pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Binocular Computer Activities for Treatment of Amblyopia
Status: COMPLETED
Conditions: Amblyopia
Interventions: DEVICE: iPad®|OTHER: Patching 2 hours per day, 7 days per week
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Billroth II With Roux-en-Y Reconstruction for Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer|Stomach Cancer|Gastrectomy
Interventions: PROCEDURE: Roux-en-Y or Billroth II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NRP104, Adderall XR or Placebo in Children Aged 6-12 Years With ADHD
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: NRP104|DRUG: Adderall XR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First in Human Study of NG-350A (an Oncolytic Adenoviral Vector Which Expresses an Anti-CD40 Antibody)
Status: COMPLETED
Conditions: Metastatic Cancer|Epithelial Tumor
Interventions: BIOLOGICAL: NG-350A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telemedicine in Total Hip Arthroplasty and Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Osteoarthritis|Hip Osteoarthritis
Interventions: PROCEDURE: Telemedicine|PROCEDURE: In-Person Clinic Visit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digital Versus Conventional Impression Technique in Mandibular Arch
Status: ACTIVE_NOT_RECRUITING
Conditions: Edentulous Jaw
Interventions: DEVICE: intraoral scanner of nonsplinted scan bodies|DEVICE: impression material|DEVICE: intraoral scanner of splinted scan bodies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Burden of Obstructive Sleep Apnea in Stroke (BOSAST)
Status: TERMINATED
Conditions: Stroke|Obstructive Sleep Apnea
Interventions: DEVICE: CPAP|DEVICE: CPAP at sub-therapeutic pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of AEB071 Versus Cyclosporine in de Novo Renal Transplant Recipients
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: cyclosporine (reduced exposure) / everolimus|DRUG: AEB071 300 mg b.i.d. / everolimus|DRUG: AEB071 200 mg b.i.d. / everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ENHANCE-Efficacy of the Presence of Right Ventricular Apical Pacing Induced Ventricular Dyssynchrony as a Guiding Parameter for Biventricular Pacing in Patients With Bradycardia and Normal Ejection Fraction
Status: COMPLETED
Conditions: Bradycardia
Interventions: DEVICE: CRT-P OFF|DEVICE: CRT-P ON|DEVICE: DDDR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Transference-Focused Psychotherapy for Borderline Personality Disorder
Status: COMPLETED
Conditions: Borderline Personality Disorder
Interventions: BEHAVIORAL: Transference-Focused Psychotherapy|BEHAVIORAL: treatment by experienced community psychotherapists
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine for Immediate Perioperative Analgesia in Pediatric Patients Undergoing Tonsillectomy
Status: COMPLETED
Conditions: Tonsillitis
Interventions: DRUG: Fentanyl|DRUG: Fentanyl|DRUG: Dexmedetomidine|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Apatinib (Also Known as Rivoceranib) Plus Nivolumab in Participants With Unresectable or Metastatic Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Apatinib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Immune Response Study of 2 Experimental HIV Vaccines
Status: COMPLETED
Conditions: HIV Infection
Interventions: BIOLOGICAL: ALVAC-HIV|BIOLOGICAL: Bivalent Subtype C gp120/MF59®|BIOLOGICAL: ALVAC-HIV (vCP2438) Placebo|BIOLOGICAL: Bivalent gp120/MF59® Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Keyo in Children With Epilepsy
Status: COMPLETED
Conditions: Intractable Epilepsy|Glucose Transporter Type 1 Deficiency Syndrome|Ketogenic Dieting
Interventions: DIETARY_SUPPLEMENT: Keyo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient Satisfaction and Bone Gain Following Autogenous Particulate Sticky Bone Preparation With Xenograft Versus Without Xenograft for Grafting of Maxillary Anterior Knife Edge Ridge in Partially Edentulous Patients for Implant Placement
Status: UNKNOWN
Conditions: Alveolar Bone Loss|Bone Graft; Complications
Interventions: PROCEDURE: Sticky bone augmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Anterior Resection With or Without "Dog Ear" Double-stapled Anastomosis for Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Carcinoma|Laparoscopy|Anastomotic Leak
Interventions: PROCEDURE: without "Dog Ear" group|PROCEDURE: with "Dog Ear" group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-dose Maximal-intent Versus Controlled-tempo Resistance Training on Quality-of-life in Older Adults
Status: RECRUITING
Conditions: Quality of Life
Interventions: OTHER: Leg Press Resistance Training (3x5)|OTHER: Leg Press Resistance Training (5x5)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Persistence of Protective Antibody Titers 12-24 Months After NmVac4-A/C/Y/W-135-DT Vaccination: Follow Up Study
Status: COMPLETED
Conditions: Meningococcal Meningitis|Meningococcal Infections
Interventions: BIOLOGICAL: NmVac4-A/C/Y/W-135-DT™
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preparation Rich in Growth Factors (PRGF) Treatment for Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: BIOLOGICAL: PRGF|DRUG: hyaluronic acid|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Advanced Periodontitis With a Chitosan Brush and a Chitosan Gel
Status: RECRUITING
Conditions: Periodontitis|Periodontal Pocket|Periodontal Diseases|Periodontal Inflammation
Interventions: DEVICE: 4% chitosan gel (pH 3.48).|DEVICE: Reciprocal Chitosan brush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of SHR6508 in Secondary Hyperparathyroidism
Status: ACTIVE_NOT_RECRUITING
Conditions: Secondary Hyperparathyroidism
Interventions: DRUG: SHR6508|DRUG: SHR6508|DRUG: Cinacalcet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strategy for Adequate Blood Pressure Lowering in the Patients With Intracranial Atherosclerosis
Status: TERMINATED
Conditions: Brain Ischemia
Interventions: PROCEDURE: Aggressive BP lowering|PROCEDURE: modest blood pressure lowering
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Balloon Sinuplasty Efficiency in Maxillary Rhinosinusitis.
Status: RECRUITING
Conditions: Maxillary Sinusitis|Sinusitis, Chronic|Sinusitis Recurrent|Eustachian Tube Dysfunction
Interventions: PROCEDURE: Balloon sinuplasty of maxillary sinuses|PROCEDURE: Sham surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ALX-0171 Phase I Study, Evaluating Single Ascending Dose and Multiple Dose in Healthy Male Volunteers
Status: COMPLETED
Conditions: RSV Infection
Interventions: BIOLOGICAL: ALX-0171|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Spinal Decompression Plus Nerve Graft Implantation Following TSCI
Status: RECRUITING
Conditions: Spinal Cord Injuries|Acute Traumatic Spinal Cord Injury
Interventions: PROCEDURE: DMED|PROCEDURE: ANGI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Microfocused Ultrasound Technique in the Treatment of Facial Skin Laxity
Status: ACTIVE_NOT_RECRUITING
Conditions: Middle and Lower Face and Submental Region Skin Laxity
Interventions: PROCEDURE: HIFU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes and Inadequate Glycemic Control With Insulin Glargine, With or Without Metformin and/or SGLT-2 Inhibitor
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: Orforglipron|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tolvaptan for Hyponatremia in Cirrhotic Patients With Ascites
Status: UNKNOWN
Conditions: Hyponatremia|Ascites
Interventions: DRUG: Tolvaptan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vision Testing in Patients With Partial Seizures Receiving Either Lyrica or Placebo
Status: COMPLETED
Conditions: Epilepsies, Partial
Interventions: DRUG: Lyrica (pregabalin)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Artemisinin Combination Regimens in Falciparum Malaria
Status: UNKNOWN
Conditions: Uncomplicated Falciparum Malaria
Interventions: DRUG: AM(FDC)|DRUG: AM(LT)|DRUG: AL|DRUG: DP|DRUG: AA(FDC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Clinical Study Evaluating the Safety and Efficacy of Anti-CEA-CAR-T Cells Injection in Patients With CEA+ Locally Advanced and/or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Carcinoma
Interventions: BIOLOGICAL: Intravenous infusion anti-CEA-CAR-T cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Restoration of Upper Limb Function in Individuals With Sub-Acute Spinal Cord Injury
Status: TERMINATED
Conditions: Spinal Cord Injury
Interventions: DEVICE: Functional Electrical Stimulation (Compex Motion Stimulator)|OTHER: Conventional Occupational therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Pediatric Participants With Generalized Anxiety Disorder
Status: COMPLETED
Conditions: Anxiety Neuroses|Anxiety States, Neurotic|Neuroses, Anxiety
Interventions: DRUG: Duloxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Head Cooling in Preterm Infants With Hypoxic Ischemic Encephalopathy
Status: COMPLETED
Conditions: Hypoxic Ischemic Encephalopathy
Interventions: DEVICE: Olympic Cool Cap
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accuracy of LASIK Flaps Created With the LenSx® Femtosecond Laser - A Pilot Study
Status: COMPLETED
Conditions: Myopia|Hyperopia
Interventions: DEVICE: Femtosecond Laser System|PROCEDURE: LASIK surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cannabis for Palliative Care in Cancer
Status: RECRUITING
Conditions: Sleep|Anxiety|Depression|Pain
Interventions: DRUG: fsCBD Cannabidiol|DRUG: Placebo|DRUG: bsCBD Cannabidiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Non-surgical Periodontal Therapy on the Gingival Crevicular Fluid Levels of Prolactin Hormone in Patients With Periodontitis.
Status: COMPLETED
Conditions: Periodontitis|Prolactin in GCF
Interventions: PROCEDURE: non-surgical periodontal therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to See if hENT1 Testing on Tumour Tissue Can Predict Response to Treatment With Gemcitabine Chemotherapy and if a Different Chemotherapy Called FOLFOX is Better Than Gemcitabine in Metastatic Pancreas Cancer
Status: UNKNOWN
Conditions: Metastatic Pancreas Cancer
Interventions: DRUG: 5FU, leucovorin, oxaliplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRI Markers of Feedback Timing During Learning in Individuals With TBI With and Without Clinical Depression
Status: RECRUITING
Conditions: Traumatic Brain Injury|Major Depressive Disorder
Interventions: BEHAVIORAL: Learning through feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Does Caffeine Reduce Postoperative Bowel Paralysis After Elective Colectomy?
Status: TERMINATED
Conditions: Postoperative Ileus|Laparoscopic Colectomy Without Stoma Formation|Colorectal Neoplasm|Diverticulitis
Interventions: DRUG: Caffeine (100 mg)|DRUG: Caffeine (200 mg)|DRUG: corn starch (250 mg approx.)|OTHER: Radiopaque marker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the KPCXM18 Injection for Treatment of Acute Ischemic Stroke
Status: NOT_YET_RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DRUG: The KPCXM18 injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Omarigliptin (MK-3102) in Obese Participants and in Participants With Type 2 Diabetes (MK-3102-004)
Status: COMPLETED
Conditions: Type 2 Diabetes (T2D)
Interventions: DRUG: Omarigliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Microfluidic Chip Method Versus Density-gradient Centrifugation Method in IVF
Status: NOT_YET_RECRUITING
Conditions: Infertility
Interventions: DEVICE: Microfluidic chip|DEVICE: Density-gradient centrifugation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison FloShield Air System Versus Clearify Visualization System (D-HELP)
Status: COMPLETED
Conditions: Laparoscopic Surgery
Interventions: PROCEDURE: Laparoscopic surgery|DEVICE: FloShield Defogging and Cleaning System|DEVICE: Clearify Defogging and Cleaning System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Evaluation of Visual Functions After Pars Plana Vitrectomy With and Without Internal Limiting Membrane Peeling in RRD
Status: COMPLETED
Conditions: Retinal Detachment
Interventions: OTHER: Pars Plana Vitrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Immunoglobulin Associated With Rituximab Versus Rituximab Alone in Childhood-Onset Steroid-dependent Nephrotic Syndrome
Status: SUSPENDED
Conditions: Steroid-Dependent Nephrotic Syndrome
Interventions: DRUG: immunoglobulin IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Neuroprotective Effect of Remote Ischemic Conditioning in Ruptured Aneurysm Coiling Therapy
Status: UNKNOWN
Conditions: Aneurysm, Ruptured|Coiling Therapy
Interventions: DEVICE: remote ischemic conditioning|DEVICE: sham remote ischemic conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Rotational Atherectomy System Associated With Drug Coated Balloon Angioplasty in Limb Ischemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Peripheral Vascular Diseases
Interventions: DEVICE: Percutaneous transluminal angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Essential Oils in Stoma Bags on Deodorization, Life Satisfaction, Stoma Adaptation in Individuals With Colostomy
Status: COMPLETED
Conditions: Stoma Site Odor
Interventions: OTHER: LAVENDER OIL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Vildagliptin vs. Glibenclamide in Endothelial Function in Type 2 Diabetes and Hypertension
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Hypertension|Endothelial Dysfunction
Interventions: DRUG: Glibenclamide|DRUG: Vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Abatacept in Patients With Diffuse Systemic Sclerosis (Scleroderma)
Status: COMPLETED
Conditions: Scleroderma, Diffuse|Scleroderma, Systemic
Interventions: DRUG: Abatacept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Compression Feedback for Patients With In-hospital Cardiac Arrest
Status: COMPLETED
Conditions: Cardiopulmonary Arrest|Cardiopulmonary Resuscitation
Interventions: DEVICE: Audiovisual compression feedback|OTHER: Standard Manual Chest Compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ethnic Differences in Response to Topical Capsaicin: A Psychophysical Study on Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Capsaicin|DRUG: Placebo moisturizing cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: DETECT III - A Multicenter, Phase III Study to Compare Standard Therapy +/- Lapatinib in HER2-ve MBC-Patients With HER2+ve CTCs
Status: COMPLETED
Conditions: HER2-negative Metastatic Breast Cancer|HER2-positive Circulating Tumor Cells
Interventions: DRUG: standard chemo- or endocrine therapy|DRUG: standard chemo- or endocrine therapy + Lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FOLFOX + Panitumumab According to a "Stop and go" Strategy With a Reintroduction Loop After Progression on Fluoropyrimidine as Maintenance Treatment, as the First Line in Patients With Metastatic Colorectal Adenocarcinoma Without a RAS Mutation
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: COMBINATION_PRODUCT: FOLFOX + panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of Two Formulations Lamotrigine 100 mg Tablets and Lamictal 100 mg Tablets in Healthy Adult Volunteers Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DRUG: Lamotrigine|DRUG: Lamictal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pom-dex Versus Pom-Cyclo-dex in MM Patients With Biochemical or Clinical Relapse, During Lena Maintenance Treatment
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Pomalidomide|DRUG: Cyclophosphamide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transformative Learning to Virtual Inter-Professional Education in Musculoskeletal Pain
Status: NOT_YET_RECRUITING
Conditions: Musculoskeletal Pain
Interventions: OTHER: Transformative Learning principles|OTHER: Conventional didactic approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Florbetaben (BAY94-9172) PET (Positron Emission Tomography) Imaging in MCI (Mild Cognitive Impairment) Patients
Status: COMPLETED
Conditions: Alzheimer Disease|Amyloid Beta-Protein
Interventions: DRUG: Florbetaben (BAY94-9172)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Fundus Image-guided Focal Electroretinography, Usability Study
Status: COMPLETED
Conditions: Healthy|Macular Edema|Macular Degeneration
Interventions: DEVICE: ERG electrode tests for fundus image-guided focal ERG|DEVICE: Fundus image-guided focal ERG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Acute Comfort and Blur Profile of a Lubricant Eye Drop Versus a Marketed Lubricant Eye Gel
Status: COMPLETED
Conditions: Dry Eye
Interventions: OTHER: Lubricant eye drop FID 115958D|OTHER: GenTeal Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Velocity 2: An Anthrax Vaccine and Antibiotics Clinical Study
Status: COMPLETED
Conditions: Anthrax
Interventions: DRUG: Ciprofloxacin 500Mg Tablet|DRUG: Doxycycline 100Mg Tablet|BIOLOGICAL: AV7909
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cyclophosphamide and Docetaxel or Doxorubicin in Treating Women With Newly Diagnosed Breast Cancer That Can Be Removed by Surgery
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: docetaxel|DRUG: doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of MLN8237 and Pazopanib in Patients With Solid Tumors
Status: COMPLETED
Conditions: Malignant Neoplasm of Breast|CNS Malignancy|Malignant Neoplasm of Gastrointestinal Tract|Genitourinary Neoplasms Malignancy and Gender Unspecified|Head and Neck Neoplasms|Melanoma|Malignant Neoplasm of Thorax
Interventions: DRUG: Alisertib|DRUG: Pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Rehabilitation Using Functional Electrical Stimulation Assisted Supine Cycling in the Intensive Care Unit
Status: UNKNOWN
Conditions: ICU Acquired Weakness
Interventions: DEVICE: Functional electrical stimulation assisted supine cycling (FESC)|OTHER: Conventional early exercise and mobility interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: RP2/RP3 in Combination With Atezolizumab and Bevacizumab for the Treatment of Patients With CRC
Status: ACTIVE_NOT_RECRUITING
Conditions: Refractory Metastatic Colorectal Cancer|pMMR|MSS
Interventions: BIOLOGICAL: RP2|BIOLOGICAL: RP3|BIOLOGICAL: atezolizumab|BIOLOGICAL: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ortho-R® for Rotator Cuff Repair Compared With Standard of Care Rotator Cuff Repair Without Ortho-R®
Status: UNKNOWN
Conditions: Rotator Cuff Tears
Interventions: DRUG: Ortho-R/PRP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Patterns After Administration of MCFAs in Psoriasis and Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriasis|Psoriatic Arthritis
Interventions: DIETARY_SUPPLEMENT: PEVCO|DIETARY_SUPPLEMENT: Dietary Supplement Capsules without Coconut Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Non-surgical Periodontal Treatment and C-reactive Protein Levels in Hemodialysis Patients
Status: UNKNOWN
Conditions: Chronic Kidney Disease Stage 5|Periodontitis
Interventions: PROCEDURE: immediate treatment|PROCEDURE: postponed treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Randomized Trial of Fruits or Nuts Eaten Between Regular Meals in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DIETARY_SUPPLEMENT: Fruits|DIETARY_SUPPLEMENT: Nuts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Diet Selection Based on Genetic Screening on Success to a Weight Loss Program
Status: COMPLETED
Conditions: Diet Modification
Interventions: OTHER: Positive CIQ plus High Carbohydrate Diet|OTHER: Positive CIQ plus High Protein Diet|OTHER: Negative CIQ plus High Carbohydrate Diet|OTHER: Negative CIQ plus High Protein Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluating Renal Masses Using Ultrasound Intravenous Microbubble Contrast
Status: COMPLETED
Conditions: Renal Cancer|Kidney Cancer
Interventions: DRUG: Ultrasound with intravenous microbubble contrast injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prevention of Arrhythmia Device Infection Trial (PADIT Pilot)
Status: COMPLETED
Conditions: Arrythmias
Interventions: DRUG: Cefazolin, Bacitracin, Cefalexin|DRUG: Cefazolin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Use of iFOBT in Patients Presenting With Alarm Symptoms of Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Neoplasms|Colorectal Cancer|Colorectal Carcinoma|Colorectal Adenoma|Colorectal Adenocarcinoma
Interventions: DIAGNOSTIC_TEST: Immunochemical faecal occult blood test (iFOBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Saline Versus Albumin Fluid for Extracorporeal Removal With Slow Low Efficiency Dialysis Feasibility Study
Status: COMPLETED
Conditions: Renal Replacement Therapy|Acute Kidney Injury|Hypotension
Interventions: BIOLOGICAL: 25% Albumin fluid|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Effect of "Eucerin AtopiControl" on Dermal Symptoms in Patients With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis|Allergy Pollen
Interventions: DRUG: 'Eucerin AtopiControl Lotion' (for the body)|OTHER: Allergen challenge chamber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Effect of Insulin and Sodium Hyaluronate Injection Guided by Ultrasound in Carpal Tunnel Syndrome
Status: UNKNOWN
Conditions: Carpal Tunnel Syndrome
Interventions: DRUG: Insulin|DRUG: Sodium Hyaluronate|DEVICE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant PD-1 Antibody Alone or Combined With DC Vaccines for Recurrent Glioblastoma
Status: UNKNOWN
Conditions: Recurrent Glioblastoma
Interventions: BIOLOGICAL: Camrelizumab plus GSC-DCV|BIOLOGICAL: Camrelizumab plus Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multiple Dose Study to Assess the Safety and Tolerability of BMS-986166 in Healthy Volunteers
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: BMS-986166|OTHER: Placebo matching BMS-986166
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: A Clinical Study for the Effect of 4th Generation Poly AmidoAmine Dendrimer on Post-Bleaching Hypersensitivity and Shade Stability
Status: COMPLETED
Conditions: Tooth Hypersensitivity
Interventions: OTHER: Poly amido amine dendrimer (PAMAM)|OTHER: Manufacturer's desensitizing agent, Ultra EZ|OTHER: MI paste plus, desensitizing agent|OTHER: Hydroxyapatite and F (ReminPro), desensitizing agent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Shockwave™Peripheral Intravascular Lithotripsy Balloon for Advanced Endovascular Aortic Repair
Status: NOT_YET_RECRUITING
Conditions: Thoracoabdominal Aortic Aneurysm, Without Mention of Rupture|Abdominal Aortic Aneurysm Without Rupture|Thoracic Aortic Aneurysm Without Rupture
Interventions: DEVICE: Shockwave™ Peripheral Intravascular Lithotripsy Balloon M5+
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Propylene Glycol/Glycerol Intake and Cardiorespiratory Function
Status: COMPLETED
Conditions: Lung Injury
Interventions: OTHER: Nicotine free intake|OTHER: Nicotine intake|OTHER: Cessation intake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Two Biphasic Insulin Aspart 30 Formulations (Current and New Formulation) in Healthy Volunteers
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: biphasic insulin aspart 30
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Malignant Glial Tumors of the Brain
Status: UNKNOWN
Conditions: Glioma
Interventions: DRUG: 5-Aminolevuline Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Epidural Anesthesia and Analgesia on Patients' Outcomes After Liver Resection
Status: COMPLETED
Conditions: Hepatectomy
Interventions: PROCEDURE: epidural anesthesia and analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Autologous PRF, 1% Alendronate and 1.2% Atorvastatin Gel in Chronic Periodontitis Treatment
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: PROCEDURE: Open flap debridement (OFD)|BIOLOGICAL: OFD with PRF|DRUG: OFD with ALN|DRUG: OFD with ATV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-oxLDL IgM Antibodies as a Novel Therapy for Metabolic Lipid Diseases
Status: UNKNOWN
Conditions: Lipid Metabolism, Inborn Errors
Interventions: BIOLOGICAL: Anti-oxLDL IgM antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atrial Fibrillation (AF) Ablation to Prevent Disease Progression of AF-induced Atrial Cardiomyopathy in Women and Men
Status: NOT_YET_RECRUITING
Conditions: Fibrillation, Atrial|Atrial Cardiomyopathy
Interventions: PROCEDURE: Pulmonary vein isolation|DRUG: Pharmacological rhythm management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Subepithelial Connective Tissue Graft Versus Socket Shield Technique In Immediately Placed Implants
Status: COMPLETED
Conditions: Immediate Implants
Interventions: PROCEDURE: Classic Immediate implant|PROCEDURE: Immediate implant combined with subepithelial connective tissue graft|PROCEDURE: Immediate dental implant placement using socket shield technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of DCC-2701 in Participants With Advanced Solid Tumors
Status: TERMINATED
Conditions: Locally Advanced Tumors|Metastatic Solid Tumors|Cancers With MET Genomic Alterations|Cancers With TRK Genomic Alterations
Interventions: DRUG: DCC-2701 tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diabeloop WP6.2 : Crossover Evaluation of Glycemic Control
Status: COMPLETED
Conditions: Closed Loop|Diabetes Mellitus, Type 1
Interventions: DEVICE: Diabeloop System|DEVICE: Continuous Glucose Monitoring|DEVICE: Accelerometer and heart rate monitor|DIETARY_SUPPLEMENT: Meals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Perclose Escalation Technique for Vascular Closure in TAVR
Status: NOT_YET_RECRUITING
Conditions: Aortic Valve Stenosis|Structural Valve Deterioration|Structural Valve Degeneration
Interventions: DEVICE: One Perclose Proglide Suture|DEVICE: Two Perclose Proglide Suture
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adrenocorticotropic Hormone Stimulation in Postural Orthostatic Tachycardia Syndrome (POTS)
Status: COMPLETED
Conditions: Postural Tachycardia Syndrome
Interventions: DRUG: Cosyntropin administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Trial to Study the Influence of Growth Factors on Bone Marrow and Hepatic Regeneration in Patients With Decompensated Cirrhosis.
Status: COMPLETED
Conditions: Decompensated Cirrhosis
Interventions: DRUG: G-CSF+Erythropoetin|DRUG: G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The TREND Study: Tapered Reduction in Energy Intake as a Novel Approach to Dieting
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Tapered Low Calorie Diet|BEHAVIORAL: Traditional Low-Calorie Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab in the Treatment of Graves' Disease
Status: COMPLETED
Conditions: Graves´ Disease|Thyroid Associated Ophthalmopathy
Interventions: DRUG: Methimazole|DRUG: Rituximab|BIOLOGICAL: Immunization with various vaccines
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bintrafusp Alfa and Doxorubicin Hydrochloride in Treating Patients With Advanced Sarcoma
Status: RECRUITING
Conditions: Advanced Soft-tissue Sarcoma|Metastatic Soft-tissue Sarcoma
Interventions: DRUG: Bintrafusp alfa|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total Neoadjuvant Therapy of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer (ENSEMBLE)
Status: RECRUITING
Conditions: Locally Advanced Rectal Cancer
Interventions: RADIATION: SCRT|DRUG: CAPOX|DRUG: CAPOXIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study to See How Much CagriSema (1.0 mg Once Weekly) Lowers Blood Sugar and Body Weight Compared to Tirzepatide (5 mg Once Weekly) in People With Type 2 Diabetes Treated With Metformin, SGLT2 Inhibitor or Both
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Cagrilintide|DRUG: Semaglutide|DRUG: Tirzepatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trials of the Consistency and Non-inferiority Bridging Between Batches of Recombinant New Coronavirus Vaccine (CHO Cells)
Status: UNKNOWN
Conditions: Coronavirus Disease 2019
Interventions: BIOLOGICAL: Recombinant new coronavirus vaccine (CHO cell) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Repeated Low-Level Red-Light Therapy on Visual Field Damage in Primary Open-angle Glaucoma
Status: UNKNOWN
Conditions: Open Angle Glaucoma|Eye Diseases
Interventions: DEVICE: RLRL therapy|DRUG: Routine IOP-lowering medications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer|Oral Complications|Radiation Toxicity
Interventions: DRUG: cevimeline hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I Study of the Chimeric Anti-CD40 Monoclonal Antibody ChiLob 7/4 to Treat Advanced Malignancies Refractory to Conventional Anti-cancer Treatment
Status: COMPLETED
Conditions: Cancer|Neoplasms|Lymphoma|Non-Hodgkin|B-Cell
Interventions: DRUG: Chi Lob 7/4 (A chimeric monoclonal antibody)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose:
Clinical trial: Gemcitabine, Paclitaxel, and Cisplatin in Treating Patients With Advanced Cancer of the Urothelium
Status: COMPLETED
Conditions: Bladder Cancer|Transitional Cell Cancer of the Renal Pelvis and Ureter
Interventions: DRUG: cisplatin|DRUG: gemcitabine hydrochloride|DRUG: paclitaxel|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Glycemic and Insulinemic Responses Elicited by Meals Containing Whole Grain Rye Bread or White Wheat Bread
Status: UNKNOWN
Conditions: Blood Glucose Concentration
Interventions: OTHER: Wheat bread|OTHER: margarine|OTHER: ham|OTHER: soup|OTHER: rye bread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Effectiveness of Computerized Device New of Visual Motor Simulation Versus Mirror Therapy in Hemiplegic Patients.
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Intensive Visual Simulation 3 (IVS3) device|DEVICE: traditional Mirror Therapy (TM)|DEVICE: Electroencephalography (EEG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preoperative RESpiratory Training and MOBilization to Prevent Postoperative Pulmonary Complications in Patients Undergoing Thoracic Surgery
Status: RECRUITING
Conditions: Postoperative Complications|Procedure, Thoracic Surgical
Interventions: BEHAVIORAL: Inspiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Palonosetron Plus Dexamethasone in Moderately Emetogenic Chemotherapy Induced Nausea and Vomiting (Study P04594)
Status: COMPLETED
Conditions: Neoplasms|Nausea|Vomiting
Interventions: DRUG: Palonosetron and Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of RCT on Periapical Healing, Inflammatory Markers, and Kidney Function Indicators in CKD Patients With AP
Status: RECRUITING
Conditions: Apical Periodontitis|Chronic Kidney Diseases
Interventions: PROCEDURE: root canal treatment in Ckd patients|PROCEDURE: root canal treatment in healthy patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-label Clinical Trial to Investigate the Safety and Tolerability of Allogeneic B-cell Concentrates for Immune Reconstitution After Allogeneic Stem Cell Transplantation Measured as Response to a Antedated Single Vaccination
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Chronic Myeloid Leukemia|Non Hodgkin's Lymphoma|Hodgkin's Disease|Myelodysplastic Syndrome|Multiple Myeloma|Aplastic Anemia
Interventions: BIOLOGICAL: allogeneic donor derived B-lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Pegylated Interferon Lambda Plus Single or 2 Direct Antiviral Agents With Ribavirin
Status: COMPLETED
Conditions: Hepatitis C
Interventions: BIOLOGICAL: Pegylated Interferon Lambda|DRUG: Ribasphere|DRUG: Daclatasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FitMi AD Home Therapy for Individuals With MCI or Mild Dementia Due to Alzheimer's Disease
Status: RECRUITING
Conditions: Cognitive Dysfunction|Dementia, Mild
Interventions: DEVICE: FitMi AD|OTHER: Conventional exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Postmarket Clinical Trial for EXCROSSAL Stent in CAD Patients With 3-month DAPT or 12-month DAPT
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: EXCROSSAL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Dose of ASP3772 Study in Japanese Healthy Male and Female Adults, and Single Ascending Dose Study of ASP3772 in Comparison With PPSV23 in Japanese Elderly Male and Female Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: ASP3772 (subcutaneous)|BIOLOGICAL: ASP3772 (intramuscular)|BIOLOGICAL: PPSV23 (subcutaneous)|BIOLOGICAL: PPSV23 (intramuscular)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Temporization on the Peri-implant Soft Tissue of Immediate Implants: Randomized Controlled Clinical Trial
Status: UNKNOWN
Conditions: Dental Restoration, Temporary
Interventions: PROCEDURE: Immediate Implants|PROCEDURE: temporary restoration|PROCEDURE: final restoration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the Treatment of Primary Membranous Nephropathy: A Randomized Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: Efficacy and Safety
Interventions: DRUG: Rituximab combined with tacrolimus induction + rituximab maintenance|DRUG: Rituximab combined with tacrolimus induction + tacrolimus maintenance|DRUG: Glucocorticoid combined with cyclophosphamide induction + maintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Dexamethasone as Adjunctive Therapy to Ranibizumab in Subjects With Choroidal Neovascularization and Age-Related Macular Degeneration
Status: TERMINATED
Conditions: Subfoveal Choroidal Neovascularization|Age-Related Maculopathy
Interventions: DRUG: 700 ug dexamethasone|BIOLOGICAL: ranibizumab|OTHER: sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT