pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms
Status: RECRUITING
Conditions: Central Nervous System Neoplasms|Glioblastoma|Gliosarcoma, Adult|Anaplastic Oligodendroglioma|Anaplastic Astrocytoma|Pilocytic Astrocytoma|Oligodendroglioma|Gliomatosis Cerebri|Pleomorphic Xanthoastrocytoma|Anaplastic Pleomorphic Xanthoastrocytoma|Diffuse Midline Glioma, H3 K27M-Mutant|Ependymoma|Ependymoma, Anaplastic|Medulloblastoma|Teratoid Rhabdoid Tumor|Neuroectodermal Tumors, Primitive|Neuroectodermal Tumors|Anaplastic Meningioma|Atypical Meningioma|Choroid Plexus Neoplasms|Pineal Tumor|Diffuse Astrocytoma|Glial Tumor
Interventions: DRUG: ONC206
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of an Online ACT Intervention on Meaning-Making Process in Cancer Patients Following Hematopoietic Cell Transplantation
Status: RECRUITING
Conditions: Hematopoietic Cell Transplantation Recipient|Acceptance and Commitment Therapy
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy|BEHAVIORAL: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Foam Roller Applied to the SCM Muscle on Respiratory Muscle Fatigue
Status: RECRUITING
Conditions: Healthy Adults|Inspiratory Muscle Training
Interventions: DEVICE: Foam roller|DEVICE: Inspiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Immunogenicity and Safety Study of GSKs Recombinant Zoster Vaccine Shingrix (GSK1437173A) in Chinese Adults Aged ≥50 Years
Status: COMPLETED
Conditions: Herpes Zoster
Interventions: BIOLOGICAL: RZV|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Luspatercept With or Without Hydroxyurea for the Treatment of Myelodysplastic/Myeloproliferative Neoplasms With Ring Sideroblasts and Thrombocytosis or Unclassifiable With Ring Sideroblasts
Status: TERMINATED
Conditions: Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis, Not Otherwise Specified|Myelodysplastic/Myeloproliferative Neoplasm, Not Otherwise Specified
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|DRUG: Hydroxyurea|BIOLOGICAL: Luspatercept|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Performance of ESTYME® MATRIX Round and Anatomical Breast Implants - EMMIE Study
Status: UNKNOWN
Conditions: Breast Augmentation|Breast Reconstruction
Interventions: DEVICE: ESTYME® MATRIX Breast Implants
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plantar Plate Repair for Treatment of Floating Toe: Must we Associate it to Weil Osteotomy?
Status: RECRUITING
Conditions: Floating Toe
Interventions: PROCEDURE: Weil osteotomy|PROCEDURE: Plantar plate repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Watercress Intake Have an Impact on Cancer Patients Outcomes: a Longitudinal Trial
Status: UNKNOWN
Conditions: Long-term Effects Secondary to Cancer Therapy in Adults
Interventions: DIETARY_SUPPLEMENT: Watercress
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Targeted Marrow Irradiation, Fludarabine Phosphate, and Busulfan Before Donor Progenitor Cell Transplant in Treating Patients With Hematologic Malignancies
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Hematologic Malignancies|Acute Lymphocytic Leukemia|Non Hodgkin Lymphoma|Hodgkin Lymphoma|Multiple Myeloma|Myelodysplastic Syndrome|Chronic Lymphocytic Leukemia|Chronic Myeloid Leukemia|Myelofibrosis|Myeloproliferative Syndrome
Interventions: RADIATION: total marrow irradiation|DRUG: fludarabine phosphate|DRUG: busulfan|PROCEDURE: myeloid progenitor cell transplantation|BIOLOGICAL: anti-thymocyte globulin|DRUG: tacrolimus|DRUG: methotrexate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ENHANCED RECOVERY AFTER BILIARY TRACT SURGERY
Status: UNKNOWN
Conditions: Biliary Stricture|Cholangiocarcinoma|Cholangitis; Choledocholithiasis
Interventions: COMBINATION_PRODUCT: Enhanced recovery after biliary tract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Eflornithine for Pseudofolliculitis Barbae: Randomized Controlled Trial
Status: TERMINATED
Conditions: Pseudofolliculitis Barbae
Interventions: DRUG: Eflornithine Topical|DRUG: Placebo Eflornithine Topical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Discontinuation of Cholinesterase Inhibitors for the Treatment of Severe Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease|Dementia
Interventions: DRUG: Cholinesterase Inhibitor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interventional Reference Levels (IRL) in Digestive Endoscopy
Status: NOT_YET_RECRUITING
Conditions: Each Endoscopic Intervention Using X-rays
Interventions: PROCEDURE: ERCP|PROCEDURE: endoscopic ultrasound|PROCEDURE: gastroscopy|PROCEDURE: Colonoscopy|PROCEDURE: placement of a nasojejunal tube
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multi-Center Comparison of Dual Lumen Versus Single Lumen Ureteroscopes
Status: UNKNOWN
Conditions: Urolithiasis
Interventions: DEVICE: Storz single Lumen Ureteroscope|DEVICE: Dual Lumen Ureteroscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas
Status: UNKNOWN
Conditions: Sarcoma|Osteoid Sarcoma|Ewing Sarcoma
Interventions: BIOLOGICAL: Sarcoma-specific CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognition Evolution and MRI Markers in PPMS Patients on 2 Years
Status: RECRUITING
Conditions: Multiple Sclerosis, Primary Progressive
Interventions: OTHER: Clinical assessment|OTHER: Ecological evaluation|OTHER: Neuropsychological evaluation|OTHER: Psychological evaluation|DEVICE: MRI Evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Investigating Proximal Migration in Trabecular Metal Cups Used In Acetabular Revision Surgery
Status: COMPLETED
Conditions: Prosthesis Loosening
Interventions: DEVICE: Trilogy cup|DEVICE: Trabecular metal cup (TM)|DEVICE: ZCA cup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Patient Warming for Prevention of Perioperative Hypothermia in Major Abdominal Surgery
Status: COMPLETED
Conditions: Preoperative Warming|Prewarming|Perioperative Hypothermia|General Anaesthesia|Epidural Anaesthesia|Temperature Monitoring
Interventions: DEVICE: Forced-air warming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spinal Cord Stimulation for Functional Recovery in Humans With Tetraplegia
Status: RECRUITING
Conditions: Spinal Cord Injury
Interventions: DEVICE: TESS|OTHER: Training|OTHER: Motor Task|DEVICE: sham-TESS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Real-World Effectiveness of Bevacizumab Based on AURELIA in Platinum-resistant Recurrent Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Weekly paclitaxel|DRUG: Topotecan|DRUG: Pegylated liposomal doxorubicin|DRUG: Bevacizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Efficacy Study of MORAb-009 (Amatuximab) in Subjects With Pleural Mesothelioma
Status: COMPLETED
Conditions: Malignant Pleural Mesothelioma
Interventions: DRUG: MORAb-009 (Amatuximab)|DRUG: Pemetrexed|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Evaluating Efficacy and Safety of Bevacizumab (Avastin®/Zeribev®) in Patients With COVID-19 Infection, Nested in the Corimmuno-19 Cohort
Status: UNKNOWN
Conditions: COVID19 Pneumonia
Interventions: DRUG: Bevacizumab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Hormone Patterns and Ovarian Follicular Activity With DR-1021
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: DR-1021|DRUG: Mircette®|DRUG: Kariva®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine and Cisplatin in Treating Patients With Refractory or Recurrent Cancer of the Cervix
Status: TERMINATED
Conditions: Cervical Cancer
Interventions: DRUG: cisplatin|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effects of Fermented Milk Product Enriched With Plant Sterols and Policosanols in Mild Hypercholesterolaemic Adults
Status: COMPLETED
Conditions: Mildly Hypercholesterolemic Subjects
Interventions: OTHER: 1- Low fat drinkable fermented dairy product enriched with 1.6g of plant sterol (as free equivalent) + 10 mg of policosanols per unit|OTHER: 2- Low fat drinkable fermented dairy product enriched with 1.6g of plant sterol (as free equivalent) + 20 mg of policosanols per unit|OTHER: 3- Low fat drinkable fermented dairy product with 1.6g of plant sterol (as free equivalent) but without policosanols (Active control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Patient-Controlled Epidural Analgesia (PCEA) for Patients Who Have Had Major Open Gynecologic Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: patient-controlled epidural analgesia (PCEA)|DRUG: patient-controlled intravenous analgesia (PCA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted Therapy Using Intradermal Injection of Etanercept for Remission Induction in Discoid Lupus Erythematosus
Status: COMPLETED
Conditions: Lupus Erythematosus, Discoid|Lupus Erythematosus, Cutaneous|Lupus Erythematosus, Chronic Cutaneous
Interventions: DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Transcranial Direct Current Stimulation on Tobacco Withdrawal Symptoms
Status: COMPLETED
Conditions: Nicotine Withdrawal|Tobacco Abstinence
Interventions: DEVICE: tDCS, prefrontal cortex and parietal cortex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Mixed-method Pilot Investigation of Paradoxical Intention for Insomnia.
Status: NOT_YET_RECRUITING
Conditions: Insomnia|Comorbidities and Coexisting Conditions
Interventions: BEHAVIORAL: Paradoxical Intention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial for Zebinix (Eslicarbazepine Acetate) in Healthy Korean and Caucasian Adult
Status: COMPLETED
Conditions: Partial-onset Seizures With or Without Secondary Generalisation
Interventions: DRUG: Zebinix 400mg|DRUG: Placebo for Zebinix 400mg|DRUG: Zebinix 800mg|DRUG: Placebo for Zebinix 800mg|DRUG: Zebinix 1600mg|DRUG: Placebo for Zebinix 1600mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomised, Assessor-Blind, Comparative Efficacy Clinical Trial of 3 Pediculicides.
Status: COMPLETED
Conditions: Pediculosis
Interventions: DRUG: 1) MOOV Head Lice Treatment (Ego Pharmaceutical).|DRUG: Banlice Mousse Aerosol (Pfizer, Australia)|DRUG: 3) KP24 Medicated Foam (Nelson Laboratories)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Ixazomib Citrate in Treating Patients With Relapsed Multiple Myeloma That Is Not Refractory to Bortezomib
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: DRUG: Cyclophosphamide|BIOLOGICAL: Daratumumab|DRUG: Dexamethasone|DRUG: Ixazomib Citrate|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnosis-related Outcomes in NeurocriTical Care: Prognostic Estimate by Health-care Providers Versus Risk Scores in Intracerebral and Subarachnoid Hemorrhage
Status: RECRUITING
Conditions: Intracerebral Hemorrhage|Subarachnoid Hemorrhage
Interventions: OTHER: none, only assessment at different time points
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Do Bisphosphonates Alter the Skeletal Response to Mechanical Stimulation in Children With Osteogenesis Imperfecta?
Status: COMPLETED
Conditions: Osteogenesis Imperfecta
Interventions: DRUG: Risedronate Sodium|DIETARY_SUPPLEMENT: Calcichew tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Alternating Bidirectional Versus The Standard Approach During Shock Wave Lithotripsy For Renal And Upper Lumbar Ureteric Stones
Status: UNKNOWN
Conditions: Urologic Diseases|Stones, Kidney|Stone, Urinary|Shock Wave Lithotripsy
Interventions: PROCEDURE: Bidirectional Shock Wave Lithotripsy|PROCEDURE: Standard Shock Wave Lithotripsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Three Technical Airway Clearance in Mechanical Ventilated Patients
Status: COMPLETED
Conditions: Mucociliary Clearance Defect|Physical Disability
Interventions: OTHER: Vibrocompression (VB)|OTHER: Hyperinflation (HMV)|OTHER: HMV+VB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Imaging-Guided Laser Induced Thermal Therapy for Treatment of Metastatic Brain Tumors
Status: UNKNOWN
Conditions: Brain Neoplasms
Interventions: DEVICE: MRI-Guided Laser Induced Thermal Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of MGCD0103 (MG-0103) in Patients With Relapsed or Refractory Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Hodgkin's Lymphoma
Interventions: DRUG: MGCD0103
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Web-based Patient Education Program to Manage Side Effects of Allogeneic Stem Cell Transplant
Status: WITHDRAWN
Conditions: Allo-SCT Patients|Adult Allo-SCT Survivor
Interventions: OTHER: web-based patient education|BEHAVIORAL: questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Upadacitinib|DRUG: Dupilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Benefit of M89PB in Subjects With Rosacea Associated With Erythema and Sensitive Skin
Status: UNKNOWN
Conditions: Rosacea|Sensitive Skin
Interventions: OTHER: Mineral 89 Probiotic Fractions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of NMBA on Surgical Conditions in THR
Status: WITHDRAWN
Conditions: Surgery|Postoperative Pain
Interventions: DRUG: Rocuronium|DRUG: Sugammadex|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Arthroscopic vs. Open Bone Grafting for Scaphoid Delayed/Nonunion
Status: RECRUITING
Conditions: Scaphoid Fracture|Scaphoid Nonunion
Interventions: PROCEDURE: Graft reconstruction and internal fixation with compression screw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate After Irinotecan and Cisplatin in Treating Patients With Extensive-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Cisplatin|DRUG: Gleevec™|DRUG: irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-PD-L1/TGF-beta Trap (M7824) Alone and in Combination With TriAd Vaccine and N-803 for Resectable Head and Neck Squamous Cell Carcinoma Not Associated With Human Papillomavirus Infection
Status: COMPLETED
Conditions: Head and Neck Cancer|Head and Neck Neoplasms
Interventions: DRUG: M7824|DRUG: N803|BIOLOGICAL: TriAd vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Patient Experience During Myocardial Perfusion Imaging
Status: ACTIVE_NOT_RECRUITING
Conditions: Myocardial Ischemia|Myocardial Infarction|Autonomic Dysfunction
Interventions: OTHER: Care as usual with information support|OTHER: Care as usual with supportive coaching|OTHER: Care as usual with information support and supportive coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate Direct Wire Pacing (DWP) for Measuring Fractional Flow Reserve (FFR)
Status: COMPLETED
Conditions: Coronary Artery Stenosis|Fractional Flow Reserve
Interventions: DIAGNOSTIC_TEST: FFR DWP|DIAGNOSTIC_TEST: FFR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: An Efficacy, Safety, and Tolerability Study of TMC435 in Treatment-naive, Genotype 1 Hepatitis C-infected Patients
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Placebo|DRUG: TMC435|DRUG: Peginterferon alpha-2a (PegIFN alpha-2a)|DRUG: Ribavirin (RBV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Efficacy of Hyaluronic Acid Injection in Labia Majora Augmentation
Status: RECRUITING
Conditions: Vulvar Atrophy
Interventions: DEVICE: Experimental- Genefill Contour®|DEVICE: Marketed comparator - Desirial®Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA Vaccine Candidate Variations in Healthy Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: mRNA-1010|BIOLOGICAL: mRNA-1010.4|BIOLOGICAL: mRNA-1010.6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ischemic Post-conditioning in Acute Ischemic Stroke Thrombectomy (PROTECT-1b)
Status: RECRUITING
Conditions: Acute Ischemic Stroke|Reperfusion Injury
Interventions: PROCEDURE: Mechanical thrombectomy combined with ischemic post-conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Insole-based Visual Biofeedback for Weight-bearing in Total Hip Replacement
Status: COMPLETED
Conditions: Total Hip Replacement|Visual Biofeedback|Weight Bearing
Interventions: DEVICE: Visual biofeedback with the use of sensorized insoles|OTHER: Standard rehabilitation based on physiotherapist's verbal instructions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Pharmacokinetics (PK) of Triptorelin 6-month Formulation in Patients With Central Precocious Puberty
Status: COMPLETED
Conditions: Central Precocious Puberty
Interventions: DRUG: Triptorelin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trials Evaluating the Effect of Metformin Treatment on Function Endometrium in Women Diagnosed With Idiopathic Infertility
Status: NOT_YET_RECRUITING
Conditions: Infertility, Female
Interventions: DRUG: Metformin Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Pharmacodynamics of CHI-914 in Healthy Participants
Status: RECRUITING
Conditions: Behavioral Pharmacology of Cannabis
Interventions: DRUG: Oral Placebo|DRUG: Oral CBG Cannabis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trastuzumab Combined With Chemotherapy or Endocrine Therapy to Treat Metastatic Luminal B2 Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Endocrine therapy combined with trastuzumab|DRUG: Chemotherapy combined with trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Ultrasound Guided Colorectal ESD and Traditional Colorectal ESD Surgery
Status: RECRUITING
Conditions: Colorectal Endoscopic Submucosal Dissection(ESD) Surgery
Interventions: PROCEDURE: endoscopic ultrasound guided colorectal ESD surgery|PROCEDURE: the traditional colorectal ESD surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Two Training Methods for Opioid Wizard
Status: COMPLETED
Conditions: Opioid-use Disorder|Opioid Dependence|Attitude of Health Personnel
Interventions: BEHAVIORAL: Online training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Testing the Addition of an Anti-cancer Drug, Pembrolizumab, to the Usual Intravesical Chemotherapy Treatment (Gemcitabine) for the Treatment of BCG-Unresponsive Non-muscle Invasive Bladder Cancer
Status: RECRUITING
Conditions: Bladder Urothelial Carcinoma In Situ|Invasive Bladder Mixed Carcinoma|Stage 0a Bladder Cancer AJCC v8|Stage 0is Bladder Cancer AJCC v8|Stage I Bladder Cancer AJCC v8
Interventions: DRUG: Gemcitabine Hydrochloride|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in the Treatment of Erectile Dysfunction and Benign Prostate Hyperplasia
Status: COMPLETED
Conditions: Erectile Dysfunction|Benign Prostatic Hyperplasia
Interventions: DRUG: Tadalafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Neuroprotection in Aneurysm Coiling Therapy
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: NA-1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Advanced Bone and Soft Tissue Tumors
Status: RECRUITING
Conditions: Osteosarcoma|Sarcoma|Soft Tissue Sarcoma|Bone Tumor
Interventions: DRUG: Recombinant oncolytic herpes simplex virus type Ⅰ (R130)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Precision Rehabilitation Approach to Counteract Age-Related Cognitive Declines
Status: TERMINATED
Conditions: Cognition Disorders|Brain Pathology|Physical Disability|Physical Activity|Aging
Interventions: BEHAVIORAL: Aerobic Activity|BEHAVIORAL: Resistance Training|BEHAVIORAL: Yoga|BEHAVIORAL: Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Controlled Human Exposure to Indoor Air, Dust and Ozone
Status: COMPLETED
Conditions: Subjective Discomfort|General Mucosal Irritation|Acute Changes in Respiratory Outcomes|Acute Changes in Cardiovascular Outcomes|Changes in Biomarkers
Interventions: DEVICE: Dust|DEVICE: Ozone|DEVICE: Dust and Ozone|DEVICE: Placebo (Filtered air)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Interventional Study on DEterminants and Factors of Physical ACtivity After Treatments in Oncology
Status: RECRUITING
Conditions: Breast Cancer|Colo-rectal Cancer|Lung Cancer|Prostate Cancer
Interventions: BEHAVIORAL: Physical activity program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Remission and Joint Damage Progression in Early Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Abatacept|DRUG: placebo|DRUG: methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ceftobiprole in the Treatment of Resistant Staphylococcus Aureus Skin and Skin Structure Infections
Status: COMPLETED
Conditions: Skin Diseases, Infectious|Skin Diseases, Bacterial|Staphylococcal Skin Infections
Interventions: DRUG: Ceftobiprole medocaril|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of SHR4640 and Febuxostat in Subjects With Hyperuricemia
Status: UNKNOWN
Conditions: Hyperuricemia
Interventions: DRUG: SHR4640 dose1 plus Febuxostat dose1|DRUG: SHR4640 dose1 plus Febuxostat dose2|DRUG: SHR4640 dose2 plus Febuxostat dose3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BABA Robotic Thyroidectomy Without Gas is Safe Enough as That Use a Gas
Status: COMPLETED
Conditions: Thyroidectomy|Thyroid Diseases
Interventions: PROCEDURE: Gasless BABA|PROCEDURE: Classic BABA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Immune Globulin Intravenous (Human) GC5107 in Subjects With Primary Humoral Immunodeficiency
Status: COMPLETED
Conditions: Immunologic Deficiency Syndromes
Interventions: BIOLOGICAL: GC5107
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Pre-dialysis Extension in Europe and Asia Pacific
Status: COMPLETED
Conditions: Anemia|Renal Insufficiency, Chronic
Interventions: DRUG: Molidustat (BAY85-3934)|BIOLOGICAL: Darbepoetin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Brodalumab Compared With Placebo in Subjects With Axial Spondyloarthritis
Status: WITHDRAWN
Conditions: Axial Spondyloarthritis
Interventions: DRUG: Brodalumab 210 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Low Molecular Weight Heparin Versus Dabigatran on Platelet Aggregation in Patients With Stable Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Disease
Interventions: DRUG: Dabigatran|DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maintenance Therapy With Anti-PD-1 Antibody for Patients With NK/T-cell Lymphoma
Status: UNKNOWN
Conditions: Extranodal NK/T-cell Lymphoma, Nasal Type
Interventions: DRUG: toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine vs. Azithromycin for Outpatients in Utah With COVID-19
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Hydroxychloroquine|DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of a Live Attenuated Virus Tetravalent Dengue Vaccine in Healthy Adults in Thailand
Status: COMPLETED
Conditions: Dengue
Interventions: BIOLOGICAL: T-DEN F17|BIOLOGICAL: T-DEN F-19|OTHER: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Subcapital and Shaft Fractures of the 5. Metacarpal
Status: TERMINATED
Conditions: Fracture
Interventions: PROCEDURE: Closed reduction and fixation with 2 pins|PROCEDURE: Reduction and Plaster of Paris
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Favipiravir 200 mg Film Tablet (Novelfarma, Turkey) Under Fasting Conditions
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: FAVIRA 200 MG Film Tablet|DRUG: AVIGAN 200 MG Film Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Mitoxantrone Hydrochloride Liposome Injection in the Treatment of Relapsed/Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Relapsed/Refractory Multiple Myeloma
Interventions: DRUG: Mitoxantrone hydrochloride liposome/Dexamethasone/daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolinapant and Radiation for Cisplatin-Ineligible, Previously Untreated, Locally Advanced Head and Neck Cancer
Status: RECRUITING
Conditions: Head and Neck Carcinoma of Unknown Primary|Locally Advanced Head and Neck Squamous Cell Carcinoma|Locally Advanced Hypopharyngeal Squamous Cell Carcinoma|Locally Advanced Laryngeal Squamous Cell Carcinoma|Locally Advanced Nasopharyngeal Squamous Cell Carcinoma|Locally Advanced Oropharyngeal Squamous Cell Carcinoma
Interventions: DRUG: Tolinapant|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Effectiveness and Safety of a New Higher 40mg Dose of Copaxone® Compared to Copaxone® 20mg, the Currently Approved Dose
Status: COMPLETED
Conditions: Relapse-Remitting Multiple Sclerosis
Interventions: DRUG: glatiramer acetate 20 mg|DRUG: glatiramer acetate 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Post-OP AFib Using Combination of CardiaMend and Amiodarone
Status: COMPLETED
Conditions: Post Operative Atrial Fibrillation
Interventions: COMBINATION_PRODUCT: CardiaMend with the Addition of Amiodarone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Role of the Coagulation Pathways in Recurrent Angioedema
Status: TERMINATED
Conditions: Chronic Spotaneous Urticaria, Idiopathic Non Histaminergic Angioderma, Hereditary Angioedema With C1 Inhibitor Deficiency
Interventions: OTHER: BLOOD TEST
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy Study of Ketamine for Postoperative Pain in Opioid Dependent Patients
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Ketamine|DRUG: Placebo|DRUG: Hydromorphone PCA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CO2-Angiography-Study to Evaluate Diagnostic and Safety to Patients With Peripher Arterial Stenotic or Occlusive Disease.
Status: COMPLETED
Conditions: Peripheral Arterial Occlusive Disease
Interventions: DEVICE: Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Lithium Carbonate in Patients With Spinocerebellar Ataxia Type 3
Status: COMPLETED
Conditions: Spinocerebellar Ataxia Type 3|Machado Joseph Disease
Interventions: DRUG: Lithium Carbonate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Online Training & Certification for Competency in Dementia Friendly Hospital Care
Status: UNKNOWN
Conditions: Knowledge, Attitudes, Practice|Burnout, Caregiver|Job Satisfaction
Interventions: BEHAVIORAL: CARES Dementia-Friendly Hospitals Online Training and Certification Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tagraxofusp in Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm or Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)|Acute Myeloid Leukemia (AML)
Interventions: DRUG: Tagraxofusp
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Trial in Hormone Withdrawal Associated Symptoms
Status: COMPLETED
Conditions: Oral Contraceptive
Interventions: DRUG: EE20/DRSP (YAZ, BAY86-5300)|DRUG: Ethinylestradiol (EE) and desogestrel (DSG) (Mercilon)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Povidone Iodine vs AVEnova: A Pre-injection Disinfection Study (PAVE Study)
Status: COMPLETED
Conditions: Age-related Macular Degeneration|Diabetic Retinopathy|Diabetic Macular Edema
Interventions: OTHER: Povidone Iodine|OTHER: Hypochlorous Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interaction Between Early Trauma and Odor-induced Dopamine Release
Status: NOT_YET_RECRUITING
Conditions: Trauma, Psychological
Interventions: OTHER: High score at Childhood Trauma Questionnaire.|OTHER: Low score at Childhood Trauma Questionnaire.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Electric Toothbrush Efficacy in Preventing Dental Plaque Development
Status: COMPLETED
Conditions: Dental Plaque|Calculus, Dental
Interventions: BEHAVIORAL: oscillating toothbrush|BEHAVIORAL: standard manual toothbrush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of S 95005 (TAS-102) in Patients With Metastatic Colorectal Cancer Who Failed Standard Chemotherapies
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: S95005
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of ID-Specific Donor Vaccinated Lymphocyte Infusion for Patients With Myeloma Relapsing or Failing to Achieve a Complete Remission After an Allogenic Transplant
Status: TERMINATED
Conditions: Myeloma
Interventions: BIOLOGICAL: KLH Vaccine|BIOLOGICAL: KLH-id Vaccine|DRUG: GM-CSF|PROCEDURE: Apheresis|PROCEDURE: Donor Lymphocyte Infusion (DLI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Roflumilast on Pulmonary Function and Respiratory Symptoms in Patients With Chronic Obstructive Pulmonary Disease (COPD) (BY217/M2-110)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|COPD
Interventions: DRUG: Roflumilast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Double Bypass Versus Stent-treatment in Irresectable Pancreatic Cancer
Status: WITHDRAWN
Conditions: Pancreatic Cancer|Periampullary Tumor
Interventions: PROCEDURE: Hepaticojejunostomy and gastroenterostomy|PROCEDURE: Stent strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Tolerability & Immunogenicity of BNT162b2 in Immunocompromised Participants ≥2 Years
Status: COMPLETED
Conditions: SARS-CoV-2 Infection, COVID19
Interventions: BIOLOGICAL: BNT162b2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Invitro Expanded Bone Marrow Derived Allogeneic Mesenchymal Stem Cell Transplantation Via Portal Vein or Hepatic Artery or Peripheral Vein in Patients With Wilson Cirrhosis
Status: COMPLETED
Conditions: Wilson's Disease
Interventions: GENETIC: allogeneic mesenchymal stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PD-L1 PET Imaging During Neoadjuvant (Chemo)Radiotherapy in Esophageal and Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer Stage|Oesophageal Cancer
Interventions: RADIATION: CRT|RADIATION: SCPRT|RADIATION: CROSS Protocol|DIAGNOSTIC_TEST: PD-L1 PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Couple Interaction and Health Behaviors
Status: COMPLETED
Conditions: Couples|Relationship, Marital
Interventions: OTHER: Cognitive Intervention|BEHAVIORAL: Behavioral Intervention|OTHER: Interpretation Bias|OTHER: Evaluative Conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Abbreviated Biparametric MRI (RSI + T2WI) for Prostate Cancer Detection: Correlation With Histopathology
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer
Interventions: DEVICE: restriction spectrum imaging (RSI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: INTRAGO-Intraoperative Radiotherapy for Glioblastoma - a Phase I/II Study
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: RADIATION: Intraoperative Radiotherapy (Applicator Surface Dose: 20-40 Gy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Pioglitazone and Exenatide on Body Weight and Beta Cell Function
Status: COMPLETED
Conditions: Type 2 Diabetes|Healthy|Impaired Glucose Tolerance
Interventions: DRUG: Pioglitazone|DRUG: Exenatide|DRUG: Pioglitazone and Exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Viaskin Milk in Children With IgE-Mediated Cow's Milk Allergy
Status: COMPLETED
Conditions: Food Allergy
Interventions: BIOLOGICAL: Viaskin Milk 150 mcg|BIOLOGICAL: Viaskin Milk 300 mcg|BIOLOGICAL: Viaskin Milk 500 mcg|BIOLOGICAL: Viaskin Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Clinical Trial to Evaluate LIT-00814 Tablets in Patients With Advanced Solid Tumor
Status: ENROLLING_BY_INVITATION
Conditions: Advanced Solid Tumor
Interventions: DRUG: LIT-00814
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of 0.12% Chlorhexidine Gluconate for Peri-implant Mucositis
Status: COMPLETED
Conditions: Mucositis
Interventions: DRUG: Chlorhexidine gluconate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficiency of Chest Physiotherapy Applied in a Different Order
Status: COMPLETED
Conditions: Respiratory Disease
Interventions: OTHER: Chest Physiotherapy- Aspiration- Inhaler drugs group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Peer Comparison Feedback on Opioid Prescribing
Status: COMPLETED
Conditions: Opioid Use
Interventions: BEHAVIORAL: Personal Feedback|BEHAVIORAL: Peer Normative Comparison Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Role of Mirtazapine in Ameliorating Sleep Disordered Breathing
Status: COMPLETED
Conditions: Spinal Cord Injuries|Sleep Disordered Breathing
Interventions: DRUG: Mirtazapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effect of Progressive Relaxation Exercıses on Dyspnea and Comfort Level in Individuals With COPD
Status: COMPLETED
Conditions: Copd|Dyspnea|Nursing Caries
Interventions: BEHAVIORAL: progressive relaxation exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Timing of the Nebulization Related to the Physiotherapy Session
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: PROCEDURE: Airway clearance technique|DRUG: Amikacin nebulization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Urine Trypsinogen 2 Dipstick for the Early Detection of Post-ERCP Pancreatitis
Status: COMPLETED
Conditions: Post-ERCP Acute Pancreatitis
Interventions: DEVICE: Actim Pancreatitis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Assess the Absolute Bioavailability of Oral Selumetinib in Healthy Male Volunteers.
Status: COMPLETED
Conditions: Healthy Volunteers Bioavailability Study
Interventions: DRUG: selumetinib 75mg single dose|OTHER: [14C] selumetinib IV solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Efficacy and Safety of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis
Status: RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis|Interstitial Lung Disease
Interventions: DRUG: Placebo|DRUG: Inhaled Treprostinil|DEVICE: Treprostinil Ultrasonic Nebulizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultravision™ System to Facilitate Low Impact Laparoscopic Surgery for Endometriosis
Status: COMPLETED
Conditions: Endometriosis
Interventions: DEVICE: Ultravision™ Visual Field Clearing System|DEVICE: Ultravision Ionwand™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC