pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Difference in Wound Size Reduction Comparing Two Frequently Used Wound Dressings in Everyday Care
Status: COMPLETED
Conditions: Wound Heal
Interventions: OTHER: application of a polyacrylate wound pad|OTHER: Hydrocellular foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Nasal Steroids and Montelukast on Olfactory Functions in Patients With Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Montelukast,mometazon froat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of the RSV D46cpΔM2-2 Vaccine in RSV-Seropositive Children and RSV-Seronegative Infants and Children
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: D46cpΔM2-2 vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Non-invasive Prediction of Microvascular Invasion in Hepatocellular Carcinoma by Blood-Oxygen-Level Dependent Magnetic Resonance Imaging (BOLD MRI)
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: BOLD MRI test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Omalizumab in Preventing Bronchoconstriction Following Environmental Cat Dander Exposure in Patients With Cat Dander-induced Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Omalizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fluzoparib and Camrelizumab in Treating Patients With R/M NPC That Progressed After First-line Chemotherapy
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma|Nasopharyngeal Cancer
Interventions: DRUG: Fluzoparib and Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atezolizumab + Stereotactic Radiation in Triple-negative Breast Cancer and Brain Metastasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Atezolizumab|PROCEDURE: Stereotactic radiosurgery (SRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Lasmiditan on Simulated Driving Performance in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lasmiditan|DRUG: Placebo|DRUG: Diphenhydramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Exercise Training on Quality of Life and Disease Progression in Fibrosing Interstitial Lung Patients
Status: RECRUITING
Conditions: Fibrosis, Pulmonary|Pulmonary Rehabilitation
Interventions: OTHER: Pulmonary rehabilitation exercise programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Once-daily Simultaneous Modulated Accelerated Thoracic Radiotherapy in Limited Small-cell Lung Cancer
Status: UNKNOWN
Conditions: Small Cell Lung Cancer
Interventions: RADIATION: q.d. RT|RADIATION: b.i.d.RT|DRUG: etoposide and cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study Evaluating Certolizumab Pegol Compared to Placebo in Subjects With axSpA Without X-ray Evidence of AS
Status: COMPLETED
Conditions: Axial Spondyloarthritis|Nonradiographic Axial Spondyloarthritis|Nr-axSpA
Interventions: BIOLOGICAL: Certolizumab Pegol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Detection of Circulating Tumor DNA in p16- Locally Advanced Head Neck Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: OTHER: Detecton of circulating tumor DNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Once Daily Antiretroviral Therapy in HIV Infected Adults Treated With HAART
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: emtricitabine, FTC (drug)|DRUG: didanosine, ddI (drug)|DRUG: efavirenz (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiac Safety of Dihydroartemisinin-Piperaquine Amongst Pregnant Women in Tanzania
Status: COMPLETED
Conditions: Malaria|Pregnancy Malaria|Cardiotoxicity|Cardiac Safety|Parasitemia
Interventions: DRUG: sulfadoxine-pyrimethamine (SP)|DRUG: dihydroartemisinin-piperaquine (DHA-PQP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Performance of a Silicone Implant for Fecal Incontinence Treatment (SimplyFI)
Status: RECRUITING
Conditions: Fecal Incontinence
Interventions: PROCEDURE: Medical Device (SimplyFI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Psychological Therapy in Chronic Pain and Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia|Chronic Pain
Interventions: OTHER: control group: usual medical care|BEHAVIORAL: MBPM- Mindfulness-Based Pain Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study on Hormone Receptor Positive HER2 Positive Breast Cancer of RCB1-2 After Neoadjuvant Treatment With Trastuzumab Combined With Parezumab
Status: RECRUITING
Conditions: Early-stage Breast Cancer|HER2-positive Breast Cancer|Adjuvant Treatment After Trastuzumab|RCB Classification 1-2|Neratini
Interventions: DRUG: Trastuzumab and nelatinib|DRUG: Trastuzumab and Parstuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study In Healthy Elderly People To Evaluate Safety, Toleration, Pharmacokinetics and Pharmacodynamics of Multiple Oral Doses Of PF-06743649
Status: TERMINATED
Conditions: Healthy Elderly
Interventions: DRUG: PF-06743649|DRUG: Placebo|DRUG: PF-06743649|DRUG: Placebo|DRUG: PF-06743649|DRUG: Placebo|DRUG: PF-06743649|DRUG: Placebo|DRUG: PF-06743649|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: S0420, Sorafenib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer
Status: COMPLETED
Conditions: Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma|Recurrent Metastatic Squamous Neck Cancer With Occult Primary|Recurrent Salivary Gland Cancer|Recurrent Squamous Cell Carcinoma of the Hypopharynx|Recurrent Squamous Cell Carcinoma of the Larynx|Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity|Recurrent Squamous Cell Carcinoma of the Nasopharynx|Recurrent Squamous Cell Carcinoma of the Oropharynx|Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Recurrent Verrucous Carcinoma of the Larynx|Recurrent Verrucous Carcinoma of the Oral Cavity|Salivary Gland Squamous Cell Carcinoma|Stage IV Squamous Cell Carcinoma of the Hypopharynx|Stage IV Squamous Cell Carcinoma of the Nasopharynx|Stage IVA Salivary Gland Cancer|Stage IVA Squamous Cell Carcinoma of the Larynx|Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVA Squamous Cell Carcinoma of the Oropharynx|Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVA Verrucous Carcinoma of the Larynx|Stage IVA Verrucous Carcinoma of the Oral Cavity|Stage IVB Salivary Gland Cancer|Stage IVB Squamous Cell Carcinoma of the Larynx|Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVB Squamous Cell Carcinoma of the Oropharynx|Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVB Verrucous Carcinoma of the Larynx|Stage IVB Verrucous Carcinoma of the Oral Cavity|Stage IVC Salivary Gland Cancer|Stage IVC Squamous Cell Carcinoma of the Larynx|Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVC Squamous Cell Carcinoma of the Oropharynx|Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVC Verrucous Carcinoma of the Larynx|Stage IVC Verrucous Carcinoma of the Oral Cavity|Tongue Cancer|Untreated Metastatic Squamous Neck Cancer With Occult Primary
Interventions: DRUG: sorafenib tosylate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Nimotuzumab, Radiation Therapy and Cisplatin Versus Radiation Therapy and Cisplatin for Treatment of Stage IB e IVA UCC(CORUS)
Status: WITHDRAWN
Conditions: Carcinoma|Adenocarcinoma|Uterine Cervix Adenosquamous Carcinoma
Interventions: DRUG: Nimotuzumab|DRUG: Cisplatin|RADIATION: Brachytherapy|DRUG: Cisplatin|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label, Long-term Safety Study of Secukinumab in Polymyalgia Rheumatica (PMR)
Status: RECRUITING
Conditions: Polymyalgia Rheumatica
Interventions: BIOLOGICAL: Secukinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regular Use of aPDT in the Management and Prevention of Periodontitis Symptoms in Diabetic Patients
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 2|Pre-diabetes|Periodontal Diseases|Periodontitis
Interventions: DEVICE: Lumoral Treatment|OTHER: Standard oral hygiene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Efficacy and Safety Study of CD07805/47 Topical Gel in Subjects With Persistent Facial Erythema
Status: WITHDRAWN
Conditions: Erythema
Interventions: DRUG: CD07805/47 Gel 0.5%|DRUG: CD07805/47 Gel Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Online Insomnia Treatment Program
Status: RECRUITING
Conditions: Insomnia|Sleep|Sleep Disturbance|Sleep Disorder|Sleep Hygiene|Sleep Initiation and Maintenance Disorders
Interventions: BEHAVIORAL: Full Sleep|BEHAVIORAL: Path to Better Sleep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Physical Exercise on Endothelial Function in Pregnant Women
Status: COMPLETED
Conditions: Pregnancy|Preeclampsia|Exercise
Interventions: BEHAVIORAL: Regular aerobic physical exercise|BEHAVIORAL: Activities of daily living
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Randomized Study in Children Ages Birth Through Three Years Undergoing Unilateral Cataract Extraction With or Without Lens Replacement
Status: COMPLETED
Conditions: Unilateral Cataract Extraction|Congenital Cataract
Interventions: DRUG: OMS302|DRUG: Phenylephrine HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Reflexologic Insoles for Primary Dysmenorrhea
Status: NOT_YET_RECRUITING
Conditions: Primary Dysmenorrhea
Interventions: DEVICE: Reflexologic Magnetic Insole Group|DEVICE: Orthopedic Insole Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of STI-3031 in Patients With Selected Relapsed or Refractory Solid Tumors
Status: WITHDRAWN
Conditions: Solid Tumor|Refractory Tumor|Relapsed Solid Tumor
Interventions: BIOLOGICAL: STI-3031
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Circadian Time Restricted Eating
Status: RECRUITING
Conditions: Circadian Rhythm|Cardiometabolic Health|Weight Loss|Cardiovascular Health|Time Restricted Feeding
Interventions: BEHAVIORAL: Circadian Based Time Restricted Eating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of the Transarterial Supraselective Embolization of the Prostate to Treat the Urinary Symptoms.
Status: COMPLETED
Conditions: Transurethral Resection of Prostate|Artery Embolization|Benign Prostatic Hyperplasia|Lower Urinary Tract Symptoms
Interventions: PROCEDURE: Transarterial Supraselective Embolization of the prostate|PROCEDURE: Transurethral Resection of the prostate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pupillary Dilation After Incremental Tetanic Stimulations Under Ketamine Sedation
Status: COMPLETED
Conditions: Pain|Anesthesia
Interventions: DRUG: ketamine|PROCEDURE: Tetanic stimulations of incremental intensities
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Labor Induction in Low-risk Nulliparous Women at 39 Weeks of Gestation to Reduce Cesarean: A Randomized Trial of Induction Versus Expectant Management in France (FRENCH-ARRIVE)
Status: RECRUITING
Conditions: Cesarean Section
Interventions: PROCEDURE: Elective labor induction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of the Supraflex Cruz 60 Micron Versus the Ultimaster Tansei 80 Micron in HBR PCI Population
Status: COMPLETED
Conditions: Cardiac Disease|PCI|High Bleeding Risk
Interventions: DEVICE: Supraflex Cruz 60 Micron|DEVICE: Ultimaster Tansei 80 Micron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Reduction of Cardiovascular Risk in Severe Mental Illness
Status: UNKNOWN
Conditions: Severe Mental Illness|Schizophrenia|Bipolar Disorder|Affective Disorders|Schizoaffective Disorder|Personality Disorder
Interventions: BEHAVIORAL: Lifestyle counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase I/II Study of Paclitaxel Plus CPT-11 in Pts. With 2nd Line Chemotherapy of Inoperable or Recurrent GC.
Status: WITHDRAWN
Conditions: Gastric Cancer
Interventions: DRUG: Taxol|DRUG: Campt, Topotesin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resilience Measurement in Older Adults With Late-Stage Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer Stage III|Lung Cancer Stage IV
Interventions: BEHAVIORAL: Self System Therapy for Older Adults with Advanced Lung Cancer (SST-LC) Resilience
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lenalidomide and Gemcitabine in Relapsed or Refractory Peripheral T-cell Lymphomas
Status: TERMINATED
Conditions: Peripheral T-cell Lymphomas (PTCL)
Interventions: DRUG: Lenalidomide and Gemcitabine (Dose level 11)|DRUG: Lenalidomide and Gemcitabine (Dose level 21)|DRUG: Lenalidomide and Gemcitabine (Dose level 31)|DRUG: Lenalidomide and Gemcitabine (Dose level 41)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Nasal Deposition and Clearance of Ketorolac Solution Administered Using the Valois Nasal Spray Device
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Ketorolac tromethamine|DRUG: Ketorolac tromethamine|DRUG: Ketorolac tromethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility of ExoNET
Status: ACTIVE_NOT_RECRUITING
Conditions: Stroke|Cerebral Vascular Accident
Interventions: DEVICE: ExoNet Tuned to Gravity Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Hyperandrogenism Versus Insulin Resistance in Infertile Polycystic Ovary Syndrome (PCOS) Women
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Orlistat/Meal Replacement/Lifestyle Modification|DRUG: Loestrin 1/20|DRUG: Combination of treatments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction
Status: COMPLETED
Conditions: Post-Operative Pain|Third Molar Extraction
Interventions: DRUG: Intranasal Placebo|DRUG: Intranasal Morphine 15 mg|DRUG: Immediate Release Oral Morphine 60 mg|DRUG: Intravenous morphine|DRUG: Intranasal morphine 7.5 mg|DRUG: Oral placebo|DRUG: Intravenous placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intensive Conditioning withTHI/Bu/Flu/Ara-C in Allo-HSCT for Myeloid Malignancies With Extramedullary Involvement
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Neoplasm|Chronic Myelomonocytic Leukemia|Myeloid Sarcoma|Extramedullary Myeloid Tumor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: St. John's Wort for Tobacco Cessation
Status: COMPLETED
Conditions: Smoking|Nicotine Dependence
Interventions: DRUG: Placebo|DRUG: St. John's Wort-900 mg/day|DRUG: St. John's Wort-1800mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of UC Versus EA on Sex Hormones in Obese Infertile Patients With PCOs
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome
Interventions: DEVICE: Ultrasound cavitation in group A|DEVICE: Electro acupuncture in group B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Donor Immune Cells (TGFbi NK Cells) and Isatuximab for the Treatment of Relapsed or Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Recurrent Multiple Myeloma|Refractory Multiple Myeloma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration and Biopsy|DRUG: Cyclophosphamide|DRUG: Dexamethasone|PROCEDURE: Echocardiography|BIOLOGICAL: Isatuximab|OTHER: Questionnaire Administration|BIOLOGICAL: Universal Donor Expanded TGF-beta-imprinted NK Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography Using [18F]-Labeled Substance P Antagonist Receptor Quantifier in Finding Disease in Patients With Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: OTHER: high performance liquid chromatography|OTHER: pharmacological study|RADIATION: [18F]-labeled substance P antagonist receptor quantifier
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Effect of Mild, Moderate, and Severe Hepatic Impairment on Pharmacokinetics of Sitravatinib
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: sitravatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Efficacy of Tocilizumab With or Without Glucocorticoid Discontinuation in Rheumatoid Arthritis Participants
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Placebo matched to prednisone|DRUG: Prednisone|BIOLOGICAL: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Risperidone vs Placebo as add-on Therapy in Patients With Generalized Anxiety Disorder Who Are Sub-optimally Responding to Standard Therapy.
Status: COMPLETED
Conditions: Anxiety Disorders
Interventions: DRUG: risperidone oral tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Modified Laryngeal Handshake Technique
Status: COMPLETED
Conditions: Airway Complication of Anesthesia
Interventions: PROCEDURE: Conventional laryngeal handshake technique|PROCEDURE: Modified laryngeal handshake technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Parecoxib in Total Knee Arthroplasty
Status: RECRUITING
Conditions: Pain, Postoperative|Pain, Acute|Analgesia|Analgesic Nephropathy|Analgesic Adverse Reaction|Knee Osteoarthritis
Interventions: DRUG: Intravenous study drug|OTHER: Intravenous saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Influenza Vaccines in Adults, FLUVACS-year 4
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Fluzone|BIOLOGICAL: Flumist|OTHER: Physiologic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Different Montages of Transcranial Direct Current Stimulation Tongue Strength
Status: UNKNOWN
Conditions: Healthy
Interventions: DEVICE: Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Of Avelumab In Combination With Other Cancer Immunotherapies In Advanced Malignancies (JAVELIN Medley)
Status: TERMINATED
Conditions: Advanced Cancer
Interventions: DRUG: Avelumab|DRUG: Utomilumab|DRUG: PF-04518600|DRUG: PD 0360324|DRUG: CMP-001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Negative Predictive Value of Drug Provocation Tests to Beta-lactams
Status: TERMINATED
Conditions: Drug Hypersensitivity
Interventions: OTHER: Evaluation of reexposure to a negatively tested betalactam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Low-Intensity Chemotherapy, Ponatinib and Blinatumomab in Treating Patients With Philadelphia Chromosome-Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia With BCR-ABL1|Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Recurrent Acute Lymphoblastic Leukemia|Refractory Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: Blinatumomab|DRUG: Cyclophosphamide|DRUG: Cytarabine|BIOLOGICAL: Filgrastim|DRUG: Methotrexate|BIOLOGICAL: Pegfilgrastim|DRUG: Ponatinib|BIOLOGICAL: Rituximab|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pharmacist Interventions Through the "Medication Therapy Management Pathway in Hypertensive Patients"
Status: NOT_YET_RECRUITING
Conditions: Hypertension|Medication Therapy Management
Interventions: BEHAVIORAL: Structured drug therapy management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Minimizing Pathologic Aspiration in Patients Undergoing Esophageal and Lung Resections for Cancer
Status: COMPLETED
Conditions: Esophageal Cancer|Lung Cancer
Interventions: OTHER: Oral Hygiene Education and Oral Hygiene Packets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cryptococcal Antigen Screening Plus Sertraline
Status: TERMINATED
Conditions: Cryptococcosis|Cryptococcal Infections|AIDS-Related Opportunistic Infections
Interventions: DRUG: Sertraline|DRUG: Placebo Oral Tablet|DRUG: Fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Histamine Glutamate Antagonism in Stroke
Status: COMPLETED
Conditions: Acute Cerebrovascular Accident|Cerebral Edema
Interventions: DRUG: Diphenhydramine|DRUG: Pantoprazole|DRUG: Famotidine|DRUG: Dextromethorphan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An add-on Study of E2007 in Patients With Refractory Partial Seizures Uncontrolled With Other Anti-epileptic Drugs (AEDs)
Status: COMPLETED
Conditions: Refractory Partial Seizures
Interventions: DRUG: E2007
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Lumateperone in the Treatment of Patients With Bipolar Mania
Status: RECRUITING
Conditions: Bipolar Disorder, Manic
Interventions: DRUG: Lumateperone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prediction of 30-Day Readmission Using Machine Learning
Status: UNKNOWN
Conditions: Infection|Heart Failure|Chronic Obstructive Pulmonary Disease|Asthma|Gout Flare|Chronic Kidney Diseases|Hypertensive Urgency|Atrial Fibrillation Rapid|Anticoagulants; Increased
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Population Pharmacokinetics of Anti-infectious Drugs in Children
Status: COMPLETED
Conditions: Pediatrics|Ceftazidime|Ciprofloxacin|Voriconazole
Interventions: DRUG: Ceftazidime|DRUG: Ciprofloxacin|DRUG: Voriconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Postoperative Pain Using Reciproc Versus One Shape Files in Patients With Irreversible Pulpitis
Status: UNKNOWN
Conditions: Pulpitis - Irreversible
Interventions: PROCEDURE: Reciproc single-file|PROCEDURE: One Shape single-file
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Migraine in Adolescents
Status: RECRUITING
Conditions: Migraine
Interventions: DEVICE: MRI|DEVICE: Thermal Stimuli|DEVICE: Pressure stimuli|BEHAVIORAL: Pain ratings|BEHAVIORAL: Pressure pain thresholds (PPT)|BEHAVIORAL: Conditioned pain modulation (CPM) efficiency|DIAGNOSTIC_TEST: Hormonal assessment|BEHAVIORAL: Migraine-related measures|BEHAVIORAL: Neural assessments|DIAGNOSTIC_TEST: Pubertal status
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: PG2 Concurrent With Chemoradiation for Locally Advanced Esophageal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer-related Fatigue|Survival|Tumor, Esophageal
Interventions: DRUG: Astragalus Polysaccharides 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD7 CAR T-cell for R/R CD7+ T Cell Lymphoma
Status: UNKNOWN
Conditions: Refractory and Relapsed T Cell Lymphoma
Interventions: BIOLOGICAL: Humanized CD7 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Magnetic Versus Manual Navigation-guided Ablation for Non-outflow Tract Premature Ventricular Contractions: a Prospective, Randomized, Controlled Trial
Status: UNKNOWN
Conditions: Premature Ventricular Contraction
Interventions: PROCEDURE: Catheter Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Dexamethasone Added to Ramosetron for Preventing Postoperative Nausea and Vomiting in Highly Susceptible Patients Following Spine Surgery
Status: COMPLETED
Conditions: Nausea|Vomiting
Interventions: DRUG: ramosetron with saline|DRUG: ramosetron with dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Taurine Effect on Glycemic, Lipidic and Inflammatory Profile in Individuals With Type 2 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Active comparator Taurine|OTHER: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pre and Post-gastrostomy Evaluation of GER in Children Using 24-hour pH Monitoring
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DEVICE: 24-hour esophageal pH monitoring using an ambulatory system (Ohmega, MMS, Enschede, The Netherlands).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Inspiratory Muscle Activation Pattern and Training Efficacy in Patients With Chronic Obstructive Pulmonary Disease After Acute Exacerbation
Status: COMPLETED
Conditions: Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: Threshold inspiratory muscle trainer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Innovative Chinese Herbal Formula for the Treatment of Gout
Status: RECRUITING
Conditions: Gout
Interventions: DRUG: HKIIM-KU formula|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Diagnosis of Alzheimer-like Dementia: Benefit of MRI and PET Imaging
Status: TERMINATED
Conditions: Alzheimer Disease|Mild Cognitive Impairment|Vascular Dementia
Interventions: OTHER: Magnetic resonance imaging|OTHER: Positron emission tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Does Sildenafil Increase Exercise Performance in Air Pollution?
Status: COMPLETED
Conditions: Pulmonary Hypertension|Pulmonary Artery Pressure|Exercise Performance|Air Pollution
Interventions: DRUG: sildenafil|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mindfulness-Based Cognitive Therapy (MBCT) and Cognitive Behavioral Therapy (CBT) for Depression in Diabetes Patients
Status: COMPLETED
Conditions: Depressive Symptoms
Interventions: BEHAVIORAL: Mindfulness-Based Cognitive Therapy (MBCT)|BEHAVIORAL: Cognitive Behavioral Therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Preclinical Toxicity andTherapeutic Efficacy of Kandhaga Rasayanam in Padarthamarai
Status: COMPLETED
Conditions: Tinea Infections Such as Tinea Corporis, Tinea Cruris, Tinea Pedis, Tinea Mannum, Tinea Barbae, Tinea Capitis Are Studied
Interventions: DRUG: kandhaga rasayanam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Androgen Effects in HIV-infected Women
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: 1 Transdermal Testosterone (Patch)|DRUG: 2 Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interest of Treatment of Obstructive Sleep Apnea Syndrome by Constant CPAP and Auto CPAP
Status: COMPLETED
Conditions: Obstructive Sleep Apnea Syndromes
Interventions: DEVICE: Constant Continuous Positive Airway Pressure|DEVICE: Automatic continuous Positive Airway Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sunitinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: B-cell Chronic Lymphocytic Leukemia|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia
Interventions: DRUG: sunitinib malate|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ⅰb Study on Autologous GC101 TIL Injection for the Treatment of Advanced Melanoma (MIZAR-002)
Status: RECRUITING
Conditions: Tumor Infiltrating Lymphocytes|Safety|Melanoma|Efficacy|Adverse Drug Event
Interventions: BIOLOGICAL: GC101 TIL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of 5% Lidocaine Patch With Placebo Patch in Subjects With Herpes Zoster Associated Pain
Status: COMPLETED
Conditions: Herpes Zoster Pain
Interventions: DRUG: 5% Lidocaine patch|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acceptability, Feasibility and Impact of Oral HIV Self-testing for Partner Testing Among Kenyan Adolescent Girls Aged 15-19 Years: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: BEHAVIORAL: Provision of multiple self-tests
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Topical Wound Oxygen (two2) Therapy
Status: TERMINATED
Conditions: Diabetic Ulcer
Interventions: DEVICE: Topical wound oxygen therapy|DEVICE: Topical wound oxygen Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Afatinib in Combination With Weekly Paclitaxel in the Second Line Treatment
Status: WITHDRAWN
Conditions: HER-2 Positive Gastric Cancer|Gastrooesophageal Cancer|Esophageal Cancer
Interventions: DRUG: Afatinib|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-ranging Study to Evaluate the Safety & Immunogenicity of a HIV Vaccine 732461 in Healthy HIV Seronegative Volunteers
Status: COMPLETED
Conditions: AIDS|HIV Infections
Interventions: BIOLOGICAL: HIV vaccine 732461
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Department of Defense PTSD Adaptive Platform Trial - Master Protocol
Status: RECRUITING
Conditions: Post Traumatic Stress Disorder
Interventions: DRUG: Intervention A Fluoxetine Hydrochloride (HCl)|DRUG: Intervention A Placebo|DRUG: Intervention B Vilazodone Hydrochloride (HCl)|DRUG: Intervention B Placebo|DRUG: Intervention C Daridorexant|DRUG: Intervention C Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current to Treat Epilepsy at Home
Status: ENROLLING_BY_INVITATION
Conditions: Epilepsies, Partial
Interventions: DEVICE: transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Functional Tests to Resolve Unsolved Rare Diseases. Rares.
Status: RECRUITING
Conditions: Intellectual Disability|Rubinstein-Taybi Syndrome|Cystic Fibrosis|Congenital Heart Defect|Periventricular Nodular Heterotopia|Neurodegeneration With Brain Iron Accumulation (NBIA)|Albinism
Interventions: GENETIC: Ex-vivo approach concerning 25 patients|GENETIC: In-vitro approach concerning 25 patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Characteristics of the Tsui Test and Pressure Waveform to Confirm Epidural Catheter Placement in Parturients With BMI ≥50 kg/m2
Status: COMPLETED
Conditions: Labor Pain
Interventions: DEVICE: Tsui test|DEVICE: epidural waveform analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bortezomib and Rituximab in Treating Patients With Mantle Cell Lymphoma Who Have Previously Undergone Stem Cell Transplantation
Status: COMPLETED
Conditions: Contiguous Stage II Mantle Cell Lymphoma|Noncontiguous Stage II Mantle Cell Lymphoma|Recurrent Mantle Cell Lymphoma|Stage I Mantle Cell Lymphoma|Stage III Mantle Cell Lymphoma|Stage IV Mantle Cell Lymphoma
Interventions: DRUG: bortezomib|BIOLOGICAL: rituximab|OTHER: laboratory biomarker analysis|OTHER: immunohistochemistry staining method|GENETIC: RNA analysis|GENETIC: gene expression analysis|GENETIC: DNA analysis|OTHER: pharmacological study|OTHER: pharmacogenomic studies|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of Multiple Doses of Itraconazole and Rifampin on the Single-Dose Pharmacokinetics of Mitapivat Sulfate (AG-348) in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: itraconazole|DRUG: rifampin|DRUG: mitapivat sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alternative Support for Rural and Isolated Women in an HMO
Status: COMPLETED
Conditions: Stress Disorders, Post-traumatic|Depression|Breast Cancer
Interventions: BEHAVIORAL: workbook/journal on coping with breast cancer|BEHAVIORAL: standard educational materials on breast cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Weight-Bearing After the Lapiplasty Mini-Incision Procedure (Mini3D)
Status: TERMINATED
Conditions: Hallux Valgus|Bunion
Interventions: DEVICE: Treatment of Hallux Valgus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Survivor Care Plan for Oral Cancer Patients-Effects on Physical-Psychological Functions and Return-to-Work
Status: UNKNOWN
Conditions: Oral Cancer
Interventions: COMBINATION_PRODUCT: Personalized Survivor Care Plan (PSCP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: MC1R-targeted Alpha-particle Therapy Trial in Adults With Advanced Melanoma
Status: RECRUITING
Conditions: Melanoma (Skin)|Metastatic Melanoma|Melanoma Stage IV|Melanoma, Uveal|Mucosal Melanoma|Melanoma Stage III
Interventions: DRUG: [203Pb]VMT01|DRUG: [212Pb]VMT01|DRUG: [212Pb]VMT01
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Flexible Thoracolumbar Brace on Spinal Alignment, Pain and Quality of Life in Subjects With Neuromuscular Scoliosis
Status: COMPLETED
Conditions: Neuromuscular Scoliosis
Interventions: DEVICE: thoracolumbar brace (Flexpine brace)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Freestyle Libre and Hospital Admissions in Type 2 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes
Interventions: DEVICE: Freestyle libre|OTHER: Nurse led structured intervention - hypoglycaemia education and diabetes treatment modification modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Escalation Study of Carboplatin Administration Into the Brain for Glioblastoma Multiforme
Status: WITHDRAWN
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Peritumoural carboplatin administration.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heme Iron Polypeptide for Iron Deficiency Anemia in Chronic Renal Failure
Status: COMPLETED
Conditions: Anemia|Renal Failure
Interventions: DRUG: Heme Iron Polypeptide (Proferrin)|DRUG: Iron sucrose (Venofer)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Anti-biofilm Effects of Ferumoxytol (Feraheme) Using an in Situ Biofilm Demineralization Model
Status: COMPLETED
Conditions: Dental Caries
Interventions: DRUG: Ferumoxytol/Hydrogen peroxide|DRUG: Hydrogen Peroxide|DRUG: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nutritional Safety and Metabolic Benefits of Oncometabolic Surgery for Obese Gastric Cancer Patients
Status: COMPLETED
Conditions: Oncology|Metabolic Disease|Gastric Cancer
Interventions: OTHER: Oncometabolic reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase IIIb Study to Evaluate the Safety and Tolerability of Herceptin SC With Perjeta and Docetaxel in Patients With HER2-positive Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Docetaxel|DRUG: pertuzumab [Perjeta]|DRUG: trastuzumab [Herceptin]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of Hydrocodone Bitartrate Controlled-release Capsules in Subjects With Chronic Low Back Pain
Status: COMPLETED
Conditions: Back Pain Lower Back Chronic
Interventions: DRUG: Placebo|DRUG: Hydrocodone bitartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ROMAN: Phase 3 Trial Investigating the Effects of GC4419 on Radiation Induced Oral Mucositis in Head/Neck Cancer Patients
Status: COMPLETED
Conditions: Oral Mucositis
Interventions: DRUG: GC4419 90mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Behavioral Economics to Implement Nutrition Ranking in Food Pantries
Status: NOT_YET_RECRUITING
Conditions: Food Insecurity|Dietary Quality|Behavioral Economics|Implementation Science
Interventions: BEHAVIORAL: Behavioral economics-enhanced user interface
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Studies of Application of Combined General Anesthesia and Bilateral TPVB in OPCABG
Status: UNKNOWN
Conditions: Coronary Heart Disease
Interventions: PROCEDURE: bilateral thoracic paravertebral block|DEVICE: Transesophageal Echocardiography（TEE）|DEVICE: Lung protection measure during the surgery（Dräger Primus）|DRUG: Anesthesia drugs during the surgery|PROCEDURE: thoracic paravertebral block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Incisionless Treatment for Patients With Inadequate Weight Loss Following Roux-en-Y Gastric Bypass
Status: TERMINATED
Conditions: Obesity
Interventions: DEVICE: Transoral Suturing|OTHER: Sham Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Krill Oil for Pain in Elders (KOPE)
Status: NOT_YET_RECRUITING
Conditions: Chronic Musculoskeletal Pain
Interventions: DRUG: Krill oil|DIETARY_SUPPLEMENT: Mixed vegetable oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT