pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Phase II Study of Balstilimab Independently or in Combination With Zalifrelimab in Advanced Cervical Cancer
Status: WITHDRAWN
Conditions: Cervical Cancer
Interventions: DRUG: Balstilimab|DRUG: Balstilimab + Zalifrelimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof-of-concept to Evaluate the Efficacy and Safety of Prednisone in Idiosyncratic Hepatotoxicity
Status: NOT_YET_RECRUITING
Conditions: Hepatotoxicity|Idiosyncratic Drug Effect|Prednisone
Interventions: DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Open Label, Prospective Study to Explore the Clinical Characteristics of Oral MNK155 and Norco 7.5mg/325 When Used for the Treatment of Moderate to Severe Post Operative Pain
Status: TERMINATED
Conditions: Post Operative Pain
Interventions: DRUG: Norco 7.5mg/325|DRUG: MNK155
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: The Effect of Using Interactive Mobile Application for the Management of Chemotherapy- Induced Nausea and Vomiting in Children
Status: COMPLETED
Conditions: Oncology|Nausea and Vomiting Chemotherapy-Induced|Pediatric Cancer|Mobile Application
Interventions: DEVICE: 5inD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lenalidomide & High Dose Dexamethasone for Untreated Multiple Myeloma Renal Failure Patients
Status: COMPLETED
Conditions: Renal Failure|Multiple Myeloma
Interventions: DRUG: Lenalidomide and Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence, Etiology and Effects on Oral Health and Life Quality of Molar Incisor Hypomineralization
Status: COMPLETED
Conditions: Molar Incisor Hypomineralization|Oral Health|Child, Only|Pediatric ALL|Dental Caries|Dental Plaque|Dental Diseases
Interventions: OTHER: survey application
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination Chemotherapy in Treating Patients Undergoing Surgery for Newly Diagnosed High-Grade Osteosarcoma
Status: COMPLETED
Conditions: Sarcoma
Interventions: DRUG: cisplatin|DRUG: doxorubicin hydrochloride|DRUG: ifosfamide|DRUG: methotrexate|PROCEDURE: adjuvant therapy|PROCEDURE: neoadjuvant therapy|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effect of Avocado on Cardiovascular Disease (CVD) Risk Factors
Status: COMPLETED
Conditions: Cardiovascular Disease|Hyperlipidemia
Interventions: OTHER: Avocado Diet|OTHER: Lower-Fat Diet|OTHER: Moderate Fat Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Clinical Study of CD20 CAR-T Cells in Patients With Relapsed and Refractory B Cell Non-Hodgkin Lymphoma
Status: UNKNOWN
Conditions: Relapsed and Refractory B Cell Lymphoma|Non-Hodgkin Lymphoma
Interventions: BIOLOGICAL: CD20 CAR-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Dabigatran Etexilate Solution in Children 1 to < 12 Years of Age
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DRUG: dabigatran etexilate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Neo-adjuvant Pembrolizumab in Vulvar Squamous Cell Carcinoma: a Clinical Proof-of-concept Study
Status: NOT_YET_RECRUITING
Conditions: Vulva Cancer|Vulva Neoplasm|Squamous Cell Cancer
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Second-generation Drug-eluting Stents in Diabetes
Status: UNKNOWN
Conditions: Coronary Artery Disease|Diabetes Mellitus
Interventions: DEVICE: Polymer-free amphilimus-eluting stents|DEVICE: Biolinx Polymer-based zotarolimus-eluting stents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Polyphenols on Absorption of Iron From Sodium Iron Chlorophyllin
Status: COMPLETED
Conditions: Iron-deficiency
Interventions: DIETARY_SUPPLEMENT: SIC|DIETARY_SUPPLEMENT: SIC + tea|DIETARY_SUPPLEMENT: FeSO4|DIETARY_SUPPLEMENT: FeSO4 + tea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TITAN (Tumoural Injection of T-VEC and Isolated Limb Perfusion)
Status: COMPLETED
Conditions: Melanoma and Sarcoma
Interventions: DRUG: Talimogene laherparepvec (T-VEC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of iMentalize and MISC-SA to Foster Parents' Mentalization and Children Mental Health in General Population.
Status: RECRUITING
Conditions: Emotional Intelligence|Social Interaction|Mental Health Wellness 1|Well-Being, Psychological
Interventions: BEHAVIORAL: iMentalize Program (iMentalize)|BEHAVIORAL: Mediational Intervention for Sensitizing Caregivers, Self-Administered version (MISC-SA)|BEHAVIORAL: Mediational Intervention for Sensitizing Caregivers - Readings version (MISC-R): Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Intrusive Memories in Refugees and Asylum Seekers With PTSD: A Pilot Study
Status: TERMINATED
Conditions: Stress Disorders, Post-Traumatic|Stress Disorders, Traumatic|Mental Disorder|Trauma and Stressor Related Disorders
Interventions: BEHAVIORAL: Brief cognitive intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selumetinib in Treating Patients With Biliary Cancer That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Liver and Intrahepatic Biliary Tract Cancer|Recurrent Extrahepatic Bile Duct Cancer|Unresectable Extrahepatic Bile Duct Cancer
Interventions: DRUG: selumetinib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: QUANtification of Cardiovascular Autonomic Neuropathy (CAN) and the Effects of Anaesthesia on Haemodynamics and Cerebral Perfusion
Status: COMPLETED
Conditions: Anesthesia|Diabetes Mellitus, Type 2
Interventions: DIAGNOSTIC_TEST: Paced breathing at 6, 10 and 15 breaths per minute
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neurocircuit Strategy to Decrease Cocaine Cue Reactivity
Status: ACTIVE_NOT_RECRUITING
Conditions: Cocaine-Related Disorders
Interventions: DRUG: N-acetylcysteine|DEVICE: Theta-burst stimulation (TBS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Trial of Oral Ciprofloxacin and Etoposide in Subjects With Resistant Acute Myeloid Leukemia (AML)(UF-AML-CE-101)
Status: TERMINATED
Conditions: Leukemia|Acute Myelogenous Leukemia|Acute Myeloid Leukemia
Interventions: DRUG: Ciprofloxacin 750 MG|DRUG: Etoposide|DRUG: Ciprofloxacin 1000 MG|DRUG: Ciprofloxacin 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor-Derived Viral Specific T-cells (VSTs)
Status: RECRUITING
Conditions: Allogeneic Stem Cell Transplant|Viral Infection|Viral Reactivation
Interventions: BIOLOGICAL: Viral specific VST Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Subcutaneous (sc) Mircera in Dialysis Patients With Chronic Renal Anemia.
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: methoxy polyethylene glycol-epoetin beta [Mircera]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Edwards SAPIEN-3 Periprosthetic Leakage Evaluation Versus Medtronic CoreValve in Transfemoral Aortic Valve Implantation
Status: TERMINATED
Conditions: Periprosthetic Aortic Valve Regurgitation After TAVI
Interventions: PROCEDURE: Transcatheter aortic valve replacement|DEVICE: Medtronic CoreValve system|DEVICE: Edwards SAPIEN bioprosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Fluorine F 18 Fluorodopa-Labeled PET Scan in Planning Surgery and Radiation Therapy in Treating Patients With Newly Diagnosed High- or Low-Grade Malignant Glioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Adult Anaplastic Astrocytoma|Adult Anaplastic Ependymoma|Adult Anaplastic Oligodendroglioma|Adult Brain Stem Glioma|Adult Diffuse Astrocytoma|Adult Ependymoma|Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Adult Mixed Glioma|Adult Myxopapillary Ependymoma|Adult Oligodendroglioma|Adult Pilocytic Astrocytoma|Adult Pineal Gland Astrocytoma|Adult Subependymal Giant Cell Astrocytoma|Adult Subependymoma
Interventions: PROCEDURE: biopsy|PROCEDURE: computed tomography|PROCEDURE: therapeutic conventional surgery|RADIATION: radiation therapy treatment planning/simulation|RADIATION: radiation therapy|PROCEDURE: magnetic resonance imaging|PROCEDURE: positron emission tomography|DRUG: fluorine F 18 fluorodopa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neuromuscular Electroestimulation and Respiratory Muscle Training in Subacute Stroke
Status: COMPLETED
Conditions: Dysphagia
Interventions: PROCEDURE: RMT + usual care|PROCEDURE: NMES|PROCEDURE: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Product Duration of Use Experience With Alclometasone Dipropionate Cream
Status: COMPLETED
Conditions: Eczema|Allergy Symptoms|Psoriasis|Itch
Interventions: DRUG: Alclometasone dipropionate cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Safety & Efficacy of the Absolute Pro™ Peripheral Self-Expanding Stent System in Subjects With Atherosclerotic de Novo or Restenotic Lesions in the Native Common Iliac Artery and/or Native External Iliac Artery.
Status: COMPLETED
Conditions: Peripheral Vascular Disease
Interventions: DEVICE: Absolute Pro™ Peripheral Self-Expanding Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CM310 in Subjects With Allergic Rhinitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Allergic Rhinitis
Interventions: BIOLOGICAL: CM310|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Flourishing and Virtue in Cognitive-Behavioral Therapy for Anxiety and Depressive Disorders
Status: RECRUITING
Conditions: Anxiety Disorders|Depressive Disorder
Interventions: BEHAVIORAL: Unified Protocol|BEHAVIORAL: Modified Unified Protocol (UP+)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Cannabidiol Oral Solution (GWP42003-P, CBD-OS) in Patients With Rett Syndrome
Status: TERMINATED
Conditions: Rett Syndrome|RTT
Interventions: DRUG: GWP42003-P|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of The Oral Health Status of Children With Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Caries,Dental|Quality of Life|Saliva Altered|Periodontitis
Interventions: DIAGNOSTIC_TEST: physical and chemical methods|DIAGNOSTIC_TEST: biochemical methods|DIAGNOSTIC_TEST: biochemical tests|DIAGNOSTIC_TEST: Oral Health Habits|DIAGNOSTIC_TEST: Oral Findings|DIAGNOSTIC_TEST: Quality of Life Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination Chemotherapy in Treating Pain in Hormone Refractory Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Pain|Prostate Cancer|Quality of Life
Interventions: DRUG: clodronate disodium|DRUG: mitoxantrone hydrochloride|DRUG: prednisone|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of 100 mcg of Env 2-3 in MF59
Status: COMPLETED
Conditions: HIV Infections|HIV Seronegativity
Interventions: BIOLOGICAL: Env 2-3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Evaluation of 2-year Clinical Performance of Two Different Single Color Universal Composite Resin Restorative Materials.
Status: RECRUITING
Conditions: Tooth Discoloration|Tooth Wear
Interventions: PROCEDURE: Restoration with-tooth colored material
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Remediation for Social Cognition in Schizophrenia and Related Disorders
Status: RECRUITING
Conditions: Psychosis|Schizophrenia|Cognitive Impairment
Interventions: BEHAVIORAL: The program Remédiation Cognitive de la Cognition Sociale en Schizophrénie (RC2S+)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Office-sclerotherapy for Epistaxis Due to Hereditary Hemorrhagic Telangiectasia
Status: COMPLETED
Conditions: Epistaxis|Hereditary Hemorrhagic Telangiectasia
Interventions: DRUG: Sclerotherapy|OTHER: Standard Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Laparoscopic Treatment of Superficial Endometriosis for Managing Chronic Pelvic Pain
Status: COMPLETED
Conditions: Endometriosis|Pelvic Pain
Interventions: PROCEDURE: surgical removal of superficial peritoneal endometriosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: The Effect of Rhomboid Intercostal Block and Serratus Anterior Plane Block on Postoperative Respiratory Functions
Status: COMPLETED
Conditions: Breast Cancer|Postoperative Pain|Respiratory Function Impaired
Interventions: PROCEDURE: RIB+SAP blocks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of MCLA-129, a Human Bispecific EGFR and cMet Antibody, in Patients With Advanced NSCLC and Other Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor|Non-Small Cell Lung Cancer|Head and Neck Cancer|Colorectal Cancer
Interventions: DRUG: MCLA-129
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treating Wheezing in Children With Hypertonic Saline (TWICS)
Status: WITHDRAWN
Conditions: Wheeze
Interventions: OTHER: hypertonic saline|OTHER: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Phase II/III Trial of Ustekinumab to Treat Type 1 Diabetes (UST1D2)
Status: RECRUITING
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Ustekinumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-finding Study of QGE031 as add-on Therapy to Evaluate Efficacy and Safety in Patients With CSU
Status: COMPLETED
Conditions: Chronic Spontaneous Urticaria
Interventions: BIOLOGICAL: QGE031|BIOLOGICAL: Omalizumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TOPIC Trial for COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Ivacaftor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Nycthemeral Variations on Computed Tomography (CT) Parameters Reflecting Airways Remodelling, and Pulmonary Emphysema Extent in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: COPD|CT|Nycthemeron
Interventions: RADIATION: Chest CT scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Boceprevir in Previously Untreated Subjects With Chronic Hepatitis C Genotype 1 (Study P05216AM2) (COMPLETED)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: BIOLOGICAL: Peginterferon alfa-2b (PEG)|DRUG: Ribavirin (RBV)|DRUG: Placebo|DRUG: Boceprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Epicardial Delivery of XC001 Gene Therapy for Refractory Angina Coronary Treatment (The EXACT Trial)
Status: COMPLETED
Conditions: Coronary Artery Disease|Ischemia|Angina Refractory|Cardiovascular Diseases|Heart Diseases
Interventions: BIOLOGICAL: AdVEGFXC1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Re:Garde Program - Training and Maintaining Visual Perception in Older Adults
Status: RECRUITING
Conditions: Vision, Low|Visual Impairment
Interventions: DEVICE: HMD: Immersive VR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Curcumin as Nutraceutical in Patients of Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DIETARY_SUPPLEMENT: Curcumin|DRUG: Fluoxetine|DIETARY_SUPPLEMENT: Curcumin and Fluoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Avelumab and Talazoparib in Untreated Advanced Ovarian Cancer (JAVELIN OVARIAN PARP 100)
Status: TERMINATED
Conditions: Ovarian Cancer
Interventions: DRUG: Chemotherapy + avelumab followed by avelumab + talazoparib|DRUG: Chemotherapy followed by talazoparib maintenance|DRUG: Chemotherapy + bevacizumab followed by bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-center, Open-label, Phase 1b Clinical Trial to Evaluate the Safety, Tolerability, and Exploratory Efficacy of TEW-7197 in Combination With FOLFOX in Patients With Metastatic Pancreatic Ductal Adenocarcinoma Who Have Failed First-Line Gemcitabine and Nab-Paclitaxel
Status: UNKNOWN
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: TEW-7197
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of XY0206 Versus Salvage Chemotherapy In Patients With Relapsed or Refractory AML With FLT3-ITD-Mutation (ALIVE)
Status: NOT_YET_RECRUITING
Conditions: Acute Myeloid Leukemia With FLT3/ITD Mutation
Interventions: DRUG: XY0206|DRUG: Salvage Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Association Between Confocal Laser Endomicroscopic (CLE) Features and Gastric Mucosal Microbiome
Status: UNKNOWN
Conditions: Mucosal Microbiome|H.Pylori|Intestinal Metaplasia|Gastric Neoplasia
Interventions: OTHER: endomicroscopy, targeted biopsy and 16s rRNA gene sequencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Targeted Intervention Study of dTMS on Impaired Insight in Early Psychosis
Status: NOT_YET_RECRUITING
Conditions: Impaired Insight
Interventions: DEVICE: active-dTMS|DEVICE: sham-dTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Conventional Versus Rendezvous Technique of Intraoperative Endoscopic Retrograde Cholangiopancreatography
Status: COMPLETED
Conditions: Common Bile Duct Gallstones
Interventions: PROCEDURE: endoscopic sphincterotomy by conventional method|PROCEDURE: endoscopic sphincterotomy by rendezvous method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Assessing Compliance With Mercaptopurine Treatment in Younger Patients With Acute Lymphoblastic Leukemia in First Remission
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphoblastic Leukemia
Interventions: BEHAVIORAL: Behavioral Intervention|BEHAVIORAL: Compliance Monitoring|OTHER: Laboratory Biomarker Analysis|DRUG: Mercaptopurine|OTHER: Questionnaire Administration|PROCEDURE: Standard Follow-Up Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dermatologists' Educational Demonstration for Epiduo Application
Status: COMPLETED
Conditions: Facial Acne|Local Adverse Effects
Interventions: DRUG: Epiduo once daily with detailed instruction for how to apply it|DRUG: Epiduo- once daily, simple instruction for application|DRUG: BPO once daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomised, Multi-centre, Double-blind, Phase 3 Study to Observe the Effectiveness, Safety and Tolerability of Molnupiravir Compared to Placebo Administered Orally to High-risk Adult Outpatients With Mild COVID-19 Receiving Local Standard of Care in South Africa
Status: RECRUITING
Conditions: COVID-19
Interventions: DRUG: Molnupiravir 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of 12-week FW Programme on Sex Hormone Levels and Risk Factors for MS in Postmenopausal Women
Status: COMPLETED
Conditions: Postmenopause Women
Interventions: BEHAVIORAL: Fitness walking|BEHAVIORAL: Maintained lifestyle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Open-label Extension to Evaluate the Efficacy and Safety of the Rivastigmine Transdermal Patch in Patients With Probable Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Rivastigmine Transdermal Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study of Oral Cyclophosphamide and Topotecan in Children With Recurrent Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Cyclophosphamide and Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NEAT!2 Sedentary Behavior Reduction for Individuals With Past or Present Knee Symptoms, Injuries, or Surgeries
Status: TERMINATED
Conditions: Sedentary Lifestyle|Knee Osteoarthritis|Knee Injuries|Knee Pain Chronic
Interventions: BEHAVIORAL: NEAT!2|BEHAVIORAL: NEAT!2+Calls|BEHAVIORAL: Delayed NEAT!2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Crux Biomedical IVC Filter - Evaluation of the Crux Inferior Vena Cava Filter System (Retrieve)
Status: COMPLETED
Conditions: Pulmonary Embolism
Interventions: DEVICE: inferior vena cava filter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of NGR-hTNF in Combination With Doxorubicin in Patients Affected by Advanced or Metastatic Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer Metastatic Recurrent
Interventions: DRUG: NGR-hTNF|DRUG: doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diabetic Nephropathy in People With Diabetes. Prevalence and Predictive Factors
Status: RECRUITING
Conditions: Chronic Kidney Diseases|Albuminuria|Diabetic Kidney Disease|Diabetic Nephropathies|Diabetes type2|Molecular Sequence Variation|Kidney Biopsy
Interventions: PROCEDURE: Kidney Biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Pain on Functional Impairment and Quality of Life in Adults With Hemophilia
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A|Haemophilia A With Inhibitors|Haemophilia B|Haemophilia B With Inhibitors
Interventions: OTHER: No treatment given
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Explore Pharmacodynamic Effects of BIIB104 on Brain Circuitry in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Placebo|DRUG: BIIB104
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Investigating the Safety, Tolerability, Immunogenicity and Pharmacokinetics of Olamkicept in Healthy Persons
Status: RECRUITING
Conditions: Inflammatory Gastrointestinal Diseases
Interventions: DRUG: Olamkicept Part A|DRUG: Olamkicept Part B|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Everolimus in Restoring Salivary Gland Function in Participants With Locally Advanced Head and Neck Cancer Treated With Radiation Therapy
Status: TERMINATED
Conditions: Salivary Gland Dysfunction|Xerostomia|Head and Neck Cancer
Interventions: DRUG: Everolimus|OTHER: Laboratory Biomarker Analysis|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Freeze-Dried Black Raspberries in Preventing Oral Cancer Recurrence in High At-Risk Appalachian Patients Oral Cancer Survivors
Status: COMPLETED
Conditions: Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage I Squamous Cell Carcinoma of the Oropharynx|Stage I Verrucous Carcinoma of the Oral Cavity|Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage II Squamous Cell Carcinoma of the Oropharynx|Stage II Verrucous Carcinoma of the Oral Cavity|Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage III Squamous Cell Carcinoma of the Oropharynx|Stage III Verrucous Carcinoma of the Oral Cavity|Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVA Squamous Cell Carcinoma of the Oropharynx|Stage IVA Verrucous Carcinoma of the Oral Cavity|Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVB Squamous Cell Carcinoma of the Oropharynx|Stage IVB Verrucous Carcinoma of the Oral Cavity|Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVC Squamous Cell Carcinoma of the Oropharynx|Stage IVC Verrucous Carcinoma of the Oral Cavity|Tongue Cancer
Interventions: DIETARY_SUPPLEMENT: BRB Lozenge|OTHER: Survey Administration|OTHER: Laboratory Biomarker Analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Efficacy and Safety of Anakinra in the Treatment of Still's Disease (SJIA and AOSD)
Status: TERMINATED
Conditions: Still's Disease, Adult-Onset|Still's Disease, Juvenile-Onset
Interventions: BIOLOGICAL: anakinra|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of V116 in Pneumococcal Vaccine-naïve Adults (V116-003, STRIDE-3)
Status: COMPLETED
Conditions: Pneumococcal Infection
Interventions: BIOLOGICAL: V116|BIOLOGICAL: PCV20
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Prebiotics on the Microbiome in Irritable Bowel Syndrome Patients: The Diet and Microbiome Study
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Factor Altered Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HealthSmart: Promoting Healthy Lifestyles for Young Adult Cancer Survivors Using Educational Videos
Status: COMPLETED
Conditions: Environmental Exposure to Ultraviolet Light
Interventions: OTHER: THE INFORMATION + APPEARANCE VIDEO|OTHER: Information SunSmart video|OTHER: Sleep hygiene video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Renal Hemodynamic Effects of RLX030A in Subjects With Chronic Heart Failure (CHF)
Status: COMPLETED
Conditions: Chronic Heart Failure (CHF)
Interventions: DRUG: RLX030|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Body Temperature Measurement Using Infrared Camera: Comparison With Esophageal, and Skin Temperatures
Status: UNKNOWN
Conditions: Patients Undergoing General Anesthesia
Interventions: DEVICE: Infrared Camera|DEVICE: Esophageal Temperature Probe|DEVICE: Skin temperature probe
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LEZ763
Status: COMPLETED
Conditions: Type II Diabetes
Interventions: DRUG: Placebo|DRUG: Sitagliptin|DRUG: LEZ763
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Reducing the Dose of Stavudine Versus Switching to Tenofovir in HIV-Infected Patients Receiving Antiretroviral Therapy
Status: COMPLETED
Conditions: HIV Infections|Lipoatrophy
Interventions: DRUG: switching; dose reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CuATSM Compared With Placebo for Treatment of ALS/MND
Status: UNKNOWN
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Cu(II)ATSM|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Different Doses of BI 1831169 Alone and in Combination With an Anti-PD-1 Antibody in People With Different Types of Advanced Cancer (Solid Tumors)
Status: RECRUITING
Conditions: Solid Tumors
Interventions: DRUG: BI 1831169|DRUG: anti-PD-1 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Blood Flow Restriction Training in Adolescents After ACL Reconstruction: A Randomized Controlled Trial
Status: RECRUITING
Conditions: Anterior Cruciate Ligament Injuries|Knee Injuries|Quadriceps Muscle Atrophy
Interventions: DEVICE: Blood Flow Restriction using Delfi Personalized Tourniquet System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Immunotherapy in Sepsis
Status: ACTIVE_NOT_RECRUITING
Conditions: Sepsis
Interventions: DRUG: Anakinra or rhIFNγ|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Dose Study of Intravenous Infusion of PF 07304814 in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-07304814|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pathological and Non-pathological Aging, Physical Activity, Genotype and Cognition
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: BEHAVIORAL: Combination of aerobic and strength exercises|BEHAVIORAL: Stretching and balance exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Unilateral Sequential Sympathectomy for Palmar Hyperhidrosis
Status: COMPLETED
Conditions: Palmar Hyperhidrosis
Interventions: PROCEDURE: bilateral simultaneous endoscopic thoracic symapthectomy|PROCEDURE: unilateral sequential endoscopic thoracic symapthectomy.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Inhalatory Sedation in Subarachnoid Hemorrhage
Status: COMPLETED
Conditions: Subarachnoid Hemorrhage|Aneurysmal Subarachnoid Hemorrhage
Interventions: DRUG: Isoflurane Inhal Soln
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Barberry and Cardiometabolic Risk Factors in Individuals With Hypertriglyceridemia
Status: NOT_YET_RECRUITING
Conditions: Hyperlipidemias|Hypertriglyceridemia
Interventions: OTHER: Dried barberry|OTHER: Low-calorie diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Immunology and Safety of Menactra® in Children in Saudi Arabia
Status: COMPLETED
Conditions: Meningitis|Meningococcemia
Interventions: BIOLOGICAL: Menactra®: Meningococcal Polysaccharide Diphtheria Toxoid Conjugate|BIOLOGICAL: Menactra®: Meningococcal Polysaccharide Diphtheria Toxoid Conjugate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Efficacy and Safety Study w/ Azstarys® in Children With ADHD
Status: COMPLETED
Conditions: Attention Deficit/Hyperactivity Disorder
Interventions: DRUG: Serdexmethylphenidate (SDX) and dexmethylphenidate (d-MPH)|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Laparoskopic Uterosacral Ligament and Round Ligament Plication, A Meshless Method in the Surgical Treatment of Pelvic Organ Prolapse.
Status: UNKNOWN
Conditions: Pelvic Organ Prolapse|Prolapse Uterus|Prolapse Bladder
Interventions: PROCEDURE: Combination of Laparoscopic Uterosacral Ligament and Round Ligament Plication.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Efficacy and Safety of Herbal Medicine for Treating Work-related Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain|Workplace
Interventions: DRUG: Sogyeonghwalhyeol-tang|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Denosumab Plus Enzalutamide, Abiraterone and Prednisone Compared to Denosumab Plus Enzalutamide Alone for Men With Castrate Resistant Prostate Cancer (CRPC) With Bone Metastases
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: Denosumab|DRUG: Enzalutamide|DRUG: Abiraterone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Latarjet Procedure: Comparative Outcomes Study of Arthroscopic Versus Mini-open Approach With Minimum 2-year Follow-up
Status: COMPLETED
Conditions: Joint Instability
Interventions: PROCEDURE: Arthroscopic Latarjet procedure|PROCEDURE: Mini-open Latarjet procedure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Vanadium Supplement in Patients With Impaired Glucose Tolerance
Status: COMPLETED
Conditions: Prediabetic State
Interventions: DIETARY_SUPPLEMENT: Vanadyl sulfate|OTHER: Magnesium oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Near Infrared (NIR) Autofluorescence Image-guided Thyroid Surgery
Status: UNKNOWN
Conditions: Hypoparathyroidism Postprocedural|Hypocalcemia|Surgery--Complications
Interventions: DEVICE: NIR optical imaging camera
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of 2 Doses of Oral Live Attenuated Human Rotavirus (HRV) Vaccine for the Prophylaxis of Rotavirus Gastroenteritis
Status: COMPLETED
Conditions: Infections, Rotavirus
Interventions: BIOLOGICAL: Live attenuated human rotavirus vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Chemoradiotherapy of NSCLC Stage IIIB
Status: COMPLETED
Conditions: NSCLC Stage IIIB|Concomitant Radiochemotherapy
Interventions: DRUG: Paclitaxel, vinorelbine, cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Romiplostim (AMG 531) Versus Medical Standard of Care for Immune (Idiopathic) Thrombocytopenic Purpura
Status: COMPLETED
Conditions: Idiopathic Thrombocytopenic Purpura|Thrombocytopenia|Thrombocytopenia in Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP)|Thrombocytopenic Purpura
Interventions: DRUG: Medical Standard of Care for ITP|BIOLOGICAL: Romiplostim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effectiveness of Acceptance and Commitment Therapy for Distress Following Psychosis
Status: COMPLETED
Conditions: Psychosis|Schizophrenia|Bipolar Disorder|Schizo-affective Disorder
Interventions: OTHER: Acceptance and Commitment Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magna® Mitral Pericardial Bioprostheses Post-Approval Study Protocol
Status: COMPLETED
Conditions: Coronary Artery Disease|Mitral Valve Regurgitation|Mitral Valve Incompetence|Heart Failure
Interventions: DEVICE: CEP MAGNA MITRAL PERICARDIAL BIOPROSTHESES
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FRESH-DOSE: Families Responsibility Education Support Health-Dual Options for Sustained Effectiveness
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: BEHAVIORAL: Family Based Behavioral Treatment|BEHAVIORAL: Guided Self-Help Fam. Based Bx Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-determining and Dose-confirmatory Study to Investigate the Optimal Dose of Tamoxifen in Breast Cancer Patients According to Genotype Status of TCF20 rs932376
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Tamoxifen|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Fixed Dose Study of Ropinirole Prolonged Release as Adjunctive Treatment in Patients With Advanced Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: ropinirole/L-dopa|DRUG: placebo/L-dopa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: High-dose Ascorbic Acid Intravenous Injection Decreases Mitochondrial DNA Damage in Chronic Fatigue Patients: Randomized-controlled Study
Status: UNKNOWN
Conditions: Chronic Fatigue
Interventions: DRUG: ascorbic acid 10g/20ml|DRUG: Normal Saline 150ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Obstructive Sleep Apnea Syndrome in Sarcoidosis and Impact of CPAP Treatment on Associated Fatigue Status
Status: COMPLETED
Conditions: Sarcoidosis|Sleep Apnea, Obstructive|Fatigue
Interventions: DEVICE: Continuous Positive Airway Pressure (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Field Administration of Stroke Therapy - Magnesium (FAST-MAG) Trial
Status: COMPLETED
Conditions: Cerebrovascular Accident
Interventions: DRUG: Magnesium Sulfate|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Sleeve Gastrectomy Technique With a Nissen Fundoplication Added to the Conventional Sleeve Gastrectomy Technique in Morbidly Obese Patients
Status: TERMINATED
Conditions: Severe Obesity|GERD|Bariatric Surgery Candidate|Morbid Obesity
Interventions: PROCEDURE: N-SLEEVE technique|PROCEDURE: SLEEVE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Electroencephalogram (EEG) Triggered Functional Magnetic Resonance Imaging (fMRI) in Epilepsy Patients
Status: COMPLETED
Conditions: Epilepsy
Interventions: OTHER: EEG Triggered fMRI using Micro Maglink
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Home-fortification With Sprinkles in Hematologic and Nutritional Status in Preschool Children in Medellín
Status: UNKNOWN
Conditions: Malnutrition
Interventions: DIETARY_SUPPLEMENT: Sachets containing a blend of micronutrients in powder form (Iron, Zinc, Folic Acid, Vitamin A and C), sprinkled onto home made food|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: May Noninvasive Mechanical Ventilation (NIV) and/or Continuous Positive Airway Pressure (CPAP) Increase the Bronchoalveolar Lavage (BAL) Salvage in Patients With Pulmonary Diseases?
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease|Interstitial Lung Disease
Interventions: PROCEDURE: BAL + PAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Influence of Walking Pilgrimage on Changes in Body Composition, Biochemical Parameters, Circulatory and Respiratory Efficiency and Foot Biomechanics in Healthy Women and Men of All Ages.
Status: COMPLETED
Conditions: Cardiovascular Diseases|Health Behavior|Foot Injuries and Disorders|Skin Condition
Interventions: OTHER: multi day walking
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Maintenance and Tissues Conditions of Fixed Screw-Retained Implant Prosthesis Versus Implant-Retained Ball Overdentures
Status: COMPLETED
Conditions: Prosthesis and Implant Dentistry
Interventions: PROCEDURE: Screw retained restoration|PROCEDURE: implant-retained ball overdentures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetic Study of Lumacaftor/Ivacaftor in Subjects Aged 2 Through 5 Years With Cystic Fibrosis, Homozygous for F508del
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: LUM/IVA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of EOS-448 With Standard of Care and/or Investigational Therapies in Participants With Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Cancer|Lung Cancer|Head and Neck Cancer|Melanoma
Interventions: DRUG: EOS-448|DRUG: pembrolizumab|DRUG: inupadenant|DRUG: Dostarlimab|DRUG: SOC chemotherapies
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT