pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: POPLITEAL SCIATIC NERVE BLOCK FOR DIABETIC FOOT SURGERIES
Status: UNKNOWN
Conditions: Diabetic Patient
Interventions: DRUG: bupivacaine|DRUG: magnesium sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial on a Group Treatment for Distressed Caregivers of Cancer Patients
Status: WITHDRAWN
Conditions: Distress in Caregivers of Cancer Patients
Interventions: BEHAVIORAL: Tailored group intervention (PREPARE)|BEHAVIORAL: Individual treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dual Task and Virtuality Training Innovation to Improve Balance, Posture and Gait in Patients With Parkinson Disease
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: OTHER: Virtual reality intervention|OTHER: Dual task intervention|OTHER: Conventional physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Plant-based Diet for Kidney Transplant Recipients
Status: RECRUITING
Conditions: Kidney Disease, Chronic|Transplant Complication|Hypertension|Diabetes Mellitus|Metabolic Syndrome|Inflammation|Kidney Transplant Failure|Dietary Habits
Interventions: BEHAVIORAL: Plant-based diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib and Doxil for the Treatment of Patients With Acute Myelogenous Leukemia
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia
Interventions: DRUG: Bortezomib|DRUG: Doxil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Symptoms of Schizophrenia and Physical Exercise
Status: COMPLETED
Conditions: Schizophrenia
Interventions: OTHER: Resistance Training|OTHER: Concurrent Training|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel in Combination With Zactima (ZD6474) in Patients With Locally Advanced Squamous Cell Carcinoma of the the Head and Neck
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of Head and Neck
Interventions: DRUG: ZD6474|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II HDM-SPIRE Safety and Efficacy Study
Status: COMPLETED
Conditions: Rhinoconjunctivitis
Interventions: DRUG: HDM-SPIRE|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Canaloplasty and Non-penetrating Deep Sclerectomy With Phacoemulsification to Treat Glaucoma and Cataract
Status: UNKNOWN
Conditions: Open Angle Glaucoma|Cataract
Interventions: PROCEDURE: Canaloplasty and phacoemulsification|PROCEDURE: Non-penetrating deep sclerectomy and phacoemulsification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Blood Coagulation Disorders in Patients With Pulmonary Hypertension
Status: UNKNOWN
Conditions: Pulmonary Artery Hypertension|Chronic Thromboembolic Pulmonary Hypertension
Interventions: DIAGNOSTIC_TEST: Platelet function analyzer-100|DIAGNOSTIC_TEST: Light transmission aggregometry|DIAGNOSTIC_TEST: Rotational thromboelastometry|DIAGNOSTIC_TEST: Endogenous thrombin potential
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Electric Ride-On Cars Use During Transport to the Operating Theatre
Status: COMPLETED
Conditions: Anxiety|Preoperative Anxiety|Pediatric Surgery
Interventions: OTHER: Transfer with an electric ride-on car
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Alternatives for Reducing Tics in Tourette Syndrome (TS): A Study of TEV-50717 (Deutetrabenazine) for the Treatment of Tourette Syndrome in Children and Adolescents
Status: COMPLETED
Conditions: Tourette Syndrome
Interventions: DRUG: TEV-50717|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Investigate the Pharmacokinetic Profiles and Safety of CKD-333 in Healthy Volunteers
Status: COMPLETED
Conditions: Hypertension|Dyslipidemias
Interventions: DRUG: CKD-330 16/10mg Tab. 1T and D086 Tab. 1T|DRUG: CKD-333 16/10/40mg formulation 1 Tab. 1T|DRUG: CKD-333 16/10/40mg formulation 2 Tab. 1T
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Staphylococcus and Neisseria Tablets in the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease.
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: High dose or normal dose staphylococcus albicans|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine for Prevention of Postoperative Delirium After Intracranial Operation for Brain Tumor
Status: UNKNOWN
Conditions: Central Nervous System Diseases
Interventions: DRUG: Dexmedetomidine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Nutritional Counselling and "Improved Atta" Supplementation in Cachexic Adult Indian Cancer Patients
Status: COMPLETED
Conditions: Cachexia|Cancer
Interventions: DIETARY_SUPPLEMENT: Improved Atta|DIETARY_SUPPLEMENT: Wheat flour|BEHAVIORAL: Physical activity counseling|OTHER: Nutritional counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Atorvastatin Study For The Treatment Of High Cholesterol In Patients From Thailand
Status: COMPLETED
Conditions: Dyslipidemias
Interventions: DRUG: Atorvastatin|DRUG: Atorvastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-omics Study of Adenomyosis
Status: UNKNOWN
Conditions: Adenomyosis|Endometriosis|Ectopic Endometrium|Eutopic Endometrium|Genomics|Transcriptomics|Metabolomics
Interventions: COMBINATION_PRODUCT: A multi-omics analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of BDC-1001 +/- Pertuzumab in Subjects With HER2-Positive Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Breast Cancer|HER2-positive Breast Cancer
Interventions: DRUG: BDC-1001|DRUG: Pertuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wavefront Analisys and Contrast Sensitivity of Spherical and Aspherical Intraocular Lenses
Status: COMPLETED
Conditions: Cataract|Pseudophakia
Interventions: PROCEDURE: phacoemulsification (cataract surgery)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Health Without Barriers/Salud Sin Barreras
Status: RECRUITING
Conditions: Mental Health Wellness|Family Research|Lifestyle Risk Reduction
Interventions: BEHAVIORAL: Mindfulness-Based Intervention|BEHAVIORAL: Parent Education|BEHAVIORAL: Physical Activity|BEHAVIORAL: Brief Mindfulness Intervention for Parents|BEHAVIORAL: Preschool Curriculum|BEHAVIORAL: Cooking Matters
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cetuximab Plus Dalpicilib in Patients With HPV Negative, PD-1 Resistant R/M HNSCC
Status: RECRUITING
Conditions: Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Dalpiciclib+cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Video Games Among People With Schizophrenia
Status: COMPLETED
Conditions: Cognitive Function|Schizophrenia and Disorders With Psychotic Features
Interventions: BEHAVIORAL: Cognifit|BEHAVIORAL: SIMS 4 (Maxis, Inc)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Timing of Damage Control Orthopedic Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: The Precision Personal Timeline in Definitive Surgery Associated With Outcome
Interventions: PROCEDURE: Utilizing dry lab database to analyze the prognostic factors of multi-trauma patients and determine the optimal timing of definitive orthopedic operation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Study to Assess the Pharmacokinetics, Safety and Tolerability of Single and Multiple Oral Doses of AFQ056 in Children With Fragile X Syndrome (FXS)
Status: COMPLETED
Conditions: Fragile X Syndrome
Interventions: DRUG: AFQ056
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Microcurrent Dressing to Treat Infections, Before, During and After Surgery
Status: COMPLETED
Conditions: Shoulder Arthropathy Associated With Other Conditions|Shoulder Arthritis|Shoulder Osteoarthritis|Shoulder Pain
Interventions: DEVICE: Jumpstart Dressing|OTHER: Standard Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cerebellar TMS and Satiety in Prader-Willi Syndrome
Status: RECRUITING
Conditions: Prader-Willi Syndrome
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Valacyclovir in the Reduction of HSV-2 Recurrence and Shedding
Status: COMPLETED
Conditions: HIV|HIV Infections
Interventions: DRUG: Valacyclovir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Description of Socio-cognitive and Clinic Changes for Type 1 Diabetes Adolescents Cohort With Therapeutic Patient Education Program
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: OTHER: Questionnaires and audio-tape interviews
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neuromuscular Blockade During Transurethral Resection of Bladder Cancer
Status: COMPLETED
Conditions: Neuromuscular Blockade
Interventions: DRUG: Rocuronium|DRUG: Sugammadex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study Assessing the Safety, Tolerability, Immunogenicity of COVID-19 Vaccine Candidate PRIME-2-CoV_Beta, Orf Virus Expressing SARS-CoV_2 Spike and Nucleocapsid Proteins
Status: TERMINATED
Conditions: SARS-CoV-2 Infection
Interventions: DRUG: PRIME-2-CoV_Beta
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ventilatory Muscle Training in Stroke
Status: COMPLETED
Conditions: Stroke|Pulmonary Ventilation|Exercise Therapy
Interventions: BEHAVIORAL: IMT with High Resistance EMT|BEHAVIORAL: IMT with Low Resistance EMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single-arm Study of Symplicity™ Renal Denervation System in Patients With Uncontrolled HyperTensioN in India
Status: TERMINATED
Conditions: Adults With Uncontrolled Hypertension
Interventions: DEVICE: Symplicity renal denervation system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-prandial Glucose in Healthy Indian Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DIETARY_SUPPLEMENT: plant-based dietary supplement|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A PhaseⅡ Study to Evaluate the Safety & Immunogenicity of SARS-CoV-2 Alpha/Beta/Delta/Omicron Variants COVID-19 Vaccine
Status: COMPLETED
Conditions: COVID-19 Pandemic
Interventions: BIOLOGICAL: SCTV01E|BIOLOGICAL: Placebo (normal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: RejuvenAir™ System Lobectomy Safety and Histology Study
Status: COMPLETED
Conditions: Lung Neoplasms|Airway Obstruction|Lung Cancer
Interventions: DEVICE: RejuvenAir™ Radial Spray Cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Early Detection of Gestational Diabetes Mellitus in Pregnancy
Status: NOT_YET_RECRUITING
Conditions: Gestational Diabetes Mellitus in Pregnancy|Pregnancy, High Risk
Interventions: DIAGNOSTIC_TEST: Enhanced First Trimester GDM Screening|DIAGNOSTIC_TEST: Routine Gestational Diabetes Screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Action of Synbiotics on Irradiated GI Mucosa in Rectal Cancer Treatment
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DIETARY_SUPPLEMENT: Oat bran|DIETARY_SUPPLEMENT: Oat bran and blueberry husks|DIETARY_SUPPLEMENT: No oral supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE)
Status: COMPLETED
Conditions: Malaria,Falciparum
Interventions: DRUG: Proguanil Oral Tablet|DRUG: Sulfadoxine/Pyrimethanine-Amodiaquine (SP-AQ)|DRUG: Dihydroartemisinin-Piperaquine (DP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intrathecal Pemetrexed for SCLC Patients With Refractory Brain Metastases or Leptomeninges Metastatic
Status: NOT_YET_RECRUITING
Conditions: Small-cell Lung Cancer
Interventions: DRUG: Intrathecal Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-emptive Local Anaesthesia in Gynecological Laparoscopy
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Bupivacaine 5mg/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Acute Effects of Incremental Inspiratory Loads on Respiratory Mechanics and NRD in Patient With Stable COPD.
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: PROCEDURE: incremental inspiratory load
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Honghe Fujie Lotion for the Treatment of Bacterial Vaginosis
Status: UNKNOWN
Conditions: Bacterial Vaginitis
Interventions: DRUG: Honghe Fujie lotion|DRUG: Metronidazole Suppositories
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Type of Head Positioning on Retinal Displacement in Vitrectomy for Retinal Detachment
Status: RECRUITING
Conditions: Retinal Detachment|Metamorphopsia
Interventions: BEHAVIORAL: Face down positioning|BEHAVIORAL: Supine positioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Efficacy of Aloevera in the Treatment of Oral Submucous Fibrosis- A Clinical Study
Status: COMPLETED
Conditions: Oral SubMucous Fibrosis
Interventions: DRUG: aloevera juice|DRUG: Hydrocortisone|DRUG: Hyaluronic Acid|DRUG: antioxidant|DRUG: aloevera gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Investigating the Pharmacokinetic Properties of Formulations of NN1218 in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: Faster-acting insulin aspart|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Imiquimod Applied in Dose-Cycle for Actinic Keratoses
Status: COMPLETED
Conditions: Actinic Keratoses
Interventions: DRUG: imiquimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Diagnostic Yield of Cryobiopsy Versus Forceps Biopsy in Endobronchial Lesions:Assiut University Experience
Status: UNKNOWN
Conditions: Endobronchial Lesions
Interventions: DEVICE: cryobiopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Oral PEG vs. Enema in Urgent Colonoscopy for ALGIB
Status: RECRUITING
Conditions: Acute Lower Gastrointestinal Bleeding
Interventions: OTHER: Enema Bowel preparation|OTHER: PEG Bowel preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Gallium Nitrate in Treating Children With Brain Tumor, Neuroblastoma, Rhabdomyosarcoma, Non-Hodgkin's Lymphoma, or Refractory Solid Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Lymphoma|Neuroblastoma|Sarcoma|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: gallium nitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Novel Method to Assess the Cornea Biomechanical Properties With Schiotz Tonometer
Status: UNKNOWN
Conditions: Keratoconus
Interventions: DEVICE: Schiotz tonometer|DEVICE: UVA/riboflavin|DEVICE: femto-LASIK|DEVICE: Tomey SP-100 Pchymeter , Topolyzer Vario|DEVICE: Topcon CT-80, Topcon, Japan|DEVICE: Corvis-ST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Emergence Agitation Between Sevoflurane and Desflurane in Pediatric
Status: COMPLETED
Conditions: Children|Urologic Diseases|Ambulation Difficulty
Interventions: DRUG: Desflurane|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Antithymocyte Globulin in Adults With Myelodysplastic Syndrome
Status: UNKNOWN
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: Antithymocyte globulin (ATG)|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison Between Child-Pugh and Albumin-Bilirubin Scores
Status: COMPLETED
Conditions: Rupture, Spontaneous|Rupture Liver|Hepatocellular Carcinoma|Hepatic Impairment
Interventions: PROCEDURE: Liver resection|OTHER: Transcatheter arterial embolization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Exercise Training on Respiratory Performance in Patients With Fibrosing Interstitial Lung Diseases
Status: COMPLETED
Conditions: Lung Diseases|Interstitial Lung Disease|Fibrosis Lung
Interventions: PROCEDURE: Exercise aerobic training|PROCEDURE: Upper, lower and breathing (ULB) exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Antepartum Study on Use of Interpersonal Psychotherapy at 3 New York City Site
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Interpersonal psychotherapy for depression in pregnancy|BEHAVIORAL: Parenting education program (PEP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency
Status: COMPLETED
Conditions: Adrenal Insufficiency
Interventions: DRUG: hydrocortisone (modified release), oral tablet 20 and 5 mg|DRUG: Hydrocortisone, oral tablet, 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amlodipine/Atorvastatin (Caduet®) Drug Use Investigation (Regulatory Post Marketing Commitment Plan)
Status: COMPLETED
Conditions: Hypertension|Angina Pectoris|Hypercholesterolemia|Familial Hypercholesterolemia
Interventions: DRUG: Amlodipine/Atorvastatin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The INDORSE Study: Inhibition of Dipeptidyl Peptidase IV: Outcomes on Renal Sodium Excretion
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Sitaglitpin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effectiveness of Fluoxetine in Young People for the Treatment of Major Depression and Marijuana Dependence
Status: COMPLETED
Conditions: Depressive Disorder, Major|Cannabis Abuse
Interventions: DRUG: Fluoxetine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GT90001 Plus Nivolumab in Patients With Advanced Hepatocellular Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma|HCC
Interventions: DRUG: Nivolumab|DRUG: GT90001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minds Navigating the Diagnosis of Mild Cognitive Impairment
Status: RECRUITING
Conditions: Cognitive Dysfunction|Mild Cognitive Impairment
Interventions: BEHAVIORAL: Group psychotherapy delivered via video telehealth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of SBRT Followed by Tislelizumab Plus Cetuximab and Irinotecan in Patients With Previously Treated RAS Wild-type Advanced Refractory Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: Tislelizumab|DRUG: Irinotecan Hydrochloride|DRUG: cetuximab|RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proteomics and Orthodontic Root Resorption
Status: COMPLETED
Conditions: Root Resorption|Orthodontic Appliance Complication|Orthodontic Pathological Resorption of External Root|Gingival Diseases|Tooth Plaque|Tooth Diseases
Interventions: PROCEDURE: Heavy Force (225g)|PROCEDURE: Light Force (25g)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Quality of Life in Neoadjuvant Versus Adjuvant Therapy of Esophageal Cancer Treatment Trial
Status: COMPLETED
Conditions: Esophageal Neoplasms
Interventions: OTHER: Preoperative treatment of chemotherapy and radiation|OTHER: Postoperative treatment of chemotherapy and radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Virtual Bodily Illusion Intervention in Upper Limb Motor Function in People With Incomplete Spinal Cord Injury.
Status: RECRUITING
Conditions: Incomplete Spinal Cord Injury|Spinal Cord Injury
Interventions: OTHER: Visual illusion|OTHER: Physical exercise|OTHER: Sham Visual illusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy And Safety Of CX516 In Elderly Participants With Mild Cognitive Impairment.
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: DRUG: CX516|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: the Efficacy and Safety of Spirulina Maxima Extract on Improvement of Cognitive Function
Status: COMPLETED
Conditions: Cognitive Function
Interventions: DIETARY_SUPPLEMENT: Spirulina maxima extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of MEN1112 Intravenous Infusion in Relapsed or Refractory Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Recurrent Adult Acute Myeloid Leukemia|Acute Myeloid Leukemia, in Relapse
Interventions: DRUG: MEN1112
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS
Status: UNKNOWN
Conditions: Anovulatory Infertility Related to Polycystic Ovary Syndrome
Interventions: DRUG: Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Changes in Nasal Airflow of Loratadine/Pseudoephedrine Tablet and Fluticasone Propionate Nasal Spray in Subjects Following Allergen Exposure
Status: COMPLETED
Conditions: Rhinitis, Allergic
Interventions: DRUG: loratadine + pseudoephedrine sulfate (BAY818725/Claritin-D)|DRUG: Placebo tablet|DRUG: Fluticasone Propionate|DRUG: Placebo spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Follow-up of Glutamic Acid Decarboxylase (GAD) Gene Transfer in Parkinson's Disease
Status: ENROLLING_BY_INVITATION
Conditions: Parkinson Disease
Interventions: GENETIC: AAV-GAD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Continued Treatment With Regorafenib in Participants With Solid Tumors Who Have Participated in Other Bayer Studies
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Malignant Tumors
Interventions: DRUG: Regorafenib (Stivarga, BAY73-4506)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Gammacore Sapphire for the Acute and Preventive Treatment of Post-Traumatic Headache (GAP-PTH)
Status: WITHDRAWN
Conditions: Post-Traumatic Headache
Interventions: DEVICE: gammaCore Sapphire|DEVICE: sham gammaCore Sapphire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tislelizumab Combined With Bevacizumab and Albumin Paclitaxel in Lung Adenocarcinoma
Status: COMPLETED
Conditions: Lung Adenocarcinoma Stage IV
Interventions: DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantiferon CMV to Identify Treatment Need For Asymptomatic CMV Infection After Solid Organ Transplant (QUANTIFOT)
Status: NOT_YET_RECRUITING
Conditions: Cytomegalovirus Infections|Heart Transplantation|Kidney Transplantation|Lung Transplantation|Liver Transplantation
Interventions: DIAGNOSTIC_TEST: Quantiferon CMV (assay that determine the presence of CMV-specific T lymphocytes).|OTHER: Communication of the result of the QF-CMV to the clinician in charge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Combination of Water Immersion and Carbon Dioxide Insufflation for Minimal Sedation Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy
Interventions: PROCEDURE: Water immersion insertion AND CO2 insufflation|PROCEDURE: Water immersion insertion|PROCEDURE: CO2 insufflation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Intensity Dependent Effects of 'FAST-Table' on Physical Performance in Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: conventional therapy|OTHER: Task oriented training (moderate intensity)|OTHER: Task oriented training (high intensity)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gene Expression and Tolerability Study of NV1FGF in Patients With Peripheral Artery Occlusive Disease Planned to Undergo Major Amputation
Status: COMPLETED
Conditions: Peripheral Arterial Occlusive Disease
Interventions: DRUG: XRP0038 (NV1FGF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Testing an Omega-3 Fatty Acid-Based Anti-Cancer Therapy for Patients With Triple-Negative Inflammatory Breast Cancer That Has Spread to Other Parts of the Body
Status: TERMINATED
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Triple-Negative Breast Inflammatory Carcinoma
Interventions: DRUG: Dasatinib|DIETARY_SUPPLEMENT: Icosapent Ethyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An App-based Versus a Web-based Self-management Intervention or Usual Care in People With Low Back and/or Neck Pain on a Waiting List for Hospital-based Outpatient Rehabilitation
Status: COMPLETED
Conditions: Back Pain|Neck Pain
Interventions: DEVICE: SelfBACK app|OTHER: e-Help webpage|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reduced Intensity Radio-chemotherapy for Stage IIA/B Seminoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Seminoma|Testicular Cancer
Interventions: DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-operative Pain After Laser Root Canal Treatment of Necrotic Teeth With Apical Periodontitis
Status: COMPLETED
Conditions: Pulp Necroses|Apical Periodontitis|Pulp Disease, Dental
Interventions: DRUG: Conventional group|DEVICE: Dual laser group|COMBINATION_PRODUCT: Combined group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Finding Trial With Sugammadex Administered at 3 and 15 Minutes After 1.0 and 1.2 mg/kg Rocuronium Bromide in Participants of ASA Class 1-3 (P05944; MK-8616-024)
Status: COMPLETED
Conditions: Anesthesia, General
Interventions: DRUG: Sugammadex|DRUG: Placebo|DRUG: Esmeron®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lemborexant Shift Work Treatment Study
Status: RECRUITING
Conditions: Shift-Work Related Sleep Disturbance
Interventions: DRUG: Lemborexant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Examining Techniques on Adenoma Miss Rate in Proximal Colon
Status: UNKNOWN
Conditions: Colorectal Adenoma|Colorectal Polyp
Interventions: PROCEDURE: Retroflexion|PROCEDURE: Re-examination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Letetresgene Autoleucel Engineered T Cells in NY-ESO-1 Positive Participants With Advanced Myxoid/ Round Cell Liposarcoma
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: letetresgene autoleucel (GSK3377794)|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RENEW Scleroderma: A Peer-Mentored, Web Intervention for Resilience-based, Energy Management to Enhance Wellbeing and Fatigue
Status: COMPLETED
Conditions: Scleroderma
Interventions: BEHAVIORAL: RENEW
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TACE-HAIC Plus Atezolizumab and Bevacizumab for Unresectable HCC: a Phase 2 Clinical Trial
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: TACE-HACI, plus atezolizumab-bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Binimetinib and Encorafenib for the Treatment of Pancreatic Cancer in Patients With a Somatic BRAF V600E Mutation
Status: TERMINATED
Conditions: Locally Advanced Pancreatic Carcinoma|Metastatic Pancreatic Carcinoma|Recurrent Pancreatic Carcinoma|Stage III Pancreatic Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8
Interventions: DRUG: Binimetinib|DRUG: Encorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fatty Acid Metabolism in Carriers of Apolipoprotein E Epsilon 4 Allele: Determining the Blood-to-brain Link
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: omega-3 phospholipids|DIETARY_SUPPLEMENT: omega-3 Triglycerides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Secondary Prevention of Osteoporosis
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: alendronate with cholecalciferol|DRUG: calcium carbonate with cholecalciferol|BEHAVIORAL: Falls prevention measures
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine + Oxaliplatin +Nab-paclitaxel in Subjects With Advanced Biliary Tract Cancer
Status: UNKNOWN
Conditions: Cholangiocarcinoma
Interventions: DRUG: nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of PXL065 in Patients With Nonalcoholic Steatohepatitis (NASH)
Status: COMPLETED
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: DRUG: PXL065|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Safety and Effectiveness of TQB2618 Injection Combined Therapy in Patients With Advanced Esophageal Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Advanced Esophageal Squamous Cell Carcinoma
Interventions: DRUG: TQB2618 injection, Penpulimab injection, Paclitaxel, Cisplatin|DRUG: Penpulimab injection, Paclitaxel, Cisplatin|DRUG: TQB2618 injection, Penpulimab injection, TQB3617capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of JDQ443 Single-agent as First-line Treatment for Patients With Locally Advanced or Metastatic KRAS G12C- Mutated Non-small Cell Lung Cancer With a PD-L1 Expression < 1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation.
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced or Metastatic KRAS G12C-mutated NSCLC With a PD-L1 Expression <1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation
Interventions: DRUG: JDQ443
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Restoration of Vision After Stroke
Status: UNKNOWN
Conditions: Stroke|Infarction; Posterior Cerebral Artery|Hemianopsia
Interventions: DEVICE: Active tACS using DC-Stimulator MC|DEVICE: Sham stimulation using DC-Stimulator MC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nerve Blocks in Alloplastic Breast Reconstruction
Status: RECRUITING
Conditions: Surgery, Plastic|Mastectomy|Nerve Block|Breast Reconstruction
Interventions: DRUG: Thoracic paravertebral block|DRUG: Pecs block|DRUG: Sham Pecs block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Study of Postoperative Adjuvant Chemotherapy of Uracil- Tegafur (UFT) Compared With Surgery Alone (NSAS-GC)
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: UFT (uracil, tegafur)|PROCEDURE: Surgery alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Prazosin on Neurophysiology and Cognition in Post-Traumatic Stress Disorder (PTSD)
Status: WITHDRAWN
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: prazosin hydrochloride|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial of Beads Versus Doxorubicin Eluting Beads for Arterial Embolization of Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Liver Cancer|Hepatoma
Interventions: DEVICE: Bead Block microspheres|OTHER: Bead + Dox Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Myo-inositol Plus Alpha-lactalbumin in PCOS Myo-inositol-resistant Patients
Status: WITHDRAWN
Conditions: PCOS|Myo-inositol-resistance
Interventions: DIETARY_SUPPLEMENT: Myo-inositol + folic a. + α-lactalbumin|DIETARY_SUPPLEMENT: Myo-inositol + folic a.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Modafinil for Treatment of Cognitive Dysfunction in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: modafinil|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Clinical Performance of Apneal®, a Medical Device on Smartphone, for Sleep Apnea-hypopnea Syndrome Diagnosis.
Status: RECRUITING
Conditions: Sleep Apnea Syndromes
Interventions: DEVICE: Apneal device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Lung and Inferior Vena Cava Sonography for Fluid Optimization
Status: UNKNOWN
Conditions: Traumatic Brain Injury
Interventions: PROCEDURE: Standard care (control group)|PROCEDURE: US-guided ﬂuid management (active group)|OTHER: Standard ICU Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Long-acting Injectable Cabotegravir for HIV PrEP in MSM in France.
Status: NOT_YET_RECRUITING
Conditions: Prevention
Interventions: DRUG: Cabotegravir Tablets, for oral use.|DRUG: Cabotegravir Extended-Release Injectable Suspension, for intramuscular use.|DRUG: Tenofovir disoproxil/Emtricitabine 300mg/200mg fixed-dose combination tablets, for oral use|PROCEDURE: Rectal Biopsies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Drug Interaction Between Daclatasvir/Asunaprevir/BMS-791325 and Rosuvastatin
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Daclatasvir, Asunaprevir and BMS-791325 FDC|DRUG: BMS-791325|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Feasibility of a High-intensity Interval Training Program in Persons With Multiple Sclerosis Who Have Walking Disability
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Recumbent Stepping, High-Intensity Interval Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Quadripolar Leads for the Management of Heart Failure Patients in the Middle East
Status: UNKNOWN
Conditions: Heart Failure
Interventions: OTHER: Electrical optimization by RVLV Conduction Time with VectSelect|OTHER: Anatomical optimization of device and leads|DEVICE: Implanted device and lead (Cardiac Resynchronization Therapy Defibrillator (CRT-D) device and SJM Quadripolar lead system)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Neurostatus-SMARTCARE in Comparison to Standard Neurostatus-EDSS®
Status: COMPLETED
Conditions: Multiple Sclerosis (MS)
Interventions: OTHER: Neurostatus-SMARTCARE|OTHER: Standard Neurostatus-EDSS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Photosensitization Study in Androgenetic Alopecia
Status: COMPLETED
Conditions: Androgenetic Alopecia
Interventions: DRUG: Finasteride 0.25%|DRUG: Placebo for Finasteride 0.25%|DRUG: Negative Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Controlled Study of Rigosertib Versus Physician's Choice of Treatment in MDS Patients After Failure of an HMA
Status: TERMINATED
Conditions: Myelodysplastic Syndrome|MDS|Refractory Anemia With Excess Blasts|RAEB
Interventions: DRUG: rigosertib|DRUG: Any approved or standard-of-care therapy|DRUG: best supportive care (BSC)|DRUG: best supportive care (BSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ponatinib Followed by Imatinib in Patients With Chronic Myelogenous Leukemia in Chronic Phase
Status: ACTIVE_NOT_RECRUITING
Conditions: Philadelphia Chromosome Positive CML|BCR-ABL Positive Chronic Myelogenous Leukemia
Interventions: DRUG: Ponatinib|DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Safety and Efficacy of AEGR-733 and Atorvastatin vs Atorvastatin Monotherapy in Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Atorvastatin|DRUG: AEGR-733
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Telephone-based Case-management Intervention for Caries Prevention in Children With Severe Early Childhood Caries
Status: COMPLETED
Conditions: Early Childhood Caries
Interventions: BEHAVIORAL: A telephone-based case-management intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of B-cell Depletion in Patients With Primary Sjögren's Syndrome
Status: COMPLETED
Conditions: Primary Sjögren's Syndrome|Xerostomia|Hyposalivation|Keratoconjunctivitis Sicca|Fatigue
Interventions: DRUG: MabThera (rituximab)|DRUG: Rituximab, Mabthera
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Retrospective, Observational, Multicentre, Study to Evaluate the Safety and Performance of POLYPATCH ® Vascular Patch
Status: COMPLETED
Conditions: Artery Stenosis, Carotid|Artery Stenosis|Occlusion of Artery|Stroke
Interventions: DEVICE: Endarterectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Transmural Plastic Stent on Recurrence of Pancreatic Fluid Collection After Metal Stent Removal in Disconnected Pancreatic Duct
Status: COMPLETED
Conditions: Acute Pancreatitis Necrotizing
Interventions: DEVICE: Transmural Plastic stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT