pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Preoperative Brimonidine on IOP of Patients Undergoing RALP
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: brimonidine tartrate 0.2%|OTHER: Carboxymethylcellulose Eye Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Topical Ethanol Extract (Piper Crocatum) for Anogenital Warts
Status: NOT_YET_RECRUITING
Conditions: Anogenital Wart
Interventions: DRUG: Topical Ethanol Extract (Piper crocatum)|DRUG: Trichloroacetic Acid Topical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Bioequivalence of Two Doses of Tafamidis
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tafamidis free acid tablet|DRUG: Tafamidis meglumine capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Combination of Multiple Doses of RO5285119 With a Single Dose of Risperidone in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: RO5285119|DRUG: RO5285119 placebo|DRUG: risperidone|DRUG: risperidone placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Safety and Efficacy of the Accent Magnetic Resonance Imaging™ (MRI) Pacemaker and Tendril MRI™ Lead
Status: COMPLETED
Conditions: Adverse Effect of MRI on an Implanted Pacemaker Lead|Adverse Effect of MRI on an Implanted Pacemaker
Interventions: DEVICE: Accent MRI system (lead safety)|DEVICE: Accent MRI system (with MRI scan)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Interactive Mobile Phone-Based Brief Intervention to Reduce Substance-Impaired Driving
Status: ENROLLING_BY_INVITATION
Conditions: Driving Impaired
Interventions: BEHAVIORAL: Personalized feedback|BEHAVIORAL: Personalized feedback and text messages|BEHAVIORAL: Information Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Naproxen to Evaluate Various Methods of Measuring Analgesic Effect in Osteoarthritis Pain of the Knee
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Naproxen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Induced Hypothermia in Cardiac Arrest Patients Rescued by Extracorporeal Cardiopulmonary Resuscitation.
Status: UNKNOWN
Conditions: Out-of-Hospital Cardiac Arrest
Interventions: PROCEDURE: hypothermia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis
Status: COMPLETED
Conditions: Interstitial Cystitis
Interventions: DRUG: Dexmedetomidine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study of Enzastaurin in Newly Diagnosed Glioblastoma Multiforme (GBM) and Gliosarcoma (GS) Patients
Status: COMPLETED
Conditions: Glioblastoma|Glioblastoma Multiforme|Gliosarcoma
Interventions: DRUG: enzastaurin|DRUG: temozolomide|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Recurrent Infections Caused by Community Acquired Staphylococcus Aureus (CA-SA) in Children
Status: COMPLETED
Conditions: Community-Acquired Staphylococcus Aureus
Interventions: PROCEDURE: Routine Measures Group|PROCEDURE: Bleach Bath Group (Bleach plus routine measures)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Financial Navigation Program Intervention in Supporting Patients With Solid Tumors and Their Caregivers
Status: COMPLETED
Conditions: Caregiver|Solid Neoplasm
Interventions: OTHER: Educational Intervention|OTHER: Questionnaire Administration|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Ingenol Mebutate Gel for Actinic Keratosis Applied on Large Area on Face, Scalp or Chest
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Ingenol Mebutate|OTHER: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MRI to Assess the Effect of Non-selective Beta-blocker in Patients With Cirrhosis
Status: COMPLETED
Conditions: Portal Hypertension|Cirrhosis|Esophageal Varices|Gastric Varices Bleeding|Varice Bleed|Liver Diseases|Liver Cirrhosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: One Fraction Simulation-Free Treatment With CT-Guided Stereotactic Adaptive Radiotherapy for Patients With Oligometastatic and Primary Lung Tumors
Status: RECRUITING
Conditions: Lung Cancer|Oligometastatic Lung Tumor
Interventions: RADIATION: One fraction stereotactic body radiotherapy|DEVICE: HyperSight|DEVICE: Ethos
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Long-term Carvedilol to Prevent Decompensation or Death in Patients With Asymptomatic Child-Pugh A5 to B8 Cirrhosis and Clinically Significant Portal Hypertension: a Multicenter Double-blind Randomized Control Trial
Status: NOT_YET_RECRUITING
Conditions: Asymptomatic Cirrhosis|Clinically Significant Portal Hypertension
Interventions: DRUG: Experimental group: Patients will be treated with carvedilol.|OTHER: Control group: Patients will receive a placebo.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Cariprazine Oral Capsules or Solution to Assess Adverse Events and Change in Irritability Due to Autism Spectrum Disorder (ASD) in Participants Aged 5-17 Years With ASD
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Cariprazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Montelukast on Kidney and Vascular Function in Type 1 Diabetes
Status: RECRUITING
Conditions: Albuminuria
Interventions: DRUG: Montelukast|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decrease Obstructive Sleep Apnea (OSA) Sympathetic Tone : Impact of APAP vs CPAP
Status: COMPLETED
Conditions: Sleep Apnea Syndromes
Interventions: DEVICE: Fixed CPAP|DEVICE: Auto-adjusting CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Role of the Nitric Oxide (NO) in Pre-oxygenation Before Anesthetic Induction in Patients With a Pulmonary Hypertension in Cardiac Surgery. Pilot Study of Feasibility
Status: UNKNOWN
Conditions: Pulmonary Hypertension
Interventions: DRUG: Nitric oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of PRJ-205 on Performance in Trained Young Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: PRJ-205|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Electrical Stimulation Therapy (EST) of the Lower Esophageal Sphincter (GERD)
Status: TERMINATED
Conditions: GERD
Interventions: PROCEDURE: Laparoscopic IPG and lead implant procedure|DEVICE: Active Electric Stimulation Therapy|DEVICE: Delayed Electric Stimulation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Microwave Ablation Combined With TACE in the Treatment of Unresectable Huge Hepatocellular Carcinoma Huge
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma Non-resectable|Transarterial Chemoembolization|Microwave Ablation
Interventions: PROCEDURE: TACE|PROCEDURE: MWA|DEVICE: MWA system|DRUG: Chemoembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effect of Oxygentherapy on Concentration at Chronic Lung Patients
Status: COMPLETED
Conditions: Lung Diseases, Interstitial|Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cadonilimab (AK104) Plus Chemotherapy in Patients With Recurrent or Advanced Endometrial Cancer
Status: NOT_YET_RECRUITING
Conditions: Endometrial Cancer|Endometrial Adenocarcinoma
Interventions: DRUG: Cadonilimab|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis
Status: RECRUITING
Conditions: Leptomeningeal Metastases
Interventions: DRUG: Deferoxamine (DFO)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-Blind Evaluation of Maple Leaf Extract (Maplifa) for Photoaging
Status: COMPLETED
Conditions: Photoaging|Hyperpigmentation|Rhytides
Interventions: COMBINATION_PRODUCT: 1% red maple leaf extract in cream base|COMBINATION_PRODUCT: 5% red maple leaf extract|COMBINATION_PRODUCT: vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple-Dose Study of Effect of Bardoxolone Methyl on QT/QTC Interval Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Bardoxolone Methyl 20mg|DRUG: Bardoxolone Methyl 80mg|DRUG: Bardoxolone Methyl Placebo|DRUG: Moxifloxacin 400mg|DRUG: Moxifloxacin Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 18F-FLT PET Imaging in Patients With Advanced Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: fludeoxyglucose F 18|DEVICE: Positron emission tomography-computed tomography|DRUG: 18F-fluorothymidine|DEVICE: Positron emission tomography-magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effect of Short-term Simulated Altitude Exposure on Cardiopulmonary Functional Capacity
Status: TERMINATED
Conditions: Hypoxia
Interventions: OTHER: Hypoxia|OTHER: Normoxia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single Ascending Dose of ZSP1603 in Healthy Adults
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis(IPF)|Solid Tumor
Interventions: DRUG: ZSP1603 7.5 mg|DRUG: ZSP1603 12.5 mg|DRUG: Placebo 12.5mg|DRUG: ZSP1603 25 mg|DRUG: Placebo 25mg|DRUG: ZSP1603 50 mg|DRUG: Placebo 50mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: N-Acetylcysteine in Patients With Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: N-Acetylcysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Effectiveness of the "Hello Bundle" Intervention in Reducing Burnout Among ICU Healthcare Professionals
Status: NOT_YET_RECRUITING
Conditions: Prevalence of Burn-out Among Intensive Care Professionals
Interventions: BEHAVIORAL: Hello bundle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Method of Pre-treatment for Application of QUTENZA Capsaicin 8% Patch
Status: COMPLETED
Conditions: or Peripheral Nerve Injury (PNI)|Peripheral Neuropathic Pain (PNP) Due to Postherpetic Neuralgia (PHN)
Interventions: DRUG: QUTENZA|DRUG: Lidocaine|DRUG: Tramadol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Self Sampling for Rapid Turnaround Testing in the Emergency Department
Status: COMPLETED
Conditions: Chlamydia Trachomatis|Neisseria Gonorrhoeae
Interventions: PROCEDURE: vaginal self sampling|PROCEDURE: provider-performed endocervical sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Randomized Placebo Controlled Trial Evaluating the Efficacy of Pimavanserin, a Selective Serotonin 5-HydroxyTryptamine-2A (5HT2A) Inverse Agonist, to Treat Impulse Control Disorders in Parkinson's Disease.
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: Active drug: pimavanserin 17mg (2 strength tablets)|DRUG: Placebo: 2 tablets containing same excipients except active compound|BEHAVIORAL: Assessment of severity of ICD (impulse control disorders)|BEHAVIORAL: Assessment of motor and non-motors symptoms of PD Evaluation of hyper- and hypodopaminergic behaviors|BEHAVIORAL: Assessment of quality of life|BEHAVIORAL: Assessment of depression|BEHAVIORAL: Assessment of cognition|BEHAVIORAL: Assessment of severity of Parkinson Disease|PROCEDURE: Blood analysis|PROCEDURE: Cardiac monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endometrial Safety Study of a 0.5 mg Estradiol and 2.5 mg Dydrogesterone Combination
Status: COMPLETED
Conditions: Postmenopause
Interventions: DRUG: 0.5 Mg Estradiol and 2.5 Mg Dydrogesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Pharmacokinetics of CDX-0158 in Adult Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: BIOLOGICAL: CDX-0158 (formerly known as KTN-0158)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Injection of Botulinum Toxin on Motor Function and Gait Pattern in Stroke Patients
Status: COMPLETED
Conditions: Stroke|Spasticity
Interventions: PROCEDURE: Botox_A|PROCEDURE: Botox_B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Oral Topotecan With Bevacizumab for Recurrent Small Cell Lung Cancer
Status: COMPLETED
Conditions: Recurrent Small-cell Lung Cancer (SCLC)|Lung Cancer, Small Cell
Interventions: DRUG: Oral Hycamtin (topotecan) Capsules + IV Avastin (bevacizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Screening of Phytochemical Rich Ingredients as 'Functional Foods' to Improve Cardiometabolic Health
Status: COMPLETED
Conditions: Metabolic Disease
Interventions: OTHER: Control|OTHER: Cumin Rice|OTHER: Cumin Drink|OTHER: Cornsilk Rice (Low dose)|OTHER: Cornsilk Rice (High dose)|OTHER: Cornsilk Drink (Low dose)|OTHER: Cornsilk Drink (High dose)|OTHER: Tamarind Rice|OTHER: Tamarind Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Vismodegib in Treating Younger Patients With Recurrent or Refractory Medulloblastoma
Status: COMPLETED
Conditions: Recurrent Childhood Medulloblastoma
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Vismodegib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Reiki Application on Pain Severity and Quality of Life in Patients Receiving Hemodialysis Treatment
Status: COMPLETED
Conditions: Hemodialysis
Interventions: OTHER: Reiki|OTHER: Sham Reiki
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Azithromycin Added to Hydrochloroquine in Patients Admitted to Intensive Care With COVID-19: Randomised Controlled Trial
Status: TERMINATED
Conditions: COVID-19|Respiratory Failure
Interventions: DRUG: Azithromycin|DRUG: Hydroxychloroquine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study With Temsirolimus Added to Standard Chemotherapy for Patients Over 60 Years With Acute Myeloblastic Leukemia
Status: COMPLETED
Conditions: Acute Myeloblastic Leukemia
Interventions: DRUG: sodium chloride solution 0.9%|DRUG: temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: IBI397 or Combination Therapies in Patients With Advanced Malignancies
Status: WITHDRAWN
Conditions: Advanced Malignancies
Interventions: DRUG: IBI397|DRUG: IBI397+Sintilimab|DRUG: IBI397+Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: [68Ga]Ga-ABY-025 PET for Quantification of HER2-status in Solid Tumors
Status: RECRUITING
Conditions: Esophageal Neoplasms|Gastric Neoplasms Malignant|Breast Cancer|HER2-positive Gastric Cancer
Interventions: DIAGNOSTIC_TEST: [68Ga]Ga-ABY-025 PET|DIAGNOSTIC_TEST: Biopsy and analysis of HER2 expression
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cardiovascular Responses to Static and Dynamic Exercise in Elderly With Isolated Systolic Hypertension
Status: UNKNOWN
Conditions: Cardiovascular Responses in Elderly With Isolated Systolic Hypertension
Interventions: PROCEDURE: static hand grip exercise|PROCEDURE: cycling exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Multicenter Study Evaluating the Effectiveness of Endo.Angel in Improving the Quality of Colonoscopy
Status: UNKNOWN
Conditions: Adenoma
Interventions: DIAGNOSTIC_TEST: Colonoscopy with assistance of Endo.Angel|DIAGNOSTIC_TEST: Colonoscopy without assistance of Endo.Angel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: A Study of Adeno-Associated Virus Serotype 8-Mediated Gene Transfer of Glucose-6-Phosphatase in Patients With Glycogen Storage Disease Type Ia (GSDIa)
Status: ACTIVE_NOT_RECRUITING
Conditions: Glycogen Storage Disease Type IA
Interventions: GENETIC: DTX401|OTHER: Placebo|DRUG: Oral corticosteroids|DRUG: Placebo for oral corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Delivering Health: Addressing Diabetes and Food Insecurity
Status: COMPLETED
Conditions: Food Insecurity|Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Type 2 Diabetes Appropriate Food Boxes + Diabetes Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: High Concentration Oxygen Therapy for Pneumocephalus in Chronic Subdural Haematoma: A Prospective Observational Study
Status: UNKNOWN
Conditions: Chronic Subdural Hematoma
Interventions: OTHER: Low concentration oxygen group: Room air (0-2Litre Oxygen via Nasal Canula)|OTHER: High concentration oxygen group: Room air (12-15Litre Oxygen via Non-rebreather Mask)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Danhong Injection in the Treatment of Chronic Stable Angina
Status: COMPLETED
Conditions: Chronic Stable Angina
Interventions: DRUG: Danhong injection|OTHER: Standard medical care|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low Add Multifocal Versus Extended Depth of Focus Intraocular Lens
Status: COMPLETED
Conditions: Multifocal Intraocular Lenses|Extended Depth of Focus
Interventions: DEVICE: Tecnis +2.75 D (ZKB00) and Tecnis Symfony (ZXR00)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Meditative Movement (Qigong/Tai Chi Easy) on Fatigued Breast Cancer Survivors
Status: COMPLETED
Conditions: Fatigue
Interventions: OTHER: Qigong/Tai Chi Easy|OTHER: Sham Qigong|OTHER: Educational Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Online Dance Versus Therapeutic Exercise for Parkinson Disease.
Status: ENROLLING_BY_INVITATION
Conditions: Parkinson Disease
Interventions: OTHER: Dance & Music (Online)|OTHER: Multimodal Therapeutic Exercise & Music (Online)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty (RELIFE)
Status: NOT_YET_RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DRUG: Duloxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Allogeneic NK Cell Infusions in Patients With Relapsed/Refractory AML and High Risk MDS
Status: COMPLETED
Conditions: AML, Adult Recurrent|MDS
Interventions: BIOLOGICAL: DVX201
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SIZOMUS Safety of Ixazomib Targeting Plasma Cells in Multiple Sclerosis
Status: RECRUITING
Conditions: Relapsing Remitting Multiple Sclerosis|Primary Progressive Multiple Sclerosis|Secondary Progressive Multiple Sclerosis
Interventions: DRUG: Ixazomib (NINLARO®) capsules / Matching placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study Using Whole-body PET After Oral Microdose of 18F-labeled Liporaxel in Patients With Solid Tumor
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of a Novel Neuroplasticity-based Neurobehavioral Intervention for PTSD
Status: COMPLETED
Conditions: Anxiety|Depression
Interventions: BEHAVIORAL: Computerized Neurobehavioral Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Safety and Effectiveness of Hydroxyurea in Patients on Potent Antiretroviral Therapy and Who Have Less Than 200 Copies/ml of HIV RNA in Their Blood
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Indinavir sulfate|DRUG: Lamivudine/Zidovudine|DRUG: Hydroxyurea|DRUG: Lamivudine|DRUG: Stavudine|DRUG: Zidovudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: GRAVITAS-309: Itacitinib and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease
Status: TERMINATED
Conditions: Chronic Graft-versus-host Disease
Interventions: DRUG: Itacitinib|DRUG: Placebo|DRUG: Methylprednisolone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PhI Study of Erbitux & Gemcitabine w/Radiation Therapy for Locally Adv. Pancreas Ca
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: gemcitabine hydrochloride|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant/Adjuvant Pembrolizumab Plus Chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer|Neoadjuvant Therapy|Immune Checkpoint Inhibitor
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iomab-ACT: A Pilot Study of 131-I Apamistamab Followed by CD19-Targeted CAR T-Cell Therapy for Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia or Diffuse Large B-Cell Lymphoma
Status: RECRUITING
Conditions: B-ALL|DLBCL|B ALL|Dlbcl-Ci|DLBCL Unclassifiable|DLBCL, Nos Genetic Subtypes|DLBCL Activated B-Cell Type|DLBCL Germinal Center B-Cell Type|Diffuse Large B-cell Lymphoma|HGBL|HGBL, Nos
Interventions: DRUG: 131-I Apamistamab|BIOLOGICAL: CAR T-cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Ability of dOFM for BE Testing of Topically Applied Diclofenac Sodium Products in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Voltaren - Diclofenac sodium gel 1% (GSK, USA)|DRUG: Pennsaid 2 % Topical Solution (Horizon Therapeutics, USA)|DRUG: Diclofenac sodium gel 1% (Perrigo, USA)|DEVICE: Dermal open flow microperfusion - Pilot|DEVICE: Dermal open flow microperfusion - Pivotal|PROCEDURE: Blood sampling - Pilot|PROCEDURE: Blood sampling - Pivotal
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Fatty Acid Metabolism in Obstructive Sleep Apnea (FAMOSA)
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Fatty Acid Metabolism|Continuous Positive Airway Pressure
Interventions: DEVICE: CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gut Microbiota and Pulmonary Complications After Non Cardiac Elective Surgery in Elderly Patients
Status: RECRUITING
Conditions: Preoperative Oral Pharyngeal and Intestinal Microbiota Spectrum; Postoperative Pulmonary Complications
Interventions: PROCEDURE: Elective upper abdominal surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Integrating Mind-Body Skills With Physical Activity to Improve Physical and Emotional Outcomes in Patients With Chronic Pain
Status: UNKNOWN
Conditions: Pain|Chronic Pain|Physical Activity
Interventions: BEHAVIORAL: GetActive|BEHAVIORAL: Get Active with Fitbit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Surgical Diathermy in Eradicating Cutibacterium Acnes From Surgical Skin Incision During Shoulder Arthroplasty
Status: COMPLETED
Conditions: Infection, Bacterial
Interventions: PROCEDURE: Using surgical diathermy to make skin incision|PROCEDURE: Using scalpel blade to make skin incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Assess The Efficacy and Safety Of Oral Sildenafil in the Treatment of Pulmonary Arterial Hypertension.
Status: TERMINATED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Sildenafil citrate|DRUG: Sildenafil citrate|DRUG: Sildenafil citrate|DRUG: Sildenafil citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ibrutinib for the Prevention of Chronic Graft-Versus-Host Disease in Patients Undergoing Donor Stem Cell Transplant
Status: NOT_YET_RECRUITING
Conditions: Chronic Graft Versus Host Disease|Hematopoietic and Lymphatic System Neoplasm
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Echocardiography|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Preventing Speech and Language Disorders in Children With Classic Galactosemia
Status: ENROLLING_BY_INVITATION
Conditions: Classic Galactosemia|Speech Disorders in Children|Language Disorders in Children
Interventions: BEHAVIORAL: Babble Boot Camp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Novel Auto Segmentation Algorithm for Normal Structure Delineation in Radiation Treatment Planning
Status: NOT_YET_RECRUITING
Conditions: Hematopoietic and Lymphoid System Neoplasm|Malignant Solid Neoplasm
Interventions: OTHER: Non-Interventional Study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetics, Efficacy, Safety, and Immunogenicity of Wilate in Previously Treated Paediatric Patients With Severe Haemophilia A
Status: COMPLETED
Conditions: Severe Hemophilia A
Interventions: DRUG: Wilate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Executive Training and Brain in Children
Status: UNKNOWN
Conditions: Healthy Children|Preterm Birth
Interventions: BEHAVIORAL: Inhibition training|BEHAVIORAL: Working memory training|BEHAVIORAL: Mindfulness training|BEHAVIORAL: Active control training|GENETIC: Saliva collection|PROCEDURE: Brain Magnetic Resonance Imaging|BEHAVIORAL: Cognitive testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacokinetics in Oral and Intranasal Formulations of Zolmitriptan.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Zolmitriptan intranasal.|DRUG: Zolmitriptan oral.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanical Insufflation -Exsufflation in Children With NMD and Weak Cough
Status: COMPLETED
Conditions: Neuromuscular Diseases in Children
Interventions: OTHER: Symmetric settings (high pressures/fast rate)|OTHER: Asymmetric settings (Pi<Pe/Ti>Te)|OTHER: Preinclusion settings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fed Study of Metoprolol Tartrate Tablets 100 mg and Lopressor® 100 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Metoprolol Tartrate Tablets 100 mg|DRUG: Lopressor® Tablets 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of Lenvatinib and Anti-PD1 Antibody Combined With Radiotherapy Neoadjuvant Treatment for Resectable Hepatocellular Carcinoma With PVTT
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Sintilimab|DRUG: Lenvatinib|RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Soft Robotic Exosuit on Exercise Capacity, Biomakers of Neuroplasticity, and Motor Learning After Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Soft exosuit|BEHAVIORAL: No Soft exosuit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Percutaneous Auricular Neuromodulation for Postoperative Analgesia
Status: ENROLLING_BY_INVITATION
Conditions: Postoperative Pain, Acute
Interventions: DEVICE: Active Percutaneous Auricular Neuromodulation with NSS-2 Bridge|DEVICE: Sham Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Two Multi-Drug Therapies in HIV-Infected Patients Who Have Never Received Anti-HIV Treatment
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Lamivudine/Zidovudine|DRUG: Abacavir sulfate|DRUG: Amprenavir|DRUG: Nelfinavir mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Mobile App for Individuals With or at Risk of Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Pain/Osteoarthritis|Digital Health
Interventions: DEVICE: mRehab app|DEVICE: Sham app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Supervised Treadmill Exercise and Ranolazine for Intermittent Claudication of Lower Extremities
Status: TERMINATED
Conditions: Peripheral Arterial Disease
Interventions: DRUG: Ranolazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Axitinib as Neoadjuvant Therapy for Locally Advanced Non-metastatic Clear Cell Renal Cell Carcinoma
Status: UNKNOWN
Conditions: Renal Cell Carcinoma|Clear Cell Renal Cell Carcinoma
Interventions: DRUG: Pembrolizumab|DRUG: Axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Seasonal Malaria Chemoprevention Versus Home Management of Malaria in Children Under 5 Years in Ghana
Status: COMPLETED
Conditions: Malaria|Anaemia
Interventions: DRUG: Artemether-lumefantrine combination|DRUG: Dihydroartemisinin Piperaquine combination|DRUG: Amodiaquine plus sulphadoxine-pyrimethamine combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Single Dose Tramadol Effect on Extubation Response and Quality of Emergence Post-supratentorial Intracranial Surgery
Status: COMPLETED
Conditions: Brain Neoplasm
Interventions: DRUG: Injection Tramadol|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Meloxicam Compared to Other Nonsteroidal Antiinflammatory Drugs (NSAIDs) in an Observational Cohort Study of Patients With Rheumatoid Arthritis, Osteoarthritis, Lumbago, Scapulohumeral Periarthritis, Neck, Shoulder and Arm Syndrome
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Meloxicam|DRUG: Other Non Steroidal Anti-Inflammatory Drugs (NSAIDs) except etodolac
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Effect of Rifampin on the Pharmacokinetics of Vonoprazan in Healthy Participants
Status: WITHDRAWN
Conditions: Healthy Participants
Interventions: DRUG: Vonoprazan|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Diet, ExerCIse and carDiovascular hEalth (DECIDE) - Salt Reduction Strategies for the Elderly in Nursing Homes in China
Status: COMPLETED
Conditions: Blood Pressure
Interventions: OTHER: SS|OTHER: SSSC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Study: Hepatoprotective Role of SMOFlipid® Used in Short-term Parenteral Nutrition in an Onco-Hematology Pediatric Population
Status: COMPLETED
Conditions: Dietary and Nutritional Therapies
Interventions: DRUG: Smoflipid|DRUG: Médialipides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Lactobacillus Reuteri DSM 17938 on Immunomodulation and Gastric Motility in Preterm Newborns
Status: COMPLETED
Conditions: Preterm Birth
Interventions: DIETARY_SUPPLEMENT: Lactobacillus Reuteri|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lung Cancer Information Study (LCIS-R01)
Status: COMPLETED
Conditions: Non-Small-Cell Lung Cancer
Interventions: BEHAVIORAL: Enhanced Care (intervention group and comparison group)|BEHAVIORAL: Usual care (routine chemotherapy cycles and imaging studies)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: N-Acetyl Glucosamine as Therapeutic Intervention for Coronavirus Disease-19 (COVID-19)
Status: COMPLETED
Conditions: Coronavirus|Covid19
Interventions: DIETARY_SUPPLEMENT: N-acetyl glucosamine (NAG)|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Impact of Automated Evaluation of Gastrointestinal Symptoms (AEGIS) on Clinical Outcomes
Status: COMPLETED
Conditions: Abdominal Pain|Deglutition Disorders|Fecal Incontinence|Nausea|Diarrhea|Constipation|Gastroesophageal Reflux
Interventions: OTHER: AEGIS (Automated Evaluation of Gastrointestinal Symptoms)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effects of Traditional Chinese Medicine Mouthwash Solutions on the Oral Health of Leprosy Patients
Status: COMPLETED
Conditions: Leprosy|Hansen's Disease|Xerostomia|Plaque
Interventions: OTHER: Traditional Chinese Medicine mouthwash|OTHER: Dilute 50 times of Traditional Chinese Medicine mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Dietary Fiber Intervention on Patients With Polycystic Ovary Syndrome
Status: RECRUITING
Conditions: Polycystic Ovary Syndrome
Interventions: DIETARY_SUPPLEMENT: Dietary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Prospective Randomized Trial of Static-Progressive Versus Dynamic Splinting for Post-Traumatic Elbow Stiffness
Status: COMPLETED
Conditions: Post-traumatic Stiff Elbows
Interventions: DEVICE: Static-Progressive Splint|DEVICE: Dynamic Splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Safety of Technosphere® Insulin (TI) in Diabetic Subjects With Moderate Obstructive Pulmonary Disease
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus|Moderate Chronic Obstructive Pulmonary Disease|Asthma
Interventions: DRUG: Technosphere® Insulin|DRUG: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dextromethorphan Pediatric Acute Cough Study
Status: TERMINATED
Conditions: Cough
Interventions: DRUG: Dextromethorphan Hydrobromide|DRUG: Placebo|DEVICE: Cough recording device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Subjects With Limbal Stem Cell Deficiency
Status: RECRUITING
Conditions: Limbal Stem Cell Deficiency
Interventions: BIOLOGICAL: CSB-001 Ophthalmic Solution 0.1%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Twice Daily vs. Once Daily Bronchodilation on Hyperinflation in COPD Patients During 24 Hours.
Status: UNKNOWN
Conditions: Chronic Obstructive Airway Disease
Interventions: DRUG: Tiotropium 'Respimat' 5 mcg|DRUG: Aclidinium Bromide/Formoterol Fumarate 340/12 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Veliparib and Dinaciclib in Treating Patients With Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Solid Neoplasm
Interventions: DRUG: Dinaciclib|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SAPT Versus DAPT in Incomplete Revascularization After CABG
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DRUG: Ticagrelor|DRUG: acetylsalicylic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Surgical Mask, FFP2 Mask and FFP3 Mask (With and Without Exhalation Valve) on Exercise Tolerance and Blood Gas Parameters of Patients With Known Lung Disease and Long-term Oxygen Therapy
Status: COMPLETED
Conditions: Face Mask|Longterm Oxygen Therapy
Interventions: DIAGNOSTIC_TEST: 6-MWT|DIAGNOSTIC_TEST: Spiroergometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lactoferrin for Prevention of Sepsis in Infants
Status: COMPLETED
Conditions: Late Onset Neonatal Sepsis
Interventions: DIETARY_SUPPLEMENT: Bovine Lactoferrin|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Process Validation in Dermatology: Assessing Wound Creation Methods and Treatment Efficacy
Status: COMPLETED
Conditions: Validation of the Process of Wound Creation and Evaluation
Interventions: OTHER: Moisturising Cream (5%)|OTHER: Moisturising Cream (10%)|OTHER: Coconut Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Randomized Study to Assess the Relative Bioavailability of New Formulations of GSK1265744 Long Acting Parental (LAP) in Healthy Adult Subjects
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: GSK1265744 30 mg oral|DRUG: Midazolam 3 mg oral + GSK1265744 30mg oral|DRUG: GSK1265744 400 mg (200 nm)|DRUG: GSK1265744 400 mg (1 micro m)|DRUG: GSK1265744 400 mg (5 micro m)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Viome's Precision Nutrition Program Towards Reducing HbA1c
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes|Pre Diabetes
Interventions: DIETARY_SUPPLEMENT: Viome's Precision Nutrition Program (VPNP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Brentuximab Vedotin in Early Stage Hodgkin Lymphoma
Status: RECRUITING
Conditions: Hodgkin Lymphoma
Interventions: RADIATION: Involved site radiotherapy|DRUG: Doxorubicin|DRUG: Bleomycin|DRUG: Brentuximab vedotin|DRUG: Vinblastine|DRUG: Dacarbazine|DRUG: Haematopoietic growth factor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Huaier Granule for Prevention of Disease Progression of Hepatocarcinoma After Non-radical Hepatectomy
Status: TERMINATED
Conditions: Hepatic Carcinoma
Interventions: DRUG: Huaier Granule
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Vitamin D in Untreated Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: FOLFOX + bevacizumab|DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT