pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Randomized Trial of a Liberal Versus a Restrictive Transfusion Strategy in Elderly Cardiac Surgery Patients
Status: COMPLETED
Conditions: Anemia|Coronary Artery Bypass Surgery
Interventions: PROCEDURE: Blood Transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PSMA-PET Guided Hypofractionated Salvage Prostate Bed Radiotherapy
Status: RECRUITING
Conditions: Prostate Cancer|Cancer Recurrence
Interventions: RADIATION: Conventional sEBRT|RADIATION: Hypofractionated sEBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The preDIlatation in tRanscathEter aortiC Valve implanTation Trial
Status: COMPLETED
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: balloon aortic valvuloplasty|DEVICE: Transcatheter Aortic Valve Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Albiglutide + Insulin Glargine Versus Insulin Lispro + Insulin Glargine Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Albiglutide|DRUG: Insulin Glargine and Insulin Lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studying Biomarkers in Tumor Tissue and Blood Samples From Patients Undergoing Chemotherapy and Radiation Therapy for Stage II or Stage III Rectal Cancer That Can Be Removed By Surgery
Status: WITHDRAWN
Conditions: Colorectal Cancer
Interventions: DRUG: systemic chemotherapy|GENETIC: RNA analysis|GENETIC: gene expression analysis|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|PROCEDURE: endoscopic biopsy|PROCEDURE: neoadjuvant therapy|PROCEDURE: sigmoidoscopy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Assess Safety and Efficacy of ADO09 Versus Insulin Aspart in Subjects With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: ADO09 formulation|DRUG: NovoRapid®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing After Total Knee Arthroplasty (TKA)
Status: NOT_YET_RECRUITING
Conditions: Knee Osteoarthritis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Conivaptan in Subjects With Mild & Moderate Liver Impairment Versus Subjects With Normal Liver Function
Status: COMPLETED
Conditions: Liver Disease|Hyponatremia
Interventions: DRUG: conivaptan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Serum Profile of Inflammatory Factors, Immune and Angiogenic in Temporal Lobe Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: OTHER: blood sampling for drug resistance biomarkers|DEVICE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of BBT Versus Diaphragmatic Breathing on Exercise Capacity and Quality of Life in Patients With COPD
Status: COMPLETED
Conditions: Breathing Technique
Interventions: OTHER: Buteyko breathing technique|OTHER: Diaphragmatic breathing technique.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: All-Trans Retinoic Acid (ATRA) Combining Dexamethasone Versus High-dose Dexamethasone for Initial Treatment of Primary Immune Thrombocytopenia (ITP)
Status: WITHDRAWN
Conditions: Purpura|Idiopathic Thrombocytopenic Purpura
Interventions: DRUG: All-Trans Retinoid Acid(ATRA)|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vertebral Column Resection (VCR) in Congenital Kyphoscoliosis (CKS)
Status: UNKNOWN
Conditions: Congenital Spinal Deformity|Congenital Kyphoscoliosis
Interventions: PROCEDURE: Posterior Vertebral Column Resection (PVCR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of L-Arginine Supplementation in the Treatment of Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: L-arginine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Vibegron Administered Orally for 12 Weeks to Women With Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Vibegron|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of a Silicone Hydrogel for Daily Disposable Wear
Status: COMPLETED
Conditions: Refractive Error
Interventions: DEVICE: FID122819 contact lenses|DEVICE: Stenfilcon A contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Clinical Trial to Investigate the Effect on the Pharmacokinetics of YH14755 Compared to Co-administration of Rosuvastatin and Metformin SR in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rosuvastatin, Metformin, YH14755|DRUG: YH14755
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Study to Evaluate IBI112 in the Treatment of Psoriasis With Moderate to Severe Plaque Psoriasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Psoriasis
Interventions: DRUG: IBI112|DRUG: placebo /IBI112|DRUG: IBI112
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Irinotecan Hydrochloride Liposome Combined With Capecitabine for Second-line Treatment in Patients With Advanced or Metastatic Biliary Tract Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Biliary Tract Carcinoma
Interventions: DRUG: irinotecan hydrochloride liposome injection|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Lanreotide to Treat Polycystic Kidney Disease
Status: UNKNOWN
Conditions: Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Interventions: DRUG: Lanreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inter-field Strength Agreement of CMR Derived Strain
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DIAGNOSTIC_TEST: Cardiovascular Magnetic Resonance (CMR) imaging at 1.5T|DIAGNOSTIC_TEST: Cardiovascular Magnetic Resonance (CMR) imaging at 3T
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Using a Lower Limb Robotic Device for Patients With Chronic Stroke
Status: COMPLETED
Conditions: Gait, Hemiplegic|Quality of Life|Vascular Stiffness|Stroke
Interventions: DEVICE: Alter G Bionic Leg|OTHER: Normal therapy (physiotherapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Social Regulation of Threat-related Vigilance and Arousal
Status: NOT_YET_RECRUITING
Conditions: Psychological Trauma, Historical|Discrimination, Racial|Emotion Regulation|Social Interaction|Hypervigilance|Anxiety
Interventions: BEHAVIORAL: social support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of APG-1252 in Patients With Myelofibrosis Who Progressed After Initial Therapy
Status: WITHDRAWN
Conditions: Myelofibrosis
Interventions: DRUG: APG-1252|DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amnion Chorion Membrane Combined With Allograft Bone Putty for the Management of Intrabony Defects
Status: COMPLETED
Conditions: Periodontal Regeneration
Interventions: PROCEDURE: Combined regenerative technique|PROCEDURE: Open flap debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Th-1 Dendritic Cell Immunotherapy Plus Standard Chemotherapy for Pancreatic Adenocarcinoma
Status: RECRUITING
Conditions: Pancreatic Adenocarcinoma|Pancreatic Cancer
Interventions: BIOLOGICAL: Autologous DC vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy in Controlling Myopia in Young Children Using a Novel Spectacle Lens
Status: RECRUITING
Conditions: Myopia|Juvenile Myopia|Myopia Progression
Interventions: DEVICE: Single vision, impact-resistant spectacle lenses; Test Arm|DEVICE: Single vision, impact-resistant spectacle lenses; Control Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Clinical Trial of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis
Status: COMPLETED
Conditions: ANCA-Associated Vasculitis
Interventions: DRUG: Avacopan|DRUG: Prednisone|DRUG: Cyclophosphamide|BIOLOGICAL: Rituximab|DRUG: Azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pralatrexate in Patients With Relapsed or Refractory Cutaneous T-cell Lymphoma
Status: COMPLETED
Conditions: Cutaneous T-cell Lymphoma
Interventions: DIETARY_SUPPLEMENT: Vitamin B12|DIETARY_SUPPLEMENT: Folic Acid|DRUG: Pralatrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Canagliflozin, 300 mg|DRUG: Metformin XR, 500 mg|DRUG: CANA/MET XR FDC, Formulation 1, 150 mg/1,000 mg|DRUG: CANA/MET XR FDC, Formulation 2, 150 mg/1,000 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COMPARISON OF SECTIONAL MATRIX VERSUES CIRCUMFERENTIAL MATRIX FOR RECONSTRUCTION OF PROXIMAL CONTACT IN CLASS 2 RESTORATIONS
Status: RECRUITING
Conditions: Tooth Decay
Interventions: DEVICE: Sectional matrix|DEVICE: Circumferential matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pazopanib In Combination With Lapatinib In Adult Patients With Relapsed Malignant Glioma
Status: COMPLETED
Conditions: Glioma
Interventions: DRUG: pazopanib|DRUG: lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Study With Eftilagimod Alpha (a Soluble LAG-3 Fusion Protein) and Pembrolizumab in Patients With Recurrent or Metastatic HNSCC
Status: ACTIVE_NOT_RECRUITING
Conditions: HNSCC
Interventions: DRUG: eftilagimod alpha|DRUG: pembrolizumab (KEYTRUDA®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accuracy of Hystro-Salpingo-Foam-Sonography (HYFOSY) as Tubal Patency Test in Comparison to Laparoscopy in Infertile Patients
Status: NOT_YET_RECRUITING
Conditions: Infertility, Female
Interventions: DIAGNOSTIC_TEST: Hystro-Salpingo-Foam-Sonography (HYFOSY)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of TAK-438, Amoxicillin and Clarithromycin in the First Line Eradication of H. Pylori
Status: COMPLETED
Conditions: H. Pylori Infection
Interventions: DRUG: TAK-438|DRUG: Lansoprazole|DRUG: Amoxicillin|DRUG: Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chiauranib Plus Weekly Paclitaxel in Patients With Platinum-refractory or Platinum-resistant Recurrent Ovarian Cancer
Status: RECRUITING
Conditions: Ovarian Cancer|Relapsed or Refractory|Chiauranib|Paclitaxel
Interventions: DRUG: chiauranib|DRUG: Placebo|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prolectin-M in COVID-19 Patients Having Mild to Moderate Symptoms Not Requiring Oxygen Support.
Status: COMPLETED
Conditions: COVID-19
Interventions: OTHER: Prolectin-M; a (1-6)-alpha-D-Mannopyranose class|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FR901228 in Treating Patients With Refractory Stomach Cancer or Gastroesophageal Junction Cancer
Status: TERMINATED
Conditions: Adenocarcinoma of the Esophagus|Adenocarcinoma of the Stomach|Recurrent Esophageal Cancer|Recurrent Gastric Cancer
Interventions: DRUG: romidepsin|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Standing, Lying and Stockings on Blood Bio-markers (v.1)
Status: UNKNOWN
Conditions: Chronic Venous Insufficiency
Interventions: DEVICE: SIGVARIS® Class 2 - RAL: 23-32.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Switching to Potential Reduced Exposure Products in Adult Smokers
Status: COMPLETED
Conditions: Tobacco Use Disorder|Oral Nicotine Pouch Use|Smoking Behaviors|Harm Reduction|Toxic Effect of Tobacco and Nicotine|Carcinogenesis
Interventions: DEVICE: ZYN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Prevention of Bleeding in Patient With Cirrhosis Undergoing Dental Extraction
Status: COMPLETED
Conditions: Liver Cirrhosis|Coagulopathy
Interventions: DRUG: Desmopressin|BIOLOGICAL: blood transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analog Classroom Study Comparison of ADDERALL XR With STRATTERA in Children Aged 6-12 With ADHD
Status: COMPLETED
Conditions: ADHD
Interventions: DRUG: Mixed amphetamine salts (ADDERALL XR)|DRUG: Atomoxetine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate AD04 in Adults With Alcohol Use Disorder (AUD) and Selected Serotonin Transporter Polymorphisms
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: DRUG: AD04 (ondansetron)|DRUG: Matching placebo|DEVICE: Companion Diagnostic for Genetic Testing|BEHAVIORAL: Brief Psychological Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Capecitabine vs Gemcitabine Plus Cisplatin in Resected Extrahepatic Cholangiocarcinoma
Status: COMPLETED
Conditions: Cholangiocarcinoma|Biliary Tract Cancer|Adjuvant Chemotherapy|Capecitabine|Gemcitabine|Cisplatin
Interventions: DRUG: Gemcitabine plus cisplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Biofeedback in Patients With Acute Cerebral Infarction
Status: COMPLETED
Conditions: Acute Ischemic Stroke|Biofeedback|Autonomic Dysfunction, Cognitive Function|Psychological Distress
Interventions: BEHAVIORAL: heart rate variability biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Immunogenicity of Recombinant Vesicular Stomatitis Vaccine for Ebola-Zaire (rVSV[Delta]G-ZEBOV-GP) for Pre-Exposure Prophylaxis (PREP) in People at Potential Occupational Risk for Ebola Virus Exposure
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: rVSV-Zebov GP vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 3 Study of a Daclatasvir/Asunaprevir/BMS-791325 Fixed Dose Combination (FDC) in Subjects With Chronic Hepatitis C Genotype 1
Status: COMPLETED
Conditions: Hepatitis C Virus
Interventions: DRUG: DCV/ASV/BMS-791325
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: mHealth Intervention to Prevent Postpartum Smoking Relapse
Status: COMPLETED
Conditions: Tobacco Use Cessation|Pregnancy Related
Interventions: BEHAVIORAL: xSmoker app|BEHAVIORAL: SMS|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: EUS-guided Versus Laparoscopic Gastrojejunostomy for Malignant Gastric Outlet Obstruction
Status: NOT_YET_RECRUITING
Conditions: Gastric Outlet Obstruction
Interventions: DEVICE: EUS-guided gastroenterostomy|OTHER: Laparoscopic gastroenterostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II/III Study of Efficacy and Safety of SHR7280 Tablets in Subjects With Menorrhagia With Uterine Fibroids
Status: RECRUITING
Conditions: Uterine Fibroids With Menorrhagia
Interventions: DRUG: SHR7280 tablets|DRUG: SHR7280 tablets|DRUG: PlaceboSHR7280 tablets blank preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cell Therapy in Multiple System Atrophy
Status: ACTIVE_NOT_RECRUITING
Conditions: MSA
Interventions: BIOLOGICAL: Autologous Mesenchymal Stem Cells|BIOLOGICAL: Autologous Mesenchymal Stem Cells|BIOLOGICAL: Autologous Mesenchymal Stem Cells|BIOLOGICAL: Autologous Mesenchymal Stem Cells|BIOLOGICAL: Autologous Mesenchymal Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bimatoprost as a Treatment for Graves' Orbitopathy
Status: RECRUITING
Conditions: Graves Ophthalmopathy
Interventions: DRUG: Bimatoprost Ophthalmic
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: San Diego Bleeding Esophageal Varices Study
Status: COMPLETED
Conditions: Survival and Control of Bleeding
Interventions: PROCEDURE: Emergency portacaval shunt|PROCEDURE: Emergency and long-term endoscopic sclerotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Multicenter Human Randomized Controlled Evaluation of NOTES® Cholecystectomy
Status: UNKNOWN
Conditions: Gall Bladder Diseases
Interventions: PROCEDURE: NOTES Cholecystectomy|PROCEDURE: Laparoscopic Cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Breast Reconstruction With Acellular Dermal Matrix in the Setting of Breast Cancer Treatment
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: Reconstruction with ADM.|PROCEDURE: Skin or nipple sparing mastectomy|PROCEDURE: Reconstruction with implant|PROCEDURE: Total submuscular coverage|PROCEDURE: Partial submuscular coverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, PK, and Pharmacodynamics(PD) of IONIS APOCIII-LRx in Healthy Volunteers With Elevated Triglycerides
Status: COMPLETED
Conditions: Elevated Triglycerides (TG)
Interventions: DRUG: APOC-III-L-Rx|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Estramustine, Docetaxel, and Carboplatin in Treating Patients With Prostate Cancer That Has Not Responded to Hormone Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: carboplatin|DRUG: docetaxel|DRUG: estramustine phosphate sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: First Study to Evaluate the Capacity of Maraviroc Drug to Protect Against HIV Infection in Samples of Rectal Mucosa From Healthy Volunteers
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Maraviroc|DRUG: TVD 300/200 QD|DRUG: Maraviroc
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Ph 1 Study of VS-4718, a FAK Inhibitor, in Combination With Nab-paclitaxel and Gemcitabine in Advanced Cancer Subjects
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: Part B, Cohort 1- VS-4718, nab-paclitaxel, gemcitabine|DRUG: Part B, Cohort 2- VS4718, nab-paclitaxel, gemcitabine|DRUG: Part A- VS-4718, nab-paclitaxel, gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Rubber Dam Isolation Versus Cotton Roll Isolation on Bonded Fissure Sealant Retention
Status: UNKNOWN
Conditions: Dental Caries in Children|Dental Caries on Pit and Fissure Surface|Dental Leakage
Interventions: DEVICE: Rubber Dam Set|DEVICE: Dental Cotton Roll
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effects of Nitrate-rich Beetroot Juice in Pregnant Women With High Blood Pressure
Status: UNKNOWN
Conditions: Preeclampsia|Hypertension|Endothelial Dysfunction|Nitric Oxide|Oxidative Stress|Proteinuria|Kidney Diseases
Interventions: DIETARY_SUPPLEMENT: Beetroot Juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outcome of Exercise With a Towel in Elderly With Sarcopenia
Status: COMPLETED
Conditions: Sarcopenia
Interventions: PROCEDURE: Exercise with a towel|PROCEDURE: Home-based exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Yoga Therapy and Aerobic Exercise on Anti-Mullerian Hormone in Young Women With Polycystic Ovary Syndrome
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome|Anti-Mullerian Hormone Deficiency|Female Infertility Endocrine
Interventions: OTHER: Structured yoga therapy program|OTHER: Aerobic exercise training program|OTHER: Combined yoga and aerobic training program|OTHER: Nutritional management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Immunotherapy Combined With Chemoradiation for Patients With High-risk reseCtable Extrahepatic chOlangiocaRcinoma and gallblaDder Cancer
Status: UNKNOWN
Conditions: Biliary Tract Cancer|Extrahepatic Cholangiocarcinoma|Gallbladder Cancer
Interventions: DRUG: Chemotherapy|OTHER: Observation|PROCEDURE: Immunotherapy|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Corticosteroids in Children With Cellulitis
Status: TERMINATED
Conditions: Cellulitis
Interventions: DRUG: Dexamethasone|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Vildagliptin vs. Thiazolidinedione as add-on Therapy to Metformin in Patients With Type 2 Diabetes Not Controlled With Metformin Alone
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: vildagliptin|DRUG: thiazolidinedione (TZD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Nicardipine and Remifentanil on Surgical Visual Field
Status: NOT_YET_RECRUITING
Conditions: Other Complications of Surgical and Medical Procedures
Interventions: PROCEDURE: Nicardipine|PROCEDURE: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Tolerability of LX101 for Inherited Retinal Dystrophy Associated With RPE65 Mutations
Status: ACTIVE_NOT_RECRUITING
Conditions: Inherited Retinal Dystrophy Associated With RPE65 Mutations
Interventions: GENETIC: LX101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TB Host Directed Therapy
Status: UNKNOWN
Conditions: Tuberculosis
Interventions: DRUG: Everolimus 0.5 MG|DRUG: Auranofin 6 MG|DRUG: Vitamin D3|DRUG: CC-11050|DRUG: 2HRbZE/4HRb
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Alpha Lipoic Acid on Chemotherapy Induced Neurological Changes in Breast Cancer Patients
Status: RECRUITING
Conditions: Breast Cancer|Alpha Lipoic Acid|Paclitaxel|Neurologic Disorder|Chemotherapy
Interventions: DRUG: Alpha Lipoic Acid 600 MG Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Fufangdanshen Tablets in Mild to Moderate Vascular Dementia
Status: COMPLETED
Conditions: Vascular Dementia
Interventions: DRUG: Fufangdanshen Tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Flexitouch Plus With Connectivity on Compliance in 30 Patients With Breast Cancer-Related Lymphedema.
Status: COMPLETED
Conditions: Breast Cancer Lymphedema
Interventions: DEVICE: Flexitouch Plus with Cellular Connectivity (FT-CC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Cy-Atg Vs Cy-Flu-Atg for the Conditioning Therapy in Allo-HCT
Status: COMPLETED
Conditions: Bone Marrow Failure Syndromes
Interventions: DRUG: Cyclophosphamide-fludarabine-anti thymocyte globulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality as a Motor Priming Tool for Cognitive-Motor Rehabilitation Among Sub-Acute Stroke Patients
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: Virtual Reality Training Session|BEHAVIORAL: Motor-Relearning Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Pharmacokinetic Study of the Combination of Digoxin and Polythylene Glycol Loxenatide Injection in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Digoxin|DRUG: PEX168
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Cold Laser Plaque Ablation for Lower Limb Arterial Stenosis and Occlusive Lesions
Status: RECRUITING
Conditions: Arterial Disease of Legs|Atherosclerosis of Artery
Interventions: DEVICE: Cold laser plaque ablation|DEVICE: The excimer laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Detection of Lesions Using PET (Positron Emission Tomography) Probe During Secondary Cytoreductive Surgery for Recurrent Ovarian, Fallopian Tube and Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Fallopian Tube|Primary Peritoneal
Interventions: PROCEDURE: Positron Emission Tomography|RADIATION: 18F-Fluoro-2-deoxy-D-lucose|PROCEDURE: Cytoreductive surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Trial for High Intensity Laser Therapy (HILT) for Elbow Epicondylosis
Status: UNKNOWN
Conditions: Chronic Pain|Elbow Tenderness|Elbow Pain Upon Active Resistive Motion
Interventions: DEVICE: HILTERAPIA HIRO 3.0
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study: Ulthera System for the Treatment of Rosacea
Status: COMPLETED
Conditions: Erythematotelangiectatic Rosacea
Interventions: DEVICE: Ulthera System providing one treatment per cheek|DEVICE: Ulthera System providing two treatments per cheek
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Adult Adipose-Derived Regenerative Cell Injection Into Chronic Partial-Thickness Rotator Cuff Tears
Status: ACTIVE_NOT_RECRUITING
Conditions: Rotator Cuff Tear|Rotator Cuff Tendinitis
Interventions: DEVICE: Adipose Derived Regenerative Cells|DRUG: Corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral Activation Therapy and Nicotine Replacement Therapy in Increasing Smoking Cessation
Status: ACTIVE_NOT_RECRUITING
Conditions: Cigarette Smoker|Tobacco Use Disorder
Interventions: BEHAVIORAL: Behavioral Intervention|OTHER: Laboratory Biomarker Analysis|DRUG: Nicotine Patch|OTHER: Questionnaire Administration|BEHAVIORAL: Smoking Cessation Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Integrated Care in Psychotic Disorders With Severe Mental Illness
Status: RECRUITING
Conditions: Schizophrenia|Schizophreniform Disorder|Schizoaffective Disorder|Delusional Disorder|Psychotic Disorder NOS|Bipolar Disorder|Severe Major Depression With Psychotic Features
Interventions: OTHER: Integrated care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: User-friendliness of a Portable Driving Simulator
Status: RECRUITING
Conditions: Parkinson Disease|Multiple Sclerosis|Stroke
Interventions: DEVICE: Low-Fidelity PDS|DEVICE: High Fidelity Fixed-Base Simulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Chloroquine Diphosphate for the Treatment of Severe Acute Respiratory Syndrome Secondary to SARS-CoV2
Status: COMPLETED
Conditions: SARS-CoV Infection|Severe Acute Respiratory Syndrome (SARS) Pneumonia
Interventions: DRUG: Chloroquine diphosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Evaluation and Verification of Ventricular Enhancement
Status: ACTIVE_NOT_RECRUITING
Conditions: Ischemic Cardiomyopathy|Heart Failure
Interventions: DEVICE: Revivent TC Ventricular Enhancement System|DRUG: GDMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Efficacy of Convalescent Methylene Blue Treated (MBT) Plasma From Donors Recovered From Coronavirus Disease 2019 (COVID-19)
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Convalescent anti-SARS-CoV-2 MBT Plasma|DRUG: Standard Medical Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does B Vitamin Supplementation Decrease Homocysteine Concentrations in Newborns
Status: COMPLETED
Conditions: Mild Hyperhomocysteinemia
Interventions: DRUG: 5-formyltetrahydrofolate (10 mg/ml) (Pharmachemie bv)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: MRx0518 in Patients With Solid Tumours Waiting Surgical Removal of the Tumour
Status: UNKNOWN
Conditions: Melanoma|Breast Cancer|Uterine Cancer|Ovarian Cancer|Prostate Cancer|Urethral Cancer|Bladder Cancer|Renal Cancer|Lung Cancer|Head and Neck Cancer
Interventions: DRUG: MRx0518 Capsules|DRUG: MRx0518/placebo Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: Ribociclib|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zevalin® Followed by Rituxan® Maintenance in Previously Treated Low Grade Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin|Lymphoma, Low-Grade
Interventions: DRUG: ibritumomab tiuxetan (Zevalin®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D and Residual Beta-Cell Function in Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Ergocalciferol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Lenalidomide in Combination With Cyclosporine A in Patients With Myelodysplastic Syndromes
Status: TERMINATED
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: lenalidomide|DRUG: cyclosporine A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of "Beauty Drink" on Regulation of Blood Pressure Effect by Clinical Trial
Status: COMPLETED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: Beauty Drink|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Dose and Response of Dietary Nitrate in Healthy and Active Men
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: sodium nitrate|DIETARY_SUPPLEMENT: Beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adaptive Plasticity Following Rehabilitation in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Voluntary-based upper limb motor rehabilitation|BEHAVIORAL: Passive upper limb mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Innovative Digital Therapeutic for Smoking Cessation
Status: COMPLETED
Conditions: Smoking Cessation|Nicotine Addiction|Drug Addiction|Drug Dependence|Tobacco Dependence|Tobacco Use Disorder|Substance Use Disorder|Tobacco Smoking
Interventions: DEVICE: CT-101-M|DEVICE: QuitGuide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Two Fixed Doses of ZX008 (Fenfluramine HCl) in Children and Young Adults With Dravet Syndrome
Status: COMPLETED
Conditions: Dravet Syndrome|Seizure Disorder
Interventions: DRUG: ZX008 (Fenfluramine Hydrochloride)|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nature-Oriented Chatbots on Older Adults' Mental Health
Status: NOT_YET_RECRUITING
Conditions: Depression|Loneliness|Happiness|Connection With Nature|Anxiety
Interventions: BEHAVIORAL: Nature-Oriented Chatbots
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Bioactive Microstructured Anti Microbial Precoated Surface Implant Versus Non-coated Surface Implant in Type 2 Diabetic Patients in the Mandible
Status: COMPLETED
Conditions: Dental Implant|Diabetes Mellitus, Type 2
Interventions: OTHER: Pre coated impants|OTHER: Non coated implant surface
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Oral Lactulose Versus Lactulose Enema in Hepatic Encephalopathy
Status: NOT_YET_RECRUITING
Conditions: Hepatic Encephalopathy|Chronic Liver Disease
Interventions: DRUG: Tap water|DRUG: Lactulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sublingual Tablets of Grass Pollen Allergen Extract
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: 300 IR grass pollen allergen extract tablet|DRUG: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Cognitive-behavioral Program of Coping With Psychological Stress in People With Retinitis Pigmentosa
Status: COMPLETED
Conditions: Vision Disorders|Stress, Psychological|Psychopathy|Self Efficacy
Interventions: BEHAVIORAL: A cognitive-behavioral intervention program|OTHER: Standard intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety, Pharmacokinetics, and Antiviral Activity of a Human Monoclonal Antibody (VRC01) in HIV-Infected Adults Undergoing a Brief Treatment Interruption
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: VRC01
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Tart Cherry on Uric Acid and Biomarkers of CVD Risk in Healthy Individuals
Status: COMPLETED
Conditions: Uric Acid|Cardiovascular Diseases|Gout
Interventions: DIETARY_SUPPLEMENT: Tart cherry juice|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Short-Term Beta-Cell Rest in Adolescents and Young Adults With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Obesity|Overweight|Diabetes Mellitus, Type 2
Interventions: DRUG: Metformin|DRUG: Insulin|BEHAVIORAL: Nutrition counseling|BEHAVIORAL: Exercise counseling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Duloxetine for Pain in Older Adults With Knee Osteoarthritis (OA)
Status: COMPLETED
Conditions: Pain Reduction|Function Improvement
Interventions: DRUG: duloxetine HCL|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Study to Investigate the Safety and Performance of Diaphragm Stimulation Coupled With Mechanical Ventilation
Status: WITHDRAWN
Conditions: Diaphragm Issues|Ventilator-Induced Lung Injury|Tracheostomy
Interventions: DEVICE: NeuRx Diaphragm Pacing System (DPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Avastin (Bevacizumab) in Combination With Fotemustine in Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: DRUG: bevacizumab [Avastin]|DRUG: fotemustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-blinded, Placebo-controlled, Dose-ranging Study of Cardene® I.V. in Pediatric Subjects With Hypertension
Status: WITHDRAWN
Conditions: Hypertension
Interventions: DRUG: Cardene® I.V.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Loteprednol and Tobramycin Versus Tobramycin and Dexamethasone, in the Treatment of Blepharokeratoconjunctivitis
Status: COMPLETED
Conditions: Conjunctivitis|Keratitis|Blepharitis
Interventions: DRUG: Loteprednol and tobramycin|DRUG: Tobramycin and dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Between Two Oral Nicotine Sublingual Tablets, 2 mg and 4 mg
Status: COMPLETED
Conditions: Tobacco Dependence
Interventions: DRUG: Nicotine Sublingual Tablet Mint (NSTM)|DRUG: Marketed Nicotine Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Web-based Rehabilitation for Persistent Physical Symptoms.
Status: ACTIVE_NOT_RECRUITING
Conditions: Persistent Physical Symptoms|Indoor Environment Associated Symptoms|Indoor Air Associated Symptoms|Chronic Fatigue Syndrome
Interventions: BEHAVIORAL: Case formulation with web-program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neadjuvant Multi-agent Chemotherapy or Letrozole Plus Ribociclib in Luminal B/HER2-negative Breast Cancer.
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Ribociclib|DRUG: Letrozole 2.5mg|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Examining Vascular Outcomes in COPD Inpatients (AIM 1) Examining Early Rehabilitation on Discharged COPD Patients (AIM 2)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: OTHER: AIM 2: Pulmonary Rehabilitation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of A Mindfulness Resiliency Training Program for Refugees Living in Jordan
Status: COMPLETED
Conditions: Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)|Mental Health Wellness 1|War-Related Trauma
Interventions: BEHAVIORAL: Refugees Mindfulness Resiliency Training|BEHAVIORAL: Mindfulness Resiliency Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Measurement Algorithm Control and Optimization With Subsequent Performance Evaluation of Sanmina Non-invasive Biosensors During a Standardized Meal Test in Patients With Diabetes Mellitus Type 1 and Type 2
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: Sanmina Biosensor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Salt Supplementation in Gitelman Syndrome
Status: RECRUITING
Conditions: Gitelman Syndrome
Interventions: DIETARY_SUPPLEMENT: Salt (NaCl)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT