pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of the Effect and Safety of Sparsentan in the Treatment of Patients With IgA Nephropathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Immunoglobulin A Nephropathy
Interventions: DRUG: sparsentan|DRUG: irbesartan|DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: REstoration of VItamin D in Pulmonary Arterial Hypertension
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Artery Hypertension|Vitamin d Deficiency
Interventions: DRUG: Calcifediol Oral Capsule|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study in Patients With Chronic Idiopathic Thrombocytopenic Purpura in R788
Status: COMPLETED
Conditions: Idiopathic Thrombocytopenic Purpura
Interventions: DRUG: R788|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ketogenic Diet - a Randomized, Controlled, Cross-over Study
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Ketogenic diet for four weeks, then a 15 week washout, and finally a NFA recommended diet for four weeks|OTHER: NFA recommended diet for four weeks, then a 15 week washout, and finally a ketogenic diet for four weeks.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Evaluate Adenosine Monophosphate and Allergen Challenge in Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: levocetirizine|DRUG: placebo to levocetirizine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remotely Delivered Behavioral Weight Loss Using an Ad Libitum Plant-Based Diet Versus a Balanced Calorie Deficit Diet
Status: COMPLETED
Conditions: Obesity|Overweight
Interventions: BEHAVIORAL: Lifestyle Modification Intervention|BEHAVIORAL: Balanced Calorie Deficit Eating Plan|BEHAVIORAL: Ad Libitum Whole Food Plant-Based Eating Plan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: mHealth for Smoking Cessation in Public Housing
Status: WITHDRAWN
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Smoking cessation + quitline linkage text messages|BEHAVIORAL: Passive quitline referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Xerostomia Pilot Fudan: Acupuncture for Prevention of Radiation-Induced Xerostomia
Status: UNKNOWN
Conditions: Head and Neck Cancer|Xerostomia
Interventions: OTHER: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: 2nd Study to Assess ISV-305 Compared to Vehicle for Treatment of Inflammation and Pain Associated With Cataract Surgery
Status: COMPLETED
Conditions: Inflammation and Pain Associated With Cataract Surgery
Interventions: DRUG: ISV-305|OTHER: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Branched-chain Amino Acid Supplementation and Exercise on Muscle Quantity and Quality in Cirrhosis
Status: COMPLETED
Conditions: Muscle Atrophy
Interventions: DIETARY_SUPPLEMENT: BCAA|OTHER: home-based graded exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modulation of Human Myocardial Metabolism by GLP-1 Dose Response
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Healthy
Interventions: DRUG: GLP-1 Low Dose|DRUG: GLP-1 Mid-Range Dose|DRUG: GLP-1 High Dose|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bronchodilators and Respiratory Mechanics in Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Salbutamol + Tiotropium|DRUG: Placebo + Tiotropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cluster Randomised Trial of Malaria RDTs Used by CHWs in Afghanistan
Status: COMPLETED
Conditions: Malaria|Fever|Acute Febrile Illness|Pneumonia
Interventions: DEVICE: Malaria Rapid Diagnostic test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of an Essential Oil and a Delmopinol Mouthrinse Effect on Dental Plaque Accumulation Index, Gingivitis Index and on Streptococcus Mutans, Lactobacillus, Aerobic and Anaerobic Oral Bacteria Colony Counts.
Status: COMPLETED
Conditions: Gingivitis|Dental Plaque Accumulation
Interventions: DRUG: Essential oils mouthrinse|DRUG: Delmopinol mouthrinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies
Status: COMPLETED
Conditions: Melanoma|Non-small Cell Lung Cancer|Breast Cancer|Gastric Cancer|Renal Cell Carcinoma|Ovarian Cancer|Cholangiocarcinoma|Bladder Urothelial Carcinoma|Pancreatic Adenocarcinoma|Colorectal Cancer|Esophageal Cancer|Hepatic Cancer|Head and Neck Cancer|Primary Peritoneal Cancer|Fallopian Tube Cancer|Other Solid Tumors|Diffuse Large B-cell Lymphoma (DLBCL)|Mantle Cell Lymphoma|Indolent B-cell Lymphomas|Non-Hodgkin Lymphoma|Follicular Lymphoma|Lymphoplasmacytic Lymphoma|Waldenstrom's Disease|Marginal Zone Lymphoma|Mucosa Associated Lymphoid Tissue|Small Lymphocytic Leukemia
Interventions: DRUG: CDX-1140|DRUG: CDX-301|DRUG: pembrolizumab|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Administration Routes of Dexmedetomidine on Postoperative Delirium
Status: RECRUITING
Conditions: Dexmedetomidine|Postoperative Delirium|General Anesthesia
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Preprocedural Subanesthetic Ketamine on Pain and Anxiety
Status: COMPLETED
Conditions: Epidural Catheterization|Thoracic|Procedural Pain
Interventions: DRUG: Ketamine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Angiotensin II Injection Versus Placebo in Patients With Refractory Distributed Shock
Status: NOT_YET_RECRUITING
Conditions: Vasodilatory Shock
Interventions: DRUG: Angiotensin II Injection|DRUG: 0.9% sodium chloride injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zonegran for the Treatment of Weight Gain Associated With Psychotropic Medication Use: A Placebo-Controlled Trial
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Zonegran|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Expanded Access Program for Epcoritamab
Status: APPROVED_FOR_MARKETING
Conditions: Large B-cell Lymphoma|Diffuse Large B-Cell Lymphoma, Not Otherwise Specified|Primary Mediastinal Large B-cell Lymphoma (PMBCL)|High Grade B-cell Lymphoma (HGBCL)|Grade 3B Follicular Lymphoma
Interventions: BIOLOGICAL: Epcoritamab
Study Type: EXPANDED_ACCESS
Clinical trial: Open Lung Strategy During Non-Invasive Respiratory Support of Very Preterm Infants in the Delivery Room
Status: COMPLETED
Conditions: Respiratory Distress Syndrome in Premature Infant|Non-invasive Ventilation|Lung Injury
Interventions: PROCEDURE: openCPAP|PROCEDURE: standardCPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Treatment of Toenail Onychomycosis With a 1064 nm Nd:YAG-laser
Status: COMPLETED
Conditions: Onychomycosis of Toenail
Interventions: DEVICE: 1064 nm Nd:YAG-laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-dose Furmonertinib Versus Osimertinib in Advanced EGFRm NSCLC Patients With Brain Metastases
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer, Nonsmall Cell
Interventions: DRUG: Furmonertinib|DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effects of a Dyad Intervention on Teacher Resilience, Mental Health, and Social Emotions and Behavior
Status: NOT_YET_RECRUITING
Conditions: Burnout
Interventions: BEHAVIORAL: Empathy-based socio-emotional mental training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate Safety and Efficacy Following Dosing of Oxycodone/Naltrexone for Treatment of Adults With Pain Following Bunionectomy Surgery
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Oxycodone Naltrexone (a)|DRUG: Oxycodone Naltrexone (b)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adult ALL Treatment at Diagnosis
Status: COMPLETED
Conditions: Leukemia, Lymphocytic, Acute
Interventions: DRUG: Vincristine|DRUG: Vincristin, Daunorubicine, Asparaginase, Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Immunogenicity of a Polyvalent Pneumococcal Conjugate Vaccine (V116) in Japanese Adults (V116-002)
Status: COMPLETED
Conditions: Pneumococcal Infection
Interventions: BIOLOGICAL: V116|BIOLOGICAL: PNEUMOVAX™23
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Eplivanserin 5mg/Day in Insomnia Characterized by Sleep Maintenance Difficulties
Status: COMPLETED
Conditions: Primary Insomnia
Interventions: DRUG: Eplivanserin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Erzhi Tiangui Formula in Expected POR Women Undergoing IVF-ET
Status: ENROLLING_BY_INVITATION
Conditions: Infertility, Female
Interventions: DRUG: Erzhi Tiangui Granule|DRUG: Erzhi Tiangui Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CNS10-NPC-GDNF for the Treatment of ALS
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: BIOLOGICAL: Stem cell (HPC) implantation|DEVICE: Stereotactic surgical device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Different Hypopressive Exercises in Pelvic Floor Dysfunction
Status: COMPLETED
Conditions: Pelvic Floor Disorders
Interventions: OTHER: Hypopressive exercises|OTHER: Hypopressive maneuver|OTHER: Hypopressive exercises plus pelvic floor muscle contraction|OTHER: Hypopressive maneuver plus pelvic floor muscle contraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Fistulous Crohn's Disease by Implant of Autologous Mesenchymal Stem Cells Derived From Adipose Tissue
Status: COMPLETED
Conditions: Crohn Disease
Interventions: OTHER: Autologous mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Global Warming Impact of Nitrous Oxide
Status: COMPLETED
Conditions: Global Warming Effect of Nitrous Oxide
Interventions: DRUG: Nitrous oxide|DRUG: Nitrous oxide|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase II Study of Folotyn With Leucovorin to Prevent/Reduce Mucositis in Patients With Hematological Malignancies
Status: COMPLETED
Conditions: Relapsed Peripheral T-Cell Lymphoma|Refractory Peripheral T-Cell Lymphoma
Interventions: DRUG: Folotyn and Leucovorin|DRUG: Folic Acid|DRUG: Vitamin B12
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Atezolizumab After Chemo-radiotherapy for MIBC Patients Not Eligible for Radical Cystectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Bladder Cancer
Interventions: DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plastic Stents Compared With Metal Stents in Treating Patients With Malignant Dysphagia Caused by Esophageal Cancer or Gastroesophageal Junction Cancer
Status: WITHDRAWN
Conditions: Esophageal Cancer|Gastrointestinal Complications
Interventions: PROCEDURE: management of therapy complications|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Angiotensin Converting Enzyme Inhibitors During Cardiopulmonary Bypass in Infants and Children
Status: COMPLETED
Conditions: Congenital Heart Disease
Interventions: DRUG: Angiotensin Converting Enzyme Inhibitor|OTHER: No ACE Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Telemonitoring on Functionality, Quality of Life and Risk of Lymphedema in Breast Cancer Survivors
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: OTHER: Kinesiotherapy protocol|OTHER: Usual orientations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ropivacaine Hypobaric Spinal Anaesthesia in Traumatic Hip Surgery
Status: COMPLETED
Conditions: Femoral Neck Fracture
Interventions: DRUG: 6 mg of ropivacaine|DRUG: 8 mg of ropivacaine|DRUG: 10 mg of ropivacaine|DRUG: 12 mg of ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of JNJ-63623872 at Steady-state on the Steady-state Pharmacokinetics of Ethinylestradiol and Norethindrone
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ethinylestradiol|DRUG: Norethindrone|DRUG: JNJ-63623872
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Performance Evaluation of Clinical Ultrasound in Management of Acute Pulmonary Edema in Elderly Patient
Status: COMPLETED
Conditions: Pulmonary Edema|Respiratory Distress Syndrome
Interventions: DEVICE: Strategy with lung ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pilot Study: Treatment of Achilles Tendinopathy With Platelet-Rich Plasma Therapy
Status: COMPLETED
Conditions: Achilles Tendinitis
Interventions: OTHER: Autologous Platelet Rich Plasma|OTHER: Ultrasound Imaging|OTHER: Quality of Life Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human Papillomavirus (HPV) Registration Study (Gardasil)(V501-023)(COMPLETED)
Status: COMPLETED
Conditions: Papillomavirus Infections
Interventions: BIOLOGICAL: Gardasil™|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Antibiotic Therapy in Preventing Early Infection in Patients With Multiple Myeloma Who Are Receiving Chemotherapy
Status: COMPLETED
Conditions: Infection|Multiple Myeloma
Interventions: DRUG: ciprofloxacin|DRUG: ofloxacin|DRUG: 160 mg trimethoprim and 800 mg sulfamethoxazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PET/CT Scan as a Tool to Rationalize the Treatment of Patients With Advanced ColoRectal Cancer Undergoing First-line Medical Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer Stage IV
Interventions: PROCEDURE: PET/CT|DRUG: first-line chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects on the Scalp Microbiota of a 1% Selenium Disulfide and 1% Salicylic Acid Shampoo After 2% Ketaconazole Foaming Gel Treatment for Scalp Seborrheic Dermatitis
Status: COMPLETED
Conditions: Scalp Dermatitis|Dermatitis
Interventions: OTHER: cosmetic product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Rifampin on the Metabolism of Istradefylline in Healthy Volunteers.
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Istradefylline 40 mg|DRUG: Rifampin 300mg BID + istradefylline 40mg Day 8 only
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study With LY293111, Gemcitabine and Placebo in Patients With Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: LY293111|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Entecavir in Blacks/African Americans and Hispanics With Chronic Hepatitis B Virus (HBV) Infection
Status: COMPLETED
Conditions: Hepatitis B Infection
Interventions: DRUG: Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rimonabant In Prediabetic Subjects To Delay Onset Of Type 2 Diabetes
Status: TERMINATED
Conditions: Prediabetic State
Interventions: DRUG: Rimonabant|DRUG: Placebo (for Rimonabant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ventilatory Strategies After Cardiopulmonary Bypass Evaluated by Electrical Impedance Tomography
Status: COMPLETED
Conditions: Elective Cardiac Surgical Patients
Interventions: OTHER: ventilation mode setting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pilot Study to Assess Efficacy and Safety of a Triple Therapy With Asunaprevir, Daclatasvir, and BMS-791325 in HCV Genotype 4-infected Patients After Failure of Pegylated Interferon-Ribavirin Regimen
Status: WITHDRAWN
Conditions: Hepatitis C Virus Genotype 4 Infection
Interventions: DRUG: .Asunaprevir, Daclatasvir and BMS - 791325
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Multimodal Training of Combined Cognitive and/or Physical Training on Cognition and Fitness of Older Adults
Status: UNKNOWN
Conditions: Cognitive Decline|Cognitive Impairment, Mild
Interventions: BEHAVIORAL: Cognitive training|BEHAVIORAL: physical training|BEHAVIORAL: Combination of cognitive and physical training (CCPT)-BIGMAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Improving the Quality of Cardiopulmonary Resuscitation (CPR) During Pediatric Cardiac Arrest
Status: COMPLETED
Conditions: Cardiac Arrest
Interventions: DEVICE: CPRcard|OTHER: Just in Time Video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Doxil and Gemcitabine in Recurrent Ovarian Cancer
Status: TERMINATED
Conditions: Ovarian Carcinoma
Interventions: DRUG: liposomal doxorubicin and gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the AFB and Stenting of the Iliac Arteries
Status: UNKNOWN
Conditions: Aorta-iliac Segment Lesion (C,D Type by TASC II)
Interventions: PROCEDURE: Aorta-femoral bypass|PROCEDURE: Recanalization and stenting of aorta-iliac segment|DRUG: Therapy: aspirin and clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fibrin Sealant Spray Versus Mechanical Stapling in Laparoscopic Totally Extraperitoneal Hernioplasty
Status: COMPLETED
Conditions: Hernia
Interventions: DEVICE: Fibrin sealant spray|DEVICE: Mechanical stapling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Therapeutic for Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD)
Status: COMPLETED
Conditions: Major Depressive Disorder|Generalized Anxiety Disorder
Interventions: DEVICE: HPDT-DA-013
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Drug Loaded Microsphere Bronchial Artery Chemoembolization (DEB-BACE) Combined With Anlotinib and Adebelimumab in the Third Line Treatment of Advanced NSCLC: a Prospective, Single Arm, Single Center, Exploratory Clinical Study
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Early Hemodynamic Management of Patients Following Acute Spinal Cord Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Cord Injury
Interventions: OTHER: Augmented Blood Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Large Macular Hole Closure Rate With Amniotic Membrane Graft With and Without Limitorrhexis
Status: UNKNOWN
Conditions: Macular Holes
Interventions: PROCEDURE: Macular hole closure with amniotic membrane with/without internal limiting membrane peeling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Safety and Efficacy of Dexmedetomidine (DEX) in Intubated and Mechanically Ventilated Pediatric Intensive Care Unit (PICU) Subjects
Status: COMPLETED
Conditions: Sedation
Interventions: DRUG: Dexmedetomidine|DRUG: Midazolam|DRUG: Fentanyl|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Rindopepimut After Conventional Radiation in Children w/ Diffuse Intrinsic Pontine Gliomas
Status: TERMINATED
Conditions: Brain Cancer|Brain Stem Tumors|Pontine Tumors
Interventions: BIOLOGICAL: Rindopepimut
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of CeraVe® Moisturizing Cream on Skin Pruritus in Elderly Patients
Status: RECRUITING
Conditions: Pruritus
Interventions: OTHER: CeraVe® Moisturising Cream|OTHER: Standard Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human Milk Fortification With Adjustable Versus Targeted Method
Status: RECRUITING
Conditions: Growth Failure
Interventions: DIETARY_SUPPLEMENT: Adjustable Human Milk Fortification|DIETARY_SUPPLEMENT: Targeted Human Milk Fortification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prevalence of Pelvic Floor Dysfunctions in Female Badminton Athletes and Sedentary
Status: NOT_YET_RECRUITING
Conditions: Pelvic Floor Disorders
Interventions: OTHER: Assessment of pelvic floor dysfunctions' symptoms and sings, pelvic floor muscle strength and quality of life
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Platelet Rich Plasma and Autologous Fat Graft for Diabetic Ulcer
Status: COMPLETED
Conditions: Diabetes Mellitus Foot Ulcer
Interventions: PROCEDURE: Fat grafting|PROCEDURE: Fat grafting + platelet rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Donors With Nephrolithiasis at the Time of Transplant Evaluation (DONATE). Long Term Follow-up.
Status: COMPLETED
Conditions: Kidney Stones
Interventions: DIAGNOSTIC_TEST: low dose radiation abdomen/pelvis CT scan (stone protocol)|PROCEDURE: Blood draw|OTHER: 24 hour urine collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Learning Curve, Outcome Parameters, and MRI Assessment of Disc Evacuation After Transforaminal Percutaneous Endoscopic Lumbar Discectomy
Status: COMPLETED
Conditions: Herniated Nucleus Pulposus
Interventions: PROCEDURE: Transforaminal Percutaneous Endoscopic Lumbar Decompression
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Drug Eluting and Bare Metal Stents With or Without Abciximab in ST Elevation Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Abciximab|DEVICE: bare metal stent prokinetic, chrono, skylor or bluemedical|DEVICE: drug eluting stent (sirolimus eluting) - CYPHER stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of NM8074 in Soliris-Treated Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)
Status: NOT_YET_RECRUITING
Conditions: PNH - Paroxysmal Nocturnal Hemoglobinuria
Interventions: DRUG: NM8074
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Immunogenicity Study of Heterologous and Homologous Prime-Boost Ebola Vaccine Regimens in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: MVA-BN-Filo|BIOLOGICAL: Ad26. ZEBOV|BIOLOGICAL: MVA-BN-Filo|BIOLOGICAL: Ad26. ZEBOV|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective, Non-Randomized, Evaluation of Low-Risk Patients Undergoing Carotid Stenting With ANgiomax (Bivalirudin)
Status: UNKNOWN
Conditions: Carotid Stenosis
Interventions: DEVICE: Carotid PTA and stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-Dose Trial to Examine the Within Subject Variability of Clexane® in Healthy Adults Under Fasting Conditions
Status: COMPLETED
Conditions: Clexane is Administered to Healthy Volunteers
Interventions: BIOLOGICAL: Enoxaparin sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparing Mortality for Low vs High Peripheral Oxygen Saturation in COPD-patients With Acute Exacerbation
Status: RECRUITING
Conditions: COPD Exacerbation|Chronic Obstructive Pulmonary Disease Exacerbation
Interventions: DRUG: Oxygen gas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Objective of This Study is to Evaluate the Efficacy and Safety of Botulax® in Patients With Essential Blepharospasm.
Status: COMPLETED
Conditions: Essential Blepharospasm
Interventions: DRUG: Botulinum toxin type A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2b Study of GCS-100 in Patients With Chronic Kidney Disease Caused by Diabetes
Status: UNKNOWN
Conditions: Diabetic Chronic Kidney Disease
Interventions: DRUG: GCS-100|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of BOTOX Injections to Assess Change in Disease Symptoms in Adult Participants With Upper Limb Essential Tremor
Status: ACTIVE_NOT_RECRUITING
Conditions: Upper Limb Essential Tremor (UL ET)
Interventions: BIOLOGICAL: BOTOX|DRUG: Placebo for BOTOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pramipexole Dihydrochloride 0.25 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pramipexole Dihydrochloride|DRUG: Pramipexole Dihydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Selumetinib and Cetuximab in Treating Patients With Refractory Solid Tumors
Status: COMPLETED
Conditions: Recurrent Colon Cancer|Recurrent Rectal Cancer|Stage IVA Colon Cancer|Stage IVA Rectal Cancer|Stage IVB Colon Cancer|Stage IVB Rectal Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: selumetinib|BIOLOGICAL: cetuximab|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Belzutifan|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Brain-Penetrating HIV Drugs to Prevent Cognitive Impairment in China
Status: COMPLETED
Conditions: HIV Infections|Central Nervous System Diseases|Dementia
Interventions: DRUG: zidovudine-lamivudine-nevirapine|DRUG: tenofovir-lamivudine-efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of the SL PLUS and the SL PLUS MIA Hip Stem
Status: COMPLETED
Conditions: Coxarthrosis
Interventions: PROCEDURE: primary total hip arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Oral Treatment With BIBF 1120 ES in Advanced Non-small-cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: BIBF 1120 ES low dose|DRUG: BIBF 1120 ES high dose|DRUG: Placebo to BIBF 1120 ES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: ICare Self-tonometry - A Head-to-head Comparison to the Gold Standard Goldmann Tonometer
Status: UNKNOWN
Conditions: Glaucoma
Interventions: DEVICE: Home iCare (study nurse)|DEVICE: goldmann applanation tonometry|DEVICE: home iCare (by patient)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sacral Nerve Stimulation for Mild-to-Moderate or Refractory Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DEVICE: Sacral nerve stimulation|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neural Adaptations to a Single Session of Metronome-Paced Strength Training
Status: ENROLLING_BY_INVITATION
Conditions: Healthy
Interventions: OTHER: Fractal Paced|OTHER: Isochronus Paced|OTHER: Self Paced
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase II Study of First-line SBRT in Patients With Non-Metastatic Unresectable Pancreatic Cancer
Status: WITHDRAWN
Conditions: Pancreatic Tumor
Interventions: RADIATION: Stereotactic Body Radiation Therapy (SBRT)|RADIATION: Tissue, Blood, Research Imaging (TBRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-transplant Immunosuppression and Donor Stem Cell Transplant for the Treatment of Severe Hemoglobinopathies
Status: WITHDRAWN
Conditions: Beta Thalassemia Major|Sickle Beta 0 Thalassemia|Sickle Beta Plus Thalassemia|Sickle Beta Thalassemia|Sickle Cell Disease|Sickle Cell-SS Disease
Interventions: DRUG: Bortezomib|DRUG: Busulfan|DRUG: Cyclophosphamide|DRUG: Dexamethasone|DRUG: Fludarabine Phosphate|PROCEDURE: Hematopoietic Cell Transplantation|BIOLOGICAL: Lapine T-Lymphocyte Immune Globulin|DRUG: Mycophenolate Mofetil|PROCEDURE: Plasmapheresis|BIOLOGICAL: Rituximab|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Multi-disciplinary Approach of Children With Feeding Difficulties and Tube Feeding in UZB Between 2000 and 2021
Status: ENROLLING_BY_INVITATION
Conditions: Oral Aversion|Enteral Nutrition|Parenteral Nutrition|Tube Feeding
Interventions: COMBINATION_PRODUCT: Structured multi-disciplinary approach
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)
Status: RECRUITING
Conditions: Colorectal Cancer|Resectable Colorectal Carcinoma
Interventions: DRUG: Trastuzumab deruxtecan|DRUG: Durvalumab|DRUG: Panitumumab|DRUG: Botensilimab|DRUG: Balstilimab|DRUG: Sotorasib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a Zoster Vaccine in SLE
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: Zostavax|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Feasibility of Providing Cognitive Remediation to People With Schizophrenia in a Clinical Network
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Targeted cognitive training|BEHAVIORAL: Computer control|BEHAVIORAL: Bridging groups|BEHAVIORAL: Health and wellness groups
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Babies in Glasses; a Feasibility Study.
Status: UNKNOWN
Conditions: Cerebral Visual Impairment|Refractive and Accommodative Disorders|Hypoxic-Ischemic Encephalopathy|Premature Birth
Interventions: DEVICE: Near vision spectacles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Obstetric Anesthesia and Delivery Mode On Neurodevelopmental And Behavioural Outcomes In A Population-Based Birth Cohort
Status: COMPLETED
Conditions: Neurodevelopmental Disorders|Behavior
Interventions: OTHER: Behavioural questionnaires and assessments on mother and child
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Potential Role of Inflammasome NLRP3 And IL-1B Gene Expression in COVID-19 Patients: Impact of Ferretin and D -Dimer.
Status: RECRUITING
Conditions: Inflammasome NLRP3 And IL-1B Gene Expression in COVID-19 Patients
Interventions: GENETIC: Quantitative Real Time Polymerase chain reaction (qRT-PCR)|DIAGNOSTIC_TEST: ELISA and colorimeter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TOF-18F-FDG-PET/CT in Patients With Suspected Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer|Pancreatitis|IPMN
Interventions: DIAGNOSTIC_TEST: PET/CT results with TOF/without TOF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Total pancrEaTectomy vs High-Risk Pancreatic anastomosiS
Status: RECRUITING
Conditions: Pancreatic Fistula
Interventions: PROCEDURE: Total pancreatectomy|PROCEDURE: Pancreatic anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics & Safety of Diclofenac Potassium Oral Solution in Ped. Subjects (2-12 Yrs) With Mild-Mod. Acute Pain
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: diclofenac potassium oral solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of M3814 (Peposertib) to Radiation Therapy for Patients With Advanced Head and Neck Cancer Who Cannot Take Cisplatin
Status: RECRUITING
Conditions: Advanced Head and Neck Squamous Cell Carcinoma|Advanced Hypopharyngeal Squamous Cell Carcinoma|Advanced Laryngeal Squamous Cell Carcinoma|Advanced Oral Cavity Squamous Cell Carcinoma|Advanced Oropharyngeal Squamous Cell Carcinoma|Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Stage III Hypopharyngeal Carcinoma AJCC v8|Stage III Laryngeal Cancer AJCC v8|Stage III Lip and Oral Cavity Cancer AJCC v8|Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IVA Hypopharyngeal Carcinoma AJCC v8|Stage IVA Laryngeal Cancer AJCC v8|Stage IVA Lip and Oral Cavity Cancer AJCC v8|Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IVB Hypopharyngeal Carcinoma AJCC v8|Stage IVB Laryngeal Cancer AJCC v8|Stage IVB Lip and Oral Cavity Cancer AJCC v8|Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Interventions: PROCEDURE: Computed Tomography|OTHER: Fludeoxyglucose F-18|RADIATION: Intensity-Modulated Radiation Therapy|PROCEDURE: Magnetic Resonance Imaging|DRUG: Peposertib|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Niraparib Combination Therapies for the Treatment of Metastatic Castration-Resistant Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostatic Neoplasms, Castration-Resistant
Interventions: DRUG: Niraparib 200 mg|DRUG: Cetrelimab 240 mg|DRUG: Cetrelimab 480 mg|DRUG: Abiraterone acetate 1000 mg|DRUG: Prednisone 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy After Surgery in Treating Patients With High-Risk Stage II or Stage III Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: capecitabine|DRUG: fluorouracil|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of GnRH-A [Leuprorelin(Lorelin Depot] Plus Leterozole +/- Everolimus for Premenopausal Women With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Everolimus(afinitor)|DRUG: Letrozole|DRUG: Leuprolide(Lorelin Depot)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Harmonic in Laparoscopic Cholecystectomy for Acute Cholecystitis
Status: COMPLETED
Conditions: Cholecystitis
Interventions: PROCEDURE: early LC within 72 hours after the diagnosis with H (Harmonic)|PROCEDURE: early LC within 72 hours after the diagnosis with MD (Monopolar Diathermy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Hsp90 Inhibitor AUY922 for the Treatment of Patients With Refractory Gastrointestinal Stromal Tumor
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumor
Interventions: DRUG: AUY922
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 4-Aminopyridine in Episodic Ataxia Type 2
Status: WITHDRAWN
Conditions: Episodic Ataxia Type 2
Interventions: DRUG: 4-Aminopyridine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RCT Comparing EVLA Versus Polidocanol Foam in the Treatment of SSV Insufficiency
Status: COMPLETED
Conditions: Varicose Veins of Lower Limb
Interventions: DRUG: Ultrasound-guided-foam sclerotherapy (UGFS) using Polidocanol sclerosant|DEVICE: Endovenous Laser Ablation (EVLA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Surgery Versus 3 Days Non-surgical Management in Acute Small Bowel Obstruction (SURGI-BOW)
Status: RECRUITING
Conditions: Small Bowel Obstruction
Interventions: PROCEDURE: Standard support|PROCEDURE: Early surgery proposed according to the radiological score
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimal Electrophysiology and Imaging Enhanced Deep Brain Stimulation
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: PROCEDURE: Deep Brain Stimulation - Minimal Electrophysiology|PROCEDURE: Deep Brain Stimulation - Standard
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed Disodium and Gemcitabine in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: gemcitabine HCL|DRUG: pemetrexed disodium|DRUG: gemcitabine HCL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Glucocorticosteroid Treatment in the Patients With Chronic Recurrent DILI
Status: COMPLETED
Conditions: Drug-induced Liver Injury,Chronic
Interventions: DRUG: Methylprednisolone|DRUG: Standard Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of RET Inhibitor TAS0953/HM06 in Patients With Advanced Solid Tumors With RET Gene Abnormalities
Status: RECRUITING
Conditions: RET-altered Non Small Cell Lung Cancer|RET-altered Solid Tumors
Interventions: DRUG: TAS0953/HM06|DRUG: TAS0953/HM06
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Seasonal Influenza Vaccine by Jet Injection
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DEVICE: LectraJet|DEVICE: TIV by jet injection|BIOLOGICAL: Seasonal Trivalent Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Epidemiology of Pituitary Tumours: Prevalence of Associated Neoplasia
Status: UNKNOWN
Conditions: Pituitary Tumor|Endocrine Neoplasia|Hyperparathyroidism|Solid Tumor|Familial Tumor Syndrome
Interventions: OTHER: Registration of familial forms and associated neoplasia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mesoglycan, Vascular Reactivity and Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: PROCEDURE: Flow Mediated Dilation|DRUG: Mesoglycan|DRUG: Mesoglycan|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Treatment of Coronary Atherosclerosis by Insulin Sensitizers in Insulin-Resistant Patients
Status: UNKNOWN
Conditions: Coronary Atherosclerosis|Inflammation|Coronary Heart Disease
Interventions: DRUG: pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT