pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: JAB-21822 Activity in Adult Patients With Advanced Solid Tumors Harboring KRAS G12C Mutation
Status: RECRUITING
Conditions: Advanced Solid Tumor|NSCLC|CRC
Interventions: DRUG: JAB-21822 (KRAS G12C inhibitor)|DRUG: JAB-21822 (KRAS G12C inhibitor)|DRUG: JAB-21822 (KRAS G12C inhibitor)|DRUG: Cetuximab (EGFR inhibitor)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cilostazol Stroke Prevention Study for Antiplatelet Combination
Status: COMPLETED
Conditions: Noncardioembolic Cerebral Infarction
Interventions: DRUG: aspirin|DRUG: clopidogrel|DRUG: cilostazol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study Combining the Peposertib (M3814) Pill With Standard Chemotherapy in Patients With Ovarian Cancer With an Expansion in High Grade Serous Ovarian Cancer and Low Grade Serous Ovarian Cancer
Status: RECRUITING
Conditions: Endometrial High Grade Endometrioid Adenocarcinoma|Fallopian Tube Carcinosarcoma|Fallopian Tube Clear Cell Adenocarcinoma|Fallopian Tube Endometrioid Adenocarcinoma|Fallopian Tube High Grade Serous Adenocarcinoma|Fallopian Tube Mucinous Adenocarcinoma|Fallopian Tube Transitional Cell Carcinoma|Fallopian Tube Undifferentiated Carcinoma|FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma|FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma|Ovarian High Grade Serous Adenocarcinoma|Ovarian Seromucinous Carcinoma|Ovarian Undifferentiated Carcinoma|Platinum-Sensitive Ovarian Carcinoma|Primary Peritoneal Carcinosarcoma|Primary Peritoneal High Grade Serous Adenocarcinoma|Primary Peritoneal Transitional Cell Carcinoma|Primary Peritoneal Undifferentiated Carcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Low Grade Fallopian Tube Serous Adenocarcinoma|Recurrent Ovarian Carcinoma|Recurrent Ovarian Carcinosarcoma|Recurrent Ovarian Clear Cell Adenocarcinoma|Recurrent Ovarian Endometrioid Adenocarcinoma|Recurrent Ovarian Low Grade Serous Adenocarcinoma|Recurrent Ovarian Mucinous Adenocarcinoma|Recurrent Ovarian Transitional Cell Carcinoma|Recurrent Primary Peritoneal Carcinoma|Recurrent Primary Peritoneal Low Grade Serous Adenocarcinoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Echocardiography|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Multigated Acquisition Scan|DRUG: Pegylated Liposomal Doxorubicin Hydrochloride|DRUG: Peposertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aliskiren or Amlodipine in Hypertensive Hemodialysed Patients
Status: UNKNOWN
Conditions: Hypertension|Dialysis
Interventions: DRUG: Aliskiren
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Capecitabine and Cisplatin (XP)+Sorafenib in Advanced Gastric Cancer (AGC): Sorafenib+XP
Status: COMPLETED
Conditions: Advanced Gastric Cancer
Interventions: DRUG: Capecitabine, Cisplatin, Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Macronutrients in Lactating NICU Parents - Impact of Kangaroo Care
Status: RECRUITING
Conditions: Lactation Disorder With Baby Delivered|Nutrition Disorder, Infant
Interventions: BEHAVIORAL: Kangaroo Care|BEHAVIORAL: No Kangaroo Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparing the PrePex™ Device to Surgical MC for Rapid Scale Up of MC in Resource Limited Setting
Status: COMPLETED
Conditions: HIV
Interventions: DEVICE: PrePex™ device for adult male circumcision|PROCEDURE: Surgical circumcision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Advanced Imaging Holistic Omics Biobank
Status: NOT_YET_RECRUITING
Conditions: Oncologic Disorders|Neurologic Disorder|Pulmonary Disease|Cardiovascular Diseases
Interventions: RADIATION: Computed Tomography (CT) using Photon Counting CT scanner (Neaotom Alpha, Siemens) and Magnetic Resonance (MRI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunogenicity Trial of 3 Influenza Vaccines
Status: RECRUITING
Conditions: Influenza Vaccination
Interventions: BIOLOGICAL: Flublok Quadrivalent vaccine|BIOLOGICAL: Fluarix Quadrivalent vaccine|BIOLOGICAL: Flucelvax Quadrivalent vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: RELATIONSHIP OF LUMBOPELVIC MUSCULATURE WITH FUNCTIONAL TESTS IN NON-PROFESSIONAL ATHLETES WITH LUMBAR DISC HERNIATION
Status: UNKNOWN
Conditions: Low Back Pain|Herniated Lumbar Disk|Sciatica
Interventions: BEHAVIORAL: Questionnaires / scales|DIAGNOSTIC_TEST: Ultrasound imaging|DIAGNOSTIC_TEST: FLEXIBILITY|DIAGNOSTIC_TEST: FUNCTIONAL TESTS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Correlation Between HBA1c Level and Thickness of Both Macula and Choroid in Patients With Type 2 Diabetes Mellitus
Status: NOT_YET_RECRUITING
Conditions: Diabetic Retinopathy
Interventions: DEVICE: Swept Source Optical Coherence Tomography(Topcon DRI Triton)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase III Ganciclovir +/- rGM-CSF for AIDS-Related CMV Retinitis
Status: COMPLETED
Conditions: Cytomegalovirus Retinitis|HIV Infections
Interventions: DRUG: Sargramostim|DRUG: Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Innovative Device for Intravenous Administration
Status: UNKNOWN
Conditions: Safety Issues|Medical Device
Interventions: DEVICE: Drug administration and Flushing procedure using Double-Chamber Syringe|DEVICE: Drug administration and Flushing procedure using Classic Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Efficacy of Combined Intrathecal Morphine and PENG Block on Postoperative Pain in Hip Arthroplasty
Status: RECRUITING
Conditions: Postoperative Pain Management
Interventions: DRUG: Pericapsular nerve group block plus intrathecal bupivacaine|DRUG: Intrathecal bupivacaine and morphine|DRUG: Pericapsular nerve group block plus intrathecal bupivacaine and morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Daytime Sleepiness in Patients With the Assessment of a Sleep-related Respiratory Disorder
Status: UNKNOWN
Conditions: Sleep-related Respiratory Disorder
Interventions: OTHER: Questionnaire for recording daytime sleepiness over the course of the day|OTHER: Anamnesis and physicial examination|OTHER: Questionnaire for quantifying daytime sleepiness|DIAGNOSTIC_TEST: Pulmonary function test|DIAGNOSTIC_TEST: Polygraphy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Survivorship Care Planning in Improving Quality of Life in Survivors of Ovarian Cancer
Status: COMPLETED
Conditions: Cancer Survivor|Stage IA Ovarian Epithelial Cancer|Stage IB Ovarian Epithelial Cancer|Stage IC Ovarian Epithelial Cancer|Stage IIA Ovarian Epithelial Cancer|Stage IIB Ovarian Epithelial Cancer|Stage IIC Ovarian Epithelial Cancer|Stage IIIA Ovarian Epithelial Cancer|Stage IIIB Ovarian Epithelial Cancer|Stage IIIC Ovarian Epithelial Cancer
Interventions: OTHER: follow-up care|OTHER: active surveillance|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Investigate the Biological Effects of Saruparib (AZD5305), Darolutamide, and in Combination in Men With Newly Diagnosed Prostate Cancer.
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Saruparib (AZD5305)|DRUG: Darolutamide|OTHER: No Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Diurnal and Nocturnal Effect of Pilocarpine on Intraocular Pressure and Ocular Perfusion Pressure
Status: COMPLETED
Conditions: Glaucoma, Open-angle|Hypertension, Ocular
Interventions: DRUG: Pilocarpine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tele-PancFit: A Multi-site Trial of Video-based Strengthening Exercise Prehabilitation for Patients With Resectable Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: OTHER: Enhanced Usual Care|BEHAVIORAL: Tele-supervised resistance exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Toripalimab Therapy After Resection in High-risk Stage IA2-IB NSCLC With no Driver Alterations (EGFR or ALK)
Status: NOT_YET_RECRUITING
Conditions: NSCLC
Interventions: DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMRT Versus 3DCRT for Locally Advanced Rectal Cancer, Prospective Phase II Study.
Status: COMPLETED
Conditions: Rectal Cancer|Radiotherapy|Toxicity Due to Radiotherapy
Interventions: RADIATION: Intensive Modulated Radiation Therapy|RADIATION: 3-Dimension Conformal Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Encorafenib, Binimetinib and Cetuximab in Subjects With Previously Untreated BRAF-mutant ColoRectal Cancer
Status: COMPLETED
Conditions: BRAF V600E-mutant Metastatic Colorectal Cancer
Interventions: DRUG: encorafenib|DRUG: Binimetinib|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CONTOURA vs WFO Ablation PRK & LASIK
Status: RECRUITING
Conditions: Refractive Surgery
Interventions: DEVICE: Wave-Front Optimized (WFO) ablation vs Topography-guided (TG) ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Rheosorbilact® Solution for Infusion, in a Complex Therapy of Peritonitis
Status: COMPLETED
Conditions: Peritonitis|Intoxication
Interventions: DRUG: Rheosorbilact®|DRUG: Ringer lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeted Delivery of Chemotherapy With Ultrasound and Microbublles
Status: COMPLETED
Conditions: Colorectal Cancer|Hepatic Metastases
Interventions: RADIATION: MRI|RADIATION: Perfusion CT scan|OTHER: Contrast enhanced ultrasound|DRUG: Sonoporation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Diabetic Polyneuropathy
Status: RECRUITING
Conditions: Pain|Pain Syndrome|Pain, Chronic|Chronic Pain|Chronic Pain Syndrome|Diabetes|Diabetic Neuropathies|Diabetic Polyneuropathy|Peripheral Neuralgia|Peripheral Neuropathy|Peripheral Neuropathy With Type 2 Diabetis
Interventions: DRUG: Adezunap (AP707)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CSL312_3003 Safety and Pharmacokinetic Study in Subjects 2 to 11 Years of Age With Hereditary Angioedema
Status: RECRUITING
Conditions: Hereditary Angioedema (HAE)
Interventions: BIOLOGICAL: CSL312
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab, Paclitaxel, and Carboplatin in Patients With Advanced Stage Epithelial Ovarian Cancer (EOC).
Status: TERMINATED
Conditions: Fallopian Tube Cancer|Peritoneum Cancer|Epithelial Ovarian Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Physiotherapy Approaches in Patients With Subacromial Impingement Syndrome
Status: COMPLETED
Conditions: Subacromial Impingement Syndrome
Interventions: PROCEDURE: Proprioception exercises|PROCEDURE: Proprioception exercises with Electromyographic Biofeedback|PROCEDURE: Wand Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Association Between Delivered Oxygen and Cerebral Impact During the Use of Cardiopulmonary Bypass.
Status: RECRUITING
Conditions: Cardiac; Arteriosclerosis|Aortic Valve Disease
Interventions: DIAGNOSTIC_TEST: Cerebral injury markers|DIAGNOSTIC_TEST: Cerebral oximetry index
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Text-Based Messaging Strategies for Preventing Subsequent Problematic Alcohol Use
Status: RECRUITING
Conditions: Alcohol Drinking|Binge Drinking|Text Messaging
Interventions: BEHAVIORAL: Brief Alcohol Intervention|BEHAVIORAL: Automated and Targeted Text Messages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Oral Rabeprazole on the Prevention of Ulcer Bleeding Following Endoscopic Mucosal Resection
Status: COMPLETED
Conditions: Early Gastric Adenocarcinoma|Adenocarcinoma, Tubular
Interventions: DRUG: rabeprazole|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Manicaland PrEP Uptake Through Interactive Counselling Trial
Status: COMPLETED
Conditions: Improving Perceptions of HIV Risk|Improving Uptake of Pre-exposure Prophylaxis for HIV
Interventions: BEHAVIORAL: Interactive tablet-based quiz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Digital Cognitive Remote Training in Alzheimer's Disease (MA-EIAD)
Status: TERMINATED
Conditions: Alzheimer Disease
Interventions: BEHAVIORAL: Control - Cognitive training in a practitioner's office one time per week|BEHAVIORAL: Experimental group 1 - Cognitive training in a practitioner's office one time per week and cognitive distance training one time per week|BEHAVIORAL: Experimental group 2 - Cognitive training in a practitioner's office one time per week and cognitive distance training four times per week
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Fluorouracil in Treating Patients With Recurrent or Metastatic Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer|Transitional Cell Cancer of the Renal Pelvis and Ureter|Urethral Cancer
Interventions: DRUG: fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Myelofibrosis
Status: NOT_YET_RECRUITING
Conditions: Primary Myelofibrosis|Myelofibrosis; Primary Myelofibrosis; Post-polycythemia Vera Myelofibrosis; Post-essential Thrombocythemia Myelofibrosis
Interventions: DRUG: Momelotinib|DRUG: Luspatercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-Angiotensin II Type 1 Receptor Antibodies and Kidney Transplant Outcomes
Status: COMPLETED
Conditions: Kidney Transplant Failure and Rejection
Interventions: DIAGNOSTIC_TEST: Anti-angiotensin II type 1 receptor antibody measurement|DIAGNOSTIC_TEST: Measurement of ENDAT expression level allograft|OTHER: Allograft survival|OTHER: Allograft rejection appearance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Study of Recombinant Novel Coronavirus（COVID-19） Vaccine (CHO Cell) Combined With Influenza Vaccine
Status: COMPLETED
Conditions: Coronavirus Disease 2019
Interventions: BIOLOGICAL: Tetravalent influenza virus lysis vaccine|BIOLOGICAL: Recombinant new coronavirus vaccine (CHO cell) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Functional Magnetic Resonance Imaging of N-acetylcysteine in Cocaine Dependence
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DIETARY_SUPPLEMENT: N-acetylcysteine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of HINEX Jelly on Nutritional Status in People With Possible Sarcopenia or Sarcopenia
Status: ACTIVE_NOT_RECRUITING
Conditions: Sarcopenia
Interventions: DIETARY_SUPPLEMENT: HINEX Jelly ( jelly high protein supplement)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Rituximab to That of Calcineurin Inhibitors in Children With Steroid Resistant Nephrotic Syndrome
Status: UNKNOWN
Conditions: Nephrotic Syndrome
Interventions: DRUG: Rituximab|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Acceptability of the Darunavir/Cobicistat (DRV/COBI) Fixed-dose Combination (FDC) Tablet in Human Immunodeficiency Virus (HIV)-1 Infected Children
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV)
Interventions: DRUG: DRV/COBI FDC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Effects of 2 Diets in Veterans With the Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: MUFA MOVE! (Monounsaturated fatty enriched diet)|DIETARY_SUPPLEMENT: PUFA MOVE! (Polyunsaturated fatty acid enriched diet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Extraction Vs Non-extraction Orthodontic Treatment on Vertical Facial Dimension
Status: UNKNOWN
Conditions: Malocclusion|Long Face Syndrome|Crowding, Tooth
Interventions: DEVICE: Extraction orthodontic treatment|DEVICE: Non-extraction orthodontic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Associating Liver Partition With Portal Vein Ligation For Staged Hepatectomy (ALPPS) or Portal Vein Occlusion in Treating Patients With Liver Cancer
Status: WITHDRAWN
Conditions: Carcinoma, Hepatocellular
Interventions: PROCEDURE: ALPPS surgery|PROCEDURE: PVO surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Poststroke Depression in Hemorrhagic Stroke
Status: RECRUITING
Conditions: Stroke Hemorrhagic|Depression
Interventions: DRUG: Fluoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Multi-Center, Randomized, Open-Label Study of G/P +/- RBV for NS5A + SOF Previously Treated GT1 HCV Subjects
Status: COMPLETED
Conditions: Hepatitis C|HCV
Interventions: DRUG: Glecaprevir/Pibrentasvir (G/P) 300mg/120mg|DRUG: Ribavirin 200Mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ursodeoxycholic Acid Combined With Total Glucosides of Paeony in the Treatment of PBC With AIH Features 1
Status: UNKNOWN
Conditions: Hepatitis|Primary Biliary Cholangitis|Autoimmune
Interventions: DRUG: Ursodeoxycholic acid combined with total glucosides of paeony|DRUG: Ursodeoxycholic acid only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of L/A Spray andL/A-soaked Nasal Packings on Postoperative Pain After Nasal Closed Reduction
Status: COMPLETED
Conditions: Nasal Fracture
Interventions: DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Home-based Orofacial Exercise Program on Oral Aperture of Systemic Sclerosis Patients
Status: COMPLETED
Conditions: Microstomia|Systemic Sclerosis
Interventions: OTHER: orofacial exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Patching-Atropine for Residual Amblyopia
Status: TERMINATED
Conditions: Amblyopia
Interventions: DEVICE: Patching|DRUG: Atropine|DEVICE: Patching|DRUG: Atropine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact on the Use of Antibiotics of a Multimodal Algorithm for the Diagnosis and Management of Acute Community-acquired Pneumonia in the Emergency Room
Status: ACTIVE_NOT_RECRUITING
Conditions: Community-acquired Pneumonia
Interventions: DIAGNOSTIC_TEST: CRP dosage|DIAGNOSTIC_TEST: multiplex PCR|DIAGNOSTIC_TEST: chest scan without injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Clinical Efficacy of Y-STRUT® Medical Device Implanted for Contralateral Percutaneous Internal Fixation of Proximal Femur, in Patient With a Low Energy Per Trochanteric Fracture on the First Side
Status: TERMINATED
Conditions: Fracture of Hip|Osteoporosis
Interventions: DEVICE: Y-STRUT® (Hyprevention, Pessac, France)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Different Pancreaticojejunostomy After Pancreaticoduodenectomy
Status: RECRUITING
Conditions: Pancreaticoduodenectomy|Postoperative Pancreatic Fistula
Interventions: PROCEDURE: pancreaticojejunostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NK Cells as Consolidation Therapy of Acute Myeloid Leukemia in Children/Adolescents
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Leukemia|Myeloid Leukemia
Interventions: DRUG: cyclophosphamide|DRUG: Fludarabine|PROCEDURE: NK cell infusion|DRUG: IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PTCy and Ruxolitinib GVHD Prophylaxis in Myelofibrosis
Status: COMPLETED
Conditions: Primary Myelofibrosis|Myeloproliferative Disorders
Interventions: PROCEDURE: Allogeneic hematopoietic stem cell transplantation|DRUG: Busulfan|DRUG: Fludarabine monophosphate|DRUG: Cyclophosphamide|DRUG: Ruxolitinib|DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of IMC-A12 or Ramucirumab Plus Mitoxantrone and Prednisone in Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: IMC-A12|DRUG: Mitoxantrone|DRUG: Prednisone|BIOLOGICAL: IMC-1121B (ramucirumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Monitoring During Craniosynostosis Surgery: Comparing Traditional and Newer Technology Monitors (CRASY-PRAM)
Status: RECRUITING
Conditions: Craniosynostoses|Hypovolemia|Hemorrhage|Hemodynamic Instability
Interventions: PROCEDURE: Intraoperative monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comparison of Techniques for Treating Skin Abscesses
Status: COMPLETED
Conditions: Cutaneous Abscess
Interventions: PROCEDURE: Incision and Drainage with packing (wick) placement|PROCEDURE: Abscess drainage with loop placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intermittent Pneumatic Compression With and Without Exercise to Improve Functioning in Peripheral Artery Disease
Status: RECRUITING
Conditions: Peripheral Artery Disease
Interventions: DEVICE: intermittent pneumatic compression|BEHAVIORAL: exercise|DEVICE: Sham device|BEHAVIORAL: Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Palbociclib With Cisplatin or Carboplatin in Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Neoplasm|Stage III Pancreatic Cancer|Stage IIIA Breast Cancer|Stage IIIA Non-Small Cell Lung Cancer|Stage IIIB Breast Cancer|Stage IIIB Non-Small Cell Lung Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer|Stage IV Non-Small Cell Lung Cancer|Stage IVA Pancreatic Cancer|Stage IVB Pancreatic Cancer|Sarcoma|Colorectal Cancer|Head and Neck Cancer|Cancer of Unknown Primary|Bladder Cancer|Ovarian Cancer
Interventions: DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azacitidine and Enasidenib in Treating Patients With IDH2-Mutant Myelodysplastic Syndrome
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Blasts 20-30 Percent of Bone Marrow Nucleated Cells|Chronic Myelomonocytic Leukemia|IDH2 Gene Mutation|Myelodysplastic Syndrome With Excess Blasts|Recurrent High Risk Myelodysplastic Syndrome|Refractory High Risk Myelodysplastic Syndrome
Interventions: DRUG: Azacitidine|DRUG: Enasidenib|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influences of High-fiber, Organic Whole-food Formula on the Gut Microbiome in Critically Ill Children
Status: RECRUITING
Conditions: Critical Illness|Dysbiosis|Pediatric ALL
Interventions: OTHER: Nourish|OTHER: Pediasure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Investigating Cognitive Impairment in Young Patients With Cancer Prospectively
Status: RECRUITING
Conditions: Chemotherapy-Related Cognitive Impairment|Chemotherapeutic Toxicity|Chemo-brain|Cancer|Childhood Cancer|Hodgkin Lymphoma|Non Hodgkin Lymphoma|Testicular Cancer|Sarcoma|Leukemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of In-Person Versus Remote Cochlear Implant Candidacy Evaluations
Status: COMPLETED
Conditions: Hearing Loss|Hearing Disorders
Interventions: DEVICE: Remote CI Counseling|OTHER: In-Person CI Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial to Evaluate Steady State Pharmacokinetic Parameters, Efficacy and Safety of Nevirapine in Antiretroviral Drug naïve Pediatric Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Nevirapine|DRUG: Lamivudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sentinel Lymph Node Biopsy Findings in Patients With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Lymphoseek|DRUG: Sulfur Colloid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Effects of the New Program for Cognitive Enhancement and Improvement in the Elderly
Status: COMPLETED
Conditions: Aging
Interventions: OTHER: Cognitive rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Guided Imagery & Music in Cancer
Status: UNKNOWN
Conditions: Cancer, Breast|Cancer, Metastatic|Cancer Ovaries|Cancer Uterus Cervix
Interventions: BEHAVIORAL: the Guided Imagery and Music method|BEHAVIORAL: standard care and verbal counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I Study of the Safety and Pharmacokinetics of Recombinant Human CD4 Immunoglobulin (rCd4-IgG) Administered by Intravenous Bolus in Patients With AIDS and AIDS Related Complex
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: CD4-IgG
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Clinical Trial of Rituxan and B-Glucan PGG in Relapsed Indolent Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Relapsed/Refractory Indolent B Cell Non-Hodgkin Lymphomas
Interventions: DRUG: Imprime PGG|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prebiotics and Metformin Improve Gut and Hormones in Type 2 Diabetes in Youth (MIGHTY-fiber)
Status: COMPLETED
Conditions: Diabetes
Interventions: DIETARY_SUPPLEMENT: Biomebliss|DRUG: Metformin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Fentanyl to Reduce the Time of Severe Postoperative Pain Relief Compared to Morphine
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Fentanyl|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Arm Trial With Resolute Onyx in ONE-Month DAPT for High-Bleeding Risk Patients Who Are Considered One-Month Clear (Onyx ONE Clear)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: COMBINATION_PRODUCT: Device: Medtronic Resolute Onyx Zotarolimus-Eluting Coronary Stent System Treatment Followed by one-month DAPT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Relative Bioavailability of 3 Indacaterol/Glycopyrronium Test Products and Reference Product
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Indacaterol/glycopyrronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Linagliptin on Endothelial- , Renal-, and Retinal Function in Patients With Hypertension and Albuminuria
Status: COMPLETED
Conditions: Arterial Hypertension|Albuminuria
Interventions: DRUG: Linagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Trial of Cadonilimab With Adriamycin in Patients With Advanced Soft Tissue Sarcoma
Status: NOT_YET_RECRUITING
Conditions: Advanced Soft-tissue Sarcoma
Interventions: DRUG: Cadonilimab|DRUG: Adriamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Naked Eye 3D Vision Training for the Prevention and Control of Myopia in Adolescents and Children
Status: UNKNOWN
Conditions: Adolescents and Children|Axial Elongation|Naked Eye 3D Vision Training|Visual Function
Interventions: BEHAVIORAL: Naked eye 3D vision training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluating Efficacy and Safety of Anlotinib Combined With Concurrent Chemoradiotherapy Followed by Consolidation Immunotherapy for Locally Advanced Non-small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Locally Advanced Non-small Cell Lung Cancer|Efficacy and Safety
Interventions: DRUG: Anlotinib|DRUG: Chemotherapy|RADIATION: Radiotherapy|DRUG: Immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Demographic Parameters and ACL Injury on the Association Among Clinical, Functional and Biomechanical Parameters
Status: RECRUITING
Conditions: Anterior Cruciate Ligament (ACL) Injury
Interventions: OTHER: Data collection (demographic, clinical, functional and biomechanical outcomes in patients after ACL injury (conservative therapy and/or surgery) in patients of different ages and healthy controls)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Safety and Efficacy of an Extravascular, Water-Soluble Sealant for Venous Access-Site Closure
Status: COMPLETED
Conditions: Cardiac Diagnostic Procedure|Cardiac Interventional Procedure|Femoral Access Site Closure
Interventions: DEVICE: Mynx Vascular Closure System|OTHER: Manual Compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Aerobic Training and Weight Loss on Skeletal Muscle Inflammatory Markers and Muscle Protein Balance in Older Adults
Status: UNKNOWN
Conditions: Overweight and Obesity|Inflammation; Muscle|Sedentary Lifestyle
Interventions: BEHAVIORAL: Diet-Induced Weight Loss|BEHAVIORAL: Aerobic Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: MGTA-145 + Plerixafor in the Mobilization of HSCs for Allogeneic Transplant in Hematologic Malignancies
Status: TERMINATED
Conditions: Related Donors Donating PBSC to a Family Member|Healthy Donors|Acute Myelogenous Leukemia|Acute Lymphoblastic Leukemia|Myelodysplastic Syndrome
Interventions: BIOLOGICAL: MGTA-145|BIOLOGICAL: Plerixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of a Paper and Automated Bladder Diary in Pediatric Patients
Status: RECRUITING
Conditions: Lower Urinary Tract Symptoms|Voiding Disorders|Enuresis|Overactive Bladder
Interventions: DEVICE: Minze Diary Pod|OTHER: Paper bladder diary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases
Status: UNKNOWN
Conditions: Other Specified Inflammatory Disorders of Skin or Subcutaneous Tissue|Pyoderma Gangrenosum|Erosive Pustular Dermatosis of the Scalp|Sweet's Syndrome|Behcet's Disease|Bowel-associated Dermatosis-arthritis Syndrome|Pustular Psoriasis|Acute Generalized Exanthematous Pustulosis|Keratoderma Blenorrhagicum|Sneddon-Wilkinson Disease|IgA Pemphigus|Amicrobial Pustulosis of the Folds|Infantile Acropustulosis|Transient Neonatal Pustulosis|Neutrophilic Eccrine Hidradenitis|Rheumatoid Neutrophilic Dermatitis|Neutrophilic Urticaria|Still's Disease|Erythema Marginatum|Unclassified Periodic Fever Syndromes / Autoinflammatory Syndromes|Dermatitis Herpetiformis|Linear IgA Bullous Dermatosis|Bullous Systemic Lupus Erythematosus|Inflammatory Epidermolysis Bullosa Aquisita|Neutrophilic Dermatosis of the Dorsal Hands (Pustular Vasculitis)|Small Vessel Vasculitis Including Urticarial Vasculitis|Erythema Elevatum Diutinum|Medium Vessel Vasculitis
Interventions: PROCEDURE: Collection of biological samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Collabri Flex - Effect of Collaborative Care for People With Anxiety Disorders in General Practice
Status: COMPLETED
Conditions: Panic Disorder|Generalized Anxiety Disorder|Social Phobia|Obsessive-Compulsive Disorder|Post Traumatic Stress Disorder|Agoraphobia
Interventions: BEHAVIORAL: Collaborative care|BEHAVIORAL: Consultations-Liaison
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Ursodeoxycholic Acid in Liver Functional Restoration of Patients With Obstructive Jaundice
Status: UNKNOWN
Conditions: Obstructive Jaundice
Interventions: DRUG: Ursodeoxycholic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cyanoacrylate With Sutures for Fixation of Free Gingival Graft
Status: UNKNOWN
Conditions: Soft Tissue Atrophy
Interventions: DRUG: cyanoacrylate tissue adhesive beside sutures
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Is Kinesio Taping Application Effective on Decreasing Injury Risk for Tennis Players
Status: COMPLETED
Conditions: Injury
Interventions: OTHER: Kinesio Taping (Performance Plus)|OTHER: Kinesio taping (Gold Tex)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Safety and Immunogenicity of a Malaria Vaccine Candidate, R21, Administered With AS01B
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: R21 with ASO1B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial to Determine Which of Two Surgical Techniques Works Better to Correct Vaginal Bulging
Status: UNKNOWN
Conditions: Rectocele
Interventions: PROCEDURE: Insertion of pelvicol graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Task-specific Training for Patients With Acute Exacerbation of COPD
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: BEHAVIORAL: Task-specific training|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of BMS-833923 With Carboplatin and Etoposide Followed by BMS-833923 Alone in Subjects With Extensive-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Small Cell Lung Carcinoma
Interventions: DRUG: BMS-833923|DRUG: Carboplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Once or Twice Daily Mometasone Nasal Spray Versus Amoxicillin Versus Placebo for Treatment of Acute Rhinosinusitis (Phase 3 Study)(Study P02692)
Status: COMPLETED
Conditions: Acute Rhinosinusitis
Interventions: DRUG: mometasone furoate nasal spray (MFNS)|DRUG: MFNS|DRUG: Amoxicillin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of JDQ443 in Comparison With Docetaxel in Participants With Locally Advanced or Metastatic KRAS G12C Mutant Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: JDQ443|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pomalidomide and Dexamethasone With or Without Ixazomib in Treating Patients With Relapsed Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma in Relapse
Interventions: DRUG: pomalidomide|DRUG: ixazomib|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Direct and Spillover Impacts of a Community-Level HIV/AIDS Program
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: BEHAVIORAL: FCC (Força à Comunidade e Crianças) program- direct beneficiary|BEHAVIORAL: FCC (Força à Comunidade e Crianças) program- non-direct beneficiary|BEHAVIORAL: Anti Stigma Information|BEHAVIORAL: HIV/AIDS Information|BEHAVIORAL: ART Information|BEHAVIORAL: HIV/AIDS and ART Information Combined|BEHAVIORAL: High coupon value
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Very Low-calorie Diet Versus Bariatric Surgery on Body Composition and Gut Microbiota Pattern
Status: ENROLLING_BY_INVITATION
Conditions: Obesity
Interventions: OTHER: Very low-calorie diet|PROCEDURE: Bariatric surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Relative Bioavailability and Food Effect of GDC-9545 in Healthy Females of Non-Childbearing Potential
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: GDC-9545 Tablet, Fasted: Treatment A|DRUG: GDC-9545 Capsule, Fasted: Treatment B|DRUG: GDC-9545 Capsule, Fed: Treatment C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of taVNS on Heart Rate in Persistent Atrial Fibrillation
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation, Persistent
Interventions: DEVICE: active taVNS|DEVICE: sham-taVNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Resistant Starch and Satiety
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DIETARY_SUPPLEMENT: Placebo- Fiber free control|DIETARY_SUPPLEMENT: Hi-maize resistant starch 9g|DIETARY_SUPPLEMENT: Novalose 330 resistant starch 9g|DIETARY_SUPPLEMENT: 4.5g Hi-maize resistant starch and 4.5g Novalose 330
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lung Ultrasound for the Detection of Pulmonary Atelectasis in the Perioperative Period
Status: ACTIVE_NOT_RECRUITING
Conditions: Postoperative Pulmonary Atelectases
Interventions: DEVICE: Ultrasound of the lungs|DEVICE: Electric impedance tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Biophysical Impact of Transcutaneous Spinal Cord Stimulation Within a Single Session
Status: WITHDRAWN
Conditions: Spinal Cord Injuries
Interventions: OTHER: Transcutaneous Spinal Cord Stimulation|OTHER: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of CUSA-081 in the Restoration of Central Venous Access Device (CVAD) Functionality
Status: TERMINATED
Conditions: Catheter Occlusion|Thrombosis
Interventions: DRUG: CUSA-081|DRUG: Placebo|DRUG: Alteplase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Cabozantinib as a Maintenance Agent to Prevent Progression or Recurrence in High-Risk Pediatric Solid Tumors
Status: RECRUITING
Conditions: Neuroblastoma|Sarcoma
Interventions: DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metachronic Brain Metastases After Esophagectomy for Esophageal Cancer (METABREC)
Status: RECRUITING
Conditions: Esophageal Neoplasms|Esophagectomy|Brain Metastases
Interventions: PROCEDURE: Esophagectomy for esophageal cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Heart Rate Variability Under Propofol and Sevoflurane
Status: COMPLETED
Conditions: General Anesthesia
Interventions: DRUG: Sevoflurane|DRUG: Propofol|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: CAR-T CD19 for Acute Myelogenous Leukemia With t 8:21 and CD19 Expression
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: CAR-T CD19
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Digital Patient-Reported Outcomes Tool for Diabetes Management
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes
Interventions: OTHER: Mobile Health (mHealth) Patient-Reported Outcome (PRO) tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonadotropin (hCG) in Adolescent Males With Hypogonadotropic Hypogonadism (HH) (MK-8962-043)
Status: COMPLETED
Conditions: Hypogonadotropic Hypogonadism
Interventions: DRUG: Corifollitropin alfa|DRUG: hCG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effective Effect-Site Propofol Concentration for Induction and Intubation for Schnider Model in Parturients
Status: UNKNOWN
Conditions: C.Delivery; Surgery (Previous), Gynecological
Interventions: DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT