pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Effect of Exercise on Pharmacodynamics and Pharmacokinetics of a Single Dose of Unfractionated Heparin
Status: COMPLETED
Conditions: Blood Coagulation Disorder
Interventions: DRUG: Unfractionated heparin|BEHAVIORAL: Double-legged cycle ergometer exercise|BEHAVIORAL: Single-legged cycle ergometer exercise, with unfractionated heparin injection in the exercising leg|BEHAVIORAL: Single-legged cycle ergometer exercise, with unfractionated heparin injection in the non-exercising leg|BEHAVIORAL: No exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endostatin in Combination With Oxaliplatin and Radiotherapy in Esophageal Cancer Patients.
Status: UNKNOWN
Conditions: Esophageal Cancer|Endostatin
Interventions: DRUG: Endostatins|DRUG: Oxaliplatin|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-Human Evaluation of GRN-300 in Subjects With Recurrent Ovarian, Primary Peritoneal, and Fallopian Tube Cancers.
Status: SUSPENDED
Conditions: Ovarian Tumors
Interventions: DRUG: GRN-300|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ANRS HB07 IP-Cure-B Proof of Concept (PoC) Clinical Trial. Educating the Liver Immune Environment Through TLR8 Stimulation Followed by NUC Discontinuation
Status: UNKNOWN
Conditions: Hepatitis B, Chronic
Interventions: DRUG: administration of SLGN in arm C|DRUG: Discontinuation of NUC treatment in arms B and C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Using ctDNA Blood Tests to Detect Cancer Cells After Standard Treatment to Trigger Additional Treatment in Early Stage Triple Negative Breast Cancer Patients
Status: UNKNOWN
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Caregivers' Strengths-Skills: Managing Older Cancer Patients' Symptoms
Status: COMPLETED
Conditions: Cancer
Interventions: BEHAVIORAL: FamCare Program|OTHER: Caregiver Support Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy of Air Cleaners in Asthmatics Allergic to Cat in ALYATEC Environmental Exposure Chamber
Status: COMPLETED
Conditions: Asthma|Allergy
Interventions: DEVICE: Active intense Pure Air XL air cleaner|DEVICE: Placebo Intense Pure Air XL air cleaner
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Two Formulations of Proellex for Oral Administration
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Telapristone Acetate, Proellex 12 mg Formulation A|DRUG: Telapristone Acetate, Proellex 12 mg Formulation B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Tumor-Pulsed Dendritic Cells Used as a Tumor Vaccine
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Interleukin-2 (IL-2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Detection of SARS-CoV2 (COVID-19) Between Nasopharyngeal Swab Specimens and Those Obtained by Salivary Sputum
Status: UNKNOWN
Conditions: Covid19
Interventions: DIAGNOSTIC_TEST: Salivary test for COVID19
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Observation Study of T-Gel (1%) in Treatment of Adolescent Boys With Hypogonadism
Status: COMPLETED
Conditions: Primary or Secondary Hypogonadism|Constitutional Delay in Growth and Puberty (CDGP)
Interventions: DRUG: Testosterone Gel (1%)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Zafirlukast Tablets 20 mg of Dr. Reddy's Laboratories Limited Under Fasting Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Zafirlukast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pirfenidone to Prevent Fibrosis in Ards.
Status: RECRUITING
Conditions: Acute Respiratory Distress Syndrome (ARDS)
Interventions: DRUG: Pirfenidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Equity in Smoke-free Housing
Status: ENROLLING_BY_INVITATION
Conditions: Tobacco Use|Tobacco Smoking|Tobacco Use Cessation|Tobacco Use Disorder|Second Hand Tobacco Smoke
Interventions: BEHAVIORAL: Smokefree Implementation Framework and Toolkit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Dexamethasone Treatment for Patients With ARDS Caused by COVID-19
Status: TERMINATED
Conditions: Acute Respiratory Distress Syndrome Caused by COVID-19
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study of ONO-7913, ONO-4538 and the Standard of Care as First-line Treatment in Patients Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Unresectable Advanced or Recurrent Colorectal Cancer
Interventions: DRUG: ONO-7913|DRUG: ONO-4538|DRUG: Fluorouracil|DRUG: Oxaliplatin|DRUG: Levofolinate|DRUG: Bevacizumab|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab And Radiation Therapy Followed by Adjuvant Durvalumab in Patients With Urothelial Cancer (T2-4 N0-2 M0) of the Bladder
Status: UNKNOWN
Conditions: Urothelial Cancer
Interventions: DRUG: durvalumab|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing HAI Plus Chemotherapy and Chemotherapy Alone in Patients With Unresectable CRLM
Status: UNKNOWN
Conditions: Colorectal Adenocarcinoma Metastatic to the Liver
Interventions: DRUG: HAI|DRUG: chemotherapy ± target therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Healthy Adults, Adolescents, Children, and Toddlers in India and Healthy Adolescents and Children in the Republic of South Africa
Status: COMPLETED
Conditions: Healthy Volunteers (Meningococcal Infection)
Interventions: BIOLOGICAL: Meningococcal polysaccharide (serogroups A,C,Y and W) tetanus toxoid conjugate vaccine|BIOLOGICAL: Meningococcal polysaccharide (serogroups A,C,Y and W-135) diphtheria toxoid conjugate vaccine|BIOLOGICAL: Meningococcal polysaccharide (serogroups A, C, Y and W-135) vaccine|BIOLOGICAL: Hepatitis A vaccine|BIOLOGICAL: Measles, Mumps, and Rubella Virus Vaccine (MMR)|BIOLOGICAL: Pneumococcal 13-valent conjugate vaccine|BIOLOGICAL: DTwP-HepB-Hib-IPV vaccine|BIOLOGICAL: Varicella vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ramosetron, Aprepitant and Dexamethasone (RAD) in Solid Cancer
Status: UNKNOWN
Conditions: Solid Tumour|Postoperative Nausea and Vomiting
Interventions: DRUG: Ramosetron, Aprepitant, Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Patient Performance Using the Metoject Device for Subcutaneous Injection in Rheumatoid Arthritis (RA)Patient
Status: COMPLETED
Conditions: Rheumatoid Arthritis (RA)
Interventions: DRUG: Methotrexate (Metoject® prefilled pen)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of LAS41007 in the Treatment of Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: LAS41007 o.d.|DRUG: LAS41007 b.i.d.|DRUG: LAS106521
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Sit to Stand Test in the Decision to Hospitalize a Patient Consulting the Emergency Dept for COVID 19
Status: UNKNOWN
Conditions: SARS-CoV Infection
Interventions: DIAGNOSTIC_TEST: Sit to stand test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: RT, Temozolomide, and Bevacizumab Followed by Bevacizumab/Everolimus in First-line Treatment of GBM
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: RADIATION: Radiation therapy|DRUG: Temozolomide|DRUG: Bevacizumab|DRUG: Bevacizumab|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tralokinumab Monotherapy for Adolescent Subjects With Moderate to Severe Atopic Dermatitis - ECZTRA 6 (ECZema TRAlokinumab Trial no. 6).
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Tralokinumab|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effect of Physical Activity Level on Sleep Quality and Fatigue in Academicians
Status: UNKNOWN
Conditions: Physical Activity|Sleep|Fatigue
Interventions: OTHER: International Physical Activity Questionnaire-Short Form|OTHER: The Pittsburgh Sleep Quality Index|OTHER: The Fatigue Severity Scale|OTHER: General Information Form
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Clemastine Fumarate + Dexamethasone Compared to Dexchlorpheniramine Maleate in Eczema Treatment
Status: COMPLETED
Conditions: Eczema
Interventions: DRUG: Group 1|DRUG: Group 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bridging the Adherence Gap in Internet Interventions: A Randomized Controlled Trial Protocol
Status: NOT_YET_RECRUITING
Conditions: Adherence, Treatment|Job Stress
Interventions: BEHAVIORAL: Adherence self-efficacy-enhancing exercise|BEHAVIORAL: Med-Stress Student
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Paracetamol, Pregabalin and Dexamethasone on Pain and Opioid Requirements in Patients After Hip Operations
Status: COMPLETED
Conditions: Pain|Postoperative
Interventions: DRUG: Pregabalin|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Hypnosis and MEOPA in Regional Painful Syndrome Complex
Status: COMPLETED
Conditions: Algodystrophy of Hand
Interventions: OTHER: Hypnosis, kinesitherapy, MEOPA|OTHER: Usual practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Wearable Devices to Monitor Seizures in Autoimmune Epilepsy
Status: ENROLLING_BY_INVITATION
Conditions: Autoimmune Epilepsy|Healthy
Interventions: DEVICE: Biosensor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Contribution of Immersive Virtual Reality to a Standardized Rehabilitation Program for Upper Limb Chronic Pain: A Single-Case Experimental Design Study
Status: NOT_YET_RECRUITING
Conditions: Complex Regional Pain Syndrome Type I of the Upper Limb
Interventions: DEVICE: H'ability
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Metabolite Identification, Mass Balance, and PK Study of [14C]-Asimadoline to Healthy Adult Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: asimadoline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: S 81694 Plus Paclitaxel in Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer|Metastatic Triple Negative Breast Cancer
Interventions: DRUG: Combination therapy (S81694 + paclitaxel) phase I|DRUG: Paclitaxel|DRUG: Combination therapy (S81694 + paclitaxel) phase II
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Bioequivalence of Sprinkle and Capsule Formulations of Lubiprostone, as Compared to Placebo
Status: COMPLETED
Conditions: Chronic Idiopathic Constipation
Interventions: DRUG: Lubiprostone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Pharmacokinetics of 14C-labeled Isavuconazole Following a Single Oral Dose of 14C-labeled Prodrug Isavuconazonium Sulfate (BAL8557) in Healthy Male Subjects
Status: COMPLETED
Conditions: Pharmacokinetics of 14C-labeled Isavuconazole|Healthy Subjects
Interventions: DRUG: 14C-labeled prodrug isavuconazonium sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Apatinib in Recurrent or Refractory Intracranial Central Nervous System Malignant Tumors
Status: COMPLETED
Conditions: Efficacy and Safety
Interventions: DRUG: apatinib|DRUG: temodar
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy Plus Chemotherapy in Treating Patients With Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: Etoposide|DRUG: Vinblastine|RADIATION: Radiation therapy|DRUG: Cisplatin|RADIATION: Radiation therapy|RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Conventional Antibiotic Strategies Versus Regimens Guided by Epidemiological Surveillance in Infected Patients With Cirrhosis (SURVIC_STUDY)
Status: NOT_YET_RECRUITING
Conditions: Decompensated Cirrhosis|Bacterial Infections
Interventions: OTHER: Conventional antibiotic strategies|OTHER: Regimens guided by epidemiological surveillance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Checkpoint Inhibition (Tremelimumab and/or MEDI4736) in Combination With Radiation Therapy in Patients With Unresectable Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Neoplasms|Pancreatic Cancer|Cancer of Pancreas|Cancer of the Pancreas|Pancreas Cancer
Interventions: BIOLOGICAL: Durvalumab|BIOLOGICAL: Tremelimumab|RADIATION: Sterostatic body radiation therapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Performance Diagnosis of a Patent Foramen Ovale During Lung Transplantation Using Transesophageal Echocardiography
Status: COMPLETED
Conditions: Lung Transplant; Complications
Interventions: DIAGNOSTIC_TEST: search for a patent foramen ovale
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Trial Comparing Laparoscopic Sacropexy and Vaginal Mesh Surgery for Women Cystocele Repair.
Status: COMPLETED
Conditions: Cystocele
Interventions: OTHER: laparoscopic sacrocolpopexy|OTHER: vaginal mesh surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Lung Water by Ultrasound Guided Treatment in Hemodialysis Patients (The Lust Study).
Status: COMPLETED
Conditions: Kidney Failure, Chronic
Interventions: PROCEDURE: Extra-vascular lung water measurements by ultrasound (LW-US)|OTHER: Standard protocol of fluid management in hemodialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spirulina Platensis Supplementation and Calorie Restriction in Obese Men : A Randomized Controlled Trial Protocol Study
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Spirulina supplementation and calorie restriction in obese men
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implant Survival and Peri-abutment Tissue Reactions of Extra-oral Implants.
Status: COMPLETED
Conditions: Maxillofacial Prosthesis Implantation|Extra-oral Implants|Extra-oral Prosthesis|Prostheses and Implants
Interventions: DEVICE: Implantation of BioComp Industries cranio-maxillo-facial (CMF) screw implants
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa
Status: COMPLETED
Conditions: Retinitis Pigmentosa
Interventions: BIOLOGICAL: intravitreal injection of autologous bone marrow stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Latinos CARES (Colorectal Cancer Awareness, Research, Education and Screening)
Status: COMPLETED
Conditions: Colorectal Cancer|Colorectal Carcinoma
Interventions: OTHER: Immunochemical Fecal Occult Blood Test (I-FOBT) Kit|BEHAVIORAL: LATINOS CARES Toolkit|BEHAVIORAL: Standard Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Low Laser Therapy and Hyaluronic Acid as an Adjunct to Non-surgical Periodontal Therapy
Status: RECRUITING
Conditions: Periodontitis
Interventions: DEVICE: SRP+LASER (Dentsply Sirona - SIROLaser Blue)|DEVICE: SRP+HA|DEVICE: SRP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Three Hypoabsortive Surgical Techniques for Treatment of Type IV Morbid Obesity
Status: COMPLETED
Conditions: Bariatric Surgery|Morbid Obesity
Interventions: PROCEDURE: DS vs. SADI-S vs. OAGBP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Is EMG-based Serious Games Effective in Improving Gait in Children With Cerebral Palsy ? Interest of Electromyography Feedback (EMG)
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: DEVICE: Serious Game|OTHER: physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Controlled Study to Assess the Efficacy, Safety and Tolerability of Oral DFD-29 Extended Release Capsules
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: DFD-29 Extended Release Capsules (40 mg)|DRUG: DFD-29 Extended Release Capsules (20 mg)|DRUG: Oraycea® (doxycycline) Capsules|DRUG: Placebo Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluating the Effects of Zoledronic Acid 5 mg Infusion on Bone Mineral Density (BMD) in Postmenopausal Osteoporosis (PMO) Patients Between the Ages of 50 and 65 Years
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis
Interventions: DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Effects of Two Novel Hydration Beverage Formulas on Rehydration in Healthy Adults
Status: COMPLETED
Conditions: Dehydration|Rehydration|Exercise Performance|Exercise Recovery|Fluid Balance|Cognitive Performance
Interventions: OTHER: TP1|OTHER: TP2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Naloxone and Intravenous Methylnaltrexone Effects on Bladder Function
Status: COMPLETED
Conditions: Healthy Males
Interventions: DRUG: Naloxone|DRUG: IV Methylnaltrexone (MNTX)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Abatacept in Patients With Birdshot HLA A29 Uveitis
Status: COMPLETED
Conditions: Eye Diseases|Uveitis
Interventions: DRUG: Abatacept 125 MG/ML Prefilled Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dural Puncture Epidural Technique Versus Conventional Epidural Technique During Vaginal Surgeries
Status: WITHDRAWN
Conditions: Dural Puncture Epidural Technique
Interventions: PROCEDURE: Conventional epidural|PROCEDURE: Dural puncture epidural
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Endostar Combination With Chemotherapy and EGFR-TKI in Lung Cancer Rechallenging Treatment After Acquired Resistance.
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: Recombinant human endostatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine for COVID-19 Post-exposure Prophylaxis (PEP)
Status: COMPLETED
Conditions: COVID-19|Corona Virus Infection|SARS (Severe Acute Respiratory Syndrome)|SARS-CoV-2
Interventions: DRUG: Hydroxychloroquine Sulfate|DRUG: Ascorbic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Eschar Investigations in Scrub Typhus
Status: COMPLETED
Conditions: Scrub Typhus
Interventions: OTHER: Non-invasive eschar samples + blood|OTHER: Non-invasive eschar samples+eschar biopsy+blood|OTHER: Non-invasive eschar samples+eschar biopsy+lymph node fine-needle aspiration biopsy+blood|OTHER: Blood+Skin sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Curcumin on Systemic Lupus Erythematosus
Status: TERMINATED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Curcumin supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Recombinant Norovirus Bivalent (GI. 1 / GII. 4) Vaccine (Hansenula Polymorpha)
Status: UNKNOWN
Conditions: Norovirus Infections|Norwalk Gastroenteritis
Interventions: BIOLOGICAL: middle-dose Norovirus Bivalent (GI.1 / GII.4) Vaccine|BIOLOGICAL: high-dose Norovirus Bivalent (GI.1 / GII.4) Vaccine|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Japan Unified Protocol Clinical Trial for Depressive and Anxiety Disorders (JUNP Study)
Status: COMPLETED
Conditions: Anxiety Disorders|Depressive Disorders
Interventions: BEHAVIORAL: Unified Protocol with Treatment As Usual|OTHER: Treatment As Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Accuracy of Tooth Guided Immediate Implant Placement at Molar Region
Status: COMPLETED
Conditions: Immediate Implant Placement Guided by the Roots of Multiradicular Teeth
Interventions: PROCEDURE: Tooth guided immediate implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Computer-based Patient-reported Data to Assess Long Term and Late Effects of Head and Neck Cancer at the Point-of-care
Status: COMPLETED
Conditions: Head and Neck Cancer Patients|Late Effects
Interventions: BEHAVIORAL: WebCan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chemotherapy Combined With Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: irinotecan hydrochloride|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Macrophage Activation Markers During Sofosbuvir-based Treatment Regimes of Chronic Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Galactose|PROCEDURE: Gastroscopy|PROCEDURE: Liver biopsy|PROCEDURE: Fibroscan|PROCEDURE: Liver vein catheterization|DRUG: Sofosbuvir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Metformin in Children With Motor Deficit
Status: COMPLETED
Conditions: Spina Bifida|Neuromuscular Diseases
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Marginal Evaluation of Zirconia Reinforced Lithium Disilicate Partial Coverage Restoration of Egyptian Posterior Teeth.
Status: ACTIVE_NOT_RECRUITING
Conditions: Carious Teeth|Adaptation
Interventions: OTHER: Zirconia reinforced Lithium disilicate (Vita Ambria) ceramic onlay restoration|OTHER: Lithium disilicate (IPS e-max press) ceramic onlay restoration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 18-Month Study of Memory Effects of Curcumin
Status: COMPLETED
Conditions: Age-associated Cognitive Impairment|Mild Cognitive Impairment (MCI)
Interventions: DRUG: Curcumin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pyrotinib Rechallenge in Her2-positive Metastatic Breast Cancer Pretreated With Pyrotinib and Trastuzumab
Status: RECRUITING
Conditions: HER2-positive Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: Trastuzumab plus chemotherapy|DRUG: Trastuzumab in combination with pyrotinib plus chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EuGeni Rapid Antigen Test for the Qualitative Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Causing COVID19 Disease in Compliance With the World Health Organization (WHO)
Status: TERMINATED
Conditions: SARS-CoV-2 Infection
Interventions: DIAGNOSTIC_TEST: EuGeni SARS-CoV-2 Antigen Rapid Diagnostic Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dasatinib Plus Anti-CD19/CD22 Bispecific CAR-T Cell Therapy for Elderly Ph-positive ALL Patients
Status: RECRUITING
Conditions: Ph Positive ALL|CAR-T Cell|Dasatinib
Interventions: DRUG: Dasatinib plus anti-CD19/CD22 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Motivational Interviewing to Reduce Substance Use Among Depression Patients
Status: COMPLETED
Conditions: Depression|Substance-Related Disorders
Interventions: BEHAVIORAL: Motivational Interviewing|BEHAVIORAL: Control (brochure)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Molsidomine on the Endothelial (Internal Layer of Blood Vessels) Dysfunction in Patients With Angina Pectoris
Status: COMPLETED
Conditions: Stable Angina Pectoris|Atherosclerosis
Interventions: DRUG: Coruno|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality and Post-dry Needling Soreness
Status: COMPLETED
Conditions: Healthy|Epicondylitis of the Elbow
Interventions: OTHER: Real Virtual Reality|OTHER: Placebo Virtual Reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment Of Maxillary Bone Cysts With Autologous Bone Mesenchymal Stem Cells (MSV-H)
Status: COMPLETED
Conditions: Maxillary Cyst|Bone Loss of Substance
Interventions: BIOLOGICAL: MSV treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Colorectal Metastasis Prevention International Trial 2
Status: RECRUITING
Conditions: Colorectal Neoplasms
Interventions: DRUG: Propranolol and etodolac|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Relative Bioavailability Study of Alprazolam 3 mg ER Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Alprazolam 3 mg Extended Release Tablets, single dose|DRUG: XANAX XR® 3 mg tablets, single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Safety & Efficacy Study of Gemcitabine...With High Dose IV Vit. C (HDIVC)
Status: TERMINATED
Conditions: Metastatic Adenocarcinoma of the Pancreas
Interventions: DRUG: Gemcitabine, Intravenous and oral Ascorbic Acid (Vitamin C)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EJV Occlusion Pressure Measurement to Assess Intravascular Volume in Cirrhotic Patients During IV Albumin Substitution
Status: RECRUITING
Conditions: Liver Cirrhosis
Interventions: DEVICE: CPMX2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Tretinoin and Arsenic Trioxide With or Without Gemtuzumab Ozogamicin in Treating Patients With Previously Untreated Acute Promyelocytic Leukemia
Status: RECRUITING
Conditions: Acute Promyelocytic Leukemia With PML-RARA
Interventions: DRUG: Arsenic Trioxide|DRUG: Gemtuzumab Ozogamicin|OTHER: Laboratory Biomarker Analysis|DRUG: Tretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Secondary Prophylaxis After CMV Disease in Kidney Transplant Patients Targeted by γδ T Cells Immunomonitoring.
Status: COMPLETED
Conditions: Kidney Transplant Infection
Interventions: DRUG: Group 1_No proph treatment|DRUG: Group 2A_Proph treatment and γδ T cell expansion|DRUG: Group 2B_Proph treatment and no γδ T cell expansion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Searching for the Optimal tDCS Target Combined With Peripheral Electrical Stimulation in Chronic Low Back Pain
Status: UNKNOWN
Conditions: Chronic Pain|Low Back Pain
Interventions: DEVICE: Transcranial Direct Current Stimulation on M1 and Peripheral Electrical Stimulation|DEVICE: Transcranial Direct Current Stimulation on DLPFC and Peripheral Electrical Stimulation|DEVICE: Sham tDCS and PES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Mobilization With Pegfilgrastim in Lymphoma and Myeloma
Status: COMPLETED
Conditions: Lymphoma|Myeloma
Interventions: DRUG: Injection of Pegfilgrastim|DRUG: Injection of Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-time Motion Management During Prostate and Lung Radiotherapy
Status: ENROLLING_BY_INVITATION
Conditions: Cancer of Lung|Lung Metastasis|Cancer of Prostate
Interventions: RADIATION: Triggered imaging on TrueBeam with margin reduction|RADIATION: Synchrony MLC tracking on fiducials with margin reduction|RADIATION: Synchrony MLC tracking and lung adaptive model with margin reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Single Ascending Doses of IW-3300 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: IW-3300|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Regeneration of Acutely Injured Nerves With Temporary Electrical Stimulation
Status: RECRUITING
Conditions: Nerve Injury
Interventions: DEVICE: Temporary Peripheral Nerve Stimulation System|DEVICE: Sham Temporary Peripheral Nerve Stimulation System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Dental Occlusion Ties
Status: COMPLETED
Conditions: Jaw Fractures|Jaw; Fracture, Upper Jaw|Mandibular Fractures|Maxilla Fracture|Jaw Fixation
Interventions: DEVICE: dental occlusion ties maxillo-mandibular fixation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Iron and Vaccine Response
Status: COMPLETED
Conditions: Iron Deficiency Anemia|Vaccine Preventable Disease|Vaccine Response Impaired|Iron Deficiency Anemia Treatment
Interventions: DIETARY_SUPPLEMENT: Ferinject
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparing the Efficacy of Ultravate Ointment in Combination With Lac-Hydrin Lotion in the Treatment of Psoriasis
Status: COMPLETED
Conditions: Stable Plaque Psoriasis
Interventions: DRUG: Ultravate ointment twice daily + LacHydrin lotion twice daily|DRUG: Ultravate ointment once daily + LacHydrin lotion twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Using Virtual Reality Glasses on Surgical Fear and Anxiety
Status: COMPLETED
Conditions: Open Heart Surgery|Virtual Reality|Preoperative Anxiety|Fear|Nurse
Interventions: OTHER: Experimental (with VR-G)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Alcohol History on Effects of Sevoflurane and Nitrous Oxide - 13
Status: COMPLETED
Conditions: Alcohol-Related Disorders|Opioid-Related Disorders|Substance-Related Disorders
Interventions: DRUG: 30% Nitrous oxide|OTHER: Placebo|DRUG: 0.2% sevoflurane|DRUG: 0.4% sevoflurane|DRUG: 0.6% sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose:
Clinical trial: MRI Assessment of Mode of Action of Bisacodyl, Single Dose
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: Bisacodyl 5 milligram|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Emotion-centered Problem-solving Intervention for Family Caregivers of Stroke Survivors (SoLVE)
Status: NOT_YET_RECRUITING
Conditions: Depression|Stroke
Interventions: BEHAVIORAL: Emotion-centered problem-solving intervention (EPi)|OTHER: stroke education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Pharmacokinetics of CBX129801 in Patients With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes|Diabetes Mellitus|Peripheral Diabetic Neuropathy
Interventions: DRUG: CBX129801|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of Mobile Health Smoking Cessation Approaches Among Underserved Patients in Primary Care
Status: RECRUITING
Conditions: Tobacco Use Cessation
Interventions: BEHAVIORAL: iCanQuit|BEHAVIORAL: iCanQuit+Motiv8|BEHAVIORAL: Florida quit line
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Random Allocation and Allocation by Preference to Mindfulness Practice
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: BEHAVIORAL: Mindfulness of the breath|BEHAVIORAL: Mindfulness of sounds|BEHAVIORAL: Audiobook control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pradaxa or Warfarin for Prevention of Recurrent VTE in Patients With Angiographically Confirmed Acute Massive Pulmonary Embolism undergoIng Endovascular Mechanical Fragmentation and Thrombolytic Therapy
Status: UNKNOWN
Conditions: Angiographically Confirmed Acute Massive Pulmonary Embolism Treated With Endovascular Mechanical Fragmentation and Thrombolytic Therapy
Interventions: DRUG: Dabigatran Etexilate|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral Combination Therapy in a Single Dosage Form in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: metformin/glimepiride combination|DRUG: metformin|DRUG: glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chlorproguanil/Dapsone Compared With Chloroquine and SP for Vivax Malaria
Status: COMPLETED
Conditions: Malaria|Vivax Malaria
Interventions: DRUG: sulfadoxine-pyrimethamine and chlorproguanil-dapsone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Daunorubicin, Cytarabine, and Midostaurin in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Leukemia
Interventions: DRUG: cytarabine|DRUG: daunorubicin|DRUG: midostaurin|OTHER: placebo|DRUG: dexamethasone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Safety and Tolerability of MEDI4736 in Combination With Dabrafenib and Trametinib or With Trametinib Alone
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: Durvalumab|DRUG: Dabrafenib|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Co-administration of Cabergoline and Gliclazide Improve Glycemic Parameters and Lipid Profile in T2DM Patients
Status: UNKNOWN
Conditions: Diabetes
Interventions: DRUG: Cabergoline|DRUG: Gliclazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measurement of Serum Potassium Rate During Accidental Hypothermia.
Status: UNKNOWN
Conditions: Accidental Hypothermia|Hyperkalemia|Cardiac Arrest
Interventions: DIAGNOSTIC_TEST: blood draw from three different vessels
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Denosumab on Cellular Biomarkers in the Human Breast
Status: COMPLETED
Conditions: Healthy Volunteer, Female, Breast
Interventions: DRUG: Denosumab|PROCEDURE: Percutaneous core needle breast biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: My Dose Coach Mobile App to Support Insulin Titration and Maintenance
Status: TERMINATED
Conditions: Diabetes Mellitus Type 2 - Insulin-Treated
Interventions: DEVICE: Smartphone application and web portal|BEHAVIORAL: Standard Insulin Therapy Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison H-FIRE and Laparoscopic RP in Treating Men With Localized Prostate Cancer
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer|Treatment
Interventions: PROCEDURE: Focal therapy(high-frequency irreversible electroporation)|PROCEDURE: laparoscopic radical prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Healing Outcome of Root Canal Therapy in Maxillary Molars With DOM
Status: COMPLETED
Conditions: Periapical Periodontitis
Interventions: PROCEDURE: Nonsurgical Root canal therapy|DEVICE: Dental operating microscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prosocial Behavior and Volunteerism to Promote Physical Activity in Older Adults
Status: COMPLETED
Conditions: Physical Activity
Interventions: BEHAVIORAL: Prosocial Behavior Physical Activity (PBPA)|OTHER: Healthy Aging (HA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Gallium-68 Labeled LM3 PET/CT in Neuroendocrine Tumors
Status: COMPLETED
Conditions: Neuroendocrine Tumors
Interventions: DIAGNOSTIC_TEST: Gallium-68 NODAGA-LM3 PET/CT|DIAGNOSTIC_TEST: Gallium-68 DOTA-LM3 PET/CT|DIAGNOSTIC_TEST: Gallium-68 DOTATATE PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Elucidating the Role of Human Small Intestine Microbiota in Explaining Differences in Postprandial Glucose Responses
Status: COMPLETED
Conditions: Metabolic Syndrome|Obesity|Overweight|Microbiota|Small Intestine|Digestion
Interventions: OTHER: food product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Carboplatin, Bevacizumab and Pemetrexed in the First-Line Treatment of Patients With Malignant Pleural Mesothelioma (MPM)
Status: TERMINATED
Conditions: Mesothelioma
Interventions: DRUG: Carboplatin, Bevacizumab and Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Long-term Safety and Efficacy of Erenumab (AMG 334) in Chronic Migraine Prevention.
Status: COMPLETED
Conditions: Treatment for Prevention of Chronic Migraine
Interventions: DRUG: Erenumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Emblica Officinalis Irrigation in Periodontitis
Status: COMPLETED
Conditions: Periodontitis
Interventions: PROCEDURE: SRP+ 10% Emblica officinalis irrigation|PROCEDURE: SRP + 0.2% Chlorhexidine irrigation)|PROCEDURE: SRP + 0.9% Saline irrigation|PROCEDURE: SRP +10% E. officinalis gel application.|PROCEDURE: SRP+ placebo gel application.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radial Extracorporeal Shock Wave Therapy for Chronic Soft Tissue Wounds
Status: UNKNOWN
Conditions: Wound of Skin
Interventions: DEVICE: rESWT|DEVICE: Sham rESWT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Open-Label Study of Daclatasvir and Sofosbuvir With or Without Ribavirin for 8 Weeks in Treatment-Naïve, Non-cirrhotic Subjects Infected With Chronic Hepatitis C Virus (HCV) Genotype 3
Status: WITHDRAWN
Conditions: Hepatitis C
Interventions: DRUG: Daclatasvir|DRUG: Sofosbuvir|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of HS135 for the Treatment of Pulmonary Arterial Hypertension in Adults
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Arterial Hypertension (PAH)
Interventions: BIOLOGICAL: HS135
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT