pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase I Study to Evaluate Safety, Tolerability, and Pharmacokinetics of HS-10360 in Healthy Subjects.
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: HS-10360|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pasireotide in Combination With RAD001 in Patients With Advanced Neuroendocrine Tumors
Status: COMPLETED
Conditions: Neuroendocrine Tumor|Carcinoid Tumor|Pancreatic Neuroendocrine Tumor
Interventions: DRUG: SOM230|DRUG: RAD001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of N-acetylcysteine on Alcohol and Cocaine Use Disorders: A Double-Blind Randomized Controlled Trial.
Status: UNKNOWN
Conditions: Cocaine Addiction|Alcohol Addiction
Interventions: DRUG: Alcohol N-acetylcysteine|DRUG: Alcohol Placebo|DRUG: Cocaine N-acetylcysteine|DRUG: Cocaine Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Perceived Control on Operational Strain: a Study of COVID-19 Pandemic Caregivers and Military Personnel on Operational Missions
Status: UNKNOWN
Conditions: Covid19|SARS-CoV Infection|Burnout, Caregiver|Burnout, Professional
Interventions: BEHAVIORAL: Assessment of work-related stress|BIOLOGICAL: Saliva sample collection|DEVICE: Cardiac and electrodermal recordings|BEHAVIORAL: Assessment of behavioral response to emotional stimulation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Stratified TreAtment to Reduce Risk in COPD
Status: COMPLETED
Conditions: COPD Exacerbation
Interventions: DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Perennial and Preseasonal Subcutaneous Immunotherapy
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: grass (80%) and rye (20%) pollens allergoids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Infectivity of Norovirus in Shellfish Treated With High Hydrostatic Pressure Processing-Human Challenge Study
Status: COMPLETED
Conditions: Healthy
Interventions: PROCEDURE: High Hydrostatic Pressure Processing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: T Cell Effector and Regulatory Mechanisms in Asthma
Status: COMPLETED
Conditions: Asthma|Allergies
Interventions: BIOLOGICAL: Bronchoscopy, Segmental Allergen Challenge and Broncheoalveolar Lavage|PROCEDURE: PET-CT imaging(13NN perfusion/ventilation, 18FDG inflammation, and CT imaging)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Pharmacokinetic Characteristics of HD203 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: HD203
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Body Position and Ultrasound Examination of the Gastric Antrum
Status: COMPLETED
Conditions: Pulmonary Aspiration of Gastric Contents
Interventions: OTHER: Qualitative and quantitative assessment of gastric content volume with bed elevation|OTHER: Qualitative and quantitative assessment of gastric content volume without bed elevation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparative Study Between Intravenous Granisetron and Ondansetron on Their Effect on Hemodynamics and Shivering After Spinal Anesthesia in Elective Cesarean Delivery
Status: RECRUITING
Conditions: Hemodynamic Instability and Shivering
Interventions: DRUG: ondansetron|DRUG: granisetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Lonafarnib in Combination With Paclitaxel and Carboplatin in Patients With Non-Small Cell Lung Cancer (Study P01901)(TERMINATED)
Status: TERMINATED
Conditions: Carcinoma, Non-small-cell Lung|Metastases, Neoplasm
Interventions: DRUG: Lonafarnib (SARASAR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: PhaseI/II Investigator-Initiated Trial to Investigate Safety and Efficacy of Ripasudil in Patients With Retinopathy of Prematurity
Status: COMPLETED
Conditions: Retinopathy of Prematurity
Interventions: DRUG: Ripasudil ophthalmic solution 0.4%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Probiotics On Bowel Function Restoration After Ileostomy Closure In Patients With Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: DIETARY_SUPPLEMENT: CJLP243|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PF-07265028 As Single Agent And In Combination With Sasanlimab in Advanced or Metastatic Solid Tumors
Status: TERMINATED
Conditions: Advanced Solid Tumors|Gastric Cancer|Gastroesophageal Junction Cancer|Urothelial Cancer|Non Small Cell Lung Cancer|Head and Neck Squamous Cell Carcinomas
Interventions: DRUG: PF-07265028|BIOLOGICAL: Sasanlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TAS-120 in Patients With Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Breast Cancer|FGFR 1 High Amplification|FGFR2 Amplification
Interventions: DRUG: Futibatinib|DRUG: Futibatinib plus Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Guo's Visceral Arteries Reconstruction: First in Man Study
Status: COMPLETED
Conditions: Thoracoabdominal Aortic Aneurysm|Pararenal Aortic Aneurysm
Interventions: DEVICE: Thoracoabdominal aortic stent system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Training and Social Interaction Effects on Cognitive Performance of Older Adults
Status: COMPLETED
Conditions: Cognitive Decline
Interventions: OTHER: Social interaction combined with cognitive training based on mnemonic strategies.|OTHER: Social interaction group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pilot Study Of Unrelated UCB Transplant for Non-Malignant Hematologic Conditions
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases
Interventions: BIOLOGICAL: anti-thymocyte globulin|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: melphalan|DRUG: methylprednisolone|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: umbilical cord blood transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Education of Medical Team on Duration of Fasting Before Elective Medical Interventions Performed Under General Anesthesia in Children
Status: WITHDRAWN
Conditions: Duration of Preoperative Fasting
Interventions: OTHER: education
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Intravenous Dexamethasone Effectiveness in Post Caesarean Section Analgesia
Status: COMPLETED
Conditions: Cesarean Section|Dexamethasone|Postoperative Pain|Spinal Anesthesia
Interventions: DRUG: Dexamethasone 4mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Biodistribution of Technetium Tc 99m EC20 in Normal Volunteers and Ovarian Cancer Patients
Status: COMPLETED
Conditions: Ovarian Cancer|Healthy Volunteers
Interventions: DRUG: Tc 99m EC20
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Platform Switching on Single Implants in the Esthetic Zone, Following Flapless Surgery and Early-Loading Protocols
Status: COMPLETED
Conditions: the Impact of Platform-switching
Interventions: OTHER: platform-switched implants|OTHER: platform-matched implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Increasing Uptake of Evidence-Based Screening Services Through CHW-led Multi-modality Intervention
Status: COMPLETED
Conditions: Human Papillomavirus|Human Immunodeficiency Virus|Hepatitis C|ColoRectal Cancer
Interventions: DEVICE: OraQuick Swab|DEVICE: Fecal Immunochemical Test|DEVICE: OraQuick Fingerstick|OTHER: Standard Screening Tests|DEVICE: HPV Self-Sampling Test|OTHER: Home Based Screening Tests
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Cisplatin With or Without Pemetrexed Disodium in Treating Patients With Malignant Mesothelioma of the Pleura That Cannot be Removed by Surgery
Status: COMPLETED
Conditions: Malignant Mesothelioma
Interventions: DRUG: cisplatin|DRUG: pemetrexed disodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of Tislelizumab Combined With Radiotherapy as the Second-line Treatment of Advanced Biliary Malignant Tumors
Status: UNKNOWN
Conditions: Cholangiocarcinoma
Interventions: COMBINATION_PRODUCT: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a Monovalent Inactivated Influenza H3N2 Variant (H3N2v) Vaccine in Pediatric Populations
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza Virus Vaccine, Monovalent A/H3N2v A/Minnesota/11/2010 NYMC X-203
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: PREVENTION
Clinical trial: Duvelisib Exposure to Enhance Immune Profiles of T Cells in Patients With Recurrent or Refractory Diffuse Large B-Cell Lymphoma, DEEP T CELLS Study
Status: RECRUITING
Conditions: Recurrent Diffuse Large B-Cell Lymphoma|Refractory Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Duvelisib|BIOLOGICAL: Tisagenlecleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Betahistine on Body Weight in Obese Female Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: betahistine dihydrochloride|DRUG: betahistine dihydrochloride|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Intermittent Doses of CERC-301 in MDD
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: CERC-301|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of CCT301 CAR-T in Adult Subjects With Recurrent or Refractory Stage IV Renal Cell Carcinoma
Status: UNKNOWN
Conditions: Renal Cell Carcinoma
Interventions: BIOLOGICAL: CCT301-38|BIOLOGICAL: CCT301-59
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Acute Periprosthetic Joint Infection Comparing Single and Planned Double-Debridement Antibiotics and Implant Retention Followed by Chronic Antibiotic Suppression
Status: ENROLLING_BY_INVITATION
Conditions: Periprosthetic Joint Infection
Interventions: PROCEDURE: Single Debridement, Antibiotics and Implant Retention|PROCEDURE: Planned Double Debridement, Antibiotics and Implant Retention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Versus Late Drain Removal After Pancreatectomy: A Randomized Prospective Trial
Status: UNKNOWN
Conditions: Pancreatectomy|Post Procedural Discharge
Interventions: OTHER: Early drain removal|OTHER: Late drain removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biobehavioral Intervention in Gynecologic Oncology Patients
Status: COMPLETED
Conditions: Neoplasms|Ovarian Neoplasms|Uterine Neoplasms|Vulva
Interventions: BEHAVIORAL: BBI intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ultrasound Imaging of Kidney Stones and Lithotripsy
Status: NOT_YET_RECRUITING
Conditions: Kidney Stones|Nephrolithiasis|Urolithiasis|Ureter Stones
Interventions: DEVICE: Verasonics Data Acquisition System (VDAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Peripheral Neuropathy in Colorectal Cancer Patients Under Adjuvant Chemotherapy With FOLFOX, FLOX or XELOX Regime
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DEVICE: VibrosSense Meter®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trastuzumab or Observation After Combination Chemotherapy and Trastuzumab in Treating Patients Undergoing Surgery for Stage II or Stage III Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: BIOLOGICAL: trastuzumab|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: fluorouracil|DRUG: paclitaxel|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Taperloc Complete Microplasty vs Taperloc Complete Standard: Randomized Controlled Study on Bone Mineral Density
Status: COMPLETED
Conditions: Osteoarthritis|Avascular Necrosis|Traumatic Arthritis|Rheumatoid Arthritis|Legg-Perthes Disease
Interventions: DEVICE: Taperloc Complete Microplasty|DEVICE: Taperloc Complete Standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: To Calculate the Pharmacokinetics (Concentration of Compound in and Rate of Excretion From the Blood) Following a Very Low Dose of Compound Which Will Not Have Any Pharmacological Activity
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-05186462|DRUG: PF-05186462|DRUG: PF-05089771|DRUG: PF-05089771|DRUG: PF-05150122|DRUG: PF-05150122|DRUG: PF-05241328|DRUG: PF-05241328
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Oxidant-antioxidant Activity, Free Radicle Activity, Immune Response and Biomarkers in Extracorporeal Membrane Oxygenation (ECMO) Patients
Status: UNKNOWN
Conditions: Cardiogenic Shock|Acute Myocardial Infarction|Myocarditis|Cardiomyopathy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Transdiagnostic Intervention for Health-related Habits (LEV)
Status: COMPLETED
Conditions: Intervention|Life Style|Health-Related Behavior|Feasibility|Quality of Life|Disabilities Physical|Disability Physical|Mental Health Wellness
Interventions: BEHAVIORAL: Lev
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Adapalene Topical Gel in Patients With Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Adapalene|DRUG: Differin®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: Cassava Intervention Project
Status: COMPLETED
Conditions: Neurotoxicity Syndrome, Cassava|Neurotoxicity Syndrome, Cyanate|Neurotoxicity Syndrome, Cyanide|Neurotoxicity Syndrome, Thiocyanate
Interventions: OTHER: Non Inferiority WTM Interventional Trial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Reversal of an Unfavorable Effect of Hydrochlorothiazide Compared to Angiotensin Converting Enzyme Inhibitor on Serum Uric Acid and Oxypurines Levels by Estrogen-progestin Therapy in Hypertensive Postmenopausal Women.
Status: COMPLETED
Conditions: Hypertension|Hyperuricemia|Menopause
Interventions: DRUG: Perindopril|DRUG: Hydrochlorothiazide|DRUG: Estracomb TTS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Pilates in Muscle Strength of the Pelvic Floor as Treatment of Post Prostatectomy Urinary Incontinence
Status: COMPLETED
Conditions: Prostate Cancer|Urinary Incontinence
Interventions: OTHER: Pilates|OTHER: PFMT and AES|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CryoBalloon Ablation for Treatment of Duodenal Adenomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Duodenal Adenomas|Familial Adenomatous Polyposis
Interventions: DEVICE: CryoBalloon ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of User and Expert Driven Internet-based Lifestyle Interventions on Hypertension Control
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: Control Group|BEHAVIORAL: Expert-Driven Group|BEHAVIORAL: User-driven group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Immune Response of MUC1 (Mucin1) Peptide Vaccine for Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: BIOLOGICAL: Vaccine + PolyICLC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improvement of Insulin Resistance With Traditional Chinese Treatment in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Coptis Chinensis, Astragalus mambranesceus, Lonicera Japonica (Traditional Chinese Treatment)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Rivaroxaban After Bariatric Surgery
Status: COMPLETED
Conditions: Bariatric Surgery|Morbid Obesity
Interventions: DRUG: rivaroxaban 20 mg once daily 8 days
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label, Multicenter, Phase 1/2 Study of Poly(ADP-Ribose) Polymerase (PARP) Inhibitor E7449 as Single Agent in Subjects With Advanced Solid Tumors or With B-cell Malignancies and in Combination With Temozolomide (TMZ) or With Carboplatin and Paclitaxel in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Malignant Solid Tumour|Ovarian Cancer|Triple Negative Breast Cancer|Advanced Melanoma|B-cell Malignancy, Low-grade
Interventions: DRUG: E7449 alone|DRUG: E7449 plus TMZ|DRUG: E7449 plus carboplatin and paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab, Vaccine Therapy, and GM-CSF in Treating Patients With Non-Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: BIOLOGICAL: autologous immunoglobulin idiotype-KLH conjugate vaccine|BIOLOGICAL: rituximab|BIOLOGICAL: sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Monoclonal Antibondy (GS) 5745, an Matix Metalloproteinase 9 (MMP9) Mab Inhibitor, in Combination With Bevacizumab in Patients With Recurrent Glioblastoma
Status: UNKNOWN
Conditions: Glioblastoma
Interventions: DRUG: Monoclonal antibody|DRUG: Bevacizumab|BIOLOGICAL: Blood sample|DEVICE: Dynamic Contrast Enhanced magnetic resonance imaging (DCE-MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maximal Use Systemic Exposure Study of Levulan Kerastick (MUSE 2)
Status: COMPLETED
Conditions: Keratosis, Actinic
Interventions: DRUG: Aminolevulinic Acid (ALA)|DEVICE: BLU-U
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neoadjuvant Cisplatin/Docetaxel (CDDP/TXT) and Chemoradiation for Head and Neck Cancer
Status: UNKNOWN
Conditions: Head and Neck Neoplasms
Interventions: DRUG: Docetaxel/cisplatin|RADIATION: Radiotherapy|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nursing Interventions on Prevention Medical Device Related Pressure Injury (MDRPI)
Status: NOT_YET_RECRUITING
Conditions: Medical Device Site Erosion
Interventions: PROCEDURE: The skin care Bundle|PROCEDURE: Routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Inhaling Hypertonic Saline in Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: hypertonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irinotecan Liposome for Resectable Pancreatic Cancer With or Without Addebelizumab
Status: NOT_YET_RECRUITING
Conditions: Neoadjuvant Chemotherapy|Resectable Pancreatic Cancer
Interventions: DRUG: irinotecan liposome + oxaliplatin + 5-FU / LV|DRUG: Adebellizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II-IV Anaplastic Large Cell Lymphoma
Status: COMPLETED
Conditions: Anaplastic Large Cell Lymphoma, ALK-Positive|Ann Arbor Stage II Noncutaneous Childhood Anaplastic Large Cell Lymphoma|Ann Arbor Stage III Noncutaneous Childhood Anaplastic Large Cell Lymphoma|Ann Arbor Stage IV Noncutaneous Childhood Anaplastic Large Cell Lymphoma
Interventions: DRUG: Brentuximab Vedotin|DRUG: Crizotinib|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Dexamethasone|DRUG: Doxorubicin Hydrochloride|DRUG: Etoposide|DRUG: Ifosfamide|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Effectiveness of Real-time, Remote Continuous Glucose Monitoring in Adolescents With Poorly Controlled Type 1 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1|Noncompliance, Patient
Interventions: OTHER: Continuous Glucose Monitoring|OTHER: Secure texting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Non-Steroidal Anti-Inflammatory Drug (NSAID) Response and Central Sensitization of Pain in Women With Dysmenorrhea
Status: RECRUITING
Conditions: Dysmenorrhea|Menstrual Pain|Non-steroidal Anti-inflammatory Drug
Interventions: DRUG: Sodium Naproxen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Trilaciclib, a CDK4/6 Inhibitor, in Patients With Early-Stage Triple Negative Breast Cancer
Status: COMPLETED
Conditions: Triple Negative Breast Cancer|Breast Cancer
Interventions: DRUG: Trilaciclib|DRUG: Cylophosphamide|DRUG: Doxorubicin|DRUG: Paclitaxel|DRUG: Carboplatin (Investigator discretion)|BIOLOGICAL: Pembrolizumab (Investigator discretion)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Applied Relaxation (AR) Technique Versus Its Modified Version for Treating Menopausal Symptoms
Status: COMPLETED
Conditions: Hot Flashes|Night Sweats|Sleep Disturbances
Interventions: BEHAVIORAL: Modified Relaxation (MR)|BEHAVIORAL: Applied Relaxation (AR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Insulin Therapy in Chronic Obstructive Pulmonary Disease (COPD) Exacerbations
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease|Hyperglycemia
Interventions: PROCEDURE: Blood glucose monitoring|DRUG: Insulin Glulisine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Lidocaine Patch for Shoulder Pain in Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Gallbladder Diseases
Interventions: DRUG: Lidocaine patch and hypafix|DRUG: hypafix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acthar for Treatment of Proteinuria in Diabetic Nephropathy Patients
Status: COMPLETED
Conditions: Diabetic Nephropathy
Interventions: DRUG: Repository Corticotropin Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of PF-04965842 Effect on Dabigatran Pharmacokinetics in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-04965842|DRUG: Dabigatran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Pembrolizumab With Trastuzumab and Chemotherapy in Advanced HER2 Positive Esophagogastric (EG) Cancer
Status: COMPLETED
Conditions: Esophageal Cancer|Gastric Cancer
Interventions: DRUG: pembrolizumab|DRUG: trastuzumab|DRUG: capecitabine|DRUG: cisplatin|DRUG: Oxaliplatin|DRUG: 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ZK283197 for Treatment of Vasomotor Symptoms
Status: COMPLETED
Conditions: Vasomotor System
Interventions: DRUG: BAY 86-5310 (ZK 283197)|DRUG: Placebo|DRUG: 17ß-estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy Of BioMin F, Colgate Sensitive Pro-Relief And Sensodyne Rapid Action Dentifrices In DH
Status: COMPLETED
Conditions: Dentin Hypersensitivity
Interventions: DRUG: Fluoro-Calcium-Phospho-Silicate based dentifrices|DRUG: 8% Arginine based dentifrices|DRUG: 8% Strontium Acetate|DRUG: Sodium Fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GDM Patients and Serum Amyloid A and Interleukin-1 (IL-1) Receptor Antagonist
Status: COMPLETED
Conditions: Gestational Diabetes
Interventions: DIAGNOSTIC_TEST: Serum amyloid A values|DIAGNOSTIC_TEST: Interleukin-1 (IL-1) receptor antagonist values (A-SAA and IL-1Ra)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess Pregnancy Outcomes in Women Exposed to Diroximel Fumarate
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: Diroximel Fumarate|BIOLOGICAL: Alemtuzumab|DRUG: Fingolimod|DRUG: Glatiramer acetate|BIOLOGICAL: Interferon beta|BIOLOGICAL: Natalizumab|BIOLOGICAL: Ocrelizumab|BIOLOGICAL: Ofatumumab|DRUG: Ozanimod|BIOLOGICAL: Peginterferon beta-1a|DRUG: Ponesimod|DRUG: Siponimod
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of the 48-Week Virologic and Immunologic Response to Lopinavir/Ritonavir (Kaletra) in HIV Positive Adult Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Kaletra
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Compare the Safety and Pharmacokinetics of PT105 With PT105R in Healthy Postmenopausal Female Volunteers
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DRUG: leuprorelin acetate 3.75mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Microbial Invasion During Parenteral Nutrition in Surgical Infants Receiving Glutamine
Status: COMPLETED
Conditions: Surgical Infants Requiring Total Parenteral Nutrition
Interventions: DIETARY_SUPPLEMENT: Isonitrogenous Vaminolact|DRUG: Dipeptiven (L-glutamine- Lalanine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Synbiotic on Immune Response, Gut Permeability and Microbiota in Patient With Connective Tissue Disease
Status: COMPLETED
Conditions: Connective Tissue Diseases
Interventions: DIETARY_SUPPLEMENT: Synbiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Homeopathic Medicines in Treatment of Allergic Rhinitis and/or Induced Bronchial Asthma
Status: COMPLETED
Conditions: Rhinitis; Allergic, With Asthma
Interventions: OTHER: Individualized homeopathic medicines|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Echocardiographic Study of the Haemodynamic Effects of Remifentanil With and Without Glycopyrrolate in Healthy Children
Status: COMPLETED
Conditions: Urological Surgery
Interventions: DRUG: Administration of remifentanil and glycopyrrolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Obex, a Nutritional Supplement, in Overweight and Obese Spanish Women
Status: COMPLETED
Conditions: Obesity|Overweight
Interventions: DIETARY_SUPPLEMENT: Obex|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CapTemY90 for Grade 2 NET Liver Metastases
Status: RECRUITING
Conditions: Neuroendocrine Tumor Grade 2|Neuroendocrine Tumors
Interventions: DRUG: Capecitabine Oral Product|DRUG: Temozolomide Oral Product|COMBINATION_PRODUCT: transarterial radioembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Tranexamic Acid on Transfusion Rates in Intertrochanteric Hip Fractures
Status: WITHDRAWN
Conditions: Hip Fracture|Blood Loss
Interventions: DRUG: Tranexamic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Local Anesthetic Injection Depth on Procedural Pain and Discomfort During Fluoroscopically Guided Lumbar Transforaminal Epidural Injections
Status: COMPLETED
Conditions: Lumbar Radiculopathy Due to Spinal Nerve Compression
Interventions: PROCEDURE: 1ml of local anesthetics (1% Lidocaine) were injected into the subcutaneous layer.|PROCEDURE: 1ml of a local anesthetics (1% idocaine) are first injected into the subcutaneous layer, followed by 3~4ml of local anesthetics to the muscle layer along the expected needle pathway.|DRUG: 1% Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomised Controlled Trial (RCT) of 6 Versus 3 Steps for Hand Hygiene
Status: COMPLETED
Conditions: Hand Hygiene
Interventions: OTHER: 6 step technique|OTHER: 3 step technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Contralateral Comparison of Three Excimer Laser Systems in Performing LASIK
Status: COMPLETED
Conditions: Myopia|Astigmatism
Interventions: DEVICE: Excimer Laser|DEVICE: AMO/VISX CustomVue™|DEVICE: LADARVision 4000 excimer laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cemiplimab With or Without Fianlimab to Treat Older Patients With Localized or Locally Advanced MSI-H Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: Cemiplimab|DRUG: Fianlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Now Matters Now: An Online Suicide Prevention Program
Status: COMPLETED
Conditions: Suicide|Suicide, Attempted|Suicidal Ideation
Interventions: BEHAVIORAL: DBT Online Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Effect of the Drug Gabapentin on Postoperative Pain and Incidence of Postoperative Nausea and Vomiting
Status: COMPLETED
Conditions: Obesity, Morbid|Postoperative Pain|Postoperative Nausea and Vomiting
Interventions: DRUG: Gabapentin|DRUG: Placebo|DRUG: Gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Warm Fluid Distension Media in Relieving Pain in Outpatient Hysteroscopy
Status: COMPLETED
Conditions: Office Hysteroscopy
Interventions: PROCEDURE: warming saline media|PROCEDURE: room temperature saline media
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Pumpkin Seed Oil or Pumpkin Seeds on Blood Pressure and Menopausal Symptoms in Postmenopausal Women
Status: COMPLETED
Conditions: Hypertension|Dyslipidemia
Interventions: DIETARY_SUPPLEMENT: Pumpkin seed oil|DIETARY_SUPPLEMENT: Pumpkin seeds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Sleep Lab Trial to Investigate the Efficacy and Safety of Transdermal Rotigotine in Subjects With Idiopathic Restless Legs Syndrome
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DRUG: Rotigotine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Glofitamab as a Single Agent vs. Investigator's Choice in Participants With Relapsed/Refractory Mantle Cell Lymphoma
Status: RECRUITING
Conditions: Lymphoma
Interventions: DRUG: Obinutuzumab|DRUG: Glofitamab|DRUG: Rituximab|DRUG: Bendamustine|DRUG: Lenalidomide|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Mesenchymal Stromal Cells in Elderly Patients With Hip Fracture
Status: WITHDRAWN
Conditions: Femoral Neck Fracture
Interventions: DRUG: XCEL-MT-OSTEO-BETA|PROCEDURE: Surgical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Three Doses of Vildagliptin in Drug Naive Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: APOL1 Genetic Testing Program for Living Donors, Part 2
Status: ENROLLING_BY_INVITATION
Conditions: Chronic Kidney Diseases|Genetic Predisposition
Interventions: BEHAVIORAL: APOL1 Counseling Training Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Liver Resection Modeling
Status: UNKNOWN
Conditions: Benign Liver Tumor|Malignant Tumor Liver|Cirrhosis
Interventions: PROCEDURE: partial hepatectomy by laparotomy on healthy or pathologic parenchyma.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Screening in Primary Care of Advanced Liver Fibrosis in NAFLD and/or Alcoholic Patients (IMPROVE Study)
Status: COMPLETED
Conditions: NAFLD|Alcohol-Related Disorder|Liver Fibrosis
Interventions: DIAGNOSTIC_TEST: e-LIFT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Helicobacter Pylori Empiric Treatment in Ulcer Bleeding
Status: UNKNOWN
Conditions: Peptic Ulcer Hemorrhage
Interventions: OTHER: Empirical Hp eradication|OTHER: Eradication treatment guided by a positive test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Stem Cell Transplant (ASCT) for Autoimmune Diseases
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus|Systemic Sclerosis
Interventions: BIOLOGICAL: Depletion of CD3/CD19 in an autologous stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Different Massage Techniques in Women With Primary Dysmenorrhea
Status: UNKNOWN
Conditions: Primary Dysmenorrhea
Interventions: OTHER: Classic massage group|OTHER: Connective tissue masage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Tai Chi Exercise Among Elders With Sarcopenia
Status: COMPLETED
Conditions: Sarcopenia in Elderly|Tai Chi
Interventions: BEHAVIORAL: Tai-Chi|BEHAVIORAL: Comprehensive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: CD123 Redirected T Cells for AML in Pediatric Subjects
Status: RECRUITING
Conditions: Acute Myeloid Leukemia, in Relapse|Acute Myeloid Leukemia, Pediatric|Acute Myeloid Leukemia, Refractory
Interventions: BIOLOGICAL: CART123 cells; cyclophosphamide; fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Related to Head and Neck Cancer (HNC); Implementation and Evaluation of Self-care Measure Due to the Same Illness
Status: COMPLETED
Conditions: Pain|Head and Neck Cancer
Interventions: BEHAVIORAL: Education|BEHAVIORAL: Self Care|OTHER: Treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Atezolizumab and Bevacizumab in EGFR Mutant NSCLC in Patients With Progressive Disease After Receiving Osimertinib
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Atezolizumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Gemcabene in Hypercholesterolemic Patients as Monotherapy or in Combination With Atorvastatin
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Gemcabene|DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial Testing Oral Administration of Lucitanib in Patients With Fibroblast Growth Factor Receptor (FGFR)1-amplified or Non-amplified Estrogen Receptor Positive Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: lucitanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PeproStat as a Topical Agent Used to Stop Bleeding in Patients Undergoing Surgery
Status: COMPLETED
Conditions: Bleeding
Interventions: DRUG: PeproStat|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Angioplasty of Distal Lesions for Carriers of Inoperable Post-embolic HTP
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: PROCEDURE: Percutaneous angioplasty|PROCEDURE: Balloon angioplasty|PROCEDURE: Right heart catheterization|PROCEDURE: Echocardiography|OTHER: A six-minute walking test|PROCEDURE: Functional respiratory investigations|PROCEDURE: Pulmonary tomography or pulmonary angiography|OTHER: Biological parameters
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II, Randomized, Double-blind, Placebo, and Active Controlled Clinical Study to Evaluate the Safety, Tolerability, Immunogenicity, and Preliminary Efficacy of JHM03 in Subjects With Moderate to Severe Glabellar Lines
Status: RECRUITING
Conditions: Moderate to Severe Glabellar Lines
Interventions: BIOLOGICAL: JHM03|BIOLOGICAL: BOTOX®|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preventive Effect of the PRetreatment With Intravenous Nicorandil on Contrast-Induced Nephropathy in Patients With RenaL Dysfunction UndEergoing Coronary Angiography (PRINCIPLE Study)
Status: COMPLETED
Conditions: Chronic Renal Failure
Interventions: DRUG: pretreatment with intravenous nicorandil vs. placebo before coronary angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of a Novel Stretching Technique on Shoulder Range of Motion and Voluntary Contraction in Overhead Athletes With Glenohumeral Internal Rotation Deficits "GIRD"
Status: COMPLETED
Conditions: Glenohumeral Internal Rotation Deficits
Interventions: PROCEDURE: Stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Personalized Melphalan Dosing in the Setting of Autologous Transplant
Status: WITHDRAWN
Conditions: Hematopoietic Cell Transplantation Recipient|Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Melphalan Hydrochloride|DRUG: Melphalan Hydrochloride|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine to Improve Outcomes During Emergence From Retroperitoneal Laparoscopic Surgery
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: dexmedetomidine|OTHER: loading dose|OTHER: sustaining dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ginsenoside Improve Metabolic Syndrome
Status: UNKNOWN
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Ginsenoside|DIETARY_SUPPLEMENT: Dietary fiber fill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Time Course of the Antiproteinuric and Blood Pressure Lowering Effects After Initiation of Renin Inhibition With Aliskiren in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Type 2
Interventions: DRUG: Aliskiren
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy With or Without Interleukin-2 After Chemotherapy and an Autologous White Blood Cell Infusion in Treating Patients With Metastatic Melanoma
Status: TERMINATED
Conditions: Recurrent Melanoma|Stage IV Melanoma
Interventions: DRUG: cyclophosphamide|DRUG: fludarabine phosphate|BIOLOGICAL: therapeutic autologous lymphocytes|PROCEDURE: in vitro-treated peripheral blood stem cell transplantation|BIOLOGICAL: gp100 antigen|BIOLOGICAL: MART-1 antigen|BIOLOGICAL: incomplete Freund's adjuvant|BIOLOGICAL: filgrastim|BIOLOGICAL: aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT