pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Copanlisib Plus Ibrutinib or Acalabrutinib in R/R CLL
Status: WITHDRAWN
Conditions: Chronic Lymphocytic Leukemia (CLL)
Interventions: DRUG: Ibrutinib|DRUG: Copanlisib|DRUG: Acalabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fertility Sparing Therapy for Patients With Stage IA G2 Endometrial Cancer
Status: NOT_YET_RECRUITING
Conditions: Carcinoma, Endometrioid|Fertility Preservation
Interventions: DRUG: Treatment Option 1 is a single-drug regimen, with oral medroxyprogesterone acetate (MPA) 500mg/d or MA 320mg/d.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Systemic Chemotherapy Plus PD-1 Inhibitor in Combination With Bevacizumab in Gastric Cancer With Peritoneal Metastasis
Status: ENROLLING_BY_INVITATION
Conditions: Gastric Cancer Peritoneal Metastases
Interventions: DRUG: albumin-bound paclitaxel (260 mg/m2, d1)|DRUG: S-1|DRUG: sintilimab|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resistance Band Training Versus Nordic Hamstring Exercise on Hamstring Strength Among Football Players
Status: COMPLETED
Conditions: Intervention|Injury Prevention
Interventions: OTHER: Nordic Hamstring Exercise|OTHER: Hamstring Curl with Resistance band
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Allogeneic Bone Paste Versus Allogeneic Bone Powder
Status: UNKNOWN
Conditions: Bone Resorption|Dental Diseases
Interventions: BIOLOGICAL: BIOBank bone paste|BIOLOGICAL: BIOBank cortico-cancellous bone powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IMPact on Revascularization Outcomes of IVUS Guided Treatment of Complex Lesions and Economic Impact
Status: RECRUITING
Conditions: Atherosclerosis
Interventions: DEVICE: Eagle Eye Platinum digital IVUS catheter with optional SyncVision|DEVICE: Resolute Onyx Drug Eluting Stent|DEVICE: Onyx Frontier Drug Eluting Stent|DEVICE: Onyx TruStar Drug Eluting Stent|DEVICE: Onyx TruCor Drug Eluting Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Addition of Montelukast to Fluticasone in the Treatment of Perennial Allergic Rhinitis
Status: TERMINATED
Conditions: Rhinitis, Allergic, Perennial
Interventions: DRUG: Placebo|DRUG: Montelukast|DRUG: Fluticasone propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Caregivers' and Cancer Survivors' Psychological Distress & Symptom Management
Status: COMPLETED
Conditions: Cancer
Interventions: BEHAVIORAL: Handbook|BEHAVIORAL: TIP-C plus Handbook
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Immunologic Responses in HPV-Associated Carcinoma for Patients Receiving Chemoradiation
Status: COMPLETED
Conditions: Head and Neck Cancer|HPV (Human Papillomavirus)-Associated Carcinoma|Oropharyngeal
Interventions: OTHER: research blood draw and tissue biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Robot-assisted Training After Acquired Brain Injury and Disorders of Consciousness
Status: RECRUITING
Conditions: Acquired Brain Injury|Disorders of Consciousness
Interventions: OTHER: GAIT-assisted training|OTHER: STEP-assisted training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: PF-06463922 for Crizotinib Pretreated ROS1 Positive Non-small-cell Lung Cancer
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Lorlatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 12-week Human Trial to Compare the Efficacy and Safety of Polycan on Bone Metabolism
Status: COMPLETED
Conditions: Bone Health in Perimenopausal Women
Interventions: DIETARY_SUPPLEMENT: Polycan|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Take the Reins: The Effects of Nutrient Timing on Cancer-related Fatigue
Status: NOT_YET_RECRUITING
Conditions: Neoplasms|Blood Cancer|Fatigue|Diet Habit|Survivorship|Fasting, Intermittent
Interventions: BEHAVIORAL: Time-restricted eating|BEHAVIORAL: Nutrition counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 4, Vedolizumab-4002 Post-marketing, Disease-Drug-Drug Interaction Study
Status: WITHDRAWN
Conditions: Colitis, Ulcerative|Crohn Disease
Interventions: DRUG: Caffeine|DRUG: Losartan|DRUG: Omeprazole|DRUG: Dextromethorphan|DRUG: Midazolam|DRUG: Vedolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Therapeutic Efficacy of the VRC01 Antibody in Patients Who Initiated Antiretroviral Therapy During Early Acute HIV Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: VRC01|BIOLOGICAL: Placebo for VRC01
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Distress in Phase 1 Trial Caregivers: The P1-CaLL Study
Status: COMPLETED
Conditions: Caregiver Distress
Interventions: BEHAVIORAL: Stress Management and CBT|BEHAVIORAL: Stress Management and Metta-Meditation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Achieving Hybrid Monovision By Paring Monofocal And EDOF Lens Technology
Status: COMPLETED
Conditions: Cataract Senile
Interventions: PROCEDURE: IOL Implantation:EDOF lens|PROCEDURE: IOL Implantation: Monofocal lens
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mineralocorticoid Receptor and Obesity Induced Cardiovascular Complications
Status: COMPLETED
Conditions: Obesity|Insulin Resistance
Interventions: DRUG: Spironolactone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Relative Bioavailability Study of Ramipril 10 mg Capsules Administered Orally as a Sprinkle on Applesauce
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ramipril10 mg Capsules, single dose|DRUG: Atlace® 10 mg capsules, single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: International Normalized Ratio (INR) Normalization in Coumadin Associated Intracerebral Haemorrhage
Status: COMPLETED
Conditions: Intracranial Hemorrhages
Interventions: DRUG: Prothrombin complex concentrate (PCC); fresh frozen plasma (FFP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Treatment, Pharmacogenetics and Glucose Metabolism
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Healthy|Vitamin D Deficiency
Interventions: DRUG: Vitamin D supplementation|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Rosiglitazone and Metformin on Metabolism in Type 2 Diabetes
Status: COMPLETED
Conditions: Insulin Sensitivity|Type 2 Diabetes
Interventions: DRUG: Rosiglitazone|DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clozapine-Augmentation With Ziprasidone or Risperidone, a Randomized, Prospective Trial
Status: COMPLETED
Conditions: Schizophrenia, Schizoaffective Disorder
Interventions: DRUG: ziprasidone|DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ovarian Reserve After Ovarian Torsion
Status: RECRUITING
Conditions: Ovarian Torsion
Interventions: DIAGNOSTIC_TEST: Pre operation Blood sample for AMH|DIAGNOSTIC_TEST: 3 month post operation blood sample for AMH
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Dexlansoprazole Delayed-Release Capsules for Healing of Erosive Esophagitis and Maintenance of Healed Erosive Esophagitis and Relief of Heartburn in Adolescents
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease|Erosive Esophagitis
Interventions: DRUG: Dexlansoprazole|DRUG: Dexlansoprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Compare the Pharmacokinetics of TAH(80/10/12.5) Tablet in Comparison to the Co-administration of Telmisartan, Amlodipine and Hydrochlorothiazide in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: TAH Tablet (Telmisartan80/Amlodipine besylate10/Hydrochlorothiazide12.5)|DRUG: TWYNSTA(Telmisartan+Amlodipine besylate)|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted Anticoagulation Therapy to Reduce Inflammation and Cellular Activation in Long-term HIV Disease
Status: COMPLETED
Conditions: Inflammation|Coagulation|HIV Infection
Interventions: DRUG: Edoxaban 30mg daily|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of SB206 in Subjects With Molluscum Contagiosum
Status: COMPLETED
Conditions: Molluscum Contagiosum
Interventions: DRUG: SB206 4%|DRUG: SB206 8%|DRUG: SB206 12%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of a Parenting Program in Liberia to Improve Parenting, Education, and Health Outcomes for Children in Liberia
Status: COMPLETED
Conditions: Parenting Behavior|Pre-academic and Developmental Skills|Malaria Prevention
Interventions: BEHAVIORAL: Parents Make the Difference
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Kinetic of Immune Memory Response After Re-Vaccination With Meningococcal Vaccine
Status: UNKNOWN
Conditions: Meningococcal Disease; Meningococcal Meningitis
Interventions: BIOLOGICAL: · Meningococcal C conjugate vaccine; Meningococcal A/C Polysaccharide vaccine (partial dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Quetiapine in the Treatment of Patients With Schizophrenia and a Comorbid Substance Use Disorder
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Psychotic Disorder|Substance Abuse|Alcohol Abuse
Interventions: DRUG: Quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase 2a, Open-Label, Two Stage Study of Nerofe or Nerofe With Doxorubicin in Subjects With AML or MDS
Status: WITHDRAWN
Conditions: Acute Myelogenous Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: Nerofe|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Stemchymal® in Acute Liver Failure
Status: WITHDRAWN
Conditions: Stem Cells|Adult Stem Cells|Acute Liver Failure|Acute-On-Chronic Liver Failure|Steminent
Interventions: BIOLOGICAL: Stemchymal®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Propranolol in Newborns With Retinopathy of Prematurity
Status: COMPLETED
Conditions: Retinopathy of Prematurity
Interventions: DRUG: Propranolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Asenapine Treatment for Pediatric Bipolar Disorder (P06107 Has an Extension [P05898; NCT01349907])(P06107)
Status: COMPLETED
Conditions: Bipolar Disorder, Pediatric
Interventions: DRUG: asenapine|DRUG: Placebo to match asenapine|DRUG: Rescue medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Covert Saccade Triggers in Bilateral Vestibular Hypofunction
Status: COMPLETED
Conditions: Reflex, Abnormal|Bilateral Vestibulopathy|Healthy Volunteers
Interventions: OTHER: Covert Saccades and Virtual Reality|OTHER: Actives versus passives Head Impulses|OTHER: Visually guided saccades
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Gemcitabine-Carboplatin Versus Gemcitabine-Oxaliplatin in Cisplatin-unfit Urothelial Carcinoma
Status: UNKNOWN
Conditions: Advanced Urothelial Carcinoma
Interventions: DRUG: GCb|DRUG: GemOx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin C, Vitamin B1 and Steroid in Sepsis
Status: UNKNOWN
Conditions: Sepsis, Severe
Interventions: DRUG: Ascorbic acid-Vitamin B1-Hydrocortisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-surgical Treatment of Peri-implant Mucositis: FMUD vs FMUD and Air-Flow Master Piezon®
Status: COMPLETED
Conditions: Peri-implant Mucositis
Interventions: DEVICE: Glycine powder air polishing|DEVICE: Full mouth ultrasonic debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety of Twice Daily Oxycodone Hydrochloride Controlled-release Tablets in Children Who Completed OTR3001
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Oxycodone hydrochloride controlled-release tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gamma Scintigraphy Study to Investigate Tablet Disintegration in Healthy Volunteers.
Status: TERMINATED
Conditions: Healthy Subjects
Interventions: DRUG: Ibuprofen lysine|DRUG: Ibuprofen Sodium|DRUG: Ibuprofen|DRUG: Ibuprofen (Nurofen)|DRUG: Ibuprofen (Wockhardt)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-Media Imagery Program for Breast Cancer Patients (Phase II)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Envision the Rhythms of Life Program|BEHAVIORAL: Envision the Rhythms of Life Program/Distance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Manganese-Enhanced Magnetic Resonance Imaging in Healthy Volunteers and People With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Mangafodipir (Teslascan)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Peritoneal Carcinomatosis Leveraging ctDNA Guided Treatment in GI Cancer Study (PERICLES Study)
Status: RECRUITING
Conditions: Appendix Carcinoma by AJCC V8 Stage|Colorectal Carcinoma by AJCC V8 Stage|Digestive System Neoplasm|Esophageal Carcinoma by AJCC V8 Stage|Gastric Carcinoma by AJCC V8 Stage|Liver and Intrahepatic Bile Duct Carcinoma|Peritoneal Carcinomatosis
Interventions: PROCEDURE: Biospecimen Collection - blood and tissue sample collection|OTHER: Electronic Health Record Review
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Phase 2 Study to Evaluate the Safety and Efficacy of Clevudine in Patients With Moderate COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Clevudine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase 1, QT/QTC Interval Study in Healthy Subjects
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Lumacaftor|DRUG: Lumacaftor Placebo|DRUG: Ivacaftor|DRUG: Ivacaftor Placebo|DRUG: moxifloxacin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Rapid First-line Genome Sequencing for Prenatal Diagnosis of Congenital Malformations in Comparison With Chromosomal Microarray and Exome Sequencing
Status: RECRUITING
Conditions: Congenital Malformation
Interventions: BIOLOGICAL: foetal amniotic fluid sample|BIOLOGICAL: blood samples|OTHER: semi-structured online interviews
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Segmental Mobilization vs Entire Spine Mobilization In Lumbar Spondylosis
Status: COMPLETED
Conditions: Spondylosis Lumbar
Interventions: OTHER: Entire Spine Mobilization|OTHER: Segmental Mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: RaPiDS- A Phase 2 Study of Anti-PD-1 Independently or in Combination With Anti-CTLA-4 in Second-Line Cervical Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: AGEN2034|DRUG: AGEN1884
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Oxygen Therapy in Treating Patients With Radiation Necrosis of the Brain
Status: UNKNOWN
Conditions: Brain and Central Nervous System Tumors|Cognitive/Functional Effects|Radiation Toxicity
Interventions: DRUG: dexamethasone|DRUG: hyperbaric oxygen|PROCEDURE: cognitive assessment|PROCEDURE: magnetic resonance imaging|PROCEDURE: positron emission tomography|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: SINGLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Performance of Bausch & Lomb ReNu MultiPlus Multi-Purpose Solution in a New Packaging Configuration
Status: COMPLETED
Conditions: Comfort
Interventions: DEVICE: Bausch & Lomb ReNu MultiPlus Multi-Purpose Solution Packaged in the Currently Marketed Resin Bottle.|DEVICE: Bausch & Lomb ReNu MultiPlus Multi-Purpose Solution Packaged in a Clear Resin Bottle.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dabigatran Versus Apixaban in Cerebral Venous Thrombosis
Status: RECRUITING
Conditions: Cerebral Venous Sinus Thrombosis
Interventions: DRUG: Dabigatran Etexilate 150mg|DRUG: Apixaban 5MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Cardiopulmonary and Gaz-exchange Response Between the Six-minute Stepper Test and the Incremental Cardiopulmonary Exercise Testing in Patients With Chronicle Obstructive Pulmonary Disease
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease|Pulmonary Rehabilitation|6-minute Stepper Test
Interventions: OTHER: 2 times : 6-minute stepper test with cardiorespiratory parameters and gaz exchange monitoring (with a rest of 20min between each test).
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: LAG3 PET Imaging in Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Solid Tumor
Interventions: OTHER: 89Zr-DFO-REGN3767|DRUG: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase 3, Multicenter, Open-Label Extension Study of Phenoptin in Subjects With PKU Who Have Elevated Phenylalanine Levels
Status: COMPLETED
Conditions: Phenylketonurias
Interventions: DRUG: sapropterin dihydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Standard Versus Systemic Decolonization Therapy for the Eradication of Methicillin-resistant Staphylococcus Aureus (MRSA) Colonization
Status: COMPLETED
Conditions: Methicillin-resistant Staphylococcus Aureus
Interventions: DRUG: Rifampin|DRUG: Doxycycline|OTHER: 2% mupirocin ointment|OTHER: 4% chlorhexidine gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Staccato Apomorphine (AZ-009) in Patients With Parkinson's Disease Experiencing OFF Episodes
Status: TERMINATED
Conditions: Parkinson Disease
Interventions: DRUG: Apomorphine Cartridge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erlotinib Hydrochloride and Radiation Therapy in Stage III-IV Squamous Cell Cancer of the Head and Neck
Status: TERMINATED
Conditions: Stage III Squamous Cell Carcinoma of the Hypopharynx|Stage III Squamous Cell Carcinoma of the Larynx|Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage III Squamous Cell Carcinoma of the Oropharynx|Stage III Verrucous Carcinoma of the Larynx|Stage III Verrucous Carcinoma of the Oral Cavity|Stage IV Squamous Cell Carcinoma of the Hypopharynx|Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IV Squamous Cell Carcinoma of the Nasopharynx|Stage IV Squamous Cell Carcinoma of the Oropharynx|Stage IV Verrucous Carcinoma of the Larynx|Stage IV Verrucous Carcinoma of the Oral Cavity
Interventions: DRUG: erlotinib hydrochloride|RADIATION: intensity-modulated radiation therapy|OTHER: pharmacogenomic studies|OTHER: gene expression analysis|RADIATION: 3-dimensional conformal radiation therapy|OTHER: biopsy|OTHER: pharmacological study|OTHER: laboratory biomarker analysis|OTHER: questionnaire administration|OTHER: enzyme-linked immunosorbent assay|OTHER: polymorphism analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypoalgesic Effect of Median Nerve Neural Mobilization Compared to a Controlled Group
Status: COMPLETED
Conditions: Cervicobrachial Neuralgia
Interventions: PROCEDURE: Median Nerve Neural Mobilization|DEVICE: Goniometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Cryosurgery and NK Immunotherapy for Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer Metastatic
Interventions: DEVICE: Cryosurgery|BIOLOGICAL: NK Immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Effectiveness of the enVista® Beyond (EY) EDF Intraocular Lens in Subjects Undergoing Cataract Extraction
Status: RECRUITING
Conditions: Cataract
Interventions: DEVICE: enVista EY Beyond IOL|DEVICE: enVista MX60E monofocal IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Safety and Pharmacokinetics of FPA144 in Japanese Patients With Advanced Gastric or Gastroesophageal Cancer
Status: COMPLETED
Conditions: Gastric or Gastroesophageal Cancer
Interventions: DRUG: FPA144
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A First-in-Human Study of Single and Multiple Doses of Amilo-5MER in Healthy Subjects
Status: COMPLETED
Conditions: Inflammatory Disease
Interventions: DRUG: amilo-5MER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inactivated Poliomyelitis Vaccine Made From Sabin Strain
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: Inactivated Poliomyelitis Vaccine Made From Sabin Strain
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mobile Contingency Management for Concurrent Abstinence From Alcohol and Smoking
Status: COMPLETED
Conditions: Smoking Cessation|Alcohol Drinking
Interventions: OTHER: Nicotine Replacement Therapy|DRUG: Bupropion|BEHAVIORAL: Cognitive Behavioral Treatment|BEHAVIORAL: Mobile Contingency Management|BEHAVIORAL: Mobile Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shock-Waves to Treat Fibromyalgia Pain
Status: UNKNOWN
Conditions: Fibromyalgia|Myofascial Pain Syndrome|MSK: Chronic Pain Syndromes (E.G. Fibromyalgia)|Central Sensitization
Interventions: DEVICE: shock-waves
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug Drug Interaction Study Between PF-06826647 And Oral Contraceptive Steroids In Healthy Female Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06826647|DRUG: Oral Contraceptive (OC)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of Low-intensity Shockwave Therapy for Peyronie's Disease
Status: COMPLETED
Conditions: Peyronie Disease|Penile Diseases
Interventions: DEVICE: Low intensity choc waves therapy (active applicator)|DEVICE: Sham (sham applicator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of a "Step-Up" Versus a "Step-Down" Treatment Strategy for Patients With New Onset Dyspepsia in General Practice (The DIAMOND-Study)
Status: COMPLETED
Conditions: Dyspepsia|Gastrointestinal Diseases
Interventions: DRUG: algeldrate/magnesium oxide|DRUG: ranitidine|DRUG: pantoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irinotecan and Cisplatin for High Grade Neuroendocrine Carcinoma of the Gastrointestinal Tract
Status: COMPLETED
Conditions: Gastrointestinal Cancer|Carcinoma, Neuroendocrine
Interventions: DRUG: Cisplatin|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intestinal Dysbiosis and BBB Integrity in Autism
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: OTHER: Analysis of intestinal microbiota in autism spectrum desorder|OTHER: Analysis of neuroinflammation markers in autism spectrum desorder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cyclophosphamide, VELCADE, DOXIL, and Dexamethasone, (CVDD) in Newly Diagnosed Patients With Multiple Myeloma (MM)
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Cyclophosphamide|DRUG: Bortezomib; Pegylated Liposomal Doxorubicin; Dexamethasone (VDD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Accuracy and Validity of the "Chang Gung" Ventricular Systolic Dysfunction Screening Software
Status: COMPLETED
Conditions: Left Ventricular Systolic Dysfunction
Interventions: DEVICE: "Chang Gung" Ventricular Systolic Dysfunction Screening Software
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Blood-aqueous Barrier Changes After the Use of Timolol and Prostaglandin Analogues Fixed Combination in Pseudophakic Patients With POAG
Status: COMPLETED
Conditions: Uveitis, Anterior|Cystoid Macular Edema
Interventions: DRUG: travoprost and timolol maleate fixed combination|DRUG: latanoprost and maleate timolol fixed combination|DRUG: bimatoprost and timolol maleate fixed combination|DRUG: dextran and hypromellose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Therapy With an Oxytocin Adjunct for Major Depression
Status: COMPLETED
Conditions: Depressive Disorder
Interventions: DRUG: Oxytocin nasal spray or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Renal Protective Effect of ACEI and ARB in Primary Hyperoxaluria
Status: WITHDRAWN
Conditions: Hyperoxaluria
Interventions: DRUG: ACEI / Angiotensin converting enzyme inhibitor|DRUG: ARB /Angiotensin Receptor Blocker|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Nasal Carbon Dioxide in the Treatment of Moderate to Severe Migraine
Status: TERMINATED
Conditions: Migraine
Interventions: DRUG: Nasal Carbon Dioxide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Day and Night Closed-loop With Faster-acting Insulin Aspart With Insulin Aspart
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DEVICE: FIASP + closed loop device|DEVICE: Insulin aspart (standard of care insulin) + closed loop device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Median Nerve Hydro-dissection Using Single Injection of Hyalase as a Novel Treatment of Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome|Pain, Chronic
Interventions: DRUG: Hylase|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Electronic Cigarette (ECIG) Liquid Vehicles on ECIG Acute Effects
Status: COMPLETED
Conditions: Nicotine Exposure|Nicotine Withdrawal Suppression
Interventions: OTHER: ECIG liquid vehicles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Multicenter, Post Marketing Clinical Follow up (PMCF) Investigation to Evaluate the Performance and Safety of a Soft Silicone Foam Dressing and to Evaluate the Performance of Standard Care in Exuding Venous Leg Ulcers
Status: COMPLETED
Conditions: Venous Leg Ulcer (VLU)
Interventions: DEVICE: Mepilex XT|OTHER: standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Etanercept in Subjects With Rheumatoid Arthritis Who Have Had an Inadequate Response to Adalimumab or Infliximab Plus Methotrexate
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Etanercept|DRUG: Etanercept|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Primary Chemoradiation VS. Neoadjuvant Chemotherapy Followed By Surgery As Treatment Strategy For LAVC
Status: RECRUITING
Conditions: Locally Advanced Vulvar Carcinoma|Squamous Cell Carcinoma of the Vulva
Interventions: DRUG: Paclitaxel and Carboplatin|COMBINATION_PRODUCT: Chemoradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanical Insufflator/Exsufflator Technique in Children With Neuromuscular Disease
Status: RECRUITING
Conditions: Neuromuscular Diseases in Children
Interventions: DEVICE: Mechanical insufflation/exsufflation conventional|DEVICE: Mechanical insufflation/exsufflation modified
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial of a Novel Fibrinolytic (Alfimeprase) to Clear Thrombosed Vascular Access Devices
Status: COMPLETED
Conditions: Catheters, Indwelling
Interventions: DRUG: Alfimeprase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Olmesartan on Angiotensin(1-7) Levels and Vascular Functions in Diabetes and Hypertension
Status: COMPLETED
Conditions: Angiotensin/Renin/Aldosterone Hypertension|Hypertension|Diabetes Mellitus, Type 2
Interventions: DRUG: Olmesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decreasing the Incidence of Post-Operative Nausea and Vomiting (PONV) in Bariatric Patients
Status: COMPLETED
Conditions: Nausea|Vomiting
Interventions: DRUG: Aprepitant|DRUG: Aprepitant placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study on the Effect of Two Ways of Cycloplegia on Biological Parameters of Ciliary Muscle
Status: RECRUITING
Conditions: Accomodation|Refractive Errors|Myopia|Cycloplegia
Interventions: DRUG: 1% atropine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Physiologic Change of Posterior Ocular Segment During Pregnancy
Status: NOT_YET_RECRUITING
Conditions: Retinal Vascular
Interventions: DEVICE: Optical coherence tomography and optical coherence tomography angiography (Optovue®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety, Pharmacokinetics, and Preliminary Efficacy of AMX-500 in Metastatic Castration Resistant Prostate Cancer (mCRPC)
Status: RECRUITING
Conditions: Hormone-refractory Prostate Cancer
Interventions: DRUG: AMX-500 (SAR446329)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Circulating and Tissue-specific Lipids on Vascular Function and Insulin Sensitivity in Chronic Night Shift Workers
Status: RECRUITING
Conditions: Circadian Rhythm Sleep Disorder of Shift Work Type|Metabolic Disease|Insulin Sensitivity|Blood Pressure
Interventions: BEHAVIORAL: Time-restricted eating|BEHAVIORAL: Control eating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study to Evaluate Safety and Efficacy of Cetuximab in Combination With XELOX for 12 Weeks Followed by Maintenance Treatment With Cetuximab Plus Capecitabine as First-line Treatment in Elderly Patients With Metastatic Colorectal Cancer.
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: cetuximab 5mg/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treating Dry Eyes and Corneal Ulcers With Fingerprick Autologous Blood
Status: UNKNOWN
Conditions: Dry Eyes|Sjogren's Disease With Dry Eyes|Persistent Corneal Epithelial Defects|Chronic Corneal Ulcers
Interventions: OTHER: Your own ( autologous) finger prick of blood produced with a diabetic lancet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sevoflurane in Chronic Obstructive Pulmonary Disease Exacerbation
Status: TERMINATED
Conditions: COPD Exacerbation|Invasive Mechanical Ventilation
Interventions: DRUG: Sevoflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Magnesium Alloy Screw as a Novel Bioabsorbable Material in Patients Due to Hand Fractures
Status: COMPLETED
Conditions: Hand Fractures
Interventions: DEVICE: K-MET™ Bioresorbable Bone screw
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Analysis of the Central Retina in ERF
Status: UNKNOWN
Conditions: Epiretinal Membrane|Macular Pucker
Interventions: PROCEDURE: Intraoperative ERM and ILM staining with their assessment and removal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Intervention for Persons With Amnestic Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: rehabilitation & remediation approach|BEHAVIORAL: remediation approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Kidney Damage In Patients With Severe Fall In eGFR
Status: TERMINATED
Conditions: Coronary Artery Stenosis
Interventions: DRUG: Iopamidol 370|DRUG: Iodixanol 320
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: BAYQ3939, 1000 mg Tablet in Transrectal Needle Biopsies of the Prostate (TRNBP) - Infection Prophylaxis
Status: COMPLETED
Conditions: Bacterial Infections
Interventions: DRUG: Ciprofloxacin single dose|DRUG: Ciprofloxacin triple dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Cryoanalgesia to Treat Phantom Limb Pain Following Above-Knee Amputation
Status: RECRUITING
Conditions: Amputation, Surgical|Amputation, Traumatic|Phantom Limb Pain|Phantom Pain Following Amputation of Lower Limb
Interventions: DEVICE: ACTIVE cryoneurolysis|DEVICE: SHAM cryoneurolysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Confirmatory Study of KUC-7483 in Patients With Overactive Bladder
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: KUC-7483|DRUG: Placebo|DRUG: Tolterodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of EverVita Pro, a Protein Rich Ingredient, on Satiety Measures, Subsequent Energy Intake, and Gastrointestinal Symptoms: A Randomized, Controlled, Cross-over Study in Healthy Subjects
Status: COMPLETED
Conditions: Satiety of High Fiber High Protein Bread
Interventions: OTHER: EverVita Pro|OTHER: Control bread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Correlative Study on Cancer Patients and Healthcare Professionals Exposed to Infection by Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-Cov-2), COVID-19 Causative Agent.
Status: UNKNOWN
Conditions: COVID-19|SARS-CoV-2
Interventions: OTHER: serological test|OTHER: Rapid molecular test|GENETIC: Next generation Sequencing (NGS) analysis|OTHER: serum chemistry analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intravenous Ferric Carboxymaltose vs IV Iron Sucrose or IV Iron Dextran in Treating Iron Deficiency Anemia in Women
Status: COMPLETED
Conditions: Iron Deficiency Anemia
Interventions: DRUG: Ferric Carboxymaltose (FCM)|DRUG: Iron Sucrose / Iron Dextran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of the Endologix Fenestrated Stent Graft System
Status: COMPLETED
Conditions: Juxtarenal Aortic Aneurysm|Pararenal Aortic Aneurysm
Interventions: DEVICE: Ventana Fenestrated Stent Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effectiveness and Safety of 5 Percent Minoxidil Foam in the Treatment of Male Pattern Hair Loss
Status: COMPLETED
Conditions: Androgenetic Alopecia
Interventions: DRUG: minoxidil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: High Dose Chemotherapy and Stem Cell Transplant for Non-Hodgkin's Lymphoma or Central Nervous System (CNS) Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma|CNS Lymphoma
Interventions: PROCEDURE: Autologous stem cell transplant|DRUG: High-dose chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine in Newly-Diagnosed Diffuse Intrinsic Pontine Glioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Diffuse Intrinsic Pontine Glioma
Interventions: DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Can Needle Size Improve Cancer Detection Rate of Transperineal MRI Target Prostate Biopsy Without Affecting Side Effects?
Status: RECRUITING
Conditions: Prostate Cancer Diagnosis
Interventions: DEVICE: different needle size for prostate biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Local Application of Boron on Diabetic Foot Ulcers
Status: UNKNOWN
Conditions: Diabetic Foot Ulcer
Interventions: DRUG: boron gel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Precision Medicine in Patients With Unresectable CholAngiocarcinoma: RadioEmbolization and Combined Biological Therapy
Status: RECRUITING
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: RADIATION: radioembolization with Y-90|DRUG: Durvalumab|DRUG: Cisplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Tolerance, Pharmacokinetics and Efficacy of TQ-A3334 Tablets
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: TQ-A3334|DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Robot-assisted Total Knee Arthroplasty With Automatic Balancing
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: Conventional Total Knee Arthroplasty|PROCEDURE: Robot-Assisted Total Knee Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dopamine, Reward Learning and Sex Hormones
Status: RECRUITING
Conditions: Hormonal Changes|Menstrual Cycle
Interventions: DRUG: Levodopa administration|DRUG: Placebo administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Carboplatin Plus Vincristine in Treating Children and Adolescents With Low Grade Glioma
Status: UNKNOWN
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: carboplatin|DRUG: vincristine sulfate|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Preoperative Accelerated Partial Breast Irradiation (APBI) for Women With Stage I and Select IIA Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: Phase II - Preoperative Radiation followed by Lumpectomy.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION