pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: ACute Uncomplicated Type b Aortic Dissection: Endovascular Repair vs. Best Medical Therapy
Status: RECRUITING
Conditions: Distal Aortic Dissection|Dissection, Aortic Acute|Acute Type B Aortic Dissection (Uncomplicated)
Interventions: DEVICE: BMT+TEVAR|OTHER: BMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Investigate Recovery From COVID-19 With C21 in Adult Subjects
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: C21|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of the Drug Impaired Driving Scenario (DIDS) on the CRCDS-miniSim
Status: COMPLETED
Conditions: Driving Behavior|Driving Under the Influence
Interventions: DRUG: Placebo (Lactose) Capsule|DRUG: 0.75 mg Alprazolam Capsule|DRUG: Cannabis (6.18% THC / <0.025% CBD)|DRUG: Cannabis (0%/ THC / 0% CBD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Asthma Management Program to Promote Activity for Students in Schools (Asthma-PASS)
Status: RECRUITING
Conditions: Asthma in Children
Interventions: BEHAVIORAL: Asthma-PASS|BEHAVIORAL: Basic Asthma Management (AM)|BEHAVIORAL: Child/Caregiver Education session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Project Wellness Enhancement: Increasing Health Care Choice and Outcomes for People With Mental Illness
Status: COMPLETED
Conditions: Mental Health Wellness 1|Mental Illnesses|Other Diagnoses, Comorbidities, and Complications | Patient
Interventions: BEHAVIORAL: Peer whole health intervention|BEHAVIORAL: EBPs at Wellness Center
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Translational Approach to the Understanding and Treatment of Obsessive-Compulsive Disorder (OCD). Can D-Cycloserine Enhance and Stabilize the Treatment-response in Relapsed and Non-responding OCD-patients?
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: DRUG: D-Cycloserine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Conditioned Plasma (ACP) Intra-articular (IA) Injections for Knee Osteoarthritis (OA)
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: ACP|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Effects of Aerobic and Strength Training in Hypertensive Middle-aged Individuals
Status: COMPLETED
Conditions: Arterial Hypertension
Interventions: OTHER: Strength training group|OTHER: Aerobic Training Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Find the Best Dose of Fezolinetant to Treat Hot Flashes in Women Going Through Menopause
Status: COMPLETED
Conditions: Hot Flashes
Interventions: DRUG: Fezolinetant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Low Dose Radiotherapy Concurrent SBRT and PD-1 Inhibitors in Advanced NSCLC.
Status: RECRUITING
Conditions: NSCLC|Low Dose Radiotherapy|Stereotactic Body Radiotherapy|PD-1 Inhibitor
Interventions: RADIATION: Low Dose Radiotherapy|RADIATION: stereotactic body radiation therapy|DRUG: PD-1 Inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Tolerability of AC-1101 Topical Gel in Patients With Granuloma Annulare
Status: RECRUITING
Conditions: Granuloma Annulare
Interventions: DRUG: AC-1101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Community Youth Development Study: A Test of Communities That Care
Status: ACTIVE_NOT_RECRUITING
Conditions: Substance Abuse|Juvenile Delinquency|Sexual Behavior|Criminal Behavior|Violence|Depression|Anxiety|Suicide|Sexually Transmitted Infection|Educational Attainment
Interventions: BEHAVIORAL: Communities That Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Runimotamab in Participants With Locally Advanced or Metastatic HER2-Expressing Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumors
Interventions: DRUG: Runimotamab|DRUG: Trastuzumab|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Micropulsed Laser Trabeculoplasty Using Different Parameters
Status: UNKNOWN
Conditions: Glaucoma, Open-Angle
Interventions: PROCEDURE: Micropulsed laser trabeculoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Colchicine for the Treatment of Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis|Osteo Arthritis Knee
Interventions: DRUG: Colchicine 0.8 mg or 0.6 mg orally once daily|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Oral Hygiene With Chlorhexidine and Incidence of Ventilator-Associated Pneumonia in Children Submitted to Heart Surgery
Status: COMPLETED
Conditions: Ventilator Associated Pneumonia|Nosocomial Pneumonia|Heart Surgery
Interventions: OTHER: oral hygiene|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Implementing a Family Caregiver Checklist in Primary Care: A Pilot Study
Status: RECRUITING
Conditions: Caregiver Burnout
Interventions: BEHAVIORAL: Collaborative Healthcare Encounters with Caregivers (CHEC)|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study of Current Practice Which Compare the Rate of Prostate Cancer by Using 2 Kind of Transrectal Biopsies: 3 by IRM-echography Image Fusion and 12 Systematized Guided Echographies.
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: systematic biopsies|PROCEDURE: Targeted biopsies guided by a fusion of MRI and ultrasound- images
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An Open-label Extension Study of Certolizumab Pegol in Chinese Patients With Rheumatoid Arthritis Who Enrolled in RA0044
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Certolizumab Pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Calculous Pyonephrosis With 0.5% Iodophors for I-stage PCNL
Status: UNKNOWN
Conditions: Urolithiasis
Interventions: COMBINATION_PRODUCT: 0.5% Iodophors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PREMOD2 With Near Infrared Spectroscopy Sub-study
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypoxia, Brain|Premature Birth
Interventions: PROCEDURE: Umbilical cord milking|PROCEDURE: Delayed Cord Clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Remote Ischemic Conditioning in the Treatment of Essential Hypertension (RICBP-EH)
Status: RECRUITING
Conditions: Essential Hypertension
Interventions: PROCEDURE: Remote ischemic conditioning|PROCEDURE: Sham remote ischemic conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ustekinumab (Anti-IL-12/23p40 Monoclonal Antibody) in Patients With Leukocyte Adhesion Deficiency Type 1 (LAD1) Who Have Inflammatory Pathology
Status: RECRUITING
Conditions: LAD1
Interventions: DRUG: Ustekinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ED90 of Bupivacaine After Lidocaine Test Dose With DPE and EPL
Status: NOT_YET_RECRUITING
Conditions: Labor Pain
Interventions: DRUG: Bupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Stable Both-Bone Midshaft Forearm Fractures in Children
Status: UNKNOWN
Conditions: Fracture|Forearm|Midshaft|Child|Treatment
Interventions: DEVICE: above or below elbow cast for the last 3 weeks of treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: VCRC Patient Contact Registry Patient-Reported Data Validation Study
Status: COMPLETED
Conditions: Behcet's Disease|Churg-Strauss Syndrome|Giant Cell Arteritis|Wegener Granulomatosis|Microscopic Polyangiitis|Polyarteritis Nodosa|Takayasu's Arteritis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: REPArE: Rating Evaluations in Psoriatic Arthritis (PsA) With Etanercept (Enbrel®)
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Investigate the Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of JP-1366 Oral Administration in Healthy Male Subjects
Status: COMPLETED
Conditions: Anti-Ulcer Agents
Interventions: DRUG: Cohort 1 (JP-1366 A mg)|DRUG: Cohort 2 (JP-1366 B mg)|DRUG: Cohort 3 (JP-1366 C mg)|DRUG: Cohort 4 (JP-1366 D mg)|DRUG: Cohort 5 (JP-1366 E mg)|DRUG: Cohort 6 (JP-1366 F mg)|DRUG: Cohort 7 (JP-1366 G mg)|DRUG: Cohort 8 (JP-1366 H mg)|DRUG: Cohort 9 (JP-1366 I mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing the Glycaemic Control of Levemir® Administered Once Daily According to Two Insulin Detemir Titration Algorithms After 20 Weeks in Subjects With Type 2 Diabetes Mellitus Inadequately Controlled on Metformin Treatment With or Without Other Anti-diabetic Drugs (OADs)
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin detemir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Evaluate the Revoxa™ System in Hypoxic Patients
Status: COMPLETED
Conditions: Hypoxemia
Interventions: DEVICE: Conventional (low flow) oxygen delivery via nasal cannula|DEVICE: Revoxa Oxygen Rebrearther
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Insulin Iontophoresis Mixed With Oleic Acid Versus Topical Insulin in Patients With Chronic Diabetic Foot Ulcer
Status: UNKNOWN
Conditions: Diabetes Mellitus
Interventions: OTHER: insulin iontophoresis|OTHER: topical insulin|OTHER: conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Asian Flushing Syndrome With Topical Alpha Agonists
Status: COMPLETED
Conditions: Flushing|Alcohol-Related Disorders|Aldehyde Dehydrogenase Deficiency
Interventions: DRUG: Brimonidine Tartrate|DRUG: Placebo Vehicle Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects Of Vitamin D On Bone, Muscle, And Adipose Tissue In Obese Subjects
Status: RECRUITING
Conditions: Musculoskeletal Diseases|Inflammation|Sarcopenic Obesity
Interventions: DRUG: Cholecalciferol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of a New EUS Guided Biopsy Needle (SharkCore) Comparing to Standard EUS Needle (ProCore)
Status: WITHDRAWN
Conditions: Mesenchymal Tumor|Autoimmune Pancreatitis|Lymphoma|Solid Tumors
Interventions: PROCEDURE: EUS-FNB with ProCore needle|PROCEDURE: EUS-FNB with SharkCore needle|DEVICE: ProCore needle|DEVICE: SharkCore needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Needling Techniques for Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis|Kidney Yin Deficiency|Kidney Yang Deficiency
Interventions: PROCEDURE: Acupuncture|DRUG: Conventional Medical Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Infection Control Using H2O2 Mouth Wash and Nasal Spray
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DEVICE: Hydrogen peroxide|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Immunogenicity of a DNA-based Vaccine (COVIGEN) in Healthy Volunteers
Status: COMPLETED
Conditions: SARS-CoV2 COVID-19
Interventions: BIOLOGICAL: COVIGEN C19 0.8 mg ID or Placebo ID|BIOLOGICAL: COVIGEN C19 2.0 mg IM or Placebo IM|BIOLOGICAL: COVIGEN C19 4.0 mg IM or Placebo IM|BIOLOGICAL: COVIGEN C20 1.0mg vaccine ID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Introduction of MMS to Antenatal Care in Bamako, Mali
Status: COMPLETED
Conditions: Adherence, Medication
Interventions: DIETARY_SUPPLEMENT: United Nations International Multiple Micronutrient Antenatal Preparation (UNIMMAP) MMS|DIETARY_SUPPLEMENT: Iron Folic Acid Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy of Low-dose Ticagrelor in Chinese Patients With Stable Coronary Artery Disease
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: low-dose ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Intensities of Repeated Low-Level Red-Light Therapy on Choroidal and Retinal Blood Flow Among Adults
Status: RECRUITING
Conditions: Choroid|Retina
Interventions: DEVICE: RLRL device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TOCILIZUMAB IN FIBROUS DYSPLASIA OF BONE
Status: COMPLETED
Conditions: Fibrous Dysplasia of Bone
Interventions: DRUG: Tocilizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Enhanced Neurostimulation for Anorexia
Status: RECRUITING
Conditions: Anorexia Nervosa
Interventions: DEVICE: MagPro TMS device (ARTG: 204659)|DEVICE: tDCS mini-CT Stimulator (Soterix, USA: ARTG: 284637)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Non-Invasive Acoustic Diagnostic for the Diagnosis of Coronary Artery Disease The CAD-det Validation Study
Status: UNKNOWN
Conditions: Coronary Artery Disease|Cardiovascular Diseases|Atherosclerosis|Coronary Occlusion
Interventions: DEVICE: CAD-det
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: AMPLIFY Study: Transcutaneous Spinal Direct Current Stimulation to Enhance Locomotor Rehabilitation After SCI
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: DEVICE: High Dose Intervention-tsDCS|DEVICE: Low Dose Intervention-tsDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Hypoglossal Nerve Stimulation Study (Lingual Study)
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: PROCEDURE: Transvenous hypoglossal nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effectiveness of Subcutaneous Glargine On The Time To Closure of The Anion Gap in Patients Presenting to the Emergency Department With Diabetic Keto-acidosis
Status: COMPLETED
Conditions: Diabetic Ketoacidosis
Interventions: DRUG: Insulin Glargine|DRUG: Regular Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: MSG Use With 18F-DCFPyL PET/CT Imaging
Status: COMPLETED
Conditions: Prostate Cancer|Prostate Cancer Metastatic|Prostatic Neoplasm
Interventions: DIAGNOSTIC_TEST: 18F-DCFPyL PET/CT scan|OTHER: Placebo drink|OTHER: MSG drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Servo Controlled Oxygen Targeting (SCO2T) Study: Masimo vs. Nellcor
Status: RECRUITING
Conditions: Premature|Premature Infant|Oxygen Therapy|Hypoxia|Hyperoxia|Obstetric Labor, Premature
Interventions: DEVICE: Servo control (closed-loop automatic control of the inspiratory fraction of oxygen (FiO2)) - IntellO2 OAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on Continuous Suture of Endoscopic Mucosal Defects
Status: COMPLETED
Conditions: Colonic Polyp|Gastrointestinal Neoplasms
Interventions: DEVICE: Cotinuous suture|DEVICE: Clips
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness Study of the Ivivi SofPulse for Pain Amelioration in Adults With Mild to Moderate Knee Osteoarthritis
Status: TERMINATED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Ivivi SofPulse|DEVICE: Ivivi SofPulse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Bioavailability of Naloxone Nasal Spray, Naloxone Hydrochloride (HCl) Intravenous (IV) and Intramuscular Injection (IM) in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Treatment A: Naloxone Nasal Spray|DRUG: Treatment B: Naloxone Nasal Spray|DRUG: Treatment C: Naloxone HCl Intravenous (IV) Injection|DRUG: Treatment D: Naloxone HCl Intramuscular (IM) Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Plasma Exchange With Albutein® 5% in Participants With Amyotrophic Lateral Sclerosis
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: BIOLOGICAL: Albutein 5%|PROCEDURE: Plasma Exchange
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Meditation Trial for Treating OCD
Status: COMPLETED
Conditions: OCD
Interventions: BEHAVIORAL: Kundalini Yoga Meditation|BEHAVIORAL: Relaxation Response Meditation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Home Non-invasive Ventilation for Chronic Obstructive Pulmonary Disease Patients
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease|Hypercapnic Respiratory Failure
Interventions: DEVICE: Non Invasive Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Milademetan Versus Trabectedin in Patient With Dedifferentiated Liposarcoma
Status: TERMINATED
Conditions: Dedifferentiated Liposarcoma
Interventions: DRUG: RAIN-32|DRUG: Trabectedin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent
Status: RECRUITING
Conditions: Central Nervous System (CNS) Lesions|Brain Metastases|Brain Neoplasms|Brain Neoplasms, Benign|Brain Tumor, Primary|Brain Tumor, Recurrent|Brain Tumors|Brain Cancer|Brain Tumor|Brain Neoplasm, Primary|Multiple Sclerosis|Multiple Sclerosis Brain Lesion|Neurofibroma|Acoustic Neuroma|CNS Tumor|CNS Lesion|CNS Metastases|CNS Cancer|CNS Lymphoma
Interventions: DRUG: RVP-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Prognostic Significance of Fatty Liver Disease in Bariatric Patients
Status: RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease|Metabolic Encephalopathy|Obesity, Morbid|Non-alcoholic Steatohepatitis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparing Topical Tetracaine Drops to Topical Focal Phenol for Local Anesthesia During Intratympanic Steroid Injection
Status: ACTIVE_NOT_RECRUITING
Conditions: Intratympanic Steroid Injection|Idiopathic Sudden Sensorineural Hearing Loss|Meniere Disease
Interventions: DRUG: Tetracaine 5% drops|DRUG: Phenol 90% concentration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Conversion Trial From Mycophenolate Mofetil (MMF) to Enteric-coated Mycophenolate Sodium (EC-MPS) in Stable Transplanted Patients Suffering From Gastrointestinal (GI) Adverse Events While on Mycophenolate Mofetil Therapy (MMF) Therapy
Status: COMPLETED
Conditions: Kidney Transplantation|Liver Transplantation
Interventions: DRUG: Enteric-coated Mycophenolate sodium (EC-MPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced Fluence Photodynamic Therapy (PDT) With Visudyne in Combination With Lucentis for Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Age-Related Maculopathy|Choroidal Neovascularization
Interventions: DRUG: Ranibizumab|DRUG: Verteporfin|DRUG: Verteporfin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of TRanscathetEr and Surgical Aortic BiOprosthetic Valve Thrombosis and Its TrEatment With Anticoagulation
Status: RECRUITING
Conditions: Prosthetic Valve Thrombosis
Interventions: DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone Graft Necessity in Opening-Wedge High Tibial Osteotomy
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: PROCEDURE: high tibial osteotomy|PROCEDURE: higi tibial osteotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Budesonide for Patients With Primary Sclerosing Cholangitis
Status: COMPLETED
Conditions: Cholangitis, Sclerosing|Liver Cirrhosis, Biliary
Interventions: DRUG: budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin and Gemcitabine) for Advanced Solid Tumors With Emphasis on Urothelial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Bile Duct Carcinoma|Advanced Breast Carcinoma|Advanced Cervical Carcinoma|Advanced Endometrial Carcinoma|Advanced Esophageal Carcinoma|Advanced Gastric Carcinoma|Advanced Head and Neck Carcinoma|Advanced Lung Non-Small Cell Carcinoma|Advanced Lung Small Cell Carcinoma|Advanced Malignant Solid Neoplasm|Advanced Ovarian Carcinoma|Advanced Penile Carcinoma|Advanced Pleural Malignant Mesothelioma|Advanced Urothelial Carcinoma|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Clinical Stage III Gastric Cancer AJCC v8|Clinical Stage IV Gastric Cancer AJCC v8|Stage III Cervical Cancer AJCC v8|Stage III Distal Bile Duct Cancer AJCC v8|Stage III Intrahepatic Bile Duct Cancer AJCC v8|Stage III Lung Cancer AJCC v8|Stage III Ovarian Cancer AJCC v8|Stage III Penile Cancer AJCC v8|Stage III Pleural Malignant Mesothelioma AJCC v8|Stage IV Cervical Cancer AJCC v8|Stage IV Distal Bile Duct Cancer AJCC v8|Stage IV Intrahepatic Bile Duct Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IV Ovarian Cancer AJCC v8|Stage IV Penile Cancer AJCC v8|Stage IV Pleural Malignant Mesothelioma AJCC v8|Triple-Negative Breast Carcinoma|Unresectable Urothelial Carcinoma
Interventions: DRUG: Cisplatin|DRUG: Elimusertib|DRUG: Gemcitabine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enriched Music-Supported Therapy to Restore Motor Deficits After Stroke
Status: UNKNOWN
Conditions: Stroke
Interventions: BEHAVIORAL: Enriched Music-Supported Therapy|BEHAVIORAL: Graded Repetitive Arm Supplementary Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy and the Safety of Different Schedules of Administration of Sub-lingual Immunotherapy
Status: COMPLETED
Conditions: Pollen Allergy
Interventions: BIOLOGICAL: Slit One|BIOLOGICAL: Slit One|BIOLOGICAL: Slit One ragweed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of Perioperative Steroid Dosing on Postsurgical Edema in Orthognathic Surgery
Status: COMPLETED
Conditions: Post-operative Edema|Steroid Use
Interventions: DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: FASTR: Fairly Brief Androgen Suppression and Stereotactic Radiotherapy for High Risk Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: RADIATION: Stereotactic Body Radiation|DRUG: Luteinizing Hormone Releasing Hormone (LHRH) Agonist
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Comprative Study of the Prophylactic Efficacy and a Non-comparative Study of the Immunogenicity and Safety of the Inactivated Whole-virion Concentrated Purified Coronavirus Vaccine (CoviVac)
Status: RECRUITING
Conditions: Coronavirus Infections|Vaccine
Interventions: BIOLOGICAL: CoviVac vaccine (inactivated whole-virion concentrated purified) manufactured by FSBSI "Chumakov FSC R&D IBP RAS"|OTHER: The data from volunteers from the control group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Sintilimab After Concurrent Chemoradiotherapy in Elderly Patients With Esophageal Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Esophageal Cancer|Chemoradiotherapy|Sintilimab|Immunotherapy|Elderly Patients
Interventions: DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 (BV/HSV-2) Shedding Study
Status: COMPLETED
Conditions: Bacterial Vaginosis
Interventions: DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hormone Suppression and Radiation Therapy for 6 Months With/Without Docetaxel for High Risk Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Docetaxel|DRUG: Androgen Hormonal Suppression and Radiation|DRUG: Androgen Suppression Therapy and Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Haploidentical Stem Cell Transplantation With CD3/CD19 Depletion and Reduced Intensity Conditioning in Patients With Acute Leukemia
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia
Interventions: DRUG: Fludarabine, Thiotepa, Melphalan, Thymoglobuline (ATG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutrition Education Program for Postoperative Patients With Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer|Nutrition Disorders
Interventions: OTHER: standardized nutrition education|OTHER: routine nutrition education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sputum Induction by Physiotherapy and Hypertonic Saline Techniques in Asthmatic Children
Status: COMPLETED
Conditions: Asthma
Interventions: OTHER: physiotherapy techniques|OTHER: hypertonic saline 3%|OTHER: saline + physiotherapy maneuvers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of New Specifications (38mm) of FirehawkTM in the Treatment of Coronary Heart Disease
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DEVICE: Rapamycin target-eluting coronary stent systems (38mm)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Mesenchymal Stem Cells in Knee Osteoarthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Musculoskeletal Pain|Knee Osteoarthritis|Cartilage Injury|Cartilage Degeneration
Interventions: BIOLOGICAL: Autologous Mesenchymal Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Meditation Interventions for Treatment of PTSD in Veterans
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic
Interventions: BEHAVIORAL: Mindfulness-Based Stress Reduction (MBSR)|BEHAVIORAL: Present-Centered Group Therapy (PCGT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outpatient and Home Pelvic Floor Training for Stress Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence, Stress
Interventions: OTHER: Exercises of the pelvic floor muscle at home|OTHER: Exercises of the pelvic floor muscle in the outpatient
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Two Protocols of Shock Wave Therapy for Patients With Plantar Fasciitis
Status: NOT_YET_RECRUITING
Conditions: Plantar Fasciitis
Interventions: DEVICE: High-Frequency ESWT|DEVICE: Low-Frequency ESWT Group|DEVICE: Sham ESWT Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Lidocaine Block on Gastroesophageal Reflux Disease
Status: NOT_YET_RECRUITING
Conditions: Gastroesophageal Reflux Disease
Interventions: BEHAVIORAL: Rehabilitation therapy|PROCEDURE: Injection|DRUG: Lidocaine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prone and Supine Positions in Preterm Infants Receiving Mechanical Ventilation
Status: COMPLETED
Conditions: Preterm Infant|Ventilator Lung; Newborn|Preterm Birth
Interventions: BEHAVIORAL: Group 1:Supine-Prone|BEHAVIORAL: Group 2:Prone-Supine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomized Controlled Trial of Laparoscopic Gastric Bypass Plus Omentectomy Versus Laparoscopic Gastric Bypass Alone in Improving Diabetic Indices
Status: UNKNOWN
Conditions: Diabetes|Interleukins|Cytokines
Interventions: PROCEDURE: laparoscopic gastric bypass plus omentectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comprehensive Study on Dry Eye and Ocular Surface Disease Prior and After Cataract Surgery
Status: UNKNOWN
Conditions: Dry Eye Disease|Dry Eye Syndrome|Evaporative Dry Eye|Cataract|Phacoemulsification
Interventions: DRUG: The study will include three arms, one non interventional and 2 interventions. The intervention arms will include two commercially available sodium hyaluronate 0.1% (Systane ultra plus and Hylo-comod)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sustained Acoustic Medicine (SAM) Combined With a Diclofenac Ultrasound Coupling Patch for Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteo Arthritis Knee|Arthritis
Interventions: COMBINATION_PRODUCT: Sustained Acoustic Device with 1% Diclofenac patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Eryaspase in Combination With Chemotherapy Versus Chemotherapy Alone for the Treatment of TNBC (TRYbeCA-2)
Status: TERMINATED
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: eryaspase (L-asparaginase encapsulated in red blood cells)|DRUG: Gemcitabine|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, PK and PD Study of ABX464 in Untreated HIV Patients
Status: COMPLETED
Conditions: Human Immunodeficiency Virus Infections
Interventions: DRUG: ABX464|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment of Next Science Solution on Gustilo and Anderson Type II and IIIA or IIIB Tibial Fractures
Status: TERMINATED
Conditions: Surgical Wound Infection
Interventions: DEVICE: Next Science|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Different Modes of Respiratory MuscleTraining on Respiratory Mechanics and NRD in Patient With Stable COPD.
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DEVICE: inspiratory pressure threshold device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Colloid Preload And Crystalloid Coload Versus Crystalloid Coload During Spinal Anesthesia for Cesarean Delivery
Status: COMPLETED
Conditions: Anesthesia, Spinal|Cesarean Section
Interventions: DRUG: 500 mL Colloid Preload|PROCEDURE: Spinal Anesthesia|DRUG: Intrathecal Bupivacaine|DRUG: Intrathecal Fentanyl|DRUG: 500 mL Crystalloid Coload|DRUG: 1000 mL Crystalloid Coload|PROCEDURE: Cesarean Delivery|RADIATION: Ultrasound Assessment of the Inferior Vena Cava|DRUG: Intravenous Ephedrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is Deltoid Ligament Repair for Ankle Fracture Necessary?
Status: WITHDRAWN
Conditions: Ankle Fracture
Interventions: PROCEDURE: Repair Deltoid Tendon|OTHER: Ankle Fracture Without Deltoid Tendon Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IXO+A in mCRC With Liver-only Metastases
Status: WITHDRAWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: irinotecan, capecitabine, oxaliplatin (IXO) and bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monoclonal Antibody Therapy in Relapsed Non-Hodgkin's After Chemotherapy and Autologous Stem Cell Transplantation
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|RADIATION: yttrium Y 90 ibritumomab tiuxetan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Fosciclopirox in Patients With Relapsed/Refractory Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Refractory Acute Myeloid Leukemia|Recurrent Acute Myeloid Leukemia
Interventions: DRUG: Fosciclopirox|DRUG: Fosciclopirox + Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumors|Metastatic Melanoma
Interventions: DRUG: losartan|DRUG: dextromethorphan|DRUG: caffeine|DRUG: omeprazole|DRUG: midazolam|DRUG: rosuvastatin|DRUG: bupropion immediate release (IR)|DRUG: encorafenib|DRUG: binimetinib|DRUG: modafinil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Treosulfan Based Conditioning Regimen and PTCy in HSCT for Nijmegen Breakage Syndrome
Status: RECRUITING
Conditions: Nijmegen Breakage Syndrome
Interventions: DRUG: Treosulfan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TPF-Induction Chemotherapy of Oropharyngeal and Cavity of the Mouth Cancer
Status: COMPLETED
Conditions: Oropharynx Cancer|Squamous Cell Carcinoma of the Oral Cavity
Interventions: DRUG: Taxotere, Cisplatin, 5-Fluorouracil (5-FU)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing Cosopt Switch Patients
Status: COMPLETED
Conditions: Ocular Hypertension|Open-Angle Glaucoma|Exfoliation Syndrome|Glaucoma, Pigmentary
Interventions: DRUG: timolol maleate|DRUG: dorzolamide/timolol maleate fixed combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First in Human Study to Evaluate Safety, Tolerability, Pharmacology of HS-10374 in Healthy Subjects
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: HS-10374 tablets|DRUG: HS-10374-matched placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single-center Randomized Trial for Comparison of Performance Between Domestic and Imported Chemoport
Status: COMPLETED
Conditions: Cancer
Interventions: DEVICE: Celsite chemoport implantation|PROCEDURE: local anesthesia|DEVICE: Humanport chemoport implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Optimal antiPlatelet Therapy for High Bleeding and Ischemic RISK Patients Trial
Status: UNKNOWN
Conditions: Prolonged DAPT in ACS Patients With Hisk of Both Ischemic and Hemorrhage
Interventions: DRUG: Clopidogrel|DRUG: Clopidogrel+aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Complex Intracranial Aneurysm Treatment
Status: UNKNOWN
Conditions: Intracranial Aneurysm
Interventions: PROCEDURE: Endovascular Flow-Diversion|PROCEDURE: Cerebral Revascularization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcome of Glargine Insulin in Renal Impairment Patients With Diabetic Ketoacidosis
Status: UNKNOWN
Conditions: Chronic Kidney Diseases
Interventions: DRUG: Glargine|OTHER: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neurofeedback as a Novel Treatment for Mild Cognitive Impairment & Early Alzheimer's Disease
Status: UNKNOWN
Conditions: Mild Cognitive Impairment|Alzheimer Disease
Interventions: DEVICE: TruScan Neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Ultrasound Guided Fine Needle Biopsy (EUS-FNB-SC) Using a Novel Fork Needle
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DEVICE: Fine Needle Biopsy (FNB)|DEVICE: Fine Needle Aspiration (FNA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Long-term Efficacy and Safety of Aclidinium Bromide/Formoterol Fumarate Fixed-Dose Combination
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Aclidinium Bromide/Formoterol Fumarate|DRUG: Aclidinium Bromide/Formoterol Fumarate|DRUG: Aclidinium Bromide|DRUG: Placebo|DRUG: Formoterol Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AntiCoagulant Effectiveness in Idiopathic Pulmonary Fibrosis
Status: TERMINATED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: warfarin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transauricular Vagal Nerve Stimulation; Functional Dyspepsia and Gastroparesis
Status: NOT_YET_RECRUITING
Conditions: Gastroparesis|Functional Dyspepsia|Healthy|Digestive System Disease|Gastroenterology
Interventions: DEVICE: Transauricular Vagal Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a New Technique to Fill the Defect Generated After Conservative Surgery in Breast Cancer
Status: COMPLETED
Conditions: Breast Conserving Surgery
Interventions: DEVICE: Silicone prosthesis|PROCEDURE: Usual practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maintenance Therapy After Thalidomide-Dexamethasone(ThaDD) for Multiple Myeloma(MM)
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: thalidomide|DRUG: interferon alpha
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Ischemic Preconditioning Combined to Local Ischemic Postconditioning in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: PROCEDURE: Control|PROCEDURE: RIPer|PROCEDURE: RIPer + IPost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Trial of LVGN6051 as Single Agent and in Combination With Keytruda (Pembrolizumab) in Advanced or Metastatic Malignancy
Status: RECRUITING
Conditions: Cancer
Interventions: BIOLOGICAL: LVGN6051|BIOLOGICAL: KEYTRUDA® (pembrolizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Association Between the Effect of Glucocorticoid Pulse Therapy on Neuromyelitis Optica (NMO) and Gene Polymorphism
Status: UNKNOWN
Conditions: Glucocorticoid Resistance|Gene|Neuromyelitis Optica
Interventions: DRUG: Methylprednisolone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p