pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Initiation of Resuscitation While Attached to the Cord With Congenital Heart Disease
Status: WITHDRAWN
Conditions: Congential Absence of Heart Structure|Congenital Malformation of Heart, Unspecified|Hypoplastic Left Heart Syndrome|TGA - Transposition of Great Arteries|Hypoplastic Right Heart Syndrome|Congential Malformations of Aortic Valve|Congenital Heart Defect|Congential Malformations of Great Arteries
Interventions: PROCEDURE: Initiation of Resuscitation While Attached to the Cord
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 3D MR Versus 3D CT for Glenohumeral Arthritis
Status: COMPLETED
Conditions: Arthritis|Glenohumeral Osteoarthritis
Interventions: DIAGNOSTIC_TEST: 3-dimensional (3D) magnetic resonance (MR) imaging|DIAGNOSTIC_TEST: 3D computed tomography (CT) imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prophylactic Use of Maribavir for the Prevention of Cytomegalovirus (CMV) Disease in Stem Cell Transplant Recipients
Status: COMPLETED
Conditions: Cytomegalovirus Infections
Interventions: DRUG: maribavir|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Effect of omega3 on Biomarkers of Cardiac Necrosis (CKMB and Troponin I) and Inflammation Marker (CRP) After Elective Percutaneous Coronary Intervention (PCI)
Status: COMPLETED
Conditions: Coronary Arteriosclerosis
Interventions: DRUG: omega 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety/Efficacy Study of Subcutaneously Injected Prandial Insulins Compared to Insulin Lispro Alone in Participants With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Insulin lispro|DRUG: recombinant human hyaluronidase PH20|DRUG: Insulin aspart|DRUG: Insulin glulisine|DRUG: Insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pre-operative Oral Pregabalin in Ambulatory Inguinal Hernia Repair for Post Operative Pain
Status: UNKNOWN
Conditions: Inguinal Hernia|Postoperative Pain
Interventions: DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Cloxacillin and Fosfomycin Combination Versus Cloxacillin Monotherapy in Patients With MSSA Bacteremia
Status: TERMINATED
Conditions: Methicillin Susceptible Staphylococcus Aureus Septicemia
Interventions: DRUG: Combination therapy group|DRUG: Standard therapy group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Boric Acid in Combination With Probiotics for the Treatment of Vaginal Infections
Status: COMPLETED
Conditions: Candidiasis|Vaginosis, Bacterial
Interventions: DEVICE: Boric acid and probiotics|DRUG: Antibiotic (Clindamycin)|DRUG: Antifungal (Clotrimazole)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Augmenting Rehabilitation Outcomes and Functional Neuroplasticity Using Epidural Stimulation of Cervical Spinal Cord
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injuries|Cervical Spinal Cord Injury
Interventions: DEVICE: Epidural Spinal Stimulation (ESS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Telaglenastat (CB-839) in Combination With Palbociclib in Patients With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors|NSCLC|CRC|KRAS Gene Mutation
Interventions: DRUG: Telaglenestat (CB-839)|DRUG: Palbociclib Oral Capsule or Tablet [Ibrance]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antiplatelet Therapy Effect on Extracellular Vesicles in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Propofol and Sevoflurane for Catheter-Related Bladder Discomfort
Status: COMPLETED
Conditions: Catheter Site Discomfort|Complications|Anesthesia|Urinary Bladder Neoplasms
Interventions: DRUG: Propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TRANSPIRE: Lung Injury in a Longitudinal Cohort of Pediatric HSCT Patients
Status: RECRUITING
Conditions: Hematopoietic Stem Cell Transplant (HSCT)|Diffuse Alveolar Hemorrhage|Thrombotic Microangiopathies|Interstitial Pneumonitis|Bronchiolitis Obliterans
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Outcomes Following Tourniquet and Non-Tourniquet Assisted Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: OTHER: Total Knee Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Subcutaneous Mircera and Darbepoetin Alfa for Maintenance Treatment of Anemia in Kidney Transplant Recipients.
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Darbepoetin alfa|DRUG: methoxy polyethylene glycol-epoetin beta [Mircera]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Proton Pump Inhibitors on Calcium and Bone Metabolism
Status: COMPLETED
Conditions: Calcium Metabolism Disorders
Interventions: DRUG: Rabeprazole or Esomeprazole or Lanzoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Motivation-Oriented Versus Psychoeducation-Oriented Day Hospital Treatment for Eating Disorders
Status: COMPLETED
Conditions: Motivational Interviewing|Psychoeducation
Interventions: BEHAVIORAL: Motivational Orientated Treatment|BEHAVIORAL: Psychoeducation-Oriented Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rotation or Change of Biotherapy After TNF Blocker Treatment Failure for Axial Spondyloarthritis
Status: RECRUITING
Conditions: Axial Spondyloarthritis
Interventions: DRUG: Secukinumab|DRUG: TNF blocker|BIOLOGICAL: blood specimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Plasma Gelsolin in Healthy Volunteers
Status: COMPLETED
Conditions: Volunteers|Healthy
Interventions: DRUG: Recombinant human plasma gelsolin|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characteristics of Popliteal Sciatic Nerve Block in Patients With and Without Diabetic Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathy
Interventions: PROCEDURE: US-guided sciatic block at the popliteal crease (30 mL1:1 mixture of lidocaine 1% and bupivacaine 0.5%)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PediCARE Health Equity Intervention in High-Risk Neuroblastoma
Status: WITHDRAWN
Conditions: Neuroblastoma|High-risk Neuroblastoma|Pediatric Cancer|Disparities|Financial Stress|Poverty
Interventions: BEHAVIORAL: PediCARE Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dexmedetomidine Versus Pentobarbital for Pediatric Procedural Sedation
Status: WITHDRAWN
Conditions: Sedation
Interventions: DRUG: dexmedetomidine sedation protocol|DRUG: pentobarbital sedation protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: PD-1 Inhibitor Combined With Neoadjuvant Chemotherapy in Subjects With Resectable Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Esophageal Neoplasms|Esophageal Squamous Cell Carcinoma
Interventions: DRUG: PD-1 inhibitor|DRUG: Albumin-Bound Paclitaxel|DRUG: Cisplatin|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Vortic Catch V Basket Catheter and Ordinary Basket Catheter for the Removal of Bile Duct Stones
Status: RECRUITING
Conditions: Randomized Study
Interventions: DEVICE: bile duct stone removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: In Silico Study Assessing the Impact of Inclisiran on Major Adverse Cardiovascular Events in Patients With Established Cardiovascular Disease
Status: COMPLETED
Conditions: Atherosclerotic Cardiovascular Disease
Interventions: DRUG: Inclisiran sodium|DRUG: Placebo|DRUG: Ezetimibe|DRUG: Evolocumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Correlation Between Pressure Differences and Micro-vascularization Changes in Bedridden Paraplegic Patient
Status: TERMINATED
Conditions: Pressure Ulcer|Bedsore|Spinal Cord Injury|Paraplegia
Interventions: OTHER: Measurement of interface pressure|OTHER: Measurement of micro-vascularization related parameters
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Delirium Evaluation Tools Effectiveness in Intensive Care Patients
Status: COMPLETED
Conditions: Delirium
Interventions: OTHER: Delirium prediction model for ICU patients, version 1|OTHER: Delirium prediction model for ICU patients, version 2|OTHER: Early prediction model for delirium in ICU patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ultrasound Guided Interventions of Calcific Tendonitis of Rotator Cuff (SUCTION)
Status: UNKNOWN
Conditions: Rotator Cuff Calcific Tendonitis
Interventions: OTHER: Ultrasound guided Needle Fragmentation|OTHER: US guided needle fragmentation & Lavage|OTHER: Ultrasound guided subacromial injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Lung Protective Ventilation in Pulmonary Thromboendarterectomy (PTE) Patients
Status: COMPLETED
Conditions: Chronic Thromboembolic Pulmonary Hypertension|Acute Lung Injury
Interventions: OTHER: Ventilation Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Observance of Continuous Positive Pressure for the Treatment of Obstructive Sleep Apnea Syndrome
Status: RECRUITING
Conditions: Obstructive Sleep Apnea Syndrome|Continuous Positive Airway Pressure|Adherence|Perception and Beliefs
Interventions: OTHER: questionary
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prevention of Perioperative Pulmonary Complications by Lung Recruitment During Laparoscopic Surgery
Status: UNKNOWN
Conditions: Perioperative Complication|Hypoxia
Interventions: PROCEDURE: lung recruitment|PROCEDURE: Standard ventilatory management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Diabetic Foot Wound Healing Using Hydrogel/Nano Silver-based Dressing vs. Traditional Dressing
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: PROCEDURE: Hydrogel/nano silver-based dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Positron Emission Tomography (PET) Imaging With Zirconium-89 (89Zr)-Trastuzumab for Prediction of HER2 Targeted Therapy Effectiveness
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: [89Zr]-Df-Trastuzumab|DIAGNOSTIC_TEST: PET/MRI Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluate the Efficacy and Safety of AYP-101 for the Reduction of Submental Fat in Chin Area
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: Polyene Phosphatidylcholine|DRUG: Matching placebo of AYP-101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Short Term Effects of Electronic Cigarettes in Tobacco Dependent Adults
Status: COMPLETED
Conditions: Smoking|Nicotine Dependence
Interventions: OTHER: Nicotine e-cigarette|OTHER: Non-nicotine e-cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of Pharmacist's Intervention in Improving Treatment Outcomes of Rheumatoid Arthritis: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: OTHER: Pharmacist led pharmaceutical care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Individual Acceptance and Commitment Therapy (ACT) for Smoking Cessation for Schizophrenic Patients
Status: UNKNOWN
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Acceptance and commitment therapy|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Are Rehabilitation Results in Flexor Tendon Zone II Injuries as Bad as Feared?
Status: COMPLETED
Conditions: Flexor Tendon Rupture|Hand Injuries|Rehabilitation
Interventions: OTHER: rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Normalization of Eating Intervention Program for Treating Women With Eating Disorders
Status: COMPLETED
Conditions: Eating Disorders
Interventions: BEHAVIORAL: Normalization of Eating (NOE)|BEHAVIORAL: Treatment As Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Nursing Triage Protocol for Minor Orthopedic Traumata: the Effect on Flow Time, Quality of Care and Patient Satisfaction in an Emergency Department
Status: COMPLETED
Conditions: Trauma Injury
Interventions: DIAGNOSTIC_TEST: Nursing triage protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Treatment of Premature Infants With Brain Injury by Autologous Umbilical Cord Blood Stem Cells
Status: UNKNOWN
Conditions: Safety Issues|Effect of Drugs
Interventions: OTHER: autologous umbilical cord blood stem cells|DRUG: 0.9% Sodium-chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of a New Neuroimaging Method Aimed to Differentiate Mnesic Abilities of Alzheimer and Depressed Patients
Status: UNKNOWN
Conditions: Alzheimer Disease|Depression
Interventions: DEVICE: high-density electroencephalography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bevacizumab With Pelvic Radiotherapy And Primary Chemotherapy in Patients With Poor-Risk Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: RADIATION: Radiation therapy|DRUG: Oxaliplatin|DRUG: Raltitrexed|DRUG: levofolinic acid|DRUG: 5-fluorouracil|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dihydroartemisinin-Piperaquine in the Context of Antiretroviral Therapy
Status: COMPLETED
Conditions: Drug-Drug Interaction|HIV Infection
Interventions: DRUG: Dihydroartemisinin-piperaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: SCRT Followed by Camrelizumab Combined With Fluzoparib and Chemotherapy as Neoadjuvant Therapy for LARC
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: RADIATION: SCRT|DRUG: Camrelizumab|DRUG: Fluzoparib|DRUG: CAPEOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial Comparing Short-Term Efficacy and Safety of Exubera and Lantus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Inhaled Human Insulin (Exubera)|DRUG: Insulin Glargine (Lantus)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Measurement of Quadriceps Shortening During Neuromuscular Electrical Stimulation in Critically Ill Patients
Status: COMPLETED
Conditions: ICU Acquired Weakness|Quadriceps Muscle Atrophy
Interventions: DIAGNOSTIC_TEST: Early ultrasound measurement of quadriceps shortening during neuromuscular electrical stimulation (NMES)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lopinavir and Ritonavir in Improving Immune Response to Vaccines in Patients With Complete Remission Following A Bone Marrow Transplant for Hodgkin Lymphoma
Status: WITHDRAWN
Conditions: Hodgkin Lymphoma|Stage I Adult Hodgkin Lymphoma|Stage II Adult Hodgkin Lymphoma|Stage III Adult Hodgkin Lymphoma|Stage IV Adult Hodgkin Lymphoma
Interventions: DRUG: lopinavir|DRUG: ritonavir|GENETIC: polymerase chain reaction|OTHER: flow cytometry|OTHER: enzyme-linked immunosorbent assay|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assess the Safety & Immunogenicity of Prime-Boost Vaccination Strategies Using H5Nx Virus Vaccine Adjuvanted With AS03 or MF59
Status: COMPLETED
Conditions: Influenza A Virus, H5N1 Subtype
Interventions: BIOLOGICAL: VN|BIOLOGICAL: IN|BIOLOGICAL: dk/BANG|BIOLOGICAL: gf/WA|BIOLOGICAL: bhg/QL|BIOLOGICAL: AS03 adjuvant|BIOLOGICAL: MF59 adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety Study for the Use of Rapamycin in Children With Familial Adenomatous Polyposis
Status: NOT_YET_RECRUITING
Conditions: Familial Adenomatous Polyposis
Interventions: DRUG: Rapamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Use of Vibrators With Vaginal Dilators for Vaginismus. (Vibrator Therapy and Dilators in Vaginismus)
Status: COMPLETED
Conditions: Vaginismus
Interventions: OTHER: External Vibrator - patient-administered.|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Safety and Potential Efficacy of LT3001 Drug Product in Subjects With AIS
Status: UNKNOWN
Conditions: Acute Ischemic Stroke
Interventions: DRUG: LT3001 Drug Product|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proton Beam Radiation Therapy for Intraocular and Periocular Retinoblastoma
Status: TERMINATED
Conditions: Retinoblastoma
Interventions: RADIATION: Proton Beam Radiation Therapy|PROCEDURE: Ophthalmic EUA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Patient Position on Attenuation Artifacts Observed in D-SPECT Camera Myocardial Tomoscintigraphy
Status: UNKNOWN
Conditions: Attenuation Artifact|Myocardial Tomoscintigraphy|Patient Position
Interventions: PROCEDURE: Rest tomoscintigraphy in forward tilted|PROCEDURE: Rest tomoscintigraphy in semi sitting position|PROCEDURE: Rest tomoscintigraphy in dorsal decubitus position
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Medical Research Study to Evaluate the Effects of ACT-246475 in Adults With Heart Attack
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Selatogrel 8 mg|DRUG: Selatogrel 16 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NURSE-led Follow-up in Patients Undergoing CATheter Ablation for Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: BEHAVIORAL: educational program|BEHAVIORAL: risk factors management|BEHAVIORAL: telephone and e-mail contact|OTHER: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Continous Regional Anesthesia Using m. Erector Spinae Catheter After VATS Procedures
Status: UNKNOWN
Conditions: Neoplasm of Lung|Thoracic Surgery, Video-Assisted
Interventions: DRUG: Ropivacaine Hcl 0.2% Inj Vil 10Ml|DRUG: Saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Recovery Profiles Among Propofol, Remimazolam, and Dexmedetomidine After Intraoperative Sedation
Status: COMPLETED
Conditions: Remimazolam|Propofol|Dexmedetomidine|Orthopedic Procedures|Sedatives|Brachial Plexus Block
Interventions: DRUG: Remimazolam|DRUG: Propofol|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Inflammatory Response in Post-operated Aortic Valve Replacement Patients.
Status: COMPLETED
Conditions: Aortic Valve Disease|Aortic Valve Stenosis|Aortic Valve Calcification|Prosthetic Valve Malfunction
Interventions: DIAGNOSTIC_TEST: Determination of cytokines|DIAGNOSTIC_TEST: Two-dimensional transthoracic echocardiogram
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Emergency Treatment of Coral Snake Envenomation With Antivenom
Status: COMPLETED
Conditions: Coral Snake Bite|Toxic Effect of Coral Snake Venom
Interventions: DRUG: Snake (Micrurus) North American immune F(ab')2 Equine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Vitamin D Encapsulated in Casein Micelles, Compared to Its Bioavailability in a Synthetic Emulsifier Currently Used for Supplementation and Enrichment.
Status: UNKNOWN
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: enriched skimmilk with VD|DIETARY_SUPPLEMENT: Skimmilk enriched with VD wherein the VD will be emulsified using Tween 80|DIETARY_SUPPLEMENT: Placebo: un-enriched skimmilk.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Laparoscopic Single Anastomosis Sleeve Ileal Bypass Versus Laparoscopic Sleeve Gastrectomy For Morbidly Obese Patients
Status: UNKNOWN
Conditions: Bariatric Surgery
Interventions: PROCEDURE: Laparoscopic single anastomosis sleeve ileal bypass|PROCEDURE: Laparoscopic sleeve gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Pharmacokinetics of AC 1202 and Two Doses of AC-SD-01 on Ketone Body Production
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AC-1202|DRUG: AC-SD-01 (50 g)|DRUG: AC-SD-01 (75 g)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A MultIceNTER Phase I Peptide VaCcine Trial for the Treatment of H3-Mutated Gliomas
Status: RECRUITING
Conditions: Newly Diagnosed H3-mutated Glioma
Interventions: DRUG: Tecentriq 1200 MG in 20 ML Injection|BIOLOGICAL: H3K27M peptide vaccine|OTHER: Imiquimod (5%)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Levonorgestrel-releasing Intrauterine System in Patients With Endometriosis
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: LNG-IUS: levonorgestrel intrauterine system|DRUG: GnRHa: leuprolide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Comparison of the Effects of Oxycodone Versus Fentanyl on Airway Reflex to Tracheal Extubation and Postoperative Pain
Status: COMPLETED
Conditions: Coughing Responses at Tracheal Extubation
Interventions: DRUG: fentanyl|DRUG: Oxycodone|DRUG: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Apixaban in the Treatment of Heparin Induced Thrombocytopenia (HIT)
Status: TERMINATED
Conditions: Heparin-induced Thrombocytopenia|Heparin-induced Thrombocytopenia and Thrombosis
Interventions: DRUG: Apixaban
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Outcome in Two Types of Total Knee Replacement Surgery for People With Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: PROCEDURE: Mid-vastus approach|PROCEDURE: medial parapatellar approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Study to Investigate the Pharmacokinetics (PK) and Safety of Belimumab 200 Milligrams (mg) Intravenous and 200 mg Subcutaneous Via Auto-injector in Chinese Healthy Subjects
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Belimumab for IV|DRUG: Belimumab for SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease|Obstructive Sleep Apnea|Overweight and Obesity
Interventions: OTHER: FOCuSEd Integrated Intervention|OTHER: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acupressure Application in Obesity Surgery 2345
Status: COMPLETED
Conditions: Acupressure|Bariatric Surgery|Spleen Meridian|Pregnancy Meridian|Stomach Meridian
Interventions: BEHAVIORAL: acupressure|BEHAVIORAL: Area different from acupressure area
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preventing Pneumonia and Other Respiratory Problems in Persons With Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: BEHAVIORAL: Manual and mechanical assisted cough|BEHAVIORAL: Incentive spirometry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Vitamin D Plus Omega-3 Polyunsaturated Fatty Acids in Patients With Episodic Migraine
Status: RECRUITING
Conditions: Episodic Migraine
Interventions: DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: Non-Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness and Safety of BIO-11006 Inhalation Solution to Treat the Overproduction of Mucus and Inflammation in COPD
Status: COMPLETED
Conditions: COPD|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: BIO-11006 Inhalation Solution|DRUG: BIO-11006 Inhalation Solution|DRUG: BIO-11006 Inhalation Solution|DRUG: Placebo|DRUG: BIO-11006
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Incidence of Post-operative Pain After Single-visit Versus Two-visit Treatment
Status: COMPLETED
Conditions: Post-operative Pain
Interventions: PROCEDURE: One visit RCT|PROCEDURE: Post operative pain in two-visits RCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Identification of Molecular Marker of Coagulase-negative Staphylococci for the Diagnosis of Prosthetic Joint Infections
Status: UNKNOWN
Conditions: Prosthetic Joint Infection
Interventions: OTHER: Proteomic analysis of synovial fluids|OTHER: Proteomic analysis of the isolated coagulase-negative Staphylococci
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of RO7589831 in Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: RO7589831
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cetuximab/FOLFIRI With or Without Oxaliplatin and FOLFOXIRI With or Without Bevacizumab in Neoadjuvant Treatment of Non-resectable Colorectal Liver Metastases
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: Cetuximab|DRUG: Bevacizumab|DRUG: Irinotecan|DRUG: Oxaliplatin|DRUG: 5-FU|DRUG: Folinic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eye-Tracking FP "A Pilot Study of the Quantitative Evaluation of the Attention Paid to Faces With Facial Palsy by the Eye-tracking Technology.
Status: RECRUITING
Conditions: Eye-tracking|Facial Palsy
Interventions: OTHER: Video sequences
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluating and Improving Functional Driving Vision of Patients With Astigmatism: Phase 3
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: Placebo Lenses|DEVICE: Spherical Lenses|DEVICE: Toric Lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biological Bone Markers and Hydrolyzed Collagen Supplement in Menopausal Healthy Women
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DIETARY_SUPPLEMENT: hydrolyzed collagen|DIETARY_SUPPLEMENT: wheat protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Registry of Subjects With Drug Resistant Epilepsy and Treated With the VNS Therapy System.
Status: ACTIVE_NOT_RECRUITING
Conditions: Epilepsy|Seizures|Drug Resistant Epilepsy
Interventions: DEVICE: Vagus Nerve Stimulation (VNS) Therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence Study Of Diltiazem In 60 Mg Tablets As Tilazem 60® Made by Pfizer, S.A. De C.V., Versus Angiotrofin® 60 Mg Made by Amstrong Laboratorios De Mexico, S.A. De C.V.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: TILACEM|DRUG: ANGIOTROFIN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Study to Evaluate the Testicular Safety of Filgotinib in Adult Males With Moderately to Severely Active Inflammatory Bowel Disease
Status: TERMINATED
Conditions: Inflammatory Bowel Disease
Interventions: DRUG: Filgotinib|DRUG: Placebo|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Gene Polymorphisms on GLP-1 Receptor Agonists Response in Patients With T2DM
Status: RECRUITING
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: GLP-1 receptor agonist
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Cultural Formulation Interview-Engagement Aid
Status: COMPLETED
Conditions: Communication|Adherence, Patient
Interventions: BEHAVIORAL: The Cultural Formulation Interview-Engagement Aid|BEHAVIORAL: The Cultural Formulation Interview-Engagement Aid (Revised)|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Dermacyd PH_DESILSTY_FR (Lactic Acid) - Acceptability - Stay on Frutal
Status: COMPLETED
Conditions: Hygiene
Interventions: DRUG: LACTIC ACID(ND)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of MORF 057 to Evaluate Single and Multi Ascending Doses in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: MORF-057|DRUG: Placebo for MORF-057
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A 12-Week Study to Evaluate the Efficacy of Darifenacin to Increase the Warning Time in Patients With Overactive Bladder.
Status: COMPLETED
Conditions: Overactive Bladder Syndrome
Interventions: DRUG: Darifenacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Shockwave Lithotripsy (SWL) Versus SWL and Oral Dissolution Therapy (ODT) For Paediatrics Radiolucent Renal Stone
Status: COMPLETED
Conditions: Pediatric Kidney Disease
Interventions: DEVICE: SWL|COMBINATION_PRODUCT: SWL and ODT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adductor Canal Block
Status: ENROLLING_BY_INVITATION
Conditions: Osteoarthritis|Total Knee Replacement
Interventions: DRUG: Ropivacaine injection|DRUG: Saline Injection|PROCEDURE: Total Knee Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Post-instrumentation Pain After Use of the Fanta and M3 Pro Gold Systems
Status: COMPLETED
Conditions: Endodontic Treatment
Interventions: PROCEDURE: Fanta (Pepsi gold) (FPG)|PROCEDURE: M3-pro+ Gold (assorted) (MPG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Radiosurgery Plus Bevacizumab in Glioblastoma
Status: TERMINATED
Conditions: Glioblastoma|Gliosarcoma|Brain Tumor
Interventions: RADIATION: radiosurgery|BIOLOGICAL: bevacizumab|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cells (MSCs) for Treatment of Acute Respiratory Distress Syndrome (ARD) in Patients With Malignancies
Status: COMPLETED
Conditions: Blood And Marrow Transplantation|Adult Respiratory Distress Syndrome
Interventions: BIOLOGICAL: Mesenchymal Stem Cells (MSCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Explore the Safety and Efficacy of Injections of Macugen When Given Every 6 Weeks in Subjects With AMD
Status: UNKNOWN
Conditions: Age-Related Macular Degeneration (AMD)
Interventions: DRUG: pegaptanib sodium (Macugen)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Variceal Rebleeding by EUS-guided vs Conventional Endoscopic Therapy in Hepatocellular Carcinoma Patients
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Variceal Bleeding
Interventions: PROCEDURE: endoscopic ultrasound-guided therapy|PROCEDURE: conventional endoscopic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: myHealthHub for Older Adult Inpatients
Status: UNKNOWN
Conditions: Patient Engagement|Stress|Loneliness|Quality of Life
Interventions: DEVICE: myHealthHub|DEVICE: TV-only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy Study of CLS001Topical Gel Compared to Vehicle in Subjects With Inflammatory Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: CLS001 Topical Gel|DRUG: CLS001 Topical Gel Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Corneal Neurotization as a Treatment for Neurotrophic Keratopathy
Status: TERMINATED
Conditions: Neurotrophic Corneal Ulcer|Neurotrophic Keratitis|Cranial Nerve V Diseases
Interventions: PROCEDURE: Corneal neurotization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Strategy to Prevent Hemorrhage Associated With Anticoagulation in Renal Disease Management (STOP HARM) Trial
Status: WITHDRAWN
Conditions: Chronic Kidney Disease|Acute Bleeding|Cerebrovascular Stroke
Interventions: DEVICE: Watchman|DRUG: Continued therapy with the prescribed oral anticoagulant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Safety and Efficacy Study of BCD-021 With Paclitaxel and Carboplatin Compared to Avastin With Paclitaxel and Carboplatin in Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Bevacizumab|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Long-term Efficacy and Safety of AXS-12 (Reboxetine) in Subjects With Narcolepsy
Status: ENROLLING_BY_INVITATION
Conditions: Narcolepsy|Cataplexy|Excessive Daytime Sleepiness
Interventions: DRUG: AXS-12 (reboxetine)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Immune Globulin (IVIG) to Prevent Neonatal Infection
Status: COMPLETED
Conditions: Infant, Newborn|Infant, Low Birth Weight|Infant, Small for Gestational Age|Infant, Premature|Sepsis
Interventions: DRUG: IVIG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of RC48-ADC in Local Advanced or Metastatic Gastric Cancer Subjects With the Overexpression of HER2
Status: COMPLETED
Conditions: Gastric Cancer|HER2 Overexpressing Gastric Carcinoma
Interventions: DRUG: RC48-ADC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Topiramate on Adolescent Alcohol Use: Efficacy and Mechanisms
Status: COMPLETED
Conditions: Alcohol Drinking
Interventions: DRUG: Topiramate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Roujin Formula in the Treatment of Fibromyalgia Syndrome With Blood Deficiency and Liver Depression
Status: COMPLETED
Conditions: Fibromyalgia Syndrome
Interventions: DRUG: Roujin Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Reslizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis (EGPA) Study
Status: UNKNOWN
Conditions: Asthma
Interventions: DRUG: Reslizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Electrochemotherapy for Colorectal Cancer - a Randomized Controlled Trial
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: PROCEDURE: Electrochemotheraoy|PROCEDURE: Electroporation with saline (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TC-A Registration Study
Status: COMPLETED
Conditions: Primary Osteoarthritis|Rheumatoid Arthritis|Post-traumatic Arthritis|Avascular Necrosis
Interventions: DEVICE: TC-A PS Total Knee Replacement System|DEVICE: TC-PLUS Solution PS Total Knee Replacement System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Clinical Evaluation of the Total Vascular Access (TVA) FLEX-1 Device Protocol FLEX-1-001
Status: COMPLETED
Conditions: Chronic Kidney Disease (CKD)
Interventions: DEVICE: Endovascular AVF (EndoAVF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventive Effects of Parecoxib on Postoperative Complications in Hepatocellular Carcinoma Patients Undergoing Hepatic Transcatheter Arterial Chemoembolization
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: parecoxib sodium
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Chlorthalidone and Hydrochlorothiazide Combined With Amiloride on Blood Pressure in Primary Hypertension.
Status: UNKNOWN
Conditions: Hypertension
Interventions: DRUG: Chlorthalidone 25 mg|DRUG: Hydrochlorothiazide 50 mg|DRUG: Amiloride 20 mg|DRUG: Amiloride 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Speech Function in Epileptic Patients Based on Stereoelectroencephalography Signal
Status: ACTIVE_NOT_RECRUITING
Conditions: Epilepsy
Interventions: BEHAVIORAL: Speech|DEVICE: Stereoelectroencephalography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparing a New Technique of Combining Carbon-dioxide With Electrocautery With Usual Technique of Stand-alone Electrocautery for Taking Down Left Internal Mammary Artery for Coronary Artery Bypass(CABG)
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Artery Disease With Myocardial Infarction
Interventions: PROCEDURE: Modified Carbo-dissection Technique|PROCEDURE: Conventional Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of the Human Acellular Vessel (HAV) With Fistulas as Conduits for Hemodialysis
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Failure|End Stage Renal Disease|Hemodialysis|Vascular Access
Interventions: BIOLOGICAL: Human Acellular Vessel (HAV)|PROCEDURE: Arteriovenous fistula (AVF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Treatment of Arterial Hypertension and Atrial Fibrillation
Status: COMPLETED
Conditions: Arterial Hypertension|Atrial Fibrillation
Interventions: PROCEDURE: Circumferential PV isolation|PROCEDURE: PV isolation+renal denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dopamine D2 and D3 Receptor Occupancy and Clinical Response in Older Patients With Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder
Interventions: DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of Chondroitin Sulfate on Structural Changes in Knee Osteoarthritis Patients Assessed by MRI
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: Chondroitin sulfate|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT