pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Final Oocyte Maturation Via Administration of GnRH Agonists Followed By Luteal Support With hCG
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: TRIPTORELIN ACETATE, hCG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Infiltration Analgesia Following Unicompartmental Knee Arthroplasty
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: ropivacaine, ketorelac and epinephrine|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ciprofol Sedation in Patients Undergoing Liver Cancer Percutaneous Radiofrequency Ablation
Status: RECRUITING
Conditions: Liver Cancer|Ciprofol
Interventions: DRUG: Propofol|DRUG: Ciprofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of KW-6002 (Istradefylline) for the Treatment of Parkinson's Disease in Patients Taking Levodopa
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Istradefylline|DRUG: Istradefylline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Discovery of Biological Signatures for Cruciferous Vegetable Intake (Single Serving)
Status: ACTIVE_NOT_RECRUITING
Conditions: Diet, Healthy
Interventions: OTHER: Broccoli sprouts|OTHER: Deuterium oxide-labelled broccoli sprouts|OTHER: Alfalfa sprouts|OTHER: Deuterium oxide-labelled alfalfa sprouts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Single-center Phase II Study to Investigate the Immune Maintenance Therapy Pattern in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Who Have Achieved MPR After Neoadjuvant Immunotherapy Combined With Chemotherapy
Status: RECRUITING
Conditions: Head and Neck Cancer
Interventions: DRUG: Toripalimab|RADIATION: Radiation Therapy|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation Of GW815SF For Chronic Obstructive Pulmonary Disease (Chronic Bronchitis, Emphysema)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: fluticasone propionate/salmeterol combination DISKUS|DRUG: salmeterol xinafoate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sodium Awareness in Lactation Trial
Status: NOT_YET_RECRUITING
Conditions: Breastfeeding|Preterm Birth|Breast Pumping|Lactation; Insufficient, Partial
Interventions: DIAGNOSTIC_TEST: point-of-care milk sodium testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Mask Ventilation Techniques in Patients Requiring General Anesthesia
Status: COMPLETED
Conditions: Apnea
Interventions: PROCEDURE: V-E mask ventilation for one minute|PROCEDURE: C-E mask ventilation for one minute
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiological Responses to Osteopathic Manipulative Techniques in Healthy Young Adults
Status: COMPLETED
Conditions: Healthy Young Adults
Interventions: PROCEDURE: Cranial manipulation group, or cranial osteopathic techniques (OMM)|PROCEDURE: Sham manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Low-Energy Ultrasound, Electrical and Magnetic Field Stimulation in Therapy-Resistant Myofascial Pain Syndrome
Status: RECRUITING
Conditions: Myofascial Pain Syndrome - Lower Back|Myofascial Pain Syndrome - Neck|Myofascial Pain Syndrome - Tension Headache
Interventions: DEVICE: Active Sonodyn|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Retrospective Data Collection Study in Patients Receiving Two or More OZURDEX® Injections for Macular Oedema Secondary to Retinal Vein Occlusion
Status: COMPLETED
Conditions: Retinal Vein Occlusion|Macular Oedema
Interventions: DRUG: dexamethasone intravitreal implant 0.7 mg
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Multiple Dose Study Of PF-04620110 In Overweight And Obese, Otherwise Healthy Volunteers
Status: COMPLETED
Conditions: Obesity|Overweight|Healthy
Interventions: DRUG: PF-04620110|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Modified BPaL Regimen for Managing Pre-XDR TB and MDR (TI/NR) TB in India
Status: ACTIVE_NOT_RECRUITING
Conditions: Pre-Extensively Drug-Resistant Pulmonary TB|Treatment Intolerant Multidrug-Resistant Pulmonary TB|Non-responsive Multidrug-Resistant Pulmonary TB
Interventions: DRUG: Linezolid|DRUG: Bedaquiline|DRUG: Pretomanid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of SM04646 Inhalation Solution in Subjects With Idiopathic Pulmonary Fibrosis (IPF)
Status: WITHDRAWN
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: SM04646
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Immunogenicity of One or Two Booster Vaccinations With H5N6 Influenza Vaccine in Adults Primed With H5N1 Influenza Vaccine or Unprimed
Status: COMPLETED
Conditions: Influenza, Human|Influenza in Birds|Respiratory Tract Infections|Infections|Orthomyxoviridae Infections|RNA Virus Infections|Virus Diseases|Respiratory Tract Diseases
Interventions: BIOLOGICAL: aH5N6c on Day 1|BIOLOGICAL: aH5N6c on Day 22|BIOLOGICAL: Placebo on Day 22
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial of Freeze-dried Human Rabies Vaccine (Without Serum Vero Cells)
Status: NOT_YET_RECRUITING
Conditions: Rabies
Interventions: BIOLOGICAL: 5-dose group of test vaccine|BIOLOGICAL: 5-dose group of control vaccine|BIOLOGICAL: 4-dose A group of test vaccine|BIOLOGICAL: 4-dose B group of test vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: EPO-4-Rhesus Study
Status: UNKNOWN
Conditions: Erythroblastosis, Fetal|Erythroblastosis Fetalis, Rh Disease|Erythroblastosis Fetalis Due to RH Antibodies|Erythroblastosis Fetalis Due to Isoimmunization
Interventions: DRUG: Darbepoetin Alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 89Zr-atezolizumab PET Scan and Lobular Breast Cancer
Status: TERMINATED
Conditions: Lobular Metastatic Breast Cancer
Interventions: OTHER: 89Zr-atezolizumab PET scans
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study to Assess the Safety and Efficacy of TD-1211 in Subjects With Opioid-Induced Constipation
Status: COMPLETED
Conditions: Opioid Induced Constipation
Interventions: DRUG: TD-1211|DRUG: TD-1211|DRUG: TD-1211|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Granisetron Versus Metoclopramide Effects on Gastric Volume by Sonographic Assessment on Patients Undergoing Caesarean Section.
Status: UNKNOWN
Conditions: Aspiration Vomitus
Interventions: DRUG: metoclopramide versus granisetron
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRI-based Signatures for Survival Prediction in Cervical Cancer With Radiotherapy
Status: NOT_YET_RECRUITING
Conditions: Cervical Cancer|Radiotherapy|Prognostic Model|MRI
Interventions: RADIATION: Treatment mainly composed of external pelvic beam radiotherapy (EBRT) followed by individualized high-dose-rate intracavitary brachytherapy (HDR-ICBT) .
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Durvalumab in Combination With Lenalidomide With and Without Dexamethasone in Adults With Newly Diagnosed Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Durvalumab|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II, Open Label, Single Arm, Multicenter Study of Chlorambucil in Japanese Previously Untreated Patients With Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukaemia, Lymphoblastic
Interventions: DRUG: chlorambucil, tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib, Cetuximab, and Radiation Therapy With or Without Cisplatin in Treating Patients With Stage IV Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: bortezomib|DRUG: cisplatin|RADIATION: intensity-modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Spinal Manipulation With Laser Therapy Versus Dry Needling in Chronic Lower Backache
Status: RECRUITING
Conditions: Low Back Pain
Interventions: DIAGNOSTIC_TEST: Spinal Manipulation With Laser Therapy|DIAGNOSTIC_TEST: Dry Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety of Low Dose IV Contrast CT Scanning in Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease|Pulmonary Embolism|Renal Artery Stenosis|Pulmonary Cancer
Interventions: DRUG: Low Volume iso-osmolar non-ionic radio contrast medium|DRUG: Acetylcysteine Inhalation|DRUG: Sodium Bicarbonate Solution|PROCEDURE: 64-MDCT Scanning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Adoptive Transfer Of Autologous Tumor-Infiltrating Lymphocytes in Solid Tumors
Status: TERMINATED
Conditions: Solid Tumor, Adult
Interventions: OTHER: TIL|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Interleukin-2|OTHER: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Dexmedetomidine Administered Intranasally to Relieve Perioperative Anxiety and Depression in Patients With Colorectal Tumors
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: Dexmedetomidine administered intranasally
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Intraventricule Pemetrexed Disodium Administered Via Ommaya Reservoir
Status: RECRUITING
Conditions: Leptomeningeal Metastasis|Lung Cancer
Interventions: DRUG: Pemetrexed injection|DRUG: Pemetrexed
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Alemtuzumab/Fludarabine for Relapsed/Refractory B-cell Chronic Lymphocytic Leukemia (B-CLL)
Status: COMPLETED
Conditions: Leukemia, Lymphocytic, Chronic, B-Cell
Interventions: DRUG: Alemtuzumab plus Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intranasal Oxytocin and Learning in Autism
Status: COMPLETED
Conditions: Autism Spectrum Disorders
Interventions: DRUG: Intranasal Oxytocin (Trade name: Syntocinon)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perfusion CT as a Predictor of Treatment Response in Patients With Hepatic Malignancies
Status: TERMINATED
Conditions: Neuroendocrine Tumors|Brain (Nervous System) Cancers|Colon/Rectal Cancer|Colon Cancer|Hepatobiliary Cancers|Hepatocellular Carcinoma (Hepatoma)|Liver
Interventions: PROCEDURE: CT perfusion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PROtocol for Coxsackievirus VaccinE in Healthy VoluNTteers
Status: COMPLETED
Conditions: Viral; Infection, Coxsackie(Virus)
Interventions: BIOLOGICAL: PRV-101|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study CB-839 in Combination With Nivolumab in Patients With Melanoma, Clear Cell Renal Cell Carcinoma (ccRCC) and Non-Small Cell Lung Cancer (NSCLC)
Status: TERMINATED
Conditions: Clear Cell Renal Cell Carcinoma (ccRCC)|Melanoma|Non-small Cell Lung Cancer (NSCLC)
Interventions: DRUG: CB-839|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Collection of Specimens of the Lower Respiratory Tract
Status: COMPLETED
Conditions: Respiratory Tract Infections
Interventions: PROCEDURE: Forced expiratory technique and induced sputum|PROCEDURE: Tracheal suction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Drug Interaction Study With a Potential Alzheimer's Disease Compound
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Interacting drugs - Cooperstown Cocktail (midazolam, warfarin, (+ vitamin K), caffeine, omeprazole and dextromethorphan)|DRUG: BMS-708163|DRUG: BMS-708163 + Cooperstown Cocktail
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Quality of Life by Improved Patient Expectation Following Atrial Fibrillation Catheter Ablation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: OTHER: Expectation optimization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Activity Breaks for Brain Health in Adolescents
Status: COMPLETED
Conditions: Healthy Adolescents
Interventions: BEHAVIORAL: Prolonged sitting (social breaks)|BEHAVIORAL: Prolonged sitting with step-up exercise break|BEHAVIORAL: Prolonged sitting with simple resistance activity breaks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Family-Centered Intervention for Preterm Children: Effects at School Age and Biosocial Mediators
Status: COMPLETED
Conditions: Premature Birth
Interventions: OTHER: Family-centered intervention program (FCIP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Sterile Amniotic Fluid Filtrate Epidural Injection.
Status: RECRUITING
Conditions: Lumbar Spinal Stenosis
Interventions: DRUG: Amniotic Fluid Allograft|DRUG: Dexamethasone sodium phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of The Success Rates of Four Different Pulpotomy Techniques
Status: COMPLETED
Conditions: Extensive Decay in Primary Molars
Interventions: DRUG: Biodentine|DRUG: ProRoot (Aggregate)|DRUG: MTA Plus|DRUG: Ferric Sulfate 20 % Dental Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Observation on the Efficacy and Safety of Pulsed Dye Laser (PDL) in the Treatment of Nail Psoriasis
Status: COMPLETED
Conditions: Nail Psoriasis
Interventions: DRUG: Halometasone Cream|DRUG: Vaseline|RADIATION: Pulsed dye laser (PDL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Genotype-guided Warfarin Individualized Treatment
Status: COMPLETED
Conditions: Atrial Fibrillation|Deep Venous Thrombosis
Interventions: BEHAVIORAL: Genotype-guided dosing algorithm for warfarin|BEHAVIORAL: Standard initiation dose for warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of SYSTANE® BALANCE in Dry Eye Subjects With Lipid Deficiency
Status: COMPLETED
Conditions: Dry Eye Syndrome|Lipid Deficiency
Interventions: OTHER: SYSTANE® BALANCE eyedrops|OTHER: Minims® Saline 0.9% eyedrops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing BL-B01D1 With Topotecan in Patients With Recurrent Small Cell Lung Cancer
Status: RECRUITING
Conditions: Small Cell Lung Cancer
Interventions: DRUG: BL-B01D1|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Azithromycin and Cefixime Treatment of Typhoid in South Asia Trial (ACT-South Asia Trial)
Status: RECRUITING
Conditions: Typhoid Fever
Interventions: DRUG: Azithromycin|DRUG: Cefixime|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of CHS-1000 in Participants With Advanced or Metastatic Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced or Metastatic Solid Tumors
Interventions: BIOLOGICAL: CHS-1000|BIOLOGICAL: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Avelumab in Patients With Advanced Hepatocellular Carcinoma After Prior Sorafenib Treatment
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Accuracy of Saline Sonohystrography vs. 3D Transvaginal Ultrasound for Cesarean Scar Defect Assessment
Status: NOT_YET_RECRUITING
Conditions: Cesarean Scar Defects|Cesarean Section Complications|Uterine Scar Dehiscence|Vaginal Birth After Cesarean|Abnormal Uterine Bleeding
Interventions: DIAGNOSTIC_TEST: Three-Dimensional Transvaginal Ultrasound (3D TVS)|DIAGNOSTIC_TEST: Saline-Infused Sonography (Sonohystrography)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Assess Adverse Events and Compare How Two Subcutaneous ABBV-154 Injection Formulations Move Through the Body of Adult Healthy Participants
Status: COMPLETED
Conditions: ABBV-154
Interventions: DRUG: ABBV-154 Dose Formulation A|DRUG: ABBV-154 Dose Formulation B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of the Prophylactic Use of Doxycycline +/- Vitamin K Cream
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DEVICE: Reconval K1 Cream|DEVICE: Reconval Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Periorbital Rejuvenation With a 1927 nm Diode Laser Treatment
Status: UNKNOWN
Conditions: Laser|Periorbital
Interventions: DEVICE: Periorbital rejuvenation with a 1927 nm diode laser treatment (2-week interval)|DEVICE: Periorbital rejuvenation with a 1927 nm diode laser treatment (4-week interval)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy of Two Therapeutic Strategies for Cervical Maturation Before Medical Termination
Status: COMPLETED
Conditions: Medical; Abortion, Fetus
Interventions: PROCEDURE: Mifepristone + Misoprostol OR oxytocine + laminaria|PROCEDURE: Mifepristone + Misoprostol OR oxytocine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: the Mini-plate Anchored Herbst Appliance Versus the Dentally Anchored Fixed Functional Appliance
Status: COMPLETED
Conditions: Class II Malocclusion
Interventions: PROCEDURE: Herbst Group|DEVICE: TFBC Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Combination Effect of Dexmedetomidine and Morphine in Postoperative Patient-Controlled Analgesia
Status: COMPLETED
Conditions: Analgesia, Patient-Controlled|Analgesia, Postoperative
Interventions: DRUG: dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Microvascular Function in Patients Undergoing Transcatheter Aortic Valve Implant (TAVI) for Severe Symptomatic Aortic Stenosis: Association With Myocardial Fibrosis
Status: RECRUITING
Conditions: Severe Symptomatic Aortic Stenosis
Interventions: DEVICE: coronary physiology
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effectiveness and Safety of Synvisc® Versus Usual Treatments in Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Hylan G-F 20|DRUG: Standard treatment|PROCEDURE: Physiotherapy|PROCEDURE: Hydrotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Evaluating Paliperidone Extended-Release (ER) Tablets Versus Placebo on Sleep in Schizophrenia Patients
Status: COMPLETED
Conditions: Schizophrenia|Insomnia
Interventions: DRUG: paliperidone ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Nasal Provocation Test With Lysine-Acetylsalicylate (ASA) in Patients With Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Hypersensitivity
Status: COMPLETED
Conditions: Aspirin Hypersensitivity|NSAIDs Hypersensitivity
Interventions: PROCEDURE: Lysine-ASA Nasal ProvocationTest
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Promoting BEST (BEtter, Faster, Longer, STronger) Walking for People With Parkinson's
Status: ENROLLING_BY_INVITATION
Conditions: Parkinson Disease
Interventions: DEVICE: Heel2Toe[TM] sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial to Assess Efficacy and Safety of Continuous Glucose Monitoring in Children 4-<10 Years With T1DM
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DEVICE: Continuous glucose monitor|DEVICE: Home blood glucose monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Trial Comparing Efficacy and Safety of Dabigatran Etexilate With Warfarin in Patients With Cerebral Venous and Dural Sinus Thrombosis (RE-SPECT CVT)
Status: COMPLETED
Conditions: Thromboembolism
Interventions: DRUG: Dabigatran etexilate|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Autologous Concentrated Bone Marrow Aspirate in Preventing Wound Complications in Below Knee Amputation (BKA)
Status: COMPLETED
Conditions: Peripheral Artery Disease|Vascular Disease|Critical Limb Ischemia
Interventions: BIOLOGICAL: Injection of cBMA aspirate into the index leg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pioglitazone as Second-Line in Patients With Metastatic Pancreatic Cancer After Treatment With Gemcitabine
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: pioglitazone hydrochloride|OTHER: laboratory biomarker analysis|OTHER: questionnaire administration|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Systematic Nursing Orientations in the Reduction of Predicted Cardiovascular Risk in Patients With Coronary Artery Disease.
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: BEHAVIORAL: Systematic education in the reduction of the risk estimate to cardiovascular events
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cord Blood With T-Cell Depleted Haplo-identical Peripheral Blood Stem Cell Transplantation for Hematological Malignancies
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndrome|Lymphoma
Interventions: DEVICE: CliniMACS Fractionation system (Arm A)|DEVICE: CliniMACS Fractionation system (Arm B)|BIOLOGICAL: Haploidentical donor CD34+ cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT on NPWT for Incisions Following Major Lower-limb Amputation to Reduce Surgical Site Infection
Status: UNKNOWN
Conditions: Amputation Wound|Amputation Stump Complication|Amputation Stump; Infection|Infection
Interventions: DEVICE: Negative pressure wound therapy|OTHER: Standard dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide|DRUG: Placebo (semaglutide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PK, PD, Safety, and Efficacy of SAIT101 Versus MabThera® Versus Rituxan® in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: SAIT101|BIOLOGICAL: MabThera|BIOLOGICAL: Rituxan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pioglitazone in Impaired Glucose Tolerance
Status: WITHDRAWN
Conditions: Glucose Metabolism Disorders
Interventions: DRUG: pioglitazone|DRUG: simvastatin|DRUG: pioglitazone + simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of KW-0761 in Subjects With HTLV-1 Associated Myelopathy (HAM)
Status: TERMINATED
Conditions: HTLV-1 Associated Myelopathy
Interventions: DRUG: KW-0761 0.3 mg/kg IV|DRUG: Placebo (saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lentivirally Redirected CD123 Autologous T Cells in AML
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia, in Relapse|Acute Myeloid Leukemia, Adult|Acute Myeloid Leukemia, Refractory
Interventions: BIOLOGICAL: CART123 cells; cyclophosphamide; fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remission Evaluation of a Metabolic Intervention for Type 2 Diabetes With IGlarLixi
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: iGlarLixi|DRUG: Insulin Glargine|DRUG: Metformin|BEHAVIORAL: Lifestyle therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-Dose Intravenous Inositol Pharmacokinetics in Preterm Infants
Status: COMPLETED
Conditions: Infant, Newborn|Infant, Low Birth Weight|Infant, Small for Gestational Age|Infant, Premature|Retinopathy of Prematurity|Bronchopulmonary Dysplasia (BPD)
Interventions: DRUG: Inositol lower volume|DRUG: Inositol higher volume|DRUG: Placebo lower volume|DRUG: Placebo higher volume
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pure Red Cell Aplasia in Patients With Chronic Kidney Disease and in Use of Epoetin Alfa
Status: UNKNOWN
Conditions: Red-Cell Aplasia, Pure|Renal Insufficiency, Chronic
Interventions: PROCEDURE: Pure Red Cell Aplasia diagnostic confirmation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Video-laryngoscopy During Chest Compression
Status: UNKNOWN
Conditions: Cardiac Arrest|Intubation, Endotracheal
Interventions: DEVICE: CoopDech|DEVICE: CoPilot|DEVICE: Intubrite|DEVICE: Vividtrack
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Angiotensin Converting Enzyme (ACE) Inhibition and Peripheral Arterial Disease
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DRUG: Ramipril or matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effectiveness of Different Machines in Intense Pulsed Light Treatment of Meibomian Gland Dysfunction
Status: COMPLETED
Conditions: MGD-Meibomian Gland Dysfunction
Interventions: PROCEDURE: Intense pulsed light|DRUG: 0.3% hyaluronic acid eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ranolazine on Gastrointestinal Motor Function and Pain in Patients With IBS-D
Status: TERMINATED
Conditions: Diarrhea Predominant Irritable Bowel Syndrome
Interventions: DRUG: Ranolazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability of a Linagliptin+Metformin Fixed Dose Combination Tablet Administered With and Without Food to Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Linagliptin/metformin FDC|OTHER: high-fat, high caloric meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-blind Randomized Controlled Trial in Severe Alcoholic Hepatitis
Status: COMPLETED
Conditions: Alcoholic Hepatitis|Alcoholic Liver Disease
Interventions: DRUG: Pentoxifylline|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immune Related Toxicity and Symptom Burden in Chronic Cancer Survivors With Melanoma Receiving Adjuvant Immunotherapy With Immune Checkpoint Inhibitors
Status: RECRUITING
Conditions: Clinical Stage III Cutaneous Melanoma AJCC v8|Pathologic Stage III Cutaneous Melanoma AJCC v8|Pathologic Stage IIIA Cutaneous Melanoma AJCC v8|Pathologic Stage IIIB Cutaneous Melanoma AJCC v8|Pathologic Stage IIIC Cutaneous Melanoma AJCC v8|Pathologic Stage IIID Cutaneous Melanoma AJCC v8|Melanoma, Stage II|Melanoma Stage IV
Interventions: BEHAVIORAL: Assessment|PROCEDURE: Biospecimen Collection|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Recruitment Maneuvers and Lung Protective Ventilation Strategy in ARDS
Status: RECRUITING
Conditions: ARDS
Interventions: PROCEDURE: RM|PROCEDURE: LPVS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TaTME Versus Open Intersphincteric Resection After Neoadjuvant Concurrent Chemoradiotherapy.
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: PROCEDURE: Open intersphincteric resection|DEVICE: transanal minimally invasive intersphincteric resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Pharmacodynamics of a Novel Pegylated Recombinant Human Granulocyte-Colony Stimulating Factor
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GCPGC, Neulasta, Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PET-MRI for Axillary Staging in Node Negative Breast Cancer Patients
Status: RECRUITING
Conditions: Breast Cancer|Breast Neoplasms|Breast Diseases
Interventions: DIAGNOSTIC_TEST: Dedicated axillary hybrid PET-MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Feasibility Study of Ultrasound Elastography Detecting Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: OTHER: Fleet Enema|DEVICE: Aixplorer® ShearWave Elastography (SWE™)|DIAGNOSTIC_TEST: Pre-surgery Ultrasound|PROCEDURE: Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Effects of Oral NMRA 335140 Versus Placebo in Participants With Major Depressive Disorder
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DRUG: NMRA 335140|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Tenapanor for the Treatment of Pediatric Patients (6 to Less Than 18 Years Old) With IBS-C
Status: ENROLLING_BY_INVITATION
Conditions: Irritable Bowel Syndrome With Constipation (IBS-C)
Interventions: DRUG: Tenapanor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Obinutuzumab and Ibrutinib as Front Line Therapy in Treating Patients With Indolent Non-Hodgkin's Lymphomas
Status: RECRUITING
Conditions: Non-Hodgkin's Lymphoma|Ann Arbor Stage II Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue|Ann Arbor Stage II Follicular Lymphoma|Ann Arbor Stage II Nodal Marginal Zone Lymphoma|Ann Abor Stage III B-Cell Non-Hodgkin Lymphoma|Ann Arbor Stage III Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue|Ann Arbor Stage III Follicular Lymphoma|Ann Arbor Stage III Nodal Marginal Zone Lymphoma|Ann Arbor Stage IV B-Cell Non-Hodgkin Lymphoma|Ann Arbor Stage IV Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue|Ann Arbor Stage IV Follicular Lymphoma|Ann Arbor Stage IV Nodal Marginal Zone Lymphoma|Grade 1 Follicular Lymphoma|Grade 2 Follicular Lymphoma|Grade 3a Follicular Lymphoma|Indolent Non-hodgkin Lymphoma|Stage II Splenic Marginal Zone Lymphoma|Stage III Splenic Marginal Zone Lymphoma|Stage IV Splenic Marginal Zone Lymphoma
Interventions: DRUG: Ibrutinib|BIOLOGICAL: Obinutuzumab|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maternal Reflective Functioning During the Transition to Motherhood
Status: NOT_YET_RECRUITING
Conditions: Pregnancy|Primiparous Women
Interventions: OTHER: Maternal Reflective Function Workshop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Gentamicin Open Tibia Study
Status: RECRUITING
Conditions: Fracture Open Tibia
Interventions: DRUG: Gentamicin|DRUG: normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Determine the Effects of Adding an Experimental Device With Mouthrinse to Oral Care Regimen
Status: COMPLETED
Conditions: Gingivitis
Interventions: DEVICE: Interdental cleaning device with water|DEVICE: Interdental cleaning device with essential-oil mouthrinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Target Antigens Induced by Plasmodium Falciparum Sporozoite Immunization Under Chemoprophylaxis
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: CPS-immunization|BIOLOGICAL: Controlled Human Malaria Infection|DRUG: chloroquine|DRUG: atovaquone/proguanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Using Injectable Platelet-rich Fibrin on Root Surface Closure in Patients With Gingival Recession.
Status: ENROLLING_BY_INVITATION
Conditions: Gingival Recession|Gingival Recession, Localized
Interventions: PROCEDURE: i-PRF application procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of an Anterior Latarjet-type Abutment Operation on Scapular Dyskinesia and the Muscular Stabilization Mechanisms of the Scapula (DyScapLat)
Status: UNKNOWN
Conditions: Latarjet|Scapular Dyskinesis
Interventions: PROCEDURE: Latarjet method|OTHER: Different arms exercices
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Research Study to Compare a New Weekly Insulin, Insulin Icodec Used With DoseGuide App, and Daily Insulins in People With Type 2 Diabetes Who Have Not Used Insulin Before
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin icodec|DRUG: Insulin Glargine 100U/mL|DRUG: Insulin Degludec|DRUG: Insulin Glargine 300U/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of Orvepitant in Subjects With Pruritus Associated With Atopic Dermatitis
Status: WITHDRAWN
Conditions: Pruritus|Atopic Dermatitis
Interventions: DRUG: Orvepitant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Customized Bone Allografts by 3D-printing
Status: ENROLLING_BY_INVITATION
Conditions: Musculoskeletal Deformity|Musculoskeletal Diseases|Musculoskeletal Disorder
Interventions: DEVICE: Planning of multiplanar and/or multifocal osteotomies in children by using VSP, PSIs and customized structural bone allograft|DEVICE: Routine preparation of bone graft according to standard protocols|DEVICE: Preparation of bone graft with virtual bone-matching and GSIs|PROCEDURE: Corrective osteotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: 18F-FDG PET-MRI for Planning and Follow-Up of Patients With Spine Tumors Treated With Spine Stereotactic Radiosurgery
Status: COMPLETED
Conditions: Metastatic Malignant Neoplasm|Metastatic Malignant Neoplasm in the Bone
Interventions: OTHER: Fludeoxyglucose F-18|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of SHR6390 Combined With Famitinib in the Treatment of ER + / HER2- Advanced Breast Cancer
Status: TERMINATED
Conditions: ER+ / HER2- Advanced Breast Cancer
Interventions: DRUG: SHR6390、Famitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Immune Study of 2 Types of GlaxoSmithKline's Varicella Vaccines Given as a 2-doses Course to Healthy Children 12-23 Months of Age.
Status: COMPLETED
Conditions: Chicken-pox Illness (Varicella Virus Disease)|Chickenpox
Interventions: BIOLOGICAL: Varilrix HSA-free|BIOLOGICAL: Varilrix™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II Trial to Evaluate an EBV-derived Dendritic Cell Vaccine in Autologous Stem Cell Transplant
Status: WITHDRAWN
Conditions: Hodgkin Lymphoma|Non-Hodgkin Lymphoma
Interventions: BIOLOGICAL: LMP2A-loaded conventional DC vaccine|BIOLOGICAL: DUK-CPG-001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Response Study of a Fermented Yogurt on the Immune System and Gut Health
Status: COMPLETED
Conditions: Immune System
Interventions: DIETARY_SUPPLEMENT: Yogurt with 1X10E9 BB-12 and LA-5|DIETARY_SUPPLEMENT: Yogurt with 1X10E10 BB-12 and LA-5|DIETARY_SUPPLEMENT: Yogurt Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Multicenter Trial to Identify Optimal Atezolizumab Biomarkers in the Setting of Recurrent Glioblastoma. The MOAB Trial
Status: RECRUITING
Conditions: Recurrent Glioblastoma
Interventions: DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study and Therapeutic Effects of Umbilical Cord Blood Treg on Autoimmune Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1
Interventions: BIOLOGICAL: Umbilical Cord Blood Regulatory T cells Therapy|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antineoplaston Therapy in Treating Patients With Neurofibroma and Schwannoma
Status: TERMINATED
Conditions: CNS Tumor
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Combination Treatment of Fimasartan/Atorvastatin in Patients With Essential Hypertension and Dyslipidemia
Status: COMPLETED
Conditions: Essential Hypertension, Dyslipidemia
Interventions: DRUG: Fimasartan 120mg|DRUG: Atorvastatin 40mg|DRUG: Placebo for Fimasartan 120mg|DRUG: Placebo for Atorvastatin 40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of APS001F With Flucytosine and Maltose in Solid Tumors
Status: SUSPENDED
Conditions: Tumors|Neoplasms|Cancer
Interventions: DRUG: APS001F|DRUG: Flucytosine (5-FC)|DRUG: 10% maltose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Where-there-is-no-psychiatrist Integrated Personal Therapy" Among Community-Dwelling Older Adults
Status: COMPLETED
Conditions: Older Adults|Mental Health|Mindfulness|Solution-focused Brief Therapy
Interventions: BEHAVIORAL: Where-there-is-no-psychiatrist Integrated Personal Therapy (WIPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Green Fluorescent Dye and Radioactive Dye for Sentinel Lymph Node Biopsy in Pediatric Cancers
Status: COMPLETED
Conditions: Pediatric Patients With Solid Tumors
Interventions: PROCEDURE: Sentinel Lymph Node Biopsy|DRUG: indocyanine green (ICG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Randomised, Double-blind, Placebo-controlled, 12 Week Trial to Evaluate the Effect of Tiotropium Inhalation Capsules (Spiriva) on the Magnitude of Exercise, Measured Using an Accelerometer, in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium Bromide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT