pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Evaluate the Safety and Effectiveness of a Silicone Hydrogel Custom Contact Lens When Compared to Alden Optical HP Sphere Lens
Status: COMPLETED
Conditions: Contact Lens Wear
Interventions: DEVICE: Custom Samfilcon B Contact Lenses|DEVICE: Alden Optical HP Sphere Contact Lens|DEVICE: ReNu MultiPlus Lubricating and Rewetting Drops|DEVICE: Biotrue Multi-Purpose Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Multicenter, Randomized, Controlled Study to Assess Mitral vAlve reconsTrucTion for advancEd Insufficiency of Functional or iscHemic ORigiN
Status: UNKNOWN
Conditions: Mitral Valve Insufficiency
Interventions: DEVICE: MitraClip system (Abbott Vascular, Menlo Park, USA)|PROCEDURE: Mitral valve surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endovascular Repair of Thoracoabdominal Aortic Aneurysms
Status: ACTIVE_NOT_RECRUITING
Conditions: Thoracoabdominal Aortic Aneurysm
Interventions: DEVICE: Valiant Thoracoabdominal Stent Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of the Menin Inhibitor Revumenib in Leukemia Associated With Upregulation of HOX Genes
Status: RECRUITING
Conditions: Leukemia|HOX Gene
Interventions: DRUG: Revumenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PAracetamol Treatment in Hypertension: Effect on Blood Pressure (PATH-BP) Study
Status: COMPLETED
Conditions: Blood Pressure
Interventions: DRUG: Paracetamol|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Optimizing Cardiac Rehabilitation by Integrating Sleep Therapeutics
Status: WITHDRAWN
Conditions: Sleep Wake Disorders|Sleep Disturbance|Sleep-Related Impairment
Interventions: BEHAVIORAL: Transdiagnostic Sleep and Circadian Intervention (TranS-C), adapted for cardiac rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: n-3 Fatty Acid Effects in T2DM After Acute High Intensity Exercise
Status: COMPLETED
Conditions: Type2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: n-3 PUFA Group|DIETARY_SUPPLEMENT: Placebo Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fruquintinib as First Line Treatment in Patients With Recurrent Esophageal Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Fruquintinib Combined With Camrelizumab, Paclitaxel Liposome and Nedaplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Technology-Assisted Yoga and Exercise on Neuropathy and Pain in Children With Leukemia
Status: COMPLETED
Conditions: Leukemia|Children With Cancer|Yoga Therapy|Excercise|Neuropathy;Peripheral|Pain
Interventions: BEHAVIORAL: yoga and exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Pharmacokinetics & Food Effect of MK-0941 in Adults With Type 2 Diabetes (MK-0941-009)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: 10 mg MK-0941 DFC (fasted)|DRUG: 10 mg MK-0941 OCT (after meal)|DRUG: 10 mg MK-0941 OCT (before meal)|DRUG: 10 mg MK-0941 OCT (fasted)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Cardiac Implantable Electronic Devices on the Hemostatic System
Status: COMPLETED
Conditions: Thromboembolism|Cardiac Event|Hemostatic Disorder
Interventions: PROCEDURE: Cardiac implantable electronic device implantation.|PROCEDURE: Cardiac implantable electronic device replace.|DIAGNOSTIC_TEST: Duplex ultrasound.|DIAGNOSTIC_TEST: Echocardiography.|DIAGNOSTIC_TEST: Blood sampling.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.
Status: RECRUITING
Conditions: Breast Cancer|Metastatic Breast Cancer|Breast Neoplasm|Breast Cancer Metastatic|End Stage Cancer
Interventions: BIOLOGICAL: SV-BR-1-GM|DRUG: Cyclophosphamide|DRUG: Interferon infiltration of the inoculation site|DRUG: Retifanlimab|DRUG: Treatment of Physician's Choice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of Lintuzumab Combined With Lenalidomide in Patients With Myelodysplastic Syndromes (MDS)
Status: COMPLETED
Conditions: Myelodysplastic Syndrome (MDS)
Interventions: DRUG: lintuzumab|DRUG: lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quality of Life Related to Different Treatment Protocols for Post-thyroidectomy Hypoparathyroidism
Status: RECRUITING
Conditions: Hypoparathyroidism Postprocedural|Quality of Life
Interventions: OTHER: Empiric use of Calcium Carbonate and Calcitriol|OTHER: PTH based Calcium Carbonate and Calcitriol repletion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Casein Glycomacropeptide in Active Distal Ulcerative Colitis (Pilot Study)
Status: COMPLETED
Conditions: Colitis, Ulcerative|Inflammatory Bowel Diseases
Interventions: DRUG: CGMP protein|DRUG: Maximal oral 5ASA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anemia Study in Chronic Kidney Disease (CKD) : Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat -Forearm Blood Flow (ASCEND-FBF)
Status: TERMINATED
Conditions: Anaemia
Interventions: DRUG: Daprodustat|DRUG: Darbepoetin alfa|DRUG: Acetylcholine|DRUG: Sodium nitroprusside|DRUG: L-N-monomethyl arginine acetate (L-NMMA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of PK of Caprylic Triglyceride Oil, AC-1202, AC-1204, and Axona on Ketone Body Production
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Caprylic Triglyceride Oil|DRUG: AC-1202|DRUG: Axona|DRUG: AC-1204
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Optimal PeriproCeduraL AnticOagulation in Structural Transseptal Interventions
Status: ENROLLING_BY_INVITATION
Conditions: Mitral Regurgitation|Atrial Fibrillation|Anticoagulation
Interventions: OTHER: early anticoagulation|OTHER: late anticoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Hypothermia and Thrombectomy in Acute Stroke
Status: NOT_YET_RECRUITING
Conditions: Ischemic Stroke|Large Vessel Occlusion|Endovascular Treatment
Interventions: DEVICE: hypothermia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Concurrent Chemoradiotherapy Using Intensity Modulated Radiotherapy (IMRT) & Docetaxel-cisplatin (or Carboplatin) Followed by Adjuvant Chemotherapy for Inoperable Stage III Non-small-cell Lung Cancer
Status: COMPLETED
Conditions: Lung Neoplasms
Interventions: DRUG: DOCETAXEL|RADIATION: Intensity Modulated Radiotherapy (IMRT)|DRUG: CISPLATIN
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Probiotics in HIV Patients With Immunological Non-Responder
Status: COMPLETED
Conditions: HIV Infections|Immunological Abnormality
Interventions: DRUG: Rillus®|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GWMD1092 - GWP42003 : GWP42004 Together Plus Alone in Type II Diabetes
Status: COMPLETED
Conditions: Dyslipidemias|Diabetes Mellitus, Type 2
Interventions: DRUG: GWP42003|DRUG: GWP42003|DRUG: GWP42004|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia
Interventions: OTHER: Reduced intensification|DRUG: Standard childhood UK ALL protocol|DRUG: Intensified treatment including Capizzi maintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Using Closed-suction Drainage in Treating Proximal Femur Fracture With Cephalomedullary Nail
Status: COMPLETED
Conditions: Intertrochanteric Fractures
Interventions: DEVICE: hemovac drain (Zimmer Biomet, Autotransfusion System [HAS], United State)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Soy-milk and Cow Milk Consumption on Inflammatory Factors, Cardiovascular Factors ,Renal Factors, Fibrinolytic Indice and Oxidative Stress Among Type-2 Diabetic Patients With Nephropathy Stage 1 and 2
Status: COMPLETED
Conditions: Inflammation|Oxidative Stress|Fibrinolytic Markers|Blood Pressure and Cardiorenal Risk Factors
Interventions: DIETARY_SUPPLEMENT: soy milk|DIETARY_SUPPLEMENT: cow's milk
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: |Primary Purpose:
Clinical trial: A Multi-center, Open-label, Randomized, Parallel Group Study to Evaluate Pharmacokinetic Profile, Effects on the Mechanisms of Contraceptive Efficacy and Safety of Two Progestin-only Patches Containing Different Doses of Levonorgestrel (LNG)
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: levonorgestrel patch with BMI 32 kg/m2 to <40 kg/m2|DRUG: levonorgestrel patch with BMI <32 kg/m2|DRUG: levonorgestrel patch with BMI 32 kg/m2 to <40 kg/m2|DRUG: levonorgestrel patch with BMI <32 kg/m2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Start Taking Action For TB Diagnosis
Status: NOT_YET_RECRUITING
Conditions: Diagnosis|Tuberculosis
Interventions: DIAGNOSTIC_TEST: Molecular Diagnostics|DIAGNOSTIC_TEST: Qualitative C-Reactive Protein (CRP)|DIAGNOSTIC_TEST: Point of Care (POC) C-Reactive Protein (CRP): Quantitative CRP|DIAGNOSTIC_TEST: Urine lateral flow tests|DIAGNOSTIC_TEST: Portable Chest X Ray Image Acquisition
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: OBS in Adolescent and Adults With EOE: A Phase II, Randomized, Double-Blind, Placebo Controlled, Study With an Open Label Extension
Status: COMPLETED
Conditions: Eosinophilic Esophagitis (EoE)
Interventions: DRUG: Oral Budesonide Suspension (MB-9)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cold Therapy in the Treatment of Exercise-induced Muscle Damage
Status: COMPLETED
Conditions: Cryotherapy Effect
Interventions: OTHER: single exposure at 5°C in CWI|OTHER: single exposure at 15°C in CWI|OTHER: multiple exposures at 10°C in CWI|OTHER: whole body cryotherapy (WBC)|OTHER: passive recovery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Toothbrush in the Genesis and Prevention of Dental Recessions
Status: NOT_YET_RECRUITING
Conditions: Recession, Gingival
Interventions: DEVICE: soft bristle toothbrush|DEVICE: mechanical toothbrush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: rhTPO Mobilized Auto Cryo Platelets For GYN Patients Receiving Carboplatin
Status: COMPLETED
Conditions: Neoplasms, Gynecologic
Interventions: DRUG: Thrombopoietin|PROCEDURE: Platelet-pheresis|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence and Food Effect Bioavailability Study of Lumacaftor Film-Coated Tablets
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Lumacaftor 200 mg/Ivacaftor 125 mg Film-Coated Tablet|DRUG: Lumacaftor 200 mg Film-Coated Tablet Formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Efficacy Between Silicone Ahmed Glaucoma Valves With and Without Intravitreal Triamcinolone Injection
Status: UNKNOWN
Conditions: Neovascular Glaucoma
Interventions: PROCEDURE: Glaucoma drainage implant with/without triamcinolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal)
Status: COMPLETED
Conditions: Adverse Reaction to Spinal Anesthetic|Maternal Care for Cervical Incompetence
Interventions: DRUG: Chloroprocaine|DRUG: Bupivacaine|DRUG: Fentanyl|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Efficacy and Safety of ABT-450/Ritonavir/ABT- 267 (ABT-450/r/ABT-267) in Japanese Adults With Genotype 2 Chronic Hepatitis C Virus (HCV) Infection
Status: COMPLETED
Conditions: Hepatitis C Virus
Interventions: DRUG: ABT-450/r/ABT-267|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of YM150 on the Plasma Concentration of Digoxin in Healthy Subjects
Status: COMPLETED
Conditions: Healthy|Pharmacokinetic of Digoxin
Interventions: DRUG: YM150|DRUG: placebo|DRUG: digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Effects of Xanthohumol on Resting Energy Expenditure and Substrate Oxidation in Healthy Women
Status: COMPLETED
Conditions: Resting Energy Expenditure
Interventions: DIETARY_SUPPLEMENT: micellar solubilized Xanthohumol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Percutaneous Needle Electrolysis (PNE) in Soleus Injury
Status: COMPLETED
Conditions: Soleus Injury
Interventions: OTHER: Eccentric exercise|OTHER: PNE|OTHER: Combined
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antibiotic Therapy in Viral Airway Infections
Status: RECRUITING
Conditions: Infectious Disease|Influenza|Respiratory Syncytial Virus (RSV)|Respiratory Tract Infections
Interventions: OTHER: Stop antibiotic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Prasugrel and Clopidogrel in Very Elderly and Non-Elderly Patients With Stable Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: prasugrel|DRUG: clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Calprotectin, a Biomarker of COVID-19 Severity (CALPRO)
Status: NOT_YET_RECRUITING
Conditions: Severe/Moderate Coronavirus|Chronic Myelomonocytic Leukemia|Myelodysplastic Syndromes|Old Age
Interventions: BIOLOGICAL: Blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Triceps Taping on Elbow Flexion Tightness in Extended Erb's Palsy
Status: UNKNOWN
Conditions: Deformity Flexion
Interventions: OTHER: Kinesio Tape|OTHER: Physical therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Longitudinal Multimodal Response Assessment During Neoadjuvant Treatment of Rectal Cancer
Status: RECRUITING
Conditions: Locally Advanced Rectal Carcinoma|Neoadjuvant Treatment|Radiotherapy|Adaptive Treatment
Interventions: DIAGNOSTIC_TEST: Blood sample|DEVICE: MRI scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Evaluating Efficacy and Safety of Amiselimod (MT-1303) in Mild to Moderate Ulcerative Colitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: Low Dose MT-1303|DRUG: High Dose MT-1303|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Gut Permeability in Patients Affected by Obesity and NAFLD: Influence of Ketogenic Diet.
Status: RECRUITING
Conditions: Permeability; Increased|NAFLD|Obesity
Interventions: DIETARY_SUPPLEMENT: Ketogenic Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Family Based Interpersonal Psychotherapy (FB-IPT) for Depressed Preadolescents
Status: COMPLETED
Conditions: Depressive Disorders
Interventions: BEHAVIORAL: Family Based Interpersonal Psychotherapy (FB-IPT)|BEHAVIORAL: Client Centered Therapy (CCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aesthetic Outcome of Complex Linear Closure vs Second Intention Healing: Below the Knee
Status: ENROLLING_BY_INVITATION
Conditions: Wound Heal|Wound of Skin
Interventions: OTHER: Factorial Assignment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Prospective Pilot Study of Robot-assisted Nipple Sparing Mastectomy (RNSM)
Status: ACTIVE_NOT_RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Ductal Breast Carcinoma In Situ|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prophylactic Mastectomy
Interventions: PROCEDURE: Robot-assisted Nipple Sparing Mastectomy|OTHER: Survey Administration|DEVICE: RNSM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: BagEL - Bariatric Patients in Primary Care: Post-operative Nutrition and Lifestyle Management
Status: UNKNOWN
Conditions: Bariatric Surgery Candidate|Malnutrition
Interventions: OTHER: Usability Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study Of The Effect Of PF-04802540 On Sleep Measures
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-04802540|DRUG: PF-04802540|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Zoledronic Acid for Osteoporosis in the Elderly
Status: COMPLETED
Conditions: Osteoporosis|Bone Loss|Fragility Fractures
Interventions: DRUG: Intravenous zoledronic acid|DIETARY_SUPPLEMENT: Vitamin D 800 IU/daily|DIETARY_SUPPLEMENT: Calcium 1200 mg/daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing OUD in Justice-Involved Youth
Status: RECRUITING
Conditions: Substance Use Disorders|Recidivism
Interventions: BEHAVIORAL: Adolescent Community Reinforcement Approach|BEHAVIORAL: Assertive Continuing Care|BEHAVIORAL: Trauma Affect Regulation Guide for Education and Therapy|BEHAVIORAL: Motivational Interviewing|OTHER: Opioid Education Workbook
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Wei Li Bai Capsules in the Treatment of Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: Wei Li Bai capsules|DRUG: Placebo Comparator of Wei Li Bai capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate Safety of GCFLU® Administered Intramuscularly in Healthy Vietnamese Volunteer Aged From 3 Years Old
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: GCFLU® Influenza vaccine (Split virion, Inactivated)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Randomized Clinical Trial of Skin Closure With Staples Versus Suture
Status: COMPLETED
Conditions: Wound Infection|Wound Complication
Interventions: DEVICE: 4-0 monofilament suture|DEVICE: Stainless steel staples
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Withdrawal Symptoms With NADA Acupuncture in Chronic Pain Patients
Status: UNKNOWN
Conditions: Chronic Pain|Opiate Withdrawal Syndrome
Interventions: OTHER: NADA acupuncture|OTHER: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Necrotizing Enterocolitis (Nec) and B. Lactis in Premature Babies
Status: TERMINATED
Conditions: Necrotizing Enterocolitis
Interventions: DIETARY_SUPPLEMENT: Probiotic supplementation|DIETARY_SUPPLEMENT: Milk containing placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial of RAD001 and Neurocognition in Tuberous Sclerosis Complex (TSC)
Status: COMPLETED
Conditions: Tuberous Sclerosis Complex
Interventions: DRUG: RAD001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Doppler Ultrasound Probe for Blood Flow Detection in Severe Upper Gastrointestinal Hemorrhage
Status: COMPLETED
Conditions: UGI Bleeding|Ulcer or Variceal Hemorrhage|Stigmata of Recent Hemorrhage|Endoscopy|Randomized Controlled Trials
Interventions: DEVICE: Doppler endoscopic ultrasound probe for blood flow detection|OTHER: Standard endoscopic hemostasis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Endomicroscopy and Graft-versus-host Disease
Status: UNKNOWN
Conditions: Haematopoietic Stem Cell Transplantation
Interventions: PROCEDURE: Confocal laser endomicroscopy|DEVICE: Confocal Laser Endomicroscope
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Intermittent Dosing Schedule of Imatinib in Patients With Tyrosine Kinase Inhibitor Refractory GISTs
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumors (GISTs)
Interventions: DRUG: Imatinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of a Drug [DCVax (tm)-Prostate] to Treat Prostate Cancer When Hormone Therapy is no Longer Effective.
Status: WITHDRAWN
Conditions: Prostate Cancer
Interventions: DRUG: Dendritic cell immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study
Status: COMPLETED
Conditions: Keratoconus, Unstable|Collagen Crosslinking|Postoperative Pain
Interventions: DRUG: Dextenza|DRUG: Prednisolone Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Monoclonal Antibody Therapy in Treating Patients With Refractory Advanced Solid Tumors or Lymphoma
Status: COMPLETED
Conditions: Lymphoma|Small Intestine Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: etaracizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Biliopancreatic Diversion (BPD)- Duodenal Switch for Superobesity
Status: UNKNOWN
Conditions: Obesity|Diabetes|Hypertension
Interventions: PROCEDURE: Laparoscopic Biliopancreatic diversion with Duodenal switch|PROCEDURE: Laparoscopic Roux-en-Y Gastric Bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TRAC Locus-inserted CD19-targeting STAR-T Cell Therapy in r/r B-NHL
Status: RECRUITING
Conditions: Non-hodgkin Lymphoma,B Cell
Interventions: BIOLOGICAL: Autologous CD19-STAR-T cell|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Skin Thickness Under Treatment With Pimecrolimus 1% Cream, Hydrocortisonacetat 1% Cream, Betamethasonvalerat 0,1% Cream and Clobetasol-17-propionat 0,05% Cream Assessed by Optical Coherence Tomography (OCT) and 20-MHZ Ultrasound
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: pimecrolimus 1% cream|DRUG: hydrocortisonacetat 1% cream|DRUG: betamethasonvalerat 0,1% cream|DRUG: clobetasol-17-propionat 0,05% cream|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2a, Multicenter, Randomized, Double-blind, Parallel Group, Placebo-controlled Trial of IBD98-M
Status: COMPLETED
Conditions: Colitis, Ulcerative
Interventions: DRUG: High dose|DRUG: Low dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve Decongestion Management System (DMS)
Status: RECRUITING
Conditions: Acute Decompensated Heart Failure
Interventions: DEVICE: Reprieve Decongestion Management System|DRUG: Diuretic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AERIAL Trial: Antiplatelet Therapy in Heart Transplantation
Status: RECRUITING
Conditions: Cardiac Allograft Vasculopathy|Heart Transplant
Interventions: DRUG: Placebo|DRUG: aspirin|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: E4Relief (Response to Estetrol in Life Improvement for MEnopausal-associated Hot Flushes)
Status: COMPLETED
Conditions: Hot Flushes
Interventions: DRUG: Estetrol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PRET: Patients Prone to Recurrence After Endovascular Treatment
Status: COMPLETED
Conditions: Intracranial Aneurysm|Subarachnoid Hemorrhage
Interventions: PROCEDURE: endovascular coil embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Quality of Life in Early Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease|Depression
Interventions: DRUG: Carbidopa-Levodopa 25 Mg-100 Mg Oral Tablet|DRUG: Citalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Study of BMS-820836
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: BMS-820836|DRUG: BMS-820836|DRUG: BMS-820836|DRUG: BMS-820836|DRUG: BMS-820836|DRUG: BMS-820836|DRUG: BMS-820836|DRUG: BMS-820836|DRUG: BMS-820836|DRUG: Placebo|DRUG: BMS-820836|DRUG: BMS-820836
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Open-label Study Investigating the Pharmacokinetics and Safety of Aripiprazole IM Depot Formulation (OPC-14597 IMD) During Repeated Administration by Injection Into the Deltoid Muscle in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: OPC-14597 IMD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: First-In-Human Study Evaluating a Novel Catheter Device in Subjects With Treatment-Resistant Hypertension
Status: UNKNOWN
Conditions: Hypertension,Essential
Interventions: DEVICE: Catheter-Based Carotid Body Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of AIN457 in Patients With Rheumatoid Arthritis (RA) Taking Methotrexate (MTX)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Secukinmab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DX-8951f in Treating Children With Advanced Solid Tumors or Lymphomas
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Lymphoma|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: filgrastim|DRUG: exatecan mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Ibrutinib for the Treatment of AIHA in Patients With CLL/SLL or CLL-like MBL
Status: RECRUITING
Conditions: Autoimmune Hemolytic Anemia|Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|Monoclonal B-Cell Lymphocytosis CLL-Type
Interventions: DRUG: Ibrutinib 420 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Evaluation of the Safety and Efficacy of Randomized Placebo Versus the 8-aminoquinoline Tafenoquine for Early Symptom Resolution in Patients With Mild to Moderate COVID 19 Disease and Low Risk of Disease Progression
Status: NOT_YET_RECRUITING
Conditions: COVID 19 Disease|Mild to Moderate COVID 19 Disease|SARS-CoV-2|Infectious Disease|Severe Acute Respiratory Syndrome Coronavirus 2
Interventions: DRUG: Tafenoquine Oral Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Sequenced Strategy for Improving Outcomes in People With Knee Osteoarthritis Pain
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DRUG: Duloxetine|COMBINATION_PRODUCT: Intra-Articular Injection|PROCEDURE: Nerve Procedure with long acting blocks|PROCEDURE: Nerve Procedure with nerve ablation|BEHAVIORAL: Pain Coping Skills Training|OTHER: Best Practices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of TD-1473 in Crohn's Disease
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: DRUG: Placebo|DRUG: TD-1473
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of HMB-enriched Amino Acid Supplementation in Patients With Alcoholic Liver Disease and COVID-19
Status: RECRUITING
Conditions: Alcoholic Liver Disease|COVID 19 Pneumonia
Interventions: DIETARY_SUPPLEMENT: β-hydroxy β-methyl butyrate (HMB) enriched amino acid|DIETARY_SUPPLEMENT: Balanced amino acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prophylactic CD45RA-depleted DLI After Haploidentical Transplantation/RIC
Status: NOT_YET_RECRUITING
Conditions: Hematologic Malignancy|Haplo-identical Stem Cell Transplantation
Interventions: OTHER: CD45RAneg cells, prepared from mononuclear cell leukapheresis by CliniMACS® technology
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Performance and Predictive Capacity of Immediate Urine Cytology After Transurethral Resection of Non-Muscle Invasive Bladder Cancer; A Prospective Study
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DIAGNOSTIC_TEST: immediate urine cytology
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Endoscopic Papillectomy in the Treatment of Ampullary Neoplasms.
Status: RECRUITING
Conditions: Ampullary Adenoma|Ampulla of Vater Adenoma|Ampullary Cancer|Ampulla of Vater Cancer
Interventions: PROCEDURE: Endoscopic Papillectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Selecting Treatment With Desmopressin or Alarm to Children With Enuresis Based on Home Recordings.
Status: COMPLETED
Conditions: Enuresis, Nocturnal
Interventions: DRUG: Desmopressin|DEVICE: Conditional alarm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: AdV-tk Therapy With Surgery and Chemoradiation for Pancreas Cancer (PaTK01)
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma|Pancreatic Cancer
Interventions: BIOLOGICAL: AdV-tk|DRUG: Valacyclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on the Recombinant Hepatitis E Vaccine (Escherichia Coli) (Accelerated Vaccination Schedule)
Status: COMPLETED
Conditions: Hepatitis E
Interventions: BIOLOGICAL: Recombinant Hepatitis E Vaccine (Escherichia Coli)|BIOLOGICAL: Recombinant Hepatitis E Vaccine (Escherichia Coli)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Predictive Value of Glycemic Parameters Measured With the FSL Pro iQ During ACS
Status: RECRUITING
Conditions: Acute Coronary Syndrome|Continuous Glucose Measurement|Glycemic Variability|Cardiovascular Event
Interventions: DEVICE: Freestyle Libre Pro iQ
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Open Study to Evaluate the Safety of Levocetirizine in Young Children (2 - 6 Years) Suffering From Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Levocetirizine oral solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Evaluation of Intravenous Laronidase Pharmacokinetics Before and After Hematopoietic Cell Transplantation in Patients With Mucopolysaccharidosis Type IH.
Status: RECRUITING
Conditions: Hematopoietic Cell Transplantation|Mucopolysaccharidosis Type I
Interventions: DRUG: Laronidase therapy and a stem cell transplant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Docetaxel and S-1 in Head and Neck Squamous Cell Carcinoma (HNSCC)
Status: TERMINATED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: docetaxel+CDDP|DRUG: docetaxel+S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Effectiveness of Corticision Combined by Selfligating Bracket System on the Acceleration of Orthodontic Tooth Movement; A Prospective Clinical Study
Status: NOT_YET_RECRUITING
Conditions: Orthodontic Appliance Complication
Interventions: PROCEDURE: Corticision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Assess The Pharmacokinetics, Safety, And Tolerability Of A Pregabalin Controlled Release Formulation Administered Following Various Sized Caloric Meals As Compared To The Pregabalin Immediate Release Formulation
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 330 mg pregabalin controlled release|DRUG: 330 mg pregabalin controlled release|DRUG: 330 mg pregabalin controlled release|DRUG: 300 mg pregabalin immediate release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries|Neuromodulation
Interventions: DEVICE: Transcutaneous Spinal cord Stimulation|DEVICE: Epidural Spinal Stimulation (ESS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Tomographic Optical Breast Imaging (DBT-TOBI) to Monitor Response to Neoadjuvant Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DEVICE: DBT-TOBI|DEVICE: MRI-TOBI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sequential Transplantation of UCBSCs and Islet Cells in Children and Adolescents With Monogenic Immunodeficiency T1DM
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1|Immunologic Deficiency Syndromes
Interventions: PROCEDURE: Sequential transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Macular Involvement in Diabetic Retinopathy Evaluated With Swept-Source OCT
Status: UNKNOWN
Conditions: Diabetes Mellitus|Diabetic Retinopathy
Interventions: DEVICE: Optical coherence tomography angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Determining an Optimal Weaning Method of Nasal Continuous Positive Airway Pressure in Preterm Neonates
Status: COMPLETED
Conditions: Infant, Newborn|Infant, Premature
Interventions: OTHER: Low CPAP Wean|OTHER: High CPAP Wean
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Investigation Comparing the Clinical Performance and Cost Effectiveness of Biatain® Silicone Compared With SoC
Status: COMPLETED
Conditions: Venous Leg Ulcer|Diabetic Foot Ulcer
Interventions: DEVICE: Biatain® Silicone|DEVICE: Mepilex Border with Aquacel Extra Hydrofiber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TPI Medication Comparison - Ketorolac, Lidocaine, or Dexamethasone
Status: TERMINATED
Conditions: Myofascial Pain
Interventions: DRUG: Ketorolac|DRUG: Lidocaine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study to Evaluate Safety, Tolerability, and Pharmacokinetics of TBI-223 in Healthy Adults
Status: COMPLETED
Conditions: Tuberculosis|Tuberculosis, Pulmonary
Interventions: DRUG: TBI-223 50mg|DRUG: Placebo for TBI-223 50mg|DRUG: TBI-223 100, 300, 600, 1200, 2000, 2600 mg|DRUG: Placebo for TBI-223 100, 300, 600, 1200, 2000, 2600 mg|DRUG: TBI-223 300 mg capsule|DRUG: Placebo for TBI-223 300 mg capsule|DRUG: TBI-223 Prototype 1 SR Tablet|DRUG: TBI-223 Prototype 2 SR Tablet|DRUG: TBI-223 Prototype 3 SR Tablet|DRUG: TBI-223 IR Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Radiographic Evaluation of Guided Tissue Regeneration With Radiation-sterilized Allogenic Bone Grafts or Xenogenic Grafts for the Treatment of Intrabony Defects in Aggressive Periodontitis
Status: UNKNOWN
Conditions: Periodontitis, Aggressive
Interventions: DEVICE: GTR + radiation-sterilize allogenic bone graft|DEVICE: GTR + xenogenic graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of an Exercise Program (STEP) for Youth With Concussion
Status: COMPLETED
Conditions: Persistent Concussion Symptoms
Interventions: BEHAVIORAL: Subthreshold exercise (STEP) with mobile health coaching|BEHAVIORAL: Light stretching (LS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of 0.03% Bimatoprost in the Treatment of Primary Open Angle Glaucoma and Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma, Open-Angle|Ocular Hypertension
Interventions: DRUG: 0.03% Bimatoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validating the Use of a Subjectively Reported Sleep Vital Sign
Status: ACTIVE_NOT_RECRUITING
Conditions: Obstructive Sleep Apnea (OSA)|Insomnia|Restless Leg Syndrome (RLS)|Hypersomnia Type; Sleep Disorder|Shift Work Sleep Disorders
Interventions: OTHER: Sleep VS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Phased Treatment for Social Anxiety Disorder and Coping Behaviors in a Medical Setting
Status: COMPLETED
Conditions: Social Anxiety Disorder|Alcohol Use Disorders
Interventions: BEHAVIORAL: Brief Alcohol Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study of Booster Dose of GSK Biologicals' IPV (Poliorix™) and DTPa/Hib (Infanrix+Hib™) Vaccine
Status: COMPLETED
Conditions: Acellular Pertussis|Tetanus|Diphtheria|Haemophilus Influenzae Type b
Interventions: BIOLOGICAL: Infanrix+Hib™|BIOLOGICAL: Poliorix™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessment of Patient's Satisfaction Regarding the Handiness of Two Hyaluronic Acid Eye Drops Vials
Status: WITHDRAWN
Conditions: Assess the Patient Feeling About the Handiness of Two Different Vials Used to Deliver Both, Unpreserved Hyaluronic Eye Drops
Interventions: DEVICE: HYABAK®|DEVICE: HYLO-COMOD®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Mitigating the Health Effects of Desert Dust Storms Using Exposure-Reduction Approaches
Status: COMPLETED
Conditions: Asthma in Children|Atrial Fibrillation
Interventions: BEHAVIORAL: Intervention (1) for outdoor exposure reduction - Asthma in Children|BEHAVIORAL: Intervention (2) for outdoor and indoor exposure reduction - Asthma in Children|BEHAVIORAL: Intervention (1) for outdoor exposure reduction - Atrial Fibrillation|BEHAVIORAL: Intervention (2) for outdoor and indoor exposure reduction - Atrial Fibrillation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Local Anesthetic Through Continuous Infusion
Status: UNKNOWN
Conditions: Pain Control
Interventions: COMBINATION_PRODUCT: Bupivacaine infusion|COMBINATION_PRODUCT: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT