pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Evaluate the Effects of Ibrutinib on Cardiac Repolarization in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ibrutinib|DRUG: Moxifloxacin|DRUG: Ibrutinib-matching placebo|DRUG: Moxifloxacin-matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bil. LR Rec. Using Standard Tables VS Reduced Numbers in Intermittent Exo. in Children Under 6
Status: UNKNOWN
Conditions: Alternating Exotropia
Interventions: PROCEDURE: Standard Recession|PROCEDURE: Reduced Recession
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Enteric-Coated Mycophenolate Sodium (EC-MPS) in Kidney Transplant Recipients
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: EC-MPS, Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of the Combination of Irinotecan and POF (POFI) and Tislelizumab in Advanced Gastric Cancer
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Tislelizumab|DRUG: Oxaliplatin|DRUG: Levo-Leucovorin|DRUG: 5-fluorouracil|DRUG: Irinotecan Hydrochloride|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of the Surgisis Biodesign Vesico-Vaginal Fistula Plug
Status: COMPLETED
Conditions: Vesico-vaginal Fistula
Interventions: DEVICE: Surgisis Biodesign (Vesico-vaginal fistula plug)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tongue Edema Caused by Intubation Tube in Intensive Care Unit Patients
Status: COMPLETED
Conditions: Tongue Edema|Tongue Enlarged|Mechanical Ventilation Complication|Intubation Complication
Interventions: DIAGNOSTIC_TEST: Measuring tongue cross-sectional area by submental ultrasonography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of Direct Home Delivery of Colorectal Cancer Screening Kit Without Pre-ordering
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: OTHER: CRC screening invitation not including the screening test.|OTHER: Mailing of FIT with invitation|OTHER: Information letter before invitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Feasibility of Implantation of Cemented Femoral Stem for Osteoporotic Femoral Neck Fracture in Elderly Patients
Status: UNKNOWN
Conditions: Femoral Neck Fracture
Interventions: PROCEDURE: cemented femoral stem|DEVICE: cannulated compression screws
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Paracervical Block Versus Lidocaine Spray During Endometrial Biopsy
Status: COMPLETED
Conditions: Endometrial Biopsy|Abnormal Uterine Bleeding
Interventions: DRUG: paracervical block with 1%lidocaine|DRUG: 10%lidocaine spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: GSK1358820 (Botulinum Toxin A) PhIII DB & OL Study in Patients With Axillary Hyperhidrosis
Status: COMPLETED
Conditions: Hyperhidrosis
Interventions: DRUG: GSK1358820|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Local Multimodal Injection Versus Regional Anesthesia in Controlling Pain for Treating Rotational Ankle Fractures
Status: ENROLLING_BY_INVITATION
Conditions: Ankle Fractures
Interventions: DRUG: Regional anesthesia group|DRUG: Local multimodal analgesia group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Solifenacin and Oxybutynin in the Treatment of Overactive Bladder
Status: UNKNOWN
Conditions: Overactive Bladder
Interventions: DRUG: Solifenacin|DRUG: Oxybutynin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BNT162b2 Vaccination With 2 Doses in COVID-19 Negative Volunteers and With a Single Dose in COVID-19 Positive Volunteers
Status: COMPLETED
Conditions: Healthy|Immunization; Infection
Interventions: BIOLOGICAL: 3 doses of BNT162b2 vaccine|BIOLOGICAL: 2 dose of BNT162b2 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Next Generation Sequencing Versus Traditional Cultures for Clinically Infected Penile Implants: Impact of Culture Identification on Outcomes
Status: RECRUITING
Conditions: Penile Implantation|Infections
Interventions: DIAGNOSTIC_TEST: Next-Generation DNA Sequencing|DIAGNOSTIC_TEST: Standard Culture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BMS-986141 in Healthy Subjects
Status: COMPLETED
Conditions: Thrombosis
Interventions: DRUG: BMS-986141|DRUG: Placebo|DRUG: Aspirin|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Prospective Feasibility Study Using ctDNA to Tailor Neoadjuvant Chemotherapy for Patients With Colorectal or Appendiceal Adenocarcinoma
Status: RECRUITING
Conditions: Appendiceal Adenocarcinoma|Colorectal
Interventions: PROCEDURE: Circulating tumoral DNA directed neoadjuvant therapy arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid Intravascular Cooling in Myocardial Infarction as Adjunctive to Percutaneous Coronary Intervention
Status: COMPLETED
Conditions: Acute Anterior Myocardial Infarction
Interventions: DEVICE: Endovascular cooling by the Celsius Control System|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AK001
Status: COMPLETED
Conditions: Atopy
Interventions: DRUG: AK001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ES101 (PD-L1x4-1BB Bispecific Antibody) in Patients With Advanced Malignant Thoracic Tumors
Status: WITHDRAWN
Conditions: Thoracic Tumors|Non-small Cell Lung Cancer|Small Cell Lung Cancer
Interventions: DRUG: ES101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest of PHARMaceutical Conciliation to Understand Drug Interactions, Phytotherapy, and Targeted Therapies in Chronic Myeloid Leukemia
Status: RECRUITING
Conditions: Chronic Myeloid Leukemia
Interventions: OTHER: Pharmaceutical intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate Lenvatinib Plus Tislelizumab for Locally Advanced Unresectable or Metastatic Hepatocellular Carcinoma With Hepatitis B Virus Infection and Biomarker Analyses
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Lenvatinib at a dose of 8 mg or 12 mg based on body weight + tislelizumab for one 21-day cycle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HOPE (Home-based Oxygen [Portable] and Exercise) for Patients on Long Term Oxygen Therapy (LTOT)
Status: UNKNOWN
Conditions: Exercise Therapy|Physical Activity|Respiratory Failure|Oxygen Inhalation Therapy
Interventions: OTHER: Home-based physiotherapy program|DEVICE: Prescription of a Portable Oxygen Concentrator (POC) device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Increasing the Temporal Window in Individuals With Alcohol Use Disorder
Status: ACTIVE_NOT_RECRUITING
Conditions: Alcohol Use Disorder
Interventions: BEHAVIORAL: Episodic Future Thinking|BEHAVIORAL: Control Episodic Thinking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Positron Emission Tomography for Detecting Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: PROCEDURE: positron emission tomography|PROCEDURE: radionuclide imaging|RADIATION: fludeoxyglucose F 18
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Recombinant Human IL-18 and Ofatumumab After PBSCT for Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Ofatumumab combined with SB-485232
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Shoulder
Status: RECRUITING
Conditions: Osteoarthritis
Interventions: BIOLOGICAL: [StroMed + platelet rich plasma (PRP)]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Experimental Trial of rhIFNα Nasal Drops to Prevent 2019-nCOV in Medical Staff
Status: UNKNOWN
Conditions: 2019 Novel Coronavirus Infection
Interventions: DRUG: recombinant human interferon Alpha-1b|DRUG: thymosin alpha 1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Probiotic Prophylaxis of Hirschprung's Disease Associated Enterocolitis (HAEC)
Status: COMPLETED
Conditions: Hirschsprung Disease
Interventions: DRUG: VSL#3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Tryptophan for Impaired AhR Signaling in Celiac Disease
Status: RECRUITING
Conditions: Tryptophan Metabolism Alterations|Celiac Disease
Interventions: DRUG: L-Tryptophan|DRUG: Freedom SimpleCap Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ScreenPlus: A Comprehensive, Flexible, Multi-disorder Newborn Screening Program
Status: ENROLLING_BY_INVITATION
Conditions: Acid Sphingomyelinase Deficiency|Ceroid Lipofuscinosis, Neuronal, 2|Cerebrotendinous Xanthomatosis|Fabry Disease|GM1 Gangliosidosis|Gaucher Disease|Lysosomal Acid Lipase Deficiency|Metachromatic Leukodystrophy|Mucopolysaccharidosis II|Mucopolysaccharidosis III-B|Mucopolysaccharidosis IV A|Mucopolysaccharidosis VI|Mucopolysaccharidosis VII|Niemann-Pick Disease, Type C
Interventions: DIAGNOSTIC_TEST: Confirmatory Testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Evaluation of the Panbio™ COVID-19/Flu A&B Panel to Support Home Use
Status: COMPLETED
Conditions: COVID-19|Influenza A|Influenza Type B
Interventions: DIAGNOSTIC_TEST: Panbio™ COVID-19/Flu A&B Panel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Learning to BREATHE: A Randomized Controlled Trial to Lower Diabetes Risk in Adolescent Girls
Status: COMPLETED
Conditions: Type 2 Diabetes|Depression|Obesity
Interventions: BEHAVIORAL: Learning 2 BREATHE|BEHAVIORAL: Colorado Blues
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Compare the Tolerance of Clindamycin 1% /Benzoyl Peroxide (BPO) 5% Gel to Clindamycin 1.2%/ BPO 2.5% Topical Medications
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Clindamycin and BPO 5% gel|DRUG: Clindamycin phosphate and benzoyl peroxide 2.5% gel.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ME-401 in Subjects With CLL/SLL, FL, and B-cell Non Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia (CLL)|Small Lymphocytic Lymphoma (SLL)|Follicular Lymphoma (FL)|Marginal Zone B Cell Lymphoma|Diffuse Large B-cell Lymphoma (DLBCL)|High Grade Non-Hodgkin's Lymphoma|Mantle Cell Lymphoma (MCL)
Interventions: DRUG: ME-401|DRUG: Rituximab|DRUG: Zanubrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Administration of Tirofiban in Patients Treated With Tenecteplase for Acute Ischemic Stroke
Status: NOT_YET_RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Tenecteplase plus Tirofiban|DRUG: Tenecteplase plus Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Advancing Brigatinib Properties in ALK+ NSCLC Patients by Deep Phenotyping
Status: ACTIVE_NOT_RECRUITING
Conditions: NSCLC
Interventions: DRUG: Brigatinib|DRUG: Tyrosine kinase inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Pitavastatin Treatments on the Plasma Lgi3 Level in the Patients With Dyslipidemia
Status: COMPLETED
Conditions: Dyslipidemias
Interventions: DRUG: Treatment of pitavastatin 4 mg qd for 12 weeks|BEHAVIORAL: Life-style modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Multiple-Dose Safety Study Of RN316 For TheTreatment Of Hypercholesterolemia
Status: WITHDRAWN
Conditions: Hypercholesterolemia|Dyslipidemia
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: 1 mg/kg every 2 weeks|BIOLOGICAL: 2 mg/kg every 4 weeks|BIOLOGICAL: 4 mg/kg every 4 weeks|BIOLOGICAL: 4 mg/kg every 8 weeks|BIOLOGICAL: 8 mg/kg every 8 weeks|BIOLOGICAL: 12 mg/kg every 8 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Acute Myeloid Leukemia (AML) in Adults 50 to 70 Years, Study of Two Anthracyclines and the Interest of Maintenance Treatment With Interleukin 2
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: chemotherapy (Aracytine + Daunorubicin)|DRUG: chemotherapy (Aracytine + Daunorubicin)|DRUG: chemotherapy (Aracytine + Daunorubicin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Velusetrag in Diabetic or Idiopathic Gastroparesis
Status: COMPLETED
Conditions: Gastroparesis
Interventions: DRUG: velusetrag dose 1|DRUG: velusetrag dose 2|DRUG: velusetrag dose 3|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antiviral Activity of and Resistance to Lamivudine in Combination With Zidovudine, Stavudine, or Didanosine
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Lamivudine|DRUG: Stavudine|DRUG: Zidovudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: MHH-HCV-NPM-Neuropsychiatric Manifestations of HCV-infection During and After Treatment With OBV/PTV/r and DSV
Status: TERMINATED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: OBV/PTV/r and DSV|DRUG: Placebo to match OBV/PTV/r and DSV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Application of Deuterated Water (D2O) to Define the Etiology of Musculoskeletal Decline in Ageing and the Efficacy of Nutritional Supplementation
Status: UNKNOWN
Conditions: Healthy
Interventions: BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy Transverse Abdominal Plane (TAP) Block Renal Transplant Surgery
Status: UNKNOWN
Conditions: Renal Insufficiency, Chronic|Acute Pain|Kidney Transplantation|Anesthesia, Conduction
Interventions: PROCEDURE: TAP Block|PROCEDURE: Saline Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Dose Study Investigating the Safety, Tolerability, and PK of XC130-A10H in Healthy Adult Subjects
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: DRUG: XC130-A10H|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Healthy Parents - Healthy Children. Weight Loss Before Fertility Treatment
Status: COMPLETED
Conditions: Infertility|Overweight and Obesity|Weight Loss|Vaginal Flora Imbalance|DNA Damage
Interventions: BEHAVIORAL: Systematic weight loss intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Gait Rehabilitation for Veterans With Non-traumatic Lower Limb Amputation
Status: RECRUITING
Conditions: Transtibial Amputation|Peripheral Artery Disease|Diabetes Mellitus
Interventions: BEHAVIORAL: Error-augmentation gait training|BEHAVIORAL: Error-correction gait training|BEHAVIORAL: Supervised walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 22 G - 25 G SINS Trial for Pancreatic Masses
Status: COMPLETED
Conditions: Pancreatic Neoplasms
Interventions: PROCEDURE: EUS-FNA of pancreatic masses|DEVICE: 22 gauge needle|DEVICE: 25 gauge needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Timing of Revascularization in Patients With Diabetic Foot Ulcer and Non-critical Peripheral Artery Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetic Foot Ulcer
Interventions: PROCEDURE: Revascularization|PROCEDURE: Standard wound care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inflammation and Co-Infections in D²EFT
Status: WITHDRAWN
Conditions: HIV-infection/Aids|Human Herpesvirus 4 Infections|Cytomegalovirus Infections|Human Herpesvirus 8 Infection|Human Papilloma Virus
Interventions: DRUG: NRTIs|DRUG: Darunavir|DRUG: Ritonavir|DRUG: Dolutegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Prospective, Observational Study On The Effectiveness Of New Antiepileptic Drugs As First Bitherapy In The Daily Clinical Practice
Status: COMPLETED
Conditions: Focal Epilepsy
Interventions: DRUG: Gabapentin, Lamotrigine, Levetiracetam, Pregabalin, Oxcarbacepine, Tiagabine, Topiramate, Zonisamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Superiority of Intelligent Video Surveillance + Telealarm Over Telealarm Alone in Elderly People at Risk of Falling
Status: RECRUITING
Conditions: Intelligent Video Surveillance|Fall|Home|Frail Elderly Person
Interventions: OTHER: video system|OTHER: Tele-alarm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Novel Types 1 and 3 Oral Poliomyelitis Vaccines
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: Novel Oral Polio Vaccine Type 1 (nOPV1)|BIOLOGICAL: Novel Oral Polio Vaccine Type 3 (nOPV3)|BIOLOGICAL: Sabin Monovalent Oral Polio Vaccine Type 1 (mOPV1)|BIOLOGICAL: Sabin Monovalent Oral Polio Vaccine Type 3 (mOPV3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Ibrutinib Followed by Ibrutinib in Combination With Nivolumab in Non-Small Cell Lung Cancer (NSCLC)
Status: WITHDRAWN
Conditions: Lung Cancer, Nonsmall Cell, Stage I
Interventions: DRUG: Ibrutinib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About PF-07921585 Alone or With Other Anti-cancer Medicines in People With Cancer
Status: NOT_YET_RECRUITING
Conditions: Non Small Cell Lung Cancer|Bladder Cancer|Renal Cell Carcinoma|Melanoma|Head and Neck Cancer|Colorectal Cancer
Interventions: BIOLOGICAL: PF-07921585|BIOLOGICAL: Sasanlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of the Safety and Comfort of AC-170
Status: COMPLETED
Conditions: Normal Ocular Health
Interventions: DRUG: AC-170 0.17%|DRUG: AC-170 0.24% (Formulation 1)|DRUG: AC-170 0.24% (Formulation 2)|DRUG: Olopatadine hydrochloride 0.2%/Tears Naturale II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pediatric and Young Adult Trial of Genetically Modified T Cells Directed Against CD22 for Relapsed/Refractory Leukemia or Lymphoma
Status: RECRUITING
Conditions: Leukemia|Lymphoma
Interventions: BIOLOGICAL: SCRI-CAR22v2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: WATCHMAN for Concomitant Left Atrial Appendage Electrical Isolation and Occlusion to Treat Persistent Atrial Fibrillation Rhythm
Status: WITHDRAWN
Conditions: Persistent Atrial Fibrillation
Interventions: DEVICE: Pulmonary Vein Isolation|DEVICE: LAA Isolation|DEVICE: LAA Occlusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenetic Panel to Prevent Adverse Drug Reactions in Daily Primary Care Practice:
Status: NOT_YET_RECRUITING
Conditions: Pharmacogenomic Drug Interaction|Side Effect of Drug|Ineffective Drug Action|Drug Metabolism, Poor, CYP2D6-Related|Drug Metabolism, Poor, CYP2C19-Related
Interventions: DIAGNOSTIC_TEST: PGx panel test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RT
Status: COMPLETED
Conditions: Central Nervous System Tumor, Pediatric
Interventions: BIOLOGICAL: filgrastim|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: dexrazoxane hydrochloride|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: leucovorin calcium|DRUG: methotrexate|DRUG: temozolomide|DRUG: therapeutic hydrocortisone|DRUG: vincristine sulfate|RADIATION: radiation therapy|DRUG: Dactinomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicentric Trial Comparing Three Therapeutical Strategies in Patients With Acute Primary HIV Infection
Status: TERMINATED
Conditions: HIV Infections|Primary Acute Infection
Interventions: DRUG: Antiretroviral combination (drugs)|DRUG: Pegylated Interferon alpha (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hepatic Arterial Infusion Oxaliplatin, Capecitabine With or Without Bevacizumab
Status: COMPLETED
Conditions: Advanced Cancers
Interventions: DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Potential Effects of a Single-Dose Administration of Trabectedin on the QT Intervals of the Electrocardiogram
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: Trabectedin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intravascular Ultrasound-Guided PCI in Patients With Chronic Kidney Disease
Status: RECRUITING
Conditions: Coronary Artery Disease|Chronic Kidney Diseases
Interventions: PROCEDURE: Percutaneous coronary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Transcranial Direct Current Stimulation (tDCS) in Gambling Disorder
Status: UNKNOWN
Conditions: Pathological Gambling
Interventions: DEVICE: Transcranial direct current stimulation (tDCS)|BEHAVIORAL: Cognitive Behavioural Therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Electrical Stimulation for Continence After Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injury|Neurogenic Bladder|Incontinence
Interventions: DEVICE: Finetech Vocare Bladder System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Relative Bioavailability of Gilteritinib Following a Single Dose of Gilteritinib Mini-tablet Oral Suspension and Gilteritinib Mini-tablets Compared to a Single Dose of Gilteritinib Tablet in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: gilteritinib|DRUG: gilteritinib mini tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Target-controlled Infusion Anesthesia and Post-induction Hypotension
Status: COMPLETED
Conditions: General Anesthesia|Hemodynamic Instability
Interventions: OTHER: Manual anesthesia induction|OTHER: Anesthesia induction with Target controlled infusions (TCI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: 9-ING-41 Plus Carboplatin in Patients With Advanced, Metastatic Salivary Gland Carcinoma
Status: WITHDRAWN
Conditions: Salivary Gland Carcinoma|Adenoid Cystic Carcinoma|Salivary Gland Cancer|Salivary Gland Neoplasms
Interventions: DRUG: 9-ING-41|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peripheral Perfusion and Oxygenation in Areas of Risk of Skin Integrity Impairment Exposed to Pressure Patterns.
Status: UNKNOWN
Conditions: Pressure Ulcer
Interventions: DEVICE: tcpO2|DEVICE: Laser Doppler
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bevacizumab Given With Either Anastrozole or Fulvestrant With Trastuzumab for Postmenopausal Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Breast Neoplasms
Interventions: DRUG: Bevacizumab|DRUG: Anastrozole|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficiency of PRP on Acellular Dermal Matrix Application in the Treatment of Multiple Adjacent Gingival Recessions
Status: COMPLETED
Conditions: Gingival Recession, Generalized
Interventions: PROCEDURE: CAF+ADM+PRP|PROCEDURE: CAF+ADM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Luteal Phase Support During Frozen Embryo Transfer Cycle
Status: COMPLETED
Conditions: Infertility, Female|Frozen Embryo Transfer
Interventions: DRUG: Strogen|DRUG: Strogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Conventional Dose Regimen and New Dose Regimen of Pregabalin
Status: TERMINATED
Conditions: Pain, Neuropathic
Interventions: DRUG: Pregabalin 75mg bid|DRUG: Pregabalin 25mg, 50mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Longterm HPN With Two Lipid Emulsions
Status: COMPLETED
Conditions: Malnutrition
Interventions: DRUG: Lipoplus|DRUG: Lipofundin MCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of a Mindfulness-Based Intervention Delivered Via Instant Messaging on Parents' Wellbeing: A Randomized Controlled Trial and Investigation of Moderators
Status: UNKNOWN
Conditions: Parents|Stress
Interventions: BEHAVIORAL: Mindfulness training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of VOXX/eSmartr High Performance Technology on Sports Vision Ability
Status: COMPLETED
Conditions: Vision, Binocular|Sports Medicine
Interventions: OTHER: Voxx socks and sleeves
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Optimal Hypertension Regimens
Status: UNKNOWN
Conditions: Hypertension
Interventions: DRUG: Amlodipine|DRUG: Lisinopril|DRUG: Amiloride|DRUG: Chlortalidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Timing of Inguinal Hernia Repair in Premature Infants
Status: COMPLETED
Conditions: Inguinal Hernia|Premature Birth of Newborn
Interventions: PROCEDURE: IH repair before NICU discharge|PROCEDURE: IH repair at 55-60 weeks post-menstrual age
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation as a Neuroprotection in Acute Stroke
Status: COMPLETED
Conditions: Stroke, Acute
Interventions: DEVICE: Transcranial Direct Current Stimulation|OTHER: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Expanded Access Protocol to Provide Patisiran to Patients With Transthyretin-mediated Amyloidosis With Cardiomyopathy
Status: NO_LONGER_AVAILABLE
Conditions: Transthyretin-mediated Amyloidosis With Cardiomyopathy|ATTR Amyloidosis With Cardiomyopathy
Interventions: DRUG: Patisiran
Study Type: EXPANDED_ACCESS
Clinical trial: Phase III Study of Florbetaben (BAY94-9172) PET Imaging for Detection/Exclusion of Cerebral β-amyloid Compared to Histopathology
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Florbetaben (BAY94-9172)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: STUDY THAT COMPARE 3 ARM: MLN9708 DEXAMETHASONE, MLN9708 CYCLOPHOSPHAMIDE AND DEXAMETHASONE, MLN9708 THALIDOMIDE AND DEXAMETHASONE FOLLOWED BY MAINTENANCE WITH MLN9708 IN NEWLY DIAGNOSED ELDERLY MULTIPLE MYELOMA PATIENTS
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: MLN9708|DRUG: Dexamethasone|DRUG: Cyclophosphamide|DRUG: Thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lens Wearing Experience and Biocompatibility of a Marketed Multi-Purpose Disinfecting Solution in Silicone Hydrogel and Soft Contact Lens Wearers
Status: COMPLETED
Conditions: Refractive Error
Interventions: DEVICE: OPTI-FREE PureMoist
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A New Protocol for the Management of Dental Erosion in Rugby Players
Status: COMPLETED
Conditions: Dental Erosion
Interventions: OTHER: SRP + toothpaste + mouthwash|OTHER: SRP + toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interaction Between NGF and Acute Exercise-induced Ischemia
Status: COMPLETED
Conditions: Hyperalgesia|Pain Response|Healthy Subjects
Interventions: DRUG: NGF|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Optimizing Neoadjuvant Regimens in Subtypes of Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer|Neoadjuvant Chemotherapy
Interventions: DRUG: Paclitaxel and carboplatin|DRUG: Paclitaxel|DRUG: Epirubicin and Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conectar Jugando Online: Board Games to Improve Executive Function in School-age Children (CJ-Online)
Status: COMPLETED
Conditions: Cognitive Change|Child Development
Interventions: BEHAVIORAL: Conectar Jugando Online Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nasal Expiratory Resistance in Patients With Sleep Apnea and Expiratory Flow Limitation
Status: TERMINATED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Expiratory resistance|DEVICE: Sham expiratory resistance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Simethicone on Eustachian Tube Dysfunction
Status: COMPLETED
Conditions: Otitis Media
Interventions: DRUG: Simethicone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Added Sugar Intake on Cerebrovascular Function and Brain Integrity
Status: COMPLETED
Conditions: Healthy Diet|Healthy Aging
Interventions: OTHER: Low Added Sugar Meal|OTHER: High Added Sugar Meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Pharmacokinetics of Double Boosted Protease Inhibitors in Antiretroviral-naive HIV-1 Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Saquinavir, lopinavir, ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation for People With COVID-19 in ICU
Status: COMPLETED
Conditions: Corona Virus Disease 19 (COVID-19)|COVID|Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)|Critical Illness
Interventions: OTHER: Pulmonary and Motor Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of SARS-CoV-2 Nanoparticle Vaccine (GBP510) Adjuvanted With Aluminum Hydroxide (COVID-19)
Status: COMPLETED
Conditions: COVID-19 (Healthy Volunteers)
Interventions: BIOLOGICAL: GBP510 adjuvanted with Alum (RBD 10μg/dose) - Stage 1|OTHER: Normal saline (0.9% sodium chloride solution) - Stage 1|BIOLOGICAL: GBP510 adjuvanted with Alum (RBD 25μg/dose) - Stage 1|OTHER: Normal saline (0.9% sodium chloride solution) - Stage 1|BIOLOGICAL: GBP510 adjuvanted with Alum (RBD 10μg/dose) - Stage 2|BIOLOGICAL: GBP510 adjuvanted with Alum (RBD 25μg/dose)- Stage 2|OTHER: Normal saline (0.9% sodium chloride solution)- Stage 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Celecoxib for Reducing Morphine Requirement After Thyroid Surgery: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Postoperative Pain|Thyroidectomy|Cyclooxygenase 2 Inhibitors
Interventions: DRUG: celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on New Strategies for Hepatitis B Virus Immunization
Status: COMPLETED
Conditions: Vaccine Reaction
Interventions: BIOLOGICAL: 20μg Engerix-B hepatitis B vaccine|BIOLOGICAL: 20μg Kangtai hepatitis B vaccine|BIOLOGICAL: 60μg Kangtai hepatitis B vaccine|BIOLOGICAL: 20μg CHO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 2/3 Study of TVP-1012 at 0.5 mg or 1 mg in Levodopa Treated Parkinson's Disease Participants
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: TVP-1012 1mg|DRUG: TVP-1012 0.5mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Chronic Kidney Disease (CKD) and Risk Factors in Sub-Saharan Africa
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Diabetes Mellitus|Hypertension|Tuberculosis|Schistosomiasis|HIV Infections
Interventions: DIAGNOSTIC_TEST: estimated glomerular filtration rate and albuminuria
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dairy Modulation of Oxidative and Inflammatory Stress in Overweight and Obese Subjects
Status: COMPLETED
Conditions: Obesity|Overweight
Interventions: DIETARY_SUPPLEMENT: Milk|DIETARY_SUPPLEMENT: Soy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Influenza Vaccination of Healthcare Workers (HCW) on the Risk of Influenza in Patients Hospitalized in Short Stays Units
Status: COMPLETED
Conditions: Patient With Influenza Like Illness
Interventions: BIOLOGICAL: A nasal swab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Transtheoretical Model Based Nursing Interventions on Smoking Cessation in Patients With COPD
Status: COMPLETED
Conditions: COPD|Smoking Cessation|Home Visit
Interventions: OTHER: Assigned Interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of Tumor Antigen-Pulsed Autologous Dendritic Cell Vaccination Administrated Subcutaneously or Intranodally
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Dexamethasone|DRUG: Thalidomide|DRUG: Cisplatinum|DRUG: Adriamycin|DRUG: Cyclophosphamide|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Tabalumab (LY2127399) in Japanese Participants With Relapsed or Refactory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: Tabalumab|DRUG: Bortezomib IV|DRUG: Bortezomib SC|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Enchanting Symphony of Haptonomy's Impact on Attachment and Spousal Harmony for Women Conceiving Through Infertility Treatment
Status: ENROLLING_BY_INVITATION
Conditions: Infertility
Interventions: BEHAVIORAL: haptonomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Routine Health Care of Patients With FSHD
Status: RECRUITING
Conditions: Primary Disease Fascioscapulohumeral Dystrophy (FSHD)
Interventions: OTHER: Followed with an initial assessment, six months and followed annually for 3 years corresponding to the usual follow-up of the patient.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of CKDB-501A in Subjects With Moderate-to-severe Glabellar Lines
Status: COMPLETED
Conditions: Glabellar Lines
Interventions: DRUG: CKDB-501A|DRUG: Botox®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Self-administration of AOP2014 Using a Pen, Developed for the Treatment of Polycythemia Vera Patients
Status: COMPLETED
Conditions: Polycythemia Vera
Interventions: DRUG: Pegylated-Proline-Interferon alpha-2b in a Pre-filled Pen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Food on the Oral Bioavailability of Relacorilant in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Relacorilant under fasted conditions|DRUG: Relacorilant after a high-fat meal|DRUG: Relacorilant after a low-fat meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Mifepristone and Mid-Trimester Termination of Pregnancy
Status: COMPLETED
Conditions: Abortion, Induced|Abortion, Second Trimester
Interventions: DRUG: Addition of mifepristone 200 mg 24 hours before induction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Performance-based Reinforcement to Enhance Cognitive Remediation Therapy
Status: COMPLETED
Conditions: Substance-Related Disorders|Mental Disorders
Interventions: BEHAVIORAL: Cognitive Remediation Therapy - Standard|BEHAVIORAL: Cognitive Remediation Therapy plus Contingency Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prediction of Drug Interactions With CYP2C9 Substrates
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Phenytoin|DRUG: Rifampicin|DRUG: Diclophenac|DRUG: Fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose:
Clinical trial: The Efficacy and Safety of Secukinumab in Patients With Ichthyoses
Status: COMPLETED
Conditions: Ichthyosis|Autosomal Recessive Congenital Ichthyosis|Lamellar Ichthyosis|Congenital Ichthyosiform Erythroderma|Epidermolytic Ichthyosis|Netherton Syndrome
Interventions: DRUG: Secukinumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Hypnosis Via Virtual Reality During Oocyte Retrieval
Status: COMPLETED
Conditions: Virtual Reality Therapy|Fertilization in Vitro|Propofol|Remifentanil|Conscious Sedation
Interventions: DEVICE: Virtual reality distraction|DRUG: Propofol-remifentanil sedation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of SB 11285 Alone and in Combination With Atezolizumab in Patients With Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma|Head and Neck Squamous Cell Carcinoma|Solid Tumor
Interventions: DRUG: SB 11285|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Cognitive and Emotional Disorders in Amyotrophic Lateral Sclerosis
Status: UNKNOWN
Conditions: Amyotrophic Lateral Sclerosis
Interventions: OTHER: MRI + 18FDG-PET + neuropsychological assessments ; 18FDG performed especially for the research
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: To Evaluate the Safety and Performance of the AMS ActivHeal Silicone Foam and the ActivHeal Silicone Foam Lite Dressing.
Status: COMPLETED
Conditions: Wound
Interventions: OTHER: Assigned interventions.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beef in an Optimal Lean Diet (BOLD) Effects on Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome|Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: BOLD Diet|DIETARY_SUPPLEMENT: BOLD-X Diet|DIETARY_SUPPLEMENT: Modified DASH Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of SARS-COV-2 (COVID-19), Influenza and RSV 8-Well MT-PCR Panel for In Vitro Diagnostics
Status: NOT_YET_RECRUITING
Conditions: Respiratory Viral Infection
Interventions: DIAGNOSTIC_TEST: SARS-COV-2, Influenza and RSV 8-Well MT-PCR Panel|DIAGNOSTIC_TEST: BioFire Respiratory Panel 2.1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC