pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of Preparing Parents To Participate In Their Child's Care In The Recovery Room
Status: COMPLETED
Conditions: Perioperative Nursing
Interventions: BEHAVIORAL: "You and your child in the recovery room" DVD|BEHAVIORAL: Standard pre-operative preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Effects of Peroneal Nerve Functional Electrical Stimulation (WalkAide[R]) for Chronic Stroke Patients
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: gait training with WA|OTHER: usual gait training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder
Status: RECRUITING
Conditions: Bipolar I Disorder|Psychosis|Schizoaffective Disorder
Interventions: OTHER: Ketogenic diet|OTHER: Dietary Guidelines for Americans
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anterior Prolapse Repair With and Without Graft Augmentation
Status: COMPLETED
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: dermal graft (ARCUS repliform) for anterior colporrhaphy|PROCEDURE: suture based anterior colporrhaphy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acalabrutinib in Combination With R-ICE For Relapsed or Refractory Lymphoma
Status: TERMINATED
Conditions: Diffuse Large B Cell Lymphoma|Chronic Lymphocytic Leukemia|Small Lymphocytic Leukemia|Marginal Zone Lymphoma
Interventions: DRUG: Acalabrutinib|DRUG: Rituximab|DRUG: Ifosfamide|DRUG: Carboplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1b DV281 With an Anti-PD-1 Inhibitor in NSCLC
Status: COMPLETED
Conditions: Advanced Non Small Cell Lung Cancer
Interventions: DRUG: DV281|DEVICE: Breath Actuated Nebulizer|DRUG: DV281 (RP2D)|DRUG: Approved Anti-PD-1 Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Aimed At Improving Height With Genotonorm In Children Born Little And/Or Light With Growth Retardation At The Age
Status: COMPLETED
Conditions: Fetal Growth Retardation
Interventions: DRUG: Genotonorm (Somatropin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Customization of Cardiac Readaptation Based on Force-velocity Profile and Heart Rate Variability
Status: RECRUITING
Conditions: Acute Coronary Syndrome
Interventions: OTHER: training strategy with adaptation of training strategies to the ANS|OTHER: training strategy (standard practice)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Naltrexone RCT for Treatment-Emergent Fatigue in Patients Receiving Radiation Therapy for Breast Cancer
Status: TERMINATED
Conditions: Invasive Breast Cancer (Stage I-III)|Ductal Carcinoma in Situ|Lobular Carcinoma in Situ|Lobular Carcinoma|Fatigue Related to Cancer Treatment
Interventions: DRUG: Naltrexone|DRUG: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Alveolar-decortication on Velocity of Tooth Movement
Status: COMPLETED
Conditions: Palatally Impacted Canines
Interventions: PROCEDURE: Alveolar-decortication.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gabapentin for Smoking Cessation
Status: COMPLETED
Conditions: Cigarette Smoking|Tobacco Use
Interventions: DRUG: Placebo|DRUG: Gabapentin - 1800 mg/day|DRUG: Gabapentin - 2700 mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of Hylan G-F 20 (Synvisc) in Patients With Symptomatic Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Musculoskeletal Diseases
Interventions: DEVICE: hylan G-F 20|OTHER: Phosphate Buffered Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study in Patients With Untreated Multiple Myeloma and Renal Insufficiency
Status: COMPLETED
Conditions: Multiple Myeloma|Renal Insufficiency
Interventions: DRUG: BHQ880|DRUG: BHQ880 Placebo|DRUG: bortezomib|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Lenalidomide as a Treatment for Neuropathy Associated With Monoclonal Gammopathy of Undetermined Significance
Status: TERMINATED
Conditions: Neuropathy|Nonmalignant Monoclonal Gammopathy of Undetermined Significance (MGUS)
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 3 Study of Carfilzomib, Melphalan, Prednisone vs Bortezomib, Melphalan, Prednisone in Newly Diagnosed Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Carfilzomib|DRUG: Bortezomib|DRUG: Melphalan|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet Rich Fibrin+1% Alendronate in Treatment of Chronic Periodontitis
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: PROCEDURE: Open flap debridement (OFD)|PROCEDURE: OFD with Platelet rich fibrin (PRF)|PROCEDURE: OFD with Platelet rich fibrin (PRF)+1% Alendronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab With Carboplatin Compared to Carboplatin Alone in Breast Cancer Patients With Chest Wall Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Chest Wall Disease
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Carboplatin|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Expectations in Experimentally Induced Sadness
Status: COMPLETED
Conditions: Healthy Participants
Interventions: OTHER: Placebo nasal spray|OTHER: Film Sequence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: BivaLirudin versUS Heparin in Extracorporeal Membrane Oxygenation
Status: RECRUITING
Conditions: Extracorporeal Membrane Oxygenation Complication
Interventions: DRUG: Unfractionated heparin|DRUG: Bivalirudin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of SP-624 in the Treatment of Adults With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: SP-624|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Alpha-Lipoic Acid Supplementation on the Incidence of Postoperative Atrial Fibrillation in Cardiac Surgery Patients
Status: RECRUITING
Conditions: Postoperative Atrial Fibrillation
Interventions: DRUG: Alpha Lipoic Acid 600 MG Oral Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Non-Hormonal Vaginal Moisturizer in Hormone-Receptor Positive Postmenopausal Cancer Survivors Experiencing Estrogen Deprivation Symptoms on Vulvovaginal Health
Status: COMPLETED
Conditions: Breast Cancer|Endometrial Cancer
Interventions: OTHER: HLA vaginal gel (HyaloGYN®),|BEHAVIORAL: questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Anesthetic Continuous Preperitoneal Infiltration and Wound Hyperalgesia
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: continuous ropivacaine preperitoneal infusion|DRUG: intravenous lidocaine infusion|DRUG: parenteral analgesia combining acetaminophen and morphine|DRUG: NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Social Isolation on the Role of Pavlovian Mechanisms for Control Over Alcohol Use
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use Disorder|Alcoholism|Stress Reaction|Ostracism|Substance Use Disorders
Interventions: BEHAVIORAL: PIT paradigm|BEHAVIORAL: social exclusion (Cyberball task)|DIAGNOSTIC_TEST: Saliva samples|DIAGNOSTIC_TEST: basic psychological assessment|DIAGNOSTIC_TEST: pre and post cyberball task|DIAGNOSTIC_TEST: VAS|DIAGNOSTIC_TEST: after cyberball task|BEHAVIORAL: social inclusion (Cyberball task)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Efficacy of Adding Interpersonal and Emotional Processing Therapy Techniques to Cognitive Behavioral Therapy to Treat Generalized Anxiety Disorder
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: BEHAVIORAL: CBT|OTHER: Interpersonal and emotional processing therapy|BEHAVIORAL: supportive listening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of CGRP Monoclonal Antibody to Treat Diabetic Neuropathy
Status: RECRUITING
Conditions: Diabetic Polyneuropathy
Interventions: DRUG: Eptinezumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Medication Adherence in Schizophrenia: Development of a CBT-Based Intervention
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Study to Determine the Safety and Efficacy of LX3305 in Subjects With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: 50 mg LX3305 QD|DRUG: 100 mg LX3305 QD|DRUG: 150 mg LX3305 QD|DRUG: 200 mg LX3305 QD|DRUG: 250 mg LX3305 QD|DRUG: 300 mg LX3305 QD|DRUG: 400 mg LX3305 QD|DRUG: 250 mg LX3305 BID|DRUG: 500 mg LX3305 QD|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Standard Maintenance Therapy (SMT) vs Local Consolidative Radiation Therapy and SMT in OM-NSCLC
Status: RECRUITING
Conditions: Oligometastatic Disease|Metastatic Non Small Cell Lung Cancer
Interventions: RADIATION: Local consolidative radiation therapy|DRUG: Standard maintenance therapy as decided by the treating medical oncologist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Lung Volume Recruitment Technique After Extubation
Status: COMPLETED
Conditions: Mechanical Ventilation Complication|Diaphragm Issues|Cough|Ineffective Airway Clearance|Intensive Care Unit Acquired Weakness
Interventions: DEVICE: Lung volume recruitment technique|OTHER: Traditional chest physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study Adding Drugs to Usual Treatment for Large B-Cell Lymphoma That Returned or Did Not Respond to Treatment
Status: RECRUITING
Conditions: Grade 3b Follicular Lymphoma|High Grade B-Cell Lymphoma|High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements|Recurrent Diffuse Large B-Cell Lymphoma|Refractory Diffuse Large B-Cell Lymphoma|Transformed Non-Hodgkin Lymphoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Lenalidomide|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|BIOLOGICAL: Tafasitamab|DRUG: Tazemetostat|DRUG: Zanubrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritional and Culinary Habits to Empower Families Towards Sustainability - a Multicentric Pilot Study
Status: RECRUITING
Conditions: Family Research
Interventions: BEHAVIORAL: Nutritional and culinary intervention|BEHAVIORAL: Nutritional intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of SPARC0921 in Subjects With Spasticity
Status: COMPLETED
Conditions: Spasticity
Interventions: DRUG: SPARC0921|DRUG: Placebo0921
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Evaluation of Etonogestrel (ENG) Implant and Antiretroviral Therapy
Status: COMPLETED
Conditions: HIV|Contraception
Interventions: DRUG: Etonogestrel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Point of Care Testing to Improve Monitoring of LVAD Patients
Status: WITHDRAWN
Conditions: Anticoagulation and Thrombosis Point of Care Test (AT-POCT)
Interventions: DEVICE: Anticoagulation and Thrombosis Point of Care Test(AT-POCT)|DEVICE: Duke Central Automated Laboratory (DCAL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Multicenter Study of the Safety and Efficacy of NAFT-500 in Tinea Cruris
Status: COMPLETED
Conditions: Tinea Cruris|Jock Itch
Interventions: DRUG: NAFT-500|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Three Dosing Regimens of Dextromethorphan (DXM) Reportedly Used in Major Depressive Disorder
Status: COMPLETED
Conditions: MDD|Treatment Resistant Depression|Smoking Cessation|Smoking
Interventions: DRUG: Dextromethorphan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Learn About the Long-term Safety of Rimegepant for the Acute Treatment of Migraine in Chinese Participants
Status: COMPLETED
Conditions: Acute Migraine
Interventions: DRUG: Rimegepant 75mg Orally Disintegrating Tablets (ODT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: G-CSF+DAC+BUCY vs G-CSF+DAC+BF Conditioning Regimen for High-risk MDS Undergoing Allo-HSCT
Status: RECRUITING
Conditions: Myelodysplastic Syndrome|Allogeneic Hematopoietic Stem Cell Transplantation|Conditioning
Interventions: DRUG: Granulocyte Colony-Stimulating Factor(G-CSF)|DRUG: Decitabine (DAC)|DRUG: Busulfan|DRUG: Fludarabine (FLU)|DRUG: Cyclophosphamide (CY)|DRUG: Busulfan (BU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin in PIPAC for Nonresectable Peritoneal Metastases of Digestive Cancers
Status: TERMINATED
Conditions: Digestive Cancer
Interventions: DRUG: 5-Fluorouracil|DRUG: L-Folinic acid|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Combined Use of Indoor Residual Spraying (IRS) and Long-lasting Insecticidal Nets (LLINs) for Malaria Prevention
Status: UNKNOWN
Conditions: Malaria
Interventions: OTHER: Indoor residual spraying with bendiocarb|OTHER: LLIN by universal coverage campaign
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: REcruitment MAneuvers and Mechanical Ventilation Guided by EIT in pARDS
Status: RECRUITING
Conditions: ARDS|Pediatric Respiratory Distress Syndrome|Respiratory Disease
Interventions: DEVICE: EIT measurement|DEVICE: Staircase Recruitment Maneuvers with EIT guided and decremental PEEP trial|DEVICE: Setting of EIT-guided mechanical ventilation|DEVICE: Reevaluation after 24 h
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nivolumab Plus Epacadostat in Combination With Chemotherapy Versus the EXTREME Regimen in Squamous Cell Carcinoma of the Head and Neck (CheckMate 9NA/ECHO-310)
Status: WITHDRAWN
Conditions: Head and Neck Cancer
Interventions: DRUG: Nivolumab|DRUG: Epacadostat|DRUG: Placebo|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Cetuximab|DRUG: 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Women's Quality of Life, Sexual Life and Psychological State in Patients Undergoing Embryo Transfers
Status: UNKNOWN
Conditions: Infertility, Female|Anxiety State|Depression|Quality of Life|Sexual Function and Fertility Disorders
Interventions: OTHER: Filling out the forms including IDAS-II, BAI, SF-36 and FSFI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: StrataGraft® Skin Tissue as an Alternative to Autografting Deep Partial-Thickness Burns
Status: COMPLETED
Conditions: Skin Wound|Burns|Trauma-related Wound
Interventions: BIOLOGICAL: StrataGraft Skin Tissue
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of 2 Schedules of Ixabepilone Plus Bevacizumab and Paclitaxel Plus Bevacizumab for Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Ixabepilone, 16 mg/m^2 + Bevacizumab, 10 mg/kg|DRUG: Ixabepilone, 40 mg/m^2 + Bevacizumab, 15 mg/kg|DRUG: Paclitaxel, 90 mg/m^2 + Bevacizumab, 10 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Leveling and Alignment of Maxillary Anterior Teeth Assisted With MOPs :A Comparative Clinical Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Crowding of Anterior Maxillary Teeth
Interventions: PROCEDURE: microosteoperforations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Researching Cardiovascular Events With a Weekly Incretin in Diabetes (REWIND)
Status: COMPLETED
Conditions: Cardiovascular Disease|Diabetes Mellitus, Type 2
Interventions: DRUG: Dulaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of an Anticancer Medication Combined With Immune Cells in Subjects With Solid Tumors
Status: UNKNOWN
Conditions: Advanced Solid Tumors
Interventions: BIOLOGICAL: An anticancer medication (A01) and immune cells (IC01)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sodium Nitroprusside on Cerebral Blood Flow
Status: COMPLETED
Conditions: Healthy Male Subjects
Interventions: OTHER: Hyperventilation|OTHER: 6% CO2 breathing|DRUG: Infusion of sodium nitroprusside
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Drug-Drug Interaction Study of Intravenous Administration of SyB V-1901 and Cyclosporine in Japanese Healthy Subjects
Status: COMPLETED
Conditions: Drug Drug Interaction
Interventions: DRUG: SyB V-1901|DRUG: Cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Theory of Mind-based Social Competence Group Intervention
Status: NOT_YET_RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Theory of mind-based social competence group intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Investigate HCV Response Rates in Real World Patients: HEARTLAND Study
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: paritaprevir/ritonavir/ombitasvir + dasabuvir +/- ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Drug Combinations Against Trichuris Trichiura
Status: COMPLETED
Conditions: Parasitic Diseases
Interventions: DRUG: albendazole|DRUG: mebendazole|DRUG: ivermectin|DRUG: albendazole + ivermectin|DRUG: mebendazole + ivermectin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Community-Based Continence Promotion: Sustaining Healthy Aging in Place (SHAIP) Through Mind Over Matter (MOM)
Status: COMPLETED
Conditions: Fecal Incontinence in Old Age|Urinary Incontinence in Old Age
Interventions: BEHAVIORAL: Mind Over Matter; Healthy Bowels, Healthy Bladder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EGEN-001 in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Fallopian Tube Carcinoma|Primary Peritoneal Carcinoma|Recurrent Ovarian Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: PEG-PEI-cholesterol Lipopolymer-encased IL-12 DNA Plasmid Vector GEN-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ADP-A2M4CD8 Monotherapy and in Combination With Nivolumab in HLA-A2+ Subjects With MAGE-A4 Positive Ovarian Cancer (SURPASS-3)
Status: RECRUITING
Conditions: Ovarian Cancer
Interventions: GENETIC: Autologous genetically modified ADP-A2M4CD8 cells|COMBINATION_PRODUCT: Autologous genetically modified ADP-A2M4CD8 cells in combination with Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of a Method for Analysis of Alzheimer´s Disease Specific Proteins in Nasal Secretion
Status: RECRUITING
Conditions: Nasal Secretion|Alzheimer Disease|Brain Nose Interface
Interventions: DIAGNOSTIC_TEST: Collection of nasal secretion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Investigation to Evaluate the Safety and Efficacy of Dressing CONNETTIVINA HI TECH in the Management of Superficial Cutaneous Lesions
Status: TERMINATED
Conditions: Superficial Cutaneous Lesions
Interventions: DEVICE: CONNETTIVINA HI TECH patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Targeted Intervention for Topical Steroid Phobia.
Status: COMPLETED
Conditions: Dermatologic Disease|Phobia|Adherence, Medication
Interventions: BEHAVIORAL: Targeted education|BEHAVIORAL: Online disease specific forum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Is There a New Gold Standard for the Treatment of Obsessive-Compulsive Disorder?
Status: WITHDRAWN
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: H7 coil|DEVICE: Cool D-B80|BEHAVIORAL: Exposure Response Prevention (ERP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Synchronous Telerehabilitation vs Face to Face Method for Upper Extremity Functions in Children With Hemiparetic CP
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: Telerehabilitation|OTHER: Face to face rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Testing LOXO-101 as Potentially Targeted Treatment in Cancers With NTRK Genetic Changes (MATCH - Subprotocol Z1E)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lymphoma|Advanced Malignant Solid Neoplasm|Refractory Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Multiple Myeloma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Larotrectinib|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Inhibition of [11C]R-rolipram Binding to Brain Phosphodiesterase - 4 (PDE-4) by HT-0712
Status: TERMINATED
Conditions: Healthy Elderly Volunteers
Interventions: DRUG: HT-0712
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Effectiveness and Safety of Evolut R Valve In Patients With Pure Aortic Regurgitation
Status: TERMINATED
Conditions: Aortic Valve|Aortic Valve Insufficiency|Aortic Regurgitation|Regurgitation, Aortic Valve|Aortic Incompetence
Interventions: DEVICE: TAVR with Evolut R valve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of the Safe and Sound Protocol on PTSD Symptoms and Anxiety
Status: COMPLETED
Conditions: Post Traumatic Stress Disorder|Anxiety
Interventions: DEVICE: Safe and Sound Protocol|BEHAVIORAL: Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Low-osmolaric Glucose Polymer Drink for Gastric Distress and Running Performance
Status: COMPLETED
Conditions: Gastric Distress|Running Performance
Interventions: OTHER: Sports drink 1|OTHER: Sports drink 2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: DFA-02 in Patients Undergoing Colorectal Surgery
Status: COMPLETED
Conditions: Surgical Site Infection
Interventions: DRUG: DFA-02|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aerobic And Strength Training Exercises For Restless Leg Syndrome In Patients With Diabetes
Status: COMPLETED
Conditions: Restless Legs Syndrome|Diabetes
Interventions: OTHER: Aerobic training|OTHER: strength training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of 18F-Fluoromethylcholine (18F-FCH) PET/CT in Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: 18F-Fluoromethylcholine (18F-FCH)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Optimal Strategy of Switching From Clopidogrel to Ticagrelor in Patients With Complexity of Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease|Ticagrelor
Interventions: DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of 6 mL Synvisc-One (Hylan G-F 20) in Indian Patients With Symptomatic Osteoarthritis of Knee(s) After Initial and Repeat Treatment
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Synvisc-One
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TDCS in Pediatric and Teenage Patients With Major Depressive Disorder During COVID-19 Pandemic
Status: UNKNOWN
Conditions: Major Depressive Disorder
Interventions: DEVICE: Transcranial Direct Current Stimulation|DEVICE: Placebo-simulation of transcranial direct current stimulation|DRUG: Fluoxetine Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Extension Study to Evaluate the Long-Term Efficacy, Safety and Tolerability of Minzasolmin (UCB0599) in Study Participants With Parkinson's Disease
Status: ENROLLING_BY_INVITATION
Conditions: Parkinson's Disease
Interventions: DRUG: Minzasolmin (UCB0599)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Family Approach to Managing Asthma in Early Teens
Status: COMPLETED
Conditions: Asthma|Lung Diseases
Interventions: BEHAVIORAL: Asthma: It's a Family Affair!|BEHAVIORAL: Asthma and Stress Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TP05 for the Treatment of Mild to Moderate Active Ulcerative Colitis (UC)
Status: COMPLETED
Conditions: Acute Ulcerative Colitis
Interventions: DRUG: TP05|DRUG: Asacol 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Oral Nutrition Supplementation in Malnourished Surgical Cancer Patients
Status: COMPLETED
Conditions: Cancer of Breast|Cancer Colon
Interventions: DIETARY_SUPPLEMENT: ONS Pre-op + ONS Post-op|DIETARY_SUPPLEMENT: ONS Pre-op + ONS Post-op + ONS Post-op 3 months|DIETARY_SUPPLEMENT: Usual intake Pre-op + ONS Post-op
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vasculaire Leg Compression Device for the Treatment of Restless Legs Syndrome - A Prospective Clinical Study
Status: WITHDRAWN
Conditions: Restless Legs Syndrome,|Restless Legs,|Ekbom Syndrome
Interventions: DEVICE: Venous Health Systems Vasculaire Leg Compression Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mirabegron And Ureteral Stent-related Pain (MAP) Trial
Status: UNKNOWN
Conditions: Nephrolithiasis
Interventions: DRUG: Mirabegron 50 MG|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GATT-Patch Versus TachoSil in Liver Surgery
Status: COMPLETED
Conditions: Intraoperative Bleeding|Hemorrhage, Surgical|Liver Diseases
Interventions: DEVICE: GATT-Patch|DRUG: TachoSil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Chemoradiotherapy Combined With or Without PD-1 Blockade in Anal Canal Squamous Carcinoma Patients
Status: RECRUITING
Conditions: Anal Canal Cancer Stage III|Anal Squamous Cell Carcinoma|Anal Canal Cancer|Anal Cancer
Interventions: DRUG: PD-1 inhibitor|RADIATION: concurrent chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study on "Functional Overlay" in Patients With Movement Disorders
Status: RECRUITING
Conditions: Conversion Disorder|Parkinson Disease|Tremor|Dystonia
Interventions: DIAGNOSTIC_TEST: Neurological examination|DIAGNOSTIC_TEST: Anamnesis|DIAGNOSTIC_TEST: Neuropsychological testing|DIAGNOSTIC_TEST: Questionnaires|DIAGNOSTIC_TEST: Tremor recording
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comparison of SYMBICORT® pMDI With Budesonide HFA pMDI in African American Subjects With Asthma.
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Budesonide/formoterol (SYMBICORT) pMDI|DRUG: Budesonide HFA pMDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Netarsudil vs Brimonidine in NTG Patients on Latanoprost
Status: RECRUITING
Conditions: Normal Tension Glaucoma
Interventions: DRUG: Netarsudil|DRUG: Brimonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pulmonary Function Test Changes and Respiratory Muscle Strength Trends in Spinal Muscular Atrophy Patients Receiving Nusinersen Treatments
Status: WITHDRAWN
Conditions: Spinal Muscular Atrophy
Interventions: DRUG: Nusinersen Treatments
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of the Edwards Aortic Bioprosthesis, Model 11000
Status: COMPLETED
Conditions: Aortic Valve Disorder|Aortic Valve Insufficiency|Aortic Valve Stenosis|Heart Failure|Coronary Artery Disease
Interventions: PROCEDURE: Heart Valve Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Onivyde Manufactured at Two Different Production Sites in Adult Participants With Advanced Cancer in the Pancreas
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: Irinotecan liposome injection|DRUG: Irinotecan liposome injection|DRUG: Irinotecan liposome injection|DRUG: Irinotecan liposome injection|DRUG: Folinic Acid|DRUG: 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Ceftaroline Versus Linezolid in Subjects With Complicated Skin and Skin Structure Infections
Status: COMPLETED
Conditions: Bacterial Infection
Interventions: DRUG: ceftaroline|DRUG: linezolid|DRUG: Aztreonam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BetterBirth: A Trial of the WHO Safe Childbirth Checklist Program
Status: COMPLETED
Conditions: Maternal Death|Maternal Morbidity|Stillbirth|Neonatal Death
Interventions: BEHAVIORAL: WHO Safe Childbirth Checklist Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Writing Interventions in Breast Cancer Patients Taking Aromatase Inhibitors
Status: RECRUITING
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Value Affirmation|BEHAVIORAL: Reflective Journaling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of FemVue(TM) Sono Tubal Evaluation System Method Comparison to HSG
Status: WITHDRAWN
Conditions: Fallopian Tube Patency Tests
Interventions: DEVICE: Sonography with FemVue, and HSG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: BKM120 + Carboplatin + Paclitaxel for Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: BKM120 days 1 - 21 plus paclitaxel + carboplatin|DRUG: BKM120 (days 1 - 28, ) plus paclitaxel + carboplatin|DRUG: BKM120 (days 1-21) + paclitaxel (day 1) + carboplatin (day 1)|DRUG: BKM120, Paclitaxel + Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Attachment Style and Mentalization Impact Among Women Victims of Domestic Violence
Status: UNKNOWN
Conditions: Violence, Domestic
Interventions: BEHAVIORAL: Semi-structured interviews|BEHAVIORAL: Projective methode|BEHAVIORAL: Selfreported
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CMV-MVA Triplex Vaccination of Stem Cell Donors in Preventing CMV Viremia in Participants With Allogeneic Transplant
Status: ACTIVE_NOT_RECRUITING
Conditions: Accelerated Phase CML, BCR-ABL1 Positive|Acute Lymphoblastic Leukemia in Remission|Acute Myeloid Leukemia in Remission|Chronic Lymphocytic Leukemia|Chronic Phase CML, BCR-ABL1 Positive|Cytomegalovirus Positive|Donor|Hematopoietic Cell Transplant Recipient|Hodgkin Lymphoma|Myelodysplastic Syndrome|Myelodysplastic/Myeloproliferative Neoplasm|Non-Hodgkin Lymphoma|Myelofibrosis|Hematopoietic and Lymphoid Cell Neoplasm
Interventions: BIOLOGICAL: Multi-peptide CMV-Modified Vaccinia Ankara Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Contrast-Enhanced Ultrasound in Predicting Treatment Response in Patients With Kidney Cancer Undergoing Cryosurgery
Status: WITHDRAWN
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Perflutren Protein-Type A Microspheres|PROCEDURE: Dynamic Contrast-Enhanced Ultrasound Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Consolidation Strategies for Pediatric Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: AML|Pediatric AML
Interventions: DRUG: ARM A: Active Comparator Drug|DRUG: ARM B: Blocks Therapy Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Research on the Economics of Artemisinin Combination Therapy (ACTs) for the Treatment of Malaria
Status: COMPLETED
Conditions: Malaria
Interventions: BEHAVIORAL: RDTs & Provider Training on Malaria Diagnosis and Treatment|BEHAVIORAL: Extended provider training (Cameroon only)|BEHAVIORAL: School based malaria education (Nigeria only)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Intraoperative Music Listening on Sevoflurane Consumption and Recovery Parameters
Status: RECRUITING
Conditions: Anesthesia|Stress|Music|Auditory Perception
Interventions: OTHER: music listening during anesthesia|OTHER: absence of music listening during anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Test of Mastication and Swallowing Solids and the Timed Water Swallow Test
Status: COMPLETED
Conditions: Healthy Aging|Gender|Swallowing Disorder
Interventions: DIAGNOSTIC_TEST: The Test of Mastication and Swallowing Solids (TOMASS) and the Timed Water Swallow Test (TWST)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Translating Intensive Arm Rehabilitation in Stroke to a Telerehabilitation Format
Status: COMPLETED
Conditions: Stroke|Hemiparesis
Interventions: DEVICE: Home-Based BATRAC plus TTT|DEVICE: Lab-based BATRAC plus TTT|BEHAVIORAL: Delayed Entry Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison Between Titanium Femoral Stem and Cobalt-Chromium Femoral Stem in Cemented Hip Arthroplasty
Status: WITHDRAWN
Conditions: Osteoarthritis
Interventions: DEVICE: Bi-Metric femoral implant (titanium versus cobalt-chromium)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selective Neck Dissection Versus Modified Neck Dissection in PTC
Status: NOT_YET_RECRUITING
Conditions: Thyroid Cancer
Interventions: PROCEDURE: Lymph node tracer navigated selective neck dissection|PROCEDURE: Modified neck dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cetuximab + Avelumab or Avelumab Alone for Unresectable, Locally Advanced or Metastatic Squamous Cell Anal Carcinoma (SCCAC) Progressed After at Least One Line of Systemic Treatment (CARACAS)
Status: UNKNOWN
Conditions: Squamous Cell Anal Carcinoma
Interventions: DRUG: Avelumab|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BuCY vs TBICY Conditioning Regimen for Standard-risk ALL Undergoing Allo-HSCT
Status: COMPLETED
Conditions: Allogeneic Hematopoietic Stem Cell Transplantation|Busulfan|Total Body Irradiation|Acute Lymphocytic Leukemia
Interventions: DRUG: Busulfan (BU)|DRUG: Cyclophosphamide (CY)|RADIATION: Total Body Irradiation (TBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiologic Effects of High Flow Nasal Therapy in Patients With Acute Hypoxemic Respiratory Failure (OPTIFLOW)
Status: COMPLETED
Conditions: Respiratory Failure
Interventions: PROCEDURE: O2stand|PROCEDURE: CPAP|PROCEDURE: Optiflow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Transportable Customizable and Scalable Sitting Positioning Device on Swallowing Disorders
Status: COMPLETED
Conditions: Deglutition Disorders
Interventions: DEVICE: DATP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: tDCS and Its Therapeutic Effects in CK Fever
Status: COMPLETED
Conditions: Chikungunya Fever
Interventions: DEVICE: Transcranial Direct Current Stimulation|DEVICE: Sham Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Image Quality and Radiation Dose in Angiography
Status: COMPLETED
Conditions: Arteriovenous Malformations|Aneurysm|Stenosis|Dural Arteriovenous Malformations
Interventions: RADIATION: Low dose DSA (75% reduction compared to normal dose) with novel X-ray imaging technology.|RADIATION: Normal dose DSA with conventional X-ray technology
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Correlation Between Clinical Measurement Scales for Gross Motor Function
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: DIAGNOSTIC_TEST: Gross Motor Function Measurement - 66 (GMFM- 66)|DIAGNOSTIC_TEST: Bruininks- Oseretsky Motor Proficiency|DIAGNOSTIC_TEST: the Peabody Developmental Motor Scale - Second Edition (PDMS-2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Using Plain Water With Oral Care to Increase Hydration for Long Term Care Residents With Disordered Swallowing
Status: COMPLETED
Conditions: Dysphagia|Respiratory Tract Infections
Interventions: OTHER: FFWP and Improved Oral Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study for the Use of the IL-6 Inhibitor Clazakizumab in Patients With Life-threatening COVID-19 Infection
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Clazakizumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Polyphenon E in Addition to Erlotinib in Advanced Non Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Polyphenon E|DRUG: Tarceva
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clofarabine and Rituximab in Treating Patients With Relapsed Non-Hodgkin Lymphoma
Status: TERMINATED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: clofarabine|GENETIC: DNA methylation analysis|GENETIC: gene expression analysis|GENETIC: microarray analysis|GENETIC: polymerase chain reaction|OTHER: high performance liquid chromatography|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subcostal Transversus Abdominis Plane Versus Epidural Block in Abdominal Surgeries
Status: COMPLETED
Conditions: Upper Abdominal Surgery
Interventions: OTHER: Subcostal Transversus Abdominis Plane catheter|OTHER: Epidural catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE