pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Elective Caesarean Section
Status: COMPLETED
Conditions: Post Partum Hemorrhage
Interventions: DRUG: Tranexamic Acid|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Opioid-Naive Population
Status: COMPLETED
Conditions: Opioid-use Disorder|Opioid Use|Opioid Abuse
Interventions: BEHAVIORAL: Choice Architecture Nudge|BEHAVIORAL: PMP Integration & Nudge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Scoliosis-specific Exercises for Mild Idiopathic Scoliosis
Status: RECRUITING
Conditions: Idiopathic Scoliosis
Interventions: OTHER: Active self-corrective exercises|OTHER: Observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Report 2 Cases of Massive Incarceration Necrosis Rectal Prolapse Are Successfully Treated With Altemeier's Procedure
Status: COMPLETED
Conditions: Rectal Prolapse
Interventions: PROCEDURE: perineal rectosigmoidectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Humoral Dysfunction in Pts With Frequent Exacerbations of COPD, and the Effect of SCIgR for Prevention
Status: RECRUITING
Conditions: COPD Exacerbation Acute
Interventions: BIOLOGICAL: CUVITRU - Ig subcutaneous human 20%|OTHER: Standard Medical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cabozantinib (XL184) in Patients With Relapsed or Refractory Myeloma
Status: COMPLETED
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: DRUG: Cabozantinib (XL184)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Imaging and Safety Study of AI-700 in Patients With Suspected Coronary Artery Disease Undergoing SPECT Imaging
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: AI-700 contrast-enhanced echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: fNIRs-based Neurofeedback to Reduce Relapse in pOUD/AUD
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use Disorder|Alcoholism|Prescription Drug Dependence|Opioid-use Disorder|Neurofeedback
Interventions: DEVICE: fNIRs-based Neurofeedback|DEVICE: Sham feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers
Status: RECRUITING
Conditions: Stage IV Esophageal Adenocarcinoma|Stage IV Esophageal Squamous Cell Carcinoma|Stage IV Gastric Cancer|Stage IV Adenocarcinoma of the Gastroesophageal Junction|Stage IVA Esophageal Adenocarcinoma|Stage IVA Esophageal Squamous Cell Carcinoma|Stage IVA Gastric Cancer|Stage IVA Adenocarcinoma of the Gastroesophageal Junction|Stage IVB Esophageal Adenocarcinoma|Stage IVB Esophageal Squamous Cell Carcinoma|Stage IVB Gastric Cancer|Stage IVB Gastroesophageal Junction Adenocarcinoma|Metastatic Anal Canal Carcinoma|Metastatic Colorectal Carcinoma|Metastatic Esophageal Carcinoma|Metastatic Gastric Carcinoma|Metastatic Gastroesophageal Junction Adenocarcinoma|Metastatic Hepatocellular Carcinoma|Metastatic Malignant Digestive System Neoplasm|Metastatic Small Intestinal Carcinoma|Pancreatobiliary Carcinoma|Pathologic Stage IV Gastric Cancer AJCC v8|Pathologic Stage IVA Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IVA Esophageal Squamous Cell Carcinoma AJCC v8|Pathologic Stage IVB Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IVB Esophageal Squamous Cell Carcinoma AJCC v8|Pathologic Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IV Esophageal Squamous Cell Carcinoma AJCC v8|Postneoadjuvant Therapy Stage IV Gastric Cancer AJCC v8|Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IVA Esophageal Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IVA Esophageal Squamous Cell Carcinoma AJCC v8|Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IVB Esophageal Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IVB Esophageal Squamous Cell Carcinoma AJCC V8|Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8|Stage IV Anal Cancer AJCC v8|Stage IV Colorectal Cancer AJCC v8|Stage IV Hepatocellular Carcinoma AJCC v8|Stage IVA Colorectal Cancer AJCC v8|Stage IVA Hepatocellular Carcinoma AJCC v8|Stage IVB Colorectal Cancer AJCC v8|Stage IVB Hepatocellular Carcinoma AJCC v8|Stage IVC Colorectal Cancer AJCC v8
Interventions: RADIATION: Radiation Therapy (RT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Guided Self-help Intervention for Improving Sleep in University Students
Status: NOT_YET_RECRUITING
Conditions: Insomnia
Interventions: BEHAVIORAL: i-Sleep & BioClock|BEHAVIORAL: Online Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Two Monthly Replacement Silicone Hydrogel Contact Lenses
Status: COMPLETED
Conditions: Myopia|Astigmatism
Interventions: DEVICE: Lotrafilcon B contact lenses|DEVICE: Comfilcon A contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Vitamin D Supplementation in Polymorphic Light Eruption
Status: TERMINATED
Conditions: Polymorphic Light Eruption
Interventions: DRUG: Oral Vitamin D 3|DRUG: Miglyol 812 N
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Exercise Training in Coronary Artery Disease Patients After Stenting
Status: COMPLETED
Conditions: Stent Restenosis|Coronary Artery Disease
Interventions: OTHER: Structured In-patient and Home plan|OTHER: Conventional Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Work of Breathing Description in Neonates With Congenital Diaphragmatic Hernia in NAVA and in Conventional Ventilation.
Status: COMPLETED
Conditions: Hernia, DIaphragmatic, Congenital
Interventions: DEVICE: Physiologic study measuring work of breathing which can be estimated by the esophageal and trans-diaphragmatic pressure-time product obtained by an esophageal transducer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: R-One Efficiency For PCI Evolution With Robotic Assistance
Status: COMPLETED
Conditions: Coronary Artery Disease|Percutaneous Coronary Intervention
Interventions: PROCEDURE: Percutaneous Coronary Intervention|DEVICE: Percutaneous Coronary Intervention using R-One assistance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hybrid PEEK-Acrylic Resin Prostheses and the All-on-4 Concept for Full-Arch Rehabilitation - Routine Group
Status: ACTIVE_NOT_RECRUITING
Conditions: Prosthesis Survival
Interventions: DEVICE: Prosthetic full-arch rehabilitation using a PEEK-acrylic resin prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mirvetuximab Soravtansine (IMG853) in Folate Receptor Alpha-expressing TNBC
Status: WITHDRAWN
Conditions: Breast Cancer Triple Negative
Interventions: DRUG: Mirvetuximab Soravtansine (IMGN853)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Sodium Oxybate on Sleep Architecture
Status: WITHDRAWN
Conditions: Mechanically Ventilated ICU Patients
Interventions: DRUG: sodium oxybate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Iron Treatment Efficiency Among Non-anemic But Iron-deficient Female Blood Donors
Status: COMPLETED
Conditions: Fatigue|Iron Deficiency
Interventions: DRUG: Ferrous sulphate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intratumoral Injection of PV-001-DV Plus DC in Patients With Melanoma
Status: NOT_YET_RECRUITING
Conditions: Advanced Melanoma
Interventions: BIOLOGICAL: Dengue Virus-1 #45AZ5 (PV-001-DV)|BIOLOGICAL: Autologous Monocyte-derived Lysate Pulsed Dendritic Cells (PV-001-DC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FCH PET/MRI Parathyroid Localization
Status: COMPLETED
Conditions: 18F-fluorocholine|Positron-Emission Tomography|Hyperparathyroidism, Primary
Interventions: DIAGNOSTIC_TEST: [F-18]-FCH PET/MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate SBRT for EGFR Mutant NSCLC Patients Receiving Osimertinib (CULTRO)
Status: NOT_YET_RECRUITING
Conditions: EGF-R Positive Non-Small Cell Lung Cancer|Non Small Cell Lung Cancer|EGFR Exon 19 Deletion|EGFR Exon 21 Mutation|EGFR G719X
Interventions: RADIATION: Stereotactic Body Radiation Therapy SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 2 Versus 6 Hour Oxaliplatin Infusions in Patients With Gastrointestinal Cancers
Status: RECRUITING
Conditions: Malignant Digestive System Neoplasm
Interventions: DRUG: Fluorouracil|DRUG: Leucovorin|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-blind, Placebo-controlled Study of RSS0393 Ointment in Healthy and Psoriatic Subjects
Status: NOT_YET_RECRUITING
Conditions: Healthy|Psoriatic Subjects
Interventions: DRUG: RSS0393 ointment；Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Model for End-Stage Liver Disease Sodium (MELD-Na) Score in Non-cirrhotic Patients With Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer|Complication,Postoperative|Complications; Gastrointestinal, Postoperative|Morality
Interventions: OTHER: MELD-Na score
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Bioequivalence Study to Compare VIMOVO Manufactured at AstraZenca AB to VIMOVO Manufactured by Patheon Pharmaceuticals and Marketed Enteric-coated Naproxen Formulation
Status: COMPLETED
Conditions: Healthy Volunteers|Bioequivalence
Interventions: DRUG: VIMOVO (AstraZeneca)|DRUG: VIMOVO (Patheon)|DRUG: Marketed enteric-coated naproxen formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PDT Plus Vitamin D3 for Anal Dysplasia
Status: WITHDRAWN
Conditions: Anal Dysplasia|Carcinoma in Situ
Interventions: DRUG: Gliolan|DRUG: Vitamin D3 cholecalciferol)|OTHER: Photodynamic Therpay
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Prehabilitation Protocol on Quality of Life After Thoracoscopic Surgery
Status: COMPLETED
Conditions: Thoracoscopy|Prehabilitation
Interventions: OTHER: Educational nursing protocol|OTHER: Routine hospital care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 3 Study of the Safety and Efficacy of OmegaD Softgels in the Treatment of Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Omega 3 fatty acid|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy of Fevipiprant in Patients With Nasal Polyposis and Asthma
Status: COMPLETED
Conditions: Nasal Polyps
Interventions: DRUG: Fevipiprant 150 mg|DRUG: Fevipiprant 450 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Compare the Effects of Tibolone (Livial®) and Continuous Combined Low-Dose Estradiol/Noresterone (Activelle®)
Status: COMPLETED
Conditions: Menopause
Interventions: DRUG: tibolone|DRUG: low-dose estradiol/noresterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Remotely Supervised Exercise Program for Lung Cancer Patients Undergoing Chemoradiation (REM)
Status: TERMINATED
Conditions: Lung Cancer
Interventions: BEHAVIORAL: Remotely Supervised Exercise (REM)|BEHAVIORAL: Unsupervised Exercise (UNSUP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Perfusion and Antihypertensive Therapy in Acute Ischemic Stroke
Status: COMPLETED
Conditions: Stroke, Acute
Interventions: DRUG: Nitroglycerin|DRUG: Labetalol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Papillomavirus (HPV) Vaccine (Cervarix TM) Efficacy, Immunogenicity & Safety Trial in Adult Japanese Women With GSK Biologicals HPV-16/18 Vaccine
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: BIOLOGICAL: HPV-16/18 vaccine (Cervarix™)|BIOLOGICAL: Aimmugen™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hyperspectral Endoscopy Imaging for the Early Detection of Precancerous Lesions in Average Risk Patients
Status: COMPLETED
Conditions: Patient
Interventions: PROCEDURE: Hyperspectral Endoscopy (HySE)|DEVICE: White Light Endoscopy (WLE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: HRS-AKI Treatment With TIPS in Patients With Cirrhosis
Status: RECRUITING
Conditions: Cirrhosis, Liver|Hepatorenal Syndrome|Acute Kidney Injury|Ascites Hepatic
Interventions: PROCEDURE: TIPS|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Evaluating Transvaginal Electrical Stimulation With a Home Use Programmable Device for Urinary Stress Incontinence
Status: UNKNOWN
Conditions: Urinary Stress Incontinence
Interventions: DEVICE: transvaginal placebo device|DEVICE: transvaginal electrical stimulation device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Durvalumab With Tremelimumab Versus SoC as 1st Line Therapy in Metastatic Non Small-Cell Lung Cancer (NSCLC) (NEPTUNE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Carcinoma NSCLC
Interventions: BIOLOGICAL: Durvalumab +Tremelimumab|DRUG: Paclitaxel + carboplatin|DRUG: Gemcitabine + cisplatin|DRUG: Gemcitabine + carboplatin|DRUG: Pemetrexed + cisplatin|DRUG: Pemetrexed + carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Budesonide in Treating Patients With Lung Nodules at High Risk of Developing Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Budesonide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Stagewise Implementation-To-Target- Medications for Addiction Treatment (SITT-MAT)
Status: ACTIVE_NOT_RECRUITING
Conditions: Addiction, Opioid
Interventions: OTHER: Enhanced Monitoring and Feedback (EMF)|OTHER: NIATx/MAT Academy|OTHER: NIATx-Internal Facilitation (NIATx-IF)|OTHER: NIATx-External Facilitation (NIATx-EF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effectiveness and Tolerability of Fitostimoline Plus vs Connettivina Bio Plus in Skin Graft
Status: UNKNOWN
Conditions: Wounds and Injuries|Skin Graft Scar|Skin Graft Complications
Interventions: DEVICE: Fitostimoline plus|DEVICE: Connettivina bio plus
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: LifE Style, Nutrition and Oral Health in Care Givers (LENTO)
Status: COMPLETED
Conditions: Nutrition Disorders in Old Age|Caries,Dental|Dentures|Oral Mucositis|Tooth Diseases|Plaque, Dental|Gingival Diseases
Interventions: OTHER: Nutrition and oral health intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Efficacy of Durvalumab Plus Tremelimumab in Combination With Chemotherapy Compared With Pembrolizumab in Combination With Chemotherapy in Metastatic Non-Small Cell Lung Cancer (NSCLC) Patients
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Durvalumab|DRUG: Tremelimumab|DRUG: Pemetrexed|DRUG: Pembrolizumab|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: European Multicentre Registry of Percutaneous Paravalvular Leak Closure
Status: RECRUITING
Conditions: Cardiac Valve Disease|Paravalvular Aortic Regurgitation|Paravalvular Mitral Regurgitation|Paravalvular Leak|Quality of Life|Outcomes
Interventions: PROCEDURE: percutaneous paravalvular leak closure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Extension, Carbidopa-levodopa in Neovascular AMD
Status: COMPLETED
Conditions: Macula; Degeneration|Retina
Interventions: DRUG: carbidopa-levodopa 25-100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Bioactive Resin Sealants vs Conventional Sealants in Permanent Molars
Status: UNKNOWN
Conditions: Caries, Dental
Interventions: COMBINATION_PRODUCT: BioCoat® by Premier®.|COMBINATION_PRODUCT: 3M™ Clinpro™ Sealant.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ophthalmologic Outcomes in Patients With Carotid Artery Stenosis
Status: RECRUITING
Conditions: Choroid Disease|Carotid Stenosis|Carotid Atherosclerosis|Retinal Disease
Interventions: DIAGNOSTIC_TEST: eye - Optcial coherence tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Real-World Evidence Study to Evaluate the Effects of Voltaren Use on Mobility and Quality of Life in Participants With Knee Osteoarthritis Pain
Status: RECRUITING
Conditions: Pain
Interventions: DRUG: Voltaren Gel 1% (diclofenac sodium) (US only)|DRUG: Voltaren Gel 1.16% (diclofenac diethylammonium) (EU only)|DRUG: Voltaren Gel 2.32% (diclofenac diethylammonium) (EU only)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carvedilol for Prevention of Paroxysmal Atrial Fibrillation
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: DRUG: Carvedilol|DRUG: Metoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Ischaemic-Reperfusion and Remote Ischaemic Preconditioning in Man - A Bradykinin Dependent Pathway
Status: COMPLETED
Conditions: Ischaemic Heart Diseases
Interventions: PROCEDURE: Forearm vascular study|DRUG: Placebo|DRUG: bradykinin receptor antagonist (HOE-140)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Proton Radiation for the Treatment of Pediatric Bone and Non-Rhabdomyosarcoma Soft Tissue Sarcomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-rhabdomyosarcoma Soft Tissue Sarcoma|Bone Sarcoma
Interventions: RADIATION: Proton Beam Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First-Time-in-Human Study to Assess the Safety and Tolerability of PP 1420 in Healthy Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: PP 1420|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Early Administration of Sodium Thiosulfate Should Help to Reduce the Mortality of Dialysis Patients With Calciphylaxis, From a National Cohort
Status: UNKNOWN
Conditions: Calciphylaxis|Renal Insufficiency, Chronic
Interventions: DRUG: Sodium Thiosulfate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Partial Double-Blind, Placebo-Controlled Study to Assess the Effect of Anastrozole on the Endometrium in Healthy Volunteers
Status: COMPLETED
Conditions: Menstruation Disorders
Interventions: DRUG: Anastrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Acute Normovolemic Hemodilution (ANH) in People With Ovarian Cancer Who Are Having Primary Cytoreductive Surgery
Status: RECRUITING
Conditions: Ovarian Cancer|Fallopian Tube Carcinoma|Ovarian Carcinoma|Peritoneal Carcinoma|Ovarian Cancer Stage IIIC|Fallopian Tube Cancer Stage IIIC|Ovarian Cancer Stage IV|Fallopian Tube Cancer Stage IV|Fallopian Tube Cancer|Peritoneal Cancer
Interventions: BIOLOGICAL: Acute Normovolemic Hemodilution/ANH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydrolized Protein Formula for Premature Infants
Status: COMPLETED
Conditions: Prematurity
Interventions: OTHER: Protein Hydrolyzed Premature Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Smart Phone Based Telemonitoring on Blood Pressure Among Hypertensive Patients in Primary Care
Status: COMPLETED
Conditions: Hypertension|Blood Pressure
Interventions: BEHAVIORAL: Smart phone telemonitoring HBP + enhanced usual care|BEHAVIORAL: Enhanced usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study Comparing IOP Lowering in OAG or OH in Japanese Subjects C-01-98
Status: COMPLETED
Conditions: Open-Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: IOP Lowering Medications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study to Allow Access to Pasireotide for Patients Benefiting From Pasireotide Treatment in Novartis-sponsored Studies
Status: COMPLETED
Conditions: Cushing's Disease|Acromegaly|Neuroendocrine Tumors|Pituitary Tumors|Ectopic ACTH Secreting (EAS) Tumors|Dumping Syndrome|Prostate Cancer|Melanoma Negative for bRAF|Melanoma Negative for nRAS
Interventions: DRUG: Pasireotide|DRUG: Cabergoline|DRUG: Pasireotide LAR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study for Evaluating the Safety of a Plant Sterol-enriched Fermented Dairy Product in Japanese Healthy Adults
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: 1-Fermented Dairy Product with Phytosterols (test)|OTHER: 2-Fermented dairy Product with No Phytosterols (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Metabolism in the Human Brain Following Consumption of a Keto-ester in Alcohol Use Disorder (AUD) With Proton Magnetic Resonance Spectroscopic Imaging (MRSI)
Status: RECRUITING
Conditions: BHB Transport|Alcohol Use Disorder
Interventions: OTHER: Keto-ester followed by Magnetic Resonance Spectroscopic Imaging (MRSI) scans
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Atezolizumab Combined With Immunogenic Chemotherapy in Patients With Metastatic Triple-negative Breast Cancer
Status: COMPLETED
Conditions: Cancer, Breast|Triple Negative Breast Cancer
Interventions: DRUG: Atezolizumab|DRUG: Pegylated liposomal doxorubicin|DRUG: Cyclophosphamide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Glutaminase Inhibitor CB-839 and Azacitidine in Treating Patients With Advanced Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Acute Myeloid Leukemia With Multilineage Dysplasia|Blasts 20-30 Percent of Bone Marrow Nucleated Cells|Blasts 20-30 Percent of Peripheral Blood White Cells|Chronic Myelomonocytic Leukemia|High Risk Myelodysplastic Syndrome|IPSS Risk Category Intermediate-2|Myelodysplastic Syndrome
Interventions: DRUG: Azacitidine|DRUG: Glutaminase Inhibitor CB-839
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnesium Pantoprazole 20mg b.i.d. vs Magnesium Pantoprazole 40mg q.d. on Intragastric Acid Inhibition
Status: WITHDRAWN
Conditions: Gastric pH Control
Interventions: DRUG: Magnesium Pantoprazole 20 mg|DRUG: Magnesium Pantoprazole 40 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protectivity and Safety of Quadrivalent Influenza HA Vaccine in Indonesian Population
Status: COMPLETED
Conditions: Safety Issues
Interventions: BIOLOGICAL: Quadrivalent Influenza Vaccine|BIOLOGICAL: Trivalent Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pacing Affects Cardiovascular Endpoints in Patients With Right Bundle-Branch Block (The PACE-RBBB Trial)
Status: TERMINATED
Conditions: Heart Failure|Right Bundle-Branch Block
Interventions: DEVICE: VVI-40|DEVICE: RV DDD-40|DEVICE: BiV DDD-40
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Evaluation of Changes in Lower Extremity Edema of Radiofrequency
Status: COMPLETED
Conditions: Idiopathic Edema
Interventions: DEVICE: radiofrequency|DEVICE: sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Imatinib Versus Dasatinib in Patients With Newly-diagnosed Chronic Phase Chronic Myeloid Leukaemia
Status: COMPLETED
Conditions: Myeloid Leukemia, Chronic, Chronic Phase
Interventions: DRUG: Imatinib|DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of DWP450 for the Treatment of Crows Feet Lines
Status: UNKNOWN
Conditions: Crows Feet Lines
Interventions: DRUG: Clostridium Botulinum A Toxin|DRUG: Clostridium Botulinum A Toxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety, Tolerability, and Pharmacokinetics of Multiple-Ascending Dose Basimglurant in Healthy Subjects and in Patients With Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: Major Depressive Disorder, Healthy Volunteer
Interventions: DRUG: Basimglurant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Lymphoma Patients Undergoing Mediastinal Radiotherapy in the Era of Modern Chemoradiation
Status: NOT_YET_RECRUITING
Conditions: Mediastinal Lymphoma|Hodgkin Lymphoma|Non Hodgkin Lymphoma
Interventions: RADIATION: Standard treatment protocol with combined chemoradiation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 3 Open-Label Extension Study of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure
Status: TERMINATED
Conditions: Symptomatic Neurogenic Orthostatic Hypotension
Interventions: DRUG: ampreloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Safety and Immunogenicity of a Candidate MAP Vaccines ChAdOx2 HAV and MVA in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Crohn Disease|Mycobacterium Avium Subspecies Paratuberculosis
Interventions: BIOLOGICAL: ChAdOx2 HAV|BIOLOGICAL: MVA HAV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Participant Agreement for Contact Tracing (PACT) Study: Enhancing Partner Notification Services.
Status: COMPLETED
Conditions: Chlamydia Infection|Contact Tracing
Interventions: BEHAVIORAL: Kit enhancement to referral|PROCEDURE: patient referral versus contract referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: Study of VIR-3434 in Healthy Volunteers and Patients With Chronic Hepatitis B Virus Infection
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: BIOLOGICAL: VIR-3434|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rehabiliation Using HUBER 360 to Reduce the Risk of Falls
Status: COMPLETED
Conditions: Rehabilitation|Exercise Therapy|Treatment Outcome|Quality of Life|Fall
Interventions: DEVICE: HUBER (LPG Systems, France)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Nurse-Led Individualized Follow-Up Intervention on Patients With Nasopharyngeal Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: BEHAVIORAL: Nurse-led intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study of GlaxoSmithKline Biologicals' Poliorix™ Vaccine
Status: COMPLETED
Conditions: Poliomyelitis|Poliomyelitis Vaccines
Interventions: BIOLOGICAL: Poliorix™|BIOLOGICAL: Oral Poliovirus vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of PRP as Therapy for Shoulder Osteoarthritis
Status: COMPLETED
Conditions: Shoulder Osteoarthritis
Interventions: PROCEDURE: Injection in the intraarticular space of glenohumeral joint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effects of Electronic Cigarettes on Vascular Health
Status: TERMINATED
Conditions: Vascular Health
Interventions: BEHAVIORAL: Electronic cigarette|BEHAVIORAL: traditional cigarette|BEHAVIORAL: (sham cigarette) - no actual exposure to cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: IMRT Combined With Erlotinib for EGFR Wild Type Non-small Cell Lung Cancer With 4-10 Brain Metastases
Status: TERMINATED
Conditions: Non-Small Cell Lung Carcinoma
Interventions: RADIATION: IMRT|RADIATION: WBRT|DRUG: erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantifying and Developing Countermeasures for the Effect of Fatigue-Related Stressors on Automation Use and Trust During Robotic Supervisory Control
Status: COMPLETED
Conditions: Sleep Deprivation
Interventions: BEHAVIORAL: Sleep deprivation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized, Double-blind, Controlled of MDMA-assisted Psychotherapy in 12 Subjects With PTSD
Status: TERMINATED
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: Placebo|DRUG: Midomafetamine|BEHAVIORAL: Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Inhaled Amikacin Solution BAY41-6551 as Adjunctive Therapy in the Treatment of Gram-Negative Pneumonia
Status: COMPLETED
Conditions: Pneumonia, Bacterial
Interventions: DRUG: Amikacin Inhalation Solution (BAY41-6551)|DRUG: Aerosolized Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Opioid-based Versus Opioid-free Endotracheal Intubation
Status: RECRUITING
Conditions: Anesthesia|Anesthesia Intubation|Opioid Use|Analgesic Non-narcotic|Fentanyl
Interventions: DRUG: ketamine-lidocaine-dexmedetomidine|DRUG: fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Ocrelizumab Treatment on Immune Cells in Lymph Nodes in Multiple Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Ocrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Combined Phacoemulsification and Diode Laser Therapy in Chronic Angle Closure Glaucoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Angle Closure Glaucoma
Interventions: PROCEDURE: phaco+MP-TSCPC|PROCEDURE: phaco+TSCPC|PROCEDURE: phaco+endocyclophotocoagulation|PROCEDURE: phaco GSL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cortical Excitability: Phenotype and Biomarker in Attention-deficit, Hyperactivity Disorder (ADHD) Therapy
Status: UNKNOWN
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: Atomoxetine|DRUG: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Revitalize Cognition: Near Infrared Stimulation in Older Adults
Status: RECRUITING
Conditions: Aging
Interventions: DEVICE: MedX 1116 Rehab Console|DEVICE: Sham MedX 1116 Rehab Console
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Perampanel as Adjunctive Treatment for Inadequately Controlled Seizures Associated With Lennox-Gastaut Syndrome
Status: TERMINATED
Conditions: Lennox-Gastaut Syndrome (LGS)
Interventions: DRUG: Placebo|DRUG: Perampanel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Rhus Coriaria L. on Serum Lipid Levels of Patients With Hyperlipidemia
Status: COMPLETED
Conditions: Hyperlipidemias
Interventions: DRUG: Rhus Coriaria L. (Rhus)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Weekly Paclitaxel, Low-Dose Estramustine, and Carboplatin in the Treatment of Hormone Refractory Prostate Carcinoma
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Paclitaxel|DRUG: Estramustine|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flexible-Dose Trial in Early Parkinson's Disease (PD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: Tavapadon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Alternative Approaches for Nausea Control
Status: COMPLETED
Conditions: Nausea
Interventions: DEVICE: Acupressure bands|OTHER: Expectancy-neutral handout|BEHAVIORAL: Expectancy-neutral MP3|OTHER: Expectancy-enhancing handout|BEHAVIORAL: Expectancy-enhancing MP3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial of Maraviroc (UK-427,857) in Combination With Zidovudine/Lamivudine Versus Efavirenz in Combination With Zidovudine/Lamivudine
Status: COMPLETED
Conditions: HIV-1
Interventions: DRUG: Maraviroc + Zidovudine/Lamivudine|DRUG: Efavirenz + Zidovudine/Lamivudine|DRUG: Maraviroc (UK-427,857) + Zidovudine/Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bazedoxifene -Treatment for Women With Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia|Schizophreniform Disorders|Schizo Affective Disorder
Interventions: DRUG: Bazedoxifene Acetate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Robotic Exoskeleton Gait Training During Acute Stroke Rehabilitation
Status: UNKNOWN
Conditions: Stroke, Acute
Interventions: DEVICE: RE (Robotic Exoskeleton)|OTHER: SOC (standard of care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of GSK679586 in Patients With Severe Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: INTRAVENOUS GSK679586|DRUG: INTRAVENOUS PLACEBO|DRUG: FLUTICASONE PROPIONATE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing a Cognitive Behavioral Model for Reducing Dyspnea in Patients With Lung Cancer
Status: COMPLETED
Conditions: Lung Non-Small Cell Carcinoma|Lung Small Cell Carcinoma
Interventions: OTHER: Best Practice|BEHAVIORAL: Cognitive Behavior Therapy|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Oral L-carnitine Supplement on Lipid Profile, Anemia, and Quality of Life of Patients
Status: COMPLETED
Conditions: Complication of Hemodialysis
Interventions: DRUG: L-carnitine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A ProspeCtive mUlticenteR Investigation on RENzar Stent Safety and Efficacy in the Treatment of Patients With Femoro-popliteal Disease in Tuscany (CURRENT Registry)
Status: RECRUITING
Conditions: Peripheral Arterial Disease
Interventions: PROCEDURE: Endovascular implantation of Renzan Stent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Tacrolimus and I.V.-Immunoglobulins in Rasmussen Encephalitis
Status: UNKNOWN
Conditions: Rasmussen Encephalitis
Interventions: DRUG: Tacrolimus|DRUG: i.v. immunoglobulins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Stretching on Visco-elastic Behaviour of the Fascia Plantaris in a Healthy Population
Status: COMPLETED
Conditions: Fasciitis, Plantar|Stretch|Rehabilitation|Stiffness of Unspecified Foot, Not Elsewhere Classified
Interventions: OTHER: Fascia stretch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Cardiac Safety of a Single Dose of AL-335 Administered on a Background of Simeprevir and Odalasvir and of Repeated Doses of Odalasvir Administered Alone in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ODV Placebo (Matching 25 mg ODV)|DRUG: ODV Placebo (Matching 200 mg ODV)|DRUG: ODV Placebo (Matching 125 mg ODV)|DRUG: ODV Placebo (Matching 100 mg ODV)|DRUG: SMV Placebo (Matching 150 mg SMV)|DRUG: AL-335 Placebo (matching 1200 mg AL-335)|DRUG: Moxifloxacin Placebo (matching 400 mg moxifloxacin)|DRUG: ODV 25 mg|DRUG: ODV 200 mg|DRUG: ODV 125 mg|DRUG: ODV 100 mg|DRUG: SMV 150 mg|DRUG: AL-335 1200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Cervical Cancer Prevention: From DNA to mRNA? - New Technologies for Cervical Cancer Screening 2
Status: UNKNOWN
Conditions: Precancerous Conditions|Neoplasms
Interventions: PROCEDURE: Experimental: immediate colposcopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Drug-drug Interaction (DDI) With a P-gp Inhibitor, Organic Anion Transporting Polypeptide OATP-inhibitor, Food Effect
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 685509 After Standardised Breakfast|DRUG: Itraconazole|DRUG: Rifampin|DRUG: BI 685509 Fasted Conditions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Duloxetine Combined With Intra-articular Injection of Corticosteroid and Hyaluronic Acid Reduces Pain in the Treatment of Knee Osteoarthritis Patients
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Chronic Pain
Interventions: DRUG: Duloxetine|DRUG: intra-articular injection of corticosteroid and hyaluronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remote Ischemic Preconditioning During Cardiopulmonary Bypass
Status: WITHDRAWN
Conditions: Lactic Acidosis
Interventions: DEVICE: Inflated cuff|DEVICE: Non inflated cuff
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Impact of Perioperative Analgesia in Prostatectomy Patients on Early Quality of Recovery (SPITALIDO)
Status: COMPLETED
Conditions: Prostatectomy|Pain
Interventions: PROCEDURE: Spinal anesthesia|DEVICE: TAP Block|OTHER: Standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Evaluating FOLFIRI + Durvalumab vs FOLFIRI + Durvalumab and Tremelimumab in Second-line Treatment of Patients With Advanced Gastric or Gastro-oesophageal Junction Adenocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric Adenocarcinoma|Gastric Cancer
Interventions: DRUG: Durvalumab|DRUG: Tremelimumab|DRUG: FOLFIRI Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Iodine-131 Anti-B1 Antibody for Patients With Non Hodgkin's Lymphoma Who Have Previously Received Rituximab
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin
Interventions: BIOLOGICAL: Anti-B1 Antibody and Iodine-131 Anti-B1 Antibody (Tositumomab and Iodine I 131 Tositumomab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT