pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effectiveness of HIV/Sexually Transmitted Infection Training for Physicians in China
Status: COMPLETED
Conditions: HIV Infections|Gonorrhea|Chlamydia
Interventions: BEHAVIORAL: Physician Ai Shi Zi training|DRUG: Standard care|BEHAVIORAL: Patient risk-reduction counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating the Effect of Fluticasone Furoate/ Vilanterol (FF/VI) Inhalation Powder Compared With Vilanterol (VI) Inhalation Powder on Bone Mineral Density (BMD) in Subjects With Chronic Obstructive Pulmonary Disease (COPD).
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Fluticasone Furoate/Vilanterol|DRUG: Vilanterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assess the Penumbra System in the Treatment of Acute Stroke
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: intravenous (IV) recombinant human tissue plasminogen activator (rtPA)|DEVICE: Penumbra System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influencing Factors and Prediction Model of Poor Prognosis of Spontaneous Intraparenchymal Hemorrhage
Status: RECRUITING
Conditions: Spontaneous Intracranial Hemorrhage|Spontaneous Intraparenchymal Cerebral Hemorrhage|Spontaneous Cerebellar Haemorrhage
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Personalized Colonoscopy Preparation for Patients With Risk Factors for Inadequate Preparation
Status: UNKNOWN
Conditions: Inadequate Preparation for Colonoscopy; Personalized Colonoscopy Preparation
Interventions: DRUG: Sodium Picosulfate / Magnesium Oxide / Citric Acid in two split doses + one dose of polyethylene glycol + two Bisacodyl tablets day before the procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of the AIRVO Warm Humidifier as an Add on to Oxygen Therapy
Status: UNKNOWN
Conditions: COPD|Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: Airvo Humidifier
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study of Heart Failure With Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-HF)
Status: SUSPENDED
Conditions: Heart Failure
Interventions: BIOLOGICAL: Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#)|DRUG: conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expressive Arts-based Intervention for Adults With Age-related Visual Impairment
Status: RECRUITING
Conditions: Age-Related Macular Degeneration
Interventions: BEHAVIORAL: Expressive Arts-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MirvasO Soolantra Association In the Treatment of Moderate to Severe rosaCea.
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: Brimonidine 0.33% gel (Br)|OTHER: CD07805/47 (Br) placebo gel|DRUG: Ivermectin 1% cream (IVM)|OTHER: CD5024 (IVM) placebo cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DHA (Docosahexaenoic Acid), an Omega 3 Fatty Acid, in Slowing the Progression of Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: DHA (Docosahexaenoic Acid)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of General Anesthesia and Combined Anesthesia in Controlled Hypotension During Arthroscopic Shoulder Surgery
Status: NOT_YET_RECRUITING
Conditions: Shoulder Injuries|Shoulder Osteoarthritis
Interventions: PROCEDURE: Brachial plexus block|PROCEDURE: General anesthesia|PROCEDURE: Suprascapular nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Pioglitazone Treatment on Sympathetic Nervous System Function in Metabolic Syndrome Obesity
Status: UNKNOWN
Conditions: Metabolic Syndrome
Interventions: DRUG: Pioglitazone|DRUG: sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of eHealth in Communication With Patients About Prenatal Diagnosis
Status: COMPLETED
Conditions: Downs Syndrome|Health Knowledge, Attitudes, Practice
Interventions: BEHAVIORAL: Access to the website www.graviditetsportalen.dk|BEHAVIORAL: Access to the website www.ouh.dk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Balanced Crystalloid and Colloid Infusion on Haemostasis in Healthy Male Volunteers
Status: UNKNOWN
Conditions: Perioperative Hemorrhage|Dilutional Coagulopathy
Interventions: DIAGNOSTIC_TEST: Standard laboratory coagulation tests and rotational thromboelastometry measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study to Examine the Efficacy and Safety of REGN5069 in Patients With Pain Due to Osteoarthritis of the Knee
Status: TERMINATED
Conditions: Osteoarthritis of the Knee|Pain
Interventions: DRUG: REGN5069|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SMall Annuli Randomized To Evolut™ or SAPIEN™ Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Symptomatic Aortic Stenosis|Aortic Valve Stenosis|Aortic Valve Replacement
Interventions: DEVICE: Medtronic Evolut PRO, Evolut PRO+ or Evolut FX (where commercially available) TAV Systems|DEVICE: Edwards SAPIEN 3 or SAPIEN 3 Ultra THV Systems
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Rising Dose Study of BI 655066 in Patients With Moderate and Severe Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: BI 655066 (very high i.v. dose)|DRUG: Placebo, i.v.|DRUG: BI 655066 (high s.c. dose)|DRUG: BI 655066 (low i.v. dose)|DRUG: BI 655066 (high medium i.v. dose)|DRUG: BI 655066 (very low i.v. dose)|DRUG: BI 655066 (low s.c. dose)|DRUG: BI 655066 (high i.v. dose)|DRUG: Placebo, s.c.|DRUG: BI 655066 (low medium i.v. dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Multi-Center Study of Different Doses Domperidone in Feeding Intolerance
Status: COMPLETED
Conditions: Feeding Intolerance|Premature Birth|Domperidone Overdose|Gastric Retention
Interventions: DRUG: Low dose|DRUG: normal dose|DRUG: over dose|DRUG: Glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Timing of Antihypertensive Medication on Diurnal Fluctuations in Blood Pressure Using a Wearable Sensor With Continuous Monitoring
Status: WITHDRAWN
Conditions: Hypertension
Interventions: PROCEDURE: Timing of medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study Comparing MB02 And EU Avastin® In Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers|Male|Japanese
Interventions: DRUG: MB02 (Bevacizumab Biosimilar)|DRUG: EU approved Avastin®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Cost-effectiveness of Different Antiretroviral Treatment in Patients HIV Naive
Status: UNKNOWN
Conditions: Patient Compliance|Antiretroviral Therapy Intolerance
Interventions: DRUG: elvitegravir/cobicistat/emtricitabine/tenofovir|DRUG: Darunavir|DRUG: abacavir/lamivudine|DRUG: Ritonavir|DRUG: Lamivudine|DRUG: rilpivirine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protein Supplementation and Mixed Power Training on Muscle Function and Functional Capacities in Elderly Men
Status: COMPLETED
Conditions: Dynapenia|Aging|Physical Impairment
Interventions: OTHER: Exercise + Placebo group|OTHER: Exercise + Protein group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Chemotherapy With or Without Radiation Therapy or Observation in Treating Young Patients With Advanced Retinoblastoma Who Have Undergone Surgery to Remove the Eye
Status: UNKNOWN
Conditions: Retinoblastoma
Interventions: DRUG: carboplatin|DRUG: cytarabine|DRUG: etoposide|DRUG: vincristine sulfate|OTHER: clinical observation|PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Level Laser Therapy for Treatment of Tinnitus in Red Sea Scuba Divers
Status: COMPLETED
Conditions: Tinnitus
Interventions: DEVICE: Low level laser therapy|OTHER: Sham device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Resilience and Loneliness in Youth (18 - 25 Years Old) During the COVID-19 Pandemic Lock-down Measures.
Status: COMPLETED
Conditions: Resilience, Psychological|Loneliness|Youth|Surveys and Questionnaires
Interventions: OTHER: Survey and Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Stereotactic Radiosurgery and Metformin in Patients With Borderline-Resectable or Locally-Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Acinar Cell Adenocarcinoma of the Pancreas|Duct Cell Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage I-III Pancreatic Cancer
Interventions: DRUG: metformin hydrochloride|RADIATION: stereotactic radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Docetaxel, Cisplatin, Fluorouracil (5-FU) for Unresectable Advanced Esophageal Squamous Cell Carcinoma (ESCC)
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: DRUG: DCF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Trastuzumab on Disease Free Survival in Early Stage HER2-Negative Breast Cancer Patients With ERBB2 Expressing Disseminated Tumor Cells
Status: TERMINATED
Conditions: Breast Neoplasms
Interventions: DRUG: Doxorubicin|BIOLOGICAL: Trastuzumab|DRUG: Cyclophosphamide|DRUG: Paclitaxel|DRUG: Epirubicin|DRUG: Docetaxel|DRUG: Carboplatin|DRUG: Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noise-Induced Hearing Loss-Acute Exposure Treatment (UA)
Status: TERMINATED
Conditions: Hearing Loss, Noise-Induced
Interventions: DRUG: Zonisamide 100Mg Cap|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pembrolizumab With Nab-Paclitaxel in Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Nab-Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Transarterial Chemoembolization (TACE) + Lenvatinib + Programmed Cell Death Protein 1 (PD-1) Antibody of Advanced Unresectable Hepatocellular Carcinoma
Status: ENROLLING_BY_INVITATION
Conditions: Hepatocellular Carcinoma Non-resectable|Transarterial Chemoembolization|Tyrosine Kinase Inhibitor|Immune Checkpoint Blockade
Interventions: DRUG: lenvatinib + sindilimab/carrelizumab|PROCEDURE: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Ischaemic Conditioning on Blood Pressure Control in Chronic Kidney Disease Patients
Status: UNKNOWN
Conditions: Chronic Kidney Diseases|Hypertension|Cardiovascular Diseases
Interventions: DEVICE: Active autoRIC® (CRIC Treatment)|DEVICE: Sham Control autoRIC® (Sham Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Identification and Characterization of Ovarian Cancer and Endometrial Cancer Specific Biomarkers in Vaginal Fluids
Status: WITHDRAWN
Conditions: Cancer of Ovary
Interventions: PROCEDURE: fluid sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: MENCORE-2: Audio Recordings to Improve Decision-making in Advanced Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer|Metastatic Prostate Cancer|Metastatic Castration-resistant Prostate Cancer
Interventions: BEHAVIORAL: Consultation audio recording app
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: LCMD for Type 2 Diabetes Remission: Evaluation of Effectiveness and Exploration of Individual Differences
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes Mellitus in Obese|Type 2 Diabetes
Interventions: COMBINATION_PRODUCT: Low-Calorie Medicine Diet|COMBINATION_PRODUCT: Low-Calorie Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of 5-FUci Versus CPT-11 Plus CDDP Versus S-1 Alone in Advanced Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: continuous infusion of 5-fluorouracil|DRUG: combination of irinotecan and cisplatin|DRUG: oral administration of S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Impact of Body Position on Diaphragmatic Excursion in Obese Patients to Improve Proactice in Respiratory Kinesitherapy
Status: RECRUITING
Conditions: Obesity
Interventions: OTHER: Measurement of the diaphragmatic excursion according to the position of the body by ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Positioning Imatinib for Pulmonary Arterial Hypertension
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Imatinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oblique Subcostal Tap Block Efficacy in Laparoscopic Cholecystectomy
Status: UNKNOWN
Conditions: Pain
Interventions: DRUG: Placebo|DRUG: Bupivacaine|DRUG: Pethidine|DRUG: Pethidine Local Infiltration (L.I)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protective Effect of Indocyanine Green Fluorescence Imaging Technology on Parathyroid Glands During Total Thyroidectomy
Status: RECRUITING
Conditions: Total Thyroidectomy|Parathyroid Function Low Adverse Event|Parathyroid Glands--Diseases|Indocyanine Green
Interventions: DEVICE: Indocyanine Green|DEVICE: No indocyanine green
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Manipulation of the Intratesticular Hormonal Milieu With Exogenous Testosterone (HOP 5) Testicular Aspiration Addendum
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Acyline|DRUG: Testosterone Gel|DRUG: Depo-Medroxyprogesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Molecular Cerebral Imaging in Incipient Dementia (MCI-ID) II
Status: WITHDRAWN
Conditions: Mild Cognitive Impairment
Interventions: PROCEDURE: Amyloid imaging|PROCEDURE: FDG-PET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: PK Study of IV and Oral Amisulpride in Subjects With Severe Renal Impairment
Status: COMPLETED
Conditions: Renal Disease, End Stage
Interventions: DRUG: Amisulpride IV|DRUG: Amisulpride Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treximet in the Treatment of Chronic Migraine
Status: COMPLETED
Conditions: Chronic Migraine
Interventions: DRUG: Sumatriptan/Naproxen Sodium|DRUG: Naproxen Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Food on the Pharmacokinetics of LPM3770164 Sustained-release Tablets
Status: NOT_YET_RECRUITING
Conditions: Huntington Disease|Tardive Dyskinesia
Interventions: DRUG: LPM3770164 sustained release tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and PK of NTM-1634 vs Placebo Administered Intravenously in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: NTM-1634|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Recombinant Bacterial ACE2 Receptors -Like Enzyme of B38-CAP and Isotretinoin Could be Promising Treatment for COVID-19 Infection- and Its Inflammatory Complications
Status: UNKNOWN
Conditions: COVID
Interventions: COMBINATION_PRODUCT: Recombinant Bacterial ACE2 receptors -like enzyme of B38-CAP (rbACE2) plus Aerosolized 13 cis retinoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of B I1356 (Linagliptin) vs. Placebo Added to Metformin Background Therapy in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: linagliptin|DRUG: linagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemotherapy for Locally Advanced Squamous Cell Cancer of the Head and Neck (SCCHN)
Status: COMPLETED
Conditions: Hypopharyngeal Cancer
Interventions: DRUG: neoadjuvant docetaxel/cisplatin/fluorouracil|DRUG: No treatment before definitive CCRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effectiveness of Fampridine in Improving Upper Limb Function in MS
Status: COMPLETED
Conditions: Secondary Progressive Multiple Sclerosis|Primary Progressive Multiple Sclerosis
Interventions: DRUG: Fampridine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interaction Between Immune Cells and Bacteria Associated With Periodontitis
Status: COMPLETED
Conditions: Periodontal Diseases|Periodontitis|Aggressive Periodontitis|Immunologic Disease|Microbial Disease|Periodontal Pocket|Inflammation|Inflammation Gum|Dysbiosis|Rheumatoid Arthritis|Generalized Aggressive Periodontitis|Generalized Chronic Periodontitis|Chronic Periodontitis
Interventions: OTHER: In vitro stimulation of blood with periodontitis-associated- and control bacteria|DIAGNOSTIC_TEST: Anti-CCP- and anti-P.g.-antibodies titers|GENETIC: Analysis of selected single nucleotide polymorphisms (SNPs)|DIAGNOSTIC_TEST: periodontitis-associated bacteria presence
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neoadjuvant Pembrolizumab for Unresectable Stage III and Unresectable Stage IV Melanoma
Status: COMPLETED
Conditions: Unresectable Malignant Neoplasm|Melanoma|Metastatic Melanoma|Stage IV Melanoma|Stage III Melanoma
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Bortezomib and Dexamethasone With or Without Cyclophosphamide in Patients With Relapsed or Not Controllable Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Dexamethasone|DRUG: Bortezomib|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate the Safety, Tolerability, And Pharmacokinetics Of PF-06266047 In Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Placebo|DRUG: PF-06266047
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Microvascular and Fibrosis Imaging Study
Status: COMPLETED
Conditions: Autoimmune Diseases|Sickle Cell Disease|Chronic Graft Versus Host Disease
Interventions: OTHER: Acoustic Radiation Force Impulse (ARFI)|OTHER: Laser Doppler Flowmetry (LDF)|OTHER: Laser Doppler Perfusion Imaging (LDI)|OTHER: Optical Coherence Tomography (OCT)|OTHER: Orthogonal Polarization Spectral Imaging (OPSI)|OTHER: Nail fold video capillaroscopy (NVC)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose Constraints for the Temporal Lobes of Intensity-modulated Radiotherapy Treatment Plans for Nasopharyngeal Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Injury; Temporal Region
Interventions: RADIATION: IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concurrent and Non-concurrent Chemo-radiotherapy or Radiotherapy Alone for Patients With Oligo-metastatic Stage IV Non-small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Stage IV (Oligo-metastases)|Non-small Cell Lung Cancer
Interventions: RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Dupilumab_Metastatic NSCLC
Status: RECRUITING
Conditions: Metastatic Non-small Cell Lung Cancer
Interventions: DRUG: Dupilumab|DRUG: PD-1/PD-L1 blockade
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of a New Prognostic Score for Adult Patients With RAS Wild-type mCRC Treated With Vectibix® and FOLFIRI or FOLFOX in First Line (VALIDATE)
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer|RAS Wild-type
Interventions: DRUG: Panitumumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nicotinamide Riboside Impact on Extracellular Nicotinamide Adenine Dinucleotide (NAD+)
Status: ACTIVE_NOT_RECRUITING
Conditions: NAD
Interventions: DIETARY_SUPPLEMENT: Niagen|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Phase II Study of AZD6244 (Mitogen-activated Protein Kinase Inhibitor) MEK-Inhibitor With Erlotinib in KRAS Wild Type Advanced Non-Small Cell Lung Cancer (NSCLC) and a Randomized Phase II Study of AZD6244 With Erlotinib in Mutant KRAS Adva...
Status: COMPLETED
Conditions: Non Small Cell Lung Carcinoma
Interventions: DRUG: AZD6244|DRUG: Erlotinib|DRUG: AZD6244 + Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib/II Clinical Study of Camrelizumab and Apatinib Plus GP in the Treatment of Advanced Biliary Tract Cancer
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Biliary Tract Cancer|Metastatic Biliary Tract Cancer
Interventions: DRUG: Camrelizumab and Apatinib Plus GP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patent Foramen Ovale (PFO) Closure at the Time of Endovascular Cardiac Electronic Device Implantation
Status: WITHDRAWN
Conditions: Foramen Ovale, Patent
Interventions: DRUG: Aspirin|DEVICE: Cardiovascular Implantable Device (CIED)|DEVICE: Gore Cardioform Septal Occluder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adoptive Autologous iNKT Cells for the Treatment of Progressed Hepatocellular Carcinoma Continuing on PD-1 Inhibitor Therapy
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: iNKT Cells|DRUG: PD-1|DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Single Ascending Oral Doses of INV-101 in Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Pharmacokinetic
Interventions: DRUG: INV-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Pharmacokinetic Drug Interactions and Safety of Ilaprazole and Aceclofenac
Status: COMPLETED
Conditions: Drug Interaction Potentiation
Interventions: DRUG: Ilaprazole|DRUG: Aceclofenac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Nitroglycerin Ointment, Fluorescent Angiography, and Incisional Negative Pressure Wound Therapy on Mastectomy Skin Flap Perfusion-Related Problems
Status: TERMINATED
Conditions: Perfusion; Complications
Interventions: DRUG: Nitroglycerin|DEVICE: Negative Pressure Wound Therapy/ Wound VAC|OTHER: Fluorescent Angiography with indocyanine-green (not to exceed 5mg/kg)|OTHER: No treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pilot Study Immunomonitoring Natural Killers Cells in Patients With Myeloid Malignancies Treated With Lenalidomide
Status: COMPLETED
Conditions: Acute Myeloid Leukemia or Myelodysplasic Syndrome
Interventions: PROCEDURE: Realization of 3 Blood samples during study during treatment with lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Clinical Trial of Novel Implantation Promoting Medium (EmbryoGlue) to Improve IVF Success Rates
Status: TERMINATED
Conditions: Embryo Implantation|Infertility
Interventions: OTHER: EmbryoGlue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Periocular Basal Cell Carcinoma (BCC): Permanent vs. Frozen Section Pathological Control
Status: UNKNOWN
Conditions: Basal Cell Carcinoma
Interventions: PROCEDURE: Permanent Section Control|PROCEDURE: Frozen Section Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Problem Solving Intervention Involving Employees at Risk of Sick Leave Due to Common Mental Disorders
Status: ACTIVE_NOT_RECRUITING
Conditions: Mental Disorders
Interventions: BEHAVIORAL: Problem solving intervention|BEHAVIORAL: Care as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Melatonin for Preventing POCD in Transurethral Prostate Resection Under Spinal Anesthesia
Status: UNKNOWN
Conditions: Melatonin|Cognitive Dysfunction|Postoperative Complications|Prostate Hyperplasia
Interventions: DIETARY_SUPPLEMENT: melatonin|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Coffee Mannooligosaccharides for Weight Management
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Coffee mannooligosaccharide|DIETARY_SUPPLEMENT: Coffee mannooligosaccharides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effectiveness of a Stress Reduction Intervention in Inflammatory Bowel Disease (IBD)
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases|Remission|Perceived Stress
Interventions: OTHER: Stress Reduction Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Blinatumomab as a Bridge to Allo-HSCT in HR BCP-ALL
Status: RECRUITING
Conditions: B-cell Acute Lymphoblastic Leukemia
Interventions: DRUG: Blinatumomab|OTHER: Conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare LY2963016 to Lantus After a Single Dose to Participants With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: LY2963016|DRUG: Lantus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quadratus Lumborum Block Versus Transversus Abdominus Plane Block for Pain Management After Donor Nephrectomy
Status: COMPLETED
Conditions: Kidney Donor
Interventions: PROCEDURE: QL Block|PROCEDURE: TAP Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Coronary De-novo Stenosis by a Sirolimus Coated Balloon or a Paclitaxel Coated Balloon Catheter
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: PTCA of coronary de novo lesion PCB|DEVICE: PTCA of coronary de novo lesion SCB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Breastfeeding Pillow on Breastfeeding Self-Efficacy and Postpartum Comfort in Women Who Had Cesarean
Status: COMPLETED
Conditions: Cesarean Section; Dehiscence|First Birth
Interventions: OTHER: using a breastfeeding pillow|OTHER: not using a breastfeeding pillow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion
Status: NOT_YET_RECRUITING
Conditions: Ischemia Reperfusion Injury|Peripheral Artery Disease
Interventions: DRUG: Vitamin B6 25 MG|DRUG: Vitamin B6 50 MG|DRUG: Vitamin B6 100 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Personalized Neoantigen Cancer Vaccine in Treatment Naïve, Asymptomatic Patients With IGHV Unmutated CLL.
Status: RECRUITING
Conditions: Lymphocytic Leukemia
Interventions: DRUG: NeoVax|DRUG: Cyclophosphamide|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK/PD Study of U-500 Regular Insulin
Status: COMPLETED
Conditions: Type 2 Diabetes|Insulin Resistance|High Insulin Requirements
Interventions: DRUG: U-500 insulin, 100 syringe units|DRUG: U-500 insulin, 200 syringe units
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Clinical Utility of Cell-free DNA (cfDNA) in Identifying Actionable Alterations and Minimal Residual Disease for Lymphoma Patients Across Community Centers in Texas
Status: RECRUITING
Conditions: Lymphoma
Interventions: DIAGNOSTIC_TEST: cell-free DNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of 5 Weeks of Treatment With BGG492 in Patients With Spasticity Due to Multiple Sclerosis
Status: WITHDRAWN
Conditions: Muscle Spasticity Due to Multiple Sclerosis
Interventions: DRUG: BGG492|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Grazoprevir (MK-5172) + Elbasvir (MK-8742) in Participants With Chronic Hepatitis C and Chronic Kidney Disease (MK-5172-052)
Status: COMPLETED
Conditions: Hepatitis C Virus
Interventions: DRUG: Grazoprevir|DRUG: Elbasvir|DRUG: Placebo to Grazoprevir|DRUG: Placebo to Elbasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of TQ-A3334 Combined With Entecavir in the Treatment of Chronic Hepatitis B
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: TQ-A3334|DRUG: Placebo|DRUG: Entecavir Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TEAS to Reduce Propofol Consumption During General Anesthesia
Status: COMPLETED
Conditions: Anesthesia
Interventions: OTHER: acupoint stimulation|OTHER: non-acupoint stimulation|OTHER: electrodes attached
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: STUDY ON THE EFFECTS OF PERIODONTAL TREATMENT ALONG WITH THE USE OF ANTIBIOTICS OVER HIGH SENSITIVE C-REACTIVE PROTEIN. RANDOMIZED CONTROLLED CLINICAL TRIAL.
Status: UNKNOWN
Conditions: Chronic Periodontitis
Interventions: DRUG: Scaling and root planing plus Azithromycin|DRUG: Scaling and root planing plus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Corticotomy and Micro-Osteoperforation During Canine Retraction
Status: COMPLETED
Conditions: Malocclusion, Class I/II
Interventions: PROCEDURE: Micro-Osteoperforations|PROCEDURE: Corticotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nigella Sativa in Atorvastatin Treated Hyperlipidaemia
Status: RECRUITING
Conditions: Hyperlipidemia
Interventions: DRUG: Nigella Sativa capsule 500mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Project Prepared: Risks, Roles and Relationships
Status: COMPLETED
Conditions: F01.145.802.845|F01.145.802.987
Interventions: BEHAVIORAL: Project Prepared|BEHAVIORAL: TEEN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity and Safety of Booster Immunization of COVID-19 Vaccine (Vero Cell), Inactivated (Omicron Variant) in Healthy People Aged 18 Years and Above
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: COVID-19 Vaccine (Vero cell), Inactivated (Omicron variant)|BIOLOGICAL: COVID-19 Vaccine (Vero cell), Inactivated (CZ strain)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy Plus Fluoxetine in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Anxiety Disorder|Depression|Fatigue|Lung Cancer
Interventions: DRUG: cisplatin|DRUG: fluoxetine|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Sofosbuvir From Heterosofir 400 mg F.C.T (Pharmed Healthcare, Egypt) & Sovaldi 400 mg F.C.T ( Gilead Sciences, Ireland)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Heterosofir|DRUG: Sovaldi
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Early Team Based Neuro-rehabilitation After Traumatic Brain Injury - a Pilot Study
Status: UNKNOWN
Conditions: Traumatic Brain Injury|Concussion, Brain
Interventions: BEHAVIORAL: Early team based neuro-rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Boosting Primary Care Awareness and Treatment of Childhood Hypertension
Status: TERMINATED
Conditions: Pediatric Hypertension
Interventions: BEHAVIORAL: Control condition|BEHAVIORAL: QIC with PCP and without subspecialist|BEHAVIORAL: QIC with Subspecialist|BEHAVIORAL: Hub and Spoke co-management|BEHAVIORAL: Sustainability of changes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics And Relative Bioavailability Study Of Oxycodone
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Oxycodone|DRUG: Oxycodone|DRUG: Oxycodone|DRUG: Oxycodone|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: ACURATE TF™ Transfemoral Aortic Bioprosthesis for Implantation in Patients With Severe Aortic Stenosis:CE-approval Cohort
Status: COMPLETED
Conditions: Symptomatic Aortic Stenosis
Interventions: DEVICE: ACURATE TF™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sofosbuvir + Ribavirin for 12 or 16 Weeks in Treatment Experienced Subjects With Chronic Genotype 2 or 3 HCV Infection (FUSION)
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: SOF|DRUG: RBV|DRUG: Placebo to match SOF|DRUG: Placebo to match RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess How ABBV-951 is Absorbed When Administered at Different Subcutaneous Sites of Adult Participants With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: ABBV-951
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: BIOLOGICAL: Sotatercept|OTHER: SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Responses to Pneumococcal Vaccination Among HIV-infected Subjects
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: (PV) 23-valent pneumococcal polysaccharide vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Study of Bicalutamide 1 x 50 mg Tablet in Healthy Subjects Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Bicalutamide|DRUG: Casodex®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Carboplatin and Paclitaxel With or Without Vorinostat in Treating Patients With Advanced Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Stage IIIA Non-Small Cell Lung Cancer|Stage IIIB Non-Small Cell Lung Cancer|Stage IV Non-Small Cell Lung Cancer
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Vorinostat|OTHER: Placebo|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Conscious Sedation for Epilepsy Surgery
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Remifentanil|DRUG: Dexmedetomidine|DRUG: Propofol|DRUG: Bupivacaine|DRUG: Lidocaine|DRUG: Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinical Investigation of the Next-Generation Intraocular Lens
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Investigational Intraocular Lens Device #1: TECNIS Model ZHR00|DEVICE: Investigational Intraocular Lens Device #2: TECNIS Model ZQR00|DEVICE: TECNIS Symfony® Extended Range of Vision Intraocular Lens: Model ZXR00
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intestinal Microbiota and Vitamin K Levels in PXE Patients (IMPROVE Study)
Status: UNKNOWN
Conditions: Pseudoxanthoma Elasticum
Interventions: DIAGNOSTIC_TEST: Fecal and blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Anterior Cruciate Ligament Pain Study
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Reconstruction
Interventions: DRUG: Ropivacaine 0.5%|DRUG: Percocet 7.5/325|DRUG: Naprosyn 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Incidence of Glaucoma-related Adverse Events in Pediatric Secondary Intraocular Lens Implantation
Status: RECRUITING
Conditions: Lens Implantation, Intraocular
Interventions: PROCEDURE: Secondary in-the-bag IOL fixation|PROCEDURE: Secondary ciliary sulcus IOL fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: TREE-2: Three Regimens of Eloxatin in Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: oxaliplatin|DRUG: fluoropyrimidine|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of AK117 (Anti-CD47) in Patients With Myelodysplastic Syndrome
Status: RECRUITING
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: AK117|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total Tumor Mapping (TTM) for Resectable Pancreatic Cancer
Status: WITHDRAWN
Conditions: Pancreatic Cancer|Resectable Pancreatic Cancer
Interventions: DRUG: Pimonidazole|PROCEDURE: Surgical Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Efficacy of Intravaginal Electrical Stimulation in Women With Idiopathic Overactive Bladder
Status: RECRUITING
Conditions: Urinary Bladder, Overactive
Interventions: DEVICE: intravaginal electrical stimulation added to bladder training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Camrelizumab in Combination With Neoadjuvant Chemotherapy for Operable Locally Advanced Head and Neck Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Head and Neck Cancer|Squamous Cell Carcinoma
Interventions: DRUG: PD-1 inhibitor|DRUG: Albumin Paclitaxel|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Primary Care Clinician Commitments to Choosing Wisely®
Status: COMPLETED
Conditions: Health Services Misuse|Physician's Practice Patterns|Guideline Adherence|Unnecessary Procedures|Health Care Costs
Interventions: BEHAVIORAL: Commitment invitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Non-interaction Study Between Pregabalin and Tramadol, Administered Individually or Combination, in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Fixed dose combination Pregabalin 150 mg / Tramadol 50 mg|DRUG: Pregabalin 150mg|DRUG: Tramadol 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT