pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Is Spontaneous Bacterial Peritonitis Still Responding to 3rd Generation Cephalosporins?
Status: UNKNOWN
Conditions: Primary Bacterial Peritonitis
Interventions: DRUG: Cefotaxime|DRUG: ceftriaxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of In-situ Thrombolysis in Case of Intraventricular Haemorraghia by Aneurysm Rupture
Status: COMPLETED
Conditions: Aneurysm, Ruptured|Subarachnoid Hemorrhage
Interventions: PROCEDURE: fibrinolysis in situ|PROCEDURE: drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Social Media Intervention on Promoting Oral Heath Among Iranian Adolescents
Status: COMPLETED
Conditions: Health Behavior|Adolescent Behavior|Parent-Child Relations
Interventions: BEHAVIORAL: mothers and adolescents|BEHAVIORAL: adolescents|BEHAVIORAL: active control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Genes in Predicting Outcome of Patients With DLBCL Treated With Rituximab and Combination Chemotherapy (R-CHOP)
Status: TERMINATED
Conditions: Lymphoma
Interventions: DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Prednisone|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Propranolol Versus Acebutolol on the Proliferative Phase of Infantile Hemangioma
Status: TERMINATED
Conditions: Hemangioma
Interventions: DRUG: Acebutolol|DRUG: Propanolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gene Therapy-Treated Stem Cells in Treating Patients Undergoing Stem Cell Transplant for Intermediate-Grade or High-Grade AIDS-Related Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: lentivirus vector rHIV7-shI-TAR-CCR5RZ-transduced hematopoietic progenitor cells|DRUG: carmustine|DRUG: cyclophosphamide|DRUG: etoposide|PROCEDURE: autologous hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MEDUSA Study - Migraine: Evaluation of Diagnosis, Utilisation of Services and Application
Status: COMPLETED
Conditions: Migraine|Self-Assessment
Interventions: DEVICE: N1-Headache App (by Curelator)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Placebo-controlled Study for SPM 962 in Early Parkinson's Disease Patients
Status: COMPLETED
Conditions: Early Parkinson's Disease
Interventions: DRUG: SPM 962|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Multiple Intravitreal Injection TK001 in Patients With Neovascular Age-related Macular Degeneration
Status: UNKNOWN
Conditions: Neovascular Age-Related Macular Degeneration
Interventions: BIOLOGICAL: TK001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of a Humanized Antibody Initiated 2 Months After an HLA Matched Allogenic Stem Cell Transplantation
Status: UNKNOWN
Conditions: Hematologic Malignancies
Interventions: DRUG: Monalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Alendronate After Cure of Primary Hyperparathyroidism
Status: WITHDRAWN
Conditions: Hyperparathyroidism
Interventions: DRUG: Alendronate 70mg weekly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MIcrodoses of raNIbizumab in Diabetic MAcular Edema (MINIMA-2)
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Ranibizumab 0.05mg|DRUG: Ranibizumab 0.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dose-escalation, and Safety Study of LDE225 and Gemcitabine in Locally Advanced or Metastatic Pancreatic Cancer Patients
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: LDE225+gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blood Flow Restricted Electrical Stimulation During Immobilisation
Status: UNKNOWN
Conditions: Atrophy, Muscular|Atrophy, Disuse
Interventions: OTHER: Neuromuscular electrical stimulation with blood flow restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A 6 Month, Open-Label, Pilot Futility Clinical Trial of Oral Salsalate for Progressive Supranuclear Palsy
Status: COMPLETED
Conditions: Progressive Supranuclear Palsy
Interventions: DRUG: Salsalate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-related Effect of Aspirin on Laboratory-defined Acetylsalicylic Acid Resistance and Clinical Outcome After Coronary Stenting
Status: COMPLETED
Conditions: Coronary Stenting
Interventions: DRUG: 80 mg ASA dosing|DRUG: 500 mg ASA dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Idronoxil Suppository Combine With Radiotherapy for Metastatic Prostate Cancer
Status: TERMINATED
Conditions: Metastatic Castrate- Resistant Prostate Cancer
Interventions: DRUG: idronoxil (NOX66) suppository|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Emergency Medicine Palliative Care Access
Status: COMPLETED
Conditions: Advanced Cancer|End Stage Organ Failure
Interventions: BEHAVIORAL: Nurse-led telephonic case management|BEHAVIORAL: Facilitated,outpatient specialty palliative care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: High-Intensity Interval Versus Moderate-Intensity Continuous Water Based Exercise in Hypertensive Older Individuals
Status: UNKNOWN
Conditions: Hypertension
Interventions: OTHER: High Intensity Interval Exercise in Heated Water-Based|OTHER: Continuous Moderate Exercise in Heated Water-Based|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preventive Effects of Bosentan on the Systemic Cardiovascular Consequence of Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Hypertension
Interventions: DRUG: bosentan|DEVICE: nasal continuous positive airway pressure (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Osteopathy Treatment and Cardiovascular Recovery After a Rugby Match
Status: COMPLETED
Conditions: Cardiovascular Physiological Phenomena
Interventions: OTHER: Osteopathic manipulative treatment|OTHER: Sham treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Tracer in the Sentinel Node Procedure in Breast Cancer: the Non-radioactive Alternative for Radio-isotopes
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: MagSeed and MagTrace in breast cancer patiënts
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Regorafenib Combined With Best Supportive Care as Maintenance Treatment in High Grade Bone Sarcomas Patients
Status: RECRUITING
Conditions: Bone Sarcoma|Osteosarcoma
Interventions: DRUG: Treatment by regorafenib and best supportive care|DRUG: Treatment by placebo and best supportive care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Clinical Effectiveness of Pulsed Electromagnetic Field Therapy on the Management of Chronic Ankle Instability
Status: RECRUITING
Conditions: Chronic Ankle Instability
Interventions: DEVICE: PEMF device, Quantum Tx, Singapore|OTHER: Standard rehabilitation and sham PEMF therapy for CAI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimized Bismuth Quadruple Therapy vs Triple Standard Therapy for Helicobacter Pylori Eradication
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Optimized bismuth quadruple therapy|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Deep TMS for the Treatment of Patients With Parkinson's Disease and Progressive Supranuclear Palsy
Status: COMPLETED
Conditions: Progressive Supranuclear Palsy|Parkinson's Disease
Interventions: DEVICE: active Deep TMS|DEVICE: sham Deep TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Respiratory Variation in Central Venous Oxygen Saturation Predicts Volume Responsiveness in Hemodynamically Unstable Patients Under Mechanical Ventilation : a Prospective Cohort Study
Status: COMPLETED
Conditions: Hemodynamic Instability
Interventions: DRUG: Sodium Chloride 0.9% Intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weaning Algorithm for Mechanical VEntilation
Status: UNKNOWN
Conditions: Respiration, Artificial|Critical Care|Respiratory Insufficiency|Intensive Care (ICU) Myopathy|Mechanical Ventilation Complication
Interventions: DEVICE: Beacon Care System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: OPTIM DASATINIB (Optimized Tyrosine Kinase Inhibitors Monotherapy)
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia, BCR/ABL Positive
Interventions: DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Praxis Evaluation of a Pain Self-management Support Intervention for Oncology Patients: A Stepped Wedge Design Study
Status: COMPLETED
Conditions: Cancer Pain Self-management
Interventions: BEHAVIORAL: ANtiPain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: JY231 Injection in the Treatment of Relapsed or Refractory B-cell Lymphoma
Status: RECRUITING
Conditions: Relapsed or Refractory B-cell Lymphoma
Interventions: BIOLOGICAL: infusion of JY231 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of FOLFOX4+Panitumumab vs.FOLFIRI+Panitumumab in Subjects WT KRAS Colorectal Cancer and Liver-only Metastases
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Panitumumab+FOLFOX-4|DRUG: Panitumumab+FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Velcade and Eloxatin for Patients With Malignant Pleural or Peritoneal Mesothelioma
Status: UNKNOWN
Conditions: Mesothelioma
Interventions: DRUG: Velcade (bortezomib) plus Eloxatin (oxaliplatin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Artificial Intelligence (AI) Empowered Smile Simulations: Do They Accurately Predict Actual Post Treatment Outcomes
Status: COMPLETED
Conditions: Malocclusion
Interventions: OTHER: Invisalign® SmileView™|OTHER: Invisalign aligners
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Intra-operative Rapid Identification of Lymph Node and Parathyroid
Status: UNKNOWN
Conditions: Thyroid Cancer|Parathyroid; Absent|Hypocalcemia|Hypoparathyroidism Postprocedural
Interventions: DIAGNOSTIC_TEST: Intraoperative identification method
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of FF-10101-01 in Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: AML, Adult
Interventions: DRUG: FF-10101-01
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of High Intensity Laser Therapy in the Management of Painful Calcaneal Spur
Status: COMPLETED
Conditions: Calcaneal Spur
Interventions: OTHER: HILT + exercise|OTHER: Placebo HILT + exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nutrition Beverage Tolerance Study
Status: COMPLETED
Conditions: Human Volunteers
Interventions: OTHER: Nutritional Beverage|OTHER: Nutritional Beverage|OTHER: Nutritional Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Light Emitting Diode Phototherapy on the Rate of Orthodontic Tooth Movement - A Clinical Study
Status: COMPLETED
Conditions: The Rate or Orthodontic Tooth Movement
Interventions: DEVICE: LED Phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Lipopolysaccharide (LPS) Study In Healthy Volunteers
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: PF-03715455|DRUG: PH-797804|DRUG: Placebo for PF-03715455|DRUG: Placebo for PH-797804
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Physical and Mental Load in the Surgeon Performing Laparoscopic Tasks
Status: UNKNOWN
Conditions: Stress
Interventions: DEVICE: Electrogram (EMG), heart rate variability (HRV), salivary cortisol, goniometry, inclinometry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Study Evaluating the Efficacy of Secukinumab 300mg in Chinese Adults With Active Ankylosing Spondylitis
Status: UNKNOWN
Conditions: Ankylosing Spondylitis (AS)
Interventions: DRUG: Secukinumab 300mg s.c.|DRUG: Secukinumab 150mg s.c.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Investigate the Efficacy and Safety of NW Low-Glu® in Patients With Type II Diabetes Mellitus
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DIETARY_SUPPLEMENT: NW Low-Glu®|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Self-Management Program for Older Adults With Multimorbidity
Status: COMPLETED
Conditions: Multimorbidity
Interventions: BEHAVIORAL: Self-Management Program for Older Adults with Multimorbidity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Mobile Application on the Pediatric Diabetes Management
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1|Child|Adolescent
Interventions: BEHAVIORAL: DİABOT (mobile application robot )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI)
Status: COMPLETED
Conditions: Cholecystolithiasis
Interventions: DEVICE: Dual-loop TCI|DEVICE: manual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Maxillary Sinus Floor Elevation Using DENSAH Burs Versus Summers Osteotomes
Status: UNKNOWN
Conditions: Implant Tissue Failure
Interventions: DEVICE: densah burs osseo densification drills|DEVICE: Summer's Osteotomes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characterization of Metabolomic Fingerprints in Patients With Acute Liver Failure and Acute-on-chronic Liver Failure With Hepatic Encephalopathy
Status: WITHDRAWN
Conditions: Hepatic Encephalopathy|Acute Liver Failure|Acute on Chronic Liver Failure
Interventions: OTHER: Blood collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Acceptability and Tolerability of Ketone Supplements and Effects of BHB Concentrations in Young Adults
Status: COMPLETED
Conditions: Exogenous Ketosis
Interventions: DIETARY_SUPPLEMENT: KE1 5g|DIETARY_SUPPLEMENT: KE1 10g|DIETARY_SUPPLEMENT: KE4 5g|DIETARY_SUPPLEMENT: KE 10g|OTHER: Placebo drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Electrical Stimulation as an Adjunctive Therapy to Increase Vascular Perfusion in People With PAD or PVD
Status: TERMINATED
Conditions: PAD - Peripheral Arterial Disease|PVD- Peripheral Vascular Disease
Interventions: DEVICE: Tennant Biomodulator-Pro™ Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CT-guided Radioactive Iodine-125 Seed Implantation for Recurrent Desmoid Tumors
Status: COMPLETED
Conditions: Brachytherapy|Desmoid Tumor|Radioactive Iodine-125 Seed Implantation
Interventions: RADIATION: CT-guided radioactive iodine-125 seed implantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Immunogenicity of a Single Dose of the Recombinant Live-Attenuated Respiratory Syncytial Virus (RSV) Vaccines RSV ΔNS2/Δ1313/I1314L, RSV 6120/ΔNS2/1030s, RSV 276 or Placebo, Delivered as Nose Drops to RSV-Seronegative Children 6 to 24 Months of Age
Status: COMPLETED
Conditions: Respiratory Syncytial Virus (RSV)
Interventions: BIOLOGICAL: RSV ΔNS2/Δ1313/I1314L Vaccine|BIOLOGICAL: RSV 6120/ΔNS2/1030s Vaccine|BIOLOGICAL: RSV 276 Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Accuracy of CFD-based RuiXin-FFR by Comparing With Pressure-wire-based FFR
Status: COMPLETED
Conditions: Coronary Artery Disease|Myocardial Ischemia|Myocardial Fractional Flow Reserve
Interventions: DIAGNOSTIC_TEST: Pressure wire fractional flow reserve|DIAGNOSTIC_TEST: CFD-based RuiXin-FFR
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MANUAL DIAPHRAGM RELEASE TECHNIQUE INCREASES TIDAL VOLUME IN ELDERLY
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Sham manual diaphragm release technique|OTHER: The manual diaphragm release technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: X-396(Ensartinib) Capsules in ALK-Positive NSCLC Patients With Brain Metastases
Status: UNKNOWN
Conditions: Nonsmall Cell Lung Cancer|Brain Metastases
Interventions: DRUG: X-396(Ensartinib) Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breast Cancer Locator Guided vs. Wire Localized Partial Mastectomy for Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer Female
Interventions: DEVICE: Breast Cancer Locator (BCL) guided partial mastectomy|DEVICE: Wire Localized (WL) partial mastectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of JS108 in Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Advanced Solid Tumors
Interventions: DRUG: JS108 (recombinant humanized anti-Trop2 mAb-Tub196 conjugate for injection)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Talking Pictures Social Media Intervention in Reducing Depressive Symptoms and Improving Spiritual Well-Being and Quality of Life in Adolescent and Young Adult Cancer Patients
Status: COMPLETED
Conditions: Malignant Neoplasm
Interventions: OTHER: Internet-Based Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Sea Buckthorn Oil on Mucous Membranes
Status: COMPLETED
Conditions: Mucous Membranes
Interventions: DIETARY_SUPPLEMENT: Sea buckthorn oil|DIETARY_SUPPLEMENT: Placebo oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: BCMA-CD19 cCAR T Cell Treatment of Relapsed/Refractory Systemic Lupus Erythematosus (SLE)
Status: RECRUITING
Conditions: Relapsed/Refractory, Systemic Lupus Erythematosus (SLE)
Interventions: BIOLOGICAL: BCMA-CD19 cCAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypofractionated Stereotactic Body Radiation & Fluorouracil or Capecitabine for Locally Advanced Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Adenocarcinoma|Recurrent Pancreatic Carcinoma|Stage I Pancreatic Cancer AJCC v6 and v7|Stage IA Pancreatic Cancer AJCC v6 and v7|Stage IB Pancreatic Cancer AJCC v6 and v7|Stage II Pancreatic Cancer AJCC v6 and v7|Stage IIA Pancreatic Cancer AJCC v6 and v7|Stage IIB Pancreatic Cancer AJCC v6 and v7|Stage III Pancreatic Cancer AJCC v6 and v7|Stage IV Pancreatic Cancer AJCC v6 and v7
Interventions: DRUG: Capecitabine|DRUG: Fluorouracil|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|RADIATION: Stereotactic Body Radiation Therapy|DRUG: Zoledronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sexual and Vaginal Health in Breast Cancer Women Receiving Aromatase Inhibitors Before and After CO2 Laser Therapy
Status: UNKNOWN
Conditions: Breast Cancer|Genitourinary Syndrome of Menopause
Interventions: DEVICE: CO2 LASER|DEVICE: CO2 SHAM LASER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: In Vivo Kinematics for Subjects Implanted With Klassic Total Knee Arthroplasty (TKA)
Status: COMPLETED
Conditions: Total Knee Arthroplasty|Osteo Arthritis Knee|Knee Implant|Knee Injuries
Interventions: DEVICE: Klassic Knee System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluate the Clinical Benefit of a Post-operative Treatment Associating Radiotherapy + Nivolumab + Ipilimumab Versus Radiotherapy + Capecitabine for Triple Negative Breast Cancer Patients With Residual Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Triple Negative Breast Neoplasms
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Heparin in Patients With Septic Shock
Status: WITHDRAWN
Conditions: Sepsis
Interventions: DRUG: heparin|DRUG: heparin|DRUG: heparin|DRUG: heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test How Well Different Doses of BI 771716 Are Tolerated by People With an Advanced Form of Age-related Macular Degeneration (AMD) Called Geographic Atrophy
Status: COMPLETED
Conditions: Geographic Atrophy
Interventions: DRUG: BI 771716
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ECigs, Inflammation and Oxidative Stress
Status: COMPLETED
Conditions: E-cigarettes, Oxidative Stress, Inflammation
Interventions: OTHER: e-cigarette|OTHER: empty (-cigarette sham control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Airtraq Versus Fiberoptic for Awake Tracheal Intubation
Status: COMPLETED
Conditions: Intubation;Difficult|Awake Intubation|Airway Complication of Anesthesia
Interventions: DEVICE: Videolaryngoscope Airtraq|DEVICE: Fiberoptic bronchoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Randomized Controlled Trial of a Patient Activation Tool in Pediatric Appendicitis (Antibiotics Alone vs. Appendectomy)
Status: COMPLETED
Conditions: Appendicitis|Children
Interventions: OTHER: Patient Activation Tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of the Combination of Empagliflozin and Linagliptin Compared to Linagliptin Alone Over 24 Weeks in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Linagliptin|DRUG: Empagliflozin + Linagliptin|DRUG: Empagliflozin + Linagliptin|DRUG: Empagliflozin + Linagliptin|DRUG: Empaglifozin placebo + Linagliptin placebo|DRUG: Empagliflozin + Linagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Usual Dose Rosuvastatin Plus Ezetimibe Versus High-dose Rosuvastatin on Coronary Atherosclerotic Plaque
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease
Interventions: DRUG: Rosuvastatin 10 mg plus ezetimibe 10 mg orally once a day|DRUG: Rosuvastatin 20 mg orally once a day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pathway Modulation by Raf, MEK, & Kinase Inhibitors
Status: COMPLETED
Conditions: Metastatic Cancer|Melanoma|Colon Cancer|Differentiated Thyroid Cancer|Hepatocellular Carcinoma|Renal Cell Carcinoma|Metastatic Melanoma|HCC|Metastatic Colon Cancer
Interventions: OTHER: Solar Simulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bacteremia and Procalcitonin Levels in Peroral Endoscopic Myotomy for Achalasia
Status: UNKNOWN
Conditions: Esophageal Achalasia
Interventions: DRUG: no antibiotic prophylaxis|DRUG: second-generation cephalosporin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Compensatory Training to Support Brain Healthy Lifestyle Changes in Those at Risk for Alzheimer's Disease
Status: COMPLETED
Conditions: Cognitive Symptom|Pre Senile Dementia|Alzheimer Disease
Interventions: BEHAVIORAL: Cognitive rehabilitation and health behavior change intervention|BEHAVIORAL: Self-implementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tac, Mini-MTX, MMF Versus Tac, MTX for GVHD Prevention
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Acute Biphenotypic Leukemia|Myelodysplastic Syndrome|Myeloproliferative Neoplasm|Non-Hodgkin Lymphoma|Hodgkins Disease|Chronic Lymphocytic Leukemia|Multiple Myeloma
Interventions: DRUG: tacrolimus|DRUG: methotrexate|DRUG: Mycophenolate mofetil|DRUG: Methotrexate (low dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pain Management Using Mobile Technology in Veterans With PTSD and TBI
Status: COMPLETED
Conditions: Chronic Pain|Posttraumatic Stress Disorders|Traumatic Brain Injury
Interventions: DEVICE: NeuroSky MindWave Mobile
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: The Effect of Macronutrients on Fibroblast Growth Factor 21 (FGF21) Secretion
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Sucrose|OTHER: Sucrose + protein|OTHER: Sucrose + fat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: ACT-DE for Diabetes Distress and HbA1c in Adults With Type 2 Diabetes
Status: RECRUITING
Conditions: Acceptance and Commitment Therapy|Diabetes Education|Diabetes Distress|HbA1c|Psychological Flexibility|Diabetes Self-management|Diabetes Management Self-efficacy
Interventions: BEHAVIORAL: ACT-DE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Flavopiridol and Irinotecan in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: alvocidib|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-polar RF and PEMF for Treatment of Vaginal Laxity and Mons Pubis and Labia for Improvement of Skin Laxity
Status: COMPLETED
Conditions: Vulvovaginal Atrophy|Menopause|Menopause Surgical
Interventions: DEVICE: Vulvovaginal treatment|DEVICE: Baseline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Atezolizumab With Neoadjuvant Chemotherapy for Patients With Newly-Diagnosed Advanced-Stage Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Ovarian Neoplasms
Interventions: DRUG: Atezolizumab|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Financial Incentives for Smoking Treatment II
Status: ENROLLING_BY_INVITATION
Conditions: Smoking Cessation|Tobacco Use Cessation
Interventions: BEHAVIORAL: Smoking cessation counseling (Quitline)|BEHAVIORAL: Smoking cessation pharmacotherapy (e.g, nicotine replacement therapy)|BEHAVIORAL: Financial incentives for smoking cessation|BEHAVIORAL: Financial incentives for use of evidence-based smoking cessation therapies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Longitudinal Follow-up of Brief Parenting Interventions to Reduce Risk of Child Physical Maltreatment
Status: COMPLETED
Conditions: Parenting|Child Behavior|Child Rearing
Interventions: OTHER: Triple P-Level 2|OTHER: Play Nicely|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Propranolol in Capillary Hemangiomas
Status: TERMINATED
Conditions: Hemangioma, Capillary
Interventions: DRUG: propranolol treatment|DRUG: placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II CT 2106 and 5-FU/FA in Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: CT-2106|DRUG: Folinic acid|DRUG: 5-FU (fluorouracil)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Safety, Tolerability and Pharmacodynamics of DWRX2003 Against COVID-19 (in Philippines)
Status: TERMINATED
Conditions: COVID-19 Patients
Interventions: DRUG: DWRX2003|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PTK787/ZK 222584 in Treating Patients With Unresectable Malignant Mesothelioma
Status: COMPLETED
Conditions: Malignant Mesothelioma
Interventions: DRUG: PTK787/ZK 222584
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adventure: Teacher Delivered Personality-targeted Interventions for Substance Misuse
Status: COMPLETED
Conditions: Alcohol Abuse|Drug Abuse|Depression|Panic Disorder|Conduct Disorder
Interventions: BEHAVIORAL: Personality-targeted interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessing Success of MTA and Pre-mixed Bioceramic in Mature Teeth With Irreversible Pulpitis With Full Pulpotomy.
Status: COMPLETED
Conditions: Pulpitis - Irreversible
Interventions: DRUG: Pro Root MTA®|DRUG: EBRRM®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study: Evaluation of Ulthera Versus Thermage for Treating the Face and Neck
Status: COMPLETED
Conditions: Skin Laxity|Wrinkles
Interventions: DEVICE: Ulthera System Treatment|DEVICE: Thermage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Oxabact (OC5) in Patients With Primary Hyperoxaluria
Status: COMPLETED
Conditions: Primary Hyperoxaluria
Interventions: BIOLOGICAL: Oxabact OC5 capsules|DRUG: Placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Hemodynamic Effects During Sustained Low-efficiency Dialysis Versus Continuous Veno-venous Hemofiltration for Patients With Intracranial Hypertension in a Cross Over Study
Status: WITHDRAWN
Conditions: End- Stage Renal Disease Patients
Interventions: PROCEDURE: hemodialysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Safety and Tolerability of E2730 After Multiple Dose and the Food Effect After Single Dose in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: E2730|DRUG: E2730-matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: RELOVAIR® Lung Deflation Study
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Fluticasone Furoate|DRUG: Vilanterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/IIa Study of Pharmacokinetics and Safety of Epidiferphane™ and Taxanes in Breast Cancer Patients
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: Epidiferphane|DRUG: Taxane Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Trigeminal Nerve Stimulation on Corneal Nerves and Chronic Ocular Pain
Status: COMPLETED
Conditions: Dry Eye|Neuropathic Pain|Eye Pain
Interventions: DEVICE: Trigeminal Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cognitive Rehabilitation During Transcranial Direct Current Stimulation
Status: COMPLETED
Conditions: Transcranial Direct Current Stimulation|Neurocognitive Disorders
Interventions: DEVICE: transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of UI-EWD vs. Conventional Endoscopic Therapy for Bleeding Ulcers
Status: RECRUITING
Conditions: Acute Gastrointestinal Bleeding
Interventions: DEVICE: UI-EWD|DEVICE: Conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Itacitinib in Advanced Hepatocellular Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Hepatocellular Carcinoma
Interventions: DRUG: Itacitinib (INCB039110)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof-of-Concept Study With BMS-817399 to Treat Moderate to Severe Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Placebo|DRUG: BMS-817399|DRUG: BMS-817399
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of an Experimental Radiopharmaceutical (131I-MIP-1095) in Men With Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Status: COMPLETED
Conditions: Prostate Cancer|Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Interventions: DRUG: 131I-MIP-1095
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Effect of Food on the Pharmacokinetics of a Single JNJ-39823277 (TPI-1062) Dose in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-39823277
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
Status: RECRUITING
Conditions: Heart Failure|Left Ventricular Systolic Dysfunction
Interventions: DRUG: Vericiguat tablet|DRUG: Vericiguat suspension|DRUG: Placebo tablet|DRUG: Placebo suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study for Evaluation of Efficacy and Safety of SH L 749 to Indolent B-cell Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma|Lymphoma, B-Cell|Lymphoma, Low-Grade
Interventions: DRUG: Zevalin (SH L 749 , BAY86-5128)|DRUG: Zevalin (SH L 749 , BAY86-5128)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Hiit Associated With Emotional Regulation on Negative Emotions
Status: UNKNOWN
Conditions: High Intensity Exercise|Cognitive Reassessment Strategy
Interventions: OTHER: HIIT and Cognitive Reassessment|OTHER: HIIT group|OTHER: Emotional regulation strategy group|OTHER: placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparative Trial of Micafungin Versus Fluconazole for Treating Esophageal Candidiasis
Status: COMPLETED
Conditions: Candidiasis, Oral
Interventions: DRUG: Micafungin|DRUG: Fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Accumbofrontal Tract Study in 2 Populations of Patients With Anorexia Nervosa and Obsessional Compulsive Disorder and Healthy Volunteer
Status: COMPLETED
Conditions: Accumbo Frontal Tract
Interventions: RADIATION: Multimodal MRI with diffusion sequence for anorexia nervosa patient|RADIATION: Multimodal MRI with diffusion sequence for obsessional compulsive disorder patient|RADIATION: Multimodal MRI with diffusion sequence for healthy volunteer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Looking for Personalized Nutrition for Obesity/Type 2 Diabetes Mellitus Prevention
Status: COMPLETED
Conditions: Overweight and Obesity|Diabetes Mellitus, Type 2|Metabolic Syndrome|Genetic Predisposition|Diet Modification
Interventions: OTHER: Normo-carbohydrate meal intake|OTHER: High-carbohydrate meal intake|OTHER: High-fat meal intake|OTHER: High-protein meal intake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Electroacupuncture (EA) Promotes Gastrointestinal Functional Recovery After Radical Colorectal Cancer Surgery
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer|Gastrointestinal Dysfunction
Interventions: DEVICE: Electroacupuncture group|OTHER: Sham EA group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zanubrutinib With Obinutuzumab in Untreated Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Zanubrutinib Oral Product|DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irinotecan and Carboplatin as Upfront Window Therapy in Treating Patients With Newly Diagnosed Intermediate-Risk or High-Risk Rhabdomyosarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Sarcoma
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: dexrazoxane hydrochloride|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: irinotecan hydrochloride|DRUG: vincristine sulfate|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Febrile Neutropenia by Synbiotics in Pediatric Cancer Patients
Status: UNKNOWN
Conditions: Febrile Neutropenia|Neutropenia|Infection in an Immunocompromised Host|Cancer
Interventions: DIETARY_SUPPLEMENT: Probio-Fix Inum|DIETARY_SUPPLEMENT: Beneo Synergy 1|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Stepped Approach to Reducing Risk of Suicide in Primary Care
Status: RECRUITING
Conditions: Suicidal Ideation|Suicide, Attempted|Suicide Prevention
Interventions: BEHAVIORAL: Stepped Approach to Reducing Risk of Suicide in Primary Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase II Safety and Tolerability Study With SEN0014196
Status: COMPLETED
Conditions: Huntington's Disease
Interventions: DRUG: SEN0014196|DRUG: SEN0014196|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Trial of Entecavir Versus Adefovir in the Treatment of Chronic Hepatitis B Infection
Status: COMPLETED
Conditions: Hepatitis B|Chronic Disease
Interventions: DRUG: entecavir|DRUG: adefovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Water and Coffee Intervention in Humans
Status: COMPLETED
Conditions: Excess Intake of Macronutrients|Excess Intake of Micronutrients|Vasopressin Low
Interventions: OTHER: Water|OTHER: Coffee|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Benefit and Safety of GSK2982772 in Moderate to Severe Psoriasis Participants
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: GSK2982772|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT