pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety of ETX-018810 for the Treatment of Diabetic Peripheral Neuropathic Pain
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathic Pain|Diabetic Peripheral Neuropathy
Interventions: DRUG: ETX-018810|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Near-death Experience in ICU Survivors
Status: COMPLETED
Conditions: Critical Illness|Near-Death Experience
Interventions: DIAGNOSTIC_TEST: Greyson NDE scale|DIAGNOSTIC_TEST: DES dissociation scale|DIAGNOSTIC_TEST: WHOQOL-SRPB|DIAGNOSTIC_TEST: cerebral magnetic resonance imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Efficacy After Allergen Challenge, Safety and Tolerability of Inhaled CHF6001 DPI in Asthmatics
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: CHF6001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Whether Probiotics Use in Neonate and Infant Improve Their Mother's Life Quality
Status: NOT_YET_RECRUITING
Conditions: Postpartum Depression|Quality of Life|Functional Gastrointestinal Disorders|Probiotics
Interventions: DIETARY_SUPPLEMENT: Probiotics group|DIETARY_SUPPLEMENT: Non-probiotics group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: CAR-T Cell Immunotherapy for GD2 Positive Glioma Patients
Status: WITHDRAWN
Conditions: GD2 Positive Glioma|CAR-T Cell Immunotherapy
Interventions: BIOLOGICAL: CAR-T cell immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stretching With And Without Pressure Biofeeback In Patients With Postural Syndrome
Status: COMPLETED
Conditions: Postural; Defect
Interventions: OTHER: biofeedback|OTHER: hamstrings stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acceptability and Feasibility of Home-based TB Testing
Status: COMPLETED
Conditions: Tuberculosis, Pulmonary|Households
Interventions: DIAGNOSTIC_TEST: Home-based point-of-care (POC) TB testing using GeneXpert device + MTB/RIF test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Assessing the Impact of Brief CBTi on Dissociative Seizures: SCED
Status: RECRUITING
Conditions: Dissociative Seizures|Functional Seizures|Psychogenic Nonepileptic Seizures|Insomnia|Dissociation|Sleep Disorder
Interventions: BEHAVIORAL: brief Cognitive Behavioural Therapy for Insomnia (bCBTi)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brightline-3: A Study to Find Out Whether Brigimadlin in Combination With Ezabenlimab Helps People With Advanced Soft Tissue Sarcoma
Status: WITHDRAWN
Conditions: Advanced Soft Tissue Sarcoma|Undifferentiated Pleomorphic Sarcoma (UPS)|Myxofibrosarcoma (MFS)
Interventions: DRUG: Brigimadlin|DRUG: Ezabenlimab|DRUG: Gemcitabine|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics (PK) of Ertapenem Intravenous (IV) Bolus Versus Standard Infusion
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ertapenem|DRUG: ertapenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?
Status: RECRUITING
Conditions: OSA|Sleep Apnea|Obstructive Sleep Apnea|Alzheimer Disease
Interventions: OTHER: Supplemental Oxygen|DEVICE: Continuous Positive Airway Pressure Machine|OTHER: Room Air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: BlueWind RENOVA iStim™ System for the Treatment of OAB
Status: RECRUITING
Conditions: Treatment of Patients Suffering From Overactive Bladder (OAB)
Interventions: DEVICE: RENOVA iStim™ System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rod Shape Changing After Scoliosis Correction Surgery
Status: COMPLETED
Conditions: Scoliosis Idiopathic|Scoliosis, Severe
Interventions: DIAGNOSTIC_TEST: 3D Scanning|DIAGNOSTIC_TEST: EOS 2D/3D scanning
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iodine I 131 Tositumomab and Fludarabine Phosphate in Treating Older Patients Who Are Undergoing an Autologous or Syngeneic Stem Cell Transplant for Relapsed or Refractory Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Splenic Marginal Zone Lymphoma|Waldenström Macroglobulinemia
Interventions: DRUG: fludarabine phosphate|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: iodine I 131 tositumomab|OTHER: laboratory biomarker analysis|OTHER: flow cytometry|GENETIC: polymerase chain reaction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantitative 18F-AV-133 PET Imaging in Subjects With Diabetes and Healthy Controls
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: 18F-AV-133|DRUG: 10% Arginine Hydrochloride-R-Gene 10
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Exploring the Efficacy and Usability of the My Autism Passport (MAP).
Status: UNKNOWN
Conditions: Autism Spectrum Disorder
Interventions: DEVICE: My Autism Passport (MAP) Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Tolerability of BL-1020 in Hospitalized Subjects With Chronic Schizophrenia or Schizo-Affective Disorder
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: BL-1020|DRUG: BL 1020 High Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effect of Melatonin and Vitamin C Administration, Alone or In Combination in Major Abdominal Surgery.
Status: NOT_YET_RECRUITING
Conditions: Postoperative Pain
Interventions: DRUG: Melatonin 10 MG|DRUG: Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Efficacy of Intramuscular Islet Autograft After Extensive Pancreatectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Disorder of Endocrine Pancreas
Interventions: DRUG: Intramuscular Islet Autograft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Node-sparing Short-Course Radiation Combined With CAPOX and Tislelizumab for MSS Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer
Interventions: RADIATION: node-sparing modified short-course radiotherapy|DRUG: PD-1 antibody|DRUG: Capecitabine|DRUG: Oxaliplatin|RADIATION: standard short-course radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: May Preoperative Waist to Height Ratio Predict Postoperative Weight Loss in Bariatric Patients?
Status: UNKNOWN
Conditions: Bariatric Surgery Candidate|Obesity, Morbid
Interventions: PROCEDURE: laparoscopic sleeve gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Freeze-dried Live Attenuated Influenza Vaccine for Intranasal Administration in Chinese Adults Aged 3 Years and Older
Status: UNKNOWN
Conditions: Influenza
Interventions: BIOLOGICAL: one dose of Influenza Vaccine|BIOLOGICAL: one dose of Influenza Vaccine|BIOLOGICAL: placebo|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Ear Comfort Ear Drops to Treat AOE Cases Compared to DexOtic & Otidin(R)
Status: UNKNOWN
Conditions: Acute Otitis Externa
Interventions: DEVICE: Natural Ear Comfort(TM), a botanical ear drops product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of SHR0302 in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: SHR0302|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of CO2 vs Room Air Insufflation During ESD for Gastric Tumor
Status: COMPLETED
Conditions: Gastric Tumor
Interventions: PROCEDURE: CO2 or room air insufflation during ESD for gastric tumor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Statins for Pulmonary and Cardiac Complications of Chronic HIV - Coordinating Center
Status: COMPLETED
Conditions: HIV Seropositivity
Interventions: DRUG: Placebo|DRUG: Rouvastatin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: huJCAR014 CAR-T Cells in Treating Adult Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma or Acute Lymphoblastic Leukemia
Status: TERMINATED
Conditions: Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent B-Cell Non-Hodgkin Lymphoma|Recurrent Diffuse Large B-Cell Lymphoma|Recurrent Primary Mediastinal (Thymic) Large B-Cell Lymphoma|Refractory Adult Acute Lymphoblastic Leukemia|Refractory B-Cell Non-Hodgkin Lymphoma|Refractory Diffuse Large B-Cell Lymphoma|Refractory Primary Mediastinal (Thymic) Large B-Cell Lymphoma|Recurrent Transformed Non-Hodgkin Lymphoma|Recurrent High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements|Refractory High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements|Recurrent B Acute Lymphoblastic Leukemia|Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified|Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements|Refractory B Acute Lymphoblastic Leukemia|Refractory Diffuse Large B-Cell Lymphoma, Not Otherwise Specified|Refractory High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements
Interventions: BIOLOGICAL: Autologous Human Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes|DRUG: Cyclophosphamide|DRUG: Fludarabine|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Leukapheresis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Targeted And Response-Guided Albumin Therapy Versus Standard Medical Treatment In Outcomes Of Recurrent Ascites In Patients With Decompensated Cirrhosis.
Status: UNKNOWN
Conditions: Decompensated Cirrhosis
Interventions: BIOLOGICAL: Albumin|DRUG: Standard Medical Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Acarbose on Intestinal Microbiome and Incretins of Type 2 Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: Glipizide|DRUG: Acarbose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Biomarker-driven Targeted Therapy in Patients With Recurrent Platinum-resistant Epithelial Ovarian Cancer
Status: NOT_YET_RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: Pamiparib|DRUG: Bevacizumab|DRUG: Tislelizumab|DRUG: Nab paclitaxel|DRUG: Bevacizumab + Nab paclitaxel (intense dose-dense)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality vs Traditional Cognitive Training in Patients With Severe Acquired Brain Injury
Status: NOT_YET_RECRUITING
Conditions: Acquired Brain Injury
Interventions: DEVICE: Khymeia®-Virtual Reality rehabilitation System (VRRS EVO SYSTEM or COMPACT VRRS ENGINE)|BEHAVIORAL: Traditional cognitive training (TCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Harmonizing Optimal Strategy for Treatment of Coronary Artery Diseases Trial - Comparison of REDUCTION of PrasugrEl Dose & POLYmer TECHnology in ACS Patients (HOST REDUCE POLYTECH RCT Trial)
Status: UNKNOWN
Conditions: Acute Coronary Syndrome
Interventions: DEVICE: BS-DES (Biostable polymer drug-eluting stent)|DEVICE: BD-DES (Biodegradable polymer drug-eluting stent)|DRUG: Prasugrel 5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Complex Regional Pain Syndrome With Once Daily Gastric-Retentive Gabapentin (Gralise)
Status: TERMINATED
Conditions: Complex Regional Pain Syndrome I (CRPS I)
Interventions: DRUG: Gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Axicabtagene Ciloleucel Given With Steroids In Participants With Relapsed Or Refractory Large B-Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed or Refractory Large B-cell Lymphoma
Interventions: BIOLOGICAL: Axicabtagene Ciloleucel|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gait Analysis Following Knee Viscosupplementation
Status: COMPLETED
Conditions: Gait|Knee Osteoarthritis|Injection
Interventions: DRUG: hyaluronic acid with mannitol|DRUG: hyaluronic acid with sorbitol|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Efficacy and Safety of Oral Immunotherapy With GcMAF in Hospitalized Patients With COVID-19 Pneumonia
Status: COMPLETED
Conditions: COVID-19 Pneumonia
Interventions: DIETARY_SUPPLEMENT: Saisei Maf capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Combination of Ixazomib and Lenalidomide and Dexamethasone in Smoldering Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Smoldering Multiple Myeloma
Interventions: DRUG: Ixazomib|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Tacrolimus in Liver Transplantation Patients Treated With Prograf and Modified Release Tacrolimus
Status: COMPLETED
Conditions: Liver Transplantation
Interventions: DRUG: FK506E (modified release tacrolimus)|DRUG: Prograf (tacrolimus)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Does Vaginal Packing Influence Patient Outcomes Following Vaginal Reconstructive Surgery?
Status: COMPLETED
Conditions: Vaginal Packing Following Pelvic Reconstructive Surgery
Interventions: PROCEDURE: Vaginal packing|PROCEDURE: No vaginal packing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound to Assess Sarcopenia in Prader Willi Syndrome
Status: RECRUITING
Conditions: Prader-Willi Syndrome|Sarcopenia|Metabolic Syndrome
Interventions: DIAGNOSTIC_TEST: Ultrasound assessment of the right lower extremity muscles|DIAGNOSTIC_TEST: Dual-energy X-ray absorptiometry (DXA) scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Telerehabilitation vs. in Presence Rehabilitation of Reading Disorders Using the Rhythmic Reading Training (RRT)
Status: UNKNOWN
Conditions: Developmental Dyslexia
Interventions: BEHAVIORAL: In presence RRT - prototype software|BEHAVIORAL: In presence RRT - online platform|BEHAVIORAL: Tele-RRT - prototype software|BEHAVIORAL: Tele-RRT - online platform
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Verify the Efficacy of a Product Containing 125 mg of TetraSOD® for the Treatment of Male Infertility
Status: RECRUITING
Conditions: Male Infertility
Interventions: DIETARY_SUPPLEMENT: Sham|DIETARY_SUPPLEMENT: Marine microalgae Tetraselmis chuii with high Superoxide Dismutase (SOD) activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Cell Therapy in Chagas Cardiomyopathy
Status: TERMINATED
Conditions: Chagas Cardiomyopathy
Interventions: PROCEDURE: Stem cell|DRUG: Filgrastime (G-CSF)|DRUG: Standart therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study to Compare the Efficacy and Safety of HLX04-O With Ranibizumab in Subjects With wAMD
Status: ACTIVE_NOT_RECRUITING
Conditions: Age Related Macular Degeneration
Interventions: DRUG: HLX04-O|DRUG: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Dietary Changes on Gut-bacteria and Fibromyalgia Symptoms
Status: ACTIVE_NOT_RECRUITING
Conditions: Fibromyalgia|Diet, Gluten-Free
Interventions: BEHAVIORAL: Low-FODMAP diet|BEHAVIORAL: Gluten-free Diet|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ascension® Post- Approval Study; PyroCarbon Metacarpophalangeal Total Joint Prosthesis
Status: TERMINATED
Conditions: Rheumatoid Arthritis|Systemic Lupus Erythematosus|Osteoarthritis|Post-traumatic Arthritis
Interventions: DEVICE: Ascension® MCP Finger Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Macugen for Proliferative Diabetic Retinopathy Study With Extended Dosing (M-PDRS ED)
Status: UNKNOWN
Conditions: Proliferative Diabetic Retinopathy
Interventions: DRUG: Macugen ® (pegaptanib sodium)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gingival Crevicular Fluid Vaspin and Omentin Levels in Obese Patients With Chronic Periodontitis
Status: COMPLETED
Conditions: Obesity|Periodontitis
Interventions: OTHER: non surgical periodontal treatment|OTHER: Gingival crevicular fluid collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transanal Reinforcement of Low Rectal Anastomosis in Rectal Cancer Surgery
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: PROCEDURE: transanal anastomotic reinforcement|PROCEDURE: protective ileostomy group|DEVICE: a circular anal dilator (CAD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Muscle Delay Characterization
Status: COMPLETED
Conditions: Neurological Disorders
Interventions: DEVICE: Functional Electrical Stimulation (FES) Control Protocol|DEVICE: Functional Electrical Stimulation (FES) Angle Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Development of a Minimally Invasive Seizure Gauge
Status: UNKNOWN
Conditions: Epilepsy
Interventions: DEVICE: EpiTel Epilog|DEVICE: Empatica E4|DEVICE: GENEActiv
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Efficacy, Safety and Tolerability of IMU-838 as Addition to Investigator's Choice of Standard of Care Therapy, in Patients With Coronavirus Disease 19 (COVID-19)
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: IMU-838|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of SCH 697243 in Participants With Grass Pollen Allergy Symptoms, With or Without Asthma (P08067)
Status: COMPLETED
Conditions: Rhinitis Allergic|Conjunctivitis
Interventions: BIOLOGICAL: Grass (Phleum pratense) pollen allergen extract|BIOLOGICAL: Placebo for SCH 697243
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Vortioxetine (Lu AA21004) in Comparison to Agomelatine in Adults Suffering From Major Depression With Inadequate Response to Previous Medication
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Vortioxetine (Lu AA21004)|DRUG: Agomelatine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Swiss PACK-CXL Multicenter Trial for the Treatment of Infectious Keratitis
Status: COMPLETED
Conditions: Keratitis; Infectious Disease (Manifestation)
Interventions: DEVICE: PACK-CXL|DRUG: Cefazolin in combination with either tobramycin or gentamicin|DRUG: Cycloplegic agents (cyclopentolate 1% eye drops)|DRUG: Fluoroquinolones (Besifloxacin ; ciprofloxacin ; gatifloxacin ; levofloxacin ; moxifloxacin ; ofloxacin )|DRUG: Corticosteroids (prednisolone acetate 0.5% or 1% eye drops)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Assessment of Antibiotic Prophylaxis Prior to Port Placement
Status: WITHDRAWN
Conditions: Vascular Access Ports
Interventions: DRUG: Cefazolin|OTHER: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Placebo Effects on Blood Pressure
Status: UNKNOWN
Conditions: Blood Pressure
Interventions: OTHER: Placebo with BP dec (written form)|OTHER: Placebo with BP dec (doctor)|OTHER: Placebo with BP inc (written)|OTHER: Placebo with BP inc (doctor)|OTHER: Placebo info given (written)|OTHER: Placebo info given (doc)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Palbociclib in Combination With Bazedoxifene in Hormone Receptor Positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer Stage IV|Unresectable Locally Advanced Invasive Breast Cancer|Metastatic Invasive Breast Cancer
Interventions: DRUG: Palbociclib|DRUG: Bazedoxifene
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tarka® vs. Lotrel® in Hypertensive, Diabetic Subjects With Renal Disease (TANDEM)
Status: COMPLETED
Conditions: Hypertension|Diabetes|Proteinuria
Interventions: DRUG: trandolapril/verapamil|DRUG: Lotrel (amlodipine/benazepril)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tigulixostat, Phase 3 Study, Allopurinol Controlled in Gout Patients
Status: RECRUITING
Conditions: Gout|Hyperuricemia|Gout Flare|Tophi
Interventions: DRUG: Tigulixostat|DRUG: Allopurinol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ranger™ and Ranger™ SL (OTW) DCB) in China
Status: COMPLETED
Conditions: Femoropopliteal Artery Lesions
Interventions: DEVICE: Boston Scientific Ranger™ and Ranger™ SL Paclitaxel-Coated PTA Balloon Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Endovascular Access Trial (NEAT)
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DEVICE: The FLEX System will be used to percutaneously create a fistula in CKD patients who require hemodialysis vascular access
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rhythmic Auditory Stimulation and Walking Performance in Multiple Sclerosis (MS) Patients
Status: WITHDRAWN
Conditions: Gait Disturbance in Multiple Sclerosis Patients
Interventions: OTHER: Rhythmic auditory stimulation|OTHER: Walking exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Enzymatic Digestion and Probiotic on Oleuropein Bioavailability
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DIETARY_SUPPLEMENT: OLE enzymatically treated|DIETARY_SUPPLEMENT: OLE + probiotic|DIETARY_SUPPLEMENT: OLE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate Bleeding Patterns With Three Different Doses of DR-1031 Compared to Seasonale
Status: COMPLETED
Conditions: Breakthrough Bleeding
Interventions: DRUG: DR-1031|DRUG: Seasonale®|DRUG: Portia®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Assess the Efficacy of Pembrolizumab Plus Radiotherapy or Ablation in Metastatic Colorectal Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Pembrolizumab|RADIATION: Radiotherapy|PROCEDURE: Radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Stem Cell Transplantation for Refractory Systemic Lupus Erythematosus (ASSIST)
Status: UNKNOWN
Conditions: Systemic Lupus Erythematosus
Interventions: PROCEDURE: Immunoablation and Autologous Hematopoietic Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Root Coverage in Smokers With Acellular Dermal Matrix Graft and Enamel Matrix Derivative
Status: COMPLETED
Conditions: Gingival Recession
Interventions: DRUG: acellular dermal matrix graft|DRUG: enamel matrix derivative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: B-slim, a Multi-source Digital Super Coach for Sustainable Weight Loss
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: Digital Super Coach|OTHER: Conventional face to face PA & dietitian|OTHER: Digital Super Coach + minimal coaching|OTHER: Waiting Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Green Tea Extract for Endometriosis Treatment
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: SUNPHENON EGCg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab Plus 177Lu-PSMA-617 in Patients With Castration Resistant Prostate Cancer
Status: RECRUITING
Conditions: Castrate Resistant Prostate Cancer|Metastatic Castration-resistant Prostate Cancer|Prostate Cancer|Prostate Carcinoma
Interventions: DRUG: Pembrolizumab|DRUG: 177Lu-PSMA-617
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes|Diabetic Nephropathy|Diabetic Kidney Disease
Interventions: DRUG: sodium bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Efficacy, Safety, and Tolerability Study of Natalizumab in Focal Epilepsy
Status: COMPLETED
Conditions: Epilepsy, Focal Seizures, Partial Seizures
Interventions: DRUG: Natalizumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Morbidity in Open Versus Minimally Invasive Esophagectomy
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: PROCEDURE: minimally invasive esophagectomy|PROCEDURE: open esophagectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iodine I 131 Monoclonal Antibody BC8 Before Autologous Stem Cell Transplant in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma
Status: TERMINATED
Conditions: Recurrent B-Cell Non-Hodgkin Lymphoma|Recurrent Hodgkin Lymphoma|Recurrent T-Cell Non-Hodgkin Lymphoma|Refractory B-Cell Non-Hodgkin Lymphoma|Refractory Hodgkin Lymphoma|Refractory T-Cell Non-Hodgkin Lymphoma
Interventions: PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation|RADIATION: Iodine I 131 Monoclonal Antibody BC8|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile Strategies for Women's and Children's Health: Optimizing Adherence and Efficacy of PMTCT/ART
Status: COMPLETED
Conditions: mHealth|PMTCT|Adherence, Medication|SMS|Maternal Health|HIV/AIDS
Interventions: BEHAVIORAL: SMS messaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Trial of TQC3721 Suspension for Inhalation in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease.
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: TQC3721 suspension for inhalation|DRUG: TQC3721 matching placebo for inhalation|DRUG: Salbutamol sulfate inhalation aerosol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carboplatin-Paclitaxel ± Bevacizumab in Advanced (Stage III-IV) or Recurrent Endometrial Cancer
Status: UNKNOWN
Conditions: Stage III-IV or Recurrent Endometrial Cancer
Interventions: DRUG: Bevacizumab|DRUG: Carboplatin AUC 5+Paclitaxel 175 mg/mq q 21 for 6-8 cycles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Using of NEurocryostimulation in Military Ankle Sprains
Status: UNKNOWN
Conditions: Sprain of Lateral Ligament of Ankle Joint
Interventions: DEVICE: neurocryostimulation with Duo-cryo® device|DEVICE: cryotherapy with Cold pack® or ice-cubes pack
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deciphering the Role of Oxytocin in Motivation: an fMRI Study
Status: COMPLETED
Conditions: Focus of Study: Neural Correlates of Oxytocin Administration
Interventions: DRUG: Placebo|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hallux Abductus Valgus and Extensor Hallux Longus; Treatment by MIS Surgery
Status: RECRUITING
Conditions: Hallux Valgus and Bunion
Interventions: PROCEDURE: Minimally invasive procedures for the Hallux Abductus Valgus.|PROCEDURE: Minimally invasive procedures for the Hallux Abductus Valgus and a zig-zag tenotomy for the extensus hallux longus.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Psoas Sciatic Blockade for Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: Bupivacaine 0.25%|OTHER: Pajunk Needle|OTHER: Portex combined spinal epidural kit|DRUG: Lidocaine 1%|DRUG: Bupivacaine 0.5%|DRUG: Lidocaine 2 %|DRUG: Bupivacaine 0.125 %
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Localized Treatment Versus Palliative Chemotherapy in CRC Patients With 10 or More CRLM
Status: RECRUITING
Conditions: Colorectal Neoplasms Malignant
Interventions: PROCEDURE: Surgical resection and/or ablation therapy and/or SBRT|DRUG: Palliative Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Fluoride Varnish on White Spot Lesion in Clear Aligner Orthodontic Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: White Spot Lesion
Interventions: OTHER: Fluoride varnsh|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Feasibility of Using Augmented Reality in Laparoscopic Surgery, by a Clinical Study During Gynecological Laparoscopic Surgical Procedures. (ENDORA2)
Status: RECRUITING
Conditions: Myoma;Uterus|Adenomyoma of Uterus
Interventions: DEVICE: Laparoscopic surgery with augmented reality device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lidocaine Patch 1.8% for Moderate to Severe Pain From Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: DRUG: Lidocaine 1.8%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of HAIC With FOLFOX vs Sorafenib for Patients Who Showed TACE-resistant: a Retrospective Study
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: HAIC|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of GnRH Agonist vs GnRH Antagonist on IVF/ICSI Outcomes in Polycystic Ovary Syndrome Patients.
Status: COMPLETED
Conditions: In Vitro Fertilization|Intracytoplasmic Sperm Injection|Infertility|Polycystic Ovary Syndrome
Interventions: DRUG: Triptorelin acetate|DRUG: Cetrorelix|DRUG: recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin|DRUG: Human Chorionic Gonadotropin (hCG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Niraparib Combined With Bevacizumab in Platinum Refractory/Resistant Recurrent Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Neoplasms|Fallopian Tube Neoplasms|Endocrine Gland Neoplasms|Neoplasms by Site|Neoplasms|Genital Neoplasms, Female|Urogenital Neoplasms|Neoplasms, Glandular and Epithelial|Neoplasms by Histologic Type|Carcinoma, Ovarian Epithelial|Ovarian Diseases|Adnexal Diseases|Genital Diseases, Female|Endocrine System Diseases|Gonadal Disorders|Carcinoma|Bevacizumab|Enzyme Inhibitors|Antineoplastic Agents|Molecular Mechanisms of Pharmacological Action|Angiogenesis|BRCA1 Mutation|BRCA2 Mutation|Homologous Recombination Deficiency
Interventions: DRUG: Niraparib|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coordinated, Collaborative, Comprehensive, Family-based, Integrated, Technology-enabled Stroke Care
Status: ACTIVE_NOT_RECRUITING
Conditions: Stroke|Stroke, Ischemic|Stroke, Acute|Stroke Sequelae|Engagement, Patient|Stroke Hemorrhagic
Interventions: OTHER: Integrated Stroke Practice Unit|OTHER: Comprehensive or Primary Stroke Center
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: First Line Hepato Cellular Carcinoma (HCC)
Status: COMPLETED
Conditions: Hepato Cellular Carcinoma (HCC)
Interventions: DRUG: Brivanib|DRUG: Placebo|DRUG: Sorafenib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy Study of Hutox Versus Botox® in Subject With Moderate to Severe Glabellar Lines
Status: UNKNOWN
Conditions: Glabellar Frown Lines
Interventions: BIOLOGICAL: Hutox Inj|BIOLOGICAL: Botox Inj
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colonoscopy Preparation Optimization for INpatients- COIN Study
Status: UNKNOWN
Conditions: Endoscopy|Bowel Preparation Solutions
Interventions: DRUG: Bisacodyl 10mg|DRUG: Polyethelene Glycol|DRUG: Picosulfate sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Carotenoid Supplementation and Normal Ocular Health
Status: COMPLETED
Conditions: Retinal Ageing
Interventions: DIETARY_SUPPLEMENT: VisionAce|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of an Aquatic Therapy Program Versus a Land Program in Patients Who Suffered a Stroke
Status: COMPLETED
Conditions: Stroke|Hydrotherapy
Interventions: OTHER: circuit class therapy in water|OTHER: circuit class therapy on land
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Telehealth Study of a Wearable Electroceutical & Sports Sleeve for Knee Osteoarthritis Pain Relief & Improved Function
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: HEAL-122 microcurrent electroceutical with e-textile sports knee sleeve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study to Assess Irritation, Sensitization and Adhesion of a Novel Ibuprofen 200 mg TEPI Medicated Plaster
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ibuprofen 200 mg TEPI Medicated Plaster|OTHER: Placebo TEPI Plaster
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Insulin Pump Treatment and Multiple Daily Insulin Injections in Diabetic Type 1 Children
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Child
Interventions: DEVICE: Insulin pump (CSII)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effects of Motor Cognitive Dual Task Exercises on Cognitive Function, Balance and Functional Capacity in Patients Who Have Undergone Liver Transplantation.
Status: RECRUITING
Conditions: Liver Transplantation
Interventions: OTHER: exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dose Ranging Study of the GLP-1 Agonist AVE0010 in Metformin-Treated Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: LIXISENATIDE (AVE0010)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Daratumumab in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome
Status: TERMINATED
Conditions: High Risk Myelodysplastic Syndrome|Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: BIOLOGICAL: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of the Early Introduction of Everolimus (Certican®) With Low Dose of Cyclosporine in de Novo Kidney Recipients After 1 Month of Transplantation
Status: COMPLETED
Conditions: Planned Kidney Transplantation
Interventions: DRUG: Everolimus + Low dose CsA +PD|DRUG: Myfortic+ Standard CsA + PD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain in Parkinson's Disease With Motor Fluctuations.
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: DRUG: safinamide metansolfonato (12 weeks)|DRUG: safinamide metansolfonato (12 weeks)|DRUG: rasagilina mesilato (12 weeks)|DRUG: rasagilina mesilato (12 weeks)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Induction Chemotherapy With Nab-paclitaxel, Cisplatin and Fluorouracil for Locoregionally Advanced Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma|Nasopharyngeal Cancer|Nasopharynx Cancer
Interventions: DRUG: Nab-paclitaxel, Cisplatin and Fluorouracil|RADIATION: concurrent chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Open-Label Study of the Absorption, Metabolism, Excretion and Absolute Bioavailability of ALS-008176
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: DRUG: ALS-008176|DRUG: ALS-008112
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reversal of the Anti-platelet Effects of Ticagrelor
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Ticagrelor|DRUG: Aspirin + Ticagrelor|DRUG: Control|DRUG: Aspirin + Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Structured Peer-delivered ART and Reentry Community Strategy
Status: NOT_YET_RECRUITING
Conditions: Retention in Care
Interventions: BEHAVIORAL: Group SPARCS Intervention|BEHAVIORAL: ART-SPARCS Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Foley Catheter Versus Vaginal Misoprostol for Cervical Ripening and Induction of Labor
Status: COMPLETED
Conditions: Pregnancy, Prolonged|Pre Eclampsia|Oligohydramnios
Interventions: DRUG: Misoprostol|DEVICE: Foley
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamics and Autonomic and Cognitive Performance After Carotid Revascularization Procedures
Status: COMPLETED
Conditions: Carotid Artery Diseases
Interventions: PROCEDURE: Carotid revascularization performed using CAS|PROCEDURE: Carotid revascularization performed using CEA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Use of a Contraceptive Decision Aid and Patient Outcomes
Status: NOT_YET_RECRUITING
Conditions: Contraceptive Usage
Interventions: BEHAVIORAL: Tuune Supplemented Contraceptive Visit|BEHAVIORAL: Traditional Contraceptive Visit
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 2 Study of the Safety and Efficacy of Thymosin Beta 4 for Treating Corneal Wounds
Status: TERMINATED
Conditions: Diabetes
Interventions: DRUG: Thymosin Beta 4 (Tβ4)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Treatment of Camrelizumab and Bevacizumab for Adult Patients With Recurrent Glioblastoma (GBM)
Status: SUSPENDED
Conditions: Recurrent Glioblastoma
Interventions: DRUG: Camrelizumab and Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT