pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Acute Effects of LBBP Versus BVP for CRT
Status: COMPLETED
Conditions: Heart Failure|Cardiac Pacing, Artificial|Cardiac Resynchronization Therapy
Interventions: PROCEDURE: left bundle branch pacing|PROCEDURE: biventricular pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study of the Tolerability of Two Combination Therapies for the Treatment of Acne
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: BENZOYL PEROXIDE/ CLINDAMYCIN|DRUG: BENZOYL PEROXIDE/ ADAPALENE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pelvic Floor Reconstruction Using Biological Mesh With Negative Pressure Wound Therapy Following ELAPE
Status: UNKNOWN
Conditions: Perineal Wound Complications After ELAPE
Interventions: PROCEDURE: Negative Pressure Wound Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CONcurrent vs SEqueNTial Adjuvant Treatments in Early Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Anastrozole or Letrozole or Exemestane|DRUG: Anastrozole or Letrozole or Exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral Appliance Therapy on Glucose Levels in Patients With T2DM and OSA: A Pilot Trial
Status: UNKNOWN
Conditions: Sleep Apnea, Obstructive|Type 2 Diabetes Mellitus
Interventions: DEVICE: Oral appliance therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proposal of a Method Using the PMSI and SNIIRAM National Databases to Estimate the Frequency of Physical Abuse and to Identify th Eassociated At-risk Situations and Consequences in Children Aged 0 to 5 Years in France
Status: COMPLETED
Conditions: Child Abuse
Interventions: OTHER: ICD-10
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Delayed Cord Clamping in Preterm Neonates
Status: COMPLETED
Conditions: Premature Birth of Newborn|Infant, Very Low Birth Weight|Delayed Separation of Umbilical Cord|Placental Transfusion
Interventions: OTHER: 30 Seconds of placental blood transfusion|OTHER: 60 Seconds of placental blood transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of MBX 1416 in Healthy Subjects
Status: RECRUITING
Conditions: Postbariatric Hypoglycemia
Interventions: DRUG: MBX 1416 (Part A)|DRUG: MBX 1416 (Part B)|DRUG: Placebo|DRUG: MBX 1416 (Part C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Safety and Pharmacology Of PI3-Kinase Inhibitor GDC-0941 In Combination With Either Paclitaxel And Carboplatin (With or Without Bevacizumab) or Pemetrexed, Cisplatin, And Bevacizumab in Patients With Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: GDC-0941|DRUG: bevacizumab|DRUG: carboplatin|DRUG: cisplatin|DRUG: paclitaxel|DRUG: pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beneficial Effects of Mindfulness-based Training on Neuropsychological Outcomes in Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Mindfulness Based Training (MBT) Program|BEHAVIORAL: Cognitive Rehabilitation Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AMblyopia Treatment Through PErceptual Training in Children (AMPEL)
Status: WITHDRAWN
Conditions: Strabismic Amblyopia
Interventions: OTHER: crowded drawing task|OTHER: uncrowded drawing task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: visuALL Field Analyzer (vFA) Compared to Standard Humphrey Automated Perimetry
Status: COMPLETED
Conditions: Glaucoma, Open-Angle
Interventions: DIAGNOSTIC_TEST: Standard Automatic Perimetry Humphrey Field Analyzer|DIAGNOSTIC_TEST: visuALL Field Analyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Red Grape Cells (RGC) Powder Consumption on Measures of Aerobic Fitness and Mood
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: RGC|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Transarterial Chemoembolization (TACE) Therapy of Hepatocellular Carcinoma (HCC) With Blocking Tumor Blood Temporarily and Enhancing Perfusion
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: balloon catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Life Care Specialists (LCS) With a Focus on Patient Pain Management and Prevention of Substance Misuse
Status: COMPLETED
Conditions: Opioid Use
Interventions: BEHAVIORAL: Pain Management Strategies|BEHAVIORAL: Life Care Specialist (LCS) Intervention|OTHER: Clinical Coordination with Referrals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Chronic Total Occlusion Crossing With the Wildcat Catheter
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: Chronic TOtAl OcclusioN CrossiNg with thE WildCat CatheTer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Growth and Tolerance of Healthy Term Infants Fed Iron-Fortified Infant Formulas
Status: RECRUITING
Conditions: Infant Development
Interventions: OTHER: Infant Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study Of Inotuzumab Ozogamicin Versus Investigator's Choice Of Chemotherapy In Patients With Relapsed Or Refractory Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: inotuzumab ozogamicin|DRUG: FLAG (fludarabine, cytarabine and G-CSF)|DRUG: HIDAC (high dose cytarabine)|DRUG: cytarabine and mitoxantrone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Norwalk Vaccine Study
Status: COMPLETED
Conditions: Acute Gastroenteritis|Norwalk Virus Infection
Interventions: BIOLOGICAL: Norwalk VLP vaccine|BIOLOGICAL: mannitol and sucrose|BIOLOGICAL: Norwalk virus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase III Randomized Study of Ursodiol With Vs Without Methotrexate for Primary Biliary Cirrhosis
Status: COMPLETED
Conditions: Liver Cirrhosis, Biliary
Interventions: DRUG: methotrexate|DRUG: ursodiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and PerSiStence With IBD Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Inflammatory Bowel Diseases|Crohn Disease|Ulcerative Colitis
Interventions: BEHAVIORAL: Remote monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of BI 1356 in Combination With Metformin in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo identical to BI 1356 5mg|DRUG: Placebo identical to Glimepiride 1mg or 2mg or 3mg or 4 mg|DRUG: BI 1356|DRUG: Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Oregovomab and PLD in PARP Inhibitor Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Patients Not Candidate for Platinum Retreatment
Status: RECRUITING
Conditions: PARP Inhibitor Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Patients Not Candidate for Platinum Retreatment
Interventions: DRUG: Orevogomab+PLD|DRUG: Orevogomab+Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project to Improve Communication About Serious Illness--Hospital Study: Pragmatic Trial (Trial 1)
Status: COMPLETED
Conditions: Dementia|Chronic Disease|Neoplasm Metastasis|Lung Neoplasm|Pulmonary Disease, Chronic Obstructive|Heart Failure，Congestive|Liver Cirrhosis|Kidney Failure, Chronic|Lung Diseases, Interstitial|Peripheral Vascular Disease|Diabetes With End Organ Injury|Palliative Care, Patient Care|Health Care Quality, Access, and Evaluation|Patient Care|Inpatients|Health Communication|Patient Care Planning
Interventions: BEHAVIORAL: EHR-based Clinician Jumpstart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Chewing Gum With CPP-ACP on Tooth Mineralisation in Situ
Status: UNKNOWN
Conditions: Tooth Demineralization
Interventions: OTHER: Sugar free gum without CPP-ACP|OTHER: Sugar free gum with CPP-ACP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Use of an Absorbable Coated Suture Material in Surgery (Safil)
Status: COMPLETED
Conditions: Gastrointestinal Diseases|Laparotomy|Anastomosis, Surgical|Absorbable, Coated Sutures
Interventions: PROCEDURE: Gastrointestinal Anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: One-stage Breast Reconstruction Using Dermal Matrix/Implant Versus Two-stage Expander/Implant Procedure
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: One-stage dermal matrix/implant procedure|PROCEDURE: Two-stage tissue expander/implant procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impella ECP Study (ECP Study) and Impella ECP Continued Access Protocol
Status: ENROLLING_BY_INVITATION
Conditions: High-Risk Percutaneous Coronary Intervention
Interventions: DEVICE: Impella ECP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing ARB With Radium-223 vs ARB Therapy With Placebo and the Effect Upon Survival for mCRPC Patients
Status: TERMINATED
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: Enzalutamide during Lead-in Period|DRUG: Lead-in Enzalutamide followed by Radium-223/Enzalutamide|DRUG: Lead-in Enzalutamide followed by Placebo/Enzalutamide|DRUG: Darolutamide during Lead-in Period|DRUG: Lead-in Darolutamide followed by Radium-223/Darolutamide|DRUG: Lead-in Darolutamide followed by Placebo/Darolutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Impact of LIve Music in the Intensive Care Unit (ICU) to Improve Care for Critically Ill Patients
Status: ENROLLING_BY_INVITATION
Conditions: Anxiety|Pain|Critical Illness|Relaxation
Interventions: BEHAVIORAL: Therapeutic Music Session
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Therapeutic Monitoring of Drugs Used in the Treatment of Multiple Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis
Interventions: DIAGNOSTIC_TEST: Measurement of concentrations of orally-used DMDs|DIAGNOSTIC_TEST: Genetic testing|DIAGNOSTIC_TEST: Parameters for routine use of DMDs|OTHER: Side effects of orally used DMDs
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: GP Extended Action Triptorelin
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Decapeptyl® SR 22.5mg|DRUG: Decapeptyl® SR 11.25mg; Prostap® 3 DCS 11.25mg; Zoladex® LA 10.8mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dupilumab in the Treatment of Severe Uncontrolled CRSwNP: a Multicentre Observational Real-life Study (DUPIREAL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Rhinosinusitis With Nasal Polyps
Interventions: DRUG: Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT]
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Samuraciclib in Combination With Fulvestrant in Metastatic or Locally Advanced Breast Cancer in Adult Participants
Status: RECRUITING
Conditions: Metastatic Breast Cancer|Locally Advanced Breast Cancer|Breast Cancer
Interventions: DRUG: Samuraciclib|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Biofeedback on Osseous Union Using Pedobarography After Mid- and Hindfoot Arthrodesis
Status: RECRUITING
Conditions: Complication of Surgical or Medical Care
Interventions: DEVICE: Smartsens, Gelenic AG; with biofeedback|DEVICE: Smartsens, Gelenic AG; without biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pegasys VR: Integrating Virtual Humans in the Treatment of Child Social Anxiety
Status: COMPLETED
Conditions: Anxiety Disorders
Interventions: BEHAVIORAL: Pegasys-VR|BEHAVIORAL: Social Effectiveness Therapy for Children
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improvement of Short Term Outcome of Mild to Moderate Atopic Dermatitis Using a Combination of Crisaborole and a Concomitant Topical Corticosteroid Over a 8 Week Period
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Crisaborole 2% Topical Application Ointment [EUCRISA]|DRUG: Triamcinolone Acetonide 0.1% Ointment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Genetic Variation in Organic Cation Transport 1 (OCT1) and Its Significance for Morphine Pharmacokinetics
Status: COMPLETED
Conditions: Organic Cation Transporter 1|Morphine
Interventions: DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase 1 Study of Osilodrostat (LCI699) in Healthy Volunteers and Subjects With Impaired Hepatic Function
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: osilodrostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability and Pharmacokinetics of RO6889678 and the Combination of RO6889678 With Ritonavir in Healthy Participants
Status: TERMINATED
Conditions: Healthy Volunteer
Interventions: DRUG: Placebo|DRUG: RO6889678|DRUG: Midazolam|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Cinacalcet HCl in Chronic Kidney Disease Subjects With Secondary Hyperparathyroidism Not Receiving Dialysis
Status: COMPLETED
Conditions: Kidney Disease|Chronic Kidney Disease
Interventions: DRUG: Cinacalcet HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Intra-operative Radiotherapy With Post-operative Radiotherapy for Women With Early Breast Cancer
Status: COMPLETED
Conditions: Invasive Breast Cancer|Breast Cancer
Interventions: DEVICE: Intrabeam|RADIATION: Post-operative radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of an Environmental Health Education Program on Pregnant Women in Order to Reduce Endocrine Disruptor Exposition
Status: COMPLETED
Conditions: Pregnancy|Endocrine System|Prevention Program
Interventions: BEHAVIORAL: sensibilisation program "Ma maison, mon environnement santé"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A 48 Week Study Comparing Treatment With Saquinavir + Lopinavir/Ritonavir in Combination With Enfuvirtide HAART Versus Saquinavir + Lopinavir/Ritonavir + Other Nucleoside Combinations to See the Efficacy of These Treatments in Patients Infected With HIV-1
Status: TERMINATED
Conditions: HIV Infection
Interventions: DRUG: FUZEON [enfuvirtide]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of Merestinib (LY2801653) in Japanese Participants With Advanced or Metastatic Cancer
Status: COMPLETED
Conditions: Advanced Cancer|Metastatic Cancer|Biliary Tract Carcinoma|Cholangiocarcinoma|Gall Bladder Carcinoma|Solid Tumor|Non-Hodgkin's Lymphoma
Interventions: DRUG: Merestinib|DRUG: Cisplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Systemic Effects of A Continuous Blood Flow Restricted Aerobic Exercise Session in COPD Patients: A Randomised Controlled Trial.
Status: ENROLLING_BY_INVITATION
Conditions: COPD
Interventions: PROCEDURE: aerobic exercise with blood flow restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Emotional Working Memory Training on Preventing Depression Occurrence
Status: UNKNOWN
Conditions: Depressive Symptoms
Interventions: BEHAVIORAL: maintaining positive working memory training|BEHAVIORAL: repressing negative working memory training|BEHAVIORAL: Positive ABMT|BEHAVIORAL: Positive placebo ABMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Methotrexate and Glucocorticoids in Treating Patients With Newly Diagnosed Acute Graft-Versus-Host Disease After Donor Stem Cell Transplant
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: methotrexate|DRUG: methylprednisolone|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Shockless Implant Evaluation
Status: COMPLETED
Conditions: Ventricular Fibrillation|Ventricular Tachycardia
Interventions: DEVICE: Implantable defibrillator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Post-Dialysis Fatigue and Recovery Time in Hemodialysis Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Hemodialysis|Fatigue|Massage
Interventions: OTHER: Hand Massage Group|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Phase 2 Trial of ENV-101 in Patients With Lung Fibrosis (WHISTLE-PF Trial)
Status: NOT_YET_RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis|Progressive Pulmonary Fibrosis|Progressive Fibrosing Interstitial Lung Disease
Interventions: DRUG: ENV-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quadratus Lumborum Block vs Transversus Abdominis Plane Block for Post-cholecystectomy Analgesia
Status: COMPLETED
Conditions: Laparoscopic Cholecystectomy
Interventions: OTHER: Quadratus lumborum block Group (QL)|OTHER: Transversus abdominis plane Group (TAP)|OTHER: Control group (C)|DRUG: Paracetamol infusion|DRUG: Ketorolac analgesia|DRUG: fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Dose-escalation Study of MK-8776 (SCH 900776) With and Without Gemcitabine in Participants With Solid Tumors or Lymphoma (MK-8776-002/P05248)
Status: COMPLETED
Conditions: Hodgkin Disease|Lymphoma, Non-Hodgkin|Neoplasms
Interventions: DRUG: MK-8776|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Addition of Aromatase Inhibitor to Ovarian Stimulation Therapy in IVF Treatment
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Letrozole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Strategies for Protamine Dosing After Anticoagulation in Cardiovascular Surgery
Status: UNKNOWN
Conditions: Anticoagulant Antagonist Toxicity
Interventions: DRUG: Conventional dose|DRUG: Dosing according residual heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Loncastuximab Tesirine With Rituximab Versus Immunochemotherapy in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Status: RECRUITING
Conditions: Relapsed Diffuse Large B-Cell Lymphoma|Refractory Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Loncastuximab Tesirine|DRUG: Rituximab|DRUG: Gemcitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Follow-up Study at Years 2, 3, 4 and 5 Where 2 Dosing Schedules of the Combined Hepatitis A and B Vaccine Were Compared
Status: COMPLETED
Conditions: Hepatitis B|Hepatitis A
Interventions: BIOLOGICAL: Twinrix™ Adult|BIOLOGICAL: Twinrix™ Junior
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Utility of Cable Tie to Decline Reloads in Laparoscopic Anterior Resection of Rectal Cancer
Status: UNKNOWN
Conditions: Modification of Rectal Cancer Surgery
Interventions: DEVICE: Cable Tie
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Obstructive Sleep Apnea in Chronic Kidney Disease
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive|Renal Insufficiency, Chronic
Interventions: DEVICE: CPAP|OTHER: No CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing High Cut-off Haemofiltration With Standard Haemofiltration in Acute Renal Failure
Status: COMPLETED
Conditions: Kidney Failure, Acute|Shock
Interventions: DEVICE: Standard polyamide high flux membrane|DEVICE: High cut-off (super high flux) polyamide membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Potential Effects of Ketoconazole on the Pharmacokinetics of Trabectedin in Patients With Advanced Malignancies
Status: COMPLETED
Conditions: Neoplasm Metastases
Interventions: DRUG: Trabectedin|DRUG: Ketoconazole|DRUG: Dexamethasone or equivalent steroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD7 CAR-T Cell Treatment of Relapsed/Refractory CD7+ T -Acute Lymphoblastic Leukemia/ Lymphoma
Status: UNKNOWN
Conditions: Relapsed/Refractory, High Risk Hematologic Malignancies|T-ALL/Lymphoma
Interventions: BIOLOGICAL: CD7CAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Prehospital eFAST in Accelerating Time to Diagnostics or Definitive Treatment in the Emergency Department
Status: COMPLETED
Conditions: Trauma Splenic|Trauma Abdomen|Liver Injury
Interventions: DIAGNOSTIC_TEST: prehospital extended focused assessment sonography for trauma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Modified Cervical Inversion During CS in Placenta Previa
Status: COMPLETED
Conditions: Placenta Previa
Interventions: PROCEDURE: Cervical inversion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ToleroMune House Dust Mites (HDM) Exposure Chamber Study
Status: COMPLETED
Conditions: Rhinoconjunctivitis
Interventions: BIOLOGICAL: ToleroMune HDM|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Therapy During Surgery in Treating Patients With Non-small Cell Lung Cancer That Can Be Removed by Surgery
Status: COMPLETED
Conditions: Recurrent Non-Small Cell Lung Carcinoma|Stage IIA Non-Small Cell Lung Carcinoma|Stage IIB Non-Small Cell Lung Carcinoma|Stage IIIA Non-Small Cell Lung Cancer|Stage IIIB Non-Small Cell Lung Cancer
Interventions: DRUG: Temoporfin|PROCEDURE: Therapeutic Conventional Surgery|DRUG: Photodynamic Therapy|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of the Levitan Scope for Laryngoscopy and Tracheal Intubation With a Simulated Difficult Airway
Status: COMPLETED
Conditions: Airway Complication of Anaesthesia
Interventions: DEVICE: Laryngoscopy order: 1) MAC, 2) Levitan|DEVICE: Laryngoscopy order: 1) Levitan, 2) MAC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Atezolizumab Trial in Endometrial Cancer - AtTEnd
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Cancer
Interventions: DRUG: Atezolizumab|DRUG: Placebos|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Home Exercise Program for Women With Infants & Young Children
Status: COMPLETED
Conditions: MomZing Exercise Videos Online|Standard Exercise DVD
Interventions: BEHAVIORAL: MomZing Web Program|BEHAVIORAL: Standard Exercise DVD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Two Intensities of Transcranial Direct Current Stimulation to Improve Consciousness in Severely Brain Injured Patients
Status: UNKNOWN
Conditions: Disorder of Consciousness|Minimally Conscious State|Vegetative State|Cognitive Impairment
Interventions: DEVICE: transcranial direct current stimulation (tDCS) / Comparison of current intensities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)
Status: RECRUITING
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Dichloroacetate (DCA)|GENETIC: Genotype
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Alogliptin Plus Metformin Compared to Glipizide Plus Metformin in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Alogliptin|DRUG: Metformin|DRUG: Glipizide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cetuximab, Radiotherapy and Twice Weekly Gemcitabine to Treat Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Cetuximab/Gemcitabine|PROCEDURE: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PMZ-1620 (Sovateltide) in Acute Ischemic Stroke Patients
Status: COMPLETED
Conditions: Acute Stroke|Cerebral Ischemia
Interventions: DRUG: Normal Saline along with standard treatment|DRUG: PMZ-1620 along with standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TIPS Block vs Dual Subsartorial Block
Status: NOT_YET_RECRUITING
Conditions: Anesthesia, Local|Knee Arthropathy
Interventions: PROCEDURE: Triple Injection Perisartorius block|PROCEDURE: Dual sub sartorial block|PROCEDURE: Femoral triangle block|PROCEDURE: Distal adductor canal block|PROCEDURE: Suprasartorial plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nicotinic Acid in Hemodialysis Patients With Hyperphosphatemia
Status: UNKNOWN
Conditions: Hyperphosphatemia
Interventions: DRUG: Nicotinic Acids|DRUG: Calcium Carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Statin Eye Drop in the Management of the Dry Eye
Status: ACTIVE_NOT_RECRUITING
Conditions: Dry Eye Disease
Interventions: DRUG: Statin eye drop|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of 14-day Concomitant Therapy for Helicobacter Pylori Infection
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Amoxicillin,Tetracycline,Furazolidone,Levofloxacin,Vonoprazan fumarate, Esomeprazole ,
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetic Sequencing-Informed Targeted Therapy in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Malignant Pericardial Effusion|Malignant Pleural Effusion|Recurrent Non-small Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: OTHER: cytology specimen collection procedure|PROCEDURE: therapeutic procedure|DRUG: targeted therapy|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Piggyback Sulcoflex Toric IOL for Correcting Refractive Error Following Corneal Transplantation
Status: UNKNOWN
Conditions: Refractive Error|Corneal Implantation|Intraocular Lens Implantation
Interventions: PROCEDURE: toric intraocular lens implantation|PROCEDURE: Sulcoflex intraocular lens implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of First or Second Line Treatment With Tarceva (Erlotinib) in Patients With Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: erlotinib [Tarceva]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the Cryopreserved Formulation of OTL-101 in Subjects With ADA-SCID
Status: COMPLETED
Conditions: Severe Combined Immunodeficiency Due to ADA Deficiency
Interventions: GENETIC: Infusion of autologous cryopreserved EFS-ADA LV CD34+ cells (OTL-101)|DRUG: busulfan|DRUG: PEG-ADA ERT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of an Auto-Regulating Oxygen System Compared to Constant-Flow Oxygen During Walking in Hypoxemic COPD Patients
Status: COMPLETED
Conditions: COPD
Interventions: OTHER: Oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of ABT-493/ABT-530 in Japanese Adults With Genotype 2 Chronic Hepatitis C Virus Infection
Status: COMPLETED
Conditions: Chronic Hepatitis C Virus|Hepatitis C Virus
Interventions: DRUG: ABT-493/ABT-530|DRUG: sofosbuvir (SOF)|DRUG: ribavirin (RBV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Types of Anesthesia on Perioperative Brain Natriuretic Peptide Levels in Parturient Cardiac Patient Undergoing Elective Cesarean Section
Status: COMPLETED
Conditions: General Anesthesia Versus Spinal Anesthesia on BNP Hormone Levels Preoperatively and Postoperatively in Parturient Cardiac Patient Undergoing C.S
Interventions: DIAGNOSTIC_TEST: G.A Group A:
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use of Tirosint®-SOL or Tablet Formulations of Levothyroxine in Pediatric Patients With Congenital Hypothyroidism (CH)
Status: ACTIVE_NOT_RECRUITING
Conditions: Congenital Hypothyroidism
Interventions: DRUG: Tirosint®-SOL|DRUG: Levothyroxine Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of a Hematinic Agent in the Treatment of Postpartum Patients
Status: COMPLETED
Conditions: Postpartum Anemia
Interventions: DRUG: Ferric Carboxymaltose (FCM)|DRUG: Ferrous Sulfate tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Transcatheter Closure of Ostium Secundum ASDs
Status: COMPLETED
Conditions: Atrial Septal Defect
Interventions: DEVICE: GORE® CARDIOFORM ASD Occluder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dopamine and Opioid Receptor Antagonists Reduce Cue-induced Reward Responding and Reward Impulsivity
Status: COMPLETED
Conditions: Addiction
Interventions: DRUG: Placebo|DRUG: Amisulpride|DRUG: Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Cyclophosphamide, Doxorubicin, Vincristine w/ Irinotecan and Temozolomide in Ewings Sarcoma
Status: TERMINATED
Conditions: Bone Cancer|Ewing's Sarcoma
Interventions: DRUG: Irinotecan|DRUG: Vincristine|DRUG: Temozolomide|DRUG: Doxorubicin|DRUG: Cytoxan|DRUG: Pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Optimization During Spinal Anesthesia in the Elderly
Status: NOT_YET_RECRUITING
Conditions: Non Invasive Hemodynamic Monitoring|Proximal Femur Fracture|Fluid Therapy
Interventions: DEVICE: Oscillometric intermittent non-invasive blood pressure|DEVICE: ClearSight
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lidocaine Infusion for Propofol Dose Reduction in ERCP Procedure
Status: UNKNOWN
Conditions: Sedation
Interventions: DRUG: Placebo|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Expanded Access Program (EAP) for Participants With Advanced Cancers and Fibroblast Growth Factor Receptor (FGFR) Genetic Alterations Who Have Exhausted All Treatment Options
Status: APPROVED_FOR_MARKETING
Conditions: Advanced Cancers and FGFR Genetic Alterations
Interventions: DRUG: Erdafitinib
Study Type: EXPANDED_ACCESS
Clinical trial: Computed Tomography Urography (CTU) vs Intravenous Urography (IVU) on Patients at Risk of Urothelial Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Bladder Cancer
Interventions: DEVICE: Computed Tomography Urography (CTU)|OTHER: Intravenous Urography (IVU)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Observational Study of Glycaemic Control in Patients Uncontrolled on Oral Antidiabetic Agents and Starting With 1 (Once) Daily Levemir® (Insulin Detemir) as the Treatment of Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin detemir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Repeated-dose Safety, Efficacy, Pharmacokinetic and Pharmacodynamic of CTAP101, Immediate-release Calcifediol, High-dose Cholecalciferol, and Paricalcitol Plus Low-dose Cholecalciferol in Patients With Secondary Hyperparathyroidism, Chronic Kidney Disease 3-4 and Vitamin D Insufficiency
Status: COMPLETED
Conditions: Secondary Hyperparathyroidism Due to Renal Causes|Vitamin D Insufficiency|CKD Stage 3|CKD Stage 4
Interventions: DRUG: Calcifediol Oral Capsule|DRUG: Calcifediol Oral Product|DRUG: Cholecalciferol|DRUG: Paricalcitol Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aspen™ Ultrasound System and Aspen Rehabilitation Technique in the Treatment of Capsular Contracture
Status: TERMINATED
Conditions: Capsular Contracture of Breast, Grade III
Interventions: DEVICE: Aspen(TM) Ultrasound System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of β-Carotene, Vitamin D3 and Zinc on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates
Status: UNKNOWN
Conditions: Hyaline Membrane Disease|Necrotizing Enterocolitis of Newborn
Interventions: DIETARY_SUPPLEMENT: Beta carotene|DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Zinc|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Problem Solving Intervention for Post-ICU Cognitive Impairment in Older Adults
Status: COMPLETED
Conditions: Critical Illness|Mechanical Ventilation Complication|Delirium|Cognitive Impairment
Interventions: BEHAVIORAL: Post-ICU Problem Solving
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hemodialysis and Erythrocyte Fatty-Acid Status: a Lipidomics Study
Status: COMPLETED
Conditions: Fatty Acid Metabolism|Erythrocytes|Lipidomics|Hemodialysis
Interventions: OTHER: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neuroimaging Predictors of Improvement to Pivotal Response Treatment (PRT) in Young Children With Autism
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Autism
Interventions: BEHAVIORAL: Pivotal Response Treatment Program (PRT-P)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2a Study to Investigate the Effects of Repeated Administration of AeroDerm in Subjects With Atopic Eczema
Status: COMPLETED
Conditions: Atopic Eczema
Interventions: DRUG: Aeroderm (also known as pitrakinra, AER 001, BAY 16-9996)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: caBozantinib in cOllectiNg ductS Renal Cell cArcInoma
Status: COMPLETED
Conditions: Collecting Duct Carcinoma (Kidney)
Interventions: DRUG: cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fish Oil Versus Statins Versus Placebos in Reducing Atrial Fibrillation in Patients Undergoing Thoracic Surgery for Lung Cancer
Status: TERMINATED
Conditions: Advanced Cancers
Interventions: DRUG: Atorvastatin|DIETARY_SUPPLEMENT: Fish Oil Supplement|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Study for the Evaluation of Tolerability of Five Dose Levels of Cand5
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DRUG: bevasiranib|DRUG: bevasiranib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 20-Week Multicentre, Open Study Assessing the Efficacy and Safety of Apremilast in Patients > 6 Years of Age With EB Simplex Generalized
Status: NOT_YET_RECRUITING
Conditions: Inflammatory Epidermal Genodermatoses
Interventions: DRUG: Apremilast treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Overall Pain Relief and Safety of Intravenous (IV) CR845 in Patients Undergoing Abdominal Surgery
Status: COMPLETED
Conditions: Post Abdominal Surgery Pain
Interventions: DRUG: CR845 IV 1 mcg/kg|DRUG: CR845 IV 0.5 mcg/kg|DRUG: Placebo IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Healthy Pediatric Participants With Influenza-Like Symptoms
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: Baloxavir Marboxil|DRUG: Oseltamivir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Effect of Paroxetine Mediated CYP2D6 Inhibition on the Pharmacokinetics of Tamsulosin in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tamsulosin|DRUG: Paroxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Behavioral Therapies for Treating Adolescents With Post-Traumatic Stress Disorder Related to Sexual Abuse
Status: COMPLETED
Conditions: PTSD
Interventions: BEHAVIORAL: Prolonged Exposure for Adolescents|BEHAVIORAL: Client Centered Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Satavaptan Dose-Ranging Study in the Prevention of Ascites
Status: COMPLETED
Conditions: Ascites|Liver Cirrhosis
Interventions: DRUG: satavaptan (SR121463B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy and Safety of Subcutaneous Methylnaltrexone (MOA-728) for the Treatment of Opioid-Induced-Constipation
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: Methylnaltrexone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Safety, and Tolerability of Intravenous Posaconazole Solution Followed by Oral Posaconazole Suspension in Subjects at High Risk for Invasive Fungal Infections (P05520)
Status: COMPLETED
Conditions: Fungal Infection
Interventions: DRUG: Posaconazole|DRUG: Dextrose 5% in water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Acupuncture for Blood Pressure Fluctuation During Total Laparoscopic Hysterectomy
Status: RECRUITING
Conditions: Total Laparoscopic Hysterectomy
Interventions: DEVICE: acupuncture|DEVICE: placebo acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Desflurane and Sevoflurane Minimal Flow Anesthesia on Recovery and Anesthetic Depth
Status: UNKNOWN
Conditions: Anesthesia
Interventions: PROCEDURE: Minimal flow anesthesia (fresh gas flow <0.5 l/min) using Sevoflurane|PROCEDURE: Minimal flow anesthesia (fresh gas flow <0.5 l/min) using Desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE