pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Phase II Clinical Trial of Chemotherapy With or Without Endostar® Continuous Intravenous Infusion in Refractory NPC
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Recombinant Human Endostatin Injection (Endostar)|DRUG: Fluorouracil (5-Fu)|DRUG: Nedaplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caloric Restriction in Treating Patients With Stage 0-I Breast Cancer Undergoing Surgery and Radiation Therapy
Status: COMPLETED
Conditions: Ductal Breast Carcinoma in Situ|Invasive Ductal Breast Carcinoma|Invasive Lobular Breast Carcinoma|Lobular Breast Carcinoma in Situ|Recurrent Breast Cancer|Stage IA Breast Cancer|Stage IB Breast Cancer
Interventions: BEHAVIORAL: Behavioral dietary intervention|PROCEDURE: Therapeutic conventional surgery|RADIATION: Radiation therapy|OTHER: Counseling intervention|PROCEDURE: Quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Open Study of the Effect of Itraconazole Oral Solution for the Treatment of Fluconazole Refractory Oropharyngeal Candidiasis in HIV-Positive Subjects.
Status: COMPLETED
Conditions: Candidiasis, Oral|HIV Infections
Interventions: DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Lignocaine as an Analgesic Adjunct in Adolescent Idiopathic Scoliosis Surgery
Status: COMPLETED
Conditions: Adolescent Idiopathic Scoliosis|Analgesia
Interventions: DRUG: Lignocaine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inappropriate Prescription in Elderly and Polypharmacy Patients in Primary Care (PHARM-PC) Trial
Status: COMPLETED
Conditions: Elderly (People Aged 65 or More)|Polypharmacy (People Under Treatment With 5 or More Drugs)
Interventions: BEHAVIORAL: Pharmacist intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Safety of and Immune Response to a Dengue Vaccine (TV003) in Healthy Adults, Adolescents, and Children in Thailand
Status: COMPLETED
Conditions: Dengue
Interventions: BIOLOGICAL: TV003|BIOLOGICAL: Placebo for TV003
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Beetroot Juice on Coronary Blood Flow and Walking Performance in PAD
Status: ACTIVE_NOT_RECRUITING
Conditions: Peripheral Arterial Disease
Interventions: DRUG: Beetroot juice|DRUG: Beetroot juice placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of TKIs' Withdrawal After a Two-step Dose Reduction in Patients With Chronic Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Myeloid Leukemia, Chronic Phase|Withdrawal;Drug
Interventions: DRUG: Imatinib withdrawal|DRUG: Dasatinib|DRUG: Nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Total Endovascular Aortic Arch Re-construction Study(TEARS)
Status: UNKNOWN
Conditions: Aorta Dissection|Aorta Aneurysm
Interventions: DEVICE: Ankura Branched/Fenestrated Stent Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Superficial Cervical Plexus Block and Nerve of Arnold Block and Incidence of PONV for Inner Ear Surgery
Status: TERMINATED
Conditions: Anesthesia, Pediatrics, Surgery
Interventions: PROCEDURE: regional nerve block|DRUG: Antiemetic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Cabozantinib S-malate in Treating Patients With Metastatic Pheochromocytomas or Paragangliomas That Cannot Be Removed by Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Paraganglioma|Metastatic Adrenal Gland Pheochromocytoma|Metastatic Paraganglioma|Regional Adrenal Gland Pheochromocytoma|Unresectable Adrenal Gland Pheochromocytoma|Unresectable Paraganglioma
Interventions: DRUG: Cabozantinib S-malate|OTHER: Laboratory Biomarker Analysis|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Bioactive Enriched Food on Markers of Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Ready-made pancakes enriched with docosahexaenoic acid (DHA)|DIETARY_SUPPLEMENT: Ready-made pancakes enriched with beta-glucan (BG)|DIETARY_SUPPLEMENT: Ready-made pancakes enriched with anthocyanins (AC)|DIETARY_SUPPLEMENT: Ready-made pancakes enriched with docosahexaenoic acid and beta-glucan (DHA+BG)|DIETARY_SUPPLEMENT: Ready-made pancakes enriched with docosahexaenoic acid and anthocyanins (DHA+AC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) In The Treatment Of Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Desvenlafaxine Succinate Sustained-Release (DVS SR)|DRUG: Desvenlafaxine Succinate Sustained-Release (DVS SR)|DRUG: Placebo|DRUG: Duloxetine 60 mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Variation in the Effect of Dexamethasone Associated With Axillary Plexus on the Occurrence of Rebound Pain
Status: NOT_YET_RECRUITING
Conditions: Adjuvants, Anesthesia|Brachial Plexus Anesthesia
Interventions: OTHER: upper extremity bone surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The ECEALT Chronic Low Back Pain Study
Status: UNKNOWN
Conditions: Chronic Low-back Pain
Interventions: DEVICE: BTL 4110 Smart Laser Therapy Equipment (BTL Industries Ltd, United Kingdom (UK))|OTHER: Standard Exercise Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the TheraNova Neuromodulation System to Provide Durable Relief of Overactive Bladder Symptoms
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DEVICE: TheraNova Neuromodulation Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Uterine Closure Techniques on the Cesarean Scar Thickness After Repeated Cesarean Section
Status: UNKNOWN
Conditions: Cesarean Section, Repeated|Cesarean, Uterine Scar Thickness|Cesarean, Residual Myometrial Thickness|Cesarean Section Complications|Cesarean Section; Complications, Wound, Dehiscence
Interventions: PROCEDURE: Single layer closure|PROCEDURE: Double layer closure after resection uterine scar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protocols for Painless Photodynamic Therapy (PDT) of Actinic Keratoses
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: PROCEDURE: Aminolevulinic acid based photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Suture Versus Mesh Rectopexy for the Treatment of Persistent Complete Rectal Prolapse in Children
Status: COMPLETED
Conditions: Rectal Prolapse
Interventions: DEVICE: Laparoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Functional Training for the Prevention of Deep Venous Thrombosis
Status: UNKNOWN
Conditions: Ankle Motion|Gynecologic Neoplasm|Deep Venous Thrombosis|Abdominal Breathing
Interventions: BEHAVIORAL: passive ankle pump motions on the day of surgery|BEHAVIORAL: active ankle pump motions and abdominal breathing training on the 1-3 day after the surgery|COMBINATION_PRODUCT: Regular care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Adding Folic Acid on Lipid Parameters in Population With Dyslipidemias
Status: UNKNOWN
Conditions: Dyslipidemias
Interventions: DIETARY_SUPPLEMENT: Folic Acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: DB RCT for Specialized Phototherapy in Parkinson's Disease.
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: Celeste Specialized Phototherapy Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The RCT of Acupuncture on PCOS Combined With IR
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Insulin Resistance
Interventions: OTHER: true acupuncture|OTHER: sham acupuncture|DRUG: metformin|DRUG: Placebo metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Nivolumab +/- Nab-paclitaxel in Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-Small-Cell Lung Cancer Metastatic|Non-Small Cell Carcinoma of Lung, TNM Stage 4|Nonsmall Cell Lung Cancer|Non Small Cell Lung Cancer Recurrent
Interventions: DRUG: Nivolumab|DRUG: nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Efficacy of Guselkumab to Fumaric Acid Esters for the Treatment of Participants With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Guselkumab|DRUG: Fumaric Acid Esters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Pain and Disability After Breast Cancer Surgery
Status: COMPLETED
Conditions: Breast Cancer|Chronic Pain
Interventions: PROCEDURE: Thoracic Paravertebral Block (TPVB)|PROCEDURE: Local Anesthetic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Urothelial Cancer Screening in Individuals With Lynch Syndrome Using a Urine Tumor DNA Panel (LS-URO Study)
Status: RECRUITING
Conditions: Urothelial Carcinoma|Lynch Syndrome
Interventions: DIAGNOSTIC_TEST: Urothelial cancer screening using urine tumor DNA test|DIAGNOSTIC_TEST: Urothelial cancer screening using urine cytology (comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Evaluation of PD-L1 (Programmed Death-Ligand 1) Tumor Expression in Patients With Large-cell Neuroendocrine Carcinoma (NEC)
Status: COMPLETED
Conditions: Large Cell Lung Cancer|Neuroendocrine Carcinoma of Lung (Diagnosis)
Interventions: OTHER: Immunohistochemistry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Simultaneous Fluorodeoxyglucose Positron Emission Tomography (PET) and Magnetic Resonance (MR) in Visual Snow Syndrome
Status: COMPLETED
Conditions: Visual Snow Syndrome
Interventions: DIAGNOSTIC_TEST: simultaneous fluor-18 fluorodeoxyglucose (FDG) positron emission tomography with magnetic resonance imaging (PET/MRI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Multi-Center Trial to Determine the Safety and Efficacy of LX1033 in Subjects With Diarrhea-Predominant Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: 250 mg LX1033 tablets|DRUG: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-flow Nasal Cannula Oxygenation Decrease Hypoxia in Gastroscopy Sedated by Propofol
Status: COMPLETED
Conditions: Hypoxia|Gastric Cancer|Esophagus Cancer|Adverse Event
Interventions: DEVICE: High-flow nasal cannula oxygenation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: RITUAL Ultivision AI CADe Randomized Controlled Trial
Status: TERMINATED
Conditions: Colon Adenoma|Polyp of Colon|Adenoma Colon
Interventions: DEVICE: Ultivision AI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Advanced Benefits of Alpha-blocker Monotherapy on Lower Urinary Tracts Symptoms(LUTS) Patients
Status: UNKNOWN
Conditions: Benign Prostate Hyperplasia
Interventions: DRUG: Tamsulosin|DRUG: Finasteride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-SEAL™IT: Saccular Endovascular Aneurysm Lattice System First In Human Interventional Trial
Status: COMPLETED
Conditions: Aneurysms Saccular|Aneurysm, Ruptured|Aneurysm
Interventions: DEVICE: SEAL Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caregiver Protocol for Remotely Improving, Monitoring, and Extending Quality of Life
Status: COMPLETED
Conditions: Stress|Quality of Life|Sleep Disturbance
Interventions: OTHER: Remote health coaching to improve self-care behaviors
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of the Gastric Reactance (XL) in Patients Post-operated of Elective Cardiac Surgery
Status: COMPLETED
Conditions: Cardiac Failure|Ventricular Dysfunction|Valvular Heart Disease
Interventions: DEVICE: Florence device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: EXPAREL® for Pain After Tonsillectomy
Status: COMPLETED
Conditions: Tonsillectomy|Tonsillitis|Post-operative Pain
Interventions: DRUG: Liposomal Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Interim FDG PET/CT in Diffuse Large B Cell Lymphoma (DLBCL) Patients
Status: UNKNOWN
Conditions: Lymphoma, Large B-Cell, Diffuse
Interventions: OTHER: Early interim FDG PET/CT after 1 cycle of R-CHOP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety of Juvista When Administered Following Excision of Ear Lobe Keloids
Status: COMPLETED
Conditions: Keloid
Interventions: DRUG: Avotermin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Metastatic Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Metastatic Breast Cancer|Metastatic Gastrointestinal Carcinoma|HER2-positive Breast Cancer|HER2-positive Gastric Cancer|EGFR Overexpression
Interventions: BIOLOGICAL: Combination of MVF-HER-2 (597-626) and MVF-HER-2 (266-296) emulsified with ISA 720
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: School Inner City Air Study
Status: NOT_YET_RECRUITING
Conditions: Viral Infection
Interventions: OTHER: Active classroom HEPA cleaner|OTHER: Sham classroom HEPA cleaner
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Prenatal Yoga-Assisted Birth Preparation Training on Fear of Childbirth and Childbirth Self-Efficacy
Status: NOT_YET_RECRUITING
Conditions: Fear of Childbirth|Childbirth Self Efficacy
Interventions: OTHER: Birth preparation training|OTHER: Prenatal yoga practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: "Safety, Tolerability and Pharmacokinetics of MP-376 Administered for 14 Days to Stable Pediatric (CF) Patients"
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: MP-376 (Levofloxacin solution for Inhalation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ERP Plus Improv Group Therapy for OCD (IMPROVE Study)
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: OTHER: Group Improv sessions|BEHAVIORAL: Group Exposure and Response Prevention (ERP) Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CTX-009 (ABL001) in Combination With Irinotecan or Paclitaxel in Advanced or Metastatic Solid Tumor Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: P1b: Advanced Solid Tumors|P2: Biliary Tract Cancer
Interventions: DRUG: CTX-009 (ABL001)|DRUG: Paclitaxel|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy of Adebrelimab Combined With Chemotherapy After HIFU Induction Neoadjuvant Therapy HR+/HER2- Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|HR+/HER2- Breast Cancer
Interventions: DRUG: Adebrelimab|PROCEDURE: High Intensity Focused Ultrasoun（HIFU）|DRUG: Cyclophosphamide|DRUG: Epirubicin|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of Avelumab In Combination With Axitinib In Advanced HCC (VEGF Liver 100)
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Avelumab (MSB0010718C)|DRUG: Axitinib (AG-013736)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donation of Whole Blood by Healthy Volunteers After Mobilisation by Haematopoietic Growth Factor (Rhu-G-CSF = Granocyte)
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: Lenograstim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Intervention With Omega Fatty Acids in High-risk Patients
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: Omega-3 Fatty Acid|DIETARY_SUPPLEMENT: Omega-6 Fatty Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Open-label Study of Vedolizumab (MLN0002) in Participants With Ulcerative Colitis and Crohn's Disease
Status: COMPLETED
Conditions: Ulcerative Colitis|Crohn's Disease
Interventions: DRUG: Vedolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Rotavirus Efficacy and Safety Trial (REST)(V260-006)
Status: COMPLETED
Conditions: Rotavirus Infections
Interventions: BIOLOGICAL: Rotateq™|BIOLOGICAL: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety Study of Individual Paclitaxel Dose Adjustment Based on Pharmacokinetics in Non-Small Cell Lung Cancer (NSCLC)
Status: UNKNOWN
Conditions: Non-Small Cell Lung Cancer
Interventions: OTHER: dosage of paclitaxel|OTHER: dosage of paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testosterone Treatment for Erectile Dysfunction and Multiple Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis|Erectile Dysfunction|Testosterone Deficiency
Interventions: DRUG: XYOSTED 75 milligram (mg) in 0.5 ML Auto-Injector
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concordance Between the Systolic Foot-to-Apex Interval and the Auscultatory Method for Measuring Brachial Systolic Pressure in Pregnant Women With or Without Blood Pressure Disorders and Search for Markers of Arterial Stiffness in Pre-eclampsia.
Status: COMPLETED
Conditions: Blood Pressure Disorders|Pregnancy Induced Hypertension
Interventions: DEVICE: Blood pressure measurement and collection of the oscillometric curve for later SFATI analysis|DEVICE: Blood pressure measurement with the usual equipment used in the department|DEVICE: systematic measurement of pulse wave velocity (aortic and brachial)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Train Your Brain: Neurofeedback Intervention for PTSD
Status: TERMINATED
Conditions: Stress Disorders, Post-Traumatic
Interventions: DEVICE: eBrainFit Platform|DEVICE: eBrainFit Platform
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Civamide Patch Safety, Tolerability and PK Study
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Zucapsaicin|DRUG: Zucapsaicin|DRUG: Placebo patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mini-invasive Spine Surgery for Neuromuscolar Scoliosis
Status: NOT_YET_RECRUITING
Conditions: Neuromuscular Scoliosis|Spine Deformity|Surgery|Vertebral Fusion
Interventions: PROCEDURE: mini-invasive spine surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Utility of Ultrasound Guided iPACK Block for Knee Extension After Total Knee Arthroplasty.
Status: COMPLETED
Conditions: Knee Osteoarthritis|Primary Total Knee Arthroplasty|Physical Therapy|Pain|Knee Extension
Interventions: DRUG: Ropivacaine|PROCEDURE: Interspace Between the Popliteal Artery and Capsule of the Knee (iPACK) Block|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Using a Telemedicine Approach in a Genome-wide Association Study of Atopic Dermatitis - Searching for Novel Biomarkers in Clinically Relevant Phenotypes
Status: WITHDRAWN
Conditions: Atopic Dermatitis|Eczema|DNA
Interventions: BEHAVIORAL: DNA reports|BEHAVIORAL: Information reports
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Cognitive Enhancing Effects of D-Cycloserine Among Non-Demented Elderly
Status: COMPLETED
Conditions: Treatment|Placebo
Interventions: DRUG: d-cycloserine|DRUG: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of BARS13 in the Elderly
Status: ACTIVE_NOT_RECRUITING
Conditions: Respiratory Syncytial Virus Infections
Interventions: DRUG: Recombinant Respiratory Syncytial Virus Vaccine (BARS13) /placebo|DRUG: Recombinant Respiratory Syncytial Virus Vaccine (BARS13)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: the Role of Popliteal Plexus Block in Pain Management After Anterior Cruciate Ligament Reconstruction.
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: PROCEDURE: saphenous nerve block|PROCEDURE: popliteal plexus block|DRUG: Plain bupivacaine|DRUG: 0.05 mg epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Eschscholtzia Californica in Treating Primary Insomnia
Status: TERMINATED
Conditions: Sleep Initiation and Maintenance Disorders
Interventions: DRUG: Eschscholtzia Californica|DRUG: Eschscholtzia Californica Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: REDUCE LAP-HF TRIAL II
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure
Interventions: DEVICE: IASD System II implant|OTHER: intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of High Flow Nasal Cannula on Oxygenation During Urodynamic Study in Pediatric Population
Status: UNKNOWN
Conditions: Desaturation
Interventions: DEVICE: High flow nasal cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Long-term Metabolic Effects of Cafestol
Status: UNKNOWN
Conditions: Obesity, Abdominal
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Cafestol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prevention of Diarrhea in Patients Taking IV Irinotecan for Relapsed or Difficult to Treat Pediatric Solid Tumors
Status: COMPLETED
Conditions: Neoplasm|Diarrhea
Interventions: DRUG: Irinotecan, Cefpodoxime
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock
Status: RECRUITING
Conditions: Septic Shock
Interventions: DRUG: Stress-dose Hydrocortisone plus Vitamin C|DRUG: isotonic sodium chloride solution placebo plus isotonic sodium chloride solution placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Monitor Subcutaneous Human Immunoglobulin Administered at Modified Dosing Regimens in Patients With Primary Immunodeficiency Diseases
Status: COMPLETED
Conditions: Primary Immune Deficiency Disorder
Interventions: DRUG: CUTAQUIG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab-pkrb Combined With Modified FOLFOX-6 in Biliary Tract Cancer Patients Progressed on First Line Therapy
Status: COMPLETED
Conditions: HER2 Positive Advanced/Metastatic/Nonresectable Biliary Tract Cancer
Interventions: DRUG: HERZUMA+mFOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Pilot Clinical Study of PG2 Injection on Hemorrhagic Stroke
Status: COMPLETED
Conditions: Hemorrhagic Stroke
Interventions: DRUG: PG2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Patients With Different Types of Advanced Cancer (Solid Tumors) to Test Different Doses of BI 907828 (Brigimadlin) in Combination With BI 754091 (Ezabenlimab) and BI 754111 or BI 907828 (Brigimadlin) in Combination With BI 754091 (Ezabenlimab)
Status: ACTIVE_NOT_RECRUITING
Conditions: Neoplasms
Interventions: DRUG: BI 907828|DRUG: ezabenlimab|DRUG: BI 754111
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep and Circadian Mechanisms in Hypertension
Status: RECRUITING
Conditions: Hypertension|Cardiovascular Diseases|Cardiovascular Risk Factors|Circadian Rhythms|Sleep
Interventions: OTHER: At-home Polysomnography|OTHER: Circadian Protocol|OTHER: Rested Wakefulness Trial|OTHER: Overnight Sleep Trial|BEHAVIORAL: Regularized Sleep Schedule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neuropsychological Rehabilitation Over the Internet
Status: RECRUITING
Conditions: Stroke, Acute Ischemic|Brain Hemorrhage|Encephalitis|Hypoxia-Ischemia, Brain|Traumatic Brain Injury
Interventions: BEHAVIORAL: Digital care pathway|BEHAVIORAL: Care as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: PF-04449913 For Patients With Acute Myeloid Leukemia at High Risk of Relapse After Donor Stem Cell Transplant
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia in Remission|Recurrent Adult Acute Myeloid Leukemia
Interventions: DRUG: PF-04449913
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analysis of Vestibular Compensation Following Clinical Intervention for Vestibular Schwannoma
Status: ENROLLING_BY_INVITATION
Conditions: Migraine|Vestibular Migraine|Vestibular Schwannoma|Motion Sickness|Dizziness|Vestibular Disorder
Interventions: BEHAVIORAL: Temporal Binding Adaptation - TBW training|BEHAVIORAL: Temporal Binding Adaptation - PSS training|BEHAVIORAL: Temporal Binding Adaptation - PSS adaptation with VI stimulation|BEHAVIORAL: Chronic Motion-modulated Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Clinical Trial to Evaluate the Regenerative Capacity of CardioCell in Patients With Chronic Ischaemic Heart Failure (CIHF)
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: CardioCell|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Progenitor Potential of Mesenchymal Stem Cells in Palatal Tissue Harvested From Molar and Premolar Sites
Status: ACTIVE_NOT_RECRUITING
Conditions: Gingival Recession|Lack of Keratinized Gingiva (Disorder)
Interventions: DIAGNOSTIC_TEST: progenitor potential of Gingival Mesenchymal cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Pancreatic Duct Stenting in Acute Necrotizing Pancreatitis
Status: UNKNOWN
Conditions: Acute Necrotizing Pancreatitis
Interventions: PROCEDURE: ERCP and pancreatic stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of INERSAN in Patients With Chronic Periodontitis as Adjunctive to Full Mouth Disinfection
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: DIETARY_SUPPLEMENT: lactobacillus brevis tablets|DIETARY_SUPPLEMENT: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy Study for the Symptomatic Treatment of Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: bilastine|DRUG: Cetirizine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Acute Energy Deficit and Aerobic Exercise on Muscle Quality
Status: COMPLETED
Conditions: Energy Supply; Deficiency|Energy Balance|Energy Availability
Interventions: DIETARY_SUPPLEMENT: Energy Balance|DIETARY_SUPPLEMENT: Energy Deficit|DIETARY_SUPPLEMENT: Baseline Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Post-operative Pain Reduction
Status: UNKNOWN
Conditions: Effects of the Elements
Interventions: DRUG: Conventional calcium hydroxide paste|DRUG: Calcium hydroxide nanoparticle|DRUG: Combined Calcium hydroxide with silver nanoparticle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nursing Care Interventions According to Integrative Nursing and Omaha System in Elderly Women Feeling Loneliness
Status: COMPLETED
Conditions: Loneliness
Interventions: BEHAVIORAL: Group-based interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Feasibility, Safety and QoL After Merendino Procedure
Status: COMPLETED
Conditions: Benign or Early Malignant Lesion of the Distal Esophagus or Gastro-esophageal Junction Requiring Surgical Resection
Interventions: OTHER: EORTC and QLQ-C30 / QLQ-OES24 questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of JMKX003142 Injection in Chinese Healthy Subjects
Status: NOT_YET_RECRUITING
Conditions: Healthy Adult
Interventions: DRUG: JMKX003142 Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Pulmonary Telerehabilitation and Physical Activity Recommendations in Patients With Post Covid Fibrosis
Status: RECRUITING
Conditions: COVID-19|Pulmonary Fibrosis
Interventions: OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Antibiotic Prophylaxis of Infective Endocarditis for Invasive Dental Procedures in Patients With Prosthetic Heart Valves and/or History of Infective Endocarditis
Status: NOT_YET_RECRUITING
Conditions: Endocarditis, Bacterial|Endocarditis|Endocarditis Acute and Subacute
Interventions: OTHER: Improved practices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Health Effects of Milk Proteins in Elderly Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Milk|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development and Evaluation of an Online Multidimensional Musculoskeletal Health Programme
Status: UNKNOWN
Conditions: Occupational Health
Interventions: OTHER: 4 weekly musculoskeletal health promotion workshops with stretching and muscle-strengthening exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity Study of Antibody Persistence and Booster Effect of DTaP-HB-PRP~T Combined Vaccine or Tritanrix-HepB/Hib™
Status: COMPLETED
Conditions: Diphtheria|Tetanus|Pertussis|Hepatitis B|Haemophilus Influenzae Type b
Interventions: BIOLOGICAL: DTaP-HB-PRP~T vaccine|BIOLOGICAL: Tritanrix-HepB/Hib™|BIOLOGICAL: Oral Polio Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Regional Block for Upper Abdominal Surgeries
Status: NOT_YET_RECRUITING
Conditions: Perioperative Analgesia in Major Upper Abdominal Surgery
Interventions: PROCEDURE: Block group|PROCEDURE: Morphine infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel-Coated Versus Uncoated Balloon for Treatment of Below-the-Knee In-Stent-Restenosis
Status: WITHDRAWN
Conditions: In-stent Stenosis of Infrapopliteal Arteries
Interventions: DEVICE: paclitaxel-coated balloon|DEVICE: non-coated balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial
Status: RECRUITING
Conditions: Degenerative Mitral Valve Disease|Mitral Regurgitation|Mitral Insufficiency|Functional Mitral Regurgitation
Interventions: DEVICE: Edwards PASCAL System|DEVICE: Abbott Mitraclip System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MTD, Safety, and Efficacy of Pomalidomide (CC-4047) Alone or With Low-dose Dexamethasone in Patients With Relapsed and Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Pomalidomide|DRUG: Dexamethasone|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Rituximab For the Treatment of Calcineurin Inhibitors Dependent Nephrotic Syndrome During Childhood
Status: COMPLETED
Conditions: Childhood Idiopathic Nephrotic Syndrome
Interventions: DRUG: Rituximab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid Infusion in Low Dose Versus in High Dose for Reducing Blood Loss in Radical Cystectomy Operations
Status: UNKNOWN
Conditions: Bleeding
Interventions: DRUG: Tranexamic acid|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effects of Minimal and High Flow Anesthesia on Thiol Disulfide Balance and StO2 in Hypotensive Anesthesia Applications
Status: UNKNOWN
Conditions: Oxidative Stress
Interventions: OTHER: Minimal Flow Anesthesia|OTHER: High Flow Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Adolescent Outpatient and Continuing Care Study
Status: COMPLETED
Conditions: Substance Abuse|Substance Dependence
Interventions: BEHAVIORAL: Chestnut Bloomington Outpatient (CBOP)|BEHAVIORAL: Motivational Enhancement Therapy/Cognitive Behavior Treatment (MET/CBT 7)|BEHAVIORAL: Assertive Continuing Care (ACC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis
Status: NOT_YET_RECRUITING
Conditions: Familial Adenomatous Polyposis
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: EP2/EP4 Antagonist TPST-1495|PROCEDURE: Esophagogastroduodenoscopy|PROCEDURE: Gastrointestinal Endoscopy|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sedation Complications in Urology During Spinal Anesthesia With Dexmedetomidine or Midazolam Regarding OSA Risk
Status: COMPLETED
Conditions: Anesthesia|Anesthesia Complication|Osa Syndrome|Transurethral Resection of Prostate|Sedation Complication|Intraoperative Complications|Snoring|Airway Obstruction
Interventions: PROCEDURE: Spinal anesthesia with intraoperative dexmedetomidine sedation|PROCEDURE: Spinal anesthesia with intraoperative midazolam sedation|DRUG: Dexmedetomidine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Theory Based SMS Reminders - Text's Impact on Patient Attendance
Status: UNKNOWN
Conditions: Otorhinolaryngologic Diseases|Sleep Disorders|Hearing Disorders
Interventions: OTHER: Emotional SMS text|OTHER: Standard SMS text
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Trial of BI 765063 Monotherapy and in Combination With BI 754091 in Patients With Advanced Solid Tumours
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor, Adult
Interventions: DRUG: BI 765063|DRUG: BI 754091
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MTA vs CEM Pulpotomy in Young Permanent Molars
Status: UNKNOWN
Conditions: Irreversible Pulpitis
Interventions: OTHER: CEM and MTA|OTHER: MTA and CEM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Surface EMG Biofeedback as an Alternative Therapy to Reduce Chronic Low Back Pain
Status: RECRUITING
Conditions: Chronic Low Back Pain
Interventions: OTHER: Surface Electromyography (sEMG) Biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Testosterone Gel to Restore Normal Serum Values of Testosterone During the Acute Phase of Critical Illness in Adult ICU Patients
Status: RECRUITING
Conditions: Hypermetabolism in ICU|Loss of Muscle Mass|Functional Disability After ICU|ICU Acquired Hypogonadism|Treatment With Testosterone Gel in ICU
Interventions: DRUG: AndroGel 16.2 mg/L
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Treatment of Tuberculosis in HIV-Infected Patients
Status: COMPLETED
Conditions: HIV Infections|Tuberculosis
Interventions: DRUG: Ethambutol hydrochloride|DRUG: Isoniazid|DRUG: Pyrazinamide|DRUG: Pyridoxine hydrochloride|DRUG: Levofloxacin|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Nivolumab in Combination With Talazoparib in Melanoma and Mutations in BRCA or BRCA-ness Genes
Status: COMPLETED
Conditions: Metastatic or Unresectable Melanoma
Interventions: DRUG: Nivolumab|DRUG: Talazoparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bosutinib Treatment Extension Study Only For Subjects With Chronic Myeloid Leukemia (CML) Who Have Previously Participated In Bosutinib Studies B1871006 Or B1871008
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: bosutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Increasing Pre-Surgical Identification of Muscle Invasive Tumor Evaluations Prior to Planned Cystectomy (INSITE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Urothelial Carcinoma|Muscle Invasive Bladder Urothelial Carcinoma|Non-Muscle Invasive Bladder Urothelial Carcinoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dacomitinib for Treatment of Patients in India With Metastatic Non Small Cell Lung Cancer With EGFR Activating Mutations
Status: COMPLETED
Conditions: Metastatic Non Small Cell Lung Cancer
Interventions: DRUG: Dacomitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Tuvusertib (M1774) in Combination With DNA Damage Response Inhibitor or Immune Checkpoint Inhibitor (DDRiver Solid Tumors 320)
Status: RECRUITING
Conditions: Metastatic or Locally Advanced Unresectable Solid Tumors
Interventions: DRUG: Tuvusertib|DRUG: Lartesertib|DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Optimal Urethral Coverage in Hypospadias Repair: Dartos Fascia Versus Tunica Vaginalis Flap? A Randomized Controlled Trial
Status: UNKNOWN
Conditions: Pediatric Disorder|Hypospadias|Congenital Hypospadia|Urologic Diseases
Interventions: PROCEDURE: Hypospadias repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Colic With the Probiotic Lactobacillus Reuteri
Status: UNKNOWN
Conditions: Colic
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri DSM 17938|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Tolerability and Safety of Two New Doses of Grass MATA MPL
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: BIOLOGICAL: Grass MATA MPL 10200|BIOLOGICAL: Grass MATA MPL 18200|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT