pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pharmacodynamic Biomarkers to Support Biosimilar Development: Interleukin-5 Antagonists
Status: COMPLETED
Conditions: Healthy Subjects|Pharmacokinetics|Pharmacodynamics
Interventions: BIOLOGICAL: Mepolizumab|BIOLOGICAL: Mepolizumab|BIOLOGICAL: Mepolizumab|BIOLOGICAL: Mepolizumab|BIOLOGICAL: Reslizumab|BIOLOGICAL: Reslizumab|BIOLOGICAL: Reslizumab|BIOLOGICAL: Reslizumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Reduction or Discontinuation of TNF-α Inhibitor in Non-infectious Uveitis Patients
Status: UNKNOWN
Conditions: Uveitis|Adalimumab
Interventions: BIOLOGICAL: reduction or discontinuation of Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Experiment on the Use of Innovative Computer Vision Technologies for Analysis of Medical Images in the Moscow Healthcare System
Status: RECRUITING
Conditions: AI (Artificial Intelligence)|Mammary Cancer|Lung Cancer|X-Rays; Lesion|COVID-19|Chest--Diseases|Abdomen Disease|Brain Disease|Fractures, Bone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Nutritional Supplementation on Physical-activity Mediated Changes in Physical Functioning Older Adults at Risk for Mobility Disability (The VIVE2 Study)
Status: COMPLETED
Conditions: Sarcopenia
Interventions: OTHER: Exercise Intervention|DIETARY_SUPPLEMENT: Supplement Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Androgel in the Treatment of Hypogonadal and Low Testosterone Men With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes|Hypogonadism
Interventions: DRUG: Androgel (testosterone gel)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Zero Acute Kidney Injury Strategy for Percutaneous Coronary Intervention in Patients With ChronicKidney Disease
Status: WITHDRAWN
Conditions: Acute Kidney Injury|Coronary Artery Disease|Percutaneous Coronary Intervention
Interventions: PROCEDURE: Standard of care Ultra Low Contrast PCI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MOnaliZumab in Combination With durvAlumab (MEDI4736) Plus Platinum-based chemotheRapy for First-line Treatment of Extensive Stage Small Cell Lung Cancer
Status: RECRUITING
Conditions: Small Cell Lung Cancer|SCLC|Extensive Stage Small Cell Lung Cancer
Interventions: DRUG: Durvalumab|DRUG: Monalizumab|DRUG: Carboplatin or Cisplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel Plus Cetuximab After First-line Checkpoint Inhibitor Failure
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Paclitaxel|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Globus Sensations With Psychotherapy
Status: COMPLETED
Conditions: Somatoform Disorders|Globus Hystericus
Interventions: BEHAVIORAL: Exposure-based psychotherapy for somatic symptoms|BEHAVIORAL: Relaxation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of SAMITAL® in the Relief of Chemo-radiation (CT-RT) Induced Oral Mucositis in Head and Neck Cancer Patients
Status: COMPLETED
Conditions: Head-and-neck Squamous Cell Carcinoma|Oral Mucositis
Interventions: DRUG: SAMITAL®|DRUG: Placebo sachets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Proof of Concept Study of Inhaled Nitric Oxide for Adults With Pulmonary Non-Tuberculous Mycobacterial Infection
Status: COMPLETED
Conditions: Nontuberculous Mycobacterium Infection
Interventions: DRUG: gNO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The REALITY Study - Head-to-Head Comparison Between Cypher and Taxus
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Cypher Sirolimus-Eluting Stent|DEVICE: Taxus Paclitaxel-Eluting Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Prograf in the Prevention of Erectile Dysfunction After Radical Prostatectomy
Status: COMPLETED
Conditions: Erectile Dysfunction|Prostate Cancer
Interventions: DRUG: Tacrolimus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Food or Supplemental Lutein Absorption
Status: WITHDRAWN
Conditions: Macula Lutea Opacity
Interventions: DIETARY_SUPPLEMENT: Lutein supplement|OTHER: Food, blended|OTHER: Food, unprocessed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dermoscopy Augmented Histology Trial, a Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Melanoma|Pigmented Lesions
Interventions: OTHER: DermLoop Learn
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Different Virtual Reality-Based Exercise Trainings on Pulmonary Function, Respiratory and Peripheral Muscle Strength, Functional Capacity and Balance in Children With Bronchiectasis
Status: COMPLETED
Conditions: Bronchiectasis
Interventions: OTHER: Conventional Chest Physiotherapy|OTHER: Nintendo Wii Fit Based Exercise Training|OTHER: BreathingLabs Breathing Games Based Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Chicken Protein Hydrolysate (CPH) Supplementation in People With High Waist Circumference
Status: COMPLETED
Conditions: Abdominal Obesity
Interventions: DIETARY_SUPPLEMENT: Chicken protein hydrolysate supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Therapy Against HCV Based on Direct-acting Antivirals in Real-life Conditions
Status: COMPLETED
Conditions: Chronic Hepatitis C Infection
Interventions: DRUG: Telaprevir|DRUG: Boceprevir|DRUG: Sofosbuvir|DRUG: Simeprevir|DRUG: Daclatasvir|DRUG: Ledipasvir|DRUG: ritonavir-boosted Paritaprevir/ Ombitasvir|DRUG: Dasabuvir|DRUG: Velpatasvir|DRUG: Elbasvir|DRUG: Grazoprevir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparing Urinary Tract Infections in Children With Spina Bifida Using Two Types of Catheters for Catheterization
Status: COMPLETED
Conditions: Neurogenic Bladder|Spina Bifida
Interventions: DEVICE: Intermittent catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Drug-drug Interaction Study(CKD-501, Amlodipine)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: CKD-501|DRUG: amlodiopine|DRUG: CKD-501 amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Stimulator of Interferon Genes (STING) Agonist E7766 in Non-muscle Invasive Bladder Cancer (NMIBC) Including Participants Unresponsive to Bacillus Calmette-Guerin (BCG) Therapy, INPUT-102
Status: WITHDRAWN
Conditions: Urinary Bladder Neoplasms
Interventions: DRUG: E7766
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Aliskiren Compared to Ramipril in the Treatment of Moderate Systolic Hypertensive Patients
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Aliskiren|DRUG: Ramipril|DRUG: Matching placebo to Aliskiren|DRUG: Matching placebo to Ramipril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium
Status: UNKNOWN
Conditions: Prostate Cancer|Carcinoma of the Rectum|Colon Cancer|Renal Carcinoma
Interventions: DRUG: Minocycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Alflutinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer Patients With T790M
Status: UNKNOWN
Conditions: Advanced NSCLC Patients With T790M
Interventions: DRUG: Alflutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ixazomib (NINLARO®) in Combination With Lenalidomide and Dexamethasone (IRD) for the Treatment of Participants With Multiple Myeloma (MM)
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Ixazomib|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Vitagliptin and Vitamin D in the Treatment of Non Alcoholic Fatty Liver Disease (NAFLD)
Status: UNKNOWN
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: DRUG: Galvus (vitagliptin)|DRUG: Galvus + vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of a Home-based Physical Activity Intervention for Family Caregivers of People With Advanced Cancer
Status: COMPLETED
Conditions: Self Care|Family Caregivers
Interventions: BEHAVIORAL: Physical activity intervention|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Mother Position in Skin-to-skin Contact Newborn on Oxygen Saturation Levels.
Status: COMPLETED
Conditions: Neonatal Disorder
Interventions: OTHER: Head-of-bed elevated 15°|OTHER: Head-of-bed elevated 45°
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Inflammasome Inhibitor on hsCRP in Patients After PCI
Status: COMPLETED
Conditions: NLRP3|hsCRP|Percutaneous Coronary Intervention
Interventions: DRUG: Colchicine|DRUG: Tranilast|DRUG: Oridonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of HCD122 in Adults With Non-Hodgkin's or Hodgkin's Lymphoma Who Have Progressed After at Least Two Prior Therapies
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma|Hodgkin's Lymphoma
Interventions: DRUG: HCD122
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interprofessional Advanced Cardiac Life Support Training on Collaborative Skills, Self-Efficacy And Emotion Regulation
Status: COMPLETED
Conditions: Self Efficacy|Collaborative Skills|Emotion Regulation
Interventions: BEHAVIORAL: IP-ACLS|BEHAVIORAL: Waitlist
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Nimotuzumab and Irinotecan as Second Line With Recurrent or Metastatic Gastric Adenocarcinoma
Status: UNKNOWN
Conditions: Stomach Neoplasms
Interventions: DRUG: Irinotecan|DRUG: nimotuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nexus of Risk: Sexual Assault, Alcohol Use, and Risky Sex Among College Women
Status: COMPLETED
Conditions: Sexual Assault|Substance Use|Risky Health Behavior|Ema
Interventions: BEHAVIORAL: Ecological Momentary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Safety Study Of A Single Vaginal Administration Of P2G12 Antibody In Healthy Female Subjects
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: P2G12
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Single Center Study Using Omalizumab in Subjects With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: BIOLOGICAL: omalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant PRRT With 177Lu-DOTATATE Followed by Surgery for Resectable PanNET
Status: COMPLETED
Conditions: Neuroendocrine Tumors
Interventions: DRUG: 177Lu-Dotatate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibudilast in the Treatment of Medication Overuse Headache
Status: UNKNOWN
Conditions: Medication Overuse Headache
Interventions: DRUG: Ibudilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Methylphenidate in Myotonic Dystrophy Type 1
Status: COMPLETED
Conditions: Dystrophia Myotonica 1
Interventions: DRUG: Methylphenidate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pericardial Effusion From Acute Myocardial Infarction: Contributing Factors and Prognosis at One Year (EPERICARDIM)
Status: UNKNOWN
Conditions: Acute Myocardial Infarction|Pericardial Effusion
Interventions: PROCEDURE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Role of Hemostatic Powder (Endo-clotTM) in Prevention of Bleeding Within High Risk Patients After ESD
Status: COMPLETED
Conditions: Iatrogenic Ulcer After ESD
Interventions: DRUG: Endo-Clot(TM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: RECOVER-HF Pilot Study of SDS in Heart Failure
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: DEVICE: Synchronized Diaphragmatic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study: A Randomized Trial Of Anesthetic Agents For Intravitreal Injection
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DRUG: Proparacaine Ophthalmic|DRUG: Tetracaine Ophthalmic|DRUG: Lidocaine 4%|DRUG: Lidocaine 2% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Inactivity Impacts on Blood Vessel Health and Glucose Levels in an Aging Population
Status: COMPLETED
Conditions: Aging|Cardiovascular Diseases|Glucose Intolerance
Interventions: DEVICE: Continuous Glucose Monitoring System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate the Immunogenicity and Safety of an Investigational Influenza Vaccine for the Elderly
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: GSK investigational FluNG vaccine GSK2186877A, aged lot|BIOLOGICAL: GSK investigational FluNG vaccine GSK2186877A, fresh lot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Seated Evaluation of Anorectal funcTion by High Resolution Anorectal Manometry
Status: COMPLETED
Conditions: Anismus|Incontinence
Interventions: OTHER: HRARM|OTHER: MRI Defecography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Does Pre-operative Carbohydrate Loading Reduce Insulin Resistance and Improve Outcomes in Elective Surgical Patients?
Status: COMPLETED
Conditions: Coronary Artery Bypass Graft Surgery|Spine Surgery
Interventions: DIETARY_SUPPLEMENT: PreOp carbohydrate drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Clinical Trial of OPS-2071 in the Treatment of Irritable Bowel Syndrome of Diarrhea Type
Status: RECRUITING
Conditions: Irritable Bowel Syndrome of Diarrhea Type (IBS-D)
Interventions: DRUG: OPS-2071|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-dose Glucagon for Prevention of Exercise-Induced Hypoglycemia in People With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes|Hypoglycemia
Interventions: DRUG: GlucaGen|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Dose of TT-00920 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: TT-00920|DRUG: TT-00920 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Global Profiling of Gene and Protein Expression Associated With Coronary Heart Disease Reversal
Status: COMPLETED
Conditions: Heart Diseases|Cardiovascular Diseases
Interventions: BEHAVIORAL: Dr. Dean Ornish Program for Reversing Heart Disease
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Red Blood Cell Exchange Transfusion as a Novel Treatment for GLUT1 Deficiency Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Glucose Transporter Type 1 Deficiency Syndrome|GLUT1DS1
Interventions: OTHER: Red Blood Cell Transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Reader Study to Assess Accuracy and Reliability of Flortaucipir F 18 Positron Emission Tomography (PET) Scan Interpretation
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: flortaucipir F 18
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Study of Intraoperative MRI-guided vs. Conventional Glioma Surgery
Status: COMPLETED
Conditions: Glioma
Interventions: PROCEDURE: intraoperative MRI-guided tumor resection|PROCEDURE: standard microsurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Middle Ear Disease Before Age 3, Treatment With Ear Tubes, and Literacy and Attentional Abilities at Ages 9 to 11
Status: COMPLETED
Conditions: Otitis Media|Middle Ear Effusion
Interventions: PROCEDURE: Insertion of tympanostomy tubes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Nicotinic Enhancement of Cognitive Remediation Training in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: BEHAVIORAL: Cognitive remediation training|DRUG: Nicotine polacrilex lozenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety of Escalating Doses of DLYE5953A in Patients With Refractory Solid Tumors
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: DLYE5953A|DRUG: DLYE5953A
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of AdCLD-CoV19-1: A COVID-19 Preventive Vaccine in Healthy Volunteers
Status: COMPLETED
Conditions: Covid19
Interventions: BIOLOGICAL: AdCLD-CoV19-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Yoga for Treating Shortness of Breath in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|Lung Diseases, Obstructive|Pulmonary Emphysema|Chronic Bronchitis
Interventions: BEHAVIORAL: yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Seltorexant in Participants With Probable Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Seltorexant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Two Regimens of IVIG in the Treatment of Newly Diagnosed ITP in Children
Status: RECRUITING
Conditions: Newly Diagnosed Immune Thrombocytopenia in Children, First Line Treatment
Interventions: DRUG: intravenous immunoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of V116 in Vaccine-naïve Japanese Older Adults (V116-009, STRIDE-9)
Status: COMPLETED
Conditions: Pneumococcal Disease
Interventions: BIOLOGICAL: V116|BIOLOGICAL: PPSV23
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of High Flex and Standard Rotating Platform Total Knee Arthroplasty (TKA)
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Rotating Platform High-Flex Cruciate Substituting TKA|DEVICE: Rotating Platform Cruciate Substituting TKA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Continuous Glucose Monitoring for Emergency Laparotomy
Status: NOT_YET_RECRUITING
Conditions: Peritonitis|Surgical Site Infection|Infections|Hyperglycemia|Hypoglycemia
Interventions: DEVICE: CGM (Dexcom G6)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ALK37-007: Evaluation of Safety and Efficacy of ALKS 37 (RDC-1036) in Adults With Opioid-induced Constipation (OIC)
Status: COMPLETED
Conditions: OIC
Interventions: DRUG: ALKS 37|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eicosapentaenoic Acid and Protein Modulation to Induce Anabolism in Chronic Obstructive Pulmonary Disease (COPD): Aim 2
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease|Muscle Wasting
Interventions: DIETARY_SUPPLEMENT: Olive oil|DIETARY_SUPPLEMENT: Fish oil|DIETARY_SUPPLEMENT: Fish oil and placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Treat & Extend Treatment With 0.5mg Ranibizumab vs Monthly Treatment With 0.5mg Ranibizumab
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DRUG: 0.5 mg ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin in Patients With Squamous Cell Carcinoma of the Lung
Status: COMPLETED
Conditions: Metastatic or Recurrent Squamous Cell Carcinoma of the Lung
Interventions: BIOLOGICAL: REOLYSIN|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prioritising Patient Medication Review: Hospitals Reaching Out
Status: NOT_YET_RECRUITING
Conditions: Medication Review|Polypharmacy|General Practitioners|Interdisciplinary Communication|Clinical Pharmacy
Interventions: OTHER: Clinical pharmacist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: To Determine if There Are Pharmacokinetic Interactions at Plasma or Intracellular Level Between Nucleosides and Tenofovir
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Patients in treatment with 3TC + TDF + LPV/rtv, stop tenofovir during 4 weeks|DRUG: Patients in treatment with ABV + TDF + LPV/rtv, stop tenofovir during 4 weeks|DRUG: Patients in treatment with 3TC + ABV + TDF+ LPV/rtv, stop TDF during 4 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study of Infliximab (CMAB008 and Remicade) in Healthy Subjects to Compare the PK and Safety
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Light Therapy for Bipolar Disorder. Efficacy of Light Therapy for Bipolar Depression: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Bipolar Disorder|Major Depressive Episode
Interventions: DEVICE: 7000lux broad-spectrum light|DEVICE: 50lux dim red light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: INulin-type Fructans-induced Gut Microbiota Modulation Impact on GUT-SKIN Axis Parameters in Psoriasis
Status: ENROLLING_BY_INVITATION
Conditions: Psoriasis
Interventions: DIETARY_SUPPLEMENT: Chicory-derived inulin-type β-fructans|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pilot Study to Evaluate the Safety and the Efficacy of the Matrix and Cells Obtained by the AmeaCell® Device and Intended for the Filling of Wrinkles on the Face.
Status: COMPLETED
Conditions: Skin Aging
Interventions: DEVICE: AmeaCell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Two Coronally Positioned Flap With Connective Tissue
Status: UNKNOWN
Conditions: Gingival Recession|Periodontal Atrophy
Interventions: PROCEDURE: coronally partial thickness flap plus connective tissue|PROCEDURE: coronally mucosal thickness flap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture and Gonadotropin-releasing Hormone Pulse Generator and Stress Axis in Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DEVICE: Low-frequency electro-acupuncture (EA)|OTHER: Meeting a therapist - attention control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: [18F]Fluoropropyl-Trimethoprim ([18F]F-TMP) PET/CT Imaging to Evaluate Biodistribution and Kinetics in Human Subjects
Status: RECRUITING
Conditions: Bacterial Infections
Interventions: DRUG: [18F]fluoropropyl-trimethoprim
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Islet Autotransplantation Compared to Oral Antidiabetic Drug.
Status: UNKNOWN
Conditions: Partial Pancreatectomy Due to Benign Pancreatic Neoplasm
Interventions: PROCEDURE: Autologous islet transplantation|DRUG: Oral anti-diabetic drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Pemetrexed and Bevacizumab for Recurrent Ovarian Primary Peritoneal Carcinoma
Status: COMPLETED
Conditions: Ovarian Carcinoma|Primary Peritoneal Carcinoma
Interventions: DRUG: Pemetrexed|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Dyadic Multisensory and Cognitive Stimulation Program for People With Dementia and Their Caregivers
Status: COMPLETED
Conditions: Dementia|Carer Stress Syndrome
Interventions: BEHAVIORAL: Dyadic MCS program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Safety Study of Human Embryonic Stem Cell Derived Mesenchymal Cells in the Treatment of Moderate and Severe Intrauterine Adhesions
Status: UNKNOWN
Conditions: Intrauterine Adhesion
Interventions: BIOLOGICAL: Inject a solution of stem cell preparation|BIOLOGICAL: Inject stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melatonin and Its Effect on the Perioperative Opioid Needs in Pediatric Patients Undergoing Laparoscopic Surgery.
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: DRUG: Melatonin 3 MG|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation in Corneal Sensation and Contact Lens Wear
Status: COMPLETED
Conditions: Cornea|Sense Loss; Cornea
Interventions: DEVICE: Tactile Esthesiometer Prototype|DEVICE: Liquid Jet Esthesiometer Prototype|DEVICE: Cochet Bonnet esthesiometer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Digital Cognitive Behavioral Therapy for Insomnia for Chronic Insomnia in Breast Cancer Survivors
Status: NOT_YET_RECRUITING
Conditions: Chronic Insomnia
Interventions: BEHAVIORAL: Digital Cognitive Behavioral Therapy for Insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maternal Emotions and Diet in Pregnancy
Status: COMPLETED
Conditions: Pregnancy Related|Stress, Psychological|Glucose Intolerance During Pregnancy
Interventions: BEHAVIORAL: Trier Social Stress Test|BEHAVIORAL: Placebo Non-stress task
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Surveillance Modified by Artificial Intelligence in Endoscopy (SMARTIE)
Status: COMPLETED
Conditions: Surveillance Endoscopy for Colorectal Cancer|Artificial Intelligence|Polyps of Colon|CADe
Interventions: DEVICE: ENDOMIND
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Liposomal Bupivacaine Versus Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy
Status: RECRUITING
Conditions: Pain, Postoperative|Pharmacokinetics
Interventions: DRUG: Exparel|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Vaccine in Patients With Human Papillomavirus HPV-positive Oropharyngeal Cancer
Status: RECRUITING
Conditions: Head and Neck Carcinoma|Adult Disease
Interventions: BIOLOGICAL: HPVDC injection level dose 1|BIOLOGICAL: placebo injection level dose 1|BIOLOGICAL: HPVDC injection level dose 2|BIOLOGICAL: placebo injection level dose 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Short-term Outcomes of Full Bowel Preparation (MBP+OA) for Colon Cancer Resections Versus no Bowel Preparation
Status: RECRUITING
Conditions: Colon Cancer
Interventions: PROCEDURE: Full bowel preparation prior to colon resection for cancer|PROCEDURE: No bowel preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a Booster Vaccination With an Adapted Vaccine
Status: ACTIVE_NOT_RECRUITING
Conditions: SARS-CoV2 Infection
Interventions: BIOLOGICAL: PHH-1V81|BIOLOGICAL: Comirnaty Omicron XBB1.5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Adverse Long-term Consequences of Sleep Disordered Breathing: The Ottawa Hospital (TOH) Sleep Database
Status: ACTIVE_NOT_RECRUITING
Conditions: Polysomnography|Sleep Apnea Syndromes|Risk Factors|Prognosis|Restless Legs Syndrome|Periodic Limb Movement Sleep Disorder|Sleep Arousal Disorders|Opioid Use
Interventions: OTHER: No intervention but exposure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pediatric Cardiomyopathy Mutation Analysis
Status: RECRUITING
Conditions: Cardiomyopathies|Dilated Cardiomyopathy|Hypertrophic Cardiomyopathy|Restrictive Cardiomyopathy|Arrhythmogenic Right Ventricular Cardiomyopathy|Left Ventricular Non-compaction Cardiomyopathy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Analysis of Transperineal Versus Transrectal Approaches for MRI-Targeted Biopsy of the Prostate for the Detection and Characterization of Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DEVICE: Artemis™ software system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intralesional Steroid Injection Versus Voice Therapy in Management of Vocal Nodules
Status: RECRUITING
Conditions: Vocal Nodules in Adults
Interventions: DRUG: triamcinolone acetonide injection|BEHAVIORAL: Smith Accent method of voice therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Diet Manipulation on Women in the Curves Program
Status: COMPLETED
Conditions: Diet, Carbohydrate-Restricted
Interventions: OTHER: Control|OTHER: American Heart Association plus exercise|OTHER: Curves Complete - I plus exercise|OTHER: Curves Complete - II plus exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of a Water-soluble Topical Antimicrobial to Silver Sulfadiazine in Partial Thickness Burns
Status: COMPLETED
Conditions: Burn
Interventions: DRUG: water-soluble therapy|DRUG: silver sulfadiazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of AFQ056 in Parkinson's Patients With L-dopa Induced Dyskinesias
Status: COMPLETED
Conditions: Dyskinesias|Parkinson Disease|Movement Disorders|Parkinsonian Disorders
Interventions: DRUG: AFQ056|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brain Stimulation and Hand Training in Children With Hemiparesis
Status: COMPLETED
Conditions: Pediatric Hemiparesis
Interventions: DEVICE: Transcranial Direct Current Stimulation (tDCS)|DEVICE: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic and Clotting Activity Study of FVIII-PEGLip
Status: UNKNOWN
Conditions: Hemophilia A With Inhibitor
Interventions: DRUG: PEGylated Liposome (PEGLip)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endocrowns in Anterior Teeth: Effect of Cementation Protocols and Restorative Materials on the Clinical Performance of the Restorations
Status: COMPLETED
Conditions: Endodontically Treated Teeth|Anterior Teeth
Interventions: OTHER: resin cement containing phosphate ester monomer 10-methacryloyloxydecyl dihydrogen phosphate|OTHER: Non MDP containg resin cement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Asunercept for the Treatment of Patients With Moderate to Severe COVID-19 Disease
Status: TERMINATED
Conditions: COVID-19
Interventions: BIOLOGICAL: Asunercept|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Xerecept Intravenous Dose Escalation in Japanese and Caucasian Volunteers
Status: COMPLETED
Conditions: Edema
Interventions: DRUG: Xerecept 1.0|DRUG: Xerecept 2.0|DRUG: Xerecept 3.0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies
Status: RECRUITING
Conditions: SCID|Omenn's Syndrome|Reticular Dysgenesis|Wiskott-Aldrich Syndrome|Bare Lymphocyte Syndrome|Common Variable Immunodeficiency|Chronic Granulomatous Disease|CD40 Ligand Deficiency|Hyper IgM Syndrome|X-linked Lymphoproliferative Disease|Hemophagocytic Lymphohistiocytosis|Griscelli Syndrome|Chediak-Higashi Syndrome|Langerhan's Cell Histiocytosis
Interventions: DRUG: Alemtuzumab 0.3 mg|DRUG: Cyclophosphamide|DRUG: Busulfan|BIOLOGICAL: Stem Cell Transplantation|DRUG: Fludarabine phosphate 40 mg|DRUG: Melphalan|DRUG: Alemtuzumab 0.2 mg|DRUG: Busulfan|DRUG: Fludarabine phosphate 30 mg|DRUG: MESNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ENLIGHTEN: Establishing Novel Antiretroviral (ARV) Imaging for Hair to Elucidate Non-Adherence
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: DRUG: Maraviroc Pill|DRUG: Dolutegravir Pill|DRUG: Truvada Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Delivery Optimization for Antiretroviral Therapy (The DO ART Study)
Status: COMPLETED
Conditions: HIV|ART
Interventions: OTHER: ART initiation in the home|OTHER: Mobile Van Refill and Monitoring|OTHER: Clinic ART Initiation|OTHER: Clinic ART Refill and Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Isotoxic Intensity Modulated Radiotherapy (IMRT) in Stage III Non Small Cell Lung Cancer (NSCLC) - A Feasibility Study
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: RADIATION: Intensity Modulated Radiotherapy treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, PK, PD, Dosing, and Efficacy of RLS-0071for the Treatment of Hospitalized Patients With Steroid-Refractory Acute Graft-versus-Host Disease
Status: RECRUITING
Conditions: Steroid Refractory GVHD
Interventions: DRUG: RLS-0071
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Camrelizumab Plus Fluzoparib for TP-53 Mutated Endometrial Cancer
Status: RECRUITING
Conditions: Endometrial Carcinoma|TP53 Mutation|Recurrent or Metastatic
Interventions: DRUG: Fluzoparib|DRUG: Camrelizumab|DRUG: paclitaxel (albumin bound)|DRUG: Carboplatin injection|DRUG: Carboplatin|RADIATION: External irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total-Body Irradiation, Fludarabine, and Alemtuzumab Followed By Stem Cell Transplant in Treating Patients With Myeloproliferative Disorder, MS, AML, or CML
Status: TERMINATED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Myelodysplastic Syndromes
Interventions: RADIATION: Total Body Irradiation|DRUG: Fludarabine|DRUG: Campath 1H
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fitness, Hearing and Quality of Life in Older Adults With Hearing Loss. Walk, Talk and Listen for Your Life
Status: COMPLETED
Conditions: Hearing Loss, Functional
Interventions: OTHER: Exercise + health education+ auditory rehabilitation|OTHER: auditory rehabilitation alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Safety Study of Pharmacologic Ascorbate and Ferumoxytol in Addition to Standard of Care Chemoradiation in Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma|Glioblastoma Multiforme
Interventions: DRUG: Ferumoxytol injection|DRUG: Pharmacological ascorbate|RADIATION: External beam radiation therapy|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Overlap Method to Digestive Tract Reconstruction of Totally Laparoscopic Left Colectomy
Status: RECRUITING
Conditions: Colon Neoplasm
Interventions: PROCEDURE: Total laparoscopic with intracorporeal anastomosis by overlap method|PROCEDURE: Laparoscopic-assisted colectomy with extracorporeal anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cannabis THC Potency, Metabolism, and Cognitive Impairment in Young Adults
Status: NOT_YET_RECRUITING
Conditions: Cannabis Use|THC|Marijuana Use|Cognitive Impairment|THC Vaping
Interventions: BEHAVIORAL: 15% THC Potency Reduction|BEHAVIORAL: 35% THC Potency Reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Serial Gut Microbiome and Bacterial Gene Markers Changes After Endoscopic Resection of Colorectal Advanced Neoplasia
Status: RECRUITING
Conditions: Colorectal Cancer|Colorectal Neoplasms|Colorectal Adenoma
Interventions: DIAGNOSTIC_TEST: Bacterial gene markers test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Biphasic Insulin Aspart 30 Versus Insulin Glargine Both in Combination With Metformin and Glimepiride in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart|DRUG: insulin glargine|DRUG: metformin|DRUG: glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effiacy and Safety of HIP0612 in Patients With Gastric Ulcer
Status: NOT_YET_RECRUITING
Conditions: Gastric Ulcer
Interventions: DRUG: HIP0612|DRUG: HPP2202|DRUG: RLD2204|DRUG: HPP2201
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 11C-PIB PET/CT in Patients With Parkinson's Disease and Parkinsonian Dementia Syndromes
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: DRUG: 11C-PiB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Acetazolamide for Treatment Resistant Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia|Schizo Affective Disorder
Interventions: DRUG: Acetazolamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasonography Biofeedback for Diaphragm Training in Athletes With Lumbo-pelvic Pain
Status: UNKNOWN
Conditions: Ultrasonography|Low Back Pain
Interventions: OTHER: Experimental|OTHER: Active comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Autologous Tumor-Infiltrating Lymphocytes in Pediatric, Adolescent, and Young Adult Participants
Status: RECRUITING
Conditions: Soft Tissue Sarcoma|Primary Central Nervous System Carcinoma|Melanoma|Rhabdomyosarcoma|Ewing Sarcoma
Interventions: BIOLOGICAL: LN-145/LN-144
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT