Status: WITHDRAWN
Conditions: Diabetic Macular Edema
Interventions: DRUG: injection of 0.5 mg of Intravitreal Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single and Multiple Doses of HA115 and Food Effect in Healthy Adult Volunteers
Status: WITHDRAWN
Conditions: Asthma
Interventions: DRUG: HA115|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Facial Hair Reduction Using Intense Pulsed Light (IPL) & Alexandrite Laser
Status: UNKNOWN
Conditions: Hirsutism
Interventions: DEVICE: Intense Pulsed Light (IPL)|DEVICE: Alexandrite Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade Glioma
Status: TERMINATED
Conditions: Brain Tumor|Anaplastic Astrocytoma|Anaplastic Ependymoma|Anaplastic Oligodendroglioma|Brain Stem Glioma|Giant Cell Glioblastoma|Glioblastoma|Gliosarcoma|Mixed Glioma
Interventions: DRUG: ritonavir|DRUG: lopinavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Preoperative Oral Carbohydrates on the Glycemic Variability of Diabetic Patients
Status: COMPLETED
Conditions: Diabetes
Interventions: DIETARY_SUPPLEMENT: carbohydrate group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Microneedling vs. Autologous Concentrated Growth Factor for the Treatment of Female Androgenetic Alopecia
Status: RECRUITING
Conditions: Androgenetic Alopecia
Interventions: PROCEDURE: microneedling|PROCEDURE: Autologous Concentrated Growth Factor|DRUG: 5% minoxidil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Training on Outdoor Fitness Equipment for Health Improvement
Status: COMPLETED
Conditions: Physical Inactivity|Healthy
Interventions: BEHAVIORAL: Training on BIOFIT-Park|BEHAVIORAL: Training on gym park equipament
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Trial of HBM9378 in Healthy Chinese Subjects
Status: RECRUITING
Conditions: Asthma
Interventions: DRUG: HBM9378 (SKB378) Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Radiological Outcomes of Subchondroplasty in the Treatment of Bone Marrow Edema of the Knee
Status: COMPLETED
Conditions: Bone Marrow Edema
Interventions: PROCEDURE: subchondroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lapatinib Ditosylate in Treating Patients With a Rising PSA Indicating Recurrent Prostate Cancer
Status: COMPLETED
Conditions: Recurrent Prostate Cancer|Stage I Prostate Cancer|Stage IIA Prostate Cancer|Stage IIB Prostate Cancer|Stage III Prostate Cancer
Interventions: DRUG: lapatinib ditosylate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Modulation by Parenteral Fish Oil in Patients With Crohn's Disease
Status: COMPLETED
Conditions: Crohn Disease
Interventions: DRUG: Omegaven 10%|DRUG: Intralipid 20%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Jellyfish Stings
Status: COMPLETED
Conditions: Bites and Stings
Interventions: OTHER: Safe Sea ™|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Targeted Cognitive Training in Clinical High Risk (CHR) for Psychosis
Status: COMPLETED
Conditions: Clinical High Risk for Psychosis
Interventions: BEHAVIORAL: Targeted Cognitive Training|BEHAVIORAL: Computer Games
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: How Similar Are Changes to the Surface of the Eye When Two Different Glaucoma Eye Drops Are Used?
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: Xalatan|DRUG: Travatan Z
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Retention of Flowable Resin With Sprg and of a Flowable Resin in First Permanent Molars
Status: UNKNOWN
Conditions: Pit and Fissure Sealant
Interventions: DEVICE: Giomer Beautifil flow plusF03 Shofu-Japan|DEVICE: Tetric N flow ivoclar vivadent-Germany
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Safety, Tolerability, and Efficacy of MDGN-002 in Adults With Moderate to Severe Active Crohn's Disease or Ulcerative Colitis
Status: TERMINATED
Conditions: Crohn Disease|Ulcerative Colitis
Interventions: DRUG: MDGN-002
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erlotinib Hydrochloride in Treating Patients With Stage I-III Colorectal Cancer or Adenoma
Status: COMPLETED
Conditions: Adenomatous Polyp|Recurrent Colon Cancer|Recurrent Rectal Cancer|Stage I Colon Cancer|Stage I Rectal Cancer|Stage IIA Colon Cancer|Stage IIA Rectal Cancer|Stage IIB Colon Cancer|Stage IIB Rectal Cancer|Stage IIC Colon Cancer|Stage IIC Rectal Cancer|Stage IIIA Colon Cancer|Stage IIIA Rectal Cancer|Stage IIIB Colon Cancer|Stage IIIB Rectal Cancer|Stage IIIC Colon Cancer|Stage IIIC Rectal Cancer
Interventions: DRUG: erlotinib hydrochloride|OTHER: placebo|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Air Optix Plus HydraGlyde Multifocal Daily/Extended Wear Contact Lenses
Status: COMPLETED
Conditions: Refractive Errors
Interventions: DEVICE: Lotrafilcon B multifocal soft contact lenses|DEVICE: Comfilcon A multifocal soft contact lenses
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rehabilitative Trial With tDCS in Amyotrophic Lateral Sclerosis
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DEVICE: Anodal bilateral motor cortex and cathodal spinal tDCS|DEVICE: Sham bilateral motor cortex and sham spinal tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Irbesartan/Hydrochlorothiazide (HCTZ) Combination Therapy as First Line Treatment for Severe Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Irbesartan/HCTZ|DRUG: Irbesartan monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Maintenance Treatment of Nimotuzumab for Advanced Esophageal Carcinoma
Status: WITHDRAWN
Conditions: Stage IV Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Nimotuzumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Bictegravir + Emtricitabine/Tenofovir Alafenamide Versus Dolutegravir + Emtricitabine/Tenofovir Alafenamide in HIV-1 Infected, Antiretroviral Treatment-Naive Adults
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: BIC|DRUG: F/TAF|DRUG: DTG|DRUG: BIC Placebo|DRUG: DTG Placebo|DRUG: B/F/TAF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Whether Different Doses of Alteplase Help People With Severe Breathing Problems Because of COVID-19
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome
Interventions: PROCEDURE: Standard of care|DRUG: Alteplase low dose|DRUG: Alteplase high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimization of Pre-operative Oral Analgesics in Patients Undergoing Ambulatory Minimally Invasive Hysterectomy
Status: COMPLETED
Conditions: Hysterectomy|Laparoscopy|Analgesia
Interventions: OTHER: Timing of pre-operative oral non-narcotic analgesics in relation to minimally invasive hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stress, Dietary Lapse and Weight Loss Among Adults With Type 2 Diabetes
Status: COMPLETED
Conditions: Obesity|Type 2 Diabetes
Interventions: BEHAVIORAL: Personalized diet plan and PDA self reporting.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Role of Statin on the Gastric Inflammation in Patients at High Risk of Gastric Cancer
Status: COMPLETED
Conditions: Early Gastric Cancer or Gastric Adenoma
Interventions: DRUG: Arm1: Statin|DRUG: Arm2: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of DE-105 Ophthalmic Solution in Patients With Persistent Corneal Epithelial Defect
Status: COMPLETED
Conditions: Persistent Corneal Epithelial Defect
Interventions: DRUG: DE-105 ophthalmic solution|DRUG: DE-105 ophthalmic solution|DRUG: Placebo ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA) in Major Abdominal Surgeries
Status: COMPLETED
Conditions: Abdominal Surgery
Interventions: PROCEDURE: M-TAPA block|PROCEDURE: SCTAP block|DRUG: Bupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Complications Related to Palatal Graft Harvesting
Status: ENROLLING_BY_INVITATION
Conditions: Cicatrization
Interventions: PROCEDURE: UPV/EHU technique (Aguirre-Zorzano et al 2017)|PROCEDURE: Single incision technique (Huerzeler & Weng 1999)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 6-week Safety & Efficacy Study of Combination Intraocular Pressure-lowering Therapy in Patients With Open-angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma, Open-angle|Ocular Hypertension
Interventions: DRUG: Combination IOP Lowering Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Multicenter, Study of APF530 (Granisetron) SC for Prevention of CINV in Patients Receiving HEC
Status: COMPLETED
Conditions: Chemotherapy-induced Nausea and Vomiting
Interventions: DRUG: APF530|DRUG: Ondansetron|DRUG: Ondansetron placebo|DRUG: APF530 placebo|DRUG: Fosaprepitant|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of a Selective ALDH2 Inhibitor to Treat AUD
Status: WITHDRAWN
Conditions: Alcohol Use Disorder
Interventions: DRUG: ANS-6637 Low Dose|DRUG: ANS-6637 High Dose|DRUG: Matched Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lipopolysaccharide Adsorption (Efferon LPS NEO) in Children With Sepsis
Status: RECRUITING
Conditions: Sepsis|Septic Shock
Interventions: DEVICE: Efferon LPS NEO
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Study of Efficacy and Safety of Secukinumab Versus Placebo, in Combination With Glucocorticoid Taper Regimen, in Patients With Giant Cell Arteritis (GCA)
Status: ACTIVE_NOT_RECRUITING
Conditions: Giant Cell Arteritis (GCA)
Interventions: BIOLOGICAL: Secukinumab 300 mg|OTHER: Placebo|BIOLOGICAL: Secukinumab 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Bio-Clinical Effects of the (Sacubitril-Valsartan) Combination on Patients With Chronic Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Sacubitril-Valsartan|DRUG: Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Extension Period of PEG-somatropin (Pegylated-somatropin) in the Treatment of Children With Idiopathic Short Stature
Status: ACTIVE_NOT_RECRUITING
Conditions: Dwarfism
Interventions: DRUG: PEG-somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gold Laser Vs. Micro-Debriders for Functional Endoscopic Sinus Surgery
Status: WITHDRAWN
Conditions: Sinusitis
Interventions: DEVICE: Gold Laser|PROCEDURE: Microdebridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide and Low Dose Dexamethasone Versus Bortezomib, Lenalidomide and Low Dose Dexamethasone for Induction, in Patients With Previously Untreated Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Lenalidomide/Low dose Dex|DRUG: Bortezomib/Lenalidomide/ Low dose Dex|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of HRS-5041 Tablets Combined With Antitumor Therapy in Subjects With Advanced Prostate Cancer
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: HRS-5041 tablets|DRUG: Abiraterone Acetate tablets（II）|DRUG: Prednisone Acetate tablets|DRUG: Docetaxel Injection|DRUG: HRS-1167 tablets|DRUG: SHR2554 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Intravenous Lidocaine on Endometriosis Pain
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: IV Lidocaine|DRUG: IV diphenhydramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mobile Health Intervention to Promote Positive Infant Health Outcomes in Guatemala
Status: ACTIVE_NOT_RECRUITING
Conditions: Infant Development
Interventions: BEHAVIORAL: smartphone application to promote nurturing care|BEHAVIORAL: printed caregiving materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alleviating Headache and Pain in GWI With Neuronavigation Guided rTMS
Status: COMPLETED
Conditions: Gulf War Syndrome|Headache
Interventions: DEVICE: Repetitive transcranial magnetic stimulation|DEVICE: Repetitive transcranial magnetic stimulation (sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Gene Therapy With Modified Autologous Hematopoietic Stem Cells for the Treatment of Patients With Mucopolysaccharidosis Type I, Hurler Variant
Status: ACTIVE_NOT_RECRUITING
Conditions: Mucopolysaccharidosis IH
Interventions: GENETIC: Frozen autologous CD34+ hematopoietic stem and progenitor cells genetically modified with the lentiviral vector IDUA LV, encoding for the α-L-iduronidase cDNA, in their final formulation medium.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRE-Pregnancy Weight Loss And the Reducing Effect on CHILDhood Overweight - Aarhus
Status: RECRUITING
Conditions: Overweight and Obesity|Weight Loss|Pregnancy Related|Child Nutrition Sciences|Body Composition
Interventions: BEHAVIORAL: Weight loss intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase 3 Efficacy and Safety Laboratory Classroom Study in Pediatrics (6-12) With ADHD Using CTx-1301
Status: SUSPENDED
Conditions: ADHD|ADHD - Combined Type|Attention Deficit Hyper Activity|Attention Deficit Hyperactivity Disorder|Attention Deficit Disorder With Hyperactivity|Attention Deficit Hyperactivity Disorder Combined|Attention-deficit Hyperactivity
Interventions: DRUG: CTx-1301 - Dexmethylphenidate 6.25mg|DRUG: CTx-1301 - Dexmethylphenidate 12.5mg|DRUG: CTx-1301 - Dexmethylphenidate 18.75mg|DRUG: CTx-1301 - Dexmethylphenidate 25.0mg|DRUG: CTx-1301 - Dexmethylphenidate 31.25mg|DRUG: CTx-1301 - Dexmethylphenidate 37.5mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Thoracoabdominal Nerve Block With Serratus Intercostal Plane and Rectus Sheath Block in Cholecystectomy
Status: RECRUITING
Conditions: Pain Management
Interventions: PROCEDURE: Group M-TAPA|PROCEDURE: Group Serratus Intercostal Plane Block and Rectus Sheath Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Single-step Placenta Accreta Resective Technique Tourniqueted vs Absence, Conservative Uterine Surgery
Status: RECRUITING
Conditions: Placenta Accreta
Interventions: PROCEDURE: Uterovesical tourniquet before uterine devascularization steps|PROCEDURE: Conventional conservative surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Repeated Dose Study for the Investigation of Heritability of and Genetic Influences on Drug Pharmacokinetics
Status: COMPLETED
Conditions: Drug Biotransformation|Membrane Transport
Interventions: DRUG: Codeine|DRUG: Midazolam|DRUG: Pravastatin|DRUG: Torsemide|DRUG: Talinolol|DRUG: Caffeine|DRUG: Metoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Asthma Self-Management in Older Adults
Status: COMPLETED
Conditions: Asthma|Aged
Interventions: BEHAVIORAL: Self management intervention|BEHAVIORAL: placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Medication and Counseling for Controlled Drinking
Status: UNKNOWN
Conditions: Alcohol Dependence|Alcohol Abuse
Interventions: DRUG: Naltrexone|BEHAVIORAL: Modified Behavioral Self-Control Psychotherapy|BEHAVIORAL: Brief Behavioral Compliance Enhancement Therapy|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Ibandronate - Zoledronate Regarding Nephrotoxicity in Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Ibandronate|DRUG: Zoledronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety, Tolerability and Pharmacokinetic Profile of PBF-999 "After Multiple Oral Doses" in Healthy Volunteers
Status: TERMINATED
Conditions: Huntington Disease
Interventions: DRUG: PBF-999 / 160 mg|DRUG: PBF-999 / 320 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Treatment for Helicobacter Pylori Infection in Preschooler by Yoghurt With LG21
Status: ACTIVE_NOT_RECRUITING
Conditions: H. Pylori Infection
Interventions: DIETARY_SUPPLEMENT: Meiji Yogurt Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Laparoscopic Colectomies In Management of Colonic Cancers
Status: UNKNOWN
Conditions: Laparoscopic Colectomy|Cancer Colon|Intracorporeal Anastomosis
Interventions: PROCEDURE: laparoscopic intracorporeal versus extracorporeal anastomosis for right and left hemicolectomies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Algorithmic Protamine Dosing for Reversal of Heparin After Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Heart Diseases|Cardiovascular Diseases
Interventions: PROCEDURE: PRODOSE Algorithm|PROCEDURE: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Examine Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Exenatide Once Weekly in Japanese Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: exenatide once weekly|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study to Evaluate the Safety, Tolerability, PK and PD of Voxelotor in Patients With SCD
Status: TERMINATED
Conditions: Sickle Cell Disease
Interventions: DRUG: Voxelotor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Chlorhexidine Gel Associated With Photodynamic Therapy in the Treatment in Diabetic Participants
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 2|Periodontitis, Adult|Periodontitis
Interventions: PROCEDURE: Periodontal treatment|PROCEDURE: Periodontal procedure|PROCEDURE: Oral treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immobilization Versus Immediate Motion After Anterior Submuscular Ulnar Nerve Transposition
Status: WITHDRAWN
Conditions: Cubital Tunnel Syndrome
Interventions: PROCEDURE: Immobilization followed by protected range of motion|PROCEDURE: Immediate range of motion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre- and Apnoeic Oxygenation for RSI in ED
Status: COMPLETED
Conditions: Intubation|Oxygen Inhalation Therapy
Interventions: DEVICE: High-flow nasal cannulae (HFNC) oxygenation|DEVICE: Non-rebreather mask and standard nasal cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Application of the Umbilical Cord Mesenchymal Stem Cells in the Complex Treatment of Non-ischemic Heart Failure
Status: COMPLETED
Conditions: Chronic Heart Failure|Non-ischemic Cardiomyopathy|Non-ischemic Dilated Cardiomyopathy
Interventions: PROCEDURE: Cardiac catheterization|BIOLOGICAL: Intracoronary administration of the umbilical cord-derived mesenchymal stromal cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EaseAlert: Tactile Firefighter Alerting System
Status: RECRUITING
Conditions: Heart Rate|Sleep Habit|Sleep
Interventions: DEVICE: Legacy Alerting System|DEVICE: Intervention 2: EaseAlert Standalone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Peroperative Administration of Tranexamic Acid in Roux-en-Y Gastric Bypass and One-anastomosis Gastric Bypass
Status: NOT_YET_RECRUITING
Conditions: Hemorrhage|Bleeding
Interventions: DRUG: Tranexamic Acid Injection [Cyklokapron]|DRUG: Sodium chloride 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment for Schizophrenia Patients With Auditory Hallucinations
Status: COMPLETED
Conditions: Schizophrenia|Transcranial Magnetic Stimulation|Functional Magnetic Resonance Imaging
Interventions: DEVICE: transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Wearable Vibration Effect on Biomechanics and Biomarkers After ACL Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injuries
Interventions: DEVICE: Active vibratory knee device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Safety, Tolerability, PK and Preliminary PD of SSS11 in Chinese Healthy Adult Volunteers
Status: UNKNOWN
Conditions: Gout
Interventions: DRUG: PEGylated recombinant candida urate oxidase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of The Products Used In Nazogastric Tube Fixation
Status: UNKNOWN
Conditions: Skin Injury
Interventions: DEVICE: Water-based barrier tape|DEVICE: Hydrocolloid barrier tape|DEVICE: Silk tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Unilateral TMJ Discectomy Without Interposal Material in Patients With Disc Perforation or Fragmentation
Status: COMPLETED
Conditions: Temporomandibular Disorders
Interventions: PROCEDURE: TMJ unilateral discectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Efficacy and Safety of Durvalumab Plus BCG Compared to the Standard Therapy With BCG in Non-muscle Invasive Bladder Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-muscle-invasive Bladder Cancer
Interventions: BIOLOGICAL: Durvalumab (MEDI4736)|BIOLOGICAL: Bacillus Calmette-Guerin (BCG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Splint and Laser in Patients Without Disc Displacement With Reduction
Status: COMPLETED
Conditions: TMJ Disc Disorder
Interventions: DEVICE: stabilization splint|DEVICE: laser therapy|DEVICE: stabilization splint and laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD22
Status: UNKNOWN
Conditions: Hematopoietic/Lymphoid Cancer|Adult Acute Lymphoblastic Leukemia in Remission|B-cell Adult Acute Lymphoblastic Leukemia|B-Cell Chronic Lymphocytic Leukemia in Relapse (Diagnosis)|Prolymphocytic Leukemia|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Refractory Chronic Lymphocytic Leukemia|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Chronic Lymphocytic Leukemia|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Chronic Lymphocytic Leukemia|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma
Interventions: BIOLOGICAL: anti-CD19/22-CAR vector-transduced T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Integrated-management Program to Control Health-related Quality of Life Among Patients With Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: OTHER: Internet-Based integrated-management Program|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CR Aim #2 - AT1 Receptor Blockade & ACE Inhibition Effect on Humoral Function
Status: COMPLETED
Conditions: Cardiorenal Syndrome (CRS)
Interventions: DRUG: Candesartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nasal and Oronasal Mask in Severe OSA Patients With Nasal Free Airflow of Obstruction
Status: COMPLETED
Conditions: Obstructive Sleep Apnea of Newborn
Interventions: DEVICE: Nasal CPAP|DEVICE: Oronasal CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Vasoactive Intestinal Peptide in Patients With Acute Respiratory Distress Syndrome and Sepsis
Status: COMPLETED
Conditions: Sepsis|Respiratory Distress Syndrome|Respiratory Distress Syndrome, Adult
Interventions: DRUG: vasoactive intestinal peptide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of Anti-Cancer Drug, ZEN003694 (ZEN-3694) and PD-1 Inhibitor (Pembrolizumab), to Standard Chemotherapy (Nab-Paclitaxel) Treatment in Patients With Advanced Triple-Negative Breast Cancer
Status: SUSPENDED
Conditions: Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Locally Advanced Triple-Negative Breast Carcinoma|Metastatic Triple-Negative Breast Carcinoma|Unresectable Triple-Negative Breast Carcinoma
Interventions: DRUG: BET Bromodomain Inhibitor ZEN-3694|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Nab-paclitaxel|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IRIS-Onyx Cohort in the IRIS-DES Registry
Status: RECRUITING
Conditions: Coronary Artery Disease|Arterial Occlusive Diseases|Cardiovascular Diseases|Percutaneous Transluminal Angioplasty
Interventions: DEVICE: Onyx Drug Eluting Stent group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Blood Lactate Concentrations With and Without Exercise in Parkinson's Disease and Multiple Sclerosis Patients
Status: COMPLETED
Conditions: Parkinson's Disease|Multiple Sclerosis
Interventions: DEVICE: pro5 AIRdaptive Power Plate (Badhoevedorp, The Netherlands)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACT vs CQ With Tafenoquine for P. Vivax Mono-infection
Status: RECRUITING
Conditions: Malaria|Malaria, Vivax|Plasmodium Vivax Malaria
Interventions: DRUG: Dihydroartemisinin-piperaquine plus tafenoquine (450 mg adult dose)|DRUG: Chloroquine plus Tafenoquine (450 mg adult dose)|DRUG: Artemether-Lumefantrine plus Tafenoquine (450 mg adult dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Dose Escalation Study for Advanced Liver Cancer
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: RADIATION: 3DCRT/IMRT|RADIATION: 3DCRT/IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spinal Cord Neuromodulation for Spinal Cord Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Spinal Cord Injury|Tetraparesis|Tetraplegia
Interventions: DEVICE: Epidural Stimulation|DRUG: Buspirone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of MK-8808 for Participants With Follicular Lymphoma (MK-8808-001)
Status: TERMINATED
Conditions: Follicular Lymphoma
Interventions: DRUG: MK-8808|DRUG: cyclophosphamide|DRUG: vincristine|DRUG: prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optic Nerve Sheath Ultrasound in Giant Cell Arteritis
Status: NOT_YET_RECRUITING
Conditions: Giant Cell Arteritis|Anterior Ischemic Optic Neuropathy|Optic Neuropathy, Ischemic
Interventions: DIAGNOSTIC_TEST: Optic nerve ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: hTERT Immunotherapy Alone or in Combination With IL-12 DNA Followed by Electroporation in Adults With Solid Tumors at High Risk of Relapse
Status: COMPLETED
Conditions: Breast Cancer|Lung Cancer|Pancreatic Cancer|Head and Neck Cancer|Ovarian Cancer|ColoRectal Cancer|Gastric Cancer|Esophageal Cancer|HepatoCellular Carcinoma
Interventions: BIOLOGICAL: INO-1400|BIOLOGICAL: INO-9012|BIOLOGICAL: INO-1401
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Femoral or Sciatic Nerve Block to Provide Analgesia After Proximal Tibial Osteotomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Femoral nerve block with ropivacaine 0.5%, 20 ml|PROCEDURE: Sciatic nerve block with ropivacaine 0.5%, 20 ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver Transplantation
Status: COMPLETED
Conditions: End Stage Liver DIsease|Liver Failure
Interventions: DEVICE: VitaSmart Liver Machine Perfusion System|OTHER: Static cold storage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT