pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of Endurance Training on Patients With Reduced Left Ventricular Ejection Fraction (LVEF) and Cardiac Resynchronisation Therapy Especially for Cardiac Arrhythmias
Status: UNKNOWN
Conditions: Heart Failure|Cardiac Resynchronisation Therapy|Sudden Cardiac Death
Interventions: BEHAVIORAL: endurance training|BEHAVIORAL: exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemo-Immunotherapy Followed by Durvalumab and Ceralasertib in Treatment Naïve Patients With Extensive Stage Small Cell Lung Cancer
Status: RECRUITING
Conditions: Extensive Stage Small Cell Lung Cancer
Interventions: DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Etoposide|DRUG: Durvalumab|DRUG: Ceralasertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of SHR-A1921 or SHR-A2009 in Previously Treated Advanced NSCLC
Status: NOT_YET_RECRUITING
Conditions: NSCLC
Interventions: DRUG: SHR-A2009|DRUG: SHR-A1921
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Feasibility of Magnetic Navigated Capsule Endoscope in the Upper Gastrointestinal Tract Examination
Status: COMPLETED
Conditions: Healthy Patient on Good Condition
Interventions: DEVICE: capsule endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: B Cell and Antibody Response to Seasonal Influenza Vaccines in Younger and Older Adults
Status: RECRUITING
Conditions: Influenza
Interventions: DRUG: Fluzone|DRUG: Flucelvax|DRUG: Fluzone High-Dose|DRUG: Fluad
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Whole-body Vibration Training on Body Composition in Adolescents With and Without Down Syndrome
Status: COMPLETED
Conditions: Down Syndrome
Interventions: DEVICE: Whole-body vibration training (Power Plate®) on bone mass and bone metabolism in adolescents with and without Down syndrome.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Pilot RCT: the Impact of a Virtual MBSR Course on Women With Primary Infertility
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Infertility|Mental Health Issue|Quality of Life
Interventions: BEHAVIORAL: Mindfulness-Based Stress Reduction course
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Helping Ease Anxiety and Depression Following Stroke Stage 3
Status: COMPLETED
Conditions: Stroke|Cerebrovascular Accident Due to Cerebral Artery Occlusion|Anxiety|Depression
Interventions: BEHAVIORAL: HEADS: UP (Helping Ease Anxiety and Depression)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-Active PD: Looking at Physical Activity Behavior Change in Parkinson's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: Occupational therapy intervention group|BEHAVIORAL: Disease management education group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Melperone (an Anti-Psychotic) in Patients With Psychosis Associated With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease|Psychotic Disorders
Interventions: DRUG: Melperone HCl|DRUG: Melperone HCl|DRUG: Melperone HCl|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ranibizumab for Treatment of Persistent Diabetic Neovascularization Assessed by Wide-Field Imaging
Status: COMPLETED
Conditions: Proliferative Diabetic Retinopathy
Interventions: DRUG: ranibizumab|PROCEDURE: Laser photocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PSLT Compared to Prostaglandin Analogue Eye Drops
Status: UNKNOWN
Conditions: Open Angle Glaucoma|Ocular Hypertension
Interventions: PROCEDURE: PSLT|DRUG: Prostaglandin analogue eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bladder Directed vs. Pelvic Floor Therapy in IC/BPS
Status: RECRUITING
Conditions: Cystitis, Interstitial|Painful Bladder Syndrome
Interventions: PROCEDURE: Pelvic Floor Physical Therapy|DRUG: Bladder Instillations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Pharmacokinetics (PK) of DFN-15 vs Comparator and Food-effect on DFN-15 PK in Healthy Adult Subjects
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: DFN-15 (fasted)|DRUG: DFN-15 (fed)|DRUG: Comparator Celebrex® (fed)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics Of Umeclidinium and Vilanterol in Healthy Chinese, a Randomized, Open Label, 3 Crossover Study.
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: UMEC/VI 125/25 mcg|DRUG: UMEC/VI 62.5/25 mcg|DRUG: UMEC 125 mcg|DRUG: UMEC 62.5 mcg|DRUG: VI 25 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Resiniferatoxin for Knee Pain in Moderate to Severe Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Pain, Knee
Interventions: DRUG: Resiniferatoxin|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SUPPORT Online Training Platform for Type 1 Diabetes Self-management Education and Support (SUPPORT)
Status: UNKNOWN
Conditions: Type 1 Diabetes Mellitus With Hypoglycemia
Interventions: OTHER: SUPPORT online platform for people with type 1 diabetes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Immune Response of Breast Cancer Patients Treated With Levobupivacaine Using Paravertebral or Superficial Chest Blocks
Status: NOT_YET_RECRUITING
Conditions: Paravertebral Block|Pectoralis and Serratus Plane Nerve Blocks|Breast Cancer|Immunologic Suppression|Levobupivacaine
Interventions: PROCEDURE: Paravertebral nerve block (PVB)|PROCEDURE: Pectoralis and Serratus Plane Nerve Blocks (PECS 2)|DEVICE: Regional anesthetic technique with ultrasound guidance|DEVICE: Regional anesthetic technique with peripheral nerve stimulation.|DRUG: Levobupivacaine 0.5%|PROCEDURE: General anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cognitive Behavioral Therapy for Insomnia for the Dementia Caregiving Dyad
Status: COMPLETED
Conditions: Cognitive Impairment|Dementia
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia (CBTi) via Videoconference
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation
Status: COMPLETED
Conditions: Hyperpigmentation
Interventions: DRUG: Desonide|DRUG: Niacinamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of Nivolumab to Chemotherapy in Treatment of Soft Tissue Sarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Skin Angiosarcoma|Skin Radiation-Related Angiosarcoma|Visceral Angiosarcoma
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Cabozantinib S-malate|PROCEDURE: Computed Tomography|PROCEDURE: FDG-Positron Emission Tomography|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Nivolumab|DRUG: Paclitaxel|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Formulation of Insulin for Preterm Infants
Status: TERMINATED
Conditions: Premature Birth of Newborn
Interventions: BIOLOGICAL: Oral Formulation of Insulin|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Continuation Clinical Trial of Oral Vorinostat (MK-0683) in Advanced Cancers (MK-0683-007)
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: DRUG: vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mulligan Mobilizations and McKenzie Exercises Along With Neural Mobilizations in Cervical Spondylosis
Status: RECRUITING
Conditions: Spondylosis
Interventions: OTHER: Mulligan with upper limb movement|OTHER: McKenzie exercises with neural mobilizations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cetuximab, Gemcitabine, and Oxaliplatin in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: Cetuximab|DRUG: Gemcitabine Hydrochloride|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter "Ablate and Resect" Study of Novilase® Interstitial Laser Therapy for the Ablation of Small Breast Cancers
Status: UNKNOWN
Conditions: Malignant Tumor
Interventions: DEVICE: Novilase Interstitial Laser Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melancholic Depression and Insomnia as Predictors of Response to Quetiapine in Patients With Major Depression
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Quetiapine 50 MG Extended Release Oral Tablet|DRUG: Quetiapine Fumarate XR 150-300 mg|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of Laying Early a Gastric Band on the Prevention of Morbid Obesity Randomized Checked Against Standard Management of Obesity in This Population.
Status: UNKNOWN
Conditions: Obesity
Interventions: PROCEDURE: gastric ring surgery|OTHER: nutritional help
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Citalopram Hydrobromide Tablets 40 mg (Torrent Pharmaceuticals Ltd) and RLD Tablets 40 mg (Manufactured By Forest Pharmaceuticals Inc, Missouri) in 24+2 Normal Healthy Male Subjects Under Fasting Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Citalopram Hydrobromide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Study of Anlotinib Combined With Pemetrexed in Patients With Advanced Nonsquamous NSCLC
Status: UNKNOWN
Conditions: Non-squamous Cell Non-Small Cell Lung Cancer
Interventions: DRUG: Anlotinib plus Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Treatment of Vulnerable Individuals With Non-Severe SARS-CoV-2 Infection
Status: UNKNOWN
Conditions: Covid19|Covid19 Drug Treatment|Severe Acute Respiratory Syndrome Coronavirus 2|SARS-CoV2 Infection
Interventions: DRUG: Nitazoxanide and Ciclésonide|DRUG: Telmisartan 20Mg Oral Tablet|DRUG: Paracetamol|DRUG: Fluoxétine and Budésonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fatigability Compared Men and Women Induced According to the Distance Traveled on an Ultra-marathon in the Mountains
Status: COMPLETED
Conditions: Ultra-marathon Runners
Interventions: OTHER: Neuromuscular tests in isometric mode|DEVICE: Transcranial Magnetic Stimulation (TMS)|OTHER: Neuromuscular fatigue assessment test|OTHER: treadmill|BIOLOGICAL: Blood sample|BIOLOGICAL: Urinary sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Identification of Factors Associated With Treatment Response in Patients With Polycythemia Vera, Essential Thrombocythemia, and Pre-myelofibrosis.
Status: NOT_YET_RECRUITING
Conditions: Myeloproliferative Neoplasm
Interventions: DIAGNOSTIC_TEST: Next-generation sequencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intratumoral/Intralesional Administration of MK-4621/JetPEI™ With or Without Pembrolizumab in Participants With Advanced/Metastatic or Recurrent Solid Tumors (MK-4621-002)
Status: TERMINATED
Conditions: Advanced Solid Tumors
Interventions: BIOLOGICAL: MK-4621|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home Telemedicine to Optimize Health Outcomes in High-Risk Youth With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: BEHAVIORAL: Home Telehealth T1D C2oYoT1-HR|BEHAVIORAL: Personalized Behavioral Health|BEHAVIORAL: Personalized Adherence Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Hou Gu Mi Xi in Patients With Peptic Ulcer Diseases
Status: COMPLETED
Conditions: Peptic Ulcer Disease
Interventions: OTHER: Hou Gu Mi Xi|OTHER: Placebo|DRUG: Rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TJ202 Combined With Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma in Relapse|Refractory Multiple Myeloma
Interventions: DRUG: TJ202 and Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined TACE, TKI/Anti-VEGF and ICIs as Conversion Therapy for Advanced Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma Non-resectable
Interventions: PROCEDURE: TACE|DRUG: Lenvatinib|DRUG: Anti-PD-1 monoclonal antibody|DRUG: Bevacizumab Biosimilar IBI305 plus sintilimab|DRUG: Bevacizumab plus Atezolizumab|DRUG: apatinib plus camrelizumab|DRUG: Sorafenib|DRUG: Donafenib|DRUG: Regorafenib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Effect of Food on the Bioavailability of Mebendazole From a Fast-Disintegrating Chewable Formulation of Mebendazole in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Mebendazole - fasted state (Treatment A)|DRUG: Mebendazole - fed state (Treatment B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Vericiguat in People With Breast Cancer and Cancer Therapy-Related Cardiac Dysfunction
Status: RECRUITING
Conditions: Breast Cancer|Cardiac Dysfunction
Interventions: DRUG: Vericiguat|OTHER: Optimal medical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Dual Antiplatelet Therapy Study (DAPT Study)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Placebo & Aspirin|DRUG: Clopidogrel & Aspirin, Prasugrel & Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
Status: RECRUITING
Conditions: Hypertension|Hypertension, Systolic|Hypertension,Essential
Interventions: DEVICE: Medtronic Astra/Azure DR MRI IPG with AVIM therapy Activated|DEVICE: Medtronic Astra/Azure DR MRI IPG with AVIM therapy Deactivated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Gabapentin to Decrease Postoperative Delirium and Pain
Status: COMPLETED
Conditions: Postoperative Delirium|Postoperative Pain|Opioid Use|Hospital Length of Stay
Interventions: DRUG: Gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Efficacy and Safety of Lanreotide Autogel 120 MG in Treatment of Clinical Symptoms Associated With Inoperable Malignant Intestinal Obstruction
Status: COMPLETED
Conditions: Intestinal Obstruction
Interventions: DRUG: Lanreotide Autogel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nitazoxanide for the Treatment of Prolonged Diarrhea in Children
Status: COMPLETED
Conditions: Diarrhea
Interventions: DRUG: Nitazoxanide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BPH-6: Comparison of the UroLift System to TURP for Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: DEVICE: UroLift System|PROCEDURE: Transurethral Resection of the Prostate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention in Children With Malnutrition
Status: COMPLETED
Conditions: Overweight and Obesity|Stunted Growth|Malnutrition, Child|Nutrient Deficiency
Interventions: DIETARY_SUPPLEMENT: Experimental intervention group with enriched cookies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Using Family-Based Approaches to Improve Healthy Eating for Southeast Asian Children
Status: NOT_YET_RECRUITING
Conditions: Diet, Healthy
Interventions: BEHAVIORAL: Financial Incentives|BEHAVIORAL: Financial Incentives and Multilevel Multicomponent|OTHER: School Engagement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Different Intervention Models of Premature Infants Based on the ICF Biopsychosocial Model
Status: NOT_YET_RECRUITING
Conditions: Prematurity
Interventions: OTHER: Orientations for families|OTHER: Professional stimulation more orientations for families.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Temporary Celiac Ganglion Block as a Test Before Celiac Ganglion Resection for Dysautonomia-Related Bowel Dysmotility
Status: COMPLETED
Conditions: Dysautonomia
Interventions: PROCEDURE: Celiac ganglion block|DRUG: Liposomal bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of TEV-50717 (Deutetrabenazine) for the Treatment of Dyskinesia in Cerebral Palsy in Children and Adolescents
Status: COMPLETED
Conditions: Cerebral Palsy, Dyskinetic
Interventions: DRUG: TEV-50717|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seronegative Chronic Lyme Disease
Status: COMPLETED
Conditions: Lyme Disease
Interventions: DRUG: ceftriaxone|DRUG: doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Triplex Checkpoint Inhibitors Therapy for Advanced Solid Tumors
Status: RECRUITING
Conditions: Lung Cancer|Liver Cancer|Colorectal Cancer|Pancreas Cancer|Ovary Cancer|Head and Neck Cancer|Breast Cancer|Gastric Cancer|Cervical Cancer|Esophageal Cancer|Sarcoma
Interventions: DRUG: ipilimumab +pembrolizumab +durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anterior Component Separation Versus Posterior Component Separation for Repair of Large Ventral Hernias
Status: RECRUITING
Conditions: Large Midline Ventral Hernia
Interventions: PROCEDURE: Anterior component separation|PROCEDURE: Posterior component separation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of SY-1425 (Tamibarotene) in Combination With Azacitidine and Venetoclax for Patients With Chronic Myelomonocytic Leukemia
Status: WITHDRAWN
Conditions: Chronic Myelomonocytic Leukemia
Interventions: DRUG: Azacitidine|DRUG: Tamibarotene|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Follow-up Investigation of Efficacy of Ragweed MATAMPL,and Placebo in Patients With Ragweed-induced Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Type I Hypersensitivity
Interventions: BIOLOGICAL: Ragweed MATAMPL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Monoclonal Antibodies in Detecting Residual Disease in Patients Who Have Been Treated for Non-Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: PROCEDURE: immunoscintigraphy|RADIATION: technetium Tc 99m epratuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Tolerability, Safety, Pharmacokinetics and Pharmacodynamics of TQA3810 Tablets
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: TQA3810
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of the New dHER2 Vaccine to Treat HER2-positive Metastatic Breast Cancer
Status: COMPLETED
Conditions: Neoplasms, Breast
Interventions: BIOLOGICAL: GSK Biologicals' 719125
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 131I-Metaiodobenzylguanidine (131I-MIBG) Therapy for Relapsed/Refractory Neuroblastoma
Status: NO_LONGER_AVAILABLE
Conditions: Relapsed Neuroblastoma|Metastatic Pheochromocytoma
Interventions: DRUG: 131 I-Metaiodobenzylguanidine|DRUG: Potassium Iodide|DRUG: G-csf
Study Type: EXPANDED_ACCESS
Clinical trial: Lateral Versus Posterior Quadratus Lumborum Block in The Pediatric Patients Undergoing Orchiopexy
Status: COMPLETED
Conditions: Pain
Interventions: PROCEDURE: Lateral Quadratus Lumborum block|PROCEDURE: Posterior Quadratus Lumborum Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Split-face Study: Cosmetic Botulinum Toxin Type A Injection Under Electromyography-guidance Versus Conventional Palpation Technique
Status: COMPLETED
Conditions: Glabellar Frown Lines|Rhytides|Wrinkle|Facial Expression
Interventions: DEVICE: Electromyography-Needle Intramuscular Drug guidance|DRUG: Botulinum toxin type A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Structured Exercise Training Program Versus Hypocaloric Hyperproteic Diet in Obese Anovulatory Infertile Patients With PCOS
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Anovulation|Infertility
Interventions: BEHAVIORAL: Structured exercise training|BEHAVIORAL: Hypocaloric hyperproteic diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of Anacetrapib (MK-0859) When Added to Ongoing Statin Therapy in Japanese Participants With Heterozygous Familial Hypercholesterolemia (MK-0859-050)
Status: COMPLETED
Conditions: Heterozygous Familial Hypercholesterolemia (HeFH)
Interventions: DRUG: Anacetrapib|DRUG: Placebo for anacetrapib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of BHB Concentration Agreement Among Sampling Locations and the Impact of Ketosis on EPO, and More
Status: RECRUITING
Conditions: Ketosis
Interventions: DIETARY_SUPPLEMENT: Ketone monoester|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Midazolam Drug Interaction Study With PF-04171327
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: PF-04171327 25 mg|DRUG: Midazolam 2 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Efficacy of Reverse Hybrid Therapy and Bismuth Quadruple Therapy
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: pantoprazole+bismuth+tetra+metro|DRUG: (panto+amox+clar+metr)+(panto+amox)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: This Study Was a Prospective, One-arm Open Phase II Clinical Trial. A Systematic Review of the pCR of Apatinib in Combination With the Albumin Paclitaxel and Carboplatin Regimens for the Neoadjuvant Therapy of Triple-negative Breast Cancer, as Well as the Safety of Treatment
Status: UNKNOWN
Conditions: Systematic Review of the pCR Rate of Apatinib Combined With Albumin Paclitaxel and Carboplatin Regimen for Neoadjuvant Therapy of Triple-negative Breast Cancer
Interventions: DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Leukemia Stem Cell Detection in Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Acute Myeloid Leukemia (AML)
Interventions: PROCEDURE: Allogeneic HCT|DRUG: Consolidation chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Telerehabilitation on the Children With Cerebral Palsy and Their Caregivers
Status: UNKNOWN
Conditions: Cerebral Palsy
Interventions: OTHER: Telerehabilitation|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Single Ascending Dose Safety and Tolerability of NTS-104 Healthy Adults
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DRUG: NTS-104 TRIS|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Investigating the Pharmacokinetic Properties of NN1218 in Subjects With Diabetes Mellitus, Type 1
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: Faster-acting insulin aspart|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Scleroderma Treatment With Celution Processed Adipose Derived Regenerative Cells (STAR)
Status: COMPLETED
Conditions: Scleroderma|Systemic Sclerosis|Raynaud Phenomena|Raynaud's Disease
Interventions: DEVICE: Celution Device|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DAREON™-9: A Study to Test How Well Different Doses of BI 764532 Are Tolerated by People With Small Cell Lung Cancer When Taken Together With Topotecan
Status: RECRUITING
Conditions: Small Cell Lung Carcinoma (SCLC)
Interventions: DRUG: BI 764532|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Energy Drink on Cardiovascular Variables: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: OTHER: Energy drink|OTHER: Placebo drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Studying DNA in Tumor Tissue Samples From Patients With Localized or Metastatic Osteosarcoma
Status: COMPLETED
Conditions: Sarcoma
Interventions: GENETIC: DNA analysis|GENETIC: RNA analysis|GENETIC: gene expression analysis|GENETIC: gene rearrangement analysis|GENETIC: mutation analysis|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Trial of GSK3640254 + Dolutegravir (DTG) in Human Immunodeficiency Virus-1 Infected Treatment-naive Adults
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: GSK3640254|DRUG: Dolutegravir|DRUG: Lamivudine capsules|DRUG: Lamivudine tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Von Hippel-Lindau (VHL): Clinical Manifestations, Diagnosis, Management and Molecular Bases of Inherited Renal and Other Urologic Malignant Disorders
Status: RECRUITING
Conditions: Kidney Cancer|Urologic Malignant Disorders|Renal Cell Carcinoma|Familial Renal Cancer (FRC)|Clear Cell Renal Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Expanded Access Program to Provide Sugemalimab for the Treatment of Relapsed or Refractory Extranodal Natural Killer/T-Cell Lymphoma (R/R ENKTL)
Status: NO_LONGER_AVAILABLE
Conditions: Extranodal NK/T-cell Lymphoma
Interventions: DRUG: sugemalimab
Study Type: EXPANDED_ACCESS
Clinical trial: Interaction of Salivary Proteins and Polyphenols
Status: COMPLETED
Conditions: Diet Habit|Diet Modification|Taste, Altered|Saliva Altered
Interventions: OTHER: Chocolate Milk|OTHER: Chocolate milk substitute|OTHER: Chocolate milk substitute with gelatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Randomized Controlled Trial of IV Ketorolac to Prevent Post-ERCP Pancreatitis
Status: WITHDRAWN
Conditions: Pancreatitis
Interventions: DRUG: Ketorolac|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Testing Treatment With Encorafenib and Binimetinib Before Surgery for Melanoma With Lymph Node Involvement
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma of Unknown Primary|Metastatic Malignant Neoplasm in Lymph Node|Pathologic Stage IIIB Cutaneous Melanoma AJCC v8|Pathologic Stage IIIC Cutaneous Melanoma AJCC v8|Pathologic Stage IIID Cutaneous Melanoma AJCC v8|Recurrent Cutaneous Melanoma
Interventions: DRUG: Binimetinib|PROCEDURE: Computed Tomography|PROCEDURE: Conventional Surgery|DRUG: Encorafenib|OTHER: Fluorothymidine F-18|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of KX2-391 for Treatment of Bone-Metastatic, Castration-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Bone-Metastatic, Castration-Resistant Prostate Cancer
Interventions: DRUG: KX2-391
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of an Antimicrobial Utilization Program on Antimicrobial Use
Status: COMPLETED
Conditions: Antimicrobial Prescribing Practices
Interventions: BEHAVIORAL: Academic Detailing by the Antimicrobial Utilization Team (AUT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Rescue Carotid Stenting in Tandem Occlusions: 4-year Experience From a Comprehensive Stroke Centre
Status: COMPLETED
Conditions: Acute Stroke|Ischemic Stroke, Acute
Interventions: PROCEDURE: Rescue carotid stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK Study of Dapagliflozin in Pediatric Subjects With T2DM
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Dapagliflozin|DRUG: Dapagliflozin|DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Multimodal Cognitive Enhancement Therapy (MCET) for Ealy Dementia
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Dementia, Mild
Interventions: OTHER: Period I MCET (8 wks)|OTHER: Washout (4 wks)|OTHER: Period II MCET (8 wks)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OKN-007 in Combination With Adjuvant Temozolomide Chemoradiotherapy for Newly Diagnosed Glioblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: OKN 007|DRUG: Temozolomide|RADIATION: Photon/Proton IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abatacept Treatment in Polymyositis and Dermatomyositis
Status: COMPLETED
Conditions: Polymyositis|Dermatomyositis
Interventions: DRUG: Abatacept Active Treatment|DRUG: Abatacept Delayed-Onset Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ELVN-002 With Trastuzumab +/- Chemotherapy in HER2+ Solid Tumors, Colorectal and Breast Cancer
Status: RECRUITING
Conditions: HER2-positive Breast Cancer|HER2-positive Gastric Cancer|HER2 Positive Solid Tumors|HER2 Amplification|Colorectal Cancer
Interventions: DRUG: ELVN-002|DRUG: Trastuzumab|DRUG: 5-Fluorouracil|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Eribulin|DRUG: paclitaxel|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Pharmacokinetics, Safety and Tolerability of Dolutegravir and Rilpivirine (JULUCA™) 50 Milligram (mg)/25 mg Tablets in Healthy Subjects of Japanese Descent
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: JULUCA (Dolutegravir and Rilpivirine) 50mg/25mg FDC tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture as Treatment of Post-herpetic Neuralgia: A RCT A Double-blinded Randomized Clinical Trial.
Status: COMPLETED
Conditions: Post Herpetic Neuralgia
Interventions: PROCEDURE: Superficial dry needling / Acupunture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety and Efficacy of Astarabine in Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia
Interventions: DRUG: Astarabine (BST-236)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Two Metal Surface Finishes on Femoral Components in Hip Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: Femoral implant (Versys Fiber Metal Taper®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Pre-meal Snack and/or Exercise on Post-prandial Glycemic Excursions in Adults With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DIETARY_SUPPLEMENT: Snack beverage|BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Multicomponent Intervention to Promote Physical Activity Levels During the School Day (MOVESCHOOL)
Status: RECRUITING
Conditions: Physical Activity|Adolescents|Physical Fitness|Cognition
Interventions: BEHAVIORAL: Multicomponent school-based intervention.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Itraconazole in the Prevention of Histoplasmosis, a Fungal Infection, in HIV-Infected Patients
Status: COMPLETED
Conditions: HIV Infections|Histoplasmosis
Interventions: DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparison of CornerLoc SI Joint Stabilization and Steroid Injections for Sacroiliac Joint Dysfunction
Status: TERMINATED
Conditions: Sacroiliac Joint Somatic Dysfunction
Interventions: DEVICE: CornerLoc SI Joint Stabilization Procedure|DRUG: Intra-articular Sacroiliac Joint Steroid Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intraoperative Dexmedetomidine on Development of Acute Kidney Injury
Status: COMPLETED
Conditions: Malignant Tumor
Interventions: DRUG: Dexmedetomidine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ablation of Low Voltage Regions in Persistent Atrial Fibrillation
Status: UNKNOWN
Conditions: Persistent Atrial Fibrillation
Interventions: PROCEDURE: Low voltage ablation|PROCEDURE: Pulmonary Vein Isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Blood Flow Restriction Resistance Exercise in Lower Cervical Spinal Cord Injury Patients
Status: COMPLETED
Conditions: Cervical Spinal Cord Injury
Interventions: OTHER: Blood flow restriction|OTHER: Conventional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Crossover Post-herpetic Neuralgia (PHN)
Status: COMPLETED
Conditions: Post-Herpetic Neuralgia (PHN)
Interventions: DRUG: BMS-954561|DRUG: BMS-954561|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Functional Abdominal Distension by Non-instrumental Biofeedback
Status: RECRUITING
Conditions: Irritable Bowel Syndrome|Dyspepsia|Functional Bloating
Interventions: BEHAVIORAL: Biofeedback|BEHAVIORAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of ZP-Glucagon to Injectable Glucagon for Hypoglycemia
Status: COMPLETED
Conditions: Hypoglycemia
Interventions: DRUG: Glucagon (ZP-Glucagon)|DRUG: Glucagon (GlucaGen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Cesarean Childbirth Rates Using the Hem-Avert Perianal Stabilizer
Status: TERMINATED
Conditions: Cesarean Section
Interventions: DEVICE: Hem-Avert Perianal Stabilizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SQUEEZE Trial: A Trial to Determine Whether Septic Shock Reversal is Quicker in Pediatric Patients Randomized to an Early Goal Directed Fluid Sparing Strategy vs. Usual Care
Status: COMPLETED
Conditions: Septic Shock
Interventions: OTHER: Fluid Sparing Resuscitation Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Trial of Tazemetostat Plus CAR T Cell Therapy in B-cell Lymphomas
Status: RECRUITING
Conditions: Follicular Lymphoma|B-Cell Lymphoma|Mantle Cell Lymphoma|Diffuse Large B Cell Lymphoma
Interventions: DRUG: Tazemetostat Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Docosahexaenoic Acid (DHA) Metabolic Pathway in Human by Using 13C Labeled Molecules
Status: COMPLETED
Conditions: Healthy Subject
Interventions: DRUG: 13-C labeled AceDoPC-DHA|DRUG: 13-C labeled TG-DHA|DRUG: 13-C labeled PC-DHA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Outcome of SBO With Calcium Silicate Sealer vs WVC With Resin Based Sealer
Status: COMPLETED
Conditions: Root Canal Obturation|Root Canal Filling|Sealer-based Obturation|Randomized Clinical Trial|Postoperative Pain|Resin Based Sealer|Warm Vertical Compaction
Interventions: DEVICE: TotalFill Bioceramic Sealer|DEVICE: AH+ Sealer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Nexium on the Side Effects Associated With a Colonoscopy Prep
Status: COMPLETED
Conditions: Nausea|Vomiting|Abdominal Pain
Interventions: DRUG: esomeprazole (PPI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: 3-part Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of EXS21546
Status: COMPLETED
Conditions: Oncology
Interventions: DRUG: EXS21546 Powder for Oral Suspension|DRUG: EXS21546 Granule in Capsule|OTHER: Midazolam|OTHER: Food Effect|OTHER: Placebo Powder for Oral Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Markers in Exhaled Breath Condensate in Obstructive Sleep Apnoea (OSA) Patients
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: CPAP|DEVICE: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of ISIS EIF4E Rx in Combination With Carboplatin and Paclitaxel
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: ISIS EIF4E Rx|DRUG: ISIS EIF4E Rx|DRUG: ISIS EIF4E Rx|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recurrent and Nonrecurrent Condyloma Treatment
Status: TERMINATED
Conditions: Recurrent Condyloma|Nonrecurrent Condyloma
Interventions: DRUG: PROAPOPTOTIC PEPTIDE CIGB 300
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Early and Late Injection of Botulinum Toxin Type A on Upper Limb Function in Patients With Stroke
Status: RECRUITING
Conditions: Stroke
Interventions: DRUG: OnabotulinumtoxinA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DOT Diary Mobile App for Pre-Exposure Prophylaxis Adherence in Young Men
Status: COMPLETED
Conditions: Adherence, Medication|Risk Behavior|Pre-Exposure Prophylaxis|HIV Prevention
Interventions: DRUG: Emtricitabine / Tenofovir Disoproxil Oral Tablet|OTHER: DOT Diary mobile app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of the Acceptability, Feasibility and Effectiveness of Two Methods of Involvement of Patients With Cognitive Disability in Clinical Guidelines Development: a Randomized Crossover Pilot Trial
Status: UNKNOWN
Conditions: Brain Injury
Interventions: OTHER: Focus group|OTHER: Wiki
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH