pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Neuromodulation vs. Electrolysis in Plantar Fasciitis
Status: COMPLETED
Conditions: Plantar Fascitis
Interventions: OTHER: Percutaneous neuromodulation in tibial nerve|OTHER: Percutaneous electrolysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Adaptations to High-fat Diet
Status: NOT_YET_RECRUITING
Conditions: Adiposity|Insulin Sensitivity|Impaired Glucose Tolerance|Metabolic Disturbance
Interventions: BEHAVIORAL: Hypercaloric, High Fat Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Erlotinib and Sirolimus for the Treatment of Metastatic Renal Cell Carcinoma
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Erlotinib hydrochloride|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Randomized Study Evaluating the Biological and Clinical Effects of the Combination of Palbociclib With Letrozole as Neoadjuvant Therapy in Post-Menopausal Women With Estrogen-Receptor Positive Primary Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Breast Carcinoma|Breast Tumors
Interventions: DRUG: Letrozole|DRUG: palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ahmed Valve Implantation Coated With Poly Lactic -Co-glycolic Acid (PLGA) Saturated With Mitomycin-C in the Management of Adult Onset Glaucoma in Sturge Weber Syndrome
Status: UNKNOWN
Conditions: Glaucoma
Interventions: PROCEDURE: Ahmed Valve
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of Chinese Medical Treatment on Leucopenia After Chemotherapy in Breast Cancer Patients
Status: UNKNOWN
Conditions: Leucopenia|Breast Cancer
Interventions: DRUG: Chinese medical treatment-LCH1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First-in-Human Trial of Single Ascending Dose, Multiple Ascending Dose and Malaria Challenge Model in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: M5717|DRUG: Placebo|DRUG: M5717
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: IPRP Repeated Transcranial Magnetic Stimulation (rTMS)
Status: RECRUITING
Conditions: Chronic Pain
Interventions: DEVICE: Repeated Transcranial Magnetic Stimulation (rTMS)|OTHER: Intensive Pain Rehabilitation Program (IPRP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Empagliflozin (BI 10773) in Patients With Type 2 Diabetes and Renal Impairment
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Renal Insufficiency
Interventions: DRUG: BI 10773|DRUG: Placebo|DRUG: Placebo|DRUG: BI 10773|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: EMPRA (EMPagliflozin and RAs in Kidney Disease)
Status: COMPLETED
Conditions: Diabetic Kidney Disease|Diabetes Mellitus, Type 2|Chronic Kidney Disease stage3|Chronic Kidney Disease stage4
Interventions: DRUG: Empagliflozin 10 MG [Jardiance]|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Letrozole and Goserelin or Leuprolide in Treating Premenopausal Estrogen Receptor-Positive Patients With Stage IV Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: goserelin|DRUG: letrozole|DRUG: leuprolide acetate|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prebiotics and the Management of Hyperuricemia
Status: RECRUITING
Conditions: Subjects With Hyperuricemia
Interventions: DIETARY_SUPPLEMENT: araboxylan|DIETARY_SUPPLEMENT: inulin|DIETARY_SUPPLEMENT: inulin and araboxylan|DIETARY_SUPPLEMENT: placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 1 Study to Evaluate Safety & Immunogenicity of rVSV-Nipah Virus Vaccine Candidate PHV02 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Nipah Virus Infection
Interventions: BIOLOGICAL: PHV02|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acoustic Cardiographic Assessment of Heart Function in Comparison to Doppler-echocardiography
Status: COMPLETED
Conditions: Heart Failure, Congestive|Antineoplastic Agents
Interventions: DEVICE: Doppler-echocardiography and acoustic cardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neurostimulation In Adult Survivors of Childhood Acute Lymphoblastic Leukemia (ALL)
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DEVICE: Active tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Group Motivational Interviewing and In-Home-Messaging-Devices for Dually Diagnosed Veterans
Status: COMPLETED
Conditions: Alcohol Dependence|Dual Diagnosis|Drug Dependence
Interventions: BEHAVIORAL: Arm 1 GMI|BEHAVIORAL: Arm 2 IHMD|BEHAVIORAL: Arm 3 TCC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sugammadex vs Neostigmine Reversal in Pediatric Appendectomy
Status: RECRUITING
Conditions: Appendicitis|Surgery
Interventions: DRUG: Sugammadex|DRUG: Neostigmine/Glycopyrrolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Multimodal Prehabilitation for Surgery in the Elderly: A Randomised, Prospective, Multicenter, Multidisciplinary Trial
Status: RECRUITING
Conditions: Frail Elderly Syndrome|Major Surgery
Interventions: PROCEDURE: Multimodal Prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Response to Rhinovirus Challenge
Status: COMPLETED
Conditions: Asthma|Allergic Rhinitis
Interventions: BIOLOGICAL: Rhinovirus (GMP RV16 HRV-16)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy of Olanzapine Monotherapy for Treatment Bipolar Ⅰ Depression
Status: COMPLETED
Conditions: Bipolar Disorder|Depression, Bipolar
Interventions: DRUG: olanzapine|DRUG: Starch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Endometrial Carcinoma|Advanced Head and Neck Squamous Cell Carcinoma|Advanced Malignant Solid Neoplasm|Advanced Melanoma|Advanced Ovarian Clear Cell Adenocarcinoma|Chondrosarcoma|Clinical Stage III Cutaneous Melanoma AJCC v8|Clinical Stage IV Cutaneous Melanoma AJCC v8|Pathologic Stage III Cutaneous Melanoma AJCC v8|Pathologic Stage IIIA Cutaneous Melanoma AJCC v8|Pathologic Stage IIIB Cutaneous Melanoma AJCC v8|Pathologic Stage IIIC Cutaneous Melanoma AJCC v8|Pathologic Stage IIID Cutaneous Melanoma AJCC v8|Pathologic Stage IV Cutaneous Melanoma AJCC v8|Recurrent Ovarian High Grade Serous Adenocarcinoma|Refractory Endometrial Carcinoma|Refractory Head and Neck Squamous Cell Carcinoma|Refractory Melanoma|Refractory Ovarian Clear Cell Adenocarcinoma|Refractory Ovarian High Grade Serous Adenocarcinoma|Stage III Ovarian Cancer AJCC v8|Stage III Uterine Corpus Cancer AJCC v8|Stage IIIA Ovarian Cancer AJCC v8|Stage IIIA Uterine Corpus Cancer AJCC v8|Stage IIIA1 Ovarian Cancer AJCC v8|Stage IIIA2 Ovarian Cancer AJCC v8|Stage IIIB Ovarian Cancer AJCC v8|Stage IIIB Uterine Corpus Cancer AJCC v8|Stage IIIC Ovarian Cancer AJCC v8|Stage IIIC Uterine Corpus Cancer AJCC v8|Stage IIIC1 Uterine Corpus Cancer AJCC v8|Stage IIIC2 Uterine Corpus Cancer AJCC v8|Stage IV Ovarian Cancer AJCC v8|Stage IV Uterine Corpus Cancer AJCC v8|Stage IVA Ovarian Cancer AJCC v8|Stage IVA Uterine Corpus Cancer AJCC v8|Stage IVB Ovarian Cancer AJCC v8|Stage IVB Uterine Corpus Cancer AJCC v8
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Glutaminase-1 Inhibitor IACS-6274|DRUG: Paclitaxel|DRUG: Capivasertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Broccoli Sprout Intervention in Qidong, P.R. China
Status: COMPLETED
Conditions: Environmental Carcinogenesis
Interventions: DRUG: Broccoli Sprout Extract Beverage|DRUG: placebo beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Comparison Colon Capsule Endoscopy vs Optical Colonoscopy for Colorectal Cancer Screening in Familiar-Risk Population
Status: COMPLETED
Conditions: Colorectal Cancer, Genetics of
Interventions: PROCEDURE: COLON CAPSULE ENDOSCOPY ADHERENCE|PROCEDURE: OPTICAL COLONOSCOPY ADHERENCE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: RE001 T Cell Injection for the Treatment of KRAS G12V Mutated Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: KRAS G12V|T Cell Therapy
Interventions: BIOLOGICAL: RE001 T cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-Workout on Exercise Performance and Cognition
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Master Performance Blend Dose 1|DIETARY_SUPPLEMENT: Master Performance Blend Dose 2|DIETARY_SUPPLEMENT: Performance Energy Blend|DIETARY_SUPPLEMENT: Energy Blend|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: MM-398 and Ramucirumab in Treating Patients With Gastric Cancer or Gastroesophageal Junction Adenocarcinoma
Status: WITHDRAWN
Conditions: Locally Advanced Unresectable Gastric Adenocarcinoma|Metastatic Gastroesophageal Junction Adenocarcinoma|Metastatic Unresectable Gastric Adenocarcinoma|Unresectable Gastroesophageal Junction Adenocarcinoma|Gastric Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Liposomal Irinotecan|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|BIOLOGICAL: Ramucirumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Neurokinin-1 Receptor Antagonist for the Treatment of Pruritus in Patients With Epidermolysis Bullosa
Status: COMPLETED
Conditions: Epidermolysis Bullosa
Interventions: DRUG: Serlopitant Tablet|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Controlled Sedoanalgesia in External DCR Surgery
Status: COMPLETED
Conditions: Dacryocystorhinostomy|Sedation|General Anesthesia
Interventions: PROCEDURE: Controlled sedoanalgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Preventing Cancer Recurrence in Patients With Non-Metastatic, Node Positive, HER2 Negative Breast Cancer That is in Remission
Status: ACTIVE_NOT_RECRUITING
Conditions: HER2/Neu Negative|No Evidence of Disease|One or More Positive Axillary Nodes|Stage IB Breast Cancer|Stage II Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage III Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: pUMVC3-IGFBP2-HER2-IGF1R Plasmid DNA Vaccine|BIOLOGICAL: Sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Multiple Doses of BI 187004 on the Single-dose Pharmacokinetics of Repaglinide and Bupropion in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: repaglinide|DRUG: BI 187004 tablet|DRUG: bupropion extended release tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study of Re-Irradiation in Recurrent Glioblastoma
Status: WITHDRAWN
Conditions: Recurrent Glioblastoma
Interventions: DRUG: TMZ plus concurrent re-irradiation|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Comparison of BLI4700 Bowel Prep Versus an FDA-approved Comparator in Adults Prior to Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: BLI4700|DRUG: Polyethylene glycol bowel preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bicarbonate Administration in CKD
Status: COMPLETED
Conditions: Chronic Kidney Disease|Metabolic Acidosis
Interventions: DRUG: Sodium bicarbonate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuro-psychosocial Teleassistance for Neuromuscular Diseases
Status: COMPLETED
Conditions: Social Competence|Self Esteem|Quality of Life|Social Skills|Neuromuscular Diseases
Interventions: BEHAVIORAL: Neuro-psychosocial teleassistance program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of High Dose of Vitamin B6 With Magnesium in Children With Autism Spectrum Disorder
Status: COMPLETED
Conditions: ASD
Interventions: DRUG: Vitamin B 6 with Magnesium|DRUG: placebo of vitamin B6 and magnesium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IOP Fluctuations in Primary Open Angle Glaucoma Patients Before and After Deep Sclerectomy With Collagen Implant
Status: TERMINATED
Conditions: Primary Open Angle Glaucoma
Interventions: DEVICE: SENSIMED Triggerfish®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Tipifarnib and Combination Chemotherapy in Treating Patients With Stage II or Stage III Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Male Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: DRUG: tipifarnib|DRUG: paclitaxel|DRUG: doxorubicin|DRUG: cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Dosing Study of BAX 513 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: Fucoidan (extract of Laminaria japonica)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy Testing of Djulis-Buckwheat Drink on Cardiovascular Protection
Status: WITHDRAWN
Conditions: Prehypertension|Hypertension Stage 1
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Djulis-Buckwheat|DIETARY_SUPPLEMENT: Buckwheat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Role of Poisoning Severity Score, Serum Procalcitonin and C-reactive Protein in Acute Hydrocarbon Intoxicated Cases Admitted to the Poison Control Center Ain Shams University Hospitals
Status: NOT_YET_RECRUITING
Conditions: Acute Hydrocarbon Toxicity
Interventions: DIAGNOSTIC_TEST: serum procalcitonin|DIAGNOSTIC_TEST: C-reactive protein
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prevalence of Anal High-risk Human Papilloma Virus Infection and Abnormal Anal Cytology in Men Who Have Sex With Men Using Pre Exposure Prophylaxis
Status: ACTIVE_NOT_RECRUITING
Conditions: Human Papilloma Virus
Interventions: OTHER: anal sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: PET TDM FDG-Choline as a Decision-making Tool for Routine Care on the Liver Transplant List for HCC
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Liver Transplant
Interventions: RADIATION: PET TDM FDG-Choline
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Cutaneous Leishmaniasis With a Combination of Miltefosine and Antimony
Status: TERMINATED
Conditions: Cutaneous Leishmaniasis
Interventions: DRUG: Miltefosine and antimony|DRUG: Miltefosine alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacity of Idelalisib and Obinutuzumab in Patient With Relapsed Refractory Waldenstrom's Macroglobulinemia
Status: COMPLETED
Conditions: Waldenstrom Macroglobulinemia
Interventions: DRUG: Obinutuzumab|DRUG: Idelalisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Benralizumab on Exercise-induced Bronchoconstriction
Status: UNKNOWN
Conditions: Asthma, Exercise-Induced
Interventions: DRUG: Benralizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Fully Human BCMA CAR-T (CT103A) in Patients With Newly Diagnosed High-risk Multiple Myeloma (FUMANBA-2)
Status: NOT_YET_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Fully human BCMA chimeric antigen receptor autologous T cell injection (CT103A)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SAFEstart Feeding Intolerance Study Phase II
Status: COMPLETED
Conditions: Feeding Intolerance|Abdominal Distention|Gastric Residual|Emesis and Diarrhea|Blood in Stool
Interventions: DRUG: SAFEstart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Proprioceptive Thumb Exercises Program in Patients With Carpometacarpal Joint Osteoarthritis
Status: COMPLETED
Conditions: Thumb Osteoarthritis
Interventions: OTHER: Proprioceptive thumb exercises.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bupivacaine 0.125% Versus Bupivacaine 0.25% in Superficial Cervical Plexus Block for Tympanomastoid Surgeries in Adults
Status: RECRUITING
Conditions: Surgical Field|Acute Postoperative Pain
Interventions: DRUG: bupivacaine 0.25%|DRUG: bupivacaine 0.125%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer
Status: RECRUITING
Conditions: Locally Advanced Rectal Carcinoma|Rectal Adenocarcinoma|Stage II Rectal Cancer AJCC v8|Stage IIA Rectal Cancer AJCC v8|Stage IIB Rectal Cancer AJCC v8|Stage IIC Rectal Cancer AJCC v8|Stage III Rectal Cancer AJCC v8|Stage IIIA Rectal Cancer AJCC v8|Stage IIIB Rectal Cancer AJCC v8|Stage IIIC Rectal Cancer AJCC v8
Interventions: DRUG: Capecitabine|DRUG: Fluorouracil|RADIATION: Intensity-Modulated Radiation Therapy|DRUG: Leucovorin|DRUG: Oxaliplatin|OTHER: Quality-of-Life Assessment|BEHAVIORAL: Surveillance|PROCEDURE: Total Mesorectal Excision
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrical Coupling Information From The RHYTHMIA HDx Mapping System and DIRECTSENSE Technology In The Treatment of Paroxysmal Atrial Fibrillation (LOCALIZE CF)
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: Ablation procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors.
Status: RECRUITING
Conditions: CNS Tumors|Meningioma|Esthesioneuroblastoma|Hemangioblastoma|Medulloblastoma|Paraganglioma|Pituitary Adenoma
Interventions: DIAGNOSTIC_TEST: Ga68-DOTATATE-PET/MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Efficacy of Prolonged Antibiotic Therapy for the Prevention of Relapsing Peritonitis in Peritoneal Dialysis Patients With High Dialysis Effluent Bacterial DNA Fragment Levels
Status: COMPLETED
Conditions: Peritoneal Dialysis
Interventions: DRUG: Extended antibiotics (cefazolin or ceftazidime)|DRUG: Usual antibiotics (cefazolin or ceftazidime)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Noninvasive Positive Pressure Ventilation for Early Extubation of Acute Hypoxemic Respiratory Failure
Status: WITHDRAWN
Conditions: Acute Hypoxemic Respiratory Failure
Interventions: DEVICE: noninvasive positive pressure ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Nicotine Patches in Reducing Hand-Foot Syndrome in Patients Who Are Receiving Capecitabine For Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer|Chemotherapeutic Agent Toxicity|Palmar-plantar Erythrodysesthesia
Interventions: DRUG: Nicotine patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: iCAGES-guided Precision Therapy for Cancers in Contrast to Standard Care or IHC-guided Theray
Status: RECRUITING
Conditions: Lung Cancer|Gene Abnormality|Gene Product Sequence Variation|Cancer
Interventions: DRUG: inhibitors, ADC drugs such as tarceva, capmatinib, padcev et al for A/C group.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prevention, Management and Rehabilitation of Knee Osteoarthritis at the Workplace
Status: NOT_YET_RECRUITING
Conditions: Knee Pain Chronic|Knee Osteoarthritis|Knee Discomfort
Interventions: BEHAVIORAL: Blood flow restriction (BFR)|BEHAVIORAL: Usual care (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease
Status: COMPLETED
Conditions: Primary Hypertension
Interventions: DRUG: spironolactone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Physiologic Mixed Meal Tolerance
Status: WITHDRAWN
Conditions: Insulin|Glucose|Healthy Volunteers|Women|Pregnancy
Interventions: DRUG: Kisspeptin-10|OTHER: mixed meal tolerance test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A(H7N9) VLP Antigen Dose Ranging Study With Adjuvant 1
Status: COMPLETED
Conditions: Avian Influenza
Interventions: BIOLOGICAL: Monovalent Avian Influenza VLP (H7N9)|BIOLOGICAL: Adjuvant 1|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An All-Oral Combination of Capecitabine and Cyclophosphamide in Patients With Metastatic Breast Cancer (MBC)
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: capecitabine and cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Efruxifermin in Subjects With Histologically Confirmed Nonalcoholic Steatohepatitis (NASH)
Status: COMPLETED
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: DRUG: EFX|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postprandial Glucose, Insulin Response to Meal Sequence Among Healthy UAE Adults
Status: COMPLETED
Conditions: Postprandial Hyperglycemia
Interventions: OTHER: vegetable and protein first followed by carbohydrates (VPF) meal sequence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Concurrent Radiochemotherapy Plus Anlotinib for Locally Advanced Cervical Cancer
Status: RECRUITING
Conditions: Uterine Cervical Neoplasms|Chemoradiotherapy|Angiogenesis
Interventions: DRUG: Hydrochloride anlotinib|DRUG: cis Platinum/carboplatin|RADIATION: External beam radiotherapy and brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Heparin for Hospitalised Patients With Coronavirus Disease 2019 (COVID-19)
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: Unfractionated Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sexual Penetration Pain in Postmenopausal Women: A Topical Botanical Drug Treatment
Status: TERMINATED
Conditions: Sexual Pain Disorders|Postmenopausal Symptoms|Vulvovaginal Atrophy|Female Sexual Dysfunction|Dyspareunia|Vulvodynia|Vestibulodynia|Arousal Disorders, Sexual|Genito-Pelvic Pain/Penetration Disorder|Female Sexual Arousal Disorder
Interventions: DRUG: 5% sinecatechins ointment|DRUG: Placebo|DRUG: 10% sinecatechins ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tafasitamab, Lenalidomide and Venetoclax for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma
Status: RECRUITING
Conditions: Recurrent Mantle Cell Lymphoma|Refractory Mantle Cell Lymphoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Computed Tomography|DRUG: Lenalidomide|PROCEDURE: Lumbar Puncture|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|BIOLOGICAL: Tafasitamab|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Gabapentin in Vulvodynia: Biological Correlates of Response
Status: COMPLETED
Conditions: Vulvodynia
Interventions: DRUG: Placebo oral capsule|DRUG: Gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Dose Putative Cognitive Enhancer VU319
Status: WITHDRAWN
Conditions: Cognitive Impairment
Interventions: DRUG: Dose Escalation of VU319|DRUG: Dose Escalation of Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of the OxyAqua Daily Disposable Silicone Hydrogel Soft Contact Lens
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: OxyAqua|DEVICE: Si-Hy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ETE Interventions in the Dental Setting
Status: RECRUITING
Conditions: HIV Infections
Interventions: OTHER: Care Navigator|OTHER: Health Information Supported Ending the HIV Epidemic (ETE) Activities in Dental Setting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Temsirolimus Alone or Paired With Dexamethasone Delivered to the Adventitia to eNhance Clinical Efficacy After Femoropopliteal Revascularization
Status: TERMINATED
Conditions: Peripheral Arterial Disease
Interventions: DRUG: Temsirolimus|DRUG: Temsirolimus and dexamethasone sodium phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SynerFuse Spinal Fusion and Neuromodulation Proof of Concept Study
Status: RECRUITING
Conditions: Spinal Fusion|Radiculopathy Lumbar|Chronic Pain
Interventions: DEVICE: DRG Neurostimulation with Spinal Fusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Stabilizer Assisted RVC With rtPA for CRVO
Status: WITHDRAWN
Conditions: Central Retinal Vein Occlusion
Interventions: PROCEDURE: Vitrectomy with retinal vein cannulation and intravenous rtPA (Actilyse) infusion up to 1mg.|DRUG: Intravenous Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CPT-11/Cisplatin and Celecoxib With Radiation Therapy for Patients With Unresectable Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Celecoxib|DRUG: Cisplatin|DRUG: CPT-11|RADIATION: Concurrent Thoracic Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RNS System RESPONSE Study
Status: RECRUITING
Conditions: Epilepsy|Partial Seizure|Neurostimulator; Complications|Drug Resistant Epilepsy|Focal Epilepsy
Interventions: DEVICE: RNS System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block in Uniportal VATS
Status: UNKNOWN
Conditions: Thoracic Surgery|Uniportal Video Assisted Thoracic Surgery (U-VATS)|Lung Resections|Post-Operative Pain, Chronic|Acute Pain|Post-operative Complications|Locoregional Anesthesia
Interventions: PROCEDURE: c-ESPB|PROCEDURE: c-SAPB|PROCEDURE: ICNB
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Performance of the GYNECARE PROLIFT + M* Pelvic Floor Repair System as a Device for Pelvic Organ Prolapse
Status: COMPLETED
Conditions: Cystocele|Rectocele|Enterocele
Interventions: DEVICE: GYNECARE PROLIFT+M* Pelvic Floor Repair System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cardio-Renal Registry
Status: NOT_YET_RECRUITING
Conditions: End Stage Renal Disease|Cardio-Renal Syndrome|Myocardial Infarction|Cerebrovascular Accident|Percutaneous Coronary Intervention|Dialysis
Interventions: OTHER: Observation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Substance P as a Biomarker to Evaluate the Reduction of Multiple Immunization Pain
Status: COMPLETED
Conditions: Immunisation Anxiety Related Reaction|Pain, Acute
Interventions: DIETARY_SUPPLEMENT: Sucrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pivmecillinam With Amoxicillin/Clavulanic Acid for Step Down Oral Therapy in ESBL UTIs
Status: RECRUITING
Conditions: Urinary Tract Infections|Bacteremia|Antibiotic Resistant Infection
Interventions: DRUG: Pivmecillinam and amoxicillin/clavulanic acid|DRUG: Standard treatment, ciprofloxacin, trimethoprim/sulfamethoxazole or ertapenem depending on susceptibility
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Fenofibrate Added on to Atorvastatin Compared With Atorvastatin
Status: UNKNOWN
Conditions: Mixed Hyperlipidemia
Interventions: DRUG: Atorvastatin 20mg|DRUG: Fenofibrate 160mg|OTHER: Placebo (Fenofibrate 160 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Soymilk on Liver Disease Severity of Children With Non-alcoholic Fatty Liver Disease (NAFLD)
Status: RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: DRUG: Standard Soy Milk|DRUG: 2% Fat Cow's Milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Double Blind Randomised Placebo-controlled Trial to Assess the Role of Iron Repletion in Glucose Homeostasis.
Status: TERMINATED
Conditions: Iron-deficiency|Iron Toxicity|Glucose Metabolism Disorders (Including Diabetes Mellitus)|Metabolic Side Effects of Drugs|Metabolic Disorder, Glucose|Safety Issues
Interventions: DRUG: Ferric Carboxymaltose|DRUG: 0.9% sodium chloride solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Duration and Efficacy of Azstarys on Adult ADHD Symptoms and Executive Function in Early Evening
Status: RECRUITING
Conditions: Adult Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Serdexmethylphenidate/dexmethylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cross-cultural Adaptation, Reliability and Validity of the Turkish Version of the Headache Impact Questionnaire
Status: UNKNOWN
Conditions: Headache|Headache Disorders|Headache, Migraine|Headache, Tension|Headaches Chronic|Headaches Muscular
Interventions: OTHER: Survey study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: tAN for PTSD and OUD in Buprenorphine Therapy
Status: RECRUITING
Conditions: Posttraumatic Stress Disorder|Opioid Use Disorder
Interventions: DEVICE: Sparrow Ascent tAN|DEVICE: Sparrow Ascent Active Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sodium-glucose Co Transporter 2 (sGLT2) Inhibitor and Endogenous Ketone Production
Status: COMPLETED
Conditions: Empaglifozin|Physiological Effects of Drugs|Hypoglycemic Agents|Sodium-Glucose Transporter 2 Inhibitors
Interventions: DRUG: empagliflozin (Jardiance) 25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Chronic Asthma Study in 2- to 5-Year-Old Patients (MK0476-072 )
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: montelukast sodium|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of CAR-T Cells Targeting Both BCMA and GPRC5D in Treatment of Relapsed or Refractory Multiple Myeloma
Status: NOT_YET_RECRUITING
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: BMCA and GPRC5D dual target CAR-T cells(OriC321)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab Combined With Chemotherapy in the Treatment of Primary Tracheal Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Neoplasms|Carcinoma, Squamous|Antineoplastic Agents
Interventions: DRUG: Nivolumab Injection [Opdivo]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MisOpRostol Effect on Second Trimester Abortion Blood Loss
Status: ENROLLING_BY_INVITATION
Conditions: Blood Loss, Surgical|Second Trimester Abortion
Interventions: DRUG: Misoprostol 400mcg buccal|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Niraparib in Combination With Cabozantinib (XL184) in Patients With Advanced Urothelial Cancer (NICARAGUA)
Status: COMPLETED
Conditions: Urothelial Cancer
Interventions: DRUG: Niraparib plus Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Pilot Study to Evaluate the Efficacy and Safety of Neoadjuvant Chemoradiotherapy With Capecitabine, . . .
Status: WITHDRAWN
Conditions: Pancreatic Cancer
Interventions: OTHER: Neoadjuvant capecitabine, panitumumab and radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Legume-enriched Meals Compared to Western Diet Meals on Postprandial Metabolism in Participants With Increased Cardiometabolic Risk
Status: RECRUITING
Conditions: Cardiovascular Diseases|Metabolic Syndrome
Interventions: OTHER: High Protein Planetary Health Diet|OTHER: Low Protein Planetary Health Diet|OTHER: High Protein Western Diet|OTHER: Low Protein Western Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Different Kinds of Ear Tubes
Status: UNKNOWN
Conditions: Recurrent Acute Otitis Media|Otitis Media With Effusion With Hearing Impairment
Interventions: DEVICE: Insertion of a specific type of ventilation tube through the tympanic membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Primary Care-Based Interventions to Reduce Alcohol Use Among HIV Patients
Status: COMPLETED
Conditions: HIV|Acquired Immunodeficiency Syndrome|Alcoholism|Alcoholic Intoxication|Substance-Related Disorders
Interventions: BEHAVIORAL: Motivational Interviewing|BEHAVIORAL: Email Feedback|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: CRAIL - Controlled Reperfusion of the Acutely Ischemic Limb
Status: TERMINATED
Conditions: Lower Extremity Ischemia
Interventions: PROCEDURE: conventional embolectomy/thrombectomy|PROCEDURE: embolectomy/thrombectomy with controlled reperfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Prolonging the Therapeutic Life Span of Artemisinin-based Combination Therapies (ACT) in Bagamoyo District, Tanzania"
Status: COMPLETED
Conditions: Malaria,Falciparum
Interventions: DRUG: Artemether-Lumefantrine Tab 20-120mg|DRUG: Primaquine Phosphate 0.25 mg/kg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Self-Compassion Intervention on Enhancing Self-Compassion and Psychological Well-Being of Children With Attention Deficit/Hyperactivity Disorder
Status: RECRUITING
Conditions: ADHD|Self-Compassion|Psychological Well-Being
Interventions: BEHAVIORAL: Self-Compassion Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Tranexamic Acid for Upper Gastrointestinal Bleeding
Status: UNKNOWN
Conditions: Acute Upper Gastrointestinal Hemorrhage
Interventions: DRUG: Early intravenous tranexamic acid administration|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postmenopausal Hormone Therapy in Unstable Angina
Status: COMPLETED
Conditions: Angina, Unstable|Cardiovascular Diseases|Coronary Disease|Heart Diseases|Postmenopause
Interventions: DRUG: estrogen replacement therapy|DRUG: estrogens|DRUG: progesterone|DRUG: hormone replacement therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Ipatasertib and Docetaxel in Metastatic NSCLC Patients Who Have Failed 1st Line Immunotherapy
Status: RECRUITING
Conditions: NSCLC Stage IV|NSCLC Stage IIIB
Interventions: DRUG: Ipatasertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nu-3 Topical Gel for Treatment of Diabetic Foot Ulcer
Status: TERMINATED
Conditions: Chronic Diabetic Foot Ulcers
Interventions: DRUG: 5% Bisphosphocin Topical Gel|DRUG: Placebo Topical Gel|DRUG: 10% Bisphosphocin Topical Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Effects of Macitentan on Exercise Capacity in Subjects With Eisenmenger Syndrome
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Macitentan 10 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Treatment Response Using Multiparametric MRI After Prostate Radiotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DEVICE: multi-parametric MRI(MP-MRI)|DEVICE: dynamic contrast-enhanced MRI (DCE)|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Combination Chemotherapy of SIRIOX as First- or Second-Line Chemotherapy for Pancreatic Cancer
Status: UNKNOWN
Conditions: Carcinoma, Pancreatic Ductal
Interventions: DRUG: S1|DRUG: Oxaliplatin|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Consumption of Nut Components on Cognitive Function, Intestinal Microbial Communities and Markers of Health
Status: COMPLETED
Conditions: Cognitive Function|Urinary Metabolites|Intestinal Microbiota
Interventions: OTHER: Nut components|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced Mouth Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: ethynyluracil|DRUG: fluorouracil|DRUG: hydroxyurea|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Improving Self-Management Skills Among People With Spinal Cord Injury
Status: UNKNOWN
Conditions: Spinal Cord Injuries|Self-Management|Mobile Application
Interventions: DEVICE: Mobile application ("app")
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acellular Dermal Matrix Allograft Versus Free Gingival Graft
Status: COMPLETED
Conditions: Gingiva Atrophy|Gingivitis
Interventions: PROCEDURE: Control|DEVICE: Acellular Dermal Matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Feasibility of Using Anesthesia and Suspended Ventilation to Immobilize Liver Tumors During Radiotherapy
Status: COMPLETED
Conditions: Liver Cancer
Interventions: PROCEDURE: image guidance with general anesthesia and suspended ventilation during treatment delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic or Preemptive Entecavir in Patients With Gastric Cancer Who Are Inactive Hepatitis B Carriers
Status: UNKNOWN
Conditions: Stomach Neoplasms
Interventions: DRUG: Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT