pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluating Panitumumab (ABX-EGF) in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Irinotecan|BIOLOGICAL: Panitumumab|DRUG: 5-Fluorouracil|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Trial of Metformin for Weight Control of Pediatric Patients on Antipsychotic Medications.
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder|Bipolar Disorder|Autism Spectrum Disorders
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TOPAZ: Tucatinib in COmbination With Pembrolizumab And TrastuZumab in Patients With HER2-Positive Breast Cancer Brain Metastases
Status: WITHDRAWN
Conditions: Breast Cancer|Brain Metastases|HER2-positive Breast Cancer|CNS Disease
Interventions: DRUG: Tucatinib|DRUG: Pembrolizumab|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nasal Allergen Challenge - Reproducibility of Biomarkers and Effect of Topical Steroid Treatment
Status: UNKNOWN
Conditions: Allergic Asthma
Interventions: DRUG: Triamcinolone Acetonide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reflux Disease in Head and Neck Cancer Patients Undergoing Radiation Therapy
Status: WITHDRAWN
Conditions: Head and Neck Cancer|Oropharyngeal Cancer|Gastroesophageal Reflux Disease
Interventions: DRUG: Dexlansoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Duvelisib and Food Effect on Pharmacokinetics of IPI-145
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: IPI-145 (duvelisib)|DRUG: IPI-145|DRUG: IPI-145
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Two Intermittent Urinary Catheters
Status: COMPLETED
Conditions: Urinary Retention
Interventions: DEVICE: 30 cm Intermittent Catheter|DEVICE: 40 cm Intermittent Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Nab-paclitaxel Combined With S-1 as Induction Therapy for Locally Advanced Pancreatic Cancer
Status: UNKNOWN
Conditions: Locally Advanced Pancreatic Cancer
Interventions: DRUG: Nab-paclitaxel and S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Navigating Resource-Constrained Systems and Communities to Promote the Behavioral Health of Black Youth
Status: RECRUITING
Conditions: Disruptive Behavior Disorder
Interventions: OTHER: Standard Care|OTHER: Child Behavioral Health Navigator (cbhN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Lutetium (177Lu) Vipivotide Tetraxetan in mCRPC Participants With Moderately and Severely Impaired and With Normal Renal Function
Status: RECRUITING
Conditions: Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Interventions: DRUG: AAA617|DRUG: 68Ga-PSMA-11
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Theta Burst Stimulation as an add-on Treatment for Bipolar Depression
Status: UNKNOWN
Conditions: Bipolar Disorder|Bipolar Depression|Bipolar I Disorder|Bipolar II Disorder|Depression|Mood Disorders|Mental Disorder
Interventions: DEVICE: cTBS|DEVICE: Sham cTBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Investigating STA363 Compared to Placebo in Patients With Chronic Discogenic Low Back Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Discogenic Pain
Interventions: DRUG: STA363 containing 90 mg (60 mg/mL) lactic acid|DRUG: STA363 containing 180 mg (120 mg/mL) lactic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test How Well Different Doses of BI 1356225 Are Tolerated by Men and Women With Obesity or Overweight
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: BI 1356225|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple Rising Does Study (Subcutaneous Doses) of BI 655064 in Male and Female Patients With Chronic Primary Immune Thrombocytopenic Purpura (ITP).
Status: TERMINATED
Conditions: Purpura, Thrombocytopenic, Idiopathic
Interventions: DRUG: BI 655064
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Incision Versus Standard Laparoscopic Splenectomy
Status: WITHDRAWN
Conditions: Hereditary Spherocytosis|Idiopathic Thrombocytopenic Purpura
Interventions: PROCEDURE: Single Incision Splenectomy|PROCEDURE: Laparoscopic Splenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Alpha-lipoic Acid on Biochemical Markers and Important Outcomes in Patients Admitted to Intensive Care Units
Status: UNKNOWN
Conditions: Oxidative Stress|Inflammation|Malnutrition
Interventions: DIETARY_SUPPLEMENT: alpha-lipoic acid|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 1/2, Open-Label, Dose Escalation, Safety and Tolerability Study of INCB050465 and Itacitinib in Subjects With Previously Treated B-Cell Malignancies (CITADEL-101)
Status: COMPLETED
Conditions: B-Cell Malignancies
Interventions: DRUG: Parsaclisib|DRUG: Itacitinib|DRUG: Rituximab|DRUG: Ifosfamide|DRUG: Carboplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Human Adipose Tissue-derived MSCs in Romberg's Disease
Status: COMPLETED
Conditions: Progressive Hemifacial Atrophy|Romberg's Disease
Interventions: PROCEDURE: Autologous Adipose Tissue derived MSCs Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Capecitabine, Oxaliplatin and Bevacizumab in Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Bevacizumab|DRUG: Oxaliplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD19/20 Bispecific Nanobody-derived CAR-T Cells in B Cell Lymphoma
Status: UNKNOWN
Conditions: B-Cell Lymphoma Stage I|Refractory|Relapsed
Interventions: BIOLOGICAL: CD19/CD20 bispecific CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Controlled and Multi-Center Study of 2500ml Huaren Peritoneal Dialysate
Status: UNKNOWN
Conditions: Disorders Associated With Peritoneal Dialysis
Interventions: OTHER: 2500ml Huaren peritoneal dialysate|OTHER: 2000ml peritoneal dialysate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Effects of Autologous Adipose-Derived Stem Cells in Patients With Frailty Syndrome
Status: WITHDRAWN
Conditions: Frailty Syndrome
Interventions: PROCEDURE: Harvesting and implantation of stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Vertical Versus Horizontal Vaginal Cuff Closure on Vaginal Length After Laparoscopic Hysterectomy
Status: COMPLETED
Conditions: Hysterectomy
Interventions: PROCEDURE: Vaginal cuff closure - vertical|PROCEDURE: Vaginal cuff closure - horizontal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Duloxetine for the Treatment of Generalized Anxiety Disorder
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: DRUG: Duloxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gong's Versus Kaltenborn Mobilization on Pain, Range of Motion and Function in Adhesive Capsulitis
Status: RECRUITING
Conditions: Adhesive Capsulitis|Frozen Shoulder
Interventions: OTHER: Gong's Mobilization|OTHER: Kaltenborn Mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of T-DXd in Participants With or Without Brain Metastasis Who Have Previously Treated Advanced or Metastatic HER2 Positive Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab Deruxtecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid-free Anesthesia in Gynecologic Surgery
Status: UNKNOWN
Conditions: Gynecologic Disease
Interventions: PROCEDURE: Opioid-free anesthesia|PROCEDURE: Opioid-using anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Ertugliflozin: Cardioprotective Effects on Epicardial Fat
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases|Atherosclerosis|Type 2 Diabetes|Insulin Resistance
Interventions: DRUG: Ertugliflozin|DRUG: Glipizide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Routine Outcome Monitoring and Feedback Informed Therapy in Italy
Status: NOT_YET_RECRUITING
Conditions: Feedback, Psychological
Interventions: BEHAVIORAL: (Feedback Informed Therapy) with Clinical Support Tools and ah hoc training|BEHAVIORAL: Feedback and ROM (basic)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Dose Finding Study Of PF-00489791 In Patients With Mild To Moderate High Blood Pressure
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: placebo|DRUG: PF-00489791|DRUG: PF-00489791|DRUG: PF-00489791
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Triumeq As an Integrase Single Tablet Regimen in People With HIV Who Inject Drugs
Status: TERMINATED
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: dolutegravir/abacavir/lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Intermittent Hypoxia Treatment in Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: OTHER: Hypoxia through modified hypoxic generator|OTHER: Normoxia through hypoxic generator without active elements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MOSAIC (MOthers' AdvocateS In the Community) for Pregnant Women and Mothers of Children Under 5 With Experience of Intimate Partner Violence
Status: NOT_YET_RECRUITING
Conditions: Intimate Partner Violence|Depression|Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: MOSAIC Plus|BEHAVIORAL: MOSAIC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Local and Imported Skin Prick Testing Result of Rat and Mouse Allergen Extracts
Status: COMPLETED
Conditions: Allergic Rhinitis Due to Animal Hair and Dander
Interventions: DIAGNOSTIC_TEST: rat and mouse skin test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of OV101 in Individuals With Fragile X Syndrome
Status: COMPLETED
Conditions: Fragile X Syndrome (FXS)
Interventions: DRUG: OV101 (gaboxadol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Six Week Pharmacokinetic Study of TP-03 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: TP-03 (Lotilaner Ophthalmic Solution), 0.25%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Kaiser Permanente Evaluating Nutritional Interventions in Food-Insecure High-Risk Adults Study
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Financial support for healthy foods and free home delivery|OTHER: Free home delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Sirolimus-Eluting Versus Paclitaxel-Eluting Stents for Coronary Revascularization
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DEVICE: Sirolimus-eluting stent|DEVICE: Paclitaxel-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Modified Process Hepatitis B Vaccine in Healthy Neonates (V232-056)
Status: COMPLETED
Conditions: Hepatitis B|Hepatocellular Carcinoma
Interventions: BIOLOGICAL: Comparator: RECOMBIVAX HB™|BIOLOGICAL: Comparator: Modified process Hepatitis B Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Dexmedetomidine to Reduce the Incidence of POCD After Open Cardiac Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Delirium|Postoperative Cognitive Dysfunction|Dexmedetomidine|Cognitive Impairment|Depression
Interventions: DRUG: Dexmedetomidine Hydrochloride Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bioavailability Study of Ramipril 10 mg Capsules of Dr. Reddy's Laboratories Limited Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ramipril|DRUG: Altace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RAD 1802: Pilot Trial of Five Fraction Stereotactic Body Radiotherapy for Early Stage Breast Cancer Patients Eligible for Post-Operative Accelerated Partial Breast Irradiation (APBI)
Status: SUSPENDED
Conditions: Breast Cancer
Interventions: RADIATION: 5 Fraction Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myeloid Cells in Patients With Covid-19 Pneumonia
Status: NOT_YET_RECRUITING
Conditions: Covid-19; SARS-Cov2
Interventions: OTHER: Blood sampling|OTHER: Nasal Brushing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Safety and Efficacy of H1N1 Vaccines in Children Aged 6 Months to Less Than 10 Years of Age
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: GSK Biologicals' investigational vaccine GSK2340274A (alternative formulations)|BIOLOGICAL: GSK Biologicals' investigational vaccine GSK2340273A (alternative formulations)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Guadecitabine and Atezolizumab in Treating Patients With Advanced Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia That Is Refractory or Relapsed
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Myelomonocytic Leukemia|Myelodysplastic Syndrome|Recurrent Acute Myeloid Leukemia With Myelodysplasia-Related Changes
Interventions: DRUG: Atezolizumab|DRUG: Guadecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predicting Acute Compartment Syndrome (PACS)
Status: COMPLETED
Conditions: Acute Compartment Syndrome
Interventions: OTHER: Continuous tissue perfusion monitoring by near-infrared spectroscopy (NIRS) and intramuscular pressure (IMP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Anlotinib in Patients With Esophageal Squamous Cell Carcinoma (ALTER1102)
Status: COMPLETED
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Anlotinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Codivir in Patients With COVID-19
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Covidir injections|DIAGNOSTIC_TEST: One Step Test|DIAGNOSTIC_TEST: IgM and IgG dosage|DIAGNOSTIC_TEST: RT-PCR SARS-CoV-2|DIAGNOSTIC_TEST: Screening blood test|DIAGNOSTIC_TEST: ECG|DIAGNOSTIC_TEST: Medical evaluation|DIAGNOSTIC_TEST: NEWS-2 score|DIAGNOSTIC_TEST: WHO score
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Functionally Non-significant Vulnerable Plaques in Patients With Multivessel ST-elevation Myocardial Infarction The VULNERABLE Trial
Status: RECRUITING
Conditions: Coronary Artery Disease|Coronary Disease|Ischemic Heart Disease
Interventions: OTHER: FFR>0.80+ OCT with findings indicative of vulnerable plaque|OTHER: FFR>0.80+ OCT with findings indicative of vulnerable plaque
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: BuqitongluO Granule for Qi Deficiency and Blood Stasis Syndrome
Status: UNKNOWN
Conditions: Stroke, Ischemic|Coronary Artery Disease|Angina Pectoris, Stable|Diabetic Peripheral Neuropathy
Interventions: DRUG: Buqitongluo Granule|DRUG: Buqitongluo Granule Placebo|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rituximab, Cyclophosphamide, and Pegfilgrastim in Treating Patients With Leukemia or Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: BIOLOGICAL: Pegfilgrastim|BIOLOGICAL: Rituximab|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BE Study in Patients - Methotrexate Tablets
Status: UNKNOWN
Conditions: Psoriasis|Rheumatoid Arthritis
Interventions: DRUG: Methotrexate - Amneal|DRUG: Methotrexate - DAVA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System
Status: RECRUITING
Conditions: Pulmonary Arterial Hypertension|Pulmonary Hypertension|Right Heart Dysfunction
Interventions: DEVICE: Aria CV Pulmonary Hypertension System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab Combination With Chemotherapy in Platinum-sensitive Recurrent Low-grade Serous Ovarian Cancer
Status: RECRUITING
Conditions: Ovarian Cancer|Low Grade Serous Carcinoma|Primary Peritoneal Carcinoma|Fallopian Tube Cancer
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicomponent Intervention in Caregivers on Quality of Life of People With Dementia: a Clinical Trial
Status: UNKNOWN
Conditions: Alzheimer Disease|Caregivers|Quality of Life
Interventions: OTHER: Multicomponent Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 68Ga-DOTA-NI-FAPI04 PET/CT in Patients With Various Types of Cancer
Status: RECRUITING
Conditions: Tumor
Interventions: DRUG: 68Ga-DOTA-NI-FAPI04|DRUG: 68Ga-FAPI/18F-FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Novosyn® CHD vs Polyglactin 910 Suture to Close Wounds After Emergency or Elective Laparotomy or Laparoscopic Surgery
Status: RECRUITING
Conditions: Surgical Site Infection
Interventions: DEVICE: Novosyn® in emergency or elective laparotomy or laparoscopic surgery|DEVICE: Polyglactin 910 in emergency or elective laparotomy or laparoscopic surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Protective Role of Oxcarbazepine in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Oxcarbazepine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Boosting the Impact of SMC Through Simultaneous Screening and Treatment of Roommates
Status: UNKNOWN
Conditions: Malaria
Interventions: DRUG: Amodiaquine Sulfadoxine-Pyrimethamin administration|DRUG: Dihydroartemisinin-Piperaquine|DIAGNOSTIC_TEST: Standard HRP2-RDT|DIAGNOSTIC_TEST: Highly sensitive RDT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Non-Inferiority Study of Erector Spinae Plane Block Compared to Thoracic Epidural in Pain Management of Rib Fractures
Status: WITHDRAWN
Conditions: Rib Fractures
Interventions: PROCEDURE: ESPB|PROCEDURE: TEA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lapatinib and Radiation for Stage III-IV Head and Neck Cancer Patients Who Cannot Tolerate Concurrent Chemotherapy
Status: TERMINATED
Conditions: Head and Neck Cancer|Carcinoma, Squamous Cell|Head and Neck Cancers
Interventions: DRUG: Lapatinib|PROCEDURE: Radiotherapy (radiation)|DEVICE: G.E. Healthcare 1.5T MR, systems revision 12.0 M5|DEVICE: DCE-MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Two Topical Anesthetics Prior to Fractional Nonablative Laser Treatment of the Face
Status: RECRUITING
Conditions: Anesthesia, Local|Photodamaged Skin|Topical and Infiltration Anesthetic Toxicity
Interventions: DRUG: 2.5 g of lidocaine 23% / tetracaine 7% ointment without occlusion|DRUG: 7.5 g lidocaine 2.5%/ prilocaine 2.5% cream with occlusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Frequent Cuff Inflations May Disrupt the Accuracy of 24-hour Ambulatory Blood Pressure Monitoring
Status: COMPLETED
Conditions: Hypertension
Interventions: DIAGNOSTIC_TEST: Ambulatory Blood Pressure Monitoring, frequent/non-frequent|DIAGNOSTIC_TEST: Ambulatory Blood Pressure Monitoring, non-frequent/frequent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Sirolimus Alone With Sirolimus Plus Tacrolimus in Type 1 Diabetic Recipients of Cultured Islet Cell Grafts
Status: TERMINATED
Conditions: Islet Transplantation|Type 1 Diabetes
Interventions: DRUG: ATG-Sirolimus-Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose:
Clinical trial: A Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy
Status: TERMINATED
Conditions: Neurotrophic Keratopathy
Interventions: DRUG: Cord Blood Eye Drops|DRUG: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Pharmacokinetics Study of Clopidogrel and Aspirin Fixed-dose Combination Versus Separate Combination-2nd Trial
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Clopidogrel and Aspirin|DRUG: Fixed dose combination of clopidogrel/aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Neoadjuvant TS-1 and Cisplatin for Type 4 and Large Type 3 Gastric Cancer
Status: COMPLETED
Conditions: Gastric Neoplasm
Interventions: PROCEDURE: Gastrectomy with more than D2 dissection|DRUG: Neoadjuvant chemotherapy(TS-1+CDDP) followed by gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Investigation of Biometry and Tomography Measurements in a Heterogeneous Patient Cohort
Status: UNKNOWN
Conditions: Cataract|Lens Opacities|Artificial Lens Implant|Corneal Astigmatism|Corneal Defect|Corneal Deformity
Interventions: DEVICE: Clinical Prototype BioBase (SN 07 and SN 08)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Effectiveness Study of Maca Root to Treat Antidepressant-Induced Sexual Dysfunction
Status: COMPLETED
Conditions: Depression|Sexual Dysfunction
Interventions: DRUG: Maca Root
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endovascular Denervation for the Treatment of Type 2 Diabetes Mellitus
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 2 Diabetes Mellitus (T2DM)
Interventions: DEVICE: Endovascular denervation System (Generator and Catheter )
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Designing an Implementation Strategy for Delivering Routine Mental Health Screening and Treatment
Status: TERMINATED
Conditions: Sickle Cell Disease|Depression|Anxiety
Interventions: BEHAVIORAL: off-the-shelf digital CBT|BEHAVIORAL: adapted digital CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Response to Oral Lansoprazole of Inorganic Pyrophosphate Levels in Patients With Grönblad-Stranberg Disease (Pseudoxanthoma Elasticum)
Status: UNKNOWN
Conditions: Grönblad-Stranberg Disease (Pseudoxanthoma Elasticum)
Interventions: DRUG: Lansoprazole 30mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Panmacular Versus Minimal Micropulse Laser Therapy in Central Serous Chorioretinopathy
Status: UNKNOWN
Conditions: Central Serous Chorioretinopathy
Interventions: PROCEDURE: Micropulse laser photostimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Autologous Platelet-Rich Plasma Intra-ovarian Infusion in Poor Responders
Status: RECRUITING
Conditions: Ovary; Anomaly|Infertility, Female
Interventions: BIOLOGICAL: PRP|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of LabPatch-alcohol as a Noninvasive Skin Patch to Detect Blood Alcohol Concentrations
Status: RECRUITING
Conditions: Alcohol Intoxication
Interventions: DIAGNOSTIC_TEST: LabPatch-alcohol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Comparing Efficacy of Bone Marrow Aspirate Concentrate (BMAC) Combined With Allograft in Treatment of Calcaneus Fractures
Status: WITHDRAWN
Conditions: Fractures, Bone
Interventions: DEVICE: Autograft|DEVICE: Allograft only|DEVICE: Allograft combined with BMAC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Actos Now for Prevention of Diabetes (ACT NOW)
Status: COMPLETED
Conditions: Impaired Glucose Tolerance|Type 2 Diabetes
Interventions: DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Burkitt Lymphoma/Leukemia and B Large Cell NHL
Status: COMPLETED
Conditions: Non-Hodgkin Lymphoma|Acute Lymphoblastic Leukemia, Mature B-Cell
Interventions: DRUG: Prednison, Vincristine, Cytarabine, Methotrexate, Etoposide, Cyclophosphamide, Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of 4% Boric Acid in Distilled Water Versus Clotrimazole Solution in Otomycosis Patients.
Status: UNKNOWN
Conditions: Otomycosis
Interventions: DRUG: Clotrimazol solution 1%|DRUG: 4%boric acid in distilled water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Longitudinal Measurements of Flow in Cerebrospinal Fluid Shunts With a Wireless Thermal Anisotropy Measurement Device
Status: RECRUITING
Conditions: Hydrocephalus
Interventions: DEVICE: Thermal Anisotropy Measurement Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Progesterone Versus Progesterone Plus Dydrogesterone in FET
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Micronized Progesterone|DRUG: Micronized progesterone plus dydrogesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Vascular and Cognitive Effects of Chronic High-flavanol Intake in Healthy Males
Status: UNKNOWN
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: High-flavanol milk choocolate|DIETARY_SUPPLEMENT: Low-flavanol milk chocolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of 5-day Dosing of ON 01910.Na in Intermediate-1,-2, or High Risk Myelodysplastic Syndrome (MDS)
Status: WITHDRAWN
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: ON 01910.Na Concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Ipatasertib or Apitolisib With Abiraterone Acetate Versus Abiraterone Acetate in Participants With Castration-Resistant Prostate Cancer Previously Treated With Docetaxel Chemotherapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Abiraterone|DRUG: Apitolisib|DRUG: Ipatasertib|DRUG: Placebo|DRUG: Prednisone|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Family-Based Treatment for Type 1 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1|Obesity, Childhood|Overweight|Comorbidities and Coexisting Conditions
Interventions: BEHAVIORAL: Family-Based Treatment for T1D
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Administration of ATG Followed by Cyclophosphamide, Busulfan and Fludarabine Before a Donor Stem Cell Transplant in Patients With Hematological Cancer
Status: COMPLETED
Conditions: Myeloproliferative Disorders|Kidney Cancer|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases
Interventions: BIOLOGICAL: anti-thymocyte globulin|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: fludarabine phosphate|DRUG: methotrexate|DRUG: tacrolimus|PROCEDURE: nonmyeloablative allogeneic HSCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplement in Preventing Colon Cancer in African Americans With Colon Polyps
Status: TERMINATED
Conditions: Colorectal Cancer|Precancerous Condition
Interventions: DIETARY_SUPPLEMENT: cholecalciferol|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Personalized Obstructive Sleep Apnea Treatment and Effects on Alzheimer's Disease Biomarkers and Cognition Among Blacks
Status: RECRUITING
Conditions: Sleep Apnea
Interventions: OTHER: Standard of Care|BEHAVIORAL: Personalized OSA Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Perioperative Electroacupuncture After Operation
Status: UNKNOWN
Conditions: Acupuncture|Gastrointestinal Function
Interventions: PROCEDURE: Electroacupuncture|PROCEDURE: Sham electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Prevention of Excessive Gestational Weight Gain Using Lifestyle Change
Status: COMPLETED
Conditions: Excessive Weight Gain in Pregnancy, First Trimester|Excessive Weight Gain in Pregnancy With Baby Delivered|Birth Weight
Interventions: BEHAVIORAL: NELIP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Compliance With PROMs Detection Through Digital Support and Correlation Compared Standard to Outpatient Detection in Knee Prosthetics
Status: RECRUITING
Conditions: Approach-Approach Conflict|Knee Discomfort
Interventions: BEHAVIORAL: Extrambulatory digital PROMs detection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Assessment of Ambulatory Polygraphy in the Detection of Sleep Apnea in Multiple System Atrophy (SAMSA)
Status: COMPLETED
Conditions: Sleep Apnea Syndromes|Multiple System Atrophy
Interventions: DEVICE: Polysomnography|DEVICE: ambulatory polygraphy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Bevacizumab and Paclitaxel for Neuroendocrine Tumors of the Cervix
Status: TERMINATED
Conditions: Cervical Cancer|Uterine Cancer
Interventions: DRUG: Bevacizumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intravenous Dexamethasone on Rebound Pain After Interscalene Brachial Plexus Block for Shoulder Surgery
Status: COMPLETED
Conditions: Rebound Pain
Interventions: PROCEDURE: Group C|PROCEDURE: Group Dex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, PK, PD of ADX-324 in Healthy Volunteers and Hereditary Angioedema Patients
Status: RECRUITING
Conditions: Hereditary Angioedema
Interventions: DRUG: ADX-324|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Community Participation for Stroke Survivors With Cognitive Impairments
Status: ACTIVE_NOT_RECRUITING
Conditions: Stroke|Cognitive Impairment
Interventions: BEHAVIORAL: Strategy Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Tolerability of E2511 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: E2511|DRUG: E2511 Matched Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The CRISIS Prevention Study
Status: TERMINATED
Conditions: Sepsis
Interventions: DRUG: Metoclopramide|DRUG: Zinc|DIETARY_SUPPLEMENT: Glutamine|DRUG: Selenium|OTHER: saline|OTHER: sterile water|OTHER: selenium|DIETARY_SUPPLEMENT: whey-protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Porfimer Sodium Interstitial Photodynamic Therapy With or Without Standard of Care Chemotherapy in Treating Patients With Locally Advanced or Recurrent Head and Neck Cancer
Status: RECRUITING
Conditions: Recurrent Head and Neck Carcinoma|Locally Advanced Head and Neck Carcinoma
Interventions: BIOLOGICAL: Nivolumab|DRUG: Porfimer Sodium|PROCEDURE: Interstitial Illumination Photodynamic Therapy|OTHER: Quality of Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACTIV-3b: Therapeutics for Severely Ill Inpatients With COVID-19
Status: COMPLETED
Conditions: Covid19
Interventions: BIOLOGICAL: Remdesivir|DRUG: Remdesivir Placebo|BIOLOGICAL: Aviptadil|DRUG: Aviptadil Placebo|DRUG: Corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of MK-6837 as a Monotherapy and Combination Therapy in Participants With Advanced/Metastatic Solid Tumors (MK-6837-001)
Status: RECRUITING
Conditions: Neoplasm Metastasis
Interventions: BIOLOGICAL: MK-6837|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Tolerability of Circumferential Anal Canal Radiofrequency Ablation For Anal Intraepithelial Neoplasia
Status: COMPLETED
Conditions: Anal Intraepithelial Neoplasia (AIN)|High-grade Squamous Intraepithelial Lesions (HSIL)
Interventions: DEVICE: Radiofrequency Ablation (Barrx™)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Olfactory Training as a Treatment for Olfactory Dysfunction Post COVID-19
Status: UNKNOWN
Conditions: Hyposmia|COVID-19|Parosmia|Anosmia|SARS-CoV-2 Infection
Interventions: OTHER: Smell training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction Assessment of GSK3882347 in Healthy Participants Aged 18 to 65 Years
Status: RECRUITING
Conditions: Urinary Tract Infections
Interventions: DRUG: Midazolam|DRUG: GSK3882347
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safe and Effective Use of a Zilucoplan Auto-injector by Study Participants With Generalized Myasthenia Gravis
Status: NOT_YET_RECRUITING
Conditions: Generalized Myasthenia Gravis
Interventions: DRUG: Zilucoplan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Corticosteroid Lumbar Epidural Analgesia for Radiculopathy
Status: COMPLETED
Conditions: Lumbosacral Radicular Pain
Interventions: DRUG: SP-102|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Examining the Effectiveness of a Critical Time Intervention to Stabilize Trajectories Out of Homelessness for Youth
Status: RECRUITING
Conditions: Homeless Persons
Interventions: BEHAVIORAL: Housing Outreach Project Collaboration (HOP-C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Designed Exercise Program on Pain and Quality of Sleeping in Patient With Sickle Cell Disease Anemia.
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: OTHER: Exercise training program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-SEMA4D Monoclonal Antibody VX15/2503 With Nivolumab or Ipilimumab in Treating Patients With Stage III or IV Melanoma
Status: TERMINATED
Conditions: Metastatic Melanoma|Stage III Cutaneous Melanoma AJCC v7|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7
Interventions: BIOLOGICAL: Anti-SEMA4D Monoclonal Antibody VX15/2503|BIOLOGICAL: Ipilimumab|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Nivolumab|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2a, Efficacy and Safety Study of Ustekinumab in Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Lupus Erythematosus, Systemic
Interventions: DRUG: Ustekinumab IV|DRUG: Placebo Infusion|DRUG: Placebo SC|DRUG: Ustekinumab SC|OTHER: Concomitant Medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Magnesium Sulphate and Lidocaine in Hemodynamic Changes and Cortisol Levels
Status: COMPLETED
Conditions: Intubation Complication
Interventions: DRUG: Magnesium Sulfate 20 MG/ML|DRUG: Lidocaine IV|DRUG: saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Stereotactic Body Radiation Therapy in Treating Patients With Liver Cancer That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Adult Hepatocellular Carcinoma|Advanced Adult Hepatocellular Carcinoma|Localized Non-Resectable Adult Liver Carcinoma|Recurrent Adult Liver Carcinoma
Interventions: RADIATION: Stereotactic Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial in Extensive-Disease Small Cell Lung Cancer (ED-SCLC) Subjects Comparing Ipilimumab Plus Etoposide and Platinum Therapy to Etoposide and Platinum Therapy Alone
Status: COMPLETED
Conditions: Small Cell Lung Carcinoma
Interventions: BIOLOGICAL: Ipilimumab|BIOLOGICAL: Placebo matching Ipilimumab|DRUG: Etoposide|DRUG: Cisplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Oral Cannabidiol (CBD)-Terpene Formulation on Sleep Physiology in Participants With Insomnia
Status: ACTIVE_NOT_RECRUITING
Conditions: Insomnia
Interventions: DRUG: Defined CBD|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Glucocorticoid Long-term Administration: Effect on Cold Induced Energy Expenditure and Resting Metabolic Rate
Status: COMPLETED
Conditions: Thermoregulation Impairment
Interventions: DIAGNOSTIC_TEST: Indirect calorimetry|DIAGNOSTIC_TEST: Skin Temperature|DIAGNOSTIC_TEST: Dual energy X-ray Absorptiometry (DXA)|DIAGNOSTIC_TEST: Blood Sampling|DIAGNOSTIC_TEST: FDG-PET|DIAGNOSTIC_TEST: Capillary glucose|DIAGNOSTIC_TEST: Biopsy of supraclavicular adipose tissue (optional)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chidamide+Decitabine Plus Anti-PD-1 Antibody for Patients With R/R cHL Who Are Transplant-ineligible or Refused Transplant.
Status: RECRUITING
Conditions: Ineligible Or Refused Transplant Patients With Classical Hodgkin Lymphoma
Interventions: DRUG: Chidamide; Decitabine; Anti-PD-1 Antibody|DRUG: Brentuximab Vedotin, anti-PD-1 antibody.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Group vs. Individual Cognitive Processing Therapy for Combat-related PTSD
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Group Cognitive Processing Therapy-Cognitive Only|BEHAVIORAL: Individual Cognitive Processing Therapy-Cognitive Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT