pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Transanal Inspection and Management of Low ColoRectal Anastomosis Performed With a New Technique
Status: COMPLETED
Conditions: Anastomotic Leak
Interventions: PROCEDURE: Transanal Inspection and management of low ColoRectal Anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Efficacy of Odanacatib (MK-0822) in Postmenopausal Women Previously Treated With a Bisphosphonate (MK-0822-042)
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Odanacatib|DRUG: Placebo|DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effects of Telerehabilitation Groups for Chronic Non-specific Low Back Pain.
Status: COMPLETED
Conditions: Chronic Non-specific Low Back Pain
Interventions: OTHER: Real-time synchronized telerehabilitation program (STP).|OTHER: Pre-recording non-synchronized telerehabilitation program (NSTP)|OTHER: Home non-supervised control group (HCG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Combining Whole Body Vibration Training With Plyometric Jumping on the Neuromuscular Adaptations of Human Triceps Surae Muscles
Status: UNKNOWN
Conditions: Muscle Force, Explosive Strength and Vertical Jump Height
Interventions: OTHER: vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose:
Clinical trial: The Effect of Collagen Matrix Graft on Postoperative Palatal Fistula Formation After Cleft Palate Repair
Status: RECRUITING
Conditions: Cleft Lip and Cleft Palate|Cleft Lip, Cleft Alveolus and Cleft Palate|Cleft Palate
Interventions: PROCEDURE: Two-flap palatoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intervention for Improving Psychological Distress in Dialysis
Status: COMPLETED
Conditions: Kidney Failure, Chronic|Depression|Anxiety
Interventions: BEHAVIORAL: Computerised Cognitive Behavioural Therapy|BEHAVIORAL: Telephone support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Melatonin for Prevention of Radiation Induced Oral Mucositis
Status: COMPLETED
Conditions: Oral Mucositis (Ulcerative) Due to Radiation
Interventions: DIETARY_SUPPLEMENT: Rapid Release Capsules Melatonin, 10 mg|DRUG: Miconaz oral gel|DRUG: BBC oral spray|DRUG: Oracure gel|OTHER: Alkamisr sachets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bronchodilator Effect of RPL554 Administered in Addition to Tiotropium/Olodaterol in Patients With COPD
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: RPL554 Suspension|DRUG: Placebo|DRUG: Tiotropium/olodaterol (Respimat)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Impact of Respiratory-Swallow Training on Refractory Dysphagia in Oropharyngeal Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer|Dysphagia
Interventions: BEHAVIORAL: Respiratory Swallow Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Topical Capsaicin in Painful Diabetic Neuropathy
Status: COMPLETED
Conditions: Diabetic Polyneuropathy
Interventions: DRUG: Capsaicin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Research Study With Clazosentan to Evaluate Its Effects on Preventing Complications Due to the Narrowing of the Blood Vessels (Vasospasm) in the Brain, Caused by Bleeding Onto the Surface of the Brain
Status: COMPLETED
Conditions: Aneurysmal Subarachnoid Hemorrhage
Interventions: DRUG: Clazosentan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Exploratory Study to Assess the Efficacy and Safety of TC-5214 in the Treatment of Subjects With Palmar Hyperhidrosis
Status: COMPLETED
Conditions: Palmar Hyperhidrosis
Interventions: DRUG: Dexmecamylamine HCl|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Adalimumab in Patients With Psoriasis and Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Psoriasis|Sleep Apnea, Obstructive
Interventions: DRUG: Adalimumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of Pazopanib and Cyclophosphamide in Patients With Platinum-resistant Recurrent Ovarian Cancer
Status: COMPLETED
Conditions: Epithelial Ovarian Cancer
Interventions: DRUG: Pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Plasma Exchange Compared to Standard Medical Therapy in Patients With Severe Drug Induced Liver Injury With or Without Underlying Chronic Liver Disease.
Status: UNKNOWN
Conditions: Chronic Liver Disease
Interventions: BIOLOGICAL: High Volume Plasma Exchange|OTHER: Standard Medical Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ocrelizumab in Participants With Primary Progressive Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis, Primary Progressive
Interventions: DRUG: Ocrelizumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Photobiomodulation for Lower Back Pain Post Spinal Fusion and Decompression Surgery
Status: RECRUITING
Conditions: Spinal Fusion|Chronic Lower Back Pain
Interventions: DEVICE: Laser Diode Brace|DEVICE: Sham Laser Diode Brace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on SBRT for Inoperable Lung and Liver Oligometastases From Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer|Metastasis to Liver|Metastasis to Lung
Interventions: RADIATION: stereotactic radiation therapy (SRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dapagliflozin on LV Remodeling Post AMI
Status: RECRUITING
Conditions: Myocardial Infarction
Interventions: DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antiviral Activity of Oral Probiotics
Status: UNKNOWN
Conditions: Lower Respiratory Tract Infection|Upper Respiratory Tract Infection
Interventions: DIETARY_SUPPLEMENT: Streptococcus salivarius K12 Powder 1 Billion colony forming units /g)|DIETARY_SUPPLEMENT: Streptococcus salivarius K12 Powder (1 Billion colony forming units /g) with a prebiotic included|DIETARY_SUPPLEMENT: Streptococcus salivarius M18 Powder (1 Billion colony forming units /g)|DIETARY_SUPPLEMENT: Streptococcus salivarius M18 Powder (1 Billion colony forming units /g) with a prebiotic included
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study on the Safety and Effectiveness of Rilpivirine Hydrochloride (Edurant) Among Adult Filipino Patients With Human Immunodeficiency Virus Type-I Infection
Status: WITHDRAWN
Conditions: Human Immunodeficiency Virus Type 1 (HIV-1) Infection
Interventions: DRUG: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: BIO|CONCEPT.ECG-Library
Status: TERMINATED
Conditions: Heart Diseases|Rhythm; Abnormal
Interventions: DIAGNOSTIC_TEST: 3-channel Holter ECG recording|DIAGNOSTIC_TEST: 12-channel Holter ECG recording
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography
Status: UNKNOWN
Conditions: Acute on Chronic Liver Failure|Cirrhosis
Interventions: DEVICE: Thromboelastography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Preventive Treatment Approach of Early Caries Lesions With Contemporary Methods of Remineralization
Status: COMPLETED
Conditions: Tooth Decay
Interventions: DEVICE: Fluoride Varnish|DEVICE: Curodont Repair|DEVICE: Curodont Protect
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: To Compare Efficacy and Safety of Lactulose Versus Polyethylene Glycol for Treatment of Overt Hepatic Encephalopathy in Cirrhotics.
Status: UNKNOWN
Conditions: Cirrhosis
Interventions: DRUG: PEG- 17 gm sachet|DRUG: Lactulose : 20-30gm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Multicomponent Training Versus Cardiovascular Training as a Treatment for Hypertension in Adult Subjects
Status: COMPLETED
Conditions: Hypertension
Interventions: OTHER: Multi-component training|OTHER: Continuous Cardiovascular Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Generic Formulations of Commonly-used Oral Drugs in Saudi Arabia:Interchangeability & Post-marketing Quality
Status: COMPLETED
Conditions: Generic Drug Quality|Generic Formulation Interchangeability
Interventions: DRUG: one of the 15 drugs listed below|DRUG: one of the 15 drugs listed below|DRUG: one of the 15 drugs listed below|DRUG: one of the 15 drugs listed below
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Renoprotective Effect of Nisoldipine and Lisinopril in Type 1 Diabetic Nephropathy
Status: COMPLETED
Conditions: Diabetic Nephropathy
Interventions: DRUG: nisoldipine|DRUG: lisinopril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Use of an Electronic Medical Record in the Primary Care Setting to Improve Herpes Zoster Vaccination Rates
Status: COMPLETED
Conditions: Herpes Zoster Disease
Interventions: OTHER: An informational packet regarding shingles and the HZV was sent to patients identified by the EMR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Value of Flow Cytometry in Infectious Point of Care: Feasibility Study
Status: COMPLETED
Conditions: A Potential Infectious Respiratory Clinical Syndrome|Potential Clinical Urinary Infectious Syndrome|A Potential Clinical Abdominal Infection Syndrome
Interventions: OTHER: Value of Flow Cytometry in Infectious Point of Care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Levosimendan in Patients With Impaired Right Ventricular Function Undergoing Cardiac Surgery
Status: UNKNOWN
Conditions: Right Heart Failure|Open-heart Surgery
Interventions: DRUG: Levosimendan|DRUG: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stryker PEEK Customized Implant: A Prospective Post Market Follow Up to Evaluate Safety, Performance and Effectiveness
Status: ENROLLING_BY_INVITATION
Conditions: Cranioplasty|Craniofacial Abnormalities|Craniofacial Injuries
Interventions: DEVICE: Stryker's PEEK Customized Implant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Calcineurin Inhibitor-Free Immunosuppression in Renal Transplant Recipients at Low Immunogenic Risk
Status: COMPLETED
Conditions: Renal Transplant Recipients
Interventions: DRUG: Zenapax®, CellCept® and prednisolone|DRUG: Sandimmun Neoral®, CellCept® and prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Single Oral Doses of Lasmiditan When Coadministered With Single Oral Doses of Sumatriptan in Healthy Participants
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: lasmiditan 200 mg|DRUG: Sumatriptan|DRUG: matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cervical Stabilization in Individuals With Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Craniocervical flexion training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Premedication Type on Preoperative Anxiety in Children
Status: COMPLETED
Conditions: Preoperative Anxiety
Interventions: OTHER: oral midazolam|OTHER: Film http://www.animaturk.com/animasyon/suko-ameliyat-oluyor.|OTHER: Playing smartphone game
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Efficacy and Compliance of the Mandibular Advancement Devices ONIRIS® vs. Custom Made Devices
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: ONIRIS®|DEVICE: TALI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quartet Lead With Defibrillator Multisite Algorithmic Cardiac Resynchronisation Therapy Optimisation
Status: WITHDRAWN
Conditions: Heart Failure, Systolic
Interventions: OTHER: Algorithmic Cardiac Resynchronisation Therapy Optimisation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Control of Asthma Patients Symptomatic on Inhaled Corticosteroids
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: IPL512,602 20 mg once daily|DRUG: IPL512,602 Matching Placebo once daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Double-blind, Placebo-controlled Study of OPC-41061 in the Treatment of Cardiac Edema (Congestive Heart Failure)
Status: COMPLETED
Conditions: Edema, Cardiac
Interventions: DRUG: OPC-41061(Tolvaptan)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Riboflavin at 4ºC for the Management of Pain After Crosslinking for Keratoconus Patients
Status: UNKNOWN
Conditions: Keratoconus|Crosslinking
Interventions: PROCEDURE: corneal collagen crosslinking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Sensitivity With and Without Sonic Activation of a Desensitizing Gel Before in Office Bleaching in Adults
Status: COMPLETED
Conditions: Dentin Sensitivity|Tooth Bleaching
Interventions: OTHER: With sonic activation (SMART Device®)|OTHER: Control (Without sonic activation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sorafenib and Bavituximab Plus SBRT in Unresectable Hepatocellular Carcinoma
Status: WITHDRAWN
Conditions: HepatoCellular Carcinoma|Unresectable HepatoCellular Carcinoma|Liver Cancer
Interventions: RADIATION: Stereotactic Body Radiation Therapy (SBRT)|DRUG: Sorafenib|DRUG: Bavituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Satraplatin and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Satraplatin in combination with Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In Children, Does Using a Synera Patch Decrease Pain When Injecting Propofol at Anesthesia Induction?
Status: UNKNOWN
Conditions: Pain on Propofol IV Injection
Interventions: DEVICE: lidocaine/tetracaine transdermal patch (NDC 43469-864-01)|DRUG: Gebauer's Ethyl Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Thorough QTc Trial Evaluating the Effect of SNAC on Cardiac Repolarisation in Healthy Male Subjects.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: SNAC|DRUG: Placebo|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study on Efficacy and Safety of add-on Sulforaphane or rTMS to Escitalopram for Major Depressive Disorder With Poor Response to Initial Treatment
Status: UNKNOWN
Conditions: Major Depressive Disorder
Interventions: DIETARY_SUPPLEMENT: Escitalopram+Sulforaphane|DEVICE: Escitalopram+rTMS|DRUG: Escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stearoyl-CoA Desaturase and Energy Metabolism in Humans
Status: COMPLETED
Conditions: Healthy|Obesity
Interventions: BEHAVIORAL: PUFA-Cys/Met diet|BEHAVIORAL: SFA+Cys/Met diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Application of Ketamine for Sedation in Patients With Cardiac Arrest - - KetCat (KETamine in Cardiac ArresT) Study
Status: RECRUITING
Conditions: Cardiac Arrest, Out-Of-Hospital|Ketamine|Neurologic Manifestations
Interventions: DRUG: Ketamine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of a Novel Intervention Using Daily Intermittent Hypoxia and High Intensity Training on Upper Limb Function in Individuals With Spinal Cord Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Cord Injuries
Interventions: COMBINATION_PRODUCT: Upper extremity training/Armeo Spring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Sunitinib Scheduling in Metastatic Renal Cell Carcinoma (mRCC)
Status: COMPLETED
Conditions: Genitourinary Cancer|Kidney Cancer
Interventions: DRUG: Sunitinib|BEHAVIORAL: Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conjugate Vaccine Against Meningococcus C a Brazilian Project
Status: UNKNOWN
Conditions: Serogroup C Meningococcal Meningitis
Interventions: BIOLOGICAL: MenCC-BIO Vaccine|BIOLOGICAL: Combined - CRM197
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Phacoemulsification and Corneal Damage Between FLACS and Standard Phaco With Two Handpieces
Status: RECRUITING
Conditions: Corneal Endothelial Cell Loss|Cataract|Astigmatism
Interventions: DEVICE: Femtosecond laser assisted cataract surgery with Active Sentry handpiece|PROCEDURE: Standard phacoemulsification with the Active Sentry handpiece|PROCEDURE: Standard phacoemulsification with the OZil handpiece
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study Evaluating Surgery for Mesothelioma After Radiation Therapy Using Extensive Pleural Resection
Status: ACTIVE_NOT_RECRUITING
Conditions: Mesothelioma; Lung
Interventions: RADIATION: Varying Doses of Background and Boost RT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electromagnetic Field Therapy to Improve Healing of Chronically Venous Ulcer
Status: UNKNOWN
Conditions: Chronic Venous Hypertension With Ulcer and Inflammation|Venous Ulcer Pain
Interventions: DEVICE: Active Pulsed Electro-Magnetic Field (PEMF)|DEVICE: Placebo Pulsed Electro-Magnetic Field (PEMF)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial of Durvalumab (MEDI 4736) in Combination With Extended Neoadjuvant Regimens in Rectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Rectal Cancer|Rectal Adenocarcinoma|Rectal Neoplasms
Interventions: DRUG: Durvalumab|DRUG: FOLFOX|RADIATION: Short Course Radiotherapy (Arm A)|RADIATION: Long course chemoradiation (Arm B)|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Investigate the Effect of Teduglutide on Temporary Ileostomy Function and Complications
Status: WITHDRAWN
Conditions: Ileostomy - Stoma
Interventions: DRUG: Teduglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Brain Responses to Intragastric Administration of a Bitter Agonist in Homeostatic and Hedonic Brain Regions
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Quinine hydrochloride|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trabectedin, Doxorubicin and Olaratumab in Patients With Metastatic or Recurrent Leiomyosarcoma
Status: WITHDRAWN
Conditions: Leiomyosarcoma
Interventions: DRUG: Trabectedin|DRUG: Doxorubicin|DRUG: Olaratumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Veteran Stress and Learning Study
Status: COMPLETED
Conditions: Stress Disorders, Posttraumatic
Interventions: DRUG: Hydrocortisone|DRUG: D-Cycloserine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Internal Rotation Resistance Test at Abduction and External Rotation
Status: COMPLETED
Conditions: Rotator Cuff Tears
Interventions: DIAGNOSTIC_TEST: IRRTM|DIAGNOSTIC_TEST: the lift-off test|DIAGNOSTIC_TEST: the belly-press test|DIAGNOSTIC_TEST: the IRLS test|DIAGNOSTIC_TEST: the bear-hug test|DIAGNOSTIC_TEST: IRRT 0°|DIAGNOSTIC_TEST: Diagnostic arthroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy, Tolerability and Safety of Intramuscular Injections of PLX PAD for the Treatment of Subjects With Critical Limb Ischemia (CLI) With Minor Tissue Loss Who Are Unsuitable for Revascularization
Status: COMPLETED
Conditions: Critical Limb Ischemia (CLI)
Interventions: BIOLOGICAL: PLX-PAD|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Engineered NK Cells Containing Deleted TGF-BetaR2 and NR3C1 for the Treatment of Recurrent Glioblastoma
Status: RECRUITING
Conditions: Recurrent Gliosarcoma|Recurrent Supratentorial Glioblastoma|Supratentorial Gliosarcoma
Interventions: BIOLOGICAL: Cord Blood-derived Expanded Allogeneic Natural Killer Cells|PROCEDURE: Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ITI Using SCT800 Alone or Combining Daratumumab in Hemophilia A Adolescents and Adults With High Titer Inhibitor
Status: RECRUITING
Conditions: Hemophilia A With Inhibitor
Interventions: DRUG: SCT800 and Daratumumab|DRUG: SCT800
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel-Carboplatin-Bevacizumab +/- Nitroglycerin in Metastatic Non-Squamous-Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: carboplatin paclitaxel bevacizumab|DRUG: Standard treatment plus nitroglycerin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mission Connect Mild Traumatic Brain Injury (TBI) Integrated Clinical Protocol
Status: TERMINATED
Conditions: Traumatic Brain Injury|Post-traumatic Stress Disorder
Interventions: DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of BTX-9341 in Advanced and/or Metastatic Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: BTX-9341|DRUG: Fulvestrant|DRUG: BTX-9341
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of The Postprandial Impact of Automated Priming Bolus for Full Closed Loop Insulin Delivery
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: FCL+BPS|DEVICE: FCL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Chest CT With Iterative Reconstruction as an Alternative to Conventional Chest X-ray Prior to Heart Surgery
Status: TERMINATED
Conditions: Cardiac Defects|Disorder; Heart, Functional, Postoperative, Cardiac Surgery|Stroke
Interventions: OTHER: CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Temozolomide and Ascorbic Acid in Treating Patients With Recurrent High-Grade Glioma
Status: TERMINATED
Conditions: Anaplastic Astrocytoma|Anaplastic Oligodendroglioma|Anaplastic Oligoastrocytoma|Glioblastoma|Gliosarcoma
Interventions: DIETARY_SUPPLEMENT: ascorbic acid|DRUG: temozolomide|OTHER: quality-of-life assessment|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Esocheck in Eosinophilic Esophagitis
Status: COMPLETED
Conditions: Eosinophilic Esophagitis|Diagnoses Disease
Interventions: DEVICE: EsoCheck
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Neoadjuvant Chemoradiotherapy With or Without Gefitinib in Treating Patients With Stage IIIA or Stage IIIB Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: docetaxel|DRUG: gefitinib|DRUG: gemcitabine hydrochloride|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EUCROSS: European Trial on Crizotinib in ROS1 Translocated Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer|Adenocarcinoma|NSCLC
Interventions: DRUG: Crizotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Towards Individualized Deep Brain Stimulation Treatment of Chronic Neuropathic Pain
Status: TERMINATED
Conditions: Neuralgia
Interventions: PROCEDURE: Deep brain stimulation|DEVICE: Cervel Neurotech, Multi-coil TMS|DRUG: 11C-Carfentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Search Strategy for Identifying Urgent Conditions on the Chest X-ray
Status: UNKNOWN
Conditions: Using Expert Visual Search Strategy to Train Students to Read the Chest X-ray
Interventions: OTHER: training in visual search strategy|OTHER: access to a library of chest x-rays without search strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose:
Clinical trial: Mindfulness Approach for Reducing Anxiety and Gloom in Ocular Inflammatory Diseases
Status: RECRUITING
Conditions: Non-infectious Uveitis
Interventions: OTHER: Calm Health - smartphone application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate Efficacy, Safety, Pharmacokinetics, And Pharmacodynamics Of Satralizumab In Patients With Generalized Myasthenia Gravis
Status: ACTIVE_NOT_RECRUITING
Conditions: Generalized Myasthenia Gravis
Interventions: DRUG: Satralizumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Technegas and Xenon-133 Planar Lung Imaging in Subjects Referred for Ventilation Scintigraphy
Status: TERMINATED
Conditions: Lung Structure Determination
Interventions: DRUG: Xe-133|DRUG: Technegas
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety, Tolerability and Pharmacokinetic Investigation of GSK3882347 in Healthy Participants.
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: DRUG: GSK3882347|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quantification of Outcome Measures for Mind-body Interventions
Status: COMPLETED
Conditions: Stress, Psychological|Stress, Physiological
Interventions: BEHAVIORAL: Stress Management Group 1|BEHAVIORAL: Stress Management Group 2|BEHAVIORAL: Stress Management Group 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Effects of Oxytocin and Vasopressin on Moral Decision Making
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxytocin|DRUG: Vasopressin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate Combining Metformin With Muraglitazar or Pioglitazone in Type 2 Diabetics
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Muraglitazar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Initial Performance of a Daily Disposable Contact Lens Featuring Molded Marks
Status: COMPLETED
Conditions: Refractive Error
Interventions: DEVICE: Delefilcon A Multifocal Contact Lenses with Molded Mark|DEVICE: Delefilcon A Multifocal Contact Lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evidence-informed Trial of Lifestyle Interventions to Improve Glycemic Parameters and Reduce Gestational Diabetes in High-risk Pregnant Individuals
Status: NOT_YET_RECRUITING
Conditions: Gestational Diabetes|Pregnancy Complications
Interventions: BEHAVIORAL: GDM Prevention Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prevention of Skin Damage in the Patient in Prone Position: Development of Education Interventions Based on a Training Needs Assessment Study.
Status: COMPLETED
Conditions: Pressure Ulcer|Skin Lesion|Acute Respiratory Distress Syndrome
Interventions: OTHER: Interviews for the needs analysis. No intervention.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Sofosbuvir and Ribavirin in Adults With Recurrent Chronic Hepatitis C Virus (HCV) Post Liver Transplant
Status: COMPLETED
Conditions: Recurrent Chronic Hepatitis C Virus|Post Liver Transplant
Interventions: DRUG: Sofosbuvir|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing Virologic Success and Metabolic Changes in Patients Switching From a TDF to TAF Containing Antiretroviral Therapy Regimen
Status: COMPLETED
Conditions: HIV-1-infection|Metabolic Syndrome|Cardiovascular Diseases|Weight Gain|Renal Function Abnormal|Hyperglycemia
Interventions: DRUG: Tenofovir Alafenamide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Negative Pressure Wound Therapy After Cesarean Delivery
Status: COMPLETED
Conditions: Major Puerperal Infection, Postpartum|Wound Complications|Wound Seroma|Caesarean Section Wound Separation|Wound Infection
Interventions: DEVICE: Prevena negative pressure wound system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Self-management Nursing Intervention for Women With Rheumatoid Arthritis
Status: RECRUITING
Conditions: Arthritis, Rheumatoid
Interventions: BEHAVIORAL: Chronic Disease Self Management Program|BEHAVIORAL: Conventional Care Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate Platelet Rich Plasma to Treat Vulvar Lichen Sclerosus
Status: RECRUITING
Conditions: Vulvar Lichen Sclerosus
Interventions: BIOLOGICAL: Autologous Platelet-Rich Plasma (PRP)|OTHER: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Lidocaine and Magnesium Sulphate on the Attenuation of the Hemodynamic Response to Tracheal Intubation
Status: COMPLETED
Conditions: Intubation Complication|Cardiovascular Morbidity
Interventions: DRUG: Lidocaine|DRUG: Magnesium Sulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: PaThERAS: ERAS Protocols in Thyroid & Parathyroid Surgery
Status: RECRUITING
Conditions: Thyroid Diseases|Parathyroid Diseases|ERAS
Interventions: OTHER: Enhanced recovery protocols|OTHER: Conventional Protocols
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence Of Significant Endoscopic and Histopathologic Findings in Patients Presenting With Unexplained Iron Deficiency Anemia
Status: RECRUITING
Conditions: Gastrointestinal Diseases
Interventions: DEVICE: endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Tirzepatide (LY3298176) Versus Insulin Degludec in Participants With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Tirzepatide|DRUG: Insulin Degludec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Need-based Nutritional Intervention in Nursing Home Residents
Status: COMPLETED
Conditions: Malnutrition
Interventions: DIETARY_SUPPLEMENT: Nutritional supplement|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Immunogenicity of Zoster Vaccine Live (ZOSTAVAX™) in Healthy Adults in India (V211-025)
Status: COMPLETED
Conditions: Herpes Zoster|Shingles
Interventions: BIOLOGICAL: Zoster Vaccine Live
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection
Status: COMPLETED
Conditions: Enterocolitis Clostridium Difficile Recurrent
Interventions: BIOLOGICAL: RBX2660 (microbiota suspension)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Human Interferon α1b Inhalation Solution Against Respiratory Syncytial Virus in Children With Lower Respiratory Tract Infections
Status: RECRUITING
Conditions: Respiratory Syncytial Virus Infections
Interventions: DRUG: Human interferon α1b Inhalation Solution|DRUG: Inhalation Solution Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Detecting Drugs of Abuse Via Exhaled Breath Samples Using Differential Mobility Spectrometry
Status: RECRUITING
Conditions: Opiate Abuse|Marijuana Abuse
Interventions: DRUG: Marihuana|DEVICE: BID2 Instrument - breathalyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy, Safety and Tolerability of AZD9977 and Dapagliflozin in Participants With Heart Failure and Chronic Kidney Disease
Status: COMPLETED
Conditions: Heart Failure|Chronic Kidney Disease
Interventions: DRUG: AZD9977|DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Azithromycin, With or Without Loperamide, to Treat Travelers' Diarrhea
Status: COMPLETED
Conditions: Diarrhea
Interventions: DRUG: Azithromycin 500 mg|DRUG: Azithromycin 1000 mg|DRUG: Loperamide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of PC945
Status: COMPLETED
Conditions: Aspergillosis
Interventions: DRUG: PC945 - single doses|DRUG: Placebo - single doses|DRUG: PC945 - repeat doses|DRUG: Placebo - repeat doses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Incorporating an Exergame Activity Application in a Treatment Regimen for Overweight Children
Status: COMPLETED
Conditions: Body Mass Index|Blood; Sugar, High|Lipid Disorder|Body Image
Interventions: BEHAVIORAL: Control|BEHAVIORAL: Exergame activity_EXG|OTHER: Application activity
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Antibacterial Effect and Clinical Performance of Chitosan Modified Glass Ionomer
Status: COMPLETED
Conditions: Reversible Pulpitis|Pulpitis|Caries,Dental|Caries Class I|Caries; Dentin|Caries
Interventions: DRUG: Glass Ionomer|DRUG: Chitosan Low Molecular Weight (20-200 Mpa.S)|DRUG: Chlorhexidine Diacetate|DRUG: Titanium Dioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SUrveillance of PREMalignant Stomach - Individualized Endoscopic Follow-up
Status: RECRUITING
Conditions: Atrophic Gastritis|Intestinal Metaplasia|Gastric Dysplasia|Gastric Cancer
Interventions: DIAGNOSTIC_TEST: Upper gastrointestinal endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Single Ascending Dose Clinical Trial to Find the Maximum Tolerable Dose of HL237 in Healthy Male Subject
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: HL237|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Blood Flow Restriction Training in Rehabilitation Patients
Status: TERMINATED
Conditions: Anterior Cruciate Ligament Reconstruction|Volumetric Muscle Loss|Chronic Thigh Muscle Weakness|Knee Arthroscopy
Interventions: OTHER: Blood Flow Restriction (BFR) Training|OTHER: Standard ACSM-guided strength training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Avutometinib (VS-6766) v. Avutometinib (VS-6766) + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer With and Without a KRAS Mutation
Status: ACTIVE_NOT_RECRUITING
Conditions: Low Grade Ovarian Serous Adenocarcinoma|Ovarian Cancer
Interventions: DRUG: avutometinib (VS-6766)|DRUG: avutometinib (VS-6766) and defactinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Azithromycin Ophthalmic Solution, 1% Versus Placebo in Subjects With Blepharitis During a Two-Week Treatment Period
Status: COMPLETED
Conditions: Blepharitis
Interventions: DRUG: Azithromycin ophthalmic solution, 1%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single-Center Trial of Intravitreous Injections of Macugen (Pegaptanib Sodium) Given at Least 7 Days Before Vitrectomy Secondary To Tractional Retinal Detachment in Proliferative Diabetic Retinopathy
Status: COMPLETED
Conditions: PDR
Interventions: DRUG: Macugen (Pegaptanib Sodium)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SHR-1701 in Patients With Recurrent/Metastatic Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: SHR-1701|DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Albumin Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Trial of Sirolimus in IBM
Status: RECRUITING
Conditions: Inclusion Body Myositis
Interventions: DRUG: Sirolimus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fruit and Vegetable Products Enriched With Fibre From Potato Starch With Prebiotic Properties for Children and Youth
Status: UNKNOWN
Conditions: Overweight and Obesity|Child Obesity|Hypertension|NAFLD
Interventions: DIETARY_SUPPLEMENT: Vegetable and fruit mousse enriched with a fiber preparation from potato starch with prebiotic properties|DIETARY_SUPPLEMENT: Vegetable and fruit mousse|BEHAVIORAL: Dietary and physical activity counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccinal Effect of HBsAg Monoclonal Ab VIR-3434 in Chronic Hepatitis B Infection [VISION]
Status: RECRUITING
Conditions: Hepatitis B, Chronic
Interventions: DRUG: VIR-3434
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Doxorubicin Hydrochloride, Cyclophosphamide, and Pacltaxel With or Without Trastuzumab in Treating Women With HER2-Positive Node-Positive or High-Risk Node-Negative Breast Cancer
Status: COMPLETED
Conditions: Breast Adenocarcinoma|HER2 Positive Breast Carcinoma|Stage IA Breast Cancer AJCC v7|Stage IB Breast Cancer AJCC v7|Stage IIA Breast Cancer AJCC v6 and v7|Stage IIB Breast Cancer AJCC v6 and v7|Stage IIIA Breast Cancer AJCC v7
Interventions: DRUG: Aromatase Inhibition Therapy|DRUG: Cyclophosphamide|DRUG: Doxorubicin Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel|DRUG: Tamoxifen Citrate|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Berberine on the Secretion of Incretin
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Berberine Chloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE