pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Theanine and Caffeine on Neurophysiology of Attention
Status: COMPLETED
Conditions: L-theanine
Interventions: OTHER: Theanine|OTHER: Caffeine|OTHER: Theanine-Caffeine Combination|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: A Randomised Controlled Clinical Trial on the Use of a Dental Aerosol Box to Prevent Microbial Transmission During Dental Procedure
Status: COMPLETED
Conditions: Calculi
Interventions: DEVICE: Conventional suction system|DEVICE: Dental aerosol box with modified high volume evacuation system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Comparing the Efficacy of 2 RIC Regimens (Clofarabine vs Fludarabine) in Adults With AML Eligible to Allo-SCT
Status: RECRUITING
Conditions: Acute Myeloid Leukemia in Remission
Interventions: DRUG: Fludarabine|DRUG: Busulfan|DRUG: ATG|DRUG: Clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnosing Deep-vein Thrombosis Early in Critically Ill Patients
Status: RECRUITING
Conditions: Deep Vein Thrombosis|Pulmonary Embolism
Interventions: DIAGNOSTIC_TEST: Proximal lower limb ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Impact of Multi-Component Interventions on High-Risk COPD Smokers
Status: NOT_YET_RECRUITING
Conditions: Multimorbidity|Tobacco Use Cessation|Smoking Reduction
Interventions: COMBINATION_PRODUCT: Multi-component intervention for smokers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase I Oral mTOR Inhibitor RAD001 in Combo w/ Capecitabine for Metastatic Breast
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Capecitabine|DRUG: RAD001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Topical Indigo Naturalis Treatment in Patients With Mild to Moderate Plaque-type Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Indigo naturalis ointment|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Literacy Level on Patient Education and Health Among People With Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Psoriatic Arthritis|Polyarthritis
Interventions: BEHAVIORAL: 11th grade reading level arthritis materials|BEHAVIORAL: Interactive in-person arthritis education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Clinical Study of Selective Fecal Microbiota Transplantation in the Treatment of Irritable Bowel Syndrome.
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome Variant of Childhood
Interventions: PROCEDURE: Standardized FMT|COMBINATION_PRODUCT: Precision Flora Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of AK104, a PD-1/CTLA-4 Bispecific Antibody in Subjects With Recurrent/Metastatic Cervical Cancer
Status: COMPLETED
Conditions: Recurrent Cervical Cancer|Metastatic Cervical Cancer
Interventions: BIOLOGICAL: AK104
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess the Efficacy of Investigational Product on the Neuropathic Pain in Individuals Suffering From Type II Diabetes Mellitus.
Status: COMPLETED
Conditions: Diabetic Neuropathies|Insomnia Due to Medical Condition
Interventions: OTHER: NeuropAWAY|OTHER: Microcystalline cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Methylsulfonylmethane (MSM) in the Treatment of Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: MSM 1000mg twice a day (6000 mgs)|OTHER: Placebo capsules twice a day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Titration and Open-label Extension Study of SRP-4045 in Advanced Stage Duchenne Muscular Dystrophy (DMD) Patients
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: SRP-4045|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine and Hypoxic Pulmonary Vasoconstriction in Thoracic Surgical Procedures and One-Lung Ventilation
Status: COMPLETED
Conditions: Esophageal Cancer|Lung Cancer|Chest Wall Disorders
Interventions: DRUG: Dexmedetomidine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase I/II Clinical Study of SAF-189s in Non-small Cell Lung Cancer (NSCLC) Patients
Status: RECRUITING
Conditions: Advanced Cancer|Advanced Solid Tumor|Lung Cancer, Nonsmall Cell
Interventions: DRUG: SAF-189s
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept Study of Cognitive Improvement in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: AZD3480
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Home-based Pulmonary Rehabilitation Program in COPD Patients
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease|Pulmonary Rehabilitation
Interventions: OTHER: Maintenance programme|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Safety and Efficacy of Paclitaxel Controlled Release Balloon Catheter (VasoguardTM) in the Treatment of Small Coronary Vessel Stenosis With a Common Coronary Balloon Catheter (Maverick2)
Status: UNKNOWN
Conditions: Small Vessel Lesion
Interventions: DEVICE: paclitaxel controlled release balloon catheter (VasoguardTM)|DEVICE: common balloon catheter (Maverick2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Motivational Interview-based Self-management Training
Status: COMPLETED
Conditions: COPD|Motivational Interviewing|Self Management|Self-Efficacy|Psychiatric Nursing
Interventions: BEHAVIORAL: Motivational İnterviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Exercise and Nutrition Monitoring Intervention (Pt Pal) for the Improvement of Strength in Patients With Pancreatic or Stomach Cancer Receiving Chemoradiation Therapy Before Surgery, SurgeryStrong Study
Status: WITHDRAWN
Conditions: Gastric Adenocarcinoma|Pancreatic Adenocarcinoma
Interventions: OTHER: Aerobic Exercise|OTHER: Dietary Intervention|OTHER: Nutritional Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|OTHER: Resistance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy, Safety & Tolerability of Switching EFV/TDF/FTC to BIC/FTC/TAF in Virologically Suppressed Adults With HIV-1
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: bictegravir/emtricitabine/tenofovir alafenamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Eribulin and Pembrolizumab in Soft Tissue Sarcomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Sarcoma|Liposarcoma|Leiomyosarcoma|Undifferentiated Pleomorphic Sarcoma
Interventions: DRUG: Eribulin|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever
Status: COMPLETED
Conditions: Hemorrhagic Fever With Renal Syndrome
Interventions: BIOLOGICAL: HTNV/PUUV DNA vaccine|BIOLOGICAL: Placebo|DEVICE: TriGrid Delivery System (TDS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to See How Safe a New Medicine (NNC6022-0001) is in Healthy People
Status: RECRUITING
Conditions: Healthy Volunteers|Cardiometabolic Diseases
Interventions: DRUG: NNC6022-0001|DRUG: Placebo (NNC6022-0001)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Alectinib (CH5424802/RO5424802) in Participants With Anaplastic Lymphoma Kinase (ALK)-Rearranged Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Alectinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postpartum Care Timing: A Randomized Trial
Status: COMPLETED
Conditions: Postpartum|Pregnancy Related
Interventions: BEHAVIORAL: Postpartum Visit at 6 Weeks|BEHAVIORAL: Postpartum Visit at 2 Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Fractional Ablative Laser Treatment for Skin Grafts
Status: COMPLETED
Conditions: Burn Scar|Skin Graft Scar
Interventions: DRUG: Lidocaine Cream|DRUG: Triamcinolone Acetonide Cream|DEVICE: Fractional Ablative Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Dialectical Behavior Therapy in Patients With Borderline Personality Disorder
Status: COMPLETED
Conditions: Borderline Personality Disorder
Interventions: BEHAVIORAL: Dialectical behavior therapy (DBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Conventional Laparoscopic Hysterectomy Versus Robot-Assisted Laparoscopic Hysterectomy at a Teaching Institution
Status: TERMINATED
Conditions: Menorrhagia|Dysfunctional Uterine Bleeding|Leiomyoma|Pelvic Pain|Endometriosis
Interventions: PROCEDURE: Conventional Laparoscopic Hysterectomy (LH)|PROCEDURE: Robot Assisted Hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized CT to Evaluate Efficacy of Neoadjuvant Chemotherapy Customized by Levels of BRCA1-HER2 Negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Epirubicin + Ciclofosfamide + Fluorouracil + Paclitaxel|DRUG: Epirubicin + Cisplatin + Fluorouracil|DRUG: Docetaxel + Ciclofosfamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Ultrasound Scanning of the Lumbar Spine Improve Patient Satisfaction and the Ease of Insertion Epidurals?
Status: COMPLETED
Conditions: Labor Pain
Interventions: DEVICE: Portable ultrasound machine|DEVICE: Portable ultrasound machine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multifunctional Cataract Surgery Assistive Instruments Used in Cataract Surgery
Status: NOT_YET_RECRUITING
Conditions: Cataract
Interventions: DEVICE: multifunctional instruments|DEVICE: traditional instruments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Pseudoephedrine HCl 120 mg ER Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pseudoephedrine hydrochloride 120 mg ER tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Comparing of the Pharmacokinetic, Safety and Pharmacodynamic of QL1206 and Prolia® in Healthy Adults
Status: UNKNOWN
Conditions: Healthy People
Interventions: DRUG: QL1206|DRUG: Prolia®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel-Coated Pulmonary Balloon for the Treatment of Benign Airway Stenosis
Status: RECRUITING
Conditions: Central Airway Obstruction
Interventions: COMBINATION_PRODUCT: Paclitaxel-Coated Pulmonary Balloon Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: nTMS in Planning Stereotactic Radiosurgery in Patients With Brain Metastases in the Motor Cortex
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Malignant Neoplasm in the Brain|Radiation Therapy Recipient
Interventions: BEHAVIORAL: Hand Function Test|PROCEDURE: Navigated Transcranial Magnetic Stimulation|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ivabradine to Prevent Anthracycline-induced Cardiotoxicity
Status: UNKNOWN
Conditions: Neoplasms|Heart Failure|Cardiotoxicity|Chemotherapy Effect|Oncology
Interventions: DRUG: Ivabradine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Peroral Endoscopic Myotomy (POEM) With Laparoscopic Heller Myotomy (LHM) for Treatment of Achalasia
Status: TERMINATED
Conditions: Comparison of Short- Term Success Rates of POEM With LHM|Comparison of Long-term Success Rates of POEM With LHM
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Robotic Exoskeleton Assisted Gait Post Stroke
Status: UNKNOWN
Conditions: CVA|Gait, Hemiplegic
Interventions: DEVICE: EksoGT™, Ekso Bionics, Berkley, CA, USA|OTHER: Standard of Care|OTHER: No Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib, Bevacizumab, and Oxaliplatin in Treating Patients With Metastatic Malignant Melanoma
Status: UNKNOWN
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: bevacizumab|DRUG: oxaliplatin|DRUG: sorafenib tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the My Hematology Oncology Patient Experience (MyHOPE™) For Multiple Myeloma (MM) Digital Care Network in Patients With MM
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DEVICE: MyHOPE™ for Multiple Myeloma|DEVICE: MyHope HCP Portal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sunitinib Malate Before and After Surgery in Treating Patients With Previously Untreated Metastatic Kidney Cancer
Status: COMPLETED
Conditions: Kidney Cancer
Interventions: DRUG: sunitinib malate|OTHER: laboratory biomarker analysis|PROCEDURE: adjuvant therapy|PROCEDURE: neoadjuvant therapy|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endothelial Function Evaluation in Patients With PAOD Treated With Sulodexide + Conventional Treatment (CT) Vs CT Alone
Status: UNKNOWN
Conditions: Peripheral Arterial Obstructive Disease
Interventions: DRUG: Sulodexide|DRUG: Statin|DRUG: Antiplatelet Agents|DRUG: ACE inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 STudy of CaPRe In LOwering Very hiGh TriglYcerides (TRILOGY 1)
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DRUG: CaPre|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hormone and Information Processing Study
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Alzheimer's Disease
Interventions: DRUG: testosterone gel|DRUG: placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Residual Allergenicity of Tree (Birch, Hazel, and Alder) Pollen Allergoid Using Skin Prick Testing
Status: COMPLETED
Conditions: Type I Hypersensitivity
Interventions: BIOLOGICAL: Tree MATA MPL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Cancer|Advanced Cancer|Locally Advanced Carcinoma|Metastatic Solid Tumor|Triple Negative Breast Cancer|Pancreas Cancer|Pancreatic Adenocarcinoma
Interventions: DRUG: AGX101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PhII One Label Non-Comparative Trial in Metastatic Hormone Refractory Prostate Cancer in Combination With Prednisolone
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: ARD6562, Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pink Warrior 2: Teleconference-based Gaming Support
Status: COMPLETED
Conditions: Breast Cancer|Physical Activity
Interventions: BEHAVIORAL: Active video game teleconference support group|BEHAVIORAL: Standard support group + pedometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Emergency Department Triage in a Resource Constrained Setting: Application of the World Health Organization Triage Scale in Regional Papua New Guinea
Status: UNKNOWN
Conditions: Emergencies
Interventions: OTHER: Introduction of the World Health Organization Triage Scale
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Use of Corticosteroids in Third Molar Surgery
Status: COMPLETED
Conditions: Inflammation|Pain, Postoperative|Trismus
Interventions: DRUG: Dexamethasone 4 Mg/mL Injectable Solution|DRUG: MethylPREDNISolone 40 Mg/mL Injectable Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Use of the Tip Stim Glove Device to Achieve Coordinated Movement of the Human Hand
Status: COMPLETED
Conditions: Stroke, Ischemic
Interventions: PROCEDURE: hand motor coordination in a sitting position after use TipStim Glove
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Norepinephrine Infusion Combined With Goal-directed Fluid Therapy in Patients Undergoing Kidney Transplantations
Status: RECRUITING
Conditions: Delayed Graft Function|End Stage Renal Disease|Kidney Transplantation
Interventions: DRUG: Goal-Directed Fluid Therapy (GDFT)|DRUG: Regular Fluid Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Biomarkers in Predicting Response to Rituximab Treatment in Samples From Patients With Indolent Follicular Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|GENETIC: DNA analysis|GENETIC: gene expression analysis|GENETIC: polymorphism analysis|OTHER: laboratory biomarker analysis|OTHER: medical chart review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Genome-Based Assessment of Niraparib (ZEJULA®) Efficacy in Advanced Solid TumorS With Homologous Recombination Deficiency
Status: NOT_YET_RECRUITING
Conditions: Efficacy
Interventions: DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1a Trial Assessing the Safety, Tolerability, and Immunogenicity of GS-4774 (GI-13020) at Various Dose Levels and Regimens in Healthy Adults
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: GS-4774
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Diet and 5ASA ( 5-aminosalicylic Acid) for Ulcerative Colitis
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: DIETARY_SUPPLEMENT: Group 1- Control Diet|DIETARY_SUPPLEMENT: Group 2- UCD Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Safety, Tolerability and Potential Therapeutic Effects of JNJ-40411813 in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: JNJ-40411813|DRUG: JNJ-40411813|DRUG: Placebo|DRUG: Antipsychotic medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalency Study of Montelukast Chewable 5 mg Tablets Under Fasted Conditions
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Montelukast|DRUG: Singulair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Zoledronic Acid in the Prevention of Cancer Therapy Induced Bone Loss
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Zoledronic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamics of Lorelin Depot (Leuprorelin Acetate - Bergamo) Compared to Lupron Depot ® (Leuprorelin Acetate - Abbot)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lorelin Depot Bergamo|DRUG: Lupron Depot - Abbott
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Frequencies of Umbilical Cord-mesenchymal Stem Cells Through Peripheral Vein in Patients With ESLD
Status: NOT_YET_RECRUITING
Conditions: End-Stage Liver DIsease
Interventions: BIOLOGICAL: umbilical cord-mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Efficacy of Artemisinin Combination Therapies for Treatment of Uncomplicated Malaria Infection in Children
Status: COMPLETED
Conditions: P. Falciparum Malaria
Interventions: DRUG: artemether-lumefantrine|DRUG: Dihydroartemisinin-piperaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Auricular Acupuncture in Elective Cesarean Section.
Status: COMPLETED
Conditions: Anxiety Reduction, Elective Cesarean Section
Interventions: DEVICE: Apply an auricular acupuncture protocol by stimulating specific points of the ear with needles inserted on adhesive tape (Pyonex®).|DEVICE: Apply a device having no real effect|PROCEDURE: Disinfection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hydroxychloroquine Versus Pioglitazone in Combination Treatment for Type 2 Diabetes Mellitus
Status: TERMINATED
Conditions: Diabetes Mellitus Type 2 With Hyperglycemia
Interventions: DRUG: Hydroxychloroquine|DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preloaded Combination Nicotine Replacement Therapy on Smoking Cessation of Adult Population in Kazakhstan
Status: NOT_YET_RECRUITING
Conditions: Smoking Cessation|Smoking, Cigarette|Smoking Behaviors
Interventions: DRUG: Nicotine patch, Nicotine gums|BEHAVIORAL: Brief Advice (5 A's & 5 R's)|DRUG: Nicotine Patch: Preloading for 4 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Strain-Counterstrain Treatment of Piriformis Pain
Status: RECRUITING
Conditions: Low Back Pain, Mechanical|Piriformis Syndrome|Somatic Dysfunction of Sacral Region (Finding)
Interventions: OTHER: Strain-Counterstrain treatment of piriformis muscle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Frequency Jet Ventilation for Percutaneous Interventional Radiology
Status: UNKNOWN
Conditions: Percutaneous Tumor Ablation
Interventions: PROCEDURE: Jet ventilation group|PROCEDURE: Standard ventilation group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Durvalumab and Oleclumab in Resectable PDAC
Status: RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: Durvalumab|DRUG: Oleclumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on 'The Use of Non-contrast Helical Computerized Tomogram in Predicting Treatment Outcomes of Upper Ureteric Stone by Extracorporeal Shock Wave Lithotripsy Using the Sonolith 4000+ Lithotripter'
Status: COMPLETED
Conditions: Ureteral Calculi
Interventions: PROCEDURE: Non-contrast helical computerized tomogram (NCHCT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety Study of KPT-330 (Selinexor) in Patients With Advanced or Metastatic Solid Tumor Cancer
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: Selinexor|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Add-on Ambrisentan Therapy to Background Phosphodiesterase Type-5 Inhibitor (PDE5i) Therapy in Pulmonary Arterial Hypertension (ATHENA-1)
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Ambrisentan|DRUG: Placebo|DRUG: Sildenafil|DRUG: Tadalafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Home Rehabilitation Using Smart Wearable Exercise and Electrical Stimulation Device After Anterior Cruciate Ligament Reconstruction
Status: TERMINATED
Conditions: Anterior Cruciate Ligament Reconstruction
Interventions: DEVICE: Wearable Device(exoRehab)|BEHAVIORAL: Home rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Cognitive Behavioral Therapy on Post-Traumatic Stress Symptoms in Nursing Students
Status: COMPLETED
Conditions: Trauma and Stressor Related Disorders
Interventions: OTHER: Cognitive Behavioral Therapy Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Coronary artery bypass grafting|PROCEDURE: Percutaneous coronary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy Testing of Collagen and Zhuyin Drinks
Status: COMPLETED
Conditions: Skin Condition
Interventions: DIETARY_SUPPLEMENT: Placebo drink|DIETARY_SUPPLEMENT: Collagen Cubilose Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: An Investigational Drug Study to Assess Weight Loss in Obese and Overweight Patients (0364-037)(TERMINATED)
Status: TERMINATED
Conditions: Obesity
Interventions: DRUG: taranabant|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Erector Spinae Plane Block and Pectoral Nerve Block for Acute and Chronic Pain in Mastectomies
Status: UNKNOWN
Conditions: Acute Pain|Chronic Pain|Mastectomy
Interventions: PROCEDURE: PECS II block|PROCEDURE: ESP block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of 5-Fluorouracil/Leucovorin/Oxaliplatin (FOLFOX) + Bevacizumab Versus 5-Fluorouracil/Leucovorin/Oxaliplatin/Irinotecan (FOLFOXIRI) + Bevacizumab as First Line Treatment of Patients With Metastatic Colorectal Cancer Not Previously Treated and With Three or More Circulating Tumoral Cells
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: modified FOLFOX6 + bevacizumab|DRUG: FOLFOXIRI + Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Javelin Parp Medley: Avelumab Plus Talazoparib In Locally Advanced Or Metastatic Solid Tumors
Status: TERMINATED
Conditions: Avelumab in Combination With Talazoparib Will be Investigated in Patients With Locally Advanced (Primary or Recurrent) or Metastatic Solid Tumors
Interventions: DRUG: Avelumab Phase 1b|DRUG: Talazoparib Phase 1b|DRUG: Avelumab Phase 2|DRUG: Talazoparib Phase 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Effect of Zinc Supplementation to Improve the Treatment Effect of Botulinum Toxin for Oculofacial Spasm
Status: UNKNOWN
Conditions: Blepharospasm|Hemifacial Spasm
Interventions: DRUG: Zinc Supplement|DRUG: Sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of New Different Herbal Mouthwashes Against Caries Forming Bacteria, RCT
Status: RECRUITING
Conditions: Dental Caries in Children
Interventions: DRUG: Moringa mouthwash|DRUG: star anise mouthwash|DRUG: Indian costus mouth wash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Outpatient vs. Inpatient Management of Low-risk Patients With Upper Gastrointestinal Bleeding.
Status: TERMINATED
Conditions: Upper Gastrointestinal Bleeding
Interventions: OTHER: Outpatient Management of Low-risk Patients|OTHER: Inpatient Management of Low-risk Patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: axSEND: Exploring Immune and Microbiota Effects of a Partial Enteral Nutrition Diet in Axial Spondyloarthritis
Status: RECRUITING
Conditions: Axial Spondyloarthritis|Ankylosing Spondylitis|Inflammation|Dysbiosis|Arthritis|Spondylitis|Spondylarthritis|SpA|AxSpA
Interventions: DIETARY_SUPPLEMENT: Partial enteral nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Understand the Effect of Tablet Formulation and Food on PF-06821497 in Healthy Adult Participants.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06821497 Treatment A|DRUG: PF-06821497 Treatment B|DRUG: PF-06821497 Treatment C|DRUG: PF-06821497 Treatment D|DRUG: PF-06821497 Treatment E|DRUG: PF-06821497 Treatment F
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Osteocentral Versus Locoregional Anesthesia in Case of Mandibular Molar Pulpitis
Status: COMPLETED
Conditions: Endodontic Inflammation
Interventions: DEVICE: computerized intraosseous technique (Quicksleeper™)|DEVICE: loco-regional anesthesia (IANB technique)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of EXPAREL for Prolonged Postsurgical Analgesia in Subjects Undergoing Third Molar Extraction
Status: COMPLETED
Conditions: Dental Pain
Interventions: DRUG: Bupivacaine liposome|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nitrous Oxide Prior to Intranasal Midazolam for Moderate Dental Sedation in Pediatric Patients
Status: UNKNOWN
Conditions: Dental Anxiety|Pain
Interventions: DRUG: Nitrous Oxide|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation Of Exercise-Induced Cardiac Conduction Instability In Predicting Ventricular Fibrillation Events In Hypertrophic Cardiomyopathy
Status: RECRUITING
Conditions: Hypertrophic Cardiomyopathy
Interventions: DIAGNOSTIC_TEST: Non-invasive ECG imaging - CardioInsight test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prevention of Contrast Induced Nephropathy With Sodium Bicarbonate
Status: UNKNOWN
Conditions: Contrast Induced Nephropathy
Interventions: DRUG: 3 amps of sodium bicarbonate mixed in one liter of D5W
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Proof of Concept Study To Evaluate the Efficacy and Justification Of OBV/PTV/r and DSV In Adults With Chronic Hepatitis C Virus Genotype 2K/1B
Status: COMPLETED
Conditions: HCV Coinfection
Interventions: DRUG: VEKIRAX|DRUG: EXVIERA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GVHD Prophylaxis by Addition of CD20 Monoclonal Antibody to the Conditioning Regimen in SAA With Treatment of Allo-HSCT
Status: RECRUITING
Conditions: Aplastic Anemia
Interventions: DRUG: CD20 monoclonal antibody|DRUG: ATG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chidamide + R-GemOx Regimen as Salvage Treatment for Transplant-ineligible Patients With Relapsed/Refractory DLBCL
Status: COMPLETED
Conditions: Lymphoma, Large B-Cell, Diffuse
Interventions: DRUG: Chidamide, Rituximab, Gemcitabine,Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Bempegaldesleukin (BEMPEG: NKTR-214) Combined With Nivolumab and Tyrosine Kinase Inhibitor (TKI) to Nivolumab and TKI Alone in Participants With Previously Untreated Kidney Cancer That is Advanced or Has Spread
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: BIOLOGICAL: Nivolumab|DRUG: Axitinib|DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Binimetinib and Hydroxychloroquine in Treating Patients With KRAS Mutant Metastatic Pancreatic Cancer
Status: RECRUITING
Conditions: Metastatic Pancreatic Adenocarcinoma|Stage IV Pancreatic Cancer AJCC v8
Interventions: DRUG: Binimetinib|DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy Cisplatin With or Without Fluorouracil Patients With Stage III or Stage IV Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: cisplatin|DRUG: fluorouracil|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D and Calcium Supplementation at Danish Nursing Homes
Status: COMPLETED
Conditions: Frailty|Physical Disability|Aging|Muscle Weakness
Interventions: DIETARY_SUPPLEMENT: Vitamin D and calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Zoledronic Acid Treatment (Every 4 or 12 Weeks) to Prevent Skeletal Complications in Advanced Multiple Myeloma Participants
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination of Nebivolol and Valsartan Given as Free Tablets for Stage 1 or Stage 2 Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Nebivolol, Valsartan and Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study to Treat Patients With Soft Tissue Sarcomas
Status: COMPLETED
Conditions: Metastatic, Locally Advanced or Unresectable Soft Tissue Sarcoma
Interventions: DRUG: Aldoxorubicin|DRUG: Investigator's Choice Treatment (Darcabazine, Pazopanib, Gemcitabine + Docetaxel, Doxorubicin, Ifosfamide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HOme Vision Monitoring in AREDS2 for Progression to Neovascular AMD Using the ForeseeHome Device
Status: COMPLETED
Conditions: Age Related Macular Degeneration
Interventions: DIAGNOSTIC_TEST: ForeseeHome AMD Monitoring Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Reboxetine for Sleep Apnoea After ENT Surgery
Status: NOT_YET_RECRUITING
Conditions: Sleep Apnea, Obstructive
Interventions: DRUG: Reboxetine 4 MG Oral Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety of Tobramycin Inhalation Powder (TIP) vs Tobramycin Solution for Inhalation in Patients With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Tobramycin Inhalation Powder|DRUG: Tobramycin Solution for Inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intravenous Lidocaine on Postoperative Cognitive Function in Elderly Patients
Status: NOT_YET_RECRUITING
Conditions: Organ Protection
Interventions: DRUG: Lidocaine|OTHER: Normal saline (NS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Trial of Computer-based Attention-training Systems in Children With Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: Computer attention training systems for children with ADHD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: |Primary Purpose: TREATMENT
Clinical trial: Multicenter Study to Describe the Performance of the AOS-C2001-B Device in Patients With Colostomy
Status: COMPLETED
Conditions: Colostomy Stoma
Interventions: DEVICE: AOS-C2001-B
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Influence of Platform-switching on Bone Level Alterations: a 3 Year Randomized Clinical Trial (RCT).
Status: COMPLETED
Conditions: Periimplant Crestal Bone Level Changes
Interventions: DEVICE: platform-shifted implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Leuprolide, Bicalutamide, and Implant Radiation Therapy in Treating Patients With Locally Recurrent Prostate Cancer After External-Beam Radiation Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: bicalutamide|DRUG: leuprolide acetate|PROCEDURE: adjuvant therapy|PROCEDURE: neoadjuvant therapy|PROCEDURE: quality-of-life assessment|RADIATION: brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Microstructure of Ingestive Behavior and Body Weight Loss After Roux-en-Y Gastric Bypass
Status: COMPLETED
Conditions: Obesity|Food Deprivation|Bariatric Surgery|Roux-en-y Gastric Bypass|Ingestive Microstructure|Ingestive Behavior|Drinkometer
Interventions: PROCEDURE: Roux-en-Y Gastric Bypass
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cisplatin With or Without Veliparib in Treating Patients With Recurrent or Metastatic Triple-Negative and/or BRCA Mutation-Associated Breast Cancer With or Without Brain Metastases
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic BRCA Hereditary Breast Carcinoma|Metastatic Breast Carcinoma|Metastatic Malignant Neoplasm in the Brain|Metastatic Triple-Negative Breast Carcinoma|Recurrent Breast Carcinoma|Stage IV Breast Cancer AJCC v6 and v7
Interventions: DRUG: Cisplatin|OTHER: Laboratory Biomarker Analysis|OTHER: Placebo Administration|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate JNJ-64565111 Pharmacokinetics and Safety in Adult Participants With Varying Degrees of Renal Function
Status: COMPLETED
Conditions: Kidney Failure, Chronic
Interventions: DRUG: JNJ-64565111
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Improving Care for Children With Complex Needs
Status: COMPLETED
Conditions: Medically Complex Children|Care Coordination|Case Manager|Care Manager|Collaborative Care|Disease Management|Patient Care Team or Organization|Managed Care|Children With Chronic Conditions|Children With Special Health Care Needs|Shared Care Plan|Patient Care Plan|Health Care and Resource Utilization|Adherence to Care|Functional Status and Productivity|Health Related Quality of Life|Satisfaction With Care|Care Coordinator|Family Experience of Care|Quality Health Care
Interventions: BEHAVIORAL: Comprehensive Case Management Service
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Allogeneic Cord Blood Cells for Adults With Severe Acute Contusion Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Contusion
Interventions: BIOLOGICAL: Human Allogeneic Umbilical Cord Blood Mononuclear Cells (hUCBMCs) systemic (i.v.) infusions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of a Single IVT Injection of QPI-1007 in Chronic Optic Nerve Atrophy and Recent Onset NAION Patients
Status: COMPLETED
Conditions: Optic Atrophy|Non-arteritic Anterior Ischemic Optic Neuropathy
Interventions: DRUG: QPI-1007 at various doses
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: MEDI4736 With Selumetinib for KRAS Mutant Non-Small Cell Lung Cancer (NSCLC)
Status: WITHDRAWN
Conditions: Malignant Neoplasm of Respiratory and Intrathoracic Organ Carcinoma|Advanced Lung Cancer|Recurrent Nonsmall Cell Lung Cancer
Interventions: DRUG: Selumetinib|DRUG: Durvalumab|BEHAVIORAL: Phone Calls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telmisartan, Amlodipine and Flow Mediated Dilation
Status: UNKNOWN
Conditions: Hypertension
Interventions: DRUG: Telmisartan|DRUG: Amlodipine|DRUG: Olmesartan medoxomil|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of a New Formulation of Chondroitin Sulfate and Glucosamine Sulfate to Treat Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: CS+SG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT