pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Metformin IN Asthma for Overweight and Obese Individuals (MINA)
Status: NOT_YET_RECRUITING
Conditions: Asthma|Asthma Chronic|Overweight and Obesity
Interventions: DRUG: Metformin hydrochloride extended-release tablets|DRUG: Visually identical placebo Metformin hydrochloride extended-release tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TEAS for the Treatment of Pain in Bone Metastases of Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Cancer Pain|Non Small Cell Lung Cancer|Bone Metastases|Acupuncture
Interventions: DEVICE: Transcutaneous electrical acupoint stimulation|DEVICE: Sham transcutaneous electrical acupoint stimulation|DRUG: Routine palliative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Ranging, Pharmacokinetic (PK), Glucodynamic (GD), Safety and Tolerability Study of Subcutaneously (SC) Administered Humulin R and Humalog With or Without rHuPH20
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: rHuPH20|DRUG: Insulin Human Injection|DRUG: Insulin Lispro Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Topotecan and Gefitinib (Iressa) for Ovarian, Peritoneal, or Fallopian Tube Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Peritoneal Neoplasms|Fallopian Tube Cancer
Interventions: DRUG: Topotecan|DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcatheter Arterial Chemoembolization (TACE) in Combination With Arsenic Trioxide Versus TACE in the Treatment of Middle-advanced Primary Hepatocellular Carcinoma (HCC) Patients
Status: UNKNOWN
Conditions: Primary Hepatocellular Carcinoma
Interventions: DRUG: TACE|DRUG: Arsenic trioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AMIC Compared With Microfracture for Focal Articular Cartilage Damage of the Hip
Status: RECRUITING
Conditions: Hip Arthroscopy|Articular Cartilage Defect|Microfractures
Interventions: PROCEDURE: Autologous matrix-induced chondrogenesis (AMIC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive HCM Who Are Eligible for Septal Reduction Therapy
Status: COMPLETED
Conditions: HOCM, Hypertrophic Obstructive Cardiomyopathy
Interventions: DRUG: Mavacamten|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Global Controlled Trial on Effects of an Online Self-Help Program for of Ambitious Altruists on Their Mental Health, Wellbeing, and Productivity: Comparing Versions With IFS vs. CBT, Buddy- vs. Group-, Standard- vs. Minimum-Guidance Intensity.
Status: NOT_YET_RECRUITING
Conditions: Treatment Adherence and Compliance|Anxiety|Depression|Mental Health Issue|Quality of Life|Well-Being, Psychological|Social Functioning|Cognitive Dysfunction|Interpersonal Relations|Self Esteem|Loneliness|Functioning, Psychosocial|Functioning, Social
Interventions: BEHAVIORAL: guided online self-help program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Coblation-Tonsillotomy vs Electrocautery-Tonsillectomy for the Treatment of Obstructive Sleep Apnea (OSA) in Children
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea
Interventions: PROCEDURE: Electrocautery-tonsillectomy|PROCEDURE: Coblation-tonsillotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioma|Glioma of Brain|Cancer|Pediatric Cancer|Pediatric Brain Tumor|Astrocytoma|Glioblastoma|Hemispheric
Interventions: OTHER: Specialized tumor board recommendation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Positive End Expiratory Pressure on Central Venous Pressure Among Patients With Different Lung Compliance
Status: UNKNOWN
Conditions: Sepsis|ARDS|Traumatic Brain Injury
Interventions: OTHER: 5,10 and 15cmH2O positive end expiratory pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gastric Sleeve Pilot Study in Morbidly Obese Undergoing Liver Transplantation
Status: COMPLETED
Conditions: Obesity|Cardiovascular Disease|Type 2 Diabetes|Hypertension|Complication of Transplant
Interventions: PROCEDURE: Sleeve Gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Liraglutide in Healthy Male Volunteers
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: liraglutide|DRUG: liraglutide|DRUG: placebo|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BCG Modulation of the recMAGE-A3 + AS15 ASCI Response in the Treatment of Non Muscle Invasive Bladder Cancer (NMIBC) Patients
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: BIOLOGICAL: MAGE-A3 ASCI|BIOLOGICAL: BCG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Long-term Treatment of PINS Stimulator System for Patients With Obsessive-Compulsive Disorder
Status: UNKNOWN
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: Deep Brain Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)
Status: RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: ION363|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Blood and Tissue Samples From Patients With Locally Advanced, Metastatic, or Recurrent Non-Small Cell Lung Cancer Treated With Bevacizumab, Carboplatin, and Paclitaxel
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: carboplatin|DRUG: paclitaxel|GENETIC: gene expression analysis|GENETIC: polymerase chain reaction|GENETIC: polymorphism analysis|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of S-1 Plus Cisplatin (SP) Versus Gemcitabine Plus Cisplatin (GP) in Advanced Biliary Tract Adenocarcinoma
Status: COMPLETED
Conditions: Metastatic Biliary Cancer
Interventions: DRUG: S-1 plus cisplatin|DRUG: Gemcitabine plus Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stress Reactivity as a Determinant in Co-occurring Alcohol Use and Anxiety Disorder: Diagnosis and Alcohol Use Outcomes
Status: COMPLETED
Conditions: Alcohol Use Disorder|Anxiety Disorder/Anxiety State|Stress Disorder|Hypothalamic Pituitary Adrenal|Drinking to Cope
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Continuous GHRP-3 Infusion at on GH-IGF-I System, Blood Pressure, Glucose, and Insulin Resistance
Status: WITHDRAWN
Conditions: Insulin Resistance|Endothelial Dysfunction
Interventions: DRUG: GHRP-3 low dose|DRUG: GHRP-3 high dose|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Phase II Study of Ridaforolimus (MK-8669) With Metastatic Bone or Soft-tissue Sarcoma Patients (MK-8669-030 AM1)
Status: COMPLETED
Conditions: Sarcoma
Interventions: DRUG: Ridaforolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Titanium Prepared Platelet Rich Fibrin for Multiple Gingival Recessions
Status: COMPLETED
Conditions: Gingival Recession
Interventions: PROCEDURE: Root Coverage Surgery with T-PRF|PROCEDURE: Root Coverage Surgery with CTG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digital Intelligent Assistant for Nursing Application
Status: UNKNOWN
Conditions: Frailty Syndrome|Fall in Nursing Home|Dementia|Delirium in Old Age|Incontinence, Urinary|Incontinence Bowel
Interventions: DEVICE: Three dimensional sensor system designed for fall detection (Fearless)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Carnitine as an Adjunct to Methylphenidate for the Treatment of Attention Deficit Hyperactivity Disorder
Status: UNKNOWN
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Methylphenidate+placebo|DRUG: methylphenidate+carnitine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Resilience for Older Workers With OA Through Exercise
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Osteoarthritis, Hip
Interventions: OTHER: Exercise|OTHER: No Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Beauty as a State of Wellness Beauty as a State of Wellbeing in Women 40 to 64 Years of Age
Status: COMPLETED
Conditions: Self Esteem|Psychological Well-being|Stress, Physiological|Mood
Interventions: OTHER: Positive reinforcement method|OTHER: Standard method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Influence of a Cognitive Behavioral Approach on Changing Patient Expectations in Shoulder Pain
Status: COMPLETED
Conditions: Rotator Cuff Impingement Syndrome|Rotator Cuff Injury|Shoulder Pain
Interventions: BEHAVIORAL: Patient Engagement Education and Restructuring of Cognitions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of SHR-1501 Combined With SHR-1316 in Patients With Advanced Tumors
Status: COMPLETED
Conditions: Advanced Malignancies
Interventions: DRUG: SHR-1501|DRUG: SHR-1316
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics and Clinical Activity of RO6870810 and Atezolizumab (PD-L1 Antibody) in Participants With Advanced Ovarian Cancer or Triple Negative Breast Cancer
Status: TERMINATED
Conditions: Advanced Ovarian Cancer|Triple Negative Breast Cancer
Interventions: DRUG: Atezolizumab|DRUG: RO6870810
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modified Thoracoabdominal Nerve Plane Block In Living Liver Donors
Status: RECRUITING
Conditions: Liver Failure|Acute Postoperative Pain
Interventions: PROCEDURE: M-TAPA plane block|PROCEDURE: Postoperative pain management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DASH Cloud: Using Digital Health to Improve Adherence to the DASH Diet Among Women
Status: COMPLETED
Conditions: Diet Modification|Hypertension|Women's Health|Cardiovascular Diseases|Digital Health
Interventions: OTHER: DASH Cloud|OTHER: Nutritionix Track app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transabdominal US-guided (UGET) vs. Modified Transvaginal US-guided (mTVET) Embryo Transfer in Human IVF
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: ET under transabdominal US guidance (UGET)|PROCEDURE: ET after transvaginal US uterine measurement (mTVET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Process and Effect Evaluation of the KickAsh! Intervention
Status: ACTIVE_NOT_RECRUITING
Conditions: Smoking Cigarette|Smoking Tobacco|Smoking|Smoking Prevention
Interventions: BEHAVIORAL: KickAsh! intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: LITT and Pembrolizumab in Recurrent Brain Metastasis
Status: TERMINATED
Conditions: Melanoma|Non-small Cell Lung Carcinoma (NSCLC)|Renal Cell Carcinoma (RCC)|Small-cell Lung Cancer|Head and Neck Squamous Cell Cancer|Classical Hodgkin Lymphoma|Primary Mediastinal Large B-Cell Lymphoma|Urothelial Carcinoma|Microsatellite Instability-High Cancer|Gastric Cancer|Esophageal Cancer|Cervical Cancer|Hepatocellular Carcinoma|Merkel Cell Carcinoma|Brain Metastases, Adult
Interventions: COMBINATION_PRODUCT: LITT + Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment in Patients With Essential Trigeminal Neuralgia of Nerve Involvement by MRI in DTI and Functional Connectivity in "Resting State"
Status: RECRUITING
Conditions: Trigeminal Neuralgia|Microvascular Decompression Surgery|Diffusion Tensor Imaging
Interventions: PROCEDURE: Assessment of the trigeminal nerve by diffusion tensor MRI and in "resting state" in the context of essential neuralgia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Study of Recombinant Human Follitropin for Injection Assisted in COH Assisted IVF-ET
Status: UNKNOWN
Conditions: Ovarian Hyperstimulation Syndrome
Interventions: DRUG: Triptorelin for Injection|DRUG: Recombinant Human Choriogonadotropin alfa Solution for Injection|DRUG: Progesterone Soft Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Inguinodynia After Inguinal Hernia Repair
Status: COMPLETED
Conditions: Inguinal Hernia|Inguinal Hernia Repair|Open Inguinal Hernia
Interventions: PROCEDURE: HERNIOPLASTY WITH PANAVALE MESH|PROCEDURE: HERNIOPLASTY WITH PARIETEX PROGRIP MESH|PROCEDURE: HERNIOPLASTY WITH ADHESIX MESH|PROCEDURE: HERNIOPLASTY WITH TIMESH MESH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Iguratimod Combined With Tofacitab in Patients With RF Positive/Negative Rheumatoid Arthritis
Status: RECRUITING
Conditions: Rheumatoid Arthritis|Therapy
Interventions: DRUG: Iguratimod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Potent Inducer Rifampicin on the Pharmacokinetics of Deferasirox in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Deferasirox|DRUG: Rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Comparison Effectiveness of Oral Ivermectin , 1% Permethrin Shampoo and 4% Dimeticone Liquid Gel in the Treatment of Pediculosis Capitis Among School Children in Chachoengsao Province, Thailand
Status: ACTIVE_NOT_RECRUITING
Conditions: Pediculus Capitis Infestation|Permethrin Adverse Reaction|Dimethicone Adverse Reaction|Permethrin Allergy|Dimethicone Allergy|Ivermectin|School-age Children
Interventions: DRUG: Oral Ivermectin|DRUG: 4% dimenticone liquid gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treating Chronic Insomnia in Breast Cancer Patients
Status: TERMINATED
Conditions: Chronic Insomnia
Interventions: DRUG: Placebo|DRUG: Ramelteon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Project Hypnos: The Impact of a Brief Hypnosis Intervention on Single-limb Dynamic Balance in People With Chronic Ankle Instability
Status: COMPLETED
Conditions: Ankle Sprains|Motor Coordination or Function; Developmental Disorder
Interventions: BEHAVIORAL: Self-Hypnosis|BEHAVIORAL: Ankle Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Buerger Allen Exercise Among Type 2 Diabetes Mellitus Patients With Foot Ulcer
Status: COMPLETED
Conditions: Diabetic Foot Ulcers
Interventions: BEHAVIORAL: Buerger Allen Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Towards a Food Ingredient Clinically Proven to Benefit Gut Health: Novel RG-I Variants
Status: RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Maltodextrin|DIETARY_SUPPLEMENT: Chicory RG-I|DIETARY_SUPPLEMENT: Carrot RG-I
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: LIVE-C-Free: Early and Late Treatment of Hepatitis C With Sofosbuvir/Ledipasvir in Liver Transplant Recipients
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Sofosbuvir/Ledipasvir x 12 weeks|DRUG: Sofosbuvir/Ledipasvir + Ribavirin x 12 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperpolarized Carbon 13-Based Metabolic Imaging to Detect Radiation-Induced Cardiotoxicity
Status: RECRUITING
Conditions: Thoracic Cancer|Left Sided Breast Cancer
Interventions: DIAGNOSTIC_TEST: [1-13C]pyruvate along with MRI imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dietary Counselling Plus Omega-3 Supplementation in the Treatment of Generalized Anxiety Disorder
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: COMBINATION_PRODUCT: Dietary Counselling combined with Omega-3 Supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Regulatory Post Marketing Surveillance (rPMS) Study of Ozempic (Semaglutide) to Evaluate Safety and Effectiveness in Patients With Type 2 Diabetes Mellitus in Routine Clinical Practice in Korea
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Comparing Remimazolam Tosilate and Propofol for Intravenous General Anaesthesia in Operations
Status: COMPLETED
Conditions: General Anesthesia
Interventions: DRUG: Remimazolam Tosilate|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Quantification of Dynamic and Static Cerebral Autoregulation (CA) Under Anaesthesia
Status: COMPLETED
Conditions: Cerebrovascular Circulation
Interventions: DRUG: Phenylephrine infusion|OTHER: Mechanical ventilation|DRUG: Propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: T-Cell PET Imaging With [18F]F-AraG in Lung Cancer
Status: WITHDRAWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: [18F]F-Ara-G|DRUG: Pembrolizumab|RADIATION: PET/CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of an Anti-Smoking Mobile Application on Self-Efficacy, Decision Making and Breath Carbon Monoxide Levels
Status: NOT_YET_RECRUITING
Conditions: Smoking|Mobile Application
Interventions: OTHER: experimental group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Testing the REThinkACADEMY Interventions in Prevention of Emotional Disorders in College Students.
Status: ACTIVE_NOT_RECRUITING
Conditions: Emotion Regulation|Stress
Interventions: BEHAVIORAL: REThink Life Game|BEHAVIORAL: PsyPills|BEHAVIORAL: MoodWheel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Granulocytapheresis in Psoriasis
Status: TERMINATED
Conditions: Psoriasis
Interventions: DEVICE: Treatment with a Granulocyte Adsorber, Medica Adsorber 1.1|DEVICE: Treatment with a sham device, EXcorLab box 1.2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Less Invasive AV Fistula for Vascular Access in ESRD
Status: COMPLETED
Conditions: End Stage Renal Disease|AV Fistula|Fistula|End Stage Kidney Disease
Interventions: DEVICE: Ellipsys Vascular Access Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study of LBVH0101 in Healthy Infants at Two, Four and Six Months of Age
Status: COMPLETED
Conditions: Infectious Disease by Haemophilus Influenzae Type b
Interventions: BIOLOGICAL: LBVH0101 (Hib vaccine)|BIOLOGICAL: Hiberix™ Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Repeated Whole Brain Radiotherapy Versus Best Supportive Care for Multiple Brain Metastases.
Status: UNKNOWN
Conditions: Brain Metastasases
Interventions: RADIATION: Whole Brain Radiotherapy|OTHER: Best Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Boron Neutron Capture Therapy in Treating Patients With Glioblastoma Multiforme or Melanoma Metastatic to the Brain
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Melanoma (Skin)|Metastatic Cancer
Interventions: DRUG: boronophenylalanine-fructose complex
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Preoperative Sequential Short-course Radiation Therapy and FOLFOX for Locally Advanced Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer
Interventions: RADIATION: short-course radiotherapy|DRUG: mFOLFOX6|RADIATION: Chemoradiotherapy|PROCEDURE: TME surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-amylose Barley (HIAMBA) in the Regulation and Prevention of Type 2 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: 100% wheat (control)|DIETARY_SUPPLEMENT: 100% Lean-baking barley®|DIETARY_SUPPLEMENT: 100% regular barley
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: REBECCA Study (RadiothErapy for BrEast Cancer and CArdiotoxicity)
Status: WITHDRAWN
Conditions: Toxicity Due to Radiotherapy|Breast Cancer|Lesion; Cardiac
Interventions: OTHER: Helical tomotherapy for breast cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ultrasound-guided Nerve Blocks for the Sciatic and Saphenous Nerves: Characteristics of the Single Penetration Dual Injection (SPEDI) Technique
Status: COMPLETED
Conditions: Lower Leg Surgery, e.g. Ankle Fractures
Interventions: PROCEDURE: Single penetration dual injection (SPEDI) block technique to block the sciatic and the saphenous nerve with one needle penetration of the skin|PROCEDURE: The classical popliteal sciatic nerve block combined with the mid-femoral saphenous nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Disseminated Tumour Cells (DTC) in Left Sided Colorectal Cancer (LSCC).
Status: COMPLETED
Conditions: Colorectal Cancer|Bone Marrow Tumor Cell Infiltration
Interventions: DIAGNOSTIC_TEST: Bone marrow analysis to identify disseminated tumour cells
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Efficacy of Tamsulosin and Tadalafil Compared to Placebo in the Treatment and Prevention of Urinary Disorders After Transperineal Prostate Biopsy
Status: ENROLLING_BY_INVITATION
Conditions: Lower Urinary Tract Symptoms|Voiding Disorders|Pain|Quality of Life
Interventions: DRUG: Tadalafil 5mg|DRUG: Tamsulosin Hydrochloride 400 Microgram Prolonged-Release Oral Capsule|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Prevention of Bone-related Events in Patients With Bone Metastases From Malignant Solid Tumors Treated With JMT103 Compared to Zoledronic Acid
Status: NOT_YET_RECRUITING
Conditions: Imaging Examination Shows at Least One Site With Bone Metastases From Soild Tumors
Interventions: DRUG: JMT103|DRUG: zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Leflunomide for the Treatment of Severe COVID-19 in Patients With a Concurrent Malignancy
Status: COMPLETED
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm|Symptomatic COVID-19 Infection Laboratory-Confirmed
Interventions: OTHER: Best Practice|DRUG: Leflunomide|DRUG: Placebo Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Left Atrial Septostomy Versus Conventional Approach After Venoarterial Extracorporeal Membrane Oxygenation
Status: COMPLETED
Conditions: Cardiogenic Shock
Interventions: PROCEDURE: Early left atrial septostomy within 12 hours after VA-ECMO implantation|PROCEDURE: Selective left atrial septostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of GP30101 800 mg (GEROPHARM) Versus PREZISTA® 800 mg ("Jonson&Jonson", Russia)
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: GP30101|DRUG: Prezista®|DRUG: GP30101|DRUG: Prezista®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)
Status: RECRUITING
Conditions: Advanced Non-small Cell Lung Cancer|EGFR Mutation|HER2 Mutation
Interventions: DRUG: BAY2927088_formulation A|DRUG: BAY2927088_formulation B_1|DRUG: BAY2927088_formulation B_2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Predictive Role of Urinary Proteomics in Blood Pressure Response of Obese Hypertensive Treated With Irbesartan or Eplerenone.
Status: RECRUITING
Conditions: Primary Hypertension|Obesity
Interventions: DRUG: Irbesartan 150mg|DRUG: Eplerenone 25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Technical Accuracy and Userfriendliness of Two Point-of-care C Reactive Protein Devices in Comparison With Laboratory CRP Testing.
Status: COMPLETED
Conditions: Healthy and Acutely Ill Children & Adults
Interventions: DEVICE: Point-of-Care C Reactive Protein measurement on capillary blood
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Safety/Tolerability, Pharmacokinetics, and Pharmacodynamics After Intravenous DWJ1521 Administration in Healthy Adult Volunteers
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: Normal saline|DRUG: DWJ1521|DRUG: DWP14012 Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fasting Study of Olanzapine Tablets 20 mg and Zyprexa® Tablets 20 mg
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: Olanzapine Tablets 20 mg|DRUG: Zyprexa® Tablets 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of Elidel Cream on Erosive Oral Lichen Planus
Status: COMPLETED
Conditions: Lichen Planus, Oral
Interventions: DRUG: Pimecrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine and Swallowing Function
Status: UNKNOWN
Conditions: Deglutition
Interventions: DRUG: Placebo|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Disclosing Dental Plaque on Plaque Index and Gingival Index in Faculty of Dentistry Students
Status: ENROLLING_BY_INVITATION
Conditions: Periodontal Indexes|Oral Health
Interventions: OTHER: Experimental: Group 1 (dental examination-training-tooth brushing) Experimental: Group 2 (dental examination-training-plaque disclosing-tooth brushing)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: gemcitabine hydrochloride|DRUG: pegylated liposomal doxorubicin hydrochloride|DRUG: vinorelbine ditartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subject Variability in Two Lots of E5501 Administered to Fed and Fasted Healthy Subjects
Status: COMPLETED
Conditions: Purpura, Thrombocytopenic, Idiopathic|Acute Idiopathic Thrombocytopenic Purpura|Chronic Thrombocytopenia
Interventions: DRUG: E5501 40 mg 2 x 20-mg tablets, orally, fasted|DRUG: E5501 40 mg 2 x 20-mg tablets, orally, with food|DRUG: E5501 40mg 2 x 20-mg tablets, orally, fasted|DRUG: E5501 40 mg 2 x 20-mg tablets, orally, with food
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Insertion Clinical Study to Evaluate the Aberration Characteristics of Kalifilcon A Toric Lenses
Status: COMPLETED
Conditions: Contact Lens Wearer
Interventions: DEVICE: kalifilcon A Daily Disposable Toric LD213001 lens in SKUs +6D, +3D, 0D, -3D, -6D, and -9D
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Randomized, Double-Blind, Placebo-Controlled Study of Intravenous Immune Globulin for Chronic Inflammatory Demyelinating Polyneuropathy
Status: COMPLETED
Conditions: Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Interventions: DRUG: Immune globulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Lafullen15 and Lafullen for Temporary Nasolabial Fold Improvement
Status: NOT_YET_RECRUITING
Conditions: Nasolabial Folds
Interventions: DEVICE: Lafullen15|DEVICE: Lafullen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MRI - Guided Adaptive RadioTHerapy for Reducing XerostomiA in Head and Neck Cancer (MARTHA-trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer|Xerostomia Due to Radiotherapy
Interventions: OTHER: Pre-defined MR-linac based IGRT and plan adaptation protocol|DIAGNOSTIC_TEST: salivary flow measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trunk Oriented Exercises Versus Whole-body Vibration for Duchenne Muscular Dystrophy
Status: COMPLETED
Conditions: Muscular Dystrophy, Duchenne Type
Interventions: OTHER: trunk oriented exercise|OTHER: whole body vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Abdominal Muscles Recovery Response to Kinesiotaping in Women With Postnatal Diastasis
Status: UNKNOWN
Conditions: Diastasis Recti
Interventions: OTHER: Kinesiotaping|OTHER: Abdominal Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Processing Therapy Versus Prolonged Exposure for Treating Women With Post-Traumatic Stress Disorder Brought on by Sexual Assault
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: BEHAVIORAL: Cognitive Processing Therapy|BEHAVIORAL: Prolonged Exposure Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Loteprednol Etabonate Versus Vehicle for the Treatment of Inflammation and Pain Following Cataract Surgery
Status: COMPLETED
Conditions: Inflammation|Pain
Interventions: DRUG: Loteprednol etabonate|DRUG: Vehicle of Loteprednol Etabonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Whole Grain Job's Tear, Muscle Health, Blood Glucose and Lipid Level
Status: RECRUITING
Conditions: Sarcopenia|Frailty|Hyperglycemia|Hyperlipidemia
Interventions: BIOLOGICAL: Taiwanese whole grain job's tear (red job's tear)|BIOLOGICAL: White job's tear
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Multimodal Analgesia in Abdominal Hysterectomy
Status: UNKNOWN
Conditions: Planned Abdominal Hysterectomy
Interventions: DRUG: Gabapentin|DRUG: Lidocaine|DRUG: S-ketamine|PROCEDURE: Epidural analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The RAS, Fibrinolysis and Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Coronary Artery Disease|Angiotensin Converting Enzyme|Angiotensin Receptor Blockers|Cardiopulmonary Bypass|Fibrinolysis|Inflammation
Interventions: DRUG: Placebo|DRUG: Ramipril|DRUG: Candesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sm-TSP-2 Schistosomiasis Vaccine in Healthy Ugandan Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Schistosomiasis|Schistosoma Mansoni
Interventions: BIOLOGICAL: Sm-TSP-2/Alhydrogel® vaccine|BIOLOGICAL: Sm-TSP-2/Alhydrogel® vaccine plus AP 10-701|BIOLOGICAL: ENGERIX-B Hepatitis B Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: STA-9090 for Treatment of AML, CML, MDS and Myeloproliferative Disorders
Status: COMPLETED
Conditions: AML|CML|MDS|Myeloproliferative Disorders
Interventions: DRUG: STA-9090 (ganetespib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vorinostat in Treating Patients With Stage IV Breast Cancer Receiving Aromatase Inhibitor Therapy
Status: COMPLETED
Conditions: Male Breast Cancer|Recurrent Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: vorinostat|OTHER: laboratory biomarker analysis|PROCEDURE: biopsy|RADIATION: F-18 16 alpha-fluoroestradiol|PROCEDURE: positron emission tomography|DRUG: anastrozole|DRUG: letrozole|DRUG: exemestane|GENETIC: gene expression analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Hancock Jaffe Surgical Antireflux Venous Valve Endoprosthesis Study
Status: RECRUITING
Conditions: Deep Venous Insufficiency (Diagnosis)
Interventions: DEVICE: Hancock-Jaffe bioprosthetic venous valve (VenoValve®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effects of Heated Humidification During Non-Invasive Ventilation
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Chronic Respiratory Hypercapnic Failure|Neuromuscular Disease|Obesity Hypoventilation Syndrome
Interventions: DEVICE: non-invasive ventilation heated humidification (Fisher-Paykel MR810 and MR850 humidifiers)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EndovaSCular TreAtment to imProve outcomEs for Medium Vessel Occlusions (ESCAPE-MeVO Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DEVICE: endovascular thrombectomy (EVT)|OTHER: Standarad medical care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of NXL103 Versus Comparator in Adults With Community Acquired Pneumonia
Status: COMPLETED
Conditions: Community Acquired Pneumonia
Interventions: DRUG: NXL103|DRUG: comparator|DRUG: NXL103
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating Central Neurophysiologic Correlates of Non-Motor Symptoms of Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease|Autonomic Dysfunction|Depression
Interventions: DEVICE: transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nasal Mucin Oral Supplementation Treatment Respiratory Inflammation Using PUFA in Cystic Fibrosis (CF) Patients
Status: TERMINATED
Conditions: Cystic Fibrosis|Dietary Modification
Interventions: OTHER: polyunsaturated fatty acids n-3|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Comparing 5% Monoxidil Milky Lotion Versus 5% Minoxidil Solution in Androgenetic Alopecia
Status: UNKNOWN
Conditions: Objective (Goal)|Self-Assessment|Adverse Effects
Interventions: DRUG: 5% MInoxidil milky lotion|DRUG: 5% Minoxidil solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pulmonart: Docetaxel - Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Lung Neoplasms
Interventions: DRUG: docetaxel and cisplatin followed by concurrent chemoradiotherapy with docetaxel and cisplatin + radiotherapy|DRUG: docetaxel and cisplatin + radiotherapy followed by docetaxel and cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: INtranasal OXyTocin for the Treatment of Autism Spectrum Disorders
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Intranasal Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AIDMA: A Psycho-educational Program Designed to Support and Train Carers of Alzheimer's Disease (AD) Patients
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: BEHAVIORAL: Controlled diet|BEHAVIORAL: Self-hypnotic relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparative Effects of Dual Task and PNF on Balance ,Cognition and Motor Function in Chronic Stroke Patients .
Status: RECRUITING
Conditions: Stroke
Interventions: OTHER: Dual tasking|OTHER: PNF(proprioceptive neuromuscular facilitation exercises)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Serving Size and Addition of Sugar on the Glycemic Response Elicited by Oatmeal
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: OTHER: Classic Quaker Quick Oats|OTHER: Cream of Rice Cereal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The LUTEAL Trial: Luteal Stimulation vs. Estrogen Priming Protocol
Status: RECRUITING
Conditions: Infertility|Diminished Ovarian Reserve|IVF
Interventions: PROCEDURE: Timing of injectable gonadotropins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Conversion of Candonilimab (AK104) Plus Paclitaxel, S-1 and Apatinib for Unresectable Advanced G/GEJ Cancer
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: AK104|DRUG: Apatinib|DRUG: Paclitaxel|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnesium Sulphate in Perinatal Asphyxia
Status: COMPLETED
Conditions: Perinatal Asphyxia , Moderate to Severe HIE
Interventions: DRUG: Magnesium sulphate|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect and Safety of Electroacupuncture for Symptoms of Menopausal Transition
Status: COMPLETED
Conditions: Menopausal Syndrome
Interventions: OTHER: electroacupuncture|OTHER: sham electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: STAAR-1 Clinical Study
Status: COMPLETED
Conditions: Chronic Kidney Disease|Chronic Renal Insufficiency|Kidney Disease|Pre-dialysis|Pre-ESRD
Interventions: DRUG: darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotic Saccharomyces Boulardii for the Prevention of Antibiotic-associated Diarrhoea
Status: TERMINATED
Conditions: Antibiotic-associated Diarrhea|Clostridium Difficile|Diarrhea
Interventions: DRUG: Saccharomyces boulardii|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: "Cognitive Rehabilitation With Direct Current Transcranial Stimulation in Post-Traumatic Brain Injury Patients"
Status: RECRUITING
Conditions: Traumatic Brain Injury|Cognitive Impairment
Interventions: DEVICE: Cognitive Computerized Training (CCT) plus Anodic transcranial Direct Current Stimulation (tDCS)|DEVICE: Cognitive Computerized Training (CCT) plus sham transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Rifaximin on Gut Bacterial Flora Post Stem Cell Transplant in Patients With Acute Leukemia
Status: NOT_YET_RECRUITING
Conditions: Acute Leukemia
Interventions: DRUG: Rifaximin with allogeneic stem cell transplant|PROCEDURE: Allogeneic stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT