pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Prospective Evaluation of the Resection Margins and the Ganglionic Status Using a Quality Standard Resection for Adenocarcinoma of the Head of the Pancreas
Status: COMPLETED
Conditions: Pancreas|Adenocarcinoma
Interventions: PROCEDURE: resection of adenocarcinoma of the head of the pancreas
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Loteprednol Etabonate in an Ophthalmic Base vs Vehicle for the Treatment of Inflammation Following Cataract Surgery
Status: COMPLETED
Conditions: Ocular Inflammation
Interventions: DRUG: Loteprednol Etabonate|DRUG: Vehicle of Ophthalmic Loteprednol Etabonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Bone Mineral Density and Fracture Risk in Patients Receiving Androgen Deprivation Therapy for Prostate Cancer
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Bicalutamide and Calcium/ Vitamin D supplementation|DRUG: LHRH agonists (Goserelin acetate) and Calcium/ Vitamin D supplementation|DRUG: LHRH agonists (Goserelin acetate)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bilateral Erector Spinae Plane Block for Myofascial Pain Syndrome
Status: UNKNOWN
Conditions: Myofascial Pain Syndrome
Interventions: PROCEDURE: Bilateral thoracal erector spinae plane block|PROCEDURE: Trapezius muscle trigger point injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Think Dry: Optimalisation of Diagnostic Process of Urinary Incontinence in Older People
Status: RECRUITING
Conditions: Incontinence, Urge|Incontinence Stress|Incontinence, Daytime Urinary|Incontinence, Nighttime Urinary
Interventions: DIAGNOSTIC_TEST: Blood Sample|DIAGNOSTIC_TEST: Renal Function Profile|DIAGNOSTIC_TEST: Frequency Volume Chart|DIAGNOSTIC_TEST: Cystometry|DIAGNOSTIC_TEST: Questionaires|DIAGNOSTIC_TEST: Flow rate measurement + Observation of the post-void residual urine volume|DIAGNOSTIC_TEST: Clinical Examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reducing Adolescent Suicide Risk: Safety, Efficacy, and Connectome Phenotypes of Intravenous Ketamine
Status: ACTIVE_NOT_RECRUITING
Conditions: Adolescent Suicide|Adolescent Depression
Interventions: DRUG: Ketamine Infusion|DRUG: Midazolam Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Thalidomide in Preventing Chemotherapy-induced Delayed Nausea and Vomiting
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Thalidomide|DRUG: Placebo for thalidomide|DRUG: Palonosetron and Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety & Feasibility of PERIsign System in Demonstrating Involuntary Muscle Defense as a Sign of Peritonitis in Subjects With Appendicitis
Status: RECRUITING
Conditions: Appendicitis Acute|Appendicitis|Abdominal Pain|Peritonitis
Interventions: DEVICE: PERIsign examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Urinary Aquaporine 2 in Patients With Syndrome of Inappropriate ADH-secretion Caused by Treatment With Antiepileptic Medicine
Status: WITHDRAWN
Conditions: Syndrome of Inappropriate ADH-secretion
Interventions: PROCEDURE: fluid restriction for 14 days (15ml fluid per kg weight)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: A Prospective Feasibility Study Evaluating Extracellular Vesicles Obtained by Liquid Biopsy for Neoadjuvant Treatment Response Assessment in Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer|Liquid Biopsy
Interventions: PROCEDURE: Supplementary blood samples collection during the normal follow up of the patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Depakote Monotherapy, Olanzapine Monotherapy, and Combination Therapy of Depakote Plus Olanzapine in Stable Subjects During the Maintenance Phase of Bipolar Illness
Status: TERMINATED
Conditions: Bipolar Disorder
Interventions: DRUG: Divalproex Sodium (Delayed-Release Tablets)|DRUG: Divalproex Sodium (Extended-Release Tablets)|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Celecoxib as a Post-tonsillectomy Pain Medication
Status: COMPLETED
Conditions: Tonsillitis
Interventions: DRUG: Celecoxib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Different Storage Conditions on Removable Retainers
Status: RECRUITING
Conditions: Orthodontic Appliance Complication
Interventions: DEVICE: Hawley retainers in dry storage condition|DEVICE: Hawley retainers in wet storage condition|DEVICE: VFRs in dry storage condition|DEVICE: VFRs in wet storage condition|DEVICE: Baseline characteristics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Efficacy and Mechanism of FSN Treatment for Senile Knee Osteoarthritis
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Fu's Subcutaneous Needling|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proof of Activity Study of UR-63325 in Allergic Rhinitis Induced by Nasal Challenge
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: UR-63325|DRUG: Fluticasone propionate nasal spray|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IMProving Executive Function Study
Status: COMPLETED
Conditions: Cognitive Impairment|RRSO
Interventions: DRUG: Lisdexamfetamine|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MINIject 636 in Patients With Open Angle Glaucoma Uncontrolled by Topical Hypotensive Medications
Status: COMPLETED
Conditions: Open Angle Glaucoma
Interventions: DEVICE: MINI DO636|DEVICE: MINI SO636
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Rapid Pathogen Detection in ICU Patients With Suspected Pneumonia on Antimicrobial Therapy
Status: RECRUITING
Conditions: Pneumonia|Critically Ill
Interventions: DIAGNOSTIC_TEST: FA Pneumonia Panel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Passive and Active Rest Break in Musculoskeletal Complains
Status: COMPLETED
Conditions: Occupational Diseases|Work-related Injury
Interventions: OTHER: Shiatsu massage|OTHER: Physical Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity of High-dose Inactivated, Split-virion Influenza Vaccine Versus Standard Fluzone Vaccine in the Elderly
Status: COMPLETED
Conditions: Orthomyxoviridae Infection|Influenza|Myxovirus Infection
Interventions: BIOLOGICAL: High-Dose Inactivated, Split-Virion Influenza Vaccine|BIOLOGICAL: High-Dose Inactivated, Split-Virion Influenza Vaccine|BIOLOGICAL: High-Dose Inactivated, Split-Virion Influenza Vaccine|BIOLOGICAL: Inactivated, Split-Virion Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections
Status: COMPLETED
Conditions: Ascariasis|Trichuriasis|Hookworm Infection|Strongyloidiasis|Pediculosis
Interventions: DRUG: albendazole vs. combined albendazole/ivermectin treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: HEROES: Human Extremity Robotic Rehabilitation and Outcome Enhancement for Stroke
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: DEVICE: Brain-Computer Interface control of robotic arms with augmented reality|DEVICE: Serious game with augmented reality
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Laparoscopic Enclosed Morcellation; Electromechanic Morcellation vs Vaginal Removal
Status: COMPLETED
Conditions: Myoma
Interventions: PROCEDURE: Enclosed morcellation|PROCEDURE: vaginal morcellation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Lenvatinib (E7080) in Participants With Advanced Hepatocellular Carcinoma (HCC)
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fructose and Fructans in Irritabla Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Glucose|DIETARY_SUPPLEMENT: Fructose|DIETARY_SUPPLEMENT: Fructans
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacokinetics of Single Doses of BILR 355 BS Given With Ritonavir in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BILR 355 BS, D1|DRUG: BILR 355 BS, D2|DRUG: BILR 355 BS, D3|DRUG: BILR 355 BS, D4|DRUG: BILR 355 BS, D5|DRUG: BILR 355 BS, D6|DRUG: BILR 355 BS, D7|DRUG: BILR 355 BS, D8|DRUG: BILR 355 BS, D10|DRUG: Placebo|OTHER: high-fat breakfast|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Biological Therapy in Treating Patients With Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: anti-thymocyte globulin|BIOLOGICAL: etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: PET/MR Assessment of Sipuleucel T Treatment for Metastatic Castration Resistant Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DEVICE: PET/CT|DEVICE: PET/MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: AZELASTINE/FLUTICASONE (AZE/FLU) Nasal Spray on Symptom Control, Nasal Mediators and Nasal Hyperresponsiveness in Allergic Rhinitis (AR)
Status: UNKNOWN
Conditions: Allergic Rhinitis|House Dust Mite Allergy
Interventions: DRUG: azelastine + fluticasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Computer-Assisted Stop-Smoking Program in Helping Doctors Counsel Patients Who Smoke Cigarettes
Status: UNKNOWN
Conditions: Tobacco Use Disorder
Interventions: BEHAVIORAL: computer-assisted smoking cessation intervention|OTHER: cancer prevention|OTHER: educational intervention|OTHER: survey administration
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Anesthesia Quality Improvement and Patients With Planned ICU Admission
Status: NOT_YET_RECRUITING
Conditions: Anesthesia|Extubation|Intensive Care Unit|Postoperative Complications
Interventions: OTHER: Routine anesthesia care|OTHER: Improved anesthesia care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: "Fetal gRowth AbnorMality dEtection Trial"
Status: UNKNOWN
Conditions: Small for Gestational Age Infant|Large for Gestational Age Infant|Oligohydramnios|Polyhydramnios
Interventions: OTHER: Point of care ultrasound to measure the fetal abdominal circumference (POC-US-AC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: IBD Disease Course of Infliximab-naïve IBD Patients Treated With Subcutaneous Infliximab CT-P13 Remsima®
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases
Interventions: OTHER: Biocollection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Chemotherapy Plus Radiation Therapy and Biological Therapy in Treating Patients With Hematologic Cancer
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: DRUG: cyclophosphamide|PROCEDURE: allogeneic bone marrow transplantation|RADIATION: low-LET cobalt-60 gamma ray therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Targeted PCR and Acute Endophthalmitis
Status: UNKNOWN
Conditions: Acute Endophthalmitis Post-operative
Interventions: BIOLOGICAL: PCR : 16S ribosomal DNA and real-time targeted PCR|BIOLOGICAL: Sampling of aqueous humour
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Radial Versus Femoral Access For Carotid Artery Stenting
Status: UNKNOWN
Conditions: Ischemic Stroke|Carotid Stenosis|Cerebral Revascularization|Carotid Artery Diseases
Interventions: PROCEDURE: Carotid Artery Stenting (CAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug-drug Interaction Study to Evaluate the Effect of Rifampicin on the Pharmacokinetics of Methotrexate in Elderly Subjects
Status: ENROLLING_BY_INVITATION
Conditions: Drug Interactions
Interventions: DRUG: Methotrexate Sodium|DRUG: Rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: When Closing Midline Incisions, do Small Stitches Reduce the Risk for Incisional Hernia, Wound Infection or Dehiscence?
Status: COMPLETED
Conditions: Wound Infection|Incisional Hernia|Wound Dehiscence
Interventions: PROCEDURE: Small stitches|PROCEDURE: Mass closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Phase II Study of Faropenem in the Treatment of Adult Community-acquired Bacterial Pneumonia
Status: COMPLETED
Conditions: Community Acquired Pneumonia
Interventions: DRUG: Faropenem（high dose group）|DRUG: Faropenem（low-dose group)|DRUG: Ertapenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Compare the Safety and Efficacy of "HG-102" With Botox® in the Improvement of Moderate to Severe Glabellar Lines.
Status: COMPLETED
Conditions: Glabellar Lines
Interventions: DRUG: Botulinum Toxin Type A Injection [Botox]|DRUG: Botulinum toxin type A injection [HG-102]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Physical Therapy Modalities in Osteoarthritis
Status: COMPLETED
Conditions: Osteo Arthritis Knee|Quadriceps Muscle Atrophy
Interventions: OTHER: Dry Needling|OTHER: Kinesio tapping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: YL-1 Needle Puncture vs BHC With Postoperative Exhaustive Drainage for CSDH
Status: RECRUITING
Conditions: Chronic Subdural Hematoma
Interventions: PROCEDURE: Burr Hole Craniostomy and Postoperative Exhaustive Drainage Strategy|PROCEDURE: YL-1 puncture needle and Postoperative Exhaustive Drainage Strategy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Using Irrigations at Different Temperatures on Postoperative Period During the Extraction of Impacted Mandibular Molars
Status: COMPLETED
Conditions: Impacted Third Molar Tooth
Interventions: PROCEDURE: saline irrigation at various temperatures (4°C, 25°C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Helminth Infection During Pregnancy on Vitamin D Regulation: HELMVIT Study
Status: COMPLETED
Conditions: Vitamin D Deficiency|Immunosuppression
Interventions: DIAGNOSTIC_TEST: Microscopy ( Urine filtration), UCAA test, qPCR,|DIAGNOSTIC_TEST: Microscopy (Kato Katz, Coproculture, Harada Mori, MIF), qPCR,
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Study of SU 11248 (Sutent) Combined With Standard Chemotherapy in Patients With FLT3 Mutated AML Over 60 Years
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antimicrobial Susceptibility Testing Guided Triple Therapy in Salvage Helicobacter Pylori Treatment
Status: UNKNOWN
Conditions: Antimicrobial Susceptibility Testing|Triple Therapy
Interventions: DRUG: amoxicillin|DRUG: clarithromycin|DRUG: tinidazole|DRUG: levofloxacin|DRUG: furazolidone|DRUG: tetracycline|DRUG: Ilaprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Fatty Acids in Chronic Periodontitis.
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: DRUG: Omega 3 fatty acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Quality Improvement Process to Support Delivery of Cardiovascular Care in Community Mental Health Organizations
Status: COMPLETED
Conditions: Diabetes Mellitus|Hypertension|Dyslipidemias
Interventions: OTHER: Comprehensive Unit Based Safety Program (CUSP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Low Dose Estriol With Lactobacilli Treatment for Preventing Recurrent Urinary Tract Infection in Postmenopausal Women
Status: UNKNOWN
Conditions: Urinary Tract Infections
Interventions: DRUG: Gynoflor E (low dose estriol with lactobacillus)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ventilatory Influence on Cerebral Oxygenation During VATS
Status: COMPLETED
Conditions: Thoracic Diseases
Interventions: DIAGNOSTIC_TEST: Monitoring of regional cerebral oxygenation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Salvage Radiation Therapy in Treating Patients With Metastatic Cancer That Has Progressed After Systemic Immunotherapy
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Metastatic Malignant Solid Neoplasm
Interventions: RADIATION: External Beam Radiation Therapy|OTHER: Laboratory Biomarker Analysis|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Medtronic TAVR 2.0 US Clinical Study
Status: COMPLETED
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: Medtronic Transcatheter Aortic Valve 2.0 Replacement System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contact Radiotherapy for Rectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Rectal Cancer
Interventions: RADIATION: Radiotherapy|RADIATION: Short-course radiotherapy|RADIATION: Contact x-ray brachytherapy|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study Of Panobinostat/Lenalidomide/Bortezomib/Dex for Relapsed And Relapsed/Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma in Relapse
Interventions: DRUG: Panobinostat|DRUG: Dexamethasone|DRUG: Lenalidomide|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Celecoxib, Irinotecan and Concurrent Radiotherapy in Preoperative Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: celecoxib|DRUG: irinotecan|PROCEDURE: concurrent radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treosulfan/Fludarabine/Low Dose TBI as a Preparative Regimen for Children With AML/MDS Undergoing Allo HCT
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome (MDS)
Interventions: DRUG: Treosulfan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retraining Walking After Spinal Cord Injury
Status: UNKNOWN
Conditions: Spinal Cord Injuries|Quadriplegia|Paraplegia|Central Cord Syndrome|Brown-Sequard Syndrome
Interventions: BEHAVIORAL: Locomotor treadmill training with body weight support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 68Ga-FAPI-FS PET/CT and PET/MR in Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DIAGNOSTIC_TEST: 68Ga-FAPI-FS PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Safety and Efficacy Study of Tavilermide (MIM-D3) Ophthalmic Solution for the Treatment of Dry Eye
Status: COMPLETED
Conditions: Keratoconjunctivitis Sicca
Interventions: DRUG: 1% Tavilermide Ophthalmic Solution|DRUG: Placebo Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Apremilast Pediatric Study in Children With Active Juvenile Psoriatic Arthritis
Status: RECRUITING
Conditions: Active Juvenile Psoriatic Arthritis
Interventions: DRUG: Apremilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Abuse Potential of Seltorexant Compared to Suvorexant and Zolpidem
Status: COMPLETED
Conditions: Healthy Non-dependent, Recreational Sedative Users|Abuse Potential
Interventions: DRUG: Suvorexant|DRUG: Zolpidem|DRUG: Seltorexant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Cost-effectiveness of a Tailored Text Message Programme (MiQuit) for Smoking Cessation in Pregnancy
Status: COMPLETED
Conditions: Smoking Cessation|Pregnancy Related
Interventions: OTHER: MiQuit text message support programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Transition to Infant Formula Feeding on Gastrointestinal Regurgitation (TIGER) Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastrointestinal Disorder, Functional|Regurgitation, Gastric|Colic, Infantile|Constipation - Functional|Infant Development
Interventions: DIETARY_SUPPLEMENT: Infant formula based on whole goat milk|DIETARY_SUPPLEMENT: infant formula based on cow milk proteins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optimal End-Tidal (ET) Sevoflurane and Desflurane Concentration for Extubation of Supreme Laryngeal Mask Airway (LMA) in Adults
Status: COMPLETED
Conditions: Airway Complications
Interventions: DRUG: Sevoflurane|DRUG: Desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prophylactic Closed Incision Negative Pressure Wound Therapy on Abdominal Wounds - Clinical and Economic Perspectives
Status: WITHDRAWN
Conditions: Wound Infection|Surgical Site Infection|Surgical Wound|Surgical Incision
Interventions: OTHER: Wound dressings: Conservative dressings|OTHER: Wound dressings: Prevena dressings|OTHER: Wound dressings: ciVAC dressings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of the Effects of Access Count in Percutaneous Nephrolithotomy on Renal Functions by Technetium-99M-Dimercaptosuccinic Acid Scintigraphy
Status: COMPLETED
Conditions: Renal Parenchymal Loss After the Percutaneous Nephrolithotomy
Interventions: PROCEDURE: Percutaneous nephrolithotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Randomized, Double-Blind Study to Evaluate Efficacy and Safety of Cenobamate Adjunctive Therapy in PGTC Seizures
Status: RECRUITING
Conditions: Primary Generalized Epilepsy
Interventions: DRUG: Cenobamate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Versus E2020 10mg Followed by an Open-label Extension Phase to Explore the Safety of E2020 SR 23 mg in Japanese Subjects With Severe Alzheimer's Type Dementia
Status: COMPLETED
Conditions: Alzheimer's Type Dementia
Interventions: DRUG: E2020|DRUG: E2020
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Contribution of Narrow Band Imaging (NBI) for the Characterization of Scalloped Polyps (NBI POLYPES COLIQUES)
Status: TERMINATED
Conditions: Polyps of Colon
Interventions: OTHER: Colonoscopy with NBI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Exercise Training in Dialysis Patients With Restless Legs Syndrome (RLS)
Status: COMPLETED
Conditions: Restless Legs Syndrome|End Stage Renal Disease|Hemodialysis|Muscle Cachexia|Sleep Disorders
Interventions: OTHER: Dopamine Agonist and Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Long-term Use of Proton Pump Inhibitors May Cause Vitamin B12 Deficiency in the Institutionalized Elderly
Status: COMPLETED
Conditions: Vitamin B12 Deficiency
Interventions: OTHER: blood collection|DRUG: treatment (cyanocobalamin nasal spray)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sunitinib and Gemcitabine in Treating Patients With Pancreatic Cancer or Other Solid Tumors
Status: COMPLETED
Conditions: Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage III Pancreatic Cancer|Stage IV Pancreatic Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: sunitinib malate|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK/PD Study of Vicagrel and Clopidogrel in Healthy Subjects With Different CYP2C19 Metabolizers
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: vicagrel Capsules|DRUG: Clopidogrel Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BIO-11006 in the Treatment of Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer Stage IIIB
Interventions: DRUG: BIO-11006 plus standard of care|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Effects of Posterior Mobilization Versus Caudal Mobilization in Patients With Temporomandibular Disorders
Status: COMPLETED
Conditions: Temporomandibular Disorders
Interventions: PROCEDURE: POSTERIOR MOBILIZATION|PROCEDURE: CAUDAL MOBILIZATION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Compare Videolaryngoscope Against Direct Laryngoscope for Intubation When Powered Air Purifying Respirator is Worn
Status: COMPLETED
Conditions: Coronavirus Infection|Ventilatory Failure|Anesthesia Intubation Complication
Interventions: DEVICE: McGrath videolaryngoscope|DEVICE: Direct laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke
Status: NOT_YET_RECRUITING
Conditions: Stroke|Cerebellum
Interventions: BEHAVIORAL: Neural responses to speech functional localizer|BEHAVIORAL: Neural responses to silent articulation|BEHAVIORAL: Neural responses to self vs. externally generated speech|BEHAVIORAL: Event-related potentials for speech|BEHAVIORAL: Neural responses to induced speech errors|BEHAVIORAL: Neural responses to sensory-motor adaptation|BEHAVIORAL: Speech production behaviors|BEHAVIORAL: Auditory acuity testing|BEHAVIORAL: Neural responses to learning a non-speech auditory motor behavior
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Safety and Preliminary Efficacy Study of CC-99282, Alone and in Combination With Anti-lymphoma Agents in Participants With Relapsed or Refractory Non-Hodgkin Lymphomas (R/R NHL)
Status: RECRUITING
Conditions: Lymphoma, Non-Hodgkin
Interventions: DRUG: CC-99282|DRUG: Rituximab|DRUG: Obinutuzumab|DRUG: Tafasitamab|DRUG: Valemetostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of CART-19 Cells in B-cell Acute Lymphoblastic Leukemia (B-ALL).
Status: UNKNOWN
Conditions: B-cell Acute Lymphoblastic Leukemia
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|BIOLOGICAL: CART-19 cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visual and Tactile Scanning Training in Patients With Neglect After Stroke
Status: UNKNOWN
Conditions: Hemispatial Neglect
Interventions: OTHER: Visual and tactile scanning training|OTHER: Uni-modal visual scanning training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bone Formed Labial to the Implant in Relation to the Horizontal Gap Dimension in Immediate Implant Placement.
Status: NOT_YET_RECRUITING
Conditions: Immediate Implant Placement
Interventions: PROCEDURE: Virtual implant placement following safe angle concept|PROCEDURE: actual implant placement following safe angle concept
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dynamic Ultrasonography VS MRI in the Evaluation of Meniscal Lesions in Patients With an Indication for Arthroscopy
Status: RECRUITING
Conditions: Meniscus Lesion|Meniscus Disorder|ACL Injuries
Interventions: DIAGNOSTIC_TEST: Dynamic Ultrasonography assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessment of the Clinical Effectiveness of a Herbal Extract (Cretan IAMA) in Patients With Viral Respiratory Infections, Including COVID-19, in Primary Healthcare Settings, and Co-assessment of Its Prophylactic Effect in People Cohabiting With These Patients
Status: COMPLETED
Conditions: Covid19|Viral Infection|Respiratory Viral Infection
Interventions: DIETARY_SUPPLEMENT: Cretan IAMA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Breathing Exercise and Stabilization Exercise With Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain|Sleep Hygiene|Anxiety
Interventions: DEVICE: Conventional physical therapy|OTHER: Lumbar stabilization exercises|OTHER: Breathing exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Illizarov Fixation in Open Type III (A&B) Pediatric and Adolescent Tibial Shaft Fractures
Status: UNKNOWN
Conditions: Open Type III (A&B)Pediatric and Adolescent Tibial Shaft Fractures|Ilizarov Fixation
Interventions: PROCEDURE: Ilizarov
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety and Efficacy of K-321 Eye Drops After Simultaneous Cataract Surgery and Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD)
Status: RECRUITING
Conditions: Fuchs Endothelial Corneal Dystrophy
Interventions: DRUG: Ripasudil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive and Aerobic Resilience for the Brain
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Combined Cognitive and Physical|BEHAVIORAL: Cognitive|BEHAVIORAL: Physical|BEHAVIORAL: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: (2R,6R)-Hydroxynorketamine for the Treatment of Neuropathic Pain
Status: NOT_YET_RECRUITING
Conditions: Pain, Neuropathic
Interventions: DRUG: Ketamine|DRUG: (2R,6R)-hydroxynorketamine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Veramyst and Olopatadine 0.2% Opthalmic Solution on Allergy Symptoms
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: PL nasal spray|DRUG: fluticasone furoate (FF)|DRUG: PL eye drops|DRUG: olopatadine (OLO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Phase 1b Safety and Efficacy Study of TRU-016
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia|Peripheral T-cell Lymphoma
Interventions: BIOLOGICAL: 20 mg/kg TRU-016 + Rituximab|BIOLOGICAL: 10 mg/kg TRU-016 + Rituximab|BIOLOGICAL: TRU-016 20 mg/kg + Obinutuzumab|BIOLOGICAL: TRU-016 6-20 mg/kg + idelalisib + rituximab|BIOLOGICAL: TRU-016 10-20 mg/kg + ibrutinib|BIOLOGICAL: TRU-016 10-20 mg/kg + bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Crossover Pharmacokinetic Evaluation of Subcutaneous Versus Intravenous Granisetron in Cancer Patients
Status: COMPLETED
Conditions: Vomiting
Interventions: DRUG: granisetron
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Hydrocortison on Post-ischemic Flow-mediated Dilation and on Thenar Oxygen Saturation in Human Septic Shock.
Status: TERMINATED
Conditions: Septic Shock|Adult
Interventions: DRUG: hydrocortison hemisuccinate|DRUG: placebo followed by hydrocortisone hemisuccinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SPI-1005 for Prevention and Treatment of Chemotherapy Induced Hearing Loss
Status: UNKNOWN
Conditions: Lung Cancer|Head and Neck Cancer|Hearing Loss|Ototoxicity|Tinnitus|Neuropathy
Interventions: DRUG: SPI-1005 Low Dose|DRUG: SPI-1005 Middle Dose|DRUG: SPI-1005 High Dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation and Safety Study of I5NP to Prevent Acute Kidney Injury (AKI) in Patients at High Risk of AKI Undergoing Major Cardiovascular Surgery (QRK.004)
Status: TERMINATED
Conditions: Acute Renal Failure|Acute Kidney Injury
Interventions: DRUG: I5NP|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of JNJ-404118413 in Healthy Male Patients
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-40411813|DRUG: Placebo|DRUG: Citalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: The Effectiveness of Hydroxychloroquine Versus Methotrexate in the Treatment of Lichen Planopilaris in Routine Clinical Care: a Patient Preference Trial
Status: RECRUITING
Conditions: Lichen Planopilaris|Cicatricial Alopecia
Interventions: DRUG: Hydroxychloroquine|DRUG: Methotrexate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Decision Aids in Cerebral Aneurysm Treatment
Status: WITHDRAWN
Conditions: Cerebral Aneurysm
Interventions: BEHAVIORAL: Option grid for cerebral aneurysm treatment|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Effect of Doxycycline Verses Placebo on Retinal Function and Diabetic Retinopathy
Status: COMPLETED
Conditions: Diabetic Retinopathy
Interventions: DRUG: doxycycline monohydrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TactiCath Contact Force Ablation Catheter Study for Atrial Fibrillation
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: Catheter ablation to treat paroxysmal atrial fibrillation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Body Mass Index on Erector Spinae Plane Block Analgesia
Status: COMPLETED
Conditions: Pain|Pain Postoperative|Pain Acute|Erector Spinae Plane Block|Lumbar Disc Herniation|Body Mass Index
Interventions: PROCEDURE: Erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Dose Escalation Trial of Afatinib Plus Gemcitabine or Plus Docetaxel
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Afatinib|DRUG: Afatinib|DRUG: docetaxel|DRUG: gemcitabine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Safety of Weekly Subcutaneous Pegzilarginase in Subjects With Arginase 1 Deficiency
Status: TERMINATED
Conditions: Arginase I Deficiency|Hyperargininemia
Interventions: DRUG: Pegzilarginase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Cervical Stabilization Exercises on Proprioception and Hand Grip Strength in Sedentary Office Workers
Status: NOT_YET_RECRUITING
Conditions: Cervical Pain
Interventions: OTHER: cervical stabilization exercises|DEVICE: Ultrasound therapy|OTHER: traditional treatment program|DEVICE: Infrared therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS)
Status: UNKNOWN
Conditions: Acute Respiratory Distress Syndrome (ARDS)|Hypovolemia|Pulmonary Edema
Interventions: DRUG: 4% albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Intermittent Fasting on Polycystic Ovary Syndrome (PCOS) Compared to Standard Treatment
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Insulin Resistance
Interventions: BEHAVIORAL: Time restricted eating
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project THRIVE: Evaluating Different Approaches to Dietary Self-Monitoring for Weight Loss
Status: COMPLETED
Conditions: Obesity|Overweight
Interventions: BEHAVIORAL: Reduced Frequency Self-Monitoring|BEHAVIORAL: Full-Frequency Self-Monitoring|BEHAVIORAL: Standard Behavioral Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral Science and Hepatitis C Screening Outreach
Status: COMPLETED
Conditions: Hepatitis C
Interventions: BEHAVIORAL: Opt-Out|BEHAVIORAL: Letter|BEHAVIORAL: Behavioral Economic Messaging|BEHAVIORAL: Usual Care Messaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: A Study of V110 a Pneumococcal Vaccine in Healthy Adults (V110-013)
Status: COMPLETED
Conditions: Healthy|Pneumococcal Infections
Interventions: BIOLOGICAL: V110, pneumococcal vaccine polyvalent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for Sleep Disturbances in OEF/OIF Veterans With Post Traumatic Stress Disorder
Status: COMPLETED
Conditions: Post Traumatic Stress Disorder|Sleep Disturbance
Interventions: DEVICE: Auricular Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Efficacy and Safety of Levothyroxine in Brain Death Organ Donors: a Randomized Controled Trial
Status: TERMINATED
Conditions: Brain Dead Organ Donors
Interventions: DRUG: Levothyroxine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of a New Technology for the Treatment of Bladder Leakage in Women
Status: TERMINATED
Conditions: Urinary Incontinence|Urinary Incontinence, Stress|Urinary Incontinence, Urge
Interventions: DEVICE: Electrical stimulation|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Microbiome in Recurrent Obesity
Status: NOT_YET_RECRUITING
Conditions: Obesity|Weight Loss|FMT
Interventions: OTHER: Fecal microbiota transplantation (FMT)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: L-carnitine as an Adjunct Treatment for Septic Shock Patients With Acute Kidney Injury
Status: RECRUITING
Conditions: Severe Sepsis|Shock, Septic|Acute Kidney Injury
Interventions: DRUG: 56 days of weight-adjusted L-Carnitine treatment|DRUG: 10 days of intravenous placebo (isotonic saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Mental Health Following Early PREgnancy Loss Using a Brief Cognitive Task
Status: UNKNOWN
Conditions: Post-traumatic Stress Disorder|Miscarriage|Ectopic Pregnancy|Pregnancy Loss|Trauma, Psychological
Interventions: BEHAVIORAL: Brief cognitive task-based intervention|BEHAVIORAL: Placebo activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION