pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Effects of Light on Glucose Metabolism
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Glucose Intolerance|Prediabetic State
Interventions: BEHAVIORAL: Exposure to bright light during the day|BEHAVIORAL: Exposure to dim light during the day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interest of elastoFRM With Force Measure by MRI on Patients With Hepatocellular Cancer
Status: COMPLETED
Conditions: Hepatocellular Cancer
Interventions: RADIATION: IRM with a 5-minute- additional sequence to measure FRM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Simultaneous or Sequential Combination of Physical and Cognitive Training
Status: COMPLETED
Conditions: Healthy Older Adults
Interventions: DEVICE: physical training concurrent with cognitive training|DEVICE: physical training followed by cognitive training|DEVICE: physical training without cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Physiologic Parameters to Study the Mechanism of Action of the Lung Volume Reduction Coil in Subjects With Homogeneous Emphysema
Status: COMPLETED
Conditions: Emphysema
Interventions: DEVICE: Lung Volume Reduction Coil (LVRC) (PneumRx, Inc.)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arsenic Trioxide, Thalidomide, Dexamethasone, and Ascorbic Acid in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DIETARY_SUPPLEMENT: ascorbic acid|DRUG: arsenic trioxide|DRUG: dexamethasone|DRUG: thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accuracy of Non-Invasive Blood Pressure Measurements at the Arm, Calf , and Finger
Status: COMPLETED
Conditions: Hypotension and Shock|Hypertension|Intensive Care Unit
Interventions: DEVICE: Combined non-invasive intermittent (oscillometric arm cuff), non-invasive continuous (finger cuff and ClearSight device), and invasive continuous (intra-arterial catheter) BP measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Metformin as a Chemoprevention Agent in Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Neoplasms|Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Metformin|OTHER: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparative Study of the Effects of Dry Needling and Botulinum Toxin Type A as a Treatment for Lower Limb Post-stroke Spasticity
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: DRUG: Botulinum toxin type A|OTHER: Dry Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Frequency of Hyperparathyroidism in Postmenopausal Osteoporosis and Its Treatment
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis|Postmenopause|Hyperparathyroidism, Secondary|Hypovitaminosis D|Hyperparathyroidism, Primary
Interventions: DRUG: Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Phase 1/2 Open-Label Trial of PR104 and Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC)
Status: TERMINATED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: PR104 550 mg/m^2 + sorafenib|DRUG: PR104 770 mg/m^2 + sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Culturally-Targeted COVID-19 Communication and SARS-CoV-2 Antibody Testing Evaluation and Uptake
Status: COMPLETED
Conditions: SARS-CoV2 Infection
Interventions: BEHAVIORAL: Culturally Targeted SARS-CoV-2 Communication|BEHAVIORAL: General SARS-CoV-2 Communication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: A Phase 1, Single- and Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MEDI4166 in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: BIOLOGICAL: MEDI-4166|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Progressive Resistance Training Compared to Neuromuscular Exercises on Knee Kinematics
Status: COMPLETED
Conditions: Dynamic Knee Valgus|Injury Prevention
Interventions: OTHER: Neuromuscular training exercises|OTHER: Hip abductors muscular strength exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Immediate and Longterm Immune Responses of UK Infants and Young Children to a Booster Dose of Hib Vaccine
Status: COMPLETED
Conditions: Haemophilus Influenzae Type b
Interventions: BIOLOGICAL: Hib conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: OTX-15-002: A Phase 3 Study Evaluating the Safety and Efficacy of OTX-DP for the Treatment of Chronic Allergic Conjunctivitis
Status: COMPLETED
Conditions: Chronic Allergic Conjunctivitis
Interventions: DRUG: Dexamethasone|OTHER: Placebo Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of CK-2127107 on Physical Function in Subjects With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Reldesemtiv|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnosing Respiratory Disease in Children Using Cough Sounds
Status: COMPLETED
Conditions: Pneumonia|Bronchiolitis|Asthma|Croup|Upper Respiratory Tract Infection|Lower Respiratory Tract Infection|Reactive Airway Disease
Interventions: OTHER: Recording of Infants and Children's Cough Sounds
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety and the Effects of Risperidone Compared With Other Atypical Antipsychotic Drugs on the Growth and Sexual Maturation in Children
Status: COMPLETED
Conditions: Schizophrenia|Bipolar Disorder|Autistic Disorder|Conduct and Other Disruptive Behavior Disorders
Interventions: DRUG: Risperidone|DRUG: Other atypical antipsychotic drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ad Hoc Percutaneous Coronary Intervention Study in Acute Coronary Syndrome Patients
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NoAL (HPMC) in Combination With Oxymetazoline in Patients With Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Oxymetazoline|OTHER: Hydroxyl-propyl-methyl cellulose powder|OTHER: Placebo (lactose powder)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on the Effects of Exoskeleton Robot Walking Training on Adolescents With Cerebral Palsy: A Preliminary Study
Status: NOT_YET_RECRUITING
Conditions: Cerebral Palsy|Gait Disorders, Neurologic|Gait Disorders in Children
Interventions: DEVICE: pediatric/adolescent exoskeleton walking system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Intravenous Lidocaine to Supress of Cough Reflex During Anesthesia Emergence
Status: UNKNOWN
Conditions: Cough
Interventions: DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of Bimodal Stimulation Device Compliance and Satisfaction in Individuals With Tinnitus
Status: ACTIVE_NOT_RECRUITING
Conditions: Tinnitus
Interventions: DEVICE: Lenire bimodal stimulation device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: TMS for Inhibition Enhancement in Schizophrenia
Status: NOT_YET_RECRUITING
Conditions: Schizophrenia
Interventions: DEVICE: repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of Oral Apremilast in the Treatment of Alopecia Areata at the Tertiary Care Hospital, Karachi.
Status: COMPLETED
Conditions: Alopecia Areata
Interventions: DRUG: Apremilast 30mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of ALK-001 in Geographic Atrophy
Status: ACTIVE_NOT_RECRUITING
Conditions: Geographic Atrophy|Age Related Macular Degeneration|AMD|Atrophy, Geographic
Interventions: DRUG: ALK-001 oral capsule|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a Monovalent Inactivated Influenza H3N2 Variant (H3N2v) Vaccine in Adult and Elderly Populations
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza A/H3N2 variant Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sapanisertib, Carboplatin, and Paclitaxel in Treating Patients With Recurrent or Refractory Malignant Solid Tumors
Status: COMPLETED
Conditions: Recurrent Malignant Solid Neoplasm|Refractory Malignant Solid Neoplasm
Interventions: DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Sapanisertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Florbetapir (18F) Positron Emission Tomography (PET) Imaging in Japan of Healthy Volunteers, Patients With Mild Cognitive Impairment (MCI) and Patients With Alzheimer's Disease (AD)
Status: COMPLETED
Conditions: Alzheimer's Disease|Mild Cognitive Impairment
Interventions: DRUG: florbetapir (18F)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis
Status: TERMINATED
Conditions: Herpes Simplex Keratitis
Interventions: PROCEDURE: Corneal sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Does Pancreatic Stent Decrease the Risk of Pancreatitis After Pancreatic Sphincterotomy for Difficult Cannulation?
Status: RECRUITING
Conditions: Endoscopic Retrograde Cholangiopancreatography
Interventions: DEVICE: Biliary cannulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Self-adhesive Hybrid Resin Composite Compared to a Traditional Composite Resin in Restorations of NCCLs
Status: RECRUITING
Conditions: Tooth Restoration
Interventions: DEVICE: Surefil one|DEVICE: Venus Pearl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D3 in Sensory Recovery After Digital NERVe Suture (D3NERV).
Status: UNKNOWN
Conditions: Digital Nerve Injury
Interventions: DRUG: Cholecalciferol|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Treatment of Uveitic Cystoid Macular Edema With Topical Interferon Gamma
Status: COMPLETED
Conditions: Uveitis
Interventions: DRUG: Interferon Gamma 1-b
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of PCR-CRISPR/Cas12a on the Early Anti-infective Schemes in Patients With Open Air Pneumonia
Status: UNKNOWN
Conditions: Severe Sepsis
Interventions: DIAGNOSTIC_TEST: PCR-CRISPR／Cas12a detection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Atrial Fibrosis Surface Area on the Occurrence of Atrial Fibrillation in Patients With Ischemic Stroke of Undetermined Origin: a Prospective Cardiac MRI Pilot Study.
Status: RECRUITING
Conditions: Stroke|Implantation of an Implantable Cardiac Monitor
Interventions: OTHER: Cardiac MRI (with contrast agent)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Single Rising Dose Study (Intravenous Infusion and Subcutaneous Injection) of BI 655064 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Placebo to BI 655064|DRUG: Placebo to BI 655064|DRUG: BI 655064|DRUG: BI 655064
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ceftobiprole in Patients With Fever and Neutropenia.
Status: TERMINATED
Conditions: Fever|Neutropenia|Gram-positive Bacterial Infections|Pseudomonas Infection
Interventions: DRUG: Ceftobiprole Medocaril|DRUG: Cefepime with or without vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Subgingival Microbiota Following Mechanical Treatment and it's Effect on Peri-implant Sub-mucosa in Periodontitis Patients
Status: COMPLETED
Conditions: Aggressive Periodontitis, Generalized
Interventions: PROCEDURE: mechanical treatment(mainly scaling and root planing), periodontal surgery(if indicated), implant placement.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial to Evaluate the Effectiveness of Memory Training Workshops in People From 65 to 80 Years
Status: COMPLETED
Conditions: Memory Loss|Age-Related Memory Disorders
Interventions: BEHAVIORAL: Memory Training Workshop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: SBRT for Oligo-metastatic Lesions After Systemic Treatment of Primary Metastatic Nasopharyngeal Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Nasopharyngeal Carcinoma|Metastasis|Stereotactic Body Radiation Therapy
Interventions: RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Double-blind, Randomized, Multicenter, Cross-over Study to Compare the Effect of Creon N and Creon® on Fat Digestion in Subjects ≥ 12 Years of Age With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis
Status: COMPLETED
Conditions: Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis
Interventions: DRUG: Creon®|DRUG: Creon N
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Triathlon - a New Total Knee Prosthesis System - Triathlon vs. Duracon
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Knee
Interventions: DEVICE: Cemented Triathlon total knee system|DEVICE: Duracon total knee system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Trial of Dextroamphetamine for Methamphetamine Dependence
Status: COMPLETED
Conditions: Methamphetamine Addiction
Interventions: DRUG: Dextroamphetamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Laser Therapy in Gynaecology
Status: UNKNOWN
Conditions: Herpes Genitalis|Genital Wart|Lichen Sclerosus|Cervical Intraepithelial Neoplasia|Labial Reduction Surgery|Episiotomy Scar|Bartholin Cyst|Hidradenitis Suppurativa
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Behavioral Telehealth in Low-resource Primary Care Settings for Anxiety and Depression in Youth
Status: ENROLLING_BY_INVITATION
Conditions: Depression, Anxiety
Interventions: BEHAVIORAL: STEP-UP (transdiagnostic behavioral therapy for pediatric anxiety and depression)|BEHAVIORAL: ARC (assisted referral to community care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Divarasib|DRUG: Pembrolizumab|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhanced Perioperative Care for the Prevention of Colorectal Anastomotic Leakage
Status: UNKNOWN
Conditions: Anastomotic Leak Small Intestine|Anastomotic Leak Large Intestine|Anastomotic Leak Rectum|Intraoperative Awareness
Interventions: OTHER: Enhanced perioperative care protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of an Intramuscular A/H5N1 Inactivated, Split Virion Pandemic Influenza Vaccine in Children
Status: COMPLETED
Conditions: Influenza|Orthomyxoviridae Infections|Orthomyxovirus Infections
Interventions: BIOLOGICAL: A/H5N1 Inactivated, Split Virion Pandemic Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase II Study of Florbetaben (BAY 94-9172) PET Imaging for Detection/Exclusion of Cerebral β-amyloid in Patients With Probable Alzheimer's Disease Compared to Healthy Volunteers
Status: COMPLETED
Conditions: Alzheimer Disease|Amyloid Beta-Protein
Interventions: DRUG: Florbetaben (BAY94-9172)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pain and Microbial Reduction of Antimicrobial Corticosteroid Mixture Versus Cryotherapy in Necrotic Teeth
Status: NOT_YET_RECRUITING
Conditions: Dental Pulp Necrosis
Interventions: PROCEDURE: Local anaesthetic injection of 4% articaine with 1:100000 epinephrine|PROCEDURE: Tooth isolation|PROCEDURE: Access cavity preparation|PROCEDURE: Root canal shaping and cleaning|PROCEDURE: Final irrigation with antimicrobial-corticosteroid mixture|PROCEDURE: Final irrigation with cold saline|PROCEDURE: Temporary restoration and patient's instructions|PROCEDURE: Root canal obturation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer
Status: COMPLETED
Conditions: Mucositis|Solid Tumors|Stomatitis|Head and Neck Cancer|Squamous Cell Carcinoma
Interventions: DRUG: Placebo|DRUG: palifermin|DRUG: cisplatin chemotherapy|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Vigabatrin ORPHELIA Pharma 500mg Soluble Tablets and SabrilTM 500mg Granules for Oral Administration
Status: COMPLETED
Conditions: Therapeutic Equivalency
Interventions: DRUG: VGB-ST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib in Treating Patients With Recurrent Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Anaplastic Large Cell Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Mantle Cell Lymphoma
Interventions: DRUG: sorafenib tosylate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TEAM-Red, a Remotely Delivered Self-management Program for Depressed Black Women at Risk for Hypertension
Status: ACTIVE_NOT_RECRUITING
Conditions: Depression
Interventions: BEHAVIORAL: TEAM-Red|OTHER: Waitlist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Does Extraction Difficulty of Mandibular Impacted Third Molars Mirror Post-op Outcomes?
Status: RECRUITING
Conditions: Impacted Third Molar Tooth
Interventions: PROCEDURE: Extraction of impacted mandibular third molar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparing Pump With Subcutaneous Injection Delivery of PTH 1-34 in the Management of Chronic Hypoparathyroidism
Status: COMPLETED
Conditions: Hypoparathyroidism|Hypocalcemia
Interventions: DRUG: Synthetic Human Parathyroid Hormone 1-34
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study Between GR37547 500 Milligrams (mg) Tablet Versus Ciprofloxacin 500 mg Tablet Reference Product in Healthy Adult Subjects
Status: COMPLETED
Conditions: Infections, Bacterial
Interventions: DRUG: GR37547 tablet|DRUG: Ciprofloxacin reference tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Inflammatory Biomarkers and Postoperative Day 1 Drain Amylase Value Predict Pancreatic Fistula After Pancreaticoduodenectomy
Status: COMPLETED
Conditions: Pancreatic Fistula|Pancreas Cancer|Inflammatory Response
Interventions: PROCEDURE: Surgical Drain Management
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Mobile Neurofeedback for Adult Attention-Deficit/Hyperactivity Disorder (ADHD)
Status: UNKNOWN
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: Mobile Neurofeedback|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fasting Study of Levothyroxine Sodium Tablets 300 mcg to Synthroid® Tablets 300 mcg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LEVOTHYROXINE SODIUM TABLETS,|DRUG: SYNTHROID® 300 mcg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Acetylcysteine in Pediatric Acute Pyelonephritis.
Status: COMPLETED
Conditions: Pyelonephritis
Interventions: DRUG: Acetylcysteine|DRUG: placebo acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nitric Oxide Donors on Uterine and Subendometrial Blood Flow in Patients With Unexplained Infertility
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Infertility, Female
Interventions: DRUG: Nitroglycerin|DEVICE: Three dimensional power doppler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Genotyping for CYP450 Polymorphisms Versus Intense Clinical Monitoring on Antipsychotic Drug Treatment
Status: COMPLETED
Conditions: Schizophrenia
Interventions: GENETIC: (1) Genotyping for CYP4502D6 and 2C19 polymorphisms|OTHER: (2) Intense clinical monitoring|OTHER: (3) Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetics of Calcifediol and Cholecalciferol
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DIETARY_SUPPLEMENT: 25(OH)D3 (Calcifediol Hy.D) 10 mcg|DIETARY_SUPPLEMENT: 25(OH)D3 (Calcifediol Hy.D) 15 mcg|DIETARY_SUPPLEMENT: 25(OH)D3 (Calcifediol Hy.D) 20 mcg|DIETARY_SUPPLEMENT: Vitamin D3 (Cholecalciferol) 20 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Study to Evaluate Efficacy and Safety of Newrabell® Tab.(Rabeprazole Sodium) 10mg b.i.d in Refractory GERD
Status: COMPLETED
Conditions: Reflux Esophagitis
Interventions: DRUG: Newrabell® Tablet 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial Investigating Iloprost as Medication to Improve Bone Healing in Patients With Proximal Humeral Fracture
Status: RECRUITING
Conditions: Proximal Humeral Fracture
Interventions: DRUG: 0.125 ng/kg/min Iloprost|DRUG: 0.25 ng/kg/min Iloprost|PROCEDURE: open reduction and internal fixation with an angular stable plate (PHILOS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of an Intranasal SARS-CoV-2 Vaccine (BBV154) for COVID-19
Status: COMPLETED
Conditions: SARS-CoV Infection
Interventions: BIOLOGICAL: BBV154 Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Objective Evaluation of Ocular Surface Lubricants in Two Environments
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: B & L Soothe Lubricant Eye Drops|DRUG: Liposic EDO|DRUG: OcuFresh Eye Wash
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of Oxaliplatin and Gemcitabine With or Without Bevacizumab to Treat Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: oxaliplatin, gemcitabine, bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hepatic Arterial Infusion of Raltetrexed With Oxaliplatin(SALOX) Versus FOLFOX in Advanced Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: Raltitrexed, oxaliplatin (SALOX) treatment|PROCEDURE: Oxaliplatin, fluorouracil/leucovorin (FOLFOX) treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile App for Symptoms Monitoring in Cancer Patients: a Pilot Study
Status: UNKNOWN
Conditions: Cancer|Symptoms and Signs|Quality of Life|Chemotherapeutic Agent Toxicity
Interventions: DEVICE: Mentora app
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Sitagliptin on Hypertension, Arterial Stiffness, Oxidative Stress and Inflammation
Status: UNKNOWN
Conditions: Diabetes Mellitus|Arterial Stiffness
Interventions: DRUG: sitagliptin|DRUG: glibenclamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Biocomparison Study
Status: COMPLETED
Conditions: Bone Health|Vascular Health
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Vitamin K1-capsules|DIETARY_SUPPLEMENT: Vitamin K2-capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunoinflammatory Regulation of Esketamine in Septic Patients
Status: RECRUITING
Conditions: Esketamine|Sepsis|Inflammatory Response|Immunosuppression
Interventions: DRUG: Esketamine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-Tumoral Injections of Natural Killer Cells for Recurrent Malignant Pediatric Brain Tumors
Status: RECRUITING
Conditions: Pediatric Brain Tumor|Recurrent Pediatric Brain Tumor|Pediatric Supratentorial Neoplasm
Interventions: BIOLOGICAL: Universal Donor (UD) Transforming growth factor beta imprinting (TGFβi) Natural Killer (NK) Cells|PROCEDURE: Implantation|PROCEDURE: Magnetic Resonance Imaging (MRI)|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retention of a Flowable Resin-based Sealant With Two Types of Adhesives
Status: UNKNOWN
Conditions: Caries,Dental|Pit and Fissure Caries|Sealant Dental
Interventions: DEVICE: Scotchbond Universal 3M|DEVICE: Single Bond 3M
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Capsule Endoscopy for Post-Ablation Esophageal Lesion Assessment
Status: COMPLETED
Conditions: Esophageal Lesion
Interventions: DIAGNOSTIC_TEST: PillCam ESO Capsule Endoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Analysis of the Quality of Life, the Clinical Effectiveness and Cost-effectiveness of a Novel Educational Programme in Patients With Psoriasis and Atopic Dermatitis
Status: COMPLETED
Conditions: Psoriasis|Atopic Dermatitis
Interventions: BEHAVIORAL: education on skin disease conditions|BEHAVIORAL: Stress-reduction techniques|BEHAVIORAL: Lifestyle factors and psycho-education|OTHER: no educational program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Limonene on Regulating Metabolism-related Fatty Liver Disease (MAFLD) and Analysis of TCM Constitution
Status: COMPLETED
Conditions: Fatty Liver
Interventions: DRUG: Limonene capsule|DRUG: Limonene capsules(Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SBRT +/- Pembrolizumab in Patients With Local-Regionally Recurrent or Second Primary Head and Neck Carcinoma
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma (HNSCC)
Interventions: DRUG: Pembrolizumab|RADIATION: Stereotactic Body Radiation Therapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Plus Peripheral Stem Cell Transplant in Treating Patients With Central Nervous System Cancer
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Head and Neck Cancer|Lymphoma
Interventions: BIOLOGICAL: filgrastim|DRUG: carmustine|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: thiotepa|PROCEDURE: adjuvant therapy|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Androgen Receptor Directed Therapy on Cognitive Function in Patients Treated With Darolutamide or Enzalutamide
Status: RECRUITING
Conditions: Metastatic Prostate Cancer|Prostate Cancer Metastatic|Prostate Cancer|Castrate Resistant Prostate Cancer|Hormone Sensitive Prostate Cancer|Non-metastatic Prostate Cancer
Interventions: DRUG: Darolutamide|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Evaluation of Giomer and Resin-based Fissure Sealants
Status: COMPLETED
Conditions: Molar Incisor Hypomineralization
Interventions: DEVICE: Resin-based sealant|DEVICE: Giomer sealants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dietary Supplements and Aging Muscle
Status: COMPLETED
Conditions: Sarcopenia
Interventions: DIETARY_SUPPLEMENT: Juven|DIETARY_SUPPLEMENT: Juven
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Alkmaar MLPTI Cohort Study: Outcomes at 9 Years
Status: ENROLLING_BY_INVITATION
Conditions: Preterm Birth|Developmental Delay|Growth Delay
Interventions: DIAGNOSTIC_TEST: CBCL|DIAGNOSTIC_TEST: SDQ|DIAGNOSTIC_TEST: CCC-2-NL|DIAGNOSTIC_TEST: MCH Feeding scale|DIAGNOSTIC_TEST: TRF|DIAGNOSTIC_TEST: WISC-5-NL|DIAGNOSTIC_TEST: Movement ABC|DIAGNOSTIC_TEST: CELF-5-NL|DIAGNOSTIC_TEST: Emma Toolbox
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy Study of LUM001 (Maralixibat) With a Drug Withdrawal Period in Participants With Alagille Syndrome (ALGS)
Status: COMPLETED
Conditions: Alagille Syndrome
Interventions: DRUG: LUM001 (Maralixibat)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of PJ vs. Sugar on Glucose Levels in Healthy and Prediabetic Subjects
Status: COMPLETED
Conditions: Diabete Type 2|Pre Diabetes
Interventions: OTHER: PomJuice|OTHER: Water|OTHER: Sugar Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics, Biodistribution, Radiation Dose and Safety Study of 68Ga-NYM005 in Patients
Status: RECRUITING
Conditions: Clear Cell Renal Cell Carcinoma Metastatic
Interventions: DRUG: 68Ga-NYM005 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Impact of the Distribution of Adipose Tissue on the Occurrence of Metabolic Disorders and the Level of Cardiopulmonary Fitness
Status: COMPLETED
Conditions: Obesity, Abdominal
Interventions: DIAGNOSTIC_TEST: body composition analysis|OTHER: anthropometric measurements|OTHER: Interview questionnaire|DIAGNOSTIC_TEST: biochemical parameters|DIAGNOSTIC_TEST: cardiopulmonary fitness test|OTHER: nutritional interview
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of RNS60 on ALS Biomarkers
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: RNS60
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Soluble VE-cadherin in Prediction and Diagnosis of Early Postoperative Hypoxemia After Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Hypoxemia|ARDS|Lung Injury, Acute|Cardiopulmonary Bypass
Interventions: DIAGNOSTIC_TEST: blood cell analysis, blood gas surveillance, chest radiograph and echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Abdominal Drainage, Postoperative Antibiotico-prophylaxis and CME With D3 Lyphadenectomy Effect on Gastrointestinal Function in Laparoscopic Right Hemicolectomy With Intracorporeal Anastomosis for Right Colon Cancer
Status: COMPLETED
Conditions: Colon Cancer
Interventions: PROCEDURE: abdominal drainage|DRUG: Postoperative antibiotico-prophylaxis|PROCEDURE: Laparoscopic radical right colectomy with CME and D3 lymphadenectomy (RRC)|PROCEDURE: Laparoscopic standard D2 right hemicolectomy (STANDARD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab as Neoadjuvant Therapy for Resectable Stage IA3 to IIA Non-Small Cell Lung Cancer (NSCLC)
Status: RECRUITING
Conditions: Lung Cancer, Nonsmall Cell
Interventions: DRUG: Pembrolizumab|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Drug-drug Interaction Study Between RaltEgravir and CITALopram in Healthy Subjects (RECITAL).
Status: COMPLETED
Conditions: HIV|Depression
Interventions: DRUG: raltegravir|DRUG: citalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Mifepristone Plus Misoprostol Versus Misoprostol Alone for 2nd Trimester Abortion (14 - 21 Weeks Last Menstrual Period (LMP))
Status: COMPLETED
Conditions: Abortion, Induced
Interventions: DRUG: mifepristone+misoprostol|DRUG: misoprostol+placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Study Comparing Brand and Generic Immunosuppression on Transplant Outcomes, Adherence, & Immune Response in Kidney Transplant Recipients
Status: COMPLETED
Conditions: Renal Transplant Rejection
Interventions: DRUG: Prograf|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial for the Treatment of Relapsed Osteosarcoma
Status: TERMINATED
Conditions: OSTEOSARCOMA
Interventions: DRUG: Gemcitabine and Docetaxel|DRUG: Ifosfamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ischia Spinous Fascia Fixation Procedure Versus Modified Total Pelvic Floor Reconstructive Surgery for Pelvic Organ Prolapse Stage III
Status: UNKNOWN
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: ischia spinous fascia fixation|PROCEDURE: Modified Pelvic Floor Reconstruction Surgery with Mesh|DEVICE: polypropylene mesh(Gynemesh)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Noise on Anesthesiologists' and Trainees' Situational Awareness in a High Fidelity Simulation Environment
Status: COMPLETED
Conditions: Noise; Adverse Effect
Interventions: OTHER: Exposition to high-dB soundtrack
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Diplegic Cerebral Palsy and Action Observation Training
Status: COMPLETED
Conditions: Diplegic Cerebral Palsy
Interventions: OTHER: Video Based Action Observation|OTHER: Live Action Observation|OTHER: Conventional physiotherapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Skills Training Using Computer for Patients With Severe Mental Illness
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: BEHAVIORAL: Computerized Cognitive Skill Training|BEHAVIORAL: CRT and Social Cognition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vancomycin in Primary Sclerosing Cholangitis in Italy
Status: RECRUITING
Conditions: Primary Sclerosing Cholangitis|Liver and Intrahepatic Bile Duct Disorder|IBD
Interventions: DRUG: Oral Vancomycin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cyclophosphamide and Busulfan as Conditioning Regimen Before Allogeneic HSCT
Status: COMPLETED
Conditions: Myeloid Leukemia|Precursor Myeloid Neoplasms|Lymphoid Neoplasms
Interventions: DRUG: Busulfan-Cyclophosphamide as Conditioning Regimen before Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Cyclophosphamide-Busulfan as Conditioning Regimen before Allogeneic Hematopoietic Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Anti-Reflux Procedures in Neurologically Impaired Children
Status: COMPLETED
Conditions: Gastroesophageal Reflux|Nervous System Diseases|Fundoplication|Enteral Nutrition
Interventions: PROCEDURE: Fundoplication|PROCEDURE: Gastrojejunal (GJ) feeding tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RPTR-147 in Patients With Selected Solid Tumors and Lymphomas
Status: TERMINATED
Conditions: Solid Tumor|Lymphoma
Interventions: BIOLOGICAL: Arm A: RPTR-147:1|BIOLOGICAL: Arm B: RPTR-147:1 and Pembrolizumab|BIOLOGICAL: Arm C: RPTR-147:2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Study the Effects of Mango Ingestion in T2DM and Non-diabetic Subjects.
Status: COMPLETED
Conditions: Normoglycemia|T2DM (Type 2 Diabetes Mellitus)
Interventions: DIETARY_SUPPLEMENT: Bread|DIETARY_SUPPLEMENT: Mango
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Extension Study to Evaluate the Long-Term Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD)
Status: ENROLLING_BY_INVITATION
Conditions: Huntington Disease
Interventions: DRUG: PTC518
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous CMV-Specific Cytotoxic T Cells and Temozolomide in Treating Patients With Glioblastoma
Status: COMPLETED
Conditions: Cytomegalovirus Positive|Glioblastoma|Gliosarcoma|Malignant Glioma|Recurrent Brain Neoplasm|Recurrent Glioblastoma
Interventions: BIOLOGICAL: Autologous Cytomegalovirus-specific Cytotoxic T-lymphocytes|OTHER: Laboratory Biomarker Analysis|DRUG: Temozolomide|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Staphylococcus Aureus and The Skin Microbiome During Flare And Resolution Of Atopic Dermatitis
Status: RECRUITING
Conditions: Atopic Dermatitis|Atopic Dermatitis Eczema|Atopic Dermatitis Flare
Interventions: DRUG: Dicloxacillin Oral Capsule|DRUG: Elocon 0.1 % Topical Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Desmopressin Orally Disintegrating Tablets (ODT) for Nocturia Due to Nocturnal Polyuria in Japanese Female Subjects
Status: COMPLETED
Conditions: Nocturia
Interventions: DRUG: Desmopressin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment for Executive Dysfunction in Adult Survivors of Childhood Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DEVICE: transcranial Direct Current Stimulation (tDCS)|DEVICE: Sham|OTHER: Cognitive Assessment|OTHER: Brain Games Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Analgesia in Pediatric Hypospadias Surgeries
Status: NOT_YET_RECRUITING
Conditions: Hypospadias
Interventions: PROCEDURE: US guided caudal block|PROCEDURE: Dorsal penile nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of SFA002 in Patients With Mild to Moderate Psoriasis Plaques
Status: RECRUITING
Conditions: Psoriasis
Interventions: DRUG: Drug (SFA002) Vitamin D, Magnesium|DRUG: Drug (SFA002) Vitamin D, Magnesium and Propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT