pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Single-Dose Relative Bioavailability Study of SST-6006, a Topical Sildenafil Cream Versus Oral Sildenafil in Healthy Male Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 5% Sildenafil Cream (SST-6006)|DRUG: Oral Sildenafil 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interactive, Health Literacy Promoting Text Messages and HPV Vaccine Completion In Minority Adolescents
Status: COMPLETED
Conditions: Human Papillomavirus
Interventions: BEHAVIORAL: Conventional text message reminder|BEHAVIORAL: Enhanced text message reminders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Dexmedetomidine Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia
Status: UNKNOWN
Conditions: Spinal Diseases|Local Anesthesia
Interventions: DRUG: Dexmedetomidine|DRUG: Lidocaine|DRUG: Low-dose Dexmedetomidine|DRUG: Moderate-dose Dexmedetomidine|DRUG: High-dose Dexmedetomidine|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Compare The Effect of Pendulum Exercises With the Kaltenborn Mobilization Among the Patients of Adhesive Capsulitis
Status: RECRUITING
Conditions: Adhesive Capsulitis
Interventions: DIAGNOSTIC_TEST: Pendulum Exercises|DIAGNOSTIC_TEST: Kaltenborn Mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy Study of Oral Seliciclib to Treat Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: seliciclib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ASTX727 and Dasatinib for the Treatment of Newly Diagnosed Philadelphia Chromosome or BCR-ABL Positive Chronic Myeloid Leukemia in Chronic Phase
Status: RECRUITING
Conditions: Chronic Phase Chronic Myelogenous Leukemia|Philadelphia Chromosome Positive|BCR-ABL1 Positive Chronic Myelogenous Leukemia|BCR-ABL1 Positive
Interventions: DRUG: Dasatinib|DRUG: Decitabine and Cedazuridine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tofacitinib for Hospitalized Acute Severe Ulcerative Colitis Management
Status: ACTIVE_NOT_RECRUITING
Conditions: Ulcerative Colitis Acute
Interventions: DRUG: Tofacitinib 10 MG [Xeljanz]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Unmet Needs of Cancer Survivors in Ausl IRCCS Reggio Emilia
Status: RECRUITING
Conditions: Cancer|Breast Cancer|Prostate Cancer|Thyroid Cancer|Colorectal Cancer|Lymphoma|Multiple Myeloma|Neoplasms
Interventions: OTHER: Focus Groups or Interviews
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Test How Well Patients With Advanced Solid Tumors Respond to Treatment With the Elimusertib in Combination With Pembrolizumab, to Find the Optimal Dose for Patients, How the Drug is Tolerated and the Way the Body Absorbs, Distributes and Discharges the Drug
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: Elimusertib (BAY1895344)|DRUG: Pembrolizumab (Keytruda®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Morphine Versus Ketorolac in Renal Colic
Status: UNKNOWN
Conditions: Renal Colic
Interventions: DRUG: Ketorolac|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Characterize the Pharmacokinetics of a Single Dose of SC Abatacept 125 mg Using the BD Autoinjector or the Prefilled Syringe
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Abatacept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Safety, and Tolerability of Depot Buprenorphine at Three Different Molecular Weights in Treatment-Seeking Subjects With Opioid Use Disorder
Status: COMPLETED
Conditions: Opioid Use Disorder
Interventions: DRUG: RBP-6000|DRUG: SUBOXONE Sublingual Film
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Systemic Corticosteroids in the Perioperative Management of Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
Status: WITHDRAWN
Conditions: Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
Interventions: DRUG: Prednisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders
Status: NOT_YET_RECRUITING
Conditions: Smoking Cessation|Harm Reduction
Interventions: DRUG: Nicoderm|DRUG: Nicorette 4Mg Chewing Gum|DRUG: Nicorette Lozenge Product|OTHER: NJOY e-cigarette|OTHER: on!
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Implementation and Evaluation for the Family-oriented Care CHIMPS-NET
Status: UNKNOWN
Conditions: Mental Health Issue
Interventions: BEHAVIORAL: Optimal pathways to care|BEHAVIORAL: Education and training program for the professionals|BEHAVIORAL: Systematic screening|OTHER: TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: OPTIFIT-Optimal Fiber Trial for Diabetes Prevention
Status: COMPLETED
Conditions: Diabetes|Nutrition Disorders|Obesity|Overweight|Metabolic Syndrome x|Body Weight|Glucose Metabolism Disorders|Metabolic Diseases
Interventions: DIETARY_SUPPLEMENT: Fiber|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Methotrexate and Statins With Methotrexate Alone in the Treatment of Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Simvastatin 20 mg|DRUG: Methotrexate 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Imatinib (Gleevec) as Treatment for Advanced Thymic Carcinoma
Status: COMPLETED
Conditions: Thymic Carcinoma
Interventions: DRUG: Gleevec (imatinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interferon Gamma-1b Administered Topically for Macular Edema/Intraretinal Schisis Cysts in Rod-Cone Dystrophy (RCD) and Enhanced S-Cone Syndrome (ESCS)
Status: TERMINATED
Conditions: Inherited Ophthalmic Diseases|Inherited Retinal Degeneration
Interventions: DRUG: Interferon gamma-1b
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Morphologic Evolution and Remodeling of Intracranial Atherosclerosis: A Longitudinal Study by 3D-rotational Angiography
Status: RECRUITING
Conditions: Ischemic Stroke|Atheroscleroses, Cerebral
Interventions: DIAGNOSTIC_TEST: 3DRA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pilot Study of Laser Photocoagulation for Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: PROCEDURE: modified-ETDRS photocoagulation|PROCEDURE: Mild Macular Grid photocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brain Function in Premenopausal Women Receiving Tamoxifen With or Without Ovarian Function Suppression for Early-Stage Breast Cancer on Clinical Trial IBCSG 24-02
Status: COMPLETED
Conditions: Breast Cancer|Fatigue|Sleep Disorders
Interventions: DRUG: Tamoxifen|DRUG: triptorelin|DRUG: Exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: The Neoadjuvant Treatment of Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Thoracic Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Camrelizumab+Albumin bound paclitaxel+Cisplatin|DRUG: Camrelizumab+ Paclitaxel+ Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brief mHealth Self-Compassion Intervention on Internalized Weight Bias
Status: COMPLETED
Conditions: Obesity|Stigma, Social
Interventions: BEHAVIORAL: Self-compassion mindfulness practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Study of Romiplostim in Thrombocytopenic Pediatric Patients With Immune Thrombocytopenia (ITP)
Status: COMPLETED
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Romiplostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amyloid Imaging And Safety Study Of Subcutaneous Bapineuzumab In Subjects With Mild to Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Experimental Bapineuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Melatonin as Neuroprotectant in Preterm Infants
Status: COMPLETED
Conditions: Malondialdehyde|Melatonin
Interventions: DIETARY_SUPPLEMENT: melatonin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Maximizing trEatment of Neurological Dysfunction Using INtravenous Guanfacine Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Critical Illness|Delirium|Cognitive Impairment
Interventions: DRUG: Guanfacine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protective Role of Muscle Function for Early Features of Knee Osteoarthritis After Anterior Cruciate Ligament Injury
Status: COMPLETED
Conditions: Knee Osteoarthritis|Anterior Cruciate Ligament Injury|Osteoarthritis, Knee|Muscle Weakness
Interventions: OTHER: Measures of muscle function
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Renal Protective Effects of Renin Angiotensin System (RAS) Inhibitor in Peritoneal Dialysis Patients
Status: COMPLETED
Conditions: Renal Function Disorder
Interventions: DRUG: Benazepril|DRUG: Valsartan|DRUG: Benazepril+Valsartan|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of XL999 in Patients With Acute Myeloid Leukemia (AML)
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|AML
Interventions: DRUG: XL999
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Gabapentin Use In Head And Neck Mucosal Surgery Patients
Status: COMPLETED
Conditions: Head and Neck Cancer|Acute Pain|Postoperative Pain
Interventions: DRUG: Gabapentin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Penpulimab Combined With Chemotherapy for Neoadjuvant and Adjuvant Therapy in Patients With Resectable HNSCC
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Penpulimab injection|DRUG: cisplatin|DRUG: albumin-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Two Methods to Follow Patients With Pancreatic Cysts
Status: RECRUITING
Conditions: Pancreatic Carcinoma
Interventions: PROCEDURE: Computed Tomography|PROCEDURE: Endoscopic Ultrasound|PROCEDURE: Magnetic Resonance Imaging|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TLK286 (Telcyta) in Combination With Carboplatin (Paraplatin) Versus Doxil in Platinum Refractory or Resistant Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Neoplasms
Interventions: DRUG: TLK286 in Combination with Carboplatin|DRUG: Doxorubicin HCl Liposome Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ladarixin With Sotorasib in Advanced NSCLC
Status: RECRUITING
Conditions: Advanced Non-small Cell Lung Cancer With KRAS G12C Mutation
Interventions: DRUG: Sotorasib|DRUG: Ladarixin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing Psychosocial Treatment Planning Methods for Youth Anxiety and Depression
Status: COMPLETED
Conditions: Anxiety Disorders|Depressive Disorder
Interventions: BEHAVIORAL: Modular Approach to Therapy for Children (MATCH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Is Correcting Total Serum Calcium Levels Important After Thyroidectomy
Status: UNKNOWN
Conditions: Hypocalcemia|Thyroid|Parathyroid Dysfunction|Calcium Disorder|Hormone Disturbance|Postoperative Complications
Interventions: DIAGNOSTIC_TEST: Total serum calcium blood test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigation on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NN9924 in Healthy Male Subjects
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2|Healthy
Interventions: DRUG: semaglutide|DRUG: placebo|DRUG: semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of MGCD0103 (MG-0103) in Patients With Refractory Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Lymphocytic Leukemia, Chronic
Interventions: DRUG: MGCD0103
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Infasurf®(Calfactant) Aerosol for Infants With Bronchiolitis-AERO-04
Status: TERMINATED
Conditions: Bronchiolitis
Interventions: COMBINATION_PRODUCT: Aerosolized Infasurf
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of FluMist With and Without Ampligen
Status: TERMINATED
Conditions: Influenza, Human
Interventions: DRUG: Poly I:Poly C12U 50 ug|DRUG: Poly I:Poly C12U 200 ug|DRUG: Poly I:Poly C12U 500 ug|DRUG: Poly I:Poly C12U 1250 ug|DRUG: Placebo|DRUG: FluMist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ibuprofen vs Dipyrone After C-section in Preeclampsia
Status: COMPLETED
Conditions: Preeclampsia
Interventions: DRUG: medication 1|DRUG: medication 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Doses of Budesonide on Markers of Bone Metabolism in Children With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: budesonide|DRUG: D3 vitamin|DRUG: montelukast sodium|DRUG: salbutamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Assessment of the Effectiveness of Ultrasound-guided Acupuncture in the Management of Carpal Tunnel Syndrome
Status: UNKNOWN
Conditions: Carpal Tunnel Syndrome
Interventions: DRUG: SHINCORT|DRUG: XYLOCAINE|DEVICE: sham electroacupuncture|DEVICE: electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Fall-risk Prediction in Older Adults With Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: OTHER: Baseline Participant Assessment|OTHER: Baseline Healthcare Provider Assessment|OTHER: Follow-up Participant Assessment|OTHER: Follow-up Healthcare Provider Assessment|OTHER: End-of-study Participant Assessment|OTHER: End-of-study Healthcare Provider Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pupillary Response to Incremental Tetanic Stimulations Under Propofol-remifentanil TCI
Status: COMPLETED
Conditions: Pain
Interventions: PROCEDURE: general anesthesia for scheduled gynecological surgery|DRUG: Propofol|DRUG: Remifentanil, Ultiva®|PROCEDURE: tetanic stimulations|DEVICE: VideoAlgesiGraph
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: 18F-Fluciclovine PET to Distinguish Tumor Progression From Radiation Necrosis
Status: COMPLETED
Conditions: Secondary Malignant Neoplasm of Brain and Cerebral Meninges
Interventions: DRUG: 18F-fluciclovine|DEVICE: PET/CT of the brain
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of SGB-9768 in Adult Healthy Volunteers
Status: NOT_YET_RECRUITING
Conditions: Healthy Volunteer
Interventions: DRUG: SGB-9768|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating a Heated Lidocaine and Tetracaine Topical Patch in the Treatment of Patients With Patellar Tendinopathy
Status: COMPLETED
Conditions: Patellar Tendinopathy
Interventions: DRUG: Heated Lidocaine and Tetracaine Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Metabolic Surgery on Pancreatic, Renal and Cardiovascular Health in Youth With Type 2 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 2 Diabetes Mellitus|Obesity|Bariatric Surgery Candidate|Nephropathy|Diabetic Kidney Disease|Diabetes Mellitus, Type 2|Diabetes Mellitus|Diabetes Complications|Weight Loss|Diabetic Nephropathies|Adolescent Obesity|Pediatric Obesity
Interventions: DRUG: Aminohippurate Sodium Inj 20%|DRUG: Iohexol Inj 300 mg/mL|PROCEDURE: Vertical Sleeve Gastrectomy|PROCEDURE: Renal Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Assess the Safety and Pharmacokinetics of AKB-6548 in Participants With Chronic Kidney Disease (CKD), Stages 3 and 4
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Vadadustat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Tibial Neuro-stimulation to Improve Voiding Dysfunction in Multiple Sclerosis.
Status: UNKNOWN
Conditions: Multiple Sclerosis|Lower Urinary Tract Symptoms
Interventions: DEVICE: PTNS de verum|DEVICE: PTNS placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Vagus Nerve Stimulator in Patients With Rheumatoid Arthritis (RA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DEVICE: SetPoint Medical Neurostimulation of the Cholinergic Anti-inflammatory Pathway System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Tivantinib With or Without Erlotinib Hydrochloride in Treating Patients With Metastatic or Locally Advanced Kidney Cancer That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Recurrent Renal Cell Carcinoma|Stage III Renal Cell Cancer|Stage IV Renal Cell Cancer|Type 1 Papillary Renal Cell Carcinoma|Type 2 Papillary Renal Cell Carcinoma
Interventions: DRUG: Erlotinib Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Tivantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK And Safety Study Of PF-04171327 In Healthy Japanese And Western Subjects In Fasting And Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-04171327|DRUG: PF-04171327|DRUG: PF-04171327|DRUG: Placebo|DRUG: PF-04171327|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Renal Failure in the Surgical Intense Care Units - NTUH-SICU-ARF (NSARF) Study
Status: UNKNOWN
Conditions: Acute Renal Failure|Sepsis|Postoperative
Interventions: DEVICE: CVVH and SLED|DRUG: Vancomycin|DRUG: Daptomycin|DEVICE: FX60, AV600 (dialyzer)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: HSP90 Inhibitor, AUY922, in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (Post-PV MF), Post-Essential Thrombocythemia Myelofibrosis (Post-ET MF), and Refractory PV/ET
Status: TERMINATED
Conditions: Myeloproliferative Neoplasms
Interventions: DRUG: AUY922
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CMAB807X Pre- and Post-change in Manufacturing Site and Xgeva® in Healthy Volunteers
Status: WITHDRAWN
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: Post-change CMAB807X|BIOLOGICAL: Pre-change CMAB807X|BIOLOGICAL: Xgeva®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of BTK Inhibitor BGB-3111 in Chinese Subjects With Relapsed/Refractory Waldenström's Macroglobulinemia (WM)
Status: COMPLETED
Conditions: Waldenström's Macroglobulinemia (WM)
Interventions: DRUG: Zanubrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Scintigraphy Study to Evaluate the Gastrointestinal Behavior of EDP1815 Oral Dosage Forms
Status: COMPLETED
Conditions: Disintegration|Healthy
Interventions: DRUG: EDP1815 capsule A|DRUG: EDP1815 capsule B|DRUG: EDP1815 tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Preterm Erythropoietin Neuroprotection Trial (PENUT Trial)
Status: COMPLETED
Conditions: Extreme Prematurity
Interventions: DRUG: Epo|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prescribing Asthma Controller Medication According to Gene Status to Improve Quality of Life in Young People With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: GENETIC: Personalised medicine (Salmeterol)|GENETIC: Personalised medicine (Montelukast)|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Dosage of Umbilical Cord-mesenchymal Stem Cells Through Peripheral Vein in Patients With ESLD
Status: RECRUITING
Conditions: End-stage Liver Diseases
Interventions: BIOLOGICAL: umbilical cord-mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare PK/PD Characteristics and Safety Profiles Between AD-212-A and AD-2121
Status: COMPLETED
Conditions: Gastro Esophageal Reflux
Interventions: DRUG: Lansoprazole 15 mg|DRUG: Lansoprazole 15mg/Calcium carbonate 600mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dried Fruit and Postprandial Glycemia Trial
Status: UNKNOWN
Conditions: PreDiabetes|Diabetes Mellitus|Dysglycemia
Interventions: OTHER: White Bread (Control)|OTHER: Dried Fruit - Glycemic Index|OTHER: Catalytic Fructose Dose Effect|OTHER: High GI Displacement Effect
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose:
Clinical trial: An in Vivo Comparison of the Debridement Efficiency of Needle Irrigation Versus Ultrasonic Irrigation
Status: WITHDRAWN
Conditions: Extirpation of the Tooth Pulp
Interventions: DEVICE: Vista Ultrasonic Bleach Bypass System|DEVICE: Needle Irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lidocaine Versus Fentanyl for Hemodynamic Stability
Status: COMPLETED
Conditions: Hypertension|Fentanyl|Lidocaine
Interventions: DRUG: Lidocaine IV|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stop Emergency Room Visits for Hyperglycemia Project - District of Columbia (DC)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Antihyperglycemic medication guideline for management of uncontrolled hyperglycemia presenting to the ED using metformin, sulfonylurea and/or insulin|BEHAVIORAL: Diabetes survival skills self-management education
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Timing of Intrauterine Insemination in Relation to Positive Home Ovulation Prediction Kit
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: Intrauterine Insemination|DRUG: Clomiphene|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Assessment of the Different Etiological and Susceptibility Markers in Patients With Pancreatitis: Investigating IG4, Cytomegalovirus, Coxsackie- Virus, Genetic Polymorphism of Vitamin D Receptor Gene
Status: UNKNOWN
Conditions: Acute Pancreatitis
Interventions: GENETIC: Measurement of VDR genetic polymorphism
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Platelet-Rich Plasma vs Corticosteroid Injection as Treatment for Degenerative Pathology of the Temporomandibular Joint
Status: WITHDRAWN
Conditions: Degenerative Joint Disease
Interventions: DRUG: Group A (corticosteroid injection group)|BIOLOGICAL: Group B (platelet rich plasma injection group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Assess the Relative Bioavailability of TMC207 Following Single-Dose Administrations of Two Pediatric Formulations in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy|Biological Availability
Interventions: DRUG: Treatment A (reference)|DRUG: Treatment B|DRUG: Treatment C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Efficacy and Safety of the Use of Two Eye Gel Products Containing 5% Dexpanthenol in Patients With Moderate to Severe Dry Eye Syndrome
Status: RECRUITING
Conditions: Dry Eye Disease
Interventions: DEVICE: Myrialen Gel|DEVICE: Recugel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Therapeutic Potential of Stigma Maydis (Cornsilk) on Metabolic Syndrome
Status: NOT_YET_RECRUITING
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Corn silk powder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Mupirocin Dressings Versus Island Dressings on Surgical Site Infections in Elective Colorectal Surgery
Status: COMPLETED
Conditions: Surgical Site Infections
Interventions: PROCEDURE: mupirocin ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Adding Liraglutide to High Dose Insulin: Breaking the Cycle
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Obesity
Interventions: DRUG: Liraglutide|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study: Compare the Effectiveness Between Two Pain Medications When Used Prior to Ultherapy™ Treatments
Status: COMPLETED
Conditions: Skin Laxity
Interventions: DRUG: Advil|DRUG: Lortab|DEVICE: Ulthera System Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Respiratory Tele Monitoring COVID 19 (TMR COVID-19)
Status: TERMINATED
Conditions: Covid19
Interventions: DEVICE: Radius PPG Tetherless Pulse Oximetry (Masimo)|DEVICE: usual monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Ocular Electroacupuncture on Trochlear Nerve Palsy
Status: UNKNOWN
Conditions: Trochlear Nerve Palsy
Interventions: OTHER: ocular electroacupuncture|OTHER: ocular acupuncture|OTHER: sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study to Evaluate Safety and Tolerability of Peginesatide for Long-Term Treatment of Anemia in Participants With CKD (EU)
Status: TERMINATED
Conditions: Chronic Renal Failure|Chronic Kidney Disease|Anemia
Interventions: DRUG: peginesatide|DRUG: peginesatide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: E-Visit for COPD and Smoking Cessation
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|Cigarette Smoking|Telemedicine
Interventions: BEHAVIORAL: smoking cessation, early COPD detection, electronic visit|OTHER: Treatment As Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cracking the Egg Potential: Improving Young Child Nutrition in Ecuador
Status: COMPLETED
Conditions: Choline Deficiency|Vitamin B-12 Deficiency|Lipids Deficiency|Amino Acids Deficiency
Interventions: OTHER: Egg supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Whole- Body Vibration Among Egyptian Elderly With Sarcopenia
Status: ACTIVE_NOT_RECRUITING
Conditions: Sarcopenia
Interventions: DEVICE: Whole-body vibration|OTHER: aerobic exercises|OTHER: resistance exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Simultaneous Therapy With Intravitreal Dexamethasone Implant and Bevacizumab for the Treatment of Macular Edema
Status: COMPLETED
Conditions: Macular Edema
Interventions: DRUG: simultaneous treatment with intravitreal injection of bevacizumab 1.25mg and intravitreal implant of dexamethasone 0.7mg.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: IOP and Ocular Biometrics Changes After Phacoemulsification in Glaucoma Patients and Controls
Status: COMPLETED
Conditions: Glaucoma|Cataract
Interventions: PROCEDURE: phacoemulsification and Intraocular lens implantation|DIAGNOSTIC_TEST: Ultrasound Biomicrosopy (UBM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of in Vivo and in Vitro Transcriptomic and Proteomic Signatures in Unhereditary Ichtyosis
Status: COMPLETED
Conditions: Autosomal Recessive Congenital Ichthyosis|Epidermolytic Ichthyosis
Interventions: OTHER: Biological samples|OTHER: Skin biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Two Treatments for Post-Traumatic Stress Disorder
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: DRUG: Sertraline|BEHAVIORAL: Cognitive behavioral therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Handing to Patients a Copy of the Consultation Report on Their Medicine Consumption
Status: COMPLETED
Conditions: Viral Gastro Enteritis|Pharyngitis
Interventions: OTHER: Written medical report and standardized medical advices|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Educational Intervention for Better Nutrition to Preserve Functionality - Design of a Randomised Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: Malnutrition
Interventions: OTHER: Education video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Greater Occipital Nerve Block With Bupivacaine for Acute Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: PROCEDURE: Greater occipital nerve block|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PULSAR - A Prospective Study to Evaluate the Utility of Low Doses of the Statins Atorvastatin and Rosuvastatin.
Status: COMPLETED
Conditions: Hypercholesterolaemia
Interventions: DRUG: Rosuvastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Motor Cortex Versus Sacral Magnetic Stimulation in Multiple Sclerosis Patients With Urinary Tract Dysfunction
Status: COMPLETED
Conditions: Multiple Sclerosis|Lower Urinary Tract Symptoms
Interventions: OTHER: magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3D Sonographic Measurement of Volumetric Flow in Transjugular Intrahepatic Porto-Systemic Shunts
Status: COMPLETED
Conditions: Portal Hypertension|Liver Disease
Interventions: PROCEDURE: Volumetric Flow in TIPS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Preventing Violence Among Veterans in Substance Use Disorder Treatment
Status: COMPLETED
Conditions: Aggression|Substance-Related Disorders
Interventions: BEHAVIORAL: MI-CBT|BEHAVIORAL: MI-CBT+CC|BEHAVIORAL: E-TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Effectiveness of a Nasal Spray to Treat Seasonal Allergies
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Placebo|DRUG: 0.15% azelastine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Sintilimab in Combination With Axitinib in Advanced Renal Cell Cancer
Status: NOT_YET_RECRUITING
Conditions: Renal Cell Carcinoma|Clear Cell Renal Cell Carcinoma
Interventions: DRUG: Sintilimab|DRUG: Axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Low Dosage of Terazosin in Subjects Undergoing Carotid Artery Stenting
Status: UNKNOWN
Conditions: Carotid Artery Stenosis
Interventions: DRUG: Terazosin|PROCEDURE: Carotid artery stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lumbar Puncture Stylet Technique in Children
Status: RECRUITING
Conditions: Traumatic Tap
Interventions: PROCEDURE: Lumbar puncture using the stylet-in technique|PROCEDURE: Lumbar puncture using the stylet-out technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Umbilical Cord Mesenchymal Stem Cells in Duchenne Muscular Dystrophy
Status: UNKNOWN
Conditions: Duchenne Muscular Dystrophy
Interventions: BIOLOGICAL: Umbilical Cord Mesenchymal Stem Cell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Tramadol Versus Oral Celecoxib for Post-perineal Repair Analgesia
Status: UNKNOWN
Conditions: Perineal Pain
Interventions: DRUG: Tramadol Hydrochloride|DRUG: Celecoxib 200mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-Beam Intensity-Modulated Radiation Therapy for Node-Positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: RADIATION: Multi-Beam Intensity-Modulated Radiation Therapy|BEHAVIORAL: BreastQ questionnaire-
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ARX788 for Treating Patients With HER2-low Locally Advanced Unresectable or Metastatic Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: HER2 Low Breast Carcinoma|Triple Negative Breast Cancer|Hormone-receptor-positive Breast Cancer|Hormone Receptor Positive Breast Carcinoma
Interventions: DRUG: ARX788|PROCEDURE: Computed Tomography (CT)|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Apelin on Insulin Sensitivity: Proof of Concept in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Apelin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dysfunctions and Plasticity Mechanisms of Motor System Assessed by Cortico-cortical and Cortico-muscular Coherence Analysis in Amyotrophic Lateral Sclerosis
Status: SUSPENDED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: PROCEDURE: electroencephalograms (EEG)|PROCEDURE: electro-myography (EMG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sodium Oxybate Versus Midazolam for Comfort Sedation
Status: COMPLETED
Conditions: Palliative Care
Interventions: DRUG: Sodium Oxybate injection|DRUG: Midazolam injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Acute Otitis Externa
Status: COMPLETED
Conditions: Acute Otitis Externa
Interventions: DRUG: DF289 plus DF277|DRUG: DF289|DRUG: DF277
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implant Retained CAD-CAM Ceramic Crowns
Status: COMPLETED
Conditions: Prosthesis Survival
Interventions: DEVICE: PFM Crowns on gold coping cast-on|DEVICE: hybrid abutment lithium disilicate crown|DEVICE: hybrid abutment ceramic polymer infiltrated crown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: International Normalised Ratio Evaluation by Generalist Practitioners in Full-time Care Establishments for the Elderly
Status: COMPLETED
Conditions: Aged|Nursing Homes
Interventions: DEVICE: CoagucheckXSR Capillary INR measures
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy Study of ICXP007 With Compression Bandaging for the Treatment of Non-Infected Venous Leg Ulcers
Status: UNKNOWN
Conditions: Leg Ulcer
Interventions: DRUG: ICXP007
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Anti-PD-1 Antibody, Sintilimab, as Second-line Therapy for Biomarker-selected Advanced or Metastatic NSCLC
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrical Vagal Nerve Stimulation in Ulcerative Colitis
Status: TERMINATED
Conditions: Ulcerative Colitis|Vagal Nerve Stimulation|Transcutaneous Vagal Nerve Stimulation
Interventions: DEVICE: Transcutaneous vagal nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of Recombinant Trivalent Poliomyelitis Vaccine (Sf-RVN Cell) in Healthy Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: Recombinant Trivalent Poliomyelitis Vaccine (Sf-RVN Cell) (VLP-Polio)|BIOLOGICAL: Inactivated poliomyelitis vaccine (IPOL)|BIOLOGICAL: VLP-Polio|BIOLOGICAL: IPOL|BIOLOGICAL: VLP-Polio|BIOLOGICAL: IPOL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transversus Abdominis Plane (TAP) Block for Postoperative Analgesia After Laparoscopic Colonic Resection
Status: COMPLETED
Conditions: Colonic Cancer|Rectal Cancer|Colonic Diverticulum|Ulcerative Colitis
Interventions: PROCEDURE: Ultrasound guided Transversus Abdominis Plane (TAP) bock|PROCEDURE: Local anaesthetic infiltration of laparoscopic port sites
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Factor IX Gene Therapy With PF-06838435 in Adult Males With Moderately Severe to Severe Hemophilia B
Status: ACTIVE_NOT_RECRUITING
Conditions: Hemophilia B
Interventions: BIOLOGICAL: PF-06838435/ fidanacogene elaparvovec
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conjunctival Vascularity Changes Usnig OCTA After Trabeculectomy
Status: UNKNOWN
Conditions: OCTA
Interventions: PROCEDURE: Trabectulectomy|DRUG: Mitomycin|DEVICE: Ologen Collagen Implant|DEVICE: Mitomycin-C Kyowa®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Plant-based Nutritional Products on Stem Cells
Status: UNKNOWN
Conditions: Stem Cell Mobilization|Hematopoietic Stem Cell Mobilization|Stem Cell Homing
Interventions: OTHER: Berry extract I|OTHER: Berry Extract II|OTHER: Berry extract blend|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Optimized Management of Nivolumab Based on Response in Patients With Advanced RCC (OMNIVORE Study)
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cancer
Interventions: DRUG: Ipilimumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Protein Diet Supplemented With Ketoanalogs on Reducing Proteinuria and Maintaining Nutritional Status in Type 2 Diabetic Nephropathy
Status: UNKNOWN
Conditions: Type 2 Diabetic Nephropathy
Interventions: DIETARY_SUPPLEMENT: Compound α-Ketoacid Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT