pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effectiveness of a Butyrate Formulation and Butyrate + Polyphenol Formulation on Gut Health, Permeability and Associated Symptoms
Status: RECRUITING
Conditions: Gut Health
Interventions: DIETARY_SUPPLEMENT: Butyrate Formulation|DIETARY_SUPPLEMENT: Butyrate + Polyphenol Formulation|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dydrogesterone Versus Intravaginal Progesterone in the Luteal Phase Support
Status: COMPLETED
Conditions: Luteal Phase Defect
Interventions: DRUG: Oral dydrogesterone|DRUG: Crinone 8% gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation for Ulcerative Colitis
Status: RECRUITING
Conditions: Ulcerative Colitis|Fecal Microbiota Transplantation
Interventions: PROCEDURE: Fecal microbiota transplantation|PROCEDURE: Infusion of Saline|DRUG: 5-Aminosalicylic acid(5-ASA) and/or Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Food Study to Evaluate the Effect of KB195 on Gut Nitrogen Metabolism in Patients With Urea Cycle Disorders
Status: COMPLETED
Conditions: Urea Cycle Disorders
Interventions: OTHER: KB195 (a novel mixture of oligosaccharides)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial of Dalotuzumab in Combination With Irinotecan Versus Cetuximab and Irinotecan for Participants With Metastatic Rectal Cancers (mRC) (MK-0646-025)
Status: TERMINATED
Conditions: Rectal Neoplasms
Interventions: DRUG: Dalotuzumab|DRUG: Irinotecan|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Prophylactic Itraconazole in High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation
Status: COMPLETED
Conditions: Neuroblastoma|Brain Tumor|Retinoblastoma|Wilms Tumor|Mycoses
Interventions: DRUG: itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Diurnal and Nocturnal Effect of Simbrinza and Timolol on Intraocular Pressure and Ocular Perfusion Pressure
Status: COMPLETED
Conditions: Open Angle Glaucoma|Ocular Hypertension|Pigment Dispersion Syndrome|Pseudoexfoliation Glaucoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Helping Patients and Providers Make Better Decisions About Colorectal Cancer Screening
Status: COMPLETED
Conditions: Cancer Screening Tests
Interventions: BEHAVIORAL: Decision aid without personalized message|BEHAVIORAL: Decision aid with personalized message|BEHAVIORAL: Provider notification without personalized message|BEHAVIORAL: Provider notification with personalized message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Goal-Directed Therapist-Guided Play-Based Intervention in Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: Goal-Directed Therapist-Guided Play-Based Intervention (GD-TG-PBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-dural Puncture Headache - Needles and Biomarkers in CSF
Status: COMPLETED
Conditions: Post-dural Puncture Headache
Interventions: DEVICE: Traumatic needle|DEVICE: Atraumatic needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Analysis of Disturbances in Neurofluid Dynamics in Type I Chiari Malformations
Status: RECRUITING
Conditions: Type I Chiari Malformation|Cerebral Hemodynamic|Craniospinal Hydrodynamic|Phase Contrast MRI|Cerebrospinal Fluid
Interventions: OTHER: phase contrast sequences
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: pBFS-guided cTBS Over the Inferior Frontal Gyrus for Aphasia After Ischemic Stroke
Status: RECRUITING
Conditions: Stroke, Ischemic|Aphasia
Interventions: DEVICE: active continuous Theta Burst Stimulation|DEVICE: sham continuous Theta Burst Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Modifying Anti-platelet Treatment to Ticagrelor in Patients With Diabetes and Low Response to Clopidogrel
Status: UNKNOWN
Conditions: Diabetes Mellitus|Coronary Disease
Interventions: DRUG: Ticagrelor|DRUG: Continued clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Ultra-processed Foods on Cardiometabolic Risk Factors
Status: NOT_YET_RECRUITING
Conditions: Cardiometabolic Risk
Interventions: OTHER: Diet N-P-|OTHER: Diet N+P-|OTHER: Diet N-P+|OTHER: Diet N+P+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pain Control in Hip Arthroscopy: Comparing Lumbar Plexus Versus Peri-capsular Injection
Status: COMPLETED
Conditions: Nerve Block|Hip Arthroscopy
Interventions: PROCEDURE: Lumbar Plexus BLock|PROCEDURE: Pericapsular injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prevention of Breast Cancer Recurrence Through Weight Control, Diet, and Physical Activity Intervention
Status: UNKNOWN
Conditions: Breast Neoplasms|Recurrence
Interventions: BEHAVIORAL: Diet|BEHAVIORAL: Physical activity|BEHAVIORAL: Minimal diet intervention|BEHAVIORAL: Minimal physical activity intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: High-flow Nasal Oxygenation and Non-invasive Ventilation Strategies for the Treatment of Covid-19 Pneumonia
Status: COMPLETED
Conditions: COVID-19 Pneumonia|COVID-19 Acute Respiratory Distress Syndrome
Interventions: OTHER: HFNO and NIV
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating Pharmacokinetic Interactions With Vaginal Ring Contraceptives and ART
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DEVICE: Nuvaring|DRUG: EFV|DRUG: ATV/r|DRUG: TDF|DRUG: NRTIs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial for Localised High-risk Rhabdomyosarcoma and Rhabdomyosarcoma-like Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: trofosfamide, idarubicin, etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dual-echo and Inversion Recovery Magnetic Resonance Imaging Pulse Sequences in Diagnosis of Temporomandibular Disorders. Diagnostic Accuracy Study
Status: UNKNOWN
Conditions: Temporomandibular Joint Disorders
Interventions: DIAGNOSTIC_TEST: Dual echo MRI sequence
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: BrUOG 291: Five Fraction Partial Breast Irradiation Using Non-invasive Image-guided Breast Brachytherapy (NIBB)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DEVICE: Accuboost APBI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resuscitation of Late-preterm Infants by Using Room Air or 100% Oxygen
Status: COMPLETED
Conditions: Asphyxia
Interventions: OTHER: Resuscitation|OTHER: 100% oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypertonic Saline Nasal Irrigation and Gargling in Suspected or Confirmed COVID-19 (ELVIS COVID-19)
Status: UNKNOWN
Conditions: Upper Respiratory Tract Infections|Virus|COVID|Virus Shedding|Virus Diseases
Interventions: OTHER: NaCl Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacodynamics and Pharmacokinetics of GSK2136525 Repeat Dose in Rheumatoid Arthritis
Status: TERMINATED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Otelixizumab|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Ketotifen in Primary PCI Patients With STEMI
Status: NOT_YET_RECRUITING
Conditions: ST-segment Elevation Myocardial Infarction (STEMI)
Interventions: DRUG: Ketotifen Fumarate|DRUG: standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Decidual Sparing in cs Niche Formation
Status: NOT_YET_RECRUITING
Conditions: Cesarean Section Complications|Cesarean Section Niche
Interventions: PROCEDURE: Decidual sparing|PROCEDURE: Non decidual sparing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: The Role of Intra-articular Injection of PRP Versus Corticosteriods in Treatment of Lumbar Facet Disease
Status: COMPLETED
Conditions: Lumbar Facet Joint Syndrome
Interventions: DRUG: Lumbar Facet Joints intra-articular injection with Platelet Rich Plasma|DRUG: Lumbar Facet Joints intra-articular injection with a mixture of 0.5% lidocaine and 5mg/ml of betamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Variable Visual Stimulus as a Novel Approach for Gait Rehabilitation
Status: TERMINATED
Conditions: Gait Disorders, Neurologic
Interventions: BEHAVIORAL: Fractal visual cueing|BEHAVIORAL: Periodic visual cueing|BEHAVIORAL: Random visual cueing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Adaptation of Community Reinforcement Approach for the Treatment of Drug Addiction
Status: COMPLETED
Conditions: Substance Use Disorders|Comorbidities and Coexisting Conditions
Interventions: BEHAVIORAL: Indigenously Adapted CRA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness and the Safety of Acupuncture for Symptomatic Care of Hemodialysis Patients: A Case-series
Status: COMPLETED
Conditions: Hemodialysis|End Stage Renal Disease
Interventions: PROCEDURE: Individualized manual acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, Tolerability and Pharmacokinetics of Concomitant Administration of Tramadol With Duloxetine or Pregabalin
Status: WITHDRAWN
Conditions: Diabetic Polyneuropathy|Postherpetic Neuralgia
Interventions: DRUG: Tramadol|DRUG: Duloxetine|DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sivextro in Acute Bacterial Skin and Skin Structure Infection (ABSSSI) in Hospitalized Patients. A Global Observational Study
Status: TERMINATED
Conditions: Skin Disease, Infectious
Interventions: DRUG: Tedizolid (Sivextro, BAY1192631)|DRUG: Linezolid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Telehealth-Based Intervention to Detect and Manage Glaucoma Among High-Risk Populations
Status: NOT_YET_RECRUITING
Conditions: Adherence to In-Office Glaucoma Evaluation Appointment
Interventions: BEHAVIORAL: Telehealth-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Effect Of Music Integrated Phonological Awareness Program On Preschool Cochlear Implant Users
Status: COMPLETED
Conditions: Telerehabilitation
Interventions: OTHER: Music-Integrated Phonological Awareness training program|DIAGNOSTIC_TEST: Spectral-Temporally Modulated Ripple Test (SMRT)|DIAGNOSTIC_TEST: The Phonological Awareness Scale of Early Childhood Period (PASECP)|DIAGNOSTIC_TEST: Mismatch Negativity Test|DIAGNOSTIC_TEST: Early Language Development (TELD-3)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety, Immunogenicity and Efficacy of the Blood-stage Plasmodium Vivax Malaria Vaccine Candidate PvDBPII in Matrix M1
Status: UNKNOWN
Conditions: Malaria, Vivax
Interventions: BIOLOGICAL: PvDBPII/Matrix-M1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Pilot Study Comparing the Efficacy of Traditional Buddhist Mindfulness Training Versus Secular Mindfulness-based Cognitive Therapy for Patients Having Residual Depressive Symptoms
Status: RECRUITING
Conditions: Depression Moderate|Depression Mild
Interventions: BEHAVIORAL: Traditional Buddhist mindfulness|BEHAVIORAL: secular mindfulness based cognitive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Technology-based Physical Activity Interventions for Women After Bariatric Surgery
Status: UNKNOWN
Conditions: Bariatric Surgery Candidate
Interventions: BEHAVIORAL: Technology-based physical activity interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Early Intervention to Promote Cardiovascular Health of Mothers and Children (ENRICH) During Pregnancy
Status: RECRUITING
Conditions: Cardiovascular Diseases|Pregnancy Related|Sedentary Behavior
Interventions: BEHAVIORAL: Maternal CVH Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Antiarrhythmics Versus Implantable Defibrillators (AVID)
Status: COMPLETED
Conditions: Arrhythmia|Cardiovascular Diseases|Death, Sudden, Cardiac|Heart Diseases|Tachycardia, Ventricular|Ventricular Fibrillation
Interventions: DEVICE: defibrillators, implantable|DRUG: amiodarone amiodarone|DRUG: sotalol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Palbociclib and Letrozole or Fulvestrant in Treating Patients With Estrogen Receptor Positive, HER2 Negative Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Estrogen Receptor-positive Breast Cancer|HER2/Neu Negative|Stage IV Breast Cancer AJCC v6 and v7
Interventions: DRUG: Palbociclib|DRUG: Letrozole|DRUG: Fulvestrant|OTHER: Questionnaire Administration|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Molluscum Contagiosum Efficacy and Safety Study
Status: COMPLETED
Conditions: Molluscum Contagiosum
Interventions: DRUG: SB206 10.3% berdazimer|DRUG: vehicle gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PROMES: A Clinical Study in Which Researchers Want to Learn More About the Safety Profile of MESIGYNA (Norethisterone Enantate 50 mg and Estradiol Valerate 5 mg) Used as a Medication to Prevent Pregnancy for Adult Women in Reproductive Age in the Peruvian Population at the Outpatient Clinic.
Status: COMPLETED
Conditions: Contraceptive
Interventions: DRUG: Norethisterone enantate/estradiol valerate (Mesigyna, BAY98-7040)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Peer MI in FQHCs for Substance-using Emerging Adults
Status: UNKNOWN
Conditions: Substance Use Disorders
Interventions: BEHAVIORAL: Peer-enhanced Motivational Interviewing|BEHAVIORAL: Motivational Interviewing|OTHER: Waitlist Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Response After Pneumococcal Vaccination in Patient With Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: CLL|Vaccine Response
Interventions: BIOLOGICAL: PCV13|BIOLOGICAL: PPSV23
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy in Treating Adults With Acute Lymphocytic Leukemia
Status: UNKNOWN
Conditions: Leukemia
Interventions: DRUG: asparaginase|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: leucovorin calcium|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: mitoxantrone hydrochloride|DRUG: prednisolone|DRUG: teniposide|DRUG: thioguanine|DRUG: vincristine sulfate|DRUG: vindesine|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy of Memantine in Prevention of Oxaliplatin-induced Peripheral Neurotoxicity
Status: NOT_YET_RECRUITING
Conditions: Cancer
Interventions: DRUG: Memantine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Adductor Canal Block for Medial Compartment Knee Arthroplasty
Status: COMPLETED
Conditions: Postoperative Analgesia|Medial Unicompartmental Knee Arthroplasty
Interventions: DRUG: Adductor canal block|DRUG: Lumbar plexus block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: INBRX-106 in Combination With Pembrolizumab in First-line PD-L1 CPS≥20 HNSCC
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma (HNSCC)
Interventions: DRUG: INBRX-106|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pulsed Electromagnetic Fields (PEMF) and Post-Axillary Surgery Morbidity
Status: TERMINATED
Conditions: Shoulder Symptoms After Lymph Node Dissection
Interventions: DEVICE: PEMF Device|DEVICE: Sham PEMF Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of Multiple Doses of FG-4592 on the Exposure, Safety and Tolerability and Effect of Warfarin in Healthy Subjects
Status: COMPLETED
Conditions: Pharmacokinetics of FG-4592|Healthy Subjects
Interventions: DRUG: Warfarin|DRUG: FG-4592
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial Comparing Cetuximab With Pemetrexed/Cetuximab Therapy for Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Cetuximab|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Cetuximab Plus Raltitrexed for Maintenance Treatment in Advanced Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: Raltitrexed|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Clinical Study of Retinal Microvascular Alteration After ICL Implantation
Status: COMPLETED
Conditions: Adolescent|Adult|Human|Male|Female|Follow-up Studies|Prospective Studies|Lens Implantation, Intraocular|Myopia|Phakic Intraocular Lenses|Retinal Vessels|Postoperative Period|Preoperative Period|Tomography, Optical Coherence
Interventions: DEVICE: Optical Coherence Tomography Angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Investigating the Utilization, Effectiveness and Quality of Life in Clinical Practice in Germany for Participants With Relapsing-remitting Multiple Sclerosis Treated With Ozanimod (Zeposia®)
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis, Relapsing-Remitting
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hydroxychloroquine and Temsirolimus in Treating Patients With Metastatic Solid Tumors That Have Not Responded to Treatment
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: hydroxychloroquine|DRUG: temsirolimus|OTHER: electron microscopy|OTHER: high performance liquid chromatography|OTHER: immunologic technique|OTHER: laboratory biomarker analysis|OTHER: mass spectrometry|OTHER: pharmacological study|PROCEDURE: autophagy inhibition therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study Investigating the Safety and Efficacy of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
Status: TERMINATED
Conditions: Geographic Atrophy
Interventions: DRUG: Lampalizumab|OTHER: Sham Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nab-paclitaxel Dose Schedual for HER-2 Negative Advanced Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: nab-paclitaxel regimen1|DRUG: nab-paclitaxel regimen2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance Study of Microbio InfectID-BSI for Detection of Bacteria and Yeast With Patient Blood Samples
Status: NOT_YET_RECRUITING
Conditions: Bloodstream Infection|Sepsis|Septic Shock
Interventions: DIAGNOSTIC_TEST: InfectID-BSI (Bloodstream Infection) qPCR Assay
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate the Effect of ALS-008176 on Cardiac Repolarization Interval in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ALS-008176|DRUG: Placebo|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Efficacy, Safety and PK of Roxadustat (FG-4592) for Treatment of Anemia in Pediatric Patients With CKD
Status: WITHDRAWN
Conditions: Anemia Associated With Chronic Kidney Disease
Interventions: DRUG: Roxadustat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Subcutaneous MK-3222, Followed by an Optional Long-Term Safety Extension Study, in Participants With Moderate-to-Severe Chronic Plaque Psoriasis (MK-3222-010)
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Tildrakizumab 200 mg|DRUG: Tildrakizumab 100 mg|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Multi-ingredient on Visceral Adiposity & Non-alcoholic Fatty Liver Disease in Postmenopausal Women With Abdominal Obesity
Status: NOT_YET_RECRUITING
Conditions: Visceral Obesity|Non-alcoholic Fatty Liver|Postmenopausal
Interventions: DIETARY_SUPPLEMENT: Multi-ingredient of L-histidine, L-serine, L-carnosine and N-Acetylcysteine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VIC-1911 Combined With Osimertinib for EGFR -Mutant Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Advanced Non-small Cell Lung Cancer
Interventions: DRUG: VIC-1911|DRUG: Osimertinib Mesylate Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotic Visbiome for Inflammation and Translocation in HIV II
Status: UNKNOWN
Conditions: HIV-1 Infection
Interventions: DRUG: Visbiome|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Metformin Under Fed Conditions After Administration of Linagliptin / Metformin Fixed Dose Combination Tablet and Single Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Linagliptin/metformin|DRUG: Metformin|DRUG: Linagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ipatasertib (GDC-0068) in Combination With Fluoropyrimidine Plus Oxaliplatin in Participants With Advanced or Metastatic Gastric or Gastroesophageal Junction Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: 5-Fluorouracil|DRUG: Ipatasertib|DRUG: Leucovorin|DRUG: Oxaliplatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cryoablation of Intercostal Nerves for Pain Management in Early Postoperative Period in Patients With Minimally Invasive Mitral Valve Surgery
Status: RECRUITING
Conditions: Pain, Postoperative|Opioid Analgesic Consumption
Interventions: PROCEDURE: cryoablation of intercostal nerves
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FLEX - Long-term Extension of FIT (Fracture Intervention Trial)(0217-051)
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal
Interventions: DRUG: MK0217, alendronate sodium / Duration of Treatment : 5 Years|DRUG: Comparator : placebo (unspecified) /Duration of Treatment : 5 Years
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Balance Chiropractic Therapy for Cervical Spondylotic Radiculopathy
Status: UNKNOWN
Conditions: Cervical Radiculopathy
Interventions: DEVICE: Balance Chiropractic Therapy|DEVICE: Traction Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Potential for Clinical Dependence and Withdrawal Symptoms Associated With Valbenazine
Status: COMPLETED
Conditions: Tardive Dyskinesia (TD)
Interventions: DRUG: Valbenazine|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Immediate Implant Placement and Provisionalization in the Esthetic Zone
Status: TERMINATED
Conditions: Jaw, Edentulous, Partially
Interventions: DEVICE: immediate implant placement without provisionalization|DEVICE: immediate implant placement with immediate provisionalization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Convalescent Plasma in Treating COVID-19 Hospitalized Patients
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: anti-SARS-CoV-2 convalescent plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Analysis Between Ringer's Lactate vs Plasma Lyte-A as Cardiopulmonary Bypass Prime
Status: UNKNOWN
Conditions: Cardiopulmonary Bypass
Interventions: DRUG: Plasmalyte A|DRUG: Ringer Lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Trial of Elacestrant vs. Standard of Care for the Treatment of Patients With ER+/HER2- Advanced Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Elacestrant|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections.
Status: COMPLETED
Conditions: Sick Sinus Syndrome|Complete Heart Block|Syncope|Chronic Systolic Heart Failure
Interventions: DRUG: polymixin/bacitracin|DRUG: cephalexin, or levofloxacin, or clindamycin|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Home Grip Assistance Glove on the Use of the Upper Limb and Compliance Factors in Brain-injured Adults
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: DEVICE: Putting on the gripping glove|OTHER: ULPA questionnaire|OTHER: Motor Activity Log (MAL) Questionnaire|OTHER: Fugl-Meyer Assessment Upper Extremity (FMA-UE) questionnaire|OTHER: Score Action Arm Research Test|OTHER: EuroQol five-level (EQ-5D-5L) questionnaire|OTHER: Quebec User Evaluation of Satisfaction with Assistive Technology|OTHER: Psychosocial Impact of Assistive Devices Scale (PIADS)|OTHER: Goal Attainment Scale (GAS)|OTHER: installation and collection of accelerometers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Predictors of Proton Pump Inhibitor (PPI) Response in Eosinophilic Esophagitis
Status: WITHDRAWN
Conditions: Gastroesophageal Reflux Disease|Eosinophilic Esophagitis|Dysphagia
Interventions: DRUG: dexlansoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Pediatric Pharmacokinetics/Pharmacodynamics (PK/PD) Study
Status: COMPLETED
Conditions: Deep Vein Thrombosis|Venous Thromboembolism
Interventions: DRUG: Edoxaban low dose|DRUG: Edoxaban high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Recombinant Modified Process Hepatitis B Vaccine in Older Adults (V232-059)(COMPLETED)
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Comparator: RECOMBIVAX HB™ Hepatitis B Vaccine (Recombinant)|BIOLOGICAL: Comparator: Modified Process Hepatitis B Vaccine (Experimental)|BIOLOGICAL: Comparator: ENGERIX-B™ (currently licensed product)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Moxifloxacin Compared With Ciprofloxacin/Amoxicillin in Treating Fever and Neutropenia in Patients With Cancer
Status: TERMINATED
Conditions: Chronic Myeloproliferative Disorders|Fever, Sweats, and Hot Flashes|Infection|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Neutropenia|Precancerous Condition|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: amoxicillin-clavulanate potassium|DRUG: ciprofloxacin|DRUG: moxifloxacin hydrochloride|PROCEDURE: management of therapy complications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Soft Tissue Mobilization With and Without Neural Mobilization in Cervical Radiculopathy
Status: UNKNOWN
Conditions: Cervical Radiculopathy
Interventions: OTHER: Soft Tissue Mobilization with Neural Mobilization|OTHER: Soft Tissue Mobilization without Neural Mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability of Maximal Use Ruxolitinib Cream
Status: RECRUITING
Conditions: Prurigo Nodularis
Interventions: DRUG: Ruxolitinib Cream 1.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Parental Absence on Child's Dental Anxiety and Behaviors During Dental Treatment
Status: COMPLETED
Conditions: Dental Anxiety|Children, Only|Dental Caries
Interventions: BEHAVIORAL: Parental absence|BEHAVIORAL: Parental visual support|BEHAVIORAL: Parental presence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pancreatic Cancer Dietary Assessment Study
Status: COMPLETED
Conditions: Pancreatic Neoplasm|Pancreas Adenocarcinoma|Well-Differentiated Neuroendocrine Carcinoma|Malignant Neoplasm of Pancreas
Interventions: DIAGNOSTIC_TEST: Pancreo-KIT breath test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multi-antigen Specific CD8+ T Cells With Decitabine and Lymphodepleting Chemotherapy for the Treatment of Patients With Relapsed or Refractory AML or MDS Following an Allogeneic Hematopoietic Cell Transplantation From a Matched Donor
Status: NOT_YET_RECRUITING
Conditions: Recurrent Acute Myeloid Leukemia|Recurrent Myelodysplastic Syndrome|Refractory Acute Myeloid Leukemia|Refractory Myelodysplastic Syndrome
Interventions: BIOLOGICAL: Allogeneic CD8+ Leukemia-associated Antigens Specific T Cells NEXI-001|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Computed Tomography|DRUG: Cyclophosphamide|DRUG: Decitabine|PROCEDURE: Echocardiography|DRUG: Fludarabine|PROCEDURE: Leukapheresis|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cetuximab and Radiation Therapy in Laryngeal Cancer Patients Who Have Responded to One Cycle of Chemotherapy (SPORE)
Status: TERMINATED
Conditions: Cancer of Larynx
Interventions: DRUG: Cisplatin|DRUG: Cetuximab|DRUG: 5-Fluorouracil|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of AZD1222 for the Prevention of COVID-19 in Japan
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: AZD1222|DRUG: 0.9% (w/v) saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Anterior Perineal Plane for Ultra Low Anterior Resection of the Rectum
Status: COMPLETED
Conditions: Rectal Neoplasms|Colitis, Ischemic|Colitis, Ulcerative
Interventions: PROCEDURE: Standard abdominal approach for rectal excision|PROCEDURE: APPEAR Procedure|PROCEDURE: Proctectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of Less Invasive Stabilization System (LISS) Plating Techniques in Distal Femoral Fractures
Status: COMPLETED
Conditions: Femoral Fractures
Interventions: DEVICE: Plates to treat fractures of the distal femur|DEVICE: LISS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CPAP Therapy in Patients With Idiopathic Pulmonary Fibrosis and Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Idiopathic Pulmonary Fibrosis
Interventions: PROCEDURE: Continuous Positive Airway Pressure (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicentre, Randomised, Open-Label Study To Compare The Efficacy And Safety Of Azithromycin For 5 Days With Those Of Amoxicillin-Clavulanic Acid In Patients With Chronic Bronchitis
Status: COMPLETED
Conditions: Bronchitis, Chronic
Interventions: DRUG: Amoxicillin/clavulinic acid|DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SADBE for Congenital Melanocytic Nevi
Status: NOT_YET_RECRUITING
Conditions: Congenital Melanocytic Nevus
Interventions: DRUG: Squaric Acid Dibutyl Ester|DRUG: Ethanol Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating Best Practices for Children With Cerebral Palsy: A Pilot Study of Two Approaches
Status: UNKNOWN
Conditions: Cerebral Palsy
Interventions: PROCEDURE: Cognitive Orientation to Occupational Performance|PROCEDURE: Contemporary Treatment Approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycemic Targets for Pregnant Women With GDM and T2DM
Status: RECRUITING
Conditions: Diabetes Mellitus in Pregnancy|Diabetes, Gestational|Diabetes Mellitus, Type 2
Interventions: OTHER: Glycemic Targets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy (RT) and Temozolomide (TMZ) in Treating Patients With Newly Diagnosed Glioblastoma or Gliosarcoma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: Concurrent temozolomide|RADIATION: Concurrent radiation therapy|DRUG: 100mg/m2 adjuvant temozolomide days 1 to 5 of 28 day cycle|DRUG: 75mg/m2 adjuvant temozolomide days 1-21 of 28 day cycle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mepolizumab for COPD Hospital Eosinophilic Admissions Pragmatic Trial
Status: COMPLETED
Conditions: COPD|Eosinophilia
Interventions: DRUG: Mepolizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Galantamine in Patients With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Dementia|Alzheimer Disease
Interventions: DRUG: Galantamine hydrobromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: EFficacy of Prophylactic Clip Application in Decrease of Immediate Postpolypectomy Bleeding and Delayed Postpolypectomy Bleeding After Colonoscopic Removal for a Large Pedunculated Polyps
Status: COMPLETED
Conditions: Polyp of Large Intestine
Interventions: PROCEDURE: prophylactic clip application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial to Assess Subjects With Dry Eye Disease.
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Reproxalap Ophthalmic Solution (0.25%)|DRUG: Vehicle Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Tenofovir and Tenofovir-diphosphate, Emtricitabine and Emtricitabine-triphosphate, and Rilpivirine Once Daily Over 14 Days Following Drug Intake Cessation in Healthy Volunteers
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Eviplera®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of LBL-019 Monotherapy or Combined With Anti-PD-1 Antibody in the Treatment of Advanced Malignant Tumors
Status: RECRUITING
Conditions: Advanced Malignant Tumors
Interventions: DRUG: LBL-019 Injection|DRUG: anti-PD-1 antibody injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Arterial Pressure Based Cardiac Output for Goal-Directed Perioperative Therapy
Status: COMPLETED
Conditions: Esophageal Diseases|Gastrointestinal Diseases|Disorder of the Genitourinary System|Gynecologic Diseases|Kidney Diseases|Liver Diseases|Pancreatic Diseases|Prostate Cancer|Spinal Disease
Interventions: DEVICE: Vigileo Monitor|DEVICE: FloTrac Sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Post-Market Clinical Study of the PanOptix Intraocular Lens (IOL) in a Chinese Population
Status: COMPLETED
Conditions: Aphakia|Presbyopia
Interventions: DEVICE: AcrySof IQ PanOptix Presbyopia Correcting IOL|PROCEDURE: Cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 1% Metformin Gel in the Treatment of Class II Furcation Defects
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: DRUG: SRP and placebo|DRUG: SRP and 1% metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preemptive Analgesia With OxyContin Versus Placebo Before Surgery for Long Bone Fractures
Status: COMPLETED
Conditions: Fractures
Interventions: DRUG: Oxycodone hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Isotretinoin in Papular-Pustular Rosacea
Status: COMPLETED
Conditions: Papular-pustular Rosacea
Interventions: DRUG: isotretinoin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Relief in Patients With Chronic Low Back Pain Using HeatTens vs. Standard Care.
Status: COMPLETED
Conditions: Chronic Low Back Pain|Movement Evoked Pain
Interventions: DEVICE: HeatTens (HV-F311-E)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Education in Hand and Wrist Surgery
Status: TERMINATED
Conditions: Distal Radius Fracture
Interventions: BEHAVIORAL: Standardized Preoperative Education|BEHAVIORAL: Standard of care|BEHAVIORAL: Preoperative and postoperative questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Urine and Ultrasound Screening for Kidney Disease in Children
Status: RECRUITING
Conditions: Kidney Diseases|Diagnostic Techniques|Ultrasound|Urinalysis|Child, Only
Interventions: OTHER: Urine and Ultrasound Screening
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Phase II Study to Analyze Sarilumab in Non-Infectious Uveitis
Status: COMPLETED
Conditions: Uveitis
Interventions: DRUG: Sarilumab|DRUG: Prednisone|DRUG: Methotrexate|DRUG: Folic/folinic acid|OTHER: Placebo (for Sarilumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Magnesium Sulfate and Neuroendocrine Hormone
Status: UNKNOWN
Conditions: Arthropathy of Knee|Magnesium Sulfate|Cortisol|Dehydroepiandrosterone
Interventions: DRUG: Magnesium sulfate|DRUG: Isotonic Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Carbon Dioxide and Saline Flush to Saline Flush in TEVAR and TAVI Procedures to Reduce Cerebral Ischemia
Status: UNKNOWN
Conditions: Thoracic Aortic Aneurysm|Aortic Stenosis Symptomatic|Stroke, Complication
Interventions: PROCEDURE: Carbon Dioxide and Saline Flush|PROCEDURE: Standard Saline Flush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindful Movement in Women Receiving Adjuvant or Neoadjuvant Therapy for Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Cancer of Breast
Interventions: OTHER: Yoga|PROCEDURE: Blood draw|BEHAVIORAL: FACT-G questionnaire|PROCEDURE: Weight measurement|BEHAVIORAL: Recent Physical Activity Questionnaire|BEHAVIORAL: NHANES Food Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Restoration of Microbiota in Neonates
Status: RECRUITING
Conditions: Atopic Dermatitis|Atopic Asthma|Immunologic Activity Alteration
Interventions: OTHER: Maternal microbiota
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT