pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety, Tolerability,and Adherence to Co-formulated Tenofovir-emtricitabine-rilpivirine Used as HIV Nonoccupational Post-exposure Prophylaxis in Men Who Have Sex With Men.
Status: COMPLETED
Conditions: HIV Nonoccupational Post-exposure Prophylaxis in Men Who Have Sex With Men
Interventions: DRUG: Eviplera = emtricitabine 200mg, rilpivirine 25mg, tenofovir 245mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: rTMS in Alleviating Pain and Co-Morbid Symptoms in Gulf War Veterans Illness (GWVI)
Status: RECRUITING
Conditions: Gulf War Illness|Depression
Interventions: DEVICE: Transcranial Magnetic Stimulation|DEVICE: Sham Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CESAR Study in Prostate Cancer With Temsirolimus Added to Standard Docetaxel Therapy (CEPTAS)
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: Docetaxel|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanisms for Activation of Beige Adipose Tissue in Humans
Status: RECRUITING
Conditions: PreDiabetes
Interventions: DRUG: Placebo|DRUG: Mirabegron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Oral Dydrogesterone (OD) Versus Micronized Vaginal Progesterone (MVP) for Luteal Phase Support (LPS) in IVF/ICSI
Status: COMPLETED
Conditions: Infertility, Female|Infertility|Genital Diseases, Male|Genital Diseases, Female|Progesterone|Dydrogesterone|Hormones|Hormones, Hormone Substitutes, and Hormone Antagonists|Physiological Effects of Drugs|Progestins
Interventions: DRUG: Dydrogesterone Oral Tablet|DRUG: Micronized progesterone|DRUG: Placebo Dydrogesterone oral tablet|DRUG: Placebo Micronized progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Effects of Mint Essential Oil
Status: COMPLETED
Conditions: Cognitive Change|Affect
Interventions: DIETARY_SUPPLEMENT: Mentha piperita|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Transcutaneous Electrical Nerve Stimulation on Cognition in Multiple Sclerosis Patients
Status: UNKNOWN
Conditions: Multiple Sclerosis|Cognitive Disorders
Interventions: DEVICE: TENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multimodel Exercise and Weight Loss in Older Obese Veterans With Dysmobility
Status: COMPLETED
Conditions: Obesity|Dysmobility
Interventions: BEHAVIORAL: Multi Modal Balance Training|BEHAVIORAL: Weight Loss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of AAV-hAADC-2 in Subjects With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: GENETIC: AAV-hAADC-2|GENETIC: AAV-hAADC-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ductus Arteriosus Closure and D-Dimer and Fibrinogen Levels
Status: RECRUITING
Conditions: Ductus Arteriosus, Patent
Interventions: DIAGNOSTIC_TEST: Withdrawal of blood samples for D-Dimer|DIAGNOSTIC_TEST: Withdrawal of blood samples for Fibrinogen|DIAGNOSTIC_TEST: Echocardiographic Examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CRAFT Behavior Therapy: Treatment Entry Component
Status: COMPLETED
Conditions: Drug Addiction|Stimulant Dependence|Opiate Dependence|Alcohol Dependence|Substance Abuse
Interventions: BEHAVIORAL: Community Reinforcement and Family Training|BEHAVIORAL: Treatment Entry Training|BEHAVIORAL: 12- step Al/Nar- Anon Facilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Dielectric Sensing (ReDS) Assisted Diuresis in Acute Decompensated Heart Failure
Status: RECRUITING
Conditions: Heart Failure; With Decompensation
Interventions: DEVICE: ReDS-Guided|DEVICE: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Probiotic and Microbiological Analysis on Oral Complications Induced by Antineoplastic Therapies in Patients With HNC
Status: ENROLLING_BY_INVITATION
Conditions: Quality of Life|Oral Mucositis|Dental Plaque|Periodontal Diseases|Xerostomia|Dysbiosis
Interventions: DIETARY_SUPPLEMENT: The probiotic to be used in the intervention corresponds to PRODEFEN Plus manufactured by ITALFARMACO S.A. laboratory|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Comparison Between Desmopressin and Fesoterodine for Treatment of Night Time Voiding in Women Aged 65 and Older
Status: TERMINATED
Conditions: Nocturia
Interventions: DRUG: Desmopressin|DRUG: Fesoterodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Comparisons of Two Donepezil Formulations
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Donepezil, ODT 10 mg|DRUG: Donepezil, 10 mg tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: BNO 1030 Extract (Imupret) in the Treatment of Mild Forms of COVID-19
Status: COMPLETED
Conditions: Covid19|Nasopharyngitis|Anosmia|Fever|Myalgia|Cough|Nasal Congestion
Interventions: DRUG: BNO 1030|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy, Cetuximab, and Injections of TNFerade™ Biologic for Elderly or Frail Patients With Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer|Head and Neck Neoplasms
Interventions: DRUG: TNFerade biologic
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Adalimumab in Subjects With Moderately to Severely Acute Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: BIOLOGICAL: adalimumab|BIOLOGICAL: adalimumab|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rituximab, Cyclophosphamide, and Corticosteroids in Primary Membranous Nephropathy
Status: RECRUITING
Conditions: Membranous Nephropathy - PLA2R Induced
Interventions: DRUG: Rituximab, Cyclophosphamide, and Corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of NY-ESO-1b Peptide Plus CpG 7909 and Montanide® ISA-51 in Patients With Cancer.
Status: COMPLETED
Conditions: Cancer|Neoplasm
Interventions: BIOLOGICAL: NY-ESO-1b peptide plus CpG 7909 and Montanide® ISA-51
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Therapy With Myo-inositol and Alpha-Lipoic Acid in PCOS Women
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Menstrual Pattern|Hyperandrogenism|Metabolic Features
Interventions: DRUG: myo-inositol,alpha-lipoic acid and folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Drug Casopitant for the Prevention of Nausea Caused By Cisplatin-Based Highly Emetogenic Chemotherapy
Status: COMPLETED
Conditions: Nausea and Vomiting, Chemotherapy-Induced
Interventions: DRUG: Oral Casopitant (GW679769)|DRUG: IV Casopitant (GW679769)|DRUG: IV ondansetron hydrochloride|DRUG: Oral dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: PREVENTION
Clinical trial: Influence of Aging on Perioperative Methadone Dosing
Status: COMPLETED
Conditions: Pain, Postoperative|Opioid Use|Methadone Overdose of Undetermined Intent
Interventions: DRUG: Methadone Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Prospective Comparison of 18F-FDG and 18F-FET PET for Response Evaluation in Patients With Primary Central Nervous System Lymphoma
Status: UNKNOWN
Conditions: Patients With Suspected or Diagnosed Central Nervous System Lymphoma
Interventions: DRUG: [18F]FET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sugammadex and Neostigmine in Pediatric Patients
Status: COMPLETED
Conditions: Postoperative Vomiting|Postoperative Nausea|Postoperative Delirium
Interventions: DRUG: Group N; neostigmine+atropine|DRUG: GROUP S; decurarized with sugammadex.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of Long-term Effects (Complications) of COVID-19 in the Southern Part of Bangladesh - a Retrospective Observational Study.
Status: UNKNOWN
Conditions: To Assess Long-term Effects of COVID-19 in Patients Who Were Affected With COVID -19
Interventions: DIAGNOSTIC_TEST: RT-PCR
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Effectiveness and Safety of Long-acting Injectable Risperidone Versus Placebo in the Treatment of Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders
Interventions: DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Haemochromatosis:Phlebotomy Versus Erythrocytapheresis Therapy
Status: COMPLETED
Conditions: Hemochromatosis
Interventions: PROCEDURE: Phlebotomy|PROCEDURE: Erythrocytapheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mesothelin-Targeted Immunotoxin LMB-100 in People With Malignant Mesothelioma
Status: COMPLETED
Conditions: Mesothelioma
Interventions: DRUG: LMB-100|DRUG: nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concurrent Chemoradiotherapy With Nedaplatin Versus Cisplatin in Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Nedaplatin|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Pharmacokinetics of Digoxin When Coadministered With PEX168 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PEX168|DRUG: Digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Treatment Of Dupuytren's Contracture With Collagenase Clostridium Histolyticum Injection (Xiapex)
Status: COMPLETED
Conditions: Dupuytren's Contracture
Interventions: DRUG: Xiapex
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantification of Liver Iron Overload and Steatosis Using Magnetic Resonance Imaging
Status: COMPLETED
Conditions: Iron Overload|Metabolic Syndrome X|Hepatitis B|Hepatitis C|Alcohol Abuse
Interventions: DEVICE: Magnetic resonance imaging multiecho gradient-echo sequence
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Optimum-pressure for Reducing Postoperative Shoulder-tip Pain in Laparoscopic Cholecystectomy
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: PROCEDURE: Intraabdominal pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effectiveness of an HIV Vaccine (ALVAC vCP205) to Boost Immune Functions in HIV-Negative Volunteers Who Have Already Received an HIV Vaccine
Status: COMPLETED
Conditions: HIV Infections|HIV Seronegativity
Interventions: BIOLOGICAL: ALVAC-HIV MN120TMG (vCP205)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Plasma Exchange for Renal Vasculitis
Status: TERMINATED
Conditions: Wegener's Granulomatosis|Microscopic Polyangiitis
Interventions: PROCEDURE: Plasma exchange|DRUG: Intravenous methyl prednisolone|DRUG: Methyl prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Holographic Augmented Reality Versus Screen Visualisation of 3D Rendering Models for the Pre-operative Evaluation and Planning of Liver Resections
Status: COMPLETED
Conditions: Hepatobiliary Neoplasm
Interventions: OTHER: Holograms|OTHER: PDF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Outpatient Versus Inpatient Surgery for Ankle Fractures
Status: RECRUITING
Conditions: Ankle Fractures|Orthopedic Procedures|Surgical Procedures|Inpatient
Interventions: PROCEDURE: Ambulatory care|PROCEDURE: Inpatient care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Fats on Satiety and Energy Needs
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: SFA|OTHER: MUFA|OTHER: PUFA-LA|OTHER: ALA|OTHER: LCn3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Integration of Neurofunctional Phenotyping Into Investigation of CBT4CBT for AUD
Status: RECRUITING
Conditions: Alcohol Abuse|Alcohol Use Disorder
Interventions: BEHAVIORAL: Stand-alone web-based cognitive behavioral therapy (CBT4CBT) for alcohol use disorder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: St. John's Wort in Relieving Hot Flashes in Postmenopausal Women With Non-Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer|Hot Flashes
Interventions: DRUG: St. John's Wort
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma, B-Cell|Small Lymphocytic Lymphoma|Chronic Lymphocytic Leukemia|Waldenstrom Macroglobulinemia|Mantle Cell Lymphoma|Diffuse Large B Cell Lymphoma|Richter's Transformation|Follicular Lymphoma|Marginal Zone Lymphoma
Interventions: DRUG: Nemtabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Calcium Supplementation on Insulin Resistance and 24h Blood Pressure
Status: COMPLETED
Conditions: Hypertension|Diabetes|Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: tablets each containing of 1000mg elemental calcium (Mega-Calcium Sandoz)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Discontinuation Study of Imatinib in Adult CP CML Patients Who Have a Complete Molecular Response to Imatinib
Status: UNKNOWN
Conditions: Chronic Myeloid Leukemia|Imatinib|Complete Molecular Response
Interventions: BEHAVIORAL: Imatinib treatment discontinuing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intestinal Permeability and Intestinal Microbiota in Irritable Bowel Syndrome
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome With Diarrhea
Interventions: DRUG: prescribing anapproved drug, examination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety of LBH589 Alone and in Combination With Intravenous Docetaxel and Prednisone
Status: TERMINATED
Conditions: Hormone Refractory Prostate Cancer Disease
Interventions: DRUG: LBH589
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of APB-R3
Status: COMPLETED
Conditions: Still's Disease, Adult-Onset
Interventions: DRUG: APB-R3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Alveolar Recruitment Maneuver in Laparoscopic Surgery
Status: UNKNOWN
Conditions: Postoperative Pulmonary Complication
Interventions: PROCEDURE: Alveolar recruitment maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Olfactory Outcomes of Dupilumab Treatment for Nasal Polyposis
Status: RECRUITING
Conditions: Chronic Rhinosinusitis With Nasal Polyps|Olfactory Disorder
Interventions: DRUG: Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Dose Escalation Study of VELCADE Plus Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer or Other Solid Tumors
Status: TERMINATED
Conditions: Advanced Non-Small Cell Lung Cancer|Other Solid Tumors
Interventions: DRUG: VELCADE TM (bortezomib) for Injection, or PS-341
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of RAD001 for Treatment of NF2-related Vestibular Schwannoma
Status: TERMINATED
Conditions: Neurofibromatosis Type 2|Neuroma, Acoustic
Interventions: DRUG: RAD001, everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Performance of a Robotic Flexible Ureteroscopy (ILY) in Laser Treatment of Nephrolithiasis
Status: WITHDRAWN
Conditions: Lithiasis, Urinary
Interventions: DEVICE: ILY robotic flexible ureteroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Stereotactic Body Radiation Therapy for Patients After Radical Resection of Pancreatic Cancer With Advanced Stages (T3 or N1)
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: DRUG: Gemcitabine|RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-Dose Rate Brachytherapy and Stereotactic Body Radiation Therapy in Treating Patients With Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer|Adenocarcinoma of the Prostate|Recurrent Prostate Cancer|Stage IIA Prostate Cancer|Stage IIB Prostate Cancer
Interventions: RADIATION: Brachytherapy|RADIATION: Stereotactic Body Radiation Therapy|PROCEDURE: Quality-of-life assessment|OTHER: Questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calorie Restriction, Protein Supplementation and Metabolic Health
Status: COMPLETED
Conditions: Obesity|Menopause|Osteoporosis|Sarcopenia
Interventions: BEHAVIORAL: Weight loss with normal protein intake|BEHAVIORAL: Weight loss with protein supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of the Optimal Scheme of Administration of Pazopanib in Thyroid Carcinoma
Status: COMPLETED
Conditions: Thyroid Carcinoma
Interventions: DRUG: Continuous pazopanib (Arm A)|DRUG: Intermittent pazopanib (Arm B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Study of VAH631 in Patients With Essential Hypertension (Extension From B1303 Study)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Valsartan + Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acceptance and Commitment Therapy and Exercise for Older Adults With Chronic Pain
Status: UNKNOWN
Conditions: Chronic Pain|Older Adults|Acceptance and Commitment Therapy|Exercise|Psychosocial Intervention|Art
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy (ACT)|OTHER: Art|OTHER: Exercise|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Different Doses of Epinephrine on Biomarkers of Nervous System Ischemia-reperfusion Injury in Patients With Stanford Type A Dissection
Status: COMPLETED
Conditions: Adrenaline; Aortic Dissection; Drug Dose; Nervous System; Ischemia Reperfusion Injury
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preoperative CRT With Capecitabine ± Temozolomide in Patients With LARC
Status: COMPLETED
Conditions: Advanced Rectal Cancer
Interventions: DRUG: Capecitabine plus temozolomide VS Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determinants of Cognitive Impairment Among Geriatrics
Status: UNKNOWN
Conditions: Cognitive Impairment|Dementia|Hearing Impairment|Vision Impairment and Blindness|Diabetes|Dyslipidemias|Obesity|Central Obesity|Mobility Limitation|Osteoarthritis|Hypertension|Depression
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chesterfield Micro-implant Study Involving Three Types of Anchorage Methods in Orthodontics
Status: COMPLETED
Conditions: Malocclusion|Class II Buccal Segment Relationship
Interventions: DEVICE: Extraoral anchorage|DEVICE: Miniscrews|DEVICE: Nance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biliary Tissue Sampling Using a Cytology Brush or the GIUM Catheter
Status: UNKNOWN
Conditions: Pancreatic Neoplasms|Cholangiocarcinoma|Pancreatitis
Interventions: DEVICE: Tissue sampling ("G.I.U.M." catheter)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Drugs on Responses to Brain and Emotional Processes
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Healthy
Interventions: DRUG: MDMA|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Influence of Fluvoxamine on the Pharmacokinetics of BI 409306
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Fluvoxamine|DRUG: BI 409306 - Powder for oral solution (PfOS)|DRUG: BI 409306 - film coated tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of OMS906 in Patients With C3G and ICGN
Status: RECRUITING
Conditions: C3 Glomerulopathy|Idiopathic Immune Complex-Mediated Glomerulonephritis
Interventions: DRUG: OMS906 study drug
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Cilnidipine on Metabolic Syndrome Improvement
Status: COMPLETED
Conditions: Hypertension|Metabolic Syndrome X
Interventions: DRUG: Cilnidipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The ESTxENDS Trial- Substudy on the Metabolic Effects of Using Electronic Nicotine Delivery Systems (ENDS/Vaporizer/E-cig)
Status: COMPLETED
Conditions: Smoking Cessation|Cardiovascular Diseases
Interventions: OTHER: ENDS (vaporizer/e-cig) and smoking cessation counseling|OTHER: Smoking cessation counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Studies of the Ocular Complications of AIDS (SOCA)--Foscarnet-Ganciclovir CMV Retinitis Trial (FGCRT)
Status: COMPLETED
Conditions: HIV Infections|Cytomegalovirus Retinitis
Interventions: DRUG: Foscarnet|DRUG: Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characterizing the Impact of Presbyphonia on Social Interaction
Status: NOT_YET_RECRUITING
Conditions: Presbyphonia
Interventions: OTHER: PhoRTE Program|OTHER: University of California Los Angeles (UCLA) Loneliness Scale|OTHER: Social Disconnectedness Scale|OTHER: Patient Health Questionnaire 9|OTHER: Aging Voice Index|OTHER: The Edmonton Frail Scale|OTHER: Vocal Effort Scale|OTHER: Montreal Cognitive Assessment|OTHER: Voice Handicap Index-10|OTHER: Voice Problem Impact Scales|OTHER: Cough Severity Index|PROCEDURE: Laryngoscopy|OTHER: Acoustic, perceptual, and aerodynamic assessments
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Control and Subconjunctival Hemorrhage Size After Intravitreal Injection
Status: COMPLETED
Conditions: Intravitreal Injection|Pain|Subconjunctival Hemorrhage
Interventions: PROCEDURE: Cooled eye drops and povidone-iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Protein Source on Appetite Control, Satiety, and Subsequent Food Intake: A Clinical Screening Study
Status: COMPLETED
Conditions: Appetitive Behavior
Interventions: DIETARY_SUPPLEMENT: Pea Protein-20g|DIETARY_SUPPLEMENT: Pea Protein-30g|DIETARY_SUPPLEMENT: Pea Protein-40g|DIETARY_SUPPLEMENT: Whey Protein-20g|DIETARY_SUPPLEMENT: Carbohydrate Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Celecoxib and Radiation Therapy in Treating Patients With Stage II or Stage III Soft Tissue Sarcoma of the Arm, Hand, Leg, or Foot That Has Been Removed by Surgery
Status: COMPLETED
Conditions: Childhood Malignant Fibrous Histiocytoma of Bone|Sarcoma
Interventions: DRUG: celecoxib|PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Therapy With Iruplinalkib for Potentially Resectable ALK Positive NSCLC: A Single Arm, Exploratory Trial
Status: NOT_YET_RECRUITING
Conditions: Potentially Resectable ALK Positive Non-Small Cell Lung Cancer
Interventions: DRUG: Iruplinalkib|PROCEDURE: surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Vaccination Detoxification in LDL-C
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19 Stress Syndrome|COVID-19 Vaccine Adverse Reaction|COVID-19-Associated Thromboembolism|COVID-19 Post-Intensive Care Syndrome|COVID-19-Associated Stroke|COVID-19 Respiratory Infection
Interventions: COMBINATION_PRODUCT: Atorvastatin Calcium Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Advanced Malignant Neoplasm|Acute Myeloid Leukemia|Mixed Lineage Leukemia|Mixed Lineage Acute Leukemia|Acute Leukemia of Ambiguous Lineage|Mixed Phenotype Acute Leukemia
Interventions: DRUG: Ziftomenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation of a New Motor Skill Learning Therapeutic Device in Children With Cerebral Palsy Rehabilitation
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: BEHAVIORAL: Hand Arm Bimanual Intensive Therapy Including Lower Extremities|BEHAVIORAL: Conventional physical and occupational therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gut Bacteria and Brain of the Baby
Status: RECRUITING
Conditions: Premature
Interventions: OTHER: Data collection of environmental factors|OTHER: Collection of maternal feces|OTHER: Collection of infant feces|OTHER: food questionnaire|OTHER: a food questionnaire on the infant alimentation and food behavior during the period of 2 and 10 months of age|OTHER: a food questionnaire on the infant alimentation and food behavior during the period of 12 and 24 months of age|OTHER: Sample of milk|OTHER: The 'Ages and Stages Questionnaire' ASQ
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Melatonin Use After Primary Total Joint Arthroplasty
Status: COMPLETED
Conditions: Osteo Arthritis Knee
Interventions: DRUG: Melatonin 5 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Band vs. Dual Band Pulsed Light Technology for the Treatment of Photodamage - A Split Face Comparison Study
Status: COMPLETED
Conditions: Photodamage
Interventions: DEVICE: Single Band vs. Dual Band Pulsed Light Technology for the Treatment of Photodamage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutrient Timing in Connection to Evening Exercise
Status: COMPLETED
Conditions: Carbohydrate Metabolism|Lipid Metabolism|Blood Glucose|Oral Glucose Tolerance Test
Interventions: OTHER: Carbohydrate timing - carbohydrate intake before or after exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Visual and Auditory Neuromodulation of Pain Perception
Status: COMPLETED
Conditions: Pain, Acute
Interventions: BEHAVIORAL: Interoceptive breathing awareness through use of audio and visual virtual technology aid|BEHAVIORAL: Interoceptive breathing awareness without use of audio or visual virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of the Safety and Effectiveness of Oral Levofloxacin Compared With Oral Ciprofloxacin in the Treatment of Adults With Mild to Moderate Infections of the Skin and the Supportive Layers Beneath the Skin
Status: COMPLETED
Conditions: Skin Diseases, Infectious|Cellulitis
Interventions: DRUG: levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interferon Alfa in Treating Patients With Stage IV Solid Tumors, Lymphoma, or Myeloma
Status: COMPLETED
Conditions: Breast Cancer|Kidney Cancer|Lymphoma|Melanoma|Multiple Myeloma|Sarcoma|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: recombinant interferon alpha-1b|DRUG: IFN
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Triaging of Newly Diagnosed Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: Paclitaxel|DRUG: Fluorouracil|DRUG: Doxorubicin|DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peri-operative Zimberelimab (Anti-PD-1) vs Zimberelimab in Combination With Domvanalimab (Anti-TIGIT) in Resectable Mismatch Repair Deficient/Micro-satellite Unstable Gastric and Gastro-oesophageal Junctional Adenocarcinoma (ZODIAC)
Status: NOT_YET_RECRUITING
Conditions: Metastatic Esophageal Cancer|Metastatic Gastric Cancer
Interventions: DRUG: Single agent zimberelimab|DRUG: Combination zimberelimab + domvanalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Medication Adherence Among People With Schizophrenia Through the Use of 2-way Pagers
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DEVICE: 2-way pager|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Telehealth Intervention Involving HEARTS Technical Package and Activity Monitor to Promote Physical Activity Post-stroke
Status: RECRUITING
Conditions: Stroke
Interventions: BEHAVIORAL: Telehealth intervention: HEARTS technical package + activity monitor (Smartwatch Mi Band 7®)|BEHAVIORAL: Telehealth intervention: HEARTS technical package
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Semaglutide on Disordered Eating Behaviour in Type 2 Diabetic Patients
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes|Overweight|Disordered Eating Behaviors
Interventions: DRUG: Semaglutide|DRUG: standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Follow-up Study to Evaluate the Long-term Efficacy of the HPV Vaccine (580299) in Healthy Young Adult Women in Brazil
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: PROCEDURE: Blood sampling|PROCEDURE: Collection of cervical specimen|BIOLOGICAL: Cervarix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effectiveness of Non-Pyrethroid Insecticide-Treated Durable Wall Liners as a Method for Malaria Control in Endemic Rural Tanzania
Status: TERMINATED
Conditions: Malaria
Interventions: DRUG: abamectin and fenpyroximate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Investigation of Efficacy of Secukinumab in Patients With Moderate to Serve Atopic Dermatitis
Status: COMPLETED
Conditions: Dermatitis, Atopic|Eczema, Atopic|Neurodermatitis, Atopic
Interventions: DRUG: Secukinumab 300 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of a Short Illumination Duration (35 Minutes) When Performing PDT of AK Using the Dermaris ®
Status: COMPLETED
Conditions: Actinic Keratoses
Interventions: COMBINATION_PRODUCT: Metvix + Dermaris
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gargling and Nasal Rinses to Reduce Oro- and Nasopharyngeal Viral Load in Patients With COVID-19
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: Saline oral/nasal rinse|DRUG: 0.5% Povidone/Iodine oral/nasal rinse|DRUG: 0.12% Chlorhexidine oral/nasal rinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of Telemedicine in Primary Care
Status: COMPLETED
Conditions: Asthma|Chronic Obstructive Pulmonary Disease (COPD|Congestive Heart Failure|Diabetes|Hypertension
Interventions: OTHER: Exposure to telemedicine, after the onset of the pandemic
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: GISSI-HF- Effects of n-3 PUFA and Rosuvastatin on Mortality-Morbidity of Patients With Symptomatic CHF
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: n-3 PUFA|DRUG: Rosuvastatin|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Indirect Comparison of Tobramycin Solution for Inhalation Versus Aztreonam Lysine for Inhalation in the Treatment of Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Tobramycin solution for inhalation|DRUG: Aztreonam lysine for inhalation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of SensaScope Intuboscope and McGrath Series 5 for Endotracheal Intubation
Status: COMPLETED
Conditions: Airway Morbidity
Interventions: DEVICE: Time for tracheal intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Metastatic Melanoma With Tumor Infiltrating Lymphocytes and IL-2 Following Lympho-depleting Chemotherapy
Status: UNKNOWN
Conditions: Metastatic Melanoma
Interventions: BIOLOGICAL: tumor infiltrating lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Short-term Immunosuppressive Therapy and Anti-allergenic Therapy in Severe Acute Exacerbation of Chronic Hepatitis B
Status: UNKNOWN
Conditions: Severe Acute Exacerbation of Chronic Hepatitis B
Interventions: DRUG: methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Investigating Fitness Interventions in the Elderly (INFINITE)
Status: COMPLETED
Conditions: Obesity|Older Adults|Sedentary
Interventions: BEHAVIORAL: Exercise Only|BEHAVIORAL: Exercise + Diet|BEHAVIORAL: Exercise + Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of an Oral Solution of Copegus (Ribavirin) Compared to Copegus Tablets
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: ribavirin [Copegus]|DRUG: ribavirin [Copegus]|DRUG: ribavirin [Copegus]|DRUG: ribavirin [Copegus]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Pilot Study of Vitamin K2 (MK-7) and Vitamin D3 Supplementation and the Effects on PASC Symptomatology and Inflammatory Biomarkers
Status: ACTIVE_NOT_RECRUITING
Conditions: Post-acute COVID-19 Syndrome
Interventions: DIETARY_SUPPLEMENT: Vitamin K2 (MK-7)|DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exclusion Diet vs corticosteroIds in patientS With activE Crohn's Disease
Status: NOT_YET_RECRUITING
Conditions: Crohn Disease
Interventions: DIETARY_SUPPLEMENT: Crohn's disease exclusion diet (CDED)|DRUG: Oral prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Of PGN-EDO51 In Participants With Duchenne Muscular Dystrophy Amenable To Exon 51-Skipping Treatment
Status: RECRUITING
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: PGN-EDO51
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adductor Canal Block In Anterior Cruciate Ligament (ACL) Repair
Status: COMPLETED
Conditions: Neuromuscular Block
Interventions: PROCEDURE: Adductor Canal Block|PROCEDURE: Femoral Nerve Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: E7 TCR Cell Induction Immunotherapy for Stage II and Stage III HPV-Associated Oropharyngeal Cancer
Status: TERMINATED
Conditions: Papillomavirus Infections|Oropharyngeal Neoplasms
Interventions: BIOLOGICAL: E7 T-Cell Receptor (TCR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Akathisia Incidence of Slow Infusion Metoclopramide
Status: COMPLETED
Conditions: Akathisia|Nausea
Interventions: DRUG: metoclopramide 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: AMG 531 Treatment of Thrombocytopenic Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Prior to Splenectomy
Status: COMPLETED
Conditions: Thrombocytopenia|Idiopathic Thrombocytopenic Purpura
Interventions: BIOLOGICAL: AMG 531|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Psychotherapy for Depressed Parkinson's Disease Patients
Status: COMPLETED
Conditions: Depression|Parkinson's Disease
Interventions: BEHAVIORAL: Interpersonal Psychotherapy|BEHAVIORAL: Supportive Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunization With AFP + GM CSF Plasmid Prime and AFP Adenoviral Vector Boost in Patients With Hepatocellular Carcinoma
Status: TERMINATED
Conditions: Hepatocellular Carcinoma|Hepatoma|Liver Cancer, Adult|Liver Cell Carcinoma|Liver Cell Carcinoma, Adult|Cancer of Liver|Cancer of the Liver|Cancer, Hepatocellular|Hepatic Cancer|Hepatic Neoplasms|Hepatocellular Cancer|Liver Cancer|Neoplasms, Hepatic|Neoplasms, Liver
Interventions: DRUG: AFP + GM-CSF Plasmid Prime and AFP Adenoviral Vector Boost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BP Variability on the Outcomes of Hemodialysis Vascular Access
Status: UNKNOWN
Conditions: Hemodialysis Access Failure|Blood Pressure|Dialysis Access Malfunction
Interventions: DIAGNOSTIC_TEST: Measure: BP measurements, inter-dialysis BP variability, intra-dialysis hypotension
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Radiotherapy or Radiosurgery Compared With Observation Alone in Treating Patients With Newly Diagnosed, Benign Meningioma That Has Been Partially Removed by Surgery
Status: TERMINATED
Conditions: Brain and Central Nervous System Tumors
Interventions: PROCEDURE: adjuvant therapy|RADIATION: radiation therapy|RADIATION: stereotactic radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Glycocalyx Levels in Patients Undergoing Pancreatectomy
Status: UNKNOWN
Conditions: Endothelial Degeneration|Pancreatic Cancer|Pancreatectomy|Postoperative Pancreatic Fistula
Interventions: OTHER: human albumin 5%|OTHER: gelofusine.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Imvotamab Monotherapy and in Combination in Subjects With Relapsed/Refractory Non-Hodgkin Lymphoma
Status: TERMINATED
Conditions: Non-Hodgkin Lymphoma|Follicular Lymphoma|DLBCL|Mantle Cell Lymphoma|Marginal Zone Lymphoma
Interventions: DRUG: imvotamab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Facilitating Learning Health Care (LHC) and Neonatal Research: Effects of a Brief Introductory Discussion Between a Neonatologist and the Parents of Eligible Infants
Status: COMPLETED
Conditions: Understanding of Consent in Clinical Research|Implementation of Consent in Clinical Research
Interventions: OTHER: Consultation meeting|OTHER: Pamphlet|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: UTAA06 Injection for Treatment of Advanced Malignant Solid Tumors
Status: RECRUITING
Conditions: Conditions or Focus of Study: B7-H3 Positive Relapsed/Advanced Malignant Solid Tumor
Interventions: BIOLOGICAL: UTAA06 injection for treatment of advanced malignant solid tumors
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT