pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Open Label Study of Sildenafil in Patients With Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: sildenafil citrate (UK-92,480)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Recombinant DNA and Adenovirus Expressing L523S Protein in Early Stage Non-Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-Small Cell Lung Cancer
Interventions: BIOLOGICAL: Recombinant DNA- pVAX/L523S|BIOLOGICAL: Recombinant adenovirus- Ad/L523S
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fasudil Trial for Treatment of Early Alzheimer's Disease (FEAD)
Status: NOT_YET_RECRUITING
Conditions: Cognitive Decline, Mild|Alzheimer Disease
Interventions: DRUG: Fasudil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU
Status: TERMINATED
Conditions: Deep Sedation|Ventilators, Mechanical|Critical Illness
Interventions: DRUG: Midazolam|DRUG: Propofol|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oronasopharyngeal Suction Versus Simple Nose and Mouth Wiping in Term Newborns
Status: COMPLETED
Conditions: Pregnancy, Childbirth and the Puerperium|Resuscitation
Interventions: PROCEDURE: Bulb Suctioning|PROCEDURE: Wiping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Chitosan and Carboxymethylcellulose Silver Dressings on Burn Wounds in Pediatric and Adult Subjects
Status: WITHDRAWN
Conditions: Bandages
Interventions: DEVICE: Opticell Ag+|DEVICE: Aquacel Ag+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Study of AXS-07 for the Acute Treatment of Migraine in Adults With a Prior Inadequate Response to an Oral CGRP Inhibitor (EMERGE)
Status: RECRUITING
Conditions: Migraine
Interventions: DRUG: AXS-07 (meloxicam-rizatriptan)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo and Adalimumab, in Subjects With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate But Have Active Disease
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Olokizumab 64mg q4w|DRUG: Olokizumab 64mg q2w|DRUG: Adalimumab 40mg q2w|DRUG: Placebo q2w
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Oxygenated Mouthwash and Mouth Foam
Status: ACTIVE_NOT_RECRUITING
Conditions: Gingival Diseases|Plaque, Dental|Quality of Life
Interventions: OTHER: Oxygenated Mouthwash|OTHER: Oxygenated mouth foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Cancer Chemoprevention by Metformin Hydrochloride Compared to Placebo in Oral Potentially Malignant Lesions
Status: UNKNOWN
Conditions: Oral Cancer
Interventions: DRUG: Metformin Hcl 500Mg 24Hr Sa Tab|OTHER: starch tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ketamine to Treat Patients With Post-comatose Disorders of Consciousness
Status: RECRUITING
Conditions: Disorder of Consciousness
Interventions: DRUG: Ketalar 50 MG/ML Injectable Solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lesion Network MApping Navigated Continuous Theta-burst STimulation for Motor REcovery in Acute Ischemic Stroke
Status: NOT_YET_RECRUITING
Conditions: Stroke, Acute Ischemic
Interventions: DEVICE: Continuous Theta-burst Stimulation|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of 'GLA5PR GLARS-NF1 Tab.' in Peripheral Neuropathic Pain
Status: COMPLETED
Conditions: Pain of Mononeuropathy
Interventions: DRUG: GLA5PR GLARS-NF1|DRUG: GLA5PR GLARS-NF1 placebo|DRUG: Pregabalin|DRUG: Pregabalin placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adenosine Dual Source Computed Tomography (CT) Versus Adenosine Single Photon Emission Computed Tomography (SPECT)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: RADIATION: Dual Source Multidetector CT (DSCT) w/ Adenosine enhancement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of RME on Engagement in Buprenorphine Treatment
Status: COMPLETED
Conditions: Opioid Use Disorder|Behavioral Symptoms|Psychiatric or Mood Diseases or Conditions
Interventions: BEHAVIORAL: Remote Motivational Enhancement (RME) Intervention Arm|OTHER: Information Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of 10-minute Chair Massage Versus 10-minute Break to Reduce Stress and Improve Well-being
Status: COMPLETED
Conditions: Stress, Psychological|Fatigue|Quality of Life
Interventions: DEVICE: Mechanical Chair Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pegylated Liposomal Doxorubicin Plus Albumin-Bound Paclitaxel and Trastuzumab in HER-2 Positive Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Pegylated Liposomal Doxorubicin|DRUG: Albumin-bound paclitaxel|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Aqueous Dexamethasone
Status: ACTIVE_NOT_RECRUITING
Conditions: Pharmacokinetics|Aqueous Dexamethasone|Inflammatory Cytokine Response
Interventions: DRUG: Dexamethasone Ophthalmic implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chloroquine/ Hydroxychloroquine Prevention of Coronavirus Disease (COVID-19) in the Healthcare Setting
Status: COMPLETED
Conditions: COVID19|Coronavirus|Acute Respiratory Illnesses
Interventions: DRUG: Chloroquine or Hydroxychloroquine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Fluoxetine and Bupropion to Treat Patients With Depression and Alcoholism
Status: TERMINATED
Conditions: Depression|Alcoholism|Suicidal Behavior
Interventions: DRUG: fluoxetine|DRUG: bupropion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Endogenous Inhibitory Modulation During Gastric and Somatic Stimulation
Status: COMPLETED
Conditions: Functional Dyspepsia
Interventions: PROCEDURE: gastric capsaicin with heterotopic stimulation/ distraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Complete Lymph Node Dissection vs Watchful Waiting in Patients With Malignant Melanoma (Thickness of 1,0mm+ and Evidence of Metastases in the Sentinel Node)
Status: COMPLETED
Conditions: Melanoma
Interventions: PROCEDURE: Completion Lymphadenectomy|PROCEDURE: Clinical Monitoring (Palpation and node ultrasound)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TRabecular Metal Economic and Clinical Knee Trial
Status: RECRUITING
Conditions: Total Knee Replacement|Orthopedics
Interventions: DEVICE: Persona (Zimmer) posterior stabilised uncemented Trabecular Metal™ (Tibia and Femur) prosthesis|DEVICE: Persona (Zimmer) posterior stabilised cemented Trabecular Metal™ (Tibia and Femur) prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Iron-fortified Flavoured Skimmed Milk With or Without Vitamin D in Iron Deficient Women
Status: COMPLETED
Conditions: Iron Deficiency
Interventions: OTHER: Iron fortified flavoured skimmed milk with or without vitamin D in iron deficient women
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Evaluating the Efficacy and Safety on Moderate to Severe Dry Eye
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: HBM9036 0.25% Ophthalmic Solution|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characterization of Retinal Disease Progression in Eyes With Non Proliferative Diabetic Retinopathy in Diabetes Type 2 Using Non-invasive Procedures (CHART)
Status: ACTIVE_NOT_RECRUITING
Conditions: NPDR - Non Proliferative Diabetic Retinopathy|Diabetes Mellitus, Type 2|Retinal Disease
Interventions: OTHER: Biomarkers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ropivacaine Block Alone or With Perineural or Systemic Dexamethasone for Pain in Shoulder Surgery
Status: COMPLETED
Conditions: Shoulder Injury
Interventions: DRUG: Ropivacaine|DRUG: Dexamethasone|DRUG: Dexamethasone|DRUG: Normal saline|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: MR Lymphography and Magnetic Sentinel Lymph Node Biopsy in Melanoma Patients
Status: NOT_YET_RECRUITING
Conditions: Melanoma (Skin)
Interventions: DEVICE: Magnetic sentinel lymph node biopsy by use of Magtrace®, in combination with SentiMag® and DiffMag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study Evaluating Impact of IL-7 on CD4 Lymphopenia, Risks of Severe Haematological Toxicity and Tumor Progression in Metastatic Breast Cancer Patients
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: placebo|DRUG: interleukin 7|DRUG: interleukin 7|DRUG: interleukin 7
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Ageing During Therapy in AYA Cancer Patients
Status: RECRUITING
Conditions: Cancer|Leukemia|Hodgkin Lymphoma|Testicular Cancer|Osteosarcoma|Ewing Sarcoma|Breast Cancer|Cervical Cancer
Interventions: PROCEDURE: Blood sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ALLOGRAFT, A Study to Evaluate the Renal Protective Effects of Losartan (0954-222)(COMPLETED)
Status: COMPLETED
Conditions: High Blood Pressure
Interventions: DRUG: losartan potassium|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1-2 MAHCT w/ TCell Depleted Graft w/ Simultaneous Infusion Conventional and Regulatory T Cell
Status: COMPLETED
Conditions: Myeloid Leukemia, Chronic|Acute Myelogenous Leukemia|Myelodysplastic Syndromes (MDS)|Lymphoma, Non-Hodgkin|Acute Lymphoblastic Leukemia (ALL)|Myeloproliferative Syndrome|Acute Myeloid Leukemia|Acute Leukemia|Chronic Myelogenous Leukemia
Interventions: BIOLOGICAL: Conventional T cells (Tcon) and Regulatory T cells (Treg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Tolerance of Regadenoson in Subjects With Renal Impairment
Status: COMPLETED
Conditions: Kidney Diseases|Coronary Artery Disease
Interventions: DRUG: Regadenoson|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase II Trial of VDJ001 in Patients With Moderate-to-severe Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Recombinant Humanized Anti-interleukin-6 Receptor Monoclonal Antibody Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Efficacy of the Dexmedetomidine Transdermal System for Postoperative Analgesia Following Abdominoplasty
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: DMTS|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of HY004 Treatment in Adult Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (r/r B-ALL)
Status: NOT_YET_RECRUITING
Conditions: B-cell Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: HY004|DRUG: Cyclophosphamide|DRUG: Fludarabine Phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Tolerance, Efficacy and Pharmacokinetics of TQB3454 Tablets
Status: UNKNOWN
Conditions: Advanced Solid Tumor or Hematologic Tumor
Interventions: DRUG: TQB3454
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endostar Durative Transfusion Combining With Gemcitabine-Cisplatin to Treat Non-Small Cell Lung Cancer (NSCLC)
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Endostar -Continued Pumping into+GP|DRUG: Endostar -injecting into +GP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pediatric Dysphagia Outcomes After Injection Laryngoplasty for Type I Laryngeal Cleft
Status: COMPLETED
Conditions: Dysphagia|Aspiration|Quality of Life
Interventions: PROCEDURE: Injection laryngoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Remimazolam and Dexmedetomidine for Intraoperative Sedation
Status: COMPLETED
Conditions: Orthopedic Disorder
Interventions: DRUG: Remimazolam|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Acetaminophen Versus Ibuprofen in Treating Recurrent Apthous Ulcers in Pediatric Celiac Disease
Status: NOT_YET_RECRUITING
Conditions: Celiac Disease in Children
Interventions: DRUG: Acetaminophen|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Prior Chemotherapy on Clinical Benefit With Erlotinib in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer With or Without EGFR Gene Mutation
Status: COMPLETED
Conditions: Advanced Non-Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: Docetaxel/cisplatin|DRUG: Pemetrexed/cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cromolyn Detection of Silent Aspiration
Status: TERMINATED
Conditions: Gastroesophageal Reflux|Respiratory Aspiration|Idiopathic Pulmonary Fibrosis|Lung Transplantation
Interventions: DRUG: Cromolyn Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Trial to Assess the Pharmacokinetic Profile (e.g., Uptake, Distribution and Excretion of a Substance in the Body) of Nomegestrol Acetate (NOMAC), Estradiol (E2) and Estrone (E1) After Multiple and Single Dose Administration of the Combined Oral Contraception NOMAC-E2 (COMPLETED)(P05822)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: nomegestrol acetate and estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A run-in Study on the Safety and Tolerability of a Fasting Mimicking Diet in Relapsing Remitting Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis
Interventions: DIETARY_SUPPLEMENT: 7-day Fasting-Mimicking Diet (7-DAY FMD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing PLA to HIGRT (PROVE-HCC)
Status: TERMINATED
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: Percutaneous Local Ablation|RADIATION: Hypofractionated Image Guided Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Optimizing Stroke Family Caregiver Support Across the Care Continuum by Improving the Timing of Intervention Delivery
Status: COMPLETED
Conditions: Stroke|Caregiver Social Support|Caregiver Mental Health|Caregiver Sense of Control Over Life|Caregiver Participation
Interventions: BEHAVIORAL: Timing it Right Stroke Family Support Person Intervention|BEHAVIORAL: Self-directed program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Ketamine and Propofol vs Propofol for Emergency Department Sedation: A Prospective Randomized Trial
Status: COMPLETED
Conditions: Sedation
Interventions: PROCEDURE: 1:1 ketamine-propofol mixture sedation|PROCEDURE: Propofol Sedation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of MIM-D3 Ophthalmic Solution for the Treatment of Dry Eye
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: MIM-D3 Ophthalmic Solution|DRUG: Placebo Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy-related Toxicity, Nutritional Status and Quality of Life
Status: UNKNOWN
Conditions: Toxicity Due to Chemotherapy|Cancer Cachexia|Metastatic Colorectal Cancer|Quality of Life|Dietary Modification
Interventions: DIETARY_SUPPLEMENT: NUTRIDRINK Compact Protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy Study to Compare Vildagliptin to Pioglitazone as Adding on Metformin in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: vildagliptin|DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minocycline and/or Omega-3 Fatty Acids Added to Treatment as Usual for At Risk Mental States
Status: COMPLETED
Conditions: At Risk Mental State (ARMS)|Psychosis
Interventions: DRUG: Minocycline|DRUG: Omega-3 fatty acids|DRUG: Placebo|DRUG: Minocycline Plus Omega-3 fatty acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Radiotherapy for Spine Tumors
Status: COMPLETED
Conditions: Spinal Metastases|Vertebral Metastases|Benign Spinal Tumors|Chordoma|Meningioma|Schwannoma|Neurofibroma|Paragangliomas|Arteriovenous Malformations
Interventions: RADIATION: SBRT for Benign Extradural Spine Tumors|RADIATION: SBRT for Vertebral/Paraspinal Metastases
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia
Status: COMPLETED
Conditions: Trigeminal Neuralgia
Interventions: DRUG: Lamictal®|DRUG: Tegretol®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A2 AR as a Novel Biomarkers for Physician Decision-making Improvement Evaluation's Patients With Suspected Acute Coronary Syndrome But Negative Troponin.
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: BIOLOGICAL: blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Integrating Family Planning Services Into HIV Care and Treatment in Nyanza Province, Kenya
Status: COMPLETED
Conditions: Unintended Pregnancy|HIV Infections
Interventions: PROCEDURE: Integrated family planning/HIV care and treatment services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the H1-Coil TMS- Double Blind Placebo Controlled Study in Adolescent Patients Suffering From Major Depression
Status: UNKNOWN
Conditions: Depression
Interventions: DEVICE: Deep TMS Brainsway's H coil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of 5 and 10 Days Treatment With Penicillin Against Sore Throat Caused by Streptococci
Status: COMPLETED
Conditions: Tonsillitis
Interventions: DRUG: Phenoxymethylpenicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Protein on Muscle, Gut Microbiota and Clinical Outcome in Patients With Lung Cancer-related Sarcopenia
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer|Sarcopenia
Interventions: DIETARY_SUPPLEMENT: soy protein|DIETARY_SUPPLEMENT: whey protein|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Benapenem in Subjects With Renal Impairment
Status: COMPLETED
Conditions: Complicated Urinary Tract Infection; Cuti
Interventions: DRUG: benapenem|DRUG: benapenem|DRUG: benapenem
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Population Pharmacokinetic-pharmacodynamic (PK-PD) Modeling of Co-administered Gabapentin in Neuropathic Pain
Status: COMPLETED
Conditions: Post-traumatic Neuropathic Pain
Interventions: DRUG: gabapentin and venlafaxine|DRUG: gabapentin and donepezil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Minimum Number of Needling Required to Optimize Trigger Point Injections Outcome
Status: ENROLLING_BY_INVITATION
Conditions: Myofascial Pain|Myofascial Trigger Point Pain
Interventions: COMBINATION_PRODUCT: 1% plain lidocaine and 0.25% plain bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of DFD-06 Cream in the Treatment of Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Chronic Stable Plaque Psoriasis
Interventions: DRUG: DFD06-Cream|DRUG: Vehicle Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Oral Melatonin in Preventing Postoperative Delirium for Patients Undergoing Orthopedic Surgery Under General Anesthesia
Status: COMPLETED
Conditions: Delirium, Anesthesia Emergence|Delirium
Interventions: DRUG: Melatonin|OTHER: No intervention|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Family Connections for Caregivers of People With Suicidal Behavior
Status: ACTIVE_NOT_RECRUITING
Conditions: Relatives
Interventions: BEHAVIORAL: Family Connections Protocol for Relatives of Patients with SBD.|BEHAVIORAL: Treatment as Usual Optimized Protocol (TAU-O)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotic on Rhinovirus Induced Colds
Status: COMPLETED
Conditions: Common Cold
Interventions: BIOLOGICAL: Bifidobacterium animalis subsp. lactis Bl-04|OTHER: sucrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Multi-center RCT to Evaluate Subsegmental BTVA Treatment for Severe Emphysema
Status: NOT_YET_RECRUITING
Conditions: Severe Emphysema
Interventions: PROCEDURE: BTVA treatment plus optimal medical therapy (GOLD guidelines)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monoclonal Antibodies in Recurrent or Refractory B Cell Acute Lymphoblastic Leukaemia (ALL) (MARALL)
Status: UNKNOWN
Conditions: Recurrent or Refractory B Cell Acute Lymphoblastic Leukaemia
Interventions: BIOLOGICAL: humanised monoclonal antibody, veltuzumab|BIOLOGICAL: humanised monoclonal antibody epratuzumab|BIOLOGICAL: humanised monoclonal antibodies veltuzumab and epratuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the 755nm Alexandrite Laser for the Treatment of Tattoos
Status: COMPLETED
Conditions: Tattoos
Interventions: DEVICE: 755nm Alexandrite Laser|DEVICE: 755nm Alexandrite Laser with CAP Array
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Safety, Tolerability and Pharmacokinetics of Ceftaroline in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: 600 mg Ceftaroline fosamil|DRUG: Placebo|DRUG: 600 mg Ceftaroline fosamil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Early Feasibility Study of the Edwards FORMA Tricuspid Transcatheter Repair System
Status: COMPLETED
Conditions: Tricuspid Valve Regurgitation
Interventions: DEVICE: Edwards FORMA Tricuspid Transcatheter Repair System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cross-vaccination Study of GSK Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine (GSK 1437173A) in Subjects Who Previously Received Placebo in ZOSTER-006 (NCT01165177) and ZOSTER-022 (NCT01165229) Studies.
Status: COMPLETED
Conditions: Herpes Zoster
Interventions: BIOLOGICAL: Herpes Zoster Vaccine GSK1437173A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Double-blind Comparative Study of the Efficacy and Safety of E3810 10mg Once and Twice Daily in Maintenance Therapy for PPI Resistant Gastroesophageal Reflux Disease Patients
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: Rabeprazole|DRUG: Rabeprazole|DRUG: Rabeprazole|DRUG: Rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of Low Dose Ozone on Airway Inflammatory Responses in Adults With Asthma - Sedentary Nasal Ozone (Asthma SNOZ)
Status: SUSPENDED
Conditions: Asthma, Allergic
Interventions: OTHER: Ozone|OTHER: FA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Repetitive Nerve Stimulation to Improve Recovery After Stroke
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: Repetitive peripheral nerve stimulation|DEVICE: Sham Repetitive peripheral nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Conception of a Diagnosis, Prognosis and Therapeutic Decision Tool for Patients With Autoimmunity and Inflammation
Status: NOT_YET_RECRUITING
Conditions: Autoimmune Lymphoproliferative Syndrome|Autoimmune Cytopenia|Autoimmune Diseases|Autoimmune Anemia|Autoimmune Thrombocytopenia|Autoimmune Hepatitis|Autoimmune Diabetes|Autoimmune Rheumatologic Disease|Systemic Lupus Erythematosus|Juvenile Idiopathic Arthritis|Hemophagocytic Lymphohistiocytoses|EBV Lymphoproliferation|RAS-Associated Autoimmune Leucoproliferative Disease|Primary Immunodeficiency|APECED|IPEX|BENTA|Enteropathy, Autoimmune|Combined Immunodeficiency|IBD
Interventions: BIOLOGICAL: Collection of samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Investigate the Safety and Effect of the Study Drug (FE 204205) in Patients With Cirrhotic Portal Hypertension
Status: TERMINATED
Conditions: Portal Hypertension
Interventions: DRUG: FE 204205|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Investigation of the Sleep Architecture and Consequent Cognitive Changes in Olanzapine-Treated Depressed Patients
Status: COMPLETED
Conditions: Bipolar Disorder|Depression|Depressive Disorder
Interventions: DRUG: Olanzapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis
Status: COMPLETED
Conditions: Residual Disease|Aggressive Periodontitis
Interventions: PROCEDURE: Open flap debridement|OTHER: Placebo|DIETARY_SUPPLEMENT: Omega-3 polyunsaturated fatty acids|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Transcranial Magnetic Stimulation Associated to Sensory Therapy for Treatment of Motor Function of Upper Limb of Stroke Patients
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: Transcranial Magnetic Stimulation|BEHAVIORAL: conventional sensory therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SINGULAIR (R) as Complementary Therapy to Fixed Association Regimen (0476-363)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: MK0476, montelukast sodium / Duration of Treatment: 8 Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thiamine Supplementation to Improve Cardiac Function in Patients With Congestive Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Thiamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Nitazoxanide for Post Exposure Prophylaxis of COVID-19 in Household Contacts
Status: UNKNOWN
Conditions: Covid19|SARS-CoV-2 Infection|Households Contacts
Interventions: DRUG: Nitazoxanide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of E2020 in Patients With Dementia With Lewy Bodies (DLB), Followed by a Long-term Extension Phase
Status: COMPLETED
Conditions: Dementia With Lewy Bodies (DLB)
Interventions: DRUG: Donepezil 5 mg|DRUG: Donepezil 10 mg|DRUG: Donepezil matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Canakinumab in Patients Aged 4 Years or Older Diagnosed With Cryopyrin-associated Periodic Syndromes (CAPS) in Canada
Status: COMPLETED
Conditions: Cryopyrin Associated Periodic Syndrome
Interventions: DRUG: canakinumab (company code: ACZ885D)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Laparoscopic Inguinal Hernia Repair
Status: COMPLETED
Conditions: Hernia, Inguinal|Inguinal Hernia, Direct|Inguinal Hernia, Indirect|Hernia, Femoral|Recurrence|Neuralgia, Atypical|Neuralgia, Ilioinguinal|Neuralgia, Iliohypogastric Nerve
Interventions: PROCEDURE: TEP without fixation|PROCEDURE: TEP with fixation|PROCEDURE: TAPP without fixation|PROCEDURE: TAPP with fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Isoflavones for Promoting Calcium Absorption and Preventing Bone Loss in Post Menopausal Women
Status: COMPLETED
Conditions: Osteoporosis|Osteopenia
Interventions: DIETARY_SUPPLEMENT: Genistein vs Risedronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Interrupting Prolonged Sitting With Bouts of Physical Activity on Neurocognitive Function in Obesity
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: BEHAVIORAL: Physical Activity Breaks Intervention|BEHAVIORAL: Talking Breaks Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dietary Fiber for Fecal Incontinence
Status: COMPLETED
Conditions: Fecal Incontinence
Interventions: DIETARY_SUPPLEMENT: Psyllium|DIETARY_SUPPLEMENT: Gum Arabic|DIETARY_SUPPLEMENT: carboxymethylcellulose|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Quality of Life in Patients With Asymptomatic Monoclonal Gammopathies
Status: RECRUITING
Conditions: Monoclonal Gammopathy of Undetermined Significance|Smoldering Plasma Cell Myeloma
Interventions: OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Educational Program on Dietary Adherence and Nutritional Knowledge in Chronic Kidney Disease Patients (EPAK)
Status: RECRUITING
Conditions: Chronic Kidney Disease|Predialysis|Peritoneal Dialysis|Hemodialysis|Educational Activities|Adherence|Nutritional Status
Interventions: OTHER: Nutritional education and psychological intervention|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study of Carfilzomib Taken With Thalidomide and Dexamethasone in Relapsed AL Amyloidosis
Status: COMPLETED
Conditions: Amyloidosis
Interventions: DRUG: Carfilzomib|DRUG: Thalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetic Apnea Prevention(MAGNAP) Device to Treat Obstructive Sleep Apnea:First-In-Human Study of Feasibility and Safety
Status: RECRUITING
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Magnap
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Finding the Optimum Regimen for Duchenne Muscular Dystrophy
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: Prednisone|DRUG: Prednisone|DRUG: Deflazacort
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-blind, Safety and Efficacy of Recombinant Human Erythropoietin in Amyotrophic Lateral Sclerosis
Status: RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: recombinant human erythropoietin(rhEPO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Comparison of a Prophylactic Intraligamentary Injection of Piroxicam Versus Mepecaine of Post-endodontic Pain
Status: UNKNOWN
Conditions: Pulpitis - Irreversible
Interventions: PROCEDURE: intraligamentary injection piroxicam|PROCEDURE: Intraligamentary mepevacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treximet for Prevention of Post Traumatic Headache Associated With Cognitive Dysfunction
Status: TERMINATED
Conditions: Post-Traumatic Headache
Interventions: DRUG: sumatriptan/naproxen sodium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Benefits and Affordability of a Program to Improve the Care of Common Mental Disorders in Primary Care
Status: COMPLETED
Conditions: Depressive Disorders|Anxiety Disorders|Depression
Interventions: OTHER: Collaborative Stepped Care Intervention|OTHER: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ONC201 and Atezolizumab in Obesity-Driven Endometrial Cancer
Status: RECRUITING
Conditions: Endometrial Cancer|Metastasis
Interventions: DRUG: Atezolizumab|DRUG: ONC201
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycemic Index Variation During Low-carbohydrate Enteral Formula With and Without Fructose in Critically Ill Patients
Status: COMPLETED
Conditions: Critical Illness
Interventions: DIETARY_SUPPLEMENT: Enteral Formula With Fructose|DIETARY_SUPPLEMENT: Enteral Formula Without Fructose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cerclage for Prevention on Preterm Birth in Women With Placenta Previa
Status: WITHDRAWN
Conditions: Premature Birth|Placenta Previa
Interventions: PROCEDURE: Placement of a Cervical Cerclage|PROCEDURE: Standard Expectant Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Implementation, Efficacy and Costs of Inpatient Equivalent Home-Treatment in German Mental Health Care
Status: UNKNOWN
Conditions: Mental Disorder|Personality Disorders|Schizo Affective Disorder|Anxiety Disorders|Eating Disorders|Addiction
Interventions: OTHER: Inpatient Equivalent Home Treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Monoclonal Antibody 3F8 and GM-CSF in Treating Young Patients With High-Risk, Refractory or Relapsed Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: BIOLOGICAL: monoclonal antibody 3F8|BIOLOGICAL: sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia (Closed to Accrual 4-22-2011)
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Adult B Acute Lymphoblastic Leukemia|Childhood B Acute Lymphoblastic Leukemia
Interventions: DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Daunorubicin Hydrochloride|DRUG: Dexamethasone|DRUG: Doxorubicin Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Mercaptopurine|DRUG: Methotrexate|DRUG: Pegaspargase|DRUG: Prednisone|RADIATION: Prophylactic Cranial Irradiation|DRUG: Thioguanine|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Goals for Adherence With Low-cost Incentives
Status: RECRUITING
Conditions: ART|HIV
Interventions: BEHAVIORAL: Incentivization based on gradually increasing, externally chosen adherence goals|BEHAVIORAL: End of year 1 adherence prize drawing|BEHAVIORAL: SMS motivational messages + reminder of prize drawing|BEHAVIORAL: Year 2 re-allocation based on year 1 performance|BEHAVIORAL: End of Year 2 viral suppression prize drawing|BEHAVIORAL: Incentivization based on gradually increasing self-chosen adherence goals|BEHAVIORAL: Incentivization based on a fixed adherence goal|BEHAVIORAL: SMS motivational messages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy Trial of Iron, Zinc and Vitamin A Fortified Rice in Children in Satun, Thailand
Status: COMPLETED
Conditions: Vitamin A Deficiency|Iron Deficiency|Zinc Deficiency
Interventions: DIETARY_SUPPLEMENT: fortified extruded rice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Platelet Aggregation After tiCagrelor Inhibition and FentanYl Trial (PACIFY)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: OTHER: Removal of Fentanyl from peri-procedural analgesia|DRUG: Fentanyl|DRUG: Lidocaine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Melatonin on Feeding Intolerance and Incidence of Necrotizing Enterocolitis in Preterm Infants
Status: COMPLETED
Conditions: Preterm Infant|Feeding Intolerance|Necrotizing Enterocolitis
Interventions: DRUG: Melatonin 20 mg|DRUG: Traditional antibiotic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chidamide/Everolimus for PIK3CA Wild-type/Mutant HR+/HER2- Advanced Breast Cancer
Status: RECRUITING
Conditions: HR+/HER2- Advanced Breast Cancer|Targeted Therapy
Interventions: DRUG: Everolimus|DRUG: Chidamide|DRUG: Endocrine therapy|DRUG: Ovarian function suppression(OFS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3D Lung Reconstructions Using Open-source Software for Lung Cancer Surgery
Status: COMPLETED
Conditions: Lung Cancer|Thoracic Surgery, Video-Assisted|Lobectomy|Segmentectomy|Humans|Surgery
Interventions: DEVICE: Preoperative 3D lung reconstruction created with open-source software
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Trial of Active Immunotherapy With Globo H-KLH (OPT-822) in Metastatic Breast Cancer Subjects
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: BIOLOGICAL: OPT-822/OPT-821(30 μg/100 μg)|BIOLOGICAL: Phosphate Buffer Saline (PBS)|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-center Trial of ESK981 in Combination With Nivolumab in Patients With Metastatic Renal Cell Carcinoma
Status: TERMINATED
Conditions: Renal Cell Carcinoma, Metastatic
Interventions: DRUG: ESK981|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Derived Neurotrophic Factor as a Predictor of Response to Treatment in Bipolar Depression and Mania: 16-weeks Follow-up With Quetiapine XR
Status: UNKNOWN
Conditions: BIPOLAR DISORDER
Interventions: DRUG: quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Portal Flow Pulsatility as a Risk Factor for Acute Kidney Injury After Cardiac Surgery
Status: COMPLETED
Conditions: C.Surgical Procedure; Cardiac|Acute Kidney Injury|Postoperative Complications|Right-Sided Heart Failure|Cardio-Renal Syndrome
Interventions: PROCEDURE: Cardiac surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p