pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Evaluate the Efficacy and Safety of AK102 Q6W in Patients With Hyperlipidemia
Status: UNKNOWN
Conditions: Hyperlipidemia
Interventions: BIOLOGICAL: AK102|BIOLOGICAL: AK102|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cediranib Maleate and Combination Chemotherapy in Treating Patients With Advanced Biliary Cancers
Status: TERMINATED
Conditions: Adult Primary Cholangiocellular Carcinoma|Advanced Adult Primary Liver Cancer|Cholangiocarcinoma of the Extrahepatic Bile Duct|Cholangiocarcinoma of the Gallbladder|Localized Unresectable Adult Primary Liver Cancer|Periampullary Adenocarcinoma|Recurrent Adult Primary Liver Cancer|Recurrent Extrahepatic Bile Duct Cancer|Recurrent Gallbladder Cancer|Unresectable Extrahepatic Bile Duct Cancer|Unresectable Gallbladder Cancer
Interventions: DRUG: cediranib maleate|DRUG: oxaliplatin|DRUG: leucovorin calcium|DRUG: fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-op Rectal ChemoRad +/- Cetuximab
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DRUG: Cetuximab|DRUG: 5-fluorouracil|RADIATION: Pelvic irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azacitidine Combined With Venetoclax in Patients With Higher-risk Chronic Myelomonocytic Leukemia (AVENHIR)
Status: RECRUITING
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expanded Natural Killer Cell Infusion in Treating Younger Patients With Recurrent/Refractory Brain Tumors
Status: COMPLETED
Conditions: Recurrent Childhood Medulloblastoma|Recurrent Ependymoma|Recurrent Medulloblastoma
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Natural Killer Cell Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RAM Cannula VS Short Nasal Prongs for Delivering NIPPV in Preterm Infants
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Newborn|Noninvasive Ventilation|Infant, Premature|Intubation, Intratracheal
Interventions: DEVICE: Ram cannula|DEVICE: Short nasal prongs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: M7824 in Subjects With HPV Associated Malignancies
Status: COMPLETED
Conditions: Human Papilloma Virus|Cervical Cancer|Oropharyngeal Cancer|Anal Cancer|Vaginal or Penile Cancer
Interventions: DRUG: M7824
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Sugammadex vs. Neostigmine Reversal on Post-Operative Recovery and Complications
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: Sugammadex Sodium|DRUG: Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MitoQ for the Treatment of Metabolic Dysfunction in Asthma
Status: COMPLETED
Conditions: Asthma|Obesity
Interventions: DRUG: Mitoquinol|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Window of Opportunity Trial to Learn if Linvoseltamab is Safe and Well Tolerated, and How Well it Works in Adult Participants With Recently Diagnosed Multiple Myeloma Who Have Not Already Received Treatment
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Linvoseltamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Bioequivalence of Two Batches of Tamsulosin Hydrochloride in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Flomax®, Norman II facility|DRUG: Flomax®, Nishine facility
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients with Medical Xerostomia
Status: NOT_YET_RECRUITING
Conditions: Xerostomia|Graft-versus-host-disease|Sjogren's Disease
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "ALOFT - Aliskiren Observation of Heart Failure Treatment": Efficacy and Safety of Aliskiren Added on Top of Standard Therapy in Adults (≥ 18 Years) With Stable Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: aliskiren
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: OTHER
Clinical trial: Study to Examine the Effects of ATP Supplementation on Muscle Excitability and Reaction Time During and Following a Repeated Sprint Bout
Status: COMPLETED
Conditions: Muscle Fatigue Caused by Repetitive Muscle Exercise
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: ATP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tesamorelin to Improve Functional Outcomes After Peripheral Nerve Injury
Status: RECRUITING
Conditions: Peripheral Nerve Injuries
Interventions: DRUG: Tesamorelin 2 Milligrams (MG)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CBM588, Nivolumab, and Ipilimumab in Treating Patients With Stage IV or Advanced Kidney Cancer
Status: COMPLETED
Conditions: Advanced Renal Cell Carcinoma|Clear Cell Renal Cell Carcinoma|Metastatic Renal Cell Carcinoma|Stage III Renal Cell Cancer AJCC v8|Stage IV Renal Cell Cancer AJCC v8|Unresectable Renal Cell Carcinoma
Interventions: DRUG: Clostridium butyricum CBM 588 Probiotic Strain|BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Clinical Endpoints of Two Diclofenac Sodium Gel 1%
Status: COMPLETED
Conditions: Osteo Arthritis of the Knee
Interventions: DRUG: Diclofenac|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of JNJ-53718678 in Adult and Adolescent Participants Who Had a Hematopoietic Stem Cell Transplantation and Who Are Infected With Respiratory Syncytial Virus (RSV)
Status: TERMINATED
Conditions: Respiratory Syncytial Virus Infections
Interventions: DRUG: JNJ-53718678 250 mg|DRUG: Placebo|DRUG: JNJ-53718678 125 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnosis of Carpal Tunnel Syndrome: Effectiveness of Diagnostic Tests. Clinical Trial of Accuracy
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome|Compression Neuropathy, Carpal Tunnel|Median Neuropathy, Carpal Tunnel
Interventions: DIAGNOSTIC_TEST: accuracy diagnostic
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Determine the Improvement in Activity Status/Quality of Life (QoL) of Patients With Rheumatoid Arthritis (RA) During Treatment With Lodotra (Prednisone)
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Prednisone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vitamin D to Improve Quadricep Muscle Strength
Status: RECRUITING
Conditions: Anterior Cruciate Ligament Injuries|Quadriceps Muscle Atrophy|Anterior Cruciate Ligament Rupture|Anterior Cruciate Ligament Tear
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: CETUXIMAB Given for 3 Weeks as Neoadjuvant Treatment in Locally Advanced Tongue Cancer ; A NEW PARADIGM OF TREATMENT
Status: UNKNOWN
Conditions: Squamous Cell Carcinoma
Interventions: DRUG: Erbitux,merck serono
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Amethocaine Gel for Intramuscular Injection in Term Neonates
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Eucerin plus|DRUG: Amethocaine gel 4%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anthocyanin Dose-escalation Study in Healthy Young Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Anthocyanin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A sTudy of Low Dose vs Standard Dose of tIcaGrelor on Platelet Function After intErvention for Acute Coronary syndRome in Diabetes Mellitus Patients
Status: RECRUITING
Conditions: Acute Coronary Syndrome Patients With Diabetes After PCI
Interventions: DRUG: Ticagrelor|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alternate Dosing Regimens of BG00012 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Dimethyl Fumarate (BG00012)|DRUG: Aspirin|DRUG: BG00012 matching placebo|DRUG: ASA matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase III Multinational Multicenter Investigator-Masked Randomized Active-Controlled Trial Comparing the Efficacy and Safety of DE-130A With Xalatan® in Patients With Open-Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-Angle Glaucoma or Ocular Hypertension|Ocular Surface Disease
Interventions: DRUG: DE-130A|DRUG: Xalatan®|DRUG: DE-130A/DE-130A|DRUG: Xalatan®/DE-130A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: McNeill Dysphagia Therapy Program Combined With Transcranial Magnetic Stimulation
Status: NOT_YET_RECRUITING
Conditions: Dysphagia
Interventions: DEVICE: Transcranial Magnetic Stimulation+McNeill Dysphagia Therapy Programme|DEVICE: Sham Transcranial Magnetic Stimulation +McNeill Dysphagia Therapy Programme|DEVICE: Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Efficacy and Safety of the Ketoprofen vs Diclofenac
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Ketoprofen topical|DRUG: Diclofenac Topical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients Who Are Undergoing Surgery for Ductal Carcinoma In Situ of the Breast
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: therapeutic autologous dendritic cells|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Clazosentan in Reducing Vasospasm-related Morbidity and All-cause Mortality in Adult Patients With Aneurysmal Subarachnoid Hemorrhage Treated by Surgical Clipping
Status: COMPLETED
Conditions: Aneurysmal Subarachnoid Hemorrhage
Interventions: DRUG: Clazosentan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Resuscitative Balloon Occlusion of the Aorta in Non-traumatic Out of Hospital Cardiac Arrest
Status: COMPLETED
Conditions: Out-of-Hospital Cardiac Arrest
Interventions: PROCEDURE: Resuscitative Balloon Occlusion of the Aorta|DEVICE: REBOA catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Low Level Laser Therapy on İnjection Pain
Status: WITHDRAWN
Conditions: Pediatric Anesthesia|Low Level Laser Theraphy
Interventions: DEVICE: Diode Laser|OTHER: topical anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of LUMA Cervical Imaging System as Adjunct to Colposcopy
Status: TERMINATED
Conditions: Dysplasia|Cancer
Interventions: DEVICE: Luma Cervical Imaging System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Tolerability and Pharmacokinetics of PUR1900 (Itraconazole Powder) in Healthy Volunteers and Adults With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Itraconazole Powder|DRUG: Itraconazole 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunoadsorption in Patients With Pulmonary Hypertension
Status: WITHDRAWN
Conditions: Pulmonary Hypertension|Pulmonary Resistance
Interventions: PROCEDURE: immunoadsorption / immunglobulin substitution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cells to Intervene in the Development of Type 1 Diabetes: a Blinded Randomized Study
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus
Interventions: BIOLOGICAL: autologous mesenchymal stem cell transplantation|PROCEDURE: sham transplantation of mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Medication Change for Non-Responders
Status: TERMINATED
Conditions: Binge-Eating Disorder|Obesity
Interventions: DRUG: Naltrexone and Bupropion|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrating Conservative Kidney Management Options and Advance Care Planning Into a Pre-Dialysis Educational Program
Status: TERMINATED
Conditions: Advance Care Planning|Chronic Kidney Diseases|Conservative Kidney Management
Interventions: OTHER: ESRD education + conservative kidney management and ACP education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Alternative Therapies for Menopause: A Randomized Trial
Status: COMPLETED
Conditions: Menopause|Hot Flashes
Interventions: DRUG: Hormone Replacement Therapy|DRUG: Cimicifuga racemosa (Black Cohosh)|DRUG: Multibotanical phytoestrogen formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Uncomplicated Nausea and Vomiting in the Emergency Department
Status: COMPLETED
Conditions: Nausea|Vomiting
Interventions: DRUG: Ondansetron|DRUG: Ondansetron|DRUG: Metoclopramide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Expanding Rural Access: Distance Delivery of Support
Status: COMPLETED
Conditions: Breast Cancer|Stress Disorders, Post-Traumatic|Depression
Interventions: BEHAVIORAL: workbook/journal on coping with breast cancer|BEHAVIORAL: supportive expressive group therapy using videoconferencing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aflibercept for Macular Oedema With Underlying Retinitis Pigmentosa (AMOUR) Study
Status: COMPLETED
Conditions: Macular Oedema|Retinitis Pigmentosa
Interventions: DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lactobacillus Reuteri DSM 17938 and Prevention of Respiratory and Gastrointestinal Infections in Mexican Infants
Status: UNKNOWN
Conditions: Healthy Infants
Interventions: DIETARY_SUPPLEMENT: Lreuteri|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Aerobic Dance Based Exercise Program After Surgery in Obeses Awating Bariatric Surgery
Status: COMPLETED
Conditions: Morbid Obesity|Bariatric Surgery Candidate|Exercise|Obesity
Interventions: OTHER: Exercise treatment|OTHER: Counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Repeat Dosing of GSK233705/GW642444 in COPD
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Placebo|DRUG: GSK233705/GW642444
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics Study of CPL207280 Compound in Healthy Volunteers.
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: CPL207280|DRUG: Placebo|DRUG: Metformin hydrochloride 750 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Clinical Application of 68Ga-NOTA-exendin-4 PET/CT in Detecting Insulinoma
Status: RECRUITING
Conditions: Insulinoma
Interventions: DRUG: 68Ga-NOTA-exendin-4
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study To Evaluate The Safety And Efficacy Of PF-04958242 In Subjects With Cognitive Impairment Associated With Schizophrenia (CIAS)
Status: TERMINATED
Conditions: Cognitive Impairment Associated With Schizophrenia (CIAS)
Interventions: DRUG: PF-04958242|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia
Status: UNKNOWN
Conditions: Pleural Effusion, Malignant|Pleural Mesothelioma|Pleural Empyema|Pulmonary Diseases or Conditions|Pleural Neoplasms|Pulmonary Atelectasis|Pleural Diseases|Pericardial Effusion|Mediastinal Lymphadenopathy|Pneumothorax and Air Leak|Hemothorax|Pyopneumothorax
Interventions: PROCEDURE: Thoracic Epidural Anesthesia|PROCEDURE: General Anesthesia with One Lung Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SCS Stimulation Clamp to Assess Impact of Stimulation on Glucose Metabolism
Status: COMPLETED
Conditions: Spinal Cord Stimulation (SCS)|Blood Glucose Metabolism|Euglycemic Hyperinsulinemic Clamp
Interventions: DEVICE: Sham SCS stimulation|DEVICE: Tonic SCS stimulation|DEVICE: Burst SCS Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vitamin C, Thiamine and Hydrocortisone for the Treatment of Septic Shock
Status: COMPLETED
Conditions: Septic Shock
Interventions: DRUG: Vitamin C,thiamine,hydrocortisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Relative Efficacy and Safety Study of OC Oral Solution for Sialorrhoea in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Sialorrhoea
Interventions: DRUG: oxybutynin and clonidine oral solution treatment A|DRUG: oxybutynin and clonidine oral solution treatment B|DRUG: oxybutynin and clonidine oral solution treatment C|DRUG: oxybutynin and clonidine oral solution treatment D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Modified Diet Trial: A Study of SMT C1100 in Paediatric Patients With DMD Who Follow a Balanced Diet
Status: COMPLETED
Conditions: Muscular Dystrophy, Duchenne
Interventions: DRUG: SMT C1100|DRUG: SMT C1100|DRUG: SMT C1100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-induction Analgesia: Multimodel Regimen vs Aceteminophen for Post Ureteroscopy Pain
Status: WITHDRAWN
Conditions: Kidney Calculi|Pain, Postoperative
Interventions: DRUG: Multimodal Oral Drug Regimen|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Stellate Ganglion Block on ME/CFS
Status: ACTIVE_NOT_RECRUITING
Conditions: Encephalomyelitis, Myalgic|Chronic Fatigue Syndrome|Chronic Fatigue Disorder|Chronic Fatigue and Immune Dysfunction Syndrome|Myalgic Encephalomyelitis|Postviral Fatigue Syndrome|Systemic Exertion Intolerance Disease|Infectious Mononucleosis-Like Syndrome, Chronic|Chronic Fatigue-Fibromyalgia Syndrome
Interventions: DRUG: Bupivacaine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise and Dry Needling Treatment Combination in Nocturnal Calf Cramps
Status: UNKNOWN
Conditions: Nocturnal Leg Cramps|Myofascial Pain Syndrome
Interventions: OTHER: Stretching exercise|OTHER: Dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zoledronic Acid - Letrozole Adjuvant Synergy Trial (ZFAST) - Cancer Treatment Related Bone Loss in Postmenopausal Women With Estrogen Receptor Positive and/or Progesterone Receptor Positive Breast Cancer Receiving Adjuvant Hormonal Therapy
Status: COMPLETED
Conditions: Breast Neoplasms|Osteoporosis
Interventions: DRUG: Zoledronic Acid|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Dose Ranging Pilot Study for Intracerebroventricular (ICV) Delivery of Valproate in Subjects With Temporal Seizures
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Valproate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes of Local Treatment for Oligometastatic Prostate Cancer Diagnosed Using PSMA PET Imaging: OLIGOMET Study
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer Metastatic|Prostate Cancer Metastatic to Bone|Prostate Cancer|Prostate Neoplasm|Oligometastatic Disease|Oligometastasis
Interventions: PROCEDURE: Radical prostatectomy|RADIATION: Prostate irradiation|PROCEDURE: Surgical metastasectomy|RADIATION: Irradiation of metastases|DRUG: Abiraterone acetate|DRUG: Enzalutamide|DRUG: Darolutamide|DRUG: Apalutamide|DRUG: Docetaxel|DRUG: Lutetium-PSMA|DRUG: Androgen deprivation treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomised Controlled Trial of Coenzyme Q10 in Patients With Schizophrenia and Schizoaffective Disorder
Status: UNKNOWN
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DIETARY_SUPPLEMENT: Coenzyme Q10|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Closure of Atrial Septal Defects in Children: Integration of 3D Echocardiography and Fluoroscopy Imaging.
Status: COMPLETED
Conditions: Atrial Septal Defects
Interventions: DEVICE: "Echonavigator" software
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Prefrontal Cortex Dynamics of the Elderly During a Cognitive Stimulation Programme
Status: COMPLETED
Conditions: Dementia|Neurocognitive Disorders|Cognitive Impairment|Cognitive Dysfunction|Cognitive Decline|Cognition Disorders in Old Age
Interventions: BEHAVIORAL: Individual cognitive stimulation therapy (iCST)|PROCEDURE: Functional near-infrared spectroscopy (fNIRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Home Use of Automatic External Defibrillators to Treat Sudden Cardiac Arrest
Status: COMPLETED
Conditions: Cardiovascular Diseases|Myocardial Infarction|Heart Diseases|Death, Sudden, Cardiac
Interventions: OTHER: Cardiopulmonary Resuscitation|DEVICE: Automatic External Defibrillation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetic Interaction Between Maraviroc And Fosamprenavir/Ritonavir In Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Maraviroc|DRUG: Fosamprenavir/ritonavir|DRUG: Maraviroc + Fosamprenavir/ritonavir|DRUG: Maraviroc|DRUG: Fosamprenavir/ritonavir|DRUG: Maraviroc + Fosamprenavir/ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The European Collaborative Project on Inflammation and Vascular Wall Remodeling in Atherosclerosis - Intravascular Ultrasound Study
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: OTHER: Drawing blood samples|DEVICE: Coronary intravascular ultrasound imaging|DEVICE: Coronary near-infrared spectroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate the Safety and Efficacy of Secukinumab 300 mg and 150 mg in Adult Patients With Active Psoriatic Arthritis (PsA) After 16 Weeks of Treatment Compared to Placebo
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Secukinumab 300 mg|DRUG: Secukinumab 150 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Trial Evaluating mFOLFOX6 and Avastin With Nexavar as First-Line Treatment for Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: sorafenib|DRUG: bevacizumab|DRUG: mFOLFOX6 regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiopulmonary Changes Following Spinal Cord Stimulation in Individuals With Spinal Cord Injury
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injuries|Cardiovascular Diseases|Cardiopulmonary Diseases
Interventions: DEVICE: Transcutaneous Spinal Cord Stimulation (tSCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunohistochemical Staining of p16 for the Screening of Cervical Cancer
Status: UNKNOWN
Conditions: Cervical Cancer Screening|p16 Protein|Cytology|High-risk Human Papillomavirus|Diagnostic Accuracy|Histology|Cervical Intraepithelial Neoplasia
Interventions: DIAGNOSTIC_TEST: p16 protein expression
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Fasting on Self Efficacy
Status: COMPLETED
Conditions: Chronic Pain|Fibromyalgia|Rheumatoid Arthritis|Gout|Headache|Arthritis|Gastrointestinal Diseases|Irritable Bowel Syndrome|Inflammatory Bowel Disease|Cardiovascular Diseases
Interventions: BEHAVIORAL: Fasting
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Explore Pharmacokinetics/Pharmacodynamics and Safety of Tegoprazan BID Dosing in Healthy Subjects
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: Tegoprazan dose A or placebo|DRUG: Tegoprazan dose B or placebo|DRUG: Tegoprazan dose C or placebo|DRUG: Tegoprazan dose D or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Beta-blockers in Pulmonary Arterial Hypertension
Status: TERMINATED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Carvedilol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of MDV3100 in Patients With Castration-Resistant Prostate Cancer Who Have Been Previously Treated With Docetaxel-based Chemotherapy
Status: COMPLETED
Conditions: Castration-Resistant Prostate Cancer
Interventions: DRUG: Enzalutamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Collaborative Care for Alcohol Use Disorders in the Patient-centered Medical Home
Status: COMPLETED
Conditions: Alcohol-Related Disorders|Alcohol Drinking|Alcoholism|Alcohol Abuse|Alcohol Use Disorders
Interventions: BEHAVIORAL: Motivation Enhancement Therapy|BEHAVIORAL: Modified Behavioral Self-Control Therapy|DRUG: Naltrexone|BEHAVIORAL: Brief Advice|OTHER: Referral to specialty substance use disorder treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficiency of Icotinib in Plasma ctDNA EGFR Mutation-positive Patients Diagnosed With Lung Cancer
Status: UNKNOWN
Conditions: Plasma EGFR Mutation-positive Lung Cancer
Interventions: DRUG: Icotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Navigated Laser In Branch Retinal Vein Occlusion Study
Status: COMPLETED
Conditions: Branch Retinal Vein Occlusion|Macular Edema
Interventions: DRUG: Aflibercept Injection [Eylea]|PROCEDURE: Navigated laser photocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Gralise® for Chronic Pelvic Pain
Status: TERMINATED
Conditions: Irritable Bowel Syndrome|Ulcerative Colitis|Interstitial Cystitis|Prostatitis|Pelvic Pain
Interventions: DRUG: Gralise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ublituximab + TGR-1202 Compared to Obinutuzumab + Chlorambucil in Participants With Untreated and Previously Treated Chronic Lymphocytic Leukemia
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: Obinutuzumab|BIOLOGICAL: Ublituximab|DRUG: TGR-1202|DRUG: Chlorambucil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sotalol in Children With Arrhythmia
Status: UNKNOWN
Conditions: Arrhythmia
Interventions: DRUG: sotalol|DRUG: Propafenone|DRUG: betaloc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GL701 (Prestara™) in Women With Systemic Lupus Erythematosus Receiving Treatment With Glucocorticoids
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Prasterone (GL701)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Quinine Hydrochloride in Overweight Population on Food Intake, Hunger and Gut Peptide Release
Status: RECRUITING
Conditions: Obesity
Interventions: DRUG: Quinine Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Sorafenib Tosylate in Treating Patients With Progressive Metastatic Neuroendocrine Tumors
Status: COMPLETED
Conditions: Gastrinoma|Glucagonoma|Insulinoma|Metastatic Gastrointestinal Carcinoid Tumor|Neuroendocrine Tumor|Pancreatic Polypeptide Tumor|Recurrent Gastrointestinal Carcinoid Tumor|Recurrent Islet Cell Carcinoma|Somatostatinoma|WDHA Syndrome
Interventions: DRUG: sorafenib tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare D961H 20 mg Bid and 20 mg qd in Patients With Refractory Reflux Esophagitis (Inflammation of Lower Esophagus)
Status: COMPLETED
Conditions: Refractory Reflux Esophagitis
Interventions: DRUG: Esomeprazole (D961H) twice daily|DRUG: Esomeprazole (D961H) once daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neglect Treatment by Prism Adaptation in the Acute Phase
Status: RECRUITING
Conditions: Unilateral Spatial Neglect
Interventions: BEHAVIORAL: Prism 10 + visuo-motor activities|BEHAVIORAL: Neutral Prism + visuo-motor activities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: An Dose Escalation Trial of Oral BIBF 1120 in Combination With Intravenous Vinorelbine in Elderly Patients With Advanced Non Small Lung Cell Cancer - Stage IV (VENUS-1)
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: BIBF 1120|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ceramic-on-Ceramic (COC) 36mm Acetabular Bearing Insert Post Approval Study-New Subjects (COC36mmPAS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-inflammatory Degenerative Joint Disease|Osteoarthritis|Avascular Necrosis|Post-Traumatic Osteoarthritis of Hip
Interventions: DEVICE: COC 36mm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Ablative Radiotherapy (SAbR) for Treatment of Ventricular Tachycardia (VT) Refractory Standard Invasive Ablation Techniques
Status: WITHDRAWN
Conditions: Tachycardia, Ventricular
Interventions: RADIATION: Stereotactic ablative radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of High-Intensity Interval Training Compared to Hydrochlorothiazide on Ambulatory Blood Pressure
Status: UNKNOWN
Conditions: Hypertension,Essential|Exercise Activity
Interventions: OTHER: 24h-Ambulatory Blood Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Dato-Dxd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
Status: RECRUITING
Conditions: Endometrial Cancer|Gastric Cancer|Metastatic Castration-resistant Prostate Cancer|Ovarian Cancer|Colorectal Cancer|Urothelial Cancer|Biliary Tract Cancer
Interventions: DRUG: Datopotamab deruxtecan (Dato-DXd)|DRUG: Capecitabine|DRUG: 5-Fluorouracil|DRUG: Volrustomig|DRUG: Carboplatin|DRUG: Leucovorin LV|DRUG: Bevacizumab|DRUG: Rilvegostomig|DRUG: Prednisone/ prednisolone|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Phenotype and Capillary Refill Time-targeted Resuscitation Strategy
Status: RECRUITING
Conditions: Septic Shock
Interventions: OTHER: CRT-targeted strategy associated with a clinical hemodynamic phenotyping to personalize initial resuscitation in septic shock patients|OTHER: Usual care (UC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Peripheral Capillary Oxygen Saturation (SpO2): Vital Signs Patch (VSP)
Status: COMPLETED
Conditions: Desaturation of Blood
Interventions: DEVICE: Vital Signs Patch (VSP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Topotecan in Treating Patients With Recurrent, Progressive, or Refractory Cancer That is Metastatic to the Lining Around the Brain
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Δ9-THC (Namisol®) in Chronic Pancreatitis Patients Suffering From Persistent Abdominal Pain
Status: COMPLETED
Conditions: Pancreatitis, Chronic|Abdominal Pain|Chronic Pain
Interventions: DRUG: Tetrahydrocannabinol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Web-Based Collaborative Care for Patients With Diabetes and Depression
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Depression
Interventions: DEVICE: web-based collaborative care|OTHER: wait-list|BEHAVIORAL: usual diabetes outpatient care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chemoradiotherapy With Elective Low Dose Nodal Radiation for Locally Advanced Head and Neck Cancer
Status: UNKNOWN
Conditions: Head and Neck Cancer
Interventions: DRUG: Cisplatin|RADIATION: Elective Nodal Irradiation (ENI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 52-week Post-marketing, Observational Study to Confirm the Safety and Efficacy of Zetia Alone or in Combination With Other Lipid-lowering Drugs in Japanese Subjects With Hypercholesterolemia (Study P05245)
Status: COMPLETED
Conditions: Hypercholesterolemia|Familial Hypercholesterolemia|Homozygous Sitosterolemia
Interventions: DRUG: Ezetimibe|DRUG: Ezetimibe + other lipid-lowering medication(s)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of DTaP-IPV-Hep B-PRP~T Combined Vaccine Compared With PENTAXIM™ and ENGERIX B® PEDIATRICO in Argentinean Infants
Status: COMPLETED
Conditions: Diphtheria|Tetanus|Pertussis|Haemophilus Influenzae Type b|Poliomyelitis
Interventions: BIOLOGICAL: DTaP-IPV-HB-PRP~T|BIOLOGICAL: DTaP-IPV//PRP~T combined vaccine & Recombinant hep B vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Alcohol And Sexual Risk Behavior
Status: RECRUITING
Conditions: Sexually Aggressive Behavior|Risky Sexual Behavior|Heavy Episodic Drinking
Interventions: BEHAVIORAL: Personalized Feedback|BEHAVIORAL: Cognitive Skills Training|OTHER: Services As Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Research Study to Learn About the Effect and Safety of Different Doses of FE 999302 When Given as a Single Dose for Final Development of the Eggs After Ovarian Stimulation
Status: WITHDRAWN
Conditions: Infertility
Interventions: DRUG: FE 999302|DRUG: Ovitrelle|DRUG: Novarel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of Non-invasive Methods to Study Gut Microbiome - Nutrition - Host Interactions
Status: RECRUITING
Conditions: Healthy
Interventions: OTHER: Screening visit|OTHER: Lactulose test|OTHER: Administration of standardized meals with characterized dietary fiber content
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: KPT-330 Plus RICE for Relapsed/Refractory Aggressive B-Cell Lymphoma
Status: COMPLETED
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: KPT-330|DRUG: Rituximab|DRUG: Etoposide|DRUG: Carboplatin|DRUG: Ifosfamide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy Study of the Xoft® Axxent® eBx® IORT System® "Lite"
Status: WITHDRAWN
Conditions: Invasive Ductal Carcinoma|Ductal Carcinoma In Situ
Interventions: RADIATION: Intra-operative Radiation Therapy - IORT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Oropharyngeal Strengthening on Dysphagia in Patients Post-stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Isometric Progressive Resistance Oropharyngeal Therapy|BEHAVIORAL: Compensatory approaches
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab Combined With PLD For Recurrent Platinum Resistant Ovarian, Fallopian Tube Or Peritoneal Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Pegylated Liposomal Doxorubicin (PLD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Three-part Study to Determine the Safety, Tolerability and Pharmacokinetics of GSK1322322 in Healthy Volunteers and Healthy Male Japanese Subjects
Status: TERMINATED
Conditions: Infections, Bacterial
Interventions: DRUG: GSK1322322 Initial fit for purpose tablets|DRUG: GSK1322322 over granulated tablets|DRUG: GSK1322322 intended commercial tablets|DRUG: Placebo tablets|DRUG: 13C-GSK1322322 stable isotope powder|DRUG: GSK1322322 for injection|DRUG: Placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: S9900: Surgery With or Without Combination Chemotherapy in Treating Patients With Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: paclitaxel|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Association of Peri-implantitis and Maxillary Sinusitis: a Case-control Study".
Status: RECRUITING
Conditions: Peri-Implantitis|Sinusitis|Sinusitis, Acute|Sinusitis, Chronic|Implant Infection|Dental Implant Failure Nos
Interventions: OTHER: Retrospective analysis of demographic and radiographic data previously obtained from the patient.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MDR - Comprehensive Primary/Micro Stem & Versa-Dial Ti Humeral Head
Status: ENROLLING_BY_INVITATION
Conditions: Shoulder Pain|Shoulder Injuries|Shoulder Fractures|Shoulder Disease|Shoulder Arthritis
Interventions: DEVICE: Comprehensive Primary Micro Stem|DEVICE: Comprehensive Anatomic Versa-Dial Titanium Humeral Head
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Family Counseling Program on Anxiety and Conscious Awareness Levels
Status: COMPLETED
Conditions: Anxiety|Awareness|Family Therapy|Cognitive Behavioral Therapy
Interventions: BEHAVIORAL: Cognitive Behavioral Model-Based Family Counseling Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Best Cutoff Value of Lactate Concentration in Vaginal Fluid to Predict Time of Spontaneous Onset of Labor in PPROM
Status: UNKNOWN
Conditions: Aim is to Investigate Association Between Lactate Concentration in Vaginal Fluid and Time of Spontaneous Onset of Labor in PPROM
Interventions: DIAGNOSTIC_TEST: Lactate concentration in vaginal fluid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study in Healthy Participants Investigating the Safety, Tolerability and Plasma Pharmacokinetics (PK) of Single Oral Doses of JNJ-47910382
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: JNJ-47910382|DRUG: JNJ-47910382|DRUG: JNJ-47910382|DRUG: JNJ-47910382|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT