pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of K-757 in Healthy Overweight/Obese Volunteers
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: K-757|DRUG: K-757 and open-label sitagliptin|DRUG: Matching placebo to K-757|DRUG: Matching placebo to K-757 and matching placebo to K-833|DRUG: K-757 and K-833|DRUG: Matching placebo to K-757, open-label sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Levobupivacaine to the Surgical Wound Following Cesarean
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Levobupivacaine|DRUG: NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Nimotuzumab Combined With Concurrent Chemoradiotherapy for Locally Advanced Cervical Cancer
Status: UNKNOWN
Conditions: Neoplasms|Cervical Adenosquamous Cell Carcinoma|Cervical Squamous Cell Carcinoma in Situ|Stage IB Cervical Cancer|Stage IIA Cervical Cancer|Stage IIB Cervical Cancer|Stage III Cervical Cancer|Stage IVA Cervical Cancer
Interventions: DRUG: Nimotuzumab|DRUG: Cisplatin|RADIATION: external-beam radiation|RADIATION: brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Radiation Therapy vs. Microwave Ablation for Colorectal Cancer Patients With Metastatic Disease in the Liver
Status: RECRUITING
Conditions: Colorectal Carcinoma|Liver Metastases
Interventions: DEVICE: MWA|RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of HR011408 and NovoRapid® in Subjects With Diabetics
Status: RECRUITING
Conditions: Diabetes
Interventions: DRUG: HR011408 injection; HR011408 injection Placebo|DRUG: NovoRapid®; HR011408 injection Placebo|DRUG: HR011408 injection Placebo; HR011408 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: URO-902 in Female Subjects With Overactive Bladder and Urge Urinary Incontinence
Status: COMPLETED
Conditions: Overactive Bladder With Urge Urinary Incontinence
Interventions: DRUG: URO-902|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Rome Trial From Histology to Target: the Road to Personalize Target Therapy and Immunotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Gastrointestinal Cancer|Non Small Cell Lung Cancer|Other Cancer
Interventions: DRUG: Erlotinib|DRUG: Trastuzumab|DRUG: Trastuzumab emtansine|DRUG: Pertuzumab|DRUG: Lapatinib|DRUG: Everolimus|DRUG: Vemurafenib|DRUG: Cobimetinib|DRUG: Alectinib|DRUG: Brigatinib|DRUG: Palbociclib|DRUG: Ponatinib|DRUG: Vismogedib|DRUG: Itacitinib|DRUG: Ipatasertib|DRUG: Entrectinib|DRUG: Atezolizumab|DRUG: Nivolumab|DRUG: Ipilimumab|DRUG: Pemigatinib|DRUG: Oncology Drugs|DRUG: Pralsetinib|DRUG: Selpercatinib|DRUG: Talazoparib|DRUG: Tepotinib|DRUG: Alpelisib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Possibilities in Ophthalmological Diseases Using Swept Source Optical Coherence Tomography
Status: RECRUITING
Conditions: Retinal Disease|Diabetic Retinopathy|Macular Degeneration
Interventions: DIAGNOSTIC_TEST: SS-OCT system Plex Elite 9000
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Time-restricted Eating and Aerobic Exercise Training in Women With Overweight and Obesity
Status: NOT_YET_RECRUITING
Conditions: Time Restricted Eating|Obesity|Intermittent Fasting|Overweight and Obesity|Time Restricted Feeding
Interventions: BEHAVIORAL: Dietary and Exercise Approaches|BEHAVIORAL: Dietary and Exercise Approaches|BEHAVIORAL: Dietary Approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mother Milk as a Eye Drop & Premature Retinopathy
Status: COMPLETED
Conditions: Retinopathy of Prematurity
Interventions: DRUG: Normal Saline|BIOLOGICAL: Breast milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intravitreal Bevacizumab for Neovascular Glaucoma
Status: COMPLETED
Conditions: Neovascular|Glaucoma
Interventions: OTHER: subconjunctival normal saline|DRUG: Avastin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Nokyong Mixture Extract(CME-PI) on Promotion of Immunity
Status: COMPLETED
Conditions: Immunity
Interventions: DIETARY_SUPPLEMENT: Nokyong Mixture Extract(CME-PI)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pizza Leavening and Postprandial Glycemia in Type 1 Diabetes (LEAVEN)
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: OTHER: LONG LEAVENING|OTHER: SHORT LEAVENING|OTHER: TRADITIONAL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Optical Spectral Imaging System for Imaging Breast Tumor Margins
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DEVICE: miniature spectral imaging system|DEVICE: Bench-top optical spectrometer|DEVICE: High resolution microendoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Niraparib Versus Niraparib-bevacizumab Combination in Women With Platinum-sensitive Epithelial Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Niraparib|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of PRT543 in Participants With Advanced Solid Tumors and Hematologic Malignancies
Status: COMPLETED
Conditions: Relapsed/Refractory Advanced Solid Tumors|Relapsed/Refractory Diffuse Large B-cell Lymphoma|Relapsed/Refractory Myelodysplasia|Relapsed/Refractory Myelofibrosis|Adenoid Cystic Carcinoma|Relapsed/Refractory Mantle Cell Lymphoma|Relapsed/Refractory Acute Myeloid Leukemia|Refractory Chronic Myelomonocytic Leukemia
Interventions: DRUG: PRT543
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Co-Bedding as a Comfort Measure for Twins Undergoing Painful Procedures
Status: COMPLETED
Conditions: Neonatal Procedural Pain Response
Interventions: PROCEDURE: Co-bedding (caring for twins in the same incubator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dermaprazole Cream for Radiation Dermatitis in Head and Neck Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer of the Head and Neck
Interventions: DRUG: Dermaprazole|DRUG: Aquaphor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Randomised Study of Preoperative Radiotherapy With Consolidating Chemotherapy for Unresectable Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: RADIATION: Short course of radiotherapy|RADIATION: Radiochemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Dietary Supplementation With Omega-3 Fatty Acids on Symptoms of Dry Eye
Status: COMPLETED
Conditions: Dry Eye
Interventions: DIETARY_SUPPLEMENT: Supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Antiplatelet Therapy for Intracranial Aneurysm Stent-assisted Coiling
Status: UNKNOWN
Conditions: Embolic Stroke
Interventions: DRUG: Aspirin and clopidogrel|DRUG: Aspirin and clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prehabilitation - Enhanced Recovery After Colorectal Surgery
Status: COMPLETED
Conditions: Surgical Operation With Reversal of External Stoma|Colorectal Surgery
Interventions: OTHER: Cardiorespiratory and resistance training.|OTHER: Reference
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Determine the Efficacy of Topical Tretinoin Cream for the Prevention of Nonmelanoma Skin Cancer
Status: COMPLETED
Conditions: Carcinoma, Basal Cell|Carcinoma, Squamous Cell|Skin Neoplasms
Interventions: DRUG: Tretinoin 0.1% cream or placebo|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic BM-MSCs in Patients With Lumbar Facet Arthropathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Facet-Mediated Low Back Pain
Interventions: DRUG: Single bilateral intra-articular injection of allogeneic BM-MSCs for lumbar facet joint arthropathy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: At-Home Diaphragmatic Interventions for Voiding Abnormalities (DIVA)
Status: COMPLETED
Conditions: Dysfunctional Voiding|Urinary Dysfunction
Interventions: BEHAVIORAL: Diaphragmatic Breathing Exercises|BEHAVIORAL: Bladder Hygiene Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Exploratory Efficacy of Transplantation Therapy Using PSA-NCAM(+) NPC in AIS-A Level of Sub-acute SCI
Status: RECRUITING
Conditions: Spinal Cord Injury, Acute|Spinal Cord Injury at C4 Level With Complete Lesion|Spinal Cord Injury at C5-C7 Level With Complete Lesion
Interventions: BIOLOGICAL: Neural precursor cells derived from human embryonic stem cell line
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can VI-RADS/ADC Accurately Stage Bladder Cancer??
Status: ACTIVE_NOT_RECRUITING
Conditions: MRI Contrast Media Adverse Reaction|Bladder Cancer|Bladder Disease|Bladder Neoplasm|Bladder Urothelial Carcinoma|Bladder Cancer Stage|Diagnoses Disease
Interventions: RADIATION: Multi-parametric MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase II Clinical Study to Evaluate the Efficacy of Multidose Lagricel® Ofteno Ophthalmic Solution as Treatment for Dry Eye Disease.
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Sodium Hyaluronate Ophthalmic 0.4% BID|DRUG: Sodium Hyaluronate Ophthalmic 0.4% QID|DRUG: Sodium Hyaluronate Ophthalmic 0.4% Six times per day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Statins for Oxidative Stress and Mitochondrial Function in Diabetic Polyneuropathy
Status: COMPLETED
Conditions: Oxidative Stress|Diabetic Polyneuropathy
Interventions: DRUG: calcined magnesia|DRUG: Ezetimibe/simvastatin|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of e-Cigarettes on Perceptions and Behavior - Substudy 1
Status: COMPLETED
Conditions: Electronic Cigarette Use|Cigarette Use, Electronic|Vaping|Cigarette Smoking
Interventions: DRUG: E-cigarette e-liquid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of the Regeneration Capacity of Satellite Cells From the Quadriceps Compared to That of the Diaphragm
Status: COMPLETED
Conditions: Diaphragm Injury|Mechanical Ventilation Complication
Interventions: OTHER: Quadriceps microbiopsy using a Tru-Cut biopsy needle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety, Tolerability and Maximum Tolerated Dose of Oral AP23573 in Combination With Doxorubicin (8669-015)
Status: COMPLETED
Conditions: Cancer|Sarcoma
Interventions: DRUG: ridaforolimus|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atomoxetine as an Adjunct to Novel Antipsychotic Medication in the Treatment of Cognitive Deficits of Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Atomoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Drug-Drug Interaction Study of FDL169 and FDL176 in Healthy Subjects
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: FDL176 & FDL169 coadministration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Safety, Tolerability and Pharmacokinetics of PMZ-2010 (Centhaquin) in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PMZ-2010 (Centhaquin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate LTI-01 in Patients With Infected, Non-draining Pleural Effusions
Status: COMPLETED
Conditions: Pleural Effusion
Interventions: DRUG: LTI-01|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: REC2Stim as a Treatment for Refractory Epilepsy in the Primary Sensorimotor Cortex.
Status: UNKNOWN
Conditions: Epileptic Seizure|Epilepsy Intractable|Motor Seizure
Interventions: DEVICE: ECoG sensing and stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Music Added to the Usual Treatment on the Anxiety of Patients Undergoing Outpatient Cataract Surgery With Topical Anesthesia
Status: RECRUITING
Conditions: Cataract Surgery|Anxiety
Interventions: DEVICE: MusicCare® device|DEVICE: Device with quiet recorded music|OTHER: Usual management of anxiety
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Determine Pharmacokinetics of Children Receiving Modigraf (Tacrolimus Granules) Following Solid Organ Transplantation
Status: COMPLETED
Conditions: Kidney Transplantation|Heart Transplantation|Liver Transplantation
Interventions: DRUG: Tacrolimus granules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Phantom Limb Pain Using Peripheral Nerve and Spinal Cord Stimulation
Status: ENROLLING_BY_INVITATION
Conditions: Phantom Limb Pain|Phantom Pain|Amputation
Interventions: PROCEDURE: Implantation of PNS electrodes during surgery, mapping to select sites with the best effect and pain modulation.|PROCEDURE: SCS electrode implantation at surgery, mapping to select sites with the best effect and pain modulation.|PROCEDURE: EEG to search for phantom pain biomarkers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Auricular Press Needle on Visual Analogue Scale (VAS) and Short Form (SF-12) Scores in Chronic Pain With Depression Symptoms
Status: NOT_YET_RECRUITING
Conditions: Chronic Pain|Depressive Symptoms
Interventions: DEVICE: Press Needle|DEVICE: Sham Press Needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Panobinostat, Etoposide, and Cisplatin as First-Line Therapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: etoposide phosphate|DRUG: panobinostat|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: H9 Priming Study in Healthy Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Subvirion inactivated influenza A/H9N2 (G9 variant) vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Radiation Therapy in Preventing Metastatic Cancer in Patients Who Have Diagnostic Procedures to Identify Malignant Mesothelioma
Status: COMPLETED
Conditions: Malignant Mesothelioma|Perioperative/Postoperative Complications
Interventions: PROCEDURE: quality-of-life assessment|PROCEDURE: standard follow-up care|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Ultra-hypofractionated for Whole Breast Irradiation (WBI) Compared to Partial Breast Irradiation (PBI)
Status: RECRUITING
Conditions: Breast Cancer Female
Interventions: RADIATION: Ultra-fractionated WBI|RADIATION: Ultra-fractionated PBI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EUS Shear Wave for Solid Pancreatic Lesions.
Status: UNKNOWN
Conditions: Pancreas Neoplasm|Pancreatitis|Pancreatitis, Acute|Pancreatitis, Chronic|Pancreatitis, Autoimmune
Interventions: DIAGNOSTIC_TEST: Pancreas EUS shear wave|DIAGNOSTIC_TEST: Pancreas EUS-elastography and EUS-guided biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prevention of Childhood Anxiety Disorders in Offspring of Anxious Parents
Status: ACTIVE_NOT_RECRUITING
Conditions: Anxiety Disorders
Interventions: BEHAVIORAL: Confident Parents - Brave Children (CPBT)|BEHAVIORAL: Self-help book "What all parents ought to know"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Artesunate Plus Standard of Care in Active Lupus Nephritis
Status: UNKNOWN
Conditions: Lupus Nephritis
Interventions: DRUG: Artesunate|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemoimmunotherapy Followed By Radiation Or Organ Preservation Surgery In Laryngeal/Hypopharyngeal Cancer
Status: RECRUITING
Conditions: Larynx Cancer|Hypopharyngeal Cancer
Interventions: PROCEDURE: Surgery|RADIATION: Radiation|DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Adding Magnesium Sulphate in Pericapsular Nerve Group Block
Status: NOT_YET_RECRUITING
Conditions: Hip Fractures
Interventions: DRUG: Pericapsular nerve group block using bupivicaine and magnesium sulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Daily Dietary Intake of Dried Juice Concentrates of Fruit, Vegetables and Berries Upon Outcomes of Chronic Periodontitis
Status: COMPLETED
Conditions: Periodontitis
Interventions: DIETARY_SUPPLEMENT: Juice plus+|DIETARY_SUPPLEMENT: Placebo non active capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterisation of the Immune Responses of 2 Experimental Malaria Vaccines
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: GSK Malaria vaccine 257049
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Comparison of the Endovascular and the Hybrid Methods for the Treatment of Prolonged Atherosclerotic Lesions of the Femoral-popliteal Segment Above the Knee, TASC II, Type D
Status: UNKNOWN
Conditions: Atherosclerosis|Ischemia Limb|Superficial Femoral Artery Occlusion|Popliteal Artery Occlusion|Stent Complication
Interventions: PROCEDURE: recanalization of the femoral-popliteal arterial segment above the knee with angioplasty and stenting with a biomimetic interwoven nitinol stent, supplemented by fasciotomy in Hunter's canal.|PROCEDURE: recanalization of the femoral-popliteal arterial segment above the knee with angioplasty and stenting with a biomimetic interwoven nitinol stent.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two-cohort Study of Toripalimab(PD1)+Lenvatnib, or Gemox+Lenvatinib in Advanced Intrahepatic Cholangiocarcinoma
Status: UNKNOWN
Conditions: Cholangiocarcinoma, Intrahepatic
Interventions: DRUG: Lenvatinib combined with gemox|DRUG: Toripalimab combined with lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Immunogenicity and Safety of Concomitant Administration of Novel Oral Polio Type 2 Vaccine and Bivalent Oral Polio Vaccine
Status: WITHDRAWN
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: bOPV and nOPV2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Intraosseous Doppler Ultrasonography to Study Skeletal Physiology: Exploratory Study Before Use in Space Physiology
Status: NOT_YET_RECRUITING
Conditions: Healthy Volunteers
Interventions: DEVICE: Intraosseous ultrasonography at tibia before, during, and after a physiological vascular stimulation (venous occlusions, arterial occlusion, handgrip)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prospective Evaluation of Clinical and Radiographic Outcomes Following Total Talus Replacement (PROCLAIM)
Status: NOT_YET_RECRUITING
Conditions: Avascular Necrosis of the Talus|Talar Osteochondral Defect of Ankle|Talar Dysfunction
Interventions: DEVICE: Total Talus Replacement (TTR)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Biodegradable Pancreatic Stents for the Prevention of Postoperative Pancreatic Fistula After Cephalic Pancreaticoduodenectomy
Status: UNKNOWN
Conditions: Pancreatic Fistula|Pancreas Neoplasm|Stent Disintegration|Pancreatic Cancer|Pancreatic Anastomotic Leak
Interventions: DEVICE: Biodegradable stent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Locally Delivered Tea Tree Oil Gel as an Adjunct to Non-Surgical Periodontal Management
Status: COMPLETED
Conditions: Periodontal Pocket
Interventions: DRUG: Melaleuca Alternifolia Oil|PROCEDURE: Non-surgical periodontal debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: GLP-1 Receptor Agonist Lixisenatide Versus Exenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Lixisenatide (AVE0010)|DEVICE: Pen auto-injector|DRUG: Exenatide|DEVICE: Prefilled pen injector|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Propranolol for Prevention of Threshold Retinopathy of Prematurity
Status: RECRUITING
Conditions: Retinopathy of Prematurity
Interventions: DRUG: Propranolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Comparison of Visualization Between Shamrock Technique and Paramedian Transverse Scan in Lumbar Plexus Blockade
Status: COMPLETED
Conditions: Lumbar Plexus Blockade
Interventions: PROCEDURE: shamrock|PROCEDURE: paramedian transverse scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase I Trial of Inhaled Nitric Oxide to Treat Acute Pulmonary Embolism
Status: COMPLETED
Conditions: Pulmonary Embolism
Interventions: DRUG: nitric oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Different Ratio of Ketofol (6:1 vs. 4:1) for Sedation in Endoscopic Retrograde Cholangiopancreatography (ERCP)
Status: COMPLETED
Conditions: Analgesia
Interventions: DRUG: Propofol and Ketamine Mixture (Ketofol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Middle East Dual Anti-platelet Treatment in Acute Transient Ischemic Attack
Status: WITHDRAWN
Conditions: Transient Ischemic Attacks|Minor Stroke
Interventions: DRUG: anti-thrombotic treatment using Aspirin (ASA 75-325mg) and Clopidogrel (75mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Called AWARENESS Using Data From Men in Alberta to Observe Treatment Patterns for Metastatic Castration-sensitive Prostate Cancer
Status: COMPLETED
Conditions: Metastatic Castration-sensitive Prostate Cancer
Interventions: DRUG: ADT (Eligard®*) with or without treatment intensification
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MRI-Guided Stereotactic Body Radiation Therapy (SBRT) for Ovarian Cancer
Status: COMPLETED
Conditions: Cancer of Ovary|Cancer of the Ovary|Neoplasms, Ovarian|Ovarian Cancer|Ovary Cancer|Ovary Neoplasms
Interventions: DEVICE: MRI-guided SBRT|BEHAVIORAL: EORTC QLQ-C30 Questionnaire|BEHAVIORAL: EORTC QLQ-OV28 Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Lenalidomide and Markers for Disease Progression in Patients With International Prognostic Scoring System (IPSS) Low- or Intermediate-1 Risk Myelodysplastic Syndromes (MDS) With Isolated del5q
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Agonist Contract Relax Versus Antagonist Contract Relax in Chronic Stroke Patient.
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Routine physical therapy|OTHER: antagonist contract relax|OTHER: agonist contract relax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Withdrawal Symptoms and Prevention of Relapse in Patients With Tramadol Abuse
Status: COMPLETED
Conditions: Opiate Withdrawal Syndrome
Interventions: DRUG: Venlafaxine|DRUG: Lofexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Robot-enhanced Therapy for Children With Autism Spectrum Disorders
Status: COMPLETED
Conditions: Autistic Disorders Spectrum
Interventions: BEHAVIORAL: (2) robot--enhanced intervention|BEHAVIORAL: (1) discrete trial training / cognitive-behavior therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Control Trial of Group Intervention With Former War-affected Boys in the Democratic Republic of Congo
Status: COMPLETED
Conditions: Post-traumatic Stress Disorder|Depression|Conduct Disorder
Interventions: BEHAVIORAL: TF-CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extracellular Vesicles as Biomarkers for Chronic Renal Failure
Status: COMPLETED
Conditions: Chronic Renal Failure|Urinary Extracellular Vesicle
Interventions: DIAGNOSTIC_TEST: urinary extracellular vesicle concentration|DIAGNOSTIC_TEST: blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 2/3 Oxabact Study
Status: COMPLETED
Conditions: Primary Hyperoxaluria
Interventions: BIOLOGICAL: Oxalobacter formigenes|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Remediation Therapy in Schizophrenia: Effects on BDNF Levels
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Cognitive Remediation Therapy|BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Interaction Between Vytorin and Niaspan in Healthy Subjects (P04955AM2)
Status: COMPLETED
Conditions: Hypercholesterolemia|Hyperlipidemia
Interventions: DRUG: Vytorin + Niaspan|DRUG: Vytorin|DRUG: Niaspan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of PoNS in Reducing Symptoms of Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DEVICE: Portable Neuromodulation Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dyad Plus Effectiveness
Status: RECRUITING
Conditions: Weight Loss|Pediatric Obesity|Overweight Adolescents|Parent-Child Relations|Family and Household
Interventions: BEHAVIORAL: Brenner FIT Standard|BEHAVIORAL: By Design Essentials|BEHAVIORAL: Dyad Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nadroparin Versus TIPS in Cirrhotic Patients With Refractory Asymptomatic PVT
Status: NOT_YET_RECRUITING
Conditions: Portal Vein Thrombosis
Interventions: PROCEDURE: TIPS|DRUG: Nadroparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Talimogene Laherparepvec Neoadjuvant Treatment Plus Surgery Versus Surgery Alone for Melanoma
Status: COMPLETED
Conditions: Completely Resectable Stage IIIB, IIIC, or IVM1a Melanoma
Interventions: DRUG: Talimogene Laherparepvec|PROCEDURE: Immediate surgical resection of melanoma lesion(s)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the "Milk Ladder" Intervention in the Development of Tolerance and the Recognition of B Cell Epitopes in Babies Who Are Allergic to Cow's Milk Proteins
Status: UNKNOWN
Conditions: IgE-mediated Milk Allergy
Interventions: OTHER: Milk
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Iovera®° in Adult Patients Undergoing Total Knee Arthroplasty
Status: TERMINATED
Conditions: Post-Operative Pain Management
Interventions: DEVICE: ioveraº|DEVICE: ioveraº sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Transdiagnostic Sleep and Circadian Treatment for Major Depressive Disorder
Status: UNKNOWN
Conditions: Major Depressive Disorder|Sleep Disturbance
Interventions: BEHAVIORAL: Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of Atezolizumab Administered in Combination With Bevacizumab and/or Other Treatments in Participants With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: 5-FU|DRUG: Atezolizumab|DRUG: Bevacizumab|DRUG: Gemcitabine|DRUG: Leucovorin|DRUG: Nab-Paclitaxel|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Open-label, Single-dosing, 2X2 Crossover Study to Compare the Safety and Pharmacokinetics of BR-TND Tablet(Tenofovir Disoproxil) With Viread Tablet(Tenofovir Disoproxil Fumarate) in Healthy Male Volunteers
Status: COMPLETED
Conditions: Hepatitis
Interventions: DRUG: Tenofovir disoproxil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive-Behavioral Therapy (CBT) in Children With Diabetes
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 1
Interventions: BEHAVIORAL: "CBT" (Cognitive-Behavioral Therapy)|BEHAVIORAL: Control (telephonic support without CBT content)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Fixed Dose Combination of Macitentan/Tadalafil (10 mg/20 mg) Compared to the Reference Free Combination of Macitentan and Tadalafil in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Macitentan 10 mg|DRUG: Tadalafil 20 mg|DRUG: Macitentan 10 mg/Tadalafil 20mg FDC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Canakinumab in the Treatment of Acute Gout Flares and Prevention of New Flares in Patients Unable to Use Non-steroidal Anti-inflammatory Drugs (NSAIDs) and/or Colchicines Including a 12 Week Extension and a 1 Year Open-label Extension Study.
Status: COMPLETED
Conditions: Acute Gout
Interventions: DRUG: Canakinumab 150 mg|DRUG: Triamcinolone acetonide 40 mg|DRUG: Placebo to canakinumab|DRUG: Placebo to triamcinolone acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Blue Light Filtering IOL
Status: COMPLETED
Conditions: to Compare the Effect of Two Types of IOLs|on the Incidence of Cystoid Macular Edema|After Cataract Surgery
Interventions: PROCEDURE: intraocular lens implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Oscillating Positive Expiratory Pressure Devices and Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Status: RECRUITING
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DEVICE: OPEP Aerobika|DEVICE: OPEP Aerobika Sham device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of Moxonidine and Diet on Sympathetic Functions in Young Adults With Obesity
Status: UNKNOWN
Conditions: Obesity|Overweight
Interventions: DRUG: Moxonidine (Physiotens)|OTHER: Dietary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Efficacy of Cold-FX (CVT-E002) in the Prevention of Upper Respiratory Tract Infections in Healthy Adults
Status: COMPLETED
Conditions: Upper Respiratory Infection
Interventions: DRUG: CVT-E002 (Cold-FX); a natural health product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Shave Margins vs. Standard Partial Mastectomy in Breast Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: PROCEDURE: Partial mastectomy plus additional Shave Margin|PROCEDURE: Partial mastectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing MENOPUR in a Pen Formulation With a Powder and Solvent Formulation in Healthy Women
Status: COMPLETED
Conditions: Infertility, Female
Interventions: DRUG: A MENOPUR solution for injection in pre-filled pen, 600 IU/0.96 mL|DRUG: A MENOPUR powder including solvent for solution for injection, 75 IU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn How Different Amounts of the Study Medicine Danuglipron Are Taken up Into the Blood in Otherwise Healthy Adults With Overweight or Obesity
Status: NOT_YET_RECRUITING
Conditions: Obesity
Interventions: DRUG: Danuglipron
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: NOPHO ALL-2008 Pilot Study on Consolidation Therapy for Children and Adolescents With Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Leukemia, Lymphocytic, Acute
Interventions: DRUG: 6-mercaptopurine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Zhuli Capsule on Phlegm-heat Syndrome (Tan-re Zheng)
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease|Chronic Bronchitis
Interventions: DRUG: Zhuli capsule|DRUG: Placebo|OTHER: Standard medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Digital Incentive Spirometer (DIS): Improving Adherence to Incentive Spirometry
Status: COMPLETED
Conditions: Post-Op Infection|Adherence, Patient|Pulmonary Atelectasis|Incentive Spirometry|Post-Op Complication
Interventions: BEHAVIORAL: Smartphone Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Evaluate Safety and Pharmacokinetics of Belinostat in Patients Who Have Mild, Moderate and Severe Renal Impairment.
Status: TERMINATED
Conditions: Relapsed/Refractory Solid Tumors/Hematological Malignancies
Interventions: DRUG: Belinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PhytoSERM for Menopausal Hot Flashes and Sustained Brain Health
Status: RECRUITING
Conditions: Menopause|Hot Flashes
Interventions: DIETARY_SUPPLEMENT: PhytoSERM|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Evacetrapib (LY2484595) and Warfarin in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Evacetrapib|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Monitoring of Cerebral and Abdominal Tissue Oxygen Saturation in Neonates
Status: UNKNOWN
Conditions: Establish the Incidence Rate of Abdominal and Cerebral Hyperoxemia and Hypoxemia Events in Neonates at Birth
Interventions: DEVICE: NIRS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Parental Support on Pregnancy Outcomes (IPSO) Trial- Day 3 Preimplantation Genetic Screening (PGS) With Day 5 Fresh Transfer
Status: TERMINATED
Conditions: Preimplantation Gentic Screening (PGS)|In Vitro Fertilization (IVF)|Preimplantation Genetic Diagnosis (PGD)
Interventions: DEVICE: 24 Chromosome Aneuploidy Screening with Parental Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Development of Imaging Biomarkers for Voice After Pediatric Airway Reconstruction
Status: TERMINATED
Conditions: Voice Disorders
Interventions: PROCEDURE: Microlaryngoscopy|PROCEDURE: Voice Evaluation|PROCEDURE: Airway Reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Single-Dose Escalation Study of IDX184 in Healthy Volunteers (MK-2355-002)
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: IDX184|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Satisfaction/Quality of Life With Rivaroxaban in SPAF (Stroke Prevention in Atrial Fibrillation) Indication
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Prospective, Open Label, Non Randomized, Clinical Study to Evaluate the Safety and Effectiveness of the Eraser Tattoo Removal Device
Status: UNKNOWN
Conditions: Removal of Colors Tattoo (Multiple Colors)
Interventions: DEVICE: Eraser device+ salicylic acid (5%)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Clinical Trial for Children With TCRαβ Depleted vs Traditional Haplo Identicle HSCT
Status: RECRUITING
Conditions: Graft-Versus-Host Disease|Hematopoietic Stem Cell Transplantation|Child, Only|Haploidentical Hematopoietic Stem Cell Transplantation
Interventions: PROCEDURE: TCRαβ Depleted haploidentical HCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interactive Mobile Health Information to Enhance Patient Care at a Cystic Fibrosis Center
Status: COMPLETED
Conditions: Medication Adherence|Cystic Fibrosis
Interventions: DEVICE: caremessage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Upper Extremity Rehabilitation Using SMART Glove System With Transcranial Direct Current Stimulation
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: SMART Glove system with tDCS|DEVICE: SMART Glove system with sham-tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Uncontrolled Hypertension Management Among Jordanian Adults
Status: RECRUITING
Conditions: Hypertension|Physical Activity|Dietary Habits|Medication Adherence|Motivational Interviewing
Interventions: BEHAVIORAL: DASH-ExMAMI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Extragonadal Germ Cell Tumor|Ovarian Cancer|Teratoma|Testicular Germ Cell Tumor
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: etoposide|DRUG: ifosfamide|DRUG: paclitaxel|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: bone marrow ablation with stem cell support
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HighCycle Study: Effect of Acetazolamide on Sleep Disordered Breathing in Women Compared to Men
Status: RECRUITING
Conditions: Sleep-Disordered Breathing
Interventions: DRUG: Acetazolamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sanofi 2017 H7N9 With/Without AS03 in Adults/Elderly
Status: COMPLETED
Conditions: Avian Influenza|Influenza Immunisation
Interventions: DRUG: AS03|BIOLOGICAL: Inactivated influenza H7N9 vaccine|OTHER: Phosphate Buffered Saline (PBS) diluent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Home Automated Telemanagement in Chronic Obstructive Pulmonary Disorder
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: BEHAVIORAL: Home Automated Telemanagement (HAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH