pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study Using Botulinum Toxin Type A in Adolescents With Axillary Hyperhidrosis
Status: COMPLETED
Conditions: Hyperhidrosis
Interventions: BIOLOGICAL: Botulinum Toxin Type A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AutoInflammatory Disease Alliance Registry (AIDA)
Status: RECRUITING
Conditions: Hereditary Autoinflammatory Diseases|Schnitzler Syndrome|Behcet Syndrome|PFAPA Syndrome|Still Disease|Autoinflammatory Syndrome, Unspecified|Uveitis|Scleritis|Vexas Syndrome
Interventions: OTHER: No intervention is foreseen by the protocol.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Associations Between the Gastric Mucosal Pathology and the Eradication Rate of H.Pylori :A Multicenter Study
Status: UNKNOWN
Conditions: Helicobacter Pylori
Interventions: DRUG: bismuth-containing quadral therapy based on antibiotic susceptibility
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Aprepitant Versus Ondansetron in Preoperative Triple-therapy Treatment of Nausea and Vomiting
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting (PONV)|Nausea
Interventions: DRUG: Aprepitant|DRUG: Ondansetron|DRUG: Promethazine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pragmatic Trial of Messaging to Providers About Treatment of Hyperlipidemia (PROMPT-LIPID)
Status: COMPLETED
Conditions: High Risk Atherosclerotic Cardiovascular Disease
Interventions: OTHER: Electronic Alert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Baska & I-gel for Ventilation of Female Patients During Minor Procedures
Status: UNKNOWN
Conditions: Medical Device Complication
Interventions: DEVICE: laryngeal mask insertion (Baska)|DEVICE: laryngeal mask insertion (I-gel )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Autologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa
Status: COMPLETED
Conditions: Retinitis Pigmentosa
Interventions: BIOLOGICAL: intravitreal injection of autologous bone marrow stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Human Serum Albumin in the Treatment of AD (Alzheimer Disease) Exploratory Clinical Trials
Status: RECRUITING
Conditions: Alzheimer's Disease (AD)
Interventions: DRUG: Recombinant Human Serum Albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: iOCT for Patients With Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DEVICE: intraoperative OCT|DEVICE: stand-alone OCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase II/III Clinical Study of R484iv (Ibandronic Acid) for Primary Osteoporosis
Status: COMPLETED
Conditions: Primary Osteoporosis
Interventions: DRUG: ibandronic acid 0.5mg|DRUG: RIS placebo|DRUG: 1.0mg ibandronic acid|DRUG: ibandronic acid placebo|DRUG: 2.5mg RIS|DIETARY_SUPPLEMENT: Calcium and Vitamine D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antimicrobial Efficacy of Nano-Based ICM on E.F
Status: RECRUITING
Conditions: Enterococcus Faecalis Infection|Endodontically Treated Teeth|Endodontic Disease
Interventions: OTHER: antimicrobial efficacy of nano based intracanal medications on Enterococcus faecalis count reduction in secondary endodontic infection cases.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy, Tolerability and Safety of Donepezil (Aricept) in Parkinson's Disease Patients With Dementia
Status: COMPLETED
Conditions: Dementia With Parkinson's Disease
Interventions: DRUG: ARICEPT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: An Observational Study to Assess Quality of Life and Satisfaction of Young Women (Aged 18-29) Following 6 (±1) Months Using Jaydess as Their Contraceptive Method
Status: COMPLETED
Conditions: Quality of Life
Interventions: DRUG: Levonorgestrel (Jaydess, BAY86-5028)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Evaluate Drug-drug Interactions Between DWN12088 and Pirfenidone or Nintedanib in Healthy Volunteers
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: DWN12088|DRUG: Pirfenidone|DRUG: Nintedanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Intravenous Acetaminophen for Small Bowel Obstruction
Status: ENROLLING_BY_INVITATION
Conditions: Small Bowel Obstruction
Interventions: DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of the Supervised and Home-Based Progressive Resistant Training in Female Total Knee Arthroplasty Patients
Status: COMPLETED
Conditions: Total Knee Arthroplasty
Interventions: PROCEDURE: Supervised progressive resistance training|PROCEDURE: Home-based progressive resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Three Methods for Best PEEP Determination Compared With PEEP Determination Guided by Adult Respiratory Distress Syndrome (ARDS) Network
Status: UNKNOWN
Conditions: ARDS
Interventions: OTHER: PEEP by Best oxygenation|OTHER: PEEP by Best Compliance|OTHER: PEEP by Esophageal pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Cevira® in Patients With Cervical Histologic High-grade Squamous Intraepithelial Lesions (HSIL)
Status: UNKNOWN
Conditions: Cervical Intraepithelial Neoplasia Grade 2/3
Interventions: COMBINATION_PRODUCT: Cevira®|COMBINATION_PRODUCT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Intranasal Administration of Niclosamide (UNI91103) in Adults With Asymptomatic or Mild COVID-19
Status: TERMINATED
Conditions: Covid19
Interventions: DRUG: Niclosamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Left Atrial Appendage Exclusion on Short-Term Clinical Outcomes and Long-Term Stroke Incidence
Status: COMPLETED
Conditions: Atrial Fibrillation|Thromboembolism|Cerebrovascular Accident
Interventions: PROCEDURE: Left Atrial Appendage Ligation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Impact of Vitamins and Minerals Supplementation on Neuropathy and Nephropathy Complications
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: vitamin and mineral supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Effects of the New Nordic Renal Diet in Patients With Moderate Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease(CKD)|Hyperphosphatemia|Blood Pressure
Interventions: OTHER: Intervention group; NNRD group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New MRI Methods Applied to Heart Failure With Preserved Ejection Fraction (HFpEF)
Status: UNKNOWN
Conditions: MRI Scans
Interventions: DRUG: Adenosine|DRUG: Regadenoson|DRUG: O-15 labeled radioactive water|DEVICE: MRI|DEVICE: PET Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Diagnostic Values of Galectin-3, Soluble ST2 and BNP in Predicting the Clinical Outcome of ST-Segment Elevation Myocardial Infarction Patients
Status: NOT_YET_RECRUITING
Conditions: ST Elevation Myocardial Infarction|HF - Heart Failure|Stable Angina
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Low Molecular Weight Heparin for Hemodialysis Anticoagulation
Status: COMPLETED
Conditions: End Stage Renal Failure on Dialysis
Interventions: DRUG: low molecular weight heparin (enoxaparin sodium)|DRUG: standard unfractionated heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Apatinib Plus SHR1210 in Advanced Mucosal Melanoma
Status: UNKNOWN
Conditions: Mucosal Melanoma|Advanced Cancer|Apatinib|SHR-1210
Interventions: DRUG: apatinib plus SHR-1210
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of the UDI-6 and the IIQ-7 Cutoff Scores in Urinary Incontinent Women
Status: COMPLETED
Conditions: Quality of Life|Urinary Incontinence,Stress|Urinary Incontinence
Interventions: DIAGNOSTIC_TEST: ICIQ-SF|DIAGNOSTIC_TEST: UDI-6|DIAGNOSTIC_TEST: IIQ-7
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nitrate Supplementation on Motor Unit Activity
Status: COMPLETED
Conditions: Dietary Supplements|Healthy
Interventions: DIETARY_SUPPLEMENT: Nitrate supplementation|DIETARY_SUPPLEMENT: Placebo supplementtaion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Attenuation Of Hemodynamic Response To Laryngoscopy. Role Of Dexmedetomidine. A Dose Finding Study
Status: COMPLETED
Conditions: Hemodynamic Instability|Tracheal Intubation|Dexmedetomidine
Interventions: DRUG: Normal saline|DRUG: Dexmedetomidine 0.5 microgram/kg|DRUG: Dexmedetomidine 0.75 microgram/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an On-Demand Humidifier on Neuromuscular Patients Requiring Mechanical Ventilation
Status: COMPLETED
Conditions: Neuromuscular Diseases
Interventions: DEVICE: On Demand Humidification system Mark 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Assess Abivertinib in Combination With Abiraterone in Metastatic Castration Resistant Prostate Cancer
Status: SUSPENDED
Conditions: Prostate Cancer|Prostate Cancer Metastatic
Interventions: DRUG: Abivertinib|DRUG: Abiraterone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Electrical Stimulation in Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DEVICE: Neuromuscular electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glucosamine Sulphate Versus Ginger in Non-Surgical Periodontal Therapy
Status: COMPLETED
Conditions: Periodontal Pocket
Interventions: DRUG: Glucosamine Sulfate|DRUG: Ginger Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Sacituzumab Govitecan in Patients With Advanced Thymic Epithelial Tumors
Status: RECRUITING
Conditions: Thymoma|Thymic Carcinoma
Interventions: DRUG: Sacituzumab govitecan-hziy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxford Acute Myocardial Infarction - Pressure-controlled Intermittent Coronary Sinus Occlusion
Status: COMPLETED
Conditions: ST Elevation Myocardial Infarction
Interventions: DEVICE: PICSO
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Photobiomodulation on Pain and Sexual Function in Women With Dyspareunia: Randomized Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: Dyspareunia|Pain|Sexual Dysfunction
Interventions: DEVICE: photobiomidulação|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Susceptibility-Guided Sequential Therapy for Helicobacter Pylori Infection
Status: RECRUITING
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: clarithromycin-sensitive(first-line)|DRUG: clarithromycin-resistant(first-line)|DRUG: empirical therapy group first-line|DRUG: levofloxacin-sensitive(rescue treatment)|DRUG: levofloxacin-resistant(rescue treatment)|DRUG: empirical therapy group rescue treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Recurrence Study
Status: UNKNOWN
Conditions: Acute Stroke|Transient Ischemic Attack
Interventions: DIAGNOSTIC_TEST: Corneal Confocal Imaging|DIAGNOSTIC_TEST: Magnetic resonance Imaging|OTHER: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy Study of Nab-paclitaxel Plus Gemcitabine in Chinese Patients With Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Neoplasms
Interventions: DRUG: nab-paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Limited Driving Pressure Ventilation and Conventional Mechanical Ventilation Strategies in Medical Intensive Care Patients With Acute Respiratory Failure
Status: COMPLETED
Conditions: on Invasive Mechanical Ventilation|ARDS|Respiratory Failure
Interventions: PROCEDURE: Limited driving pressure|PROCEDURE: Conventional mechanical ventilation strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Faricimab for High-frequent Aflibercept Treated Neovascular Age-related Macular Degeneration
Status: ACTIVE_NOT_RECRUITING
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: Aflibercept 40 MG/ML|DRUG: Faricimab 120 MG/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Nasal Oxygen Therapy to Reduce Postoperative Complications in Ankle Trauma Surgery in At-risk Patients: a Randomized Pilot Study.
Status: RECRUITING
Conditions: Ankle Fractures
Interventions: DRUG: Oxygen|OTHER: no oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anagrelide Retard in Essential Thrombocythemia
Status: COMPLETED
Conditions: Essential Thrombocythemia
Interventions: DRUG: Anagrelide retard|DRUG: Thromboreductin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Two-step Training Paradigm for Voluntary Control of the Peri-auricular Muscles
Status: COMPLETED
Conditions: Non-disabled Volunteers|Lacking Voluntary Control of Ear Muscles
Interventions: DEVICE: FastStart neuromuscular electrical stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: DURvalumab in Combination With S-488210/S-488211 vAccine in Non-muscle Invasive Bladder CancEr
Status: RECRUITING
Conditions: Bladder Cancer
Interventions: DRUG: Durvalumab|BIOLOGICAL: S-488210/S-488211
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Using SightSaver Visual Evoked Potential (VEP) for VEP Monitoring in Prone Spine Surgery
Status: COMPLETED
Conditions: Ischemic Optic Neuropathy
Interventions: DEVICE: VEP under TIVA|DEVICE: VEP under balanced anesth.|DRUG: Propofol|DRUG: Desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Comparison of Supraperiosteal Nerve Block With Opiate Analgesia in Alleviating the Pain of Toothache
Status: COMPLETED
Conditions: Toothache
Interventions: DRUG: hydrocodone/acetaminophen|DRUG: bupivacaine (supraperiosteal nerve block)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BIIB014 Phase 2a Monotherapy
Status: WITHDRAWN
Conditions: Parkinson's Disease
Interventions: DRUG: active drug (BIIB014) at 10, 30, 100, or 300 mg once daily.|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Immune Response of Caudally Administrated Tramadol In Pediatric Lower Abdominal Surgery
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: Bupivacaine|DRUG: Tramadol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Exhalation Valve on the Lack of Air and Exercise Tolerance in Patients With COPD
Status: UNKNOWN
Conditions: COPD
Interventions: DEVICE: CPET submaximal with EPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of RTB101 on Illness Associated With Respiratory Tract Infections in the Elderly
Status: WITHDRAWN
Conditions: Clinically Symptomatic Respiratory Illness
Interventions: DRUG: Dactolisib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of MOX/ALB Co-administration in SAC
Status: COMPLETED
Conditions: Trichuriasis|Ascariasis|Hookworm Infections
Interventions: DRUG: Moxidectin 2 mg Oral Tablet|DRUG: Albendazole 400 mg Oral Tablet|DRUG: Placebo MOX|DRUG: Placebo ALB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Intensive and Standard Training for Human Insulin Inhalation Powder (HIIP)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: LY041001 (HIIP)|DRUG: LY041001 (HIIP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Pain Palliation Benefit of Adding Custirsen to Docetaxel Retreatment or Cabazitaxel as Second Line Therapy in Men With Metastatic Castrate Resistant Prostate Cancer (mCRPC)
Status: TERMINATED
Conditions: Castrate-Resistant Prostate Cancer|Hormone Refractory Prostate Cancer
Interventions: DRUG: custirsen sodium|DRUG: isotonic, 0.9% sodium chloride|DRUG: docetaxel|DRUG: cabazitaxel|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Bevacizumab for Nonproliferative Diabetic Retinopathy
Status: UNKNOWN
Conditions: Non-proliferative Diabetic Retinopathy
Interventions: DRUG: Intravitreal Bevacizumab IVB|OTHER: Follow-up with regular examination for determination of DR progression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Hydroxycinnamates and Beta-glucans as a Dietary Tool Against Obesity (OBHEALTH)
Status: COMPLETED
Conditions: Overweight/Obesity|Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: Green coffee extract|DIETARY_SUPPLEMENT: Beta glucan|DIETARY_SUPPLEMENT: Green coffee + beta-glucan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate Immunogenicity and Safety of GSK Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine at 9 and 10 Years After Vaccine Administration and Assessment of Re-vaccination With 2 Additional Doses at 10 Years After Initial Vaccination, in Healthy Subjects Aged 60 Years of Age(YOA) and Older
Status: COMPLETED
Conditions: Herpes Zoster
Interventions: BIOLOGICAL: Herpes Zoster Vaccine GSK1437173A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Escalating Doses of INA03 Administered Intravenously as Single Agent in Adult Patients With Relapse/Refractory Acute Leukemia
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia Recurrent|Acute Lymphoblastic Leukemia, in Relapse|Acute Myeloid Leukemia, in Relapse|Acute Myeloid Leukaemia Recurrent|Mixed Phenotype Acute Leukemia
Interventions: DRUG: INA03 administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Xenogeneic Collagen Matrix or Palatal Connective Tissue Graft With a Coronally Advanced Flap in Class III Recessions
Status: COMPLETED
Conditions: Gingival Recession
Interventions: DEVICE: experimental: collagen matrix|OTHER: Active Comparator: autologous connective tissue graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: REducing the Risk of COgnitive DEcline ad Dementia in Patients With Subjective Cognitive Decline Through an Immersive Virtual Reality and Telemedicine-based Multi-component Intervention: the SCD-ReCODED Study
Status: NOT_YET_RECRUITING
Conditions: Subjective Cognitive Decline
Interventions: DEVICE: Multi-component Intervention (MC-I): VR Cognitive training and Psychoeducation on health and lifestyle|DEVICE: Cognitive-only intervention (CO-I): VR Cognitive training (+ Psychoeducation active control)|DEVICE: Active control intervention (AC-I): VR Cognitive active control + Psychoeducation active control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intensive Self-care on Glycemic Control in Outpatients With Type 2 Diabetes Mellitus: The Diabetes Care (D-CARE) Study
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Cardiovascular Diseases|Diabetes Mellitus
Interventions: BEHAVIORAL: Prochaska and DiClemente transtheorical model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 68Ga-RM2 for PET/CT of Gastrin Releasing Peptide Receptor (GRPr) Expression in Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: RADIATION: 68Ga-RM2 (RM2)|DEVICE: PET/CT Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Insights Into Tick-Borne Diseases: a Study From an Endemic Area of Northern Italy
Status: RECRUITING
Conditions: Tick-Borne Diseases
Interventions: DIAGNOSTIC_TEST: IgG and IgM search for specific Tick-Borne Patogens
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma
Status: RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma|Grade 3b Follicular Lymphoma|Primary Mediastinal (Thymic) Large B-Cell Lymphoma|Recurrent Diffuse Large B-Cell Lymphoma|Refractory Diffuse Large B-Cell Lymphoma|Transformed Follic Lymph to Diff Large B-Cell Lymphoma|Transformed Marg Zone Lymph to Diff Large B-Cell Lymphoma
Interventions: BIOLOGICAL: Axicabtagene Ciloleucel|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Cyclophosphamide|DRUG: Fludarabine|BIOLOGICAL: Lisocabtagene Maraleucel|BIOLOGICAL: Mosunetuzumab|OTHER: Patient Observation|DRUG: Polatuzumab Vedotin|PROCEDURE: Positron Emission Tomography|BIOLOGICAL: Tisagenlecleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of the Prostaglandin (Alprostadil) on Cerebral and Pulmonary Flow
Status: TERMINATED
Conditions: Congenital Heart Disease
Interventions: DRUG: Alprostadil 5 MCG Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ATI-450 Plus Methotrexate (MTX) vs MTX Alone in Patients With Moderate to Severe RA
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: ATI-450|DRUG: Placebo oral tablet|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Pharmacokinetic Profile of Tranexamic Acid, After Injection in a Knee Neo-articulation.
Status: COMPLETED
Conditions: Knee Prosthesis
Interventions: DRUG: Tranexamic Acid|DRUG: Adrenalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Effects of Acetyl-L-Carnitine and Myo/Chiro-Inositol in Patients With PCOS
Status: RECRUITING
Conditions: Infertility, Female|PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
Interventions: DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Oral Vitamin K for Warfarin Associated Coagulopathy
Status: COMPLETED
Conditions: Coagulation|Bleeding|Thrombosis
Interventions: DRUG: Phytonadione (Vitamin K1)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Escitalopram, Placebo and tDCS in Depression: a Non-inferiority Trial
Status: COMPLETED
Conditions: Major Depressive Disorder|Major Depressive Disorder, Recurrent, Unspecified|Major Depressive Disorder, Single Episode, Unspecified
Interventions: DRUG: Escitalopram oxalate|DEVICE: transcranial direct current stimulation|OTHER: Sham tDCS + Placebo Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Can Staging Magnetic Resonance Imaging (MRI) Features Prognosticate Patients Presenting With Endometrial Cancer?
Status: RECRUITING
Conditions: Endometrial Cancer|Endometrial Neoplasms
Interventions: OTHER: Radiomics: Analysis of textural features of imaging (MRI and Ultrasound)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Natural Orifice Translumenal Endoscopic Surgery (NOTES): Laparoscopic Assisted Transvaginal Ventral Hernia Repair
Status: UNKNOWN
Conditions: Umbilical Hernia|Ventral Hernia
Interventions: PROCEDURE: transvaginal NOTES ventral hernia repair
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Urticaria Facticia Treatment With Omalizumab (UFO)
Status: COMPLETED
Conditions: Symptomatic Dermographism
Interventions: DRUG: Omalizumab|DRUG: Omalizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple Dose-escalation Study of AMA0076 in Patients With Ocular Hypertension or Primary Open-angle Glaucoma
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension|Eye Disease
Interventions: DRUG: AMA0076|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of rhBNP on CMD in Patients With STEMI After PPCI
Status: NOT_YET_RECRUITING
Conditions: STEMI
Interventions: DRUG: recombinant human B-type natriuretic peptide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carbamazapine for Inherited Erythromelalgia Patients With NaV1.7 Mutations
Status: COMPLETED
Conditions: Erythromelalgia
Interventions: DRUG: Carbamazepine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Aggressive Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|DRUG: CHOP regimen|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: leucovorin calcium|DRUG: melphalan|DRUG: methotrexate|DRUG: methylprednisolone|DRUG: mitoxantrone hydrochloride|DRUG: prednisone|DRUG: therapeutic hydrocortisone|DRUG: vincristine sulfate|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Expanded Evaluation of the Survivorship Wellness Group Program in the Context of COVID-19 and Telehealth
Status: COMPLETED
Conditions: COVID-19 Infection|Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: OTHER: Survey Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hormone Therapy and Docetaxel or Hormone Therapy Alone in Treating Patients With Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: antiandrogen therapy|DRUG: docetaxel|DRUG: goserelin acetate|PROCEDURE: orchiectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medication Development for Protracted Abstinence in Alcoholism: CORT118335 Versus Placebo
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: DRUG: Miricorilant|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Conscious Sedation on Acute Stress
Status: COMPLETED
Conditions: Dental Anxiety|Dental Fear|Tooth Extraction Status Nos
Interventions: PROCEDURE: Procedures of wisdom tooth removal surgery under conscious sedation|PROCEDURE: Procedures of wisdom tooth removal surgery under local anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Functional Oral-Pharyngeal Rehabilitation of Patients With Dysphagia Using Ice-chips, a Prospective Randomized Study
Status: UNKNOWN
Conditions: Post Extubation Dysphagia
Interventions: OTHER: Ice chips
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Multicenter Study of 074-6751 Lotion in Subjects With Moderate Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DEVICE: 074-6751 Lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Social Media Usage on Pain Catastrophizing and Disease Impact in Female Patients With Fibromyalgia Syndrome
Status: NOT_YET_RECRUITING
Conditions: Fibromyalgia
Interventions: OTHER: Pain catastrophizing scale|OTHER: Beck Anxiety Inventory|OTHER: Social Media Use Integration Scale|OTHER: Fibromyalgia Impact Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exercise Training and Kidney Transplantation
Status: COMPLETED
Conditions: Solid Organ Transplant Rejection|Chronic Kidney Failure|Quality of Life|Inflammation|Muscle Weakness
Interventions: OTHER: Exercise training|OTHER: Continue exercising|OTHER: Discontinue exercising
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Visceral Adiposity and Diabetes: Translating Form to Function Using Imaging
Status: COMPLETED
Conditions: Obesity, Visceral
Interventions: DRUG: [U-13C3] glycerol|DRUG: Empagliflozin|DRUG: Placebo (for Empagliflozin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Trial in Sleep Laboratory Setting to Compare the Physiology of Night Time Bladder Function in Subjects With Overactive Bladder (OAB) Versus Subjects That Have Insomnia and Healthy Normal Subjects
Status: COMPLETED
Conditions: Bladder Function
Interventions: PROCEDURE: cystometry|PROCEDURE: polysomnography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Analgesic Effect of Illiohypogastic & Ilioinguinal Nerve Block in TAVR - TF (Prospective Randomized Study)
Status: RECRUITING
Conditions: Anesthesia, Local
Interventions: DRUG: Lidocaine|DRUG: Bupivacain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Topical Steroid for Prevention of Chronic Lung Disease in Extremely Premature Infants.
Status: UNKNOWN
Conditions: Bronchopulmonary Dysplasia
Interventions: DRUG: Infasurf|DRUG: Pulmicort|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics of CLG561 in Patients With Advanced Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Age-related Macular Degeneration
Interventions: DRUG: CLG561
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prevention of Vision Loss in Patients With Age-Related Macular Degeneration (AMD) by Intravitreal Injection of Bevacizumab and Ranibizumab
Status: UNKNOWN
Conditions: Age-Related Neovascular Macular Degeneration
Interventions: DRUG: bevacizumab|DRUG: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Simvastatin in The Epithelial-Mesenchymal Transition Process of Breast Cancer
Status: RECRUITING
Conditions: Triple Negative Breast Cancer|Chemotherapy Effect|Simvastatin Adverse Reaction
Interventions: DRUG: Simvastatin 40mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Buerger's Disease
Status: COMPLETED
Conditions: Buerger's Disease
Interventions: BIOLOGICAL: RNL-Vascostem®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Pharmacokinetic and Pharmacodynamic Effects of "Tobacco-Free" Oral Nicotine Pouches in Smokers
Status: RECRUITING
Conditions: Nicotine Withdrawal|Nicotine Addiction|Drug Effect
Interventions: OTHER: Nicotine|OTHER: Cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Noninvasive Brain Stimulation for Treating Carpal Tunnel Syndrome
Status: RECRUITING
Conditions: Chronic Pain|Carpal Tunnel Syndrome
Interventions: DEVICE: transcranial Direct Current Stimulation (tDCS)|DEVICE: Transcranial Ultrasound (TUS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial for the Investigational Drug (PB-201) in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type2 Diabetes Mellitus
Interventions: DRUG: glucokinase activator|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CO2 Clearance During Noninvasive Ventilation (NIV)
Status: UNKNOWN
Conditions: Acute Hypercapnic Respiratory Failure
Interventions: DEVICE: DiMax Zero Total face mask "R",|DEVICE: traditional face mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sirolimus, Tacrolimus, and Antithymocyte Globulin in Preventing Graft-Versus-Host Disease in Patients With Hematologic Cancer Who Are Undergoing Donor Stem Cell Transplant
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: BIOLOGICAL: rituximab|DRUG: busulfan|DRUG: carmustine|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: etoposide|DRUG: fludarabine phosphate|DRUG: melphalan|RADIATION: total body irradiation (TBI)|DRUG: anti-thymocyte globulin IV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Concurrent Nab-P/Carboplatin and Thoracic Radiotherapy in Squamous Cell Lung Cancer
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung|Carcinoma, Squamous Cell
Interventions: DRUG: Paclitaxel for Injection（Albumin Bound）|DRUG: carboplatin|RADIATION: thoracic radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adherence to Electrical Glossal In Situ Stimulation for Sleep Apnea (AEGIS Study)
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: eXciteOSA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of SNX-1012 in the Treatment of Oral Mucositis
Status: COMPLETED
Conditions: Stomatitis|Oral Mucositis
Interventions: DRUG: SNX-1012 (meclocycline sulfosalicylate)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Face Scanning on Accuracy of Dental Implant Placement in Fixed Implant Supported Maxillary Prostheses
Status: RECRUITING
Conditions: Computer-Assisted Surgery
Interventions: DEVICE: Dual scan protocol|DEVICE: triple scan protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture Versus Titrated Morphine in Patients With Renal Colic
Status: COMPLETED
Conditions: Renal Colic
Interventions: PROCEDURE: Traditional Acupuncture Session|DRUG: Morphine Titration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Estrogen, Probiotics and Vaginal Health to Prevent HIV Infection in ACB Women
Status: COMPLETED
Conditions: HIV-1-infection|Bacterial Vaginoses
Interventions: DRUG: Estring Vaginal Ring|OTHER: RepHresh Pro-B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Exploratory PET-study of Deposition, Disposition and Brain Uptake of [11C]Nicotine After Inhalation of 2 Nicotine Formulations Via the myBluTM E-cigarette in Smokers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: myBluTM Formulation 1|OTHER: myBluTM Formulation 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Use of Fluorescent Imaging for Intraoperative Cholangiogram During Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Cholelithiasis|Cholecystitis|Pancreatitis Biliary|Colic of Gallbladder Without Mention of Cholecystitis
Interventions: DRUG: Indocyanine Green (ICG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Placebo-controlled Pilot Trial of Prebiotics+Glutamine in HIV Infection
Status: COMPLETED
Conditions: HIV
Interventions: DIETARY_SUPPLEMENT: Prebiotics+Glutamine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus
Status: COMPLETED
Conditions: Uremic Pruritus
Interventions: DRUG: Nalbuphine HCL ER
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Semaglutide on Taste, Tongue Tissue Transcriptome, Gastric Emptying and Central Neural Response in Women With PCOS and Obesity
Status: COMPLETED
Conditions: PCOS|Semaglutide|Taste, Altered|Tongue Tissue Transcriptome|Gastric Emptying|Central Neural Response
Interventions: DRUG: Semaglutide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Open Label Randomized Multicenter to Assess Efficacy & Tolerability of Ofatumumab 20mg vs. First Line DMT in RMS
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: Ofatumumab|DRUG: First line DMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lateral Cord Stimulation as a New Treatment for Refractory Spastic Cerebral Palsy
Status: NOT_YET_RECRUITING
Conditions: Cerebral Palsy|Spasticity
Interventions: DEVICE: Lateral spinal cord surgical implant of electrodes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective rAndomized sTudy efficaCy tHree-dimensional rEconstructions Segmentectomy
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer|Lung; Node
Interventions: DIAGNOSTIC_TEST: CT scans 2D Reconstruction|DIAGNOSTIC_TEST: CT scans 2D plus 3D Reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid vs. Benzodiazepine-based Sedation for Mechanically Ventilated Patients in the Internal Medicine Ward
Status: RECRUITING
Conditions: Mechanically Ventilated Patients
Interventions: DRUG: fentanyl-based sedation|DRUG: midazolam-based sedation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EUFURO - EUS-based Follow-Up on R0-resected Patients for Esophageal, Gastric and Pancreatic Cancer
Status: UNKNOWN
Conditions: Esophageal Cancer|Stomach Cancer|Pancreatic Cancer
Interventions: BEHAVIORAL: standard follow-up|PROCEDURE: PET/CT and EUS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Erdafitinib and Abiraterone Acetate or Enzalutamide in Treating Patients With Double Negative Prostate Cancer
Status: TERMINATED
Conditions: Castration-Resistant Prostate Carcinoma|Double-Negative Prostate Carcinoma|Metastatic Prostate Carcinoma|Prostate Adenocarcinoma|Stage IV Prostate Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8|Stage IVB Prostate Cancer AJCC v8
Interventions: DRUG: Abiraterone Acetate|DRUG: Enzalutamide|DRUG: Erdafitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Imatinib-associated Severe Skin Rash in Patients With Gastrointestinal Stromal Tumor
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumor(GIST)
Interventions: DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT