pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluation of the Long-term Safety and Tolerability of Metoprolol Versus Nebivolol in Patients With Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Nebivolol (NEB)|DRUG: Metoprolol (MET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project EARLY: Engagement, Assessment, Referral, & Linkage for Young Children
Status: COMPLETED
Conditions: Autism|Developmental Delay Disorders
Interventions: BEHAVIORAL: Family Navigation|BEHAVIORAL: Conventional Care Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Evaluate the Effects of Colesevelam on Insulin Sensitivity and ß-Cell Function in Subjects With Impaired Fasting Glucose (Prediabetes)
Status: COMPLETED
Conditions: Impaired Fasting Glucose|Prediabetes
Interventions: DRUG: Colesevelam|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dose-Response Curve: Interventions to Prevent and Treat Radiodermatitis
Status: COMPLETED
Conditions: Radiodermatitis
Interventions: DRUG: Urea Dose A|DRUG: Urea Dose B|DRUG: Urea Dose C|DRUG: Chamomile Dose A|DRUG: Chamomile Dose B|DRUG: Chamomile Dose C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Behavioral Modification and Vesicare Versus Vesicare Alone for Urge Incontinence in Patients With Overactive Bladder
Status: TERMINATED
Conditions: Overactive Bladder
Interventions: DRUG: Vesicare (solifenacin)|BEHAVIORAL: Vesicare (solifenacin) plus behavioral modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Pembrolizumab (MK-3475) Versus Placebo as Adjuvant Therapy in Participants With Hepatocellular Carcinoma (HCC) and Complete Radiological Response After Surgical Resection or Local Ablation (MK-3475-937 / KEYNOTE-937)
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Caecal pH as a Biomarker for Irritable Bowel Syndrome
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Linaclotide|DIETARY_SUPPLEMENT: FODMAP diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Crizanlizumab for Treating COVID-19 Vasculopathy
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Crizanlizumab|OTHER: 0.9% saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Continuous Heart Rate Monitoring in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Propranolol|DRUG: Pseudoephedrine|DEVICE: Wearable Biosensor Patch Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tenofovir Monotherapy in Patients With Chronic Hepatitis B Patients Who Had Achieved Complete Viral Suppression on Lamivudine Plus Adefovir
Status: UNKNOWN
Conditions: Proportion of Patients With a Sustained Virological Response (Serum HBV DNA <20 IU/mL) at Week 48
Interventions: DRUG: lamivudine plus adefovir combination|DRUG: Tenofovir Disoproxil Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heart and Blood Pressure Study: The Effect of Aortic Impedance on Myocardial Relaxation
Status: COMPLETED
Conditions: High Blood Pressure
Interventions: DRUG: oral hydralazine and intravenous nesiritide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Role of Metformin on Muscle Health of Older Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Muscle Atrophy|Insulin Resistance
Interventions: DRUG: Metformin (Bed Rest)|DRUG: Placebo (Bed Rest)|DRUG: Metformin (2 week run-in only)|DRUG: Placebo (2 week run-in only)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of the Effectiveness of USG and Palpation Guidance Steroid Injection in Patients With Plantar Fasciitis
Status: COMPLETED
Conditions: Plantar Fasciitis
Interventions: DRUG: USG-guided steroid injection|DRUG: Palpation-guided steroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Leukocyte- and Platelet Rich Fibrin (L-PRF) Application in Impacted Mandibular Third Molar Removal Surgery
Status: UNKNOWN
Conditions: Pain|Edema|Wound Heal
Interventions: PROCEDURE: Leukocyte- and platelet rich fibrin|PROCEDURE: Blood clot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Palifosfamide Tris Plus Doxorubicin Versus Doxorubicin in Unresectable or Metastatic Soft-tissue Sarcoma
Status: UNKNOWN
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: Palifosfamide Tris and Doxorubicin|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Managing Time With Dementia: Effects of Time Assistive Products in People With Dementia
Status: ACTIVE_NOT_RECRUITING
Conditions: Dementia
Interventions: OTHER: Time assistive products|OTHER: Information brochure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Benefit and Harm of Fever Suppression by Antipyretics in Influenza
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: Paracetamol|DRUG: Placebo|DRUG: Backup NSAID ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Oral Honey and Water Up to Two Hours Before Surgery on Postoperative Nausea and Vomiting
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DIETARY_SUPPLEMENT: Honey and water mixture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of the Food Supplement TOTUM-070 on Lipid Metabolism
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: TOTUM-070|DIETARY_SUPPLEMENT: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Patients With Acl Injury and Varus Knee Will Undergo Acl Reconstruction Alone, or Combined With High Tibial Osteotomy in the Same Session.
Status: COMPLETED
Conditions: ACL - Anterior Cruciate Ligament Deficiency|Varus Deformity of Tibia (Disorder)|ACL Injury|Knee Deformity
Interventions: PROCEDURE: medial opening wedge high tibial osteotomy|PROCEDURE: anterior cruciate ligament reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Core Stabilization Exercise Program Among Amateur Artistic Gymnasts
Status: COMPLETED
Conditions: Therapy, Exercise|Physical Fitness
Interventions: OTHER: Gymnastic and Core Stabilization|OTHER: Only Gymnastic Training|OTHER: Sedentary Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid Versus Epinephrine During Exploratory Tympanotomy
Status: COMPLETED
Conditions: Intraoperative Bleeding
Interventions: DRUG: Tranexamic Acid|DRUG: Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Bowen Therapy for Pain Management in Patients With Fibromyalgia
Status: UNKNOWN
Conditions: Fibromyalgia
Interventions: OTHER: Conventional|PROCEDURE: Bowen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of VGX-3100 and Electroporation Alone or in Combination With Imiquimod for the Treatment of HPV-16 and/or HPV-18 Related Vulvar HSIL (Also Referred as: VIN 2 or VIN 3)
Status: COMPLETED
Conditions: Vulvar High Grade Squamous Intraepithelial Lesion (HSIL)|Vulvar Dysplasia|Vulvar Intraepithelial Neoplasia (VIN)|VIN2|VIN3|Pre-cancerous Lesions of the Vulva|Human Papillomavirus (HPV)
Interventions: BIOLOGICAL: VGX-3100|DRUG: Imiquimod 5% Cream|DEVICE: CELLECTRA™ 2000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Viral Variants Involved in the Transmission of Hepatitis C and Characterization of Antigenic and Functional Properties of Their Envelope Glycoproteins
Status: COMPLETED
Conditions: Hepatitis C
Interventions: PROCEDURE: Blood sample (act specific of blood withdrawal for the study)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Supplement Intake in Infertile Men;the Effect on Sperm Parameters,Fertilization Rate and Embryo Quality
Status: UNKNOWN
Conditions: Oligospermia
Interventions: DIETARY_SUPPLEMENT: Vitamale
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Phase III Study of BKM120/Placebo With Fulvestrant in Postmenopausal Patients With Hormone Receptor Positive HER2-negative Locally Advanced or Metastatic Breast Cancer Refractory to Aromatase Inhibitor
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Fulvestrant|DRUG: BKM120|DRUG: BKM120 matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acalabrutinib-Lenalidomide-Rituximab in Patients With Untreated MCL
Status: ACTIVE_NOT_RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Acalabrutinib|DRUG: Lenalidomide|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serotonin, Anxiety and Visceral Sensation
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Citalopram 20mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Effectiveness Evaluation of the Sinusway Device for Endoscopy of the Nasal Cavity and Paranasal Sinuses
Status: COMPLETED
Conditions: Sinusitis
Interventions: DEVICE: 3NT flexible endoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of a Home Based Walking Program Using Rhythmic Auditory Stimulation in Patients With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Ambulation Difficulty
Interventions: OTHER: Rhythmic Auditory Stimulation (RAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effect of BONISTEIN(R) Bone Blend on Bone Mineral Density/Content and Biomarkers of Bone Health
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DIETARY_SUPPLEMENT: BONISTEIN(R) bone blend|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MIND Diet to Improve Cognitive Function in Mild Stroke Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Dementia|Cognitive Change|Stroke|Cerebral Infarction|Transient Ischemic Attack
Interventions: BEHAVIORAL: MIND diet intervention|BEHAVIORAL: General dietary advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoantigen Derived DCs as Cancer Treatment
Status: RECRUITING
Conditions: Refractory Tumor|Solid Tumor
Interventions: BIOLOGICAL: Dendritic Cell Vaccine|DRUG: Lenvatinib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperbilirubinemia and Retinopathy of Prematurity in Preterm Infants: a Retrospective Study.
Status: NOT_YET_RECRUITING
Conditions: ROP|Jaundice, Neonatal|Premature|Very Low Birth Weight Infant|ELBW - Extremely Low Birth Weight Infant|Blindness
Interventions: OTHER: ROP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open-Label Safety, PK, and Efficacy Trial of Sebetralstat (KVD900) in Pediatric Patients (Ages 2-11) With HAE Type I or II
Status: RECRUITING
Conditions: Hereditary Angioedema
Interventions: DRUG: KVD900 75 mg|DRUG: KVD900 150 mg|DRUG: KVD900 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Cognitive Rehabilitation for Amnestic Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Cognitive Impairment
Interventions: BEHAVIORAL: 1-face-to-face|BEHAVIORAL: 2-tele rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: YMCA Diabetes Prevention Program for the Treatment of Nonalcoholic Fatty Liver Disease (NAFLD)
Status: COMPLETED
Conditions: Weight Loss|NAFLD|Liver Diseases
Interventions: BEHAVIORAL: YMCA class
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: WOOP VA: Promoting Weight Management in Primary Care
Status: RECRUITING
Conditions: Obesity
Interventions: BEHAVIORAL: mental contrasting with implementation intentions|BEHAVIORAL: telephone-delivered, telehealth-delivered, and or in-person MOVE! or TeleMOVE!|BEHAVIORAL: Information About Diet, Physical Activity, and Weight Management (Baseline Visit - 10 minutes): All|BEHAVIORAL: Telephone MCII Check-ins (30 minutes at 3 days, 4 weeks, and 2 months after baseline visit)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of Fabrazyme (Agalsidase Beta) as Compared to Placebo in Patients With Advanced Fabry Disease
Status: COMPLETED
Conditions: Fabry Disease
Interventions: BIOLOGICAL: Fabrazyme (agalsidase beta)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term Minor Sibling Donor Well-Being
Status: TERMINATED
Conditions: Disorder Related to Bone Marrow Transplantation|Blood Stem Cell Transplant Failure|Disturbance of Emotions Specific to Childhood and Adolescence|Transmission, Blood, Recipient/Donor|Sibling
Interventions: BEHAVIORAL: Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Calcium and Gut Hormones
Status: COMPLETED
Conditions: Obesity|Diabetes
Interventions: DIETARY_SUPPLEMENT: Control|DIETARY_SUPPLEMENT: Milk mineral supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Multicenter Study on the Efficacy and Safety of Favipiravir for Parenteral Administration Compared to Standard of Care in Hospitalized Patients With COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Favipiravir|DRUG: Favipiravir|DRUG: Remdesivir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety, Tolerability and Preliminary Pharmacokinetics and Pharmacodynamics of MYK-461
Status: COMPLETED
Conditions: Hypertrophic Cardiomyopathy
Interventions: DRUG: MYK-461
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Infranodal Conduction Time During TAVR as Predictor of HAVB
Status: UNKNOWN
Conditions: Severe Aortic Valve Stenosis|High-degree AV Block|Left Bundle-Branch Block
Interventions: DIAGNOSTIC_TEST: Limited electrophysiologic study including measurements of HV- and AH-intervals pre- and post-TAVR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Continuous Versus Single-Shot Adductor Canal Block in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Continuous Bupivacaine via Adductor Canal Saphenous Catheter|OTHER: Single Shot Adductor Canal Saphenous Block with Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effectiveness of Two Treatment Strategies for Tension-type Headache
Status: WITHDRAWN
Conditions: Tension-type Headache
Interventions: BEHAVIORAL: Behavioral therapy, splint therapy and physical therapy|DRUG: Standard care using current drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Race, Natriuretic Peptides and Physiological Perturbations
Status: COMPLETED
Conditions: Healthy|Pre Hypertension
Interventions: OTHER: Exercise capacity VO2 max determination|DIETARY_SUPPLEMENT: Standardized meals|OTHER: Exercise challenge|DRUG: Metoprolol Succinate ER
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients
Status: COMPLETED
Conditions: Covid19|SARS-CoV-2 Infection|Pneumonia|Copd|CKD|Cardiac Event|Overweight and Obesity|Cardiovascular Diseases|Diabetes|Hypertension|Coronary Heart Disease
Interventions: OTHER: non-interventional
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Beverages Containing Different Doses of Alginate Fibers on Appetite, Energy Intake and Glycemia
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Alginate dietary fiber|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tetra PICASSO AD Trial: Study to Evaluate Effects of BPN14770 in Early Alzheimer's Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer's Disease
Interventions: DRUG: BPN14770|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomodulating Rotator Cuff Healing - A Proof of Concept Trial
Status: RECRUITING
Conditions: Rotator Cuff Tears
Interventions: OTHER: Biomodulation (non-pharmacological)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Helicobacter Rescue Therapy With Vonorazon and Amoxicillin Dual Therapy Versus Bismuth-containing Quadruple Therapy
Status: RECRUITING
Conditions: Gastritis Dyspepsia Helicobacter Pylori Infection Gastric Cancer Peptic Ulcer
Interventions: DRUG: Vonoprazan|DRUG: amoxicillin|DRUG: Bismuth|DRUG: Esomeprazole|DRUG: Tetracycline|DRUG: Furazolidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of mRNA-1944 in Healthy Adults
Status: COMPLETED
Conditions: Prevention of Chikungunya Virus Infection
Interventions: BIOLOGICAL: mRNA-1944|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial of Nivolumab With FOLFOX After Chemoradiation in Rectal Cancer Patients
Status: RECRUITING
Conditions: Rectal Cancer
Interventions: DRUG: Capecitabine|RADIATION: Radiation therapy|DRUG: mFOLFOX6|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effects of Multiple-Dose Probenecid on the Multiple-Dose Pharmacokinetics of Canagliflozin in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Canagliflozin/Probenecid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Antioxidant Probiotic Administration on Seminal Quality and Reproductive Outcomes.
Status: RECRUITING
Conditions: Male Infertility
Interventions: DIETARY_SUPPLEMENT: Experimental - Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Gemcitabine and Cyberknife Radiation Therapy for Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: RADIATION: Cyberknife radiation and gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cranial Osteopathic Techniques on the Symptoms of Benign Paroxysmal Positional Vertigo
Status: COMPLETED
Conditions: Benign Paroxysmal Positional Vertigo
Interventions: OTHER: The cranial osteopathic techniques|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of UCB0942 in Healthy Japanese and Caucasian Subjects
Status: COMPLETED
Conditions: Healthy Japanese and Caucasian Subjects
Interventions: DRUG: UCB0942|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Head-to-head Comparison of Virtual Reality Treatment for Post Traumatic Stress Disorder
Status: UNKNOWN
Conditions: Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: Virtual Reality Exposure Therapy - Dynamic|BEHAVIORAL: Augmented Exposure Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rituximab in Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis
Interventions: DRUG: Rituximab|DRUG: Placebo (NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact on the Intestinal Microbiota of Treatment With Ceftriaxone in Women's Acute Community Pyelonephritis
Status: COMPLETED
Conditions: Pyelonephritis Acute
Interventions: DRUG: Ceftriaxone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Post-surgical Outcomes With Anabolic Agent Use in High-risk Ankle Fractures: A Pilot RCT
Status: NOT_YET_RECRUITING
Conditions: Ankle Fractures
Interventions: DRUG: subcutaneous Teriparatide injection|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL343 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: DNL343|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Real World Evaluation of Lifelight®: A Contactless Vital Signs Monitor for Self-monitoring Blood Pressure and Its Comparison to Standard of Care
Status: NOT_YET_RECRUITING
Conditions: Hypertension
Interventions: DEVICE: Lifelight|DEVICE: Blood Pressure Cuff
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Patient-ventilator Asynchrony During Noninvasive Ventilation Assessed Using Diaphragm Ultrasonography
Status: UNKNOWN
Conditions: Diaphragm|Ultrasonography
Interventions: OTHER: Creation and detection of patient-respirator asynchronies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: AssessMent and Counseling to Get the Best Efficiency and Effectiveness of the Assistive TeCHnology
Status: TERMINATED
Conditions: Disability Physical|Disability, Learning|Disabling Disease
Interventions: OTHER: Initial Assessment|OTHER: Implementation of assistive technology in the daily life of participants|OTHER: Application of outcome measures
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Hip Denervation and Intra-articular Hydration in Damaged Hip in Axial Spondyloarthritis Patients
Status: COMPLETED
Conditions: Patients With Axial SpA According to ASAS Criteria|Patients With Unilateral or Bilater Hip Damage According to BASRI Score|Age > 18
Interventions: DRUG: hip denervation|DRUG: intra-articular hydration|DRUG: Combined group|DRUG: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Management of Loading Forces Distribution in Mandibular Distal-extension Prostheses
Status: COMPLETED
Conditions: Mandibular Distal-extension Prostheses
Interventions: PROCEDURE: Altered cast technique|DEVICE: Precision Attachments|PROCEDURE: Resilient layer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pinometostat With Standard Chemotherapy in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia and MLL Gene Rearrangement
Status: TERMINATED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Cytarabine|DRUG: Daunorubicin|DRUG: Daunorubicin Hydrochloride|DRUG: Pinometostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Vitamin D Treatment on Multi-systemic Functions in Young Men With Vitamin D Deficiency Due to Work Conditions
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metacognitive Therapy for Post-concussive Symptoms After Mild Traumatic Brain Injury
Status: COMPLETED
Conditions: Brain Injuries|Post-Concussive Symptom|Post-Concussive Syndrome
Interventions: BEHAVIORAL: Metacognitive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relate Tooth Alveolar Extraction Socket Anatomy to Alveolar Remodeling Rate
Status: UNKNOWN
Conditions: Loss of Teeth Due to Extraction|Alveolar Bone Loss|Bone Resorption
Interventions: PROCEDURE: Tooth Extraction|RADIATION: Cone-Beam technology evaluation|OTHER: Measure Alveolar Socket Remodeling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Thin Film Spectacle Coatings to Reduce Light Sensitivity and Headaches in Patients With Migraine
Status: COMPLETED
Conditions: Migraine Disorders|Photophobia
Interventions: OTHER: Therapeutic Lens Coating|OTHER: Sham Lens Coating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The SUPPORT Study: Effectiveness and Usability of a Web-Enabled Resource for Postpartum Mental Health
Status: COMPLETED
Conditions: Postpartum Depression|Postpartum Anxiety|Postnatal Depression|Perinatal Disorder|Perinatal Depression|Postpartum Disorder
Interventions: OTHER: Postpartumcare.ca (Web-Enabled Intervention)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduction of Neonatal Parenteral Nutrition Associated Cholestasis Through Lipid Emulsions
Status: TERMINATED
Conditions: Intrahepatic, Cholestasis
Interventions: OTHER: SMOFlipid|OTHER: Lipofundin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of CPAP Treatment on Arterial Stiffness in Patients With T2DM and Newly Diagnosed Obstructive Sleep Apnoea
Status: UNKNOWN
Conditions: Diabetes|Obstructive Sleep Apnea
Interventions: DEVICE: CPAP|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Red-Rubber Catheter to Facilitate Nasotracheal Intubation in Adult Patients
Status: COMPLETED
Conditions: Intubation;Difficult
Interventions: DEVICE: Red Rubber Catheter|DEVICE: Standard nasal tracheal Intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study to Compare Capecitabine + Bevacizumab Versus Capecitabine, Concomitantly With Radiotherapy as Neoadjuvant Treatment for Patients With Localized and Resectable Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DRUG: Bevacizumab + Capecitabine + Radiotherapy|DRUG: Capecitabine + Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy, Safety and Pharmacokinetic of Octafibrin in Paediatric Subjects With Fibrinogen Deficiency
Status: COMPLETED
Conditions: Congenital Fibrinogen Deficiency
Interventions: BIOLOGICAL: Octafibrin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictors Affecting Long-term Use of Solifenacin or Mirabegron in Women With Overactive Bladder Syndrome
Status: RECRUITING
Conditions: Overactive Bladder Syndrome
Interventions: DRUG: Solifenacin Oral Tablet|DRUG: Mirabegron 25mg
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mirtazapine Plus Gemcitabine Versus Gemcitabine in Metastasis Pancreatic Cancer
Status: WITHDRAWN
Conditions: Pancreatic Cancer
Interventions: DRUG: Mirtazapine plus gemcitabine|DRUG: Gemcitabine, placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Research Study Looking at How Well a Combination of the Medicines Semaglutide and NNC0480-0389 Works in People With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: NNC0480-0389|DRUG: Semaglutide|DRUG: Placebo (NNC080-0389)|DRUG: Placebo (semaglutide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 68 Ga-NODAGA-E[c(RGDγK)]2: Positron Emission Tomography Tracer for Imaging of Myocardial Angiogenesis
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: 68Ga-NODAGA-E[c(RGDyK)]2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: [Lu-177]Ludotadipep in Castration-resistant Prostate Cancer(CRPC): Investigation of Drug and Application_2
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer, mCRPC
Interventions: DRUG: [177Lu]Ludotadipep
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposome Encapsulated Docetaxel (LE-DT) in Patients With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: LE-DT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online Psychoeducation for Intolerance of Uncertainty
Status: COMPLETED
Conditions: Intolerance of Uncertainty|Anxiety
Interventions: BEHAVIORAL: Active IU-focused Psychoeducation Intervention|BEHAVIORAL: Health-focused Psychoeducation Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison Study of WBRT and SRS Alone Versus With Temozolomide or Erlotinib in Patients With Brain Metastases of NSCLC
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung|Neoplasm Metastasis
Interventions: DRUG: Erlotinib, Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients
Status: COMPLETED
Conditions: Vitamin C Deficiency|Smoking|Surgery|Surgery--Complications|Wound|Wound Complication|Wound Infection|Wound Dehiscence|Wound of Skin|Mandible Fracture|Mandible Open Fracture|Mandible Closed Fracture|Mandibular Fractures|Ascorbic Acid Deficiency|Oxidative Stress|Inflammation
Interventions: DIETARY_SUPPLEMENT: Vitamin C|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Titanium vs Absorbable Tacks for Mesh Fixation in Laparoscopic Incisional and Ventral Hernia Repair
Status: UNKNOWN
Conditions: Ventral Hernia|Incisional Hernia
Interventions: PROCEDURE: Laparoscopic incisional or ventral hernia repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repetitive Magnetic Transcranial Stimulation (rTMS) in the Treatment of Generalized Anxiety Disorder (GAD)
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: PROCEDURE: Repetitive transcranial magnetic stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Randomized, Controlled Clinical Study of BET Combined With Tympanostomy Tube Insertion in the Treatment of Intractable OME After Radiotherapy for NPC
Status: UNKNOWN
Conditions: Otitis Media With Effusion After Nasopharyngeal Carcinoma
Interventions: PROCEDURE: Balloon Eustachian Tuboplasty with Tympanostomy Tube Insertion|PROCEDURE: Tympanostomy Tube Insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of OHP in Improving Self-efficacy in Patients With Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus|Chronic Illness
Interventions: BEHAVIORAL: Optimal Health Program|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: S9911, Combination Chemotherapy Plus Monoclonal Antibody Therapy in Treating Patients With Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: CHOP regimen|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: prednisone|DRUG: vincristine sulfate|RADIATION: tositumomab and iodine I 131 tositumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase IIb Study to Evaluate the Safety of Zibotentan/Dapagliflozin in Participants With Cirrhosis-ZEAL-UNLOCK
Status: RECRUITING
Conditions: Liver Cirrhosis
Interventions: DRUG: Placebo (placebo matching zibotentan capsule and placebo matching dapagliflozin tablet)|DRUG: Zibotentan + placebo (placebo matching dapagliflozin tablet)|DRUG: Zibotentan + dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Estimation of the ED95 of Intrathecal Hyperbaric Prilocaine 2% With Sufentanyl for Scheduled Cesarean Delivery
Status: COMPLETED
Conditions: Pregnant Women
Interventions: DRUG: HB Prilocaine 2% (varying dose)|DRUG: HB Prilocaine 2%|DRUG: Sufentanil|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Stem Cell Therapy in Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: BIOLOGICAL: Cardiology Stem Cell Centre Adipose Stem Cell (CSCC_ASC)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Open-label Study of Surufatinib in Japanese Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Neuroendocrine Tumors|Non-hematologic Malignancy
Interventions: DRUG: Surufatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sintilimab Combined With Fruquintinib/Regorafenib ± Radiotherapy for Third-line Treatment of Advanced Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer|Immunotherapy|Radiotherapy|Targeted Therapy
Interventions: DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caregiver Burden of Wet Age-related Macular Degeneration (wAMD) in Japan
Status: COMPLETED
Conditions: Wet Macular Degeneration
Interventions: DRUG: Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial of Efficacy and Safety of ММН-407 in Acute Respiratory Viral Infection
Status: COMPLETED
Conditions: Viral Respiratory Infection
Interventions: DRUG: MMH-407|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Investigate the Bioequivalence of Norditropin® (Somatropin) Versus Genotropin® (Somatropin) in Healthy Adult Subjects
Status: COMPLETED
Conditions: Growth Disorder|Healthy
Interventions: DRUG: Norditropin® FlexPro® pen|DRUG: Genotropin Pen®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of FURESTEM-RA Inj. in Patients With Moderate to Severe Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: FURESTEM-RA Inj|OTHER: sterile saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Tirapazamine in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: paclitaxel|DRUG: tirapazamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effect of LSD on Neural Synchrony, Prosocial Behavior, and Relationship Quality
Status: RECRUITING
Conditions: Prosocial Behavior
Interventions: DRUG: LSD|DRUG: Ethanol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Investigation of Brain Mechanisms Involved in Urgency Urinary Incontinence
Status: RECRUITING
Conditions: Urgency Urinary Incontinence
Interventions: DRUG: Trospium|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Partial Breast Irradiation With Multi-Catheter Brachytherapy for pT1-2pN0 Breast Cancer After Breast Conserving Surgery
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: Accelerated partial breast irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Androgen Receptor Antagonist ARN-509 With or Without Abiraterone Acetate, Gonadotropin-Releasing Hormone Analog, and Prednisone in Treating Patients With High-Risk Prostate Cancer Undergoing Surgery
Status: RECRUITING
Conditions: Stage II Prostate Adenocarcinoma|Stage III Prostate Adenocarcinoma
Interventions: DRUG: Abiraterone Acetate|DRUG: Androgen Receptor Antagonist ARN-509|BIOLOGICAL: Gonadotropin-releasing Hormone Analog|DRUG: Prednisone|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Radical Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Orthokeratology Versus Spectacles on Myopia Progression in Chinese Children: A Crossover Trial
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Orthokeratology|DEVICE: Spectacle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial Comparing Standard Versus Positive Pressure Nebulization in Infants With Bronchiolitis to Reduce Hospital Admissions
Status: UNKNOWN
Conditions: Bronchiolitis
Interventions: DEVICE: Positive Airway Pressure nebulization|DEVICE: Standard passive nebulization of respiratory medications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of Herceptin (Trastuzumab) in Patients With Metastatic or Advanced Gastric Cancer With Disease Progression
Status: TERMINATED
Conditions: Gastric Cancer
Interventions: DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Effects of Lumbal Stabilization Exercises and Connective Tissue Massage on Neuropathic Pain, Functional Capacity and Quality of Life
Status: COMPLETED
Conditions: Peripheral Neuropathy
Interventions: OTHER: Physical therapy and rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation Using Conventional Laryngoscope Versus C-MAC Video Laryngoscope in Patients Undergoing Elective Coronary Artery Bypass Grafting (CABG) Surgery
Status: UNKNOWN
Conditions: Intubation Complication
Interventions: DEVICE: Endotracheal intubation using a laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Techniques in Determining Femoral Veins Location
Status: COMPLETED
Conditions: Vascular Access Complication
Interventions: PROCEDURE: femoral vein identification|PROCEDURE: femoral vein identification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The COLIC Study: Colonization of the Infant Gut With B. Infantis EVC001 to Reduce Symptoms of Colic
Status: TERMINATED
Conditions: Infantile Colic
Interventions: DIETARY_SUPPLEMENT: B. infantis EVC001 or Lactose Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT