pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest
Status: RECRUITING
Conditions: Hypoxia-Ischemia, Brain|Heart Arrest|Status Epilepticus|Refractory Status Epilepticus|Seizures|Anoxic-Ischemic Encephalopathy|Anoxia-Ischemia, Cerebral
Interventions: DRUG: Burst Suppression EEG Target Intravenous Anesthesia|DRUG: Seizure Suppression EEG Target Intravenous Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Intra Canal Medications on Postoperative Flare-up in Endodontic Re-treatment Cases
Status: UNKNOWN
Conditions: Postoperative Pain|Pain, Dental
Interventions: COMBINATION_PRODUCT: calcium hydroxide chlorhexidine combination|OTHER: calcium hydroxide intra-canal medicament
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in the Retinal and Carotid Microcirculation After Restoring Normoglycemia in Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus|Microangiopathy|Diabetic Retinopathy|Arteriosclerosis|Carotid Atherosclerosis
Interventions: DRUG: Antidiabetic treatment by usual care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Safety, Tolerability and Immunogenicity of COVID-19 Vaccine (SCTV01C) in Healthy, Unvaccinated Adults
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: SCTV01C|OTHER: Adjuvant|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Reducing Treatment Risk in Older Adults With Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 2 Diabetes Treated With Insulin|Hypoglycemia|Primary Health Care|Polypharmacy
Interventions: BEHAVIORAL: Conversation Aid|OTHER: Attention Control Educational Handout
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Nesiritide Infusion for the Treatment of Decompensated Heart Failure and Renal Dysfunction
Status: COMPLETED
Conditions: Congestive Heart Failure|Renal Insufficiency
Interventions: DRUG: Nesiritide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BFR Training on a Bike to Augment RC Strength, Leg Strength, and VO2 Peak
Status: UNKNOWN
Conditions: Can BFR Cycling Augment Strength and VO2peak
Interventions: OTHER: BFR cycling|OTHER: Cycling without BFR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Health Behavior-Related Outcomes With Diaphragmatic Breathing Retraining in Heart Failure Patients
Status: WITHDRAWN
Conditions: Chronic Heart Failure
Interventions: BEHAVIORAL: Diaphragmatic Breathing Retraining
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Trial to Evaluate the Efficacy, Safety & Tolerability of Brexpiprazole in the Maintenance Treatment of Adults With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Brexpiprazole|DRUG: Antidepressant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of HIV and STDs in Drug Using Women
Status: COMPLETED
Conditions: HIV|Sexually Transmitted Diseases|Substance Abuse
Interventions: BEHAVIORAL: NIDA Cooperative Agreement Standard Intervention plus HIV/STD testing|BEHAVIORAL: Standard Intervention plus Well-Woman Exam|BEHAVIORAL: Standard Intervention plus Well-Woman Exam and Peer-Delivered Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: PREVENTION
Clinical trial: IMPT Dose Escalation for NSCLC (HyDose)
Status: NOT_YET_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: RADIATION: Standard-dose intensity-modulated proton therapy (IMPT-60)|RADIATION: Dose-escalated intensity-modulated proton therapy (IMPT-74)|DRUG: Cisplatin or carboplatin + pemetrexed for induction chemotherapy, cisplatin + docetaxel for concurrent chemotherapy|DRUG: Immunotherapy: adjuvant durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coronary Angiography in Critically Ill Patients With Type II Myocardial Infarction
Status: WITHDRAWN
Conditions: Type 2 Myocardial Infarction|Coronary Artery Disease|Percutaneous Coronary Intervention|Critical Illness
Interventions: PROCEDURE: percutaneous coronary intervention (stenting)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid in Pediatric Scoliosis Surgery
Status: RECRUITING
Conditions: Scoliosis
Interventions: DRUG: Tranexamic acid|DRUG: Tranexamic acid infusion under ROTEM-guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: OVT for Epicondylosis (Tennis Elbow)
Status: COMPLETED
Conditions: Epicondylitis, Lateral|Tendinopathy, Elbow
Interventions: DEVICE: OrthoVisc®-T (OVT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COMpassion FOcused Therapy and Breathing Pattern REtraining After Cancer Recurrence
Status: UNKNOWN
Conditions: Psychological Distress|Cancer Recurrence
Interventions: BEHAVIORAL: Compassion Focused Therapy (CFT) combined with Breathing Pattern Retraining (BPR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Air Polishing as an Adjunct in Non-surgical Periodontal Therapy
Status: UNKNOWN
Conditions: Periodontitis
Interventions: DEVICE: Ultrasonic scaler and Gracey currettes|DEVICE: Air polishing with erythritol powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Azilect® (Rasagiline) in Levodopa-treated Parkinson's Disease Patients With Motor Fluctuations in Korea
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Placebo|DRUG: Azilect®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Erythropoietin on Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome
Status: RECRUITING
Conditions: Acute Respiratory Distress Syndrome
Interventions: DRUG: Human erythropoietin injection|DRUG: 0.9%NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of VIB4920 in Participants With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: VIB4920|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Nivolumab Verses Nivolumab and Ipilimumab Combination in EGFR Mutant Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Ipilimumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors
Status: RECRUITING
Conditions: HER2-positive Advanced Solid Tumor
Interventions: BIOLOGICAL: DB-1303/BNT323|DRUG: Pertuzumab Injection|DRUG: Ritonavir|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeting Pancreatic Cancer With Sodium Glucose Transporter 2 (SGLT2) Inhibition
Status: COMPLETED
Conditions: Pancreas Cancer|Pancreatic Cancer|Cancer of the Pancreas
Interventions: DRUG: Dapagliflozin|DEVICE: BIOSENSE meters
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of 2 Doses of PRAX-944 in Participants With Essential Tremor
Status: COMPLETED
Conditions: Essential Tremor
Interventions: DRUG: 100 mg PRAX-944|DRUG: 60 mg PRAX-944|DRUG: Placebo|DRUG: Flexibly dosed 20 mg to 100 mg PRAX-944
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-center, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Certolizumab Pegol in Combination With Methotrexate in the Treatment of Disease Modifying Antirheumatic Drugs (DMARD)-naïve Adults With Early Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Certolizumab Pegol|OTHER: Placebo|BIOLOGICAL: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Santyl Applications to Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot Ulcers|Diabetic Foot Wounds
Interventions: BIOLOGICAL: Collagenase SANTYL® Ointment|BIOLOGICAL: Hydrogel (if needed) and foam dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Target Attainment of Continuous Infusion Flucloxacillin and Cefazolin Coupled With TDM vs. Standard of Care Treatment in Patients With Complicated S. Aureus Infection
Status: RECRUITING
Conditions: Complicated Staphylococcus Aureus (S. Aureus) Infections (CSAI)
Interventions: DRUG: FLU or CZO as continuous infusion|DRUG: standard FLU or CZO intermittent bolus administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability, Food Effect and Safety, Tolerability of a New Oral Suspension in Comparison to the Marketed Moxifloxacin Tablet in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Moxifloxacin (Avelox, BAY12-8039)|DRUG: Moxifloxacin (BAY12-8039)|DRUG: Moxifloxacin (BAY12-8039)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Oropharyngeal Colostrum for Immune Stimulation in Very Low Birth Weight Infants
Status: COMPLETED
Conditions: Very Low Birth Weight Infants
Interventions: OTHER: application of mother's own colostrum|OTHER: application of sterile water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Hypofractionated Adaptive Image-Guided Radiation Therapy for Localized Adenocarcinoma of the Prostate
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: hypofractionation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Evaluating Ambulatory Treatment of Travelers' Diarrhea
Status: TERMINATED
Conditions: Acute Watery Diarrhea|Dysentery/Febrile Diarrhea
Interventions: DRUG: Single dose rifaximin 1650 mg|DRUG: Single dose azithromycin 500 mg|DRUG: Single dose levofloxacin 500 mg|DRUG: Single dose azithromycin 1000 mg plus loperamide|DRUG: Single dose azithromycin 1000 mg plus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The RIPPLE AT-PLUS Study
Status: NOT_YET_RECRUITING
Conditions: Atrial Tachycardia
Interventions: PROCEDURE: Catheter ablation of atrial tachycardia: Ripple Mapping guided.|PROCEDURE: Catheter ablation of atrial tachycardia: Conventional mapping guided.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Dose Study to Investigate the Pharmacokinetics of MK-0941 in Participants With Renal Insufficiency (MK-0941-015-02)
Status: TERMINATED
Conditions: Type 2 Diabetes
Interventions: DRUG: MK-0941 20 mg|DRUG: MK-0941 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PROCLAIM-CX-072: A Trial to Find Safe and Active Doses of an Investigational Drug CX-072 for Patients With Solid Tumors or Lymphomas
Status: COMPLETED
Conditions: Solid Tumor|Lymphoma
Interventions: DRUG: CX-072|DRUG: ipilimumab|DRUG: vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Effectiveness and Safety of Fremanezumab on Participants With Fibromyalgia
Status: TERMINATED
Conditions: Fibromyalgia
Interventions: DRUG: Fremanezumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Efficacy and Safety of Rengalin in the Treatment of Cough in Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Rengalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Diazepam Buccal Film Administered in the Interictal and in the Ictal-Periictal States to Adults With Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Diazepam Buccal Film 12.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrating Veteran-Centered Care for Advanced Liver Disease (I-VCALD)
Status: NOT_YET_RECRUITING
Conditions: Liver Diseases
Interventions: OTHER: I-VCALD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Tea Extract, Blood Lipid and Dietary Fat
Status: COMPLETED
Conditions: Lipid Metabolism|Diabetes
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Tea beverage|DIETARY_SUPPLEMENT: Tea extract (medium concentration)|DIETARY_SUPPLEMENT: Tea extract (high concentration)|OTHER: High fat liquid meal challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Cannabinoids in Amyotrophic Lateral Sclerosis or Motor Neurone Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis|Motor Neuron Disease
Interventions: DRUG: MediCabilis CBD Oil|DRUG: Placebo Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Natural Vitamin E Tocotrienol on the Treatment of Surgical Scars
Status: TERMINATED
Conditions: Scar
Interventions: DIETARY_SUPPLEMENT: Natural Vitamin E Tocotrienol supplement (TCT)|DEVICE: Natural Vitamin E Tocotrienol Cream (TCT)|OTHER: Placebo|OTHER: Placebo Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Evaluate the Safety, Efficacy, and Pharmacokinetics of CRN04894 in Participants With Congenital Adrenal Hyperplasia (TouCAHn)
Status: RECRUITING
Conditions: Congenital Adrenal Hyperplasia|Classic Congenital Adrenal Hyperplasia
Interventions: DRUG: CRN04894
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebral Substrates of Prospective Memory in Young and Its Disruption in Normal Aging and in Alzheimer's Disease: A Study in Anatomical MRI, Diffusion Tensor MRI and Functional MRI
Status: UNKNOWN
Conditions: Alzheimer's Disease
Interventions: DEVICE: functional brain MRI|OTHER: Neuropsychology tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lidocaine and Analgesia After Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Postoperative Pain|Opioid Consumption
Interventions: DRUG: Lidocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Epidiolex in Patients With Electrical Status Epilepticus of Sleep (ESES).
Status: RECRUITING
Conditions: Electrical Status Epilepticus of Slow-Wave Sleep
Interventions: DRUG: Epidiolex 100 mg/mL Oral Solution|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Lidocaine Inhalation and Intravenous Dexamethasone in Reducing Pain After Laryngeal Mask Insertion
Status: COMPLETED
Conditions: Adult Patients Undergoing Elective Surgery With General Anesthesia and LMA Insertion
Interventions: DRUG: lidocaine inhalation; intravenous dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacodynamics of AZR-MD-001 in Contact Lens Discomfort (CLD)
Status: COMPLETED
Conditions: Contact Lens Discomfort
Interventions: DRUG: AZR-MD-001 ointment/semi-solid drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Restenosis in Coronary Stents And Cutaneous HEaLing
Status: UNKNOWN
Conditions: Coronary Restenosis|Coronary Stent Occlusion|Skin Scarring|Keloid
Interventions: DIAGNOSTIC_TEST: Skin biopsy and blood sample for inflammation markers, RNA and proteins
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Therapy of Bronchoalveolar Lavage and Local Amikacin Injection in Patients With Acute Exacerbation of Bronchiectasis
Status: UNKNOWN
Conditions: Bronchiectasis
Interventions: DRUG: Bronchoalveolar Lavage and Local Amikacin Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Premature Newborns Treated With Less Invasive Surfactant Administration Under Heated Humidified High-flow
Status: COMPLETED
Conditions: Respiratory Disease|Newborn Rds
Interventions: DEVICE: Nazal CPAP|DEVICE: Heated humidified high-flow air support with nasal cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenomics on Individualized Precise Treatment of Patients With Depression
Status: NOT_YET_RECRUITING
Conditions: Pharmacogenomics|Depression
Interventions: DIAGNOSTIC_TEST: Genomic analysis of antidepressants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: CI(R)CA : Coumadin Interaction With Rofecoxib, Celecoxib and Acetaminophen
Status: COMPLETED
Conditions: Antiphospholipid Antibody Syndrome
Interventions: DRUG: Celecoxib|DRUG: Acetaminophen|DRUG: Rofecoxib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Pressure Injury Occurrence in Patients Using Two Different Mattresses
Status: COMPLETED
Conditions: Pressure Injury|Sleep|Pain|Satisfaction, Patient|Noise Exposure|Strains|Satisfaction, Personal
Interventions: DEVICE: Intervention mattress
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluating Long-term Use of a Pediatric Robotic Exoskeleton (P.REX/Agilik) to Improve Gait in Children With Movement Disorders
Status: RECRUITING
Conditions: Cerebral Palsy|Muscular Dystrophy|Spina Bifida|Incomplete Spinal Cord Injury
Interventions: DEVICE: EA-KAFO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Serratus Intercostal Plane Block,New Analgesia in Supraumbilical Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Analgesia|Local Anaesthetic|Abdominal Injury
Interventions: PROCEDURE: fascial block as postoperative analgesia|DRUG: Morphine|DEVICE: PCA CADD Smith Medical pumps
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: GENSARC 2008 : Medical Economic Evaluation of the Molecular Detection by FISH (Fluorescent in Situ Hybridization) and by PCR (Polymerase Chain Reaction) of Sarcomas Specific Translocations and Amplifications .
Status: COMPLETED
Conditions: Sarcoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PerClot Compared to Usual Care in Gynaecology Procedures
Status: COMPLETED
Conditions: Endometriosis|Ovarian Cyst|Menorrhagia|Cancer|Uterine Fibroids
Interventions: DEVICE: PerClot|DEVICE: Floseal, Surgicel, Surgiflo, Arista|PROCEDURE: Electrocautery/Diatermy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AP-L1898 Capsule in Patients With Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: JS111(AP-L1898 Capsules)|DRUG: JS111(AP-L1898 Capsules)|DRUG: JS111(AP-L1898 Capsules)|DRUG: JS111(AP-L1898 Capsules)|DRUG: JS111(AP-L1898 Capsules)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of i-Scan for Detecting Reflux Esophagitis
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease|Reflux Esophagitis
Interventions: DEVICE: i-scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Altrazeal Range of Motion Study Comparing With Typical Carboxymethyl
Status: TERMINATED
Conditions: Burn
Interventions: DEVICE: Aquacel AG, typical carboxymethylcellulose dressing|DEVICE: Altrazeal Flexible Hydrogel Nanoparticle Wound Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ipilimumab and Nivolumab Followed by Adjuvant Nivolumab in Locally Advanced or Limited Metastatic Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurovascular Embolization Cover for Treatment of Intracranial Aneurysms and Carotid/Vertebrobasilar Fistulae
Status: UNKNOWN
Conditions: Intracranial Aneurysms|Cavernous Carotid Fistula|Vertebrobasilar Fistula
Interventions: DEVICE: NEC - Neurovascular Embolization Cover
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Safety, Tolerability, and Pharmacokinetics of AZD7503 in Participants With Suspected NASH.
Status: TERMINATED
Conditions: Steatohepatitis
Interventions: DRUG: AZD7503
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Orthotics and Parkinson's Disease: The Acute and Long-term Effects of Increased Somatosensory Feedback
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: DEVICE: Orthotics alone|DEVICE: Orthotics+textured top cover
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Multipoint Pacing CRT-D on Neurohormonal Activation.
Status: COMPLETED
Conditions: Heart Failure
Interventions: DEVICE: Cardiac Resynchronization Therapy with MultiPoint Pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TCA Peel and Photobiomodulation for Hand Rejuvenation
Status: UNKNOWN
Conditions: Skin Aging
Interventions: COMBINATION_PRODUCT: 20% TCM and PBM|OTHER: 20% TCM and PBM placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Whey or Casein - Liver Fat Reduction and Metabolic Improvement by Fast vs. Slow Proteins
Status: RECRUITING
Conditions: Type2 Diabetes|NAFLD
Interventions: DIETARY_SUPPLEMENT: protein supplement|DIETARY_SUPPLEMENT: placebo supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Histological Prediction and Choice of the Resection Strategy in Front of a Colorectal Lesion > 2 cm: Prospective Comparison of Endoscopic Characterization, Non-targeted and Targeted Biopsies
Status: COMPLETED
Conditions: Endoscopic Submucosal Dissection
Interventions: PROCEDURE: Endoscopic Submucosal Dissection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Continued Access to PREVAIL (CAP2) - WATCHMAN Left Atrial Appendage (LAA) Closure Technology
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: WATCHMAN LAA Closure Technology
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Characterize Subcutaneous or Intravenous Alemtuzumab in Patients With Progressive Multiple Sclerosis
Status: COMPLETED
Conditions: Progressive Multiple Sclerosis
Interventions: DRUG: Acyclovir|DRUG: Methylprednisolone|DRUG: alemtuzumab GZ402673|DRUG: alemtuzumab GZ402673|DRUG: Paracetamol|DRUG: Loratadine|DRUG: Ceterizine|DRUG: Dexchlorpheniramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Composite Cancellous and Demineralized Bone Plug (CR-Plug) for Repair of Knee Osteochondral Defects
Status: TERMINATED
Conditions: Knee Injury
Interventions: OTHER: Primary injury site|OTHER: Backfill site
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Dopamine, Reward Learning and Prefrontal Activity in Expectation-induced Mood Enhancement
Status: COMPLETED
Conditions: Placebo Effect on Mood Improvement
Interventions: DRUG: Sulpiride 400 MG|DRUG: Placebo|BEHAVIORAL: High expectation manipulation|BEHAVIORAL: Low expectation manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Meditation as Complementary Treatment for Chronic Hypertension in Pregnancy
Status: COMPLETED
Conditions: Hypertension, Pregnancy-Induced|Hypertension in Pregnancy|Hypertension
Interventions: OTHER: Meditation|OTHER: conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Study of Rapid Regadenoson Stress Cardiovascular Magnetic Resonance (CMR) to Detect Coronary Artery Disease
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: regadenoson
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Artesunate Plus Sulfadoxine-Pyrimethamine Versus Chloroquine for Vivax Malaria
Status: COMPLETED
Conditions: Malaria, Vivax
Interventions: DRUG: Sulfadoxine-pyrimethamine + artesunate|DRUG: Chloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of Inspiratory Muscle Training on the Severity of Obstructive Sleep Apnea in Individuals After Stroke
Status: COMPLETED
Conditions: Stroke|Obstructive Sleep Apnea|Inspiratory Muscle Training
Interventions: OTHER: Inspiratory Muscle Training|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Hybrid Ablation and Pulmonary Vein Isolation Alone vs Hybrid Ablation With PVI Plus Catheter Ablation
Status: WITHDRAWN
Conditions: Persistent Atrial Fibrillation
Interventions: DEVICE: Medtronic Cryoballoon|DEVICE: Thermocool Catheter|DEVICE: nContact
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Escalating Dose Pilot Trial of Canakinumab (ILARIS®) in Duchenne Muscular Dystrophy
Status: ACTIVE_NOT_RECRUITING
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: Canakinumab Injection [Ilaris]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to De-prescribe Inappropriate Medications in the Community Dwelling Elderly
Status: COMPLETED
Conditions: Inappropriate Dose of Drug Administered|Health Behavior
Interventions: BEHAVIORAL: Pharmacist-led educational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Dendritic Cell Vaccination in Melanoma Patients Scheduled for Regional Lymph Node Dissection
Status: COMPLETED
Conditions: Melanoma Stage III or IV
Interventions: BIOLOGICAL: Peptide-pulsed dendritic cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Change of Glucose Metabolism and Fibrosis Markers in Patients With Hepatitis C Under Treatment With Antiviral Agents
Status: COMPLETED
Conditions: Glucose Metabolism Disorders|Liver Fibrosis|Hepatitis C
Interventions: DIAGNOSTIC_TEST: Lab tests, non-invasive fibrosis (Fibroscan/ARFI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Progesterone & Postpartum Relapse to Smoking
Status: COMPLETED
Conditions: Tobacco Use Cessation|Tobacco Use Disorder
Interventions: DRUG: Progesterone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Urine Concentrations of Vilanterol After Inhaled Administration of Vilanterol/Fluticasone Furoate
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Fluticasone Furoate/ Vilanterol Trifenatate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Evaluating the Efficacy and Safety of ZG005 in Combination With Donafenib or Bevacizumab in Patients With Advanced Hepatocellular Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Advanced Hepatocellular Carcinoma
Interventions: BIOLOGICAL: ZG005 Powder for Injection|DRUG: Donafenib Tosilate Tablets|BIOLOGICAL: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Sucralose in Gut Intestinal Microbiota and Postprandial GLP-1
Status: COMPLETED
Conditions: GLP-1|Gut Microbiota
Interventions: OTHER: sucralose|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Improving Evidence-Based Care for Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer|Prostate Cancer|Breast Cancer|Lung Cancer|Gynecologic Cancer|Gastrointestinal Cancer
Interventions: OTHER: Survey|OTHER: Saliva sample|OTHER: Smoking Status questions
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Projection of Visual Material on Postoperative Delirium in Patients Undergoing Cardiac Surgery
Status: COMPLETED
Conditions: Delirium|Postoperative Delirium|Cardiac Surgery
Interventions: BEHAVIORAL: Projection of Visual Material on Postoperative Delirium in Patients Undergoing Cardiac Surgery|BEHAVIORAL: the usual unit treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Zinc Homeostasis and Kinetics in Children With Cystic Fibrosis (CF)
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Zinc acetate (20mg/d)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of GS-9716 as Monotherapy and in Combination With Anticancer Therapies in Adults With Solid Malignancies
Status: RECRUITING
Conditions: Solid Malignancies
Interventions: DRUG: GS-9716|DRUG: Docetaxel|DRUG: sacituzumab govitecan-hziy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Target-controlled Infusion With Propofol in the Emergency Department : a Prospective Study on 45 Adult Patients
Status: COMPLETED
Conditions: Joint Dislocation|Limb Fracture
Interventions: DRUG: Target control infusion with propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Consistency Between Measures of Renal Function in ICU Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Critical Illness
Interventions: DIAGNOSTIC_TEST: S Creatinine concentration|DIAGNOSTIC_TEST: Serum Cystatin C concentration|DIAGNOSTIC_TEST: Urinary Creatinine Clearance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multimodal Approach to the Ontogenesis of Nociception in Very Preterm and Term Infants
Status: RECRUITING
Conditions: Procedural Pain|Pre-Term|Venipuncture
Interventions: BEHAVIORAL: Maternal vocal contact
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effects of Amino Acid Supplementation on Liver Lipid Content and Protein Metabolism in Obese Children
Status: UNKNOWN
Conditions: Liver Steatosis|Insulin Resistance|Whole Body Protein Metabolism|Body Composition, Beneficial
Interventions: DIETARY_SUPPLEMENT: Essential amino acids plus arginine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison of CRP Levels, Neutrophil Count, and Clinical Outcomes of Low Dose Ketamine Between at Anesthesia Induction and at the End of Surgery in Patients Undergo Elective Laparotomy
Status: COMPLETED
Conditions: General Anesthesia|Laparotomy|Inflammation
Interventions: DRUG: Ketamine 0.3 mg/kg at end-of-surgery|DRUG: Ketamine 0.3 mg/kg at anesthesia induction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study to Compare Dental Plaque Control
Status: COMPLETED
Conditions: Dental Plaque
Interventions: DRUG: Fluoride|DRUG: Triclosan/Fluoride|DRUG: Triclosan/Fluoride|DRUG: Triclosan/Fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Treatment of Fever in Children Who Have Been Vaccinated With Prevenar and Infanrix Hexa
Status: COMPLETED
Conditions: Vaccines, Pneumococcal|Infant|Fever, Chemically Induced|Drug Therapy, Combination
Interventions: BIOLOGICAL: Prevenar|BIOLOGICAL: Infanrix hexa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Antitumor Study of ADCT-601 to Treat Advanced Solid Tumors
Status: TERMINATED
Conditions: Advanced Solid Tumors
Interventions: DRUG: ADCT-601
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing a Precision Psychotherapy System for Low-income Patients
Status: NOT_YET_RECRUITING
Conditions: Major Depressive Disorder|Dysthymic Disorder|Specific Phobia|Social Anxiety Disorder|Panic Disorder|Agoraphobia|Generalized Anxiety Disorder
Interventions: BEHAVIORAL: Pre-treatment psychotherapy recommendations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Sleep and AD Biomarkers
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Alzheimer Disease
Interventions: DIETARY_SUPPLEMENT: Citicoline Supplement|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Tenofovir Gel in the Prevention of Human Immunodeficiency Virus (HIV-1) Infection in Women and the Effects of Tenofovir Gel on the Incidence of Herpes Simplex Virus (HSV-2) Infection
Status: COMPLETED
Conditions: HIV Prevention
Interventions: DRUG: Tenofovir gel|DRUG: Universal placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Continuation of The Kronos Early Estrogen Prevention Study (KEEPS)
Status: COMPLETED
Conditions: Alzheimer Dementia
Interventions: DIAGNOSTIC_TEST: Brain Magnetic Resonance Imaging (MRI)|DIAGNOSTIC_TEST: F-18 Florbetapir Positron Emission Tomography (PET) Imaging|DIAGNOSTIC_TEST: F-18 AV-1451 Positron Emission Tomography (PET) Imaging|OTHER: Neuropsychological Testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigating the Effects of Sensory Input Orthotics in Disorders of Posture and Movement
Status: WITHDRAWN
Conditions: Cerebral Palsy
Interventions: DEVICE: Flexible orthotic|DEVICE: Standard orthotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prospective Study to Determine the Effect of Subconjunctival Bevacizumab (AVASTIN) in Corneal Neovascularization
Status: COMPLETED
Conditions: Corneal Neovascularization
Interventions: DRUG: Bevacizumab (Avastin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Zoledronic Acid to Prevent Bone Loss Following Denosumab Discontinuation
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoporosis|Osteoporosis, Postmenopausal|Osteopenia|Bone Loss
Interventions: DRUG: Zoledronic acid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transient Receptor Potential Channels
Status: NOT_YET_RECRUITING
Conditions: Aging
Interventions: DRUG: TRPM8 Agonist|DRUG: TRPV1 Agonist|DRUG: TRPV4 Agonist|DRUG: TRPM8, TRPV4, TRPV1 Agonists|OTHER: Vehicle gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prevalence of Periodontitis in Patients With Plaque Psoriasis. A Cross-sectional Study
Status: UNKNOWN
Conditions: Psoriasis|Plaque Psoriasis|Periodontal Diseases|Periodontitis
Interventions: DIAGNOSTIC_TEST: Full periodontal chart|OTHER: Saliva sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Olanzapine Treated Adolescents With Schizophrenia or Bipolar I Disorder
Status: COMPLETED
Conditions: Schizophrenia|Bipolar Disorder
Interventions: DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Simple Follow-up to Exploratory Laparotomy Plus "in Principle" (Hyperthermic Intraperitoneal Chemotherapy) HIPEC in Colorectal Patients
Status: UNKNOWN
Conditions: Colorectal Cancer With a Resected Minimal Synchronous PC|Ovarian Metastases|Tumour Rupture in the Abdominal Cavity
Interventions: PROCEDURE: laparotomy plus HIPEC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of APL180 in Healthy Volunteers and Patients With Coronary Heart Disease (CHD)
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DRUG: APL180|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Autologous Whole Blood Management for Transfusion Reduction in Adult Cardiac Surgery Patients
Status: RECRUITING
Conditions: Postoperative Hemorrhage|Postoperative Anemia|Postoperative Blood Loss
Interventions: OTHER: Autologous Whole Blood Management|OTHER: Standard Care involving allogenic and/or derivative transfusion.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prehabilitation in Gynaecological Cancer Patients
Status: RECRUITING
Conditions: Ovarian Cancer|Ovarian Cancer Stage III|Ovarian Cancer Stage IV|Endometrial Cancer|Frailty
Interventions: OTHER: Physiological intervention|BEHAVIORAL: Psychological intervention|DIETARY_SUPPLEMENT: Nutritional intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cetuximab and Everolimus in Treating Patients With Metastatic or Recurrent Colon Cancer or Head and Neck Cancer
Status: COMPLETED
Conditions: Recurrent Adenoid Cystic Carcinoma of the Oral Cavity|Recurrent Basal Cell Carcinoma of the Lip|Recurrent Colon Cancer|Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity|Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity|Recurrent Lymphoepithelioma of the Nasopharynx|Recurrent Lymphoepithelioma of the Oropharynx|Recurrent Metastatic Squamous Neck Cancer With Occult Primary|Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity|Recurrent Mucoepidermoid Carcinoma of the Oral Cavity|Recurrent Salivary Gland Cancer|Recurrent Squamous Cell Carcinoma of the Hypopharynx|Recurrent Squamous Cell Carcinoma of the Larynx|Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity|Recurrent Squamous Cell Carcinoma of the Nasopharynx|Recurrent Squamous Cell Carcinoma of the Oropharynx|Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Recurrent Verrucous Carcinoma of the Larynx|Recurrent Verrucous Carcinoma of the Oral Cavity|Stage IV Adenoid Cystic Carcinoma of the Oral Cavity|Stage IV Basal Cell Carcinoma of the Lip|Stage IV Lymphoepithelioma of the Nasopharynx|Stage IV Lymphoepithelioma of the Oropharynx|Stage IV Mucoepidermoid Carcinoma of the Oral Cavity|Stage IV Squamous Cell Carcinoma of the Hypopharynx|Stage IV Squamous Cell Carcinoma of the Larynx|Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IV Squamous Cell Carcinoma of the Nasopharynx|Stage IV Squamous Cell Carcinoma of the Oropharynx|Stage IV Verrucous Carcinoma of the Larynx|Stage IV Verrucous Carcinoma of the Oral Cavity|Stage IVA Colon Cancer|Stage IVA Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity|Stage IVA Inverted Papilloma of the Paranasal Sinus and Nasal Cavity|Stage IVA Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity|Stage IVA Salivary Gland Cancer|Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVB Colon Cancer|Stage IVB Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity|Stage IVB Inverted Papilloma of the Paranasal Sinus and Nasal Cavity|Stage IVB Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity|Stage IVB Salivary Gland Cancer|Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVC Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity|Stage IVC Inverted Papilloma of the Paranasal Sinus and Nasal Cavity|Stage IVC Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity|Stage IVC Salivary Gland Cancer|Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Tongue Cancer
Interventions: DRUG: everolimus|BIOLOGICAL: cetuximab|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT