pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Minimally Invasive Volume Augmentation of Papillae Around Implant Restorations With Hyaluronic Acid Injection
Status: COMPLETED
Conditions: Interdental Papilla Augmentation
Interventions: DRUG: Hyaluronan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Systemic Effects After Local Injection of Platelet-rich Plasma
Status: COMPLETED
Conditions: Platelet Rich Plasma (PRP)
Interventions: OTHER: platelet rich plasma|OTHER: saline injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ASK120067 Versus Gefitinib as First-line Treatment for EGFRm Locally Advanced or Metastatic NSCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced or Metastatic NSCLC
Interventions: DRUG: ASK120067|DRUG: Placebo Gefitinib 250 mg|DRUG: Gefitinib|DRUG: Placebo ASK120067
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Assessment of Atomoxetine With MA IV Administration
Status: TERMINATED
Conditions: Methamphetamine Abuse|Methamphetamine Dependence
Interventions: DRUG: Atomoxetine, then Placebo|DRUG: Placebo, then Atomoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Between Ciprofol and Mefanamic Acid or Valproate
Status: COMPLETED
Conditions: Drug Drug Interaction
Interventions: DRUG: Mefanamic Acid|DRUG: Valproate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Bispectral Index Monitoring (BIS) on Body Movement of Outpatients Undergoing Gastroscopy
Status: COMPLETED
Conditions: Gastroscopy
Interventions: OTHER: Bispectral index|OTHER: Observer's assessment alert Sedation|PROCEDURE: Gastroscopy|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Simulation-based Training on Transoesophageal Echocardiography Learning
Status: COMPLETED
Conditions: Knowledge, Attitudes, Practice|Cardiovascular Diseases|Valvular Heart Disease
Interventions: DIAGNOSTIC_TEST: TEE simulation-based training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Somatic Acupressure for Symptom Cluster Management in Breast Cancer Survivors
Status: RECRUITING
Conditions: Breast Neoplasm Female|Symptom Cluster
Interventions: OTHER: True acupressure|OTHER: Sham acupressure|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Recovery Kinetics After the Use of Small Sided Games With a Small and Large Number of Players and Large Pitch Area
Status: UNKNOWN
Conditions: Sided Games in Soccer Training
Interventions: OTHER: Small Number of Players training protocol A|OTHER: Large Number of Players training protocol B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Lapatinib and Epirubicin in Treating Patients With Metastatic Breast Cancer. ICORG 06-30
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: epirubicin hydrochloride|DRUG: lapatinib ditosylate|OTHER: biomarker analysis|OTHER: immunohistochemistry staining method|OTHER: liquid chromatography|OTHER: mass spectrometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Cabazitaxel-XRP6258 in Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer (NSCLC)|Stage IV NSCLC|Metastatic NSCLC
Interventions: DRUG: Cabazitaxel-XRP6258 (3-week cycle)|DRUG: Cabazitaxel-XRP6258 (5-week cycle)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Demonstrate the Effectiveness to Hemopatch in Controlling Postoperative Bleeding After Laparoscopic Cholecistectomy and in Reducing of Morbidity and Postoperative Hospital Stay
Status: UNKNOWN
Conditions: Efficacy of Hemopatch in Controlling of Postoperative Bleeding or Reducing of Postperative Morbidity After Laparoscopic Cholecistectomy
Interventions: OTHER: Hemopatch Sealing Hemostat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mobile Device Outcomes-based Rehabilitation Program
Status: UNKNOWN
Conditions: Transfemoral Amputation|Transtibial Amputation
Interventions: DEVICE: Rehabilitative Lower-limb Orthopedic Accommodating-feedback Device (ReLOAD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Stabilization Exercises and Posture Training on Breast Feeding Females Suffering From Scapular Dyskinesia
Status: COMPLETED
Conditions: Scapular Dyskinesis
Interventions: OTHER: Stabilization Exercises|OTHER: Posture Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ascorbic Acid and Combination Chemotherapy in Treating Patients With Locally Advanced or Recurrent Pancreatic Cancer That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma|Recurrent Pancreatic Carcinoma|Stage III Pancreatic Cancer|Stage IV Pancreatic Cancer|Unresectable Pancreatic Carcinoma
Interventions: DRUG: Oxaliplatin|DRUG: Irinotecan Hydrochloride|DRUG: Leucovorin Calcium|DRUG: Fluorouracil|DIETARY_SUPPLEMENT: Ascorbic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Dose of Bupivacaine in Combined Spinal Epidurals To Reduce Side Effects
Status: COMPLETED
Conditions: Pregnancy
Interventions: DRUG: Bupivacaine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Vicriviroc (MK-7690) in Combination With Pembrolizumab (MK-3475) in Participants With Advanced/Metastatic Microsatellite Stable (MSS) Colorectal Cancer (CRC) (MK-7690-046)
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: DRUG: Vicriviroc|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stapler Hepatectomy for Elective Liver Resection
Status: COMPLETED
Conditions: Hepatic Resection
Interventions: PROCEDURE: Clamp-Crush technique|PROCEDURE: Stapler hepatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing the Ocular Surface Prior to Cataract Surgery
Status: COMPLETED
Conditions: Corneal Dystrophy, Epithelial Basement Membrane
Interventions: DEVICE: cryopreserved amniotic membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dual Vaccine Trial in Myeloproliferative Neoplasms
Status: COMPLETED
Conditions: Polycythemia Vera|Essential Thrombocythemia
Interventions: DRUG: PD-L1 peptide: PD-L1 Long(19-27) Peptide sequence: FMTYWHLLNAFTVTVPKDL|DRUG: Arginase1 peptide: ArgLong2(169-206) Peptide sequence ISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Camrelizumab Combined With Chemotherapy for Resectable Stage IIIA-IIIB NSCLC
Status: RECRUITING
Conditions: IMMUNOTHERAPY|Neoadjuvant Therapy|Resectable Lung Non-Small Cell Carcinoma|Biomarkers / Blood
Interventions: DRUG: Camrelizumab Plus Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Sorafenib With Androgen Deprivation and Radiotherapy to Treat Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Leuprolide acetate, Bicalutamide, Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Vancomycin Ophthalmic Ointment in Patients With Moderate to Severe Bacterial Conjunctivitis
Status: COMPLETED
Conditions: Bacterial Conjunctivitis
Interventions: DRUG: Vancomycin 1.1%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation and PTH Response Among Malaysian Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Placebo, 500 mg calcium|DIETARY_SUPPLEMENT: 600 IU vitamin D + 500 mg calcium|DIETARY_SUPPLEMENT: 1200 IU vitamin D + 500 mg calcium|DIETARY_SUPPLEMENT: 4000 IU vitamin D + 500 mg calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combined Immunotherapies in Metastatic ER+ Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: RADIATION: Stereotactic Body Radiation Therapy (SBRT) (50GY in 5 fractions)|DRUG: Letrozole 2.5Mg Tab|DRUG: Palbociclib 125mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Efficacy of Nab-PHP and TCbHP in Neoadjuvant Therapy for HER2 Positive Operable Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer,Her2 Positive
Interventions: DRUG: Albumin binding paclitaxel+ trastuzumab+ patuzumab|DRUG: Docetaxel+ carboplatin+ trastuzumab + patuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Plantar Electrical Stimulation Intervention During Hemodialysis to Improve Balance and Mobility
Status: RECRUITING
Conditions: Diabetes Mellitus|Hemodialysis Complication|Cardiovascular Complication|Quality of Life
Interventions: DEVICE: Tennant Biomodulator ®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Use of Antibiotic Sinonasal Rinse After Sinus Surgery
Status: COMPLETED
Conditions: Chronic Rhinosinusitis
Interventions: DRUG: Mupirocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transdiagnostic REBT Prevention Program for Adolescents
Status: COMPLETED
Conditions: Social Anxiety|Major Depression Mild|Panic Disorder|Specific Phobia|Generalized Anxiety Disorder
Interventions: BEHAVIORAL: video-based transdiagnostic REBT|BEHAVIORAL: Wait list
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 3, Long-Term Safety Study of Intravenous Epoetin Hospira in Patients With Chronic Renal Failure Requiring Hemodialysis and Receiving Epoetin Maintenance Treatment. AiME - Anemia Management With Epoetin
Status: COMPLETED
Conditions: Chronic Renal Failure Requiring Hemodialysis
Interventions: BIOLOGICAL: Epoetin Hospira
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Test The Effect Of Apatinib On P450 Enzymes
Status: UNKNOWN
Conditions: Cytochrome P450 Interaction
Interventions: DRUG: Apatinib|DRUG: Nifedipine GTIS|DRUG: Warfarin Potassium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Empowerment Training on Type 2 Diabetes Patients on Empowerment Levels and Clinical Findings
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Empowerment|Patient Empowerment
Interventions: BEHAVIORAL: Diabetes self- management education (DSME) program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tissue Characterization in Teeth Treated With a Regeneration Protocol
Status: COMPLETED
Conditions: Pulp Necrosis
Interventions: DRUG: Triple Antibiotic Paste|DRUG: Triple Antibiotic Paste|DRUG: Triple Antibiotic Paste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Open-label, Uncontrolled Study of ONO-4578 and ONO-4538 in Combination With Standard-of-care Modified FOLFIRINOX (mFFX) or Gemcitabine Plus Nab-paclitaxel (GnP) Therapy as First-line Treatment in Patients With Metastatic Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: ONO-4578|DRUG: ONO-4538|DRUG: Oxaliplatin|DRUG: Levofolinate|DRUG: Irinotecan|DRUG: Fluorouracil|DRUG: Gemcitabine|DRUG: Nab-Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Dietary Supplement on Markers of Glucose Control and Quality of Life
Status: COMPLETED
Conditions: Blood Glucose
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Chromium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prospective Randomized Study on Clinical Effectiveness of Carvo-Tricuspid Isthmus Block in Patients With Paroxysmal Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: PVI, CTI block|PROCEDURE: PVI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neuropsychiatry and Cognition in SCA3/MJD
Status: UNKNOWN
Conditions: Spinocerebellar Ataxia Type 3|Machado-Joseph Disease|SCA3|MJD
Interventions: DIAGNOSTIC_TEST: SCA3/MJD molecular diagnosis|DIAGNOSTIC_TEST: Cognitive Testing|DIAGNOSTIC_TEST: Psychiatric Evaluation|DIAGNOSTIC_TEST: Clinical Neurological Evaluation|DIAGNOSTIC_TEST: Emotional Attribution Evaluation|DIAGNOSTIC_TEST: Activities of Daily Living
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Metformin to Reduce Heart Failure After Myocardial Infarction
Status: COMPLETED
Conditions: ST Elevation Myocardial Infarction (STEMI)|Coronary Artery Disease|Heart Failure|Diabetes
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label Extension Study to Evaluate the Safety and Tolerability of Perampanel (E2007) Administered as an Adjunctive Therapy in Epilepsy Subjects
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Perampanel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Bispecific PSMAxCD3 Antibody CC-1 in Patients With Castration Resistant Prostate Carcinoma
Status: RECRUITING
Conditions: Castration-Resistant Prostatic Cancer
Interventions: DRUG: CC-1, PSMAxCD3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DOvEE - Diagnosing Ovarian & Endometrial Cancer Early
Status: RECRUITING
Conditions: Ovarian Neoplasms
Interventions: OTHER: Blood test: CA-125 biomarker|OTHER: Second Test: Transvaginal Ultrasound|OTHER: Follow-up phone call
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preoperative Dexmedetomidine & EC50 of Propofol
Status: COMPLETED
Conditions: Urologic Surgery
Interventions: DRUG: Group C : Saline + propofol group|DRUG: Group D : Dexmedetomidine + propofol group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mind-Body Interventions to Mitigate Effects of Media Use on Sleep in Early Adolescents
Status: UNKNOWN
Conditions: Sleep Initiation and Maintenance Disorders
Interventions: BEHAVIORAL: Mindful sensory awareness intervention|BEHAVIORAL: Mindful sensory awareness + mindful body awareness check-ins intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sublingual Versus Vaginal Misoprostol In Medical Treatment of Second Trimestric Missed Miscarriage
Status: UNKNOWN
Conditions: Miscarriage
Interventions: DRUG: sublingual misoprostol|DRUG: vaginal misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zanubrutinib, in Combination With Lenalidomide, With or Without Rituximab in Participants With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Status: COMPLETED
Conditions: Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Zanubrutinib|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NightWare and Cardiovascular Health in Adults With PTSD
Status: ACTIVE_NOT_RECRUITING
Conditions: Posttraumatic Stress Disorder|Cardiovascular Diseases|Autonomic Dysfunction|Vascular Stiffness|Nightmare|Endothelial Dysfunction
Interventions: DEVICE: NightWare|DEVICE: Sham NightWare
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety, Effectiveness, and Pharmacokinetics of AA4500 for the Treatment of Edematous Fibrosclerotic Panniculopathy (Commonly Known as Cellulite)
Status: COMPLETED
Conditions: Edematous Fibrosclerotic Panniculopathy|Cellulite
Interventions: BIOLOGICAL: COLLAGENASE CLOSTRIDIUM HISTOLYTICUM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy, Phase 1 Study of CMG901
Status: RECRUITING
Conditions: Advanced Solid Tumor|Gastric Cancer|Gastroesophageal Junction Adenocarcinoma|Pancreatic Cancer
Interventions: DRUG: CMG901
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Remediation in Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia|Psychosis
Interventions: OTHER: Cognitive Remediation Therapy|OTHER: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of 123I-IBZM Scintigraphy (a D2 Agonist) in Patients With Pheochromocytoma (PHEO) and/or Paraganglioma (PGL) : Study Pilot
Status: COMPLETED
Conditions: Chromaffin-tissue Derived Tumors
Interventions: OTHER: Scintigraphy in 123I-IBZM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OCT Evaluation 3 Months After Sirolimus Eluting Stent Implantation
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Sirolimus Eluting Stent Inspiron|DEVICE: Bare Metal Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycerin Suppositories for Treatment of Feeding Intolerance in Preterm Infants
Status: UNKNOWN
Conditions: Feeding Intolerance
Interventions: DRUG: Glycerin|PROCEDURE: Rectal stimulation|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cisplatin,Docetaxel and S-1 for Advanced Gastric and Gastroesophageal Junction Cancer
Status: UNKNOWN
Conditions: Gastric Cancer|Gastroesophageal Junction Cancer
Interventions: DRUG: Docetaxel|DRUG: Cisplatin|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Correction of Facial Wrinkles and Folds and Safety of YVOIRE Volume Versus Perlane in Nasolabial Fold Injection
Status: COMPLETED
Conditions: Temporary Correction of Wrinkles
Interventions: DEVICE: HA IDF II|DEVICE: Perlane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surfactant Lavage vs. Bolus Surfactant in Neonates With Meconium Aspiration
Status: UNKNOWN
Conditions: Meconium Aspiration Syndrome
Interventions: DRUG: Bovine Lipid Extract Surfactant (administered by lavage)|DRUG: Bovine Lipid Extract Surfactant (administered by bolus)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Effect of WelChol Tablets on Cholesterol in Patients Who Have Been Taking Atorvastatin for at Least 4 Weeks.
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: colesevelam HCl tablets, and atorvastatin tablets|DRUG: colesevelam HCl placebo tablets and atorvastatin tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sound and Music for Mild Cognitive Impairment
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: A: 40 Hz music|BEHAVIORAL: B: 40 Hz sound|BEHAVIORAL: C: Preferred music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, Pharmacokinetics and Antitumor Activity of FCN-437c
Status: UNKNOWN
Conditions: Breast Neoplasms
Interventions: DRUG: FCN-437c|DRUG: Letrozole 2.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ARN 509 Plus Everolimus in Men With Progressive Metastatic Castration-Resistant Prostate Cancer After Treatment With Abiraterone Acetate
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: apalutamide|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Impact of a School-based Fruit and Vegetable Co-op on Cardiometabolic Child and Parents Health in a Persistent Poverty Area
Status: RECRUITING
Conditions: Child Obesity|Cardiometabolic Health
Interventions: OTHER: Brighter Bites
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Brain PERfusion Evaluation by Contrast-Enhanced UltraSound
Status: RECRUITING
Conditions: Cerebral Hemorrhage|Subarachnoid Hemorrhage|Ischemic Stroke|Cerebrovascular Circulation|Perfusion
Interventions: DIAGNOSTIC_TEST: Measuring contrast-enhanced ultrasound perfusion with phase inversion harmonic imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Neoadjuvant Regimen for Radioactive Iodine Treatment of Metastatic and Advanced Differentiated Thyroid Cancers
Status: UNKNOWN
Conditions: Thyroid|Metastasis|Apatinib
Interventions: DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D and Its Receptor Gene Polymorphisms in Lithuanian, Latvian and Taiwanese Patients With Atopic Dermatitis and Asthma
Status: UNKNOWN
Conditions: Atopic Dermatitis|Asthma
Interventions: DIAGNOSTIC_TEST: Peripheral vein punction|DIAGNOSTIC_TEST: Stool collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Antidepressant Medication for Reducing HIV Risk Behavior in Depressed Intravenous Drug Users
Status: COMPLETED
Conditions: Depression|Substance-Related Disorders|HIV Infections
Interventions: DRUG: Antidepressant Medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Placebo-Controlled Study of Mirtazapine for PTSD
Status: COMPLETED
Conditions: Anxiety|PTSD
Interventions: DRUG: Mirtazapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Providing Financial Incentives to Improve Adherence to Referral Eye Care Visits
Status: ACTIVE_NOT_RECRUITING
Conditions: Glaucoma|Diabetic Retinopathy|Refractive Errors|Cataract|Behavior, Health
Interventions: OTHER: No Financial Incentive|BEHAVIORAL: Financial Incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Phase 2a Study to Evaluate Optimum Dosage and Stability of DW-3101 in Gastric Inflammation Patients
Status: UNKNOWN
Conditions: Acute and Chronic Gastric Inflammation Patients
Interventions: DRUG: DW-3101_150mg|DRUG: DW-3101_300mg|DRUG: DW-3101_600mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transition to Rebif New Formulation
Status: COMPLETED
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: Rebif New Formulation + prophylactic Ibuprofen|DRUG: Rebif New Formulation + ibuprofen PRN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Safety and Interaction Between Casopitant and Ketoconazole When Taken By Healthy Adults
Status: COMPLETED
Conditions: Nausea and Vomiting, Chemotherapy-Induced
Interventions: DRUG: Casopitant 150 mg|DRUG: Ketoconazole|DRUG: Casopitant 150 mg matching placebo|DRUG: Casopitant 50 mg|DRUG: Casopitant 50 mg matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: |Primary Purpose: TREATMENT
Clinical trial: Study Comparing Two Types of Psychotherapy for Treating Depression and Substance Abuse
Status: COMPLETED
Conditions: Alcohol Abuse|Cannabis Abuse|Major Depressive Disorder|Substance-Related Disorders
Interventions: BEHAVIORAL: Integrated Cognitive Behavioral Therapy|BEHAVIORAL: Twelve Step Facilitation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Effects of ROSE-010 on GI Transit in Constipation Predominant Irritable Bowel Syndrome (C-IBS) Patients
Status: COMPLETED
Conditions: Irritable Bowel Syndrome Constipation Predominant
Interventions: DRUG: ROSE-010|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD) and Food Effect of Single or Repeat Doses of GSK2793660 in Healthy Subjects
Status: TERMINATED
Conditions: Bronchiectasis
Interventions: DRUG: GSK2793660 solution|DRUG: GSK2793660 capsule|DRUG: Placebo solution|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Orlistat (Xenical) in the Treatment of Overweight Patients With Nonalcoholic Steatohepatitis (NASH)
Status: COMPLETED
Conditions: Fatty Liver|Hepatitis
Interventions: DRUG: Orlistat (Xenical)|BEHAVIORAL: 1400 kcal diet (30% fat)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy in Treatment of Facial Melasma Combined With Thulium 1927-nm Fractional Laser and Topical H2R Antagonist
Status: COMPLETED
Conditions: Melasma
Interventions: COMBINATION_PRODUCT: topical H2R antagonist|DEVICE: Thulium 1927-nm Fractional Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Laryngoscopic View to Enable GlideScope-assisted Tracheal Intubation
Status: COMPLETED
Conditions: Time it Takes to Successfully Intubate the Patient With the GlideScope|Time to Intubate Between the Two Views
Interventions: DEVICE: Glidescope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: iAssist vs. Conventional Instrumentation in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Avascular Necrosis|Post-traumatic; Arthrosis|Knee Osteoarthritis
Interventions: PROCEDURE: total knee arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine and Radiation Therapy Compared With Gemcitabine Alone in Treating Patients Who Have Undergone Surgery for Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: gemcitabine hydrochloride|PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Polysomnographic Study to Compare the Efficacy of Gastric Retentive Zaleplon Accordion Pill to Placebo in Subjects With Insomnia
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: Zaleplon AP formulation|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics for Treatment of Chalazion in Adults
Status: COMPLETED
Conditions: Chalazion
Interventions: OTHER: conservative treatment|DIETARY_SUPPLEMENT: probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Maximizing Treatment Outcome and Examining Sleep in Post-traumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: BEHAVIORAL: Prolonged Exposure|BEHAVIORAL: Exercise|BEHAVIORAL: Wellness Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of J3 Bioscience Lubricating Intravaginal Ring VR101 to Relieve the Symptoms of Vaginal Dryness
Status: COMPLETED
Conditions: Menopause Related Conditions|Postmenopausal Symptoms
Interventions: DEVICE: VR101 Device (Efficacy)|OTHER: Sham Control Ring|DEVICE: VR101 Device (Safety)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-arterial Y-90 TheraSpheres for Hepatic Metastases From Solid Tumors
Status: COMPLETED
Conditions: Liver Neoplasms
Interventions: DEVICE: TheraSphere, Yttrium-90 glass Microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of MRD Combined With Personalized Vaccine in the Treatment of Postoperative Recurrence Prevention of EOC
Status: RECRUITING
Conditions: Epithelial Ovarian Cancer
Interventions: BIOLOGICAL: Neoantigen polypeptide vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Biomarker Exploratory Study of Dual Blockade of PD1/PDL1 and CTLA4 and Anti-angiogenic Therapy
Status: RECRUITING
Conditions: MSS Metastatic Colorectal Cancers|MSI Solid Tumors Refractory to PD1/PDL1 Antibody Monotherapy
Interventions: OTHER: Multi-omics testing|OTHER: MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Omicron BA.4/5-Delta Strain Recombinant Novel Coronavirus Protein Vaccine (CHO Cells)
Status: COMPLETED
Conditions: Coronavirus
Interventions: BIOLOGICAL: Omicron BA.4/5-Delta strain recombinant novel coronavirus protein vaccine (CHO cells)|BIOLOGICAL: Recombinant novel coronavirus protein vaccine (CHO cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Open Label Study To Evaluate The Long-Term Safety Profiles Of Caduet In Japanese Patients
Status: COMPLETED
Conditions: Hypertension|Hypercholesterolemia|Angina Pectoris
Interventions: DRUG: Caduet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crossover Bioequivalence Study of Quetiapine Fumarate 25 mg Tablets Under Fasted Conditions
Status: COMPLETED
Conditions: Treatment for Bipolar I Disorder
Interventions: DRUG: Quetiapine Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Lucanix™ Vaccine Therapy in Advanced Non-small Cell Lung Cancer (NSCLC) Following Front-line Chemotherapy
Status: COMPLETED
Conditions: Lung Neoplasm|Carcinoma Non-small Cell Lung Cancer Stage IIIA|Carcinoma Non-small Cell Lung Cancer Stage IIIB|Carcinoma Non-small Cell Lung Cancer Stage IV
Interventions: BIOLOGICAL: Lucanix™|OTHER: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Triple Blockade of the Renin Angiotensin Aldosterone System in Diabetic (Type 1&2) Proteinuric Patients
Status: TERMINATED
Conditions: Microalbuminuria|Macroalbuminuric Diabetic Nephropathy|Diabetes|Proteinuria|Albuminuria
Interventions: DRUG: Aliskiren|DRUG: Aliskiren
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anal Fistula and Microdialysis - What is Yet to Learn?
Status: RECRUITING
Conditions: Anal Fistula
Interventions: DEVICE: OnZurf Probe, Senzime AB, Uppsala, Sweden
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Antiviral Pharmacodynamic Effect, Safety, and Pharmacokinetics of Escalating Doses of BILB 1941 ZW to Patients With Chronic Hepatitis C Genotype 1 Virus Infection
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: BILB 1941 ZW|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: High Flow Nasal Cannula Rates in Pediatric Asthma
Status: NOT_YET_RECRUITING
Conditions: Pediatric Asthma
Interventions: DEVICE: "High Flow" High Flow Nasal Cannula|DEVICE: "Low Flow" High Flow Nasal Cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mindfulness-Based Intervention and Transcranial Direct Current Brain Stimulation to Reduce Heavy Drinking
Status: COMPLETED
Conditions: Alcohol Drinking|Alcohol Intoxication|Alcoholism
Interventions: DEVICE: Brain stimulation with mindfulness-based relapse prevention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ciprofloxacin for the Treatment of Uncomplicated Urinary Tract Infection (uUTI)
Status: COMPLETED
Conditions: UTI - Lower Urinary Tract Infection|Antibiotic Resistant Infection
Interventions: DRUG: Ciprofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-dose Pharmacokinetics of BMS-986177 in Participants With Hepatic Impairment Compared to Healthy Participants
Status: COMPLETED
Conditions: Thrombosis
Interventions: DRUG: BMS-986177
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study to Test Safety and Efficacy of Neurotrophic and Cholinergic Treatment of Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Cerebrolysin + donepezil|DRUG: Cerebrolysin + placebo|DRUG: Donepezil + placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electronic Notification of Teratogenic Risks
Status: COMPLETED
Conditions: Teratogens|Abnormalities, Drug-Induced|Contraception
Interventions: OTHER: Clinical decision support|OTHER: stream-lined clinical alert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Hypoxic Exercise in Lower Extremity Artery Disease
Status: UNKNOWN
Conditions: Peripheral Arterial Disease
Interventions: OTHER: Exercise in hypoxia 1500m|OTHER: Exercise in hypoxia 2500m|OTHER: Exercise in normoxia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An ERP-based Mobile Intervention as an Adjunctive Treatment for OCD
Status: RECRUITING
Conditions: Obsessive-compulsive Disorders and Symptoms|Obsessive-Compulsive Disorder
Interventions: DEVICE: BIXINK OC Free
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Eccentric Versus Isometric Exercise in Reducing Pain in Runners With Proximal Hamstring Tendinopathy
Status: UNKNOWN
Conditions: Proximal Hamstring Tendinopathy|Tendinopathy|Eccentric Exercise|Isometric Exercise|Hamstring Tendon Injury
Interventions: OTHER: Eccentric protocol|OTHER: Isometric protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Intravascular Fluid Resuscitation and Whole Blood Viscosity
Status: COMPLETED
Conditions: Cerebral Aneurysm
Interventions: DRUG: Intravenous Crystalloid|DRUG: Intravenous HES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of SOL (S-1,Oral Leucovorin,and Oxaliplatin) in Patients With Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: S-1, leucovorin, oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnitude of Changes in 25 OH Vitamin D3 Levels After Vitamin D3 Supplementation
Status: WITHDRAWN
Conditions: Vitamin D Deficiency
Interventions: DRUG: vitamin D3 1000 IU orally daily for 5 months|DRUG: vitamin D3 3000 IU orally daily for 5 months|DRUG: vitamin D3 5000 IU orally daily for 5 months|DRUG: Placebo orally daily for 5 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effycacy of Rifaximin on Reverse Minimal Hepatic Encephalopathy and Elimation Small Intestinal Bacterial
Status: TERMINATED
Conditions: Small Intestinal Bacterial Overgrowth|Liver Cirrhosis
Interventions: DRUG: Rifaximin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation for Tinnitus
Status: COMPLETED
Conditions: Tinnitus
Interventions: DEVICE: repetitive transcranial magnetic stimulation (rTMS)|DEVICE: placebo rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Castor Oil Ingestion and Balloon Catheter for Labor Induction in Nulliparous
Status: RECRUITING
Conditions: Induction of Labor Affected Fetus / Newborn
Interventions: DIETARY_SUPPLEMENT: Induction of labor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Maintenance of Efficacy With Risperidone Long Acting Injectable (R-LAI) in Patients With Schizophrenia or Schizoaffective Disorder
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Risperidone Long-acting Injectable (LAI) 25 mg|DRUG: Risperidone LAI 37.5 mg|DRUG: Risperidone LAI 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thermal and Pulsed Ultrasound for Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome|Median Neuropathy, Carpal Tunnel
Interventions: DEVICE: Thermal Ultrasound|DEVICE: Pulsed Ultrasound|DEVICE: Combined Ultrasound|DEVICE: Placebo Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Microfracture With Platelet Rich Plasma Gel Injection for Osteochondral Lesion of the Talus
Status: RECRUITING
Conditions: Osteochondral Lesion of Talus|Microfractures|Platelet Rich Plasma
Interventions: PROCEDURE: Arthroscopic microfracture with intraoperative local PRP gel injection|PROCEDURE: Isolated microfracture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Advanced Gastrointestinal Cancer
Status: COMPLETED
Conditions: Advanced Gastrointestinal Cancer
Interventions: DRUG: BBI608|DRUG: Fluorouracil|DRUG: Oxaliplatin|DRUG: Leucovorin|DRUG: Irinotecan|DRUG: Bevacizumab|DRUG: Capecitabine|DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ethyl Chloride Spray Versus Subcutaneous Lidocaine Anaesthetic Prior to Contraceptive Implant Insertion
Status: WITHDRAWN
Conditions: Contraception
Interventions: OTHER: Questionnaire based study looking at pain scores felt by patients either having a lidocaine injection or ethyl chloride spray prior to insertion of a contraceptive implant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: STRIPES Study: Study To Reduce Infection Post cEsarean Section
Status: COMPLETED
Conditions: Chlorhexidine Gluconate Cloths|Infection; Cesarean Section|Infectious Morbidity|Surgical Site Infections|Endometritis
Interventions: DEVICE: 2% chlorhexidine gluconate (CHG) cloth|DEVICE: Placebo cloth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II Study of Preoperative FOLFIRINOX Versus Gemcitabine/Nab-Paclitaxel in Patients With Resectable Pancreatic Cancer
Status: TERMINATED
Conditions: Resectable Pancreatic Cancer|Pancreatic Ductal Carcinoma
Interventions: DRUG: FOLFIRINOX|DRUG: Gemcitabine/nab-Paclitaxel|RADIATION: Radiation therapy|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Galeterone Compared to Enzalutamide In Men Expressing Androgen Receptor Splice Variant-7 mRNA (AR-V7) Metastatic CRPC
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Galeterone|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Progenitor Cell Transplantation to Treat Inflammatory Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasm|Neoplasm Metastasis
Interventions: DRUG: Monoclonal Antibody 3A1|DRUG: Monoclonal Antibody 95-5-49|DRUG: Monoclonal Antibody 95-6-22|DEVICE: Baxter Isolex 3001 Stem Cell Selection System|DEVICE: Ceprate SC
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: AD109 Dose Finding in Mild to Moderate OSA
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: AD109 dose1- A|DRUG: AD109 dose2- B|DRUG: Placebo- C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT