pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Kinesio Tape in Muscle Fatigue Measured by Biering-Sorensen Test
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Kinesio Taping|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy
Status: RECRUITING
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: Upadacitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remote Ischemic Preconditioning on Pulmonary Injury in Cardic Surgery
Status: UNKNOWN
Conditions: Lung Injury|Remote Ischemic Preconditioning
Interventions: PROCEDURE: Remote Ischemic Preconditioning|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Ultra Low Doses of Therapy With Radiation Applicated to COVID-19
Status: SUSPENDED
Conditions: Pneumonia, Viral|Cytokine Storm
Interventions: RADIATION: Ultra-Low-dose radiotherapy|DEVICE: ventilatory support with oxygen therapy|DRUG: Lopinavir/ritonavir|DRUG: Hydroxychloroquine|DRUG: Azithromycin|DRUG: Piperacillin/tazobactam|DRUG: Low molecular weight heparin|DRUG: Corticosteroid injection|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prevalence of Latent Tuberculosis Infection in Health-care Workers and Students
Status: RECRUITING
Conditions: Tuberculosis|Tuberculosis, Pulmonary|Tuberculosis Infection|Latent Tuberculosis|Health Care Associated Infection
Interventions: DIAGNOSTIC_TEST: Prevalence of Latent Tuberculosis Infection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Efficacy and Safety With the Transdermal Contraceptive System Versus Mercilon.
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: norelgestromin + ethinyl estradiol; mercilon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia
Status: RECRUITING
Conditions: Sickle Cell Anemia|Beta Thalassemia
Interventions: RADIATION: TBI|DRUG: Hydroxyurea|BIOLOGICAL: briquilimab|DRUG: Filgrastim (G-CSF)|DRUG: Sirolimus|BIOLOGICAL: Alemtuzumab|DRUG: Plerixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Asha Improving Health and Nutrition of Indian Women With AIDS and Their Children
Status: COMPLETED
Conditions: HIV Infection
Interventions: BEHAVIORAL: Asha Support + Training|BEHAVIORAL: Asha Support + Food|BEHAVIORAL: Asha Support + Training + Food|BEHAVIORAL: Asha Support Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Programme Evaluation on Effectiveness of The Use of Movement-based x 'Elderspirituality - Fu Le Mun Sum' Intervention to Support Elderly People With Depressive Symptoms
Status: COMPLETED
Conditions: Depression in Old Age
Interventions: BEHAVIORAL: Dance Movement Therapy (DMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Different Dietary Interventions on Abdominal Fat Components and Cardiometabolic Parameters.
Status: ENROLLING_BY_INVITATION
Conditions: Abdominal Obesity|Cardiac Disease|Metabolic Disease|Cardiometabolic Syndrome
Interventions: BEHAVIORAL: Calorie restriction and balanced distribution of macronutrients|BEHAVIORAL: Calorie restriction and low-carbohydrate diet|BEHAVIORAL: Calorie restriction and low-fat diet|BEHAVIORAL: Collective nutritional guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Resting Energy Needs in Brain Dead Patients (reSting EneRgy nEeds iN brAin DEad Patients)
Status: COMPLETED
Conditions: Brain Death|Brain Injuries|Brain Edema|Brain Hemorrhage
Interventions: DIAGNOSTIC_TEST: REE - Resting Energy Expenditure|DIAGNOSTIC_TEST: Transcranial Doppler
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Self-Management to Prevent Ulcers in Veterans With SCI (Spinal Cord Injury)
Status: COMPLETED
Conditions: Pressure Ulcers|Spinal Cord Injuries
Interventions: BEHAVIORAL: Self Management (SM)|BEHAVIORAL: Motivational Interviewing (MI)|BEHAVIORAL: Education (ED)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Early Terlipressin Plus Albumin Therapy in Comparison to Standard Treatment for HRS-AKI in Acute-on-chronic Liver Failure.
Status: COMPLETED
Conditions: Acute-On-Chronic Liver Failure|Hepatorenal Syndrome|Acute Kidney Injury
Interventions: DRUG: Terlipressin|BIOLOGICAL: Albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Afuresertib +Sintilimab+Chemotherapy in Patients With Selected Solid Tumors That Resistance to Prior Anti-PD-1/PD-L1
Status: RECRUITING
Conditions: Solid Tumor|NSCLC|Cervical Cancer|Endometrial Cancer|Esophageal Cancer|Gastric and Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Afuresertib|DRUG: Nab paclitaxel|DRUG: Docetaxel|DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Assess the Potential Clinical Utility of 18F Fluciclovine PET for Cervical and Endometrial Cancer.
Status: TERMINATED
Conditions: Cervical Cancer|Uterine Cancer
Interventions: DRUG: 18F fluciclovine|DEVICE: 18F fluciclovine PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Secondary Prevention of Depression Applying an Experimental Attentional Bias Modification Procedure
Status: COMPLETED
Conditions: Major Depression
Interventions: BEHAVIORAL: Attention Bias Modification|BEHAVIORAL: Sham Attention Bias Modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Effects of Tasimelteon vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD)
Status: RECRUITING
Conditions: Sleep Wake Disorders|Sleep Disorders, Circadian Rhythm|Chronobiology Disorders
Interventions: DRUG: Tasimelteon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impedance Cardiography: Clinical Evaluation of Endotracheal Cardiac Output Monitor (ECOM)
Status: COMPLETED
Conditions: Cardiac Output
Interventions: DEVICE: Placed ECOM endotracheal cardiac output monitor in patients undergoing cardiac surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Empagliflozin + Linagliptin + Metformin + Lifestyle in Patients With Prediabetes
Status: UNKNOWN
Conditions: Prediabetic State|Insulin Resistance
Interventions: COMBINATION_PRODUCT: Linagliptin + metformin and Empagliflozin + metformin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CT Perfusion Images in Assessing Treatment Response in Patients With Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Ductal Adenocarcinoma
Interventions: DIAGNOSTIC_TEST: Computed Tomography Perfusion Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Mental Stress Ischemia: Biofeedback Study
Status: COMPLETED
Conditions: Cardiovascular Disease|Coronary Artery Disease
Interventions: BEHAVIORAL: Heart Rate Variability (HRV) Biofeedback (BF)|OTHER: Mental Stress Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Docetaxel With Doxercalciferol or Placebo for Advanced Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Docetaxel plus doxercalciferol|DRUG: Docetaxel plus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Anamorelin HCl in Patients With Non-Small Cell Lung Cancer-Cachexia (ROMANA 2)
Status: COMPLETED
Conditions: Cachexia|Non-Small Cell Lung Cancer
Interventions: DRUG: Anamorelin HCl|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repeated Nasal Challenge in Skin Prick-puncture Negative and Intradermal Positive Dust Mite Allergic Rhinitis Patients
Status: COMPLETED
Conditions: ALLERGIC RHINITIS
Interventions: BIOLOGICAL: dust mite extract or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Hyperglycemia and Cardiovascular Outcomes With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Acute Myocardial Infarction
Interventions: DRUG: Insulin lispro|DRUG: Human insulin isophane suspension (NPH)|DRUG: Insulin glargine|DRUG: Human insulin isophane suspension|DRUG: Human insulin 30/70
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Non-invasive Ventilation (NIV) on Cerebral Oxygenation
Status: COMPLETED
Conditions: Respiratory Insufficiency
Interventions: DEVICE: Somanetics INVOS Cerebral Oxymeter 5100C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Near-infrared Spectroscopy Guided Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction|Coronary Artery Disease|Myocardial Ischemia|Atherosclerosis|Lipid-Rich Atherosclerosis of Coronary Artery|Vascular Diseases|Infarct Ischemia
Interventions: DEVICE: Near-infrared spectroscopy (NIRS)|DEVICE: Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peripheral Nerve Stimulation of Genicular Nerves Versus Conventional Therapy With Intra-articular Steroid Injection for Chronic Knee Pain: A Prospective, Randomized Pilot Study
Status: RECRUITING
Conditions: Peripheral Nerve Stimulation|Genicular Nerves|Chronic Knee Pain
Interventions: OTHER: PNS therapy|DRUG: Triamcinolone|DRUG: Bupivacaine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical or Non-surgical Treatment of Plantar Fasciitis
Status: RECRUITING
Conditions: Fasciitis, Plantar, Chronic
Interventions: PROCEDURE: Radiofrequency microtenotomy|BEHAVIORAL: Strength training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ceftazidime Pharmacokinetic in Cerebrospinal Fluid Between Continuous and Intermittent Administration
Status: UNKNOWN
Conditions: Pseudomonas Aeruginosa Meningitis
Interventions: DRUG: ceftazidime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Decreasing the Inspired Oxygen Concentration on Post-Operative Oxygenation After Primary Lobectomy
Status: WITHDRAWN
Conditions: Hyperoxia
Interventions: DRUG: 60% oxygen|DRUG: 100% oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Exercise Effects on Cardiovascular Risk Factors, Quality of Life, Muscle Function in Type 2 Diabetes and Healthy Persons
Status: UNKNOWN
Conditions: Type 2 Diabetes|Impaired Glucose Tolerance
Interventions: BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessment of the Relationship Between Affective Temperament and the Severity of Nausea and Vomiting in Early Pregnancy
Status: COMPLETED
Conditions: Hyperemesis Gravidarum|Temperament|Morning Sickness
Interventions: OTHER: TEMPS-A (Temperament Evaluation of Memphis, Pisa, Paris and San Diego Auto-questionnaire)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: CD123 Redirected Autologous T Cells for AML
Status: TERMINATED
Conditions: Relapsed or Refractory Acute Myeloid Leukemia
Interventions: BIOLOGICAL: Autologous Anti-CD 123 CAR TCR/4-1BB-expressing T-lymphocytes|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of INS068 in Patients With Type 2 Diabetes Not Adequately Controlled With One or Two Oral Antidiabetics
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: INS068 injection|DRUG: Insulin Degludec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectivness of Topical Tacrolimus Monotherapy in Patients With Vitiligo
Status: UNKNOWN
Conditions: Vitiligo|Tacrolimus
Interventions: DRUG: Tacrolimus 0.03% Ointment|DRUG: Hydrocortisone Acetate 1% Ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Look at Day to Day Changes in Lung Function in COPD Subjects Taking Albuterol/Salbutamol and Ipratropium
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Albuterol/salbutamol|DRUG: Ipratropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Bolus Speed of Rapid-Acting Insulin Analog Absorption and Action in Individuals With Type 1 Diabetes
Status: COMPLETED
Conditions: Type1diabetes
Interventions: DEVICE: Quick Bolus|DEVICE: Standard Bolus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Correlation Between New O3 Regional Oximetry, Electroencephalography and the Somatosensory Evoked Potential in Carotid Endarterectomy Surgery
Status: RECRUITING
Conditions: Carotid Endarterectomy
Interventions: DEVICE: Masimo's O3 Regional Oximetry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of BIIB067 (Tofersen) Initiated in Clinically Presymptomatic Adults With a Confirmed Superoxide Dismutase 1 Mutation
Status: RECRUITING
Conditions: Amyotrophic Lateral Sclerosis Associated With a SOD1 Gene Mutation
Interventions: DRUG: Tofersen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilates Training and Low Intensity Shock Wave Therapy for Post-prostatectomy Stress Incontinence
Status: ENROLLING_BY_INVITATION
Conditions: Stress Incontinence, Male
Interventions: DEVICE: The DUOLITH SD1-TOP focused shock wave system (STORZ MEDICAL AG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Preclinical Hypertrophic Cardiomyopathy With Diltiazem
Status: COMPLETED
Conditions: Hypertrophic Cardiomyopathy
Interventions: DRUG: Diltiazem|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Safety and Efficacy Study of Zilucoplan (RA101495) to Treat PNH Patients
Status: COMPLETED
Conditions: Paroxysmal Nocturnal Hemoglobinuria (PNH)
Interventions: DRUG: Zilucoplan (RA101495)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Intravaginal, Self-administered Artesunate Vaginal Pessaries Among Women in Kenya
Status: NOT_YET_RECRUITING
Conditions: Cervix Cancer|Cervix Intraepithelial Neoplasia Grade 3|Cervix; Intraepithelial Neoplasia, Grade I|Cervix; Intraepithelial Neoplasia, Grade II
Interventions: DRUG: Artesunate pessary|DIAGNOSTIC_TEST: blood draws for pharmacokinetics of the study drug
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Mental Health and School Performance in Urban Eighth Graders
Status: COMPLETED
Conditions: Depressive Symptoms|Trauma, Psychological|Disruptive Behavior
Interventions: BEHAVIORAL: RAP Club|BEHAVIORAL: Healthy Topics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Local Infiltration Analgesia or Intrathecal Morphine in Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Osteoarthritis
Interventions: DRUG: ropivacaine, ketorolac and epinephrine|DRUG: morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Dose Escalation Trial of Oral BIBF 1120 in Combination With Intravenous Carboplatin and Vinorelbine in Elderly Patients With Advanced Non-Small Cell Lung Cancer - Stage IV (VENUS-2)
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: BIBF 1120|DRUG: Vinorelbine|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tamoxifen, Ovarian Ablation, and/or Chemotherapy in Treating Women With Stage I, Stage II, or Stage IIIA Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: CMF regimen|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: fluorouracil|DRUG: goserelin acetate|DRUG: leuprolide acetate|DRUG: methotrexate|DRUG: tamoxifen citrate|PROCEDURE: oophorectomy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Multi-national Cirrhosis Study to Characterise the Association Between the Pharmacokinetics of NRL972 and Disease Severity.
Status: COMPLETED
Conditions: Hepatic Cirrhosis
Interventions: DRUG: NRL972
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation and Treatment of Pulmonary Vascular Disease in Moderate to Severe CF
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: sildenafil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Hormone Therapy as First-Line Therapy in Treating Postmenopausal Women With Metastatic or Locally Advanced Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: chemotherapy|DRUG: letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atherectomy Followed by a Drug Coated Balloon to Treat Peripheral Arterial Disease
Status: COMPLETED
Conditions: Peripheral Arterial Disease|Claudication
Interventions: DEVICE: Cotavance Drug-Eluting Balloon|DEVICE: TurboHawk/SilverHawk + Cotavance Drug-Eluting Balloon|DEVICE: TurboHawk/SilverHawk + Cotavance Drug-Eluting Balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Open Label First Line Therapy Study of MEDI 4736 (Durvalumab) With or Without Tremelimumab Versus SOC in Non Small-Cell Lung Cancer (NSCLC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small-Cell Lung Carcinoma NSCLC
Interventions: BIOLOGICAL: MEDI4736 (Durvalumab)|BIOLOGICAL: MEDI4736 (Durvalumab)+Tremelimumab|DRUG: Paclitaxel + Carboplatin|DRUG: Gemcitabine + Cisplatin|DRUG: Gemcitabine + Carboplatin|DRUG: Pemetrexed + Cisplatin|DRUG: Pemetrexed + Carboplatin|BIOLOGICAL: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MK-8033 in Patients With Advanced Solid Tumors (MK-8033-001)
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: DRUG: Comparator: MK-8033|DRUG: Comparator: MK-8033 +/- omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Pharmacology of GDC-0941 in Combination With Erlotinib in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Non-Squamous Non-Small Cell Lung Cancer, Solid Cancers
Interventions: DRUG: GDC-0941|DRUG: erlotinib HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Effectiveness Assessments of Restylane-Defyne for Punctual Occlusion
Status: COMPLETED
Conditions: Dry Eye
Interventions: DEVICE: Restylane Defyne
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: The Effect of Reducing Soreness in Marathon Runners
Status: COMPLETED
Conditions: Contracture of Muscle, Thigh
Interventions: DEVICE: Pulsed electromagnetic field devices|DEVICE: Pulsed electromagnetic field devices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Tolerability Study of Topical PAT-001 in Congenital Ichthyosis
Status: COMPLETED
Conditions: Congenital Ichthyosis
Interventions: DRUG: PAT-001, 0.1%|DRUG: PAT-001, 0.2%|DRUG: Vehicle for PAT-001 0.1%|DRUG: Vehicle for PAT-001 0.2%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Sunitinib Administered as 4/2 vs. 2/1 Schedule in Advanced Renal Cell Carcinoma (RCC)
Status: COMPLETED
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: Sunitinib 2/1|DRUG: Sunitinib 4/2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparisons Between Low Thoracic and Lumbar Epidural Analgesia on Postoperative Pain Low Thoracic v.s. Lumbar Epidural for Post-cesarean Pain
Status: COMPLETED
Conditions: Post-cesarean Pain Control Quality
Interventions: PROCEDURE: low thoracic epidural|PROCEDURE: lumbar epidural
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Controlled Trial of Angiotensin Receptor Blocker (ARB) & Chemokine Receptor Type 2 (CCR2) Antagonist for the Treatment of COVID-19
Status: TERMINATED
Conditions: COVID-19|SARS-CoV2 Infection
Interventions: DRUG: Candesartan Cilexetil|DRUG: Repagermanium|DRUG: Candesartan Placebo|DRUG: Repagermanium Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Insomnia and Glucose Metabolism
Status: COMPLETED
Conditions: Sleep|Insomnia|Insulin Resistance
Interventions: DRUG: Eszopiclone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to See How Safe and Tolerable Different Doses of REGN13335 Are When Administered Intravenously (IV) or Subcutaneously (SC) to Healthy Adult Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: REGN13335|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Two Different Treatment Approaches for Adolescents With Osgood Schlatter
Status: ACTIVE_NOT_RECRUITING
Conditions: Osgood-Schlatter Disease|Apophysitis|Osteochondrosis; Tibia|Physeal Injury
Interventions: OTHER: A novel treatment approach|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Irvingia Gabonensis (Bush Mango)and Cissus Quadrangularis to Reduce Weight and Blood Lipids
Status: COMPLETED
Conditions: Obesity|Overweight|Dyslipidemia
Interventions: DIETARY_SUPPLEMENT: Irvingia/cissus combo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Pilot Study To Define The Marker As An Alternate For Tropism Assay
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: maraviroc|PROCEDURE: Trofile Assay and HIV RNA quantification assay
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: The Analysis of Association of Retinopathy of Prematurity, Gut Microbiome Profile, and Systemic Inflammation
Status: ENROLLING_BY_INVITATION
Conditions: Retinopathy of Prematurity|Microbiome
Interventions: PROCEDURE: intravitreal injection of anti VEGF|PROCEDURE: laser photocoagulation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of AbobotulinumtoxinA for the Treatment of Platysmal Bands
Status: COMPLETED
Conditions: Platysmal Bands
Interventions: BIOLOGICAL: AbobotulinumtoxinA dose 1|OTHER: Placebo|BIOLOGICAL: AbobotulinumtoxinA dose 2|BIOLOGICAL: AbobotulinumtoxinA dose 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Development and Testing of a Sub-district Specific Model of 'Whole-of-government', and 'Whole-of-society' Approaches for the Prevention and Control of Non-communicable Diseases in a Sub-district of Bangladesh
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension|Diabetes|Asthma|Chronic Obstructive Pulmonary Disease (COPD)
Interventions: BEHAVIORAL: Behavioural change modification, Screening, NCD related knowledge practice and attitude
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Accuracy of Dental Contacts of an Occlusal Splint Made According to Conventional or Digital Techniques Using GeoMagic®.
Status: COMPLETED
Conditions: Occlusal Splints
Interventions: OTHER: Occlusal Splints Analogic-Analogic|OTHER: Occlusal Splints Analogic-Digital|OTHER: Occlusal Splints Digital-Digital
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Influence of Coffee Intake on Postoperative Bowel Function After Comprehensive Staging Surgery for Gynecological Malignancies: A Randomized Controlled Trial.
Status: COMPLETED
Conditions: Ilues
Interventions: DIETARY_SUPPLEMENT: caffe|DIETARY_SUPPLEMENT: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Triplet Combination With Pembrolizumab, Neratinib, and Paclitaxel as a Second Line Treatment in Recurrent/Advanced Gastric Cancer Having Somatic Human Epidermal Growth Factor Receptor Family (EGFR, HER2, HER3, HER4) Mutations or HER2 Amplification/Overexpression
Status: WITHDRAWN
Conditions: Recurrent/Advanced Gastric Cancer
Interventions: DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paricalcitol in Treating Patients With Advanced Prostate Cancer and Bone Metastases
Status: TERMINATED
Conditions: Metastatic Cancer|Prostate Cancer
Interventions: DRUG: paricalcitol|OTHER: immunoenzyme technique|OTHER: laboratory biomarker analysis|PROCEDURE: dual x-ray absorptometry|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Safety and the Efficacy Evaluation of Allogenic Adipose MSC-Exos in Patients With Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: BIOLOGICAL: low dosage MSCs-Exos administrated for nasal drip|BIOLOGICAL: mild dosage MSCs-Exos administrated for nasal drip|BIOLOGICAL: high dosage MSCs-Exos administrated for nasal drip
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurochemical, Metabonomics and Neuroimaging Characterization of TCM Diagnostic Subtypes of Major Depression Disorder
Status: UNKNOWN
Conditions: Severe Major Depression Disorder
Interventions: DRUG: venlafaxine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pain Management After Surgery
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: OxyCODONE 5 mg Oral Tablet|DRUG: Acetaminophen 500Mg Tab|DRUG: Naproxen 500 Mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mepivacaine vs. Bupivacaine Spinal for TKA
Status: RECRUITING
Conditions: Total Knee Replacement
Interventions: OTHER: Mepivacaine Spinal|OTHER: Bupivacaine Spinal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: A Phase I/IIa Study of GC3110A (Quadrivalent Influenza Vaccine)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Quadrivalent influenza vaccine|BIOLOGICAL: Trivalent influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Influence of Eccentric Training on the Volume and Vascularisation of the Rotator Cuff in Patients With Rotator Cuff Tendinopathy and Healthy Subjects
Status: COMPLETED
Conditions: Rotator Cuff Tendinopathy
Interventions: BEHAVIORAL: Eccentric exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PAZOPANIB Efficacy and Tolerance in Desmoids Tumors
Status: COMPLETED
Conditions: Progressive Desmoids Tumors
Interventions: DRUG: PAZOPANIB treatment|DRUG: Active Comparator: Vinblastine and Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ZN-c3 in Combination With Gemcitabine in Subjects With Osteosarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteosarcoma
Interventions: DRUG: ZN-c3|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRI Investigations in Attention Deficit Hyperactivity Disorder (ADHD) and High Potential (HP) Children for a Better Therapeutic Approach
Status: COMPLETED
Conditions: ADHD
Interventions: OTHER: MRI|OTHER: neuropsychological assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Following Patients After Selective and Pascal Laser Trabeculoplasty for Treatment of Chronic Open-Angle Glaucoma
Status: UNKNOWN
Conditions: Glaucoma, Open-Angle|Glaucoma, Primary Open Angle|Exfoliation Glaucoma|Glaucoma, Pigmentary
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Oral Plaque Removal Utilizing an Adjunct Enzyme Pre-rinse
Status: COMPLETED
Conditions: Dental Plaque|Dental Caries
Interventions: DRUG: Bromelain|OTHER: Powdered sugar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clofarabine Followed By Lenalidomide for High-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Myeldysplastic Syndrome (MDS)|Chronic Myelomonocytic Leukemia|Bone Marrow Diseases|Neutropenia|Acute Myeloid Leukemia (AML)
Interventions: DRUG: Clofarabine|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Dose Pharmacokinetic (PK) and Safety Study of GSK2838232 With and Without Ritonavir (RTV) Conducted in Healthy Subjects
Status: TERMINATED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: GSK2838232 PIB (SDD)|DRUG: GSK2838232 PIB (API)|DRUG: Placebo|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DE-111 Ophthalmic Solution in Patients With Open Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open Angle Glaucoma or Ocular Hypertension
Interventions: DRUG: DE-111 ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STunning in Acute Myocardial Infarction - BAS
Status: NOT_YET_RECRUITING
Conditions: Myocardial Infarct
Interventions: DRUG: Bisoprolol Oral Tablet|DRUG: Ramipril Oral Product|DRUG: Dapagliflozin Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of rAAV.hCNGA3 Gene Therapy in Patients With CNGA3-linked Achromatopsia
Status: ACTIVE_NOT_RECRUITING
Conditions: Achromatopsia
Interventions: DRUG: rAAV.hCNGA3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapy for Patients With Untreated Age-Adjusted International Prognostic Index Low-Intermediate Risk, High-Intermediate Risk, or High Risk Diffuse Large B Cell Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Etoposide, carboplatin, ifosfamide|DRUG: Rituximab, Ifosfamide, Etoposide, Carboplatin|DRUG: Rituximab, Ifosfamide, Etoposide, Carboplatin, Stem Cell Collection, Mitoxantrone, Cyclophosphamide and etoposide, Carmustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immersive Virtual Reality and Physical Exercise on Cognitive and Functional Performance in Hospitalized Older Patients
Status: NOT_YET_RECRUITING
Conditions: Disability Physical|Cognition
Interventions: DEVICE: Virtual reality|BEHAVIORAL: multicomponent exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Radiation Therapy, Combination Chemotherapy, and Amifostine in Treating Patients With Head and Neck Cancer
Status: COMPLETED
Conditions: Carcinoma of Unknown Primary|Head and Neck Cancer
Interventions: DRUG: amifostine trihydrate|DRUG: cisplatin|DRUG: fluorouracil|DRUG: paclitaxel|PROCEDURE: quality-of-life assessment|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Treatment Effects of Bisoprolol and Verapamil in Symptomatic Patients With Non-obstructive Hypertrophic Cardiomyopathy
Status: RECRUITING
Conditions: Non-obstructive Hypertrophic Cardiomyopathy
Interventions: DRUG: Verapamil|DRUG: Bisoprolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of IV Topotecan/Docetaxel to Docetaxel Alone in Second-Line Stage IIIB/IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer, Non-Small Cell|Non-Small-Cell Lung Cancer
Interventions: DRUG: Topotecan/Docetaxel combination|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Therapy With PS 341 in Patients With Advanced Stage Non Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: PS-341 (Velcade-drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mother Scented Simulated Hand for Mechanically Ventilated Preterm Neonates During Invasive Procedures?
Status: COMPLETED
Conditions: Pain|Distress, Emotional
Interventions: BEHAVIORAL: Mother-Scented Simulated Hand|BEHAVIORAL: NICU Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Epsilon Aminocaproic Acid (EACA) for the Reduction of Blood Loss in Total Hip Arthroplasty (THA)
Status: COMPLETED
Conditions: Degenerative Joint Disease|Osteoarthritis
Interventions: OTHER: EACA|OTHER: Placebo arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Trebananib With or Without Bevacizumab, Pazopanib Hydrochloride, Sorafenib Tosylate, or Sunitinib Malate in Treating Patients With Advanced Kidney Cancer
Status: COMPLETED
Conditions: Advanced Renal Cell Carcinoma|Advanced Sarcomatoid Renal Cell Carcinoma|Stage III Renal Cell Cancer AJCC v7|Stage IV Renal Cell Cancer AJCC v7
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Pazopanib Hydrochloride|DRUG: Sorafenib Tosylate|DRUG: Sunitinib Malate|BIOLOGICAL: Trebananib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paleolithic Diets vs T2D and Improvements in the Metabolic Syndrome
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: Paleolithic diet|OTHER: ADA ( American Diabetes Association) recommended diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Feasibility and Efficacy of Modified Donor Lymphocytes Infusion (CD45RA Negative Selected) After Haploidentical Transplantation With Post-transplantation Cyclophosphamide in Patients With Hematological Malignancies (ONC-2016-002).
Status: COMPLETED
Conditions: Bone Marrow Transplant Infection|Bone Marrow Transplant Complications|Graft Vs Host Disease|Infection|Hematological Malignancy
Interventions: BIOLOGICAL: modified donor lymphocytes infusion (mDLI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Ultrasound Guided Hyaluronic Injection in Treatment of Trigger Finger
Status: UNKNOWN
Conditions: Trigger Digit
Interventions: DRUG: Hyaluronic Acid|DRUG: Triamcinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Psycho-esthetic Impact of Tattoo Technology as Part of Mammary Reconstruction After Surgery Against Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Right or Left Breast Mammary Reconstruction|Malignant Neoplasm Reconstruction by Tattoo of Areola of Female Breast
Interventions: PROCEDURE: Tattoo
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Combining Prophylactic Curosurf With Early Nasal CPAP in Delivery Room: the Curpap Study
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Newborn
Interventions: DRUG: Poractant alfa (Curosurf®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Applying Multidisciplinary Bundle Intervention on the Delirium Incidence in Critically Ill Patients
Status: UNKNOWN
Conditions: Delirium
Interventions: OTHER: Ear plug|OTHER: Eye mask|OTHER: Mixed intervention (ear plug and eye mask)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluate the Effect of Synbiotics on MAFLD
Status: RECRUITING
Conditions: Metabolic Dysfunction-Associated Fatty Liver Disease
Interventions: DIETARY_SUPPLEMENT: G-NiiB synbiotics formula (SLP07)|DIETARY_SUPPLEMENT: Active placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Safety of Nebulized Combination Therapy BromAc® in COVID-19 Respiratory Disease
Status: UNKNOWN
Conditions: COVID-19 Pneumonia|COVID-19|Ventilator Associated Pneumonia|COVID-19 Acute Respiratory Distress Syndrome
Interventions: DRUG: Bromelains|DRUG: Acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thetha Nami Ngithethe Nawe ("Let's Talk"): Step Wedge cRCT of Peer Led Community PrEP and SRH for Youth in South Africa
Status: RECRUITING
Conditions: HIV-1-infection|Sexually Transmitted Diseases
Interventions: COMBINATION_PRODUCT: Community-based differentiated HIV prevention incl.PrEP with SRH|OTHER: Primary Health Clinic based HIV prevention and care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of MEHD7945A + FOLFIRI Versus Cetuximab + FOLFIRI as Second Line Therapy in Participants With KRAS Wild-Type Metastatic Colorectal Cancer (mCRC)
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: 5-fluorouracil|DRUG: Cetuximab|DRUG: Irinotecan|DRUG: Leucovorin|DRUG: MEHD7945A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of AST-120 for Evaluating Prevention of Progression In Chronic Kidney Disease (EPPIC-1)
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Placebo|DRUG: AST-120
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Contribution of Functional MRI in Assessment of Auditory Processing Disorders
Status: UNKNOWN
Conditions: Auditory Processing Disorders
Interventions: DIAGNOSTIC_TEST: functional MRI|DIAGNOSTIC_TEST: Automated Cortical Brainstem Auditory Evoked Potential|GENETIC: whole exome sequencing|DIAGNOSTIC_TEST: Standard Cortical Brainstem Auditory Evoked Potential|DIAGNOSTIC_TEST: multidisciplinary consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Chronic Subdural Hematoma Treatment With Intra-Arterial Bevacizumab Injection
Status: RECRUITING
Conditions: Chronic Subdural Hematoma
Interventions: DRUG: Bevacizumab 2 mg/kg|DRUG: Bevacizumab 4 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wheat Germ Supplementation Will Improve Markers of Gut Health, Inflammation, and Insulin Resistance in Overweight Adults
Status: COMPLETED
Conditions: Overweight|Insulin Resistance|Inflammation
Interventions: OTHER: Wheat germ energy ball|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Oxygen Treatment and Pulmonary Arterial Hypertension
Status: UNKNOWN
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Oxygen supplementation|DRUG: Sham O2 (medical air)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT