pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: An Open-label Drug-Drug Interaction Study to Evaluate the Effect of BCX7353 on Cytochrome P450 Enzyme Activity Using Probe Substrates
Status: COMPLETED
Conditions: Hereditary Angioedema
Interventions: DRUG: BCX7353 and probes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Healthy Eating Attitudes and Behaviours Group Program
Status: COMPLETED
Conditions: Eating Disorders|Body Image Disturbance
Interventions: BEHAVIORAL: Healthy Eating Attitudes and Behaviours Group Program (Experimental Group Condition)|BEHAVIORAL: Eating Disorders and Body Dissatisfaction: A Group Work (Active Control Group Condition)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Single-dose Crossover Study to Compare the Safety and Efficacy of FlutiForm With Fluticasone and Formoterol Concurrently or Alone in Asthma Patients
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: fluticasone propionate, formoterol fumarate|DRUG: fluticasone propionate, formoterol fumarate|DRUG: fluticasone propionate, formoterol fumarate|DRUG: fluticasone propionate, formoterol fumarate|DRUG: fluticasone propionate, formoterol fumarate|DRUG: fluticasone propionate, formoterol fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Fibrin Sealant Vapor Heated Solvent/Detergent Treated (FS VH S/D) for Hemostasis in Subjects Undergoing Total Hip Replacement
Status: COMPLETED
Conditions: Hip Replacement Surgery
Interventions: DRUG: Fibrin Sealant Vapor-Heated Solvent/Detergent-treated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test How Well BI 3720931 is Tolerated and Whether it Improves Lung Function in People With Cystic Fibrosis (Lenticlair™ 1)
Status: NOT_YET_RECRUITING
Conditions: Cystic Fibrosis
Interventions: GENETIC: BI 3720931|DRUG: Placebo|DEVICE: Inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chlorhexidine Versus Povidone-Iodine for Prevention of Epidural Needle Contamination in the Parturient
Status: COMPLETED
Conditions: Asepsis|Analgesia, Epidural|Anesthesia, Epidural
Interventions: DRUG: Chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of an EMDR Intervention on Traumatic and Obsessive Symptoms
Status: COMPLETED
Conditions: Adult ALL|Post-traumatic Stress Disorder|Obsessive-Compulsive Disorder|Disgust|Guilt|Shame
Interventions: BEHAVIORAL: EMDR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Capecitabine Plus Pyrotinib Versus Capecitabine Plus Trastuzumab and Pertuzumab in the First-line Treatment of HER2-positive Metastatic Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Capecitabine and Pyrotinib|DRUG: Capecitabine,Trastuzumab, and Pertuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proxalutamide Treatment for Hospitalized COVID-19 Patients
Status: COMPLETED
Conditions: Covid19|SARS (Severe Acute Respiratory Syndrome)
Interventions: DRUG: Proxalutamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: 18F-FLT Positron Emission Tomography and Diffusion-Weighted Magnetic Resonance Imaging in Planning Surgery and Radiation Therapy and Measuring Response in Patients With Newly Diagnosed Ewing Sarcoma
Status: COMPLETED
Conditions: Adult Supratentorial Primitive Neuroectodermal Tumor (PNET)|Ewing Sarcoma of Bone|Extraosseous Ewing Sarcoma|Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor
Interventions: DRUG: fluorine F 18 fluorothymidine|RADIATION: fludeoxyglucose F 18|PROCEDURE: positron emission tomography|PROCEDURE: diffusion-weighted magnetic resonance imaging|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Supportive Versus Immunosuppressive Therapy for the Treatment Of Progressive IgA Nephropathy
Status: COMPLETED
Conditions: IgA Nephropathy
Interventions: DRUG: supportive therapy with: ACE-inhibitor / ARB / Statin|DRUG: supportive and immunosuppressive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Confirmatory Study of NeoCart in Knee Cartilage Repair
Status: TERMINATED
Conditions: Articular Cartilage Defects in the Knee Joint
Interventions: BIOLOGICAL: NeoCart|PROCEDURE: Microfracture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinician Managed Interpersonal Psychotherapy
Status: COMPLETED
Conditions: Depression|Depression, Postpartum
Interventions: BEHAVIORAL: Standard interpersonal psychotherapy (IPT)|BEHAVIORAL: Clinician managed interpersonal psychotherapy (CM-IPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin in Esophagus Cancer (Advanced) 1st Line
Status: COMPLETED
Conditions: Esophageal Neoplasms
Interventions: DRUG: Oxaliplatin + cisplatin + 5-Fluorouracil (5-FU)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D3 Supplementation in Treatment of Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Vitamin D3 (Cholecalciferol)|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single-Dose Study of MK-8351 in a Lung Allergen Challenge (MK-8351-003)
Status: WITHDRAWN
Conditions: Asthma
Interventions: DRUG: Low-Dose MK-8351|DRUG: High-Dose MK-8351|DRUG: Placebo to MK-8351
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Infusion of Cell Populations From Unlicensed Umbilical Cord Blood Units
Status: RECRUITING
Conditions: Lymphatic Diseases|Hematopoietic Malignancy
Interventions: BIOLOGICAL: Umbilical Cord Blood (UCB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of Educating Physical Therapists in the Treatment of Patients With Nonspecific Chronic Low Back Pain
Status: WITHDRAWN
Conditions: Back Pain
Interventions: OTHER: Control|OTHER: Trained
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implications of Fecal Microbiota Transplantation in Modulating the Effects of Liver Cirrhosis
Status: RECRUITING
Conditions: Liver Cirrhosis
Interventions: BIOLOGICAL: Fecal microbiota transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thrombectomy Revascularization of Intracranial Vessel OcclusioN by Originating From Japan (TRON1-Japan)
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: DEVICE: Thrombectomy Device T-01
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: International Cancer of the Head and Neck, Genetics and Environment (InterCHANGE) Study
Status: UNKNOWN
Conditions: Evaluate the Association Between Certain Environmental Exposures (e.g. Cigarette Smoking, Alcohol Drinking, Betel Nut Chewing…) and Head and Neck Cancers|Assess the Effect of Genetic Factors, Including Both SNP and Copy Number Variation (CNV) Through Analysis of Both Main Effect and Gene-gene Interaction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Transcranial Alternative Current Stimulation at Alpha Frequency (α-tACS) on Stressed Healthy Subjects
Status: RECRUITING
Conditions: Healthy
Interventions: PROCEDURE: Transcranial alternative current stimulation (tACS) at alpha frequency|PROCEDURE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Epinephrine Vs Norepinephrine Infusion During Caesarean Delivery
Status: NOT_YET_RECRUITING
Conditions: Hypotension|Spinal Block|Cesarean Section
Interventions: DRUG: Norepinephrine|DRUG: Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of SANGUINATE™ for Reduction of Delayed Graft Function in Patients Receiving a Kidney Transplant
Status: COMPLETED
Conditions: Delayed Function of Renal Transplant
Interventions: DRUG: SANGUINATE|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Different Antibiotic Protocols on Peri-implant Tissue Health
Status: NOT_YET_RECRUITING
Conditions: Antibiotic
Interventions: DRUG: Amoxicillin Short|DRUG: Amoxicillin Long
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Split Wound Comparison of Trichophytic Closure Techniques for Donor Site in Hair Transplantation
Status: UNKNOWN
Conditions: Androgenetic Alopecia
Interventions: PROCEDURE: Trichophytic closure upper edge trimming|PROCEDURE: Trichophytic closure lower edge trimming|PROCEDURE: Trichophytic closure both edge trimming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Triheptanoin for the Prevention of Hypoglycemia in Patients With Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCADD)
Status: RECRUITING
Conditions: Medium-chain Acyl-CoA Dehydrogenase Deficiency
Interventions: DRUG: Triheptanoin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: C-MAC Videolaryngoscope Intubation and Cervical Spine Motion
Status: UNKNOWN
Conditions: Intubation;Difficult|Cervical Spinal Cord Injury
Interventions: DEVICE: C-MAC videolaryngoscope intubation|DEVICE: Direct laryngoscope intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: HF2 Therapy in the Treatment of Active Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DIETARY_SUPPLEMENT: HF2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Balloon Assisted Transarterial Therapy for Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: The balloon catheter is placed at the various arterial feeders of the tumor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemoadsorption for Prevention of Vasodilatory Shock in Cardiac Surgery Patients With Infective Endocarditis
Status: COMPLETED
Conditions: Infective Endocarditis
Interventions: DEVICE: hemoadsorber for removal of cytokines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetic and Metabolism of [14^C] BMS-986177 in Healthy Male Participants
Status: COMPLETED
Conditions: Thrombosis
Interventions: DRUG: BMS-986177
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Temporary Inactivation of Strong Muscle Sensation to Improve Rehabilitation Interventions in SCI
Status: RECRUITING
Conditions: Spinal Cord Injuries|Spine Disease|Stroke
Interventions: DRUG: Lidocaine Cream 5%|OTHER: Rehabilitation Movement Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VOIES-D-ql - Qualitative Study on Experiences of Diabetes Care Delivery and Planning
Status: COMPLETED
Conditions: Diabete Type 1|Diabete Type 2
Interventions: OTHER: Description of patients' experiences of diabetes care delivery and planning|OTHER: Description of health care professionals needs and experiences in diabetes care delivery and planning
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neoadjuvant-Adjuvant Pembrolizumab in Resectable Advanced Basal Cell Carcinoma of H&N
Status: ACTIVE_NOT_RECRUITING
Conditions: Basal Cell Carcinoma of the Head and Neck
Interventions: DRUG: Pembrolizumab|OTHER: Tissue collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety and Efficacy of AT13387, Alone or in Combination With Imatinib, in Patients With GIST
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumor (GIST)
Interventions: DRUG: AT13387 and Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Improve Detection and Early Recurrence Rate in Bladder Cancer Patients Using Hexvix Fluorescence Cystoscopy
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: Hexvix|PROCEDURE: Standard white light cystoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Moringa Oleifera Leaves on Glycemic Control of Women With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Supplementation of Moringa oleifera leaf powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of PEG-400 and Systane Artificial Tears (Alcon) on Quality of Vision
Status: COMPLETED
Conditions: Myopia
Interventions: DRUG: PEG-400|DRUG: Systane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Trial Comparing Microdebrider-Assisted Inferior Turbinoplasty (MAIT) vs Submucous Resection (SMR)
Status: TERMINATED
Conditions: Nasal Obstruction
Interventions: PROCEDURE: Microdebrider-Assisted Inferior Turbinoplasty (MAIT)|PROCEDURE: Submucous Resection with non powered instrument
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Efficacy and Safety of the LentiGlobin® BB305 Drug Product in Participants With Transfusion-Dependent β-Thalassemia, Who do Not Have a β0/β0 Genotype
Status: COMPLETED
Conditions: Beta-Thalassemia
Interventions: GENETIC: LentiGlobin BB305 Drug Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot, Open-Label Study of Luspatercept for Patients With Lower Risk Myelodysplastic Syndromes (MDS)
Status: RECRUITING
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Luspatercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunological Effects of Two Mistletoe Preparations in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: mistletoe preparations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Effect of Chosen Treatment Methods in Patients With Cervical Spine Osteoarthritis
Status: COMPLETED
Conditions: Cervical Spine Osteophyte
Interventions: OTHER: PNF group|OTHER: manual therapy group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Baricitinib in the Post-intracerebral Hemorrhage Pulmonary Injury
Status: RECRUITING
Conditions: Pulmonary Injury After Intracerebral Hemorrhage
Interventions: DRUG: Baricitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: OT and Social Cognition in Children With ADHD: Impact of MPH
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Ritalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy Study of Daptomycin in Pediatric Participants (1 to 17 Years-old) With Skin and Skin Structure Infections
Status: COMPLETED
Conditions: Skin Diseases, Infectious
Interventions: DRUG: Daptomycin|DRUG: Standard of Care (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pirfenidone in Children and Young Adults With Neurofibromatosis Type I and Progressive Plexiform Neurofibromas
Status: COMPLETED
Conditions: Neurofibromatosis 1|Neurofibroma, Plexiform
Interventions: DRUG: Pirfenidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Nab-paclitaxel-based Doublet as First Line Therapy in Patients With Cancer of Unknown Primary (CUP)
Status: COMPLETED
Conditions: Unknown Primary Tumors
Interventions: DRUG: nab-paclitaxel|DRUG: Carboplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determine the Safety and Efficacy of (R,R)-Formoterol in the Treatment of Subjects With COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Chronic Bronchitis|Emphysema
Interventions: DRUG: arformoterol tartrate inhalation solution|DRUG: arformoterol tartrate inhalation solution|DRUG: arformoterol tartrate inhalation solution|DRUG: Salmeterol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RAS Quantification in Patients With Aliskiren or Candesartan
Status: COMPLETED
Conditions: Hypertension|Chronic Kidney Disease|Proteinuria
Interventions: OTHER: RAS blockade discontinuation|DRUG: Aliskiren|DRUG: Candesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Examine National Characteristics & Outcome Measures of GERD Patients Using the PPI Acid Suppression Symptom (PASS) Test for Response
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: T Cell Therapy of Opportunistic Cytomegalovirus Infection
Status: RECRUITING
Conditions: Cytomegalovirus Infections|Hematopoietic Stem Cell Transplant|Opportunistic Infections
Interventions: BIOLOGICAL: CMV specific adoptive t-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of RAD001 in Breast Cancer Patients With Bone Metastases
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: RAD001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Targeting High Risk Populations With Enhanced Reactive Focal Mass Drug Administration in Thailand
Status: UNKNOWN
Conditions: Plasmodium Falciparum Malaria|Plasmodium Vivax Malaria
Interventions: OTHER: Case Management and Follow-up|OTHER: Reactive focal mass drug administration (rfMDA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Phase II Study on Immunogenicity and Safety of MVA-BN® (IMVAMUNE™) Smallpox Vaccine in Subjects With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: BIOLOGICAL: IMVAMUNE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy, Radiation Therapy, and RSR13 in Treating Patients With Stage III Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: chemotherapy|DRUG: efaproxiral|DRUG: paclitaxel|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Experimentally Testing the Effectiveness of a Campus-based Bystander Intervention
Status: COMPLETED
Conditions: Assaultive Behavior|Violence|Sexual Assault and Rape|Helping Behavior
Interventions: BEHAVIORAL: SCREAM Theater Dose 1|BEHAVIORAL: SCREAM Theater Doses 2 & SCREAM Theater Dose 3|BEHAVIORAL: SCREAM Theater Dose 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sorafenib in Treating Patients With Metastatic, Locally Advanced, or Recurrent Sarcoma
Status: COMPLETED
Conditions: Adult Angiosarcoma|Adult Epithelioid Sarcoma|Adult Leiomyosarcoma|Adult Malignant Fibrous Histiocytoma|Adult Neurofibrosarcoma|Adult Synovial Sarcoma|Ovarian Sarcoma|Recurrent Adult Soft Tissue Sarcoma|Recurrent Uterine Sarcoma|Stage III Adult Soft Tissue Sarcoma|Stage III Uterine Sarcoma|Stage IV Adult Soft Tissue Sarcoma|Stage IV Uterine Sarcoma|Uterine Carcinosarcoma|Uterine Leiomyosarcoma
Interventions: DRUG: sorafenib tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety, Tolerability and Pharmacokinetic Study of HEC585 in Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: HEC585
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peer-Driven Intervention for Sleep Apnea
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea
Interventions: OTHER: Usual Care|OTHER: Peer-Buddy System|OTHER: Usual Care|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Accuracy of Dexcom G6® and FreeStyle Libre® Sensors in Standardized Hypoxemia Conditions
Status: UNKNOWN
Conditions: Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus
Interventions: PROCEDURE: acute hypoxia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of Pressure Biofeedback Therapy and Progressive Muscle Relaxation Technique in Improving Pain and Disability Among Patients With Non-Specific Low Back Pain
Status: RECRUITING
Conditions: Low Back Pain, Mechanical|Chronic Low-back Pain|Mechanical Low Back Pain|Lower Back Pain Chronic|Low Back Pain|CLBP - Chronic Low Back Pain|Pain, Chronic|Pain, Back
Interventions: OTHER: Pressure Biofeedback Therapy + Progressive Muscles Relaxation + thermotherapy|OTHER: Progressive Muscles Relaxation + thermotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Paclitaxel-eluting Balloon for Treatment of Lesions in Native Small Coronary Arteries
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: SeQuent® Please Drug-eluting balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluids in Septic Shock (FISSH)
Status: RECRUITING
Conditions: Sepsis, Septic Shock
Interventions: OTHER: higher chloride crystalloid|OTHER: lower chloride crystalloid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pediatric Emergency Suture Care: a Trial Comparing the Analgesic Efficacy of Hypnosis Versus MEOPA
Status: RECRUITING
Conditions: Wounds, Nonpenetrating
Interventions: DRUG: Use of MEOPA during suturing|OTHER: Use of Hypnosis during suturing|PROCEDURE: Stitch removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Structured Physical Activity Education Delivery in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Physical activity and exercise education and behaviour counseling from a Registered Kinesiologist and a YMCA Wellness Coach|BEHAVIORAL: Unstructured Physical Activity and Exercise Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation of Nudges to Promote Utilization of Low Tidal Volume Ventilation (INPUT) Study
Status: COMPLETED
Conditions: ARDS|Critical Illness|Acute Respiratory Distress Syndrome|Acute Respiratory Failure
Interventions: BEHAVIORAL: RT-targeted accountable justification|BEHAVIORAL: Default order set|BEHAVIORAL: physician-targeted accountable justification|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Multicenter Study Comparing the Efficacy and Safety of OROS Methylphenidate HCl, Ritalin (Methylphenidate HCl) and Placebo in Children With Attention Deficit Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: OROS methylphenidate HCl|DRUG: Ritalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Testing the Safety of Adding Either Monalizumab (IPH2201) or Oleclumab (MEDI9447) to Durvalumab (MEDI4736) Plus Standard Radiation Therapy for Locally Advanced Non-small Cell Lung Cancer (NSCLC), ARCHON-1 Trial
Status: RECRUITING
Conditions: Locally Advanced Lung Non-Small Cell Carcinoma|Locally Recurrent Lung Non-Small Cell Carcinoma|Stage II Lung Cancer AJCC v8|Stage III Lung Cancer AJCC v8|Unresectable Lung Non-Small Cell Carcinoma
Interventions: RADIATION: Accelerated Hypofractionated Radiation Therapy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|BIOLOGICAL: Durvalumab|PROCEDURE: Magnetic Resonance Imaging of the Brain with and without Contrast|BIOLOGICAL: Monalizumab|BIOLOGICAL: Oleclumab|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Triple Therapy in T1DM
Status: RECRUITING
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Insulin|DRUG: Semaglutide|DRUG: Dapagliflozin|DRUG: Placebo to Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Interventions for Indoor Air -Related Functional Symptoms
Status: COMPLETED
Conditions: Environmental Illness|Functional Symptoms
Interventions: BEHAVIORAL: Cognitive-Behavioral Therapy (CBT)|BEHAVIORAL: Applied relaxation group therapy|BEHAVIORAL: Information session (psychoeducation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Efficacy of Conivaptan (Vaprisol®) to Raise Serum Sodium Levels in Patients With Severe Traumatic Brain Injury
Status: COMPLETED
Conditions: Severe Traumatic Brain Injury
Interventions: DRUG: Conivaptan (Vaprisol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study To Evaluate The Impact Of Anti-Cyclic Citrullinated Peptide(Anti-CCP) For Management With Enbrel In Patients With Psoriatic Arthritis(PsA)
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Enbrel
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Role of Oxytocin in the Second Stage of Labor
Status: RECRUITING
Conditions: Labor Complication
Interventions: DRUG: Continue Oxytocin|OTHER: Discontinue Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "COACH" Study: Individualized COaching in Young Adult Cancer Survivors to Encourage Healthy Behaviors
Status: RECRUITING
Conditions: Health Behavior
Interventions: BEHAVIORAL: Digital Diet Diary|BEHAVIORAL: NHANES Food Frequency Questionnaire (FFQ)|BEHAVIORAL: Fitbit data collection|BEHAVIORAL: Quality of Life questionnaire|BEHAVIORAL: Functional Assessment of Cancer Therapy - General (FACT-G) Questionnaire|BEHAVIORAL: Godin Exercise Leisure-Time questionnaire|BEHAVIORAL: Zoom interviews
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: School Inner-City Asthma Intervention Study (SICAS-2)
Status: COMPLETED
Conditions: Asthma
Interventions: OTHER: integrated pest management|OTHER: air purifier|OTHER: No intervention (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Modafinil vs Placebo for Treatment of Anesthesia Delayed Emergence in Obstructive Sleep Apnea
Status: TERMINATED
Conditions: Obstructive Sleep Apnea|Delayed Emergence From Anesthesia
Interventions: DRUG: Modafinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Antioxidants on Cardiovascular Risk Measures (Spice Study)
Status: COMPLETED
Conditions: Cardiovascular|Psychological Stress
Interventions: DIETARY_SUPPLEMENT: High Antioxidant Spice Blend|BEHAVIORAL: Trier Psychological Stressor|OTHER: Placebo antioxidant concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: N-3 Polyunsaturated Fatty Acids in the Prevention and Treatment for IFN-induced Depression
Status: COMPLETED
Conditions: Major Depressive Episode
Interventions: DIETARY_SUPPLEMENT: Omega-3 fatty acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Knee Extension Constraint Rehabilitation After ACL Reconstruction
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament Injuries
Interventions: DEVICE: brace1|DEVICE: brace2|OTHER: No Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate The PDE10 Enzyme Occupancy Following A Single Dose Of PF-02545920 In Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 20 mg PF-02545920|DRUG: PF-02545920|DRUG: PF-02545920
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Estrogen Diastolic Heart Failure
Status: TERMINATED
Conditions: Menopause
Interventions: DRUG: Estradiol/Norethindrone acetate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of Triptorelin 3-Month Formulation in Chinese Children With Central Precocious Puberty.
Status: COMPLETED
Conditions: Central Precocious Puberty
Interventions: DRUG: Triptorelin pamoate 15mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Trial of Tipifarnib and Alpelisib in Adult Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)
Status: RECRUITING
Conditions: HNSCC
Interventions: DRUG: Tipifarnib|DRUG: Alpelisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Drug Combination on Pharmacokinetics in Healthy Volunteers
Status: COMPLETED
Conditions: Hepatitis C Infection
Interventions: DRUG: Escitalopram|DRUG: Sertraline|DRUG: DCV 3DAA FDC|DRUG: BMS-791325
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Pharmacokinetics of Intravaginal Rings Containing Vicriviroc (MK-4176) and/or MK-2048
Status: COMPLETED
Conditions: HIV Infections
Interventions: DEVICE: Vicriviroc (MK-4176) Intravaginal Ring (IVR)|DEVICE: MK-2048 IVR|DEVICE: MK-2048A IVR|DEVICE: Placebo IVR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Utility of Trimethoprim-sulfamethoxazole Use in Skin Abscess Management
Status: COMPLETED
Conditions: Skin Diseases, Infectious
Interventions: DRUG: Trimethoprim-sulfamethoxazole|DRUG: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between TOF and SWAN Sequences in the Detection of Arterial Occlusion in Acute Ischemic Stroke Using MRI
Status: COMPLETED
Conditions: Stroke, Acute|Angiography|Magnetic Resonance Imaging|Diagnosis
Interventions: DIAGNOSTIC_TEST: Magnetic resonance imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tolerability of Indacaterol Salts (Maleate, Xinafoate and Acetate) in Comparison to Placebo in Patients With Mild to Moderate Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Indacaterol maleate|DRUG: Indacaterol maleate|DRUG: Indacaterol maleate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: T-cell Childhood Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia
Interventions: DRUG: prednisone|DRUG: vincristine sulfate|DRUG: daunorubicin hydrochloride|DRUG: asparaginase|DRUG: methotrexate|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: mercaptopurine|DRUG: leucovorin calcium|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: thioguanine|RADIATION: radiation therapy|DRUG: nelarabine|DRUG: pegaspargase|RADIATION: radiation therapy|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect Of Intra-muscular Administration of Dexamethasone in Induction of Labour
Status: UNKNOWN
Conditions: Medical Induction of Labor Affecting Fetus
Interventions: DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficiency and Safety of Microwave Ablation Plus Immune Checkpoint Inhibitor for Patients With Multiple Primary Lung Cancer: A Open, Multi-center, Phase II Clinical Trial
Status: RECRUITING
Conditions: Multiple Primary Lung Cancer
Interventions: COMBINATION_PRODUCT: Microwave ablation plus Camrelizumab|DEVICE: Microwave ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Propionic Acid Supplementation on Endothelial Function
Status: NOT_YET_RECRUITING
Conditions: Cardiovascular Diseases|Endothelial Dysfunction
Interventions: DIETARY_SUPPLEMENT: Sodium Propionate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nebivolol Versus Metoprolol: Comparative Effects on Fatigue and Quality of Life
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Metoprolol|DRUG: Nebivolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study Comparing 2 Formulations for 4 mg Risperidone Tablet.
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorders
Interventions: DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Orelabrutinib Plus Lenalidomide and Rituximab (R2) Compared to Placebo Plus R2 in r/r Marginal Zone Lymphoma
Status: RECRUITING
Conditions: Relapsed/Refractory Marginal Zone Lymphoma
Interventions: DRUG: Orelabrutinib|DRUG: Lenalidomide|DRUG: Rituximab|DRUG: Orelabrutinib Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Obstructive Sleep Apnea Treatment in Patients With Metabolic Syndrome
Status: COMPLETED
Conditions: Sleep Apnea|Metabolic Syndrome
Interventions: DEVICE: CPAP (REMstar System One Plus - Philips Medical Systems)|DEVICE: Nasal strips
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zolpidem CR and Hospitalized Patients With Dementia
Status: COMPLETED
Conditions: Dementia|Alzheimer Disease|Dementia, Vascular|Sleep Disorders|Circadian Dysregulation
Interventions: DRUG: Zolpidem CR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Split-face, Randomized Study of the Poly-D, L Lactic Acid (PDLLA) for Photoaged Skin
Status: ACTIVE_NOT_RECRUITING
Conditions: Pigmentation|Pigmentation Disorder
Interventions: DRUG: PDLLA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Herbal Extract on Sleep Parameters
Status: ACTIVE_NOT_RECRUITING
Conditions: Sleep Onset Latency
Interventions: OTHER: Herbal extract drink|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of SARS-CoV-2 Variant mRNA Vaccine in Healthy Participants
Status: UNKNOWN
Conditions: SARS-CoV-2
Interventions: BIOLOGICAL: SARS-CoV-2 variant mRNA vaccine low dose|BIOLOGICAL: SARS-CoV-2 variant mRNA vaccine high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of RoActemra/Actemra (Tocilizumab) in Patients With Ankylosing Spondylitis Who Have Failed Treatment With NSAIDs
Status: TERMINATED
Conditions: Spondylitis, Ankylosing
Interventions: BIOLOGICAL: tocilizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DHA Supplementation in Patients With STGD3
Status: COMPLETED
Conditions: Dominantly Inherited Stargardt's Disease (STGD3)
Interventions: DIETARY_SUPPLEMENT: Over the counter DHA/EPA dietary supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cisplatin and Radiation Therapy Followed by Paclitaxel and Carboplatin in Treating Patients With Stage IB-IVA Cervical Cancer
Status: UNKNOWN
Conditions: Cervical Adenocarcinoma|Cervical Adenosquamous Carcinoma|Cervical Squamous Cell Carcinoma, Not Otherwise Specified|Stage IB Cervical Cancer AJCC v6 and v7|Stage IIA Cervical Cancer AJCC v7|Stage IIB Cervical Cancer AJCC v6 and v7|Stage IIIA Cervical Cancer AJCC v6 and v7|Stage IIIB Cervical Cancer AJCC v6 and v7|Stage IVA Cervical Cancer AJCC v6 and v7
Interventions: DRUG: Carboplatin|DRUG: Cisplatin|RADIATION: External Beam Radiation Therapy|RADIATION: Internal Radiation Therapy|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: D4T or Abacavir Plus Vitamin Enhancement in HIV-Infected Patients (DAVE)
Status: COMPLETED
Conditions: Acidosis, Lactic
Interventions: DRUG: d4T|DRUG: Abacavir|DRUG: Riboflavin and Thiamine (Supplementation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Nitrate and Muscle Power With Aging
Status: COMPLETED
Conditions: Aging|Sarcopenia
Interventions: DIETARY_SUPPLEMENT: placebo|DIETARY_SUPPLEMENT: nitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peripheral Stem Cell Transplantation Plus Combination Chemotherapy in Treating Patients With Low-Grade Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: DRUG: carmustine|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: dexamethasone|DRUG: etoposide|DRUG: melphalan|DRUG: paclitaxel|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Utilizing Qualitative and Quantitative Methods to Understand a New Model of Type 1 and 2 Systemic Lupus Erythematosus (SLE)
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: BEHAVIORAL: SLE@Duke
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Prevention of Contrast Induced Nephropathy by Erythropoietin
Status: UNKNOWN
Conditions: Diabetes|Chronic Kidney Insufficiency
Interventions: DRUG: Epoetin beta|DRUG: Saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Six vs 12 Months of Trastuzumab With Docetaxel Following FEC as Adjuvant Treatment in N+ Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Docetaxel|DRUG: Trastuzumab|DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: 5-fluoruracil|DRUG: Granulocyte-colony stimulating growth factor|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Open-Label Extension Trial for Subjects Completing the Phase 3 Trial of Fesoterodine (SP583) for the Treatment of Overactive Bladder Syndrome
Status: COMPLETED
Conditions: Overactive Bladder Syndrome
Interventions: DRUG: SPM 907
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: An Euglycemic Clamp Trial to Evaluate Pharmacokinetics of Single Doses of BioChaperone Insulin Lispro in Healthy Japanese Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Biochaperone insulin lispro 0.1 U/kg|DRUG: Biochaperone insulin lispro 0.2 U/kg|DRUG: Biochaperone insulin lispro 0.4 U/kg|DRUG: Humalog®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT