pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Ticagrelor and Endothelial Function
Status: UNKNOWN
Conditions: Antiplatelet Agents; Endothelial Function; Pleotropic Effects
Interventions: DRUG: ticagrelor|DRUG: prasugrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Crux Biomedical Evaluation of the Crux Inferior Vena Cava Filter System 3 ("RETRIEVE 3")
Status: COMPLETED
Conditions: Pulmonary Embolism
Interventions: DEVICE: Inferior Vena Cava Filter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Occipital Transcranial Direct Current Stimulation in Fibromyalgia
Status: UNKNOWN
Conditions: Fibromyalgia
Interventions: DEVICE: Transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Rituximab-Gemcitabine-Dexamethasone-Platinum (R-GDP) With or Without Selinexor in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma
Status: RECRUITING
Conditions: Relapsed/Refractory Diffuse Large B-cell Lymphoma
Interventions: DRUG: Selinexor (combination therapy)|DRUG: Selinexor (combination therapy)|DRUG: Selinexor (combination therapy)|DRUG: Placebo matching for Selinexor (combination therapy)|DRUG: Rituximab (combination therapy)|DRUG: Rituximab (combination therapy)|DRUG: Gemcitabine (combination therapy)|DRUG: Dexamethasone (combination therapy)|DRUG: Cisplatin (combination therapy)|DRUG: Selinexor (continuous therapy)|DRUG: Placebo matching for Selinexor (continuous therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Opioids Titration in Hospice Patients
Status: WITHDRAWN
Conditions: Pain|Solid Tumor
Interventions: BEHAVIORAL: telephone-based intervention|OTHER: communication intervention|OTHER: intervention by caregiver|OTHER: medical chart review|OTHER: survey administration|PROCEDURE: end-of-life treatment/management|PROCEDURE: pain therapy|PROCEDURE: psychosocial assessment and care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Advance Care Planning: Communicating With Outpatients for Vital Informed Decision
Status: COMPLETED
Conditions: Advanced Care Planning|Shared Decision Making|Video Decision Aids|Communication Skills|Advance Directives|Natural Language Processing|Covid19
Interventions: OTHER: VitalTalk communication skills training|OTHER: ACP Decisions Video Program|OTHER: Intervention training:|OTHER: Medical Record Review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Tarceva (Erlotinib) and Avastin (Bevacizumab) in Patients With Advanced or Metastatic Liver Cancer.
Status: COMPLETED
Conditions: Liver Cancer
Interventions: DRUG: bevacizumab (Avastin)|DRUG: erlotinib (Tarceva)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Relatlimab Plus Nivolumab Versus Nivolumab Alone in Participants With Advanced Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: BIOLOGICAL: Relatlimab|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuroinflammatory Response in Patients With ICH and IVH Treated With rtPA
Status: COMPLETED
Conditions: Hypertensive Intracerebral Hemorrhage|Intraventricular Hemorrhage|Brain Injuries
Interventions: DRUG: intraventricual recombinant tissue plasminogen activator application
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Outcome of Two Protocols Used to Prepare Endometrium for Frozen Embryo Transfer
Status: COMPLETED
Conditions: Infertility|Infertility, Female|Infertility, Male
Interventions: DRUG: Estradiol Valerate|DRUG: Progesterone|DRUG: Aromatase inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Investigation of Recombinant Human Thrombopoietin (rhTPO) Combining Cyclosporin A Versus Cyclosporin A in Management of Steroid-Resistant/Relapsed Immune Thrombocytopenia （ITP）
Status: WITHDRAWN
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Cyclosporin A|DRUG: rhTPO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing the Bioavailability of TAS-102 Tablets to an Oral Solution Containing Equivalent Amounts of FTD and TPI
Status: COMPLETED
Conditions: Advanced Solid Tumors (Excluding Breast Cancer)
Interventions: DRUG: TAS-102 tablets|DRUG: TAS-102 oral solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Skin Pigmentation and Race/Ethnicity Factors on the Accuracy of Masimo Pulse Oximeters
Status: TERMINATED
Conditions: Healthy
Interventions: DEVICE: INVSENSOR00050|DEVICE: RD SET SpO2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Relation Between Intrabdominal Pressure and Collapsibility Index of Inferior Vena Cava Before and After Fluid Therapy
Status: COMPLETED
Conditions: Abdominal Compartment Syndrome
Interventions: OTHER: Fluid therapy (Saline Normal)|OTHER: Fluid therapy (Saline Normal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Genome-based Management of Patients in Precision Medicine (Ge-Med) Towards a Genomic Health Program
Status: RECRUITING
Conditions: Rare Diseases|Genetic Predisposition to Disease
Interventions: GENETIC: WGS Diagnostic: Blood take for genetic diagnostic
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Does Posterior Reconstruction of the Rhabdosphincter Improve Early Recovery of Continence After Robotic-Assisted Radical Prostatectomy?
Status: UNKNOWN
Conditions: Urinary Incontinence
Interventions: PROCEDURE: Posterior reconstruction of the rhabdosphincter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicentre, Double-blind Study Versus Placebo on Impact and Safety of Extramel® 140 IU on Perceived Stress, Physical and Intellectual Fatigue, Pain Perception if Present, and the Impact on the Quality of Life
Status: COMPLETED
Conditions: Life Stress|Fatigue|Pain|Quality of Life
Interventions: DIETARY_SUPPLEMENT: Extramel 10 mg - 140 UI SOD|DIETARY_SUPPLEMENT: Placebo - Excipient only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension
Status: COMPLETED
Conditions: Pulmonary Hypertension|Congenital Heart Disease|Pediatric Congenital Heart Disease
Interventions: PROCEDURE: cardiac catheterization|RADIATION: Cardiac MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Examine the Pharmacokinetics, Tolerability, Safety and Efficacy of Exenatide Once Weekly Suspension
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: exenatide once weekly|DRUG: exenatide once weekly|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Second-Line Chemotherapy With Ramucirumab +/- Paclitaxel in Elderly Advanced Gastric or Gastroesophageal Junction Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Stomach Cancer|Stomach Neoplasm|Gastric Cancer|Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Ramucirumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VATS Lobectomy for Clinical Stage IB or II Lung Cancer
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung|Thoracic Surgery, Video-Assisted
Interventions: PROCEDURE: thoracoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyclophosphamide, Doxorubicin, Vincristine, Prednisone, Rituximab Pateinets With Aggresive NHL
Status: COMPLETED
Conditions: Lymphoma|Non Hodgkin's Lymphoma
Interventions: DRUG: Cyclophosphamide, Doxorubicin, Vincristine and Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Obinutuzumab, Venetoclax, and Lenalidomide in Treating Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: B-Cell Lymphoma, Unspecified|Grade 1 Follicular Lymphoma|Grade 2 Follicular Lymphoma|Grade 3a Follicular Lymphoma|Recurrent Burkitt Lymphoma|Recurrent Diffuse Large B-Cell Lymphoma|Recurrent Follicular Lymphoma|Recurrent Marginal Zone Lymphoma|Refractory Burkitt Lymphoma|Refractory Diffuse Large B-Cell Lymphoma|Refractory Follicular Lymphoma|Transformed Recurrent Non-Hodgkin Lymphoma|B-Cell
Interventions: DRUG: Lenalidomide|BIOLOGICAL: Obinutuzumab|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A New Technique for Determining Limb Occlusion Pressure
Status: COMPLETED
Conditions: Tourniquet Safety and Effectiveness
Interventions: DEVICE: Personalized Tourniquet Instrument|DEVICE: Handheld Doppler ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy And Safety Of An Innovative Treatment Of Opiate Use Disorders
Status: COMPLETED
Conditions: Opioid-use Disorder|Opioid Dependence|Opioid Abuse
Interventions: DEVICE: supra-luminous LED|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Anatomo-functional Correlation of the Upper Airways
Status: ACTIVE_NOT_RECRUITING
Conditions: Sleep Apnea Syndromes
Interventions: OTHER: Measurement of pharyngeal critical airway closing pressure|OTHER: Acoustic pharyngometry|OTHER: Upper airway ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Comparative Efficacy and Safety of Fenoverine
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Fenoverine|DRUG: Timebutine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Compare the Pharmacokinetics Profiles of ISO 20, IBU 200 and IBU Plus ISO Combinations 200 + 20
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy (DMD)
Interventions: DRUG: Isosorbide Dinitrate|DRUG: Ibuprofen|OTHER: Ibuprofen and Isosorbide Dinitrate combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Percutaneous Coronary Intervention in Left Main Coronary Artery Disease in Patients With Acute Coronary Syndrome at Sohag University Hospitals
Status: RECRUITING
Conditions: Left Main Coronary Artery Disease With Acute Coronary Syndrome
Interventions: PROCEDURE: Percutaneous Coronary Intervention in Left Main Artery Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Testing the Safety of M6620 (VX-970) When Given With Standard Whole Brain Radiation Therapy for the Treatment of Brain Metastases From Non-small Cell Lung Cancer, Small Cell Lung Cancer, or Neuroendocrine Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Lung Neuroendocrine Neoplasm|Metastatic Lung Non-Small Cell Carcinoma|Metastatic Lung Small Cell Carcinoma|Metastatic Malignant Neoplasm in the Brain|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: DRUG: Berzosertib|OTHER: Quality-of-Life Assessment|PROCEDURE: Therapeutic Conventional Surgery|RADIATION: Whole-Brain Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification and Treatment of Cervical Abnormalities in Perú Through Integration of Pocket Colposcopy and Telemedicine
Status: COMPLETED
Conditions: Cervical Cancer|HPV Infection|HIV Infections
Interventions: DEVICE: Colposcopy using pocket colpscope and thermocoagulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modulation Therapy for Locally Advanced NPC Based on Plasma EBV DNA Level Post-ICT
Status: RECRUITING
Conditions: Nasopharyngeal Cancer
Interventions: DRUG: Toripalimab|OTHER: Induction chemotherapy and concurrent chemoradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate a Fixed Combination of Acetaminophen/Naproxen Sodium in Acute Postoperative Pain Following Bunionectomy
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Acetaminophen/Naproxen Sodium Fixed Combination|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CT-Based Changes in Bone and Marrow Among Patients on Oral Steroids
Status: RECRUITING
Conditions: Asthma|Bone Density, Low|Oral Steroid-Dependent Asthma (Disorder)
Interventions: RADIATION: CT Scan|RADIATION: DXA Scan|OTHER: Steroid Intake Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Different Dietary Therapies on Intestinal Barrier Integrity in Patients With Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome-IBS
Interventions: DIETARY_SUPPLEMENT: Group 1 received a regular constipation diet|DIETARY_SUPPLEMENT: Group 2 received a constipation diet rich in soluble fiber|DIETARY_SUPPLEMENT: Group 3 received a constipation diet supplemented with probiotic yogurt.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Telmisartan 40 mg Plus Hydrochlorothiazide (HCTZ) 12.5 mg vs. Telmisartan 40 mg Alone in Patients With Essential Hypertension Who Fail to Respond Adequately to Telmisartan Monotherapy
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan 40 mg/HCTZ 12.5 mg|DRUG: Telmisartan 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of Using EndoClear-Endoscopic Lens Cleaning Device
Status: COMPLETED
Conditions: Laparoscopic Abdominal Surgery
Interventions: DEVICE: EndoClear Lens Cleaning Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Fish Oil in Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DIETARY_SUPPLEMENT: Omega-3 fatty acids|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Physical Training in Patients With POTS After Covid-19
Status: ACTIVE_NOT_RECRUITING
Conditions: Covid19|Post-acute Covid-19 Syndrome|Postural Orthostatic Tachycardia Syndrome
Interventions: OTHER: Physical exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of EXC 001 in Subjects Who Have Participated in Prior Studies of EXC 001
Status: COMPLETED
Conditions: Reduction in Severity of Skin Scarring
Interventions: DRUG: EXC 001 (currently called PF-06473871)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Erlotinib in Inoperable and Metastatic Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Bevacizumab|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancement of Cerebral Vasoreactivity and Cognition by Intranasal Insulin in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Intranasal insulin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Clinical Trial in Males With BPH (Enlarged Prostate)
Status: COMPLETED
Conditions: Urinary Retention|Prostatic Hyperplasia|Benign Prostatic Hypertrophy
Interventions: DRUG: Alfuzosin (SL770499)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Breaking up Prolonged Sedentary Behavior to Improve Cardiometabolic Health
Status: RECRUITING
Conditions: Sedentary Behavior|Cardiometabolic Risk Factors|Blood Pressure|Glucose
Interventions: BEHAVIORAL: Sedentary Break (Walking) Condition|BEHAVIORAL: Sitting (Control) Condition|BEHAVIORAL: Controlled Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVD
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus|Cardiovascular Disease|Premature Atherosclerosis
Interventions: DRUG: anifrolumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Exercise in the Treatment of Upper Cross Syndrome
Status: NOT_YET_RECRUITING
Conditions: Upper Cross Syndrome
Interventions: OTHER: Physical therapy program with upper cross syndrome specific exercises|OTHER: Physical therapy program with conventional neck strengthening exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Supportive Care Intervention (ROAR-LCT) for Patients With Stage IIIA, IIIB, and IV Lung Cancer, ROAR-LCT Trial
Status: RECRUITING
Conditions: Advanced Lung Non-Small Cell Carcinoma|Advanced Lung Small Cell Carcinoma|Extensive Stage Lung Small Cell Carcinoma|Stage IIIA Lung Cancer AJCC v8|Stage IIIB Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8|Unresectable Lung Non-Small Cell Carcinoma|Unresectable Lung Small Cell Carcinoma
Interventions: OTHER: Best Practice|OTHER: Exercise Intervention|PROCEDURE: Physical Therapy|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Relaxation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: mTOR as Mediator of Insulin Sensitivity Study
Status: RECRUITING
Conditions: Insulin Sensitivity
Interventions: OTHER: Exercise|PROCEDURE: Insulin infusion|DRUG: Placebo|DRUG: Rapamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Thrombolysis With rhPro-UK in 4.5-6 Hours After Acute Ischemic Stroke in a Double-blinded,Controlled Trial
Status: COMPLETED
Conditions: Acute Ischaemic Stroke
Interventions: DRUG: Recombinant human urokinase|DRUG: Aspirin|DRUG: rhPro-UK simulation agent|DRUG: Aspirin simulation agent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation and Expansion Clinical Trial of Irinotecan Liposome Combined With Oxaliplatin and 5-FU/LV Plus Bevacizumab as First-line Treatment of Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Irinotecan Liposome|DRUG: Oxaliplatin|DRUG: 5-FU|DRUG: LV|DRUG: Bevacizumab|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Transmission Season on Outcome of Treatment of Schistosoma Haematobium Infection in Mozambique
Status: COMPLETED
Conditions: Hematuria|Hydronephrosis
Interventions: DRUG: praziquantel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anlotinib Combined With Chemotherapy and Neoadjuvant Therapy for Hormone Receptor-positive HER-2 Negative Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer Stage II
Interventions: DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Oral Formulations of Anastrozole in Healthy Chinese Volunteers Under Fed Condition
Status: UNKNOWN
Conditions: Healthy Volunteers
Interventions: DRUG: test-anastrozole tablet (Salutas Pharma GmbH)|DRUG: reference-anastrozole tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effectiveness of the Ultrasound Guided Injections in Patients With Shoulder Impingement Syndrome
Status: COMPLETED
Conditions: Shoulder Impingement|Ultrasound Guided Injection
Interventions: DRUG: bupivacaine and methylprednisolone|DRUG: bupivacaine and methylprednisolone|DRUG: bupivacaine and methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008)
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: Pembrolizumab|BIOLOGICAL: Pembrolizumab/Quavonlimab|BIOLOGICAL: Pembrolizumab/Favezelimab|BIOLOGICAL: Pembrolizumab/Vibostolimab|BIOLOGICAL: MK-4830
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interrupted Subdermal Suture Spacing During Linear Wound Closures and the Effect on Wound Cosmesis
Status: COMPLETED
Conditions: Interrupted Subdermal Suture
Interventions: DEVICE: Vicryl absorbable suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of Finastride Effect in Different Dosage on the Amount of Perioperative Bleeding in Transurthral Resection of Prostate
Status: COMPLETED
Conditions: Benign Prostate Hyperplasia
Interventions: PROCEDURE: TURP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Different Doses of Dexmedetomidine on Fentanyl-induced Cough
Status: UNKNOWN
Conditions: Fentanyl-induced Cough
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability and Drug-drug Interaction Study With MT-7117 and a Proton Pump Inhibitor
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: MT-7117|DRUG: PPI|DIETARY_SUPPLEMENT: Acidic beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Continuous Vs Intermittent Non Invasive Blood Pressure Monitoring in Preventing Post Operative Organ Failure
Status: RECRUITING
Conditions: Blood Pressure Determination|Hemodynamic Monitoring|Postoperative Complications
Interventions: DEVICE: Continuous Non Invasive Blood Pressure Monitoring|DEVICE: Intermittent Non Invasive Blood Pressure Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Open-label, Pharmacokinetic, Safety and Efficacy Study of Adjunctive Brivaracetam in Children With Epilepsy.
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Brivaracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is the Rate of Early Mobilisation in Hip Fracture Patients Using Alfentanil Better Than Standard Opioid Analgesia?
Status: RECRUITING
Conditions: Hip Injuries|Hip Fractures|Pain|Post Operative Pain|Early Ambulation
Interventions: DRUG: Alfentanil|DRUG: Oxycodone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Study of Minocycline for Negative and Cognitive Symptoms in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: minocycline|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Control With Pre-operative Cryoneurolysis Following TKA
Status: WITHDRAWN
Conditions: Osteo Arthritis Knee
Interventions: PROCEDURE: Cryoneurolysis (Iovera)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of SLAMF7 FPBMC/CS-1 FPBMC in Relapsed/Refractory Multiple Myeloma
Status: WITHDRAWN
Conditions: Multiple Myeloma
Interventions: DRUG: SLAMF7 FPBMC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Project of Familial Hypercholesterolemia Screening in Newborns in the Czech Republic
Status: UNKNOWN
Conditions: Familial Hypercholesterolaemia
Interventions: DIAGNOSTIC_TEST: Total cholesterol (TC) level test and direct Low density lipoprotein cholesterol (LDL-C) level test|DIAGNOSTIC_TEST: DNA testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study on the Safety of BAY 63-2521, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given as a Single Oral Dose of 1 mg Tablet in Participants With Impaired Liver Function and Healthy Participants Matched for Age-, Gender-, and Weight
Status: COMPLETED
Conditions: Clinical Pharmacology
Interventions: DRUG: Riociguat (Adempas, BAY 63-2521)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Impact of Velcade(TM)on Antibody Secreting Cells in Sensitized Renal Allograft Candidates
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance and Safety of the Gedea Pessary in Adult Women With Bacterial Vaginosis
Status: COMPLETED
Conditions: Bacterial Vaginosis
Interventions: DEVICE: Gedea Pessary pHyph|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Conatumumab, Gemcitabine Hydrochloride, Capecitabine, and Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer
Status: WITHDRAWN
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: conatumumab|DRUG: capecitabine|DRUG: gemcitabine hydrochloride|RADIATION: 3-dimensional conformal radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quality of Recovery After General or Spinal Anesthesia for Inguinal Hernia Repair
Status: COMPLETED
Conditions: Quality of Life|Pain, Postoperative|Personal Satisfaction|Postoperative Complication
Interventions: PROCEDURE: Local Group|PROCEDURE: Spinal anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Parameters of Osteosarcopenia in Patients With Hip Fracture
Status: RECRUITING
Conditions: Osteoporotic Fracture of Femur|Osteoarthritis, Hip
Interventions: DIAGNOSTIC_TEST: SARC-F questionnaire|DIAGNOSTIC_TEST: Bone tissue histology|DIAGNOSTIC_TEST: Muscle tissue histology|DIAGNOSTIC_TEST: Myostatin serum levels|DIAGNOSTIC_TEST: Insulin-like growth factor 1 (IGF-1) serum levels|OTHER: Frequency food questionnaire|OTHER: Gut microbiota profiling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The HPV 9-10 Trial: Early Initiation of HPV Vaccination
Status: RECRUITING
Conditions: HPV
Interventions: BEHAVIORAL: (Intervention) Recommending HPV vaccine for patients 9-10 years of age|BEHAVIORAL: (Control) Recommending HPV vaccine for patients 11-12 years of age
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: HIV Prevention With Adolescents: Neurocognitive Deficits and Treatment Response
Status: WITHDRAWN
Conditions: Risk Reduction Behavior|Sexual Behavior|Health Behavior|Drinking Behavior|Adolescent Behavior
Interventions: BEHAVIORAL: SEXUAL RISK REDUCTION + ALCOHOL RISK REDUCTION|BEHAVIORAL: INFORMATION-ONLY SEXUAL RISK REDUCTION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mobile Phone-Based Smoking-Cessation Intervention for Smoking Parents
Status: NOT_YET_RECRUITING
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: 5A's/5R's advice|OTHER: Health warning leaflet|BEHAVIORAL: AI-powered chatbot support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transdermal Lisuride: a Trial for the Treatment of Patients With Restless Legs Syndrome (RLS)
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DRUG: Lisuride|DRUG: Ropinirole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Building Equitable Linkages With Interprofessional Education Valuing Everyone
Status: ENROLLING_BY_INVITATION
Conditions: Pregnancy Related|Postpartum|Pain
Interventions: BEHAVIORAL: BELIEVE IPE Training|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomized Study to Evaluate the Effect of Obicetrapib on Top of Maximum Tolerated Lipid-Modifying Therapies
Status: ACTIVE_NOT_RECRUITING
Conditions: Dyslipidemias|High Cholesterol|Hypercholesterolemia|Familial Hypercholesterolemia|Atherosclerotic Cardiovascular Disease
Interventions: DRUG: Placebo|DRUG: Obicetrapib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Inulin Supplementation on Colorectal Surgery Outcomes
Status: NOT_YET_RECRUITING
Conditions: Anastomotic Complication
Interventions: DIETARY_SUPPLEMENT: Inulin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Feasibility of the XFLO Expander System (Mercury)
Status: ACTIVE_NOT_RECRUITING
Conditions: Benign Prostatic Hyperplasia
Interventions: DEVICE: XFLO Expander System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myocet® in Children With Relapsed or Refractory Non-brainstem Malignant Glioma
Status: COMPLETED
Conditions: Malignant Glioma
Interventions: DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus Erithematosus Study Protocol
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus (SLE)
Interventions: BIOLOGICAL: Blood sample|BIOLOGICAL: Urine sample|BIOLOGICAL: Saliva sample|BIOLOGICAL: Stood sample|PROCEDURE: Tissue sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PD-1, LAG-3 and TIM-3 Checkpoint Blockade in DLBCL
Status: WITHDRAWN
Conditions: Diffuse Large B Cell Lymphoma|Lymphoma, B-Cell|Lymphoma, Follicular
Interventions: DRUG: Retifanlimab, INCAGN02385, INCAGN02390
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing HIV Risk in Urban Women: Soap Opera Videos on Video-Capable Cell Phones
Status: COMPLETED
Conditions: HIV/AIDS|Sexual Behavior|Woman's Role|Risk Behavior
Interventions: OTHER: Love, Sex, & Choices video series|OTHER: Messages in text
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Anti-Tac(Fv)-PE38 (LMB-2) to Treat Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia|Lymphocytic|Chronic
Interventions: DRUG: LMB-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Psycho-oncological Intervention on Well-being of Patients With Advanced Prostate Cancer on LHRH Analogs and Their Partners. A Randomized Controlled Pilot Study.
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: OTHER: Psychological counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of MGL-3196 in Patients With Heterozygous Familial Hypercholesterolemia (HeFH)
Status: COMPLETED
Conditions: Heterozygous Familial Hypercholesterolemia
Interventions: DRUG: MGL-3196|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HOBOE: A Phase 3 Study of Adjuvant Triptorelin and Tamoxifen, Letrozole, or Letrozole and Zoledronic Acid in Premenopausal Patients With Breast Cancer.
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: tamoxifen|DRUG: triptorelin|DRUG: letrozole|DRUG: zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Intravenous K201 on the Restoration of Sinus Rhythm in Subjects With Symptomatic Atrial Fibrillation
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: DRUG: saline|DRUG: K201
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Circulating Cell-free DNA in Metastatic Melanoma Patient: Mutational Analyses in Consecutive Measurement Before and After Chemotherapy
Status: COMPLETED
Conditions: Metastatic (Stage IV) Melanoma
Interventions: PROCEDURE: blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Testing the Addition of M6620 (VX-970, Berzosertib) to Usual Chemotherapy and Radiation for Head and Neck Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Carcinoma of Unknown Primary|Head and Neck Squamous Cell Carcinoma|Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7|Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7|Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7|Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7|Stage III Sinonasal Squamous Cell Carcinoma AJCC v6 and v7|Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7|Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7|Stage IV Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7|Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7|Stage IV Sinonasal Squamous Cell Carcinoma AJCC v7
Interventions: DRUG: Berzosertib|DRUG: Cisplatin|PROCEDURE: Computed Tomography|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Odevixibat in Children With Biliary Atresia Who Have Undergone a Kasai HPE (BOLD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Biliary Atresia
Interventions: DRUG: Odevixibat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Safety and Efficacy of IDP-123 Lotion to Tazorac Cream in the Treatment of Acne Vulgaris
Status: UNKNOWN
Conditions: Acne Vulgaris
Interventions: DRUG: IDP-123 Lotion|DRUG: Tazorac Cream, 0.1%,|DRUG: Vehicle Cream|DRUG: Vehicle Lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, Radiation Dosimetry, and PET Imaging Properties of 89Zr-labeled hNd2 (NMK89) in Patients With Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: NMK89
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Changes in the Upper Airway Volume After Rapid Maxillary Expansion in Adults Using Pure Skeletal Anchorage
Status: COMPLETED
Conditions: Orthodontic Appliance Complication|Dental Malocclusion|Bone Anchored Rapid Maxillary Expansion|Maxillary Hypoplasia|BAME
Interventions: PROCEDURE: Rapid Maxillary Expansion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prospective Cohort of Patients With Newly Diagnosed Glioblastoma: Analysis of MMP2 and MMP9 Expression and Correlation to Neuro-imaging Features.
Status: RECRUITING
Conditions: Brain Tumor
Interventions: BIOLOGICAL: Blood sample|BIOLOGICAL: Tumor sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety Study of PDT Using Photofrin in Unresectable Advanced Perihilar Cholangiocarcinoma (OPUS)
Status: TERMINATED
Conditions: Hilar Cholangiocarcinoma
Interventions: DRUG: Photodynamic therapy-Photofrin|PROCEDURE: Stenting procedure|DRUG: Chemotherapy regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LVAD Versus GDMT in Ambulatory Advanced Heart Failure Patients
Status: RECRUITING
Conditions: End-stage Heart Failure
Interventions: DEVICE: HeartMate 3 TM Left Ventricular Assist System|OTHER: Guideline Directed Medical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Inhibition With Neuromuscular Electrical Stimulation
Status: COMPLETED
Conditions: Healthy Participants
Interventions: OTHER: Volitional Contractions (VOL)|DEVICE: Neuromuscular Electrical Stimulation (NMES)|DEVICE: Noxious Electrical Stimulation (NXES)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bevacizumab Plus Gemcitabine, Docetaxel, Melphalan, and Carboplatin in Ovarian Cancer Patients
Status: TERMINATED
Conditions: Ovarian Cancer
Interventions: DRUG: Bevacizumab|DRUG: Carboplatin|DRUG: Docetaxel|DRUG: Gemcitabine|DRUG: Melphalan|PROCEDURE: Stem Cell Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Oxygen Treatment (HBOT) During Methadone Tapering
Status: RECRUITING
Conditions: Opioid Use Disorder
Interventions: COMBINATION_PRODUCT: Hyperbaric Oxygen Treatment Full|COMBINATION_PRODUCT: Hyperbaric Oxygen Treatment Partial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Battlefield Acupuncture for Pain in Hidradenitis Suppurativa
Status: RECRUITING
Conditions: Hidradenitis Suppurativa
Interventions: PROCEDURE: Battlefield Acupuncture|PROCEDURE: Sham Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Valproic Acid and Platinum-based Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Head and Neck Cancer|Oral Cavity Cancer|Oropharyngeal Cancer
Interventions: DRUG: Valproic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of NPC-07 for Fluorescence-guided Resection of Malignant Gliomas
Status: COMPLETED
Conditions: Malignant Glioma
Interventions: DRUG: NPC-07 for oral administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Epidural Versus Paravertebral Block Analgesia After Hepatectomy
Status: RECRUITING
Conditions: Pain Control After Elective Hepatectomy
Interventions: PROCEDURE: Bupivacaine and Hydromorphone|PROCEDURE: Ropivacaine and Hydromorphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Health-Enhancing Adapted Physical Activity Program at "Mon Stade"
Status: RECRUITING
Conditions: Exercise Therapy|Behavior and Behavior Mechanisms|Adherence, Patient|Lifestyle, Sedentary|Life Style|Life Style, Healthy|Cost-Benefit Analysis|Prescriptions|Physical Activity|Adapted Physical Activity
Interventions: BEHAVIORAL: Adapted Physical Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial Comparing the Effect of a Paravertebral Block on Pain Post Percutaneous Nephrolithotomy
Status: TERMINATED
Conditions: Nephrolithiasis
Interventions: OTHER: Paravertebral Block (PVB)|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction Study With BI 201335 and Methadone or Buprenorphine/Naloxone
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: BI 201335|DRUG: BI 201335
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: B Cell Maturation Antigen Targeted CAR-T Cells in Treatment With Relapsed and Refractory Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma|Relapse Multiple Myeloma|Refractory Multiple Myeloma
Interventions: BIOLOGICAL: BCMA CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Finding Trial of F-627 in Women With Breast Cancer Receiving Myelotoxic Chemotherapy
Status: COMPLETED
Conditions: Breast Cancer|Neutropenia
Interventions: DRUG: F-627|DRUG: Neulasta® (pegfilgrastim)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Routine Early vs Delayed Amniotomy for Preterm Pregnancies: A Randomized Open Label Trial
Status: TERMINATED
Conditions: Labor, Premature
Interventions: PROCEDURE: Early Artificial rupture of membranes|PROCEDURE: Delayed Artificial rupture of membranes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polymorphism C677T MTHFR and Effects of Folate Intake
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: OTHER: 191 mcg/day of Folate|OTHER: 90 mcg / day of Folate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: PF-07284892 in Participants With Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: PF-07284892|DRUG: lorlatinib|DRUG: binimetinib|BIOLOGICAL: cetuximab|DRUG: encorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT