pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluation of Geistlich Fibro-Gide ® and Autogenous Connective Tissue Graft Prior to Orthodontic Maxillary Expansion.
Status: WITHDRAWN
Conditions: Thin Gingiva|Transverse Maxillary Deficiency|Cross Bite
Interventions: PROCEDURE: Gingival Phenotype Modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: G1T38, a CDK 4/6 Inhibitor, in Combination With Fulvestrant in Hormone Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Ductal, Breast|Breast Cancer|Breast Neoplasm
Interventions: DRUG: G1T38|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of a Flavonoids- and omega3s-based Compound for the Treatment of Muscular Dystrophies
Status: COMPLETED
Conditions: Muscular Dystrophies|Muscle Inflammation
Interventions: DIETARY_SUPPLEMENT: Flavonoids, DHA, EPA|DIETARY_SUPPLEMENT: placebo compound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Effectiveness of Benralizumab to Treat Patients With Severe Uncontrolled Asthma.
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Benralizumab (Medi-563)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nutritional Supplementation of Flavonoids Quercetin and Curcumin for Early Mild Symptoms of COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Standard of care|DIETARY_SUPPLEMENT: Investigational treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Daily Rifapentine for Pulmonary Tuberculosis
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: Rifapentine 450|DRUG: Rifapentine 600|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Benefits of Vitamin B Combination as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient
Status: UNKNOWN
Conditions: Painful Diabetic Neuropathy
Interventions: DRUG: Standard therapy|DRUG: Vitamin B combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Receiving Painless Gastrointestinal Endoscopy in the Morning or Afternoon on Postoperative Sleep Quality
Status: UNKNOWN
Conditions: Morning Inspections|Afternoon Inspections|Sleep Quality|Gastrointestinal Endoscopy|Pain|General Anesthesia
Interventions: PROCEDURE: Receive gastrointestinal endoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries|Neuropathic Pain
Interventions: DRUG: EC5026 oral tablet|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cells for the Treatment of Perianal Fistulizing Crohn's Disease
Status: UNKNOWN
Conditions: Perianal Crohn Disease|Perianal Fistula|Crohn Disease
Interventions: DRUG: Mesenchymal Stem Cells|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: New Clinical Rehabilitation Approach for the Management of Falls Risks
Status: NOT_YET_RECRUITING
Conditions: Musculoskeletal Diseases|Chronic Disease|Fall Patients|Aging Problems|Postural Low Back Pain|Parkinson Disease
Interventions: OTHER: OTAGO exercises|OTHER: Conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Glucose Control by eMPC Algorithm in Peri- and Postoperative Period in Cardiac Surgery Patients
Status: COMPLETED
Conditions: Cardiac Surgery Patients|Blood Glucose
Interventions: PROCEDURE: insulin infusion rate controled by computer algorithm|PROCEDURE: insulin infusion rate guided by in-house glucose management protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Listening to Stories and Watching Cartoon Film on Pain in the Aspiration Process in Children Receiving Palliative Care
Status: COMPLETED
Conditions: Aspiration; Syndrome
Interventions: OTHER: Listening to fairy tales|OTHER: Watching Cartoon Film
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: GENErating Behavior Change, An Integrative Health Coaching and Genetic Risk Testing Pilot
Status: COMPLETED
Conditions: Coronary Heart Disease Risk
Interventions: BEHAVIORAL: Health Coaching|GENETIC: 9p21|OTHER: Standard Risk Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase Ib Trial of MVA-EBNA1/LMP2 Vaccine in Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Nasopharyngeal Cancer|Epstein Barr Virus Infections
Interventions: DRUG: MVA-EBNA1/LMP2 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Optimum Dose of Remifentanil for Intubation in Small Children
Status: COMPLETED
Conditions: Endotracheal Intubation
Interventions: DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D3 Supplementation and Stress Fracture Occurrence in High-Risk Collegiate Athletes
Status: COMPLETED
Conditions: Vitamin D Deficiency|Stress Fracture|Athletic Injuries|Orthopedic Disorder
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol (Vitamin D3)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Fractional Bi-Polar RF for Symptoms of SUI and Vulvovaginal Atrophy
Status: COMPLETED
Conditions: Stress Urinary Incontinence|Vulvovaginal Signs and Symptoms
Interventions: DEVICE: MorpheusV Applicator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Liver Fibrosis Stage Assessment by Fibroblast Activation Protein Imaging in Patients With Biopsy for Suspected or Proven Nonalcoholic Steatohepatitis
Status: NOT_YET_RECRUITING
Conditions: Non-alcoholic Steatohepatitis
Interventions: DRUG: PET scan of 68Ga-FAPI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Amifostine in Treating Peripheral Neuropathy in Patients Who Have Received Chemotherapy for Cancer
Status: COMPLETED
Conditions: Gestational Trophoblastic Tumor|Neurotoxicity|Peripheral Neuropathy|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: amifostine trihydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intranasal Ketamine as an Adjunct to Fentanyl for the Prehospital Treatment of Acute Traumatic Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Traumatic Pain
Interventions: DRUG: Ketamine Hydrochloride|DRUG: Placebo-Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Clinical Study to Assess Pain Score and Wound Healing Following Fractional Ablation With a DFG Laser and CO2 Laser
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DEVICE: DFG Laser|DEVICE: CO2 Laser|DEVICE: Optical coherence tomography (OCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of SNDX-5613 in Combination With Intensive Chemotherapy in Participants With Acute Myeloid Leukemias
Status: RECRUITING
Conditions: Acute Myeloid Leukemias
Interventions: DRUG: SNDX-5613|DRUG: Chemotherapy Regimen|DRUG: HiDAC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemoradiation With Nal-IRI and Capecitabine Guided by UGT1A1 Status in Patients With Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer
Interventions: DRUG: liposomal irinotecan|DRUG: Capecitabine|RADIATION: Radiation threapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Stress-obesity Axis: a Metabolomics Approach Towards Personalized Nutrition in Adolescents
Status: RECRUITING
Conditions: Pediatric Obesity
Interventions: OTHER: Collection of anthropometric data, biological samples (stool, saliva and hair), questionnaires (demographic data, psychological data, medical data)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetics of Posaconazole in Children With Chronic Granulomatous Disease (CGD)
Status: COMPLETED
Conditions: Chronic Granulomatous Disease
Interventions: DRUG: posaconazole (PSZ)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Surufatinib Combined With Chemotherapy Plus Toripalimab or Not in the Treatment of Small Cell Lung Cancer
Status: RECRUITING
Conditions: Small Cell Lung Carcinoma
Interventions: DRUG: Surufatinib,Etoposide,Cisplatin,Toripalimab|DRUG: Surufatinib,Etoposide,Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety, Pharmacokinetics, and Antiviral Activity of Repeat Doses of GSK2878175 in Subjects With Chronic Hepatitis C.
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: GSK2878175|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Reinduction Chemotherapy Containing Carboplatin and Paclitaxel With or Without Epoetin Alpha in Recurrent Platinum Sensitive Ovarian Cancer, Cancer of the Fallopian Tube or Peritoneum
Status: TERMINATED
Conditions: Epithelial Ovarian Cancer, Fallopian Tube or Peritoneum|Platinum Sensitve Relapse|Anemia
Interventions: DRUG: paclitaxel, carboplatin, epoetin alpha
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Treatment Effects of Combination Therapy of Lucentis Plus Reduced Fluence PDT With Visudyne in Patients With Exudative AMD
Status: UNKNOWN
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: reduced fluence photodynamic therapy with Visudyne|DRUG: Lucentis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nordic Bifurcation Study. How to Use Drug Eluting Stents (DES) in Bifurcation Lesions?
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Percutaneous coronary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Pain Modulation by Intravenous Esketamine in CRPS
Status: ENROLLING_BY_INVITATION
Conditions: Complex Regional Pain Syndromes|CRPS (Complex Regional Pain Syndromes)
Interventions: DRUG: S-ketamine infusion inpatient setting|DRUG: S-ketamine infusion outpatient setting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Choline Nutritional Status: Development of a Biomarker Panel
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: 25% Cho diet|OTHER: 50% Cho diet|OTHER: 100% Cho diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Oxytocin Treatment of Social Cognitive and Functional Deficits in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Intranasal Oxytocin Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Project ADHERE: Clinical Proof-of-Concept of a Tenofovir (TFV) Aptamer-Based Biosensor
Status: COMPLETED
Conditions: HIV/AIDS|Adherence, Medication|Drug Use
Interventions: DRUG: Tenofovir Disoproxil Fumarate/Emtricitabine (TDF/FTC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Financial Incentives for Veteran Therapy Completion
Status: ACTIVE_NOT_RECRUITING
Conditions: Motivation|Stress Disorder|Post Traumatic Stress Disorder|Depression|Depressive Disorder
Interventions: BEHAVIORAL: Financial Incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Nicotine on Arousal, Cognition and Social Cognition in Schizophrenic Patients
Status: COMPLETED
Conditions: Schizophrenia|Cognition Disorders
Interventions: OTHER: A643 (nicotine)|OTHER: A643 (nicotine)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Performance of Neurally Adjusted Ventilatory Assist (NAVA) During Spontaneous Breathing Trial
Status: COMPLETED
Conditions: Respiratory Failure
Interventions: PROCEDURE: SBT- PSV|PROCEDURE: SBT - NAVA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility Disorders
Status: UNKNOWN
Conditions: Achalasia
Interventions: PROCEDURE: Per Oral Endoscopic Myotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Clinical Utility Trial for the SomaLogic CVD-T2D Test
Status: COMPLETED
Conditions: Cardiovascular Diseases|Type 2 Diabetes
Interventions: OTHER: Educational Materials on the Cardiovascular Disease in Type 2 Diabetes (CVD-T2D)|OTHER: Educational Materials on the CVD-T2D and Bundled Metabolic Panel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacist-led Group Medical Visits to Help With Diabetes Management
Status: COMPLETED
Conditions: Diabetes Mellitus|Cardiovascular Diseases
Interventions: OTHER: Algorithm driven medication titration|BEHAVIORAL: Monitoring|BEHAVIORAL: Group support|BEHAVIORAL: Self efficacy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: [F-18] RGD-K5 Positron Emission Tomography (PET) in Participants With Carotid Artery Stenosis
Status: TERMINATED
Conditions: Carotid Stenosis
Interventions: DRUG: [F-18]RDG-K5
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: The Use of Propranolol to Block Memory Reconsolidation in PTSD
Status: TERMINATED
Conditions: Posttraumatic Stress Disorders
Interventions: DRUG: Propranolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Patient's Risk Profile Using the Peri-implantitis Risk Diagram
Status: COMPLETED
Conditions: Peri-Implantitis|Peri-implant Mucositis|Dental Implant Failed
Interventions: DIAGNOSTIC_TEST: Evaluation of the patient's pre- and post-treatment risk profile using the peri-implantitis risk diagram
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: High vs.Standard Dose Influenza Vaccine in Pediatric Solid Organ Transplant (SOT) Recipients
Status: NOT_YET_RECRUITING
Conditions: Immunization; Infection|Transplantation Infection|Influenza
Interventions: BIOLOGICAL: Standard Dose Quadrivalent Inactivated Influenza Vaccine|BIOLOGICAL: High Dose Quadrivalent Inactivated Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Efficacy and Safety of Ublituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkins Lymphoma|B-cell Lymphoma|Waldenstrom's Macroglobulinemia|Marginal Zone Lymphoma|Chronic Lymphocytic Leukemia (CLL)|Small Lymphocytic Lymphoma (SLL)|Primary Central Nervous System Lymphoma
Interventions: DRUG: Ublituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Relaxation and Intensified Patient Surgery Education in Patients Undergoing Cholecystectomy
Status: UNKNOWN
Conditions: Gall Stones
Interventions: BEHAVIORAL: relaxation program|BEHAVIORAL: surgery education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Recalcitrant Neovascular AMD Using Brolocizumab With Immediate T&E
Status: COMPLETED
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: Brolucizumab|DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Testing a Novel Therapeutic Strategy for Comorbid Post-Traumatic Stress Disorder and Alcohol Use Disorder
Status: RECRUITING
Conditions: Stress Disorders, Post-Traumatic|Alcohol Use Disorder
Interventions: DRUG: Propranolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Assess the Bioequivalence of Two Pacritinib Drug Product Formulations and FMI Formulation Following Oral Administration in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Treatment A: 400 mg Pacritinib P3CT|DRUG: Treatment B: 400 mg of pacritinib FMI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Treatment Free Remission After Combination Therapy with Ruxolitinib Plus Tyrosine Kinase Inhibitors
Status: RECRUITING
Conditions: Chronic Phase Chronic Myeloid Leukemia|Chronic Myeloid Leukemia, Chronic Phase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib With Everolimus Versus Cabozantinib for Second-Line or Third-Line Treatment of Metastatic Renal Cell Cancer
Status: RECRUITING
Conditions: Advanced Clear Cell Renal Cell Carcinoma|Metastatic Clear Cell Renal Cell Carcinoma|Stage III Renal Cell Cancer AJCC v8|Stage IV Renal Cell Cancer AJCC v8
Interventions: DRUG: Cabozantinib|DRUG: Everolimus|DRUG: Lenvatinib|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Clinical Evaluation to Characterize in Vivo Effects of Topically Applied ZuraPrep & ZuraPrep Vehicle
Status: COMPLETED
Conditions: Surgical Site Infection
Interventions: DRUG: ZuraPrep with 70% IPA|DRUG: ZuraPrep without 70% IPA|DRUG: ChloraPrep CHG/IPA Teal Tint|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Posterior Urethrovesical Anastomotic Reconstruction in Comparison to Conventional Urethrovesical Anastomosis
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: Posterior reconstruction urethrovesical anastomosis.|PROCEDURE: Conventional vesicourethral anastomosis.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Radiation and Cisplatin Induced Toxicities With Tempol
Status: UNKNOWN
Conditions: Mucositis|Nephrotoxicity|Ototoxicity
Interventions: DRUG: Tempol|DRUG: Placebo Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AZD0530 in Treating Patients With Prostate Cancer That Did Not Respond to Hormone Therapy
Status: COMPLETED
Conditions: Hormone-resistant Prostate Cancer|Recurrent Prostate Cancer
Interventions: DRUG: saracatinib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Combination Therapy vs Placebo for Pediatric Functional Abdominal Pain
Status: WITHDRAWN
Conditions: Functional Abdominal Pain|Irritable Bowel Syndrome|Functional Dyspepsia
Interventions: DRUG: Melatonin, Peppermint Oil (mentharil), and Simethicone|OTHER: Sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intracoronary Stenting and Angiographic Results: Optimizing Treatment of Drug Eluting Stent In-Stent Restenosis 4
Status: COMPLETED
Conditions: Restenosis|Stable Angina Pectoris|Acute Coronary Syndrome
Interventions: DEVICE: Paclitaxel Eluting Balloon + Scoring Balloon|DEVICE: Paclitaxel Eluting Balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tenofovir Alafenamide for HBV Prophylaxis in Post Orthotopic Liver Transplant
Status: UNKNOWN
Conditions: HBV|POST LIVER TRANSPLANT
Interventions: DRUG: Tenofovir Alafenamide 25 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention Trial to Decrease Cardiovascular Risk in Persons With Serious Mental Illness
Status: COMPLETED
Conditions: Cardiovascular Risk Factors|Serious Mental Illness
Interventions: OTHER: IDEAL intervention|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Irinotecan, Capecitabine and Bevacizumab in Metastatic Colorectal Cancer Patients
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Capecitabine+Irinotecan+Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fentanyl Transdermal Matrix Patch ZR-02-01 to Treat Chronic, Moderate to Severe Osteoarthritis (OA) Pain
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: ZR-02-01 Fentanyl Transdermal Matrix Patch|DRUG: Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Co-administration of Olodaterol Respimat® and Tiotropium Handihaler®
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium|DRUG: Placebo matching Olodaterol|DRUG: Olodaterol|DRUG: Tiotropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract
Status: UNKNOWN
Conditions: Cancer of Upper Aerodigestive Pathways|Cachexia
Interventions: PROCEDURE: carcinological surgery|PROCEDURE: cervical surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preventive Application of GnRH Antagonist on Early OHSS
Status: UNKNOWN
Conditions: Ovarian Hyperstimulation Syndrome|GnRH Antagonist|Aspirin|Vascular Endothelial Growth Factor|Pigment Epithelium Derived Factor
Interventions: DRUG: GnRH antagonist|DRUG: aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Management of Skin Graft Donor Site Wound in Aged Patient
Status: COMPLETED
Conditions: Skin Regrafting; Donor Site of Skin Grafting; Vancouver Scar Scale
Interventions: PROCEDURE: skin graft|PROCEDURE: no skin graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: S9031-S9126-S9333-S9500-A, Studying Bone Marrow and Blood Samples From Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: GENETIC: DNA analysis|GENETIC: DNA methylation analysis|GENETIC: RNA analysis|GENETIC: gene expression analysis|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of 89Zr-DFO-MSTP2109A in Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: 89Zr- DFO-MSTP2109A|DRUG: 89Zr DFO-MSTP2109A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 1 Study of ADI-001 in B Cell Malignancies
Status: RECRUITING
Conditions: Lymphoma, Follicular|Lymphoma, Mantle-Cell|Marginal Zone Lymphoma|Primary Mediastinal B-cell Lymphoma|Diffuse Large B Cell Lymphoma|Lymphoma, Non-Hodgkin
Interventions: GENETIC: ADI-001|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) Pediatric Patients
Status: TERMINATED
Conditions: Steatohepatitis, Nonalcoholic|Hemosiderosis|Overweight Adolescents|Obesity, Childhood|Liver Steatosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Optic Neuritis With Erythropoietin: a Randomised, Double-blind, Placebo-controlled Trial
Status: COMPLETED
Conditions: Optic Neuritis
Interventions: DRUG: Erythropoietin alfa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Combination of Cetuximab and Radiotherapy Added to the Standard Treatment for Oesophageal Adenocarcinoma
Status: TERMINATED
Conditions: Resectable Esophageal Cancer
Interventions: DRUG: cetuximab|RADIATION: radiotherapy to oesophageal tumour
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cemiplimab Before and After Surgery for the Treatment of High Risk Cutaneous Squamous Cell Cancer
Status: RECRUITING
Conditions: Metastatic Skin Squamous Cell Carcinoma|Recurrent Skin Squamous Cell Carcinoma
Interventions: BIOLOGICAL: Cemiplimab|RADIATION: Radiation Therapy|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Alirocumab on Lipid Metabolism in Adults With Elevated LDL-Cholesterol
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: alirocumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Pazopanib on Bleeding in Subjects With Hereditary Haemorrhagic Telangiectasia
Status: TERMINATED
Conditions: Telangiectasia, Hereditary Hemorrhagic
Interventions: DRUG: Pazopanib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Effectiveness Study of Implementing Prism Adaptation as a Treatment for Spatial Neglect After Stroke
Status: COMPLETED
Conditions: Sensory Neglect|Stroke
Interventions: BEHAVIORAL: Prism Goggles|OTHER: Non-Shifting Goggles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Applying an Osteopathic Intervention to Improve Mental Health Symptoms: a Mixed-methods Feasibility Study Protocol.
Status: COMPLETED
Conditions: Mental Health Issue
Interventions: BEHAVIORAL: Articulation/HVT|BEHAVIORAL: Soft-tissue massage|BEHAVIORAL: Craniosacral techniques|BEHAVIORAL: Combination of the three interventions: HVT, soft-tissue and craniosacral techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Low-dose Radiation Therapy in Patients With Knee Osteoarthritis (LoRD-KNeA Trial)
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: RADIATION: low-dose radiation therapy|RADIATION: sham radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Diflunisal on Familial Amyloidosis
Status: COMPLETED
Conditions: Familial Amyloid Polyneuropathy|Familial Amyloidosis
Interventions: DRUG: diflunisal|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Duloxetine and Placebo in Assessing Energy and Vitality in Major Depressive Disorder (MDD) Patients
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Duloxetine hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CPAP/PSV Preoxygenation in Obese Patients
Status: COMPLETED
Conditions: Obesity|Anaesthesia
Interventions: PROCEDURE: CPAP 5 cm H2O + PSV 5 cm H2O
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Occlusal Reduction on Post-operative Pain
Status: UNKNOWN
Conditions: Evaluate Occlusal Reduction on Post-operative Pain|Teeth With Symptomatic Irreversible Pulpitis|Apical Periodontitis
Interventions: PROCEDURE: occlusal surface reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is Periacetabular Osteotomy Superior to Progressive Resistance Training?
Status: ACTIVE_NOT_RECRUITING
Conditions: Hip Dysplasia
Interventions: PROCEDURE: PAO|OTHER: Usual care after PAO|OTHER: PRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maintenance Chemotherapy With or Without Local Consolidative Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Non-Small Cell Lung Carcinoma|Stage IV Non-Small Cell Lung Cancer
Interventions: RADIATION: 3-Dimensional Conformal Radiation Therapy (3D-CRT)|DRUG: Docetaxel|DRUG: Gemcitabine|RADIATION: Intensity-Modulated Radiation Therapy (IMRT)|DRUG: Pemetrexed Disodium|RADIATION: Stereotactic Body Radiation Therapy (SBRT)|DRUG: Erlotinib Hydrochloride|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Culturally Modified Family Based Therapy for Haitian Youth in South Florida
Status: COMPLETED
Conditions: Problem Behavior
Interventions: BEHAVIORAL: Haitian youth family-based intervention study: family functioning|BEHAVIORAL: Haitian youth intervention study: youth psychoeducational|BEHAVIORAL: Haitian family-based intervention study: psychoeducational|BEHAVIORAL: Diversion Programs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Scaleable Video Coaching Intervention for Opioid-using Mothers
Status: RECRUITING
Conditions: Child Behavior|Parent-Child Relations|Substance Use|Substance Abuse
Interventions: BEHAVIORAL: Filming Interactions to Nurture Development|BEHAVIORAL: The Healthy Toddler Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety Study of Adding Everolimus to Adjuvant Hormone Therapy in Women With High Risk of Relapse, ER+ and HER2- Primary Breast Cancer, Free of Disease After Receiving at Least One Year of Adjuvant Hormone Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Non-metastatic Breast Cancer|Who Remain Disease-free
Interventions: DRUG: Everolimus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of the Quark RMR Calorimeter (Cosmed) Versus Deltatrac II (GE Health Care Clinical Systems)
Status: UNKNOWN
Conditions: Healthy|Obesity
Interventions: DEVICE: Quark RMR|DEVICE: Deltatrac II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Hypertonic Saline Dextran in Pediatric Cardiac Surgery
Status: COMPLETED
Conditions: Heart Defects, Congenital|Transposition of Great Vessels|Heart Septal Defects, Ventricular|Endocardial Cushion Defects
Interventions: DRUG: 7.5% NaCl in 6% dextran 70 solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Telehealth in Lewy Body Dementia
Status: RECRUITING
Conditions: Lewy Body Dementia With Behavioral Disturbance|Lewy Body Parkinson Disease|Lewy Body Disease
Interventions: BEHAVIORAL: Tele-neurohub
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Prospective Evaluation of the Efficacy of Pascal Laser Iridotomy and Pascal Laser Peripheral Iridoplasty: A Pilot Study
Status: COMPLETED
Conditions: Glaucoma
Interventions: PROCEDURE: pattern scanning laser iridotomy and iridoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinic-level Implementation of mHealth to Improve HIV Viral Suppression for Patients With Substance Use Disorders
Status: ENROLLING_BY_INVITATION
Conditions: HIV Infections|Substance Use Disorders
Interventions: DEVICE: Connections App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Recombinant EphB4-HSA Fusion Protein and Azacitidine or Decitabine for Relapsed or Refractory Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia Patients Previously Treated With a Hypomethylating Agent
Status: TERMINATED
Conditions: Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Chronic Myelomonocytic Leukemia|Previously Treated Myelodysplastic Syndrome|Recurrent Acute Myeloid Leukemia With Myelodysplasia-Related Changes|Recurrent Adult Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|DRUG: Decitabine|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|BIOLOGICAL: Recombinant EphB4-HSA Fusion Protein
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of The Use of a Videolaryngoscope and/or Stylet on Intubation Time in Obese Patients
Status: COMPLETED
Conditions: Intubation Time
Interventions: PROCEDURE: Endotracheal Tube Alone|PROCEDURE: Endotracheal Tube+ Stylet|PROCEDURE: Endotracheal Tube + Video-laryngoscope|PROCEDURE: Endotracheal tube + stylet with Video-laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surfactant Administration by Insure or Thin Catheter
Status: RECRUITING
Conditions: RDS of Prematurity|Surfactant Deficiency Syndrome Neonatal|Analgesia
Interventions: PROCEDURE: Thin catheter technique or standard ET-tube for surfactant administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Research on the Effect of Aspirin on the Disease Free Survival Rate of Esophageal Carcinoma
Status: UNKNOWN
Conditions: Aspirin as an Adjuvant Therapy, to Observe Its Effect on the Disease Free Survival Rate of Patients With Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Acetylsalicylic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Stellate Ganglion Block in Post-traumatic Stress Disorder
Status: RECRUITING
Conditions: Post Traumatic Stress Disorder
Interventions: DRUG: Bupivacaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel-bevacizumab in Advanced Lung Cancer
Status: COMPLETED
Conditions: Non-squamous Non-small Cell Lung Cancer
Interventions: DRUG: Docetaxel|DRUG: Paclitaxel|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Acupressure on the "Yin-Tang" and "Shen-Men" Points on Pre and Postoperative Anxiety in Elective Caesarean Section: a Prospective, Single-blind, Randomised, Controlled Trial
Status: COMPLETED
Conditions: Cesarean Section|Pregnancy|Preoperative Anxiety
Interventions: DEVICE: ACUPRESSURE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Quality of Life Using Patient Reported Outcomes Measures Post-operative Via Text Messaging
Status: COMPLETED
Conditions: Gynecologic Cancer
Interventions: BEHAVIORAL: Standard Post-Operative Counseling + FACT-G|BEHAVIORAL: PROM symptom tracker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Elafibranor Pharmacokinetic Parameters in Hepatic Impaired Patients
Status: COMPLETED
Conditions: Hepatic Impairment|Liver Disease|Pharmacokinetics
Interventions: DRUG: Elafibranor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cytokines and Genes in Therapeutic Response in Crohn's Disease
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases
Interventions: DIAGNOSTIC_TEST: Baseline blood sample|DIAGNOSTIC_TEST: Baseline intestinal biopsies|OTHER: Crohn's disease activity index (CDAI)|DIAGNOSTIC_TEST: Post treatment blood sample|DIAGNOSTIC_TEST: Post treatment intestinal biopsies|DIAGNOSTIC_TEST: Baseline stool sample|DIAGNOSTIC_TEST: Post treatment stool sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Thermotherapy + a Short Course of Miltefosine for the Treatment of Uncomplicated Cutaneous Leishmaniasis in the New World¨
Status: COMPLETED
Conditions: Cutaneous Leishmaniasis
Interventions: DRUG: Miltefosine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Viral Inhibition in Children for Treatment of RSV
Status: COMPLETED
Conditions: RESPIRATORY SYNCYTIAL VIRUS INFECTIONS
Interventions: DRUG: AK0529|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TD-1211 Single-Dose Study in Elderly and Young Healthy Subjects
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: TD-1211 Dose 1|DRUG: TD-1211 Dose 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Natural Microbiota Restoration After C-section Birth
Status: COMPLETED
Conditions: Insufficient Intestinal Microbiota Diversity After C-section Birth
Interventions: OTHER: perineal impregnated swab|OTHER: clean swab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Immuno-ablation With Chemoimmunoradiation and Autologous Stem Cell Transplant for Churg-Strauss Syndrome
Status: TERMINATED
Conditions: Churg-Strauss Syndrome
Interventions: BIOLOGICAL: HPC cell infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Bioavailability of a Fixed Dose Combination Product of Dutasteride (0.5mg) and Tamsulosin Hydrochloride (0.2mg) Relative to Co-administration of the Individual Components in Healthy Male Subjects of North East Asian and Non-Asian Ancestry.
Status: COMPLETED
Conditions: Prostatic Hyperplasia
Interventions: DRUG: Dutasteride (0.5mg); Tamsulosin hydrochloride (0.2mg); fixed dose combination product of duatsteride (0.5mg) and tamsulosin hydrochloride (0.2mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gentulizumab in Relapsed/Refractory Acute Myelogenous Leukemia or Myelodysplastic Syndrome
Status: UNKNOWN
Conditions: Acute Myelogenous Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: Gentulizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Jiu-wei-zhen-xiao Granule for Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Jiu-wei-zhen-xiao Granule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Pharmacokinetics (PK) and Safety of Inaxaplin in Participants With Renal Impairment
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: IXP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of a Melanoma Vaccine in Stage IIb, IIc, and III Melanoma Patients
Status: TERMINATED
Conditions: Melanoma
Interventions: BIOLOGICAL: POL-103A|BIOLOGICAL: POL-103A without API
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Bowel CLEAnsing: A National Initiative
Status: COMPLETED
Conditions: Subjets Requiring a Colonoscopy
Interventions: DRUG: High volume PEG split-dose|DRUG: Low volume PEG split-dose|DRUG: High volume PEG non split, day before|DRUG: Low volume PEG non split, same day|OTHER: Clear liquid diet|OTHER: Low residue diet|OTHER: Early colonoscopy (stratified)|OTHER: Later colonoscopy (stratified)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The neoClose Abdominal Closure vs Carter-Thomason Trial
Status: COMPLETED
Conditions: Surgical Port Site Hernia
Interventions: DEVICE: Neo Close Abdominal Closure|DEVICE: Carter Thomason Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cost-effectiveness Analysis and Conditional Response to the Effect of Positional Devices in Obstructive Sleep Apnea
Status: NOT_YET_RECRUITING
Conditions: Obstructive Sleep Apnea of Adult
Interventions: DEVICE: Positional device (PD)|DEVICE: Continuos Positive Airway Pressure (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety/Efficacy Study of Immunoconjugate With Docetaxel in Non-small Cell Lung Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: SGN-15|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Meditation Therapy in Improving Anxiety and Depression in Cancer Patients With Psychosocial Distress
Status: ACTIVE_NOT_RECRUITING
Conditions: Anxiety|Depression|Malignant Neoplasm
Interventions: OTHER: Interview|PROCEDURE: Meditation Therapy|PROCEDURE: Quality-of-Life Assessment|PROCEDURE: Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE