pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: REtreatment With VEnetoclax and Acalabrutinib After Venetoclax Limited Duration (REVEAL)
Status: RECRUITING
Conditions: CLL/SLL
Interventions: DRUG: Venetoclax/Acalabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Using Botulinum Toxin Type A as Headache Prophylaxis for Migraine Patients With Frequent Headaches
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: BIOLOGICAL: Botulinum Toxin Type A|OTHER: placebo (saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NuvaRing vs. Oral Contraceptive Pills (OCP) for In-Vitro Fertilization (IVF) Pre-treatment
Status: TERMINATED
Conditions: Infertility|In-vitro Fertilization
Interventions: DRUG: NuvaRing|DRUG: marvelon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Periodontal Granulation Tissue Preservation in Surgical Periodontitis Treatment
Status: RECRUITING
Conditions: Periodontal Pocket|Periodontal Diseases|Periodontal Bone Loss
Interventions: PROCEDURE: periodontal surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Intrathecal Morphine Affect Outcomes in Spine Deformity Surgery
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: DRUG: Intrathecal Morphine Injection|DRUG: Pain Relieving
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: i-TREAT: An Internet-based Treatment for Eating Disorders
Status: NOT_YET_RECRUITING
Conditions: Other Specified Feeding or Eating Disorder|Eating Disorder Nos
Interventions: BEHAVIORAL: i-TREAT|OTHER: Waitlist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Safety And Immunogenicity Of Meningococcal B Rlp2086 Vaccine In Adolescents
Status: COMPLETED
Conditions: Meningitis, Meningococcal
Interventions: BIOLOGICAL: meningococcal B rLP2086 vaccine.|BIOLOGICAL: meningococcal B rLP2086 vaccine.|BIOLOGICAL: meningococcal B rLP2086 vaccine.|OTHER: normal saline (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of the BrainPort™ Balance Device to Improve Balance in Bilateral Vestibular Hypofunction
Status: TERMINATED
Conditions: Vestibular Disease
Interventions: DEVICE: Electrotactile sensory substitution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Assess the Safety and Efficacy of Oral PTH (1-34) in the Treatment of Hypoparathyroidism
Status: COMPLETED
Conditions: Hypoparathyroidism
Interventions: DRUG: EnteraBio's Oral Parathyroid Hormone (1-34)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Replication of the SEPRA Diabetes Trial in Healthcare Claims Data
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: New use of semaglutide injection|DRUG: New initiation of "standard of care" (SGL2i, 2nd generation SU, DPP-4i and GLP-1 RA except for semaglutide inj or oral)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase l/ll Study of AMN107 in Adult Patients With Glivec-intolerant CML or Relapsed-refractory Ph+ALL
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia|Acute Lymphoblastic Leukemia (Philadelphia Chromosome Positive)
Interventions: DRUG: Nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Efficacy of A6 in Patients With Chronic Lymphocytic Leukemia (CLL)
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|CLL|SLL
Interventions: DRUG: A6
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Patupilone in Men (≥18 Years) With Metastatic Hormone Refractory Prostate Cancer
Status: COMPLETED
Conditions: Metastatic Hormone Refractory Prostate Cancer
Interventions: DRUG: Patupilone|DRUG: prednisone|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Randomized, Double-Blind Placebo Controlled, Multi-regional Trial to Evaluate the Efficacy and Safety of GT0918 for the Treatment of Mild to Moderate COVID-19 Male Patients
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: GT0918 tablets or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetics and Safety Study in Subjects With Renal Impairment
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: TR-701 FA single infusion|DRUG: TR-701 FA|DRUG: TR-701 FA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Immunosuppressive Treatment in iMN
Status: RECRUITING
Conditions: Idiopathic Membranous Nephropathy
Interventions: DRUG: Prednisone|DRUG: Cyclophosphamide|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Neuromuscular Exercise Program for Patients With Anterior Shoulder Instability
Status: COMPLETED
Conditions: Shoulder Dislocation|Musculoskeletal Diseases
Interventions: OTHER: Neuromuscular exercise program|OTHER: Standard home exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Consistencies in Responses to Sodium Bicarbonate?
Status: COMPLETED
Conditions: Sports Nutritional Physiological Phenomena
Interventions: DIETARY_SUPPLEMENT: sodium bicarbonate|DIETARY_SUPPLEMENT: calcium carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Age and Gender Effects on the Pharmacokinetics of BAY85-3934
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: BAY85-3934|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hot Flashes and Omega 3
Status: COMPLETED
Conditions: Hot Flashes|Fatty Acids|Menopause
Interventions: DIETARY_SUPPLEMENT: omega-3 fatty acids|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brain Computer Interface (BCI) Integrated Wearable Hand Robotic Glove System for Upper Limb Stroke Rehabilitation
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: DEVICE: Brain Computer Interface integrated HandyRehab platform (BCI-HR)|DEVICE: HandyRehab (HR)|OTHER: Standard Treatment of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Radioimmunoguided Intensity Modulated Radiotherapy (IMRT) for Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasm
Interventions: RADIATION: radioimmuniguided intenstiy modulated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Muscle Training's Respiratory Outcomes and Voice Enhancement in Parkinson's Disease
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease|Pulmonary Disease|Voice Disorders
Interventions: BEHAVIORAL: respiratory muscle training|BEHAVIORAL: Expiratory Muscle Training|BEHAVIORAL: Placebo-Controlled Expiratory Muscle Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study for Patients With Rheumatoid Arthritis on Methotrexate (MTX) With an Inadequate Response to TNFα Inhibitor Therapy
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: BIOLOGICAL: LY2127399|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Kinesio Taping on Trapezius Trigger Points After Integrated Neuromuscular Inhibition Technique (INIT)
Status: COMPLETED
Conditions: Trigger Points
Interventions: OTHER: Kinesiotaping|OTHER: Integrated Neuromuscular Inhibition Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Doses of Dexmedetomidine With Bupivacaine in Caudal Block for Duration of Analgesia in Paediatric Infraumblical Surgeries.
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: Bupivacaine Hydrochloride|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
Status: RECRUITING
Conditions: Hematologic Disorder|Bleeding Disorder|Connective Tissue Disorder|Hemophilia|Thrombosis|Von Willebrand Diseases|Thrombophilia|Rare Bleeding Disorder|Platelet Disorder|Factor IX Deficiency|Factor VIII Deficiency|Thalassemia|Sickle Cell Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Home OCT-Guided Treatment Versus Treat and Extend for the Management of Neovascular AMD
Status: RECRUITING
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: Intravitreal injections of 6 mg faricimab on a Treat and Extend schedule|DEVICE: Intravitreal injections of 6 mg faricimab on a home optical coherence tomography-guided treatment schedule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation Outcome Assessments of the Emergency Department Delirium Screening and Detection Program
Status: ACTIVE_NOT_RECRUITING
Conditions: Delirium
Interventions: BEHAVIORAL: Emergency Department Delirium Screening and Detection Program (ED-DDP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Autologous CD30.CAR-T in Combination With Nivolumab in cHL Patients After Failure of Frontline Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Classical Hodgkin Lymphoma|Hodgkin Disease Refractory|Hodgkin Disease Recurrent
Interventions: DRUG: Nivolumab|DRUG: Autologous CD30.CAR-T|DRUG: Fludarabine|DRUG: Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cohort Field Study to Assess the Safety and Efficacy of the PrePex Device for Non-Surgical Circumcision When Performed by Nurses
Status: COMPLETED
Conditions: Male Circumcision|HIV Prevention
Interventions: DEVICE: PrePex™ device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics, Pharmacodynamics and Safety of Basis in Acute Kidney Injury Study
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: DIETARY_SUPPLEMENT: Basis|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Reduced Doses of Antimony Plus Ranulocyte Monocyte Colony Stimulating Factor (GM-CSF) for Cutaneous Leishmaniasis
Status: COMPLETED
Conditions: Cutaneous Leishmaniasis
Interventions: DRUG: GMCSF plus Antimony reduced dose|DRUG: Meglumine antimoniate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: How Does Patients' Overall Assessment of Their Health Vary Across and Within Different Disease Groups?
Status: UNKNOWN
Conditions: Hip Disease|Heart Failure|Psoriasis|Fractures, Bone|Bipolar Disorder|Respiratory Failure|Knee Disease|Knee Injuries|Ankle Disease|Spinal Disease|Rheumatic Diseases|Osteoarthritis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Genetics of the Combined Pulmonary Fibrosis and Emphysema Syndrome
Status: UNKNOWN
Conditions: Combined Pulmonary Fibrosis and Emphysema Syndrome|Pulmonary Fibrosis|Emphysema|Healthy Subjects
Interventions: GENETIC: Genetic analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Alisertib in Chemotherapy-pretreated Urothelial Cancer
Status: COMPLETED
Conditions: Bladder Cancer|Transitional Cell Carcinoma
Interventions: DRUG: Alisertib|DRUG: Paclitaxel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Dexmedetomidine and Ketamine Infusion on the Inflammatory Response in Liver Resection
Status: NOT_YET_RECRUITING
Conditions: Inflammation|Analgesia
Interventions: PROCEDURE: Control Group|PROCEDURE: Ketamine Group|PROCEDURE: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Number of Passes Required for Diagnostic Cell Block During EUS-FNA of Solid Pancreatic Mass Lesions
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: PROCEDURE: EUS FNA with 2 passes|PROCEDURE: EUS FNA with 4 passes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Randomized Trial :Hemorrhoidal Pedicle Ligation vs Laser vs Open Hemorrhoidectomy
Status: UNKNOWN
Conditions: Hemorrhoids Second Degree|Hemorrhoids Third Degree
Interventions: PROCEDURE: Haemorrhoidectomy operations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Flipped Classroom Approach in Continuous Ambulatory Peritoneal Dialysis Training
Status: NOT_YET_RECRUITING
Conditions: Chronic Kidney Disease
Interventions: BEHAVIORAL: Audio-visual assisted Flipped Classroom (FC) CAPD Training Programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Transcatheter Treatment of Tricuspid Valve Regurgitation
Status: NOT_YET_RECRUITING
Conditions: Symptomatic Severe Tricuspid Regurgitation
Interventions: DEVICE: TriFlo Tricuspid Flow Optimizer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Live Birth After Fresh Embryo Transfer Vs Frozen-thawed Embryo Transfer in Women With Polycystic Ovary Syndrome
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome|Infertility
Interventions: OTHER: fresh embryo transfer|OTHER: frozen-thawed embryo transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventive IVIG Therapy for Congenital Heart Block
Status: COMPLETED
Conditions: Congenital Heart Block|Neonatal Lupus|Autoantibody-associated Heart Block
Interventions: DRUG: intravenous immune globulin (IVIG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dose De-escalation and Sentinel LN Mapping Driven Radiotherapy of Contralateral Neck in Ipsilateral Node Positive HNSCC
Status: RECRUITING
Conditions: Squamous Cell Carcinoma of Head and Neck
Interventions: RADIATION: Dose de-escalation and / or Volume de-escalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weight Management for the Remission of Type 2 Diabetes Using a Proprietary Meal Replacement System- Diabetes Remission Study (DRS)
Status: TERMINATED
Conditions: Obesity|Diabetes Mellitus, Type 2
Interventions: DIETARY_SUPPLEMENT: Meal replacement system|BEHAVIORAL: Intensive lifestyle Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Whether Survodutide (BI 456906) Helps People Living With Overweight or Obesity Who Also Have Diabetes to Lose Weight
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Diabetes Mellitus, Type 2
Interventions: DRUG: Survodutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irrigated Ablation System Evaluation for Atrial Fibrillation (AF)
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: SJM Irrigated Cardiac Ablation System|DEVICE: FDA approved Open Irrigated RF Ablation System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Correlation Between Micro Vascular Complications and Severity of Coronary Artery Disease in Type 2 DM
Status: COMPLETED
Conditions: Patients With Type 2 DM Who Underwent Coronary Angiography Due to Coronary Artery Disease and Presence of Microvascular Complications in Same Patients
Interventions: DIAGNOSTIC_TEST: albumin creatinine ratio -EGFR-fundus examination- coronary angiography.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comparison of Nefopam-propacetamol Combination and Propacetamol for Postoperative Quality of Recovery After Laparoscopic Nephrectomy
Status: COMPLETED
Conditions: Renal Tumor
Interventions: DRUG: nefopam-propacetamol combination|DRUG: propacetamol alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Targeted Radiotherapy in Neuroendocrine Tumors
Status: COMPLETED
Conditions: Neuroendocrine Tumors
Interventions: OTHER: 131-I MIBG and 111-In pentetreotide|OTHER: 131-I MIBG and In-111 DOTATATE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Targeted Therapy in Patients With Resectable EGFR-mutated Lung Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Lung Cancer|Carcinoma, Squamous Cell
Interventions: DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weekly Subcutaneous Semaglutide as Adjunct to Closed-loop Therapy in Type 1 Diabetes Care
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 1 Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: Outpatient therapy: 11 weeks of drug therapy with usual treatment + 4 weeks of closed-loop therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial
Status: RECRUITING
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: OTHER: Natalizumab, Alemtuzumab, Ocrelizumab, Rituximab, Cladribine, Ofatumumab, Ublituximab-xiiy|OTHER: Glatiramer acetate, Interferons (intramuscular, subcutaneous, pegylated) Teriflunomide, Fumarates (dimethyl, diroximel, monomethyl) Fingolimod, Siponimod, Ozanimod, Ponesimod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Can Insulin Glargine Improve Myocardial Function in Patients With T2D and Coronary Artery Disease (CAD)
Status: UNKNOWN
Conditions: Coronary Artery Disease|Type 2 Diabetes
Interventions: DRUG: insulin glargine|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Impact of Acid-reducing Agents on the Pharmacokinetics (PK) of AMG 510 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: AMG 510|DRUG: Omeprazole|DRUG: Famotidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Calcineurin-inhibitor Reduction With Conversion at 2 Months to Everolimus/Reduced Tacrolimus in Renal Transplant Recipients Following Campath® Induction
Status: COMPLETED
Conditions: Renal Transplant
Interventions: DRUG: Arm 1 Everolimus/Reduced dose tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Point-of-care Produced CAR T-cell With Commercial CAR T-cells in Patients With R/R LBCL
Status: RECRUITING
Conditions: NHL|DLBCL - Diffuse Large B Cell Lymphoma
Interventions: DRUG: ARI-0001|DRUG: Axi-cel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regional Anaesthesia for Painful Injuries After Disasters
Status: WITHDRAWN
Conditions: Lower Limb Injuries|Fracture
Interventions: DRUG: Bupivacaine (femoral nerve block)|DRUG: Morphine|DEVICE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Novel Method for Capturing the Visual Evoked Potential During Spine Surgery Under Total Intravenous Anesthesia
Status: COMPLETED
Conditions: Evoked Potentials, Visual
Interventions: DEVICE: SightSaver Visual Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Energy Drinks Consumption on Acute Physiological and Psychological Responses of Israeli Arab Adolescents
Status: UNKNOWN
Conditions: Energy Drinks
Interventions: OTHER: Drink A + SC|OTHER: Drink B + SC|OTHER: Drink C + SC|OTHER: Drink A + CC|OTHER: Drink B + CC|OTHER: Drink C + CC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial of Metformin to Decrease Glucocorticoids Side Effects in Patients With Autoimmune Uveitis
Status: UNKNOWN
Conditions: Uveitis|Metformin|Glucocorticoid
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Simmitinib Plus Irinotecan in Advanced Esophageal Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Advanced Esophageal Squamous Cell Carcinoma
Interventions: DRUG: simmitinib plus irinotecan liposome|DRUG: irinotecan liposome|DRUG: irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kanagawa Combination Anti-hypertensive Therapy (K-CAT)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Losartan/amlodipine or losartan/hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial for the Prevention of SARS-CoV-2 Infection (COVID-19) in Healthcare Personnel
Status: COMPLETED
Conditions: Coronavirus Infection
Interventions: DRUG: Emtricitabine/tenofovir disoproxil|DRUG: Hydroxychloroquine|DRUG: Placebo: Emtricitabine/tenofovir disoproxil Placebo|DRUG: Placebo: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: An Initial Evaluation of the Carillon Mitral Contour System for Treatment of Atrial Function Mitral Regurgitation
Status: TERMINATED
Conditions: Functional Mitral Regurgitation|Atrial Fibrillation|Atrial Functional Mitral Regurgitation
Interventions: DEVICE: Carillon Mitral Contour System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Biochemical Response to Alternative Proteins
Status: RECRUITING
Conditions: Postprandial Hyperglycemia|Overweight and Obesity|Type2diabetes
Interventions: DIETARY_SUPPLEMENT: High fiber and protein meal|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: ARUA-ALZ - Connecting Audio and Radio SensingmSystems to Improve Care at Home for ADRD
Status: COMPLETED
Conditions: Alzheimer Disease|Caregiver Burden
Interventions: DEVICE: AURA_ALZ
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Bioequivalence of Generic Imiquimod Cream, 5% When Compared to Aldara™ (Imiquimod) Cream, 5% in the Treatment of Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratoses
Interventions: DRUG: imiquimod|DRUG: Aldara™|DRUG: Vehicle Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ph II Bev + Either Temozolomide/Etoposide for GBM Pts Who Have Failed Bev + Irinotecan
Status: COMPLETED
Conditions: Glioblastoma|Gliosarcoma
Interventions: DRUG: Temo + Avastin|DRUG: VP-16 + Avastin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MUCOviscidose EXacerbation Outils Connectés Education Thérapeutique
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DEVICE: Connected Devices for 3 months|BEHAVIORAL: Educationnal Intervention|DEVICE: Connected Devices for 12 months|OTHER: Interviews|BEHAVIORAL: Refusal Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Kinesio-taping Technique on Oral Feeding in Late Preterm Infants
Status: COMPLETED
Conditions: Swallow|Preterm Infant|Newborn|Kinesiotaping|Sucking
Interventions: DEVICE: Kinesiotaping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Changes During Operative Hysteroscopy
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Normal Saline 0.9% Infusion Solution Bag|DRUG: 1.5% Glycine only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Effectiveness of Evinacumab for the Treatment of Homozygous Familial Hypercholesterolemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Homozygous Familial Hypercholesterolemia
Interventions: DRUG: Evinacumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Randomized Placebo-Controlled, Double-Blind Study to Evaluate Safety and Immunogenicity of AERAS-404 Administered as Different Amounts of Antigen and Adjuvant Combinations in HIV-Negative BCG-Vaccinated Adults Without Evidence of Tuberculosis Infection
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: AERAS-404|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Evaluating the Efficacy and Safety of HSK21542 Injection for Analgesia in Subjects Undergoing Colonoscopy
Status: COMPLETED
Conditions: Analgesia
Interventions: DRUG: Stage I: HSK21542 0.5 μg/kg|DRUG: Stage I: HSK21542 1 μg/kg|DRUG: HSK21542 0.5 μg/kg|DRUG: HSK21542 1 μg/kg|DRUG: HSK21542 2 μg/kg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-market Verification of Portable X Ray Machines for Lung Diseases and Orthopedic Limb Lesions
Status: COMPLETED
Conditions: X-rays; Effects|Chest--Diseases|Orthopedic Disorder
Interventions: DEVICE: ERI CVX-air portable X-ray system|DEVICE: Samsung GM85 (K180543) or MobileDaRt Evolution (K080701)|DEVICE: Samsung GC85A (K160997) or Fujifilm FDR Smart X (K212956)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Active Treatment Study of SRK-015 in Patients With Type 2 or Type 3 Spinal Muscular Atrophy
Status: COMPLETED
Conditions: Spinal Muscular Atrophy|Spinal Muscular Atrophy Type 3|Spinal Muscular Atrophy Type 2|SMA|Neuromuscular Diseases|Muscular Atrophy|Atrophy|Muscular Atrophy, Spinal|Neuromuscular Manifestations
Interventions: BIOLOGICAL: SRK-015
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The OLYMPUS Study - Optimized DeLivery of Mitomycin for Primary UTUC Study
Status: COMPLETED
Conditions: Carcinoma, Transitional Cell|Transitional Cell Carcinoma of Renal Pelvis
Interventions: DRUG: UGN-101 instillations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ovarian Hyperstimulation Syndrome Using Calcium Infusion
Status: UNKNOWN
Conditions: Ovarian Hyperstimulation Syndrome
Interventions: DRUG: Calcium intravenous infsuion|DRUG: 0.9 % saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study to Investigate the Safety and Efficacy of PA21, a Phosphate Binder, in Dialysis Patients
Status: COMPLETED
Conditions: Chronic Kidney Disease Requiring Chronic Dialysis
Interventions: DRUG: PA21 (2.5 g tablet containing 500 mg iron)|DRUG: Sevelamer carbonate|DRUG: PA21-1 (1.25 g tablet containing 250 mg iron)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Protein Weight Loss Diet, High Sensitivity C-Reactive Protein and Cardiovascular Risks Among Obese Women
Status: COMPLETED
Conditions: Body Mass Index Quantitative Trait Locus 8 Disorder|Tangier Disease
Interventions: OTHER: nutrition intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Docetaxel With or Without Oblimersen in Treating Patients With Hormone-Refractory Adenocarcinoma (Cancer) of the Prostate
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: oblimersen sodium|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effects of Cognitive Rehabilitation on Motor Performance, Balance and Fear of Falling in Stroke Patients
Status: UNKNOWN
Conditions: Stroke|Cognition Disorder|Fear Anxiety
Interventions: OTHER: Cognitive Rehabilitation|OTHER: Conventional Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Altering Default Mode Network Activity With Transcranial Focused Ultrasound to Reduce Depressive Symptoms
Status: ACTIVE_NOT_RECRUITING
Conditions: Depressive Disorder, Major|Depression
Interventions: DEVICE: Non-Invasive Transcranial Focused Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Fluorine-18 3'-Deoxy-3'-Fluorothymidine (F-18-FLT) in Invasive Breast Cancer
Status: COMPLETED
Conditions: Stage IIB Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: PROCEDURE: CT|DRUG: 18F-FLT|PROCEDURE: PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Oral AMXT 1501 Dicaprate in Combination With DFMO
Status: COMPLETED
Conditions: Cancer|Solid Tumor|Solid Carcinoma|Advanced Cancer
Interventions: DRUG: AMXT1501|DRUG: DFMO
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Program for Alleviating and Resolving Trauma and Stress 2
Status: ACTIVE_NOT_RECRUITING
Conditions: Post-traumatic Stress Disorder
Interventions: BEHAVIORAL: PARTS Program|BEHAVIORAL: NBSR-T Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bortezomib Followed by the Addition of Doxorubicin at Disease Progression in Treating Patients With Locally Advanced, Recurrent, or Metastatic Adenoid Cystic Carcinoma (Cancer) of the Head and Neck
Status: COMPLETED
Conditions: Recurrent Adenoid Cystic Carcinoma of the Oral Cavity|Recurrent Salivary Gland Cancer|Salivary Gland Adenoid Cystic Carcinoma|Stage III Adenoid Cystic Carcinoma of the Oral Cavity|Stage III Salivary Gland Cancer|Stage IV Adenoid Cystic Carcinoma of the Oral Cavity|Stage IV Salivary Gland Cancer
Interventions: DRUG: bortezomib|DRUG: doxorubicin hydrochloride|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fentanyl and Propofol for Tracheal Intubation During Sevoflurane Induction Without Muscle Relaxants in Children
Status: COMPLETED
Conditions: Anesthesia Intubation Complication
Interventions: DRUG: propofol /Fentanyl|DRUG: Fentanyl / propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Autoimmune Diabetes Accelerator Prevention Trial
Status: WITHDRAWN
Conditions: Prediabetic State
Interventions: DRUG: Metformin Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study on Home Obstructive Respiratory Exacerbations
Status: NOT_YET_RECRUITING
Conditions: COPD Exacerbation|COPD (Chronic Obstructive Pulmonary Disease) With Acute Lower Respiratory Infection|COPD Exacerbation Acute|COPD
Interventions: DEVICE: RESP Biosensor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use of a GLP-1R Agonist to Treat Opioid Use Disorder
Status: COMPLETED
Conditions: Opiate Substitution Treatment|Opioid-Related Disorders
Interventions: DRUG: Liraglutide Pen Injector|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BioTechCOACH-ForALL: Development of Mental and Physical Exercise Systems, Clinical Recording, Supervisory Analytical Large-scale Data and Virtual Guidance of Vulnerable Population Groups
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: BiotechCoachForAll
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety of NGOIS Compared to BSS Plus in Pediatric Patients
Status: COMPLETED
Conditions: Cataract
Interventions: DRUG: Next Generation Ophthalmic Irrigating Solution (NGOIS)|DRUG: BSS Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Patient-centred Deprescribing of Psychotropic, Sedative and Anticholinergic Medication in Elderly Patients With Polypharmacy
Status: RECRUITING
Conditions: Deprescriptions|Antidepressive Agents|Antipsychotic Agents|Analgesics, Opioid|Hypnotics and Sedatives|Cholinergic Antagonists
Interventions: BEHAVIORAL: PARTNER intervention|BEHAVIORAL: Control intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study Evaluating Safety and Efficacy of BIOD 531 Compared to Humalog® Mix 75/25 in Subjects With Type 2 Diabetes
Status: SUSPENDED
Conditions: Diabetes Mellitus
Interventions: DRUG: BIOD-531|DRUG: Humalog® Mix 75/25
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Neural Flossing and PNF on Lumbar Radiculopathy
Status: RECRUITING
Conditions: Lumbar Radiculopathy
Interventions: OTHER: neural flossing with proprioceptive neuromuscular facilitation|OTHER: Neural flossing without proprioceptive neuromuscular facilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Three Schedules of CUE-101 Administered Before Surgery or Definitive Chemoradiation Therapy in HLA-A*0201 Positive Patients With Locally Advanced, HPV16-Positive Oropharyngeal Squamous-Cell Carcinoma
Status: RECRUITING
Conditions: Oropharyngeal Squamous Cell Carcinoma
Interventions: DRUG: CUE-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety, and Sperm and Gonadotropin Suppression of a Contraceptive Gel in Normal Men
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Testosterone|DRUG: Nestorone®|DRUG: Nestorone®|DRUG: Nestorone®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: CCI-779 in Treating Patients With Extensive-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Extensive Stage Small Cell Lung Cancer
Interventions: DRUG: temsirolimus|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Subcutaneous Continuous Administration of Levodopa/Carbidopa Solution (ND0612) in Healthy Volunteers
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: ND0612|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Autologous Stromal Vascular Fractions on Skin Regeneration
Status: UNKNOWN
Conditions: Skin|Aging
Interventions: BIOLOGICAL: stromal vascular fraction|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of ICP in Idiopathic Intracranial Hypertension Using Transocular Ultrasound and Transcranial Doppler
Status: COMPLETED
Conditions: Idiopathic Intracranial Hypertension
Interventions: DIAGNOSTIC_TEST: TOS and TCD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Characterize the Clinical Course of Pregnant Women and Children at High Risk for Early Onset Severe Hemolytic Disease of the Fetus and Newborn
Status: COMPLETED
Conditions: Early Onset Severe Hemolytic Disease of the Fetus and Newborn (EOS-HDFN)|Erythroblastosis, Fetal
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of Antroquinonol in Patients With Hypercholesterolemia and Hyperlipidemia
Status: COMPLETED
Conditions: Hyperlipidemias
Interventions: DRUG: Antroquinonol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Depth of Neuromuscular Block on Surgical Operating Conditions in Gynecologic Laparoscopic Surgery
Status: COMPLETED
Conditions: Neuromuscular Blockade
Interventions: PROCEDURE: Quality of surgical field conditions|DRUG: Deep Neuromuscular Block|DRUG: Moderate Neuromuscular Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: To Brace or Not to Brace for Single Level Lumbar Fusion Pilot
Status: RECRUITING
Conditions: Lumbar Spondylosis|Fusion of Spine
Interventions: DEVICE: Lumbar brace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Immunogenicity of INO-4700 for MERS-CoV in Healthy Volunteers
Status: COMPLETED
Conditions: Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Interventions: DRUG: INO-4700|DRUG: Placebo|DEVICE: CELLECTRA™ 2000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 2 Trial of Pertuzumab and Trastuzumab With Weekly Paclitaxel and Chemotherapy for HER2 Positive Breast Cancer
Status: COMPLETED
Conditions: Her2-Positive Breast Cancer
Interventions: DRUG: Pertuzumab|DRUG: Trastuzumab|DRUG: Paclitaxel|DRUG: 5-fluorouracil|DRUG: Epirubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Maintenance Regorafenib vs Placebo, no Progression Patients After I Line Chemotherapy Metastatic Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: Regorafenib|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-Center Study Evaluating the Efficacy of Wobenzym(R)N in Treating Knee Osteoarthritis
Status: WITHDRAWN
Conditions: Knee Osteoarthritis
Interventions: DIETARY_SUPPLEMENT: Wobenzym® N|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HuMax-CD20 in Active Rheumatoid Arthritis, Phase I/II
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Part A|DRUG: Part B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ESCALATion of Medical Therapy Following Multimodality Plaque Evaluation in High-risk Chronic Coronary Syndromes
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease
Interventions: DRUG: Colchicine 0.5 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of GWP42003 as Adjunctive Therapy in the First Line Treatment of Schizophrenia or Related Psychotic Disorder
Status: COMPLETED
Conditions: Schizophrenia|Schizophrenia-related Psychotic Disorder
Interventions: DRUG: Placebo|DRUG: GWP42003
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bipolar Intervention Study: Cognitive Interpersonal Therapy
Status: COMPLETED
Conditions: Mania|Hypomania|Bipolar Affective Disorder
Interventions: OTHER: Cognitive Interpersonal Therapy|OTHER: Treatment As Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rollover Trial Safety and Tolerability of Combination Tipranavir and Ritonavir Use in HIV 1 Infected Subjects
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Tipranavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-surgical Scars After the Use of CACIPLIQ20
Status: RECRUITING
Conditions: Scars
Interventions: DEVICE: CACIPLIQ20®|DRUG: Placebo (saline solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Relative Bioavailability of Brensocatib Pediatric Oral Solution to Oral Tablets in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Brensocatib Oral Solution|DRUG: Brensocatib Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT