pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Anlotinib Combined With Carboplatin/Paclitaxel as First-line Treatment in Patients With Advanced Ovarian Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Neoplasms|Fallopian Tube Neoplasms|Neoplasms by Site|Genital Neoplasms, Female|Neoplasms, Glandular and Epithelial|Neoplasms by Histologic Type|Carcinoma, Ovarian Epithelial|Ovarian Diseases|Genital Diseases, Female|Endocrine System Diseases|Carcinoma|Anlotinib|Angiogenesis|Antineoplastic Agents|Tyrosine Kinase Inhibitor
Interventions: DRUG: Drug: Anlotinib|DRUG: Drug: Carboplatin/Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Clopidogrel Versus Ticagrelor Therapy for Atherosclerotic Plaque Inflammation
Status: COMPLETED
Conditions: Plaque, Atherosclerotic
Interventions: DRUG: Clopidogrel|DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short or Long Antibiotic Regimes in Orthopaedics
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteomyelitis|Prosthetic Joint Infection|Diabetic Foot
Interventions: OTHER: Shorter Systemic Antibiotics|OTHER: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-Dose Iodine I 131 Metaiodobenzylguanidine, Topotecan, and Peripheral Stem Cell Transplant in Treating Young Patients With Relapsed Stage 4 Neuroblastoma or Primary Resistant High-Risk Neuroblastoma
Status: WITHDRAWN
Conditions: Neuroblastoma
Interventions: DRUG: iodine I 131 metaiodobenzylguanidine|DRUG: topotecan hydrochloride|PROCEDURE: chemotherapy|PROCEDURE: peripheral blood stem cell transplantation|PROCEDURE: radioisotope therapy|PROCEDURE: radionuclide imaging|PROCEDURE: radiosensitization|PROCEDURE: total-body irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fostering Healthy Futures for Teens: An RCT
Status: ACTIVE_NOT_RECRUITING
Conditions: Child Abuse|Child Neglect|Risk Behavior|Delinquency|Mental Health Impairment|Substance Use|Educational Problems|Adolescent Development|Adolescent Behavior|Sexual Behavior|Child Maltreatment
Interventions: BEHAVIORAL: FHF-T
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Version 2 of the Smoking Cessation Smartphone App "Smiling Instead of Smoking" (SiS)
Status: COMPLETED
Conditions: Smoking Cessation|Smoking, Tobacco
Interventions: BEHAVIORAL: Smiling Instead of Smoking (SiS) App Version 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Volumes of Local Anesthetics on the Efficiency and Safety of Stellate Ganglion Block for CRPS of the Arm
Status: WITHDRAWN
Conditions: Complex Regional Pain Syndromes
Interventions: PROCEDURE: stellate ganglion block with ropivacaine 0.2% 5 mL|PROCEDURE: stellate ganglion block wit ropivacaine 0.2% 2 mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Web basEd soCial Media tecHnology to Improvement in Adherence to Dual anTiplatelet Therapy Following Drug-Eluting Stent Implantation
Status: UNKNOWN
Conditions: Coronary Disease
Interventions: BEHAVIORAL: Usual Text Messages|BEHAVIORAL: Personalized Reminders|BEHAVIORAL: Interactive Responses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Early Discovery of Ischemia After Replantation Surgery of the Extremities
Status: RECRUITING
Conditions: Ischemia|Blood Circulation Disorder|Carbon Dioxide|Biosensing Techniques|Amputation, Traumatic
Interventions: DEVICE: IscAlert
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 1 First in Human Study to Assess Safety and Tolerability of AL101
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: AL101|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Effects of CX-3543 in Patients With Relapsed or Refractory B-Cell Chronic Lymphocytic Leukemia
Status: WITHDRAWN
Conditions: B-Cell Chronic Lymphocytic Leukemia
Interventions: DRUG: CX-3543
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Scalp Block on Hemodynamic Stability and Opioid Consumption During Craniotomy
Status: UNKNOWN
Conditions: Craniotomy
Interventions: PROCEDURE: Scalp block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: E7050 in Combination With Cetuximab Versus Cetuximab Alone in the Treatment of Platinum-Resistant Squamous Cell Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Platinum-Resistant Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: E7050|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role Of Empiric Dilation In Patients With Dysphagia With Normal Endoscopy
Status: TERMINATED
Conditions: Dysphagia With Normal Endoscopy
Interventions: PROCEDURE: Dilation of the esophagus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Anticoagulation in Gastroesophageal Varices and JAK2 Mutation
Status: UNKNOWN
Conditions: Gastroesophageal Varices|JAK2 Mutation|Myeloproliferative Neoplasm
Interventions: DRUG: Anticoagulation Agents
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Role of Biomarker in Serum, Cerebrospinal Fluid and Parenchyma in the Context of Aneurysmal Subarachnoid Hemorrhage.
Status: UNKNOWN
Conditions: Aneurysmal Subarachnoid Hemorrhage
Interventions: PROCEDURE: Biomarker in serum, liquor, micro-dialysate|PROCEDURE: Biomarker in serum and in liquor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Temozolomide and Survivin Long Peptide Vaccine (SurVaxM) for the Treatment of Patients With Progressing Metastatic Neuroendocrine Tumors
Status: NOT_YET_RECRUITING
Conditions: Digestive System Neuroendocrine Neoplasm|Lung Neuroendocrine Neoplasm|Malignant Solid Neoplasm|Pancreatic Neuroendocrine Neoplasm
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|BIOLOGICAL: Incomplete Freund''s Adjuvant|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Sargramostim|BIOLOGICAL: SVN53-67/M57-KLH Peptide Vaccine|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human Salivary Gland Disposition of Alda-341 in Patients Undergoing Salivary Gland Surgery
Status: COMPLETED
Conditions: Submandibular Gland Tumor|Parotid Gland Tumor
Interventions: DRUG: Alda-341
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Is Needle Knife Fistulotomy An Effective First Step Strategy For All ERCPs?
Status: COMPLETED
Conditions: ERCP|Biliary Disease Tract|Biliary Disease
Interventions: PROCEDURE: Needle knife fistulotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Supplementation With Creatine on the Recovery of Ischemic Stroke: A Randomized Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: Stroke, Ischemic
Interventions: DIETARY_SUPPLEMENT: Creatine monohydrate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of RESTEN-MP When Used in Conjunction With a Bare Metal Stent in Coronary Arteries
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Restenosis
Interventions: DRUG: RESTEN-MP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET/CT Guided Antifungal Stewardship in Invasive Pulmonary Aspergillosis
Status: COMPLETED
Conditions: Aspergillosis and Haematological Malignancy
Interventions: DEVICE: imaging 18F-FDG-PET/CT|BIOLOGICAL: Blood collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy (HB-adMSCs) for the Treatment of Alzheimer's Disease
Status: WITHDRAWN
Conditions: Alzheimer Disease
Interventions: BIOLOGICAL: HB-adMSCs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alvocidib, Cytarabine, and Mitoxantrone in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Secondary Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: alvocidib|DRUG: cytarabine|DRUG: mitoxantrone hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tislelizumab Combined With Chemotherapy as Neoadjuvant Therapy for Stage IIIA-IIIB (N2) Lung Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Lung Squamous Cell Carcinoma|Neoadjuvant Therapy|Immunotherapy
Interventions: DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the iStent in Combo With Cataract Surgery in Newly Diagnosed Open Angle Glaucoma or OH Patients.
Status: COMPLETED
Conditions: Open-Angle Glaucoma
Interventions: DEVICE: Glaucoma Surgery|PROCEDURE: cataract surgery only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UCLM802 (Anti-Mesothelin CAR-T) Cell Injection in Patients With Mesothelin-positive Advanced Malignant Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Solid Tumor
Interventions: BIOLOGICAL: UCLM802 Cell Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dermacyd PH_DETINBACK Tangerine Mix (Lactic Acid) - Photo Evaluation
Status: COMPLETED
Conditions: Hygiene
Interventions: DRUG: Lactic Acid (Dermacyd PH_DETINBACK Tangerine Mix)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: First in Human Study to Evaluate the Safety and Tolerability of GEM103 in Geographic Atrophy Secondary to Dry Age Related Macular Degeneration
Status: COMPLETED
Conditions: Dry Age-related Macular Degeneration|Geographic Atrophy|Macular Degeneration|Retinal Disease|Retinal Degeneration
Interventions: BIOLOGICAL: GEM103
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Connecting Families to Improve Parental Self-efficacy and Parent Psychosocial and Infant Health Outcomes in the NICU
Status: NOT_YET_RECRUITING
Conditions: Self Efficacy|Infant Development|eHealth|Mental Health Wellness 1
Interventions: BEHAVIORAL: CNH+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Compare the Relative Bioavailability of Two 200 Mg Tramadol Hydrochloride Tablet Products Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tramadol HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Trial Comparing Cataract Surgery With Triple-DMEK in Patients With Cataract and Fuchs Endothelial Corneal Dystrophy
Status: NOT_YET_RECRUITING
Conditions: Cataract Surgery|Cataract and Fuchs Endothelial Corneal Dystrophy
Interventions: PROCEDURE: Intervention group /arm 1 (Cataract surgery alone)|PROCEDURE: Control group /arm 2: Corneal transplantation as Descemet Membrane Endothelial Keratoplasty (DMEK) in combination with cataract surgery (triple-DMEK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Sticky Bone With or Without EDTA for Treatment of Gingival Recession
Status: RECRUITING
Conditions: Gingival Recession
Interventions: PROCEDURE: Sticky bone and EDTA|PROCEDURE: Sticky bone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficacy of Behavioral Approaches for Treatment of Insomnia
Status: TERMINATED
Conditions: Primary Insomnia
Interventions: BEHAVIORAL: Cognitive Behavior Therapy-Insomnia|BEHAVIORAL: Focus of Attention|BEHAVIORAL: Combined-CBT-I and FOA Group|BEHAVIORAL: Sleep Hygiene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Anti PD-L1 Antibody + Anti CTLA-4 Antibody in Combination With Hormone Therapy in Patients With Hormone Receptor Positive HER2-negative Recurrent or Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Durvalmab&Tremelimumab&Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Profile of Toxic Substances and Nicotine in Electronic Cigarettes
Status: COMPLETED
Conditions: Tobacco Abuse Smoke
Interventions: OTHER: Own Brand cigarette|OTHER: one high 2,4% nicotine|OTHER: original 7,4 mg nicotine|OTHER: nicotine free|OTHER: Ego 9mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Stellate Ganglion Block Combined With Facial Nerve Block on the Treatment of Idiopathic Facial Paralysis
Status: COMPLETED
Conditions: Peripheral Facial Palsy
Interventions: PROCEDURE: Stellate Ganglion Block|PROCEDURE: Facial Nerve Block|DRUG: Mecobalamin Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Personalized Atrial Septostomy for Heart Failure
Status: ENROLLING_BY_INVITATION
Conditions: Heart Failure|Heart Failure, Diastolic
Interventions: PROCEDURE: Personalized atrial septostomy with combined use of radiofrequency-ablation and balloon-dilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Abemaciclib (LY2835219) in Participants With Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Abemaciclib|DRUG: Anastrozole|DRUG: Letrozole|DRUG: Placebo|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Preliminary Effectiveness of AV650 in Patients With Spasticity Due to Spinal Cord Injury
Status: TERMINATED
Conditions: Muscle Spasticity
Interventions: DRUG: tolperisone HCl (AV650)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ophthalmic Phentolamine Mesylate in Glaucoma
Status: COMPLETED
Conditions: Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Phentolamine Mesylate Ophthalmic Solution 1%|OTHER: Phentolamine Mesylate Ophthalmic Solution Vehicle (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HSK16149 for Perioperative Analgesia in Orthopedic Surgery
Status: COMPLETED
Conditions: Post-operative Pain
Interventions: DRUG: HSK16149 capsule|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single and Multiple Rising Dose Study of Safety and PK of Metyrapone/Oxazepam Combination (EMB-001)
Status: COMPLETED
Conditions: Cocaine Use Disorder|Tobacco Use Disorder
Interventions: DRUG: metyrapone & oxazepam|DRUG: metyrapone & oxazepam|DRUG: metyrapone & oxazepam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Two Treatment Combinations, Gemcitabine and Nab-Paclitaxel With 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan for Older Patients With Pancreatic Cancer That Has Spread
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Pancreatic Adenocarcinoma|Stage IV Pancreatic Cancer AJCC v8
Interventions: DRUG: Fluorouracil|DRUG: Gemcitabine|DRUG: Gemcitabine Hydrochloride|DRUG: Leucovorin|DRUG: Leucovorin Calcium|DRUG: Liposomal Irinotecan|DRUG: Nab-paclitaxel|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Muscle Energy Technique (MET) Versus Stretching Exercises In Acute And Subacute Postural Neck Pain
Status: RECRUITING
Conditions: Cervical Pain
Interventions: OTHER: Muscle Energy Technique|OTHER: Stretching Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Telehome Monitoring for Chronic Disease Management
Status: COMPLETED
Conditions: Heart Failure|Pulmonary Disease, Chronic Obstructive|Hypertension|Diabetes Mellitus
Interventions: OTHER: Telehome Care Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Trial to Assess the Safety and Efficacy of Investigational Product in Patients Due to Hypospadias Treatment Failure
Status: SUSPENDED
Conditions: Hypospadias
Interventions: DRUG: "Ex vivo" expanded autologous human oral epithelium containing stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment for Knee Osteoarthritis With Injections of BMC at the Bone-cartilage Interface. Pilot Study
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: BIOLOGICAL: Injection of autologous concentrated bone marrow aspirate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy to the Head in Preventing Brain Metastases in Women Receiving Trastuzumab and Chemotherapy for Metastatic or Locally Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: trastuzumab|DRUG: chemotherapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: High-voltage Pulsed Radiofrequency on Gasserian Ganglion to Treat Patients With Primary Trigeminal Neuralgia
Status: COMPLETED
Conditions: Idiopathic Trigeminal Neuralgia
Interventions: DEVICE: High-voltage pulsed radiofrequency|DRUG: Nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single-incision Versus Retropubic Mid-Urethral Sling (Solyx) for SUI During Minimally Invasive Sacrocolpopexy
Status: RECRUITING
Conditions: Stress Urinary Incontinence|Pelvic Floor Disorders
Interventions: DEVICE: RP Sling|DEVICE: SIS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Cyclosporine A Versus Tacrolimus on Response to Antiviral Therapy After Hepatitis C Genotype -4 Recurrence Post Liver Transplantation
Status: COMPLETED
Conditions: Liver Transplantation
Interventions: DRUG: Cycloserine,Tacrolimus
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TXI for the Recognition of Adenomas in Colonoscopy
Status: COMPLETED
Conditions: Colorectal Polyp
Interventions: DIAGNOSTIC_TEST: TXI Light Imaging|DIAGNOSTIC_TEST: WLI Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Roll-over Study to Provide Continued Treatment With Lyophilized Pegaspargase (S95014) in Pediatric Patients With Acute Lymphoblastic Leukemia (ALL)
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Lyophilized S95014
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing HEPES-buffered With Bicarbonate-buffered as Handling Media During the ICSI Procedure on Live Birth Rate
Status: COMPLETED
Conditions: Infertility
Interventions: OTHER: Bicarbonate-buffered handling medium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: To Enhance Cognition in Late Life Depression Using Transcranial Direct Current Stimulation
Status: COMPLETED
Conditions: Cognition|Depression
Interventions: DEVICE: Active TDCS|DEVICE: Sham TDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Neoplasm Malignant|Renal Cell Carcinoma|Hormone Receptor Positive Breast Carcinoma|Metastatic Castration-resistant Prostate Cancer|Colorectal Cancer
Interventions: DRUG: XL092|DRUG: Atezolizumab|DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Scaling-up Psychological Interventions With Syrian Refugees in Switzerland (STRENGTHS_CH): RCT
Status: COMPLETED
Conditions: Distress|PTSD|Anxiety|Depression|Trauma|Functional Disabilities|Common Mental Health Problems
Interventions: BEHAVIORAL: Problem Management Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study With Azacitidine in Pediatric Subjects With Newly Diagnosed Advanced Myelodysplastic Syndrome (MDS) and Juvenile Myelomonocytic Leukemia (JMML)
Status: COMPLETED
Conditions: Myelodysplastic Syndrome|Leukemia, Myelomonocytic, Juvenile
Interventions: DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Vildagliptin Compared to Metformin in Drug Naive Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: vildagliptin|DRUG: Metformin Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diabetic Macular Edema Treated With Ozurdex (DMEO)
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Dexamethasone Implant|DRUG: Anti-VEGF injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Using DNA-Typing and Erythrocyte Microparticle Analysis to Detect Blood Doping
Status: UNKNOWN
Conditions: Blood Disease|Blood Transfusion, Autologous|Blood Doping|Blood Transfusion, Homologous
Interventions: BIOLOGICAL: Homologous Blood Transfusion|BIOLOGICAL: Autologous Blood Transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of High-dose Pitavastatin on Glucose Control in Patients With Metabolic Syndrome
Status: UNKNOWN
Conditions: Metabolic Syndrome
Interventions: DRUG: Pitavastatin 4 mg orally daily|DRUG: Atorvastatin 20 mg orally daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Idarubicin + Cytarabine and Lenalidomide in Patients With Myelodysplastic Syndrome (MDS), Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Myelodysplastic Syndrome|Acute Myeloid Leukemia
Interventions: DRUG: Idarubicin|DRUG: Cytarabine|DRUG: Lenalidomide (Revlimid®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Aspen Device Versus Pedicle Screws for Supplemental Posterior Fixation in Lumbar Interbody Fusion
Status: COMPLETED
Conditions: Degeneration of Lumbar Intervertebral Disc
Interventions: DEVICE: Aspen Spinous Process Fixation Device|DEVICE: Pedicle Screws
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Study , Safety and Tolerability of Brincidofovir for Post Exposure Prophylaxis of Ebola
Status: WITHDRAWN
Conditions: Ebola Virus Disease
Interventions: DRUG: Brincidofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rintatolimod, Celecoxib and Interferon Alpha 2b With Pembrolizumab For the Treatment of Patients With Metastatic or Unresectable Triple Negative Breast Cancer
Status: RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Triple-Negative Breast Carcinoma|Unresectable Triple-Negative Breast Carcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Celecoxib|PROCEDURE: Computed Tomography|BIOLOGICAL: Interferon Alpha-2|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Pembrolizumab|DRUG: Rintatolimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Serious Game for Patients With Bipolar Disorder Involved in a Psychoeducation Group
Status: TERMINATED
Conditions: Bipolar Disorders|Euthymic Status
Interventions: BEHAVIORAL: Bipolife® group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study for Adolescents and Adults With Ornithine Transcarbamylase Deficiency to Evaluate Safety and Tolerability of ARCT-810
Status: ACTIVE_NOT_RECRUITING
Conditions: Ornithine Transcarbamylase Deficiency|OTC Deficiency|OTCD
Interventions: BIOLOGICAL: ARCT-810|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Subcutaneous Cardiac Monitoring of Patients With BTK Inhibitors
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: Insertable subcutaneous cardiac monitor (BIOMONITOR IIIm®, Biotronik®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Single Doses GSK159797 On Patient Safety And Lung Function In Patients With Mild To Moderate Asthma
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK159797
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Integrating Use of Self-Affirmation Content Into a Mobile App to Promote Quit Attempts With Text-Based Smoking Cessation Intervention Messaging
Status: COMPLETED
Conditions: Number of Quit Attempts
Interventions: BEHAVIORAL: Self-affirmation induction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Assess the Pharmacokinetics of the Hydrocodone Extended-Release Tablet (CEP-33237) in Subjects With Normal Renal Function and Subjects With Varying Degrees of Renal Impairment
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Hydrocodone Bitartrate extended-release tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Roll-over Study to Assess Safety of Lixivaptan in Participants With ADPKD Who Completed Study PA-ADPKD-303
Status: TERMINATED
Conditions: Polycystic Kidney Disease, Adult
Interventions: DRUG: Lixivaptan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tazemetostat and Venetoclax in Relapsed/Refractory Non-Hodgkin Lymphoma
Status: RECRUITING
Conditions: Lymphoma, Non-Hodgkin|Diffuse Large B Cell Lymphoma|Follicular Lymphoma
Interventions: DRUG: Venetoclax|DRUG: Tazemetostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Offloading for Diabetic Foot Ulcers With PulseFlow: A Prospective Study
Status: COMPLETED
Conditions: Diabetic Foot Ulcer|Offloading
Interventions: DEVICE: Offloading boot: PulseFlow
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Natural History and Patient Journey in Atrial Fibrillation: a Nationwide Linked Electronic Health Records Study of 5.6 Million Individuals.
Status: UNKNOWN
Conditions: Atrial Fibrillation|Epidemiology
Interventions: OTHER: The study does not have an intervention, but observe the AF incidence of the UK disease-free population
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: LAM-001 in Lung Transplant Recipients With Bronchiolitis Obliterans Syndrome.
Status: RECRUITING
Conditions: Bronchiolitis Obliterans Syndrome|Chronic Lung Allograft Dysfunction|Lung Transplantation
Interventions: DRUG: LAM-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Periodontitis Treatment on Quality of Life and Experiences of Fear, Anxiety and Pain
Status: COMPLETED
Conditions: Periodontitis
Interventions: PROCEDURE: Quadrant-wise scaling|PROCEDURE: Full-mouth 24-hour scaling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lumbar ESPB in Hip Replacement Surgery
Status: RECRUITING
Conditions: Coxarthrosis|Pain, Postoperative|Pain, Acute|Pain, Chronic|Postoperative Pain, Chronic|Analgesia|Quality of Life|Anesthesia|Spinal
Interventions: PROCEDURE: Spinal anesthesia|PROCEDURE: lumbar erector spinae plane block|PROCEDURE: Epidural analgesia|PROCEDURE: patient-controlled analgesia|DIAGNOSTIC_TEST: Timed Up and Go test|DIAGNOSTIC_TEST: neuropathic pain symptom inventory|DIAGNOSTIC_TEST: Lovett test|DIAGNOSTIC_TEST: Visual analog scale|DIAGNOSTIC_TEST: Quality of Recovery 40|DIAGNOSTIC_TEST: Ability to sit, stand upright, and walk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Chronic Kidney Disease Burden in an Underserved Population
Status: COMPLETED
Conditions: CKD|ESRD
Interventions: OTHER: Fruits and Vegetables|OTHER: Cooking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Therapy With Sulfamylon® 5% Topical Solution Compared to a Historical Control Group
Status: TERMINATED
Conditions: Burns
Interventions: DRUG: Sulfamylon® For 5 % Topical Solution|DRUG: Topical Antimicrobial/Antifungal Medications
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MEHD7945A and Cobimetinib in Patients With Locally Advanced or Metastatic Cancers With Mutant KRAS
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Cobimetinib|DRUG: MEHD7945A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Inspiratory Muscle Training in Pulmonary Hypertensive Patient
Status: COMPLETED
Conditions: Inspiratory Muscle Training
Interventions: OTHER: Deep Breathing Exercise|OTHER: Inspiratory muscle Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Conveen Optima Urisheaths With Collecting Bags Versus Absorbents
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: DEVICE: Conveen Optima is a urisheath to be used together with a collecting bag for urine|DEVICE: absorbent protection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myriad™ Augmented Soft Tissue Reconstruction Registry
Status: RECRUITING
Conditions: Abdominal Wound Dehiscence|Necrotizing Soft Tissue Infection|Lower Extremity Wound|Pilonidal Sinus|Anal Fistula|Hidradenitis Suppurativa|Pressure Injury
Interventions: DEVICE: Myriad Matrix™ and Myriad Morcells™
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Non-surgical Periodontal Treatment on HbA1c Levels in a Patient With Type 2 Diabetes Mellitus
Status: WITHDRAWN
Conditions: Chronic Periodontitis|Diabetes Mellitus, Type 2
Interventions: PROCEDURE: Non-surgical periodontal treatment: Scaling and root planing (SRP)|OTHER: Oral hygiene instructions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Vestibular Schwannoma
Status: SUSPENDED
Conditions: Vestibular Schwannoma
Interventions: DRUG: Bevacizumab (Avastin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating ABI-H0731 as Adjunctive Therapy in Participants With Chronic Hepatitis B Infection
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: ABI-H0731|DRUG: SOC NUC|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Zidovudine Plus Lamivudine Versus ddI Used Alone or in Combination With Zidovudine in HIV-1 Infected Children
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Lamivudine|DRUG: Zidovudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain
Status: RECRUITING
Conditions: Degenerative Disc Disease
Interventions: DRUG: Rexlemestrocel-L + HA mixture|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study in Japan of the Safety And Antiviral Activity in Adults With Chronic Hepatitis B Current Lamivudine Therapy
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine and Metabolic Outcomes in Patients Undergoing TPAIT
Status: COMPLETED
Conditions: Chronic Pancreatitis|Insulin Dependent Diabetes
Interventions: DRUG: Hydroxychloroquine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing Nutritional Status in Patients With Sepsis
Status: COMPLETED
Conditions: Malnutrition
Interventions: DIAGNOSTIC_TEST: NRS 2002, nutric, SGA and adductor pollicis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Electrocardiographic (ECG) Safety Study of Droxidopa at Clinical and Supratherapeutic Dose
Status: COMPLETED
Conditions: QTc Interval
Interventions: DRUG: Droxidopa|DRUG: Droxidopa|DRUG: Moxifloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: One- Versus Two-Stage Aesthetic Crown Lengthening
Status: COMPLETED
Conditions: Patients in Need of Surgical CL in the Anterior Maxillary Sextant for Restorative Purposes
Interventions: OTHER: Conventional Crown Lengthening (CCL)|OTHER: Two-stage Crown Lengthening (SCL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Satisfaction and Adaptation of Dentures Printed at 0 Versus 45 Degrees
Status: NOT_YET_RECRUITING
Conditions: Edentulous Jaw
Interventions: DEVICE: 0 degrees 3D printed upper complete dentures|DEVICE: 45 degrees 3D printed upper complete dentures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hemp Fiber Ingestion and Gut Permeability After Exercise
Status: RECRUITING
Conditions: Gastrointestinal Dysfunction|Metabolic Disturbance
Interventions: DIETARY_SUPPLEMENT: High Dose Hemp Fiber Bar|DIETARY_SUPPLEMENT: Low Dose Hemp Fiber Bar|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Radiation Therapy, Androgen Suppression, and Docetaxel in Treating Patients With High-Risk Prostate Cancer Who Have Undergone Radical Prostatectomy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: bicalutamide|DRUG: docetaxel|DRUG: flutamide|DRUG: LHRH agonist|RADIATION: 3-dimensional conformal radiation therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Budesonide in Babies (BiB) Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Bronchopulmonary Dysplasia (BPD)|Respiratory Distress Syndrome|Prematurity; Extreme|Neonatal
Interventions: DRUG: budesonide (Pulmicort nebulizing suspension).|DRUG: surfactant (poractant alfa;Curosurf)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarker Study After Initiation of Treatment With Fingolimod (FTY720) in Patients With Relapsing-remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing-remitting Multiple Sclerosis
Interventions: DRUG: Fingolimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of KHK 4323 in Healthy Volunteers and Subjects With Atopic Dermatitis
Status: TERMINATED
Conditions: Atopic Dermatitis
Interventions: DRUG: KHK4323 IV/S|DRUG: KHK4323 SC/S|DRUG: KHK4323 IV/M|DRUG: Placebo IV/S|DRUG: Placebo IV/M|DRUG: Placebo SC/S
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics and Efficacy Study of QCC374 in PAH Patients
Status: TERMINATED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: QCC374|DRUG: Placebo Matching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Effectiveness of JUVÉDERM VOLUMA® XC Injectable Gel for Cheek Augmentation Using Cannula
Status: COMPLETED
Conditions: Age-related Volume Deficit in the Mid-face
Interventions: DEVICE: JUVÉDERM VOLUMA® XC injectable gel with cannula|DEVICE: JUVÉDERM VOLUMA® XC injectable gel with needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Expression of Immune Checkpoint CD28 rs1980422-related Single-nucleotide Polymorphisms in the Primary Immune Thrombocytopenia
Status: UNKNOWN
Conditions: Immune Thrombocytopenia
Interventions: GENETIC: Genotyping of rs1980422-related single-nucleotide polymorphisms by real time PCR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Brain Connectivity and Response to Tai Chi in Geriatric Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: BEHAVIORAL: Tai-Chi-Chih (TCC)|BEHAVIORAL: Health Education and Wellness Classes (HEW)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Endoscopy Nurse Participation in Adenoma Detection Rate During Colonoscopy
Status: COMPLETED
Conditions: Polyp|Adenomatous Polyp|Colonoscopy
Interventions: PROCEDURE: standard of care colonoscopy|PROCEDURE: standard of care colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Preoperative Sarcopenia on Morbidity and Mortality in Patients Operated on From Digestive Cancers
Status: UNKNOWN
Conditions: Sarcopenia|Malnutrition|Pancreatic Cancer|Liver Cancer
Interventions: DEVICE: Assessment of sarcopenia by CT-Scan|DEVICE: hand gauge
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: To Assess Neuroinflammation and Neurocognitive Function in Patients With Acute Hepatitis C and Chronic HIV Co-Infection
Status: COMPLETED
Conditions: Acute Hepatitis C|HIV|HIV Infections
Interventions: OTHER: PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Optimization of OnabotulinumtoxinA (BTX-A) Injection for the Treatment of Neurogenic Lower Urinary Tract Dysfunction
Status: RECRUITING
Conditions: Neurogenic Bladder|Lower Urinary Tract Symptoms|Overactive Bladder|Neuro: Neurogenic Bladder|Neurogenic Detrusor Overactivity
Interventions: PROCEDURE: Standard number of injection sites|PROCEDURE: Reduced number of injection sites
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: To Assess the Effect of SCD-044 Treatment on Moderate to Severe Plaque Psoriasis
Status: RECRUITING
Conditions: Moderate to Severe Plaque Psoriasis
Interventions: DRUG: Placebo|DRUG: SCD-044_Dose 1|DRUG: SCD-044_Dose 2|DRUG: SCD-044_Dose 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat
Status: ACTIVE_NOT_RECRUITING
Conditions: Sickle Cell Disease|Hemolytic Anemia
Interventions: DRUG: Mitapivat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibrutinib in Combination With Lenalidomide and Rituximab in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Status: COMPLETED
Conditions: Relapsed Diffuse Large B-Cell Lymphoma|Refractory Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Ibrutinib|DRUG: Lenalidomide|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT