pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Exploratory Study to Evaluate Various Pharmacodynamic Effects of Subcutaneously Infused or Injected Pramlintide in Obese Subjects
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: DRUG: pramlintide acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Genetically Engineered PBMC and PBSC Expressing NY-ESO-1 TCR After a Myeloablative Conditioning Regimen to Treat Patients With Advanced Cancer
Status: TERMINATED
Conditions: HLA-A*0201 Positive Cells Present|Locally Advanced Malignant Neoplasm|NY-ESO-1 Positive|Unresectable Malignant Neoplasm|Sarcoma
Interventions: OTHER: 18F-FHBG|BIOLOGICAL: Aldesleukin|DRUG: Busulfan|BIOLOGICAL: Cellular Therapy|PROCEDURE: Computed Tomography|BIOLOGICAL: Filgrastim|DRUG: Fludarabine|PROCEDURE: Leukapheresis|DRUG: Plerixafor|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: XEN Glaucoma Gel Stent Versus Trabeculectomy
Status: RECRUITING
Conditions: Primary Open Angle Glaucoma|Pseudoexfoliation Glaucoma|Pigmentary Dispersion Glaucoma
Interventions: DEVICE: surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Protein Blends on Muscle Protein Synthesis in Healthy Older Adults
Status: COMPLETED
Conditions: Muscle Synthesis
Interventions: DIETARY_SUPPLEMENT: Soy Dairy Protein Blend|DIETARY_SUPPLEMENT: Positive Control (Dairy Whey Protein)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of a PIKA Rabies Vaccine Containing the PIKA Adjuvant
Status: COMPLETED
Conditions: Rabies
Interventions: BIOLOGICAL: RABIPUR®|BIOLOGICAL: PIKA rabies vaccine|BIOLOGICAL: PIKA rabies vaccine with an accelerated regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: the Efficacy and Safety of 5-HT3 Receptor Antagonist, Dexamethasone or Megestrol Acetate Dispersible Tablets in the Control of Nausea and Vomiting Induced by Highly Emetogenic Chemotherapy
Status: UNKNOWN
Conditions: Tumor|Chemotherapy-induced Nausea and Vomiting
Interventions: DRUG: Megestrol|DRUG: 5-HT3 receptor antagonist|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Integrated Leading, Managing and Governing for Result Model Towards Institutional Delivery
Status: COMPLETED
Conditions: Leadership
Interventions: BEHAVIORAL: Integrated leading, managing and governing for results model|BEHAVIORAL: Traditional model
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Isolation of Pulmonary Veins With PVAC GOLD in Elderly Patients
Status: COMPLETED
Conditions: Atrial Fibrillation Paroxysmal|Cardiac Arrythmias
Interventions: DEVICE: PVAC GOLD catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Screening and Treatment of SAHS in Patients With Acute Ischemic Stroke
Status: UNKNOWN
Conditions: Ischemic Stroke|Sleep Apnea Syndrome
Interventions: DEVICE: Bi level positive pressure ventilation|DEVICE: bi-level positive airway pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT of Laser Therapy for GSM
Status: COMPLETED
Conditions: Genitourinary Syndrome of Menopause
Interventions: DEVICE: Photothermal Non-ablative Erbium:YAG-laser|DEVICE: Fractional Microablative CO2-laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cohort Study Assessing the Treatment Strategy for High-Risk Myelodysplastic Syndromes in Patients Under 70
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelodysplastic Syndromes
Interventions: PROCEDURE: Allogeneic Stem Cell Transplantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: WalkMore Walking Interventions for Overweight/Obese Postmenopausal Women
Status: COMPLETED
Conditions: Postmenopausal Disorder|Blood Pressure|Over Weight
Interventions: BEHAVIORAL: Basic Intervention|BEHAVIORAL: Enhanced Pedometry|BEHAVIORAL: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation With Mobile Applications in Women With SUI
Status: COMPLETED
Conditions: Urinary Incontinence|Stress Urinary Incontinence
Interventions: DEVICE: Perineal rehabilitation with mobile applications for women with SUI|DEVICE: Classic perineal rehabilitation for women with SUI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Staphylococcus Eradication Protocol for Patients Who Present to the ED With Cutaneous Abscess
Status: COMPLETED
Conditions: Cutaneous Abscess
Interventions: DRUG: Chlorhexidine gluconate|DRUG: Mupirocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intubating Conditions During Propofol-remifentanil Anesthesia With Topical Lidocaine
Status: COMPLETED
Conditions: Drug Usage
Interventions: DRUG: lidocaine|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Cefotaxime and Ceftriaxone on the Emergence and Carrying of Multidrug-Resistant Bacteria
Status: COMPLETED
Conditions: Infection, Bacterial
Interventions: OTHER: Cefotaxime|OTHER: Ceftriaxone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Diagnostic Yield Among M-FISH, FISH Probe Panel and Conventional Cytogenetic Analysis in AML
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DIAGNOSTIC_TEST: Conventional Cytogenetics Studies|DIAGNOSTIC_TEST: Fluorescent in Situ Hybridization (FISH) Panels|DIAGNOSTIC_TEST: Multiplex FISH (M-FISH)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hyaluronidase for Trigger Point Injection in Myofascial Pain Syndrome
Status: COMPLETED
Conditions: Myofascial Pain Syndrome
Interventions: DRUG: trigger point injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Detection of Circulating Endothelial Progenitors Cells (EPCs) in Non-small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer|Chronic Obstructive Pulmonary Disease
Interventions: BIOLOGICAL: Enumeration of endothelial cell progenitor in peripheral blood by flow cytometry, Endothelial cell progenitor characterization by primary cell cultures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treatment of Functional Dyspepsia With Genuine Regional Rhizoma Atractylodis
Status: UNKNOWN
Conditions: Efficiency of Genuine Regional and Non-genuine Regional Rhizoma Atractylodis in Treating FD
Interventions: DRUG: genuine regional Rhizoma Atractylodis (Maozhu granule)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioseal Dural Sealing Study BIOS-14-001
Status: COMPLETED
Conditions: Benign Tumors|Malignant Tumors|Vascular Malformation
Interventions: BIOLOGICAL: Bioseal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of IMN1207 Versus Casein on Weight Loss, Survival and Quality of Life in Non-small Cell Lung Cancer Patients
Status: TERMINATED
Conditions: NON-SMALL CELL LUNG CANCER
Interventions: DIETARY_SUPPLEMENT: IMN1207|DIETARY_SUPPLEMENT: Casein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Food-Effect Bioavailability Study of FDC(Gemigliptin/Metformin HCl Sustained Release) 50/1000mg(25/500mg x 2tablets)
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: FDC(gemigliptin/metformin HCl sustained release 50/1000mg(25/500mg x 2tablets))
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Ultrasound-guided Peripheral Intravenous Catheter Placement in an Oncologic Emergency Department - a Prospective, Randomized Controlled Trial of Catheter Lengths
Status: RECRUITING
Conditions: Oncologic Complications and Emergencies
Interventions: DEVICE: Introcan Safety IV Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of Combination of Traditional Tibetan and Remote Ischemic Conditioning on High Altitude Polycythemia
Status: NOT_YET_RECRUITING
Conditions: High Altitude Polycythemia
Interventions: DEVICE: Remote Ischemic Conditioning|DRUG: Tibetan Medicine (Shiliu Jianwei Powder, Ershiwuwei Yuganzi Pills, Qiwei Tiexue Pill)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Measuring Hydration Levels of Healthy and Heart Failure Patients Before, During, and After an Electrophysiology (EP) Procedure
Status: COMPLETED
Conditions: Cardiac Arrhythmia
Interventions: DEVICE: AleriTM sensors
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase I, Randomized, Single-blind, Controlled, Single Center Study to Evaluate the Safety and Immunogenicity of a Dose Range of a Monovalent Glycoconjugate Antigen Vaccine of Group B Streptococcus in Healthy Women 18-40 Years of Age
Status: COMPLETED
Conditions: Invasive Group B Streptococcus (GBS) Disease
Interventions: BIOLOGICAL: Monovalent GBS-CRM glycoconjugate vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Safety and Tolerability of STSA-1002 Following Subcutaneous Injection in Healthy Subjects
Status: COMPLETED
Conditions: Antineutrophil Cytoplasmic Antibody Associated Vasculitis
Interventions: DRUG: STSA-1002 subcutaneous injection|DRUG: STSA-1002 subcutaneous injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-procedure Antibiotic Prophylaxis for Cardiac Electrical Device Implantation: ABxFREE Study
Status: UNKNOWN
Conditions: Post Procedural Infection|Pacemaker Electrode Infection|Antibiotics|Implantable Defibrillator User
Interventions: DRUG: Antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nicotine Replacement Therapy Sampling for Smokers in the Community
Status: RECRUITING
Conditions: Tobacco Smoking
Interventions: BEHAVIORAL: 1-week nicotine replacement therapy sampling|BEHAVIORAL: Brief cessation advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept Study Comparing FX006 to Kenalog®-40 in Patients With Post-Traumatic Osteoarthritis of the Knee
Status: TERMINATED
Conditions: Post-traumatic Osteoarthritis of the Knee
Interventions: DRUG: FX006 32 mg|DRUG: TCA IR 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Nitrate Functional Gum Effect on Gingivitis and Heart Health
Status: RECRUITING
Conditions: Gingivitis|Cardiovascular Diseases|Gingival Diseases|Gingival Bleeding|Periodontal Diseases
Interventions: DIETARY_SUPPLEMENT: dietary nitrate|OTHER: Placebo chewing gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Wound-healing Improvement by Resurfacing Split-Thickness Skin Donor Sites With Thin Split-thickness Grafting
Status: COMPLETED
Conditions: Skin Graft Disorder|Disorder of Skin Donor Site|Wound Healing Disturbance of
Interventions: PROCEDURE: regrafted with thin split-thickness skin graft|PROCEDURE: covered with the occlusive hydrocellular dressing|PROCEDURE: covered with paraffin gauze
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Assessing Inhibition of Serum Thromboxane B2 Levels With PN400 and Low Dose Aspirin
Status: COMPLETED
Conditions: Platelet Inhibition
Interventions: DRUG: PN400|DRUG: ASA|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Tension-free Repair of Inguinal Hernia With "Undissociate Spermatic Cord"
Status: COMPLETED
Conditions: Inguinal Hernia, Without Mention of Obstruction or Gangrene
Interventions: PROCEDURE: Tension-free repair of inguinal hernia with "Undissociate Spermatic cord"
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hepatitis A Vaccine, Inactivated and Measles, Mumps, Rubella and Varicella Virus Vaccine Live Safety Study (V251-066)(COMPLETED)
Status: COMPLETED
Conditions: Hepatitis A|Measles|Mumps|Rubella|Chickenpox
Interventions: BIOLOGICAL: VAQTA®|BIOLOGICAL: ProQuad
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity of Novel Vaccination Schedules With Malaria Vaccines AdCh63 ME-TRAP and MVA ME-TRAP
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: Vaccination Schedule One|BIOLOGICAL: Vaccination Schedule Two|BIOLOGICAL: Vaccination Schedule Three|BIOLOGICAL: Vaccination Schedule Four|BIOLOGICAL: Vaccination Schedule Five|BIOLOGICAL: Vaccination Schedule Six|BIOLOGICAL: Vaccination Schedule Seven
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Quantifying Artificial Pancreas-related Changes in Diabetic Neuropathy
Status: NOT_YET_RECRUITING
Conditions: Diabetes Complications|Diabetes Mellitus, Type 1|Diabetic Neuropathies
Interventions: DEVICE: Hybrid Closed Loop Insulin Pump
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study Using Ibrutinib and Short-Course Fludarabine in Treatment-Naive CLL
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Ibrutinib|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Azelastine Hydrochloride/ Fluticasone Propionate 137 Microgram/50 Microgram Nasal Spray and Dymista Nasal Spray
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis|Perennial Allergic Rhinitis
Interventions: DRUG: Azelastine Hydrochloride/ Fluticasone propionate nasal spray|DRUG: 'DYMISTA' NASAL SPRAY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Two Combination Chemotherapy Regimens in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: dexamethasone|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Thrive Study: Improving Multimodal Physical Function in Adults With Heterogenous Chronic Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Pain
Interventions: BEHAVIORAL: GetActive-Fitbit|BEHAVIORAL: Healthy Living for Pain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemoradiotherapy Followed by Sequential Immunotherapy for Thoracic Esophageal Squamous Cell Carcinoma
Status: ENROLLING_BY_INVITATION
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: paclitaxel|DRUG: carboplatin|DRUG: tislelizumab|RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Split-dose and Single-dose Bowel Preparation Regimens Using Polyethylene Glycol Electrolyte(PEG)
Status: COMPLETED
Conditions: Bowel Preparation
Interventions: PROCEDURE: different bowel preparation regime|PROCEDURE: traditional bowel preparation regime
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Lipiflow vs iLux Patient Acceptance and Comfort Study
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction|Dry Eye
Interventions: DEVICE: Lipiflow Thermal Pulsation System|DEVICE: iLux System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Azacitidine in Treating Patients With Triple Negative Stage I-IV Invasive Breast Cancer That Can Be Removed By Surgery
Status: WITHDRAWN
Conditions: Recurrent Breast Cancer|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer|Triple-negative Breast Cancer
Interventions: DRUG: azacitidine|OTHER: laboratory biomarker analysis|OTHER: immunohistochemistry staining method|GENETIC: polymerase chain reaction|GENETIC: western blotting|GENETIC: nucleic acid sequencing|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccination of Melanoma Patients With Dendritic Cells Loaded With Allogeneic Apoptotic-Necrotic Melanoma Cells
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: DC/Apo-Nec
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study With GB004 in Adult Subjects With Active Ulcerative Colitis (UC)
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: DRUG: GB004|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Remote Ischemic Preconditioning on the Incidence of Contrast Induced Nephropathy in Patients Undergoing EVAR
Status: COMPLETED
Conditions: Aortic Aneurysm|Ischemic Preconditioning
Interventions: PROCEDURE: Remote ischemic preconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 2 Clinical Trial to Evaluate the Efficacy and Safety of GLH8NDE in Patients With Dry Eye Disease
Status: UNKNOWN
Conditions: Dry Eye Syndromes
Interventions: DRUG: 5% GLH8NDE|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Brimonidine in Patients With Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: Brimonidine ophthalmic solution 0.1%|DRUG: Brimonidine ophthalmic solution 0.2%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot: Combining HIIT and n-3 PUFA Supplementation to Reduce Inflammation and Improve Metabolic Health (HIIT&PUFA)
Status: UNKNOWN
Conditions: Obesity|Inflammation|Insulin Resistance|Dyslipidemias|Gut Microbiome
Interventions: DIETARY_SUPPLEMENT: Omega-3 Polyunsaturated Fatty Acid.|DIETARY_SUPPLEMENT: Safflower Oil|BEHAVIORAL: High-Intensity Interval Training|BEHAVIORAL: Flexibility Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TBI/Flu/Bu/Mel Combined With Secondary UCBT in Patients With Hematological Malignancies Who Relapsed After Allo-HSCT
Status: RECRUITING
Conditions: Hematopoietic Malignancy|Relapse/Recurrence|Hematopoietic Stem Cell Transplantation
Interventions: PROCEDURE: Umbilical Cord Blood Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Community-Based Physiotherapy Versus General Practice
Status: COMPLETED
Conditions: Chronic Disorders
Interventions: PROCEDURE: general practice in primary care and education|OTHER: Multimodal community program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Between Patient Study of Plurogel® Compared to Standard Topical Dressing in Burn Injuries
Status: RECRUITING
Conditions: Burns
Interventions: DRUG: PluroGel|DRUG: Standard dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases|Crohn's Disease
Interventions: DRUG: Placebo|DRUG: MORF-057
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Pelvic Floor Muscle and Abdominal Training in Women With Stress Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence|Pelvic Floor Muscle Weakness
Interventions: OTHER: Pelvic Floor Muscle Training and Abdominal Training|OTHER: Pelvic Floor Muscle Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Remodulin as Add-on Therapy for the Treatment of Persistent Pulmonary Hypertension of the Newborn
Status: TERMINATED
Conditions: Persistent Pulmonary Hypertension of the Newborn
Interventions: DRUG: IV Remodulin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Conscious Sedation With Nitrous Oxide in Control of Stress During Dental Care for Individuals With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: BEHAVIORAL: Control of Stress
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of TCI188 Probiotic on Oral Health
Status: RECRUITING
Conditions: Periodontal Diseases
Interventions: DIETARY_SUPPLEMENT: TCI188 Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Instantaneous Wave-free Ratio Guidance Strategy Evaluation in the Treatment of Multivessel Acute Coronary Syndrome.
Status: UNKNOWN
Conditions: Cardiac Ischemia|Acute Coronary Syndrome
Interventions: PROCEDURE: PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotic Therapy for the Reversal of Bacterial Vaginosis in Pregnancy
Status: COMPLETED
Conditions: Pregnant Women Who Test Positive for Bacterial Vaginosis
Interventions: DRUG: Probiotic Lactobacilli|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Postoperative Nausea and Vomiting (PONV) by Acupressure
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting|Acupressure Point P6
Interventions: DEVICE: Vital-band (R)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Biomarkers in Patients With Rhabdomyosarcoma
Status: COMPLETED
Conditions: Sarcoma
Interventions: GENETIC: DNA methylation analysis|GENETIC: fluorescence in situ hybridization|GENETIC: gene expression analysis|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Bleeding Risk Between Rivaroxaban and Apixaban for the Treatment of Acute Venous Thromboembolism
Status: RECRUITING
Conditions: Venous Thromboembolism
Interventions: DRUG: Apixaban|DRUG: Rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of AMR101 (Ethyl Icosapentate) in Patients With Fasting Triglyceride (Tg) Levels ≥ 500 and ≤ 2000 mg/dL
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DRUG: AMR101 (ethyl icosapentate) - 4 g/day|DRUG: AMR101 (ethyl icosapentate) - 2 g/day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating The Safety And Efficacy Of PF-03654746 In Adult Subjects With Tourette's Syndrome
Status: WITHDRAWN
Conditions: Tourette's Syndrome
Interventions: DRUG: PF-03654746|DRUG: Placebo|DRUG: Placebo|DRUG: PF-03654746
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Food Study of Ondansetron Tablets 24 mg and Zofran® Tablets 24 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ondansetron Tablets 24 mg|DRUG: Zofran® Tablets 24 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cariprazine Versus Placebo for Social Anxiety Disorder
Status: COMPLETED
Conditions: Social Anxiety Disorder
Interventions: DRUG: Cariprazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Design of the Empirical Evaluation of the AISBE Program in Catalonia
Status: COMPLETED
Conditions: Unrecognized Condition
Interventions: OTHER: Home Hospitalization|OTHER: Conventional Hospitalization
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Superior Cervical Sympathetic Block Versus Stellate Ganglion Block in Post-traumatic Subarachnoid Hemorrhage
Status: NOT_YET_RECRUITING
Conditions: Post-Traumatic Subarachnoid Hemorrhage
Interventions: PROCEDURE: Superior cervical sympathetic block group|PROCEDURE: Stellate ganglion block group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of a Water Beverage Intervention for Promoting Modest Weight Reduction in Free Living Adults
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Dietary substitution A|BEHAVIORAL: Dietary Substitution B|BEHAVIORAL: Healthy Choices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SWELE Program: An Unstructured Outdoor Play With Mindfulness-based Interventions to Promote Mental Health Among Students With Special Education Needs
Status: NOT_YET_RECRUITING
Conditions: Specific Learning Disorder|Intellectual Disability, Mild to Moderate|Autism Spectrum Disorder|Attention Deficit Hyperactivity Disorder|Physical Disability
Interventions: BEHAVIORAL: SWELE Programme
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: FACBC PET and PEM as a Staging Tool and Indicator of Therapeutic Response in Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: Positron Emission Tomography (PET)|DRUG: Fluorine-18 labeled 1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC)|PROCEDURE: Positron emission mammography (PEM) When available|PROCEDURE: MR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Thulium Fiber Laser En-bloc Resection vs Conventional Transurethral Resection of Non-muscle-invasive Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: PROCEDURE: Thulium fiber laser en-bloc resection of non-muscle-invasive bladder cancer|PROCEDURE: Transurethral resection of non-muscle-invasive bladder cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Etodolac Tablet USP 500 mg Under Fed Condition
Status: COMPLETED
Conditions: Fed
Interventions: DRUG: Etodolac Tablets USP 500mg|DRUG: Etodolac Tablets USP 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Respiratory Safety of Lemborexant in Adult and Elderly Participants With Moderate to Severe Obstructive Sleep Apnea, and in Adult and Elderly Participants With Moderate to Severe Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive|Pulmonary Disease, Chronic Obstructive|Respiration Disorders
Interventions: DRUG: Placebo|DRUG: Lemborexant 10 mg|DRUG: Placebo|DRUG: Lemborexant 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Open-Label Study of Teprotumumab in Patients With Diabetic Macular Edema (DME)
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Teprotumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicountry, Multicentre, Non-interventional, Retrospective Study to Determine Real-world Treatment Patterns and Associated Outcomes After First Line Osimertinib in Patients With Advanced and Metastatic NSCLC EGFRm in the GCC Region
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Total Body Irradiation and Astatine-211-Labeled BC8-B10 Monoclonal Antibody for the Treatment of Nonmalignant Diseases
Status: SUSPENDED
Conditions: Non-Malignant Neoplasm
Interventions: BIOLOGICAL: Astatine At 211 Anti-CD45 Monoclonal Antibody BC8-B10|DRUG: Fludarabine|DRUG: Cyclophosphamide|BIOLOGICAL: Lapine T-Lymphocyte Immune Globulin|RADIATION: Total-Body Irradiation|PROCEDURE: Hematopoietic Cell Transplantation|DRUG: Mycophenolate Mofetil|DRUG: Sirolimus|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101)
Status: RECRUITING
Conditions: Advanced Solid Tumors|Kirsten Rat Sarcoma (KRAS) pG12C Mutation
Interventions: DRUG: Sotorasib|DRUG: Trametinib|DRUG: RMC-4630|DRUG: Afatinib|DRUG: Pembrolizumab|DRUG: Panitumumab|DRUG: Carboplatin, pemetrexed, docetaxel, paclitaxel|DRUG: Atezolizumab|DRUG: Palbociclib|DRUG: MVASI® (bevacizumab-awwb)|DRUG: TNO155|DRUG: IV Chemotherapy (Regimen 1)|DRUG: IV Chemotherapy (Regimen 2)|DRUG: BI 1701963|DRUG: AMG 404|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastric Sleeve-Induced Weight Loss on Shortness of Breath in Obesity
Status: RECRUITING
Conditions: Dyspnea|Quality of Life
Interventions: DEVICE: Bariatric surgery|BEHAVIORAL: Medical weight loss
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dimercaptosuccinic Acid (DMSA) Treatment of Children With Autism and Heavy Metal Toxicity
Status: COMPLETED
Conditions: Autism
Interventions: DRUG: DMSA - dimercaptosuccinic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Shengyu Decoction and Lijin Manipulation for Knee OA: 3D Gait Analysis
Status: ENROLLING_BY_INVITATION
Conditions: Osteoarthritis of the Knee
Interventions: OTHER: Traditional Chinese medicine combined with manipulation treatment|DRUG: Celecoxib capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial on the Efficacy of Raloxifene on Disease Activity in Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Raloxifene hydrochloride|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Buzzy and Puppet on Pain and Fear
Status: COMPLETED
Conditions: Pain|Fear|Nurse's Role
Interventions: PROCEDURE: Implementation of Bee Buzzy|PROCEDURE: Implementation of Puppet Zuzu
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 1 Study of OLX-07010 in Healthy Adult and Elderly Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: OLX-07010 Active|DRUG: OLX-07010 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Rehabilitation and Additional Physical Training in Elderly Patients After Acute Coronary Syndrome
Status: UNKNOWN
Conditions: Frailty Syndrome|Ischaemic Heart Disease
Interventions: OTHER: Additional balance and resistance training - 1|OTHER: Additional balance and resistance training - 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Psychomotor Therapy as Complimentary Treatment to Patients With Shoulder Pain.
Status: COMPLETED
Conditions: Shoulder Pain
Interventions: OTHER: Psychomotor therapy|OTHER: Physiotherapy|DRUG: corticosteroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Amifostine to Prevent Side Effects in Patients Who Are Receiving Chemotherapy and Radiation Therapy for Limited-Stage Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Drug/Agent Toxicity by Tissue/Organ|Lung Cancer|Radiation Toxicity
Interventions: DRUG: amifostine trihydrate|DRUG: cisplatin|DRUG: etoposide|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vaccine Therapy in Treating Patients With Recurrent or Refractory Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: incomplete Freund's adjuvant|BIOLOGICAL: sargramostim|BIOLOGICAL: tyrosinase peptide|BIOLOGICAL: tyrosinase-related protein-1
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Lodenafil Carbonate in the Treatment of Erectile Dysfunction in Patients With Diabetes.
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: lodenafil carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modified "Providence" Pedi Cast-Sling vs.Cast and Sling
Status: COMPLETED
Conditions: Fractures, Bone|Pediatric ALL
Interventions: DEVICE: Providence Pedi Cast-Sling|DEVICE: Regular sling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maternal Probiotic Intervention to Improve Gut Health
Status: RECRUITING
Conditions: Environmental Enteric Dysfunction|Stunting
Interventions: DRUG: Vivomixx|DEVICE: CapScan®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Compare the Effects of Different AVNS Parameters on Neck Pain, HRV, Balance in Collegiate Atheletes
Status: RECRUITING
Conditions: Neck Pain|Heart Rate Variability|Balance
Interventions: DEVICE: Auricular vagus nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study With Pembrolizumab for Non-small Cell Lung Cancer (NSCLC)
Status: UNKNOWN
Conditions: Non-small-lung-cell Cancer, NSCLC|Pembrolizumab
Interventions: DRUG: A) Standard maintenance programme group, pembrolizumab 200mg, every 3 weeks, for a total of 2 years of follow-up and follow-up for 1 year;|DRUG: B) Improvement maintenance programme group, pembrolizumab 200mg, every 6 weeks, for a total of 2 years of follow-up and 1 year follow-up;
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Vitamin B3 on Substrate Metabolism, Insulin Sensitivity, and Body Composition in Obese Men
Status: COMPLETED
Conditions: Obese
Interventions: DIETARY_SUPPLEMENT: Nicotinamide riboside (NIAGEN TM, ChromaDex, CA, USA )|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enteric Immune-nutrition Formula (ANOM®) for Patients Receiving Major Upper Gastrointestinal Surgery
Status: UNKNOWN
Conditions: Chronic Upper Gastrointestinal Hemorrhage
Interventions: DIETARY_SUPPLEMENT: ANOM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Action of Essential Fatty Acids on the Expression of Antioxidant Genes and Athletic Performance
Status: COMPLETED
Conditions: Oxidative Stress|Exercise|Training Season|Antioxidant Capabilities|Athletic Performance
Interventions: DIETARY_SUPPLEMENT: Docosahexaenoic acid diet supplementation|DIETARY_SUPPLEMENT: Placebo supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bilirubin Neurotoxicity (BN) and Neurodevelopmental Impairment (NDI) in Extremely Preterm (EP) Infants: Avoidable by Reducing the Usual Intravenous Lipid (UL) Administration
Status: RECRUITING
Conditions: Bilirubin Encephalopathy
Interventions: DRUG: usual prescribed intralipid (UL) regimen|DRUG: restricted prescribed intralipid (RL) regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Robotic Assisted Gait Training as an Adjunct to Traditional Physiotherapy in Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: DEVICE: Lokomat training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Exploration of Optimal Treatment Scheme in Patients With Type 2 Diabetes Inadequately Controlled With Glargine
Status: UNKNOWN
Conditions: Type2 Diabetes
Interventions: COMBINATION_PRODUCT: Optimal hypoglycemic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of VC Versus PC Ventilation on Cerebral and Respiratory Parameters in Patients Undergoing Laparoscopic Gynecologic Surgery
Status: RECRUITING
Conditions: Anesthesia|Gynecologic Cancer|Mechanical Ventilation Complication
Interventions: PROCEDURE: Mechanical Ventilation Mode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Peer-Driven Intervention to Enroll Minorities/Women in HIV/AIDS Clinical Trials (the ACT2 Project)
Status: COMPLETED
Conditions: HIV Infections
Interventions: BEHAVIORAL: Peer-driven intervention|BEHAVIORAL: Time-matched health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: AZD5423 Single Ascending Dose Study
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: AZD5423|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Pueraria Lobata Radix as an Adjuvant Treatment for Type 2 Diabetes Mellitus
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Pueraria lobata radix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Women
Status: RECRUITING
Conditions: Transgender|Gender Identity|Vascular Stiffness|Vascular Inflammation|Insulin Sensitivity|Blood Pressure|Lipid Disorder|Appetitive Behavior
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multiparametric MRI for Prostate Cancer Localization and Characterization Using Hyperpolarized Pyruvate (13C) Injection
Status: WITHDRAWN
Conditions: Prostatic Neoplasms
Interventions: DRUG: Hyperpolarized Pyruvate (13C) Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase I Study to Assess Absorption, Metabolism & Excretion of a Single Oral Dose [14C]AZD0530 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: [14C] AZD0530
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Investigation of Short Course, High Dose Primaquine Treatment for Liver Stages of Plasmodium Vivax Infection
Status: UNKNOWN
Conditions: Plasmodium Vivax
Interventions: DRUG: Primaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Qualitative and Quantitative Endothelium Changes After Cataract Surgery: Ultrasound Phacoemulsification vs Nanolaser Technique
Status: COMPLETED
Conditions: Effect of Cataract Surgery on Corneal Endothelium; About 2 Techniques
Interventions: PROCEDURE: phacoemulsification|PROCEDURE: utrasound phacoemulsification|PROCEDURE: nanolaser phacoemulsification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Metformin on Airway Ion Channel Dysfunction in Cystic Fibrosis-related Diabetes
Status: RECRUITING
Conditions: Cystic Fibrosis-related Diabetes|Cystic Fibrosis
Interventions: DRUG: Metformin Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics and Recovery From Surgery
Status: TERMINATED
Conditions: Major Abdominal Operation
Interventions: DIETARY_SUPPLEMENT: VSL #3 BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison Of Rituximab Versus Tositumomab and Iodine I 131 Tositumomab (BEXXAR® Therapeutic Regimen) For Patients With Relapsed Follicular Non-Hodgkins Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin
Interventions: BIOLOGICAL: Tositumomab and Iodine I 131 Tositumomab|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT