pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Distal Femur Fx: ORIF(Open Reduction and Internal Fixation) vs DFR (Distal Femur Replacement Total Knee Arthroplasty)
Status: RECRUITING
Conditions: Distal Femur Fracture
Interventions: OTHER: Timed Up and Go Test on subjects with ORIF of distal femur fractures|OTHER: Koos Jr assesment on subjects with ORIF of distal femur fractures|OTHER: Timed Up and Go Test on subjects with DFR of distal femur fracture|OTHER: Koos Jr assesment on subjects with DFR of distal femur fracture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3832479 (LY-CoV016) in Healthy Participants 1
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3832479|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Research Study Looking Into Blood Levels of Three Different Formulations of the Study Medicine Ziltivekimab
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Ziltivekimab B|DRUG: Ziltivekimab D|DRUG: Ziltivekimab C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands
Status: COMPLETED
Conditions: Flavivirus Infection|Alphavirus Infections|Malaria|Parasitic Disease|Leptospirosis|Hypertension|Metabolic Syndromes
Interventions: OTHER: diagnosis, treatment and education
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Reduced Carbohydrate Diet Intervention for Polycystic Ovary Syndrome (PCOS)
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DIETARY_SUPPLEMENT: Reduced Glycemic Load Diet|DIETARY_SUPPLEMENT: Standard Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sunvozertinib Combined With Chemotherapy for EGFRm After EGFR-TKI Treatment Failure：Phase I/II
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Sunvozertinib|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: β-RELIEVED - REsponse in Acute fLare and In prEVEntion of episoDes of Re-flare in Gout - Extension 3 (E3)
Status: COMPLETED
Conditions: Acute Gouty Arthritis Flares
Interventions: DRUG: ACZ885|DRUG: Triamcinolone acetonide 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficiency of PENG Block and ESP Block Used for Postoperative Analgesia in Elective Hip Surgery
Status: COMPLETED
Conditions: Pain, Postoperative|Anesthesia, Regional|Hip Surgery|Ultrasound-Guided
Interventions: PROCEDURE: Lumbar Erector Spinae Plane Block|PROCEDURE: Pericapsular Nerve Group Block|PROCEDURE: no peripheral block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Trial of Combined Radiotherapy and Vertebroplasty for Patients With Painful Metastatic Spinal Lesions
Status: RECRUITING
Conditions: Spinal Metastases
Interventions: RADIATION: Radiotherapy|PROCEDURE: Vertebropladty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VS002A in the Treatment of Acute Watery Diarrhea in Infants and Young Children
Status: COMPLETED
Conditions: Acute Watery Diarrhoea
Interventions: DIETARY_SUPPLEMENT: VS002A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Topical Application of Hypertonic Saline on Melanoma on Its Sizes and Number.
Status: NOT_YET_RECRUITING
Conditions: Melanoma (Skin)
Interventions: DRUG: Sodium Chloride Granules|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noise-augmented Automatic Speech Recognition for Speech Treatment in Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: Immediate treatment|BEHAVIORAL: Deferred treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FOCUS ADHD Mobile Health App for Adult ADHD Patients
Status: COMPLETED
Conditions: ADHD
Interventions: DRUG: Psychostimulant|DEVICE: FOCUS ADHD App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: APR-246 in Combination With Acalabrutinib or Venetoclax Based Therapy in Subjects With R/R Non Hodgkin Lymphomas (NHL)
Status: TERMINATED
Conditions: Non Hodgkin Lymphoma|Chronic Lymphocytic Leukemia|Mantle Cell Lymphoma
Interventions: DRUG: APR-246 (eprenetapopt) + Acalabrutinib in CLL|DRUG: APR-246 (eprenetapopt) + Venetoclax + Rituximab in CLL|DRUG: APR-246 (eprenetapopt) + (Acalabrutinib, OR, (Venetoclax +Rituximab)), in CLL and/or MCL and/or RT|DRUG: APR-246 (eprenetapopt) + Venetoclax + Rituximab in RT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Fludrocortisone Dose Response Relationship in Septic Shock - FluDReSS
Status: COMPLETED
Conditions: Critically Ill|Septic Shock
Interventions: DRUG: Fludrocortisone Acetate|DRUG: Fludrocortisone Acetate|DRUG: Fludrocortisone Acetate|OTHER: Standard Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxidative Stress Links Aging, Activity, and Mobility Limitation
Status: TERMINATED
Conditions: Aging
Interventions: DIETARY_SUPPLEMENT: Vitamins C, E, and alpha lipoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: External Physical Vibration Lithecbole(EPVL) Versus Traditional Treatment for 4-10 mm Ureteral Stone
Status: UNKNOWN
Conditions: Ureteral Calculi
Interventions: DEVICE: External Physical Vibration Lithecbole (EPVL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deferoxamine for the Prevention of Cardiac Surgery-Associated Acute Kidney Injury
Status: RECRUITING
Conditions: Acute Kidney Injury
Interventions: DRUG: Deferoxamine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Non-typable Haemophilus Influenzae and Pneumococcal Protein Vaccine Formulations in Young Adults
Status: COMPLETED
Conditions: Streptococcus Pneumoniae|Haemophilus Influenzae
Interventions: BIOLOGICAL: GSK2231395A|BIOLOGICAL: Engerix-B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Determine if Levetiracetam Will Assist Those Suffering From Chronic Idiopathic Axonal Polyneuropathy.
Status: COMPLETED
Conditions: Chronic Idiopathic Axonal Polyneuropathy
Interventions: DRUG: levetiracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CQSP in Malawi: Chloroquine and Sulfadoxine-pyrimethamine Efficacy for the Treatment of Malaria in Malawi
Status: COMPLETED
Conditions: Malaria|Plasmodium Falciparum Malaria
Interventions: DRUG: chloroquine sulfate|DRUG: sulfadoxine/pyrimethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accuracy of Conventional and Digital Impression Techniques Used for Maxillary Hybrid Prosthesis
Status: COMPLETED
Conditions: Prosthesis Durability
Interventions: OTHER: impression techniques for implant used for maxillary screw retained hybrid prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Repetitive Transcranial Magnetic Stimulation on Fear of Cancer Recurrence: mPFC-amygdala-hippocampus
Status: NOT_YET_RECRUITING
Conditions: Psychology
Interventions: DEVICE: low-frequency repetitive transcranial magnetic stimulation|DEVICE: sham low-frequency repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EMPower: Electronic Media Powering Positive Health Changes in Youth
Status: COMPLETED
Conditions: Hypertension|Prehypertension|Overweight|Obesity|Hypertrophy, Left Ventricular
Interventions: BEHAVIORAL: Electronic Media Application|BEHAVIORAL: Standard of care education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Placebo-controlled Safety and Dose-finding Study for the Use of the IL-6 Inhibitor Clazakizumab in Patients With Life-threatening COVID-19 Infection
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Clazakizumab 25 mg|DRUG: Clazakizumab 12.5 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash)
Status: COMPLETED
Conditions: Dental Plaque|Gingivitis
Interventions: DRUG: Triclosan/fluoride toothpaste|DRUG: stannous fluoride toothpaste|DRUG: fluoride only toothpaste|DRUG: Cetylpyridinium chloride mouthwash|DRUG: Fluoride only mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Triple Antibiotic Paste as an Intracanal Medication With an Anti-Inflammatory Drug on Post-operative Pain.
Status: COMPLETED
Conditions: Asymptomatic Necrotic Teeth
Interventions: OTHER: triple antibiotic paste with an anti-inflammatory drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Bevacizumab (Avastin) in Participants With Newly Diagnosed Locally Advanced Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DRUG: Bevacizumab|DRUG: Oxaliplatin|DRUG: Folinic Acid|DRUG: 5-fluorouracil|RADIATION: Preoperative Radiotherapy|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Screening for Individual Susceptibility Factors to Immersion Pulmonary Edema
Status: RECRUITING
Conditions: Pulmonary Edema
Interventions: OTHER: Terrestrial exercise|OTHER: Swimming exercise|DEVICE: Transthoracic cardiac ultrasound|DEVICE: Transthoracic pulmonary ultrasound|BIOLOGICAL: Blood collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Use of FDG PET as Predictor of Residual Disease and Subsequent Relapse in Patients With NHL and HD Undergoing HDC and ASCT
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin|Hodgkin Disease
Interventions: PROCEDURE: FDG PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Response Induced by a Vaccine Against Group B Streptococcus and Safety in Pregnant Women and Their Offsprings
Status: COMPLETED
Conditions: Streptococcal Infection|Gram-positive Bacterial Infection|Bacterial Infection
Interventions: BIOLOGICAL: Group B Streptococcus Trivalent Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Process Evaluation of a Residence-Based SARS-CoV-2 Testing Participation Pilot
Status: COMPLETED
Conditions: Covid19
Interventions: BEHAVIORAL: Residence-based testing participation pilot (SARS-CoV-2 testing with relaxed social distancing restrictions)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, and Immunogenicity of mRNA-1325 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Zika Virus
Interventions: BIOLOGICAL: mRNA-1325|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: ISIS 3521 in Treating Patients With Advanced, Unresectable, or Metastatic Non-small Cell Lung Cancer or Unresectable or Metastatic Melanoma
Status: COMPLETED
Conditions: Lung Cancer|Melanoma (Skin)
Interventions: BIOLOGICAL: ISIS 3521
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Effectiveness of Transcollation Technology to Reduce Bleeding in Lung Surgery
Status: UNKNOWN
Conditions: Blood Loss, Surgical
Interventions: DEVICE: Transcollation technology|DEVICE: Traditional electrocautery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Different Acupoints Compatibility Difference of the Effect of Treatment of the Diabetic Gastroparesis
Status: UNKNOWN
Conditions: Diabetic Gastroparesis
Interventions: DEVICE: acupuncture|DEVICE: acupuncture|DEVICE: acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Adductor Canal Block vs SPANK Block for TKA
Status: UNKNOWN
Conditions: Osteo Arthritis Knee|Pain, Postoperative|Pain, Acute
Interventions: PROCEDURE: SPANK Block (Sensory Posterior Articular Nerves of the Knee)|PROCEDURE: Adductor Canal Block|DRUG: Ropivacaine Hcl 0.5% Inj Vil 30Ml|DEVICE: Pajunk sonoplex stim needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testosterone Replacement for Male Opioid Agonist Maintained Patients
Status: COMPLETED
Conditions: Chronic Pain|Opioid Addiction|Symptomatic Hypogonadism
Interventions: DRUG: Testosterone replacement|OTHER: Waitlist control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caloric Restriction in Obese Patients With Mild Cognitive Impairment: Effects on Adiposity, Comorbidity and Cognition
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Obesity
Interventions: OTHER: medical care|BEHAVIORAL: caloric restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Early Skin-to-skin Contact on Initiation of Breastfeeding, Newborn Temperature and Duration of Third Stage of Labor
Status: COMPLETED
Conditions: Breastfeeding
Interventions: OTHER: Skin to skin contact
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Strut Coverage With SYNERGY Stents and Bioresorbable Vascular Scaffold in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DEVICE: SYNERGY stent|DEVICE: ABSORB (Everolimus-eluting Bioresorbable Vascular Scaffold)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Urinary Stress Incontinence During or Following Correction of Pelvic Organ Prolapse
Status: WITHDRAWN
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: correction of POP plus preventive continence procedure|PROCEDURE: POP surgery followed by eventual incontinence procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Base-edited Autologous Hematopoietic Stem Cell Transplantation in Treating Patients With β-thalassemia Major
Status: RECRUITING
Conditions: Beta-Thalassemia
Interventions: BIOLOGICAL: CS-101 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ofatumumab vs Physician's Choice in Subjects With Bulky Fludarabine-Refractory Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukaemia
Interventions: DRUG: Ofatumumab|DRUG: Physicians' Choice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Understanding Treatment Response With Naltrexone Among White Alcoholics
Status: COMPLETED
Conditions: Alcoholism
Interventions: DRUG: Placebo Oral Tablet|DRUG: Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Addition of Popliteal Plexus Block to Continuous Femoral Nerve Block for Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: Ropivacaine 0.5% Injectable Solution|DRUG: Ropivacaine 0.5% Injectable Solution|DRUG: Ropivacaine 0.5% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Palbociclib With Cetuximab and IMRT for Locally Advanced Squamous Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer|Locally Advanced
Interventions: DRUG: Palbociclib|DRUG: Palbociclib|DRUG: Palbociclib|DRUG: Palbociclib|DRUG: Cetuximab|RADIATION: Intensity Modulated Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Utility of Ultrasound Assessment of the Inferior Vena Cava in Patients With Sepsis and Dehydration
Status: TERMINATED
Conditions: Sepsis|Gastroenteritis|Dehydration
Interventions: DEVICE: SonoSite Maxx Series Ultrasound System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Amoxicillin Bioequivalence Study Brazil - Fast
Status: COMPLETED
Conditions: Infections, Bacterial
Interventions: DRUG: Amoxicillin powder for oral suspension (Clamoxyl®) 500mg/5mL|DRUG: Amoxil® 500mg/5mL powder for oral suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bioequivalence Study of Dr.Reddys Laboratories Limited, Glimepiride 1 mg Tablets in Healthy Subjects Under Fed Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Glimepiride tablets 1 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of SARS-CoV-2 mRNA Vaccine (SYS6006) in Chinese Healthy Adults Aged 18 -59 Years.
Status: ACTIVE_NOT_RECRUITING
Conditions: SARS-CoV-2
Interventions: BIOLOGICAL: 20 μg dose of SYS6006|BIOLOGICAL: 30 μg dose of SYS6006|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cognitive Functioning in Opioid Use Disorder
Status: SUSPENDED
Conditions: Opioid Use|Cognitive Change|Opioid-use Disorder
Interventions: OTHER: CogMed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Bexagliflozin Compared to Placebo as Add-on Therapy to Metformin in Type 2 Diabetes Subjects
Status: COMPLETED
Conditions: Type2 Diabetes Mellitus
Interventions: DRUG: Bexagliflozin tablets, 20 mg|DRUG: Bexagliflozin tablets, placebo|DRUG: Bexagliflozin tablets, 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Test of Mood and Circadian Rhythm Mechanisms Driving Binge Eating
Status: COMPLETED
Conditions: Eating Disorder|Binge Eating|Circadian Dysregulation
Interventions: DEVICE: Bright Light Exposure|DEVICE: Natural Light Exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Randomized Controlled Study of Immune Checkpoint Maintenance Therapy After Radiotherapy and Chemotherapy for Locally Advanced Head and Neck Tumors Based on Peripheral Blood CD8Tex Detection in Peripheral Blood
Status: RECRUITING
Conditions: Locally Advanced Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Sintilimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Immersive Virtual Reality Based Training for Rehabilitation of Subacute Stroke
Status: TERMINATED
Conditions: Immersion Virtual Reality Training ,Stroke, Upper Extremity, Randomized Controlled Trial
Interventions: OTHER: immersion virtual reality (VR)-based rehabilitation|OTHER: traditional rehabilitation training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of EM-1421 for the Treatment of Cervical Intraepithelial Neoplasia
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia
Interventions: DRUG: EM-1421
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Inhaled Glucocorticosteroid Administration in Asthma Patients
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Budesonide,hydrofluoroalkane-beclomethasone dipropionate|DRUG: Budesonide,hydrofluoroalkane-beclomethasone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Forest Therapy on Cognitive Performance and Mental Health in Older Adults Health in Older Adults
Status: UNKNOWN
Conditions: Forest Therapy for Cognition
Interventions: BEHAVIORAL: Forest therapy training|BEHAVIORAL: Senior fitness training|BEHAVIORAL: Board Games
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Quadratus Lumborum Block vs Transversus Abdominis Plane Block for Post-prostatectomy Analgesia
Status: TERMINATED
Conditions: Prostatic Cancer|Pain, Postoperative|Pain|Anesthetics, Local
Interventions: DIAGNOSTIC_TEST: Quadratus Lumborum block|DIAGNOSTIC_TEST: Tranversus Abdominis plane block|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safely Reduce Cystoscopic Evaluations for Hematuria Patients
Status: RECRUITING
Conditions: Hematuria|Urothelial Neoplasm|Urothelial Carcinoma|Bladder Cancer
Interventions: DIAGNOSTIC_TEST: urine-first strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Tolerance and Safety of a Ketone-Promoting Food Ingredient
Status: COMPLETED
Conditions: Tolerance
Interventions: OTHER: Ketone- Promoting Food Ingredient #1|OTHER: Ketone- Promoting Food Ingredient #2|OTHER: Ketone Free Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Minimizing Ventricular Pacing
Status: UNKNOWN
Conditions: Sinus Node Disease.|First Degree Atrioventricular Block.
Interventions: DEVICE: Prolonging atrioventricular (AV) delay.|DEVICE: Standard atrioventricular (AV) delay.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Human Endostatin Continued Pumping Into Vein Combining With CCRT in Unresectable Stage III NSCLC
Status: COMPLETED
Conditions: Stage III Non-small-Cell Lung Cancer
Interventions: DRUG: Recombinant human endostatin|DRUG: Etoposide (50mg/m2) IV (in the vein) on day 1 to day 5 of a 28-day cycle for 2 cycles|DRUG: cisplatinum (50mg/m2) IV (in the vein) on day 1 and day 8 of a 28-day cycle for 2 cycles|OTHER: laboratory biomarker analysis|OTHER: CT perfusion imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of a Physiotherapy Technique in Patients With Chronic Myofascial Temporomandibular Disorder
Status: COMPLETED
Conditions: Myofascial Pain Syndrome|Temporomandibular Disorder
Interventions: OTHER: Manual pressure release technique on trigger points.|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BE Study of Fluticasone Propionate/Salmeterol Inhalation Powder in Asthma Patients
Status: COMPLETED
Conditions: Bronchial Asthma
Interventions: DRUG: Fluticasone propionate/salmeterol 100/50 µg|OTHER: Placebo|DRUG: Advair Diskus 100/50 Dry Powder Inhaler, 60 ACTUAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: New Tool to Enhance Post-stroke Upper Extremity Disability
Status: UNKNOWN
Conditions: Stroke
Interventions: OTHER: START - Startle Adjuvant Rehabilitation Therapy|OTHER: Sham Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Therapist Guided Internet-delivered Treatment for Adults With ADHD (Attention Deficit / Hyperactivity Disorder) - an Open Effectiveness Trial in Routine Care
Status: RECRUITING
Conditions: ADHD|ADHD - Combined Type|ADHD Predominantly Inattentive Type|ADHD, Predominantly Hyperactive - Impulsive
Interventions: BEHAVIORAL: MinADHD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of the Optimal Treatment Period and Long-term Efficacy of Functional Electrical Stimulation (FES) on Sleep Bruxism
Status: COMPLETED
Conditions: Temporomandibular Disorder|Headache
Interventions: DEVICE: Grindcare® (Biofeedback)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Corrected QT Interval and Drug-Drug Interaction of Trastuzumab on Carboplatin in the Presence of Docetaxel in Patients With HER2-Positive Metastatic or Locally Advanced Inoperable Cancer
Status: COMPLETED
Conditions: Solid Cancers
Interventions: DRUG: carboplatin|DRUG: docetaxel|DRUG: trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Adenocarcinoma|ERBB2 Gene Amplification|Recurrent Uterine Corpus Carcinoma|Stage III Uterine Corpus Cancer AJCC v7|Stage IV Uterine Corpus Cancer AJCC v7
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FIH Study to Evaluate the Tolerability of PF-07832837 in Healthy Adults and Patients
Status: NOT_YET_RECRUITING
Conditions: Healthy Participants|Atopic Dermatitis
Interventions: DRUG: PF-07832837|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cervical Kinematics' Reliability: Zero Positioning Using a 3-D-bulls Eye Spirit Level
Status: COMPLETED
Conditions: Kinematics|Reliability|Cervical
Interventions: OTHER: Zebris CMS 70|OTHER: 3-D Bulls Eye Spirit Meter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Randomized Clinical Study Comparing a Fully-Coated Cementless Stem Versus a Cemented Stem for Total Hip Replacements
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: Fully coated Prodigy stem|DEVICE: Cemented Endurance Stem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Combined Effect of Dairy and Exercise on Bone and Inflammation
Status: TERMINATED
Conditions: Healthy|Females|Bone|Inflammation
Interventions: BEHAVIORAL: Resistance and Plyometric Exercise|DIETARY_SUPPLEMENT: Carbohydrate (Maltodextrin powder mixed with water)|DIETARY_SUPPLEMENT: Skim Milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study To Evaluate The Efficacy And Safety Of Ciprofloxacin Extended-Release (Cipro® XR) 1000 mg Tablets Given Once Daily For 7 To 14 Days In The Treatment Of Patients 18 Years Or Older With Complicated Urinary Tract Infections Caused By Pseudomonas Aeruginosa And Other Common Uropathogens
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: DRUG: Cipro XR (Ciprofloxacin, BAYQ3939)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Infant Flow Biphasic Nasal Continuous Airway Pressure (NCPAP) Versus Infant Flow NCPAP for the Facilitation of Extubation in Infants </= 1250 Grams
Status: TERMINATED
Conditions: Infant, Premature, Diseases|Bronchopulmonary Dysplasia|Apnea of Prematurity
Interventions: PROCEDURE: Biphasic Infant flow NCPAP|PROCEDURE: CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Infliximab Biosimilar for Intravenous Drip Infusion 100 mg "Pfizer" Drug Use Investigation (Psoriasis)
Status: COMPLETED
Conditions: Psoriasis Vulgaris|Psoriasis Arthropathica|Pustular Psoriasis|Erythrodermic Psoriasis
Interventions: DRUG: Infliximab [infliximab biosimilar 3]
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence Study of Two Formulations of Rivaroxaban Tablets 10 mg in Healthy Male Volunteers in Fasting Conditions
Status: UNKNOWN
Conditions: Bioequivalence
Interventions: DRUG: Rivaroxaban film-coated tablet 10 mg|DRUG: Xarelto® film-coated tablet 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Phase 1B/2A Trial of Combination of ASTX727 With ASTX029 in Acute Myeloid Leukemia
Status: SUSPENDED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: ASTX727|DRUG: ASTX029-01
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate if Multiple Doses of Ketoconazole Change the Blood Concentration of YM150 (Darexaban)
Status: COMPLETED
Conditions: Pharmacokinetics of Darexaban and Metabolites|Healthy Subjects
Interventions: DRUG: darexaban|DRUG: ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Neoadjuvant Treatment of Upper Urinary and Muscular Invasive Bladder Urothelial Carcinoma
Status: UNKNOWN
Conditions: Upper Tract Urinary Carcinoma|Muscle-invasive Bladder Cancer
Interventions: DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Exploration Study With Birabresib (MK-8628) in Participants With Selected Hematologic Malignancies (MK-8628-005)
Status: TERMINATED
Conditions: AML Including AML de Novo and AML Secondary to MDS|DLBCL
Interventions: DRUG: Birabresib Dose 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Danicamtiv on the Drug Levels of Midazolam in Participants With Stable Heart Failure
Status: COMPLETED
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: Danicamtiv|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Pharmacodynamics of Lemborexant in Korean Participants With Insomnia Disorder
Status: RECRUITING
Conditions: Sleep Initiation and Maintenance Disorders
Interventions: DRUG: Lemborexant|OTHER: PBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy Of Lidocaine Infusion IN Chronic Unilateral Migraine Headache
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Migraine, Headache
Interventions: DRUG: Lidocaine IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Early Skin to Skin Contact on Breast Feeding Behaviour in Term Newborns: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Breastfeeding
Interventions: OTHER: skin to skin contact|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Erlotinib Hydrochloride With or Without Bevacizumab in Treating Patients With Stage IV Non-small Cell Lung Cancer With Epidermal Growth Factor Receptor Mutations
Status: COMPLETED
Conditions: EGFR Exon 19 Deletion Mutation|EGFR NP_005219.2:p.L858R|Lung Non-Squamous Non-Small Cell Carcinoma|Stage IV Lung Non-Small Cell Cancer AJCC v7
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Erlotinib|DRUG: Erlotinib Hydrochloride|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of an Amino-acid Supplement on Hepatic Lipid Metabolism
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Fructose+maltodextrin placebo|DIETARY_SUPPLEMENT: amino-acid + fructose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Health Outcomes of Patients With Stable Chronic Disease Managed With a Healthcare Kiosk
Status: UNKNOWN
Conditions: Hypertension|Hyperlipidemia; Mixed|Diabetes Mellitus
Interventions: DEVICE: Kiosk intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Safety Study of SGN-2FF for Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung|Carcinoma, Renal Cell|Breast Neoplasms|Urinary Bladder Neoplasm|Carcinoma, Squamous Cell of Head and Neck|Colorectal Neoplasms|Gastric Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: SGN-2FF|DRUG: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Nateglinide Treatment in Renal Transplant Recipients
Status: COMPLETED
Conditions: Renal Transplant Recipients|Posttransplant Diabetes Mellitus|Posttransplant Impaired Glucose Tolerance
Interventions: DRUG: Nateglinide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nab-Paclitaxel and Atezolizumab Before Surgery in Treating Patients With Triple Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Adenocarcinoma|Invasive Breast Carcinoma|Triple-Negative Breast Carcinoma
Interventions: DRUG: Atezolizumab|DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Natural Killer Cell Engager (SAR443579) With Different Agents in Participants With Hematological Malignancies
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: SAR443579|DRUG: venetoclax|DRUG: azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel and Carboplatin in Treating Patients With Persistent or Recurrent Stage III or Stage IV Uterine Cancer
Status: COMPLETED
Conditions: Sarcoma
Interventions: DRUG: carboplatin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patellar Tendinopathy - Effect of Training and Enhancement of the Collagen Synthesis by Insulin-like Growth Factor-I
Status: UNKNOWN
Conditions: Tendinopathy
Interventions: DRUG: Insulin-like growth factor I|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Study to Evaluate Cannabidiol Liver Enzyme Elevations and Drug Interactions
Status: RECRUITING
Conditions: Cannabidiol|Drug Induced Liver Injury|Drug Interaction
Interventions: DRUG: Cannabidiol|DRUG: Placebo|DRUG: Citalopram|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison Between IORT and Postoperative Radiotherapy in Breast Conserving Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Quality of Life
Interventions: RADIATION: intraoperative radiotherapy|RADIATION: postoperative radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnosis and Phenotype Characterisation Using Genomics in Patients With Inherited Bone Marrow Failure (IBMDx Study)
Status: RECRUITING
Conditions: Inherited BMF Syndrome|Inherited Platelet Disorder|Hematologic Diseases
Interventions: DIAGNOSTIC_TEST: whole genome and transcriptome sequencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Ideal LiST Session Frequency Protocol for CPPS Treatment
Status: COMPLETED
Conditions: Chronic Pelvic Pain Syndrome|Chronic Non-bacterial Prostatitis Type IIIB
Interventions: DEVICE: Low intensity shockwave therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ocrelizumab in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Are Naive to Methotrexate (FILM)
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Methotrexate|DRUG: Ocrelizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tobemstomig Plus Platinum-Based Chemotherapy vs Pembrolizumab Plus Platinum-Based Chemotherapy in Participants With Previously Untreated Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Tobemstomig|DRUG: Pembrolizumab|DRUG: Paclitaxel|DRUG: Pemetrexed|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Low Level Laser Therapy and Word Recognition in Hearing Impaired Individuals
Status: COMPLETED
Conditions: Sensorineural Hearing Loss
Interventions: DEVICE: The Hearing Laser|DEVICE: Placebo Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Varenicline in Heavy Drinking Smokers
Status: WITHDRAWN
Conditions: Cigarette Smoking|Alcohol Consumption
Interventions: DRUG: Varenicline|DRUG: Placebo pill (for varenicline)|DRUG: Alcohol|DRUG: placebo beverage (for alcohol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effects of Acid-Reducing Agent(s) on JNJ-64417184 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: JNJ-64417184|DRUG: Lansoprazole|DRUG: Famotidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effects of Bilateral Cerebellar rTMS on Cortical Function
Status: COMPLETED
Conditions: Dysphagia|Swallowing Disorder
Interventions: DEVICE: Cerebellar targeted rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Early Robotic Ablation by Substrate Elimination of Ventricular Tachycardia
Status: COMPLETED
Conditions: Ventricular Tachycardia
Interventions: PROCEDURE: Robotic VT Ablation|OTHER: Conventional Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy on NT-proBNP of Recombinant Human Neuregulin-1 in Chronic Heart Failure Patients
Status: TERMINATED
Conditions: Chronic Heart Failure
Interventions: DRUG: rhNRG-1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Passive Tactile Stimulation for Stroke Rehabilitation
Status: COMPLETED
Conditions: Stroke|Stroke, Ischemic|Stroke Hemorrhagic|Spasticity as Sequela of Stroke
Interventions: DEVICE: Vibration pattern|DEVICE: No vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 20-Week Repeat Oral Dose Study of AKB-6548 in Participants With Chronic Kidney Disease and Anemia
Status: COMPLETED
Conditions: Anemia|Chronic Kidney Disease
Interventions: DRUG: AKB-6548|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Microbial Growth in the Suture Thread, After Application of Different Antiseptic Gels in Mandibular Third Molars Extraction
Status: COMPLETED
Conditions: Wisdom Teeth|Oral Surgery|Third Molar Surgery|Bioadhesive Gel|Suture Bacteria|Antiseptic Gel|Chistosan|Clorhexidine Gel Bacteria|Clorhexidine-chitosan|Bacterial Growth
Interventions: DRUG: Placebo gel|DRUG: Clorhexidine gel|DRUG: Clorhexidine-Chitosan gel|DRUG: Hyaluronic Acid gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Efficacy of GSK Biologicals' Adjuvants in Combination With the Antigen of the Hepatitis B Vaccine
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Engerix-B™|BIOLOGICAL: Fendrix™|BIOLOGICAL: GSK Biologicals' Hepatitis B vaccines (GSK223192A)|BIOLOGICAL: HBsAg (Booster injection)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Post-marketing Surveillance of the Safety, Tolerability and Efficacy of Vytorin (Ezetimibe + Simvastatin) Tablet Among Filipino Patients (Study P05647)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Vytorin (R) (Ezetimibe + Simvastatin)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Acetylcholinesterase Inhibitors on Bone Metabolism
Status: NOT_YET_RECRUITING
Conditions: Osteoporosis
Interventions: DRUG: Donepezil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outcomes Post Treatment: Impact on Motor Impairment of Sleep Efficiency in SCI (OPTIMISE SCI Trial)
Status: RECRUITING
Conditions: Spinal Cord Injuries|Spine Disease
Interventions: DEVICE: Continuous positive airway pressure (CPAP) therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT