pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Non-invasive Ventilation for Extubation Success in Infants Less Than 1,250 Grams
Status: UNKNOWN
Conditions: Respiratory Failure
Interventions: DEVICE: BP-NCPAP|DEVICE: NIHFV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HER3-DXd in Metastatic or Unresectable Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer (NSCLC)
Interventions: DRUG: HER3-DXd (FL-DP)|DRUG: HER3-DXd (CTM-1 Lyo-DP)|DRUG: HER3-DXd (CTM-3 Lyo-DP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First Study in Humans With GSK424887
Status: COMPLETED
Conditions: Depressive Disorder and Anxiety Disorders
Interventions: DRUG: GSK424887|DRUG: Placebo|RADIATION: PET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Measuring the Effect of Dupilumab Treatment on Mucociliary Clearance (MCC) in Subjects With Moderate to Severe Asthma
Status: RECRUITING
Conditions: Asthma
Interventions: DRUG: Dupilumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of SK-1404 for Nocturia Due to Nocturnal Polyuria in Japanese Subjects
Status: COMPLETED
Conditions: Nocturia Due to Nocturnal Polyuria
Interventions: DRUG: SK-1404|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Glesatinib, Sitravatinib or Mocetinostat in Combination With Nivolumab in Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Glesatinib|DRUG: Sitravatinib|DRUG: Mocetinostat|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Fish Oil in Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing- Remitting Multiple Sclerosis
Interventions: DIETARY_SUPPLEMENT: Fish Oil|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Open Label, Prospective, Non-Randomized Study Of INCRAFT™ In Subjects With AAA (INNOVATION)
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysms
Interventions: DEVICE: Cordis AAA stent graft system "INCRAFT TM"
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gefitinib and Radiation Therapy in Treating Children With Newly Diagnosed Gliomas
Status: COMPLETED
Conditions: Untreated Childhood Anaplastic Astrocytoma|Untreated Childhood Anaplastic Oligodendroglioma|Untreated Childhood Brain Stem Glioma|Untreated Childhood Giant Cell Glioblastoma|Untreated Childhood Glioblastoma|Untreated Childhood Gliomatosis Cerebri|Untreated Childhood Gliosarcoma|Untreated Childhood Oligodendroglioma
Interventions: DRUG: gefitinib|RADIATION: radiation therapy|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Empagliflozin on Cardiac-renal Injury in Patients With STEAMI Patients After Primary PCI
Status: UNKNOWN
Conditions: Reperfusion Injury, Myocardial
Interventions: DRUG: Empagliflozin|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Function in Patients With Persisted Atrial Fibrillation
Status: ENROLLING_BY_INVITATION
Conditions: Atrial Fibrillation, Persistent|Cognitive Function
Interventions: OTHER: Rhythm control|OTHER: Rate control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: cisplatin|DRUG: fluorouracil|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Atomoxetine Treatment for Cognitive Impairment in Parkinson's Disease (ATM-Cog)
Status: COMPLETED
Conditions: Parkinson's Disease|Cognitive Impairment
Interventions: DRUG: Atomoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Valette (Combined Oral Contraceptive SH T04769G and SH D00659AF) Low Ovulation Inhibition
Status: COMPLETED
Conditions: Oral Contraceptive
Interventions: DRUG: SH T04769G|DRUG: Ethinyl estradiol / dienogest (SH D00659 AF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Inhibitory Effect of Metformin on Gluconeogenesis in Relation to Polymorphisms in Organic Cation Transporter 1
Status: COMPLETED
Conditions: Pharmacogenetics of Metformin
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: MK-0954E Study in Participants With Hypertension (MK-0954E-357)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: losartan potassium + hydrochlorothiazide + amlodipine besylate (MK-0954E)|DRUG: Losartan potassium|DRUG: Amlodipine besylate|DRUG: Placebo to MK-0954E|DRUG: Placebo to losartan potassium|DRUG: Placebo to amlodipine besylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 STIR Trial: Haploidentical Transplant and Donor Natural Killer Cells for Solid Tumors
Status: COMPLETED
Conditions: Ewing Sarcoma|Neuroblastoma|Rhabdomyosarcoma|Osteosarcoma|CNS Tumors
Interventions: PROCEDURE: Allogeneic HCT|DRUG: Donor NK Cell Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Potassium Kinetic During and After Hemodialysis and Potassium Profiling to Prevent Arrhythmias
Status: RECRUITING
Conditions: Hemodialysis Complication|Arrhythmias|Potassium Imbalance
Interventions: DEVICE: Hemodialysis with online HFR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Coconut Sugar Lowers Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults
Status: COMPLETED
Conditions: Aging|Blood Pressure|Arterial Stiffness
Interventions: DIETARY_SUPPLEMENT: Coconut Sap Powder (CSP)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Amiloride and Hypertonic Saline in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: 7% NaCl|DRUG: Amiloride HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: Customized Masks in Non-Invasive Mechanical Ventilation
Status: RECRUITING
Conditions: COPD, Severe Early-Onset|Ventilatory Failure|Als|Non Invasive Ventilation
Interventions: DEVICE: 3d printed mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of IPH: Electric Warming Mattress vs Forced Air Warming Blanket
Status: COMPLETED
Conditions: Inadvertent Perioperative Hypothermia|Patient Warming
Interventions: OTHER: warming mattress|OTHER: warming blanket
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Nab-paclitaxel in Combination With Gemcitabine for Pediatric Relapsed and Refractory Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer
Interventions: DRUG: Gemcitabine|DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Interventions Related to Dialysis Procedures in Order to Reduce Cardiovascular Morbidity and Mortality in HD Patients(EGESTUDY)
Status: COMPLETED
Conditions: End-stage Renal Disease|Hemodialysis
Interventions: PROCEDURE: high-flux membrane|PROCEDURE: low-flux membrane|PROCEDURE: conventional dialysate|PROCEDURE: ultrapure dialysate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Imaging of Inflammation in Parkinson's Disease Using LPS and TSPO-PET/MR
Status: RECRUITING
Conditions: Neurodegenerative Diseases|Parkinson Disease
Interventions: DRUG: Lipopolysaccharide|RADIATION: PET/MR with [11C]PBR28
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vitamin D3 Combined With Strengthening Exercise for Lateral Epicondylitis of Elbow
Status: RECRUITING
Conditions: Lateral Epicondylitis of Elbow
Interventions: DRUG: Vitamin D3 or Saline injection at ipsilateral deltoid muscle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TPF Plus Cisplatin and Radiotherapy vs TPF Plus Cetuximab and Radiotherapy to Treat Head and Neck Cancer.
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: OTHER: TPF, radiotherapy and cisplatin.|OTHER: TPF, radiotherapy and cetuximab.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long-term Safety Study of Fluticasone Furoate (FF)/GW642444 in Japanese Subjects With COPD
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Fluticasone Furoate/GW642444 Inhalation Powder 100/25mcg|DRUG: Fluticasone Furoate/GW642444 Inhalation Powder 200/25mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, Tolerability, and Pharmacokinetics of Sotrastaurin Combined With Tacrolimus vs. a Mycophenolic Acid-tacrolimus Regimen in Renal Transplant Patients
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: sotrastaurin (Dose 1) + tacrolimus + standard of care medications|DRUG: sotrastaurin (Dose 2) + tacrolimus + standard of care medications|DRUG: sotrastaurin (Dose 3) + tacrolimus + standard of care medications|DRUG: mycophenolic acid + tacrolimus + standard of care medications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of BL-B01D1 in Patients With Locally Advanced or Metastatic Gastrointestinal Tumor and Other Solid Tumor
Status: RECRUITING
Conditions: Gastrointestinal Tumor
Interventions: DRUG: BL-B01D1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation and Dissemination of an Evidence-Based Tobacco Product Use Prevention Videogame Intervention With Adolescents
Status: COMPLETED
Conditions: Smoking Cessation|Smoking
Interventions: DEVICE: smokeSCREEN web-based game
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: BABEL Advance Care Planning in Long-term Care
Status: COMPLETED
Conditions: Nursing Homes|Aged|Frail Elderly Syndrome|Dementia|Chronic Disease
Interventions: OTHER: The BABEL Approach to Advance Care Planning in Nursing Homes|OTHER: Control group Advance Care Planning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Paediatric Infections Point-Of-Care
Status: COMPLETED
Conditions: Meningitis|Pediatric Infectious Diseases
Interventions: DIAGNOSTIC_TEST: Multiplex PCR assay for meningitis|DIAGNOSTIC_TEST: Multiplex vertical flow microarrray assay for meningitis|DIAGNOSTIC_TEST: Profiling of blood proteins by multi-analyte Profiling technology|OTHER: Typing and whole genome sequencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of 8.5 F Plastic Stent Without Proximal Flap on Prevention of Post-ERCP Cholangitis
Status: COMPLETED
Conditions: Cholangitis|Complication
Interventions: DEVICE: endoscopic retrograde biliary drainage|DEVICE: endoscopic nasobiliary drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Tc 99m Tilmanocept Imaging With IHC Analysis of CD206 Expression in Synovial Tissue of Subjects With RA
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tc 99m tilmanocept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pressure Injury Prediction and Education Model Using a Mobile Application System
Status: UNKNOWN
Conditions: Pressure Injury|Wound
Interventions: DEVICE: The Pressure Injury Prediction and Education model using a mobile application system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Observational Prospective Study to Identify Intestinal Microbial Profiles in Newly Diagnosed Crohn's Disease Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn Disease
Interventions: OTHER: Collection biological sample and analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Maternal/Infant Peripartum NVP, Versus Infant Only Peripartum NVP, or Maternal LPV/r in Addition to Standard ZDV Prophylaxis for the Prevention of Perinatal (PMTCT) HIV in Thailand
Status: TERMINATED
Conditions: HIV Infections|Pregnancy
Interventions: DRUG: Maternal and infant nevirapine|DRUG: Maternal placebo and infant nevirapine|DRUG: Maternal lopinavir+ritonavir|DRUG: zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Second Generation Antipsychotics in First Episode Psychosis Patients: 1-year Follow-up
Status: UNKNOWN
Conditions: Schizophrenia|Psychotic Disorders
Interventions: DRUG: Aripiprazole|DRUG: Risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intranasal Insulin Improves Postoperative Neurocognitive Disorders in Elderly Patients
Status: RECRUITING
Conditions: Postoperative Neurocognitive Disorders
Interventions: DRUG: Intranasal insulin|DRUG: Intranasal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of "Cerclage Pacing" for the Heart Failure Patients Who Need Cardiac Resynchronization Therapy (CRT)
Status: COMPLETED
Conditions: Heart Failure|LBBB Complete
Interventions: DEVICE: Medtronic 4196 lead
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase IV to Evaluate the Safety of Self-administered ADASUVE® in Agitated Patients Outside the Hospital Setting
Status: COMPLETED
Conditions: Agitation
Interventions: DEVICE: Staccato® Delivery System Loxapine (ADASUVE®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Team Sports on the Risk of Thrombosis in Elderly Individuals in a Municipality Setting (TEAM-AGE)
Status: NOT_YET_RECRUITING
Conditions: Thrombosis|Exercise Training|Sex Differences
Interventions: OTHER: Team Sports|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Early Tracheostomy in Ventilated Stroke Patients
Status: COMPLETED
Conditions: Ischemic Stroke|Intracerebral Hemorrhage|Subarachnoid Hemorrhage
Interventions: PROCEDURE: Early Tracheostomy|PROCEDURE: Late Tracheostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Dose Study of MK-8266 (MK-8266-001)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: MK-8266 0.1 mg|DRUG: MK-8266 1.0 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: EFFECT OF DEXMEDETOMİDİNE AND MİDAZOLAM SEDATİON ON HEART RATE VARİABİLİTY AFTER CORONARY ARTERY BYPASS GRAFT SURGERY
Status: UNKNOWN
Conditions: Effect of Sedation on Heart Rate Variability
Interventions: DRUG: Precedex 200 MCG in 2 ML Injection|DRUG: DORMICUM 5MG/5 ML
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mosunetuzumab With Chemotherapy for the Treatment of Patients With Untreated C-Myc Rearrangement Positive High Grade B Cell Lymphoma or Diffuse Large B Cell Lymphoma
Status: RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma|High Grade B-Cell Lymphoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration and Biopsy|PROCEDURE: Computed Tomography|DRUG: Cyclophosphamide|DRUG: Doxorubicin|PROCEDURE: Echocardiography|DRUG: Etoposide|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Mosunetuzumab|PROCEDURE: Multigated Acquisition Scan|PROCEDURE: Positron Emission Tomography|DRUG: Prednisone|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Linaclotide Capsule in Bowel Preparation for Patients at High Risk of Inadequate Bowel Preparation
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: 3 L PEG + linaclotide|DRUG: 3 L PEG + placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of LP-003 in Moderate-to-severe Seasonal Allergic Rhinitis Adult
Status: RECRUITING
Conditions: Seasonal Allergic Rhinitis
Interventions: BIOLOGICAL: LP-003 dose 1|BIOLOGICAL: LP-003 dose 2|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Mindfulness and Compassion Intervention for Pregnant Women and Their Partners for the Prevention of Stress and Depression During Pregnancy and Breastfeeding
Status: COMPLETED
Conditions: Pregnancy, Childbirth and Postpartum
Interventions: BEHAVIORAL: Mindfulness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Self-Obtained Ultrasound Scans for Measurement of Cervical Dilation and Effacement in Labor
Status: COMPLETED
Conditions: Cervical Dilation
Interventions: DIAGNOSTIC_TEST: Digital Cervical Exam|DIAGNOSTIC_TEST: Transperineal Ultrasound|DIAGNOSTIC_TEST: Transvaginal Ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Orca-T Following Chemotherapy and Total Marrow and Lymphoid Irradiation for the Treatment of Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia or Myelodysplastic Syndrome
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Dual-Energy Computed Tomography|PROCEDURE: Echocardiography|DRUG: Fludarabine|PROCEDURE: Magnetic Resonance Imaging|DRUG: Melphalan|PROCEDURE: Multigated Acquisition Scan|BIOLOGICAL: Partially Engineered T-regulatory Cell Donor Graft TRGFT-201|DRUG: Tacrolimus|DRUG: Thiotepa|RADIATION: Total Marrow and Lymphoid Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pneumococcal Conjugate Vaccine 13 (Prevnar13®) in Children Who Are Solid Organ Transplant Recipients (SOT)
Status: ACTIVE_NOT_RECRUITING
Conditions: Infection in Solid Organ Transplant Recipients
Interventions: BIOLOGICAL: Pneumococcal Conjugate Vaccine 13 (PCV13)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Epigenetic Regulation in Fibrous Dysplasia of Bone: mirDYS Study.
Status: RECRUITING
Conditions: Fibrous Dysplasia of Bone
Interventions: OTHER: Blood sample|OTHER: Waste bone tissue
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Magnesium on Remifentanil Induced Cough
Status: UNKNOWN
Conditions: Cough
Interventions: DRUG: Magnesium sulfate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: AL-38583 Ophthalmic Solution for Allergic Conjunctivitis Associated Inflammation
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: AL-38583 ophthalmic solution|DRUG: AL-38583 ophthalmic solution vehicle|DRUG: Dexamethasone ophthalmic suspension, 0.1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intermittent ThetaBurst Stimulation Compared to 10 Hz Stimulation on Dorsolateral Prefrontal Cortex in Treatment Resistant Major Depressive Disorder: a Double-blind Randomized Study
Status: COMPLETED
Conditions: DEPRESSION
Interventions: DEVICE: Transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Comparisons of One-stage Stone Removal in Mild and Moderate Cholangitis
Status: COMPLETED
Conditions: Cholangitis; Choledocholithiasis
Interventions: BEHAVIORAL: One stage treatment for mild and moderate cholangitis with choledocholithiasis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Meningococcal ACYW135 Polysaccharide Conjugate Vaccine in Healthy Volunteers Aged Above 3 Months
Status: UNKNOWN
Conditions: Meningitis, Meningococcal
Interventions: BIOLOGICAL: Meningococcal ACYW135 Polysaccharide Conjugate Vaccine|BIOLOGICAL: Meningococcal ACYW135 Polysaccharide Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Assess MEDI -578 in Patients With Osteoarthritis (OA) of the Knee
Status: TERMINATED
Conditions: Osteoarthritis|Pain
Interventions: DRUG: MEDI-578|DRUG: Placebo for MEDI-578
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 99Tc-MDP for Thyroid-Associated Ophthalmopathy
Status: COMPLETED
Conditions: Thyroid-Associated Ophthalmopathy
Interventions: DRUG: Methylprednisolone|DRUG: 99Tc-MDP(99Technetium-Methylenediphosphonate Injection)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Chewing Gum, Snacking and Appetite
Status: COMPLETED
Conditions: Hunger
Interventions: DIETARY_SUPPLEMENT: Chewing Gum|DIETARY_SUPPLEMENT: No Gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Aspirin for Prevention of Preeclampsia in Healthy, Nulliparous Obese and Overweight Pregnant Women
Status: UNKNOWN
Conditions: Preeclampsia
Interventions: DRUG: Aspirin 162 mg|DRUG: Aspirin 81 mg|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Once Daily Dosing of Lonafarnib Co-administered With Ritonavir for Treatment of Chronic Hepatitis D Virus Infection
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatitis D, Chronic
Interventions: DRUG: Lonafarnib|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Use of Fat Flap Reconstruction to Reduce Neck Injury After Cancer Treatment
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: OTHER: HRQOL instruments|OTHER: LENT SOMA instrument
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy of Ophthalmic Solution in Seasonal Allergic Conjunctivitis
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: R89674 0.025% ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases
Status: RECRUITING
Conditions: Brain Metastases
Interventions: DRUG: Memantine|RADIATION: Hippocampal-avoidant (HA-WBRT) Radiotherapy|PROCEDURE: Stereotactic Radiosurgery (SRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: United States Pre-Market Tobacco Application Pharmacokinetics
Status: COMPLETED
Conditions: Nicotine Dependence|Nicotine Dependence, Cigarettes|Tobacco Use|Tobacco Smoking
Interventions: OTHER: Virginia Tobacco flavored JUUL 5% ENDS|OTHER: Cool Mint flavored JUUL 5% ENDS|OTHER: Mango flavored JUUL 5% ENDS|OTHER: Creme Brulee flavored JUUL 5% ENDS|OTHER: VUSE Solo e-cigarette|OTHER: Nicorette White Ice Mint 4mg nicotine polacrilex gum|OTHER: Usual Brand combustible cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase 1b Trial to Evaluate Safety of MB097 in Combination With Pembrolizumab in Melanoma Patients
Status: NOT_YET_RECRUITING
Conditions: Melanoma
Interventions: BIOLOGICAL: MB097|BIOLOGICAL: Pembrolizumab|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Tenofovir Disoproxil Fumarate (TDF) and Emtricitabine/TDF in HIV Infected Pregnant Women and Their Infants
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Emtricitabine/Tenofovir disoproxil fumarate|DRUG: Tenofovir disoproxil fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Determine the Pharmacokinetic (PK) Bioequivalence of ABP 501 and Adalimumab (Humira®) in Healthy Adult Japanese Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: ABP 501|DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neoadjuvant FOLFIRINOX or Nab-paclitaxel With Gemcitabine for Borderline Resectable Pancreatic Cancer
Status: UNKNOWN
Conditions: Borderline Resectable Pancreatic Cancer
Interventions: DRUG: FOLFIRINOX|DRUG: gemcitabine + nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Versus Fentanyl for Sedation of Postoperative Mechanically Ventilated Neonates
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Dexmedetomidine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Jailed Wire Technique in the Treatment of Coronary Bifurcations Lesions With Stent: Stereoscopic Microscopy Study
Status: COMPLETED
Conditions: Coronary Health Disease
Interventions: DEVICE: Drug-Eluting Stents implantation in bifurcation lesions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Assess the Efficacy, Safety, and Tolerability of Vixarelimab in Reducing Pruritus in Prurigo Nodularis
Status: COMPLETED
Conditions: Prurigo Nodularis|Pruritis
Interventions: DRUG: vixarelimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men to Test How BI 1810631 is Taken up and Processed by the Body
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1810631 (C-14) formulation 1|DRUG: BI 1810631|DRUG: BI 1810631 (C-14) formulation 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilates Exercise Program for Improving Core Strength, Balance and Functional Autonomy in Aged Women
Status: COMPLETED
Conditions: Healthy Aged Women
Interventions: OTHER: Pilates exercise|OTHER: Muscular exercise|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Differential Effects of Ergocalciferol and Cholecalciferol Therapies in Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DIETARY_SUPPLEMENT: Vitamin D2 (ergocalciferol)|DIETARY_SUPPLEMENT: Vitamin D3 (cholecalciferol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multiple Dose Study of LY2541546 in Healthy Postmenopausal Women
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY2541546 - SC|DRUG: LY2541546 - IV|DRUG: Placebo - SC|DRUG: Placebo - IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Orthostatic Hypotension in Autonomic Failure
Status: COMPLETED
Conditions: Autonomic Failure|Orthostatic Hypotension
Interventions: DRUG: Atomoxetine|DRUG: Acarbose|DRUG: Pyridostigmine Bromide|DRUG: Yohimbine|DRUG: Midodrine HCl|DRUG: placebo|DRUG: Modafinil|DRUG: Octreotide|OTHER: water intake|DRUG: Diphenhydramine Hydrochloride|DRUG: Ranitidine HCL|DRUG: Tranylcypromine|DRUG: Ergotamine/ Caffeine|DRUG: Celecoxib|DRUG: Pseudoephedrine|DRUG: Methylphenidate|DRUG: Indomethacin|DRUG: Ibuprofen|DRUG: Oxymetazoline 0.05% nasal solution|DIETARY_SUPPLEMENT: Bovril|DRUG: Acetazolamide|DRUG: Rivastigmine tartrate|DRUG: Carbidopa/levodopa|DEVICE: Inflatable abdominal binder|DEVICE: inflatable abdominal binder (sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Effects of Acupuncture on Pain and Quality of Life of People Affected With Chronic Widespread Pain.
Status: UNKNOWN
Conditions: Chronic Widespread Pain
Interventions: DEVICE: Acupuncture|DEVICE: Sham Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Splint Users' Satisfaction and Functional Status With Custom Finger Splints
Status: RECRUITING
Conditions: Hypermobility of Interphalangeal Joints|Swan-Neck Deformity
Interventions: DEVICE: 3D-Printed Finger Splints|DEVICE: Conventional Finger Splints
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: COMPARISON OF CORNEAL MEASUREMENTS IN NORMAL AND KERATOCONUS EYES USING ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY AND PENTACAM HR TOPOGRAPHER
Status: COMPLETED
Conditions: The Reliability of Corneal Topographic Measurements of Keratoconus Eyes
Interventions: DIAGNOSTIC_TEST: corneal topography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Does a Drain Tube Influence the Postoperative Epidural Haematoma for Lumbar Biportal Endoscopic Surgery?
Status: COMPLETED
Conditions: Drain Tube Influence the Postoperative Epidural Haematoma
Interventions: PROCEDURE: two level lumbar decompression with BESS procedure received one drain.|PROCEDURE: two level lumbar decompression with BESS procedure received two drain.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Research Study Looking at Blood Sugar Control in People With Type 2 Diabetes Previously Treated With Premix Insulin and Initiating Treatment With Insulin Degludec/Liraglutide (IDegLira) in Local Clinical Practice in Croatia
Status: WITHDRAWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: IDegLira
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: mFOLFOXIRI Versus mFOLFOX6 as Adjuvant Chemotherapy for Locally Advanced Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: mFOLFOXIRI adjuvant chemotherapy|DRUG: mFOLFOX6 adjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of GNR-086 (Canakinumab Biosimilar) and Ilaris® in Patients With Adult Still's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Still's Disease Adult Onset
Interventions: BIOLOGICAL: GNR-086|BIOLOGICAL: Ilaris®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Benefit of Preoperative Supplemental Vitamin D in Patients Undergoing Major Surgical Procedures.
Status: WITHDRAWN
Conditions: Vitamin d Deficiency
Interventions: PROCEDURE: Blood draw pre-operatively|PROCEDURE: Blood draw post-operative Day 1|PROCEDURE: Blood draw post-operative Day 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Zevalin-beam for Aggressive Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: ibritumomab tiuxetan|PROCEDURE: BEAM chemotherapy and autologous stem-cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulsatile Insulin Infusion Therapy in Patients With Type 1 and Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Diabetes Mellitus, Type 1
Interventions: DRUG: 3 hours humulin R 100 IU/mL PIT|DRUG: 2 hours humulin R 100 IU/mL PIT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Feeding Ability of Preterm Infants With Breastfeeding Support System
Status: RECRUITING
Conditions: Nutrition Disorder, Infant|Nutrition
Interventions: OTHER: Supplemental Feeding System Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Positive Effects of Daily Consumption of Bread Enriched With Hydroxytyrosol on the Results of a 12-week Dietary Intervention on Subjects With Type 2 Diabetes Mellitus and Overweight/ Obesity
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Obesity
Interventions: OTHER: Wheat bread enriched with hydroxytyrosol|OTHER: Wheat bread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Lung Atelectasis During Apneic Oxygenation Using THRIVE in Adults During Laryngeal Surgery.
Status: COMPLETED
Conditions: Anesthesia
Interventions: DEVICE: THRIVE|DEVICE: Endotracheal intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Treating Early Childhood Caries Under Local or General Anesthesia Have Varying Effects on OHRQoL
Status: COMPLETED
Conditions: Oral Health Related Quality of Life OHRQoL
Interventions: PROCEDURE: Dental treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Dose Study of SHR0410 in Healthy Male Participants
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: 0.5μg/kg SHR0410|DRUG: 1μg/kg SHR0410|DRUG: 2μg/kg SHR0410|DRUG: 5μg/kg SHR0410|DRUG: 10μg/kg SHR0410|DRUG: 20μg/kg SHR0410
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Patient-Partnered, Pan-Canadian, Comparative Effectiveness Evaluation of an Acute Pediatric Mental Health and Addiction Care Bundle
Status: RECRUITING
Conditions: Mental Health|Mental Disorders|Pediatrics|Emergency Psychiatric
Interventions: OTHER: Health Services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Peri-neural Electrical Dry Needling Migraine Treatment Study
Status: UNKNOWN
Conditions: Migraine Headache
Interventions: PROCEDURE: Perineural electrical dry needling|PROCEDURE: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety & Effectiveness of Duodenal Mucosal Resurfacing (DMR) Using the Revita™ System in Treatment of Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DEVICE: Duodenal Mucosal Resurfacing (DMR)|DEVICE: Duodenal Mucosal Resurfacing Sham (Sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of SM04755 Following Topical Administration to Healthy Subjects
Status: COMPLETED
Conditions: Tendinopathy
Interventions: DRUG: SM04755|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Fitness and Strength in Postoperative Cardiac Patients Undergoing Exercise Therapy: Biological and Functional Mechanisms of Recovery
Status: COMPLETED
Conditions: Cardiorespiratory; Insufficiency, Due to A Procedure, Long-Term, Cardiac Surgery
Interventions: BEHAVIORAL: Cardiac Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vitamin B6 Supplementation and Mood States in College Women Taking Oral Contraceptives
Status: COMPLETED
Conditions: Depression
Interventions: DIETARY_SUPPLEMENT: vitamin B6|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Efficacy, Safety and Tolerability of PDNO Infusion in COVID-19 Patients With Acute Pulmonary Hypertension
Status: WITHDRAWN
Conditions: Pulmonary Hypertension|COVID-19
Interventions: DRUG: Sodium chloride (placebo)|DRUG: PDNO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Non-cystic Fibrosis Bronchiectasis
Status: RECRUITING
Conditions: Bronchiectasis
Interventions: DRUG: Itepekimab (SAR440340)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Motor Network in Parkinson's Disease and Dystonia: Mechanisms of Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson Disease|Dystonia
Interventions: DEVICE: Summit RC+S for Motor|DIAGNOSTIC_TEST: 8-week pilot trial of Closed-loop vs. Open-loop Stimulation|DEVICE: Summit RC+S for Sleep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reversal of Dabigatran With Prothrombin Complex Concentrate
Status: UNKNOWN
Conditions: Drug Action Reversal
Interventions: DRUG: Beriplex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Therapeutic Effects of Trigger Point Injection and Twin Nerve Block in Chronic Myofascial Pain Patients
Status: COMPLETED
Conditions: Myofascial Pain - Dysfunction Syndrome of TMJ|Trigger Point Pain, Myofascial|Nerve Block
Interventions: OTHER: Injection of either twin block or trigger point injection.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Repeated tDCS Sessions on Cognitive Improvement in Patients With Disorders of Consciousness
Status: COMPLETED
Conditions: Disorders of Consciousness|Severe Brain Injury|Post-comatose Non-communicative Patients
Interventions: DEVICE: transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Inactivated, Split-Virion Influenza Vaccine Compared With Standard Fluzone Vaccine in Infants and Children
Status: COMPLETED
Conditions: Orthomyxoviridae Infection|Influenza|Myxovirus Infection
Interventions: BIOLOGICAL: Split, Inactivated, Trivalent Influenza Vaccine|BIOLOGICAL: Split, Inactivated, Trivalent Influenza Vaccine|BIOLOGICAL: Split, Inactivated, Trivalent Influenza Vaccine ( Fluzone® 2006/2007 Formulation)|BIOLOGICAL: Split, Inactivated, Trivalent Influenza Vaccine ( Fluzone® 2006/2007 Formulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effects of Transcranial Direct Current Stimulation on Executive Function in People With Mild to Moderate Dementia
Status: UNKNOWN
Conditions: Dementia|Executive Function|Transcranial Direct Current Stimulation
Interventions: DEVICE: transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b/2 Study of IPI-145 Plus FCR in Previously Untreated, Younger Patients With CLL
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: IPI-145|DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study to Compare Cypher Versus Cypher Select in Treating Cornary Artery Lesions.
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Cypher Select|DEVICE: Cypher
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Practicality of Intermittent Fasting and Its Effect on Markers of Aging and Oxidative Stress
Status: COMPLETED
Conditions: Aging|Metabolism
Interventions: OTHER: Intermittent Fasting|DIETARY_SUPPLEMENT: 400 IU Vitamin E|DIETARY_SUPPLEMENT: 1000 mg Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Brain Oxygenation and Hemodynamics During Sleep in Obstructive Sleep Apnea Sufferers
Status: COMPLETED
Conditions: Obstructive Sleep Apnea Syndrome
Interventions: DEVICE: OxiplexTS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC