pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: To Compare Blephapad Combo vs Standard Treatment for Eyelid Cleansing in Bilateral Posterior Blepharitis
Status: COMPLETED
Conditions: Bilateral Blepharitis (Disorder)
Interventions: COMBINATION_PRODUCT: Blephapad Combo|OTHER: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Sevoflurane Versus Isoflurane on Vasopressor Need
Status: TERMINATED
Conditions: Hypotension
Interventions: DRUG: Sevoflurane and isoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ph II Gemcitabine, Erlotinib, and Gemcitabine With Erlotinib/Elderly Patients W/ IIIB/IV NSCLC
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: erlotinib hydrochloride|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: JMT101 Combined With Osimertinib in Patients With Stage Ⅲb-Ⅳ Non-small Cell Lung Cancer (NSCLC) Characterized by Epithermal Growth Factor Receptor (EGFR) Common Mutations
Status: ACTIVE_NOT_RECRUITING
Conditions: Local Advanced or Metastatic NSCLC|Harboring EGFR Common Mutation
Interventions: DRUG: JMT101 Injection|DRUG: Osimertinib tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Modulation in Rheumatoid Arthritis (RA) - Influence of Adalimumab
Status: COMPLETED
Conditions: Arthritis, Rheumatoid|Pain|Fatigue
Interventions: DRUG: adalimumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: COVID-19 Vaccine Hesitancy Counseling Intervention for Pharmacists
Status: ENROLLING_BY_INVITATION
Conditions: COVID-19
Interventions: BEHAVIORAL: Standard implementation webinar and online training|BEHAVIORAL: Virtual facilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Immunogenicity Study of a SARS-CoV-2 (COVID-19) Variant Vaccine (mRNA-1273.351) in Naïve and Previously Vaccinated Adults
Status: COMPLETED
Conditions: COVID-19|COVID-19 Immunisation
Interventions: BIOLOGICAL: mRNA-1273|BIOLOGICAL: mRNA-1273.351
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dietary Intervention Replacing Carbohydrate With Protein and Fat Has Greater Effect on Peripheral Blood Mononuclear Cell Metabolites Than on Plasma Metabolites in Patients With Prediabetes or Type-2 Diabetes
Status: COMPLETED
Conditions: Prediabetes|Type-2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Dietary intervention-refined rice|DIETARY_SUPPLEMENT: Dietary intervention-whole grains and legumes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sharing Our Strength: A Research Study for Bone Marrow/Stem Cell Transplant Survivors
Status: COMPLETED
Conditions: Leukemia|Acute Leukemia|Acute Lymphocytic Leukemia|Multiple Myeloma|Hematological Cancers|Psychological Distress
Interventions: BEHAVIORAL: Writing A (Experimental informative writing)|BEHAVIORAL: Writing B (Experimental noninformative writing)|BEHAVIORAL: Writing C (Control informative writing)|BEHAVIORAL: Writing D (Control noninformative writing)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Platelet Rich Plasma on Lateral Epicondylitis
Status: COMPLETED
Conditions: Lateral Epicondylitis|Elbow Pain
Interventions: PROCEDURE: Platelet Rich Plasma|PROCEDURE: Whole Blood Injection|PROCEDURE: Saline Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of 2 Cycles of Induction Chemo With Abraxane, Cetuximab, Cisplatin, & 5-FU for Advanced Head and Neck Cancer
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Abraxane|DRUG: Cetuximab|DRUG: Cetuximab|DRUG: Cisplatin|DRUG: 5-FU|RADIATION: Radiation (Post induction)|DRUG: Cisplatin|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Specifying the Anti-inflammatory Effects of Ziltivekimab
Status: NOT_YET_RECRUITING
Conditions: Atherosclerosis|Inflammation
Interventions: DRUG: Ziltivekimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety & Efficacy of Sofosbuvir 400mg/Ledipasvir 90mg in the Treatment of Chronic Hepatitis C Adolescents
Status: UNKNOWN
Conditions: Hepatitis C Virus Infection, Response to Therapy of
Interventions: DRUG: 12 weeks (Sofosbuvir 400mg/Ledipasvir 90mg)|DRUG: 8 weeks (Sofosbuvir 400mg/Ledipasvir 90mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and PK of Intravenous (IV) ETI-204 Alone and in Presence of Ciprofloxacin in Adult Volunteers
Status: COMPLETED
Conditions: Inhalational Anthrax
Interventions: BIOLOGICAL: ETI-204|DRUG: Ciprofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Maintenance Targeted Therapy With or Without Stereotactic Body Radiation Therapy for Stage IV Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Stage IV Non-small Cell Lung Cancer
Interventions: RADIATION: SBRT+TKI|DRUG: TKI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Flonoltinib Maleate Tablets in the Treatment of Proliferative Bone Marrow Tumors
Status: UNKNOWN
Conditions: Myeloproliferative Neoplasm (MPN)|Myelofibrosis，MF
Interventions: DRUG: flonoltinib 25mg|DRUG: flonoltinib 50mg|DRUG: flonoltinib 100mg|DRUG: flonoltinib 150mg|DRUG: flonoltinib 225mg|DRUG: flonoltinib 325mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Predict + Protect Study: Exploring the Effectiveness of a Predictive Health Education Intervention on the Adoption of Protective Behaviors Related to ILI
Status: ACTIVE_NOT_RECRUITING
Conditions: Influenza|Influenza A|Influenza B|COVID-19|Respiratory Syncytial Virus (RSV)
Interventions: BEHAVIORAL: ILI Predictive Alerts, Reactive Content, and Proactive Content|BEHAVIORAL: ILI Predictive Alerts, Reactive Content|BEHAVIORAL: Proactive Content|BEHAVIORAL: No Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Transfer Modality Research Initiative - Bangladesh
Status: COMPLETED
Conditions: Improving Pre-school Anthropometric Status|Improving Household Food Security|Improving Maternal Nutrition Knowledge
Interventions: OTHER: Cash transfer|OTHER: Food transfer|OTHER: Food and cash transfer|BEHAVIORAL: Behavior Communication Change (BCC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Microbiota and Symptom Distress in Head and Neck Cancer Patients Receiving Radiotherapy
Status: NOT_YET_RECRUITING
Conditions: Oral Mucositis|Microbiota|Symptoms and Signs
Interventions: DIETARY_SUPPLEMENT: honey|DIETARY_SUPPLEMENT: propolis|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Clinical Effect of Low-Intensity Electromagnetic Field Neurostimulation in Fibromyalgia Syndrome Patients
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: Noninvasive cortical electrical stimulation|DEVICE: Sham treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Promote Innovation in Rural Integrated Telepsychiatry
Status: COMPLETED
Conditions: Bipolar Disorder|Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Telepsychiatry Collaborative Care|BEHAVIORAL: Telepsychiatry Enhanced Referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Mycophenolate Mofetil 250 mg Capsule, Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Mycophenolate Mofetil|DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bipolar Plasmakinetic TURP Vs Monopolar TURP in the Treatment of Lower Urinary Tract Symptoms
Status: COMPLETED
Conditions: Prostatic Hyperplasia|Lower Urinary Tract Symptoms|Transurethral Resection of Prostate
Interventions: DEVICE: Transurethral Resection of the Prostate (TURP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Endocuff With or Without AI-assisted Colonoscopy
Status: RECRUITING
Conditions: Colonic Adenoma|Colonic Polyp|Colonic Cancer
Interventions: DEVICE: Endocuff with AI|DEVICE: AI alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Biomarkers in Obese Patients With Knee Osteoarthritis; Weight Loss
Status: UNKNOWN
Conditions: Osteoarthrtis|Obesity
Interventions: DIETARY_SUPPLEMENT: Dietary Supplement: Dietary Supplement: Intensive dietary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Quantitative MRI Perfusion Methods With Quantitative PET Perfusion Imaging
Status: WITHDRAWN
Conditions: MRI Scans
Interventions: DRUG: Adenosine|DRUG: Regadenoson|DRUG: O-15 labeled radioactive water|DEVICE: MRI|DEVICE: PET Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Rescue Therapy for Helicobacter Pylori Infection
Status: RECRUITING
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Vonoprazan|DRUG: Bismuth Potassium Citrate|DRUG: Tetracycline|DRUG: Metronidazole|DRUG: Amoxicillin|DRUG: Rifabutin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Enisamium Iodide for the Treatment of Acute Respiratory Viral Infections, Including Influenza.
Status: COMPLETED
Conditions: Acute Respiratory Viral Infections|Human Influenza
Interventions: DRUG: Enisamium Iodide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phone-Based Based Walk With Ease Program for Adults With Arthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Arthritis|Gout|Fibromyalgia|Rheumatoid Arthritis|Osteoarthritis|Lupus Erythematosus, Systemic
Interventions: BEHAVIORAL: Phone-Based Walk With Ease
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of A. Lumbricoides on Pulmonary Aspergillosis Development
Status: RECRUITING
Conditions: COPD Exacerbation Acute|Ascaris Lumbricoides Infection|Chronic Pulmonary Aspergillosis
Interventions: DIAGNOSTIC_TEST: Interleukin-1B|DIAGNOSTIC_TEST: Interleukin-4|DIAGNOSTIC_TEST: Interleukin-6|DIAGNOSTIC_TEST: tumor necrosis factor - a|DIAGNOSTIC_TEST: interferon- gamma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Community Pharmacist-Involved Collaborative Care Model for the Management of Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Community pharmacist-involved collaborative care|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Change in Free 25(OH)D After High Dose in Vitamin D Deficient Postmenopausal Women
Status: COMPLETED
Conditions: Vitamin D Deficiency|Osteoporosis
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol (Vitamin D3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Endpoint Bioequivalence Study of "Oxymetazoline Hydrochloride Cream"
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: Oxymetazoline Hydrochloride|DRUG: Rhofade Cream, 1%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nailfold Capillary Blood Flow With Latanoprost Bunod
Status: COMPLETED
Conditions: Glaucoma, Open-Angle
Interventions: DRUG: Latanoprost 0.005%|DRUG: Latanoprost bunod 0.024%|DRUG: Normal saline 0.9%|DIAGNOSTIC_TEST: Nailfold capillaroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Impact of a "Serious Game" on Improving Patient's Medication Knowledge
Status: COMPLETED
Conditions: Health Knowledge, Attitudes, Practice
Interventions: BEHAVIORAL: MasterMed|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluating the Benefit of Concurrent Tricuspid Valve Repair During Mitral Surgery
Status: COMPLETED
Conditions: Mild Tricuspid Regurgitation|Moderate Tricuspid Regurgitation|Tricuspid Regurgitation
Interventions: PROCEDURE: TV Annuloplasty|PROCEDURE: MVS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Examination of Bromocriptine on Homeostatic and Hedonic Mechanisms of Food Intake in Individuals at High Risk for T2DM
Status: COMPLETED
Conditions: Overweight and Obesity|Eating Behavior
Interventions: DRUG: Placebo|DRUG: Bromocriptine-QR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability
Status: RECRUITING
Conditions: Metastatic Lung Small Cell Carcinoma|Metastatic Malignant Neoplasm in the Brain|Recurrent Lung Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: DRUG: Memantine Hydrochloride|OTHER: Neurocognitive Assessment|RADIATION: Stereotactic Radiosurgery|RADIATION: Whole-Brain Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Facilitating Patient Communication During Noninvasive Ventilation
Status: COMPLETED
Conditions: Noninvasive Ventilation|Speech Intelligibility
Interventions: DEVICE: Noninvasive Ventilation Mask Microphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Efficacy of Oral Famciclovir Versus Aciclovir Treatment in Patients With Herpes Zoster
Status: COMPLETED
Conditions: Herpes Zoster
Interventions: DRUG: Famciclovir|DRUG: Aciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Administration of Dexamethasone in PONV Prophylaxis in Children Undergoing Adenotomy
Status: COMPLETED
Conditions: Nasal Obstruction|Nasopharyngeal Obstruction|Snoring|Apnea, Obstructive|Hearing Loss|Otitis
Interventions: DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: COMPARISON OF LIVER RETRACTOR FOR INTRATOPERATIVE LIVER DAMAGE
Status: COMPLETED
Conditions: Liver Damage
Interventions: PROCEDURE: liver retraction Nathanson retractor|PROCEDURE: liver retraction snake retractor|PROCEDURE: liver retraction fan retractor|PROCEDURE: liver retraction laparoscopic grasper
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability and Efficacy on Low Density Lipoprotein Cholesterol (LDL-C) of Evolocumab in Participants With Human Immunodeficiency Virus (HIV) and Hyperlipidemia/Mixed Dyslipidemia
Status: COMPLETED
Conditions: Subjects With Hyperlipidemia, Dyslipidemia and HIV Infection
Interventions: DRUG: Evolocumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Local Excision Versus Total Mesorectal Excision In Pathological Complete Response (ypT0-1cN0) Mid- Or Low-Rectal Cancer After Neoadjuvant Therapy
Status: UNKNOWN
Conditions: Rectal Cancer|Surgery
Interventions: PROCEDURE: local excision|PROCEDURE: total mesorectal excision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Single Intravitreal Injection of Triamcinolone or Bevacizumab for the Treatment of Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Bevacizumab|DRUG: Triamcinolone acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Administration of Colloidal Silicon Dioxide in Tablet Dosage Form in Patients With Acute Diarrhea
Status: COMPLETED
Conditions: Diarrhoea;Acute
Interventions: DRUG: Carbowhite|DRUG: Carbowhite placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Real-World Vibration Feedback Gait Retraining on Gait Biomechanics in People With Chronic Ankle Instability
Status: COMPLETED
Conditions: Chronic Ankle Instability
Interventions: OTHER: Real-world vibration feedback gait retraining
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Desflurane and Sevoflurane on Postoperative Delirium in Elderly Patients
Status: RECRUITING
Conditions: Delirium|Postoperative Cognitive Dysfunction
Interventions: DRUG: Desflurane|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Medtronic's MOSAIC Bioprosthesis Versus Baxter Carpentier-Edwards SAV Porcine Valve
Status: COMPLETED
Conditions: Cardiac Valve Replacement
Interventions: DEVICE: Carpentier-Edwards SAV bioprostheses|DEVICE: Medtronic Mosaic bioprostheses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RIVastigmine In Vascular cognitivE Impairment
Status: COMPLETED
Conditions: Cognitive Impairment
Interventions: DRUG: Exelon (rivastigmine)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Intratumoral DC Immunotherapy With Gemcitabine & XRT in Unresectable Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Gemcitabine|PROCEDURE: Dendritic Cell Immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Beds for Kids Program on Child Sleep
Status: COMPLETED
Conditions: Insufficient Sleep Syndrome|Inadequate Sleep Hygiene|Child Behavior Problems|Emotional Stress
Interventions: OTHER: Beds for Kids program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability of ETC-1922159 as a Single Agent and in Combination With Pembrolizumab in Advanced Solid Tumours
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumors
Interventions: DRUG: ETC-1922159|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of NN1250 Versus Insulin Glargine in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec|DRUG: insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of LFG316 in Transplant Associated Microangiopathy (TAM) Patients
Status: TERMINATED
Conditions: Transplant Associated Microangiopathy TAM
Interventions: DRUG: LFG316 active drug|OTHER: Standard of care treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Haploidentical Transplantation With Early Adoptive Transfer of CD56+CD3- NK Cells
Status: UNKNOWN
Conditions: Acute Myeloid Leukemias|Advanced Hematological Malignancies|Indication for Allogeneic Stem Cell Transplantation|no HLA-identical Donor Available
Interventions: BIOLOGICAL: Haploidentical transplantation with donor NK cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Micafungin in Patients With Invasive Candidiasis or Candidemia
Status: COMPLETED
Conditions: Candidiasis|Candidemia
Interventions: DRUG: Micafungin|DRUG: Caspofungin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between Single and Double Limb Hip Spica Cast in Fracture Femur in Young Children
Status: COMPLETED
Conditions: Femur Fracture
Interventions: PROCEDURE: Placing a hip spica cast for patients with femur fractures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Intravitreal Ocriplasmin in Subjects With AMD With Focal Vitreomacular Adhesion
Status: COMPLETED
Conditions: Exudative Age-Related Macular Degeneration|Focal Vitreomacular Adhesion
Interventions: DRUG: Ocriplasmin|DRUG: Sham injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Xuebi Formula for Diabetic Peripheral Neuropathy(Qi-deficiency and Blood-stasis)
Status: UNKNOWN
Conditions: Diabetic Peripheral Neuropathy|Diabetes|Chinese Herbs
Interventions: DRUG: Xuebi formula|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Study Drug With Placebo and Haloperidol in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Lurasidone 20 mg|DRUG: Lurasidone 40mg|DRUG: Lurasidone 80 mg|DRUG: Haloperidol 10mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Charlson Comorbidity Index and Outcome of Cardiopulmonary Resuscitation in Geriatric Patients in Hong Kong
Status: COMPLETED
Conditions: Comorbidities and Coexisting Conditions|Cardiopulmonary Resuscitation|Geriatrics
Interventions: PROCEDURE: Cardiopulmonary resuscitation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Trial of Intravenous Vitamin C in Refractory Non-Hodgkin Lymphoma (NHL)
Status: TERMINATED
Conditions: Non-Hodgkin Lymphoma
Interventions: DRUG: Intravenous vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benefit of IQP-VV-102 in Reducing Postprandial Glucose Level in Overweight Caucasian Subjects
Status: COMPLETED
Conditions: Prediabetes|Hyperglycemia
Interventions: DEVICE: Dose 1 of IQP-VV-102|DEVICE: Dose 2 of IQP-VV-102|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Use of the GARDEX™ Embolic Protection Device During Percutaneous Coronary Interventions of Saphenous Vein Graft
Status: TERMINATED
Conditions: Saphenous Vein Graft Disease|Myocardial Ischemia|Embolism
Interventions: DEVICE: GARDEX™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Transmission of Cytomegalovirus (CMV) Infection From Mother to Foetus
Status: COMPLETED
Conditions: Infections, Cytomegalovirus|Cytomegalovirus Infections
Interventions: PROCEDURE: Blood sample|PROCEDURE: Cord blood sample|PROCEDURE: Saliva swab|PROCEDURE: Urine sampling|PROCEDURE: Vaginal swab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Computer-delivered Screening and Brief Intervention for Alcohol Use in Pregnancy
Status: COMPLETED
Conditions: Alcohol Abuse
Interventions: BEHAVIORAL: Nutrition time control/placebo intervention|BEHAVIORAL: Computer-delivered, brief intervention on alcohol use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: A Study to Assess the Pharmacokinetics of AZD6793 When Administered Alone and in Combination With Itraconazole in Healthy Participants.
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: AZD6793|DRUG: Itraconazole|DRUG: AZD6793+ Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Anti-Inflammatory Effects of Exercise and Peanut Consumption
Status: TERMINATED
Conditions: Peanut Consumption|High Intensity Aerobic Exercise
Interventions: OTHER: High Intensity Interval Training|OTHER: Peanut Consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mechanism of Action of Fluticasone Furoate in Childhood Obstructive Sleep Apnea Syndrome
Status: COMPLETED
Conditions: Childhood Obstructive Sleep Apnea Syndrome (OSAS)
Interventions: DRUG: fluticasone furoate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neoadjuvant Adebrelimab in Resectable SCLC: A Randomized Trial
Status: RECRUITING
Conditions: Small Cell Lung Cancer (SCLC)
Interventions: DRUG: Adebrelimab + Etoposide + Platinum-based Therapy|DRUG: Etoposide + Platinum-based Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Deep Carious Lesions With Selective Caries Removal, Partial or Full Pulpotomy
Status: NOT_YET_RECRUITING
Conditions: Irreversible Pulpitis|Reversible Pulpitis|Dentine Caries
Interventions: PROCEDURE: Selective Caries Removal with Biodentine™|PROCEDURE: Partial Pulpotomy with Biodentine™|PROCEDURE: Full Pulpotomy with Biodentine™|PROCEDURE: Direct composite filling after selective caries removal/full pulpotomy/partial pulpotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Intravitreal Aflibercept Injection for Persistent CRVO-associated Macular Edema Despite Prior Anti-VEGF Therapy
Status: UNKNOWN
Conditions: Retinal Vein Occlusion
Interventions: DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Corneal Graft Attachment in Patients With Fuchs Endothelial Corneal Dystrophy Following DMEK Using Ultra-high Resolution OCT
Status: COMPLETED
Conditions: Fuchs' Endothelial Dystrophy
Interventions: DEVICE: Ultrahigh resolution Spectral Domain OCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Influence of Probiotic Supplementation on Depressive Symptoms, Inflammation and Oxidative Stress Parameters and Faecal Microbiota in Patients With Depression Depending on Metabolic Syndrome Comorbidity
Status: UNKNOWN
Conditions: Depressive Disorder|Depression|Anxiety|Stress|Metabolic Syndrome|NAFLD
Interventions: DIETARY_SUPPLEMENT: Lactobacillus helveticus Rosell®-52, Bifidobacterium longum Rosell®-175|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreous Bevacizumab and Standard Metabolic Control for Diabetic Macular Edema - A Contrast Sensitivity Study
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: intravitreal bevacizumab injection(1.25mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Family-Focused Adolescent & Lifelong Health Promotion Phase 2
Status: NOT_YET_RECRUITING
Conditions: Adolescent - Emotional Problem|Parent-Child Relations|Family Functioning|Well-Being, Psychological
Interventions: BEHAVIORAL: Parenting for Lifelong Health for Parents and Teens (PLH)|BEHAVIORAL: Helping Adolescents Thrive comics|BEHAVIORAL: I Support My Friends
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Adaptive Dengue Antiviral Platform Trial
Status: NOT_YET_RECRUITING
Conditions: Dengue|Antiviral Drugs
Interventions: DRUG: Molnupiravir 400 mg|DRUG: VIS513 (a monoclonal antibody)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravesical Administration of rAd-IFN/Syn3 in Patients With BCG-Refractory or Relapsed Bladder Cancer
Status: COMPLETED
Conditions: Superficial Bladder Cancer
Interventions: DRUG: INSTILADRIN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Tipifarnib in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: etoposide|DRUG: tipifarnib|PROCEDURE: chemotherapy|PROCEDURE: enzyme inhibitor therapy|PROCEDURE: high-dose chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Tolerability of Two Formulations of Atorvastatin In Korean Adult With Hypercholesterolemia
Status: COMPLETED
Conditions: Dyslipidemia|Cardiovascular Disease|Hypercholesterolemia
Interventions: DRUG: Atorvastatin (Lipinon)|DRUG: Atorvastatin (Lipitor)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of Axitinib In Combination With Cisplatin And Capecitabine In Patients With Advanced Gastric Cancer
Status: COMPLETED
Conditions: Stomach Neoplasms|Advanced Gastric Cancer
Interventions: DRUG: axitinib|DRUG: capecitabine|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Validation of an Artificial Intelligence-based Biliary Stricture Navigation System in MRCP-based ERCP
Status: UNKNOWN
Conditions: Gastrointestinal Disease|Endoscopy|Artificial Intelligence|Endoscopic Retrograde Cholangiopancreatography
Interventions: DEVICE: Artificial intelligence assistant system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Functional Test to Assess Fluid Status During Lung Protective Ventilation Strategies
Status: UNKNOWN
Conditions: Patients Receiving Protective Lung Ventilation|Patients in Grey Zone (3 < Pulse Pressure Variation (PPV) < 17
Interventions: DIAGNOSTIC_TEST: lung recruitment maneuver
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Post-Operative Pain in Cerebral Palsy (POPPIES) Trial
Status: COMPLETED
Conditions: Cerebral Palsy|Post-operative Pain
Interventions: DRUG: botulinum toxin intramuscular injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of BT086 to Evaluate Adjunctive Therapy in sCAP
Status: COMPLETED
Conditions: Community Acquired Pneumonia
Interventions: DRUG: BT086|DRUG: 1% Human Albumin infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topically Applied IDP-118 Lotion and HP Monad Lotion in Subjects With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: IDP-118 Lotion|DRUG: HP Monad Lotion|DRUG: Ultravate Cream|DRUG: Tazorac Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Registry for Adults With Plasma Cell Disorders (PCD's)
Status: RECRUITING
Conditions: Multiple Myeloma|Amyloidosis|Cryoglobulinemia|Castleman's Disease|Light Chain Deposition Disease|Heavy Chain Deposition Disease|Polyneuropathy Organomegaly Endocrinopathy Monoclonal Gammopathy and Skin Changes|Smoldering Multiple Myeloma|Plasma Cell Leukemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Plant Extracts on Semen Quality
Status: COMPLETED
Conditions: Poor Semen Quality
Interventions: DIETARY_SUPPLEMENT: Extracts of Punica granatum and Alpinia galanga|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Dose Escalation Study of VS-4718 in Subjects With Metastatic Non-Hematologic Malignancies
Status: TERMINATED
Conditions: Non Hematologic Cancers|Metastatic Cancer
Interventions: DRUG: VS-4718
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Two Surgical Techniques Using the Unity Knee™ Total Knee System
Status: WITHDRAWN
Conditions: Osteoarthritis, Knee|Rheumatoid Arthritis|Post-Traumatic Osteoarthritis of Knee|Varus Deformity, Not Elsewhere Classified, Knee|Valgus Deformity, Not Elsewhere Classified, Knee|Flexion Deformity, Knee|Fracture of Distal End of Femur|Fracture of Upper End of Tibia
Interventions: DEVICE: Unity Knee™ TKR using measured resection|DEVICE: Unity Knee™ TKR using ligament balancing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Staple-line Reinforcement for Prevention of Pulmonary Air Leakage
Status: COMPLETED
Conditions: Lung Neoplasms|Pulmonary Surgical Procedures|Surgical Staplers|Tissue Adhesives|Chest Tubes
Interventions: DEVICE: FOREseal|DEVICE: Stapling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Primary Vaccination Study With a Pneumococcal Conjugate Vaccine in Healthy Children 6-12wks of Age
Status: COMPLETED
Conditions: Infections, Streptococcal
Interventions: BIOLOGICAL: Pneumococcal conjugate vaccine GSK1024850A (different lots)|BIOLOGICAL: Infanrix hexa|BIOLOGICAL: Infanrix-IPV/Hib|BIOLOGICAL: Rotarix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Investigate the Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Response of SLN124 in Adults With Alpha/Beta-thalassaemia and Very Low- and Low-risk Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Non-transfusion-dependent Thalassemia|Low Risk Myelodysplastic Syndrome|Very-Low Risk Myelodysplastic Syndrome
Interventions: DRUG: SLN124|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Placebo-Controlled Study of Leptin for the Treatment of HIV Lipodystrophy and Metabolic Syndrome
Status: COMPLETED
Conditions: HAART-induced Lipodystrophy and Metabolic Syndrome
Interventions: DRUG: r-metHuLeptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of GSK Biological's Candidate Tuberculosis Vaccine Mtb72F/AS02A in Healthy PPD-positive Adults
Status: COMPLETED
Conditions: Tuberculosis (TB)
Interventions: BIOLOGICAL: Mtb72F/AS02A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Personalized Mechanical Ventilation Guided by UltraSound in Patients With Acute Respiratory Distress Syndrome
Status: RECRUITING
Conditions: ARDS, Human|Lung Ultrasound|Mechanical Ventilation
Interventions: OTHER: Personalized ventilation|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prostate Embolization for Massive Benign Prostatic Hypertrophy (BPH)
Status: TERMINATED
Conditions: Benign Prostatic Hypertrophy|Lower Urinary Tract Symptoms
Interventions: DEVICE: Embosphere microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Flow-cytometry Approaches to Improve the Detection of Tumor Cells in CTCL
Status: RECRUITING
Conditions: Cutaneous T-Cell Lymphoma
Interventions: DIAGNOSTIC_TEST: Detection and quantitation of (blood) tumor cells in patients with mycosis fungoides (MF) / Sézary syndrome (SS).
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Negative Pressure Wound Therapy in Obese Gynecologic Oncology Patients
Status: COMPLETED
Conditions: Postoperative Complications|Obesity|Gynecologic Neoplasms
Interventions: PROCEDURE: Standard Wound Closure|DEVICE: Prevena™ Incision Management System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough
Status: RECRUITING
Conditions: Refractory Chronic Cough
Interventions: DRUG: Duloxetine 30 MG|DRUG: Duloxetine 60 MG|DRUG: Amitriptyline 25 MG|DRUG: Amitriptyline 50 MG|DRUG: Placebo 30 MG|DRUG: Placebo 60 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Donor Versus Autologous Fecal Microbiota Transplantation for Irritable Bowel Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Irritable Bowel Syndrome
Interventions: BIOLOGICAL: Fecal microbiota transplantation (FMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral and Dermal Tolerability Clinical Study of an Experimental Denture Wipe
Status: COMPLETED
Conditions: Denture Cleansers
Interventions: DEVICE: Experimental Denture Wipe|OTHER: Tap Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study to Assess Beta-Lactam in the Treatment of Hospitalized Patients With Bacterial Pneumonia
Status: COMPLETED
Conditions: Pneumonia, Bacterial
Interventions: DRUG: Ceftriaxone|DRUG: beta-lactam|DRUG: beta-lactam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stanford Accelerated Recovery Trial (START)
Status: TERMINATED
Conditions: Pain|Breast Cancer|Lung Cancer
Interventions: DRUG: Gabapentin|DRUG: Lorazepam (active control)|DRUG: Placebo (inactive)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intensive Versus Standard Treatment for Hypotension on Maternal Hemodynamics in Preeclamptic Patients
Status: NOT_YET_RECRUITING
Conditions: Adverse Effect
Interventions: DRUG: Alpha-Agonist|DRUG: α-adrenergic receptor agonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Test How Effective and Safe GLPG1690 is for Participants With Idiopathic Pulmonary Fibrosis (IPF) When Used Together With Standard of Care
Status: TERMINATED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: GLPG1690|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SH T00186 in the Treatment of Primary Dysmenorrhea
Status: COMPLETED
Conditions: Primary Dysmenorrhea
Interventions: DRUG: Drug: YAZ flex (SH T00186D)|DRUG: YAZ (SH T00186D)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0031, ZD 1839 in Treating Patients With Advanced Cancer of the Urinary Tract
Status: COMPLETED
Conditions: Bladder Cancer|Transitional Cell Cancer of the Renal Pelvis and Ureter|Urethral Cancer
Interventions: DRUG: gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise Prescription for the Improvement of Quality of Life in Elderly Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Plasma Cell Myeloma
Interventions: OTHER: Exercise Counseling|BEHAVIORAL: Exercise Intervention|OTHER: Questionnaire administration|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety, Tolerability and PK Study of Single Doses of ABT-450 With and Without Ritonavir to Treat Hepatitis C Virus (HCV) Genotype 1
Status: COMPLETED
Conditions: HCV Infection
Interventions: DRUG: ABT-450|DRUG: ritonavir|DRUG: placebo for ABT-450|DRUG: Placebo for ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Maximizing Benefit of Lung Cancer Screening Incidental Findings of Cardiovascular, Respiratory and Breast Measures
Status: NOT_YET_RECRUITING
Conditions: Coronary Disease|Emphysema or COPD|Breast Density
Interventions: OTHER: System implementation of patient-centered incidental findings report
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Abemaciclib in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Abemaciclib|DRUG: Placebo|DRUG: Loperamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase I, Two-part Study to Determine the Recommended Dose and Evaluate the Safety and Tolerability of a Novel Oral Arsenic Trioxide Formulation (ORH-2014) in Subjects With Advanced Hematological Disorders
Status: COMPLETED
Conditions: Advanced Hematological Disorders
Interventions: DRUG: ORH-2014|DRUG: ORH-2014
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT