pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Dissemination of Cervical Cancer Screening to Primary Care Physicians in Underserved Communities
Status: TERMINATED
Conditions: Cervical Cancer
Interventions: BEHAVIORAL: Academic Detailing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Simplification From Tenofovir Plus Lamivudine or Emtricitabine Plus Ritonavir-Boosted-Protease Inhibitor to Ritonavir-Boosted-Atazanavir Plus Lamivudine in Virologically-Suppressed-HIVInfected Adults With Osteopenia
Status: UNKNOWN
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: Boosted atazanavir|DRUG: Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of rhTPO for the Treatment of Thrombocytopenia After Chemotherapy in AML Patients
Status: COMPLETED
Conditions: Thrombocytopenia
Interventions: DRUG: recombinant human thrombopoietin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate SAR441566 Efficacy and Safety in Adults With Rheumatoid Arthritis
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: SAR441566|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|DRUG: Cytarabine|DRUG: Daunorubicin Hydrochloride|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine vs Nitazoxanide in Patients With COVID-19
Status: TERMINATED
Conditions: Coronavirus Infection
Interventions: DRUG: Nitazoxanide 500 MG|DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Immunogenicity of Fluval P Monovalent Influenza Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Vaccination with Fluval P and Fluval AB influenza vaccines|BIOLOGICAL: Vaccination with Fluval P monovalent influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Danish Multicenter Study of Adalimumab in Spondyloarthritis
Status: UNKNOWN
Conditions: Spondyloarthritis
Interventions: DRUG: Adalimumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Continence Across Continents to Upend Stigma and Dependency
Status: COMPLETED
Conditions: Urinary Incontinence|Falls, Accidental|Quality of Life|Stigma
Interventions: BEHAVIORAL: Continence promotion group education workshop|BEHAVIORAL: Sham health lecture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erlotinib in Treating Patients With Persistent or Recurrent Cancer of the Cervix
Status: COMPLETED
Conditions: Cervical Squamous Cell Carcinoma|Recurrent Cervical Cancer
Interventions: DRUG: erlotinib hydrochloride|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wet-suction Versus Slow-pull for EUS-FNB of Solid Lesions
Status: COMPLETED
Conditions: Endoscopic Ultrasound|Fine-needle Aspiration
Interventions: PROCEDURE: Endoscopic ultrasound-guided fine-needle biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Ultrasound and Immunological Findings in Patients With Shoulder Injury Related to Vaccine Administration (SIRVA)
Status: COMPLETED
Conditions: Shoulder Injury Related to Vaccine Administration|Erosion, Localized
Interventions: DIAGNOSTIC_TEST: Ultrasound Shoulder and Immunological Phenotyping by FACS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Frontline Treatment With Bendamustine in Combination With Rituximab in Adults Age 65 or Older With Chronic Lymphocytic Leukemia (CLL)
Status: WITHDRAWN
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Bendamustine|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ESWT on Human Gingival Fibroblasts
Status: COMPLETED
Conditions: Periodontal Attachment Loss
Interventions: DEVICE: extracorporeal shockwave device|OTHER: Fibroblast cell lines not subjected to shockwaves from extracorporeal shockwave device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: CT-evaluation of Coronary Ostia Height After Surgical Aortic Valve Replacement.
Status: ENROLLING_BY_INVITATION
Conditions: Heart Valve Diseases|Aortic Valve Stenosis|Aortic Valve Insufficiency|Regurgitation, Aortic|Stenoses, Aortic|Aortic Regurgitation|Aortic Stenosis, Severe|Coronary; Obstruction|Valve Disease, Aortic
Interventions: RADIATION: CT scan with contrast medium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Rituximab for Treatment of Multicentric Castleman Disease in Malawi
Status: ACTIVE_NOT_RECRUITING
Conditions: Multicentric Castleman Disease
Interventions: DRUG: Rituximab|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study on the Effect of LY2216684 on the Active Metabolite of Clopidogrel
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Clopidogrel|DRUG: LY2216684
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Efficacy and Safety of Generic Escitalopram in Depression
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Generic Escitalopram|DRUG: Innovator Escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide, Thalidomide and Dexamethasone in Treating Participants With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: DRUG: Dexamethasone|DRUG: Lenalidomide|DRUG: Thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyclophosphamide and Prednisone With or Without Immunoglobulin in Treating Abnormal Muscle Movement in Children With Neuroblastoma
Status: COMPLETED
Conditions: Localized Resectable Neuroblastoma|Localized Unresectable Neuroblastoma|Regional Neuroblastoma|Stage 4 Neuroblastoma|Stage 4S Neuroblastoma
Interventions: OTHER: Clinical Observation|DRUG: Cyclophosphamide|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Magnetic Resonance Imaging|DRUG: Prednisone|BIOLOGICAL: Therapeutic Immune Globulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ixazomib+Daratumumab+Dexamethasone (IDd) in Relapsed and/or Refractory Multiple Myeloma (RRMM)
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Ixazomib|DRUG: Daratumumab|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin as Adjuvant Therapy in Obese Knee Osteoarthritis Patients
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: Placebo Tablet|DRUG: Metformin Hcl 500Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Smart Heart Trial: Structured Lifestyle Intervention for Overweight and Obese Youth With Operated Heart Defects
Status: COMPLETED
Conditions: Congenital Heart Disease|Pediatric Obesity
Interventions: BEHAVIORAL: Lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Delirium in the Elderly With Donepezil: a Double-blind, Randomized, Placebo-controlled Clinical Trial
Status: TERMINATED
Conditions: Elderly|Delirium of Unknown (Axis III) Etiology|Intensive Care (ICU) Myopathy
Interventions: DRUG: Donepezil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: LOAD VS Levofloxacine Concomitant
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Doxycycline|DRUG: Levofloxacin 500mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: In-office and At-home Tooth Bleaching Using Low Concentration Peroxides.
Status: COMPLETED
Conditions: Discolored Teeth
Interventions: DRUG: hydrogen peroxide 6%|DRUG: hydrogen peroxide 15%|DRUG: Carbamide Peroxide 10%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bendamustine/Rituximab Followed by Venetoclax and Rituximab for Treatment of Chronic Lymphocytic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Bendamustine|DRUG: Venetoclax|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on Post Evaluation After Listing of Qizhi Weitong Granules
Status: UNKNOWN
Conditions: Functional Dyspepsia|Traditional Chinese Medicine
Interventions: DRUG: Qizhi Weitong Granules|DRUG: Mosapride Citrate Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Strength and Balance Training Program for Persons With Oxaliplatin Induced Neuropathy
Status: COMPLETED
Conditions: Neuropathy|Gastrointestinal Cancer
Interventions: OTHER: 12 Week Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 2 Study to Evaluate the Efficacy and Safety of HS-20004 in Type 2 Diabetes Subjects.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: HS-20004
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of TCI Propofol on Liver Transplant (TCI) Propofol on Intra-operative Usage of Vasopressors in Liver Transplant Recipients.
Status: RECRUITING
Conditions: Liver Transplant Recipients
Interventions: DRUG: Target control infusion propofol|DRUG: Inhalational isoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CRT Implant Strategy Using the Longest Electrical Delay for Non-left Bundle Branch Block Patients
Status: COMPLETED
Conditions: Non-left Bundle Branch Block|Ischemic or Non-ischemic Cardiomyopathy
Interventions: DEVICE: QLV based implant strategy|DEVICE: Standard of care implant strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Profile of Terlipressin and Octreotide in Patients With Cirrhosis and Portal Hypertension. A Randomised, Single Blinded Clinical Trial.
Status: UNKNOWN
Conditions: Liver Cirrhosis Portal
Interventions: DRUG: Terlipressin|DRUG: Terlipressin|DRUG: Octreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Tackling Dry Socket Via Laser Therapy in Smokers
Status: RECRUITING
Conditions: Alveolar Osteitis
Interventions: DEVICE: Diode laser therapy|COMBINATION_PRODUCT: Alveogyl dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Combined Modality Protons and Hepatic Transplantation for Hilar Cholangiocarcinoma
Status: NOT_YET_RECRUITING
Conditions: Cholangiocarcinoma
Interventions: RADIATION: Proton Beam Therapy|DRUG: Concurrent oral capecitabine chemotherapy|DRUG: Cisplatin & Gemcitabine intravenous chemotherapy|PROCEDURE: Orthotropic Liver Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Osteopathic Treatment in the Axial Variations of the Lumbar Spine: RCT
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: OTHER: Osteopathic manipulative treatment|OTHER: Sham Therapy|OTHER: No Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cost-effectiveness of Small Size Interarcuair Decompression Versus Extended Decompression in Patients With Intermittent Neurogenic Claudication
Status: UNKNOWN
Conditions: Stenoses, Spinal
Interventions: PROCEDURE: small size interarcuair decompression|PROCEDURE: Laminectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Venetoclax and Decitabine in Treating Participants With Relapsed/Refractory Acute Myeloid Leukemia or Relapsed High-Risk Myelodysplastic Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Blastic Plasmacytoid Dendritic Cell Neoplasm|Chronic Myelomonocytic Leukemia|Mixed Phenotype Acute Leukemia|Myelodysplastic Syndrome|Recurrent Acute Biphenotypic Leukemia|Recurrent Acute Myeloid Leukemia|Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm|Recurrent Chronic Myelomonocytic Leukemia|Recurrent Mixed Phenotype Acute Leukemia|Refractory Acute Myeloid Leukemia|Refractory Blastic Plasmacytoid Dendritic Cell Neoplasm|Refractory Chronic Myelomonocytic Leukemia|Refractory Mixed Phenotype Acute Leukemia
Interventions: DRUG: Decitabine|OTHER: Laboratory Biomarker Analysis|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chewing, Swallowing and Orofacial Motricity in Severe Obese
Status: UNKNOWN
Conditions: Mastication Disorder|Swallowing Disorder|Orofacial Dyskinesia
Interventions: OTHER: Myofacial muscle training protocol.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Cola on the Absorption of the HCV Agent Velpatasvir in Combination With PPI Omeprazole.
Status: COMPLETED
Conditions: Hepatitis C|Swallowing Disorder
Interventions: DRUG: velpatasvir|DRUG: velpatasvir|DRUG: velpatasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Study of YYJD Decoction Combined With Gefitinib in Advanced Pulmonary Adenocarcinoma
Status: UNKNOWN
Conditions: Cancer
Interventions: DRUG: gefitinib|DRUG: Yiqi-yangyin-jiedu decoction|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of KN026 Monotherapy or Combination Therapy in Patients With Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Concurrent chemotherapy and KN026|DRUG: KN026 monotherapy|DRUG: KN026 combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Cannabidiol Attenuate the Acute Effects of ∆9-tetrahydrocannabinol Intoxication in Individuals Diagnosed With Schizophrenia? A Double-blind, Randomised, Placebo-controlled Experimental Study
Status: COMPLETED
Conditions: Schizophrenia|Cannabis Use
Interventions: DRUG: Cannabidiol|DRUG: Placebo|DRUG: Delta-9-THC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Efficacy and Safety of Neoadjuvant Treatment With Pamrevlumab in Combination With Chemotherapy (Either Gemcitabine Plus Nab-paclitaxel or FOLFIRINOX) in Participants With Locally Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer Non-resectable
Interventions: DRUG: Pamrevlumab + Gemcitabine + Nab-paclitaxel or Pamrevlumab + FOLFIRINOX|DRUG: Placebo + Gemcitabine + Nab-paclitaxel or Placebo + FOLFIRINOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging Study of [89Zr]DFO-YS5 for Detecting CD46 Positive Malignancy in Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma|Plasma Cell Myeloma
Interventions: DRUG: Zirconium Zr 89-DFO-YS5|PROCEDURE: Positron Emission Tomography / Computed Tomography (PET/CT)|PROCEDURE: Positron Emission Tomography / Magnetic Resonance Imaging (PET/MRI)|OTHER: Fludeoxyglucose F-18
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Use of Naltrexone Hydrochloride to Promote Healing in Patients With Resistant Non-infectious Corneal Ulcer
Status: COMPLETED
Conditions: Cornea Ulcer
Interventions: DRUG: Naltrexone Hydrochloride|DRUG: Carboxy methyl cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-Flutemetamol and Plaque Vulnerability
Status: UNKNOWN
Conditions: Atherosclerosis
Interventions: DRUG: 18F-Flutemetamol PET/MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: An Investigational Drug, PF-02341066 Is Being Studied Versus Standard Of Care In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: PF-02341066|DRUG: Pemetrexed|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Early Complications of Two Techniques in the Laparoscopic Gastric Bypass
Status: COMPLETED
Conditions: Obesity
Interventions: PROCEDURE: Laparoscopic Gastric Bypass|PROCEDURE: Laparoscopic Gastric Bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: RESEARCH EVALUATING VAGAL EXCITATION AND ANATOMICAL LINKS
Status: RECRUITING
Conditions: Epilepsy|Depressive Disorder
Interventions: DEVICE: Vagus nerve stimulation device: acute and chronic administration of investigational vagus nerve stimulation parameters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Safety and Efficacy of Shorttime TNI Treatment in Patients With COPD
Status: UNKNOWN
Conditions: Oxygen Inhalation Therapy
Interventions: DEVICE: Nasal oxygen insufflation with a TNI 20 oxy device|DEVICE: Standard Nasal Insufflation of oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Meal Replacement With a Carbohydrates and Protein Supplement Induce Weight Loss in Overweight and/or Obese Adults?
Status: UNKNOWN
Conditions: Weight Loss
Interventions: BEHAVIORAL: satiety|DIETARY_SUPPLEMENT: Dietary Supplement: Generation UCAN supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Clinical Study of Sorafenib and Zoledronic Acid to Treat Advanced HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Sorafenib and Zoledronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sacrococcygeal Local Anesthesia With Different Doses of Clonidine for Pilonidal Sinus Surgery
Status: UNKNOWN
Conditions: Pilonidal Sinus
Interventions: DRUG: Clonidine 75 µg/mL in sacrococcygeal block|DRUG: Clonidine 150 µg/mL in sacrococcygeal block|DRUG: Lidocaine|PROCEDURE: Pilonidal sinus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vincristine and Temozolomide in Combination With PEN-866 for Adolescents and Young Adults With Relapsed or Refractory Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Sarcoma, Ewing|Rhabdomyosarcoma
Interventions: DRUG: PEN-866|DRUG: Vincristine|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gentamicin in Preventing Post Endoscopic Retrograde Cholangiopancreatography (ERCP) Cholangitis in Non-calculus Stenting
Status: COMPLETED
Conditions: Cholangitis
Interventions: DRUG: gentamicin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy, Safety, and Concentration of SNS812 in Mild to Moderate COVID-19 Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild to Moderate COVID-19
Interventions: DRUG: MBS-COV|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Canagliflozin (TA-7284) in Patients With Diabetic Nephropathy
Status: COMPLETED
Conditions: Diabetic Nephropathy
Interventions: DRUG: Canagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acetazolamide Add-On Therapy to OSA Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: Acetazolamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The SAPPHO Study: A Single-Arm, Phase II Study of Sequential Therapy With Curative Intent in de Novo HER2+ Metastatic Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer Female|Breast Cancer|Breast Cancer Metastatic|Estrogen Receptor-positive Breast Cancer|HER2-positive Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: Nab-Paclitaxel|DRUG: Paclitaxel|DRUG: Docetaxel|DRUG: Phesgo|DRUG: T-DM1|DRUG: Pertuzumab|DRUG: Trastuzumab Deruxtecan|DRUG: Trastuzumab Subcutaneous Subcutaneous|DRUG: Tucatinib|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effects of Cool Roofs on Indoor Environments and Health in Niue
Status: NOT_YET_RECRUITING
Conditions: Resting Heart Rate|Blood Glucose Control|Depression|Heat-related Symptoms|Physician Diagnosed Heat-related Illnesses|Food Insecurity|Diet Quality|Health-related Quality of Life|Indoor Thermal Comfort|Coping Ability|Life Satisfaction|Healthcare Provider Utilization|Hospitalization|Systolic Blood Pressure|Diastolic Blood Pressure|Inner Ear Canal Temperature|Dehydration|Sleep Quality|Cognition|Productivity|Aggression|Indoor Air Temperature|Indoor Relative Humidity|Indoor Heat Index|Household Energy Expenditure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Indirect Pulp Capping With Resin Modified Glass Ionomer
Status: COMPLETED
Conditions: Caries, Dental|Pulpitis
Interventions: OTHER: Partial caries removal|OTHER: Provisional restoration - control|OTHER: Provisional restoration - experimental|OTHER: Total caries removal|OTHER: Definitive restoration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Variety and Portion Size on Meal Intake of Adults
Status: WITHDRAWN
Conditions: Eating Behavior
Interventions: OTHER: Low variety|OTHER: High Variety|OTHER: Small Portion Size|OTHER: Large Portion Size|OTHER: With Beverage|OTHER: Without Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Exenatide on Glycemic Control and Weight in Continuous Subcutaneous Insulin Infusion (CSII) Type 2 Treated Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: Exenatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Time Efficiency and Obturation Quality of Rotary Versus Manual in Primary Teeth
Status: COMPLETED
Conditions: Endodontic Disease
Interventions: PROCEDURE: NSK Endo motor Endomate|PROCEDURE: manual K-files
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Medtronic Concomitant Utilization of Radio Frequency for Atrial Fibrillation CURE-AF/Persistent
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Cardioblate Surgical Ablation System|PROCEDURE: Surgical RF Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Status: RECRUITING
Conditions: Hypertension|Left Ventricular Hypertrophy|Left Ventricular Dysfunction|Left Atrial Dilatation|Left Ventricular Diastolic Dysfunction|Kidney Diseases|Kidney Injury|Kidney Dysfunction|Sodium Urine High|Blood Pressure Disorders|Uric Acid Retention|Angiotensin Hypertension|Autonomic Dysfunction|Autonomic Imbalance|Pediatric Kidney Disease|Pediatric Obesity|Proteinuria|Albuminuria
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Switch to Doravirine/Islatravir (DOR/ISL) in Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Who Are Virologically Suppressed on Antiretroviral Therapy (ART) (MK-8591A-051)
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV-1 Infection
Interventions: DRUG: ART|DRUG: DOR/ISL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modified Sling and Conventional Suture Techniques in Free Gingival Graft Operations
Status: COMPLETED
Conditions: Gingival Recession, Localized
Interventions: PROCEDURE: gingival unit graft+modified sling suture technique|PROCEDURE: Gingival unit graft and conventional suture technique|PROCEDURE: Conventional graft and modified sling suture technique|PROCEDURE: Conventional graft and conventional suture technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Screening of Liver Fibrosis Using Blood Tests in Patients With Type 2 Diabetes Mellitus
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|NAFLD|NASH
Interventions: DIAGNOSTIC_TEST: Blood tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination Drug-Therapy for Patients With Untreated Obstructive Sleep Apnea
Status: COMPLETED
Conditions: OSA|Obstructive Sleep Apnea
Interventions: DRUG: Acetazolamide|DRUG: Eszopiclone|DRUG: Placebo|DRUG: Venlafaxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Echocardiography Sub-Study of the Umbilical Cord Milking in Non-Vigorous Infants Trial (MINVI)
Status: COMPLETED
Conditions: Birth Asphyxia
Interventions: PROCEDURE: Umbilical Cord Milking|PROCEDURE: Early Cord Clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Controlled Trial of Vertebroplasty for Acute Painful Osteoporotic Fractures
Status: COMPLETED
Conditions: Vertebral Compression Fractures|Osteoporotic Vertebral Compression Fractures|Acute Vertebral Fractures
Interventions: PROCEDURE: Vertebroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS)
Status: WITHDRAWN
Conditions: Idiopathic Refractory Scleritis
Interventions: DRUG: Infliximab|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pyronaridine in Healthy Adult Participants Infected With Blood Stage Malaria
Status: COMPLETED
Conditions: Malaria,Falciparum|Malaria|Malaria Recrudescence|Parasitemia|Protozoan Infections|Parasitic Disease
Interventions: DRUG: Pyronaridine|BIOLOGICAL: P. falciparum IBSM infection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Doxycycline for COPD in HIV-Infected Patients
Status: COMPLETED
Conditions: HIV|Chronic Obstructive Pulmonary Disease (COPD)|Emphysema
Interventions: DRUG: Doxycycline|DRUG: Placebo (sugar pill)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Kids Safe and Smokefree (KiSS)
Status: COMPLETED
Conditions: Second Hand Tobacco Smoke|Nicotine Dependence
Interventions: BEHAVIORAL: Clinic Quality Improvement + Behavioral Counseling|BEHAVIORAL: Clinic Quality Improvement + Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Training and tDCS for Children With FASD
Status: COMPLETED
Conditions: Fetal Alcohol Spectrum Disorders
Interventions: DEVICE: Active tDCS|BEHAVIORAL: Cognitive training|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized Selinexor-based Therapy for Relapsed/Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma in Relapse
Interventions: DRUG: Selinexor|DRUG: Pomalidomide|DRUG: Daratumumab|DRUG: Carfilzomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Radial Extracorporeal Shock Wave Therapy as Additional Treatment Modality for Spastic Equinus Deformity in Chronic Hemiplegic Patients
Status: RECRUITING
Conditions: Hemiplegic Patients
Interventions: DEVICE: radial extracorporeal shock wave therapy|DEVICE: sham radial extracorporeal shock wave therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Microtuning a Bonafide Treatment for GAD Patients - A Randomized Controlled Trial.
Status: COMPLETED
Conditions: Dyadic Peer-tutoring|Adherence Priming|Resource Priming
Interventions: BEHAVIORAL: Cognitive behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Transcranial Direct-Current Stimulation (tDCS) for Provoked Vestibulodynia : a Triple Blind Randomized Controlled Trial
Status: COMPLETED
Conditions: Provoked Vestibulodynia
Interventions: DEVICE: Active tDCS or Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Severe PID With Lymphoproliferation and Neutropenia
Status: COMPLETED
Conditions: Primary Immune-Deficiency (PID) Common Variable Immune Deficiency (CVID)
Interventions: GENETIC: FACS analyses|GENETIC: Target Sequencing by NGS ( Next-generation sequencing)|GENETIC: Whole Exome Sequencing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: CLARITI (TM) 1-Day Multifocal Contact Lenses Performance and Acceptance Evaluation
Status: COMPLETED
Conditions: Presbyopia Correction
Interventions: DEVICE: Test (multi-focal)|DEVICE: Control (Sphere)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous and Intraperitoneal Lignocaine for Perioperative Analgesia in Laparoscopic Colon Resections
Status: COMPLETED
Conditions: Laparoscopic Colon Resection|Perioperative Analgesia
Interventions: DRUG: IV Saline bolus and infusion|DRUG: IP Saline bolus and infusion|DRUG: IV lignocaine bolus and infusion|DRUG: IP Lignocaine bolus and infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Prolonged Decubitus on Nitric Oxide Concentration in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Airway Disease
Interventions: DEVICE: Cardioline Exp'air by Medi-soft - Sorinnes (B)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Randomized Phase 2 Study of 3 Therapeutic Modalities in PS 2/3 Patients With NSCLC Stage IIIB/IV
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Gefitinib|DRUG: gemcitabine|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Glucosanol in Reducing Body Weight in Overweight and Obese Subjects
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: DEVICE: Glucosanol|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Serplulimab Plus Bevacizumab and Chemotherapy in NSCLC Patients With Brain Metastases
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer Stage II|Bevacizumab|Immunotherapy|Brain Metastases
Interventions: DRUG: Serplulimab combined with bevacizumab and first-line chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Specific Programme for the Recovery of Autonomy Plus Multimodal Physical Exercise in Oncology Patients With Dyspnoea
Status: UNKNOWN
Conditions: Cancer|Dyspnea
Interventions: OTHER: Oncological functional reeducation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Supportive Therapies for Symptom Relief From Pediatric Upper Respiratory Infections (URIs)
Status: WITHDRAWN
Conditions: Acute Upper Respiratory Infection|Signs and Symptoms
Interventions: DEVICE: Handheld humidifier
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Tolerability, and Anti-HIV Activity of DMP 266 (Efavirenz) in Combination With Nelfinavir in HIV-Positive Children
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Nelfinavir mesylate|DRUG: Efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Ticagrelor in Elderly Patients Undergoing Percutaneous Coronary Intervention
Status: COMPLETED
Conditions: Platelet Aggregation Inhibitors|Dual Anti-Platelet Therapy|Aged|Percutaneous Coronary Intervention
Interventions: DRUG: Ticagrelor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Extra-fine Formoterol/Beclomethasone in Asthmatic Crisis
Status: UNKNOWN
Conditions: Asthma|Asthmatic Crisis
Interventions: DRUG: Extra fine Formoterol/Beclomethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: High Dose Cholecalciferol to Reduce the Incidence of Gestational Diabetes in High Risk Pregnant Women
Status: WITHDRAWN
Conditions: Gestational Diabetes
Interventions: DRUG: 4000 IU vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Niacin and Rosiglitazone in Dysmetabolic Dyslipidemia
Status: COMPLETED
Conditions: Metabolic Syndrome X|Insulin Resistance
Interventions: DRUG: fenofibrate|DRUG: niacin|DRUG: rosiglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Topical Lidocaine During Urodynamic Testing In Women
Status: COMPLETED
Conditions: Urinary Stress Incontinence|Pain
Interventions: DRUG: lidocaine 2% gel|DRUG: water soluble lubricant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Tafoxiparin to Treat Primary Slow Progress of Labor Including Prolonged Latent Phase and Labor Arrest
Status: COMPLETED
Conditions: Labor, Obstetric
Interventions: DRUG: DF 01|DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Aerobic or Resistance Exercise on the Endothelial Response in Post-acute Myocardial Infarction Patients Submitted to Angioplasty
Status: COMPLETED
Conditions: Cardiac Rehabilitation|Aerobic Exercise|Resistance Exercise
Interventions: OTHER: Resistance exercise session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
Status: RECRUITING
Conditions: Hematologic Malignancies|Waldenstroms Macroglobulinaemia|Non-Hodgkins Lymphoma|Chronic Lymphocytic Leukaemia
Interventions: DRUG: Nemtabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Pharmacodynamics, and Safety of Moss-aGalactosidase A in Patients With Fabry Disease
Status: COMPLETED
Conditions: Fabry Disease
Interventions: DRUG: Moss-aGal (recombinant human alpha-galactosidase A produced in moss)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Investigation of the WaveLight® EX500 Excimer Laser
Status: COMPLETED
Conditions: Hyperopia|Hyperopic Astigmatism
Interventions: DEVICE: WaveLight EX500 excimer laser system|PROCEDURE: LASIK
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using mHealth to Improve Adherence and Reduce Blood Pressure in Individuals With Hypertension and Bipolar Disorder
Status: RECRUITING
Conditions: Bipolar Disorder|Non-Adherence, Medication|Hypertension
Interventions: BEHAVIORAL: iTAB-CV|BEHAVIORAL: Self-Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endo-biliary Laser Excision of Biliary Stenoses
Status: WITHDRAWN
Conditions: Biliary Tract Disease|Bile Duct Obstruction
Interventions: DEVICE: Benign Biliary Stenosis, Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Durvalumab + Intraductal Radiofrequency Ablation (ID-RFA) in Extrahepatic Cholangiocarcinoma
Status: RECRUITING
Conditions: Extrahepatic Cholangiocarcinoma|Unresectable Perihilar or Ductal CCA
Interventions: DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Durvalumab|PROCEDURE: ID-RFA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MabThera/Rituxan (Rituximab) in Patients With Relapsed Centroblastic Centrocytic Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: rituximab [MabThera/Rituxan]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibudilast in the Treatment of Patients With Chronic Migraine.
Status: COMPLETED
Conditions: Migraine Headache
Interventions: DRUG: Ibudilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Duloxetine RCT on Postop TKA Outcomes
Status: RECRUITING
Conditions: Pain, Postoperative|Total Knee Arthroplasty
Interventions: DRUG: Duloxetine|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study for Crizotinib Encapsulated Microsphere Formulation (eMS)
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Crizotinib|DRUG: Crizotinib|DRUG: Crizotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Gemcitabine With/Out Capecitabine in Locally Advanced, Unresectable, or Metastatic Biliary Cancer
Status: TERMINATED
Conditions: Extrahepatic Bile Duct Cancer|Gallbladder Cancer|Liver Cancer
Interventions: DRUG: capecitabine|DRUG: gemcitabine hydrochloride|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Assess the Glucose Lowering Effect of Metformin and Sitagliptin in Adolescents With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Sitagliptin|DRUG: Metformin|DRUG: Sitagliptin + Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Therapy and Neuroactive Steroids Therapy Does Not Modulate Serum Level of Neuroactive Steroids
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Neuroproprioceptive facilitation and inhibition physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Recombinant Humanized Anti-CD47/PD-1 Bifunctional Antibody HX009 in Patients With Relapsed/Refractory Lymphoma
Status: UNKNOWN
Conditions: Relapsed/Refractory Lymphoma
Interventions: DRUG: Recombinant humanized anti-CD47/PD-1 bifunctional antibody HX009 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Videothoracoscopic (VATS) vs. Robotic Approach for Lobectomy or Anatomical Segmentectomy
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: PROCEDURE: VATS|PROCEDURE: RATS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT