pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety of Clofarabine With Multiagent Chemotherapy in Childhood Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoid Leukemia Relapse|Acute Lymphoid Leukemia Relapse After Bone Marrow Transplant
Interventions: DRUG: Clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ARomatherapy for Cognitive Trajectory in Chinese After Coronary Artery Bypass Grafting
Status: UNKNOWN
Conditions: Coronary Artery Bypass Grafting|Myocardial Infarction
Interventions: DRUG: Aromatherapy|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Propranolol on the Encoding and Retrieval of Emotional Material After Single Dose Administration in Healthy Young Subjects
Status: COMPLETED
Conditions: Memory|Heart Rate|Skin Electric Conductance|Amylase|Propanolol
Interventions: DRUG: propranolol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Magnesium Sulfate to Prevent Hospitalisation of Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Status: WITHDRAWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Magnesium Sulfate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of Descemet Membrane Transplantation for the Treatment of Fuchs' Endothelial Dystrophy
Status: UNKNOWN
Conditions: Fuchs' Endothelial Dystrophy
Interventions: OTHER: Descemet Membrane Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Folic Acid Supplementation in Phenytoin Induced Gingival Overgrowth
Status: COMPLETED
Conditions: Gingival Overgrowth
Interventions: DRUG: folic acid|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Laboratory-Treated Autologous Lymphocytes, Aldesleukin, and GM-CSF in Treating Patients With Recurrent, Refractory, or Metastatic Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: EGFRBi-armed autologous activated T cells|BIOLOGICAL: aldesleukin|BIOLOGICAL: sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Cohort Study of Neoadjuvant Therapy With Sintilimab (PD-1 Inhibitor) Combined With Chemotherapy in Resectable ESCC
Status: ENROLLING_BY_INVITATION
Conditions: Resectable Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Sintilimab (PD-1 inhibitor)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: APOSTrophe Study (Parenteral Nutrition and Bone Trophicity) Impact of a Long-term Parenteral Nutrition on Bone Metabolism Measured by High Resolution Peripheral Quantitative Computer Tomography (HR-pQCT) in Children and Young Adults
Status: COMPLETED
Conditions: Long-term Parenteral Nutrition (2 Years) in Children and Adults
Interventions: DEVICE: HR-pQCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Revisional Surgery After 925 OAGB[One Anastomosis Gastric Bypass] Operations Retrospective Cohort Study of the UK MGB/OAGB Collaborative Group.
Status: COMPLETED
Conditions: Revisions After MGB/OAGB|Morbidities|Morality
Interventions: PROCEDURE: MGB/OAGB
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Tolerability, Safety, Pharmacokinetics, and Antitumor Activity of Loncastuximab Tesirine in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated Diffuse Large B-cell Lymphoma (LOTIS-8)
Status: WITHDRAWN
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Loncastuximab tesirine|DRUG: Prednisone|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Follow-up of Anal Fistulae in Crohn's Disease Treated With Anti-TNFalpha and Interest of New MRI Sequences
Status: COMPLETED
Conditions: Anal Fistula|Crohn's Disease
Interventions: OTHER: Pelvis Magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CSF CTC-Capture-Guided EGFR-TKI and Bevacizumab Combination Therapy in EGFR-Mutant Advanced NSCLC
Status: NOT_YET_RECRUITING
Conditions: Non Small Cell Lung Cancer|Circulating Tumor Cell|EGF-R Positive Non-Small Cell Lung Cancer
Interventions: DRUG: Osimertinib 80 MG|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Depression Using a Mobile Application in the Dominican Republic
Status: TERMINATED
Conditions: Depression Mild|Depression Moderate
Interventions: BEHAVIORAL: El Buen Consejo Móvil- Group (EBCM-G)|BEHAVIORAL: El Buen Consejo Móvil- Individual (EBCM-I)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combining Physiotherapy Group Exercise With Acceptance and Commitment Therapy in Elderly With Chronic Low Back Pain
Status: RECRUITING
Conditions: Chronic Low Back Pain
Interventions: BEHAVIORAL: GrExPACT|BEHAVIORAL: GrEx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Iterative Design of Custom Dynamic Orthoses to Reduce Articular Contact Stress
Status: COMPLETED
Conditions: Ankle Fractures|Post-traumatic Osteoarthritis|Osteoarthritis Ankle
Interventions: DEVICE: Custom Carbon Fiber Dynamic Orthosis (CDO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study of Herceptin (Trastuzumab) in Combination With Cisplatin/Capecitabine Chemotherapy in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Gastric or Gastro-Esophageal Junction Cancer
Status: TERMINATED
Conditions: Gastric Cancer
Interventions: DRUG: Capecitabine|DRUG: Cisplatin|DRUG: Herceptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intense Regulated Pulsed Light Vs Standard of Care for the Treatment of Meibomian Gland Dysfunction
Status: SUSPENDED
Conditions: Meibomian Gland Dysfunction
Interventions: DEVICE: E>Eye IRPL|DEVICE: Warm compress
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Tiotropium on the Cough Reflex in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Chronic Bronchitis
Interventions: DRUG: Tiotropium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short-term Effects of Humidification Devices on Respiratory Pattern and Work of Breathing During Invasive Ventilation
Status: COMPLETED
Conditions: Chronic Respiratory Failure
Interventions: DEVICE: Hygrovent Gold|DEVICE: Heated and moisture exchanger (HME)|DEVICE: Heated humidifier (HH)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Safety and Immunogenicity of DTP/Hepatitis B 10ug Hib Vaccine (Bio Farma)
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: DPT/HepatitisB/Hib vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase II Study of Venetoclax in Combination With Dose-adjusted EPOCH-R or R-CHOP for Patients With Richter's Syndrome
Status: RECRUITING
Conditions: Richter Syndrome
Interventions: DRUG: Venetoclax|OTHER: DA-EPOCH-R|OTHER: R-CHOP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD
Status: RECRUITING
Conditions: Depression|Pain|Cognitive Impairment
Interventions: BEHAVIORAL: PATH-Pain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Lolland-Falster Health Study
Status: UNKNOWN
Conditions: Impaired Health|Disease|Wellbeing|Mental Disorders|Atherosclerosis|Renal Insufficiency, Chronic|Skin Diseases|Urinary Incontinence|Personality|Coronary Disease|Ear Diseases|Nose Diseases|Pharyngeal Diseases|Chronic Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Filgrastim, Cladribine, Cytarabine, and Mitoxantrone Hydrochloride in Treating Patients With Newly Diagnosed or Relapsed/Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Acute Biphenotypic Leukemia|de Novo Myelodysplastic Syndrome|Previously Treated Myelodysplastic Syndrome|Recurrent Adult Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia
Interventions: DRUG: Cladribine|DRUG: Cytarabine|BIOLOGICAL: Filgrastim|OTHER: Laboratory Biomarker Analysis|DRUG: Mitoxantrone Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pregnancy and Congenital Toxoplasmosis
Status: RECRUITING
Conditions: Congenital Toxoplasmosis|Retinochoroiditis
Interventions: OTHER: Estimation of the occurrence of retinochoroiditis in women with congenital toxoplasmosis and previous retinochoroiditis lesions (recurrence) during pregnancy and postpartum.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prospective Evaluation of Xerava Prophylaxis in Hematological Malignancy Patients With Prolonged Neutropenia
Status: RECRUITING
Conditions: Hematological Malignancy|Neutropenia
Interventions: DRUG: Eravacycline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Computerized Intervention for Amelioration of Cognitive Late Effects Among Childhood Cancer Survivors
Status: COMPLETED
Conditions: Brain Tumor|Acute Lymphoblastic Leukemia
Interventions: BEHAVIORAL: Computerized working memory training program (intervention)|BEHAVIORAL: Computerized working memory training program (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation Intervention to Prevent Adverse Events Related to Androgen-deprivation Therapy (ADT) in Patients With Metastatic Prostate Cancer (PCa): a Single Arm Feasibility Study (ReCaP Study)
Status: RECRUITING
Conditions: Metastatic Prostate Cancer (PCa) in ADT|Rehabilitation
Interventions: PROCEDURE: rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Clinical Trial to Examine the Efficacy of a Dietary Supplement to Improve the Health and Appearance of Hair.
Status: ACTIVE_NOT_RECRUITING
Conditions: Hair Thinning|Hair Shedding
Interventions: DIETARY_SUPPLEMENT: Scale HLV Clinical Formula Hair Vitamins|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Confirm the Safety and Efficacy of Tegoprazan in Patients With Healed Erosive Esophagitis
Status: COMPLETED
Conditions: Healed Erosive Esophagitis
Interventions: DRUG: Tegoprazan 25mg QD|DRUG: Lansoprazole 15mg QD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Efficacy, Safety, and Immunogenicity of Gam-COVID-Vac Vaccine Against COVID-19
Status: UNKNOWN
Conditions: Covid19 Prevention
Interventions: BIOLOGICAL: Gam-COVID-Vac|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study on the Treatment of Elevated Total Bilirubin in Primary Biliary Cholangitis With Baobao Dan Capsule
Status: NOT_YET_RECRUITING
Conditions: Primary Biliary Cholangitis
Interventions: DRUG: Babaodan Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internal Mammary Lymph Nodes Irradiation in High-risk Breast Cancer After Neoadjuvant Chemotherapy
Status: RECRUITING
Conditions: Breast Cancer
Interventions: RADIATION: internal mammary nodal irradiation|RADIATION: No internal mammary node irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MGC018 in Combination With MGD019 in Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Castration-Resistant Prostatic Cancer|Malignant Melanoma|Pancreatic Ductal Carcinoma|Hepatocellular Cancer|Epithelial Ovarian Cancer|Renal Cell Carcinoma
Interventions: BIOLOGICAL: vobramitamab duocarmazine|BIOLOGICAL: lorigerlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Web-Based Intervention for Bulimia Nervosa
Status: COMPLETED
Conditions: Bulimia Nervosa
Interventions: OTHER: Selfapy for Bulimia Nervosa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fronto-limbic Functional Connectivity Via Real-time fMRI Neurofeedback
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Real-time fMRI neurofeedback from Turbo Brain voyager (TBV) 3.2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness and Safety of Semaglutide Combined With Dietary Fiber (Soloways) in Adults With Overweight or Obesity
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: Fiber Supplement Group|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bleach and Urine Color in UC Patients Using 5ASA
Status: ACTIVE_NOT_RECRUITING
Conditions: Ulcerative Colitis
Interventions: OTHER: Adding household bleach to urine sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fecal Microbial Transplantation in Critically Ill Patients With Severe Infections.
Status: RECRUITING
Conditions: Sepsis|Infections
Interventions: DRUG: fecal bacteria solution|DRUG: physiological saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Solution-Oriented Approach on Psychosocial Health, Fear of Childbirth and Postnatal Senses of Security
Status: COMPLETED
Conditions: Fear of Childbirth|Psychosocial Health|Pregnancy|Postpartum|Childbirth
Interventions: OTHER: Solution-Oriented Approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Extracellular Fluid in Resistant Hypertension
Status: TERMINATED
Conditions: Hypertension
Interventions: DRUG: Cardura XL 4 mg bd|DRUG: Amiloride 5 mg bd|DRUG: Furosemide 40 mg bd
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-human, Safety, Tolerability and Pharmacokinetics Study of LRX712 in Osteoarthritic Patients
Status: COMPLETED
Conditions: Patients With Moderate Knee Osteoarthritis (30 - 65 Years)
Interventions: DRUG: LRX712|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trabedersen (OT-101) With Pembrolizumab for Newly Diagnosed Advanced NSCLC and Positive PD-L1
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Trabedersen|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ALT-801 DDI Study in Healthy Volunteers
Status: COMPLETED
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: DRUG: ALT-801|DRUG: Metformin|DRUG: Atorvastatin|DRUG: Warfarin|DRUG: Digoxin|DRUG: Ethinylestradiol and Levonorgestrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Transcranial Magnetic Stimulation (TMS) in Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DEVICE: DEEP TMS H1 coil|DEVICE: Deep H1 coil TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Arrhythmic Mitral Valve Prolapse Detection Using Long-term Ambulatory Rhythm Monitoring
Status: RECRUITING
Conditions: Mitral Valve Prolapse|Ventricular Arrythmia
Interventions: DIAGNOSTIC_TEST: 14-day rhythm monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Short Interval Resveratrol Trial in Cardiovascular Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2|Coronary Artery Disease
Interventions: DIETARY_SUPPLEMENT: Trans-resveratrol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: High Versus Lower Intensity Surveillance Following Resection of Retroperitoneal Sarcoma
Status: NOT_YET_RECRUITING
Conditions: Sarcoma,Soft Tissue|Sarcoma Retroperitoneal
Interventions: DIAGNOSTIC_TEST: High-intensity radiological surveillance|DIAGNOSTIC_TEST: Lower-intensity radiological surveillance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation Of Sperm Production With Healthy Male Volunteers Receiving Lyrica Or Placebo
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Rosiglitazone to Reverse Metabolic Defects in Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type II|Insulin Resistance
Interventions: PROCEDURE: Exercise cardiopulmonary metabolic testing|PROCEDURE: Skeletal muscle biopsy|PROCEDURE: Brachial artery reactivity testing
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of Wireless Transmission of Invasive Blood Pressure Signal
Status: COMPLETED
Conditions: Multiple Trauma|Shock|Atrial Fibrillation|Perioperative/Postoperative Complications
Interventions: DEVICE: Wireless invasive blood pressure monitoring (Hybymed® Wireless IBPM System)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CPX-351 Plus Enasidenib for Relapsed AML
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Acute Myeloid Leukemia
Interventions: DRUG: Enasidenib Mesylate|DRUG: Liposome-encapsulated Daunorubicin-Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Proof of Concept, Window Trial of the IMmunological Effects of AveLumab and Aspirin in Triple-Negative Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: Avelumab|DRUG: Aspirin|DRUG: Lansoprazole (Proton Pump Inhibitor)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of the HS-25 Combination With Atorvastatin in Subjects With Hypercholesterolemia in Coronary Heart Diseases
Status: COMPLETED
Conditions: Hypercholesterolemia in Coronaory Heart Disease
Interventions: DRUG: HS-25 and Atorvastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DESIVI: Dosing of Electrical Stimulation in Venous Insufficiency
Status: COMPLETED
Conditions: Varicose Veins|Venous Stasis|Venous Insufficiency
Interventions: DEVICE: Revitive IX Neuromuscular Stimulation Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Cyclobenzaprine for Treatment of Sleep Disturbance in Aromatase Inhibitor-treated Breast Cancer Patients
Status: TERMINATED
Conditions: Sleep Initiation and Maintenance Disorders|Pain
Interventions: DRUG: Cyclobenzaprine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ambroxol as a Novel Disease Modifying Treatment for Lewy Body Dementia
Status: NOT_YET_RECRUITING
Conditions: Lewy Body Disease
Interventions: DRUG: Ambroxol Hydrochloride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Investigate the Efficacy and Safety of Individualized Doses of BioChaperone Insulin Lispro in Comparison to Humalog® U-100 in Patients With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: BioChaperone insulin lispro|DRUG: Humalog®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First in Human Study of T3P-Y058-739 (T3P)
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: Pembrolizumab+T3P-Y058-739|DRUG: T3P-Y058-739 (IV)|DRUG: T3P-Y058-739 (IT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety/ Feasibility of Percutaneous Administration of Vonapanitase as Monotherapy for Peripheral Artery Disease (PAD) of the SFA and Popliteal Arteries
Status: WITHDRAWN
Conditions: Peripheral Artery Disease
Interventions: DRUG: vonapanitase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rechallenge of Cetuximab Combined With Irinotecan as Third-line Chemotherapy in Patients With Metastatic Colorectal Cancer - Phase II Study
Status: TERMINATED
Conditions: Colorectal Cancer Metastatic
Interventions: DRUG: cetuximab|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet-Based Behavioural Parent Training Intervention for Children With Attention Deficit/Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: BEHAVIORAL: Internet-based behavioral parent training (I-BPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cryoneurolysis for TKA - a Pilot Study
Status: RECRUITING
Conditions: Knee Pain Chronic|Osteoarthritis
Interventions: DEVICE: Iovera - Cryoneurolysis|DRUG: Local anesthetic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Blow Bottle Verses ACBTs Technique in Patients of Chronic Obstructive Pulmonary Disease
Status: RECRUITING
Conditions: COPD
Interventions: DEVICE: BLOW BOTTLE|OTHER: ACBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension
Status: COMPLETED
Conditions: Sickle Cell Anemia|Pulmonary Hypertension
Interventions: DRUG: Nitric Oxide|DEVICE: INO Pulse - NO Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Biomarkers of Muscle Anabolism (MK-0000-082)
Status: COMPLETED
Conditions: Muscle Anabolism
Interventions: DRUG: Comparator: low dose testosterone|DRUG: Comparator: high dose testosterone|DRUG: Comparator: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Quality of Life Measures After Single Access Vs Conventional Laparoscopic Cholecystectomy: Prospective Randomized Study.
Status: COMPLETED
Conditions: Evidence of Cholecystectomy
Interventions: PROCEDURE: surgery|OTHER: SURGERY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Home Based Child Care to Reduce Mortality and Malnutrition in Tribal Children of Melghat, India: CRCT
Status: COMPLETED
Conditions: Acute Respiratory Tract Infections|Diarrhea|Malaria|Neonatal Sepsis|Birth Asphyxia
Interventions: OTHER: Home based child care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Treatment and Control of Atopic Dermatitis With 0.03% Tacrolimus Ointment
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: tacrolimus ointment|DRUG: Placebo ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Potential Vitamin D Effects on Muscle: a Pilot Study
Status: COMPLETED
Conditions: Dysphagia|Fecal Incontinence|Urinary Incontinence
Interventions: OTHER: Ergocalciferol (vitamin D2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Theater in School Sex Education - a Randomized Controlled Study
Status: COMPLETED
Conditions: Attitude|Sexual Behavior|Condom Use|Prevention|Chlamydia Infections|Safe Sex
Interventions: BEHAVIORAL: SAFETY|BEHAVIORAL: Standard education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: IMaging Pilot Study of the αvβ6 Integrin Radiotracer [18F]-A20FMDV2 in PAtients With Solid Cancer Types
Status: COMPLETED
Conditions: Cancer
Interventions: PROCEDURE: PET Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessing Safety and Efficacy of DE-089 Ophthalmic Solution in Patients With Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: Placebo ophthalmic solution and 3% DE-089 ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Minimally Invasive Ilium Osteotomy and Its Bone Repairing Effect
Status: RECRUITING
Conditions: Control Group
Interventions: PROCEDURE: Traditional iliac crest bone harvesting surgery|PROCEDURE: Minimally invasive bone harvesting surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Renin Angiotensin System Blockage (RAS) Blockade On PTX3 Levels In Diabetic Patients With Proteinuria
Status: COMPLETED
Conditions: Diabetes|Proteinuria|Renin Angiotensin System
Interventions: DRUG: ramipril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: Computerized Cognitive Bias Intervention for Intolerance of Uncertainty
Status: COMPLETED
Conditions: Intolerance of Uncertainty; Anxiety
Interventions: BEHAVIORAL: Active IU CBM-I|BEHAVIORAL: Control CBM-I
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Implantation of Two Multifocal Intraocular Lenses in the Treatment of Senile Cataract
Status: UNKNOWN
Conditions: Senile Cataract
Interventions: BIOLOGICAL: Acri.LISA366D multifocal aspheric IOLs|BIOLOGICAL: TecnisZ9001 multifocal aspheric IOLs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Rehabilitation Programs in Patients With Mild to Moderate Parkinson's Disease.
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: OTHER: Asymmetric Motor Strengthening|OTHER: Conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: VELCADE® (Bortezomib) With Rituximab in Subjects With Relapsed or Refractory Indolent B-Cell Lymphoma
Status: COMPLETED
Conditions: B-Cell Lymphoma|Follicular Lymphoma|Marginal Lymphoma
Interventions: DRUG: VELCADE and rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study To Investigate The Relative Bioavailability of OZ439 Formulations In Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: OZ439 mesylate 800mg Powder in Bottle for Oral Suspension|DRUG: OZ439 mesylate 400mg Prototype Solution Formula 1|DRUG: OZ439 mesylate 800mg Prototype Solution Formula 1|DRUG: OZ439 mesylate 800mg Prototype Solution Formula 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pudendal Nerve Mapping Towards Improved Neuromodulation for Urinary Retention
Status: COMPLETED
Conditions: Urinary Retention|Underactive Bladder
Interventions: DEVICE: Participants received a Neurostimulator, which was used to map the pudendal nerve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vitamin D Supplementation in HIV Youth
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Vitamin D control dose|DRUG: Vitamin D supplementation-
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CPR Rescuer Fatigue on Chest Compression Effectiveness
Status: COMPLETED
Conditions: Rescuer Fatigue During CPR
Interventions: OTHER: Chest compression on adult and pedi manikins|OTHER: Use of stepstool during chest compressions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Compare PK and Bioavailability of 2 NP101 Patches With Oral Imitrex in Healthy Adults
Status: COMPLETED
Conditions: Compare Bioequivalence Patches Previously Used in the NP101-007 Study
Interventions: DRUG: NP101|DRUG: sumatriptan succinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Opioid-free Anesthesia on Sleep Quality, Cognitive Function and Recovery Quality After General Anesthesia in Elderly Patients
Status: NOT_YET_RECRUITING
Conditions: Opioid-Free Anesthesia|POCD|Recovery Quality|Sleep Quality
Interventions: DRUG: Opioid-free Analgesics|DRUG: Opioid group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized Recommendations for Acute Kidney Injury (AKI) Care
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: OTHER: Kidney Action Team Recommendations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Assess the Effect of Diets With Different Protein Composition - Mainly Coming From Lean Red Meat - in Body Weight and Lipid Profile in Overweight and Obese Women
Status: COMPLETED
Conditions: Weight Loss|Obesity|Overweight|Diet, Reducing|Lipids
Interventions: BEHAVIORAL: Weight loss interventional study with 20% protein-diet|BEHAVIORAL: Weight loss interventional study with 27% protein-diet|BEHAVIORAL: Weight loss interventional study with 35% protein-diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy With or Without Chemotherapy in Treating Patients With Advanced Cancer of the Larynx
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: chemotherapy|DRUG: cisplatin|DRUG: fluorouracil|PROCEDURE: conventional surgery|RADIATION: low-LET cobalt-60 gamma ray therapy|RADIATION: low-LET electron therapy|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Trial of Low Field Magnetic Stimulation Augmentation of Antidepressant Therapy in Treatment-Resistant Depression
Status: COMPLETED
Conditions: Treatment Resistant Depression
Interventions: DEVICE: Low Field Magnetic Stimulation (LFMS)|DEVICE: Sham LFMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pertubation With Lignocaine in Endometriosis
Status: COMPLETED
Conditions: Endometriosis|Dysmenorrhea
Interventions: DRUG: Lignocaine|DRUG: Ringers Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Advance Provision of Medication Abortion
Status: WITHDRAWN
Conditions: Early Abortion
Interventions: DRUG: Mifeprex® (Mifepristone 200 mg)|DRUG: Misoprostol 800 mcg|DRUG: ella® (ulipristal acetate emergency contraception 30 mg)|DIAGNOSTIC_TEST: AccuHome® Pregnancy OTC Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Tablet-based Interactive Games in Elderly With Cognitive Impairment and Persons With Intellectual Disability
Status: COMPLETED
Conditions: Technology|Cognitive Impairments|Intellectual Disability
Interventions: DEVICE: Tablet-based interactive games experimental group intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Efficacy of Reminders to Complete HPV Series
Status: COMPLETED
Conditions: Completion of Three Dose Series of HPV|Improvement in Vaccine Intervals Between HPV Doses
Interventions: OTHER: Telephone reminder|OTHER: Text Message reminder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: imPROving Quality of LIFe In the Long COVID Patient
Status: RECRUITING
Conditions: Post-COVID-19 Syndrome|Long COVID|Long Covid19|COVID-19|POTS - Postural Orthostatic Tachycardia Syndrome|Post COVID-19 Condition|Post-COVID Syndrome|Post COVID-19 Condition, Unspecified|Postinfectious Inflammation|Postinfectious Disorder
Interventions: DRUG: Nirmatrelvir/ritonavir|DRUG: Placebo/ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erlotinib Intercalated With Chemotherapy Versus Erlotinib as First Line Treatment in Stage IIIB/IV NSCLC Patients With EGFR Mutation
Status: UNKNOWN
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: gemcitabine; cisplatin or carboplatin; erlotinib|DRUG: erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of SCID Due to ADA Deficiency With Autologous Transplantation of Cord Blood or Hematopoietic CD 34+ Cells After Addition of a Normal Human ADA cDNA by the EFS-ADA Lentiviral Vector
Status: COMPLETED
Conditions: Adenosine Deaminase Deficiency|ADA-SCID
Interventions: GENETIC: Lentiviral Gene Transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of Etrolizumab in Participants With Ulcerative Colitis Who Have Been Previously Exposed to Tumor Necrosis Factor (TNF) Inhibitors
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Etrozulimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Levetiracetam in Post-Traumatic Stress Disorder
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: DRUG: levetiracetam|DRUG: Placebo|DRUG: Levetriracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BiRd vs. Rd as Initial Therapy in Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Clarithromycin|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiological Effects of Non-invasive Mechanical Ventilation Versus High-flow Nasal Cannula in Critically Ill Patients at High Risk of Extubation Failure
Status: UNKNOWN
Conditions: Weaning From Mechanical Ventilation
Interventions: DEVICE: Non-invasive ventilation (NIV)|DEVICE: High-flow nasal cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Intraoral Transcutaneous Electrical Nerve Stimulation in Orthodontics Pain
Status: NOT_YET_RECRUITING
Conditions: Orthodontic Appliance|Pain|Transcutaneous Electric Nerve Stimulation|Orthodontic Appliance Complication
Interventions: DEVICE: Active TENS Device|DEVICE: Intervention 2: Placebo/Sham Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Of CP-751,871 In Combination With Exemestane In Postmenopausal Women With Hormone Receptor Positive Advanced Breast Cancer
Status: TERMINATED
Conditions: Breast Neoplasms
Interventions: DRUG: CP-751,871|DRUG: exemestane|DRUG: exemestane|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet Hyperreactivity to Aspirin and Stroke
Status: COMPLETED
Conditions: Stroke|Cerebral Infarction|Cardiovascular Diseases|Vascular Diseases|Atherosclerosis|Ischemia|Thrombosis|Acute Coronary Syndrome
Interventions: DRUG: Aspirin (platelet sensitive versus platelet hyperreactivity)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Biomarkers in Tissue Samples From Patients With Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: GENETIC: cytogenetic analysis|GENETIC: microarray analysis|GENETIC: mutation analysis|OTHER: immunohistochemistry staining method|OTHER: immunologic technique|OTHER: mass spectrometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Monitoring Brain Waves in Response to Visual and/or Auditory Stimulation in Parkinson's Disease Patients
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: BEHAVIORAL: Baseline|BEHAVIORAL: visual stimuli|BEHAVIORAL: Auditory stimuli|BEHAVIORAL: Visual and auditory stimuli
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Dynamic Surface Exercise Training on Trunk Control and Gross Motor Functions in Children With Diplegic Cerebral Palsy
Status: ACTIVE_NOT_RECRUITING
Conditions: Cerebral Palsy Spastic Diplegia
Interventions: OTHER: Dynamic surface exercise training|OTHER: conventional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: REACH Hope Intervention for Dementia and TBI Caregivers
Status: ACTIVE_NOT_RECRUITING
Conditions: Dementia, Mixed|Dementia of Alzheimer Type|TBI (Traumatic Brain Injury)
Interventions: OTHER: REACH Hope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel, Topotecan, and Cisplatin in Treating Patients With Advanced, Persistent, or Recurrent Cervical Cancer
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: DRUG: cisplatin|DRUG: paclitaxel|DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KITS Study -Ketorolac In Tonsillectomy Surgery: a Double Blinded, Randomized Clinical Trial
Status: TERMINATED
Conditions: Recurrent Acute Tonsillitis
Interventions: DRUG: Ketorolac|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Alzheimer Disease|Cognitive Impairment|Cognitive Decline|Memory Loss|Memory Impairment
Interventions: BEHAVIORAL: Moderate Intensity Continuous Training (MICT)|BEHAVIORAL: Chair-based Stretch|BEHAVIORAL: High-Intensity Interval Training (HIIT)|BEHAVIORAL: Combined Aerobic Resistance Exercise (CARE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Novel Axillary Lymph Node Ink Localization Technique: A Feasibility Study
Status: WITHDRAWN
Conditions: Breast Cancer|Axillary Lymphadenitis
Interventions: DEVICE: Black-Eye Ink
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Thyroid Hormone Therapy on Muscle Mass and Function in Older Adults With Subclinical Hypothyroidism
Status: COMPLETED
Conditions: Subclinical Hypothyroidism|Sarcopenia
Interventions: DRUG: Levothyroxin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Posterior Capsular Injection With Femoral Nerve Block for Total Knee Arthroplasty
Status: COMPLETED
Conditions: Posterior Knee Infiltration
Interventions: DRUG: Ropivacaine with Epinephrine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Kidney Transplants in Hepatitis C Negative Recipients With Hepatitis C Viremic Donors
Status: COMPLETED
Conditions: End Stage Renal Disease|Hepatitis C
Interventions: DRUG: Glecaprevir/pibrentasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Genetic Influencing Factors on Clozapine Pharmacokinetics
Status: COMPLETED
Conditions: CYP1A2 Polymorphism|CYP2C19 Polymorphism|Clozapine|Schizophrenia
Interventions: OTHER: Determination of plasma concentration of clozapine/ Genotyping
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Influence of Probiotics on the Immunologic Response to Vaccinations in Infants
Status: UNKNOWN
Conditions: Immunity|Measles|Mumps|Rubella
Interventions: DIETARY_SUPPLEMENT: Probiotics (L.acidophilus and B.lactis)|DIETARY_SUPPLEMENT: Cornflor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION