pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of High-intensity Exercise Training on Physical Fitness, Cognition, Language in Post-stroke Aphasia
Status: ACTIVE_NOT_RECRUITING
Conditions: Aphasia, Acquired|Aphasia|Aphasia, Fluent|Aphasia Non Fluent
Interventions: BEHAVIORAL: Low-intensity physical exercise|BEHAVIORAL: High-intensity physical exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Organ Preservation in Rectal Cancer: Contact X-ray Brachytherapy vs Extending the Waiting Interval and Local Excision
Status: RECRUITING
Conditions: Organ Preservation|Rectal Cancer|Quality of Life|Locally Advanced Rectal Carcinoma
Interventions: RADIATION: Contact x-ray brachytherapy|PROCEDURE: Local excision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aspirin or Rivaroxaban Thromboprophylaxis for Patients With Multiple Myeloma
Status: NOT_YET_RECRUITING
Conditions: Multiple Myeloma|Venous Thromboembolism
Interventions: DRUG: Aspirin 100mg|DRUG: Rivaroxaban 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Stress Reactivity in Veterans Receiving Pharmacological Treatment for PTSD and Alcohol Dependence
Status: COMPLETED
Conditions: Post-traumatic Stress Disorder|Alcohol Dependence
Interventions: BEHAVIORAL: stress
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy, Safety and Tolerability of Balcinrenone/Dapagliflozin Compared to Dapagliflozin in Adults With Chronic Kidney Disease
Status: RECRUITING
Conditions: Chronic Kidney Disease
Interventions: DRUG: Balcinrenone/dapagliflozin 15 mg/10 mg and matching placebo for dapagliflozin 10 mg|DRUG: Balcinrenone/dapagliflozin 40 mg/10 mg and matching placebo for dapagliflozin 10 mg|DRUG: Dapagliflozin 10 mg and matching placebo for balcinrenone/dapa gliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Finding Study of BKM 120 in Combination With LH-RH Agonists and Bicalutamide in Men With Non Castrate Metastatic Prostate Cancer
Status: TERMINATED
Conditions: Non Castrate Metastatic Prostate Cancer
Interventions: DRUG: BKM120 in combination with LH-RH agonists (suprefact) and bicalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Stainless Steel and Bioabsorbable Screw Fixation of Lisfranc Foot Injuries
Status: COMPLETED
Conditions: Unstable Lisfranc Fracture-dislocations of the Midfoot
Interventions: PROCEDURE: Steel screw fixation of Lisfranc fracture-dislocation.|PROCEDURE: Absorbable screw fixation of Lisfranc fracture-dislocations.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ginkgo Biloba Extract in the Treatment of Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Ginkgo Biloba Extract|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Combination of Ribociclib Plus Goserelin Acetate With Hormonal Therapy Versus Combination Chemotherapy in Premenopausal or Perimenopausal Patients With Advanced or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: COMBINATION_PRODUCT: Docetaxel / Capecitabine|COMBINATION_PRODUCT: Capecitabine / Vinorelbine|COMBINATION_PRODUCT: Paclitaxel / Gemcitabine|DRUG: Ribociclib|DRUG: Letrozole OR Anastrozole|DRUG: Goserelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Dynamic Versus Static Lag Screw Modes for Cephalomedullary Nails Used to Fix Intertrochanteric Fragility Fractures
Status: UNKNOWN
Conditions: Hip Fractures
Interventions: DEVICE: Osteosynthesis with Gamma 3 nail , using a dynamic lag screw as a proximal fixation.|DEVICE: Osteosynthesis with Gamma 3 nail , using a static lag screw as a proximal fixation.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crushed Ticagrelor Versus Eptifibatide Bolus + Clopidogrel
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Angina, Unstable
Interventions: DRUG: Ticagrelor|DRUG: Eptifibatide|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pretreatment With Valproate Prior to Immunotherapy Targeting Cluster of Differentiation Antigen 20 in Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Valproate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 14 Week, Randomized, Placebo-Controlled Cross-Over Study of Methylphenidate Hydrochloride Controlled Release Capsules in Adult ADHD With and Without Anxiety Disorder Comorbidity
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder|Generalized Anxiety Disorder|Social Anxiety Disorder|Panic Disorder|Agoraphobia
Interventions: DRUG: Methylphenidate Hydrochloride Controlled-Release Capsules|DRUG: Placebo Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Value of Platelet-Rich Plasma in Chronic Midportion Achilles Tendinopathy: a Double-blind Randomized Clinical Trial
Status: COMPLETED
Conditions: Achilles Tendinopathy
Interventions: BIOLOGICAL: PRP Injection with eccentric exercises|BIOLOGICAL: Placebo Injection with eccentric exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamics, Pharmacokinetics, Safety and Tolerability of PTH Analog Tablets in Postmenopausal Women
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis
Interventions: DRUG: PTH analog|DRUG: Placebo|DRUG: Forsteo (Teriparatide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Three Formulations of Ibuprofen in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteer Study
Interventions: DRUG: REFERENCE 1: Nurofen® 200 mg tablet|DRUG: REFERENCE 2: Ibuprofen 200 mg soft gel capsule|DRUG: ibuprofen 200 mg soft gel capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Citicoline for Bipolar 1 Disorder and Cocaine Dependence
Status: COMPLETED
Conditions: Bipolar Disorder|Cocaine Dependence
Interventions: DRUG: Citicoline|DRUG: Placebo|BEHAVIORAL: Cognitive Behavioral Therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Dose Escalation Study of E7107 Administered IV (Bolus) on Days 1, 8, and 15 Every 28 Days to Patients With Solid Tumours
Status: SUSPENDED
Conditions: Cancer
Interventions: DRUG: E7107
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy, Surgery, and Chemotherapy in Treating Patients With Rectal Cancer That Can Be Surgically Removed
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: fluorouracil|DRUG: leucovorin calcium|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: CBT-I for Psychosis: Guidelines, Preliminary Efficacy, and Functional Outcomes
Status: COMPLETED
Conditions: Insomnia|Psychosis
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy-Insomnia|BEHAVIORAL: Health and Wellness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Inavolisib|DRUG: Bevacizumab|DRUG: Cetuximab|DRUG: Atezolizumab|DRUG: Tiragolumab|DRUG: SY-5609|DRUG: Divarasib|DRUG: FOLFOX|DRUG: FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cortical Excitability in Patients With Severe Brain Injury
Status: UNKNOWN
Conditions: Severe Traumatic Brain Injury|Subarachnoid Hemorrhage|Anoxic Brain Injury
Interventions: DEVICE: Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ethyl Icosapentate and Physical Activity in Treating Fatigue in Patients With Advanced Cancer
Status: TERMINATED
Conditions: Advanced Malignant Neoplasm|Fatigue
Interventions: DRUG: Ethyl Icosapentate|BEHAVIORAL: Exercise Intervention|BEHAVIORAL: Exercise Intervention|OTHER: Laboratory Biomarker Analysis|OTHER: Placebo|BEHAVIORAL: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effectiveness of Ultrasound Guided Ozone (O2-O3) Injection With Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Medical ozone injection|PROCEDURE: steroid injection group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Interactions of Losartan and Hydrochlorothiazide
Status: COMPLETED
Conditions: Healthy Normotensive Participants
Interventions: DRUG: Losartan/hydrochlorothiazide|DRUG: Losartan|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Monoclonal Antibody A1G4 Plus BCG in Treating Patients With Cancer
Status: COMPLETED
Conditions: Neuroblastoma|Sarcoma
Interventions: BIOLOGICAL: BCG vaccine|BIOLOGICAL: monoclonal antibody A1G4 anti-idiotype vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Apligraf in Nonhealing Wounds of Subjects With Junctional or Dystrophic Epidermolysis Bullosa (EB)
Status: TERMINATED
Conditions: Epidermolysis Bullosa, Junctional|Epidermolysis Bullosa Dystrophica
Interventions: DEVICE: Apligraf|OTHER: Standard dressing regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: DRUG: asparaginase|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: dexamethasone|DRUG: etoposide|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: prednisolone|DRUG: thioguanine|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of SHR-2004 Injection in Preventing Postoperative Venous Thromboembolism in Patients Undergoing Ovarian Cancer Surgery
Status: NOT_YET_RECRUITING
Conditions: Preventing Postoperative Venous Thromboembolism in Patients Undergoing Ovarian Cancer Surgery
Interventions: DRUG: SHR-2004|DRUG: Enoxaparin Sodium Injection; Rivaroxaban Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dose-seeking Study of Pembrolizumab Plus Vemurafenib and Cobimetinib Advanced Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: Pembrolizumab|DRUG: Vemurafenib|DRUG: Cobimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study for Training Pump Naïve Subjects To Use The Paradigm® System And Evaluate Effectiveness
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: MiniMed Paradigm REAL-Time System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Comparing Continuous Versus Intermittent Hemodialysis in ICU Patients
Status: COMPLETED
Conditions: Acute Renal Failure
Interventions: OTHER: RRT for acute kidney failure using the CVVH method|OTHER: RRT for acute kidney failure using the IHD (intermittent HD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Azithromycin for Child Survival in Niger: Programmatic Trial (AVENIR)
Status: RECRUITING
Conditions: Resistance Bacterial|Morality|Child Health|Implementation
Interventions: DRUG: Azithromycin for Oral Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesia After Video-Assisted Thoracic Surgery
Status: UNKNOWN
Conditions: Post Operative Pain
Interventions: DRUG: Ultrasound-guided deep serratus anterior plane block with isobaric bupivacaine|DRUG: Local wound infiltration with isobaric bupivacaine|DRUG: Ultrasound-guided thoracic paravertebral block with isobaric bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: FLU-VACS Comparative Study in Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Cold-adapted live attenuated influenza virus vaccine, trivalent|OTHER: Placebo|BIOLOGICAL: Trivalent inactivated influenza vaccine|BIOLOGICAL: Trivalent inactivated influenza vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Regorafenib in Combination With Pembrolizumab or Pembrolizumab for MSI-H Colorectal Cancer
Status: RECRUITING
Conditions: MSI-H Colorectal Cancer
Interventions: DRUG: Regorafenib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibuprofen Versus Ketorolac by Mouth in the Treatment of Acute Pain From Osteoarticular Trauma
Status: COMPLETED
Conditions: Acute Pain Due to Trauma
Interventions: DRUG: Ketorolac|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of the Vaccine ALVAC-HIV vCP205 in HIV-Negative Adult Volunteers in Uganda
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: ALVAC-HIV MN120TMG (vCP205)|BIOLOGICAL: ALVAC-RG Rabies Glycoprotein (vCP65)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Investigation of Linaclotide's Effect on the Bi-directional Brain and Gut Axis in IBS-C Patients
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Constipation (IBS-C)
Interventions: DRUG: Linaclotide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Phase 1/2 Trial of SP-101 for the Treatment of Cystic Fibrosis (CF)
Status: RECRUITING
Conditions: Cystic Fibrosis
Interventions: COMBINATION_PRODUCT: SP-101 and doxorubicin Cohort 1|COMBINATION_PRODUCT: SP-101 and doxorubicin Cohort 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiac Neuromodulation Therapy (CNT) "Washout" Sub-Study
Status: RECRUITING
Conditions: Hypertension,Essential|Systolic Hypertension
Interventions: DEVICE: Programmable Hypertension Control (BackBeat Moderato)|DEVICE: Pacing (BackBeat Moderato)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy Study of Cells Sheet-Autologous Chondrocyte Implantation to Treat Articular Cartilage Defects
Status: UNKNOWN
Conditions: Osteochondritis|Osteochondritis Dissecans|Joint Diseases
Interventions: DRUG: CS-ACI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiac Remodeling and Prognosis in Secondar Tricuspid Regurgitation
Status: COMPLETED
Conditions: Remodeling, Cardiac|Tricuspid Regurgitation
Interventions: OTHER: Moderate to severe tricuspid regurgitation (≥ 2/4) diagnosed with echocardiography in patients stabilized.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Tipranavir/Ritonavir on the Pharmacokinetic Characteristics of Triple Drug Nucleoside and Non-nucleoside Reverse Transcriptase Inhibitor Therapy in HIV-1-infected Subjects
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Tipranavir low dose|DRUG: Tipranavir medium dose|DRUG: Tipranavir high dose|DRUG: Ritonavir low dose|DRUG: Ritonavir high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Neonatal Acid-Base Status After C Section With Maternal Tilt vs. Supine
Status: COMPLETED
Conditions: Aortocaval Compression|Fetal Acidosis
Interventions: PROCEDURE: SUPINE|PROCEDURE: TILT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of MBI 226 2.5% and 5.0% Topical Acne Solutions in the Treatment of Acne
Status: COMPLETED
Conditions: Acne Vulgaris|Acne|Propionibacterium Acnes
Interventions: DRUG: MBI 226 Acne Solutions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Harvest of Free Gingival Grafts With or Without the Application of Hemostatic Sutures
Status: COMPLETED
Conditions: Thin-gingiva|Mucogingival Deformity on Edentulous Ridge|Gingival Recession
Interventions: PROCEDURE: Simplified suture-less approach|PROCEDURE: Application of hemostatic sponges and compressive sutures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy, Safety, and Tolerability of Intravenous Ganaxolone Added to Standard of Care in Refractory Status Epilepticus (RSE)
Status: WITHDRAWN
Conditions: Refractory Status Epilepticus
Interventions: DRUG: Ganaxolone|DRUG: Placebo|DRUG: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study to Evaluate the Pharmacokinetics of JDQ443 in Participants With Hepatic Impairment Compared to Matched Healthy Control Participants.
Status: RECRUITING
Conditions: Small Cell Lung Carcinoma
Interventions: DRUG: JDQ443
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Hydroxychloroquine on Atrial Fibrillation Recurrence
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DRUG: Hydroxychloroquine Sulfate 200 Mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cisplatin-Pemetrexed Compared With Carboplatin-Paclitaxel-Bevacizumab in KRAS Mutated Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Carcinoma, Non-Small Cell Lung
Interventions: DRUG: carboplatin|DRUG: paclitaxel|DRUG: Bevacizumab|DRUG: Pemetrexed|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: P-Gemox Regimen as First-line Chemotherapy in NK/T Lymphoma Patiens
Status: TERMINATED
Conditions: Lymphoma, Extranodal NK-T-Cell
Interventions: DRUG: gemcitabine|DRUG: oxaliplatin|DRUG: pegaspargase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effects of Itraconazole, Food, and pH on the Drug Levels of BMS-986368 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: BMS-986368|DRUG: Itraconazole|DRUG: Famotidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of a Platform Wound Device for Reducing Infection
Status: COMPLETED
Conditions: Wounds and Injury|Burn Wound|Infection Wound
Interventions: COMBINATION_PRODUCT: Gentamycin with Platform Wound Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-38431055 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: JNJ-38431055
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Lipid Metabolism in COVID-19 Severe Pneumonia Compared With Severe Pneumonia Caused by Other Pathogen
Status: COMPLETED
Conditions: COVID-19 Severe Pneumonia|Severe Pneumonia Due to Other Pathogene
Interventions: BIOLOGICAL: biological assays in particular on the lipid metabolism
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Imaging-based Assessment of Oral Biofilm and Gingival Health
Status: RECRUITING
Conditions: Plaque, Dental|Gingivitis
Interventions: OTHER: OTC Toothpastes or Mouthrinses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Armatinib Alone or in Combination With SRT for Brain Metastases EGFR-mutated Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer Metastatic
Interventions: DRUG: Almonertinib|RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD
Status: COMPLETED
Conditions: Metabolic Acidosis|Chronic Kidney Disease|Cognitive Dysfunction
Interventions: DRUG: Sodium Bicarbonate Tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Exercise Training on Muscle Mass in Patients With Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Knee Osteoarthritis|Arthropathy of Knee Joint
Interventions: OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Ulcerative Colitis With Rectal Instillation of Qinghua Quyu Prescription(QHQYP)
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: Treatment group: Rectal instillation of QHQYP|DRUG: Control group: Mesalazine enema treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study for Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: LY2140023|DRUG: LY2140023|DRUG: LY2140023|DRUG: LY2140023|DRUG: Olanzapine|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Maintenance ADAPT Therapy With Capecitabine and Celecoxib in Patients With Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Recurrent Colon Carcinoma|Recurrent Rectal Carcinoma|Stage IVA Colon Cancer|Stage IVA Rectal Cancer|Stage IVB Colon Cancer|Stage IVB Rectal Cancer
Interventions: DRUG: Capecitabine|DRUG: Celecoxib|RADIATION: Intensity-Modulated Radiation Therapy|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment|RADIATION: Radiation Therapy|RADIATION: Stereotactic Radiosurgery|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Acceptability of Offering Self-sampling to Non-attendees in Primary Care
Status: COMPLETED
Conditions: Cancer of the Uterine Cervix
Interventions: DEVICE: Cobas HPV DNA Test|OTHER: Papanicolau test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Nutrigenetic Intervention on Blood Lipid Markers and Body Composition of Adults With Overweight and Obesity
Status: COMPLETED
Conditions: Dyslipidemias|Overweight and Obesity
Interventions: OTHER: NUTRIGENETIC DIET INTERVENTION|OTHER: CONVENTIONAL DIET INTERVENTION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Tolerability, Safety, and Pharmacokinetics of ZL-82 in Healthy Adult Subjects.
Status: RECRUITING
Conditions: Rheumatoid Arthritis (RA)|Inflammatory Bowel Disease - IBD1
Interventions: DRUG: ZL-82 12.5mg|DRUG: ZL-82 25mg|DRUG: ZL-82 50mg|DRUG: ZL-82 100mg|DRUG: ZL-82 200mg|DRUG: ZL-82 300mg|DRUG: ZL-82 450mg|DRUG: ZL-82 600mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Health Education Delivery Methods for a Low Fermentable Carbohydrate Diet in Patients With Functional Bowel Disorders
Status: COMPLETED
Conditions: Irritable Bowel Syndrome|Functional Diarrhea|Functional Bowel Disorder
Interventions: OTHER: Health education delivery methods
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Use PUL-042 to Reduce the Infection Rate and Progression to COVID-19 in Adults Exposed to SARS-CoV-2
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: PUL-042 Inhalation Solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Melatonin on Depression, Anxiety, Cognitive Function and Sleep Disturbances in Breast Cancer Patients
Status: TERMINATED
Conditions: Breast Cancer|Depression
Interventions: DRUG: Melatonin (N-acetyl-5-methoxytryptamine)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ropivacaine Use Intraincisionally Versus Intraperitoneally for Post-Laparoscopic Cholecystectomy Pain
Status: COMPLETED
Conditions: Ropivacaine|Laparoscopic Cholecystectomy|Pain
Interventions: DRUG: 0.2% ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Developing Cognitive Training for Tourette Syndrome
Status: COMPLETED
Conditions: Tourette Syndrome|Chronic Tic Disorders
Interventions: BEHAVIORAL: Comprehensive Behavioral Intervention for Tics (CBIT)|BEHAVIORAL: Computerized Response Inhibition Training|BEHAVIORAL: Computerized Placebo Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postprandial Lipidemia After a Meal With Different Types of Fat, Estrogen Treatment, Age and Gender in Healthy Subjects
Status: UNKNOWN
Conditions: Menopause
Interventions: DRUG: Estrogens|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Nebulised Beclomethasone Dipropionate Plus as Needed Salbutamol vs as Needed Salbutamol or as Needed Salbutamol/Beclomethasone Fixed Combination in Young Children With Asthma Symptoms
Status: COMPLETED
Conditions: Bronchial Asthma
Interventions: DRUG: Beclomethasone dipropionate|DRUG: Beclomethasone dipropionate/Salbutamol combination|DRUG: Salbutamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Alpha Lipoic Acid as an Adjuvant Treatment in Acute Phosphide Poisoning
Status: UNKNOWN
Conditions: Toxicity
Interventions: DRUG: Alpha Lipoic Acid (Thioctacid)|DRUG: Placebo (for Alpha Lipoic Acid)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Reinforcement of Oral Hygiene Education Through Video During Fixed Orthodontic Treatment in Adults
Status: RECRUITING
Conditions: Oral Hygiene Reinforcement During Fixed Orthodontic Treatment
Interventions: BEHAVIORAL: On-site video group|BEHAVIORAL: Remote video group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Vision Effects of a Cosmetic Tinted Hydrogel Contact Lens
Status: COMPLETED
Conditions: Refractive Error
Interventions: DEVICE: Hioxifilcon A Test|DEVICE: Hioxifilcon A With Cosmetic Ring Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effect to Postoperative Pain After Mastectomy: Ultrasound-guided Serratus Anterior Plane Block
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Ultrasound guided serratus anterior block with ropivacaine|DRUG: intravenous PCA only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pyrotinib in Combination With Trastuzumab and Docetaxel in Patients With HER2 Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Pyrotinib, Trastuzumab, Docetaxel|DRUG: Placebo, Trastuzumab, Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of INCB054707 in Participants With Normal and Impaired Renal Function and Participants on Hemodialysis
Status: COMPLETED
Conditions: Renal Insufficiency|Kidney Diseases
Interventions: DRUG: INCB054707
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HCC Response Assessment by MRI After SBRT
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: RADIATION: SBRT delivers high dose selective irradiation with millimeter precision to a small volume. The Cyberknife® is a robotic SBRT dedicated device that can deliver 100 to 200 photobeams to the target
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Sulindac, Aspirin, and Ursodiol in Preventing Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: Acetylsalicylic acid (Aspirin)|DRUG: Sulindac|DRUG: Ursodiol|OTHER: Sulindac Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Sugammadex and Sugammadex-neostigmine Combination in the Antagonism of Moderate Neuromuscular Block
Status: UNKNOWN
Conditions: Residual Neuromuscular Block|Neuromuscular Blockade Monitoring
Interventions: DIAGNOSTIC_TEST: Neuromuscular monitoring|OTHER: reverse of NMB with sugammadex|OTHER: reverse of NMB with Sugammadex and neostigmin low dose|OTHER: reverse of NMB with Sugammadex and neostigmin high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Efficacy of Ketorolac 0.4% in Prostaglandin Suppression
Status: COMPLETED
Conditions: Inflammation
Interventions: DRUG: Ketorolac 0.4%|DRUG: Lubricating Eye Drop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase I Study to Assess PSMA+ and PSMA- Tumour Lesions
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced and/or Metastatic Solid Tumours
Interventions: DRUG: Radiolabelled CB307|DRUG: CB307
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk-stratification Based Bladder-sparing Modalities for Muscle-invasive Bladder Cancer
Status: RECRUITING
Conditions: Bladder Cancer
Interventions: DRUG: Tislelizumab|DRUG: gemcitabine and cisplatin|RADIATION: Modified hypofractionation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of ON101 Cream for the Treatment of Chronic Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot
Interventions: DRUG: ON101 Cream|OTHER: Aquacel® Hydrofiber® dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Factorial Trial of Ultrasound and Manometry to Improve the Success of Thoracic Epidural Placement
Status: UNKNOWN
Conditions: Surgery
Interventions: PROCEDURE: Ultrasound Only|PROCEDURE: Manometry Only|PROCEDURE: Ultrasound Plus Manometry|PROCEDURE: Usual Care/Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate DACC Dressings for the Prevention of Surgical Site Infections in Women Undergoing Caesarean Section.
Status: COMPLETED
Conditions: Surgical Site Infection|Infection; Cesarean Section
Interventions: DEVICE: DACC impregnated dressing|DEVICE: Standard surgical dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Bispecific Antibody in Finding Tumor Cells in Patients With Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: OTHER: enzyme-linked immunosorbent assay|OTHER: pharmacological study|PROCEDURE: whole-body scintigraphy|RADIATION: iodine I 131-labeled anti-CEA/anti-HSG bispecific monoclonal antibody TF2
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Bioequivalence Study of Tobramycin and Prednisolone Acetate Compared to PredForte
Status: COMPLETED
Conditions: Eye Infections|Postoperative Complications
Interventions: DRUG: Prednisolone and Tobramycin|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized Nutrition Advice for Optimizing Dietary Calcium Intake in MS Patients
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: PROCEDURE: Individual dietary consultations|PROCEDURE: Dietary advice sheet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ventilation of the Extremely Premature Infants Optimized by Dead Space Washout
Status: NOT_YET_RECRUITING
Conditions: Extremely Low Birthweight Infant|Continuous Tracheal Gas Insufflation|Medical Device|Lung Protection|Ventilator-Induced Lung Injury
Interventions: DEVICE: ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Assess the Safety and Efficacy of Intravenous Administration of Allogeneic Adult Mesenchymal Stem Cells of Expanded Adipose Tissue in Patients With Severe Pneumonia Due to COVID-19
Status: COMPLETED
Conditions: Sars-CoV2
Interventions: DRUG: ALLOGENEIC AND EXPANDED ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELLS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega Tots Long Term Follow-up
Status: ENROLLING_BY_INVITATION
Conditions: Preterm Birth|Child Development
Interventions: DRUG: Docosahexaenoic Acid + Arachidonic Acid (DHA+AA)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy Plus Doxorubicin in Treating Patients With Resectable Primary or Recurrent Retroperitoneal Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Sarcoma
Interventions: DRUG: Doxorubicin hydrochloride (DOX)|PROCEDURE: Conventional surgery|RADIATION: Intraoperative radiation therapy (IORT)|RADIATION: Radiation Therapy (RT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus (Sle)
Interventions: DIETARY_SUPPLEMENT: Nicotinamide Riboside
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Application of Donor-derived TCM After Allogeneic HSCT
Status: COMPLETED
Conditions: Leukemia, Myeloid, Acute|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: TCM allogeneic humane central memory T cells, cryopreserved
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Label Demonstration Project and Phase II Safety Study of Pre-Exposure Prophylaxis
Status: COMPLETED
Conditions: HIV Infection
Interventions: BEHAVIORAL: 3MV|BEHAVIORAL: PCC|DRUG: Emtricitabine/tenofovir (FTC/TDF (Truvada®))
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Implementation of a Personalised Health Plan (PHP) on Patient Quality of Life Score at 2-year Follow-up
Status: NOT_YET_RECRUITING
Conditions: Elderly, Frail
Interventions: DIAGNOSTIC_TEST: Quality of life test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: VIdeo Telehealth in ALzheimer's: NeuroPsychology (VITAL-NP)
Status: COMPLETED
Conditions: Suspected Typical Alzheimer's Disease (AD)|Suspected Atypical Alzheimer's Disease (AD)
Interventions: BEHAVIORAL: Face-to-face evaluation (FF)|BEHAVIORAL: TeleNP evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: AntiPhospholipid Syndrome Low-molecular-weight Heparin Pregnancy Loss Evaluation: The Pilot Study
Status: TERMINATED
Conditions: Antiphospholipid Syndrome in Pregnancy|Pregnancy Loss
Interventions: DRUG: Aspirin 81 mg|DRUG: Low-molecular-weight heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endometrioma Treatment and Ovarian Function
Status: UNKNOWN
Conditions: Endometrioma
Interventions: PROCEDURE: Laparoscopic argon plasma treatment of endometrioma|PROCEDURE: Laparoscopic stripping of endometrioma and suture/coagulation of the rest of ovary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COVIDNOCHE Trial (HFNO Versus CPAP Helmet) in COVID-19 Pneumonia
Status: WITHDRAWN
Conditions: Severe Acute Respiratory Syndrome Coronavirus 2|Hypoxemic Respiratory Failure|Pneumonia, Viral|COVID
Interventions: DEVICE: Helmet Continuous Positive Airway Pressure (CPAP)|DEVICE: High Flow Nasal Oxygen (HFNO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Clinical Equivalence Between Two Lubiprostone Products
Status: COMPLETED
Conditions: Chronic Idiopathic Constipation
Interventions: DRUG: Lubiprostone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of the FIL on Elderly Frail Patients With DLBCL
Status: COMPLETED
Conditions: Diffuse Large B-cells Non-Hodgkin Lymphoma
Interventions: DRUG: Rituximab-Dexamethasone-Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of High Intensity Statin Therapy on Steroid Hormones and Vitamin D in Type 2 Diabetic Men
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Dyslipidemia Associated With Type II Diabetes Mellitus|Statin Adverse Reaction|Hypogonadism, Male|Adrenal Insufficiency|Vitamin D Deficiency
Interventions: DRUG: Atorvastatin 40 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Anlotinib in the Maintenance Treatment of Non-Squamous Non-Small Cell Lung Cancer.
Status: UNKNOWN
Conditions: Non-squamous Non-small-cell Lung Cancer
Interventions: DRUG: Anlotinib + Pemetrexed+Carboplatin|DRUG: Pemetrexed|DRUG: Anlotinib + Pemetrexed|DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing AZD5363 as a Potential Targeted Treatment in Cancers With AKT Genetic Changes (MATCH-Subprotocol Y)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lymphoma|Advanced Malignant Solid Neoplasm|Hematopoietic and Lymphoid Cell Neoplasm|Refractory Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Multiple Myeloma
Interventions: DRUG: Capivasertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Ventilador Innovation Product in Colombia in the SARS COVID 19 Pandemic, Unisabana Herons.
Status: COMPLETED
Conditions: Covid19
Interventions: DEVICE: Invasive mechanical ventilation using the Unisabana-Herons Ventilator during 24 hours
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Multi-center, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Certolizumab Pegol in Combination With Methotrexate in the Treatment of Disease Modifying Antirheumatic Drugs (DMARD)-naïve Adults With Early Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Certolizumab Pegol + Methotrexate (MTX)|BIOLOGICAL: Placebo + Methotrexate (MTX)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of ASC42 Tablets in Subjects With Primary Biliary Cholangitis
Status: COMPLETED
Conditions: Primary Biliary Cholangitis
Interventions: DRUG: ASC42 5 mg|DRUG: ASC42 10 mg|DRUG: ASC42 15 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trabeculectomy Versus 2-iStent and Prostaglandin Study
Status: WITHDRAWN
Conditions: Glaucoma, Open-Angle
Interventions: DEVICE: iStent and travoprost or latanoprost|PROCEDURE: Trabeculectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dehydration of Stenfilcon A Contact Lenses Versus Delefilcon A Contact Lenses
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: stenfilcon A|DEVICE: delefilcon A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT