pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Controlled Randomized Stimulation Versus Resection (CoRaStiR)
Status: COMPLETED
Conditions: Epilepsy
Interventions: DEVICE: Implantation of an intracranial electrode|PROCEDURE: amygddohyppocampertomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Pharmacokinetics and Pharmacodynamics of Eculizumab in Patients With Paroxysmal Nocturnal Hemoglobinuria
Status: COMPLETED
Conditions: Paroxysmal Nocturnal Hemoglobinuria|Eculizumab|PK-PD
Interventions: OTHER: Blood collection for measurement of eculizumab peak concentrations
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Compare of PRP Autologous Serum and Autologous Serum by Intrastromal Injection in Different Eye Disease Conditions
Status: ENROLLING_BY_INVITATION
Conditions: PRP
Interventions: DRUG: PRP plasma rich platelets|DRUG: Autologous serum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3437943 in Healthy Participants and Participants With Impaired Renal Function
Status: COMPLETED
Conditions: Healthy|Renal Insufficiency
Interventions: DRUG: LY3437943
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Antiviral Study of ACH-126, 443 (Beta-L-Fd4C) in the Treatment of Adults With HIV Infection and Modestly Detectable Viral Load.
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: ACH126-443 (Beta-L-Fd4C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Robotic Versus Open Pancreaticoduodenectomy for Pancreatic and Periampullary Tumors
Status: UNKNOWN
Conditions: Pancreatic Adenocarcinoma|Pancreatic Cysts|Pancreatic Endocrine Tumors|Chronic Pancreatitis|Cholangiocarcinoma, Extrahepatic|Ampullary Adenocarcinoma|Duodenal Adenocarcinoma
Interventions: PROCEDURE: Robotic pancreaticoduodenectomy|PROCEDURE: Open pancreaticoduodenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial of SHR-1316 Maintenance Therapy for Limited Stage Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Limited-stage Small Cell Lung Cancer, LS-SCLC
Interventions: DRUG: SHR-1316
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flexible Footwear and Insole in Heel Pain
Status: COMPLETED
Conditions: Plantar Fasciitis of Right Foot (Disorder)|Heel Spur
Interventions: DEVICE: Flexible footwear|DEVICE: Orthopedic insole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Five Versus Seven Day Antibiotic Course for the Treatment of Pneumonia in the Intensive Care Unit
Status: COMPLETED
Conditions: Pneumonia, Bacterial
Interventions: OTHER: 5 Days of Antibiotics|OTHER: 7 Days of Antibiotics therapy for pneumonia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EUS Guided HVA and PVA for Circulating Tumor DNA in Patients
Status: RECRUITING
Conditions: Circulating Tumor Cell|Gastrointestinal Cancer
Interventions: DIAGNOSTIC_TEST: EUS-guided portal vein and hepatic vein aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Point-of-care Ultrasound Screening and Assessment of Chronic Liver Diseases and NASH
Status: UNKNOWN
Conditions: Liver Diseases|Liver Cirrhosis|NASH - Nonalcoholic Steatohepatitis|Non-Alcoholic Fatty Liver Disease|Fibrosis, Liver|Steatosis of Liver
Interventions: DEVICE: Ultrasound liver assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Lemborexant for Irregular Sleep-Wake Rhythm Disorder and Mild to Moderate Alzheimer's Disease Dementia
Status: COMPLETED
Conditions: Irregular Sleep-Wake Rhythm Disorder
Interventions: DRUG: Lemborexant 2.5 mg|DRUG: Lemborexant 5 mg|DRUG: Lemborexant 10 mg|DRUG: Lemborexant 15 mg|DRUG: Lemborexant-matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Dipyridamole of Asasantin p.o. in Three Experimental Formulations Relative to the Standard Formulation in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Asasantin ER (new formulation I - low)|DRUG: Asasantin ER (new formulation III - medium)|DRUG: Asasantin ER (new formulation II - high)|DRUG: Asasantin ER (present commercial formulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anesthetic Technique for AV Fistulae Creation
Status: TERMINATED
Conditions: End Stage Renal Failure on Dialysis
Interventions: PROCEDURE: regional anesthesia|PROCEDURE: local anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacologic Relapse Prevention for Alcoholic Smokers
Status: COMPLETED
Conditions: Alcoholism|Smoking
Interventions: DRUG: bupropion (Wellbutrin)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Formation and Severity of Pressure Ulcers Associated With 4% Albumin vs. 0.9% Sodium Chloride
Status: COMPLETED
Conditions: Pressure Ulcer, Area|Pressure Ulcer, Grade|Albumin Level|Risk Score|Length of ICU Stay
Interventions: DRUG: 4% Albumin / 0.9% Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Renal Mass Biopsy, PEER, and 99mTc-sestamibi SPECT/CT for Patients With Clinically Localized Renal Tumors
Status: RECRUITING
Conditions: Kidney Tumor|Renal Benign Neoplasm|Renal Malignant Tumor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of ONO-7579 in Patients With Advanced Solid Tumors/ NTRK Gene Fusion Positive Advanced Solid Tumors
Status: TERMINATED
Conditions: Solid Tumor
Interventions: DRUG: ONO-7579
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Synovectomy in Pain Reduction Following Total Knee Arthroplasty
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: Synovectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of Pertuzumab in Combination With Trastuzumab and Chemotherapy in Patients With HER2-Positive Advanced Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: Capecitabine|DRUG: Cisplatin|DRUG: Pertuzumab|DRUG: Pertuzumab|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cancer Screening Smoking Cessation AND Respiratory Assessment
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer|Protection Against Malignant Lung Neoplasm (Diagnosis)
Interventions: DIAGNOSTIC_TEST: Lung cancer screening with low dose CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Comparison of Mepitel Ag vs Antibiotic Ointment Used With Soft Cast Technique for Treatment of Pediatric Burns
Status: COMPLETED
Conditions: Burns
Interventions: DEVICE: triple antibiotic ointment dressing|DEVICE: Mepitel Ag
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Qingfei Granule for the Treatment of the Pediatric Acute Upper Respiratory Tract Infection With Bacterial Infection
Status: RECRUITING
Conditions: Upper Respiratory Tract Infection|Bacterial Infection|Chinese Medicine|Pediatric Acute Upper Respiratory Tract Infection
Interventions: DRUG: QingFei Granule|DRUG: Cefuroxime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Scapholunate Ligament Partial Tears; Tear Localization, Extrinsic Ligament Injury Association and Conservative Treatment Responses Prior to Instability
Status: COMPLETED
Conditions: Scapholunate Ligament Partial Tears
Interventions: PROCEDURE: Conservative Treatment (splint)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ampicillin for DYT-1 Dystonia Motor Symptoms
Status: COMPLETED
Conditions: DYT-1|Dystonia
Interventions: DRUG: Ampicillin|DRUG: Sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Visual Arts-based Intervention for Community-dwelling Stroke Survivors
Status: COMPLETED
Conditions: Stroke|Self Efficacy|Psychosocial Problem
Interventions: OTHER: Visual arts-based intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Acceptability of Low-Residue Diet Package (Enimaclin®) as Diet Control Before Colonoscopy
Status: COMPLETED
Conditions: Dietary Modification
Interventions: DIETARY_SUPPLEMENT: Enimaclin®|OTHER: Self-controlled diet|DRUG: 2L PEG-ELS|DRUG: low volume 1.5L PEG-ELS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose:
Clinical trial: OSA Risk Level in Dental Patients and Correlation With Complications After General Anesthesia
Status: RECRUITING
Conditions: Obstructive Sleep Apnea Risk Management|Postoperative Complications|Dental Caries Under General Anesthesia|Obstructive Sleep Apnea of Adult
Interventions: OTHER: The STOP-BANG questionnaire for determining OSA risk level.|OTHER: ASA recommended criteria for determining OSA risk level.|OTHER: Record of postoperative complications
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Umbilical Cord Derived Mesenchymal Stem Cells Transplantation for Active and Refractory Systemic Lupus Erythematosus
Status: UNKNOWN
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: human umbilical cord derived MSC transplantation for SLE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of MP-424, Peginterferon Alfa-2a (PEG-IFN Alfa-2a), and Ribavirin(RBV) in Treatment-Naïve or Relapsed Hepatitis C
Status: COMPLETED
Conditions: Chronic Hepatitis C (CHC)
Interventions: DRUG: MP-424|DRUG: RBV|DRUG: PEG-IFN alfa-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Microbial Protease Supplementation on Postprandial Amino Acid Levels
Status: COMPLETED
Conditions: Protein Metabolism
Interventions: DIETARY_SUPPLEMENT: Protease + Protein|DIETARY_SUPPLEMENT: Placebo + Protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Depression and Diabetes Control Trial
Status: COMPLETED
Conditions: Diabetes Mellitus|Affective Disorders|Depression|Depressive Symptoms|Emotional Distress|Diabetes Complications
Interventions: BEHAVIORAL: Diabetes-related affective problems analysis|BEHAVIORAL: Goal setting towards improvement of glycaemic control|BEHAVIORAL: Diabetes-specific problem-solving therapy|BEHAVIORAL: Interventions to increase diabetes treatment motivation|BEHAVIORAL: Activation of personal and social resources|BEHAVIORAL: Reduction of barriers to self-care/glycaemic control|BEHAVIORAL: Cognitive restructuring of diabetes-related problems|BEHAVIORAL: Goal definition regarding self-care/glycaemia/well-being|BEHAVIORAL: Health care and specific topics (e. g. blood pressure)|BEHAVIORAL: Healthy foods, cooking recommendations, recipes|BEHAVIORAL: Sports, activities and exercise|BEHAVIORAL: Foot care: exercises, care & control, injuries, neuropathy|BEHAVIORAL: Diabetes complications|BEHAVIORAL: Social aspects of living with diabetes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TMC114-C211: Trial of an Investigational Protease Inhibitor TMC114 With Ritonavir ("TMC114/r") in HIV-1 Infected Patients Who Have Never Been Treated With Antiretroviral Medications.
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: LPV/RTV|DRUG: TMC-114/RTV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propionyl-L-Carnitine in Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Propionyl-L-Carnitine|DRUG: Propionyl-L-Carnitine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Use of Entecavir for Non-Hodgkin's Lymphoma Patients With Resolved Hepatitis B
Status: COMPLETED
Conditions: Non Hodgkin's Lymphoma|Hepatitis B
Interventions: DRUG: Entecavir prophylaxis|DRUG: Therapeutic entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of an Early Screening Test of Chronic Rejection and of Operational Tolerance by MicroArray in Renal Graft (Protocol DPRC Array)
Status: TERMINATED
Conditions: First Cadaveric Renal Graft
Interventions: BIOLOGICAL: DNA chip
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Impact of Ranolazine on Coronary Microcirculatory Resistance
Status: COMPLETED
Conditions: Coronary Microcirculation|Coronary Artery Disease|Myocardial Disease|Ischemia
Interventions: DRUG: Rnalozine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study of Oxycodone 5 mg / Ibuprofen 400 mg Tablets Under Non-fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxycodone HCl 5 mg / Ibuprofen 400 mg tablets, single dose|DRUG: COMBONOX® tablets, single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Consumption of Black Cumin (Nigella Sativa L.) Water Extract on Weight Loss in Overweight Women
Status: WITHDRAWN
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Black cumin water extract as a traditional medicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Gastroenteric Anastomosis With New Tissue Apposing Stent in the Management of Antro-pyloroduodenal Obstruction : Evaluation of Feasibility, Efficacy and Tolerance.
Status: COMPLETED
Conditions: Antro-pyloric and/or Duodenal Benign or Malignant Obstructions
Interventions: RADIATION: HYALURONIQUE ACIDE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study of Mitapivat in Participants With Moderate Hepatic Impairment Compared to Matched Healthy Control Participants With Normal Hepatic Function
Status: COMPLETED
Conditions: Moderate Hepatic Impairment
Interventions: DRUG: Mitapivat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Protein Biomarker Levels in Tissue Samples From Young Patients With Low-risk Hodgkin Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: GENETIC: microarray analysis|GENETIC: protein expression analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lung Transplant G0 (LTGO): Improving Self-Management of Exercise After Lung Transplantation
Status: ACTIVE_NOT_RECRUITING
Conditions: Exercise|Lung Transplantation
Interventions: BEHAVIORAL: LTGO-Home Based Exercise|BEHAVIORAL: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prognostic Value of Ventricular Fibrillation Spectral Analysis in Sudden Cardiac Death
Status: COMPLETED
Conditions: Sudden Cardiac Death|Ventricular Fibrillation|Reperfusion Injury
Interventions: DIAGNOSTIC_TEST: Spectral analysis of ventricular fibrillation tracings
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Using Radiogenomics to Predict Malignant Potential of Intraductal Papillary Mucinous Neoplasms of the Pancreas
Status: RECRUITING
Conditions: Pancreatic Cancer|Pancreatic Cyst
Interventions: OTHER: Blood Sample collection|OTHER: Tissue sample collection|OTHER: Data collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Antioxidant and NMDA Receptor Blocker Wins Anoxic Brain Damage of KorEa OHCA Patients
Status: UNKNOWN
Conditions: Cardiac Arrest
Interventions: DRUG: Neu2000KWL High-dose group|DRUG: Neu2000KWL Low-dose group|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TAP Block vs External Oblique Plane Block for Laparoscopic Cholecystectomy Surgery
Status: COMPLETED
Conditions: Cholecystitis|Cholecystitis, Acute|Cholecystitis, Chronic
Interventions: DRUG: TAPB|DRUG: EOIB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Limitation of Ischemic Injury of a Kidney Stored in Machine Perfusion in Hypothermia - Evaluation of the Impact on Kidney Allograft Function
Status: COMPLETED
Conditions: Transplanted Kidney Ischemia Reperfusion Injury
Interventions: DRUG: etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dapagliflozin in Systemic Right Ventricle (DAPA-SERVE)
Status: RECRUITING
Conditions: Dapagliflozin Adverse Reaction|Efficacy|Systemic Right Ventricle
Interventions: DRUG: Dapagliflozin 10mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ECMO Hemostatic Transfusions in Children
Status: RECRUITING
Conditions: Extracorporeal Membrane Oxygenation Complication|Hemorrhage|Thromboembolism|Transfusion Adverse Reaction
Interventions: BIOLOGICAL: Platelet Transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Butrans for Treatment of Restless Legs Syndrome
Status: WITHDRAWN
Conditions: Restless Legs Syndrome
Interventions: DRUG: buprenorphine transdermal delivery system (BTDS)|DRUG: Placebo for BTDS patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Rituximab Plus Zanubrutinib and Lenalidomide for Relapsed and Refractory Diffuse Large B Cell Lymphoma, a Multicenter, Open and Prospective Clinical Trial
Status: UNKNOWN
Conditions: Overall Survival
Interventions: DRUG: Rituximab + zanubrutinib + lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Text Message Intervention for Prevention of Cardiovascular Disease in Primary Care Patients With Hypertension
Status: COMPLETED
Conditions: Hypertension|Cardiovascular Risk Factor
Interventions: BEHAVIORAL: SMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improved Intra-operative Safety From Optimal Selection of Anti-slip Surface
Status: COMPLETED
Conditions: Vaginal Surgery|Laparoscopic Surgery
Interventions: DEVICE: Pink Pad|DEVICE: Bean Bag|DEVICE: Gel Pad
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioequivalence Study of Cefprozil 250 mg/ 5mL Powder For Oral Suspension Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CEFPROZIL FOR ORAL SUSPENSION USP 250 mg/ 5 mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose:
Clinical trial: How Parents Can Help Babies Learn to Talk With Picture Books.
Status: COMPLETED
Conditions: Language Development
Interventions: BEHAVIORAL: Contingent Reading Intervention|BEHAVIORAL: Book Provision Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Long-term Efficacy and Safety Study of Tramadol Hydrochloride Plus Acetaminophen (JNS013) in Japanese Participants With Chronic Pain
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DRUG: Tramadol Hydrochloride (HCL) plus Acetaminophen (JNS013)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PD-1 Monoclonal Antibody Combined With FLOT Regimen for Neoadjuvant Therapy of Gastric Adenocarcinoma
Status: UNKNOWN
Conditions: Gastric and Esophagogastric Junction Adenocarcinoma
Interventions: DRUG: PD-1 Monoclonal Antibody(Sintilimab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID-19
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronavirus Infections|Pneumonia, Viral|Acute Respiratory Distress Syndrome
Interventions: DRUG: Nitric Oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SmartTouch Catheter for Left Anterior Line - SmarT Line Study
Status: COMPLETED
Conditions: Persistent Atrial Fibrillation
Interventions: DEVICE: Thermocool Smart Touch Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Desmopressin for Bleeding Related to Low Body Temperature
Status: UNKNOWN
Conditions: Hypothermia Induced Impairment of Primary Haemostasis
Interventions: DRUG: desmopressin|DRUG: desmopressin|DRUG: desmopressin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Retrospective Study to Evaluate the ConforMIS iUni, iDuo & iTotal® KRS
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Knee Osteoarthritis
Interventions: DEVICE: ConforMIS iUni, iDuo, or iTotal (CR)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TRILUMINATE Study With Abbott Transcatheter Clip Repair System in Patients With Moderate or Greater TR
Status: ACTIVE_NOT_RECRUITING
Conditions: Tricuspid Valve Insufficiency
Interventions: DEVICE: Tricuspid Valve Repair System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stroke and CPAP Outcome Study: A Sham-controlled Trial of CPAP Among Stroke Rehabilitation Patients
Status: COMPLETED
Conditions: Stroke|Sleep Apnea, Obstructive
Interventions: DEVICE: Auto-titrating CPAP|DEVICE: Sham-CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving the Safety of Fluoropyrimidine-based Chemotherapy
Status: UNKNOWN
Conditions: Neoplasms
Interventions: DRUG: Fluoropyrimidine (capecitabine or 5-fluorouracil)|DRUG: Fluoropyrimidine (capecitabine or 5-fluorouracil)|DRUG: Fluoropyrimidine (capecitabine or 5-fluorouracil)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MRG002 in the Treatment of Patients With HER2-expressed Advanced Malignant Solid Tumors.
Status: RECRUITING
Conditions: Advanced Malignant Solid Tumors
Interventions: DRUG: MRG002+HX008
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label, Single-Arm Study to Evaluate the Safety and Rabies Virus Antibody Titers of Intramuscularly Administered Rabies Immune Globulin (Human)
Status: COMPLETED
Conditions: Rabies
Interventions: BIOLOGICAL: RIG-C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial in Adult Subjects With Acute Migraines
Status: COMPLETED
Conditions: Migraine, With or Without Aura
Interventions: DRUG: Rimegepant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness Study "HospiAvontuur":
Status: UNKNOWN
Conditions: Children|Preoperative Anxiety|Surgery
Interventions: DEVICE: HospiAvontuur|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Outcomes of Open Versus Robotic-assisted Laparoscopic Posterior Component Separation in Complex Abdominal Wall Repair
Status: COMPLETED
Conditions: Abdominal Wall Hernia
Interventions: PROCEDURE: Robotic tranversus abdominis release operation|PROCEDURE: Open transversus abdominis release operation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Early Gastric Decompression During Advanced Cardiopulmonary Resuscitation (EGD_ACLS)
Status: COMPLETED
Conditions: Out-of-Hospital Cardiac Arrest
Interventions: PROCEDURE: Gastric decompression
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma
Status: RECRUITING
Conditions: Low Grade Glioma|Neurofibromatosis Type 1|Visual Pathway Glioma
Interventions: DRUG: Carboplatin|PROCEDURE: Magnetic Resonance Imaging|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|DRUG: Selumetinib Sulfate|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effects of Daily Consumption of Blueberry (Poly)Phenols on Vascular Function and Cognitive Performance
Status: COMPLETED
Conditions: Healthy Aging|Healthy
Interventions: DIETARY_SUPPLEMENT: Wild Blueberry powder|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Magnetic Gastro-Ileal or Gastro-Jejunal Diversion Study ("MGI/MGJ Study")
Status: RECRUITING
Conditions: Obesity|Type 2 Diabetes
Interventions: DEVICE: MagGJ System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Versatility of a Circular Multielectrode Catheter in the Individualized Recognition & Treatment of Atrial Fibrillation and Related Arrhythmias Using Pulsed Field Energy
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation, Paroxysmal or Persistent|Atrial Fibrillation and Flutter|Atrial Flutter Typical
Interventions: DEVICE: VARIPULSE™ catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prebiotic Galacto-oligosaccharide and Acute GVHD
Status: RECRUITING
Conditions: Acute GVHD
Interventions: DIETARY_SUPPLEMENT: Galacto-oligosaccharide|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Early Continuous Renal Replacement Therapies (CRRT) in Patients With Severe Sepsis or Septic Shock With Acute Kidney Injury
Status: UNKNOWN
Conditions: Severe Sepsis|Septic Shock|Acute Kidney Injury
Interventions: PROCEDURE: crrt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proactive and Integrated Management and Empowerment in Parkinson's Disease (PRIME-UK): A New Model of Care (PRIME-RCT)
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinsonism
Interventions: OTHER: PRIME Parkinson Care|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Single-Center Prospective Study to Investigate the Difference in the Incidence of Contrast-Induced Nephropathy in High-Risk Patients With the Use of the Dye-Vert Plus System
Status: UNKNOWN
Conditions: AKI (Acute Kidney Injury) Due to Trauma
Interventions: DEVICE: DyeVert Plus System|OTHER: Standardized hydration protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intramuscular Ephedrine in the Prevention of Hypotension in Patients Undergoing Spinal Anesthesia
Status: UNKNOWN
Conditions: Ephedrine|Intramuscular|Hypotension|Spinal Anesthesia
Interventions: DRUG: Intramuscular ephedrine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dietary and Exercise Interventions in Reducing Side Effects in Patients With Stage I-IIIa Breast Cancer Receiving Aromatase Inhibitors
Status: ACTIVE_NOT_RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Arthralgia|Postmenopausal|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8
Interventions: DIETARY_SUPPLEMENT: Dietary Intervention|BEHAVIORAL: Exercise Intervention|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Anesthetics and Cerebral Oxygenation in LSG
Status: COMPLETED
Conditions: Morbid Obesity|Bariatric Surgery Candidate|Anesthesia
Interventions: DRUG: Inhalational anesthetic|DRUG: Intravenous anesthetic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Proof of Concept Study to Assess the Efficacy, Safety of HRS-5965 in Patients With Paroxysmal Nocturnal Hemoglobinuria
Status: ACTIVE_NOT_RECRUITING
Conditions: Paroxysmal Nocturnal Hemoglobinuria
Interventions: DRUG: HRS-5965 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Assess the Effect of Vildagliptin on Postprandial Lipid Parameters in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib in Combination With Trastuzumab Deruxtecan or With Trastuzumab Emtansine and to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
Status: RECRUITING
Conditions: Metastatic Breast Cancer|Metastatic Gastric Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma|Esophageal Adenocarcinoma
Interventions: DRUG: Zongertinib|DRUG: Trastuzumab deruxtecan|DRUG: Trastuzumab emtansine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigational Device Exemption (IDE) Study for the Approval of Closed Loop Stimulation (CLS) and Cardiac Resyncronization Pacing Therapies (CRT) for the Treatment of Atrial Fibrillation (AF) With Ablate and Pace
Status: TERMINATED
Conditions: Atrial Fibrillation|Congestive Heart Failure
Interventions: DEVICE: Protos DR/CLS and Stratos LV CRT pacemakers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Therapy of GP Chemotherapy Combined With Tislelizumab in Locoregionally Advanced NPC
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: GP combine with Tislelizumab neoadjuvant therapy+CCRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EARLYdrain - Outcome After Early Lumbar CSF-drainage in Aneurysmal SAH
Status: COMPLETED
Conditions: Aneurysmal Subarachnoid Hemorrhage
Interventions: PROCEDURE: Insertion of a lumbar drain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study of Xilonix in Patients With Advanced Colorectal Cancer
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Xilonix|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnesium Replacement and Hyperglycemia After Kidney Transplantation
Status: UNKNOWN
Conditions: Hypomagnesemia|Kidney Transplantation
Interventions: DRUG: Mablet 360 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Nasal and Oropharyngeal Bleeding in Video Laryngoscopy and Direct Laryngoscopy for Nasal Intubation
Status: RECRUITING
Conditions: Maxillofacial Injuries|Nasal Bleeding|Intubation Complication
Interventions: PROCEDURE: Combined Video Laryngoscopy (VL) and Bougie|PROCEDURE: Combined Direct Laryngoscopy (DL) and Bougie
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Percutaneous Pulley Release With Infiltration, Versus Infiltration Alone in Trigger Finders
Status: RECRUITING
Conditions: Trigger Finger
Interventions: PROCEDURE: Percutaneous A1 Pulley Release Under Ultrasound Guidance|DRUG: Corticosteroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comeback From Long coursE Androgen Deprivation Therapy (ADT) With RElugolix and Darolutamide (CLEARED)
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer|Advanced Prostate Cancer|Hormone Sensitive Prostate Cancer
Interventions: DRUG: Darolutamide|DRUG: Relugolix
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Combined Lidocaine - Chlorprocaine in Labor Epidural Analgesia.
Status: NOT_YET_RECRUITING
Conditions: Labor Pain
Interventions: DRUG: Chlorprocaine|DRUG: Lidocaine|DRUG: Lidocaine-chlorprocaine combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Intraoperative Remifentanil Infusion Rate on Postoperative Tolerance and Analgesic Consumption in Pediatric Laparoscopic Ureteroneocystostomy
Status: UNKNOWN
Conditions: Pediatrics
Interventions: DRUG: remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose:
Clinical trial: Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy Treatment (Capecitabine) During Radiation Therapy for Rectal Cancer
Status: TERMINATED
Conditions: Locally Advanced Rectal Carcinoma|Rectal Adenocarcinoma|Stage II Rectal Cancer AJCC v8|Stage III Rectal Cancer AJCC v8
Interventions: DRUG: Capecitabine|RADIATION: Radiation Therapy|DRUG: Ropidoxuridine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Efficacy and Safety of ABT-493/ABT-530 to Sofosbuvir Dosed With Daclatasvir in Adults With HCV Genotype 3 Infection
Status: COMPLETED
Conditions: Chronic Hepatitis C|Hepatitis C Virus|Genotype 3 Hepatitis C Virus
Interventions: DRUG: ABT-493/ABT-530|DRUG: Sofosbuvir|DRUG: Daclatasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarker Exploration in Aging, Cognition and Neurodegeneration
Status: RECRUITING
Conditions: Alzheimer Disease|Cognitive Impairment|Cognitive Decline
Interventions: RADIATION: Amyloid PET scan|DRUG: Tau PET scan using MK-6240|BEHAVIORAL: Neurocognitive testing|OTHER: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study Assessing Safety and Efficiency of the Lenalidomide and Dexamethasone Combination in Patients With Chronic Lymphatic Leukemia (CLL) Relapsing or Resistant to Treatment
Status: COMPLETED
Conditions: Chronic Lymphatic Leukemia
Interventions: DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Serum Levels of C Reactive Protein (CRP) and Its Correlation With Fetal Ultrasound Parameters in the Prediction of Threatened Miscarriage in the First Trimester
Status: COMPLETED
Conditions: Threatened Miscarriage
Interventions: DIAGNOSTIC_TEST: Serum C reactive protein (CRP) level|DIAGNOSTIC_TEST: Ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Menactra® in US Adolescents When Administered Concomitantly With Tdap Vaccine
Status: COMPLETED
Conditions: Meningitis|Meningococcemia|Pertussis|Tetanus|Diphtheria
Interventions: BIOLOGICAL: T dap + Meningococcal Polysaccharide Diphtheria Toxoid Conj.|BIOLOGICAL: Tdap + Meningococcal Polysaccharide Diphtheria Toxoid Conj.|BIOLOGICAL: Meningococcal Polysaccharide Diphtheria Toxoid Conj. + T dap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Preventing Extension of Oligoarticular Juvenile Idiopathic Arthritis JIA (Limit-JIA)
Status: ACTIVE_NOT_RECRUITING
Conditions: Juvenile Idiopathic Arthritis
Interventions: DRUG: Abatacept Injection|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Progression of Active Microcavitated Carious Lesions on Primary Molar Occlusal Surfaces
Status: COMPLETED
Conditions: Dental Caries in Children|Pit and Fissure Sealant|Toothbrushing
Interventions: PROCEDURE: 1450 ppm fluoride toothpaste brushing x Resin sealing (FluroShield, Dentsply, Brazil).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physiotherapist Supervised Training in Patients With Anterior Shoulder Instability
Status: RECRUITING
Conditions: Shoulder Instability Subluxation Bilateral
Interventions: BEHAVIORAL: Physiotherapist supervised training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Avelumab With Valproic Acid in Virus-associated Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer That is Associated With a Chronic Viral Infection|p16 Positive SCCHN|Squamous Cell Carcinoma of the Cervix|p16 Positive Squamous Cell Carcinoma of the Vagina or Vulva|p16 Positive Squamous Cell Carcinoma of the Penis|p16 Positive Squamous Cell Carcinoma of the Anus or Anal Canal|EBER Positive NPC|EBER Positive Hodgkins and Non-hodgkins Lymphona
Interventions: DRUG: Valproic Acid|BIOLOGICAL: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-man Single-dose and Multiple Dose Study to Evaluate the Safety, Tolerability and Efficacy ofHY-133
Status: NOT_YET_RECRUITING
Conditions: Staphylococcus Aureus
Interventions: DRUG: HY_133|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Perioperative Nitric Oxide Prevents Acute Kidney Injury in Cardiac Surgery Patients With Chronic Kidney Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Kidney Disease|Chronic Kidney Disease|Cardiac Surgery|Cardiopulmonary Bypass
Interventions: DRUG: Sham treatment|DRUG: 80-ppm NO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 2 Study of BIIB092 in Participants With Early Alzheimer's Disease
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: BIIB092|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FAPO-X: Assisted Digital Telemonitoring With Wearables in Patients After Cardiovascular Surgery
Status: COMPLETED
Conditions: Heart; Surgery, Heart, Functional Disturbance as Result
Interventions: DEVICE: Wearable: Smartwatch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Acetylcysteine With Topotecan Hydrochloride on the Tumor Microenvironment in Patients With Persistent or Recurrent High Grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
Status: TERMINATED
Conditions: Malignant Ovarian Endometrioid Tumor|Malignant Ovarian Serous Tumor|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma
Interventions: DRUG: Topotecan Hydrochloride|DRUG: Topotecan Hydrochloride|DRUG: Acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the The Neuromodulation System for the Treatment of Overactive Bladder Symptoms
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DEVICE: Non-invasive low-frequency tibial nerve stimulator (TNS-01)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Trial of Tivantinib With FOLFOX for the Treatment of Advanced Solid Tumors and Previously Untreated Metastatic Adenocarcinoma of the Distal Esophagus, Gastroesophageal Junction or Stomach
Status: COMPLETED
Conditions: Malignant Solid Tumour|Gastroesophageal Cancer
Interventions: DRUG: Tivantinib|DRUG: FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Oral Lactobacilli on Vaginal Flora of Pregnant Women
Status: COMPLETED
Conditions: Bacterial Vaginosis
Interventions: BIOLOGICAL: Lactobacilli rhamnosus GR-1 and Lactobacilli fermentum RC-14|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Vasopressin Versus Terlipressin as a Second Vasopressor in Critically Ill Cirrhotics With Septic Shock- the VITEL-C Trial
Status: UNKNOWN
Conditions: Septic Shock|Cirrhosis, Liver
Interventions: DRUG: Terlipressin|DRUG: vasopressin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT