pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Neoadjuvant Chemotherapy Versus Surgery Alone in Patients With High-Grade UTUC
Status: COMPLETED
Conditions: High-Grade Upper Tract Urothelial Carcinoma
Interventions: PROCEDURE: Radical nephroureterectomy|PROCEDURE: Distal ureterectomy|DRUG: Neoadjuvant Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Green LEP vs ThuLEP in Management of Marked Enlarged Prostate
Status: RECRUITING
Conditions: Prostatic Hyperplasia With Urinary Obstruction
Interventions: PROCEDURE: ThuLEP|PROCEDURE: Green LEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study on the Efficacy and Safety of Nebivolol Monotherapy in Hispanic Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Nebivolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: COPD: A Multi-center Supervised Tele-rehabilitation Study
Status: NOT_YET_RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: home-based telerehabilitation group|BEHAVIORAL: center-based traditional rehabilitation group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: u-STOP LVAD Bleed: Utilization of Umbilical Cord Lining Stem Cells (ULSCs) To Prevent Left Ventricular Assist Device (LVAD) Associated Angiodysplastic Bleeding
Status: COMPLETED
Conditions: Angiodysplastic Bleeding
Interventions: DRUG: Intravenous Infusion of UCLSCs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: What is the Burden of Housing in Rural Areas for Individuals With Hemiplegia?
Status: COMPLETED
Conditions: Hemiplegia
Interventions: OTHER: The Stroke-Specific Quality of Life (SS-QoL) scale|OTHER: The Stroke Self-Efficacy Questionnaire (SSEQ)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety & Efficacy Study of ORGN001 (Formerly ALXN1101) in Pediatric Patients With MoCD Type A Currently Treated With rcPMP
Status: COMPLETED
Conditions: Molybdenum Cofactor Deficiency, Type A
Interventions: DRUG: ORGN001 (formerly ALXN1101)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of Doxercalciferol in Patients With Chronic Kidney Disease, Stage 3 or 4, and Secondary Hyperparathyroidism
Status: COMPLETED
Conditions: Secondary Hyperparathyroidism|Renal Failure|Chronic Renal Insufficiency
Interventions: DRUG: Hectorol (doxercalciferol capsules), 0.5mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: BMS-247550 Plus Carboplatin in Treating Patients With Recurrent or Refractory Solid Tumors
Status: TERMINATED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: ixabepilone|DRUG: carboplatin|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SOX Regimen as Neoadjuvant Chemotherapy for AJCC Stage II-III Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Adenocarcinoma
Interventions: DRUG: Oxaliplatin+S-1|DRUG: Adjuvant Oxaliplatin/S-1（SOX）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Darunavir in Combination With Cobicistat or Ritonavir, and Dabigatran Etexilate in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Dabigatran Etexilate|DRUG: DRV/COBI|DRUG: Ritonavir|DRUG: Darunavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pilot Study Person-centred Tablet Intervention
Status: COMPLETED
Conditions: Dementia|Mobile Applications|Computers|Neurological Rehabilitation|Activities of Daily Living
Interventions: BEHAVIORAL: FMA group|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: POTS NET mRNA Functional Correlation With NET Activity
Status: ENROLLING_BY_INVITATION
Conditions: Postural Tachycardia Syndrome
Interventions: DIAGNOSTIC_TEST: NET mRNA level|DIAGNOSTIC_TEST: Plasma catechols|DIAGNOSTIC_TEST: Urine Catechols
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase IV, Open-label Single-arm Study Investigating the Pharmacokinetics and Pharmacodynamics of the Antiretroviral Combination of Rilpivirine and Ritonavirboosted Darunavir in Therapy-naive HIV-1 Infected Patients.
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Darunavir, Ritonavir and Rilpivirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Colorectal Liver Metastases With Immunotherapy and Bevacizumab
Status: COMPLETED
Conditions: Colorectal Neoplasms|Neoplasm Metastasis|Colonic Neoplasms|Rectal Neoplasms
Interventions: DRUG: Atezolizumab|DRUG: Bevacizumab|DRUG: Oxaliplatin|DRUG: Levoleucovorin|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Voxel Based Diffusion Tensor Imaging in Predicting Response in Patients With Brain Metastases Undergoing Whole Brain Radiation Therapy or Stereotactic Radiosurgery
Status: WITHDRAWN
Conditions: Tumors Metastatic to Brain|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: PROCEDURE: diffusion tensor imaging|RADIATION: whole-brain radiation therapy|RADIATION: stereotactic radiosurgery|PROCEDURE: contrast-enhanced magnetic resonance imaging|PROCEDURE: diffusion-weighted magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Investigate the Absorption, Metabolism and Excretion of Talampanel
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: Talampanel (non-radiolabeled), [14C] Talampanel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Safety and Effectiveness of a Canaloplasty Device in Subjects With Open-Angle Glaucoma
Status: NOT_YET_RECRUITING
Conditions: POAG
Interventions: DEVICE: Canaloplasty Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 13C Pyruvate DNP MR Spectroscopy for Lymphoma Treatment Response Assessment
Status: NOT_YET_RECRUITING
Conditions: Patient Outcome Assessment
Interventions: DRUG: hyperpolarized 13C-labeled pyruvate from dynamic nuclear polarization (DNP) magnetic resonance spectroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peri-implantitis - Reconstructive Surgical Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Peri-Implantitis
Interventions: PROCEDURE: Open flap debridement|DEVICE: Bone replacement graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Elotuzumab, Pomalidomide, & Dexamethasone (Elo-Pom-Dex) With Second Autologous Stem Cell Transplantation for Relapsed Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma in Relapse
Interventions: DRUG: Elotuzumab|DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sintilimab Plus Bevacizumab in Recurrent/Persistent Ovarian Clear Cell Carcinoma
Status: COMPLETED
Conditions: Ovarian Clear Cell Carcinoma
Interventions: DRUG: Sintilimab|DRUG: Bevacizumab Biosimilar IBI305
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Retrospective, Observational, Multicenter Study to Evaluate the Safety and Performance of POLYSITE® and SEESITE® Implantable Ports
Status: UNKNOWN
Conditions: Veinous|Chemotherapy|Antibiotics|Antiviral Drugs|Parenteral Nutrition|Blood Transfusion|Blood Derivatives Transfusion|PMCF Study
Interventions: DEVICE: Implantation of veinous access ports
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Obstructive Sleep Apnea Syndrome on Metabolic Syndrome in Severe Obesity
Status: UNKNOWN
Conditions: Metabolic Syndrome|Insulin Resistance|Adipokines|Cytokines
Interventions: DEVICE: CPAP|BEHAVIORAL: Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-center Prospective Study Determining the Sustainability of Pain Relief and Psychosocial and Functional Responses When Utilizing a Multiple Waveform Enabled Neurostimulator
Status: COMPLETED
Conditions: Chronic Pain|Intractable Pain
Interventions: DEVICE: Prodigy, Prodigy MRI or Proclaim Elite IPG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerance of Intraperitoneal (IP) Nivolumab After Extensive Debulking Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients With Advanced Ovarian Carcinoma
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: DRUG: Intraperitoneal (IP) nivolumab infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: mRNA Booster Vaccine(SW-BIC-213) Compared With Pfizer andSinopharm Against Emerging VOCs
Status: ACTIVE_NOT_RECRUITING
Conditions: Immunogenicity|Safety|Efficacy
Interventions: BIOLOGICAL: SW-BIC-213;SARS-Cov-2.|BIOLOGICAL: Sinopharm (BIBP);SARS-Cov-2.|BIOLOGICAL: Pfizer(BNT162b2);SARS-Cov-2.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Curcumin in Oral Submucous Fibrosis
Status: UNKNOWN
Conditions: Oral Submucous Fibrosis
Interventions: DRUG: 10% Curcumin mucoadhesive gel|DRUG: Curcumin capsules 500mg|DRUG: 5% curcumin mucoadhesive gel + Curcumin capsules 250 mg|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Phase 2 Study Assessing the Efficacy of Triheptanoin, an Anaplerotic Therapy in Huntington's Disease
Status: COMPLETED
Conditions: Huntington Disease
Interventions: DRUG: Triheptanoin oil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Cork Splint Materials Instead of Plaster Splint for Children
Status: COMPLETED
Conditions: Wrist Fractures|Forearm Fractures|Elbow Fractures|Ankle Fractures|Foot Fractures|Wounds and Injuries
Interventions: DEVICE: Cork splint materials (instead of plaster splint)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Collect Data on the Treatment Pattern of Xarelto + Acetylsalicylic Acid in the Routine Clinical Practice in Patients Who Are Suffering From a Condition That Narrows the Blood Vessels Supplying the Heart and / or a Condition That Most Commonly Narrows the Blood Vessel in the Legs
Status: COMPLETED
Conditions: Coronary Artery Disease|Peripheral Artery Disease
Interventions: DRUG: Rivaroxaban (BAY59-7939, Xarelto)|DRUG: Acetylsalicylic acid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multiple Class I Peptides & Montanide ISA 51 VG w Escalating Doses of Anti-PD-1 ab BMS936558
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: MART-1|BIOLOGICAL: NY-ESO-1|BIOLOGICAL: gp100:209-217(210M)|BIOLOGICAL: gp100:280-288(288V)|DRUG: Montanide ISA 51 VG|BIOLOGICAL: BMS-936558
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I of SS109 in Hemophilia A or and B With Inhibitors
Status: COMPLETED
Conditions: Hemophilia A With Inhibitor|Hemophilia B With Inhibitor|Factor VII Deficiency
Interventions: BIOLOGICAL: SS109
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study To Evaluate Safety And Efficacy Of Investigational Drug - PF04937319 In Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Placebo|DRUG: PF-04937319 - 3mg|DRUG: PF-04937319 - 20mg|DRUG: PF-04937319 - 50mg|DRUG: PF-04937319 - 100mg|DRUG: Sitagliptin - 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tislelizumab Combined With Nab-paclitaxel and Gemcitabine for Recurrent Pancreatic Cancer
Status: RECRUITING
Conditions: Recurrent Pancreatic Cancer
Interventions: DRUG: Tislelizumab|DRUG: Nab paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Therapy of Pembrolizumab + Ramucirumab for PD-L1 Positive Stage IB-IIIA Lung Cancer (EAST ENERGY)
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer Stage IB|Non-small Cell Lung Cancer Stage II|Non-small Cell Lung Cancer Stage ⅢA
Interventions: DRUG: Pembrolizumab|DRUG: Ramucirumab|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ONO-4578 With and Without ONO-4538 in Subjects Advanced or Metastatic Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced or Metastatic Solid Tumors
Interventions: DRUG: ONO-4578|DRUG: ONO-4538
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: L-tetrahydropalmatine (l-THP) Treatment for Cocaine Use Disorder
Status: WITHDRAWN
Conditions: Cocaine Use
Interventions: DRUG: l-tetrahydropalmatine (l-THP)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ProSat - Effect of Probiotics on Satiety
Status: COMPLETED
Conditions: Obesity|Appetite Regulation
Interventions: DIETARY_SUPPLEMENT: probiotic|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Interferon-Beta Gene Transfer (Ad.hIFN-β) as Treatment for Refractory Colorectal Carcinoma With Liver Metastases
Status: COMPLETED
Conditions: Colorectal Carcinoma|Metastases
Interventions: DRUG: Ad.hIFN-β (BG00001, IDEC-201)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics Comparison Study of JT1801 and NESP® After Single Dose Administration in Chinese Health Male Volunteers
Status: COMPLETED
Conditions: Renal Anemia
Interventions: DRUG: JT1801 60ug|DRUG: NESP 60ug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ondansetron Versus Domperidone for Treating Vomiting in Acute Gastroenteritis in Children
Status: COMPLETED
Conditions: Vomiting in Infants and/or Children|Acute Gastroenteritis
Interventions: DRUG: Ondansetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Tacrolimus vs Mycophenolate Mofetil in Pediatric Patients With Nephrotic Syndrome
Status: COMPLETED
Conditions: Nephrotic Syndrome in Children
Interventions: DRUG: Tacrolimus|DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GOS to Reduce Symptom Severity in IBS
Status: RECRUITING
Conditions: Irritable Bowel Syndrome|Irritable Bowel Syndrome - Constipation|Irritable Bowel Syndrome - Diarrhoea|Irritable Bowel Syndrome - Mixed
Interventions: DIETARY_SUPPLEMENT: Galacto-oligosaccharides (GOS)|DIETARY_SUPPLEMENT: Maltodextrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Microvascular Function Assessment in Healthy Subjects
Status: COMPLETED
Conditions: Physiology of Microvascular Skin
Interventions: DRUG: acetylsalicilic acids (Aspirin)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Magnetic Resonance Imaging-Based Radiation Therapy and Cisplatin in Patients With Stage I, Stage II, Stage III, or Stage IV Cervical Cancer
Status: TERMINATED
Conditions: Cervical Cancer
Interventions: RADIATION: intracavitary balloon brachytherapy|RADIATION: external beam radiation therapy|RADIATION: intensity-modulated radiation therapy|RADIATION: radiation therapy treatment planning/simulation|RADIATION: 3-dimensional conformal radiation therapy|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incobotulinum Toxin A (Xeomin®) As A Treatment For Focal Task-Specific Dystonia Of The Musician's Hand
Status: COMPLETED
Conditions: Dystonia
Interventions: DRUG: incobotulinumtoxin A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety And Efficacy Of Tanezumab In Patients With Chronic Pancreatitis
Status: TERMINATED
Conditions: Chronic Pancreatitis
Interventions: BIOLOGICAL: Tanezumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Module-Based Psychological (MBP) for Community Youths
Status: NOT_YET_RECRUITING
Conditions: Mental Disorder|Depressive Symptoms|Anxiety Symptoms
Interventions: BEHAVIORAL: Module-Based Psychological (MBP) Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anthocyanin Extract and Phospholipid Curcumin in Colorectal Adenoma
Status: UNKNOWN
Conditions: Colorectal Adenoma|Risk Reduction
Interventions: DIETARY_SUPPLEMENT: Mirtoselect® + Meriva®|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: G-CSF in Stimulating Peripheral Stem Cells for Autologous Stem Cell Transplant in Treating Patients With Chronic Phase Chronic Myeloid Leukemia in Complete Remission
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ExoFlo™ Infusion for Post-Acute COVID-19 and Chronic Post-COVID-19 Syndrome
Status: NOT_YET_RECRUITING
Conditions: Covid19|Postviral Syndrome|Dyspnea
Interventions: BIOLOGICAL: Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Decision Making About Breast Reconstruction After Mastectomy: A Patient-Centered Approach
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: Usual care American Society of Plastic Surgeons booklet "Breast Reconstruction"|OTHER: Decision tool|OTHER: Usual Care Group - Outcome Measures|OTHER: Decision Group - Outcome Measures|OTHER: Demographic and Background Questions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy of Sulphadoxine-pyrimethamine and Artemisinin-containing Combination Therapy for Malaria
Status: COMPLETED
Conditions: Malaria (Uncomplicated)
Interventions: DRUG: Sulfadoxine-pyrimethamine|DRUG: sulfadoxine-pyrimethamine plus artesunate|DRUG: lumefantrine plus artemether|BEHAVIORAL: Sleeping under insecticide-treated bednet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propranolol and Pembrolizumab in Advanced Soft Tissue Sarcoma Patients
Status: RECRUITING
Conditions: Soft Tissue Sarcoma Adult|Angiosarcoma|Undifferentiated Pleomorphic Sarcoma
Interventions: DRUG: Propranolol|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Atypical Versus Conventional Antipsychotics in Treating Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: risperidone|DRUG: olanzapine|DRUG: quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Innovating Shorter, All- Oral, Precised, Individualized Treatment Regimen for Rifampicin Resistant Tuberculosis：Contezolid, Delamanid and Bedaquiline Cohort
Status: RECRUITING
Conditions: Pulmonary Tuberculosis|Rifampicin-resistant Tuberculosis
Interventions: DRUG: Bedaquiline|DRUG: Delamanid|DRUG: Contezolid|DRUG: Levofloxacin|DRUG: Moxifloxacin|DRUG: Clofazimine|DRUG: Linezolid|DRUG: Cycloserine|DRUG: Prothionamide|DRUG: Pyrazinamide|DRUG: Para-Aminosalicylic Acid|DRUG: Ethambutol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Cancer
Status: TERMINATED
Conditions: Leukemia|Lymphoma|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases
Interventions: BIOLOGICAL: alemtuzumab|BIOLOGICAL: graft-versus-tumor induction therapy|BIOLOGICAL: rituximab|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: fludarabine phosphate|DRUG: methotrexate|DRUG: tacrolimus|PROCEDURE: allogeneic bone marrow transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Smart Management Strategy for Health (SMASH) Program for Overcoming Cancer Crisis and Growing Positively
Status: COMPLETED
Conditions: Breast Neoplasms|Lung Neoplasms|Colorectal Neoplasms|Stomach Neoplasms
Interventions: BEHAVIORAL: Online health management program|BEHAVIORAL: Health coaching|BEHAVIORAL: Workshop|BEHAVIORAL: Standard health educational booklet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diabetes Mellitus and Vulvovaginal Candidiasis
Status: COMPLETED
Conditions: Diabetes Mellitus|Vulvovaginal Candidiasis
Interventions: DRUG: Boric|DRUG: Fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Venetoclax and AMG 176 in Patients With Relapsed/Refractory Hematologic Malignancies
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|Non-Hodgkin's Lymphoma|Diffuse Large B-cell Lymphoma
Interventions: DRUG: Venetoclax|DRUG: AMG 176
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation on Biological Characteristics of Acupoints in Premature Ovarian Insufficiency
Status: RECRUITING
Conditions: Premature Ovarian Insufficiency
Interventions: DEVICE: all patients and healthy people will receive at least 3 infrared thermal imaging examinations of acupoints and pain threshold examinations of acupoints.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of a c-Met Inhibitor PLB1001 in Patients With PTPRZ1-MET Fusion Gene Positive Recurrent High-grade Gliomas
Status: COMPLETED
Conditions: Glioma
Interventions: DRUG: PLB1001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Innovative Smartphone Application for Adverse Event Management During Breast Cancer Adjuvant Chemotherapy
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: OTHER: use of a smartphone app for adverse event management|OTHER: conventional adverse event management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Delivra Topical Creatine Combined With Oral Creatine for Improving Muscular Power
Status: COMPLETED
Conditions: Muscle Weakness
Interventions: DIETARY_SUPPLEMENT: 3.5 mL/d topical creatine|DIETARY_SUPPLEMENT: 3.5 mL/d topical placebo|DIETARY_SUPPLEMENT: 21 g/d Oral creatine|DIETARY_SUPPLEMENT: 21 g/d oral placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Evobrutinib in Participants With RMS (evolutionRMS 2)
Status: TERMINATED
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: Evobrutinib|DRUG: Placebo (match to Teriflunomide)|DRUG: Teriflunomide|DRUG: Placebo (match to Evobrutinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate ASN008 Topical Gel (TG)
Status: COMPLETED
Conditions: Dermatitis, Atopic|Pruritus|Dermatitis Eczema
Interventions: DRUG: ASN008 TG|DRUG: Placebo TG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Post Admission Cognitive Therapy (PACT) for the Inpatient Treatment of Military Personnel With Suicidal Behaviors
Status: UNKNOWN
Conditions: Suicide, Attempted|Suicidal Ideation Active
Interventions: BEHAVIORAL: Post Admission Cognitive Therapy (PACT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Effect of Dexmedetomidine Alone With Dexmedetomidine Plus Ketamine Combination in CABG
Status: UNKNOWN
Conditions: Hemodynamic Instability
Interventions: DRUG: Dexmedetomidine alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Modified Constraint-Induced Movement Therapy on the Upper Limb Function of Sub-acute Stroke Patients in Peshawar Pakistan
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: OTHER: Modified Constraint-Induced Movement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Collagen-elastin Dermal Substitute in the Treatment of Loss of Cutaneous Substances With Skin Grafts
Status: UNKNOWN
Conditions: Skin Graft|Collagen -Elastin Matrix
Interventions: PROCEDURE: skin graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Teleneuropsychological Intervention in Asymptomatic HIV Seropositive Patients: N&C NeuroChange
Status: WITHDRAWN
Conditions: Telerehabilitation|Neuropsychology|HIV Dementia
Interventions: BEHAVIORAL: Cognitive stimulation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Vitamin D on Metabolic Profile in Overweight or Obese Women
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Leg Wrapping and Norepinephrine for Prevention of Post Spinal Hypotension in C.S
Status: NOT_YET_RECRUITING
Conditions: Post Spinal Hypotension
Interventions: DRUG: Norepinephrine|PROCEDURE: Leg wrapping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sodium Chloride and Protein-Bound Toxin Removal in Hemodiafiltration
Status: COMPLETED
Conditions: End-stage Renal Disease
Interventions: PROCEDURE: HDF NaCl|PROCEDURE: Hemodialysis|PROCEDURE: Standard Predilution Hemodiafiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Prospective Study of the Success of Single Embryo Transfer Implantation Related to Level of Follicular Fluid Cytokines Expression in Low Responders Infertile Patients Treated With r-hLH add-on Therapy in a Second Controlled Ovarian Stimulation Cycle.
Status: UNKNOWN
Conditions: Female Infertility
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A New 3D Virtual Reality-based Upper Limb Training to Improve Dexterity in Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: OTHER: virtual reality upper limb hand training|OTHER: virtual reality control training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PegIntron Versus Adefovir in the Treatment of Chronic Hepatitis B (CHB) e Antigen Positive Patients in Taiwan (P04498/MK-4031-278)
Status: COMPLETED
Conditions: Hepatitis B, Chronic (CHB)
Interventions: BIOLOGICAL: Pegylated interferon alfa-2b (PegIntron)|DRUG: Adefovir dipivoxil (adefovir)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Test the Effect of an Experimental Mouth Rinse on Gum Disease
Status: WITHDRAWN
Conditions: Gingivitis
Interventions: DEVICE: Mouth Rinse 19668-012|DRUG: Mouth Rinse 500347078842|DRUG: Toothpaste 035000513007
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Travoprost, Investigational|DRUG: Travoprost (TRAVATAN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Esketamine on Postpartum Depression in Cesarean Section Women
Status: COMPLETED
Conditions: Esketamine|Postpartum Depression
Interventions: DRUG: Esketamine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Selective Serotonin Reuptake Inhibitors, Fluoxetine Versus the Standard Oral Desmopressin for Management of Mono-symptomatic Nocturnal Enuresis.
Status: ACTIVE_NOT_RECRUITING
Conditions: Nocturnal Enuresis|Enuresis|Enuresis, Nocturnal
Interventions: DRUG: Fluoxetine 20 MG|DRUG: Desmopressin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Coadministration of Ezetimibe With Fenofibrate Versus Pravastatin Monotherapy for the Treatment of Hyperlipidaemia in HIV-infected Patients
Status: UNKNOWN
Conditions: HIV|Hyperlipidemia|HIV Infections
Interventions: DRUG: ezetimibe|DRUG: fenofibrate|DRUG: pravastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploration Of Key Targets And Biomarkers Involved In An Allergic Response In Subjects With Allergic Rhinitis (Hay Fever)
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Fluticasone Propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Double-blind Study in Paediatric Epileptic to Compare the Subject Preference for ESL Suspension Formulation With Alternative Flavours
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: ESL Banana taste|DRUG: ESL Grape taste|DRUG: ESL Tutti-Frutti taste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Precision Cell Immunotherapy Combined With Chemotherapy in Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Precision Cell Immunotherapy|Chemotherapy|Advanced Malignancies
Interventions: DRUG: Chemotherapy|BIOLOGICAL: Precision Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of CSL112 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: CSL112 (reconstituted HDL)|BIOLOGICAL: normal saline (0.9%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Preladenant (MK-3814) Alone and With Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3814A-062)
Status: TERMINATED
Conditions: Neoplasm
Interventions: DRUG: preladenant|BIOLOGICAL: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Tivantinib on the QTC Interval in Cancer Subjects
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Tivantinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery
Status: RECRUITING
Conditions: Obesity|Pain, Postoperative
Interventions: DRUG: Dexmedetomidine|BEHAVIORAL: Person-centred care (PCC)|DRUG: Esketamine|DRUG: Lidocaine|DEVICE: Transcutaneous Nerve Stimulation (TENS)|DRUG: Remifentanil|DRUG: Desflurane|DRUG: Propofol|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-center Prospective Longitudinal Study of Taste in Patients With Cognitive Disorders at Different Stages of Severity (Isolated Cognitive Complaint, Minor or Major Neurocognitive Alzheimer-type Disorders) by Analysis of Gustatory Evoked Potentials
Status: RECRUITING
Conditions: Cognitive Disorders
Interventions: BIOLOGICAL: Blood samples|OTHER: Interviewing the subject and scales|OTHER: Neurocognitive evaluation|OTHER: Taste tests|OTHER: Computerized food preference questionnaires|OTHER: Nutritional status - body composition
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Capecitabine Versus S-1 as Adjuvant Therapy in Patients With Biliary Tract Carcinoma After Surgical Resection
Status: RECRUITING
Conditions: Biliary Tract Neoplasms|Recurrence|Cholangiocarcinoma|Gall Bladder Cancer
Interventions: DRUG: S-1|DRUG: Capecitabine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Immunogenicity and Safety of Two Recombinant Protein COVID-19 Vaccines in Population Aged ≥18 Years as Booster Vaccines
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19|SARS-CoV-2 Infection
Interventions: BIOLOGICAL: SCTV01C|BIOLOGICAL: SCTV01E|BIOLOGICAL: Sinopharm inactivated COVID-19 vaccine|BIOLOGICAL: Comirnaty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluate the Efficacy and Safety of Rosuvastatin Versus Simvastatin in Type 2 Diabetic Patients With Dyslipidemia
Status: COMPLETED
Conditions: Diabetes Mellitus|Dyslipidemia
Interventions: DRUG: Rosuvastatin|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Using the Drug Spironolactone to Test If It Reduces Protein Leakage From the Kidney
Status: COMPLETED
Conditions: Kidney Disease|Diabetic Nephropathy|Glomerulonephritis|Proteinuria
Interventions: DRUG: Spironolactone|DRUG: Irbesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Phase II Trial of Sunitinib in BAC or Never-Smokers With Any Lung Adenocarcinoma
Status: COMPLETED
Conditions: Lung Cancer|Adenocarcinoma
Interventions: DRUG: sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of PiQo4 for the Treatment of Hand Pigmentation Using 1064nm PSL and 532nm PSL
Status: UNKNOWN
Conditions: Pigmentation
Interventions: DEVICE: PiQo4 Laser System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia
Status: TERMINATED
Conditions: B-cell Childhood Acute Lymphoblastic Leukemia|Childhood Burkitt Lymphoma|Childhood Diffuse Large Cell Lymphoma|Childhood Immunoblastic Large Cell Lymphoma|L3 Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma
Interventions: DRUG: ifosfamide|DRUG: etoposide|BIOLOGICAL: rituximab|DRUG: carboplatin|BIOLOGICAL: filgrastim|DRUG: methotrexate|DRUG: cytarabine|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pain With Lidocaine-Mixed Radiesse® Injectable Dermal Filler
Status: COMPLETED
Conditions: Nasolabial Folds
Interventions: DEVICE: Radiesse® Injectable Dermal Filler Mixed with Lidocaine|DEVICE: Radiesse® Injectable Dermal Filler without Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Biofeedback-Based Cognitive Behavioral Treatment for Temporomandibular Disorders
Status: COMPLETED
Conditions: Temporomandibular Disorders
Interventions: BEHAVIORAL: Biofeedback-Based Cognitive Behavioral Treatment|DEVICE: Dental treatment with occlusal splint (OS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risk Education and Assessment for Cancer Heredity
Status: COMPLETED
Conditions: Breast Cancer|Ovarian Cancer|Genetic Predisposition
Interventions: BEHAVIORAL: Telephone Genetic Counseling|BEHAVIORAL: In-Person Genetic Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Navigated Repetitive Transcranial Magnetic Stimulation According to Post-stroke Aphasia Types
Status: COMPLETED
Conditions: To Healthy Volunteer|Virtual Lesions for Aphasia
Interventions: DEVICE: Repetitive magnetic stimulation to superior temporal gyrus|DEVICE: Repetitive magnetic stimulation to middle temporal gyrus|DEVICE: Repetitive magnetic stimulation (Sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block for Minimally Invasive Mitral Valve Surgery
Status: UNKNOWN
Conditions: Mitral Regurgitation|Mitral Valve Insufficiency|Mitral Valve Prolapse
Interventions: PROCEDURE: Erector spinae plane catheter with 0.5% Ropivacaine|PROCEDURE: Erector spinae plane catheter with saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Mechanism of Antidepressant-Related Dysfunctional Arousal in High-Risk Youth
Status: COMPLETED
Conditions: Depression|Anxiety|Bipolar Disorder
Interventions: DRUG: Escitalopram|BEHAVIORAL: Cognitive behavioral Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Study of the Pathogenesis and Cognitive Behavioral Group Therapy in Obsessive-Compulsive Disorder
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: BEHAVIORAL: cognitive behavioral group therapy|DRUG: sertraline, fluvoxamine|OTHER: cognitive behavioral group therapy and drug therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MCI: CPAP Treatment of OSA (Memories2)
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild Cognitive Impairment|Sleep Apnea, Obstructive
Interventions: DEVICE: CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outcome Study of the ReDO Intervention for Women With Stress-related Disorders
Status: COMPLETED
Conditions: Adjustment Disorders|Burnout, Professional
Interventions: BEHAVIORAL: Redesigning Daily Occupations|OTHER: Care as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Showering in 48-72 Hours of Median Sternotomy on Wound Infection, Pain, Comfort and Satisfaction
Status: COMPLETED
Conditions: Surgical Wound Infection
Interventions: OTHER: postoperative early shower
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Pilot Study of HSCT for Patients With High-risk Hemoglobinopathy Using a Nonmyeloablative Preparative Regimen
Status: COMPLETED
Conditions: Sickle Cell Disease|Thalassemia|Hemoglobinopathies
Interventions: OTHER: Busulfan; Fludarabine; cyclosporine A and MMF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Galactooligosaccharide, Immune Strength, and Digestive Health in Older Adults Over Cold and Flu Season
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Sucrose|DIETARY_SUPPLEMENT: Galactooligosaccharide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Bitopertin (RO4917838) in Combination With Selective Serotonin Reuptake Inhibitors (SSRIs) in Participants With Obsessive-Compulsive Disorder (OCD)
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: DRUG: Bitopertin|DRUG: Placebo|DRUG: SSRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Restart TICrH Alpha Pilot Protocol, Restarting DOACs After Traumatic Intracranial Hemorrhage
Status: UNKNOWN
Conditions: Anticoagulants; Increased
Interventions: DRUG: Apixaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Use of Chlorhexidine and a Probiotic Lozenge in the Nonsurgical Therapy of Periodontitis
Status: RECRUITING
Conditions: Periodontitis|Chlorhexidine|Probiotic
Interventions: COMBINATION_PRODUCT: active chlorhexidine and placebo probiotic|COMBINATION_PRODUCT: placebo chlorhexidine and active probiotic|COMBINATION_PRODUCT: active chlorhexidine and active probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Screening and Brief Intervention for Substance Misuse Following Traumatic Brain Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: Adapted Screening and Brief Intervention (Adapted SBI)|BEHAVIORAL: Screening & Education Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT