pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Neoadjuvant Chemotherapy in HER2 Positive Breast Cancer, TRAIN-2
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|HER2 Positive
Interventions: DRUG: PTC+Pertuzumab|DRUG: FEC-T+Pertuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study Of Tofacitinib Versus Tumor Necrosis Factor (TNF) Inhibitor In Subjects With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: tofacitinib|DRUG: tofacitinib|BIOLOGICAL: adalimumab|BIOLOGICAL: etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Physician's Choice Chemotherapy in PD-(L)1-refractory, Relapsed or Refractory Classical Hodgkin Lymphoma (MK-4280A-008)
Status: RECRUITING
Conditions: Hodgkin Lymphoma
Interventions: BIOLOGICAL: favezelimab/pembrolizumab|DRUG: bendamustine|DRUG: gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Treatment With Capecitabine and Immunotherapy Versus Immunotherapy Alone in Advanced Renal Cell Carcinoma
Status: TERMINATED
Conditions: Renal Cell Cancer
Interventions: DRUG: Capecitabine, Interferon, Interleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Posterior Wall And Left Atrial Appendage Empiric Electrical Isolation for Non-Paroxysmal Atrial Fibrillation
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risk and Clinical Consequences of Low Count Monoclonal B-cell Lymphocytosis (LC MBL)
Status: NOT_YET_RECRUITING
Conditions: Monoclonal B-Cell Lymphocytosis|Chronic Lymphocytic Leukemia|Infections|Cancers|Cardiovascular Diseases|Alzheimer Disease|Dementia|Autoimmune Diseases|Parkinson Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of tDCS Paired With Cognitive Training on Brain Networks Associated With Alcohol Use Disorder in Veterans
Status: RECRUITING
Conditions: Alcohol Use Disorder
Interventions: DEVICE: Active Transcranial Direct Current Stimulation (tDCS)|DEVICE: Sham Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Agaricus Bisporus and Influenza Vaccination Response
Status: RECRUITING
Conditions: Immune Response
Interventions: BIOLOGICAL: Influenza vaccine|DIETARY_SUPPLEMENT: Agaricus bisporus capsules|DIETARY_SUPPLEMENT: Control capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose-finding Study: Popliteal Sciatic Nerve Block in Patients Undergoing Diabetic Foot Surgery
Status: RECRUITING
Conditions: Diabetic Foot|Diabetic Neuropathies
Interventions: OTHER: Maintain the concentration of ropivacaine as same as those used in the previous participant|OTHER: Decrease the ropivacaine concentration by 0.05% from the concentration used in the previous participant|OTHER: Increase the ropivacaine concentration by 0.05% from the concentration used in the previous participant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of SHP639 Eye Drops in Adults With High Eye Pressure or Primary Open-angle Glaucoma
Status: COMPLETED
Conditions: Primary Open-angle Glaucoma (POAG)|Ocular Hypertension
Interventions: DRUG: SHP639 (n=60)|DRUG: Placebo Comparator (n=24)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COMPARISON OF THE EFFECTS OF TELEREHABILITATION AND FACE-TO-FACE SPINAL STABILIZATION TRAININGS ON GAIT BIOMECHANICS, BALANCE AND JOINT POSITION SENSE IN TRANSTIBIAL AMPUTEES: A RANDOMIZED CONTROLLED, SINGLE BLIND STUDY
Status: RECRUITING
Conditions: Amputation
Interventions: OTHER: Spinal stabilization training through telerehabilitation|OTHER: Spinal stabilization training face-to-face
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Warm and Humidified vs Cold and Dry Carbon Dioxide (CO2) Pneumoperitoneum
Status: WITHDRAWN
Conditions: Pneumoperitoneum
Interventions: DEVICE: Cold and dry CO2 pneumoperitoneum|DEVICE: Warm and humidified CO2 pneumoperitoneum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Body Mass Index and Age Correlate With Antioxidant Supplementation Effects on Sperm Quality
Status: COMPLETED
Conditions: Male Infertility
Interventions: DIETARY_SUPPLEMENT: Proxeed|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Molecular Detection Of Efflux Pump and Virulence Factors Genes in Pseudomonas Aeruginosa
Status: RECRUITING
Conditions: Pseudomonas Aeruginosa
Interventions: DIAGNOSTIC_TEST: culture on cetrimide agar|DIAGNOSTIC_TEST: Staining with Gram stain|DIAGNOSTIC_TEST: Antibiotic sensitivity testing|DIAGNOSTIC_TEST: Molecular detection to efflux genes and some virulence genes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Electronic Cigarettes as a Harm Reduction Strategy in Individuals With Substance Use Disorder
Status: RECRUITING
Conditions: Cigarette Smoking|Addiction|E Cig Use
Interventions: DEVICE: E cigarettes|OTHER: Nicotine Replacement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyaluronan-enriched Medium and Euploid Blastocyst Transfers
Status: RECRUITING
Conditions: Infertility|Implantation Rate|Clinical Pregnancy Rate|Live Birth Rate|Blastocysts|FET
Interventions: DRUG: EmbryoGlue Medium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Impact of Skin to Skin Contact on Maternal Satisfaction, Pain Scores, and Narcotic Usage After Cesarean Delivery
Status: COMPLETED
Conditions: Skin to Skin Contact in Cesarean Deliveries
Interventions: OTHER: skin to skin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Early Feasibility Study of the AccuCinch® Ventricular Restoration System in Patients With Prior Mitral Valve Intervention (PMVI) and Recurrent Mitral Regurgitation
Status: COMPLETED
Conditions: Heart Failure|Cardiomyopathy, Dilated
Interventions: DEVICE: AccuCinch® Ventricular Restoration System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: REMAP Trial for Optimizing Surgical Outcomes at UPMC
Status: TERMINATED
Conditions: Aging
Interventions: DRUG: Metformin ER|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Influence of the A118G Polymorphism in the mu Opioid Receptor Gene (OPRM1) on Effects of GSK1521498 and Naltrexone on Physiological and Behavioural Markers of Brain Function in Healthy Social Drinkers
Status: COMPLETED
Conditions: Alcoholism
Interventions: DRUG: GSK1521498|DRUG: Naltrexone (NTX)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on Lot-to-lot Consistency and Immune Persistence of Three Commercial Batches of PPSV23
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: 23 Valent Pneumococcal Polysaccharide Vaccine (lot 1)|BIOLOGICAL: 23 Valent Pneumococcal Polysaccharide Vaccine (lot 2)|BIOLOGICAL: 23 Valent Pneumococcal Polysaccharide Vaccine (lot 3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lcr35 for Children With Functional Constipation
Status: COMPLETED
Conditions: Constipation
Interventions: DIETARY_SUPPLEMENT: Lactobacillus casei rhamnosus Lcr35|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of OnabotulinumtoxinA in Forehead and Glabellar Facial Rhytides
Status: COMPLETED
Conditions: Forehead Rhytides|Glabellar Rhytides
Interventions: BIOLOGICAL: OnabotulinumtoxinA|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial on Efficacy and Safety of Pritelivir Tablets for Treatment of Acyclovir-resistant Mucocutaneous HSV (Herpes Simplex Virus) Infections in Immunocompromised Subjects
Status: RECRUITING
Conditions: HSV Infection
Interventions: DRUG: Pritelivir|DRUG: Investigator's choice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Group Treatment for Obsessive-compulsive Disorder in Youth
Status: ACTIVE_NOT_RECRUITING
Conditions: Obsessive-Compulsive Disorder|Cognitive Behavioral Therapy|Adolescent
Interventions: OTHER: Cognitive behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Safety, Pharmacokinetics and Pharmacodynamics of PG-102(MG12) in Healthy Volunteers
Status: RECRUITING
Conditions: Healthy|Overweight
Interventions: DRUG: PG-102(MG12)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Diadynamic in Association With a Manual Therapy Program for Patients With Impingement Syndrome
Status: COMPLETED
Conditions: Shoulder Impingement Syndrome
Interventions: OTHER: manual therapy|DEVICE: diadynamic current
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Yoga and MBSR for TTH
Status: UNKNOWN
Conditions: Tension-Type Headache
Interventions: BEHAVIORAL: Iyengar Yoga|BEHAVIORAL: Mindfulness-based stress reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dual-Hormone Closed-Loop Glucose Control in Adolescents With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Glucagon|DEVICE: Closed-loop System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vitamin C for the Prevention of UTI in Women Who Undergo Elective GYN Surgeries
Status: WITHDRAWN
Conditions: Catheter-Associated Urinary Tract Infection, Ascorbic Acid
Interventions: DRUG: Ascorbic Acid 1000 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Yoga Therapy and Oppositional Defiant Disorder Behaviors
Status: RECRUITING
Conditions: Oppositional Defiant Disorder in Children|Oppositional Defiant Disorder
Interventions: OTHER: Yoga Therapy|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gabapentin Enacarbil (GSK1838262) Adult Restless Leg Syndrome (RLS) Post Marketing Commitment Study
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DRUG: GSK1838262 600 mg|DRUG: GSK1838262 450 mg|DRUG: GSK1838262 300 mg|DRUG: GSK1838262 Placebo match
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Sorting of Apoptotic Spermatozoa on the Outcome of Assisted Reproduction
Status: COMPLETED
Conditions: Male Infertility
Interventions: PROCEDURE: Staining of spermatozoa with the YoPro dye and sorting of the stained spermatozoa with FACS|PROCEDURE: Swim-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Hydroxychloroquine and Aldesleukin in Renal Cell Carcinoma Patients (RCC)
Status: COMPLETED
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: Hydroxychloroquine|DRUG: IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of a Monthly Replacement Silicone Hydrogel Lens
Status: COMPLETED
Conditions: Refractive Errors
Interventions: DEVICE: LID014341 contact lenses|DEVICE: Comfilcon A contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prospective Observational Study to Predict Severe Oral Mucositis Associated With Chemoradiotherapy in Nasopharyngeal Carcinoma Based on Deep Learning
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma|Oral Mucositis
Interventions: OTHER: observational group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Demonstrate Improvement in Symptoms of Constipation in Subjects That Require Around-the-clock Opioid Pain Killer Therapy
Status: COMPLETED
Conditions: Pain|Constipation
Interventions: DRUG: oxycodone/naloxone prolonged release (OXN PR) tablets|DRUG: oxycodone prolonged release (OxyPR) tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multicentric Open-label Study of Switch From Abacavir/Lamivudine Fixed Dose Combination Plus Nevirapine to Abacavir/Lamivudine/Dolutegravir in Virologically Suppressed HIV-1 Infected Adults (SWAD)
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: Abacavir/Lamivudine/Dolutegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Instrumentation Effectiveness of Modified, Area-Specific Hand Scalers During Non-Surgical Periodontal Therapy
Status: COMPLETED
Conditions: Periodontal Diseases|Dental Diseases
Interventions: PROCEDURE: Scaling and root planing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Moderate Alcohol Consumption, Fat and Carbohydrate Metabolism and Insulin Sensitivity
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: A|DIETARY_SUPPLEMENT: B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Pneumoperitoneum on Intracranial Pressure in Pediatric Laparoscopic Surgery: Ultrasonographic Measurement of Optic Nerve Sheath Diameter
Status: COMPLETED
Conditions: Intracranial Pressure
Interventions: DEVICE: ultrasonographic measurement of optic nerve sheath diameter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Pharmacokinetics Study of Multiple Ascending Doses of BTA-C585 in Healthy Volunteers
Status: COMPLETED
Conditions: Pharmacokinetics|Healthy Volunteers
Interventions: DRUG: BTA-C585 oral capsules|DRUG: BTA-C585 matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Gastric Plication Using the POSE2.0 Technique for Management of Fatty Liver Disease
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease|Obesity
Interventions: PROCEDURE: POSE2.0 procedure|BEHAVIORAL: Life style and behavioral intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Therapeutic Effect of Betaine in Syringomyelia
Status: RECRUITING
Conditions: Syringomyelia
Interventions: DRUG: Betaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: INTRINSIC RV - Inhibition of Unnecessary RV Pacing With AV Search Hysteresis in ICDs
Status: COMPLETED
Conditions: Tachycardia
Interventions: DEVICE: Implantable Cardioverter Defibrillator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of the Swedish Internet-based Individualised Active Communication Education (I-ACE) in FTU
Status: ACTIVE_NOT_RECRUITING
Conditions: Hearing Impairment
Interventions: BEHAVIORAL: Individualised Active Communication Education (I-ACE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Onabotulinumtoxin A (Botox) in Pediatric Patients Experiencing Migraines: A Study in the Pediatric Pain Population
Status: COMPLETED
Conditions: Migraine Disorders|Headache, Migraine|Pediatrics
Interventions: DRUG: OnabotulinumtoxinA|OTHER: Placebo (Saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Mucoadhesive Tacrolimus Patch on Caspase-3 Inducing Apoptosis in Oral Lichen Planus
Status: COMPLETED
Conditions: Oral Lichen Planus
Interventions: DRUG: Corticosteroid Topical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: No Operation After Short Course Radiotherapy Followed By Consolidation Chemotherapy In Locally Advanced Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer
Interventions: DRUG: Oxaliplatin|DRUG: 5-Fluoracil|DRUG: Leucovorin|DRUG: Capecitabine|RADIATION: 5x5 Gy|BEHAVIORAL: Quality of Life Questionnaires|PROCEDURE: DRE/ Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Salbutamol Administration by Nebulizer Versus Metered Dose Inhaler With Spacer in Asthma in Children
Status: COMPLETED
Conditions: Bronchial Asthma
Interventions: DEVICE: Nebulizer|DRUG: Salbutamol|DEVICE: Metered dose inhaler and spacer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of MGCD265 Given With Erlotinib or Docetaxel in Subjects With Advanced Malignancies or Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Advanced Malignancies, Non-small Cell Lung Cancer
Interventions: DRUG: MGCD265+erlotinib|DRUG: MGCD265+docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Nasopharyngeal Carriage of Streptococcus Pneumoniae in Healthy Children of 12-18 Months in 6 Cities, China
Status: COMPLETED
Conditions: Streptococcus Pneumoniae Infections
Interventions: OTHER: Nasopharyngeal swab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Electrical Nerve Stimulation for Overactive Bladder a Comparison of Treatments
Status: UNKNOWN
Conditions: Overactive Bladder|Urge Urinary Incontinence
Interventions: DEVICE: PTNS (Percutaneous Tibial Nerve Stimulation|DEVICE: TENS (Transcutaneous Electrical Nerve Stimulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changing Health and Lifestyle Behaviors of Offspring Following Maternal Bariatric Surgery
Status: RECRUITING
Conditions: Obesity, Childhood
Interventions: BEHAVIORAL: HALO|BEHAVIORAL: Enhanced Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MARt-Depression Trial
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: Soterix Medical tDCS mini-Clinical Trials system (mini-CT)|BEHAVIORAL: Computerized CBT (cCBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telemonitoring and Protocolized Case Management for Hypertensive Community Dwelling Seniors With Complex Care Needs
Status: COMPLETED
Conditions: Hypertension
Interventions: DEVICE: Telemonitoring|OTHER: Case Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Anthrax Vaccine Clinical Trial to Assess Dose Reduction and Route Change
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Anthrax Vaccine Adsorbed|BIOLOGICAL: Saline injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Investigation of Mesenchymal Stem Cell Therapy for the Treatment of Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: BIOLOGICAL: BMAC injection|BIOLOGICAL: PRP injection|DEVICE: Gel-One® hyaluronate injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intravenous Anesthetics on Fear Learning and Memory
Status: COMPLETED
Conditions: Phobias
Interventions: DRUG: Placebos|DRUG: Propofol 0.45mcg/mL|DRUG: Propofol 0.90mcg/mL|DRUG: Thiopental 1.5mcg/mL|DRUG: Thiopental 3mcg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Endoscopic Intraventricular Hematoma Evacuation Surgery Versus EVD for IVH
Status: UNKNOWN
Conditions: Intraventricular Hemorrhage, Endoscopic Intraventricular Evacuation Surgery, Extraventricular Drainage
Interventions: PROCEDURE: endoscopic intraventricular evacuation surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate UB-612 COVID-19 Vaccine in Adolescent, Younger and Elderly Adult Volunteers
Status: TERMINATED
Conditions: COVID-19
Interventions: BIOLOGICAL: UB-612|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Transcutaneous Auricular Neurostimulation on Cognitive Performance in a Laboratory Model of Acute Stress Reaction
Status: NOT_YET_RECRUITING
Conditions: Acute Stress Reaction|Cognitive Performance
Interventions: DEVICE: Sparrow Hawk (Active)|DEVICE: Sparrow Hawk (Sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carbetocin Versus Oxytocin and Ergometrine for the Prevention of Postpartum Haemorrhage Following Caesarean Section
Status: COMPLETED
Conditions: Bleeding|Anemia
Interventions: DRUG: Pabal 100 mcg iv infusion over 1 minute given after delivery of fetal head|DRUG: Oxytocin 5 IU iv infusion and Methtergine 0.2 mg iv
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Safety and Effectiveness of Ustekinumab in Patients With Moderate to Severe Active Crohn's Disease Who Have Been Previously Treated With Anti-TNF Therapy
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: Placebo (IP)|DRUG: Ustekinumab 1mg/kg (IP)|DRUG: Ustekinumab 3 mg/kg (IP)|DRUG: Ustekinumab 6 mg/kg (IP)|DRUG: Placebo IV - Responder - Placebo SC (MP)|DRUG: Placebo IV - Nonresponder - Ustekinumab 270/90 mg SC (MP)|DRUG: Ustekinumab IV - Responder - Placebo SC (MP)|DRUG: Ustekinumab IV - Responder - Ustekinumab 90mg SC (MP)|DRUG: Ustekinumab IV - Nonresponder - Placebo SC (MP)|DRUG: Ustekinumab IV - Nonresponder - Ustekinumab 90mg SC (MP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II, Single Arm Study of BGJ398 in Patients With Advanced Cholangiocarcinoma
Status: TERMINATED
Conditions: Advanced Cholangiocarcinoma|FGFR2 Gene Mutation
Interventions: DRUG: BGJ398 (infigratinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiopulmonary Bypass (CPB) Pumps and Blood Activation
Status: UNKNOWN
Conditions: Cardiopulmonary Bypass|Coronary Artery Disease
Interventions: DEVICE: pumps used for cardiopulmonary bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Study on a Quadrivalent Meningococcal Conjugate Vaccine (MenACYW Conjugate Vaccine) Compared to Two Meningococcal Reference Vaccines in European Toddlers
Status: COMPLETED
Conditions: Meningococcal Immunisation (Healthy Volunteers)
Interventions: BIOLOGICAL: Meningococcal polysaccharide (serogroups A, C, Y, and W) tetanus toxoid Conjugate vaccine|BIOLOGICAL: Meningococcal polysaccharide group A, C, W-135 and Y Conjugate vaccine|BIOLOGICAL: Meningococcal group C polysaccharide Conjugate vaccine adsorbed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Personalized Tumour Vaccines and a PD-L1 Blocker in Patients With Surgically Resected Pancreatic Adenocarcino
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Adebrelimab|DRUG: mRNA tumor vaccines
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-Dose Melphalan With or Without Radiolabeled Monoclonal Antibody in Treating Patients With Multiple Myeloma Undergoing an Autologous Stem Cell Transplant
Status: TERMINATED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: melphalan|PROCEDURE: autologous hematopoietic stem cell transplantation|RADIATION: yttrium Y 90 anti-CD66 monoclonal antibody BW 250/183
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bending Adolescent Depression Trajectories Through Personalized Prevention
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Interpersonal Psychotherapy- Adolescent Skills Training|BEHAVIORAL: Coping with Stress
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SSRI Study for Functional Dyspepsia (SS)
Status: COMPLETED
Conditions: Dyspepsia|Anxiety|Depression
Interventions: DRUG: Escitalopram|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Gamma-cyclodextrin on the Bioavailability of Berberine
Status: NOT_YET_RECRUITING
Conditions: Drug Absorption
Interventions: COMBINATION_PRODUCT: Berberine incorporated in gamma cyclodextrin|DIETARY_SUPPLEMENT: Berberine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Arimidex/Tamoxifen Neo Adjuvant Study in Premenopausal Patients With Breast Cancer Under Anti Hormonal Treatment
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Tamoxifen|DRUG: Anastrazole (Arimidex)|DRUG: Goserelin acetate (Zoladex)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Casein Phosphopeptide Amorphous Calcium Phosphate on Affected Dentine
Status: UNKNOWN
Conditions: Caries,Dental
Interventions: DRUG: Casein phosphopeptide amorphous calcium phosphate|PROCEDURE: Atraumatic restorative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Edoxaban in Thoracoscopic Ablation
Status: COMPLETED
Conditions: Atrial Fibrillation|Anticoagulants and Bleeding Disorders
Interventions: DRUG: Edoxaban|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Low-volume Preparation in the Elderly: Oral Sulfate Solution
Status: COMPLETED
Conditions: Bowel Preparation
Interventions: OTHER: low-volume preparation, oral sulfate solution|OTHER: large-volume preparation, 4L polyethylene glycol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Effects of Sacubitril-Valsartan vs Enalapril on Left Ventricular Remodeling in ST-elevation Myocardial Infarction
Status: NOT_YET_RECRUITING
Conditions: STEMI
Interventions: DRUG: Sacubitril-Valsartan|DRUG: Enalapril|DRUG: Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-finding Gluten Challenge Trial in Nonceliac Gluten-sensitivity
Status: UNKNOWN
Conditions: Nonceliac Gluten Sensitivity
Interventions: DIAGNOSTIC_TEST: Gluten or placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Effects of a L.Reuteri Strain on Markers of Inflammation, Cardiovascular Risk and Fatty Liver Disease
Status: COMPLETED
Conditions: Metabolic Syndrome X
Interventions: DIETARY_SUPPLEMENT: Lactobacillus spp|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pneumatic Compression Device for the Treatment of Lymphedema in Patients With Stage II-IV Head and Neck Cancer After Chemoradiation
Status: WITHDRAWN
Conditions: Clinical Stage II HPV-Mediated (p16-pos) Oropharyngeal Carcinoma|Clinical Stage III HPV-Mediated (p16-pos) Oropharyngeal Carcinoma|Clinical Stage IV HPV-Mediated (p16-pos)Oropharyngeal Carcinoma|Head and Neck Carcinoma|Stage II Hypopharyngeal Carcinoma AJCC v8|Stage II Laryngeal Cancer AJCC v8|Stage II Lip and Oral Cavity Cancer AJCC v8|Stage II Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage III Hypopharyngeal Carcinoma AJCC v8|Stage III Laryngeal Cancer AJCC v8|Stage III Lip and Oral Cavity Cancer AJCC v8|Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IV Hypopharyngeal Carcinoma AJCC v8|Stage IV Laryngeal Cancer AJCC v8|Stage IV Lip and Oral Cavity Cancer AJCC v8|Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Interventions: OTHER: Best Practice|OTHER: Consensus Auditory-Perceptual Evaluation of Voice|PROCEDURE: Diagnostic Imaging|OTHER: Lymphedema Management|PROCEDURE: Modified Barium Swallow|PROCEDURE: Nasopharyngeal Laryngoscopy|DEVICE: Pneumatic Compression Therapy|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|OTHER: Voice Handicap Index-10
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety & Effectiveness of Spinal Sealant
Status: COMPLETED
Conditions: Cerebrospinal Fluid Leakage, Subdural
Interventions: DEVICE: Spinal Sealant|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Rx Milk Study of Donor Milk Supplementation to Improve Breastfeeding Outcomes
Status: COMPLETED
Conditions: Breastfeeding Duration|Exclusive Breastfeeding|Donor Milk Supplementation
Interventions: OTHER: Donor Milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Development and Efficiency Evaluation of a Respiratory Disease Pandemics Preparedness Training Program for Pre-Hospital Emergency Healthcare Workers
Status: COMPLETED
Conditions: During the Pandemic Process the Focus is on Developing a Training Program
Interventions: BEHAVIORAL: Pandemic preparedness via video|BEHAVIORAL: Pandemic preparedness via classical method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Bilastine Updosing in Chronic Spontaneous Urticaria
Status: COMPLETED
Conditions: Chronic Urticaria
Interventions: DRUG: Bilastine|DRUG: Bilastine|DRUG: Bilastin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Dosage Regimens of Methocarbamol/Paracetamol in Acute Non-specific Low Back Pain. MioPain Study
Status: RECRUITING
Conditions: Low Back Pain
Interventions: DRUG: 380 mg/300 mg comprimidos metocarbamol/paracetamol - 4 times daily|DRUG: 380 mg/300 mg comprimidos metocarbamol/paracetamol - 6 times daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anodal tDCS in Chronic Migraine With Medication Overuse
Status: COMPLETED
Conditions: Chronic Migraine|Medication Overuse Headache
Interventions: DEVICE: Transcranial direct current stimulation (tDCS) group|DEVICE: Sham group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Tolerability Study of Zerenex (Ferric Citrate) in Patients With End-Stage Renal Disease (ESRD)
Status: COMPLETED
Conditions: Hyperphosphatemia|End-stage Renal Disease
Interventions: DRUG: ferric citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation Of Bioabsorbable Screws In Pediatric Orthopedic Surgery
Status: RECRUITING
Conditions: Pediatric|Fracture|Orthopedic Devices Associated With Misadventures, Surgical Instruments, Materials and Devices (Including Sutures)|Patient Satisfaction
Interventions: DEVICE: Bioabsorbable Screw|DEVICE: Metal/Titanium Screw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of Visual Acuity in Contact Lens Wearers After Instillation of Investigational Lubricating Eye Drops
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DRUG: Blink® Tears eye drops in a multidose bottle|DRUG: Preservative-free investigational lubricating eye drops in a Novelia® eyedropper
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: APG-2575 in Combination With Novel Therapeutic Regimens in Subjects With Relapsed or Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma|Amyloidosis
Interventions: DRUG: APG-2575+ Pd|DRUG: APG-2575 + DRd
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abuse Potential Assessment of Intranasally Administered EMBEDA Compared To Morphine Sulfate Controlled Release And Placebo
Status: COMPLETED
Conditions: Narcotic Abuse|Opioid-related Disorders|Analgesia|Chronic Pain
Interventions: DRUG: Placebo|DRUG: EMBEDA - morphine sulfate/ naltrexone hydrochloride|DRUG: morphine sulfate CR crushed.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PanDox: Targeted Doxorubicin in Pancreatic Tumours
Status: WITHDRAWN
Conditions: Pancreatic Ductal Adenocarcinoma|Pancreatic Cancer Stage IV|Pancreatic Cancer Non-resectable|Pancreatic Cancer Metastatic
Interventions: DEVICE: Focused Ultrasound|DRUG: Doxorubicin|DRUG: ThermoDox
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tiotropium vs. Inhaled Corticosteroids in Children With Nonatopic Asthma Pilot Study (TioNAAP)
Status: RECRUITING
Conditions: Asthma in Children
Interventions: DRUG: Tiotropium Bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fistulotomy as the Primary Cannulation Technique for All Patients Undergoing ERCP: A Randomized, Controlled Trial
Status: SUSPENDED
Conditions: Cholangiopancreatography, Endoscopic Retrograde|Biliary Tract Diseases
Interventions: PROCEDURE: Needle knife fistulotomy|PROCEDURE: Sphincterotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Randomized Trial of Remote Monitoring of Implantable Cardioverter Defibrillators Versus Quarterly Device Interrogations in Clinic
Status: COMPLETED
Conditions: Tachycardia, Ventricular|Ventricular Fibrillation
Interventions: OTHER: Methods for monitoring patients with ICD's
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Anlotinib Combined With Gemcitabine/Cisplatin in Advanced Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Recurrent Nasopharyngeal Carcinoma|Metastatic Nasopharyngeal Carcinoma
Interventions: DRUG: Anlotinib plus gemcitabine/cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apathy in Late Life Depression: New Biomarkers Using Actimetry and Magnetic Resonance Imaging
Status: COMPLETED
Conditions: Depression
Interventions: OTHER: Mattis Dementia Rating Scale|OTHER: Unified Parkinson 's Disease Rating Scale-III|OTHER: Mini Neuropsychiatric Investigation|OTHER: Montgomery and Asberg depression Rating Scale|OTHER: Clinical Global Impression|OTHER: Apathy diagnostic criteria|OTHER: walking speed test|OTHER: accelerometer presentation|OTHER: data acquisition from the accelerometer|OTHER: Apathy Evaluation Scale,|OTHER: fatigue Visual Analog Scale|OTHER: executive function|OTHER: MRI|OTHER: Apathy Motivation Index
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Omega-3 Fatty Acids for Hyperactivity Treatment in Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autism Spectrum Disorders|Hyperactivity
Interventions: DRUG: Omega-3 Fatty Acids|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adverse Metabolic Effects of Dietary Sugar
Status: COMPLETED
Conditions: Chronic Disease of Cardiovascular System|Type 2 Diabetes|Obesity
Interventions: OTHER: high fructose corn syrup|OTHER: aspartame|OTHER: Energy-balanced diet|OTHER: Ad libitum diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Noxipoint Therapy Versus Physical Therapy With TENS on Chronic Neck Pain
Status: COMPLETED
Conditions: Cervical Pain
Interventions: PROCEDURE: Noxipoint Therapy (NT)|PROCEDURE: Physical therapy(PT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Platelet-rich Plasma (PRP) vs Viscosupplementation for the Treatment of Early Knee Articular Degenerative Pathology
Status: COMPLETED
Conditions: Knee Chondropathy|Knee Early Osteoarthritis
Interventions: BIOLOGICAL: PRP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid Use on Pain, Mobility and Bleeding Following Total Hip and Total Knee Arthroplasty
Status: NOT_YET_RECRUITING
Conditions: Postoperative Bleeding
Interventions: DRUG: Tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tipifarnib in Treating Patients With Advanced Hematologic Cancer
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
Interventions: DRUG: tipifarnib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperthermic Intravesical Perfusion for Muscle-invasive Bladder Urothelial Carcinoma
Status: RECRUITING
Conditions: High-Risk, Non-Muscle Invasive Bladder Urothelial Carcinoma|Perfusion; Complications|Intraoperative Complications
Interventions: DEVICE: hyperthermic intravesical perfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Spleen-ARFI-assisted-Portal-Hypertension-Evaluation-Study (SAPHES)
Status: UNKNOWN
Conditions: Hypertension, Portal
Interventions: DIAGNOSTIC_TEST: ARFI-elastography and portal vein flow measurement|DIAGNOSTIC_TEST: HVPG-measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Needle-based Confocal Endomicroscopy Examination of Pancreatic Masse
Status: COMPLETED
Conditions: Pancreatic Neoplasms|CHRONIC PANCREATITIS
Interventions: DEVICE: needle based CLE|PROCEDURE: EUS-FNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Cardiovascular Events iN Diabetes Plus
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide Oral Tablet|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study To Assess Pharmacokinetics, Safety & Efficacy of Anidulafungin When Treating Children With Invasive Candidiasis
Status: COMPLETED
Conditions: Candidemia
Interventions: DRUG: Anidulafungin|DRUG: Fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label, Multi-center Trial of Zonisamide as Adjunctive Therapy in Patients With Uncontrolled Partial Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: zonisamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-operative RT and TMZ in Patients With Newly Diagnosed GBM Diagnosed Glioblastoma. A Phase I Study. (PARADIGMA)
Status: WITHDRAWN
Conditions: Glioblastoma Multiforme, Adult
Interventions: DRUG: Temozolomide|RADIATION: Pre-Operative Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Are Post-operative Antibiotics Indicated in Simple Appendicitis?
Status: UNKNOWN
Conditions: Appendicitis
Interventions: DRUG: metronidazole and cephalzolin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of BMS-823778 to Treat Uncontrolled High Blood Pressure in Overweight and Obese Patients
Status: TERMINATED
Conditions: Hypertension
Interventions: DRUG: BMS-823778|DRUG: BMS-823778|DRUG: BMS-823778|DRUG: Placebo matching with BMS-823778
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Patisiran (ALN-TTR02) in Transthyretin (TTR) Amyloidosis
Status: COMPLETED
Conditions: TTR-mediated Amyloidosis
Interventions: DRUG: Patisiran
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT