pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Juvista in the Non-surgical Improvement of Existing Scars
Status: WITHDRAWN
Conditions: Scars
Interventions: DRUG: Juvista|DRUG: Placebo|DRUG: Juvista
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Retrospective Study of EGFR-TKIs,Gefitinib, Erlotinib and Osimertinib in NSCLC Patients Treatment
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer (NSCLC)|EGFR-TKI Resistant Mutation|EGFR-TKI Sensitizing Mutation|Germline Mutations|Somatic Mutation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Amlodipine Plus Botulinum Toxin for Focal Dystonia
Status: COMPLETED
Conditions: Focal Dystonia
Interventions: DRUG: Amlodipine plus Botulinum toxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability, and Effects in and on the Body of Healthy Young and Elderly Male and Female Subjects of Ascending Multiple Oral Doses of ASP3652
Status: COMPLETED
Conditions: Healthy Subjects|Pharmacokinetics of ASP3652|Pharmacodynamics of ASP3652
Interventions: DRUG: ASP3652|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Pilates Exercise in Children With Juvenile Idiopathic Arthritis
Status: COMPLETED
Conditions: Juvenile Arthritis|Cardiorespiratory Fitness|Quality of Life
Interventions: OTHER: Pilates exercises|OTHER: Conventional physical therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nasal Photodisinfection in All Patients Presenting for Surgery for a Wide Range of Surgical Procedures
Status: COMPLETED
Conditions: Surgical Site Infections|Nosocomial Infection|Healthcare Associated Infections
Interventions: COMBINATION_PRODUCT: methylene blue 0.01%/chlorhexidine gluconate 0.25% + light activation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Impact of a Preoperative Nerve Block in Foot and Ankle Surgery on the Consumption of Sevoflurane
Status: WITHDRAWN
Conditions: Ankle Arthropathy|Anesthesia; Functional|Ankle Arthritis
Interventions: DRUG: Ropivacaine injection|DRUG: Dextrose 5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: See and Treat in an Outpatient Setting in Women Above 45 Years With Cervical Dysplasia
Status: COMPLETED
Conditions: Cervical Dysplasia|Cervical Lesion|Cervix Disease
Interventions: PROCEDURE: Cone biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Shock Efficacy Study Comparing Fixed Tilt and Fixed Pulse Width in a General Implantable-Cardioverter Population
Status: ACTIVE_NOT_RECRUITING
Conditions: Ventricular Arrythmia
Interventions: DEVICE: Fixed Tilt (65%)|DEVICE: Fixed Pulse Width
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Managing Appropriate Prescribing in COPD
Status: COMPLETED
Conditions: COPD|Comorbidities and Coexisting Conditions
Interventions: BEHAVIORAL: Desktop helper|BEHAVIORAL: E-learning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Endocuff Enhanced Colonoscopy: Does it Improve Polyp Detection and Make Rectal Retroflexion Unnecessary
Status: COMPLETED
Conditions: Colorectal Cancer|Colonic Polyps
Interventions: DEVICE: Use of Endocuff during colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: High Intensity Training to Improve Diaphragm Functioning in Persons With Chronic Nonspecific Low Back Pain
Status: RECRUITING
Conditions: Low Back Pain|Chronic Low-back Pain|Chronic Pain
Interventions: OTHER: High intensity training|OTHER: Moderate intensity training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Security of an Endovascular Treatment as First Choice Procedure Compared With a Standard Intravenous Thrombolytic Therapy Treatment for Patients With Acute Ischemic Stroke Within 4.5 Hours After Onset
Status: COMPLETED
Conditions: Acute Ischaemic Stroke
Interventions: PROCEDURE: EVT (endovascular treatment )|PROCEDURE: IVT (intravenous thrombolytic therapy)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multiple Risk Factor Intervention Trial
Status: COMPLETED
Conditions: Metabolic Disturbance|Sedentary Behavior
Interventions: BEHAVIORAL: Experimental: Guidelines-based physical activity|BEHAVIORAL: Experimental: Guidelines-based healthy eating|BEHAVIORAL: Stretching exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neurotropism and Neuroinflammation in COVID-19 Patients With Delirium.
Status: COMPLETED
Conditions: Covid19|Delirium|Post-traumatic Stress Disorder
Interventions: BIOLOGICAL: serology testing profiles description|BIOLOGICAL: immune response characterization|OTHER: in vivo brain PET-TSPO acquisitions|OTHER: brain MRI assessment|BEHAVIORAL: neurocognitive assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effectiveness of Foley Airway Stylet Tool on Proseal LMA Insertion
Status: COMPLETED
Conditions: Anesthesia Insertion Complication|Airway Morbidity
Interventions: DEVICE: Foley Airway Stylet Tool|DEVICE: introducer-tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Demonstration of Equivalence and Early Onset of a Novel Anti-allergic Nasal Spray Compared to Marketed Nasal Spray
Status: COMPLETED
Conditions: Allergic Rhinitis|Allergic Conjunctivitis|Hayfever
Interventions: DRUG: Rhinocort|DRUG: Budesolv|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Of CVX-060, An Anti-Angiogenic COVX-Body, In Combination With Sunitinib In Patients With Advanced Renal Cell Carcinoma
Status: TERMINATED
Conditions: Solid Tumor
Interventions: DRUG: CVX-060 + sunitinib|DRUG: CVX-060 + sunitinib|DRUG: CVX-060 + sunitinib|DRUG: CVX-060 + sunitinib|DRUG: CVX-060 + sunitinib|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study of 2 mg Alprazolam OD Tablets Under Non-Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ALPRAZOLAM ORALLY DISINTEGRATING TABLETS, 2.0 MG|DRUG: NIRAVAM TM 2 mg orally disintegrating tablets, single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Effectiveness of Two Approved Drugs in Lowering High Cholesterol (0733-224)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: MK0733, simvastatin|DRUG: Comparator: simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Antibiotic Treatment on Outcome in Patients With Ventilator-Associated Tracheobronchitis
Status: COMPLETED
Conditions: Respiratory Tract Diseases|Nosocomial Infections
Interventions: DRUG: antibiotic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perfluorohexyloctane (NOV03) for the Treatment of Signs and Symptoms of Dry Eye Disease (DED)
Status: COMPLETED
Conditions: Dry Eye Disease (DED)
Interventions: DRUG: NOV03|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anticoagulation Length in Cancer Associated Thrombosis
Status: TERMINATED
Conditions: Cancer|Thrombosis|Venous Thromboembolism|Deep Vein Thrombosis|Pulmonary Embolus
Interventions: DRUG: Low Molecular Weight Heparin (LMWH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of GDC-0810 on the Pharmacokinetics of Pravastatin in Healthy Female Subjects of Non-Childbearing Potential
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: GDC-0810|DRUG: Pravastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: 980nm Diode Laser in the Treatment of Periodontal Disease in Cardiac Patients
Status: UNKNOWN
Conditions: Myocardial Infarction|Periodontal Diseases
Interventions: DEVICE: diode laser 980nm|DEVICE: scaling root planing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study of Monovalent Omicron XBB.1.5 Vaccine as a Booster in Adults
Status: WITHDRAWN
Conditions: COVID-19
Interventions: BIOLOGICAL: SCB-2023B vaccine, a monovalent Omicron XBB.1.5 recombinant SARS-CoV-2 trimeric S-protein subunit vaccine for COVID-19|BIOLOGICAL: SCB-2019 vaccine, a monovalent wu-hu1 SARS-CoV-2 trimeric S-protein subunit vaccine for COVID-19
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Observational Study to Analyse the Impact of Nurse Support and Disease Related Factors on Long- Term Adherence to Betaferon Treatment
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis (RRMS)
Interventions: DRUG: Interferon beta-1b (Betaseron, BAY86-5046)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Recurrent Application of Liquid-PRF on Hard and Soft Tissues
Status: COMPLETED
Conditions: Liquid-PRF|A-PRF Plus
Interventions: OTHER: Liquid platelet-rich fibrin|OTHER: Advanced Platelet-rich fibrin plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of GW823093 In Japanese Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: GW823093 15mg|DRUG: GW823093 placebo capsule|DRUG: GW823093 30mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Tolerability of Lidocaine 5% Spray in Treatment of Lifelong Premature Ejaculation Patients.
Status: COMPLETED
Conditions: Lidocaine Spray
Interventions: DRUG: Lidocaine 5% spray|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Assess the Long Term Safety and Tolerability of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-833)
Status: COMPLETED
Conditions: Hypercholesterolemia|Familial Hypercholesterolemia
Interventions: DRUG: Ezetimibe|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Preventive Analgesia by Injection of a Local Anesthetic Before Vaginal Incision for Hysterectomy by vNOTES Approach
Status: NOT_YET_RECRUITING
Conditions: Hysterotomy; Affecting Fetus
Interventions: DRUG: Naropeine|OTHER: questionnaires|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Modified Constraint-induced Movement Therapy in Children With Brain Damage
Status: COMPLETED
Conditions: Brain Damage|Cerebral Palsy|Traumatic Brain Damage
Interventions: BEHAVIORAL: Modified Constraint-induced Movement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Pharmacokinetics of Tropifexor in Subjects With Mild, Moderate, or Severe Hepatic Impairment Compared to Healthy Control Subjects
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease
Interventions: DRUG: LJN452
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spinal Versus General Anesthesia for Transabdominal Preperitoneal (TAPP) Repair of Inguinal Hernia
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Transabdominal Preperitoneal repair of inguinal hernia|PROCEDURE: Transabdominal Preperitoneal repair of inguinal hernia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Health Gatherings - For Your Health After Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Neoplasm|Genital Neoplasms, Male|Urogenital Neoplasms|Neoplasm, Prostate|Genital Diseases, Male|Prostatic Diseases
Interventions: BEHAVIORAL: Cultural CBSM|BEHAVIORAL: Standard CBSM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy With NOVOCART® Disc Plus (ADCT) for the Treatment of Degenerative Disc Disease in Lumbar Spine
Status: COMPLETED
Conditions: Intervertebral Disc Displacement|Intervertebral Disc Degeneration
Interventions: DRUG: NOVOCART® Disc plus|DEVICE: NOVOCART® Disc basic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Adverse Events and Effectiveness of OnabotulinumtoxinA in Participants Undergoing Open Abdominal Ventral Hernia Repair for the Achievement of Primary Fascial Closure Without the Use of Component Separation Technique
Status: WITHDRAWN
Conditions: Ventral Hernia|Abdominal Hernia
Interventions: DRUG: BOTOX Dose A|DRUG: Placebo for BOTOX|DRUG: BOTOX Dose B|DRUG: BOTOX Dose C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tofacitinib in the Treatment of Refractory Axial Spondyloarthritis Patients: A Dose Escalation Study
Status: COMPLETED
Conditions: Axial Spondyloarthritis
Interventions: DRUG: Tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venous Thromboembolism in Hematologic Malignancy and Hematopoietic Cell Transplant Patients: a Retrospective Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Thrombosis, Venous|Bleeding Hemorrhage|Venous Thromboembolic Disease|Hematologic Malignancy|Thrombocytopenia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Deep Versus Standard Muscle Relaxation on Intra-operative Safety
Status: RECRUITING
Conditions: Neuromuscular Blockade|Rocuronium|Anesthetics|Anesthesia Complication|Neuromuscular Blocking Agents|Surgery--Complications
Interventions: OTHER: Deep neuromuscular block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Sleep Disturbance on Cognition and Quality of Life in Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Sleep|Quality of Life
Interventions: DIAGNOSTIC_TEST: Functional Magnetic Resonance Imaging at rest and in activation with attentional task
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Comparison of Paclitaxel-based Three Regimens Concurrent With Radiotherapy for Patients With Local Advanced Esophageal Cancer
Status: COMPLETED
Conditions: Stage III Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Paclitaxel and Cisplatin|DRUG: Paclitaxel and Fluorouracil|DRUG: Paclitaxel and Carboplatin|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Insulin Resistance Study
Status: SUSPENDED
Conditions: Insulin Resistance|Metabolic Syndrome x
Interventions: DRUG: N-acetylcysteine 20% 4ml|DRUG: N-acetylcysteine 20% in 4 ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Most Closely Human Leukocyte Antigen (HLA)-Matched CMV-specific T Lymphocytes (Viralym-C)
Status: COMPLETED
Conditions: CMV Infections
Interventions: BIOLOGICAL: Viralym-C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PAVES Benchmarking Pilot Study of Daily Disposable Contact Lenses
Status: COMPLETED
Conditions: Refractive Errors
Interventions: DEVICE: Phase A - olifilcon B with Tangible Coatings|DEVICE: Phase B - etafilcon A with Tangible Coatings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Is There a Correlation Between the Pulmonary Artery Pressure and the Acceleration of the Flow in the Pulmonary Artery Evaluated by Transesophageal Echocardiography (TOE) ?
Status: UNKNOWN
Conditions: Ventilated Patients
Interventions: OTHER: the measure TRVMAX|OTHER: the measure of the pulmonary artery|OTHER: the direct measure of the pulmonary pressures
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) in Cystic Fibrosis (CF) Participants 12 to Less Than 24 Months of Age
Status: RECRUITING
Conditions: Cystic Fibrosis
Interventions: DRUG: ELX/TEZ/IVA|DRUG: IVA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SWOG-9239 Reduction of Immunosuppression Plus Interferon Alfa and Combination Chemotherapy in Treating Patients With Malignant Tumors That Develop After Organ Transplant
Status: COMPLETED
Conditions: Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: bleomycin sulfate|BIOLOGICAL: recombinant interferon alfa|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: methotrexate|DRUG: prednisone|DRUG: vincristine sulfate|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Intensity ShockWave Therapy for ED in Non Responders to PDE5i - a Double Blind Placebo Controlled Study
Status: UNKNOWN
Conditions: Erectile Dysfunction
Interventions: DEVICE: Extracorporeal Shockwave Therapy Generator (Vascuspec)|DEVICE: Low intensity shock wave therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tracheal Occlusion To Accelerate Lung Growth (TOTAL) Trial for Severe Pulmonary Hypoplasia
Status: COMPLETED
Conditions: Congenital Diseases|Diaphragmatic Hernia|Pulmonary Hypoplasia
Interventions: PROCEDURE: fetal endoluminal tracheal occlusion|OTHER: watchful waiting during pregnancy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypnosis for the Management of Anxiety and Breathlessness During a Pulmonary Rehabilitation Program
Status: COMPLETED
Conditions: COPD|Dyspnea|Anxiety
Interventions: BEHAVIORAL: Hypnosis|BEHAVIORAL: Relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of SGN-LIV1A Plus Pembrolizumab for Patients With Locally-Advanced or Metastatic Triple-Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple Negative Breast Neoplasms
Interventions: DRUG: ladiratuzumab vedotin|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MIRAI-MRI: Comparing Screening MRI for Patients at High Risk for Breast Cancer Identified by Mirai and Tyrer-Cuzick
Status: RECRUITING
Conditions: Breast Cancer
Interventions: PROCEDURE: Breast MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Serological Study in Children 12 to 23 Months Vaccinated With MMR (Measles, Mumps and Rubella)
Status: COMPLETED
Conditions: Mumps|Rubella|Measles
Interventions: BIOLOGICAL: MMR (Mumps, Measles and Rubella)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hand Forceps vs. Conventional One-hand Technique for Fetal Head Extraction During Cesarean Section
Status: UNKNOWN
Conditions: Pregnancy Related|Delivery Complication|Cesarean Delivery Affecting Fetus
Interventions: PROCEDURE: Fetal head extraction technique during the cesarean section
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: AZD1775 Continued Access Study to Assess Safety and Tolerability for Patients Enrolled in AZD1775 Clinical Pharmacology Studies
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Wee-1 kinase inhibitor AZD1775
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Zoledronic Acid in Osteoporosis
Status: RECRUITING
Conditions: Osteoporosis
Interventions: DRUG: "Zoledronic acid", "Reclast®"|DRUG: "Zoledronic acid", "Reclast®" and "active vitamin D", "alfacalcidol®"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Family Education on Functional Level, Activity Level and Families in Children With Cerebral Palsy
Status: UNKNOWN
Conditions: Children With Cerebral Palsy
Interventions: OTHER: Physiotherapy and rehabilitation treatment in a special education and rehabilitation center.|OTHER: Family-based home exercise.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Promoting Transactional Supports to Optimize Social Communication Outcomes for Infants and Their Families
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Social Communication Growth Charts (SCGC)|BEHAVIORAL: Parent-Implemented (P-I) Condition|BEHAVIORAL: Clinician-Implemented (C-I) Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation For The Treatment Of Gastro-Intestinal Acute GVHD
Status: WITHDRAWN
Conditions: Gastro-Intestinal Acute Graft Versus Host Disease (GI-aGVHD)
Interventions: BIOLOGICAL: Fecal Microbiota Transplantation (FMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study of GSK Biologicals' Herpes Zoster Vaccine GSK1437173A When Co-administered With Prevenar13 in Adults Aged 50 Years and Older
Status: COMPLETED
Conditions: Herpes Zoster
Interventions: BIOLOGICAL: HZ/su vaccine GSK1437173A|BIOLOGICAL: Prevenar13
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Risk Adapted Treatment for Primary Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Leukemia, Myelocytic, Acute
Interventions: DRUG: Ara-C|OTHER: Autologous peripheral blood stem cell transplantation.|OTHER: Allogeneic matched related or unrelated donor transplant.|DRUG: G-CSF|OTHER: CD34+ selection.|OTHER: Mylotarg purging before autologous PBSC transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Milnacipran for Chronic Pain in Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis|Degenerative Joint Disease|Chronic Pain
Interventions: DRUG: Milnacipran|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of the Dynesys(R) Spinal System
Status: TERMINATED
Conditions: Degenerative Spondylolisthesis or Retrolisthesis|Spinal Stenosis|Stenosing Lesion.
Interventions: DEVICE: Posterior Pedicle Screw System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Evaluating the Effect of 2D Antiscatter Grids on CBCT Image Quality
Status: RECRUITING
Conditions: Prostate Cancer|Head and Neck Cancers|Upper Abdomen Cancers
Interventions: DEVICE: Research CBCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transforaminal Epidural Steroid Injection With Pulsed Radiofrequency for Chronic Lumbosacral Radicular Pain Management
Status: UNKNOWN
Conditions: Radicular; Neuropathic, Lumbar, Lumbosacral|Low Back Pain|Back Pain With Radiation
Interventions: DRUG: Celestone|PROCEDURE: pulsed radiofrequency treatment|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Synergistic Treatment for Hepatocellular Carcinoma (HCC) Using TACE With Antiangiogenesis
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: Transcatheter Arterial Chemoembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Rejuvesol® Washed RBC in Sickle Cell Patients Requiring Frequent Transfusions
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: Rejuvesol|PROCEDURE: Blood transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of Increasing Physical Activity to Reduce Children's Visceral Fat
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Pediatric Obesity Intervention (STANDARD)|BEHAVIORAL: Pediatric Obesity Intervention + High Activity (ADDED)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Single İncision Laparoscopic Cholecystectomy Versus Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Laparoscopic Surgical Procedures
Interventions: PROCEDURE: Laparoscopic Cholecystectomy (Single Incision)|PROCEDURE: Laparoscopic Cholecystectomy (Conventional)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Culturally Adapted Parenting Intervention for Spanish-Speaking Parents in Improving Outcomes of Younger Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia Survivors at Risk for Late Neurocognitive Effects
Status: COMPLETED
Conditions: Cancer Survivor|Childhood Acute Lymphoblastic Leukemia in Remission|Childhood Acute Myeloid Leukemia in Remission|Cognitive Side Effects of Cancer Therapy
Interventions: OTHER: Educational Intervention|OTHER: Educational Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neoadjuvant Listeria or Daratumumab in Prostate Cancer
Status: WITHDRAWN
Conditions: Malignant Neoplasms of Male Genital Organs|Prostate Cancer
Interventions: DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Evaluation of Atrial Fibrillation Treatment With Focal Impulse and Rotor Modulation Guided Procedures
Status: COMPLETED
Conditions: Persistent Atrial Fibrillation
Interventions: PROCEDURE: Standard PVI Ablation|PROCEDURE: FIRM-Guided Procedure and PVI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparing HAI-90Y (SIR-spheres)+Chemotx LV5FU2 Versus Chemotx LV5FU2 Alone to Treat Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DEVICE: HAI-90Y radioembolization (SIR-spheres injection)|DRUG: systemic chemotherapy LV5FU2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Outreach and Prevention at ALcohol Venues in East Africa Study (OPAL-East Africa- Aim 1)
Status: RECRUITING
Conditions: HIV/AIDS
Interventions: BEHAVIORAL: HIV-focused mobilization|BEHAVIORAL: Multi-disease-focused mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of a New Dilution and Injection Volume of AbobotulinumtoxinA for the Treatment of Glabellar Lines
Status: COMPLETED
Conditions: Glabellar Frown Lines
Interventions: BIOLOGICAL: AbobotulinumtoxinA|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Social Presence and Perception in Virtual Reality on Pain (SPP)
Status: COMPLETED
Conditions: Pain Threshold
Interventions: BEHAVIORAL: VR Close Other|BEHAVIORAL: VR Alone|BEHAVIORAL: VR Stranger|BEHAVIORAL: Video Close Other
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy, Safety and Efficiency Study of CARTO® 3 System Guided THERMOCOOL® Catheter Ablation Versus Fluoroscopy Guided Ablation With the Pulmonary Vein Ablation Catheter® (PVAC®)
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Radiofrequency Ablation procedure|DEVICE: Radiofrequency Ablation procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal CO2 Removal With the Hemolung RAS for Mechanical Ventilation Avoidance During Acute Exacerbation of COPD
Status: TERMINATED
Conditions: Acute Exacerbation of COPD
Interventions: DEVICE: Hemolung Respiratory Assist System|DEVICE: Invasive mechanical ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Venetoclax Based Regimen in Prevention Relapse of Consecutive MRD Positive AML Patients
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia|Measurable Disease
Interventions: DRUG: Venetoclax, Azacitidine|DRUG: Venetoclax, daunorubicin, cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Whether Taking BI 1358894 for 8 Weeks Helps Adults With Post-traumatic Stress Disorder
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: DRUG: BI 1358894|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Denosumab Effect on Bone Quality and Function After Lumbar Fusion Surgery
Status: COMPLETED
Conditions: Osteopenia|Spine Fusion|Denosumab Allergy
Interventions: DRUG: Denosumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of SODB® (Superoxide Dismutase by Bionov®) in the Physical Condition Improvement in Healthy Subjects
Status: UNKNOWN
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: SODB®|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Safety, Efficacy and Tolerability Study in Pediatric Subjects With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Levalbuterol|DRUG: Levalbuterol UDV TID|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Compassion-based Intervention for Internal and External Shame
Status: COMPLETED
Conditions: Shame|Compassion
Interventions: BEHAVIORAL: Describing a shameful experience using a self-compassionate prompt|BEHAVIORAL: Receiving compassionate responses from confederates|BEHAVIORAL: Describing a shameful experience using a neutral prompt|BEHAVIORAL: Receiving no response from confederates
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of GMA161 in Patients With Idiopathic Thrombocytopenic Purpura (ITP)
Status: TERMINATED
Conditions: Idiopathic Thrombocytopenic Purpura
Interventions: BIOLOGICAL: GMA161|BIOLOGICAL: GMA161|BIOLOGICAL: GMA161|BIOLOGICAL: GMA161|BIOLOGICAL: GMA161
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Listening to Music on Anxiety Postoperative in a Postanesthesic Care Unit (PACU) After Spinal Anesthesia
Status: UNKNOWN
Conditions: Spinal Anesthesia
Interventions: OTHER: music therapy|OTHER: No music therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Changes in Nerve Electro Physiologic Properties in Children Before and After Correction of Malnutrition
Status: COMPLETED
Conditions: Stunting|Severe Acute Malnutrition|Wasting
Interventions: COMBINATION_PRODUCT: Nutritional Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Whole Genome Sequencing (ChromoSeq) as an Adjunct to Conventional Genomic Profiling in AML and MDS
Status: RECRUITING
Conditions: Whole Genome Sequencing|Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: DEVICE: ChromoSeq
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intracoronary Thrombus Detection by Magnetic Resonance Imaging
Status: COMPLETED
Conditions: Angina Pectoris|Angina, Stable|Angina, Unstable|Myocardial Infarction
Interventions: OTHER: Magnetic Resonance Imaging|DEVICE: Optical Coherence Tomography|PROCEDURE: Invasive Coronary Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Galcanezumab (LY2951742) in Adults With Treatment-Resistant Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Galcanezumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Safety, Immunogenicity and Ex-vivo Efficacy of Two Candidate Malaria Transmission Blocking Vaccines, Pfs25-IMX313 and Pfs45/48 Administered Alone and in Combination, in Matrix-M Adjuvant
Status: NOT_YET_RECRUITING
Conditions: Plasmodium Falciparum Malaria
Interventions: BIOLOGICAL: Pfs25-IMX313, Pfs48/45
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Drug Treatment Combined With Drug and Risk Reduction Counseling to Prevent of HIV Infection and Death Among Injection Drug Users
Status: TERMINATED
Conditions: HIV Infections|Opioid-Related Disorders
Interventions: DRUG: Buprenorphine/Naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Home-based Study Using Mobile Technology to Test Whether BI 1358894 is Effective in People With Depression
Status: TERMINATED
Conditions: Depressive Disorder, Major
Interventions: DRUG: BI 1358894|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Storytelling With or Without Social Contextual Information in Children With Autistic Spectrum Disorder and Typical Development
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Healthy
Interventions: BEHAVIORAL: Storytelling with social contextual information|BEHAVIORAL: Storytelling without social contextual information|OTHER: Children with ASD|OTHER: Children with TD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Decursin/Decursinol Angelate (CognIQTM)
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: 800mg dietary supplement CognIQTM (4 capsules) by oral at hour 0
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Avastin in Combination With Docetaxel in Ovarian/Fallopian Tube/Peritoneum Carcinoma
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Malignant Tumor of Peritoneum
Interventions: DRUG: Avastin|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness and Safety of Radiesse for the Correction of Nasolabial Folds in China
Status: COMPLETED
Conditions: Correction of the Moderate to Severe Nasolabial Folds
Interventions: DEVICE: Radiesse injectable implant (dermal filler)|DEVICE: Restylane injectable implant (dermal filler)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TACO Crossover TRIAL
Status: COMPLETED
Conditions: Transfusion-associated Circulatory Overload|Blood Transfusion Reaction
Interventions: PROCEDURE: Autologous RBC transfusion|PROCEDURE: Saline transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Choline Supplementation During Pregnancy: Impact on Attention and Social Withdrawal
Status: ACTIVE_NOT_RECRUITING
Conditions: Child Development|Prenatal Stress
Interventions: DRUG: Choline|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oligo-antigenic Diet in the Treatment of Chronic Anal Fissures.
Status: COMPLETED
Conditions: Anal Fissures Treatment and Oligoantigenic Diet
Interventions: DIETARY_SUPPLEMENT: sham oligoantigenic diet associated to lifestyle instruction|DIETARY_SUPPLEMENT: oligoantigenic diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liquid Meal Study With Insulin Lispro With/Without Recombinant Human Hyaluronidase PH20 (rHuPH20) and Regular Human Insulin With rHuPH20 to Compare Pharmacokinetics, Postprandial Glycemic Response, and Optimal Insulin Dose in Participants With Type 2 Diabetes Mellitus (T2DM)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Humalog|DRUG: Humulin-R|DRUG: Recombinant human hyaluronidase PH20 (rHuPH20)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Spot Marching Exercise Test in Chronic Obstructive Pulmonary Disease
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: 6 minute walk test (6 MWT)|OTHER: Spot marching test (SMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Comparison Between Modified William's Airway and U Shaped Guedl's Airway
Status: COMPLETED
Conditions: Endotracheal Intubation
Interventions: DEVICE: U shaped Guedl's airway|DEVICE: Modified William's airway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Female Sex is an Independent Predictor of Death and Bleeding Among Fibrinolytic Treated Patients With AMI
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: fibrinolytic therapy or combination reduced fibrinolytic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of JNJ-54861911 on Amyloid Beta Processing in Cerebrospinal Fluid and Plasma in Patients With Prodromal Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: JNJ-54861911 10 mg|DRUG: JNJ-54861911 50 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Mild to Moderate Peri-implantitis Using an Oscillating Chitosan Device
Status: COMPLETED
Conditions: Peri-Implantitis
Interventions: DEVICE: Labrida BioClean|OTHER: Titanium curettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diagnosis of Bladder Outlet Obstruction Using Dynamic Urine Vibration "Holter" in Comparison to Pressure Flow Study
Status: UNKNOWN
Conditions: Bladder Outlet Obstruction
Interventions: DEVICE: Dynamic Urine Vibration "Holter"
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: 3 Month PHI PAD PoM Study
Status: COMPLETED
Conditions: Vascular Disease, Peripheral
Interventions: DRUG: GSK1278863|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Clinical Trial to Evaluate the Detection of Atrial Fibrillation for an One Day Versus More Than or Equal to Eight Days Using MEMO Patch PLUS in Individuals Aged ≥ 75 Years, or Those at High Risk of Stroke
Status: UNKNOWN
Conditions: Atrial Fibrillation/Flutter in Patients With High Risk of Stroke
Interventions: DEVICE: MEMO Patch PLUS for 1 day|DEVICE: MEMO Patch PLUS for More than 8-days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Transdiagnostic Sleep and Circadian Treatment for Depression
Status: COMPLETED
Conditions: Depression|Insomnia
Interventions: BEHAVIORAL: Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation Study in Healthy Female Volunteers: A Comparison of Two Neurotech Vital Devices Set up to Provide Different Types of Electrical Stimulation
Status: COMPLETED
Conditions: Healthy Female Volunteers
Interventions: DEVICE: Neurotech Vital Device|DEVICE: Modified Neurotech Vital Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Evaluation of a Locoregional Anesthesia Protocol by Pudendal Block in Reconstructive Surgery Clitoral
Status: UNKNOWN
Conditions: Reduction in Pain Within 24 Hours of Surgery
Interventions: PROCEDURE: pudendal block
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: EluNIR Ridaforolimus Eluting Coronary Stent System in Patients at High Bleeding Risk (HBR)- EluNIR HBR Study
Status: COMPLETED
Conditions: Coronary Stenosis
Interventions: DEVICE: Percutaneous Coronary Intervention (PCI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Single Ascending Dose Study for Evaluation of Safety, Tolerability and Pharmacokinetics of L606
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: L606 (Liposomal Treprostinil) Inhalation Solution 51ug|DEVICE: L606 Inhalation System|OTHER: Placebo Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER