pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Assessing the Efficacy of Repeat, Monthly Treatments of Cutaneous Neurofibromas (cNFs)
Status: NOT_YET_RECRUITING
Conditions: Neurofibromas, Cutaneous|Neurofibromatosis 1
Interventions: DRUG: Kybella|DRUG: Asclera|DEVICE: 755nm Alexandrite Laser|DEVICE: 1064nm Nd:YAG Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Treatment of the Mandibular Dental Crowding With and Without Corticotomy Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Research|Orthodontics|Surgery, Oral|Maxillofacial Surgery|Tooth Disorder
Interventions: PROCEDURE: Test group with corticotomy surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In Vivo Kinematics for Subjects Having a MicroPort Medial Pivot or DePuy Attune PCR TKA
Status: NOT_YET_RECRUITING
Conditions: Total Knee Arthroplasty|Osteo Arthritis Knee|Knee Injuries|Knee Imlant
Interventions: DEVICE: MicroPort Medial Pivot TKA|DEVICE: DePuy Attune PCR TKA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Causal Prophylactic Efficacy of KAF156 in a Controlled Human Malaria Challenge Model
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: KAF156|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics of Midazolam, With and Without Concomitant Administration of Crobenetine in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Midazolam, tablet|DRUG: Crobenetine, i.v. infusion|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Disposable Powered Articulating Linear Cutter Stapler in Total-Thoracoscopic Anatomic Lobectomy (Segmentectomy)
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DEVICE: Disposable Powered Articulating Endoscopic Linear Cutter Stapler|DEVICE: ECHELON Flex Powered Articulating Endoscopic Linear Cutters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Enfuvirtide (Fuzeon) in Patients With Advanced Human Immunodeficiency Virus-1 (HIV-1) Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: enfuvirtide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MIrabegron With oveRACtive bLadder Symptoms in mEn
Status: UNKNOWN
Conditions: Overactive Bladder
Interventions: DRUG: mirabegron|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Senolytic and Anti-Fibrotic Agents to Improve the Beneficial Effect of Bone Marrow Stem Cells for Osteoarthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Fisetin|DRUG: Losartan|DRUG: Placebo - Losartan|DRUG: Placebo Fisetin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mycophenolic Acid (MPA) Monotherapy in Liver Transplantation
Status: TERMINATED
Conditions: Liver Transplant
Interventions: DRUG: Group 1 Donor Specific Regulation (DSR) +, Mycophenolic acid (MPA) monotherapy|OTHER: data and sample collection|OTHER: data and sample collection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Sleep With the Far-infrared Emitting Pyjamas
Status: COMPLETED
Conditions: Sleep Disorder
Interventions: DEVICE: Far-infrared emitting pyjamas|DEVICE: Sham-pyjamas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pediatric Hydroxyurea in Sickle Cell Anemia (PED HUG)
Status: COMPLETED
Conditions: Anemia, Sickle Cell|Hematologic Diseases|Hemoglobinopathies
Interventions: DRUG: hydroxyurea
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Vaginal PROgesterone as Maintenance Treatment After an epISode of prEterm Labor (PROMISE Study)
Status: COMPLETED
Conditions: Threatened Premature Labor
Interventions: DRUG: Progesterone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study of BMN 044 in Duchenne Muscular Dystrophy (DMD)
Status: TERMINATED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: BMN 044 IV 6 mg/kg|DRUG: BMN 044 IV 9 mg/kg|DRUG: BMN 044 SC 6 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate if Neoadjuvant Radiotherapy Improves Recurrence Free Survival in Pancreatic Head Cancer
Status: TERMINATED
Conditions: Pancreatic Adenocarcinoma
Interventions: RADIATION: neoadjuvant RTx|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adding Auricular Acupuncture to Xiao-Feng-San Decoction for Treating Atopic Dermatitis
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: OTHER: Auricular acupuncture|OTHER: Sham auricular acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About the Safety of Vedolizumab and How Well it Works in Children and Teenagers With Active Chronic Pouchitis
Status: NOT_YET_RECRUITING
Conditions: Pouchitis
Interventions: DRUG: Vedolizumab|DRUG: Concomitant Antibiotic Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Quantiferon-TB Gold Assay With Tuberculin Skin Testing in Patients With Chronic Liver Disease
Status: COMPLETED
Conditions: Chronic Liver Disease|Liver Transplantation|Tuberculosis
Interventions: PROCEDURE: Tuberculin skin test|PROCEDURE: Quantiferon-TB Gold assay
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dichlorphenamide for Periodic Paralyses and Associated Sodium Channel Disorders
Status: COMPLETED
Conditions: Paralysis, Hyperkalemic Periodic|Hypokalemic Periodic Paralysis|Paramyotonia Congenita
Interventions: DRUG: dichlorphenamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Oral Paclitaxel Efficacy Safety and PK in Recurrent and Metastatic Breast Cancer
Status: COMPLETED
Conditions: Recurrent or Metastatic Breast Cancer
Interventions: DRUG: DHP107|DRUG: IV Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety, Tolerability, Pharmacokinetics,and Clinical Activity of FB704A
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: FB704A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Perceptions of E-Cigarettes and Synthetic Cooling Agents, The ICE Study
Status: RECRUITING
Conditions: Abuse Tobacco|Exposure
Interventions: BEHAVIORAL: Behavioral Intervention|OTHER: Biospecimen Collection|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites (PfSPZ Vaccine) During Malaria Transmission Season in Healthy African Adult Women of Childbearing Potential in Mali
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: PfSPZ Vaccine|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Surgery Plus Intraoperative Radiotherapy as Treatment for Squamous Cell Carcinoma Over Pilonidal Disease.
Status: COMPLETED
Conditions: Squamous Cell Carcinoma|Pilonidal; Cyst, Malignant|Surgery
Interventions: PROCEDURE: Resection plus intraoperative radiotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Impact of Two Different Insulin Dose Calculation on Postprandial Glycemia After Mixed Meal.
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Insulin Glulisine|DRUG: Insulin Aspart|DRUG: Insulin Lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DRUG: edoxaban|DRUG: enoxaparin sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Nature-Based Virtual Reality (VR) Intervention in Family Caregivers of Allogeneic Hematopoietic Stem Cell Transplant (HSCT) Recipients
Status: RECRUITING
Conditions: Neoplasm|Caregivers
Interventions: DEVICE: Sham VR|DEVICE: Active VR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 3 Study of EBI-005 in Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Disease (DED)
Interventions: DRUG: Active Comparator EBI-005|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Establishment of an ELISA for the Recognition of Procalcitonin Variants in Patients With Hyperprocalcitonemia.
Status: COMPLETED
Conditions: Sepsis|Pre-Eclampsia|Granulomatosis With Polyangiitis|Microscopic Polyangiitis|Adiposity|SIRS|Procalcitonin
Interventions: DIAGNOSTIC_TEST: Procalcitonin-variants ELISA-Assay
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Feasibility and Acceptability of an Online Program to Promote Physical Activity Among Black Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Sedentary Behavior|Lack of Physical Activity|Physical Inactivity
Interventions: BEHAVIORAL: LADIES online intervention (R33 phase)|BEHAVIORAL: LADIES online control (R33 phase)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neoadjuvant Irradiation of Retroperitoneal Soft Tissue Sarcoma With Ions Retro-Ion
Status: RECRUITING
Conditions: Sarcoma,Soft Tissue
Interventions: RADIATION: Proton radiation|RADIATION: Carbon Ion radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-AraG PET/CT as a Non-Invasive Imaging Biomarker for Chemoradiation Treatment Response in Esophageal Cancer
Status: NOT_YET_RECRUITING
Conditions: Esophageal Cancer
Interventions: DRUG: ArabinoFuranosylGuanine [18F]F-AraG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficiency Study of CD19-PD1-CART Cell in Relapsed/Refractory B Cell Lymphoma
Status: UNKNOWN
Conditions: Lymphoma, B-Cell
Interventions: BIOLOGICAL: CD19-PD1-CART Cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: K-HEALTH in AIR - Barcelona Pilot - Cohort
Status: ENROLLING_BY_INVITATION
Conditions: Severe Asthma|COPD
Interventions: OTHER: Air quality monitoring at patient's home|OTHER: Questionnaires: Baseline & every six months|DIAGNOSTIC_TEST: Lung function Testing: Baseline & every six months & during exacerbations|OTHER: EMR & registry data|DEVICE: Communication channel - Health Circuit Mobile App (Herranz C. JMIR 2023)|DEVICE: Physiological data - Beat One Watch|DEVICE: Patient Empowerment|OTHER: Characteristics of exacerbations
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mifepristone and Misoprostol Versus Misoprostol Alone for Missed Abortion: A Randomized-controlled Trial
Status: TERMINATED
Conditions: Missed Abortion|Pregnancy
Interventions: DRUG: Mifepristone|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Carbon Ions vs Standard Radiotherapy for Radioresistant Tumors
Status: RECRUITING
Conditions: Malignant Tumors as Chordoma, Adenoid Cystic Carcinoma and Sarcoma
Interventions: RADIATION: Carbon ions therapy|RADIATION: Advanced external radiotherapy by Xrays or protons
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Down Syndrome Memantine Follow-up Study
Status: COMPLETED
Conditions: Down Syndrome|Intellectual Disability
Interventions: DRUG: Memantine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
Status: RECRUITING
Conditions: Surgery|Pain, Postoperative
Interventions: DRUG: NSAID|DRUG: Opioid|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-coated Balloon Versus Drug-eluting Stent in Acute Myocardial Infarction
Status: UNKNOWN
Conditions: Coronary Artery Disease|Acute Myocardial Infarction
Interventions: PROCEDURE: Treatment according arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PROvenge Treatment and Early Cancer Treatment
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: OTHER: Control|BIOLOGICAL: Sipuleucel-T
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electrical Stimulation in Traumatic Brain Injury (TBI) Induced Aphasia
Status: UNKNOWN
Conditions: Aphasia|TBI (Traumatic Brain Injury)|tDCS
Interventions: OTHER: anodal transcranial direct current stimulation (tDCS)- accompanied naming therapy or sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Infusion Duration Study To Assess Tolerability of Pegloticase Administered With a Shorter Infusion Duration in Subjects With Uncontrolled Gout Receiving Methotrexate
Status: COMPLETED
Conditions: Chronic Uncontrolled Gout|Gout|Uncontrolled Gout
Interventions: BIOLOGICAL: Pegloticase with MTX
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Study Medication (Etrasimod) When Mixed With Food in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Estraimod Immediate Release (IR)|DRUG: Etrasimod Mini Tab in water|DRUG: Etrasimod Mini Tab in chocolate pudding|DRUG: Etrasimod Mini Tab in yogurt|DRUG: Etrasimod Mini Tab in applesauce
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Heat Therapy Versus Exercise Training in Hypertension
Status: COMPLETED
Conditions: Hypertension|Cardiovascular Diseases|Arterial Hypertension
Interventions: OTHER: Heat Therapy Group|OTHER: Aerobic Exercise Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Type 2 Diabetes Prevention in Community Health Care Settings for at Risk Children and Mothers
Status: TERMINATED
Conditions: PreDiabetes|Type 2 Diabetes
Interventions: BEHAVIORAL: 16-Week Diabetes Prevention Program for Mothers and Children
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Effect of AZD0780 on the Pharmacokinetics of Rosuvastatin.
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: AZD0780|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Treatment of Chronic Itch in Atopic Dermatitis With Opioid Antagonist Naltrexone
Status: WITHDRAWN
Conditions: Atopic Dermatitis|Pruritus|Pruritus Chronic|Dermatitis
Interventions: DRUG: Naltrexone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Leucine-enriched Nutraceutical and Attenuating Muscle Loss
Status: COMPLETED
Conditions: Muscle Loss
Interventions: DIETARY_SUPPLEMENT: Leucine-enriched protein gel delivery system|DIETARY_SUPPLEMENT: Milk protein gel delivery system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Amount of Glycopyrrolate Absorbed in the Lungs After Taking the Medicine With a eFlow Nebulizer and Seebri® Breezhaler® With and Without Activated Charcoal in Subjects With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD).
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: SUN-101 via eFlow nebulizer|DRUG: SUN-101 via eFlow nebulizer with activated charcoal|DRUG: Seebri® Breezhaler®|DRUG: Seebri® Breezhaler® with activated charcoal|DRUG: Glycopyrrolate Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Follow-up Study on Safety and Maintenance of Efficacy of ATX-101
Status: COMPLETED
Conditions: Submental Fat|Healthy
Interventions: DRUG: ATX-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Clinical Trial to Assess the Effects of Candesartan on the Carbohydrate Metabolism of Obese Subjects
Status: TERMINATED
Conditions: Glucose Intolerance|Obesity
Interventions: DRUG: Candesartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Healing and Empowering Alaskan Lives Towards Healthy-Hearts Study
Status: COMPLETED
Conditions: Tobacco Dependence
Interventions: BEHAVIORAL: Tobacco/Physical Activity Intervention|BEHAVIORAL: Diet plus BP/CHOL Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Imaging of Myocardial Fibrosis in Cardiac Amyloidosis
Status: RECRUITING
Conditions: Cardiac Amyloidosis
Interventions: DRUG: [68Ga]CBP8 PET/MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: O6-Benzylguanine and Temozolomide in Treating Young Patients With Recurrent or Progressive Gliomas or Brain Stem Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: O6-benzylguanine|DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Establishment of a Primary Epididymal Cell Model From Epididymal Samples to Study CFTR Gene Regulation
Status: NOT_YET_RECRUITING
Conditions: Cystic Fibrosis|Congenital Bilateral Absence of Vas Deferens|Sterility, Male
Interventions: PROCEDURE: Epididymal sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Intradermal Acupuncture for Major Depressive Disorder
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DRUG: SSRIs|PROCEDURE: SIA|PROCEDURE: AIA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tiotropium/Salmeterol/Fluticasone Fixed Dose Combination Tratment Via Discair vs Tiotropium Via Handihaler + Salmeterol/Fluticasone Via Diskus Free Combination Treatment
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Tiotropium/Salmeterol/Fluticasone 9/50/500 mcg Inhalation Powder|DRUG: Tiotropium 18 mcg Inhalation Powder|DRUG: Salmeterol/Fluticasone 50/500 mcg Inhalation Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 0050-19-RMB CTIL - VNOTES Compared to VH for Vaginal Apex Prolapse
Status: UNKNOWN
Conditions: Vaginal Prolapse
Interventions: PROCEDURE: VNOTES/VH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Low-fiber Diet for Colorectal Cancer Screening Colonoscopy
Status: COMPLETED
Conditions: Colonic Diseases
Interventions: DIETARY_SUPPLEMENT: Low-residue diet|DIETARY_SUPPLEMENT: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ileal Reservoir Length and Functional Outcome in Ileal Pouch-anal Anastomosis: An Assessor-blinded, Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Ulcerative Colitis|Familial Adenomatous Polyposis
Interventions: PROCEDURE: 10 cm pouch|PROCEDURE: 15 cm pouch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Differences in Malaria Infection Levels in HIV-infected Infants and Children Receiving PI- and NNRTI-based HAART
Status: COMPLETED
Conditions: HIV Infections|Malaria
Interventions: DRUG: Lamivudine|DRUG: Lopinavir/Ritonavir|DRUG: Nevirapine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing the Safety and Efficacy of AR-13324 to Latanoprost in Patients With Elevated Intraocular Pressure
Status: COMPLETED
Conditions: Ocular Hypertension|Open Angle Glaucoma
Interventions: DRUG: AR-13324 Ophthalmic Solution 0.01%|DRUG: AR-13324 Ophthalmic Solution 0.02%|DRUG: Latanoprost ophthalmic solution 0.005%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fetoscopic Endoluminal Tracheal Occlusion (FETO) for Congenital Diaphragm Hernia
Status: RECRUITING
Conditions: Congenital Diaphragmatic Hernia
Interventions: DEVICE: FETO therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: An Exploratory Analysis of Immune and Inflammatory Response Associated With Clozapine
Status: RECRUITING
Conditions: Treatment-resistant Schizophrenia
Interventions: DRUG: Clozapine|DRUG: Antipsychotics,Other (non-Clozapine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Safety and Immunogenicity Study of Intranasal Sendai Virus Vectored Respiratory Syncytial Virus (SeVRSV) Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Antiviral Prophylaxis|Respiratory Syncytial Virus Infection
Interventions: OTHER: Placebo|BIOLOGICAL: SeVRSV Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II Umbrella Study Directed by Next Generation Sequencing
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Avitinib Maleate|DRUG: Afatinib|DRUG: Crizotinib|DRUG: X-396|DRUG: Chidamide|DRUG: Pyrotinib Maleate|DRUG: AZD3759|DRUG: Pirotinib|DRUG: Nimotuzumab|DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Sintilimab|DRUG: Gemcitabine|DRUG: Gemcitabine|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Chemo-Immunotherapy in Head and Neck Cancer Patients
Status: UNKNOWN
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: Cyclophosphamide, Docetaxel, Dendritic cells, OK-432
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapy Based on Stage of Disease and Risk Assessment in Treating Children With Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: DRUG: carboplatin|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: dacarbazine|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: melphalan|DRUG: mesna|DRUG: vincristine sulfate|DRUG: vindesine|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: conventional surgery|RADIATION: low-LET cobalt-60 gamma ray therapy|RADIATION: low-LET electron therapy|RADIATION: low-LET photon therapy|RADIATION: radioisotope therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Calcium Channel Blockers (CCBs) or Diuretics as an Add-on to Olmesartan Medoxomil in Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: olmesartan medoxomil and a CCB|DRUG: olmesartan medoxomil and a diuretic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intranasal Fentanyl at Reducing Pain During Abscess Incision and Drainage (I&D) in Children
Status: COMPLETED
Conditions: Abscess|Pain
Interventions: DRUG: Intranasal Fentanyl|DRUG: Intravenous Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Oseltamivir Treatment of Influenza in Children 1-3 Years of Age
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: oseltamivir|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Genetic Analysis in Blood and Tumor Samples From Patients With Advanced or Metastatic Estrogen Receptor Positive and HER2 Negative Breast Cancer Receiving Palbociclib and Endocrine Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Breast Carcinoma|Locally Advanced Breast Carcinoma|Metastatic Breast Carcinoma|Recurrent Breast Carcinoma|Stage III Breast Cancer AJCC v7|Stage IIIA Breast Cancer AJCC v7|Stage IIIB Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7|Stage IV Breast Cancer AJCC v6 and v7
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|OTHER: Laboratory Biomarker Analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PET-CT Scans in Healthy Volunteers After Flu Vaccination
Status: TERMINATED
Conditions: Flu
Interventions: BIOLOGICAL: FluShield|BIOLOGICAL: FluShield - same arm|BIOLOGICAL: FluShield - opposite arm|PROCEDURE: Blood Draws|PROCEDURE: FDG PET-CT Scan|GENETIC: Cytokine Profiling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effectiveness of Cognitive Behavioral Treatment and Mindfulness Based Stress Reduction (MBSR) for Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: BEHAVIORAL: Cognitive Behavioral Treatment|BEHAVIORAL: Mindfulness Based Stress Reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Double-blind, Placebo-Controlled Pilot Study of Bupropion to Promote Smoking Cessation During Pregnancy
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Bupropion SR|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Project AFECT (Autism Family Empowerment Coaching and Training Program)
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Autism|Autism Spectrum Disorders|Autistic Disorder|Autistic Spectrum Disorder|Autistic Spectrum Disorders|Autistic Disorders Spectrum
Interventions: BEHAVIORAL: Autism Family Empowerment Coaching and Training Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction
Status: RECRUITING
Conditions: Type2diabetes
Interventions: BEHAVIORAL: Caloric Restriction|DRUG: Hyperglycemic clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Role of Androgen Deprivation Treatment (ADT) in Docetaxe-Prednisolone Chemotherapy for Castrate-Resistant Prostatic Cancer
Status: UNKNOWN
Conditions: Castration-resistant Prostate Cancer
Interventions: DRUG: ADT|DRUG: No ADT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Effect of a Combination of Dipyridamole With Sustained Release and Acetyl Salicylic Acid (Aggrenox®) on the Performance Relevant to Safety and on the General Condition of Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Aggrenox®|DRUG: Placebo|OTHER: Ethanol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study That Provides Long-term Safety Follow-up and Examines Long-term Exposure to Abiraterone Acetate
Status: COMPLETED
Conditions: Metastatic Castration-resistant Prostate Cancer|Metastatic Breast Cancer
Interventions: DRUG: Abiraterone acetate|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment De-Intensification for Squamous Cell Carcinoma of the Oropharynx
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of Oropharynx
Interventions: RADIATION: IMRT|DRUG: Cisplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Therapeutic Equivalence Trial of Two Hormonal-IUDs in Patients With Heavy Menstrual Bleeding
Status: COMPLETED
Conditions: Heavy Menstrual Bleeding
Interventions: DRUG: Levosert-20|DRUG: Mirena
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Impairment in Pediatric Onset Multiple Sclerosis
Status: COMPLETED
Conditions: Pediatric Onset Multiple Sclerosis|ADHD Predominantly Inattentive Type
Interventions: BEHAVIORAL: Attention Processing Training program (APT)|BEHAVIORAL: nonspecific computer training (n-ST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paroxysmal Atrial Fibrillation: Role of Inflammation, Oxidative Stress Injury and Effect of Statins
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: 3-Dimensional Conformal Radiation Therapy Versus Intensity Modulated Radiation Therapy
Status: COMPLETED
Conditions: Lung Cancer
Interventions: PROCEDURE: Intensity Modulated Radiation Therapy|PROCEDURE: 3-Dimensional Conformal Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Recombinant CMV gB Vaccine in Postpartum Women
Status: COMPLETED
Conditions: Cytomegalovirus Infections
Interventions: BIOLOGICAL: CMV gB vaccine|DRUG: MF59 adjuvant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Autologous Implantation of Mesenchymal Stem Cells for the Treatment of Distal Tibial Fractures
Status: COMPLETED
Conditions: Tibial Fracture
Interventions: PROCEDURE: autologous mesenchymal stem cells implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-blinded, 6 Months Study With Bydureon® or Placebo in Adolescents With Obesity to Explore Changes in BMI
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Exenatide|BEHAVIORAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Leflunomide Versus Azathioprine for Maintenance Therapy of Lupus Nephritis
Status: UNKNOWN
Conditions: Nephritis|Lupus
Interventions: DRUG: Leflunomide|DRUG: Azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Ivermectin and Colchicine in Treatment of COVID-19: Randomized Controlled Clinical Trial
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Ivermectin Tablets|DRUG: Colchicine 0.5 MG|DRUG: Standared managment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Multi-Modal Anesthesia Protocol in Pain Management of Patients Undergoing Posterior Lumbar Spinal Fusion Surgery
Status: COMPLETED
Conditions: Pain Management|Posterior Spinal Fusion
Interventions: DRUG: Toradol|DRUG: Morphine|DRUG: Orphenadrine|DRUG: Gabapentin|DRUG: Acetaminophen|DRUG: Bupivacaine|DRUG: Epinephrine|DRUG: Xylocaine Injectable Solution|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chronic Aphasia - Improved by Intensive Training and Electrical Brain Stimulation (CATS)
Status: UNKNOWN
Conditions: Aphasia|Anomia (Word-Finding Impairment)
Interventions: BEHAVIORAL: Intensive language therapy|DEVICE: transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endostar Combined With NVB and DDP Second-line Treatment of Advanced Esophageal Squamous Cell Carcinomas
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: NVB|DRUG: DDP|DRUG: Endostar
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Dexamethasone in the Treatment of Patients With Macular Edema Following Retinal Vein Occlusion (RVO)
Status: COMPLETED
Conditions: Macular Edema
Interventions: DRUG: 700 μg Dexamethasone|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Mechanical Insufflation-Exsufflation in Preventing Respiratory Failure After Extubation
Status: COMPLETED
Conditions: Post-extubation Failure|Persistent Weaning Failure|Secretion Encumbrance|Weak Cough|Ventilatory Failure
Interventions: DEVICE: Mechanical Insufflation Exsufflation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating Intepirdine (RVT-101) on Gait and Balance in Subjects With Dementia
Status: COMPLETED
Conditions: Alzheimer's Disease|Dementia With Lewy Bodies|Parkinson's Disease Dementia
Interventions: DRUG: RVT-101 35 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Pharmacokinetics, Safety and Tolerability of CT327 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Safety
Interventions: DRUG: 0.01% CT327 (or placebo)|DRUG: 0.001% CT327 (or placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of TMS Effects on Pain and Depression in Patients With Fibromyalgia
Status: COMPLETED
Conditions: Major Depression|Fibromyalgia
Interventions: DEVICE: Active TMS|DEVICE: Sham TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Eagle AF (Atrial Fibrillation) - Endoscopically Guided Laser Ablation of Persistent Atrial Fibrillation
Status: UNKNOWN
Conditions: Persistent Atrial Fibrillation
Interventions: DEVICE: Endoscopically guided laser ablation HeartLight system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Involvement of IL-17 / IL-22 Pathway in Bacterial Exacerbations of COPD
Status: RECRUITING
Conditions: Pulmonary Disease, Chronic Obstructive|Bacterial Infections
Interventions: OTHER: Sample collecting|OTHER: Lung function measure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Exploratory Study Evaluating Fluorodeoxyglucose - Position Emission Tomography as a Predictive Marker for Therapy With RAD001 in Metastatic Renal Cell Cancer
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: RAD001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ENVASARC: Envafolimab And Envafolimab With Ipilimumab In Patients With Undifferentiated Pleomorphic Sarcoma Or Myxofibrosarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Undifferentiated Pleomorphic Sarcoma|Myxofibrosarcoma
Interventions: BIOLOGICAL: Envafolimab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Manhood 2.0: A Community-Based Teen Pregnancy Prevention Program for Young Men
Status: COMPLETED
Conditions: Sexual Behavior|Unprotected Sex
Interventions: BEHAVIORAL: Manhood 2.0|BEHAVIORAL: Post-High School Readiness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: BOTOX® Treatment in Pediatric Upper Limb Spasticity
Status: COMPLETED
Conditions: Pediatrics|Muscle Spasticity|Cerebral Palsy|Stroke
Interventions: BIOLOGICAL: botulinum toxin Type A|DRUG: Normal Saline (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of Agomelatine in the Prevention of Relapse of Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: agomelatine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Surgical Adhesive Drapes for Prevention and Healing of Wound Infections After Total Hip Arthroplasty
Status: COMPLETED
Conditions: Hip Replacement
Interventions: DEVICE: Iodophor-impregnated adhesive drapes group|PROCEDURE: Iodophor-free adhesive drapes group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ridinilazole (SMT19969) Compared With Fidaxomicin for the Treatment of Clostridium Difficile Infection (CDI)
Status: COMPLETED
Conditions: Clostridium Difficile Infection
Interventions: DRUG: Ridinilazole|DRUG: Fidaxomicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Debio 025 (Alisporivir) Combined With Peg-IFNα2a and Ribavirin in Treatment naïve Chronic Hepatitis C Genotype 1 Patients
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Debio 025|DRUG: Peg-IFNα2a|DRUG: Ribavirin|DRUG: Debio 025 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of GIP and GLP-2 on the Secretion of Glucagon in Patients With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: OTHER: GIP-infusion|OTHER: Sodium-chloride|OTHER: GLP-2 infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Non-invasive Measurement of Arterial Stiffness
Status: RECRUITING
Conditions: Anesthesia, Local|Anesthesia
Interventions: DIAGNOSTIC_TEST: Non-invasive measurement of carotid-femoral transit time by Doppler velocimetry (Athys Medical©) - WAKIe R3 2TC®) (PWV in cm/s)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Renal Magnetic Resonance Angiography (MRA) Study Comparing Dotarem and Time Of Flight (TOF)
Status: TERMINATED
Conditions: Renal Artery Stenosis
Interventions: DRUG: Gadoterate meglumine (Dotarem)|OTHER: Time of Flight Magnetic Resonance Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Transdermal Lidocaine for Pain Control During Diagnostic Office Hysteroscopy
Status: UNKNOWN
Conditions: Infertility, Female
Interventions: DRUG: lidocaine patch|DRUG: Sham patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Of Abraxane® And Carboplatin As First-Line Treatment For Triple Negative Metastatic Breast Cancer
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Abraxane|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exenatide Treatment in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: DRUG: Exenatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Donor White Blood Cell Infusion in Treating Patients With Metastatic or Unresectable Cancer
Status: WITHDRAWN
Conditions: Unspecified Adult Solid Tumor, Protocol Specific|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: leukocyte therapy|GENETIC: polymerase chain reaction
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Clinical Feasibility of an Advanced Therapy Medicinal Product (ATMP) Preparation for Autologous Skin Regeneration in Case of Chronic Leg Ulcers
Status: UNKNOWN
Conditions: Leg Ulcer
Interventions: PROCEDURE: Collection of supernumerary biopsies during skin graft pellet procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Determining Feasibility of a Model of Care for Secondary Fracture Prevention
Status: UNKNOWN
Conditions: Osteoporosis
Interventions: DIAGNOSTIC_TEST: Biochemical markers i.e. Serum Ca, PTH, CTX, Albumin, Phosphate, Vitamin D and Bone mineral density Scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Development Of A Blood Test To Improve The Performance Of Breast Cancer Screening
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Breast Benign
Interventions: DEVICE: Breast MRI|DEVICE: Breast Mammogram|OTHER: Blood draw|PROCEDURE: Breast Biopsy|BEHAVIORAL: online participant reported questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p