pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Treatment Protocol for Use of Anascorp™ in Patients With Scorpion Sting Envenomation
Status: COMPLETED
Conditions: Scorpion Sting Envenomation
Interventions: DRUG: Antivenin Centruroides (scorpion) F(ab)2 Anascorp™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Vasopressor on the Graft Blood Flow in TRAM
Status: COMPLETED
Conditions: Blood Flow|Anastomotic Failure of Flap|Flap Necrosis|Flap Ischemia
Interventions: DRUG: Norepinephrine|DRUG: Phenylephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Valsartan Plus Hydrochlorothiazide in Fixed Dose Combination in Hypertensive Patients Not Controlled by the Free Combination of an Angiotensin Receptor Blocker Plus Hydrochlorothiazide
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Valsartan plus Hydrochlorothiazide|DRUG: Candesartan plus Hydrochlorothiazide|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of 5HTP on the Injured Human Spinal Cord
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: DRUG: 5-Hydroxytryptophan 100 MG|DRUG: 5-Hydroxytryptophan|DRUG: Carbidopa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy Study of Gene Therapy for The Treatment of Acute LHON Onset Within Three Months
Status: UNKNOWN
Conditions: Acute LHON|Onset Within Three Months|Onset Between 3 to 6 Months|Onset Between 6 to 12 Months|Onset Between 12 to 24 Months|Onset Between 24 to 60 Months|Onset Over 60 Months
Interventions: DRUG: rAAV2-ND4
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lung Transplant Plasmapheresis/Belatacept/Carfilzomib for Antibody Mediated Rejection and Desensitization
Status: WITHDRAWN
Conditions: Lung Transplant Rejection|Antibody-mediated Rejection
Interventions: DRUG: Belatacept|DRUG: Carfilzomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of a Device to Deliver Intra-Operative Therapeutic Hypothermia for Hearing Preservation in Cochlear Implantation
Status: NOT_YET_RECRUITING
Conditions: Cochlear Implants|Cochlear Implantation|Hearing Loss
Interventions: DEVICE: Intra-Ear Canal Cooling Catheter|DEVICE: Intra-Ear Canal Cooling Catheter (Sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Follow-net Investigation of a Randomised Study of Cystoscopy and Urethral Dilatation Versus Cystoscopy Alone in Women With Overactive Bladder Syndrome and Impaired Voiding
Status: WITHDRAWN
Conditions: Overactive Bladder|Voiding Dysfunction|Urinary Incontinence
Interventions: PROCEDURE: Cystoscopy only|PROCEDURE: Cystoscopy and Urethral dilatation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunogenicity and Safety of GBS-NN/NN2 in Pregnant Women
Status: COMPLETED
Conditions: Group B Streptococcal Infection
Interventions: BIOLOGICAL: GBS-NN/NN2 Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transcranial Direct Current Stimulation on Cortical Plasticity in Patients With Anti-NMDA Receptor Encephalitis
Status: COMPLETED
Conditions: Anti-NMDA Receptor Encephalitis
Interventions: DEVICE: tDCS|DEVICE: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison Of The Analgesic Efficacy Of IPACK (Interspace Between The Popliteal Artery And Capsule Of The Posterior Knee) Block Alone And IPACK Block Combined With Genicular Block In Patients Planned For Total Knee Arthroplasty
Status: COMPLETED
Conditions: Pain, Joint|Knee Arthropathy|Anesthesia|Orthopedic Disorder
Interventions: PROCEDURE: IPACK + Genicular Nerve Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Medical Researchers' Self-learning With an Intelligent Language Model
Status: RECRUITING
Conditions: Medical Artificial Intelligence|Interdisciplinary Research|Self-Directed Learning
Interventions: OTHER: Intelligent Language Model|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: NIRF Trial: Near-Infrared Spectroscopy for Intraoperative Restriction of Fluids Trial
Status: COMPLETED
Conditions: Colorectal Surgery
Interventions: PROCEDURE: Restricted intraoperative fluid management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dexamethasone-bupivacaine Versus Bupivacaine for Tonsillectomy Pain.
Status: UNKNOWN
Conditions: Tonsillectomy
Interventions: DRUG: Bupivacaine 0.5%|DRUG: Bupivacaine 0.5% , Dexamethasone|DRUG: Nacl 0,9 %
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study of Human Papillomavirus (HPV) 16 Vaccine in the Prevention of HPV 16 Infection in 16- to 23-Year-Old Females (V501-005)
Status: COMPLETED
Conditions: HPV 16 Infection
Interventions: BIOLOGICAL: Comparator: HPV 16 L1 Vaccine|BIOLOGICAL: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Intrathecal Atropine vs IV Metoclopramide for Nausea & Vomiting During CS
Status: COMPLETED
Conditions: Nausea|Vomiting
Interventions: DRUG: Atropine sulfate|DRUG: Metoclopramide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Survey of Recombinant ADAMTS13 in Participants With Congenital Thrombotic Thrombocytopenic Purpura
Status: RECRUITING
Conditions: Thrombotic Thrombocytopenic Purpura (TTP)
Interventions: DRUG: Recombinant ADAMTS13
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Drug-Eluting Balloon Catheters and the Treatment of Peripheral Arterial Occlusive Disease
Status: COMPLETED
Conditions: Peripheral Arterial Disease|Stenotic Femoro-popliteal Arteries|Occluded Femoro-popliteal Arteries|Atherosclerosis
Interventions: DEVICE: Paclitaxel-coated balloon catheter angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hands4Health: A Multi-component Intervention on Hand Hygiene & Well-being in Schools in Nigeria & Palestine (H4H)
Status: COMPLETED
Conditions: Hand Hygiene|Handwashing Behaviour|Well-Being
Interventions: OTHER: Multi-component hand hygiene intervention in primary schools not connected to functional water supply system in Nigeria and Palestine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Thorax MRI for Evaluation of Lung Morphology, Ventilation and Perfusion
Status: NOT_YET_RECRUITING
Conditions: Lung Diseases|Interstitial Lung Disease
Interventions: DIAGNOSTIC_TEST: MRI of the chest
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Microglial Activation on Synaptic Density in Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: RADIATION: [11C]-UCB-J|RADIATION: [18F]-DPA-714|RADIATION: [18F]-RO-948|RADIATION: [11C]-PiB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: B7-H3 Chimeric Antigen Receptor T Cells (B7-H3CART) in Recurrent Glioblastoma Multiforme
Status: RECRUITING
Conditions: Brain and Nervous System
Interventions: DRUG: B7-H3CART
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase-II Study Of TOMUDEX Plus Radiotherapy In Subject With Inoperable or Recurrent Rectal Cancer
Status: COMPLETED
Conditions: Inoperable or Recurrent Rectal Cancer
Interventions: DRUG: Tomudex|PROCEDURE: Radiotherapy|PROCEDURE: Haematology|PROCEDURE: Biochemistry
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Defining the Normal Human Response to Probiotics
Status: COMPLETED
Conditions: Healthy Response to Probiotics
Interventions: DIETARY_SUPPLEMENT: LGG|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immunogenicity Assessment of Peg-filgrastim vs. Neulasta® as Adjunct to Chemotherapy in Patients With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Lupin's Pegfilgrastim|DRUG: Neulasta®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Breastmilk in Children Receiving a Bone Marrow Transplant
Status: COMPLETED
Conditions: Bone Marrow Transplant- Autologous or Allogeneic
Interventions: DIETARY_SUPPLEMENT: Breastmilk
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intramyocardial Multiple Precision Injection of Bone Marrow Mononuclear Cells in Myocardial Ischemia
Status: TERMINATED
Conditions: Heart Failure
Interventions: PROCEDURE: NOGA XP Cardiac Navigation System|PROCEDURE: NOGA XP Cardiac Navigation System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Accuracy of Cuffless Ambulatory Blood Pressure Monitors Compared to Cuff-based Monitors in an Ambulatory Elderly Population: A Pilot Study
Status: NOT_YET_RECRUITING
Conditions: Hypertension
Interventions: DEVICE: Aktiia SA Bracelet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Study of NXL104/Ceftazidime Versus Comparator in Adults With Complicated Urinary Tract Infections
Status: COMPLETED
Conditions: Complicated Urinary Tract Infection
Interventions: DRUG: NXL104/ceftazidime|DRUG: Imipenem/Cilastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Gene Modified Donor T Cell Infusion in Patients With Recurrent Disease After Allogeneic Transplant
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukemia|Myelodysplastic Syndromes|Lymphoma|Multiple Myeloma|Hematologic Neoplasms
Interventions: BIOLOGICAL: BPX-501|DRUG: Rimiducid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dry vs Wet Misoprostol for Cervical Dilation in First Trimester Abortion
Status: COMPLETED
Conditions: Abortion Early
Interventions: DRUG: dry misoprostol|DRUG: wet misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Photodynamic Therapy With HPPH for Treatment of Dysplasia, Carcinoma in Situ and T1 Carcinoma of the Oral Cavity and/or Oropharynx
Status: COMPLETED
Conditions: Dysplasia|Carcinoma of the Oral Cavity|Carcinoma of the Oropharynx
Interventions: DRUG: HPPH
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Sugar-sweetened Beverage Consumption Among Young Adults
Status: COMPLETED
Conditions: Intention|Health Knowledge, Attitudes, Practice
Interventions: OTHER: loss-frame|OTHER: gain-frame|OTHER: text-only|OTHER: icon|OTHER: attribution|OTHER: no attribution|OTHER: No label
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Safety and Efficacy of APR-246 in Combination With Azacitidine
Status: UNKNOWN
Conditions: Myelodysplastic Syndrome With Gene Mutation|Acute Myeloid Leukemia With Gene Mutations|Myeloproliferative Neoplasm|Chronic Myelomonocytic Leukemia
Interventions: DRUG: APR-246|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity Study of the Covid-19 (Recombinante) Vaccine With a 4 or 8 Week Interval Between the First Doses.
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: Covid-19 (recombinante) vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of CAR-T Cells Targeting GPRC5D in the Treatment of r/r Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: GPRC5D-CAR-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Comorbidities in Chronic Heart Failure Study
Status: COMPLETED
Conditions: Heart Failure|Comorbidity|Osteoporosis|Pulse Wave Analysis|Blood Pressure Monitoring, Ambulatory|Osteoporotic Fractures
Interventions: RADIATION: X-ray of the spine|PROCEDURE: Ambulatory blood pressure monitoring (ABPM)|RADIATION: Dual X-ray absorptiometry|PROCEDURE: Non-invasive procedures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Brain and Mindfulness
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Magneto-encephalography (MEG)|OTHER: Electro-encephalography (EEG)|OTHER: Functional Magnetic Resonance Imaging (fMRI)|OTHER: Anatomical Magnetic Resonance Imaging (aMRI)|OTHER: Meditation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of the Efficacy and Safety of Sirolimus Versus Everolimus Versus Mycophenolate in Kidney Transplantation
Status: COMPLETED
Conditions: Kidney Transplant Infection
Interventions: DRUG: Sirolimus|DRUG: Everolimus|DRUG: Mycophenolic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Once-weekly Versus Twice-weekly Carfilzomib in Combination With Dexamethasone in Adults With Relapsed and Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Carfilzomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Probiotics on Sperm Quality in Middle-aged Men
Status: NOT_YET_RECRUITING
Conditions: Sperm Quality
Interventions: DIETARY_SUPPLEMENT: probiotic product|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adebelimab Combined With Irinotecan Liposomal Injection, Oxaliplatin, Fluorouracil and Calcium Folinate Are Used in the First-line Treatment of Pancreatic Cancer Liver Metastasis Efficacy and Safety
Status: RECRUITING
Conditions: Pancreatic Cancer Metastatic to Liver
Interventions: DRUG: Irinotecan liposome|DRUG: Adebrelimab|DRUG: Oxaliplatin|DRUG: Fluorouracil|DRUG: Calcium folinate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyoscine Butylbromide for Prevention of Bradycardia During Cesarean Section
Status: COMPLETED
Conditions: Bradycardia|Spinal Anesthetics Causing Adverse Effects in Therapeutic Use|Cesarean Section Complications
Interventions: DRUG: Hyoscine Butylbromide 20 Mg/mL Solution for Injection Ampoule|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of RP3 Monotherapy and RP3 in Combination With Nivolumab in Patients With Solid Tumours
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumor
Interventions: BIOLOGICAL: RP3|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metabolic Pathology of Pediatric NAFLD
Status: RECRUITING
Conditions: Nonalcoholic Fatty Liver|Nonalcoholic Steatohepatitis|Obesity
Interventions: OTHER: Oral sugar tolerance test|OTHER: De novo lipogenesis test|OTHER: Gluconeogenesis test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Real-World Study of Neoadjuvant/Conversion Therapy for Colorectal Cancer With Chemotherapy And Anti-Angiogenic Targeted Agents
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer
Interventions: COMBINATION_PRODUCT: corhot1: chemotherapy combined with fruquintinib|COMBINATION_PRODUCT: corhot2: chemotherapy combined with fruquintinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Outcome of IV Acetaminophen Use in Laparoscopic Cholecystectomies in Patients at Risk of OSA
Status: WITHDRAWN
Conditions: Cholecystitis|Cholelithiasis|Obstructive Sleep Apnea
Interventions: DRUG: acetaminophen, IV preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Amlodipine/Benazepril in the Hypertensive African-American Population With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Amlodipine/benazepril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Neural Correlates of Neurofeedback Training
Status: UNKNOWN
Conditions: Nicotine Dependence|Depression|PTSD
Interventions: OTHER: Neurofeedback training|OTHER: Sham Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Growth and Tolerance of a Partially Hydrolyzed Infant Formula
Status: COMPLETED
Conditions: Growth
Interventions: OTHER: Cow's milk protein infant formula|OTHER: Partially hydrolyzed protein infant formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Anakinra in the Management of COVID-19 Infection
Status: COMPLETED
Conditions: Covid19|Pneumonia|Cytokine Release Syndrome|Corona Virus Infection|Viral Infection
Interventions: DRUG: Anakinra|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Cardiac Rehabilitation Programs on Left Ventricular Remodeling After Acute Myocardial Infarction - the REHAB Trial
Status: COMPLETED
Conditions: Acute Myocardial Infarction|Non-ST Elevation Myocardial Infarction|Systemic Inflammation|Ventricular Remodeling|Acute Coronary Syndrome
Interventions: DIAGNOSTIC_TEST: Cardiac imaging|DIAGNOSTIC_TEST: Laboratory analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intraoperative Laser Speckle Contrast Imaging of Cerebral Blood Flow
Status: COMPLETED
Conditions: Aneurysm, AVM, Dural Arteriovenous Fistula, Glioma, Meningioma, Metastasis, Bypass
Interventions: DEVICE: Laser speckle contrast imaging (LSCI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Mesenchymal Stem Cells for Pediatric Perianal Fistulizing Crohn's Disease
Status: UNKNOWN
Conditions: Perianal Fistula Due to Crohn's Disease (Disorder)
Interventions: DRUG: Mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With Depression
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: BI 1358894|DRUG: Placebo|DRUG: Quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Role of High-Throughput Whole Genome Sequencing for the Diagnosis and Care of Atypical Diabetes
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus
Interventions: DIAGNOSTIC_TEST: WGS coupled with MCM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Iron Sucrose Versus Ferrous Bis-glycinate for Treatment of Iron Deficiency Anemia
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Iron Sucrose Injection|DRUG: Ferrous Bisglycinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of BAY1862864 Injection in Subjects With Relapsed or Refractory CD22-positive Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin
Interventions: DRUG: BAY1862864
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Olanzapine and Fluoxetine for Treatment-resistant Depression
Status: TERMINATED
Conditions: Treatment Resistant Depression
Interventions: DRUG: Olanzapine|DRUG: Fluoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bendamustine and Erlotinib in Treating Patients With Stage IIIB, Stage IIIC, or Stage IV Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: bendamustine|DRUG: erlotinib|DRUG: Maintenance erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety & Bioequivalence of a Generic Butenafine Cream & Lotrimin Ultra® & Compare Both to a Vehicle Control in Treatment of Interdigital Tinea Pedis
Status: COMPLETED
Conditions: Tinea Pedis
Interventions: DRUG: Butenafine Hydrochloride Cream, 1%|DRUG: Lotrimin Ultra®|DRUG: Butenafine Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assess the Efficacy of AZD8931 in Combination With Paclitaxel Versus Paclitaxel Alone in Patients With Gastric Cancer
Status: TERMINATED
Conditions: Metastatic, Gastric or Gastro-oesophageal Junction, Cancer
Interventions: DRUG: AZD8931|DRUG: Placebo|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Ikervis Under Controlled Environmental Conditions Environment
Status: COMPLETED
Conditions: Dry Eye|Dry Eye Syndromes|Severe Keratitis
Interventions: DRUG: IKERVIS®1mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Two Levels of Arterial Pressure on Survival in Patients With Septic Shock
Status: COMPLETED
Conditions: Septic Shock|Arterial Pressure|Hemodynamics|Mortality|Clinical Trial
Interventions: DRUG: maintain mean arterial pressure between 80-85 mm Hg|OTHER: maintain mean arterial pressure between 65-70 mm Hg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Parotid Sparing Whole Brain Radiation
Status: COMPLETED
Conditions: Xerostomia
Interventions: RADIATION: Parotid sparing WBRT|RADIATION: Standard WBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Radiation Therapy and High-Dose Corticosteroids in Treating Older Patients With Primary CNS Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: dexamethasone|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Milrinone Versus Sildenafil in the Treatment of Neonates With Persistent Pulmonary Hypertension
Status: COMPLETED
Conditions: Persistent Pulmonary Hypertension
Interventions: DRUG: Milrinone|DRUG: Sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Visual Outcomes After Implantation of the Synthesis Plus and Synthesis Plus Toric
Status: RECRUITING
Conditions: Cataract|Surgery|IOL
Interventions: DEVICE: Implantation of Synthesis Plus IOL (control device)|DEVICE: Implantation of Synthesis Plus Toric IOL (investigational device)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Integrated Echocardiography and Chest Ultrasound Assessment of Lung Recruitment in Preterm Infants
Status: RECRUITING
Conditions: Ventilator Lung|Echocardiography|Chest Ultrasound|High Frequency Ventilation|Lung Recruitment
Interventions: OTHER: Lung recruitment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Differing Dosing Regimens of ISV-303 (Bromfenac in DuraSite) to Xibrom and Vehicle in Post Cataract Surgery Volunteers
Status: COMPLETED
Conditions: Ocular Inflammation
Interventions: DRUG: ISV-303|DRUG: ISV-303|DRUG: DuraSite Vehicle|DRUG: Xibrom™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Sweet Esophagectomy for Patients With Siewert Type II Adenocarcinoma of the Esophagogastric Junction
Status: UNKNOWN
Conditions: Adenocarcinoma
Interventions: PROCEDURE: Minimally invasive group|PROCEDURE: Open group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of SPD503 in Combination With Psychostimulants
Status: COMPLETED
Conditions: ADHD
Interventions: DRUG: SPD503-AM|DRUG: SPD503-PM|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of the Effects of 6R-BH4 in Subjects With Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: Sapropterin Dihydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving ObsQoR-11 With Continuous Wound Infusion Versus Intrathecal Morphine After Elective Cesarean Delivery
Status: WITHDRAWN
Conditions: Quality of Recovery|Anesthesia|Postoperative Pain|Cesarean Section
Interventions: DRUG: Intrathecal Morphine|DRUG: Ropivacaine 0.2%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of GNC-035 in Relapsed or Refractory Chronic Lymphocytic Leukemia and Other Hematological Malignancies
Status: RECRUITING
Conditions: Relapsed/Refractory Chronic Lymphocytic Leukemia
Interventions: DRUG: GNC-035
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Head Lice Infestation Using Novel Ultrasonic Comb
Status: COMPLETED
Conditions: Pediculus Capitis
Interventions: DEVICE: The Lucy ultrasonic comb models A and B combined with the LucyGel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study to Evaluate Long-Term Outcome in Hip Hemiarthroplasty
Status: RECRUITING
Conditions: Hip Fractures|Hip Hemiarthroplasty|Osteoarthritis, Hip|Avascular Necrosis of Hip|Femoral Neck Fractures
Interventions: DEVICE: Bipolar i and cemented stem (Océane+ or Meije)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lapatinib and Temozolomide for the Treatment of Progressive Brain Disease in HER-2 Positive Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer|Brain Metastases|HER2 Positive
Interventions: DRUG: lapatinib and temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contingency Outcomes in Prolonged Exposure
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder|Substance Use Disorder
Interventions: BEHAVIORAL: Prolonged Exposure Therapy|BEHAVIORAL: Voucher-Based Reinforcement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise Frequency During Endurance Training: Cardiorespiratory, Hematological, and Muscle Oxidative Adaptations
Status: COMPLETED
Conditions: Exercise Training
Interventions: OTHER: High Frequency Exercise Training|OTHER: Low Frequency Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Role of PET/MRI in Predicting the Outcome of Definitive Chemoradiotherapy for Esophageal Cancer Patients
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DIAGNOSTIC_TEST: PET/MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Assess the Safety and Tolerability After Multiple Oral Doses of AZD1656 in Patients With Type 2 Diabetes Mellitus Treated With Metformin
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: AZD1656|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dural Puncture Epidural Versus Combined Spinal Epidural With Epidural Volume Extension in Labor Analgesia
Status: COMPLETED
Conditions: Labor Pain
Interventions: DRUG: Epidural|DRUG: Intrathecal+Epidural
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OPTION 2: A Trial to Assess the Safety and Efficacy of MS1819 in Enteric Capsules in Patients With Cystic Fibrosis
Status: COMPLETED
Conditions: Exocrine Pancreatic Insufficiency (EPI)|Cystic Fibrosis (CF)
Interventions: DRUG: MS1819|DRUG: Porcine PERT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plaque Inflammation and Dysfunctional HDL in AIM-HIGH
Status: COMPLETED
Conditions: Cardiovascular Diseases|Heart Diseases|Coronary Disease|Atherosclerosis|Myocardial Infarction
Interventions: DRUG: Simvastatin and Extended-Release niacin|DRUG: Simvastatin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Two-arm (Phase 2) Exploratory Study of Nivolumab Monotherapy or in Combination With Nab-paclitaxel and Carboplatin in Early Stage NSCLC in China
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: Nivolumab|DRUG: carboplatin|DRUG: nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Pharmacokinetic Characteristics and Safety of IN-C004 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: IN-C004 with water|DRUG: IN-C004 without water|DRUG: K-CAB tab. with water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of the Central Nervous System
Status: COMPLETED
Conditions: Medulloblastoma|Pineoblastoma|Supratentorial Embryonal Tumor, Not Otherwise Specified
Interventions: RADIATION: 3-Dimensional Conformal Radiation Therapy|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Cyclophosphamide|DRUG: Etoposide Phosphate|DRUG: Isotretinoin|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Peripheral Blood Stem Cell Transplantation|DRUG: Thiotepa|DRUG: Vincristine Sulfate|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postprandial Effects of Milk and Milk Constituents
Status: COMPLETED
Conditions: Hyperlipidemia|Inflammation
Interventions: DIETARY_SUPPLEMENT: Milk|DIETARY_SUPPLEMENT: Protein|DIETARY_SUPPLEMENT: Calcium|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Adding Motivational Interviewing to Antidepressant Treatment for Hispanic Adults With Depression
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Standard antidepressant therapy (SADT)|BEHAVIORAL: Motivational antidepressant therapy (MADT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV)
Status: COMPLETED
Conditions: Congenital Cytomegalovirus Infection|Maternal Cytomegalovirus Infection
Interventions: DRUG: CMV hyperimmune globulin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Compare the Pharmacokinetics and Safety of CT-P47 and RoActemra in Healthy Subjects
Status: UNKNOWN
Conditions: Healthy Subjects
Interventions: BIOLOGICAL: CT-P47|BIOLOGICAL: EU-approved RoActemra,
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Atrasentan in Patients With IgA Nephropathy
Status: ACTIVE_NOT_RECRUITING
Conditions: IgA Nephropathy|Immunoglobulin A Nephropathy
Interventions: DRUG: Atrasentan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Efficacy of ASC42 Combined With ETV and PEG-IFN α-2a in Subjects With HBV
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: ASC42 10mg|DRUG: ASC42 15mg|DRUG: ih PEG-IFN α-2a|DRUG: Entecavir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Susceptibility to Infections, Tumor Risk and Liver Disease in Patients With Ataxia Telangiectasia
Status: UNKNOWN
Conditions: Ataxia Telangiectasia
Interventions: DIAGNOSTIC_TEST: bioelectrical impedance analysis|DIAGNOSTIC_TEST: blood draw|DIAGNOSTIC_TEST: transient elastography (FibroScan)|DIAGNOSTIC_TEST: ataxia score|DIAGNOSTIC_TEST: Five-Times-Sit-to-Stand Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Clinical Trial of COVAC-2 in Healthy Adults
Status: COMPLETED
Conditions: Severe Acute Respiratory Syndrome Coronavirus 2
Interventions: BIOLOGICAL: COVAC-2|BIOLOGICAL: Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy and Dexrazoxane Followed by Surgery and Radiation Therapy in Treating Patients With Advanced Soft Tissue Sarcoma or Recurrent Bone Sarcoma
Status: TERMINATED
Conditions: Sarcoma
Interventions: BIOLOGICAL: filgrastim|DRUG: dexrazoxane hydrochloride|DRUG: doxorubicin hydrochloride|DRUG: ifosfamide|DRUG: irinotecan hydrochloride|GENETIC: protein expression analysis|OTHER: immunoenzyme technique|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3002813 in Participants With Memory Damage Due to Alzheimer's Disease (AD) or AD
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: BIOLOGICAL: LY3002813|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sumor as Adjuvant Therapy in Treatment-resistant Major Depression
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DIETARY_SUPPLEMENT: SUMOR|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study of Preoperative Tumor-bed Boost Followed by Oncoplastic Surgery and Adjuvant Whole Breast Radiotherapy for Early Stage Breast Cancer (BIRKIN)
Status: RECRUITING
Conditions: Breast Neoplasms
Interventions: RADIATION: Preoperative MRI-guided tumor-bed boost and postopreative ultra-hypofractionated radiotherapy (26 Gy/5.2Gy/5)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Child and Adolescent Anxiety Disorders (CAMS)
Status: COMPLETED
Conditions: Anxiety Disorders|Social Phobia|Generalized Anxiety Disorder
Interventions: DRUG: Sertraline (SRT)|BEHAVIORAL: Cognitive Behavioral Therapy (CBT)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Association of Helicobacter Pylori Infection and Migraine
Status: RECRUITING
Conditions: Migraine in Children
Interventions: DIAGNOSTIC_TEST: Helicobacter pylori antigen in stool
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Dose-dense Biweekly Docetaxel, Oxaliplatin and 5-fluorouracil as First-line Treatment in Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Docetaxel, Oxaliplatin and Fluorouracil
Interventions: DRUG: Docetaxel, Oxaliplatin and 5-Fu
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: tDCS in Patients With Disorder of Consciousness Due to Severe Acquired Brain Injury
Status: TERMINATED
Conditions: Consciousness Disorders|Brain Injuries|Vegetative State|Minimally Conscious State|Cognitive Impairment
Interventions: DEVICE: Anodal tDCS|OTHER: Usual care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Topical Use of 20% Beta Caryophyllene Alone And In Combination With 0.025% Capsaicin for Pain Caused by Osteoarthritis Of The Knee
Status: COMPLETED
Conditions: Pain
Interventions: OTHER: BetaC + Capsaicin Topical Cream|OTHER: BetaC Topical Cream|OTHER: Placebo Topical Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Motion Sensor and Feedback System Efficacy to Refine Movements After Injury
Status: ENROLLING_BY_INVITATION
Conditions: Spinal Cord Injuries|Stroke|Acquired Brain Injury|Movement Disorders
Interventions: BEHAVIORAL: Kinesthetic Awareness Training|BEHAVIORAL: Provision of KAT-assisted physical or occupational therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ciprofol EC50 for Inducing Loss of Consciousness in Elderly Patients
Status: RECRUITING
Conditions: Elderly Patients
Interventions: DRUG: Ciprofol dose 0.4mg/Kg|DRUG: Ciprofol dose 0.3mg/Kg|DRUG: Ciprofol dose 0.2mg/Kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effects of Nutrition on the Maturation of Brain Networks Associated With Memory in Infants
Status: UNKNOWN
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Postnatal Dietary Supplement|DIETARY_SUPPLEMENT: Control Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sex/Gender Differences in Risk and Resilience to PTSD; Implication of Oxytocin
Status: COMPLETED
Conditions: PTSD
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Axitinib (AG-013736) With Or Without Dose Titration (Increase) In Patients With Kidney Cancer
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: axitinib|DRUG: axitinib|DRUG: axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel With or Without Imatinib Mesylate in Treating Patients With Androgen-Independent Prostate Cancer and Bone Metastases
Status: COMPLETED
Conditions: Metastatic Cancer|Prostate Cancer
Interventions: DRUG: Docetaxel|DRUG: Imatinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Optimization of MDMA-Assisted Therapy for PTSD
Status: NOT_YET_RECRUITING
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: Midomafetamine|BEHAVIORAL: Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Baked Milk in Oral Immunotherapy for Severe IgE-mediated Cow's Milk Protein Allergic Patients
Status: UNKNOWN
Conditions: Cow's Milk Allergy
Interventions: OTHER: Baked milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Oral Solution Bioavailability Study of Apixaban When Administered Through a Nasogastric Tube in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Apixaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pain Response to Cannabidiol in Opioid-induced Hyperalgesia, Acute Nociceptive Pain and Allodynia By Using a Model Mimicking Acute Pain in Healthy Adults
Status: COMPLETED
Conditions: Acute Nociceptive Pain|Hyperalgesia|Allodynia|Opioid-induced Hyperalgesia
Interventions: DRUG: CBD|DRUG: Placebo|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hypnotherapy vs. Probiotics in Children With IBS and Functional Abdominal Pain
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome|Functional Abdominal Pain Syndrome
Interventions: BEHAVIORAL: Gut-Directed Hypnotherapy|DIETARY_SUPPLEMENT: Nutritional Supplement|BEHAVIORAL: Self-Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Binimetinib in Patients With BRAF Fusion-positive Low-grade Glioma or Pancreatic Cancer (Perfume)
Status: RECRUITING
Conditions: Low-grade Glioma|Pancreatic Cancer
Interventions: DRUG: Binimetinib 15 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modelling the Interaction Between Synthetic Model Immunogens and the Induced B and T Cell Repertoires.
Status: WITHDRAWN
Conditions: Virus Diseases
Interventions: OTHER: ConM SOSIP 50 ug and ConS UFO 50 ug|OTHER: Mos3.1 100 ug|OTHER: Mos3.2 100 ug|OTHER: Mos3.3 100 ug|OTHER: Mos3.1 33 ug, Mos3.2 33 ug and Mos3.3 33 ug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Laparoscopic Bariatric Surgery: Two Regimens of Venous Thromboprophylaxis: Prospective Randomized Study
Status: UNKNOWN
Conditions: Morbid Obesity|Pulmonary Embolism
Interventions: DRUG: Enoxaparin 40 mg 2 hours before arm|DRUG: Enoxaparin 40 mg 12 hours before arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION