pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Circulating Tumor DNA Based Adjuvant Chemotherapy in Stage II Colon Cancer Patients: the MEDOCC-CrEATE Trial
Status: RECRUITING
Conditions: Circulating Tumor DNA|Recurrence|Colon Cancer Stage II
Interventions: OTHER: ctDNA analysis after surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Protection Activity of Microfine Titanium Dioxide (Ti02), Pigmentary Ti02 and Bisoctrizole and Their Combinations in Voluntary Patients With Idiopathic Solar Urticaria (SU)
Status: COMPLETED
Conditions: Idiopathic Solar Urticaria
Interventions: DRUG: Titanium dioxide (Ti02) microfine 12.15% alone (formula RV3131A-MV1209)|DRUG: Ti02 pigmentary 3% alone (formula RV3131A-MV1211)|DRUG: bisoctrizole 10% alone (formula RV3131A-MV1237)|DRUG: Ti02 microfine 12.15% + Ti02 pigmentary 3% (formula RV3131A-MV1213)|DRUG: Ti02 microfine 12.15% + bisoctrizole 10% (formula RV3131A-MV1329)|DRUG: Ti02 pigmentary 3% + bisoctrizole 10% (formula RV3131A-MV1212)|DRUG: Ti02 microfine 12.15% + Ti02 pigmentary 3% + bisoctrizole 10% [V0096 CR (formula RV3131A-MV1166)]|DRUG: V0096 CR vehicle (formula RV3131A-MV1197)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Relative Bioavailability Study of Mirtazapine 15 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Mirtazapine 15 mg tablets, single dose|DRUG: REMERON® 15 mg tablets, single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Study to Assess How Itraconazole Affects the Uptake and Elimination of Capivasertib in the Body
Status: COMPLETED
Conditions: Healthy Volunteers (Intended Indication: Metastatic Patients With Triple Negative or HR+ Breast Cancer, or Hormone Sensitive Prostate Cancer)
Interventions: DRUG: Capivasertib|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Persistent Atrial Fibrillation (AF) APAC (Asia Pacific) Observational Study
Status: TERMINATED
Conditions: Persistent Atrial Fibrillation
Interventions: DEVICE: TactiCath™ Contact Force Ablation Catheter, Sensor Enabled™ (TactiCath SE)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Computer-based Prescription Opioid Abuse Prevention for Adolescents
Status: COMPLETED
Conditions: Opioid Related Disorders
Interventions: BEHAVIORAL: Web-based prescription opioid prevention for adolescents|BEHAVIORAL: JustThinkTwice.gov website (DEA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Hydrogen's Feasibility and Safety as a Therapy in ECPR
Status: RECRUITING
Conditions: Cardiac Arrest|Extracorporeal Membrane Oxygenation|Reperfusion Injury
Interventions: DRUG: Hydrogen|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intravenous and Subcutaneous Single and Repeated Doses of SAR441344 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: SAR441344|DRUG: placebo|BIOLOGICAL: Keyhole limpet hemocyanin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diffuse Fibrotic Lung Disease
Status: COMPLETED
Conditions: Lung Diseases|Pulmonary Fibrosis|Sarcoidosis
Interventions: DRUG: prednisone|DRUG: cyclophosphamide|DRUG: dapsone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparison of Effects of Vestibular Visual Cues and Proprioception To Improve Postural Control in Elderly
Status: COMPLETED
Conditions: Older Adults
Interventions: OTHER: vestibular visual cues therapy|OTHER: propriocetion exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of RAD001 in Patients With Relapsed/Refractory Hodgkin Lymphoma That Has Progressed After High-dose Chemotherapy and Autologous Stem Cell Transplant and/or After Gemcitabine- or Vinorelbine- or Vinblastine-based Treatment.
Status: COMPLETED
Conditions: Hodgkin Lymphoma
Interventions: DRUG: Everolimus (RAD001)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sirolimus-Eluting Stents for Chronic Total Coronary Occlusions
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Disease|Coronary Stenosis
Interventions: DEVICE: sirolimus-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Single Dose Escalation Study of PF-05190457 in Healthy Volunteers
Status: COMPLETED
Conditions: Diabetes Mellitus, Type II
Interventions: DRUG: PF-05190457|DRUG: PF-05190457|DRUG: PF-05190457|DRUG: PF-05190457|DRUG: PF-05190457|DRUG: PF-05190457|DRUG: PF-05190457|DRUG: PF-05190457|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Leramistat in Patients With IPF
Status: RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Leramistat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Walking Exercise on Sleep Quality in Sedentary Healthy Adults
Status: COMPLETED
Conditions: Walking|Sleep|Stress, Psychological|Lifestyle, Sedentary|Life Change Events
Interventions: BEHAVIORAL: Aerobic walking intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase II Trial of Pembrolizumab in Metastatic or Locally Advanced Anaplastic/Undifferentiated Thyroid Cancer
Status: RECRUITING
Conditions: Thyroid Cancer
Interventions: DRUG: Pembrolizumab (Keytruda)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Creation of Arteriovenous Ante-brachial Fistula Under Axillary Block Versus Local Anesthesia : Impact on Early Complications
Status: COMPLETED
Conditions: Kidney Failure, Chronic
Interventions: DRUG: Axillary block anesthesia with Ropivacaine and Lidocaine|DRUG: Local anesthesia with Ropivacaine and Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Comparison of Two Treatment Strategies in Older Participants With Type 2 Diabetes Mellitus (T2DM)
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Glimepiride|DRUG: Metformin|DRUG: Pioglitazone|DRUG: Acarbose|DRUG: Linagliptin|DRUG: Sitagliptin|DRUG: Liraglutide|DRUG: Insulin Glargine|DRUG: Exenatide once weekly (QW)|DRUG: Exenatide twice daily (BID)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Stage III or Stage IV Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: synthetic breast cancer peptides-tetanus toxoid-Montanide ISA-51 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anastomotic Leak Testing in Gastrectomy
Status: COMPLETED
Conditions: Anastomotic Leak|Gastric Cancer|Surgery|Testing, Reality|Gastroscopy
Interventions: PROCEDURE: Introperative leak testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: GR-MD-02 + Pembrolizumab Versus Pembrolizumab Monotherapy in Melanoma and Squamous Cell Head and Neck Cancer Patients
Status: WITHDRAWN
Conditions: Metastatic Melanoma|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: GR-MD-02|DRUG: Placebo|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Motivational Interviewing Applied to Individuals With Diabetes
Status: RECRUITING
Conditions: Motivational Interviewing|Stress|Well-Being, Psychological|Diabetes Mellitus|Type2diabetes
Interventions: BEHAVIORAL: motivational interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study Evaluating Antibiotic Utilization Measures and Control of Extended-Spectrum-Lactamases (ESBLs)
Status: COMPLETED
Conditions: Bacterial Infection
Interventions: DRUG: Extended-Spectrum-Lactamases (ESBLs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nucleic Acid Amplification Tests (NAATs) for the Diagnosis of Pharyngeal and Rectal Chlamydia and Gonorrhea Infections
Status: COMPLETED
Conditions: Chlamydia Infections|Gonorrhea
Interventions: DEVICE: Nucleic acid amplification test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Buteyko Technique and Pursed Lip Breathing in Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: OTHER: Buteyko Breathing exercises|OTHER: Pursed lip breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of GC4419 in Patients With Critical Illness Due to COVID-19
Status: TERMINATED
Conditions: Covid19|SARS-CoV-2 Infection
Interventions: DRUG: GC4419|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neurally Targeted Cognitive Training to Augment CBT Outcomes in Pediatric Anxiety
Status: COMPLETED
Conditions: Anxiety Disorders
Interventions: BEHAVIORAL: Cognitive behavioral therapy (CBT)|BEHAVIORAL: computerized cognitive training (CCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: ElderTree Smart System for Older Adults
Status: COMPLETED
Conditions: Chronic Pain
Interventions: BEHAVIORAL: ElderTree on laptop (ET- LT)|BEHAVIORAL: ElderTree on smart system (ET- SS)|BEHAVIORAL: Treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Physical Therapy and Occupational Therapy After Transcatheter Aortic Valve Replacement
Status: COMPLETED
Conditions: Transcatheter Aortic Valve Implantation
Interventions: OTHER: Post procedure daily PT and OT|OTHER: PT post procedure|OTHER: OT post procedure|OTHER: Routine PT or OT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ectopic Adipose Tissue, Exercise Training and IL-6
Status: COMPLETED
Conditions: Adiposity
Interventions: BEHAVIORAL: Endurance Exercise Training|BEHAVIORAL: Resistance Exercise Training|BEHAVIORAL: No Exercise|DRUG: Tocilizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Short-term Memory Assessment in Patients With Poststroke Aphasia
Status: COMPLETED
Conditions: Aphasia, Acquired|Short-Term Memory Impairment
Interventions: DIAGNOSTIC_TEST: short term memory assessment|DIAGNOSTIC_TEST: Oxford cognitive screen|DIAGNOSTIC_TEST: Token Test|DIAGNOSTIC_TEST: Montreal cognitive assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Truenat™MTB Plus/COVID-19 Test for TB (Tuberculosis) and COVID-19 (SARS-CoV2)
Status: ACTIVE_NOT_RECRUITING
Conditions: TB|COVID-19
Interventions: DEVICE: Truenat™ MTB Plus/COVID-19
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Safety and Efficacy of CD38 Monoclonal Antibody Monotherapy for CaAMR in Renal Transplantation
Status: RECRUITING
Conditions: Antibody-mediated Rejection|Kidney Tranplant
Interventions: DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin ± Nivolumab in Combination With Trifluridine/Tipiracil or 5-fluorouracile in Frail Patients With Advanced, Recurrent or Metastatic Gastric, Oesophageal or Gastroesophageal Junction Cancer
Status: RECRUITING
Conditions: Gastric Adenocarcinoma|Esophagus Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Trifluridine/Tipiracil|DRUG: Oxaliplatin|DRUG: FOLFOX regimen|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Budesonide and Formoterol Absorption From Budesonide/Formoterol Easyhaler and Symbicort Turbuhaler
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Budesonide/formoterol Easyhaler 320/9 microg|DRUG: Symbicort Turbuhaler forte
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Tapering Low Dose Dexamethasone to Other Standard of Care Therapies for TAPS in Breast Cancer Patients
Status: COMPLETED
Conditions: Early-stage Breast Cancer|Pain Syndrome
Interventions: DRUG: Dexamethasone tapering dose|DRUG: Dexamethasone physician choice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Diagnostic Accuracy of Nuance Full-Field Digital Mammography to Screen-Film Mammography
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DEVICE: Full Field Digital Mammogram (Planmed Sophie Nuance)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cranial Electrotherapy Stimulation and Acute Stress
Status: RECRUITING
Conditions: Anxiety State
Interventions: DEVICE: Active CES|DEVICE: Sham CES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Dose Escalation Study of Glofitamab (RO7082859) as a Single Agent and in Combination With Obinutuzumab, Administered After a Fixed, Single Pre-Treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma
Status: RECRUITING
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Glofitamab|DRUG: Obinutuzumab|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study of MT-8554 in Subjects With Painful Diabetic Peripheral Neuropathy
Status: COMPLETED
Conditions: Painful Diabetic Peripheral Neuropathy
Interventions: DRUG: MT-8554|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: XIENCE PRIME Japan Post-Marketing Surveillance (PMS)
Status: COMPLETED
Conditions: Angina|Coronary Occlusion|Coronary Artery Disease|Coronary Artery Stenosis|Myocardial Ischemia
Interventions: DEVICE: XIENCE PRIME - Long Length (LL)|DEVICE: XIENCE PRIME - Core Size
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Egcg, a dyrk1a Inhibitor as Therapeutic Tool for Reversing Cognitive Deficits in Down Syndrome Individuals.
Status: COMPLETED
Conditions: Down Syndrome
Interventions: DIETARY_SUPPLEMENT: Epigallocatechin-3-gallate (EGCG)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 1stline Study Capecitabine Administered on Continuous Way Plus Oxaliplatin&Bevacizumab Every 2weeks in Metastatic CCR.
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Bevacizumab|DRUG: Capecitabine|DRUG: Oxaliplatine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Migraine--Investigational Treatment of Migraine With Noninvasive Brain Stimulation. (tDCS- Migraine)
Status: COMPLETED
Conditions: Migraine
Interventions: DEVICE: DC Stimulator (Transcranial Direct Current Stimulator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Cyclosporine Microemulsion and Tacrolimus on the Rate of New Onset Diabetes Mellitus in Kidney Transplantation Recipients
Status: COMPLETED
Conditions: Kidney Transplant
Interventions: DRUG: Cyclosporine microemulsion|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of HA Gel Injection Versus Multilayer (L-PRF) in the Interdental Papilla Reconstruction
Status: COMPLETED
Conditions: Gingival Papillary Cratering
Interventions: COMBINATION_PRODUCT: Hyaluronic acid gel|COMBINATION_PRODUCT: Multilayer L-PRF membranes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Gentamicin Intravesical Efficacy for Infection of Urinary Tract
Status: COMPLETED
Conditions: Postoperative Urinary Tract Infection|Pelvic Organ Prolapse|Stress Urinary Incontinence
Interventions: DRUG: gentamicin sulfate|OTHER: Catheter clamping only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Mechanisms of Sarcopenia in Chronic Inflammatory Disease: Protocol for a Prospective Cohort Study
Status: UNKNOWN
Conditions: Chronic Liver Disease|Rheumatoid Arthritis|Inflammatory Bowel Diseases
Interventions: OTHER: National Healthcare System Standard of care for each disease type (National Institute for Health and Care Excellence guidelines)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Natural History and Results of Dual Chamber (DDD) Pacemaker Therapy of Children With Obstructive Hypertrophic Cardiomyop...
Status: COMPLETED
Conditions: Hypertrophic Cardiomyopathy
Interventions: DEVICE: Paragon Pacemaker
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of the Safety of Therapeutic Tx With Immunomodulatory MSC in Adults With COVID-19 Infection Requiring Mechanical Ventilation
Status: TERMINATED
Conditions: COVID
Interventions: BIOLOGICAL: BM-Allo.MSC|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Product Performance of a Toric Contact Lens
Status: COMPLETED
Conditions: Myopia|Astigmatism
Interventions: DEVICE: SofLens DD Toric|DEVICE: Ciba Vision Focus Dailies Toric Contact Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Gut Microbiome and Colorectal Tumors
Status: COMPLETED
Conditions: Serrated Polyp|Hyperplastic Polyp|Sessile Serrated Adenoma|Colorectal Cancer
Interventions: DIAGNOSTIC_TEST: Mobio PowerSoil DNA Isolation Kit
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Carbon-14-Labelled [14C] LY3473329 in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: [14C]-LY3473329|DRUG: [14C]-LY3473329|DRUG: LY3473329
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dose Reduction of Etanercept in Patients With Ankylosing Spondylitis
Status: UNKNOWN
Conditions: Ankylosing Spondylitis
Interventions: DRUG: etanercept (Half-Dose)|DRUG: etanercept (Full-Dose)|DRUG: Sulfasalazine|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycopyrronium and Formoterol Fumarate (GFF) Metered Dose Inhaler (MDI) Dose Indicator Study in Adults With Moderate to Very Severe COPD
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Glycopyrronium and Formoterol Fumarate Metered-dose Inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of a Multimedia Information Site in Reducing Preoperative Anxiety in Vascular Surgery Patients.
Status: UNKNOWN
Conditions: Vascular Diseases
Interventions: OTHER: anxiety survey|OTHER: scale of satisfaction|OTHER: Multimedia Information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Youth Power Action Feasibility Study of Online Support Group Intervention Among Adolescents Living With HIV in Nigeria
Status: COMPLETED
Conditions: HIV/AIDS|Adolescent Behavior|Medication Adherence|Health Behavior
Interventions: BEHAVIORAL: Online support group
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Natural History Study of Patients With Neurofibromatosis Type I
Status: ACTIVE_NOT_RECRUITING
Conditions: Neurofibromatosis Type 1|Malignant Peripheral Nerve Sheath Tumor|Plexiform Neurofibroma|Optic Glioma|Neurofibroma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of a Single Vaccination With a 4-Antigen Staphylococcus Aureus Vaccine (SA4Ag) in Healthy Adults Aged 18 to <65 Years
Status: COMPLETED
Conditions: Staphylococcal Infections
Interventions: BIOLOGICAL: SA4Ag vaccine|PROCEDURE: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Formative Research Study to Address Protein Intake in Children and Analysis of Breast Milk Nutrient Content in Mothers
Status: COMPLETED
Conditions: Protein Malnutrition
Interventions: DIETARY_SUPPLEMENT: Egg Alone|DIETARY_SUPPLEMENT: Egg and ready to use supplementary food (RUSF)|DIETARY_SUPPLEMENT: Egg and breast milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Texts For Healthy Teens: A Health Education Program for Adolescents
Status: COMPLETED
Conditions: Food Habits
Interventions: BEHAVIORAL: 1: Tailored SMS program implicating friend and mother|BEHAVIORAL: 2: Standardized SMS program implicating friend and mother|BEHAVIORAL: 3: Tailored SMS program implicating friend, not mother|BEHAVIORAL: 4: Standardized SMS program implicating friend, not mother|BEHAVIORAL: 5: Tailored SMS program implicating mother, not friend|BEHAVIORAL: 6: Standardized SMS program implicating mother, not friend|BEHAVIORAL: 7: Tailored SMS program not implicating mother or friend|BEHAVIORAL: 8: Standardized SMS program not implicating mother or friend|BEHAVIORAL: 9: No SMS program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cardiovascular Safety Study of Magnevist® Injection at Two Dose Levels and Two Injection Rates in Normal Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Gadopentetate dimeglumine (Magnevist, BAY86-4882)|DRUG: Gadopentetate dimeglumine (Magnevist, BAY86-4882)|DRUG: Gadopentetate dimeglumine (Magnevist, BAY86-4882)|DRUG: Gadopentetate dimeglumine (Magnevist, BAY86-4882)|DRUG: Moxifloxacin (BAY12-8039)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Collection of Bone Marrow From Donors Treated With or Without Filgrastim
Status: COMPLETED
Conditions: Healthy Stem Cell Donor|No Evidence of Disease
Interventions: PROCEDURE: Bone Marrow Donation|BIOLOGICAL: Filgrastim|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Comparison of Proprioception and Gait Function Among Different Rotational Designs in Knee Arthroplasty
Status: ENROLLING_BY_INVITATION
Conditions: Arthroplasty, Replacement, Knee|Proprioception|Gait|Balance
Interventions: DEVICE: Knee arthroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Photographic Food Recognition and Meal Size Estimation Before and After Roux-en-Y Gastric Bypass
Status: COMPLETED
Conditions: Obesity, Morbid|Bariatric Surgery|Roux-en-Y Gastric Bypass|Food Preferences
Interventions: BEHAVIORAL: Recording of food intake.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nasal Versus Oronasal Mask in Continuous Positive Airway Pressure (CPAP) Treatment of Patients Affected by Obstructive Sleep Apnea Syndrome (OSAS).
Status: COMPLETED
Conditions: Osa Syndrome
Interventions: OTHER: patients shifted to nasal mask after persistent OSA with oronasal mask
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Advance Care Planning With Formerly Homeless Older Adults Residing in Permanent Supportive Housing
Status: RECRUITING
Conditions: Advance Care Planning
Interventions: BEHAVIORAL: Facilitated Group ACP Session|BEHAVIORAL: Facilitated one-on-one ACP visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TRAK vs Standard Home-based Exercise in Low Back Pain
Status: NOT_YET_RECRUITING
Conditions: Low Back Pain
Interventions: OTHER: Exercise supported by the digital physiotherapy and telerehabilitation software TRAK|OTHER: Standard home-based exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Corticosteroid Dosing Regimens After Endothelial Keratoplasty
Status: COMPLETED
Conditions: Fuchs' Dystrophy|Corneal Edema
Interventions: DRUG: loteprednol etabonate|DRUG: prednisolone acetate 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 1b/2a Unblinded Study of Responses in Premenopausal Women With HSDD to Lorexys Evaluating Efficacy and Safety
Status: COMPLETED
Conditions: Hypoactive Sexual Desire Disorder (DSM-IV-TR Defined)|Sexual Interest/Arousal Disorder (DSM-5 Defined)
Interventions: DRUG: bupropion, Lorexys low-dose, Lorexys moderate-dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Study
Status: NOT_YET_RECRUITING
Conditions: Chronic Subdural Hematoma
Interventions: PROCEDURE: Conventional Surgery|DEVICE: Middle Meningeal Artery Embolization (MMAE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety, Pharmacokinetics, and Antiviral Efficacy of SB 9200 in Subjects Infected With Chronic HBV
Status: COMPLETED
Conditions: Hepatitis B|Hepatitis, Viral
Interventions: DRUG: SB 9200|DRUG: Placebo|DRUG: Tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety, Tolerability, and Pharmacokinetics of GDC-0425 Administered With and Without Gemcitabine in Patients With Refractory Solid Tumors or Lymphoma
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: GDC-0425|DRUG: gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Two Brands of Heparin Already on the Market
Status: COMPLETED
Conditions: Coronary Artery Bypass Grafting
Interventions: DRUG: Heparin Leo and Hepalean
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Sodium Bicarbonate Ringer's Solution for Preventing and Treating Hyperlactacidemia During Hepatectomy
Status: UNKNOWN
Conditions: Hyperlactacidemia
Interventions: DRUG: Sodium Bicarbonate Ringer's Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Neratinib +Trastuzumab or Neratinib + Cetuximab in Patients With KRAS/NRAS/BRAF/PIK3CA Wild-Type Metastatic Colorectal Cancer by HER2 Status
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Trastuzumab|DRUG: Cetuximab|DRUG: Neratinib|DIAGNOSTIC_TEST: Guardant360 Diagnostic Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability, PK, and PD Study of Single and Multiple ALXN2080 Doses in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ALXN2080|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cingal Study for Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Hyaluronic Acid and TH (Cingal®)|DEVICE: Hyaluronic Acid (Monovisc®)|DEVICE: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Lonigutamab in Subjects With Thyroid Eye Disease (TED)
Status: RECRUITING
Conditions: Thyroid Eye Disease
Interventions: DRUG: lonigutamab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Spinal Manual Therapy Interventions for a Future Clinical Study of Back Pain
Status: COMPLETED
Conditions: Back Pain|Back Pain With Radiation|Back Pain, Low
Interventions: PROCEDURE: Active spinal manual therapy protocol|PROCEDURE: Control spinal manual therapy protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Controlled Evaluation of a Computerized Anger-reduction Treatment for Suicide Prevention
Status: COMPLETED
Conditions: Anger|Suicidal Ideation
Interventions: BEHAVIORAL: Anger Reduction Treatment|BEHAVIORAL: Progressive Muscle Relaxation|BEHAVIORAL: Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomised Placebo-controlled Study of FMT to Impact Body Weight and Glycemic Control in Obese Subjects With T2DM
Status: COMPLETED
Conditions: Type2 Diabetes|Type 2 Diabetes Mellitus|Obese
Interventions: PROCEDURE: Fecal Microbiota Transplantation|BEHAVIORAL: Lifestyle Modification Program|PROCEDURE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sintilimab (IBI308) in the Neoadjuvant Treatment of Patients With Resectable II-IIIA NSCLC
Status: UNKNOWN
Conditions: Lung Diseases|Neoplasms|Respiratory Tract Diseases|Thoracic Neoplasms|Non-small-cell Lung Cancer
Interventions: DRUG: Sintilimab injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Surgical Treatment by Different Pedicle Screw Systems in Pediatric Neuromuscular Spinal Deformity
Status: COMPLETED
Conditions: Neuromuscular Diseases|Neuromuscular Scoliosis
Interventions: PROCEDURE: Scoliosis surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Darolutamide With Radium-223 or Placebo and the Effect on Radiological Progression-Free Survival for Patients With mCSPC
Status: WITHDRAWN
Conditions: Metastatic Prostate Cancer
Interventions: DRUG: Darolutamide|DRUG: Radium-223
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Sirolimus Therapy for Segmental Overgrowth Caused by Somatic PI3K Activation
Status: COMPLETED
Conditions: PIK3CA-Related Overgrowth Spectrum (PROS)|Growth Disorder|Genetics
Interventions: DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retention With Three Different Bonded Retainers a Multicenter, Randomized Controlled Trial With 5-year Follow-up
Status: RECRUITING
Conditions: Dental Malocclusion|Stability
Interventions: OTHER: Orthodontic retention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetics, Safety and Efficacy Study of Tafenoquine (TQ) in Pediatric Subjects With Plasmodium Vivax (P. Vivax) Malaria
Status: COMPLETED
Conditions: Malaria, Vivax
Interventions: DRUG: Tafenoquine|DRUG: Chloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet Rich Plasma Injection Compared With Steroid Injection for the Treatment of Plantar Fasciitis
Status: COMPLETED
Conditions: Plantar Fasciitis|Steroid|Platelet-rich Plasma (PRP)
Interventions: DRUG: Platelet Rich Plasma (PRP) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Bioavailability and Effect on Pouch pH of Esomeprazole After Gastric Bypass
Status: RECRUITING
Conditions: Obesity|Gastric Reflux|Ulcer, Gastric
Interventions: DIAGNOSTIC_TEST: upper endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Multi-elemental Imaging of Lung Tissues With LIBS (Laser-induced Breakdown Spectroscopy)
Status: COMPLETED
Conditions: Interstitial Lung Disease|Sarcoidosis|Idiopathic Pulmonary Fibrosis
Interventions: DIAGNOSTIC_TEST: Elemental analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of Pituitary Adenylate Cyclase Activating Polypeptide-Brain Derived Neurotrophic Factor (PACAP-BDNF) Signaling System Involvement in Etiology and Treatment of Major Depression
Status: COMPLETED
Conditions: Major Depression
Interventions: DRUG: SSRI; SNRI; TCA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Escitalopram for Prevention of Depression Induced by Peg-Interferon in Hepatitis C Patients
Status: COMPLETED
Conditions: Major Depressive Disorder|Hepatitis C, Chronic
Interventions: DRUG: Escitalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Examining the Effect of Different Diuretics on Fluid Retention in Diabetics Treated With Rosiglitazone.
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Rosiglitazone|DRUG: spironolactone|DRUG: hydrochlorothiazide|DRUG: frusemide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of SHR-1210 in Combination With Carboplatin + Paclitaxel in Subjects With Squamous NSCLC
Status: UNKNOWN
Conditions: Lung Cancer Squamous Cell|Lung Cancer Stage IV|PD-1 Antibody|Chemotherapy Effect
Interventions: DRUG: SHR-1210|DRUG: The placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Tear Film Thickness by Optical Coherence Tomography in Healthy Subjects and Subjects With Dry Eye Disease
Status: WITHDRAWN
Conditions: Dry Eye Syndrome
Interventions: DEVICE: GENTEAL HA® Eye Drops (NOVARTIS, Switzerland)|OTHER: Physiological Sodium Chloride solution (0,9%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Exercise-based Telerehabilitation Program for Police Officers and Firefighters With Chronic Non-specific Low Back Pain
Status: COMPLETED
Conditions: Chronic Low-back Pain|Telerehabilitation
Interventions: OTHER: App-Based Pain Education and Exercise|OTHER: Online booklet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anal Human Papillomavirus in Inflammatory Bowel Disease Study
Status: COMPLETED
Conditions: Inflammatory Bowel Disease (IBD)|Ulcerative Colitis (UC)|Crohn's Disease (CD)|Anal Human Papillomavirus
Interventions: PROCEDURE: Venous blood samples, anal swab samples, vaginal swab samples, high resolution anoscopy (HRA), anal biopsy samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: NOURISH-T+: Promoting Healthy Eating and Exercise Behaviors
Status: RECRUITING
Conditions: Obesity, Childhood|Cancer|Survivorship
Interventions: BEHAVIORAL: NOURISH-T+|BEHAVIORAL: Brief NOURISH-T+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Trial of Telenursing for Monitoring Supportive Care Needs in Patients With Lung Cancer and Melanoma Candidates for the First Prescription of Targeted Therapies
Status: RECRUITING
Conditions: Lung Neoplasm|Melanoma
Interventions: PROCEDURE: Telenursing interventions for monitoring Supportive Care Needs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preemptive Infiltration With Betamethasone and Ropivacaine for Postoperative Pain in Laminoplasty or Laminectomy
Status: COMPLETED
Conditions: Pain, Postoperative|Neurosurgery
Interventions: DRUG: The Treatment group|DRUG: The Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Enhanced Hood PPE to Minimize COVID-19 Transmission to Front-line Health Care Workers
Status: UNKNOWN
Conditions: Covid19
Interventions: DEVICE: current IPAC-UHN PPE|DEVICE: modified IPAC-UHN PPE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Citrus Beverages and Gastrointestinal Function
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: 0 g pomace (control)|DIETARY_SUPPLEMENT: 90 g pomace|DIETARY_SUPPLEMENT: 180 g pomace|DIETARY_SUPPLEMENT: Flavored water (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Resin Infiltration of Proximal Caries
Status: UNKNOWN
Conditions: Caries; Initial
Interventions: OTHER: resin infiltration|OTHER: remineralization|OTHER: sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Yellow Fever Vaccine Administered With Tetravalent Dengue Vaccine in Healthy Toddlers
Status: COMPLETED
Conditions: Dengue|Dengue Hemorrhagic Fever|Yellow Fever
Interventions: BIOLOGICAL: Live, attenuated dengue serotype 1, 2, 3, and 4 virus|BIOLOGICAL: Yellow fever vaccine|BIOLOGICAL: Measles, mumps, and rubella (MMR) vaccine|BIOLOGICAL: Pneumococcal Conjugated Vaccine|BIOLOGICAL: Hepatitis A Pediatric Vaccine|BIOLOGICAL: Diphtheria, tetanus, pertussis, polio, and Haemophilus influenzae vaccine|BIOLOGICAL: Live, attenuated dengue serotype 1, 2, 3, and 4 virus|BIOLOGICAL: Yellow Fever Vaccine|BIOLOGICAL: Placebo (NaCl)|BIOLOGICAL: Measles, mumps, and rubella vaccine|BIOLOGICAL: Pneumococcal Conjugated Vaccine|BIOLOGICAL: Diphtheria, tetanus, pertussis, polio, and Haemophilus influenzae vaccine|BIOLOGICAL: Hepatitis A Pediatric Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Fecal Microbiota Transplantation in Patients With Rheumatoid Arthritis Refractory to Methotrexate
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: PROCEDURE: FMT+MTX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Sacituzumab Govitecan (SG) in Japanese Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Metastatic Triple-Negative Breast Cancer|HR+/HER2- Metastatic Breast Cancer|Metastatic Urothelial Cancer
Interventions: DRUG: Sacituzumab Govitecan-hziy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the CDX-1307 Vaccine Regimen in Patients With Newly Diagnosed Muscle-Invasive Bladder Cancer (The "N-ABLE" Study)
Status: TERMINATED
Conditions: Bladder Cancer
Interventions: BIOLOGICAL: CDX-1307 Vaccine Regimen|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer
Status: TERMINATED
Conditions: Mucinous Adenocarcinoma of the Colon|Mucinous Adenocarcinoma of the Rectum|Recurrent Colon Cancer|Recurrent Rectal Cancer|Signet Ring Adenocarcinoma of the Colon|Signet Ring Adenocarcinoma of the Rectum|Stage IVA Colon Cancer|Stage IVA Rectal Cancer|Stage IVB Colon Cancer|Stage IVB Rectal Cancer
Interventions: DRUG: fluorouracil|DRUG: sodium phenylbutyrate|DRUG: indomethacin|BIOLOGICAL: recombinant interferon gamma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rivaroxaban Utilization for Treatment and Prevention of Thromboembolism in Cancer Patients: Experience at a Comprehensive Cancer Center
Status: COMPLETED
Conditions: Cancer|Deep-vein Thrombosis of the Lower and Upper Extremities|Pulmonary Embolism|Non-valvular Atrial Fibrillation
Interventions: OTHER: Retrospective Chart Review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Early Versus Delayed Cord Clamping at Term: Outcomes in Swedish Infants
Status: COMPLETED
Conditions: Iron Deficiency|Neonatal Hyperbilirubinemia
Interventions: PROCEDURE: Timing of clamping the umbilical cord
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Virtual Reality Use for Peri-Procedural Analgesia and Anxiolysis
Status: UNKNOWN
Conditions: Acute Pain
Interventions: DEVICE: Virtual Reality use during painful bedside procedure|DRUG: Standard Treatment during painful bedside procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Narcotic Free TIVA and Incidence of Unacceptable Movements Under Anesthesia During ACDF Surgery
Status: COMPLETED
Conditions: Anterior Cervical Discectomy and Fusion (ACDF)
Interventions: DRUG: Remifentanil|DRUG: Ketamine|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Parent Involvement in Adolescent Obesity Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Pediatric Obesity
Interventions: BEHAVIORAL: TEENS+Parents as Coaches|BEHAVIORAL: TEENS+Parent Weight Loss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT