pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Is Anesthetic Loss of Consciousness a Top Down or Bottom up Phenomenon. What Does the Neurologic Examination Say?.
Status: COMPLETED
Conditions: Anesthesia; Functional
Interventions: DIAGNOSTIC_TEST: FOUR coma scale and frontal espectrograpy evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial of Neoadjuvant and Adjuvant Nivolumab and BMS-813160 With or Without GVAX for Locally Advanced Pancreatic Ductal Adenocarcinomas.
Status: RECRUITING
Conditions: Locally Advanced Pancreatic Ductal Adenocarcinoma (PDAC)|Pancreatic Ductal Adenocarcinoma
Interventions: RADIATION: Stereotactic Body Radiation (SBRT)|DRUG: Nivolumab|DRUG: CCR2/CCR5 dual antagonist|DRUG: GVAX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benefit/Risk Evaluation of Insuman Implantable Versus Insuplant Using Medtronic MiniMed Implantable Pump System in Patients With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: HUMAN INSULIN (BIOSYNTHETIC)|DRUG: Insuplant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Fluconazole in Children With Autism Spectrum Disorder
Status: UNKNOWN
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Liraglutide on Endothelial Function in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: placebo|DRUG: glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Risedronate in Patients With Painful Periprosthetic Resorption of the Hip Prothesis
Status: TERMINATED
Conditions: Prosthesis Loosening
Interventions: DRUG: risedronate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spinal Cord Stimulation (SCS) for Amputees
Status: WITHDRAWN
Conditions: Somatosensory Perception Following Lower Limb Amputation
Interventions: DEVICE: 32 channel external stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Assess the Effect of Long-term Treatment With Voxelotor in Participants Who Have Completed Treatment in Study GBT440-031
Status: ACTIVE_NOT_RECRUITING
Conditions: Sickle Cell Disease
Interventions: DRUG: Voxelotor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Preterm Outcomes by Safeguarding Maternal Mental Health
Status: COMPLETED
Conditions: Depression|Child Development
Interventions: BEHAVIORAL: Problem Solving Education tailored to NICU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Exploratory Study of the Effects of Nivolumab Combined With Ipilimumab in Patients With Treatment-Naive Stage IV or Recurrent Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Tolerability of Andecaliximab as Monotherapy and in Combination With Chemotherapy in Participants With Advanced Solid Tumors
Status: COMPLETED
Conditions: Pancreatic Cancer|Non-small Cell Lung Cancer|Esophagogastric Cancer|Colorectal Cancer|Breast Cancer
Interventions: DRUG: Andecaliximab|DRUG: Gemcitabine|DRUG: Nab-paclitaxel|DRUG: Carboplatin|DRUG: Pemetrexed|DRUG: Leucovorin|DRUG: Oxaliplatin|DRUG: 5-FU|DRUG: Bevacizumab|DRUG: Irinotecan|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hans Kai: Impact of a Peer Lead Community Health Program on Behavior Change, Mental Health, Health Efficacy and Social Support Comparative Control Study
Status: WITHDRAWN
Conditions: Health Behavior
Interventions: OTHER: Hans Kai Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: To Demonstrate the Relative Bioavailability of Metformin HCL 500 mg Extended Release (XR) Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Type II Diabetes
Interventions: DRUG: Metformin HCL 500 mg Extended-Release Tablets, Geneva PTC|DRUG: Metformin HCL 500 mg Extended-Release Tablets, Geneva PTC|DRUG: GLUCOPHAGE XR 500 mg ER Tablets Bristol-Myers Squibb|DRUG: GLUCOPHAGE XR 500 mg ER Tablets Bristol-Myers Squibb
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety of D-TRANS Fentanyl With Naltrexone in Adult Patients With Chronic Pain and Who Are Opioid Tolerant
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DRUG: fentanyl; naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of an Investigational Drug to See How it Affects the People With Parkinson's Disease Complicated by Motor Fluctuations ("OFF" Episodes) Compared to an Approved Drug Used to Treat People With Parkinson's Disease Complicated by Motor Fluctuations ("OFF" Episodes)
Status: COMPLETED
Conditions: Motor OFF Episodes Associated With Parkinson's Disease
Interventions: DRUG: APL-130277|DRUG: subcutaneous apomorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: WT1 Peptide Vaccination in Acute Myeloid Leukemia (AML)
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: BIOLOGICAL: WT1 126-134 peptide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab and Interleukin-12 in Treating Patients With B-Cell Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Small Lymphocytic Lymphoma|Splenic Marginal Zone Lymphoma
Interventions: BIOLOGICAL: rituximab|BIOLOGICAL: recombinant interleukin-12|OTHER: laboratory biomarker analysis|OTHER: questionnaire administration|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Amino Acid Supplement During Acute Inflammation.
Status: COMPLETED
Conditions: Febrile Illness Acute|Inflammation|Metabolic Diseases
Interventions: BIOLOGICAL: E. coli endotoxin, US standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase II Randomized Study of Muromonab-CD3, Cyclosporine, Methylprednisolone, and Prednisone in Patients With Giant Cell Myocarditis
Status: COMPLETED
Conditions: Myocarditis|Giant Cell Myocarditis
Interventions: DRUG: Cyclosporine|DRUG: methylprednisolone|DRUG: Muromonab-CD3|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Additional Effects of Piriformis Stretch in the Management of Sacroiliac Joint Dysfunction
Status: RECRUITING
Conditions: Sacroiliac Joint
Interventions: PROCEDURE: Maitland mobilization|PROCEDURE: Piriformis stretch|PROCEDURE: Electrotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 177Lu-DOTA-EB-TATE in Patients With Advanced Neuroendocrine Tumors
Status: UNKNOWN
Conditions: Neuroendocrine Tumors
Interventions: DRUG: 177Lu-DOTA-EB-TATE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Photodynamic Therapy in the Treatment of Chronic Periodontitis
Status: UNKNOWN
Conditions: Chronic Periodontitis
Interventions: OTHER: Adjunctive Photodynamic Therapy|OTHER: Light-emitting diod Irradiation|OTHER: applying Photosensitizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Piezoelectric Device on Intraoperative Hemorrhage Control and Quality of Life
Status: ACTIVE_NOT_RECRUITING
Conditions: Periapical Lesion
Interventions: PROCEDURE: conventional surgery|PROCEDURE: piezoelectric device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Advanced Lung Non-Small Cell Carcinoma|Metastatic Lung Non-Small Cell Carcinoma|Stage III Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Carfilzomib|PROCEDURE: Computed Tomography|PROCEDURE: Echocardiography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Sotorasib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online Videodensitometric Assessment of Aortic Regurgitation in the Cath-Lab
Status: UNKNOWN
Conditions: Aortic Valve Insufficiency|Heart Valve Diseases|Regurgitation, Aortic|Paravalvular Aortic Regurgitation
Interventions: DIAGNOSTIC_TEST: Quantitative aortogram (videodensitometry)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Safety and Effectiveness of JNJ-54781532 in Patients With Moderately to Severely Active Ulcerative Colitis
Status: COMPLETED
Conditions: Colitis, Ulcerative
Interventions: DRUG: Placebo|DRUG: JNJ-54781532 25 mg once daily|DRUG: JNJ-54781532 75 mg once daily|DRUG: JNJ-54781532 150 mg once daily|DRUG: JNJ-54781532 75 mg twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-infective Effect of Non-surgical Treatment With and Without Photodynamic Therapy on Initial Peri-implantitis
Status: COMPLETED
Conditions: Peri-implantitis
Interventions: DEVICE: Photodynamic therapy|PROCEDURE: Mechanical debridement|DRUG: Irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pre-incision Versus Lapaorscopic-assisted Transversus Abdominis Plane (TAP) and Rectus Sheath Block for Post-Cholecystectomy Pain
Status: ENROLLING_BY_INVITATION
Conditions: Post Operative Pain
Interventions: PROCEDURE: Laparoscopic-assisted TAP block(LATAP) and Rectus Sheath block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Daily RAD001 in Combination With Mitomycin C in Patients With Advanced Gastric Cancer or Cancer of the Esophagogastric Junction
Status: COMPLETED
Conditions: Advanced Gastric Cancer|Advanced Cancer of the Esophagogastric Junction
Interventions: DRUG: RAD001 and MitomycinC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of SST-6007, a Topical Sildenafil Cream, Compared to Placebo in Women With Female Sexual Arousal Disorder
Status: COMPLETED
Conditions: Sexual Arousal Disorder
Interventions: DRUG: Placebo|DRUG: SST-6007
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sorafenib Tosylate Before and After Hepatic Arterial Chemoembolization With Doxorubicin Hydrochloride and Mitomycin C in Treating Patients With Localized Liver Cancer That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Liver Cancer
Interventions: DRUG: sorafenib tosylate, HACE : Doxorubicin Hydrochloride and Mitomycin C|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Bone Marrow Stem Cells in Middle Cerebral Artery Acute Stroke Treatment.
Status: COMPLETED
Conditions: Stroke, Acute|Infarction, Middle Cerebral Artery
Interventions: PROCEDURE: Infusion on autologous CD34+ stem cells into middle cerebral artery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: N-acetylcysteine for Renal Protection in Patients With Rheumatic Heart Disease Undergoing Valve Replacement
Status: COMPLETED
Conditions: Cardiac Surgery for Rheumatic Valvular Heart Disease|Renal Dysfunction
Interventions: DRUG: N-acetylcysteine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: T138067 Versus Doxorubicin in Chemotherapy-Naive, Unresectable, Hepatocellular Carcinoma Patients
Status: TERMINATED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: T138067 intravenous|DRUG: doxorubicin intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Based on PEEG and PET Study of Anxiolytic Treatment to Improve Cognitive Function in Patients With Alzheimer Disease
Status: UNKNOWN
Conditions: Alzheimer Disease|Cognitive Function
Interventions: DRUG: Tandospirone Citrate|DRUG: Donepezil Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Megestrol Acetate Plus Rosuvastatin in Young Women With Atypical Endometrial Hyperplasia
Status: COMPLETED
Conditions: Atypical Endometrial Hyperplasia
Interventions: DRUG: Megestrol Acetate|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Omega-3 Fatty Acid on Neurobehavioral Status of Children With Autism Spectrum Disorder: A Randomized, Double-Blind, Placebo Controlled Trial
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Omega 3 fatty acid|DRUG: Placebo of Omega-3 fatty acid softgel capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safer Births - Reducing Perinatal Mortality
Status: COMPLETED
Conditions: Fetal Heart Rate Abnormalities|Respiratory Depression|Birth Asphyxia|Neonatal Resuscitation
Interventions: DEVICE: Fetoscope, Fetal heart rate|DEVICE: Upright Resuscitator, Resuscitation|DEVICE: Doppler, Fetal heart rate|DEVICE: Standard Resuscitator, Resuscitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dendritic Cell-based Immunotherapy Combined With Low-dose Cyclophosphamide in Patients With Malignant Mesothelioma
Status: COMPLETED
Conditions: Malignant (Pleural) Mesothelioma
Interventions: BIOLOGICAL: DC + CTX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Effectiveness of Different Doses of Chrysalin in Adults Who Have a Broken Wrist
Status: TERMINATED
Conditions: Radius Fracture
Interventions: DRUG: Chrysalin|DRUG: Chrysalin|DRUG: Chrysalin|DRUG: Chrysalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Generic Mycophenolate Mofetil Safety Study for Prophylaxis in de Novo Renal Transplant Patients in Jordan
Status: COMPLETED
Conditions: Acute Transplant Rejection in Patients Receiving Allogeneic Renal Transplant
Interventions: DRUG: Mycophenolate Mofetil
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Surgery for Traumatic Optic Neuropathy
Status: UNKNOWN
Conditions: Traumatic Optic Neuropathy
Interventions: PROCEDURE: Optic canal and optic nerve sheath decompression|DRUG: methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Invitro Maturation of Oocytes for Patients With Polycystic Ovaries
Status: UNKNOWN
Conditions: Infertility|Polycystic Ovaries
Interventions: PROCEDURE: in vitro matuartion of oocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nebivolol, Lifestyle Modification and Arterial Stiffness
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Nebivolol|OTHER: Lifestyle Modification|OTHER: Nebivolol plus Lifestyle Modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Drug Interaction Study of Folic Acid and Oral Contraceptive Tablets Containing Norgestimate (NGM) /Ethinyl Estradiol (EE) in Healthy Women.
Status: COMPLETED
Conditions: Drug Interactions|Healthy|Pharmacokinetics
Interventions: DRUG: Norgestimate; Ethinyl Estradiol; Folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Acupuncture for Phonotraumatic Injuries
Status: UNKNOWN
Conditions: Phonotraumatic Injuries
Interventions: PROCEDURE: Traditional Chinese acupuncture|PROCEDURE: Placebo acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Timing of Repeat Voiding Trials After Outpatient Pelvic Floor Surgery
Status: COMPLETED
Conditions: Pelvic Organ Prolapse|Urinary Incontinence,Stress|Surgery
Interventions: DEVICE: Foley catheter - Early Voiding Trial|DEVICE: Foley catheter - Late Voiding Trial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Use of rTMS to Improve Theory of Mind Among Adults With Autism and Asperger's Disorder
Status: COMPLETED
Conditions: Autistic Disorder|Asperger's Disorder
Interventions: DEVICE: Deep rTMS|DEVICE: Sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety, Tolerability and Analgesic Efficacy of SAF312 in Postoperative Dental Pain Patients
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: SAF312A|DRUG: Placebo|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy of Risankizumab Compared to FUMADERM® in Subjects With Moderate to Severe Plaque Psoriasis Who Are Naïve to and Candidates for Systemic Therapy
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Fumaderm|DRUG: risankizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interventions to Decrease Heat Stress Among Latinx Farmworkers in Idaho
Status: WITHDRAWN
Conditions: Environmental Exposure
Interventions: OTHER: Interventions to Decrease Heat Stress among Latinx Farmworkers in Idaho
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Impact of Oral Diets on Postoperative Fluid Collection
Status: UNKNOWN
Conditions: Postoperative Complications
Interventions: DIETARY_SUPPLEMENT: Immunonutrition|DIETARY_SUPPLEMENT: High-protein nutrition|DIETARY_SUPPLEMENT: Standard nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of E/C/F/TAF (Genvoya®) in HIV-1/Hepatitis B Co-infected Adults
Status: COMPLETED
Conditions: HIV|HBV
Interventions: DRUG: E/C/F/TAF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Tin Mesoporphyrin vs Phototherapy for Hyperbilirubinemia in Premature Newborns
Status: COMPLETED
Conditions: Hyperbilirubinemia
Interventions: DRUG: tin mesoporphyrin|PROCEDURE: Phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Recovery Following Desflurane Versus Sevoflurane for Outpatient Urologic Surgery in Elderly Females
Status: COMPLETED
Conditions: Ureteral Stent Occlusion|Exposure Laser|Ureterostomy; Functional Disturbance|Vaginal Diseases|Injury of Bladder|Excessive Repair|Calculi
Interventions: DRUG: Desflurane|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Pretreatment Dexamethazone on Pain and Success of Nerve Block
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Dexamethasone Oral Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Molecularly Targeted Radionuclide Therapy Via the Integrin Alphavbeta6
Status: RECRUITING
Conditions: Metastatic Nonsmall Cell Lung Cancer
Interventions: DRUG: [68Ga]Ga DOTA-5G and [177Lu]Lu DOTA-ABM-5G.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Approach to Uterine Septum
Status: RECRUITING
Conditions: Uterine Septum|Surgical Complication|Septum; Uterus|Treatment Side Effects|Treatment
Interventions: PROCEDURE: Removal of uterine septum with hysteroscopic scissors without electrosurgery.|PROCEDURE: Hysteroscopic septoplasty utilizing bipolar electrosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Different Types of Stretching on Range of Motion, Pain and Function in Elbow Limitation
Status: COMPLETED
Conditions: Postoperative Pain|Elbow Fracture|Stiffness of Elbow, Not Elsewhere Classified
Interventions: OTHER: PNF stretching|OTHER: Static Stretching|OTHER: Exercise|OTHER: Cold Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture to Reduce Anxiety in Alzheimer's Disease (AD) and AD Related Dementias
Status: TERMINATED
Conditions: Alzheimer's Dementia With Behavioral Disturbance
Interventions: DEVICE: Acupuncture needle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Functional Precision Oncology to Predict, Prevent, and Treat Early Metastatic Recurrence of TNBC
Status: RECRUITING
Conditions: Breast Cancer Recurrent
Interventions: OTHER: Functional Precision Oncology
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Spontaneous Baroreflex Sensitivity in Carriers of Implantable Cardioverter Defibrillators: Association With Disorders of the Ventricular Heart Rate. Case-control Study
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: OTHER: Baroreflex assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of To Be Marketed (TBM) Cholic Acid Capsules Used to Treat Children With Inborn Errors of Bile Acid Synthesis
Status: COMPLETED
Conditions: Inborn Errors of Bile Acid Synthesis
Interventions: DRUG: Cholic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temozolomide With or Without Veliparib in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma|Gliosarcoma
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Placebo Administration|OTHER: Quality-of-Life Assessment|DRUG: Temozolomide|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of The Immediate Effect of Myofascial Release Application in Patients With Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low-back Pain
Interventions: BEHAVIORAL: Myofascial release|BEHAVIORAL: Classical massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Pilot Study to Assess the Feasibility of Switching, Individuals Receiving Atripla With Continuing Central Nervous System (CNS) Toxicity, to a Fixed Dose Combination of Tenofovir/Emtricitabine/Rilpivirine
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: tenofovir/emtricitabine/rilpivirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Efficacy of Perioperative Chemotherapy With Docetaxel, Cisplatin and Capecitabine (DCX) in Patients With Gastro-esophageal Cancer
Status: UNKNOWN
Conditions: Gastric Cancer|Esophageal Cancer
Interventions: DRUG: Docetaxel, Cisplatin, Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rivaroxaban vs. Warfarin for Post Cardiac Surgery Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation|Stroke|Bleeding
Interventions: DRUG: Rivaroxaban|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Primary Care Community Partnerships to Prevent Diabetes
Status: COMPLETED
Conditions: Hyperglycemia|Obesity|Diabetes Mellitus
Interventions: BEHAVIORAL: Dietitian Counseling Alone|BEHAVIORAL: Dietitian Plus Community Group Lifestyle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CLINTERVENTIONAL Trial: Impact of Clinical Consultations and Audiovisual Tools in Interventional Radiology
Status: RECRUITING
Conditions: Interventional Radiology|Physician-Patient Relations|Communication|Physician's Practice Patterns|Patient Satisfaction
Interventions: OTHER: Pre-procedural consultation and audiovisual tools
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Drug Interactions Between Voriconazole and Atazanavir Coadministered as Atazanavir/Ritonavir in Healthy Participants
Status: COMPLETED
Conditions: Human Immunodeficiency Virus Type 1 (HIV-1)|HIV Infections
Interventions: DRUG: Voriconazole|DRUG: Atazanavir|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors
Status: RECRUITING
Conditions: Bladder Adenocarcinoma|Bladder Clear Cell Adenocarcinoma|Bladder Mixed Adenocarcinoma|Bladder Neuroendocrine Carcinoma|Bladder Small Cell Neuroendocrine Carcinoma|Bladder Squamous Cell Carcinoma|Chromophobe Renal Cell Carcinoma|Collecting Duct Carcinoma|Invasive Bladder Giant Cell Urothelial Carcinoma|Invasive Bladder Lymphoepithelioma-Like Carcinoma|Invasive Bladder Nested Urothelial Carcinoma|Invasive Bladder Plasmacytoid Urothelial Carcinoma|Invasive Bladder Sarcomatoid Urothelial Carcinoma|Invasive Bladder Urothelial Carcinoma|Kidney Medullary Carcinoma|Large Cell Neuroendocrine Carcinoma|Malignant Testicular Leydig Cell Tumor|Malignant Testicular Sertoli Cell Tumor|Metastatic Bladder Carcinoma|Metastatic Bladder Clear Cell (Glycogen-Rich) Urothelial Carcinoma|Metastatic Bladder Giant Cell Urothelial Carcinoma|Metastatic Bladder Large Cell Neuroendocrine Carcinoma|Metastatic Bladder Lipid-Rich Urothelial Carcinoma|Metastatic Bladder Micropapillary Urothelial Carcinoma|Metastatic Bladder Plasmacytoid Urothelial Carcinoma|Metastatic Bladder Sarcomatoid Urothelial Carcinoma|Metastatic Bladder Small Cell Neuroendocrine Carcinoma|Metastatic Bladder Squamous Cell Carcinoma|Metastatic Chromophobe Renal Cell Carcinoma|Metastatic Kidney Medullary Carcinoma|Metastatic Malignant Genitourinary System Neoplasm|Metastatic Papillary Renal Cell Carcinoma|Metastatic Penile Carcinoma|Metastatic Prostate Small Cell Neuroendocrine Carcinoma|Metastatic Sarcomatoid Renal Cell Carcinoma|Metastatic Urethral Carcinoma|Papillary Renal Cell Carcinoma|Sarcomatoid Renal Cell Carcinoma|Stage IV Bladder Cancer AJCC v8|Stage IV Penile Cancer AJCC v8|Stage IV Renal Cell Cancer AJCC v8|Stage IV Urethral Cancer AJCC v8|Stage IVB Prostate Cancer AJCC v8|Urachal Adenocarcinoma|Urethral Clear Cell Adenocarcinoma
Interventions: PROCEDURE: Bone Scan|DRUG: Cabozantinib S-malate|PROCEDURE: Computed Tomography|BIOLOGICAL: Ipilimumab|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Nivolumab|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AIMHI NT Relapse Prevention Trial
Status: UNKNOWN
Conditions: Schizophrenia|Schizoaffective Disorder|Psychoses, Substance Induced|Depression|Bipolar Disorder
Interventions: BEHAVIORAL: Motivational Interview with care plan and education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Asymmetric Subthalamic Deep Brain Stimulation for Axial Motor Dysfunction in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: Asymmetric STN-DBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OUD Smartphone Services
Status: RECRUITING
Conditions: Opioid-Related Disorders|Drug Abuse
Interventions: BEHAVIORAL: Contingency management|BEHAVIORAL: Cognitive-Behavior Therapy Modules|BEHAVIORAL: Peer Contingency Management (CM) Guide|BEHAVIORAL: Drug testing|BEHAVIORAL: Wellness modules|BEHAVIORAL: Peer technical support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Using Reconsolidation Blockade to Treat Trauma Related Disorders After Paris Attacks: an Effectiveness Study
Status: COMPLETED
Conditions: Post-traumatic Stress Disorder
Interventions: DRUG: β-adrenergic blocker propranolol|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Frequency of Self-performed Mechanical Control of Plaque
Status: UNKNOWN
Conditions: Gingivitis|Oral Health
Interventions: BEHAVIORAL: Frequency of mechanical control of plaque (12h)|BEHAVIORAL: Frequency of mechanical control of plaque (24h)|BEHAVIORAL: Frequency of mechanical control of plaque (48h)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose:
Clinical trial: Evaluating Taste and Health Messaging in Short Nutrition Education Videos to Improve Diet Quality
Status: NOT_YET_RECRUITING
Conditions: Behavior, Health
Interventions: OTHER: Videos: Taste messaging focused|OTHER: Videos: Health messaging focused
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)
Status: NOT_YET_RECRUITING
Conditions: Lung Non-Small Cell Carcinoma
Interventions: BIOLOGICAL: Amivantamab|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Investigating Upfront Adaptive Immunotherapy Approach in Children, Adolescent and Young Adult (CAYA) Patients With Replication-Repair Deficient (RRD) High-Grade Gliomas (HGG)
Status: NOT_YET_RECRUITING
Conditions: High Grade Glioma|Replication Repair Deficient
Interventions: DRUG: Nivolumab|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of RTH258 Versus Aflibercept - Study 1
Status: COMPLETED
Conditions: Neovascular Age-Related Macular Degeneration|Choroidal Neovascularization
Interventions: DRUG: Brolucizumab ophthalmic solution|DRUG: Aflibercept ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cold Milk for Dysphagia in Preterm Infants
Status: COMPLETED
Conditions: Dysphagia of Newborn
Interventions: OTHER: Standard room temperature (RTS) feeding of milk/formula|OTHER: Cold temperature (CS, at 4-9°C) of milk/formula
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Therapeutic Effects of Vaginal Repair With Leuprorelin and Vaginal Repair in the Treatment of Cesarean Section Scar Defect
Status: RECRUITING
Conditions: Cesarean Section; Dehiscence
Interventions: DRUG: Leuprorelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Margin-Intense Combo Therapy in Pts w/Potentially Resectable Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: gemcitabine hydrochloride|RADIATION: stereotactic body radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Safety Behaviors in Exposure Therapy for Arachnophobia
Status: COMPLETED
Conditions: Specific Phobia|Arachnophobia|Spider Phobia
Interventions: BEHAVIORAL: Exposure with faded safety behaviors|BEHAVIORAL: Exposure without safety behaviors|BEHAVIORAL: Exposure with unfaded safety behaviors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation of STTR Strategies Among People Who Inject Drugs in Malaysia
Status: RECRUITING
Conditions: HIV Seropositivity|Opioid-use Disorder
Interventions: OTHER: Enhanced usual care (EUC)|BEHAVIORAL: Peer-based counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Individualized M(X) Drug-resistant TB Treatment Strategy Study
Status: TERMINATED
Conditions: Tuberculosis, Multidrug-Resistant
Interventions: DRUG: Individualized TB treatment with multiple drugs|DRUG: Standardized TB treatment with multiple drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Procyanidine on Semen Parameters and DNA Fragmentation Index During Cryopreservation of Abnormal Human Semen Samples
Status: COMPLETED
Conditions: Spermatogenesis and Semen Disorders|DNA Double Strand Break
Interventions: DIETARY_SUPPLEMENT: procyanidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intrusive Reexperiencing: The Role of Working Memory Capacity and Thought Suppression
Status: COMPLETED
Conditions: Memory
Interventions: OTHER: Show distressing movie and tell half of the two study groups to suppress memories of the movie
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: EPIC (Evaluating Perioperative Ischemia Reduction by Clonidine)
Status: UNKNOWN
Conditions: Heart Disease
Interventions: DRUG: clonidine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Exercise Training in Patients With Pulmonary Hypertension
Status: RECRUITING
Conditions: Hypertension, Pulmonary
Interventions: BEHAVIORAL: respiratory and exercise therapy|BEHAVIORAL: respiratory and exercise therapy with supplemental oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-Label,Single-Arm Pilot Study to Evaluate the Pharmacodynamics, Pharmacokinetics, Safety, and Preliminary Efficacy of CC1004 in Subjects With Severe Plaque Type Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: CC10004
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Responses of Dexmedetomidine, Lidocaine or Propofol Infusions During Laparoscopic Cholecystectomy
Status: RECRUITING
Conditions: Hemodynamic Responses|Laparoscopic Cholecystectomy|Dexmedetomidine|Lidocaine|Propofol
Interventions: DRUG: Dexmedetomidine|DRUG: Propofol|DRUG: Lidocain|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of the Peregrine Drivable ENT Scope for Endoscopy of the Paranasal Sinuses
Status: TERMINATED
Conditions: Sinus Problem
Interventions: DEVICE: Peregrine Drivable ENT Scope|DEVICE: Standard 30° 4mm Endoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Fluzoparib and Abiraterone in the preSurgery Treatment of Prostate Cancer: FAST Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: High-risk Prostate Cancer|Neoadjuvant Therapy
Interventions: DRUG: Abiraterone acetate|DRUG: Fluzoparib|DRUG: Prednisone|DRUG: Androgen deprivation therapy|PROCEDURE: Radical Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RL-1 Novel Human-derived Bio-artificial Liver Treatment in Patients of HBV Related ACLF
Status: UNKNOWN
Conditions: Hepatitis B|Acute-On-Chronic Liver Failure
Interventions: OTHER: Plasma exchange|OTHER: RL-1 Novel Human-derived Bio-artificial Liver Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Adding E2 to P4 Luteal Support In High Responder Long Gn-RH Agonist ICSI Cycles Detrimental to Outcome? RCT
Status: COMPLETED
Conditions: IVF|Infertility
Interventions: DRUG: estradiol plus progesterone 100 mg IM injection|DRUG: Progesterone IM of 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating BSI-201 in Combination With Chemotherapeutic Regimens in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Tumors
Interventions: DRUG: bsi-201 + topotecan|DRUG: bsi-201 + temozolomide|DRUG: bsi-201 + gemcitabine|DRUG: bsi-201 + carboplatin/paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Decision Aid on Decision Making for the Treatment of Pelvic Organ Prolapse
Status: UNKNOWN
Conditions: Decisional Conflict
Interventions: OTHER: Pelvic organ prolapse decision aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of LEVI-04 in Patients With Osteoarthritis of the Knee
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain|Osteo Arthritis Knee|Knee Osteoarthritis|Arthritis|Joint Diseases|Musculoskeletal Diseases|Rheumatic Diseases
Interventions: DRUG: LEVI-04|OTHER: Placebo:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint Elderly
Status: UNKNOWN
Conditions: Subjective Cognitive Complaint|Activities Daily Living|Dementia|Alzheimer Disease|Neurodegenerative Diseases|Functionality|Gait Disorders, Neurologic|Geroscience
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mild-dose IMRT for Early-staged Extranodal Nasal-type NK/T-cell Lymphoma With CR Tumor After GELOX Chemotherapy
Status: UNKNOWN
Conditions: Lymphoma,|Non-Hodgkin Lymphoma,|Extranodal NK/T-cell Lymphoma,Nasal-type,
Interventions: RADIATION: Mild-dose IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea
Status: RECRUITING
Conditions: Obstructive Sleep Apnea|Spinal Cord Injuries
Interventions: OTHER: Mild intermittent hypoxia|OTHER: Sham protocol|OTHER: Continuous positive airway pressure (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Pudendal Nerve Stimulation On Leak Point Pressure In Women Urodynamic Early Feasibility Study
Status: TERMINATED
Conditions: Urinary Incontinence
Interventions: DIAGNOSTIC_TEST: Urodynamic testing with and without pudendal nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: ENB Vs. Conventional Bronchoscopy With Fluoroscopy for Safe and Effective Biopsy of Pulmonary Lesions
Status: UNKNOWN
Conditions: Lung Neoplasms|Pulmonary Neoplasm
Interventions: DEVICE: ENB with image-guided lung biopsy|PROCEDURE: Conventional Bronchoscopy guided by Fluoroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treatment of Impulsive Aggression in Subjects With ADHD in Conjunction With Standard ADHD Treatment (CHIME 4)
Status: TERMINATED
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: DRUG: SPN-810
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Extension Study to Determine the Persistence of Tick-borne Encephalitis (TBE)-Specific Antibody Responses Among Children and Adolescents Previously Immunized Against TBE
Status: COMPLETED
Conditions: Tick Borne Encephalitis (TBE)
Interventions: OTHER: Serology blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Estradiol/Norethindrone Acetate Tablets, 1/0.5 mg Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Estradiol/Norethindrone acetate|DRUG: Activella®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: NB2013-HR German (GPOH) / Dutch (DCOG) Trial
Status: TERMINATED
Conditions: Neuroblastoma
Interventions: DRUG: antibody ch14.18|DRUG: GM-CSF|DRUG: IL-2 i.v.|DRUG: IL-2 s.c.|DRUG: Retinoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Effects Inclusive Cognitive Impact and Possibilities to Individually Adjusted Treatment in Patients With Intracranial Tumors With Clinical, Neuropsychological and Imaging Parameters
Status: COMPLETED
Conditions: Intracranial Tumor
Interventions: OTHER: MRI, neuropsychological evaluation, blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC