pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase 3, Randomized, Placebo-Controlled, Double-Blinded Trial of the Combined Lysis of Thrombus With Ultrasound and Systemic Tissue Plasminogen Activator (tPA) for Emergent Revascularization in Acute Ischemic Stroke
Status: TERMINATED
Conditions: Acute Ischemic Stroke
Interventions: DEVICE: Transcranial ultrasound as an adjunctive therapy to tPA|DRUG: Standard of care tPA therapy for acute ischemic stroke
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Innovative Treatment for Cervical Precancer (UH3)
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia
Interventions: DEVICE: CO2 standard therapy|DEVICE: CryoPen|DEVICE: Thermocoagulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Deer Bone Extract NS on Improvement in Cognitive-Bio-Markers of Cognitive Functions
Status: COMPLETED
Conditions: Healthy Adults With Subjective Memory Complaints
Interventions: DIETARY_SUPPLEMENT: NS 550mg|DIETARY_SUPPLEMENT: NS 1100mg|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Double-blind Study to Evaluate the Safety and Efficacy of Antroquinonol in Mild-Moderate COVID-19 Hospitalized Patients
Status: COMPLETED
Conditions: Covid-19
Interventions: DRUG: Antroquinonol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Use of Milrinone After Congenital Heart Surgery in Infants
Status: UNKNOWN
Conditions: Low Cardiac Output Syndrome|Cardiac Surgical Procedures|Infant
Interventions: DRUG: Milrinone|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Postoperative Analgesic Efficacy of Caudal Block Versus Spinal Block With Levobupivacaine for Inguinal Hernia in Children
Status: COMPLETED
Conditions: Pain, Postoperative|Analgesia
Interventions: DRUG: Levobupivacaine|DRUG: Levobupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Endoscopic Variceal Ligation (EVL) Versus EVL Plus Non-selective B-blockers (NSBB) For Prevention of Variceal Rebleed and Non-bleed Related Complications in Patients With Advanced Cirrhosis
Status: WITHDRAWN
Conditions: Advanced Cirrhosis
Interventions: PROCEDURE: Endoscopic Variceal Ligation|DRUG: Non selective beta blocker|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effect of Two Different Bed Baths Applied to Patients on Mechanical Ventilation Support
Status: ENROLLING_BY_INVITATION
Conditions: The Effect of Two Different Bed Baths|Patients on Mechanical Ventilation Support
Interventions: PROCEDURE: Disposable Wipes for wiping baths|PROCEDURE: Traditional bed bath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Erlotinib Hydrochloride With or Without Carboplatin and Paclitaxel in Treating Patients With Stage III-IV Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Adenocarcinoma|Lung Adenosquamous Carcinoma|Malignant Pericardial Effusion|Malignant Pleural Effusion|Minimally Invasive Lung Adenocarcinoma|Stage IIIB Lung Non-Small Cell Cancer AJCC v7|Stage IV Lung Non-Small Cell Cancer AJCC v7
Interventions: DRUG: Carboplatin|DRUG: Erlotinib|DRUG: Erlotinib Hydrochloride|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thoracic Computed Tomography Scan for Diagnosis of Aspirated Foreign Bodies.
Status: COMPLETED
Conditions: Aspirated Foreign Body of Lower Respiratory Tract
Interventions: PROCEDURE: Thoracic CT Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: TOP: Recombinant Human Parathyroid Hormone (ALX1-11) on Fracture Incidence in Women With Postmenopausal Osteoporosis
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: placebo|DRUG: ALX1-11
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Remote Effects of Lower Limb Stretching
Status: COMPLETED
Conditions: Fascia|Randomized Controlled Trial|Stretching|Myofascial
Interventions: OTHER: Static Stretching lower limb|OTHER: Static stretching Cervical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Operating Room Time Length With the Use of Virtual Surgical Planning Versus Conventional Treatment of Mandible Fractures
Status: COMPLETED
Conditions: Mandibular Fractures
Interventions: DEVICE: Control group without use of VSP|DEVICE: Treatment Group with use of VSP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug Interaction Study of ACH-0145228
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ACH-0145228|DRUG: Midazolam|DRUG: Digoxin|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hyper-CVAD With Liposomal Vincristine in Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Rituximab|DRUG: Imatinib|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Mesna|DRUG: VSLI|DRUG: Solu-Medrol|DRUG: Methotrexate|DRUG: Ara-C|DRUG: G-CSF|DRUG: Pegfilgrastim|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Virtual Reality Treadmill-Based Gait Training on Gait and Balance Ability in Chronic Stroke Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Stroke|Hemiplegia
Interventions: DEVICE: Virtual Reality-Treadmill Training Group (VTT)|OTHER: Conventional Therapy Group (CT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hormone Receptor Positive Metastatic Breast Cancer (HR+ mBC) BIIB021 Plus Aromasin Schedule Finding
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: BIIB021|DRUG: BIIB021|DRUG: exemestane (Aromasin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Antibiotic Treatment for Hand Lacerations Involving Flexor and/or Extensor Tendon
Status: COMPLETED
Conditions: Hand Laceration|Tendon Involved|Clean Laceration|No Bone Involved
Interventions: DRUG: Antibiotic-Cefamezin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Imaging Quality Between Spectral Photon Counting Computed Tomography (SPCCT) and Dual Energy Computed Tomography (DECT)
Status: RECRUITING
Conditions: Diabetic Foot Ulcer|Coronary Artery Disease|Parenchymatous; Pneumonia|Kidney Stone|Inner Ear Disease|Brain Stroke|Joint Diseases|Diabetes|Adrenal Incidentaloma|Hyperaldosteronism|Macroadenoma|Interstitial Lung Disease|Intracranial Arteriovenous Malformations
Interventions: DEVICE: Spectral Photon Counting Computed Tomography (SPCCT)|DEVICE: DECT (Dual Energy CT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Anti-CD123 CAR-T Therapy in Patients With Refractory/ Relapsed CD123+ Acute Myeloid Leukemia.
Status: UNKNOWN
Conditions: CD123+ Acute Myeloid Leukemia
Interventions: BIOLOGICAL: Third-generation anti-CD123 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
Status: RECRUITING
Conditions: Brain Cancer|Breast Cancer|Bladder Cancer|Cervical Cancer|Colorectal Cancer|Endometrial Cancer|Esophageal Cancer|Stomach Cancer|Head and Neck Cancer|Hepatobiliary Cancer|Leukemia|Lung Cancer|Lymphoma|Multiple Myeloma|Ovarian Cancer|Pancreatic Cancer|Prostate Cancer|Renal Cancer|Sarcoma|Thyroid Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Efficacy of Indomethacin in Early Treatment of Acute Pancreatitis
Status: RECRUITING
Conditions: Acute Pancreatitis|Systemic Inflammatory Response Syndrome
Interventions: DRUG: Indometacin|OTHER: conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Motivation and Methylphenidate
Status: UNKNOWN
Conditions: Motivation|Apathy|Impulsive Behavior
Interventions: DRUG: Ritalin 10Mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Customizable Respiratory Exercise Device in Individuals Who Have Undergone Cardiac Surgery
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease
Interventions: OTHER: Incentive spirometer|OTHER: Individualized respiratory training group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postexposure Prophylaxis With Single Dose Doxycycline for the Prevention of Tick-borne Relapsing Fever
Status: NOT_YET_RECRUITING
Conditions: Relapsing Fever, Tick-Borne
Interventions: DRUG: administration of single dose of doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Dose Finding Study of DAOIB Added to tDCS for AD
Status: SUSPENDED
Conditions: Transcranial Direct Current Stimulation|Dementia
Interventions: DRUG: DAOIB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LTP+CaCBT for Treating Postnatal Depression and Improving Child Wellbeing in Jos Nigeria
Status: UNKNOWN
Conditions: Postnatal Depression
Interventions: BEHAVIORAL: LTP|BEHAVIORAL: CaCBT|DRUG: TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Nasal Versus Oral Midazolam Sedation in Routine Pediatric Dental Care
Status: COMPLETED
Conditions: Conscious Sedation
Interventions: DRUG: oral midazolam|DRUG: nasal midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms
Status: RECRUITING
Conditions: Bipolar Disorder|Major Depressive Disorder|Mood Disorders|Suicide|Suicidal Ideation
Interventions: BEHAVIORAL: BE-SMART-DR|BEHAVIORAL: psychoeducational control comparator condition (CC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Continuous Versus Cyclic Daytime Enteral Nutrition on Circadian Rhythms in Critical Illness
Status: RECRUITING
Conditions: Critical Illness|Intensive Care Unit|Circadian Rhythm|Sleep|Enteral Nutrition
Interventions: OTHER: Cyclic daytime enteral nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Radiation Therapy Plus Bone Marrow Transplantation in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: dexamethasone|DRUG: etoposide|PROCEDURE: autologous bone marrow transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Role of Pilates, Plyometrics, and Their Combination for Children With Unilateral Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: Pilates-based Core Strengthening Exercises|OTHER: Plyometric-based Muscle Loading Exercises|OTHER: Combined Pilates and Plyometrics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Udenafil on Exercise Capacity in Severe Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: COMPLETED
Conditions: Dyspnea|Chronic Obstructive Pulmonary Disease|Pulmonary Hypertension
Interventions: DRUG: Udenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regorafenib Alone or in Combined With Transcatheter Arterial ChEmoembolization in Treatment of Advanced Hepatocellular Carcinoma After First Line Targeted Therapy
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Transcatheter Arterial ChEmoembolization|Regorafenib
Interventions: PROCEDURE: TACE|DRUG: Regorafenib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: L-citrulline Supplementation During Sepsis
Status: UNKNOWN
Conditions: Sepsis|Multiple Organ Failure
Interventions: DIETARY_SUPPLEMENT: L-citrulline supplementation|DIETARY_SUPPLEMENT: L-alanine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Notify 2: An Evaluation of the Impact of Notification of Incidental Coronary Artery Calcium on Statin Rates
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: OTHER: Notification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study Evaluating The Coadministration of Begacestat And Donepezil
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Donepezil plus placebo|DRUG: Donepezil|DRUG: Begacestat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Azacitidine in Combination With Venetoclax Treatment for MRD Positive Post Allo-HSCT AML/MDS Patients
Status: RECRUITING
Conditions: Hematologic Malignancy|Stem Cell Transplant Complications
Interventions: DRUG: Azacitidine in Combination With Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: INvestigation on Routine Follow-up in CONgestive HearT FAilure Patients With Remotely Monitored Implanted Cardioverter Defibrillators (ICD) SysTems
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: Quarterly remote follow ups and remote monitoring|OTHER: Quarterly remote follow ups + additional phone calls and remote monitoring|OTHER: Quarterly in clinic follow ups and remote monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACE2 Chewing Gum on SARS-CoV-2 Viral Load (COVID 19)
Status: NOT_YET_RECRUITING
Conditions: SARS-CoV-2
Interventions: DRUG: ACE2 Chewing Gum|OTHER: Placebo Chewing Gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Ropivacaine With Clonidine For Pediatric Rectus Sheath Blocks- The Magic Combination
Status: TERMINATED
Conditions: Postoperative Pain
Interventions: DRUG: Clonidine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Web Based Genital Hygiene Education Provided to Orthopedically Disabled Women
Status: COMPLETED
Conditions: Disability Physical|Genital Infection
Interventions: OTHER: web based education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Seroprevalence Study of Hepatitis A, Varicella-Zoster, Cytomegalovirus, Herpes Simplex and Bordetella Pertussis
Status: COMPLETED
Conditions: Viral Hepatitis Vaccines|Hepatitis A|Cytomegalovirus|Varicella-Zoster Virus|Bordetella Pertussis Infection|Herpes Simplex (1 and 2)
Interventions: OTHER: Serum sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Tolerability and Immunogenicity of INO-4800 Followed by Electroporation in Healthy Volunteers for COVID19
Status: COMPLETED
Conditions: Coronavirus Infection|SARS-CoV 2
Interventions: BIOLOGICAL: INO-4800|DEVICE: CELLECTRA® 2000|OTHER: Saline-sodium citrate (SSC) buffer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Of Oral PF-01913539 In Patients With Mild To Moderate Alzheimer's Disease
Status: WITHDRAWN
Conditions: Alzheimer's Disease|Dementia|Dimebon|Investigational Drug
Interventions: DRUG: PF-01913539 5 mg|DRUG: PF-01913539 5 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Nutrition Intervention for Arthritis -4 (WCCR-ARTH4)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: OTHER: Plant-based diet|DIETARY_SUPPLEMENT: Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Single Stage Versus Multiple Staged Repair of Nasal & Alveolar Deformities in Patients With Cleft Lip and Palate
Status: RECRUITING
Conditions: Cleft Lip and Palate|Rhinoplasty
Interventions: PROCEDURE: Rhinoplasty with or without cleft alveolus repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy Study of Adjuvant Treatment With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab in Participants With High-Risk Melanoma (KEYNOTE-942)
Status: RECRUITING
Conditions: Melanoma
Interventions: DRUG: mRNA-4157|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Daratumumab in Combination With Dexamethasone in Resistant or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Daratumumab|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Four-Arm Study Comparing Combination Nucleoside, Alternating Nucleoside, and Triple-Drug Therapy for the Treatment of Advanced HIV Disease (CD4 <= 50/mm3)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Nevirapine|DRUG: Zidovudine|DRUG: Zalcitabine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Aesthetic Surgical Wound Closure by a Single Layer in Comparison With Traditional Multi-layer Closure
Status: COMPLETED
Conditions: Surgical Wound Closure Technique
Interventions: PROCEDURE: surgical wound suturing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety, Tolerability, and Blood Concentration of PMC-309
Status: NOT_YET_RECRUITING
Conditions: Advanced or Metastatic Solid Tumors
Interventions: DRUG: PMC-309 monotherapy|DRUG: PMC-309 Dose Escalation in Combination with Pembrolizumab|DRUG: PMC-309 Dose Expansion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study Evaluating Strategies of Lung Surveillance of Patients Operated of High Grade Soft Tissue Sarcoma
Status: TERMINATED
Conditions: Soft Tissue Sarcoma|Lung Metastasis
Interventions: PROCEDURE: chest radiography|PROCEDURE: chest CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Lifestyle Intervention in the Biological Aging in Prediabetes
Status: NOT_YET_RECRUITING
Conditions: PreDiabetes|Marker; Structural
Interventions: OTHER: Providing nutritional counselling|OTHER: counseling on physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Oral Albendazole in the Treatment of Severe Acute Malnutrition
Status: WITHDRAWN
Conditions: Kwashiorkor|Marasmus
Interventions: DRUG: Placebo|DRUG: Albendazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness-based Smoking Cessation Enhanced With Mobile Technology
Status: ACTIVE_NOT_RECRUITING
Conditions: Cigarette Smoking
Interventions: BEHAVIORAL: Mindfulness-Based Addiction Treatment|DRUG: Nicotine Replacement Therapy|BEHAVIORAL: Self-help materials|BEHAVIORAL: iQuit Mindfully
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Expression of Angiogenic Biomarkers During Healing of Intra-Oral Soft Tissue Engineered Grafts
Status: COMPLETED
Conditions: Gingival Recession
Interventions: BIOLOGICAL: CelTx™|PROCEDURE: Free Gingival Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing rTMS Treatment Strategies for Pain in Opiate Dependence
Status: COMPLETED
Conditions: Pain|Chronic Pain|Opioid Dependence|Opioid Use
Interventions: DEVICE: Real iTBS|DEVICE: Sham iTBS|DEVICE: Real cTBS|DEVICE: Sham cTBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Weekly Docetaxel/Irinotecan for Non-resectable Gastric Cancers After Cisplatin Plus 5-FU/Leucovorin
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: Docetaxel-Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Adrenocorticotropic Hormone on Vascular Endothelial Growth Factor Release in Children Study
Status: COMPLETED
Conditions: Adrenal Insufficiency|Osteopenia, Osteoporosis|Steroid Suppression of ACTH Secretion
Interventions: DRUG: Low Dose Cosyntropin (ACTH) stimulation test|DRUG: High Dose Cosyntropin (ACTH) stimulation test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Preventing Sexual Transmission of HIV With Anti-HIV Drugs
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Atazanavir|DRUG: Didanosine|DRUG: Efavirenz|DRUG: Emtricitabine/Tenofovir disoproxil fumarate|DRUG: Lamivudine|DRUG: Lopinavir/Ritonavir|DRUG: Nevirapine|DRUG: Stavudine|DRUG: Tenofovir disoproxil fumarate|DRUG: Zidovudine/Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Tranexamic Acid on Intraoperative and Post-Operative Bleeding in Functional Endoscopic Sinus Surgery
Status: WITHDRAWN
Conditions: Chronic Sinusitis
Interventions: DRUG: Tranexamic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Brief MI Intervention in the ED to Increase Child Passenger Restraint Use
Status: COMPLETED
Conditions: Child Restraint Systems|Seat Belts
Interventions: BEHAVIORAL: Motivational Interviewing|BEHAVIORAL: Tailored brochure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A PROpensity Score Matching Analysis on ENDovascular vs Open Thoraco-Abdominal Aortic Aneurysm Repair (PRO-ENDO TAAA Study)
Status: COMPLETED
Conditions: Thoracoabdominal Aortic Aneurysms
Interventions: PROCEDURE: Surgical repair|PROCEDURE: Endovascular repair
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CHOICES3: Sickle Cell Disease Parenting CHOICES
Status: RECRUITING
Conditions: Sickle Cell Disease|Sickle Cell Trait
Interventions: OTHER: CHOICES|OTHER: eBook
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Laxation and Satiety Response of Novel Dietary Fibers
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Glucose polymer fiber|DIETARY_SUPPLEMENT: Fiber made from corn starch|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: 68Ga-PSFA PET Imaging in Patients With PSMA/FAP Positive Disease
Status: RECRUITING
Conditions: PSMA|FAP|Positron-Emission Tomography
Interventions: DRUG: 68Ga-PSFA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of PET Scans With the Radioactive Tracer 18F-BMS-986229 in Patients With Esophageal, Stomach, or Gastroesophageal Junction Cancer
Status: COMPLETED
Conditions: Esophagogastric Cancer|Esophagus Cancer|Esophageal Cancer|Gastric Cancer|Gastric Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma|Gastroesophageal Junction Squamous Cell Carcinoma
Interventions: DRUG: 18F-BMS-986229 Injection|DRUG: IV 18F-BMS-986229|DIAGNOSTIC_TEST: PET/CT Scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mapping Aspects of Psychotherapy in Dialectical Behavior Therapy
Status: COMPLETED
Conditions: Borderline Personality Disorder
Interventions: BEHAVIORAL: Dialectical behavior therapy - emotion regulation skills training|BEHAVIORAL: Dialectical behavior therapy - interpersonal effectiveness skills training|BEHAVIORAL: Interpersonal psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Longitudinal Evaluation of Antibody Kinetics of Vaccinated Patients With Non-mandatory Vaccine Following Administration of a Non-public Marketed Vaccine in the General Population, Real-life Study
Status: NOT_YET_RECRUITING
Conditions: Vaccination Reaction
Interventions: BIOLOGICAL: Blood collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase I Low Dose WART in Combination With Weekly Paclitaxel for Platinum Resistant Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: DRUG: Paclitaxel|RADIATION: LDWART (Low Dose Whole Abdominal Radiation Therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence of DRP and DME Among Type 1 Diabetics Treated With Long-term Intensified Insulin Therapy
Status: COMPLETED
Conditions: Insulin-Dependent Diabetes Mellitus 1
Interventions: OTHER: cross-sectional observation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Tolerability Study of LBS-008 in Healthy Adult Subjects After Single and Multiple Doses
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: LBS-008|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Effects of Omeprazole and Rifampin on the Pharmacokinetics of VX-548 in Healthy Participants
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: VX-548|DRUG: Omeprazole|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Talocrural Joint Manipulation in Stroke
Status: RECRUITING
Conditions: Stroke
Interventions: OTHER: Talocrural Joint Manipulation|OTHER: Placebo Talocrural Joint Manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Response Study of MDMA-assisted Psychotherapy in People With PTSD
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: Comparative-dose (40mg) MDMA|DRUG: Active Dose 2 (100 mg) MDMA|DRUG: Active Dose 1 (125 mg) MDMA|BEHAVIORAL: Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Delivery of Patient Education: A Case Study of Symptom Self-Management During Cancer Treatment
Status: RECRUITING
Conditions: Digital Education Interventions|Knowledge Types (Mechanistic Versus Procedural)
Interventions: BEHAVIORAL: Digital education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Individualized Therapies Selection for Patients With Metastatic Colorectal Carcinoma According to the Therapeutic
Status: COMPLETED
Conditions: Adenocarcinoma of Colon|Adenocarcinoma of Rectum|Metastatic Disease
Interventions: DRUG: Arm A chemotherapy|DRUG: arm B chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autonomic Determinants of POTS - Pilot1
Status: RECRUITING
Conditions: Postural Tachycardia Syndrome
Interventions: DRUG: Moxonidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Comparison of Five Treatments in Patients With Plantar Warts
Status: TERMINATED
Conditions: Plantar Warts
Interventions: DRUG: Salicylate ointment|DRUG: Imiquimod|DRUG: 5-Fluoro-Uracil|DRUG: Cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of CARdiac Abnormalities by Echocardiography and MRI in Malnourished Patients Suffering From Anorexia Nervosa
Status: UNKNOWN
Conditions: Anorexia Nervosa|Cardiac Anomaly
Interventions: DEVICE: gadolinium-enhanced cardiac MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Customized Medication Adherence Enhancement for Adults With Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: BEHAVIORAL: Psychoeducation module|BEHAVIORAL: Substance use module|BEHAVIORAL: Improved communication/rapport with provider module|BEHAVIORAL: Medication routines management module
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Choroidal Morphology Changes After Aflibercept Therapy in Pachychoroid Neovasculopathy
Status: NOT_YET_RECRUITING
Conditions: Pachychoroid Neovasculopathy
Interventions: DRUG: Three monthly injections of intravitreal aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Chair Yoga on Elders With Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis (OA)
Interventions: BEHAVIORAL: Sit 'N' Fit Chair Yoga (SNFCY)|BEHAVIORAL: Health Education Program (HEP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate ENERGI-F703 GEL in Diabetic Foot Ulcer
Status: RECRUITING
Conditions: Diabetic Foot Ulcer|Foot Ulcer|Diabetes Mellitus|Wound
Interventions: DRUG: ENERGI-F703 GEL|DRUG: ENERGI-F703 matched vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Increasing Breast, Cervical, and Colorectal Cancer Screening and HPV Vaccination Among Underserved Texans
Status: COMPLETED
Conditions: Cancer Prevention
Interventions: BEHAVIORAL: Cancer control navigation (CNN)|BEHAVIORAL: General referral (usual care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Research Study To See How Well An Eye Drop (SURF-200) Works, What Side Effects There Are, And To Compare It With Vehicle In Subjects With An Episodic Flare-Up of Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: 0.02% Betamethasone Sodium Phosphate|DRUG: 0.04% Betamethasone Sodium Phosphate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NoYA RAISE Trial II (Radiofrequency Ablation-Based Interatrial Shunt for Heart Failure)
Status: UNKNOWN
Conditions: Heart Failure
Interventions: DEVICE: NoYA™ Radiofrequency Interatrial Shunt System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 12-weeks Study to Evaluate Sulforaphane in Treatment of Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DIETARY_SUPPLEMENT: Sulforaphane|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Curcumin Pharmacokinetics
Status: COMPLETED
Conditions: Comparative Multidose Pharmacokinetics
Interventions: DRUG: curcumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Differential Effects of Zolpidem Versus Ramelteon in Burned Children
Status: COMPLETED
Conditions: Sleep|Burns
Interventions: DRUG: zolipidem|DRUG: ramelteon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physical Activity and Cognitive Behavioural Therapy in Panic Disorder and Agoraphobia
Status: COMPLETED
Conditions: Panic Disorder|Agoraphobia
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Novel Estrogen Receptor(ER) a36 Modifier Icaritin in Advanced Breast Cancer Patients
Status: UNKNOWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Icaritin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peginterferon Beta-1a (BIIB017) Autoinjector Pharmacokinetic Study in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy|Multiple Sclerosis
Interventions: DEVICE: BIIB017 (peginterferon beta-1a) Pre-filled syringe (PFS)|DEVICE: BIIB017 (peginterferon beta-1a) Autoinjector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Zinc Sulfate for Human Papillomavirus (HPV)
Status: TERMINATED
Conditions: Human Papilloma Virus
Interventions: DIETARY_SUPPLEMENT: Zinc Sulfate|OTHER: Placebo (Gelatin Tablet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Relationship Between Functional Movement and Respiratory Muscle Strength
Status: COMPLETED
Conditions: Functional Movement Quality|Respiratory Muscle Strength|Core Stability|Injury
Interventions: OTHER: Funcional movement screen|DIAGNOSTIC_TEST: Respiratory muscle strength
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Darunavir|DRUG: Ritonavir|DRUG: Dolutegravir|DRUG: Tenofovir alafenamide (TAF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plerixafor and Cemiplimab in Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: Cemiplimab|DRUG: Plerixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validity and Reliability of the Turkish Version of the Tele-Pulmonary Rehabilitation Acceptance Scale
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Disease|Telehealth|Pulmonary Rehabilitation
Interventions: OTHER: Turkish version of the Tele-Pulmonary Rehabilitation Acceptance Scale|OTHER: Scale Evaluation Form
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy & Safety of Dry Powder Ivy Extract (Syrup Prospan) Versus NAC Among COPD Patients
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Syrup Prospan|DRUG: N-Acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunotolerance in Endometrial Cancer and at the Maternal-fetal Interface: Immunological Profiling of the Tumor Microenvironment in Risk Stratification of Recurrence
Status: RECRUITING
Conditions: Endometrial Cancer
Interventions: DIAGNOSTIC_TEST: tissue samples (healthy and tumor taken from the same patient) and tissue samples (decidualized endometrium and trophoblast taken from it patient)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exparel v Dexamethasone in RCR
Status: ENROLLING_BY_INVITATION
Conditions: Rotator Cuff Tears|Postoperative Pain
Interventions: DRUG: Liposomal bupivacaine|DRUG: Bupivacaine Hcl 0.5% Inj|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Analgecine for Treatment of Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: Analgecine|DRUG: Neurotropin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of BAY43-9006 and Taxotere to Treat Patient With Prostatic Cancer
Status: COMPLETED
Conditions: Primary Disease|Prostate Cancer
Interventions: DRUG: sorafenib (200 or 400mg bid) and taxotere iv
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BETAEVAL Global - The New BETACONNECT Auto-injector : Adherence and EVALuation of Multiple Sclerosis Patients Treated With Betaferon
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing Remitting
Interventions: DRUG: Interferon beta-1b (Betaferon®, BAY 86-5046)|DEVICE: BETACONNECT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Real Time Amplitude Spectrum Area to Guide Defibrillation
Status: TERMINATED
Conditions: Out-Of-Hospital Cardiac Arrest|Ventricular Fibrillation
Interventions: DIAGNOSTIC_TEST: AMSA|PROCEDURE: Defibrillation|PROCEDURE: CPR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Risk Assessment For Kidney Transplantation - Utility of Computed Tomography Coronary Angiography in the Assessment of Patients Awaiting Kidney Transplantation
Status: RECRUITING
Conditions: Cardiovascular Diseases|Kidney Transplant; Complications
Interventions: RADIATION: Computed tomography coronary angiography (CTCA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bruton's Tyrosine Kinase Inhibitor Ibrutinib as Maintenance Treatment in Elderly Patients With Primary CNS Lymphoma
Status: UNKNOWN
Conditions: Central Nervous System Lymphoma
Interventions: DRUG: Imbruvica
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of LiRIS® in Females With Interstitial Cystitis/Bladder Pain Syndrome
Status: COMPLETED
Conditions: Cystitis, Interstitial|Painful Bladder Syndrome
Interventions: COMBINATION_PRODUCT: LiRIS®|COMBINATION_PRODUCT: LiRIS Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Urodynamic and Clinical Efficacy of Mirabegron for Neurogenic Bladder Patients
Status: TERMINATED
Conditions: Urinary Bladder, Neurogenic
Interventions: DRUG: Mirabegron|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Test of a Community-based Buprenorphine Treatment Intervention
Status: COMPLETED
Conditions: Opioid Dependence|Injection Drug Use
Interventions: BEHAVIORAL: Community-based buprenorphine treatment (CBBT) intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrosurgical Bipolar Systems Versus Conventional Electrocautery After SLNBx
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DEVICE: Electrosurgical bipolar system (LigaSure)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Safety, Efficacy, and Pharmacokinetic Study of 2',3'-Dideoxyinosine (ddI) Administered Twice Daily to Patients With AIDS or AIDS Related Complex
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety, Tolerability, and Pharmacokinetics of SPR720 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: SPR720 for SAD|DRUG: Placebo for SAD|DRUG: SPR720 for MAD|DRUG: Placebo for MAD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypofractionated Boost vs Conventionally Fractionated Boost for Localized High Risk Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: Conventionally Fractionated versus Hypofractionated Boost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inspiratory Muscle Strength Training to Improve Blood Pressure and Physiological Function
Status: COMPLETED
Conditions: Hypertension|Prehypertension|Aging
Interventions: OTHER: Inspiratory muscle strength training|OTHER: Sham training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Measuring Biting Force of Poly-amide Complete Dentures
Status: UNKNOWN
Conditions: Complete Edentulism
Interventions: OTHER: Poly-amide|OTHER: Poly-methyl methacrylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tsunami DRG High Frequency Stimulation Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Back Pain|Chronic Back and Leg Pain
Interventions: DEVICE: Spinal Cord Stimulator HF|DEVICE: Spinal Cord Stimulator Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT