pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: the Effects of Perioperative Goal Directed and Conventional Fluid Management on the IVC Collapsibility Index
Status: COMPLETED
Conditions: Femoral Neck Fractures
Interventions: DRUG: mostcare hemodynamic monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Inhaled Nitric Oxide (NO) in Cystic Fibrosis (CF) Patients
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DRUG: Nitric Oxide 160 ppm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cultural Adaptation and Implementation of DBT for Adolescents With Emotional Disorders
Status: ACTIVE_NOT_RECRUITING
Conditions: Emotional Disorders
Interventions: BEHAVIORAL: Culturally adapted DBT-A-ST group|BEHAVIORAL: Activities-based support group (ASG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Safety and Effectiveness of Golimumab in Participants With Active Rheumatoid Arthritis Despite Methotrexate Therapy
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Golimumab|DRUG: Methotrexate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Study of Pomalidomide, Marizomib, and Low-Dose Dexamethasone in Relapsed and Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma in Relapse|Refractory Multiple Myeloma|Multiple Myeloma
Interventions: DRUG: pomalidomide|DRUG: marizomib|DRUG: low-dose dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psycho-Educational Program in Increasing Knowledge and Satisfaction and Decreasing Distress in Younger Patients With Cancer Receiving Treatment
Status: COMPLETED
Conditions: Malignant Neoplasm|Psychosocial Effects of Cancer and Its Treatment
Interventions: PROCEDURE: psychosocial assessment and care|OTHER: educational intervention|OTHER: communication skills training|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of LBSA0103 Versus Hyruan Plus Injection in Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: Placebo|DRUG: Hyruan Plus|DRUG: LBSA0103
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Methadone-Maintained Smokers Switching to E-Cigarettes
Status: RECRUITING
Conditions: Nicotine Dependence|Electronic Cigarette Use
Interventions: DRUG: Electronic Cigarette|DRUG: Nicotine Lozenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Electrical Stimulation to Strengthen Muscles in the Lower Legs in Patients Requiring Prolonged Mechanical Ventilation
Status: COMPLETED
Conditions: Muscle Weakness
Interventions: DEVICE: Neuromuscular electrical stimulation|DEVICE: sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Open-label, Multi-center Pilot Study to Evaluate the Safety, Feasibility and Usability of the IDA
Status: UNKNOWN
Conditions: Chronic Kidney Disease Stage V
Interventions: DEVICE: Inteligent Dialysis Assistant (IDA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ITIL-168 in Advanced Solid Tumors
Status: WITHDRAWN
Conditions: Cervical Cancer|Head and Neck Squamous Cell Carcinoma|Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: ITIL-168
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myofascial Stretch With And Without Functional Massage In Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy, Functional Massage, Myofacial Stretch
Interventions: OTHER: Myofascial stretch|OTHER: Functional massage along with myofacial stretch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Nutritional Improvement in Chronic Heart Failure Patients
Status: COMPLETED
Conditions: Heart Failure
Interventions: DIETARY_SUPPLEMENT: Hypercaloric beverages|OTHER: standard treatment|OTHER: educational structured counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TRI-V Heart Failure (HF) Implanted Cardioverter Defibrillator (ICD) Study
Status: COMPLETED
Conditions: Heart Failure
Interventions: DEVICE: Device Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety, Tolerability and Efficacy of Ezetimibe on a Select Population of Filipinos With Hypercholesterolemia (Study P04748)(COMPLETED)
Status: COMPLETED
Conditions: Primary Hypercholesterolemia|Homozygous Familial Hypercholesterolemia
Interventions: DRUG: Ezetimibe
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of LMWH Versus Rivaroxaban in Chinese Patients Hospitalized With Acute Coronary Syndrome
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Myocardial Infarction|Myocardial Ischemia|Unstable Angina
Interventions: DRUG: Rivaroxaban 2.5 mg|DRUG: Rivaroxaban 5 mg|DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of Single IV Dose of HSK3486 Injectable Emulsion in Healthy Subjects.
Status: COMPLETED
Conditions: Anesthesia|Sedation
Interventions: DRUG: HSK3486
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biodistribution and Safety of the PET Probes [18F]FPRGD2 and [18F]FPPRGD2
Status: COMPLETED
Conditions: Breast Cancer|Non-Small-Cell Lung Cancer|Glioblastoma|Other Cancers
Interventions: DRUG: F18-FPPRGD2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: TGRX-326 Chinese Phase III for Advanced Non-small Cell Lung Cancer (NSCLC)
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: TGRX-326|DRUG: Crizotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impacts of Oral Irrigation in Patients With Periimplant Mucositis
Status: COMPLETED
Conditions: Peri-implant Mucositis
Interventions: DIAGNOSTIC_TEST: Periimplant crevicular fluid (PICF) collection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Reversal of Heparin in Patients Undergoing Percutaneous Coronary Intervention (PCI)
Status: TERMINATED
Conditions: Percutaneous Coronary Intervention|Coronary Artery Disease (CAD)|Angioplasty
Interventions: DRUG: PMX-60056
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Pharmacokinetic-pharmacodynamic Change of Rocuronium After Reperfusion of Renal Graft
Status: RECRUITING
Conditions: End Stage Renal Disease|Transplantation
Interventions: DRUG: Rocuronium bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Duration of Antibiotic Therapy for Early (DATE) Ventilator Associated Pneumonia (VAP): 4 vs. 7 Days
Status: RECRUITING
Conditions: Ventilator Associated Pneumonia
Interventions: DRUG: Standard of Care Antibiotic Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Compared to Ondansetron for Postanaesthetic Shivering in Patients Undergoing a Cesarean Section
Status: COMPLETED
Conditions: Postanesthetic Excitement|Cesarean Section
Interventions: DRUG: saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Improved Prostate Cancer Diagnosis - Combination of Magnetic Resonance Imaging and Biomarkers
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DEVICE: 3T MRI (Magnetom Verio 3T, Erlangen, Germany)|DEVICE: Transrectal ultrasound (Bk Medical Pro Focus Ultraview 2202 system)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Obesity on Rectus Femoris Muscle Thickness, Sarcopenia, Gait and Balance in Women
Status: ENROLLING_BY_INVITATION
Conditions: Sarcopenic Obesity|Sarcopenia|Obesity
Interventions: DIAGNOSTIC_TEST: Ultrasonografi, Sarcopenia measurement, Zebris
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Three-part Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of MK-2640 in Healthy Participants (Part I) and Participants With Type 1 Diabetes Mellitus (Parts II and III) (MK-2640-001)
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: MK-2640|BIOLOGICAL: Regular Human Insulin (RHI)|DRUG: Dextrose|BIOLOGICAL: Insulin aspart|DRUG: Rescue medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CBT for Patients With Attention Deficit Hyperactivity Disorder (ADHD) and Substance Use Disorders
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder|Substance Use Disorders
Interventions: BEHAVIORAL: cognitive behavioral therapy for treating ADHD symptoms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total Lymphoid Irradiation (TLI) to Prevent Focal Segmental Glomerulosclerosis (FSGS)Recurrence in the Renal Graft
Status: COMPLETED
Conditions: Glomerulosclerosis, Focal
Interventions: PROCEDURE: Total Lymphoid irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Dexamethasone for Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy
Status: RECRUITING
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Dexamethasone Oral|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ultrasound Guided Ulnar Versus Radial Artery in Pediatrics Undergoing Major Non Cardiac Surgery
Status: COMPLETED
Conditions: Anesthesia|Pediatrics|Radial Artery|Ulnar Artery
Interventions: PROCEDURE: ultrasound guided radial versus ulnar artery cannulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Fludarabine|DRUG: Cytarabine|DRUG: Gemtuzumab Ozogamicin|DRUG: Azacitidine|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of NeuroSpan Bridge, NeuraGen Nerve Guide, and Nerve Autograft for Peripheral Nerve Repair
Status: NOT_YET_RECRUITING
Conditions: Peripheral Nerve Injuries
Interventions: DEVICE: NeuroSpan Bridge|DEVICE: NeuroGen Nerve Guide|DEVICE: Nerve Autograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing 3 New Formulations of Premarin® 0.625 mg/MPA 2.5 mg With a Reference Formulation
Status: COMPLETED
Conditions: Menopause
Interventions: DRUG: Premarin®/MPA formulation A|DRUG: Premarin®/MPA formulation B|DRUG: Premarin®/MPA formulation C|DRUG: Premarin®/MPA currently marketed product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: MUA to Treat Postoperative Stiffness After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Stiffness Following Total Knee Arthroplasty
Interventions: DRUG: Dexamethasone|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-Human Trial in Healthy Adult Volunteers to Evaluate Safety, Tolerability and PK of LAPIX Study Drug; LPX-TI641
Status: RECRUITING
Conditions: Autoimmune Diseases|Multiple Sclerosis
Interventions: DRUG: LPX-TI641
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumors|Metastatic Solid Tumors
Interventions: DRUG: GDC-1971|DRUG: Atezolizumab|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of HX575 Hexal AG vs ERYPO® for the Treatment of Anemia in Hemodialysis Patients
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: HX575 epoetin alfa Hexal AG|DRUG: ERYPO®, Janssen-Cilag
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics and Efficacy Study of CVT-301 Inpatients With Parkinson's Disease and "Off" Episodes
Status: COMPLETED
Conditions: Idiopathic Parkinson's Disease
Interventions: DRUG: CVT-301|DRUG: Placebo|DRUG: Sinemet (carbidopa/levodopa)|DRUG: CVT-301
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy of Homeopathic Medicine Rhus Toxicodendron 30 in the Treatment of Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis.
Interventions: DRUG: Rhustoxicodendron 30|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-54861911 in Healthy Elderly Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-54861911 3 mg|DRUG: JNJ-54861911 10 mg|DRUG: JNJ-54861911 30 mg|DRUG: JNJ-54861911 80 mg|DRUG: JNJ-54861911 25 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Acthar in Subjects With ARDS
Status: WITHDRAWN
Conditions: Acute Respiratory Distress Syndrome
Interventions: DRUG: H.P. Acthar® Gel (repository corticotropin injection)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of Etravirine for HIV-infected Patients in Need of Lipid-lowering Drugs
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: stop statin and switch to an antiretroviral drug with less impact on lipid metabolism
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ASAP: Access to Syringes at Pharmacies for the Prevention of Bloodborne Infections Among People Who Inject Drugs
Status: COMPLETED
Conditions: Skin and Soft Tissue Infections|Hiv|Hepatitis C|Bloodstream Infection
Interventions: BEHAVIORAL: ASAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Intranasal Octreotide (DP1038) in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer Study
Interventions: DRUG: Intranasal octreotide acetate|DRUG: Subcutaneous octreotide acetate|DIAGNOSTIC_TEST: Growth hormone-releasing hormone|DIAGNOSTIC_TEST: Arginine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Functional MRI Study of Vibrotactile Stimulation Effects in Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: Vibrotactile stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mentalization Based Treatment - Introductory (MBT-I) Group for Male Prisoners With Borderline and/or Antisocial Personality Disorder
Status: UNKNOWN
Conditions: Borderline Personality Disorder (BPD)|Antisocial Personality Disorder (ASPD)
Interventions: OTHER: Mentalization Based Treatment-Introductory|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Adaptive Treatment for Alcohol and Cocaine Dependence
Status: COMPLETED
Conditions: Substance Use Disorders
Interventions: BEHAVIORAL: Motivational Interviewing|BEHAVIORAL: Telephone counseling|BEHAVIORAL: Cognitive Behavioral Therapy (CBT) Counseling|DRUG: medication management|BEHAVIORAL: Intensive OutPatient Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Personalised Radiosurgery Procedure for People With Trigeminal Neuralgia to Improve Pain, Quality of Life and Reduce Complications
Status: RECRUITING
Conditions: Trigeminal Neuralgia|Multiple Sclerosis|Pain
Interventions: PROCEDURE: Gamma Knife Radiosurgery (GKRS) personalised procedure|PROCEDURE: GKRS standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Famitinib in Treating Patients With Recurrent and/or Metastatic Nasopharyngeal Carcinoma (NPC)
Status: COMPLETED
Conditions: Recurrent Nasopharyngeal Carcinoma|Metastatic Nasopharyngeal Carcinoma
Interventions: DRUG: Famitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Location Initiated Individualized Texts for Adolescent Health (LIITAH)
Status: COMPLETED
Conditions: Overweight|Obese|Healthy
Interventions: OTHER: Full version of the LIITah App.|OTHER: Partial App. (ELI and SNAP only)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Tolerability of Andecaliximab as Monotherapy and in Combination With Anti-Cancer Agents in Japanese Participants With Gastric or Gastroesophageal Junction Adenocarcinoma
Status: TERMINATED
Conditions: Gastric Adenocarcinoma
Interventions: DRUG: Andecaliximab|DRUG: S-1|DRUG: Cisplatin|DRUG: Oxaliplatin|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Early and Late Loading in the Edentulous Upper Jaw Using Cresco Prosthetic System on Straumann Implants
Status: COMPLETED
Conditions: Jaw, Edentulous
Interventions: DEVICE: Cresco|DEVICE: Cresco|DEVICE: Straumann components
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET Imaging of Cancer Patients Using [18F]-SKI-249380, a Radiolabeled Dasatinib-Derivative
Status: COMPLETED
Conditions: Carcinoma|Sarcoma|Myeloma|Lymphoma|Melanoma
Interventions: RADIATION: [18F]-SKI-249380|PROCEDURE: PET/CT scan|OTHER: Blood draws
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Test MK-0941 in Patients With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin (MK-0941-017)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: MK-0941|DRUG: Glimepiride|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CET- REM (Correlating ECT Response to EEG Markers)
Status: ACTIVE_NOT_RECRUITING
Conditions: ECT|Treatment Resistant Depression
Interventions: DIAGNOSTIC_TEST: Electroencephalographic (EEG)|DIAGNOSTIC_TEST: Closed loop acoustic stimulation (CLAS)|DIAGNOSTIC_TEST: Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR16)|DIAGNOSTIC_TEST: Ictal Electroencephalographic (EEG) Measurements|DIAGNOSTIC_TEST: Post-Ictal Electroencephalographic (EEG) Suppression Measurements|DIAGNOSTIC_TEST: Quantitative Measurements of Sleep Microstructure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioequivalence Study of Ropinirole Hydrochloride CR 2mg Tablets of Lupin Limited, India, With REQUIP XL of GlaxoSmithKline Research Triangle Park, in Healthy, Adult, Male, Subjects Under Fasting Conditions
Status: COMPLETED
Conditions: Pharmacokinetic Study
Interventions: DRUG: Ropinirole hydrochloride CR Tablets 2mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Study of Acne Treatment in Children Ages 9 to 11
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Retin-A Micro 0.04% facial acne treatment|DRUG: Vehicle control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Chinese People With Overweight or Obesity to Test How Different Doses of Survodutide Are Taken up in the Body
Status: RECRUITING
Conditions: Overweight|Obesity
Interventions: DRUG: survodutide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parathyroid Hormone Levels in Relation to the Phosphorus Content of Meals
Status: COMPLETED
Conditions: Renal Failure
Interventions: DRUG: calcium acetate|DRUG: aluminum hydroxide|DRUG: Sevelamer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: PREVENTION
Clinical trial: The Effectiveness of Different Techniques of Interscalene Brachial Plexus Block With General Anesthesia for Shoulder Arthroscopy
Status: COMPLETED
Conditions: Shoulder and Upper Arm Injury
Interventions: DEVICE: ultrasound and nerve stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Defining Decision Thresholds for Judgments on Health Benefits and Harms: Study Protocol
Status: UNKNOWN
Conditions: Decision Support Techniques|GRADE Approach
Interventions: OTHER: descriptive case-scenarios
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Edema Control in Patients With Breast Cancer-comparison of Manual Lymph Drainage and Epidermis Fascia Taping
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: OTHER: self massage|OTHER: manual lymph drainage|OTHER: epidermis fascia taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Polymorphism of Heat Shock Protein 70 Gene and Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: GENETIC: Polymorphisms of HSP70 and TNF promoter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Prasugrel on Platelets After One Week in Patients Already Taking Clopidogrel After a Cardiac Event
Status: COMPLETED
Conditions: Coronary Arteriosclerosis|Acute Coronary Syndrome
Interventions: DRUG: prasugrel 10 mg|DRUG: clopidogrel|DRUG: prasugrel placebo|DRUG: prasugrel 60 mg|DRUG: clopidogrel placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Progesterone Action on Endometrium of PCOS
Status: COMPLETED
Conditions: Polycystic Ovary|Progesterone Resistance
Interventions: DRUG: Progesterone 400 Mg Vaginal Suppository on PCOS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Azelaic Acid Foam, 15% in Papulopustular Rosacea
Status: COMPLETED
Conditions: Papulopustular Rosacea
Interventions: DRUG: Azelaic acid foam 15%|DRUG: Vehicle foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Hypertension in Extremely Preterm Infants
Status: NOT_YET_RECRUITING
Conditions: Bronchopulmonary Dysplasia|Pulmonary Hypertension|Premature Birth
Interventions: DIAGNOSTIC_TEST: Echocardiography|DIAGNOSTIC_TEST: NT-proBNP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Assessment of Inhibition of Biofilm Formation and Plaque Bacterial Count of Fluoride Varnish Containing Chlorhexidine and Cetylpyridinium Chloride Versus Conventional Fluoride Varnish
Status: UNKNOWN
Conditions: High Caries Risk Patients
Interventions: DRUG: Cervitec F, Ivoclar Vivadent - Schaan Liechtenstein|DRUG: Fluor Protector, Ivoclar Vivadent - Schaan Liechtenstein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Observational Study of Cisatracurium 0.15 mg/kg in Young and Elderly (≥ 80 Years) Patients.
Status: COMPLETED
Conditions: Onset Time of Cisatracurium|Duration of Action of Cisatracurium|Intubation Conditions
Interventions: DRUG: Cisatracurium
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open Labelled, Randomized Study to Evaluate the Efficacy, Safety and Dose Selection of VM-1500A-LAI Drug in HIV-infected Patients Transferred From Previous Stable Therapy (NNRTI + 2NRTI), Including ELPIDA®
Status: COMPLETED
Conditions: HIV-1-infection
Interventions: DRUG: VM-1500A-LAI|OTHER: ELPIDA®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Camrelizumab Combined With Apatinib Mesylate and Standard Chemotherapy (Pemetrixed + Carboplatin) in Patients With Tyrosine Kinase Inhibitor Failure in ALK-positive Advanced NSCLC
Status: NOT_YET_RECRUITING
Conditions: Lung Neoplasms
Interventions: DRUG: Camrelizumab|DRUG: Apatinib|DRUG: Pemetrixed|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Protocol for the Safety and Tolerance of Intravenous Isophosphoramide Mustard (IPM) in Patients With Advanced Cancer
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: DRUG: ZIO-201
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2, Open-Label, Dose-Escalation Study of JI-101, in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: JI-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can we Antagonize Mivacurium With Neostigmine ?
Status: COMPLETED
Conditions: Mivacurium|Neostigmine|Residual Paralysis
Interventions: DRUG: Neostigmine (40 mcg / kg) at different time of neuromuscular block's recovery|OTHER: Spontaneous recovery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Steroids in Patients With Early ARDS
Status: UNKNOWN
Conditions: Acute Lung Injury|ARDS, Human
Interventions: DRUG: Methylprednisolone|OTHER: Normal saline intravenously and vitamin B1 per os
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cefdinir Capsules 300 mg, Non-fasting
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cefdinir Capsules 300 mg|DRUG: OMNICEF® Capsule 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Imaging Versus Cardiac Biomarker Monitored HER2 Directed Therapy in Patients With Breast Cancer
Status: RECRUITING
Conditions: Cardiotoxicity|HER2-positive Breast Cancer
Interventions: DIAGNOSTIC_TEST: Biomarkers: Troponins and natriuretic peptides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Quantitative and Qualitative Study of the Determinants of Participation in a Cytomegalovirus Preventive Vaccine Study in France in Women Aged 18 to 40 Years Old.
Status: NOT_YET_RECRUITING
Conditions: Recruitment
Interventions: OTHER: Qualitative interview|OTHER: Quantitative questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Applied Topical Heat as an Adjunct for Pain Control in First-Trimester Surgical Abortionl
Status: COMPLETED
Conditions: Topical Heat Application for Intraoperative Abortion Pain Management
Interventions: OTHER: heat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the MASEI in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis
Status: COMPLETED
Conditions: Spondyloarthropathy
Interventions: DRUG: 50mg etanercept|DRUG: 25mg etanercept|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single-dose Pharmacokinetics of BMS-626529, Administered as BMS-663068, in Subjects With Hepatic Impairment Compared to Healthy Subjects
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: BMS-663068
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Serplulimab With Chemotherapy and Aspirin in Untreated Extensive-Stage Small Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Extensive-Stage Small Cell Lung Cancer|Treatment-naïve for Systemic Therapy Targeting Extensive-Stage Small Cell Lung Cancer|ECOG Performance Status Score of 0 or 1|Expected Survival ≥3 Months
Interventions: DRUG: Serplulimab，Platinum-based Chemotherapy，Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: JUMP Prevalence of Sarcopenia and Chemobrain in Post-cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer|Sarcopenia
Interventions: DRUG: Study of the adverse effects of long-term oncological treatments|BEHAVIORAL: Study of the long-term side effects of oncological treatments on the anxiety-depressive and cognitive state of patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized, Double-Blind, Single Center, Efficacy and Safety Study of Allogeneic HB-adMSCs Against COVID-19.
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: HB-adMSCs|OTHER: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of LMA Proseal and LMA Supreme for Efficient Ventilation During Lateral Positioned Laparoscopic Surgeres
Status: COMPLETED
Conditions: Urologic Surgical Procedures
Interventions: DEVICE: LMA Proseal|DEVICE: LMA Supreme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Acute Exercise and NK Cell Regulation in Tissue and Circulation After IL-6R Blockade
Status: COMPLETED
Conditions: Interleukin-6 Inhibition|Physical Stress|Appetitive Behavior
Interventions: DRUG: Tocilizumab Injectable Product|OTHER: Saline 0.9% 100 ml NaCl 0.9% will be infused over 1 hour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cooking for Health Optimization With Patients
Status: COMPLETED
Conditions: Cardiovascular Diseases|Cardiovascular Risk Factor|Nutrition Disorders|Diabetes|Hypertension|Cancer|Depression|Obesity|Physical Activity
Interventions: BEHAVIORAL: Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Powered-Knee Exoskeleton Assist on Stair Climbing in Acute CVA
Status: COMPLETED
Conditions: Stroke, Acute|Gait Disorders, Neurologic
Interventions: DEVICE: Keeogo|OTHER: Traditional Stair Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Milk in Preterm Infants
Status: UNKNOWN
Conditions: Preterm Birth
Interventions: DIETARY_SUPPLEMENT: Human milk fortifier
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TINN Pharmacokinetics (PK) Study Treat Infections iN Neonates
Status: COMPLETED
Conditions: Pharmacokinetics of Ciprofloxacin in Neonates
Interventions: PROCEDURE: Collection of biological samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessment of Combined CCM and ICD Device in HFrEF
Status: RECRUITING
Conditions: Heart Failure|Heart Failure with Reduced Ejection Fraction|Implantable Defibrillator User|CCM Therapy|Non-ischemic Cardiomyopathy|Ischemic Cardiomyopathy|Sudden Cardiac Arrest|Arrhythmias, Cardiac|Ventricular Tachycardia|Ventricular Fibrillation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of GOS Supplementation on Amoxicillin-treated Gut Microbiota From Healthy Adults
Status: COMPLETED
Conditions: Colonic Diseases [C06.405.469.158]
Interventions: DIETARY_SUPPLEMENT: GOS addition|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Research Study Looking at How Safe Somapacitan is and How Well it Works in Children Who Need Help to Grow - REAL 9
Status: RECRUITING
Conditions: SGA|Turner Syndrome|Noonan Syndrome|ISS
Interventions: DRUG: Somapacitan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Targeted, Real-Time, Technology-Supported Intervention for Patients With Alcohol Use Disorder on Disulfiram
Status: COMPLETED
Conditions: Drinking, Alcohol
Interventions: BEHAVIORAL: Wisepill+SMS|OTHER: Wisepill-only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Balance and Gait Weight Distribution in Patients With Vertebral Column Fractures
Status: UNKNOWN
Conditions: Vertebral Fracture|Balance|Gait, Unsteady
Interventions: DEVICE: Zebris Gait System assessment for gait weight distribution + EMG evaluation of Quadriceps, Hamstrings, Tib Anterior and Calves + Positional Sense assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial to Demonstrate the Safety and Efficacy of DUOFAG®
Status: RECRUITING
Conditions: Surgical Site Infection|Staphylococcus Aureus Infection|Pseudomonas Aeruginosa Infection|Bacterial Infections|Surgical Wound Infection
Interventions: DRUG: IMP|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multiple Ascending Dose Study of Pegozafermin in Participants With Biopsy Confirmed Nonalcoholic Steatohepatitis (NASH) or Nonalcoholic Fatty Liver Disease (NAFLD) and at High Risk of NASH
Status: COMPLETED
Conditions: NASH
Interventions: DRUG: Pegozafermin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Faecal Microbiota Transplantation in Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis|Inflammatory Bowel Disease
Interventions: BIOLOGICAL: FMT infusions|OTHER: Placebo infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Zoledronic Acid in Enhancement of Early Stability of Cementless Primary Hip Prosthesis
Status: COMPLETED
Conditions: Hip Osteoarthritis
Interventions: DRUG: zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Convalescent Plasma vs. Standard Plasma for COVID-19
Status: TERMINATED
Conditions: COVID
Interventions: BIOLOGICAL: Convalescent Plasma|BIOLOGICAL: Standard Donor Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-blind, Placebo-controlled, Multicenter Study of the Effects of Glatiramer Acetate (GA) on the Retinal Nerve Fiber Layer (RNFL) and Visual Function in Patients With a First Episode of Acute Optic Neuritis (AON). (Octagon)
Status: COMPLETED
Conditions: Optic Neuritis
Interventions: DRUG: Glatiramer Acetate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness Therapy on Disrupted Sleep in Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder|Insomnia|Hypersomnia|Sleep Problems
Interventions: BEHAVIORAL: Body Scan (BS) Meditation Intervention|BEHAVIORAL: Brief Supportive Psychotherapy (SP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prognosis of Coronavirus Disease 2019 (COVID-19) Patients Receiving Receiving Antihypertensives
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Angiotensin-Converting Enzyme Inhibitors (ACE-I) and Angiotensin II Receptor Blockers (ARB)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Atorvastatin Versus Simvastatin In The Prevention Of Coronary Heart Disease (CHD) In Patients With Known CHD
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DRUG: atorvastatin|DRUG: simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of QR-333 in Patient's With Symptomatic Diabetic Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathy
Interventions: DRUG: QR-333
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anlotinib Hydrochloride Combined With EGFR-Tyrosine Kinase Inhibitor (TKI) in Treating Advanced NSCLC Patients With Acquired Resistance to EGFR-TKI
Status: UNKNOWN
Conditions: NSCLC
Interventions: DRUG: Anlotinib Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zibotentan, an Endothelin Receptor Antagonist, Patients With Intermittent Claudication
Status: COMPLETED
Conditions: Peripheral Arterial Disease|Intermittent Claudication
Interventions: DRUG: Zibotentan (ZD4054)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Albumin Versus Routine Care on Hemodynamic Response and Stability in Patients With Preeclampsia Guided by a Non-invasive Hemodynamic Monitoring System During Cesarean Delivery With Spinal Anesthesia
Status: NOT_YET_RECRUITING
Conditions: Pre-Eclampsia
Interventions: DRUG: Human Albumin (colloid)|DRUG: Lactated Ringer's Injection (crystalloid)|DEVICE: Edwards HemoSphere monitor with ClearSight-Acumen finger cuff
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Laparoscopic Primary Diaphragm Versus Mesh Repair for Hiatus Hernia: a Long-Term Follow-Up
Status: NOT_YET_RECRUITING
Conditions: Hernia, Hiatal|Laparoscopic|Surgery|Recurrence|Mesh|Primary
Interventions: DEVICE: Mesh repair|PROCEDURE: Suture repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: MRI-based Synthetic CT Images of the Head and Neck
Status: COMPLETED
Conditions: Imaging of Bony Structures of the Head (Various Conditions)|Hearing Loss|Cholesteatoma|Sinusitis|Head and Neck Tumor
Interventions: DIAGNOSTIC_TEST: CT scan|DIAGNOSTIC_TEST: MRI scan|OTHER: Synthetic CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pilot Trial of "My Meal Mate" (MMM), a Smartphone Application for Weight Loss
Status: COMPLETED
Conditions: Obesity|Overweight
Interventions: BEHAVIORAL: "My Meal Mate" (smartphone application)|BEHAVIORAL: Paper food diary|BEHAVIORAL: Online food diary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Pistachios on Cardiovascular Responses to Stress in Type 2 Diabetes
Status: COMPLETED
Conditions: Cardiovascular Disease|Type 2 Diabetes
Interventions: OTHER: Pistachio
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Parecoxib for Treatment of Catheter Related Bladder Discomfort
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Parecoxib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase Il of a Therapeutic, Recombinant, Biologically Active HIV-1 Tat Protein Vaccine in HIV-Infected, Anti-Tat Negative, ARV-Treated Adult Volunteers
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: Tat|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Dynamic Splinting on Knee Flexion Angle After Total Knee Arthroplasty: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Acquired Fixed Flexion Deformity of the Knee (Disorder)
Interventions: DEVICE: Knee flexion Dynasplint orthosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect Of Fluconazole On Pharmacokinetics Of Fesoterodine In Healthy Subjects
Status: COMPLETED
Conditions: Overactive Bladder With Symptoms of Frequency, Urgency, and Urge Urinary Incontinence
Interventions: DRUG: Fesoterodine|DRUG: fesoterodine plus fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT