pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluation of Esthetic Root Coverage Using Platelet-Rich Fibrin Versus Subepithelial Connective Tissue Graft With Vestibular Incision Subperiosteal Tunnel Access in Multiple Gingival Recessions
Status: UNKNOWN
Conditions: Gingival Recession
Interventions: PROCEDURE: VISTA using PRF|PROCEDURE: VISTA using SCTG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Procedural Outcomes in Endobronchial Ultrasound - Transbronchial Needle Aspiration (EBUS-TBNA) With and Without Rapid On-Site Evaluation (ROSE)
Status: TERMINATED
Conditions: ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION|Benign and Malignant Mediastinal and Hilar Lymph Nodes Known or Suspected Malignancy
Interventions: PROCEDURE: ROSE|DEVICE: 22 gauge Vizishot needles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Enhanced Access to HIV Care for Drug Users in San Juan, Puerto Rico
Status: COMPLETED
Conditions: HIV|AIDS|Substance Abuse
Interventions: BEHAVIORAL: Enhanced HIV Care Access and Retention Intervention|BEHAVIORAL: HIV Testing Campaign|BEHAVIORAL: Treatment Re-engagement Campaign|BEHAVIORAL: Patient Navigator Linkage to Care and Substance Abuse Treatment Team|BEHAVIORAL: Mobile Care Clinic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Integrating Traditional Tuberculosis Care With Modern Health Care on Case Detection
Status: COMPLETED
Conditions: Tuberculosis|Tuberculosis, Pulmonary|Tuberculosis Infection
Interventions: OTHER: Training for traditional and modern care providers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Multi-Center Project: Building Electronic Tools To Enhance and Reinforce CArdiovascular REcommendations - Heart Failure
Status: NOT_YET_RECRUITING
Conditions: Heart Failure
Interventions: OTHER: EHR-Emedded Alert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Placebo-Controlled, Double-Blinded, Randomized Trial of Remicade in Korean Patients With Rheumatoid Arthritis Despite Methotrexate (Study P04280)(COMPLETED)
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: OTHER: Placebo|DRUG: MTX|BIOLOGICAL: Infliximab|DRUG: MTX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of Betalactam ML Prediction Models - TDMAide
Status: NOT_YET_RECRUITING
Conditions: Infections
Interventions: DEVICE: Prediction of plasma concentration of piperacillin-tazobactam or meropenem|DIAGNOSTIC_TEST: Determination of plasma concentration of piperacillin-tazobactam or meropenem|OTHER: Daily short questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Messenger RNA (mRNA)-Based, Personalized Cancer Vaccine Against Neoantigens Expressed by the Autologous Cancer
Status: TERMINATED
Conditions: Melanoma|Colon Cancer|Gastrointestinal Cancer|Genitourinary Cancer|Hepatocellular Cancer
Interventions: BIOLOGICAL: National Cancer Institute (NCI)-4650, a messenger ribonucleic acid (mRNA)-based, Personalized Cancer Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CGRP Induced Migraine Attacks in Patients With High and Low Genetic Load
Status: COMPLETED
Conditions: Migraine Without Aura
Interventions: DRUG: CGRP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate Next Day Effects of TS-142 on Driving Performance in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: TS-142|DRUG: Zopiclone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous vs Intermittent Ketorolac for Pain Control in Peds CV Surgery
Status: RECRUITING
Conditions: Congenital Heart Disease in Children
Interventions: DRUG: Continuous ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intravital Microscopy (IVM) in Patients With Peritoneal Carcinomatosis (PC)
Status: COMPLETED
Conditions: Peritoneal Carcinomatosis
Interventions: DEVICE: Human Intravital Microscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Muscle Composition and Function for Swallowing in Head/Neck Cancer Patients
Status: COMPLETED
Conditions: Head & Neck Cancer
Interventions: BEHAVIORAL: focused attention sessions|BEHAVIORAL: Valchuff|BEHAVIORAL: Pharyngocise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CRC Detection Reliable Assessment With Blood
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer|Adenomas Colon|Colon Cancer|Rectal Cancer|Colon Neoplasm|Colon Lesion|Colon Disease|Colon Polyp|Polyps|Adenoma|Rectal Diseases|Rectal Polyp|Gastrointestinal Neoplasms|Intestinal Neoplasms|Colonic Diseases, Functional|Intestinal Disease
Interventions: DIAGNOSTIC_TEST: Next-Gen CRC Screening Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A 1-year Comparison of Generic Tacrolimus (Tacni) and Prograf in Renal Transplant Patients - a Retrospective Matched Pair Analysis, GenTac
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: Generic tacrolimus|DRUG: Prograf
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Breath Analysis and Arterial Stiffness in Patients With Respiratory Diseases
Status: ENROLLING_BY_INVITATION
Conditions: Chronic Respiratory Diseases|Cystic Fibrosis|Lymphangioleiomyomatosis|Hypersensitivity Pneumonitis|Interstitial Lung Diseases|COPD|Bronchial Asthma
Interventions: DIAGNOSTIC_TEST: Breath test using the Compact PTR-TOF-MS|DIAGNOSTIC_TEST: Portable cardiac monitor "CardioQvark"|DIAGNOSTIC_TEST: Assessment of arterial stiffness using the VaSera VS-1500N
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Retrospective Validation Study To Identify Chart-Based Clinical Diagnosis Of Wild-Type Transthyretin Amyloid Cardiomyopathy (Attrwt-CM) And Non-Amyloid Heart Failure Among Patients With Heart Failure (HF).
Status: COMPLETED
Conditions: ATTR-CM
Interventions: OTHER: Machine learning algorithm
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Analysis of Cutaneous Nerve Biopsies in Gastrointestinal Motility Disorders
Status: WITHDRAWN
Conditions: Small Fiber Neuropathy|Gastrointestinal Dysmotility
Interventions: PROCEDURE: Skin biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Trial of Rivaroxaban Versus Warfarin in Dissolving Left Atrial Appendage Thrombus in Patients With Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation|Left Atrial Appendage Thrombosis|Rivaroxaban
Interventions: DRUG: Rivaroxaban|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pyrotinib Maleate Combined With Vinorelbine in the Treatment of HER2-positive Advanced Breast Cancer
Status: COMPLETED
Conditions: HER2-positive Advanced Breast Cancer
Interventions: DRUG: Pyrotinib Maleate|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Androgenetic Alopecia in Males With Theradome™ LH80 PRO
Status: UNKNOWN
Conditions: Androgenetic Alopecia
Interventions: DEVICE: LH80 PRO|DEVICE: Sham Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Autoarterial Remodeling of Bifurcation of the Common Carotid Artery
Status: COMPLETED
Conditions: Stenosis, Internal Carotid Artery
Interventions: PROCEDURE: Operation carotid endarterectomy with plastic of xenopericardial patch|PROCEDURE: New method of operation сarotid endarterectomy with autoarterial remodeling of bifurcation CCA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Additional Xiaflex® Treatment in Patients With Peyronie's Disease Recurrence, Worsening, or Incomplete Response
Status: UNKNOWN
Conditions: Peyronie's Disease
Interventions: DRUG: Xiaflex® 0.58 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Blood Glucose Regulation and Safety of PPB-R-203-02 Based Noodle Versus Commercially Available Wet Noodle in Patients With Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Commercially Available Wet Noodle|DIETARY_SUPPLEMENT: PPB-R-203-02 Noodle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Role of Apathy in the Effectiveness of Weight Loss Interventions
Status: COMPLETED
Conditions: Obesity|Apathy
Interventions: BEHAVIORAL: MOVE|BEHAVIORAL: medical crisis councelling|BEHAVIORAL: MOVE|DRUG: methyphenidate|BEHAVIORAL: MOVE|DRUG: methyphenidate|BEHAVIORAL: medical crisis councelling|BEHAVIORAL: MOVE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Of Efficacy Of Tazarotene 0.045% Vs Halobetasol Propionate 0.01% Lotion For Treatment of Scalp Psoriasis
Status: COMPLETED
Conditions: Scalp Psoriasis
Interventions: DRUG: Tazarotene 0.045% Topical Application Lotion [ARAZLO]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exatecan Mesylate in Treating Patients With Ewing's Sarcoma, Primitive Neuroectodermal Tumor, or Desmoplastic Small Round Cell Tumor
Status: COMPLETED
Conditions: Sarcoma
Interventions: DRUG: exatecan mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Technology Assisted Care Transition Intervention for Veterans With CHF or COPD
Status: COMPLETED
Conditions: CHF|COPD
Interventions: BEHAVIORAL: Technology-assisted care transition intervention|BEHAVIORAL: Active attention control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Intravascular Irradiation of Blood in Children With Sleep Bruxism
Status: UNKNOWN
Conditions: Sleep Bruxism|Sleep Bruxism, Childhood
Interventions: RADIATION: Intravascular Irradiation of Blood (ILIB)|RADIATION: Placebo Intravascular Irradiation of Blood (ILIB)|PROCEDURE: Orofacial Myofunctional Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PEmbrolizumab Combined With Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck
Status: TERMINATED
Conditions: Squamous Cell Carcinoma of the Head and Neck|Squamous Cell Carcinoma
Interventions: DRUG: Pembrolizumab|RADIATION: Radiotherapy|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: AZD9742 Single and Multiple Ascending Dose Study in Healthy Male and Female Japanese Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD9742|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography Assessment of Ketamine Binding of the Serotonin Transporter
Status: UNKNOWN
Conditions: Depression|Ketamine
Interventions: DRUG: (S)-ketamine (Main study)|DRUG: (S)-ketamine (Pilot II)|DRUG: (R,S)-ketamine (Pilot II)|DRUG: Placebo|OTHER: PILOT Study II: PET1|OTHER: PILOT Study II: PET2|OTHER: Main Study: PET1|OTHER: Main Study: PET2|OTHER: PILOT Study I: PET1|OTHER: PILOT Study I: PET2|DRUG: (R,S)-ketamine (Pilot I)|DRUG: (R,S)-ketamine (Pilot III)|OTHER: PILOT Study III: PET1|OTHER: PILOT Study III: PET2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CEUS vs. AMRI for HCC Detection in Patients With Indeterminate Liver Nodules
Status: RECRUITING
Conditions: HCC|Hepatocellular Carcinoma
Interventions: DIAGNOSTIC_TEST: CEUS vs aMRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: ADCT-602 in Treating Patients With Recurrent or Refractory B-cell Acute Lymphoblastic Leukemia
Status: RECRUITING
Conditions: Blasts 5 Percent or More of Bone Marrow Nucleated Cells|CD22 Positive|Philadelphia Chromosome Positive|Recurrent B Acute Lymphoblastic Leukemia|Refractory B Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: ADCT-602
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Delayed Versus Immediate Use Of Zoledronic Acid For Postmenopausal Patients With Early Breast Cancer Who Are Using Adjuvant Letrozole
Status: UNKNOWN
Conditions: Use of Zoledronic Acid in Breast Cancer
Interventions: DRUG: Zoledronic Acid 4 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Low-dose Radiotherapy Combined With Sintilimab and Temozolomide in Recurrent Glioblastoma
Status: RECRUITING
Conditions: Recurrent Glioblastoma
Interventions: DRUG: Sintilimab|RADIATION: Low-dose Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GENOSS Coronary Stent Clinical Trial
Status: RECRUITING
Conditions: Ischemic Heart Disease
Interventions: DEVICE: Implanatation of Genoss DES sirolimus-eluting coronary system|DEVICE: Implanatation of Xience DES everolimus-eluting coronary system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HDM201 in Combination With MBG453 or Venetoclax in Patients With Acute Myeloid Leukemia (AML) or High-risk Myelodysplastic Syndrome (MDS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia (AML)|High-risk Myelodysplastic Syndrome (MDS)
Interventions: DRUG: HDM201|BIOLOGICAL: MBG453|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First-in-Human Study of Single and Multiple Doses of anle138b in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: anle138b|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of Rapid Tests for the Serological Diagnosis of HIV in 9 to 24 Months Old Children
Status: UNKNOWN
Conditions: Human Immunodeficiency Virus Transmission|Human Immunodeficiency Virus|Diagnoses, Syndromes, and Conditions
Interventions: BEHAVIORAL: This was an observational study of medical devices (rapid tests) used for the HIV diagnosis in children up to 2 years
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Oral IRAK-4 Inhibitor CA-4948 in Combination With Pembrolizumab Following Stereotactic Radiosurgery in Patients With Melanoma Brain Metastases
Status: RECRUITING
Conditions: Melanoma Metastatic in the Brain
Interventions: DRUG: CA-4948|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility, Adoption and Efficacy of A Virtual Reality Smoking Cessation Program for Patients Undergoing Lung Cancer Screening
Status: NOT_YET_RECRUITING
Conditions: Tobacco Use Cessation
Interventions: DEVICE: MindCotine Virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prospective Trial for Clinical Validation of "QOCA Disposable BLE Thermometer "
Status: COMPLETED
Conditions: Fever
Interventions: DEVICE: Q-temp-w1|DEVICE: Omron thermometer(MC-171W)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Effectiveness of Lopinavir/Ritonavir in Individuals Who Have Failed Prior HIV Therapy
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Emtricitabine/Tenofovir disoproxil fumarate|DRUG: Lopinavir/Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of WT1 Peptides to Induce Anti-Leukemia Immune Responses Following Transplantation
Status: TERMINATED
Conditions: Acute Myelogenous Leukemia (AML)|Chronic Myelogenous Leukemia (CML)|Acute Lymphoblastic Leukemia (ALL)|Myelodysplastic Syndrome (MDS)|B Cell Malignancies
Interventions: BIOLOGICAL: WT1 derived peptides
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and/or Metastasectomy in Treating Patients With Metastatic Colorectal Adenocarcinoma With Lung Metastases
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Adenocarcinoma|Colorectal Carcinoma Metastatic in the Lung|Stage IV Colorectal Cancer AJCC v8|Stage IVA Colorectal Cancer AJCC v8|Stage IVB Colorectal Cancer AJCC v8|Stage IVC Colorectal Cancer AJCC v8
Interventions: DRUG: Chemotherapy|PROCEDURE: Metastasectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of the Diagnostic Efficacy of a EUS Guided FNB Needle (AQUIRE®)
Status: UNKNOWN
Conditions: Tumors of the Pancreas|Submucosal Tumor of Gastrointestinal Tract (Disorder)|Lymph Node Disease
Interventions: DEVICE: Endoultrasound guided FNB
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Surgical Site Infection After Skin Closure by Prolene or Staples in Bilateral Knee Arthroplasty Patients
Status: UNKNOWN
Conditions: Total Knee Replacement
Interventions: PROCEDURE: Polypropylene (PROLENE) sutures|PROCEDURE: Staple Sutures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dose Escalation Study of UCART19 in Adult Patients With Relapsed / Refractory B-cell Acute Lymphoblastic Leukaemia
Status: COMPLETED
Conditions: B-cell Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: UCART19
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spinal Cord Stimulation to Shorten Ventilator Dependence in ARDS Patients
Status: RECRUITING
Conditions: Respiratory Distress Syndrome
Interventions: DEVICE: Transcutaneous Biopac Electrical Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Hydralazine on Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: DRUG: Hydralazine hydrochloride 25mg tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CAR-T Cells in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: UNKNOWN
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: DRUG: BCMA CAR-T|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Activated Charcoal on the Absorption of LY2216684 in Healthy Subjects
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: LY2216684|DRUG: Activated Charcoal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Glucosamine/Chondroitin Sulfate to Patients Treatment With Osteoarthrosis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: Glucosamine sulphate and chondroitin sulphate association|DRUG: Cosamin DS® (Nutramax)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Emotional Evaluation and Reconstructed Breast Satisfaction
Status: UNKNOWN
Conditions: Malignant Neoplasm of the Breast
Interventions: DIAGNOSTIC_TEST: First Questionnaire application|DIAGNOSTIC_TEST: Second Questionnaire application
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of RAD001 in Participants With Mantle Cell Lymphoma Who Are Refractory or Intolerant to Velcade® Therapy
Status: COMPLETED
Conditions: Lymphoma, Mantle- Cell
Interventions: DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antibiotic Prophylaxis in Clean Surgery. Impact on Surgical Site Infection
Status: COMPLETED
Conditions: Surgical Site Infection
Interventions: DRUG: Cefazolin|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of the 4.0mm Sirolimus-Eluting Stent in the Treatment of Patients With Coronary Artery Lesions
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: 4.0 CYPHER Sirolimus-Eluting Coronary Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NEOadjuvant Trial in Adenocarcinoma of the oEsophagus and oesophagoGastric Junction International Study (Neo-AEGIS)
Status: COMPLETED
Conditions: Adenocarcinoma of the Oesophagus|Adenocarcinoma of the Oesophago-gastric Junction|Oesophageal Tumours|Junctional Tumours|Oesophageal Cancer
Interventions: DRUG: Epirubicin|DRUG: Cisplatin / Oxaliplatin|DRUG: 5 Flourouracil/ Capecitabine|RADIATION: (41.4 Gy/23 fractions)|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Docetaxel|DRUG: Oxaliplatin|DRUG: Leucovorin|DRUG: 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MMF Versus CTX in the Induction Treatment of ANCA Associated Vasculitis
Status: COMPLETED
Conditions: Vasculitis|Anti-Neutrophil Cytoplasmic Antibody
Interventions: DRUG: mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gradual Withdrawal of Low-dose Glucocorticoid in Clinically Quiescent Systemic Lupus Erythematosus.
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus, SLE
Interventions: BEHAVIORAL: Glucocorticoid withdrawal group|BEHAVIORAL: Glucocorticoid maintenance group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Monovalent Recombinant COVID19 Vaccine
Status: COMPLETED
Conditions: Coronavirus Infection|COVID
Interventions: BIOLOGICAL: COVID19 vaccine|BIOLOGICAL: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Pattern Respiratory PNF Associated Aerobic Training on Lung Volumes and 6MWT Test in Parkinson Individuals
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: OTHER: PNF|DEVICE: treadmill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration
Status: RECRUITING
Conditions: Periodontitis|Periodontal Diseases|Periodontal Pocket
Interventions: PROCEDURE: Non-incised papillae surgical approach (NIPSA)|PROCEDURE: marginal approach by palatal incision|PROCEDURE: Minimally invasive surgical technique (MIST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Novel Therapies for CKD Comorbid Depression
Status: RECRUITING
Conditions: Chronic Kidney Diseases|Major Depressive Disorder
Interventions: DRUG: Bupropion|BEHAVIORAL: Behavioral activation therapy|DRUG: Placebo|OTHER: Clinical Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telemedicine-Based Collaborative Care to Reduce Rural Disparities
Status: COMPLETED
Conditions: Depression
Interventions: OTHER: Telemedicine-Based Collaborative Care|OTHER: Practice Based Collaborative Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Aiding COPD and CHF Ultrasound-guided Management Through ENhanced Point Of Care UltraSound
Status: RECRUITING
Conditions: COPD|CHF|Pneumonia
Interventions: DEVICE: Lung point of care ultrasound|OTHER: PRESUNA software
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Acupuncture for Postoperative Nausea, Vomiting and Pain in Children: The Implication of Parental Attitudes
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting|Postoperative Pain
Interventions: DEVICE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Pain ReliefofBupivacaineWith Dexmedetomidine and Bupivacaine Alone in TransversusAbdominisPlane Block For Postoperative Anelgesia in Patients Undergoing Abdominal Surgeries
Status: UNKNOWN
Conditions: Pain Relief in Post Operative Patient
Interventions: DRUG: dexmeditomidine and bupivacaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness Meditation and Bariatric Surgery
Status: WITHDRAWN
Conditions: Opioid Use|Bariatric Surgery Candidate|Pain, Postoperative
Interventions: BEHAVIORAL: Daily text message|BEHAVIORAL: Mindfulness intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of a Low FODMAP Diet in the Absence of Lactose Malabsorption in Moderate to Severe ROME IV IBS.
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome
Interventions: OTHER: FODMAP diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Trial of Prednisolone in Combination With SPI-62 or Placebo in Subjects With Polymyalgia Rheumatica (PMR)
Status: RECRUITING
Conditions: Polymyalgia Rheumatica
Interventions: DRUG: SPI-62|DRUG: SPI-62 matched placebo|DRUG: Prednisolone 10mg|DRUG: Additional prednisolone|DRUG: Additional prednisolone matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Comparation of Lateral Sagittal Infraclavicular and Costoclavicular Block
Status: UNKNOWN
Conditions: Upper Extremity Problem
Interventions: PROCEDURE: costoclavicular brachial plexus block|PROCEDURE: lateral sagittal infraclavicular block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Long-term Outcome After Gestational Diabetes and Diabetes in Pregnancy
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes, Gestational|Pregnancy Diabetic
Interventions: OTHER: Basic data collection (online survey or written form)|OTHER: Physical examination|BEHAVIORAL: Psychometric examination|DIAGNOSTIC_TEST: Recording of the adrenergic stress reaction (saliva test)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Functional Outcomes Comparison in Patients Using Knee Brace Post ACL Reconstruction With Autograft Bone Quadricep Tendon
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament Injuries|Arthroscopy|Braces
Interventions: DEVICE: Knee Brace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Interaction of Lovastatin and Paclitaxel For Patients With Refractory or Relapsed Ovarian Cancer
Status: TERMINATED
Conditions: Ovarian Cancer
Interventions: DRUG: Paclitaxel|DRUG: Lovastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between Hormonal and Hysteroscopic Management of Cesarean Scar Defect
Status: COMPLETED
Conditions: Cesarean Scar Defect
Interventions: PROCEDURE: hysteroscopic surgery by resection and endocoagulation|PROCEDURE: hysteroscopic surgery by endocoagulation only|DRUG: hormonal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Explanatory Clinical Trial of a Novel Parent Intervention for Childhood Anxiety (SPACE)
Status: COMPLETED
Conditions: Anxiety Disorders|Anxiety, Separation|Phobic Disorders
Interventions: BEHAVIORAL: Parent-Based Treatment of Child and Adolescent Anxiety Disorders|BEHAVIORAL: CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Periodontal Intrabony Defects Using Autologous Platelet Rich Fibrin vs Titanium Platelet Rich Fibrin
Status: COMPLETED
Conditions: Periodontitis
Interventions: PROCEDURE: Open flap debridement (OFD)|PROCEDURE: OFD with Platelet rich fibrin (PRF)|PROCEDURE: OFD with Titanium Platelet rich fibrin (TPRF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Indoor Temperature and Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: OTHER: 16|OTHER: indoor temperature of 20 degrees celcius|OTHER: indoor temperature of 24 degrees celcius
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Postprandial Lipemia and Glycemia Following a High-Fat Meal
Status: COMPLETED
Conditions: Hypercholesterolemia|Postprandial Hyperglycemia|Lipid Disorder
Interventions: DIETARY_SUPPLEMENT: Mushroom Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Two Chemoprophylaxis Approaches After Phacoemulsification Surgery
Status: COMPLETED
Conditions: Endophthalmitis Postoperative
Interventions: DRUG: Moxifloxacin hydrochloride 0.5% eye drops|DRUG: Dexamethasone 0.1% eye drops|DRUG: Intracameral Moxifloxacin 0.1%|DRUG: Subconjunctival Triamcinolone acetonide 4 mg /0.4 ml
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Uncovering and Overcoming the Barriers of Colorectal Cancer Screening Amongst Spouses of Patients With Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: BEHAVIORAL: Current practice|BEHAVIORAL: Targeted intervention programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: The Clinical Effect of Pregabalin on Neuropathic Pain in Central Sensitized Patients After Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Osteoarthritis
Interventions: DRUG: Duloxetine 30mg|DRUG: Pregabalin 150mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab With Intratumoral Injection of Clostridium Novyi-NT
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Neoplasm of Breast|Malignant Neoplasms of Digestive Organs|Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System|Malignant Neoplasms of Female Genital Organs|Malignant Neoplasms of Ill-defined Secondary and Unspecified Sites|Malignant Neoplasms of Independent (Primary) Multiple Sites|Malignant Neoplasms of Lip Oral Cavity and Pharynx|Malignant Neoplasms of Male Genital Organs|Malignant Neoplasms of Mesothelial and Soft Tissue|Malignant Neoplasms of Respiratory and Intrathoracic Organs|Malignant Neoplasms of Thyroid and Other Endocrine Glands|Malignant Neoplasms of Urinary Tract
Interventions: DRUG: Pembrolizumab|BIOLOGICAL: Clostridium Novyi-NT|DRUG: Doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sympathetic Activation in Obesity
Status: COMPLETED
Conditions: Obesity|Healthy
Interventions: DIAGNOSTIC_TEST: PET Scan|DIETARY_SUPPLEMENT: Mixed Meal Test|DIAGNOSTIC_TEST: Muscle sympathetic nerve activity (MSNA)|DIAGNOSTIC_TEST: Oral Glucose Tolerance Test|OTHER: Body Composition, Percent Body Fat & Percent Body Water (Tanita scale)|DIAGNOSTIC_TEST: CT Scan|OTHER: Body Composition, Percent Body Fat & Percent Body Water (DXA Scan)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase II Study of the Effect of a Low Calorie Diet on Patients Undergoing Liver Resection
Status: COMPLETED
Conditions: Nonalcoholic Fatty Liver Disease|Hepatic Steatosis|Steatohepatitis
Interventions: DIETARY_SUPPLEMENT: Optifast 800
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of IV Edotecarin Vs Temozolomide or Carmustine (BCNU) or Lomustine (CCNU) in Patients With Glioblastoma Multiforme
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: Edotecarin|DRUG: Temozolomide|DRUG: Carmustine (BCNU)|DRUG: Lomustine (CCNU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Vardenafil in the Treatment of Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Vardenafil|DRUG: Placebo|DRUG: Vardenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Replacement Volume of Haemodiafiltration and AST-120 on Toxins, Oxidative Stress and MicroInflammation
Status: COMPLETED
Conditions: Loss of Solute Clearance
Interventions: DRUG: Kremezin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transillumination Device for Peripheral Intravenous Placement in Patients With Sickle Cell Disease (PERFID)
Status: COMPLETED
Conditions: Sickle Cell Crisis
Interventions: DEVICE: Accuvein V400 device|OTHER: Routine procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Long-term Efficacy of Imatinib With Hepatic Resection or Other Local Treatment for GIST Liver Metastases
Status: COMPLETED
Conditions: GIST, Malignant|Liver Metastases
Interventions: DRUG: imatinib (IM)|PROCEDURE: hepatic resection (HR)|PROCEDURE: radiofrequency ablation (RFA)|PROCEDURE: transarterial chemoembolization (TACE)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Echogenic Versus Non-echogenic Needles for Venous Access
Status: COMPLETED
Conditions: Anesthesia|Vascular Access Complication
Interventions: DEVICE: echogenic needles for intravenous access
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate MVC-COV1901 Vaccine Against COVID-19 in Adult
Status: COMPLETED
Conditions: Covid19 Vaccine
Interventions: BIOLOGICAL: MVC-COV1901(S protein with adjuvant)|BIOLOGICAL: MVC-COV1901(Saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Descriptive Pilot Study of the Effects of a Standardized Neuromodulation Program on Cortical Brain Function in Chronic Low Back Pain Patients
Status: RECRUITING
Conditions: Low Back Pain|Chronic Low Back Pain
Interventions: OTHER: Neurofeedback treatment|OTHER: functional magnetic resonance imaging (fMRI) scans
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Percutaneous Tibial Nerve Stimulation for the Treatment of Fecal Incontinence
Status: COMPLETED
Conditions: Fecal Incontinence
Interventions: PROCEDURE: active stimulation|PROCEDURE: sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Keto-Brain:Investigating the Use of Ketogenic Diets in Brain Metastases
Status: RECRUITING
Conditions: Brain Metastases, Adult
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Neurocognitive Assessment|OTHER: Questionnaire Administration|DEVICE: Fitbit|DIETARY_SUPPLEMENT: Dietary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Natalizumab De-escalation With Interferon Beta-1b
Status: COMPLETED
Conditions: Relapsing-remitting Multiple Sclerosis
Interventions: DRUG: interferon beta-1b|DRUG: Natalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-pharmacological Interventions on Cognitive Functions in Older People With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment|TTM|Physical Activity|Cognitive Rehabilitation
Interventions: BEHAVIORAL: Exercise|BEHAVIORAL: Cognitive training|BEHAVIORAL: New life-style
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Dapagliflozin on Microvascular Function in Women With Symptoms of Coronary Artery Disease
Status: RECRUITING
Conditions: Myocardial Ischemia
Interventions: DRUG: Dapagliflozin 10mg Tab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study for Efficacy of Side-by-side Compared to Stent-in-stent Technique in the Endoscopic Management of Malignant Hilar Biliary Obstruction
Status: UNKNOWN
Conditions: Cholangiocarcinoma|Gallbladder Cancer|Pancreatic Cancer|HCC|AOV Cancer
Interventions: PROCEDURE: side by side|PROCEDURE: stent in stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Helicobacter Pylori Eradication Study
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Lansoprazole 30mg|DRUG: Amoxicillin 1.0g Tab|DRUG: Clarithromycin 500mg|DRUG: Metronidazole 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pevonedistat With Azacitidine Versus Azacitidine Alone in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: WITHDRAWN
Conditions: Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|DRUG: Pevonedistat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polysomnography Study of MK-6096 in Participants With Primary Insomnia (MK-6096-011)
Status: COMPLETED
Conditions: Primary Insomnia
Interventions: DRUG: MK-6096|DRUG: Dose-matched Placebo to MK-6096
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab Ipilimumab in Patients With hyperMutated Cancers Detected in Blood (NIMBLe)
Status: TERMINATED
Conditions: Advanced Solid Tumors
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Physiologic Insulin Administration on Cognition
Status: ENROLLING_BY_INVITATION
Conditions: Alzheimer Disease
Interventions: OTHER: Blood draws|OTHER: Hyperinsulinemic Euglycemic Clamp Technique Insulin Sensitivity test|OTHER: Resting Metabolic Rate (RMR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Hepatic Impairment on Lazertinib (JNJ-73841937)
Status: COMPLETED
Conditions: Hepatic Impairment|Healthy
Interventions: DRUG: Lazertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: GP_Posit Intervention for Mothers of Preterm Infants for Maternal Sensitivity : Randomized Pilot Trial
Status: COMPLETED
Conditions: Preterm Infant|Mothers|Parent-Child Relations|Child Development|Interaction, Mother-Infant
Interventions: OTHER: GP_Posit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Nuevo Amanecer II: Translating a Stress Management Program for Latinas
Status: COMPLETED
Conditions: Breast Neoplasms|Psychology, Social
Interventions: BEHAVIORAL: Nuevo Amancer-II Stress Management Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Meal Replacement on the Time to Reach the Blood Glucose Target in Patients With Type 2 Diabetes Mellitus
Status: UNKNOWN
Conditions: Diabetes|Blood Sugar; High
Interventions: DIETARY_SUPPLEMENT: Meal Replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Topical Versus Intravenous Tranexamic Acid in Controlling Blood Loss
Status: RECRUITING
Conditions: To Calculate Total Blood Loss Immediately Postoperative
Interventions: DRUG: Tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Persistence of Hepatitis B Antibodies, Immunogenicity and Safety of Engerix™-B Kinder Challenge Dose, in Adolescents Vaccinated With Four Doses of Infanrix™ Hexa During Infancy
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Engerix-B Kinder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety of Faricimab in Patients With Choroidal Neovascularization Secondary to Pathologic Myopia
Status: RECRUITING
Conditions: Choroidal Neovascularization Secondary to Pathologic Myopia
Interventions: DRUG: Faricimab|DRUG: Ranibizumab|PROCEDURE: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Flocked Swabs for the Identification of Group A Streptococcal Pharyngitis
Status: COMPLETED
Conditions: Streptococcal Infection|Pharyngitis
Interventions: DEVICE: Flocked swab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC