pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Virtual Reality Glasses Integrated With Sign Language on Dental Anxiety Among Children With Hearing Impairment During Pulpotomy Procedure
Status: RECRUITING
Conditions: Dental Anxiety
Interventions: OTHER: virtual reality glasses|OTHER: Tell Show and Do
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Treatment With Lenalidomide-Melphalan-Dexamethasone in Patients With Primary (AL) Amyloidosis
Status: COMPLETED
Conditions: Primary Amyloidosis
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between TPRK Versus AAPRK in Correction of Myopia
Status: COMPLETED
Conditions: Refractive Surgery|Myopia
Interventions: PROCEDURE: Transepithelial photorefractive keratectomy|PROCEDURE: Alcohol assisted photorefractive keratectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EFFECTS OF MOXIFLOXACIN AND GEMIFLOXACIN ON BLOOD GLUCOSE AND ECG MORPHOLOGY OF EUGLYCEMICS:A CLINICAL STUDY
Status: COMPLETED
Conditions: Blood Glucose, Low|Hypoglycemia
Interventions: DRUG: Moxifloxacin 400mg|DRUG: Gemifloxacin 320 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Phase I/II Study of Nivolumab and Ipilimumab Combined With Nintedanib in Non Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer|Lung Cancer, Nonsmall Cell|Non Small Cell Lung Cancer Metastatic
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab|DRUG: Nintedanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Transplantation With or Without Rituximab in Treating Patients With Relapsed or Progressive B-Cell Diffuse Large Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: rituximab|DRUG: carmustine|DRUG: cyclophosphamide|DRUG: etoposide|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effect of SGLT2 Inhibitors on Heart Rate Variability and BDNF Levels in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes|Heart Rate Variability
Interventions: DIAGNOSTIC_TEST: 24-hour rhythm Holter|DIAGNOSTIC_TEST: 36 item Short Form Survey (SF-36)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Global Study to Assess the Effects of MEDI4736 (Durvalumab) in Patients With Locally Advanced or Metastatic Non Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: MEDI4736
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Bile Acids on GLP-1 Secretion
Status: COMPLETED
Conditions: Type 2 Diabetes|Obesity
Interventions: DRUG: Colesevelam|DRUG: Chenodeoxycholic Acid|OTHER: saline|DRUG: Colesevelam 3750 mg + chenodeoxycholic acid 1250 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Accuracy and Reliability of Ultra Low Dose CBCT Versus CBCT Imaging in Semi-automated Segmentation of the Mandibular Condyle (A Diagnostic Accuracy Study)
Status: UNKNOWN
Conditions: CBCT - Condyle - Semi-automated Segmentation - Ultra-low Dose
Interventions: RADIATION: CBCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Ammonium Lactate Lotion 12% (Lac-hydrin®) and Halobetasol Propionate Ointment 0.05% (Ultravate®) in the Treatment and Maintenance of Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Lac-Hydrin lotion (ammonium lactate lotion 12%) ; UItravate ointment (halobetasol propionate ointment 0.05%)|DRUG: Lac-Hydrin lotion (ammonium lactate lotion 12%); placebo ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study for Kidney Transplant Recipients at High-Risk of Cytomegalovirus Infection
Status: COMPLETED
Conditions: Cytomegalovirus Disease
Interventions: DRUG: NPC-21 Low dose|DRUG: NPC-21 High dose|DRUG: NPC-21 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study the Role of Genetic Variation in the Determining Lipid Profile Response to Dietary Change
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: OTHER: Dietary experiments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Tolerability of Beclomethasone Plus Salbutamol in HFA pMDI Fixed Combination vs Beclomethasone Plus Salbutamol in CFC pMDI Fixed Combination in a 12-week Treatment Period of Adult Patients With Uncontrolled Asthma
Status: COMPLETED
Conditions: Bronchial Asthma
Interventions: DRUG: salbutamol 100 mcg|DRUG: BDP/salbutamol HFA pMDI|DRUG: BDP/salbutamol CFC pMDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study Between Amlodipine 10mg And 5mg With Hypertension For Whom 5mg Is Insufficient
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Amlodipine|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Bonviva (Ibandronate) Once Monthly in Post-Menopausal Women With Osteopenia
Status: COMPLETED
Conditions: Post-Menopausal Osteopenia
Interventions: DRUG: Placebo|DRUG: ibandronate [Bonviva/Boniva]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of BMS-823778 in Subjects With Hypercholesterolemia
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: BMS-823778|DRUG: BMS-823778|DRUG: BMS-823778|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intravaneous Iron(1000 mg Low Molecular Weight Iron Dextran Over 60 Minutes) for Pregnant Women
Status: COMPLETED
Conditions: Pregnancy
Interventions: DRUG: Intravaneous iron(low molecular weight iron dextran)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Neck Stabilization Exercise Plus Cardiopulmonary Rehabilitation on Pulmonary Function of SCI
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: OTHER: Cervical Cranioflexion exercise plus cardiopulmonary exercise|OTHER: Cervical stretch exercise plus cardiopulmonary rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Instrument-Assisted Soft Tissue Mobilization on Proprioception and Disability in Patients With Cervicogenic Headache
Status: UNKNOWN
Conditions: Cervicogenic Headache
Interventions: OTHER: instrumented assisted soft tissue mobilization|OTHER: traditional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: End-Tidal Carbon Dioxide Monitoring Device for Sedation During Endoscopic Ultrasonography
Status: UNKNOWN
Conditions: Endoscopic Ultrasonography|Sedation|Monitoring
Interventions: DEVICE: Novel end-tidal CO2 monitoring device|DEVICE: SpO2 and respiratory motion monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Reducing Readmissions in High-Risk Ostomates
Status: TERMINATED
Conditions: Ileostomy
Interventions: OTHER: Pre-operative education (standard of care)|OTHER: Home health care visits (standard of care)|OTHER: Follow-up post-operative visits|OTHER: Patient Data Collection Form|OTHER: Healthcare Utilization Form|OTHER: The City of Hope QOL Survey for Ostomy Patients|OTHER: Phone call with CWOCN or PA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Ezetimibe and Statins on Postprandial Lipemia in Type 2 Diabetes
Status: COMPLETED
Conditions: Postprandial Lipemia|Type 2 Diabetes
Interventions: DRUG: ezetimibe tablets|DRUG: simvastatin tablets|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous VEGF Trap in Treating Patients With Relapsed or Refractory Advanced Solid Tumors or Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Cancer
Interventions: BIOLOGICAL: ziv-aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Use of Er:YAG and Nd:YAG Laser
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: DEVICE: Periodontal curettes|DEVICE: Er-YAG+Nd-YAG lasers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of an Investigational Herpes Zoster Vaccine (Z-1018) Compared to Shingrix® in Healthy Adults
Status: RECRUITING
Conditions: Shingles|Herpes Zoster|Vaccine-Preventable Diseases
Interventions: BIOLOGICAL: Z-1018|BIOLOGICAL: Shingrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy Study on Dimethyl Fumarate to Treat Moderate to Severe Plaque Psoriasis
Status: WITHDRAWN
Conditions: Plaque Psoriasis
Interventions: DRUG: FP187|DRUG: Dimethyl fumarate|DRUG: FP187 placebo|DRUG: Fumaderm® placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of the VAC∆6 Vaccine in Volunteers Aged 18-40 Years
Status: COMPLETED
Conditions: Smallpox|Monkeypox|Cowpox|Vaccinia Virus Infection
Interventions: BIOLOGICAL: VAC∆6 vaccine - оnce at a dose of 10⁶ PFU|BIOLOGICAL: VAC∆6 vaccine - once at a dose of 10⁷ PFU|BIOLOGICAL: VAC∆6 vaccine - twice at a dose of 10⁶ PFU|BIOLOGICAL: Live smallpox vaccine (Smallpox vaccine) + The OspaVir® inactivated smallpox vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: GTX-RT in Borderline Resectable Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: Capecitabine|DRUG: Gemcitabine|DRUG: Docetaxel|RADIATION: Stereotactic body radiation therapy (SBRT)|OTHER: Restaging review after radiation|PROCEDURE: Surgery|DRUG: 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of AK112 (PD1/VEGF Bispecific) in Combination With Chemotherapy in Patients With NSCLC
Status: RECRUITING
Conditions: NSCLC
Interventions: DRUG: AK112|DRUG: Pemetrexed|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindfulness-Based Intervention for Family Caregivers
Status: NOT_YET_RECRUITING
Conditions: Caregiving Stress
Interventions: BEHAVIORAL: Mindfulness and psychoeducation|BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Autologous Stem Cell Transplantation in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Acute Anterior Wall Myocardial Infarction
Interventions: GENETIC: Intracoronary aotologous stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: QBSAfe: A Novel Approach to Diabetes Management Focused on Quality of Life, Burden of Treatment, Social Integration and Avoidance of Future Events
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus
Interventions: OTHER: QBSAfe Toolkit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Capivasertib+Paclitaxel as First Line Treatment for Patients With Locally Advanced or Metastatic TNBC
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple Negative Breast Neoplasms
Interventions: DRUG: Capivasertib|DRUG: Paclitaxel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine if the Drug, Pyrvinium Pamoate, is Safe and Tolerable in Patients With Pancreatic Cancer
Status: RECRUITING
Conditions: Resectable Pancreatic Ductal Adenocarcinoma|Stage 0 Pancreatic Cancer AJCC v8|Stage I Pancreatic Cancer AJCC v8|Stage IA Pancreatic Cancer AJCC v8|Stage IB Pancreatic Cancer AJCC v8|Stage II Pancreatic Cancer AJCC v8|Stage IIA Pancreatic Cancer AJCC v8|Stage IIB Pancreatic Cancer AJCC v8
Interventions: DRUG: Pyrvinium Pamoate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Clinical Performance of the DREAMS 3G Resorbable Magnesium Scaffold System
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease|Atherosclerosis, Coronary|Myocardial Ischemia|Ischemic Heart Disease|Acute Coronary Syndrome|Angina Pectoris
Interventions: DEVICE: DREAMS 3G RMS|DEVICE: Xience DES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapies for Recovery of Hand Function After Stroke
Status: ACTIVE_NOT_RECRUITING
Conditions: Stroke|Upper Extremity Paresis|Hemiplegia
Interventions: DEVICE: Electrical Stimulator|BEHAVIORAL: Occupational Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Skin Conductance Measurement as an Endpoint Monitor for Sympathetic Blocks
Status: COMPLETED
Conditions: Nerve; Disorder, Sympathetic
Interventions: PROCEDURE: Lumbar Sympathetic Block|DEVICE: Skin conductance algesimeter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Recommendations and Alerting for Delirium Alleviation in Real-Time (RADAR)
Status: COMPLETED
Conditions: Delirium
Interventions: BEHAVIORAL: Family Support System|BEHAVIORAL: HELP Support System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interaction of SHR1459 With a Strong CYP3A Index Inducer (Rifampicin)
Status: COMPLETED
Conditions: Healthy Subjects, Drug-drug Interaction, Pharmacokinetics, SHR1459
Interventions: DRUG: Rifampin|DRUG: SHR1459
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promotion of Oesophageal Motility to Prevent Regurgitation and Enhance Nutrition Intake in ICU Patients.
Status: COMPLETED
Conditions: Critically Ill|Malnutrition
Interventions: DEVICE: E-Motion System|DEVICE: Sham E-Motion System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose Proportionality Study About Amaryl M Slow Release (SR) 1/500 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Amaryl M SR 1/500 mg|DRUG: Amaryl M SR 2/500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Clinical Trial of Freeze-dried Human Rabies Vaccine (MRC-5 Cells)
Status: COMPLETED
Conditions: Rabies Vaccine Adverse Reaction
Interventions: BIOLOGICAL: Freeze-dried human rabies vaccine (MRC-5 cells) Zhifeilongkoma - 5-dose program|BIOLOGICAL: Freeze-dried human rabies vaccine (MRC-5 cells) Zhifeilongkoma - 4-dose program|BIOLOGICAL: Freeze-dried human rabies vaccine (MRC-5 cells) Kanghua - 5-dose program|BIOLOGICAL: Freeze-dried human rabies vaccine (MRC-5 cells) Kanghua - 4-dose program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Pembrolizumab/Vibostolimab (MK-7684A) in Combination With Concurrent Chemoradiotherapy Followed by Pembrolizumab/Vibostolimab Versus Concurrent Chemoradiotherapy Followed by Durvalumab in Participants With Stage III Non-small Cell Lung Cancer (MK-7684A-006/KEYVIBE-006)
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: BIOLOGICAL: pembrolizumab/vibostolimab|BIOLOGICAL: durvalumab|DRUG: cisplatin|DRUG: pemetrexed|DRUG: etoposide|DRUG: carboplatin|DRUG: paclitaxel|RADIATION: thoracic radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Safety of the Approved Product Empedic L Cream During Its Routine Use (Active Ingredient is Clotrimazole 1%)
Status: COMPLETED
Conditions: Vaginal Candida
Interventions: DRUG: Clotrimazole 1% (Empecid L Cream, BAYB5097)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Study to Evaluate the Maximum Tolerated Dose of BAY79-4620 Given Every 2 Weeks to Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Neoplasms
Interventions: DRUG: BAY79-4620
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Acetaminophen Use for Pain Reduction in Electrophysiology Procedures
Status: UNKNOWN
Conditions: Post Electrophysiology Procedure Pain
Interventions: DRUG: Acetaminophen|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Ovarian Response to Recombinant Follicle Stimulating Hormone in Women With PCOS
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Healthy|Anovulation|Hyperandrogenism
Interventions: DRUG: Recombinant Follicle Stimulating Hormone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: REALIB-LLA-2017: Idelalisib in Patients With Acute Lymphoblastic Leukemia
Status: TERMINATED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Idelalisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: QT Intervals Study to Compare the Acute Effects of Orally Inhaled Dihydroergotamine (DHE), Oral Moxifloxacin, and Placebo
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: MAP0004|DRUG: Inhaler Placebo|DRUG: Moxifloxacin|DRUG: Placebo Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risperidone Long-acting Versus Oral Risperidone in Patients With Schizophrenia and Alcohol Use Disorder
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders|Substance Abuse|Alcohol Abuse
Interventions: DRUG: Risperidone Long Acting|DRUG: oral risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VR-Based Preoperative Rehabilitation Program for Patients Undergoing Anterior Cruciate Ligament (ACL) Reconstruction
Status: RECRUITING
Conditions: Anterior Cruciate Ligament (ACL) Reconstruction|Preoperative Rehabilitation
Interventions: PROCEDURE: The VR-based preoperative rehabilitation program;|PROCEDURE: standard nursing care,
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of iGel and THRIVE on Bronchoscopic Interventions
Status: COMPLETED
Conditions: Lung Diseases|Total Intravenous Anesthesia|Tracheal Diseases
Interventions: PROCEDURE: The responses to bronchoscopic insertion for bronchoscopic interventions such asTBNA, Cryotherapy, etc.|PROCEDURE: postoperative recovery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Cold Atmospheric Plasma on Malassezia Folliculitis
Status: COMPLETED
Conditions: Malassezia Folliculitis
Interventions: DEVICE: Cold atmospheric plasma treatment device|DRUG: Itraconazole Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase Ⅰa Clinical Study of Hawthorn Red Pigment Combined With Standard Analgesic for Refractory Cancer Pain
Status: UNKNOWN
Conditions: Hawthorn Red Combined Refractory Cancer Pain
Interventions: DRUG: Hawthorn red pigment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Intravenous Mircera in Participants With Chronic Renal Anemia Who Are on Dialysis
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Methoxy polyethylene glycol-epoetin beta
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polarized Dendritic Cell (aDC1) Based Treatment, Interferon Alpha-2, Rintatolimod, and Celecoxib for the Treatment of HLA-A2+ Refractory Melanoma
Status: RECRUITING
Conditions: HLA-A2 Positive Cells Present|Refractory Melanoma
Interventions: BIOLOGICAL: Alpha-type-1 Polarized Dendritic Cells|DRUG: Celecoxib|DRUG: PD-1 Ligand Inhibitor|DRUG: PD1 Inhibitor|BIOLOGICAL: Recombinant Interferon Alfa-2b|DRUG: Rintatolimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aprepitant Plus Granisetron and Dexamethasone for the Prevention of Vomiting in Patients With HAIC Therapy for HCC
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Aprepitant in combination with granisetron and dexamethasone|DRUG: Granisetron and dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose Escalating Study for Amphinex-based PCI of Bleomycin.
Status: COMPLETED
Conditions: Cutaneous or Sub-cutaneous Malignancies
Interventions: DRUG: Amphinex|DRUG: Bleomycin|DEVICE: Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Employment Support After Hematopoietic Stem Cell Transplantation
Status: NOT_YET_RECRUITING
Conditions: Hematopoietic Stem Cell Transplantation
Interventions: BEHAVIORAL: Work Support (WorkS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Intralesional Administration of MK-4621 (RGT100) in Adult Participants With Advanced or Recurrent Tumors (MK-4621-001/RGT100-001)
Status: TERMINATED
Conditions: Advanced Solid Tumors
Interventions: DRUG: MK-4621
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaginal Estradiol Tablets (Vagifem®) and Endometrial Cancer Risk in the Treatment of Postmenopausal Vaginal Atrophy
Status: COMPLETED
Conditions: Postmenopausal Vaginal Atrophy
Interventions: DRUG: Vagifem®|DRUG: Non-Vagifem® LDVE, Estradiol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Study of NC318 Alone or in Combination With Pembrolizumab in Patients With Advanced Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Advanced Non-small Cell Lung Cancer
Interventions: DRUG: NC318 800 mg|DRUG: NC318 400 mg|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Effects of Intranasal JNJ-17166864 on Symptoms of Allergic Rhinitis in Adults
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: JNJ-17166864|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Adherence to Antihypertensive Drugs and Statins by Hair Analysis
Status: UNKNOWN
Conditions: Arterial Hypertension|Dyslipidemias|Antihypertensive Drugs|Statins|Treatment Adherence
Interventions: DIAGNOSTIC_TEST: Hair analysis for drug concentration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Activated Recombinant Human Factor VII in Severely Injured Trauma Patients
Status: COMPLETED
Conditions: Acquired Bleeding Disorder|Trauma
Interventions: DRUG: activated recombinant human factor VII|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pre- and Post-operative FOLFOX Based Therapy for Patients With Colorectal Cancer With Liver Involvement
Status: TERMINATED
Conditions: Colorectal Cancer|Metastases
Interventions: DRUG: Cetuximab|DRUG: Bevacizumab|DRUG: Leucovorin|DRUG: Oxaliplatin|DRUG: Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodal HIIT in Speed, Agility and Performance Level
Status: RECRUITING
Conditions: High Intensity Interval Training
Interventions: OTHER: Multimodal HIIT|OTHER: conventional HIIT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Acupuncture for Total Knee or Hip Arthroplasty
Status: COMPLETED
Conditions: Knee Arthropathy|Hip Arthropathy|Anxiety
Interventions: DEVICE: Acupuncture needles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Transcutaneous Posterior Tibial Nerve Stimulation for Premature Ejaculation
Status: RECRUITING
Conditions: Premature Ejaculation
Interventions: OTHER: Transcutaneous posterior tibial nerve stimulation|DRUG: Paroxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Remediation in 22q11DS
Status: COMPLETED
Conditions: 22q11.2 Deletion Syndrome|Velo-Cardio-Facial Syndrome
Interventions: BEHAVIORAL: Cognitive remediation program|BEHAVIORAL: Small group social skills training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Exercise and Compression for Lymphedema
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer Related Lymphedema
Interventions: DEVICE: Compression sleeve, worn during exercise|DEVICE: Adjustable Compression (AC) garment, worn during exercise|DEVICE: Compression sleeve, daytime wear|BEHAVIORAL: Decongestive Progressive Resistance Exercise program|BEHAVIORAL: Home exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting
Status: UNKNOWN
Conditions: Carotid Stenosis
Interventions: DRUG: Clopidogrel|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Early Behavioral and Transaction Interventions on Preterm Infants' and Parents' Biopsychosocial Well-being
Status: COMPLETED
Conditions: Early Interventions|Preterm Infants|Parent-Child Relations
Interventions: BEHAVIORAL: BS|BEHAVIORAL: Routine care|BEHAVIORAL: PITP|BEHAVIORAL: BS+PITP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of the Immunogenicity of Vaccination With Multiple Synthetic Melanoma Peptides With Granulocyte-macrophage Colony-stimulating Factor (GM-CSF)-In-Adjuvant, in Patients With Advanced Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: 4-peptide and 12-peptide melanoma vaccines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect and Feasibility of Non-linear Periodized Resistance Training in People With COPD
Status: COMPLETED
Conditions: Pulmonary Disease|Chronic Obstructive
Interventions: OTHER: Non-linear Periodized Resistance Training|OTHER: Resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: This is a Study to Evaluate the Pharmacokinetics and Safety of IBI362 in Chinese Adolescents With Obesity
Status: NOT_YET_RECRUITING
Conditions: Adolescents With Obesity
Interventions: DRUG: IBI362|DRUG: IBI362 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ticagrelor and Eptifibatide Bolus-Only Versus Ticagrelor and Eptifibatide Bolus Plus Abbreviated Infusion
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Ticagrelor|DRUG: Eptifibatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Ribavirin and Low Dose Ara-C to Treat Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Ribavirin|DRUG: Cytarabine arabinoside
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of LATISSE® in the Augmentation of Eyelashes of Korean Subjects
Status: COMPLETED
Conditions: Eyelash Hypotrichosis
Interventions: DRUG: bimatoprost 0.03%
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Investigate the Efficacy, Tolerability and Safety of Fesoterodine Sustained Release in Subjects With Overactive Bladder Syndrome
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: SPM 907
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: Malaria Infection Diagnosed by Polymerase Chain Reaction (PCR) as a Means of Evaluating Pre-erythrocytic Candidate Malaria Vaccines
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: FP9 ME-TRAP|BIOLOGICAL: MVA ME-TRAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201)
Status: RECRUITING
Conditions: Glioblastoma|High-grade Glioma|Glioblastoma, IDH-wildtype|Glioblastoma, IDH-mutant|Glioblastoma Multiforme, Adult|Astrocytoma, Grade IV|Astrocytoma, Grade III|Astrocytoma, Malignant|Brain Neoplasms|Brain Neoplasm, Primary|Brain Neoplasms, Adult|Brain Neoplasm, Malignant
Interventions: PROCEDURE: Supramaximal resection|PROCEDURE: Maximal safe resection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MGCD290 and Fluconazole Versus Fluconazole Alone for the Treatment of Moderate to Severe Vulvovaginal Candidiasis
Status: COMPLETED
Conditions: Vulvovaginal Candidiasis
Interventions: DRUG: MGCD290
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intrathecal Neostigmine on Post-dural Puncture Headache.
Status: COMPLETED
Conditions: Post-Dural Puncture Headache
Interventions: DRUG: Neostigmine Methylsulfate|DRUG: Dextrose 5%/Nacl 0.9% Inj
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: In Situ Caries of Fluoride Toothpastes
Status: COMPLETED
Conditions: Healthy Subjects|Partial Denture Wearers|Caries
Interventions: DRUG: Sodium fluoride toothpaste|DRUG: Placebo toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fasting Study of Olmesartan Medoxomil Tablets 40 mg and Benicar® Tablets 40 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Olmesartan Medoxomil Tablets 40 mg|DRUG: Benicar® Tablets 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Radiotherapy,Chemotherapy,Before and After Surgery in Advanced Esophageal or Gastroesophageal Junction Cancer
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: cisplatin|DRUG: fluorouracil|DRUG: Iressa|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-dose Vaginal Dinoprostone and Hysterectomy
Status: COMPLETED
Conditions: Hysterectomy
Interventions: DRUG: Dinoprostone 3 mg|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MYocarditis and/or Pericarditis Following mRNA COVID-19 VACCination National Surveillance Study
Status: RECRUITING
Conditions: Myocarditis|Myocarditis Acute|Pericarditis|Pericarditis Acute
Interventions: DIAGNOSTIC_TEST: Stand of care ECG, Holter, MRI, ECHO, Quality of life questionnaire|OTHER: Baseline Quality of Life questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Trial of an Quadrivalent Inactivated Influenza Vaccine in Healthy Children Aged 6 to 35 Months
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: quadrivalent influenza split vaccine|BIOLOGICAL: quadrivalent influenza split vaccine|BIOLOGICAL: Influenza virus split vaccine|BIOLOGICAL: Influenza virus split vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, PK and Efficacy of NOX66 as a Monotherapy and Combined With Carboplatin in Refractory Solid Tumours
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: NOX66|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glucocorticoids Withdrawal in Early Systemic Lupus Erythematosus
Status: UNKNOWN
Conditions: Systemic Lupus Erythematosus|Glucocorticoids|Therapy Withdrawal
Interventions: DRUG: oral Prednisone 5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN)
Status: COMPLETED
Conditions: Anemia, Cooley's|Beta-Thalassemia|Hematologic Diseases|Thalassemia|Osteoporosis|Iron Overload|Hypertension, Pulmonary
Interventions: DRUG: Deferoxamine|DRUG: Deferiprone|DRUG: Arginine|DRUG: Sildenafil|DRUG: Decitabine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Taurine in Patients With First-episode Psychosis Receiving Antipsychotic Treatment
Status: COMPLETED
Conditions: Psychotic Disorders
Interventions: DRUG: Taurine 4g
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of On-Line Hemodiafiltration Versus High Flux Hemodialysis on Hemodynamic Parameters in Patients With Intra-Dialytic Hypotension
Status: COMPLETED
Conditions: Intradialytic Hypotension
Interventions: DEVICE: NICaS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Proprioceptive Training Using Head Mounted Laser in Chronic Mechanical Neck Pain
Status: COMPLETED
Conditions: Mechanical Neck Pain
Interventions: OTHER: Proprioceptive training using head mounted laser|OTHER: Conventional Physical therpay
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dynamic SAX vs Conventional LAX in Radial Artery Cannulation.
Status: COMPLETED
Conditions: Cardiac Surgical Procedures|Catheterization|Ultrasonography
Interventions: PROCEDURE: Dynamic needle tip positioning under ultrasound-guidance|PROCEDURE: Conventional long-axis view
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: One-hour Troponin in a Low-prevalence Population of Acute Coronary Syndrome
Status: COMPLETED
Conditions: Non-ST Elevation Myocardial Infarction|Acute Coronary Syndrome|Angina, Unstable|NSTEMI - Non-ST Segment Elevation MI
Interventions: PROCEDURE: 1-hour hs-cTnT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Of Yttrium-ibritumomab (Zevalin) For the Treatment Of Patients With Relapsed And Refractory Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Mantle-Cell
Interventions: DRUG: Yttrium-ibritumomab (Zevalin)|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Reslizumab in Patients With Eosinophilic Asthma
Status: COMPLETED
Conditions: Eosinophilic Asthma
Interventions: DRUG: Reslizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of t-RFA and RF-TVA Prior to/Following Radiation Therapy to Treat Painful Metastatic Vertebral Body Tumor(s)
Status: TERMINATED
Conditions: Metastatic Lesions in Vertebral Bodies
Interventions: DEVICE: STAR™ Tumor Ablation System|DEVICE: StabiliT® Vertebral Augmentation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate THR-317 and Ranibizumab Combination Treatment for Diabetic Macular Oedema (DME)
Status: COMPLETED
Conditions: Diabetes Mellitus|Diabetic Retinopathy|Macular Edema
Interventions: DRUG: Ranibizumab 0.5mg|DRUG: THR-317 8mg|DRUG: Sham injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Aflibercept, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma Multiforme, Gliosarcoma, or Other Malignant Glioma
Status: COMPLETED
Conditions: Adult Anaplastic Astrocytoma|Adult Anaplastic Oligodendroglioma|Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Adult Mixed Glioma|Recurrent Adult Brain Tumor
Interventions: DRUG: ziv-aflibercept|PROCEDURE: radiation therapy|DRUG: temozolomide|PROCEDURE: pharmacological study|PROCEDURE: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Phase II Study on the Optimization of Immunotherapy in Squamous Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck|Carcinoma, Squamous Cell of Head and Neck
Interventions: DRUG: Nivolumab and Ipilimumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study of Pegylated Liposomal Doxorubicin Contrast Epirubicin for the Treatment of Diffuse Large B-cell Lymphoma
Status: UNKNOWN
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: PL-doxorubicin and epirubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Trofinetide for the Treatment of Girls and Women With Rett Syndrome (LAVENDER™)
Status: COMPLETED
Conditions: Rett Syndrome
Interventions: DRUG: Trofinetide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of DAILIES TOTAL 1® Multifocal Compared to 1-Day Acuvue® Moist® Multifocal in a Japanese Population
Status: COMPLETED
Conditions: Refractive Error|Presbyopia
Interventions: DEVICE: Delefilcon A multifocal contact lenses|DEVICE: Etafilcon A multifocal contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Usage of Soda-Water in Gastric Preparation for Magnetically Controlled Capsule Endoscopy
Status: COMPLETED
Conditions: Gastric Disease|Capsule Endoscopy
Interventions: PROCEDURE: Soda-water instead of pure water to observe gastric filling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: ENDOblock: Bilateral Superficial Cervical Blocks With Local Wound Infiltration in Thyroid Surgery
Status: RECRUITING
Conditions: Post Operative Pain|Nausea and Vomiting, Postoperative|Opioid Use
Interventions: PROCEDURE: bilateral superficial cervical plexus blocks and local wound infiltration|PROCEDURE: placebo injection and local wound infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Open Label Study of L059 Intravenous (IV) in Japanese Epilepsy Subjects With Partial Onset Seizures
Status: COMPLETED
Conditions: Epilepsy|Partial Onset Seizures
Interventions: DRUG: Levetiracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety of THR-687 in Subjects With Diabetic Macular Edema (DME)
Status: COMPLETED
Conditions: Diabetes Mellitus|Diabetic Retinopathy|Diabetic Macular Edema
Interventions: DRUG: THR-687 dose level 1|DRUG: THR-687 dose level 2|DRUG: THR-687 dose level 3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tocilizumab and Tofacitinib in the Treatment of Vascular Behçet's Syndrome
Status: RECRUITING
Conditions: Aneurysm|Behcet Syndrome, Vascular Type
Interventions: DRUG: tocilizumab|DRUG: tofacitinib|DRUG: cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vorinostat, Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Stage I Chronic Lymphocytic Leukemia|Stage I Small Lymphocytic Lymphoma|Stage II Chronic Lymphocytic Leukemia|Stage II Small Lymphocytic Lymphoma|Stage III Chronic Lymphocytic Leukemia|Stage III Small Lymphocytic Lymphoma|Stage IV Chronic Lymphocytic Leukemia|Stage IV Small Lymphocytic Lymphoma
Interventions: DRUG: Fludarabine Phosphate|DRUG: Cyclophosphamide|BIOLOGICAL: Rituximab|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Slotted Hole Versus Fixed Hole C-Tek
Status: TERMINATED
Conditions: Herniated Disc|Radiculopathy|Spondylolysis
Interventions: DEVICE: Fixed hole C-Tek™ Plate|DEVICE: Slotted hole C-Tek™ Plate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT