pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Netupitant and Palonosetron Hydrochloride in Preventing Chronic Nausea and Vomiting in Patients With Cancer
Status: COMPLETED
Conditions: Malignant Neoplasm|Nausea|Vomiting
Interventions: DRUG: Netupitant|DRUG: Palonosetron|DRUG: Palonosetron Hydrochloride|OTHER: Placebo|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Metabolic Availability of Lysine From Rice
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DIETARY_SUPPLEMENT: Amino Acid Crystalline Lysine Amino Acid Mix|DIETARY_SUPPLEMENT: Cooked Rice containing Lysine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Mechlorethamine Induced Contact Dermatitis Avoidance Study
Status: COMPLETED
Conditions: Cutaneous T-cell Lymphoma|Cutaneous T-cell Lymphoma Stage I|Mycosis Fungoides|Folliculotropic Mycosis Fungoides|Granulomatous Slack Skin|Syringotropic Mycosis Fungoides|Mycosis Fungoides Variant|Transformed Mycosis Fungoides
Interventions: DRUG: Triamcinolone|DRUG: Valchlor 0.016 % Topical Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Upper Extremity Rehabilitation With Virtual Reality in Parkinson's Disease Patients
Status: RECRUITING
Conditions: Parkinson Disease|Virtual Reality|Neurological Rehabilitation|Upper Extremity Dysfunction
Interventions: OTHER: Upper extremity position matching exercises in virtual reality|OTHER: Conventional physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Comparison of Diagnostic TESE and TESA in Non-obstructive Azoospermic
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: extaction|PROCEDURE: testicular sperm extraction|PROCEDURE: testicular sperm aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Adalimumab for the Treatment of Uveitis in Juvenile Idiopathic Arthritis
Status: COMPLETED
Conditions: Uveitis|Juvenile Arthritis
Interventions: DRUG: Anti-tumor necrosis factor alpha monoclonal antibody|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Assess Pharmacokinetic/Pharmacodynamic Profiles and Safety of IVL3001
Status: COMPLETED
Conditions: Androgenetic Alopecia
Interventions: DRUG: Finasteride 1mg Tablet|DRUG: IVL3001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhibitors of Angiotensin II in Proteinuric Mesangioproliferative Glomerulonephritis
Status: COMPLETED
Conditions: IGA Glomerulonephritis
Interventions: DRUG: Ramipril or losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Biomarkers and Molecular Targets Involved on Intervertebral Disc Degeneration and Discogenic Pain
Status: RECRUITING
Conditions: Intervertebral Disc Degeneration|Discogenic Pain|Discogenic Disease
Interventions: OTHER: cell isolation from intervertebral disc tissue and biomarker investigation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: First-in-human Study Aiming to Characterize the Safety, Tolerability, Pharmacokinetic and Preliminary Signs of Activity of ABD-3001 in Refractory or Relapsed AML and High Risk MDS Adult Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia, Adult|Myelodysplastic Syndromes
Interventions: DRUG: ABD-3001|DRUG: ABD-3001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetic Mutation in Recurrent Cervical Cancer
Status: UNKNOWN
Conditions: Recurrent Cervical Cancer|Nucleotide Variant|Copy Number Variation|Insertion-deletion Variation|Genomic Structural Variation|Total Mutation Burden|Microsatellite Instability|PD-1|PD-L1
Interventions: DIAGNOSTIC_TEST: Multi-gene panel testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Tolerability and Effects of AZD0530 in Individuals With or Without a Family History of Alcoholism
Status: COMPLETED
Conditions: Alcoholism
Interventions: DRUG: 125 mg AZD0530|DRUG: 50 mg AZD0530|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intraperitoneal Infusion of EpCAM CAR-T Cell in Advanced Gastric Cancer With Peritoneal Metastasis (WCH-GC-CART)
Status: UNKNOWN
Conditions: Neoplasm, Stomach|Metastases, Neoplasm|Neoplasm Seeding
Interventions: BIOLOGICAL: CAR-T cells targeting EpCAM|BIOLOGICAL: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acetylcholinesterase Inhibition and Orthostatic Hypotension in SCI
Status: COMPLETED
Conditions: Hypotension, Postural
Interventions: DRUG: Pyridostigmine Bromide|DEVICE: Tilt table test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of High Fidelity Simulation for Safety in the Medication Process in Intensive Care
Status: UNKNOWN
Conditions: Learning Process in Nursing Graduation|Compliant Behavior
Interventions: OTHER: High Fidelity Simulation|OTHER: Traditional teaching strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Neuromodulation With Transcranial Direct Current Stimulation (tDCS) to Control Excess Weight
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: DEVICE: Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin and Bevacizumab (Avastin™) With Either Fluorouracil and Leucovorin or Capecitabine in Treating Patients With Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: capecitabine|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AOH1996 for the Treatment of Refractory Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Refractory Malignant Solid Neoplasm|Osteosarcoma|Leiomyosarcomas|Synovial Sarcomas|Ovarian Cancer|Non-Small Cell Lung Cancer|Pancreatic Cancer
Interventions: DRUG: PCNA Inhibitor AOH1996
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Effect of Omadacycline Versus Moxifloxacin in Healthy Adult Volunteers
Status: RECRUITING
Conditions: Healthy Volunteer
Interventions: DRUG: Moxifloxacin Oral Tablet|DRUG: Omadacycline Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Evaluate the Efficacy and Safety of SYSA1901 vs. Perjeta® of HER2-Positive Breast Cancer
Status: RECRUITING
Conditions: HER2-positive Breast Cancer
Interventions: DRUG: SYSA1901|DRUG: Pertuzumab|DRUG: Trastuzumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of SOF/VEL + RBV and SOF/VEL/VOX for 12 Weeks in HCV Subjects With GT3b and Compensated Cirrhosis
Status: UNKNOWN
Conditions: Hepatitis C|Cirrhosis
Interventions: DRUG: Sofosbuvir/Velpatasvir + Ribavirin|DRUG: Sofosbuvir/Velpatasvir/Voxilaprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Dose of Angiotensin-receptor Blocker Valsartan and Genetic Polymorphism on the Post-MI Ventricular Remodeling
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: high dose of valsartan|DRUG: usual dose of valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Muscle Training in Coronary Artery Patients With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome|Coronary Artery Disease
Interventions: DEVICE: Neuromuscular Electrical Stimulation|OTHER: Inspirator Muscle Training|OTHER: Peripheral Muscle Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trajectory of Recovery in the Elderly
Status: COMPLETED
Conditions: Delayed Emergence From Anesthesia|Postoperative Delirium|Postoperative Cognitive Dysfunction
Interventions: PROCEDURE: Functional magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CAR T and PD-1 Knockout Engineered T Cells for Esophageal Cancer
Status: UNKNOWN
Conditions: Advanced Esophageal Cancer
Interventions: BIOLOGICAL: Anti-MUC1 CAR-T cells|BIOLOGICAL: PD-1 knockout Engineered T cells|COMBINATION_PRODUCT: CAR-T combined with PD-1 Knockout T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Myo-inositol, D-chiro-inositol, and D-chiro/Myo-inositol in Gestational Diabetes
Status: UNKNOWN
Conditions: GDM
Interventions: DIETARY_SUPPLEMENT: Myo-inositol|DIETARY_SUPPLEMENT: D-chiro-inositol|DIETARY_SUPPLEMENT: D-Chiro / Myo-inositol|DIETARY_SUPPLEMENT: Placebo
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: M.I.P.O. vs Intramedullary Nailing in Tibia Fractures
Status: UNKNOWN
Conditions: Tibia Fracture
Interventions: PROCEDURE: Minimally Invasive Plate Osteosynthesis|PROCEDURE: intramedullary tibial Nailing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple-dose Study to Evaluate the Safety,Tolerability, Pharmacokinetics and Pharmacodynamics of HSK7653 in T2DM
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: HSK7653 10 mg|DRUG: HSK7653 25 mg|DRUG: HSK7653 50 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Electrolysis Versus Dry Needling in Levator Scapulae
Status: COMPLETED
Conditions: Trigger Point Pain, Myofascial|Myofascial Pain
Interventions: OTHER: Percutaneous electrolysis|OTHER: Dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Serplulimab Combined With CAPEOX + Celecoxib as Neoadjuvant Treatment for Locally Advanced Rectal Cancer
Status: RECRUITING
Conditions: pMMR|MSS|MSI-L|Locally Advanced Rectal Carcinoma
Interventions: DRUG: Serplilumab|DRUG: Capecitabine|DRUG: Oxaliplatin|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Liraglutide in the Treatment of Obesity Combined With Metabolism Associated Fatty Liver Disease
Status: RECRUITING
Conditions: Non-alcoholic Fatty Liver Disease|Obesity
Interventions: DRUG: Liraglutide|DRUG: Orlistat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Adult ADHD With Atomoxetine or Atomoxetine and Buspar
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: Atomoxetine|DRUG: Buspirone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Comparison of Minocycline Microgranules Versus Lymecycline in the Treatment of Mild to Moderate Acne
Status: UNKNOWN
Conditions: Mild to Moderate Acne
Interventions: DRUG: Minocycline vs Lymecycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hepatic Resection Versus TACE+RFA for BCLC Stage B Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: Hepatic resection|PROCEDURE: TACE|PROCEDURE: RFA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Leucine on Body Weight
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: DIETARY_SUPPLEMENT: L-Leucine 8gr|OTHER: Liquid meal|DIETARY_SUPPLEMENT: L-Leucine 4g
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Continuous Glucose Monitoring on Maternal and Infant's Outcomes in Gestational Diabetes
Status: NOT_YET_RECRUITING
Conditions: Gestational Diabetes Mellitus|Continuous Glucose Monitoring
Interventions: DEVICE: Continuous glucose monitor|BEHAVIORAL: Perinatal nursing care for gestational diabetes|OTHER: Blood glucose meters (BGM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Black Currant on Postprandial Glucose Metabolism
Status: COMPLETED
Conditions: Postprandial Hyperglycemia|Prediabetic State
Interventions: OTHER: Black currant|OTHER: Black currant-quinoa product|OTHER: Quinoa base
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Breath Analysis for the Detection of Invasive Fungal Infections
Status: NOT_YET_RECRUITING
Conditions: Leukemia|Leukemia, Myeloid|Leukemia, Lymphoblastic|Neutropenia|Chemotherapy-induced Neutropenia|Invasive Fungal Infections|Invasive Pulmonary Aspergillosis
Interventions: DIAGNOSTIC_TEST: Secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioavailability and Vascular Effects of Apple Polyphenols
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Apple extract delivering 70 mg epicatechin|OTHER: Apple extract delivering 140 mg epicatechin|OTHER: Apple granules delivering 70 mg epicatechin|OTHER: Water delivering no epicatechin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Extension Study of the Efficacy of the GSK 580299 Vaccine in Japanese Women Vaccinated in the Primary NCT00316693 Study
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: PROCEDURE: Liquid-based cytology (LBC) sampling|PROCEDURE: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: High Dose Rate Prostate Brachytherapy as Salvage for Locally Recurrent Prostate Cancer Previously Treated With External Beam Radiotherapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: RADIATION: High dose rate (HDR) brachytherapy using Iridium 192 radioactive seeds
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Immunogenicity and Safety Study of Gardasil® in Chinese Subjects (V501-030)(COMPLETED)
Status: COMPLETED
Conditions: Papillomavirus Infections
Interventions: BIOLOGICAL: Quadrivalent Human Papillomavirus (HPV, Types 6, 11, 16, 18) Recombinant Vaccine (Gardasil®)|BIOLOGICAL: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Furmonertinib as Neoadjuvant Therapy for Resectable Stage Ⅱ-ⅢB EGFR Sensitive Mutant NSCLC
Status: NOT_YET_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Furmonertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Observe the Efficacy and Safety by Comparing Chemotherapy(Docetaxel, Oxaliplatin Plus S1 ) Followed With Radical Resection Versus Chemotherapy Alone in Advanced Gastric Cancer With Single Non-curable Factor.
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: PROCEDURE: Gastrectomy|DRUG: oxaliplatin|DRUG: S1|DRUG: Docetaxel
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: DAHANCA 20 Palliative Radiotherapy for Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Neoplasms|Recurrence|Neoplasms, Second Primary
Interventions: PROCEDURE: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Study of Docetaxel + Ramucirumab or Placebo in Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: ramucirumab (IMC-1121B)|DRUG: docetaxel|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating 7-Valent Pneumococcal Conjugate Vaccine in Healthy Infants
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: 7-valent pneumococcal conjugate vaccine|BIOLOGICAL: Diptheria and tetanus toxoids and accelular pertussis vaccine (DTaP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sexuality of the Man Whose Couple is Taken Care of in Medical Assistance to Procreation. Study of Case Witnesses
Status: UNKNOWN
Conditions: Men in Relation|Couple Whose Taken Care in Medical Assisted to Reproduction
Interventions: OTHER: IIEF (International Index of Erectile Function questionnaire )
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sintilimab Combination Therapy Plus IMRT in Nasopharyngeal Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Sintilimab, bevacizumab, gemcitabine|RADIATION: IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Tolerability and Pharmacokinetics of Roflumilast, 250μg and 500μg, as add-on to Standard COPD Treatment to Treat Severe COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Roflumilast|DRUG: Roflumilast Placebo|DRUG: Standard of Care COPD Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Evolocumab on Saphenous Vein Graft Patency Following Coronary Artery Bypass Surgery
Status: UNKNOWN
Conditions: Coronary Artery Bypass Graft Surgery|Atherosclerosis|Vein Occlusion
Interventions: DRUG: Evolocumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Genetic Counselling in the Prevention of Mental Health Consequences of Cannabis Use
Status: RECRUITING
Conditions: Mental Illness|Schizophrenia|Bipolar Disorder|Major Depressive Disorder|Cannabis Use|Psychosis
Interventions: BEHAVIORAL: Genetic counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Can Augmentation Index (AIx) be Used to Predict Hypotension After Spinal Anesthesia?
Status: COMPLETED
Conditions: Hypotension|Cesarean Delivery
Interventions: DEVICE: AIx measurement with a Sphygmacor TM|DEVICE: AIx measurement with a Sphygmacor TM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phitys I™ Percutaneous Left Ventricular Assist System Study
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: Percutaneous Ventricular Assist System（Phigine Medical）|DEVICE: intra-aortic balloon pump (IABP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Absorption of Hydrolyzed or Intact Proteins in Morbid Obese Patients After the Roux Y Gastric Bypass
Status: RECRUITING
Conditions: Morbid Obesity
Interventions: DIETARY_SUPPLEMENT: Hydrolyzed Proteins|DIETARY_SUPPLEMENT: Intact proteins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prevention of S. Aureus Pneumonia Study in Mechanically Ventilated Subjects Who Are Heavily Colonized With S. Aureus.
Status: TERMINATED
Conditions: Pneumonia, Ventilator-associated|Pneumonia, Staphylococcal
Interventions: DRUG: ASN100|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Molecular Epidemiology of Lung Adenocarcinoma in Multi-ethnic Asian Phenotype
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: OTHER: Characterise the molecular epidemiology of lung adenocarcinoma in multi-ethnic asian phenotypes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Donor Bone Marrow Transplant in Treating Young Patients With Cancer or a Non-Cancerous Disease
Status: COMPLETED
Conditions: Kidney Cancer|Leukemia|Lymphoma|Myelodysplastic Syndromes|Neuroblastoma|Sarcoma
Interventions: BIOLOGICAL: filgrastim|PROCEDURE: allogeneic bone marrow transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Surgery and Niraparib in Secondary Recurrent Ovarian Cancer (SOC-3 Trial)
Status: RECRUITING
Conditions: Ovarian Cancer Recurrent|Fallopian Tube Cancer|Primary Peritoneal Carcinoma
Interventions: PROCEDURE: Surgery|DRUG: carboplatin/taxane, carboplatin/gemcitabine, cisplatin/gemcitabine, liposome doxorubicin/carboplatin...|DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of a Novel Approach for the Prevention of Deep Venous Thrombosis After Total Knee Replacement
Status: COMPLETED
Conditions: Deep Venous Thrombosis
Interventions: DEVICE: active ankle pumping with a regular watch alarm|DEVICE: intermittent pneumatic compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: To Evaluate Safety and the Pharmacokinetic Characteristics After Oral Administration of HT-003 Compared With Choline Alfoscerate Capsule in Healthy Adult Male Volunteers
Status: COMPLETED
Conditions: Healthy Male
Interventions: DRUG: Choline CR 600mg|DRUG: Gliatilin 400mg|DRUG: Choline CR 600mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DRIIVE (Data and Research on Interventions to Improve the Vehicular Environment)
Status: COMPLETED
Conditions: Vehicular Environment
Interventions: DEVICE: HEPA air purifier|BEHAVIORAL: questionnaires|OTHER: Log-book|OTHER: Urine sample
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Fractionated Stereotactic Radiosurgery to Treat Large Brain Metastases
Status: COMPLETED
Conditions: Brain Cancer|Neoplasm Metastasis|Cancer of Brain and Nervous System|Metastatic Malignant Neoplasm to Brain
Interventions: RADIATION: Fractionated Stereotactic Radiosurgery (SRS)|PROCEDURE: Surgical resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of a Cytomegalovirus (CMV) Vaccine (ASP0113) in CMV-Seropositive and CMV-Seronegative Healthy Subjects and CMV-Seronegative Dialysis Patients
Status: COMPLETED
Conditions: Dialysis|Healthy Subjects|Cytomegalovirus Infection
Interventions: DRUG: ASP0113|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Effect of a Multi-component Weight Management Program on Appetite, Food Preference and Body Weight
Status: COMPLETED
Conditions: Overweight|Obesity|Sedentary Lifestlye
Interventions: BEHAVIORAL: Weight management program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Laparoscopic Ventral Mesh Rectopexy Versus Delorme's Operation in Management of Complete Rectal Prolapse
Status: COMPLETED
Conditions: Complete Rectal Prolapse
Interventions: PROCEDURE: Laparoscopic ventral mesh Rectopexy|PROCEDURE: Delorme's procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers of Acrylamide, Glycidol, POPs, PFAS and Disease Outcomes and OMICs Signatures
Status: COMPLETED
Conditions: Disease|Cardiovascular Diseases|Cancer|Environmental Exposure
Interventions: OTHER: Biomarkers of acrylamide, glycidol, POPs, PFAS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Study to Test the Effects of Ruxolitinib And Thalidomide Combination for Patients With Myelofibrosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelofibrosis
Interventions: DRUG: Ruxolitinib|DRUG: Thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: T-cell Therapy in Combination With Nivolumab, Relatlimab and Ipilimumab for Patients With Metastatic Ovarian Cancer
Status: TERMINATED
Conditions: Metastatic Ovarian Cancer|Metastatic Fallopian Tube Cancer|Peritoneal Cancer
Interventions: DRUG: Ipilimumab|DRUG: Cyclophosphamid|DRUG: Fludarabine Phosphate|BIOLOGICAL: Tumor Infiltrating Lymphocytes infusion|DRUG: Nivolumab|DRUG: Relatlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bloodletting Puncture in the Treatment of Acute Ischemic Stroke
Status: UNKNOWN
Conditions: Acute Ischemic Stroke
Interventions: OTHER: Western medicine conventional treatment +Bloodletting puncture|OTHER: Western medicine conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Investigate the Long-term Safety, Tolerability, and Efficacy of Ponesimod in Patients With Relapsing-remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Ponesimod 10 mg|DRUG: Ponesimod 20 mg|DRUG: Ponesimod 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Part Two of Novel Adoptive Cellular Therapy With SARS-CoV-2 Specific T Cells in Patients With Severe COVID-19
Status: UNKNOWN
Conditions: COVID-19
Interventions: BIOLOGICAL: SARS-CoV-2 Specific T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Levetiracetam Versus Valproate in Idiopathic Generalized Tonic-clonic Seizures
Status: COMPLETED
Conditions: Epilepsy, Idiopathic Generalized
Interventions: DRUG: Levetiracetam|DRUG: Valproate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Post-acute Pickwick Study" (Postacute-Pick-2020)
Status: WITHDRAWN
Conditions: Acute on Chronic Hypercapnic Respiratory Failure|Obesity Hypoventilation Syndrome (OHS)
Interventions: PROCEDURE: "Lifestyle modifications" group (Control)|PROCEDURE: Automatic NIV|PROCEDURE: CPAP treatment group|PROCEDURE: NIV treatment groups
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Sexual Health of Patients Treated for Breast Cancer and Followed up in the Observatory of Fertility at Jeanne de Flandre Hospital.
Status: RECRUITING
Conditions: Breast Cancer|Breast Neoplasms|Breast Carcinoma|Breast Tumor
Interventions: OTHER: Self-administered questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Active Tissue Release Techniques on Groin Pain in 2nd Trimester of Pregnancy
Status: NOT_YET_RECRUITING
Conditions: Groin Strain
Interventions: OTHER: Active release techniques|OTHER: Relaxation exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Mobilization (Plerixafor) and Immunologic Reset in Type 1 Diabetes (T1DM)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Plerixafor|DRUG: Alemtuzumab|DRUG: Anakinra|DRUG: Etanercept|DRUG: Liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate an 8 mg Aflibercept (EYLEA®) Prefilled Syringe (PFS)
Status: COMPLETED
Conditions: Diabetic Macular Edema (DME)|Neovascular Age-Related Macular Degeneration (nAMD)
Interventions: DRUG: aflibercept 8 mg PFS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EXTended pRotective Curtain Under Table to Reduce Operator RAdiation Dose in Percutaneous Coronary Procedures
Status: COMPLETED
Conditions: Radiation|X-rays; Effects|Coronary Disease
Interventions: DEVICE: SCUT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About How Much Emodepside Gets Absorbed in the Blood and How Food Affects Its Absorption When Given as a New Type of Tablet to Healthy Participants
Status: RECRUITING
Conditions: Soil-transmitted Helminth Infection|Onchocerciasis (River Blindness)
Interventions: DRUG: BAY 44-4400|DRUG: BAY 44-4400
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Validation of the STarT Back Screening Tool in the Military
Status: COMPLETED
Conditions: Low Back Pain|Lumbago|Radiculopathy|Intervertebral Disc Disorder
Interventions: PROCEDURE: Risk Stratified Care|PROCEDURE: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SB-715992 in Treating Patients With Acute Leukemia, Chronic Myelogenous Leukemia, or Advanced Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Acute Undifferentiated Leukemia|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Acute Promyelocytic Leukemia (M3)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Blastic Phase Chronic Myelogenous Leukemia|de Novo Myelodysplastic Syndromes|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Refractory Anemia With Excess Blasts|Refractory Anemia With Excess Blasts in Transformation|Relapsing Chronic Myelogenous Leukemia|Secondary Acute Myeloid Leukemia|Secondary Myelodysplastic Syndromes|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: ispinesib|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Non-surgical Periodontal Treatment on HbA1c in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Chronic Periodontitis|Type 2 Diabetes Mellitus
Interventions: PROCEDURE: Nonsurgical periodontal treatment|PROCEDURE: Dental Prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peppermint Inhalation Versus Swedish Massage on Chemotherapy Induced-Nausea and Vomiting in Children With Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BEHAVIORAL: Peppermint Inhalation|BEHAVIORAL: Swedish Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of NVL-655 in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)
Status: RECRUITING
Conditions: Locally Advanced Solid Tumor|Metastatic Solid Tumor
Interventions: DRUG: NVL-655
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Tracheal Suction During Extubation in Intensive Care Unit Decrease Functional Residual Capacity
Status: COMPLETED
Conditions: Critically Ill|Extubation|Intensive Care Unit
Interventions: PROCEDURE: no tracheal suction|PROCEDURE: tracheal suction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sealed Therapeutic Shoe as Treatment of Diabetic Foot Ulcers
Status: RECRUITING
Conditions: Diabetic Foot
Interventions: DEVICE: Sealed therapeutic shoe|DEVICE: Total contact cast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Dapagliflozin in Patients With Non-alcoholic Steatohepatitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-alcoholic Steatohepatitis
Interventions: DRUG: Dapagliflozin 10Mg Tab|DRUG: Pioglitazone 30 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The NIPA Study Naloxegol Administration to Prevent Opioids Induced Gastrointestinal Motility Disturbance in Brain Injured PAtients
Status: RECRUITING
Conditions: Brain Injuries
Interventions: DRUG: Naloxegol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerance of Increased Doses of HRS-1780 Tablets in Healthy Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Kidney Disease
Interventions: DRUG: HRS-1780 table or placebo|DRUG: HRS-1780 table or placebo|DRUG: HRS-1780 table or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Investigating the Effect of Drugs Used to Treat Osteoporosis on the Progression of Calcific Aortic Stenosis.
Status: COMPLETED
Conditions: Calcific Aortic Stenosis
Interventions: DRUG: Denosumab|DRUG: Alendronic Acid|DRUG: Denosumab Placebo|DRUG: Alendronic Acid Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab and Ixabepilone in Treating Women With HER2-Positive Metastatic Breast Cancer
Status: TERMINATED
Conditions: HER2-positive Breast Cancer|Recurrent Breast Cancer|Stage IV Breast Cancer
Interventions: BIOLOGICAL: trastuzumab|DRUG: ixabepilone|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Response Duration and Toxicity of Rituximab, Fludarabine, and Cyclophosphamide (RFC) as 1st Line Treatment and Rituximab (R) in Maintenance Treatment in Follicular Non Hodgkin (FNH) Lymphoma
Status: COMPLETED
Conditions: Non Hodgkin Lymphoma
Interventions: DRUG: Rituximab Fludarabine Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study of Recombinant Anti-IL-17A Humanized Monoclonal Antibody in Chinese Participants With Moderate-to-Severe Plaque Psoriasis
Status: RECRUITING
Conditions: Psoriasis
Interventions: DRUG: 608 Q2W|DRUG: 608 Q4W|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aerosolized Azacytidine as Epigenetic Priming for Bintrafusp Alfa-Mediated Immune Checkpoint Blockade in Patients With Unresectable Pulmonary Metastases From Sarcomas, Germ Cell Tumors, or Epithelial Malignancies
Status: WITHDRAWN
Conditions: Sarcomas|Melanomas|Germ Cell Tumors|Epithelial Malignancies (Excluding Lung and Renal Cell Carcinomas)|Pulmonary Metastases
Interventions: DEVICE: AeroEclipse II Breath Actuated Nebulizer|DRUG: Bintrafusp alfa|DRUG: Azacytidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proton Radiation Therapy in Treating Patients With Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: PROCEDURE: Proton Beam Radiation Therapy|OTHER: Quality-of-Life assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Moisturising Cream With or Without Vitamin E and Urea Cream in Palmar-plantar Erythrodysesthesia
Status: RECRUITING
Conditions: Palmar-Plantar Erythrodysesthesia|Palmar-Plantar Erythrodysesthesia Due to Cytotoxic Therapy
Interventions: OTHER: Moisturising cream with vitamin E concentrate|OTHER: Moisturising cream without vitamin E concentrate|OTHER: Urea cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Innovative Mental Health Virtual Ward: Evaluation of Patient-Centered Outcomes
Status: RECRUITING
Conditions: Mental Health Disorder|Mental Health Impairment|Psychiatric Emergency|Crisis; Emotional
Interventions: BEHAVIORAL: Virtual crisis stabilization support with a multi-disciplinary team
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Diagnostic Significance of Endothelial Dysfunction and Myocardial Contractility in Patients With AML
Status: RECRUITING
Conditions: Acute Myeloid Leukemia, Adult|Cardiotoxicity|Endothelial Dysfunction
Interventions: DIAGNOSTIC_TEST: History taking|DIAGNOSTIC_TEST: Anthropometry|DIAGNOSTIC_TEST: Complete blood count|DIAGNOSTIC_TEST: Biochemical blood test|DIAGNOSTIC_TEST: Coagulogram|DIAGNOSTIC_TEST: Immunoenzymatic analysis of the level of endothelin-1, asymmetric dimethylarginine|DIAGNOSTIC_TEST: Stress echocardiography with the definition of global longitudinal deformation of the myocardium|DIAGNOSTIC_TEST: Triplex scanning of neck vessels|DIAGNOSTIC_TEST: Electrocardiography|DIAGNOSTIC_TEST: Ultrasound of the abdominal cavity (with calculation of the area of the spleen) and lymph nodes|DIAGNOSTIC_TEST: Cytogenetic examination of the bone marrow to determine genetic abnormalities.|DIAGNOSTIC_TEST: Cytological examination of bone marrow cells with cytochemical examination|DIAGNOSTIC_TEST: Immunophenotypic examination of the bone marrow by flow cytometry|DIAGNOSTIC_TEST: Determination of the presence of a FLT3 mutation using the PCR Method|DIAGNOSTIC_TEST: laser Doppler flowmetry
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Arthroscopic Versus Open Brostrom for Ankle Instability
Status: RECRUITING
Conditions: Ankle Sprains|Instability, Joint|Ligament Injury|Surgery
Interventions: PROCEDURE: Arthroscopic Brostrom|PROCEDURE: Open Brostrom
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Residual Shunt After Patent Foramen Ovale Device Closure in Patients With Cryptogenic Stroke
Status: COMPLETED
Conditions: Patent Foramen Ovale|Closure; Foramen Ovale
Interventions: DEVICE: Amplatzer® PFO occluder or Gore® Septal Occluder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 1 Study of Ibrutinib and Immuno-Chemotherapy Using Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib,Rituximab (TEDDI-R) in Primary CNS Lymphoma
Status: RECRUITING
Conditions: Primary Central Nervous System Lymphoma
Interventions: DRUG: Isavuconazole|DRUG: TEDDI|BIOLOGICAL: Rituximab|DRUG: Cytarabine|DRUG: TEDD|DRUG: Ibrutinib (Arms 2, 3 and 4)|DRUG: Methotrexate|DRUG: Ibrutinib (Arm 1 - Closed with Amendment G)|DRUG: Ibrutinib (Arm 4)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quality of Life in Patients Treated for Tongue and/or Jaw Neoplasia Before and After Speech Therapy
Status: COMPLETED
Conditions: Tongue Cancer|Jaw Cancer|Oral Cancer|Intelligibility, Speech
Interventions: OTHER: Speech-language guidance|OTHER: Speech therapy exercises for swallowing|OTHER: Speech therapy exercises for speech
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MDMA-Assisted Psychotherapy in Veterans With Combat-Related, Refractory PTSD
Status: RECRUITING
Conditions: Post Traumatic Stress Disorder|Combat Stress Disorders
Interventions: DRUG: 3,4-methylenedioxymethamphetamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Remifentanil on Electroencephalographic BAR Index During Propofol Anaesthesia
Status: COMPLETED
Conditions: Depth of Anaesthesia
Interventions: DRUG: remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluating the Safety and Immune Response to an HIV Vaccine in Healthy, HIV-Uninfected Adults Who Have Participated in Previous HIV Vaccine Clinical Trials and in Adults Who Have Not Participated in Previous HIV Vaccine Clinical Trials
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: Sub C gp140 Vaccine|BIOLOGICAL: MF59C.1 Adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dose-finding Study to Evaluate the Safety, Tolerability, PK, and PD of CK-3773274 in Adults With HCM
Status: COMPLETED
Conditions: Hypertrophic Cardiomyopathy (HCM)
Interventions: DRUG: CK-3773274 (5 - 15 mg)|DRUG: CK-3773274 (10 - 30 mg)|DRUG: Placebo for CK-3773274
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improving the Treatment for Women With Early Stage Cancer of the Uterus
Status: ACTIVE_NOT_RECRUITING
Conditions: Complex Endometrial Hyperplasia With Atypia|Grade 1 Endometrial Endometrioid Adenocarcinoma
Interventions: DRUG: Levonorgestrel|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I, Open-Label, Dose-Escalation Study of a Human Monoclonal Antibody, VRC-HIVMAB091-00-AB (N6LS), Administered Intravenously or Subcutaneously With or Without Recombinant Human Hyaluronidase PH20 (rHuPH20)
Status: COMPLETED
Conditions: HIV Antibodies
Interventions: BIOLOGICAL: VRC-HIVMAB091-00-AB|BIOLOGICAL: rHuPH20
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Vitamin B1 in Type 1 Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Placebo|DRUG: Benfotiamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT