pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: PH I Addition of Farnesyl Transferase Inhibitor to Temozolomide for Pts w Gr 3 & 4 Malignant Gliomas
Status: COMPLETED
Conditions: Gliosarcoma|Glioblastoma|Anaplastic Astrocytoma
Interventions: DRUG: Temodar and SCH 66336
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Added Value of Automated Electrical Source Localization (EPILOG PreOp®) to Presurgical Evaluation of Refractory Epilepsy
Status: UNKNOWN
Conditions: Epilepsies, Partial
Interventions: DIAGNOSTIC_TEST: electrical source imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: First-time-in-human (FTIH) Study of GSK3145095 Alone and in Combination With Other Anticancer Agents in Adults With Advanced Solid Tumors
Status: TERMINATED
Conditions: Neoplasms, Pancreatic
Interventions: DRUG: GSK3145095|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transanal Endoscopic Microsurgery (TEM) After Radiochemotherapy for Rectal Cancer
Status: COMPLETED
Conditions: Rectal Tumour
Interventions: DRUG: Capecitabine|RADIATION: radiotherapy|PROCEDURE: TME resection|PROCEDURE: TEM surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of a Preseasonal Treatment With AllerT in Subjects With Birch Pollen Allergy
Status: COMPLETED
Conditions: Allergic Rhinitis|Rhinoconjunctivitis
Interventions: DRUG: placebo|DRUG: AllerT low dose|DRUG: AllerT full dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retrolaminar Thoracic Paravertebral Block
Status: COMPLETED
Conditions: Regional Anesthesia Morbidity|Postoperative Pain
Interventions: PROCEDURE: Ordinary approach paravertebral block|PROCEDURE: Retrolaminar paravertebral block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: GIMEMA CLL0809 Study (BendOfa)
Status: COMPLETED
Conditions: Patients With CLL Relapsing After an Initial Response (CR, PR ≥ 6 Months) Following no More Than Two Prior Treatment Lines; or|Patients With CLL Refractory (SD, PD or CR/PR < 6 Months) Following no More Than Two Prior Treatment Lines
Interventions: DRUG: Ofatumumab|DRUG: Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Internal Radiation in Treating Patients With Colorectal Cancer That Has Spread to the Liver
Status: UNKNOWN
Conditions: Colorectal Cancer|Metastatic Cancer
Interventions: DRUG: floxuridine|DRUG: fluorouracil|DRUG: irinotecan hydrochloride|DRUG: leucovorin calcium|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetic Interaction Study of Tadalafil and Dutasteride
Status: COMPLETED
Conditions: Benign Prostate Hyperplasia
Interventions: DRUG: Tadalafil|DRUG: Dutasteride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: The Effect of Virtual Reality Goggles and Stress Ball Used During Intravenous Catheterization on Pain and Fear in Children
Status: NOT_YET_RECRUITING
Conditions: Pain, Procedural|Anxiety|Pain Management
Interventions: OTHER: intravenous catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 26 Weeks' Dietary Supplementation With DHA- and EPA-enriched Oils on Memory Consolidation in Healthy Adults
Status: COMPLETED
Conditions: Memory Consolidation
Interventions: DIETARY_SUPPLEMENT: Olive Oil Placebo|DIETARY_SUPPLEMENT: EPA-rich|DIETARY_SUPPLEMENT: DHA-rich
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Improving Patient Prioritization During Hospital-homecare Transition
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Congestive Heart Failure|Obstructive Pulmonary Disease|Dyspnea|Renal Failure
Interventions: OTHER: PREVENT clinical decision support
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Chitosan,Chitosan Nanoparticles,and Chlorhexidine Gluconate, as Intra Canal Medicaments in Primary Teeth
Status: UNKNOWN
Conditions: Necrotic Pulp
Interventions: DRUG: chitosan nanoparticles gel|DRUG: chitosan gel|DRUG: chlorhexidine gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Erlotinib or Sorafenib as First-Line Therapy in Treating Patients With Advanced Liver Cancer
Status: COMPLETED
Conditions: Liver Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: erlotinib hydrochloride|DRUG: sorafenib tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Maternal Hypotension During Cesarean Section With Norepinephrine Infusion.
Status: COMPLETED
Conditions: Hypotension|Obstetric Anesthesia Problems|Cesarean Section Complications|Hypotensive|Vasoconstriction
Interventions: PROCEDURE: norepinephrine infusion and colloid preloading (NOR-COL)|PROCEDURE: norepinephrine infusion and crystalloid co-loading (NOR-CRYST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sleep Disorders in Patients With Suspected Lung Cancer Before and After Thoracic Surgery
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: OTHER: Functional Outcome of Sleep Questionnaire Turkish version (FOSQ-TR)|OTHER: Epworth Sleepiness Scale (ESS)|OTHER: Berlin Questionnaire|OTHER: Stop-Bang Questionnaire|OTHER: Insomnia Questionnaire|OTHER: Restless Leg Syndrome Questionnaire|OTHER: Zung Self-rating Depression Scale (SDS)|OTHER: Beck Anxiety Inventory
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: In Vivo Evaluation of the Physiological Effects of Arabinoxylan-oligosaccharides (AXOS) in Healthy Subjects (Adults)
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: wheat bran extract|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate and Compare Injections of Autologous Mixed Population of Dermal Cells Into the Balding Scalp of Subjects With Hair Loss (CA-0004542)
Status: COMPLETED
Conditions: Androgenetic Alopecia|Male Pattern Baldness|Female Pattern Baldness
Interventions: BIOLOGICAL: Autologous cultured dermal and epidermal cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine as an Adjuvant for Femoral Nerve Block and Functional Recovery After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Elderly|Total Knee Arthroplasty|Femoral Nerve Block|Dexmedetomidine|Functional Outcome
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Medication Intake of Solid Dosage Forms: A Risk Factor for Patients With Stroke-induced Dysphagia?
Status: COMPLETED
Conditions: Cerebral Infarction|Stroke, Acute|Stroke|Dysphagia
Interventions: OTHER: Solid Medication intake vs. crushed medication intake
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of a Vaccination Against COVID-19 on Monocyte Production of Oxygenated Derivatives.
Status: ACTIVE_NOT_RECRUITING
Conditions: CORONAVIRUS INFECTIONS
Interventions: BIOLOGICAL: anti-SARS-Cov-2 vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Role of Central Serotonergic and Adrenergic Systems in the Effectiveness of DNIC (Diffuse Noxious Inhibitory Control
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Emergency PWAS in Respiratory Infectious Disease
Status: RECRUITING
Conditions: Viral Infections|Bacterial Infections|Fungal Infections|Mixed Infection|Mycobacterium Infection|Infection of Uncertain Aetiology|Pneumonia|Sepsis
Interventions: DIAGNOSTIC_TEST: Biomarker blood draw and saliva collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of the TGF-beta Pathway and Micro-RNA in Pediatric Pulmonary Arterial Hypertension
Status: UNKNOWN
Conditions: Pulmonary Arterial Hypertension
Interventions: DIAGNOSTIC_TEST: Protein Elisa analysis, microRNA analysis, whole exome sequencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chemotherapy With Pemetrexed in Combination With Platinum for Advanced Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-Small-Cell Lung Cancer
Interventions: DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Validation of a Driving Simulator for Evaluating the Residual Effects of Drugs on Driving Performance - Sensitivity Analysis Using Zopiclone as a Positive Control
Status: COMPLETED
Conditions: Healthy Participants
Interventions: OTHER: Road-tracking test|OTHER: Car-following test|OTHER: Harsh-braking test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Assessment of the Effect of Clonidine for Cataract Surgery
Status: UNKNOWN
Conditions: Pain|Arrythmia
Interventions: DRUG: Clonidine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta
Status: RECRUITING
Conditions: Osteogenesis Imperfecta
Interventions: DRUG: Romosozumab|DRUG: Bisphosphonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Mirabegron in Intracerebral Hemorrhage
Status: RECRUITING
Conditions: Intracerebral Haemorrhage
Interventions: DRUG: Standard treatment+mirabegron|OTHER: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Evaluation of Azimilide or Sotalol vs Placebo for Treatment of Patients With Atrial Fibrillation.
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Azimilide Dihydrochloride|DRUG: Placebo|DRUG: Sotalol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Develop Novel Phototherapy for Health Care of Patients With Sleep Disorder, Mild Cognitive Impairment, or Dementia
Status: COMPLETED
Conditions: Dementia|Sleep Disorder|Mild Cognitive Impairment|Phototherapy
Interventions: DEVICE: Green LED light|DEVICE: Red LED light (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Test the Safety, Tolerability and Efficacy of UCB7665 in Subjects With Moderate to Severe Myasthenia Gravis
Status: COMPLETED
Conditions: Myasthenia Gravis
Interventions: DRUG: UCB7665|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Deep Learning Signature for Predicting Complete Pathological Response to Neoadjuvant Chemoimmunotherapy in Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer|Neoadjuvant Chemoimmunotherapy|Complete Pathological Response
Interventions: DIAGNOSTIC_TEST: CT/PET/WSI-based Deep Learning Signature
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Study Between The Efficacy Of Quadratus Lumborum Block VS Conventional Analgesia In Patients Undergoing Open Inguinal Hernia Surgical Repair
Status: COMPLETED
Conditions: Analgesia in Patients With Open Inguinal Hernia Surgeries
Interventions: DRUG: Bupivacaine infiltration at the Quadratus Lumborum muscle Versus Paracetamol injection as analgesia in post operative Open Inguinal Hernia surgeries
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of IMCnyeso in Advanced NY-ESO-1 and/or LAGE-1A Positive Cancers
Status: TERMINATED
Conditions: Select Advanced Solid Tumors
Interventions: DRUG: IMCnyeso
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Survivorship Among Minority Cancer Dyads
Status: WITHDRAWN
Conditions: Cancer|Breast Cancer|Colon Cancer|Caregiver Burnout|Lung Cancer
Interventions: BEHAVIORAL: Change in knowledge, motivation, skills, and resources
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Study of a Selective Serotonin Partial Agonist and Reuptake Inhibitors, HEC113995PA•H2O,in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HEC113995PA•H2O tablet|DRUG: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 2 Study Evaluating the Efficacy of the Combination of DKN-01 (DKK1 Inhibitor, Leap Therapeutics) and Pembrolizumab in the Treatment of Advanced or Recurrent Endometrial Cancer
Status: RECRUITING
Conditions: Endometrial Cancer
Interventions: DRUG: DKN-01|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ZYIL1 in Subjects With Cryopyrin Associated Periodic Syndromes (CAPS)
Status: COMPLETED
Conditions: Cryopyrin Associated Periodic Syndrome
Interventions: DRUG: ZYIL1 capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prucalopride Effects on Subjects With Chronic Non-cancer Pain Suffering From Opioid Induced Constipation
Status: TERMINATED
Conditions: Non-cancer Pain|Opioid Induced Constipation
Interventions: DRUG: placebo|DRUG: prucalopride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Remdesivir in Participants With Severely Reduced Kidney Function Who Are Hospitalized for Coronavirus Disease 2019 (COVID-19)
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Remdesivir|DRUG: RDV Placebo|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of AZD5148 in Healthy Adults
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: AZD5148|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Cardiorespiratory Effects of "Higher" Versus "Equivalent" CPAP Upon Extubation From High EAP in Preterm Infants
Status: UNKNOWN
Conditions: Preterm Infant
Interventions: PROCEDURE: Extubation from endotracheal mechanical ventilation to CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Acetyl Hexapeptide-8 (AH8) in Treatment of Blepharospasm
Status: COMPLETED
Conditions: Focal Dystonia
Interventions: DRUG: Acetyl-Hexapeptide Topical Treatment|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Propofol Versus Midazolam for Lower Gastrointestinal Endoscopy
Status: UNKNOWN
Conditions: Cirrhosis, Liver
Interventions: DRUG: Midazolam|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate Both The Efficacy and Safety Profile of CP-690,550 In Patients With Moderately to Severely Active Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: tofacitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of the Modified Beef Tongue Model for Teaching Repair of Obstetrical Fourth-Degree Laceration to Residents
Status: COMPLETED
Conditions: Fourth Degree Perineal Laceration Involving Anal Mucosa|Obstetric; Injury|Obstetric Labor Complications
Interventions: OTHER: Instructional video|OTHER: Instructional workshop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pemetrexed and Temozolomide in Treating Patients With Relapsed Primary Central Nervous System Lymphoma （PCNSL）
Status: UNKNOWN
Conditions: Central Nervous System Tumors
Interventions: DRUG: Pemetrexe|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The S.A.F.E. Study : Computer-Aided Counseling to Prevent Teen Pregnancy/Sexually Transmitted Diseases (STDs)
Status: COMPLETED
Conditions: Pregnancy|Sexually Transmitted Diseases
Interventions: BEHAVIORAL: Computer-Assisted Motivational Intervention|BEHAVIORAL: Didactic Educational Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Obinutuzumab to Evaluate Safety and Tolerability in Hypersensitized Adult Participants With End Stage Renal Disease Awaiting Transplantation
Status: COMPLETED
Conditions: Kidney Failure, Chronic
Interventions: DRUG: Obinutuzumab|DRUG: Intravenous Immunoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Cognitive Behavioral Therapy for Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia|Schizoaffective Disorder|Delusional Disorder
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases|Type 2 Diabetes Mellitus
Interventions: DRUG: Apelin|DRUG: Relaxin|DRUG: Normal saline|DIAGNOSTIC_TEST: Verapamil|DIAGNOSTIC_TEST: LN Monomethyl arginine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Phase II Study of Dose-Dense Doxurubicin and Cyclophosphamide (AC) Followed By Paclitaxel With Trastuzumab in HER2/ NEU-Amplified Breast Cancer: Feasibility
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: AC [Adriamycin (A) (also known as doxorubicin) and Cyclophosphamide (C)] Followed By Paclitaxel (P)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Study Generic Diclofenac Sodium Topical Gel 1% in the Treatment of Osteoarthritis of the Knee (Degenerative Joint Disease Presented as Joint Pain, Stiffness, Swelling and Restricted Motion).
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Diclofenac Sodium gel, 1%|DRUG: Voltaren® Gel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Noninvasive Vagus Stimulation for Upper Extremity in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease|Upper Extremity Dysfunction|Tremor
Interventions: DEVICE: noninvasive vagus nerve srimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Efficacy of Telerehabilitation in Patients With Rotator Cuff Tendinopathy
Status: COMPLETED
Conditions: Rotator Cuff Injuries|Rotator Cuff Tendinitis
Interventions: OTHER: Telerehabilitation|OTHER: home exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-site Transcranial Magnetic Stimulation Therapy of the Supplementary Motor Area in Children With Tourette Syndrome
Status: WITHDRAWN
Conditions: Tourette Syndrome
Interventions: DEVICE: Active Treatment|DEVICE: Sham Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging Tumor Hypoxia With 18F-EF5 PET in Recurrent or Metastatic Clear Cell Ovarian Cancer
Status: TERMINATED
Conditions: Ovarian Cancer|Ovarian Neoplasms
Interventions: DRUG: 18F-EF5 PET/CT scan|PROCEDURE: Optional biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of the Safety and Effectiveness of NXN-188 for the Treatment of Migraine Headache Without Aura
Status: COMPLETED
Conditions: Migraine Without Aura
Interventions: DRUG: NXN-188|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Total Neoadjuvant Treatment for pMMR Locally Advanced Low Rectal Cancer: Anti-PD-1 Antibody With FOLFOXIRI and Preoperative Radiation Therapy
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: Serplulimab + FOLFOXIRI|RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MicroPhage S. Aureus / MSSA / MRSA Blood Culture Beta Trial
Status: COMPLETED
Conditions: Bacteremia|Staphylococcal Infection|Sepsis|Infection
Interventions: OTHER: MicroPhage S. aureus / MSSA / MRSA Blood Culture Test (prototype)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Acute Responses of Postural Alignment, Kinematic Synergy, and Intermuscular Coherence to Postural Muscle Facilitation (Retrospective)
Status: COMPLETED
Conditions: Posture|Musculoskeletal Equilibrium
Interventions: OTHER: Exercise Then Foam Roll|OTHER: Foam Roll Then Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Improve Acute Reperfusion Treatment Quality for Ischemic Stroke Through Spatiotemporal Computing in China
Status: NOT_YET_RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: BEHAVIORAL: improvement acute reperfusion treatment quality for stroke through spatiotemporal computing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Radial Shock Wave and Acupuncture for Myofascial Pain
Status: COMPLETED
Conditions: Myofascial Pain
Interventions: DEVICE: Radial shock wave|DEVICE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Online Therapy for Posttraumatic Stress Symptoms in WTC Responders and Survivors
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: BEHAVIORAL: Online Cognitive-Behavioral Therapy|BEHAVIORAL: Online Supportive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Stromal Vascular Fraction of Cells for Treatment of Knee Articular Cartilage Dystrophy
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Liposuction|OTHER: SVF isolation|OTHER: Intraarticular administration of autologous SVF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retention Rate of Giomer Pit and Fissure Sealant Applied With or Without Etching
Status: ACTIVE_NOT_RECRUITING
Conditions: Caries Prevention
Interventions: DRUG: Giomer pit and fissure sealant without etching|DRUG: Giomer pit and fissure sealant with etching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MRI of Myocardial Infarction
Status: RECRUITING
Conditions: Myocardial Infarction|Myocardial Ischemia|Myocardial Injury|Myocardial Fibrosis|Myocardial Reperfusion Injury|Myocardial Edema|Myocardial Necrosis|Heart Failure|Ischemic Heart Disease|Ischemic Cardiomyopathy|Hemorrhage
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ALP-1 Continuous Intravenous Infusion to Maintain Clinical Stability in Advanced Heart Failure
Status: NOT_YET_RECRUITING
Conditions: Heart Failure
Interventions: DRUG: Alprostadil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Nanotechnology Structured Water to Control Blood Glucose in Type 2 Diabetic Patients.
Status: COMPLETED
Conditions: Type2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Nanotechnology structured water ( Magnalife)|DIETARY_SUPPLEMENT: ordinary water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hypertension and Osteopathic Treatment
Status: WITHDRAWN
Conditions: Prehypertension|Hypertension|Osteopathic Manipulation|Sympathetic Nervous System
Interventions: PROCEDURE: Osteopathic Manipulative Therapy|BEHAVIORAL: Lifestyle Modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Single Agent Brentuximab Vedotin in Relapsed/Refractory CD30 Low (<10%) Mature T Cell Lymphoma (TCL)
Status: RECRUITING
Conditions: T-cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Hepato-splenic T-cell Lymphoma|Adult T-cell Leukemia/Lymphoma|Enteropathy Associated T-cell Lymphoma|NK T-cell Lymphoma
Interventions: DRUG: Brentuximab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodal Analgesia in Laparoscopic Radical Gastrectomy With Gastric Cancer: a Multi-center Study
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: PROCEDURE: Multimodal analgesia|PROCEDURE: PCIA analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Ultrasound-guided Genicular Nerve Block in Knee Osteoarthritis Patients on Proprioception and Static Balance
Status: COMPLETED
Conditions: Osteoarthritis|Osteoarthritis, Knee|Proprioceptive Disorders|Balance; Distorted
Interventions: DRUG: Genicular blocks (dexamethazone and lidocaine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Repeat Doses of PF-06372865 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Placebo|DRUG: PF-06372865
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Oral Bioavailability of Two Solid Formulations of GLPG0259.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG0259 fumarate|DRUG: GLPG0259 free base
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Understanding Motivation in Parkinson's Patients Through Neurophysiology
Status: RECRUITING
Conditions: Parkinson Disease|Deep Brain Stimulation|Motivation
Interventions: OTHER: Stimulation on|OTHER: Stimulation off|BEHAVIORAL: Decision Making Task
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of a New MVA Vaccine for Hepatitis C Virus
Status: COMPLETED
Conditions: Hepatitis C Infection
Interventions: BIOLOGICAL: MVA-NSmut|BIOLOGICAL: AdCh3NSmut|BIOLOGICAL: AdCh3NSmut1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-omics Model Predicts Efficacy of Preoperative Neoadjuvant Chemoradiotherapy Combined PD-1 Antibody Therapy for Locally Advanced Rectal Cancer
Status: UNKNOWN
Conditions: Colorectal Neoplasms
Interventions: COMBINATION_PRODUCT: long course radiotherapy + capecitabine + PD-1 monoclonal antibody
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Tolerability, Pharmacokinetics,Pharmacodynamics Study of LAPS-Exendin in Subjects of Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: HM11260C|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intervention to Reduce Implicit Bias in Pharmacies
Status: NOT_YET_RECRUITING
Conditions: Bias, Implicit|HIV|Pre-exposure Prophylaxis
Interventions: BEHAVIORAL: The adapted PHBI|BEHAVIORAL: The NIH Implicit Bias course
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Immunogenicity of Glycovax-002 Vaccine in Healthy Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: SARS-CoV-2
Interventions: BIOLOGICAL: Glycovax-002
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: UCSF PANC Cyst Registry
Status: RECRUITING
Conditions: Pancreatic Cyst|Pancreatic Neoplasms|Pancreatic Cancer|Pancreatic Diseases|Pancreatic Intraductal Papillary Mucinous Neoplasm|Intraductal Papillary Mucinous Neoplasm|Pancreatic Ductal Adenocarcinoma|Mucinous Cyst
Interventions: OTHER: Survey
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE)
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Medical Chitosan|DRUG: Sodium Hyaluronate Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Smoking on Postprandial Gastric Emptying, Glucose Tolerance and Secretion of Gut and Pancreatic Hormones
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Liquid mixed meal|OTHER: Skin Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mild Cognitive Impairment and Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Mild Cognitive Impairment
Interventions: BEHAVIORAL: CPAP adherence intervention|BEHAVIORAL: Attention control intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Real-time Computer-Aided Detection of Colonic Adenomas With NEC WISE VISION® Endoscopy
Status: RECRUITING
Conditions: Colorectal Cancer|Adenoma Colon|Polyp of Colon
Interventions: DIAGNOSTIC_TEST: Computer Aided Detection (CADe)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Repetitive Transcranial Magnetic Stimulation on Cognitive Impairment in Parkinson's Disease (PD)
Status: COMPLETED
Conditions: Parkinson's Disease With Cognitive Impairment
Interventions: DEVICE: repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Thrombolysis of Urokinase for Minor Stroke
Status: COMPLETED
Conditions: Minor Stroke
Interventions: DRUG: Urokinase thrombolysis|DRUG: Aspirin;Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pragmatic Randomized Controlled Trial to Predict Postpartum Hemorrhage
Status: NOT_YET_RECRUITING
Conditions: Post Partum Hemorrhage
Interventions: BEHAVIORAL: Novel PPH Risk Prediction Model - Comparator Arm B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Meperidine Versus Drotaverine Regarding the Effect on the Duration of the First Stage of Labor in Full Term Primigravidae
Status: UNKNOWN
Conditions: Effect of Meperidine or Drotaverine on Effacement and Dilatation of the Cervix During Labor in Full Term Primigravidae
Interventions: DRUG: Meperidine|DRUG: Drotaverine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficiency and Safety of Prophylactic Use of Antibiotics in Endoscopic Injection of Tissue Adhesive in Gastric Varices
Status: UNKNOWN
Conditions: Gastric Varices|Cirrhosis
Interventions: DRUG: Cefotiam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability Study of Oral NS-018 in Patients With Primary Myelofibrosis (MF), Post-polycythemia Vera MF or Post-essential Thrombocythemia MF
Status: COMPLETED
Conditions: Primary Myelofibrosis|Post-Polycythemia Vera Myelofibrosis|Post-Essential Thrombocythemia Myelofibrosis
Interventions: DRUG: NS-018
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of Colcrys® Crushed and Sprinkled on Applesauce
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Colchicine 0.6 mg tablet|DRUG: Colchicine 0.6 mg tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Induction of Migraine Aura With Sildenafil
Status: COMPLETED
Conditions: Migraine With Aura
Interventions: DRUG: Sildenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Launch II: A Pilot Randomized Control Trial of a Clinic and Clinic Plus Home Intervention for Preschool Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Clinic + Home Behavioral Intervention|OTHER: Pediatrician Counseling|BEHAVIORAL: Clinic Only Behavioral Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TEAM: Testosterone Supplementation and Exercise in Elderly Men
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LowT|BEHAVIORAL: Resistance Training|DRUG: Placebo|DRUG: HighT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Liver Ablation Assisted With Intra-Arterial CT Hepatic Arteriography and Ablation Confirmation Software Assessment (STEREOLAB)
Status: RECRUITING
Conditions: Liver Ablation|Hepatic
Interventions: PROCEDURE: Liver ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety Study of Ranibizumab Eye Injections to Treat Choroidal Neovascularization That Was Caused Other Than by Age-Related Macular Degeneration.
Status: COMPLETED
Conditions: Choroidal Neovascularization
Interventions: DRUG: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgery With or Without Chemotherapy and Radiation Therapy in TreatingPatients With Stage I Rectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: fluorouracil|DRUG: leucovorin calcium|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repeatability and Reproducibility of Lens Zonule Length Measurement Using ArcScan Insight 100
Status: ACTIVE_NOT_RECRUITING
Conditions: Zonule of Zinn Abnormality|Zonular Cataract
Interventions: DEVICE: ArcScan Insight 100 very high-frequency digital ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Beneficial Effects of Long Term Menaquinone-7
Status: COMPLETED
Conditions: Bone Loss|Arteriosclerosis
Interventions: DIETARY_SUPPLEMENT: menaquinone-7|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rifaximin and Propranolol Combination Therapy Versus Propranolol Monotherapy in Cirrhotic Patients
Status: UNKNOWN
Conditions: Liver Cirrhosis|Portal Hypertension
Interventions: DRUG: Rifaximin + propranolol|DRUG: Propranolol + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of a Trifocal Intraocular Lens (IOL) POD L GF in Comparison With a Multifocal and a Monofocal IOL
Status: COMPLETED
Conditions: Aphakia, Postcataract|Cataract; Eye Disease
Interventions: DEVICE: POD L GF IOL|DEVICE: Symfony® IOL|DEVICE: AcrySof® IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Efficacy and Safety ICATIBANT For The Treatment of Patients With SARS-CoV-2 (COVID-19) Infection
Status: COMPLETED
Conditions: COVID-19 Pneumonia
Interventions: DRUG: Firazyr|OTHER: SoC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different PEEP Settings of COVID-19 Induced ARDS
Status: COMPLETED
Conditions: COVID-19|Mechanical Ventilation Pressure High|Acute Respiratory Distress Syndrome
Interventions: OTHER: Gas exchanges at different PEEP|OTHER: lung mechanics at different PEEP|OTHER: Hemodynamics changes at different PEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conservative Non-Invasive Versus Routine Invasive Management in Coronary Artery Bypass Surgery Patients With Non ST Elevation Elevation Acute Coronary Syndrome
Status: COMPLETED
Conditions: Non ST Elevation Myocardial Infarction|Unstable Angina
Interventions: PROCEDURE: Invasive management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determine the Effect on Cognitive Impairment Measures by Providing Hearing-Assistance to Skilled Nursing Facility Residents
Status: WITHDRAWN
Conditions: Hearing Impairment
Interventions: DIAGNOSTIC_TEST: cognitive testing with HAD (PockeTalker) First|DIAGNOSTIC_TEST: Cognitive testing without HAD First
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Waitlist Controlled Comparison of Cognitive-behavioral vs. Mindfulness-based Online-treatments for Women With Low Sexual Desire
Status: COMPLETED
Conditions: Hypoactive Sexual Desire Disorder
Interventions: BEHAVIORAL: Cognitive-behavioral treatment|BEHAVIORAL: Mindfulness-based treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ph2, Study to Assess the Safety and Efficacy of GPC 100 and Propranolol With and Without G-CSF for the Mobilization of Stem Cells in Patients With Multiple Myeloma Undergoing Autologous Stem Cell Transplant
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: GPC-100|DRUG: Propranolol|DRUG: G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK,PD,Safety and Tolerability of Multiple Dose Regimens of MT-3724 With Gemcitabine and Oxaliplatin for the Treatment of Patients With Relapsed/Refractory Diffuse Large B Cell Non-Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Non-hodgkin Lymphoma,B Cell|Refractory Diffuse Large B-Cell Lymphoma|Relapsed Diffuse Large B-Cell Lymphoma
Interventions: DRUG: MT-3724|DRUG: Gemcitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tramadol Versus Diclofenac for Reducing Pain Before Outpatient Hysteroscopy
Status: UNKNOWN
Conditions: Pain, Post Procedural|Pain, Procedural
Interventions: DRUG: Tramadol|DRUG: Diclofenac|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Study of Everolimus in the Treatment of Advanced Malignancies in Patients With Peutz-Jeghers Syndrome
Status: WITHDRAWN
Conditions: Peutz-Jeghers Syndrome|Neoplastic Processes|Neoplasm Metastasis
Interventions: DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Randomized Trial of Hand-assisted Laparoscopic Right Hemicolectomy vs Total Laparoscopic Right Hemicolectomy
Status: COMPLETED
Conditions: Operation Time|Pain Score|Recurrence|Survival
Interventions: PROCEDURE: hand-assisted laparoscopic right hemicolectomy|PROCEDURE: total laparoscopic right hemicolectomy|PROCEDURE: hand-assisted right hemicolectomy|PROCEDURE: laparoscopic right hemicolectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Novel Biomarkers of Preeclampsia, Aquaporin, Fatty Acid, and S110B
Status: COMPLETED
Conditions: Preeclampsia
Interventions: OTHER: Women w/ Preeclampsia w/o Visual Disturbances or Headache|OTHER: Women w/ Preeclampsia w/ Visual Disturbances or Headaches|OTHER: Women w/o Preeclampsia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transcranial Doppler During Liver Transplantation
Status: UNKNOWN
Conditions: Liver Transplantation|Ultrasonography, Doppler, Transcranial|Complication, Postoperative|Neurologic Deficits
Interventions: DIAGNOSTIC_TEST: Transcranial Doppler
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study to Explore Association of Treatment Regimens for Visceral Leishmaniasis, Host Immunological, Genetical and Nutrition Factors With Post-kala-azar Dermal Leishmaniasis (PKDL)
Status: COMPLETED
Conditions: Post-kala-azar Dermal Leishmaniasis
Interventions: DRUG: Mitefosine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT