pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of the Molecular Features of Postmenopausal Women With HR+ HER2-negative aBC on First-line Treatment With Ribociclib and Letrozole and, in Patients With a PIK3CA Mutation, on Second-line Treatment With Alpelisib Plus Fulvestrant
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Ribociclib|DRUG: Letrozole|DRUG: Alpelisib|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STop and Restart Acalabrutinib In fRail Patients With Previously Untreated Chronic Lymphocytic Leukemia
Status: RECRUITING
Conditions: Untreated Chronic Lymphocytic Leukemia
Interventions: DRUG: Stop ACA|DRUG: ACA Continuation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immersive Virtual Reality Exergaming Program in Adolescents Diagnosed With Juvenile Idiopathic Arthritis
Status: RECRUITING
Conditions: Juvenile Idiopathic Arthritis
Interventions: BEHAVIORAL: Immersive Virtual Reality Exergaming Program|BEHAVIORAL: Home-Based Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Identifying Sleep Apnea Patients That Best Respond to Atomoxetine Plus Oxybutynin Therapy
Status: RECRUITING
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: Atomoxetine|DRUG: Oxybutynin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of E7386 in Combination With Pembrolizumab in Previously Treated Participants With Selected Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma|Carcinoma, Hepatocellular|Colorectal Neoplasms
Interventions: DRUG: E7386|DRUG: Pembrolizumab|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin in Children With Relapsed or Refractory Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors|Primary Brain Tumors
Interventions: DRUG: Vincristine|DRUG: Irinotecan|DRUG: Temozolomide|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cervical Carious Lesions Restored With Calcium Silicate Based Cement (Biodentine) Compared With Glass-ionomer Cement
Status: COMPLETED
Conditions: Gingivitis
Interventions: DEVICE: GIC|DEVICE: Biodentine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nitrite Infusion in High Risk Patients Undergoing Cardiopulmonary Bypass
Status: WITHDRAWN
Conditions: Acute Kidney Injury
Interventions: DRUG: Saline|DRUG: Sodium Nitrite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pre-operation Chemo and Antibody Therapy Followed by Surgical Resection and Adjuvant Chemoradiation for Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer|Stomach Cancer
Interventions: DRUG: Cetuximab|DRUG: Irinotecan|DRUG: Cisplatin|PROCEDURE: Surgery|DRUG: 5-FU|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hearing Aid Noise Reduction in Pediatric Users Pilot Study (Oticon Pilot Study)
Status: COMPLETED
Conditions: Hearing Impairment|Sensorineural Hearing Loss, Bilateral
Interventions: DEVICE: Oticon OpenSound Navigator speech enhancement algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient Re-education vs. Background Morphine to IV-PCA in Patient With Unsatisfactory Analgesia Post Laparotomy
Status: UNKNOWN
Conditions: Post-operative Pain
Interventions: DRUG: morphine|BEHAVIORAL: Patient re-education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Allergic Rhinitis Patients With Nasal Steroids and NeilMed® Sinus Rinse™ System With Isotonic Saline
Status: COMPLETED
Conditions: Rhinitis
Interventions: DRUG: NeilMed® Sinus Rinse™ System with Isotonic Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-Fluoride Positron Emission Tomography (PET) in Paget's Disease of Bone
Status: COMPLETED
Conditions: Paget's Disease of Bone
Interventions: DRUG: Bisphosphonate treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Relative Bioavailability of OC-01 (Varenicline) Nasal Spray as Compared to Orally Administered Varenicline
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Vaenicline oral tablet 1 mg, then OC-01 (varenicline solution) nasal spray 0.12 mg|DRUG: OC-01 (varenicline solution) nasal spray 0.12 mg then Varenicline oral tablet 1 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dose Response Study of a Natural Extract for Reducing Post Prandial Blood Glucose
Status: COMPLETED
Conditions: Blood Glucose
Interventions: OTHER: Boiled Rice|OTHER: Boiled Rice+0.37 gr mulberry fruit powdered extract|OTHER: Boiled Rice+0.75 gr mulberry fruit powdered extract|OTHER: Boiled Rice+1.12 gr mulberry fruit powdered extract|OTHER: Boiled Rice+1.50 gr mulberry fruit powdered extract|OTHER: Rice Porridge|OTHER: Rice porridge+1.50 gr mulberry fruit powdered extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: rFVIIa Prophylaxis in Children With Hemophilia A and Inhibitors
Status: UNKNOWN
Conditions: Hemophilia A With Inhibitors
Interventions: DRUG: recombinant activated factor VII|DRUG: recombinant activated factor VII
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)
Status: RECRUITING
Conditions: Heart Failure
Interventions: DRUG: Finerenone|DRUG: Empagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine in Children's Interstitial Lung Diseases With Genetic Causes
Status: NOT_YET_RECRUITING
Conditions: Interstitial Lung Disease|Surfactant Dysfunction
Interventions: DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Protective and Worsening Steatohepatitis (NASH) Factors
Status: UNKNOWN
Conditions: Morbid Obesity|Steatohepatitis|Steatosis
Interventions: PROCEDURE: hepatic biopsies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effects of Different Types of Anesthesia on Stress Response in Laparoscopic Gastric Bypass for Type 2 Diabetes Mellitus
Status: UNKNOWN
Conditions: Diabetes|Stress|Anesthesia
Interventions: OTHER: different types of anesthesia|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effectiveness of Auricular Acupuncture on Improving Secretion of Saliva Among Institutional Older Population
Status: COMPLETED
Conditions: Salivary Gland Diseases
Interventions: OTHER: True auricular acupuncture|OTHER: sham auricular acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Probiotics on Streptococcus Mutans ve Lactobacillus Spp
Status: COMPLETED
Conditions: Tooth Decay|Probiotics|Streptococcus Mutans
Interventions: DIETARY_SUPPLEMENT: Probiotic use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bioavailability Study of Amlodipine Besylate/Atorvastatin Calcium Tablets 10/80 mg Under Fasting Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Amlodipine besylate/Atorvastatin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intranasal Midazolam in Children as a Pre-Operative Sedative
Status: COMPLETED
Conditions: Sedation, Conscious
Interventions: DRUG: Midazolam|DRUG: xylocaine|DRUG: saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Adipose-Derived Stem Cell Transplantation in Patients With Lipodystrophy
Status: UNKNOWN
Conditions: Lipodystrophy
Interventions: PROCEDURE: autologous transplantation of liposuction material enriched with adipose-derived stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eculizumab for Prevention of Delayed Graft Function (DGF) in Kidney Transplantation
Status: TERMINATED
Conditions: Delayed Graft Function|Kidney Transplantation|Complement Activity
Interventions: DRUG: Eculizumab|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Exclusive Use of Low Nicotine Cigarettes on Compensatory Smoking
Status: COMPLETED
Conditions: Smoking
Interventions: OTHER: Normal nicotine content cigarettes (NNC, Baseline)|OTHER: Very low nicotine content (VLNC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Impact of Whey and Soy Protein Ingestion in Conjunction With Energy Restriction in Overweight/Obese Individuals
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Weight loss|DIETARY_SUPPLEMENT: Soy|DIETARY_SUPPLEMENT: Whey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effectiveness of 2D Non-Navigated Intraoperative Ultrasound in Glioma Surgery
Status: COMPLETED
Conditions: Glioma|Glioma, Malignant|Low-grade Glioma|High-grade Glioma|Glioblastoma
Interventions: DIAGNOSTIC_TEST: intraoperative ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the 755nm Alexandrite Laser for Skin Toning and Epidermal Pigmented Lesions in Asian Skin Types
Status: COMPLETED
Conditions: Epidermal Pigmented Lesions|Skin Toning
Interventions: DEVICE: 755nm Alexandrite Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Pain Reduction for Limb Injuries in Pediatric Emergency Departments: Intranasal Fentanyl or Intranasal Ketamine vs Oral Morphine
Status: NOT_YET_RECRUITING
Conditions: Limb Injury
Interventions: DRUG: Morphine|DRUG: IN fentanyl|DRUG: IN ketamine|DRUG: NaCl 0,9 %
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cadiotocography Combined With ST-analysis Versus Cardiotocography Combined With Scalp-pH
Status: TERMINATED
Conditions: Metabolic Acidosis of Newborn
Interventions: DEVICE: Neoventa S 21 ST-ANalysis of fetal heart|PROCEDURE: CTG + FBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PR1-Specific Cytotoxic T-Lymphocyte Infusion With Recurrent Chronic Myelogenous Leukemia (CML) After Allogeneic Hematopoietic Transplantation
Status: WITHDRAWN
Conditions: Chronic Myelogenous Leukemia
Interventions: BIOLOGICAL: PR1-primed lymphocyte (PR1-CTL) Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dentoskeletal Changes Produced by Growth Modification Appliances in Treatment of Skeletal Class II Malocclusion
Status: COMPLETED
Conditions: Class II Division 1 Malocclusion|Mandibular Retrognathism
Interventions: DEVICE: Removable Twin Block|DEVICE: Fixed Functional , AdvanSync Appliance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Training the Innate Immune System Against SARS-CoV-2 (COVID-19) Using the Shingrix Vaccine in Nursing Home Residents
Status: COMPLETED
Conditions: Herpes Zoster|Allergy and Immunology|Corona Virus Infection
Interventions: BIOLOGICAL: SHINGRIX (Zoster Vaccine REcombinant, Adjuvanted)|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Soy Isoflavone Tablets: Effects on Sleep, Quality of Life, Symptoms and Cognitive Function in Menopausal Women
Status: COMPLETED
Conditions: Hot Flashes
Interventions: DRUG: soy isoflavones|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effects of a New Upper Limb Robot Assisted Therapy Device for Persons After Stroke
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: Training with new upper limb robot assisted therapy device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Immunogenicity and Safety of LBVD(Hexavalent Vaccine), Given to Healthy Infants at Primary Series
Status: NOT_YET_RECRUITING
Conditions: Diphtheria|Tetanus|Pertussis|Hepatitis B|Poliomyelitis|Haemophilus Influenzae Type B Infection
Interventions: BIOLOGICAL: LBVD (Hexavalent vaccine)|BIOLOGICAL: Pentavalent vaccine and Inactivated Polio vaccine (Sabin strains)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pathogenesis of Compromised Bone Quality and Mechanics in Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease|End Stage Kidney Disease|Chronic Kidney Disease Mineral and Bone Disorder|Renal Osteodystrophy|Secondary Hyperparathyroidism
Interventions: OTHER: Kidney disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effectiveness of Improving Self-care After Counseling for the Diabetics Mellitus Foots Around Chiayi Region
Status: UNKNOWN
Conditions: Diabetic Foot|Type 2 Diabetes Mellitus With Established Diabetic Nephropathy
Interventions: PROCEDURE: Michigan Neuropathy Screening Instrument
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Pilot Assessment of the Effects of Bardoxolone Methyl on Renal Perfusion, Systemic Haemodynamics and Cardiac Function in Patients With Chronic Kidney Disease and Type 2 Diabetes
Status: WITHDRAWN
Conditions: Renal Insufficiency, Chronic|Diabetes Mellitus, Type 2
Interventions: DRUG: Bardoxolone Methyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of PeptiStrong and Exercise to Enhance Muscle Strength in Young Subjects
Status: RECRUITING
Conditions: Muscle Injury
Interventions: DIETARY_SUPPLEMENT: PeptiStrong|DIETARY_SUPPLEMENT: Placebo SMCC silicated micro-crystalline cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer
Status: WITHDRAWN
Conditions: Anaplastic Ependymoma|Atypical Teratoid/Rhabdoid Tumor|Central Nervous System Germ Cell Tumor|Choroid Plexus Carcinoma|Intracranial Myeloid Sarcoma|Malignant Brain Neoplasm|Malignant Glioma|Medulloblastoma|Primitive Neuroectodermal Tumor|Recurrent Anaplastic Ependymoma|Recurrent Atypical Teratoid/Rhabdoid Tumor|Recurrent Malignant Brain Neoplasm|Recurrent Malignant Glioma|Recurrent Medulloblastoma|Recurrent Primitive Neuroectodermal Tumor
Interventions: DRUG: Etoposide|DRUG: Fludarabine Phosphate|PROCEDURE: Hematopoietic Cell Transplantation|BIOLOGICAL: Lapine T-Lymphocyte Immune Globulin|DRUG: Melphalan|DRUG: Mycophenolate Mofetil|DRUG: Tacrolimus|DRUG: Thiotepa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Safety and Efficacy of Switching to Tenofovir Disoproxil From Tenofovir Disoproxil Fumarate in Patients With Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis b
Interventions: DRUG: Tenofovir disoproxil 245mg|DRUG: Tenofovir disoproxil fumarate 300mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Neuroinflammation and Cognitive Dysfunction After Abdominal Surgery
Status: COMPLETED
Conditions: Anesthesia|Surgery|Neurogenic Inflammation|Cognitive Disorders
Interventions: RADIATION: Positron emission tomography (PET) using [11C]PBR28
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Effectiveness of Antibiotic Prophylaxis in Children With a Previous Urinary Tract Infection
Status: UNKNOWN
Conditions: Urinary Tract Infections
Interventions: DRUG: antibiotic to reduce the recurrence of infection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy in Treating Women With Breast Cancer Who Have Undergone Surgery
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: epirubicin hydrochloride|DRUG: gemcitabine hydrochloride|DRUG: paclitaxel|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Light Emitting Diode (LED) for the Treatment of Wrinkles
Status: COMPLETED
Conditions: Skin Aging|Photoaging of Skin
Interventions: DEVICE: Sham light|DEVICE: LumiPhase-R™, OPUSMED Inc. Montreal, Canada
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pathophysiology of Uric Acid Nephrolithiasis
Status: RECRUITING
Conditions: Uric Acid Kidney Stone Disease
Interventions: DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sparing Parotid Ducts Via MRI Sialography for Reduced Patient Reported Xerostomia
Status: NOT_YET_RECRUITING
Conditions: Oropharynx Cancer|Head and Neck Cancer|Xerostomia
Interventions: RADIATION: standard radiotherapy|RADIATION: experimental radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Observatory of Patients With Chronic Lymphocytic Leukemia / Lymphocytic Lymphoma or Waldenstrom Disease Infected With COVID-19
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia, Lymphocytic Lymphoma or Waldenstrom Disease
Interventions: BEHAVIORAL: Data registry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ALACOVID Study for Vaccinated Subjects
Status: COMPLETED
Conditions: COVID-19 Respiratory Infection
Interventions: DRUG: 150 mg 5-ALAPhosphate + SFC|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Efficacy and Safety of INCB054707 in Participants With Vitiligo
Status: COMPLETED
Conditions: NonSegmental Vitiligo
Interventions: DRUG: INCB054707|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Effect of Caffeine Consumption in Patients Taking Oral Terbinafine
Status: NOT_YET_RECRUITING
Conditions: Terbinafine Adverse Reaction
Interventions: OTHER: Caffeinated Coffee|OTHER: Decaffeinated Coffee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigation of the Impact of Different Application Volumes of Insulin Aspart in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Insulin aspart|DRUG: Insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Drug-drug Interactions and Safety Among JP-1366, Amoxicillin, and Clarithromycin in Healthy Volunteers
Status: COMPLETED
Conditions: Helicobacter Pylori Associated Gastrointestinal Disease
Interventions: DRUG: JP-1366 20mg 1capsule|DRUG: Amoxicillin 500Mg Cap|DRUG: Clarithromycin 500Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Impending Ulcers Associated With Hammer, Mallet and Claw Toe Deformities in the Diabetic Patient Setting
Status: COMPLETED
Conditions: Diabetic Foot|Hammer Toe|Mallet Toe|Claw Toe
Interventions: PROCEDURE: Tenotomy(cutting) of flexor tendons is performed with needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSD
Status: RECRUITING
Conditions: Post Traumatic Stress Disorder|Alcohol Use Disorder
Interventions: DRUG: Topiramate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: VEGF Trap in Treating Patients With Relapsed or Refractory Solid Tumors or Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: ziv-aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Methylglyoxal (MGO) Lowering Cocktail to Reduce Appetite in Obese Individuals
Status: NOT_YET_RECRUITING
Conditions: Obesity|Aging
Interventions: DRUG: Gly-low|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Between Aceclofenac 200 mg and Esomeprazole 20 mg in Healthy Male Volunteers
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: Aceclofenac|DRUG: Esomeprazole|DRUG: Aceclofenac and Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized and Cell-based Antitumor Immunization MVX-ONCO-1 in Advanced HNSCC
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: OTHER: MVX-ONCO-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epigenetic Priming Using Azacitidine With Neoadjuvant Chemotherapy for Resectable Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer|Malignant Neoplasm of Cardio-esophageal Junction of Stomach
Interventions: DRUG: Azacitidine|DRUG: Oxaliplatin|DRUG: Epirubicin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Effects of WISE Program Improving Frailty Status and Quality of Life for Adolescents With CHD
Status: WITHDRAWN
Conditions: Frailty
Interventions: BEHAVIORAL: with WISE (Walking Instruction based on Self-Efficacy)|BEHAVIORAL: without WISE (Walking Instruction based on Self-Efficacy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CTC Quantification During TURBT and PKVBT of Transitional Cell Carcinoma in Purging Fluid and Blood
Status: RECRUITING
Conditions: Urinary Bladder Neoplasm|Transitional Cell Carcinoma|Urogenital Neoplasms|Circulating Tumor Cell|Neoplasms
Interventions: DEVICE: Bipolar transurethral resection of bladder tumor (TURBT)|DEVICE: Bipolar transurethral plasma kinetic vaporization of bladder tumor (PKVBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study Evaluating the Safety and Efficacy of BioTTT001 in Patients With Malignant Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Solid Tumor
Interventions: BIOLOGICAL: BioTTT001 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Marathon Polyethylene and Enduron Polyethylene Acetabular Liners Used in Total Hip Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis|Arthritis|Joint Diseases|Musculoskeletal Diseases|Rheumatic Diseases
Interventions: DEVICE: Total Hip Replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contralateral Head Rotation on Internal Jugular Vein to Carotid Artery Distance and Overlap Ratio
Status: COMPLETED
Conditions: Central Venous Catheterization|Surgery
Interventions: PROCEDURE: Triangle of Sedillot identification using ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Image Mining and ctDNA to Improve Risk Stratification and Outcome Prediction in NSCLC Applying Artificial Intelligence.
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DIAGNOSTIC_TEST: Assess the role of baseline image mining, ctDNA data and their combination in patient staging and risk stratification
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Comparing Veliparib Plus Carboplatin and Paclitaxel Versus Placebo Plus Carboplatin and Paclitaxel in Previously Untreated Advanced or Metastatic Squamous Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: Carboplatin|DRUG: Veliparib|DRUG: Paclitaxel|DRUG: Placebo to veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: concomitant temozolomide (TMZ)|RADIATION: radiotherapy|DRUG: procarbazine|DRUG: adjuvant temozolomide (TMZ)|DRUG: CCNU|DRUG: vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Triple Artemisinin-based Combination Therapy for Delaying Drug Resistance Development - a Randomized Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: Uncomplicated Plasmodium Falciparum Malaria
Interventions: DRUG: Artemether-lumefantrine and Amodiaquine Drug Combination|DRUG: Artemether-lumefantrine then Artesunate amodiaquine|DRUG: Artemether-lumefantrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Citicoline in Treatment of Newborns With Hypoxic Ischemic Encephalopathy
Status: UNKNOWN
Conditions: Hypoxic-Ischemic Encephalopathy
Interventions: DRUG: citicoline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Between 180 mg and 60 mg ALXN2050 Tablets and Food Effect on ALXN2050 Pharmacokinetics
Status: COMPLETED
Conditions: Healthy Adult Participants
Interventions: DRUG: Treatment A|DRUG: Treatment B|DRUG: Treatment C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of ALKS 5461 for the Treatment of Major Depressive Disorder (MDD) - the FORWARD-3 Study
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: ALKS 5461|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Safety and Acute Effects of a Lower-limb Powered Dermoskeleton in Patients With Neuromuscular Disorders
Status: RECRUITING
Conditions: Muscular Dystrophies|Congenital Myopathy|Idiopathic Inflammatory Myopathies|Mitochondrial Myopathies|Glycogen Storage Disease
Interventions: DEVICE: Lower-limb powered dermoskeleton
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: CC100: Phase 1 Multiple-Dose Safety and Tolerability in Subjects With ALS
Status: UNKNOWN
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: CC100|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Fortification With Folic Acid and Vitamin B12 Among Teenage Girls
Status: RECRUITING
Conditions: Folate Deficiency|Vitamin B 12 Deficiency|Anemia, Megaloblastic|Cognitive Development|Depressive Symptoms
Interventions: DIETARY_SUPPLEMENT: Folic acid and vitamin B12 fortified flour|OTHER: Unfortified cereal flour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Thorough QT/QTc Study to Evaluate the Effects of an Intravenous Infusion of Eravacycline (TP-434) on Cardiac Repolarization
Status: COMPLETED
Conditions: Normal Healthy Subjects
Interventions: DRUG: Eravacyline, Moxifloxacin, and placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adaptive Radiation Therapy (ART) Stereotactic Ablative Body Radiotherapy (SABR) for Primary Localized Prostate Cancer
Status: RECRUITING
Conditions: Localized Prostate Adenocarcinoma|Stage I Prostate Cancer AJCC v8|Stage II Prostate Cancer AJCC v8|Stage III Prostate Cancer AJCC v8
Interventions: PROCEDURE: Computed Tomography|PROCEDURE: Cone-Beam Computed Tomography|RADIATION: Image-Guided Adaptive Radiation Therapy|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Stereotactic Ablative Radiotherapy|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Bilirubin Estimates in Newborns From Smartphone Digital Images in a Population in Botswana
Status: RECRUITING
Conditions: Neonatal Jaundice|Neonatal Hyperbilirubinemia
Interventions: DEVICE: Picterus App
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of a Breathing and Relaxation Technique in Antenatal Education
Status: RECRUITING
Conditions: Pregnancy
Interventions: BEHAVIORAL: BreLax: Antenatal education class|BEHAVIORAL: Standard care (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Improving the Eating Habits of Mother and Her Infant Via Sugar Reduction
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: BEHAVIORAL: Sugar reduction health education program|BEHAVIORAL: Control health education program|OTHER: Home water delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Topical Recombinant Human Vascular Endothelial Growth Factor (Telbermin) for Induction of Healing of Chronic, Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Foot Ulcer
Interventions: DRUG: rhuMAb VEGF (telbermin)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Harmonized Interventions to Maintain Health Via Appropriate Risk Factor Modification and Lifestyle Changes in Pediatric, Adolescent and Young Adult Cancer Survivors Pilot Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure|Cardiotoxicity|Cancer
Interventions: BEHAVIORAL: Cardio-oncology Rehabilitation (CORE)|BEHAVIORAL: Support
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Investigate The Effect Of 28 Days Of Dosing With GW856553 On Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: GW856553
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Ceritinib (LDK378) in Glioblastoma Multiforme and CNS Metastasis
Status: COMPLETED
Conditions: Glioblastoma|Brain Metastases
Interventions: DRUG: ceritinib 750mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Penicillin Allergy Testing in STD Clinics
Status: COMPLETED
Conditions: Penicillin Allergy
Interventions: DRUG: Penicillin Major Determinant (PrePen) Skin Testing|DRUG: Direct Oral challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Transcranial Direct Current Stimulation on Human Brains: A Neuroimaging Study
Status: COMPLETED
Conditions: Chronic Schizophrenia
Interventions: DEVICE: Transcranial direct current stimulation|DEVICE: Transcranial direct current stimulation - Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of Long-term Effects of Vedolizumab Subcutaneous in Adults With Ulcerative Colitis and Crohn's Disease
Status: COMPLETED
Conditions: Colitis, Ulcerative|Crohn's Disease
Interventions: DRUG: Vedolizumab SC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of MLN8237 in Participants With Advanced Hematological Malignancies
Status: COMPLETED
Conditions: B-cell Follicular Lymphoma|B-cell Marginal Zone Lymphoma|Diffuse Large B-cell Lymphoma|B-cell Mantle Cell Lymphoma|B-cell Small Lymphocytic Lymphoma|B-Cell Chronic Lymphocytic Leukemia|Multiple Myeloma|Waldenstrom's Macroglobulinemia|Noncutaneous Peripheral T-cell Lymphoma Not Otherwise Specified|Angioimmunoblastic T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Enteropathy Associated T-cell Lymphoma|NK Lymphoma
Interventions: DRUG: Alisertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role OF OCT-A TO Detect Possible Retinal Vascular Complications of Sofosbuvir in Patients With Hepatitis C
Status: UNKNOWN
Conditions: HCV Infection
Interventions: DEVICE: Optical coherence tomography angiography|DRUG: Sofosbuvir (Sovaldi)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Pharmacology of FYU-981 (Subjects With Renal Insufficiency)
Status: COMPLETED
Conditions: Renal Insufficiency|Healthy
Interventions: DRUG: FYU-981, (Oral single dosing)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multicenter Prospective Trial of Office-based Carpal Tunnel Release With Ultrasound Guidance (ROBUST)
Status: ACTIVE_NOT_RECRUITING
Conditions: Carpal Tunnel Syndrome|CTS
Interventions: DEVICE: Ultrasound Guided Carpal Tunnel Release (CTR-US)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tachyphylaxis, Tolerance, & Withdrawal Post Treatment With Igalmi for Agitation in Schizophrenia or Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder|Schizophrenia|Agitation,Psychomotor|Schizo Affective Disorder|Schizophreniform Disorders
Interventions: DRUG: Sublingual film containing Igalmi
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Epithelial Ovarian Cancer|Primary Peritoneal|Fallopian Tube Cancer|Newly Diagnosed|FIGO Stage III-IV|Partial Response|Complete Response
Interventions: DRUG: Rucaparib|DRUG: Nivolumab|DRUG: Placebo Oral Tablet|DRUG: Placebo IV Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pulsed Shortwave Therapy Treatment for Chronic Musculoskeletal Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: DEVICE: Pulsed Shortwave Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparative Effectiveness of Prophylactic ICD Versus Non-ICD Therapy
Status: NOT_YET_RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: PROCEDURE: ICD implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Enteral Nutrition in Cancer Patients
Status: COMPLETED
Conditions: Malnutrition|Cancer
Interventions: DIETARY_SUPPLEMENT: industrialized oral supplementation (IOS) and tube feeding regimen (TFR) with Nutren
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, Tolerability of Vabomere Compared to Best Available Therapy in Treating Serious Infections in Adults
Status: COMPLETED
Conditions: Urinary Tract Infection Complicated|Acute Pyelonephritis|Hospital Acquired Bacterial Pneumonia|Ventilator-associated Bacterial Pneumonia|Bacteremia|Abdominal Infection
Interventions: DRUG: Vabomere|DRUG: Best Available Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of CT-868 in Overweight and Obese Participants With Type 2 Diabetes Mellitus
Status: UNKNOWN
Conditions: Obesity|Type2 Diabetes
Interventions: DRUG: Placebo|DRUG: CT-868
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Management Of Low Output Recurrent Colonic Fistula Or Leak After Anterior Resection For Rectal Cancer
Status: COMPLETED
Conditions: Colonic Fistula
Interventions: PROCEDURE: endoscopy management of low output colonic fistula or leak after anterior resection for rectal cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Delayed Cord Clamping in Preterm Neonates With Placental Insufficiency
Status: COMPLETED
Conditions: Preterm Infant|Placental Insufficiency|Placental Transfusion
Interventions: PROCEDURE: Delayed cord clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Administration of T Lymphocytes for Hodgkin's Lymphoma and Non-Hodgkin's Lymphoma (CART CD30)
Status: WITHDRAWN
Conditions: Non-Hodgkin's Lymphoma|Hodgkin's Lymphoma
Interventions: DRUG: CAR.CD30 T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Safety of Sintilimab + XELOX + Bevacizumab in pMMR/MSS CRLM Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer Metastatic
Interventions: DRUG: Sintilimab|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Safety and Efficacy of Adalimumab in the Treatment of Pyoderma Gangrenosum
Status: WITHDRAWN
Conditions: Pyoderma Gangrenosum
Interventions: DRUG: adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Goal-directed Therapy Guided by Stroke Volume Variation and Cardiac Index in Non-severe Surgical Patients
Status: COMPLETED
Conditions: Fluid Therapy
Interventions: DEVICE: cardiac index|DEVICE: Stroke Volume Variation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Atezolizumab-Based Combination Therapy in Men With Localized Prostate Cancer Prior to Radical Prostatectomy
Status: RECRUITING
Conditions: Prostate Adenocarcinoma|Prostate Cancer|Localized Prostate Cancer
Interventions: DRUG: Atezolizumab|DRUG: Tocilizumab|DRUG: Etrumadenant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of a Nutritional Supplement to Treat Diabetic Symptoms in HIV-Infected Adults
Status: COMPLETED
Conditions: Insulin Resistance|HIV Infections
Interventions: DIETARY_SUPPLEMENT: chromium picolinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of F-627 in Women With Breast Cancer Receiving Myelotoxic Chemotherapy
Status: COMPLETED
Conditions: Neutropenia|Breast Cancer
Interventions: DRUG: F-627|DRUG: EC regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home Self-Testing for HIV to Increase HIV Testing Frequency in Men Who Have Sex With Men (The iTest Study)
Status: COMPLETED
Conditions: HIV
Interventions: BEHAVIORAL: Home HIV self-testing with OraQuick ADVANCE® Rapid HIV-1/2 Antibody Test|DEVICE: Home HIV self-testing with OraQuick ADVANCE® Rapid HIV-1/2 Antibody Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effects of Acupuncture at ST36 and PC6 on Blood Pressure and Endothelial Dysfunction in Hypertensive Patients
Status: UNKNOWN
Conditions: Hypertension
Interventions: PROCEDURE: acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Thoracic Interfascial Plane Nerve Block Versus Erector Spinae Plane Block for Pain Control After Modified Radical Mastectomy
Status: NOT_YET_RECRUITING
Conditions: Postoperative Pain Following Modified Radical Mastectomy for Breast Cancer
Interventions: PROCEDURE: Thoracic Interfascial Plane Block|PROCEDURE: Erector Spinae Plane Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bridges2Scale: Testing Implementation Strategies
Status: RECRUITING
Conditions: HIV/AIDS
Interventions: BEHAVIORAL: Financial Literacy Training (FLT) workshops|BEHAVIORAL: Mentorship|BEHAVIORAL: Income Generation Activity (IGA)|BEHAVIORAL: Youth Development Accounts (YDA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Computer Assisted Planning of Corrective Osteotomy for Distal Radius Malunion
Status: COMPLETED
Conditions: Extra-articular Distal Radius Malunions
Interventions: PROCEDURE: Corrective osteotomy with computer-assisted pre-operative planning|PROCEDURE: Corrective osteotomy with conventional preoperative planning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT