pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety/Efficacy of Intravenous Zoledronic Acid When Added to Standard Therapies in Patients With Breast Cancer and Metastatic Bone Lesions
Status: TERMINATED
Conditions: Breast Cancer With Bone Metastasis
Interventions: DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exclusive Enteral Nutrition in Preterm Neonates
Status: ACTIVE_NOT_RECRUITING
Conditions: Premature; Infant, Light-for-dates|Enteral Feeding Intolerance
Interventions: PROCEDURE: Exclusive Enteral Nutrition|PROCEDURE: Progressive Enteral Nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pilot Project on the Automatic Design and 3D Printing of Adolescent Idiopathic Scoliosis Braces (Phase 1)
Status: NOT_YET_RECRUITING
Conditions: Adolescent Idiopathic Scoliosis
Interventions: DEVICE: Test Brace
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MK0663/Etoricoxib for Post-Abdominal Hysterectomy Surgery Pain (0663-097)(COMPLETED)
Status: COMPLETED
Conditions: Acute Pain Following a Total Abdominal Hysterectomy
Interventions: DRUG: etoricoxib (MK0663) 120 mg|DRUG: Comparator: Placebo|DRUG: etoricoxib (MK0663) 90 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Trastuzumab Administration in Metastatic Breast Cancer Patients Developing Carcinomatous Meningitis
Status: COMPLETED
Conditions: Metastatic Breast Cancer|Carcinomatous Meningitis
Interventions: DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study to Evaluate the Effect of GFT505 on QT/QTc Interval in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Placebo|DRUG: GFT505|DRUG: Moxifloxacin 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 Combined With Immune Therapies in Advanced or Metastatic Malignancies
Status: COMPLETED
Conditions: Advanced Malignancies|Metastatic Cancer
Interventions: DRUG: INCAGN01876|DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I of Histone Deacetylase (HDAC) Inhibitor Panobinostat With Ipilimumab With Unresectable III/IV Melanoma
Status: COMPLETED
Conditions: Melanoma|Skin Cancer
Interventions: DRUG: Panobinostat|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Musculoskeletal Complaints in Nursing Home Residents
Status: RECRUITING
Conditions: Rheumatoid Arthritis|Rheumatic Diseases|Musculoskeletal Diseases|Musculoskeletal Diseases or Conditions|Gout|Degenerative Joint Disease|Orthopedic Disorder|Arthritis|Polyarthritis|Musculoskeletal Pain|Arthrosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Activity of Lorlatinib Based on ALK Resistance Mutations Detected on Blood in ALK Positive NSCLC Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Lorlatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib in Treating Patients With Unresectable Locally Advanced or Metastatic Adenocarcinoma of the Bile Duct or Gallbladder
Status: TERMINATED
Conditions: Adenocarcinoma of the Extrahepatic Bile Duct|Adenocarcinoma of the Gallbladder|Advanced Adult Primary Liver Cancer|Gastrointestinal Cancer|Localized Unresectable Adult Primary Liver Cancer|Recurrent Adult Primary Liver Cancer|Recurrent Extrahepatic Bile Duct Cancer|Recurrent Gallbladder Cancer|Unresectable Extrahepatic Bile Duct Cancer|Unresectable Gallbladder Cancer
Interventions: DRUG: bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Muscle Impact of Treating Osteoporosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Sarcopenia|Osteoporosis
Interventions: DRUG: Denosumab|DRUG: Zoledronic Acid|OTHER: Denosumab Placebo|OTHER: Zoledronic Acid Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cranial Nerve Neuromodulation to Improve Arm Function and Brain Plasticity in Stroke
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: PROCEDURE: Strength training|PROCEDURE: Cranial nerve non-invasive neuromodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Prevention of Recurrent Gastric or Duodenal Ulcers Caused by Low-dose Aspirin With Rabeprazole (E3810) Treatment (Planetarium Study)
Status: COMPLETED
Conditions: Gastric Ulcers Duodenal Ulcers Caused by Low-dose Aspirin
Interventions: DRUG: Rabeprazole|DRUG: Rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Screening of Susceptibility Genes for APAP Induced Drug Induced LIver Injury in ChiNese Population: a Case-control Study
Status: RECRUITING
Conditions: Acetaminophen|Drug-Induced Liver Injury|Pharmacogenetics|China
Interventions: GENETIC: genetic polymorphism
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of TSC-100 and TSC-101 in AML, ALL and MDS Patients Undergoing Haploidentical Donor Transplantation
Status: RECRUITING
Conditions: AML|Myelodysplastic Syndromes|ALL, Adult
Interventions: DRUG: SOC + TSC-100|DRUG: SOC + TSC-101|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Osteoporosis Education Effective in Parkinsonian Patients
Status: COMPLETED
Conditions: Osteoporosis|Parkinson Disease
Interventions: BEHAVIORAL: Providing structured osteoporosis education|BEHAVIORAL: Giving informative leaflet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cognis and Teligen 100 HE and Reliance Quadripolar Defibrillation Lead (4-Site) Field Following
Status: COMPLETED
Conditions: Ventricular Tachycardia, Ventricular Fibrillation|Heart Failure
Interventions: DEVICE: Cognis 100-D, Teligen DR, VR 100 HE
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety Evaluation of the ReWalk ReStore Device in Subjects With Mobility Impairments Due to Stroke
Status: UNKNOWN
Conditions: Stroke|Stroke, Acute|Stroke Hemorrhagic|Hemiparesis|Hemiplegia|Cerebrovascular Accident
Interventions: DEVICE: ReWalk ReStore device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Qinbudan as an Adjunct Therapy for Retreatment Pulmonary Tuberculosis
Status: COMPLETED
Conditions: Pulmonary Tuberculosis
Interventions: DRUG: Qinbudan|DRUG: Qinbudan Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Treatment of Common Bile Duct Stones : What Are the Limits and When Should we Call the Endoscopist ?
Status: COMPLETED
Conditions: Laparoscopic|Common Bile Duct Stone With Chronic Cholecystitis
Interventions: PROCEDURE: Laparoscopic common bile duct exploration.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Integrated Primary Care for Diabetes and Cardiovascular Disease
Status: UNKNOWN
Conditions: Diabetes Mellitus|Hypertension|Heart Failure|Ischemic Heart Disease|Cerebrovascular Disease
Interventions: BEHAVIORAL: Outreach education training|BEHAVIORAL: No outreach education training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pulsed Lavage in Implant-Based Breast Reconstruction
Status: RECRUITING
Conditions: Breast Reconstruction
Interventions: OTHER: Pulsed Lavage Washout|PROCEDURE: Implant-based breast reconstruction|PROCEDURE: Bilateral or unilateral mastectomy|DEVICE: Tissue expander|OTHER: Acellular dermal matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Primary Anterior Cruciate Ligament Repair With and Without Lateral Extraarticular Tenodesis
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Tear
Interventions: PROCEDURE: Primary anterior cruciate ligament repair|PROCEDURE: Primary anterior cruciate ligament repair and lateral extraarticular tenodesis (LET) with iliotibial band
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of CHS-0214 to Enbrel (Etanercept) in Patients With Chronic Plaque Psoriasis (PsO)
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Etanercept|DRUG: CHS-0214
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Different Types of Mesh for Prevention of Incisional Hernia Versus Primary Abdominal Suturing
Status: UNKNOWN
Conditions: Incisional Hernia
Interventions: PROCEDURE: prophylactic mesh repair at different sites for prevention of incisional hernia after various abdominal incision versus primary abdominal suturing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating The Efficacy And Safety Of Bapineuzumab In Alzheimer Disease Patients
Status: TERMINATED
Conditions: Alzheimer Disease
Interventions: DRUG: bapineuzumab|DRUG: bapineuzumab|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Acceptability of SPL7013 Gel (VivaGel™) in Sexually Active Women
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 3% SPL7013 Gel (VivaGel)|DRUG: Placebo Gel|DRUG: HEC Placebo Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Efficacy and Outcome Study of Supplemental Oxygen Treatment in Patients With Suspected Myocardial Infarction
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Non-ST Elevation (NSTEMI) Myocardial Infarction|Acute ST Segment Elevation Myocardial Infarction|Angina, Unstable
Interventions: DRUG: Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial of a Novel Community-based Primary and Secondary Cardiovascular Prevention Program
Status: COMPLETED
Conditions: Vascular Disease|Diabetes|Hypertension|Hyperlipidemia|Obesity
Interventions: BEHAVIORAL: Action Score|BEHAVIORAL: VIP program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Remimazolam and Remifentanil Without Neuromuscular Blocking Agent
Status: COMPLETED
Conditions: Myoma;Uterus|Polyp Endometrium|Unspecified Condition Associated With Female Genital Organs and Menstrual Cycle
Interventions: DRUG: Remimazolam
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Solyx Single-Incision SlingDynamic Intraoperative Standing Sling Technique (DISST) as an Office-based Procedure
Status: ACTIVE_NOT_RECRUITING
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: Single-Incision Sling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Augmenting Atropine Treatment for Amblyopia in Children 3 to < 8 Years Old
Status: COMPLETED
Conditions: Amblyopia
Interventions: DRUG: Atropine|DEVICE: Plano lens|DRUG: Atropine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lateral Postural Inclination in Parkinson's Disease : Involvement of the Basal Ganglia ?
Status: TERMINATED
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: Subthalamic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: B-Lynch Transverse Compression Suture Versus a Sandwich Technique (N&H Technique) for Complete Placenta Previa
Status: UNKNOWN
Conditions: Cesarean Section Complications
Interventions: PROCEDURE: stepwise devascularization|PROCEDURE: B-Lynch Transverse Compression Suture group|PROCEDURE: N&H sandwich technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Spironolactone in Adult Congenital Heart Disease
Status: COMPLETED
Conditions: Congenital Heart Disease|Heart Failure|Endomyocardial Fibrosis
Interventions: DRUG: Spironolactone 25mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neuropathic Pain Syndrome Patient Study (MK-0000-072)
Status: COMPLETED
Conditions: Neuralgia, Postherpetic|Diabetic Neuropathy|Painful Small-Fiber Neuropathy|Idiopathic Distal Sensory Polyneuropathy
Interventions: DRUG: Comparator: pregabalin|DRUG: Comparator: Placebo (unspecified)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Genotypic Tropism Testing In Proviral Dna To Guide CCR5 Antagonist Treatment In Subjects With Undetectable HIV-1 Viremia
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Unique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of Trauma Therapy in Patients With PTSD and Comorbid Psychotic Disorder
Status: RECRUITING
Conditions: Post Traumatic Stress Disorder|Psychotic Disorders|Psychosis|Schizophrenia|PTSD
Interventions: BEHAVIORAL: Prolonged Exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Modified Vacc-4x Gag Peptides With Endocine as Adjuvant
Status: COMPLETED
Conditions: HIV Infection
Interventions: BIOLOGICAL: Vacc-4x low dose|BIOLOGICAL: Vacc-4x medium dose|BIOLOGICAL: Vacc-4x high dose|BIOLOGICAL: Zero dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate Dose Proportionality of the Fixed Dose Combination of COREG CR and Lisinopril.
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: COREG CR and lisinopril (FDC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effects of Ultrasound-guided Dry-Needling Therapy for Neck and Head Pain
Status: SUSPENDED
Conditions: Neck Pain|Head Pain
Interventions: DEVICE: Ultrasound-guided Dry-Needling Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Mometasone Furoate Nasal Spray and Oxymetazoline Nasal Spray Given Together Once A Day To Treat Seasonal Allergic Rhinitis (P04500)
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: OXY combination: mometasone furoate nasal spray (MFNS) and oxymetazoline nasal spray (OXY)|DRUG: OXY combination: mometasone furoate nasal spray (MFNS) and oxymetazoline nasal spray (OXY)|DRUG: mometasone furoate nasal spray (MFNS) once daily|DRUG: oxymetazoline nasal spray (OXY) twice daily|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients
Status: COMPLETED
Conditions: Scoliosis|Pain
Interventions: DRUG: Methadone|OTHER: Normal Saline|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OASIS-HAE: A Study to Evaluate the Safety and Efficacy of Donidalorsen (ISIS 721744 or IONIS-PKK-LRx) in Participants With Hereditary Angioedema (HAE)
Status: COMPLETED
Conditions: Hereditary Angioedema
Interventions: DRUG: Donidalorsen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Innovative Methods to Reduce Emissions and Health Impacts of Deep-frying
Status: NOT_YET_RECRUITING
Conditions: Inflammation
Interventions: OTHER: Soybean oil + Roasted wheat flour|DIETARY_SUPPLEMENT: Fish oil + Roasted wheat flour|DIETARY_SUPPLEMENT: Soybean oil + Vegetable and fruit extracts|DIETARY_SUPPLEMENT: Fish oil + Vegetable and fruit extracts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Deep Transcranial Magnetic Stimulation (DTMS) as a Treatment for Attention Deficit Hyperactivity Disorder (ADHD) in Adults
Status: UNKNOWN
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DEVICE: treatment by HLPFC coil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Patidegib Topical Gel, 2%, for the Reduction of Disease Burden of Persistently Developing Basal Cell Carcinomas (BCCs) in Subjects With Basal Cell Nevus Syndrome (Gorlin Syndrome)
Status: COMPLETED
Conditions: Basal Cell Nevus Syndrome
Interventions: DRUG: Patidegib Topical Gel, 2%|DRUG: Patidegib Topical Gel, Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Two Different Regimens of Nolvadex in Preventing Gynecomastia Induced by Casodex 150 mg in Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Bicalutamide|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial to Assess Safety and Efficacy of Combination Therapy: Hydroxychloroquine, Pegylated Interferon Alpha-2a and Ribavirin in Chronic Hepatitis C Subjects Non-responders to the Standard of Care Therapy.
Status: UNKNOWN
Conditions: Chronic Hepatitis C
Interventions: BIOLOGICAL: Hydroxychloroquine (HCQ), Pegylated Interferon Alpha-2a (Peg-IFN alpha-2a) and Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Valsartan/Amlodipine As Compared to Losartan Treatment in Stage 2 Systolic Hypertension
Status: COMPLETED
Conditions: Stage 2 Systolic Hypertension
Interventions: DRUG: valsartan, amlodipine, HCTZ|DRUG: Losartan, HCTZ followed by valsartan, amlodipine, HCTZ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Infants With Newly Diagnosed Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Dose Escalation Study to Evaluate Safety and Pharmacokinetics (PK) of VX-840 in Healthy Participants
Status: COMPLETED
Conditions: APOL1-mediated Kidney Disease
Interventions: DRUG: VX-840|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Neuromuscular Electrical Stimulation (NMES) in Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Neuromuscular Electrical Stimlation (NMES)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placebo-Controlled Crossover Study to Evaluate Donepezil and MK-3134 for Reversal of Cognitive Impairment Associated With Scopolamine Administration (3134-005)(COMPLETED)
Status: COMPLETED
Conditions: Dementia
Interventions: DRUG: A: Placebo to match Donepezil and MK-3134 + Placebo to match Scopolamine|DRUG: B: Placebo to match Donepezil and MK-3134 + Scopolamine 0.5 mg|DRUG: C: MK-3134 25 mg + Scopolamine 0.5 mg|DRUG: D: Donepezil 10 mg + Scopolamine 0.5 mg|DRUG: E: Combo: Donepezil 10 mg + MK-3134 25 mg + Scopolamine 0.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Reduction Through Empowered Recovery (PRIME) Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain, Chronic|Depressive Symptoms|Depression|Disability Physical
Interventions: BEHAVIORAL: PRIME Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimization of Seasonal Malaria Chemoprevention (SMC) Delivery
Status: UNKNOWN
Conditions: Malaria|Anemia
Interventions: OTHER: FPD+NDOT|OTHER: FPD+DOT|OTHER: DDD+NDOT|OTHER: DDD+DOT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Dasatinib to Treat Philadelphia Positive Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Leukemia, Lymphoblastic, Acute, Philadelphia-Positive
Interventions: DRUG: dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Oxymorphone Extended-Release (Opana ER) Versus Oxycodone Controlled-Release (Oxycontin)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxymorphone ER|DRUG: Oxycodone CR|DRUG: Placebo|DRUG: Hydromorphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: ASC Therapy for Patients With Severe Respiratory COVID-19
Status: WITHDRAWN
Conditions: Respiratory Tract Diseases
Interventions: DRUG: Stem Cell Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CSD170303: Study to Assess Nicotine Uptake in Smokers From Electronic Cigarettes
Status: COMPLETED
Conditions: Smoking
Interventions: OTHER: FT21092|OTHER: FT21093|OTHER: FT21096|OTHER: FT21097
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Patterned Multichannel Vibrotactile Stimulation for the Longitudinal Treatment of Moderate Stage Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson's Disease
Interventions: DEVICE: Active Vibrotactile Coordinated Reset|DEVICE: Sham vibrotactile coordinated reset
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Occipital Nerve Stimulation in Trigeminal Autonomic Cephalgias
Status: RECRUITING
Conditions: Trigeminal Autonomic Cephalgia
Interventions: PROCEDURE: Occipital nerve stimulator implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Simplifying the Shang Ring Technique for Circumcision of Men and Boys
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: DEVICE: Shang Ring|DRUG: injectable anesthesia (lidocaine 1%)|DRUG: topical anesthesia (lidocaine 2.5%, prilocaine 2.5% cream)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: NeuroCognitive Communicator: Safety Study
Status: UNKNOWN
Conditions: Motor Neuron Disease, Amyotrophic Lateral Sclerosis|Tetraplegia
Interventions: DEVICE: NeuroCognitive Communicator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Pegylated Interferon Alone or in Combination With Ezetimibe for Patients With Chronic Hepatitis D
Status: UNKNOWN
Conditions: Hepatitis D, Chronic
Interventions: DRUG: Pegylated interferon alfa|DRUG: Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of an Etoricoxib and Tizanidine Fixed Dose Combination in Participants With Moderate to Severe Acute Low Back Pain (MK-0663B-164)
Status: WITHDRAWN
Conditions: Low Back Pain
Interventions: DRUG: MK-0663B|DRUG: DOLOCAM PLUS®|DRUG: Acetaminophen 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ivosidenib (AG-120) With Nivolumab in IDH1 Mutant Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumor|IDH1 Mutation|Glioma
Interventions: DRUG: ivosidenib and nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PXL-Platinum 330 in Eyes With Corneal Thinning Conditions
Status: WITHDRAWN
Conditions: Corneal Thinning|Keratoconus
Interventions: COMBINATION_PRODUCT: Pulsed or continuous lighting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SeniorWorkingLife (Danish Title: SeniorArbejdsLiv)
Status: ACTIVE_NOT_RECRUITING
Conditions: Work Related Upper Limb Disorder|Musculoskeletal Pain|Work Accident|Work Injury|Work-Related Stress Disorder|Occupational Exposure|Occupation-related Stress Disorder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetic Profile of Inhaled Liposomal Amphotericin B in Lung Transplant Recipients - Ambisome Study
Status: COMPLETED
Conditions: Lung Transplantation|Fungal Infections
Interventions: DRUG: Amphotericin B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Awareness Enhancing Interventions
Status: ACTIVE_NOT_RECRUITING
Conditions: Research Awareness
Interventions: OTHER: Navigation - Study Specific - Researcher Voice|OTHER: Navigation - Study Specific - Cancer Survivor Voice|OTHER: Navigation - Research General - Researcher Voice|OTHER: Navigation - Research General - Cancer Survivor Voice|OTHER: Brochure - Study Specific - Researcher Voice|OTHER: Brochure - Study Specific - Cancer Survivor Voice|OTHER: Brochure - Research General - Researcher Voice|OTHER: Brochure - Research General - Cancer Survivor Voice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Two Aspheric Intraocular Lenses for Micro-monovision
Status: NOT_YET_RECRUITING
Conditions: Cataract|Presbyopia|Pseudophakia
Interventions: DEVICE: Cataract surgery with insertion of Eyhance ICB00|DEVICE: Cataract surgery with insertion of Alcon SN60WF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics and Safety of INCB054707 in Participants With Normal Hepatic Function and Participants With Hepatic Impairment
Status: COMPLETED
Conditions: Renal Insufficiency|Kidney Diseases
Interventions: DRUG: INCB054707
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abnormal Food Timing and Circadian Dyssynchrony in Alcohol Induced Colon Carcinogenesis
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer
Interventions: OTHER: Right time eating|OTHER: Delayed time eating|PROCEDURE: Sigmoidoscopy|PROCEDURE: Optional 24h circadian assessment in the Biological Rhythms lab|OTHER: Alcohol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Renal Artery Stenting in Patients With Documented Resistant Hypertension and Atherosclerotic Renal Artery Stenosis (ANDORRA)
Status: TERMINATED
Conditions: Hypertension|Hypertension Resistant to Conventional Therapy|Angiographically Proven Grade III Unilateral or Bilateral Atherosclerotic Renal Artery Stenosis (ARAS) Greater Than or Equal to 60 Percent
Interventions: DEVICE: Renal artery Angioplasty plus stenting.|DRUG: Anti hypertensive, statin and antiplatelet medication.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Carboplatin and Gemcitabine Versus Gemcitabine Alone in Patients With Non-Small-Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Gemcitabine|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Hypoparathyroidism With Subcutaneous PTH (1-84) Injections: Effects on Muscle Function and Quality of Life
Status: COMPLETED
Conditions: Hypoparathyroidism
Interventions: DRUG: a: PTH (1-84)|DRUG: b:placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Neo-adjuvant Temozolomide Prior to Combined Temozolomide and Concurrent Accelerated Hypofractionated External Beam Radiotherapy Followed by Adjuvant Temozolomide in Patients With Newly Diagnosed Glioblastoma Multiforme
Status: COMPLETED
Conditions: Glioblastoma Mutliforme
Interventions: RADIATION: IMRT Technique|RADIATION: IMRT and accelerated hypofractionation technique|RADIATION: neo-adjuvant TMZ followed by accelerated hypofractionated EBRT|DRUG: Temozolomide and Accelerated Hypofractionation RT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of URC102 to Assess the Efficacy and Safety in Gout Patients
Status: COMPLETED
Conditions: Gout|Hyperuricemia
Interventions: DRUG: URC102 0.25mg|DRUG: URC102 0.5mg|DRUG: URC102 1.0mg|DRUG: URC102 2.0mg|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimized C-arm Cone Beam CT for the Endovascular Treatment (EVT) of Acute Stroke
Status: COMPLETED
Conditions: Stroke, Acute
Interventions: OTHER: Diagnostic Test: optimized C-Arm Cone Beam Computed Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: COLchicine and Non-enteric Coated Aspirin in the Cardiovascular Outcomes Trial of Patients With Type 2 Diabetes
Status: RECRUITING
Conditions: Diabete Type 2|Cardiovascular Diseases
Interventions: DRUG: Aspirin|DRUG: Aspirin Placebo|DRUG: Colchicine|DRUG: Colchicine Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Efficacy of TNFa Kinoid in Crohn's Disease Patients
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: TNF Kinoid|BIOLOGICAL: WFI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Taurolidine in Haemodialysis Catheter Related Bacteraemia
Status: COMPLETED
Conditions: Renal Dialysis|Catheter-Related Infections
Interventions: DEVICE: Taurolidine with heparin (500 units/ ml)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Return of First-phase Insulin Secretion in Type 2 Diabetes is Associated With Depletion of Pancreas Lipid
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: Low Glycemic Diet|OTHER: Control Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Korean CRC Screening Study PT13599
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BEHAVIORAL: interactive group education, navigation services and engagement of health care providers for referrals, and linkage to care.|BEHAVIORAL: Education Session on General Health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: Check List to Improve Patient Self-care and Product Defect Report in Continuous Ambulatory Peritoneal Dialysis
Status: ACTIVE_NOT_RECRUITING
Conditions: End-Stage Kidney Disease|Peritonitis
Interventions: OTHER: PD Product Check List
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Continued Efficacy and Safety of Zoledronic Acid (q 4 Wks vs. q 12 Wks) in the 2nd Year of Treatment in Patients With Bone Metastases From Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Zoledronic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and Subjective Effects of Heated Tobacco Products
Status: RECRUITING
Conditions: Tobacco Use
Interventions: OTHER: Test Product A|OTHER: Test Product B|OTHER: Test Product C|OTHER: Test Product D|OTHER: Reference Product E|OTHER: Reference Product F
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Reducing Blood Loss During Cesarean Hysterectomy for Placenta Accreta Spectrum
Status: COMPLETED
Conditions: Cesarean Section Complications
Interventions: DRUG: intravenous tranexamic acid|DRUG: Topical tranexamic acid|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Effectiveness of Bone-anchored Hearing Aids (Baha)
Status: WITHDRAWN
Conditions: Conductive Hearing Loss|Mixed Hearing Loss|Unilateral Deafness
Interventions: OTHER: audiological test battery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First Line Study of Irinotecan, Capecitabine and Oxaliplatin in Metastatic Gastric or Gastroesophageal Cancer.
Status: COMPLETED
Conditions: Gastrointestinal Neoplasm|Gastric Adenocarcinoma
Interventions: DRUG: Irinotecan-Capecitabine-Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Nivolumab+Ipilimumab Followed by Adjuvant Nivolumab or Neoadjuvant Nivolumab+Ipilimumab Followed by Adjuvant Observation Compared With Adjuvant Nivolumab in Treatment-Naive High-risk Melanoma Participants
Status: WITHDRAWN
Conditions: Melanoma
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Tolerability of Ectoin® Mouth and Throat Spray Althaea Honey (ERS09)
Status: COMPLETED
Conditions: Sore Throat|Acute Pharyngitis|Cough
Interventions: DEVICE: Ectoin® Mouth and Throat Spray Althaea Honey (ERS09)|DEVICE: EMSER® Hals-und Rachenspray (throat spray)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Acellular Epithelial Skin Substitute in Deep Partial-thickness Burns
Status: COMPLETED
Conditions: Wound Healing|Scar Formation
Interventions: DEVICE: Wound coverage by acellular skin substitute|DEVICE: Autologous skin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strength and Function Following Total Hip Arthroplasty
Status: COMPLETED
Conditions: Total Hip Arthroplasty
Interventions: BEHAVIORAL: Multi-Component Rehabilitation (CMC)|BEHAVIORAL: Control (CON)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Synbiotic Supplement on a High-protein Diet
Status: UNKNOWN
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Bifidobacterium spp plus bimuno- galacto-oligosaccharides|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A 2 Week, Crossover Trial of Dietary Nitrate in HTN
Status: COMPLETED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: Dietary nitrate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Carbohydrates in Irritable Bowel Syndrome
Status: RECRUITING
Conditions: Irritable Bowel Syndrome With Diarrhea
Interventions: DIETARY_SUPPLEMENT: Fructan reintroduction|DIETARY_SUPPLEMENT: Placebo reintroduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Talabostat in Treating Patients With Metastatic Kidney Cancer
Status: WITHDRAWN
Conditions: Kidney Cancer
Interventions: DRUG: talabostat mesylate|BIOLOGICAL: enzyme inhibitor therapy|DIAGNOSTIC_TEST: flow cytometry|DIAGNOSTIC_TEST: laboratory biomarker analysis|BIOLOGICAL: non-specific immune-modulator therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breast Cancer and Intrauterine Contraception
Status: UNKNOWN
Conditions: Breast Cancer|Contraception
Interventions: DEVICE: Silver and copper IUD (TCu380Ag)|DEVICE: Copper IUD (TCu380A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Titanium-Prepared Platelet Rich Fibrin in the Sinus Lifting Procedure
Status: COMPLETED
Conditions: Maxillary Sinus
Interventions: OTHER: Titanium-Prepared Platelet Rich Fibrin|OTHER: Allograft (CTBA Allograft)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Doxorubicin Compared With Observation or Cyclophosphamide and Methotrexate in Treating Older Women Who Have Undergone Surgery for Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: methotrexate|DRUG: pegylated liposomal doxorubicin hydrochloride|PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindfulness Group-based Intervention for Early Psychosis: A Pilot Study
Status: COMPLETED
Conditions: Psychotic Disorders|Schizophrenia
Interventions: BEHAVIORAL: Mindfulness Ambassador Council for Early Psychosis (MAC-EP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn If the Study Medicine Called Vepdegestrant Changes How the Body Processes the Other Study Medicine Called Midazolam
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Midazolam|DRUG: Vepdegestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Levamisole Combined With Standard Prednisolone in Warm Antibody Autoimmune Hemolytic Anemia.
Status: UNKNOWN
Conditions: Anemia|Anemia, Hemolytic|Anemia, Hemolytic, Autoimmune|Hemolysis|Hematologic Diseases|Autoimmune Diseases|Immune System Diseases|Pathologic Processes
Interventions: DRUG: levamisole|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) With Concurrent Chemotherapy and Bevacizumab As First-Line Therapy for Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Vismodegib 150 mg|DRUG: Placebo to vismodegib|DRUG: Bevacizumab|DRUG: Modified FOLFOX|DRUG: FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of 0.05 % Cyclosporine Ophthalmic Emulsion Compare With Tear in Meibomian Gland Dysfunction
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction
Interventions: DRUG: 0.05% cyclosporin eye drop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Silicone Oil Tamponade for Surgical Attenuation of Radiation Damage in Choroidal Melanoma
Status: COMPLETED
Conditions: Choroidal Melanoma
Interventions: OTHER: 1000CsK Silicon Oil Tamponade
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Kidney Spare the Nephron (STN) Study - A Study of CellCept (Mycophenolate Mofetil) and Rapamune (Sirolimus) in Kidney Transplant Recipients
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: mycophenolate mofetil [CellCept]|DRUG: Corticosteroids|DRUG: Calcineurin inhibitors|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab and External Beam Radiation Therapy in Treating Women With Stage III or Stage IV Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: RADIATION: external beam radiation therapy|DRUG: Herceptin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oculomotor Assessment of Traumatic Brain Injury (TBI)
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: DEVICE: Neuro Kinetics IPAS|DEVICE: Oculogica EyeBox|DEVICE: SyncThink EyeSync Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of the Height of the Operating Table During Spinal Anesthesia
Status: UNKNOWN
Conditions: Anesthesia, Spinal [E03.155.086.331]|Operating Tables [E07.325.662]
Interventions: PROCEDURE: Umbilicus|PROCEDURE: Lowest rib margin|PROCEDURE: Xiphoid|PROCEDURE: Nipple|DRUG: Umbilicus Bupivacaine|DRUG: Lowest rib margin Bupivacaine|DRUG: Xiphoid Bupivacaine|DRUG: Nipple Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Patch Test Skin Irritation/Sensitization of Cetaphil Restoraderm Skin Restoring Body Wash
Status: COMPLETED
Conditions: Skin Irritation
Interventions: OTHER: Cetaphil Restoraderm Skin Restoring Body Wash
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Automated Closed-Loop Ventilation Versus Conventional Ventilation on Duration and Quality of Ventilation
Status: RECRUITING
Conditions: Ventilator-free Days|Quality of Breathing
Interventions: PROCEDURE: INTELLiVENT-ASV|PROCEDURE: CONVENTIONAL VENTILATION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT