pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Daratumumab Based Response Adapted Therapy for Older Adults With Newly Diagnosed Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Daratumumab Injection|DRUG: Dexamethasone Oral|DRUG: Lenalidomide Pill|DRUG: Bortezomib Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Ultrasound-guided Transversus Abdominis Plane Block in Open Aortic Abdominal Aneurysm Repair Surgery
Status: UNKNOWN
Conditions: Aortic Aneurysm, Abdominal|Pain|Anesthesia, Local
Interventions: PROCEDURE: TAP block|DRUG: PCA with Chlorhydrate of Morphine|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post Spinal Anesthesia Hypotension and Preoperative Hydration
Status: UNKNOWN
Conditions: Anesthesia, Spinal|Cesarean Section
Interventions: DIETARY_SUPPLEMENT: Nutricia PreOp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety Assessment of Lyxumia (Lixisenatide) and Sulfonylurea as Add-on Treatment to Basal Insulin in Uncontrolled Patients With Type 2 Diabetes Mellitus Who Elect to Fast During Ramadan
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Lixisenatide (AVE0010)|DRUG: Sulfonylurea|DRUG: metformin|DRUG: basal insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thoracic Paravertebral Block Versus Rhomboid Block for Postoperative Pain Control in Thoracic Surgeries
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Thoracic Paravertebral Block|PROCEDURE: Rhomboid Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Insecure Attachment and Psychosocial Functioning in Autistic Adults Are Mediated by Depression and Paranoid Ideation
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Insecure attachment and psychosocial functioning in autistic adults
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: To Compare Brolucizumab to Aflibercept in Chinese Patients With Visual Impairment Due to Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Brolucizumab|DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mesalamine 4 g Sachet for the Induction of Remission in Active, Mild to Moderate Ulcerative Colitis (UC)
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Mesalamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing a Meditation App With Justice-Involved Youth on Probation
Status: RECRUITING
Conditions: Emotion Regulation|Alcohol Use|Cannabis Use|Sexual Behavior|Aggression
Interventions: BEHAVIORAL: Bodhi AIM (intervention group)|BEHAVIORAL: HIB (control group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Resilience and Equity in Aging, Cancer, and Health (REACH)
Status: RECRUITING
Conditions: Gastric Cancer|Colon Cancer|Esophageal Cancer|Rectal Cancer|Pancreatic Cancer|Gastrointestinal Cancer
Interventions: OTHER: Phase 2 Intervention - Geriatric Co-Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Reinducing Radioiodine-sensitivity in Radioiodine-refractory DTC Using Lenvatinib (RESET)
Status: RECRUITING
Conditions: Differentiated Thyroid Cancer
Interventions: RADIATION: rhTSH-stimulated I-124 dosimetry|RADIATION: Intra-therapeutic I-131 dosimetry
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post Transplant Cyclophosphamide (PTCY) as Sole Graft Versus Host Disease (GVHD) Prophylaxis for Matched Allotransplant: CYRIC
Status: TERMINATED
Conditions: Graft Versus Host Disease
Interventions: DRUG: Fludarabine|DRUG: Clofarabine|RADIATION: Full body irradiation|DRUG: Cyclophosphamide|DRUG: Cyclophosphamide|OTHER: stem cell transplantation|OTHER: nuclear cells|DRUG: Thymoglobulin Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine Effect of Gentle Wounding to Stimulate Hair Follicle Neogenesis
Status: ENROLLING_BY_INVITATION
Conditions: Central Centrifugal Cicatricial Alopecia (CCCA)
Interventions: DRUG: Retinoic acid|DEVICE: Laser|DRUG: Sham treatment|DEVICE: Sham treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics of Subcutaneous AZD6912 in Healthy Participants
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: AZD6912|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Avastin in Patients Treated in a Previous Genentech-Sponsored Cancer Study
Status: COMPLETED
Conditions: Breast Cancer|Colorectal Cancer|Metastases
Interventions: DRUG: Avastin (bevacizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability of Dabigatran Capsules, Pellets and Oral Solution in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Dabigatran etexilate|DRUG: Dabigatran etexilate|DRUG: Dabigatran etexilate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study of a Novel Peri Infusion Regimen on the Infusion Associated Reactions With Alemtuzumab Infusion in Patients With Multiple Sclerosis in a Canadian Clinical Setting.
Status: COMPLETED
Conditions: Frequency of Infusion Reactions in Novel Versus Standard Protocol in Multiple Sclerosis
Interventions: DRUG: Alemtuzumab Injection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prevention and Risk: Treatment With a New Emphasis on Relationships
Status: COMPLETED
Conditions: Adherence, Medication|Risk Reduction|Drug Use|Sex, Anal|HIV/AIDS
Interventions: BEHAVIORAL: PARTNER|BEHAVIORAL: Education Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacologic Treatment of PTSD in Sexually Abused Children
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic
Interventions: BEHAVIORAL: Trauma-Focused Cognitive Behavioral Therapy|DRUG: Sertraline Pill|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NoNO-42 Trial in Acute Ischemic Stroke Patients Selected for Thrombolysis With or Without Endovascular Thrombectomy
Status: NOT_YET_RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DRUG: NoNO-42|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Safety and Tolerability Study of Staphylococcal Protein A in Adult Patients With Chronic ITP
Status: TERMINATED
Conditions: Idiopathic Thrombocytopenic Purpura (ITP)
Interventions: DRUG: PRTX-100 (Staphylococcal protein A)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Disulfiram: A Test of Symptom Reduction Among Patients With Previously Treated Lyme Disease
Status: COMPLETED
Conditions: Fatigue|Quality of Life
Interventions: DRUG: Disulfiram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nanodisk-MS Assay for the Diagnosis of Active Pulmonary and Extrapulmonary Tuberculosis in Hospitalized Patients
Status: COMPLETED
Conditions: Active Tuberculosis|Tuberculosis, Extrapulmonary|Tuberculosis, Pulmonary
Interventions: DIAGNOSTIC_TEST: Nanodisk-MS assay
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reliability and Validity of the MINI International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)
Status: COMPLETED
Conditions: Major Depression|Mania|Anxiety Disorders|Psychotic Disorder|Alcohol Dependence|Drug Dependence|Eating Disorders|Suicidality|Dysthymia|ADHD|Tourettes Disorder|Conduct Disorder|Oppositional Defiant Disorder|Pervasive Developmental Disorder
Interventions: OTHER: MINI-KID
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy Study of WeFlow-JAAA Stent Graft System for Complex Abdominal Aortic Aneurysm(GREAT Study)
Status: UNKNOWN
Conditions: Juxtarenal Abdominal Aortic Aneurysm
Interventions: DEVICE: WeFlow-JAAA Stent Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CCI-779 and Rituximab in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Recurrent Mantle Cell Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Aastrom Tissue Repair Cells to Treat Non-Union Fractures.
Status: TERMINATED
Conditions: Fracture, Ununited|Pseudarthrosis
Interventions: PROCEDURE: Fracture surgery|DRUG: Cultured Bone Marrow Tissue
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STI 571 (GLIVEC) in the Treatment of Adult Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurobehavioral Affective Control Training
Status: NOT_YET_RECRUITING
Conditions: Emotional Distress|Impulsive Behavior|Mood Lability|Mood Instability|Rumination|Psychopathology|Affective Symptoms
Interventions: BEHAVIORAL: Neurobehavioral Affective Control Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lateral Cutaneous Nerve and PENG Blocks Versus Suprainguinal Fascia Iliaca Block in Post-op Analgesia of Hip Fractures
Status: NOT_YET_RECRUITING
Conditions: Anesthesia, Conduction
Interventions: DRUG: Ropivacaine + saline solution|DRUG: Saline solution + Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AMBU AScope2 Fiberoptic Intubation Versus Fastrach Intubating LMA
Status: COMPLETED
Conditions: Supraglottic Airway
Interventions: DEVICE: AMBU Aura-I/aScope 2|DEVICE: LMA Fastrach Single Use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Molecular-Guided Therapy for Relapsed and Refractory Childhood Cancer
Status: COMPLETED
Conditions: Neuroblastoma|Medulloblastoma|Brain Tumors|Rare Tumors
Interventions: DEVICE: Guided Therapy- Pediatric Gene Analysis Platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Membrane Oxygenation Physical Training
Status: COMPLETED
Conditions: Critically Ill, Mechanically Ventilated|Extracorporeal Membrane Oxygenation Complication
Interventions: BEHAVIORAL: Early activity and Mobilisation intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nurse-led Placement of Peripheral Venous Catheters in Overweight Patients Using Standard or Dynamic Ultrasound-guided Technique
Status: COMPLETED
Conditions: Overweight and Obesity|Emergencies
Interventions: DEVICE: Dynamic ultrasound-guided short-axis needle tip navigation|OTHER: Standard technique of placing a PVC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Biomechanical-based Tai Chi Program on Gait and Posture in People With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: Tai Chi intervention|OTHER: Regular Physical Activity (control) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial Comparing Torcetrapib/Atorvastatin to Ezetimibe/Simvastatin In Subjects With A Cholesterol Disorder.
Status: TERMINATED
Conditions: Hyperlipidemia|Dyslipidemia
Interventions: DRUG: torcetrapib/atorvastatin|DRUG: ezetimibe/simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Evaluate The Efficacy of Adapalene 0.3% for Use in the Prevention and Treatment of Senile Purpura
Status: UNKNOWN
Conditions: Senile Purpura
Interventions: DRUG: adapalene gel 0.3%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Establishing a Sonographic Based Algorithm to Verify Pancreatic Stent Position Placed to Prevent Post-ERCP Pancreatitis Before Endoscopic Removal
Status: COMPLETED
Conditions: Post-ERCP Acute Pancreatitis|Pancreatic Stent|Ultrasound|X-rays
Interventions: DIAGNOSTIC_TEST: Sonographic based visualization of a pancreatic stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dexamethasone Study: Impact on Quality of Life of Continuing Dexamethasone Following Emetogenic Chemotherapy
Status: COMPLETED
Conditions: Cancer|Emesis|Nausea
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effectiveness and Safety of Multiple Applications of Imiquimod 5% Cream for the Treatment of Actinic Keratoses in Organ Transplant Recipients
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Imiquimod 5 % Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Atezolizumab in Participants With Locally Advanced or Metastatic Urothelial Bladder Cancer (Cohort 1)
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Observational Exploratory Clinical Study to Determine the Assay Cut-Off for the RadTox Test in Prostate Cancer Patients to Predict Gastrointestinal Radiation Toxicity Using Circulating Cell Free DNA Directly From Plasma
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: OTHER: Collection of plasma samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Thiol Disulfide Balance in Stage 1 Endometrium Cancer
Status: COMPLETED
Conditions: Endometrium Cancer|Oxidative Stress
Interventions: DIAGNOSTIC_TEST: Disulphide(μmol/L)|DIAGNOSTIC_TEST: Total Oxidant Capacity(μmolH2O2Equiv/L)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Men
Status: RECRUITING
Conditions: Transgender|Gender Identity|Vascular Stiffness|Vascular Inflammation|Blood Pressure|Lipid Disorder|Appetitive Behavior
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Irinotecan Plus Raltitrexed as Second-line Treatment in Advanced Colorectal Cancer Patients
Status: UNKNOWN
Conditions: ColoRectal Cancer
Interventions: DRUG: Irinotecan|DRUG: Raltitrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Vitamin B12 Supplementation and Cognitive Performance in Elderly People
Status: COMPLETED
Conditions: Cognitive Decline|Cognitive Symptoms
Interventions: BEHAVIORAL: vitamin B12 supplementation|BEHAVIORAL: vitamin B12 + folic acid combined supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Safety and Effectiveness of MRgFUS Compared With Myomectomy for the Treatment of Uterine Fibroids
Status: WITHDRAWN
Conditions: Uterine Fibroids|Bleeding|Pelvic Pain
Interventions: DEVICE: Exablate 2100|PROCEDURE: Myomectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Acute Hypercapnic Respiratory Failure With OptiflowTM or Optiflow+DuetTM Nasal Cannula in COPD-patients
Status: NOT_YET_RECRUITING
Conditions: Hypercapnic Respiratory Failure|COPD
Interventions: OTHER: Respiratory Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incontinence and Quality of Life in Children With Spina Bifida
Status: RECRUITING
Conditions: Spina Bifida|Myelomeningocele
Interventions: BEHAVIORAL: Phase One: Exploration|BEHAVIORAL: Phase Two: Creation|BEHAVIORAL: Phase Three: Reflection|BEHAVIORAL: Aim 3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Er,Cr:YSGG Laser Application in Peri-implantitis
Status: COMPLETED
Conditions: Peri-Implantitis
Interventions: DEVICE: Er, Cr: YSGG laser-assisted non-surgical mechanical therapy|DEVICE: Non-surgical mechanical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Bioequivalence Study Comparing Nicergoline 10 mg Tablet Manufactured in China With Nicergoline 10 mg Tablet Manufactured in Italy Under Fasted and Fed Conditions in Healthy Chinese Participants
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Nicergoline from China|DRUG: Nicergoline from Italy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Polatuzumab Vedotin (DCDS4501A) in Combination With Rituximab or Obinutuzumab Plus Bendamustine in Participants With Relapsed or Refractory Follicular or Diffuse Large B-Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Bendamustine|DRUG: Obinutuzumab|DRUG: Polatuzumab vedotin (Liquid)|DRUG: Rituximab|DRUG: Polatuzumab vedotin (Lyophilized)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of SARS-CoV-2 mRNA Vaccine in Chinese People
Status: COMPLETED
Conditions: SARS-CoV-2
Interventions: BIOLOGICAL: SARS-CoV-2 (LVRNA009) 50μg group|BIOLOGICAL: SARS-CoV-2 (LVRNA009) 100μg group|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: French Evaluation Group Avastin Versus Lucentis
Status: COMPLETED
Conditions: Age Related Macular Degeneration
Interventions: DRUG: Avastin|DRUG: Lucentis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: Induction Chemotherapy|DRUG: Low-Risk Therapy|DRUG: High-Risk Therapy|DRUG: Intermediate-Risk Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Determine the Efficacy and Safety of DW1029M on Microalbuminuria in Patients With Diabetic Nephropathy
Status: COMPLETED
Conditions: Diabetic Nephropathy
Interventions: DRUG: DW1029M 600mg|DRUG: DW1029M 1200mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of AMA1-C1/Alhydrogel® (Registered Trademark) + CPG 7909 Malaria Vaccine
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: AMA1-C1/Alhydrogel + CPG 7909 (Saline)|BIOLOGICAL: AMA1-C1/Alhydrogel + CPG 7909 (Phosphate)|DRUG: AMA1-C1/Alhydrogel + CPG 7909
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Mirror Trial - Follow-Up Management of Peripheral Arterial Intervention With Clopidogrel
Status: COMPLETED
Conditions: Peripheral Vascular Diseases
Interventions: DRUG: clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Safety and Efficacy of Pimavanserin (ACP-103) in Patients With Parkinson's Disease Psychosis
Status: COMPLETED
Conditions: Parkinson's Disease Psychosis
Interventions: DRUG: Pimavanserin tartrate (ACP-103)|DRUG: Pimavanserin tartrate (ACP-103)|DRUG: Pimavanserin tartrate (ACP-103)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First Research Study to Compare a Possible New Medicine NNC9204-1513 to the Medicine Glucagon, in Healthy People.
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DRUG: NNC9204-1513|DRUG: Glucagon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Benefit of SAR650984, Bortezomib, Lenalidomide and Dexamethasone Combination in NDMM Patients Not Eligible for Transplant
Status: ACTIVE_NOT_RECRUITING
Conditions: Plasma Cell Myeloma
Interventions: DRUG: Isatuximab SAR650984|DRUG: Bortezomib|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Scalp Nerve Block and Opioid Consumption in Brain Surgery
Status: COMPLETED
Conditions: Brain Tumour
Interventions: DRUG: Scalp block with 0.5% plain Marcaine|DRUG: Scalp block with 0.9% normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brain Ultrasound With Contrast Microbubbles Injection in Shock Status
Status: UNKNOWN
Conditions: Shock|Microcirculation
Interventions: DIAGNOSTIC_TEST: Sulphur hexafluoride microbubbles SONOVUE (BRACCO, Milan, Italy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Potential Role Of MicroRNA-155 And Telomerase Reverse Transcriptase In Diagnosis Of Non-Muscle Invasive Bladder Cancer And Their Pathological Correlation
Status: COMPLETED
Conditions: Bladder Cancer|Bladder Disease|Bladder Neoplasm|Micro-RNA
Interventions: DIAGNOSTIC_TEST: MicroRNAs-155|DIAGNOSTIC_TEST: Human telomerase reverse transcriptase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety Study of Ibuprofen Gel Compared to Placebo in the Treatment of Acute Musculoskeletal Pain
Status: UNKNOWN
Conditions: Musculoskeletal Pain|Acute Pain|Stretch|Sprains
Interventions: DRUG: Ibuprofen gel|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spaulding-Harvard Model System: Effects of Transcranial Direct Current Stimulation (tDCS) on Chronic Pain in Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury|Chronic Pain|Neuropathic Pain
Interventions: DEVICE: Transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Skin and Blood Research Samples From Healthy Volunteers and Patients With Hematologic Diseases
Status: TERMINATED
Conditions: Anemia, Sickle Cell
Interventions: PROCEDURE: Skin biopsy|PROCEDURE: Blood draw & sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Drug Coated Balloons vs Plain Balloons for the Management of Dysfunctional Dialysis Fistula
Status: TERMINATED
Conditions: Dysfunctional Dialysis Arteriovenous Fistula
Interventions: DEVICE: Vessel preparation with angioplasty|DEVICE: Plain balloon angioplasty|DEVICE: Drug coated balloon angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Probiotic on Diverticular Symptoms
Status: COMPLETED
Conditions: Diverticular Disease
Interventions: DIETARY_SUPPLEMENT: Probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Potential Protective Role of Venlafaxine Versus Memantine in Paclitaxel Induced Peripheral Neuropathy
Status: UNKNOWN
Conditions: Oncology Pain|Chemotherapy-induced Peripheral Neuropathy
Interventions: DRUG: Venlafaxine|DRUG: Memantine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Randomised Efficacy Study of Two Artemether-Lumefantrine Oral Formulations for the Treatment of Uncomplicated P. Falciparum Malaria
Status: COMPLETED
Conditions: Malaria, Falciparum
Interventions: DRUG: Artemether/lumefantrine tablets|DRUG: Artemether/Lumefantrine suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aquapheresis Efficacy in Outpatients With Decompensated Heart Failure
Status: WITHDRAWN
Conditions: Heart Failure|Congestive Heart Failure|Decompensated Heart Failure
Interventions: DEVICE: Aquapheresis|DRUG: IV Diuretics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electroacupuncture for Heart Protection: Clinical Application in Patients Undergoing Cardiac Bypass Surgery
Status: RECRUITING
Conditions: Coronary Artery Disease|Electro-Acupuncture
Interventions: PROCEDURE: Electro-Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Immunogenicity of Quadrivalent LAIV in Adults 18 to 49 Years of Age
Status: COMPLETED
Conditions: Healthy or Stable Underlying Chronic Medical Condition
Interventions: BIOLOGICAL: Q/LAIV (MEDI3250)|BIOLOGICAL: FluMist/B/Yamagata|BIOLOGICAL: FluMist/B/Victoria
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Topotecan Plus Etoposide in Treating Patients With Recurrent Ovarian, Peritoneal, or Fallopian Tube Cancer
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: etoposide|DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Changes in Clinical Management After DaTSCAN Imaging of Subjects With Clinically Uncertain Parkinsonism or an Illness With Similar Symptoms
Status: COMPLETED
Conditions: Parkinsonian Syndromes
Interventions: PROCEDURE: DaTSCAN SPECT imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment for Foot Pain Caused by Diabetic Neuropathy Using Recurrent TransCutaneous Magnetic Stimulation (TCMS)
Status: UNKNOWN
Conditions: Diabetic Peripheral Neuropathy
Interventions: DEVICE: Transcutaneous Magnetic Stimulation (TCMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: the Effect of Topical Application of Hyaluronic Acid on Immediate Dental Implant
Status: COMPLETED
Conditions: Immediate Dental Implant
Interventions: DEVICE: immediate dental implant|DRUG: Hyaluronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An International Study of Rimonabant in Dyslipidemia With AtheroGenic Risk In Abdominally Obese Patients
Status: COMPLETED
Conditions: Dyslipidemia|Obesity
Interventions: DRUG: Rimonabant (SR141716)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Desensitation Regimen for Patients With High Titers of Anti-HLA Antibodies Prior to Allo-HSCT
Status: NOT_YET_RECRUITING
Conditions: High Titers of Anti-HLA Antibody (MFI ≥5000)
Interventions: COMBINATION_PRODUCT: Immunoadsorption or plasma exchange combined with rituximab, high-dose IVIG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remimazolam Phase II Cardiac Anesthesia Study
Status: COMPLETED
Conditions: General Anesthesia
Interventions: DRUG: Remimazolam|DRUG: Propofol|DRUG: Sevoflurane|DRUG: Remifentanil|DRUG: Fentanyl|DRUG: Rocuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Abnormal Ventilatory Response to Carbon Dioxide: a Potential Biomarker for Seizure Induced Respiratory Depression & Modification by SSRI
Status: COMPLETED
Conditions: Epilepsy|SUDEP
Interventions: DRUG: Fluoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Ventilation With Bag-Valve-Mask, Laryngeal Tube S-D and Laryngeal Mask Airway Supreme
Status: COMPLETED
Conditions: Cardiopulmonary Arrest
Interventions: DEVICE: Bag-Valve-Mask-Ventilation (Ambu Facemask)|DEVICE: Laryngeal Mask (Laryngeal Mask Airway Supreme)|DEVICE: Laryngeal Tube (Laryngeal Tube LT-S-D (VBM))
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of the SGLT2-inhibitor Empagliflozin on Patients With Chronic SIADH - the SANDx Study
Status: COMPLETED
Conditions: SIAD - Syndrome of Inappropriate Antidiuresis|Hyponatremia
Interventions: DRUG: Empagliflozin 25mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Expiratory Muscle Strength Training for Improving Communication in ALS
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DEVICE: Expiratory Muscle Strength Training (EMST-150)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Construction of Computerized Intraoperative Keratometer and Experimental Study
Status: COMPLETED
Conditions: Corneal Astigmatism|Orientation
Interventions: DEVICE: computerized intraoperative keratomer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Safety and Effectiveness of the vPatch Device
Status: COMPLETED
Conditions: Premature Ejaculation
Interventions: DEVICE: Active Device (vPatch)|DEVICE: Sham Device (vPatch)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Strategies to Connect Patients at Federally Qualified Health Clinics With Evidence Based Tobacco Cessation Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Current Smoker|Tobacco Smoking|Tobacco Use
Interventions: OTHER: Electronic Health Record intervention|BEHAVIORAL: Smoking Cessation Intervention|BEHAVIORAL: Telephone-Based Intervention|BEHAVIORAL: Telephone-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: GLS-5310 Vaccine in Healthy Volunteers as a Booster for SARS-CoV-2 (COVID-19)
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19|Healthy
Interventions: DRUG: GLS-5310 (Group 1)|DRUG: GLS-5310 (Group 2)|DRUG: GLS-5310 (Group 3)|DRUG: GLS-5310 (Group 4)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nivolumab After Induction Treatment in Triple-negative Breast Cancer (TNBC) Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Nivolumab|RADIATION: Radiation therapy|DRUG: Low dose doxorubicin|DRUG: Cyclophosphamide|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study of VS-505 in End Stage Renal Disease Patients Undergoing Hemodialysis
Status: UNKNOWN
Conditions: End Stage Renal Disease|Hyperphosphatemia
Interventions: DIETARY_SUPPLEMENT: VS-505
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency
Status: COMPLETED
Conditions: Metabolic Disease|Seizures
Interventions: DRUG: SGS-742|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hypertension In Postpartum Preeclampsia Study
Status: COMPLETED
Conditions: Hypertension, Pregnancy-Induced
Interventions: DRUG: Acetaminophen|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Fimasartan/Amlodipine/Hydrochlorothiazide in Healthy Male Subjects
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Treatment T|DRUG: Treatment R
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ventilatory Investigation of Tirasemtiv and Assessment of Longitudinal Indices After Treatment for a Year
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Tirasemtiv|DRUG: Placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PAEAN - Erythropoietin for Hypoxic Ischaemic Encephalopathy in Newborns
Status: COMPLETED
Conditions: Hypoxic-Ischemic Encephalopathy
Interventions: DRUG: Epoetin Alfa|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Prepackaged Cleansing Cloth and Standardized Cleansing Protocol for Catheter Care at Reducing CAUTI Rates
Status: COMPLETED
Conditions: Catheter-Associated Urinary Tract Infection
Interventions: DEVICE: ReadyCleanse Cloths
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Exercise Prescription Guided by Heart Rate Variability in Breast Cancer Patients
Status: UNKNOWN
Conditions: Breast Cancer|Cardiotoxicity|Autonomic Imbalance
Interventions: OTHER: Physical exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vaccination in the Peripheral Stem Cell Transplant Setting for Acute Myelogenous Leukemia
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia
Interventions: BIOLOGICAL: GVAX leukemia vaccine (therapeutic cellular vaccine, GM-CSF producing)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expanding the Family Check-Up in Early Childhood to Promote Cardiovascular Health of Mothers and Young Children
Status: RECRUITING
Conditions: Obesity, Maternal|Hypertension in Pregnancy|Hypertension, Pregnancy-Induced|Diabetes|Overweight
Interventions: BEHAVIORAL: Family Check Up Heart|BEHAVIORAL: Family Check-Up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Furmonertinib Plus Bevacizumab or Furmonertinib Monotherapy for Resectable and Potentially Resectable Stage III-IVA EGFR Mutation-Positive Lung Adenocarcinoma
Status: RECRUITING
Conditions: Lung Adenocarcinoma Stage III|Lung Adenocarcinoma Stage IV|EGFR Gene Mutation
Interventions: DRUG: Furmonertinib|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Airway Clearance Techniques in Infants.
Status: COMPLETED
Conditions: Gastro-esophageal Reflux
Interventions: OTHER: Assisted Autogenic Drainage (AAD)|OTHER: bouncing and AAD|OTHER: bouncing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of a Multilevel HIV Prevention Intervention for the Emergency Department
Status: NOT_YET_RECRUITING
Conditions: HIV|Drug Use|Mental Health|Psychological Distress|Social Marginalization|Problems With Access to Health Care
Interventions: BEHAVIORAL: mSYNC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Creation of a Normal Database for FluoroDeoxyGlucose-Positron Emission Tomography (FDG-PET) Neurological Examinations
Status: COMPLETED
Conditions: Lymphoma
Interventions: DEVICE: FDG-PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Influence of Dairy Protein Breakfast on Glycemia, Weight Loss and Clock Genes in T2D
Status: UNKNOWN
Conditions: Type2 Diabetes|Healthy Obesity, Metabolically
Interventions: DEVICE: Continuous glucose monitoring CGM|DIAGNOSTIC_TEST: Clock Genes m RNA expression|DIAGNOSTIC_TEST: Postprandial Glucose|DIAGNOSTIC_TEST: Postprandial Insulin|DIAGNOSTIC_TEST: Plasma GLP-1|DIAGNOSTIC_TEST: DPP4 plasma activity|DIAGNOSTIC_TEST: Ghrelin|DIAGNOSTIC_TEST: Plasma CCK|DIAGNOSTIC_TEST: Plasma PYY|OTHER: Body Weight|DIAGNOSTIC_TEST: Blood levels of HbA1c
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Replacement Frequency of Electrodes on Skin in Infant
Status: COMPLETED
Conditions: Infant, Premature
Interventions: PROCEDURE: Replacement every 24 hours|PROCEDURE: Replacement every 12 hours
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Feasibility and Safety Study of Universal Dual Specificity CD19 and CD20 or CD22 CAR-T Cell Immunotherapy for Relapsed or Refractory Leukemia and Lymphoma
Status: UNKNOWN
Conditions: B Cell Leukemia|B Cell Lymphoma
Interventions: BIOLOGICAL: Universal Dual Specificity CD19 and CD20 or CD22 CAR-T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Salvage MR-guided High-Dose-Rate Brachytherapy for Prostate Bed Recurrence After Radiotherapy in the PSMA PET Scan Era
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer Recurrent|Prostate Cancer
Interventions: RADIATION: High Dose Rate Brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Survey of Minimally Invasive Ponto Surgical Technique (MIPS)
Status: COMPLETED
Conditions: Bone Conduction Deafness|Unilateral Deafness|Middle Ear Deafness|Mixed Hearing Loss
Interventions: DEVICE: Minimally Invasive Ponto Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Pneumatic Vitreolysis on Vitreomacular Traction
Status: COMPLETED
Conditions: Vitreomacular Traction
Interventions: DEVICE: Pneumatic Vitreolysis (C3F8 injection)|OTHER: Observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Org 25969 Administered After Zemuron® (MK-8616-042)
Status: COMPLETED
Conditions: Neuromuscular Blockade
Interventions: DRUG: MK-8616|DRUG: Zemuron®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-Test of For the Future Self and Smoking Cessation
Status: WITHDRAWN
Conditions: Adherence, Medication
Interventions: BEHAVIORAL: Future Self Virtual Reality Image - Normal Aging|BEHAVIORAL: Future Self Virtual Reality Image - Smoking Consequences Aging|BEHAVIORAL: Current Self Virtual Reality Image|BEHAVIORAL: Letter - 20 years|BEHAVIORAL: Letter - 3 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Open-angle Glaucoma Subjects on One Topical Hypotensive Medication Randomized to Treatment With One or Two Trabecular Micro-bypass Stents in Conjunction With Cataract Surgery
Status: COMPLETED
Conditions: Open-angle Glaucoma
Interventions: DEVICE: One iStent|DEVICE: Two iStent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ALL-Active: A Family-Based Lifestyle Program for Pediatric Acute Leukemia Patients
Status: COMPLETED
Conditions: Childhood Acute Lymphoblastic Leukemia in Remission
Interventions: DIETARY_SUPPLEMENT: nutritional intervention|BEHAVIORAL: exercise intervention|OTHER: follow-up care|BEHAVIORAL: counseling intervention|OTHER: quality-of-life assessment|OTHER: laboratory biomarker analysis|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of EpiBone-CMF for Mandibular Ramus Reconstruction
Status: UNKNOWN
Conditions: Mandible Tumor|Mandibular Injuries|Mandible; Deformity
Interventions: COMBINATION_PRODUCT: EB-CMF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imaging of Traumatic Brain Injury Metabolism Using Hyperpolarized Carbon-13 Pyruvate
Status: ENROLLING_BY_INVITATION
Conditions: Traumatic Brain Injury
Interventions: DRUG: Hyperpolarized [1-13C] Pyruvate|DRUG: Hyperpolarized [2-13C] Pyruvate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Enoxaparin in the Prevention of Placental Insufficiency in Pregnant Women
Status: COMPLETED
Conditions: Placental Insufficiency|Enoxaparin
Interventions: DRUG: Enoxaparin 40 mg / 0.4 mL Prefilled Syringe|DRUG: Aspirin 100 mg Oral Tablet, Enteric Coated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION