pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of CB-839 in Combination w/ Paclitaxel in Participants of African Ancestry and Non-African Ancestry With Advanced Triple Negative Breast Cancer (TNBC)
Status: COMPLETED
Conditions: Triple Negative Breast Cancer|TNBC - Triple-Negative Breast Cancer
Interventions: DRUG: Paclitaxel|DRUG: CB-839
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The PredictPlusPrevent Study
Status: NOT_YET_RECRUITING
Conditions: Depression|Anxiety Disorders
Interventions: BEHAVIORAL: Predictplusprevent intervention|OTHER: Psychoeducational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Comparative Study of Depth of Anesthesia Monitored by Bispectral Index (BIS) Values
Status: COMPLETED
Conditions: Anesthetics
Interventions: DRUG: propofol|DRUG: thiopental,propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GOREISAN for Heart Failure (GOREISAN-HF) Trial
Status: RECRUITING
Conditions: Heart Failure|Edema|Traditional Japanese Medicine|Kampo Medicine|Clinical Trial
Interventions: DRUG: Goreisan|DRUG: Standard Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Lung Bioavailability of HFA-Seretide Via Current Spacer Devices in Healthy Volunteers
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Seretide 250(8puffs) via Evohaler actuator|DRUG: Seretide 250 (8 puffs)/placebo via Volumatic spacer|DRUG: Seretide 250/placebo 8 puffs via Aerochamber Plus spacer|DRUG: Seretide 250/placebo via Synchro-Breathe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Lumiracoxib in Patients With Primary Knee Osteoarthritis(OA)
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Lumiracoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of a Chronic Retinal Stimulator in Retinitis Pigmentosa
Status: COMPLETED
Conditions: Retinitis Pigmentosa
Interventions: DEVICE: Argus 16 Retinal Stimulation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability of Oral Suspension of Rivaroxaban Compared to Standard Tablet
Status: COMPLETED
Conditions: Biological Availability
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Consumption of Eggs Rich in Lutein and Omega-3 Fatty Acids on the Macular Pigment
Status: COMPLETED
Conditions: Age-related Macular Degeneration
Interventions: OTHER: Nutritional study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of METOprolol in CARDioproteCtioN During an Acute Myocardial InfarCtion. The METOCARD-CNIC Trial.
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: Injectable (i.v.) metoprolol tartrate (up to 15 mg).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Abuse Potential of Rapastinel in Humans
Status: COMPLETED
Conditions: Human Abuse Potential
Interventions: DRUG: Rapastinel|DRUG: Ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Intense Pulsed Light as an Adjunctive to Bromonidine for the Treatment of Rosacea
Status: WITHDRAWN
Conditions: Rosacea
Interventions: DRUG: Bromonide 0.33% gel|DEVICE: Intense Pulsed Light (M22)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Functional Task Training Combined With Therapeutic Ultrasound on Adults With Hip Osteoarthritis
Status: WITHDRAWN
Conditions: Osteoarthritis, Hip
Interventions: OTHER: Functional task-training|DEVICE: Therapeutic Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Men and Women With Different Designs and Semi-individual Total Knee Replacement
Status: NOT_YET_RECRUITING
Conditions: Arthroplasty, Replacement, Knee
Interventions: PROCEDURE: semi-individualized total knee replacement treatment with a gender-specific design|PROCEDURE: Zimmer total knee replacement prostheses (Zimmer, Warsaw, IN, USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Efficacy of Phenylbutyrate (PBA) vs. Benzoate in Urea Cycle Disorders
Status: COMPLETED
Conditions: Urea Cycle Disorders, Inborn
Interventions: DRUG: Sodium Benzoate|DRUG: Sodium Phenylbutyrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Evaluate Effects of Probenecid, Rifampin and Verapamil on Bexagliflozin in Healthy Subjects
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Bexagliflozin|DRUG: Probenecid|DRUG: Rifampin|DRUG: Verapamil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Establishing the Recommended Biological Dose for AE37 Peptide Vaccine in Combination With Pembrolizumab That Will Enhance the Tumor-specific Immune Response and Demonstrate Efficacy in Patients With Advanced Triple-negative Breast Cancer
Status: UNKNOWN
Conditions: Triple-negative Breast Cancer
Interventions: BIOLOGICAL: AE37 Peptide vaccine|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Decision Support to Reduce Catheter Associated Urinary Tract Infections
Status: COMPLETED
Conditions: Health Care Associated Infection|Catheter-associated Urinary Tract Infection
Interventions: OTHER: Clinical decision support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase IIa Trial of a Selective Glucocorticoid Receptor Antagonist in the Treatment of Veterans With Posttraumatic Stress Disorder (PTSD) (Seven Study)
Status: RECRUITING
Conditions: PTSD
Interventions: DRUG: CORT108297|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lymphatic System Stimulation in Heart Failure
Status: RECRUITING
Conditions: Heart Failure
Interventions: BEHAVIORAL: The Optimal Lymph FLow (TOLF)|BEHAVIORAL: Daily Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PD-1 Inhibition in Advanced Myeloproliferative Neoplasms
Status: COMPLETED
Conditions: Chronic Phase Myelofibrosis|Primary Myelofibrosis|Post-essential Thrombocythemia Myelofibrosis|Polycythemia Vera
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microwave Ablation Versus Laparoscopic Hepatectomy for 3-5cm Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Overall Survival|Progression-free Survival|Cost
Interventions: PROCEDURE: Microwave Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acamprosate and Methazolamide for Essential Tremor
Status: WITHDRAWN
Conditions: Essential Tremor
Interventions: DRUG: Acamprosate|DRUG: Placebo|DRUG: Methazolamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of CITI-002 in Adult Patients With Moderate Grade Hemorrhoids
Status: COMPLETED
Conditions: Hemorrhoids
Interventions: DRUG: Monad 1|DRUG: Monad 2|DRUG: Monad 3|DRUG: Combination - CITI-002 (low dose)|DRUG: Combination - CITI-002 (high dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence and Safety Study of Bevacizumab-biosimilar (RPH-001) Compared to Bevacizumab-innovator
Status: WITHDRAWN
Conditions: Healthy
Interventions: BIOLOGICAL: RPH001|BIOLOGICAL: Avastin®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Surgical Repair of Chest on Postural Stability Among Patients With Pectus Excavatum
Status: COMPLETED
Conditions: Pectus Excavatum
Interventions: PROCEDURE: Nuss repair of Pectus Excavatum|DRUG: Epidural anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Study of GT201 in the Treatment of Advanced Gynecological Tumors (Advanced Cervical Cancer)
Status: RECRUITING
Conditions: Adult|Gynecological Tumors
Interventions: BIOLOGICAL: Autologous tumor infiltrating lymphocyte injection（GT201）
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Are Newborns Conscious of the Placebo Effect? Result From an RCT in Osteopathy
Status: COMPLETED
Conditions: Prematurity
Interventions: OTHER: Sham Osteopathic Manipulative Treatment|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Arm Study of Post-transplant Azacitidine and Chidamide for Prevention of Acute Myelogenous Leukemia Relapse
Status: UNKNOWN
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: Azacitidine|DRUG: Chidamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Mesalamine in Diarrhea-predominant Irritable Bowel Syndrome (dIBS)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Mesalamine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin E and N-acetylcysteine for Preventing Contrast-Induced Acute Kidney Injury After Coronary Artery Catheterization
Status: UNKNOWN
Conditions: Coronary Artery Disease|Coronary Artery Angiography|Coronary Catheterization|Contrast-induced Nephropathy|Stable Angina|Acute Coronary Syndrome
Interventions: DRUG: Vitamin E|DRUG: N-acetyl cysteine|DRUG: Placebo oral capsule|DRUG: Placebos|DRUG: Normal Saline Flush, 0.9% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Acupuncture and Insulin Doses in Insulin-treated Type 2 Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: PROCEDURE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Moxifloxacin in Pediatric Subjects With Complicated Intra-abdominal Infection
Status: COMPLETED
Conditions: Intraabdominal Infections
Interventions: DRUG: Moxifloxacin (Avelox, BAY12-8039)|DRUG: Ertapenem|DRUG: Amoxicillin/Clavulanate|DRUG: Moxifloxacin placebo|DRUG: Ertapenem placebo|DRUG: Amoxicillin/Clavulanate placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Of The Taste Of Different Oral Liquid Preparations Of CP-690,550 In Trained Adult Product Testers
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: CP 690,550 oral solutions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Nelfinavir, a Phase I/Phase II Rectal Cancer Study
Status: COMPLETED
Conditions: Colorectal Cancer|Colorectal Carcinoma|Colorectal Tumors|Neoplasms, Colorectal
Interventions: DRUG: nelfinavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vital Signs Patch: Automated Monitoring of Vital Signs Measurements in the In-Patient Hospital Setting
Status: COMPLETED
Conditions: Automated Measurement of Vital Signs
Interventions: DEVICE: Vital Signs Patch (VSP) System 3-Lead (NEHB) Configuration|DEVICE: Vital Signs Patch (VSP) System 1-Lead (PAL) Configuration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Proof of Mechanism of GSK2618960 in Primary Sjögren's Syndrome (pSS)
Status: WITHDRAWN
Conditions: Autoimmune Diseases
Interventions: DRUG: GSK2618960 2 mg/kg|DRUG: Placebo|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Administration of Metoprolol Versus Biatrial Pacing in the Prevention of Atrial Fibrillation After Cardiac Surgery
Status: COMPLETED
Conditions: Atrial Fibrillation|Biatrial Pacing|Metoprolol
Interventions: OTHER: metoprolol, biatrial pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Breads Made With Triticum Heritage Varieties: Effect on Post-prandial Glycemia and Insulinemia
Status: COMPLETED
Conditions: Dietary Modification
Interventions: OTHER: Bologna 00+S. cerevisiae yeast|OTHER: Bologna 1+S. cerevisiae yeast|OTHER: Bio2+S. cerevisiae yeast|OTHER: ICARDA+S. cerevisiae yeast|OTHER: Bologna 1+sourdough|OTHER: Bio 2+sourdough|OTHER: ICARDA+sourdough|OTHER: Grossi+sourdough
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Calcineurin Inhibitor-free, Steroid-free Immunosuppressive Regimen in Simultaneous Islet-Kidney Transplantation for Uremic Type 1 Diabetic Patients
Status: WITHDRAWN
Conditions: Islets of Langerhans Transplantation|Diabetes Mellitus, Type 1|Kidney Transplantation
Interventions: DRUG: Belatacept
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Physalis Child : Identification of Cognitive and Emotional Factors
Status: COMPLETED
Conditions: Auditory Hallucinations
Interventions: BEHAVIORAL: Patients with auditory hallucination|BEHAVIORAL: Patients without auditory hallucination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Flow Controlled Ventilation in Robot-assisted Laparoscopic Surgery
Status: NOT_YET_RECRUITING
Conditions: Mechanical Ventilation Complication|Postoperative Pulmonary Atelectasis
Interventions: OTHER: Flow-controlled ventilation|OTHER: Pressure-controlled ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bidirectional, Upbeat Communication and Differentiated, Distanced Care for Young People
Status: COMPLETED
Conditions: HIV Infections|Covid19|Health Care Utilization|Gender-based Violence
Interventions: BEHAVIORAL: Mobile phone support|BEHAVIORAL: Remote service delivery model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Bevacizumab and Erlotinib in Patients With Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: bevacizumab|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Mexiletine for Treating People With Non-Dystrophic Myotonia
Status: COMPLETED
Conditions: Myotonia|Non-Dystrophic Myotonia
Interventions: DRUG: Mexiletine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Cast Iron Pots to Improve Maternal Anemia
Status: TERMINATED
Conditions: Iron-deficiency Anemia
Interventions: DEVICE: Cast Iron Pot|DEVICE: Alumnium Pot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy, Bone Marrow Transplantation, and Peripheral Stem Cell Transplantation in Treating Patients With Ovarian Epithelial Cancer
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: cyclophosphamide|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Raltegravir Switch for Toxicity or Adverse Events
Status: COMPLETED
Conditions: HIV/AIDS|Antiretroviral Therapy|HIV Infections
Interventions: DRUG: tenofovir emtricitabine raltegravir|DRUG: Lamivudine Abacavir Raltegravir|DRUG: Abacavir free
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alogliptin/Pioglitazone (Liovel) Combination Tablets Survey on Long-term Use in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Alogliptin/Pioglitazone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Oxepa Enteral Feeding in LTAC (Long Term Acute Care Hospital) Patients on Chronic Ventilation- a Pilot Study
Status: UNKNOWN
Conditions: Acute Lung Injury|Mechanical Ventilation Complication|Dietary Modification
Interventions: OTHER: Oxepa|OTHER: Jevity 1.5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Retention of Pit and Fissure Sealants in Rural Setup: A School-based Clinical Trial in Nepal
Status: ENROLLING_BY_INVITATION
Conditions: Dental Caries Pit and Fissure|Oral Disease
Interventions: OTHER: Glass Ionomer cement pit and fissure sealant, Silver Diamine Fluoride
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Orally Administered L- Arginine on Quadriceps Strenght in Healthy Smokers
Status: UNKNOWN
Conditions: Spirometry|Qadriceps Muscle
Interventions: DRUG: L-Arginine, 500 Mg Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Eye Movements Desensitization and Reprocessing Intervention in Preventing Craving in Alcohol Use Disorder
Status: ENROLLING_BY_INVITATION
Conditions: Alcohol Use Disorder|Alcohol Craving
Interventions: BEHAVIORAL: addiction-focused eye movements desensitization and reprocessing (AF-EMDR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Letrozole for Estrogen/Progesterone Receptor Positive Low-grade Serous Epithelial Ovarian Cancer (LEPRE Trial)
Status: RECRUITING
Conditions: Carcinoma, Ovarian Epithelial|Low Grade Serous Adenocarcinoma of Ovary
Interventions: DRUG: Letrozole tablets|DRUG: carboplatin AUC 5 and paclitaxel 175 mg/m2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Open-label, Single-center, Single-arm Phase II Clinical Study of Cadonilimab (AK104) Combined With Monotherapy Chemotherapy in Patients With Advanced Non-small Cell Lung Cancer With Negative Driver Genes and Failed Immunotherapy
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Cadonilimab (AK104)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pegfilgrastim and Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Aggressive B-Cell Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: pegfilgrastim|BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: prednisone|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Resveratrol Trial for Relief of Pain in Pseudoachondroplasia
Status: TERMINATED
Conditions: Pseudoachondroplasia
Interventions: DRUG: resveratrol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Assessing Fosaprepitant in Advanced NSCLC Patients Treated With Carboplatin Based Chemotherapy
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer|Vomiting|Nausea|Emesis
Interventions: DRUG: FOSAPREPITANT (Emend)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of iPRF With Vit.D As an Adjunct to Non-Surgical Therapy in the Treatment of Stage III Periodontitis
Status: NOT_YET_RECRUITING
Conditions: Periodontal Pocket
Interventions: PROCEDURE: PMPR+iPRF|DRUG: PMPR+iPRF+Vit.D|PROCEDURE: PMPR only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sequential and Personalized PK-guided Busulfan Administration in the Frame of the Conditiong Regimen for Allo-HSCT in Patients With Malignant Hemopathies Ineligible for the Standard Myeloablative Conditioning
Status: NOT_YET_RECRUITING
Conditions: Acute Leukemia|Mielodysplasic Syndrome|Myeloproliferative Neoplasm
Interventions: DRUG: Busulfan Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label Safety Extension Study Assessing Safety and Tolerability of LAI in Patients Who Participated in Study INS-212
Status: COMPLETED
Conditions: NTM Lung Infection Due to MAC
Interventions: DRUG: LAI 590 mg|DRUG: Multi-drug regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Exosomes in Treating Chronic Cough After COVID-19
Status: RECRUITING
Conditions: Long COVID-19 Syndrome
Interventions: BIOLOGICAL: MSC-derived exosomes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NW Roselle in Grade 1 Essential Hypertension: Phase III Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: Essential Hypertension
Interventions: DRUG: NW Roselle|DRUG: Captopril 25Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxidative Stress and Surgical Recovery
Status: ACTIVE_NOT_RECRUITING
Conditions: Surgical Recovery|Pain, Postoperative
Interventions: DRUG: N-acetyl cysteine|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Product Feasibility of a New Silicone Hydrogel Contact Lens
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Investigational Lens|DEVICE: Acuvue Oasys Lens|DEVICE: Air Optix Aqua Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Chart Review Study to Describe the Clinical Profile of Idiopathic Pulmonary Fibrosis (IPF) Patients Treated With Nintedanib (OFEV®) in Real-world Practice in Spain
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: L - Antineoplastic and immunomodulating agents|DRUG: L01 - Antineoplastic agents|DRUG: L01X - Other antineoplastic agents|DRUG: L01XE - Protein kinase inhibitors|DRUG: L01XE31 - Nintedanib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Gut Health,Feces Characteristics and Growth of Infants Fed With a New Infant Organic Formula
Status: ACTIVE_NOT_RECRUITING
Conditions: Infant Development
Interventions: DIETARY_SUPPLEMENT: BLM ORGANIC GOLD+|DIETARY_SUPPLEMENT: BLM ORGANIC|DIETARY_SUPPLEMENT: Breast milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lapatinib (GW572016) for Metastatic or Recurrent Squamous Cell Carcinoma Esophagus
Status: TERMINATED
Conditions: Metastatic or Recurrent Squamous Cell Carcinoma of the Esophagus
Interventions: DRUG: Lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Bone Health in Adolescent Girls: The Youth Osteoporosis and Understanding Total Health (YOUTH) Study
Status: COMPLETED
Conditions: Osteoporosis
Interventions: BEHAVIORAL: Diet with increased fruits, vegetables, and calcium|BEHAVIORAL: Increased high impact activity and resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Ultrasound-Guided Needle Aspiration and Open Incision and Drainage for Cutaneous Abscesses
Status: TERMINATED
Conditions: Abscess
Interventions: PROCEDURE: ultrasound-guided needle aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Developing Microbials to Fight Extended-spectrum Beta-lactamase (ESBL)-Producing Escherichia Coli
Status: UNKNOWN
Conditions: Extended Spectrum Beta Lactamases (ESBL) E. Coli
Interventions: OTHER: examination of stool sample|OTHER: patient questionnaire|OTHER: examination of blood sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of D-Cycloserine as an Aid to Enhance Learning for Individuals With OCD Receiving Behavior Therapy
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: DRUG: seromycin|BEHAVIORAL: Behavior Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antioxidant Replacement Therapy in Patients With Alcohol Abuse
Status: COMPLETED
Conditions: Alcohol Abuse
Interventions: DIETARY_SUPPLEMENT: Protandim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Erythropoietin Protects Very Preterm Infants Against Necrotizing Enterocolitis
Status: COMPLETED
Conditions: Premature Infant
Interventions: DRUG: EPO|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vascular Effects of Mineralocorticoid Receptor Antagonism in Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease|Albuminuria
Interventions: DRUG: Spironolactone|DRUG: Amiloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prediction of Cognitive Properties of Memantine for Neurodegenerative Diseases
Status: UNKNOWN
Conditions: Alzheimer Disease|Battery
Interventions: DRUG: Memantine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Evaluation of the Lutronic PicoPlus System for the Treatment of Benign Pigmented Lesions of the Hands
Status: ACTIVE_NOT_RECRUITING
Conditions: Benign Pigmented Lesions
Interventions: DEVICE: PicoPlus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effectiveness of Anti-Arrhythmic Medications After Atrial Fibrillation Ablation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: propafenone; flecainide; sotalol; dofetilide|DEVICE: Radiofrequency catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Ixazomib and Romidepsin in Peripheral T-cell Lymphoma (PTCL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma, T-Cell, Peripheral
Interventions: DRUG: Romidepsin|DRUG: Ixazomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Efficacity of Ephedrine Versus Norepinephrine to Correct Anesthesia Induction Related Hypotension
Status: UNKNOWN
Conditions: Hypotension on Induction
Interventions: DRUG: Ephedrine|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EGFR Monoclonal Antibody for Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer|Cetuximab|Nimotuzumab
Interventions: DRUG: EGFR antibody and Chemotherapy|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lidocaine-prilocaine Cream Versus Rectal Meloxicam on Relief of Post-episiotomy Pain
Status: COMPLETED
Conditions: Postpartum
Interventions: DRUG: lidocaine-prilocaine cream|DRUG: meloxicam rectal suppository
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regorafenib in Patients With Metastatic Solid Tumors Who Have Progressed After Standard Therapy
Status: COMPLETED
Conditions: Pancreas Cancer|Ovarian Cancer|Melanoma|Sarcoma|Thymoma Type B3|Thymoma Type B2|Thymic Carcinoma
Interventions: DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Two Therapeutic Strategies in the Treatment of Children With Congenital Toxoplasmosis
Status: TERMINATED
Conditions: Congenital Toxoplasmosis
Interventions: PROCEDURE: reducing treatment to 3 months|PROCEDURE: registered length of treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Augmented Low-dye* Taping and Exercise on Plantar Pressure, Navicular Drop and Foot Posture in Pes Planus
Status: ACTIVE_NOT_RECRUITING
Conditions: Pes Planus
Interventions: OTHER: taping|OTHER: exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Coenzyme Q10 in Relation of the Lipid Peroxidation, Antioxidant Enzyme Activities in Coronary Artery Disease Patients
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DIETARY_SUPPLEMENT: Coenzyme Q10|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Probiotic Intake on Intestinal Permeability in Healthy Adults
Status: COMPLETED
Conditions: Intestinal Barrier Function
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Chemotherapy (DA-EPOCH+/-R) and Targeted Therapy (Tafasitamab) for the Treatment of Newly-Diagnosed Philadelphia Chromosome Negative B Acute Lymphoblastic Leukemia
Status: RECRUITING
Conditions: B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative
Interventions: PROCEDURE: Bone Marrow Aspiration and Biopsy|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Etoposide|DRUG: Prednisone|BIOLOGICAL: Rituximab|BIOLOGICAL: Tafasitamab|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peripheral Stem Cell Transplant in Treating Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma|Plasma Cell Neoplasm
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: CD34+ cells|DRUG: cyclophosphamide|DRUG: fludarabine phosphate|DRUG: melphalan|DRUG: methotrexate|DRUG: tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Olecranon Fractures in the Elderly
Status: RECRUITING
Conditions: Olecranon Fracture
Interventions: PROCEDURE: Tension band wiring or plate fixation|PROCEDURE: Active non-operative treatment with optional plaster cast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of a Wheat Containing Diet on Non-alcoholic Steatohepatitis
Status: COMPLETED
Conditions: NASH - Nonalcoholic Steatohepatitis|Diabetes Mellitus, Type 2|Hyperlipidemias
Interventions: OTHER: Nutritional Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BotulInum Toxin Type A for Peripheral Neuropathic Pain in subjEcts With Carpal Tunnel Syndrome
Status: UNKNOWN
Conditions: Carpal Tunnel Syndrome|Neurogenic Inflammation|Pain|Drug Use|Neuropathic Pain
Interventions: DRUG: BoNT-A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of BG00012 on MRI Lesions and Pharmacokinetics in Pediatric Subjects With RRMS
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: dimethyl fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Melatonin for Uveal Melanoma
Status: RECRUITING
Conditions: Uveal Melanoma|Uveal Melanoma, Posterior, Medium/Large Size|Eye Cancer, Intraocular Melanoma
Interventions: DRUG: Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vemurafenib, Cetuximab, and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or That Cannot Be Removed by Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: BRAF NP_004324.2:p.V600X|KRAS wt Allele|Metastatic Malignant Solid Neoplasm|Stage IV Colorectal Cancer AJCC v7|Stage IVA Colorectal Cancer AJCC v7|Stage IVB Colorectal Cancer AJCC v7|Unresectable Solid Neoplasm
Interventions: BIOLOGICAL: Cetuximab|DRUG: Irinotecan Hydrochloride|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study for Verification of Efficacy and Safety for Perampanel Monotherapy in Untreated Participants With Partial Onset Seizures (Including Secondarily Generalized Seizures (FREEDOM Study)
Status: COMPLETED
Conditions: Partial Onset Seizures
Interventions: DRUG: E2007
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Population Pharmacokinetic of Piperacillin/Tazobactam in Maternal and Neonatal Populations
Status: RECRUITING
Conditions: Early-Onset Neonatal Sepsis
Interventions: DRUG: Piperacillin Sodium and Tazobactam Sodium for Injection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Treatment for Severe Inflammatory Acne Subjects
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Adapalene 0.3% / benzoyl peroxide 2.5% emulsion gel|DRUG: Oral doxycycline hyclate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Implementation of Montessori Approaches in Person-Centered Care Within VA
Status: ACTIVE_NOT_RECRUITING
Conditions: Dementia or a Related Disorder|Mental Health Diagnoses|Symptoms of Agitation or Aggression
Interventions: BEHAVIORAL: Montessori Approaches to Person-Centered Care (MAP-VA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Respimat® Inhaler vs a Metered Dose Inhaler Using Berodual® in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: TERMINATED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Berodual® Respimat®, low inspiratory flow rate|DRUG: Berodual® Respimat®, medium inspiratory flow rate|DRUG: Berodual® Respimat®, high inspiratory flow rate|DRUG: Berodual® HFA-MDI, low inspiratory flow rate|DRUG: Berodual® HFA-MDI, medium inspiratory flow rate|DRUG: Berodual® HFA-MDI, high inspiratory flow rate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benefits of Therapy With Virtual Reality Exposure in the Treatment of Cocaine Use Disorders
Status: UNKNOWN
Conditions: Addiction|Cocaine-Related Disorders
Interventions: BEHAVIORAL: Virtual Reality-Enhanced Cognitive Behavioral Therapy (VR-CBT)|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stent Implantation Versus Balloon Dilation for Acute Anterior Circulation Tandem Occlusion
Status: RECRUITING
Conditions: Thrombectomy|Tandem Occlusion|Stroke
Interventions: DEVICE: Carotid Stenting|PROCEDURE: Thrombectomy|DRUG: Dual antiplatelet treatment|DRUG: Intraoperative Drug Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Suicide Prevention for Justice Involved Managed Care Subscribers
Status: ACTIVE_NOT_RECRUITING
Conditions: Suicide and Self-harm
Interventions: BEHAVIORAL: Caring Contacts letters|BEHAVIORAL: Reports, re-engagement, and training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Examining the Effects of Morning and Evening Exercise on Glucose Regulation in Adults With Prediabetes
Status: RECRUITING
Conditions: PreDiabetes|Obesity|Inactivity/Low Levels of Exercise
Interventions: BEHAVIORAL: AM Exercise|BEHAVIORAL: PM Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating Myosteatosis in Steatotic Liver Diseases
Status: ENROLLING_BY_INVITATION
Conditions: Alcohol-related Liver Disease|Metabolic Dysfunction Associated Steatotic Liver Disease|Steatotic Liver Disease of Mixed Origin (MetALD)|Steatotic Liver Diseases|Myosteatosis|Magnetic Resonance Imaging|Magnetic Resonance Spectroscopy|Liver Histology
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Quantitative Real-time Ultrasound Elastography for Characterisation of Liver Tumors
Status: COMPLETED
Conditions: Haemangioma|Metastases|Cholangiocellular Carcinoma|Hepatocellular Carcinoma|Focal Nodular Hyperplasia
Interventions: PROCEDURE: Shear wave elastography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Long-Term Safety and Efficacy of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Patients With Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
Status: RECRUITING
Conditions: Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
Interventions: DRUG: Eplontersen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of BMX-001 (Radio-protector) in Patients With Newly Diagnosed Anal Cancer
Status: RECRUITING
Conditions: Anal Cancer, Squamous Cell Carcinoma|Radiation Exposure
Interventions: DRUG: BMX-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transarterial Chemoembolization (TACE) vs. CyberKnife for Recurrent Hepatocellular Carcinoma (HCC)
Status: WITHDRAWN
Conditions: Recurrent Hepatocellular Carcinoma
Interventions: PROCEDURE: Transarterial Chemoembolization|RADIATION: CyberKnife SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Super 13 Pro & Prebiotics on the Human Intestinal Microflora
Status: COMPLETED
Conditions: Probiotics|Prebiotics
Interventions: DIETARY_SUPPLEMENT: Super 13 Pro & Prebiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Antenatal Vitamin D3 Dose-finding and Safety Study
Status: COMPLETED
Conditions: Pregnancy|Nutritional Status|Vitamin D
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Optic Nerve Sheath Diameter in Low-flow and Normal-flow Rate Anesthesia
Status: COMPLETED
Conditions: Intracranial Hypertension
Interventions: PROCEDURE: Low flow technique in general anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Paclitaxel Plus Bevacizumab in Patients With Chemosensitive Relapsed Small Cell Lung Cancer
Status: COMPLETED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Paclitaxel|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 1 Year Open-label Extension to CZOL446H2337 Safety and Efficacy Trial of Zoledronic Acid Twice Yearly in Osteoporotic Children Treated With Glucocorticoids
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adenomyosis and Ulipristal Acetate
Status: COMPLETED
Conditions: Adenomyosis
Interventions: DRUG: Ulipristal acetate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Dual Chamber ICD With Special Programmed Features to Lower the Risk of Inappropriate Shock
Status: COMPLETED
Conditions: Ventricular Tachycardia|Ventricular Fibrillation|Atrial Fibrillation|Supraventricular Tachycardia
Interventions: DEVICE: Dual Chamber ICD|DEVICE: Single Chamber ICD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study to Compare Metformin / Vildagliptin Versus Galvumet®
Status: COMPLETED
Conditions: Fed Conditions
Interventions: DRUG: Metformin / Vildagliptin Reference Film Coated Tablets (1000 mg / 50 mg) (Galvumet®)|DRUG: Metformin / Vildagliptin Test Film Coated Tablets (1000 mg / 50 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of BL-M07D1, BL-M07D1+Pertuzumab and BL-M07D1+Pertuzumab+Docetaxel in Patients With Unresectable Locally Advanced or Metastatic HER2-positive Breast Cancer
Status: RECRUITING
Conditions: HER2-positive Breast Cancer
Interventions: DRUG: BL-M07D1|DRUG: Pertuzumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT