pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of V710 in Adults With Kidney Disease on Hemodialysis (V710-005)(COMPLETED)
Status: COMPLETED
Conditions: Staphylococcus Aureus Infection
Interventions: BIOLOGICAL: Comparator: Placebo (PBO)|BIOLOGICAL: V710 Comparator: Placebo (PBO)|BIOLOGICAL: V710 Comparator: Placebo (PBO)|BIOLOGICAL: V710 Comparator: Placebo (PBO)|BIOLOGICAL: V710 Comparator: Placebo (PBO)|BIOLOGICAL: V710 Comparator: Placebo (PBO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Biomarker Guided Treatment in Gynaecological Cancer
Status: RECRUITING
Conditions: Endometrial Cancer
Interventions: PROCEDURE: Biomarker (ER/PR) guided lymphadenectomy|DRUG: Biomarker guided weekly taxane treatment in endometrial/ ovarian cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NAVADYN11 : Hemodynamic Impact of a New Ventilatory Support Mode With Diaphragmatic Synchronization
Status: TERMINATED
Conditions: Invasive Ventilatory Support
Interventions: OTHER: collection of clinical and biological parameters|OTHER: assign optimal ventilatory mode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bovine Lactoferrin Supplement in Improving Taste in Patients With Cancer Receiving Chemotherapy
Status: COMPLETED
Conditions: Anorexia|Cachexia|Malignant Neoplasm|Oral Complications of Chemotherapy
Interventions: DIETARY_SUPPLEMENT: bovine lactoferrin supplement|OTHER: questionnaire administration|PROCEDURE: quality-of-life assessment|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Relapse Myeloma; Cyclofosfamide; Bortezomib; Maintenance
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib|DRUG: Cyclophosphamide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeting Iatrogenic Cushing's Syndrome With 11β-hydroxysteroid Dehydrogenase Type 1 Inhibition
Status: COMPLETED
Conditions: Iatrogenic Cushing's Disease
Interventions: DRUG: AZD4017 and prednisolone|DRUG: Placebo Oral Tablet and prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Nutritional Supplementation in Patients With Unilateral Wet AMD
Status: COMPLETED
Conditions: Wet Macular Degeneration
Interventions: DIETARY_SUPPLEMENT: Retilut|DIETARY_SUPPLEMENT: Theavit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: California Collaborative Network to Promote Data Driven Care and Improve Outcomes in Early Psychosis
Status: ENROLLING_BY_INVITATION
Conditions: First Episode Psychosis (FEP)
Interventions: COMBINATION_PRODUCT: EPI-CAL data network|DIAGNOSTIC_TEST: Community DUP Assessment Tool
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Tildrakizumab in Participants With Moderate-to-Severe Chronic Plaque Psoriasis Who Are Non-Responders to Dimethyl Fumarate Therapy
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Dimethyl fumarate (DMF) standard scheme|DRUG: Dimethyl fumarate (DMF) simplified scheme|DRUG: Tildrakizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neonatal Precursors of Neurodevelopment
Status: UNKNOWN
Conditions: Premature Birth
Interventions: DEVICE: Electroencephalography-Near infrared spectroscopy|DEVICE: Magnetic resonance imaging|BEHAVIORAL: Psychometric testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Insomnia Treatment on Overnight Regulation of Emotional Memories and Risk for Mental Disorders
Status: NOT_YET_RECRUITING
Conditions: Insomnia Chronic|Depression, Anxiety
Interventions: BEHAVIORAL: CBCTi|BEHAVIORAL: General sleep information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Add-On Trial of Quetiapine in Patients With Bipolar Disorder and Cocaine Dependence
Status: COMPLETED
Conditions: Bipolar Disorder|Cocaine Dependence
Interventions: DRUG: Quetiapine|DRUG: PLacebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ondansetron on Vomiting Due to Acute Gastroenteritis in Pediatric During Winter
Status: TERMINATED
Conditions: Vomiting|Gastroenteritis
Interventions: DRUG: Ondansetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Honey for Pressure Ulcers in Critically Ill Children
Status: COMPLETED
Conditions: Bed Sore|Pressure Ulcer|Pressure Sore|Critically Ill Children
Interventions: OTHER: Honey (medicated)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Rapid Acting Intramuscular Olanzapine and Placebo in Agitated Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Rapid Acting Intramuscular Olanzapine|DRUG: Isotonic sodium chloride solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Ultra Small Dose Decitabine for the Lower Risk MDS Patients With Transfusion Dependent
Status: UNKNOWN
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Choosing the Best Antibiotic to Protect Friendly Gut Bacteria During the Course of Stem Cell Transplant
Status: RECRUITING
Conditions: Intestinal Microbiome|Febrile Neutropenia
Interventions: DRUG: Piperacillin-tazobactam|DRUG: cefepime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerability, Pharmacokinetics and Pharmacodynamics of BIA 9-1067
Status: COMPLETED
Conditions: Parkinson's Disease (PD)
Interventions: DRUG: BIA 9-1067|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Measuring Placebo Effect by Elimination and Investigating Mechanism of Action
Status: COMPLETED
Conditions: Placebo Effect|Placebo Mechanisms of Action
Interventions: DRUG: caffeine/placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Acupuncture Protocol Involving in Weizhong (BL4) and Huantiao (GB30) Points in Treating Ankylosing Spondylitis
Status: UNKNOWN
Conditions: Ankylosing Spondylitis
Interventions: OTHER: Weizhong and Huantiao|OTHER: A-shi point
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Assess the Pharmacodynamic Response in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Fluticasone Propionate/Formoterol Fumarate|DRUG: Fluticasone Propionate/Formoterol Fumarate|DRUG: Fluticasone Propionate/Formoterol Fumarate|DRUG: Fluticasone Propionate/Formoterol Fumarate|DRUG: Fluticasone Propionate/Formoterol Fumarate|DRUG: Formoterol Fumarate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interactive Effects of IV Ethanol and IV Nicotine
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Intravenous ethanol placebo plus nicotine infusions|DRUG: intravenous ethanol 40mg% plus nicotine infusions|DRUG: intravenous ethanol 100mg% plus nicotine infusions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessment of Tear Production, Corneal Staining, and Comfort Level Wearing Different Types of Contact Lenses
Status: NOT_YET_RECRUITING
Conditions: Dry Eye|Dry Eye Syndromes|Contact Lens-induced Corneal Fluorescein Staining
Interventions: DEVICE: Eye Wearing Contact Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pharmacokinetic Study of Lurasidone After Single Oral Administration in Healthy Subjects
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: 20mg lurasidone|DRUG: 40mg lurasidone|DRUG: 80mg lurasidone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Apalutamide With Radiotherapy and Androgen Deprivation Therapy in Prostate Cancer
Status: WITHDRAWN
Conditions: Prostate Cancer
Interventions: OTHER: Radiation Therapy|DRUG: Apalutamide|DRUG: Luteinising Hormone Releasing Hormone analog agonist (LHRHa)|DRUG: Non-steroidal anti-androgen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The PRE-D Trial: Effect of Dapagliflozin, Metformin and Physical Activity in Pre-diabetes
Status: COMPLETED
Conditions: Prediabetic State|Obesity
Interventions: DRUG: Dapagliflozin|DRUG: Metformin|BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of a New Symbiotic Formulation in Children With Familial Hypercholesterolemia
Status: COMPLETED
Conditions: Dyslipidemia|Familial Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: Lactobacillus paracasei B21060|OTHER: low satured diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Neoadjuvant Hormone Therapy in Patient With Advanced Prostate Cancer Undergoing Radical Prostatectomy.
Status: TERMINATED
Conditions: Advanced Prostate Cancer
Interventions: DRUG: Zoladex and Casodex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Nemonoxacin vs Levofloxacin in Adult Patients With Community-Acquired Pneumonia
Status: COMPLETED
Conditions: Pneumonia, Bacterial
Interventions: DRUG: Nemonoxacin|DRUG: Nemonoxacin|DRUG: Tavanic|DRUG: Tavanic|DRUG: Placebo (250 ml)|DRUG: Placebo (100 ml)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Long-Term Safety of PA32540 in Subjects Who Are at Risk for Developing Aspirin-Associated Gastric Ulcers
Status: COMPLETED
Conditions: Aspirin-Associated Gastric Ulcers
Interventions: DRUG: PA32540
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Northwell Health Visits: A Family Connects Pilot Implementation at Northwell Health
Status: COMPLETED
Conditions: Unspecified Child Maltreatment, Suspected|Unspecified Child Maltreatment, Confirmed|Postpartum Depression
Interventions: OTHER: Enhanced Intervention|OTHER: Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Learn More About How Drug Aflibercept Works in Canadian Patients With Reduced Vision Caused by New Blood Vessels Growing in the Eye (Myopic Choroidal Neovascularization or mCNV)
Status: COMPLETED
Conditions: Myopic Choroidal Neovascularization
Interventions: DRUG: Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Determining Whether Durvalumab in Combination With Radiation Therapy Can Prevent the Progression of Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer|Lung Cancer|Nsclc|NSCLC Stage II|NSCLC, Stage III
Interventions: RADIATION: Radiation Therapy|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dopamine Receptor Agonist Therapy for Pain Relief in Women Suffering From Endometriosis: A Pilot Study
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: Cabergoline|DRUG: Norethindrone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Transfer of αCD19-TCRz-41BB and αCD22-TCRz-41BB CAR-T Cells for B-cell Hematologic Malignancy
Status: UNKNOWN
Conditions: Hematopoietic/Lymphoid Cancer
Interventions: BIOLOGICAL: Mixed CAR-T Transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy SBRT Sensitization of the Programmed Death-1 (PD-1) Effect
Status: COMPLETED
Conditions: Metastatic Nonsmall Cell Lung Cancer|Non Small Cell Lung Cancer
Interventions: RADIATION: Stereotactic Body Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Compare Ilioinguinal/Iliohypogastric Block to Wound Infiltration for Pain Relief After Hernia Repair in Adults
Status: COMPLETED
Conditions: To Compare ILI/IHG Block to Wound Infiltration for Pain Relief After Hernia Repair
Interventions: PROCEDURE: Block/Local infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Individualized Analgesia After Adenotonsillectomy
Status: COMPLETED
Conditions: Analgesia
Interventions: DRUG: Individualized opioid analgesia|DEVICE: conventional opioid analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Customised 3D-printed Insoles in Reducing Pain Among Frequent Park Runners
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain
Interventions: DEVICE: Customised 3D-printed insoles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypofractionated Image Guided Proton Therapy for Low andIntermediate Risk Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: Hypofractionated Proton Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intensity-modulated Radiotherapy With or Without Concurrent Chemotherapy for Stage II Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Cisplatin|RADIATION: Intensity-modulated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sitagliptin Metformin Add-on Study in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus (T2DM)
Interventions: DRUG: sitagliptin 100 mg q.d./metformin ≥ 1500 mg/day|DRUG: comparator: placebo to match sitagliptin 100 mg q.d./metformin ≥ 1500 mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Secukinumab in Psoriatic Arthritis and Axial Spondyloarthritis Patients With Active Enthesitis Including One Achilles Tendon Site
Status: COMPLETED
Conditions: Psoriatic Arthritis|Axial Spondyloarthritis|Enthesitis
Interventions: BIOLOGICAL: Secukinumab|DRUG: Secukinumab Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Detection of Chlamydia DNA by Polymerase Chain Reaction in Primary Tubal and Ovarian Cancers Tissues : a Pilot Study
Status: COMPLETED
Conditions: Malignant Neoplasm of Fallopian Tube
Interventions: OTHER: PCR for chlamydia DNA in primary tubal cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigation of 2 Different Oral Formulations of Estradiol and Norethisterone in Healthy Women
Status: COMPLETED
Conditions: Menopause|Healthy
Interventions: DRUG: 2 mg estradiol / 1 mg norethisterone acetate (NETA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: R-CHOP + R-HAD vs R-CHOP Followed by Maintenance Lenalidomide + Rituximab vs Rituximab for Older Patients With MCL
Status: ACTIVE_NOT_RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: R-CHOP|DRUG: R-CHOP / R-HAD|DRUG: Rituximab|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temozolomide, Radiation Therapy, and Tumor Treating Fields Therapy in Treating Participants With Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: Temozolomide|RADIATION: Radiation Therapy|DEVICE: NovoTTF-200A Device|PROCEDURE: Tumor Treating Fields Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Duloxetine vs Pregabalin for Thoracotomy Pain
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Pregabalin|DRUG: Duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Be Healthy in Pregnancy (B-HIP): A Trial to Study Nutrition and Exercise Approaches for Healthy Pregnancy
Status: COMPLETED
Conditions: Excessive Weight Gain in Pregnancy as Antepartum Condition|Obesity|Weight Gain|Type 2 Diabetes
Interventions: BEHAVIORAL: Exercise and Nutrition Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemoradiation With Enadenotucirev as a Radiosensitiser in Locally Advanced Rectal Cancer
Status: COMPLETED
Conditions: Locally Advanced Rectal Cancer
Interventions: BIOLOGICAL: Enadenotucirev|DRUG: Capecitabine|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Training of the Rhythmic Skills With a Serious Game to Improve Gait and Cognitive Abilities in Parkinson's Disease
Status: SUSPENDED
Conditions: Parkinson Disease
Interventions: OTHER: Rhythm workers training Perceptive timing|OTHER: Rhythm workers training sensorimotor timing|OTHER: No Rhythm workers training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ranibizumab in Residual Diabetic Macular Edema Following Previous Anti-VEGF Therapy
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Ranibizumab|DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cross Sectional Study to Evaluate Effects of Kinesiotaping on Muscle Activity During Climbing Stairs and Sport Activity
Status: COMPLETED
Conditions: Physical Activity
Interventions: DEVICE: IQ-Tape|DEVICE: Kinesiotape|OTHER: No-Tape
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improvement of Needle Visibility in Ultrasound Guided Regional Anaesthesia
Status: UNKNOWN
Conditions: Anaesthesia|Trauma
Interventions: DEVICE: ANV(R)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Accuracy of 3D Printed Complete Dentures Using Two Impression Techniques: RCT
Status: COMPLETED
Conditions: Edentulism Nos
Interventions: DEVICE: complete denture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The COVID-RASi Trial (COVID-19)
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19|Cardiovascular Diseases
Interventions: DRUG: Angiotensin converting enzyme inhibitor|DRUG: Angiotensin II Receptor Blockers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient-Controlled Anxiolysis With Dexmedetomidine (PCA-DEX) for Burn-care Dressing Changes
Status: COMPLETED
Conditions: Anxiety|Burns
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Use of a Novel Synbiotic to Change Human Gut Bacteria and Improve Health in Obese Adults
Status: COMPLETED
Conditions: Intestinal Microbiota and Barrier Function
Interventions: DIETARY_SUPPLEMENT: Bifidobacteria adolescentis BD1|DIETARY_SUPPLEMENT: Bifidobacteria animalis subsp. lactis BB-12|DIETARY_SUPPLEMENT: Bifidobacteria adolescentis BD1 and galactooligosaccharide|DIETARY_SUPPLEMENT: Bifidobacteria animalis subsp. lactis BB-12 and galactooligosaccharide|DIETARY_SUPPLEMENT: galactooligosaccharide|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Solid Tumor|Metastatic Solid Tumor|Pancreatic Cancer|Lung Cancer|Head and Neck Cancer|Breast Cancer|Kidney Cancer|Colorectal Cancer|Bladder Cancer|Ovarian Cancer|Sarcoma|Gallbladder Cancer|Bile Duct Cancer|Esophageal Cancer|Uterine Cancer|Cholangiocarcinoma|Prostate Cancer
Interventions: DRUG: Seribantumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation Study of a New Cytokine-based Dynamic Stratification Based on FLt3 Ligand Plasma Concentration Kinetic Profile and IL-6 Concentration During Induction of Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Community Colorectal Cancer Awareness, Research, Education & Screening (C-CARES)
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BEHAVIORAL: Community Colorectal Cancer Awareness, Research, Education & Screening (C-CARES) Materials|BEHAVIORAL: Contact Message|BEHAVIORAL: Personalized One on One Education|DIAGNOSTIC_TEST: Fecal Immunochemical Test (FIT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Computer-Aided Detection (CAD) as Second Reader in CT Colonography
Status: COMPLETED
Conditions: Individuals With Suspected Colorectal Disease
Interventions: PROCEDURE: CT colonography|PROCEDURE: colonoscopy|DEVICE: CT Colonography with computer assisted diagnosis (CAD),CADCOLON -im3D SpA., Torino Italy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of TCD601 (Siplizumab) in New Onset Type 1 Diabetes Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 1
Interventions: BIOLOGICAL: TCD601|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Proactive Management of Side Effects on Treatment Compliance in Malignant Melanoma Patients on High-dose Intron A Therapy (Study P04600)
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: Intron A (interferon alfa-2b; SCH 30500)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Biking vs. Running: Comparison of EPOC, Substrate Oxidation, Appetite and Energy Intakes in Men With Overweight/Obesity.
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effects of Walking Training on Different Surfaces on Walking Ability in Ambulatory Patients With Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries|Rehabilitation
Interventions: OTHER: Rehabilitation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physical Activity in Promoting Smoking Cessation in African Americans
Status: ACTIVE_NOT_RECRUITING
Conditions: Current Smoker|Healthy Subject
Interventions: BEHAVIORAL: Exercise Intervention|OTHER: Laboratory Biomarker Analysis|DRUG: Nicotine Patch|OTHER: Questionnaire Administration|OTHER: Tobacco Cessation Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety for Home Administration of Microdose Psilocybin Use
Status: NOT_YET_RECRUITING
Conditions: Psychedelic Experiences
Interventions: DRUG: psilocybin trihydrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol
Status: COMPLETED
Conditions: General Anesthesia|Intravenous Anesthesia
Interventions: DRUG: Magnesium Sulfate|DRUG: Lidocaine|DRUG: Control|DRUG: Lidocaine/Magnesium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b Study Assessing the PK, PD, Safety & Tolerability of SB414 in Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: SB414 2%|DRUG: SB414 6%|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impaired Toilet Training, LUTS and Bowel Dysfunction in Children With DCD
Status: RECRUITING
Conditions: Developmental Coordination Disorder|Lower Urinary Tract Symptoms|Bowel Dysfunction
Interventions: OTHER: Vancouver symptom score for dysfunctional elimination symptoms Questionnaire|OTHER: Developmental Coordination Disorder Questionnaire|OTHER: Questionnaire concerning impaired toilettraining and comorbities
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Open Label Registry Study of Lutetium-177 (DOTA0, TYR3) Octreotate (Lu-DOTA-TATE) Treatment in Patients With Somatostatin Receptor Positive Tumours
Status: ACTIVE_NOT_RECRUITING
Conditions: Neuroendocrine Carcinoma
Interventions: OTHER: Lu-DOTA-TATE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study Comparing Basic Performance and Hemocompatibility of 3 Different Dialyzers in Hemodialysis Patients
Status: COMPLETED
Conditions: End Stage Renal Disease (ESRD)
Interventions: DEVICE: ELISIO-15H|DEVICE: Revaclear|DEVICE: Optiflux
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of NMN (Nicotinamide Mononucleotide) on Diminished Ovarian Reserve (Including Premature Ovarian Insufficiency)
Status: RECRUITING
Conditions: Diminished Ovarian Reserve|Premature Ovarian Insufficiency
Interventions: DIETARY_SUPPLEMENT: NMN intervention|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Controlled Trial in South Africa Comparing the Efficacy of Complementary Food Products on Child Growth
Status: COMPLETED
Conditions: Malnutrition
Interventions: DIETARY_SUPPLEMENT: Fortified fat-based paste with essential fatty acids, DHA, ARA, phytase, L-lysine, potassium, phosphorous, magnesium and manganese|DIETARY_SUPPLEMENT: Fortified fat-based paste with essential fatty acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Partial Reinforcement II: Three Approaches to Maintenance Therapy for Chronic Insomnia
Status: COMPLETED
Conditions: Insomnia|Insomnia Chronic
Interventions: DRUG: Zolpidem tartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modified TIPS Block for Total Knee Arthroplasty
Status: NOT_YET_RECRUITING
Conditions: Knee Arthropathy|Anesthesia, Local
Interventions: PROCEDURE: General Anesthesia|PROCEDURE: TIPS block|PROCEDURE: Modified TIPS block|PROCEDURE: Mutimodal analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Supplementation of Fish Oil on Non-alcoholic Fatty Liver Disease in Children
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease
Interventions: DIETARY_SUPPLEMENT: Fish Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Erythromycin on the Absorption, Metabolism and Elimination of CHF6001 in Healthy Volunteers
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: CHF6001 DPI|DRUG: Erythromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of GD-iExo-003 in Acute Ischemic Stroke
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DRUG: exosomes derived from human induced pluripotent stem cell for injection|DRUG: a placebo of exosomes derived from human induced pluripotent stem cell for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Safety, and Efficacy of SPRIX in 12 to 17 Year Old Patients vs. Adult Patients Undergoing Open Surgical Procedures
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: SPRIX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Benefit of Preoperative vs. Postoperative Etoricoxib in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Etoricoxib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Cycle Exercise in Wheelchair Users With Muscular Dystrophy or Cerebral Palsy
Status: COMPLETED
Conditions: Muscular Dystrophies|Cerebral Palsy
Interventions: OTHER: Cycle exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immune Response to an Investigational Vaccine Against Respiratory Syncytial Virus in Healthy Adults
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: RSV vaccine MV-012-968 (dosage #1)|BIOLOGICAL: RSV vaccine MV-012-968 (dosage #2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Open-label, Phase I/II Study of the Pan-immunotherapy in Patients With Local Advanced/Metastatic Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: DRUG: Manganese Chloride|DRUG: nab-paclitaxel|DRUG: Gemcitabine|DRUG: anti-PD-1 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lidocaine and Ketamine in Abdominal Surgery
Status: TERMINATED
Conditions: Abdominal Hysterectomy (& Wertheim)
Interventions: DRUG: Lidocaine|DRUG: Placebo|DRUG: Ketamine|DRUG: Ketamine + Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Convalescent Plasma Transfusion for Patients With COVID-19
Status: UNKNOWN
Conditions: COVID-19
Interventions: BIOLOGICAL: convalescent plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inspiratory Muscle Training in Patients Receiving Allogenic Stem Cell Transplantation
Status: UNKNOWN
Conditions: Inspiratory Muscle Training|Stem Cell Transplantation|Respiratory Muscle Training
Interventions: PROCEDURE: Inspiratory Muscle Training|OTHER: inspiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Trial Comparing Conventional Versus Piggyback Method in Venous Drainage of the Transplanted Liver
Status: COMPLETED
Conditions: End-stage Liver Disease
Interventions: PROCEDURE: Piggyback method|PROCEDURE: conventional method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Blinded First CMC Osteoarthritis Treatment
Status: RECRUITING
Conditions: Osteoarthritis Thumb
Interventions: DRUG: Platelet Concentrate|DRUG: Corticosteroid injection|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: 177Lu-PSMA-I&T Prior to Radical Prostatectomy for Locally Advanced Disease
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: RADIATION: 177Lu-PSMA-I&T Radionuclide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Inositol on Glucose Metabolism in Patients With Metabolic Syndrome at Risk of Cardiac Fibrosis
Status: RECRUITING
Conditions: Metabolic Syndrome|Cardiac Fibrosis
Interventions: DIETARY_SUPPLEMENT: Inositol and alpha-lactalbumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Individualized Perioperative Open Lung Ventilatory Approach in Emergency Abdominal Laparotomy. A Prospective Multicenter Randomized Controlled Trial.
Status: UNKNOWN
Conditions: Ventilator Lung
Interventions: PROCEDURE: STD-02|PROCEDURE: iOLA-iHFNC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Vagal Nerve Stimulation in Irritable Bowel Syndrome
Status: RECRUITING
Conditions: Irritable Bowel Syndrome
Interventions: DEVICE: Vagal Nerve Stimulation|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of OXi4503 (a Vascular Disrupting Agent) Given by 3 x Weekly Intravenous Infusions to Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: OXi4503
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nonopioid Pain Control Regimen After Arthroscopic Hip Procedures
Status: RECRUITING
Conditions: Hip Arthroscopy
Interventions: DRUG: Oxycodone|DRUG: Ibuprofen|DRUG: Gabapentin|DRUG: Acetaminophen|DRUG: Methocarbamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib Tosylate and Stereotactic Radiosurgery in Treating Patients With Brain Metastases
Status: COMPLETED
Conditions: Tumors Metastatic to Brain
Interventions: DRUG: sorafenib tosylate|RADIATION: stereotactic radiosurgery|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT of Antioxidant Therapy to Prevent Preeclampsia in Brazil
Status: COMPLETED
Conditions: Preeclampsia|Eclampsia|HELLP Syndrome|Pregnancy
Interventions: DRUG: Vitamin C and E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: CT in Diagnosing Patients With Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: PROCEDURE: computed tomography|PROCEDURE: 4-dimensional computed tomography|PROCEDURE: computed tomography|PROCEDURE: cone-beam computed tomography|PROCEDURE: cone-beam computed tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Gotistobart|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic/Pharmacodynamic Study of Doripenem in Febrile Neutropenic Patients
Status: COMPLETED
Conditions: Febrile Neutropenia
Interventions: DRUG: Doripenem|DRUG: doripenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Perifosine in Patients With Relapsed/Refractory Waldenström's Macroglobulinemia
Status: COMPLETED
Conditions: Waldenström's Macroglobulinemia
Interventions: DRUG: Perifosine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Two Low-shrinkage Composites
Status: COMPLETED
Conditions: Tooth Diseases
Interventions: DEVICE: Restorative materials- Filtek Silorane|DEVICE: Restorative materials-Kalore|DEVICE: Preparation-Er,Cr:YSGG Laser|DEVICE: Preparation- Diamond Bur
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VIP: Vascular Imaging Project. Study on the Progression of Cardiovascular Disease in Renal Transplant Recipients
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DRUG: AUC monitored withdrawal of MMF or CNI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Neonatal Jaundice With Filtered Sunlight Phototherapy: Safety and Efficacy in African Neonates
Status: COMPLETED
Conditions: Jaundice, Neonatal
Interventions: DEVICE: Filtered-sunlight phototherapy|DEVICE: Conventional phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Femoral Triangle Block Versus Adductor Canal Block in Arthroscopic Anterior Cruciate Ligament Reconstruction
Status: RECRUITING
Conditions: Femoral Triangle Block|Adductor Canal Block|Anterior Cruciate Ligament Reconstruction
Interventions: OTHER: Femoral Triangle Block|OTHER: Adductor Canal Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Efficacy of Intravenous Infusion of Autologous MSC_Apceth for the Treatment of Critical Limb Ischemia
Status: COMPLETED
Conditions: Critical Limb Ischemia|Peripheral Artery Disease
Interventions: BIOLOGICAL: PTA + Infusion of MSC_Apceth|PROCEDURE: PTA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 12 / 48 Week Pivotal PFT vs PBO in COPD I
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Olodaterol (BI1744)|DRUG: Olodaterol (BI1744)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Potential Use of Nebulized Hydroxychloroquine for the Treatment of COVID-19
Status: UNKNOWN
Conditions: 2019 Novel Coronavirus
Interventions: DRUG: HCQ01|OTHER: standard of care (SOC) for COVID-19
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Effects of Ketamine vs Placebo With Venlafaxine in Severe Depression Patients
Status: NOT_YET_RECRUITING
Conditions: Major Depressive Episode
Interventions: DRUG: Ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Stem Cell Transplantation in CML With Partial T Cell Depletion
Status: UNKNOWN
Conditions: Philadelphia Chromosome-positive Chronic Myelocytic Leukemia
Interventions: PROCEDURE: Stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incorporating MR Imaging Into Prostate Radiotherapy Treatment Planning
Status: COMPLETED
Conditions: Prostate Cancer|Adenocarcinoma of the Prostate Stage I|Adenocarcinoma of the Prostate Stage II|Adenocarcinoma of the Prostate Stage III
Interventions: DEVICE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neural Effects of Mindfulness Training on Attention
Status: COMPLETED
Conditions: No Condition|Focus is Neural Effects of Mindfulness Training on Attention
Interventions: BEHAVIORAL: Mindfulness Meditation Training (MMT)|BEHAVIORAL: Nutrition Education course
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dose Finding Study in Colorectal Cancer Patients Receiving 5-FU-based Chemotherapy to Assess the Efficacy of Elsiglutide in the Prevention of Chemotherapy Induced Diarrhea (CID)
Status: COMPLETED
Conditions: Drug and/or Toxin-induced Diarrhea
Interventions: DRUG: Elsiglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Identification of de Novo Fanconi Anemia in Younger Patients With Newly Diagnosed Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Childhood Acute Erythroleukemia (M6)|Childhood Acute Megakaryocytic Leukemia (M7)|Childhood Acute Minimally Differentiated Myeloid Leukemia (M0)|Childhood Acute Monoblastic Leukemia (M5a)|Childhood Acute Monocytic Leukemia (M5b)|Childhood Acute Myeloblastic Leukemia With Maturation (M2)|Childhood Acute Myeloblastic Leukemia Without Maturation (M1)|Childhood Acute Myelomonocytic Leukemia (M4)|Childhood Myelodysplastic Syndromes|Chronic Myelomonocytic Leukemia|de Novo Myelodysplastic Syndromes|Fanconi Anemia|Refractory Anemia|Refractory Anemia With Excess Blasts|Refractory Anemia With Excess Blasts in Transformation|Refractory Anemia With Ringed Sideroblasts|Secondary Myelodysplastic Syndromes|Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies
Interventions: OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Short-term Impact of Cyplexinol® on Self-reported Joint Pain
Status: COMPLETED
Conditions: Joint Pain
Interventions: DIETARY_SUPPLEMENT: Cyplexinol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE