pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Rebamipide (Regular & Nanoparticulated) vs. Clobetasol in Management of Methotrexate-Induced Oral Ulceration in Rheumatoid Arthritis Patients
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Rebamipide|DRUG: Nanoparticulated Rebamipide|DRUG: Clobetasol Propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is the Vaginal Microbiome and Metabolome Associated With Spontaneous Preterm Birth (sPTB) in Multiple Pregnancies?
Status: RECRUITING
Conditions: Preterm Birth|Preterm Labor|Multiple; Pregnancy, Complicated|Twin Dichorionic Diamniotic Placenta|Twin Monochorionic Monoamniotic Placenta|Twin; Pregnancy, Affecting Fetus or Newborn|Vaginal Microbiome|Cervical Stiffness
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ideal Anatomic Location for Saphenous Nerve Blocks: A Prospective Clinical Evaluation
Status: COMPLETED
Conditions: Foot Injury|Ankle Injury
Interventions: PROCEDURE: Saphenous Nerve Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Etomidate Emulsion for Sedation in Patients Scheduled for Upper Gastrointestinal (GI) Endoscopy
Status: COMPLETED
Conditions: Complication of Gastrostomy
Interventions: DRUG: Etomidate|DRUG: Fentanyl|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of NVA237 in Patients With Poorly Controlled Asthma
Status: WITHDRAWN
Conditions: Asthma
Interventions: DRUG: NVA237|DRUG: Placebo to NVA237|DRUG: salbutamol/ albuterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Femoral Preincisional Block in Acute Postoperative Pain Management of Surgery Orthopaedic Lower Limb
Status: COMPLETED
Conditions: Surgery
Interventions: PROCEDURE: Femoral block by ultrasound and neurostimulation|DRUG: Intravenous analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RRx-001 in Combination With Irinotecan in Metastatic or Advanced Cancer (PAYLOAD)
Status: TERMINATED
Conditions: Malignant Solid Tumor|Metastatic Cancer|Advanced Cancer
Interventions: DRUG: RRx-001|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Development and Piloting of 'Power Up': A Tool for Young People With Internalising/Emotional Disorders to Make Shared Decisions in Child and Adolescent Mental Health Services (CAMHS)
Status: UNKNOWN
Conditions: Internalising Disorders|Anxiety|Depression
Interventions: BEHAVIORAL: Shared Decision Making tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gemcitabine Hydrochloride and Docetaxel With or Without Bevacizumab in Treating Patients With Advanced or Recurrent Uterine Leiomyosarcoma
Status: TERMINATED
Conditions: Recurrent Uterine Corpus Sarcoma|Stage IIIA Uterine Sarcoma|Stage IIIB Uterine Sarcoma|Stage IIIC Uterine Sarcoma|Stage IVA Uterine Sarcoma|Stage IVB Uterine Sarcoma|Uterine Corpus Leiomyosarcoma
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Docetaxel|BIOLOGICAL: Filgrastim|DRUG: Gemcitabine Hydrochloride|BIOLOGICAL: Pegfilgrastim|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AK112 Combined With Chemotherapy as the First-line Treatment in Advanced Esophageal Squamous Cell Carcinoma Patients
Status: NOT_YET_RECRUITING
Conditions: ESCC|Advanced Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Ivonescimab combined with albumin paclitaxel and cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Three-dimensional Versus Two-dimensional Ultrasound Guided Embryo Transfer in Women Undergoing ART Treatment
Status: COMPLETED
Conditions: Infertility
Interventions: DEVICE: Two-dimensional ultrasound|DEVICE: Three-dimensional ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Deep Brain Stimulation (DBS) of the Right Operculum 3 (OP3) in Permanent Non-pulsatile Disabling Tinnitus (TINNOP3-DBS)
Status: RECRUITING
Conditions: Severe Permanent Uni or Bilateral Non-pulsatile Tinnitus|Without Associated Vestibular Pathology|Resistant to Therapeutic Failure|With or Without Hearing Loss
Interventions: DEVICE: DBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Functional Electrical Stimulation Cycling Ergometry in Addition to Robotic Rehabilitation
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injuries
Interventions: OTHER: Robotic rehabilitation combined with Functional Electrical Stimulation (FES) bicycle ergometry group|OTHER: Robotic rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Traumatic Events in Childhood, Attachment, Pain Perception, Epigenetic Marks, Quality of Life and Resilience.
Status: RECRUITING
Conditions: Chronic Pain|Adverse Childhood Experiences|Attachment Styles|Chronic Stress|Resilience, Psychological|Quality of Life|Epigenesis, Genetic
Interventions: GENETIC: Biological samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fascia Iliaca Compartment Block For Analgesia After Total Hip Arthroplasty
Status: COMPLETED
Conditions: Pain Disorder|Sensory Deficit
Interventions: PROCEDURE: Fascia iliaca compartment block|PROCEDURE: Fascia Iliaca compartment block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimization of Postoperative Bowel Habits
Status: NOT_YET_RECRUITING
Conditions: Constipation
Interventions: DIETARY_SUPPLEMENT: Senna Tab|DIETARY_SUPPLEMENT: Dulcolax Suppositories
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: aMAZE Study: LAA Ligation Adjunctive to PVI for Persistent or Longstanding Persistent Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DEVICE: LARIAT + PVI|DEVICE: Pulmonary Vein Isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combining Nutrition Supplementation With an Exercise Program in Elderly Malnourished Frail Patients After Hospital Stay
Status: UNKNOWN
Conditions: Frailty|Sarcopenia|Malnutrition; Protein
Interventions: COMBINATION_PRODUCT: Intervention consisting of a multicomponent exercise program combined with an oral nutritional supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placebo Controlled Evaluation of Sedation and Physiological Response to Intranasal Dexmedetomidine in Severe COPD
Status: WITHDRAWN
Conditions: COPD
Interventions: DRUG: IN-DEX 1.0 mcg/kg, intranasal saline|DRUG: IN-DEX 1.5 mcg/kg, intranasal saline|DRUG: Placebo - Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A 16 Weeks Study on Efficacy and Safety of Two Doses of Empagliflozin (BI 10773) (Once Daily Versus Twice Daily) in Patients With Type 2 Diabetes Mellitus and Preexisting Metformin Therapy
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: empagliflozin (low dose qd)|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo|DRUG: Empagliflozin (high dose qd)|DRUG: empagliflozin (high dose bid)|DRUG: Placebo|DRUG: empagliflozin (low dose bid)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Oncolytic Adenovirus Combined With PD-1 Inhibitor in Patients With Non-muscle-invasive Bladder Cancer
Status: RECRUITING
Conditions: Bladder Cancer
Interventions: DRUG: H101, Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Statins on Glucose Homeostasis in Subjects With Impaired Fasting Glucose
Status: UNKNOWN
Conditions: Diabetes
Interventions: DRUG: Pravastatin|DRUG: Rosuvastatin|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Soybean Based Diets and CVD Risk Factors
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: OTHER: Diet: soybeans and products made thereof|OTHER: Diet: soybean flour and products made thereof|OTHER: Diet: soybean milk|OTHER: Diet: Animal protein based diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: STEMI Treated With a Polymer-free Sirolimus-coated Stent and P2Y12 Inhibitor-based SAPT Versus Conventional DAPT
Status: NOT_YET_RECRUITING
Conditions: ST Elevation Myocardial Infarction
Interventions: DEVICE: Successful primary PCI, defined as primary PCI of the culprit lesion with ≥1 Abluminus NP polymer-free sirolimus-based nanocarrier eluting stent (Concept Medical Inc., India) implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Efficacy of Canakinumab in Pediatric Patients With Colchicine Intolerant or Colchicine Resistant Familial Mediterranean Fever (FMF)
Status: COMPLETED
Conditions: Colchicine Resistant/Intolerant Familial Mediterranean Fever
Interventions: DRUG: Canakinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Nivolumab Plus Bevacizumab Combined With Chemotherapy Before Surgery in Patients With pMMR/MSS Colorectal Cancer Liver Metastases
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer Liver Metastases
Interventions: DRUG: CapOx(Capecitabine+ Oxaliplatin)|DRUG: Bevacizumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remission in Subjects With Crohn's Disease, 1 Year Phase
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: Double-blind (DB) adalimumab placebo|BIOLOGICAL: DB adalimumab 40 mg eow|BIOLOGICAL: DB adalimumab 40 mg ew|BIOLOGICAL: OL adalimumab 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Resistance Training on Pain, Function and Work Ability in Patients With Moderate to Severe Neck Pain
Status: COMPLETED
Conditions: Neck Pain
Interventions: BEHAVIORAL: High-intensity resistance training|BEHAVIORAL: General physical activity|BEHAVIORAL: Multidisciplinary rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Topical 1% Methotrexate Gel Versus Clobetasol Propionate in Patients With Psoriasis
Status: COMPLETED
Conditions: Pilot Study|Psoriasis
Interventions: DRUG: topical 1% methotrexate gel|DRUG: clobetasol propionate 0.05% ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Specialized Radiation Therapy in Treating Patients With Stage II, Stage III, Stage IV, or Recurrent Non-Small Cell Lung Cancer and Poor Performance Status
Status: COMPLETED
Conditions: Lung Cancer
Interventions: RADIATION: hypofractionated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Anti-Androgens in Pilonidal Sinus Disease
Status: NOT_YET_RECRUITING
Conditions: Pilonidal Disease|Pilonidal Disease of Natal Cleft|Pilonidal Sinus|Pilonidal Cyst
Interventions: DRUG: 1% Clascoterone|DRUG: Vehicle Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rational-emotional Behavioral Therapy (REBT) in Patients With Osteoarthritis and Concomitant Diseases Before Arthroplasty
Status: COMPLETED
Conditions: Depression, Anxiety|Pain
Interventions: BEHAVIORAL: REBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation of Lobaplatin Concurrent With IMRT for the Treatment of NPC: A Phase I Clinical Trial
Status: COMPLETED
Conditions: Acute Toxic Effects|Tumor Responses
Interventions: DRUG: Lobaplatin|DEVICE: linear accelerator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of TIVA With Propofol Versus Inhalational Anaesthesia on Postoperative Pain After Hepatectomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Primary and Secondary Prevention of Type 2 Diabetes Mellitus in Clark County
Status: NOT_YET_RECRUITING
Conditions: At Risk for Type 2 Diabetes Mellitus|Pre Diabetes
Interventions: BEHAVIORAL: Cooking Matters for Adults (CMA+)|BEHAVIORAL: Cooking Matters for Adults (CMA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Disconnecting Pulmonary Vagus Nerve Branch on Chronic Cough After Unilateral Thoracoscopic Lobectomy
Status: COMPLETED
Conditions: Postoperative Chronic Cough
Interventions: PROCEDURE: disconnect pulmonary vague nerve branches
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Z Stitch Early Bed Rest Assessment Study
Status: RECRUITING
Conditions: Atrial Fibrillation|Atrial Flutter|Supraventricular Tachycardia|Syncope|Ventricular Tachycardia
Interventions: OTHER: Early mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Hydromorphone-ropivacaine Versus Sufentanil-ropivacaine for Epidural Labor Analgesia
Status: RECRUITING
Conditions: Analgesia|Labor Pain
Interventions: DRUG: Hydromorphone|DRUG: Sufentanil|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Refractive Accuracy of Argos in Conjunction With the Alcon Vision Suite Following Implantation of Presbyopia Correcting IOLs
Status: RECRUITING
Conditions: Cataract
Interventions: DEVICE: Clareon PanOptix and AcrySof Vivity IOL implantation Alcon Vision Suite and Argos biometer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Pola-RCHP-X vs Pola-RCHP in Untreated DLBCL
Status: NOT_YET_RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Polatuzumab vedotin|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Prednisone|DRUG: Acalabrutinib|DRUG: Lenalidomide|DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Erythropoietin on Cognition and Neural Activity in Mood Disorders
Status: COMPLETED
Conditions: Bipolar Disorder|Cognitive Impairment|Unipolar Depression
Interventions: DRUG: Erythropoietin|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of a Video Cell Phone Reminder System on Glycemic Control in Patients With Diabetes Mellitus
Status: UNKNOWN
Conditions: Diabetes Mellitus
Interventions: DEVICE: cell phone delivered tele-educational|DEVICE: cell phone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Pilot Test of the Relaxation Response Resiliency Program (3RP) in Spanish Speaking World Trade Center Survivors With Post Traumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: Post Traumatic Stress Disorder (PTSD)
Interventions: BEHAVIORAL: 3 RP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Impact of the Use of Alternative and Complementary Therapies on Therapeutic Adherence in Patients Treated With taMoxifen for Early Stage Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: OTHER: Treatment requiring adjuvant Hormonal Therapy (HT) with tamoxifen.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prospective Treatment Algorithm Guiding Repair of Severe Ischemic Mitral Regurgitation
Status: ACTIVE_NOT_RECRUITING
Conditions: Mitral Regurgitation
Interventions: PROCEDURE: Treatment Algorithm|PROCEDURE: No Treatment Algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Polyglutamate Paclitaxel Compared With Gemcitabine or Vinorelbine in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: paclitaxel poliglumex|DRUG: vinorelbine tartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Eluting Balloon Angioplasty for Recurrent Cephalic Arch Stenosis in Dialysis Fistulas
Status: TERMINATED
Conditions: Dialysis Access Dysfunction
Interventions: DRUG: paclitaxel (Cardionovum Legflow drug eluting balloon)|DEVICE: Balloon angioplasty (Bard Dorado)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid in Total Hip Arthroplasty.
Status: COMPLETED
Conditions: Hip Arthroplasty
Interventions: DRUG: Active comparator : Tranexamic Acid (Exacyl)|DRUG: Placebo comparator : physiologic serum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Thoracic Echography for Pleuroparenchymatous Anomaly Diagnosis Complicating Bronchiolitis: BronchioIUS
Status: TERMINATED
Conditions: Bronchiolitis
Interventions: RADIATION: radiology
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Investigating Interventions to Reduce Residual Opioids in the Home Following Legitimate Opioid Prescribing in Children.
Status: COMPLETED
Conditions: Opioid Use, Unspecified
Interventions: OTHER: Medication take back|OTHER: Medication home disposal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Salivary RNA in Subjects Scheduled for Surgery for a Gynecologic Pathology
Status: NOT_YET_RECRUITING
Conditions: Gynecologic Disease|Gynecologic Cancer|Endometriosis|Ovarian Cancer|Cyst Ovary|Fibroid|Cervical Cancer|Uterine Cancer
Interventions: DIAGNOSTIC_TEST: Saliva sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Evaluating Levonorgestrel and Ethinyl Estradiol for Oral Contraception
Status: UNKNOWN
Conditions: Oral Contraceptive
Interventions: DRUG: Levonorgestrel 100 mcg and Ethinyl Estradiol 20 mcg|DRUG: Levonorgestrel 150 mcg and Ethinyl Estradiol 30 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Risk Assessment for Patients With Rheumatoid Arthritis Arthritis:
Status: ACTIVE_NOT_RECRUITING
Conditions: Rheumatoid Arthritis|Cardiovascular Diseases|Hyperlipidemias
Interventions: BEHAVIORAL: Cardiovascular Risk Assessment for Patients with Rheumatoid Arthritis|BEHAVIORAL: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Effect of Albumin Administration on Vasopressor Duration in Resolving Septic Shock
Status: TERMINATED
Conditions: Shock, Septic
Interventions: DRUG: 25% Albumin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the PI-RADS v2.1 Score Using Multiple Readers
Status: COMPLETED
Conditions: Prostate Cancer|Urological Cancer
Interventions: OTHER: Assessment of the accuracy of the PI-RADS v2.1 score for predicting the presence of ISUP ≥2 prostate cancer at subsequent biopsy in the dataset of the 171 MRIs for 21 different readers.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cranial Blocks for Postoperative Anesthesia
Status: TERMINATED
Conditions: Craniotomy Surgery
Interventions: DRUG: Liposomal bupivacaine|DRUG: Bupivacaine Injection|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Standard Dose Versus High Dose and Versus Extended Standard Dose Radium-223 Dichloride in Castration-resistant Prostate Cancer Metastatic to the Bone
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: Radium-223 dichloride (Xofigo, BAY88-8223)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Individualized Music Listening for People With Dementia on Anxiety: A Quasi-experimental Study
Status: COMPLETED
Conditions: Music Listening
Interventions: OTHER: Individualized music listening (IML)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: TwiFlow Thrombectomy Catheter sYstem for Acute Pulmonary Embolism (Twi-TYPE Study)
Status: NOT_YET_RECRUITING
Conditions: Acute Pulmonary Embolism
Interventions: DEVICE: TwiFlow-Thrombectomy Catheter System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exemestane in Treating Postmenopausal Women With Stage IV Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: exemestane|OTHER: laboratory biomarker analysis|PROCEDURE: quality-of-life assessment|OTHER: immunohistochemistry staining method
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Dose Methylprednisolone Verses Low Dose in Correction of Congenital Acynotic Heart Disease
Status: UNKNOWN
Conditions: Anesthesia
Interventions: DRUG: methyl prednisolone|DRUG: Methyl Prednisolonate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Interleukin-1 Receptor Antagonism on Hyperandrogenemia in Women With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: IL-1 receptor antagonist Anakinra
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Lactose Intolerance on Gastrointestinal Function and Symptoms in a Chinese Population
Status: UNKNOWN
Conditions: Lactose Intolerance|Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: dietary restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Testing the Addition of the AKT Inhibitor, Ipatasertib, to Treatment With the Hormonal Agent Megestrol Acetate for Recurrent or Metastatic Endometrial Cancers
Status: RECRUITING
Conditions: FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma|FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma|Metastatic Endometrial Endometrioid Adenocarcinoma|Recurrent Endometrial Endometrioid Adenocarcinoma|Stage IV Uterine Corpus Cancer AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Ipatasertib|PROCEDURE: Magnetic Resonance Imaging|DRUG: Megestrol Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Continuous Adductor Canal Block for Analgesia After Total Knee Replacement: Comparison of Short-axis and Long-axis Techniques
Status: COMPLETED
Conditions: Total Knee Arthroplasty|Analgesia|Nerve Block
Interventions: PROCEDURE: ultrasound guided long axis placement of adductor canal catheter|PROCEDURE: ultrasound guided short axis placement of adductor canal catheter|DEVICE: Philip CX 50 Ultrasound Scanner|DEVICE: PAJUNK Contiplex S Catheter|DRUG: Ropivocaine|DRUG: rescue sulfentanil given postoperatively as PICA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Open-label Long-term Study of Adjunctive Brivaracetam in Pediatric Subjects With Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Brivaracetam (BRV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of 13-valent Pneumococcal Conjugate Vaccine Among HIV-infected Adults
Status: COMPLETED
Conditions: Streptococcal Pneumonia|HIV/AIDS
Interventions: BIOLOGICAL: Prevenar13
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: e- Ab Sensor-based Real-time Detection of Oncogenic Human Papilloma Viruses
Status: UNKNOWN
Conditions: Cervical Cancer|Human Papilloma Virus Infection
Interventions: DEVICE: Electrosensing antibody probing system (e- Ab sensor)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Warming Efficiency of Warm Compresses Versus BLEPHASTEAM® in Eyelid Therapy
Status: COMPLETED
Conditions: Eyelid Diseases
Interventions: DEVICE: Warming goggles|DEVICE: warm and moist compresses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Patient Comfort and Safety Between Iodixanol and Iopamidol in Patients Undergoing Peripheral Arteriography
Status: COMPLETED
Conditions: Drug Safety
Interventions: DRUG: Iodixanol|DRUG: Iopamidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Field Evaluation of Two Topically Applied Insect Repellent Products Containing IR3535 Against Mosquitos in Louisiana
Status: UNKNOWN
Conditions: Bites and Stings
Interventions: OTHER: Repellent lotion|OTHER: Repellent Wipe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Safety, Tolerability, and Efficacy of Secukinumab in Subjects With Moderate to Severe Palmoplantar Psoriasis
Status: COMPLETED
Conditions: Moderate to Severe Palmoplantar Psoriasis
Interventions: BIOLOGICAL: secukinumab 150 mg|BIOLOGICAL: secukinumab 300 mg|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study With Lidocaine 5% Medicated Plaster in Patients Suffering From Postherpetic Neuralgia
Status: COMPLETED
Conditions: Post Herpetic Neuralgia
Interventions: DRUG: Lidocaine 5% medicated plaster
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Esomeprazole Magnesium Dihydrate 40 mg Tablets Relative to Nexium 40 mg Tablets Under Fasting Condition
Status: NOT_YET_RECRUITING
Conditions: Healthy Subjects
Interventions: DRUG: Esomeprazole magnesium dihydrate-Test product|DRUG: Esomeprazole magnesium dihydrate-Reference product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Efficacy and Safety of VX-864 in Subjects With the PiZZ Genotype
Status: COMPLETED
Conditions: Alpha1-Antitrypsin Deficiency
Interventions: DRUG: VX-864|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: E-learning Proficiency Based Progression Training Programme for Clinical Communication on ISBAR Performance (eISBAR)
Status: COMPLETED
Conditions: Communication
Interventions: BEHAVIORAL: ePBP: eProficiency Based Progression|BEHAVIORAL: eS: eScenarios|BEHAVIORAL: HSE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: CERebrolysin In CADASIL
Status: RECRUITING
Conditions: Cadasil
Interventions: DRUG: Cerebrolysin|DRUG: 0.9 % NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of HX106 on Improvement in Cognitive-Bio-Markers of Memory Function
Status: COMPLETED
Conditions: Healthy Adults With Subjective Memory Complaints
Interventions: DIETARY_SUPPLEMENT: HX106 590mg|DIETARY_SUPPLEMENT: HX106 1180mg|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidinine in the Prevention of Postoperative Delirium in the Intensive Care Unit After Cardiac Surgery
Status: RECRUITING
Conditions: Intensive Care Unit Delirium
Interventions: DRUG: Dexmedetomidine|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study Comparing Zanubrutinib + Rituximab Versus Bendamustine + Rituximab in Participants With Untreated Mantle Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Mantle Cell Lymphoma; Non-Hodgkin Lymphoma
Interventions: DRUG: zanubrutinib|DRUG: bendamustine|DRUG: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION VERSUS DISTRACTIVE TECHNIQUES ON ARTERIOVENOUS FISTULA PUNCTURE PAIN IN HEMODIALYSIS PATIENTS
Status: UNKNOWN
Conditions: TENS, Distractive Techniques, Arteriovenous Fistula, Puncture Pain, Hemodialysis
Interventions: OTHER: TENS, Distractive techniques, cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study on Efficacy & Safety Profile of Propionyl-L-carnitine Tablets for Peripheral Arterial Diseases
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DRUG: Propionyl-L-carnitine Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Altered Immune Response to Exercise in Patients With Fibromyalgia Before and After a Mind-body Intervention
Status: UNKNOWN
Conditions: Fibromyalgia
Interventions: OTHER: Mind-body exercise|OTHER: Light mobility exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Estimation of Kidney Function Through Combination of Renal Biomarkers in Blood and Urine of Healthy Infants and Children.
Status: COMPLETED
Conditions: Renal Biomarkers in Children
Interventions: OTHER: blood test for renal biomarkers (creatinine, cystatin C, Neutrophil gelatinase-associated lipocalin, beta-trace protein, beta-2 microglobulin, uromodulin)|OTHER: urine test for renal biomarkers (creatinine, cystatin C, Neutrophil gelatinase-associated lipocalin, beta-trace protein beta-2 microglobulin, uromodulin, albumin)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Multipart, Open-label Study to Evaluate the Safety and Efficacy of ABT-450/r/ABT-267 With and Without ABT-333 Coadministered With and Without Ribavirin in Adult With Genotype 1 or 4 Hepatitis C Virus (HCV) Infection and Human Immunodeficiency Virus, Type 1 Coinfection
Status: COMPLETED
Conditions: Hepatitis C Virus Infection|Human Immunodeficiency Virus Infection|Chronic Hepatitis C|Compensated Cirrhosis and Non-cirrhotics
Interventions: DRUG: ABT-450/r/ABT-267|DRUG: ABT-333|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexketoprofen Trometamol in Postoperative Endodontic Pain
Status: COMPLETED
Conditions: Irreversible Pulpitis
Interventions: DRUG: Dexketoprofen trometamol|DRUG: Ibuprofen|DRUG: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Soothing and Barrier Restoration Activity of a Body Cream for Atopic Skin
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: OTHER: P927 - LICHTENA DermAD CREMA CORPO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketogenic Diet Treatment of Obesity With Co-morbid Type 2 Diabetes Mellitus and/or Obstructive Sleep Apnea
Status: UNKNOWN
Conditions: Obesity|Diabetes|Obstructive Sleep Apnea
Interventions: OTHER: Ketogenic diet|DRUG: Orlistat|OTHER: Standardized diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multifidus & Gastrocnemius Muscle Thickness & Postural Stability in Spinal Cord Injury Patients: A Correlational Study
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injuries
Interventions: OTHER: Measurement of multifidus and gastrocnemius muscle thickness with Ultrasound|OTHER: Berg Balance Scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Activity of a Pharmacological "Anticellulitis" Product vs. a Reference Product on the Market
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: ANTICELLULITE GMG GIULIANI Cream and SOMATOLINE Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluating the Safety and Immunogenicity of 3 COVID-19 SARS-CoV-2 RNA Vaccines in Healthy Adults
Status: COMPLETED
Conditions: COVID-19|SARS-CoV-2 Infection|Corona Virus Infection
Interventions: BIOLOGICAL: ARCT-165|BIOLOGICAL: ARCT-154|BIOLOGICAL: ARCT-021
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Combination Study to Determine the Safety and Efficacy of Panzem NCD With Avastin in Metastatic Carcinoid Tumors
Status: COMPLETED
Conditions: Carcinoid Tumor
Interventions: DRUG: Panzem (2-methoxyestradiol) NCD, Avastin (Bevacizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adoptive Cell Therapy Following a Non-myeloablative, Lymphodepleting Induction Regimen in Metastatic Melanoma Patients
Status: RECRUITING
Conditions: Malignant Melanoma Stage IV
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide|BIOLOGICAL: TIL|DRUG: IL-2|DRUG: Nivolumab|DRUG: Ipilimumab|DRUG: FMT Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of On-Line Hemodiafiltration(HDF) on Vascular Health in Chronic Hemodialysis Patients
Status: UNKNOWN
Conditions: End Stage Renal Disease|Hemodialysis
Interventions: PROCEDURE: On-line hemodiafiltration|PROCEDURE: Low flux hemodialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Denervation in Patients With Chronic Heart Failure With Preserved Ejection Fraction
Status: RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction|Renal Denervation
Interventions: PROCEDURE: Sham procedure and maintenance of heart failure medications|PROCEDURE: Renal denervation and maintenance of heart failure medications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Incidence of MIS-C and Other Complications Following SARS-CoV-2 Infection
Status: RECRUITING
Conditions: SARS CoV 2 Infection|Multisystem Inflammatory Disease, Pediatric, COVID-19 Related|Multisystem Inflammatory Syndrome in Children|COVID-19 Pandemic
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transdermal Trigeminal Electrical Neuromodulation on Mild Cognitive Impairment With Insomnia
Status: RECRUITING
Conditions: Insomnia|Alzheimer Disease|Mild Cognitive Impairment|Amyloid
Interventions: DEVICE: Transdermal trigeminal electrical neuromodulation(Cefaly)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mental Stress and Myocardial Ischemia After MI: Sex Differences, Mechanisms and Prognosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Myocardial Infarction
Interventions: OTHER: Stress Challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multi-center Application of Bivalirudin in Left Atrial Appendage Occlusion
Status: UNKNOWN
Conditions: Evaluate the Safety and Efficacy of Bivalirudin in Decreasing Bleeding Risk
Interventions: DRUG: Bivalirudin|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Steady State Blood Volume Maps Using Ferumoxytol Non-stoichiometric Magnetite MRI in Imaging Patients With Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma
Interventions: PROCEDURE: Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging|DRUG: Ferumoxytol|DRUG: Gadoteridol|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Adding Lidocaine to Dexamethasone in Intra-tympanic Injection for Management of Tinnitus
Status: COMPLETED
Conditions: Tinnitus
Interventions: DRUG: Intra-tympanic injection of drugs|OTHER: Data management of intratympanic drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study Of Pharmacokinetics, Pharmacodynamics And Safety Of Adding ETC-1002 To Atorvastatin 80 mg
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DRUG: ETC-1002|DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Epidural Association of Morphine and Ropivacaine for Cancer Pain Treatment
Status: UNKNOWN
Conditions: Cancer Pain|Opioid Use|Cost Analysis|Palliative Care|Epidural Route|Morphine-ropivacaine Association|Quality of Life|Rational Use of Medication
Interventions: DEVICE: Interventional Group (Epidural morphine)|DRUG: Control Group (Oral morphine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electronic Referral and Booking of Outpatient Day Case Surgery Compared With Traditional Referral Routines.
Status: COMPLETED
Conditions: Referral and Consultation|Telemedicine|Surgery, Outpatient|Surgery, Day|Medical Records Systems, Computerized|Health Services Research|Health Care Surveys
Interventions: BEHAVIORAL: one stop (Electronic standardised referrals and appointment bookings)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Chewing Duration on Blood Glucose Levels
Status: COMPLETED
Conditions: Glucose, High Blood|Glucose, Low Blood
Interventions: OTHER: Low glycaemic load, high fibrous product|OTHER: High glycaemic load, low fibrous product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dural Puncture Epidural Anesthesia Versus Traditional Spinal Anesthesia for Rigid Cystoscopy
Status: COMPLETED
Conditions: Dural Puncture Epidural Anesthesia|Spinal Anesthesia|Rigid Cystoscopy
Interventions: DRUG: hyperbaric bupivacaine and fentanyl|DRUG: plain bupivacaine and fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy Study of Selective Tibial Neurotomy in the Treatment of the Spastic Equinovarus Foot Among Adult Hemiplegic Patients
Status: COMPLETED
Conditions: Spastic Equinovarus Foot|Stroke
Interventions: PROCEDURE: Selective tibial neurotomy|DRUG: Botulinum toxin injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Phase II Study of Nivolumab in Adult Participants With Progessive/ Recurrent Meningioma
Status: RECRUITING
Conditions: Meningiomas
Interventions: DRUG: Nivolumab - 240 mg|DRUG: Ipilimumab - 1 mg/kg|DRUG: Nivolumab - 480 mg|DRUG: Nivolumab - 3 mg/kg|RADIATION: External Beam RT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Disitamab Vedotin Combined With Sintilimab
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Disitamab Vedotin combined with Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Safety and Efficacy of BMN 111 in Infants and Young Children With Achondroplasia
Status: COMPLETED
Conditions: Achondroplasia
Interventions: DRUG: BMN 111|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Surgery or Radiation Therapy in Treating Patients With Stage 0, Stage I, or Stage II Laryngeal Cancer of the Glottis
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: PROCEDURE: endoscopic surgery|PROCEDURE: laser surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Adjunctive Vortioxetine in Schizophrenia
Status: ACTIVE_NOT_RECRUITING
Conditions: Schizophrenia|Negative Symptoms
Interventions: DRUG: Vortioxetine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fluorine F 18 EF5 Positron Emission Tomography in Assessing Hypoxia in Patients With Newly Diagnosed Stage I, Stage II, Stage III, or Stage IV Head or Neck Squamous Cell Cancer of the Oral Cavity, Oropharynx, and Larynx
Status: COMPLETED
Conditions: Squamous Cell Carcinoma
Interventions: DRUG: fluorine F18 EF5|PROCEDURE: immunohistochemistry staining method|PROCEDURE: biopsy|PROCEDURE: Positron Emission tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC