pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pharmacokinetics of Oral Thiamine
Status: COMPLETED
Conditions: Pharmacokinetics in Healthy Subjects
Interventions: DIETARY_SUPPLEMENT: Thiamine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Food Delivery, Remote Monitoring, and Coaching-Enhanced Education for Optimized Diabetes Management (FREEDOM)
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Digital Health Coaching|DIETARY_SUPPLEMENT: Food Box Delivery|BEHAVIORAL: Remote Patient Monitoring (RPM)|BEHAVIORAL: Diabetes Education Class
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I Study of Aflibercept Plus FOLFIRI (Irinotecan, 5-Fluorouracil, and Leucovorin) in Chinese Patients With Advanced Solid Malignancies
Status: COMPLETED
Conditions: Neoplasm Malignant
Interventions: DRUG: Aflibercept AVE0005|DRUG: Leucovorin|DRUG: Irinotecan|DRUG: 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 17-OHPC in Pregnancy: IM vs SC Routes
Status: TERMINATED
Conditions: Preterm Birth
Interventions: DRUG: 17-Hydroxyprogesterone Caproate 250 mg IM Dose|DRUG: 17-Hydroxyprogesterone Caproate 275 mg SC Dose
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: VH4524184 Proof-of-Concept in Treatment-Naïve Adults Living With HIV-1
Status: RECRUITING
Conditions: HIV Infections
Interventions: DRUG: VH4524184|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Difficult to Control Focal Epilepsy With Repetitive Transcranial Magnetic Stimulation (rTMS)
Status: COMPLETED
Conditions: Epilepsies, Partial
Interventions: DEVICE: figure-of-eight active rTMS coil|DEVICE: round active rTMS coil|DEVICE: sham rTMS coil (figure-of-eight)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Robotic-arm Assisted Total Knee Replacement and Traditional Total Knee Replacement
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: robotic assisted total knee replacement|DEVICE: traditional total knee replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pomalidomide, Dexamethasone, and Filgrastim-sndz in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma-Light Chain Only|Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: DRUG: Dexamethasone|BIOLOGICAL: Filgrastim-sndz|OTHER: Laboratory Biomarker Analysis|DRUG: Pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychophysiological Effects of Thorax Wraps With Ginger and Mustard Flour
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Zingiberis Rhizoma plv.|DRUG: Sinapis nigrea semen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Oxygen on Core Temperature
Status: COMPLETED
Conditions: Cardiac Disease|Cheyne-Stokes Respiration
Interventions: OTHER: Oxygen|OTHER: Air from a placebo oxygen delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: First Line IRESSA™ Versus Carboplatin/Paclitaxel in Asia
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Gefitinib|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NeoFent-I Study; Fentanyl Treatment in Newborn Infants; a Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Study
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Fentanyl (5 microgram/ml) prediluted ampoules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility, Safety and Diagnostic Input of Interventional Cardiac MRI on a Series of 35 Patients With an Indication of Right Cardiac Catheterization.
Status: UNKNOWN
Conditions: Cardiac MRI|Right Cardiac Catheterization
Interventions: PROCEDURE: Cardiac MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study Assessing the Effects of Chemotherapy in Advanced Esophagogastric Adenocarcinoma
Status: UNKNOWN
Conditions: Esophageal Neoplasms|Stomach Neoplasms
Interventions: DRUG: Carboplatin|DRUG: Docetaxel|DRUG: Capecitabine|DRUG: Epirubicin|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Effectiveness of Risperidone Versus Placebo for the Treatment of Conduct Disorder in Children With Mild, Moderate, or Borderline Mental Retardation
Status: COMPLETED
Conditions: Conduct Disorder|Disruptive Behavior Disorder|Oppositional Defiant Disorder
Interventions: DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of tDCS Combined With Pharmacological Treatments for Bipolar Mania
Status: RECRUITING
Conditions: Manic Episode
Interventions: DEVICE: active group of tDCS|DEVICE: sham group of tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoprosthesis Treatment Effects on Human Abdominal Aorta Aneurysms (AAA) Metabolic Activity
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: RADIATION: [18F] Fluorodeoxyglucose PET Scan Imaging|RADIATION: CT scan|BIOLOGICAL: Blood sampling for biological investigations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Zonisamide Treatment of Alcohol Use Disorder: an Evaluation of Efficacy and Mechanism of Action
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: DRUG: Zonisamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effect of M-TAPA on LC
Status: COMPLETED
Conditions: Post Operative Pain
Interventions: PROCEDURE: modified thoracoabdominal nerve block through perichondrial approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Annuloplasty for Not-Severe TR in Patients Undergoing MV Repair Versus Mitral Repair Only (NOSTRUM)
Status: RECRUITING
Conditions: Tricuspid Disease|Mitral Regurgitation
Interventions: PROCEDURE: M & T Repair Group|PROCEDURE: Mitral-Only Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Auricular Neurostimulation for Cyclic Vomiting Syndrome
Status: COMPLETED
Conditions: Cyclic Vomiting Syndrome|Abdominal Migraine
Interventions: DEVICE: Percutaneous neurostimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Pre and Intraoperative ERCP in Treatment of Common Bile Duct Stones
Status: COMPLETED
Conditions: Common Bile Duct Stones.
Interventions: PROCEDURE: preoperative ERCP and LC|PROCEDURE: Intraoperative ERCP and LC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Symptom Burden Guiding Invasive Electrophysiological Study in Paroxysmal Supraventricular Tachycardia
Status: COMPLETED
Conditions: Supraventricular Tachycardia
Interventions: PROCEDURE: Electrophysiological study (and ablation when appropriate)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of the PainCoach App on Pain and Opiate Use After Total Knee Replacement
Status: COMPLETED
Conditions: Total Knee Replacement|Pain|Opioid Use|E-health App
Interventions: BEHAVIORAL: PainCoach app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effectiveness of Supervised Group-based Walking Program Among Older Adults
Status: RECRUITING
Conditions: Physical Inactivity|Social Interaction
Interventions: BEHAVIORAL: Supervised Group-based Intervention|BEHAVIORAL: Non-supervised Group-based Intervention|BEHAVIORAL: Non-supervised Individual-based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Infusion of Allogeneic Umbilical Cord Blood-Derived Cluster of Differentiation Antigen 19 (CD19)-Specific T Cells
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: GENETIC: T-Cell Infusion|PROCEDURE: Cord Blood Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Neuroplasticity Modulation in tDCS Treatment Response Among Schizophrenia Patients With Auditory Hallucination
Status: RECRUITING
Conditions: Schizophrenia
Interventions: DEVICE: Verum Accelerated Transcranial Direct Current Stimulation (acctDCS)|DEVICE: Sham Accelerated Transcranial Direct Current Stimulation (acctDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Efficacy and Safety of CKD-501 Added to D150 Plus D759 Therapy in Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Type2 Diabetes
Interventions: DRUG: CKD-501 0.5mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy/Safety of DP-R207 Tablet Versus CRESTOR Tablet in Patients With Primary Hypercholesterolemia
Status: COMPLETED
Conditions: Primary Hypercholesterolemia
Interventions: DRUG: Rosuvastatin 5mg|DRUG: DP-R207 5/10mg|DRUG: Rosuvastatin 10mg|DRUG: DP-R207 10/10mg|DRUG: Rosuvastatin 20mg|DRUG: DP-R207 20/10mg|DRUG: Placebo (for Rosuvastatin 5mg and DP-R207 5/10mg)|DRUG: Placebo (for Rosuvastatin 10mg and DP-R207 10/10mg)|DRUG: Placebo (for Rosuvastatin 20mg and DP-R207 20/10mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability Study of Meloxicam Injection in Subjects After Abdominal Surgery
Status: NOT_YET_RECRUITING
Conditions: Pain, Post-operative
Interventions: DRUG: Meloxicam Injection 30mg|DRUG: Meloxicam Injection 60mg|DRUG: Nacl 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Dabrafenib Plus Trametinib in Previously Treated Patients With Locally Advanced or Metastatic, Radio-active Iodine Refractory BRAFV600E Mutation-positive Differentiated Thyroid Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Differentiated Thyroid Cancer
Interventions: DRUG: Dabrafenib|DRUG: Trametinib|DRUG: Trametinib placebo|DRUG: Dabrafenib placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Classification of Sagittal Spinal Alignment to Aid Surgical Planning for Adult Spinal Deformity
Status: NOT_YET_RECRUITING
Conditions: Adult Spinal Deformity|Sagittal Deformity|Sagittal Alignment|Sagittal Imbalance
Interventions: PROCEDURE: Correction strategy in reference to our PI-dependent clustering of sagittal alignment|PROCEDURE: Correction strategy in reference to the SAAS score
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CLL Empirical Antibiotic Regimen
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukaemia (CLL)
Interventions: DRUG: metronidazole, clarithromycin, ciprofloxacin and lansoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intraoperative Magnesium Sulfate Infusion on the Occurrence of Emergence Agitation
Status: COMPLETED
Conditions: Agitation,Psychomotor
Interventions: DRUG: Magnesium Sulfate|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of IMRT Radiotherapy Concurrent Chemothrerapy for Anal Cancer
Status: UNKNOWN
Conditions: Anal Cancer
Interventions: RADIATION: Chemo-radiotherapy with IMRT technique|DRUG: Capecitabine|DRUG: Mitomycin C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detachable String Magnetically Controlled Capsule Endoscopy for Follow-up of Patients With Esophageal Diseases
Status: UNKNOWN
Conditions: Esophageal Diseases
Interventions: DIAGNOSTIC_TEST: ds-MCE and EGD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts
Status: COMPLETED
Conditions: Ectropion|Skin Neoplasms
Interventions: DRUG: 5-Fluorouracil|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Protocol for Evaluation of Quarter-Time Cardiac Imaging: 5-Minutes Rest and 3-Minutes Stress Wide Beam Reconstruction (WBR) Versus Full-Time Filtered Back Projection (FBP)
Status: COMPLETED
Conditions: Cardiac Diseases
Interventions: DEVICE: quarter-time stress scans reconstructed by WBR (4SPS) - Xpress3.Cardiac|DEVICE: quarter-time rest scans reconstructed by WBR (6/8/10 SPS) - Xpress3.Cardiac
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Oxycodone-naloxone in Relieving Opioid-related Constipation
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Oxycodone nalaxone prolonged release tablets (OXN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Efficacy and Safety of Octagam 10% in Patients With Dermatomyositis (Idiopathic Inflammatory Myopathy)
Status: COMPLETED
Conditions: Dermatomyositis
Interventions: DRUG: Octagam 10%|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PET Scan as a Screening Tool for Liver Transplant in Patients With Hepatocellular Carcinoma (HCC)
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: OTHER: PET Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Normal Parameters of Cranial Vessels Using Cranial Vascular Duplex Among Egyptian Population
Status: UNKNOWN
Conditions: Atherosclerosis|Atheroma of Cerebral Arteries|Atheroma; Carotid Artery|Atheroma; Cerebral
Interventions: RADIATION: vascular duplex ultrasound imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Testing a Brief and Low Intensity Self-compassion Intervention
Status: COMPLETED
Conditions: Body Image Disturbance|Body Image|Shame
Interventions: BEHAVIORAL: Self-compassion comprising compassionate body scan-1, compassion body scan-2 and short noticing practice|BEHAVIORAL: Self-compassion comprising self-compassion break, loving kindness meditation, and breathing exercise.|BEHAVIORAL: Distraction group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Vorinostat in Treating Patients With Metastatic Melanoma of the Eye
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Uveal Melanoma|Stage IV Uveal Melanoma AJCC v7
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of 18F-Alfatide Injection PET/CT
Status: NOT_YET_RECRUITING
Conditions: Non-Small Cell Lung Cancer NSCLC
Interventions: DRUG: 18F-Alfatide Injection|DRUG: 18F-FDG Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: 5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical Dependence
Status: COMPLETED
Conditions: Opioid Withdrawal|Physical Dependence
Interventions: DRUG: Ondansetron|DRUG: Placebo|DRUG: Morphine|DRUG: Naloxone 0.4 mg/70 kg|DRUG: Naloxone 0.8 mg/70 kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ganciclovir 0,15% Ophthalmic Gel in the Treatment of Adenovirus Keratoconjuntivitis
Status: COMPLETED
Conditions: Conjunctivitis, Viral|Adenoviridae Infections
Interventions: DRUG: Ganciclovir|DRUG: Artificial tear
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MEDI-573 in Combination With SOC in Unresectable or Metastatic HCC.
Status: COMPLETED
Conditions: Unresectable or Metastatic Hepatocellular Carcinoma (HCC)
Interventions: DRUG: MEDI-573 (1 of 3 doses)|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety/Tolerability Profiles of DA-2811 in Healthy Subjects (DA-2811)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: DA-2811|DRUG: DA-2811-R
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Non-cytotoxic Suramin as a Chemosensitizer in Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Suramin Drug:Docetaxel Drug: Carboplatin|DRUG: Placebo Drug: Docetaxel Drug: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Nebulized Bupivacaine Analgesia for Cleft Palate Repair
Status: RECRUITING
Conditions: Cleft Palate
Interventions: DRUG: Bupivacaine Hydrochloride|DRUG: Bupivacaine Hydrochloride|OTHER: 0.9% saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Revanesse Shape + With Lidocaine Versus Juvederm Voluma With Lidocaine for the Correction of Age-Related Midface Volume Deficit / Lipoatrophy at 6 and 12 Months Post-treatment
Status: COMPLETED
Conditions: Volume Deficit in the Mid-face
Interventions: DEVICE: Revanesse Shape + with Lidocaine|DEVICE: Juvederm Voluma with Lidocaine.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of a New Type of Insulin in Participants With Type 1 Diabetes on Insulin Injection Therapy
Status: WITHDRAWN
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Insulin Lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A First Human Dose Study to Investigate Safety and Tolerability of LY2979165 in Healthy Volunteers
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: LY2979165|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison on the Efficacy of Endoscopic Snare Papillectomy With or Without Submucosal Injection
Status: COMPLETED
Conditions: Ampulla of Vater Adenoma
Interventions: PROCEDURE: Papillectomy without injection|PROCEDURE: Papillectomy with injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Transcranial Direct Current Stimulation on Pain Control in Chronic Painful Total Knee Arthroplasty
Status: RECRUITING
Conditions: Pain, Chronic
Interventions: DEVICE: transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Iron Supplementation for Geriatric Hip Fractures
Status: RECRUITING
Conditions: Hip Fractures|Fragility Fracture|Osteoporotic Fractures
Interventions: DRUG: iron sucrose and ferrous lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase Ⅰa Study of Azilsartan Trimethylethanolamine in Healthy Volunteers
Status: UNKNOWN
Conditions: Health
Interventions: DRUG: Azilsartan Trimethylethanolamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Propagermanium in Focal Segmental Glomerulosclerosis Participants Receiving Irbesartan
Status: COMPLETED
Conditions: Focal Segmental Glomerulosclerosis
Interventions: DRUG: Propagermanium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inflammatory Response to Opioid Versus Opioid Free Anesthesia
Status: COMPLETED
Conditions: Morbid Obesity|Opioid Use|Fentanyl Adverse Reaction|Cytokine Storm
Interventions: DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Contrast-enhanced Multispectral Optoacoustic Tomography for Non-invasive Assessment of Diabetic Gastroparesis
Status: NOT_YET_RECRUITING
Conditions: Diabetic Gastroparesis
Interventions: DEVICE: Multispectral Optoacoustic Tomography (MSOT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Addressing Disparities in Lupus Care Through an Integrated Care Management Program
Status: ACTIVE_NOT_RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: BEHAVIORAL: Rheum iCMP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Scalp Block: Hemodynamic Stability and Patient Comfort In Craniotomy Patients
Status: WITHDRAWN
Conditions: Tumor, Brain|Anesthesia, Local
Interventions: DRUG: Lidocaine|DRUG: Sodium chloride|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical and Radiographic Assessment of PRF Versus Lutein Placement
Status: COMPLETED
Conditions: Osteogenesis
Interventions: DIETARY_SUPPLEMENT: Lutein / Zeaxanthin|BIOLOGICAL: Platelet rich fibrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Multistrain Probiotic on Allergic Rhinitis Symptoms and Gut Microbiota Composition in Atopic Patients
Status: RECRUITING
Conditions: Allergic Rhinitis
Interventions: DIETARY_SUPPLEMENT: Multistrain Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Bioequivalence Study on Two Metoprolol Tablet 100mg Formulations
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: BF-Metoprolol Tablet 100mg|DRUG: Betaloc Tablet 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Oral Levonorgestrel Plus Meloxicam, IG-002 Delays Ovulation in Normal Menstruating Women by Seven Days
Status: RECRUITING
Conditions: Pregnancy Prevention
Interventions: DRUG: Levonorgestrel 1.5mg|DRUG: Meloxicam 15 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Hearing Preservation in Adults With Partial Low-Frequency Hearing Implanted With the HiFocus™ Mid-Scala Electrode
Status: TERMINATED
Conditions: Hearing Loss|Deafness|Hearing Disorders|Ear Diseases|Otorhinolaryngologic Diseases
Interventions: DEVICE: HiRes™ 90K Advantage implant with HiFocus™ Mid-Scala electrode
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypofractionated Radiotherapy Post-Lumpectomy in Women With Node Negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: RADIATION: Conventional whole breast radiation schedule|RADIATION: Hypofractionated whole breast radiation schedule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Etanercept for the Treatment of Moderate to Severe Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis|Psoriasis
Interventions: DRUG: Etanercept|DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Using the Roots of a Non Restorable Wisdom Tooth as a Block for Augmentation of Localized Defects
Status: UNKNOWN
Conditions: Augmentation
Interventions: PROCEDURE: tooth block|PROCEDURE: autogenous bone block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Extension of a Long-term Safety Study of ALKS 9072 (Also Known as ALKS 9070)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: ALKS 9072, Low Dose|DRUG: ALKS 9072, High Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: INCAGN01876 in Combination With Immune Therapies in Subjects With Advanced or Metastatic Malignancies
Status: TERMINATED
Conditions: Advanced Malignancies|Metastatic Cancer
Interventions: DRUG: INCAGN01876|DRUG: Epacadostat|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise and Cardiovascular Control During Upright Tilt in Older Adults With Type 2 Diabetes
Status: COMPLETED
Conditions: Cardiovascular|Diabetic
Interventions: BEHAVIORAL: Aerobic Exercise and Strength Exercise|BEHAVIORAL: Strength training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of 1% Metformin Gel Mixed With PRF in Augmenting Narrow Ridge
Status: UNKNOWN
Conditions: Horizontal Ridge Deficiency
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Microvascular and Inflammatory Responses of 0.05 Cyclosporine Eye Drop (II) in Treatment of Dry Eye
Status: UNKNOWN
Conditions: Dry Eye
Interventions: DRUG: Cyclosporine|DEVICE: oculus keratograph, in vivo laser confocal microscopy, Functional slit lamp biomicroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Nitrite for Older Heart Failure With Preserved Ejection Fraction
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: sodium nitrite|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Bioactive Glass and Beta-Tricalcium Phosphate as Bone Graft Substitute
Status: COMPLETED
Conditions: Bone Neoplasm
Interventions: DEVICE: Bioactive glass|DEVICE: Beta-tricalcium phosphate (ChronOs)|PROCEDURE: Autograft|PROCEDURE: Allograft (frozen femoral head)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Accu-Chek DiaPort, a Port System for Continuous Intraperitoneal Insulin Infusion, in Patients With Type I Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DEVICE: Accu-Chek DiaPort
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of AMG and EMG to Avoid Residual Paralysis After General Anesthesia
Status: COMPLETED
Conditions: Observation of Neuromuscular Block|Respiratory Paralysis|Anaesthesia
Interventions: DEVICE: Acceleromyography (AMG, one-dimensionally)|DEVICE: Acceleromyography (AMG, three-dimensionally)|DEVICE: Electromyography (EMG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Investigating the Safety of LEO 158968 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: LEO 158968|DRUG: Placebo|DRUG: LEO 158968|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Renal Artery Denervation In Addition to Catheter Ablation To Eliminate Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation|Hypertension
Interventions: PROCEDURE: catheter ablation|PROCEDURE: renal sympathetic denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: NIH CCR2 AAA Study
Status: RECRUITING
Conditions: Abdominal Aortic Aneurysm (AAA)|No Abdominal Aortic Aneurysm (Non-AAA)
Interventions: DIAGNOSTIC_TEST: AAA Group (Aim 3A)|DIAGNOSTIC_TEST: Non-AAA Group|OTHER: Ex Vivo Human AAA Specimens (Aim 2A)|OTHER: Relationship between radiotracer and CCR2 (Aim 2B)|DIAGNOSTIC_TEST: AAA Group (Aim 3B-Reproducibility)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Bioequivalence Study Comparing Improved Versus Current Orally Disintegrating E2020 10 mg Tablet in Healthy Japanese Adult Males
Status: COMPLETED
Conditions: Healthy Adult
Interventions: DRUG: Donepezil Hydrochloride|DRUG: Donepezil Hydrochloride|DRUG: Donepezil Hydrochloride|DRUG: Donepezil Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Improved Prediction of Functional Recovery After Revascularisation Using Combined Assessment of Myocardial Ischaemia and Viability by CMR - Pilot Study
Status: UNKNOWN
Conditions: Cardiovascular Diseases|Ischemic Cardiomyopathy|Cardiac Ischemia
Interventions: DEVICE: Research CMR scan|DEVICE: Research 3D transthoracic echocardiogram|OTHER: 6-minute walk test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nucleosides And Darunavir/Dolutegravir In Africa
Status: UNKNOWN
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: Darunavir|DRUG: Ritonavir|DRUG: Dolutegravir|DRUG: Zidovudine|DRUG: Tenofovir|DRUG: Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACB Versus IA Analgesia in Knee Arthroscopy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: ACB group|DRUG: IA group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: NIPPV and nBiPAP Methods in Preterm Infants With Respiratory Distress Syndrome
Status: UNKNOWN
Conditions: Prematurity|Respiratory Distress Syndrome
Interventions: DEVICE: noninvasive respiratory support devices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AN2728 Topical Ointment to Treat Mild-to-Moderate Plaque-Type Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: AN2728 ointment, 2%|DRUG: Ointment Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ramipril 10 mg Capsule in Healthy Subjects Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ramipril 10 mg capsule|DRUG: Altace® 10 mg capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation After Reconstruction of the Anterior Cruciate Ligament of the Knee Using the Bioresorbable Interference Screw (SMS): Resorbability, Per- and Post-operative Complications and Articular Functional Recovery.
Status: TERMINATED
Conditions: Anterior Cruciate Ligament Rupture
Interventions: PROCEDURE: Anterior Cruciate Ligament Reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genicular Artery Embolization Vs Observation for Symptomatic Knee Osteoarthritis
Status: RECRUITING
Conditions: Knee Osteoarthritis|Degenerative Joint Disease of Knee
Interventions: DEVICE: Embozene MicroSpheres
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RECOVER-NEURO: Platform Protocol to Measure the Effects of Cognitive Dysfunction Interventions on Long COVID Symptoms
Status: ACTIVE_NOT_RECRUITING
Conditions: Long COVID|Long Covid19|Long Covid-19
Interventions: OTHER: BrainHQ/Active Comparator Activity|OTHER: BrainHQ|OTHER: PASC CoRE|DEVICE: tDCS-active|DEVICE: tDCS-sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Re-assessment of Appendicitis Evaluation During Laparoscopic Appendectomy, Peritoneal Irrigation During Laparoscopic Appendectomy Does the Grade of Contamination Matter?
Status: RECRUITING
Conditions: Appendicitis|Appendectomy
Interventions: PROCEDURE: laparoscopic lavage
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Does Higher (100% Oxygen) Versus Lower (21% Oxygen) During CC+SI During CPR of Asphyxiated Newborns Improve Time to ROSC
Status: WITHDRAWN
Conditions: Heart; Arrest, Newborn|Birth Asphyxia|Bradycardia Neonatal
Interventions: PROCEDURE: Intervention (21% oxygen during CC+SI)|PROCEDURE: Intervention (100% oxygen during CC+SI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of XXB750 in Heart Failure Participants With Reduced or Mildly Reduced Ejection Fraction (HFrEF/HFmrEF)
Status: COMPLETED
Conditions: Heart Failure With Reduced Ejection Fraction (HFrEF)|or Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)
Interventions: DRUG: XXB750|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Magnetic Resonance Imaging Strategy for the Management of Patients With Acute Chest Pain and Detectable to Elevated Troponin
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Chest Pain
Interventions: PROCEDURE: Cardiac MRI|OTHER: ACC/AHA Guideline adherent care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Chinese Herbal Decoction for Stress Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence, Stress
Interventions: DIETARY_SUPPLEMENT: Chinese herbal therapy|BEHAVIORAL: Pelvic floor muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Cyclosporine With Infliximab in Steroid-refractory Severe Attacks of Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis|Steroid Refractory
Interventions: DRUG: CYCLOSPORINE VS INFLIXIMAB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Buzzy® and ShotBlocker® on Pain, Anxiety and Satisfaction During the Administration of Vaccine
Status: COMPLETED
Conditions: Pain|Anxiety|Satisfaction
Interventions: OTHER: ShotBlocker®|OTHER: Buzzy® Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dupilumab and Milk OIT for the Treatment of Cow's Milk Allergy
Status: ACTIVE_NOT_RECRUITING
Conditions: Allergies Food Milk
Interventions: DRUG: Dupilumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dental Plaque Removal Evaluation and Comparison of Kid's Battery-Operated Toothbrush and Manual Toothbrush
Status: COMPLETED
Conditions: Plaque, Dental
Interventions: DEVICE: Battery operated toothbrush|DEVICE: Manual toothbrush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: How Safe and Effective is Micropulse Transscleral Cyclophotocoagulation in Patients With Uncontrolled Glaucoma?
Status: COMPLETED
Conditions: Glaucoma
Interventions: PROCEDURE: Micropulse Transscleral Cyclophotocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vascular and Metabolic Effects of Hormone Therapy Combined With L-Arginine in Postmenopausal Women
Status: COMPLETED
Conditions: Hypercholesterolemia|Postmenopause
Interventions: DRUG: L-arginine|DRUG: Estrogen
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Management of Patients With Heart Failure at Home After Hospital Discharge
Status: NOT_YET_RECRUITING
Conditions: Heart Failure
Interventions: OTHER: Digital follow-up and uptitration of medications at home after hospital discharge for heart failure|OTHER: Follow-up and uptitration of medications at the hospital outpatient-clinic after hospital discharge for heart failure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Short Term Immobilization of the Lower Limb
Status: COMPLETED
Conditions: Weakness, Muscle|Muscle Weakness|Muscle Loss|Muscle Atrophy|Injury, Knee
Interventions: OTHER: Neuromuscular Electrical Stimulation|OTHER: Action Observation + Mental Imagery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Circulating Cell-free DNA-based Epigenetic Biomarker mSEPT9 for Hepatocellular Carcinoma Detection in Cirrhosis
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma|Cirrhosis
Interventions: DIAGNOSTIC_TEST: "Epi proColon 2.0 CE" test from Epigenomics, Inc (Berlin, Germany)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Long-term Versus Short-term Sequential Therapy (Intravenous Itraconazole Followed by Oral Solution) of Itraconazole as Primary Prophylaxis in Patients Undergoing Allogeneic Stem Cell Transplantation
Status: UNKNOWN
Conditions: Hematological Diseases|Allogeneic Stem Cell Transplantation
Interventions: DRUG: itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Texting for Mobility in Overweight/Obese Adults With Peripheral Artery Disease
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: BEHAVIORAL: PACE|BEHAVIORAL: Diet|OTHER: App|OTHER: Face-to-face
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease
Status: WITHDRAWN
Conditions: Lung Cancer|Malignant Mesothelioma|Metastatic Cancer|Nonmalignant Neoplasm|Precancerous Condition
Interventions: PROCEDURE: bronchoscopic and lung imaging studies|PROCEDURE: diagnostic bronchoscopy|PROCEDURE: histopathologic examination|PROCEDURE: optical coherence tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pre-operative Diet: Effect of Wound Healing After Bariatric Surgery
Status: UNKNOWN
Conditions: Obese
Interventions: DIETARY_SUPPLEMENT: Diet group 800 Kcal diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Semi-individualised Chinese Medicine Treatment as an Adjuvant Management for Diabetic Nephropathy
Status: UNKNOWN
Conditions: Diabetic Nephropathies
Interventions: DRUG: Semi-individualised Chinese Medicine treatment|DRUG: Routine medical care (active comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Hyaluronidase (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)-Japan Extension
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: Pembrolizumab coformulated with hyaluronidase|DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Nab-paclitaxel|BIOLOGICAL: Pembrolizumab|DRUG: Filgrastim|DRUG: Pegylated filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Potential Pulmonary Benefit of Low Pressure Laparoscopic Cholecystectomy in Selected Patients
Status: UNKNOWN
Conditions: Cholecystitis/Cholelithiasis|Cholecystitis; Gallstone|Polyp Gallbladder
Interventions: OTHER: Low Pressure Laparoscopic Cholecystectomy|OTHER: Standard Pressure Laparoscopic Cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Laparoscopic Extraperitoneal Total Mesorectal Excision (LE-TME): A New Feasible Technical Approach.
Status: COMPLETED
Conditions: Total Mesorectal Excision|Laparoscopic
Interventions: PROCEDURE: LE-TME
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Mirogabalin for Central Neuropathic Pain
Status: COMPLETED
Conditions: Central Neuropathic Pain
Interventions: DRUG: Placebo|DRUG: Mirogabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioural Therapy Versus Psychoeducation for Perinatal Anxiety
Status: NOT_YET_RECRUITING
Conditions: Perinatal Anxiety
Interventions: BEHAVIORAL: Cognitive Behavioural Group Therapy|BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT