pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Stereotactic Management of Arrhythmia - Radiosurgery Treatment and Evaluation of Response in Ventricular Tachycardia
Status: RECRUITING
Conditions: Ventricular Tachycardia
Interventions: RADIATION: Stereotactic Body Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety of GABITRIL in Adults With Generalized Anxiety Disorder
Status: COMPLETED
Conditions: General Anxiety Disorder
Interventions: DRUG: GABITRIL (tiagabine hydrochloride; CEP-6671)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Providing Online Counseling for Home-Based HIV Testing With Transgender Youth
Status: COMPLETED
Conditions: Hiv|Transgender Youth
Interventions: BEHAVIORAL: at-home test kit|BEHAVIORAL: Motivational Interviewing and Certified Testing and Referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Hypofractionated Radiotherapy in Locally Advanced Myxoid Liposarcomas of Extremities or Trunk Wall (LIPO-MYX Trial)
Status: UNKNOWN
Conditions: Myxoid Liposarcoma
Interventions: RADIATION: Hypofractionated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modified Tumor Infiltrating Lymphocytes for Metastatic Melanoma
Status: TERMINATED
Conditions: Metastatic Melanoma|Skin Cancer
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|BIOLOGICAL: Aldesleukin|BIOLOGICAL: Tumor Infiltrating Lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Partial and Exclusive Enteral Nutrition in the Treatment of Active Childhood-onset Crohn's Disease
Status: UNKNOWN
Conditions: Adolescent|Child|Diet|Crohn Disease|Enteral Nutrition|Remission
Interventions: OTHER: ALICALM (75% of daily caloric requirements)|OTHER: ALICALM (100% of daily caloric requirements)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Four Dosing Regimens of PROCRIT (Epoetin Alfa) in Patients With Chronic Kidney Disease. Protocol Addendum: Extension Study of Maintenance Therapy of PROCRIT (Epoetin Alfa) in Patients With Chronic Kidney Disease.
Status: COMPLETED
Conditions: Chronic Kidney Disease|Anemia
Interventions: DRUG: epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erlotinib in Post Radical Operation NSCLC Patients With EGFR Mutation
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer Stage III
Interventions: DRUG: Erlotinib|DRUG: cis-platinum|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Navy Beans and Yellow Peas on Satiety in Children
Status: COMPLETED
Conditions: Food|Eating|Satiety|Physical Comfort
Interventions: OTHER: Food-1|OTHER: Food-2|OTHER: Food-3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Open Label Safety And Efficacy Study Of Pregabalin In Subjects With Nerve Pain Asociated With Human Immunodeficiency Virus (HIV) Neuropathy
Status: COMPLETED
Conditions: Peripheral Neuropathy|HIV Infections
Interventions: DRUG: pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of a Mindfulness and Self-Compassion Program in Patients With Schizophrenia. Randomized Controlled Trial.
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Mindful Self-Compassion Program|BEHAVIORAL: Cognitive Behaviour Therapy Group|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imatinib Treatment in Recent Onset Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type I|Diabetes Mellitus, Insulin-Dependent, 1|Type 1 Diabetes Mellitus|Insulin-Dependent Diabetes Mellitus 1|IDDM
Interventions: DRUG: Imatinib Mesylate|DRUG: Placebo (For imatinib mesylate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Study to Evaluate Rosuvastatin in Children and Adolescents With Familial Hypercholesterolaemia
Status: COMPLETED
Conditions: Familial Hypercholesterolaemia
Interventions: DRUG: rosuvastatin calcium|DRUG: rosuvastatin calcium|DRUG: rosuvastatin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Ascending Dose Study To Assess The Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of AZD9567.
Status: COMPLETED
Conditions: Safety|Tolerability|Pharmacokinetics|Pharmacodynamics|Healthy Subjects|Rheumatoid Arthritis
Interventions: DRUG: AZD9567 Monohydrat|DRUG: Placebo oral suspension/ Placebo capsule|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Memantine for the Treatment of Social Deficits in Youth With Disorders of Impaired Social Interactions
Status: RECRUITING
Conditions: Autism|Autism Spectrum Disorder|Nonverbal Learning Disability
Interventions: DRUG: Memantine Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intranasal PH80 Spray for Acute Management of the Symptoms of Premenstrual Dysphoric Disorder
Status: UNKNOWN
Conditions: Premenstrual Dysphoric Disorder
Interventions: DRUG: PH80|DRUG: Placebo intranasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability of MDMA in Schizophrenia
Status: NOT_YET_RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: MDMA 40mg|DRUG: MDMA 80mg|DRUG: MDMA 120mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Coronary Calcification in Subjects With Autosomal Dominant Familial Hypercholesterolemia Heterozygous
Status: COMPLETED
Conditions: Familial Hypercholesterolemia - Heterozygous
Interventions: RADIATION: CAC Score
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Local Culture-Based Nutrition Education Intervention on Iron Supplement Tablets (IST) Consumption Compliance in Female Adolescents at Ogan Komering Ilir Regency: A Quasi-Experimental Protocol Study
Status: COMPLETED
Conditions: Anemia|Iron Deficiency Anemia
Interventions: DIETARY_SUPPLEMENT: Iron Supplement Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Cerebellar Deep Brain Stimulation for Movement Disorders in Cerebral Palsy in Children and Young Adults
Status: RECRUITING
Conditions: Dyskinetic Cerebral Palsy|Dystonic Cerebral Palsy
Interventions: DEVICE: DBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prophylactic HIV Vaccine Trial to Evaluate the Safety and Immunogenicity of HIV Clade C DREP Alone and in Combination With a Clade C ENV Protein in Healthy HIV-uninfected Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Adults
Interventions: BIOLOGICAL: Drep-HIV-PT1 0.2mg and CN54gp140/MPLA-L|BIOLOGICAL: DREP-HIV-PT1 1mg and CN54gp140/MPLA-L (see above)|BIOLOGICAL: DNA-HIV-PT123 4mg and CN54gp140/MPLA-L
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Lenalidomide and Dexamethasone With or Without Thalidomide in Treating Patients With Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: DS Stage I Multiple Myeloma|DS Stage II Multiple Myeloma|DS Stage III Multiple Myeloma
Interventions: DRUG: Dexamethasone|OTHER: Laboratory Biomarker Analysis|DRUG: Lenalidomide|DRUG: Thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Combination of ATX-101 and Platinum-based Chemotherapy
Status: TERMINATED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Carcinoma|High Grade Serious or Endometrioid Carcinoma of the Ovary, Fallopian Tube, or Primary Peritoneal Cancer
Interventions: DRUG: ATX-101 + Carboplatin + Pegylated liposomal doxorubicin (ACD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Radiofrequency Ablation Versus Hybrid Argon Plasma Coagulation in the Treatment of Barrett's Esophagus
Status: UNKNOWN
Conditions: Barrett Esophagus|Esophageal Adenocarcinoma|Reflux Disease
Interventions: PROCEDURE: Endoscopic radiofrequency ablation|PROCEDURE: Endoscopic hybrid argon plasma coagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation (rTMS) on Neurogenic Overactive Bladder in Stroke
Status: COMPLETED
Conditions: Urgency Urinary Incontinence|Overactive Bladder
Interventions: DEVICE: Repetitive transcranial magnetic stimulation|DEVICE: Sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Adaptation of Alveolar-capillary Diffusion at Effort of Subjects Suffering From Complex Congenital Heart Disease
Status: COMPLETED
Conditions: Complex Congenital Heart Disease|Single Ventricle With Fontan Circulation or Bicavo-bipulmonary Bypass|Systemic Right Ventricle|Pulmonary Failure
Interventions: OTHER: Double pulmonary diffusing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Duvelisib in Combination With Rituximab and Bendamustine vs Placebo in Combination With Rituximab and Bendamustine in Subjects With Previously-Treated Indolent Non-Hodgkin Lymphoma (BRAVURA)
Status: WITHDRAWN
Conditions: Indolent Non-Hodgkin's Lymphoma|Follicular Lymphoma|Small Lymphocytic Lymphoma|Marginal Zone Lymphoma
Interventions: DRUG: Duvelisib|DRUG: Placebo|DRUG: Rituximab|DRUG: Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Clinical Trial to Evaluate the Safety of 15-valent HPV Vaccine in Healthy Chinese People Aged 18-45 Years
Status: RECRUITING
Conditions: HPV Infection|HPV-Related Carcinoma|Genital Wart|HPV-Related Intraepithelial Neoplasia
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: 15-valent recombinant human papillomavirus vaccine (Hansenulapolymorpha)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: This is an Open-label, Single Arm Study to Evaluate the Safety and Tolerability of Treatment With CT0591CP in Patients With Relapsed and/or Refractory Multiple Myeloma.
Status: RECRUITING
Conditions: Relapsed and/or Refractory Multiple Myeloma
Interventions: BIOLOGICAL: CT0591CP Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rifaximin and Placebo in the Treatment of Bowel Dysfunction After Anterior Resection for Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DRUG: Rifaximin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Online Program Assisting Lifestyle Changes (Asterix 1.0 & Obelix 2.0)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Intervention Group (IG)|BEHAVIORAL: Active Control Group (ACG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of mRNA-1010 Seasonal Influenza Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Seasonal Influenza
Interventions: BIOLOGICAL: mRNA-1010|BIOLOGICAL: Placebo|BIOLOGICAL: Active Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Use of Etanercept Enbrel as Sole Treatment for Grade I Acute Graft Versus Host Disease
Status: COMPLETED
Conditions: Acute Graft Versus Host Disease
Interventions: DRUG: Etanercept (Enbrel)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Learning Direct Laryngoscopy Using a McGrath Video Laryngoscope as Direct Versus Indirect Laryngoscope
Status: COMPLETED
Conditions: Airway Management|Endotracheal Intubation|Medical Education
Interventions: PROCEDURE: direct laryngoscope|PROCEDURE: video laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Safety Study of DNA Vaccine Delivered by Intradermal Electroporation to Treat Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: tetwtCEA DNA (wt CEA with tetanus toxoid Th epitope)|DEVICE: Derma Vax (electroporation device)|BIOLOGICAL: GM-CSF|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypertension and Diabetes Assessment in the Rohingya Refugee Population and in the Host Communities in Bangladesh
Status: UNKNOWN
Conditions: Hypertension|Diabetes Mellitus|Post Traumatic Stress Disorder|Depressive Symptoms
Interventions: DIAGNOSTIC_TEST: Blood pressure measurement (sphygmomanometer)|DIAGNOSTIC_TEST: Blood glucose measurement|OTHER: psychometric tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunogenicity and Safety of GlaxoSmithKline Biologicals' MMRV Vaccine vs. ProQuad® in Children 12-14 Months of Age
Status: COMPLETED
Conditions: Varicella|Rubella|Mumps|Measles
Interventions: BIOLOGICAL: Priorix-Tetra™ (MMRV vaccine 208136)|BIOLOGICAL: ProQuad®|BIOLOGICAL: Havrix®|BIOLOGICAL: Prevnar®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hemodynamic Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension
Status: COMPLETED
Conditions: Hypertension, Pulmonary
Interventions: OTHER: Normobaric hypoxia (FiO2 15%)|OTHER: Placebo-ambient air (FiO2 21%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Bioelectrical Impedance Analysis in Estimating Body Composition in Patients With Stage I-IV Head and Neck Cancer Undergoing Radiation Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Carcinoma
Interventions: PROCEDURE: Bioelectric Impedance Analysis|PROCEDURE: Computed Tomography|PROCEDURE: Positron Emission Tomography|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Palatinose™ Versus Sucrose on Flow Mediated Dilation in Healthy Subjects With Mild Hypertension
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: isomaltulose|DIETARY_SUPPLEMENT: sucrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of the JAK Inhibitor Ruxolitinib Administered Orally to Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera-Myelofibrosis (PPV-MF) or Post-Essential Thrombocythemia-Myelofibrosis (PET-MF)
Status: COMPLETED
Conditions: Myelofibrosis
Interventions: DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Clinical Feasibilityof a Multi-modal Photoacoustic/Ultrasonic Imaging System in Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Ultrasonography
Interventions: DIAGNOSTIC_TEST: Multi-modal photoacoustic/ultrasonic (PA/US) imaging system
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hydroxychloroquine in Blocking Autophagy in Patients With Prostate Cancer Undergoing Surgery or Active Surveillance
Status: TERMINATED
Conditions: Prostate Carcinoma
Interventions: DRUG: Hydroxychloroquine|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuropsychological Effects of Hydrocortisone in Patients With Partial Adrenal Insufficiency
Status: TERMINATED
Conditions: Partial Corticotrope Insufficiency
Interventions: DRUG: Hydrocortisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LOSE-AF: Can Weight Loss Help Patients With Atrial Fibrillation?
Status: RECRUITING
Conditions: Atrial Fibrillation|Overweight and Obesity
Interventions: OTHER: Meal Replacement Weight Loss Programme|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of EB05 + SOC vs. Placebo + SOC in Adult Hospitalized Patients With COVID-19
Status: RECRUITING
Conditions: COVID-19|ARDS
Interventions: BIOLOGICAL: SOC plus 15mg/kg EB05 IV|OTHER: SOC plus Placebo IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Janus Kinase Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction
Status: RECRUITING
Conditions: Diaphragm Injury
Interventions: DRUG: Tofacitinib 10 MG [Xeljanz]|DRUG: Placebo to match Tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Neuroimaging Study of Bupropion Treatment in Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Bupropion, Escitalopram|DRUG: Escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Safety of LT5001 Drug Product for Uremic Pruritus in Hemodialysis Patients
Status: UNKNOWN
Conditions: Uremic Pruritus
Interventions: DRUG: LT5001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Tildrakizumab in the Treatment of Nail Psoriasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Plaque Psoriasis|Moderate to Severe Nail Psoriasis
Interventions: DRUG: Tildrakizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Guided User-initiated Insulin Dose Enhancements (GUIDE) to Improve Outcomes for Youth With Type 1 Diabetes
Status: WITHDRAWN
Conditions: Type 1 Diabetes
Interventions: DEVICE: Automated Insulin Dose Adjustment|DEVICE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Bioequivalence of a New ULTRACET Extended Release (ER) Tablet With Respect to a Marketed ULTRACET ER Tablet Under Fasted Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tramadol HCl 75 mg/Acetaminophen 650 mg (Newly developed ULTRACET ER)|DRUG: Tramadol HCl 75 mg/Acetaminophen 650 mg (Marketed ULTRACET ER)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Genasense in Subjects With Normal Renal Function, Mildly Impaired Renal Function, and Moderately Impaired Renal Function
Status: COMPLETED
Conditions: Normal Renal Function|Mildly Impaired Renal Function|Moderately Impaired Renal Function
Interventions: DRUG: Genasense (oblimersen, G3139)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of the Dayspring Technology for Patients With Breast Cancer Related Lymphedema (BCRL) After Lymphatic Surgery
Status: UNKNOWN
Conditions: Lymphedema|Lymphedema, Breast Cancer|Lymphedema Arm
Interventions: DEVICE: Dayspring Active Wearable Compression System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temozolomide and Irinotecan in Patients With MGMT Silenced Colorectal Cancer After Adjuvant Chemotherapy
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: Irinotecan|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ambulatory Medication Reconciliation Following Hospital Discharge
Status: UNKNOWN
Conditions: Medication Administered in Error|Adverse Drug Events
Interventions: OTHER: Outpatient Medication Reconciliation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An Exploratory Study of Naltrexone Plus Aripiprazole for Alcohol Dependence
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: Placebo|DRUG: Naltrexone|DRUG: Naltrexone + Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Machine-Based And Manually Applied Hand Massage On Pain, Anxiety And Gastrointestinal System Functions After Laparoscopic Cholecystectomy Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Laparoscopic Cholecystectomy
Interventions: OTHER: Manual hand massage after laparoscopic cholecystectomy surgery|OTHER: Machine-based hand massage after laparoscopic cholecystectomy surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Investigational Immuno-Therapy Study of Experimental Medication BMS-986178 by Itself or in Combination With Nivolumab and/or Ipilimumab in Participants With Solid Cancers That Are Advanced or Have Spread
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: DRUG: BMS-986178|DRUG: Nivolumab|DRUG: Ipilimumab|BIOLOGICAL: Tetanus vaccine|BIOLOGICAL: DPV-001 vaccine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of T1N0 Invasive Breast Carcinoma by Local Excision Implant
Status: COMPLETED
Conditions: Breast Cancer
Interventions: RADIATION: Interstitial Implant Brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Orthopaedic Treatment in Propulsive Metatarsalgia
Status: COMPLETED
Conditions: Metatarsalgia|Treatment|Foot|Foot Diseases|Orthopedic Disorder|Subluxation of Toe Joint|Toe Joint Deformity
Interventions: DEVICE: EVA plantar orthosis|DEVICE: Polypropylene plantar orthosis|DEVICE: Fixtoe device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: FST-201 in the Treatment of Acute Otitis Externa
Status: COMPLETED
Conditions: Acute Otitis Externa
Interventions: DRUG: FST201 (dexamethasone 0.1% with povidone-iodine 1%)|DRUG: Ciprodex (Ciprofloxacin 0.3%; dexamethasone 0.1% )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Venetoclax, Rituximab and Ibrutinib in TN Patients With CLL Undetectable Minimal Residual Disease (uMRD) in Treatment-naïve Patients With Chronic Lymphocytic Leukemia (CLL)
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia (CLL)
Interventions: DRUG: Venetoclax|DRUG: Rituximab|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Naive T-Cell Depleted DLI Following Allo Stem Cell Transplant
Status: COMPLETED
Conditions: Hematological Malignancies
Interventions: BIOLOGICAL: Naive T Cell Depleted Donor Lymphocyte Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent and Daily Dosing for Episodic (Periodic) Asthma (0476-302)(COMPLETED)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: montelukast sodium|DRUG: Comparator: Placebo (unspecified)|DRUG: montelukast sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating New Formulation of Therapeutic HSV-2 Vaccine
Status: COMPLETED
Conditions: Genital Herpes Simplex Type 2
Interventions: BIOLOGICAL: Matrix-M2|BIOLOGICAL: GEN-003|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Muscular and Cutaneous Sodium Storage by 23Na MRI in Patients With Chronic Adrenal Insufficiency
Status: COMPLETED
Conditions: Adrenal Insufficiency
Interventions: DIAGNOSTIC_TEST: 23Na magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Lenalidomide and Prednisone in Low and Int-1 Myelodysplastic Syndrome (MDS) Non 5q MDS
Status: COMPLETED
Conditions: Myelodysplastic Syndrome|MDS
Interventions: DRUG: Prednisone|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CompARing Long terM Outcomes in Chronic Stroke Survivors Across Investigational Assessments Following a Prescribed Upper Extremity Exercise Program
Status: RECRUITING
Conditions: Chronic Stroke
Interventions: OTHER: Standard Occupational Therapy Arm Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet-based Versus Face-to-face Clinical Care for Tinnitus
Status: COMPLETED
Conditions: Tinnitus
Interventions: BEHAVIORAL: CBT-based internet-intervention for tinnitus|BEHAVIORAL: Face-to-face clinical tinnitus care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Zinc Supplementation on Anthropometric Factors, Apelin and Inflammatory Markers in Obese Individuals
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: zinc sulfate|OTHER: corn starch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of the ID NOW™ CT/NG Test
Status: NOT_YET_RECRUITING
Conditions: Chlamydia Trachomatis Infection|Neisseria Gonorrheae Infection|Asymptomatic Condition
Interventions: DIAGNOSTIC_TEST: ID NOW™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Buzzy System Compared to Topical Anaesthesia During Infiltration Injection in Children.
Status: COMPLETED
Conditions: Local Anaesthesia
Interventions: DEVICE: Buzzy System|DRUG: Topical anesthetic|DRUG: 1.8 ml of 4% articaine hydrochloride with epinephrine 1:100,000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Xylitol Wipes as an Oral Hygiene Protocol for Haemophilic Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Haemophilia
Interventions: OTHER: xylitol wipes|OTHER: placebo wipes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: The Krill Ageing Muscle Mechanisms (KAMM) Study
Status: NOT_YET_RECRUITING
Conditions: Sarcopenia
Interventions: DIETARY_SUPPLEMENT: Vegetable oil|DIETARY_SUPPLEMENT: Krill oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Cadonilimab in Combination With Cisplatin and Nab-paclitaxel in Resectable Head and Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma|Locally Advanced Operable
Interventions: DRUG: Cadonilimab|DRUG: Docetaxel|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Web-Based Decision Aid in Improving Informed Decisions in Patients With Stage 0-IIIA Breast Cancer Considering Contralateral Prophylactic Mastectomy
Status: COMPLETED
Conditions: Stage 0 Breast Cancer|Stage I Breast Cancer|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage II Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer
Interventions: OTHER: Internet-Based Intervention|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Extravalvular Procedure for Surgical Treatment of Ascending Aorta Aneurism
Status: UNKNOWN
Conditions: Ascending Aorta Aneurism|Aortic Insufficiency
Interventions: PROCEDURE: Aortic valve reimplantation using Valsalva prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Silk Sericin Dressing With Collagen for Split-thickness Skin Graft Donor Site Treatment
Status: UNKNOWN
Conditions: Wound Heal|Wound Surgical|Donor Site Complication
Interventions: OTHER: wound dressing application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Prednisone, Vinblastine, Doxorubicin, and Gemcitabine in Elderly Patients With Advanced Stages Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Hodgkin's Disease
Interventions: DRUG: Prednisone|DRUG: Vinblastine|DRUG: Doxorubicin (Adriamycin)|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rheumatoid Arthritis: Comparison of Active Therapies in Patients With Active Disease Despite Methotrexate Therapy
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Etanercept|DRUG: methotrexate|DRUG: Sulfasalazine|DRUG: Hydroxychloroquine|DRUG: Placebo, triple|DRUG: Placebo, etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapy for Pediatric Relapsed or Refractory Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Lymphoma, Lymphoblastic
Interventions: DRUG: Etoposide, cytarabine, vincristine, dexamethasone|DRUG: methotrexate, teniposide, PEG-asparaginase|DRUG: mitoxantrone, cyclophosphamide, mercaptopurine, vinblastine|DRUG: L-asparaginase, erwinia asparaginase|PROCEDURE: chemotherapy, intrathecal chemotherapy, steroid therapy|PROCEDURE: Hematopoietic Stem Cell Transplant|PROCEDURE: Natural Killer (NK) Cell Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ability of L-carnitine to Prevent Heart Damage in Breast Cancer Patients Receiving Anthracycline Chemotherapy
Status: TERMINATED
Conditions: Heart Failure
Interventions: DRUG: L-carnitine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nursing Prehabilitation Intervention Supported With Technology for Vascular Surgery in People With Type 2 Diabetes
Status: RECRUITING
Conditions: Type 2 Diabetes|Lifestyle|Prehabilitation|Vascular Surgery
Interventions: BEHAVIORAL: Prehabilitation Intervention Supported with Technology (Fitbit, glucose sensor and app for diet habits)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Sterile Gauze and Semi-permeable Film Dressing for Hemodialysis Central Venous Catheter
Status: UNKNOWN
Conditions: Infection, Bacterial
Interventions: DEVICE: semi-permeable film|DEVICE: sterile gauze and tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of CA-170 (Oral PD-L1, PD-L2 and VISTA Checkpoint Antagonist) in Patients With Advanced Tumors and Lymphomas
Status: COMPLETED
Conditions: Advanced Solid Tumors or Lymphomas
Interventions: DRUG: CA-170
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Adverse Events and Change in Disease Activity From Intravenous (IV) and Subcutaneous (SC) Lutikizumab in Adult Participants With Active Ulcerative Colitis
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: Lutikizumab Matching Placebo|DRUG: Lutikizumab Matching Placebo|DRUG: Adalimumab Matching Placebo|DRUG: Lutikizumab|DRUG: Lutikizumab|DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ILTHPI - Comparison of Medicament Containing Tetracycline, Metronidazole, Bismuth Versus Amoxicillin, Metronidazole, Clarithromycin
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Tetracycline, Metronidazole, Bismuth subcitrate|DRUG: Amoxicillin, Metronidazole, Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of B. Longum 1714™ on Sleep Quality
Status: COMPLETED
Conditions: Subjective Sleep Quality|Objective Sleep Quality
Interventions: DIETARY_SUPPLEMENT: Probiotic capsule|DIETARY_SUPPLEMENT: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Airway Responsiveness and Treatment Efficacy in Asthmatics
Status: UNKNOWN
Conditions: Asthma
Interventions: DRUG: methacholine|DRUG: adenosine monophosphate|DRUG: leukotriene D4|DEVICE: Astograph Jupiter-21 airway reaction testing apparatus|DRUG: budesonide /formoterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Molecularly Target Therapy With FORFIRINOX in Advanced or Recurrent Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma
Status: UNKNOWN
Conditions: Cholangiocarcinoma of the Extrahepatic Bile Duct|Gallbladder Cancer
Interventions: BIOLOGICAL: conventional chemotherapy(FORFIRINOX) combined with target agents|BIOLOGICAL: conventional chemotherapy(FORFIRINOX)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictive Value of GOCCLES® Device for Early Diagnosis of Oral Potentially Malignant Disorders
Status: RECRUITING
Conditions: Oral Potentially Malignant Disorders|Oral Cancer
Interventions: DEVICE: GOCCLES|DIAGNOSTIC_TEST: Toluidine blue stain|PROCEDURE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma
Status: RECRUITING
Conditions: Malignant Pleural Effusion|Malignant Pleural Mesothelioma|Mesothelioma|Mesotheliomas Pleural|Mesothelioma; Lung|Pleural Effusion, Malignant
Interventions: DRUG: RSO-021
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficacy of Bupivacaine in Supraclavicular Block With or Without Dexmedetomidine
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: DEXmedetomidine|OTHER: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Anemia of Chronic Disease on Chronic Obstructive Pulmonary Disease Patients
Status: COMPLETED
Conditions: Anemia|COPD
Interventions: PROCEDURE: maximal cardiopulmonary exercise testing|PROCEDURE: peripheral blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Safety, Tolerability and Pharmacokinetics of Multiple Rising Doses of Butylated Hydroxytoluene and BI 54903 XX Via Respimat® Soft MistTM Inhaler B in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BHT low|DRUG: BHT medium|DRUG: BHT high|DRUG: BI 54903 XX low|DRUG: BI 54903 XX medium 1|DRUG: BI 54903 XX medium 2|DRUG: BI 54903 XX high|DRUG: Ciclesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: EXOPULSE Mollii Suit, Motor Function & Stroke (EXOSTROKE 2)
Status: RECRUITING
Conditions: Stroke|Spasticity, Muscle|Spastic
Interventions: DEVICE: EXOPULSE Mollii Suit Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Ph1/2 Study of EMB-06 in Participants With Relapsed or Refractory Myeloma
Status: RECRUITING
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: BIOLOGICAL: EMB-06
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of the Efficacy and Safety of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures
Status: COMPLETED
Conditions: Seizures
Interventions: DRUG: CVL-865|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: UCN-01 and Topotecan in Treating Patients With Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cavity Cancer
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: 7-hydroxystaurosporine|DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dexmedetomidine vs Esmolol or Placebo on Cerebral Hemodynamics in Septic Shock
Status: COMPLETED
Conditions: Septic Shock|Stress Response|Cerebral Hemodynamics
Interventions: DRUG: Dexmedetomidine Hydrochloride|DRUG: Esmolol Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Chen Taichi on College Students' Physical and Psychological Health.
Status: UNKNOWN
Conditions: Mental Health Issue|Physical Inactivity
Interventions: OTHER: 26 styles of Chen Taichi training based on Relaxation guidelines|OTHER: 26 styles of Chen Taichi training based on Coordination guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Investigate the Efficacy and Tolerability of AZD1446 in Adult ADHD Patients.
Status: COMPLETED
Conditions: Adult ADHD
Interventions: DRUG: AZD1446|DRUG: AZD1446|DRUG: AZD1446|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effect of Oxytocin Receptor Modulation
Status: COMPLETED
Conditions: Pain|Hyperalgesia|Central Sensitization
Interventions: DRUG: Carbetocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Talquetamab and Teclistamab Each in Combination With a Programmed Cell Death Receptor-1 (PD-1) Inhibitor for the Treatment of Participants With Relapsed or Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed/ Refractory Multiple Myeloma
Interventions: DRUG: Talquetamab|DRUG: Teclistamab|DRUG: PD-1 Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Peptide Cancer Vaccine To Treat HLA-A*24-positive Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: BIOLOGICAL: HLA-A*2402restricted URLC10, CDCA1, and KIF20A peptides
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of the BRAF Inhibitor, Vemurafenib, Plus Obinutuzumab in Patients With Previously Untreated Classical Hairy Cell Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Hairy Cell Leukemia|Leukemia|Leukemia, Hairy Cell
Interventions: DRUG: Vemurafenib|DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab Followed by Chemotherapy for the Treatment of Patients With Classical Hodgkin Lymphoma
Status: RECRUITING
Conditions: Classic Hodgkin Lymphoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Dacarbazine|DRUG: Doxorubicin|PROCEDURE: Echocardiography|PROCEDURE: Multigated Acquisition Scan|BIOLOGICAL: Pembrolizumab|PROCEDURE: Positron Emission Tomography|DRUG: Vinblastine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methotrexate, Mannitol, Rituximab, and Carboplatin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma
Status: UNKNOWN
Conditions: Central Nervous System Lymphoma
Interventions: DRUG: Carboplatin|DRUG: Mannitol|DRUG: Methotrexate|OTHER: Quality-of-Life Assessment|BIOLOGICAL: Rituximab|DRUG: Sodium Thiosulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Calm in Arab Elderly With Dementia
Status: ENROLLING_BY_INVITATION
Conditions: Dementia|Agitation in Dementia, Including Alzheimer's Disease
Interventions: BEHAVIORAL: Integrated Snoezelen-Aromatherapy-Personal Item Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Amylin and CGRP Head to Head Provocation in Migraine Without Aura Patients
Status: COMPLETED
Conditions: Migraine Without Aura
Interventions: OTHER: Amylin (Pramlintide)|OTHER: CGRP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Magnesium, Vitamin B2, Feverfew, Andrographis Paniculata and Coenzyme Q10 for Episodic Migraine Prophylaxis
Status: COMPLETED
Conditions: Migraine
Interventions: DIETARY_SUPPLEMENT: magnesium, vitamin B2, feverfew, andrographis paniculata and coenzyme Q10
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p