pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Prospective Randomized Trial Comparing Robotic Versus Open Radical Prostatectomy
Status: TERMINATED
Conditions: Prostatic Neoplasms|Adenocarcinoma
Interventions: PROCEDURE: Robotic Radical Prostatectomy|PROCEDURE: Open Radical Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Efficacy and Safety Study of Adjunctive Perampanel in Primary Generalized Tonic Clonic Seizures
Status: COMPLETED
Conditions: Seizure Disorder Generalized Tonic Clonic
Interventions: DRUG: Perampanel|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Placebo-Controlled Evaluation of Intranasal Dexmedetomidine for Postoperative Analgesia Following Bunionectomy Surgery
Status: COMPLETED
Conditions: Pain, Post-operative
Interventions: DRUG: Intranasal Dexmedetomidine|DRUG: Intranasal Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of SARS-CoV-2 Nanoparticle Vaccine (GBP510) Adjuvanted With or Without AS03 (COVID-19)
Status: UNKNOWN
Conditions: COVID-19 (Healthy Volunteers)
Interventions: BIOLOGICAL: GBP510 adjuvanted with AS03 (RBD 10μg/dose) - Stage 1|BIOLOGICAL: GBP510 (RBD 10μg/dose) - Stage 1|OTHER: Normal saline (0.9% sodium chloride solution) - Stage 1|BIOLOGICAL: GBP510 adjuvanted with AS03 (RBD 25μg/dose) - Stage 1|BIOLOGICAL: GBP510 (RBD 25μg/dose) - Stage 1|OTHER: Normal saline (0.9% sodium chloride solution) - Stage 1|BIOLOGICAL: GBP510 adjuvanted with AS03 (RBD 10μg/dose) - Stage 2|BIOLOGICAL: GBP510 adjuvanted with AS03 (RBD 25μg/dose)- Stage 2|BIOLOGICAL: GBP510 (RBD 25μg/dose)- Stage 2|OTHER: Normal saline (0.9% sodium chloride solution)- Stage 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Telehealth-Enhanced Assessment and Management After Stroke-Blood Pressure
Status: COMPLETED
Conditions: Hypertension Secondary
Interventions: BEHAVIORAL: Intensive Clinic Management (ICM)|BEHAVIORAL: Intensive tailored telehealth management (ITTM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Radioactive Drug (177Lu-DOTATATE) for the Treatment of Locally Advanced, Metastatic, or Unresectable Rare Endocrine Cancers
Status: WITHDRAWN
Conditions: Locally Advanced Adrenal Gland Pheochromocytoma|Locally Advanced Paraganglioma|Metastatic Adrenal Gland Pheochromocytoma|Metastatic Paraganglioma|Metastatic Parathyroid Gland Carcinoma|Pituitary Gland Carcinoma|Somatostatin Receptor Positive|Stage III Thyroid Gland Medullary Carcinoma AJCC v8|Stage IV Thyroid Gland Medullary Carcinoma AJCC v8|Stage IVA Thyroid Gland Medullary Carcinoma AJCC v8|Stage IVB Thyroid Gland Medullary Carcinoma AJCC v8|Stage IVC Thyroid Gland Medullary Carcinoma AJCC v8|Unresectable Adrenal Gland Pheochromocytoma|Unresectable Paraganglioma
Interventions: DRUG: Lutetium Lu 177 Dotatate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise as a Behavioral Treatment for Cocaine Dependence
Status: COMPLETED
Conditions: Cocaine Dependence|Cocaine Addiction|Cocaine Abuse|Substance Abuse
Interventions: BEHAVIORAL: Sitting|BEHAVIORAL: Running|BEHAVIORAL: Walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Everolimus and Octreotide Acetate With or Without Bevacizumab in Treating Patients With Locally Advanced or Metastatic Pancreatic Neuroendocrine Tumors That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Advanced Pancreatic Neuroendocrine Tumor|Locally Advanced Pancreatic Neuroendocrine Tumor|Pancreatic Gastrinoma|Pancreatic Neuroendocrine Tumor G1|Pancreatic Neuroendocrine Tumor G2|Pancreatic Vipoma
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Everolimus|DRUG: Octreotide Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypertension, Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Standard Care|DRUG: Intensive Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Long-Term Follow-Up Of Surgical Management Of Early Onset Scoliosis Using Growing Rods
Status: UNKNOWN
Conditions: Early-Onset Scoliosis Deformity of Spine
Interventions: PROCEDURE: Growing Rods
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diclofenac IM Versus Tramadol IV in Acute Renal Colic, RCT
Status: COMPLETED
Conditions: Acute Renal Colic
Interventions: DRUG: Diclofenac/Tramadol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Robot-assisted ICG-guided Sentinel Node Biopsy in Testicular Cancer
Status: RECRUITING
Conditions: Germ Cell Tumor|Seminoma|Nonseminomatous Germ Cell Tumor
Interventions: PROCEDURE: Robot-assisted ICG-guided sentinel lymph node biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postprandial Effects of Mixed Herbs and Spices on Pathways Associated With Glucose Homeostasis and Inflammation on PBMCs of Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: High fat challenge breakfast|OTHER: High fat challenge breakfast with mixed-spices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Non-Operative Management and Early Response Assessment in Rectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Adenocarcinoma of the Lower Rectum
Interventions: RADIATION: Radiation therapy|DRUG: FOLFOX regimen|OTHER: Functional Assessment of Cancer Therapy-Colorectal cancer (FACT-C) questionnaire|PROCEDURE: Rectal biopsy samples|PROCEDURE: Blood for ctDNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of GST-HG171/Ritonavir Compared With Placebo in Patients With Mild to Moderate COVID-19
Status: COMPLETED
Conditions: COVID-19 Pneumonia
Interventions: DRUG: GST-HG171/Ritonavir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of >Your< Iron Syrup Supplementation in Children With Dietary Iron Deficiency
Status: COMPLETED
Conditions: Iron-deficiency
Interventions: DIETARY_SUPPLEMENT: >Your< Iron Syrup|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Phase 3 Study of LJPC-501 in Patients With Catecholamine-Resistant Hypotension
Status: COMPLETED
Conditions: Catecholamine-resistant Hypotension (CRH)|Distributive Shock|High Output Shock|Sepsis
Interventions: DRUG: LJPC-501|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adding Mitomycin to BCG as Adjuvant Intravesical Therapy for High-risk Non-Muscle-invasive Bladder Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Bladder Cancer
Interventions: BIOLOGICAL: Bacillus of Calmette-Guerin (BCG)|DRUG: Mitomycin (MM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Photo-biomodulation in the Treatment of Chemotherapy Induced Mucositis
Status: COMPLETED
Conditions: Mucositis
Interventions: DEVICE: Simpler diode laser|DRUG: Conventional symptomatic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Consensual Social Skills to Prevent Non-consensual Sexual Acts
Status: ENROLLING_BY_INVITATION
Conditions: Paraphilias and Paraphilic Disorders
Interventions: BEHAVIORAL: Social skills group psychotherapy|BEHAVIORAL: Adult interest group psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine Whether an Oral Drops Formulation of Triazolam is Bioequivalent to a Tablet Formulation in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: triazolam liquid oral drops|DRUG: triazolam tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Hetrombopag on the Pharmacokinetics of Rosuvastatin in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Rosuvastatin|DRUG: Hetrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sunitinib Malate With Hormonal Ablation for Patients Who Will Have Prostatectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: LHRH Agonist|DRUG: Sunitinib Malate|PROCEDURE: Radical Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Smartphone-assisted Hybrid Cardiac Rehabilitation Program in Patients With Heart Failure.
Status: RECRUITING
Conditions: Heart Failure
Interventions: OTHER: smartphone-assisted hybrid cardiac rehabilitation (SHCR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Doxorubicin in Patients With Metastatic Breast Cancer/Advanced Ovarian Cancer
Status: COMPLETED
Conditions: Breast Cancer and Ovarian Cancer
Interventions: DRUG: SPARC-08-038|DRUG: Ref-08-038
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: |Primary Purpose: TREATMENT
Clinical trial: OCT-guided LALAK in Children
Status: TERMINATED
Conditions: Corneal Opacity
Interventions: PROCEDURE: OCT guided laser-assisted lamellar anterior keratoplasty (LALAK)|PROCEDURE: Penetrating Keratoplasty (KP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stenting in Renal Dysfunction Caused by Atherosclerotic Renal Artery Stenosis
Status: COMPLETED
Conditions: Renal Artery Obstruction|Kidney Failure
Interventions: DEVICE: Renal artery stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Root Biomodification With Citric Acid and Tetracycline Improves the Outcomes of Root Coverage
Status: COMPLETED
Conditions: Gingival Recession
Interventions: OTHER: Root conditioning with citric acid+tetracycline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Compare Two Surgical Approaches to the Cochlea
Status: NOT_YET_RECRUITING
Conditions: Cochlear Implants|Hearing Loss, Sensorineural
Interventions: PROCEDURE: Surgical approach: cochleostomy or extended round window
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Skin Glues Compared to Running Sutures for Perineal Skin Repair After Vaginal Delivery. A Randomized Controlled Trial
Status: RECRUITING
Conditions: Perineal Tear
Interventions: DEVICE: exofin®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Efficacy of Add on Selenium in Mild-to-moderate Graves Ophthalmopathy
Status: NOT_YET_RECRUITING
Conditions: Thyroid Eye Disease|Graves Ophthalmopathy
Interventions: DRUG: Selenium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Development of a Human Model of Respiratory Syncytial Virus Infection
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections|Respiratory Viral Infections
Interventions: BIOLOGICAL: RSV A Memphis 37
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Safety and Efficacy of Biolimus in the Treatment of Patients With in Stent Restenosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: Biolimus|DEVICE: SeQuent® Please Neo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abdominal-Kegel Exercise and the Effect of Telemedicine in Stress Urinary Incontinence
Status: ENROLLING_BY_INVITATION
Conditions: Stress Urinary Incontinence
Interventions: OTHER: Group administered to individual telemedicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Can Mindfulness and Self-monitoring Improve Control Over Maladaptive Daydreaming?
Status: COMPLETED
Conditions: Internet-Based Intervention|Psychological Intervention|Intervention Study
Interventions: OTHER: Online therapeutic intervention for maladaptive daydreaming based on mindfulness and self-monitoring|OTHER: Online therapeutic intervention for maladaptive daydreaming based on mindfulness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetics (PK) Study of the Effects Rabeprazole and Rifampin on Dabrafenib in Subjects With BRAF V600 Mutation Positive Tumors
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Dabrafenib 150 mg twice a day (BID)|DRUG: Rabeprazole 40 mg once daily (OD)|DRUG: Rifampin 600 mg OD
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Iodopovidone Versus Talc in Palliative Malignant Pleural Effusion
Status: COMPLETED
Conditions: Malignant Pleural Effusion
Interventions: DRUG: Iodopovidone solution|DRUG: Talc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CATER: Comprehensive Alveolar and Tooth Esthetic Replacement
Status: COMPLETED
Conditions: Dental Implant Failure Nos
Interventions: DEVICE: Allograft mucosal enhancement with dental implant|DEVICE: No allograft mucosal enhancement at time of dental implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intergenerational Behavioral Intervention to Enhance Physical Activity in Older Adults at Risk for Alzheimer's Disease
Status: RECRUITING
Conditions: Physical Inactivity
Interventions: BEHAVIORAL: Motivational behavioural intervention and daily activities monitoring|BEHAVIORAL: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Réa-MiniMax: Severe Acute Respiratory Failure in Hematology and Cancer Patients Without Bronchoalveolar Lavage
Status: COMPLETED
Conditions: Lymphoma|Cancer|Acute Respiratory Failure|Leukemia
Interventions: PROCEDURE: Fiberoptic bronchoscopy and bronchoalveolar lavage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Pyrotinib Plus Capecitabine in HER2-positive MBC With Active Brain Metastases That Have Failed ADCs
Status: NOT_YET_RECRUITING
Conditions: Metastatic Breast Cancer in the Brain
Interventions: DRUG: pyrotinib plus capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Six-month Study to Compare the Effects of Volume- and Pressure-Guided Adjustments on Weight Loss and Satiety
Status: COMPLETED
Conditions: Morbid Obesity
Interventions: DEVICE: Intraband pressure recording system|OTHER: Conventional Adjustment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quadratus Lumborum Block Versus Thoracic Paravertebral Block
Status: UNKNOWN
Conditions: Postoperative Analgesia
Interventions: COMBINATION_PRODUCT: Ultrasound guided quadratus lumborum block|COMBINATION_PRODUCT: Ultrasound guided thoracic paravertebral block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeted Therapy in Treating Patients With Incurable Non-Small Cell Lung Cancer With Genetic Mutations
Status: TERMINATED
Conditions: EGFR Activating Mutation|Recurrent Non-Small Cell Lung Carcinoma|Stage IV Non-Small Cell Lung Cancer
Interventions: DRUG: Chemotherapy|BIOLOGICAL: Immunotherapy|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Nivolumab|BIOLOGICAL: Pembrolizumab|DRUG: Targeted Molecular Therapy|DRUG: Tyrosine Kinase Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study on the Treatment of Recurrent/Refractory/Intolerable NSAA With Lusutrombopag
Status: NOT_YET_RECRUITING
Conditions: Aplastic Anemia
Interventions: DRUG: Lusutrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation Of Innovative 3D Printed Space Maintainer Versus Conventional One
Status: UNKNOWN
Conditions: Missing Teeth
Interventions: DEVICE: 3D printed space maintainer by NextDent Ortho Rigid|DEVICE: Conventional Band and Loop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Seaweed Extract Supplementation and Metabolic Biomarkers
Status: COMPLETED
Conditions: Metabolic Syndrome|Insulin Sensitivity
Interventions: DIETARY_SUPPLEMENT: Seaweed extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intraoperative Diastolic Function by TDI and STE
Status: COMPLETED
Conditions: Echocardiography, Doppler|Echocardiography, Three-Dimensional|Echocardiography, Transesophageal|Echocardiography, Transthoracic
Interventions: OTHER: TTE Apical 4 Chamber View|OTHER: TEE dTG View|OTHER: TEE ME 4C View
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Efficacy, Safety, and Tolerability of Probiotics on the Mood and Cognition of Depressed Patients
Status: COMPLETED
Conditions: Major Depressive Disorder|Depression|Depressive Symptoms
Interventions: DIETARY_SUPPLEMENT: Probio'Stick
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induced Sputum Versus Bronchoscopy in Smear Negative Pulmonary Tuberculosis
Status: COMPLETED
Conditions: Pulmonary Tuberculosis
Interventions: PROCEDURE: Diagnostic techniques in pulmonary tuberculosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Genicular Nerve Block and Intraarticular Injection for Postoperative Pain in Knee Arthroscopy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: intra-articular injection|PROCEDURE: genicular nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment Based on Molecular Profiling Diagnosis Carcinoma of Unknown Primary Site
Status: COMPLETED
Conditions: Carcinoma
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Bevacizumab|DRUG: Erlotinib|OTHER: Treatment determined by physician
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Printing Layer Thickness on the Accuracy of Computer Aided Surgical Guides
Status: UNKNOWN
Conditions: Guided Surgery
Interventions: DEVICE: computer aided surgical guide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Normal Oxygenation Versus Hyperoxia in the Intensive Care Unit (ICU)
Status: UNKNOWN
Conditions: Nervous System Diseases|Respiratory Tract Diseases|Cardiovascular Diseases|Immune System Diseases
Interventions: DRUG: Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Oral Verses Patch Trial In Menopausal Women - Individualisation of Oestrogen Therapy
Status: UNKNOWN
Conditions: Venous Thrombosis|Insulin Resistance
Interventions: DRUG: Femoston Conti|DRUG: EVOREL® CONTI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Study of Lenalidomide in Combination With Oral Dexamethasone in the Treatment of Previously Untreated, Symptomatic Patients With Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Lenalidomide and Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Algorithm Guided DBS Programming in Parkinson's Patients
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: StimSearch programming algorithm software|DEVICE: Clinician based programming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of SAGE-904 Using a Ketamine Challenge to Evaluate Electrophysiology, Safety, Tolerability, and Pharmacokinetics in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: SAGE-904|DRUG: Placebo|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postprandial IHL and IMCL Measured With Proton Magnetic Resonance Spectroscopy
Status: COMPLETED
Conditions: Postprandial IHL and IMCL Dynamics
Interventions: DIETARY_SUPPLEMENT: High fat breakfast|DIETARY_SUPPLEMENT: HF breakfast with protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase Ⅳ Clinical Trial of the Recombinant Hepatitis E Vaccine (Escherichia Coli)(Coadministration With Recombinant Hepatitis B Vaccine)
Status: COMPLETED
Conditions: Hepatitis E|Hepatitis B
Interventions: BIOLOGICAL: HEV vaccine|BIOLOGICAL: HBV vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nutritional and Physical Exercise Intervention in Older Patients With Malignant Hemopathies
Status: UNKNOWN
Conditions: Hematologic Malignancy|Old Age; Debility
Interventions: OTHER: Nutritional support|OTHER: Physical exercise|DRUG: Hematologic Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hybrid Argon Plasma Coagulation and Endoscopic Sleeve Gastroplasty Validation Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: PROCEDURE: Hybrid Argon Plasma Coagulation|PROCEDURE: Endoscopic Sleeve Gastroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhanced Recovery After Surgery in Oblique Lumbar Interbody Fusion
Status: COMPLETED
Conditions: Enhanced Recovery After Surgery|Spinal Fusion|Lumbar Spinal Stenosis|Lumbar Spondylolisthesis
Interventions: BEHAVIORAL: Enhanced Recovery After Surgery program for Oblique Lumbar Interbody Fusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Early Conversion From CNI to Belatacept in Renal Transplant Recipients With Delayed and Slow Graft Function
Status: UNKNOWN
Conditions: Delayed Graft Function|Kidney Transplant
Interventions: DRUG: Belatacept|DRUG: Calcineurin Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HLA Typing & Tumor Neoantigen Identification for Phase I/II Study of Autologous TCR-T Cells in Subjects With Solid Tumors
Status: SUSPENDED
Conditions: Ovarian Cancer|Endometrial Cancer|Colo-rectal Cancer|Cholangiocarcinoma|Non-small Cell Lung Cancer|Pancreas Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 1/2 Study of CD19 Chimeric Antigen Receptor T-cell (CD19 CAR-T; PL001) for Relapsed or Refractory B-cell Lymphoma
Status: RECRUITING
Conditions: Diffuse Large B Cell Lymphoma|Primary Mediastinal Large B Cell Lymphoma|Large B-cell Lymphoma|Follicular Lymphoma Grade 3A|Follicular Lymphoma Grade 3B
Interventions: BIOLOGICAL: CD19-targeted chimeric antigen receptor T-cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Patients With Advanced Parkinson's Disease to Assess the Relative Bioavailability of Levodopa Administered as ND0612 Subcutaneous Infusion Versus Levodopa Administered as Carbidopa-Levodopa Enteral Suspension
Status: WITHDRAWN
Conditions: Parkinson
Interventions: COMBINATION_PRODUCT: ND0612|COMBINATION_PRODUCT: CLES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Hypoallergenicity of a New Extensively Hydrolyzed Formula
Status: COMPLETED
Conditions: Cow's Milk Allergy
Interventions: OTHER: Test extensively hydrolyzed formula|OTHER: Control extensively hydrolyzed formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Clinical Study of Puesta Mesylate for Injection in Patients With Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: A group Purinostat Mesylate 6mg/m2|DRUG: A group Purinostat Mesylate 8.4mg/m2|DRUG: A group Purinostat Mesylate 11.2mg/m2|DRUG: A group Purinostat Mesylate 15.0mg/m2|DRUG: B group Purinostat Mesylate 6.0mg/m2|DRUG: B group Purinostat Mesylate 8.4 mg/m2|DRUG: B group Purinostat Mesylate 11.2 mg/m2|DRUG: B group Purinostat Mesylate 15.0 mg/m2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adherence to Lung Cancer Screening by Low-dose Thoracic CT in Haut-Rhin Department, France.
Status: RECRUITING
Conditions: High-Risk Cancer|Lung Cancer
Interventions: PROCEDURE: Low Dose chest CT Scan for Lung Cancer Screening
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Upper Facial Remodeling With Perlane-L and Dysport
Status: COMPLETED
Conditions: Mild to Moderate Temporal Atrophy|Moderate to Severe Glabellar Rhytids|Moderate to Severe Periorbital Rhytids
Interventions: DRUG: Dysport|DEVICE: Perlane L
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers in Samples From Patients With Follicular Lymphoma Treated With Rituximab
Status: COMPLETED
Conditions: Lymphoma
Interventions: GENETIC: gene expression analysis|GENETIC: microarray analysis|GENETIC: polymerase chain reaction|GENETIC: polymorphism analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Methylprednisolone on Quadriceps Muscle Function in Patients Undergoing Total Knee-arthroplasty
Status: COMPLETED
Conditions: Osteoarthrosis
Interventions: DRUG: Methylprednisolone|DRUG: Isotonic Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Tislelizumab or Tislelizumab Combined With Lenvatinib Neo-adjuvant Treatment for Resectable RHCC
Status: RECRUITING
Conditions: Recurrent Hepatocellular Carcinoma
Interventions: DRUG: Tislelizumab|DRUG: Tislelizumab combined with Levatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxfordshire Sedentariness, Obesity & Cardiometabolic Risk in Adolescents - a Trial of Exercise in Schools
Status: UNKNOWN
Conditions: Overweight/Obesity, Adolescent
Interventions: OTHER: Intervention Group|OTHER: Sham-Exercise Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Self-operated Endo-vaginal Telemonitoring (SOET), an Economic and Patient-empowered Method for Ovarian Stimulation for In-vitro Fertilization (IVF)
Status: COMPLETED
Conditions: IVF Treatment
Interventions: DEVICE: Perform Echo at home.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage II, IIIA, and Resectable IIIB (T3-4N2) Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Placebo|DRUG: Cisplatin|DRUG: Gemcitabine|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Elimination Of Distal Coronary Sinus-Left Atrial Connections for Atrial Fibrillation Ablation Trial
Status: UNKNOWN
Conditions: Atrial Fibrillation|Arrhythmias, Cardiac
Interventions: PROCEDURE: Standard Atrial fibrillation ablation|PROCEDURE: Coronary sinus to left atrium connection elimination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Neuromuscular Monitoring and Reducing Residual Neuromuscular Blockade Via E-learning
Status: COMPLETED
Conditions: Neuromuscular Blockade
Interventions: OTHER: E-learning course in neuromuscular monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety
Status: COMPLETED
Conditions: Healthy|Pharmacokinetics|Pharmacodynamics|Ilaprazole
Interventions: DRUG: Ilaprazole|DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Self-Management for Head and Neck Lymphedema and Fibrosis [PROMISE Trial]
Status: RECRUITING
Conditions: Lymphedema of the Head and Neck
Interventions: BEHAVIORAL: Usual Care|BEHAVIORAL: In-Person LEF-SMP|BEHAVIORAL: Telehealth LEF-SMP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Calf Deep Vein Thrombosis Treatment Trial
Status: TERMINATED
Conditions: Deep Vein Thrombosis
Interventions: DRUG: Apixaban|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Escitalopram on Sperm DNA Fragmentation
Status: RECRUITING
Conditions: Sperm DNA Fragmentation|Infertility, Male
Interventions: DRUG: Escitalopram|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Intravitreal Ranibizumab in the Treatment of Vitreous Hemorrhage
Status: UNKNOWN
Conditions: Diabetic Retinopathy|Vitreous Hemorrhage
Interventions: DRUG: intravitreal ranibizumab injections
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gait Training For Acute Stroke: Functional Neuromuscular Stimulation (FNS) and Weight Supported Treadmill Training
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Electrical Stimulation with Intramuscular Electrodes|PROCEDURE: Body Weight Supported Treadmill Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Uniform Multidrug Therapy Regimen for Leprosy Patients
Status: COMPLETED
Conditions: Leprosy
Interventions: DRUG: PB 6 doses - Rifampicin and Dapsone|DRUG: PB 6 doses - Rifampicin, Clofazimine and Dapsone|DRUG: MB 12 doses - Rifampicin, Clofazimine and Dapsone|DRUG: MB 6 doses - Rifampicin, Clofazimine and Dapsone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Gradually Increasing Force Magnitude on the Rate of Canine Retraction Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Canine Retraction
Interventions: OTHER: Gradual increase of force
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Evaluation of ALT-2074 in Subjects With Type-2 Diabetes, Haptoglobin Type 2-2 Genotype and Coronary Artery Disease
Status: COMPLETED
Conditions: Diabetes|Coronary Artery Disease
Interventions: DRUG: ALT-2074
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Ultra-early Identification of Fetal Chromosomal Characteristics From Extravillous-trophoblast Cells
Status: NOT_YET_RECRUITING
Conditions: Pregnant Women
Interventions: PROCEDURE: Inclusion (Visit 1 - Week 7-16)|DIAGNOSTIC_TEST: Second semester of pregnancy (Visit 2 - Week 20-24)|DIAGNOSTIC_TEST: Third semester of pregnancy (Visit 3- Week 34)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: QUILT-3.076: Study of Autologous M-CENK in Subjects With Locally Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Metastatic Solid Tumor
Interventions: BIOLOGICAL: M-CENK, Suspension for Infusion, Cryopreserved (M-CENK) (Cohort 2 part B)|BIOLOGICAL: N-803 (Cohort 2 part B)|OTHER: Apheresis collection of MNCs (part A)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nurses' Knowledge and Attitude About Opioids
Status: COMPLETED
Conditions: Opioid Use, Unspecified|Nurse's Role|Knowledge, Attitudes, Practice
Interventions: OTHER: Evaluation of nurses' knowledge and attitudes about opioid analgesics working in a university hospital
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: MRD/Risk-oriented Therapy of Adult Ph- ALL Including Pegylated Asparaginase and Lineage-targeted Methotrexate
Status: COMPLETED
Conditions: Untreated Philadelphia Positive Acute Lymphoblastic Leukemia|De Novo|Secondary|Low-dose Corticosteroids Pretreatment
Interventions: DRUG: Prephase PDN + CY|DRUG: Cycle 1 Induction|DRUG: Cycle 2 Induction / Early consolidation|DRUG: Cycle 3 Early consolidation|DRUG: Cycle 4 Consolidation|DRUG: Cycle 5 Consolidation|DRUG: Cycle 6 Consolidation|DRUG: Cycle 7 Consolidation|DRUG: Cycle 8 Reinduction|DRUG: Maintenance|PROCEDURE: Allogeneic SCT or Autologous SCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Localization of Sentinel Lymph Node in Breast Cancer Patients By Novel Computed Tomography-Lymphography Guided Technique
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DEVICE: preoperative localization of SLN detected by CTLG by either methods
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Inadequately Controlled Moderate to Severe Asthma
Status: RECRUITING
Conditions: Moderate to Severe Asthma
Interventions: DRUG: povorcitinib|OTHER: placebo|DRUG: ICS-LABA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dupilumab and House Dust Mite Immunotherapy in Patients With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: BIOLOGICAL: tablets Acarizax|BIOLOGICAL: dupilumab|DRUG: cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Calcium in Pregnant Women With Hypertension
Status: COMPLETED
Conditions: Cardiovascular Diseases|Heart Diseases|Hypertension|Pre-Eclampsia|Pregnancy Toxemias|Vascular Diseases
Interventions: BEHAVIORAL: dietary supplements|DRUG: calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Efficacy, Safety, and Pharmacokinetics of ABP-671 in Patients With Gout or Hyperuricemia
Status: COMPLETED
Conditions: Gout|Hyperuricemia
Interventions: DRUG: ABP-671|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Yoga for Treating Geriatric Insomnia
Status: COMPLETED
Conditions: Primary Geriatric Insomnia|Sleep Initiation and Maintenance Disorders
Interventions: OTHER: Integrated Yoga style practice
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Zevalin Plus BuCyE High-dose Therapy in B-cell Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Zevalin-BuCyE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Korean Red Ginseng Rg3 Extract on Arterial Stiffness and Blood Pressure
Status: COMPLETED
Conditions: Arterial Stiffness, Blood Pressure
Interventions: DIETARY_SUPPLEMENT: Ginseng|DIETARY_SUPPLEMENT: Wheat Bran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telehealth CBT for Adolescents and Young Adults With Childhood-onset Systemic Lupus Erythematosus
Status: ACTIVE_NOT_RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: BEHAVIORAL: TEACH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility of Using a Single Transradial Guiding Catheter for Primary PCI
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: PROCEDURE: guiding catheter|PROCEDURE: diagnostic catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder
Status: UNKNOWN
Conditions: Bipolar Disorder
Interventions: DRUG: quetiapine fumarate tablet (Seroquel)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral FMT (Fecal Microbial Transplant) in Subjects With Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis
Interventions: BIOLOGICAL: Fecal microbial transplant (FMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deep Brain Stimulation of the Amygdala for Combat Post-Traumatic Stress Disorder
Status: RECRUITING
Conditions: Posttraumatic Stress Disorder
Interventions: PROCEDURE: DBS of the Basolateral Nucleus of the Amygdala|DEVICE: Medtronic Activa PC DBS of the Basolateral Nucleus of the Amygdala
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of KLS-1 Monotherapy in Malignant Neoplasms
Status: ACTIVE_NOT_RECRUITING
Conditions: CLL|Solid Tumor, Adult
Interventions: DRUG: Zinc-64 Aspartate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Efficacy, Safety & Subject Satisfaction of Pain Management With Pliaglis® Cream for Dermal Filler Injections
Status: TERMINATED
Conditions: Nasolabial Folds
Interventions: DRUG: tetracaine 7% / lidocaine 7% cream (Pliaglis® Cream)|DRUG: benzocaine 20% / lidocaine 6% / tetracaine 4% ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MEK Inhibitor Mirdametinib (PD-0325901) in Patients With Neurofibromatosis Type 1 Associated Plexiform Neurofibromas
Status: ACTIVE_NOT_RECRUITING
Conditions: Plexiform Neurofibroma|Neurofibromatosis Type 1 (NF1)
Interventions: DRUG: Mirdametinib (PD-0325901) oral capsule or dispersible tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stenting and Resection for Stage IV Colorectal Cancer Endoscopic Stenting and Colorectal Resection in Stage IV
Status: UNKNOWN
Conditions: Colorectal Neoplasm
Interventions: PROCEDURE: ENDOSCOPIC PLACEMENT OF EXPANDABLE STENT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Potential of Stannous Fluoride Toothpaste to Reduce Gum Disease
Status: COMPLETED
Conditions: Gingivitis
Interventions: DRUG: Stannous Fluoride|DRUG: Sodium Monofluorophosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Vitamin D3 Therapy in Post Menopausal Women and Assessment of Changes in Bone Mineral Density After Orally Vitamin D3 Administration
Status: UNKNOWN
Conditions: Vitamin D Deficiency
Interventions: DRUG: Oral administration of vitamin D3|DRUG: Vitamin D3 50000 UNT Oral Capsule|DIETARY_SUPPLEMENT: milk, Dietary and life style modifications.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Safety and Efficacy of Four-Point Scleral Intraocular Lens Fixation and Yamane Techniques
Status: COMPLETED
Conditions: Aphakia
Interventions: PROCEDURE: Four-point scleral fixation of Akreos AO60 IOL|PROCEDURE: Sutureless scleral fixation of AcrySof MA60AC IOL with Yamane technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study to Determine the Effect of Mifepristone on the Pharmacokinetics of Fluvastatin in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: mifepristone + fluvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bortezomib in KRAS-Mutant Non-Small Cell Lung Cancer in Never Smokers or Those With KRAS G12D
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Bortezomib|DRUG: Acyclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Furmonertinib in Patients With EGFR Mutations in Advanced NSCLC With Brain Metastases: A Single-center, Open-label, Phase II Trial（iFORCE）
Status: UNKNOWN
Conditions: Furmonertinib|EGFR-mutation|NSCLC|Brain Metastases
Interventions: DRUG: Furmonertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT