pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Do Wound Protectors Reduce Contamination in Total Shoulder Arthroplasty?
Status: ENROLLING_BY_INVITATION
Conditions: Cutibacterium Acnes
Interventions: OTHER: No Alexis orthopaedic protector|DEVICE: Alexis orthopaedic protector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Clinical Comparison of Two Marketed Reusable Cosmetic Contact Lenses
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: ACUVUE® DEFINE™ Vivid Style|DEVICE: LACELLE™ Sparkling Brown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: 7 Days Vs. 14 Days of Vonoprazan-based Triple Therapy for H. Pylori Eradication
Status: ACTIVE_NOT_RECRUITING
Conditions: Helicobacter Pylori Infection|Gastritis|Vonoprazan|Adolescents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Overall Survival in Participants With Unresectable Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular|Carcinoma|Neoplasms, Glandular and Epithelial|Neoplasms
Interventions: DRUG: Lenvatinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: RCT of Air Insufflation Versus Water Infusion Colonoscopy by Supervised Trainees
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: PROCEDURE: Colonoscopy for colorectal cancer screening|PROCEDURE: Water Infusion Colonoscopy|PROCEDURE: Air insufflation colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The ASsessment and Physiotherapy managEment of Ataxia in Children Following Surgical Resection of Posterior Fossa Tumour
Status: UNKNOWN
Conditions: Ataxia|Posterior Fossa Tumor
Interventions: OTHER: Therapist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiparametric Magnetic Resonance Imaging Versus Fine Needle Aspiration Cytology for Parotid Gland Neoplasms
Status: UNKNOWN
Conditions: Parotid Neoplasm|Parotid Cancer
Interventions: DIAGNOSTIC_TEST: Multiparametric Magnetic Resonance Imaging|DIAGNOSTIC_TEST: Fine Needle Aspiration Cytology|DIAGNOSTIC_TEST: Clinical Evaluation|DIAGNOSTIC_TEST: Final Histopathological Diagnosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Feasibility of Polychromatic Light Emitting Diode System to Reduce Pain
Status: SUSPENDED
Conditions: Pain
Interventions: DEVICE: UVL1000 Treatment Station|DRUG: Normal Saline 0.9% Infusion Solution Bag|DEVICE: Peripheral Catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Safety and Immunogenicity of Simultaneously Administration of sIPV and DTaP
Status: COMPLETED
Conditions: Vaccination
Interventions: BIOLOGICAL: Sabin-IPV and DTaP|BIOLOGICAL: Sabin-IPV|BIOLOGICAL: DTaP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Open Study to Investigate the Safety and Efficacy of Optivate® in Haemophilia A Patients Undergoing Surgery.
Status: COMPLETED
Conditions: Haemophilia A
Interventions: BIOLOGICAL: Optivate® (Human Coagulation Factor VIII)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: ABT-378/Ritonavir and Efavirenz in HIV-Infected Patients Who Have Taken More Than One Protease Inhibitor in the Past
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Lopinavir/Ritonavir|DRUG: Efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study Evaluating ACR325 in Parkinson's Disease Patients
Status: COMPLETED
Conditions: Parkinson's Disease|Tolerability
Interventions: DRUG: ACR325|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NSAIDs Added to Anti-TNF Therapy Versus Anti-TNF Therapy Alone on Progression of Structural Damage in Ankylosing Spondylitis
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: BIOLOGICAL: Golimumab|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mailed Reminders Plus Fecal Immunochemical Testing
Status: COMPLETED
Conditions: Colorectal Cancer Screening|Colorectal Cancer
Interventions: OTHER: Mailed Reminders with Fecal Immunochemical Testing kits|OTHER: Reminder letter only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effects of Post Isometric Relaxation With Scapular Stabilization Exercises
Status: COMPLETED
Conditions: Upper Cross Syndrome
Interventions: OTHER: Post-isometric relaxation and Conventional treatment|OTHER: Conventional Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction Study of ALXN2050 With Fluconazole and Rifampin in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ALXN2050|DRUG: Fluconazole|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Efficacy, Safety and Toleration of CT327 Ointment in Patients With Psoriasis Vulgaris
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: CT327 0.05%|DRUG: CT327 0.1%|DRUG: CT327 0.5%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EEG Monitoring for PERFormance Anticipation
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Electroencephalography (EEG) multi-sensor|OTHER: Magnetoencephalography (MEG)|OTHER: Behavioral Measures|OTHER: Reaction time measurement|OTHER: Assessment of physical performance|OTHER: Electrooculogram (EOG)|OTHER: Electromyogram (EMG)|OTHER: Electrocardiogram with 3 leads|OTHER: Electrodermogram (EDG)|OTHER: Consumption of O2 (VO2)|OTHER: Production of CO2 (VCO2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Radiation Therapy With or Without Goserelin and Cyproterone in Treating Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: cyproterone acetate|DRUG: goserelin acetate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Crossover Pharmacokinetic (PK) Study of 5 and 10 mg Corplex™ Donepezil TDS Compared to 10 mg Aricept® in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: COMBINATION_PRODUCT: Donepezil TDS|DRUG: Aricept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Automated Video-Assisted Smoking Treatment for People Living With HIV
Status: RECRUITING
Conditions: Smoking Cessation
Interventions: DRUG: Nicotine patch|BEHAVIORAL: Counseling|DRUG: Nicotine lozenge|BEHAVIORAL: Smartphone-delivered automated treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Synbiotic Therapy on Intestinal Microbiota and Insulin Resistance in Obesity
Status: COMPLETED
Conditions: Obesity|Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: Synbiotic (Rillus)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Relationship Between Bruxism and Tryptophan Metabolites
Status: COMPLETED
Conditions: Bruxism|Anxiety State|Tryptophan Metabolism Alterations
Interventions: DIAGNOSTIC_TEST: Metobolites serum level measurement|BEHAVIORAL: Anxiety and stress level measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Pemetrexed/Cisplatin With or Without Bevacizumab in Brain Metastases From Non Squamous Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non Squamous Non-small Cell Lung Cancer|Brain Metastases|Bevacizumab
Interventions: DRUG: Pemetrexed/cisplatin|DRUG: Bevacizumab and Pemetrexed/cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Antibiotic Prescribing Practices in Mexican Primary Care Clinics
Status: COMPLETED
Conditions: Acute Respiratory Tract Infections
Interventions: BEHAVIORAL: Computer kiosk Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Tralement Versus a Fixed-dose Trace Element Combination Product of Zinc, Copper, and Selenious Acid to Evaluate Product Safety in Adult Patients Requiring Long-term Parenteral Nutrition
Status: NOT_YET_RECRUITING
Conditions: Manganese Safety in Adults
Interventions: DRUG: Tralement|DRUG: Fixed-dose trace element combination product of zinc, copper, and selenious acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Citalopram Treatment in Acute Stroke
Status: COMPLETED
Conditions: Stroke, Ischemic
Interventions: DRUG: Citalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: What Influences Physicians' Decisions - Statistics or Stories?
Status: WITHDRAWN
Conditions: Prescribing Tendencies
Interventions: BEHAVIORAL: Guideline|BEHAVIORAL: Cost|BEHAVIORAL: Victim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Clinical Study Evaluating the Safety and Efficacy of Anti-HER2-CAR-T Cells Injection in Patients With Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor
Interventions: BIOLOGICAL: Intravenous infusion anti-HER2-CAR-T cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel (Phyxol) and Cisplatin as First-line Chemotherapy for Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Paclitaxel (Phyxol) , Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Acupuncture on Abdominal Pain-related Intestinal Flora in Patients With Crohn's Disease
Status: COMPLETED
Conditions: Crohn Disease
Interventions: OTHER: acupuncture|OTHER: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metreleptin in Anorexia Nervosa
Status: NOT_YET_RECRUITING
Conditions: Anorexia Nervosa
Interventions: DRUG: Metreleptin|DRUG: Sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Head-to-Head Harmonization of Tau Tracers in Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: 18F-Flortaucipir radiopharmaceutical|DRUG: 18F-MK-6240 radiopharmaceutical|DRUG: Amyloid-β radiopharmaceutical (11C-PiB or 18F-Florbetaben or 18F-NAV-4694 or 18F-Florbetapir)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Examining the Long-term Safety of Insulin Aspart When Used as a Part of the Treatment for Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin aspart|DRUG: insulin NPH
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study for Evaluating the Efficacy of Ciprofol in Patients Under Narcotic Sleep With Chronic Insomnia
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Insomnia
Interventions: DRUG: ciprofol|DRUG: medium/long chain fat emulsion injection (C8-24Ve)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Incisional Hernia After Renal Transplantation
Status: RECRUITING
Conditions: Incisional Hernia|Kidney Transplantation|Postoperative Complications
Interventions: DEVICE: ProGrip™ Self-Gripping Polyester Mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mixture Nitrous Oxide - Oxygen 50-50% in Transrectal Prostate Biopsy Guided by Ultrasound
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Nitrous Oxide NO|OTHER: O2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intraoperative Fluid Management of Liposuction , Cardiometry Versus Rohrich Formula
Status: COMPLETED
Conditions: Lipodystrophy
Interventions: DEVICE: Electrical Cardiometry (EC) ICON|OTHER: Rohrich formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Study the Peripheral Effect of Botulinum Toxin-A (Botox-A) on Experimentally Induced Cutaneous Pain in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Botox (Allergan Inc., US)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: GS-5734 to Assess the Antiviral Activity, Longer-Term Clearance of Ebola Virus, and Safety in Male Ebola Survivors With Evidence of Ebola Virus Persistence in Semen
Status: COMPLETED
Conditions: Ebola
Interventions: DRUG: GS-5734|OTHER: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity Bridge Between an Investigational Monovalent Vaccine and the Equivalent Component of Gardasil (V501) a Quadrivalent Vaccine (V501-012)(COMPLETED)
Status: COMPLETED
Conditions: Cervical Cancer|Genital Warts
Interventions: BIOLOGICAL: V501, Gardasil, human papillomavirus (type 6, 11, 16, 18) recombinant vaccine / Duration of Treatment: 4 years
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: ParKinWalk: Physical Activity and Long Group-walking for Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease|Healthy Aging
Interventions: OTHER: Exercise program followed by long walk in group|OTHER: Exercise program followed by long walk in group (controls)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pragmatic Randomized Controlled Trial of Pharmacopuncture Therapy for Adhesive Capsulitis : A Pilot Study
Status: COMPLETED
Conditions: Adhesive Capsulitis
Interventions: PROCEDURE: pharmacopuncture therapy|PROCEDURE: physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Among Different Doses of Ephedrine During Elective Cesarean Section Under Subarachnoid Block.
Status: COMPLETED
Conditions: Anesthesia|Cesarean Section Complications|Subarachnoid Block
Interventions: DRUG: Ephedrine 5mg|DRUG: Ephedrine 10mg|DRUG: Ephedrine 15mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Behavioral and Drug Treatment of Overactive Bladder in Men
Status: COMPLETED
Conditions: Overactive Bladder|Lower Urinary Tract Symptoms
Interventions: BEHAVIORAL: Behavioral training|DRUG: Tolterodine + tamsulosin|OTHER: Combined Behavioral + Drug Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketone Plasma Kinetics After Oral Intake Of Different MCT
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: 2.5% protein|DIETARY_SUPPLEMENT: protein 5%|DIETARY_SUPPLEMENT: protein 10%|DIETARY_SUPPLEMENT: protein 15%|DIETARY_SUPPLEMENT: A2: Peptamen 1.5 Vanilla without Breakfast|DIETARY_SUPPLEMENT: B2: only breakfast (no product)|DIETARY_SUPPLEMENT: C2: 5% protein with breakfast|DIETARY_SUPPLEMENT: D2: 5% protein 30 min before breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Light on the Choroid and Pupil
Status: COMPLETED
Conditions: Emmetropia|Myopia
Interventions: OTHER: White Light therapy|OTHER: Blue light therapy|OTHER: Red light therapy|OTHER: Darkness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of the Effects of Apixaban on Thrombin Generation in Patients With de Novo Multiple Myeloma
Status: NOT_YET_RECRUITING
Conditions: Multiple Myeloma|Total Knee Replacement
Interventions: PROCEDURE: Blood sampling|DRUG: Apixaban
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Tislelizumab for the Treatment of Recurrent Mismatch Repair Deficient Endometrial Cancer
Status: TERMINATED
Conditions: Lynch Syndrome|Recurrent Endometrial Carcinoma|Recurrent Endometrial Clear Cell Adenocarcinoma|Recurrent Uterine Corpus Carcinosarcoma|Mismatch Repair Deficiency|Recurrent Endometrial Cancer|Metastatic Endometrial Cancer
Interventions: PROCEDURE: Biopsy|DRUG: Carboplatin|DRUG: Paclitaxel|BIOLOGICAL: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modulation Effects of Baduanjin Exercise on Subjective Cognitive Decline
Status: RECRUITING
Conditions: Cognitive Decline
Interventions: OTHER: Baduanjin Exercise|OTHER: Cognitive Fitness Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fabulous Fibre Study - Effect of Wheat Bran Extract on Gut and General Health in Healthy Aging Subjects (FFS)
Status: COMPLETED
Conditions: Hypercholesterolemia|Flatulence|Intestinal Diseases
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Fibre supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the "Americans in Motion - Healthy Interventions" Project
Status: COMPLETED
Conditions: Physical Activity|Diet|Mental Health
Interventions: BEHAVIORAL: Enhanced Office|BEHAVIORAL: Conventional Office|BEHAVIORAL: AIM-HI program with enhanced feedback|BEHAVIORAL: AIM-HI program and regular feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose:
Clinical trial: FatMax Training on Metabolic and Epigenetic Parameters
Status: NOT_YET_RECRUITING
Conditions: Overweight and Obesity|Body Weight Changes
Interventions: OTHER: FatMAx training intervention|OTHER: FatMax and physical endurance exercise intervention|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Lipitor Phase 4 Clinical Trial in Hypercholesteremia Patients With Yellow Coronary Plaque
Status: COMPLETED
Conditions: Hypercholesteremia|Coronary Artery Disease
Interventions: DRUG: atorvastatin, Lipitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychometric Properties of IntelliSpace Cognition
Status: COMPLETED
Conditions: Cognitive Functioning of Healthy Individuals
Interventions: DEVICE: IntelliSpace Cognition (ISC)|DIAGNOSTIC_TEST: Paper-Pencil Tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: PALBOCICLIB + PD-0325901 for NSCLC & Solid Tumors
Status: COMPLETED
Conditions: KRAS Mutant Non-Small Cell Lung Cancer|Solid Tumors
Interventions: DRUG: Palbociclib|DRUG: PD-0325901
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotic Intervention for Stress and Cognition
Status: COMPLETED
Conditions: Stress|Cognition
Interventions: DIETARY_SUPPLEMENT: Probiotics|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Quadratus Lumborum Block : Effect on Acute Pain and Quality of Recovery After Laparoscopic Renal Surgery
Status: COMPLETED
Conditions: Laparoscopic Renal Surgery|Pain Management|Nerve Block
Interventions: PROCEDURE: single-injection QLB(quadratus lumborum block)|DEVICE: Philip CX50 Ultrasound Scanner|DEVICE: PAJUNK StimuLong|DRUG: single dose ropivacaine|DRUG: Morphine given as IPCA(intravenous patient controlled analgesia)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study in Healthy Male Volunteers to Look at How the Test Medicine GLPG1690 is Taken up by the Body When Doses of Itraconazole and Voriconazole Are Given to Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG1690|DRUG: Itraconazole|DRUG: Voriconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PCD Versus RCD for the Treatment of Patients With Waldenstrom's Macroglobulinemia
Status: UNKNOWN
Conditions: Treatment
Interventions: DRUG: rituximab /Dexamethasone/cyclophosphamide|DRUG: Velcade/Dexamethasone/cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of CD10367 in Psoriasis Vulgaris
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: CD10367 3% Solution - Non-desquamated zone|DRUG: CD10367 1% Solution - Non-desquamated zone|DRUG: CD10367 solution placebo - Non-desquamated zone|DRUG: Betneval ointment - Non-desquamated zone|DRUG: CD10367 3% Solution - Desquamated zone|DRUG: CD10367 solution placebo - Desquamated zone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Effects of Operating Room Virtual Tour
Status: COMPLETED
Conditions: Preoperative Care|Anxiety|Emergence Delirium|Postoperative Complications
Interventions: BEHAVIORAL: a 360-degree VR video tour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Examining Outcome Expectancies and Behavioral Reinforcers Among Young Adult Smokers
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Expectancy Challenge|BEHAVIORAL: Expectancy Challenge + Behavioral Activation|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study Evaluating Efficacy and Safety of T3D-959 in Mild-to-moderate AD Subjects
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: 15mg T3D-959|DRUG: 30 mg T3D-959|DRUG: 45 mg T3D-959|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Planning Treatment for Oesophago-gastric Cancer: a Maintenance Therapy Trial
Status: RECRUITING
Conditions: Adenocarcinoma of the Oesophagus|Adenocarcinoma of the Gastro-oesophageal Junction|Adenocarcinoma of the Stomach
Interventions: DRUG: Capecitabine|DRUG: MEDI4736|DRUG: Trastuzumab|DRUG: Rucaparib|DRUG: Ramucirumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Experience of High-frequency Repetitive Transcranial
Status: COMPLETED
Conditions: Chronic Schizophrenia
Interventions: DEVICE: Magstim RAPID2 neuromagnetic stimulator (Magstim) with an "8"-type coil|DEVICE: Magstim RAPID2 neuromagnetic stimulator (Magstim) with an "8"-type coil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Demonstrate the Efficacy and Safety of Convatec ConvaFoam™ Silicone, ConvaFoam™ Border and ConvaFoam™ Non-adhesive Dressings to Protect Against Skin Breakdown
Status: NOT_YET_RECRUITING
Conditions: Skin Breakdown
Interventions: DEVICE: ConvaFoam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Oxytocin in Cesarean Delivery
Status: UNKNOWN
Conditions: Post Partum Hemorrhage
Interventions: DRUG: Oxytocin versus oxytocin-ergometrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immune Response After Human Papillomavirus Vaccination in Patients With Autoimmune Disease
Status: COMPLETED
Conditions: Juvenile Idiopathic Arthritis|Systemic Lupus Erythematosus|Juvenile Dermatomyositis
Interventions: OTHER: Human papilloma virus vaccine (cervarix)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of CodaLytic, an Intratumoral Oncolytic Virus, in Patients With Breast Cancer
Status: WITHDRAWN
Conditions: Breast Neoplasms|Neoplasm Metastasis
Interventions: BIOLOGICAL: CodaLytic
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Substudy of the TDE-PH-304 Protocol
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: UT-15C SR|DRUG: treprostinil diethanolamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Inter-reader Reliability Using Images From Subjects With Alzheimer's Disease (AD) or Mild Cognitive Impairment (MCI)
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: florbetapir F 18
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Low Concentration Atropine in the Prevention of Myopia in Children.
Status: RECRUITING
Conditions: Myopia, Progressive
Interventions: DRUG: low concentration atropine (0.01%)|DRUG: low concentration atropine (0.02%)|DRUG: low concentration atropine (0.04%)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Long-Term Safety Extension Trial of Ferric Citrate in Patients With End-Stage Renal Disease (ESRD) on Dialysis
Status: COMPLETED
Conditions: End Stage Renal Disease|Kidney Failure|Renal Failure|Hyperphosphatemia|ESRD
Interventions: DRUG: ferric citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lakeshore Examination of Activity and Disability Exercise Response Study
Status: COMPLETED
Conditions: Multiple Sclerosis|Stroke
Interventions: BEHAVIORAL: Movement to Music|BEHAVIORAL: Adapted Yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 2 Window Study of SAR439859 (Amcenestrant) Versus Letrozole in Post-menopausal Patients With ER+, HER2- Pre-operative Post-menopausal Primary Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Amcenestrant (SAR439859)|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spinal Bupivacaine/Morphine in Laparoscopic Gastro-intestinal Surgery
Status: COMPLETED
Conditions: Spinal Bupivacaine/Morphine in Laparoscopic Surgery
Interventions: DRUG: Spinal injection bupivacaine/morphine|DRUG: subcutaneum injection lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients
Status: COMPLETED
Conditions: Intracranial Aneurysm|Brain Edema|Scoliosis|Surgery
Interventions: DRUG: Phenylephrine|DRUG: Epinephrine|OTHER: Albumin|OTHER: Voluven|OTHER: Normal Saline|OTHER: Packed Red Blood Cells|DEVICE: FloTrac Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase II: Pembrolizumab/Carboplatin/Taxol in Epithelial Ovary Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minocycline, Acetylsalicylic Acid or Pramipexole vs Placebo in Patients With Schizophrenia or Schizoaffective Disorder
Status: UNKNOWN
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: minocycline|DRUG: pramipexole|DRUG: acetylsalicylic acid|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: "Core Stability" Exercises to Improve Sitting Balance in Stroke Patients
Status: COMPLETED
Conditions: Stroke|Cerebral Stroke|Cerebrovascular Accident
Interventions: OTHER: Core stability|OTHER: Standard Physiotherapy Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virologic and Immunologic Activity of Continued Lamivudine (3TC) vs Delavirdine (DLV) in Combination With Indinavir (IDV) and Zidovudine (ZDV) or Stavudine (d4T) in 3TC-Experienced Subjects
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Indinavir sulfate|DRUG: Delavirdine mesylate|DRUG: Lamivudine|DRUG: Stavudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy Followed by Surgery in Treating Patients With Early-Stage Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: biopsy|PROCEDURE: fine-needle aspiration|RADIATION: accelerated partial breast irradiation|RADIATION: image-guided radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cixutumumab and Temsirolimus in Treating Younger Patients With Solid Tumors That Have Recurred or Not Responded to Treatment
Status: COMPLETED
Conditions: Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: cixutumumab|DRUG: temsirolimus|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Thoracolumbar Interfascial Plane Block for Postoperative Analgesia After Herniated Lumbar Disc Surgery
Status: UNKNOWN
Conditions: Postoperative Analgesia After Disc Surgery
Interventions: PROCEDURE: Thoracolumber interfascial plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of AposTherapy on the Level of Pain, Function and Quality of Life in Patients With Neuro-muscular and Neurological Disorders
Status: UNKNOWN
Conditions: Osteoarthritis|Spinal Diseases|Ligament Rupture|Lower Extremity Fracture|Neurological Disorders
Interventions: DEVICE: AposTherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy of Laser Debridement on Pain and Bacterial Load in Chronic Wounds
Status: COMPLETED
Conditions: Wound Open|Chronic Venous Hypertension (Idiopathic) With Ulcer|Diabetic Foot Ulcer
Interventions: DEVICE: Erbium:Yttrium-Aluminum-Garnet (Er:YAG) Laser Debridement|PROCEDURE: Scalpel/Curette Debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CD34+ Selected Stem Cell for Poor Graft Function or Graft Failure
Status: NOT_YET_RECRUITING
Conditions: Graft Failure|Poor Graft Function
Interventions: DEVICE: CD34+ Selected Donor Cell Boost|PROCEDURE: Blood Stem Cell Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subcuticular Suture Versus Synthetic Glue in Thyroidectomy Incision
Status: COMPLETED
Conditions: Goiter|Thyroid Neoplasms|Parathyroid Pathologies
Interventions: DEVICE: Octylcyanoacrylate (Dermabond)|DEVICE: Subcuticular reabsorbable suture (Caprosyn)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures, and Discovery of Therapeutic Targets
Status: RECRUITING
Conditions: Meniere's Disease|Enlarged Vestibular Aqueduct Syndrome|Autoimmune Inner Ear Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open-Label Safety Study of Three-Antigen Leishmania Polyprotein With Adjuvant MPL-SE in Healthy Adults in India
Status: COMPLETED
Conditions: Visceral Leishmaniasis|Post-kala-azar Dermal Leishmaniasis
Interventions: BIOLOGICAL: Leish-111f + MPL-SE Adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of COVAC-1, a COVID-19 Vaccine, in Generally Healthy Adults
Status: WITHDRAWN
Conditions: Severe Acute Respiratory Syndrome Coronavirus 2
Interventions: BIOLOGICAL: COVAC-1|BIOLOGICAL: Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Concomitant CC and E2 Versus CC Alone in Ovulation Induction
Status: UNKNOWN
Conditions: Infertility|Anovulation
Interventions: DRUG: Clomiphene citrate and Estradiol|DRUG: Clomiphene citrate and Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Hepatic Arterial Infusion Combined With Apatinib and Camrelizumab Versus Apatinib and Camrelizumab for C-staged Hepatocellular Carcinoma in BCLC Classification
Status: RECRUITING
Conditions: C-staged Hepatocellular Carcinoma in BCLC Classification
Interventions: COMBINATION_PRODUCT: Hepatic Arterial Infusion combined with Apatinib and Camrelizumab|COMBINATION_PRODUCT: Apatinib combined with Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Transcranial Photobiomodulation in Autism Spectrum Disorder
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DEVICE: Transcranial Photobiomodulation (tPBM)|DEVICE: Placebo/ Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Mastoid Condition on Results of Endoscopic Management of Cholesteatoma
Status: RECRUITING
Conditions: Cholesteatoma of Attic|Cholesteatoma, Middle Ear
Interventions: PROCEDURE: Transcanal Endoscopic removal of atticoantral cholesteatoma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MDMA-Assisted Psychotherapy for Treatment Resistant PTSD in Adolescents
Status: NOT_YET_RECRUITING
Conditions: PTSD, Post Traumatic Stress Disorder|Adolescents|Psychotherapy
Interventions: DRUG: MDMA|BEHAVIORAL: Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Telecare-based Intervention in Reducing Stress Level of Informal Caregivers of Community-dwelling Older Adults
Status: COMPLETED
Conditions: Telemedicine
Interventions: OTHER: Telecare-based intervention program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Screening for Neonatal Jaundice With a Mobile Health Device: a Validation Study in Oaxaca, Mexico.
Status: COMPLETED
Conditions: Jaundice, Neonatal
Interventions: DEVICE: Screening for neonatal jaundice with a mobile health device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: The Impact of Supplementation With Novel Prototype Nutrition Bar on Nitric Oxide Bioavailability and Measures of Athlete Performance
Status: COMPLETED
Conditions: Exercise Performance
Interventions: OTHER: Active Nitrate Bar|OTHER: Placebo Bar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase I, Randomized, Double-Blind, Single-Dose, Dose Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of MEDI-557
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: MEDI-557|BIOLOGICAL: MEDI-557|BIOLOGICAL: MEDI-557|BIOLOGICAL: MEDI-557
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gene Therapy for Metachromatic Leukodystrophy (MLD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Lysosomal Storage Disease|Metachromatic Leukodystrophy
Interventions: GENETIC: OTL-200 Gene Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Intravenous or Subcutaneous Dosing of Sotatercept (ACE-011) in Patients With End-Stage Kidney Disease on Hemodialysis
Status: COMPLETED
Conditions: Anemia|Kidney Failure, Chronic
Interventions: BIOLOGICAL: Sotatercept|BIOLOGICAL: Sotatercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrical Stimulation for Hemiplegic Shoulder Pain
Status: COMPLETED
Conditions: Stroke|Shoulder Pain
Interventions: DEVICE: Intramuscular Electrical Stimulator|OTHER: Outpatient Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Imaging and Ultrasound Comparison With Load Evaluation
Status: RECRUITING
Conditions: Muscular Dystrophy, Facioscapulohumeral
Interventions: DIAGNOSTIC_TEST: Muscle ultrasound with surface electromyography and dynamometry|DIAGNOSTIC_TEST: MRI scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Olaparib and Radiotherapy in Inoperable Breast Cancer
Status: COMPLETED
Conditions: Locally Advanced Malignant Neoplasm|Inflammatory Breast Carcinoma|Triple-Negative Invasive Breast Carcinoma
Interventions: RADIATION: radiotherapy|DRUG: olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zanubrutinib and CAR T-cell Therapy for the Treatment of Recurrent or Refractory Aggressive B-cell Non-Hodgkin's Lymphoma or Transformed Indolent B-cell Lymphoma
Status: RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation|EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified|High Grade B-Cell Lymphoma, Not Otherwise Specified|Large B-Cell Lymphoma With IRF4 Rearrangement|Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type|Recurrent Aggressive B-Cell Non-Hodgkin Lymphoma|Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified|Recurrent High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements|Recurrent Intravascular Large B-Cell Lymphoma|Recurrent Primary Mediastinal (Thymic) Large B-Cell Lymphoma|Recurrent T-Cell/Histiocyte-Rich Large B-Cell Lymphoma|Recurrent Transformed B-Cell Non-Hodgkin Lymphoma|Refractory Aggressive B-Cell Non-Hodgkin Lymphoma|Refractory Diffuse Large B-Cell Lymphoma, Not Otherwise Specified|Refractory High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements|Refractory Intravascular Large B-Cell Lymphoma|Refractory Primary Mediastinal (Thymic) Large B-Cell Lymphoma|Refractory T-Cell/Histiocyte-Rich Large B-Cell Lymphoma|Refractory Transformed B-Cell Non-Hodgkin Lymphoma
Interventions: BIOLOGICAL: Chimeric Antigen Receptor T-Cell Therapy|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|DRUG: Zanubrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Carbon Ion Versus Photon Radiotherapy for Locally Advanced, Unresectable Pancreatic Cancer
Status: WITHDRAWN
Conditions: Locally Advanced Pancreatic Adenocarcinoma
Interventions: RADIATION: Carbon Ion Radiation Therapy (CIRT)|RADIATION: Intensity Modulated Radiation Therapy (IMRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Hormonal Contraceptives on Breast-milk Production and Infant Growth
Status: COMPLETED
Conditions: Underweight
Interventions: DEVICE: LNG-IUS|DEVICE: Implanon|DRUG: 30 mcg EE and 150 LNG oral contraceptive (Microvlar)|DEVICE: TCu380A copper-intrauterine device|DEVICE: TCu380A intrauterine device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Safety and Effectiveness of Adefovir Dipivoxil in the Treatment of HIV-Infected Patients
Status: COMPLETED
Conditions: Cytomegalovirus Infections|HIV Infections
Interventions: DRUG: Levocarnitine|DRUG: Adefovir dipivoxil|DRUG: Adefovir dipivoxil placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Fast Assessment of Stroke and Transient Ischemic Attack to Prevent Early Recurrence (FASTER)
Status: COMPLETED
Conditions: Transient Ischemic Attack|Stroke
Interventions: DRUG: Aspirin|DRUG: Clopidogrel|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Phase II, Open-Label Trial Evaluating GV1001 in Advanced Hepatocellular Carcinoma.
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: BIOLOGICAL: GV1001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Effect of the Study Drug Praluent (Alirocumab) on Neurocognitive Function When Compared to Placebo
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Praluent (Alirocumab)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sentinel Lymph Node Biopsy for Cutaneous Squamous Cell Carcinoma of the Head and Neck
Status: UNKNOWN
Conditions: Cutaneous Squamous Cell Carcinoma|Sentinel Lymph Node
Interventions: PROCEDURE: Sentinel Lymph Node Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT