pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Efficacy of Ultrasound Renal Denervation in Kidney Transplantation Patients With Uncontrolled Hypertension
Status: NOT_YET_RECRUITING
Conditions: Hypertension|Kidney Transplantation
Interventions: DEVICE: Paradise® ultrasound renal denervation system.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DEMAND - Multifactorial Study to Reduce Dementia in People With Type 2 Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus|Mild Cognitive Impairment
Interventions: DIETARY_SUPPLEMENT: mediterranean diet|BEHAVIORAL: individualized fitness program|OTHER: recommended modified pharmacological treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Problem-solving Therapy Offered Through a Web Platform on Levels of Stress
Status: UNKNOWN
Conditions: Stress, Psychological|Behavior|Occupational Stress|Mental Health Wellness 1
Interventions: OTHER: Problem Solving Therapy offered through a web platform|OTHER: Conventional web platform
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of an Adenovirus Serotype 26 Pre-fusion Conformation-stabilized F Protein (Ad26. RSV. preF) Based Respiratory Syncytial Virus (RSV) Vaccine in the Prevention of Lower Respiratory Tract Disease in Adults Aged 60 Years and Older
Status: COMPLETED
Conditions: Respiratory Syncytial Viruses|Lower Respiratory Tract Disease
Interventions: BIOLOGICAL: Adenovirus serotype 26 (Ad26)-based respiratory syncytial virus (RSV). preF|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Behavioral Economics to Improve Antihypertensive Therapy Adherence
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension|Medication Adherence
Interventions: BEHAVIORAL: Text Message|BEHAVIORAL: Behavior Economic Incentive|BEHAVIORAL: Text Message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: PN-943 in Adults With Moderate to Severe Active Ulcerative Colitis (UC)
Status: COMPLETED
Conditions: Ulcerative Colitis Chronic Moderate|Ulcerative Colitis Chronic Severe
Interventions: DRUG: PN-943|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: rTMS in the Prevention and Treatment of Postoperative Executive Dysfunction
Status: RECRUITING
Conditions: Executive Function Disorder|Functional Magnetic Resonance Imaging
Interventions: DEVICE: repetitive transcranial magnetic stimulation|DEVICE: pseudo repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study in Elderly Alzheimer's Patients to Assess Skin Tolerability, Irritation With 3, 7-Day Applications of DTP-System
Status: COMPLETED
Conditions: Irritation/Irritant
Interventions: DRUG: 350 mg Donepezil Transdermal Patch|DRUG: Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pasta and Other Durum Wheat-based Products: Effects on Post-prandial Glucose Metabolism
Status: COMPLETED
Conditions: Dietary Modification
Interventions: OTHER: Glucose|OTHER: Semolina soup|OTHER: Bread|OTHER: Penne (fresh)|OTHER: Penne (dry)|OTHER: Spaghetti (dry)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Examination of Differential Valuation of Leisure Items and Attention as Reinforcers in Children With Autism
Status: COMPLETED
Conditions: Autism
Interventions: BEHAVIORAL: Training trials|BEHAVIORAL: Progressive Ratio Session|BEHAVIORAL: Re-test|BEHAVIORAL: Pairing Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Effect of Fimasartan on Pharmacokinetics, and the Safety of Digoxin in Healthy Male Volunteers
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Digoxin + Fimasartan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial
Status: NOT_YET_RECRUITING
Conditions: Acute Lymphoblastic Leukaemia|Acute Leukemia of Ambiguous Lineage|Chronic Myeloid Leukemia|Chronic Myelomonocytic Leukemia|Myelodysplastic Syndrome|Acute Myeloid Leukemia
Interventions: DRUG: EBX-102|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Treatment of Halitosis With Photodynamic Therapy in Older Patients With Complete Denture
Status: COMPLETED
Conditions: Halitosis
Interventions: DEVICE: Treatment with tongue scraper|PROCEDURE: Hygiene procedures for the mucosa and dentures|RADIATION: Photodynamic Therapy|PROCEDURE: Hygiene procedures for the mucosa and dentures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Primary Cervical Cancer Screening by Self-sampling HPV Test
Status: ACTIVE_NOT_RECRUITING
Conditions: Human Papillomavirus Infection|Cervical Cancer|Negative For Intraepithelial Lesion Or Malignancy|Atypical Squamous Cells of Undetermined Significance|Atypical Squamous Cells, Cannot Rule Out High-grade Squamous Intraepithelial Lesion|Cervical Squamous Intraepithelial Lesion|Low-Grade Squamous Intraepithelial Lesions|High-Grade Squamous Intraepithelial Lesions|Cervical Intraepithelial Neoplasia Grade I|Cervical Intraepithelial Neoplasia Grade II|Cervical Intraepithelial Neoplasia, Grade III|Atypical Glandular Cells|Atypical Glandular Cells Not Otherwise Specified|Atypical Glandular Cells, Favor Neoplastic|Cervical Squamous Cell Carcinoma|Adenocarcinoma in Situ|Cervical Adenocarcinoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Lacosamide 200 mg Twice a Day (Bid) on Single Dose Warfarin 25 mg in Healthy Males
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: Lacosamide|OTHER: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Antioxidant Effects of Melatonin in Preterm
Status: COMPLETED
Conditions: Newborn Morbidity|Oxidative Stress|Pre-Term|Melatonin Deficiency
Interventions: DIETARY_SUPPLEMENT: Melatonin drops|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rifaximin and Misoprostol Combination Therapy for Healing of Small Bowel Ulcers in Aspirin Users
Status: UNKNOWN
Conditions: Small Bowel Disease|Rifaximin
Interventions: DRUG: Rifaximin|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Continuous Versus Interval Exercise Training in Asthmatic Patients
Status: UNKNOWN
Conditions: Asthma
Interventions: OTHER: Continuous Exercise Training|OTHER: Interval Exercise Training|BEHAVIORAL: Education Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hidroxicloroquina With Azitromicina Versus Hidroxicloroquina and Placebo Int Patients With Mild COVID-19
Status: UNKNOWN
Conditions: Covid19
Interventions: DRUG: Hydroxychloroquine with Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Test Retest Reliability of OA and OH
Status: COMPLETED
Conditions: Analgesia|Pain Catastrophizing|Pain
Interventions: BEHAVIORAL: Medoc cutaneous probe|BEHAVIORAL: Quantitative sensory testing|BEHAVIORAL: Computer tasks
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: fluconazole|DRUG: itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Utility of Preanestes@s, a Web Based Application for Preoperative Assessment
Status: RECRUITING
Conditions: Mobile Applications|Internet-Based Intervention|Ambulatory Surgical Procedures|Preoperative Period
Interventions: OTHER: Web based preoperative assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Impact of Pleural Manometry on Chest Discomfort After Therapeutic Thoracentesis
Status: COMPLETED
Conditions: Pleural Effusion
Interventions: OTHER: Manometry-guided thoracentesis|OTHER: Symptom-guided thoracentesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Use of Airway Pressure Release Ventilation in Morbidly Obese Patients Undergoing Open Heart Surgery
Status: RECRUITING
Conditions: Pulmonary Atelectasis|Morbid Obesity|Pulmonary Complication
Interventions: DEVICE: Use Of APRV mode of Ventilation|DEVICE: Use of conventional Synchronized Intermittent Mandatory Ventilation (SIMV) volume control mode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Realistic in Generation of HEp-2 Cell Images Using Latent Diffusion Models: a Multi-center Visual Turing Test
Status: NOT_YET_RECRUITING
Conditions: Anti-nuclear Antibody|Visual Turing Tests|Artifical Intelligence
Interventions: BEHAVIORAL: referring to the results of AI model output
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Validation of CMR Against Invasive Haemodynamics in Patients With HFpEF
Status: COMPLETED
Conditions: Heart Failure With Normal Ejection Fraction
Interventions: DIAGNOSTIC_TEST: Comprehensive Cardiovascular magnetic resonance (CMR)|DIAGNOSTIC_TEST: Blood sampling|DIAGNOSTIC_TEST: TTE (EchoErgo)|DIAGNOSTIC_TEST: Invasive pressure-volume (PV) Loops|DIAGNOSTIC_TEST: Left ventricular (LV) biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SARC031: MEK Inhibitor Selumetinib (AZD6244) in Combination With the mTOR Inhibitor Sirolimus for Patients With Malignant Peripheral Nerve Sheath Tumors
Status: COMPLETED
Conditions: Malignant Peripheral Nerve Sheath Tumors|Neurofibromatosis 1
Interventions: DRUG: Selumetinib|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Time Course Adaptations Using Deuterated Creatine (D3Cr) Method
Status: COMPLETED
Conditions: Sarcopenia
Interventions: BEHAVIORAL: Resistance Training|BEHAVIORAL: Successful Aging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dopamine Receptor Contributions to Prediction Error and Reversal Learning in Anorexia Nervosa
Status: ACTIVE_NOT_RECRUITING
Conditions: Anorexia Nervosa
Interventions: DRUG: amisulpride|DRUG: bromocriptine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: SI + CC Versus 3:1 C:V Ratio During Neonatal CPR
Status: COMPLETED
Conditions: Heart Arrest|Birth Asphyxia|Bradycardia
Interventions: PROCEDURE: CC+SI|PROCEDURE: 3:1 C:V
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laminaria Compared to Dilapan-S for Cervical Preparation Before Dilation and Evacuation at 18-24 Weeks of Gestation
Status: COMPLETED
Conditions: Second Trimester Abortion
Interventions: DEVICE: Laminaria|DEVICE: Dilapan-S
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Norepinephrine and Dopamine on Radial Forearm Free Flap Tissue Oxygen Pressure and Microdialysate Metabolite Measurements
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: Dopamine|DRUG: Norepinephrine|OTHER: no medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept Study of PEMF (Pulsed Electromagnetic Field) Therapy in Subjects With Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Provant Therapy System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-domain Psychoeducation Self-management Program for Adults With MDD in Singapore
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: BEHAVIORAL: Multi-domain Psychoeducation Self-management Programme|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase 2b/3 Study of XAF5 Ointment for Steatoblepharon (Undereye Bags)
Status: COMPLETED
Conditions: Steatoblepharon
Interventions: DRUG: XAF5 (concentration A: 0.1%)|DRUG: XAF5 (concentration B: 0.035%)|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Experimental Exposure to Air Pollutants and Sympathetic Nerve Activity in Human Subjects
Status: UNKNOWN
Conditions: Cardiovascular Morbidity
Interventions: OTHER: ultrafine particles|OTHER: ultrafine particles and ozone|OTHER: clean air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Bioavailability Study of Sitagliptin/Metformin 50 mg/1000 mg Tablets in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Bioequivalence|Type 2 Diabetes
Interventions: DRUG: Sitagliptin/metformin hydrochloride (HCl) 50/1000 mg film-coated tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Flovent in Patients With Eosinophilic Esophagitis
Status: COMPLETED
Conditions: Eosinophilic Esophagitis
Interventions: DRUG: Flovent|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of the 15 and 30 Acquisition Angle Breast Tomosynthesis Mammography for Breast Abnormalities
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DEVICE: 3D mammograpgy system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Extracorporeal Cytokine Hemoadsorption in Septic Shock in Critically Ill Cirrhotics
Status: UNKNOWN
Conditions: Septic Shock
Interventions: DRUG: Extracorporeal Cytokine hemadsorption therapy|DRUG: Standard Medical Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decompressive Craniectomy Combined With Hematoma Removal to Treat ICH
Status: UNKNOWN
Conditions: Intracranial Hemorrhages
Interventions: PROCEDURE: Decompressive Craniectomy|PROCEDURE: non-Decompressive Craniectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and Safety Evaluation of L-tetrahydropalmatine (l-THP) With Cocaine Exposure in People With a History of Cocaine Use
Status: COMPLETED
Conditions: Cocaine Use
Interventions: DRUG: l-THP (l-tetrahydropalmatine)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Novel Therapies for Muco-Obstructive Lung Diseases: Testing the Transnasal Pulmonary Delivery Device in COPD/CB Subjects
Status: WITHDRAWN
Conditions: COPD|Chronic Bronchitis
Interventions: DEVICE: tPAD|DEVICE: 7% hypertonic saline (510K approved as a device)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Bevacizumab Plus Sorafenib for the Third-line Treatment in Metastatic Renal Cancer Patients
Status: UNKNOWN
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: Bevacizumab|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Acceptability Study of Intravaginal Administration of LABTHERA-001 Capsules in Healthy Women
Status: RECRUITING
Conditions: Bacterial Vaginosis|Vaginal Disease|Bacterial Infections|Vaginitis|Infection, Bacterial
Interventions: DRUG: Experimental: Low dose LABTHERA-001 capsule|DRUG: Experimental: Medium dose LABTHERA-001 capsule|DRUG: Experimental: High dose LABTHERA-001 capsule|OTHER: Placebo Comparator: Low dose Placebo capsule|OTHER: Placebo Comparator: Medium dose Placebo capsule|OTHER: Placebo Comparator: High dose Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Icotinib Combined With WBRT For NSCLC Patients With Brain Metastases and EGFR Mutation
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer|Brain Metastases
Interventions: DRUG: icotinib|RADIATION: Whole brain radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Panitumumab Chemoradiotherapy Chemotherapy for Squamous Cancer of the Head and Neck
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Panitumumab|DRUG: Carboplatin|DRUG: Paclitaxel|RADIATION: Intensity Modulated Radiation Therapy|DRUG: 5-Fluorouracil|DRUG: Docetaxel|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incobotulinumtoxin A and Yoga-like Isometric Exercise in Adolescent Idiopathic Lumbar Scoliosis
Status: RECRUITING
Conditions: Scoliosis Idiopathic|Scoliosis; Adolescence|Scoliosis; Lumbar Region
Interventions: DRUG: Botulinum toxin type A|BEHAVIORAL: Isometric Yoga-like exercise|BEHAVIORAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of 20 mg Omeprazole Capsules in Indonesia Healthy Subject
Status: COMPLETED
Conditions: Drug Use
Interventions: DRUG: Omeprazole 20 mg Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: CD40 Agonistic Antibody APX005M (Sotigalimab) in Combination With Nivolumab
Status: COMPLETED
Conditions: Cancer|Non Small Cell Lung Cancer Metastatic|Metastatic Melanoma|Neoplasm of Lung|Melanoma
Interventions: DRUG: APX005M|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy and Safety of Extended-Release Niacin + Laropiprant + Simvastatin in Participants With Primary Hypercholesterolemia or Mixed Dyslipidemia (MK-0524B-118)
Status: TERMINATED
Conditions: Primary Hypercholesterolemia|Dyslipidemia
Interventions: DRUG: Simvastatin|DRUG: Extended Release (ER) niacin/laropiprant/simvastatin (N/LRPT/SIM)|DRUG: Extended Release (ER) niacin/laropiprant (N/LRPT)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Sonic Fill and X-tra Fill in Clinical Performance
Status: COMPLETED
Conditions: SonicFill Clinical Performance|Sonicated Bulk-fill Resin Composite
Interventions: OTHER: bulk-fill composite resin restorations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Treatment With AMD3100 (Plerixafor) in MM Patients to Mobilize PBCs For Collection and for Transplantation
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: plerixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Wear Experience With a Water Surface Daily Disposable Contact Lens
Status: COMPLETED
Conditions: Contact Lens
Interventions: DEVICE: Comfilcon A Toric contact lenses|DEVICE: Verofilcon A for Astigmatism Daily Disposable contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia
Status: COMPLETED
Conditions: Patients With Febrile Neutropenia
Interventions: DRUG: Imipenem|DRUG: Imipenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Toripalimab in Combination With Platinum-based Chemotherapy for Mutation-negative Stage IV Oligometastatic NSCLC
Status: UNKNOWN
Conditions: NSCLC Stage IV|Oligometastasis
Interventions: DRUG: Toripalimab in Combination With Platinum-based Chemotherapy|PROCEDURE: Surgical treatment stage|DRUG: Adjuvant treatment stage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dipeptidyl Peptidase-4 Inhibitors and Alpha-cell Recovery
Status: COMPLETED
Conditions: Type 1 Diabetes|Hypoglycemia
Interventions: DRUG: Sitagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: The Effectiveness and Safety of FK-506 for the Treatment of Posner-Schlossman Syndrome
Status: UNKNOWN
Conditions: Posner Schlossman Syndrome
Interventions: DRUG: FK-506 (Drug)|DRUG: Prednisolone Acetate 1% Oph Susp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Pelvic Floor Exercise Training in Postmenopausal Genitourinary Syndrome
Status: COMPLETED
Conditions: Genitourinary Syndrome of Menopause
Interventions: OTHER: Pelvic floor exercise training|OTHER: Patient/individual education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RT Plus EGFR-TKI for Wild-type NSCLC
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer|Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR-TKI)
Interventions: DRUG: Erlotinib (trade name: Tarceva®) or Icotinib (trade name: Conmana®)|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Padeliporfin VTP Using Robotic Assisted Bronchoscopy in Peripheral Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Peripheral Lung Tumor
Interventions: COMBINATION_PRODUCT: Padeliporfin Vascular Targeted Photodynamic (VTP) therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microtransplantation to Treat Refractory or Relapsed Hematologic Malignancies in Younger Patients
Status: TERMINATED
Conditions: Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome (MDS)
Interventions: DRUG: Cytarabine|DRUG: Intrathecal Triples|BIOLOGICAL: HPC-A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prebiotic Treatment in People With Schizophrenia - Pilot Study
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Prebiotin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Validation of Laboratory Techniques, Strategies, and Types of Samples for Epidemiological Control in the Covid-19 Pandemic
Status: COMPLETED
Conditions: Covid19
Interventions: DIAGNOSTIC_TEST: RT-PCR|DIAGNOSTIC_TEST: LAMP|DIAGNOSTIC_TEST: POOL RT-PCR|DIAGNOSTIC_TEST: POOL LAMP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SCOPE-Study: Salzburg Chronic Obstructive Pulmonary Disease- Exercise and Oxygen Study
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Physical exercise training with supplemental oxygen|OTHER: Physical exercise training with "room air supplementation"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prostate Enucleation With Intravesical Botox Injections in Treating BPH and Bladder Overactivity
Status: NOT_YET_RECRUITING
Conditions: BPH|Intravesical Botox|Bipolar Enucleation of the Prostate|Overactive Bladder|Bladder Outlet Obstruction
Interventions: PROCEDURE: Bipolar enucleation of the prostate (BipolEP)|DRUG: Intravesical Botox injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Conversion Therapy of Chemotherapy Plus Camrelizumab in Metastatic Gastric Cancer
Status: COMPLETED
Conditions: Stomach Neoplasms
Interventions: DRUG: Camrelizumab|DRUG: S-1|DRUG: Oxaliplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tagraxofusp and Low-Intensity Chemotherapy for the Treatment of CD123 Positive Relapsed or Refractory Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Adult Lymphoblastic Lymphoma|Recurrent B Acute Lymphoblastic Leukemia|Recurrent T Acute Lymphoblastic Leukemia|Refractory B Acute Lymphoblastic Leukemia|Refractory Lymphoblastic Lymphoma|Refractory T Acute Lymphoblastic Leukemia
Interventions: DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Dexamethasone|BIOLOGICAL: Filgrastim-sndz|DRUG: Leucovorin|DRUG: Mercaptopurine|DRUG: Mesna|DRUG: Methotrexate|BIOLOGICAL: Pegfilgrastim|DRUG: Prednisone|BIOLOGICAL: Rituximab|BIOLOGICAL: Tagraxofusp-erzs|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multiple Ascending Dose Study in Healthy Volunteers and Patients With Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer's Disease
Interventions: DRUG: BMS-984923|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of Diathermy Versus Blunt Dissection in TEP for Inguinal Hernia
Status: COMPLETED
Conditions: Seroma|Hernia, Inguinal
Interventions: PROCEDURE: Monopolar energy|PROCEDURE: Blunt dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of an Interdisciplinary Pain Education Program in Public Health: a Pragmatic Clinical Trial
Status: UNKNOWN
Conditions: Musculoskeletal Pain
Interventions: BEHAVIORAL: Interdisciplinary Pain Education Program|OTHER: Conventional Physiotherapy treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: This Study is to Compare and Evaluate the Safety and Pharmacokinetic Characteristics (PK) After Administration of DW6014 and Each Component in Healthy Adult Volunteers in Fed Condition.
Status: NOT_YET_RECRUITING
Conditions: DW6014
Interventions: DRUG: DW6014
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilates-based Core Strengthening on Patellofemoral Pain Syndrome
Status: COMPLETED
Conditions: Patellofemoral Pain Syndrome
Interventions: OTHER: Pilates exercises|OTHER: Traditional physical therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of CC-220 in Subjects With Active Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Lupus Erythematosus, Systemic
Interventions: DRUG: CC-220|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: New Bioactive Restorative Material vs GIC in Restoration of Proximal Lesions
Status: UNKNOWN
Conditions: Randomized Clinical Trial
Interventions: PROCEDURE: New Bioactive Restorative Material (ACTIVA Presto)|OTHER: High Viscosity Glass Hybrid Reinforced Glass Ionomer (EQUIA Forte)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NSAID Injection Versus Corticosteroid Injection for Basilar Thumb Arthritis
Status: RECRUITING
Conditions: Thumb Osteoarthritis
Interventions: DRUG: Ketorolac|DRUG: Triamcinolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation of Cancer Survivors in Denmark: The Effect of a Psychosocial Rehabilitation Course
Status: COMPLETED
Conditions: Neoplasms|Breast Neoplasms|Colorectal Neoplasms|Prostatic Neoplasms
Interventions: BEHAVIORAL: Psychosocial rehabilitation course
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetics Of Sildenafil Orally Disintegrating Tablet Formulation Versus To Viagra® Oral Tablet.
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Sildenafil Tablet|DRUG: Sildenafil ODT|DRUG: Sildenafil ODT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of the Long GnRH Agonist Protocol and the Flexible GnRH Antagonist Protocol of Ovarian Stimulation
Status: UNKNOWN
Conditions: Infertility
Interventions: DRUG: Arvekap 0.1 mg (Triptorelin, Ipsen, France)|DRUG: Ganirelix 0.25 (Orgalutran, Organon, The Netherlands)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Fostamatinib to Treat Post-Hematopoietic Stem Cell Transplant Immune-mediated Cytopenias
Status: RECRUITING
Conditions: Immune Mediated Anemia|Immune Mediated Thrombocytopenia|Chronic GVHD
Interventions: DRUG: fostamatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abraxane and Temodar Plus Genasense in Advanced Melanoma
Status: UNKNOWN
Conditions: Melanoma
Interventions: DRUG: Genasense® (oblimersen)|DRUG: Abraxane® (paclitaxel protein-bound particles for injectable suspension)|DRUG: Temodar® (temozolomide)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tongue Pressure Profile Training for Dysphagia Post Stroke
Status: COMPLETED
Conditions: Dysphagia
Interventions: BEHAVIORAL: Tongue Pressure Profile Training|BEHAVIORAL: Tongue-Pressure Strength-and-Accuracy Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Physical Therapy Treatments of Myofascial Trigger Points in Subjects With Neck Pain
Status: UNKNOWN
Conditions: Neck Pain|Myofascial Pain Syndrome
Interventions: OTHER: Kinesiotherapy|OTHER: Ultrasound|OTHER: Diadynamic currents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IL2 Imaging in Metastatic Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DEVICE: IL2-PET scan|PROCEDURE: Tumor biopsy|DEVICE: CT scan|PROCEDURE: Biopsy of non-target tissue
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Indigotindisulfonate Sodium Injection, USP as an Aid in the Determination of Ureteral Patency in Patient's With Renal Impairment
Status: RECRUITING
Conditions: Ureter Injury
Interventions: OTHER: Saline Injection 0.9%|DRUG: Indigotindisulfonate sodium 0.8%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Zinc Absorption From Fortified Water
Status: COMPLETED
Conditions: Fractional Absorption of Zinc (Focus of the Study)
Interventions: DEVICE: LSF water without meal|DEVICE: LSF water and inhibitory meal|OTHER: Fortified inhibitory meal with water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sexual Dimorphism of Sphenoid and Maxillary Air Sinuses Via 3D Volumetric Segmentation of CBCT
Status: NOT_YET_RECRUITING
Conditions: Sexual Dimorphism|Cone-beam Computed Tomography|Maxillary Sinus|Sphenoid Sinus
Interventions: RADIATION: cone beam computer tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ad-HGF Treatment for Myocardial Infarction
Status: UNKNOWN
Conditions: Myocardial Infarction
Interventions: DRUG: Ad-HGF|OTHER: 0.9% NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Corneal Collagen Crosslinking to Increase the Resistance of the Support Graft of the KPro Type I Against Corneal Melting
Status: RECRUITING
Conditions: Corneal Melting in Boston Keratoprosthesis Type I
Interventions: PROCEDURE: Crosslinking with riboflavin of the corneal graft-support|PROCEDURE: De-epithelisation of the corneal graft support with instillation of riboflavin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MK0457 in Patients With Leukemia (0457-003)
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia in Blast Crisis|Lymphocytic Leukemia, B Cell, Acute|Myelodysplastic Syndromes|Myelogenous Leukemia, Chronic
Interventions: DRUG: MK0457
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Interruption of Natalizumab
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: natalizumab|DRUG: interferon beta 1-a|DRUG: methylprednisolone|OTHER: IV placebo|DRUG: glatiramer acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Adding Low Dose Ketamine or Fentanyl to Propofol-dexmedetomidine as Total Intravenous Anesthesia
Status: RECRUITING
Conditions: Patients Undergoing Elective Craniotomy
Interventions: DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: CLinical Efficacy of Hemoperfusion With a Cytokine Adsorber in Norepinephrine-Resistant SEptic Shock
Status: UNKNOWN
Conditions: Septic Shock|Cytokine Storm
Interventions: DEVICE: HA-330 Disposable Hemoperfusion Cartridge (Jafron, China)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Tolerability and Pharmacokinetics of ALD403
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: BIOLOGICAL: ALD403|BIOLOGICAL: ALD403|BIOLOGICAL: Sumatriptan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Venlafaxine to Reduce Cocaine Dependence in Depressed Individuals
Status: COMPLETED
Conditions: Cocaine-Related Disorders
Interventions: DRUG: Venlafaxine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Controlled Pilot Study to Assess Soft Tissue Reaction at the Crestal Part of a Dental Implant With ESTA Surface
Status: TERMINATED
Conditions: Teeth Loss
Interventions: DEVICE: Standard Plus ESTA STL Roxolid implant|DEVICE: Standard Plus STL implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Anti-CDH17 CAR-T Cell Injection in Patients With CDH17-positive Advanced Malignant Solid Tumors
Status: RECRUITING
Conditions: CDH17-positive Advanced Malignant Solid Tumors
Interventions: BIOLOGICAL: Anti-CDH17 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ATX-101 in Advanced Dedifferentiated Liposarcoma and Leiomyosarcoma
Status: TERMINATED
Conditions: Leiomyosarcoma|Liposarcoma
Interventions: DRUG: ATX-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Zanubrutinib, Obinutuzumab, and Venetoclax in Patients With Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL)
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia (CLL)|Small Lymphocytic Leukemia (SLL)
Interventions: DRUG: Zanubrutinib|DRUG: Obinutuzumab|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Famotidine and Antacids for Treatment of Dyspepsia
Status: RECRUITING
Conditions: Dyspepsia|GERD|Acid Reflux
Interventions: DRUG: Intravenous Famotidine|DRUG: Oral Maalox/ Mylanta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vinorelbine + Cisplatin or No Further Therapy in Non-small Cell Lung Cancer That Has Been Surgically Removed
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: vinorelbine ditartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D Supplementation in Patients With Heart Failure and Vitamin D Deficiency
Status: UNKNOWN
Conditions: Heart Failure|Vitamin D Deficiency
Interventions: OTHER: Vitamin D Supplementation|OTHER: Control group (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study With Parenteral Oxycodone, Morphine and Dexamethasone in Postoperative Pain in Paediatric Patients
Status: UNKNOWN
Conditions: Post Tonsillectomy Pain
Interventions: DRUG: 0,1 mg/kg of oxycodone|DRUG: Morphine 0,1 mg/kg|DRUG: Dexamethasone 0,5 mg/kg|DRUG: NaCl 0,9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dynamic Neuromuscular Stabilization Exercises in Patients With Lower Extremity Lymphedema
Status: NOT_YET_RECRUITING
Conditions: Lymphedema, Lower Limb
Interventions: OTHER: Dynamic Neuromuscular Stabilization Exercises|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Molecular Phenotype Changes and Personalized Treatment for CRPC
Status: UNKNOWN
Conditions: Hormone Refractory Prostate Cancer
Interventions: DRUG: Docetaxel & Prednisone|DRUG: DP & Targeted drugs|DRUG: cisplatin & Etoposide|DRUG: EP & Targeted drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Chimeric Receptor T Cells With Trastuzumab in HER2+ Advanced Breast Cancer and Other Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: HER2+ Advanced Breast Cancer|Other Solid Tumors
Interventions: DRUG: Chimeric receptor T-cells + Trastuzumab|DRUG: Fludarabine and Cyclophosphosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Cost-effectiveness, Efficacy, Safety and Tolerance of Mepilex® Ag Versus Silvadene®
Status: COMPLETED
Conditions: Second Degree Burn
Interventions: DEVICE: Mepilex|DEVICE: Silvadene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Real-time Pressure Volume Loop Monitoring as a Guide for Enhanced Understanding of Changes in Elemental Cardiovascular Physiology During Therapeutic Strategies Aiming for Hemodynamic Optimization. Cohort II: Structural Heart Interventions (PLUTO-II)
Status: RECRUITING
Conditions: Heart Failure|Valvular Heart Disease|Aortic Stenosis|Mitral Insufficiency|Tricuspid Insufficiency
Interventions: OTHER: Pressure volume (PV) loop measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Transfer Factor to Prevent Upper Respiratory Tract Infections in Healthy Adults
Status: COMPLETED
Conditions: Upper Respiratory Tract Infections Due to Influenza or Rhinovirus
Interventions: DIETARY_SUPPLEMENT: transfer factor|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Gene Therapy Trial to Evaluate the Safety and Efficacy of RP-L201 in Subjects With Leukocyte Adhesion Deficiency-I
Status: WITHDRAWN
Conditions: Leukocyte Adhesion Defect - Type I
Interventions: BIOLOGICAL: RP-L201
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Desmopressin Melt Therapy in Patients With Nocturnal Polyuria: a Pharmacokinetic/Dynamic Study
Status: COMPLETED
Conditions: Nocturnal Polyuria
Interventions: DRUG: Desmopressin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment With Acetyl-Choline Esterase Inhibitors in Children With Autism Spectrum Disorders
Status: UNKNOWN
Conditions: Autism
Interventions: DRUG: Acetyl-Choline Esterase Inhibitors and Choline supplements|DRUG: Indistinguishable placebo tablets, matching both donepezil and choline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tenofovir Disoproxil Fumarate in Combination of Hepatitis B Vaccine for Preventing Hepatitis B Vertical Transmission
Status: UNKNOWN
Conditions: Hepatitis B Infection|Congenital Malformation|Birth Defect|Viremia|Chronic Infection
Interventions: DRUG: Tenofovir Disoproxil Fumarate (TDF) 300 mg oral daily.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Investigate the Absorption, Metabolism and Excretion of [14C] ASP2215 in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors|Pharmacokinetics of 14C-labeled Gilteritinib
Interventions: DRUG: gilteritinib|DRUG: 14C-labeled gilteritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Product Feasibility of a New Silicone Hydrogel Contact Lens
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Bausch & Lomb Test lens|DEVICE: Ciba Vision soft contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING