pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Campylobacter Enteritis and PI-BD: Dietary Reduction in Carbohydrates
Status: TERMINATED
Conditions: Post-infective Bowel Dysfunction|Functional Gastrointestinal Disorders
Interventions: BEHAVIORAL: low FODMAP dietary advice|DIETARY_SUPPLEMENT: Maltodextrin|DIETARY_SUPPLEMENT: Oligofructose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combining ICI With SBRT or HypoFrx-RT for ES NSCLC
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer|Non-small Cell Carcinoma|Non-small Cell Lung Cancer Stage I|Non-small Cell Lung Cancer Stage II|Non-small Cell Lung Cancer Stage III
Interventions: RADIATION: Stereotactic body radiotherapy|RADIATION: Hypofractionated radiotherapy|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mirtazapine for Treatment of Cancer Associated Anorexia-cachexia
Status: COMPLETED
Conditions: Advanced Cancer|Cancer Associated Anorexia - Cachexia
Interventions: DRUG: Mirtazapine 30 mg oral tablets|DRUG: Placebo oral tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SR604 in Two Participants Groups (Part A: Healthy Participants, and Part B: Participants With Hemophilia A or Hemophilia B)
Status: RECRUITING
Conditions: Healthy Participants|Hemophilia A|Hemophilia B
Interventions: DRUG: SR604|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study in Infants With Infantile Hemangioma to Compare Propranolol Gel to Placebo
Status: COMPLETED
Conditions: Infantile Hemangioma
Interventions: DRUG: propranolol gel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Avatar-Led Digital Therapeutic for Aiding Smoking Cessation in Sexual and Gender Minority Young Adults
Status: COMPLETED
Conditions: Cigarette Smoking-Related Carcinoma
Interventions: BEHAVIORAL: Online Smoking Cessation Intervention|BEHAVIORAL: Online Smoking Cessation Intervention|OTHER: Questionnaire Administration|OTHER: Health Promotion and Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Accuracy and Consequences of Using Trial-of-antibiotics for TB Diagnosis (ACT-TB Study)
Status: COMPLETED
Conditions: Tuberculosis|Respiratory Tract Infections|Pneumonia
Interventions: DRUG: Azithromycin|DRUG: Amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of LN-145/LN-145-S1 Autologous Tumor Infiltrating Lymphocytes in the Treatment of Squamous Cell Carcinoma of the Head & Neck
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: BIOLOGICAL: LN-145|BIOLOGICAL: LN-145-S1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Transcutaneous Electrical Stimulation on Post-stroke Dysphagic Patients
Status: COMPLETED
Conditions: Dysphagia
Interventions: DEVICE: VITALSTIM transcutaneous electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Model for Predicting Extubation Success in Premature Babies
Status: UNKNOWN
Conditions: Neonatal Respiratory Failure|Invasive Mechanical Ventilation|Extubation Failure
Interventions: OTHER: A model for predicting extubation success based on extubation readiness estimator and lung ultrasonography score
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Legtest Multi Centre Testing of the Lively Legs Program for Promoting Compliance in Leg Ulcer Patients
Status: COMPLETED
Conditions: Leg Ulcers|Varicose Ulcers
Interventions: BEHAVIORAL: Health Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mobile Health Technology for Personalized Tobacco Cessation Support Among Cancer Survivors in Laos
Status: COMPLETED
Conditions: Cigarette Smoking
Interventions: DRUG: Nicotine patch|BEHAVIORAL: Self-help materials (to support smoking cessation)|BEHAVIORAL: Smartphone-based automated treatment for smoking cessation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treatment Duration on Normobaric Hyperoxia in Acute Ischemic Stroke
Status: COMPLETED
Conditions: Stroke, Acute|Neuroprotection|Endovascular Treatment
Interventions: OTHER: Normobaric Hyperoxia (NBO)|OTHER: Low flow oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Neratinib Plus Capecitabine Versus Lapatinib Plus Capecitabine in Patients With HER2+ Metastatic Breast Cancer Who Have Received Two or More Prior HER2 Directed Regimens in the Metastatic Setting
Status: COMPLETED
Conditions: HER2+ Metastatic Breast Cancer (MBC)
Interventions: DRUG: neratinib|DRUG: capecitabine|DRUG: lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Phase I Study of Orally Available Novel Small-molecule Fibroblast Growth Factor Receptors (FGFR) 1,2,3 and 4 Inhibitor, ASP5878 at Single and Multiple Doses in Patients With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: ASP5878
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare GI Tolerability Following Oral Administration of Bafiertam™ or Tecfidera to Healthy Volunteers
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Bafiertam|DRUG: Tecfidera
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Early Intra-aortic Balloon Pump Placement in Acute Decompensated Heart Failure Complicated by Cardiogenic Shock
Status: RECRUITING
Conditions: Cardiogenic Shock
Interventions: COMBINATION_PRODUCT: Early intra-aortic balloon pump (IABP) implantation|OTHER: Standard of care as vasoactive agent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Efficacy, Safety and Tolerability of Four Different Doses of BI 409306 Compared to Placebo Given for 12 Weeks in Patients With Schizophrenia on Stable Antipsychotic Treatment.
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: BI 409306 100 mg QD|DRUG: BI 498306 50 mg QD|DRUG: Placebo|DRUG: BI 498306 25 mg QD|DRUG: BI 409306 10 mg QD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Efficacy Study of STX209 in Subjects With Fragile X Syndrome
Status: COMPLETED
Conditions: Fragile X Syndrome
Interventions: DRUG: STX209|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sodium Diet Effect on Aldosterone and Urinary RNA (SALTY)
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: High-sodium diet 300 mmol sodium/day|OTHER: Low-sodium diet 10 mmol sodium/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long-term Efficacy and Safety of HMS5552 add-on to Metformin in T2DM Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: HMS5552|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone as Adjuvant to Ropivacaine in Wound Infiltration for Postoperative Analgesia Following Spinal Surgery
Status: COMPLETED
Conditions: Lumbar Spinal Stenosis|Lumbar Disc Herniation|Lumbar Spondylolisthesis|Lumbar Spine Instability
Interventions: DRUG: Ropivacaine 0.75% Injectable Solution|DRUG: dexamethasone 8mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pecto-Intercostal Fascial Block for Postoperative Analgesia After Cardiac Surgery
Status: COMPLETED
Conditions: Coronary Artery Disease|Sternal Pain
Interventions: DRUG: Bupivacaine Group|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Topical Pirenzepine or Placebo in Oncology Patients With Chemotherapy Induced Peripheral Neuropathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Chemotherapy-induced Peripheral Neuropathy
Interventions: DRUG: WST-057 Active|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Adding Clopidogrel to Aspirin or Use of Metoprolol in Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: clopidogrel and metoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Assessment of Pathological Nipple Discharge With Delayed Ductal Imaging of Contrast-enhanced Mammography
Status: RECRUITING
Conditions: Nipple Discharge
Interventions: DIAGNOSTIC_TEST: contrast-enhanced spectral mammography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study Of CP-751,871 In Combination With Cisplatin And Gemcitabine In Chemotherapy-Naïve Patients With Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: CP-751,871|DRUG: Cisplatin|DRUG: Gemcitabine|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Surface Acoustic Waves on the Prevention of Colonization in Longterm Indwelling Urinary Caatheters
Status: UNKNOWN
Conditions: Baacterial Colonization|Urinary Tract Infections
Interventions: DEVICE: UroShield
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Brentuximab Vedotin and Nivolumab for the Treatment of Relapsed/Refractory Classic Hodgkin Lymphoma Previously Treated With Brentuximab Vedotin or Checkpoint Inhibitors
Status: RECRUITING
Conditions: Recurrent Classic Hodgkin Lymphoma|Refractory Classic Hodgkin Lymphoma
Interventions: DRUG: Brentuximab Vedotin|PROCEDURE: Hematopoietic Cell Transplantation|BIOLOGICAL: Nivolumab|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCL
Status: RECRUITING
Conditions: Large B-cell Lymphoma
Interventions: GENETIC: cemacabtagene ansegedleucel|BIOLOGICAL: ALLO-647|DRUG: Fludarabine|DRUG: Cyclophosphamide|DEVICE: Foresight CLARITY™ IUO MRD test, powered by PhasED-Seq™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of XL092 + Nivolumab vs Sunitinib in Subjects With Advanced or Metastatic Non-Clear Cell Renal Cell Carcinoma
Status: RECRUITING
Conditions: Non-Clear Cell Renal Cell Carcinoma
Interventions: DRUG: XL092|DRUG: Nivolumab|DRUG: Sunitinib Malate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Amlodipine-folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine
Status: UNKNOWN
Conditions: Essential Hypertension
Interventions: DRUG: Amlodipine|DRUG: amlodipine-FA tablet, low dose group|DRUG: amlodipine-FA tablet ,high dose group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics, and Antitumor Activity of AK114
Status: UNKNOWN
Conditions: Advanced or Metastatic Solid Tumors|Malignancy|Metastasis
Interventions: DRUG: AK114
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Red Cell Transfusion Goals in Patients With Acute Leukemias
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Acute Lymphocytic Leukemia (ALL)|Acute Myelogenous Leukemia (AML)|Acute Promyelocytic Leukemia (APL)
Interventions: BIOLOGICAL: Red blood cell transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Transversus Abdominis Plane Block From Abdominal Approach
Status: UNKNOWN
Conditions: Transversus Abdominis Plane Block From Abdominal Approach
Interventions: PROCEDURE: Transversus abdominis plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Local Anesthetic Concentration for Continuous Lumbar Plexus Nerve Blocks
Status: COMPLETED
Conditions: Hip Arthroplasty|Hip Pain
Interventions: DRUG: 0.1% Ropivacaine|DRUG: 0.4% Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Switch Study to Evaluate Dolutegravir Plus Lamivudine in Virologically Suppressed Human Immunodeficiency Virus Type 1 Positive Adults (TANGO)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: DTG + 3TC|DRUG: TAF based regimen (TBR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Disorders During Exercise in Patients With Obstructive Sleep Apnea
Status: UNKNOWN
Conditions: Sleep Apnea, Obstructive|Asthma, Exercise-Induced
Interventions: DEVICE: continuous positive airway pressure (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of OPC-415 in Patients With Relapsed and/or Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma (MM)
Interventions: BIOLOGICAL: OPC-415
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Helmet NIV in Acute Respiratory Failure
Status: RECRUITING
Conditions: Acute Respiratory Failure
Interventions: DEVICE: Helmet Non-Invasive Ventilation|DEVICE: Facemask Non-Invasive Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Variations and Pain Assessment in Newborns Submitted to Intratracheal Aspiration With Open and Closed System
Status: COMPLETED
Conditions: Adverse Reaction to Systemic Agents
Interventions: DEVICE: Tracheal aspiration close system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMplementation of an RCT to imProve Treatment With Oral AntiCoagulanTs in Patients With Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation|Stroke
Interventions: BEHAVIORAL: Early Patient-Level and Provider-Level Educational Intervention|BEHAVIORAL: Delayed Provider-Level Educational Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Training Response Artificial Intelligence Network (TRAIN)
Status: RECRUITING
Conditions: Amnestic Mild Cognitive Impairment
Interventions: BEHAVIORAL: Cognitive Training|BEHAVIORAL: Computerized Cognitive Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Provider-Targeted Behavioral Interventions to Prevent Unsafe Opioid Prescribing for Acute Pain in Primary Care
Status: UNKNOWN
Conditions: Acute Pain|Headache|Musculoskeletal Pain
Interventions: BEHAVIORAL: Usual Care/Guideline|BEHAVIORAL: Opioid Justification|BEHAVIORAL: Provider Comparison
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Giving Gene Marked EBV Specific T-Cells to Patients Receiving a BMT for Relapsed EBV-Positive Hodgkin Disease
Status: TERMINATED
Conditions: Hodgkin Disease|Non-Hodgkins Lymphoma
Interventions: DRUG: Infusion of EBV Specific Cytotoxic T-Lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Chemotherapy in Triple Negative Invasive Breast Cancer That Can be Removed by Surgery.
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Bevacizumab, nab-paclitaxel, carboplatin, doxorubicin hydrochloride, cyclophosphamide, PEG-Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pancreatic Enzymes and Bile Acids in Acutely Ill Severely Malnourished Children
Status: ACTIVE_NOT_RECRUITING
Conditions: SEPSIS|MALNUTRITION, CHILD
Interventions: DRUG: Pancreatic Enzyme|DRUG: Ursodeoxycholic acid|OTHER: Pancreatic Enzyme placebo|OTHER: Ursodeoxycholic acid placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: (D)Elayed vs. (E)Arly (L)Aparoscopic (A)Ppendectom(Y)
Status: COMPLETED
Conditions: Appendicitis
Interventions: PROCEDURE: Appendectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Liver Fibrosis, Lipid Profile and Insulin Resistance in HCV Patients Who Received Antiviral Therapy
Status: COMPLETED
Conditions: Chronic Hepatitis c
Interventions: DIAGNOSTIC_TEST: lipid profile|DIAGNOSTIC_TEST: fasting insulin|DIAGNOSTIC_TEST: fibro scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Bioactive Resin Varnish and Fluoride Containing Xylitol Varnish in Management of Teeth Hypersensitivity
Status: UNKNOWN
Conditions: Tooth Hypersensitivity
Interventions: OTHER: PRG Barrier Coat (By SHOFU Inc., Japan)|OTHER: EMBRACE™ Varnish by (Pulpdent Corporation, USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Response Predictors of Adjuvant Astragalus for Cognition in Orthostatic Hypotension
Status: RECRUITING
Conditions: Orthostatic Hypotension|Alzheimer Disease
Interventions: BEHAVIORAL: Routine treatment|DRUG: add-on low dose Astragalus|DRUG: add-on high dose Astragalus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Guideline Approach to Therapy Step-down Utilising Flutiform Change and Step-down
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone 250/formoterol 10|DRUG: Fluticasone 250/salmeterol 25|DRUG: Fluticasone 125/formoterol 5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label, Post-marketing, Prospective Study to Assess Impact of COVID-19 on Cognitive Function in Patients
Status: UNKNOWN
Conditions: Cognitive Decline|Cognitive Dysfunction|Brain Health|Post CoV-2 Syndrome|COVID Long-Haul
Interventions: DEVICE: Cognivue
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Characterization of Hyperparathyroidism and Vitamin D Deficiency in Obesity
Status: COMPLETED
Conditions: Vitamin D Deficiency|Secondary Hyperparathyroidism|Obesity
Interventions: DRUG: Ergocalciferol|DRUG: Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Fasted Exercise on Improving Cardiometabolic Health
Status: RECRUITING
Conditions: Cardiovascular Diseases|Diabetes Mellitus, Type 2|Obesity
Interventions: OTHER: Exercise training in the fasted state|OTHER: Exercise training in the fed state
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Open-label Phase II Study of Lorvotuzumab Mertansine
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Lorvotuzumab Mertansine (IMGN901)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Tolerability Extension Trial Assessing Repeated Dosing of Anti-KIR (1-7F9) Human Monoclonal Antibody in Patients With Acute Myeloid Leukaemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: IPH2101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Participants With Rheumatoid Arthritis
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: LY2127399|DRUG: Placebo Q4W|DRUG: Placebo Q2W
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hu3S193 in Treating Women With Ovarian Epithelial, Primary Peritoneal, or Fallopian Tube Cancer
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cancer
Interventions: BIOLOGICAL: hu3S193
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of the Self-Care Immediate Stabilization Procedure (ISP) ® After a Traumatic Experience
Status: NOT_YET_RECRUITING
Conditions: Post-traumatic Stress Disorder|Acute Stress Disorder
Interventions: BEHAVIORAL: Eye Movement Desensitization and Reprocessing (EMDR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study in Participants With Acute Migraines Headaches
Status: TERMINATED
Conditions: Migraine Headache
Interventions: DRUG: LY2590443|DRUG: Placebo injection|DRUG: Sumatriptan|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ondansetron for Postspinal Anesthesia Hypotension
Status: COMPLETED
Conditions: Adverse Effect
Interventions: DRUG: normal saline|DRUG: Ondansetron 4 mg|DRUG: Ondansetron 8 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Comparing Supplemental Topical Agents for the Treatment of Acute Radiation Dermatitis in Patients With Breast Cancer
Status: RECRUITING
Conditions: Breast Ductal Carcinoma In Situ|Invasive Breast Carcinoma
Interventions: DRUG: Agent Affecting Integumentary System|OTHER: Petrolatum-Mineral Oil-Lanolin-Ceresin Ointment|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: QUILT-2.008: Study of ALT-801 With Cisplatin in Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Metastatic Melanoma
Interventions: DRUG: Cisplatin|BIOLOGICAL: ALT-801
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of TCAV and Volume Control Ventilation on the Distribution of Aerated Lung Parenchyma in ARDS Patients
Status: RECRUITING
Conditions: ARDS
Interventions: OTHER: Time-controlled adaptative ventilation (TCAV)|OTHER: Volume-controlled ventilation (VCV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stellate Ganglion Block Combined With Dexmedetomidine or Subanesthetic Ketamine Infusion for Treatment of Neurostorm.
Status: ENROLLING_BY_INVITATION
Conditions: Paroxysmal Sympathetic Hyperactivity
Interventions: PROCEDURE: Stellate ganglion block|DRUG: Dexmedetomidine|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Growth Hormone Signaling in Vivo in Humans
Status: COMPLETED
Conditions: Intracellular Signaling Peptides and Proteins
Interventions: DRUG: Saline infusion|DRUG: Human Growth Hormone|DRUG: Pegvisomant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial for HER2 Positive Breast Cancer Patients With Metastatic Disease
Status: COMPLETED
Conditions: Breast Neoplasms|Cancer of the Breast|Breast Cancer
Interventions: DRUG: Gemcitabine|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Duration Therapeutic Ultrasound on Tendon Injuries
Status: TERMINATED
Conditions: Tendon Injuries|Musculoskeletal Pain
Interventions: DEVICE: Therapeutic ultrasound|DEVICE: Placebo therapeutic ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Niacin/Laropiprant and Endothelial Function
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DRUG: Niacin/laropiprant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavior Therapy (CBT) Compared to Stress Management for Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: BEHAVIORAL: Cognitive behavior therapy|BEHAVIORAL: Stress management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Citalopram for Cocaine Dependence
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: Citalopram|DRUG: Citalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IvaBRAdine blocK of Funny Current for Heart Rate Control in permanEnt Atrial Fibrillation. (BRAKE-AF Study).
Status: COMPLETED
Conditions: Atrial Fibrillation|Heart Diseases
Interventions: DRUG: Ivabradine|DRUG: Digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Transcranial Direct Current Stimulation Montages in Stroke
Status: UNKNOWN
Conditions: Acute Stroke
Interventions: DEVICE: Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vinflunine and Erlotinib or Pemetrexed in Treating Patients With Unresectable or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: erlotinib hydrochloride|DRUG: pemetrexed disodium|DRUG: vinflunine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia
Status: RECRUITING
Conditions: Anarthria|Dysarthria|Tetraplegia|Spinal Cord Injuries|Amyotrophic Lateral Sclerosis|Brain Stem Infarctions|Locked in Syndrome|Muscular Dystrophies
Interventions: DEVICE: BrainGate Neural Interface System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of a Decision Aid on Decision Making for Family Member's Disclosure of Terminal Illness
Status: COMPLETED
Conditions: Terminal Illness
Interventions: BEHAVIORAL: Providing tailored message on disclosing terminal illness|BEHAVIORAL: Providing non-tailored message on pain control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Autologous Bone Marrow Stem Cell Transfer in Patients With Chronical Critical Limb Ischemia and Diabetic Foot
Status: COMPLETED
Conditions: Critical Limb Ischemia
Interventions: PROCEDURE: BMAC application in Critical Limb Ischemia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Huperzine A Injection on Postoperative Cognitive Dysfunction in Patients With Aneurysmal Subarachnoid Hemorrhage: a Pilot Study
Status: NOT_YET_RECRUITING
Conditions: Postoperative Cognitive Dysfunction in Patients With Aneurysmal Subarachnoid Hemorrhage
Interventions: DRUG: Huperzine A injection, operational treatment, the best basic treatment|OTHER: operational treatment, the best basic treatment|DRUG: Huperzine A injection, interventional treatment, the best basic treatment|OTHER: Interventional treatment, the best basic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Pandemic Stress Vaccine: A Resource to Enhance the Resilience of Healthcare Workers Facing an Infectious Outbreak
Status: TERMINATED
Conditions: Psychological Stress
Interventions: BEHAVIORAL: Interactive computerized learning resource|BEHAVIORAL: Didactic computerized learning resource
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study To Evaluate The Efficacy And Safety of The Investigational Drug PF-03446962 (A Monoclonal Antibody With Antiangiogenic Features) In Combination With Best Supportive Care Versus Placebo Plus Best Supportive Care In Patients Affected By Recurrent Liver Cancer
Status: TERMINATED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: PF-03446962|OTHER: Best Supportive Care|OTHER: Placebo|OTHER: Best Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preliminary Efficacy and Safety Study of ST101 in Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: ST101|DRUG: ST101|DRUG: ST101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cilengitide in Treating Children With Refractory Primary Brain Tumors
Status: COMPLETED
Conditions: Childhood Central Nervous System Germ Cell Tumor|Childhood Choroid Plexus Tumor|Childhood Craniopharyngioma|Childhood Ependymoblastoma|Childhood Grade I Meningioma|Childhood Grade II Meningioma|Childhood Grade III Meningioma|Childhood High-grade Cerebellar Astrocytoma|Childhood High-grade Cerebral Astrocytoma|Childhood Infratentorial Ependymoma|Childhood Low-grade Cerebellar Astrocytoma|Childhood Low-grade Cerebral Astrocytoma|Childhood Medulloepithelioma|Childhood Mixed Glioma|Childhood Oligodendroglioma|Childhood Supratentorial Ependymoma|Recurrent Childhood Brain Stem Glioma|Recurrent Childhood Brain Tumor|Recurrent Childhood Cerebellar Astrocytoma|Recurrent Childhood Cerebral Astrocytoma|Recurrent Childhood Ependymoma|Recurrent Childhood Medulloblastoma|Recurrent Childhood Pineoblastoma|Recurrent Childhood Subependymal Giant Cell Astrocytoma|Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor|Recurrent Childhood Visual Pathway and Hypothalamic Glioma
Interventions: DRUG: cilengitide|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of RBN-2397, an Oral PARP7 Inhibitor, in Patients With Solid Tumors
Status: UNKNOWN
Conditions: Solid Tumor, Adult
Interventions: DRUG: RBN-2397
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Hyaluronan Thiomer i.o. Implant During Combined Phacoemulsification - Non Penetrating Deep Sclerectomy
Status: COMPLETED
Conditions: Open Angle Glaucoma|Cataract
Interventions: DEVICE: Hyaluronan Thiomer i.o. implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-Center, Open-label Study Evaluate the Efficacy and Tolerability of a Dual Skincare Regimen Treatment for Facial Hyperpigmentation and Photodamaged Skin in Patients Exposed to Extrinsic Factors of Aging
Status: COMPLETED
Conditions: Hyperpigmentation|Photodamaged Skin|Wrinkle|Fine Lines
Interventions: OTHER: Gentle Cleansing Lotion, Revision Skincare
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Anterior Segment Imaging With Ultrahigh-resolution OCT in Patients With Glaucoma and PEX - a Pilot Study
Status: UNKNOWN
Conditions: Glaucoma
Interventions: DRUG: Pilocarpine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Pollution on Allergic Rhinitis and Sleep Quality: the POLLAR Study
Status: COMPLETED
Conditions: Sleep Apnea|Allergic Rhinitis|Allergic Asthma|Pollution Exposure|Pollution Related Respiratory Disorder
Interventions: OTHER: Pollution exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Gastric Bypass and Peripheral Activity of the Endocannabinoid System
Status: COMPLETED
Conditions: Obesity
Interventions: BIOLOGICAL: Evaluation of the endocannabinoid system|PROCEDURE: Biopsy of visceral and peripheral adipose tissue|BIOLOGICAL: Evaluation of metabolic parameters|BEHAVIORAL: Evolution of behavioral parameters|BEHAVIORAL: Dietician consultation|BEHAVIORAL: Psychologist consultation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Serplulimab Plus Chemoradiotherapy for Stage III-IVA Cervical Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: Serplulimab|DRUG: Cisplatin|DRUG: Carboplatin|RADIATION: Brachytherapy and External Beam Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Virtual Reality Training Compared to Traditional Exercise in Patients With Frozen Shoulder
Status: RECRUITING
Conditions: Frozen Shoulder
Interventions: OTHER: Virtual reality exercise training|OTHER: Traditional exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Quality of Life in Patients With Metastatic Melanoma Treated With Checkpoint Inhibitors
Status: COMPLETED
Conditions: Metastatic Melanoma
Interventions: BEHAVIORAL: EuroQoL EQ-5D-3L|BEHAVIORAL: EORTC QLQ-C30|OTHER: PRO-CTCAE|BEHAVIORAL: Fatigue severity score questionnaire|BEHAVIORAL: The COST|BEHAVIORAL: Physician information
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Neoadjuvant Letrozole + Taselisib Versus Letrozole + Placebo in Post-Menopausal Women With Breast Cancer (LORELEI)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Letrozole|OTHER: Placebo|DRUG: Taselisib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Action Observation Therapy on Pain, Functional Level and Brain Hemodynamic in Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Pain, Chronic|Osteoarthritis, Knee
Interventions: OTHER: Action observation therapy|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of Carbidopa-Levodopa Extended-Release Tablets in Patients With Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: DRUG: WD-1603 Carbidopa-Levodopa Extended-Release Tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bupivacaine With Dexmedetomidine Versus Bupivacaine Alone for Transversus Abdominis Plane Block in Caesarean Section
Status: COMPLETED
Conditions: Post Operative Pain
Interventions: PROCEDURE: Transversus Abdominis Plane Block with bupivacain Plus dexamethasone|PROCEDURE: Transversus Abdominis Plane Block with bupivacain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety, Tolerability and Immunogenicity of V114 in Healthy Adults and Infants (V114-005)
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: V114 Medium Dose|BIOLOGICAL: V114 High Dose|BIOLOGICAL: V114 Medium Dose with Alternative Carrier Protein|BIOLOGICAL: V114 High Dose with Alternative Carrier Protein|BIOLOGICAL: Prevnar 13™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Aspects of a Standardized Stepwise Anatomical Approach for AVNRT Ablation
Status: WITHDRAWN
Conditions: Re-entrant Atrioventricular Node Tachycardia
Interventions: PROCEDURE: Coronary sinus / left-sided slow pathway ablation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of Vertical Root Fracture Resistance of Endodontically Treated Teeth Instrumented by Single Endodontic Files
Status: COMPLETED
Conditions: Vertical Fracture of Root of Tooth (Disorder)
Interventions: PROCEDURE: Endodontic Root Canal Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Environmental, Metabolic and Nutritional Factors of Hepatocellular Carcinoma in Cirrhotic Patients
Status: COMPLETED
Conditions: Cirrhosis With Hepatocellular Carcinoma|Cirrhosis Without Hepatocellular Carcinoma
Interventions: BIOLOGICAL: Serum, plasma and DNA samples|PROCEDURE: Radiological exploration by CT scan or MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Salsalate in Patients Mild to Moderate Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: DRUG: Salsalate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Study of Pharmacokinetics and Pharmacodynamics of Cisatracurium
Status: COMPLETED
Conditions: Critical Illness|Respiratory Distress Syndrome, Adult|Neuromuscular Blockade|Respiratory Failure|Paralysis|ARDS, Human
Interventions: DRUG: cisatracurium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long-Arm vs Sugar-Tong
Status: WITHDRAWN
Conditions: Closed Fracture of Shaft of Ulna|Closed Fracture of Shaft of Radius
Interventions: DEVICE: Long-Arm Cast|DEVICE: Sugar-Tong Splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of IFABONDTM Synthetic Glue for Fixation of Implanted Material in Laparoscopic Sacrocolpopexy: a Prospective Multicenter Study
Status: COMPLETED
Conditions: Medial and/or Anterior Genital Prolapse
Interventions: PROCEDURE: fixation technique using a sterile synthetic liquid tissue glue: IFABOND™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-Dose Study to Assess the Pharmacokinetics of Cabozantinib (XL184) Capsules in Subjects With Impaired Renal Function
Status: COMPLETED
Conditions: Healthy|Renal Impairment
Interventions: DRUG: cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise And Rosuvastatin Treatment: Is There an Anti-Inflammatory Synergy?
Status: UNKNOWN
Conditions: Nonfamilial Hypercholesterolemia|Physical Inactivity
Interventions: DRUG: Rosuvastatin|BEHAVIORAL: Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Safety and Efficacy of Therapy for the Prevention of Weight Gain Associated With Olanzapine
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorders
Interventions: DRUG: olanzapine|DRUG: amantadine|DRUG: metformin|DRUG: zonisamide|BEHAVIORAL: Wellness education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 3 Clinical Trial to Compare RBS-001 to Eylea® in Subjects With Neovascular Age-Related Macular Degeneration
Status: NOT_YET_RECRUITING
Conditions: Neovascular Age-related Macular Degeneration (nAMD)
Interventions: DRUG: RBS-001 Solution for intravitreal injection|DRUG: Eylea® Solution for intravitreal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Chi-BEAC Combining With Auto-HSCT to Treat Aggressive Lymphoma Subjects
Status: UNKNOWN
Conditions: Lymphoma, Large B-Cell, Diffuse|Mantle Cell Lymphoma|Peripheral T Cell Lymphoma|Double-hit Lymphoma
Interventions: DRUG: Chidamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic, Safety, Tolerability and Immunogenicity Study of SB3 in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: SB3|BIOLOGICAL: EU sourced Herceptin®|BIOLOGICAL: US sourced Herceptin®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate an Influenza Vaccine Candidate
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Candidate Influenza Vaccine GSK1247446A - 2 different formulations|BIOLOGICAL: FluarixTM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Chemoimmunotherapy Versus Concurrent Chemoradiotherapy for LACC
Status: NOT_YET_RECRUITING
Conditions: Cervical Cancer|Locally Advanced Cervical Cancer|Concurrent Chemoradiotherapy|Neoadjuvant Chemoimmunotherapy
Interventions: DRUG: Camrelizumab|DRUG: Cisplatin|DRUG: Nab paclitaxel|PROCEDURE: Radical surgery|RADIATION: external beam radiation therapy (EBRT) + brachytherapy|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ORal IrON Supplementation With Ferric Maltol in Patients With Pulmonary Hypertension (ORION-PH-1)
Status: TERMINATED
Conditions: Hypertension, Pulmonary|Anemia, Iron Deficiency
Interventions: DRUG: Ferric maltol 30 mg (Feraccru®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT