pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Management of the PDA Trial
Status: RECRUITING
Conditions: Infant, Premature|Patent Ductus Arteriosus|Infant, Newborn, Diseases|Patent Ductus Arteriosus After Premature Birth
Interventions: OTHER: Active Treatment|OTHER: Expectant Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Four-period Crossover Study to Assess the Effects of Single Oral Doses of ZD4054 (Zibotentan) (10mg and 30mg) on QTc Interval
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ZD4054|DRUG: Moxifloxacin|DRUG: ZD4054 Placebo|DRUG: Moxifloxacin placebo|DRUG: ZD4054 Placebo|DRUG: ZD4054|DRUG: ZD4054
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Pharmacokinetics and Safety of YHD1119 in Subjects With Renal Impairment and Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteer|Renal Impairments
Interventions: DRUG: YHD1119 75mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Refining MDR-TB Treatment (T) Regimens (R) for Ultra(U) Short(S) Therapy(T)
Status: ACTIVE_NOT_RECRUITING
Conditions: Multidrug Resistant Tuberculosis
Interventions: DRUG: PZA sensitivity guided ultra-short all Oral Regimen|DRUG: Standardized Shorter Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gut Microbiota and Antibiotics - Prevention of Side Effects by New Prebiotics
Status: UNKNOWN
Conditions: Changes in the Gut Microbiota During an Antibiotic Treatment
Interventions: DIETARY_SUPPLEMENT: Prebiotic product|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate Efficacy, Safety, and Tolerability of MT-7117 in Subjects With Erythropoietic Protoporphyria
Status: COMPLETED
Conditions: Erythropoietic Protoporphyria (EPP)
Interventions: DRUG: MT-7117 low dose|DRUG: MT-7117 high dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Evaluate the Safety and Tolerability of PBI-4050 in Patients With Idiopathic Pulmonary Fibrosis (IPF)
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis (IPF)
Interventions: DRUG: PBI4050
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Compare the Pharmacokinetics and Pharmacodynamics After Oral Administration of Glucophage and HL-018
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Glucophage 500mg|DRUG: HL-018 500mg|OTHER: No administration of Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Behavioral Therapy and Self-care vs Thermoformed Occlusal Splints in the Treatment of Masticatory Muscles Pain
Status: COMPLETED
Conditions: Myalgia of Mastication Muscle
Interventions: BEHAVIORAL: behavioral and self-care therapy|DEVICE: rigid occlusal splint (ROS)|DEVICE: soft occlusal splint (SOS)|DEVICE: non-occlusive splint (NOS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COSMO Post Approval Registry: Corox OTW Steroid LV Lead Monitoring
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: DEVICE: Corox OTW Steroid Left Ventricular Lead
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OCT vs IVUS vs QCA to Guide Moderate-to-severe Calcified Lesion Stent Implantation
Status: RECRUITING
Conditions: Optical Coherence Tomography|Intravascular Ultrasound|Angiography
Interventions: DEVICE: OCT guidance|DEVICE: IVUS guidance|DEVICE: QCA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DENEX, Renal Denervation Therapy, in Patients With Hypertension on no or 1-3 Antihypertensive Medications
Status: RECRUITING
Conditions: Hypertension|Vascular Diseases|Cardiovascular Diseases
Interventions: DEVICE: Renal Denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of ETC-1002, Ezetimibe, and the Combination in Hypercholesterolemic Patients
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: ETC-1002|DRUG: Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Placental Removal Method And Uterine Massage On Preventing Postpartum Hemorrhage
Status: NOT_YET_RECRUITING
Conditions: Postpartum Hemorrhage|Cesarean Section Complications|Uterine Atony
Interventions: PROCEDURE: Manual Removal 1|PROCEDURE: Manual Removal 2|PROCEDURE: Controlled Cord Traction 1|PROCEDURE: Controlled Cord Traction 2|PROCEDURE: Controlled Cord Traction+Uterine Massage 1|PROCEDURE: Controlled Cord Traction+Uterine Massage 2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ISTH/ANRS 0409s INTEGRATE Lassa Fever Study
Status: NOT_YET_RECRUITING
Conditions: Lassa Fever
Interventions: DRUG: Favipiravir|DRUG: Ribavirin|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy and Safety in Patients With Primary Hypercholesterolemia
Status: COMPLETED
Conditions: Primary Hypercholesterolemia
Interventions: DRUG: Livalo, Ezetrol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Humoral and Cellular Immunity in First-cycle SARS-CoV-2 Vaccinated COVID-19 Patients
Status: COMPLETED
Conditions: SARS CoV 2 Infection|COVID-19
Interventions: DIAGNOSTIC_TEST: LIAISON SARS-CoV-2 TrimericS IgG (DiaSorin)|DIAGNOSTIC_TEST: LIAISON SARS-CoV2-IgM (DiaSorin)|DIAGNOSTIC_TEST: Human IFN-g ELISpot PLUS (ALP) (AUROGENE)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prognostic Impact of Tumor Growth Velocity in Head and Neck Squamous Cell Carcinoma Treated by Radio(Chemo)Therapy
Status: NOT_YET_RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma|Tumor Growth
Interventions: OTHER: Tumor delineation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: E-Stim and Achilles Tendon Repair Study
Status: COMPLETED
Conditions: Achilles Tendon Rupture
Interventions: DEVICE: Compex® muscle stimulator|DEVICE: (inactive) muscle stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: 17-AAG and Irinotecan in Treating Patients With Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: tanespimycin|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MAAM Study: Avastin and Macugen Versus Avastin Versus Macugen
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DRUG: intravitreal injection of Bevacizumab (Avastin)|DRUG: Pegaptanib (Macugen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Fairytales on Preschool Children With Attention Deficit Hyperactivity Disorder
Status: UNKNOWN
Conditions: Developmental Delay|Preschool Children|Attention Deficit Hyperactivity Disorder
Interventions: OTHER: Traditional rehabilitation programs with Individualized fairytales class
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Esophageal Arterial Infusion Chemotherapy Versus Systemic Intravenous Chemotherapy for Resectable Locally Advanced Esophageal Squamous Cell Carcinoma: a Prospective, Multicentre, Randomised Controlled Clinical Study
Status: UNKNOWN
Conditions: Resectable Locally Advanced Esophageal Squamous Cell Carcinoma
Interventions: PROCEDURE: Esophageal arterial infusion chemotherapy|DRUG: Systemic intravenous chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Dry Eye Disease After Cataract Surgery With Topical Hyaluronic Acid and Gingko Biloba
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DEVICE: Trium eyedrops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study for Endometrial Carcinoma and Hyperplasia in Childbearing-age Women
Status: RECRUITING
Conditions: Endometrial Cancer Stage I|Endometrial Hyperplasia
Interventions: DRUG: Megestrol Acetate 40 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Chemotherapy (Gemcitabine and Erlotinib) With or Without Radiation Therapy
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: Gemcitabine|RADIATION: Radiation Therapy|DRUG: Erlotinib|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease (COPD): the Development and Feasibility of an Education Package
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: LWWCOPD for Pulmonary Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Digi-physical Support During Breastfeeding Initiation
Status: RECRUITING
Conditions: Breastfeeding|Self Efficacy|Breastfeeding Duration|Depression
Interventions: OTHER: Digi-physical breastfeeding support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Heat Therapy in Treating Patients With Unresectable Primary or Metastatic Liver Cancer
Status: COMPLETED
Conditions: Liver Cancer|Metastatic Cancer
Interventions: PROCEDURE: Radiofrequency Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ResIlience-based Stigma REdUction Program ("Rise-up")
Status: NOT_YET_RECRUITING
Conditions: HIV/AIDS|Stigma, Social|Emotional Adjustment
Interventions: BEHAVIORAL: PLWH intervention|BEHAVIORAL: Family member intervention|BEHAVIORAL: Healthcare provider intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Feasibility of a Deep Learning-based Algorithm for Non-invasive Assessment of Vulnerable Coronary Plaque
Status: NOT_YET_RECRUITING
Conditions: Chronic Coronary Syndrome|Coronary Artery Disease|Stable Angina|Acute Coronary Syndrome
Interventions: OTHER: Deep Learning-based Vulnerable Plaque Detection and Assessment Tool
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Efficacy, Immunogenicity and Safety in a Sporozoite Challenge Model of a Fractional Booster Dose of GSK Biologicals' Candidate Malaria Vaccine Administered to Previously Vaccinated Healthy Malaria-naïve Adults
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: RTS,S/AS01E (SB257049)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of the Safety, Imaging and Clinical Outcomes of THR-18 in Acute Stroke Subjects Treated With tPA
Status: UNKNOWN
Conditions: Ischemic Stroke
Interventions: DRUG: THR-18|DRUG: Placebo|DRUG: Tissue Plasminogen Activator (tPA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Emotional Freedom Technique on Anxiety Levels of Nurses Caring for COVID19 Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: EFTs|Nursing Caries|Anxiety
Interventions: BEHAVIORAL: Emotional Freedom Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pilot Study: Lactoferrin for Prevention of Neonatal Sepsis
Status: COMPLETED
Conditions: Sepsis
Interventions: DIETARY_SUPPLEMENT: lactoferrin|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Pegcetacoplan in Pediatric Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)
Status: RECRUITING
Conditions: Paroxysmal Nocturnal Hemoglobinuria (PNH)|Paroxysmal Hemoglobinuria
Interventions: DRUG: Pegcetacoplan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial of a Pre-Transplant Education Intervention
Status: COMPLETED
Conditions: Kidney Transplant|Patient Education|Quality of Life
Interventions: BEHAVIORAL: electronic video education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study to Evaluate the Performance of Synthetic Polyurethane Male Condoms
Status: ACTIVE_NOT_RECRUITING
Conditions: Performance of Synthetic Polyurethane Male Condom
Interventions: DEVICE: Condom
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Feasibility of Autologous Endothelial Progenitor Cells Transplantation in Patients With Idiopathic Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Idiopathic Pulmonary Arterial Hypertension
Interventions: PROCEDURE: Transplantation of autologous endothelial progenitor cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Combination of Two Anti-cancer Drugs, Peposertib (M3814) and M1774 for Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm|Unresectable Malignant Solid Neoplasm
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Peposertib|PROCEDURE: Positron Emission Tomography|DRUG: Tuvusertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravesical Ty21a for the Treatment of Patients With Non-muscle-invasive Bladder Cancer (NMIBC)
Status: UNKNOWN
Conditions: Non Muscle Invasive Bladder Cancer
Interventions: BIOLOGICAL: Ty21a
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Urica Cor Intervention (URICORI) Trial
Status: WITHDRAWN
Conditions: Gout|Cardiovascular Diseases|Dyslipidemias|Hypertension|Diabetes|Behavior, Smoking
Interventions: OTHER: URICORI|OTHER: CONTROL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medtronic Reveal LINQ™ In-Office 2 (RIO 2) Study United States
Status: COMPLETED
Conditions: Arrhythmia
Interventions: OTHER: office setting|OTHER: hosptial setting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Functional Outcome of Urethral Reconstructive Surgery
Status: COMPLETED
Conditions: Urethral Stricture
Interventions: PROCEDURE: end-to-end urethroplasty|PROCEDURE: substitution urethroplasty (buccal mucosa)|PROCEDURE: substitution urethroplasty (pedicled skin flap)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Animation Video on the Success Rate of Children Swallowing Capsule Endoscopy
Status: COMPLETED
Conditions: Capsule Endoscopy
Interventions: OTHER: animation videos|OTHER: explanation about endoscopy endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of the Efficiency of Maxillary Canine Retraction Using Aligners Versus Conventional Brackets in Orthodontic Extraction Cases.
Status: UNKNOWN
Conditions: Removable Aligners, Conventional Brackets
Interventions: DEVICE: Removable Clear Aligners
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Intracanal Cryotherapy on Endodontic Postoperative Pain
Status: COMPLETED
Conditions: Dental Pulp Necroses|Apical Periodontitis|Post Operative Pain
Interventions: OTHER: cold saline|OTHER: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of Armed, Activated T-Cells in Patients With Advanced Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer|Advanced Pancreatic Cancer|Pancreatic Adenocarcinoma|Pancreatic Neoplasms
Interventions: DRUG: anti-EGFR-bispecific antibody armed activated T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Pharmacokinetics of IV Diclofenac Sodium (2 Doses)Versus Oral Diclofenac Potassium
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Intravenous diclofenac sodium (DIC075V) 18.75 mg|DRUG: Intravenous diclofenac sodium (DIC075V) 37.5 mg|DRUG: Oral diclofenac potassium 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Nasal High Flow Versus Oxygen for Positive Airway Pressure Non-Compliance Sleep Apnea Patients
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Low flow oxygen via nasal cannula|DEVICE: Humidified Nasal High Flow Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AC vs TC in Patients With HR-positive, HER2-negative Early Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Chemotherapeutic Toxicity
Interventions: DRUG: Liposomal doxorubicin + Cyclophosphamide vs Docetaxel + Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Curcumin Bioavailability
Status: COMPLETED
Conditions: Safety After Oral Intake|Pharmacokinetics After Oral Intake
Interventions: DIETARY_SUPPLEMENT: Native turmeric extract|DIETARY_SUPPLEMENT: Native turmeric extract with 7-9% volatile turmeric oils|DIETARY_SUPPLEMENT: Turmeric extract plus mixture of phytochemicals|DIETARY_SUPPLEMENT: Cyclodextrin complex of curcuminoids|DIETARY_SUPPLEMENT: Turmeric oleoresin|DIETARY_SUPPLEMENT: Liposomal curcumin|DIETARY_SUPPLEMENT: Phytosomal curcumin|DIETARY_SUPPLEMENT: Micellar turmeric extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of EUS-guided Celiac Plexus Blockade in Chronic Pancreatitis
Status: COMPLETED
Conditions: Chronic Pancreatitis
Interventions: DRUG: Triamcinolone|DRUG: Bupivicaine alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects Of Consumption Of A Highly Mineralized Sodium Bicarbonated Water On Blood Lipid Profile
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: OTHER: sparkling highly mineral bicarbonated sodium water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Abuse Potential of NEURONTIN® When Taken Orally in Healthy Non-drug Dependent Participants With Sedative Drug Abuse Experience
Status: COMPLETED
Conditions: Abuse Potential
Interventions: DRUG: gabapentin 600 mg|DRUG: gabapentin 1200 mg|DRUG: gabapentin 1800 mg|DRUG: diazepam 20 mg|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Alveolar Ridge Preservation After Tooth Extraction Using Autologous Dentin Matrix
Status: RECRUITING
Conditions: To Evaluate the Quality of the Newly Formed Cortical Tissue in the Area of the Condylar Condyle Using Different Bone Grafting Materials
Interventions: PROCEDURE: Alveolar Ridge Preservation After Tooth Extraction Using Autologous Dentin Matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Choice of Tube Extremity in Emission of Lowest Radiation Dose in Pediatric Patients
Status: COMPLETED
Conditions: Radiation Absorption|Radiography
Interventions: OTHER: Thyroid facing the anode end of xray machine|OTHER: Thyroid facing the cathode end of xray machine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: A Study Measuring Effect of LY2140023 (Pomaglumetad Methionil) on Electrocardiographs in Participants With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenic Disorders
Interventions: DRUG: LY2140023|DRUG: Placebo|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Learn How BAY94-8862 Moves Into, Through and Out of the Body, How Safe it is and How it Affects the Body in Adult Participants With Reduced Kidney Function and in Healthy Participants With Similar Age, Weight and Gender Distribution
Status: COMPLETED
Conditions: Worsening Chronic Heart Failure|Chronic Kidney Disease
Interventions: DRUG: Finerenone (BAY94-8862)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase II Study of Oral Nafithromycin in CABP
Status: COMPLETED
Conditions: Community-Acquired Bacterial Pneumonia (CABP)
Interventions: DRUG: Nafithromycin 800 mg 3 days|DRUG: Nafithromycin 800 mg 5 days|DRUG: Moxifloxacin 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of PEG-Intron and Two Different Doses of Ribavirin for the Treatment of Chronic Hepatitis C In Treatment Naïve Subjects
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Ribavirin, PEG-Intron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma of the Collecting Ducts of Bellini|Chromophobe Renal Cell Carcinoma|Kidney Medullary Carcinoma|Kidney Oncocytoma|Metastatic Renal Cell Cancer|Papillary Renal Cell Carcinoma|Recurrent Renal Cell Carcinoma|Sarcomatoid Renal Cell Carcinoma|Stage IV Renal Cell Cancer
Interventions: DRUG: Pazopanib Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating SC291 in Subjects With Severe r/r B-cell Mediated Autoimmune Diseases (GLEAM)
Status: RECRUITING
Conditions: Lupus Erythematosus|Systemic Lupus Erythematosus|SLE (Systemic Lupus)|Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis|Granulomatous Polyangiitis|Microscopic Polyangiitis
Interventions: BIOLOGICAL: SC291
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Nurse Practitioner Led-Care on Quality of Life in Patients With Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: OTHER: Nurse Practitioner Led-Care|OTHER: Cardiologist Led-Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Acute and Long-Term Antidepressant Treatment Success in Adolescents With Anxiety (AtLAS-A)
Status: RECRUITING
Conditions: Anxiety|Depressive Symptoms
Interventions: DRUG: Duloxetine|DRUG: Escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Peritoneal Dialysis as an Option of Unplanned Initiation of Chronic Dialysis
Status: UNKNOWN
Conditions: Disorders Associated With Peritoneal Dialysis
Interventions: OTHER: HD treatment|OTHER: PD treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Enadenotucirev and PD-1 Inhibitor in Subjects With Metastatic or Advanced Epithelial Tumors
Status: COMPLETED
Conditions: Colorectal Cancer|Squamous Cell Carcinoma of the Head and Neck|Epithelial Tumor
Interventions: BIOLOGICAL: enadenotucirev|BIOLOGICAL: nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Music Therapy as a Complementary Intervention in the Treatment of Pediatric Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: OTHER: One time music therapy|OTHER: Group music therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: a Study Evaluating the Safety and Efficacy of Clevidipine for Patients Who With Hypertensive Emergency and Sub-emergency
Status: NOT_YET_RECRUITING
Conditions: Hypertensive Emergency
Interventions: DRUG: QLG2071|DRUG: Cleviprex®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of N91115 in Patients With Cystic Fibrosis Homozygous F508del-CFTR Mutation
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: N91115
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of the Suture-Mediated Closure System
Status: RECRUITING
Conditions: Peripheral Arterial Disease|Arterial Puncture
Interventions: DEVICE: the Suture-Mediated Closure System|DEVICE: Perclose ProGlide Suture-Mediated Closure System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BIBW 2992 and BSC Versus Placebo and BSC in Non-small Cell Lung Cancer Patients Failing Erlotinib or Gefitinib (LUX-LUNG 1)
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: placebo|DRUG: BIBW 2992
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: of Sodium Glucose Cotransporter-2 Inhibitors on Metabolic, Hormonal and Clinical Parameters in PCO
Status: RECRUITING
Conditions: PCO
Interventions: DRUG: Dapagliflozin 5 MG|DRUG: Metformin Hydrochloride 1000 MG|DRUG: Dapagliflozin/Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Curcumin + Aminosalicylic Acid (5ASA) Versus 5ASA Alone in the Treatment of Mild to Moderate Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DIETARY_SUPPLEMENT: Curcumin|DRUG: 5-aminosalicylic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Study Comparing EUS vs ERCP Stent Insertion for Malignant Biliary Obstruction
Status: COMPLETED
Conditions: Tumor Appearance of Biliary System Obstruction
Interventions: PROCEDURE: ERCP-guided stent insertion|PROCEDURE: EUS guided stent insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunophenotypage of RIF and RM Patients and Intrauterine Administration of PBMC
Status: WITHDRAWN
Conditions: Infertility, Female
Interventions: PROCEDURE: Intrauterine administration of hCG-activated peripheral blood mononuclear cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Milk Supplementation and Bone Health in Children
Status: UNKNOWN
Conditions: Bone Density Increased|Body Height
Interventions: DIETARY_SUPPLEMENT: Formula milk|DIETARY_SUPPLEMENT: Regular milk|OTHER: Control foods
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Holmium Laser Versus Thulium Laser Versus Bipolar Enucleation of the Prostate.
Status: COMPLETED
Conditions: Prostate Hypertrophy|Holmium Laser|Thulium Laser|Bipolar Diathermy|Prostate Enucleation
Interventions: PROCEDURE: Holmium Laser|PROCEDURE: Thulium Laser|PROCEDURE: Bipolar diathermy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Supplementation in HIV Patients With Therapeutic Lifestyle Change Diet.
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: DIETARY_SUPPLEMENT: Omega-3 fatty acids|BEHAVIORAL: TLC nutritional intervention|DIETARY_SUPPLEMENT: Omega-3 fatty acid supplementation with fish oil and TLC nutritional intervention.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Nephrotoxicity and Hospital Costs in Patients With Methicillin-Resistant Staphylococcus Aureus Bacteremia Who Received Vancomycin Versus Teicoplanin Therapy
Status: UNKNOWN
Conditions: Staphylococcus Aureus|Bacteremia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose Finding Study of Ibrutinib Plus Lenalidomide / Rituximab in Relapsed or Refractory Mantle Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Lenalidomide|DRUG: Ibrutinib|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Bisoprolol and Atenolol on Sympathetic Nervous Activity and Central Aortic Pressure in Patients With Essential Hypertension
Status: COMPLETED
Conditions: Untreated Essential Hypertension
Interventions: DRUG: bisoprolol|DRUG: atenolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Enhanced, Demand-side Sanitation and Hygiene Promotion on Sustained Behavior Change and Health in Ethiopia
Status: COMPLETED
Conditions: Sustained Behavior Change|Mental Well-being
Interventions: BEHAVIORAL: Enhanced demand-side sanitation, hygiene|BEHAVIORAL: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Trial of Citicoline Therapy in Patients With Mania or Hypomania and Cocaine Abuse/Dependence
Status: COMPLETED
Conditions: Mania|Hypomania|Cocaine Abuse|Cocaine Dependence
Interventions: DRUG: Citicoline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Through-the-Needle With Suture-Method Catheter Designs for Popliteal Nerve Blocks
Status: COMPLETED
Conditions: Regional Anesthesia|Sciatic Nerve Block
Interventions: DEVICE: Suture-Method Technique|DEVICE: Through-the-Needle Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Vitamin D Replacement Therapy On Serum Leptin And Follicular Growth Pattern In Women With Resistant Polycystic Ovary
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Vitamin D|DRUG: Clomiphene Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NextStep:Study to Evaluate Safety,Efficacy & Tolerability of Rivastigmine Patch in Mild to Moderate Alzheimer's Patients.
Status: COMPLETED
Conditions: Mild to Moderate Alzheimer's Disease
Interventions: DRUG: Rivastigmine Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Underwater" Technique With Submucosal Solution of Viscose Solution -SIC 8000 (EleviewTM) - For Endoscopic Resection of Cole-rectal Polyps With Signs of Fibrosis.
Status: COMPLETED
Conditions: Colo-rectal Polyps
Interventions: PROCEDURE: "Underwater" mucosectomy with submucosal injection of viscous solution -SIC 8000 (EleviewTM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epigenetic Reprogramming in Relapse/Refractory AML
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia
Interventions: DRUG: Decitabine|DRUG: Vorinostat|DRUG: Filgrastim (G-CSF)|DRUG: Fludarabine|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Treatment Modalities in the Management of the Painful Crisis in Pediatric Sickle- Cell Anemia
Status: COMPLETED
Conditions: Vaso-occlusive Crisis|Sickle Cell Disease|Sickle Cell Anemia in Children
Interventions: DRUG: Omega 3|DRUG: Vit D|DRUG: Zinc sulfate|DRUG: Statins (Cardiovascular Agents)|DRUG: Hydroxy Urea|DRUG: Folic Acid Supplementation|DRUG: Morphine Sulfate|PROCEDURE: blood transfusion session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of an HIV-adapted IMCI Training and Supervision Programme for Community Health Workers
Status: COMPLETED
Conditions: Prevention of Mother-to-child Transmission of HIV|Antenatal Health Care Utilization|Postnatal Health Care Utilization|Infant Feeding Practices
Interventions: BEHAVIORAL: Enhanced HIV and MCH training for CHW
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Esophagectomy:Three-field Versus Two-field Lymphadenectomy (ECTOP-2002)
Status: COMPLETED
Conditions: Esophageal Neoplasms
Interventions: PROCEDURE: Lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Transcatheter Ventricular Septal Defect Closure on Heart Rate Variability Parameters
Status: COMPLETED
Conditions: Ventricular Septal Defect|Closure; Interventricular Septum|Autonomic Nervous System Imbalance
Interventions: DIAGNOSTIC_TEST: 24 hours ambulatory Holter monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Veteran Peer Navigators to Promote Shared Decision Making for PSA Screening
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer
Interventions: BEHAVIORAL: Veteran Peer Decision Coaching Session for PSA Screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Assessment of Attentional and Executive Disorders in Multiple Sclerosis Using Techniques of Virtual Reality
Status: COMPLETED
Conditions: Relapsing-Remitting Multiple Sclerosis
Interventions: OTHER: Assessment of attentional functions by traditional tests|OTHER: Assessment of attentional functions by virtual reality tests|OTHER: Assessment of executive functions by traditional tests|OTHER: Assessment of executive functions by virtual reality test|OTHER: Evaluation of cognitive complaint, fatigue, anxiety and depression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase I/II Double-blind Safety and Efficacy Evaluation of Nowarta110 in Patients With Plantar Warts
Status: COMPLETED
Conditions: Plantar Warts
Interventions: DRUG: Nowarta110|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Related Lung Ventilation and Perfusion Injury
Status: UNKNOWN
Conditions: Covid-19|Asthma|Healthy
Interventions: OTHER: V/Q SPECT-CT|OTHER: St. George's Respiratory Questionnaire (SGRQ)|OTHER: mMRC (Modified Medical Research Council) Dyspnea Scale|OTHER: Six-minute walk test (6MWT)|OTHER: Spirometry|OTHER: Plethysmography & DLCO|OTHER: Airwave Oscillometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating a Pharmacokinetic Drug Interaction Between HGP0918 and HGP0816
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HGP0918|DRUG: HGP0816|DRUG: HGP0918 + HGP0816
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Gain In Clinical Attachment And Bone Levels After Treatment of Patients With Intra-bony Defects By Minimally Invasive Surgical Technique Versus Open Flap Debridement.
Status: UNKNOWN
Conditions: Minimally Invasive Surgical Technique|Open Flap Debridement|Microsurgery
Interventions: PROCEDURE: Minimal invasive surgical technique|PROCEDURE: Open Flap Debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intraventricular tPA Following Aneurysmal Subarachnoid Hemorrhage
Status: WITHDRAWN
Conditions: Subarachnoid Hemorrhage|Cerebral Vasospasm|Cerebral Aneurysm|Hydrocephalus
Interventions: DRUG: Tissue Plasminogen Activator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I Study of Safety and Immunogenicity of AMA1-C1Alhydrogel + CPG 7909 Vaccine for Malaria
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: AMA1-C1/Alhydrogel + CPG 7909 Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Effectiveness and Tolerance of Two Acne Treatments on Subjects With Mild to Moderate Acne.
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DEVICE: Acne Mask|DRUG: 2.5% Benzoyl Peroxide Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Role of the Serotonin 5-HT2A Receptor in LSD-induced Altered States of Consciousness (LDR-Study)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LSD|DRUG: LSD|DRUG: LSD|DRUG: LSD|DRUG: LSD|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Pemetrexed in Children With Recurrent Cancer
Status: COMPLETED
Conditions: Osteosarcoma|Medulloblastoma|Sarcoma, Ewing's|Neuroblastoma (Measurable Disease)|Neuroblastoma (Metaiodobenzylguanidine|Positive Evaluable)|Rhabdomyosarcoma|Ependymoma|Non-brainstem High-grade Glioma
Interventions: DRUG: pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of Perineal Ultrasound in Thr Delivery Room to Improve the Diagnosis of OASIS
Status: UNKNOWN
Conditions: Episiotomy
Interventions: DEVICE: perineal ultrasound|PROCEDURE: Clinical diagnosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase I Study Evaluating TXA127 in Low/Intermediate-1 Risk Myelodysplastic Syndrome and Thrombocytopenia
Status: TERMINATED
Conditions: Myelodysplastic Syndrome (MDS)
Interventions: DRUG: TXA127
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Outcomes for Single vs Double Pyloromyotomy for Gastroparesis Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Gastroparesis
Interventions: PROCEDURE: gastric per-oral endoscopic myotomy (G-POEM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modification of Alternative Reward Cue Reactivity and Cognitive Control Through Physical Activity in Human Tobacco Use Disorder
Status: COMPLETED
Conditions: Healthy|Tobacco Use Disorder
Interventions: BEHAVIORAL: Exercise training|BEHAVIORAL: Smoking cessation group program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improve Checkpoint-blockade Response in Advanced Urothelial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Urothelial Carcinoma
Interventions: DRUG: Tremelimumab|DRUG: Durvalumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AMG386 Comb w. Either Pegylated Liposomal Doxorubicin or Topotecan Subjects w. Advanced Recurrent Epithelial Ovarian CR
Status: COMPLETED
Conditions: Cancer|Carcinoma|Fallopian Tube Cancer|Gynecological Malignancies|Metastases|Oncology|Ovarian Cancer|Solid Tumors|Tumors
Interventions: DRUG: A1: AMG 386 10 mg/kg + Liposomal doxorubicin|DRUG: A3: AMG 386 15mg/kg + Liposomal doxorubicin|DRUG: B1: AMG 386 10 mg/kg + Topotecan|DRUG: B3: AMG 386 15mg/kg + Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Rituximab in Treating Patients With HIV-Associated Stage I, Stage II, Stage III, or Stage IV Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: AIDS-related Diffuse Large Cell Lymphoma|AIDS-related Immunoblastic Large Cell Lymphoma|AIDS-related Peripheral/Systemic Lymphoma|AIDS-related Small Noncleaved Cell Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: etoposide|DRUG: doxorubicin hydrochloride|DRUG: vincristine sulfate|DRUG: prednisone|DRUG: cyclophosphamide|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Neoantigen mRNA Vaccines in Patients With Resectable Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: PROCEDURE: Surgery|DRUG: Camrelizumab|BIOLOGICAL: SJ-Neo006|DRUG: Gemcitabine+Abraxane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omission of Intact Parathyroid Hormone Testing During Surgery in Treating Patients With Primary Hyperparathyroidism
Status: COMPLETED
Conditions: Parathyroid Gland Adenoma|Primary Hyperparathyroidism
Interventions: OTHER: Laboratory Biomarker Analysis|PROCEDURE: Parathyroidectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Spironolactone to Improve Apnea and Cardiovascular Markers in Obstructive Sleep Apnea Patients
Status: WITHDRAWN
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: Spironolactone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE