pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Better Together Physician Coaching to Mitigate Burnout Amongst Clinicians
Status: ACTIVE_NOT_RECRUITING
Conditions: Burnout, Professional|Self Compassion|Flourishing|Imposter Syndrome|Moral Injury|Loneliness
Interventions: BEHAVIORAL: Better Together Physician Coaching Program|BEHAVIORAL: No intervention - waitlist control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MRI-guided Holmium-166 Radioembolization
Status: ENROLLING_BY_INVITATION
Conditions: Primary Liver Cancer|Non-Resectable Hepatocellular Carcinoma
Interventions: PROCEDURE: MRI-guided radioembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Lepidium Meyenii Walp on Sexual Function in Postmenopausal Women
Status: UNKNOWN
Conditions: Sexual Dysfunction, Physiological
Interventions: BEHAVIORAL: The Female Sexual Function Index (FSFI)|BEHAVIORAL: The Female Intervention Efficacy Index (FIEI)|BEHAVIORAL: The Beck Depression Inventory II|DRUG: Lepidium Meyenii Walp|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Secukinumab in Patients With Newly-diagnosed Type 1 Diabetes Mellitus
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Secukinumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: EZH2 Inhibitor, Tazemetostat, and PD-1 Blockade for Treatment of Advanced Non-small Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Tazemetostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alveolar Ridge Preservation in Molar Extraction Sockets With an Open Healed Collagen Membrane: A Randomized Clinical Trial.
Status: RECRUITING
Conditions: Tooth Extraction
Interventions: PROCEDURE: membrane guided regeneration|PROCEDURE: collagen plug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aerobic Exercise Training & the Autonomic System In Patients After Myocardial Infarction or Stroke
Status: UNKNOWN
Conditions: HR Vaiability, Aerobic Physical Fitness,Blood Pressure, Blood Sugar Level, Blood HDL, LDL
Interventions: PROCEDURE: Aerobic exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acquisition of Responses to a Methamphetamine-associated Cue in Healthy Humans
Status: COMPLETED
Conditions: Substance Abuse
Interventions: DRUG: methamphetamine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Colchicine on Range of Motion After Manipulation Under Anesthesia for the Stiff Total Knee Replacement
Status: SUSPENDED
Conditions: Manipulation Under Anesthesia
Interventions: DRUG: Colchicine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Efficacy of Tropicamide Thin Films to Reduce Hypersalivation in Parkinson's Patients
Status: COMPLETED
Conditions: Sialorrhea (Excessive Drooling)
Interventions: DRUG: NH004 tropicamide|DRUG: NH004 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib and Iodine Therapy in Treating Patients With Radioactive Iodine-Sensitive Differentiated Thyroid Cancer
Status: TERMINATED
Conditions: Differentiated Thyroid Gland Carcinoma|Thyroid Gland Follicular Carcinoma|Thyroid Gland Papillary Carcinoma
Interventions: DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pertussis Vaccine in Healthy Pregnant Women
Status: COMPLETED
Conditions: Diphtheria|Pertussis|Tetanus
Interventions: DRUG: Placebo|BIOLOGICAL: Tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine adsorbed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intratissue Percutaneous Electrolysis vs Dry Needling in Myofascial Pain Syndrome of Shoulder Pain
Status: RECRUITING
Conditions: Shoulder Pain|Myofascial Pain Syndrome
Interventions: PROCEDURE: Intratissue Percutaneous Electrolysis|PROCEDURE: Dry Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selective Estrogen Modulation and Melatonin in Early COVID-19
Status: WITHDRAWN
Conditions: Covid19
Interventions: DRUG: Toremifene|DRUG: Melatonin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety of Xospata in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) With FMS-Like Tyrosine Kinase 3 (FLT3) Mutation
Status: RECRUITING
Conditions: Acute Myeloid Leukemia With FMS-like Tyrosine Kinase (FLT3) Mutation
Interventions: DRUG: Gilteritinib Exposure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Formoterol Via pMDI HFA-134a Propellant or DPI in Partially Reversible Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Formoterol|DRUG: Formoterol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluating the Pharmacokinetics and Mode of Action of EndoTAG®-1 in Tumor Patients With Hepatic Metastases
Status: COMPLETED
Conditions: Liver Cancer|Neoplasm Metastasis
Interventions: DRUG: EndoTAG®-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tocilizumab in the Treatment of Refractory Polymyositis and Dermatomyositis
Status: COMPLETED
Conditions: Dermatomyositis|Polymyositis
Interventions: DRUG: tocilizumab|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Human Lab Study of Lacosamide in Alcohol Use Disorder (AUD)
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: DRUG: Placebo|DRUG: Lacosamide 100 mg|DRUG: Lacosamide 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Using Flash Glucose Measurements for a New Once-weekly Insulin (Insulin Icodec) in People With Type 2 Diabetes Who Have Not Used Insulin Before (ONWARDS 9)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin Icodec
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ibrutinib in Combination With Rituximab, in Japanese Participants With Waldenstrom's Macroglobulinemia (WM)
Status: COMPLETED
Conditions: Waldenstrom Macroglobulinemia
Interventions: DRUG: Ibrutinib|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Survivorship Care for Women Living With Ovarian Cancer: (POSTCARE-O)
Status: RECRUITING
Conditions: Ovarian Neoplasm|Depressive Symptoms|Quality of Life
Interventions: BEHAVIORAL: POSTCare Survivorship transition process
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomized Controlled Trial to Address Unintended Pregnancy Rates in Low Resource Settings
Status: COMPLETED
Conditions: Contraceptive Usage|Unintended Pregnancy
Interventions: BEHAVIORAL: Community Score Card|BEHAVIORAL: Citizen Report Card
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Primary Prevention of Patients With Hepatocellular Carcinoma and Concomitant Esophageal Varices
Status: RECRUITING
Conditions: Bleeding Esophageal Varices|Hepatocellular Carcinoma
Interventions: DRUG: Propranolol|PROCEDURE: Esophageal variceal ligation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug-Interaction Study of Necitumumab (IMC-11F8) in Combination With Gemcitabine-Cisplatin
Status: COMPLETED
Conditions: Malignant Solid Tumor
Interventions: BIOLOGICAL: Necitumumab|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Donor Stem Cells and Alemtuzumab to Prevent Organ Rejection in Kidney Transplant Patients
Status: COMPLETED
Conditions: Kidney Transplantation|Kidney Disease|Kidney Failure
Interventions: DRUG: Alemtuzumab|DRUG: Mycophenolate mofetil|DRUG: Sirolimus|DRUG: Tacrolimus|PROCEDURE: Donor bone marrow stem cell infusion|PROCEDURE: Kidney transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Does it Make Sense to Give Postoperative Antibiotics to Patients With an Uncomplicated Acute Cholecystitis
Status: COMPLETED
Conditions: Uncomplicated Acute Cholecystitis
Interventions: DRUG: Whether or not giving postoperatively antibiotics to patients with an uncomplicated acute cholecystitis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intravenous (IV) Methylnaltrexone (MNTX) in the Prevention of Post-Operative Ileus
Status: COMPLETED
Conditions: Postoperative Ileus
Interventions: DRUG: IV Methylnaltrexone (MNTX)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Tolvaptan Phase 3 Efficacy and Safety Study in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Status: COMPLETED
Conditions: Polycystic Kidney Disease, Autosomal Dominant
Interventions: DRUG: Tolvaptan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Treatment Related Toxicity Study of a New Regimen for Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma|Hodgkin's Disease
Interventions: DRUG: gemcitabine, vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: T-DM1 vs Paclitaxel/Trastuzumab for Breast (ATEMPT Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab|DRUG: Paclitaxel|DRUG: Trastuzumab emtansine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient Doctor Lies
Status: COMPLETED
Conditions: Patient Lying|Privacy Statements|Risk Statements|Benefit Statements|Patient Lie Detection
Interventions: BEHAVIORAL: Benefit statement|BEHAVIORAL: Risk Statement|BEHAVIORAL: Privacy Statement|BEHAVIORAL: Benefit + Privacy|BEHAVIORAL: Risk + Privacy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Intubation Success Rates of 3 Different Laryngoscope Blade Types in Morbidly Obese Patients
Status: COMPLETED
Conditions: Intubation;Difficult|Morbid Obesity
Interventions: DEVICE: endotracheal intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Bounce Back Program
Status: UNKNOWN
Conditions: Depression
Interventions: BEHAVIORAL: Telephone-supported self-help and GP treatment as usual|BEHAVIORAL: Unsupported self-help and GP treatment as usual|OTHER: General practitioner treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Levonorgestrel-releasing Intrauterine System for the Treatment of Symptomatic Adenomyosis
Status: COMPLETED
Conditions: Adenomyosis
Interventions: PROCEDURE: Placement of levonorgestrel-releasing intrauterine system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibrutinib in Patients With Refractory/Relapsed Non-GCB Diffuse Large B-cell Lymphoma Non-candidates to Autologous Stem Cell Transplantation
Status: UNKNOWN
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Ibrutinib|DRUG: Rituximab|DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bupivacaine vs Placebo for Unilateral Mastectomy Surgical Site Post-operative Pain Control
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Bupivacaine|BEHAVIORAL: patient-reported pain scores|OTHER: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of ZD4054 in Prior Chemotherapy Treated Patients With Metastatic Hormone-resistant Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer|Metastasis
Interventions: DRUG: ZD4054
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Suprachoroidally Administered CLS-AX in the Treatment of Neovascular Age-Related Macular Degeneration
Status: ACTIVE_NOT_RECRUITING
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: CLS-AX|DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Thorough QTc Evaluation of the Effect of Semaglutide on Cardiac Repolarisation in Healthy Subjects
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: semaglutide|DRUG: placebo|DRUG: moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Muscle-Related Side Effects of Statins: Functional Impact, Mechanisms, and Potential Relief With Vitamin D Supplementation
Status: COMPLETED
Conditions: HMG COA Reductase Inhibitor Adverse Reaction
Interventions: DRUG: Vitamin D|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Study Comparing Risankizumab to Placebo in Participants With Active Psoriatic Arthritis Including Those Who Have a History of Inadequate Response or Intolerance to Biologic Therapy(Ies)
Status: ACTIVE_NOT_RECRUITING
Conditions: Psoriatic Arthritis (PsA)
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: Risankizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Dependent Effects of Erythritol on Endothelial Function in Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Erythritol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Vibroacoustic Therapy on Acute Stress in University Students
Status: UNKNOWN
Conditions: Stress, Psychologic
Interventions: OTHER: Vibroacoustic therapy|OTHER: Only music (no vibrations)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Human-centered Design and Communities of Practice to Improve Delivery of Home-based Tuberculosis Contact Investigation in Uganda
Status: COMPLETED
Conditions: Tuberculosis|Tuberculosis, Pulmonary
Interventions: BEHAVIORAL: User-Centered Implementation Strategy|BEHAVIORAL: Standard Implementation Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Study of LBH589, A Deacetylase Inhibitor in Patients With Recurrent or Refractory Hodgkin or Non-Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma
Interventions: DRUG: LBH589
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Global, Multicenter Study to Assess Maternal, Fetal and Infant Outcomes of Exposure to Palynziq® (Pegvaliase) During Pregnancy and Breastfeeding
Status: RECRUITING
Conditions: Phenylketonuria, Maternal
Interventions: DRUG: Pegvaliase
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Staphylococcal Toxins in Atopic Dermatitis and Eczema Herpeticum
Status: UNKNOWN
Conditions: Atopic Dermatitis|Staphylococcus Aureus|Bacterial Toxins|Immune Response|Cytokines|T Cells Subsets
Interventions: OTHER: Skin biopsies and blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Research Study to See How Well CagriSema Helps People in China With Excess Body Weight Lose Weight
Status: RECRUITING
Conditions: Obesity or Overweight
Interventions: DRUG: Cagrilintide|DRUG: Semaglutide|DRUG: Placebo Semaglutide|DRUG: Placebo Cagrilintide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fundamental and Applied Concussion Recovery Modality Research and Development: Applications for the Enhanced Recovery
Status: WITHDRAWN
Conditions: Traumatic Brain Injury|Post-Concussion Syndrome|Concussion, Brain
Interventions: OTHER: Float-REST|OTHER: Photobiomodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Adjunctive Use of Intra-Arterial TNK and Albumin Following Thrombectomy
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Intra-Arterial TNK and Albumin|DRUG: Intra-Arterial TNK|DRUG: Intra-Arterial Albumin|OTHER: sham
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Concord Grape Juice on Endothelial Function
Status: COMPLETED
Conditions: Obesity|Overweight
Interventions: OTHER: Active Concord Grape Juice 12 oz per day|OTHER: Placebo Grape Juice 12 oz per day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Vascular Biomarkers Predictive of the Progression From Gestational Hypertension to Preeclampsia in Pregnant Women
Status: RECRUITING
Conditions: Gestational Hypertension|Pre-eclampsia
Interventions: OTHER: Determination of the UEMP levels|PROCEDURE: Aortic central pressure and the carotid-femoral pulse wave velocity|OTHER: Vascular biomarker assay|PROCEDURE: Measurement of the uterine artery diameter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pharmacological and Non-pharmacological Treatment Effects on Children With Different Predicted Myopia Progression Rate
Status: RECRUITING
Conditions: Myopia
Interventions: DRUG: Atropine 0.05%|DEVICE: DIMS lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Normative Values Laser Nociceptive Evoked Potentials Depending on the Age
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: laser stimulations on lower limbs|DEVICE: laser stimulations cervical|DEVICE: 20 laser stimulations for each site on the upper limbs|DEVICE: laser stimulations on face and neck
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Optical Biopsy for Distal Margin in Low Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: DEVICE: Probe-based confocal laser endomicroscopy optical biopsy|DEVICE: Intra-operative frozen section
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Patient Satisfaction With Timolol in Subjects With Open-Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma, Open Angle|Ocular Hypertension
Interventions: DRUG: Timolol Maleate in Sorbate|DRUG: Timolol hemihydrate|DRUG: Timolol maleate gel forming solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GUARDIAN (NCT04884802) Sub-study, Phenylephrine v. Norepinephrine
Status: ENROLLING_BY_INVITATION
Conditions: Blood Pressure
Interventions: DRUG: Phenylephrine|DRUG: Norepinephrine|DRUG: Phenylephrine|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of 6 ml/kg vs 10 ml/kg Tidal Volume on Diaphragm Dysfunction in Critically Mechanically Ventilated Patient
Status: UNKNOWN
Conditions: Mechanical Ventilation Complication
Interventions: OTHER: Tidal volume 6 ml/kg|OTHER: Tidal volume 10 ml/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Buprenorphine vs. Opioid Dose Escalation Among Patients With Chronic Pain
Status: TERMINATED
Conditions: Pain
Interventions: DRUG: buprenorphine/naloxone|DRUG: opioid dose escalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cortical Modulation of Acute Post-thoracotomy Pain With Transcranial Direct Current Stimulation
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DEVICE: Transcranial direct current stimulation|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I , MTD, Pharmacokinetic, Safety/Tolerability, Efficacy of IOP Injection for MRI in Healthy Subjects
Status: COMPLETED
Conditions: Magnetic Resonance Imaging
Interventions: DRUG: IOP Injection|DRUG: 0.9% normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Bevacizumab in Combination With Capecitabine and Cisplatin as First-line Therapy in Patients With Advanced Gastric Cancer
Status: COMPLETED
Conditions: Adenocarcinoma
Interventions: DRUG: Bevacizumab|DRUG: Capecitabine|DRUG: Cisplatin|DRUG: Placebo|DRUG: 5-fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Double-blinded Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide and Insulin Degludec Both in Combination With Metformin in Japanese Subjects With Type 2 Diabetes Mellitus Inadequately Controlled With Basal or Pre-mix/Combination Insulin Therapy and Oral Anti-diabetic Drugs
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin degludec/liraglutide|DRUG: Insulin degludec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study to Evaluate KADIAN and Avinza in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: KADIAN (morphine sulfate sustained-release) capsules|DRUG: Avinza (morphine sulfate sustained-release) capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Detection and Cytotoxic T Lymphocyte Therapy of Post-Transplant Lymphoproliferative Disorder After Liver Transplant
Status: COMPLETED
Conditions: Liver Disease|Lymphoproliferative Disorders
Interventions: BIOLOGICAL: EBV-specific autologous CTL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Rabbit Antithymocyte Globulin (Thymoglobuline) With Ciclosporin for Patients With Acquired Aplastic Anaemia
Status: COMPLETED
Conditions: Aplastic Anemia
Interventions: DRUG: rabbit antithymocyte globulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of a Physio-neuro Platform (SynPhNe) for Home-based Retraining of Hand Function in Stroke Survivors
Status: NOT_YET_RECRUITING
Conditions: Stroke|Hemiparesis
Interventions: DEVICE: SynPhNe platform|OTHER: Conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial (RCT) Umbilical Hernia Repair (UHR) Absorbable vs Non-absorbable Synthetic Mesh
Status: NOT_YET_RECRUITING
Conditions: Umbilical Hernia
Interventions: DEVICE: Enform Mesh|DEVICE: Marlex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: QT Interval Prolongation Study of Eribulin Mesylate (E7389) in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumor
Interventions: DRUG: Eribulin Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TRV130 for the Treatment of Pain After Bunionectomy
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: TRV130|DRUG: Morphine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Efficacy and Safety of TQA3810 Tablets in Combination/Non Combination With Nucleoside (Acid) Analogues in Patients With Primary/Treated Chronic Hepatitis B
Status: RECRUITING
Conditions: Chronic Hepatitis B
Interventions: DRUG: TQA3810 tablets+NUC|DRUG: Placebo+NUC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Psoriasis Plaque Test Trial With LEO 90100 Compared to Betesil® in Patients With Psoriasis Vulgaris
Status: COMPLETED
Conditions: Skin and Connective Tissue Diseases
Interventions: DRUG: LEO 90100 Aerosol foam|DRUG: Betesil® 2.25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin B12 Biomarker Responses to Supplementation
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Folic Acid|DIETARY_SUPPLEMENT: 2 µg Vitamin B12|DIETARY_SUPPLEMENT: 10 µg Vitamin B12|DIETARY_SUPPLEMENT: 50 µg Vitamin B12
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TEFA Family Prevention: Glutenfree Diet to Preserve Beta-cell Function
Status: UNKNOWN
Conditions: Prediabetes|Type 1 Diabetes
Interventions: DIETARY_SUPPLEMENT: Gluten free diet|DIETARY_SUPPLEMENT: Omega 3 fatty acid|DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: Probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase IV, Prospective, Observational, Open Label, Single Centre Cohort Trial to be Conducted in Norway During One Year to Assess the Cumulative Pregnancy Rate in a New Series of In-vitro Fertilization (IVF) Treatment Cycles Following Three or More Previous IVF Treatment Cycles Without Live Birth
Status: COMPLETED
Conditions: Infertility
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Subcutaneously Administered CAMPATH in CD52 Expressing Hematologic Malignancies
Status: TERMINATED
Conditions: Hematologic Malignancies
Interventions: DRUG: CAMPATH (alemtuzumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Multiple Dosing Regimens of BPS804 in Post Menopausal Women With Low Bone Mineral Density
Status: COMPLETED
Conditions: Osteopenia|Osteoporosis
Interventions: DRUG: BPS804 20mg/Kg|DRUG: Placebo to 20mg/Kg BPS804
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Carbohydrate Co-ingestion on the Post-prandial Anabolic Response of Protein in Young and Elderly Men
Status: COMPLETED
Conditions: Sarcopenia
Interventions: DIETARY_SUPPLEMENT: Protein|DIETARY_SUPPLEMENT: Protein + carbohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of CL-197 Capsules in Healthy Participants
Status: COMPLETED
Conditions: HIV-1
Interventions: DRUG: 1 mg CL-197 capsules|DRUG: 10 mg CL-197 capsules or CL-197 placebo|DRUG: 30 mg CL-197 capsules or CL-197 placebo|DRUG: 60 mg CL-197 capsules or CL-197 placebo|DRUG: 100 mg CL-197 capsules or CL-197 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endostar Combined With mFOLFOX6 for First-line Treatment of Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Endostar|DRUG: Oxaliplatin|DRUG: Folinic acid|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of an Acute Bout of Exercise on Pain Sensitivity and Clinical Pain in Adults With Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low-back Pain
Interventions: OTHER: Single bout of exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and PK of LBP-EC01 in Patients With Lower Urinary Tract Colonization Caused by E. Coli
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: DRUG: LBP-EC01|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Modified SALT Score for Alopecia Areata
Status: UNKNOWN
Conditions: Alopecia Areata
Interventions: DRUG: Triamcinolone Acetonide|OTHER: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Tumor Necrosis Factor-alpha Levels and Cardiac Functions in Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Systolic Dysfunction|Diastolic Dysfunction
Interventions: DIAGNOSTIC_TEST: transthoracic echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Belantamab Mafodotin and Lenalidomide for the Treatment of Multiple Myeloma in Patients With Minimal Residual Disease Positive After Stem Cell Transplant
Status: RECRUITING
Conditions: Plasma Cell Myeloma
Interventions: BIOLOGICAL: Belantamab Mafodotin|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess Safety, Tolerability and PK of NEX-20A, a Subcutaneous Prolonged-release Injection to Healthy Subjects
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: NEX-20A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EEG Parameters Between Remimazolam- and Propofol-based Anesthesia
Status: COMPLETED
Conditions: Cholecystitis, Acute|Gallbladder Neoplasms|Acalculous Cholecystitis
Interventions: DRUG: propofol group|DRUG: remimazolam group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of Osteopathic Protocol on Rachialgia
Status: COMPLETED
Conditions: Spine Injuries and Disorders
Interventions: OTHER: Osteopathic Protocol in 2 Sessions (PO2S)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AC6 Gene Transfer in Patients With Reduced Left Ventricular Ejection Fraction Heart Failure
Status: WITHDRAWN
Conditions: Heart Failure
Interventions: DRUG: Ad5.hAC6|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HSCT for High Risk Inherited Inborn Errors
Status: COMPLETED
Conditions: Adrenoleukodystrophy|Metachromatic Leukodystrophy|Globoid Cell Leukodystrophy|Tay Sachs Disease|Sandhoffs Disease|Wolman Disease|I-Cell Disease|Sanfilippo Syndrome|GM1 Gangliosidosis
Interventions: DRUG: Clofarabine|PROCEDURE: Total body Irradiation|DRUG: Melphalan|BIOLOGICAL: Hematopoietic Stem Cell Transplantation|DRUG: Alemtuzumab|DRUG: mycophenylate mofetil|DEVICE: Cyclosporine A|DRUG: Hydroxyurea
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Calory Restriction and Biofeedback on Endocrine and Mental Health
Status: COMPLETED
Conditions: Neuroendocrinology|Mental Stress|Psychological|Obesity
Interventions: BEHAVIORAL: Calory Restriction (F.X. Mayr & VLCD)|BEHAVIORAL: Biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study With Adalimumab Biosimilar
Status: COMPLETED
Conditions: Pharmacokinetics|Safety Issues
Interventions: BIOLOGICAL: Humira® (adalimumab) AC Pen [Reference Product]|BIOLOGICAL: Adalimumab Richmond [Test Product]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate Mesenchymal Stem Cell Product StromaForte's Effect on Cardiovascular Events
Status: RECRUITING
Conditions: Cardiovascular Diseases
Interventions: BIOLOGICAL: Human Allogeneic Bone-Marrow-Derived Mesenchymal Stromal Cell Product (StromaForte)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Itraconazole on the Pharmacokinetics of Debio 1450 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Debio 1450|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: E4/DRSP Single and Multiple Dose PK and Early QT Study
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: 15 mg E4/3 mg DRSP|DRUG: 30 mg E4/6 mg DRSP|DRUG: 60 mg E4/12 mg DRSP|DRUG: Visually matching placebo|DRUG: 75 mg E4/15 mg DRSP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Early Fluid Resuscitation With Balanced HES 130/0.4 [6%] in Severe Burn Injury
Status: UNKNOWN
Conditions: Burns
Interventions: DRUG: Fluid resuscitation|DRUG: HES 130/0.4 (6%), Voluven balanced vs. Lactated Ringer's solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II , Placebo-controlled Study to Assess Efficacy of 28 Day Oral AZD9668 in Patients With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: AZD9668|DRUG: AZD9668 Placebo equivalent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab.
Status: ACTIVE_NOT_RECRUITING
Conditions: Eosinophilic Granulomatous Vasculitis
Interventions: BIOLOGICAL: Benralizumab|BIOLOGICAL: Mepolizumab|BIOLOGICAL: Placebo to Mepolizumab|BIOLOGICAL: Placebo to Benralizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Visualization Engineering Platform for TCM Pulse Diagnosis - Pulse Diagnosis Based on Federated Learning to Diagnose Slippery and Choppy and Other Pulses Waveform Image Features to Assist in the Study of TCM Pathological Logic Analysis
Status: RECRUITING
Conditions: Slippery Pulse|Choppy Pulse
Interventions: DIAGNOSTIC_TEST: Recurrent Neural Network
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Performance Assessment Of The PMD-200 In Subjects With Degenerative Lumbar Spine Disease Who Requires Surgical Procedure
Status: TERMINATED
Conditions: Degenerative Diseases, Nervous System
Interventions: DEVICE: PMD-200|DIAGNOSTIC_TEST: SLR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacokinetic, Safety and Efficacy of Intermittent Application of Caspofungin for Antifungal Prophylaxis
Status: COMPLETED
Conditions: Fungal Infection
Interventions: DRUG: caspofungin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of S-268019 for the Prevention of COVID-19
Status: COMPLETED
Conditions: SARS-CoV-2
Interventions: DRUG: S-268019-b|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Cervical Mobilization on Balance and Plantar Pressure Distribution in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Muscle Spasticity|Pressure Area|Cervical Region Disorder Nos
Interventions: OTHER: Traditional Rehabilitation for multiple sclerosis|OTHER: Cervical mobilization for multiple sclerosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of SUN 131 TDS as Compared to Placebo TDS in Adult Patients With a Chalazion
Status: COMPLETED
Conditions: Chalazion
Interventions: DRUG: SUN-131 1.5% TDS|DRUG: Placebo TDS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ginger as an Adjunctive Prophylaxis for Chemotherapy-induced Nausea and Vomiting
Status: COMPLETED
Conditions: Chemotherapy-induced Nausea and Vomiting
Interventions: DRUG: Ginger|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Risk Characterization of Non-culprit Vessels in Patients Undergoing Primary PCI for ST-elevation MI in Multivessel Disease
Status: NOT_YET_RECRUITING
Conditions: ST Elevation Myocardial Infarction
Interventions: DIAGNOSTIC_TEST: CT Coronary Angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bevacizumab With or Without Anti-Endoglin Monoclonal Antibody TRC105 in Treating Patients With Recurrent Glioblastoma Multiforme
Status: COMPLETED
Conditions: Adult Anaplastic Astrocytoma|Adult Anaplastic Oligodendroglioma|Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Adult Mixed Glioma|Recurrent Adult Brain Neoplasm
Interventions: BIOLOGICAL: Anti-Endoglin Chimeric Monoclonal Antibody TRC105|BIOLOGICAL: Bevacizumab|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First-In-Human Study of Orally Administered JNJ-64417184 to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses, and the Antiviral Activity of Multiple Doses in a Respiratory Syncytial Virus (RSV) Challenge Study in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-64417184|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TMC125HIV1083 - Swallowability of Uncoated 200 mg Etravirine Tablets in HIV-1 Infected Patients
Status: COMPLETED
Conditions: HIV-Infections
Interventions: DRUG: etravirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Adjunct Minocyline in Treatment-resistant Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Minocycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intervention With n3 LC-PUFA-supplemented Yogurt
Status: COMPLETED
Conditions: Moderate Hypertriacylglycerolemic Subjects
Interventions: DIETARY_SUPPLEMENT: n3 long chain polyunsaturated fatty acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: T Cell Mediated Adaptive Therapy for Her2-positive Neoplasms of Digestive System
Status: UNKNOWN
Conditions: Esophageal Cancer|Gastric Cancer|Pancreatic Cancer|Liver Cancer|Gallbladder Cancer|Bowel Cancer
Interventions: DRUG: Recombinant Human Interleukin-2|DRUG: HER2Bi-Armed T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studying Gene Expression in Samples From Younger Patients With Neuroblastoma
Status: COMPLETED
Conditions: Neoplastic Syndrome|Neuroblastoma
Interventions: GENETIC: gene expression analysis|GENETIC: protein expression analysis|OTHER: enzyme-linked immunosorbent assay|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|OTHER: medical chart review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prevention Program to Reduce Injury Disparities Among Latino Day Laborers
Status: COMPLETED
Conditions: Work-related Injury
Interventions: BEHAVIORAL: Motivational Interview (MI)|BEHAVIORAL: Participatory Group Activity|BEHAVIORAL: Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Toripalimab Combined With Bevacizumab, Nab-paclitaxel and Carboplatin for Untreated Metastatic Pulmonary Sarcomatoid Carcinoma
Status: UNKNOWN
Conditions: Pulmonary Sarcomatoid Carcinoma|Non-small Cell Lung Cancer|Lung Diseases|Thoracic Neoplasms
Interventions: DRUG: Toripalimab|DRUG: Bevacizumab|DRUG: Nab-paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of CPP-ACP Prophylactic Effect on Enamel Surface During Orthodontic Treatment
Status: UNKNOWN
Conditions: White Spot Lesion|Enamel Hypomineralization
Interventions: DRUG: Casein Phosphopeptide-Amorphous Calcium Phosphate Dental Paste
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION