pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Transversus Abdominis Muscle Release Versus Mesh Only Repair in the Treatment of Complex Ventral Wall Hernia
Status: UNKNOWN
Conditions: Hernia, Ventral|Hernia Incisional|Hernia, Abdominal
Interventions: PROCEDURE: Posterior Component Separation with Transversus Abdominis Muscle Release|PROCEDURE: Mesh-only repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DRAGON 1- Training, Accreditation, Implementation and Safety Evaluation of Combined PVE/HVE
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer Liver Metastases
Interventions: PROCEDURE: Portal and Hepatic Vein Embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Valproate on Ethanol Withdrawal
Status: UNKNOWN
Conditions: Alcohol Dependence|Alcohol Withdrawal Syndrome|Trauma|Heavy Drinking|Alcohol Use Disorder
Interventions: DRUG: Valproate|DRUG: Lorazepam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Local Infiltration Analgesia Vs. Interscalene Block in Total Shoulder Arthorplasty
Status: COMPLETED
Conditions: Shoulder Osteoarthritis|Cuff Tear Arthropathy|Massive Rotator Cuff Tear
Interventions: PROCEDURE: Local infiltration analgesia|PROCEDURE: Interscalene block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gut Health, Inflammation, Hormones
Status: COMPLETED
Conditions: Aging Well
Interventions: DIETARY_SUPPLEMENT: VMK223|DIETARY_SUPPLEMENT: Cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Relative Bioavailability and Food Effect Study of Losmapimod 15 mg Tablets
Status: COMPLETED
Conditions: Healthy Adult Subjects
Interventions: DRUG: Losmapimod 15 mg oral tablet|DRUG: Losmapimod two 7.5 mg oral tablets|DRUG: Losmapimod one 15 mg oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Paclitaxel in Patients With Ovarian Cancer
Status: COMPLETED
Conditions: Epithelial Ovarian Cancer|Primary Peritoneal Cancer|Fallopian Tube Cancer
Interventions: DRUG: Paclical®|DRUG: Taxol®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long- Term Transcranial Direct Current Stimulation in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: DEVICE: Anodal tDCS|DEVICE: SHAM tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Mixed Bowel Prep (2L PEG + Bisacodyl) Versus PEG With Ascorbate
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: 2L PEG-CS plus bisacodyl|DRUG: 2L PEG-ASC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PTK 787 and Gleevec in Patients With AML, AMM, and CML-BP
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Agnogenic Myeloid Metaplasia|Chronic Myelogenous Leukemia
Interventions: DRUG: Imatinib Mesylate (Gleevec)|DRUG: PTK 787 (vatalanib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of PSMA in HER2- AR+ Metastatic Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|HER2-negative Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: 18F-DCFPyL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Definition, Quantification, and Utility of Biomarkers of Repetitive Brain Injury in Predicting Concussion and Other Long-Term Injury Risks in Patients With Atrial Fibrillation (Concussion AF)
Status: COMPLETED
Conditions: Cognitive Change
Interventions: OTHER: Biomarkers of Dementia and Cognitive Decline
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Post-cesarean Pain Control Via Continuous Infusion of Ropivacain et Diclogenac Into the Wound Versus Intathecal Morphine
Status: WITHDRAWN
Conditions: Cesarean Section
Interventions: DRUG: Reference|DRUG: Experimental
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanism-based Choice of Therapy: Can Treatments Success in Fibromyalgia Patients be Coupled to Psychophysical Pain Modulation Profile?
Status: UNKNOWN
Conditions: Fibromyalgia
Interventions: DRUG: Duloxetine|DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of JVS-100 Administered to Adults With Critical Limb Ischemia
Status: COMPLETED
Conditions: Critical Limb Ischemia
Interventions: BIOLOGICAL: JVS-100(4 mg) or placebo/8 injections|BIOLOGICAL: JVS-100(8 mg) or placebo/8 injections|BIOLOGICAL: JVS-100(8 mg) or placebo/16 injections|BIOLOGICAL: JVS-100(16 mg) or placebo/16 injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Efficacy of Current Treatments for Reducing Postoperative Ileus
Status: COMPLETED
Conditions: Post-operative Ileus
Interventions: DIETARY_SUPPLEMENT: olive oil|DIETARY_SUPPLEMENT: olive oil and chewing gum|DIETARY_SUPPLEMENT: chewing gum|DIETARY_SUPPLEMENT: water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study on the Immune Response and Safety of an Adjuvanted Human Papillomavirus Vaccine When Given to Healthy Women 16 to 26 Years of Age
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Intraepithelial Neoplasia
Interventions: BIOLOGICAL: HPV9 High formulation|BIOLOGICAL: HPV9 Medium formulation|BIOLOGICAL: HPV9 Low formulation|BIOLOGICAL: Gardasil 9
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Determine the Optimal Dose of Tildrakizumab (SCH 900222/MK-3222) for the Treatment of Moderate-to-severe Chronic Plaque Psoriasis (P05495) (MK-3222-003)
Status: COMPLETED
Conditions: Psoriasis
Interventions: BIOLOGICAL: tildrakizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic/Pharmacodynamic Study of MP-513 With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: MP-513|DRUG: MP-513|DRUG: Placebo of MP-513
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Cancer of the Esophagus
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: chemotherapy|DRUG: cisplatin|DRUG: fluorouracil|RADIATION: low-LET electron therapy|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Hyperpolarized C-13 Pyruvate as a Biomarker in Patients With Advanced Solid Tumor Malignancies
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Pyruvate (13C)|DEVICE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neoadjuvant mFOLFOXIRI Plus Bevacizumab in Patients With High-Risk Locally Advanced Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer
Interventions: DRUG: Neoadjuvant chemotherapy with mFOLFOXIRI plus bevacizumab|PROCEDURE: Restaging|RADIATION: Concomitant Chemoradiotherapy|PROCEDURE: Surgery|RADIATION: Chemoradiotherapy (only when patients with MRF involved or ycT4a/b by restaging)|DRUG: Induction chemotherpay with FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internal Fixation or Joint Replacement Therapy for Aged Hip Fracture Patients
Status: UNKNOWN
Conditions: Intertrochanteric Fractures
Interventions: PROCEDURE: Joint replacement surgery|PROCEDURE: Intramedullary nail fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Recombinant Human Growth Hormone Injection in Patients With Prader-Willi Syndrome
Status: UNKNOWN
Conditions: Prader-Willi Syndrome
Interventions: DRUG: Recombinant Human Growth Hormone (rhGH) Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: [18F]DASA-23 and PET Scan in Evaluating Pyruvate Kinase M2 Expression in Patients With Intracranial Tumors or Recurrent Glioblastoma and Healthy Volunteers
Status: TERMINATED
Conditions: Healthy Subject|Intracranial Neoplasm|Glioblastoma
Interventions: DRUG: Fluorine F 18 DASA-23|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Peer to Peer Mentoring: Facilitating Individuals With Early Inflammatory Arthritis to Manage Their Arthritis: Peer Mentoring Program
Status: COMPLETED
Conditions: Early Inflammatory Arthritis|Chronic Disease
Interventions: BEHAVIORAL: peer support
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Behavioral Economics and Adherence in Teens (BEAT!)
Status: COMPLETED
Conditions: Epilepsy|Adherence, Medication
Interventions: BEHAVIORAL: Automated Digital Reminders|BEHAVIORAL: Individualized Adherence Feedback Report|BEHAVIORAL: Individual Adherence Feedback Report with Social Norms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Sphenopalatine Ganglion Block for Post-Dural Puncture Headache
Status: TERMINATED
Conditions: Post-Dural Puncture Headache|Sphenopalatine Ganglion Block
Interventions: DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient-tailored Transcranial Direct Current Stimulation to Improve Stroke Rehabilitation
Status: RECRUITING
Conditions: Ischemic Stroke|Upper Extremity Hemiparesis
Interventions: DEVICE: Active Transcranial Direct Current Stimulation|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Regorafenib With Tislelizumab in Patients With Selected Mismatch Repair-Proficient/Microsatellite Stable Cancers
Status: WITHDRAWN
Conditions: Anal Squamous Cell Carcinoma|Colorectal Neoplasms|Soft Tissue Sarcoma|Malignant Pleural Mesothelioma|Small Cell Lung Carcinoma|Castrate Resistant Prostate Cancer|Neuroendocrine Carcinoma of Prostate|Gastroenteropancreatic Neuroendocrine Neoplasm
Interventions: COMBINATION_PRODUCT: Regorafenib in combination with Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long Term Extension Study Evaluating ACC-001 With QS-21 in Subjects With Mild to Moderate Alzheimer's Disease
Status: TERMINATED
Conditions: Alzheimer Disease
Interventions: BIOLOGICAL: ACC-001+ QS21 (3mcg)|BIOLOGICAL: ACC-001 (10 mcg) + QS-21|BIOLOGICAL: ACC-001+QS-21 (30mcg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sympathetic Activity and Cardiometabolic Complications
Status: COMPLETED
Conditions: Catecholamine; Overproduction|Catecholamine; Secretion|Metabolic Syndrome|Hypertensive Heart Disease|Hypertensive Kidney Disease|Diabetes Mellitus, Type 2|Hypertension,Essential
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CARE1 Pragmatic Clinical Trial
Status: RECRUITING
Conditions: Metastatic Kidney Cancer|Metastatic Kidney Carcinoma
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab|DRUG: Pembrolizumab|DRUG: Cabozantinib|DRUG: Axitinib|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Protective Effect of Activated Charcoal and Probiotic Against Progression of Chronic Kidney Disease
Status: UNKNOWN
Conditions: Uremic Toxin
Interventions: DRUG: Activated Charcoal|DIETARY_SUPPLEMENT: Probiotic|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Myopia Control in Children: Comparison of Defocus Incorporated Multiple Segments® Lenses Versus Atropine 0.05% Eyedrops
Status: RECRUITING
Conditions: Myopia
Interventions: DEVICE: Defocus Incorporated Multiple Segments® (DIMS®) lenses|DRUG: Atropine 0.05% eyedrops|DEVICE: Monofocal lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supplements, Placebo, or Rosuvastatin Study
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: Fish Oil, Cinnamon, Garlique,Turmeric, Plant Sterol, Red Yeast Rice|DRUG: Rosuvastatin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Grazoprevir (MK-5172), Elbasvir (MK-8742), and Sofosbuvir for Chronic Infection With Hepatitis C Virus Genotypes 1 and 3 (MK-5172-074)
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Grazoprevir/Elbasvir FDC|DRUG: Sofosbuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eltrombopag Olamine in Increasing Platelet Counts in Patients Undergoing Transplant
Status: COMPLETED
Conditions: Bone Marrow Transplantation Recipient|Cord Blood Transplant Recipient|Hematopoietic Cell Transplantation Recipient
Interventions: DRUG: Eltrombopag Olamine|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ESTEEM - Effect of Simple, Targeted Diet in Pregnant Women With Metabolic Risk Factors on Pregnancy Outcomes
Status: COMPLETED
Conditions: Pre-eclampsia|Obesity|Raised Lipids|High Blood Pressure|Insulin Resistance|Gestational Diabetes|Small for Gestational Age|Stillbirth
Interventions: BEHAVIORAL: Targeted ESTEEM diet|OTHER: Non-randomised cohort
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Copper Concentration & Histopathologic Changes in Liver Biopsy in Participants With Wilson Disease Treated With ALXN1840
Status: COMPLETED
Conditions: Wilson Disease
Interventions: DRUG: Bis-Choline Tetrathiomolybdate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Musculoskeletal Microcirculation With Ultrasound
Status: TERMINATED
Conditions: Standardised Claudication Treadmill Test
Interventions: PROCEDURE: Contrast enhanced ultrasound|BEHAVIORAL: Treadmill test|PROCEDURE: Contrast enhanced ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Oxygenation Methods and Non-invasive Ventilation in Patients With Acute Respiratory Failure and a do Not Intubate Order
Status: UNKNOWN
Conditions: Acute Respiratory Failure|Cancer|Hematologic Malignancy|Cardiac Insufficiency|Chronic Respiratory Insufficiency
Interventions: DEVICE: NIV|DEVICE: NFHC-O2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy Study of Zamtocabtagene Autoleucel (MB-CART2019.1) in Pediatric Patients With Relapsed or Refractory B-Cell Neoplasms
Status: NOT_YET_RECRUITING
Conditions: B-Cell Neoplasm
Interventions: DRUG: zamtocabtagene autoleucel (MB-CART2019.1)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smectite Gel and Probiotic for Obesity and Insulin Resistance
Status: COMPLETED
Conditions: Obesity|Insulin Resistance|Insulin Sensitivity|Type2 Diabetes Mellitus|Visceral Obesity
Interventions: DIETARY_SUPPLEMENT: Symbiter-Smectite|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TOnicity of Perioperative Maintenance SoluTions
Status: COMPLETED
Conditions: Thoracic Diseases|Water-Electrolyte Imbalance|Fluid Overload|Fluid Retention|Sodium Disorder|Potassium Disorders|Chloride Disorder
Interventions: DRUG: NaCl 0.9% in Glucose 5% + 40mmol/L Potassium|DRUG: Glucion 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Assess the Efficacy and Safety of Potassium Clavulanate/Amoxicillin in Children With Acute Bacterial Rhinosinusitis
Status: COMPLETED
Conditions: Sinusitis, Acute
Interventions: DRUG: Amoxicillin-Potassium Clavulanate Combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of the Neurodynamic Slider and Tensioner Mobilisation Techniques on Sympathetic Nervous System Function: A Randomised Controlled Trial
Status: COMPLETED
Conditions: Health Care Acceptor
Interventions: OTHER: Neurodynamic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Atrial Rate-adaptive Pacing on Exercise Capacity in Patients With Chronic Heart Failure Complicated by Chronotropic Incompetence
Status: UNKNOWN
Conditions: Heart Failure|Exercise Tolerance
Interventions: OTHER: Rate-adaptive pacemaker programming|OTHER: VVI at 40 bpm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Before to Surgical Removal of a Recalcitrant Morton´s Neuroma
Status: ACTIVE_NOT_RECRUITING
Conditions: Morton Neuroma|Radriofrequency
Interventions: PROCEDURE: Radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bacterial Pneumonia Score (BPS) Guided Antibiotic Use in Children With Pneumonia and Pneumococcal Vaccine
Status: COMPLETED
Conditions: Community Acquired Pneumonia
Interventions: BEHAVIORAL: BPS|BEHAVIORAL: Guideline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: DNA-based Influenza Vaccine in the Elderly
Status: COMPLETED
Conditions: Influenza, Human|Orthomyxoviridae Infections|RNA Virus Infections|Virus Diseases|Respiratory Tract Infections|Respiratory Tract Diseases
Interventions: BIOLOGICAL: FVH1 - a DNA-based influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sintilimab in FH-deficient Renal Cell Carcinoma
Status: UNKNOWN
Conditions: Renal Cell Carcinoma|FH-deficient|Sintilimab
Interventions: DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACT-GLOBAL THROMBOLYSIS (ACT-WHEN-001) Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632
Status: NOT_YET_RECRUITING
Conditions: Acute Ischemic Stroke AIS|Stroke Acute|Stroke, Acute, Stroke Ischemic
Interventions: DRUG: Tenecteplase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacist Intervention for Monitoring and Treating Hypertension Using Bidirectional Texting
Status: COMPLETED
Conditions: Hypertension
Interventions: OTHER: Experimental: Pharmacist-Bidirectional Texting Group|OTHER: Active Comparator: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of GSP 301 Nasal Spray in Children (Aged 6 to Under 12 Years) With Seasonal Allergic Rhinitis (SAR)
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis (SAR)
Interventions: DRUG: GSP 301 NS|DRUG: GSP 301 Placebo NS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Urinary Catheterization Training on Skills, Satisfaction and Self-Confidence in Nursing Students
Status: NOT_YET_RECRUITING
Conditions: Catheter-Related Infections|Urinary Catheterization
Interventions: OTHER: Use of simulation in urinary catheterization training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Vascular Healing After Implantation of FANTOM Bioresorbable Scaffold in STEMI: A FANTOM STEMI Study
Status: UNKNOWN
Conditions: STEMI|Cardiovascular Disease|Bioresorbable Scaffold
Interventions: DEVICE: PCI with Phantom Bioresorbable Scaffold
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Tolerability of the Broad-spectrum Probiotic Medicine "AS-Probionorm"
Status: COMPLETED
Conditions: Intestinal Infections|Dysbacteriosis
Interventions: DRUG: "AS-Probionorm"
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional and Structural Imaging and Motor Control in Spinocerebellar Ataxia
Status: COMPLETED
Conditions: Spinocerebellar Ataxia
Interventions: BEHAVIORAL: Error-reduction|BEHAVIORAL: International Cooperative Ataxia Rating Scale|BEHAVIORAL: Scale for the Assessment and Rating of Ataxia|BEHAVIORAL: Beck Depression Inventory, 2nd Ed|BEHAVIORAL: Stroop|BEHAVIORAL: Purdue Pegboard|BEHAVIORAL: Brief Test of Attention|BEHAVIORAL: 6-minute Walk|BEHAVIORAL: Hand Grip Dynamometer|BEHAVIORAL: Montreal Cognitive Assessment|BEHAVIORAL: Physical Performance Function|BEHAVIORAL: Biomechanical Assessments of Dysmetria|BEHAVIORAL: Neurophysiological assessment of brain activity|BEHAVIORAL: Biomechanical gait analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: fMRI-based Neurofeedback to Relieve Drug-resistant Auditory Hallucinations
Status: NOT_YET_RECRUITING
Conditions: Schizophrenia|Hallucinations, Auditory|Hallucinations, Visual
Interventions: OTHER: Active neurofeedback procedure|OTHER: Sham neurofeedback procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Exercise Training Intensity on Fitness and Insulin Sensitivity in African Americans
Status: COMPLETED
Conditions: Obesity|Insulin Resistance|Sedentary Lifestyle
Interventions: BEHAVIORAL: Moderate intensity exercise training (MOD-INT)|BEHAVIORAL: High Intensity exercise training (HI-INT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prescription of Letrozole for Uterine Myoma
Status: RECRUITING
Conditions: Leiomyoma, Uterine|Leiomyoma|Fibroid|Fibroid Uterus
Interventions: DRUG: Letrozole 2.5mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Project Sueño: Sleep & Understanding Early Nutrition in Obesity
Status: RECRUITING
Conditions: Infant Overweight|Infant Obesity|Infant Overnutrition|Infant Development|Metabolic Syndrome|Diabetes Mellitus Risk
Interventions: BEHAVIORAL: Centering Parenting|BEHAVIORAL: Bright by Text
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vismodegib in Treating Patients With Basal Cell Carcinoma (BCC)
Status: COMPLETED
Conditions: Basal Cell Carcinoma of the Skin|Recurrent Skin Cancer
Interventions: DRUG: vismodegib|PROCEDURE: Mohs surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Bevacizumab for the Treatment of Central Serous Chorioretinopathy
Status: WITHDRAWN
Conditions: Central Serous Chorioretinopathy
Interventions: DRUG: Intravitreal injection of Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patients With Relapsed Ovarian Cancer (2nd and 3rd Line) Treated With Chemotherapy According to AGO Guidelines
Status: TERMINATED
Conditions: Ovarian Cancer
Interventions: DRUG: Standard chemotherapy|DRUG: Romiplostim|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preservative-Free MK2452 (Tafluprost) for Open-Angle Glaucoma/Ocular Hypertension (MK2452-001)(COMPLETED)
Status: COMPLETED
Conditions: Open-angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Preservative-Free Tafluprost|DRUG: Comparator: timolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Captisol-Enabled™ Iohexol and Omnipaque™ in Patients With Impaired Renal Function Undergoing Coronary Angiography
Status: WITHDRAWN
Conditions: Contrast-induced Nephropathy
Interventions: DRUG: CE-Iohexol|DRUG: Iohexol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Symbicort Rapihaler Therapeutic Equivalence Study
Status: COMPLETED
Conditions: Bronchial Asthma
Interventions: DRUG: Symbicort Turbuhaler|DRUG: Symbicort pMDI|DRUG: Pulmicort Turbuhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development and Feasibility Test of an Ecological Momentary Intervention (EMI) - ReApp, to Increase Reappraisal.
Status: COMPLETED
Conditions: Stress
Interventions: DEVICE: Reappraisal training|DEVICE: Ecological Momentary Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Opioid Free Versus Opioid Balanced Anesthesia in Ophthalmic Surgery
Status: NOT_YET_RECRUITING
Conditions: Anesthesia and Analgesia|Anesthesia, Endotracheal
Interventions: DRUG: Dexmedetomidine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Therapy With Thalidomide for Chemoembolization in Advanced Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Thalidomide|DRUG: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Depocyte in the Treatment of CNS Relapse in Patients With Lymphoblastic Leucemia or Very Aggressive Lymphoma
Status: COMPLETED
Conditions: Lymphoblastic Leukemia|Lymphoma
Interventions: DRUG: Depocyte®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Dose Safety Study for Compound to Treat Anemia in Patients With Renal Impairment
Status: COMPLETED
Conditions: Kidney Disease
Interventions: DRUG: GSK1278863A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Determine the Performance of the Astron and Pulsar-18 Stents in Europe
Status: UNKNOWN
Conditions: Peripheral Artery Disease|Peripheral Vascular Disease
Interventions: DEVICE: Astron/Pulsar-18 stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Olaparib in Treating Patients With Metastatic Biliary Tract Cancer With Aberrant DNA Repair Gene Mutations
Status: RECRUITING
Conditions: Bile Duct Adenocarcinoma|Fanconi Anemia Complementation Group Gene Mutation|Metastatic Bile Duct Carcinoma|PTEN Gene Deletion
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exenatide and Impaired Hypoglycaemic Awareness in Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Hypoglycemia
Interventions: DRUG: Exenatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b Study to Assess the Safety, Tolerability, PK and PD of MG1113 in Hemophilia Patient
Status: RECRUITING
Conditions: Hemophilia
Interventions: BIOLOGICAL: MG1113
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spasticity and Functional Recovery After SCI
Status: ENROLLING_BY_INVITATION
Conditions: Acute Spinal Cord Injury|Spinal Cord Injuries
Interventions: OTHER: Measures of spasticity, connectivity and analysis of single nucleotide polymorphisms and biomarkers of inflammation|OTHER: Analysis of biomarkers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial of the Safety, Tolerability, and Pharmacodynamics of CVL-871 in Subjects With Dementia-Related Apathy
Status: RECRUITING
Conditions: Apathy in Dementia
Interventions: DRUG: CVL-871 1.0 mg|DRUG: CVL-871 3.0 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess The Relative Bioavailability of New Tablet Formulations of GSK1265744 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: GSK1265744 Reference formulation|DRUG: GSK1265744 New formulation 1|DRUG: GSK1265744 New formulation 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Treating Obese and Lean Patients With Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea|Obesity
Interventions: DEVICE: Positive Airway Pressure During Sleep (ResMed S9 Elite)|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of VELCADE for Relapsed or Refractory T-cell Prolymphocytic Leukemia
Status: WITHDRAWN
Conditions: Leukemia|Acute Lymphocytic Leukemia
Interventions: DRUG: Velcade
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Block of the Sphenopalatine Nerve Ganglion for Postoperative Analgesia
Status: UNKNOWN
Conditions: Surgery|Anesthesia, Local|Postoperative Pain
Interventions: PROCEDURE: sphenopalatine ganglion block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Risk Factors Likely to Influence Immuno of Combined Hepatitis A & B Vacc vs Monovalent Hepatitis A & B Vacc
Status: COMPLETED
Conditions: Hepatitis B|Hepatitis A
Interventions: BIOLOGICAL: TWINRIX™|BIOLOGICAL: Engerix™-B|BIOLOGICAL: HAVRIX™|BIOLOGICAL: HB VAX PRO™|BIOLOGICAL: Vaqta™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Radial Artery Dilation Study: The Effect of Topical Administration of Nitroglycerin and Lidocaine Versus Lidocaine Alone of the Radial Artery Diameter
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Nitroglycerin 15mg|DRUG: Nitroglycerin 30mg|DRUG: Lidocaine 20mg|DRUG: Lidocaine 40mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Evaluation of the Effect of 10% Lidocaine Spray Undergoing Coronary Artery Bypass Graft Operation
Status: COMPLETED
Conditions: Cardiovascular Diseases|Lidocaine Causing Adverse Effects in Therapeutic Use|Tracheal Intubation Morbidity
Interventions: DRUG: Orotracheal Lidocaine Oral Spray application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transvaginal Human Acellular Dermal Matrix for Prolapse Treatment
Status: NOT_YET_RECRUITING
Conditions: Prolapse; Female|Prolapse Genital|Prolapse Uterovaginal
Interventions: PROCEDURE: Vaginal hysterectomy plus matrix reinforcement and sacrospinous fixation with Anchorsure® device|PROCEDURE: Vaginal hysterectomy plus anterior colporrhaphy|PROCEDURE: Vaginal hysterectomy plus sacrospinous fixation with Anchorsure® device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trilaciclib, a CDK 4/6 Inhibitor, in Patients With Advanced/Metastatic Bladder Cancer Receiving Chemotherapy Then Avelumab
Status: TERMINATED
Conditions: Urothelial Carcinoma|Bladder Cancer|Myelosuppression Adult|Chemotherapy-induced Neutropenia|Metastatic Bladder Cancer
Interventions: DRUG: Trilaciclib|DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Adipose-derived Regenerative Cells Injection for Treatment of Osteoarthritis of the Facet Joint
Status: RECRUITING
Conditions: Osteoarthritis of Facet Joint of Lumbar Spine
Interventions: DEVICE: Adipose-derived stem cell injection|DRUG: Corticosteroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Cimetidin for Acute - Extrinsic Atopic Dermatitis Treated With Standard Therapy
Status: UNKNOWN
Conditions: Atopic Dermatitis|Immunoglobulin E Concentration, Serum
Interventions: DRUG: Cimetidine|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of the Efficacy and Safety of BCD-201 and Keytruda in Subjects With Advanced Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma (Skin)
Interventions: DRUG: BCD-201|DRUG: Keytruda
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Unilateral Posterolateral Approach for Spondylodiskitis
Status: COMPLETED
Conditions: Discitis
Interventions: PROCEDURE: Unilateral Posterolateral Approach and Debridement|OTHER: Titanium cage insertion supplemented by screw fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy and Safety of Pegozafermin in Subjects With Severe Hypertriglyceridemia
Status: RECRUITING
Conditions: Severe Hypertriglyceridemia
Interventions: DRUG: Pegozafermin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of AK104 Plus Lenvatinib and TACE in HCC
Status: RECRUITING
Conditions: Unresectable, Non-metastatic Hepatocellular Carcinoma
Interventions: BIOLOGICAL: AK104|DRUG: Lenvatinib|PROCEDURE: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of an Oral Probiotic in Healthy Adults
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DIETARY_SUPPLEMENT: Streptococcus salivarius DB-B5|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Complete Median Nerve Transection With Clinical, Electroneuromyographic and Diffusion Tensor Imaging
Status: UNKNOWN
Conditions: Wound, Healed (Morphologic Abnormality)|Injury of Median Nerve
Interventions: OTHER: physical examination|OTHER: DTI|OTHER: ENMG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fruquintinib Combined With TAS-102 in the Treatment of Patients With Advanced Metastatic CRC
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: fruquintinib plus TAS-102
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of ACU-D1 in HPV Associated Vulvar and Perianal Lesions in People With HIV
Status: NOT_YET_RECRUITING
Conditions: Human Papilloma Virus|Human Immunodeficiency Virus|Anal Intraepithelial Neoplasia|High-Grade Squamous Intraepithelial Lesions
Interventions: DRUG: Dose Level 1 ACU-D1 ointment|DRUG: Dose Level 2 ACU-D1 ointment|DRUG: Dose Level 3 ACU-D1 ointment|PROCEDURE: Vulvar/ Perianal Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Macular Edema Secondary to Central Retinal or Hemiretinal Vein Occlusion
Status: COMPLETED
Conditions: Macular Edema|Central Retinal Vein Occlusion|Hemiretinal Vein Occlusion
Interventions: DRUG: Faricimab|DRUG: Aflibercept|PROCEDURE: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DV Combined With Toripalimab for Renal Preservation in Solitary Kidney or Renal Insufficiency or Bilateral Multiple UTUC
Status: RECRUITING
Conditions: Renal Insufficiency|Upper Urinary Tract Urothelial Carcinoma|Solitary Kidney
Interventions: DRUG: DV|DRUG: Toripalimab|PROCEDURE: Laser surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Two Year of RAAS Alone or in Combination With Spironolactone Therapy
Status: RECRUITING
Conditions: Renal Insufficiency, Chronic|Diabetic Nephropathy Type 2
Interventions: DRUG: Renin-Angiotensin (RAAS) alone|DRUG: Renin-Angiotensin (RAAS) blockers in combination with Spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Standard Versus Low Dose Advagraf® With or Without Angiotensin-converting Enzyme Inhibitor (ACEi)/Angiotensin Receptor Blocker (ARB) on Histology and Function of Renal Allografts
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: tacrolimus|DRUG: tacrolimus|BIOLOGICAL: Simulect|DRUG: Cellcept|DRUG: Corticosteroids|DRUG: Ramipril|DRUG: Irbesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Trial of Immunotherapy With House Dust Mite Allergoid
Status: COMPLETED
Conditions: Rhinoconjunctivitis
Interventions: BIOLOGICAL: specific immunotherapy with Acaroid, subcutaneously, Up-titration till strength B 0.6 mL (6000 TU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Successful Transitions and Reintegration Tools for Veterans (START-VETS)
Status: RECRUITING
Conditions: Substance Use Disorder|Mental Illness|Recently Incarcerated
Interventions: BEHAVIORAL: START-VET|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Foot Muscle Strengthening in Daily Activity in Diabetic Neuropathic Patients
Status: COMPLETED
Conditions: Diabetic Neuropathies
Interventions: OTHER: Intervention Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Laser Use on Guided Tissue Regeneration in Treatment of Molar Teeth With Class 2 Furcation Affected by Periodontitis
Status: COMPLETED
Conditions: Furcation Defects|Periodontitis|Alveolar Bone Loss Beyond Furcation
Interventions: PROCEDURE: bioresorbable membrane alonewill be used for regeneration of the periodontium(control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility, Acceptability and Directional Signal Effect on Blood Folate Levels of Iodized Salt Fortified With Folic Acid: Clinical Study
Status: COMPLETED
Conditions: Neural Tube Defects|Folic Acid Deficiency|Fortification
Interventions: DIETARY_SUPPLEMENT: Salt with folic acid and iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Primary Care iSBIRT to Reduce Serious Teen Health Risks
Status: WITHDRAWN
Conditions: Substance-related Disorders|Depression|High-risk Sex
Interventions: BEHAVIORAL: iSBIRT|BEHAVIORAL: iSBIRT/TE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effects of Genistein Aglycone in Glucocorticoid Induced Osteoporosis
Status: UNKNOWN
Conditions: Osteoporosis, Steroid Induced
Interventions: DIETARY_SUPPLEMENT: Genistein aglycone|DRUG: Alendronate Oral Tablet|DIETARY_SUPPLEMENT: Calcium + vitamin D3 tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Optimizing Parameters of Low-Intensity Focused Ultrasound for Cortical Modulation in Stroke Patients
Status: RECRUITING
Conditions: Stroke
Interventions: DEVICE: Low Intensity Focused Ultrasonic Stimulation|DEVICE: Low Intensity Focused Ultrasonic Stimulation Frequency
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: MISC-IPV: A Community-Based Intervention for Children Traumatized by Intimate Partner Violence
Status: RECRUITING
Conditions: MISC Intervention|Treatment as Usual
Interventions: BEHAVIORAL: MISC intervention|BEHAVIORAL: Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Demonstrate the Relative Bioavailability of Cilostazol 50 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Cilostazol 50 mg Tablets (Eon Pharma, LLC, USA)|DRUG: Pletal (Cilostazol) 50 mg Tablets (Otsuka Pharma Co, Ltd., USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Clinical Study Between Virtual Reality Hypnosis and Nitrous Oxide Inhalation for Dental Anxie
Status: UNKNOWN
Conditions: Dental Anxiety
Interventions: DRUG: Nitrous Oxide inhalation|DEVICE: Dispositif de RV - HYPNO VR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treating Depression and Anxiety in the Cardiac Rehabilitation Pathway
Status: COMPLETED
Conditions: Depression|Anxiety|Cardiac Rehabilitation
Interventions: BEHAVIORAL: Metacognitive Therapy|BEHAVIORAL: Cardiac Rehabilitation (treatment as usual)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT