pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Minimally Invasive Versus Open Scarf Osteotomy for Hallux Valgus Correction: a Randomized Controlled Trial
Status: UNKNOWN
Conditions: Hallux Valgus and Bunion (Disorder)
Interventions: PROCEDURE: Open Scarf Osteotomy|PROCEDURE: Minimally invasive scarf Osteotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Global Multi-center Clinical Study of SARS-CoV-2 mRNA Vaccine for the Prevention of COVID-19
Status: RECRUITING
Conditions: SARS-CoV-2
Interventions: BIOLOGICAL: LVRNA009|OTHER: 0.9%NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: LAParoscopic Entry Technique in REnal Surgery
Status: UNKNOWN
Conditions: Kidney Diseases
Interventions: PROCEDURE: Open approach to port insertion|PROCEDURE: Closed approach to port insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Dipeptidyl Peptidase-4 (DPP-4) Inhibition on Hormonal Responses to Macronutrient Ingestion
Status: COMPLETED
Conditions: Healthy|Type 2 Diabetes
Interventions: DRUG: Sitagliptin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Improving Endometrial Cancer Assessment by Combining Genomic Profiling and Surgical Assessment
Status: RECRUITING
Conditions: Endometrial Cancer
Interventions: PROCEDURE: total hysterectomy with bilateral salpingo-oophorectomy, lymph node staging and comprehensive peritoneal staging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Proof of Concept Study to Evaluate the Effectiveness of Tysabri in Relapsing Remitting Multiple Sclerosis (RRMS) Patient Bladder Function
Status: COMPLETED
Conditions: Relapsing-Remitting Multiple Sclerosis
Interventions: DRUG: BG0002 (natalizumab)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of HCP1303 Capsules
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: HCP1303 capsule 5/0.2mg|DRUG: HCP1303 capsule 5/0.4mg|DRUG: HGP1201|DRUG: HCP1303 capsule 5/0.2mg placebo|DRUG: HCP1303 capsule 5/0.4mg placebo|DRUG: HGP1201 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Propofol for Pediatric Tracheal Intubation With Deep Anesthesia During Sevoflurane Induction
Status: COMPLETED
Conditions: Anesthesia Intubation Complication
Interventions: DRUG: propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Comparison Between Full Thickness and Partial Thickness Corneal Transplantation for Corneal Edema
Status: COMPLETED
Conditions: Fuchs Dystrophy|Corneal Edema
Interventions: PROCEDURE: Corneal transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Cancer Screening and Education in Hong Kong
Status: UNKNOWN
Conditions: Oral Cancer|Oral Leukoplakia|Oral Submucous Fibrosis|Proliferative Verrucous Leukoplakia|Oral Erythroplakia|Erosive Lichen Planus
Interventions: OTHER: No intervention utilised
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Two Implant Prosthetic Pathways
Status: COMPLETED
Conditions: Failure of Dental Prosthesis
Interventions: DEVICE: Anatomic e.max Abutment|DEVICE: CAD/CAM CARES Abutment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Light Intervention for Adaptation to Night Work
Status: COMPLETED
Conditions: Shift-Work Related Sleep Disturbance|Sleep Deprivation|Sleep
Interventions: DEVICE: LED-light, 1000 lux|DEVICE: LED-light, 100 lux|DEVICE: LED-light, 7000 K|DEVICE: LED-light, 2500 K|DEVICE: Blue LED-light|DEVICE: Red LED-light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Laser Puncture Versus Ultraviolet Radiation on Women With Polycystic Ovarian Syndrome
Status: RECRUITING
Conditions: Polycystic Ovary Syndrome
Interventions: DEVICE: aser puncture|DEVICE: ultraviolet radiatio|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicentre Trial to Compare Two Articulating Bearing Surfaces as Used in Cementless Primary Hip Arthroplasty
Status: TERMINATED
Conditions: Osteoarthritis
Interventions: DEVICE: Metal on ceramic articulation|DEVICE: Metal-on-Metal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Remote Preconditioning and Myocardial Protection
Status: COMPLETED
Conditions: Congenital Heart Disease
Interventions: DRUG: Sevoflurane plus remote ischemic preconditioning|DRUG: Total intravenous anesthesia plus remote ischemic preconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Open-Label Study of Sofusbuvir+Ribavirin With or Without Peginterferon Alfa-2a in Subjects With Chronic HCV Infection Who Participated in Prior Gilead HCV Studies
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: SOF|DRUG: RBV|DRUG: Peg-IFN
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beta Cell Imaging During and Shortly After the Honeymoon Phase of T1D
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 1 Diabetes Mellitus
Interventions: RADIATION: gallium-68-exendin injection followed by PET/CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Series of Study in Testing Efficacy of Pulmonary Rehabilitation Interventions in Lung Cancer Survivors
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BEHAVIORAL: Home rehabilitation exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Influence of Co-diagnosis of Chronic Fatigue Syndrome in Patients With Fibromyalgia.
Status: ACTIVE_NOT_RECRUITING
Conditions: Fibromyalgia|Chronic Fatigue Syndrome|Comorbidities and Coexisting Conditions
Interventions: BEHAVIORAL: Subjective quality of live|PROCEDURE: Blood extraction|BEHAVIORAL: Accelerometry|DIETARY_SUPPLEMENT: Synbiotic complement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Coaching Performance Driven Practice Change in the Context of Value Based Purchasing Under New York Medicaid
Status: RECRUITING
Conditions: Opioid-use Disorder|Substance Use Disorders
Interventions: BEHAVIORAL: Metrics-driven quality improvement (MDQI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Glutathione, Vitamin C and Cysteine in Children With Autism and Severe Behavior Problems
Status: COMPLETED
Conditions: Autism|Severe Behavior Disorder
Interventions: DRUG: placebo|DRUG: glutathione|DRUG: glutathione, vit C and NAC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Empirical Left Atrial Appendage Isolation on Long-term Procedure Outcome in Patients With Persistent or Long-standing Persistent Atrial Fibrillation Undergoing Catheter Ablation
Status: COMPLETED
Conditions: Persistent Atrial Fibrillation
Interventions: PROCEDURE: RFCA of PV and extra-PV triggers|PROCEDURE: LAA isolation along with the conventional ablation strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult ETP-ALL
Status: UNKNOWN
Conditions: Leukemia, Acute|Leukemia, T Cell|Leukemia, Lymphoblastic
Interventions: DRUG: Chidamide|DRUG: Dexamethasone|DRUG: vincristine|DRUG: Cyclophosphamide|DRUG: Idarubicin|DRUG: Pegaspargase|DRUG: Adriamycin|DRUG: Methotrexate|DRUG: 6-Mercaptopurine|DRUG: Etoposide|DRUG: Cytarabine|PROCEDURE: Bone marrow aspiration|PROCEDURE: Intrathecal injection|RADIATION: Radiation therapy|GENETIC: NGS|PROCEDURE: allogeneic hematopoietic stem cell transplantation|DIAGNOSTIC_TEST: Flow-MRD|DIAGNOSTIC_TEST: FISH|DIAGNOSTIC_TEST: Flow immunophenotyping|DIAGNOSTIC_TEST: Karyotyping
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogene MSCs Transplantation in Liver for Patients With Chronic Liver Diseases Through Portal Vein by Ultrasound Guiding
Status: UNKNOWN
Conditions: Allogene Transplantation|Chronic Liver Diseases Patients|Through Portal Vein by Ultrasound Guiding
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Web-based Versus Standard Information for Same Day Hysterectomy (WISH)
Status: NOT_YET_RECRUITING
Conditions: Hysterectomy|LAP
Interventions: OTHER: On-line, multi-media information on a specifically designed website for Same Day Discharge following Laparoscopic Hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Aromatherapy With Lavender Essential Oil in Patients With Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Aromatherapy|Randomized Controlled Trial|Multiple Sclerosis
Interventions: BEHAVIORAL: lavender oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Rebuilding Inter-limb Transfer in Cervical SCI
Status: RECRUITING
Conditions: Cervical Spinal Cord Injury
Interventions: DEVICE: PCMS + Contralateral Motor Training|DEVICE: PCMS + Rest|DEVICE: Sham PCMS + Contralateral Motor Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Application of UP for Transdiagnostic Treatment of Emotional Disorders for UHR for Psychosis Patients
Status: UNKNOWN
Conditions: Emotional Dysfunction|Psychosis
Interventions: BEHAVIORAL: Unified Protocol for Transdiagnostic Treatment of Emotional Disorders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Continuous Cold-Therapy on Postoperative Pain and Narcotics Use Following Spinal Fusion
Status: WITHDRAWN
Conditions: Radiculopathy|Central Spinal Stenosis|Foraminal Stenosis|Herniated Nucleus Pulposus|Degenerative Disc Disease|Isthmic Spondylolisthesis|Degenerative Spondylolisthesis
Interventions: DEVICE: Cold-Therapy System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Dolutegravir Plus 2 NRTIs, in Treatment-Naïve HIV-2 Infected Subjects
Status: COMPLETED
Conditions: HIV II Infection
Interventions: DRUG: Dolutegravir 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label, Pilot Protocol of Patients With Rheumatoid Arthritis Who Switch to Infliximab After Incomplete Response to Etanercept
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: infliximab, etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Bioavailability Study of Baclofen 20 mg Tablets in Healthy Male Volunteers / Fasting State
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Baclofen|DRUG: Baclofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tromsø Birch Rust Allergy Study. Allergy to Birch Rust, a Possible Explanation to Seasonal Airway Allergy During Autumn?
Status: UNKNOWN
Conditions: Hypersensitivity, Immediate|Allergy
Interventions: DIAGNOSTIC_TEST: MeDALL questionnaire for allergic diseases|DIAGNOSTIC_TEST: Registration of allergic symptoms|DIAGNOSTIC_TEST: Skin Prick Test|DIAGNOSTIC_TEST: Specific IgE in serum|DIAGNOSTIC_TEST: Nasal provocation test|DIAGNOSTIC_TEST: Basophil Activation Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: BCG Vaccination Effect on Latent Reservoir Size in Treated HIV-1 Infection:
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV-1-infection
Interventions: BIOLOGICAL: BCG Vaccine AJVaccines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Identification of Prognostic Biomarkers for Progression of Invasive Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Carcinoma, Squamous Cell|Carcinoma, Squamous|Squamous Cell Carcinoma|Lung Neoplasms|Cancer of Lung|Cancer of the Lung|Lung Cancer|Neoplasms, Lung|Neoplasms, Pulmonary|Pulmonary Cancer|Pulmonary Neoplasms
Interventions: GENETIC: DNA Extraction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multiple Sclerosis and Overactive Bladder Treatment
Status: UNKNOWN
Conditions: Neurogenic Bladder Dysfunction
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation|DEVICE: Transcutaneous Posterior Tibial Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Metastatic Melanoma That Has Not Responded to Previous Treatment
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: incomplete Freund's adjuvant|BIOLOGICAL: recombinant tyrosinase-related protein-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Open Label Study of BMS-582664 in Locally Advanced or Metastatic Hepatocellular Cancer
Status: COMPLETED
Conditions: Hepatocellular Carcinoma (HCC)
Interventions: DRUG: brivanib (active)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Technology Assisted Rehabilitation for Upper Limb Function in Myotonic Dystrophy Type 1
Status: COMPLETED
Conditions: Myotonic Dystrophy Type 1 (DM1)
Interventions: DEVICE: Tyromotion Amadeo and Armeo Senso
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DAISY Uterine Drain Device Evaluation
Status: RECRUITING
Conditions: Cesarean Section Complications|Post Partum Hemorrhage|Uterine Atony With Hemorrhage|Uterine Bleeding
Interventions: DEVICE: DAISY Uterine Drain
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: High Dose Sequential Therapy and Autologous Stem Cell Rescue for Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: PROCEDURE: high dose chemotherapy then autologous hematopoietic cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Facilitating Adaptive Expertise in Learning Computed Tomography
Status: COMPLETED
Conditions: Adaptive Expertise|Error Management Training|Learning
Interventions: OTHER: Error Management Training (Difficult)|OTHER: Error Management Training (Easy)|OTHER: Error Avoidance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fixed Combination for Lipid and Blood Pressure Control
Status: WITHDRAWN
Conditions: Arterial Hypertension|Dyslipidemias|Blood Pressure|Lipid Metabolism Disorders
Interventions: DRUG: Atorvastatin, Amlodipine, Perindopril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Deferasirox in Patients With Non-transfusion Dependent Thalassemia
Status: COMPLETED
Conditions: Non-transfusion Dependent Thalassemia
Interventions: DRUG: deferasirox
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Ranging Study Evaluating AVE2268 in Patients With Type 2 Diabetes Not Adequately Controlled by a Metformin Treatment
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: AVE2268
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Enhance Balance and Mobility in People With Type 2 Diabetic Peripheral Neuropathy
Status: TERMINATED
Conditions: Diabetes Complications|Diabetic Neuropathies
Interventions: OTHER: Muscle power|OTHER: balance perturbation|OTHER: aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phenylbutyrate/Genistein Duotherapy in Delta F508-Heterozygotes (for Cystic Fibrosis)
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DRUG: Sodium 4-Phenylbutyrate|DRUG: Genistein (Unconjugated Isoflavones 100)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Erythropoietin (EPO)+/- Filgrastim (G-CSF) vs. Supportive Therapy Alone for Patients With Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Anemia|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: Erythropoietin|BIOLOGICAL: Filgrastim|PROCEDURE: Transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neural Mobilization and Conventional Physical Therapy After Laminectomy
Status: COMPLETED
Conditions: Laminectomy
Interventions: OTHER: Neural mobilization combined with conventional physical therapy program|OTHER: Conventional physical therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Resorbable Glass Fiber Matrix in the Treatment of Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot Ulcer|Ulcer Foot|Diabetic Foot
Interventions: OTHER: Offloading|OTHER: Additional (outer) Dressing Application|OTHER: Mirragen Wound Matrix Dressing|OTHER: Fibracol Wound Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serial [18F]Thymidine (FLT)PET/CT as a Biomarker of Response in Pemetrexed Therapy for Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer|Starting Pemetrexed Based Therapy|Unresectable Cancer
Interventions: DRUG: Baseline 18F-thymidine (FLT) PET/CT|DRUG: Post-therapy 18F-thymidine (FLT) PET/CT to assess for pemetrexed induced tumor FLT "flare"|DRUG: Post-therapy 18F-thymidine (FLT) PET/CT to assess for pemetrexed induced changes in tumor proliferation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Nociceptive-Level (NOL) Intraoperative Guided Analgesia During Gynecological Laparoscopic Surgery Under General Anesthesia
Status: COMPLETED
Conditions: Gynecologic Laparoscopic Surgery|Hysterectomy|Oophorectomy
Interventions: DRUG: Intravenous Fentanyl guided by SoC+NOL|DRUG: Intravenous Fentanyl guided by SoC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ultrasound-Guided Peripheral Venous Access Using AccuCath
Status: COMPLETED
Conditions: Intravenous Access
Interventions: DEVICE: AccuCath catheter|DEVICE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Visual Function and Patient Satisfaction in Glaucoma or Ocular Hypertensive Patients Undergoing Simultaneous Cataract Surgery and i-Stent Implantation
Status: UNKNOWN
Conditions: Lenses, Intraocular|Glaucoma Filtration Implants
Interventions: DEVICE: I-Stent implantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Immunogenicity of MT-5625 in Healthy Adults, Toddlers and Infants
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: MT-5625 low dose|BIOLOGICAL: MT-5625 middle dose|BIOLOGICAL: MT-5625 high dose|BIOLOGICAL: Rotarix|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intensive Anti-Scoliosis Postural Intervention for Individuals With Rett Syndrome Supported by a Smartphone Application
Status: COMPLETED
Conditions: Rett Syndrome
Interventions: OTHER: Rehabilitative Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Insulin Stimulated Vasodilation in Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Type2 Diabetes
Interventions: DRUG: Insulin clamp|DRUG: BQ123|DRUG: BQ123 + BQ788
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Smart Technology Facilitated Patient-centered Care for Patients With Pulmonary Thromboembolism
Status: NOT_YET_RECRUITING
Conditions: Venous Thromboembolism|Pulmonary Thromboembolisms|Clinical Decision Support Systems|Digital Health
Interventions: OTHER: mobile venous thromboembolism application (mVTEA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Real-world Treatment Patterns and Clinical Outcomes in EGFR-mutant Unresectable Locally Advanced NSCLC
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer|Stage III Non-small-cell Lung Cancer|EGFR Mutation-Related Tumors
Interventions: RADIATION: radiation or chemo-radiation|DRUG: EGFR-TKI Inhibitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Low-Dose Ibuprofen in Improving Cognitive Impairment in Patients With Cancer
Status: COMPLETED
Conditions: Cognitive Impairment|Malignant Neoplasm
Interventions: DRUG: Ibuprofen|OTHER: Placebo|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluate Efficacy of Devimistat in Combination With mFFX in 2nd Line Patients With Metastatic Pancreatic Cancer
Status: WITHDRAWN
Conditions: Pancreatic Cancer Stage IV
Interventions: DRUG: CPI-613, modified Folfirinox
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Confocal Micro-endoscopy in Head and Neck Cancer/Micro Endoscopie Confocale (MEC)Oto-Rhino-Laryngologie (ORL)
Status: COMPLETED
Conditions: Malignant Pharyngo Laryngeal Tumors|Pre-malignant Pharyngo Laryngeal Tumors
Interventions: PROCEDURE: Confocal Micro Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: MEDI-557 Adult Dosing
Status: COMPLETED
Conditions: Respiratory Syncytial Virus
Interventions: DRUG: Placebo|DRUG: MEDI-557|DRUG: MEDI-557
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Comparison of Lithotripsy Urolithiasis Machines
Status: COMPLETED
Conditions: Kidney Stone|Kidney Calculi|Ureteral Calculi|Ureterolithiasis|Urolithiasis
Interventions: PROCEDURE: Lithotripter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of the Addition of Alanyl-Glutamine-Dipeptide to Dialysis Solution in Peritoneal Dialysis
Status: TERMINATED
Conditions: End Stage Renal Disease
Interventions: DRUG: Dipeptiven (Alanyl-glutamine-dipeptide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Safety by Basic Computerizing Outpatient Prescribing
Status: COMPLETED
Conditions: Adverse Drug Events
Interventions: OTHER: Basic Clinical Decision Support|OTHER: Routine Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Granulation Tissue Treatment: Silver Nitrate vs Kenalog vs Washcloth Abrasion
Status: TERMINATED
Conditions: Other Abnormal Granulation Tissue Nos
Interventions: DRUG: Silver Nitrate|DRUG: Kenalog (Triamcinolone)|OTHER: Washcloth Abrasion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Micro-Fragmented Adipose Tissue (Lipogems®) Injection for Chronic Shoulder Pain in Persons With Spinal Cord Injury
Status: UNKNOWN
Conditions: Shoulder Pain|Shoulder Impingement Syndrome|Rotator Cuff Impingement Syndrome|Rotator Cuff Tendinitis|Rotator Cuff Syndrome of Shoulder and Allied Disorders|Spinal Cord Injuries
Interventions: BIOLOGICAL: Autologous micro-fragmented adipose tissue|DEVICE: Lipogems system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Of En-Masse Retraction With Two-Step Retraction Using Mini-Implant As Anchorage
Status: COMPLETED
Conditions: En-masse Retraction to Two- Steps Retraction
Interventions: PROCEDURE: anterior retraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: CCCG-ALCL-2020 for Chinese Children and Adolescents With Newly Diagnosed High-risk ALCL
Status: RECRUITING
Conditions: Pediatric Anaplastic Large Cell Lymphoma
Interventions: DRUG: P regimen|DRUG: Course A1 + Vin|DRUG: Course B1 +Vin|DRUG: Course A2 + Vin|DRUG: Course B2 +Vin|DRUG: Course A3 + Vin|DRUG: Course B3 +Vin|DRUG: Maintenance therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of Single and Multiple Oral Doses of GLPG3667
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG3667 oral suspension|DRUG: Placebos|DRUG: GLPG3667 capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Circulating Tumor DNA in Patients Summoned for Colonoscopy; - a Liquid Biopsy for Detection, Characterization, Individualized Treatment and Follow-up of Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer|Colorectal Adenoma
Interventions: DIAGNOSTIC_TEST: liquid biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Sensory Motor Training on Balance and Proprioception Among Post-Menopausal Obese Women
Status: COMPLETED
Conditions: Post Menopaused Female
Interventions: OTHER: Sensorimotor training exercises|OTHER: Without Sensorimotor training exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Women's Recovery Group (WRG) Study - A Randomized Controlled Stage II Trial
Status: COMPLETED
Conditions: Substance-Related Disorders|Alcohol-Related Disorders
Interventions: BEHAVIORAL: The Women's Recovery Group|BEHAVIORAL: Group Drug Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Blood Levels of Sildenafil Following Administration of an Experimental Tablet vs. the Conventional Oral Tablet in Healthy Subjects.
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Sildenafil|DRUG: Sildenafil|DRUG: Sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pilot Study to Assess Efficacy and Safety of Pardoprunox as Adjunct Therapy to L-dopa in the Treatment of Patients With Parkinson's Disease Experiencing Motor Fluctuations and Dyskinesia.
Status: TERMINATED
Conditions: Advanced Stage Parkinson's Disease
Interventions: DRUG: pardoprunox|DRUG: pramipexole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ketamine's Effect Changes the Cortical Electrophysiological Activity Related to Semantic Affective Dimension of Pain
Status: COMPLETED
Conditions: Acute Pain|Chronic Pain, Widespread|Schizophrenia
Interventions: DRUG: Ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Epiceram™ Device Versus Mid-Strength Topical Steroid (Fluticasone Propionate 0.05%) for Treatment of Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DEVICE: Epiceram(r)|DRUG: Fluticasone Propionate 0.05%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: First-in-human Study in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CORT118335, 25 mg|DRUG: Prednisone Oral Tablet|DRUG: Glucose|DRUG: Placebo oral suspension|DRUG: CORT118335, 75mg|DRUG: CORT118335, 225mg|DRUG: CORT118335, 675mg|DRUG: CORT118335, 600mg|DRUG: CORT118335, 630mg|DRUG: CORT118335, 375mg|DRUG: CORT118335, 100mg|DRUG: CORT118335, 300mg|DRUG: CORT118335, 900mg|DRUG: CORT118335, 150mg|DRUG: CORT118335, 1500mg|DRUG: Placebo oral capsule|DRUG: CORT118335, dose to be determined
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment With Transcranial Magnetic Stimulation for Cocaine Addiction: Clinical Response and Functional Connectivity.
Status: UNKNOWN
Conditions: Cocaine-Related Disorders
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation|DEVICE: Repetitive Transcranial Magnetic Stimulation (Sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Giant Axonal Neuropathy|Gene Transfer
Interventions: GENETIC: scAAv9/JeT-GAN
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of Cast Bivalving for Pediatric Distal Radius Fractures
Status: ACTIVE_NOT_RECRUITING
Conditions: Distal Radius Fracture|Loss of Anatomical Alignment After Fracture Reduction
Interventions: RADIATION: Forearm anteroposterior and lateral plain radiograph
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use of Biodesign® Otologic Graft in Canal Wall Down Mastoidectomy: A Prospective, Randomized Trial
Status: WITHDRAWN
Conditions: Otologic Disease
Interventions: BIOLOGICAL: Biodesign Otologic graft|OTHER: Autograft temporalis fascia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Hodgkin Lymphoma|Non-Hodgkin Lymphoma|Myelodysplastic Syndrome|Myeloproliferative Syndrome|Rhabdomyosarcoma|Ewing Sarcoma|Primitive Neuroectodermal Tumor|Osteosarcoma|Neuroblastoma
Interventions: PROCEDURE: TCRαβ+/CD19+ depleted Haploidentical HSCT|DRUG: Zoledronate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Single-Dose, Comparative, Positive and Placebo Controlled, Four-Way, Four Period, Cross-Over Study to Evaluate the Effect of DIC075V on QTc Intervals in Healthy Subjects
Status: COMPLETED
Conditions: Ventricular Repolarization
Interventions: DRUG: DIC075V
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Study to Assess the Safety, Tolerability, and Preliminary Efficacy of ST266 in Infants With Necrotizing Enterocolitis
Status: RECRUITING
Conditions: Necrotizing Enterocolitis
Interventions: BIOLOGICAL: ST266
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improvement of the Performance of Lumbar Punctures After Training Students With an Augmented Reality SIMulator
Status: RECRUITING
Conditions: Lumbar Puncture
Interventions: OTHER: performing lumbar punctures by students with standard training|OTHER: training students augmented reality simulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of C-CAR168 in the Treatment of Autoimmune Diseases Refractory to Standard Therapy
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus (SLE)|Immune-Mediated Necrotizing Myopathy|Neuromyelitis Optica Spectrum Disorders|Multiple Sclerosis-Relapsing-Remitting|Myasthenia Gravis
Interventions: BIOLOGICAL: CD20/BCMA-directed CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ATG Versus Basiliximab in Kidney Transplant Displaying Low Immunological Risk But High Susceptibility to DGF
Status: TERMINATED
Conditions: Kidney Transplantation
Interventions: DRUG: Anti-Thymocyte Globulins treatment|DRUG: Basiliximab treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective, Multicentre, Open-label Study Evaluating 1.5 mg/Day of Fondaparinux.
Status: COMPLETED
Conditions: Major Orthopaedic Surgery and Renal Impairment
Interventions: DRUG: fondaparinux 1.5 mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Feasibility of Conducting a Pilot Telehealth Study Assessing the Removal of Filter Ventilation on Smoking Behavior and Biomarkers in Menthol Smokers Switched to Non-menthol Cigarettes
Status: RECRUITING
Conditions: Smoking
Interventions: OTHER: ventilated non-menthol cigarettes|OTHER: minimally ventilated non-menthol cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase I Trial to Determine the Safety and Pharmacokinetics of CRS3123.
Status: COMPLETED
Conditions: Clostridium Difficile Infection
Interventions: OTHER: Placebo|DRUG: CRS3123
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Relative Bioavailability of Two Iberdomide (CC-220) Formulations and to Assess The Effect Of Food on the Drug Levels of Iberdomide in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Iberdomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Remote Ischemic Postconditioning on Liver Graft and Renal Function in Patients Undergoing Living-related Liver Transplantation
Status: COMPLETED
Conditions: Ischemia/Reperfusion Injury of Liver Graft|Ischemia/Reperfusion Injury of Kidney|Remote Ischemic Postconditioning
Interventions: OTHER: RIPC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Optimizing Door-to-reperfusion Times of One-stop Management in Acute Ischemic Stroke
Status: ENROLLING_BY_INVITATION
Conditions: Acute Ischemic Stroke
Interventions: PROCEDURE: Standard workflow|PROCEDURE: One-stop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cryoablation Combined With Tirelizumab and Bevacizumab in Liver Metastatic TNBC Patients Failed by Multiline Therapy
Status: UNKNOWN
Conditions: Metastatic Breast Cancer in the Liver
Interventions: COMBINATION_PRODUCT: Cryoablation Combined with Tirelizumab and Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Diabetes-specific Cognitive Behavioural Treatment for Subthreshold Depression
Status: COMPLETED
Conditions: Depressive Symptoms|Diabetes Mellitus
Interventions: BEHAVIORAL: Diabetes-Specific CBT (DS-CBT)|BEHAVIORAL: Standard Diabetes Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Nitrate-rich Beetroot Juice Supplementation in Patients With Idiopathic Pulmonary Fibrosis (IPF)
Status: NOT_YET_RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis|Interstitial Lung Disease
Interventions: DIETARY_SUPPLEMENT: nitrate-rich beetroot juice (70ml with approx. 400 mg nitrate) twice a day for 3 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tenapanor in Synucleinopathy-Related Constipation
Status: NOT_YET_RECRUITING
Conditions: Synucleinopathy|Parkinson's Disease
Interventions: DRUG: Tenapanor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of rhPTH(1-84) in Subjects With Hypoparathyroidism
Status: TERMINATED
Conditions: Hypoparathyroidism
Interventions: BIOLOGICAL: rhPTH(1-84)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Sun Protection and Linear Repair of Cutaneous Surgical Defects
Status: RECRUITING
Conditions: Surgical Wound|Wound Heal|Wound of Skin|Scar
Interventions: OTHER: Zinc containing suncreen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05693 (P05713)
Status: COMPLETED
Conditions: Pregnancy|Neonates
Interventions: DRUG: corifollitropin alfa|BIOLOGICAL: recombinant Follicle Stimulating Hormone (recFSH)|BIOLOGICAL: human Chorion Gonadotropin (hCG)|BIOLOGICAL: hCG Bolus injection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intervention to REduce anticholinerGic burdEN in oldER pATiEnts (REGENERATE) Aged 65 Years and Older
Status: UNKNOWN
Conditions: Anticholinergic Adverse Reaction
Interventions: OTHER: ACB intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Oral Nifedipine to Treat Iron Overload
Status: COMPLETED
Conditions: Thalassemia|Iron Overload|Hemochromatosis
Interventions: DRUG: Nifedipine|PROCEDURE: Phlebotomy|PROCEDURE: Urinalysis|PROCEDURE: Echocardiogram|PROCEDURE: Electrocardiogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dapagliflozin to Prevent Atrial Fibrillation Recurrence After Transcatheter Pulmonary Venous Isolation.
Status: UNKNOWN
Conditions: Atrial Fibrillation Recurrent|Pulmonary Venous Isolation|Catheter Ablation|Sodium-glucose Co-transporter 2 Inhibitors
Interventions: DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of SAR339658 in Patients With Moderate to Severe Ulcerative Colitis
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: DRUG: SAR339658|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: HOPE-Duchenne (Halt cardiomyOPathy progrEssion in Duchenne)
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy|Cardiomyopathy
Interventions: DRUG: Allogeneic Cardiosphere-Derived Cells (CAP-1002)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: External Oblique Intercostal Plane Block Versus Transversus Abdominis Plane Block for Postoperative Analgesia in Adult Patients Undergoing Open Nephrectomy
Status: RECRUITING
Conditions: External Oblique Intercostal Plane Block|Transversus Abdominis Plane Block|Postoperative Analgesia|Nephrectomy
Interventions: OTHER: External Oblique Intercostal Plane Block|OTHER: Transversus Abdominis Plane Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Validation of Near-infrared Light Transillumination for Interproximal Enamel Caries Detection
Status: COMPLETED
Conditions: Dental Caries
Interventions: OTHER: Non invasive caries treatment|OTHER: Invasive caries treatment|DEVICE: Near-infrared light transillumination device (DIAGNOcam, KaVo, Biberach, Germany)|OTHER: Visual examination and bitewing (BW) radiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Beta-lactams on the Microbiota and Relative Fecal Abundance of Mulltidrug Resistant Bacteria
Status: COMPLETED
Conditions: Enterobacterial Infection
Interventions: DIAGNOSTIC_TEST: Stool culture ans swab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Non-resorbable Uveoscleral Implant Versus Absorbable Collagen Matrix in Non-perforating Deep Sclerectomy
Status: UNKNOWN
Conditions: Glaucoma
Interventions: PROCEDURE: non-perforating deep sclerectomy surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy Study of Fentanyl Iontophoretic Transdermal System (ITS) for Management of Moderate to Severe Acute Pain in Participants Who Have Undergone Elective Spine or Orthopedic Surgery
Status: TERMINATED
Conditions: Pain, Postoperative
Interventions: DRUG: Fentanyl ITS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose of Corticosteroids in COPD
Status: TERMINATED
Conditions: COPD
Interventions: DRUG: Low Dose Corticosteroids|DRUG: High Dose Corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Positive Feedback vs. No-Feedback Games for Behavioral Change
Status: NOT_YET_RECRUITING
Conditions: Major Depressive Disorder|Low Mood
Interventions: BEHAVIORAL: positive feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exenatide Study of Cardiovascular Event Lowering Trial (EXSCEL): A Trial To Evaluate Cardiovascular Outcomes After Treatment With Exenatide Once Weekly In Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Exenatide Once Weekly|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT