pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Impact of Magnetic Resonance and Biomarkers for Screening for Prostate Cancer. Cost-effectiveness Analysis
Status: UNKNOWN
Conditions: Establish the Efficacy Between the Four Schemes in Terms of the Aggressiveness of the Tumors According to the Gleason Classification|Establish the Efficacy Between the Four Schemes in Terms of Morbidity Associated With the Technique|Establish the Efficacy Between the Four Schemes in Terms of the Patient's Subjective Perception Regarding Pain and Quality of Life|Establish the Association of the Tumor Biomarker in the Early Detection and Aggressiveness of Tumors|Establish the Possible Interaction Between Biomarkers and Resonance in Different Prostate Biopsy Models to Define Tumor Presence and / or Tumor Aggressiveness|Establish the Possible Relationship Between the Expression Profiles of the microRNAs|Establish if There Are Differences Between Transrectal and Transperineal Prostatic Biopsy Schemes in Both Cases With and Without MRI
Interventions: PROCEDURE: Multiparametric magnetic resonance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison Of Uninclined And Inclined Treadmill Training In Obese Adults.
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: Inclined Treadmill Training|OTHER: Uninclined Treadmill Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: to Assess the Efficacy and Safety of the Probiotic E. Coli Strain M17 on Patients With GERD
Status: COMPLETED
Conditions: GERD
Interventions: DRUG: ProBactrix
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Trapeziometacarpal Splint
Status: COMPLETED
Conditions: Osteoarthritis of Trapeziometacarpal Joint
Interventions: DEVICE: Day Splint|DEVICE: Night Splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retrospective Analysis of Performance and Treatment Data Collected for Genius SleddFlux Filter, Ultraflux AV 600 S Filter & Genius 90 Concentrates in Haemodialysis Patients
Status: RECRUITING
Conditions: Renal Failure|End Stage Renal Disease|Acute Renal Failure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nimotuzumab Combined With VMAT in Elderly Patients With Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Nimotuzumab|RADIATION: VMAT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation HEC121120 Tolerance in Healthy Subjects and Patients With Chronic Hepatitis B, Pharmacokinetics Characteristics and Antiviral Activity of Ⅰ Phase of Study
Status: TERMINATED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: HEC121120 tablets|DRUG: HEC121120 placebo tablets|DRUG: entecavir tablets|DRUG: entecavir placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PXD101 in Treating Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Recurrent Adult Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: belinostat|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of Avelumab In Patients With Locally Advanced Or Metastatic Urothelial Cancer (JAVELIN Bladder 100)
Status: COMPLETED
Conditions: Urothelial Cancer
Interventions: BIOLOGICAL: Avelumab|OTHER: Best Supportive Care|BIOLOGICAL: Following the planned interim analysis for this study: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of CDE100 in the Treatment of Menstrual Cramp Pain Associated With Primary Dysmenorrhea
Status: NOT_YET_RECRUITING
Conditions: Primary Dysmenorrhea
Interventions: DRUG: CDE100 association|DRUG: Buscopan® Composto association
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Factors Associated With Obesity in Adult Women: Respiratory Exchange Ratio, Heart Rate Variation and Body Image
Status: COMPLETED
Conditions: Obesity
Interventions: DEVICE: Respiratory exchange ratio|DEVICE: Heart rate variability|DEVICE: Body composition|BEHAVIORAL: Eating behavior|BEHAVIORAL: Physical activity recall|BEHAVIORAL: Depression|BEHAVIORAL: Body image
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase II Trial Neoadjuvant Paclitaxel and Cisplatin in Patients With Locally Advanced Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: Paclitaxel|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pivotal Trial (D02) of Vagus Nerve Stimulation (VNS) for Treatment-Resistant Depression (TRD)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: vagus nerve stimulation (VNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CONNECTing to LungCare
Status: NOT_YET_RECRUITING
Conditions: Smoking Cessation|Cigarette Smoking-Related Carcinoma|Lung Carcinoma
Interventions: BEHAVIORAL: Smoking Cessation Intervention|OTHER: Saliva Collection|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: HRQOL of Life After ECMO Due to COVID-19.
Status: RECRUITING
Conditions: ARDS|COVID-19 Pneumonia|Extracorporeal Membrane Oxygenation
Interventions: OTHER: Phone Interview
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Using Multimedia Approaches to Communicate Probabilities in Patient Decision Aids for Low-Literacy Populations: Randomized Trial
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BEHAVIORAL: Booklet|BEHAVIORAL: Audio CD|BEHAVIORAL: Video with Non-Moving Images|BEHAVIORAL: Video with Animated Images|BEHAVIORAL: Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cognitive Behavioural Treatment of Intra-oral Injection-phobia in 10-16 Year Old Children and Adolescents
Status: COMPLETED
Conditions: Dental Anxiety
Interventions: BEHAVIORAL: 5 session of CBT performed by specially trained dentists
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dispensing Evaluation of New Daily Disposable Toric Soft Contact Lens.
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: Etafilcon A toric contact lens|DEVICE: Nelfilcon A toric contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate IAH0968 in Combination With CAPEOX in HER2-positive Gastric Cancer
Status: NOT_YET_RECRUITING
Conditions: Stomach Neoplasms|Solid Tumor
Interventions: DRUG: IAH0968
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intensified Transcranial Direct Current Stimulation in Obsessive-compulsive Disorder
Status: COMPLETED
Conditions: Obsessive-Compulsive Symptom
Interventions: DEVICE: transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Pegylated Interferon Lambda Plus Single or 2 Direct Antiviral Agents With Ribavirin
Status: COMPLETED
Conditions: Hepatitis C
Interventions: BIOLOGICAL: Pegylated Interferon Lambda (pegIFNλ)|DRUG: BMS-790052 (NS5A Inhibitor)|DRUG: Ribavirin (RBV)|DRUG: BMS-650032 (NS3 Protease Inhibitor)|BIOLOGICAL: Pegylated Interferon Alfa-2a (pegIFNα-2a)|BIOLOGICAL: Pegylated Interferon Lambda (pegIFNλ)|DRUG: Ribavirin (RBV)|BIOLOGICAL: Pegylated Interferon Lambda (pegIFNλ)|DRUG: Ribavirin (RBV)|DRUG: BMS-790052 (NS5A Inhibitor)|DRUG: BMS-650032 (NS3 Protease Inhibitor)|DRUG: Placebo (PBO) for BMS-650032 (Placebo for NS3 Protease Inhibitor)|DRUG: Placebo (PBO) for BMS-790052 (Placebo for NS5A Inhibitor)|DRUG: Placebo for Ribavirin (RBV)|DRUG: Placebo for Ribavirin (RBV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools
Status: UNKNOWN
Conditions: Pituitary Neoplasms|Prolactinoma|ACTH-Secreting Pituitary Adenoma|Gigantism|Growth Hormone-Secreting Pituitary Adenoma
Interventions: OTHER: Educational Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Risperidone vs. Olanzapine as add-on Treatment in Treatment Resistant Depression
Status: COMPLETED
Conditions: Subjects Had Unipolar, Non-psychotic Major Depression
Interventions: DRUG: Risperidone|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lymphocyte Re-infusion During Immune Suppression to Treat Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma|Neoplasm Metastasis
Interventions: DRUG: gp100:209-217 (210M)|DRUG: Montanide ISA-51|DRUG: IL-2|DRUG: MART-1:26-35(27L)|BIOLOGICAL: Abl cells|DRUG: Fludarabine|DRUG: Cyclophosphamide|BIOLOGICAL: GCSF (Growth colony stimulating factor)|PROCEDURE: Apheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sacral Erector Spinae Plane Block in Normal Birth
Status: RECRUITING
Conditions: Analgesia
Interventions: OTHER: % 0.25 bupivakain 20cc|OTHER: 20 cc saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Thinking Healthy Program - Peer Delivered, India (THPP-I)
Status: COMPLETED
Conditions: Unipolar Depression
Interventions: BEHAVIORAL: THPP-I|BEHAVIORAL: EUC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraarticular Glucose Versus Hyaluronic Acid Injection for Knee Osteoarthrosis
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DRUG: glucose water|DRUG: hyaluronic aicd
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of 7-day PPI-based Standard Triple Therapy and 10-day Bismuth Quadruple Therapy for H. Pylori Eradication
Status: COMPLETED
Conditions: Helicobacter Pylori Infection|Family History of Stomach Cancer
Interventions: DRUG: Standard triple therapy|DRUG: Bismuth quadruple therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 1L- vs. 4L-PEG for Bowel Preparation Among Inpatients.
Status: COMPLETED
Conditions: Colonoscopy|Hospitalized Patients|Bowel Preparation
Interventions: DRUG: 1L-PEG|DRUG: 4L-PEG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Sodium Thiosulfate in Shoulder Pain in Calcific Tendinitis of the Rotator Cuff
Status: UNKNOWN
Conditions: Sodium Thiosulfate|Calcific Tendinitis|Shoulder Pain
Interventions: DRUG: Sodium Thiosulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sirolimus, Tacrolimus, Thymoglobulin and Rituximab as Graft-versus-Host-Disease Prophylaxis in Patients Undergoing Haploidentical and HLA Partially Matched Donor Hematopoietic Cell Transplantation
Status: TERMINATED
Conditions: Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Lymphoma|Lymphoproliferative Disorder|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: BIOLOGICAL: anti-thymocyte globulin|BIOLOGICAL: rituximab|DRUG: sirolimus|DRUG: tacrolimus|OTHER: laboratory biomarker analysis|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: management of therapy complications|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chronic Care Management for Adults at FQHCs
Status: UNKNOWN
Conditions: Any Condition in N73.0 Specified as Chronic
Interventions: OTHER: Active self-management intervention|OTHER: Attention control phone calls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Optimization of Iron Bioavailability of Supplements Using Hepcidin Levels in Humans
Status: COMPLETED
Conditions: Iron Deficiency
Interventions: DIETARY_SUPPLEMENT: 60 mg Fe as FeSO4 with stable isotopic labels
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Performance and Safety of the Medical Device Argogen
Status: NOT_YET_RECRUITING
Conditions: Burn Wound|Pressure Ulcers Stage II|Pressure Ulcers Stage III
Interventions: DEVICE: Argogen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Compare the Effect of Vildagliptin Compared to Placebo in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of Brassica or Indole-3-carbinol on Prostatectomy Patients With PSA Recurrence
Status: COMPLETED
Conditions: Biochemical Failure
Interventions: DIETARY_SUPPLEMENT: brassica intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Intrauterine Device Insertion: a Step for High Satisfaction
Status: COMPLETED
Conditions: Intrauterine Device
Interventions: DEVICE: Intrauterine device|RADIATION: Ultrasound|PROCEDURE: uterine sounding sparing technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immunoadsorption of LPS, C5a and IL-6 in Severe Sepsis and Septic Shock (ISASS-1)
Status: COMPLETED
Conditions: Septicemia
Interventions: PROCEDURE: Immunoadsorption of LPS, IL-6 and C5a
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Vibrations on the Biceps Brachii Muscle and Grip Strength
Status: COMPLETED
Conditions: Muscle Strength
Interventions: OTHER: Vibration training with 42 Hz|OTHER: Vibration training with 63 Hz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate Effect of Pandel Cream 0.1% on HPA Axis in Pediatric and Adult Population
Status: COMPLETED
Conditions: Psoriasis|Atopic Dermatitis
Interventions: DRUG: Pandel Cream 0.1%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Cortisol Administration on Neural Correlates of Emotion in Depression
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Hydrocortisone acetate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: S-ketamine Prevents Postoperative Pain and Cognitive Dysfunction After Tibial Fracture
Status: UNKNOWN
Conditions: Postoperative Pain|Postoperative Cognitive Dysfunction
Interventions: DRUG: Normal saline|DRUG: S-ketamine (low-dose)|DRUG: S-ketamine (high-dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of the Manageability and Safety of ADBLOCK Adhesion Barrier System in Laparoscopic Gynaecological Surgery
Status: COMPLETED
Conditions: UTERINE MYOMAS
Interventions: DEVICE: ADBLOCK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Clinic Trial for West China Perioperative Transfusion Score (WCPTS)
Status: COMPLETED
Conditions: Transfusion Related Complications
Interventions: OTHER: Transfusion trigger based on WCPTS|OTHER: Maintenance of hemoglobin level more than 10g/dL|OTHER: Transfusion trigger based on experience
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Exposure to Substances Prohibited by the World Anti-Doping Agency in Healthy Volunteers.
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Bupropion|DRUG: Anastrozole|DRUG: Testosterone cyclopentylpropionate|DRUG: Danazol|DRUG: Chlorthalidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Acute Heart Failure - COngestion Repeated Evaluation (AHF-CORE)
Status: RECRUITING
Conditions: Acute Heart Failure
Interventions: PROCEDURE: Clinical examination centered on congestion|PROCEDURE: Cardio-pulmonary and peritoneal ultrasound|BIOLOGICAL: Blood sample retrieved for biological assessment and biobanking|OTHER: Telephone interview|BIOLOGICAL: Urinary sample retrieved for biological assessment and biobanking|PROCEDURE: jugular and renal ultrasound (optional)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Screening and Diagnosing Exercise-induced Bronchoconstriction in Recreational Young Athletes (12-18 y)
Status: COMPLETED
Conditions: Young Athletes|Biomarker|Exercise Induced Bronchoconstriction|Adolescent
Interventions: DIAGNOSTIC_TEST: EVH test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effects of Breathing Exercises on Fear of COVID-19, Anxiety, Sleep and Quality of Life During the COVID-19 Pandemic
Status: COMPLETED
Conditions: Healthy Adults
Interventions: OTHER: Breathing Exercises|OTHER: Information on COVID-19
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AZD9833 China PK Study
Status: COMPLETED
Conditions: ER+, HER2-, Metastatic Breast Cancer
Interventions: DRUG: AZD9833|DRUG: AZD9833|DRUG: AZD9833 with palbociclib|DRUG: AZD9833 with everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Nitric Oxide (INO) In Hypoxic Respiratory Failure
Status: WITHDRAWN
Conditions: Hypoxic Respiratory Failure With Pulmonary Hypertension
Interventions: DRUG: Inhaled Nitric Oxide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Lung Volume on Upper Airway Patency During Drug Induced Sleep Endoscopy
Status: RECRUITING
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Negative Pressure Ventilator|DEVICE: Pulmonary Function Testing (PFT)|DEVICE: Transcutaneous Phrenic Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Neoadjuvant Radiation on Tumor Infiltrating T-cells by Low Dose Radiation in Colorectal Liver Metastases
Status: UNKNOWN
Conditions: Colorectal Liver Metastases
Interventions: RADIATION: one time radiation|RADIATION: No Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Coronary Slow Flow or No-Reflow During EPCI in Patients With Acute STEMI
Status: UNKNOWN
Conditions: ST Segment Elevation Myocardial Infarction|Elective Percutaneous Coronary Intervention
Interventions: DRUG: Nitroprusside Sodium|DRUG: Tirofiban Hydrochloride|DRUG: Heparinized saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Pharmacodynamic Noninferiority of Efgartigimod PH20 SC Administered Subcutaneously as Compared to Efgartigimod Administered Intravenously in Patients With Generalized Myasthenia Gravis
Status: COMPLETED
Conditions: Generalized Myasthenia Gravis
Interventions: BIOLOGICAL: efgartigimod PH20 SC|BIOLOGICAL: efgartigimod IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain and Safety of Restylane Perlane With and Without Lidocaine for Correction of Moderate and Severe Nasolabial Folds
Status: COMPLETED
Conditions: Nasolabial Fold
Interventions: DEVICE: Restylane Perlane Lidocaine|DEVICE: Restylane Perlane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn How the Study Treatment BAY3283142 Taken as Single Dose by Mouth Moves Into, Through, and Out of the Body, How Safe it is, and How it Affects the Body in Participants With Reduced Kidney Function Compared to Participants With Normal Kidney Function of Similar Age, Gender, and Weight
Status: COMPLETED
Conditions: Chronic Kidney Disease|Renal Impairment|Healthy Volunteers
Interventions: DRUG: Single oral dose of BAY3283142 IR (immediate release) tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IPT of Malaria With SP in Different Zones of Drug Resistance in Rwanda
Status: COMPLETED
Conditions: Non HIV Infected Pregnant Women
Interventions: DRUG: Sulfadoxine-Pyrimethamine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Rybelsus (Semaglutide) Among Adults With Alcohol Use Disorder (AUD)
Status: RECRUITING
Conditions: Alcohol Use Disorder
Interventions: DRUG: Semaglutide 3 MG [Rybelsus]|DRUG: Semaglutide 7 MG [Rybelsus]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Agreement and Precision Study of the Nidek Mirante
Status: COMPLETED
Conditions: Glaucoma|Retinal Disease|Corneal Disease
Interventions: DEVICE: Nidek Mirante|DEVICE: Optovue RTVue XR Avanti|DEVICE: Optos P200DTx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Relative Bioavailability of a BI 187004 Tablet Formulation in Comparison With an Oral Solution and the Influence of Food on the Tablet Formulation in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 187004|DRUG: BI 187004|DRUG: BI 187004
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Primary Umbilical Hernia Repair With Routine Defect Closure Using Su2ura Approximation Device
Status: RECRUITING
Conditions: Primary Umbilical Hernia
Interventions: DEVICE: Su2ura Approximation Device|PROCEDURE: Laparoscopic hernia repair surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Fluticasone Furoate/ Umeclidinium/ Vilanterol (FF/UMEC/VI) Using the Connected Inhaler System (CIS) as Compared With Fluticasone Proprionate/ Salmeterol (FP/SAL) Plus Tiotropium (TIO) in Inadequately Controlled Asthma
Status: WITHDRAWN
Conditions: Asthma
Interventions: DRUG: FF/UMEC/VI|DRUG: FP/SAL|DRUG: Tiotropium|DRUG: Albuterol/salbutamol|DEVICE: ELLIPTA DPI|DEVICE: DISKUS DPI|DEVICE: RESPIMAT inhaler|DEVICE: Metered Dose Inhaler|DEVICE: Connected Inhaler System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Susceptibility to Infectious Diseases in obEsity: an endocRine trAnslational socioLogic Evaluation, "SIDERALE"
Status: RECRUITING
Conditions: Obesity|Type2diabetes|Lipodystrophy|Infections|Obesity Associated Disorder
Interventions: DIETARY_SUPPLEMENT: Mediterranean diet|DIETARY_SUPPLEMENT: Melatonin supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Dietary Fibre Consumption on Digestive Comfort
Status: RECRUITING
Conditions: Gastrointestinal Discomfort
Interventions: DIETARY_SUPPLEMENT: Soluble corn fibre|DIETARY_SUPPLEMENT: Inulin|DIETARY_SUPPLEMENT: soluble corn fibre and inulin|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Paclitaxel in Patients With Metastatic or Advanced Gastrointestinal Stromal Tumors (GIST) After Failure to Imatinib and Sunitinib
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumors
Interventions: DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Safety and Tolerability of Nutrifriend Cachexia in NSCLC Cachexia
Status: COMPLETED
Conditions: Cachexia|NSCLC
Interventions: DIETARY_SUPPLEMENT: Nutrifriend Cachexia|DIETARY_SUPPLEMENT: Isocaloric placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Chewing Gum on Abdominal Distension in Patients After Lumbar Spine Surgery
Status: COMPLETED
Conditions: Lumbar Spondylosis
Interventions: PROCEDURE: Gum chewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Outcome in Schizophrenia Through Identification of Genetic Risk Factors
Status: RECRUITING
Conditions: Schizophrenia|Schizoaffective Disorder|Bipolar Disorder|Major Depression
Interventions: PROCEDURE: genetic analysis|PROCEDURE: genetic assay
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Use of a High-frequency Ultrasonic Knife in Breast Cancer Surgery
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: ultrasonic knife (Ultracision®, Ethicon Endo Surgery)|PROCEDURE: conventional diarthermy knife
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparing Two Types of Sedation to Gynaecological Patients
Status: COMPLETED
Conditions: Transcervical Resection of Endometrium|Transcervical Resection of Fibroids|Transcervical Resection of Polyp
Interventions: DRUG: Remifentanil, propofol and citanest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Resistance Training in Patients With Diabetic Neuropathy
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Polyneuropathy Diabetes|Diabetes Complications|Diabetic Peripheral Neuropathy|Muscle Weakness|Fall Patients
Interventions: OTHER: 12-week resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Vancomycin Versus Daptomycin for the Treatment of Methicillin-resistant Staphylococcus Aureus Bacteremia Due to Isolates With High Vancomycin Minimum Inhibitory Concentrations (MICs)
Status: TERMINATED
Conditions: Bacteremia
Interventions: DRUG: Vancomycin|DRUG: Daptomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prednisolone Addition for Patients With Recent-onset Psychotic Disorder
Status: TERMINATED
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder|Psychotic Disorder NOS
Interventions: DRUG: Prednisolone|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Maxy-G34 in Breast Cancer Patients Treated With TAC (Docetaxel, Adriamycin, Cyclophosphamide) Chemotherapy
Status: UNKNOWN
Conditions: Chemotherapy-Induced Neutropenia|Breast Cancer
Interventions: BIOLOGICAL: Maxy-G34
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Atezolizumab + Bevacizumab in Endometrial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Cancer
Interventions: DRUG: Bevacizumab|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2b Study of Baricitinib in Participants With Moderate to Severe Psoriasis
Status: COMPLETED
Conditions: Psoriasis|Skin Diseases|Skin Diseases, Papulosquamous
Interventions: DRUG: Placebo|DRUG: Baricitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Discovering New Treatments for Asthma and COPD. A New Human Rhinvovirus for Human Challenge
Status: COMPLETED
Conditions: Rhinovirus
Interventions: OTHER: Titre 1|OTHER: Titre 2|OTHER: Titre 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Remote Monitoring in Preschool Wheeze
Status: UNKNOWN
Conditions: Wheezing|Respiratory Sounds
Interventions: DEVICE: Lung function monitoring equipment at home - 2 weeks|DEVICE: Lung function monitoring equipment at home - 4 months|DIAGNOSTIC_TEST: Inflammation and remodelling from clinical indicted bronchoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Gemzar (Gemcitabine) and Alimta (Pemetrexed) in the Treatment of Patients With Recurrent Platinum-Sensitive and Platinum-Resistant Ovarian or Peritoneal Cancer
Status: TERMINATED
Conditions: Ovarian Cancer|Peritoneal Cancer
Interventions: DRUG: Gemzar and Alimta
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Keratinocyte Growth Factor- Hair Serum for the Prevention of Chemotherapy Induced Alopecia
Status: COMPLETED
Conditions: Alopecia|Chemotherapy-Induced Change|Hair Loss|Alopecia Drugs
Interventions: DRUG: Keratinocyte growth factor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Rosuvastatin on Systemic Sclerosis-related Pulmonary Hypertension
Status: COMPLETED
Conditions: Systemic Sclerosis
Interventions: DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Avatrombopag Combined With IST for the Treatment of HAAA and SAA With Abnormal Liver Function
Status: UNKNOWN
Conditions: Aplastic Anemia
Interventions: DRUG: Avatrombopag 20 MG Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotic and Influenza Vaccination to Reducing Influenza-like Illness Incident in Elderly
Status: COMPLETED
Conditions: Influenza-like Illness
Interventions: BIOLOGICAL: Flubio|DIETARY_SUPPLEMENT: Lacidofil|OTHER: Placebo Vaccine|OTHER: Placebo probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Study of Three Different Formulations of Omega-3 (EPA+DHA)
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DIETARY_SUPPLEMENT: MAG-EPA/MAG-DHA|DIETARY_SUPPLEMENT: TG-EPA/TG-DHA|DIETARY_SUPPLEMENT: EE-EPA/EE-DHA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma|Myeloma|Myeloma Multiple
Interventions: DRUG: KTX-1001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Diaphragm Manual Therapy Verses Sustained Natural Apophyseal Glide in Mechanical Neck Pain
Status: NOT_YET_RECRUITING
Conditions: Neck Pain
Interventions: OTHER: Baseline treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Host Responses in Kidney-transplant Recipients With Chronic Hepatitis E Virus Infection
Status: COMPLETED
Conditions: Kidney-transplant Recipients With Chronic Hepatitis E Virus Infection
Interventions: OTHER: blood samples|OTHER: blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Diabetes Virus Detection Project, Intervention With GAD-alum
Status: TERMINATED
Conditions: Diabetes, Type I|Enterovirus Infections|Autoimmunity
Interventions: DRUG: GAD-alum|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vestibular Precision: Physiology & Pathophysiology
Status: ENROLLING_BY_INVITATION
Conditions: Vestibular Schwannoma|Inner Ear Disease|Dizziness|Neurofibromatosis 2|Vestibular Disorder
Interventions: BEHAVIORAL: VOR precision training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of 3M Cavilon Advanced Skin Protectant in the Management of Damaged Skin Around an Ostomy, Drain or Fistula
Status: TERMINATED
Conditions: Ostomy
Interventions: DEVICE: Cavilon Advanced Skin Protectant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Multi-intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Heart Failure With Reduced Ejection Fraction（PRIME-HFrEF Study）
Status: COMPLETED
Conditions: Heart Failure, Systolic
Interventions: BIOLOGICAL: human umbilical cord mesenchymal stem cells|OTHER: human serum albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of 0.5% and 2.5% Cis-UCA Eye Drops in Adult Healthy Volunteers (Phase I)
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: cis-urocanic acid 0,5% eye drops|DRUG: cis-urocanic acid 2.5% eye drops|DRUG: Placebo for cis-UCA, eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remote Ischemic Conditioning in Traumatic Brain Injury
Status: UNKNOWN
Conditions: Traumatic Brain Injury|Brain Injuries|Brain Trauma|Brain Injuries, Traumatic
Interventions: DEVICE: Remote Ischemic Conditioning|OTHER: No-Remote Ischemic Conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Danish Population-based Assessment of Psoriasis and Psoriatic Arthritis (DANPAPP)
Status: UNKNOWN
Conditions: Psoriasis|Psoriatic Arthritis
Interventions: DRUG: Apremilast Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Improving Sleep to Reduce Risk for Substance Use Disorder
Status: COMPLETED
Conditions: Substance Use Disorders|Insomnia|Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Brief Behavioral Therapy for Insomnia|BEHAVIORAL: Repeated Contact
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Detection and Prevention of Cancer-Related Cardiovascular Toxicity Registry
Status: NOT_YET_RECRUITING
Conditions: Cancer Related Cardiovascular Toxicity
Interventions: COMBINATION_PRODUCT: Prospective validation of the HFA-ICOS risk score in a subset of subjects with newly diagnosed breast cancer and undergoing treatment with anthracyclines analogues with or without radiotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Foam Rolling and Tissue Flossing of the Cuff Muscles
Status: COMPLETED
Conditions: Ankle Injuries|Ankle Sprains
Interventions: OTHER: Foam rolling|OTHER: Tissue flossing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Resilience and Brain Health of Older Adults During the COVID-19 Pandemic (MEDEX-2)
Status: ENROLLING_BY_INVITATION
Conditions: Age-related Cognitive Decline
Interventions: BEHAVIORAL: Mindfulness-Based Stress Reduction|BEHAVIORAL: Exercise|BEHAVIORAL: Mindfulness-Based Stress Reduction + Exercise|BEHAVIORAL: Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Sugammadex With Neostigmine During Laparoscopic Cholecystectomy or Appendectomy (P05699)
Status: COMPLETED
Conditions: Anesthesia, General
Interventions: DRUG: Rocuronium|DRUG: Sugammadex|DRUG: Neostigmine|DRUG: Atropine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of SCG101 in the Treatment of Subjects With Hepatitis B Virus-Related Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatitis B Virus Related Hepatocellular Carcinoma|Hepatocellular Carcinoma Recurrent
Interventions: BIOLOGICAL: SCG101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SGI-110 in Combination With Carboplatin in Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: SGI-110|DRUG: Treatment of Choice (topotecan, pegylated liposomal doxorubicin, paclitaxel, or gemcitabine)|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thorough QT Study to Evaluate Ampreloxetine in Healthy Subjects
Status: COMPLETED
Conditions: Symptomatic Neurogenic Orthostatic Hypertension|nOH
Interventions: DRUG: Ampreloxetine <Dose A>|DRUG: Ampreloxetine <Dose B>|DRUG: Ampreloxetine Placebo|DRUG: Moxifloxacin|DRUG: Moxifloxacin Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen
Status: COMPLETED
Conditions: Analgesia
Interventions: DRUG: HTX-011|DRUG: Ibuprofen|DRUG: Acetaminophen|DRUG: Celecoxib|DRUG: +/- Bupivacaine HCl|DEVICE: Luer Lock Applicator|DRUG: HTX-011
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ipilimumab Induction in Patients With Melanoma Brain Metastases Receiving Stereotactic Radiosurgery
Status: TERMINATED
Conditions: Metastatic Melanoma|Brain Metastases
Interventions: DRUG: Ipilimumab|PROCEDURE: Stereotactic Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can a Nasal Decongestant Test Predict Treatment Outcomes in Seasonal Allergic Rhinitis?
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: mometasone furoate nasal spray|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Study of TMC435 Plus Pegylated Interferon Alfa-2a and Ribavirin in Participants With Chronic HCV Infection
Status: COMPLETED
Conditions: Hepatitis C, Chronic|Infection
Interventions: DRUG: TMC435|DRUG: Pegylated interferon alfa-2a (PegIFNα-2a)|DRUG: Ribavirin (RBV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulse Photoplethysmography as an Early Tool for the Diagnosis of Sepsis
Status: COMPLETED
Conditions: Sepsis
Interventions: DEVICE: pulse photoplethysmography (PPG)|DIAGNOSTIC_TEST: Measurements of nitric oxide (NO) and malondialdehyde (MDA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exploring the Role of Adipocyte Fatty Acid Binding Protein in the Association of Obstructive Sleep Apnea and Metabolic Dysfunction
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Insulin Resistance|Metabolic Syndrome|Inflammation
Interventions: DEVICE: continuous positive airway pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Study of Solifenacin Succinate and Tamsulosin Hydrochloride Oral Controlled Absorption System (OCAS) in Males With Lower Urinary Tract Symptoms
Status: COMPLETED
Conditions: Lower Urinary Tract Symptoms|Benign Prostatic Hyperplasia
Interventions: DRUG: tamsulosin hydrochloride/solifenacin succinate fixed dose combination (0.4 mg/6 mg)|DRUG: tamsulosin hydrochloride/solifenacin succinate fixed dose combination (0.4 mg/9 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Lactobacillus GG With Diosmectite in Treatment Children With Acute Gastroenteritis
Status: COMPLETED
Conditions: Diarrhea
Interventions: DIETARY_SUPPLEMENT: Smectite|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Lactobacillus GG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Multicomponent Cognitive Intervention in Adults With Subjective Cognitive Decline and Mild Cognitive Impairments
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Subjective Cognitive Decline
Interventions: BEHAVIORAL: multicomponent cognitive intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CGM Use in Adults With Type 2 Diabetes on Basal Insulin
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DEVICE: FreeStyle Libre 3 Continuous Glucose Monitoring System.|DEVICE: Self monitoring of blood glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of a Single RTX-GRT7039 and Placebo Intra-articular Injection for Pain Associated With Osteoarthritis of the Knee
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis
Interventions: DRUG: RTX-GRT7039|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT