pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Paclitaxel-coated Balloon for Treatment of De-novo Non-complex Coronary Artery Lesions
Status: ACTIVE_NOT_RECRUITING
Conditions: De Novo Stenosis|Coronary Artery Disease
Interventions: DEVICE: Paclitaxel coated balloon|DEVICE: Sirolimus eluting stents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Routine Versus Selective Midtrimester Ultrasound in a Poorly Resourced Setting: a Cluster Randomised Controlled Trial
Status: COMPLETED
Conditions: Fetal Congenital Abnormalities|Prolonged Pregnancy|Multiple Pregnancy
Interventions: PROCEDURE: Routine midtrimester pregnany ultrasound scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Azacitidine Plus Phenylbutyrate in Treating Patients With Advanced or Metastatic Solid Tumors That Have Not Responded to Previous Treatment
Status: COMPLETED
Conditions: Lymphoma|Small Intestine Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: Azacitidine Injection|DRUG: sodium phenylbutyrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plasma Exchange in Patients With COVID-19 Disease and Invasive Mechanical Ventilation: a Randomized Controlled Trial
Status: TERMINATED
Conditions: Coronavirus
Interventions: BIOLOGICAL: Plasma exchange|DRUG: Standar medical treatmen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study of Civamide Nasal Solution (Zucapsaicin) for the Treatment of Episodic Cluster Headache
Status: COMPLETED
Conditions: Episodic Cluster Headache
Interventions: DRUG: Civamide (Zucapsaicin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: ASKB589 in Combination With CAPOX and Sintilimab in Patients With Advanced, and Unresectable G/GEJ Cancer.
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: ASKB589 +CAPOX+Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Rehabilitation (Mega Team) and Its Effects on Emotional and Behavioral Regulation in ADHD, ASD, and CHD
Status: UNKNOWN
Conditions: ADHD|ASD|CHD - Congenital Heart Disease
Interventions: OTHER: Mega Team - video game
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: US PROmyBETAapp2.0: A Study to Learn More About the Medication Usage and Patient Reported Outcomes Via the myBETAapp in Medical Care of Patients With Multiple Sclerosis Treated With BETASERON Using BETACONNECT Autoinjector
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Interferon-beta-1b (BETASERON, BAY 86-5046)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Topical 2% Lidocaine for the Treatment of Symptomatic Hemorrhoids
Status: UNKNOWN
Conditions: Hemorrhoids
Interventions: DRUG: 2% lidocaine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Antiviral Activity and Safety of HH-003 Injection in Subjects With HBeAg-Negative Chronic Hepatitis B Treated With Nucleos(t)Ide Reverse Transcriptase Inhibitors
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: NrtIs|DRUG: HH-003|DRUG: HH-003+NrtIs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Two Investigational Pneumococcal Vaccines in Healthy Adults
Status: COMPLETED
Conditions: Pneumococcal Infections|Streptococcus Pneumoniae Infections|Pneumococcal Pneumonia
Interventions: BIOLOGICAL: Pneumococcal Vaccine Formulation 1|BIOLOGICAL: Pneumococcal Vaccine Formulation 2|BIOLOGICAL: Pneumococcal Vaccine Formulation 3|BIOLOGICAL: Pneumococcal Vaccine Formulation 4|BIOLOGICAL: Pneumococcal Vaccine Formulation 5|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Infliximab Biosimilar "Pfizer" Drug Use Investigation (Crohn's Disease or Ulcerative Colitis)
Status: COMPLETED
Conditions: Crohn's Disease|Ulcerative Colitis
Interventions: DRUG: Infliximab [infliximab biosimilar 3]
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cardiovascular, Renal and Metabolic Profile in Patients With Acute Myocardial Infarction (REN-ACS)
Status: UNKNOWN
Conditions: Hypertension, Renovascular|Renal Artery Stenosis|Myocardial Infarction
Interventions: PROCEDURE: renal artery angiography|PROCEDURE: coronarography|PROCEDURE: coronary angioplasty|PROCEDURE: pulse wave velocity measurement|PROCEDURE: body composition monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Alteplase for Percutaneous Treatment of Loculated Abdominopelvic Abscesses
Status: COMPLETED
Conditions: Abdominal Abscess|Pelvic Abscess
Interventions: DRUG: Alteplase|OTHER: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Direct Oral Anticoagulation Versus Vitamin K Antagonist After Cardiac Surgery Trial
Status: RECRUITING
Conditions: Bleeding Post Cardiac Surgery|Indication for Anticoagulation
Interventions: DRUG: DOAC|DRUG: VKA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using ANDS to Reduce Harm for Low SES Cigarette Smokers
Status: ACTIVE_NOT_RECRUITING
Conditions: Smoking, Cigarette|Nicotine Dependence
Interventions: OTHER: Nicotine (electronic cigarette)|OTHER: Nicotine (nicotine pouch)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TeamCare PCN: Collaborative Care for Diabetes and Depression
Status: COMPLETED
Conditions: Depression|Depressive Symptoms|Type 2 Diabetes
Interventions: OTHER: TeamCare Depression Intervention|OTHER: Usual diabetes and depression care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Mizagliflozin on Postprandial Glucose and Insulin in Post-Bariatric Hypoglycemia Subjects
Status: COMPLETED
Conditions: Postbariatric Hypoglycemia
Interventions: DRUG: Mizagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hedonic Perception and Brain Activity Response to Meal
Status: COMPLETED
Conditions: Dyspepsia
Interventions: DEVICE: Functional brain MRI|DIETARY_SUPPLEMENT: A warm ham and cheese sandwich and a 200 ml fruit juice
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Is There Increased Polyethylene Wear and Increased Periprosthetic Bone Loss in Femur in Reverse Hybrid Technique Compared With Conventional Cemented Technique in Total Hip Replacement?
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: OTHER: Total hip replacement, Spectron and Taperloc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Severe Bullous Drug Eruption and Filgrastim
Status: RECRUITING
Conditions: Rare Diseases|Toxic Epidermal Necrolyses
Interventions: DRUG: Filgrastim|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving In-hospital Stroke Service Utilisation in China
Status: COMPLETED
Conditions: Thrombolytic Therapy|Acute Stroke|Door to Treatment Time|Quality Improvement
Interventions: BEHAVIORAL: Behaviour Change Wheel model guided intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Medical ANtiarrhythmic Treatment or Radiofrequency Ablation in Ischemic Ventricular Tachyarrhythmias
Status: UNKNOWN
Conditions: Myocardial Infarction|Ventricular Tachyarrhythmia
Interventions: PROCEDURE: Radiofrequency catheter ablation|DRUG: Antiarrhythmic drug therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study Assessing a New Scale to Measure Onset of Action in Generalized Anxiety Disorder
Status: COMPLETED
Conditions: Anxiety Disorders
Interventions: DRUG: lorazepam|DRUG: placebo|DRUG: paroxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A RCT of a Fully-automated Self-help AEBT Website
Status: COMPLETED
Conditions: AEBT Website With Check-ins|AEBT Website Without Check-ins
Interventions: BEHAVIORAL: Acceptance-Enhanced Behavior Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between Single , Intra- Cluster and Double-injection Ultrasound-guided Supraclavicular Block of Brachial Plexus
Status: UNKNOWN
Conditions: Regional Anesthesia Morbidity
Interventions: PROCEDURE: single injection supraclavicular brachial pleuxus block|PROCEDURE: intracluster injection supraclavicular brachial pieuxus block|PROCEDURE: double injection supraclavicular brachial pleuxus block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomized Double Blind Protocol Comparing Amphotericin B With Flucytosine to Amphotericin B Alone Followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal Meningitis
Status: COMPLETED
Conditions: Meningitis, Cryptococcal|HIV Infections
Interventions: DRUG: Itraconazole|DRUG: Flucytosine|DRUG: Fluconazole|DRUG: Amphotericin B
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Examining the Impact of Nicotine Pouches in Rural Ohio and Ohio Appalachia
Status: RECRUITING
Conditions: Tobacco-Related Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Nicotine Oral Pouch|DRUG: Nicotine Oral Pouch|OTHER: Questionnaire Administration|DRUG: Smokeless Tobacco
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of Curcumin, Vorinostat, and Sorafenib
Status: WITHDRAWN
Conditions: Advanced Cancers
Interventions: DRUG: Curcumin|DRUG: Sorafenib|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Non-nutritive Sucking on Feeding Intolerance
Status: RECRUITING
Conditions: Non-nutritive Sucking
Interventions: OTHER: non-nutritive sucking 5 minutes|OTHER: non-nutritive sucking 15 minutes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Negative Affect in Individuals With Binge Eating Episodes
Status: ACTIVE_NOT_RECRUITING
Conditions: Bulimia Nervosa|Binge-Eating Disorder|Obesity|Eating Disorder
Interventions: BEHAVIORAL: Negative Affect Task
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Bioequivalence Study of Alfuzosin 10 mg Prolong-released Tablets Under Fed Conditions
Status: NOT_YET_RECRUITING
Conditions: Healthy Volunteer
Interventions: DRUG: Alfuzosin Hydrochloride 10 mg Prolonged-release Tablets|DRUG: Xatral® XL 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: RCHOP Chemoimmunotherapy Preceded BY BBB Permeabilization by t-NGR Necrosis Factor
Status: COMPLETED
Conditions: Lymphoma, Large B-Cell, Diffuse
Interventions: DRUG: NGR-hTNF|OTHER: RITUXIMAB|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Vincristine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC
Status: RECRUITING
Conditions: Systemic Inflammatory Response Syndrome|Postoperative Pain, Acute|Postoperative Pain, Chronic|Infections Postoperative|Opioid Use|Anesthesia|Non-small Cell Lung Cancer
Interventions: DRUG: Opioid-Based Anesthesia-Analgesia Strategy|DRUG: Opioid-free Anesthesia-Analgesia Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pranayama and Diaphragmatic Breathing Exercise Applied to Female Patients With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: BEHAVIORAL: Pranayama|BEHAVIORAL: diaphragm breathing exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pilot Study to Assess the Effect of a Postbiotic Blend on Moderate Self-reported Anxiety
Status: COMPLETED
Conditions: Anxiety
Interventions: DIETARY_SUPPLEMENT: Postbiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Plant and Animal Proteins on Amino Acid Concentrations
Status: COMPLETED
Conditions: Healthy Resistance-Trained Males
Interventions: OTHER: Animal Proteins (crossover)|OTHER: Plant-based protein blends type 1 (crossover)|OTHER: Plant-based protein blends type 2 (crossover)|OTHER: Plant-based protein blends type 3 (crossover)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate Plasmin for the Creation of a Posterior Vitreous Detachment
Status: TERMINATED
Conditions: Vitreoretinal Traction Syndrome
Interventions: DRUG: Plasmin|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of Periglottic Airway Devices With Performed Shape
Status: RECRUITING
Conditions: Airway Management
Interventions: DEVICE: Ventilation using the "Fastrach" intubating laryngeal mask airway and glottic view using fibrescope - Group A|DEVICE: Ventilation using the "Proseal" laryngeal mask airway and glottic view using fibrescope- Group B|DEVICE: Ventilation using the "I-gel" supraglottic airway device and glottic view using fibrescope- Group C|DEVICE: Ventilation using the "Protector" laryngeal airway device and glottic view using fibrescope- Group D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: To Analyze the Kinematic Change of Lower Limb During Jumping Task With Wearable Device - 2-year Program
Status: UNKNOWN
Conditions: Landing Error Scoring System (LESS)
Interventions: DEVICE: dynamic taping
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 3 Rollover Study of Lumacaftor in Combination With Ivacaftor in Subjects 12 Years and Older With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis, Homozygous or Heterozygous for the F508del-CFTR Mutation
Interventions: DRUG: Lumacaftor Plus Ivacaftor Combination|DRUG: Ivacaftor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Optimal Volume Voided for Passage of a Backfill-Assisted Voiding Trial Following Urogynecologic Surgery
Status: COMPLETED
Conditions: Voiding Dysfunction
Interventions: PROCEDURE: Control Group|PROCEDURE: Test Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of Metformin on Leptin Transport in Cerebrospinal Fluid of Obese Patients
Status: RECRUITING
Conditions: Obesity Without Type 2 Diabetes, With BMI>30
Interventions: DRUG: Metformin Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bioavailability and Food Effects of HRS-7535 Tablets With Different Formulating Processes in Healthy Subjects
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: HRS-7535（D）Tablets|DRUG: HRS-7535（C）Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin for Treatment of Psoriasis Combined With Disorders of Glucose and Lipid Metabolism
Status: UNKNOWN
Conditions: Psoriasis Vulgaris With Metabolic Disorders
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pharmacokinetics, Safety, And Tolerability Of Ertugliflozin (PF-04971729, MK-8835) In Japanese And Western Healthy Participants (MK-8835-041)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Ertugliflozin|DRUG: Placebo|DRUG: Ertugliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Arzoxifene or Tamoxifen in Preventing Breast Cancer in Premenopausal Women at High Risk for Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Hereditary Breast/Ovarian Cancer (brca1, brca2)
Interventions: DRUG: arzoxifene hydrochloride|DRUG: tamoxifen citrate|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The IMmunotherapy Pleural 5-ALA PDT
Status: RECRUITING
Conditions: Mesotheliomas Pleural|Malignant Pleural Mesothelioma
Interventions: DEVICE: intrapleural photodynamic therapy with videothoracoscopy|DRUG: Nivolumab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Three Protocols for Phenylephrine Administration in Cesarean Delivery
Status: COMPLETED
Conditions: Cesarean Section Complications|Spinal Anesthesia
Interventions: DRUG: Single shot phenylephrine|DRUG: Fixed infusion phenylephrine.|DRUG: Variable infusion phenylephrine.|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of an Immunosuppressant Mycophenolate Mofetil or MMF on the Urinary Sodium Excretion Response to Mental Stress
Status: UNKNOWN
Conditions: Psychological Stress|Hypertension, Renal
Interventions: DRUG: mycophenolate mofetil (MMF)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Ultrasonographic Appearance of the Endometrium After Ulipristalacetate Use and Endometrial Changes
Status: COMPLETED
Conditions: Uterine Fibroid|Endometrial Cyst
Interventions: DIAGNOSTIC_TEST: saline infusion sonography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Brexpiprazole in Treatment of Children and Adolescents With Irritability Associated With Autism Spectrum Disorder for Subjects That Have Completed Participation in 331-201-00148
Status: COMPLETED
Conditions: Irritability Associated With Autism Spectrum Disorder
Interventions: DRUG: Brexpiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CSD201203: A Study to Determine Subject Puffing Patterns of a Non-cylindrical, Closed, Electronic Nicotine Delivery System at Three Nicotine Concentrations in an Ambulatory Setting
Status: UNKNOWN
Conditions: Smoking|Tobacco Use|Electronic Cigarette Use
Interventions: OTHER: P1211216|OTHER: P1213416|OTHER: P1213716|OTHER: P1213616|OTHER: P1213816|OTHER: P1211916|OTHER: P1210016|OTHER: P1211217|OTHER: P1213417|OTHER: P1211222|OTHER: P1213422|OTHER: P1213722|OTHER: P1213622|OTHER: P1213822|OTHER: P1211922|OTHER: P1210022
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neoadjuvant Hypofractionated Stereotactic Body Radiation Therapy Prior to Surgery for Hepatocellular Carcinoma: a Feasibility Study.
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: COMBINATION_PRODUCT: Surgery with Neoadjuvant stereotactic body radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety, Efficacy, Tolerability, Pharmacokinetics and Pharmacodynamics of LNP023 in in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)
Status: COMPLETED
Conditions: Paroxysmal Nocturnal Hemoglobinuria (PNH) With Signs of Active Hemolysis
Interventions: DRUG: iptacopan|COMBINATION_PRODUCT: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Muscle Insulin Resistance in Aging (Mirage)
Status: ACTIVE_NOT_RECRUITING
Conditions: Insulin Resistance|Sarcopenia
Interventions: BEHAVIORAL: Exercise|BEHAVIORAL: Energy Restriction-Induced Weight Loss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Loratadine for Pegfilgrastim Induced Bone Pain in Patients With Aggressive Lymphoma
Status: TERMINATED
Conditions: Lymphoma
Interventions: DRUG: Pegfilgrastim|DRUG: Loratadine|OTHER: Placebo|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of Resistance Training in Patients With Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: OTHER: Resistance exercise|OTHER: Waiting list for the exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 2 Study of Poziotinib in Participants With NSCLC Having EGFR or HER2 Exon 20 Insertion Mutation
Status: TERMINATED
Conditions: NSCLC
Interventions: DRUG: Poziotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: INSIGHT, A Comprehensive, Multidisciplinary Brain Training System
Status: COMPLETED
Conditions: Cognitive Ability, General
Interventions: BEHAVIORAL: Cognitive Training - 48 sessions|BEHAVIORAL: Fitness|BEHAVIORAL: Active Control|DEVICE: active tDCS|DEVICE: sham tDCS|BEHAVIORAL: Cognitive Training - 20 sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Survival, Quality of Life and Resectability in Locally Advanced Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreas Cancer|Pancreas Neoplasm|Pancreas Disease|Pancreas Adenocarcinoma|Surgery|Chemotherapy Effect|Quality of Life|Locally Advanced Pancreatic Adenocarcinoma|Borderline Resectable Pancreatic Adenocarcinoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Oblimersen Sodium and Rituximab in Treating Patients With Recurrent B-cell Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Cutaneous B-cell Non-Hodgkin Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Testicular Lymphoma|Waldenström Macroglobulinemia
Interventions: BIOLOGICAL: oblimersen sodium|BIOLOGICAL: rituximab|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of Cabaser and Sinemet CR For The Treatment Of Nighttime Symptoms Associated With Parkinson's Disease.
Status: TERMINATED
Conditions: Parkinson Disease
Interventions: DRUG: cabergoline|DRUG: controlled-release levodopa / carbidopa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Cobimetinib in Newly Diagnosed or HMA-treated CMML Patients With RAS Pathway Mutations
Status: RECRUITING
Conditions: Chronic Myelomonocytic Leukemia (CMML)
Interventions: DRUG: Cobimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Atezolizumab and Chemotherapy (Carboplatin Plus Etoposide) in Neoadjuvant Treating Limited-Stage Small Cell Lung Cancer Patients
Status: UNKNOWN
Conditions: Small-cell Lung Cancer|Neoadjuvant Therapy
Interventions: DRUG: Atezolizumab|DRUG: Carboplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brief Behavioral Intervention for Insomnia During Chemotherapy
Status: COMPLETED
Conditions: Breast Cancer|Insomnia
Interventions: BEHAVIORAL: Brief Behavioral Therapy for Insomnia (BBT-I)|BEHAVIORAL: Healthy Eating Education Learning (HEAL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Virtual LV Lead Navigation in Patients With Ischemic Cardiomyopathy
Status: WITHDRAWN
Conditions: Cardiomyopathy|Ischemic Cardiomyopathy
Interventions: OTHER: Collection of measurements during LV pacing during electrophysiology study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Bevacizumab/Doxil in Treatment of Platinum-Resistant/Refractory Ovarian Cancer (CA)
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Doxil|DRUG: Avastin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of S5G4T-1 in the Treatment of Papulopustular Rosacea
Status: COMPLETED
Conditions: Papulopustular Rosacea
Interventions: DRUG: S5G4T-1|DRUG: S5G4T-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Pericapsular Nerve Group Block With Lumbar Erector Spinae Plain Block in Total Hip Arthroplasty Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Total Hip Arthroplasty
Interventions: OTHER: Procedure/Surgery: Regional Block Comparison Comparing postoperative pain and opioid consumption in groups
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study of Dasatinib Management Among CP-CML (Chronic Phase, Chronic Myeloid Leukemia) Participants Initiating Dasatinib in a Real Life Setting
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia
Interventions: OTHER: Non-Interventional
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Longitudinal Effect of Vitamin D3 Replacement on Cognitive Performance and MRI Markers in Multiple Sclerosis Patients
Status: UNKNOWN
Conditions: Multiple Sclerosis|Multiple Sclerosis, Relapsing-Remitting|Clinically Isolated Syndrome|Clinically Isolated Syndrome, CNS Demyelinating|Vitamin D3 Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Double-blind, Randomized, Parallel Group, Fase III Comparative Study With Rose Hip Powder Powder and Placebo Given to Patients With Mild to Moderate Osteoarthritis in the Knee or/and Hip
Status: COMPLETED
Conditions: Pain|Activities of Daily Living|Quality of Life
Interventions: DIETARY_SUPPLEMENT: Rose-hip powder capsules|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Posterior Capsulotomy in Cataract Complicated With Primary Posterior Capsule Opacification.
Status: UNKNOWN
Conditions: Cataract|Posterior Capsule Opacification
Interventions: PROCEDURE: posterior capsulotomy|PROCEDURE: laser capsulotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Association of Obesity and Cardiovascular Outcomes in Hypertrophic Cardiomyopathy
Status: RECRUITING
Conditions: Obesity|Hypertrophic Cardiomyopathy|Cardiovascular Morbidity
Interventions: OTHER: Diasgnosis of hypertrophic cardiomyopathy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Endoscopic Transcanal Tympanoplasty With Attico-antrostomy Versus Endoscopic-assisted Canal Wall up Mastoidectomy in Management of Localized Cholesteatoma: A Randomized Clinical Trial
Status: COMPLETED
Conditions: Cholesteatoma
Interventions: PROCEDURE: endoscopic transcanal tympanoplasty with attico-antrostomy|PROCEDURE: endoscopic assisted canal wall up mastoidectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Training Swallowing Initiation During Expiration
Status: RECRUITING
Conditions: Head and Neck Cancer|Dysphagia|Oropharyngeal Dysphagia|Oropharynx Squamous Cell Carcinoma
Interventions: BEHAVIORAL: Respiratory-Swallow Phase Training|OTHER: Swallow Practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Glycemic Variability on Autonomic Tone in Hospitalized Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes|Inpatient
Interventions: DRUG: Intravenous insulin|DRUG: Subcutaneous Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Heart-lung Interaction to Predict Haemodynamic Tolerance to the Open Lung Approach With Individualised PEEP
Status: RECRUITING
Conditions: Anesthesia|Perioperative/Postoperative Complications|Hypovolemia|Haemodynamic Instability
Interventions: DIAGNOSTIC_TEST: Tidal Volume Challenge|PROCEDURE: Recruitment maneuver obtaining individualised PEEP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Evaluating 5 Doses of RPL554 and Placebo in COPD Patients Via a Dry Powder Inhaler
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Part A: RPL554|DRUG: Part B: RPL554|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Iron Sucrose and Oral Iron Acetyl-transferrin Hydroglycerin
Status: COMPLETED
Conditions: Iron Deficiency Anemia
Interventions: DRUG: venoferrum(iron sucrose)|DRUG: Bolgre (Iron acetyl-transferase)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compass for Care: A Theory-driven Mobile Solution to Promote Well-being Among Caregivers of Individuals With ADRD
Status: ACTIVE_NOT_RECRUITING
Conditions: Dementia|Mental Health
Interventions: BEHAVIORAL: Compass for Care (Well-being intervention)|BEHAVIORAL: Compass for Care (Safety intervention)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ph 2 Study of TAS-102 / Bevacizumab Maintenance Therapy Post Induction Chemotherapy in Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: TAS-102|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Marstacimab to Compare Prefilled Pen (PFP) Device to Prefilled Syringe (PFS) Device
Status: TERMINATED
Conditions: Healthy Volunteers
Interventions: DRUG: Marstacimab PFP|DRUG: Marstacimab PFS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Continuous Epidural Analgesia Versus Continuous Supra-Inguinal Fascia Iliaca Block in Total Hip Replacement Surgery
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: PROCEDURE: continuous epidural analgesia|PROCEDURE: supra-inguinal fascia iliaca compartment block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuroprotective Role of Erythropoietin in Perinatal Asphyxia
Status: COMPLETED
Conditions: Perinatal Asphyxia
Interventions: DRUG: Erythropoietin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Trial of Magnetic Resonance (MR) Guided Focused Ultrasound Surgery (FUS) in Women With Uterine Fibroids Wishing to Pursue Pregnancy in the Future
Status: WITHDRAWN
Conditions: Uterine Fibroids|Pregnancy
Interventions: PROCEDURE: Magnetic Resonance Guided Focused Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Assessment of 4 Different Bearing Types in Hip Replacement Types to Analsye the Lowest Wear Rates of Polyethylene
Status: COMPLETED
Conditions: Arthroplasty Complications|Hip Arthritis
Interventions: DEVICE: Highly Cross Linked Polyethylene and oxidized zirconium femoral head
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: HAI Irinotecan + IV Bevacizumab, Bevacizumab & Oxaliplatin or Bevacizumab & Cetuximab in Advanced Cancers Metastatic to Liver
Status: COMPLETED
Conditions: Liver Cancer|Advanced Cancer
Interventions: DRUG: Irinotecan|DRUG: Bevacizumab|DRUG: Oxaliplatin|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eribulin Combined With Sintilimab as First-line Treatment for Unresectable Locally Advanced or Metastatic HER2-negative Breast Cancer:A Multicenter, Single-arm,Phase II Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Eribulin|DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In-office Repair of Chronic Tympanic Membrane Perforations
Status: NOT_YET_RECRUITING
Conditions: Chronic Tympanic Membrane Perforation
Interventions: DRUG: Fibroblast Growth Factor 2|DRUG: Saline control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Safety and Immunogenicity of Ferritin Nanoparticles Expressing Native-like HIV-1 Envelope Trimers Followed by Boost With mRNA Lipid Nanoparticles Encoding a Native-like HIV-1 Envelope Trimer in Adults Without HIV
Status: ACTIVE_NOT_RECRUITING
Conditions: Hiv
Interventions: DRUG: V3G CH848 Pr-NP1 60mcg|DRUG: 3M-052-AF 5mcg|DRUG: Alum 500 mcg|DRUG: V3G CH848 mRNA-Tr2 50mcg|DRUG: ACU-026-001-1 2.0mg|DRUG: V3G CH848 Pr-NP1 100mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Infusion of Prostacyclin vs Placebo for 72-hours in Trauma Patients With Haemorrhagic Shock Suffering From Organ Failure
Status: COMPLETED
Conditions: Multi Organ Failure
Interventions: DRUG: Iloprost|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder
Status: NOT_YET_RECRUITING
Conditions: Post Traumatic Stress Disorder
Interventions: DRUG: 3,4-methylenedioxymethamphetamine|DRUG: d-amphetamine|BEHAVIORAL: Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, Tolerability, and Pharmacokinetics of Indacaterol Maleate Via Concept1 or Simoon Devices
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Indacaterol 150 μg via the Concept1 dry-powder inhaler|DRUG: Indacaterol 60 μg via the Simoon dry-powder inhaler|DRUG: Indacaterol 120 μg via the Simoon dry-powder inhaler|DRUG: Placebo to indacaterol via the Concept1 dry-powder inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-emptive Scalp Infiltration With Methylprednisolone Plus Ropivacaine for Postoperative Pain After Craniotomy
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: The MP/RP group|DRUG: The RP group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Effect of LCZ696 on Aortic Stiffness in Subjects With Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: sacubitril/valsartan (LCZ696)|DRUG: olmesartan|OTHER: placebo to sacubitril/valsartan (LCZ696)|OTHER: placebo to olmesartan|DRUG: Amlodipine (Optional)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of a Percutaneous Mitral Valve Repair System.
Status: COMPLETED
Conditions: Mitral Valve Insufficiency|Mitral Valve Regurgitation|Mitral Valve Incompetence|Mitral Regurgitation|Mitral Insufficiency
Interventions: DEVICE: Percutaneous mitral valve repair (MitraClip Implant)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irinotecan Liposomes for the Treatment of Neuroendocrine Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Neuroendocrine Tumors
Interventions: DRUG: Irinotecan liposomes combined with cisplatin/carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes of Bipolar Electrocautery Tonsillectomy Versus Cold Steel Dissection Pediatric Tonsillectomy
Status: COMPLETED
Conditions: Tonsillitis
Interventions: PROCEDURE: Bipolar electrocautery tonsillectomy technique|PROCEDURE: Cold steel dissection technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effect of Osteopathic Visceral Mobilization Techniques
Status: RECRUITING
Conditions: Multiple Sclerosis|Pelvic Floor Disorders|Urinary Incontinence|Visceral Mobilization|Osteopathic Manipulative Treatment
Interventions: OTHER: breathing exercises|OTHER: osteopathic manual therapy techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: INCMGA00012 Plus Chemotherapy in Participants With Advanced Solid Tumors (POD1UM-105)
Status: WITHDRAWN
Conditions: Advanced and/or Metastatic Solid Tumors|Stage IIIB Not Amenable to Curative Therapy to Stage IV Non-small Cell Lung Cancer|Advanced/Metastatic Unresectable Malignant Pleural Mesothelioma
Interventions: DRUG: Retifanlimab|DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Pemetrexed|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Drug-drug Interaction of the Effects of Gemfibrozil and Rifampicin on SAR442168 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Tolebrutinib|DRUG: gemfibrozil|DRUG: rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-center Application of an AI System for Diagnosis of Cervical Lesions Based on Colposcopy Images
Status: RECRUITING
Conditions: Artificial Intelligence|Colposcopy|Cervical Lesions|Image
Interventions: DIAGNOSTIC_TEST: Artificial intelligence diagnosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Vaccine Therapy, Chemotherapy, and Radiation Therapy in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed With Surgery
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: recombinant fowlpox GM-CSF vaccine adjuvant|BIOLOGICAL: recombinant fowlpox-CEA(6D)/TRICOM vaccine|BIOLOGICAL: recombinant vaccinia-CEA(6D)-TRICOM vaccine|DRUG: carboplatin|DRUG: paclitaxel|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Autologous Transplantation of Bone Marrow Mononuclear Stem-Cells for Dilated Cardiomyopathy
Status: COMPLETED
Conditions: Dilated Cardiomyopathy
Interventions: PROCEDURE: intramyocardial bone marrow stem cells implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Antiemetic Efficacy of Akynzeo Plus Dexamethasone During Radiotherapy and Concomitant Weekly Cisplatin
Status: UNKNOWN
Conditions: Chemotherapy-induced Nausea and Vomiting|Adverse Event|Cervical Cancer
Interventions: DRUG: Akynzeo|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cleft Palate Surgery and Speech Development
Status: COMPLETED
Conditions: Cleft Lip|Cleft Palate
Interventions: PROCEDURE: Furlow double z-plasty palatoplasty palate repair|PROCEDURE: Von Langenbeck palatoplasty palate repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Periodontal Infection and Systemic Inflammation in Renal Patients
Status: COMPLETED
Conditions: Periodontitis|Chronic Kidney Disease
Interventions: PROCEDURE: Scaling root planing|PROCEDURE: Supragingival Prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Instrumental Analysis of Walking in People With Osseointegrated Prostheses for Lower Extremity Amputation: Comparative Evaluation With Traditional Socket Prostheses
Status: RECRUITING
Conditions: Lower Extremity Amputation
Interventions: DIAGNOSTIC_TEST: Test of standing balance (Equitest System). Test of walking in tied and split conditions on a force-sensorized split-belt treadmill.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Pharmacokinetic Study of Two Different Strengths of BAY14-2222
Status: COMPLETED
Conditions: Hemophilia A
Interventions: BIOLOGICAL: Recombinant Factor VIII (Kogenate FS, BAY14-2222)|BIOLOGICAL: Recombinant Factor VIII (Kogenate FS, BAY14-2222)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Olaparib and Navitoclax in Women With HGSC and TNBC
Status: RECRUITING
Conditions: High Grade Serous Carcinoma|Triple Negative Breast Cancer|Ovarian Cancer
Interventions: DRUG: Olaparib tablet|DRUG: Navitoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT