pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety Study of BMS-986015 (Anti-KIR) in Combination With Ipilimumab in Subjects With Selected Advanced Tumor
Status: COMPLETED
Conditions: CANCER, NOS
Interventions: DRUG: Lirilumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of Oral OZ439 Prototype Granule Formulations Administered With Piperaquine Phosphate (PQP) Tablets
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: OZ439 + TPGS|DRUG: OZ439 Prototype 1|DRUG: OZ439 Prototype 3|DRUG: PQP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biological Therapy and Gene Therapy in Treating Children With Recurrent or Refractory Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: therapeutic autologous lymphocytes|DRUG: chemotherapy|DRUG: ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Desensitization in Kidney Allograft Using Daratumumab
Status: COMPLETED
Conditions: Allosensitization|Kidney Transplant Rejection|Antibody-mediated Rejection
Interventions: DRUG: Daratumumab dose escalation|DRUG: Daratumumab full dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Pharmacokinetics, Safety, and Tolerability of Emicizumab in Healthy Chinese Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers|Hemophilia A
Interventions: DRUG: Emicizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Clinical Effectiveness of 2 Lower Dose Combined PDE5i's vs. Single Maximal Dose PDE5i
Status: UNKNOWN
Conditions: Impotence
Interventions: DRUG: Sildenafil, Vardenafil|DRUG: Sildenafil|DRUG: Vardenafil|DRUG: Sildenafil & Vardenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Nimodipine on the Postoperative Cognitive Dysfunction
Status: TERMINATED
Conditions: Mild Cognitive Impairment
Interventions: DRUG: Nimodipine group|DRUG: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Study Assessing Haplo vs. URD in AML
Status: TERMINATED
Conditions: Acute Myeloid Leukemia
Interventions: OTHER: allogeneic stem cell transplantation with a haplo-identical family donor graft|OTHER: allogeneic stem cell transplantation with a matched unrelated donor graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of the Inactivated Koçak-19 Inaktif Adjuvanlı COVID-19 Vaccine Compared to Placebo
Status: UNKNOWN
Conditions: COVID-19 Vaccine
Interventions: BIOLOGICAL: Koçak-19 Inaktif Adjuvanlı COVID-19 Vaccine 4 µg/0.5 ml Vaccine|BIOLOGICAL: Koçak-19 Inaktif Adjuvanlı COVID-19 Vaccine 6 µg/0.5 ml Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: LY3023414 and Prexasertib in Metastatic Triple-negative Breast Cancer
Status: COMPLETED
Conditions: Triple Negative Breast Cancer
Interventions: COMBINATION_PRODUCT: Drug 1: LY3023414; Drug 2: Prexasertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FoodACT: Investigating the Impact of a School Garden Intervention on Children's Food Literacy, Climate Literacy, School Motivation and Physical Activity
Status: RECRUITING
Conditions: Physical Inactivity|Literacy|Motivation
Interventions: BEHAVIORAL: Gardens to Bellis|BEHAVIORAL: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 12 Month Follow up in Vivo Icon Study on Fluorotic Teeth
Status: WITHDRAWN
Conditions: Fluorosis|Oral Deseases
Interventions: DEVICE: Resin infiltration|DEVICE: Microabrasion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of the Vitamin D Blood Levels on the Amyotrophic Lateral Sclerosis Phenotype
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: PROCEDURE: Blood test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Inhaled Beclomethasone After Community-Acquired Respiratory Viral Infection in Lung Transplant Recipients
Status: COMPLETED
Conditions: Lung Transplant Infection
Interventions: DRUG: Inhaled beclomethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Continuous Positive Airway Pressure for Acute Pulmonary Edema
Status: COMPLETED
Conditions: Pulmonary Edema|Dyspnea|Paroxysmal|Congestive Heart Failure
Interventions: PROCEDURE: Continuous Positive Airway Pressure (CPAP)|PROCEDURE: usual care of acute pulmonary oedema
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: rTMS for Craving in Methamphetamine Use Disorder
Status: RECRUITING
Conditions: Methamphetamine Abuse|Substance Use Disorders|Stimulant Dependence|Methamphetamine-dependence|Stimulant Use|Transcranial Magnetic Stimulation
Interventions: DEVICE: Real Repetitive transcranial magnetic stimulation|DEVICE: Sham Repetitive transcranial magnetic stimulation|BEHAVIORAL: Methamphetamine visual cues|BEHAVIORAL: Neutral visual cues
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treating Bacterial Overgrowth in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease|Small Intestinal Bacterial Overgrowth
Interventions: DRUG: Rifaximin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Liver Fibrosis in Zambian HIV-HBV Co-infected Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Human Immunodeficiency Virus|HBV|Fibrosis, Liver|Cirrhosis, Liver|Hepatocellular Carcinoma|Hepatitis Delta Virus|Alcoholic Hepatitis
Interventions: DRUG: Anti-HIV Agents
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Multi-Center Trial To Evaluate The Safety And Efficacy Of Pegaptanib Sodium(Macugen) Injected Into The Eye Every 6 Weeks For Up To 2 Years For Macular Swelling Associated With Diabetes, With An Open-Label Macugen Year Extension.
Status: COMPLETED
Conditions: Macular Edema Associated With Diabetes Mellitus
Interventions: DRUG: Standard of Care|DRUG: Macugen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Effect of Secondary Prophylaxis With rFVIII Therapy in Severe Hemophilia A Adult and/or Adolescent Subjects Compared to That of Episodic Treatment
Status: COMPLETED
Conditions: Hemophilia A
Interventions: BIOLOGICAL: Recombinant Factor VIII (Kogenate FS, BAY14-2222)|BIOLOGICAL: Recombinant Factor VIII (Kogenate FS, BAY14-2222)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Oral N-Acetylcysteine in Children With Autism Spectrum Disorders
Status: COMPLETED
Conditions: Autistic Disorder|Asperger Syndrome|Child Development Disorders, Pervasive
Interventions: DRUG: N-acetylcysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ACE-083 in Patients With Facioscapulohumeral Muscular Dystrophy (FSHD)
Status: TERMINATED
Conditions: Facioscapulohumeral Muscular Dystrophy
Interventions: DRUG: ACE-083|DRUG: ACE-083 or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-Powered Negative Pressure Wound Therapy vs Open Technique for Pilonidal Disease
Status: UNKNOWN
Conditions: Pilonidal Disease|Pilonidal Sinus
Interventions: PROCEDURE: NPWT for Pilonidal Surgery|PROCEDURE: Excision of Pilonidal sinus with normal dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Nitrous Oxide Donor for Labor Induction in Women With PreEclampsia
Status: COMPLETED
Conditions: Preeclampsia|Labor, Premature
Interventions: DRUG: Monoket Pill|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Health Coaching Based Treatment Versus Usual Treatment of Systemic Arterial Hypertension and Comorbidities
Status: UNKNOWN
Conditions: Hypertension, Resistant to Conventional Therapy
Interventions: OTHER: Health Coaching|OTHER: Multiprofessional Team
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinician Decision Support Algorithm for Chemotherapy-Induced Peripheral Neuropathy
Status: COMPLETED
Conditions: Cancer|Chemotherapy-induced Peripheral Neuropathy
Interventions: BEHAVIORAL: CIPN Assessment and Management Algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Brodalumab Compared to Placebo on Vascular Inflammation in Moderate-to-severe Psoriasis
Status: UNKNOWN
Conditions: Psoriasis
Interventions: DRUG: Brodalumab|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Telerehabilitation After Arthroscopic Meniscus Repair
Status: COMPLETED
Conditions: Telerehabilitation|Meniscus Tear|Physiotherapy|Rehabilitation|Postoperative
Interventions: PROCEDURE: synchronized telerehabilitation|PROCEDURE: asynchronized telerehabilitation|PROCEDURE: supervised (face to face) rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Expiratory Muscle Training Versus Incentive Spirometry After Colorectal Surgery
Status: COMPLETED
Conditions: Colorectal Cancer|Pulmonary Rehabilitation
Interventions: OTHER: expiratory muscle training|DEVICE: Insentive spirometry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Antral Biopsies Obtained in Normal Esophagogastroduodenoscopy
Status: COMPLETED
Conditions: Gastritis H Pylori|Gastritis Chronic|Intestinal Metaplasia
Interventions: PROCEDURE: Esophagogastroduodenoscopy|PROCEDURE: Endoscopic biopsy sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: TR115 in Patients With Relapsed / Refractory Non-Hodgkin's Lymphoma or Advanced Solid Tumors
Status: RECRUITING
Conditions: Non-Hodgkin's Lymphoma, Relapsed|Non-Hodgkin's Lymphoma Refractory|Advanced Solid Tumor
Interventions: DRUG: TR115
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Duloxetine Versus Placebo in Patients Taking a Nonsteroidal Anti-inflammatory Drug (NSAID) for Knee Pain Due to Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis Knee Pain
Interventions: DRUG: Duloxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Statins for the Early Treatment of Sepsis
Status: TERMINATED
Conditions: Sepsis
Interventions: DRUG: Simvastatin|DRUG: Identical-appearing placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness Based Cognitive Therapy and Antidepressant Medication in Recurrent Depression
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: BEHAVIORAL: Mindfulness Based Cognitive Therapy|DRUG: Optimal Medical Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Light Intensity Physical Activity Trial
Status: COMPLETED
Conditions: Diabetes Mellitus|Physical Exercise|Light Intensity Physical Activity|Arterial Stiffness|Aortic Stiffness|Pulse Wave Velocity|Type2 Diabetes|Sedentary Lifestyle|Artery Disease|Physical Activity
Interventions: BEHAVIORAL: Interactive workshops LiPAT intervention group|DEVICE: Wrist-worn feedback physical activity monitor|DEVICE: Smartphone application LiPAT|BEHAVIORAL: Telephone Coaching|BEHAVIORAL: Workshops control group LiPAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Subtalar and Talocrural Joint Mobilization on Foot Ranges and Posture in Diabetic Patients
Status: COMPLETED
Conditions: Diabetic Foot
Interventions: OTHER: subtalar and talo-crural mobilization|OTHER: International Working Group of the Diabetic Foot care guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ticagrelor in Human Endotoxemia Response to Human Endotoxemia
Status: COMPLETED
Conditions: Endotoxemia
Interventions: DRUG: ticagrelor|DRUG: Clopidogrel|DRUG: Acetylsalicylic acid lysinate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: TACE Combined With Iodine-125 Seeds Implantation for HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma|Portal Vein Occlusion|Tumor Thrombus
Interventions: PROCEDURE: TACE combined with iodine-125 seeds implantation|PROCEDURE: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Virtual Reality Rehabilitation Improve Mobility, Balance, and Walking in Patients With Total Hip Arthroplasty?
Status: RECRUITING
Conditions: Total Hip Arthroplasty
Interventions: OTHER: Conventional rehabilitation|DEVICE: Virtual Reality Rehabilitation System (VRRS)|DEVICE: Virtual Reality Rehabilitation System (VRRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Asynchronies in Pediatric Noninvasive Ventilation
Status: UNKNOWN
Conditions: Pediatric Respiratory Diseases
Interventions: DEVICE: Single-Limb Turbine-Driven Ventilator|DEVICE: Double-Limb Intensive Care Unit ventilator|DEVICE: Double-Limb Turbine-Driven Ventilator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Valsartan Versus Amlodipine Effect on Left Ventricular Multidirectional Deformation and Adipocytokines Level
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: valsartan (160 mg/d)|DRUG: amlodipine (10 mg/d).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Versus Placebo in Endoscopic Retrograde Cholangiopancreatography (ERCP) Sedation
Status: COMPLETED
Conditions: Pancreatitis
Interventions: DRUG: Precedex|DRUG: sodium chlorid 0,9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Food Study of Doxycycline Monohydrate Tablets 100 mg and Adoxa Tablets 100 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Doxycycline Monohydrate Tablets 100 mg|DRUG: Adoxa Tablets 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Reducing Fluid Overload in Heart Failure Patients Using a Non-invasive, Renal Independent System
Status: NOT_YET_RECRUITING
Conditions: Chronic Heart Failure|CKD Stage 3
Interventions: DEVICE: AquaPass System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Design and Application of Special Semi Recumbent Cushion for Postoperative Patients With Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DEVICE: cushion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preload Optimization Guided by Inferior Vena Cava Collapsibility Index
Status: COMPLETED
Conditions: Adverse Effect
Interventions: DRUG: Control group|DRUG: 4 ml/kg group.|DRUG: 8 ml/kg group.|DRUG: 12 ml/kg group.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Post Market Observational Retrospective Study of Glycar Bovine Pericardial Patch (CIP-003)
Status: COMPLETED
Conditions: Cardiac Defect|Cardiac Anomaly|Pericardial Defect
Interventions: DEVICE: Glycar Pericardial Patch
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of TORS for SCCA
Status: ACTIVE_NOT_RECRUITING
Conditions: Oropharyngeal Squamous Cell Carcinoma|Supraglottic Squamous Cell Carcinoma
Interventions: PROCEDURE: Transoral robotic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gated Intensity Modulated Radiation Therapy and Concurrent Chemotherapy for Inoperable NSCLC
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: RADIATION: Fractionated radiation therapy followed by chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of QoL Between Trabectedin/PLD and Standard Platinum-based Therapy in Patients With Platinum Sensitive Recurrent Ovarian Cancer
Status: COMPLETED
Conditions: Quality of Life|Ovarian Cancer|Recurrent Ovarian Carcinoma
Interventions: DRUG: Trabectidin (Yondelis)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Conjugated Linoleic Acid as a Nutraceutical for Weight Loss in Humans
Status: COMPLETED
Conditions: Body Weight|Body Composition|Hyperlipidemia|Inflammation|Oxidative Stress
Interventions: DIETARY_SUPPLEMENT: Clarinol G-80 ® treatment|DIETARY_SUPPLEMENT: Safflower oil|DIETARY_SUPPLEMENT: G-c9, t11
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Home-Based Neurofeedback Program in Treating Participants With Chemotherapy-Induced Peripheral Neuropathy
Status: WITHDRAWN
Conditions: Neuropathy
Interventions: OTHER: Best Practice|BEHAVIORAL: Neurofeedback|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Performance Evaluation of the AutoLap System
Status: COMPLETED
Conditions: Patients Scheduled for Hernia Repair, Cholecystectomy, Right Colectomy, Nissen Fundoplication and Sigmoid Resection
Interventions: DEVICE: active laparoscope positioner (AutoLap)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Expander-2 Trial: Randomized Study to Evaluate Safety & Efficacy of the Urocross(TM) Expander System & Retrieval Sheath
Status: RECRUITING
Conditions: Benign Prostatic Hyperplasia
Interventions: DEVICE: Urocross implant|DIAGNOSTIC_TEST: Sham-control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CLL11: A Study of Rituximab With Chlorambucil or Chlorambucil Alone in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 1b)
Status: COMPLETED
Conditions: Lymphocytic Leukemia, Chronic
Interventions: DRUG: obinutuzumab|DRUG: rituximab|DRUG: chlorambucil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Versus Intraarticular Local Anesthestic and Steroids Injection for Chronic Hip Pain.
Status: UNKNOWN
Conditions: Hip Pain Chronic
Interventions: DEVICE: Cooled radiofrequency|DRUG: Intraaticular steroids and local anesthetic injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial of Angiotensin Receptor bLocker,Fimasartan, in Aortic Stenosis (ALFA Trial)
Status: UNKNOWN
Conditions: Critical Stenosis of Aortic Valve
Interventions: DRUG: Fimasartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DIETARY_SUPPLEMENT: Glycine|DIETARY_SUPPLEMENT: N-acetylcysteine|DIETARY_SUPPLEMENT: Alanine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of Peripheral Nerve Stimulator in Assessing Sensory Nerve Block Level of Spinal Anesthesia
Status: UNKNOWN
Conditions: Orthopedic Surgery-lower Leg Surgery
Interventions: DEVICE: the anticholinergic glycopyrrolate 0.1 ㎎ + 0-15 mg hyperbaric bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate Efficacy of rFVIIIFc for Immune Tolerance Induction (ITI) in Severe Hemophilia A Participants With Inhibitors Undergoing the First ITI Treatment (verITI-8 Study)
Status: COMPLETED
Conditions: Hemophilia A With Inhibitors
Interventions: BIOLOGICAL: rFVIIIFc
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Menstrual Cycle on the Results of Treadmill Exercise Test With High Sensitive Cardiac Troponin Levels After Exercise in Women
Status: RECRUITING
Conditions: Menstrual Cycle Disorder|Exercise Induced Ischemia
Interventions: DIAGNOSTIC_TEST: Exercise Treadmill Test (ETT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Modified Cormack Lehane Scores Evaluated by Laryngoscopy During Awake Versus Under General Anesthesia
Status: UNKNOWN
Conditions: Thyroid Cancer|Thyroid Nodule|Thyroid Adenoma
Interventions: PROCEDURE: Flexible fiberoptic laryngoscopy|PROCEDURE: Direct laryngoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: A Pragmatic Trial of Chronic Disease Approaches to Ameliorate Tobacco Related Cardiovascular Disease Health Disparities
Status: RECRUITING
Conditions: Tobacco Use Cessation|Cardiovascular Diseases|Tobacco Use|Smoking|Smoking Cessation
Interventions: BEHAVIORAL: Longitudinal Proactive Outreach (LPO).|BEHAVIORAL: Ask-Advice-Connect (AAC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Using Behavioral Economics to Achieve Improved Healthy Behavior Outcomes in Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer Female
Interventions: OTHER: placebo text message|OTHER: nutrition physical activity text message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preventing Taxane-related Peripheral Neuropathy, Pain and Nail Toxicity: A Prospective Self-controlled Trial Comparing Hilotherapy With Frozen Gloves in Early Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DEVICE: hilotherapy|DEVICE: frozen gloves
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System
Status: RECRUITING
Conditions: CAD
Interventions: DEVICE: MRI scan - obj 1|DEVICE: MRI scans - obj 2|DEVICE: MRI scans - obj 3|DEVICE: MRI scans - obj 4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Glycaemic Control of Biphasic Insulin Aspart 70 and 30 in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart 30|DRUG: biphasic insulin aspart 70|DRUG: biphasic human insulin 30
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Treatments in Eating Disorders
Status: TERMINATED
Conditions: Anorexia Nervosa|Bulimia Nervosa
Interventions: PROCEDURE: Transcranial magnetic stimulation|PROCEDURE: Transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: YH1 in Poorly Controlled Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: YH1 group|DRUG: placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study to Assess [18F]-ML-10 in Detecting Response of Tumors to Chemotherapy and Radiation
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung|Head and Neck Neoplasms
Interventions: OTHER: [18F]-ML-10 in conjunction with PET imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Ex-PRESSTM Mini Glaucoma Shunt to Trabeculectomy in Subjects With Open Angle Glaucoma
Status: COMPLETED
Conditions: Glaucoma
Interventions: PROCEDURE: Trabeculectomy|DEVICE: Ex-PRESS mini shunt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correlation of CGM Metrics With OGTT and Pregnancy Outcomes in Pregnant Women With or Without a High Risk for GDM
Status: RECRUITING
Conditions: Pregnancy Complications|Diabetes Mellitus|Hyperglycemic Disorder
Interventions: DEVICE: Continuous glucose monitoring device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Dose Escalation Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intravenous ALN-VSP02 In Patients With Advanced Solid Tumors With Liver Involvement
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: ALN-VSP02
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention for the Elderly With Malnutrition, Hidden Hunger and Low Skeletal Muscle Mass
Status: COMPLETED
Conditions: Malnutrition Risk in Elder
Interventions: DIETARY_SUPPLEMENT: Ensure Complete powder|OTHER: verbal nutrition education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Extra-Virgin and Refined Olive Oil on Some Cardiovascular Risk Factors
Status: COMPLETED
Conditions: Cardiovascular Risk Factor
Interventions: DIETARY_SUPPLEMENT: Extra-Virgin Olive Oil|DIETARY_SUPPLEMENT: Refined Olive Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Orthostatic Dysregulation and Associated Gastrointestinal Dysfunction in Parkinson's Disease -Treatment
Status: COMPLETED
Conditions: Autonomic Disturbances in Parkinson's Disease
Interventions: DRUG: Pyridostigmine bromide|DRUG: fludrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Zidovudine/Lamivudine and Either Nevirapine or Nelfinavir for Reduction of Mother-to-child HIV Transmission During Breastfeeding
Status: UNKNOWN
Conditions: HIV Infections
Interventions: DRUG: Zidovudine/Lamivudine and either Nevirapine or Nelfinavir|BEHAVIORAL: Breastfeeding for 6 months postpartum
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Eli Lilly's Insulin Dosing Algorithm to Control Glycemia in Insulin-treated Adults With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Insulin closed-loop
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conduction System Pacing vs Biventricular Pacing in Systolic Dysfunction and Wide QRS: Mortality, Heart Failure Hospitalization or Cardiac Transplant
Status: RECRUITING
Conditions: Cardiac Resynchronization Therapy|Heart Failure
Interventions: PROCEDURE: Conduction system pacing|PROCEDURE: Biventricular pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Compassionate Use of Metvix® (Methyl Aminolevulinate) Photodynamic Therapy (PDT) in Subjects With Field Actinic Keratoses, Large/Multiple Superficial Basal Cell Carcinomas (BCCs), or Bowen's Disease
Status: NO_LONGER_AVAILABLE
Conditions: Field Actinic Keratoses|Basal Cell Carcinoma|Bowen's Disease
Interventions: DRUG: Metvix (methyl aminolevulinate)
Study Type: EXPANDED_ACCESS
Clinical trial: Evaluation of the Cardioprotective Effect of Dapagliflozin on Anthracyclines-Induced Cardiotoxicity in Breast Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Dapagliflozin 10mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vandetanib and Sirolimus in Patients With Recurrent Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: Sirolimus|DRUG: Vandetanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Functional Outcomes in Individuals Using Micro-processor Controlled Orthosis Versus Stance Control Orthosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Cord Injuries|Poliomyelitis|Post-polio Syndrome|Arthritis|Lower Motor Neurone Lesion
Interventions: DEVICE: C-brace|DEVICE: Stance control orthosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Approach-Avoidance Conflict-a Multi-level Predictor for Therapy Response
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: BEHAVIORAL: Exposure-based therapy|BEHAVIORAL: Behavioral Activation therapy|BEHAVIORAL: Computer-based behavioral assessment|BEHAVIORAL: Surveys and Interviews|DEVICE: Magnetic resonance imaging (MRI)|DEVICE: Electroencephalography (EEG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: QUantum Genomics Incremental Dosing in Heart Failure - QUID-HF
Status: TERMINATED
Conditions: Heart Failure
Interventions: DRUG: QGC001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rural Home Hospital: Proof of Concept
Status: COMPLETED
Conditions: Infection|Heart Failure|Chronic Obstructive Pulmonary Disease|Asthma|Gout Flare|Chronic Kidney Diseases|Hypertensive Urgency|Atrial Fibrillation Rapid|Anticoagulants; Increased
Interventions: OTHER: Home hospital care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-Human Trial of a Novel Endoluminal Robotic System for En-Bloc Resection of Bladder Tumours
Status: NOT_YET_RECRUITING
Conditions: Bladder Cancer
Interventions: PROCEDURE: En-Bloc Resection of Bladder Tumours
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lornoxicam vs. Paracetamol After Lower Abdominal Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: OTHER: placebo|DRUG: Paracetamol|DRUG: Lornoxicam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Intranasal Kovacaine Mist, and Placebo for Anesthetizing Maxillary Teeth in Adults
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Tetracaine HCl 3% and Oxymetazoline HCl 0.05%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Exercise on Quality of Life and Physical Function in Patients With Knee Osteoarthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis|Pain
Interventions: OTHER: Strength training|OTHER: Aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Preterm Birth in Pregnant Women at Risk Identified by Ultrasound: Evaluation of Two Treatment Strategies
Status: COMPLETED
Conditions: Early Onset of Delivery Before 37 Weeks
Interventions: DRUG: Vaginal micronized progesterone|DEVICE: Cervical pessary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Improving Functional Disability and Cognition in Parkinson Disease: Randomized Controlled Trial
Status: COMPLETED
Conditions: PARKINSON DISEASE (Disorder)
Interventions: OTHER: cognitive remediation program: REHACOP|OTHER: Occupational Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Broad-spectrum Antibiotic Prophylaxis in Tumor and Infected Orthopedic Surgery
Status: RECRUITING
Conditions: Surgical Site Infection|Microbial Colonization|Antibiotic Resistant Infection
Interventions: DRUG: Standard antibiotic prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Effect of Anesthesia on Post-operative Delirium in Elderly Patients Undergoing Hip Fracture Surgery
Status: COMPLETED
Conditions: Post Operative Delirium
Interventions: PROCEDURE: method of anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prospective Exploratory Study to Assess the Effects of the AlphaCore® Device in Patients With COPD
Status: COMPLETED
Conditions: COPD
Interventions: RADIATION: Low dose multislice CT thorax|DEVICE: AlphaCore® device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ameliorating Attention Problems in Children With Sickle Cell Disease (SCD)
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of First-line Pembrolizumab (MK-3475) With Lenvatinib (MK-7902/E7080) in Urothelial Carcinoma Cisplatin-ineligible Participants Whose Tumors Express Programmed Cell Death-Ligand 1 and in Participants Ineligible for Platinum-containing Chemotherapy (MK-7902-011/E7080-G000-317/ LEAP-011)
Status: COMPLETED
Conditions: Urothelial Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Lenvatinib|DRUG: Placebo for lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety, Efficacy,and Pharmacokinetics of Orally Administered Prolectin-M
Status: NOT_YET_RECRUITING
Conditions: COVID-19|SARS CoV 2 Infection
Interventions: DRUG: Prolectin-M
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Nestle Impact Advanced Recovery in Improving Surgery Recovery in Patients With Head and Neck Cancer
Status: WITHDRAWN
Conditions: Head and Neck Carcinoma
Interventions: OTHER: Best Practice|OTHER: Laboratory Biomarker Analysis|DIETARY_SUPPLEMENT: Nutritional Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intensive Neurorehabilitation for Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: PROCEDURE: Intensive Neurophysiological Rehabilitation System|PROCEDURE: Activity and care as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Of The Effect Of CJ-023,423 On The Incidence Of Stomach Ulcers
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: CJ-023,423|DRUG: placebo|DRUG: naproxen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Neoadjuvant Therapy With Carboplatin, Paclitaxel Combined With Anti-PD-1 Drugs on Cognitive Function in Patients With Resectable Head and Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Carboplatin（ neoadjuvant）|DRUG: Paclitaxel （neoadjuvant）|DRUG: Anti-PD-1 Drugs|PROCEDURE: Surgical resection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of LY2605541 Versus Insulin Glargine on Blood Sugar
Status: COMPLETED
Conditions: Healthy Volunteers|Diabetes Mellitus, Type 1
Interventions: DRUG: LY2605541|OTHER: Insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Beyond the Self and Back: Neuropharmacological Mechanisms Underlying the Dissolution of the Self
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Placebo|DRUG: Psilocybine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Role of Antibiotics to Reduce Infectious Complications in Tube Thoracotomy Management of Traumatic Hemopneumothorax
Status: COMPLETED
Conditions: Hemopneumothorax|Pneumothorax
Interventions: DRUG: Ancef or Clindamycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Psychosocial Support in Treating Women With Recurrent Breast Cancer or Stage I, Stage II, or Stage IV Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Psychosocial Effects of Cancer and Its Treatment
Interventions: OTHER: counseling intervention|OTHER: educational intervention|PROCEDURE: psychosocial assessment and care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Role of Music in Palliative Care: A Proposal for a Rural Based Initiative in Music Based Interventions
Status: COMPLETED
Conditions: Improved Emotional Regulation|Improvement in Quality of Life|Symptom Relief|Preservation of Dignity|Existential Solace|Relief of Suffering|Emotional Regulation|Quality of Life|Dignity
Interventions: BEHAVIORAL: preferred music
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Selective Avoidance of Nodal VolumEs at Minimal Risk (GCC 20110)
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer|Oropharynx Cancer|Oropharyngeal Squamous Cell Carcinoma
Interventions: RADIATION: Intensity modulated radiotherapy (IMRT)/volumetric modulated arc therapy (VMAT) or Pencil beam proton therapy (PBPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Broccoli Sprouts Homogenate on SS RBC
Status: COMPLETED
Conditions: Sickle Red Blood Cell|Fetal Hemoglobin|Oxidative Stress
Interventions: DIETARY_SUPPLEMENT: Broccosprouts® (Brassica Protection Products LLC) homogenate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Controlled Comparison of Pre-op TLIP vs Intra-op TLIP
Status: RECRUITING
Conditions: Pain|Spine Fusion
Interventions: PROCEDURE: Preoperative Ultrasound TLIP|PROCEDURE: Intraoperative TLIP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telmisartan (Micardis) and Amlodipine (Norvasc) - Factorial Design Study for the Treatment of Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Amlodipine 5 mg|DRUG: Placebo|DRUG: Telmisartan 20 mg|DRUG: Telmisartan 40 mg|DRUG: Amlodipine 10 mg|DRUG: Telmisartan 20 mg|DRUG: Telmisartan 80 mg|DRUG: Amlodipine 10 mg|DRUG: Telmisartan 20 mg|DRUG: Amlodipine 5 mg|DRUG: Amlodipine 5 mg|DRUG: Telmisartan 20 mg|DRUG: Amlodipine 5 mg|DRUG: Amlodipine 5 mg|DRUG: Amlodipine 2.5 mg|DRUG: Amlodipine 2.5 mg|DRUG: Amlodipine 10 mg|DRUG: Amlodipine 2.5 mg|DRUG: Telmisartan 80 mg|DRUG: Telmisartan 80 mg|DRUG: Amlodipine 5 mg|DRUG: Amlodipine 2.5 mg|DRUG: Telmisartan 40 mg|DRUG: Telmisartan 40 mg|DRUG: Amlodipine 5 mg|DRUG: Amlodipine 5 mg|DRUG: Telmisartan 40 mg|DRUG: Telmisartan 80 mg|DRUG: Amlodipine 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Multimodal Analgesia in Major Abdominal Pediatric Cancer Surgeries
Status: COMPLETED
Conditions: Pediatric Cancer|Pain, Postoperative
Interventions: DRUG: Paracetamol and ketamine|PROCEDURE: Caudal levobupivacaine|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose-Escalating Trial Using Vero Cell-culture Derived H5N1 +/- Aluminum in Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Aluminum hydroxide|BIOLOGICAL: Inactivated Vero cell based whole virus influenza A/H5N1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Compare the Pharmacokinetic Profiles of Etravil® Tablet 10mg and Etravil® Tablet 25mg
Status: COMPLETED
Conditions: Depression|Depressive State|Enuresis
Interventions: DRUG: DWETR10|DRUG: DWETR25
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Lung Adenocarcinoma With Bronchioloalveolar Feature
Status: COMPLETED
Conditions: Pneumonic-type Adenocarcinoma (P-ADC)|Lung Adenocarcinoma With Bronchiolo-alveolar Feature
Interventions: DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Fluorouracil and Imiquimod in Treating Patients With High-Grade Cervical Intraepithelial Neoplasia
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia Grade 2/3|Cervical Squamous Cell Carcinoma In Situ|Cervical Squamous Intraepithelial Neoplasia 2|High Grade Cervical Intraepithelial Neoplasia
Interventions: DRUG: Imiquimod|DRUG: Topical Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT