pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparing The Effectiveness Of Pericapsular Nerve Group (PENG) Block Versus Supra-Inguinal Fascia Iliaca Compartment Block(S-FICB) In Reducing Positional Pain During Neuraxial Anaesthesia In Hip Fractures Patients
Status: RECRUITING
Conditions: Hip Fractures
Interventions: PROCEDURE: Pericapsular nerve group (PENG) block|PROCEDURE: Supra-inguinal fascia iliaca compartment (S-FICB) block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A follow-on Safety Study of CDP870 in Subjects With Crohn's Disease (CD) Who Have Completed a 26-week Double Blind Study CDP870-031 [NCT00152490] or CDP870-032 [NCT00152425]
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: Certolizumab Pegol (CDP870)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Early Reperfusion With Adjuvant Dornase Alfa in Large Vessel Ischemic Stroke (EXTEND-IA DNase)
Status: RECRUITING
Conditions: Ischemic Stroke
Interventions: DRUG: Dornase Alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of TTFields (150kHz) in Non-small Cell Lung Cancer (NSCLC) Patients With 1-5 Brain Metastases Following Optimal Standard Local Treatment (COMET)
Status: UNKNOWN
Conditions: 1-5 Brain Metastases From Non-Small Cell Lung Cancer
Interventions: DEVICE: NovoTTF-100A device|OTHER: Best Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CHP 834 Unrelated and Partially Matched Related Donor Peripheral Stem Cell Transportation for T and B Cell Depletion
Status: COMPLETED
Conditions: Immunodeficiencies
Interventions: DEVICE: CliniMACs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobilization With Movement Versus Soft Tissue Mobilization in Patients With De Quervain Tenosynovitis
Status: UNKNOWN
Conditions: De Quervain Syndrome
Interventions: OTHER: Mulligan Mobilization|OTHER: Soft Tissue Mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction Therapy With Cytarabine, High-Dose Mitoxantrone and Dasatinib for Patients With Philadelphia-Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Leukemia|Acute Lymphoblastic Leukemia
Interventions: DRUG: Dasatinib, Mitoxantrone, Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Topical Rapamycin Associated With Pulsed Dye Laser in Patients With Sturge-Weber Syndrome
Status: COMPLETED
Conditions: Sturge- Weber Syndrome
Interventions: DRUG: Drug: Topical Rapamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Radial Versus Femoral Secondary Access During TAVI
Status: TERMINATED
Conditions: Aortic Stenosis|Aortic Valve Disease|Vascular Access Complication
Interventions: PROCEDURE: Secondary Radial Artery Access|PROCEDURE: Secondary Femoral Artery Access
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azacitidine in Treating Patients With Previously Treated Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Recurrent Lung Non-Small Cell Carcinoma|Stage IV Lung Non-Small Cell Cancer AJCC v7
Interventions: DRUG: Azacitidine|OTHER: Diagnostic Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cinnamon and COH in PCOS Women Underdoing IVF/ICSI Cycles
Status: RECRUITING
Conditions: Polycystic Ovary Syndrome
Interventions: DIETARY_SUPPLEMENT: Oral cinnamon supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pembrolizumab Plus Lenvatinib in Previously Treated Classic Kaposi Sarcoma
Status: NOT_YET_RECRUITING
Conditions: Kaposi Sarcoma|Classic Kaposi Sarcoma|Refractory Kaposi Sarcoma
Interventions: DRUG: Pembrolizumab + Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Radiographic Evaluation of Two Matrix Systems for Restoration of Class II Cavities in Primary Molars
Status: NOT_YET_RECRUITING
Conditions: Tooth Decay|Tooth Restoration
Interventions: DEVICE: Fender Mate matrix system|DEVICE: T-band matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Interactive Voice Response System (IVRS) for Managing Symptoms of Patients Following Thoracic Surgery
Status: COMPLETED
Conditions: Esophageal Cancer|Lung Cancer
Interventions: BEHAVIORAL: Interactive Voice Response System|OTHER: Symptoms Report
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Propofol or Midazolam for Sedation and Early Extubation Following Coronary Artery Bypass Graft Surgery
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Kentucky Women's Justice Community Opioid Innovation Network
Status: ACTIVE_NOT_RECRUITING
Conditions: Opioid-use Disorder
Interventions: BEHAVIORAL: MOUD Pre-Treatment Telehealth|BEHAVIORAL: MOUD Pre-Treatment Telehealth and Peer Navigator|OTHER: Services as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Measurement-based Care in Patients With Depressive Disorder: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Paroxetine|DRUG: Mirtazapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pivotal Study to Evaluate Safety and Immunogenicity of a Live-Attenuated Chikungunya Virus Vaccine Candidate in Adults
Status: COMPLETED
Conditions: Chikungunya Virus Infection
Interventions: BIOLOGICAL: VLA1553|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Low Molecular Weight hEparin vs. Aspirin Post-partum
Status: RECRUITING
Conditions: Venous Thromboembolism
Interventions: DRUG: Prophylactic low molecular weight heparin|DRUG: Low molecular weight heparin and low-dose aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Timing of Oocyte Denudation Before ICSI in an Oocyte Donation Model
Status: COMPLETED
Conditions: Fertility
Interventions: PROCEDURE: timing for oocyte denudation and Intracytoplasmatic Sperm injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 2 Study to Evaluate Pharmacokinetics, Safety and Efficacy of TMC114/Ritonavir (Rtv) in Human Immunodeficiency Virus (HIV)-1 Infected Children and Adolescents
Status: COMPLETED
Conditions: HIV-1|HIV Infections
Interventions: DRUG: TMC114|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of SIMEOX on Airway Clearance in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: OTHER: Autogenic drainage|DEVICE: SIMEOX + Autogenic drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bacille Calmette-Guérin (BCG) Vaccine In Radiologically Isolated Syndrome (RIS)
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: DRUG: Bacille Calmette-Guerin vaccine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing 25d ProCor Needle Versus the Standard 25g Needle for Biopsies Performed by EUS-FNA
Status: COMPLETED
Conditions: Solid Lesion Biopsies
Interventions: DEVICE: 25g standard needle|DEVICE: 25d ProCor needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Ofatumumab Subcutaneous Administration in Subjects With Relapsing-Remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Ofatumumab 3mg|DRUG: Ofatumumab 30mg|DRUG: Ofatumumab 60mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing the Effects of Aging on Cognition With Therapeutic Intervention of an Oral Nutrient (REACTION): A Pilot Trial
Status: COMPLETED
Conditions: Cognitive Decline
Interventions: DRUG: Souvenaid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease
Status: RECRUITING
Conditions: Psychosis Associated With Alzheimer's Disease
Interventions: DRUG: KarXT|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sequential and Mixture Injection of Opioids and Hyperbaric Bupivacaine
Status: COMPLETED
Conditions: Bupivacaine Adverse Reaction|Regional Anesthesia Morbidity|Cesarean Section Complications
Interventions: DRUG: Bupivacaine-fentanyl-Morphine.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Slit Face Trial Using Micro-injections of Transparent Hyaluronic Acid Gel for Rejuvenation of the Cheek
Status: UNKNOWN
Conditions: Problem of Aging
Interventions: DEVICE: Hyaluronic Acid filler|OTHER: Sham Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Scleroderma Patient-centered Intervention Network (SPIN) Hand Program Feasibility Study
Status: COMPLETED
Conditions: Scleroderma|Systemic Sclerosis
Interventions: OTHER: SPIN-HAND program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Zoledronic Acid and Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Osteosarcoma
Status: COMPLETED
Conditions: Sarcoma
Interventions: DRUG: cisplatin|DRUG: dexrazoxane hydrochloride|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: leucovorin calcium|DRUG: methotrexate|DRUG: zoledronic acid|PROCEDURE: adjuvant therapy|PROCEDURE: neoadjuvant therapy|PROCEDURE: therapeutic conventional surgery|BIOLOGICAL: filgrastim|DRUG: Mesna
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Combined Thread Embedding Acupuncture With Auricular Acupuncture for GERD
Status: COMPLETED
Conditions: GERD
Interventions: OTHER: Thread Embedding Acupuncture|OTHER: Auricular acupuncture|OTHER: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Psoriasis Plaque Test Comparing Products for the Treatment of Psoriasis Vulgaris
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: Combination of clobetasol propionate plus calcipotriol ointment, clobetasol propionate ointment, calcipotriol ointment, and the ointment vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of the Techniques for Intrathoracic Esophagogastric Anastomosis on Outcome in Ivor-Lewis Oesophagectomy
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: PROCEDURE: side-to-side stapled esophagogastric anastomosis|PROCEDURE: circular-stapled esophagogastric anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Metabolic and Cardiovascular Effects of Renal Denervation
Status: TERMINATED
Conditions: Insulin Resistance|Hypertension
Interventions: PROCEDURE: Renal denervation using Medtronic Symplicity System (mono-electrode)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Heat Exposure on Cognition in Persons With Tetraplegia
Status: COMPLETED
Conditions: Tetraplegia|Hypothermia|Mild Cognitive Impairment
Interventions: PROCEDURE: Warm Temperature
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparing the Outcomes of Incisions Made by Colorado® Microdissection Needle
Status: COMPLETED
Conditions: Periodontitis
Interventions: DEVICE: Colorado® microdissection needle|DEVICE: Cautery tip|DEVICE: BP blade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Leg Cycling Exercise Program at Low or Moderate Intensity for Individuals With Subacute Stroke
Status: UNKNOWN
Conditions: Stroke
Interventions: OTHER: the low-intensity exercise group|OTHER: the moderate-intensity exercise group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of a Locally Produced RUTF With a Commercial RUTF in the Treatment of SAM
Status: UNKNOWN
Conditions: Malnutrition|Children|Treatment
Interventions: DIETARY_SUPPLEMENT: 2 months of treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Efficacy of Topical Roflumilast Cream in the Treatment of Facial Papulopustular Rosacea
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: Roflumilast Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Cetuximab and Trifluridin Tipiracil as the Third-line Therapy in the RASwt mCRC
Status: UNKNOWN
Conditions: Colorectal Neoplasms Malignant
Interventions: DRUG: Cetuximab + trifluridin tipiracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Modified-Otago and Tai Chi Exercises in Patients With Stroke
Status: RECRUITING
Conditions: Stroke
Interventions: OTHER: Modified-Otago Exercises|OTHER: Tai-Chi Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Trapezius MSAT on Acute Whiplash Injury
Status: COMPLETED
Conditions: Whiplash Injury of Cervical Spine|Neck Pain, Posterior
Interventions: PROCEDURE: trapezuis motion style acupuncture treatment|PROCEDURE: other Korean medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Desflurane and Sevoflurane on Remifentanil Requirement
Status: NOT_YET_RECRUITING
Conditions: Spinal Diseases
Interventions: DRUG: Desflurane Inhalation Solution|DRUG: Sevoflurane Inhalation Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I-II Study of Intratumoral Urelumab Combined With Nivolumab in Patients With Solid Tumors
Status: UNKNOWN
Conditions: Neoplasms
Interventions: DRUG: Urelumab + Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zenith(R) Low Profile AAA Endovascular Graft Clinical Study
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysms|Iliac Aneurysms|Aorto-iliac Aneurysms
Interventions: DEVICE: Zenith(R) Low Profile AAA Endovascular Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study of AOC 1020 in Adults With Facioscapulohumeral Muscular Dystrophy (FSHD)
Status: RECRUITING
Conditions: FSHD|FSHD1|FSHD2|FMD|FMD2|Fascioscapulohumeral Muscular Dystrophy|Fascioscapulohumeral Muscular Dystrophy Type 1|Fascioscapulohumeral Muscular Dystrophy Type 2|Dystrophies, Facioscapulohumeral Muscular|Dystrophy, Facioscapulohumeral Muscular|Facioscapulohumeral Muscular Dystrophy 1|Facioscapulohumeral Muscular Dystrophy 2|Facio-Scapulo-Humeral Dystrophy|Atrophy, Facioscapulohumeral|Atrophies, Facioscapulohumeral|Facioscapulohumeral Atrophy|Muscular Dystrophies|Muscular Dystrophy, Facioscapulohumeral|FSH Muscular Dystrophy|Landouzy Dejerine Dystrophy|Landouzy-Dejerine Muscular Dystrophy|Dystrophies, Landouzy-Dejerine|Dystrophy, Landouzy-Dejerine|Landouzy-Dejerine Syndrome|Muscular Dystrophy, Landouzy Dejerine|Progressive Muscular Dystrophy|FSH
Interventions: DRUG: AOC 1020|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Response to Anti-hypertensives in Pregnant and Postpartum Patients
Status: COMPLETED
Conditions: Hypertension in Pregnancy|Preeclampsia
Interventions: DRUG: Nifedipine|DRUG: Labetalol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Myotomy of the Pylorus To Improve Emptying and Symptoms Trial
Status: RECRUITING
Conditions: Gastroparesis
Interventions: PROCEDURE: Endoscopic per-oral pyloromyotomy (POP)|PROCEDURE: Diagnostic esophagogastroduodenoscopy (EGD) without pyloric disruption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise to Improve Brain Health in Older African Americans
Status: RECRUITING
Conditions: Aging|Alzheimer Disease|Healthy Aging|Cognitive Change
Interventions: BEHAVIORAL: Cardio-Dance Fitness|BEHAVIORAL: Strength, Flexibility & Balance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Neuroprotective Effect of Dexmedetomidine Preserving Brain Functional Connectivity in Elderly Patients
Status: RECRUITING
Conditions: Anesthesia|Dexmedetomidine|Aging
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation
Status: COMPLETED
Conditions: Cervical Disc Herniation|Cervical Spinal Stenosis|Cervical Spine Damage
Interventions: DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Efficacy of Insulin Like Growth Factor-1(IGF-1) on Bone Regeneration in Intrabony Defects : A Clinico-radiograph Study
Status: RECRUITING
Conditions: Intrabony Periodontal Defect
Interventions: PROCEDURE: IGF-1 Gel|PROCEDURE: Hydroxyapatite
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acetaminophen or Fluvastatin Compared to Placebo on the Transient Post-Dose Symptoms (PDS) Following an Intravenous (i.v.) Infusion of a Single Dose of Zoledronic Acid 5mg, in Post-menopausal Women With Low Bone Mass
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Placebo|DRUG: Acetaminophen|DRUG: Fluvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bariatric Surgery Evaluation and Assessment of Treatment Efficacy - Intervention Trial
Status: NOT_YET_RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction|Atrial Fibrillation
Interventions: PROCEDURE: Bariatric surgery strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Surgery Versus Primary Chemotherapy in Resectable Signet Ring Cell Gastric Adenocarcinoma
Status: RECRUITING
Conditions: Signet Ring Cell Gastric Adenocarcinoma
Interventions: PROCEDURE: peri-operative chemotherapy|PROCEDURE: Surgery first
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Safety of BAY1817080, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug in Participants With Impaired Liver Function or Normal Liver Function
Status: COMPLETED
Conditions: Endometriosis Related Pain|Overactive Bladder|Diabetic Neuropathic Pain|Refractory or Unexplained Chronic Cough
Interventions: DRUG: BAY1817080|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of SHR-1222 on Vascular Inflammatory Factors in Patients With Low Bone Mass
Status: COMPLETED
Conditions: Osteoporosis, Osteopenia
Interventions: DRUG: SHR-1222|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exparel vs Block for ACL Reconstruction
Status: ENROLLING_BY_INVITATION
Conditions: ACL|Postoperative Pain
Interventions: DRUG: Exparel 30 mL|DRUG: 0.5% bupivacaine|DRUG: Dexamethasone|DRUG: iPACK block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability And Mechanism Of Action Of Boswellic Acids (BA) In Multiple Sclerosis (SABA)
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: Boswellic acids (BOSWELAN)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Plasma Doravirine Once Daily Over 72 Hours Following Drug Intake Cessation in Healthy Volunteers
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: Doravirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of an Eccentric Exercise Program on Quality of Life and Function in People With Chronic Heart Failure.
Status: COMPLETED
Conditions: Chronic Heart Failure
Interventions: OTHER: walking and light weights|OTHER: eccentric aerobic exercise|OTHER: concentric aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of R-hLH (Luveris ®) Priming Prior to R-HFSH Treatment in Infertile Women Undergoing IVF-ET
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: recombinant human LH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Supervised Exercise Program in Subacromial Impingement Syndrome
Status: COMPLETED
Conditions: Subacromial Impingement Syndrome
Interventions: DRUG: Subacromial-subdeltoid bursa corticosteroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarker Verification in Pediatric Chronic GvHD: ABLE 2.0 / PTCTC GVH 1901 Study
Status: RECRUITING
Conditions: Chronic Graft-versus-Host-Disease|Leukemia|Allogeneic Hematopoietic Stem Cell Transplantation|Blood Cancer|Non-Malignant Hematologic and Lymphocytic Disorder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tailored Neoadjuvant Chemotherapy for Stage II/III Breast Cancer With Tumor Size More Than 2 cm
Status: COMPLETED
Conditions: Breast Cancer|Chemotherapy
Interventions: DRUG: Taxotere , Epirubicin|DRUG: E-HDFL,EP,TE,N-HDFL,NP,T-HDFL,TP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Duloxetine for Chronic Depression: a Double-blind Study
Status: COMPLETED
Conditions: Dysthymic Disorder|Depressive Disorder NOS
Interventions: DRUG: Duloxetine (Cymbalta)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of BIIB022 (Anti-IGF-1R Monoclonal Antibody) in Relapsed/Refractory Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: BIIB022
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venetoclax, SL-401, and Chemotherapy for the Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm
Status: RECRUITING
Conditions: Blastic Plasmacytoid Dendritic Cell Neoplasm
Interventions: DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Dexamethasone|DRUG: Doxorubicin|DRUG: Mercaptopurine|DRUG: Methotrexate|DRUG: Methylprednisolone|DRUG: Prednisone|BIOLOGICAL: Rituximab|BIOLOGICAL: Tagraxofusp-erzs|DRUG: Venetoclax|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fermented Iron-rich Supplement in Reducing Anemia
Status: UNKNOWN
Conditions: Iron Deficiency Anemia
Interventions: DIETARY_SUPPLEMENT: supplement containing 60 mg iron sulfate|DIETARY_SUPPLEMENT: iron rich food supplement (60 mg iron)|DIETARY_SUPPLEMENT: iron rich food supplement (10 mg iron)|DIETARY_SUPPLEMENT: supplement containing 10 mg iron sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Afatinib and Cetuximab in Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Positive Non-small-cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Afatinib|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of AQUAVAN® Injection (AQUAVAN; Fospropofol Disodium) for Sedation During Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy|Colonic Polyps
Interventions: DRUG: AQUAVAN® (fospropofol disodium) Injection|DRUG: Midazolam HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of 2-Iminobiotin in Neonates With Perinatal Asphyxia
Status: TERMINATED
Conditions: Perinatal Asphyxia
Interventions: DRUG: 2-Iminobiotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Alirocumab in Participants With Autosomal Dominant Hypercholesterolemia (ADH) and Gain-of-Function Mutations (GOFm) of the Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Gene or Loss-of-Function Mutations (LOFm) of the Apolipoprotein (Apo) B Gene
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Alirocumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Baby Dolls for Teaching Newborn Positioning and Attachment
Status: COMPLETED
Conditions: Breastfeeding|Patient Simulation|High Fidelity Simulation Training
Interventions: OTHER: Positioning and Attachment video-based simulation (telesimulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Reliability of All on 4 Using 2 Zygomatic and 2 Conventional Implants vs All on 4 Implants for Rehabilitation of Maxilla
Status: UNKNOWN
Conditions: Edentulous; Alveolar Process, Atrophy
Interventions: PROCEDURE: zygomatic implant|PROCEDURE: conventional implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment With Zoledronic Acid in Patients With Breast Cancer, Multiple Myeloma, and Prostate Cancer With Cancer Related Bone Lesions
Status: COMPLETED
Conditions: Breast Cancer|Multiple Myeloma|Prostate Cancer
Interventions: DRUG: zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Desmopressin as Treatment for Postoperative Bleeding After Cardiac Surgery
Status: TERMINATED
Conditions: Hemorrhage|Postoperative Blood Loss
Interventions: DRUG: Desmopressin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Octreotide (MYCAPSSA™ [Formerly Octreolin™]) for Acromegaly
Status: COMPLETED
Conditions: Acromegaly
Interventions: DRUG: Octreotide capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dupilumab in Allergic Fungal Rhinosinusitis (AFRS) (LIBERTY-AFRS-AI)
Status: ACTIVE_NOT_RECRUITING
Conditions: Allergic Fungal Rhinosinusitis
Interventions: DRUG: Dupilumab SAR231893|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Streptococcus Salivarius K12 for Prevention and Treatment of Oral Mucositis in Patients Undergoing Radiotherapy
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Streptococcus salivarius K12|DRUG: Streptococcus salivarius K12 simulants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Hand Massage on Endotracheal Suctioning Pain and Hemodynamic Parameters
Status: COMPLETED
Conditions: Endotracheal Aspiration|Pain|Reflexology|Massage|Hemodynamic Instability
Interventions: OTHER: reflexology hand massage|OTHER: classical hand massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial of the Safety and Efficacy of SP160412 in the Temporary Relief of Mild to Moderate Sunburn
Status: TERMINATED
Conditions: Sunburn
Interventions: DRUG: SP160412 Ibuprofen 400 mg and Chlorpheniramine maleate 4 mg|DRUG: 2 capsules Ibuprofen and 1 placebo|DRUG: capsule Chlorpheniramine 4mg and 1 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Bacterial Conjunctivitis With SHP640 Compared to PVP-Iodine and Placebo
Status: COMPLETED
Conditions: Bacterial Conjunctivitis
Interventions: DRUG: SHP640|DRUG: PVP-I 0.6%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety &Efficacy of CF101 to Subjects With Uveitis
Status: WITHDRAWN
Conditions: Uveitis, Posterior|Uveitis, Intermediate
Interventions: DRUG: CF101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Synthetic Cranioplasty PEEK Versus UHMWP
Status: COMPLETED
Conditions: Cranium; Deformity
Interventions: DEVICE: UHMWP Cranioplasty|DEVICE: PEEK Cranioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial Assessing the Efficacy of Immuno-Radiation Abscopal Effect in Patients With Metastatic Cancers
Status: WITHDRAWN
Conditions: Metastatic Breast Cancer|Metastatic Colorectal Cancer|Metastatic Head and Neck Cancer
Interventions: RADIATION: Systemic treatment + Stereotactic Body Radio-Therapy (SBRT)|OTHER: Systemic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fentanyl Transdermal Patch With CHADD™ for Breakthrough Pain in Patients With Moderate to Severe Non-Malignant Pain
Status: TERMINATED
Conditions: Pain
Interventions: DRUG: Matrix Transdermal Fentanyl/CHADD Drug Delivery System|DRUG: Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bipolar Enbloc Versus Thulium-Yag Enbloc Resection of Bladder Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Bladder Cancer
Interventions: PROCEDURE: Bipolar enbloc resection of bladder tumor|PROCEDURE: Thulium laser enbloc resection of bladder tumor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Hyperbaric Oxygen Treatment in Trigeminal Neuralgia Patients
Status: UNKNOWN
Conditions: Trigeminal Neuralgia|Pain
Interventions: PROCEDURE: Hyperbaric oxygen, Mock hyperbaric chamber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Efficacy of Dexmedetomidine Added to Fentanyl in PCEA
Status: COMPLETED
Conditions: Abdominal Pain|Abdominal Cancer
Interventions: PROCEDURE: TEA+DEX|PROCEDURE: TEA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Development and Piloting of a Just-in-Time, Personalized HIV Prevention Intervention for Youth Experiencing Homelessness and Unstable Housing
Status: COMPLETED
Conditions: Behavior, Risk
Interventions: BEHAVIORAL: HIV|BEHAVIORAL: General health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Metformin, Muscle Energetics, and Vascular Function in Older Adults With Peripheral Artery Disease
Status: TERMINATED
Conditions: Peripheral Artery Disease
Interventions: DRUG: Metformin 1000 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ring Versus Suture Annuloplasty For Functional Tricuspid Regurgitation In Rheumatic Mitral Valve Diseases
Status: UNKNOWN
Conditions: Functional Tricuspid Regurgitation
Interventions: PROCEDURE: Tricuspid Annuloplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Prevention of Sexually Transmitted Infections (STIs) in Men Who Have Sex With Men and Using Oral Tenofovir Disoproxil Fumarate/ Emtricitabine (TDF/FTC) for HIV Pre-Exposure Prophylaxis (PrEP)
Status: COMPLETED
Conditions: Unsafe Sex|Risk-Taking
Interventions: DRUG: Experimental: doxycycline|BIOLOGICAL: Bexsero® vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Study Adding Niraparib and Dostarlimab to Radiation Therapy for Rectal Cancers
Status: SUSPENDED
Conditions: Rectal Neoplasms|Rectal Neoplasm Malignant
Interventions: DRUG: Niraparib|DRUG: Dostarlimab|RADIATION: Short course radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitreous Surgery With Intraocular Assistance
Status: TERMINATED
Conditions: Traction Retinal Detachments|Rhegmatogenous Retinal Detachments|Dislocated Intraocular Lens
Interventions: PROCEDURE: Intraocular assistance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Frequency and Duration of Breaks in Sitting Time on Metabolic Cardiovascular Risk Factors
Status: COMPLETED
Conditions: Sedentary Lifestyle|Overweight and Obesity|Metabolic Disease
Interventions: BEHAVIORAL: Control|BEHAVIORAL: Breaker|BEHAVIORAL: Prolonger|BEHAVIORAL: Intermediate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Impact of Nasogastric Indwelling Versus Oral Intermittent Tube Feeding Methods on Premature Infants
Status: COMPLETED
Conditions: Premature Infants
Interventions: PROCEDURE: Indwelling nasogastric tube placement|PROCEDURE: Intermittent orogastric tube placement|DEVICE: Nasogastric tube|DEVICE: Oral gastric tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neoadjuvant Immunotherapy for Stage III Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer Stage III
Interventions: DRUG: Sintilimab|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Web-based Support During Pregnancy and Early Motherhood in Women With Type 1 Diabetes (MODIAB-web)
Status: COMPLETED
Conditions: Diabetes Type 1|Pregnancy|Early Motherhood
Interventions: OTHER: web-based support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fresh Truck Pilot to Reduce Food Insecurity in a Medicaid ACO
Status: WITHDRAWN
Conditions: Food Insecurity
Interventions: OTHER: Fresh Truck with stipend|OTHER: THRIVE screening and referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Safety and Immunogenicity of Co-administering HPV Vaccine With Other Vaccines in Healthy Female Subjects
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: BIOLOGICAL: Different formulations of GSK Biologicals' HPV vaccine (580299)|BIOLOGICAL: Menactra TM|BIOLOGICAL: Boostrix TM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Capecitabine (Xeloda) and Radiation for Patients With Rectosigmoid Carcinoma
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: Capecitabine (Xeloda)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study in Adult Patients With Advanced Solid Malignancies
Status: COMPLETED
Conditions: Advanced Solid Tumors With Alterations of FGFR1, 2 and or 3|Squamous Lung Cancer With FGFR1 Amplification|Bladder Cancer With FGFR3 Mutation or Fusion|Advanced Solid Tumors With FGFR1 Amplication|Advanced Solid Tumors With FGFR2 Amplication|Advanced Solid Tumors With FGFR3 Mutation
Interventions: DRUG: BGJ398
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Computerized Cognitive Training for Diabetic Elderly Veterans
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: computerized cognitive training|OTHER: control games
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Hospital Fit on Physical Activity of Hospitalised Patients
Status: COMPLETED
Conditions: Cardiovascular Diseases|Oncology|Activation, Patient
Interventions: DEVICE: Hospital Fit 2.0, HFITAPP0, release 05, Maastricht Instruments B.V., the Netherlands
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quetiapine Fumarate (SEROQUEL) Compared to Placebo in the Treatment of Adolescent Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: quetiapine fumarate tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Subthreshold Laser Treatment in Intermediate Age-related Macular Degeneration With Nascent Geographic Atrophy Study
Status: RECRUITING
Conditions: Age-Related Macular Degeneration
Interventions: DEVICE: 2RT subthreshold nanosecond laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Pharmacokinetics and Potential Drug Interactions of a Fixed-dose Combination Tablet, HL-040XC, in Healthy Male Subjects
Status: COMPLETED
Conditions: Hypertension|Hyperlipidemia
Interventions: DRUG: HL040XC|DRUG: Losartan + Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Label, Single-arm, Multicenter Phase Ib/II Study to Evaluate the Safety and Efficacy of T-Dxd in Combination With Ramucirumab as a 2nd Line in Patients With HER2 Low Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer|Gastroesophageal Junction (GEJ) Cancer
Interventions: DRUG: T-Dxd(Trastuzmab deruxtecan), Ramucirumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Preoperative High-dose-rate Endorectal Brachytherapy and FOLFOX Chemotherapy for Rectal Cancer
Status: WITHDRAWN
Conditions: Rectal Cancer
Interventions: RADIATION: High Dose Rate Endorectal Brachytherapy (HDR-ERBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Follicle-stimulating Hormone in Treatment for Infertility
Status: ACTIVE_NOT_RECRUITING
Conditions: Female Infertility
Interventions: DRUG: Recombinant Human Follicle Stimulating Hormone 900 IU (66.0 μg) / 1.5mL Solution for Injection in Prefilled Pen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Venetoclax, Carmustine, Etoposide, Cytarabine, and Melphalan Before Stem Cell Transplant in Treating Participants With Relapsed or Refractory Non-Hodgkin Lymphoma
Status: UNKNOWN
Conditions: Hematopoietic Cell Transplantation Recipient|Recurrent Diffuse Large B-Cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Non-Hodgkin Lymphoma|Refractory Diffuse Large B-Cell Lymphoma|Refractory Follicular Lymphoma|Refractory Marginal Zone Lymphoma|Refractory Non-Hodgkin Lymphoma|Refractory Transformed Indolent Non-Hodgkin Lymphoma
Interventions: DRUG: Carmustine|DRUG: Cytarabine|DRUG: Etoposide|PROCEDURE: Hematopoietic Cell Transplantation|DRUG: Melphalan|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EpiCor Clinical Study on Rapid Immune Modulating Effects
Status: COMPLETED
Conditions: Immune Surveillance
Interventions: DIETARY_SUPPLEMENT: Yeast Fermentate (EpiCor)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Burn Study- Tranexamic Acid Versus Thrombin in Split Thickness Skin Graft
Status: NOT_YET_RECRUITING
Conditions: Burns|Skin Graft Complications
Interventions: DRUG: Tranexamic acid|DRUG: Thrombin JMI|PROCEDURE: skin graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT