pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Treadmill Cardiovascular Safety Study of Erenumab (AMG 334)
Status: COMPLETED
Conditions: Stable Angina
Interventions: DRUG: Erenumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Fluticasone Propionate Multidose Dry Powder Inhaler Compared With Fluticasone Propionate/Salmeterol Multidose Dry Powder Inhaler
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone Propionate|DRUG: Fluticasone Propionate/Salmeterol|DRUG: Placebo MDPI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tocilizumab vs Azathioprine in Neuromyelitis Optica Spectrum Disorders
Status: COMPLETED
Conditions: Neuromyelitis Optica Spectrum Disorders|Neuromyelitis Optica
Interventions: DRUG: Tocilizumab Injection|DRUG: Azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Anastomosis Sleeve Ileal Bypass Versus Single Anastomosis Sleeve Jejunal Bypass
Status: COMPLETED
Conditions: Obesity, Morbid
Interventions: PROCEDURE: SASI|PROCEDURE: SAS-J
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extended Culture of Day 3 to Day 5 Frozen Thawed Day 3 Embryos Versus Day 5 Frozen-Thawed Embryos
Status: COMPLETED
Conditions: Female Infertility
Interventions: OTHER: Extended culture for Group 2: (day 3-5 group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study Evaluating a Urinary Catheter With Different Activation Times for the Wetting Solution, in Healthy Male Volunteers.
Status: COMPLETED
Conditions: Urinary Catheterization
Interventions: DEVICE: Reference catheter: LoFric PVC, Nelaton 40 cm, CH 12|DEVICE: LoFric POBE Hydro-Kit II, 5 seconds|DEVICE: LoFric POBE Hydro-Kit II, 24 hours
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Pertuzumab, Trastuzumab, and Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With HER2-Positive Advanced Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: HER2-positive Breast Cancer|Recurrent Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer|Breast Adenocarcinoma|Inflammatory Breast Carcinoma
Interventions: BIOLOGICAL: pertuzumab|BIOLOGICAL: trastuzumab|DRUG: paclitaxel albumin-stabilized nanoparticle formulation|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhanced Community First Responder System Evaluation in Singapore
Status: NOT_YET_RECRUITING
Conditions: Out-Of-Hospital Cardiac Arrest
Interventions: DEVICE: CPRCard + TCPR Link App and Web|DEVICE: CPRCard Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase II Trial of a Chemotherapy Alone Regimen of IV Busulfan (Busulfex), Melphalan and Fludarabine as Myeloablative Regimen Followed by an Allogeneic T-Cell Depleted Hematopoietic Stem Cell Transplant From an HLA-Identical, or HLA-Non Identical Related or Unrelated Donor
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndrome|Non-Hodgkin's Lymphoma|Allogeneic Marrow Transplant
Interventions: DRUG: BUSULFAN, MELPHALAN, FLUDARABINE, G-CSF|DRUG: BUSULFAN, MELPHALAN, FLUDARABINE, G-CSF|DRUG: BUSULFAN, MELPHALAN, FLUDARABINE, G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atrial Fibrillation Trial to Evade Recurrence: effectS of Hiit Before electrO-Cardioversion for 3-weeKs
Status: TERMINATED
Conditions: Persistent Atrial Fibrillation
Interventions: BEHAVIORAL: High-intensity interval training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Comparison of Subject-administered Romosozumab With Healthcare Provider-administered Romosozumab for Osteoporosis
Status: COMPLETED
Conditions: Post-Menopausal Osteoporosis
Interventions: DRUG: romosozumab HCP administration with PFS|DEVICE: romosozumab self-administration with AI/Pen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Physiotherapy, Mandibular Motion and Sensorial Recovery After Orthognathic Surgery
Status: UNKNOWN
Conditions: Mandibular Range of Motion|Pain|Sensorial Disturbance
Interventions: OTHER: Early Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Iron Versus Oral Iron for Severe Postpartum Anemia
Status: COMPLETED
Conditions: Anemia|Puerperal Disorders
Interventions: DRUG: Iron sucrose|DRUG: NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Entolimod on Immunosenescence in Healthy Geriatric Subjects Receiving Influenza Vaccination
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Entolimod|DRUG: Placebo|DRUG: Influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Sodium Selenite and Radiation Therapy in Treating Patients With Metastatic Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Prostate|Hormone-resistant Prostate Cancer|Recurrent Prostate Cancer|Stage IV Prostate Cancer|Multiple Myeloma|Plasmacytoma
Interventions: DRUG: sodium selenite|RADIATION: radiation therapy|OTHER: laboratory biomarker analysis|OTHER: pharmacological study|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Oral Weekly GS-1720 and GS-4182 Versus Biktarvy in People With HIV-1 Who Are Virologically Suppressed
Status: RECRUITING
Conditions: HIV-1-Infection
Interventions: DRUG: GS-1720|DRUG: GS-4182|DRUG: Placebo to Match BVY|DRUG: Bictegravir/emtricitabine/tenofovir alafenamide|DRUG: GS-1720/GS-4182 FDC|DRUG: Placebo to Match GS1720/GS-4182 FDC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Effects of Sound Modulation on Critically Ill Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Critical Illness|Physiological Stress|Delirium|Sleep Deprivation
Interventions: DEVICE: Sound reduction|DEVICE: Sound masking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tirofiban for Patients Treated With Alteplase
Status: TERMINATED
Conditions: Ischemic Stroke
Interventions: DRUG: Tirofiban|DRUG: Alteplase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety and Tolerability of Single and Repeat Doses of PC786
Status: COMPLETED
Conditions: Respiratory Syncytial Virus (RSV)
Interventions: DRUG: PC786 - Single doses|DRUG: Placebo - Single doses|DRUG: PC786 - Repeat doses|DRUG: Placebo - Repeat doses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cetuximab and Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: cetuximab|RADIATION: 3-dimensional conformal radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spine FA3 - a Prospective, International, Multicenter Cohort Study on Treatment of of AO A3 Thoracolumbar Fractures
Status: TERMINATED
Conditions: Single Level Stable Thoracolumbar Fracture Type AO A3|Multiple Level Stable Thoracolumbar Fracture Type AO A3
Interventions: PROCEDURE: Surgical|PROCEDURE: Conservative treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comparison of mNT-BBAVF and BCAVF in Hemodialysis Patients
Status: COMPLETED
Conditions: Vascular Fistula
Interventions: PROCEDURE: mNT-BBAVF|PROCEDURE: BCAVF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Silver Diamine Fluoride as a Treatment for Caries in Comparison to Traditional Restorative Techniques
Status: COMPLETED
Conditions: Caries
Interventions: DEVICE: Silver Diamine Fluoride|PROCEDURE: Conventional Caries Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: H5 Adult - Chiron Study of Bird Flu Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Aluminum hydroxide|BIOLOGICAL: Inactivated Influenza A/H5N1 Vaccine (Chiron)|BIOLOGICAL: MF-59|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Topical Cyclosporine-A for Management of Epiphora
Status: COMPLETED
Conditions: Epiphora
Interventions: DRUG: topical 0.05% CsA (Restasis®, Allergan Inc, Irvine, California)twice daily dose,
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRI Assessment of Myocardial Fibrosis Associated With Monocyte Phenotype in End Stage Renal Failure
Status: WITHDRAWN
Conditions: Myocardial Fibrosis|End Stage Renal Failure on Dialysis|Chronic Kidney Disease, Stage IV (Severe)|Chronic Kidney Disease Stage V|Heart Failure
Interventions: DIAGNOSTIC_TEST: Cardiac MRI 1 - With Gadolinium Contrast|DIAGNOSTIC_TEST: Cardiac MRI 2 - With Gadolinium Contrast|DIAGNOSTIC_TEST: Cardiac MRI 3 - Without Gadolinium Contrast|DIAGNOSTIC_TEST: Cardiac MRI 3 - With Gadolinium Contrast|DIAGNOSTIC_TEST: Peripheral Whole Blood Samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use of a Novel Diet (UC DIET) for Treatment of Mild to Moderate Active Pediatric Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis (UC)
Interventions: OTHER: Ulcerative Colitis Diet|DRUG: Antibiotic cocktail
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EUROPAC-2 - Pain Treatment of Hereditary and Idiopathic Pancreatitis
Status: COMPLETED
Conditions: Pancreatitis
Interventions: DIETARY_SUPPLEMENT: ANTOX (vers.)1.2|DRUG: Magnesium|OTHER: Placebo ANTOX (vers)1.2|OTHER: Placebo Magnesiocard (2.5 mmol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Omeprazole and Fluvoxamine on Platelet Response to Clopidogrel
Status: COMPLETED
Conditions: Drug Interaction of Clopidogrel
Interventions: DRUG: omeprazole|DRUG: fluvoxamine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Gefapixant (MK-7264) in Acute Cough for Participants With Induced Viral Upper Respiratory Tract Infection (URTI) (MK-7264-013)
Status: TERMINATED
Conditions: Acute Cough
Interventions: DRUG: Gefapixant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Chronic Acid-Base Changes on Ventilatory and Perceptual Responses
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: NH4Cl (ammonium chloride)|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tongyuan Acupuncture on Consciousness Disorder After Stroke
Status: RECRUITING
Conditions: Stroke
Interventions: DEVICE: Acupuncture with regulating immunity as the core of treatment|DEVICE: Needles that are not on acupoints
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Lutein Supplementation on Subclinical Atherosclerosis
Status: COMPLETED
Conditions: Carotid Atherosclerosis|Carotid Intimal Medial Thickness 1
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Lutein group|DIETARY_SUPPLEMENT: Combination group|DIETARY_SUPPLEMENT: Normal lutein control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Middle-Ear Implant With MET V Transducer (Aka MET V System)
Status: UNKNOWN
Conditions: Mixed Conductive and Sensorineural Hearing Loss, Bilateral
Interventions: DEVICE: Middle Ear Implant with MET V Transducer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surufatinib Alone or Combined With Anti-PD-1 mAb in the Treatment of Advanced Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma; Targeted Therapy; Progression-free Survival
Interventions: DRUG: Surufatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-modulation of the Sense of Agency by Means of Real-time Neurofeedback
Status: RECRUITING
Conditions: Psychogenic Seizure|Epilepsy, Temporal Lobe|Health, Subjective
Interventions: BEHAVIORAL: Real Neurofeedback|BEHAVIORAL: Sham Neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: DAILIES TOTAL1® Lens Centration in a Japanese Population
Status: COMPLETED
Conditions: Myopia|Refractive Error
Interventions: DEVICE: Delefilcon A contact lenses|DEVICE: Narafilcon A contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Vactosertib and Imatinib Combination in Patients With Advanced Desmoid Tumor/Aggressive Fibromatosis (DT/AF)
Status: RECRUITING
Conditions: Dermoid
Interventions: DRUG: Vactosertib|DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Levobupivacaine, Ropivacaine and Bupivacaine in Epidural Anaesthesia
Status: COMPLETED
Conditions: Pain Insensitivity, Congenital
Interventions: DRUG: Bupivacaine|DRUG: Levobupivacaine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Airway Pressure Release Ventilation (APRV) Versus AC/VC Conventional Ventilation
Status: UNKNOWN
Conditions: Respiratory Failure|Acute Lung Injury (ALI)|Acute Respiratory Distress Syndrome (ARDS)
Interventions: DEVICE: Mechanical Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Tolerability, Safety, and Pharmacokinetics of ISU302 in Healthy Volunteers
Status: COMPLETED
Conditions: Gaucher Disease
Interventions: DRUG: ISU302|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Pilot Study of a 14-day Modified Sequential Therapy for Helicobacter Pylori Infection
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: esomeprazole, amoxicillin, tetracycline, furazolidone (only for the first 7 days), colloidal bismuth pectin (for the second 7 days)|DRUG: rabeprazole, amoxicillin, tetracycline, furazolidone (only for the first 7 days), colloidal bismuth pectin (for the second 7 days)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Real-time Binaural Sound on Sedation Using Dexmedetomidine
Status: COMPLETED
Conditions: Sedative Adverse Reaction
Interventions: PROCEDURE: Real-time binaural sound|PROCEDURE: Music|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Common Neonatal Procedures Could Affect the aEEG in <30 Weeks of Gestational Age Preterms
Status: UNKNOWN
Conditions: Regional Blood Flow|Premature Birth|Electroencephalography
Interventions: DRUG: 3 protocols of Indomethacin administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Novel Imaging Markers in SPMS
Status: COMPLETED
Conditions: Secondary Progressive Multiple Sclerosis|Multiple Sclerosis, Secondary Progressive|Multiple Sclerosis
Interventions: DRUG: Ferumoxytol infusion|DRUG: Gadoteridol|DIAGNOSTIC_TEST: MRI Brain and Cervical Spine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: An Open-label Comparative Efficacy and Safety Study of Algeron (Cepeginterferon Alfa-2b) in Treatment-naive Patients With Chronic Hepatitis C
Status: COMPLETED
Conditions: Hepatitis|Hepatitis C
Interventions: DRUG: Algeron|DRUG: Pegasys
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobilization and Collection of Peripheral Blood Stem Cells in Patients With Fanconi Anemia Using G-CSF and Plerixafor
Status: COMPLETED
Conditions: Fanconi Anemia
Interventions: DRUG: G-CSF|DRUG: Plerixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Bivalirudin Versus Heparin During Coil Embolization in Patients With Ruptured Intracranial Aneurysms
Status: UNKNOWN
Conditions: Subarachnoid Hemorrhage, Aneurysmal
Interventions: DRUG: Bivalirudin 250 MG Injection|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Antipsychotic Polypharmacy in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: 2 antipsychotic medications (combinations of olanzapine, risperidone, clozapine, seroquel, haldol, perphenazine)|DRUG: main antipsychotic medication and placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: tDCS With Cognitive Training to Reduce Impulsivity and Weight in Veterans With Obesity
Status: RECRUITING
Conditions: Obesity
Interventions: DEVICE: Sham Transcranial Direct Current Stimulation (tDCS)|DEVICE: Active Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Augmenting Virtual Reality Exposure Therapy for Acrophobia
Status: SUSPENDED
Conditions: Specific Phobia|Anxiety Disorders|Fear of Heights|Acrophobia
Interventions: BEHAVIORAL: Virtual Reality Exposure Therapy|BEHAVIORAL: Tactile Feedback|BEHAVIORAL: Point-based Rewards
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of AK101 in Subjects With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: BIOLOGICAL: AK101|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Zoledronic Acid in Combination With Interleukin-2 to Expand Vγ9Vδ2 T Cells After T-replete Haplo-identical Allotransplant
Status: COMPLETED
Conditions: Hematopoietic Stem Cell Transplantation
Interventions: DRUG: IL2|DRUG: Zoledronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of the Puncture of the RP6 Point on the Ampliation and Injuries of the Perineum During Childbirth
Status: COMPLETED
Conditions: Perineum; Injury
Interventions: OTHER: Puncture of the RP6 point|OTHER: Puncture of the placebo point
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Ribociclib&Belinostat In Patients w Metastatic Triple Neg Breast Cancer & Recurrent Ovarian Cancer w Response Prediction By Genomics
Status: RECRUITING
Conditions: Metastatic Breast Cancer|Recurrent Ovarian Carcinoma
Interventions: DRUG: Ribociclib|DRUG: Belinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fixation of the Orogastric Tube: Which Method for the Newborn ?
Status: UNKNOWN
Conditions: Enteral Feeding|Gastric Emptying
Interventions: DEVICE: method of fixation of the orogastric tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess Adverse Events and Effectiveness of Intradermally Injected JUVÉDERM® VOLITE™ Gel Filler in Adult Participants in China With Fine Lines Around the Mouth
Status: ACTIVE_NOT_RECRUITING
Conditions: Perioral Lines
Interventions: DEVICE: JUVÉDERM® VOLITE™|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Correlation Between Sulcus Anatomy and Other Parameters After Horizontal & Vertical Intraocular Lens (IOLs) Placements
Status: COMPLETED
Conditions: Cataract|Pseudophakia
Interventions: PROCEDURE: Horizontal placement of the intraocular lens in the capsular bag|PROCEDURE: Vertical placement of the intraocular lens in the capsular bag
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Efficacy of Micronutrient Fortified Yoghurt in School Children for Health Benefits
Status: UNKNOWN
Conditions: Child Development|Cognitive Development|Morbidity|Physical Growth
Interventions: DIETARY_SUPPLEMENT: Fortified Yoghurt|DIETARY_SUPPLEMENT: Yoghurt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Functional Recovery in Stroke Patients With Task-Specific Robot-Aided Arm Therapy
Status: COMPLETED
Conditions: Stroke|Upper Extremity Paresis
Interventions: DEVICE: robot therapy (ARMin)|OTHER: conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Cold Saline Used to Inflate a Balloon Tamponade Catheter More Significantly Reduce Blood Loss From Postpartum Hemorrhage Than Room Temperature Saline?
Status: UNKNOWN
Conditions: Postpartum Hemorrhage
Interventions: DEVICE: Cold Bakri Balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Xihuang Capsules Prevention of Recurrence in Patients With Hepatocellular Carcinoma After Hepatectomy
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Xihuang Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Alcohol Early Intervention for Freshmen
Status: UNKNOWN
Conditions: Alcohol Abuse
Interventions: BEHAVIORAL: Brief Motivational Intervention (BMI)|BEHAVIORAL: Parent Based Intervention plus booster|BEHAVIORAL: Combined brief motivational intervention and parent based intervention plus boosters for both interventions|OTHER: Assessment only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Repeat Administration of Ad/PNP and Fludarabine Phosphate in Patients With Local Head/Neck Cancer
Status: RECRUITING
Conditions: Recurrent Head and Neck Cancer
Interventions: BIOLOGICAL: Ad/PNP|DRUG: Fludarabine Phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy and Safety of Casirivimab+Imdevimab (Monoclonal Antibodies) for Prevention of COVID-19 in Immunocompromised Adolescents and Adults
Status: TERMINATED
Conditions: Immunocompromised
Interventions: DRUG: casirivimab+imdevimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Irbesartan and Atorvastatin in Hypertension and Hyperlipidemia
Status: COMPLETED
Conditions: Hypertension|Hyperlipidemia
Interventions: DRUG: Irbesartan/Atorvastatin A|DRUG: Irbesartan|DRUG: Atorvastatin A|DRUG: Placebo|DRUG: Irbesartan/Atorvastatin B|DRUG: Atorvastatin B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Combination of Ginkgo Extract and Ginseng Extract(YY-162)in Children With ADHD
Status: COMPLETED
Conditions: Mental Disorders
Interventions: DRUG: YY-162|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Factorial Optimization Trial to Test Effects of Coping Intervention Components
Status: RECRUITING
Conditions: Anxiety|Depression|Coping Skills|Emotional Problem
Interventions: BEHAVIORAL: Education|BEHAVIORAL: Reappraisal Coping|BEHAVIORAL: Distraction Coping|BEHAVIORAL: Relaxation Coping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Somatuline Autogel Preference and Health Economy Study
Status: COMPLETED
Conditions: Neuroendocrine Tumour With Carcinoid Symptoms
Interventions: DRUG: lanreotide (Autogel formulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Duration of Antibiotic Therapy on Recovery Following Tonsillectomy
Status: COMPLETED
Conditions: Tonsillectomy
Interventions: DRUG: 7 days of amoxicillin|DRUG: 3 days of amoxcillin followed by 4 days of placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Lateral Neck Lymph Node Mapping in Thyroid Cancer
Status: UNKNOWN
Conditions: Thyroid Cancer
Interventions: PROCEDURE: Lateral neck sentinel lymph node biopsy|PROCEDURE: Modified lateral neck lymph node dissection|PROCEDURE: Super selective lateral neck lymph node dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: ENMS With Balance Feedback for Post-stroke Ankle-foot Rehabilitation
Status: RECRUITING
Conditions: Cerebrovascular Stroke|Foot Drop|Foot Inversion Deformity
Interventions: DEVICE: ENMS-BSF assisted gait training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cold or Hot Snare Endoscopic Mucosal Resection for 10-19mm Non-pedunculated Colorectal Polyps
Status: RECRUITING
Conditions: Colorectal Polyp
Interventions: PROCEDURE: Cold snare endoscopic mucosal resection|PROCEDURE: Hot snare endoscopic mucosal resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two Doses of the Intravenous Magnesium Sulfate Versus the Standard Single Dose ,With/ Without the Nebulized Budesonide For the Management of the Severe Asthma Exacerbation in the Emergency Room; A Randomized Controlled Trial.
Status: RECRUITING
Conditions: Bronchial Asthma
Interventions: DRUG: Hi-dose iv MgSO4|DRUG: Nebulized budesonide|DRUG: Std-dose iv MgSO4|DRUG: Nebulized normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: In Vitro Organoid Drug Sensitivity-Guided Treatment for Metastatic Pancreatic and Gastric Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer|Gastric Cancer
Interventions: PROCEDURE: Biopsy of tumor tissue for organoid culture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subcutaneous Velcade Plus Oral Melphalan and Prednisone or Plus Cycloposphamide and Prednisone or Plus Prednisone
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: velcade subcutaneous melphalan prednisone|DRUG: velcade cyclophosphamide prednisone|DRUG: velcade prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Obeticholic Acid in the Treatment of Primary Biliary Cholangitis
Status: COMPLETED
Conditions: Primary Biliary Cholangitis
Interventions: DRUG: Obeticholic Acid Tablets（OCA）|DRUG: UDCA|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Bemcentinib Plus Pacritinib In Patients With Advanced Lung Adenocarcinoma
Status: NOT_YET_RECRUITING
Conditions: Advanced Lung Adenocarcinoma
Interventions: DRUG: bemcentinib|DRUG: pacritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Xylitol Use for Decolonization of C. Difficile in Patients With IBD
Status: NOT_YET_RECRUITING
Conditions: Inflammatory Bowel Diseases|Clostridioides Difficile Infection
Interventions: DRUG: Xylitol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sequential PD-1/PD-L1 Inhibitor and LENvatinib in TLCT and Refractory Hepatoblastoma After Chemotherapy
Status: UNKNOWN
Conditions: Transitional Cell Tumor|Hepatoblastoma|Liver Cancer|Pediatric Solid Tumor|Pediatric Cancer
Interventions: DRUG: PD-1 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DAW1033D in Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea (OSA)
Interventions: DRUG: Placebo oral capsule|DRUG: DAW1033D oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brain-Computer Interface System for Training Memory and Attention in Elderly
Status: COMPLETED
Conditions: Alzheimer's Disease|Mild Cognitive Impairment|Age-Related Cognitive Decline|Dementia
Interventions: DEVICE: Brain-Computer Interface
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Humanized CD19-Specific CAR T Cells for the Treatment of Patients With Positive Relapsed or Refractory CD19 Positive B-Cell Acute Lymphoblastic Leukemia
Status: RECRUITING
Conditions: Recurrent Acute Lymphoblastic Leukemia|Refractory Acute Lymphoblastic Leukemia
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|BIOLOGICAL: CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes|BIOLOGICAL: Cetuximab|PROCEDURE: Computed Tomography|DRUG: Cyclophosphamide|PROCEDURE: Echocardiography|DRUG: Fludarabine|PROCEDURE: Leukapheresis|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Multigated Acquisition Scan|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hysterectomy for Benign Gynaecological Conditions With or Without Tubectomy
Status: COMPLETED
Conditions: Abdominal Hysterectomy (& Wertheim)
Interventions: PROCEDURE: Hysterectomy plus Tubectomy|PROCEDURE: Hysterectomy|DEVICE: light microscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dose Escalation Study to Investigate Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BAY85-3934 in Subjects With Chronic Kidney Disease (CKD)
Status: COMPLETED
Conditions: Kidney Diseases
Interventions: DRUG: Molidustat (BAY85-3934)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: A Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacology of ONO-4474 in Healthy Volunteers
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: ONO-4474 Part A1|DRUG: Placebo Part A1|DRUG: ONO-4474 Part A2|DRUG: Placebo Part A2|DRUG: ONO-4474 Part B|DRUG: Placebo Part B|DRUG: ONO-4474 Part C|DRUG: Placebo Part C|DRUG: ONO-4474 Part D|DRUG: Placebo Part D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of Imovax Polio in Chinese Infants Compared to Local OPV
Status: COMPLETED
Conditions: Poliomyelitis|Polio
Interventions: BIOLOGICAL: Poliomyelitis Vaccine inactivated|BIOLOGICAL: Poliomyelitis Vaccine in Dragee Candy (Human Diploid Cell)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study Assessing Patient Handling of Flutiform® Breath-Actuated Inhaler (BAI) and Flutiform® Pressurised Metered Dose Inhaler (pMDI)
Status: COMPLETED
Conditions: Asthma|COPD
Interventions: DEVICE: Flutiform® pMDI and Breath Actuated Inhaler (BAI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Anti Bacterial Effect of Titanium Dioxide Nanoparticles on Baseplates of Twin Block
Status: COMPLETED
Conditions: Gingival Inflammation
Interventions: OTHER: titanium dioxide nanoparticles in test group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: a Bayesian Analysis of Three Randomised Clinical Trials of Intraoperative Ventilation
Status: ACTIVE_NOT_RECRUITING
Conditions: Mechanical Ventilation Complication|Surgery|Pulmonary Complication|Postoperative Complications
Interventions: OTHER: High PEEP + Recruitment maneuvers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cardiovascular Disease Education and Problem-Solving Training in People With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Education + Problem-Solving Training Self-Study|BEHAVIORAL: Education + Group Problem-Solving Training|BEHAVIORAL: Education + Individual Problem-Solving Training|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Primary Teeth Anesthesia Using Nasal Spray in Children
Status: COMPLETED
Conditions: Dental Caries
Interventions: DRUG: Nasal Spray of Lidocaine HCL|DRUG: Infiltration injection of Lidocaine HCL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dexmedetomidine on the Renal Functions in Septic Critically Ill Patients
Status: NOT_YET_RECRUITING
Conditions: Sepsis|Septic Shock|Acute Kidney Injury
Interventions: DRUG: Dexmedetomidine|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Basket Study of Customized Autologous TCR-T Cell Therapies in Patients With Locally Advanced (Unresectable) or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Head and Neck Cancer|Cervical Cancer|Non-small Cell Carcinoma|Melanoma|Ovarian Cancer|Anogenital Cancers|HPV - Anogenital Human Papilloma Virus Infection|HPV-Related Cervical Carcinoma|HPV-Related Carcinoma|HPV-Related Squamous Cell Carcinoma|HPV-Related Malignancy|HPV-Related Adenocarcinoma|HPV Positive Oropharyngeal Squamous Cell Carcinoma|HPV-Related Adenosquamous Carcinoma|HPV-Associated Vaginal Adenocarcinoma|HPV-Related Endocervical Adenocarcinoma|HPV-Related Anal Squamous Cell Carcinoma|HPV-Related Verrucous Carcinoma|HPV-Related Penile Squamous Cell Carcinoma|HPV-Related Vulvar Squamous Cell Carcinoma|HPV Positive Rectal Squamous Cell Carcinoma
Interventions: BIOLOGICAL: TSC-204-A0201|BIOLOGICAL: TSC-204-C0702|BIOLOGICAL: TSC-200-A0201|BIOLOGICAL: TSC-204-A0201 + TSC-204-C0702|BIOLOGICAL: TSC-204-A0201 + TSC-200-A0201|BIOLOGICAL: TSC-204-C0702 + TSC-200-A0201|BIOLOGICAL: TSC-204-A0201 + TSC-203-A0201|BIOLOGICAL: TSC-204-C0702 + TSC-203-A0201|BIOLOGICAL: TSC-200-A0201 + TSC-203-A0201|BIOLOGICAL: TSC-203-A0201|BIOLOGICAL: TSC-204-A0101|BIOLOGICAL: TSC-201-B0702|BIOLOGICAL: TSC-204-A0201 + TSC-204-A0101|BIOLOGICAL: TSC-204-A0201 + TSC-201-B0702|BIOLOGICAL: TSC-204-C0702 + TSC-204-A0101|BIOLOGICAL: TSC-204-C0702 + TSC-201-B0702|BIOLOGICAL: TSC-200-A0201 + TSC-204-A0101|BIOLOGICAL: TSC-200-A0201 + TSC-201-B0702|BIOLOGICAL: TSC-203-A0201 + TSC-204-A0101|BIOLOGICAL: TSC-203-A0201 + TSC-201-B0702
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Empagliflozin on the Function of Left Atrium in Heart Failure With Mildly Reduced or Preserved Ejection Fraction
Status: ENROLLING_BY_INVITATION
Conditions: Heart Failure|Heart Failure With Preserved Ejection Fraction|Heart Failure With Mid Range Ejection Fraction
Interventions: DRUG: Empagliflozin 10 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers and Clinical Features of Metastatic Breast Cancer in Patients Treated With CDK4/6 Inhibitors
Status: RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Breast Carcinoma|Prognostic Stage IV Breast Cancer AJCC v8
Interventions: OTHER: Cytology Specimen Collection Procedure|OTHER: Diagnostic Laboratory Biomarker Analysis|OTHER: Medical Chart Review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Northern-Manhattan Hispanic Caregiver Intervention Effectiveness Study
Status: COMPLETED
Conditions: Depressive Symptoms|Burden
Interventions: OTHER: Social work support|OTHER: Educational material|BEHAVIORAL: NYU caregiver counseling intervention|BEHAVIORAL: REACH OUT counseling intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics of Single Bolus Dose of NovoSeven® in Paediatric and Adult Patients With Haemophilia A or B in a Non- Bleeding State
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A|Haemophilia B
Interventions: DRUG: activated recombinant human factor VII|DRUG: activated recombinant human factor VII
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Durvalumab in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer
Status: WITHDRAWN
Conditions: Castration Levels of Testosterone|Hormone-Resistant Prostate Cancer|Microsatellite Instability
Interventions: BIOLOGICAL: Durvalumab|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of COP Exercise and HIIT on Vascular Health in Young Overweight Females
Status: COMPLETED
Conditions: Vascular Diseases
Interventions: BEHAVIORAL: high-intensity interval training (HIIT)|BEHAVIORAL: crossover point(COP) exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A 24-Week Study of Topical Pirenzepine or Placebo in Type 2 Diabetic Patients (T2DM) With Peripheral Neuropathy
Status: COMPLETED
Conditions: Peripheral Neuropathy|Painful Diabetic Neuropathy|Diabetic Neuropathies, Painful
Interventions: DRUG: WST-057 (4% pirenzepine) Lose Dose 2mL|DRUG: WST-057 (4% pirenzepine) High Dose 4mL|DRUG: Placebo Low Dose|DRUG: Placebo High Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Applicability of 3D Printing and 3D Digital Image Reconstruction in the Planning of Complex Liver Surgery (LIV3DPRINT).
Status: UNKNOWN
Conditions: Liver Diseases|Surgery
Interventions: DEVICE: 3D PRINTING
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Topical NVN1000 for the Treatment of External Genital and Perianal Warts
Status: COMPLETED
Conditions: Genital Warts|Perianal Warts
Interventions: DRUG: NVN1000 8% Gel|DRUG: NVN1000 16%|DRUG: Vehicle|DRUG: NVN1000 24%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Controlling Hypertension Outcomes by Improved Communication & Engagement
Status: COMPLETED
Conditions: Hypertension|Stroke
Interventions: OTHER: Informational Guide for Patients|BEHAVIORAL: Video-Assisted Coaching|OTHER: Monograph for Physicians|BEHAVIORAL: Educational Coaching|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Improving Laboratory Follow-up by Delivering an Enhanced Medication List to Outpatient Physician Practices
Status: COMPLETED
Conditions: Medication Histories in Outpatient Clinic Patients
Interventions: OTHER: Medication History was printed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Post Operative Analgesia and Patient Satisfaction
Status: COMPLETED
Conditions: Postoperative Pain|Patient Satisfaction|Analgesia
Interventions: DRUG: Hydrocodone/Acetaminophen 5 Mg-325 Mg ORAL TABLET|DRUG: Ibuprofen 600 mg|DRUG: Acetaminophen 650 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Added Enzyme α-Galactosidase at a Carbohydrate-rich Meal in Irritable Bowel Syndrome (IBS)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Alpha-Galactosidase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Selinexor Plus DRd for Newly Diagnosed Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma|Myeloma Multiple|Kahler Disease|Myeloma, Plasma Cell|Myeloma-Multiple|Myelomatosis|Plasma Cell Myeloma
Interventions: DRUG: Selinexor|DRUG: Dexamethasone Oral|DRUG: Daratumumab|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Newly Designed Vaginal Stent to Improve Patient Comfort and Healing Following Vaginal Surgery or Vaginal Radiation
Status: TERMINATED
Conditions: Vaginal Stricture
Interventions: DEVICE: Vaginal Stent A|DEVICE: Vaginal Stent B|DEVICE: Vaginal Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical and Radiographic Assessment After Surgical Treatment of Anterior Shoulder Dislocation
Status: RECRUITING
Conditions: Anterior Shoulder Dislocation|Bone Defects|Shoulder Instability
Interventions: PROCEDURE: allograft fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT