pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Baked Milk Oral Immunotherapy for Cow's Milk Allergy
Status: COMPLETED
Conditions: Cow's Milk Allergy
Interventions: DRUG: Baked non-fat cow's milk powder|DRUG: Placebo: Tapioca Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PET Imaging of Solid Tumors Using 124I-Humanized 3F8: A Pilot Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma|Neuroblastoma|Sarcoma
Interventions: BIOLOGICAL: 124I-Humanized 3F8
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Lopinavir/r or Fosamprenavir/r Switch to Atazanavir/r or Darunavir/r
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: ATV/r|DRUG: DRV/r
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II a Study of Lenvatinib, a Multi-targeted Tyrosine Kinase Inhibitor, Combined With Pembrolizumab (PD-1 Inhibitor) for the Treatment of Metastatic Gastroesophageal Cancer Patients Who Have Progressed on First or Subsequent Line Therapies
Status: COMPLETED
Conditions: GastroEsophageal Cancer|Gastric Cancer
Interventions: DRUG: Lenvatinib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of McGrath Videolaryngoscope, Pentax Airway Scope and Macintosh Laryngoscope in Manikin by Novice
Status: COMPLETED
Conditions: Intubation
Interventions: OTHER: McGrath videolaryngoscopy|OTHER: Pentax videolaryngoscopy|OTHER: Macintosh laryngoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection Using cGMP
Status: COMPLETED
Conditions: Shigella
Interventions: BIOLOGICAL: CVD 1208S, a Shigella flexneri 2a live, oral vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Artificial Tears to Prevent Nasolacrimal Duct Obstruction in Patients Treated With Radioactive Iodine for Thyroid Cancer
Status: RECRUITING
Conditions: Nasolacrimal Duct Obstruction|Thyroid Cancer
Interventions: DRUG: Artificial Tears Methylcellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of Ftortiazinon in the Treatment of Patients With Complicated Urinary Tract Infections Caused by P. Aeruginosa
Status: UNKNOWN
Conditions: Patients With Complicated Urinary Tract Infections Caused by P. Aeruginosa|Pseudomonas Aeruginosa|Pseudomonas Infections|Urinary Tract Infections
Interventions: DRUG: Ftortiazinon (tablets 300 mg) 1/2 dose +placebo+ Maxipim|DRUG: Ftortiazinon (tablets 300 mg) full dose + Maxipim|OTHER: placebo+Maxipim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Live Attenuated ChimeriVax™-Japanese Encephalitis Vaccine
Status: COMPLETED
Conditions: Japanese Encephalitis
Interventions: BIOLOGICAL: Live attenuated Japanese encephalitis virus|BIOLOGICAL: Live attenuated Japanese encephalitis virus|BIOLOGICAL: Live attenuated Japanese encephalitis virus|BIOLOGICAL: ChimeriVax™ diluent (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Non-drug Treatment Study in Parkinson's Disease Patients and Healthy Volunteers to Collect Biological Samples in Order to Assess ex Vivo the Activity of Candidate Therapies and Develop Novel Analytical Methods for Biomarkers
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: Blood sample collection and an optional cerebrospinal fluid (CSF) collection|OTHER: Blood sample collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wearable Technological Device Applied to Patients With Chronic Pain
Status: COMPLETED
Conditions: Neck Pain|Low Back Pain|Chronic Pain|Musculoskeletal Pain
Interventions: DEVICE: Exopulse Molli-Suit (Wearable Technological Device)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Cranberry Capsules for Urinary Tract Infection Prevention in Nursing Home Residents
Status: COMPLETED
Conditions: Bacteriuria
Interventions: DIETARY_SUPPLEMENT: 2 cranberry capsules|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Non-Incised Papillae Surgical Approach (NIPSA) With and Without Graft
Status: COMPLETED
Conditions: Periodontitis|Periodontal Diseases|Periodontal Pocket|Periodontal Attachment Loss
Interventions: PROCEDURE: Non-incised papila surgical approach without grafting biomaterial|PROCEDURE: Non-incised papila surgical approach with grafting biomaterial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Effectiveness of Child-oriented Goal-setting in Paediatric Rehabilitation (the ENGAGE Approach)
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Neurodevelopmental Disorders|Cerebral Palsy
Interventions: BEHAVIORAL: ENGAGE approach (child-oriented goal-setting)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Of Blow Bottle Positive Expiratory Pressure (BBPEP) Versus Acapella Among Patient With Chronic Bronchitis
Status: COMPLETED
Conditions: Chronic Bronchitis
Interventions: DEVICE: blow bottle positive expiratory pressure|DEVICE: acapella
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Immunogenetic Profiling of Dupilumab for the Treatment of Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis|Atopic Dermatitis Eczema|Eczema|Atopic Dermatitis and Related Conditions
Interventions: DRUG: Dupilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindset Intervention for Nicotine Dependence
Status: COMPLETED
Conditions: Psychology, Social|Smoking Cessation|Smoking (Tobacco) Addiction
Interventions: BEHAVIORAL: Growth Mindset|BEHAVIORAL: SmartQuit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Evaluate the Safety, Tolerability, and Immunogenicity of AFX3772 Vaccine in Healthy Infants
Status: RECRUITING
Conditions: Pneumonia, Bacterial|Pneumococcal Infections|Pneumonia, Pneumococcal
Interventions: BIOLOGICAL: Prevnar 13|BIOLOGICAL: AFX3772
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Geriatric Assessment at Discharge From the Intensive Care Unit in Patients Aged 75 Years and Older: a Feasibility Study
Status: NOT_YET_RECRUITING
Conditions: Critical Illness|Geriatric Assessment|Older People|Frailty
Interventions: OTHER: Geriatric assessment in the 7 days following ICU discharge.|OTHER: No geriatric assessment in the 7 days following ICU discharge.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Advanced Analgesia on the Quality of Recovery After General Anesthesia in Elderly Patients
Status: RECRUITING
Conditions: General Anesthetics，Emergence Agitation
Interventions: DRUG: Nalbuphine，dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetic Study of Primaquine and Pyronaridine-Artesunate in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Primaquine and Pyronaridine-artesunate|DRUG: Primaquine and Pyronaridine-Artesunate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Somato-sensory Reflex Arch in Spinal Cord Injury - Effect on Clinical Outcome
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: PROCEDURE: Somatosensory reflex arch (Xiao Procedure)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Food Matrices Based on Fruit Pastes as Vectors of Carbohydrates for the Prevention and Management of Protein-energy Undernutrition in the Elderly (Fruisenior)
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: fruit paste matrice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Vaccination With Lethally Irradiated Glioma Cells Mixed With GM-K562 Cells in Patients Undergoing Craniotomy For Recurrent Tumor
Status: COMPLETED
Conditions: Glioma
Interventions: BIOLOGICAL: GM-K562 Vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open, Uncontrolled Study of GK567 in the Deodorization of Malodorous Fungating Neoplastic Tumours
Status: COMPLETED
Conditions: Malodorous Infected Cutaneous Ulcer
Interventions: DRUG: GK567
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Daratumumab in Treating Patients With Muscle Invasive Bladder Cancer or Metastatic Kidney Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Bladder Urothelial Carcinoma|Clear Cell Renal Cell Carcinoma|Malignant Urinary System Neoplasm|Metastatic Kidney Carcinoma|Stage IV Renal Cell Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|BIOLOGICAL: Daratumumab|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Metastasectomy|PROCEDURE: Nephrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Idelalisib and Rituximab in Elderly Patients With Untreated CLL or SLL
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia (CLL)|Small Lymphocytic Lymphoma (SLL)
Interventions: DRUG: Idelalisib|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of BAY73-4506 in Chinese Patients With Advanced, Refractory Solid Tumors
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Regorafenib (Stivarga, BAY73-4506)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of a Single Dose of Pretomanid Added to an Optimized Background Regimen in Children With Rifampicin-Resistant Tuberculosis
Status: RECRUITING
Conditions: Tuberculosis|Rifampicin Resistant Tuberculosis
Interventions: DRUG: Pretomanid|DRUG: Optimized background regimen (OBR) for multidrug-resistant TB (MDR-TB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Adult Glioblastoma (IMPACT)
Status: RECRUITING
Conditions: Glioblastoma Multiforme|Glioblastoma
Interventions: BIOLOGICAL: Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effectiveness of Piscean Derived Collagen Dressing on Neuropathic Diabetic Foot Ulcer in T2DM Patients
Status: COMPLETED
Conditions: Diabetic Foot Ulcer Neuropathic|Diabetic Foot Ulcer
Interventions: DEVICE: Piscean collagen dressing|DEVICE: Saline infused dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Safety and Efficacy Study of Taliglucerase Alfa in Subjects With Type 3 Gaucher Disease
Status: COMPLETED
Conditions: Gaucher Disease, Type 3
Interventions: DRUG: Elelyso
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Crossover of NAVA and Synchronized Intermittent Pressure Ventilation in Neonates and Infants
Status: COMPLETED
Conditions: Respiratory Insufficiency|Infant, Newborn, Disease
Interventions: DEVICE: Neurally Adjusted Ventilatory Assist|DEVICE: Synchronized Interm. Mandatory Assist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Cost Effectiveness of ACE Inhibitor, Ramipril, in Intermittent Claudicants
Status: COMPLETED
Conditions: Intermittent Claudicants
Interventions: DRUG: Ramipril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Social Incentives To Encourage Physical Activity and Understand Predictors
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Supportive social incentive|BEHAVIORAL: Competitive social incentive|BEHAVIORAL: Collaborative social incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: ALS Reversals - Lunasin Regimen
Status: COMPLETED
Conditions: ALS (Amyotrophic Lateral Sclerosis)
Interventions: DRUG: Lunasin Regimen|OTHER: Historical control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Tadalafil Once-a Day for 12 Weeks in Men With Signs and Symptoms of Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: tadalafil|DRUG: tadalafil|DRUG: tadalafil|DRUG: tadalafil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tacrolimus Plus Glucocorticoid for Severe Thrombocytopenia in SS
Status: NOT_YET_RECRUITING
Conditions: Sjogren Syndrome With Other Organ Involvement
Interventions: DRUG: Prednisolone|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Plyometric Training on University Female Tennis Players' Physical Fitness and Serve Performance
Status: COMPLETED
Conditions: Physical Illness|Skill, Coping
Interventions: OTHER: Plyometric training|OTHER: Routine training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transversalis Fascial Plane Nerve Block in Iliac Crest Bone Graft
Status: COMPLETED
Conditions: Upper Limb Surgery|Iliac Crest Bone Harvest
Interventions: DRUG: Active treatment|DRUG: Placebo Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Sedatives on Tobacco Use Disorder Version 2
Status: RECRUITING
Conditions: Tobacco Smoking
Interventions: DRUG: Ketamine|DRUG: Midazolam|DRUG: Dexmedetomidine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Is a Front-of-package Label Contaning Information on Both Nutrient Profile and Ultra-processing Well Understood?
Status: COMPLETED
Conditions: Objective Understanding of Nutritional Label
Interventions: OTHER: Front-of-pack label NutriScore 2.0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Dexmedetomidine and Liver Transplantation
Status: COMPLETED
Conditions: Dexmedetomidine, Liver Transplantation, Allograft Function, Survival
Interventions: DRUG: Dexmedetomidine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LDL-cholesterol Lowering Effect of a New Dietary Supplement
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: Argicolina|DIETARY_SUPPLEMENT: Normolip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Efficacy of MK-8521 Compared to Placebo and a Diabetes Drug in Participants With Type 2 Diabetes Mellitus (MK-8521-003)
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: MK-8521|DRUG: Liraglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy for Patients With Gastroesophageal Cancers Who Have Progressed After One Prior Chemo Regimen
Status: TERMINATED
Conditions: Esophageal|Gastrooesophageal Cancer|Gastric Cancer
Interventions: DRUG: jevtana
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Two Probiotic Preparations in Children With Acute Diarrhoea
Status: WITHDRAWN
Conditions: Gastroenteritis
Interventions: DIETARY_SUPPLEMENT: Saccharomyces boulardii|DIETARY_SUPPLEMENT: Probiotics combination|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Norwegian World Health Organisation Labour Care Guide Trial (NORWEL)
Status: NOT_YET_RECRUITING
Conditions: Labor Dystocia|Labor Complication|Labor Onset and Length Abnormalities|Labor (Obstetrics)--Complications|Experience, Life|Progression|Cesarean Section Complications|Apgar; 4-7 at 1 Minute
Interventions: OTHER: the labour care guide (LCG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy in Treating Patients Who Have Undergone Surgery for Newly Diagnosed Grade II or Grade III Meningioma
Status: UNKNOWN
Conditions: Brain and Central Nervous System Tumors
Interventions: PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: ABC Trial: Awakening and Breathing Controlled
Status: COMPLETED
Conditions: Aging|Respiration, Artificial
Interventions: PROCEDURE: SAT: Spontaneous Awakening Trial|PROCEDURE: SBT: Spontaneous Breathing Trial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemoradiation With RHUMAB VEGF (Avastin) for Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DRUG: Avastin (Bevacizumab, RHUMAB VEGF)|DRUG: Capecitabine|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Randomized, Double-Blind, Placebo-Controlled, Parallel Group Clinical Study of ICP-332 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: ICP-332|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Xylitol Syrup for the Prevention of Acute Otitis Media in Otitis-prone Children
Status: COMPLETED
Conditions: Acute Otitis Media
Interventions: DRUG: Xylitol syrup|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Post Operative Adjuvant Chemotherapy Followed by Adjuvant Tamoxifen vs Nil for Patients With Operable Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: to Investigate the Pharmacokinetic Interactions and Safety Between Rosuvastatin and Ezetimibe in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Crestor+Ezetrol|DRUG: Ezetrol|DRUG: Crestor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study Comparing Naltrexone SR/Bupropion SR and Placebo in Obese Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Obesity|Overweight|Diabetes Mellitus, Type 2
Interventions: DRUG: Naltrexone SR 32 mg/bupropion SR 360 mg/ day|DRUG: Placebo|BEHAVIORAL: Ancillary therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Neoadjuvant Durvalumab (D) and Platinum-Based Chemotherapy (CT), Followed by Either Surgery and Adjuvant D or CRT and Consolidation D, in Resectable or Borderline Resectable Stage IIB-IIIB NSCLC (MDT-BRIDGE)
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Corneal Endothelium After Phacoemulsification in Pseudo Exfoliation Syndrome
Status: COMPLETED
Conditions: Corneal Endothelial Cell Loss|Pseudoexfoliation Syndrome
Interventions: PROCEDURE: phacoemulsification
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Radical Treatment of Synchronous Oligometastatic Non-Small Cell Lung Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung|Synchronous Neoplasms
Interventions: OTHER: First line systemic treatment|OTHER: Radical treatment|RADIATION: radiation therapy|OTHER: Chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: N2004-03: Intravenous Fenretinide in Treating Young Patients With Recurrent or Resistant Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: DRUG: fenretinide|OTHER: high performance liquid chromatography|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine Combined With Gemcitabine in the Treatment of Advanced Non-small Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Hydroxychloroquine|Gemcitabine|Lung Neoplasms
Interventions: DRUG: Hydroxychloroquine Combined With Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TOBY (TOtal Body hYpothermia): a Study of Treatment for Perinatal Asphyxia
Status: COMPLETED
Conditions: Asphyxia Neonatorum|Hypoxia|Encephalopathy|Seizures
Interventions: PROCEDURE: Whole body mild induced hypothermia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Femoral Nerve Block on Postoperative Opioid Use After Anterior Cruciate Ligament (ACL) Reconstruction
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: PROCEDURE: Administration of a femoral nerve block (bupivacaine HCL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: FFR or OCT Guidance to RevasculariZe Intermediate Coronary Stenosis Using Angioplasty
Status: UNKNOWN
Conditions: Ischemic Heart Disease
Interventions: DEVICE: FFR guided PCI|DEVICE: OCT guided PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nonpolymer- and Polymer-Based Drug-Eluting Stents for Restenosis (ISAR-TEST-1)
Status: COMPLETED
Conditions: Coronary Disease
Interventions: DEVICE: Paclitaxel-eluting stent (Taxus)|DEVICE: Rapamycin-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Adults to Test the Effects of Low Dose Thimerosal on Symptoms of COVID-19
Status: COMPLETED
Conditions: SARS-CoV-2 Infection
Interventions: DRUG: BTL-TML-COVID|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Levosimendan in Acute Kidney Injury Study
Status: UNKNOWN
Conditions: Acute Kidney Injury
Interventions: DRUG: Levosimendan|DRUG: Conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Neuromodulation on Language Impairments in Stroke Patients
Status: COMPLETED
Conditions: Stroke|Aphasia
Interventions: DEVICE: tDCS|BEHAVIORAL: Speech and language therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY2140023 in Healthy Males and Females
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: LY2140023 Reference form|DRUG: LY2140023 Test-Low|DRUG: LY2140023 Test-Medium|DRUG: LY2140023 Test-High
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension to Study 200952 to Evaluate the Long-term Safety, Tolerability and Pharmacodynamics of Albiglutide Liquid Drug Product in Type 2 Diabetes Mellitus Subjects
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Albiglutide|DEVICE: Auto-injector
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy and Safety of Empegfilgrastim for Neutropenia Prophylaxis in Breast Cancer Patients
Status: COMPLETED
Conditions: Chemotherapy-induced Neutropenia
Interventions: BIOLOGICAL: Empegfilrastim 6 mg|BIOLOGICAL: Filgrastim|BIOLOGICAL: Placebo №1|BIOLOGICAL: Placebo №2|BIOLOGICAL: Empegfilrastim 7.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy Study of a Eye Drop for Eye Allergy
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: alcaftadine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Extracorporal Shock Wave Therapy in Patient With Chronic Non-bacterial Prostatitis / Chronic Pelvic Pain Syndrome
Status: UNKNOWN
Conditions: Extracorporal Shock Wave Therapy|Chronic Non-bacterial Prostatitis|Chronic Pelvic Pain Syndrome
Interventions: DEVICE: standars electromagnetic DUOLITH SD1|DEVICE: turn off standars electromagnetic DUOLITH SD1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Acute Heart Failure With Preserved Ejection Fraction - COngestion Discharge Evaluation
Status: RECRUITING
Conditions: Acute Heart Failure
Interventions: PROCEDURE: Clinical examination centered on congestion|PROCEDURE: Cardio-pulmonary, peritoneal, jugular and renal Doppler ultrasounds and liver elastography|PROCEDURE: Biological: Blood sample retrieved for biological assessment and biobanking|PROCEDURE: Telephone interview|BEHAVIORAL: Kansas City Cardiomyopathy Questionnaire (KCCQ)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: TGR-1202 + Ruxolitinib PMF PPV-MF PET-MF MDS/MPN Polycythemia Vera Resistant to Hydroxyurea
Status: COMPLETED
Conditions: Myelofibrosis|Polycythemia Vera
Interventions: DRUG: TGR-1202|DRUG: ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supporting Tailored And Responsive PrEP in Rural North Carolina
Status: RECRUITING
Conditions: HIV Pre-Exposure Prophylaxis
Interventions: OTHER: PrEP Navigation Services|OTHER: Telehealth PrEP Services Referral|BEHAVIORAL: HealthMpowerment Digital Health Intervention - Enhanced|BEHAVIORAL: HealthMpowerment Digital Health Intervention - Basic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Utility of ESI in Presurgical Evaluation of Patients With Epilepsy
Status: COMPLETED
Conditions: Electroencephalography|Refractory Epilepsy|Brain Imaging|Surgery
Interventions: DIAGNOSTIC_TEST: Low-density ESI (LD ESI)|DIAGNOSTIC_TEST: High-density ESI (HD ESI)|DIAGNOSTIC_TEST: No electrical source imaging (ESI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Using the Drug Thalidomide to Stimulate T Cells in HIV-Infected People
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Thalidomide|DRUG: Thalidomide placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Nitazoxanide as a New Local Adjunctive to Nonsurgical Treatment of Moderate Periodontitis
Status: COMPLETED
Conditions: Periodontitis
Interventions: PROCEDURE: Scaling and Root Planing|DRUG: Nitazoxanide hydrogel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Study of Postoperative Adjuvant Chemotherapy of Uracil- Tegafur (UFT) Compared With Surgery Alone (NSAS-CC)
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: UFT (uracil, tegafur)|PROCEDURE: Surgery alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methylphenidate for the Treatment of Gait Impairment in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease|Gait Impairment
Interventions: DRUG: Methylphenidate (MPD)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-Dose Stereotactic Radiation for Prostate Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Prostate|Recurrent Prostate Cancer|Stage I Prostate Cancer|Stage IIA Prostate Cancer|Stage IIB Prostate Cancer|Stage III Prostate Cancer
Interventions: RADIATION: stereotactic body radiation therapy|PROCEDURE: quality-of-life assessment|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Administration of Mesenchymal Stem Cells in Patients With Chronic Ischemic Cardiomyopathy (MESAMI2)
Status: COMPLETED
Conditions: Chronic Myocardial Ischemia
Interventions: DRUG: Autologous MSC from bone marrow|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Olanzapine in the Extended Treatment for Manic or Mixed Episode of Bipolar I Disorder
Status: COMPLETED
Conditions: Manic or Mixed Episode Associated With Bipolar I Disorder
Interventions: DRUG: olanzapine|DRUG: lithium|DRUG: valproate|DRUG: carbamazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Response After Stem Cell Transplant in HIV-Positive Patients With Hematologic Cancer
Status: COMPLETED
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|HIV Infection
Interventions: OTHER: Laboratory Biomarker Analysis|PROCEDURE: Leukapheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Low-dose Ketamine to Opioids in the Management of Acute Pain in Patients Presenting to the Emergency Department With Long Bone Fractures
Status: WITHDRAWN
Conditions: Pain, Acute
Interventions: DRUG: Ketamine|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preemptive Oral Gabapentin 600 mg in Reducing Morphine Requirement After Non Obstetric Lower Abdominal Surgery
Status: COMPLETED
Conditions: Non-obstetric Lower Abdominal Surgery
Interventions: DRUG: Gabapentin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Versus Non-Guided Prolotherapy for Internal Derangement of Temporomandibular Joint.
Status: RECRUITING
Conditions: TMJ Disc Disorder|Ultrasound Therapy; Complications|TMJ|Prolotherapy|Internal Derangement|Clicking Tinnitus|Injection Site|Pain, Chronic|Anterior Disc Displacement|Myofascial Pain Syndrome|Masticatory Muscle
Interventions: PROCEDURE: Prolotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Solriamfetol and CBT-I in Patients With Insomnia Disorder
Status: RECRUITING
Conditions: Insomnia
Interventions: DRUG: Solriamfetol 75 MG|BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia (CBT-I)|OTHER: Monitoring|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Musculoskeletal Ultrasound Assessment of Therapeutic Response of Tofacitinib in Rheumatoid Arthritis Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: tofacitinib 5mg po bid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Perioperative Administration of Intravenous Lidocaine in Children Operated on for Acute Generalized Peritonitis
Status: NOT_YET_RECRUITING
Conditions: Postoperative Pain
Interventions: DRUG: Lidocaine intravenous|DRUG: Serum saline intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effects of NNC0194-0499, Cagrilintide, and Semaglutide Alone or in Combinations on Liver Damage and Alcohol Use in People With Alcohol-related Liver Disease
Status: RECRUITING
Conditions: Alcohol-related Liver Disease
Interventions: DRUG: NNC0194-0499|DRUG: Semaglutide|DRUG: NNC0194-0499 placebo|DRUG: Semaglutide placebo (Group A)|DRUG: Cagrilintide + semaglutide|DRUG: Cagrilintide|DRUG: Cagrilintide placebo|DRUG: Semaglutide placebo (Group B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Radial Artery Occlusion After Trans-radial Cardiac Catheterization
Status: UNKNOWN
Conditions: CARDIAC CATHETRIZATION
Interventions: DEVICE: ulnar artery compression device|DEVICE: radial artery compression device guided with plysthmography|DEVICE: radial artery compression device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomised Control Clinical Trial Investigating the Effect of H-PRF on Implant Stability and Marginal Bone Levels
Status: RECRUITING
Conditions: Osseointegration Failure of Dental Implant
Interventions: BIOLOGICAL: Horizontal platelet-rich fibrin (H-PRF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety, Tolerability, Plug Retention and Preliminary Efficacy of Tacrolimus-loaded Punctal Plug in Patients With Moderate to Severe Dry Eye Disease - Cohort B
Status: ACTIVE_NOT_RECRUITING
Conditions: Dry Eye|Keratoconjunctivitis Sicca|Ocular Inflammation
Interventions: DEVICE: punctum plug insertion|DRUG: Eye Drops, Lubricant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Intravenous Rexin-G in Osteosarcoma
Status: COMPLETED
Conditions: Osteosarcoma
Interventions: GENETIC: Rexin-G Dose 1|GENETIC: Rexin-G Dose 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Orleans Pulmonary Hypertension Biobank
Status: RECRUITING
Conditions: Pulmonary Hypertension|Systemic Sclerosis|Mixed Connective Tissue Disease|Heart Failure With Normal Ejection Fraction|Healthy
Interventions: OTHER: No intervention. Biospecimen collection only
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Avastin (Bevacizumab) Added to Interferon Alfa-2a (Roferon) Therapy in Patients With Metastatic Renal Cell Cancer With Nephrectomy
Status: COMPLETED
Conditions: Renal Cell Cancer
Interventions: DRUG: Bevacizumab [Avastin]|DRUG: Interferon alfa 2a [Roferon]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Canine Retraction Using Ni-ti Closed-coil Springs Vs Elastomeric Power Chains During Orthodontic Treatment
Status: NOT_YET_RECRUITING
Conditions: Root Resorption|Plaque Accumulation|Gingivitis
Interventions: OTHER: Ni-ti Closed-coil Spring|OTHER: Elastomeric Power chain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Structured Comprehensive Intervention to Stimulate Self- Management and Improve Quality of Life in COPD Patients
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: COPD structured self-management plan.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Retrospective Study of COVID-19 Treatments
Status: COMPLETED
Conditions: Covid19|COVID-19 Pneumonia|COVID-19 Respiratory Infection|COVID-19 Acute Bronchitis|COVID-19 Acute Respiratory Distress Syndrome|COVID-19 Lower Respiratory Infection|SARS-CoV2 Infection|SARS-CoV-2 Acute Respiratory Disease
Interventions: OTHER: No Intervention Used
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pilot Study of mDOT for Immunosuppressant Adherence in Adult Liver Transplant Recipients
Status: WITHDRAWN
Conditions: Medication Adherence|Liver Transplant
Interventions: OTHER: mHealth Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Corneal Protect Used During Cataract Surgery
Status: UNKNOWN
Conditions: Cataract
Interventions: DEVICE: Hydroxypropyl ethylcellulose (HPMC) 2% gel|DEVICE: BSS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 1, Open-label, Dose Escalation Study of TRC093, in Patients With Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Cancer|Neoplasm Metastasis
Interventions: DRUG: TRC093 recombinant humanized IgG1k monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Two Formulations of Biphasic Insulin Aspart 50 in Healthy Japanese Subjects
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart 50
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sunitinib Followed by Avelumab or the Reverse for Metastatic Renal Cell Carcinoma
Status: WITHDRAWN
Conditions: Clear-cell Renal Cell Carcinoma|RCC|Kidney Cancer|Clear-cell Kidney Carcinoma
Interventions: DRUG: Avelumab|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Claudin 18.2-Targeted Chimeric Antigen Receptor T-cells in Subjects With Unresectable, Locally Advanced, or Metastatic Gastric, Gastroesophageal Junction (GEJ), Esophageal, or Pancreatic Adenocarcinoma
Status: RECRUITING
Conditions: Gastric Cancer|Gastroesophageal-junction Cancer|Esophageal Cancer|Pancreatic Cancer
Interventions: BIOLOGICAL: LB1908
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Dry Needling in Linear Scar Tissue
Status: RECRUITING
Conditions: Scar Tissue|Hypertrophic Scar|Hypertrophic Scar of Upper Arm (Disorder)|Hypertrophic Surgical Scar|Dry Needling
Interventions: OTHER: True dry needling|OTHER: Sham dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Air Abrasion Surface Pretreatment in the Repairing Capacity of Defective Composite Restoration
Status: COMPLETED
Conditions: Repair
Interventions: DEVICE: Air abrasion sandblasting aluminum oxide particles (Al2O3) AquaCare single (Velopex, Medivance Instruments Ltd., London, UK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Alpha-blockers Alone During Preoperative Preparation in Patients With Pheochromocytoma
Status: COMPLETED
Conditions: Adrenal Pheochromocytoma|Hemodynamic
Interventions: DRUG: Abandonment of intravenous volume expansion during preoperative preparation in patients with pheochromocytoma
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomized Trial Evaluating Personalized vs Guideline-based Well Follow-up Strategies for Patients With Early-stage Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: OTHER: On-demand personalized follow-up care|OTHER: Guideline-based follow-up care (standard of care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intermediate-size Expanded Access Program (EAP), Mesenchymal Stromal Cells (MSC) for Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19 Infection
Status: NO_LONGER_AVAILABLE
Conditions: Moderate to Severe Acute Respiratory Distress Syndrome Associated With COVID-19
Interventions: DRUG: Remestemcel-L
Study Type: EXPANDED_ACCESS
Clinical trial: Internal Hernias After Gastric Bypass Can be Prevented Safely With Primary Closure of All Mesenteric Defects With Clips
Status: UNKNOWN
Conditions: Internal Hernias
Interventions: PROCEDURE: Closing the mesenteric defects with clips during opration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on the Deep Remission of Rheumatoid Arthritis With Kidney Deficiency and Excessive Cold Syndrome by Bushen Quhan Zhiwang Decoction
Status: NOT_YET_RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Bushen quhan zhiwang decoction|DRUG: Bushen quhan zhiwang decoction placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Immunotherapy With Tavo + Electroporation in Combination With Nivo. in Melanoma Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: DRUG: Tavo|DRUG: Nivolumab|DEVICE: OncoSec Medical Electroporation Therapy System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT