pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of the Safety, Tolerance, and Pharmacokinetics of Oral Posaconazole in Immunocompromised Children (P03579)
Status: TERMINATED
Conditions: Fungal Infections
Interventions: DRUG: Posaconazole 12 mg/kg/day BID|DRUG: Posaconazole 18 mg/kg/day BID|DRUG: Posaconazole 18 mg/kg/day TID|DRUG: Posaconazole 12 mg/kg/day TID
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Pharmacodynamic Effect of the Combination of Sildenafil and Riociguat on Blood Pressure and Other Safety Parameters.
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Riociguat (Adempas, BAY63-2521)|DRUG: Placebo|DRUG: Sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Expanded Access to T-cell Depleted Haplo-Identical Stem Cells for Patients Receiving Haplo-Identical and Unrelated Cord Blood Transplants
Status: AVAILABLE
Conditions: Hematologic Malignancies|Inborn Errors of Metabolism Disorders|Immune Deficiencies
Interventions: BIOLOGICAL: CliniMACS CD34 Reagent System
Study Type: EXPANDED_ACCESS
Clinical trial: Evaluation of the Compatibility of Different Eye Lid Retractors to the Direct Selective Laser Trabeculoplasty (DSLT) Procedure
Status: COMPLETED
Conditions: OAG - Open-Angle Glaucoma
Interventions: DEVICE: Lid retractor placement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Dietary Nitrate on Age-related Vascular Function
Status: COMPLETED
Conditions: Endothelial Dysfunction
Interventions: DIETARY_SUPPLEMENT: Nitrate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Paroxetine- and Placebo-Controlled Study of 50 mg/Day and 100 mg/Day of EB-1010 Among Outpatients With Major Depressive Disorder Who Have Responded Inadequately to Prior Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: EB-1010 25mg BID|DRUG: SSRI Active|DRUG: EB-1010 50mg BID|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Electromagnetic Treatment For Bone Loss After Forearm Fracture
Status: COMPLETED
Conditions: Bone Disease, Metabolic|Osteopenia|Osteoporosis, Post-Traumatic
Interventions: DEVICE: Pulsing electromagnetic field (PEMF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Nabilone for the Treatment of Phantom Limb Pain
Status: COMPLETED
Conditions: Phantom Limb Pain|Neuropathic Pain
Interventions: DRUG: Nabilone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ethanol and Genetic Polymorphisms on Bupropion Metabolism
Status: WITHDRAWN
Conditions: Alcohol Drinking|Depression|Smoking Cessation|Attention Deficit Disorder
Interventions: OTHER: Trial Withdrawn 1|OTHER: Trial Withdrawn 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and Tolerability of Alirocumab SAR236553 (REGN727) in Patients With Hepatic Impairment and in Healthy Subjects
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: alirocumab SAR236553 (REGN727)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Imipramine Treatment for Patients With Multi-organ Bodily Distress Syndrome
Status: COMPLETED
Conditions: Somatisation Disorder|Somatoform Disorders
Interventions: DRUG: Imipramine treatment|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Potential Efficacy of Human Wharton's Jelly-derived Mesenchymal Stem Cells With Charcot-Marie-Tooth Disease Type 1E
Status: NOT_YET_RECRUITING
Conditions: Charcot-Marie-Tooth Disease, Type 1
Interventions: BIOLOGICAL: human Wharton's jelly-derived mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Platelet-rich Plasma (APRP) in the Treatment of Neurotrophic Keratopathy
Status: RECRUITING
Conditions: Neurotrophic Keratopathy
Interventions: OTHER: PFAT first|OTHER: APRP first
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Randomized International Study on the Reactivation of Burn Injuries
Status: WITHDRAWN
Conditions: Burns|Skin Graft (Allograft)(Autograft) Failure
Interventions: DEVICE: EmoLED|PROCEDURE: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Trastuzumab Emtansine in Indian Patients With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Unresectable Locally Advanced or Metastatic Breast Cancer Who Have Received Prior Treatment With Trastuzumab and a Taxane
Status: COMPLETED
Conditions: HER2 Positive Breast Cancer, Metastatic Breast Cancer, Locally Advanced Breast Cancer
Interventions: DRUG: Trastuzumab emtansine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Adjuvant Pembrolizumab vs Observation Following Curative Resection for Stage I Non-small Cell Lung Cancer (NSCLC) With Primary Tumors Between 1-4 cm
Status: RECRUITING
Conditions: NSCLC, Stage I
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Amantadine on Postoperative Cognitive Dysfunction
Status: UNKNOWN
Conditions: Postoperative Cognitive Dysfunction
Interventions: DRUG: Amantadine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A New Theory of Electrophysiological Mechanism of Atrial Fibrillation
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: PVI + SPEs ablation|PROCEDURE: PVI ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Comparison Study of NK-104-CR (Controled Release) in Patients With Primary Hyperlipidemia or Mixed Dyslipidemia
Status: WITHDRAWN
Conditions: Hyperlipidemia|Dyslipidemia
Interventions: DRUG: NK-104-CR|DRUG: Placebo|DRUG: Livalo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Beverage Rich in Fruit Extracts on Risk Factors Associated With Cardiovascular Disease
Status: UNKNOWN
Conditions: Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: High polyphenol beverage|DIETARY_SUPPLEMENT: Placebo Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Study Using Metaphyseal Cones Versus a Cemented Stem Construct in Revision TKR
Status: ACTIVE_NOT_RECRUITING
Conditions: Total Knee Arthroplasty
Interventions: PROCEDURE: short or long stemmed rTKR cemented|PROCEDURE: Cone with short stem|PROCEDURE: Cone with long stem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Lotus Valve for Transcatheter Aortic Valve Replacement
Status: TERMINATED
Conditions: Aortic Stenosis
Interventions: DEVICE: Lotus Valve System|DEVICE: CoreValve/Evolut R Transcatheter Aortic Valve Replacement System|DEVICE: LOTUS Edge Valve System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketones Supplementation and Postprandial Lipemia
Status: WITHDRAWN
Conditions: Obesity|Overweight and Obesity|Overweight|Triglycerides High
Interventions: DIETARY_SUPPLEMENT: Ketone Ester|DIETARY_SUPPLEMENT: Ketone Salt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Efficacy and Safety of MEDI7352 in Subjects With Painful Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Painful Osteoarthritis of the Knee
Interventions: BIOLOGICAL: MEDI7352|BIOLOGICAL: MEDI7352|BIOLOGICAL: MEDI7352|BIOLOGICAL: MEDI7352|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Trial of Sorafenib Plus Ixabepilone in HER2-Negative Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Sorafenib|DRUG: Ixabepilone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pentoxifylline in Improving Oxygenation in Hepatopulmonary Syndrome
Status: UNKNOWN
Conditions: Hepatopulmonary Syndrome
Interventions: DRUG: Pentoxifylline|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Surfactant Via Endotracheal Tube vs. Laryngeal Mask Airway (LMA) in Preterm Neonates With Respiratory Distress Syndrome
Status: TERMINATED
Conditions: Respiratory Distress Syndrome, Newborn
Interventions: DEVICE: Endotracheal intubation|DEVICE: Laryngeal mask airway|DRUG: remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Vaccination Reminder/Recall Systems for Adolescent Patients
Status: COMPLETED
Conditions: Human Papilloma Virus (HPV)|Tetanus-diphtheria-acellular Pertussis (Tdap)|Meningococcal Infection|Varicella
Interventions: OTHER: Reminder/recall notices for vaccines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Feasibility Study to Identify T-cell Responses to Neo-epitopes in Tumor Invaded Lymph Nodes (NeoEpitope)
Status: COMPLETED
Conditions: Breast Cancer|Cutaneous Melanoma
Interventions: PROCEDURE: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Resection in Pancreatic Cancer With Minimal Metastatic Disease or Venous Infiltration Trial at Technische Universität München
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: PROCEDURE: Resection of metastases|PROCEDURE: Resection of infiltrated veins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating PCSK9 Binding antiBody Influence oN coGnitive HeAlth in High cardiovascUlar Risk Subjects
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: BIOLOGICAL: Evolocumab|DRUG: Placebo|DRUG: Background Statin Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of the Safety and Immunogenicity of Hepatitis A Vaccine
Status: UNKNOWN
Conditions: Vaccination
Interventions: BIOLOGICAL: Hepatitis A (Live) Vaccine, Freeze-dried produced by Changchun|BIOLOGICAL: Hepatitis A (Live) Vaccine, Freeze-dried produced by Zhejiang|BIOLOGICAL: Hepatitis A (Live) Vaccine, Freeze-dried produced by the Institute of Medical Biology, CAMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Resin Polymer (NuSmile BioFlx) Compared to Stainless Steel Crowns (3M ESPE) for Restoration of Primary Molar Teeth
Status: NOT_YET_RECRUITING
Conditions: Dental Caries|Tooth Decay
Interventions: OTHER: Resin polymer (NuSmile Bioflx) crown|OTHER: Stainless steel crown
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Informative Letters on the Prescription and Receipt of Schedule II Controlled Substances
Status: COMPLETED
Conditions: Economics|Fraud|Delivery of Health Care|Health Expenditures|Centers for Medicare and Medicaid Services (U.S.)
Interventions: OTHER: Informative letter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Quadruple Therapy Versus Dual Therapy as Rescue Regimens for Helicobacter Pylori Infection
Status: COMPLETED
Conditions: Rescue Therapy for Helicobacter Pylori
Interventions: DRUG: RBLF|DRUG: RA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Expanded, Universal Donor Natural Killer Cells for Relapsed/Refractory AML
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: Universal Donor Natural Killer Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of 128-channel EEG Combined With BESA Dipole Localization and Intervention on Brain Waves for Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DEVICE: cathode tDCS|DEVICE: Sham cathode tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peri-Operative Steroid Management in Patients
Status: COMPLETED
Conditions: Pituitary Adenoma|Pituitary Diseases
Interventions: DRUG: hydrocortisone|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study of Online Psychoeducation for Family Caregivers of People With Dementia
Status: COMPLETED
Conditions: Dementia
Interventions: BEHAVIORAL: Online psychoeducation|BEHAVIORAL: Face-to-face psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Compare the Tolerability of Microencapsulated Iron Compared to a Conventional Iron Supplement in the Market
Status: COMPLETED
Conditions: Supplement
Interventions: DIETARY_SUPPLEMENT: Experimental product consumption|DIETARY_SUPPLEMENT: Comparator product consumption (Iron sulphate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Whole-Body Electrical Stimulation in Patients Undergoing Lung Transplantation
Status: NOT_YET_RECRUITING
Conditions: Lung Transplantation|Electric Stimulation
Interventions: OTHER: Whole-body electrical stimulation|OTHER: Routine physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeting Right Ventricle in Pulmonary Hypertension Gilead
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Ranolazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eye Movement Desensitization and Reprocessing (EMDR) in Complex Psychotrauma
Status: COMPLETED
Conditions: Complex Post-Traumatic Stress Disorder
Interventions: OTHER: Scale SUD|OTHER: VOC scale|OTHER: DES II scale
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of Intradiscal Injection of Autologous BM-MSC in Subjects With Chronic LBP Due to Multilevel Lumbar IDD
Status: UNKNOWN
Conditions: Intervertebral Disc Degeneration|Chronic Low-back Pain
Interventions: DRUG: Autologous BM-MSC|PROCEDURE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Window of Opportunity Pilot Study of Pembrolizumab in Obesity-driven Endometrial Cancer
Status: TERMINATED
Conditions: Endometrial Cancer|Uterine Cancer
Interventions: DRUG: Pembrolizumab|PROCEDURE: Hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Human Tissue Distribution of Orally Supplemented Natural Vitamin E Tocotrienol
Status: COMPLETED
Conditions: End Stage Cardiac Failure|Pulmonary Failure|End Stage Liver Disease|Morbid Obesity|Recalcitrant Epilepsy Requiring Surgery|Healthy Subjects
Interventions: DIETARY_SUPPLEMENT: To surgery patients, Tocopherol capsules.|DIETARY_SUPPLEMENT: Tocotrienol to healthy subjects.|DIETARY_SUPPLEMENT: To surgery patients, Tocotrienol capsules.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Singing Exercises to Improve Symptoms of Snoring and Sleep Apnea
Status: COMPLETED
Conditions: Snoring|Upper Airway Resistance Syndrome|Obstructive Sleep Apnea
Interventions: BEHAVIORAL: Singing exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: US-Guided Preemptive Brachial Plexus Blockade May Reduce Post-operative Pain: a Randomized Study
Status: COMPLETED
Conditions: Postoperative Pain|Rotator Cuff Injuries
Interventions: DRUG: Standard group|DRUG: Preemptive group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Iron Bioavailability From MyPyramid Menus
Status: COMPLETED
Conditions: Nonheme Iron Absorption
Interventions: BEHAVIORAL: My Pyramid menu days 1, 2, 3, 4, 5, 6 or 7
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Investigate Wound Healing, Aesthetics & Pt Satisfaction Post NAC Reconstruction Using a Decellularized Donor NAC Graft
Status: RECRUITING
Conditions: Post-Mastectomy Breast Deformity (Disorder)
Interventions: PROCEDURE: Regenerative post mastectomy surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Effectiveness of AMG 334 Injection in Preventing Migraines in Adults Having Failed Other Therapies
Status: COMPLETED
Conditions: Episodic Migraine
Interventions: BIOLOGICAL: AMG334 (70 mg) Pre-Filled Syringe (PFS)|BIOLOGICAL: Placebo Pre-Filled Syringe (PFS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Combined Therapy in Radiation Proctopathy
Status: COMPLETED
Conditions: Chronic Radiation Proctitis
Interventions: DRUG: Sucralfate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Lu AA39959 in Patients With Bipolar Depression
Status: TERMINATED
Conditions: Bipolar Disorder
Interventions: DRUG: Lu AA39959|DRUG: Placebo|DRUG: Quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase IB & II Study of Ribociclib With Trastuzumab Plus Letrozole in Postmenopausal HR+, HER2+ Advanced Breast Cancer Patients
Status: UNKNOWN
Conditions: HER2-positive Breast Cancer|Postmenopausal|Metastatic Breast Cancer
Interventions: DRUG: Ribociclib, Trastuzumab, Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Bioequivalence Test (Fasting & Postprandial) of Iloperidone Tablets
Status: UNKNOWN
Conditions: Bioequivalence
Interventions: DRUG: Iloperidone 1 MG|DRUG: Placebo|DIETARY_SUPPLEMENT: fasting|DIETARY_SUPPLEMENT: postprandial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: E7389 in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: eribulin mesylate|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide, Bendamustine and Rituximab as First-line Therapy for Patients Over 65 Years With Mantle Cell Lymphoma.
Status: COMPLETED
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: lenalidomide, bendamustine, rituximab|DRUG: lenalidomide, bendamustine, rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Maximal Tumor Debulking of Multi-organ Colorectal Cancer Metastases
Status: RECRUITING
Conditions: Multi-organ Metastatic Colorectal Cancer
Interventions: DRUG: XELOX regimen according to standard procedures|DRUG: FOLFOX regimen according to standard procedures|PROCEDURE: Surgery|OTHER: radiofrequency ablation (RFA)|OTHER: transarterial chemo-embolization using irinotecan drug-eluted beads ((DEBIRI-)TACE)|RADIATION: stereotactic body radiation therapy (SBRT)|DRUG: Bevacizumab|PROCEDURE: tumor biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Study of Postoperative Adjuvant Therapy for Gastric Cancer Using TS-1 or TS-1+PSK
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: Tegafur-gimeracil-oteracil potassium (TS-1)|DRUG: Krestin (PSK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Versus Open Gastrectomy for Elderly Local Advanced Gastric Cancer Patients
Status: UNKNOWN
Conditions: Advanced Gastric Cancer
Interventions: PROCEDURE: Laparoscopic gastrectomy|PROCEDURE: Open gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lidocaine, Dexmedetomidine, Esmolol and Magnesium Effect on Optic Nerve Sheath Diameter After Laryngoscopy
Status: RECRUITING
Conditions: Intracranial Hypertension|Endotracheal Intubation|Optic Nerve Sheath Diameter|General Anesthesia
Interventions: DIAGNOSTIC_TEST: optic nerve ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Corneal Anatomical Match Between Donor and Recipient During DALK Surgery on Final Visual and Refractive Outcomes in Patients With KCN
Status: UNKNOWN
Conditions: Keratoconus
Interventions: PROCEDURE: After mechanical trephination, horizontal meridian of donor's cornea sutured to horizontal meridian of recipient cornea|PROCEDURE: : After mechanical trephination, horizontal meridian of donor's cornea sutured to vertical meridian of recipient cornea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study on the Impact of Patient Navigators on the Health Education and Quality of Life in Formerly Incarcerated Patients
Status: TERMINATED
Conditions: HIV/AIDS|Diabetes Mellitus|Hypertension|Substance Use
Interventions: BEHAVIORAL: Patient Navigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Effect of Solifenacin and Mirabegron on the Digoxin Concentrations in Blood in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects|Pharmacokinetics|Drug-Drug Interaction (DDI)
Interventions: DRUG: Mirabegron|DRUG: Solifenacin|DRUG: Digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Characterize Puff Topography With Use of JUUL 5% Electronic Nicotine Delivery Systems (ENDS) in Adult Smokers
Status: COMPLETED
Conditions: Tobacco Use|Nicotine Dependence, Other Tobacco Product|Tobacco Smoking
Interventions: OTHER: JUUL 5%, Virginia Tobacco, ENDS product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Milking of the Cut-Cord During Resuscitation of Preterm Infants (The MOCC Study)
Status: UNKNOWN
Conditions: Preterm Infant
Interventions: PROCEDURE: MOCC Group|PROCEDURE: DCC Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Measure Filgotinib in the Blood of Children and Teenagers With Arthritis Taking Filgotinib (SCALESIA)
Status: RECRUITING
Conditions: Juvenile Idiopathic Arthritis
Interventions: DRUG: Filgotinib|DRUG: Filgotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: National Liver Cancer Screening Trial
Status: RECRUITING
Conditions: Carcinoma, Hepatocellular|Liver Cancer|Liver Cirrhosis|Hepatitis B
Interventions: DIAGNOSTIC_TEST: GALAD|DIAGNOSTIC_TEST: Liver Ultrasound with or without AFP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Targeted and Tailored Pharmacist Intervention to Improve Adherence to Antihypertensive Drugs Among Diabetes Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Hypertension|Medication Nonadherence
Interventions: BEHAVIORAL: Reminders, habit-based strategies and/or involvement of family member|BEHAVIORAL: Counselling to increase knowledge|BEHAVIORAL: Counselling to increase motivation|BEHAVIORAL: Explore/address other drug related problems|BEHAVIORAL: Usual care based on the Indonesian guideline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Tretinoin, Cytarabine, and Daunorubicin Hydrochloride With or Without Arsenic Trioxide Followed by Tretinoin With or Without Mercaptopurine and Methotrexate in Treating Patients With Acute Promyelocytic Leukemia
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Promyelocytic Leukemia (M3)|Childhood Acute Promyelocytic Leukemia (M3)|Untreated Adult Acute Myeloid Leukemia|Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies
Interventions: DRUG: tretinoin|DRUG: daunorubicin hydrochloride|DRUG: cytarabine|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: arsenic trioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OPG/Soluble RANKL (sRANKL) and Bone Mineral Density in Primary Hyperparathyroidism
Status: COMPLETED
Conditions: Primary Hyperparathyroidism
Interventions: DRUG: Sedron (alendronate)|PROCEDURE: Parathyroidectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Long-Term Safety and Efficacy Study of Eszopiclone in Elderly With Primary Chronic Insomnia
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: Eszopiclone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cells (MSCs) in Inflammation-Resolution Programs of Coronavirus Disease 2019 (COVID-19) Induced Acute Respiratory Distress Syndrome (ARDS)
Status: UNKNOWN
Conditions: ARDS|COVID-19
Interventions: BIOLOGICAL: MSC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label Study Using 50 Mg Liquid Etanercept Subcutaneous Injection in the Thigh to Compare an Auto-injector Device and a Manual Injection in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Men and Women
Interventions: DEVICE: etanercept (ENBREL®) via auto-injector device|OTHER: Etanercept (ENBREL®) via Manual injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Tracheotomy for Switching Between Invasive and Noninvasive Ventilation to Facilitate Weaning
Status: UNKNOWN
Conditions: Ventilator Weaning
Interventions: PROCEDURE: switching between invasive and noninvasive ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The European NAFLD Registry
Status: RECRUITING
Conditions: NAFLD|NASH|NASH - Nonalcoholic Steatohepatitis|Fibrosis, Liver|Steatosis of Liver|Hepatocellular Carcinoma|Cardiovascular Diseases|Type 2 Diabetes|Dyslipidaemia|Hypertension|Obesity|Other Associated Comorbidities
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Efficacy and Safety of Topiramate in Obese, Type 2 Diabetic Patients Inadequately Controlled on Sulfonylurea Therapy
Status: TERMINATED
Conditions: Obesity|Diabetes Mellitus, Type 2|Diabetes Mellitus, Adult-Onset
Interventions: DRUG: topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Calf Muscle Perfusion in Patients With Intermittent Claudication by 3D-reconstruction of MSOT (MSOT_IC_3D)
Status: RECRUITING
Conditions: Diagnostic Imaging|Peripheral Arterial Disease|Intermittent Claudication
Interventions: DIAGNOSTIC_TEST: MSOT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Compare of Petrolatum Gauze, Allevyn, and New Dressing, Betafoam® in the Management of Split-Thickness Skin Graft Donor Site
Status: COMPLETED
Conditions: Skin Graft
Interventions: DEVICE: Betafoam Wound Dressing|DEVICE: Petrolatum Gauze|DEVICE: Allevyn Wound Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Whey vs. Collagen on MPS
Status: COMPLETED
Conditions: Aging
Interventions: DIETARY_SUPPLEMENT: Collagen peptide|DIETARY_SUPPLEMENT: Whey protein isolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Prokinetic Effect of Selected Nutraceuticals
Status: COMPLETED
Conditions: Pulmonary Tuberculosis|Gastro-Intestinal Disorder
Interventions: OTHER: Placebo|DIETARY_SUPPLEMENT: Zingier officinale powder|DIETARY_SUPPLEMENT: Carum carvi, L powder|DIETARY_SUPPLEMENT: Mentha spicata oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cetrotide Treatment Optimization
Status: TERMINATED
Conditions: In Vitro Fertilization|Intracytoplasmic Sperm Injection
Interventions: DRUG: Cetrotide (Ovarian stimulation)|DRUG: Cetrotide (Ovarian stimulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Efficacy and Safety in Comparative Use of Investigational Product Adjuvant Treatment in Onychomycosis
Status: UNKNOWN
Conditions: Onychomycosis
Interventions: DEVICE: Nailner 2 in 1|DRUG: Ciclopirox 8%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Alfredson and Silbernagel Protocol in Competitive Athletes With Achilles Tendinopathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Achilles Tendinopathy|Tendon Injuries|Tendon Thickening|Pain, Chronic
Interventions: OTHER: Alfredson protocol|OTHER: Silbernagel protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of rhTNK-tPA in Comparison With Alteplase(Rt-PA) as Fibrinolytic Therapy of Acute STEMI
Status: COMPLETED
Conditions: Acute ST Elevation Myocardial Infarction
Interventions: DRUG: rhTNK-tPA|DRUG: alteplase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sintilimab Plus R-GemOx as Second-line Salvage Therapy in Patients With R/R DLBCL
Status: NOT_YET_RECRUITING
Conditions: Diffuse Large B Cell Lymphoma|Relapsed Diffuse Large B-Cell Lymphoma|Refractory Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Outcome Comparison of Implant-Free Bone-Patellar Tendon Autograft in Arthroscopic ACL Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injuries|Ligament; Rupture, Knee, Spontaneous|Tendon Graft; Complication, Mechanical
Interventions: PROCEDURE: Patella tendon & bone block autograft + press-fit femoral technique|PROCEDURE: Arthroscopic ACL reconstruction|DEVICE: Hamstring tendon autograft + implant fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Orelabrutinib and Obinutuzumab in Untreated Marginal Zone Lymphomas
Status: RECRUITING
Conditions: Marginal Zone Lymphoma
Interventions: DRUG: Orelabrutinib and obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nilotinib in Advanced Gastrointestinal Stromal Tumors (GIST)
Status: TERMINATED
Conditions: Gastrointestinal Stromal Tumors
Interventions: DRUG: Nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Efficacy, Pharmacokinetics And Pharmacodynamics Of Avelumab In Combination With Either Crizotinib Or PF-06463922 In Patients With NSCLC. (Javelin Lung 101)
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Avelumab|DRUG: PF-06463922|DRUG: Crizotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Kidney Disease Progression in Chronic Hepatitis B Patients on Tenofovir Alafenamide (TAF) Versus Entecavir
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Hepatitis B
Interventions: DRUG: Tenofovir alafenamide|DRUG: Entecavir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL201 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: DNL201|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Platelet Rich Fibrin for Tear Trough Rejuvenation
Status: UNKNOWN
Conditions: Tear Trough Hollowing, Under Eye Bags
Interventions: COMBINATION_PRODUCT: Hyaluronic Acid Filler and Platelet Rich Fibrin (PRF)|COMBINATION_PRODUCT: Hyaluronic Acid Filler and Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of a Program on a Nurse-led Telephone 6-month-follow-up for Uncontrolled Hypertensive Women
Status: UNKNOWN
Conditions: Arterial Hypertension|Medication Nonadherence
Interventions: OTHER: Program on a nurse-led telephone 6-month-follow-up for uncontrolled hypertensive women: a patient-tailored intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bioequivalence Study of Allopurinol 300 mg Tablets USP Under Fasting Condition
Status: COMPLETED
Conditions: Fasting State
Interventions: DRUG: Allopurinol|DRUG: Allopurinol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Approach for Embryo Transfer Medium by Adding Cytokine to Hyaluronan Enriched Embryo Transfer Medium (Embryo Glue)
Status: COMPLETED
Conditions: Infertility
Interventions: OTHER: Cytokine group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Anti-CD19:TCRζ Chimeric Antigen Receptor-T Cells in the Treatment for CD19+ B Cell Lymphoma
Status: UNKNOWN
Conditions: Lymphoma, B Cell
Interventions: BIOLOGICAL: IL-2 pre-treated CD19 cells|BIOLOGICAL: IL-7/IL-15 pre-treated CD19 cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Arteriovenous Thrombotic Events in Critically-Ill COVID-19 Patients Trial
Status: COMPLETED
Conditions: COVID-19|Venous Thromboembolism|Arterial Thrombosis
Interventions: DRUG: Unfractionated Heparin IV|DRUG: Enoxaparin 1 mg/kg|DRUG: Clopidogrel|DRUG: Unfractionated heparin SC|DRUG: Enoxaparin 40 mg SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Autologous Fibroblast Transplantation in Facial Deformities
Status: COMPLETED
Conditions: Nasolabial Folds|Glabellar Crease|Deep Wrinkles of the Forehead|Acne Scars
Interventions: BIOLOGICAL: Fibroblast|BIOLOGICAL: fibroblast and gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in Diabetes Mellitus Patients Without Prior Myocardial Infarction or Stroke Undergoing Elective Percutaneous Coronary Intervention.
Status: WITHDRAWN
Conditions: Diabetes Mellitus|Microvascular Coronary Artery Disease
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Usability of Subcutaneous Auto-injector of CT-P47 in Patients With Active Rheumatoid Arthritis
Status: NOT_YET_RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: CT-P47 AI (tocilizumab)|BIOLOGICAL: CT-P47 PFS (tocilizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of a Ross River Virus (RRV) Vaccine
Status: COMPLETED
Conditions: Ross River Virus Disease (RRVD)
Interventions: BIOLOGICAL: Formalin-treated, UV-inactivated, whole-virion, Vero cell-derived, preservative free Ross River Virus (RRV) vaccine with or without an Al(OH)3 adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluating tDCS Brain-stimulation in Depression Using MRI
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DEVICE: Left DLPFC tDCS|DEVICE: Right DLPFC tDCS|BEHAVIORAL: Cognitive task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase III Study Assessing the Efficacy, Safety and Immunogenicity of SOK583A1 Versus Eylea® in Patients With Neovascular Age-related Macular Degeneration
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: BIOLOGICAL: SOK583A1 (40 mg/mL)|BIOLOGICAL: Eylea EU (40 mg/mL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COG-UK Project Hospital-Onset COVID-19 Infections Study
Status: COMPLETED
Conditions: Covid-19|Nosocomial Infection|Coronavirus|Coronavirus Infection|SARS-CoV 2
Interventions: OTHER: Use of virus (Covid-19) genome sequence report to inform infection prevention control procedures
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Epigenetics of Post-exertional Malaise in Patients With ME/CFS
Status: COMPLETED
Conditions: Fatigue Syndrome, Chronic
Interventions: BEHAVIORAL: Exercise|OTHER: Mental Stress Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Three-dimensional Bone Regeneration Using Custom-made Meshes With and Without Collagen Membrane
Status: COMPLETED
Conditions: Surgical Procedure, Unspecified|Soft Tissue Infections|Surgical Wound Dehiscence|Bone Density|Bone Loss in Jaw
Interventions: DEVICE: Bone augmentation with cad-cam laser-sintered mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Effect of Fascial Mobilization on Gait in Patients With Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: OTHER: Fascial mobilization|OTHER: Stretching Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outcome and Safety of Intermittent Dobutamine Infusion at a Day-Care Center in Advanced Heart Failure Patients
Status: UNKNOWN
Conditions: Heart Failure
Interventions: DRUG: Dobutamine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Absolute Bioavailability (ABA) of Mobocertinib (TAK-788) and to Characterize Mass Balance, Pharmacokinetics (PK), Metabolism, and Excretion of Carbon-14 ([14C])-Mobocertinib in Male Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Mobocertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Alemtuzumab, Fludarabine, and Busulfan Followed By Donor Stem Cell Transplant in Treating Young Patients With Hematologic Disorders
Status: COMPLETED
Conditions: Congenital Amegakaryocytic Thrombocytopenia|Diamond-blackfan Anemia|Leukemia|Myelodysplastic Syndromes|Severe Congenital Neutropenia
Interventions: BIOLOGICAL: alemtuzumab|DRUG: busulfan|DRUG: cyclosporine|DRUG: fludarabine phosphate|DRUG: methotrexate|DRUG: methylprednisolone|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation|PROCEDURE: umbilical cord blood transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dexmedetomidine on Kidney Perfusion in Paediatric Patients
Status: UNKNOWN
Conditions: Congenital Heart Disease
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Budesonide for Induction of Remission in Incomplete Microscopic Colitis
Status: COMPLETED
Conditions: Incomplete Microscopic Colitis
Interventions: DRUG: Budesonide granules 9 mg|DRUG: Placebo granules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of BMS-986497 (ORM-6151) in Participants With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: BMS-986497
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Optic Nerve Sheath Diameter Changes After Laparoscopic Surgery
Status: RECRUITING
Conditions: Optic Nerve Sheath Diameter|Intracranial Pressure Increase
Interventions: OTHER: Optic nerve sheath measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC