pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety of Olaparib (MK-7339) With or Without Bevacizumab Compared to Bevacizumab With a Fluoropyrimidine in Unresectable or Metastatic Colorectal Cancer (CRC) (MK-7339-003/LYNK-003)
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Olaparib|DRUG: 5-FU|DRUG: Bevacizumab|DRUG: Capecitabine|DRUG: Leucovorin/ levoleucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optical Coherence Tomography (OCT) Based Screening of Esophagus and Gastroesophageal Junction
Status: COMPLETED
Conditions: Barrett's Esophagus
Interventions: DEVICE: Optical Frequency Domain Imaging (OFDI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of mRNA-1975 and mRNA-1982 Against Lyme Disease in Participants 18 Through 70 Years of Age
Status: ACTIVE_NOT_RECRUITING
Conditions: Lyme Disease
Interventions: BIOLOGICAL: mRNA-1975|BIOLOGICAL: mRNA-1982|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Prophylaxis of Tuberculosis According to TSPOT Results After Kidney Transplantation
Status: UNKNOWN
Conditions: Kidney Transplant Infection|Tuberculosis|Isoniazid Toxicity
Interventions: DRUG: Isoniazid|OTHER: without any additional anti-tuberculosis treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: MySafeRx & MedicaSafe Open-Label Buprenorphine Induction and Lapse Evaluation (MyMOBILE)
Status: COMPLETED
Conditions: Opioid Use Disorder
Interventions: OTHER: MySafeRx
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose EScalation Induction of EvERolimus
Status: COMPLETED
Conditions: Breast Cancer|Hormone Receptor Positive Tumor
Interventions: DRUG: 3 weeks Dose Induction of Everolimus|DRUG: 3 weeks Conventional Everolimus Dosing|DRUG: Open Label Phase with conventional 10mg Everolimus Dosing week 4-24|DRUG: Standard Care after 24 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenetically-guided Escitalopram Treatment for Pediatric Anxiety: Aiming to Improve Safety and Efficacy (PrEcISE)
Status: RECRUITING
Conditions: Anxiety
Interventions: DRUG: Escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Efficacy of TTP273 for 12 Weeks in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: TTP273|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Wound Healing in Primary TKA
Status: ENROLLING_BY_INVITATION
Conditions: Total Knee Replacement|Wound Complication
Interventions: PROCEDURE: Skin closure using skin adhesive|PROCEDURE: Skin closure without skin adhesive
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation Planning Consult Phase II Trial
Status: COMPLETED
Conditions: Head and Neck Neoplasms
Interventions: BEHAVIORAL: Rehabilitation Planning Consult (RPC)|OTHER: Wait list control (WLC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Double-Blinded Randomized Controlled Study Investigating the Efficacy of Exparel (Liposomal Bupivacaine) for Postoperative Pain Relief in Mandibular Third Molar Extractions
Status: ACTIVE_NOT_RECRUITING
Conditions: Post Operative Pain
Interventions: DRUG: Liposomal bupivacaine|DRUG: 0.5% bupivacaine with 1:100,000 epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Does Supplementing Vitamin D Deficiency Affect Fusion Healing Rates in Elective Foot and Ankle Surgery?
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DRUG: Vitamin D2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Everolimus, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: concurrent RAD001 10 mg/day|DRUG: concurrent temozolomide|RADIATION: Radiation therapy|DRUG: concurrent RAD001 2.5 mg/day|DRUG: concurrent RAD001 5 mg/day|DRUG: post-radiation RAD001 10 mg/day|DRUG: post-radiation temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endovenous Lidocaine and Serum Cytokines Concentration
Status: COMPLETED
Conditions: Cholelithiasis
Interventions: DRUG: Lidocaine|DRUG: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation of a Waitlist Intervention and Clinical Care Pathway for Families Awaiting at Eating Disorders Program
Status: COMPLETED
Conditions: Eating Disorders
Interventions: BEHAVIORAL: Parental guided self-help version of FBT-pre-recorded videos and readings from the book
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diaphragmatic Doming vs Breathing Exercises on Ventilatory Function & Core Endurance in Chronic Neck Pain
Status: COMPLETED
Conditions: Neck Pain
Interventions: OTHER: Diaphragmatic Breathing Exercise|OTHER: Pursed Lip Breathing Exercise|OTHER: Doming of the diaphragm|OTHER: Conventional exercise program for chronic neck pain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Boanmycin Hydrochloride With Docetaxel for Patients With Lung Squamous Cell Cancer as Chemotherapy
Status: UNKNOWN
Conditions: Squamous Cell Lung Cancer
Interventions: DRUG: Boanmycin|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prediction of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage Using Dynamic 18F-FDG PET/CT
Status: COMPLETED
Conditions: Aneurysmal Subarachnoid Haemorrhage
Interventions: OTHER: Early dynamic 18F-FDG PET/CT assessment of cerebral glucose uptake
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Message 2: The Effect of Message Content and Clinical Outcome on Patient's Perception of Physician Compassion
Status: COMPLETED
Conditions: Advanced Cancers
Interventions: BEHAVIORAL: Questionnaires|BEHAVIORAL: Video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Oral Alpha-Cyclodextrin for Decreasing Serum Cholesterol
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: OTHER: Placebo|DRUG: Alpha cyclodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on Adoptive Treatment of MDR-TB With Allogeneic γδT Cells
Status: UNKNOWN
Conditions: Multi-drug Resistant Tuberculosis
Interventions: BIOLOGICAL: The adoptive treatment of allogeneic γδT cells|OTHER: Control|DRUG: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin C as an Adjunct in Periodontal Treatment in Type 2 Diabetes Mellitus Patients
Status: UNKNOWN
Conditions: Diabetes Mellitus Type 2 With Hyperglycemia|Periodontitis
Interventions: DRUG: Vitamin C 500 MG Oral Capsule|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Behavioral Therapy for Sleep Problems
Status: TERMINATED
Conditions: Insomnia
Interventions: BEHAVIORAL: Digital cognitive-behavioral therapy for insomnia (dCBTI)|BEHAVIORAL: Sleep hygiene education (SHE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Screening for Genetic Forms of Diabetes in Convention of Care for Children and Adolescents With Diabetes (GENEPEDIAB)
Status: COMPLETED
Conditions: Diabetes Mellitus|MODY
Interventions: GENETIC: Mody test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Fish Oral Immunotherapy in Hong Kong Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Fish Allergy|Food Allergy in Children
Interventions: OTHER: Fish oral immunotherapy (codfish)|OTHER: Placebo oral immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glucobrassicin-Brussel Sprout Effect on D10 Phe Metabolism
Status: COMPLETED
Conditions: Smoking
Interventions: OTHER: Brussel Sprouts|DRUG: Deuterated Phenanthrene
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Drug-eluting Stents vs. Drug-coated Balloon for Preventing Recurrent In-stent Restenosis
Status: TERMINATED
Conditions: Coronary Restenosis
Interventions: DEVICE: Everolimus-eluting balloon expandable stent|DEVICE: paclitaxel eluting balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Swedish Evaluation of Left Ventricular Assist Device as Permanent Treatment in End-stage Heart Failure
Status: RECRUITING
Conditions: End-stage Heart Failure
Interventions: DEVICE: HM III|OTHER: OMM, optimal medical management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Locally Advanced Rectal Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Rectum|Mucinous Adenocarcinoma of the Rectum|Signet Ring Adenocarcinoma of the Rectum|Stage IIA Rectal Cancer|Stage IIB Rectal Cancer|Stage IIC Rectal Cancer|Stage IIIA Rectal Cancer|Stage IIIB Rectal Cancer|Stage IIIC Rectal Cancer
Interventions: DRUG: fluorouracil|DRUG: oxaliplatin|RADIATION: radiation therapy|DRUG: leucovorin calcium|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rectus Sheath Block for Analgesia After Gynecological Laparotomy
Status: NOT_YET_RECRUITING
Conditions: Gynecologic Surgical Procedures
Interventions: PROCEDURE: Rectus sheath block|PROCEDURE: Thoracic Epidural Analgesia|DRUG: Liposomal bupivacaine|DRUG: Bupivacaine Hydrochloride|DRUG: Bupivacaine-Hydromorphone Cassette
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immunonutrition and Quality of Life of Cancer Patients Undergoing Oncological Treatment
Status: COMPLETED
Conditions: Gastrointestinal Cancer
Interventions: DIETARY_SUPPLEMENT: Nutritional supplements containing arginine, n-3 and nucleotides|DIETARY_SUPPLEMENT: Isocaloric control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Elastic Tape on Pulmonary Rehabilitation of Patients With Chronic Obstructive Pulmonary Disease
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Experimental: Elastic tape (ET)|OTHER: Sham Comparator: Sham (SH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Frailty Assessment and Implementation of Interventions in Women Over 70 With Epithelial Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer|Chemotherapy|Quality of Life|Tolerance|Aged
Interventions: OTHER: Functional Geriatric Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Improving Functional Outcomes of Veterans With PTSD and Tobacco Dependence
Status: COMPLETED
Conditions: Tobacco|Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy for PTSD and Tobacco Use|BEHAVIORAL: Freedom From Smoking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study Assessing Safety and Efficacy of Bedaquiline Plus PA-824 Plus Linezolid in Subjects With Drug Resistant Pulmonary Tuberculosis
Status: COMPLETED
Conditions: Pulmonary Tuberculosis
Interventions: DRUG: Bedaquiline|DRUG: PA-824|DRUG: Linezolid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Meditation Accelerated Brain Stimulation for Depression
Status: RECRUITING
Conditions: Depression
Interventions: DEVICE: Medi1TMS|DEVICE: Medi2TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Loxenatide Plus LNG-IUS in Endometrial Atypical Hyperplasia
Status: RECRUITING
Conditions: Atypical Endometrial Hyperplasia|Obesity|Fertility Issues
Interventions: DEVICE: levonorgestrel-releasing intrauterine system|DRUG: Polyethylene Glycol Loxenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prazosin Treatment for Disruptive Agitation in Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Prazosin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Addressing Behaviour and Treatment Effectiveness Project (A.B.A.T.E. Project)
Status: COMPLETED
Conditions: Disruptive Behavior Disorder
Interventions: BEHAVIORAL: Coping Power|BEHAVIORAL: Individualized Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: H5 Vaccine Alone or With Aluminum Hydroxide in Elderly Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Aluminum hydroxide|BIOLOGICAL: Inactivated Influenza A/H5N1 Vaccine (sanofi pasteur)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Rovalpituzumab Tesirine (SC16LD6.5) in the Frontline Treatment of Patients With Extensive Stage Small Cell Lung Cancer
Status: TERMINATED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Rovalpituzumab Tesirine|DRUG: Cisplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intraoperative Infusion of Dexmedetomidine Versus Low Dose Ketamine
Status: RECRUITING
Conditions: Nasal Polyps|Nasal Septum, Irregular|Functional Endoscopic Sinus Surgery
Interventions: DRUG: Ketamine Hydrochloride|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sacubitril/Valsartan for CKD5 Stage Dialysis Patients
Status: COMPLETED
Conditions: CKD5 Stage Dialysis|Heart Failure
Interventions: DRUG: Sacubitril/Valsartan|DRUG: Irbesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Urinary NGF as A Biomarker for Acute Bacterial Cystitis
Status: COMPLETED
Conditions: Urinary Tract Infection
Interventions: DRUG: Baktar 800mg h.s.|DRUG: Celecoxib 200mg QD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Battlefield Acupuncture and Its Use In Multimodal Perioperative Anesthesia Care
Status: COMPLETED
Conditions: Acupuncture, Ear
Interventions: DEVICE: Auricular acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Accell Evo3 Demineralized Bone Matrix (DBM) in Instrumented Posterolateral Lumbar Spine Fusion
Status: COMPLETED
Conditions: Stenosis|Spondylosis|Degenerative Changes
Interventions: DEVICE: Demineralized Bone Matrix|DEVICE: rh-BMP2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Preventive Effect of Establishing an Integrated Working Group of Doctors and Nurses in Operating Room
Status: NOT_YET_RECRUITING
Conditions: Orthopedic Disorder|Incision Infection
Interventions: OTHER: an integrated working group nursing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: The Efficacy and Safety of Fang yi Qing Feng Shi Granules in Subjects With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Fang yi qing feng shi granule|DRUG: placebo|DRUG: Methotrexate|DRUG: Acetaminophen tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Trial of Conbercept Intravitreal Injection for Neovascular AMD (PANDA-1)
Status: TERMINATED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: BIOLOGICAL: 0.5 mg Conbercept Intravitreal Injection|BIOLOGICAL: 1.0 mg Conbercept Intravitreal Injection|BIOLOGICAL: 2.0 mg Aflibercept Intravitreal Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Possible Effects of Propylthiouracil, Riociguat and Perphenazine on Circulation of Healthy Volunteers
Status: COMPLETED
Conditions: Drug Drug Interaction|Safety Issues
Interventions: DRUG: Propylthiouracil, Riociguat, Perphenazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Different Doses of ZED1227 vs. Placebo in NAFLD
Status: COMPLETED
Conditions: NAFLD|Liver Fibrosis
Interventions: DRUG: ZED1227|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics of Oral Formulations of MMV390048 Administered Fasted to Healthy Volunteers
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: MMV390048 formulation A|DRUG: MMV390048 formulation B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Development of a Community-based HCV Treatment Completion Intervention Among HCV Positive Homeless Adults
Status: COMPLETED
Conditions: Hepatitis C Virus (HCV) Infection
Interventions: BEHAVIORAL: Community health worker (CHW)/ registered nurse (RN) [CHW/RN]|BEHAVIORAL: Clinic-based Standard of Care (cbSOC) Program (control group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First in Human Study of AUR 103 Calcium to Evaluate Safety, Pharmacokinetics and Pharmacodynamics
Status: RECRUITING
Conditions: Solid Tumor, Adult|Acute Myeloid Leukemia|Myelodysplastic Syndromes|Non Hodgkin Lymphoma
Interventions: DRUG: AUR103
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liraglutide as Add on Therapy on Metformin in Women With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: PCOS|Obesity
Interventions: DRUG: Metformin|DRUG: Glucophage tablets and Victoza
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerance of Cannabidiol in Patients With Severe Pruritus: a Multicenter, Double-blind, Randomized, Placebo-controlled Study
Status: NOT_YET_RECRUITING
Conditions: Pruritus
Interventions: DRUG: Cannabis oil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Alcohol Drinkers' Exposure to Preventive Therapy for TB (ADEPTT)
Status: COMPLETED
Conditions: Tuberculosis|HIV/AIDS|Alcohol Abuse
Interventions: DRUG: Isoniazid 300 Mg ORAL TABLET|DRUG: Pyridoxine 25 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of the GORE® EXCLUDER® Iliac Branch Endoprosthesis
Status: COMPLETED
Conditions: Common Iliac Artery Aneurysms|Aorto-iliac Aneurysms
Interventions: DEVICE: GORE® EXCLUDER® Iliac Branch Endoprosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fenretinide in Treating Patients With Biochemically Recurrent Hormone-Naïve Prostate Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Prostate|Recurrent Prostate Cancer
Interventions: DRUG: fenretinide|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clearance Rate of Peritoneal Fluid After Full Conditioning Pneumoperitoneum
Status: COMPLETED
Conditions: Laparoscopic Hysterectomy
Interventions: PROCEDURE: Carbon dioxide|PROCEDURE: full conditioning|DRUG: Adept|DRUG: Ringer Lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Pilot Study of Citicoline add-on Therapy in Patients With Bipolar Disorder or Major Depressive Disorder and Amphetamine Abuse or Dependence
Status: COMPLETED
Conditions: Amphetamine Abuse|Amphetamine Dependence|Bipolar Disorder|Major Depressive Disorder
Interventions: DRUG: Citicoline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Fermented Ginseng (GINST) on Sperm Motility
Status: UNKNOWN
Conditions: Asthenozoospermia
Interventions: DIETARY_SUPPLEMENT: fermented ginseng (GINST)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Two Days of Bedrest on Insulin Resistance in Type 2 Diabetics
Status: COMPLETED
Conditions: Type 2 Diabetes|Insulin Resistance
Interventions: OTHER: Study 2 (48 hours of complete bed rest)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Manual Therapy Program to Reduce the Evolution Time of Axillary Web Syndrome
Status: RECRUITING
Conditions: Breast Cancer|Mastectomy; Lymphedema|Thrombi|Thrombosis|Shoulder Syndrome|Movement Disorders
Interventions: OTHER: Manual Therapy, Physiotherapy, Kinesiology, Scar Massage|OTHER: Kinesiotherapy, Physiotherapy, Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Learn When Platelets Return to Normal After One Loading Dose of Anti-platelet Drugs in Patients With Symptoms of Acute Coronary Syndromes
Status: TERMINATED
Conditions: Acute Coronary Syndromes
Interventions: DRUG: clopidogrel|DRUG: prasugrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Workflow and Satisfaction Study Evaluating the Implementation of a New "Smart" Ambulatory Infusion System
Status: COMPLETED
Conditions: Home Healthcare Organizations Utilizing Ambulatory Infusion Pumps|Patients Requiring Infusion With an Ambulatory Infusion Pump
Interventions: DEVICE: CADD®-Solis VIP Pump|DEVICE: CADD™ Solis Medication Safety Software Administrator
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase III Expansion Trial for Determining the Safety and Efficacy of Recombinant Human Coagulation Factor VIII-Fc Fusion Protein for Injection in Adolescent and Adult Patients With Hemophilia A
Status: COMPLETED
Conditions: Hemophilia A
Interventions: DRUG: Recombinant Human Coagulation Factor VIII-Fc Fusion Protein for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-market Clinical Follow-up Study for a CE Marked Wound Care Product (FibDex®)
Status: NOT_YET_RECRUITING
Conditions: Skin Transplantation
Interventions: DEVICE: FibDex®|DEVICE: Suprathel|DEVICE: Aquacel Foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Assess the Effect of Zolpidem, Silenor & Placebo on Arousability, Ataxia/Balance & Cognition in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Silenor 6 mg|DRUG: zolpidem 10 mg|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Double-blind, Randomized, Placebo-controlled Phase 3 Study of Etanercept in the Treatment of Psoriatic Arthritis and Psoriasis
Status: COMPLETED
Conditions: Psoriatic Arthritis|Psoriasis
Interventions: OTHER: Placebo|DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Different Modalities in Reducing Airborne Particulate Concentrations During AGP for Health Volunteers
Status: COMPLETED
Conditions: Transmission, Patient-Professional
Interventions: DEVICE: Filter|DEVICE: Scavenger face tent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Yangxue Qingnao Pills in the Treatment of Mild to Moderate Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease|Yangxue Qingnao Pills|Randomized
Interventions: DRUG: Yangxue Qingnao pills|DRUG: Yangxue Qingnao pills|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Spironolactone in Cameroonian Diabetic Patients With Resistant Hypertension
Status: COMPLETED
Conditions: Hypertension, Resistant to Conventional Therapy|Diabetes Mellitus
Interventions: DRUG: Low dose spironolactone|OTHER: Routine intensification of antihypertensive treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Zirconium Zr 89 Crefmirlimab Berdoxam PET/CT in Subjects With Advanced or Metastatic Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma|Merkel Cell Carcinoma, Unspecified|Renal Cell Carcinoma|Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: zirconium Zr 89 crefmirlimab berdoxam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Avenues Study: Dual Use Cessation
Status: NOT_YET_RECRUITING
Conditions: Smoking Cessation|Electronic Cigarette Use
Interventions: DRUG: Varenicline|DRUG: Nicotine patch|BEHAVIORAL: Dual Focused Cessation Counseling|BEHAVIORAL: Smoking Focused Cessation Counseling|OTHER: Counseling Intensity: 1 Session|OTHER: Counseling Intensity: 4 Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of TLH and LAVH With Over Than 500g
Status: COMPLETED
Conditions: Hysterectomy, Benign Uterine Diseases
Interventions: PROCEDURE: TLH vs LAVH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fudan University Shanghai Cancer Center Breast Cancer Precision Platform Series Study- Neoadjuvant Therapy
Status: RECRUITING
Conditions: Breast Neoplasm|Breast Cancer|Breast Tumors|Triple-Negative Breast Cancer (TNBC)|HER2-positive Breast Cancer|HER2-negative Breast Cancer|Hormone Receptor Positive Tumor|Hormone Receptor Negative Tumor|Early-stage Breast Cancer|Locally Advanced Breast Cancer
Interventions: DRUG: Dalpiciclib|DRUG: Pyrotinib|DRUG: SHR-A1811|DRUG: SHR-1316|DRUG: Camrelizumab|DRUG: SHR-A1921|DRUG: Pertuzumab|DRUG: Trastuzumab|DRUG: Goserelin|DRUG: Letrozole|DRUG: Nab paclitaxel|DRUG: Carboplatin|DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: Fluzoparib|DRUG: Apatinib|DRUG: Famitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diet Treatment Glucose Transporter Type 1 Deficiency (G1D)
Status: ACTIVE_NOT_RECRUITING
Conditions: GLUT1DS1|Epilepsy|Glut1 Deficiency Syndrome 1, Autosomal Recessive|Glucose Metabolism Disorders|Glucose Transport Defect|Glucose Transporter Type 1 Deficiency Syndrome|Glucose Transporter Protein Type 1 Deficiency Syndrome
Interventions: DRUG: Triheptanoin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Video-Based Rehabilitation Program on Pain, Functionality and Quality of Life in the Treatment of Rotator Cuff Tears
Status: COMPLETED
Conditions: Rotator Cuff Tear|Pain, Shoulder
Interventions: OTHER: Video-Based Rehabilitation Program|OTHER: Physiotherapist-Supervised Rehabilitation Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparing State Payer Strategies to Prevent Unsafe Opioid Prescribing
Status: COMPLETED
Conditions: Opioid Use|Opioid-Related Disorders
Interventions: OTHER: Prospective prior authorization (PA) with hard stops in Washington|OTHER: Retrospective review (RR) with prescriber notification in Ohio
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multi-PAP: Improving Prescription in Primary Care Patients With Multimorbidity and Polypharmacy
Status: COMPLETED
Conditions: Multimorbidity|Polypharmacy|Other Diagnoses, Comorbidities, and Complications
Interventions: OTHER: Multi-PAP|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Transepithelial Corneal Cross-linking Using Iontophoresis
Status: COMPLETED
Conditions: Progressive Keratoconus
Interventions: DEVICE: Cross-linking with iontophoresis|DEVICE: Standard corneal cross-linking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Versus Multi-port Robotic Assisted Sacrocolpopexy for Repair of Vaginal Apex Prolapse
Status: COMPLETED
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: Single-port sacrocolpopexy|PROCEDURE: Multi-port sacrocolpopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of Live Attenuated Mumps Vaccines in Healthy Infants
Status: COMPLETED
Conditions: Mumps
Interventions: BIOLOGICAL: investigational live attenuated mumps vaccine|BIOLOGICAL: control live attenuated mumps vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Development and Validation of an Online Independent Training Program for TOR-BSST© Dysphagia Screeners
Status: COMPLETED
Conditions: Dysphagia|Stroke
Interventions: OTHER: TOR-BSST© eLearning Training|OTHER: Standard TOR-BSST© Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Blood Pressure and OXygenation Targets After OHCA
Status: COMPLETED
Conditions: Out-of-Hospital Cardiac Arrest|Blood Pressure|Hemodynamic Instability
Interventions: OTHER: Low normal MAP|OTHER: High normal MAP|OTHER: Low normal PaO2.|OTHER: High normal PaO2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Clinical Trial of a 13-valent Pneumococcal Conjugate Vaccine in Healthy Infants
Status: COMPLETED
Conditions: Pneumonia
Interventions: BIOLOGICAL: 13-valent pneumococcal conjugate vaccine|BIOLOGICAL: Prevnar 13
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: 89Zr-AMG211 PET Imaging Study
Status: COMPLETED
Conditions: Advanced Gastrointestinal Cancer
Interventions: DRUG: 89Zr-AMG211|DEVICE: 89-ZrAMG211 PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measurement of Total Retinal Blood Flow During Flicker Stimulation in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: FDOCT|DEVICE: LDV|DEVICE: DVA|DEVICE: LSFG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Iron and Retinopathy of Prematurity (ROP)
Status: RECRUITING
Conditions: Retinopathy of Prematurity
Interventions: BIOLOGICAL: Plasma determination of iron, transferrin and ferritin|OTHER: Fundus Examination by wide field digital imaging camera (PanocamTM camera)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fentanyl With or Without Bupivacaine in Reducing Pain in Patients Undergoing Video-Assisted Chest Surgery
Status: COMPLETED
Conditions: Pain|Perioperative/Postoperative Complications
Interventions: DRUG: Fentanyl citrate|DRUG: Bupivacaine hydrocloride|PROCEDURE: videothoracoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determine the Safety/Efficacy of Ticagrelor for Maintaining Patency of Arterio-Venous Fistulae Created for Hemodialysis
Status: COMPLETED
Conditions: End Stage Renal Disease|Vascular Access Patency
Interventions: DRUG: ticagrelor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Observational Basket Trial to Collect Tissue to Train and Validate a Live Tumor Diagnostic Platform
Status: RECRUITING
Conditions: Colorectal Cancer|Head and Neck Squamous Cell Carcinoma|Non Small Cell Lung Cancer|Cutaneous Melanoma|Endometrial Cancer|Urothelial Carcinoma|Clear Cell Renal Cell Carcinoma
Interventions: PROCEDURE: Core Needle or Forceps Biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Herbal Alternatives for Menopause Symptoms (HALT Study)
Status: UNKNOWN
Conditions: Vasomotor Symptoms Associated With Menopause
Interventions: DRUG: Black cohosh|DRUG: Multibotanical preparation|DRUG: Multibotanical preparation + dietary soy counseling|DRUG: Conjugated equine estrogen +/- medroxyprogesterone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Deucravacitinib Versus Placebo in Participants With Moderate-to-severe Scalp Psoriasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Psoriasis
Interventions: DRUG: Deucravacitinib|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate Symbicort Turbuhaler Used 'as Needed' in Adults and Adolescents With Asthma.
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: budesonide/formoterol 'as needed' + budesonide placebo bid|DRUG: terbutaline 'as needed' + placebo budesonide bid|DRUG: budesonide bid + terbutaline 'as needed'
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect Aflibercept on Ocular Perfusion
Status: COMPLETED
Conditions: Macular Degeneration|Anti Vascular Endothelial Growth Factor
Interventions: DRUG: Aflibercept Injection [Eylea]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sternal Wound Infection in Patients Undergone Sternal Fixation Using Locking Compression Plates
Status: UNKNOWN
Conditions: Sternal Fracture|Sternal Wound Infection|Surgical Site Infection
Interventions: OTHER: Locking Compression Plates|OTHER: Sternal Wires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Bupropion|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BEST SFA Pilot Study - Best Endovascular STrategy for Complex Lesions of the Superficial Femoral Artery
Status: ACTIVE_NOT_RECRUITING
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: Stent-avoiding|DEVICE: Stent-based
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Clinical Performance Study of the ARTUS® Artificial Urinary Sphincter (AUS)
Status: NOT_YET_RECRUITING
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: Artificial Urinary Sphincter implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Immunoassay Measurements of Pancreatic Stone Protein Performed on abioSCOPE® Device With the PSP Assay on ICU Patients at Risk of Sepsis as an Aid in Identifying Sepsis
Status: COMPLETED
Conditions: Sepsis
Interventions: DEVICE: Blood sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cannabidiol as an add-on Treatment During Inpatient Alcohol Cessation : CBD-OH
Status: RECRUITING
Conditions: Severe Alcohol Use Disorder (DSM 5)
Interventions: DRUG: Placebo|DRUG: Half dose CBD|DRUG: Full dose CBD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Absorption and Metabolism of Olive Leaf Extract and Its Effect on Vascular Reactivity and Cytokine Concentrations
Status: COMPLETED
Conditions: Absorption and Metabolism|Effect on Vascular Function|Effect on Cytokine Concentrations
Interventions: DIETARY_SUPPLEMENT: Olive leaf extract capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Rifaximin for Patients With Chronic Intestinal Pseudo-obstruction: a Phase 2 Trial
Status: UNKNOWN
Conditions: Chronic Intestinal Pseudo-obstruction
Interventions: DRUG: Rifaximin oral tablet|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Coronary Flow During Rapid Heart Rates
Status: RECRUITING
Conditions: Ventricular Tachycardia|Coronary Artery Disease|Heart Failure|Coronary Microvascular Dysfunction|Coronary Microvascular Disease
Interventions: DIAGNOSTIC_TEST: Pressure and flow measurement during simulated VT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Mesna on Homocysteine in Kidney Failure
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DRUG: Mesna|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemoradiation and Panitumumab for Esophageal Cancer
Status: COMPLETED
Conditions: Squamous Cell Carcinoma|Adenocarcinoma|Esophageal Cancer|Gastro-esophageal Junction Cancer
Interventions: DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: panitumumab|RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GI Permeability Change in Response to Aquamin®
Status: ACTIVE_NOT_RECRUITING
Conditions: Ulcerative Colitis|Healthy|Irritable Bowel Syndrome With Diarrhea
Interventions: DRUG: Aquamin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SUNCIST: A Study of Calmangafodipir in Healthy Japanese and Caucasian Subjects
Status: COMPLETED
Conditions: Chemotherapy Induced Peripheral Neuropathy (CIPN)
Interventions: DRUG: Calmangafodipir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Corneal Collagen Cross-linking for Progressive Keratoconus
Status: COMPLETED
Conditions: Progressive Keratoconus
Interventions: DRUG: riboflavin ophthalmic solution|DEVICE: UVA Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Taxol Epirubicin Cyclophosphamide Herceptin Neoadjuvant (TECHNO)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Epirubicin / Cyclophosphamide in combination with Paclitaxel/Trastuzumab, followed by postoperative Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Lumen Study: Comparing Devices for Patients With Symptomatic Femoro-popliteal Chronic Total Occlusion (CTO)
Status: TERMINATED
Conditions: Symptomatic Femoro-popliteal Chronic Total Occlusion
Interventions: DEVICE: TruePath CTO Device|DEVICE: CROSSER CTO Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Three Common Bile Duct Closure Techniques
Status: COMPLETED
Conditions: Common Bile Duct Closure
Interventions: PROCEDURE: T tube drainage|PROCEDURE: Primary closure|PROCEDURE: Antegrade stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Risk Factors, Body Composition, Fitness Levels And Quality Of Life In Overweight And Obese 8-17 Year Olds
Status: COMPLETED
Conditions: Childhood Obesity|Type 2 Diabetes|Hypercholesterolemia|Hypertension
Interventions: OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects With Degenerative Disc Disease
Status: TERMINATED
Conditions: Degenerative Disc Disease
Interventions: DRUG: SM04690
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flow Cytometric Analysis of Peripheral Blood Neutrophil Myeloperoxidase Expression and Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Myelodysplastic Syndromes|Chronic Myelomonocytic Leukemia
Interventions: DIAGNOSTIC_TEST: Flow cytometry analysis of neutrophil myeloperoxidase expression
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p