pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of Mud Bath Therapy in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: OTHER: Mud bath Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Effects of Brain Machine Interface in Chronic Stroke Patient
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: Experimental: RecoveriX with individual EEG calibration|DEVICE: RecoveriX without individual EEG calibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Characteristics of GLH1SM Extended Release Tablets in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: COMBINATION_PRODUCT: Janumet XR tablet 100/1000 mg|COMBINATION_PRODUCT: GLH1SM tablet 100/1000 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acoustic Cardiographic Assessment of Heart Function and the Role of Phrenic Nerve Stimulation
Status: COMPLETED
Conditions: Heart Failure, Congestive|Cardiac Pacing, Artificial|Transcutaneous Electric Nerve Stimulation
Interventions: PROCEDURE: Phrenic nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mangoselect®: Characterization, Pharmacokinetics and Bioavailability of Xanthone Metabolites
Status: COMPLETED
Conditions: Dietary Modification
Interventions: DIETARY_SUPPLEMENT: MNGDPF|DIETARY_SUPPLEMENT: MNGEF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: AZD6088 Single Ascending Dose Study
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: AZD6088|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluate the Efficacy and Safety of Lomitapide in Pediatric Patients With Homozygous Familial Hypercholesterolemia on Stable Lipid-lowering Therapy
Status: WITHDRAWN
Conditions: Homozygous Familial Hypercholesterolemia
Interventions: DRUG: Lomitapide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomised Trial Ketiapine Olanzapine Fast Sedation Agitated Patients Emergency Ward
Status: COMPLETED
Conditions: Psychomotor Agitation|Psychiatric Disorder|Emergency Psychiatric|Tranquilizers
Interventions: DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation Exercise With MObile Technology and Education After Acute Coronary Syndrome
Status: WITHDRAWN
Conditions: Acute Coronary Syndrome
Interventions: OTHER: Telerehabilitation (Tele RCV)|OTHER: Rehabilitation (RCV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Correlation of Serum Gasdermin-D and NLRP-3 Inflammasome Levels With GVHD Biomarkers and Endothelial Damage Markers in Graft-Versus-Host Disease
Status: RECRUITING
Conditions: Acute Myeloid Leukemia, Adult|Graft Versus Host Disease|Endothelial Dysfunction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation Of A Mobile Messaging Service In Improving Adherence Of Anti-Seizure Medications
Status: ENROLLING_BY_INVITATION
Conditions: Epilepsy|Treatment Adherence
Interventions: BEHAVIORAL: Mobile phone message reminders.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Temozolomide and Radiation Therapy With or Without Bevacizumab in Treating Patients With Newly Diagnosed Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma|Gliosarcoma|Supratentorial Glioblastoma
Interventions: RADIATION: 3-Dimensional Conformal Radiation Therapy|BIOLOGICAL: Bevacizumab|RADIATION: Intensity-Modulated Radiation Therapy|OTHER: Laboratory Biomarker Analysis|OTHER: Placebo|OTHER: Quality-of-Life Assessment|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Roflumilast Safety Administered Once a Day on Alternate Days for Two Weeks Compared to the Usual Dosage Once Daily
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Roflumilast alternated days|DRUG: Roflumilast 500 mcg per day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Usefulness of the Tsui Test in Combined Spinal-Epidural Analgesia in Labour
Status: COMPLETED
Conditions: Labor Pain
Interventions: PROCEDURE: Combined spinal epidural|PROCEDURE: Tsui Test for intrathecal catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of a Combined Program of Pelvic Floor Muscle Training and Yoga
Status: NOT_YET_RECRUITING
Conditions: Genitourinary Symptoms|Sexual Function|Quality of Life
Interventions: BEHAVIORAL: Pelvic Floor Muscle Training (PFMT) and yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploration of Dalpiciclib + Chidamide in HR+/HER2- Advanced Breast Cancer After Failure of CDK4/6 Inhibitor: a Phase Ⅰb Study
Status: NOT_YET_RECRUITING
Conditions: HR+/HER2- Advanced Breast Cancer
Interventions: DRUG: Dalpiciclib|DRUG: Chidamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation to Validate the Safety and Performance of the ABLE Exoskeleton Device for Individuals With Multiple Sclerosis in a Clinical Setting
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DEVICE: ABLE Exoskeleton
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin B6 Aids in Treating Inflammatory Bowel Disease
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases
Interventions: DRUG: Vitamin B6 Tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunologic Effects of Supplemental Monosaccharide and Nucleoside Derivatives in Patients With Inherited Disorders of Glycosylation
Status: TERMINATED
Conditions: PGM3
Interventions: DRUG: N-Acetylglucosamine (GlcNAc)|DRUG: Uridine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Local Analgesia on Postoperative Gluteal Pain in Patients Undergoing Sacrospinous Ligament Fixation
Status: TERMINATED
Conditions: Postoperative Pain|Pelvic Organ Prolapse|Trigger Point Injection|Sacrospinous Ligament Fixation
Interventions: DRUG: marcaine and kenalog
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neo-adjuvant Chemotherapy Evluation in Gastric Cancer Patients Based on Circulating Exosomal LncRNA-GC1
Status: RECRUITING
Conditions: Gastric Cancer|Chemotherapy Effect
Interventions: DIAGNOSTIC_TEST: Detection of levels of circulating EV-derived lncRNA-GC1
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Bevacizumab/Temsirolimus Combination to Treat Advanced Renal Cell Carcinoma
Status: TERMINATED
Conditions: Kidney Cancer
Interventions: DRUG: Bevacizumab|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Insulin Aspart in Children With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin aspart|DRUG: human insulin|DRUG: isophane human insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Distress and Improving Self-Care in Diabetes
Status: COMPLETED
Conditions: Diabetes Type 2
Interventions: BEHAVIORAL: Lifestyle and Activities Education Program (LEAP-AHEAD)|BEHAVIORAL: Computer Automated Self-Management (CASM)|BEHAVIORAL: Computer Automated Self-Management and Problem Solving Therapy (CAPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Milk Powder With Fiber and Probiotics on Digestive Habits and General Health Well-being of Selected Filipino Mothers.
Status: COMPLETED
Conditions: Constipation
Interventions: DIETARY_SUPPLEMENT: ANMUM In-Shape Nutritional Milk Powder for Active Mothers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Low Amplitude Vibration Therapy on Flexibility of Hamstring Muscle in Athletes of Pakistan
Status: COMPLETED
Conditions: Hamstring Contractures|Whole Body Vibration
Interventions: OTHER: Conventional static hamstring muscle stretching|DEVICE: Low amplitude whole body vibration therapy|DEVICE: Biodex Balance System|PROCEDURE: Range of motion of hamstring muscle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: E4 FREEDOM (Female Response Concerning Efficacy and Safety of Estetrol/Drospirenone as Oral Contraceptive in a Multicentric Study) - United States/Canada Study
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: 15 mg E4/3 mg DRSP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Olfaction in Patients With Parkinson's Disease Following Treatment With Rasagiline
Status: COMPLETED
Conditions: Parkinson´s Disease
Interventions: DRUG: Azilect 1mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pilot Efficacy of AKB-9778 in Subjects With Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema (DME)
Interventions: DRUG: Subcutaneous AKB-9778
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Roxadustat in the Treatment of Anemia in End Stage Renal Disease (ESRD) Patients on Stable Dialysis
Status: COMPLETED
Conditions: Anemia|End Stage Renal Disease (ESRD)
Interventions: DRUG: Roxadustat|DRUG: Epoetin alfa|DRUG: Darbepoetin alfa|DRUG: Iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Organ-sparing With TraceIT® for Rectal Cancer Radiotherapy
Status: TERMINATED
Conditions: Rectal Tumors|Rectal Cancer|Advanced Cancer
Interventions: DEVICE: TraceIT®|RADIATION: Volumetric Arc Therapy (VMAT)|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Oral NX-13 in Active Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: NX-13 250mg IR|DRUG: NX-13 500mg IR|DRUG: NX-13 500mg MR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multiple Dose Study Of PF-04950615 (RN316) In Subjects On Maximum Doses Of Statins
Status: COMPLETED
Conditions: Hypercholesterolemia|Dyslipidemia
Interventions: OTHER: Placebo|DRUG: PF-04950615 (RN316)|DRUG: PF-04950615 (RN316)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Integrating Cancer Control Referrals and Navigators Into United Way 211 Missouri
Status: COMPLETED
Conditions: Cancer
Interventions: BEHAVIORAL: Phone Referral|BEHAVIORAL: Tailored Cancer Communication|BEHAVIORAL: Cancer Control Navigator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Three Summary of Finding Tables to Improve Understanding in the Presentation of Systematic Review Results
Status: COMPLETED
Conditions: Research Report
Interventions: OTHER: Current GRADE SoF table|OTHER: Alternative GRADE SoF table|OTHER: EPC SoF table
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Clinical Trial to Evaluate the Safety and Immunogenicity of BG505 MD39.3, BG505 MD39.3 gp151, and BG505 MD39.3 gp151 CD4KO HIV Trimer mRNA Vaccines in Healthy, HIV-uninfected Adult Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections
Interventions: BIOLOGICAL: BG505 MD39.3 mRNA|BIOLOGICAL: BG505 MD39.3 gp151 mRNA|BIOLOGICAL: BG505 MD39.3 gp151 CD4KO mRNA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Telehealth Intervention Strategies for WIC (THIS-WIC)- Michigan
Status: COMPLETED
Conditions: Telehealth|Nutrition Education|Breast Feeding|Dietary Intake|WIC
Interventions: BEHAVIORAL: Telehealth solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Time to Thrombocytic Inhibition After Supine and Upright Ingestion of Efient
Status: COMPLETED
Conditions: Heart Disease|Ischemic Heart Disease|ST-elevation Myocardial Infarction
Interventions: OTHER: Upright position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conditioning Regimen and the Transplantation of Unrelated Donor Umbilical Cord Blood in Patients With Hematologic Malignancies.
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndrome|Non-Hodgkins Lymphoma|Chronic Myelogenous Leukemia|Hodgkins Lymphoma
Interventions: DRUG: fludarabine, cyclophosphamide, thiotepa, radiation therapy, unrelated donor umbilical cord blood graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Nursing Care Based on Kolcaba's Comfort Theory on the Newborn
Status: RECRUITING
Conditions: Pain|Comfort Theory|Hemodynamic Variables
Interventions: OTHER: Care based on Kolcaba's comfort theory
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Applying Pharmacogenetics to Warfarin Dosing in Chinese Patients
Status: UNKNOWN
Conditions: Atrial Fibrillation|Deep Vein Thrombosis|Pulmonary Embolism|Heart Valve Disease
Interventions: OTHER: Genotype-guided warfarin dosing|OTHER: Non-genotype guided warfarin dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Pharmacodynamics of Meropenem in Patient With Ventilator-associated Pneumonia
Status: COMPLETED
Conditions: Ventilator-Associated Pneumonia
Interventions: DRUG: Meropenem|DRUG: Meropenem|DRUG: Meropenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Improving Maternal Sleep and Mental Health
Status: NOT_YET_RECRUITING
Conditions: Postpartum Depression|Postpartum Anxiety|Sleep Disturbance|Infant Behavior|Maternal Behavior|Inflammation|Military Family
Interventions: DEVICE: Smart Bassinet|DEVICE: HALO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacity of Cognitive Remediation Treatment Compared to a Controlled Group in Young Patient With Anorexia Nervosa
Status: COMPLETED
Conditions: Anorexia Nervosa
Interventions: BEHAVIORAL: Cognitive remediation therapy|OTHER: relaxation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Weekly Intravenous Administrations of BI 836845 in Japanese Patients With Advanced Solid Tumours
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Xentuzumab, low dose, every week (qw)|DRUG: Xentuzumab, middle dose, qw|DRUG: Xentuzumab, high dose, qw
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Looking Glass: Bimanual Balanced Reaching With Visual Biofeedback
Status: RECRUITING
Conditions: Stroke|Stroke, Acute|Healthy
Interventions: OTHER: Veridical Visual Feedback|OTHER: Augmented Visual Feedback|OTHER: Healthy Comparative Reaching Task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of Sabin Inactivated Poliovirus Vaccine in Infants
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: sIPV vaccine /DTaP vaccine|BIOLOGICAL: sIPV vaccine /Hepatitis A inactivated vaccine /MMR vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection (PUNCH CD3-OLS)
Status: COMPLETED
Conditions: Clostridium Difficile Infection|Infection|Communicable Diseases
Interventions: DRUG: RBX2660
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis
Status: RECRUITING
Conditions: Metastatic Breast Cancer|Leptomeningeal Disease
Interventions: DRUG: High-dose Methotrexate (8 gm/m2; HD-MTX)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurocognitive Function After Prophylactic Cranial Irradiation & Hippocampal Sparing in LD SCLC Patients - a Pilot Study
Status: UNKNOWN
Conditions: Carcinoma, Small Cell
Interventions: RADIATION: Whole brain radiotherapy with reduced dose to the hippocampi
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 2017 A/H7N9 IIV Revaccination
Status: COMPLETED
Conditions: Avian Influenza|Influenza Immunisation
Interventions: BIOLOGICAL: A/H7N9|DRUG: AS03|OTHER: Phosphate Buffered Saline (PBS) diluent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Influence of Weight Loss or Exercise on Cartilage in Obese Knee Osteoarthritis Patients
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Obesity
Interventions: BEHAVIORAL: Dietary instruction|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cystatin-C C-guided Vancomycin Dosing in Critically Ill Patients: A Quality Improvement Project
Status: COMPLETED
Conditions: Methicillin-resistant Staphylococcus Aureus|Sepsis|Critical Illness
Interventions: DRUG: Vancomycin|OTHER: Cystatin C dosing algorithm|OTHER: Creatine clearance dosing algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice
Status: COMPLETED
Conditions: Helicobacter Pylori
Interventions: DRUG: PPI, amoxicillin, metronidazole and clarithromycin|DRUG: PPI, amoxicillin, metronidazole and clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Efficacy of Deferasirox in Transfusion Dependent Chronic Anaemias (Myelodysplastic Syndrome, Beta-thalassaemia Patients) With Chronic Iron Overload
Status: COMPLETED
Conditions: Myelodysplastic Syndromes|Beta-Thalassemia
Interventions: DRUG: deferasirox
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Giomer Based Varnish Versus CPP-ACP Varnish in the Management of Dentin Hypersensitivity: a Randomized Clinical Trial
Status: RECRUITING
Conditions: Dentin Hypersensitivity
Interventions: PROCEDURE: Giomer Varnish|PROCEDURE: CPP-ACP varnish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-eluting Balloon in Bifurcations Trial
Status: COMPLETED
Conditions: Coronary Artery Disease|Atherosclerosis|Stable Angina|Unstable Angina
Interventions: DEVICE: Drug eluting balloon|DEVICE: Liberté|DEVICE: PTCA balloon catheter|DEVICE: Taxus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Udenafil on Spermatogenesis
Status: COMPLETED
Conditions: Spermatogenesis|Erectile Dysfunction
Interventions: DRUG: Placebo|DRUG: Udenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Preoperative Melatonin or Vitamin C Administration on Postoperative Analgesia
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Melatonin|DRUG: Vitamin C|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Assess the Rate and Extent of Absorption of Hydrocodone From 20 mg Hydrocodone Bitartrate Extended-Release Capsules
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HC-ER 20 mg capsule (fasted)|DRUG: HC-ER 20 mg capsule (fed)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: NICEFIT-ON: A Study Under Routine Clinical Practice in Taiwan to Observe the Long-term Outcome of People With Certain Types of Lung Disease (PF-ILD, SSc-ILD, IPF) Who Start Treatment With Nintedanib
Status: ACTIVE_NOT_RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: OFEV®
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dinaciclib and Epirubicin Hydrochloride in Treating Patients With Metastatic Triple-Negative Breast Cancer
Status: COMPLETED
Conditions: Estrogen Receptor Negative|HER2/Neu Negative|Male Breast Carcinoma|Progesterone Receptor Negative|Recurrent Breast Carcinoma|Stage IV Breast Cancer AJCC v6 and v7|Triple-Negative Breast Carcinoma
Interventions: DRUG: Dinaciclib|DRUG: Epirubicin Hydrochloride|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of the MBHP on the Quality of Life of Family Members of People With Intellectual Disability
Status: UNKNOWN
Conditions: Quality of Life
Interventions: BEHAVIORAL: Mindfulness meditation|BEHAVIORAL: Psychotherapy group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pain Multidisciplinar Intervention in Major Trauma Patients
Status: RECRUITING
Conditions: Trauma|Chronic Pain|Psychological Trauma
Interventions: DRUG: Paracetamol|DRUG: Ibuprofen 600 mg|DRUG: Tramadol|DRUG: Morphine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nutrition Sufficiency, Allergy Efficacy and Safety of Neocate Jr in Children With Food Protein Allergy
Status: UNKNOWN
Conditions: Food Allergy in Children|Cow Milk Allergy
Interventions: DIETARY_SUPPLEMENT: Amino acid formula (Neocate Jr)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Exercise and Diet on Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: OTHER: Diet|OTHER: Exercise|OTHER: Diet and Exercise|OTHER: Healthy Lifestyle (Control) Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Efficacy and Safety of SER-287 in Adults With Active Mild-to-Moderate Ulcerative Colitis
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: DRUG: Vancomycin Pre-Treatment|DRUG: Placebo for Vancomycin Pre-Treatment|DRUG: SER-287|DRUG: Placebo for SER-287
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Chronic and Acute Effects of Nordic Berry Beverage on Cognitive Function
Status: COMPLETED
Conditions: Age-related Cognitive Decline
Interventions: OTHER: Active berry product|OTHER: Reference berry-like product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Safety Study of IV Stem Cell-derived Extracellular Vesicles (UNEX-42) in Preterm Neonates at High Risk for BPD
Status: TERMINATED
Conditions: Bronchopulmonary Dysplasia
Interventions: BIOLOGICAL: UNEX-42|BIOLOGICAL: Phosphate-buffered saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ED-Home Pilot Study
Status: COMPLETED
Conditions: Housing Problems|Drug Use|Alcohol; Use, Problem
Interventions: BEHAVIORAL: Referral to homelessness prevention services|BEHAVIORAL: Substance use services|BEHAVIORAL: Follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Efficacy, Pharmacokinetics, Safety and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression
Status: COMPLETED
Conditions: Depressive Disorder, Treatment-Resistant
Interventions: DRUG: Esketamine 56 mg|DRUG: Esketamine 84 mg|DRUG: Placebo|DRUG: Duloxetine (Oral Antidepressant)|DRUG: Escitalopram (Oral Antidepressant)|DRUG: Sertraline (Oral Antidepressant)|DRUG: Venlafaxine Extended Release (XR) (Oral Antidepressant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of the Venous Window Needle Guide to Access Arteriovenous (AV)Fistulae
Status: COMPLETED
Conditions: End Stage Renal Disease|AV Fistula|Kidney Failure
Interventions: DEVICE: Venous Window Needle Guide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paroxetine for Comorbid Social Anxiety Disorder and Alcoholism
Status: COMPLETED
Conditions: Social Anxiety Disorder|Social Phobia|Alcohol Use Disorder|Alcohol Abuse|Alcohol Dependence
Interventions: DRUG: Paroxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Stereotactic Body Radiation Therapy or Non-Stereotactic Wide-Field Radiation Therapy in Treating Patients With Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Solid Neoplasm|Metastatic Lung Non-Small Cell Carcinoma|Stage IV Lung Non-Small Cell Cancer AJCC v7
Interventions: RADIATION: 3-Dimensional Conformal Radiation Therapy|RADIATION: Intensity-Modulated Radiation Therapy|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab|RADIATION: Proton Beam Radiation Therapy|RADIATION: Radiation Therapy|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoxygenation Optimisation in Obese Patients
Status: COMPLETED
Conditions: Severe Obesity Design as BMI > 35kg/m2
Interventions: DEVICE: High flow oxygen therapy by nasal cannula. Optiflow®|DEVICE: Facial mask oxygenation in BIPAP ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Use of Lung Ultrasound for Suspected Pneumonia in Nepal
Status: COMPLETED
Conditions: Pneumonia
Interventions: DEVICE: Lung Ultrasound|DEVICE: Chest X-ray|DEVICE: Chest Computed Tomography (CT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Awake Prone Positioning to Reduce Invasive VEntilation in COVID-19 Induced Acute Respiratory failurE
Status: TERMINATED
Conditions: ARDS, Human|Mechanical Ventilation Complication|COVID19
Interventions: PROCEDURE: Prone Positioning|PROCEDURE: Standard of care.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Switching From TDF to TAF vs. Maintaining TDF in Chronic Hepatitis B With Resistance to Adefovir or Entecavir.
Status: COMPLETED
Conditions: Chronic Hepatitis b
Interventions: DRUG: Tenofovir Alafenamide|DRUG: Tenofovir Disoproxil Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metacognitive Intervention for Individuals With Severe Mental Disorders
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Metacognitive Group Intervention|BEHAVIORAL: Occupational therapy standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gain in Stretched Penile Length After Phalloplasty With & Without Penile Traction in Children.
Status: RECRUITING
Conditions: Concealed Penis
Interventions: PROCEDURE: Traction Dressing|OTHER: Without Traction Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Alisertib, Bortezomib, and Rituximab in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma or B-cell Low Grade Non-Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent B-Cell Non-Hodgkin Lymphoma|Recurrent Mantle Cell Lymphoma|Refractory B-Cell Non-Hodgkin Lymphoma|Refractory Mantle Cell Lymphoma
Interventions: DRUG: Alisertib|DRUG: Bortezomib|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Which is Better to Start With DPP-4 Inhibitors or SGLT-2 Inhibitors in Egyptian Diabetic Patients?
Status: COMPLETED
Conditions: Diabete Type 2
Interventions: DRUG: Sitagliptin 50 mg|DRUG: Empagliflozin 12.5 MG|DRUG: Sitagliptin 50 mg + Empagliflozin 12.5 MG|DRUG: Empagliflozin 12.5 MG + Sitagliptin 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Olanzapine for Nausea/Vomiting Prophylaxis in Recipients of Hematopoietic Stem Cell Transplants
Status: COMPLETED
Conditions: Chemotherapy-induced Nausea and Vomiting
Interventions: DRUG: Olanzapine 5 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: RDEA3170 and Allopurinol Combination Study in Gout Subjects
Status: COMPLETED
Conditions: Gout
Interventions: DRUG: RDEA3170 10 mg|DRUG: allopurinol 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Prospective, Multicenter, Randomized Controlled Clinical Study on the Efficacy and Safety of Xuanfei Baidu Granule in the Treatment of Influenza A
Status: RECRUITING
Conditions: Influenza A
Interventions: DRUG: Xuanfei Baidu Granule Placebo|DRUG: Xuanfei Baidu Granule|DRUG: Baloxavir Marboxil Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Potato-based Food Pattern vs a Rice / Pasta-based Food Pattern on Cardiometabolic Health
Status: UNKNOWN
Conditions: Glucose Metabolism|Lipid Metabolism
Interventions: OTHER: Potato|OTHER: Pasta/rice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study in Healthy Volunteers to Compare Different Tablet Formulations of the Test Medicine, GLPG1972, Against the Current Tablet Formulation, and to Assess the Effect Food Has on One of the Test Medicines
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG1972 - A|DRUG: GLPG1972 - B|DRUG: GLPG1972 - C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 2 Study of Association Gemcitabine-Cisplatin to Treat Penis Epidermoid Carcinoma
Status: COMPLETED
Conditions: Genital Neoplasms, Male
Interventions: DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HoLEP (50W) vs. HoLEP (100W) for Treatment of BPH
Status: COMPLETED
Conditions: Prostatic Hyperplasia
Interventions: PROCEDURE: Low power Holmium laser enucleation of the prostate|PROCEDURE: High power Holmium laser enucleation of the prostate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Singing and Cardiovascular Health in Older Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases|Cardiovascular Risk Factor|Cardiovascular Health
Interventions: OTHER: Singing with Music Therapist|OTHER: Singing with Guided Video|OTHER: Control Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sequential Regimen of Bendamustin-Debulking Followed by Ofatumumab and Ibrutinib in CLL Patients (CLL2-BIO)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Bendamustine|DRUG: Ofatumumab|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Motivational Interviewing in Patients With Bipolar Disorder
Status: UNKNOWN
Conditions: Motivational Interviews|Bipolar Disorder
Interventions: BEHAVIORAL: Assigned Interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I Trial of Memory T Cells Expressing an NKG2D Chimeric Antigen Receptor in Children, Adolescents and Young Adults With Advanced Sarcoma
Status: RECRUITING
Conditions: Advanced Sarcoma
Interventions: OTHER: NKG2D-CAR memory T cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of Sacituzumab Govitecan Plus Berzosertib in Small Cell Lung Cancer, Extra-Pulmonary Small Cell Neuroendocrine Cancer and Homologous Recombination-Deficient Cancers Resistant to PARP Inhibitors
Status: RECRUITING
Conditions: HRD Cancer|SCLC|Advanced Solid Tumors
Interventions: DRUG: Berzosertib|DRUG: Sacituzumab Govitecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Enriched Environment on the Risk of Relapse
Status: RECRUITING
Conditions: Alcoholic Relapse
Interventions: BEHAVIORAL: Multisensory virtual reality pod (SENSIKS©)|BEHAVIORAL: Cognitive bike (Vélo-cognitif®)|OTHER: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy and Tolerance of Oral Treatment With a Total Freeze-dried Culture of Lcr Restituo® Sachets (Lactobacillus Rhamnosus Lcr35®) on Intolerance to Metformin (Diarrhoea) in Patients With Diabetes Type 2
Status: UNKNOWN
Conditions: Antidiarrhoea
Interventions: DRUG: Lcr restituo® sachet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Probiotics (VSL) on Portal Hypertension
Status: COMPLETED
Conditions: Portal Hypertension
Interventions: DRUG: Probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Active Cycle Breathing Technique Along With Incentive Spirometer on COVID19 Patient
Status: COMPLETED
Conditions: Corona Virus Infection
Interventions: OTHER: active cycle breathing|OTHER: incentive spirometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Demonstrate the Efficacy and Safety of Conversion to Lacosamide Monotherapy for Partial-onset Seizures
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Lacosamide|DRUG: Lacosamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Propranolol and Misoprostol Versus Misoprostol Alone for Induction of Labor in Primigravidas
Status: COMPLETED
Conditions: Induction of Labor Affected Fetus / Newborn
Interventions: DRUG: Misoprostol|DRUG: Placebo|DRUG: Propranolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study in Leucocytes From Patients With Type 1 and Type 2 Diabetes Genetic Markers of Inflammation and Oxidative Stress (TÉLOMÈRES/ CANDIDATE GENES) According to the Type A or Type B Behavior Profile
Status: TERMINATED
Conditions: Patients With Type 1 or Type 2 Diabetes|Patients With a Type A or B Behaviour Profile
Interventions: OTHER: Blood sample of 12 ml
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of the Effect of Rifampicin on the Pharmacokinetics (PK) of Multiple Doses of Cediranib in Patients With Solid Tumours
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumors
Interventions: DRUG: cediranib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Lanreotide Autogel/ Depot 120 mg vs. Placebo in Subjects With Lung Neuroendocrine Tumours
Status: TERMINATED
Conditions: Neuroendocrine Tumors in Lung
Interventions: DRUG: Lanreotide (Autogel formulation)|DRUG: Placebo|DRUG: Best Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Acceptability of a Text Messaging Intervention to Increase Smoking Cessation in Vietnam
Status: COMPLETED
Conditions: Smoking
Interventions: BEHAVIORAL: Interventional Automated mobile phone text|BEHAVIORAL: Control Automated mobile phone text
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Tumour Spectrum of Germline Mutations in Breast and Ovarian Cancer Genes.
Status: ACTIVE_NOT_RECRUITING
Conditions: Hereditary Breast and Ovarian Cancer|Mutation
Interventions: OTHER: Genetic testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Suggested Rehabilitation Protocol for the Treatment of C-shape Scoliosis
Status: RECRUITING
Conditions: Idiopathic Scoliosis|Scoliosis Idiopathic|Rehabilitation|C-shape
Interventions: OTHER: traction and mobilization|OTHER: active exercise therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Dexketoprofen Trometamol/Tramadol Hydrochloride Analgesic Efficacy in Acute Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: Dexketoprofen Trometamol 25 mg/Tramadol Hydrochloride 75 MG|DRUG: Tramadol Hydrochloride 100 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Using the "CGM GUARDIAN 2" Interstitial Fluid Glucose Measurement System in Intensive Care Medicine
Status: RECRUITING
Conditions: Hyperglycemia|Hypotension|Shock, Septic
Interventions: DEVICE: CGM GUARDIAN 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Preservation of Inferior Mesenteric Artery Could Improve Sexual Function After Laparoscopic Colorectal Resection for Diverticular Disease
Status: COMPLETED
Conditions: Sexual Function Disturbances
Interventions: PROCEDURE: Inferior Mesenteric Artery Preservation|PROCEDURE: Inferior Mesenteric Artery Ligation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: β-D-Glucan (BDG) Surveillance With Preemptive Anidulafungin vs. Standard Care for Invasive Candidiasis in Surgical Intensive Care Unit (SICU) Patients
Status: COMPLETED
Conditions: Invasive Candidiasis
Interventions: DRUG: Preemptive Therapy with Anidulafungin|DRUG: Empiric antifungal therapy based on physician discretion.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Effects of Oral Oxybutynin and Oxybutynin Chloride Topical Gel in Older Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: oxybutynin chloride immediate-release|DRUG: oxybutynin chloride topical gel|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Beyond TME Origins
Status: RECRUITING
Conditions: Neoplasms|Adenocarcinoma|Carcinoma
Interventions: PROCEDURE: New Radiological Staging Classification system for patients with advanced and recurrent colorectal cancer undergoing pelvic exenterative surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supporting Sustained HIV Treatment Adherence After Initiation
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections|Adherence, Medication
Interventions: BEHAVIORAL: M1/OTR: Immediate outreach to subject due to unsuppressed viral load test result|BEHAVIORAL: M2/PRM: Immediate outreach to subject after a missed pharmacy refill|BEHAVIORAL: M3/EAM: Immediate outreach to subject after EAM-identified missed doses|BEHAVIORAL: S1/Text: Weekly check-in texts|BEHAVIORAL: S2/Peer: Enhanced peer group support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KEYS to Succeed: Cognitive and Academic Intervention Program for Children and Adolescents Surviving Cancer
Status: COMPLETED
Conditions: Childhood Brain Tumor
Interventions: BEHAVIORAL: Jump Math|BEHAVIORAL: Cogmed|BEHAVIORAL: Liaison Services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study Comparing Modified Release To Immediate Release Apixaban Tablets In Healthy Volunteers
Status: COMPLETED
Conditions: Thrombosis
Interventions: DRUG: Apixaban IR|DRUG: Apixaban MR1|DRUG: Apixaban MR2|DRUG: Apixaban MR3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Percutaneous Plug-based Arteriotomy Closure Device Use in Minimally Invasive Mitral Valve Surgery
Status: COMPLETED
Conditions: Mitral Valve Disease
Interventions: PROCEDURE: Percutaneous arteriotomy closed using a plug-based arteriotomy closure device|PROCEDURE: Surgical cut-down and arterial puncture under direct vision
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p