pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies
Status: RECRUITING
Conditions: Epithelial Ovarian Cancer|Gastric Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma|Urothelial Carcinoma|Non-Small Cell Lung Cancer|Small-Cell Lung Cancer|Endometrial Carcinoma|Head and Neck Squamous Cell Carcinoma|Breast Cancer
Interventions: DRUG: SKB264
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bezlotoxumab as Secondary Prophylaxis for C. Difficile in High-risk Hospitalized Patients Exposed to Antibiotics.
Status: TERMINATED
Conditions: Clostridium Difficile
Interventions: DRUG: Bezlotoxumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Subject Preference for Scalp Psoriasis Treatment
Status: COMPLETED
Conditions: Scalp Psoriasis
Interventions: DRUG: C. propionate - Corticosteroid 1|DRUG: C. propionate- Corticosteroid 2|DRUG: C. propionate -Corticosteroid 3|DRUG: Corticosteroid 1- C. propionate|DRUG: Corticosteroid 2 - C. propionate|DRUG: Corticosteroid 3 - C. propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Periocular Rejuvenation by Topical Hyaluronic Acid Nano Particles
Status: RECRUITING
Conditions: Tear Trough Eyelid Deformity|Dark Eyelids|Wrinkle
Interventions: DRUG: Hyaluronic acid NanoGel|DRUG: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Adjunctive EndoAnchors for EVAR and TEVAR
Status: UNKNOWN
Conditions: Aortic Aneurysm|Thoracic Aortic Aneurysm
Interventions: DEVICE: ESAR (Endosutured Aneurysm Repair)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: UPenn Observational Research Repository on Neurodegenerative Disease
Status: RECRUITING
Conditions: Frontotemporal Degeneration(FTD)|Primary Progressive Aphasia(PPA)|Familial Frontotemporal Lobar Degeneration (fFTLD)|Amyotrophic Lateral Sclerosis(ALS)|Lewy Body Disease(LBD)|Progressive Supranuclear Palsy(PSP)|Corticobasal Syndrome(CBS)|Posterior Cortical Atrophy(PCA)|Alzheimer's Disease(AD)
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Motivational Interviewing on the Level of Self-Efficacy and Addiction in Smoking Cessation
Status: COMPLETED
Conditions: Quit Smoking
Interventions: OTHER: motivational interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pulmonary Hypertension and Anastrozole Trial
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Anastrozole|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maintenance Pembrolizumab at Usual or Low doSE in Non-squamous Lung Cancer: a Non-inferiority Study
Status: RECRUITING
Conditions: Metastatic Non-squamous Lung Cancer
Interventions: DRUG: Pembrolizumab 200 mg Q6W|DRUG: Pemetrexed 500 mg/m^2 Q3W|DRUG: Pembrolizumab 200 mg Q3W or 400 mg Q6W
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label, Multicenter Study to Evaluate the Efficacy and Safety of Transitioning to Lemborexant in Japanese Subjects With Insomnia
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: Lemborexant (LEM) 5 mg (Z-Drug-mono cohort)|DRUG: Lemborexant (LEM) 5 mg (SUV-mono cohort)|DRUG: Lemborexant (LEM) 5 mg (SUV-combination cohort)|DRUG: Lemborexant (LEM) 5 mg (RMT-combination cohort)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serial Analysis of Chimerism in Patients With Refractory Cytopenia (RC) Transplanted With Reduced Intensity Conditioning (RIC)
Status: COMPLETED
Conditions: Refractory Cytopenia of Childhood|Reduced Intensity Conditioning (RIC)|Myelodysplastic Syndrome (MDS)|Hematopoietic Stem Cell Transplantation (SCT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial to Evaluate the Safety and Efficacy of Maraviroc in Patients Hospitalized for Coronavirus Disease 2019 (COVID-19)
Status: COMPLETED
Conditions: Virus Diseases
Interventions: DRUG: Maraviroc experimental group|OTHER: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy With or Without Gemtuzumab Ozogamicin in Treating Older Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: cytarabine|DRUG: etoposide|DRUG: gemtuzumab ozogamicin|DRUG: idarubicin|DRUG: mitoxantrone hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plasma Rich in Growth Factors (PRGF-Endoret) in the Regeneration of Post-Extraction Sockets
Status: COMPLETED
Conditions: Post-Extraction Sockets Healing
Interventions: BIOLOGICAL: Plasma Rich in Growth Factors PRGF-Endoret|PROCEDURE: Conventional closure of the lesion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Trial of the Combination of Alpha-Lipoic Acid and Mirabegron in Women and in Men With Obesity
Status: NOT_YET_RECRUITING
Conditions: Insulin Resistance|Obesity
Interventions: DRUG: Placebo|DRUG: Mirabegron|DRUG: Alpha-lipoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Vigiis 101 Lactic Acid Bacteria Powder on Body Weight and Body Fat in Overweight Participants
Status: RECRUITING
Conditions: Body Weight|Body Fat|Overweight
Interventions: DIETARY_SUPPLEMENT: Vigiis 101 Lactobacillus Capsules|DIETARY_SUPPLEMENT: Placebo Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Proof-of-concept Study Evaluating Subcutaneous Amlitelimab in Adult Participants With Moderate to Severe Hidradenitis Suppurativa
Status: RECRUITING
Conditions: Hidradenitis
Interventions: DRUG: Amlitelimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PROductivity Study of Presbyopia Elimination in Rural-dwellers (PROSPER)
Status: COMPLETED
Conditions: Presbyopia
Interventions: OTHER: Intervention group|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Trial to Demonstrate the Safety and Performance of REGENERA Breast Implant in 40-70 Years Old Women Affected by Malignant Breast Lesion Treated by Lumpectomy
Status: RECRUITING
Conditions: Mastectomy, Segmental|Breast Neoplasm Malignant Female
Interventions: DEVICE: REGENERA breast implant implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: AFP464 in Treating Patients With Metastatic or Refractory Solid Tumors That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Male Breast Cancer|Recurrent Breast Cancer|Recurrent Ovarian Epithelial Cancer|Recurrent Primary Peritoneal Cavity Cancer|Recurrent Renal Cell Cancer|Stage IV Breast Cancer|Stage IV Ovarian Epithelial Cancer|Stage IV Primary Peritoneal Cavity Cancer|Stage IV Renal Cell Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: AFP464|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted Active Case Detection Among High Risk Populations in Southern Lao Peoples Democratic Republic
Status: COMPLETED
Conditions: Plasmodium Falciparum Malaria
Interventions: DIAGNOSTIC_TEST: Standard RDT and HS-RDT|DIAGNOSTIC_TEST: Standard RDT and HS-RDT|DRUG: Artemether-lumefantrine|DRUG: Primaquine Phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: FOLFIRINOX Versus OncoSil™ in Addition to FOLFIRINOX in Patients With Locally Advanced Pancreatic Adenocarcinoma
Status: RECRUITING
Conditions: Locally Advanced Pancreatic Cancer
Interventions: DRUG: FOLFIRINOX chemotherapy|DEVICE: OncoSil™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bryophyllum Pinnatum Treatment of Anxiety Related to Signs of Preterm Birth
Status: TERMINATED
Conditions: Preterm Labor|Anxiety
Interventions: DRUG: Bryophyllum 50% chewable tablets|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Peptide Vaccine for Glioblastoma Against Cytomegalovirus Antigens
Status: WITHDRAWN
Conditions: Glioblastoma
Interventions: BIOLOGICAL: PEP-CMV|BIOLOGICAL: PEP-CMV|BIOLOGICAL: PEP-CMV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of the Administration of Local Anesthetics Via Two Catheters Placed During Surgery, and Study of the Benefits on Respiratory Function and Therefore on Recovery Time
Status: RECRUITING
Conditions: Duration of Hospitalization in Intensive Care Unit
Interventions: PROCEDURE: multi-perforated catheter|PROCEDURE: Classic procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Peak(R) vs. Electrocautery in Children Undergoing Tonsillectomy With Adenoidectomy
Status: COMPLETED
Conditions: Sleep Disordered Breathing
Interventions: DEVICE: PEAK® Plasma System|DEVICE: Electrosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Economic Benefits of Cardiovascular Risk Management by a Dietician in Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Type 1 Diabetes|Type 2 Diabetes
Interventions: BEHAVIORAL: Intensive treatment|OTHER: Normal follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Transplantation With NiCord® (Omidubicel) vs Standard UCB in Patients With Leukemia, Lymphoma, and MDS
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematological Malignancies|Acute Lymphoblastic Leukemia (ALL)|Acute Myelogenous Leukemia (AML)|Chronic Myelogenous Leukemia (CML)|Myelodysplastic Syndrome (MDS)|Lymphoma|Acute Leukemia
Interventions: DRUG: NiCord® (omidubicel)|OTHER: Cord Blood Unit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Celecoxib Versus Naproxen in the 6-month Treatment of Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Celecoxib|DRUG: Naproxen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Center Randomized Controlled Study on the Promotion of Rapid Recovery
Status: RECRUITING
Conditions: Nonfunctional Adrenal Cortex Adenoma|Primary Aldosteronism|Cushing Syndrome
Interventions: PROCEDURE: Tubeless laparoscopic adrenalectomy|PROCEDURE: Drainage tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PanACEA - STEP2C -01
Status: RECRUITING
Conditions: Pulmonary Tuberculosis|Other Specified Pulmonary Tuberculosis
Interventions: DRUG: BTZ-043|DRUG: Rifampicin|DRUG: Isoniazid|DRUG: Pyrazinamide|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study Evaluating the Safety and Efficacy of SI-614 Ophthalmic Solution in Patients With Dry Eye
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: High concentration SI-614|DRUG: Low concentration SI-614|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Antihistaminic in Acute Renal Colic Prevent Pain Recurrence and Expulsion of Ureteric Stone ≤ 1cm
Status: UNKNOWN
Conditions: Renal Colic|Ureter Stone
Interventions: DRUG: Tamsulosin Hcl 0.4Mg Cap|DRUG: fexofenadine 180 mg Oral tablet
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Timely Nudge About Lab Results to Increase myGeisinger Uptake
Status: COMPLETED
Conditions: Telehealth|Health Behavior
Interventions: BEHAVIORAL: Timely|BEHAVIORAL: Transparency|BEHAVIORAL: Foot-in-the-door
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Imatinib for Multiple Sclerosis (MS) Relapses
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: DRUG: Imatinib Mesylate|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Teneteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-Ⅳ(TRACE Ⅳ)
Status: RECRUITING
Conditions: Tenecteplase|Minor Ischemic Stroke
Interventions: DRUG: rhTNK-tPA|DRUG: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 8-Week PK/PD Atorvastatin Study In Children And Adolescents With Heterozygous Familial Hypercholesterolemia
Status: COMPLETED
Conditions: Pediatric Heterozygous Hypercholesterolemia
Interventions: DRUG: Atorvastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Electro-Magnetic Convulsive Therapies for Depression: a Non-inferiority Study
Status: RECRUITING
Conditions: Major Depressive Disorder|Bipolar Depression
Interventions: DEVICE: Magnetic Seizure Therapy|DEVICE: Electroconvulsive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Alpha Blocker Monotherapy and 5ARI Monotherapy Following Combination Therapy in Benign Prostatic Hyperplasia (BPH)
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: combination therapy|DRUG: alpha blocker monotherapy|DRUG: 5 alpha reductase inhibitor monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mayo Clinic Traumatic Brain Injury Model System Center: The CONNECT Trial
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: OTHER: Complex clinical intervention|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Intraoperative Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) With Cisplatin to Treat Platinum-sensitive Recurrent Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: PROCEDURE: Cisplatin administered intraoperatively as hyperthermic intraperitoneal chemoperfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality: Influence on Satisfaction, Pain, and Anxiety in Patients Undergoing Colposcopy
Status: COMPLETED
Conditions: Cervical Dysplasia|Pain|Anxiety
Interventions: DEVICE: Virtual reality headset before colposcopy|DEVICE: Virtual reality headset during colposcopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Developing and Testing an Online Intervention for Alcohol and Cannabis Misuse and Healthy Relationship Skills Among Young Adult Couples
Status: NOT_YET_RECRUITING
Conditions: Alcohol Drinking|Cannabis Use|Couples
Interventions: BEHAVIORAL: Online, couples-based intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: MiMi: A Randomized Trial of Mifepristone and Misoprostol for Treatment of Early Pregnancy Failure
Status: TERMINATED
Conditions: Early Pregnancy Failure|Miscarriage|Fetal Demise|Anembryonic Pregnancy
Interventions: DRUG: Misoprostol and placebo|DRUG: Mifepristone and misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing Better Bottles for Babies
Status: NOT_YET_RECRUITING
Conditions: Pediatric Obesity|Weight Gain Trajectory|Infant Obesity
Interventions: BEHAVIORAL: Small Bottle Size|BEHAVIORAL: Standard Bottle Size|BEHAVIORAL: Clear Bottle|BEHAVIORAL: Opaque Bottle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CRT-Guanfacine for SPD
Status: COMPLETED
Conditions: Schizotypal Personality Disorder|SPD
Interventions: BEHAVIORAL: Cognitive Remediation Therapy|DRUG: Guanfacine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Vibrant Capsule on Gastric Emptying and Antropyloroduodenal Motility in Healthy Volunteers
Status: COMPLETED
Conditions: Gastroparesis
Interventions: DEVICE: Sham vibrating capsule|DEVICE: Vibrant Capsule (1 vibration)|DEVICE: Vibrant Capsule (3 vibration)|DEVICE: Vibrant Capsule (5 vibration)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Single Dose Study of Debio 1450 in Healthy Subjects
Status: COMPLETED
Conditions: Bacterial Infections
Interventions: DRUG: Debio 1450|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Investigation of the Pharmacokinetics of GSK961081 and Fluticasone Propionate in Healthy Volunteers
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK961081 800 microgram dose|DRUG: Fluticasone Propionate 500 microgram dose|DRUG: GSK961081 800 microgram and Fluticasone Propionate 500 microgram separately|DRUG: GSK961081 800 microgram Fluticasone Propionate 500 microgram in a blend
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ixabepilone and SBRT For Metastatic Breast Cancer
Status: WITHDRAWN
Conditions: METASTATIC BREAST CANCER
Interventions: DRUG: IXABEPILONE|RADIATION: STEREOTACTIC BODY RADIATION THERAPY
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HAIC or Lenvatinib Combined With Sintilimab for High Recurrence Risk Resectable Solitary Hepatocellular Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: HAIC|DRUG: Sintilimab|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Study to Evaluate Safety and Efficacy of QL-007 Tablets in Combination With Tenofovir in Naive Patients With Chronic Hepatitis b
Status: UNKNOWN
Conditions: Chronic Hepatitis b
Interventions: DRUG: TDF tablet|DRUG: QL-007
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treating Idiopathic Inflammatory Myopathies Related Reduced Bone Mineral Density With Denosumab or Zoledronic Acid
Status: UNKNOWN
Conditions: Idiopathic Inflammatory Myopathies|Osteoporosis, Osteopenia
Interventions: DRUG: Denosumab|DRUG: Zoledronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crossover Target Engagement Study of Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease (Project #3 - Experiment 3 [UdallP3E3])
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Varenicline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability of ILB-202
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ILB-202|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Ventilator-Associated Pneumonia by Automatic Control of the Tracheal Tube Cuff Pressure
Status: COMPLETED
Conditions: Ventilator-Associated Pneumonia|Mechanical Ventilation
Interventions: DEVICE: Automatic control of tracheal tube cuff pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate an Investigational Drug in Patients With Mixed Hyperlipidemia (0653A-071)(COMPLETED)
Status: COMPLETED
Conditions: Hyperlipidemia|Hypercholesterolemia|Hypertriglyceridemia
Interventions: DRUG: ezetimibe (+) simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tech4Rest Trial With Team Truck Drivers
Status: COMPLETED
Conditions: Sleep|Sleep Disturbance|Sleep Disorder, Shift Work|Health Knowledge, Attitudes, Practice|Health Behavior|Fatigue|Vibration; Exposure
Interventions: OTHER: Enhanced Cab|BEHAVIORAL: Fit4Sleep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Fecal Incontinence Using Allogenic-Adipose-derived Mesenchymal Stem Cells: A Prospective, Dose Escalation, Randomized, Placebo-controlled, Parallel-group, Single-blind, Single-center Pilot Study
Status: COMPLETED
Conditions: Fecal Incontinence
Interventions: BIOLOGICAL: ALLO-ASC injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Tenofovir, Emtricitabine, Maraviroc, and Raltegravir in Cervical, Vaginal, and Rectal Tissues and Secretions
Status: COMPLETED
Conditions: Healthy Adult Females
Interventions: OTHER: Pharmacokinetic Sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial to Evaluate Two Schedules of MS275 in Combination With 5AC in Elderly Patients With Acute Myeloid Leukemia (AML)
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Entinostat days 3, 10|DRUG: 5AC|DRUG: Entinostat days 10,17
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stress-Reducing Interventions in HIV+ Patients: Pilot
Status: UNKNOWN
Conditions: Stress Disorders, Post-Traumatic|HIV Infections
Interventions: BEHAVIORAL: Prolonged Exposure Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Satisfaction Following Twice Daily Dosing With DFD-01 in Subjects With Moderate Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: DFD-01 (betamethasone dipropionate) Spray, 0.05%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ELIRA 2: Safety and Effectiveness of TENS Assisted Weight Loss and Appetite Suppression
Status: COMPLETED
Conditions: Weight Loss
Interventions: DEVICE: Transcutaneous Nerve Stimulator (TENS)|BEHAVIORAL: Diet & Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effectiveness of Two Psycho-physical Interventions: Mindfulness Based Relapse Prevention (MBRP) and Unguided Meditative Relaxation in Patients With Alcohol Use Disorder
Status: RECRUITING
Conditions: Alcohol Use Disorder (AUD)
Interventions: BEHAVIORAL: Mindfulness Based Relapse Prevention|BEHAVIORAL: Relaxation/ meditation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Local Injury of the Endometrium Improve Controlled Ovarian Hyperstimulation (COH) + Intrauterine Insemination (IUI) Outcome?
Status: UNKNOWN
Conditions: Infertility|Implantation Failure
Interventions: PROCEDURE: endometrial biopsy|PROCEDURE: endometrial biopsy|PROCEDURE: natural cycle + IUI + endometrial biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Mental Activity and eXercise Trial for Seniors
Status: COMPLETED
Conditions: Cognitive Impairment
Interventions: BEHAVIORAL: Group 1|BEHAVIORAL: Group 2|BEHAVIORAL: Group 3|BEHAVIORAL: Group 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study of PM01183 in Patients With Acute Leukemia or Relapsed/Refractory Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Acute Leukemia
Interventions: DRUG: PM01183 1 mg Powder for concentrate for solution for infusion and PM01183 4 mg Powder for concentrate for solution for infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: The Effect of Welchol on Glucose Metabolism in Type 2 Diabetics
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Colesevelam|OTHER: Placebo|BEHAVIORAL: Diet|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Feasibility Study of the Amaranth Medical FORTITUDE Bioresorbable Drug-Eluting Coronary Stent
Status: UNKNOWN
Conditions: Coronary Artery Disease|Myocardial Ischemia
Interventions: DEVICE: AmM FORTITUDE Bioresorbable Drug-Eluting Coronary Scaffold
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Acceptability of Ivermectin ODT in PSAC
Status: COMPLETED
Conditions: Trichuriasis|Ascariasis|Hookworm Infections
Interventions: DRUG: Ivermectin 1.5 mg ODT|DRUG: Ivermectin 3 mg Oral Tablet|DRUG: Albendazole 400 mg Oral Tablet|DRUG: Placebo IVM ODT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Does GLP-1RA Prevent Deterioration of Metabolic State in Prediabetic and Diabetic Patients Treated With Antipsychotic Medication?
Status: ACTIVE_NOT_RECRUITING
Conditions: Metabolic Disturbance|Schizophrenia|Type 2 Diabetes|Clozapine|GLP-1|Olanzapine
Interventions: DRUG: Semaglutide, 1.34 mg/mL|DRUG: Semaglutide-placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aequalis Resurfacing Head Study
Status: UNKNOWN
Conditions: Localized, Primary Osteoarthritis|Post-traumatic Arthrosis of Other Joints, Shoulder Region|Avascular Necrosis of the Head of Humerus
Interventions: DEVICE: Shoulder hemi-arthroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MTX110 by Convection-Enhanced Delivery in Treating Participants With Newly-Diagnosed Diffuse Intrinsic Pontine Glioma
Status: COMPLETED
Conditions: Diffuse Intrinsic Pontine Glioma
Interventions: DRUG: Panobinostat Nanoparticle Formulation MTX110|DRUG: Convection-Enhanced Delivery (CED)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Oral IXAZOMIB in Adult Participants With Relapsed and/or Refractory Follicular Lymphoma
Status: COMPLETED
Conditions: Follicular Lymphoma
Interventions: DRUG: IXAZOMIB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Behavioral Lifestyle Intervention for Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) in Adults
Status: ENROLLING_BY_INVITATION
Conditions: Metabolic Associated-dysfunction Steatotic Liver Disease (MASLD)|Metabolic Associated-dysfunction Steatohepatitis (MASH)
Interventions: BEHAVIORAL: Standard of care acceptance-based behavioral weight loss program|BEHAVIORAL: Occupational therapy dietary and lifestyle modifications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Local Anesthesia on Postoperative Pain Following Sacrospinous Ligament Fixation
Status: UNKNOWN
Conditions: Pelvic Organ Prolapse
Interventions: DRUG: Bupivacaine liposomal|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: National Longitudinal Cohort of Hematological Diseases
Status: RECRUITING
Conditions: Multiple Myeloma|Myeloma, Multiple|Myelomas, Multiple|Acute Myeloid Leukemia|Leukemias, Acute Myeloid|Myeloid Leukemias, Acute|Hemophilia|Hemophilia A|Hemophilia As|Hemophilia B|Hemophilia Bs|Myelodysplastic Syndrome|MDS|Lymphoma|Leukemia|Aplastic Anemia|Bleeding Disorder|Bone Marrow Transplantation|Blood Disease Infection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Benefits of 'Repeat Back' Protocols Within A Computer-Based Informed Consent Program
Status: COMPLETED
Conditions: Surgery|Cholecystectomy, Laparoscopic|Prostatectomy|Arthroplasty, Replacement, Hip|Endarterectomy, Carotid
Interventions: OTHER: Enhanced surgical iMedConsent process (with "repeat back")|OTHER: standard surgical iMedConsent process
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Combination Chemoembolization and Stereotactic Body Radiation Therapy in Unresectable Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: RADIATION: SBRT|DRUG: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Superficial Cervical Plexus Blockade for Clavicle Fracture Analgesia
Status: WITHDRAWN
Conditions: Pain, Postoperative|Satisfaction
Interventions: DRUG: Ropivacaine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Prospective Observational Study to Evaluate Long-term Changes in Cartilage Morphology in Subjects Who Previously Received TPX-100 or Placebo in Study TPX-100-1 for Patellar Osteoarthritis Involving Both Knees
Status: COMPLETED
Conditions: Mild to Moderate Knee OA
Interventions: OTHER: Previous treated with TPX-100
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Electroconvulsive Therapy for Treatment Refractory Schizophrenia - A Randomized, Double-blinded, Sham-controlled Study
Status: TERMINATED
Conditions: Treatment-refractory Schizophrenia
Interventions: PROCEDURE: ECT|PROCEDURE: SHAM ECT|DRUG: Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Patient Registry Study for Patients Treated With Voretigene Neparvovec in US
Status: ACTIVE_NOT_RECRUITING
Conditions: Confirmed Biallelic RPE65 Mutation-associated Retinal Dystrophy
Interventions: BIOLOGICAL: AAV2-hRPE65v2,voretigene neparvovec-rzyl
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lung B.A.S.E.S. 4 Life Mobile Low-dose Computed Tomography (LDCT) Screening: Ages 40-54
Status: RECRUITING
Conditions: Lung Neoplasms|Lung Cancer
Interventions: OTHER: Mobile Low-dose Computed Tomography (LDCT) Screening
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: An Open-Label, Long-Term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipation
Status: COMPLETED
Conditions: Chronic Constipation|Irritable Bowel Syndrome With Constipation
Interventions: DRUG: Linaclotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Response Study of Probiotic Bacteria BB-12 and CRL-431 in Healthy Young Adults
Status: COMPLETED
Conditions: Cardiovascular Disease|Constipation
Interventions: DIETARY_SUPPLEMENT: BB-12 and CRL 431
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: Pharmacokinetics and Dynamics of Dexmedetomidine as Adjuvant in TAP Block
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Dexmedetomidine|DRUG: bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of TC+AVASTIN Versus TC in Patients With Metastatic Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Neoplasms
Interventions: DRUG: Paclitaxel|DRUG: Bevacizumab|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Weight Loss on Hepatic and Muscle Lipid Content and on Insulin Sensitivity on Obese Adolescents With NAFLD
Status: COMPLETED
Conditions: Fatty Liver|Insulin Resistance
Interventions: OTHER: Low-fat diet|OTHER: Traditional diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Docetaxel in Treating Older Patients With Stage III or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of a Non-Incised Minimally Invasive Flap Procedure in Conjunction With Emdogain® MI Compared to Traditional SRCP
Status: RECRUITING
Conditions: Periodontitis|Attachment Loss, Periodontal
Interventions: PROCEDURE: Minimally invasive periodontal therapy with use of Emdogain|PROCEDURE: Minimally invasive periodontal therapy without the use of Emdogain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Pain Management Via Spinal Cord Stimulation and Blood Pressure Reduction
Status: RECRUITING
Conditions: Chronic Pain|Hypertension|Diuretics Drug Reactions|SCS
Interventions: DRUG: Hydrochlorothiazide 12.5mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study in PRE-manifest Huntington's Disease of Coenzyme Q10 (UbiquinonE) Leading to Preventive Trials (PREQUEL)
Status: COMPLETED
Conditions: Huntington's Disease
Interventions: DRUG: CoQ10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Metabolic Effects of Omentectomy
Status: TERMINATED
Conditions: Patients Who Consented to Undergo Laparoscopic Gastric Banding Surgery for Weight Loss and Consent to Participate in This studyBMI ≥35 kg/m2|Confirmed Type 2 Diabetes Treated With Oral Agents and/or Only Diet Therapy|Age 18-64 Years
Interventions: PROCEDURE: Omentectomy|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Safety, Tolerability and Preliminary Efficacy of BKM120, PI3K Kinase Inhibitor, With Advanced Leukemias
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: BKM120
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Nivolumab Plus Brentuximab Vedotin Versus Brentuximab Vedotin Alone in Patients With Advanced Stage Classical Hodgkin Lymphoma, Who Are Relapsed/ Refractory or Who Are Not Eligible for Autologous Stem Cell Transplant,
Status: TERMINATED
Conditions: Hodgkin's Disease
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: Brentuximab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aggressive Smoldering Curative Approach Evaluating Novel Therapies and Transplant
Status: ACTIVE_NOT_RECRUITING
Conditions: Smoldering Multiple Myeloma
Interventions: DRUG: Carfilzomib|DRUG: Lenalidomide|DRUG: Daratumumab|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Information-Motivation-Behavioral Model-based Continuity of Care on the Peri-implantitis Recovery in Diabetic Implant Overdenture Patients
Status: COMPLETED
Conditions: Bone Resorption|Diabetes
Interventions: BEHAVIORAL: IMB model-based continuity of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Information and Communication Technologies (ICTS) in Dentistry for SUS
Status: UNKNOWN
Conditions: Dental Caries in Children|Dental Diseases
Interventions: OTHER: Telemonitoring and teleorientation|OTHER: Control Group - Waiting list
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study Looking at the Effectiveness and Safety of a COVID-19 Vaccine in South African Adults
Status: COMPLETED
Conditions: SARS-CoV-2 Infection|COVID-19
Interventions: BIOLOGICAL: SARS-CoV-2 rS/Matrix-M1 Adjuvant|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cisplatin Plus Etoposide With or Without Paclitaxel in Treating Patients With Extensive-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: etoposide|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Wound Infiltration After Hallux Valgus Surgery
Status: COMPLETED
Conditions: Hallux Valgus
Interventions: DEVICE: Wound infiltration catheter|DRUG: NaCl 0.9%|DRUG: Ropivacaine 0.2%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Scapular Stabilization Exercises Versus Virtual Reality Exercises in Basketball Players With Scapular Dyskinesia
Status: NOT_YET_RECRUITING
Conditions: Scapular Dyskinesis
Interventions: OTHER: scapular stabilization exercises|OTHER: virtual reality exercises|OTHER: regular routine exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Airway Pressure During Nasal High Flow and CPAP in Neonates
Status: COMPLETED
Conditions: Respiratory Insufficiency
Interventions: DEVICE: NHF small cannula|DEVICE: NHF big cannula|DEVICE: CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Probiotic BL NCC 2705 and Gluten Sensitivity
Status: COMPLETED
Conditions: Celiac Disease|Non-celiac Gluten Sensitivity
Interventions: DIETARY_SUPPLEMENT: Intervention 1 : BL NCC 2705 + Maltodextrin|OTHER: Intervention 1 : Maltodextrin|DIETARY_SUPPLEMENT: Intervention 2 : BL NCC 2705 + Maltodextrin|OTHER: Intervention 2 : Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment Effects From Aerobic Endurance Training and Maximal Strength Training in Patients Suffering From Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Cardiovascular Disease
Interventions: OTHER: Aerobic high-intensity interval training (AIT)|OTHER: Computer game training (CG)|OTHER: Maximal strength training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Intravitreal Plasma Kallikrein Inhibitor, KVD001, in Subjects With Center-involving Diabetic Macular Edema (ciDME)
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: KVD001 Injection|OTHER: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy of WELT-IP in Insomnia (WCTP-I-B-01)
Status: COMPLETED
Conditions: Insomnia
Interventions: DEVICE: WELT-IP|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Fluoroscopic vs CT Guided Core Needle Biopsy for Spinal Infection and Tumor
Status: COMPLETED
Conditions: Spondylodiskitis|Spinal Tumor
Interventions: DIAGNOSTIC_TEST: Fluoroscopy Guided Spinal Biopsy|DIAGNOSTIC_TEST: CT guided Spinal Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Weekly Subcutaneous MLN1202 in Improving Diabetic Nephropathy in Participants With Macroalbuminuria
Status: WITHDRAWN
Conditions: Diabetic Nephropathy
Interventions: DRUG: MLN1202 Placebo|DRUG: MLN1202
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pro-arrhythmic Potential of GSK3039294 in Healthy Subjects
Status: WITHDRAWN
Conditions: Amyloidosis
Interventions: DRUG: GSK3039294|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Pharmacokinetics of Verinurad and Allopurinol in Asian and Chinese Subjects
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Verinurad|DRUG: Allopurinol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RD13-01 for Patients With r/r CD7+ T/NK Cell Hematologic Malignancies
Status: COMPLETED
Conditions: Hematologic Malignancies
Interventions: DRUG: RD13-01 cell infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Initial Hemato-immunological Profile on the Evolution of Immunological Thrombopenic Purpura.
Status: COMPLETED
Conditions: Immune Thrombocytopenic Purpura|Autoimmune Thrombocytopenia|Thrombopenia
Interventions: BIOLOGICAL: Collection of biological samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mitochondrial DNA in Vitreous Fluid and Blood in Patients With Eye Disease or Ocular Trauma.
Status: WITHDRAWN
Conditions: Eye Diseases|Ophthalmic Trauma|Mitochondrial DNA|Age Related Macular Degeneration|Glaucoma|Diabetic Retinopathy
Interventions: OTHER: Sample collection from tissue discard
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p