pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: SCH 727965 in Patients With Acute Myelogenous Leukemia and Acute Lymphoblastic Leukemia (P04717AM2)(TERMINATED)
Status: TERMINATED
Conditions: Leukemia, Myeloid, Acute|Lymphoblastic Leukemia, Acute
Interventions: DRUG: SCH 727965|DRUG: Gemtuzumab ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sintilimab Injection Combined With Concurrent CCRT in Locally Advanced Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Locally Advanced Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Sintilimab|DRUG: Chemotherapy|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Efficacy, Safety and Pharmacokinetic Study of XP21279 and Sinemet® in Parkinson's Disease Subjects
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: XP21279 and carbidopa (experimental)|DRUG: Sinemet (comparator)|DRUG: Placebo for XP21279 and carbidopa|DRUG: Placebo for Sinemet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mocetinostat With Vinorelbine in Children, Adolescents & Young Adults With Refractory and/or Recurrent Rhabdomyosarcoma
Status: RECRUITING
Conditions: Rhabdomyosarcoma
Interventions: DRUG: Vinorelbine|DRUG: Mocetinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Compare Topical Voriconazole to Placebo as a Pain Reducing Agent
Status: WITHDRAWN
Conditions: Pain|Thermal Injury|Burns|Hyperalgesia
Interventions: DRUG: Voriconazole (topical)|DRUG: Topical Sterile Water Placebo Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mechanisms Defending Fat Mass in Humans After Lipectomy
Status: COMPLETED
Conditions: Disproportionate Shape|Expanded Fat Pads
Interventions: PROCEDURE: Standard of Care with Liposuction|OTHER: Standard of Care without Liposuction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acetic Acid for the Detection of Esophageal Neoplasms
Status: UNKNOWN
Conditions: Barretts Esophagus With Low Grade Dysplasia|Dysplasia|Intestinal Metaplasia
Interventions: DIAGNOSTIC_TEST: Acetic acid chromoendoscopy|DIAGNOSTIC_TEST: Seattle protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Retrobulbar Injection of Anesthesia Versus Healon 5 in the Management of Intraoperative Floppy Iris Syndrome
Status: TERMINATED
Conditions: Intraoperative Floppy Iris Syndrome
Interventions: PROCEDURE: Healon 5 injection|PROCEDURE: Retrobulbar anesthetic injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study Comparing Mircera and Epoetin Alfa for the Treatment of Anemia in Dialysis Patients With Chronic Kidney Disease.
Status: TERMINATED
Conditions: Anemia
Interventions: DRUG: methoxy polyethylene glycol-epoetin beta|DRUG: Epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Bioavailability Study of Two Prototypes of Trazodone Controlled-release Products and Two Marketed Reference Products in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Trazodone HCl|DRUG: Trazodone HCl|DRUG: Trazodone HCl|DRUG: Trazodone HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Provocation of Freezing of Gait in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease|Freezing of Gait
Interventions: OTHER: walking speed|OTHER: visual loading|OTHER: dual task|OTHER: best side reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Open Label Controlled Trial of Eculizumab in Adult Patients With Plasma Therapy-sensitive Atypical Hemolytic Uremic Syndrome (aHUS)
Status: COMPLETED
Conditions: Atypical Hemolytic Uremic Syndrome
Interventions: DRUG: eculizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee
Status: RECRUITING
Conditions: Knee Injuries|Cartilage Injury|Cartilage Disease|Knee Discomfort
Interventions: PROCEDURE: Microfracture|DEVICE: Microfracture plus placement of Chondro-Gide® ACC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ADT +/- Darolutamide in de Novo Metastatic Prostate Cancer Patients With Vulnerable Functional Ability (PEACE6-Vulnerable)
Status: RECRUITING
Conditions: Prostate Cancer Metastatic
Interventions: DRUG: Darolutamide 300 mg|DRUG: Placebo|DRUG: Androgen deprivation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: At-home Auditory Training Clinical Trial
Status: COMPLETED
Conditions: Presbycusis|Aging|Hearing Loss
Interventions: BEHAVIORAL: Auditory training program|BEHAVIORAL: Sham Comparator: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Clinical Trial of Home-based Exercise Combined With a Slight Caloric Restriction on Obesity Prevention Among Women
Status: COMPLETED
Conditions: Obesity Prevention
Interventions: DIETARY_SUPPLEMENT: Low glycemic index diet|DIETARY_SUPPLEMENT: High glycemic index diet|OTHER: Home-based exercise intervention|OTHER: Non-exercisers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Toy-Type Nebulizer on Fear and Anxiety in Children Receiving Inhaler Treatment
Status: RECRUITING
Conditions: Children, Only|Fear Anxiety|Hospitalism in Children
Interventions: OTHER: inhaler treatment with the toy-type nebulizer and training on on the use of a nebulizer/mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Serum Phosphatemia Predictive Marker for AKI Diagnosis After Cardiac Surgery
Status: COMPLETED
Conditions: Cardiac Surgery With Cardiopulmonary Bypass|Complete Serum Phosphorus Measure|Complete Serum Creatinine Measure
Interventions: OTHER: cardiac surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial Comparing the Safety and Efficacy of Insulin Degludec and Insulin Glargine, Both With Insulin Aspart as Mealtime Insulin in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin degludec|DRUG: insulin glargine|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Irinotecan Liposome Injection (ONIVYDE®) in Patients With Small Cell Lung Cancer
Status: COMPLETED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Irinotecan liposome injection|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Acceptability of W-GenZD vs CBT-light Teletherapy for Adolescents Seeking Mental Health Services
Status: COMPLETED
Conditions: Depression|Anxiety
Interventions: DEVICE: W-GenZD Mobile Application|BEHAVIORAL: CBT-Light Teletherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment of a Closed-loop Insulin Delivery System
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: The Imperial College Closed-Loop Insulin Delivery System|DEVICE: Open loop
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supervised Exercise Therapy vs Home Exercises for Patients With Subacromial Impingement
Status: COMPLETED
Conditions: Shoulder Impingement Syndrome
Interventions: OTHER: supervised exercise|OTHER: homebased exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single-Arm Study To Evaluate The Efficacy and Safety of Valoctocogene Roxaparvovec in Hemophilia A Patients (BMN 270-301)
Status: ACTIVE_NOT_RECRUITING
Conditions: Hemophilia A
Interventions: BIOLOGICAL: valoctocogene roxaparvovec
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patupilone (EPO 906) in Patients With Recurrent or Progressive Glioblastoma
Status: COMPLETED
Conditions: Recurrent Glioblastoma Planned for Reoperation
Interventions: DRUG: Patupilone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Tumor Resection Guided by Intraoperative Indocyanine Green Dye Fluorescence Angiography in Patients With Sarcoma
Status: RECRUITING
Conditions: Bone Sarcoma|Soft Tissue Sarcoma
Interventions: OTHER: Non-Interventional Study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Tolerability of Once-daily Oral Aripiprazole in Children and Adolescents With Tourette's Disorder
Status: COMPLETED
Conditions: Tourette's Disorder|Tic Disorder
Interventions: DRUG: Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 2-Year Phase 3 Study Of CP-690,550 In Patients With Active Rheumatoid Arthritis On Background Methotrexate
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: CP-690,550|DRUG: CP-690,550|DRUG: CP-690,550|DRUG: CP-690,550|DRUG: Placebo|DRUG: CP-690,550|DRUG: Placebo|DRUG: CP-690,550
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ExAblate Blood Brain Barrier Disruption (BBBD) for Planned Surgery in Suspected Infiltrating Glioma
Status: SUSPENDED
Conditions: Glioma
Interventions: DEVICE: ExAblate 4000 - Type 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Tacrolimus Based Immunosuppressive Regimens in Recipients Receiving Marginal Donor Kidneys
Status: COMPLETED
Conditions: KIDNEY TRANSPLANTATION
Interventions: DRUG: tacrolimus|DRUG: mycophenolate mofetil|DRUG: steroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Envafolimab Immunotherapy After ctDNA EGFR Clearance by Treatment With Almonertinib in EGFR-Mutant, PD-LI Positive NSCLC
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Almonertinib Envafolimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Drug Interaction Between LC15-0444 and Pioglitazone After Oral Administration in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LC15-0444, Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial for Patients Not Qualifying for TT4 and TT5 Protocols Because of Prior Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Myeloma
Interventions: DRUG: Melphalan|DRUG: Velcade|DRUG: Thalidomide|DRUG: Dexamethasone|DRUG: Cisplatin|DRUG: Adriamycin|DRUG: Cyclophosphamide|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Basal Insulins for Patients With Type 2 Diabetes (IOOY)
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: Insulin Lispro Protamine Suspension|DRUG: Detemir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kinesiotaping Versus Pressure Garments on Secondary Upper Extremity Lymphedema.
Status: COMPLETED
Conditions: Lymphedema of Upper Arm|Burns Chest Right Lateral|Burns Chest Left Lateral
Interventions: DEVICE: Kinesiotape|DEVICE: Pressure garment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spartalizumab and Low-dose PAzopanib in Refractory or Relapsed Solid TumOrs of Pediatric and Adults
Status: RECRUITING
Conditions: Refractory or Recurrent Solid Tumor
Interventions: DRUG: Spartalizumab in Pediatric cohort|DRUG: Low-dose Pazopanib in Pediatric Cohort|DRUG: Spartalizumab in Adult cohort|DRUG: Low-dose Pazopanib in Adult Cohort
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Pharmacological Study With 2B3-101 in Patients With Breast Cancer and Leptomeningeal Metastases
Status: UNKNOWN
Conditions: Meningeal Carcinomatosis
Interventions: DRUG: 2B3-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interrogating Biological Signaling Pathway Dysregulations and In Vitro Screening With Personalized Therapies in Relapsed or Refractory Mantle Cell Lymphoma, MCL MATCH Trial
Status: RECRUITING
Conditions: Recurrent Mantle Cell Lymphoma|Refractory Mantle Cell Lymphoma
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Follow-Up
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Surgery for Masaoka-Koga I-II Thymoma
Status: COMPLETED
Conditions: Thymoma|Masaoka Stage I|Masaoka Stage II
Interventions: PROCEDURE: the subxiphoid approach thoracoscopic thymectomy|PROCEDURE: the lateral intercostal approach thoracoscopic thymectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diaphragmatic Activity During Weaning With NAVA, a Pilot Study (NAVA: Neurally Adjusted Ventilatory Assist)
Status: COMPLETED
Conditions: Postoperative Patients
Interventions: PROCEDURE: weaning protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Protease Inhibition for COVID-19 in Standard-Risk Patients (EPIC-SR).
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: PF-07321332|DRUG: Ritonavir|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of LXH254 in Patients With Advanced Solid Tumors Haboring MAPK Pathway Alterations
Status: TERMINATED
Conditions: NSCLC|Ovarian Cancer|Melanoma|Other Solid Tumors
Interventions: DRUG: LXH254|DRUG: PDR001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antibacterial Tactics Based on Presepsin Level in Thoracic Aorta Surgery Patients
Status: RECRUITING
Conditions: Aortic Aneurysm and Dissection|Cardiac Valve Disease|Thoracic Aortic Aneurysm|Thoracic Aortic Dissection
Interventions: DRUG: Ampicillin-sulbactam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Odanacatib (MK-0822) in Participants With Involutional Osteoporosis (MK-0822-022)
Status: COMPLETED
Conditions: Osteoporosis Postmenopausal
Interventions: DRUG: Odanacatib|DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Calcium carbonate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intravenous Acetadote on Incidence of Contrast Induced Nephropathy
Status: UNKNOWN
Conditions: Nephropathy
Interventions: DRUG: intravenous NAC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Inside Study II: Oligosaccharides Versus Placebo and Hard Stools
Status: UNKNOWN
Conditions: Healthy With Hard and/or Lumpy Stools
Interventions: OTHER: oligosaccharides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human Telomerase Reverse Transcriptase Messenger RNA (hTERT mRNA) Transfected Dendritic Cell Vaccines
Status: WITHDRAWN
Conditions: Metastatic Prostate Cancer
Interventions: BIOLOGICAL: hTERT mRNA DC|BIOLOGICAL: hTERT mRNA DC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effects of Inarigivir on Immune Response and Viral Markers in Chronic Hepatitis B Patients
Status: TERMINATED
Conditions: HBV|Hepatitis B|Hepatitis B, Chronic
Interventions: DRUG: inarigivir soproxil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Respiratory Function, Exercise Capacity and Peripheral Muscle Strength Among Patients With CF, PCD and Healthy Children
Status: COMPLETED
Conditions: Primary Ciliary Dyskinesia|Cystic Fibrosis
Interventions: OTHER: Measurement of functional capacity|OTHER: pulmonary function test|OTHER: Functional capacity|OTHER: Peripheral muscle strength|OTHER: Respiratory muscle strength
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pivotal Assessment of the Effects of Bioactive on Health and Wellbeing. From Human Genome to Food Industry
Status: TERMINATED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Dairy BEF|DIETARY_SUPPLEMENT: Egg BEF|DIETARY_SUPPLEMENT: Bakery BEF|DIETARY_SUPPLEMENT: Bakery placebo|DIETARY_SUPPLEMENT: Dairy placebo|DIETARY_SUPPLEMENT: Egg placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of OBX-115 in Advanced Solid Tumors
Status: RECRUITING
Conditions: Tumor Skin|Metastatic Melanoma|Melanoma|Lung Cancer|Metastatic Lung Cancer|Non Small Cell Lung Cancer|Metastatic Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: OBX-115
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility, Safety, and Potential Efficacy of Fecal Microbiota Transplantation (FMT) for Gastrointestinal Dysfunction in Children Following Hematopoietic Cell Transplant (HCT).
Status: NOT_YET_RECRUITING
Conditions: Gastro-Intestinal Disorder
Interventions: DRUG: Fecal microbiota transplant (FMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The North Kynouria Project
Status: RECRUITING
Conditions: Cardiovascular Diseases|Heart Diseases|Cerebrovascular Disease|Coronary Disease|Dyslipidemias|Stroke (CVA) or TIA|Myocardial Infarction|Hypertension|Diabetes Mellitus|Peripheral Artery Disease
Interventions: BEHAVIORAL: Patient counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Genicular Nerve Block in Rheuamtoid Arthritis
Status: COMPLETED
Conditions: Pain|Joint Function Disorder|Inflammation
Interventions: DRUG: Bupivacaine hydrochloride 0.5% (Marcaine, Pfizer)|DRUG: triamcinolone 40 milligrams (Kenacort, Bristol Myers Squip)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Triprizumab and Radiotherapy in Operable Patients With Stage IIA-IIIA Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer|Neoadjuvant Therapy|Radiotherapy|Immunotherapy
Interventions: DRUG: Toripalimab|RADIATION: Conventional segmental radiotherapy|OTHER: opreation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postprandial Differences After Herring and Beef
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: OTHER: Baked beef|OTHER: Baked herring|OTHER: Pickled herring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bronchodilatation Effects of a Small Volume Spacer Used With a Metered-Dose Inhaler
Status: COMPLETED
Conditions: Asthma
Interventions: DEVICE: Small volume spacer and/or Rinsing the mouth with water
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Progenitor Cell Therapy in Dilative Cardiomyopathy
Status: COMPLETED
Conditions: Heart Failure, Congestive|Cardiomyopathy, Dilated|Stem Cell Transplantation
Interventions: PROCEDURE: intracoronary infusion of BMC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Single Dose of Betamethasone in Children With Symptomatic Adenovirus Infection
Status: RECRUITING
Conditions: Adenovirus
Interventions: DRUG: Bentelan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Muscle-invasive Bladder Cancer
Status: RECRUITING
Conditions: Muscle Invasive Bladder Carcinoma|Localized Cancer|Urothelial Carcinoma
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Obesity-Related Glycine Deficiency: Investigating a Long-standing Metabolic Paradox Using Bedside and Bench Approaches
Status: COMPLETED
Conditions: Glycine Metabolism Disturbances|Insulin Resistance|Morbid Obesity|Oxidative Stress
Interventions: PROCEDURE: Bariatric surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigation of the Efficacy of CARDIO Softgels PLUS Best-standard-of-care in the Recovery of Patients With COVID-19
Status: COMPLETED
Conditions: COVID|Covid-19
Interventions: DIETARY_SUPPLEMENT: Best Standard of Care + CARDIO|DIETARY_SUPPLEMENT: Best Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Apical Repair Methods in Women Undergoing Repairs for Prolapse
Status: ACTIVE_NOT_RECRUITING
Conditions: Pelvic Organ Prolapse|Surgery|Quality of Life|Complication
Interventions: PROCEDURE: fixation of the vaginal apex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise Therapy in Combination With Central Nervous System-targeted Treatment for Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis|Osteo Arthritis Knee
Interventions: OTHER: NEMEX program combined with a CNS-focused protocol|OTHER: NEMEX program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Neuromuscular Blockade on the Composite Variability Index (CVI) During Laryngoscopy
Status: COMPLETED
Conditions: Anesthesia|Neuromuscular Blockade
Interventions: DRUG: Saline 0.06 ml/kg|DRUG: Rocuronium 0.2 mg/kg|DRUG: Rocuronium 0.4 mg/kg|DRUG: Rocuronium 0.6 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Open-label, Single-dose Study to Determine the Metabolism and Excretion of [14C]E2006 in Healthy Male Subjects
Status: COMPLETED
Conditions: Metabolism and Excretion
Interventions: DRUG: E2006
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Testosterone and rHGH in FSHD
Status: COMPLETED
Conditions: Facioscapulohumeral Muscular Dystrophy
Interventions: DRUG: Testosterone Enanthate|DRUG: Somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platin-based Chemotherapeutics to Enhance Dendritic Cell Vaccine Efficacy in Melanoma Patients
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: DC vaccination|BIOLOGICAL: DC vaccination with cisplatinum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tucatinib Plus Trastuzumab in Patients With HER2+ Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Adenocarcinoma
Interventions: DRUG: Trastuzumab|DRUG: Tucatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Civamide Nasal Solution for Postherpetic Neuralgia of the Trigeminal Nerve
Status: TERMINATED
Conditions: Postherpetic Neuralgia
Interventions: DRUG: Civamide Nasal Spray|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Isolation of Circulating Tumor Cells Using a Novel EMT-Based Capture Method
Status: COMPLETED
Conditions: Metastatic Progressive Castration-resistant Prostate Cancer|Metastatic Progressive Breast Cancer
Interventions: DEVICE: Mesenchymal-marker based ferrofluid (N-cadherin or O-cadherin based)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: FMT+SOX+Sintilimab as First-line Treatment for Advanced Gastric Cancer
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer
Interventions: COMBINATION_PRODUCT: Fecal Microbiota Transplantation (FMT)+chemotherapy+immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Developmental Intervention for Hospitalized Newborns With Congenital Heart Disease
Status: RECRUITING
Conditions: Cardiology|Infant Development|Development Delay
Interventions: BEHAVIORAL: NIDCAP Developmental Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Evaluate Safety and Immunogenicity of Different Priming and Booster Regimens With Adjuvanted H5N8 and/or H5N6 Influenza Vaccine in Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Influenza, Human|Infections|Respiratory Tract Infections|Virus Diseases|Infection Viral
Interventions: BIOLOGICAL: aH5N8c on Day 1|BIOLOGICAL: aH5N6c on Day 1|BIOLOGICAL: aH5N8c on Day 22|BIOLOGICAL: aH5N6c on Day 22|BIOLOGICAL: aH5N8c on Day 202
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Improving PTSD Treatments for Adults With Childhood Trauma
Status: COMPLETED
Conditions: Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: Trauma-focused treatment|BEHAVIORAL: Emotion regulation training|BEHAVIORAL: Intensive Trauma-focused treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-dose Chemotherapy+G-CSF in Peripheral Blood Stem Cell Mobilization in Patients With Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Etoposide|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Efficacy and Safety of Benzoyl Peroxide Used in Combination With Clindamycin vs. Benzoyl Peroxide Used in Combination With Clindamycin and Doxycycline in the Treatment of Moderate Acne
Status: COMPLETED
Conditions: Acne
Interventions: DRUG: Benzoyl peroxide with clindamycin|DRUG: Benzoyl peroxide with clindamycin and doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of VIM With VIT in Children With Relapsed and Refractory Soft Tissue Sarcoma.
Status: RECRUITING
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: Mitoxantrone Hydrochloride Liposome+Irinotecan+Vincristine|DRUG: Temozolomide+Irinotecan+Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Licefreee Spray Against Nix 1% Permethrin
Status: COMPLETED
Conditions: Pediculosis Capitis
Interventions: DRUG: Licefreee Spray|DRUG: 1% permethrin creme rinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clofarabine for Relapsed or Refractory T-Cell or B-Cell Non-Hodgkin Lymphoma (NHL)
Status: COMPLETED
Conditions: Lymphoma, B-Cell|Lymphoma, Non-Hodgkin
Interventions: DRUG: CLOFARABINE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone Vs Methylprednisolone for the Treatment of Patients With ARDS Caused by COVID-19
Status: UNKNOWN
Conditions: Covid19|ARDS
Interventions: DRUG: Dexamethasone|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Safety and Effectiveness of NovoThirteen® (rFXIII) During Treatment of Congenital FXIII Deficiency in Japan
Status: ENROLLING_BY_INVITATION
Conditions: Congenital Bleeding Disorder|Congenital FXIII Deficiency
Interventions: DRUG: recombinant factor XIII
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clozapine/Paliperidone Versus Clozapine/Placebo in Resistant Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizophrenic Disorders|Psychotic Disorder
Interventions: DRUG: paliperidone clozapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Efficacy and Safety of IncobotulinumtoxinA (Xeomin) in Parkinson's Tremor: A Customized Approach
Status: COMPLETED
Conditions: Parkinson|Tremor
Interventions: DRUG: incobotulinumtoxinA|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Beta-glucan Effects on Lipid Profile, Glycemia and inTestinal Health (BELT)
Status: UNKNOWN
Conditions: Atherosclerosis
Interventions: DIETARY_SUPPLEMENT: Beta-glucans|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Training Study to Characterize Biomarkers to Chickenpox and Yellow Fever Vaccines
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Varicella-zoster virus|BIOLOGICAL: Yellow Fever Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Almonertinib Therapy in Patients With Abnormal Liver Function After EGFR-TKI Treatment, or Almonertinib First-line Therapy in Patients With Basic Hepatopathy
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Almonertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combining a Mediterranean Diet With Physical Activity to Address Cardiometabolic Risk
Status: COMPLETED
Conditions: Cardiometabolic Risk
Interventions: BEHAVIORAL: Mediterranean diet (MedDiet)|BEHAVIORAL: Physical activity (PA)|BEHAVIORAL: Mediterranean diet and physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment for Blood Clots in the Veins of the Legs
Status: COMPLETED
Conditions: Embolism|Thrombophlebitis
Interventions: DRUG: Recombinant Tissue Plasminogen Activator|DRUG: Heparin|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: An Open-label, Dose Escalation Trial to Evaluate the Safety and Pharmacokinetics of HMPL-523 in Patients With Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Hodgkin Lymphoma
Interventions: DRUG: HMPL-523
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence of FODMAP Intolerance and JHS in FGID and Association With Microbiome, Dyssynergic Defecation and Dietary Intervention
Status: UNKNOWN
Conditions: Functional Gastrointestinal Disorders
Interventions: OTHER: FODMAP diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Clinical Efficacy and Safety Study of Delayed Release 6MP in Crohn's Disease
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: DRUG: Delayed Release 6 mercaptopurine|DRUG: 6 Mercaptopurine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Recovery After Surgery (ERAS) Versus Conventional Protocol After Laparoscopic Gastrectomy
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: PROCEDURE: ERAS perioperative cares|PROCEDURE: Conventional perioperative cares
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CIC Behavioral Economics in Children With Spina Bifida
Status: COMPLETED
Conditions: Spina Bifida|Neurogenic Bladder
Interventions: BEHAVIORAL: Present Bias without Loss Aversion|BEHAVIORAL: Present Bias with Loss Aversion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Understanding the Person, Exploring Change Across Psychotherapies
Status: UNKNOWN
Conditions: Depression|Anxiety Disorders
Interventions: BEHAVIORAL: Individual Psychotherapy|BEHAVIORAL: Internet-delivered Cognitive Behavioural Therapy (iCBT)|BEHAVIORAL: Group Cognitive Behavioural Therapy (group CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: R-2487 in Patients With Sjogren's Syndrome (SS)
Status: NOT_YET_RECRUITING
Conditions: Sjogren's Syndrome|Sjögren|Sjögren Syndrome, Unspecified
Interventions: DRUG: R-2487
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transdiagnostic Group Treatments for Patients With Common Mental Disorders in Primary Health Care
Status: COMPLETED
Conditions: Anxiety Disorders|Depressive Disorders|Stress Disorders
Interventions: BEHAVIORAL: CBT|BEHAVIORAL: MMI|BEHAVIORAL: CAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intradermal Needle Therapy for Major Depressive Disorder
Status: NOT_YET_RECRUITING
Conditions: Major Depressive Disorder
Interventions: DRUG: SSRIs|PROCEDURE: acupuncture|PROCEDURE: sham acupuncture|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maternal Vitamin D for Infant Growth (MDIG) Trial
Status: COMPLETED
Conditions: Pregnancy
Interventions: DIETARY_SUPPLEMENT: Vitamin D3 (cholecalciferol)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: VERifynow in DIabetes Non-responsiveness: a Study on Switching From Clopidogrel to Prasugrel
Status: COMPLETED
Conditions: Diabetes Mellitus Type II|Acute Coronary Syndrome
Interventions: DRUG: Prasugrel.|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Radiographic Assessment of Partial and Complete Pulpotomy in Primary Molars Using MTA
Status: UNKNOWN
Conditions: Pulp Disease, Dental
Interventions: COMBINATION_PRODUCT: MTA material
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Valproic Acid on Extinction-based Therapy in Patients With Fear of Spiders.
Status: COMPLETED
Conditions: Phobia, Specific
Interventions: DRUG: Valproic Acid|DRUG: Placebo|BEHAVIORAL: Fear reactivation|BEHAVIORAL: No fear reactivation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of STA-5312 in Subjects With Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Advanced or Metastatic Solid Tumors
Interventions: DRUG: STA-5312
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of High-Frequency Jet Ventilation During Percutaneous Tracheostomy
Status: COMPLETED
Conditions: Tracheostomy Complication|High-frequency Jet Ventilation|Percutaneous Tracheostomy
Interventions: DEVICE: Percutaneous tracheostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study for Safety and Efficacy Evaluation of Imatinib Mesylate in Children With Acute Lymphoblastic Leukemia (ALL) Philadelphia Chromosome-positive (Ph+)
Status: SUSPENDED
Conditions: Acute Lymphoblastic Leukemia (ALL) Philadelphia Chromosome-positive (Ph+)
Interventions: DRUG: Imatinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketamine Tolerated Dose for Postpartum Depression and Pain After Cesarean Delivery (PREPARE 1)
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain, Postoperative|Depression, Postpartum
Interventions: DRUG: Ketamine (Ketalar) Dose Level 1|DRUG: Ketamine (Ketalar) Dose Level 2|DRUG: Ketamine (Ketalar) Dose Level 3|DRUG: Ketamine (Ketalar) Dose Level 4
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Feasibility, Acceptability and Preliminary Effects of the Spiritual Care Assessment and Intervention
Status: COMPLETED
Conditions: Advanced Cancer|Metastatic Cancer
Interventions: BEHAVIORAL: SCAI (Spiritual Care Assessment and Intervention)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomized Controlled Trial Comparing Intrathecal Morphine With Quadratus Lumborum Block for Post-cesarean Delivery Analgesia
Status: UNKNOWN
Conditions: Cesarean Section
Interventions: OTHER: Bilateral Quadratus lumborum block with 0.5% ropivacaine|OTHER: Intrathecal Morphine with 100 mcg morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Repetitive Trans-spinal Magnetic Stimulation on Axial Motor Symptoms in PD
Status: COMPLETED
Conditions: Adverse Effect of Drug Therapy Levodopa
Interventions: DEVICE: non invasive repetitive magnetic stimulation (real Transcranial + real trans-spinal )|DEVICE: non invasive repetitive magnetic stimulation (real Transcranial + sham trans-spinal )sham trans-spinal magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab, INCB081776, and Radiation Therapy for Head and Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: INCB081776|DRUG: Pembrolizumab|RADIATION: Palliative RT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Preemptive APRV on Patients With High Risk for ARDS
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome|Intensive Care Unit
Interventions: DEVICE: Mechanical Ventilation Mode (airway pressure release ventilation )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ACE Inhibitors Combined With Exercise for Seniors - Pilot Study
Status: COMPLETED
Conditions: Hypertension|Aging
Interventions: BEHAVIORAL: Exercise|DRUG: ACE inhibitor + exercise|DRUG: Thiazide diuretic + exercise|DRUG: Angiotensin receptor blocker + exercise
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Growth and Tolerance Trial on Infant Formula With HMO
Status: TERMINATED
Conditions: Healthy Growth
Interventions: OTHER: Standard infant formula|OTHER: Infant formula supplemented with HMO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Relationship Between Risperdal Treatment and Quality of Life in Patients With Alzheimer's Disease and Behavioural and Psychological Symptoms of Dementia (BPSD)
Status: UNKNOWN
Conditions: Dementia|Alzheimer's Disease
Interventions: DRUG: Risperdal,reminyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose:
Clinical trial: Safety and Effectiveness of NicVAX in Treating Nicotine Dependent Individuals
Status: COMPLETED
Conditions: Smoking Cessation|Tobacco Use Cessation
Interventions: BIOLOGICAL: NicVAX|BIOLOGICAL: NicVAX|BIOLOGICAL: NicVAX|BIOLOGICAL: NicVAX|BIOLOGICAL: NicVAX
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Levosimendan in Severe Acute Heart Failure in Critical Children
Status: TERMINATED
Conditions: Acute Heart Failure
Interventions: DRUG: Levosimendan|DRUG: Conventional intensified inotropic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preliminary Safety and Tolerability of CD19x22 CAR T Cells in Adolescent and Adult R/R B-NHL Patients
Status: RECRUITING
Conditions: Non-Hodgkin Lymphoma
Interventions: DRUG: CD19x22 CAR T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery
Status: COMPLETED
Conditions: Heart Disease
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lymphoma RadVax LYMPHOMA: A PHASE II TRIAL OF NIVOLUMAB + LOW DOSE RADIOTHERAPY FOR INCOMPLETE RESPONDERS
Status: TERMINATED
Conditions: Hodgkin Lymphoma
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GALLANT: Metronomic Gemcitabine, Doxorubicin, Docetaxel and Nivolumab for Advanced Sarcoma
Status: RECRUITING
Conditions: Sarcoma
Interventions: DRUG: Gemcitabine|DRUG: Doxorubicin|DRUG: Docetaxel|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT