pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: REirradiation and Programmed Cell Death Protein 1 (PD-1) Blockade On Recurrent Squamous Cell Head and Neck Tumors
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Nivolumab|RADIATION: Radiotherapy (RT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Itraconazole, Phenytoin and Gemfibrozil on the Drug Levels of BMS-986166 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: BMS-986166|DRUG: Itraconazole|DRUG: Extended Phenytoin Sodium|DRUG: Gemfibrozil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bioavailability of Enasidenib (CC-90007) Sprinkle Formulation Relative to the Reference Tablet Formulation and Effect of Food on the Pharmacokinetics of Sprinkle Formulation in Healthy Adults
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Enasidenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study Testing Two Formulations of Sotagliflozin in Healthy Male and Female Subjects Under Fasted Conditions
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Healthy Subjects
Interventions: DRUG: sotagliflozin (SAR439954)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Phenotypic and Genetic Properties in Male Subjects Affected By Hypohidrotic Ectodermal Dysplasia (ECP-012)
Status: COMPLETED
Conditions: X-linked Hypohidrotic Ectodermal Dysplasia|Hypohidrotic Ectodermal Dysplasia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Use of Transcranial Direct Current Stimulation (TDCS) to Enhance the Rehabilitative Effect of Vision Restoration Therapy
Status: COMPLETED
Conditions: Hemianopia|Quadrantanopia|Scotoma|Visual Field Loss
Interventions: BEHAVIORAL: Vision Restoration Therapy (VRT)|DEVICE: Transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Helicobacter Pylori and Iron Deficiency: Prevalence of Association and Effect of Therapy
Status: WITHDRAWN
Conditions: Anemia, Iron-Deficiency|Helicobacter Pylori
Interventions: DRUG: omeprazole,clarithromycin,amoxicillin (or metronidazole)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Long Term Therapy With High Flow Humidification Compared to Usual Care in Patients With Bronchiectasis (BX)
Status: UNKNOWN
Conditions: Bronchiectasis Adult|Lung Infection|Quality of Life|Humidifier Lung|COPD Exacerbation|COPD Asthma
Interventions: DEVICE: High Flow Humidification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging of Lymphatic Anomalies
Status: COMPLETED
Conditions: Gorham Disease|Lymphatic Diseases|Lymphangiomatosis
Interventions: OTHER: Dynamic Contrast Enhanced Magnetic Resonance Lymphangiography (DCMRL)|OTHER: Heavy Weighted T2 Imaging (T2W)|OTHER: Lymph Node Access
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Modulation of Dyspnea Perception During Exercise in COPD Patients Using Attentional Distraction
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Attentional distraction using IAPS protocol (standardized images)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Phase II Study of Postoperative Concurrent Chemoradiotherapy for Esophageal Squamous Cell Carcinoma (ESO- Shanghai 17)
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophagus Cancer|Esophageal Squamous Cell Carcinoma|Chemoradiotherapy|Radiation Therapy|Postoperative
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Thymus Transplantation With Immunosuppression #950
Status: COMPLETED
Conditions: DiGeorge Anomaly|Complete DiGeorge Anomaly|Complete Atypical DiGeorge Anomaly|Complete DiGeorge Syndrome|Complete Atypical DiGeorge Syndrome
Interventions: BIOLOGICAL: Cultured Thymus Tissue for Implantation (CTTI)|OTHER: Cultured Thymus Tissue Implantation and Parental Parathyroid Transplantation|PROCEDURE: Blood Draw|DRUG: Rabbit anti-thymocyte globulin|DRUG: Cyclosporine|DRUG: Tacrolimus|DRUG: Methylprednisolone or Prednisolone|DRUG: Daclizumab|DRUG: Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Headache Inducing Effects of Cilostazol on Migraine Patients
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Cilostazol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Closed-Loop Versus Conventional Ventilation on Mechanical Power
Status: COMPLETED
Conditions: Mechanical Ventilation|Mechanical Power
Interventions: PROCEDURE: Procedure: INTELLiVENT-ASV|PROCEDURE: Procedure: Conventional ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of the Safety and Efficacy of a Novel Oral Rinse on Oral Health
Status: UNKNOWN
Conditions: Plaque|Gingivitis
Interventions: DEVICE: Experimental Oral Rinse|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Comparison of Arthrocentesis, Arthroscopy and Arthroplasty in the Treatment of Temporomandibular Joint Dysfunction
Status: COMPLETED
Conditions: Temporomandibular Joint Dysfunction
Interventions: PROCEDURE: arthrocentesis|PROCEDURE: arthroscopy|PROCEDURE: arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk for Reoperation After First MTP Joint Arthrodesis
Status: ACTIVE_NOT_RECRUITING
Conditions: Hallux Rigidus|Orthopedic Disorder|Surgery|Complication of Surgical Procedure|Hallux Valgus
Interventions: PROCEDURE: First metatarsophalangeal joint arthrodesis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Protect: Study With Hydroxychloroquine for Prevention and Early Phase Treatment of Coronavirus Disease (COVID-19)
Status: UNKNOWN
Conditions: COVID19|Hydroxychloroquine|Prophylaxis|Treatment|SARS-CoV-2
Interventions: DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study: Characterization of the Immune Phenotype of Patients Allergic to Wasp Venom or Penicillin
Status: COMPLETED
Conditions: Allergy
Interventions: OTHER: Human biological samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Standing Versus Supine 3D Cone Beam Computed Tomography in Patient With Obstructive Sleep Apnea
Status: COMPLETED
Conditions: OSA|Sleep Apnea
Interventions: PROCEDURE: Mandible slacked and captured with Correct Plus™ Impression Material Superfast
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Enriched Oxygen Mixtures in Athletes
Status: COMPLETED
Conditions: Oxidative Stress|Stem Cell Research
Interventions: COMBINATION_PRODUCT: L-HBO|COMBINATION_PRODUCT: HBO|COMBINATION_PRODUCT: 30% O2|COMBINATION_PRODUCT: 50% O2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Revlimid® (Lenalidomide) With Mabthera® (Rituximab) in Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin Lymphoma
Interventions: DRUG: Lenalidomide/Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RISI in the Treatment of Recurrent Metastatic SCC of Thoracic Inlet Lymph Nodes
Status: RECRUITING
Conditions: Brachytherapy|Squamous Cell Carcinomas
Interventions: RADIATION: 3D-printing Template-assisted CT-guided I-125 Seed Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel in Treating Patients With Ovarian Stromal Cancer
Status: COMPLETED
Conditions: Adult Type Ovarian Granulosa Cell Tumor|Ovarian Gynandroblastoma|Ovarian Sertoli-Leydig Cell Tumor|Ovarian Sex Cord Tumor With Annular Tubules|Ovarian Steroid Cell Tumor
Interventions: DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Infections and Mortality in Long-term Care Facilities During the First Wave
Status: COMPLETED
Conditions: Covid19|Death|Infection Viral|Infections, Respiratory|Infection, Coronavirus|Elderly Infection|Old Age; Dementia|Epidemic Disease
Interventions: OTHER: COVID-19 infection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Perioperative Local Anesthesia Block in Spine Surgery
Status: COMPLETED
Conditions: Lumbar Spine Disease|Lumbar Disc Herniation|Lumbar Spinal Stenosis
Interventions: PROCEDURE: Preoperative fluoroscopically-guided dorsal ramus block placed by the operative neurosurgeon
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence Study of Dr. Reddy's Divalproex Sodium Coated Particles in Capsules, 125 mg, Under Fed Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Divalproex Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Energy Supply in Athletes and Untrained Persons With Bronchopulmonary Diseases
Status: UNKNOWN
Conditions: Community-acquired Pneumonia|Bronchitis|Chronic Obstructive Pulmonary Disease|Acute Respiratory Infection
Interventions: DIAGNOSTIC_TEST: bicycle ergometry test with spiroergometry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial to Investigate Scar Improvement Efficacy of RN1001 (Avotermin) After Head and Neck Naevi Excision
Status: UNKNOWN
Conditions: Nevus|Cicatrix
Interventions: DRUG: Avotermin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Evaluation of Sectional Matrix Versus Circumferential Matrix for Reproduction of Proximal Contact
Status: COMPLETED
Conditions: Proximal Contact
Interventions: DEVICE: MD ring and precontoured sectional matrix by TOR VM|DEVICE: Circumferential matrix and tofflemire retainer by Kerr
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Addition to Fascia Iliaca Compartment Block
Status: COMPLETED
Conditions: Children With Fracture Femur
Interventions: PROCEDURE: Fascia iliaca compartment block|PROCEDURE: Fascia iliaca block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Improving Sleep in Nursing Homes
Status: COMPLETED
Conditions: Sleep Deprivation
Interventions: DRUG: Ramelteon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Corticosteroids and / or Arthrographic Distention in the Treatment of Adhesive Capsulitis
Status: UNKNOWN
Conditions: Adhesive Capsulitis|Frozen Shoulder
Interventions: PROCEDURE: Arthrographic distention|DRUG: Intra-articular corticosteroid Depo Medrol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment Of Total Coronary Circulation Time Using TIMI Frame Count Method (TCCT-TIMI)
Status: UNKNOWN
Conditions: Coronary Angiography|Coronary Artery Disease|Coronary Artery Ectasia|Slow-Flow Phenomenon|Coronary Heart Disease
Interventions: PROCEDURE: coronary angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Home Weight Tele-monitoring on the Number of Office Visits in the First Six Weeks of Life in Infants.
Status: COMPLETED
Conditions: Failure to Thrive|Newborn Morbidity
Interventions: OTHER: Home weight monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 1 Study To Evaluate The Pharmacokinetics (PK), Safety, And Bioavailability Of A Modified-Release (MR) Formulation Of Tofacitinib In Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: tofacitinib modified-release (MR) formulation|DRUG: tofacitinib modified-release (MR) formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Vacuum on Fetal and Maternal Complications During Difficult Caesarean Section
Status: COMPLETED
Conditions: Complications; Cesarean Section
Interventions: PROCEDURE: vacuum|PROCEDURE: routine manual maneuvers for fetal head extraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Robot-Assisted vs. Video-Assisted Lobectomy for NSCLC (RAVAR)
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: PROCEDURE: Robot-assisted lobectomy|PROCEDURE: Video-assisted lobectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Efficacy and Safety Extension Study of BMN 110 in Patients With Mucopolysaccharidosis IVA (Morquio A Syndrome)
Status: COMPLETED
Conditions: Mucopolysaccharidosis IV A|Morquio A Syndrome|MPS IVA
Interventions: DRUG: BMN 110 - Weekly|DRUG: BMN 110 - Every Other Week
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Staccato Prochlorperazine Single Dose PK Study
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Prochlorperazine 0.5 mg IV over 5 sec|DRUG: Inhaled prochlorperazine 0.625 mg|DRUG: Inhaled prochlorperazine 1.25 mg|DRUG: Inhaled prochlorperazine 2.5 mg|DRUG: Inhaled prochlorperazine 5 mg|DRUG: Inhaled prochlorperazine 10 mg|DRUG: Inhaled placebo|DRUG: Prochlorperazine 10 mg IV over 5 sec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telehealth Virtual Reality Gaming on Cardiometabolic Health Among Youth With Cerebral Palsy
Status: ACTIVE_NOT_RECRUITING
Conditions: Cerebral Palsy
Interventions: BEHAVIORAL: Virtual Reality Exergaming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Proof of Concept Trial of Gleevec (Imatinib) in Active Diffuse Scleroderma
Status: TERMINATED
Conditions: Scleroderma
Interventions: DRUG: Imatinib mesylate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BIS-Guided Sedation Monitoring
Status: TERMINATED
Conditions: Patients Who Are Mechanically Ventilated and Sedated
Interventions: OTHER: sedation monitoring with RASS score|OTHER: sedation monitoring with BIS-Guided monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Balstilimab Versus Investigator Choice Chemotherapy in Patients With Recurrent Cervical Cancer (BRAVA)
Status: WITHDRAWN
Conditions: Advanced Cancer|Metastatic Cervical Cancer
Interventions: DRUG: Balstilimab (BAL)|DRUG: Topotecan|DRUG: Vinorelbine|DRUG: Gemcitabine|DRUG: Irinotecan|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Butanediol Ingestion on Skeletal Muscle Angiogenesis in Hypoxia
Status: NOT_YET_RECRUITING
Conditions: Ketosis|Hypoxia|Angiogenesis
Interventions: DIETARY_SUPPLEMENT: Normoxic recovery and placebo (NPL)|DIETARY_SUPPLEMENT: Normoxic recovery and ketones (NKE)|DIETARY_SUPPLEMENT: Hypoxic recovery and placebo (HPL)|DIETARY_SUPPLEMENT: Hypoxic recovery and ketones (HKE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Drug Interaction Study of CT1812 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: CT1812|DRUG: tolbutamide|DRUG: dextromethorphan|DRUG: Omeprazole|DRUG: midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 5% KOH Solution vs. Placebo and Diclofenac Gel for the Treatment of Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DEVICE: Solcera|DEVICE: Placebo|DRUG: Solaraze
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of a Monoclonal Antibody Cocktail for the Prevention of COVID-19
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: ADM03820|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study on Communication Comprehension in the Schizophrenic Spectrum
Status: COMPLETED
Conditions: Schizophrenia Simple
Interventions: BEHAVIORAL: Emotional judgment task|BEHAVIORAL: Post-experimental questionnaire|BEHAVIORAL: Recognition task|BEHAVIORAL: Detection task|OTHER: CAPE-42|DIAGNOSTIC_TEST: Trait Emotional Intelligence Questionnaire|DIAGNOSTIC_TEST: Positive And Negative Syndrome Scale|OTHER: Mini International Neuropsychiatric Interview
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Peritubal Infiltration of Bupivacaine in PCNL
Status: UNKNOWN
Conditions: Pain
Interventions: DRUG: Bupivacaine|OTHER: Normal saline infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dual Energy X-ray Absorptiometry (DXA) Comparison Hip Resurfacing Versus Total Hip Arthroplasty (THA)
Status: COMPLETED
Conditions: Osteoarthritis, Hip
Interventions: DEVICE: Hip Resurfacing|DEVICE: Total Hip Arthroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mechanisms of Glucose Lowering Effect of Colesevelam HCl
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: Colesevelam HCL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of QoR-15 in Laparoscopic Cholecystectomy: Sugammadex vs. Neostigmine
Status: COMPLETED
Conditions: Neuromuscular Blockade Reversal Agent|Sugammadex|Neostigmine|Quality of Recovery|Laparoscopic Cholecystectomy
Interventions: DRUG: Sugammadex|DRUG: Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Colorectal Polypectomy Upon Insertion And Withdrawal Or Upon Withdrawal Only?
Status: COMPLETED
Conditions: Colorectal Polyps
Interventions: PROCEDURE: Polyp removal upon insertion and withdrawal|PROCEDURE: Polyp removal upon withdrawal only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multi-cohort Study of Surufatinib Plus Sintilimab in Metastatic NEN and Pancreatic Carcinoma Who Failed Standard Chemotherapy
Status: RECRUITING
Conditions: Neuroendocrine Tumor Grade 3|Neuroendocrine Carcinoma|Pancreatic Carcinoma
Interventions: DRUG: Surufatinib|DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modified Immune Cells (Autologous CAR T Cells) in Treating Patients With Advanced, Recurrent Platinum Resistant Ovarian, Fallopian Tube or Primary Peritoneal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Platinum-Resistant Fallopian Tube Carcinoma|Platinum-Resistant Ovarian Carcinoma|Platinum-Resistant Primary Peritoneal Carcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Refractory Fallopian Tube Carcinoma|Refractory Ovarian Carcinoma|Refractory Primary Peritoneal Carcinoma|Stage III Fallopian Tube Cancer AJCC v8|Stage III Ovarian Cancer AJCC v8|Stage III Primary Peritoneal Cancer AJCC v8|Stage IIIA Fallopian Tube Cancer AJCC v8|Stage IIIA Ovarian Cancer AJCC v8|Stage IIIA Primary Peritoneal Cancer AJCC v8|Stage IIIA1 Fallopian Tube Cancer AJCC v8|Stage IIIA1 Ovarian Cancer AJCC v8|Stage IIIA2 Fallopian Tube Cancer AJCC v8|Stage IIIA2 Ovarian Cancer AJCC v8|Stage IIIB Fallopian Tube Cancer AJCC v8|Stage IIIB Ovarian Cancer AJCC v8|Stage IIIB Primary Peritoneal Cancer AJCC v8|Stage IIIC Fallopian Tube Cancer AJCC v8|Stage IIIC Ovarian Cancer AJCC v8|Stage IIIC Primary Peritoneal Cancer AJCC v8|Stage IV Fallopian Tube Cancer AJCC v8|Stage IV Ovarian Cancer AJCC v8|Stage IV Primary Peritoneal Cancer AJCC v8|Stage IVA Fallopian Tube Cancer AJCC v8|Stage IVA Ovarian Cancer AJCC v8|Stage IVA Primary Peritoneal Cancer AJCC v8|Stage IVB Fallopian Tube Cancer AJCC v8|Stage IVB Ovarian Cancer AJCC v8|Stage IVB Primary Peritoneal Cancer AJCC v8
Interventions: BIOLOGICAL: PRGN-3005 UltraCAR-T cells|BIOLOGICAL: PRGN-3005 UltraCAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fasting Bioequivalence Study of 2 Progesterone Soft Capsules 200 mg in 66 Healthy Female Subjects Under Vaginal Route
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Progesterone 200 mg Soft Capsule (JSC "Farmak", Ukraine)|DRUG: Utrogestan® 200 mg Soft Capsule (Manufacturer: Cyndea Pharma, S.L., Spain, MAH: Laboratoires Besins International, France)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cystic Fibrosis and Gut Dysmotility: The Effect of Polyethylene Glycol (PEG) on Intestinal Transit
Status: COMPLETED
Conditions: Cystic Fibrosis Gastrointestinal Disease
Interventions: DRUG: Polyethylene Glycol 3350|DEVICE: SmartPill Motility System & PillCam Patency Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Novel Probiotic Microbial Composite™ to Treat Undernourished Young Children
Status: UNKNOWN
Conditions: Quality of Life|Malnutrition|Growth Arrest
Interventions: DIETARY_SUPPLEMENT: Probiotic Microbial Composite|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ketamine/Midazolam Premedication Versus Pre-extubation Ketofol on Recovery Profile in Pediatrics Undergoing Adenotonsillectomy.
Status: RECRUITING
Conditions: Emergence Delirium
Interventions: DRUG: ketamine/midazolam|DRUG: Ketofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Propolis or Metformin Administration on Glycemic Control in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Propolis|DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Value of Traction in Treatment of Lumbar Radiculopathy
Status: COMPLETED
Conditions: Sciatica|Radiculopathy|Spinal Diseases|Musculoskeletal Diseases|Neuromuscular Diseases|Intervertebral Disk Displacement
Interventions: OTHER: Physical therapy rehabilitation|OTHER: Physical therapy rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Determination of a Proper Needle Entry Point; Effects of Skin Compression With an Indicator on Radiation Exposure Time of Fluoroscopically Guided Transforaminal Epidural Block in Obese Patients
Status: COMPLETED
Conditions: Low Back Pain Due to Spinal Nerve Compression
Interventions: PROCEDURE: skin compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Hsp90 Inhibitor AUY922 in Treating Older Patients With Advanced Solid Malignancies
Status: TERMINATED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: Hsp90 inhibitor AUY922|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Steady-state Pharmacokinetics of Ceftazidime/Avibactam in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Ceftazidime/avibactam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate Efficacy and Safety of ADC3680 in Subjects With Inadequately-Controlled Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: ADC3680|DRUG: Placebo|DRUG: montelukast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: "Lung Barometric Measurements in Normal And in Respiratory Distressed Lungs"
Status: RECRUITING
Conditions: Ventilator-Induced Lung Injury|Ventilatory Failure|Ventilator Lung|Ventilation Therapy; Complications|Ventilator Associated Pneumonia
Interventions: OTHER: PEEP-step method
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination Study of GSK1120212 With Gemcitabine in Subjects With Solid Tumors
Status: COMPLETED
Conditions: Leukaemia, Myelocytic, Acute
Interventions: DRUG: GSK1120212|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Treatment With Alfuzosin Increase Success Rates of (SWL) Shock Wave Lithotripsy
Status: UNKNOWN
Conditions: Urolithiasis|Nephrolithiasis|Ureterolithiasis
Interventions: DRUG: Alpha blocker-alfuzosin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sunitinib Malate, Hormone Ablation and Radiation Therapy in Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Leuprolide|DRUG: Goserelin|DRUG: Sunitinib Malate|DRUG: Casodex|RADIATION: Radiation Therapy (RT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Similarity Study in Healthy Male Subjects to Evaluate Pharmacokinetics, Pharmacodynamics, Safety and Immunogenicity of LY06006 Versus US-Prolia and EU-Prolia by Single-dose Subcutaneous Injection
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: LY06006 (Denosumab Biosimilar)|BIOLOGICAL: US-Prolia (Denosumab)|BIOLOGICAL: EU-Prolia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Brown Adipose Tissue Pilot
Status: ACTIVE_NOT_RECRUITING
Conditions: Aging
Interventions: OTHER: Maximal oxygen consumption (V02 max)|OTHER: Brown adipose tissue (BAT) imaging|OTHER: Muscle function testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Primaquine Double Dose for Radical Cure of Plasmodium Vivax in Colombia
Status: WITHDRAWN
Conditions: Malaria, Vivax|Relapse
Interventions: DRUG: Primaquine double dose over 14 days|DRUG: Primaquine single dose over 14 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Riluzole for Drug-Refractory Irritability in Autism Spectrum Disorders
Status: COMPLETED
Conditions: Autism Spectrum Disorders
Interventions: DRUG: Riluzole|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Breastfeeding Education and Support Trial for Obese Women (BESTOW)
Status: COMPLETED
Conditions: Exclusive Breastfeeding|Breastfeeding Initiation
Interventions: BEHAVIORAL: Breastfeeding Peer Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Temozolomide in Treating Patients With Recurrent Glioblastoma Multiforme or Other Malignant Glioma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: temozolomide|GENETIC: protein expression analysis|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: diagnostic laboratory biomarker analysis|OTHER: immunoenzyme technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug-Coated Chocolate PTA Balloon in Patients With Peripheral Arterial Disease - The ENDURE Trial
Status: COMPLETED
Conditions: Peripheral Vascular Disease
Interventions: DEVICE: Paclitaxel Coated Chocolate Balloon Angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficiency of Vitamin D3 and 25-hydroxyvitamin D3 on Transcriptomic Changes of Low Vitamin D Responders
Status: COMPLETED
Conditions: Vitamin D Receptor Target Gene Expression|Serum 25(OH)D Concentration
Interventions: DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The CanDo (Canadian Donor Milk) Trial
Status: RECRUITING
Conditions: Small for Gestational Age at Delivery|Gestational Diabetes|type1diabetes|Type2diabetes
Interventions: DIETARY_SUPPLEMENT: Human donor milk|DIETARY_SUPPLEMENT: Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Muscle Protein Synthesis After Whole Egg vs. Egg White Consumption
Status: COMPLETED
Conditions: Hypertrophy
Interventions: BEHAVIORAL: Resistance Exercise|OTHER: Whole Eggs|OTHER: Egg Whites
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: EFFECT OF PRANAYAMA YOGA ON COPD
Status: RECRUITING
Conditions: Asthma, Chronic Obstructive Pulmonary Disease (COPD), or Chronic Lung Disease (E.G., Chronic Bronchitis and Restrictive Lung Diseases Such as Asbestosis)|The Effect of Yoga, Paranayama Yoga Practice on Respiratory Diseases
Interventions: BEHAVIORAL: Pranayama Yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: THC Memory & Reward Learning Pilot
Status: RECRUITING
Conditions: Marijuana|THC|Cannabis
Interventions: DRUG: Marijuana, Hash, THC, or Grass|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Tolerability of Aripiprazole in Adolescents With Schizophrenia or Children and Adolescents With Bipolar I Disorder, Manic or Mixed Episode With or Without Psychotic Features.
Status: TERMINATED
Conditions: Adolescent Schizophrenia|Child or Adolescent Bipolar I Disorder, Manic or Mixed Episode With or Without Psychotic Features
Interventions: DRUG: Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimized Cardioprotection Therapy in Obese Subjects With CAD
Status: UNKNOWN
Conditions: Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))|Obesity|Adiposis; Heart
Interventions: PROCEDURE: PCI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Multiple Dose Study Of PF-04620110 In Healthy Overweight Or Obese Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-04620110|DRUG: PF-04620110|DRUG: PF-04620110|DRUG: PF-04620110|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Hyaluronic Acid vs. Hyaluronic Acid on Knee Osteoarthritis
Status: UNKNOWN
Conditions: Physical Activity
Interventions: OTHER: hyaluronic acid|OTHER: hyaluronic acid combined corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Water-soluble Olive Extract Supplementation
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Olive Extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mechanism of Indocyanine Green-based Photodynamic Therapy for Treating Periodontitis
Status: UNKNOWN
Conditions: Periodontal Diseases
Interventions: DRUG: Photodynamic Therapy with indocyanine green and diode laser|PROCEDURE: Mechanical debridement alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PLGA-coated Biphasic Calcium Phosphate in Sinus Lift
Status: COMPLETED
Conditions: Sinus Floor Augmentation
Interventions: DEVICE: Non-coated HA/TCP particles|DEVICE: PLGA-coated HA/TCP particles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Usability of Vibro-tactile Stimulation to Treat Spasmodic Dysphonia
Status: RECRUITING
Conditions: Spasmodic Dysphonia|Laryngeal Dystonia
Interventions: DEVICE: Vibro-tactile stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minocycline as add-on to Interferon Beta-1a [IFN Beta-1a] (Rebif®) in Relapsing-Remitting Multiple Sclerosis [RRMS]
Status: TERMINATED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Minocycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PENS T6 With Ambulatory Self-applied Patch vs Conventional Procedure
Status: COMPLETED
Conditions: Weight Loss
Interventions: PROCEDURE: Self-applied patch|PROCEDURE: Conventional procedure|DIETARY_SUPPLEMENT: 1200 Kcal/day diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Trial of Manlikang in Reducing Salt Intake and Blood Pressure Among Patients With Hypertension
Status: COMPLETED
Conditions: Hypertension|Hypertension With Abnormal Renal Function
Interventions: DIETARY_SUPPLEMENT: formula salt with very low sodium (Brand name: Manlikang)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity and Reactogenicity of GSK Bio DTPa-HBV-IPV and Hib Vaccines When Coadministered to Healthy Infants
Status: COMPLETED
Conditions: Diphtheria|Poliomyelitis|Hepatitis B|Tetanus|Acellular Pertussis
Interventions: BIOLOGICAL: Pediarix TM, Infanrix penta TM|BIOLOGICAL: Hiberix TM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Clinical Significance of Sentinel Lymph Node Imaging Combined With Imaging Examination in Pelvic and Peritoneal Lymphadenectomy for Endometrial Carcinoma
Status: UNKNOWN
Conditions: Endometrial Carcinoma|Lymphadenectomy
Interventions: PROCEDURE: Pelvic and Peritoneal Lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparation of CLASS Combined With Phacoemulsification and CLASS Alone in the Treatment of Primary Open Angle Glaucoma
Status: UNKNOWN
Conditions: Glaucoma, Open-Angle
Interventions: PROCEDURE: phacoemulsification;
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous and Donor-derived CD7 CAR-T Therapy in Refractory or Relapsed T-cell Acute Lymphoblastic Leukemia/Lymphoma
Status: RECRUITING
Conditions: T-cell Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia, in Relapse|Refractory Acute Lymphoblastic Leukemia
Interventions: DRUG: Autologous CD7 CAR T-cell|DRUG: Prior-HSCT donor-derived CD7 CAR T-cell|DRUG: New donor-derived CD7 CAR T-cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CIK Cell Transfusion Plus Chemotherapy as Adjuvant Therapy for Stage IB-IIIA Non-Small Cell Lung Cancer (NSCLC)
Status: WITHDRAWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Autologous CIK Transfusion plus Chemotherapy|DRUG: chemotherapy alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact Study of 2 Therapeutic Strategy for Aggressive Remitting Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: OTHER: mitoxantrone - immunomodulator|OTHER: natalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cervical Nodal Mets in Squamous Cell Carcinoma of H&N - MRI, FDG-PET, & Histopathologic Correlation
Status: COMPLETED
Conditions: Head and Neck Cancer|Carcinoma, Squamous Cell|Head and Neck Cancers
Interventions: RADIATION: PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: To Compare the Efficacy and Tolerability of A. Paniculata/A. Chilensis in Individuals With URTI
Status: COMPLETED
Conditions: Upper Respiratory Tract Infection
Interventions: DRUG: A. Paniculata|DRUG: A. Chilensis|DRUG: A. Paniculata and A. Chilensis|DRUG: Microcrystalline cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Brief Negotiation Interview Chatbot to Improve Buprenorphine Engagement Among Justice-Involved Individuals
Status: COMPLETED
Conditions: Opioid Use Disorder, Moderate|Opioid Use Disorder, Severe|Criminal Behavior
Interventions: BEHAVIORAL: BNI Chatbot|BEHAVIORAL: OUD Education & Treatment Resources
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microclots and Neutrophil Activation as Potential Indicators for Stroke Risk and Reperfusion Failure
Status: NOT_YET_RECRUITING
Conditions: Ischemic Stroke
Interventions: DIAGNOSTIC_TEST: 3D rotational digital tomography|DIAGNOSTIC_TEST: Atomic Force Microscopy|DIAGNOSTIC_TEST: Micro-Computertomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Varlilumab (Anti-CD27) and Ipilimumab and CDX-1401 in Patients With Unresectable Stage III or IV Melanoma
Status: TERMINATED
Conditions: Unresectable Stage III or Stage IV Melanoma
Interventions: DRUG: Combination of varlilumab and ipilimumab|DRUG: Cohort A: varlilumab & ipilimumab; Cohort B: varlilumab, ipilimumab, CDX-1401 & poly-ICLC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Nifedipine and Metoprolol on Blood Pressure Variability in Northern Chinese
Status: UNKNOWN
Conditions: Hypertension
Interventions: DRUG: metoprolol|DRUG: Nifedipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cannabidiol in Children With Refractory Epileptic Encephalopathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Epileptic Encephalopathy
Interventions: DRUG: CanniMed® 1:20
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effect of the Low FODMAP Diet in Children With Functional Abdominal Pain.
Status: COMPLETED
Conditions: Functional Abdominal Pain Syndrome
Interventions: OTHER: The low FODMAP diet.|OTHER: The diet based on NICE guidelines.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Polymerase Chain Reaction (PCR) and Cultivation of the Peritoneal Fluid at Operation for Appendicitis and Postoperative Enteral Antibiotic Treatment
Status: UNKNOWN
Conditions: Appendicitis Acute
Interventions: DIAGNOSTIC_TEST: Cultivation and PCR within 24 hours|DRUG: Enteral antibiotics
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase II Study With Trastuzumab + Paclitaxel in Locally Advanced HER2+ Tumors or Epirubicin + Taxotere in HER2- Tumors
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Trastuzumab|DRUG: Paclitaxel|DRUG: Epirubicin|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of One Dose of Seasonal Trivalent Influenza Virus Vaccine (TIVf, Purified Surface Antigen, Inactivated, Egg Derived) in Adults Aged 18 Years and Above
Status: COMPLETED
Conditions: Human|Influenza
Interventions: BIOLOGICAL: Trivalent influenza virus vaccine (TIVf)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics of Omega-3 Monoglycerides
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Omega-3 + vitamin K2 (monoacylglycerol form)|DIETARY_SUPPLEMENT: Omega-3 + vitamin K2 (ethyl ester)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Mesenchymal Stem Cells in Spinal Cord Injury (SCI) Patients
Status: UNKNOWN
Conditions: Spinal Cord Injury
Interventions: PROCEDURE: Autologous Mesenchymal Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Ranolazine on Postprandial Glucagon in Subjects With Type 2 Diabetes.
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Ranolazine|DRUG: Placebo|DRUG: Exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: S9720 Combination Chemotherapy in Treating Patients With Metastatic, Recurrent, or Refractory Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Cancer
Interventions: DRUG: amifostine trihydrate|DRUG: carboplatin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT