pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Value of Advanced MR Imaging in Gynecological Tumors and Benign Uterine Fibroids
Status: TERMINATED
Conditions: Gynecologic Tumor
Interventions: DEVICE: Magnetic Resonance Fingerprinting (MRF)|DEVICE: Q-space Trajectory Imaging (QTI)|DEVICE: Magnetic Resonance Imaging Machine (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Linaclotide to Senna for CIC
Status: TERMINATED
Conditions: Chronic Idiopathic Constipation
Interventions: DRUG: Senna|DRUG: Linzess
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Resveratrol-enriched Grape Extract (Stilvid) in Primary and Secondary Prevention of Cardiovascular Disease
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DIETARY_SUPPLEMENT: Placebo in primary cardiovascular prevention (PP)|DIETARY_SUPPLEMENT: Placebo in secondary prevention|DIETARY_SUPPLEMENT: Grape extract in primary prevention (PP)|DIETARY_SUPPLEMENT: Grape extract in SP|DIETARY_SUPPLEMENT: Resveratrol-enriched grape extract in PP|DIETARY_SUPPLEMENT: Resveratrol-enriched grape extract in SP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Impact of Adjuvants Accompanying Peptide Immunization in High-Risk Melanoma
Status: COMPLETED
Conditions: High-Risk Melanoma
Interventions: DRUG: gp100:209-217 (210M)|DRUG: Montanide ISA-51|DRUG: Imiquimod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Interscalene Block and Suprascapular With Axillary Block
Status: COMPLETED
Conditions: Shoulder Arthroplasty|Ultrasound Guided
Interventions: PROCEDURE: interscalene block|PROCEDURE: suprascapular block + axillary block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Orthostatic Hypotension With Electric Stimulation in Persons With Acute SCI
Status: COMPLETED
Conditions: Spinal Cord Injury|Orthostatic Hypotension
Interventions: PROCEDURE: ES of the abdominal muscles|PROCEDURE: ES of the limb muscles|PROCEDURE: ES of limbs & abdomen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Computer Assisted Planing of Corrective Osteotomy for Distal Radius Malunion
Status: COMPLETED
Conditions: Extraarticular Distal Radius Malunion
Interventions: PROCEDURE: Computer-Assisted Surgical Planning|PROCEDURE: distal radius osteotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy and Safety of Three Formulations of Ultra-low Dose Estriol Vaginal Gel (0.005%, 0.002%, 0.0008% Estriol Vaginal Gel) for the Treatment of Vaginal Dryness in Postmenopausal Women With Vulvovaginal Atrophy
Status: COMPLETED
Conditions: Vaginal Atrophy
Interventions: DRUG: Estriol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cabozantinib-S-Malate and Erlotinib Hydrochloride in Treating Patients With Previously Treated Metastatic Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Recurrent Non-Small Cell Lung Carcinoma|Stage IV Non-Small Cell Lung Cancer AJCC v7
Interventions: DRUG: Cabozantinib S-malate|DRUG: Erlotinib Hydrochloride|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Osimertinib With Carotuximab in Advanced, EGFR-mutated Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer|Lung Cancer
Interventions: DRUG: Osimertinib|DRUG: Carotuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Acupuncture on Ovarian Function and Pregnancy Outcomes in Women With Decreased Ovarian Reserve
Status: RECRUITING
Conditions: Decreased Ovarian Reserve
Interventions: DEVICE: acupuncture|DEVICE: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Modified Broselow Tape and Cole Formula
Status: COMPLETED
Conditions: Predicting Uncuffed Endotracheal Tube Size in Pediatric Anesthesia
Interventions: PROCEDURE: Modification Broselow Tape|PROCEDURE: Cole Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Micronutrient Supplement for Nurse Burnout
Status: UNKNOWN
Conditions: Burnout, Professional|Stress, Psychological
Interventions: DIETARY_SUPPLEMENT: MagnéVie B6®|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation Of The Nano Lv Lead System In Chronic Situation (LENEA)
Status: TERMINATED
Conditions: LV Lead|LV Therapy|LV Treatment|LV Microcable
Interventions: DEVICE: implantation of the new LV lead: NANO system.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Immunogenicity and Safety of Sequential Booster Immunization of Recombinant Novel Coronavirus Vaccine (CHO Cells) for SARS-CoV-2
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Recombinant Novel Coronavirus vaccine (CHO Cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Irinotecan Plus Mitomycin in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: irinotecan hydrochloride|DRUG: mitomycin C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of SGLT2 Inhibition in Pediatric Steatotic Liver Disease
Status: NOT_YET_RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: DRUG: Empagliflozin 10 MG|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of a Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases
Status: COMPLETED
Conditions: Measles|Rubella|Mumps|Varicella
Interventions: BIOLOGICAL: Measles, Mumps, Rubella and Chickenpox (live vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Gut Flora Dependent Metabolism of Dietary Phosphatidylcholine and Cardiovascular Disease
Status: COMPLETED
Conditions: Nutrition
Interventions: OTHER: Antibiotic (metronidazole and ciprofloxacin)/probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 1 Clinical Trial of Lenvatinib, Pembrolizumab and Hypofractionated Pelvic Radiation Therapy for pMMR Recurrent/Unresectable Endometrial Carcinoma
Status: RECRUITING
Conditions: Recurrent Endometrial Carcinoma|Unresectable Endometrial Carcinoma
Interventions: DRUG: Lenvatinib|DRUG: Pembrolizumab|RADIATION: Hypofractionated External Beam Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Subanesthetic Dose of Ketamine Given on Postoperative Mood in Patients Undergoing Fractional Curettage
Status: COMPLETED
Conditions: Ketamine|Minor Surgical Procedure|Total Mood Score|Woman
Interventions: DRUG: Ketamine|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: How to Predict Postoperative Complications After Early Laparoscopic Cholecystectomy for Acute Cholecystitis: the Chole-Risk Score
Status: COMPLETED
Conditions: Cholecystitis, Acute
Interventions: PROCEDURE: Early Laparoscopic Cholecystectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of Oral Probiotics and Herbal Supplementation on the Gut Microbiome and Sebum Excretion Rate in Non-Cystic Acne
Status: ACTIVE_NOT_RECRUITING
Conditions: Acne Vulgaris|Acneiform Eruptions|Skin Diseases|Sebaceous Gland Diseases
Interventions: OTHER: Probiotic|DIETARY_SUPPLEMENT: Oral herbal powder supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of PrevenaTM on Clean Closed Sternal Midline Incisions in Subjects at High Risk for Surgical Site Occurrences.
Status: TERMINATED
Conditions: Surgical Site Occurences After Sternotomy|Wound Infection
Interventions: DEVICE: Prevena™ Incision Management System|DEVICE: Conventional sterile wound dressings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Cyclosporine Followed by Focal Therapy for Bilateral Retinoblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Retinoblastoma
Interventions: BIOLOGICAL: filgrastim|DRUG: Carboplatin|DRUG: Cyclosporine|DRUG: Etoposide|DRUG: vincristine sulfate|PROCEDURE: cryosurgery|PROCEDURE: laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Panitumumab, Paclitaxel, Carboplatin and 5FU in the Treatment of Potentially Resectable Gastroesophageal Adenocarcinoma
Status: TERMINATED
Conditions: Gastroesophageal Adenocarcinoma|Adenocarcinoma of the Distal Esophagus|Adenocarcinomas of the Gastroesophageal Junction|Adenocarcinoma of the Proximal Stomach
Interventions: DRUG: Panitumumab|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: 5FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Letrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone Receptor Positive, HER2 Negative Breast Cancer
Status: RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|HER2-Negative Breast Carcinoma|Hormone Receptor-Positive Breast Carcinoma|Invasive Breast Carcinoma
Interventions: DRUG: Letrozole|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Individual Patient Data Meta-analysis on Prehospital Risk Assessment in Patients Suspected of Non-ST-segment Elevation Acute Coronary Syndrome
Status: RECRUITING
Conditions: Acute Coronary Syndrome|Non ST Segment Elevation Acute Coronary Syndrome
Interventions: DEVICE: Combined risk score|OTHER: Usual care|DEVICE: point-of-care troponin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Using Reiki Therapy to Improve Symptoms Associated With Brachytherapy in Patients With Gynecological Malignancies
Status: RECRUITING
Conditions: Gynecologic Neoplasm|Brachytherapy|Therapeutic Touch|Endometrial Cancer|Cervical Cancer|Vaginal Cancer|Vulvar Cancer
Interventions: OTHER: Reiki therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus
Status: RECRUITING
Conditions: Squamous Cell Carcinoma of the Oropharynx|Carcinomas of Unknown Primary Site|High-risk Human Papillomavirus Infection|Liquid Biopsy|Lymph Node Metastasis|Occult Tumor of the Head and Neck Area
Interventions: DIAGNOSTIC_TEST: Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating the Efficacy of Erector Spinae Block in Routine Hip Arthroscopy
Status: UNKNOWN
Conditions: Hip Disease|Postoperative Pain
Interventions: PROCEDURE: Erector spinae block|PROCEDURE: Local block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Efficacy and Safety of ATGC-110 (Botulinum Toxin) With Xeomin® for the Treatment of Moderate to Severe Glabellar Frown Lines
Status: ACTIVE_NOT_RECRUITING
Conditions: Glabellar Frown Lines
Interventions: BIOLOGICAL: ATGC-110|BIOLOGICAL: Xeomin®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Estrogen and Microvascular Function
Status: RECRUITING
Conditions: Estrogen|Cardiovascular Diseases|Microvasculature
Interventions: DRUG: Nω-nitro-L-arginine methyl ester (L-NAME)|DRUG: Acetylcholine|DRUG: Sodium Nitroprusside
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Safety and Efficacy of the 2-lead OPTIMIZER® Smart System
Status: COMPLETED
Conditions: Heart Failure|Congestive Heart Failure|Chronic Heart Disease|CHF
Interventions: DEVICE: Optimizer Smart System with 2-leads
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Silent Cerebrovascular Lesion and Cognitive Decline Prevention by Cholesterol Lowering in Elderly AF Patients
Status: COMPLETED
Conditions: Atrial Fibrillation|Neuropsychology|Magnetic Resonance Imaging|Inflammation|Hemostasis
Interventions: DRUG: Atorvastatin|DRUG: ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Ph2 Nab-paclitaxel With Gemcitabine to Determine Efficacy in Advanced Non-squamous NSCLC.
Status: WITHDRAWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Nab-paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plasma of Argon Cleaning on Implant Abutments: 5-year Results of a Randomized Clinical Trial
Status: COMPLETED
Conditions: Endosseous Dental Implant Failure|Alveolar Bone Loss
Interventions: DEVICE: Steam clean|DEVICE: Plasma of Argon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of a Fermented Dairy Product on Gastrointestinal Well Being in Adult Women
Status: COMPLETED
Conditions: Healthy Adult Women
Interventions: OTHER: 1-Fermented Probiotic Dairy Product (test)|OTHER: 2-Milk-based non-fermented dairy product(control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence Study of Perindopril Tablets in Healthy Volunteers Under Fasting Conditions
Status: RECRUITING
Conditions: Bioequivalence
Interventions: DRUG: Perindopril tablet|DRUG: Prestarium® A tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of GWP42006 in People With Focal Seizures - Part B
Status: COMPLETED
Conditions: Epilepsy|Focal Seizures
Interventions: DRUG: GWP42006|DRUG: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Coblation Channeling Treatment for Chronic Tonsillitis.
Status: UNKNOWN
Conditions: Chronic Tonsillitis
Interventions: DEVICE: Arthrocare® Corporation (ArthroCare Corporation, 7500 Rialto Boulevard Austin, Texas 78735) COBLATION electrode ReFlex Ultra 55*|PROCEDURE: tonsillectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Drug Monitoring of Tocilizumab in Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Tocilizumab
Interventions: DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fitness for Brain Optimization for Late-Life Depression
Status: RECRUITING
Conditions: Depression in Old Age
Interventions: OTHER: On-site AE|OTHER: At-home AE|OTHER: Social Engagement (SE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bioequivalence Study of Atorvastatin Calcium Tablets, 40 mg of Dr. Reddy's Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Atorvastatin Calcium Tablets, 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Polypodium Leucotomos Extract Decreasing UVA Premutagenic and Photoaging Markers
Status: COMPLETED
Conditions: Aging|Skin Abnormalities
Interventions: DRUG: Polypodium leucotomos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Climate Friendly and Ecological Food on Microbiota
Status: COMPLETED
Conditions: Sustainability|Microbiota|Pesticides|Organic Food
Interventions: OTHER: Climate friendly diet|OTHER: Organic diet|OTHER: Climate friendly and organic diet|OTHER: Control group (Control diet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: GSK1120212 Rollover Study
Status: TERMINATED
Conditions: Cancer
Interventions: DRUG: GSK1120212|DRUG: Docetaxel + GSK1120212|DRUG: Erlotinib + GSK1120212|DRUG: Pemetrexed + GSK1120212|DRUG: Carboplatin + GSK1120212|DRUG: Nab-paclitaxel + GSK1120212|DRUG: Gemcitabine + GSK1120212|DRUG: Everolimus + GSK1120212
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Albumin to Reduce Inflammation Following Surgery
Status: TERMINATED
Conditions: Systemic Inflammatory Response Syndrome|Cardiopulmonary Bypass
Interventions: DRUG: 20% Human albumin solution|DRUG: Gelofusin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity of Concomitant Administration of COVID-19 Vaccines With Influenza Vaccines
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19|Influenza|Vaccine Reaction|Contaminant Injected
Interventions: BIOLOGICAL: Omicron-containing COVID-19 vaccine|BIOLOGICAL: influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Asthma Control in Elderly Patients With Montelukast
Status: COMPLETED
Conditions: Persistent Asthma|Elderly
Interventions: DRUG: Combination of low ICS and montelukast|DRUG: Monotherapy of medium dose ICS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Characterize Absorption, Distribution, Metabolism and Excretion of 14C PF-06651600 and to Evaluate the Absolute Oral Bioavailability and Fraction Absorbed of PF-06651600.
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: 14C-PF-06651600|DRUG: 14C-PF-06651600 IV|DRUG: PF-06651600
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dexmedetomidine in the Treatment of Agitation Associated With Schizophrenia and Bipolar Disorder (SERENITY III)
Status: ACTIVE_NOT_RECRUITING
Conditions: Agitation,Psychomotor|Bipolar I Disorder|Bipolar II Disorder|Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorders
Interventions: DRUG: BXCL501|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Pioglitazone in the Treatment of Non-alcoholic Steatohepatitis (NASH)
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis
Interventions: DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Human Spinal Cord-derived Neural Stem Cell Transplantation for the Treatment of Chronic SCI
Status: UNKNOWN
Conditions: Spinal Cord Injury (SCI)
Interventions: DRUG: Human spinal cord stem cells.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metabolic Effects of Antihypertensive Drugs on People With Metabolic Syndrome (The MEAD Study)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Hydrochlorothiazide|DRUG: Trandolapril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Safety, Tolerability and Efficacy of 1% GPB Cream Versus Qbrexza® (Glycopyrronium) Cloth 2.4% Under Maximum-Use Conditions in Subjects With Primary Axillary Hyperhidrosis
Status: UNKNOWN
Conditions: Primary Axillary Hyperhidrosis
Interventions: DRUG: WO3970|DRUG: Qbrexza® (glycopyrronium) cloth, 2.4%, for topical use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IVICA: Intravenous Iron in Colorectal Cancer Associated Anaemia
Status: COMPLETED
Conditions: Anemia|Colorectal Neoplasm
Interventions: DRUG: Ferric carboxymaltose|DRUG: Ferrous Sulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Balloon Pulmonary Angioplasty vs. Combined Approach With Pulmonary Artery Denervation in CTEPH: Effectiveness Comparison
Status: ENROLLING_BY_INVITATION
Conditions: Chronic Thromboembolic Pulmonary Hypertension
Interventions: PROCEDURE: Balloon Pulmonary Angioplasty combined with Pulmonary Artery Denervation|PROCEDURE: Balloon Pulmonary Angioplasty with Sham Pulmonary Artery Denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Long-Duration Spaceflight on General and Spatial Cognition and Its Neural Basis
Status: ENROLLING_BY_INVITATION
Conditions: Brain Structure|Cognitive Performance
Interventions: OTHER: Spaceflight|OTHER: Controls
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Plant Exosomes +/- Curcumin to Abrogate Symptoms of Inflammatory Bowel Disease
Status: COMPLETED
Conditions: Irritable Bowel Disease
Interventions: PROCEDURE: Sigmoidoscopy and biopsy, blood work
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Smartphone-assisted Coaching System to Improve Glucose Homeostasis in Adults With Prediabetes
Status: COMPLETED
Conditions: Prediabetes|Hyperglycemia|Postprandial Hyperglycemia|Impaired Glucose Tolerance|Impaired Fasting Glucose
Interventions: OTHER: Sweetch App + DBWS|OTHER: Sweetch App Alone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Optimizing Treatment of PegIFN Alfa in HBeAg-negative CHB Patients With Low Level HBsAg
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: peginterferon alfa|DRUG: Nucleoside analogues
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Assessment of Viscosupplementation With Polynucleotides and Hyaluronic Acid
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: Polynucleotide - PNHA - Newart|DEVICE: Hyaluronic acid - HA - Ialart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Translational and Neurocomputational Evaluation of a Dopamine Receptor 1 Partial Agonist for Schizophrenia
Status: ACTIVE_NOT_RECRUITING
Conditions: Early Course Schizophrenia Spectrum Disorder
Interventions: DRUG: CVL-562 (PF-06412562) 1 mg|DRUG: CVL-562 (PF-06412562) 4 mg|DRUG: CVL-562 (PF-06412562) 15 mg|DRUG: CVL-562 (PF-06412562) 25 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial of N-Acetylcysteine (an Over-the-Counter Medicine) in Adolescents Who Smoke Marijuana
Status: COMPLETED
Conditions: Cannabis Dependence
Interventions: DRUG: N-Acetylcysteine|DRUG: placebo|BEHAVIORAL: Contingency Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Circulating Endothelial Cell as Marker for Avastin (Bevacizumab) in Combination With Docetaxel Plus Xeloda (Capecitabine) as First Line Treatment for Patients With Locally Recurrent and Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: bevacizumab [Avastin]|DRUG: capecitabine [Xeloda]|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Pharmacodynamic Bioequivalence Study of Beclomethasone Dipropionate 40 mcg INH
Status: COMPLETED
Conditions: Bronchial Asthma
Interventions: DRUG: Test Product|DRUG: Reference Product|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Quietude Study: Quetiapine Use for Agitated Depression
Status: TERMINATED
Conditions: Depression With Prominent Agitation
Interventions: DRUG: Quetiapine XR|DRUG: Escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Individually Timed Stair Climbing and Descending to Lower Postprandial Glucose
Status: COMPLETED
Conditions: Postprandial Hyperglycemia|Postprandial Insulin
Interventions: OTHER: Stair climbing and descending for 1 minute|OTHER: Stair climbing and descending for 3 minutes|OTHER: Seated control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Matrix Metalloproteinases After Surgery and/or Radiofrequency Ablation in Patients With Liver Metastases From Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Metastatic Cancer
Interventions: OTHER: laboratory biomarker analysis|PROCEDURE: cryosurgery|PROCEDURE: radiofrequency ablation|PROCEDURE: therapeutic conventional surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ofatumumab, Pentostatin, and Cyclophosphamide in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Stage 0 Chronic Lymphocytic Leukemia|Stage I Chronic Lymphocytic Leukemia|Stage I Small Lymphocytic Lymphoma|Stage II Chronic Lymphocytic Leukemia|Stage II Small Lymphocytic Lymphoma|Stage III Chronic Lymphocytic Leukemia|Stage III Small Lymphocytic Lymphoma|Stage IV Chronic Lymphocytic Leukemia|Stage IV Small Lymphocytic Lymphoma
Interventions: DRUG: Cyclophosphamide|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Ofatumumab|DRUG: Pentostatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Treatment With Nivolumab and Trabectedin in Patients With Metastatic or Inoperable Soft Tissue Sarcomas
Status: COMPLETED
Conditions: Metastatic Adult Soft Tissue Sarcoma
Interventions: DRUG: Trabectedin|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep and Immunity in Rheumatoid Arthritis : Remicade Substudy
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Remicade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Maternal Epidural Steroids and Hyperthemia
Status: TERMINATED
Conditions: Fever|Labor Pain|Complication of Anesthesia During Pregnancy, Unspecified
Interventions: DRUG: Methylprednisolone|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Supplementation to ADHD Medication in Children
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder|Deficient Emotional Self-Regulation
Interventions: DIETARY_SUPPLEMENT: Omega-3 Fatty Acid|DRUG: ADHD Medication
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Synbiotic on Composition of Human Gut Microbiota and Production of Short and Branched-chain Fatty Acids
Status: COMPLETED
Conditions: Synbiotics|Healthy Humans|Composition of Gut Microbiota|Short and Branched-chain Fatty Acids
Interventions: DIETARY_SUPPLEMENT: Combination of Lactobacillus acidophilus NCFM and cellobiose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial to Strengthen Existential Resiliency Among Women With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms|Neoplasm Metastasis
Interventions: OTHER: Growing Resiliency And CouragE with Cancer™ (GRACE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Pharmacokinetics of IGSC 20% in Subjects With Primary Immunodeficiency
Status: COMPLETED
Conditions: Primary Immunodeficiency
Interventions: BIOLOGICAL: IGIV-C 10%|BIOLOGICAL: IGSC 20%
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Possible Therapeutic Role for Adenosine During Inflammation
Status: COMPLETED
Conditions: Endotoxemia
Interventions: GENETIC: AMPD1 polymorphism|DRUG: Caffeine infusion|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Attachment Systems for Implant Overdenture
Status: COMPLETED
Conditions: Dental Implants|Dental Prosthesis Failure
Interventions: DEVICE: OT Equators® (Rhein83)|DEVICE: Locator® (Zest)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Handling Medium for ICSI With Ionomycin and Latrunculin A
Status: COMPLETED
Conditions: Infertility
Interventions: OTHER: Doing ICSI I a medium supplemented with Ionomycin and Latrunculin A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Trial Of PF-04856884 In Patients With Recurrent Glioblastoma
Status: WITHDRAWN
Conditions: Glioblastoma
Interventions: BIOLOGICAL: PF-04856884|BIOLOGICAL: PF-04856884
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nebulized Heparin for the Treatment of COVID-19 Induced Lung Injury
Status: TERMINATED
Conditions: Covid-19|ARDS, Human|Acute Lung Injury
Interventions: DRUG: Heparin|DRUG: 0.9% Sodium-chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients
Status: TERMINATED
Conditions: Depression|PCOS
Interventions: DIETARY_SUPPLEMENT: Inositol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Two-part Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of KRP203 in Patients Undergoing Stem Cell Transplant for Hematological Malignancies
Status: COMPLETED
Conditions: Hematological Malignancies
Interventions: DRUG: Study Part 1: KRP203|DRUG: Study Part 2: KRP203 lower dose|DRUG: Study Part 2: KRP203 higher dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Low-chlorine Vs High-chlorine Crystalloids in Septic Shock Adults
Status: UNKNOWN
Conditions: Septic Shock
Interventions: DRUG: Sodium Bicarbonate Ringer's Injection|DRUG: 0.9% Sodium Chloride Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DDX3X Syndrome -The Seaver Autism Center for Research and Treatment is Characterizing DDX3X-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures.
Status: RECRUITING
Conditions: DDX3X|Mental Retardation, X-linked 102|Autism Spectrum Disorder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Pharmacokinetic and Safety of NVP-1705 and NVP-1705-R in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: NVP-1705|DRUG: NVP-1705-R
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Lipiodol/Ethanol With Drug-eluting Beads (DEB) for Hepatocellular Carcinoma
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Drug-Eluting Beads (DEB) with Doxorubicin|DRUG: Lipiodol Ethanol Mixture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel, Folic Acid, and Lometrexol in Treating Patients With Locally Advanced or Metastatic Solid Tumors
Status: UNKNOWN
Conditions: Drug/Agent Toxicity by Tissue/Organ|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DIETARY_SUPPLEMENT: folic acid|DRUG: lometrexol|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Azelaic Acid Foam 15% in the Treatment of Papulopustular Rosacea
Status: COMPLETED
Conditions: Rosacea, Papulopustular
Interventions: DRUG: Azelaic Acid foam 15%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Early Aggressive Rheumatoid Arthritis (TEAR)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: methotrexate|DRUG: sulfasalazine|DRUG: hydroxychloroquine|DRUG: etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of Somatosensory Rehabilitation of Pain by Vibrotactile Stimulation on Static Mechanical Allodynia
Status: COMPLETED
Conditions: Allodynia
Interventions: OTHER: Standard Medical treatment|DEVICE: Vibrotactile stimulation|DEVICE: Sham Stimulation with Vibradol device switched off
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mood Effects of Serotonin Agonists Extended
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Placebo|DRUG: Serotonin agonist - 13ug|DRUG: Serotonin agonist - 26ug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Efficacy of 125I Brachytherapy Combined With Anlotinib in Radioiodine Refractory Thyroid Carcinoma Patients
Status: COMPLETED
Conditions: Thyroid Neoplasms
Interventions: COMBINATION_PRODUCT: Iodine-125 brachytherapy combine with Anlotinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparing the Effectiveness of 2 Diets for Patients With Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: OTHER: Dietary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Pulse Radiofrequency Treatment for Subacromial Impingement Syndrome
Status: COMPLETED
Conditions: Shoulder Impingement Syndrome
Interventions: DEVICE: Transcutaneous pulse radiofrequency therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Medicine-induced Cardiac Hemodialysis on COVID-19
Status: COMPLETED
Conditions: Severe Acute Respiratory Syndrome-related Coronavirus|Renal Dialysis|Vaccines|Myocarditis Allergic|Infection Viral
Interventions: DRUG: Nifedipine 30 MG|DIAGNOSTIC_TEST: Kangzhu BPCB0A-3A|BEHAVIORAL: Low Mobility|DRUG: Enalapril Maleate 10Mg Tab|DRUG: Lansoprazole 30Mg Ec Cap|DRUG: Metoprolol Succinate|DIETARY_SUPPLEMENT: Coenzyme Q10|DIETARY_SUPPLEMENT: d-alpha tocopherol acetate|DIETARY_SUPPLEMENT: Omega-3|DRUG: Duloxetine Hydrochloride 20 MG Oral Capsule, Delayed Release|DRUG: Superoxide Dismutase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long Term Outcome of Combined Phacoemulsification and Excisional Goniotomy With the Kahook Dual Blade
Status: COMPLETED
Conditions: Glaucoma|Glaucoma, Open-Angle|Cataract|Angle Closure Glaucoma|Surgery
Interventions: DEVICE: kahook dual blade
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FOLFIRI as Salvage Treatment in Metastatic Biliary Tract Cancer (BTC) Patients Who Were Failed After Gemcitabine Containing Chemotherapy: A Phase II Single Arm Prospective Study
Status: WITHDRAWN
Conditions: Biliary Tract Cancer
Interventions: DRUG: Fluorouracil|DRUG: Irinotecan Hydrochloride|DRUG: leucovorin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Manual Therapy Based on the Fascial Distortion Model in Individuals With Temporomandibular Disorder
Status: COMPLETED
Conditions: Temporomandibular Disorder|Temporomandibular Joint Dysfunction Syndrome|Temporomandibular Joint Disorders|Temporomandibular Joint Pain|Temporomandibular Joint Disc Displacement|Manual Therapy
Interventions: PROCEDURE: Fascial Distortion Model|PROCEDURE: Core Stabilization Training|PROCEDURE: Rocabado's 6x6 Exercises|BEHAVIORAL: Patient Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy, Safety, Tolerability and Pharmacokinetics of MIJ821 in Participants With Treatment- Resistant Depression (TRD)
Status: COMPLETED
Conditions: Treatment-Resistant Depression
Interventions: DRUG: MIJ821 Subcutaneous Injection - low dose|DRUG: MIJ821 Subcutaneous Injection - medium dose|DRUG: MIJ821 Subcutaneous Injection - high dose|DRUG: Placebo Subcutaneous Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Nafamostat Mesilate for Anticoagulation in Patients With ECMO
Status: NOT_YET_RECRUITING
Conditions: Extracorporeal Membrane Oxygenation Complication
Interventions: DRUG: nafamostat mesilate|DRUG: unfractionated heparin group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Rocuronium Onset Time According to Remifentanil Infusion
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: the order of drug administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: OSI-774/Cisplatin/Taxotere in Head & Neck Squamous Cell Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer
Interventions: DRUG: Docetaxel|DRUG: OSI-774|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Daily Oral L-arginine Plus Tadalafil in Diabetic Patients With Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: L-arginine 5 gm oral caps|DRUG: Tadalafil 10 MG|DIAGNOSTIC_TEST: serum testosterone level|DIAGNOSTIC_TEST: HbA1C|DEVICE: penile doppler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Escalating Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of LNK 754 in Elderly Volunteers and in Subjects With Mild Alzheimer's Disease
Status: COMPLETED
Conditions: Mild Alzheimer's Disease
Interventions: DRUG: LNK-754|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Safety, Tolerability and Preliminary Efficacy of Lenodiar Pediatric in Diarrhea
Status: UNKNOWN
Conditions: Diarrhea|Chronic Diarrhea|Acute Diarrhea|Diarrhea, Infantile
Interventions: DEVICE: Actitan-F (7dd)|DEVICE: Actitan-F (28dd)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HEALEY ALS Platform Trial - Regimen B Verdiperstat
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Matching Placebo|DRUG: Verdiperstat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Repeated Doses of PF-04958242 in Healthy Volunteers
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: PF-04958242|DRUG: PF-04958242|DRUG: PF-04958242|DRUG: PF-04958242|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 1b Study to Evaluate APL-1401 in Patients With Moderately to Severely Active Ulcerative Colitis
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: APL-1401|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ruxolitinib and Pomalidomide Combination Therapy in Patients With Primary and Secondary MF
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Myelofibrosis|Secondary Myelofibrosis|PMF|SMF|Post-PV MF|Post-ET MF
Interventions: DRUG: INCB018424/CC-4047
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupoint Electric Stimulation Combined With Tropisetron in Preventing and Treating Nausea and Vomiting After TACE
Status: UNKNOWN
Conditions: Nausea|Vomiting|Metastatic Liver Cancer
Interventions: DEVICE: acupoint electric stimulation|DRUG: tropisetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study Evaluating the Effects of Siltuximab on the Heart in Patients With Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma, or Indolent Multiple Myeloma
Status: COMPLETED
Conditions: Monoclonal Gammopathy of Undetermined Significance|Multiple Myeloma|Plasma Cell Neoplasm
Interventions: BIOLOGICAL: Siltuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT