pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Radio Frequency Ablation in the Management of Pancreatico-biliary Disorders: A Multicenter Registry
Status: UNKNOWN
Conditions: Cholangiocarcinoma|Pancreatic Cancer|Bile Duct Cancer|Biliary Stricture|Bile Duct Obstruction
Interventions: DEVICE: Radio Frequency ablation Probe
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical and Laboratory Study of Lysozyme Deposition on Daily Disposable Contact Lenses
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: etafilcon A|DEVICE: nelfilcon A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Exploratory Study of PENNSAID Gel to Treat Symptoms of Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: PENNSAID Gel|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Obesity and Bariatric Surgery According to a Biopsychosocial Perspective.
Status: RECRUITING
Conditions: Obesity|Heart Rate Variability|Anxiety Disorders|Depression|Quality of Life
Interventions: DEVICE: Holter Faros 360° EKG (Bittium Corporation)|DIAGNOSTIC_TEST: Beck Depression Inventory (BDI)|DIAGNOSTIC_TEST: Hospital Anxiety and Depression Scales - HADS|DIAGNOSTIC_TEST: Three Factor Eating Questionnaire-R21 - TFEQ-R21|DIAGNOSTIC_TEST: hort-Form Health Survey-36 itens - SF-36
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room
Status: COMPLETED
Conditions: Status Asthmaticus
Interventions: DRUG: Budesonide|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postpartum Urinary Retention With Essential Oils (PURE)
Status: ENROLLING_BY_INVITATION
Conditions: Urinary Retention
Interventions: OTHER: Peppermint Oil Vapor|OTHER: Mineral Oil Vapor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Nitazoxanide 600 mg to Treat Mild Ambulatory COVID-19 Patients
Status: WITHDRAWN
Conditions: covid19
Interventions: DRUG: Nitazoxanide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nutritional Interventions on Inflammatory Status in Healthy Overweight Men
Status: COMPLETED
Conditions: Overweight|Diabetes|Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Plain Yogurt + mix of anti-oxidants capsules|DIETARY_SUPPLEMENT: Yogurt containing Lactobacillus helveticus|DIETARY_SUPPLEMENT: Yogurt containing Bifidobacterium animalis ssp.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Wound Edge Changes Following Treatment With Santyl
Status: COMPLETED
Conditions: Diabetic Foot Ulcers|Diabetic Foot Wounds
Interventions: BIOLOGICAL: Collagenase Santyl Ointment|OTHER: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy of XPro1595 in Patients With Mild Cognitive Impairment With Biomarkers of Inflammation
Status: WITHDRAWN
Conditions: Mild Cognitive Impairment (MCI)|Alzheimer Disease|Dementia|Brain Diseases|Central Nervous System Diseases|Nervous System Diseases|Tauopathies|Neurodegenerative Diseases|Mental Disorders
Interventions: DRUG: XPro1595|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Home-Based Exercise Manual on Pain and Disability in Patients of Postural Neck Pain
Status: COMPLETED
Conditions: Postural Neck Pain
Interventions: OTHER: Home-based Exercise Manual|OTHER: Conventional PT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antidiabetic Effects of Adding a DPP-4 Inhibitor to Pre-Existing Treatment With an Incretin Mimetic in Patients With T2D
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Placebo|OTHER: Mixed meal test|DRUG: Liraglutide|DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nasopharyngeal Airway Facilitate Transnasal Humidified Rapid Insufflation Ventilatory Exchange
Status: UNKNOWN
Conditions: Hypoxia|Hypercapnia
Interventions: DEVICE: Nasopharyngeal airway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cadonilimab in Combination With Anlotinib in the Treatment of Locally Progressive or Metastatic Melanoma With First-Line Therapy Failure
Status: NOT_YET_RECRUITING
Conditions: Melanoma
Interventions: DRUG: Cadonilimab|DRUG: anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Dynamic Ultrasonography Replace Urodynamics in Follow-up of Patients With Myelomeningocele
Status: COMPLETED
Conditions: Neurogenic Bladder|Myelomeningocele
Interventions: DIAGNOSTIC_TEST: Dynamic Ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: Trident Multi-tined Cannula for Cervical MBRFA Compared to the Conventional Cannula
Status: RECRUITING
Conditions: Cervical Pain|Cervical Facet Joint Pain
Interventions: PROCEDURE: Cervical Medial Branch Radiofrequency Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Ongoing Beta-blockers Administration on Analgesic Requirements in the Immediate Perioperative Period.
Status: UNKNOWN
Conditions: Nociceptive Pain
Interventions: OTHER: Chronic use of Beta adrenergic receptor blocker
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Long-term Neurodevelopment in Neonatal Encephalopathy by Infant Treadmill
Status: WITHDRAWN
Conditions: Hypoxic-Ischemic Encephalopathy|Periventricular Leukomalacia|Intraventricular Hemorrhage|Bilirubin Encephalopathy|Kernicterus|Hypoglycemia, Neonatal|Cerebral Infarction
Interventions: DEVICE: Baby treadmill|BEHAVIORAL: Physical rehabilitation training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Abrogation of Chronic Monoclonal Antibody Treatment-induced T-cell Exhaustion With DURVALUMAB in Advanced HER-2 Negative Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer|Bevacizumab-alone Maintenance Treatment Progression
Interventions: DRUG: Durvalumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Evaluation of Novel Glucose Sensing Technology on Hypoglycaemia in Type 1 Diabetes (IMPACT)
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: Sensor Based Glucose Monitoring System|DEVICE: Standard Blood Glucose Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Tolerance Trial of Cinobufacini Injection Intraperitoneal Perfusion on Digestive System Cancer With Ascites
Status: UNKNOWN
Conditions: Digestive System Cancer|Malignant Ascites
Interventions: DRUG: Cinobufacini Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Two Surgical Approaches for Total Hip Arthroplasty
Status: COMPLETED
Conditions: Total Hip Arthroplasty
Interventions: PROCEDURE: Minimally Invasive Total Hip Arthroplasty|PROCEDURE: Conventional Total Hip Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Tertulias Social Isolation Women's Groups Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Social Isolation|Depression
Interventions: BEHAVIORAL: TERTULIAS structured dialogue peer support groups|BEHAVIORAL: Modified Attention Placebo Control (MAPC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors
Status: RECRUITING
Conditions: Endometrial Cancer|Cervical Cancer|Ovarian Cancer|Urothelial Carcinoma|Biliary Tract Cancer|Breast Cancer|Lung Cancer|Gastric Cancer|Gastroesophageal-junction Cancer|Esophageal Cancer
Interventions: DRUG: BL-M07D1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trametinib and Akt Inhibitor GSK2141795 in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Trametinib|DRUG: Uprosertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of TB006 in Participants With Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: TB006|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using the Anticancer Drug Olaparib to Treat Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome With an Isocitrate Dehydrogenase (IDH) Mutation
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Acute Myeloid Leukemia Post Cytotoxic Therapy|Recurrent Acute Myeloid Leukemia|Recurrent Myelodysplastic Syndrome|Refractory Acute Myeloid Leukemia|Refractory Myelodysplastic Syndrome
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Injectable Plasma Versus the Use of Simvastatin Gel in Surgical Management of Bony Defect in Dentistry
Status: UNKNOWN
Conditions: Intra-bony Pockets
Interventions: DRUG: Simvastatin|OTHER: injectable plasma rich fibrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microvascular Function in Patients Undergoing 5-Fluorouracil Chemotherapy
Status: UNKNOWN
Conditions: Gastrointestinal Cancer|Head and Neck Cancer|Breast Cancer|Chemotherapy Effect|5-Fluorouracil Toxicity
Interventions: OTHER: Arterial blood pressure|OTHER: Skin microcirculatory blood flow|OTHER: Brachial artery blood flow|OTHER: Venous blood draw
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CORRECTION OF EAR DEFORMITIES IN NEWBORNS BY MODELING, COMPARISON OF TWO PROTOCOLS
Status: RECRUITING
Conditions: Ear Malformation
Interventions: DEVICE: Custom-made silicone device|DEVICE: adjustable Earwell device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Intrauterine Cornual Block in Combination With Direct Cervical Block in Outpatient Endometrial Ablation
Status: COMPLETED
Conditions: Endometrial Diseases
Interventions: PROCEDURE: Local Anaesthetic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: [18F]THK-5351 Positron Emission Computed Tomography Study of Normal, Mild Cognitive Impairment, Alzheimer's Disease and Other Neurodegenerative Disease
Status: COMPLETED
Conditions: Alzheimer's Disease|Mild Cognitive Impairment|Neurodegenerative Diseases
Interventions: DRUG: [18F]THK-5351
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Efficacy and Safety of Apatinib Monotherapy in Maintenance Treatment of Extensive-stage Small-cell Lung Cancer
Status: UNKNOWN
Conditions: Apatinib in Maintenance Treatment
Interventions: DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain After Preoperative UltraSound Guided Hip Injections for Total Hip Arthroplasty (PUSH)
Status: COMPLETED
Conditions: Total Hip Replacement|Arthroplasty
Interventions: PROCEDURE: Butterfly IQ|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Evaluate the Safety and Efficacy of Abatacept in Adults and Children 6 Years and Older With Excessive Loss of Protein in the Urine Due to Either Focal Segmental Glomerulosclerosis (FSGS) or Minimal Change Disease (MCD)
Status: COMPLETED
Conditions: Nephrotic Syndrome|Focal Segmental Glomerulosclerosis|Minimal Change Disease
Interventions: DRUG: Abatacept|OTHER: Normal Saline|OTHER: D5W
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alternative 10 mg/mL Liquid Formulation of ACY 1215 (Ricolinostat) in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ACY-1215
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Two Intrauterine Devices (IUDs) Among Cape Town HIV-positive Women
Status: COMPLETED
Conditions: HIV
Interventions: DEVICE: Mirena levonorgestrel IUD|DEVICE: Copper T-380a IUD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Heart Rate Variability During Auricular Acupressure at Zero Point on the Left Ear in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: PROCEDURE: Auricular acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Drug-Drug Interaction of DWP16001 in Combination With DWC202204 and DWC202205 in Healthy Male Adults
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: DWP16001|DRUG: DWC202204+DWC202205|DRUG: DWP16001+DWC202204+DWC202205
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Washed Versus Standard Blood Cell Transfusions in Pediatric Open Heart Surgery
Status: COMPLETED
Conditions: Congenital Heart Disease
Interventions: BIOLOGICAL: Standard leukoreduced irradiated blood cell transfusion|BIOLOGICAL: Washed leukoreduced irradiated blood cell transfusions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study for Subjects With COVID-19 Using Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells
Status: NOT_YET_RECRUITING
Conditions: Corona Virus Infection|Covid19
Interventions: BIOLOGICAL: Allogeneic adipose-derived stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform
Status: TERMINATED
Conditions: Central Retinal Artery Occlusion
Interventions: DEVICE: Transcorneal electric stimulation|DEVICE: Transcorneal stimulation|DEVICE: transcorneal electric stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Follow-up of Gene Therapy for Radiation-Induced Xerostomia
Status: ENROLLING_BY_INVITATION
Conditions: Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands
Interventions: GENETIC: AAV2-hAQP1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification and Validation of Noninvasive Biomarkers of the Diagnosis and Severity of NASH in Type 2 Diabetics
Status: COMPLETED
Conditions: Type2 Diabetes
Interventions: DEVICE: new quantitative imaging techniques with contast products|DIAGNOSTIC_TEST: blood sample|DIAGNOSTIC_TEST: second generation tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Bipolar Androgen-based Therapy for Prostate Cancer (BAT)
Status: COMPLETED
Conditions: Recurrent Prostate Cancer
Interventions: DRUG: Testosterone cypionate|DRUG: Goserelin|DRUG: Leuprolide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study on Stopping Anticoagulation Medication in Patients With a History of Atrial Fibrillation
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: OTHER: Drug (Direct thrombin or Factor Xa inhibitor)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of the Avulux® Lenses as an Aid in Reducing the Impact of Migraine Headaches
Status: COMPLETED
Conditions: Migraine
Interventions: OTHER: 11-point pain scale|OTHER: Headache diary|DEVICE: Avulux®|DEVICE: Sham Avulux®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of Eplerenone on Heart Function in Women Receiving Anthracycline Chemotherapy for Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Eplerenone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Group Psychological Interventions on Extracellular Vesicles in People Who Had Cancer
Status: UNKNOWN
Conditions: Cancer
Interventions: BEHAVIORAL: Mindfulness Based-Cognitive Therapy (MBCT)|BEHAVIORAL: Emotion Focused Therapy Group for Cancer Recovery (EFT-CR)|OTHER: Treatment as usual (no intervention)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Polatuzumab Vedotin, Rituximab and Dose Attenuated CHP in Older Patients With DLBCL
Status: RECRUITING
Conditions: DLBCL|Lymphoma, B-Cell
Interventions: DRUG: Polatuzumab vedotin|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare Actions in Healthy Volunteer of 50 mg Etanercept Injection Using an Auto-injector Device and Manual Injection
Status: COMPLETED
Conditions: Healthy Men and Women
Interventions: DEVICE: Auto-injector device|OTHER: Etanercept (ENBREL®) via Manual injection|DRUG: Etanercept (ENBREL®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observation Study of Clinical Manifestation and Outcome in Chinese Patients With Pulmonary Vasculitis
Status: UNKNOWN
Conditions: ANCA-associated Vasculitis|Granulomatosis With Polyangiitis|Microscopic Polyangiitis|EosinphilicGranulomatosis With Polyangiitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: High-Fidelity Patient Simulation on Clinical Reasoning Skills and Interprofessional Competencies
Status: RECRUITING
Conditions: Healthy
Interventions: OTHER: Interprofessional Simulation Experience
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Focused Cardiac and Lung Ultrasound in Anesthesia/Critical Care - The Role of Self-directed Simulation-assisted Training Compared to a Traditional Supervised Approach
Status: UNKNOWN
Conditions: Education, Medical|Critical Care Ultrasonography
Interventions: OTHER: Self-directed and simulation-assisted training|OTHER: Traditional apprenticeship training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Procedural Sedation Using Propofol Versus Midazolam/Ketamine in the Adult Emergency Department
Status: COMPLETED
Conditions: Procedural Sedation
Interventions: DRUG: Ketamine/Midazolam|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Stevia Rebaudiana Bertoni on Levels of GCF Glucose and Bio-markers in Diabetics.
Status: UNKNOWN
Conditions: Periodontitis
Interventions: DRUG: stevia rebaudiana bertoni|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Saizen in Intra-uterine Growth Retardation
Status: COMPLETED
Conditions: Children Born With Serious Intra-uterine Growth Retardation
Interventions: DRUG: Saizen® A|DRUG: Saizen® B|OTHER: Observation only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multisite Feasibility of Compassion Meditation for Veterans With Posttraumatic Stress Disorder (PTSD)
Status: RECRUITING
Conditions: Posttraumatic Stress Disorder
Interventions: OTHER: Compassion meditation|BEHAVIORAL: Applied relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Immune Response to a Respiratory Syncytial Virus (RSV) Vaccine in Adults, RSV-Seropositive Children, and RSV-Seronegative Infants and Children
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: RSV MEDI ΔM2-2 vaccine|BIOLOGICAL: Placebo vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Abatacept Post-marketing Clinical Study in Japan
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Abatacept|DRUG: Placebo matching with Abatacept|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of JNJ26489112 in Patients With Treatment-Resistant Major Depressive Disorder
Status: TERMINATED
Conditions: Depression
Interventions: DRUG: Venlafaxine XR|DRUG: Placebo|DRUG: JNJ26489112
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 3 Ultrasound Guided Plane Blocks for Perioperative Analgesia in Patients Undergoing Radical Cystectomy
Status: COMPLETED
Conditions: Cancer, Bladder|Surgery|Anesthesia|Analgesia|Block
Interventions: PROCEDURE: Erector Spinae Plane Block|PROCEDURE: Thoracic Paravertebral Plane Block|PROCEDURE: Quadratus Lumborum Plane Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety Study on Menatetrenone in the Treatment of Postmenopausal Osteoporosis Women
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis
Interventions: DRUG: menatetranone|DRUG: alfacalcidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Getting To Implementation: Improving Cancer Screening for Veterans
Status: ENROLLING_BY_INVITATION
Conditions: Cancer of Liver|Cancer of Colon|Cirrhosis
Interventions: BEHAVIORAL: Patient Navigation|BEHAVIORAL: Implementation Facilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Sodium Heparin in Patients (Cristália)
Status: COMPLETED
Conditions: Cardiac Surgery
Interventions: BIOLOGICAL: heparin sodium - Cristália|BIOLOGICAL: Heparin sodium APP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: PROVOCATION Trial - PROphylactic intraVenOus Hydration for Contrast Agent Toxicity PreventION
Status: COMPLETED
Conditions: Kidney Failure, Acute
Interventions: DRUG: NaCl 0.9% i.v. or NaBic 1.4% i.v. or NaBic 1.4% i.v. + NaBic p.o. (Nephrotrans®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Reldesemtiv|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Melanoma Vaccine in Treating Patients With Stage III Melanoma After Surgery to Remove Lymph Nodes
Status: UNKNOWN
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: HLA-A1-binding MAGE-1/MAGE-3 multipeptide-pulsed autologous dendritic cell vaccine|BIOLOGICAL: HLA-A2-binding TYR/MART-1/gp100 multipeptide-pulsed autologous dendritic cell vaccine|BIOLOGICAL: autologous melanoma lysate-pulsed autologous dendritic cell vaccine|BIOLOGICAL: autologous melanoma lysate/KLH-pulsed autologous dendritic cell vaccine|BIOLOGICAL: dendritic cell-idiotype-keyhole limpet hemocyanin vaccine|OTHER: flow cytometry|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Response of 28 Days of Dosing of GSK962040 in Type I and II Diabetic Male and Female Subjects With Gastroparesis
Status: COMPLETED
Conditions: Gastroparesis
Interventions: DRUG: GSK962040 (5 mg tablet)|DRUG: GSK962040 (25 mg tablet)|DRUG: GSK962040 (125 mg tablet)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Safety, Pharmacokinetic and Efficacy of APG-5918 in Advanced Solid Tumors or Lymphomas
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma|Castrate Resistant Prostate Cancer|Gastric Cancer|Ovarian Clear Cell Carcinoma|Mesothelioma|Sarcoma|Non Hodgkin Lymphoma|B Cell Lymphoma|Epithelioid Sarcoma
Interventions: DRUG: APG-5918
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real World Evaluation of the Effectiveness of AZD7442 for Prevention of SARS-CoV-2
Status: TERMINATED
Conditions: SARS-CoV-2 Infection
Interventions: DRUG: Evusheld (tixagevimab+cilgavimab) IM or IV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Tislelizumab Combined With Lenvatinib and GEMOX Versus Tislelizumab Combined With GEMOX in Conversion Therapy of ICC and GBC.
Status: RECRUITING
Conditions: Potentially Resectable Locally Advanced Intrahepatic Cholangiocarcinoma and Gallbladder Cancer
Interventions: DRUG: tislelizumab+lenvatinib+GMOX|DRUG: tislelizumab+GEMOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of a Creative Writing Intervention in an Advanced Cancer Population: A Single Arm, Consecutive Cohort Study
Status: COMPLETED
Conditions: Primary Malignant Neoplasm of Lung|Primary Malignant Neoplasm of Gastrointestinal Tract
Interventions: OTHER: First Session|OTHER: Second Session|BEHAVIORAL: Third through Sixth Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: AMG 102 and Avastin for Recurrent Malignant Glioma
Status: COMPLETED
Conditions: Glioblastoma Multiforme|Gliosarcoma
Interventions: DRUG: AMG 102|DRUG: Avastin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Investigating the Pharmacodynamic and Pharmacokinetic Properties of Insulin Degludec/Insulin Aspart 15 in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin degludec/insulin aspart 15|DRUG: insulin degludec/insulin aspart|DRUG: insulin degludec|DRUG: insulin aspart|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nintedanib Plus Docetaxel in Japanese Patients With Adenocarcinoma Subtype Non-small Cell Lung Cancer After Failure of First Line Chemotherapy
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Nintedanib|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reversible Effect of Falling Ventilatory Drive in Drive-dependent OSA
Status: RECRUITING
Conditions: OSA
Interventions: OTHER: Dynamic CO2|OTHER: Sham CO2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Two Treatments That Both Target Smoking Cessation and Weight Loss at the Same Time.
Status: WITHDRAWN
Conditions: Smoking Cessation|Weight Loss
Interventions: BEHAVIORAL: Distress Tolerance|DRUG: transdermal nicotine patch|BEHAVIORAL: Active Health Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Biventricular Versus Right Ventricular Pacing in Heart Failure Patients With Atrioventricular Block (BLOCK HF)
Status: COMPLETED
Conditions: Atrioventricular Block|Heart Diseases
Interventions: DEVICE: Cardiac Resynchronization Therapy (CRT)|DEVICE: Cardiac Resynchronization Therapy (CRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Roflumilast in Improving Mucociliary Clearance in Patients With COPD and Chronic Bronchitis
Status: COMPLETED
Conditions: COPD|Chronic Bronchitis|Emphysema
Interventions: DRUG: Roflumilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CAPEcitabine eXtension of Adjuvant Therapy for Pancreatic Adenocarcinoma: (CAPE-X)
Status: WITHDRAWN
Conditions: Pancreas Cancer|Pancreas Adenocarcinoma
Interventions: DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Thermic Effects of Some Scottish Plant Foods
Status: COMPLETED
Conditions: Diet Induced Thermogenesis|Obesity Control
Interventions: DIETARY_SUPPLEMENT: Control Meal|DIETARY_SUPPLEMENT: Berry Treatment|DIETARY_SUPPLEMENT: Sea Buckthorn Treatment|DIETARY_SUPPLEMENT: Wild Garlic Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: HIV Prevention Among Latino MSM: Evaluation of a Locally Developed Intervention
Status: COMPLETED
Conditions: Risk Reduction Behavior
Interventions: BEHAVIORAL: HOLA en Grupos|BEHAVIORAL: General Health intervention (comparison intervention )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SurveY Followed by a Retrospective Chart Review to Describe the Key Factors Leading to Physician's Decision to Treat Patients at High and Very High Cardiovascular Risk With hyperchOlesterolemia or Mixed Dyslipidemia With NUSTENDI®
Status: COMPLETED
Conditions: Hypercholesterolemia|Mixed Dyslipidemia
Interventions: DRUG: Bempedoic Acid 180Mg/Ezetimibe 10Mg Tab|OTHER: No study drug
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Is There a Metabolic Effect of Cinnamon on HbA1c, Blood Pressure and Serum Lipids in Type 2 Diabetes Mellitus?
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: cinnamon 2g per day for 12 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SOLUTION: Study of Oral Liprotamase Unit-Matched Therapy Of Non-Porcine Origin in Patients With Cystic Fibrosis
Status: COMPLETED
Conditions: Exocrine Pancreatic Insufficiency|Cystic Fibrosis
Interventions: DRUG: Liprotamase|DRUG: porcine (pig) PERT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Lymphoseek® as a Lymphoid Tissue Targeting Agent in Pediatric Patients With Melanoma, Rhabdomyosarcoma, or Other Solid Tumors Who Are Undergoing Lymph Node Mapping
Status: COMPLETED
Conditions: Rhabdomyosarcoma|Melanoma
Interventions: DRUG: Tc99m tilmanocept|DRUG: Vital Blue Dye (optional)|PROCEDURE: Lymph Node Mapping
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Using mHealth to Improve Emotional Recovery After Pediatric Injury
Status: RECRUITING
Conditions: Trauma Injury|Child, Only|Posttraumatic Stress Disorder|Parents
Interventions: BEHAVIORAL: Caregivers' Aid to Accelerate Recovery after pediatric Emergencies (CAARE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inflammation Markers in Fluid Aspirate From a Scarred Uterine vs. a Normal Uterine Cavity
Status: RECRUITING
Conditions: Infertility Due to Nonimplantation|Infertility Secondary|Cesarean Section Complications
Interventions: DIAGNOSTIC_TEST: Uterine lavage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sintilimab Plus NCT or NCRT Versus NCRT for ESCC
Status: NOT_YET_RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Sintilimab|RADIATION: radiotherapy|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Respiratory Muscle Training in Malnourished Patients Undergoing Abdominal Surgery
Status: COMPLETED
Conditions: Undernutrition|Surgery
Interventions: OTHER: Expiratory muscle training|OTHER: Inspiratory muscle training|OTHER: Sham group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Efficacy and Safety of Inclisiran in Japanese Participants With High Cardiovascular Risk and Elevated LDL-C
Status: COMPLETED
Conditions: Hypercholesterolemia|Heterozygous Familial Hypercholesterolemia
Interventions: DRUG: Inclisiran sodium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of IBI363 in Subjects With Advanced Malignancies
Status: RECRUITING
Conditions: Advanced Malignancies
Interventions: DRUG: IBI363 + chemotherapy|DRUG: IBI363 + Investigator's Choice SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microgreen Consumption for Healthy Aging
Status: COMPLETED
Conditions: Aging|Menopause|Healthy
Interventions: OTHER: Red cabbage microgreens|OTHER: Red beet microgreens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Role of the Gut Microbiota in Pediatric Epilepsy
Status: UNKNOWN
Conditions: Drug Resistant Epilepsy
Interventions: DIETARY_SUPPLEMENT: Prebiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of TQB2618 Injection in Combination With Demethylation Drugs in Patients With Recurrent/Refractory Acute Myeloid Leukemia, Myelodysplastic Syndromes
Status: UNKNOWN
Conditions: Recurrent/Refractory Acute Myeloid Leukemia, Myelodysplastic Syndromes
Interventions: DRUG: TQB2618 injection azacitidine, AZA decitabine, DAC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Limicol on (LDL)-Cholesterol Levels in Moderate Hypercholesterolaemia
Status: COMPLETED
Conditions: Delivery of Health Care
Interventions: DIETARY_SUPPLEMENT: Limicol (plant extract)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Walnuts on Sperm Parameters and Male Fertility
Status: COMPLETED
Conditions: Oligozoospermia|Asthenozoospermia|Teratozoospermia|Fertility
Interventions: DIETARY_SUPPLEMENT: Walnuts|DIETARY_SUPPLEMENT: OTC multivitamin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ProAgio in Combination With Gemcitabine in Patients With Metastatic Triple Negative Breast Cancer
Status: RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: ProAgio Dose Levels (DL) 1,2,3,4|DRUG: ProAgio Dose Expansion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Suture for Mesh Fixation in Lichtenstein Hernia Repair
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: PROCEDURE: suture|PROCEDURE: no suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of NK510 to Treat Gastric Cancer
Status: ENROLLING_BY_INVITATION
Conditions: Gastric Cancer
Interventions: DRUG: NK510|DRUG: Tislelizumab，atezolizumab or Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Tolerability of Topical Terbinafine in Patients With Mild to Moderate Toenail Fungus of the Big Toenail
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DRUG: terbinafine|DRUG: Placebo|DRUG: terbinafine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Devices for Atrial Septal Defects Closure: A Pilot Study
Status: RECRUITING
Conditions: Atrial Septal Defect
Interventions: DEVICE: AMPLATZER™ Septal Occluder.|DEVICE: Occlutech Figulla Flex II®|DEVICE: GORE® CARDIOFORM ASD Occluder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post Market Clinical Study to Evaluate a Mid-Urethral Vaginal Tape Procedure With a Pre-Pubic Delivery Approach, for the Treatment of Stress Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence|Intrinsic Sphincter Deficiency
Interventions: DEVICE: Prefyx PPS™ System|DEVICE: Advantage ™ System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Senicapoc and Dehydrated Stomatocytosis
Status: COMPLETED
Conditions: Dehydrated Hereditary Stomatocytosis
Interventions: DRUG: Senicapoc (synonyms: ICA-17043; 2,2-bis-(4-fluorophenyl)-2-phenylacetamide)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral sucRosomIal Iron on exerciSE Capacity and Quality of Life in Patients With Heart Failure
Status: RECRUITING
Conditions: Chronic Heart Failure|Iron-deficiency|Left Ventricular Systolic Dysfunction
Interventions: DIETARY_SUPPLEMENT: Sucrosomial iron|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Simtuzumab in Adults With Primary, Post Polycythemia Vera or Post Essential Thrombocythemia Myelofibrosis
Status: COMPLETED
Conditions: Myelofibrosis
Interventions: DRUG: Simtuzumab|DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Yaq-001 in Patients With Cirrhosis
Status: TERMINATED
Conditions: Liver Cirrhosis
Interventions: DEVICE: 4g Yaq-001|OTHER: 4g Placebo|DEVICE: 8g Yaq-001|OTHER: 8g Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Robot-assisted Rehabilitation of Hand by Paralysis of the Upper Limb After Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: A-ROM Continuous Passive Rehabilitation|DEVICE: P-ROM Continuous Passive Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adoptive T Cell Therapy, DC Vaccines, and Hematopoietic Stem Cells Combined With Immune checkPOINT Blockade in Patients With Medulloblastoma
Status: NOT_YET_RECRUITING
Conditions: Recurrent Group 3 Medulloblastoma|Recurrent Group 4 (Non-SHH/Non-WNT) Medulloblastoma
Interventions: BIOLOGICAL: TTRNA-DC vaccines with GM-CSF|BIOLOGICAL: TTRNA-xALT|DRUG: Td vaccine|BIOLOGICAL: autologous HSCs|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot and Phase 2 Study of the Efficacy of a Treatment Protocol With Dexamethasone Implant Loading Dose in Patients With Diabetic Macular Edema (LOADEX)
Status: RECRUITING
Conditions: Diabetic Macular Edema
Interventions: DRUG: Dexamethasone with 2 loading doses followed by PRN regimen.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of a Continuous Hepatic Arterial Infusion Combination Therapy With OPC-18 and 5-FU in Patients With Highly Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: OPC-18|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation Of Physical Therapy Protocol In Management Of Chronic Maxillary Sinusitis
Status: NOT_YET_RECRUITING
Conditions: Chronic Maxillary Sinusitis
Interventions: OTHER: physical therapy protocol|OTHER: physical therapy protocol and medical drugs|OTHER: medical drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Guide To Goals: A Novel Care Coordination Tool for Children With Type Two Diabetes (T2D)
Status: COMPLETED
Conditions: Type2 Diabetes Mellitus
Interventions: BEHAVIORAL: Patient and/or Family Member Intervention|BEHAVIORAL: Certified Diabetes Educator Intervention|BEHAVIORAL: Physician Intervention|BEHAVIORAL: Front Desk Staff Intervention|BEHAVIORAL: Nurse Intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p