pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Knee Osteoarthritis Disabling Pain Program for the Brazilian Unified Health System
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: OTHER: Clinical treatment and Knee educational program|OTHER: Knee educational program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-inferiority Study to Compare the Efficacy and Safety of Mylan's Insulin Glargine With Lantus® in Type 2 Diabetes Mellitus Patients (INSTRIDE 2)
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Mylan's insulin glargine|DRUG: Lantus®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Radiotherapy for Malignant Lacrimal Sac Tumors
Status: RECRUITING
Conditions: Malignant Tumor of Lacrimal Drainage Structure
Interventions: OTHER: Neoadjuvant Radiotherapy/Chemoradiotherapy Followed by Surgery|OTHER: Surgery Followed by Adjuvant Radiotherapy/Chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: tSCS + EksoGT in SCI Patients
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injury
Interventions: DEVICE: RGT+ tSCS + conventional physiotherap|DEVICE: RGT+ conventional physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation and Evaluation of Improved Access to Medical Imaging for Geriatric Patients of The Royal Ottawa Hospital
Status: NOT_YET_RECRUITING
Conditions: Dementia|Cognitive Impairment|Dementia With Lewy Bodies
Interventions: DIAGNOSTIC_TEST: [18F]FDG-PET Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Management of Pain in Lumbar Arthrodesis
Status: RECRUITING
Conditions: Pain, Postoperative
Interventions: DRUG: Ketamine|DRUG: Dexamethasone|DRUG: Physiologic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Pharmacokinetics, Safety, and Antiviral Activity of the Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (E/C/F/TAF) Single Tablet Regimen (STR) in HIV-1 Infected Antiretroviral Treatment-Naive Adolescents and Virologically Suppressed Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Acquired Immune Deficiency Syndrome (AIDS)|HIV Infections
Interventions: DRUG: E/C/F/TAF|DRUG: E/C/F/TAF (Low Dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Continuous Non-invasive All Vital Signs Monitoring Devices With Invasive Gold Standard for Children
Status: UNKNOWN
Conditions: Vital Signs|Blood Pressure|Hypertension|Oxygen Saturation|Children|Neonatal|Intensive Care Unit
Interventions: DEVICE: Non-invasive monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Text-based Intervention in Improving Adherence to Hormone Therapy in Patients With Stage I-III Hormone Receptor Positive Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Estrogen Receptor Positive Tumor|Progesterone Receptor Positive Tumor|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8
Interventions: BEHAVIORAL: Focus Group|OTHER: Text Message|OTHER: Best Practice|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Tolerability and Symptomatic Efficacy of the ROCK-Inhibitor Fasudil in Patients With Parkinson's Disease
Status: RECRUITING
Conditions: Idiopathic Parkinson´s Disease
Interventions: DRUG: Fasudil hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Studies of AQ-13, a Candidate Aminoquinoline Antimalarial, in Comparison With Chloroquine
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: AQ-13|DRUG: Chloroquine (CQ) Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Coping Skills Training (CST) for Children With Chronic Health Conditions
Status: COMPLETED
Conditions: Rheumatologic Conditions (JRA,Lupus)|Epilepsy|Spina Bifida|Asthma
Interventions: BEHAVIORAL: Coping Skills Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Study of Siltuximab (Anti- IL 6 Monoclonal Antibody) in Patients With High-risk Smoldering Multiple Myeloma
Status: COMPLETED
Conditions: High-risk Smoldering Multiple Myeloma
Interventions: DRUG: Siltuximab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BEYO Project to Promote Sense of Coherence and Self-care of Elderly People With Type 2 Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Sense of Coherence|Self Care|Strengths-based Intervention
Interventions: BEHAVIORAL: Be the Expert for Your Own (BEYO)|OTHER: Routine health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacological Treatment of Generalized Anxiety Disorder in the Elderly
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: DRUG: sertraline 50 mg daily|DRUG: sertraline 100 mg daily|DRUG: Placebo 50 or 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adaptive COVID-19 Treatment Trial 3 (ACTT-3)
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Interferon beta-1a|OTHER: Placebo|DRUG: Remdesivir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-CD33 CAR NK Cells in the Treatment of Relapsed/Refractory Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Leukemia, Myeloid, Acute
Interventions: BIOLOGICAL: anti-CD33 CAR NK cells|DRUG: Fludarabine|DRUG: Cytoxan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cross-Over Study to Compare the Pharmacokinetics and Pharmacodynamics of LIB003 Process 1 and Process 2 Drug Product
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: lerodalcibep
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Combined With Tislelizumab as Bladder Sparing Option for Patients With Muscle Invasive Bladder Cancer
Status: UNKNOWN
Conditions: Muscle-Invasive Bladder Carcinoma
Interventions: DRUG: Tislelizumab|DRUG: Cisplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treating Civilian Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation (ciTBI-HDtDCS)
Status: RECRUITING
Conditions: Traumatic Brain Injury|Word Finding Difficulty|Acquired Brain Injury|Cognitive Change
Interventions: DEVICE: Active Transcranial direct current stimulation|DEVICE: Sham Transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Long-term Safety of Lenvatinib Monotherapy, a Lenvatinib Combination Regimen, or a Comparator Treatment Arm to Cancer Participants in Eisai Sponsored Lenvatinib Trials
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: E7080|DRUG: Comparator Drug|DRUG: Comparator Drug: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY900014 Formulations in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: LY900014|BIOLOGICAL: Insulin Lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of a Mobile Application RA Joint Protection and Activity Self-management Program
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: BEHAVIORAL: Mobile application RA joint protection and activity self-management program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dietary Fiber During Radiotherapy - a Placebo-controlled Randomized Trial
Status: RECRUITING
Conditions: Malignant Neoplasm|Malignant Neoplasm of Rectum|Malignant Neoplasm of Anus|Malignant Neoplasm of Urinary Bladder|Malignant Neoplasm of Cervix|Malignant Neoplasm of Ovary|Malignant Neoplasm of Prostate|Malignant Neoplasm of Large Intestine|Malignant Neoplasm of Colon|Gynecologic Cancer
Interventions: BIOLOGICAL: Capsules containing either dietary fiber or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sirolimus, Cyclosporine, and Mycophenolate Mofetil in Preventing Graft-versus-Host Disease in Treating Patients With Blood Cancer Undergoing Donor Peripheral Blood Stem Cell Transplant
Status: COMPLETED
Conditions: Adult Acute Lymphoblastic Leukemia|Adult Acute Myeloid Leukemia|Adult Diffuse Large B-Cell Lymphoma|Adult Myelodysplastic Syndrome|Adult Non-Hodgkin Lymphoma|Aggressive Non-Hodgkin Lymphoma|Childhood Acute Lymphoblastic Leukemia|Childhood Acute Myeloid Leukemia|Childhood Diffuse Large B-Cell Lymphoma|Childhood Myelodysplastic Syndrome|Childhood Non-Hodgkin Lymphoma|Chronic Lymphocytic Leukemia|Chronic Lymphocytic Leukemia in Remission|Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Hematopoietic and Lymphoid Cell Neoplasm|Mantle Cell Lymphoma|Plasma Cell Myeloma|Prolymphocytic Leukemia|Recurrent Chronic Lymphocytic Leukemia|Refractory Chronic Lymphocytic Leukemia|T-Cell Prolymphocytic Leukemia|Waldenstrom Macroglobulinemia|Recurrent Diffuse Large B-Cell Lymphoma|Recurrent Hodgkin Lymphoma
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Cyclosporine|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|DRUG: Mycophenolate Mofetil|PROCEDURE: Peripheral Blood Stem Cell Transplantation|DRUG: Sirolimus|RADIATION: Total-Body Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oral Azacitidine (CC-486) Compared to Investigator's Choice Therapy in Patients With Relapsed or Refractory Angioimmunoblastic T Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma, T-Cell
Interventions: DRUG: Azacitidine|DRUG: Romidepsin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SQUED™ Series 28.1 Home-use and Treatment of Autowave Reverberator of Autism
Status: RECRUITING
Conditions: Autistic Disorder|Autism Spectrum Disorder|Child Development Disorders, Pervasive|Neurodevelopmental Disorders|Mental Disorders|Asperger's Syndrome|Neurobehavioral Manifestations|Nervous System Diseases
Interventions: DEVICE: SQUED™ series 28.1 home-use
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mindfulness-Based Stress Reduction for Adults With Low-Risk Chest Pain Associated With Anxiety
Status: COMPLETED
Conditions: Chest Pain|Anxiety|Mindfulness
Interventions: BEHAVIORAL: MBSR Referral|OTHER: Usual Care Referral
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of NMES on Bowel Management in People With Chronic SCI
Status: RECRUITING
Conditions: Electric Stimulation Therapy|Bowel Dysfunction|Spinal Cord Injuries|Defecation Disorder
Interventions: OTHER: Neuromuscular electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketamine Infusion vs Dexmedetomidine Infusion in Obese Patients Undergoing Bariatric Surgery
Status: UNKNOWN
Conditions: Morbid Obesity|Surgery
Interventions: DRUG: Ketamine|DRUG: Dexmedetomidine|DRUG: Normal Saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dual Antiplatelet Therapy Tailored on the Extent of Platelet Inhibition
Status: UNKNOWN
Conditions: Unstable Angina|NSTEMI
Interventions: DRUG: comparison of different dosage of clopidogrel|DRUG: doubled therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Bevacizumab (Avastin) in Women With HER2 Negative Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Docetaxel|DRUG: Placebo to bevacizumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: UARK 2014-21 A Phase II Trial of Oncolytic Virotherapy by Systemic Administration of Edmonston Strain of Measles Virus
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: MV-NIS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of HR021618 in Postsurgical Pain Management
Status: UNKNOWN
Conditions: Postsurgical Pain Management
Interventions: DRUG: HR021618|DRUG: HR021618|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Immunogenicity of VAL-181388 in Healthy Participants
Status: COMPLETED
Conditions: Chikungunya Virus
Interventions: BIOLOGICAL: VAL-181388|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Role of Vitamin D in Reducing the Relapse Rate in Patients With Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Bermekimab in Patients With Hidradenitis Suppurativa
Status: COMPLETED
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: Bermekimab Monoclonal Antibody 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Proprioceptive Stimulation of the Upper Limbs in Stroke Patients
Status: COMPLETED
Conditions: Stroke|Motor Disorders|Upper Extremity Paresis|Muscle Weakness|Vibration; Exposure
Interventions: DEVICE: FPS group|OTHER: Conventional therapy group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PROMISE I Early Feasibility Trial of the LimFlow Stent Graft System
Status: COMPLETED
Conditions: Critical Limb Ischemia|Chronic Limb-Threatening Ischemia
Interventions: DEVICE: LimFlow System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Smoking Cessation in the Community Via QTW 2015
Status: COMPLETED
Conditions: Smoking Cessation Intervention
Interventions: BEHAVIORAL: AWARD and brief leaflet/ Referral leaflet and active referral/ Smoking cessation booklet and general advices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Irreversible Electroporation(IRE) For Unresectable Laryngeal Neoplasms
Status: COMPLETED
Conditions: Laryngeal Neoplasms
Interventions: PROCEDURE: Irreversible electroporation (IRE)|DEVICE: NanoKnife
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Lamotrigine 25 mg Chewable Tablets of Dr.Reddy's Under Fed Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lamotrigine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glucagon-Like Peptide-1 Receptor Agonist in ADPKD
Status: NOT_YET_RECRUITING
Conditions: Autosomal Dominant Polycystic Kidney|Obesity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intramuscular and Intravenous VIR-7831 (Sotrovimab) for Mild/Moderate COVID-19.
Status: TERMINATED
Conditions: Covid19
Interventions: BIOLOGICAL: sotrovimab|BIOLOGICAL: sotrovimab|BIOLOGICAL: sotrovimab|BIOLOGICAL: sotrovimab|BIOLOGICAL: Sotrovimab|BIOLOGICAL: Sotrovimab|BIOLOGICAL: Sotrovimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Find How Safe and Effective GAMMAPLEX® is in Subjects With Chronic Idiopathic Thrombocytopenic Purpura (ITP)
Status: COMPLETED
Conditions: Chronic Idiopathic Thrombocytopenic Purpura
Interventions: BIOLOGICAL: Gammaplex, intravenous immunoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Emotional Dysregulation in Para-suicidal Behavior
Status: RECRUITING
Conditions: Self Harm|Suicide, Attempted|Emotional Instability|Borderline Personality Disorder
Interventions: BEHAVIORAL: Psychotherapy|OTHER: Pre-intervention testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mirtazapine for Sleep Disorders in Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer's Disease|Sleep Disorders
Interventions: DRUG: Mirtazapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Evaluation of the Efficacy of a Fasting Mimicking Diet Added to Functional Therapy for Depression
Status: COMPLETED
Conditions: Depression
Interventions: DIETARY_SUPPLEMENT: Fasting Mimicking Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cuff(SZ): The Cuff Size Blood Pressure Measurement Trial
Status: COMPLETED
Conditions: Hypertension|Blood Pressure|Cardiovascular Diseases|Cardiovascular Risk Factor
Interventions: OTHER: Order of cuff sizes during blood pressure measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Multicenter Study of Avapritinib Efficacy and Safety of Metastatic or Unresectable Gastrointestinal Stromal Tumors
Status: UNKNOWN
Conditions: Gastrointestinal Stromal Tumors|Unresectable Solid Tumor|Recurrent Metastatic Malignant Neoplasm
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Extension Study to Assess Effects of Non-interrupted Versus Interrupted and Long Term Treatment of Two Dose Regimes of Secukinumab in Subjects With Hidradenitis Suppurativa
Status: ACTIVE_NOT_RECRUITING
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: secukinumab|DRUG: secukinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study With Gemcitabine, Cisplatin, and LY293111 in Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Gemcitabine|DRUG: LY293111|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Molecular Signatures Associated With Response to ICS Treatment in Patients With COPD Stratified by Eosinophil Levels
Status: NOT_YET_RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Fall Prevention by Alfacalcidol and Training
Status: WITHDRAWN
Conditions: Accidental Falls|Chronic Renal Insufficiency|Aged
Interventions: DRUG: Alfacalcidol|BEHAVIORAL: Balance, gait and strength training|BEHAVIORAL: Patient education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase IIA Trial to Evaluate the Safety and Immunogenicity of a DNA HIV-1 Vaccine Followed by an MVA HIV-1 Vaccine in HIV-uninfected Volunteers
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: DNA.HIVA|BIOLOGICAL: MVA.HIVA|BIOLOGICAL: MVA.HIVA|BIOLOGICAL: MVA.HIVA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Working Memory Training to Decrease Rumination in Depressed and Anxious Individuals
Status: COMPLETED
Conditions: Major Depression|Anxiety Disorder
Interventions: BEHAVIORAL: Working memory training|BEHAVIORAL: Placebo training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Could a Time-restricted Diet Compete With a Calorie-restricted 6-meal Diet?
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: BEHAVIORAL: 16:8 Time-Restricted Intermittent Fasting Group|BEHAVIORAL: Energy-Restricted Six-Meal Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Taste Disorders and Their Relation to BMI, FFQ, and EORTC QLQ-BR23 in Breast Cancer Patients During Chemotherapy.
Status: COMPLETED
Conditions: Breast Cancer|Taste Disorders|Dysgeusia|Ageusia|Quality of Life
Interventions: OTHER: Taste disorder´s test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lamictal TM, Haloperidol Decanoate in Schizophrenia
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: Lamictal TM|DRUG: Haloperidol Decanoate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of a Toothpaste Containing Stannous Fluoride as Compared to Colgate Fluoride Toothpaste
Status: COMPLETED
Conditions: Gingivitis
Interventions: DRUG: Colgate Total SF|DRUG: Colgate Cavity Protection toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Larval Debridement Therapy Versus Sharp Debridement to Remove Biofilm
Status: COMPLETED
Conditions: Lower Extremity or Diabetic Foot Ulcers|Bacterial Infection
Interventions: DEVICE: Larval Debridement Therapy|PROCEDURE: Bedside Sharp Debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Combination of Radiotherapy，Surufatinib and Sintilimab in High-Risk Localized Soft Tissue Sarcoma
Status: RECRUITING
Conditions: High-Risk Localized Soft Tissue Sarcoma
Interventions: DRUG: Surufatinib|DRUG: Sintilimab|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Levodopa in Angelman Syndrome
Status: COMPLETED
Conditions: Angelman Syndrome
Interventions: DRUG: Levodopa|DRUG: Placebo Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of Naftopidil in Male Patients With Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia
Interventions: DRUG: Naftopidil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vandetanib Gemcitabine Or Placebo Plus Gemcitabine Or Vandetanib Monotherapy In Advanced Biliary Tract Cancer
Status: COMPLETED
Conditions: Biliary Tract Cancer|Gallbladder Cancer|Cancer Of The Extrahepatic Bile Duct|Ampullary Carcinoma
Interventions: DRUG: ZD6474, Vandetanib|DRUG: ZD6474, Vandetanib|DRUG: Gemcitabine|DRUG: Placebo matching ZD6474
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PAV-trial: Plerixafor and Chemotherapy With Vinorelbine for Stem Cell Mobilization in Patients With Myeloma
Status: COMPLETED
Conditions: Myeloma
Interventions: DRUG: Vinorelbine, G-CSF, & Plerixafor|DRUG: Vinorelbine and Plerixafor|DRUG: G-CSF and Plerixafor|DRUG: Vinorelbine & Plerixafor on day when CD34 count is at least 15'000 CD34+ cells/ml of peripheral blood
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Epidemiological Study to Assess the Disease Burden of Respiratory Syncytial Virus Associated, Suspected Lower Respiratory Tract Infections in Newborns, From 0 to 2 Years of Age and Risk of Development of Wheeze and Asthma From 0 to 6 Years of Age
Status: COMPLETED
Conditions: Respiratory Syncytial Virus
Interventions: PROCEDURE: Nasal swab sampling|PROCEDURE: Blood sampling|OTHER: Diary cards
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pilot Study to Assess Adherence to a Novel Eating System in Men and Women With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: NES With Energy Restriction|BEHAVIORAL: NES Without Energy Restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: USG-Guided Infiltration Popliteal Artery Capsule Knee Block Versus Adductor Canal Block Application as Postoperative Analgesia
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Tramadol|DRUG: Morfin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of gpASIT+TM Subcutaneously Administered to Hay Fever Patients With or Without Immunoregulating Adjuvant
Status: COMPLETED
Conditions: Hay Fever
Interventions: BIOLOGICAL: gpASIT+TM|BIOLOGICAL: gpASIT+TM + adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of the Use of Probiotics on the Intestinal Microbiota of Patients With Gastric Cancer
Status: COMPLETED
Conditions: Gastric Adenocarcinoma|Gastric Cancer|Microbiome|Cytokines|Nutritional Status
Interventions: DIETARY_SUPPLEMENT: Formulation with probiotics|OTHER: Non-intervention for Clinical Outcomes -G5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparing Suprainguinal Fascia Iliaca Block With Erector Spinae Plane Block in Hip and Proximal Femur Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Femur Fracture|Regional Anesthesia
Interventions: PROCEDURE: Regional Block Comparison
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: A Study of the Effectiveness and Safety of Risperidone Versus Placebo in the Treatment of Manic Episodes Associated With Bipolar I Disorder
Status: COMPLETED
Conditions: Bipolar Disorders|Manic Episode
Interventions: DRUG: Risperidone, oral tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Step'n Out: A Multisite Trial of Collaborative Behavioral Management for Drug-Involved Parolees
Status: UNKNOWN
Conditions: Substance-Related Disorders
Interventions: BEHAVIORAL: Collaborative Behavioral Management|PROCEDURE: Integrated parole and outpatient addiction treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Safety and Immunogenicity Trial of UBI SynVac (HIV-1 MN Octameric V3 Peptide Vaccine)
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: rgp120/HIV-1MN Monovalent Octameric V3 Peptide Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Process Optimization of Preoperative Biliary Drainage in Patients With Malignant Obstructive Jaundice
Status: UNKNOWN
Conditions: Jaundice, Obstructive|Klatskin Tumor
Interventions: PROCEDURE: PTBD group|PROCEDURE: ENBD group|PROCEDURE: EBS group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Open Label Safety Study of DCI-1020 in Pediatric Cystic Fibrosis (CF) Patients
Status: WITHDRAWN
Conditions: Digestive System Diseases|Pancreatic Disease|Cystic Fibrosis|Exocrine Pancreatic Insufficiency
Interventions: DRUG: DCI 1020
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of DN-101 (Calcitriol) and Docetaxel in Subjects Previously Enrolled in Studies DN101-002 or DN101-004
Status: UNKNOWN
Conditions: Androgen Independent Prostate Cancer (AIPC)|Non Small Cell Lung Cancer (NSCLC)
Interventions: DRUG: DN-101 (calcitriol) - Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abilify in Bipolar Disorder for 24 Weeks Treatment Effectiveness
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Abilify(aripiprazole)|DRUG: Depakote (divalproate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Patient Position on the Success in Placing Triple-cuffed Double Lumen Endotracheal Tube
Status: UNKNOWN
Conditions: Lung Diseases
Interventions: DEVICE: Intubation using 3-cuffed double lumen endotracheal tube
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Continued Treatment Among Participants Who Have Responded to Peginterferon Alfa-2a (Pegasys®) or Recombinant Interferon Alfa-2a (Roferon-A®) in Prior Clinical Studies
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia|Malignant Melanoma|Renal Cell Carcinoma
Interventions: DRUG: Pegylated Interferon Alfa-2a|DRUG: Recombinant Interferon Alfa 2a
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of NST-4016 on QT/Corrected QT (QTc) Interval
Status: COMPLETED
Conditions: Dyslipidemias
Interventions: DRUG: NST-4016 600mg|DRUG: Placebo oral capsule|DRUG: Moxifloxacin 400mg|DRUG: NST-4016 2000mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Plerixafor in Acute Respiratory Distress Syndrome Related to COVID-19 (Phase IIb)
Status: WITHDRAWN
Conditions: COVID-19 Acute Respiratory Distress Syndrome|COVID-19
Interventions: DRUG: Plerixafor 20 MG/ML [Mozobil]|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Integrating Infant Feeding Counselling With Psychosocial Stimulation to Improve Child Growth and Development in Urban Slum of Bangladesh
Status: COMPLETED
Conditions: Infant Malnutrition|Cognitive Change
Interventions: BEHAVIORAL: Peer counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Dapagliflozin Versus Metformin in Polycystic Ovary Syndrome
Status: NOT_YET_RECRUITING
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Dapagliflozin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of ASP2408 After Multiple Dose Subcutaneous Injections in Patients With Rheumatoid Arthritis on Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Pharmacokinetics of ASP2408
Interventions: DRUG: ASP2408|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Phase II Study of Fludarabine and Mitoxantrone, Followed by GM-CSF(Granulocyte-macrophage Colony-stimulating Factor) and Rituximab
Status: TERMINATED
Conditions: Lymphoma
Interventions: DRUG: Mitoxantrone/Cyclophosphamide, Fludarabine, Rituximab and GM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Acute Effects of Chamomile Intake on Blood Coagulation Tests in Healthy Volunteers
Status: COMPLETED
Conditions: Coagulation Disorder
Interventions: DIETARY_SUPPLEMENT: Chamomile Tea|DIETARY_SUPPLEMENT: Chamomile Extract Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Therapy to Maintain Remission in Dilated Cardiomyopathy
Status: NOT_YET_RECRUITING
Conditions: Heart Failure|Cardiomyopathy, Dilated|Cardiomyopathies|Heart Diseases
Interventions: DRUG: Other
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Disitamab Vedotin(RC48) Combined With Penpulimab(AK105) for Neoadjuvant Treatment of HER2-low Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Disitamab Vedotin|DRUG: Penpulimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diaphragmatic Breathing Exercises on Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: BEHAVIORAL: pelvic floor muscle exercises|BEHAVIORAL: diaphragmatic breathing exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Phototherapy on Pruritus of Patients With Chronic Kidney Disease
Status: COMPLETED
Conditions: Uremic Pruritus
Interventions: DEVICE: Narrow band UVB phototherapy , long wave UVA phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment of DAILIES TOTAL1® (DT1) Multifocal
Status: COMPLETED
Conditions: Refractive Error
Interventions: DEVICE: Delefilcon A multifocal contact lenses|DEVICE: Habitual multifocal contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid in Nasal Mohs Reconstruction
Status: RECRUITING
Conditions: Postoperative Bleeding|Skin Cancer Face
Interventions: DRUG: Treatment (tranexamic acid and 1% lidocaine with 1:100,000 epinephrine)|DRUG: Control (1% lidocaine with 1:100,000 epinephrine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Text Messaging (SMS) Intervention to Improve Adherence to Stimulant Medication in Adults With ADHD in the Primary Care Setting
Status: UNKNOWN
Conditions: Attention Deficit/Hyperactivity Disorder
Interventions: OTHER: SMS Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Scandinavian Non-interventional Study of Adherence to RebiSmart Administered Rebif New Formulation (RNF) Treatment in Relapsing Remitting Multiple Sclerosis (RRMS) Subjects
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis (RRMS)
Interventions: DEVICE: RebiSmart
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Investigate Efficacy and Safety of Adalimumab in Japanese Subjects With Generalized Pustular Psoriasis (GPP)
Status: COMPLETED
Conditions: Generalized Pustular Psoriasis (GPP)|Adalimumab|Japanese
Interventions: DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing Benefits of NIRAF Detection for Identifying Parathyroid Glands During Total Thyroidectomy.
Status: COMPLETED
Conditions: Postoperative Hypoparathyroidism|Thyroid Neoplasms|Thyroid Cancer
Interventions: DEVICE: NIRAF Detection Technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Clinical Efficacy and Human Factors Validation Testing of the Erchonia EVRL for Providing Temporary Relief of Diabetic Peripheral Neuropathy Foot Pain
Status: RECRUITING
Conditions: Neuropathy, Diabetic|Neuropathy;Peripheral|Neuropathy, Painful
Interventions: DEVICE: Erchonia® EVRL™|DEVICE: Placebo Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Adjuvant Treatment for Depressed Patients Undergoing ECT
Status: UNKNOWN
Conditions: Depressive Disorder, Major
Interventions: DRUG: Dexmedetomidine Injection [Precedex]|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: L-Arginine Treatment for Severe Vascular Fetal Intrauterine Growth Restriction: a Randomized Double Bind Controlled Trial (L Arginine in IUGR)
Status: TERMINATED
Conditions: Intra Uterine Growth Retardation
Interventions: DRUG: L ARG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SAR650984, Pomalidomide and Dexamethasone in Combination in RRMM Patients
Status: COMPLETED
Conditions: Plasma Cell Myeloma
Interventions: DRUG: Isatuximab SAR650984|DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TIL and Anti-PD1 in Metastatic Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Toxicity, Drug|Adverse Drug Event|Effects of Immunotherapy
Interventions: DRUG: Nivolumab & Tumor Infiltrating Lymphocytes with/without Interferon-Alpha
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest of Pregabalin (Lyrica) on the Treatment of Reflex Earache in Head and Neck Cancer.
Status: TERMINATED
Conditions: Earache
Interventions: DRUG: Pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Eltrombopag Plus G-CSF on Human CD34+ Cell Mobilization in Multiple Myeloma Patients Undergoing ASCT
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Eltrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Study of Phototherapy for Hyperbilirubinemia
Status: COMPLETED
Conditions: Hyperbilirubinemia
Interventions: DEVICE: LED fiberoptic blanket phototherapy (BiliSoft blue LED fiberoptic blanket phototherapy)|DEVICE: Metal halide phototherapy (Spot PT metal halide phototherapy)|DEVICE: LED bank phototherapy (Natus neoBlue LED bank phototherapy)|DEVICE: Metal halide plus LED fiberoptic blanket phototherapy (BiliSoft and Spot PT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Sacubitril/Valsartan Compared to Valsartan on LV Remodelling in Asymptomatic LV Systolic Dysfunction After MI
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: sacubitril/valsartan|DRUG: Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparasion of Autogenic Inhibition and Reciprocal Inhibition Muscle Energy Techniques (METS) in Piriformis Syndrome
Status: RECRUITING
Conditions: Piriformis Syndrome
Interventions: PROCEDURE: Autogenic Inhibition Muscle Energy Technique|PROCEDURE: Reciprocal Inhibition Muscle Energy Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ferric Citrate for the Prevention of Renal Failure in Adults With Advanced Chronic Kidney Disease
Status: COMPLETED
Conditions: Anemia, Iron Deficiency|Hyperphosphatemia|Renal Insufficiency, Chronic|Renal Anemia|Disease Progression|Cardiovascular|Iron
Interventions: DRUG: Ferric Citrate 1 GM Oral Tablet [AURYXIA]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Viral Inception of Asthma: Prospective Study From Infancy to School-age
Status: UNKNOWN
Conditions: Asthma
Interventions: DRUG: prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multimodal Exploration of Patients With Multiple Sclerosis for an Early Detection of Subtle Progression
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DEVICE: Visual Evoked Potential (VEP)|DEVICE: Somatosensory evoked potential (SSEP)|DEVICE: Transcranial magnetic motor evoked potentials (TCmMEP)|DEVICE: Tesla Brain MRI|DIAGNOSTIC_TEST: Blood test - Neurofilament light chain (NfL)|DIAGNOSTIC_TEST: Blood test - EBV serology
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Testing GDC-0032 (Taselisib) as a Potential Targeted Treatment in Cancers With PIK3CA Genetic Changes (MATCH-Subprotocol I)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lymphoma|Advanced Malignant Solid Neoplasm|Hematopoietic and Lymphoid Cell Neoplasm|Refractory Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Multiple Myeloma
Interventions: DRUG: Taselisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Ephedrine|DRUG: Pioglitazone|DRUG: Caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT