pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Acute Comfort and Haze Profile of FID 114657
Status: COMPLETED
Conditions: Dry Eye
Interventions: OTHER: FID 114657 ORB Preserved Ocular Emulsion|OTHER: Soothe XP Lubricant Eye Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the NVT ALLEGRA Plus THV System in Patients With Severe Aortic Stenosis or Failed Surgical Aortic Bioprosthesis
Status: RECRUITING
Conditions: Transcatheter Aortic Valve Implantation
Interventions: DEVICE: (ALLEGRA Plus Transcatheter Heart Valve) TAVI in severe calcified aortic stenosis or in failed surgical aortic bioprosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Whole Grain, Gluten-containing Cereal and PROBIOtics to Evaluate Digestive TOLERAance and Immuno-inflammatory Response
Status: UNKNOWN
Conditions: Gastrointestinal Disorder|Immunologic Diseases in Children
Interventions: DIETARY_SUPPLEMENT: Experimental cereal|DIETARY_SUPPLEMENT: Conventional cereal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinical Study to Investigate the Effects of a Food Supplement Santa Herba Extract on Weight Loss in Overweight Women
Status: COMPLETED
Conditions: Weight Loss
Interventions: DIETARY_SUPPLEMENT: Santa herba|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison Between Stereotactic Aspiration and Intra-endoscopic Surgery to Treat Intracerebral Hemorrhage
Status: UNKNOWN
Conditions: Intracerebral Hemorrhage|Surgery
Interventions: PROCEDURE: Intra-endoscopic surgery|PROCEDURE: Placebo:stereotactic aspiration surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fiber-reinforced Composite Core Filling in the Restoration of Endodontically Treated Molars - a Clinical Study.
Status: COMPLETED
Conditions: Dental Materials|Tooth, Nonvital
Interventions: PROCEDURE: local anesthesia|PROCEDURE: Tooth restored using SFRC filling|PROCEDURE: Tooth restored using Ceramic indirect endocrown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alveolar Ridge Preservation Following Tooth Extraction Using Advanced Platelet Rich Fibrin (A-PRF) Versus Platelet Rich Fibrin (PRF)
Status: UNKNOWN
Conditions: Alveolar Bone Resorption
Interventions: PROCEDURE: Platelet rich fibrin (PRF)|PROCEDURE: Advanced platelet rich fibrin (A-PRF)|PROCEDURE: blood clot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Physiopathology of Lower Cortical Activation in COPD Patients: Contribution of Cortical Neuromodulation
Status: COMPLETED
Conditions: Physiology
Interventions: DEVICE: Anodal transcranial direct-current-stimulation|DEVICE: Sham transcranial direct-current-stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Internet-based ERITA Added to TAU in Young People With Non-Suicidal Self-Injury (TEENS) Feasibility Trial
Status: COMPLETED
Conditions: Non-suicidal Self-injury
Interventions: BEHAVIORAL: Internet-based Emotion Regulation Individual Therapy for Adolescents (ERITA-DK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of TXA127 in Post-ischemic Stroke Patients
Status: RECRUITING
Conditions: Ischemic Stroke
Interventions: DRUG: talfirastide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of ABP 215 Compared With Bevacizumab in Patients With Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer Metastatic
Interventions: DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: ABP 215|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CORETOX® in Treatment of Post Stroke Upper Limb Spasticity (Phase1)
Status: COMPLETED
Conditions: Muscle Spasticity
Interventions: DRUG: CORETOX®|DRUG: BOTOX®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interest of Immersive Virtual Reality on Stress During Botulinum Toxin Injections in Spasticity (RVTOX)
Status: ACTIVE_NOT_RECRUITING
Conditions: Central Neurogical Impairment
Interventions: DEVICE: DEEPSEN virtual reality mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Shared Healthcare Actions and Reflections Electronic Systems in Survivorship
Status: COMPLETED
Conditions: Cancer|Survivorship|Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: BEHAVIORAL: SHARE-S Implementation Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The BreaD Study - Bio-availability of D2 Vitamin Present in Bread
Status: COMPLETED
Conditions: Serum 25-hydroxyvitamin D Concentrations (25OHD)
Interventions: DIETARY_SUPPLEMENT: Vitamin D2|DIETARY_SUPPLEMENT: Vitamin D3|OTHER: Vitamin D2 fortified bread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Tecemotide (L-BLP25) in Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: BIOLOGICAL: Tecemotide (L-BLP25)|DRUG: cyclophosphamide (CPA)|OTHER: Chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Evaluation of Levosimendan in Patients With PH-HFpEF
Status: COMPLETED
Conditions: Hypertension Pulmonary Secondary|Heart Failure, Right Sided|Heart Failure With Normal Ejection Fraction
Interventions: DRUG: Levosimendan|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lyrica Dose Response Study With Restless Legs Syndrome (RLS) Patients
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DRUG: placebo|DRUG: Pregabalin|DRUG: Pregabalin|DRUG: Pregabalin|DRUG: Pregabalin|DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial for Inactivated Vaccine(Vero Cell) Against EV71 in Chinese Healthy Young Adults and Children
Status: COMPLETED
Conditions: Hand, Foot and Mouth Disease
Interventions: BIOLOGICAL: vaccine against EV71 of 320U/0.5ml|BIOLOGICAL: vaccine against EV71 of 640U/0.5ml|BIOLOGICAL: vaccine against EV71 of 160U/0.5ml|BIOLOGICAL: vaccine against EV71 of 320U/0.5ml|BIOLOGICAL: vaccine against EV71 of 640U/0.5ml
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: EvaLuate EndoVascular Treatment of Acutely Ruptured Shallow Intradural Aneurysms with the Pipeline™ Flex Embolization Device with Shield TEchnology™ (ELEVATE)
Status: RECRUITING
Conditions: Intracranial Aneurysm|Ruptured Aneurysm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Epoetin Alfa for Patients Having Abdominal or Pelvic Surgery for Cancer
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Epoetin Alfa group|OTHER: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Carboplatin and Gemcitabine With Bevacizumab Every 2 Weeks for Stage IIIb/IV Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Gemcitabine, Carboplatin, Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Malignant Mesothelioma
Status: COMPLETED
Conditions: Advanced Malignant Mesothelioma|Epithelial Mesothelioma|Localized Malignant Mesothelioma|Recurrent Malignant Mesothelioma|Sarcomatous Mesothelioma
Interventions: DRUG: gemcitabine hydrochloride|DRUG: cisplatin|BIOLOGICAL: bevacizumab|OTHER: placebo|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Bilingual Breast Cancer Educational Intervention for Hispanic Women With Stage I, Stage II, or Stage III Breast Cancer and Their Families or Caregivers
Status: COMPLETED
Conditions: Breast Cancer|Ductal Breast Carcinoma in Situ|Stage I Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: OTHER: educational intervention|PROCEDURE: quality-of-life assessment|OTHER: Questionnaire Administration|OTHER: psychosocial support for caregiver|PROCEDURE: assessment of therapy complications|OTHER: informational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Single Dose Bioequivalence Study Comparing Nifedipine/Candesartan FDC (Fixed Dose Combination) With Loose Combination of Nifedipine GITS (Gastro-intestinal Therapeutic System) Plus Candesartan and Single Components Under Fasting Conditions
Status: COMPLETED
Conditions: Hypertension, Essential
Interventions: DRUG: Nifedipine-candesartan FDC (BAY 98-7106)|DRUG: Nifedipine GITS (Adalat LA, BAYA1040)|DRUG: Candesartan (Atacand)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact on PCT+ FilmArray RP2 Plus Use in LRTI Suspicion in Emergency Department
Status: UNKNOWN
Conditions: Respiratory Tract Infections
Interventions: DIAGNOSTIC_TEST: Film Array RP2 Assay guided
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of BL-B01D1, SI-B003 and BL-B01D1+SI-B003 in Patients With Recurrent or Metastatic Cervical Cancer and Other Gynecological Malignancies
Status: RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: BL-B01D1|DRUG: SI-B003
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Vascular Findings Between Symptomatic and Asymptomatic Postmenopausal Women Before and During Hormone Therapy (HRT)
Status: COMPLETED
Conditions: Postmenopausal Vasomotor Symptoms|Cardiovascular Disease
Interventions: DRUG: 17-b-estradiol|DRUG: 17-b-estradiol + medroxyprogeterone acetate|DRUG: 17-b-estradiol hemihydrate|DRUG: placebo pill + gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exploration by NMR Spectroscopy of the Choline Concentrations in the Insular Cortex of Patients Suffering of Neuropathic Pain Induced by Oxaliplatin
Status: COMPLETED
Conditions: Neuropathy|Painful
Interventions: PROCEDURE: NMR Spectroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessment of Pruritus Improvement With Pimecrolimus Treatment on the Areas Affected by Mild-to-moderate AD, in Patients 2- to 11- Year-old
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Pimecrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Quality of Life and Safety Study With Pimecrolimus Cream, 1% in Children (Age 2-12 Years) With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Eczema
Interventions: DRUG: Pimecrolimus cream 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Followed by Surgery and Radiation Therapy With or Without Stem Cell Transplant in Treating Patients With Relapsed or Refractory Wilms' Tumor or Clear Cell Sarcoma of the Kidney
Status: UNKNOWN
Conditions: Kidney Cancer
Interventions: BIOLOGICAL: dactinomycin|DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: melphalan|DRUG: vincristine sulfate|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: conventional surgery|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Association of Anti-factor Xa Activity With Venous Thromboembolism in Critically Ill Patients
Status: RECRUITING
Conditions: Thrombosis|Pulmonary Embolism|Enoxaparin
Interventions: DIAGNOSTIC_TEST: Anti-factor Xa activity calibrated for enoxaparin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Nijmegen-Leiden-Amsterdam 2-tiered Care Path Study
Status: RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: DIAGNOSTIC_TEST: FIB4-score|DIAGNOSTIC_TEST: Vibration controlled transient elastography|DIAGNOSTIC_TEST: Enhanced Liver Fibrosis test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Airway Pressure and Lumen Changes During NIV With Flexible Bronchoscopy
Status: COMPLETED
Conditions: Airway Disease
Interventions: PROCEDURE: NIV rate: 0/min|PROCEDURE: NIV rate: 10-20/min|PROCEDURE: NIV rate: 5-10/min
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Develop a Novel Occupational Training Program for Schizophrenia Patients Based on Virtual Reality Techniques
Status: RECRUITING
Conditions: Schizophrenia|Cognitive Impairment
Interventions: BEHAVIORAL: VR-assisted occupational training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of HIV/STD Risk Reduction Program on South African Adolescents
Status: COMPLETED
Conditions: HIV Infections|Sexually Transmitted Disease
Interventions: BEHAVIORAL: HIV/STD Risk-Reduction|BEHAVIORAL: Health Promotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Study of Pharmacokinetics, Pharmacodynamics, Safety, and Immunogenicity of Single Intravenous Doses of BCD-148 and Soliris®
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: BIOLOGICAL: BCD-148|BIOLOGICAL: Soliris
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of VAY736 in Rheumatoid Arthritis Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: VAY736|BIOLOGICAL: VAY736 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: STROKESTOP III - Optimized Method for Atrial Fibrillation Screening
Status: RECRUITING
Conditions: Atrial Fibrillation|Atrial Fibrillation New Onset
Interventions: BEHAVIORAL: Screening invitation mode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: SCREENING AND SEROEPIDEMIOLOGY OF SARS-CoV-2 INFECTION AT THE UNIVERSITY OF BARCELONA: A CROSS-SECTIONAL STUDY
Status: COMPLETED
Conditions: SARS-CoV-2 Infection
Interventions: DIAGNOSTIC_TEST: SARS-CoV-2 PCR and serology tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Epinephrine Infusion for Prophylaxis Against Maternal Hypotension During Cesarean Delivery
Status: UNKNOWN
Conditions: Postspinal Hypotension|Cesarean Delivery|Epinephrine
Interventions: DRUG: Epinephrine 0.03|DRUG: Epinephrin 0.02|DRUG: Epinephrin 0.01
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Intranasal Oxytocin on Striatal Functional Connectivity
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxytocin|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Antecubital Versus Femoral Approach for Adrenal Venous Sampling
Status: RECRUITING
Conditions: Hyperaldosteronism
Interventions: PROCEDURE: Adrenal Venous Sampling via Antecubital Approach|PROCEDURE: Adrenal Venous Sampling via Femoral Approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial to Assess the Safety and Effects of Vorapaxar in Japanese Subjects With Acute Coronary Syndrome (P04772; MK-5348-016)
Status: COMPLETED
Conditions: Atherosclerosis|Myocardial Ischemia|Myocardial Infarction
Interventions: DRUG: Vorapaxar|DRUG: Placebo|DRUG: Aspirin|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-thymocyte Globulins for Graft-versus-host Disease Prophylaxis
Status: COMPLETED
Conditions: Leukemia, GVHD, ATG, Transplantation
Interventions: DRUG: anti thymoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Subjects' Satisfaction on Pan Facial Aesthetic Enhancement After Treatment With Azzalure® and the Restylane® Range
Status: COMPLETED
Conditions: Aging
Interventions: DRUG: Botulinum Toxin Type A (Azzalure)|DEVICE: Restylane ranges
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Imaging of Unstable Carotid Plaque in Patient Referred to Endarterectomy
Status: UNKNOWN
Conditions: Carotid Artery Stenosis
Interventions: DRUG: Sodium fluoride F-18 PET imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Assess the Safety and Tolerability of MEDI5117 in Rheumatoid Arthritis Patients
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: MEDI5117|BIOLOGICAL: MEDI5117 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cryobiopsy Versus Forceps Biopsy for Pulmonary Lesions
Status: TERMINATED
Conditions: Solitary Pulmonary Nodule|Multiple Pulmonary Nodules
Interventions: PROCEDURE: transbronchial biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Strawberry Consumption in Overweight and Obese Individuals
Status: UNKNOWN
Conditions: Obesity|Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Active strawberry powder|DIETARY_SUPPLEMENT: Placebo strawberry powder|DIETARY_SUPPLEMENT: Mixed strawberry powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Interaction of Tunodafil Hydrochloride Tablets and Alcohol
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Tunodafil Hydrochloride Tablets|DRUG: Placebo|OTHER: Alcohol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of An Oral Absorbent AST-120 in Late-stage Chronic Kidney Disease (CKD) Patients.
Status: COMPLETED
Conditions: Chronic Kidney Disease|AST-120
Interventions: DRUG: AST-120
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stress Ulcer Prophylaxis Versus Placebo in Critically Ill Infants With Congenital Heart Disease
Status: COMPLETED
Conditions: Congenital Heart Disease|Upper Gastrointestinal Bleeding|Stress Ulcer|Infection
Interventions: DRUG: Famotidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The His Optimised Pacing Evaluated for Heart Failure Trial (HOPE-HF).
Status: COMPLETED
Conditions: Heart Failure
Interventions: DEVICE: Pacemaker: AV optimised, His pacing.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RDD1609 as a Treatment for Idiopathic Pruritus Ani
Status: WITHDRAWN
Conditions: Idiopathic Pruritus Ani
Interventions: DRUG: RDD1609|DRUG: Mebendazole 100 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phamacokinetics and Safety Profiles of DA-1229_01 5/1000mg in Healthy Subjects at Fasting State
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DRUG: DA-1229_01 5/1000mg (Before)|DRUG: DA-1229_01 5/1000mg (After)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Stress Ball on Perceived Stress, Pain and Satisfaction in Cancer Patients
Status: ENROLLING_BY_INVITATION
Conditions: Cancer
Interventions: BEHAVIORAL: stress ball
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Task Oriented Training and Xbox KinectTM on Hand Function in Pediatric Burn
Status: COMPLETED
Conditions: Burns|Hand Burn
Interventions: OTHER: control|OTHER: Xbox kinect|OTHER: task oriented training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Single Ascending Dose and Multiple Ascending Doses of Oral AFA-281 in Healthy Volunteers
Status: RECRUITING
Conditions: Pain, Neuropathic|Pain, Inflammatory
Interventions: DRUG: AFA-281
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transversus Abdominis Plane Block for Postoperative Analgesia in Living Donor Hepatectomy
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: Transversus Abdominis Plane Block|DRUG: standard general anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Severe Obesity: Bariatric Surgery vs. Life-Style-Intervention
Status: COMPLETED
Conditions: Obesity|Cardiac Function|Quality of Life
Interventions: PROCEDURE: Roux-en-Y gastric bypass|BEHAVIORAL: Psychotherapy-enhanced lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib and Antiviral Therapy Followed By Effusion Drainage, Bevacizumab, and Combination Chemotherapy in Treating Patients With Primary Effusion Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: bevacizumab|BIOLOGICAL: filgrastim|BIOLOGICAL: pegfilgrastim|DRUG: bortezomib|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ganciclovir|DRUG: valganciclovir|DRUG: zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of RMC-035 in Subjects at High Risk for Acute Kidney Injury Following Open-Chest Cardiac Surgery
Status: TERMINATED
Conditions: Acute Kidney Injury
Interventions: DRUG: RMC-035|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Aspirin and Plavix Following Coronary Artery Bypass Grafting
Status: TERMINATED
Conditions: Coronary Graft Patency
Interventions: DRUG: clopidogrel|DRUG: sugar pill|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Transcutaneous Electrical Nerve Stimulation on CIPN Symptoms
Status: COMPLETED
Conditions: Chemotherapy-induced Peripheral Neuropathy
Interventions: DEVICE: Transcutaneous electrical nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Various Cooking Oils on Health Related Biomarkers in Healthy Subjects
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: OTHER: Fat-free milkshake|OTHER: Olive oil|OTHER: Soybean oil|OTHER: Fried soybean oil|OTHER: Palm oil|OTHER: Fried palm oil|OTHER: Camellia oil|OTHER: Fried camellia oil|OTHER: Tallow|OTHER: Fried tallow
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Remote Cognitive Remediation for Depression
Status: UNKNOWN
Conditions: Major Depression
Interventions: BEHAVIORAL: Active Cognitive Remediation|BEHAVIORAL: Cognitive Remediation Control|BEHAVIORAL: Online computer exercises|BEHAVIORAL: Strategy monitoring|BEHAVIORAL: Bridging strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of BGG492 in the Treatment of Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: BGG492|DRUG: Sumatriptan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quantitative Polymerase Chain Reaction for Improved Detection of Pneumococci in CAP "CAPTAIN"
Status: COMPLETED
Conditions: Pneumonia, Pneumococcal|Community-acquired Pneumonia
Interventions: DIAGNOSTIC_TEST: LytA targeted quantitative polymerase chain reaction (qPCR)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: European, Open-label, Prospective, Multinational, Multicenter Study in Adult Subjects With Type 1 or Type 2 Diabetes Previously on MDI or CSII Therapy. Subjects Home Setting is Considered Routine Practice.
Status: COMPLETED
Conditions: Type 2 Diabetes, Type 1 Diabetes
Interventions: DEVICE: Accu-Chek® Insight Insulin Pump
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Metabolic and Vascular Effects of Statins in Untreated Dyslipidemic Diabetic Patients
Status: COMPLETED
Conditions: Type 2 Diabetes|Diabetic Dyslipidemia
Interventions: DRUG: Simvastatin|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Cardiac Resynchronization Therapy With Defibrillation
Status: COMPLETED
Conditions: Heart Failure, Congestive|Ventricular Fibrillation|Tachycardia, Ventricular
Interventions: DEVICE: Cardiac Resynchronization Therapy with Defibrillation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Dose-Ranging Study of Pradefovir in Patients With Compensated Hepatitis B
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: pradefovir mesylate|DRUG: adefovir dipivoxyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imaging Neuroinflammation in Epilepsy With Ferumoxytol MRI
Status: COMPLETED
Conditions: Epilepsy
Interventions: OTHER: Ferumoxytol injection after focal epileptic seizure followed by iron-sensitive MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Intravenous Telisotuzumab Vedotin in Combination Osimertinib or Standard of Care Chemotherapy to Assess Change in Disease Activity in Adult Participants With Non-Small Cell Lung Cancer That Has a Mutation in the Epidermal Growth Factor Receptor Gene and That Overexpresses the c-Met Protein
Status: WITHDRAWN
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Telisotuzumab Vedotin|DRUG: Osimertinib|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Abuse Liability, Pharmacokinetics, Safety and Tolerability of an Abuse-Deterrent d-Amphetamine Sulfate Immediate Release Formulation (ADAIR)
Status: COMPLETED
Conditions: ADHD|Narcolepsy
Interventions: DRUG: ADAIR 10 mg IR tablets|DRUG: d-amphetamine sulfate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Repaglinide Combined With Insulin in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: repaglinide|DRUG: isophane human insulin|DRUG: insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer (NSCLC), Head and Neck Squamous Cell Carcinoma (HNSCC) and Other Solid Tumors, Receiving Intravenous (IV) Infusion of ABBV-514 Alone or in Combination With Budigalimab
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: ABBV-514|DRUG: Budigalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Acetic Acid Chromoendoscopy in Barrett's Esophagus Surveillance
Status: TERMINATED
Conditions: Barrett's Esophagus
Interventions: DRUG: Chromoendoscopy using Acetic Acid 2.5%|OTHER: Standard random esophageal biopsies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Chloroquine Associated With Dehydroepiandrosterone Sulphate to Treat Uncomplicated Falciparum Malaria
Status: SUSPENDED
Conditions: Malaria
Interventions: DRUG: chloroquine|DRUG: dehydroepiandrosterone sulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)
Status: RECRUITING
Conditions: B-cell Acute Lymphoblastic Leukemia|Diffuse Large B-cell Lymphoma|Burkitt Lymphoma|Neuroblastoma|Ewing Sarcoma
Interventions: BIOLOGICAL: Zilovertamab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tocilizumab Added to DMARDs in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to DMARDs.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: tocilizumab [RoActemra/Actemra]|DRUG: DMARDs (disease-modifying antirheumatic drugs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Use of Rigid Fixation After Removing Distraction Osteogenesis Device Reduce the Relapse?
Status: COMPLETED
Conditions: Cleft Palate|Maxillary Hypoplasia|Maxillary Retrognathism
Interventions: DEVICE: mini plate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Periprocedural Continuation Versus Interruption of Oral Anticoagulant Drugs During Transcatheter Aortic Valve Implantation (POPular PAUSE TAVI)
Status: COMPLETED
Conditions: Aortic Valve Disease|Aortic Valve Stenosis|Stroke|Bleeding|Vascular Complications|Myocardial Infarction|Thrombosis Embolism
Interventions: DRUG: Continuation of oral anticoagulants|DRUG: Interruption of oral anticoagulants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Doubling the Iron Dose to Prevent IDA in Twin Pregnant Women
Status: COMPLETED
Conditions: Hematologic Pregnancy Complications
Interventions: DRUG: Feroglobin single daily use|DRUG: Feroglobin twice daily dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Kinesio Taping Application in Women With Overactive Bladder
Status: UNKNOWN
Conditions: Overactive Bladder Syndrome
Interventions: OTHER: Kinesio tape application|OTHER: Sham tape application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Tolerability Study of ARGX-113 in Patients With Myasthenia Gravis Who Have Generalized Muscle Weakness.
Status: COMPLETED
Conditions: Generalized Myasthenia Gravis
Interventions: BIOLOGICAL: ARGX-113
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Clinical Trial to Evaluate the Effects of Atorvastatin on Graves' Orbitopathy (GO): the STAGO-2 Study
Status: NOT_YET_RECRUITING
Conditions: Graves' Orbitopathy
Interventions: DRUG: Atorvastatin 20mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Help-Seeking Stigma in Young Adults at Elevated Suicide Risk
Status: COMPLETED
Conditions: Suicide|Help-Seeking Behavior|Health Behavior
Interventions: BEHAVIORAL: Cognitive Bias Modification|BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety, Tolerability, Pharmacokinetics, and Activity of GS-9450 in Subjects With Chronic HCV
Status: COMPLETED
Conditions: HCV Infection
Interventions: DRUG: GS-9450|DRUG: GS-9450 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: the Effective Bolus Dose of Remifentanil for Laryngeal Mask Airway (LMA) Insertion in Children
Status: COMPLETED
Conditions: Respiratory Complication
Interventions: DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Reflexology on Diabetic Foot and Glycemic Control in Elderly Diabetic Individuals
Status: COMPLETED
Conditions: Reflexology|Type 2 Diabetes|Older People
Interventions: OTHER: Foot reflexology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prevention of Colon Ischemia During Aortic Aneurysm (AAA) Repair
Status: COMPLETED
Conditions: Colon Ischemia|Aortic Aneurysm
Interventions: PROCEDURE: Reestablish colon blood flow
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Stem Cells for Cardiac Angiogenesis (FOCUS HF)
Status: COMPLETED
Conditions: Ischemic Cardiomyopathy
Interventions: DEVICE: Intramyocardial Injection of stem cells via NOGA Mapping|OTHER: Control, then Stem Cell Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Open-label, Non-randomized, Parallel Group Study in Subjects With Mild and Moderate Hepatic Insufficiency and Healthy Volunteers
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: Ferriprox®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: A Trial Comparing Docetaxel 75 mg/m2 (3w) Versus Docetaxel 50 mg/m2 (2w) in Combination With Darolutamide + ADT in mHSPC Patients
Status: RECRUITING
Conditions: Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
Interventions: DRUG: Standard ADT (androgen deprivation therapy)|DRUG: Standard Darolutamide|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cutting Balloon Predilation Prior to Abluminus Sirolimus-eluting Stent Implantation (CUT-DRESS).
Status: RECRUITING
Conditions: Coronary Artery Disease|Percutaneous Coronary Intervention|Cutting Balloon
Interventions: DEVICE: Predilation with cutting balloon.|DEVICE: Predilation with conventional balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of PaCO2 Levels on Cerebral Metabolism and Perfusion During Induced Hypothermia.
Status: COMPLETED
Conditions: Cerebral Metabolism and Perfusion
Interventions: OTHER: mild hypo- and hyperventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Q Value Customized Versus Wavefront Optimized Ablation in Femtosecond Laser-Assisted LASIK
Status: COMPLETED
Conditions: Patients With Myopic Spherical Equivalent up to -12 Diopters
Interventions: PROCEDURE: Femtosecond laser assisted LASIK eye surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nuclear Imaging of Human CSF Flow Using Ga-67 Citrate and In-111 DTPA
Status: TERMINATED
Conditions: Central Nervous System Tumors|Brain Tumors
Interventions: DRUG: Gallium-67 Citrate (Ga-67)|DRUG: In-111 DTPA (In-111 pentetate)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicentre Blinded Comparison of Lyophilized Sterile Fecal Filtrate to Lyophilized Fecal Microbiota Transplant in Recurrent Clostridioides Difficile Infection
Status: COMPLETED
Conditions: Clostridia Difficile Colitis|Clostridium Difficile Diarrhea
Interventions: BIOLOGICAL: Lyophilized fecal microbiota transplant|BIOLOGICAL: Lyophilized sterile fecal filtrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men to Test How BI 1015550 is Taken up and Handled by the Body
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1015550|DRUG: BI 1015550 mixed with [C-14]-BI 1015550
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Misoprostol and Prostaglandin E2 (PGE2) Gel for Induction of Labour in Premature Rupture of Membranes at Term
Status: COMPLETED
Conditions: Premature Rupture of Membranes at Term
Interventions: DRUG: Misoprostol|DRUG: PGE2 gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on the Anti-incontinent Effectiveness of the mTVM Method in POPQ Stage II-III Patients
Status: UNKNOWN
Conditions: Uterine Prolapse|Urinary Stress Incontinence|Side Effects
Interventions: PROCEDURE: Trans-vaginal Mesh operation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Heat Killed Probiotics in the Prevention of Necrotizing Enterocolitis
Status: UNKNOWN
Conditions: Necrotizing Enterocolitis|Enterocolitis, Necrotizing
Interventions: DIETARY_SUPPLEMENT: Heat Inactivated probiotics|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Comparison Study of the Perclose Proglide (TM) SMC System Versus Figure-of-8- Suture Technique for Closure of Large-bore Femoral Venous Access.
Status: RECRUITING
Conditions: Cardiovascular Diseases
Interventions: OTHER: Closure Strategy with Perclose-Proglide system|OTHER: Closure Strategy with figure-of-8
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Tolerability, and Pharmacokinetics of a Subcutaneous and Intravenous Dose of BI 655130 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 655130
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Novel Pancreaticojejunostomy Technique for Pancreaticoduodenectomy
Status: COMPLETED
Conditions: Pancreatic Fistula
Interventions: PROCEDURE: Pancreaticojejunostomy technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effect of MK-8457 on Blood Pressure in Hypertensive Participants (MK-8457-004-AM1)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: MK-8457|DRUG: Placebo for MK-8457
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ductal Lavage Versus Corticosteroids Therapy for Idiopathic Granulomatous Mastitis
Status: COMPLETED
Conditions: Granulomatous Mastitis
Interventions: PROCEDURE: Ductal lavage|DRUG: Corticosteroid therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Transcranial Magnetic Stimulation Decrease Food Reinforcement
Status: RECRUITING
Conditions: Obesity
Interventions: DEVICE: TMS followed by sham TMS|DEVICE: Sham TMS followed by TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Measures of Plasticity
Status: COMPLETED
Conditions: Depression|Healthy
Interventions: PROCEDURE: cTBS-PAS25|PROCEDURE: cTBS-iTBS|PROCEDURE: PAS25|PROCEDURE: iTBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Influence of Glucagon Inhibition in Relation to the Anti-Diabetic Effect of Glucagon-Like Peptide-1 (GLP-1) in Patients With Type 2 Diabetes Mellitus
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: Infusion of native hormones from the pancreas and gut (GLP-1)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Efficacy and Safety of SAGE-217 in Participants With Severe Postpartum Depression (PPD)
Status: COMPLETED
Conditions: Depression, Postpartum
Interventions: DRUG: SAGE-217|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Static Implant Versus Dynamic Implant in the Surgical Treatment on Ankle Syndesmosis Rupture
Status: COMPLETED
Conditions: Ankle Syndesmosis Rupture
Interventions: PROCEDURE: TightRope System- Arthrex® / Dynamic Implant|PROCEDURE: Screw fixation - Synthes® / Static Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT