pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: First-into-human Study of NS-136 in Healthy Subjects
Status: RECRUITING
Conditions: Healthy Subjects
Interventions: DRUG: Placebo|DRUG: NS-136 tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Studying Protein Expression in Tissue Samples From Younger Patients With Rhabdomyosarcoma
Status: COMPLETED
Conditions: Alveolar Childhood Rhabdomyosarcoma|Embryonal Childhood Rhabdomyosarcoma|Previously Treated Childhood Rhabdomyosarcoma|Previously Untreated Childhood Rhabdomyosarcoma|Recurrent Childhood Rhabdomyosarcoma
Interventions: OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of Noninvasive Methods to Identify Patients at Risk of Serious Arrhythmias After a Heart Attack
Status: COMPLETED
Conditions: Myocardial Infarction|Death, Sudden, Cardiac|Death
Interventions: PROCEDURE: Spectral T Wave Alternans|PROCEDURE: Modified Moving Average T Wave Alternans|PROCEDURE: Baroreceptor Sensitivity|PROCEDURE: Heart Rate Variability|PROCEDURE: Heart Rate Turbulence|PROCEDURE: Deceleration Capacity|PROCEDURE: Signal Averaged ECG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pain Control and Quality of Recovery After Intravenous Methadone Versus Intrathecal Morphine in Major Abdominal Surgery
Status: RECRUITING
Conditions: Pain, Postoperative
Interventions: DRUG: Methadone|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase III Hallmark DUAL: ASV+DCV (Nulls/Partials, Intolerants/Ineligibles. Naives)
Status: COMPLETED
Conditions: Hepatitis C Virus
Interventions: DRUG: Asunaprevir (ASV)|DRUG: Daclatasvir (DCV)|DRUG: Pegylated-interferon alfa 2a (PegIFN)|DRUG: Ribavirin (RBV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study to Evaluate the Safety and Pharmacokinetics of Oral Doses of Anvylic-3288 in Healthy Subjects
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DEVICE: AVL-3288|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Reactogenicity and Immunogenicity of a Venezuelan Equine Encephalitis DNA Vaccine Candidate Administered by Jet Injection
Status: ACTIVE_NOT_RECRUITING
Conditions: Vaccine Reaction
Interventions: DRUG: Venezuelan Equine Encephalitis DNA Vaccine|DEVICE: PharmaJet Stratis Needle-free Injection System|DEVICE: PharmaJet Tropis Needle-free Injection System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of TAK-755 in Participants With Congenital Thrombotic Thrombocytopenic Purpura
Status: RECRUITING
Conditions: Thrombotic Thrombocytopenic Purpura (TTP)
Interventions: BIOLOGICAL: TAK-755
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Cold Sore Treatments on Ultra Violet (UV) Induced Cold Sores
Status: COMPLETED
Conditions: Oral Herpes Simplex
Interventions: DRUG: Matching Placebo|DRUG: BTL-TML-HSV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: WI231696: Bosutinib, Palbocicilib and Fulvestrant for HR+HER2- Advanced Breast Cancer Refractory to a CDK4/6 Inhibitor
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Breast Cancer|Human Epidermal Growth Factor 2 Negative Carcinoma of Breast|Hormone Receptor Positive Breast Cancer
Interventions: DRUG: Palbociclib|DRUG: Bosutinib|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of WP1220 for the Treatment of Adult Subjects With Cutaneous T-Cell Lymphoma (CTCL)
Status: COMPLETED
Conditions: Cutaneous T-Cell Lymphoma/Mycosis Fungoides
Interventions: DRUG: WP1220
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Free Fatty Acids (FFA) on Androgen Precursors in Women
Status: COMPLETED
Conditions: Hyperandrogenism|Glucocorticoid Metabolism
Interventions: DRUG: lipid/heparin infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Treatment of Insomnia Comorbid With Sleep Disordered Breathing Using Armodafinil and/or Cognitive Behavioral Therapy for Insomnia
Status: COMPLETED
Conditions: Sleep Apnea|Insomnia
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia|DRUG: Armodafinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety of Intraperitoneal (IP) OXAliplatin (OXA) in Association With Systemic FOLFIRI Bevacizumab Chemotherapy in Patients With Peritoneal Carcinosis
Status: UNKNOWN
Conditions: Peritoneal Carcinosis
Interventions: DRUG: intraperitoneal (IP) OXAliplatin (OXA) + systemic FOLFIRI bevacizumab chemotherapy|DRUG: intraperitoneal (IP) OXAliplatin (OXA) + systemic FOLFIRI bevacizumab chemotherapy|DRUG: intraperitoneal (IP) OXAliplatin (OXA) + systemic FOLFIRI bevacizumab chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Perioperative mFOLFOX6 Plus Pembrolizumab in Patients With Potentially Resectable Adenocarcinoma of the Gastroesophageal Junction (GEJ) and Stomach
Status: WITHDRAWN
Conditions: Adenocarcinoma|Stomach Cancer
Interventions: DRUG: mFLOFOX6 + pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Circumflex Nerve Blocks Versus Posterior Cord Nerve Blocks in Shoulder Arthroscopy
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: PROCEDURE: Suprascapular Nerve Block|PROCEDURE: Axillary Nerve Block|PROCEDURE: posterior cord block|PROCEDURE: General anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of a Prognostic Score for Steroid Therapy Response in Acute Severe Autoimmune Hepatitis
Status: NOT_YET_RECRUITING
Conditions: Liver Failure, Acute|Hepatitis, Autoimmune|Organ Dysfunction Scores|Risk Factors
Interventions: OTHER: Corticosteroid therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Effectiveness of Polymethoxy Flavones Solid Dispersion as a Dressing Material for Palatal Grafts Donor Sites
Status: NOT_YET_RECRUITING
Conditions: Soft Tissue Infections|Gingival Recession
Interventions: DRUG: hydroxylate flavones solid dispersion application|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation to Evaluate the Effectiveness and Safety of ECG App
Status: COMPLETED
Conditions: Arrhythmias, Cardiac
Interventions: DEVICE: 12-Lead ECG(I-lead)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Talabostat and Rituximab in Advanced Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Talabostat mesylate (PT-100) tablets|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Severe and Critical COVID-19 Pneumonia With Convalescent Plasma
Status: TERMINATED
Conditions: Covid-19
Interventions: BIOLOGICAL: Anti SARS-CoV 2 Convalescent Plasma in severe COVID-19 patients|BIOLOGICAL: Anti SARS-CoV 2 Convalescent Plasma in critical COVID-19 patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Evonail® Solution for Prevention or Treatment of Onycholysis
Status: COMPLETED
Conditions: Breast Cancer|Docetaxel Chemotherapy
Interventions: DRUG: EVONAIL® solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sirolimus With Tacrolimus for Graft-vs-Host Disease Prophylaxis After Related Stem Cell Transplantation
Status: COMPLETED
Conditions: Hematologic Malignancies|Myelogenous Leukemia|Acute Lymphoblastic Leukemia|Myelodysplastic Syndrome|Non-Hodgkin's Lymphoma|Hodgkin's Disease
Interventions: DRUG: Sirolimus|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: HA-WBRT vs SRS in Patients With Multiple Brain Metastases
Status: UNKNOWN
Conditions: Brain Metastases
Interventions: RADIATION: Hippocampal Avoiding Whole Brain Radiation Therapy with Simultaneous Integrated Boost|RADIATION: Single session or hypofractionated stereotactic radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Early Pancreatic Stent Placement for Preventing PEP
Status: NOT_YET_RECRUITING
Conditions: Cholangiopancreatography, Endoscopic Rretrograde|Post-ERCP Pancreatitis
Interventions: DEVICE: early pancreatic stent placement (EPSP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacodynamic Effects of Sacubitril/Valsartan on Natriuretic Peptides, Angiotensin and Neprilysin
Status: UNKNOWN
Conditions: Heart Failure, Systolic
Interventions: DRUG: Sacubitril / Valsartan Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy Trial
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DRUG: Darapladib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Apremilast in the Treatment of Skin Disease in Patients With Dermatomyositis
Status: TERMINATED
Conditions: Dermatomyositis
Interventions: DRUG: Apremilast
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Drug Eluting Balloon and Drug Eluting Stent
Status: COMPLETED
Conditions: Coronary Artery Disease|Stable Angina|Unstable Angina|NSTEMI
Interventions: DEVICE: Drug eluting balloon + Bare metal stent|DEVICE: drug eluting stent (Zotarolimus-eluting stent)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Circulating Tumor DNA Testing in Predicting Treatment for Patients With Stage IIA Colon Cancer After Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Colon Adenocarcinoma|Stage IIA Colon Cancer AJCC v8
Interventions: DRUG: Capecitabine|DRUG: Fluorouracil|DRUG: Leucovorin|DRUG: Leucovorin Calcium|DRUG: Oxaliplatin|OTHER: Patient Observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Assess Optimized Dosage of Lacosamide as add-on Therapy in Patients With Partial Onset Seizure
Status: COMPLETED
Conditions: Partial Epilepsies
Interventions: DRUG: Lacosamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Family-Implemented Treatment on the Behavioral Inflexibility of Children With Autism
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Repetitive Compulsive Behavior
Interventions: BEHAVIORAL: FITBI|BEHAVIORAL: Parental Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determining Feasibility and Acceptability of Sharing Video Recordings With Patients With ALS and Caregivers
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: OTHER: HealthPAL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy of Sterol-Fortified Low Fat Soy Beverage on Cholesterol Metabolism, Inflammation and Oxidative Status in Humans - Study II
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: plant sterol enriched soymilk|DIETARY_SUPPLEMENT: control dairy milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritional Therapy for Delirium in Elderly Hospitalized Subjects
Status: RECRUITING
Conditions: Subacute Delirium
Interventions: DIETARY_SUPPLEMENT: 260279 active study product|DIETARY_SUPPLEMENT: 260279 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy Study of Herbal Formula CUF2 to Treat Childhood Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: CUF2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Social Networking on Chronic Disease Management in Arthritis
Status: COMPLETED
Conditions: Chronic Disease Management|Rheumatoid Arthritis
Interventions: BEHAVIORAL: Questionnaires|BEHAVIORAL: Facebook|BEHAVIORAL: Educational Website|BEHAVIORAL: Phone Interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Targeted Intervention for Insufficient Sleep Among Typically-Developing Adolescents
Status: COMPLETED
Conditions: Sleep Disturbance
Interventions: BEHAVIORAL: Targeted Approaches for Promoting Adolescent Sleep (TAPAS)|BEHAVIORAL: Sleep Monitoring Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastrointestinal Assessment of Three Novel RS4
Status: COMPLETED
Conditions: Diet Modification
Interventions: OTHER: Resistant Starch Type 4 Supplementation|OTHER: Resistant Starch Type 4 Supplementation|OTHER: Resistant Starch Type 4 Supplementation|OTHER: Digestible Starch Supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate Efficacy and Safety of Hydeal Cyst® Intravesical Instillations in Patients Treated With Intravesical Chemotherapy or Immunotherapy in Non-muscle Invasive Bladder Cancer
Status: NOT_YET_RECRUITING
Conditions: Non-muscle Invasive Bladder Cancer
Interventions: DEVICE: Hydeal Cyst®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thoracic Blocks Versus Thoracic Epidural and Patient Controlled Anesthesia in Traumatic Rib Fracture Patients
Status: COMPLETED
Conditions: Traumatic Rib Fracture
Interventions: PROCEDURE: Paravertebral Block|PROCEDURE: Intercostal Nerve Block|PROCEDURE: Epidural Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Enhancing PTSD Treatment Outcomes by Improving Patient-Provider Communication
Status: NOT_YET_RECRUITING
Conditions: Stress Disorders, Post-Traumatic
Interventions: BEHAVIORAL: Adjunctive writing to amplify response and engagement (AWARE)|BEHAVIORAL: Cognitive processing therapy (CPT)|BEHAVIORAL: Prolonged exposure (PE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Immunogenicity Study of a Clostridium Difficile Toxoid Vaccine in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Clostridium Infections
Interventions: BIOLOGICAL: Placebo (vaccine diluent)|BIOLOGICAL: Clostridium difficile vaccine|BIOLOGICAL: Clostridium difficile vaccine|BIOLOGICAL: Clostridium difficile vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: SR34006 Compared to Vitamin K Antagonist (VKA) in the Treatment of Pulmonary Embolism
Status: COMPLETED
Conditions: Pulmonary Embolism
Interventions: DRUG: SR34006|DRUG: (LMW)heparin|DRUG: Warfarin VKA|DRUG: Acenocoumarol VKA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plasma Adsorption in Patients With Confirmed COVID-19
Status: COMPLETED
Conditions: Respiratory Failure|ARDS
Interventions: DEVICE: Marker Therapeutics D2000 Cartridge (D2000) for use with the Spectra Optia® Apheresis System (Optia SPD Protocol)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient Satisfaction and Bone Changes for OT Cap and OT Vertical Attachment
Status: UNKNOWN
Conditions: Patient Satisfaction|Bone Changes
Interventions: OTHER: OT Vertical attachment|OTHER: OT cap attachment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Minocycline in Acute Spinal Cord Injury (MASC)
Status: UNKNOWN
Conditions: Spinal Cord Injuries
Interventions: DRUG: Minocycline|DRUG: Placebo|PROCEDURE: Surgical spinal cord decompression|PROCEDURE: Maintenance of minimum mean arterial pressure (MAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Tissue Adhesive to Palatal Donor Site Healing.
Status: COMPLETED
Conditions: Donor Site Complication
Interventions: DRUG: Gelatin Sponge;Thrombin, Bovine 5000 IU Multiple Routes Kit [GELFOAM-JMI SPONGE KIT]|DRUG: Cyanoacrylate, Isobutyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase II Study of Novantrone(R) (Mitoxantrone) and Etoposide in Patients With HIV Associated Large Cell and Immunoblastic Lymphomas
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin|HIV Infections
Interventions: DRUG: Mitoxantrone hydrochloride|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of Hypnosis Support on Patient Perception of Outpatient Surgery Under Local Anaesthesia
Status: RECRUITING
Conditions: Hypnosis|Local Anaesthesia|Outpatient Surgery|FACE
Interventions: OTHER: State-Trait Anxiety Inventory ("Spielberger Self-Assessment Questionnaire")|PROCEDURE: hypnosis techniques|PROCEDURE: local anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Equivalence of Estradiol Vaginal Cream to Reference Standard in the Treatment of Vaginal Atrophy
Status: COMPLETED
Conditions: Vulvar and Vaginal Atrophy
Interventions: DRUG: Estrace® Cream|DRUG: Estradiol Vaginal Cream|DRUG: Vehicle Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Platelet Rich Plasma Injection in Diabetic Neuropathy
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathy
Interventions: DRUG: PRP injection|OTHER: traditional medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Proof of Concept Study to Evaluate the Safety of Afamelanotide in Patients With Acute Arterial Ischaemic Stroke (AIS)
Status: COMPLETED
Conditions: Arterial Ischemic Stroke
Interventions: DRUG: Afamelanotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Follow-up Study for Patients Who Completed Study ALX0681-C301 (Post-HERCULES)
Status: COMPLETED
Conditions: Acquired Thrombotic Thrombocytopenic Purpura
Interventions: BIOLOGICAL: Caplacizumab|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of SHR-A1921 Combined With Adebrelimab and SHR-8068 With or Without Carboplatin in the Treatment of Advanced NSCLC
Status: NOT_YET_RECRUITING
Conditions: Advanced Non-small Cell Lung Cancer
Interventions: DRUG: SHR-A1921；Adebrelimab；SHR-8068；carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RRx-001 in Lung Cancer, Ovarian Cancer and Neuroendocrine Tumors Prior to Re-administration of Platinum Based Doublet Regimens (QUADRUPLE THREAT)
Status: COMPLETED
Conditions: Small Cell Carcinoma|Carcinoma, Non-Small-Cell Lung|Neuroendocrine Tumors|Ovarian Epithelial Cancer
Interventions: DRUG: RRx-001|DRUG: Cisplatin|DRUG: Etoposide|DRUG: Carboplatin|DRUG: Irinotecan|DRUG: Vinorelbine|DRUG: Doxil|DRUG: Gemcitabine|DRUG: Taxane|DRUG: Paclitaxel|DRUG: Nab-Paclitaxel|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LPR Fluorescence Pilot
Status: UNKNOWN
Conditions: Laryngopharyngeal Reflux|Gastro Esophageal Reflux
Interventions: DIAGNOSTIC_TEST: 24-hour pH-impedance monitoring|OTHER: Symptom questionnaires|OTHER: ROME IV Diagnostic Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MK-8189 Multiple Dose Study in Healthy Volunteers and Schizophrenia Participants (MK-8189-003)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: MK-8189|DRUG: Placebo|DRUG: Base Monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Prolonged Aerobic exeRcise in Patients With Type 1 Diabetes on Advanced Technologies
Status: COMPLETED
Conditions: Type1diabetes
Interventions: OTHER: Insulin therapy adjustment|OTHER: Nutritional adjustment|OTHER: Combination of strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Status Asthmaticus on the PICU; Intravenous Salbutamol
Status: COMPLETED
Conditions: Childhood Asthma With Status Asthmaticus
Interventions: DRUG: Salbutamol|DRUG: Sodium Chloride 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remineralization Potential of MI Varnish Versus Fluoride Varnish on White Spot Lesions in Maxillary Primary Incisors
Status: COMPLETED
Conditions: Remineralization Effect of the Varnish on White Spot Lesions
Interventions: OTHER: MI varnish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Novel 3D Printed Knee Brace for Medial Knee Osteoarthritis
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: KNEEMO knee brace|DEVICE: Popular knee brace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Correlation of Phonation With Deglutition and Aspiration Risk in the ICU Patients - an Exploratory Study
Status: COMPLETED
Conditions: Aspiration
Interventions: OTHER: Combined speech therapy tools, measures of swallowing function
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Robotic-assisted Therapy With Bilateral Practice Improves Task and Motor Performance of the Upper Extremity for Chronic Stroke Patients
Status: COMPLETED
Conditions: Stroke Rehabilitation
Interventions: OTHER: Robotic-assisted Therapy with Bilateral Practice|OTHER: Unilateral Task-specific Training|OTHER: Sensorimotor Stimulation Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decitabine and Selinexor in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: decitabine|DRUG: selinexor|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Nd:YAG Laser and Air Abrasive Combined Application in Patients With Periodontitis
Status: COMPLETED
Conditions: Periodontitis
Interventions: DEVICE: Air Abrasive|DEVICE: Nd:YAG Laser|PROCEDURE: Non surgical periodontal therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Strengthening Child Social-Emotional and Lifestyle Health in Families Experiencing Stress
Status: RECRUITING
Conditions: Child Behavior|Sedentary Behavior|Self-regulation|Parenting
Interventions: BEHAVIORAL: Family Life Skills Triple P
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vaginal and Rectal Colonization of Lactobacillus Crispatus NTCVAG04 Following Oral Administration in Patients With History of Vaginitis/Vaginosis
Status: COMPLETED
Conditions: Vaginitis|Vaginosis
Interventions: DIETARY_SUPPLEMENT: BIOVAGINIL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Atherosclerotic Cardiovascular Disease
Interventions: DRUG: Placebo|DRUG: Olpasiran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Tranexamic Acid in Facial Fillers
Status: WITHDRAWN
Conditions: Injection Site Bruising
Interventions: DRUG: Tranexamic acid|OTHER: Saline|DRUG: Hyaluronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Percutaneous Endoscopic Tracheal Plug/Unplug for CDH (Congenital Diaphragmatic Hernia)
Status: NO_LONGER_AVAILABLE
Conditions: Severe Congenital Diaphragmatic Hernia
Interventions: DEVICE: Percutaneous endoscopic fetal tracheal occlusion/unocclusion
Study Type: EXPANDED_ACCESS
Clinical trial: Gene Therapy in Preventing Cancer in Patients With Premalignant Carcinoma of the Oral Cavity or Pharynx
Status: COMPLETED
Conditions: Lip and Oral Cavity Cancer|Oropharyngeal Cancer|Stage 0 Lip and Oral Cavity Cancer|Stage 0 Oropharyngeal Cancer|Tongue Cancer
Interventions: BIOLOGICAL: Ad5CMV-p53 gene|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Long-term Safety of Rivastigmine Capsule and Patch in Patients With Mild to Moderately-severe Dementia Associated With Parkinson's Disease (PDD)
Status: COMPLETED
Conditions: Parkinson's Disease Dementia
Interventions: DRUG: Rivastigmine capsule|DRUG: Rivastigmine transdermal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Dose-Ranging Efficacy and Safety Trial of SCH 900271 in Participants With Primary Hypercholesterolemia or Mixed Hyperlipidemia (P05675)
Status: COMPLETED
Conditions: Primary Hypercholesterolemia|Mixed Hyperlipidemia
Interventions: DRUG: SCH 900271 15mg|DRUG: SCH 900271|DRUG: SCH 900271|DRUG: SCH 900271|DRUG: SCH 900271|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tamoxifen in Treatment of Acute Mania
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Tamoxifen Citrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Football Training as a medicine_FIM_UTH
Status: COMPLETED
Conditions: Soccer Training|Body Composition|Physical Activity|Healthy
Interventions: BEHAVIORAL: FIM-1|BEHAVIORAL: FIM-2|BEHAVIORAL: FIM-3|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: the"Fuzheng" Therapy of TCM to Improve the Survival Quality of Early-stage NSCLC by Intervening the CTCs
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer(NSCLC)
Interventions: DRUG: JinFuKang|DRUG: Cisplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: HDS Plus PBPC Transplant Vs 4 More Courses of FrontLine Therapy in Pts With Aggressive NHL in PR After Induction Therapy
Status: COMPLETED
Conditions: High-Grade Lymphomas
Interventions: DRUG: HDS vs ProMECE/CytaBOM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Healing Rate of Leg Wounds Treated With Contact and Noncontact Ultrasound: The VIP Ultrasound Protocol
Status: COMPLETED
Conditions: Chronic Ulcer of Lower Extremity
Interventions: DEVICE: Contact Ultrasound Therapy|DEVICE: Noncontact Ultrasound Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Non-inferiority Study to Evaluate Efficacy, Safety and Tolerability of NEUMOTEROL® 400 and SYMBICORT® Forte in Adults With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: NEUMOTEROL 400 (BFF 400/12 mcg) single capsule inhaler|DRUG: SYMBICORT forte (BFF 320/9mcg) TURBUHALER inhaler|DRUG: NEUMOTEX 400 (Budesonide 400 mcg)|DRUG: Salbutamol 100 mcg pMDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibrutinib in Steroid Refractory Autoimmune Hemolytic Anemia
Status: UNKNOWN
Conditions: AIHA - Warm Autoimmune Hemolytic Anemia
Interventions: DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Right Ventricular Outflow Tract Posterior Septum Pacing" in Predicting Ventricular Outflow Tract Ventricular Tachycardia Origin
Status: RECRUITING
Conditions: Ventricular Outflow Tract Ventricular Arrhythmias|Radio Frequency Catheter Ablation
Interventions: PROCEDURE: Right Ventricular Outflow Tract Posterior Septum Pacing|PROCEDURE: systemic mapping and ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sylimarin, Pyrroloquinoline, Quinone Sodium Salt and Myricetin Assumption Effects
Status: COMPLETED
Conditions: Oxidative Stress|Alcohol Drinking
Interventions: DIETARY_SUPPLEMENT: Si.Pi.Mi product|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dietary Anthocyanins Improve Lipid Metabolism in a Dose - Dependent Manner
Status: COMPLETED
Conditions: Dyslipidemias
Interventions: DRUG: Medox® Anthocyanin capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Prolonged Versus Delayed Laparoscopic Cholecystectomy for Acute Cholecystitis
Status: COMPLETED
Conditions: Acute Cholecystitis
Interventions: PROCEDURE: Laparoscopic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The DIET Trial - Dietetic Intervention in Psoriatic Arthritis
Status: COMPLETED
Conditions: Arthritis, Psoriatic|Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Diet + supplementation|DIETARY_SUPPLEMENT: Diet + placebo|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy With or Without Ganitumab in Treating Patients With Previously Untreated Metastatic Pancreatic Cancer
Status: WITHDRAWN
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: ganitumab|DRUG: fluorouracil|DRUG: irinotecan hydrochloride|DRUG: leucovorin calcium|DRUG: oxaliplatin|OTHER: placebo|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Pilot Trial of a Mind-Body Sexual Well-Being Intervention for Female GI Cancer Survivors
Status: RECRUITING
Conditions: Colorectal Cancer|Anal Cancer|Sexual Dysfunction
Interventions: BEHAVIORAL: Mind-Body Group Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mobile Application for Self-Management of Type 2 Diabetes Mellitus
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DEVICE: mobile application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: COVID-19 Vaccine Messaging, Part 1
Status: COMPLETED
Conditions: Vaccination|COVID-19
Interventions: OTHER: Control message|OTHER: Baseline message|OTHER: Personal freedom message|OTHER: Economic freedom message|OTHER: Self-interest message|OTHER: Community interest message|OTHER: Economic benefit message|OTHER: Guilt message|OTHER: Embarrassment message|OTHER: Anger message|OTHER: Trust in science message|OTHER: Not bravery message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Lipidomics Screening of Celecoxib in ex Vivo Human Whole Blood Assay - Part B
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Celecoxib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Efficacy of Re-treatment With Cimzia® in Subject With Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Certolizumab Pegol (Cimzia®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Broncho-Adventitial Delivery of Paclitaxel to Extend Airway Patency in Malignant Airway Obstruction Patients
Status: COMPLETED
Conditions: Malignant Airway Obstruction Secondary to Non-small Cell Lung Cancer
Interventions: DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sorafenib Tosylate and Bevacizumab in Treating Patients With Advanced Kidney Cancer
Status: COMPLETED
Conditions: Chromophobe Renal Cell Carcinoma|Clear Cell Renal Cell Carcinoma|Papillary Renal Cell Carcinoma|Recurrent Renal Cell Carcinoma|Sarcomatoid Renal Cell Carcinoma|Stage IV Renal Cell Cancer
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Sorafenib Tosylate|OTHER: Pharmacological Study|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Mirtazapine Versus Placebo on Alcohol Consumption in Male Alcohol High Consumers
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: mirtazapine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing Two Different Intensities of an Intervention to Enhance REsilience and to Reduce SupportIve Care Needs in Cancer Patients
Status: COMPLETED
Conditions: Solid Tumor, Adult
Interventions: BEHAVIORAL: RESIL Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Pilot Open Label Clinical Trial to Evaluate the Combined Impact of Two Mobile Health Products on Health Outcomes in Overweight Adults With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: lifestyle modification instructional and motivational sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Novel, Comprehensive Approach to Post-stroke Gait Rehabilitation
Status: RECRUITING
Conditions: CVA (Cerebrovascular Accident)
Interventions: BEHAVIORAL: Step length biofeedback|BEHAVIORAL: Propulsive force biofeedback|BEHAVIORAL: Interlimb asymmetry biofeedback|BEHAVIORAL: Aerobic intensity-based walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pleiotropic Effects of Atorvastatin in High Cardiovascular Risk Patients
Status: COMPLETED
Conditions: Coronary Artery Disease|HMG-CoA Reductase Inhibitor Toxicity|Atherosclerosis|Oxidative Stress|Endothelial Dysfunction
Interventions: DRUG: Atorvastatin, high vs low dose|DRUG: Atorvastatin vs Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Carbetocin Versus Oxytocin Plus Sublingual Misoprostol in the Management of Atonic Postpartum Hemorrhage
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: oxytocin|DRUG: oxytocin plus misoprostol|DRUG: Carbetocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nanogen Pegfilgrastim (Pegcyte) PK/PD Clinical Study in Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Effectiveness of Ezetimibe/Atorvastatin 10 mg/40 mg Combination Tablet Compared to Marketed Ezetimibe 10 mg and Atorvastatin 40 mg Tablets in Participants With High Cholesterol (MK-0653C-190 AM1)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Atorvastatin|DRUG: Ezetimibe|DRUG: Ezetimibe/atorvastatin|DRUG: Placebo to atorvastatin|DRUG: Placebo to ezetimibe|DRUG: Placebo to ezetimibe/atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate LBL-007 in Combination With Tislelizumab Plus Chemotherapy in Participants With Unresectable Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophageal Cancer|Esophageal Squamous Cell Carcinoma|Esophageal Squamous Cell Carcinoma by AJCC V8 Stage
Interventions: DRUG: LBL-007|DRUG: Tislelizumab|DRUG: Chemotherapy Doublet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Time-Restricted Feeding on Fat Loss and Cardiometabolic Risk Factors in Overweight Adults
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Early Time-Restricted Feeding|BEHAVIORAL: Control Schedule|BEHAVIORAL: Structured Weight Loss Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myeloma-Developing Regimens Using Genomics (MyDRUG)
Status: UNKNOWN
Conditions: Relapsed Refractory Multiple Myeloma
Interventions: DRUG: Abemaciclib, dexamethasone, ixazomib, pomalidomide|DRUG: Enasidenib, dexamethasone, ixazomib, pomalidomide|DRUG: Cobimetinib, dexamethasone, ixazomib, pomalidomide|DRUG: Erdafitinib, dexamethasone, ixazomib, pomalidomide|DRUG: Venetoclax, dexamethasone, ixazomib, pomalidomide|DRUG: Daratumumab, dexamethasone, ixazomib, pomalidomide|DRUG: Belantamab mafodotin, dexamethasone, ixazomib, pomalidomide|DRUG: Selinexor, dexamethasone, ixazomib, pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Fluconazole vs Voriconazole to Treat Fungal Infections for Blood and Marrow Transplants (BMT CTN 0101)
Status: COMPLETED
Conditions: Lymphoma|Infection|Leukemia
Interventions: DRUG: Fluconazole|DRUG: Voriconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Chemotherapy Prior to Surgery With or Without Zometa for Women With Locally Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Zometa|DRUG: Epirubicin|DRUG: Docetaxel|DRUG: Trastuzumab|RADIATION: External beam radiation|PROCEDURE: Modified radical mastectomy or breast conserving surgery with axillary lymph node dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Irbesartan/Hydrochlorothiazide and Irbesartan in the Treatment of Mild to Moderate Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Irbesartan/hydrochlorothiazide|DRUG: Irbesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atezolizumab and Cabozantinib for the Treatment of Adolescents and Young Adults With Recurrent or Metastatic Osteosarcoma, TACOS Study
Status: SUSPENDED
Conditions: Locally Advanced Osteosarcoma|Metastatic Osteosarcoma|Recurrent Osteosarcoma|Refractory Osteosarcoma|Unresectable Osteosarcoma
Interventions: BIOLOGICAL: Atezolizumab|DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CLAGE Sequential With Flu-Bu Conditioning for Refractory Acute Leukemia
Status: COMPLETED
Conditions: Refractory Hematologic Cancer|Allogeneic Stem Cell Transplantation
Interventions: DRUG: CLAGE-FluBu
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Drowsiness, Cognition, Fall Risk After Metaxalone 640 mg and Metaxalone 800 mg
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: Metaxalone m640 mg oral tablet|DRUG: Metaxalone 800 mg oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Gluma Desensitizer in Post-treatment Sensitivity in Posterior Composite
Status: RECRUITING
Conditions: Sensitivity, Tooth
Interventions: OTHER: GLUMA (Kulzer GmbH, Germany) desensitizing agent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Omega-3 Fatty Acid Supplementation on Skeletal Muscle Membrane Composition and Cellular Metabolism
Status: UNKNOWN
Conditions: Skeletal Muscle Energy Metabolism
Interventions: DIETARY_SUPPLEMENT: Omega-3 Complete|DIETARY_SUPPLEMENT: Placebo Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase I/II Comparison of Efficacy and Safety of BIBF 1120 and Sorafenib in Patients With Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Sorafenib|DRUG: BIBF 1120
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT