pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Feasibility Study of the Intravascular Ventricular Assist System (iVAS)
Status: UNKNOWN
Conditions: Heart Failure NYHA Class III|Heart Failure NYHA Class IV
Interventions: DEVICE: intravascular ventricular assist system (iVAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of CNTX-4975 in Subjects With Chronic, Moderate to Severe Osteoarthritis Knee Pain
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: CNTX-4975|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Application of Shock Wave Technique After Rotator Cuff Operation
Status: RECRUITING
Conditions: Rotator Cuff Tear
Interventions: PROCEDURE: Divergent low energy shock wave|PROCEDURE: Divergent low energy shock wave|PROCEDURE: Divergent medium and low energy shock wave|PROCEDURE: Divergent medium and low energy shock wave|PROCEDURE: Focused low energy shock wave|PROCEDURE: Divergent medium energy shock wave|PROCEDURE: Divergent medium energy shock wave|PROCEDURE: Non-exposed group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the PrePex Device for Rapid Scale-up of VMMC, Phase 3 Field Implementation Trial With HIV + Adult Males
Status: COMPLETED
Conditions: HIV Seropositivity
Interventions: DEVICE: PrePex male circumcision device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of a Cranberry Beverage on Intestinal Permeability and Gastrointestinal Function in Generally Healthy Adults
Status: COMPLETED
Conditions: Intestinal Permeability|Gastrointestinal Function
Interventions: OTHER: Cranberry Beverage|OTHER: Control Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prostate Cancer Stereotactic Radiotherapy
Status: COMPLETED
Conditions: Prostate Neoplasms|Toxicity Due to Radiotherapy
Interventions: RADIATION: Fractionation|RADIATION: hypofractionated|RADIATION: stereotactic fractionation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studies of COVID-19 Patients Treated With Oral Bismuth Subsalicylate (Pepto-Bismol)
Status: COMPLETED
Conditions: Diarrhea|COVID-19
Interventions: DRUG: Bismuth Subsalicylate 262 milligram (mg) Oral Tablet, Chewable|OTHER: Placebo oral tablet without BSS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism
Status: UNKNOWN
Conditions: Sleep Bruxism
Interventions: DRUG: Botulinum toxin type A (Meditoxin®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation in Decompensated Cirrhosis
Status: COMPLETED
Conditions: Liver Cirrhosis
Interventions: OTHER: Fecal Microbiota Transplantation|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Implementation Strategies to Scale-up Transdiagnostic Evidence-based Mental Health Care in Zambia
Status: COMPLETED
Conditions: Depression|Post-traumatic Stress Disorder|Anxiety|Substance Abuse
Interventions: BEHAVIORAL: In-person CETA|BEHAVIORAL: Telephone CETA|BEHAVIORAL: Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lithium for the Treatment of Pediatric Mania
Status: COMPLETED
Conditions: Bipolar I Disorder Without Psychotic Symptoms
Interventions: DRUG: Lithium Carbonate|DRUG: Lithium Carbonate|DRUG: Lithium Carbonate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Jaktinib Hydrochloride Tablets in the Treatment of Severe Novel Coronavirus Pneumonia
Status: NOT_YET_RECRUITING
Conditions: Novel COVID-19-Infected Pneumonia
Interventions: DRUG: Jaktinib hydrochloride tablets|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effects of Itraconazole on the Pharmacokinetics of JNJ-42165279 in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-42165279|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of Film-coated Tablet and Dry Syrup 1% Form for E2020 in Healthy Japanese Adult Males
Status: COMPLETED
Conditions: Healthy Adult
Interventions: DRUG: Donepezil Hydrochloride|DRUG: Donepezil Hydrochloride|DRUG: Donepezil Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Trial of Paclitaxel, Bevacizumab, and Enzastaurin Versus Paclitaxel, Bevacizumab and Placebo for Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Enzastaurin|DRUG: Bevacizumab|DRUG: Paclitaxel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinicopathological MRI and CSF Correlates in Huntington's Disease.
Status: UNKNOWN
Conditions: Huntington Disease
Interventions: DIAGNOSTIC_TEST: 7T MRI-scan|DIAGNOSTIC_TEST: CSF collection via lumbar puncture|DIAGNOSTIC_TEST: Blood withdrawal|DIAGNOSTIC_TEST: Clinical measures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of Impact of Inspiratory Muscle Training on Movement Fear Due to Dyspnea in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: COPD
Interventions: OTHER: Inspiratory muscle trainig
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vitamin D and Arterial Function in Patients With Chronic Kidney Disease
Status: COMPLETED
Conditions: Arterial Dysfunction|Chronic Kidney Disease
Interventions: DRUG: Cholecalciferol|DRUG: Calcitriol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of NVC-422 on Bacteriuria in Catheterized Patients
Status: COMPLETED
Conditions: Asymptomatic Bacteriuria
Interventions: DRUG: sodium 2-(dichloroamino)-2-methylpropane-1-sulfonate monohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeting Beta-cell Failure in Lean Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Liraglutide|DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of a New Technology for Isolating Circulating Tumour Cells
Status: UNKNOWN
Conditions: HER2-positive Metastatic Breast Cancer|Ovarian Cancer|Hormone-resistant Prostate Cancer|Circulating Tumor Cell
Interventions: PROCEDURE: Blood sample collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dexmedetomidine for Laryngeal Mask Airway Insertion
Status: COMPLETED
Conditions: Drug Usage
Interventions: DRUG: dexmedetomidine|DRUG: propofol|DEVICE: laryngeal mask airway (LMA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RCT to Analyze the Efficacy of a Spanish Healthcare ministRy Based In InTervention to Reduce Frailty Status in Prefrail Older Adults
Status: RECRUITING
Conditions: Frailty|Aged|Exercise
Interventions: OTHER: Multicomponent physical exercise program and a nutritional intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Core Biopsy vs Fine Needle Aspiration for Evaluation of Axillary Lymphadenopathy
Status: COMPLETED
Conditions: Focus: Breast Cancer With Axillary Node Metastasis
Interventions: PROCEDURE: Fine needle aspiration and core biopsy of lymph node|PROCEDURE: Axillary surgery|OTHER: Titanium marker
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comprehensive Prognostic Model: The Study Introduces a Novel Prognostic Model That Incorporates a Wide Range of Clinical and Laboratory Variables, Providing a More Holistic Approach to Predicting Overall Survival in HCC Patients
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: OTHER: Randomization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Interaction Study to Evaluate the Effect of Esomeprazole/Acetylsalicylic Acid on the Metabolism and Effect of Clopidogrel
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Clopidogrel|DRUG: Esomeprazole/ASA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Repetitive Transcranial Magnetic Stimulation in the Treatment of Cognitive Impairment in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Spinal Cord Stimulation for the Treatment of Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: Active transcutaneous spinal direct current stimulation|DEVICE: Sham transcutaneous spinal direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Orally Administered Enasidenib (AG-221) in Adults With Advanced Solid Tumors, Including Glioma, or Angioimmunoblastic T-cell Lymphoma, With an IDH2 Mutation
Status: COMPLETED
Conditions: Solid Tumor|Glioma|Angioimmunoblastic T-cell Lymphoma|Intrahepatic Cholangiocarcinoma|Chondrosarcoma
Interventions: DRUG: Enasidenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Arthritis With Syk Kinase Inhibition (TASKI-1)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: R788|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Proof-of-concept RCT of Version 3.0 of the Smoking Cessation Smartphone App "Smiling Instead of Smoking" (SiS)
Status: COMPLETED
Conditions: Nondaily Smoking
Interventions: BEHAVIORAL: Smartphone app "Smiling instead of Smoking" (SiS) Version 3|BEHAVIORAL: Smartphone app "QuitGuide" (QG)|BEHAVIORAL: Brochure "Clearing the Air" (CTA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of Subretinal Transplantation of Clinical Human Embryonic Stem Cell Derived Retinal Pigment Epitheliums in Treatment of Retinitis Pigmentosa
Status: UNKNOWN
Conditions: Retinitis Pigmentosa
Interventions: BIOLOGICAL: Retinal pigment epitheliums transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Virtual Reality Asymmetric Training of Technology And Tactics for Professional Basketball Players
Status: ENROLLING_BY_INVITATION
Conditions: Asymmetric Limb Muscle Stiffness|Recovery, Psychological|Body Schema
Interventions: BEHAVIORAL: Virtual reality basketball asymmetric training|BEHAVIORAL: Traditional basketball asymmetric training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Non-interventional, Retrospective Cohort Study to Explore Antidepressant Treatment in Korea
Status: COMPLETED
Conditions: Major Depression
Interventions: DRUG: Escitalopram|DRUG: Paroxetine|DRUG: Fluoxetine|DRUG: Mirtazapine|DRUG: Duloxetine|DRUG: Sertraline|DRUG: Venlafaxine|DRUG: Tianeptine|DRUG: Vortioxetine|DRUG: Desvenlafaxine|DRUG: Bupropion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomized Controlled Trial of Aspirin vs Placebo in the Treatment of Pre-psychosis
Status: TERMINATED
Conditions: Clinical High Risk for Psychosis
Interventions: DRUG: Aspirin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Distress Associated With Coronavirus Disease 2019 and Telehealth on Supportive Care Patients With Advanced Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|COVID-19 Infection|Hematopoietic and Lymphoid Cell Neoplasm|Locally Advanced Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm|Recurrent Hematologic Malignancy|Recurrent Malignant Solid Neoplasm
Interventions: OTHER: Survey Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impairment of Central Coherence in Restrictive Anorexia Nervosa (CoCA)
Status: COMPLETED
Conditions: Anorexia Nervosa
Interventions: BEHAVIORAL: One interview of 90 minutes with a part of cognitive assessment and a part of self-assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Older Adults
Status: COMPLETED
Conditions: Older Adults (50-90 Years)
Interventions: DEVICE: brain stimulation|DEVICE: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Supraphysiological Doses of Levothyroxine as Adjunctive Therapy in Bipolar Depression
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: L-Thyroxine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Dose-finding Study of TS-172 in Hyperphosphatemia Patients on Hemodialysis
Status: COMPLETED
Conditions: Hyperphosphatemia Patients on Hemodialysis
Interventions: DRUG: TS-172 10mg bid|DRUG: TS-172 30mg bid|DRUG: TS-172 60mg bid|DRUG: TS-172 20mg tid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Performance Evaluation of the LumiraDx SARS-CoV-2 & FLU A/B and SARS-CoV-2 & RSV Tests for Aid in the Assessment of COVID-19
Status: COMPLETED
Conditions: COVID-19|Influenza A|Influenza Type B|RSV Infection
Interventions: DIAGNOSTIC_TEST: LumiraDx SARS-CoV-2 & Flu A/B test|DIAGNOSTIC_TEST: LumiraDx SARS-CoV-2 & RSV test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pulmonary Embolism as a Cause of COPD Exacerbations
Status: COMPLETED
Conditions: Pulmonary Embolism|Chronic Obstructive Pulmonary Disease
Interventions: PROCEDURE: Diagnostic and therapeutic strategy: Highly sensitive D-dimer testing and, if positive, multidetector computed tomographic pulmonary angiography (MDCT).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use Of Hall Technique In Deciduous Molars Affected By Extensive Caries Lesions
Status: NOT_YET_RECRUITING
Conditions: Caries
Interventions: PROCEDURE: Restoration with Resin|PROCEDURE: Hall Technique|PROCEDURE: Conventional Steel Crown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Monitoring of the Bone Free Flaps With Microdialysis
Status: RECRUITING
Conditions: Flap Necrosis
Interventions: BIOLOGICAL: glucose measurement|BIOLOGICAL: lactacte measurement|BIOLOGICAL: pyruvate measurement|BIOLOGICAL: glycerol measurement|PROCEDURE: Bone free flap monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Injectable Poly-L-Lactic Acid for Volume Loss in the Temples Using Dual Plane Injections
Status: NOT_YET_RECRUITING
Conditions: Lipoatrophy|Aging
Interventions: DEVICE: Sculptra aesthetic
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Electronic Health Record-Based Interventions for Improving Follow-Up in Primary Care
Status: COMPLETED
Conditions: Colon Cancer|Lung Cancer|Prostate Cancer
Interventions: BEHAVIORAL: Contact Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Acceptance and Commitment Training for Adolescents and Young Adults With Neurofibromatosis Type 1, Plexiform Neurofibromas, and Chronic Pain
Status: COMPLETED
Conditions: Neurofibromatosis Type 1|Plexiform Neurofibromas
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy (ACT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acceptance Commitment Therapy for Caregivers of People With Memory Loss
Status: ACTIVE_NOT_RECRUITING
Conditions: Caregiver Burden|Behavioral and Psychiatric Symptoms of Dementia|Depressive Symptoms|Quality of Life|Psychological Flexibility|Sleep Quality|Positive Aspects of Caregiving
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Reduction in Sedation: Colonoscopy vs Esophagoduodenoscopy First
Status: UNKNOWN
Conditions: Anesthesia, Recovery
Interventions: OTHER: Colonoscopy followed by EGD|OTHER: EGD followed by Colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Artesunate+Sulfadoxine-Pyrimethamine for the Treatment of Uncomplicated Falciparum Malaria
Status: COMPLETED
Conditions: Falciparum Malaria
Interventions: DRUG: artesunate plus sulfadoxine-pyrimethamine (AS+SP)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nivolumab and Temozolomide Versus Temozolomide Alone in Newly Diagnosed Elderly Patients With GBM
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Nivolumab|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mind Body Therapy for the Treatment of Chronic Pain
Status: COMPLETED
Conditions: Chronic Pain|Chronic Pain Syndrome
Interventions: BEHAVIORAL: Mind Body Intervention 1: Mind-Body-Syndrome-Therapy (MBST)|BEHAVIORAL: Mind Body Intervention 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery
Status: UNKNOWN
Conditions: Degenerative Disc Disease|Spondylolisthesis
Interventions: DEVICE: Prefix (AMPLEX) B2A Peptide Enhanced Ceramic Granules|OTHER: Iliac crest autograft|DEVICE: Prefix (AMPLEX) B2A Peptide Enhanced Ceramic Granules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Performance and Safety of the PHENIX LIBERTY, a Medical Device for Electrostimulation and Biofeedback, in the Treatment of Musculoskeletal Disorders
Status: RECRUITING
Conditions: Musculoskeletal Disorder
Interventions: DEVICE: Electrical stimulation and biofeedback with Phenix Liberty medical device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Saw Palmetto and Sanmiaoshan on Benign Prostatic Hyperplasia in Chinese Patients
Status: UNKNOWN
Conditions: Prostatic Hyperplasia|Adrenergic Alpha-Antagonists
Interventions: DRUG: Saw palmetto and sanmiaoshan capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of the Combination of Irinotecan and POF (POFI) and Tislelizumab
Status: RECRUITING
Conditions: Gastric Cancer Stage IV
Interventions: DRUG: Oxaliplatin|DRUG: Levo-Leucovorin|DRUG: 5-fluorouracil|DRUG: Paclitaxel|DRUG: Irinotecan|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Preliminary Efficacy Study of MRG001 in Patients With Non-Hodgkin Lymphoma (NHL)
Status: UNKNOWN
Conditions: Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (NHL)
Interventions: DRUG: MRG001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Planning Operative Strategy Using a Digital Renal Artery Clamping Tool
Status: RECRUITING
Conditions: Kidney Cancer|Kidney Neoplasms|Kidney Diseases|Renal Cancer|Renal Cell Carcinoma|Renal Disease
Interventions: DEVICE: Pre-operative explanation of the procedure (DIPLANN + CT)|DEVICE: Pre-operative surgical planning (DIPLANN + CT)|PROCEDURE: RAPN (DIPLANN + CT)|DEVICE: Pre-operative explanation of the procedure (CT only)|DEVICE: Pre-operative surgical planning (CT only)|PROCEDURE: RAPN (CT only)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Intralipid Versus Olive Oil Infusions on Endothelial Function, Immune Function, Inflammatory Markers
Status: WITHDRAWN
Conditions: Diabetes|Hypertension|Obesity
Interventions: DRUG: Twenty-four Hour TPN and Saline Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Exercise and Cognitive Training on Community-dwelling Older Adults With Dementia.
Status: COMPLETED
Conditions: Dementia|Exercise|Fall|Cognitive Training
Interventions: BEHAVIORAL: A 12-week weekly sports and cognitive training intervention.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Party Balloon Assisted Valsalva in Diagnosis of Superficial Venous Valvular Reflux of Lower Limb
Status: COMPLETED
Conditions: Varicose Veins|Venous Insufficiency
Interventions: PROCEDURE: Valsava
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Aktiv i Sør: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Physical Activity
Interventions: BEHAVIORAL: Intervention group - telephone and print exercise intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of Gemcitabine Plus Bevacizumab in Patients With Platinum-Resistant Ovarian, Primary Peritoneal or Fallopian Tube Cancer
Status: WITHDRAWN
Conditions: Fallopian Tube Neoplasms|Ovarian Cancer|Primary Peritoneal
Interventions: DRUG: Gemcitabine/Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Pacing Rate for Cardiac Resynchronization Therapy
Status: RECRUITING
Conditions: Atrial Fibrillation, Persistent
Interventions: DEVICE: Pacing rate of 80 bpm|DEVICE: Pacing rate of 60 bpm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reminding Patients of the Important of Colorectal Cancer Screening Results in Patient-Initiated Promoting Colorectal Cancer Screening Via Colonoscopy
Status: COMPLETED
Conditions: Colon Cancer
Interventions: OTHER: Colorectal cancer screening pamphlet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: Changes in Cardiac Autonomic Nervous System Following Atrial Fibrillation Ablation.
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Radio-frequency ablation|PROCEDURE: Cryoballoon ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cladribine Plus Pegylated Interpheron Alfa-2a in Systemic Mastocytosis
Status: UNKNOWN
Conditions: Systemic Mastocytosis
Interventions: DRUG: Cladribine and pegylated interpheron alpha-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy With or Without Wobe-Mugos E in Treating Patients With Stage II or Stage III Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: Wobe-Mugos E|DRUG: melphalan|DRUG: prednisone|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Exploring the Effect of Lactate Administration After Ischemic Stroke on Brain Metabolism
Status: UNKNOWN
Conditions: Stroke, Acute
Interventions: DRUG: Lactate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on the Safety and Tolerability of Rovalpituzumab Tesirine in Japanese Patients With Advanced, Recurrent Small Cell Lung Cancer
Status: COMPLETED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Rovalpituzumab tesirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy and Safety Evaluation of Teneligliptin in Type 2 Diabetes Who Have Inadequate GlycemIc Control With Empaglyflozin and Metformin
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: Teneligliptin (as Teneligliptin Hydrobromide) 20 Mg Oral Tablet|DRUG: Teneligliptin Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Incidence of Residual Neuromuscular Blockade in Intra-abdominal Surgery: A Prospective, Observational Study
Status: COMPLETED
Conditions: Neuromuscular Blockade|Pulmonary Complication
Interventions: DEVICE: Stimpod NMS450® Nerve Stimulator, by Xavant™ Technology
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: AZD8683 Multiple Dose Study in Healthy Volunteers and Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: TERMINATED
Conditions: COPD
Interventions: DRUG: AZD8683|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Neuroprotective Effect of Lamotrigine and Interferon Beta 1a in Patients With Relapsing-Remitting Multiple Sclerosis
Status: UNKNOWN
Conditions: Relapsing-Remitting Multiple Sclerosis
Interventions: DRUG: lamotrigine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Lactulose for Bowel Preparation in Patients With Inflammatory Bowel Disease
Status: COMPLETED
Conditions: IBD
Interventions: DRUG: 3 bottles of Lactulose oral solution|DRUG: 3L-polyethylene glycol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retinal Effects of Balance Goggles System in Glaucoma Balance Goggles System (BGS) in Patients With Glaucoma
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DEVICE: BGS goggles
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Keloidscars With Intralesional Triamcinolone and 5-fluorouracil Injections-prospective, Randomized, Controlled Trial - Pilot Study
Status: COMPLETED
Conditions: Keloidscars
Interventions: DRUG: 5-fluorouracil|DRUG: Triamcinolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FOCUS: PCC + Bevacizumab + CA4P Versus PCC + Bevacizumab + Placebo for Subjects With Platinum Resistant Ovarian Cancer
Status: TERMINATED
Conditions: Platinum Resistant Ovarian Cancer
Interventions: DRUG: Fosbretabulin tromethamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Versus Intermittent Bolus Feeding in Very Preterm Infants - Effect on Respiratory Morbidity
Status: UNKNOWN
Conditions: Chronic Lung Disease of Prematurity|Bronchopulmonary Dysplasia
Interventions: OTHER: Method of feeding; continuous feeding OR bolus feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Thoracic Surgery Combined With Intrathoracic Hyperthermic Perfusion for Advanced Lung Cancer / Esophageal Cancer
Status: WITHDRAWN
Conditions: Esophageal Cancer|Lung Cancer|Hyperthermic Perfusion
Interventions: OTHER: hyperthermic perfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation in Glomerular Disease
Status: COMPLETED
Conditions: Glomerular Disease
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol, 2000 or 4000 IUs by mouth daily for 12 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-incision Versus Conventional Laparoscopic Surgery for Colorectal Cancer
Status: WITHDRAWN
Conditions: Colorectal Cancer|Colonic Neoplasms|Rectal Neoplasms|Colon Disease|Colon Cancer|Rectal Cancer|Rectal Diseases
Interventions: PROCEDURE: Single-incision Laparoscopic Surgery|PROCEDURE: Conventional Laparoscopic Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endobronchial Mucosal Biopsy in Patients With Suspected Pulmonary Sarcoidosis
Status: COMPLETED
Conditions: Endobronchial Mucosal Pathology in Pulmonary Sarcoidosis
Interventions: PROCEDURE: Bronchoscopic mucosal biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety Evaluation of Sintilimab in Patients With Advanced or Metastatic Non-squamous NSCLC
Status: COMPLETED
Conditions: Lung Neoplasms
Interventions: DRUG: Sintilimab|DRUG: Pemetrexed|DRUG: Platinum|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Subcostal TAP Block For Percutaneous Nephrolithotomy
Status: COMPLETED
Conditions: Nephrolithiasis
Interventions: PROCEDURE: Subcostal transversus abdominis plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of Basmisanil in Participants With Cognitive Impairment Associated With Schizophrenia (CIAS) Treated With Antipsychotics
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Basmisanil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Novel Augmentation of DAOIB and Antioxidant for Early Dementia
Status: RECRUITING
Conditions: Alzheimer Disease|Mild Cognitive Impairment
Interventions: DRUG: DAOIB plus AO|DRUG: DAOIB plus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Emotional Processing and Memory Evaluation in Epilepsy Patients
Status: COMPLETED
Conditions: Epilepsy
Interventions: BEHAVIORAL: TLE Arm 1|BEHAVIORAL: Emotion Memory Test|BEHAVIORAL: Emotion Memory Testing|BEHAVIORAL: Emotion Memory Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Huachansu & Gemcitabine in Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: HuaChanSu|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing the Efficacy of Progressive Muscle Relaxation Using Placebo Mechanisms in an Guided and Unguided Online-intervention
Status: COMPLETED
Conditions: Healthy Participants
Interventions: BEHAVIORAL: Video optimizing expectations before PMR (unguided) + Progressive Muscle Relaxation (PMR)|BEHAVIORAL: Video optimizing expectations before PMR (guided) + Progressive Muscle Relaxation (PMR)|BEHAVIORAL: Neutral video before PMR (unguided) + Progressive Muscle Relaxation (PMR)|BEHAVIORAL: Neutral video before PMR (guided)+ Progressive Muscle Relaxation (PMR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: TMC435-TiDP16-C114 - A Study in Healthy Volunteers Investigating the Pharmacokinetic Interaction Between TMC435 and the Antiretroviral Agents TMC278 and Tenofovir
Status: COMPLETED
Conditions: Hepatitis C Virus
Interventions: DRUG: TMC435|DRUG: TDF|DRUG: TMC435 + TDF|DRUG: TMC435 + TMC278|DRUG: TMC278|DRUG: TMC435
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Tinnitus With Migraine Medications
Status: RECRUITING
Conditions: Tinnitus, Subjective|Tinnitus
Interventions: DRUG: Nortriptyline + topiramate|DRUG: Verapamil + paroxetine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Long-term Safety Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Tirzepatide|DRUG: Oral antihyperglycemic medication (OAM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Normobaric Oxygen Therapy for Individuals With First-Episode Psychosis
Status: RECRUITING
Conditions: Psychosis|Schizophrenia|First-episode Psychosis
Interventions: DEVICE: Normobaric Oxygen|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Orthodontic Treatment on Periodontally Compromised Dentition- Randomised Control Trial
Status: UNKNOWN
Conditions: Periodontal Bone Loss
Interventions: PROCEDURE: Periodontal and orthodontic treatment|PROCEDURE: periodontal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Multicentric Study of Digoxin Per os in Classic or Endemic Kaposi' s Sarcoma
Status: UNKNOWN
Conditions: Kaposi' s Sarcoma|Classic Kaposi' s Sarcoma|Endemic Kaposi' s Sarcoma|Lymph Angio Proliferations
Interventions: DRUG: digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: R-CHOP14 or R-CHOP21 &Consolidation PET-Oriented Radiotherapy (RT) in DLBCL Patients
Status: COMPLETED
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: Treatment plan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability and Pharmacokinetics of MT-6345 in Healthy Subjects
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: MT-6345|DRUG: MT-6345 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study Investigating the Effectiveness of a LifeSeasons NeuroQ Supplement With Lifestyle Changes to Improve Cognitive Function in Healthy Adults Who Have One or More Risk Factors for Cognitive Decline
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: NeuroQ
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Endothelial Function in Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea of Adult
Interventions: DRUG: Atorvastatin 10mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Aortic Stenosis and PhosphodiEsterase Type 5 iNhibition (ASPEN): A Pilot Study
Status: TERMINATED
Conditions: Aortic Stenosis|LV Remodeling, Hypertrophy
Interventions: DRUG: Tadalafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Flow Nasal Oxygen Versus VNI in Acute Hypercapnic Cardiogenic Pulmonary Edema
Status: UNKNOWN
Conditions: Acute Cardiogenic Pulmonary Edema|Hypercapnic Respiratory Failure
Interventions: DEVICE: High flow nasal oxygen therapy|DEVICE: Non invasive ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Xylitol Gum Chewing on Postoperative Bowel Activity
Status: COMPLETED
Conditions: Xylitol Gum Chewing|Non-xylitol Gum Chewing|Control Group
Interventions: OTHER: xylitol chewing gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of NMD670 in Ambulatory Adult Patients With Type 3 Spinal Muscular Atrophy
Status: RECRUITING
Conditions: Spinal Muscular Atrophy
Interventions: DRUG: NMD670|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term Results of the Canadian Breast IMRT Study
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DEVICE: Adjuvant breast radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: I-Gel vs Ambu Laryngeal Mask Airways in Infants and Children Undergoing Surgical Procedures
Status: COMPLETED
Conditions: Laryngeal Masks
Interventions: DEVICE: Ambu LMA|DEVICE: I-Gel LMA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Efficacy and Safety of Ospemifene in the Treatment of Vulvar and Vaginal Atrophy (VVA) in Postmenopausal Women
Status: COMPLETED
Conditions: Atrophy|Vaginal Diseases
Interventions: DRUG: Placebo|DRUG: Ospemifene 5 mg|DRUG: Ospemifene 15 mg|DRUG: Ospemifene 30 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Snapshot Audit of Traumatic Pelvic Ring Injuries
Status: NOT_YET_RECRUITING
Conditions: Pelvic Trauma|Pelvic Fracture|Fragility Fractures of the Pelvis (FFP)
Interventions: OTHER: Snapshot-audit studies do not necessitate any intervention in the defined cohorts.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: EVM16 Injection as a Single and Combination With Tislelizumab in Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced or Recurrent Solid Tumors
Interventions: BIOLOGICAL: EVM16|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study In Postmenopausal Women With Type 2 Diabetes Looking At Approved Diabetes Drugs And How They Affect Bone Health
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Rosiglitazone|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Clinical Study of VC005 Tablets in Subjects With Active Ankylosing Spondylitis.
Status: COMPLETED
Conditions: Active Ankylosing Spondylitis
Interventions: DRUG: VC005 tablets|DRUG: Tofacitinib Citrate Tablets|DRUG: VC005 Tablets Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-level and Mixed-method Impact Evaluation for the Jockey Club Elders Get Active Fitness Campaign
Status: RECRUITING
Conditions: Aging Well
Interventions: BEHAVIORAL: Equipment box|BEHAVIORAL: Equipment box with briefing|BEHAVIORAL: Exercise training|BEHAVIORAL: Exercise training with behavioral modification
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of PR013 Topical Ophthalmic Drops Compared to Vehicle for the Treatment of Allergic Conjunctivitis
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: PR013 (0.045%)|DRUG: PR013 (0.06%)|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Therapy of Nivolumab and Adoptive T Cell Therapy in Metastatic Melanoma Patients
Status: UNKNOWN
Conditions: Melanoma
Interventions: DRUG: TIL + IL-2 + Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Lactobacillus Casei Shirota on the Small Intestinal Microbiota (ROBIN)
Status: UNKNOWN
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Lactobacillus casei strain Shirota (LcS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing a 6-month vs Long-term Course of Rezvilutamide With ADT Plus Chemotherapy in mHSPC
Status: RECRUITING
Conditions: Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
Interventions: DRUG: 6-month course of antiandrogen drugs|DRUG: Long-term course of antiandrogen drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intestinal Adsorbent and Breath Gas Levels
Status: COMPLETED
Conditions: Gastroesophageal Reflux|Small Intestinal Bacterial Overgrowth
Interventions: DEVICE: Intestinal adsorbent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Design of a Prototype Garment Adapted to Demented Elderly Subjects With Disturbing Behavioral Problems in the Management of Sphincter Disorders
Status: COMPLETED
Conditions: Adapted Garment Prototype|Elderly|Problem Behavior|Dementia|Sphincter Disorders
Interventions: OTHER: garment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE