pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Impact of a Human Papilloma Virus (HPV) Vaccine in HIV-Infected Young Women
Status: COMPLETED
Conditions: HIV Infection
Interventions: BIOLOGICAL: HPV vaccine for strains -6, -11, -16, and -18
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications
Status: COMPLETED
Conditions: Uveitis|Iritis|Iridocyclitis|Anterior Uveitis|Macular Edema
Interventions: DRUG: Diclofenac|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Effect of Multiple Doses of Esomeprazole on the Pharmacokinetics of Isavuconazole
Status: COMPLETED
Conditions: Pharmacokinetics of Isavuconazole|Healthy Subjects
Interventions: DRUG: Isavuconazole|DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neural Glides With and Without Therapeutic Ultra Sound on in Pregnant Computer Workers With Carpal Tunnel Syndrome
Status: RECRUITING
Conditions: Pregnancy Related
Interventions: OTHER: Nerve Glide Exercise with Ultra Sound|OTHER: Nerve Glide Exercise without Ultra Sound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of SHR-1210 Combined With Apatinib in the Treatment of Sarcoma
Status: UNKNOWN
Conditions: Sarcoma
Interventions: DRUG: Camrelizumab,|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anesthetic Effect of Lidocaine/Epinephrine Solution Delivered Via Iontophoresis to External Auditory Apparatus
Status: COMPLETED
Conditions: Acute Otitis Media|Chronic Otitis Media|Recurrent Acute Otitis Media
Interventions: DEVICE: Iontophoresis System (Acclarent)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Prospective Randomized Pilot Study to Compare Open Versus Percutaneous Syndesmosis Repair of Unstable Ankle Fractures
Status: UNKNOWN
Conditions: Fracture Dislocation of Ankle Joint
Interventions: PROCEDURE: open reduction internal fixation (ORIF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Relative Bioavailability of BIBF 1120 Soft Gelatine Capsules Charge 1, BIBF 1120 Soft Gelatine Capsules Charge 2 and BIBF 1120 Drinking Solution in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIBF 1120 capsules charge 1|DRUG: BIBF 1120 capsules charge 2|DRUG: BIBF 1120 drinking solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assess the Efficacy and Safety of Rhinocort Aqua
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Budesonide|DRUG: Budesonide|DRUG: Budesonide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study With Catumaxomab in Patients With Gastric Cancer After Neoadjuvant CTx and Curative Resection
Status: COMPLETED
Conditions: Gastric Cancer|Gastric Adenocarcinoma
Interventions: DRUG: Catumaxomab|DRUG: catumaxomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRetest prObability of Infectious ENDOCARDITIS for Appropriate Criteria Regarding Transesophageal ECHOcardiography in Tertiary Care Facilities (PRO ENDOCARDITIS ECHO-Study)
Status: COMPLETED
Conditions: Infective Endocarditis
Interventions: DIAGNOSTIC_TEST: Transesophageal Echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of BCMA-directed CAR-T Cells Treatment in Subjects With r/r Multiple Myeloma
Status: UNKNOWN
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: BIOLOGICAL: C-CAR088
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ChangE From Any Systemic psoriasiS therapY to Raptiva
Status: TERMINATED
Conditions: Chronic Plaque Psoriasis
Interventions: DRUG: Efalizumab - anti CD11a recombinant human monoclonal antibody (mAb)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Early Mobilization on Mechanical Ventilation Duration in Intubated Critically Ill Patients
Status: UNKNOWN
Conditions: ICU Acquired Weakness
Interventions: PROCEDURE: Protocolized early mobilization in ICU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Exercise Prescription in Cardiac Rehabilitation
Status: COMPLETED
Conditions: Percutaneous Coronary Intervention|Myocardial Infarction|Coronary Artery Bypass Graft
Interventions: BEHAVIORAL: Graded Exercise Stress test (GXT) with Target Heart Rate Range|BEHAVIORAL: Heart rate monitors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Triptorelin Pamoate 6-month When Given to Adult Chinese Participants With Advanced Cancer in the Prostate
Status: COMPLETED
Conditions: Advanced Prostate Cancer|Metastatic Prostate Cancer|Locally Advanced Prostate Cancer
Interventions: DRUG: Triptorelin pamoate (embonate) salt
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: G-PUR® for Reduced Lead Bioavailability
Status: COMPLETED
Conditions: Lead Exposure
Interventions: DEVICE: G-PUR® 2x 2.0 g oral suspension|DEVICE: G-PUR® 1x 2.0 g oral suspension|DEVICE: Placebo oral suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Central Incisors Narrow Implants in Alternative to Bone Augmentation With 4.2 mm Implants .
Status: UNKNOWN
Conditions: Upper Central Incisor Edentulism
Interventions: DEVICE: ICE dental implant 4.2 mm|DEVICE: NICE dental implant 3.2 mm|DEVICE: Alpha Bio's Graft Bovine bone|DEVICE: Alpha Bio's Graft resorbable membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction of Labor With Oxytocin: When Should Oxytocin be Held?
Status: COMPLETED
Conditions: Labor Induction|Cesarean Delivery
Interventions: DRUG: Oxytocin|DRUG: Oxytocin discontinuation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BONDING TO ENAMEL USING A UNIVERSAL ADHESIVE
Status: COMPLETED
Conditions: Clinical Trial
Interventions: COMBINATION_PRODUCT: 1-step self-etch approach (SE)|COMBINATION_PRODUCT: selective enamel etching (SEE)|OTHER: 1-step self-etch for double time (SE2X)|OTHER: 1-step self-etch additional layer (SE1+)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: This Trial is a Clinical Performance Validation Study That Will Evaluate the Clinical Agreement of the Sky Medical™ Rapid Antigen Test Comparing the Antigen Rapid Test to RT-PCR
Status: UNKNOWN
Conditions: COVID-19|Sars-CoV-2 Infection
Interventions: DIAGNOSTIC_TEST: Sky Medical™ Rapid Antigen Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Chronicling the COPD Patient Journey and Change in COPD Symptoms, Quality of Life and Exacerbations Following Initiation of Budenoside/Glycopyrronium/Formoterol [BGF]
Status: NOT_YET_RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Budenoside/Glycopyrronium/Formoterol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Community-based Perinatal and Newborn Care in Gilgit District, Northern Areas, Pakistan: an AKU-AKHSP Collaboration
Status: COMPLETED
Conditions: Perinatal Problems|Still Births|Neonatal Deaths
Interventions: BEHAVIORAL: Health Education & Promotion|OTHER: Training of Health Workers|BEHAVIORAL: Community Mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Intake of Beta-glucan and Postprandial Regulation of Blood Glucose Metabolism in Healthy Subjects
Status: COMPLETED
Conditions: Post Prandial Blood Glucose|Gut Microbiota|Satiety
Interventions: OTHER: 0.5 g beta-glucan|OTHER: 3.5 g beta-glucan|OTHER: 8 g beta-glucan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of PEP503(Radio-enhancer) With Radiotherapy and Chemotherapy for Patients With Rectal Cancer
Status: TERMINATED
Conditions: Rectal Cancer
Interventions: DRUG: PEP503|DRUG: 5-fluorouracil|DRUG: capecitabine|PROCEDURE: surgical resection|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recollect the Game: A Novel Treatment for Executive Functioning Deficits in Adults With ADHD
Status: ACTIVE_NOT_RECRUITING
Conditions: Adult ADHD
Interventions: OTHER: Recollect, the game|OTHER: Tetris
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of Lanreotide (Autogel 120 mg) in Patients With Acromegaly
Status: COMPLETED
Conditions: Acromegaly
Interventions: DRUG: lanreotide (Autogel formulation), duration of treatment 46-48 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: [18F]-AZAFOL AS POSITRON EMISSION TOMOGRAPHY (PET) TRACER in FR Positive Cancer Imaging
Status: COMPLETED
Conditions: Metastatic Cancer Lung|Metastatic Ovarian Cancer
Interventions: DRUG: [18F]-AzaFol|DRUG: folarell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of IBI311 in Subjects With Steroid-resistant, Thyroid Associated Ophthalmopathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Thyroid Associated Ophthalmopathy
Interventions: DRUG: Placebo|DRUG: IBI311
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acupressure for Children in Treatment for a Childhood Cancer
Status: COMPLETED
Conditions: Treatment-Related Cancer
Interventions: OTHER: Acupressure for Children in Treatment for a Childhood Cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Regeneron AA Multicenter (Dupilumab)
Status: RECRUITING
Conditions: Alopecia Areata
Interventions: DRUG: Dupilumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Carpal Tunnel Release Under Local Anaesthesia With or Without Distal Median Nerve Block
Status: RECRUITING
Conditions: Carpal Tunnel Syndrome
Interventions: PROCEDURE: Local infiltration anaesthesia in carpal tunnel release|PROCEDURE: Distal median nerve block with local infiltration anaesthesia in carpal tunnel release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Magnesium Sulfate on Onset and Duration of Low Dose Rocuronium
Status: COMPLETED
Conditions: Observation of Neuromuscular Block|Intubation Condition|Surgical Condition
Interventions: DRUG: magnesium sulfate 30 mg/kg|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of ARGX-113 in Patients With ITP
Status: COMPLETED
Conditions: Primary Immune Thrombocytopenia
Interventions: DRUG: ARGX-113|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Virus-like Particle (VLP) Vaccine
Status: COMPLETED
Conditions: Covid19
Interventions: BIOLOGICAL: SARS-CoV-2 VLP Vaccine-Wuhan|BIOLOGICAL: SARS-CoV-2 VLP Vaccine-Alpha (British) variant|BIOLOGICAL: SARS-CoV-2 VLP Vaccine-Wuhan+Alpha variant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Magnetic Resonance (MR) Enterography Assessment of Post Operative Small Bowel Length in Short Bowel Syndrome Patients
Status: UNKNOWN
Conditions: Short Bowel Syndrome
Interventions: RADIATION: Barium follow-through and MR-enterography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Antagonism Research Between Antiemetics Agents and Acetaminophen in Thyroidectomy's Post-operative Analgesia.
Status: COMPLETED
Conditions: Interaction Between Antiemetic Drugs and Paracetamol
Interventions: DRUG: ondansetron|DRUG: Droperidol|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trans Auricular Vagus Nerve Stimulation (taVNS) and Robotic Training for Paralyzed Arm After Stroke
Status: RECRUITING
Conditions: Stroke|Hemiparesis
Interventions: DEVICE: In Motion Rehabilitation Robot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Mongersen (GED-0301) for the Treatment of Subjects With Active Crohn's Disease
Status: TERMINATED
Conditions: Crohn Disease
Interventions: DRUG: GED-0301|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Focused Cardiac Ultrasound in Hip Fracture Surgery (PrEcho)
Status: NOT_YET_RECRUITING
Conditions: Echocardiography|Hip Fractures|Risk Assessment|Anesthesia|Hemodynamic Instability
Interventions: DIAGNOSTIC_TEST: FOCUS echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ALIMTA Plus Carboplatin as Front-Line Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer: A Phase 2 Clinical Trial.
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: ALIMTA|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radioembolization of Primary and Secondary Liver Malignancies and The Effect On The Immune System
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Secondary Malignant Neoplasm of Liver
Interventions: OTHER: Yttrium-90
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Vitamin D on Retinal Changes in Patient With Optic Neuritis by Optic Coherence Tomography
Status: UNKNOWN
Conditions: Optic Neuritis
Interventions: DRUG: Vitamin D|DRUG: Vitamin D withheld
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Spherical Gelfoam Versus Tri-acryl Microsphere for Uterine Artery Embolization for Symptomatic Fibroids
Status: UNKNOWN
Conditions: Symptomatic Uterine Fibroids
Interventions: PROCEDURE: uterine artery embolization using spherical gelfoam|PROCEDURE: uterine artery embolization using tri-acryl gelatin microsphere
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Progressive Motor Imagery and Sensorimotor Exercises in Knee Osteoarthritis
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: BEHAVIORAL: Sensorimotor Exercise|BEHAVIORAL: Conventional Exercise|BEHAVIORAL: Progressive Motor Imagery Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety of Candidate gD Vaccine, With or Without MPL in Healthy Herpes Simplex Virus-positive Adults
Status: COMPLETED
Conditions: Herpes Simplex
Interventions: BIOLOGICAL: Herpes simplex candidate (gD) vaccine GSK208141
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Application of Machine Learning Method in Validation of Screening Cognitive Test for Parkinsonisms
Status: COMPLETED
Conditions: Primary Parkinsonism|Secondary Vascular Parkinson Disease|Multiple System Atrophy|Supranuclear Palsy, Progressive
Interventions: DIAGNOSTIC_TEST: CoMDA associated with Neural Net 91 classificator
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rib Fixation for Clinically Severe Rib Fractures From Trauma
Status: UNKNOWN
Conditions: Rib Fracture|Flail Chest
Interventions: DEVICE: Rib Fixation System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Performance of PicoWayTM Picosecond Fractional Laser for Acne Scars
Status: UNKNOWN
Conditions: Acne Scars - Mixed Atrophic and Hypertrophic
Interventions: DEVICE: PicoWay device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability, and Pharmacokinetics Study of AP303 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: AP303 50 μg|DRUG: AP303 150 μg|DRUG: AP303 300 μg|DRUG: AP303 600 μg|DRUG: Placebo 50 μg|DRUG: Placebo 150 μg|DRUG: Placebo 300 μg|DRUG: Placebo 600 μg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Nivolumab and Ipilimumab and Nivolumab Alone in Combination With Trans-arterial ChemoEmbolization (TACE) in Participants With Intermediate Stage Liver Cancer
Status: TERMINATED
Conditions: Cancer, Hepatocellular
Interventions: DRUG: nivolumab|DRUG: ipilimumab|PROCEDURE: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of QVA149 (110/50 μg o.d.) vs Tiotropium (18 µg o.d.) + Salmeterol/Fluticasone Propionate FDC (50/500 µg b.i.d.) in Patients With Moderate to Severe COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: QVA149|DRUG: Tiotropium|DRUG: Salmeterol/fluticasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PROPHESYS 2: An Observational Study on Predictors of Response in Treatment-naïve Patients With Chronic Hepatitis C Treated With Pegasys (Peginterferon Alfa-2a) or Peginterferon-alfa-2b
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Peginterferon alfa-2a [Pegasys]|DRUG: Peginterferon alfa-2b [PegIntron®]
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage III Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: Gemcitabine|DRUG: paclitaxel|DRUG: vinorelbine|RADIATION: radiation therapy|DRUG: Navelbine|DRUG: Taxol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Phase 2 Study of Atezolizumab (an Engineered Anti-PDL1 Antibody) Compared With Docetaxel in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Failed Platinum Therapy - "POPLAR"
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Docetaxel|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Efficacy of Zilucoplan in Subjects With Generalized Myasthenia Gravis
Status: COMPLETED
Conditions: Myasthenia Gravis, Generalized
Interventions: DRUG: zilucoplan (RA101495)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Embolic Signals Detection Study (Esds) in Candidates for Surgical Carotid Revascularisation
Status: COMPLETED
Conditions: Carotid Stenosis|Carotid Artery Diseases|Carotid Atherosclerosis|Carotid Artery Plaque|TCD|Stroke
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Determining the Optimal Dose of Tenecteplase Before Endovascular Therapy for Ischaemic Stroke (EXTEND-IA TNK Part 2)
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: Tenecteplase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Applying Eye-Gaze Assistive Technology for Children and Youth With Complex Needs
Status: COMPLETED
Conditions: Self-Help Devices|Eye-Gaze Technology|Severe Physical Disabilities|Communication Disorders
Interventions: DEVICE: Eye gaze AT intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maintenance rTMS for Treatment-resistant Depression (TRD): a One-year Double Blind Controlled Study
Status: UNKNOWN
Conditions: Major Depressive Disorder
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Vitamin D Substitution Weekly or Monthly and Adherence
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DRUG: Vitamin D: liquid form, start weekly|DRUG: Vitamin D: liquid form, start monthly|DRUG: Vitamin D: solid form, start weekly|DRUG: Vitamin D: solid form, start monthly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurovascular Coupling in Subjects With Amblyopia
Status: UNKNOWN
Conditions: Amblyopia ex Strabismus|Amblyopia ex Anisometropia
Interventions: DEVICE: Dynamic Vessel Analyzer|OTHER: Laser Doppler Velocimetry|DEVICE: 7-Tesla MRI|OTHER: Pattern electroretinography|OTHER: Fourier domain optical coherence tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Bioequivalence Study of Norgestimate /Ethinyl Estradiol (NGM/EE) Tablets Manufactured at 2 Different Facilities
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Norgestimate /Ethinyl estradiol tablets (NGM/EE) (Wet Process)|DRUG: Norgestimate /Ethinyl estradiol tablets (NGM/EE) (Dry Process)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose-response Study of Tranexamic Acid in Total Hip Arthroplasty
Status: RECRUITING
Conditions: Arthropathy of Hip
Interventions: DRUG: Placebo|DRUG: Group 1: perfusion of 300 mg Exacyl|DRUG: Group 2: perfusion of 500 mg Exacyl|DRUG: Group 3: perfusion of 1000 mg Exacyl|DRUG: Group 4: perfusion of 3000 mg Exacyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Open Label, Placebo-Controlled Study to Evaluate the Effect of GSK1349572 on Iohexol and Para-Aminohippurate Clearance in Healthy Subjects
Status: COMPLETED
Conditions: Infections, Human Immunodeficiency Virus and Tuberculosis
Interventions: DRUG: GSK1349572|DRUG: Placebo|DRUG: Iohexol Injection|DRUG: Para-aminohippurate infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Establishing Clinical Utility for a New Diagnostic Test for Patients With Shortness of Breath
Status: COMPLETED
Conditions: Dyspnea|Unexplained Chronic Dyspnea
Interventions: OTHER: Education Materials and Janssen Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Randomized, Placebo-Controlled, Double-Blind, Double Dummy Trial To Determine The Relative Effect Of Pm101 Versus Placebo And Amiodarone IV On Blood Pressure In Subjects With Stable Congestive Heart Failure
Status: WITHDRAWN
Conditions: Blood Pressure
Interventions: DRUG: amiodarone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Human Care Model-Based Nursing Interventions on Psychosocial Adjustment
Status: COMPLETED
Conditions: Outpatients|Defibrillators, Implantable
Interventions: BEHAVIORAL: Human Care Model Based Nursing Interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Avapro in Obese Normotensive/Hypertensive African Americans
Status: UNKNOWN
Conditions: Hypertension|Obesity|Stress, Psychological|Blood Pressure
Interventions: DRUG: Irbesartan|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reolysin in Previously Treated Advanced/Metastatic, Non Small Cell Lung Cancer Receiving Standard Salvage Therapy
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Pemetrexed and Reolysin (and safety run-in)|DRUG: Pemetrexed|DRUG: Docetaxel and Reolysin|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study - Auricular Vagus Nerve Stimulation Effects on Cardiovascular Parameters
Status: UNKNOWN
Conditions: Modulation of Cardiovascular Parameters and Sympathovagal Balance in Healthy Subjects
Interventions: DEVICE: PrimeStim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Feasibility of Dynamic Liquid Biopsy Monitoring During Neoadjuvant Treatment for EGFR-mutated NSCLC
Status: NOT_YET_RECRUITING
Conditions: EGF-R Positive Non-Small Cell Lung Cancer
Interventions: OTHER: ctDNA monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Second Open-Label Extension of a Double-Blind, Parallel, Phase IV Study to Assess the Efficacy and Safety of Adjunctive Lovaza® (Formerly Known as Omacor®) Therapy in Hypertriglyceridemic Subjects Treated With Antara™
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DRUG: Antara (fenofibrate) + Lovaza (omega-3-acid ethyl esters)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Korean Red Ginseng on Oxidation in Middle-aged and Elderly Sub-health Population
Status: RECRUITING
Conditions: Healthy Ageing|Antioxidative Stress
Interventions: DRUG: Korean red ginseng capsule (marketed product in Korea)|DRUG: Korean red ginseng capsule(placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ph 1 Study of ADI-PEG 20 Plus Low Dose Cytarabine in Older Patients With AML
Status: TERMINATED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: ADI-PEG 20|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AMG 529 First in Human Study
Status: COMPLETED
Conditions: Cardiovascular
Interventions: DRUG: AMG 529|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Subcuticular Suture for Cesarean Skin Incision Closure
Status: COMPLETED
Conditions: Complications; Cesarean Section|Surgical Wound Infection
Interventions: DEVICE: poliglecaprone 25 suture|DEVICE: polyglactin 910 suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Orvepitant (GW823296) in Adult Post Traumatic Stress Disorder
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: DRUG: orvepitant|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomimetic Stent and Drug Eluting Balloon to Treat Recurrent Cephalic Arch Stenosis
Status: COMPLETED
Conditions: Brachiocephalic Vein Stenosis
Interventions: DEVICE: Passeo-18 Lux and SUPERA® stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Explore Correlation Between Symptoms and Signs of Polycystic Ovarian Syndrome (PCOS) and Risk of Over-response to Ovarian Stimulation
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Gonal-f®|DRUG: Long GnRH agonist|DRUG: GnRH antagonist
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Opioid Sparing Analgesia Continuous Intraoperative Infusion of Dexmedetomidine Versus Lidocaine for Laparoscopic Cholecystectomy
Status: NOT_YET_RECRUITING
Conditions: Analgesia
Interventions: DRUG: Dexmedetomidine Injection [Precedex]|DRUG: Lidocaine IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Does Peri-Operative Gabapentin Reduce Chronic Post-Thoracotomy Pain?
Status: WITHDRAWN
Conditions: Post-thoracotomy Pain
Interventions: DRUG: Gabapentin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Impact of Home Delivery of Antiretroviral Therapy on Virological Suppression
Status: COMPLETED
Conditions: HIV|Community Health Workers|Antiretroviral Therapy, Highly Active
Interventions: OTHER: ART home delivery|OTHER: Enhanced nutrition counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Additional Autoimmune Diseases With Type 1 Diabetes in Pediatrics at Diabetes Diagnosis and During Follow-up
Status: UNKNOWN
Conditions: Type 1 Diabetes|Autoimmune Diseases|Hashimoto Disease|Graves Disease|Celiac Disease|Addison Disease|Vitiligo
Interventions: OTHER: No intervention.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 139 in Healthy Subjects and Subjects With Moderate to Severe Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: AMG 139
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Cannabis on Pain and Inflammation Among Patients With Rheumatoid or Psoriatic Arthritis
Status: TERMINATED
Conditions: Rheumatoid Arthritis|Psoriatic Arthritis
Interventions: DRUG: Cannabis: placebo and medium THC/medium CBD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pulmonary Rehabilitation in Functional Outcomes and Its Relationship With Morbidity and Mortality in Patients With COPD
Status: TERMINATED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: Pulmonary rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trimetazidine Efficacy in Attenuating Paclitaxel-Induced Peripheral Neuropathy
Status: RECRUITING
Conditions: Peripheral Neuropathy Due to Chemotherapy
Interventions: DRUG: Trimetazidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Magnetic Resonance Imaging in Measuring the Effect of Cabozantinib in Patients With Castrate Resistant Prostate Cancer
Status: COMPLETED
Conditions: Bone Metastases|Castrate-resistant Prostate Cancer|Recurrent Prostate Cancer|Stage IV Prostate Cancer
Interventions: DRUG: cabozantinib|OTHER: laboratory biomarker analysis|PROCEDURE: magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dual-task Performance in Young-onset PD
Status: UNKNOWN
Conditions: Early Onset Parkinson Disease|Early Stage Parkinson Disease
Interventions: OTHER: Game based dual-task training|OTHER: Treadmill training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of A-PRF+ on Postoperative Outcomes Following Surgical Removal of Impacted Mandibular Third Molars (A-PRF+: Advanced Platelet Rich Fibrin)
Status: COMPLETED
Conditions: PRF
Interventions: COMBINATION_PRODUCT: A-PRF+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Using Educational Modules Via Bedside Tablet in Newly Diagnosed Type 1 Diabetes
Status: SUSPENDED
Conditions: Type 1 Diabetes Mellitus
Interventions: OTHER: Molly Center Diabetes Care Guide (Paper-based)|OTHER: Tablet based interactive diabetes education modules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Auditory Performances With Different Stimulation Depths in Cochlear Implanted Subjects Using a Fine Structure Strategy
Status: RECRUITING
Conditions: Sensorineural Hearing Loss, Bilateral
Interventions: DEVICE: FineHearing Strategy with 10 more apical electrodes or with 10 more basal electrodes activated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Potential Role of CD9 and Implication of Motility Process in Pathogenesis of TEL/ALM1-positive ALL Relapses (LAL TEL/ALM1 and CD9).
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia (ALL)
Interventions: OTHER: Impact of CD9 expression level on motility assays|OTHER: Post-transcriptional regulation of CD9
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of ORGN001 (Formerly ALXN1101) in Neonates, Infants and Children With Molybdenum Cofactor Deficiency (MOCD) Type A
Status: COMPLETED
Conditions: Molybdenum Cofactor Deficiency, Type A
Interventions: DRUG: ORGN001 (formerly ALXN1101)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Daylight Photodynamic Therapy for Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratoses
Interventions: DRUG: Aminolevulinic Acid Topical 20% Topical Solution|DEVICE: BLU-U blue light phototherapy illuminator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Infusion of rhIL-15 for Adults With Advanced Cancer
Status: COMPLETED
Conditions: Lymphoma|Carcinoma
Interventions: BIOLOGICAL: rh IL-15 (10 DAYS)|BIOLOGICAL: rh IL-15 (5 DAYS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Preference for Subcutaneous Trastuzumab Treatment in Participants With Human Epidermal Growth Factor Receptor (HER)2-Positive Metastatic Breast Cancer Responding to First-Line Intravenous Trastuzumab for at Least 3 Years
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imaging Analysis Following Periodontal Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Healing Wound|Periodontitis
Interventions: PROCEDURE: Simplified papilla preservation flap|PROCEDURE: Resective periodontal flap with osseous recontouring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Drug Study of Albuterol to Treat Acute Lung Injury
Status: TERMINATED
Conditions: Respiratory Distress Syndrome, Adult
Interventions: DRUG: Albuterol Sulfate|PROCEDURE: Mini-Bronchoalveolar Lavage (BAL)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: INvestigation of TENS Efficacy Versus Posterior Tibial Nerve Stimulation for Overactive Bladder
Status: RECRUITING
Conditions: Overactive Bladder|Overactive Bladder Syndrome|Urinary Urge Incontinence|Urinary Bladder, Overactive|Urinary Incontinence, Urge
Interventions: DEVICE: PTNS|DEVICE: TENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Letrozole and Laparoscopic Ovarian Drilling in Women With Clomiphene Resistant Polycystic Ovarian Syndrome (PCOS)
Status: UNKNOWN
Conditions: Infertility
Interventions: DRUG: Letrozole|PROCEDURE: Laparoscopic ovarian drilling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Viramidine to Ribavirin in Patients With Chronic Hepatitis C Who Are Treatment Naive
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Viramidine|DRUG: Ribavirin|DRUG: pegylated interferon alfa-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Neoantigen Vaccine Combined With Targeted Drugs in the Treatment of Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: neoantigen vaccine + EGFR-TKI|DRUG: neoantigen vaccine + anti-angioge
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online CBT-I for High Blood Pressure
Status: COMPLETED
Conditions: Hypertension|Prehypertension|Insomnia
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Healthy Sleep Habits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Safety and Efficacy of the Percutaneous Reduction of Mitral Valve Regurgitation in Heart Failure Patients
Status: SUSPENDED
Conditions: Heart Failure|Mitral Regurgitation
Interventions: DEVICE: PTMA (Percutaneous Transvenous Mitral Annuloplasty) Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopy-assisted Pylorus-vagus Nerve Preserving Gastrectomy in the Treatment of Early Gastric Cancer
Status: UNKNOWN
Conditions: Early Gastric Cancer
Interventions: PROCEDURE: Pylorus preservation|PROCEDURE: Distal gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV Infection
Status: COMPLETED
Conditions: HIV Infections|Peripheral Nervous System Disease
Interventions: DRUG: Mexiletine hydrochloride|DRUG: Benztropine mesylate|DRUG: Amitriptyline hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Vinblastine, Celecoxib, and Combination Chemotherapy in Treating Patients With Newly-Diagnosed Metastatic Ewing's Sarcoma Family of Tumors
Status: COMPLETED
Conditions: Sarcoma
Interventions: DRUG: celecoxib|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: vinblastine sulfate|DRUG: vincristine sulfate|PROCEDURE: conventional surgery|RADIATION: radiation therapy|DRUG: MESNA|DRUG: Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abuse Potential of Orally Administered Crushed Embeda Compared to Crushed Controlled-Release Morphine and Placebo in Non-Dependent Recreational Opioid Users
Status: COMPLETED
Conditions: Nondependent Opioid Abuse, Episodic
Interventions: DRUG: Placebo|DRUG: MS Contin (morphine sulfate, controlled release)|DRUG: EMBEDA (morphine sulfate / naltrexone hydrochloride)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Efficacy and Safety of Hyeonggaeyeongyo-tang for Chronic Rhinitis According to Pattern Identification in Korean Medicine
Status: COMPLETED
Conditions: Respiratory Tract Diseases|Nose Diseases|Rhinitis
Interventions: DRUG: Hyeonggaeyeongyo-tang
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Epigallocatechin-3-gallate (EGCG) for Esophagus Protection in Patients With Lung Cancer Receiving Radial Radiotherapy
Status: UNKNOWN
Conditions: Lung Neoplasms|Esophagitis|Prevention & Control|Epigallocatechin Gallate
Interventions: DRUG: EGCG|DRUG: EGCG|DRUG: mLDG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: IH636 Grape Seed Extract in Preventing Breast Cancer in Postmenopausal Women at Risk of Developing Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DIETARY_SUPPLEMENT: IH636 grape seed proanthocyanidin extract
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [11C]PBR28 in HIV-Seropositive Patients With (MCMD)
Status: TERMINATED
Conditions: HIV-Dementia|HIV-Associated Cognitive Motor Complex|AIDS Encephalopathy|AIDS Dementia Complex|AIDS-Related Dementia Complex|HIV Infections|Healthy
Interventions: DRUG: [11C]PBR28
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Adj. Marker-adjusted Personalized Therapy Comparing ET+Ribociclib vs Chemotherapy in Intermediate Risk, HR+/HER2- EBC
Status: RECRUITING
Conditions: Breast Cancer Female
Interventions: DRUG: Ribociclib 200Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label, MultiCenter Evaluation of the Use of Topically Administered FP1198 in Subjects With Pain Associated With Cyclic Mastalgia
Status: COMPLETED
Conditions: Moderate to Severe Cyclic Mastalgia
Interventions: DRUG: Danazol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Trial to Evaluate Mass Balance of Tavapadon at Steady State in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Tavapadon tablet|DRUG: Tavapadon [14C] suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid Infusion of Cold Normal Saline During CPR for Patients With Out-of-hospital Cardiac Arrest
Status: COMPLETED
Conditions: Out-of-hospital Cardiac Arrest
Interventions: PROCEDURE: PARAMEDIC COOLING
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT