pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Atorvastatin Calcium, Oligofructose-Enriched Inulin, or Sulindac in Preventing Cancer in Patients at Increased Risk of Developing Colorectal Neoplasia
Status: COMPLETED
Conditions: Colon Cancer|Precancerous Condition|Rectal Cancer
Interventions: DRUG: oligofructose-enriched inulin|DRUG: sulindac|DRUG: placebo|DRUG: atorvastatin calcium|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Multiple Dose Safety Study of PF-04802540 in Subjects With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: PF-04802540|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Multi-center Trial to Evaluate Multiple Regimens in Metastatic Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Pancreatic Cancer|Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: Gemcitabine combined with nab-paclitaxel|DRUG: Dose -mFOLFIRINOX|DRUG: Dose - Pamrevlumab combined with gemcitabine and nab-paclitaxel|DRUG: Dose- Canakinumab and Spartalizumab combined with nab-paclitaxel and gemcitabine|DRUG: Drug: Dose -SM-88
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Oral DMT Burden and Adherence in MS
Status: ENROLLING_BY_INVITATION
Conditions: Multiple Sclerosis|Adherence, Medication
Interventions: DRUG: Cladribine|DRUG: Dimethyl fumarate|DRUG: Fingolimod|DRUG: Teriflunomide|DRUG: Ozanimod|DRUG: Diroximel fumarate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preventive Effect of Enoxaparin, Pentoxifylline and Ursodeoxycholic Acid to Radiation Induced Liver Toxicity
Status: COMPLETED
Conditions: Colorectal Cancer|Liver Metastases|Irradiation Damage|Radiation Induced Liver Disease
Interventions: DRUG: Pentoxifylline|DRUG: Ursodeoxycholic Acid|DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Low Level Laser Therapy Effects in Peripheral Nerves Patient With Leprosy.
Status: UNKNOWN
Conditions: Leprosy Neuropathy
Interventions: DEVICE: LLLT|DEVICE: Sham LLLT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Estrogen in the Neurobiology of Eating Disorders
Status: RECRUITING
Conditions: Eating Disorders|Hypoestrogenemia
Interventions: DRUG: 17-β estradiol transdermal patches with cyclic progesterone|DRUG: Placebo patch and pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Flavanol-rich Dark Chocolate Consumption on Metabolic Profiles Among Obese Adults Using Metabolomics Approach
Status: UNKNOWN
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Dark chocolate (20 grams) per day providing 508 mg of polyphenols|DIETARY_SUPPLEMENT: white chocolate (20 grams) with no polyphenols
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Accuracy of Placental Thickness in Lower Uterine Segment Measured By Ultrasound in Prediction of Placenta Accreta Spectrum in Patients With Placenta Previa. A Diagnostic Test Accuracy Study
Status: COMPLETED
Conditions: Placenta Accreta Spectrum
Interventions: DIAGNOSTIC_TEST: Ultrasound measurment of placental thickness
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the Fexinidazole
Status: COMPLETED
Conditions: Human African Trypanosomiasis
Interventions: DRUG: Fexinidazole/Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Changes of Tear-film Lipid Layer Thickness and Ocular Aberration After Treatment of Meibomian Gland Dysfunction
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction
Interventions: DRUG: Treatment of Meibomian gland dysfunction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Supplementation to Increase Serum Choline Levels
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Phosphatidylcholine|DIETARY_SUPPLEMENT: Betaine (588 mg qam and 412 mg qpm)|DIETARY_SUPPLEMENT: Betaine (1000 mg BID)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluating the Safety and Pharmacokinetics of Maraviroc in HIV-1-Exposed Infants at Risk of Acquiring HIV-1 Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Maraviroc|DRUG: Maraviroc
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Pharmacokinetics of Rocaltrol When Administered Alone or in Combination With Fosrenol or Renvela in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Calcitriol|DRUG: Lanthanum carbonate + Calcitriol|DRUG: Sevelamer carbonate + Calcitriol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Doxycycline for Hereditary Hemorrhagic Telangiectasia
Status: ACTIVE_NOT_RECRUITING
Conditions: Hereditary Hemorrhagic Telangiectasia (HHT)
Interventions: DRUG: Doxycycline Hyclate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Migraine Induction Properties of PACAP-38 After Eptinezumab in Migraine Without Aura Patients.
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Eptinezumab|DRUG: PACAP-38
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison of Craniocervical Flexion and Scapular Stabilization Exercises in Forward Head Posture and Neck Pain
Status: COMPLETED
Conditions: Cervical Pain
Interventions: OTHER: Craniocervical flexion exercises|OTHER: Scapular stabilization exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pacifiers and Breastfeeding Among Mothers at Risk for Postpartum Depression
Status: WITHDRAWN
Conditions: Breastfeeding|Postpartum Depression
Interventions: OTHER: Pacifier
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Head & Neck Cancer With Chemotherapy and Radiation
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: Bevacizumab|DRUG: Erlotinib|DRUG: Paclitaxel|DRUG: 5-FU|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platform Trial Evaluating Safety and Efficacy of BI 754091 Anti- PD-1 Based Combination Therapies in PD-(L)1 naïve and PD- (L)1 Pretreated Patient Populations With Advanced/Metastatic Solid Tumours
Status: ACTIVE_NOT_RECRUITING
Conditions: Neoplasm Metastasis
Interventions: DRUG: BI 754091|DRUG: BI 754111|DRUG: BI 836880
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Restylane and Perlane in the Correction of Peri-Oral Wrinkles
Status: COMPLETED
Conditions: Peri-oral Wrinkles
Interventions: DEVICE: Restylane and Perlane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Margetuximab Plus Chemotherapy in the Treatment of Chinese Patients With HER2+ MBC
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer Metastatic
Interventions: DRUG: Margetuximab|DRUG: Trastuzumab|DRUG: Chosen Chemotherapy (Capecitabine)|DRUG: Chosen Chemotherapy (Vinorelbine )|DRUG: Chosen Chemotherapy (Gemcitabine )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epoetin Beta in Patients Undergoing Chemotherapy for Solid Tumors
Status: TERMINATED
Conditions: Anemia|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: epoetin beta|DRUG: systemic chemotherapy|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Patients With Relapsed or Refractory CD19+ Lymphoid Disease With T Cells Expressing a Third-generation CAR
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia, Adult|Acute Lymphoblastic Leukemia, Pediatric|Chronic Lymphocytic Leukemia|Diffuse Large B Cell Lymphoma|Follicular Lymphoma|Mantle Cell Lymphoma
Interventions: BIOLOGICAL: CD19.CAR T Cells|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Ablation in Treating Patients With Unresectable Primary or Metastatic Liver Cancer
Status: TERMINATED
Conditions: Liver Cancer|Metastatic Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: PROCEDURE: computed tomography|PROCEDURE: magnetic resonance imaging|PROCEDURE: positron emission tomography|PROCEDURE: radiofrequency ablation|PROCEDURE: radionuclide imaging|PROCEDURE: ultrasound imaging|RADIATION: fludeoxyglucose F 18 (FDG-PET)|RADIATION: gadopentetate dimeglumine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Nonsurgical Periodontal Therapy on Salivary Biomarkers Related to Bone Turnover in Smoker and Nonsmoker Periodontitis Patients
Status: NOT_YET_RECRUITING
Conditions: Non Surgical Periodontal Therapy
Interventions: OTHER: nonsurgical periodontal therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Decision Support Training for Advanced Cancer Family Caregivers: The CASCADE Factorial Trial
Status: RECRUITING
Conditions: Family Members|Cancer
Interventions: BEHAVIORAL: CASCADE (CAre Supporters Coached to be Adept DEcision partners)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ph 3 Efficacy and Safety of B-VEC for the Treatment of DEB
Status: COMPLETED
Conditions: Dystrophic Epidermolysis Bullosa|Recessive Dystrophic Epidermolysis Bullosa|Dominant Dystrophic Epidermolysis Bullosa
Interventions: BIOLOGICAL: Topical Beremagene Geperpavec|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Acupuncture on Patients With Functional Dyspepsia: a Multi-center, Randomized, Waitlist-controlled Trial
Status: UNKNOWN
Conditions: Functional Dyspepsia
Interventions: DEVICE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ramelteon as an Adjunct Therapy in Non-Diabetic Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorders
Interventions: DRUG: Ramelteon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Volume Saline Injections for Achilles Tendinopathy
Status: UNKNOWN
Conditions: Achilles Tendinopathy
Interventions: PROCEDURE: Ultrasound guided injection of steroid and local anaesthetic|PROCEDURE: High volume saline injection|BEHAVIORAL: exercise programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer
Status: RECRUITING
Conditions: Oropharyngeal Cancer
Interventions: OTHER: Lymphatic Mapping with SPECT-CT|RADIATION: Ipsilateral and Contralateral Neck
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Novel Therapeutic Vaccine (EO2401) in Metastatic Adrenocortical Carcinoma, or Malignant Pheochromocytoma/Paraganglioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Adrenocortical Carcinoma|Pheochromocytoma|Paraganglioma
Interventions: BIOLOGICAL: EO2401|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Gamma-hydroxy Butyrate Versus Oxazepam in the Treatment of Alcohol Withdrawal Syndrome
Status: COMPLETED
Conditions: Alcohol Withdrawal Syndrome|Alcohol Dependence
Interventions: DRUG: Sodium Oxybate (SMO)|DRUG: Oxazepam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LLLT for Reducing Waste Circumference and Weight
Status: COMPLETED
Conditions: Weight Loss
Interventions: DEVICE: 3 Low-Level Laser Therapy Treatments Weekly|DEVICE: 2 Low-Level Laser Therapy Treatments Weekly|DEVICE: 1 Low-Level Laser Therapy Treatment Weekly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Mulberry Leaf on Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Mulberry Leaf Extract|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Neprilysin (LCZ696) on Exercise Tolerance in Patients With Heart Failure
Status: COMPLETED
Conditions: Heart Failure|Exercise Tolerance|Vasodilation|Body Composition|Muscle Strength
Interventions: DRUG: Neprilysin|DRUG: Enalapril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Aerobic Exercise Training on Collegiate eSport Team Players
Status: COMPLETED
Conditions: Screen Time|Performance Enhancing|Injury Prevention|Executive Function|Cardiovascular Training
Interventions: OTHER: Aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Oral Rinse to Reduced Expelled Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) During COVID-19 Infection
Status: UNKNOWN
Conditions: Covid19
Interventions: DRUG: Mouthwash Product|OTHER: Water rinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Linagliptin in Comparison With Glimepiride as Add on to Metformin on Postprandial Beta Cell Function, Postprandial Metabolism and Oxidative Stress in Patients With Type 2 Diabetes Mellitus
Status: UNKNOWN
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: Linagliptin|DRUG: Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Virtual Reality for Postoperative Pain Management
Status: COMPLETED
Conditions: Surgery|Pain, Postoperative|Incision|Otolaryngological Disease
Interventions: DEVICE: Smartphone|DEVICE: Virtual Reality (Oculus Quest)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Parkinson's Disease With Mild Cognitive Impairment Treated With Nicotinic Agonist Drug
Status: WITHDRAWN
Conditions: Parkinson Disease|Mild Cognitive Impairment
Interventions: DRUG: AZD0328|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Sofosbuvir Plus Velpatasvir With or Without Ribavirin in Treatment-experienced Subjects With Chronic HCV Infection
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: SOF|DRUG: VEL|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous VNS to Treat Pediatric IBD
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn Disease|Ulcerative Colitis
Interventions: DEVICE: Transcutaneous Electrical Nerve Stimulation (TENS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prescribing vs. Recommending Over-The-Counter (PROTECT) Analgesics for Patients With Postoperative Pain:
Status: RECRUITING
Conditions: Acute Pain|Surgery
Interventions: OTHER: Prescription by surgical team|OTHER: Recommendation by surgical team
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pulmonary Diffusing Capacity During Postural Postural Changes and Acute Exercise
Status: COMPLETED
Conditions: Clinical Assessments of Pulmonary Diffusing Capacity
Interventions: DIAGNOSTIC_TEST: Rest-to-exercise|DIAGNOSTIC_TEST: Sitting-to-supine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mnemonic Strategy Versus Spaced Retrieval Training in Those With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: mnemonic strategy training|BEHAVIORAL: spaced retrieval training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Endocrown Restorations Longevity Compared With Post Retained Restorations
Status: UNKNOWN
Conditions: Endodontically Treated Teeth
Interventions: DEVICE: Endocrown restoration|DEVICE: Post retained composite restoration|DEVICE: Post retained ceramic restoration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Sufentanil on the Intraoperative Hemodynamics
Status: RECRUITING
Conditions: Intraoperative Hypotension
Interventions: DRUG: Sufentanil|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of AVE5026 as Compared to Placebo for the Extended Prophylaxis of Venous Thromboembolism in Patients Having Undergone Hip Fracture Surgery
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DRUG: Open-label Semuloparin sodium|DRUG: Placebo (for Semuloparin sodium)|DRUG: Semuloparin sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vibration for Muscle Spasms After Spinal Cord Injury
Status: UNKNOWN
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Wearable EMG/Vibration device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Novel Approaches for Estimating Awake and Sleep Blood Pressure
Status: COMPLETED
Conditions: Blood Pressure
Interventions: OTHER: Unattended blood pressure measurement|OTHER: Attended blood pressure measurement|OTHER: Ambulatory blood pressure monitoring|OTHER: Home blood pressure monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact Evaluation of Large-Scale Sanitation and Hygiene Interventions
Status: UNKNOWN
Conditions: Infant Diarrhea
Interventions: BEHAVIORAL: Total Sanitation and Sanitation Marketing|BEHAVIORAL: Scaling Up Handwashing Behavior Change
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 1 Open-Label, Dose Escalation Study to Determine the Optimal Dose, Safety, and Activity of AAV2hAQP1 in Subjects With Radiation-Induced Parotid Gland Hypofunction and Xerostomia
Status: COMPLETED
Conditions: Radiation-Induced Parotid Gland Hypofunction|Xerostomia Due to Radiotherapy|Head and Neck Cancer
Interventions: DRUG: AAV2hAQP1: 1 x 10^11 vg/gland (single gland)|DRUG: AAV2hAQP1: 3 x 10^10 vg/gland (both glands)|DRUG: AAV2hAQP1: 3 x 10^11 vg/gland (single gland)|DRUG: AAV2hAQP1: 1 x 10^11 vg/gland (both glands)|DRUG: AAV2hAQP1: 1 x 10^12 vg/gland (single gland)|DRUG: AAV2hAQP1: 3 x 10^11 vg/gland (both glands)|DRUG: AAV2hAQP1: 3 x 10^12 vg/gland (single gland)|DRUG: AAV2hAQP1: 1 x 10^12 vg/gland (both glands)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adiponectin in Obese Women With T2DN and Effects by RAS Blocker
Status: COMPLETED
Conditions: Obese|Type 2 Diabetes|Diabetic Nephropathy|Glucose Metabolism|Angiotensin II Type 1 Receptor Blockers
Interventions: DRUG: losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: China Lung Cancer Screening (CLUS) Study Version 2.0
Status: UNKNOWN
Conditions: Lung Neoplasms
Interventions: DEVICE: Low Dose Computed Tomography|DEVICE: artificial intelligence (AI)|DIAGNOSTIC_TEST: autofluorescence imaging (AFI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Atomoxetine to Treat Asian Adult Patients With Attention-Deficit/Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Atomoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Teriparatide in Japanese Osteoporosis Patients
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Teriparatide|DRUG: Aspara-CA 600 mg|DRUG: Alfarol 1.0 µg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tumescent Antibiotic Delivery for Prevention of Surgical Site Infection
Status: UNKNOWN
Conditions: Surgical Site Infections|Venous Thromboembolism
Interventions: PROCEDURE: Concomitant Tumescent Antibiotic Delivery & IV Delivery|DEVICE: Subcutaneous Tumescent Infiltration|DRUG: cecefazolin and metronidazole (in a dilute solution of tumescent lidocaine, epinephrin and sodium bicarbonate in 0.9% physiologic saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Aging, Sleep, Cognitive Process
Status: COMPLETED
Conditions: BIOLOGICAL CLOCKS
Interventions: OTHER: Sleep deprivation and multiple rest|OTHER: Sleep deprivation and multiple rest|OTHER: Sleep deprivation and multiple rest|OTHER: Sleep deprivation and multiple rest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Surgical Treatment of Hip Fractures Under Peripheral Regional Anesthesia
Status: COMPLETED
Conditions: Hip Fractures
Interventions: DRUG: Ropivacaine (sciatic nerve block)|DRUG: Ropivacaine (lumbar plexus block L2-L4)|DRUG: Ropivacaine (lumbar plexus block Th12-L1)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Irbesartan/Hydrochlorothiazide Versus Valsartan/Hydrochlorothiazide in Mild to Moderate Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Irbesartan/hydrochlorothiazide|DRUG: Valsartan/hydrochlorothiazide|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Research on the Treatment of Severe Community-acquired Pneumonia in Children
Status: RECRUITING
Conditions: Severe Pneumonia
Interventions: DRUG: Prednisolone Acetate|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of Quadrivalent Influenza Virus Vaccine in Healthy People Aged Years 3-60
Status: UNKNOWN
Conditions: Quadrivalent Influenza Virus Vaccine
Interventions: BIOLOGICAL: one dose test vaccine|BIOLOGICAL: one dose commercially available trivalent influenza vaccine|BIOLOGICAL: One dose of Quadrivalent Influenza Virus Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Anti-Inflammatory Milk Matrix
Status: RECRUITING
Conditions: Obesity|Skeletal Muscle|Inflammation
Interventions: BEHAVIORAL: Controlled-Feeding Intervention|DIETARY_SUPPLEMENT: Non-dairy beverage|OTHER: Full-fat milk|OTHER: Fat-free milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for the Prevention of Emergence Delirium in Children Undergoing Myringotomy Tube Placement
Status: COMPLETED
Conditions: Delirium|Psychomotor Agitation
Interventions: OTHER: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial To Evaluate Efficacy And Safety Of Levophencynonate Hydrochloride In Patient With Vertigo
Status: COMPLETED
Conditions: Vertigo
Interventions: DRUG: Levophencynonate Hydrochloric|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PF-04995274 and Emotional Processing in Un-medicated Depression
Status: COMPLETED
Conditions: Depression, Unipolar
Interventions: DRUG: PF-04995274|DRUG: Citalopram|DRUG: Placebo Oral Tablet|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Randomized, Double-blind Controlled Study Comparing LCZ696 to Medical Therapy for Comorbidities in HFpEF Patients
Status: COMPLETED
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: sacubitril/valsartan|DRUG: Enalapril|DRUG: Valsartan|DRUG: Placebo to match sacubitril/valsartan|DRUG: Placebo to match enalapril|DRUG: Placebo to match valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Germ Cell Tumor|Teratoma|Choriocarcinoma|Germinoma|Mixed Germ Cell Tumor|Yolk Sac Tumor|Childhood Teratoma|Malignant Germ Cell Neoplasm|Extragonadal Seminoma|Non-seminomatous Germ Cell Tumor|Seminoma
Interventions: DRUG: paclitaxel|DRUG: ifosfamide|DRUG: cisplatin|DRUG: pegylated G-CSF|DRUG: G-CSF|DRUG: carboplatin|DRUG: etoposide phosphate|PROCEDURE: stem cell reinfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Uniportal VATS Versus Chest Tube for Early Empyema
Status: COMPLETED
Conditions: Empyema, Pleural
Interventions: PROCEDURE: Uniportal VATS|PROCEDURE: Tube thoracostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studying Language With Brain Stimulation in Aphasia
Status: RECRUITING
Conditions: Stroke|Aphasia
Interventions: DEVICE: Cortico-cortical paired associative stimulation|DEVICE: Sham cortico-cortical paired associative stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neodymiun:Yttrium Aluminum Garnet Laser in Caries Prevention of Primary Teeth: One-year Follow-up
Status: UNKNOWN
Conditions: Caries in Occlusal Surface of Primary and Permanent Detition
Interventions: OTHER: Laser in caries prevention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: O(6)-Benzylguanine and Carmustine in Treating Patients With Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: O6-benzylguanine|DRUG: carmustine|DRUG: chemosensitization/potentiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Antibiotic Dosing for Total Knee Arthroplasty
Status: WITHDRAWN
Conditions: Acute Infection of Total Knee Replacement
Interventions: DEVICE: New Intraosseous|DRUG: Cefazolin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Learning Crisis Resource Management: Practicing Versus Observational Role in Simulation Training
Status: COMPLETED
Conditions: Focus of Study is Teaching Crisis Resource Management
Interventions: BEHAVIORAL: observational role|BEHAVIORAL: active role
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of Therapeutic Vaccination With Intensified Schedule Plus Pegasys Dual Therapy on Chronic Hepatitis B Infection
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: BIOLOGICAL: Peginterferon alfa-2a|BIOLOGICAL: HBV vaccination|DRUG: Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics Of Jaktinib In Subjects With Hepatic Impairment And Normal Hepatic Function
Status: COMPLETED
Conditions: Hepatic Insufficiency|Healthy Subjects
Interventions: DRUG: Jaktinib Hydrochloride Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radioimmunotherapy (RIT) in MULTIPLE MYELOMA Using the Antibody B-B4 Radiolabelled With IODE 131
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: BB4 antibody-Iodine 131
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Administration of Methylprednisolone for Prevention of Ovarian Hyper Stimulation Syndrome
Status: COMPLETED
Conditions: Ovarian Hyperstimulation Syndrome
Interventions: DRUG: Methylprednisolone|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of a Local Injection of a Platelet Concentrate on Infection and Healing of Surgical Wounds
Status: UNKNOWN
Conditions: Wound Infection and Wound Healing
Interventions: OTHER: Leucocyte - Platelet rich Plasma|DIETARY_SUPPLEMENT: Vitamin C|DIETARY_SUPPLEMENT: Zinc|DIETARY_SUPPLEMENT: L-Arginine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Collagen Cross-Linking With Ultraviolet-A in Asymmetric Corneas
Status: TERMINATED
Conditions: Keratoconus|Corneal Diseases|Eye Diseases|Photosensitizing Agents
Interventions: COMBINATION_PRODUCT: CXLO Corneal Strengthening Solution and UVA Illumination Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Resection vs. Separated Resection After Mobilization of Splenic Vein During Distal Pancreatectomy
Status: UNKNOWN
Conditions: Pancreatic Neoplasms
Interventions: PROCEDURE: combined resection of the splenic vein|PROCEDURE: separated resection of the splenic vein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tenoten for Children in the Treatment of Specific Developmental Disorders of Scholastic Skills in Children
Status: COMPLETED
Conditions: Specific Developmental Disorders of Scholastic Skills
Interventions: DRUG: Tenoten for children|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of Circadian Biomarkers in Patients With Sleep Disorders
Status: COMPLETED
Conditions: Sleep Disorders, Circadian Rhythm|Circadian Rhythm Disorders|Circadian Rhythm Sleep Disorder|Advanced Sleep Phase Syndrome (ASPS)|Delayed Sleep Phase Syndrome|Sleep Wake Disorders|Sleep Disorder
Interventions: OTHER: dim light melatonin onset (DLMO)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Advanced Practice Nurse's Management of Patients With Chronic Myeloid Leukemia
Status: RECRUITING
Conditions: Chronic Myelogenous Leukemia - Chronic Phase
Interventions: OTHER: APN and medical management|OTHER: Medical management|BEHAVIORAL: Quality of life assessment|BEHAVIORAL: Treatment compliance assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Wii Fit Exercises Versus Pilates Exercises in Adult Patients With Lower Extremity Burn
Status: RECRUITING
Conditions: Burns|Muscle Weakness|Exercises|Functional Performance
Interventions: OTHER: Wii fit exercises program|OTHER: Pilates exercises program|OTHER: Standard physical therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-Dose Aldesleukin and Ipilimumab in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed By Surgery
Status: TERMINATED
Conditions: Recurrent Melanoma|Stage IIIA Melanoma|Stage IIIB Melanoma|Stage IIIC Melanoma|Stage IV Melanoma
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: ipilimumab|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of a Bladder Training Video for Management of Lower Urinary Tract Symptoms.
Status: COMPLETED
Conditions: Nonneurogenic Lower Urinary Tract Dysfunction|Dysfunctional Elimination Syndrome
Interventions: OTHER: Educational Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Safety and Efficacy of Varenicline in Patients That Wish to Stop Smoking
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: varenicline tartrate (CP-526, 555-18)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Envafolimab Combined With Trifluridine/Tipiracil and Bevacizumab in the Treatment of Refractory mCRC.
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Envafolimab|DRUG: Trifluridine/Tipiracil|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
Status: NOT_YET_RECRUITING
Conditions: Breast Carcinoma|Colorectal Carcinoma|Lung Non-Small Cell Carcinoma|Melanoma|Non-Hodgkin Lymphoma
Interventions: OTHER: Non-interventional Study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Outcome of a Patented Pharmaceutical Composition (KT-110) to Treat Alcohol Use Disorder While Avoiding Major Side Effects
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: DRUG: Cyproheptadine|DRUG: Alpress LP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Detection of Cardiac Toxicity of Trastuzumab (Herceptin ®) in Patients Treated for Breast Carcinoma: Value of Magnetic Resonance Imaging
Status: TERMINATED
Conditions: Cancer, Breast|LV Dysfunction
Interventions: OTHER: Cardiac MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase I Trial of Tamoxifen and 9-Cis-Retinoic Acid in Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer|Breast Neoplasm
Interventions: DRUG: 9-cis-Retinoic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Atrial Sensing Capability for Better Detection of Atrial Fibrillation
Status: UNKNOWN
Conditions: Implantable Cardioverter Defibrillator|Atrial Fibrillation|Cardiac Event|Cardiac Arrhythmia
Interventions: DEVICE: Atrial sensing On mode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Nutrition, Immunology and Epidemiology of Tuberculosis
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DIETARY_SUPPLEMENT: Multivitamins|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of General Anesthesia on the Middle Ear Pressure
Status: COMPLETED
Conditions: Ear Deformities, Acquired
Interventions: DRUG: desflurane,|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Propiverine Hydrochloride Extended-Release Capsule for Overactive Bladder
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: Propiverine Hydrochloride|DRUG: Tolterodine Extended-release Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Abemaciclib Neuropharmacokinetics of Diffuse Midline Glioma Using Intratumoral Microdialysis
Status: RECRUITING
Conditions: Glioma
Interventions: DRUG: pre-operative abemaciclib|DEVICE: Device for Cerebral Fluid Dialysate Collection|DEVICE: Ashion Analytics GEM ExTra|DRUG: abemaciclib + temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-Anastomosis Duodeno-Ileal Bypass With Sleeve Gastrectomy (SADI-S) for the Treatment of Morbid Obesity and Its Metabolic Complications
Status: UNKNOWN
Conditions: Morbid Obesity|Diabetes
Interventions: PROCEDURE: SADI-S 250
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reversal of Neuromuscular Blockade With Sugammadex or Usual Care in Hip Fracture Surgery or Joint (Hip/Knee) Replacement (P07038)
Status: COMPLETED
Conditions: Neuromuscular Blockade|Arthroplasty, Replacement, Hip|Arthroplasty, Replacement, Knee|Blood Coagulation|Antithrombotic Agents
Interventions: DRUG: Sugammadex|DRUG: neostigmine and glycopyrrolate or atropine|DRUG: Placebo to neostigmine|DRUG: Placebo to sugammadex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Twice Daily Enoxaparin Prophylaxis in Reconstructive Surgery Patients
Status: COMPLETED
Conditions: Venous Thromboembolism|Deep Venous Thrombosis|Pulmonary Embolus
Interventions: DRUG: Twice daily enoxaparin prophylaxis|DRUG: Real time dose adjustment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Stereotactic Body Radiation Therapy and Aflibercept in Treating Patients With Uveal Melanoma
Status: COMPLETED
Conditions: Uveal Melanoma
Interventions: RADIATION: Stereotactic Body Radiation Therapy|BIOLOGICAL: Ziv-Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vital Pulp Treatment in Primary Teeth
Status: ACTIVE_NOT_RECRUITING
Conditions: Vital Pulp Therapies|Indirect Pulp Cap|Pulpotomy
Interventions: DRUG: Mineral Trioxide Aggregate|DRUG: Biodentin|DEVICE: Vitrebond
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Standard Versus High Dose ED-Initiated Buprenorphine Induction
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder
Interventions: DRUG: Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone for iPACK Block With ACB in Total Knee Arthroplasty
Status: NOT_YET_RECRUITING
Conditions: Knee Osteoarthritis|Knee Pain Chronic|Knee Arthritis
Interventions: DRUG: Ropivacaine|DRUG: Ropivacaine+Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Budesonide MMX® vs. Budesonide CR for Induction of Remission in Microscopic Colitis
Status: NOT_YET_RECRUITING
Conditions: Microscopic Colitis
Interventions: DRUG: Budesonide MMX®|DRUG: Budesonide controlled ileal release (CR) capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eplerenone in Patients Undergoing REnal Transplant (EPURE TRANSPLANT)
Status: ACTIVE_NOT_RECRUITING
Conditions: End-stage Renal Disease
Interventions: DRUG: Eplerenone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proof-of-concept Study of Forward Pharma (FP)187 in Patients With Mild/Moderate Psoriatic Arthritis
Status: WITHDRAWN
Conditions: Psoriatic Arthritis
Interventions: DRUG: FP187|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of Mulligan Pain Release Phenomenon With and Without Tapping in Patellofemoral Pain Syndrome
Status: RECRUITING
Conditions: Patellofemoral Pain Syndrome
Interventions: OTHER: mulligan pain release phenomenon with tapping|OTHER: mulligan pain release phenomenon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Multimodal Physiotherapy Program With Virtual Reality Glasses in Duchenne and Becker.
Status: COMPLETED
Conditions: Muscular Dystrophy, Duchenne and Becker Types
Interventions: OTHER: multimodal physiotherapy program with RV|OTHER: traditional physiotherapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: German Translation and Cross-cultural Adaptation of the Headache Screening Questionnaire (HSQ) Followed by a Test-retest Reliability Study.
Status: RECRUITING
Conditions: Migraine|Tension-Type Headache
Interventions: DIAGNOSTIC_TEST: Headache Screening Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cystic Fibrosis Microbiome-determined Antibiotic Therapy Trial in Exacerbations: Results Stratified
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Ceftazidime|DRUG: Tobramycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Insomnia in the Patient With Schizophrenic Disorder: Evaluation of a CBT and Psychoeducational Intervention
Status: COMPLETED
Conditions: Insomnia|Schizophrenia
Interventions: BEHAVIORAL: cognitive behavioural intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT