pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Brown Seaweed as a Breast Cancer Preventive
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DIETARY_SUPPLEMENT: Seaweed and Soy Protein|DIETARY_SUPPLEMENT: Placebo and Soy Protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Radiotherapy Combined With Toripalimab for Locally Advanced Head and Neck Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Toripalimab|RADIATION: Stereotactic Body Radiation Therapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Low Versus High Carbohydrate Diet During Rehabilitation on Cardiovascular Function and Metabolism in Type 2 Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus|Overweight
Interventions: OTHER: LOGI diet|OTHER: Low Fat diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does eNOS Gene Polymorphism Play a Role in the Maintenance of Basal Vascular Tone in the Choroid or Optic Nerve Head?
Status: TERMINATED
Conditions: Ocular Physiology|Regional Blood Flow
Interventions: DRUG: NG-monomethyl-L-arginine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Compare Two Dosing Regimens for a New Malaria Vaccine
Status: RECRUITING
Conditions: Malaria|Malaria,Falciparum|Protozoan Infections|Parasitic Disease|Infections|Vector Borne Diseases
Interventions: BIOLOGICAL: Matrix M with RH5.1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Isolation of Volatile Organic Compounds (VOCs) Related to the Olfactory Signature of Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Surgery
Interventions: DIAGNOSTIC_TEST: Sorbstar®|DIAGNOSTIC_TEST: Odour sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Megadose CD34 Selected Progenitor Cells for Transplantation in Patients With Advanced Hematological Malignant Diseases
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: PROCEDURE: Megadose of CD34 Selected Progenitor Cells|DRUG: Melphalan|DRUG: Thiotepa|DRUG: Fludarabine|DRUG: Rabbit ATG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azacytidine and Lymphocytes in Relapse of AML or MDS After Allogeneic Stem Cell Transplantation.
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Myelodysplastic Syndrome
Interventions: BIOLOGICAL: Donor lymphocyte infusion|DRUG: Azacytidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Follow-up Study of Safety and Efficacy in Subjects Who Completed PNEUMOSTEM® Phase II (MP-CR-012) Clinical Trial
Status: RECRUITING
Conditions: Bronchopulmonary Dysplasia
Interventions: BIOLOGICAL: PNEUMOSTEM®|BIOLOGICAL: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Blended Oil Beneficial for Blood Lipids Management
Status: UNKNOWN
Conditions: Hyperlipidemias
Interventions: OTHER: Refined olive oil (ROO)|OTHER: Blended Oil 1 (BO1)|OTHER: Blended Oil 2 (BO2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison of Different Video Laryngoscopes in < 1 Year Old Undergoing Neurosurgical Operations: a Prospective Randomized Study
Status: COMPLETED
Conditions: Intubation;Difficult
Interventions: DEVICE: airtraq|DEVICE: c-mac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of 2 Diet Plans Designed for People With Type II Diabetes on Weight and Health Measures
Status: COMPLETED
Conditions: Obesity|Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Medifast Plus for Diabetics Meal Replacement Supplements|BEHAVIORAL: Standard ADA recommended diet for type 2 diabetics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Health Facility Networking for Maternal Health
Status: COMPLETED
Conditions: Provider Skill|Provider Confidence|Maternal Health|Referral Systems
Interventions: OTHER: Training of health workers in Basic Obstetric Emergency Care|OTHER: Hospital-health center networking system|OTHER: Post Basic Emergency Obstetric Training Mentorship|OTHER: Team-Based Supportive supervision|OTHER: Midwives exchange program|OTHER: Strengthening the referral network|OTHER: Facility Checklists|OTHER: Emergency Drills
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: 131I-omburtamab Delivered by Convection-Enhanced Delivery in Patients With Diffuse Intrinsic Pontine Glioma
Status: WITHDRAWN
Conditions: DIPG
Interventions: DRUG: 131I-Omburtamab|DEVICE: Convention Enhanced Delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bifocal & Atropine in Myopia (BAM) Study
Status: COMPLETED
Conditions: Refractive Errors
Interventions: COMBINATION_PRODUCT: Multifocal D +2.50 add & 0.01% atropine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy/Safety of Vildagliptin and Metformin Combination Therapy in Patients With Type 2 Diabetes Not Well Controlled With Metformin Alone
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Vildagliptin|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Propranolol for Reducing Pediatric Dental Patients Anxiety
Status: COMPLETED
Conditions: Extrusion of Tooth
Interventions: DRUG: Propranolol|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Atomoxetine Treatment of Adults With ADHD and Comorbid Alcohol Abuse
Status: COMPLETED
Conditions: ADHD|Comorbid Alcohol Abuse
Interventions: DRUG: Atomoxetine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation in Pediatrics. Oral or Parenteral! D2 or D3
Status: NOT_YET_RECRUITING
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: vitamin D2, vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnifying Endoscopy With Narrow Band Imaging Versus Endoscopic Ultrasonography for Prediction of Tumor Invasion Depth in Early Gastric Cancer: A Prospective Comparative Study
Status: UNKNOWN
Conditions: Early Gastric Cancer|Gastric Adenoma|Gastric Dysplasia
Interventions: DEVICE: magnifying endoscopy with narrow band imaging (ME-NBI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Wireless EEG Patch for Continuous Electrographic Monitoring
Status: ENROLLING_BY_INVITATION
Conditions: Epilepsy
Interventions: DEVICE: Observational only|BEHAVIORAL: Psychological and Behavioral interaction with a seizure forecasting mobile app|COMBINATION_PRODUCT: Seizure Alerting and Prediction System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Nivolumab Plus Ipilimumab, Ipilimumab Alone, or Cabazitaxel in Men With Metastatic Castration-Resistant Prostate Cancer (CheckMate 650)
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: Ipilimumab|DRUG: Cabazitaxel|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Epidermal Growth Factor Receptor Inhibitor Therapy in the Skin of Cancer Patients
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: enzyme inhibitor therapy|GENETIC: protein expression analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|PROCEDURE: biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hepatosplenic CANdidiasis : PETscan and Immune Response Analysis
Status: COMPLETED
Conditions: Invasive Fungal Disease|Chronic Disseminated Candidiasis|Hematological Malignancies|Hematopoietic Stem Cell Transplantation|Neutropenia
Interventions: DEVICE: 18F-FDG PET Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Contrast-enhanced Ultrasound as a Screening Tool for Kidney Cancer in Patients With Von-Hippel Lindau
Status: COMPLETED
Conditions: Von-Hippel Lindau|Kidney Disease, Chronic
Interventions: DRUG: Perflutren lipid microsphere|DRUG: Sulfur hexafluoride lipid microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: JDQ443 for KRAS G12C NSCLC Brain Metastases
Status: WITHDRAWN
Conditions: Non Small Cell Lung Cancer Metastatic|Brain Metastases, Adult|KRAS G12C
Interventions: DRUG: JDQ443
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Evaluating Folic Acid Supplementation by Concomitant Administration of Ethinyl Estradiol + Levonorgestrel
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: ethinyl estradiol + levonorgestrel + folic acid|DRUG: Folic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bortezomib in Late Antibody-mediated Kidney Transplant Rejection
Status: COMPLETED
Conditions: Late Rejection of Renal Transplant|Antibody-mediated Rejection
Interventions: DRUG: Bortezomib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Serplulimab Plus Bevacizumab and Chemotherapy for EGFR-mutant Metastatic NSCLC Patients After EGFR-TKI Treatment Failure
Status: RECRUITING
Conditions: Non-Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: Serplulimab|DRUG: Bevacizumab Biosimilar HLX04|DRUG: Pemetrexed|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human CD19 Targeted T Cells Injection(CD19 CAR-T) Therapy for Relapsed and Refractory CD19-positive Lymphoma.
Status: UNKNOWN
Conditions: CD19-positive|Diffuse Large B-cell Lymphoma|Follicular Lymphoma
Interventions: DRUG: Human CD19 targeted T Cells Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Stydy of Bevacizumab Plus Erlotinib in Patients for Krebs Cycle Altered Cancer
Status: RECRUITING
Conditions: Solid Tumors|Advanced Solid Tumors|Metastatic Cancer
Interventions: DRUG: bevacizumab|DRUG: erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure
Status: RECRUITING
Conditions: Orthostatic Hypotension|Pure Autonomic Failure|Multiple System Atrophy|Autonomic Failure
Interventions: OTHER: Abdominal compression|OTHER: Sham abdominal compression|DRUG: Placebo pill|DRUG: midodrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: The Effect of Mandala Therapy on Anxiety and Comfort in Kidney Transplant Recipients
Status: RECRUITING
Conditions: Anxiety|Transplant;Failure,Kidney|Transplant Complication
Interventions: BEHAVIORAL: Mandala Art Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Platelet Rich Plasma in Healing of Through and Through Periradicular Lesions
Status: UNKNOWN
Conditions: Periapical Lesions
Interventions: PROCEDURE: PRP|PROCEDURE: periapical surgery without PRP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Predictors of Poor Treatment Response in Patients With Schizophrenia Treated With Atypical Antipsychotics
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Olanzapine|DRUG: risperidone|DRUG: Paliperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterising the Natural History of Mucosal Metabolism During Colorectal Anastomotic Healing
Status: RECRUITING
Conditions: Healing of Colorectal Anastomoses
Interventions: OTHER: Distal limb reintroduction of ileostomy effluent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Open-Label Evaluation of the Dose Proportionality of OROS� Hydromorphone HCL Tablets 8mg, 16mg, 32mg, 64mg
Status: COMPLETED
Conditions: Analgesia
Interventions: DRUG: OROS® Hydromorphone HCL; OROS® Dilaudid; Dilaudid SR (slow release); Naltrexone (an opioid antagonist).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Mycophenolate Mofetil 250 mg Capsule, Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Mycophenolate Mofetil|DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Evaluating the Safety of 2 Schedules of Cabazitaxel in Elderly Men With mCRPC Previously Treated With a Docetaxel
Status: COMPLETED
Conditions: Prostate Cancer Metastatic
Interventions: DRUG: cabazitaxel|DRUG: Prednisone|DRUG: Granulocyte colony-stimulating factor (G-CSF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coronaltitude - Multicentric Evaluation of the Impact on Hypoxia Sensitivity of Patients With COVID-19
Status: COMPLETED
Conditions: Covid19|SARS-CoV2 Infection|Hypoxia, Altitude
Interventions: BIOLOGICAL: COVID19
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: WAL 801 CL Dry Syrup in Paediatric Atopic Dermatitis Patients
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: WAL 801 CL Dry Syrup|DRUG: Ketotifen Fumarate Dry Syrup|DRUG: WAL 801 CL Dry Syrup placebo|DRUG: Ketotifen Fumarate Dry Syrup placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation in Primary Care: A Project to Maximize the Health Status of Adults With Chronic Illness
Status: COMPLETED
Conditions: Chronic Disease|Hypertension|Back Pain|Obesity|Arthritis
Interventions: BEHAVIORAL: Occupational therapy|BEHAVIORAL: Physiotherapy|BEHAVIORAL: Self-management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enriched Holistic Care to Eradicate Disparities in Maternal Morbidity
Status: RECRUITING
Conditions: Morbidity;Perinatal
Interventions: OTHER: Maternity care home model (MCHM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy Study of Sitaxentan Sodium (Thelin™) in Patients With Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: sitaxsentan sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Antineoplaston Therapy in Treating Patients With Brain Tumors
Status: COMPLETED
Conditions: Refractory Brain Tumors
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Randomized Study With R-DHAP +/- Bortezomib as Induction Therapy in Relapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL) Patients Eligible to Transplantation. BR-DHAP Versus R-DHAP.
Status: COMPLETED
Conditions: Diffuse Large B-cell Lymphoma Refractory|Diffuse Large B-cell Lymphoma Recurrent
Interventions: DRUG: R-DHAP|DRUG: BR-DHAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing a New Device to Advance the Use of Social Skills Training With Mental Health Consumers and Clinicians
Status: COMPLETED
Conditions: Schizophrenia Spectrum and Other Psychotic Disorders
Interventions: BEHAVIORAL: Social Skills Coach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Safety and Tolerability of the Combination of BI 207127 and Faldaprevir in Renal Impaired Patients
Status: TERMINATED
Conditions: Renal Insufficiency
Interventions: DRUG: BI 207127|DRUG: faldaprevir|DRUG: BI 207127|DRUG: BI 207127|DRUG: BI 207127|DRUG: faldaprevir|DRUG: faldaprevir|DRUG: faldaprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antiplaque/Antigingivitis Effect of Lacer Oros Integral
Status: COMPLETED
Conditions: Periodontitis|Dental Plaque|Gingival Inflammation
Interventions: OTHER: test mouth rinse (Lacer Oros Acción Integral - new formula, Barcelona, Spain).|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probenecid as Medication for Alcohol Use Disorder
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: DRUG: Probenecid|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ASP5094 Following Multiple Intravenous Doses in Subjects With Rheumatoid Arthritis on Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis (RA)
Interventions: DRUG: ASP5094|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Milk on Erosion/Abrasion of Enamel and Dentin - an in Situ Study
Status: COMPLETED
Conditions: Erosion Protection
Interventions: OTHER: Toothpaste|DIETARY_SUPPLEMENT: Milk|DIETARY_SUPPLEMENT: Fluoridated Milk|DRUG: Tooth Mousse|DRUG: MI Paste Plus|DRUG: Elmex Erosion Protection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Dietary Intake in Adults From the GA2LEN Folow-up Survey
Status: COMPLETED
Conditions: Asthma|Lung Function Decreased|Food Allergy|Allergic Sensitisation|Allergic Rhinitis|COPD|Atopy
Interventions: OTHER: Dietary intake of various nutrients, foods and biocompounds
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 1 Parallel-Group, Double-Blind, Placebo-Controlled Cardiovascular and Behavioral Study Assessing Interactions Between Single Doses of Oral Reserpine and Intravenous Methamphetamine - 1
Status: UNKNOWN
Conditions: Amphetamine-Related Disorders
Interventions: DRUG: Reserpine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Association of Apical Periodontitis With Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Periapical Lesions
Interventions: BIOLOGICAL: levels of CKD markers, Oral health status, apical periodontitis|BIOLOGICAL: systemic inflammatory marker, Oral health status, apical periodontitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Moderate vs Deep Neuromuscular Block in Lower Pressure Pneumoperitoneum
Status: COMPLETED
Conditions: Gynecologic Disease|Neuromuscular Blockade
Interventions: DRUG: Deep neuromuscular block using intravenous rocuronium induction at 1.2mg/kg and maintainance of 8-12mcg/kg/min for deep neuromuscular block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Reading Performance in Patients With Acrysof IQ Vivity Versus Acrysof IQ
Status: UNKNOWN
Conditions: Cataract
Interventions: DEVICE: enhanced depth of focus IOL|DEVICE: monofocal IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Treatment With Laparoscopic Fenestration or Aspiration Sclerotherapy for Large Symptomatic Hepatic Cysts
Status: RECRUITING
Conditions: Liver Cyst|Polycystic Liver Disease|Autosomal Dominant Polycystic Kidney|Autosomal Dominant Polycystic Liver Disease
Interventions: PROCEDURE: aspiration sclerotherapy versus laparoscopic fenestration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Complement Lectin Pathway After Cardiac Arrest
Status: UNKNOWN
Conditions: Out-of-Hospital Cardiac Arrest|Post Cardiac Arrest Syndrome
Interventions: OTHER: Targeted temperature management (33 degree Celsius)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Comparing Duloxetine to Other Antidepressants in the Treatment of Severe Depression
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: duloxetine|DRUG: fluoxetine|DRUG: citalopram|DRUG: paroxetine|DRUG: sertraline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Oxygen Supplementation in Training in Heart Failure Patients on Aerobic Performance and Quality of Life
Status: COMPLETED
Conditions: Heart Failure With Reduced Ejection Fraction|Heart Failure With Mid Range Ejection Fraction
Interventions: OTHER: train with oxygen and without oxygen enrichment (placebo).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Evaluation of an Educational Program in the Prevention of the Driving Risks in Patients With Neurocognitive Disorders : ACCOMPAGNE
Status: TERMINATED
Conditions: Driving Habits Patients|Cognitive Impairment
Interventions: BEHAVIORAL: ACCOMPAGNE Education Program|BEHAVIORAL: Usuals recommandations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Evaluation of Patients With Esophageal and Foregut Disorders With WATS (Wide Area Transepithelial Sample With 3-Dimensional Computer-Assisted Analysis) vs. 4-Quadrant Forceps Biopsy
Status: COMPLETED
Conditions: GERD|Barrett Esophagus|Low Grade Esophageal Glandular Dysplasia|Esophageal Diseases
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Radiotherapy With Pembrolizumab in Metastatic HNSCC
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: COMBINATION_PRODUCT: A (pembrolizumab+RT)|DRUG: B (pembrolizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy Using Precision T Cells Specific to Multiple Common Tumor-Associated Antigen Combined With Transcatheter Arterial Chemoembolization for the Treatment of Advanced Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Recurrence Hepatocellular Carcinoma|Advanced Hepatocellular Carcinoma
Interventions: PROCEDURE: TACE|BIOLOGICAL: Dendritic Cell|DRUG: lipiodol|DRUG: Mitomycin (MMC)|DRUG: Epirubicin(EADM)|BIOLOGICAL: Precision Multiple Antigen T Cell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metabolic Differences Between Dihydroberberine and Micellar Berberine
Status: COMPLETED
Conditions: Phase I and Phase II Metabolites of Berberine
Interventions: OTHER: LMB|OTHER: DHB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Mindhelper on Young People's Well-being, Psychological Functioning, and Intentions to Help-seeking
Status: NOT_YET_RECRUITING
Conditions: Mental Health Issue|Well-Being|Adolescents|Young Adults|Online Intervention|Internet-Based Intervention|Randomized Controlled Trial
Interventions: BEHAVIORAL: Mindhelper- A national youth mental health promotion website
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effect of Insulin Degludec Versus Insulin Glargine on Glycemic Variability in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Insulin Degludec|DRUG: Insulin Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Divalproex and Quetiapine in Elderly Alzheimer's Dementia Patients
Status: WITHDRAWN
Conditions: Alzheimer's Disease|Dementia|Behavioral Symptoms
Interventions: DRUG: Divalproex ER|DRUG: Quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blood Pressure Checks for Diagnosing Hypertension (BP-CHECK)
Status: COMPLETED
Conditions: Blood Pressure
Interventions: DIAGNOSTIC_TEST: Clinic Blood Pressure Measurement|DIAGNOSTIC_TEST: Home Blood Pressure Measurement|DIAGNOSTIC_TEST: Kiosk Blood Pressure Measurement|DIAGNOSTIC_TEST: 24-hour Ambulatory Blood Pressure Monitoring (Reference Standard)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: PelviSense, an Innovative, Non-invasive, Biofeedback Device for the Treatment of Stress Urinary Incontinence in Women
Status: RECRUITING
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: PelviSense-assisted pelvic floor muscle training|OTHER: Active Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of MT-0551 in Patients With Systemic Sclerosis
Status: RECRUITING
Conditions: Systemic Sclerosis
Interventions: DRUG: Inebilizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Exposures of Lofexidine and Its Major Metabolites in Subjects Seeking Buprenorphine Dose Reduction
Status: COMPLETED
Conditions: Substance Withdrawal Syndrome|Opiate Addiction|Opiate Dependence
Interventions: DRUG: lofexidine administration in subjects seeking buprenorphine dose reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of FOL-005 on Clinical Safety and Effect on Hair Growth
Status: COMPLETED
Conditions: Hypertrichosis|Alopecia|Hirsutism
Interventions: DRUG: FOL-005|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Chiglitazar Compare With Sitagliptin in Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Chiglitazar|DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of BGB-11417 in Adult Participants With Mature B-cell Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Mature B-cell Malignancies
Interventions: DRUG: BGB-11417
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thulium vs. Hol:YAG Laser
Status: COMPLETED
Conditions: Nephrolithiasis
Interventions: DEVICE: Thulium Fibre Laser|DEVICE: Holmium:Yttrium-Aluminum-Garnet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Proactive Cardiovascular Prevention Strategy in Subjects With High Genetic Risk
Status: UNKNOWN
Conditions: Cardiovascular Diseases|Primary Prevention
Interventions: OTHER: CVD risk estimation incorporating the PRS and guideline based preventive interventions.|OTHER: Standard GP care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Study of Apatinib Plus Radiotherapy vs. Apatinib in the Treatment of Hepatocellular Carcinoma With BCLC-C Stage I and Stage II Portal Vein Tumor Thrombus
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Apatinib|DEVICE: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Protective Effect for Liver Organ in Patients With Anti-TB Drugs Using of Acetylcysteine (NAC)
Status: UNKNOWN
Conditions: Protective Effect in TB-DIH|TB-DIH Means: Drug Induced Liver Function Abnormalities
Interventions: DRUG: Acteylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Therapeutic Efficacy of Tiludronic Acid on Inner Ear Involvement in Advanced Otosclerosis
Status: TERMINATED
Conditions: Otosclerosis
Interventions: DRUG: tiludronic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate The Relationship Between Plasma Drug Levels And Receptor Binding In Brain Using PET (Positron Emission Tomography) In Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-04995274
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Nimotuzumab and Irinotecan in Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: Nimotuzumab Humanized Monoclonal Antibody|DRUG: Nimotuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effects of Osmotic-Release Oral System (OROS) Methylphenidate (Concerta) on Attention and Memory
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Placebo|DRUG: OROS-methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Evaluation of the Bard® Luminexx™ Iliac Stent and Delivery System
Status: COMPLETED
Conditions: Iliac Artery Occlusive Disease
Interventions: DEVICE: Bard Luminexx Iliac Stent and Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of Cold Cap Therapy For Prevention of Hairloss in Pediatric Patients Receiving Chemotherapy For Non-Malignant Indications and Solid Tumors
Status: RECRUITING
Conditions: Alopecia
Interventions: DEVICE: Paxman Scalp Cooling System|OTHER: Alopecia Assessments|OTHER: Patient Reported Outcomes Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: The Relationship of Adiponectin in Adipose Tissue, Thy-1 in Plaques, and Inflammatory Mediators With Cardiac Diseases
Status: COMPLETED
Conditions: Heart Surgery
Interventions: PROCEDURE: CAD|PROCEDURE: VHD
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Randomised, Cross-Over, Nicotine Pharmacokinetic and Pharmacodynamic Study of Heated Tobacco Products Compared to Combustible Cigarettes
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: Heated tobacco device Intense (Product A)|OTHER: Heated tobacco device Regular (Product B)|OTHER: Heated tobacco device Menthol (Product C)|OTHER: Combustible cigarette (Product D)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of NIV-NAVA vs. N-CPAP After Extubation in Preterm Infants Study
Status: COMPLETED
Conditions: Endotracheal Extubation|Infant, Premature
Interventions: DEVICE: NIV-NAVA|DEVICE: N-CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel-trastuzumab in EGFR-mutated NSCLC Patients
Status: UNKNOWN
Conditions: NSCLC|HER2-expression|EGFR-mutation
Interventions: DRUG: Paclitaxel-trastzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnesium Sulfate Improves Postoperative Analgesia in Laparoscopic Gynecologic Surgeries
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Ketorolac|DRUG: Magnesium|DRUG: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: WE BEAT - HEART Club Fontan Wellness Project: A Virtual Resilience Promotion and Frailty Prevention Program
Status: RECRUITING
Conditions: Fontan Physiology|Frailty|Single Ventricle Heart Disease
Interventions: BEHAVIORAL: WE BEAT Group Wellness Education program - phase 1|BEHAVIORAL: HEART Club Home Exercise program - phase 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Empagliflozin on Left Atrial Function in Adults at Risk for Heart Failure
Status: NOT_YET_RECRUITING
Conditions: Hypertension|Cardiovascular Diseases
Interventions: DRUG: empagliflozin|DRUG: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single-dose, 2-way Crossover Open Study to Evaluate the Food Effect on the PK of HCP1201 in Healthy Volunteers
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: HCP1201, Fasted followed by fed|DRUG: HCP1201, Fed followed by fasted
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of Agents to Diminish the Risk of Hypoglycemia-induced Brain Injury in Type 1 Diabetes
Status: COMPLETED
Conditions: Hyperglycaemia (Diabetic)
Interventions: DRUG: Dichloroacetate|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Skin Irritation, Phototoxicity and Safety After Administration of LEO 90105 on Intact Skin of Healthy Japanese Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LEO 90105
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose:
Clinical trial: Comparison of Ketamine Plus Dexamethasone Versus Ketamine Alone for Prevention of Severe Shivering After Spinal Anesthesia in Cesarean Section
Status: RECRUITING
Conditions: Intraoperative Shivering|Ketamine With Shivering|Dexamethasone for Shivering|Severe Shivering
Interventions: DRUG: Ketamine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: 577nm Micropulse Laser Versus 532nm Subthreshold Laser Photocoagulation for Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DEVICE: 577-MPL|DEVICE: 532-SLP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Foods on Bile Acids, Metabolites, and Inflammation
Status: RECRUITING
Conditions: Inflammation|Hypertriglyceridemia|Metabolic Disease|Lipid Metabolism Disorder|Hyperlipidemias|Bile Acid Malabsorption
Interventions: BEHAVIORAL: Lentil|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: T-Lymphocyte Infusion or Standard Therapy in Treating Patients at Risk of Cytomegalovirus Infection After a Donor Stem Cell Transplant
Status: UNKNOWN
Conditions: Graft Versus Host Disease|Nonneoplastic Condition
Interventions: BIOLOGICAL: adoptive immunotherapy|BIOLOGICAL: alemtuzumab|BIOLOGICAL: in vitro-treated peripheral blood lymphocyte therapy|DRUG: foscarnet sodium|DRUG: ganciclovir|GENETIC: polymerase chain reaction|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: infection prophylaxis and management|PROCEDURE: peripheral blood stem cell transplantation|PROCEDURE: standard follow-up care|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intranasal Ketamine For Pain Control In Patients With Sickle Cell Disease And Vaso-occlusive Episode (VOE) In The PED
Status: UNKNOWN
Conditions: Sickle Cell Disease|Vaso-Occlusive Pain Episode in Sickle Cell Disease|Vaso-occlusive Crisis|Ketamine|Intranasal Ketamine|Analgesia
Interventions: DRUG: Intranasal ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Capnography During Percutaneous Transhepatic Cholangiodrainage (PTCD) (HepaBreath)
Status: COMPLETED
Conditions: Apnea|Hypoxemia|Complications
Interventions: PROCEDURE: capnography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: PREVENTION
Clinical trial: MB-CART19.1 in Refractory SLE
Status: NOT_YET_RECRUITING
Conditions: SLE - Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: MB-CART19.1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Controlled Trial to Determine the Effects of an Exercise Intervention on Physical Activity During Chemotherapy for Patients With Early Stage Breast Cancer
Status: COMPLETED
Conditions: Early Stage Breast Cancer
Interventions: BEHAVIORAL: Exercise prescription
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Continuous Infusion of Remidazolam for Colonoscopic Polypectomy in Elderly Patients
Status: COMPLETED
Conditions: Colon Disease
Interventions: DRUG: Remimazolam|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety, Pharmacodynamics and Pharmacokinetics of HSK3486 in Healthy Female Subjects.
Status: COMPLETED
Conditions: Anesthesia|Sedation
Interventions: DRUG: HSK3486|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nutritional Ketosis on Alcohol Metabolism
Status: RECRUITING
Conditions: Ketoses, Metabolic|Ketogenic Dieting|Alcohol Intoxication|Magnetic Resonance Imaging|Alcohol Drinking
Interventions: DIETARY_SUPPLEMENT: Ketone Supplement|OTHER: Control Diet|OTHER: Ketogenic diet|DRUG: Ethanol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Tumor Control Based on Serial Multiparametric MRI and Post-Treatment Biopsies For Patients Treated With Dose Intensification to the Dominant Intra-Prostatic Lesion (DIL) Using Ultra-Hypofractionated, MR-Guided Radiotherapy
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: 1.5 T Elekta Unity MR-Linac system|DEVICE: Hydrogel rectal spacer (SpaceOAR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Scaffold-guided Breast Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Implant Revision|Congenital Breast Defect Correction
Interventions: DEVICE: Surgical implantation of the PCL Breast scaffold with autologous fat grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Vienna Vascular Liver Disease Study
Status: RECRUITING
Conditions: Vascular Liver Disease|Portal Vein Thrombosis|Budd-Chiari Syndrome|Non-Cirrhotic Portal Hypertension|Rendu Osler Weber|Cardiac Cirrhosis|Porto-sinusoidal Vascular Disorder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Magnetic Resonance Spectroscopy Imaging in Predicting Response to Vorinostat and Temozolomide in Patients With Recurrent or Progressive Glioblastoma
Status: COMPLETED
Conditions: Adult Glioblastoma|Depression|Recurrent Adult Brain Tumor
Interventions: DRUG: vorinostat|DRUG: temozolomide|PROCEDURE: magnetic resonance spectroscopic imaging|OTHER: survey administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Iberdomide in People With Multiple Myeloma Who Have Had an Autologous Hematopoietic Stem Cell Transplant (AHCT)
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Iberdomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient Reported Outcomes, Smart Pill Bottle and Teleheath for Endocrine Therapy Adherence
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage 0 Breast Cancer AJCC v6 and v7|Stage I Breast Cancer AJCC v7|Stage IA Breast Cancer AJCC v7|Stage IB Breast Cancer AJCC v7|Stage II Breast Cancer AJCC v6 and v7|Stage IIA Breast Cancer AJCC v6 and v7|Stage IIB Breast Cancer AJCC v6 and v7|Stage IIIA Breast Cancer AJCC v7|Stage IIIB Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7|Stage III Breast Cancer AJCC v7
Interventions: OTHER: Telemedicine|OTHER: Best Practice|OTHER: Questionnaire Administration|OTHER: Quality-of-Life Assessment|OTHER: Survey Administration|BEHAVIORAL: Behavioral Intervention|OTHER: Educational Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Episodic Migraine in Adults
Status: RECRUITING
Conditions: Episodic Migraine
Interventions: BIOLOGICAL: Botulinum toxin type A|BIOLOGICAL: Botulinum toxin type A|OTHER: Placebo|BIOLOGICAL: Botulinum toxin type A|BIOLOGICAL: Botulinum toxin type A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Pilot Study of Plasma Renin Activity Guided vs Generic Combination Therapy for Hypertension
Status: COMPLETED
Conditions: Hypertension|Plasma Renin Activity
Interventions: DRUG: Hydrochlorothiazide|DRUG: Lisinopril|DRUG: Amlodipine|DRUG: metoprolol|DRUG: lisinopril/hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gaze and Postural Stability in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Vertigo|Dizziness|Falls Injury
Interventions: BEHAVIORAL: Gaze and Postural Stability|BEHAVIORAL: Standard Care Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT