pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Ancillary Effects of Oral Naloxegol (Movantik)
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Naloxegol 25 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Mycophenolate Mofetil and Cyclophosphamide on the Lymphocyte Subsets in Patients With Proliferative Lupus Nephritis
Status: UNKNOWN
Conditions: Lupus Nephritis
Interventions: DRUG: MMF-MMF|DRUG: CTX-AZA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Ketogenic Diet on Lipoproteins in Refractory Epilepsy
Status: UNKNOWN
Conditions: Epilepsy|Cardiovascular Disease|Non-alcoholic Fatty Liver Disease|Quality of Life
Interventions: DIETARY_SUPPLEMENT: ketogenic diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: AMA1-C1/Alhydrogel + CpG 7909 for Malaria
Status: COMPLETED
Conditions: Plasmodium Falciparum Malaria
Interventions: BIOLOGICAL: AMA1-C1/Alhydrogel®|BIOLOGICAL: CPG 7909 Oligodeoxynucleotide (VaxImmune®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Pharmacokinetics and Safety of DBPR108 in Subjects With Renal Impairment
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: DBPR108 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Use of AZD6244 to Induce Increased ER Expression and Anti-Estrogen Response in ER-Negative/Low Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: AZ6244
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Safety, Tolerance and Pharmacokinetics of Phenlarmide Tablets
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Phenlarmide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Comparison of the Biolimus A9-eluting Stent With the Zotarolimus -Eluting Stent in Multi-vessel PCI
Status: COMPLETED
Conditions: Multivessel Coronary Artery Disease
Interventions: PROCEDURE: Percutaneous Coronary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Elastic Band Resistance Exercise on Glycated Haemoglobin and Muscle Strength, Balance, and Physical Function in Patients With Comorbid Type 2 Diabetes Mellitus and Knee Osteoarthritis
Status: COMPLETED
Conditions: Elastic Band Resistance Exercise With Comorbid Type 2 Diabetes Mellitus and Knee Osteoarthritis
Interventions: OTHER: Elastic Band Resistance Exercise|OTHER: active joint range-of-motion exercises and isometric contraction exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Quality of Recovery After Reversal With Neostigmine or Sugammadex.
Status: COMPLETED
Conditions: Incomplete Reversal of Neuromuscular Block
Interventions: DRUG: Sugammadex|DRUG: Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Transparent Safety Study of the 5 in 1 (DTwP-rHepB-Hib) Combination Vaccine Produced by the Indian Serine Institute in Children of Viet Nam Healthy From 6 to 12 Weeks of Age in a 3-dose Regimen, the Interval Between Doses is 4 Weeks
Status: COMPLETED
Conditions: Diphtheria|Tetanus|Pertussis|Hepatitis B|Haemophilus Influenzae Type B
Interventions: BIOLOGICAL: Study subjects will be vaccinated with 3 (three) vaccine doses. The first vaccine will be administered intramuscularly starting at 6-12 weeks of age followed by two doses at four-week interval
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Acoustic Enhancer Research on Laser Lithotripsy (AEROLITH)
Status: ACTIVE_NOT_RECRUITING
Conditions: Urinary Stones
Interventions: DEVICE: Ureteroscopy Laser Lithotripsy (URS-LL) with Acoustic Enhancer|DEVICE: Standard Ureteroscopic Laser Lithotripsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Dutogliptin/PHX1149T in Subjects With Type 2 Diabetes Mellitus on a Background Medication of Metformin
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: dutogliptin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety, Tolerability, and Efficacy of Tipifarnib Plus Bortezomib in the Treatment of Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Tipifarnib plus Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebral and Renal Oxymetry and Anesthetic Techniques in Newborns
Status: COMPLETED
Conditions: Cesarean Delivery Affecting Newborn
Interventions: DEVICE: Near infrared spectroscopy (spinal anesthesia)|DEVICE: Near infrared spectroscopy (general anesthesia)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Safety, Efficacy And Pharmacokinetics Study Of Tofacitinib In Pediatric Patients With sJIA
Status: COMPLETED
Conditions: Arthritis Juvenile Idiopathic
Interventions: DRUG: In open-label phase: treatment with tofacitinib|DRUG: In double-blind phase: treatment with tofacitinib or placebo in 1:1 ratio
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Oral Micronized Progesterone Shorten Time of Symptoms From Concussion
Status: COMPLETED
Conditions: Concussion
Interventions: DRUG: Progesterone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Control and Reducing the Risk of Hypoglycemic Episodes in Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DEVICE: Integrated Biobehavioral Monitoring & Feedback - 1 (IBMF-1)|DEVICE: Integrated Biobehavioral Monitoring & Feedback - 2 (IBMF-2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Cognitive Control of Negative Stimuli in BPD
Status: COMPLETED
Conditions: Borderline Personality Disorder
Interventions: DEVICE: transcranial DC stimulation : anodal|DEVICE: transcranial DC stimulation : sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Double Blinded Study Evaluating CACICOL20 Efficiency Versus Placebo Corneal Chronic Ulcers Healing
Status: COMPLETED
Conditions: Corneal Ulcer
Interventions: DEVICE: CACICOL20|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Augmentative and Alternative Communication (AAC) Intervention Delivered Via Hybrid Telehealth
Status: RECRUITING
Conditions: Intellectual Disability|Speech and Language Disorder
Interventions: BEHAVIORAL: Early Augmentative and Alternative Communication (AAC) Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: pBFS Guided rTMS Over DMPFC for Treatment-Resistant Depression
Status: RECRUITING
Conditions: Treatment Resistant Depression|Major Depressive Disorder
Interventions: DEVICE: active rTMS treatment|DEVICE: sham rTMS treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Computertomography Scan, Electrical Impedance Tomography, and Ultrasound of the Lung in Infants
Status: RECRUITING
Conditions: Infant ALL|Computed Tomography|Electric Impedance|Ultrasonography|Lung Injury
Interventions: OTHER: Electrical impedance tomography and ultrasonography of the lung
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: What is the Preferred Angle of Traction to Decompress Cervical Nerve Roots?
Status: UNKNOWN
Conditions: Cervical Radiculopathy
Interventions: OTHER: Cervical Traction from different angles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating a 13-Valent Pneumococcal Conjugate Vaccine in Healthy Infants
Status: COMPLETED
Conditions: Vaccines, Pneumococcal
Interventions: BIOLOGICAL: 13-valent pneumococcal conjugate vaccine|BIOLOGICAL: 7-valent pneumococcal conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Plastic Stent Within a Lumen-Apposing Stent for Malignant Biliary Obstruction
Status: COMPLETED
Conditions: Pancreatic Cancer|Endoscopy|Oncologic Disorders|Therapy Related Neoplasms
Interventions: DEVICE: Endoscopic biliary transmural drainage
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose-Dense MVAC With Pegfilgrastim Support in Subjects With Muscle-Invasive Urothelial Carcinoma
Status: COMPLETED
Conditions: Bladder Cancer|Muscle-invasive Bladder Cancer
Interventions: DRUG: Methotrexate|DRUG: Doxorubicin|DRUG: vinblastine|DRUG: cisplatin|DRUG: Pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression
Status: NOT_YET_RECRUITING
Conditions: Chronic Low Back Pain|Depression
Interventions: DRUG: Ketamine hydrochloride|BEHAVIORAL: Minimally Enhanced Usual Care|BEHAVIORAL: Brief narrative intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: PAIR (Paracetamol and Ibuprofen Research) Pilot Trial
Status: RECRUITING
Conditions: Patent Ductus Arteriosus
Interventions: DRUG: Paracetamol injection|DRUG: Ibuprofen injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cabozantinib and Pamiparib for the Treatment of Advanced of Refractory Solid Tumors
Status: RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Refractory Malignant Solid Neoplasm
Interventions: DRUG: Cabozantinib|DRUG: Pamiparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cytidine- and Creatine-Containing Drug in Treating Bipolar Depression
Status: WITHDRAWN
Conditions: Bipolar Depression
Interventions: DRUG: Valproate+Cytidine-+Creatine-|DRUG: Valproate+Cytidine-|DRUG: Valproate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brain Imaging Study of Acupuncture in Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain|Back Pain Lower Back Chronic|Low Back Pain, Recurrent
Interventions: PROCEDURE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: ORALIA Trial Medical Treatment vs Anoperineal Physiotherapy for Adult Anal Incontinence.
Status: TERMINATED
Conditions: Anal Incontinence
Interventions: BEHAVIORAL: standard medical treatment + anoperineal physiotherapy.|BEHAVIORAL: Standard medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Phase Ⅲ Trial of Adjuvant Chemotherapy in Patients With N2-3 Nasopharyngeal Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: CCRT+GP|DRUG: CCRT+PF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Safety of Iopamidol Versus Iodixanol During Coronary Angiography in Diabetic Patients
Status: TERMINATED
Conditions: Chronic Renal Impairment|Diabetes Mellitus
Interventions: DRUG: Iopamidol injection 76%|DRUG: iodixanol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Induction Chemotherapy, FOLFIRINOX Followed With Concurrent Capecitabine and Radiation Therapy in Inoperable Locally Advanced Cancer of the Pancreas
Status: UNKNOWN
Conditions: Cancer of Pancreas
Interventions: DRUG: FOLFIRINOX + CRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irinotecan and Docetaxel With or Without Cetuximab in Treating Patients With Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: docetaxel|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Bone Marrow Transplantation (BMT) and Renal Transplant for Multiple Myeloma (MM) With End Stage Renal Disease (ESRD)
Status: COMPLETED
Conditions: Multiple Myeloma|End Stage Renal Disease
Interventions: DRUG: Cyclophosphamide, anti-thymocyte globulin|PROCEDURE: Kidney transplant|RADIATION: Thymic irradiation|PROCEDURE: Bone marrow transplant from a related donor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medi-Port Pilot Randomized Controlled Trial
Status: COMPLETED
Conditions: Actively Undergoing Cancer Treatment|4-9 Years of Age|At Least 1 Month From Diagnosis|Able to Speak and Understand English|Presenting to Clinic for at Least a 2nd Subcutaneous Port Needle Insertion
Interventions: DEVICE: Medi-Port|DEVICE: Medi-Port
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ketogenic Diet Improves Thrombocytopenia in Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: Ketogenic Diet
Interventions: DIETARY_SUPPLEMENT: Strict ketogenic diet group|DIETARY_SUPPLEMENT: Cyclic ketogenic diet group|DIETARY_SUPPLEMENT: Autonomous ketogenesis group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Testing the Anesthetic Effectiveness of Three Different Dental Local Anesthetics Injected Next to a Lower First Molar
Status: COMPLETED
Conditions: Anesthetic Effectiveness
Interventions: PROCEDURE: Mandibular buccal Infiltration injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Vasovist Magnetic Resonance Angiography (MRA) in Peripheral Arterial Occlusive Disease
Status: TERMINATED
Conditions: Peripheral Arterial Occlusive Disease
Interventions: PROCEDURE: Diagnostic MR-Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Trial With Vinflunine in Patients With Metastatic Bladder Cancer and Impaired Renal Function
Status: COMPLETED
Conditions: Urothelial Carcinoma|Bladder Cancer|Renal Pelvis Cancer|Ureter Cancer|Urethra Cancer
Interventions: DRUG: Vinflunine|DRUG: Gemcitabine|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: mutant p53 peptide pulsed dendritic cell vaccine|BIOLOGICAL: tetanus toxoid helper peptide|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sacral Erector Spinae Plane Block on Hemorrhoid and Pilonidal Sinus Surgery
Status: COMPLETED
Conditions: Pain, Acute Post-Operative|Pilonidal Sinus|Hemorrhoids|Anesthesia
Interventions: PROCEDURE: sacral ESPB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fluorescence Spectroscopy for Gut Permeability Assessment
Status: UNKNOWN
Conditions: Development and Validation of Gut Permeability Sensor|Permeability; Increased|Celiac Disease|Inflammatory Bowel Diseases|Liver Diseases|HIV/AIDS
Interventions: DIAGNOSTIC_TEST: Spectroscopic gut permeability test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ecteinascidin 743 in Treating Patients With Advanced Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Endometrial Cancer|Gastrointestinal Stromal Tumor|Ovarian Cancer|Sarcoma|Small Intestine Cancer
Interventions: DRUG: trabectedin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Alendronate Sodium in Children With High-Turnover Idiopathic Juvenile Osteoporosis
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Alendronate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project BELONG: Breaking the Cycle of Intergenerational Family Violence and Trauma
Status: WITHDRAWN
Conditions: Mother-child Relations|Parenting|Parent Child Abuse|Family Conflict|Parental Stress|Family Relations|Childhood Disorder of Social Functioning, Unspecified
Interventions: OTHER: Therapeutic intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Randomised Controlled Trial of Home-based Exercise Intervention for Caregivers of Persons With Dementia
Status: UNKNOWN
Conditions: Depression
Interventions: OTHER: 12-step sitting Tai Chi Chuan|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of WB-EMS and Dietetic Treatment on Cancer Patients
Status: COMPLETED
Conditions: Cancer|Cancer Cachexia|Weight Loss|Muscle Loss|Muscle Weakness
Interventions: OTHER: Whole-Body Electromyostimulation (WB-EMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of Ezetimibe (MK-0653) on the Postprandial (Following a Meal) Lipoprotein Response in Participants With Primary Hypercholesterolemia (High Cholesterol) (MK-0653-072)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: ezetimibe|DRUG: Comparator: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Coordinating Center: Natural History of Barrett's Esophagus Using Tethered Capsule Endomicroscopy
Status: ACTIVE_NOT_RECRUITING
Conditions: Barrett Esophagus
Interventions: DEVICE: Tethered Capsule Endomicroscopy (TCE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: S1313, PEGPH20 in Treating Patients With Newly Diagnosed Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: PEGPH20|DRUG: Oxaliplatin|DRUG: Leucovorin|DRUG: Irinotecan|DRUG: 5-fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of SYNB1934 in Patients With PKU (SYNPHENY-3)
Status: TERMINATED
Conditions: Phenylketonuria
Interventions: DRUG: SYNB1934v1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evidence-based Evaluation and Mechanism of Shenhuang Granules in the Treatment of Sepsis
Status: NOT_YET_RECRUITING
Conditions: Sepsis
Interventions: DRUG: shenhuang granule|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of a Community Based Engagement Program Focused on Adolescents With Epilepsy
Status: NOT_YET_RECRUITING
Conditions: Epilepsy
Interventions: OTHER: Community Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: IN10018 Combination Therapy in Previously-treated Locally Advanced or Metastatic Solid Tumor Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced or Metastatic Solid Tumors
Interventions: DRUG: IN10018+PLD|DRUG: IN10018+PLD+Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter In-class Transition Study of Ixazomib Combined With Pomalidomide and Dexamethasone or With Lenalidomide and Dexamethasone in Adults With Relapsed/Refractory Multiple Myeloma
Status: WITHDRAWN
Conditions: Multiple Myeloma
Interventions: DRUG: Ixazomib|DRUG: Pomalidomide|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantitation of Cardiac Output Change by Impedance Cardiography in Subjects Undergoing Exercise Gated Stress/Rest Tc-99m CZT-SPECT MPI
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: Single photon emission computed tomography myocardial perfusion imaging|OTHER: exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Celecoxib and Radiation Therapy in Treating Patients With Locally Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: celecoxib|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SMP-986 Phase 2 Proof of Concept in Patients With Overactive Bladder Syndrome (OABS)
Status: COMPLETED
Conditions: Overactive Bladder Syndrome (OABS)
Interventions: DRUG: Placebo|DRUG: Placebo|DRUG: SMP-986
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Liposome Entrapped Paclitaxel Easy to Use (LEP-ETU) and Taxol® Pharmacokinetics in Patients With Advanced Cancer
Status: COMPLETED
Conditions: Neoplasm
Interventions: DRUG: Liposome Entrapped Paclitaxel Easy to Use (LEP-ETU)|DRUG: Paclitaxel for injection (Taxol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Montelukast (MK-0476) Compared With Fluticasone in Pediatric Participants With Chronic Asthma (MK-0476-303)
Status: WITHDRAWN
Conditions: Asthma, Bronchial
Interventions: DRUG: Montelukast sodium|DRUG: Placebo to montelukast|DRUG: Fluticasone propionate|DRUG: Placebo to fluticasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Food Cravings Strategies During Dietary Weight Loss
Status: RECRUITING
Conditions: Obesity|Food Cravings|Weight Loss
Interventions: BEHAVIORAL: Test two food cravings strategies during dietary weight loss|BEHAVIORAL: Dietary weight loss program +Food cravings strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Adverse Events and How Intravenously (IV) Infused Telisotuzumab Vedotin (ABBV-399) Moves Through the Body as a Monotherapy in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
Status: NOT_YET_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Telisotuzumab Vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spironolactone Safety in African Americans With Mild Cognitive Impairment and Early Alzheimer's Disease
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Alzheimer Disease
Interventions: DRUG: Spironolactone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Low-dose Ketamine vs Morphine for Vaso-occlusive Crisis in Sicklers
Status: COMPLETED
Conditions: Sickle Cell Crisis|Acute Pain
Interventions: DRUG: Low dose ketamine|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of GlaxoSmithKline Biologicals' HPV Vaccine 580299 (Cervarix) in HIV Infected Females
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: BIOLOGICAL: Cervarix|BIOLOGICAL: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Study of Two Different Techniques to Perform TAP-blocks
Status: COMPLETED
Conditions: POSTOPERATIVE PAIN
Interventions: PROCEDURE: Surgical TAP block|PROCEDURE: Conventional TAP block|DRUG: 0.5% ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Feasibility, Safety and Efficacy of Psychotherapy Assisted Psilocybin for Treatment of Severe OCD
Status: NOT_YET_RECRUITING
Conditions: Obsessive-compulsive Disorder
Interventions: COMBINATION_PRODUCT: psychotherapy assisted psilocybin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Exercise for Overweight Women With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Obesity
Interventions: OTHER: 16-week exercise training program|OTHER: Control Group without PCOS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bone Microarchitectural Database Constitution From HR-pQCT Device in Clinical Situation Potentially Associated With Bone Loss
Status: TERMINATED
Conditions: Osteoporosis|Bone Loss
Interventions: DEVICE: HR-pQCT|DEVICE: DEXA|DEVICE: pQCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: SimpleC Wellness Platform With Social Robot Interaction
Status: COMPLETED
Conditions: Engagement, Patient|Mood|Quality of Life|Aging|Mild Cognitive Impairment|Cognitive Impairment|Dementia
Interventions: OTHER: SimpleC Wellness Platform with Social Robot Interaction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Adjuvant Chemotherapy With S-1 Plus Oxaliplatin Versus S-1 Alone in Locally Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: Oxaliplatin plus S-1|DRUG: S-1 only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgery Plus Single Agent Chemotherapy Versus Primary Chemotherapy for Gestational Trophoblastic Neoplasms
Status: UNKNOWN
Conditions: Gestational Trophoblastic Neoplasms
Interventions: PROCEDURE: Total abdominal hysterectomy and methotrexate|DRUG: Methotrexate plus folinic acid alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improvement of Lower Digestive Endoscopy Without Anesthesia : Evaluation of the Virtual Reality Mask
Status: NOT_YET_RECRUITING
Conditions: Digestive System Disease
Interventions: DEVICE: Use of a VR mask|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Seeded Cells on Matrix Plug Treating Crohn's Perianal Fistulas (STOMP-II)
Status: ACTIVE_NOT_RECRUITING
Conditions: Perianal Fistula|Crohn's Disease
Interventions: PROCEDURE: Seton Placement|DRUG: AVB-114
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Non-significant Risk Clinical Study of Therapeutic Ultrasound for Patients With Diabetic Foot Ulcers.
Status: COMPLETED
Conditions: Diabetic Foot Ulcer|Peripheral Arterial Disease|Wound; Foot
Interventions: DEVICE: VibratoSleeve Therapeutic Ultrasound Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Garlic in Patients With Febrile Neutropenia
Status: UNKNOWN
Conditions: Chemotherapy|Neutropenia
Interventions: DIETARY_SUPPLEMENT: Solgar Israel|OTHER: Placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Post-prandial Lipid Effects of Raltegravir (RAL) vs Ritonavir -Boosted Darunavir (DRV-r) in Anti-retroviral Therapy (ART)- Naive Adults or Adults Recommencing ART.
Status: COMPLETED
Conditions: HIV|Cardiovascular Disease
Interventions: DRUG: raltegravir plus truvada|DRUG: Darunavir, ritonavir, tenofovir/emtricitabine (Truvada)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Phase II Study of INC424 Patients With Primary Myelofibrosis (PMF) or Post Polycythaemia Myelofibrosis (PPV MF) or Post Essential Thrombocythaemia Myelofibrosis (PET-MF)
Status: COMPLETED
Conditions: Primary Myelofibrosis (PMF)|Post Polycythaemia Myelofibrosis (PPV MF)|Post Essential Thrombocythaemia Myelofibrosis (PET-MF)
Interventions: DRUG: INC424
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apixaban for PrOphyLaxis of thromboemboLic Outcomes in COVID-19
Status: TERMINATED
Conditions: Covid19|Thrombosis
Interventions: DRUG: Apixaban 2.5 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fornix and NbM as Targets of Stimulation In Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: DEVICE: DBS of the fornix, power on|DEVICE: DBS of the NbM, power on|DEVICE: DBS of the fornix, power off|DEVICE: DBS of the NbM, power off
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liver Enzyme Abnormalities and Risk Factors in Taking Herbal Medicine
Status: COMPLETED
Conditions: Drug-Induced Liver Injury|Musculoskeletal Diseases
Interventions: DRUG: Herbal medicine|PROCEDURE: Acupuncture|PROCEDURE: Pharmacopuncture|PROCEDURE: Bee venom pharmacopuncture|PROCEDURE: Chuna manipulation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preoperative Radiotherapy for Sarcomas of the Extremities With Intensity-Modulation, Image-Guidance and Small Safety-margins
Status: UNKNOWN
Conditions: Soft Tissue Sarcoma of the Limb|AJCC Stage II and III
Interventions: RADIATION: IMRT/IGRT, Tumor resection, Brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral vs. Interpersonal Therapy (IPT) Prevention of Depression in Adolescents
Status: COMPLETED
Conditions: Depressive Symptoms
Interventions: BEHAVIORAL: Cognitive-behavioral|BEHAVIORAL: Interpersonal Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective Cohort Study On Change of Cognitive Function In Aged-related Hearing Loss With Hearing Aids
Status: RECRUITING
Conditions: Age-related Hearing Loss|Hearing Loss, Sensorineural|Hearing Aid|Cognitive Function Abnormal
Interventions: DEVICE: Hearing Aids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Building Engagement Using Financial Incentives Trial - Hypertension
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension|Health Behavior|Healthcare Patient Acceptance|Patient Engagement|Adherence, Patient
Interventions: BEHAVIORAL: Remote Patient Monitoring|BEHAVIORAL: Self-monitoring of hypertension-related factors|BEHAVIORAL: Immediate financial incentives|BEHAVIORAL: Delayed financial incentives
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Systematic Review: Retigabine for Adjunctive Therapy in Partial Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: retigabine/ezogabine|DRUG: lacosamide|DRUG: zonisamide|DRUG: pregabalin|DRUG: eslicarbazepine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Quality of Vision and Visual Outcomes With Bilateral Implantation of the Clareon PanOptix Intraocular Lens
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: The Clareon™ PanOptix™ Trifocal (toric and non-toric models)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Vestibular Training on Postural Control of Healthy Adults Using Virtual Reality
Status: RECRUITING
Conditions: Virtual Reality|Vestibular Training|Balance Assessment
Interventions: DEVICE: Vestibular training using VR followed by Control|DEVICE: Control followed by Vestibular training using VR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Erlotinib vs. Standard Chemotherapy in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) and Eastern Cooperative Oncology Group (ECOG)Performance Status (PS) 2
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Tarceva (Trademark) (erlotinib HCl, OSI-774)|DRUG: Combination carboplatin and paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Corneal Aberrations and Visual Outcomes in Patients Implanted With an AcrySof Toric Intraocular Lens (IOL)
Status: WITHDRAWN
Conditions: Cataracts|Astigmatism
Interventions: DEVICE: Toric
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nafamostat Mesilate in the Treatment of Severe Infection-associated Coagulopathy
Status: NOT_YET_RECRUITING
Conditions: Sepsis|Sepsis-induced Coagulopathy|Nafamostat Mesilate
Interventions: DRUG: Nafamostat mesilate|DRUG: 5% glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Caffeine on Physical Performance of Ice Hockey Players
Status: COMPLETED
Conditions: Caffeine|Athletic Performance
Interventions: DIETARY_SUPPLEMENT: Caffeine|DIETARY_SUPPLEMENT: Placebo drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Cisplatin, Gemcitabine, Sunitinib Malate + Radical Cystectomy for TCC
Status: TERMINATED
Conditions: Transitional Cell Carcinoma of the Bladder
Interventions: DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Sunitinib Malate|PROCEDURE: Radical Cystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Of Oral Melatonin To Prevent Necrotizing Enterocolitis
Status: COMPLETED
Conditions: Necrotizing Enterocolitis
Interventions: DRUG: Melatonin 6 MG|OTHER: Breast Milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Terlipressin in Septic Shock: Effects on Microcirculation
Status: COMPLETED
Conditions: Septic Shock|Sepsis
Interventions: DRUG: continuous infusion of terlipressin|DRUG: Arginine vasopressin|DRUG: terlipressin bolus administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Amniotic Fluid Tandem Mass Spectrometry for Pregnancies Complicated by NIH and Severe Symmetrical IUGR
Status: TERMINATED
Conditions: Hydrops Fetalis|Fetal Growth Retardation
Interventions: PROCEDURE: Tandem MS test for inborn errors of metabolism
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Detecting the Influence of Cataract Surgery on the Development of Diabetic Retinopathy in Patients With Diabetes Mellitus Type 2 With and Without Diabetic Retinopathy Using OCT Angiography
Status: UNKNOWN
Conditions: Diabetic Retinopathy
Interventions: DEVICE: Phacoemulsification
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Romiplostim Versus Eltrombopag in the Treatment of Thrombocytopenia in Patients With Wiskott-Aldrich Syndrome
Status: UNKNOWN
Conditions: Wiskott-Aldrich Syndrome
Interventions: DRUG: Romiplostim|DRUG: Eltrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Pegylated Interferon (PEG-IFN) Alfa-2a (Pegasys) in Participants With Chronic Hepatitis D (CHD)
Status: COMPLETED
Conditions: Hepatitis D, Chronic
Interventions: DRUG: Pegylated Interferon (PEG-IFN) alfa-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnesium and Vitamin D Combination for Post-COVID Syndrome
Status: COMPLETED
Conditions: Post-COVID-19 Syndrome|Long COVID|Vitamin D Deficiency|Magnesium Deficiency
Interventions: DIETARY_SUPPLEMENT: Magnesium chloride|DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: Inert placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Establishing a New Ultrasound Technique to Improve Assessment of Chronic Kidney Disease.
Status: NOT_YET_RECRUITING
Conditions: Chronic Kidney Diseases
Interventions: DIAGNOSTIC_TEST: Contrast enhanced ultrasound scan|DIAGNOSTIC_TEST: MRI scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Single and Multiple Ascending Dose, First-in- Human Study in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: TD-5202|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Modafinil as an Adjunctive on Cognitive Functioning in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia and Schizophrenia Spectrum Psychosis
Interventions: DRUG: modafinil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intervention Effect of Canagliflozin on Prediabetes in Patients With HIV.
Status: RECRUITING
Conditions: PreDiabetes|Hiv
Interventions: DRUG: Canagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relation of Laboratory Indices to Left Ventricular Thrombus Formation in Patients With Acute Anterior ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention or Thrombolytic Therapy
Status: NOT_YET_RECRUITING
Conditions: Left Ventricular Thrombus
Interventions: OTHER: Primary percutaneous coronary intervention or thrombolytic therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial To Determine The Effectiveness And Safety Of Topical Insulin In Dry Eye
Status: RECRUITING
Conditions: Dry Eye|Insulin
Interventions: DRUG: Insulin|DRUG: Cyclosporins|DRUG: Artificial tears
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Imaging in Demyelinating Diseases
Status: ENROLLING_BY_INVITATION
Conditions: Multiple Sclerosis|Inflammatory Demyelinating Disease
Interventions: DRUG: C-11 ER176 Radiotracer|DRUG: C11 Pittsburgh Compound B|DIAGNOSTIC_TEST: PET/CT scan|DIAGNOSTIC_TEST: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessment of the Clinical and Ultrasound Response to Apremilast by Clinical Evaluation and by a Joint-periarticular-nail Ultrasound Index in Patients With Active Psoriatic Arthritis
Status: UNKNOWN
Conditions: Arthritis; Psoriasis (Etiology)
Interventions: DRUG: Apremilast
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Persistence of Immunity Against Hepatitis B in 12-13 Year Old Adolescents After Infant Hepatitis B Vaccination
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Engerix™-B Kinder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Avastin (Bevacizumab) And Fotemustine in Patients With Recurrent Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: bevacizumab [Avastin]|DRUG: fotemustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Estimate the Effect of Multiple Dose Abrocitinib on Caffeine, Efavirenz, and Omeprazole in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Abrocitinib|DRUG: Omeprazole|DRUG: Caffeine|DRUG: Efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Post-Market Evaluation of the Rotation Medical Rotator Cuff System
Status: COMPLETED
Conditions: Partial Thickness Supraspinatus Tendon Tear|Full Thickness Supraspinatus Tendon Tear
Interventions: DEVICE: Bioinductive implant|DEVICE: Surgical repair
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography in Predicting Response in Patients Who Are Undergoing Treatment With Pemetrexed Disodium and Cisplatin With or Without Surgery for Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: pemetrexed disodium|PROCEDURE: adjuvant therapy|PROCEDURE: therapeutic conventional surgery|RADIATION: fludeoxyglucose F 18
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Fat Grafts Supplemented With Adipose-derived Regenerative Cells
Status: COMPLETED
Conditions: Craniofacial Microsomia
Interventions: PROCEDURE: Supplementation of ADRC|PROCEDURE: Without supplementation of ADRC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT