pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Trilaciclib vs Placebo in Patients With Extensive Stage Small Cell Lung Cancer (ES-SCLC) Receiving Topotecan
Status: RECRUITING
Conditions: Extensive-stage Small-cell Lung Cancer
Interventions: DRUG: Trilaciclib|DRUG: Placebo|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acute vs. Delayed Iron: Effect on Red Cell Iron Incorporation in Severe Malaria
Status: COMPLETED
Conditions: Iron Deficiency|Malaria|Nutrition|Global Health
Interventions: DIETARY_SUPPLEMENT: Immediate iron|DIETARY_SUPPLEMENT: Delayed iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oral Administration of Postibiotic by FOS Fermentation From Lactobacillus Paracasei in the Treatment of Irritable Bowel Syndrome.
Status: NOT_YET_RECRUITING
Conditions: IBS - Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: PostbiotiX Slowing 4 g sachets PostbiotiX Slowing is a food supplement based on Fermented FOS from Lactobacillus paracasei CNCM I-5220.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Study Of Entrectinib (Rxdx-101) in Children and Adolescents With Locally Advanced Or Metastatic Solid Or Primary CNS Tumors And/Or Who Have No Satisfactory Treatment Options
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumors|CNS Tumors
Interventions: DRUG: Entrectinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: D-Cycloserine-Enhancer of One-Session Treatment for Phobia of Heights
Status: UNKNOWN
Conditions: Height Phobia
Interventions: BEHAVIORAL: In Vivo Exposure Therapy|BEHAVIORAL: Virtual Reality Exposure Therapy|DRUG: D-Cycloserine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Output Pulmonary Arterial Catheter Compared to FloWave™ 1000
Status: COMPLETED
Conditions: Congestive Heart Failure|Ischemic Cardiomyopathy|Mitral Valve Prolapse|Mitral Regurgitation|Aortic Valve Disease|Tricuspid Regurgitation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Safety, Tolerability, PK/PD, and Metabolism of Single-Dose Singletine(DC407) in Adults
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Singletine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Isolated Hepatic Perfusion With Melphalan in Treating Patients With Unresectable Colorectal Cancer That Has Metastasized to the Liver
Status: COMPLETED
Conditions: Colorectal Cancer|Metastatic Cancer
Interventions: DRUG: isolated perfusion|DRUG: melphalan|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Alternating Current Stimulation (TACS) for Sleep Disturbances in Neurocognitive Disorders Due to Alzheimer's Disease
Status: COMPLETED
Conditions: Brain Stimulation|Alzheimer Disease|tACS|Sleep Disturbance|Aging|Cognitive Impairment, Mild
Interventions: DEVICE: High-definition transcranial current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus
Status: COMPLETED
Conditions: Bacterial Endocarditis|Bacteremia
Interventions: DRUG: daptomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Farletuzumab (MORAb-003) in Combination With Carboplatin and Taxane in Participants With Platinum-sensitive Ovarian Cancer in First Relapse
Status: TERMINATED
Conditions: Ovarian Cancer
Interventions: DRUG: Farletuzumab|DRUG: Carboplatin|DRUG: Taxane|DRUG: Farletuzumab-matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A VI-0521 Study to Evaluate the Long-term Safety and Efficacy in Type 2 Diabetic Adults
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: Phentermine/Topiramate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gene Therapy and Chemotherapy in Treating Patients With Advanced Solid Tumors or Non-Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Brain and Central Nervous System Tumors|Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: sargramostim|BIOLOGICAL: therapeutic autologous lymphocytes|DRUG: O6-benzylguanine|DRUG: carmustine|DRUG: temozolomide|PROCEDURE: in vitro-treated peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COPD Patients Diagnosed With GERD,COPD Exacerbations After Treatment With High Dose PPI
Status: TERMINATED
Conditions: Gastroesophageal Reflux|Chronic Obstructive Pulmonary Disease
Interventions: PROCEDURE: 24 hour pH testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrapleural Gene Transfer for Pleural Mesothelioma
Status: COMPLETED
Conditions: Malignant Pleural Mesothelioma
Interventions: BIOLOGICAL: SCH 721015|BIOLOGICAL: SCH 721015
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Conventional Non-invasive Mechanical Ventilation (NIV) Versus an Automatic Ventilation Mode.
Status: COMPLETED
Conditions: Hypoxemic Respiratory Failure|Hypercapnic Respiratory Failure
Interventions: DEVICE: BIPAP, Intelligent automatic mode defined by assured volume with pressure support|DEVICE: BIPAP, manual tritration.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk Factors for Type 2 Diabetes Mellitus With Cognitive Impairment: a Cohort Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2|Cognitive Dysfunction|Gut Microbiota
Interventions: OTHER: whether the participants had T2DM
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Seprafilm™ for the Prevention of Intraperitoneal Adhesions and Improved Delivery of Therapy in Women Undergoing Staging and Intraperitoneal Chemotherapy for Advanced Ovarian Cancer
Status: TERMINATED
Conditions: Epithelial Ovarian Cancer
Interventions: PROCEDURE: Seprafilm™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of CKDB-501A in Subjects With Post-stroke Upper Limb Spasticity
Status: COMPLETED
Conditions: Post-stroke Upper Limb Spasticity
Interventions: DRUG: CKDB-501A|DRUG: Botox®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Graves' Orbitopathy (Thyroid Eye Disease) to Reduce Proptosis With Teprotumumab Infusions in a Randomized, Placebo-Controlled, Clinical Study
Status: COMPLETED
Conditions: Thyroid Eye Disease|Graves' Orbitopathy
Interventions: BIOLOGICAL: Teprotumumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Assessing Saxagliptin Treatment In Type 2 Diabetic Subjects Who Are Not Controlled With Metformin Alone
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Saxagliptin + Metformin|DRUG: Saxagliptin + Metformin|DRUG: Saxagliptin + Metformin|DRUG: Placebo + Metformin|DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Combination With Low-dose PFas Neoadjuvant Treatment for Locally Advanced HNSCC
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: COMBINATION_PRODUCT: pembrolizumab+cisplatin + 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-In-Human Study To Evaluate Safety, Tolerability, And Pharmacokinetics Following Single Ascending And Multiple Ascending Doses of PF-07304814 In Hospitalized Participants With COVID-19.
Status: COMPLETED
Conditions: Viral Disease
Interventions: DRUG: PF-07304814|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term, Non-interventional, Observational Study Following Treatment With Fate Therapeutics FT500 Cellular Immunotherapy
Status: TERMINATED
Conditions: Advanced Solid Tumor|Lymphoma|Gastric Cancer|Colorectal Cancer|Head and Neck Cancer|Squamous Cell Carcinoma|EGFR Positive Solid Tumor|HER2-positive Breast Cancer|Hepatocellular Carcinoma|Small-cell Lung Cancer|Renal Cell Carcinoma|Pancreas Cancer|Melanoma|NSCLC|Urothelial Carcinoma|Cervical Cancer|Microsatellite Instability|Merkel Cell Carcinoma
Interventions: GENETIC: Allogeneic natural killer (NK) cell
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Atezolizumab and Tiragolumab in Patients With NSCLC or Advanced Solid Tumors Having Had Prior Treatment With a PD-1 Inhibitor
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer|Solid Tumor
Interventions: DRUG: Atezolizumab|OTHER: Chemotherapy (Arm A Only)|DRUG: Tiragolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Assess the Efficacy and Safety of THVD-201 in Patients With OAB
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: THVD-201|DRUG: Placebo(For THVD-201)|DRUG: Detrusitol 2mg tablet|DRUG: Placebo(For Detrusitol 2mg tablet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Dr. Reddy's Laboratories Limited Fexofenadine Hydrochloride 180 mg Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Fexofenadine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of FYU-981 in Hyperuricemia With or Without Gout
Status: COMPLETED
Conditions: Hyperuricemia
Interventions: DRUG: FYU-981|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Healthy Lifestyle Intervention in Patients With Systemic Lupus Erythematosus: The Living Well With Lupus Study
Status: UNKNOWN
Conditions: Systemic Lupus Erythematosus
Interventions: BEHAVIORAL: Living well with Lupus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Open-label Trial to Assess Subject Preference of PARCOPA, Carbidopa/Levodopa Orally Disintegrating Tablets, Compared to Conventional Carbidopa/Levodopa Tablets in Subjects With Stable Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: PARCOPA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Investigate the Effect of Food on the Pharmacokinetic of JLP-1207 in Healthy Male Volunteers
Status: COMPLETED
Conditions: LUTS|Benign Prostatic Hyperplasia|Overactive Bladder
Interventions: DRUG: JLP-1207(Fasted)|DRUG: JLP-1207(Fed)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Inhaled Cannabidiol in Healthy Occasional Cannabis Users
Status: NOT_YET_RECRUITING
Conditions: Cannabis
Interventions: DRUG: Cannabis, placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Simulation RCT of Telemedical Support for Paramedics
Status: COMPLETED
Conditions: Respiratory Failure|Status Epilepticus|Status Asthmaticus|Cardiopulmonary Arrest
Interventions: OTHER: Telemedicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Technology-based Intervention and Positive Psychological Training for Blood Pressure Control in African Americans
Status: COMPLETED
Conditions: Hypertension|Self-management|Technology
Interventions: BEHAVIORAL: Technology-based Component|BEHAVIORAL: TechSupport
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vancomycin in Patients With Unresectable Fibrolamellar Hepatocellular Carcinoma (FLC) Oral
Status: WITHDRAWN
Conditions: Metastatic Hepatocellular Carcinoma|Hepatocellular Carcinoma
Interventions: DRUG: vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of Liraglutide in the Treatment of Type 2 Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: Victoza®.|DRUG: Metformin Hydrochloride|DRUG: TQZ2451
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effectiveness of Sildenafil at Improving Health Outcomes and Exercise Ability in People With Diastolic Heart Failure (The RELAX Study)
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Placebo|DRUG: Sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vortioxetine Intravenous Infusion at Initiation of Oral Treatment With Vortioxetine in Patients With Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Vortioxetine infusion 25 mg|DRUG: Vortioxetine tablets 10 mg/day|DRUG: Placebo infusion|DRUG: Placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of SARS-CoV-2 Antibodies Levels in a Vaccinated Population of Valle de Aburra
Status: UNKNOWN
Conditions: COVID-19
Interventions: DIAGNOSTIC_TEST: Levels of IgG and IgM SARS-CoV-2 antibodies blood test.|DIAGNOSTIC_TEST: RT-PCR SARS-CoV-2 nasopharyngeal swab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of a Fully Covered Self-Expandable Metal Stent for Unresectable HCC
Status: RECRUITING
Conditions: Malignant Biliary Obstruction|Hepatocellular Carcinoma
Interventions: PROCEDURE: Endoscpic biliary drainage using fully covered metal stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parent-focused Primary Prevention of Child Sexual Abuse: An Effectiveness-implementation Hybrid Trial
Status: NOT_YET_RECRUITING
Conditions: Child Sexual Abuse
Interventions: BEHAVIORAL: Parents as Teachers (PAT) as usual|BEHAVIORAL: Parents as Teachers (PAT) + Smart Parents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Allogeneic Stem Cell Transplant With Alpha/Beta T AND B Cell Depletion for Hematologic Malignancies
Status: RECRUITING
Conditions: Leukemia|Lymphoma|Myelodysplasia
Interventions: DEVICE: Alpha Beta T cell depletion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultra Low Dose Radiation Delivered Before or After Chemotherapy-Free Targeted Therapy in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma
Status: RECRUITING
Conditions: Recurrent Mantle Cell Lymphoma|Refractory Mantle Cell Lymphoma
Interventions: DRUG: Low Dose Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ixabepilone and Liposomal Doxorubicin in Advanced Ovarian Cancer
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Female Reproductive Cancer|Recurrent Breast Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Breast Cancer|Stage IV Ovarian Epithelial Cancer
Interventions: DRUG: ixabepilone|DRUG: pegylated liposomal doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus
Status: RECRUITING
Conditions: Lupus Erythematosus, Systemic
Interventions: DRUG: Litifilimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Circulating Blood Cell Monocytes as Predictive Biomarker of Bone Cystic Fibrosis Disease. Impact of CFTR Correctors.
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: BIOLOGICAL: Blood test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Avdoralimab an Anti-C5aR Antibody, in Patients With COVID-19 Severe Pneumonia ( FORCE )
Status: COMPLETED
Conditions: COVID
Interventions: BIOLOGICAL: avdoralimab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Resistant Starch on Glycemic Response in Older Adults
Status: COMPLETED
Conditions: Hyperglycemia
Interventions: DIETARY_SUPPLEMENT: Resistant Starch Type 4|DIETARY_SUPPLEMENT: Dextrose|DIETARY_SUPPLEMENT: Puffed wheat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Status of HRD That Lead to a Benefit From Olaparib in Combination With Bevacizumab (STROBE Trial)
Status: RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: Bevacizumab|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Lightweight Meshes in Laparoscopic Inguinal Hernia Repair on Quality of Life and Male Fertility Aspects
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: PROCEDURE: laparoscopic (TEP) inguinal hernia repair|DEVICE: lightweight TiMesh|DEVICE: lightweight VyproII|DEVICE: Heavyweight Marlex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of CES on Parasympathetic Tone
Status: COMPLETED
Conditions: Autonomic Nervous System Imbalance
Interventions: DEVICE: Cranial Electrical Stimulation Fisher-Wallace Stimulator (Model FW100)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison Study Between C13-CAC Breath Test and 24-hour Gastric pH Monitoring
Status: COMPLETED
Conditions: Gastric Acid-related Diseases|Healthy
Interventions: DRUG: Calcium (13C)Carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Adenocarcinoma|Estrogen Receptor Negative|HER2/Neu Negative|Progesterone Receptor Negative|Stage IB Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer|Stage IIIC Breast Cancer|Triple-Negative Breast Carcinoma
Interventions: DRUG: Carboplatin|DRUG: Cyclophosphamide|DRUG: Doxorubicin Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Denosumab and Pembrolizumab in Clear Cell Renal Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma, Clear Cell|Metastatic Kidney Cancer
Interventions: DRUG: Pembrolizumab plus denosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Levels of BMS-986036 in Blood Plasma in Healthy, Overweight, and Obese Participants Following Subcutaneous Administration Via Auto-injector Versus Pre-filled Syringe
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: BMS-986036
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ARRY-614 Plus Either Nivolumab or Nivolumab+Ipilimumab
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma|Melanoma|Solid Tumor|Non-small Cell Lung Cancer|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Phase Ib ARRY-614 + nivolumab|DRUG: Phase Ib ARRY-614 + nivolumab+ipilimumab|DRUG: Phase II ARRY-614 + nivolumab|DRUG: Phase II ARRY-614 + nivolumab+ipilimumab (melanoma)|DRUG: Phase II ARRY-614 + nivolumab+ipilimumab (RCC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Procedures for Improving the Mucosa Around Implants
Status: COMPLETED
Conditions: Keratinized Mucosa|Dental Implants
Interventions: PROCEDURE: Apically positioned flap|PROCEDURE: Free Gingival Graft|PROCEDURE: apically positioned flap with Mucograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Investigating the Effects of Semaglutide on ß-cell Function in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: semaglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non Invasive Characterization of Pediatric Inflammatory Bowel Diseases Using Multispectral Optoacoustic Tomography
Status: COMPLETED
Conditions: Crohn's Disease|Ulcerative Colitis|IBD
Interventions: DEVICE: Multispectral Optoacoustic Tomography (MSOT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adjuvant Chemotherapy Combined With Targeted Therapy or Not in the T3-4N2 Colorectal Cancer Patients
Status: RECRUITING
Conditions: Colorectal Cancer|Chemotherapy Effect
Interventions: DRUG: FOLFOX chemotherapy regimens|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NUPRO(r) Sensodyne Prophylaxis Paste With NovaMin(r)Sensitivity Relief Study
Status: COMPLETED
Conditions: Tooth Hypersensitivity
Interventions: DEVICE: NUPRO Classic Prophy Paste|DEVICE: NUPRO Sensodyne Prophy Paste with Novamin with fluoride.|DEVICE: NUPRO Sensodyne Prophy Paste with Novamin without fluoride.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Clinical Study of TPX-115 in Patients With Partial-Thickness Rotator Cuff Tear
Status: COMPLETED
Conditions: Rotator Cuff Injuries
Interventions: BIOLOGICAL: TPX-115|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Total Hip Arthroplasty
Status: COMPLETED
Conditions: Prevention|Venous Thromboembolism
Interventions: DRUG: edoxaban|DRUG: enoxaparin sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: First Human Dose Study of Anti-IL-20 in Psoriasis: A Study of Safety, Tolerability and Early Signals of Biologic and Clinical Effects
Status: TERMINATED
Conditions: Inflammation|Psoriasis
Interventions: DRUG: anti-IL-20|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-ranging Study of SKF7™ for Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: low-dose|DRUG: Middle-dose|DRUG: Higher-dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Life-long Tele-monitoring of Patients With Type 2 Diabetes Mellitus in Central Greece
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: PROCEDURE: Telemonitoring of patients with diabetes type 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Methamphetamine, PrEP, and Intersectional Stigma Study
Status: NOT_YET_RECRUITING
Conditions: Methamphetamine Abuse|Hiv|Social Stigma
Interventions: BEHAVIORAL: Methamphetamine, PrEP, and Intersectional Stigma (eMPrISe) study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessing Safety and Performance of the ANA Catheter System, Combined With a Stent Retriever in Acute Ischemic Stroke
Status: TERMINATED
Conditions: Stroke, Ischemic
Interventions: DEVICE: Neurothrombectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-power Pain Thershold Ultrasound Versus Myofascial Release in Patients With Chronic Plantar Fasciitis
Status: NOT_YET_RECRUITING
Conditions: Plantar Fascitis
Interventions: DEVICE: Ultrasound|OTHER: Myofascial release technique|OTHER: Strength and stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Study of Multiple Doses of CM-101 in Male and Female NAFLD (Nonalcoholic Fatty Liver Disease) and NAFLD/NASH (Nonalcoholic Steatohepatitis) Subjects
Status: COMPLETED
Conditions: Nonalcoholic Fatty Liver Disease
Interventions: DRUG: Anti-human CCL24 monoclonal antibody (CM-101) - Part One|DRUG: Anti-human CCL24 monoclonal antibody (CM-101) - Part Two|DRUG: Placebo - Study Part One|DRUG: Placebo - Study Part Two
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immediate Effects of Proximal and Distal Acupoints on the RPPW in Patients With KOA: a Randomized Controlled Trial
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: OTHER: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Families Improving Together (FIT) for Weight Loss
Status: COMPLETED
Conditions: Overweight|Obese
Interventions: BEHAVIORAL: Motivational and Family Weight Loss|BEHAVIORAL: Basic Health Education|BEHAVIORAL: Online Intervention|BEHAVIORAL: Online Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Activation and Walking Speed of the Prefrontal Cortex of the Elderly Mild Cognitive Impairment During Dual Task.
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Dual Task
Interventions: BEHAVIORAL: Seniors with mild cognitive impairment over 65 years of age
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Single-Blind, Randomized Study to Compare fCO2 Laser Therapy Versus Sham for Treatment of SUI in Women
Status: WITHDRAWN
Conditions: Stress Urinary Incontinence|Urinary Incontinence
Interventions: DEVICE: Active fCO2 laser treatment|DEVICE: Sham fCO2 laser treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thyroxin Treatment in Sub Clinical Hypothyroidism, on the Apnea Hypopnea Index Score, Lipids and Highly Sensitive CRP
Status: UNKNOWN
Conditions: Dyslipidemia
Interventions: DRUG: levothyroxine|DRUG: sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cartilage Repair Using a Hyaluronic Acid-Based Scaffold With Bone Marrow Aspirate Compared With Microfracture for Focal Articular Cartilage Damage of the Hip
Status: WITHDRAWN
Conditions: Femoroacetabular Impingement|Cartilage Damage
Interventions: DEVICE: HA-based scaffold with BMA (Hyalofast®; Anika Therapeutics, Bedford, MA, USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Multimodal Lifestyle Intervention on Chronic Fatigue in Patients With Inflammatory Bowel Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Inflammatory Bowel Diseases|Fatigue
Interventions: BEHAVIORAL: Lifestyle intervention: Live with IBD|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Aromatase Inhibitors on Bones and Genes
Status: COMPLETED
Conditions: Breast Cancer|Postmenopausal
Interventions: PROCEDURE: Dual x-ray absorptiometry (DXA)|PROCEDURE: Blood draw|BEHAVIORAL: Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety Study of the Use of Topical Cyclosporine in the Treatment of Dry Eye Disease
Status: COMPLETED
Conditions: Primary Sjogren Syndrome|Secondary Sjogren Syndrome|Aqueous Deficient Dry Eye Disease|Evaporative Dry Eye Disease
Interventions: DRUG: Restasis|DRUG: Refresh Endura
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interferon Alfa With or Without Vaccine Therapy in Treating Patients With Metastatic Melanoma
Status: UNKNOWN
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: Detox-B adjuvant|BIOLOGICAL: recombinant interferon alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparison Between Two Different Protocols in Polycystic Ovary Symdrome Women Undergoing Intra-cytoplasmic Injection
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Cetrorelix|DRUG: Leuprolide Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia
Status: RECRUITING
Conditions: Severe Aplastic Anemia
Interventions: DRUG: Cohort 1: hATG, CsA, EPAG Day 14 to Month 6|DRUG: Cohort 2: hATG, CsA, EPAG Day 14 to Month 3|DRUG: Cohort 3: hATG, CsA (dose reduced), EPAG day 1 to month 6|DRUG: Extension Cohort
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Extended Field IMRT External Beam Irradiation and Intracavitary Brachytherapy
Status: TERMINATED
Conditions: Cervical Cancer
Interventions: RADIATION: IMRT extended field external beam radiation therapy|RADIATION: Brachytherapy|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Antiviral Medications in Controlling Vertigo Attacks of Patients With Meniere's Disease
Status: UNKNOWN
Conditions: Meniere's Disease
Interventions: DRUG: Acyclovir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Erlotinib Hydrochloride With or Without Cixutumumab in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Recurrent Non-small Cell Lung Cancer|Stage IIIA Non-small Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: cixutumumab|DRUG: erlotinib hydrochloride|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Next Generation Sequencing（NGS）Monitors Minimal Residual Disease（MRD）in Allo-PBSCT Patients
Status: UNKNOWN
Conditions: NGS Monitor MRD
Interventions: DIAGNOSTIC_TEST: NGS patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: BOTOX® for the Treatment of Platysma Prominence
Status: COMPLETED
Conditions: Platysma Prominence
Interventions: DRUG: BOTOX® purified neurotoxin complex|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Messages for Increasing Dairy Consumption
Status: COMPLETED
Conditions: Dietary Modification
Interventions: BEHAVIORAL: Gain-Framed|BEHAVIORAL: Loss-Framed|BEHAVIORAL: Self-Regulatory Efficacy|BEHAVIORAL: Gain-Framed + Self-Regulatory Efficacy|BEHAVIORAL: Loss-Framed + Self-Regulatory Efficacy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Photobiomodulation With Polarized Light as Adjunctive Treatment in Diabetic Foot Ulcer
Status: COMPLETED
Conditions: Wound Healing Disorder
Interventions: RADIATION: polarized light|OTHER: Medical Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cannulation-Related Pain in Dialysis Patients With Arteriovenous Fistula
Status: COMPLETED
Conditions: Hemodialysis Access
Interventions: OTHER: KaleidoscopeGroup|OTHER: Ice Application Group|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Surveillance of Efficacy and Safety of Drug PRITOR in patieNts With Arterial Hypertension, Who do Not Tolerate ACE inhibitoR Treatment
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Kinzal/Pritor (Telmisartan, BAY68-9291)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Three-dimensional Perception of Sounds in Military With Acoustic Trauma
Status: RECRUITING
Conditions: Hearing Loss
Interventions: DIAGNOSTIC_TEST: SPHERE protocol : Spatial hearing performances test|DIAGNOSTIC_TEST: French Matrix Test : audiology test of speech in noise perception|BEHAVIORAL: SSQ15 questionnaire of life : (The Speech, Spatial and Other Qualities of Hearing Scale)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Nella Women's Care Line
Status: COMPLETED
Conditions: GYN Disorders
Interventions: DEVICE: Group 1: Nella VuSleeve|DEVICE: Group 2: Nella NuSpec|DEVICE: Group 3: NellaSpec|DEVICE: Group 4: Nella Insert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Hematopoietic Stem Cell Transplantation Gene Therapy for Treatment of Severe Hemophilia A
Status: COMPLETED
Conditions: Hemophilia A
Interventions: BIOLOGICAL: Auto CD34+PBSC transduced with a lentiviral vector encoding a novel coagulation factor VIII transgene
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Potential Role for Oxygen in the Development of Mental Fatigue and the Subsequent Decline in Cognitive Performance
Status: UNKNOWN
Conditions: Mental Fatigue|Near Infrared Spectroscopy|NIRS|Hypoxia|Cerebral Heamodynamics|Cognition
Interventions: OTHER: Hypoxia|OTHER: Normoxia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Biochemical Diagnostics of Mild Traumatic Brain Injury (TBI) and Concussion in Children and Adolescents
Status: COMPLETED
Conditions: Brain Injuries, Traumatic
Interventions: DIAGNOSTIC_TEST: Sample collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: To Determine the Feasibility of a Clinical Trial Comparing Anticoagulants Versus Antiplatelets in the Acute Treatment of Patients With Cervical Artery Dissection
Status: COMPLETED
Conditions: Cervical Artery Dissection|Carotid Artery Dissection|Vertebral Artery Dissection|Stroke
Interventions: DRUG: Antiplatelet (Aspirin, Dipyridamole, clopidogrel)|DRUG: Anticoagulant (Unfractionated Heparin, LMW Heparin, Warfarin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Trial of Preoperative 5-Day Hypofractionated Radiotherapy for Primary Soft Tissue Sarcoma
Status: RECRUITING
Conditions: Soft Tissue Sarcoma
Interventions: RADIATION: Hypofractionated Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Whether Multiple Doses of BI 456906 Have an Effect on Cardiac Safety in People With Overweight or Obesity
Status: RECRUITING
Conditions: Overweight|Obesity
Interventions: DRUG: BI 456906|DRUG: Placebo to BI 456906|DRUG: Moxifloxacin|DRUG: Placebo to moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Pharmacodynamics of Long Acting Human Growth Hormone (hGH) Product (MOD-4023) in Healthy Caucasian and Japanese Volunteers
Status: COMPLETED
Conditions: Growth Hormone Deficiency
Interventions: DRUG: MOD-4023|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Obstructive Sleep Apnea, Predictors and Bariatric Surgery
Status: COMPLETED
Conditions: Obesity|Obstructive Sleep Apnea|Bariatric Surgery Candidate
Interventions: PROCEDURE: Bariatric surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prediction AlgoriThm for regeneraTive Medicine Approach in knEe OA: New Decision-making Process Based on Patient pRofiliNg
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: KIT BMAC AND at-SVF FIDIA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison Synthetic Hydroxyapatite and Inorganic Bovine Bone in Sinus Floor Elevation
Status: COMPLETED
Conditions: Alveolar Bone Loss
Interventions: PROCEDURE: sinus floor augmentation with bone graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Psychological Treatments for Scleroderma
Status: COMPLETED
Conditions: Pain|Depression|Scleroderma|Systemic Sclerosis
Interventions: BEHAVIORAL: Cognitive behavioral therapy|BEHAVIORAL: Disease/health education|BEHAVIORAL: Self-help cognitive behavioral intervention facilitated by a psychologist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Anti-PD-1 AK105 in Patients With Metastatic Nasopharyngeal Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: BIOLOGICAL: AK105
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study In Neuromyelitis Optica Spectrum Disorder (NMOSD) With Satralizumab As An Intervention
Status: TERMINATED
Conditions: Neuromyelitis Optica Spectrum Disorder|NMOSD
Interventions: DRUG: Satralizumab 120 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Case Formulation Approach to Cognitive Processing Therapy
Status: RECRUITING
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Case Formulation plus Cognitive Processing Therapy|BEHAVIORAL: Cognitive Processing Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study to Determine the Safety and Efficacy of Interferon-gamma in Patients With Chronic Hepatitis B
Status: UNKNOWN
Conditions: Hepatitis B
Interventions: DRUG: IFN-γ 1b (Actimmune)|DRUG: Adefovir dipivoxil|DRUG: IFN-γ 1b and Adefovir dipivoxil combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BuCE Versus BuME as Conditioning Therapy in Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-hodgkin Lymphoma
Interventions: DRUG: Busulfan|DRUG: Cyclophosphamide|DRUG: Etoposide|DRUG: Melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CID-103 (Anti-CD38 Antibody) in Previously Treated Relapsed or Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: CID-103
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychosocial Pain Management During Addictions Treatment to Improve Outcomes
Status: COMPLETED
Conditions: Pain
Interventions: BEHAVIORAL: Psychoeducation for substance abuse|BEHAVIORAL: CBT for pain in Substance abuse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Early Intensification of Antiretroviral Therapy Including Enfuvirtide in HIV-1-Related Progressive Multifocal Leucoencephalopathy (ANRS125)
Status: COMPLETED
Conditions: Leukoencephalopathy, Progressive Multifocal|HIV Infections
Interventions: DRUG: Enfuvirtide|DRUG: Tenofovir-Emtricitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total-Body Irradiation, Thiotepa, and Fludarabine in Treating Young Patients Who Are Undergoing a Donor Stem Cell Transplant for Hematologic Cancer
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: fludarabine phosphate|DRUG: thiotepa|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Sodium Phenylbutyrate, Sodium Benzoate, Sodium Phenylacetate, and Dietary Intervention for Urea Cycle Disorders
Status: COMPLETED
Conditions: Amino Acid Metabolism, Inborn Errors
Interventions: DRUG: Sodium Benzoate|DRUG: Sodium Phenylacetate|DRUG: Sodium Phenylbutyrate|BEHAVIORAL: Dietary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Percutaneous Coronary Intervention With the Angiolite Drug-eluting Stent: an Optical Cohenrece Tomography Study
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DEVICE: Angiolite stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Improved Functioning Among People Experiencing Stressful Situations
Status: NOT_YET_RECRUITING
Conditions: Acute Stress Reaction
Interventions: BEHAVIORAL: iCOVER|BEHAVIORAL: Physical Presence with Reassurance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION