pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Dideoxycytidine ( Ro 24-2027 ) A Randomized, Open-Label, Comparative Study of Dideoxycytidine ( ddC ) Versus Zidovudine ( AZT ) in Patients With AIDS or Advanced ARC Who Have Received Long-Term AZT Therapy.
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zidovudine|DRUG: Zalcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Tolerability of Single Doses of REGN1500
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DRUG: REGN1500|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of VYN201 Gel in Subjects With Non-segmental Vitiligo.
Status: RECRUITING
Conditions: Non-segmental Vitiligo
Interventions: DRUG: VYN201 Gel|DRUG: Vehicle Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of naïve Patients With Age-related Macular Degeneration Neovascular Type and Treated With Ranibizumab (Lucentis®) in Treat-and-extend at the CHU Brugmann.
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: OTHER: Data extraction from medical files
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pain Management During Screening for Retinopathy of Prematurity
Status: COMPLETED
Conditions: Retinopathy of Prematurity|Pain Management
Interventions: DRUG: Ibuprofen (Sanofi, Istanbul, Turkey)|DRUG: Paracetamol (GlaxoSmithKline, Istanbul, Turkey)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Correlation of Cross Sectional Imaging and Small Intestinal Contrast Ultrasonography in Known Crohn's Disease
Status: RECRUITING
Conditions: Crohn Disease|Ultrasound Therapy; Complications|Computed Tomography|Magnetic Resonance Imaging
Interventions: DIAGNOSTIC_TEST: Small intestinal contrast enhanced ultrasound followed by Computed tomography/Magnetic resonance enterography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Personalized DC Vaccine for Postoperative Cancer
Status: RECRUITING
Conditions: Gastric Cancer|Hepatocellular Carcinoma|Non-Small-Cell Lung Cancer|Colon Rectal Cancer
Interventions: BIOLOGICAL: DC vaccine subcutaneous administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Galactose Ingestion on Postprandial Lipemia
Status: COMPLETED
Conditions: Cardiovascular Risk Factor|Lipemia
Interventions: DIETARY_SUPPLEMENT: Galactose|DIETARY_SUPPLEMENT: Glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Innovations in Treating COPD Exacerbations: Pilot Project on Action Plans Using New Technology.
Status: COMPLETED
Conditions: COPD
Interventions: BEHAVIORAL: COPD self-management using an action plan|DEVICE: Telesystem-Phone self-assessment/reporting system|OTHER: Nurse case manager support
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Axatilimab Monotherapy in Japanese Participants With Recurrent or Refractory Active Chronic Graft-Versus-Host Disease
Status: RECRUITING
Conditions: Chronic Graft-versus-host-disease
Interventions: DRUG: INCA034176
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Four-day Intensive Treatment Versus Standard Cognitive Behavioral Therapy for Adults With Obsessive-compulsive Disorder
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: BEHAVIORAL: Bergen 4-Day Treatment (B4DT)|BEHAVIORAL: Gold standard cognitive behavioral therapy (gold standard CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bepotastine Besilate-corticosteroid Nasal Spray Combination Compared to Placebo, Bepotastine Besilate Nasal Spray, and Corticosteroid Nasal Spray in the Treatment of Patients With Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Bepotastine besilate formulation|DRUG: Fluticasone propionate|DRUG: Bepotastine besilate-fluticasone propionate|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Can Advair and Flovent Reduce Systemic Inflammation Related to Chronic Obstructive Pulmonary Disease (COPD)? A Multi-Center Randomized Controlled Trial
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Advair|DRUG: Flovent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Phthalate-Allergen Immune Response Study
Status: UNKNOWN
Conditions: Allergies
Interventions: OTHER: Phthalate|OTHER: Filtered Air|OTHER: Allergen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Melphalan, Prednisone, Thalidomide and Defibrotide in Relapsed Multiple Myeloma Patients
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Prednisone|DRUG: Melphalan|DRUG: Thalidomide|DRUG: Defibrotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of an Alginate Based Beverage on Weight Loss
Status: COMPLETED
Conditions: Obesity|Type 2 Diabetes|Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: Alginate beverage|DIETARY_SUPPLEMENT: Control beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Rucaparib and Nivolumab in People With Leiomyosarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Leiomyosarcoma
Interventions: DRUG: Rucaparib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of SHR3680 in Treating Patients With Hormone Sensitive Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer|Hormone-Dependent Prostate Cancer
Interventions: DRUG: SHR3680|DRUG: Bicalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of ABX-1431 on Patients With Functional Dyspepsia
Status: TERMINATED
Conditions: Dyspepsia
Interventions: DRUG: ABX-1431|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Secukinumab Compared to Etanercept in Subjects With Moderate to Severe, Chronic Plaque-Type Psoriasis
Status: COMPLETED
Conditions: Chronic Plaque Psoriasis
Interventions: DRUG: Placebo|DRUG: secukinumab (AIN457)|DRUG: etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Neural Mobilization on Lumbosacral Radiculopathy Patients With Peripheral Sensitization
Status: COMPLETED
Conditions: Radiculopathy
Interventions: OTHER: Neural mobilization exercises -Tensioner technique|OTHER: Neural mobilization exercises -Slider technique|OTHER: Transcutaneous Electrical Nerve Stimulation (TENS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Safety, Tolerability and Pharmacokinetics of Apremilast (CC-10004) in Pediatric Subjects With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Apremilast
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LUS to Assess Lung Injury After Lung Lobectomy
Status: UNKNOWN
Conditions: Lung Neoplasm|Adult ALL|Lung Injury|Lung Inflammation|Lung Ischemia/Hypoxia|Postoperative Complications|Postoperative Respiratory Complication|Lung Cancer|Thoracic
Interventions: PROCEDURE: Thoracotomy|PROCEDURE: VATS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Resiliency in Older Adults Undergoing Bone Marrow Transplant
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukemia|Lymphoma|Blood Cancer|Myelodysplastic Syndrome|Acute Myelogenous Leukemia|Non-Hodgkins Lymphoma
Interventions: OTHER: Bone Marrow Transplant (BMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Short-term Effects of Perindopril-amlodipine Versus Perindopril-indapamide in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Hypertension
Interventions: DRUG: Perindopril and Amlodipine|DRUG: Perindopril-indapamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicentre, Randomized Phase III Study of Rituximab as Maintenance Treatment Versus Observation in Patients With Aggressive B-cell Lymphoma: NHL-13
Status: COMPLETED
Conditions: Diffuse Large B-Cell Lymphoma (DLBCL)|Follicular NHL Grade 3b
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Camrelizumab Combined With APatinib and Albumin Paclitacxel in Patients With Advanced Lung Adenocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Adenocarcinoma of the Lung
Interventions: DRUG: Camrelizumab|DRUG: Albumin Paclitacxel|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study for Safety and Tolerability of EBI-005 Topically Administered to Eyes of Healthy Adult Subjects
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: EBI-005-1|DRUG: EBI-005-1 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tracking IUD Bleeding Experiences: An Evaluation of Bleeding Profiles in New Intrauterine Device Users
Status: COMPLETED
Conditions: Intrauterine Devices, Copper|Metrorrhagia|Menstruation|Menstrual Cycle
Interventions: DEVICE: T380A Intrauterine Copper Contraceptive
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pterygopalatine Fossa Block in Aneurysmal Subarachnoid Hemorrhage
Status: COMPLETED
Conditions: Subarachnoid Hemorrhage, Aneurysmal
Interventions: PROCEDURE: Ptergyopalatine Fossa Block|DRUG: Bupivacaine 0.25% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Liraglutide in Japanese Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: liraglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exploration of Fenestration Decompression Combined With Dalafenib in the Treatment of BRAF Mutant Ameloblastoma
Status: NOT_YET_RECRUITING
Conditions: Ameloblastoma
Interventions: DRUG: Dabrafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Results of Percutaneous Left Atrial Closure at Brest University Hospital (CLAPOT)
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation|Cardioembolic Stroke|Left Atrial Appendage Thrombosis|Anticoagulant-induced Bleeding
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Optimizing Postoperative Pain Control After Laparoscopic Colorectal Surgery
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: OTHER: Bupivacaine and ketamine|OTHER: Bupivacaine and transdermal fentanyl patch|OTHER: Bupivacain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Landiolol in Postoperative Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Landiolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human CD19-CD22 Targeted T Cells Injection for Refractory/Relapsed Central Nervous System Leukemia/Lymphoma Patients
Status: RECRUITING
Conditions: Central Nervous System Lymphoma
Interventions: DRUG: Human CD19-CD22 Targeted T Cells Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ALTO-300 in MDD
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DRUG: ALTO-300|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Recombinant, Bivalent, Norovirus Vaccine Study
Status: COMPLETED
Conditions: Norovirus
Interventions: BIOLOGICAL: Norovirus GI.4 / GII.4 Bivalent VLP Vaccine (100 µg)|BIOLOGICAL: Norovirus GI.4 / GII.4 Bivalent VLP Vaccine (300 µg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Test the Safety and Efficacy of Cannabidiol as a Treatment Intervention for Opioid Relapse
Status: COMPLETED
Conditions: Opiate Addiction
Interventions: DRUG: Cannabidiol|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of TRK-950 When Used in Combination With Ramucirumab and Paclitaxel in Patients With Gastric Cancer
Status: RECRUITING
Conditions: Gastric Adenocarcinoma|Gastric Cancer|Gastroesophageal Junction Adenocarcinoma
Interventions: BIOLOGICAL: TRK-950|DRUG: Ramucirumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study on Acuris™ - Conometric Concept for Single Tooth Restoration
Status: ACTIVE_NOT_RECRUITING
Conditions: Jaw, Edentulous, Partially
Interventions: DEVICE: Conometric Abutment and Conometric Final Cap
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oropharyngeal Administration of Colostrum to Very Low Birth Weight Infants
Status: COMPLETED
Conditions: Infant, Very Low Birth Weight
Interventions: PROCEDURE: Oropharyngeal administration of colostrums|PROCEDURE: Oropharyngeal administration of Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Innovative Taping Technique for Improved Intravenous (IV) Catheter Securement
Status: COMPLETED
Conditions: Dislodged Catheter|Catheter Related Complication
Interventions: DEVICE: Novel Taping Method|DEVICE: BCH Emergency Department Taping Method|DEVICE: Chevron Taping Method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: IT Enhanced Peer Integrated Collaborative Care for US Trauma Care Systems
Status: ACTIVE_NOT_RECRUITING
Conditions: PTSD|Physical Injury
Interventions: BEHAVIORAL: Peer-Integrated Multidisciplinary Collaborative Care|BEHAVIORAL: Trauma surgery team notification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare 2 Doses of Polycap Versus Single Dose of Polycap With or Without Pottasium
Status: COMPLETED
Conditions: Ischemic Heart Disease|Ischemic Stroke|Peripheral Vascular Disease|Type 2 Diabetes Mellitus
Interventions: DRUG: Single Dose Polycap|DRUG: Double dose Polycap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Removable Cast Walker Design on Usability for Patients With Diabetic Foot Ulcers
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus|Foot Ulcer
Interventions: DEVICE: RCW design form
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repeat Dose GW685698X With Magnesium Stearate, Excipient Bridging Study, In Healthy Volunteers
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: GW685698X|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Transporters for Organic Cations and Glycemic Control in Patients With Neuropathic Pain.
Status: COMPLETED
Conditions: Neuropathic Pain|Type 2 Diabetes Mellitus|Diabetic Neuropathy, Painful
Interventions: PROCEDURE: Serial Blood Samples|PROCEDURE: Serial Urine Samples|DRUG: Gabapentin 300 mg|DRUG: Cetirizine Hydrochloride 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Liposomal Irinotecan for Advanced Refractory Gastric Cancer
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Liposomal Irinotecan Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Rivaroxaban Venous Thromboembolism (VTE) Prophylaxis in Ambulatory Cancer Participants
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Rivaroxaban|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Psilocybin rTMS for Treatment Resistant Depression
Status: NOT_YET_RECRUITING
Conditions: Treatment Resistant Depression|MDD|Major Depressive Disorder|Recurrent Depression|Depression
Interventions: DRUG: Psilocybin|DEVICE: Accelerated intermittent theta burst (aiTBS) rTMS treatment|DRUG: Low-dose psilocybin|DEVICE: Sham Accelerated intermittent theta burst (aiTBS) rTMS treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3
Status: RECRUITING
Conditions: Withdrawal Symptoms|Opioid Use Disorder|Opioid Use
Interventions: DEVICE: Transcutaneous Cervical Vagal Nerve Stimulation|DEVICE: Sham Stimulation|DRUG: [F-18]Fallypride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Explore the Role of Gut Flora in Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer|Colorectal Neoplasms|Colorectal Carcinoma|Colorectal Adenocarcinoma|Colorectal Cancer Metastatic|Colorectal Sarcoma
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Methotrexate, Cyclophosphamide, and Etoposide Phosphate Given With Osmotic Blood-Brain Barrier Disruption Plus Dexamethasone and Cytarabine in Treating Patients With Primary CNS Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: pegfilgrastim|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: dexamethasone|DRUG: etoposide phosphate|DRUG: methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label, Follow-up Study of Oral Testosterone Undecanoate in Hypogonadal Men
Status: COMPLETED
Conditions: Male Hypogonadism
Interventions: DRUG: Oral testosterone undecanoate|DRUG: Transdermal testosterone gel (AndroGel)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Right Ventricular (RV) Size and Function Using the Upper Valley RV Algorithm and Novel Imaging Modalities
Status: TERMINATED
Conditions: Pulmonary Hypertension|Valvular Heart Disease|Congenital Heart Disease|Congestive Heart Failure|Pulmonary Embolism|Acute Coronary Syndrome
Interventions: DIAGNOSTIC_TEST: Measuring Right Ventricular Size and Function
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Specific Infection-Fighting Cells For Prediction of Immune Response to Anti-HIV and Immune-Boosting Medication
Status: WITHDRAWN
Conditions: HIV Infections
Interventions: DRUG: Ritonavir|DRUG: Abacavir sulfate|DRUG: Amprenavir|DRUG: Lamivudine|DRUG: Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Machine Learning Model to Predict HOLS and Mortality After Discharge in Hospitalized Oncologic Patients
Status: UNKNOWN
Conditions: Solid Tumor|Nutrition Related Neoplasm/Cancer|Comorbidities and Coexisting Conditions|Mental Status Change|Artificial Intelligence|Oncology|Tumor|Quality of Life
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Antihypertensive Therapy on Recurrence Risk of Ovarian Cancer for Bevacizumab-associated Hypertension
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer|Antiangiogenic-Associated Hypertension|Adjuvant Bevacizumab|Hypertension
Interventions: DRUG: arm A - angiotensin converting enzyme inhibitors (ACEi)|DRUG: arm B - calcium channel blockers (CCBs)|DRUG: arm R - angiotensin receptor blockers ARB
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: RIGHT IV Pilot Study
Status: COMPLETED
Conditions: Peripheral Intravenous Catheters
Interventions: DEVICE: ViaValve Safety IV Catheter|DEVICE: Insyte Autoguard BC [Blood Control] Shielded IV Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SUBLIVAC FIX Mite Mixture Dose Tolerability Study
Status: COMPLETED
Conditions: House Dust Mite Allergy
Interventions: DRUG: SUBLIVAC FIX Mite mixture|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Depth of Anesthesia and Proteomics
Status: COMPLETED
Conditions: Anesthesia Complication|Immune Suppression
Interventions: DRUG: Deep anesthesia|DRUG: Shallow anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LXE408 for Treatment of Visceral Leishmaniasis in Ethiopia, a Proof of Concept Study
Status: RECRUITING
Conditions: Primary Visceral Leishmaniasis
Interventions: DRUG: LXE408|DRUG: sodium stibogluconate|DRUG: Paromomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictive Value of CHA2DS2VASC Score for Contrast-induced Nephropathy After Primary Percutaneous Coronary Intervention in ST-segment Elevation Myocardial Infarction Patients
Status: COMPLETED
Conditions: Acute ST Segment Elevation Myocardial Infarction
Interventions: DIAGNOSTIC_TEST: serum creatinine and estimated glomerular filtration rate, on daily basis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Double-Blind Randomized Cross-Over Trial Comparing Metabolic Effects of Candesartan, Hydrochlorothiazide and Placebo
Status: COMPLETED
Conditions: Hypertension|Obesity
Interventions: DRUG: Hydrochlorothiazide|DRUG: Placebo|DRUG: Candesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study Evaluating CTX001 in Subjects With Transfusion-Dependent β-Thalassemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Beta-Thalassemia|Thalassemia|Genetic Diseases, Inborn|Hematologic Diseases|Hemoglobinopathies
Interventions: BIOLOGICAL: CTX001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis
Status: RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Breast Carcinoma|Metastatic Malignant Neoplasm in the Brain
Interventions: OTHER: Copper Cu 64-DOTA-Trastuzumab|PROCEDURE: Magnetic Resonance Imaging|DEVICE: Positron Emission Tomography|BIOLOGICAL: Trastuzumab|BIOLOGICAL: Trastuzumab Deruxtecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Zero Fluoroscopic Ablation Versus Conventional Fluoroscopic Ablation for Right Atrial Arrhythmias
Status: COMPLETED
Conditions: Atrial Arrhythmia|Atrial Premature Complexes|Atrial Tachycardia
Interventions: PROCEDURE: Zero-fluoroscopy ablation|PROCEDURE: Conventional fluoroscopy ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Urokinase Versus Video-assisted Thoracoscopic to Treat Complicated Parapneumonic Empyema in Childhood
Status: COMPLETED
Conditions: Empyema|Pneumonia
Interventions: DRUG: Urokinase|PROCEDURE: Video-Assisted Thoracoscopic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-Center Study of GSK2857916 in Combination With Pomalidomide and Dex
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed and/or Refractory Multiple Myeloma
Interventions: DRUG: GSK2857916 with Pomalidomide and Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Helping Patients With Spinal Stenosis Make a Treatment Decision: A Randomized Study Assessing The Benefits of Health Coaching
Status: COMPLETED
Conditions: Spinal Stenosis
Interventions: BEHAVIORAL: Coaching|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Adolescent ORION-16 or ORION-13 Studies
Status: RECRUITING
Conditions: Heterozygous or Homozygous Familial Hypercholesterolemia
Interventions: DRUG: Inclisiran
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Emergency Department Brief Intervention to Increase Carbon Monoxide Detector Use
Status: COMPLETED
Conditions: Intervention-carbon Monoxide Alarm + Educational Tool|Control- Usual Care Flyer on Carbon Monoxide
Interventions: BEHAVIORAL: Educational Tool & Carbon Monoxide Alarm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Pharmacokinetics and Safety of Co-administered Oral Galicaftor, Navocaftor, and ABBV-576 in Healthy Adults for the Treatment of Cystic Fibrosis
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Galicaftor|DRUG: ABBV-576|DRUG: Navocaftor|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to to Assess the Effect of Dapagliflozin When Administered Once a Day Versus Twice a Day on Blood Glucose
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Dapagliflozin|DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fungal Biomarkers to Reduce Duration of Empirical Antifungal Therapy: a Randomized Comparative Study (STAFE)
Status: COMPLETED
Conditions: Fungal Infection|Critical Illness
Interventions: OTHER: Biomarker group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tai Chi-muscle Power Training for Primary School Children With Developmental Coordination Disorder
Status: UNKNOWN
Conditions: Developmental Coordination Disorder
Interventions: BEHAVIORAL: TC-MPT|BEHAVIORAL: TC|BEHAVIORAL: MPT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeting Synovitis in Early Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Polyarthritis
Interventions: OTHER: Musculoskeletal Ultrasound|OTHER: 28 Joint Disease Activity Score
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Bioavailability, Pharmacodynamic Effects, and Safety of Whole and Crushed ALO-01 Compared to Morphine Sulfate Immediate Release (MSIR)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ALO-01|DRUG: MSIR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Safety and Immunogenicity of the Recombinant Subunit Vaccine "GamTBvac" Against the Tuberculosis.
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: Single GamTBvac vaccination (0.25 dose)|BIOLOGICAL: Placebo administration|BIOLOGICAL: Double GamTBvac vaccination (0.25 dose)|BIOLOGICAL: Double GamTBvac vaccination (0.5 dose)|BIOLOGICAL: Double GamTBvac vaccination (1.0 dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of Participants With Lymphoma Who Take R-CHOP and Enzastaurin Compared to Participants Who Take R-CHOP Only
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: enzastaurin|DRUG: rituximab|DRUG: cyclophosphamide|DRUG: doxorubicin|DRUG: vincristine|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Osteopathic Manipulative Medicine in Recovery From Concussions
Status: RECRUITING
Conditions: Concussion, Brain
Interventions: PROCEDURE: Osteopathic manipulative treatment|PROCEDURE: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diurnal Variation of Exogenous Peptides (GH Puls/Jurgita I)
Status: COMPLETED
Conditions: Growth Hormone Deficiency
Interventions: DRUG: Norditropin SimpleXx (growth hormone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Apantamide Combined With Docetaxel and ADT vs. Apantamide Combined With ADT in Patients With High Tumor Burden mHSPC: a Multicenter and Prospective Cohort Study
Status: RECRUITING
Conditions: Cohort Studies
Interventions: DRUG: apantamide+docetaxel+ADT|DRUG: apantamide+ADT treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effects of Analgesia Nociception Index (ANI)-Guided Analgesia on Postoperative Bowel Function.
Status: RECRUITING
Conditions: Postoperative Bowel Function Recovery
Interventions: DEVICE: ANI|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Pain Study Comparing Two Commonly Used Medications to Treat Pain After Bowel Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Ropivacaine|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Polaprezinc Treatment for Enzalutamide- or Abiraterone-resistant CRPC
Status: COMPLETED
Conditions: Castration-resistant Prostate Cancer
Interventions: DRUG: Polaprezinc group|DRUG: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant FOLFOXIRI Versus Immediate Surgery for Stage II and III Colon Cancers
Status: RECRUITING
Conditions: Colon Cancer Stage II|Colon Cancer Stage III
Interventions: DRUG: neoadjuvant chemotherapyI|PROCEDURE: Colectomy|DRUG: adjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Database Survey to Evaluate the Safety of Immune Globulin Subcutaneous (Human), 20% Solution in Participants With Primary Immunodeficiency
Status: NOT_YET_RECRUITING
Conditions: Primary Immunodeficiency Diseases (PID)
Interventions: DRUG: Immune Globulin Subcutaneous (Human), 20% Solution
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-3 (UNITED-3)
Status: RECRUITING
Conditions: Glioblastoma Multiforme, Adult
Interventions: RADIATION: Adaptive, two-phase RT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Mindfulness Based Cognitive Therapy and Mindfulness Based Self-compassion Therapy in a Psoriasis Sample
Status: UNKNOWN
Conditions: Psoriasis
Interventions: BEHAVIORAL: Mindfulness Based Cognitive Therapy|BEHAVIORAL: MBSC - minimal contact|BEHAVIORAL: Mindfulness Based Self Compassion Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Implants Placed With Crestal Sinus Approach Versus Osseodensification in Atrophic Posterior Maxilla
Status: NOT_YET_RECRUITING
Conditions: Implants
Interventions: PROCEDURE: implant placement using crestal sinus approach|PROCEDURE: Implant placement using osseodensification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: I-Gel Versus Disposable Laryngeal Mask (LMA) for General Anesthesia (GA) With Controlled Ventilation
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Insertion of laryngeal mask airway (AuraOnce mask)|DEVICE: Insertion of I-gel airway|OTHER: Measurement of airway pressures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: TSR-042 in Addition to Standard of Care Definitive Radiation for Inoperable Endometrial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Cancer|Cancer of the Endometrium
Interventions: DRUG: TSR-042|RADIATION: Brachytherapy|PROCEDURE: Endometrial biopsy|PROCEDURE: Blood draw for immune response
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiac Safety Study of Entinostat in Men and Women With Advanced Solid Tumors
Status: COMPLETED
Conditions: Neoplasms|Neoplasms, Glandular and Epithelial|Neoplasms by Histologic Type|Bronchial Neoplasms|Lung Neoplasms|Respiratory Tract Neoplasms|Thoracic Neoplasms|Digestive System Neoplasms|Endocrine Gland Neoplasms|Carcinoma, Non-Small-Cell Lung|Lung Diseases|Breast Neoplasms|Breast Diseases|Renal Neoplasm|Solid Tumors
Interventions: DRUG: Entinostat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Insulin Resistance and Androgen Deprivation Therapy
Status: WITHDRAWN
Conditions: Prostate Cancer|Insulin Resistance
Interventions: DRUG: Pioglitazone 30 mg|DRUG: placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Use of Off-the-shelf Natural Killer (NK) Cells (SAR445419) in Relapsed/Refractory Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Acute Myeloid Leukaemia
Interventions: DRUG: SAR445419|DRUG: fludarabine|DRUG: cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban, or Aspirin Plus REGN9933, or Aspirin Plus REGN7508 in Healthy Adult Participants
Status: NOT_YET_RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: Aspirin|DRUG: REGN9933|DRUG: REGN7508|DRUG: Rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Building Empowerment and Coping Outcomes for caNcer Patients, Survivors and Their Caregivers
Status: RECRUITING
Conditions: Cancer|Caregiving Stress|Caregiver Burnout|Survivorship
Interventions: BEHAVIORAL: Cancer Connect Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Microbiologic Alterations of the Conjunctiva of Hot Tub-soaking Ophthalmologists
Status: COMPLETED
Conditions: Conjunctivitis, Bacterial|Keratitis Bacterial
Interventions: BEHAVIORAL: Dunk|OTHER: Exposure to Hot Tub
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: 2.5% and 10% Phenylephrine for Mydriasis in Diabetic Patients With Darkly Pigmented Irides
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: 2.5% or 10% phenylephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Restenosis Intrastent: Bioresorbable Vascular Scaffolds Treatment (RIBS VI)
Status: UNKNOWN
Conditions: Coronary In-stent Restenosis
Interventions: DEVICE: Bioresorbable vascular scaffold
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Accuracy of Self-sampling Versus Healthcare Sampling for Coronavirus-Disease-2019 Detection.
Status: COMPLETED
Conditions: COVID-19 Pandemic
Interventions: DIAGNOSTIC_TEST: Collection of nasal and oropharyngeal specimen for COVID19 antigen test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Analysis of Balance and Functional Hop Tests Used for Return to Sports in Athletes With Lower Extremity Injuries by Dual Task Study
Status: UNKNOWN
Conditions: Athletic Injuries|Knee Injuries|Ankle Injuries|Hip Injuries|Ankle Sprains|Reinjuries
Interventions: PROCEDURE: Dual tasking paradigm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Evaluating a Combination of Immune-based Therapies to Achieve a Remission of HIV Infection
Status: UNKNOWN
Conditions: HIV Infections
Interventions: OTHER: HIVACAR|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Determine the Ability of a New Product Formulation to Remineralize an Early Caries Lesion by an In-situ Study
Status: WITHDRAWN
Conditions: Dental Caries
Interventions: DRUG: Control toothpaste containing no anti-cavity ingredients|DRUG: Experimental toothpaste containing fluoride and amino acid (arginine)|DRUG: Fluoride toothpaste containing fluoride as the anti-cavity ingredient
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Different n-3 Fatty Acid Formulations
Status: COMPLETED
Conditions: Health
Interventions: DRUG: rTG|DRUG: GArTG|DRUG: EE|DRUG: KPL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PROMUS Element Plus US Post-Approval Study
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: PROMUS Element Plus Coronary Stent System|DRUG: Aspirin|DRUG: P2Y12 antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Sargassum Horneri Extract on Patients With Hypersensitivity
Status: COMPLETED
Conditions: Skin Hypersensitivity
Interventions: DIETARY_SUPPLEMENT: Sargassum Horneri Extract group|DIETARY_SUPPLEMENT: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Deep and Superficial Serratus Anterior Plane Block
Status: UNKNOWN
Conditions: Pain Management|Thoracotomy
Interventions: PROCEDURE: Deep Serratus Anterior Plane Block|PROCEDURE: Superficial Serratus Anterior Plane Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chlamydia Tracomatis and Other Lower Genital Tract Infections Among Women With Unexplained Early Miscarriage
Status: COMPLETED
Conditions: Early Pregnancy
Interventions: DIAGNOSTIC_TEST: cervicovaginal culture and qPCR for chlamydial trachomatis and wadallia chondrophila
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: G6PD (Glucose-6-phosphate Dehydrogenase) Study to Evaluate Hemolysis Potential of TFQ (Tafenoquine)
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Chloroquine|DRUG: Primaquine|DRUG: Tafenoquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Maxillomandibular Advancement in the Treatment of Obstructive Sleep Apnea
Status: RECRUITING
Conditions: OSA|OSAS|Apnea, Obstructive Sleep|Orthognathic Surgery
Interventions: PROCEDURE: Maxillomandibular advancement|PROCEDURE: monomaxillary surgery (isolated MaxS)|PROCEDURE: monomandibullary surgery (MandS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Quercetin|OTHER: Placebo - sugar chew
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Population Pharmacokinetics/Pharmacodynamics of Carbapenems in Febrile Neutropenia Patients
Status: NOT_YET_RECRUITING
Conditions: Febrile Neutropenia|Pharmacokinetics|Pharmacodynamic|Carbapenems
Interventions: OTHER: Dose prediction using population pharmacokinetic models
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced Pancreatic Fistula Rate Following Pancreaticoduodenectomy: Trial on Pancreaticogastrostomy Versus Pancreaticojejunostomy
Status: COMPLETED
Conditions: Tumors
Interventions: PROCEDURE: Pancreaticojejunostomy|PROCEDURE: Pancreaticogastrostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Enhance Wellness for Individuals With Long-Term Physical Disabilities
Status: COMPLETED
Conditions: Multiple Sclerosis|Muscular Dystrophy|Post-polio Syndrome|Spinal Cord Injury
Interventions: BEHAVIORAL: Enhance Wellness
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH