pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Clinical Study of PD-L1 Antibody ZKAB001（Drug Code） in Locally Advanced and Metastatic Urothelial Carcinoma
Status: UNKNOWN
Conditions: Urothelial Carcinoma
Interventions: DRUG: ZKAB001 5mg/kg|DRUG: ZKAB001 10mg/kg|DRUG: ZKAB001 15mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Use of Talimogene Laherparepvec and BRAF/MEK Inhibitor for Advanced Nodal BRAF Mutant Melanoma
Status: WITHDRAWN
Conditions: Melanoma (Skin)|Melanoma Stage IIIb-IVM1a|Metastasis Skin|Tumor Skin|BRAF Gene Mutation
Interventions: DRUG: Talimogene laherparepvec (T-Vec)|DRUG: Dabrafenib (BRAF Inhibitor)|DRUG: Trametinib (MEK Inhibitor)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imiquimod Treatment of High-grade CIN
Status: UNKNOWN
Conditions: Cervical Intraepithelial Neoplasia
Interventions: DRUG: Imiquimod|PROCEDURE: Large Loop Excision of the Transformation Zone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Two Different Type Blocks for Pain Relief in Totalabdominal Hysterectomy
Status: COMPLETED
Conditions: Ultrasonography
Interventions: DEVICE: PCA (patient controlled analgesia)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nivolumab and Ipilimumab in Mucinous Colorectal and Appendiceal Tumors
Status: TERMINATED
Conditions: Mucinous Adenocarcinoma of the Colon|Mucinous Adenocarcinoma of the Rectum
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Anesthetic Method on Cerebral Oxygen Saturation in Geriatric Patients Undergoing Transurethral Surgery
Status: COMPLETED
Conditions: Surgery
Interventions: DRUG: propofol, fentanyl, atracurium|DRUG: bupivacaine|DRUG: bupivacaine, Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Phase II Study of AVX/COVID-12 Vaccine in Subjects With Prior SARS-CoV-2 Immunity Evidence
Status: COMPLETED
Conditions: SARS CoV 2 Infection
Interventions: BIOLOGICAL: Recombinant NDV Vectored Vaccine for SARS-CoV-2|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Research Study in Children Born Small and Who Stayed Small. Treatment is Somapacitan Once a Week Compared to Norditropin® Once a Day
Status: ACTIVE_NOT_RECRUITING
Conditions: Short Stature Children Born Small for Gestational Age (SGA)
Interventions: DRUG: Somapacitan|DRUG: Norditropin®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of EGb761® on Brain Glucose Metabolism in Three Groups of Elderly Defined by Cognitive Functions
Status: COMPLETED
Conditions: Alzheimer's Disease|Cognitive Impairment
Interventions: DRUG: EGb761®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Baveno VI Criteria in Dynamic Monitoring of High-risk Varices in Compensated Cirrhotic Patients
Status: UNKNOWN
Conditions: Cirrhosis|Varices|Non-invasive Evaluation
Interventions: DIAGNOSTIC_TEST: Complete blood count|DIAGNOSTIC_TEST: Transient elastrography|DIAGNOSTIC_TEST: Endoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Collection of Human Biological Samples for the Development and Validation of New Methods of Diagnosis and for the Realization of Expertises Diagnostics in the Field of Infectious Diseases and Tropical
Status: COMPLETED
Conditions: Infectious Disease|Tropical Disease
Interventions: BIOLOGICAL: biological samples|PROCEDURE: lumbar puncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase III Study Assessing the Safety and Efficacy of DE-117 Ophthalmic Solution Compared With Latanoprost Ophthalmic Solution in Subjects With OAG or OHT
Status: COMPLETED
Conditions: Open Angle Glaucoma or Ocular Hypertension
Interventions: DRUG: DE-117|DRUG: Latanoprost ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of the SpiderMass for in Vivo Analysis of the Skin in Five Chronic Inflammatory Dermatosis
Status: COMPLETED
Conditions: Acne|Atopic Dermatitis|Psoriasis Vulgaris|Rosacea|Seborrheic Dermatitis|Healthy
Interventions: OTHER: in-vivo mesure|OTHER: Scotch|OTHER: Lipid index|OTHER: Absorbant paper|OTHER: Hydratation Index|OTHER: TransEpidermal Water Loss
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Efficacy and the Mechanism of Chinese Herbal Formula SS-1 for Sjögren's Syndrome
Status: UNKNOWN
Conditions: Sjögren's Syndrome
Interventions: DRUG: SS-1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combining Performance of Call EMS and Simultaneous Chest Compressions in a Lone Rescuer CPR
Status: COMPLETED
Conditions: Out-of-Hospital Cardiac Arrest
Interventions: BEHAVIORAL: Combi lone-CPR|BEHAVIORAL: Conventional lone-CPR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Childhood Obesity Treatment: A Maintenance Approach
Status: COMPLETED
Conditions: Childhood Overweight|Childhood Obesity
Interventions: BEHAVIORAL: SFM+ Low Dose|BEHAVIORAL: Weight Maintenance Education|BEHAVIORAL: SFM+ High Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Possible Role of Roflumilast in Diabetic Nephropathy
Status: UNKNOWN
Conditions: Diabetic Nephropathies
Interventions: DRUG: Roflumilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Abuse Potential of Intranasal VYCAVERT Tablets (Hydrocodone Bitartrate/Acetaminophen) in Recreational Opioid Users
Status: COMPLETED
Conditions: Opioid-Related Disorders
Interventions: DRUG: Placebo taken first|DRUG: Generic H/A taken first|DRUG: Vycavert taken first|DRUG: Generic H/A plus i taken first|DRUG: Generic H/A plus p taken first
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Olanzapine Versus Placebo for Prevention of Postoperative Delirium After Joint Replacement Surgery
Status: COMPLETED
Conditions: Delirium
Interventions: DRUG: olanzapine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Ultrasound Combine TENS in Treatment of Upper Trapezius Myofascial Pain
Status: COMPLETED
Conditions: Myofascial Pain Syndromes
Interventions: DEVICE: Therapeutic ultrasound combine TENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NovoLog Observation Trial in Subjects With Type 1 and Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: GnRH Therapy on Cognition in Down Syndrome
Status: RECRUITING
Conditions: Down Syndrome|Cognitive Decline|Alzheimer Disease, Early Onset|Olfaction Disorders
Interventions: DRUG: GnRH, gonadorelin acetate|DRUG: 0.9% NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Topiramate 25 mg Capsule Mixed With Applesauce Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Topiramate 25 mg Capsules|DRUG: Topamax® 25 mg Capsules|OTHER: Applesauce
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Root Caries Excavation With Air Water/Powder Prophylaxis Device for ART Restorations
Status: UNKNOWN
Conditions: Dental Caries Extending Into Dentin|Root Caries
Interventions: PROCEDURE: Control: Hand instrumentation for caries excavation|PROCEDURE: Intervention 1: EMS Airflow device for caries excavation|PROCEDURE: Intervention 2: Hand excavation + EMS Airflow device for caries excavation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treat to Target Trial in Axial Spondylo Arthritis : The TICOSPA (Tight Control in Spondyloarthritis)
Status: COMPLETED
Conditions: Axial Spondyloarthritis
Interventions: OTHER: Follow-up every 3 months during 1 year (data collection in eCRF)|OTHER: Follow-up every month to follow the pre-defined strategy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: X-Change HF - Exchange of the Existing Pacemaker/ICD in Bradycardia Patients Suffering From Heart Failure
Status: TERMINATED
Conditions: Heart Failure, Congestive
Interventions: DEVICE: CRT-P or CRT-D Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Exploring Heart Rate Variability, EEG Pattern, and Corticomuscular Coherence After Cervical Sagittal Alignment Restoration
Status: NOT_YET_RECRUITING
Conditions: Cervical Lordosis
Interventions: DEVICE: Denneroll cervical traction orthodontic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Bone Marrow Mesenchymal Stem Cell in Pulmonary Hemosiderosis
Status: UNKNOWN
Conditions: Idiopathic Pulmonary Hemosiderosis
Interventions: BIOLOGICAL: Bone marrow mesenchymal stem cells in treatment of Idiopathic pulmonary hemosiderosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Efficacy of the Extracorporeal Liver Assist Device (ELAD) System in Patients With Hepatic Insufficiency
Status: COMPLETED
Conditions: Acute Hepatitis|Chronic Hepatitis
Interventions: BIOLOGICAL: ELAD plus standard of care treatment|OTHER: Standard of care treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cryoanalgesia and Post-thoracotomy Pain in Minimally Invasive Cardiothoracic Surgery
Status: NOT_YET_RECRUITING
Conditions: Cryotherapy Effect|Post Operative Pain
Interventions: DEVICE: Atricure Inc. Nitrous oxide Cryoprobe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Women's Isoflavone Soy Health (WISH) Trial
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DIETARY_SUPPLEMENT: 25 gm soy protein supplement|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas
Status: COMPLETED
Conditions: Childhood Alveolar Soft-part Sarcoma|Childhood Angiosarcoma|Childhood Desmoplastic Small Round Cell Tumor|Childhood Epithelioid Sarcoma|Childhood Fibrosarcoma|Childhood Leiomyosarcoma|Childhood Liposarcoma|Childhood Malignant Mesenchymoma|Childhood Neurofibrosarcoma|Childhood Synovial Sarcoma|Chordoma|Desmoid Tumor|Metastatic Childhood Soft Tissue Sarcoma|Nonmetastatic Childhood Soft Tissue Sarcoma|Recurrent Childhood Soft Tissue Sarcoma
Interventions: OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fruquintinib Combined With Sintilimab and Chemotherapy in the Treatment of Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Fruquintinib，Sintilimab，Pemetrexed，Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Buspirone in Reducing Shortness of Breath in Patients With Cancer
Status: COMPLETED
Conditions: Dyspnea|Pulmonary Complications|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: buspirone hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 2 Study of Oral MKC-1 in Patients With Unresectable or Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: MKC-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nab-paclitaxel/Rituximab-coated Nanoparticle AR160 in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma, LS1681 Trial
Status: COMPLETED
Conditions: Recurrent Aggressive Non-Hodgkin Lymphoma|Recurrent B-Cell Non-Hodgkin Lymphoma|Recurrent Small Lymphocytic Lymphoma|Refractory Aggressive Non-Hodgkin Lymphoma|Refractory B-Cell Non-Hodgkin Lymphoma|Refractory Small Lymphocytic Lymphoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Nab-paclitaxel/Rituximab-coated Nanoparticle AR160|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Imaging Study With 89Zr-Trastuzumab in HER2-positive Metastatic Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Neoplasms|Secondary|HER2 Positive Carcinoma of Breast
Interventions: DRUG: Zr89-trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Isatuximab, Lenalidomide, Bortezomib, and Dexamethasone in NDMM
Status: RECRUITING
Conditions: Multiple Myeloma|Newly Diagnosed Multiple Myeloma (NDMM)|Autologous Stem Cell Transplant
Interventions: DRUG: Isatuximab|DRUG: Lenalidomide|DRUG: Bortezomib Injection|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aligning Patients and Their Primary Care Providers
Status: COMPLETED
Conditions: Primary Health Care|Quality of Health Care|Comorbidity|Communication|Medical Informatics Applications
Interventions: BEHAVIORAL: Visit Planner|OTHER: Attention Control Pamphlet|DEVICE: iPad
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Dexmedetomidine Versus Morphine and Midazolam in Prevention and Treatment of Delirium After Adult Cardiac Surgery
Status: COMPLETED
Conditions: Delirium
Interventions: DRUG: Dexmedetomidine Hydrochloride|DRUG: Morphine and Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Benzodiazepine-free Anesthetic for Reduction of Delirium (B-Free)
Status: COMPLETED
Conditions: Post-operative Delirium
Interventions: DRUG: Benzodiazepine - limited use strategy|DRUG: Benzodiazepine - Ad libitum strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of High-dose Rosuvastatin Versus Low-dose Rosuvastatin Plus Ezetimibe on Carotid Plaque Inflammation in Patients With Acute Coronary Syndrome
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Carotid Atherosclerotic Plaque With Inflammation
Interventions: DRUG: high-dose rosuvastatin|DRUG: low-dose rosuvastatin plus ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemoimmunotherapy Combined With Hyperthermia and Spatially-Fractionated Radiotherapy in Advanced Biliary Tract Cancer
Status: NOT_YET_RECRUITING
Conditions: Biliary Tract Cancer
Interventions: DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Durvalumab|RADIATION: Spatially Fractionated RT|DEVICE: Deep Hyperthermia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lactobacillus Reuteri Versus Herbal Drop in the Treatment of Infantile Colic: a Prospective Study
Status: COMPLETED
Conditions: Crying
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri|DIETARY_SUPPLEMENT: Herbal drop|DIETARY_SUPPLEMENT: placebo sterile water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Irish Omega-3 Study
Status: UNKNOWN
Conditions: Psychotic Disorders
Interventions: DIETARY_SUPPLEMENT: 1000mg of eicosapentaenoic acid and 1000mg docosahexaenoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study of Safety and Efficacy of Ligelizumab in the Treatment of CSU in Adolescents and Adults Inadequately Controlled With H1-antihistamines
Status: COMPLETED
Conditions: Chronic Spontaneous Urticaria
Interventions: BIOLOGICAL: Ligelizumab|BIOLOGICAL: Omalizumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Transition From Blastomere to Trophectoderm Biopsy: Comparing Two PGS Strategies
Status: COMPLETED
Conditions: Infertility|Preimplantation Genetic Screening
Interventions: PROCEDURE: Cleavage stage biopsy group|PROCEDURE: Trophectoderm biopsy group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vitamin C and Septic Shock
Status: COMPLETED
Conditions: Septic Shock|Sepsis
Interventions: DRUG: Vitamin C|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial in Stable Intermediate Coronary Lesions and Grey-zone FFR Values
Status: COMPLETED
Conditions: Grey-zone Fractional Flow Reserve|Intermediate Coronary Lesions|Stable Angina|Coronary Physiology
Interventions: PROCEDURE: PCI|DRUG: Optimal Medical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multilevel Approach to Increasing HPV Vaccine Initiation Among Adolescents - Part 3
Status: COMPLETED
Conditions: Human Papilloma Virus
Interventions: OTHER: postcard campaign|OTHER: Health Information Technology system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Multi Center, Study to Evaluate the Safety and Efficacy of the VasQ External Support Device for Arteriovenous Fistulas
Status: COMPLETED
Conditions: Vascular Access|End Stage Renal Disease
Interventions: DEVICE: VasQ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Undisplaced Femoral Neck Fractures in the Elderly: A Trial Comparing Internal Fixation to Hemiarthroplasty
Status: UNKNOWN
Conditions: Femoral Neck Fractures
Interventions: DEVICE: Hemi - arthroplasty|DEVICE: internal fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DDI Study to Investigate Interaction Between Amikacin and POL7080
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: POL7080|DRUG: Amikacin|DRUG: POL7080 + Amikacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Tomato Sauce on Endothelial Dysfunction Induced by a High Fat Meal in Healthy Subjects
Status: COMPLETED
Conditions: Endothelial Dysfunction
Interventions: DIETARY_SUPPLEMENT: tomato sauce
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sepsis Pre-Alert Monitoring Intervention: Study to Investigate Targeted Enhanced Monitoring for Sepsis
Status: NOT_YET_RECRUITING
Conditions: Sepsis
Interventions: OTHER: Vital Signs at 2 Hours|OTHER: Confusion Assessment method for the ICU (CAM-ICU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Brief Title: Study of Efficacy and Safety of Canakinumab as Adjuvant Therapy in Adult Subjects With Stages AJCC/UICC v. 8 II-IIIA and IIIB (T>5cm N2) Completely Resected Non-small Cell Lung Cancer Acronym: CANOPY-A
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Canakinumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of MOX/ALB Co-administration
Status: COMPLETED
Conditions: Trichuriasis|Ascariasis|Hookworm Infections
Interventions: DRUG: Moxidectin 2 mg Oral Tablet|DRUG: Albendazole 400 mg Oral Tablet|DRUG: Ivermectin 3 mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Difference in Occurrence of Rebound Pain in Patients Undergoing Surgery Under Popliteal Block or Ankle Block
Status: NOT_YET_RECRUITING
Conditions: Anesthesia, Regional|Anesthesia and Analgesia
Interventions: OTHER: Forefoot bone surgery|OTHER: Forefoot bone surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase I Trial of Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Cisplatin Plus Early Postoperative Intraperitoneal Paclitaxel and 5-FU for Peritoneal Carcinomatosis
Status: COMPLETED
Conditions: Carcinoma|Peritoneal Neoplasm
Interventions: DRUG: Cisplatin|DRUG: Paclitaxel|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of LY3537021 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3537021|DRUG: Liraglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Postoperative Anelgesic Effect of Rhomboid Intercostal Nerve Block Versus Erector Spinae Plane Block
Status: ENROLLING_BY_INVITATION
Conditions: Post Operative Pain
Interventions: DRUG: Rhomboid intercostal plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomized, Open, Prospective Clinical Research of Fluorouracil Implant to Improve Surgical Gallbladder Cancer and Bile Duct Cancer
Status: UNKNOWN
Conditions: Gallbladder Cancer|Bile Duct Cancer
Interventions: DRUG: Fluorouracil implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Precision Medicine in Action: Phase II Trial of Response Adaptive Ablative Pre-operative SPBI (RAPS) and Non-operative Sentinel Lymph Node Biopsy in Patients With Early-stage ER+ Breast Cancer: RAPS Trial
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: RADIATION: Radiomics on MRI|DRUG: microbubble CEUS Contrast Enhanced Ultrasound (CEUS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Atezolizumab in Combination With Cabozantinib Compared to Cabozantinib Alone in Participants With Advanced Renal Cell Carcinoma After Immune Checkpoint Inhibitor Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Atezolizumab|DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Mesh Infections in Open Hernia Repairs
Status: UNKNOWN
Conditions: Patients Undergoing Open Hernia Repair|Patients Undergoing Ventral or Inguinal Hernia Repair
Interventions: PROCEDURE: vancomycin-soaked mesh|PROCEDURE: plain mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: A Nutrient Cocktail to Protect Against Physical Inactivity
Status: COMPLETED
Conditions: Metabolic Disturbance|Glucose Intolerance|Physical Inactivity|Glucose Metabolism Disorders|Lipid Metabolism Disorders|Oxidative Stress
Interventions: DIETARY_SUPPLEMENT: XXS-2A + Omega-3 + Vitamin E + Selenium|DIETARY_SUPPLEMENT: control diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Botswana TDF/FTC Oral HIV Prophylaxis Trial
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Tenofovir Disoproxil Fumarate 300 mg + Emtricitabine 200 mg|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A 6-months Evaluation of Patients' Compliance and Oral Hygiene During Rapid Maxillary Expander (RME) Treatment Using "Ortodontika" Smartphone Application
Status: ACTIVE_NOT_RECRUITING
Conditions: Maxillary Transverse Deficiency
Interventions: DEVICE: Ortodontika app|OTHER: Verbal instructions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dexmedetomidine Infusion and Surgical Pleth Index In Pediatrics
Status: COMPLETED
Conditions: Pain|Hypospadias
Interventions: DRUG: Dexmedetomidine|DRUG: Lactated Ringer|PROCEDURE: Hypospadias|DEVICE: Surgical pleth index
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trifecta™ GT Post Market Clinical Follow-up
Status: COMPLETED
Conditions: Aortic Valve Disease|Aortic Valve Disorder
Interventions: DEVICE: Trifecta GT (Glide Technology) Valve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Feasibility and Preliminary Efficacy of the Mindful-Healthy Family Intervention With Rural Families
Status: ACTIVE_NOT_RECRUITING
Conditions: Overweight and Obesity
Interventions: BEHAVIORAL: MM-based MI|OTHER: healthy education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of Vintafolide (MK-8109, EC145) for the Treatment of Recurrent or Refractory Solid Tumors (MK-8109-006, EC-FV-01)
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Vintafolide IV Bolus|DRUG: Vintafolide IV Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Randomized Open-Label PK Study of LY03004 Compared to Risperdal® Consta® in Stable Patients With Schizophrenia or Schizoaffective Disorder
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Risperdal® Consta®|DRUG: LY03004
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adherence to Vaginal Estrogen Therapy in Hypoestrogenic Women With Recurrent Urinary Tract Infections
Status: RECRUITING
Conditions: Recurrent Urinary Tract Infection|Hypoestrogenism
Interventions: DRUG: Estring Vaginal Product|DRUG: Vagifem|DRUG: Estrace 0.01% Vaginal Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Persona Ti-Nidium Post-Market Clinical Follow-up
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee Pain Chronic|Osteoarthritis|Rheumatoid Arthritis|Traumatic Arthritis|Polyarthritis|Varus Deformity|Valgus Deformity|Flexion Deformity of the Knee|Avascular Necrosis|Patellofemoral Osteoarthritis
Interventions: DEVICE: Zimmer Biomet Persona Ti-Nidium Total Knee System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ZEN003694 and Talazoparib in Patients With Triple Negative Breast Cancer
Status: TERMINATED
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: ZEN003694|DRUG: Talazoparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ferric Carboxymaltose in Type 2 Diabetes Mellitus (T2DM) Patients With Iron Deficiency
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Iron Deficiency
Interventions: DRUG: ferric carboxymaltose|DRUG: NaCl (0,9%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Geriatric Lateral Compression 1 Pelvic Fractures
Status: RECRUITING
Conditions: Lateral Compression 1 Pelvic Fracture
Interventions: PROCEDURE: Percutaneous screw fixation|OTHER: Pain management and physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacies of Different Agents in Molar-Incisor Hypomineralization
Status: NOT_YET_RECRUITING
Conditions: Molar-Incisor Hypomineralization
Interventions: OTHER: GC Fuji Triage ® GC America Inc., Alsip, Illinois )|OTHER: BeutiSealant (Shofu, Kyoto, Japonya)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study of FOR-6219 in Capsule and Tablet Formulations
Status: COMPLETED
Conditions: Relative Bioavailability
Interventions: DRUG: FOR-6219 capsule formulation|DRUG: FOR-6219 tablet formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Oral Rapamycin Plus Bare Metal Stents vs Drug Eltuting Stents
Status: COMPLETED
Conditions: Coronary Heart Disease|Coronary Restenosis
Interventions: DRUG: Oral sirolimus|DEVICE: Drug Eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Low-volume Aerobic Interval Training in Overweight Individuals at Increased Cardiometabolic Risk
Status: COMPLETED
Conditions: Overweight and Obesity|Metabolic Syndrome
Interventions: OTHER: Control|OTHER: HIIT|OTHER: MIIT-HR|OTHER: MIIT-LT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Efficacy and Safety of Insuman Comb 25 Versus Novolin® 30R Twice Daily Over 24 Weeks in Type 2 Diabetes Patients With Insulin Therapy
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Insulin human/Insuman Comb 25 (HR1799)|DRUG: Insulin human/Novolin® 30R
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robot Assisted Supraomohyoid Neck Dissection Via Retroauricular Approach
Status: UNKNOWN
Conditions: Head and Neck Neoplasms
Interventions: PROCEDURE: robot assisted neck dissection via retroauricular approach|PROCEDURE: Conventional neck dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tadalafil and Acetazolamide Versus Acetazolamide in Acute Mountain Sickness Prevention
Status: COMPLETED
Conditions: Pulmonary Edema|Cerebral Edema
Interventions: DRUG: Tadalafil and acetazolamide|DRUG: Acetazolamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety of Sitafloxacin in Adult Subjects With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Status: RECRUITING
Conditions: COPD Exacerbation Acute
Interventions: DRUG: Sitafloxacin|DRUG: Moxifloxacin Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction Chemotherapy Followed by CCRT According to EGFR Mutation Status in NSCLC III
Status: UNKNOWN
Conditions: Lung Cancer|NSCLC
Interventions: DRUG: Erlotinib|DRUG: Induction or consolidation IP chemotherapy|DRUG: CCRT with IP chemotherapy (Irinotecan + Cisplatin)|RADIATION: CCRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Doppler Flow From the Femoral Artery as a Reflection of Cardiac Flow in a Vascular Fluid Test
Status: UNKNOWN
Conditions: Acute Circulatory Failure
Interventions: PROCEDURE: Doppler measurement of blood flow in the outflow tract of the left ventricle and the femoral artery,Reading blood pressures displayed on the monitor.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Programmed Allogeneic CRISPR-edited T Cells Engineered to Express Anti-CD19 Chimeric Antigen Receptor (PACE CART19) in Patients With Relapsed Or Refractory CD19+ Leukemia and Lymphoma
Status: WITHDRAWN
Conditions: Acute Lymphoblastic Leukemia|Chronic Lymphocytic Leukemia|Non Hodgkin Lymphoma
Interventions: BIOLOGICAL: PACE CART19
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Determine Optimal Phase II Dose of the Oral Dual CAIX Inhibitor/ Radiosensitizer
Status: WITHDRAWN
Conditions: Solid Tumors|Head and Neck Neoplasms
Interventions: DRUG: DTP348
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Part 2 of Phase 1 Study of GC1008 to Treat Advanced Melanoma (Part 2 Will Only Accept and Treat Patients With Advanced Malignant Melanoma)
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Anti-Transforming Growth Factor-beta (GC 1008)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Therapeutic Autologous Lymphocytes, Aldesleukin, and Denileukin Diftitox in Treating Patients With Stage III-IV Melanoma
Status: TERMINATED
Conditions: Recurrent Melanoma|Stage III Melanoma|Stage IV Melanoma
Interventions: BIOLOGICAL: therapeutic autologous lymphocytes|BIOLOGICAL: aldesleukin|BIOLOGICAL: denileukin diftitox|PROCEDURE: biopsy|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|GENETIC: polymerase chain reaction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Sexual Function Study for BPH Subjects
Status: COMPLETED
Conditions: Prostatic Hyperplasia
Interventions: DRUG: Dutasteride plus tamsulosin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Total Genotype Score, Growth, Maturation and Loading Exposure as Risk Factors for Injury in Elite Male Youth Football
Status: COMPLETED
Conditions: Fractures in Children|Apophysitis|Muscle Strain|Ligament Injury|Tendon Injuries|Genetic Predisposition
Interventions: GENETIC: Total Genotype Risk Score
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of GDC-0853 in Participants With Refractory Chronic Spontaneous Urticaria (CSU).
Status: COMPLETED
Conditions: Urticaria
Interventions: DRUG: GDC-0853|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Voretigene Neparvovec in Japanese Patients With Biallelic RPE65 Mutation-associated Retinal Dystrophy
Status: ACTIVE_NOT_RECRUITING
Conditions: Biallelic RPE65 Mutation-associated Retinal Dystrophy
Interventions: GENETIC: voretigene neparvovec
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HOST - DAPT Duration According the Bleeding Risk
Status: RECRUITING
Conditions: Coronary Artery Disease|Acute Myocardial Infarction|Stable Angina
Interventions: DRUG: Dual antiplatelet agent duration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Warfarin Initiation in Mechanical Mitral Valve Replacement Patients
Status: COMPLETED
Conditions: Mitral Valve Disease
Interventions: DRUG: Warfarin Sodium 5 MG|DRUG: Warfarin Sodium 3 MG|DRUG: Enoxaparin Sodium 100 MG/ML Prefilled Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Nutritional Supplement to Support People With Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DIETARY_SUPPLEMENT: Nutritional supplement|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of CT-868 in Type 1 Diabetes Mellitus
Status: RECRUITING
Conditions: Overweight|Obese|Type 1 Diabetes Mellitus
Interventions: DRUG: CT-868|DEVICE: CT-868 Pen Injector|DRUG: : CT-868 Pen Injector, Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Heterozygous Familial Hypercholesterolemia (MK-0616-017) CORALreef HeFH
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypercholesterolemia|Familial Hypercholesterolemia
Interventions: DRUG: Enlicitide Decanoate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of BGS649 in Male Obese Subjects With Hypogonadotropic Hypogonadism
Status: COMPLETED
Conditions: Hypogonadotropic Hypogonadism
Interventions: DRUG: BGS649|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Compare the Effect of Receiving the Technology-based Training Along With the Conventional Therapy to the Conventional Therapy Alone on Executive Functions Among People With Traumatic Brain Injury With Mild to Moderate Cognitive Deficit
Status: RECRUITING
Conditions: Traumatic Brain Injury
Interventions: DEVICE: technology based intervention along with conventional therapy|OTHER: conventional therapy alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Onartuzumab in Combination With mFOLFOX6 in Participants With Metastatic HER2-Negative and MET-Positive Gastroesophageal Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: 5-Fluoruracil|DRUG: Folinic acid|DRUG: Onartuzumab|DRUG: Oxaliplatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Pharmacokinetics of MEDI0382 in Overweight/Obese Subjects of Japanese or Chinese Descent
Status: COMPLETED
Conditions: Safety|Healthy Subjects
Interventions: DRUG: MEDI0382|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Characteristics of Immunity in Gut Mucosa, Spinal Fluid, Lymph Node and Blood of HIV Negative Thais and Thais With HIV Infection
Status: RECRUITING
Conditions: HIV-infection
Interventions: PROCEDURE: Colon biopsy, lymph node biopsy, lumbar puncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Gait Modification for Knee Osteoarthritis
Status: TERMINATED
Conditions: Osteoarthritis, Knee
Interventions: BEHAVIORAL: Specific Modification Target|BEHAVIORAL: Self-directed Modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PSV on Ventilation Inhomogeneity and Lung Function in Patients Under SB Across LMA
Status: COMPLETED
Conditions: Respiratory Function Tests|Anesthesia, General|Patient Positioning|Ventilation
Interventions: PROCEDURE: general anesthesia across LMA|PROCEDURE: Spontaneous breathing(SB)|PROCEDURE: Pressure Support Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effectiveness of GentleWave on the Healing of Apical Periodontitis: A Prospective Cohort Study
Status: ENROLLING_BY_INVITATION
Conditions: Apical Periodontitis
Interventions: DEVICE: GentleWave System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Safety and Effectiveness of Ustekinumab (CNTO 1275) in Patients With Moderate to Severe Plaque-type Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: ustekinumab|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics (PK) and Pharmacodynamics (PD) Study of Single and Multiple Ascending Doses of JNJ-41443532 in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-41443532|DRUG: JNJ-41443532|DRUG: JNJ-41443532|DRUG: JNJ-41443532|DRUG: JNJ-41443532|DRUG: Placebo|DRUG: JNJ-41443532
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Adherence to HIV Treatment Postpartum: The Implications of Transitions Among Women Living With HIV in South Africa
Status: COMPLETED
Conditions: HIV|Pregnancy Related
Interventions: BEHAVIORAL: Transition Theory-based Intervention|BEHAVIORAL: Enhanced Standard of Care Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of IV Ravulizumab in Patients With COVID-19 Severe Pneumonia
Status: TERMINATED
Conditions: COVID-19 Severe Pneumonia|Acute Lung Injury|Acute Respiratory Distress Syndrome|Pneumonia, Viral
Interventions: BIOLOGICAL: Ravulizumab|OTHER: BSC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a Nipah Virus Vaccine
Status: COMPLETED
Conditions: Nipah Virus Infection
Interventions: BIOLOGICAL: HeV-sG-V|BIOLOGICAL: Normal Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Faecal Bacteriotherapy for Postantibiotic Diarrhoea in Critically Ill Patients
Status: RECRUITING
Conditions: Diarrhea Caused by Drug|Clostridium Difficile Infections
Interventions: OTHER: Faecal bacteriotherapy (FBT)|OTHER: standard-of-care protocolised treatment of postantibiotic diarhea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China
Status: RECRUITING
Conditions: Essential Hypertension|Liver Cancer|Nasopharyngeal Cancer|Pancreatic Cancer|Lung Cancer|Chronic Kidney Diseases|Acute Coronary Syndrome|Epilepsy|Gastric Cancer|Primary Aldosteronism|Subclinical hypothyroïdism
Interventions: OTHER: no intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p