pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Recovery Kinetics After Different Power Training Protocols (PTRecovery)
Status: COMPLETED
Conditions: Core Exercises Training|Structural Exercises Training|Accentuated Eccentric Exercises Training|Control Condition
Interventions: OTHER: Core exercises training|OTHER: Structural exercises training|OTHER: Accentuated eccentric exercises training|OTHER: Control trial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A New Hormone Replacement Paradigm: Physiologic Restoration Study
Status: UNKNOWN
Conditions: Menopause|Perimenopausal Disorder|Menopause Related Conditions
Interventions: BIOLOGICAL: Compounded topical estradiol and compounded topical progesterone in a carrier cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sterile Wound Care Liquid Dressing in Treatment of Diabetic Ulcer in Necrosis Stable Stage: a Randomized Control Trial
Status: NOT_YET_RECRUITING
Conditions: Diabetic Ulcers|Diabetic Ulcers in Necrosis Stable Stage
Interventions: DEVICE: Sterile Wound Care Liquid Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Investigation of the Use of Drive App to Measure Sleep Parameters in Users of CPAP Therapy
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea
Interventions: OTHER: Drive app|DEVICE: Non contact motion sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effects Of Walnut-Enriched Diet On Blood Lipids And Glucose Profiles In Hyperlipidemic Subjects
Status: COMPLETED
Conditions: Hyperlipidemias
Interventions: DIETARY_SUPPLEMENT: Walnut-enriched Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of High-dose Folic Acid Supplementation on Pathways Linked to DNA Formation
Status: NOT_YET_RECRUITING
Conditions: One-carbon Metabolism in Healthy Individuals
Interventions: DIETARY_SUPPLEMENT: Folic acid|DIETARY_SUPPLEMENT: 5-methyltetrahydrofolate, calcium salt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Selumetinib (MK-5618) in Combination With Pembrolizumab (MK-3475) in Participants With Advanced/Metastatic Solid Tumors (MK-5618-001)
Status: COMPLETED
Conditions: Advanced/Metastatic Solid Tumors
Interventions: DRUG: Selumetinib|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Marijuana Smoked in Cigarette Paper Versus Cigar Paper
Status: COMPLETED
Conditions: Marijuana Dependence
Interventions: DRUG: Marijuana blunt|DRUG: marijuana cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: MBSR During AI Therapy for Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Cognitive Symptom
Interventions: BEHAVIORAL: Health Enhancement Program|BEHAVIORAL: Mindfulness-Based Stress Reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: BPF Genetics of ILD Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung; Disease, Interstitial, With Fibrosis|Alveolitis, Extrinsic Allergic|Bird Fancier's Lung|Idiopathic Interstitial Pneumonias|Lung Diseases, Interstitial|Idiopathic Pulmonary Fibrosis
Interventions: DIAGNOSTIC_TEST: Genetic profiling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Oral Roflumilast Taken With Low Dose Inhaled Corticosteroids in Patients With Asthma (12 to 70 y) (BY217/M2-013)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Roflumilast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy and Safety of Combined Treatment of Patients With Severe Herpes Simplex (HSV) Infection by Valacyclovir and Interferon Inducer Kagocel
Status: COMPLETED
Conditions: Herpes|Herpes Simplex|Herpes Oral|Herpes Simplex 2|Herpes Genitalis
Interventions: DRUG: Kagocel+Valacyclovir|DRUG: Valacyclovir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ketoconazole, Hydrocortisone and Dutasteride in Asymptomatic Hormone Refractory Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Ketoconazole, Hydrocortisone and Dutasteride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Flap With Platelet Rich Fibrin or Growth Factor Enhanced Matrix in Treatment of Intrabony Defect
Status: COMPLETED
Conditions: Periodontal Regeneration
Interventions: PROCEDURE: Minimal invasive flap technique|PROCEDURE: Minimally invasive flap with root conditioning (EDTA) and platelet rich fibrin|COMBINATION_PRODUCT: minimally invasive flap with root contioning by EDTA and growth factor enhanced matrix GEM21S
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Lamivudine Extending Therapy in Chronic Hepatitis B Patients After 3-year of Oral Antiviral Agents
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-operative Magnesium Sulphate for Post-operative Pain in Patients Undergoing Total Abdominal Hysterectomy Under General Anesthesia
Status: RECRUITING
Conditions: Post-operative Pain
Interventions: DRUG: Magnesium sulfate|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of NVXT Solution in Mild-to-Moderate Fungal Infection of the Toe Nail
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DRUG: NVXT Solution|DRUG: Vehicle of test product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Social and Financial Incentives to Increase Physical Activity Among Overweight and Obese Veterans
Status: COMPLETED
Conditions: Physical Activity
Interventions: BEHAVIORAL: Social Incentive Gamification|BEHAVIORAL: Support Sponsor|BEHAVIORAL: Financial Incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Extended Follow-up of Patients With Macular Edema Due to Retinal Vein Occlusion
Status: COMPLETED
Conditions: Retinal Vein Occlusion
Interventions: DRUG: ranibizumab|OTHER: Peripheral Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can the Ratio of Chin-neck Circumference and Neck Circumference to Chin-neck Circumference Predict Difficult Intubation in Obese Patients?
Status: COMPLETED
Conditions: Difficult Airway Intubation|Obesity Adult Onset
Interventions: OTHER: intubation|OTHER: mask ventilation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rechallenge of Prior Regimen in Third or Later-line Chemotherapy in Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer|Chemotherapy Effect
Interventions: DRUG: the rechallenge regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Spinal Cord Stimulation With Automatic Control to Treat Chronic Pain in an Extended Trial
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DEVICE: Saluda Medical External Trial System|DEVICE: Saluda Medical External Trial System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biospecimens for Identification of Diseases of the Pancreas.
Status: COMPLETED
Conditions: Pancreatic Cancer|Chronic Pancreatitis|Type II Diabetes|Pancreatic Cysts|Healthy Control
Interventions: PROCEDURE: Blood Draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Acupuncture Approaches for Chronic Pain
Status: COMPLETED
Conditions: Chronic Pain|Osteoarthritis|Neck Pain|Back Pain
Interventions: PROCEDURE: Group/Community Acupuncture|PROCEDURE: Individual Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Exposure to Simulated Hypoxia on Exercise Capacity
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DEVICE: Simulated Altitude (FiO2: 15.1%)|DEVICE: Shamed Hypoxia (FiO2: 20.9)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Using Capnography to Reduce Hypoxia During Pediatric Sedation
Status: COMPLETED
Conditions: Hypoventilation|Hypoxia
Interventions: DEVICE: Nellcor NPB-70 Capnograph
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: DSAEK- Postoperative Positioning and Transplant Dislocation
Status: UNKNOWN
Conditions: Corneal Transplantation|Descemet Stripping Automated Endothelial Keratoplasty|Fuchs' Endothelial Dystrophy|Corneal Dystrophies, Hereditary
Interventions: OTHER: Postoperative positioning: Bed rest|OTHER: Postoperative positioning: Sitting up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the antiCD38 Monoclonal Antibody Isatuximab in the Treatment of PCRA by Major ABO Mismatch After Allogeneic Hematopoietic Stem Cell Transplantation
Status: NOT_YET_RECRUITING
Conditions: Immunological Pure Red Cell Aplasia
Interventions: DRUG: Isatuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Healing Light Algorithms for Nurses in the ICU
Status: ACTIVE_NOT_RECRUITING
Conditions: Critical Care|Phototherapy
Interventions: DEVICE: Dynamic Light Therapy Device, LSA-1|DEVICE: Dynamic Light Therapy Device, LSA-2|DEVICE: Dynamic Light Therapy Device, LSA-3
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Immunogenicity and Pharmacokinetics of SYN004 in Patients With Solid Tumors
Status: COMPLETED
Conditions: Colon Cancer, Breast Cancer, Cancer of the Head and Neck
Interventions: BIOLOGICAL: SYN004
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SPC3649 Multiple Dose Study in Healthy Volunteers
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: SPC3649|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Selected Vegetable and Herb Mix (SV) on Advanced Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Selected Vegetable and Herb Mix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation for Psychological Distress in Patients With Advanced Illness
Status: RECRUITING
Conditions: Depressive Symptoms|Depression, Anxiety|Psychological Distress|Terminal Illness
Interventions: DEVICE: repetitive Transcranial Magnetic Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of OP-101 After Intravenous Administration in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: OP-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EMD 1201081 + 5-FU + Cisplatin + Cetuximab in Subjects With Recurrent / Metastatic Squamous Cell Carcinoma of the Head and Neck
Status: TERMINATED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: EMD 1201081 + 5-FU + Cisplatin + Cetuximab|DRUG: EMD 1201081 + 5-FU + Cisplatin + Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Food Compositions on Bioavailability of BIIL 284 BS in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIIL 284 BS|OTHER: high fat meal|OTHER: low fat meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled HD-tDCS Trial: Effects on Tinnitus Severity and Cognition
Status: COMPLETED
Conditions: Tinnitus
Interventions: DEVICE: tDCS|DEVICE: sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy - Safety of Eflornithine-Nifurtimox Combination Versus Eflornithine to Treat Human African Trypanosomiasis
Status: COMPLETED
Conditions: Trypanosomiasis, African
Interventions: DRUG: Eflornithine|DRUG: Nifurtimox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerance of 4 Weeks of Tedizolid in Prosthetic Joint Infections Treated With Implant Removal
Status: UNKNOWN
Conditions: Prostheses Infection
Interventions: DRUG: Sivextro 200 milligrams Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SAHA + CHOP in Untreated T-cell Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Zolinza (vorinostat)|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of ACT-based Interventions on Diabetes-related Outcomes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Values-plus-goals intervention|BEHAVIORAL: Mindfulness-based intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of Valsartan / Amlodipine From Valsartan and Amlodipine Tablets (Hua Yuan Pharmaceutical LLC, China) and Valsartan and Amlodipine Tablets (Ⅰ) (Novartis Pharma Schweiz AG, Switzerland)
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: Valsartan and Amlodipine Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase II Imatinib + Hydroxyurea in Treatment of Patients With Recurrent/Progressive Grade II Low-Grade Glioma (LGG)
Status: COMPLETED
Conditions: Glioblastoma|Gliosarcoma
Interventions: DRUG: Imatinib Mesylate & Hydroxyurea
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation The Efficacy of Manual Therapy and Exercise in Patients With Glenohumeral Arthritis
Status: COMPLETED
Conditions: Glenohumeral Arthritis
Interventions: OTHER: Manuel Therapy plus Exercise Intervention|OTHER: Exercise Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Study With GLPG3667 and Midazolam in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG3667|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Empagliflozin on Cardiac Microvasculature and Insulin Sensitivity in Subjects With Type 2 Diabetes
Status: UNKNOWN
Conditions: Type2 Diabetes|Insulin Sensitivity
Interventions: DRUG: Empagliflozin 25 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Influence of an Inverse Pressure Ramp in Long-term Non-invasive Ventilation on Dyspnea in the Morning After Therapy
Status: TERMINATED
Conditions: Noninvasive Ventilation|Dyspnea
Interventions: OTHER: softSTOPP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Prior to Injection and Biopsy of the Vulva
Status: TERMINATED
Conditions: Vulvar Diseases|Anesthesia|Anesthesia, Local
Interventions: OTHER: Ice Pre-treatment|OTHER: Room Temperature Water Pre-treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma
Status: RECRUITING
Conditions: Medulloblastoma|Glioblastoma Multiforme|Anaplastic Astrocytoma|High-grade Astrocytoma NOS|Anaplastic Oligodendroglioma|Anaplastic Ependymoma|Ependymoma|Diffuse Intrinsic Pontine Glioma
Interventions: BIOLOGICAL: SurVaxM for patients with relapsed or progressive MB, HGG or ependymoma ages ≥10 and ≤21 years|BIOLOGICAL: SurVaxM for patients with relapsed or progressive MB, HGG or ependymoma ages ≥1 and <10 years|BIOLOGICAL: SurVaxM for patients with non-relapsed DIPG post radiation-therapy ages ≥1 and ≤21 years
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IL13-PE38QQR Infusion After Tumor Resection, Followed by Radiation Therapy With or Without Temozolomide in Patients With Newly Diagnosed Malignant Glioma
Status: COMPLETED
Conditions: Glioblastoma Multiforme|Anaplastic Astrocytoma|Oligoastrocytoma
Interventions: DRUG: IL13-PE38QQR|PROCEDURE: Surgery for placement|PROCEDURE: Radiation therapy|DRUG: Temozolomide with radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Dose PD & PK Study With Two Formulations of Abediterol in Patients With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Abediterol 0.156 μg|DRUG: Abediterol 2.5 μg|DRUG: Abediterol 0.05 μg|DRUG: Abediterol 0.156 μg|DRUG: Abediterol 2.5 μg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Tolerability Study of Levalbuterol HFA Metered Dose Inhaler in Subjects With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Levalbuterol HFA MDI followed by Racemic albuterol HFA MDI|DRUG: Racemic Albuterol followed by levalbuterol HFA MDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma
Status: COMPLETED
Conditions: Triple Negative Breast Cancer|Endometrial Cancer|Hormone Receptor Positive, HER2 Negative Breast Cancer
Interventions: DRUG: ONC201
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CompuFlo® Assessment Study for the Epidural Space Verification
Status: UNKNOWN
Conditions: Verification of Needle Tip Placement in the Lumbar Epidural Space
Interventions: DEVICE: Active: Comparator Loss Of Resistance Syringe|DEVICE: Experimental: CompuFlo® Epidural System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Esomeprazole 20 mg or 40 mg vs Placebo Effectiveness on the Occurrence of Peptic Ulcers in Subjects on Low Dose Acetylsalicylic Acid (LDA)
Status: COMPLETED
Conditions: Gastric Ulcer|Duodenal Ulcer
Interventions: DRUG: Esomeprazole 40 mg|DRUG: Esomeprazole 20 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prerecorded Autosuggestion in Long-standing Pain Intervention
Status: UNKNOWN
Conditions: Pain
Interventions: OTHER: care as usual + 5 specific CDs|OTHER: care as usual + email assistance + AurelisOnLine (AoL) + CDs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tourniquet Use in Anterior Cruciate Ligament Repair
Status: ENROLLING_BY_INVITATION
Conditions: ACL - Anterior Cruciate Ligament Deficiency|ACL Injury|ACL Tear
Interventions: PROCEDURE: Patients undergoing ACL reconstruction with or without a tourniquet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Labour Progression Study, a Cluster Randomised Trial on Labour Progression for First Time Mothers
Status: ACTIVE_NOT_RECRUITING
Conditions: Caesarean Sections|Augmentation With Oxytocin|Labour Dystocia
Interventions: OTHER: Dynamic progression curve|OTHER: Static labour progression curve (F)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of BMS-582664 in Combination With Either FOLFIRI or FOLFOX for Gastrointestinal (GI) Malignancies
Status: TERMINATED
Conditions: Gastrointestinal Neoplasms
Interventions: DRUG: BMS-582664
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Selective Blockade of the Saphenous and Obturator Nerves Following Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Arthroplasty, Total
Interventions: DRUG: nerve block with ropivacaine|DRUG: nerve block with ropivacaine and with saline|DRUG: nerve block with saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Candy Flavoring Before Local Anesthesia on Anxiety and Pain Perception in Children
Status: COMPLETED
Conditions: Local Anesthesia
Interventions: PROCEDURE: Local Anesthesia 1|PROCEDURE: Local Anesthesia 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Measurements of Displacement Amplitude and Angular Velocities During Passive Extension of the Wrist and Hand Complex in Stroke Patients
Status: TERMINATED
Conditions: Muscle Spasticity|Stroke
Interventions: PROCEDURE: Passive extension mobilization of the hand and wrist joints
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of the Safety and Efficacy of Ustekinumab in Adolescent Patients With Psoriasis (CADMUS)
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Ustekinumab - Half-Standard Dosage|DRUG: Ustekinumab - Standard Dosage|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of AVE5530 as add-on to Ongoing Statins in Patients With Primary Hypercholesterolemia
Status: TERMINATED
Conditions: Hypercholesterolemia
Interventions: DRUG: 25 mg/day AVE5530|DRUG: 50 mg/day AVE5530|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Plant and Animal Proteins on Biomarkers of Colorectal Cancer and Type 2 Diabetes in Healthy Adults (ScenoProt)
Status: COMPLETED
Conditions: Colorectal Cancer|Type2 Diabetes
Interventions: OTHER: 70% animal, 30% plant proteins in diet|OTHER: 50% animal, 50% plant proteins in diet|OTHER: 30% animal, 70% plant proteins in diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phenylephrine Versus Eyelid Taping for Muller's Muscle-Conjunctival Resection (MMCR) Evaluation
Status: RECRUITING
Conditions: Ptosis, Eyelid
Interventions: DRUG: Phenylephrine Ophthalmic|OTHER: Eyelid Tape
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noninterventional Observational Prospective Longitudinal Study of the Incidence of Ulcerative Colitis and Crohn's Disease Among the Adult Population of the Republic of Kazakhstan
Status: RECRUITING
Conditions: Ulcerative Colitis Chronic|Crohn Disease Colon
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preventing Depression in People Receiving Mechanical Ventilation in an Intensive Care Unit
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Escitalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Novel Silk Fibroin Nanofiber Membrane Using Minimally Invasive Surgery in Treatment of Periodontal Intrabony Defects: A Randomized Clinical Trial
Status: COMPLETED
Conditions: Intrabony Periodontal Defect
Interventions: PROCEDURE: Minimally Invasive Surgery Technique (MIST) + Novel Silk Fibroin (SF) nanofiber membrane|PROCEDURE: Minimally Invasive Surgery Technique (MIST) + collagen membrane|PROCEDURE: Minimally Invasive Surgery Technique (MIST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Modified 3D Printed Customized Facemask Appliance for Treatment of Class III Malocclusion
Status: RECRUITING
Conditions: Jaw Protrusions
Interventions: DEVICE: Modified 3D printed facemask|DEVICE: Conventional facemask appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Intravascular Fluid Resuscitation and Whole Blood Viscosity for CABG Surgery
Status: UNKNOWN
Conditions: CABG Surgery
Interventions: DRUG: Intravenous Crystalloid|DRUG: Intravenous HES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adult Primary Insomnia Polysomnographic Study (0928-004)(COMPLETED)
Status: COMPLETED
Conditions: Primary Insomnia
Interventions: DRUG: gaboxadol|DRUG: Comparator: placebo (unspecified)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dual-targeting VEGFR1 and PD-L1 CAR-T for Cancers Patients With Pleural or Peritoneal Metastases
Status: RECRUITING
Conditions: Malignant Peritoneal Effusion|Malignant Ascites|Serous Cavity Metastatises
Interventions: BIOLOGICAL: Dual-targeting VEGFR1 and PD-L1 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EFFECTS OF BODY-BLADE EXERCISES ON NECK POSTURE, FUNCTION, AND MUSCLE STRENGTH IN FORWARD HEAD POSTURE
Status: UNKNOWN
Conditions: Forward Head Posture
Interventions: OTHER: hot pack and exercises|DEVICE: body blade(BB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Integrated Model for Promoting Parenting and Early School Readiness in Pediatrics
Status: ACTIVE_NOT_RECRUITING
Conditions: Infant Behavior|Child Behavior|Parenting|Child Rearing|Depression|Personal Satisfaction|Behavioral Symptoms|Social Control, Informal
Interventions: BEHAVIORAL: Video Interaction Project|BEHAVIORAL: Family Check Up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Feasibility and Acceptability of Non Weight-bearing Physical Activity for People With Diabetic Foot Ulceration
Status: NOT_YET_RECRUITING
Conditions: Diabetic Foot|Cardiopulmonary|Physical Inactivity
Interventions: BEHAVIORAL: Non weight-bearing physical activity program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guyded Venous Puncture for Safe AF Ablation Procedures
Status: RECRUITING
Conditions: Puncture for Safe Atrial Fibrillation Ablation
Interventions: OTHER: Ultrasound guided venous access during AF ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Topical 0.2% Loteprednol Etabonate vs. Topical 0.1% Dexamethasone in Impending Recurrent Pterygium
Status: COMPLETED
Conditions: Recurrent Pterygium of Eye|Steroid-Induced Glaucoma
Interventions: DRUG: 0.2% loteprednol etabonate|DRUG: 0.1% dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Training Intervention and Program of Support (TIPS): Fostering Family-centred Telehealth in Pediatric Rehabilitation
Status: RECRUITING
Conditions: Telerehabilitation
Interventions: BEHAVIORAL: Training Intervention and Program of Support (TIPS) for fostering the adoption of family-centred telehealth interventions in pediatric rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Non-ischaemic Heart Preservation Versus Standard Cold Storage in Human Heart Transplantation
Status: ENROLLING_BY_INVITATION
Conditions: Transplant; Failure, Heart
Interventions: DEVICE: Non-ischemic heart preservation (NIHP)|DEVICE: Standard ischemic cold static storage (SCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Two Weeks of Reduced Activity and Skeletal Muscle Health in Older Men
Status: COMPLETED
Conditions: Muscular Atrophy
Interventions: BEHAVIORAL: Step-reduction|BEHAVIORAL: Pre-training|BEHAVIORAL: Exercise snacking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: ARC1905 (ANTI-C5 APTAMER) Given Either In Combination Therapy With Lucentis® 0.5 mg/Eye In Subjects With Neovascular Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: ARC1905
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Investigating the Effect of NN1250 in Japanese Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin degludec|DRUG: insulin detemir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Randomized Controlled Trial of Obstructed Defecation Surgery
Status: RECRUITING
Conditions: Obstructed Defecation
Interventions: PROCEDURE: Laparoscopic abdominal ventral rectopexy|PROCEDURE: Transvaginal sacrospinous rectopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coronary Microvascular Dysfunction in Chronic Kidney Disease
Status: UNKNOWN
Conditions: Kidney Disease, Chronic|Myocardial Dysfunction
Interventions: DIAGNOSTIC_TEST: Coronary flow reserve assessment|DIAGNOSTIC_TEST: Sphygmocor|DIAGNOSTIC_TEST: Electrocardiogram|OTHER: Blood test|OTHER: Urinary albumin/creatinine ratio
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PHESGO Maintenance After T-DXd Short Induction for HER2+ Unresectable Locally Recurrent or Metastatic Breast Cancer
Status: RECRUITING
Conditions: HER2-positive Breast Cancer
Interventions: DRUG: Trastuzumab deruxtecan|DRUG: Phesgo 1,200 MG / 600 MG / 30,000 UNT Per 15 ML Injection|DRUG: Phesgo 600 MG / 600 MG / 20,000 UNT in 10 mL Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Anesthetics on Postsurgical Analgesia Following Posterior Colporrhaphy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Exparel plus plain bupivacaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes of Bromday (Bromfenac Ophthalmic Solution) 0.09% QD vs. Nevanac (Nepafenac Ophthalmic Suspension) 0.1%
Status: COMPLETED
Conditions: Inflammation|Pseudophakia
Interventions: DRUG: Bromfenac|DRUG: Nepafenac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of the Spatial Resolution of Several Contrast-enhanced 3D T1-WI Sequences When Diagnosing Giant Cell Arteritis (GCA)
Status: NOT_YET_RECRUITING
Conditions: Giant Cell Arteritis
Interventions: DIAGNOSTIC_TEST: 3D T1 MRI sequences injected with fat saturation and black blood
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TC-325 (HEMOSPRAY™) VS. CURRENT STANDARD OF CARE IN MANAGING MALIGNANT GASTROINTESTINAL BLEEDING: A PILOT STUDY TO INFORM A RANDOMIZED CONTROLLED TRIAL.
Status: COMPLETED
Conditions: MALIGNANT GASTROINTESTINAL BLEEDING
Interventions: DRUG: TC-325 monotherapy on initial endoscopy ± radiation therapy, angioembolization, and/or surgery.|OTHER: Current standard therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Supplementation of Vitamin D in Patients With Type 2 Diabetes and Hypertension
Status: TERMINATED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: supplementation of 100.000 IU of vitamin D3|DIETARY_SUPPLEMENT: placebo pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Genotype-guided Strategy for Antithrombotic Treatment in Peripheral Arterial Disease.
Status: RECRUITING
Conditions: Peripheral Arterial Disease
Interventions: GENETIC: Direct CYP2C19 genotyping|GENETIC: CYP2C19 genotyping at the end of the study|DRUG: Poor metabolisers|DRUG: Intermediate metabolisers|DRUG: Normal metabolisers and unknown metaboliser state
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Personalized Management of Psycho-behavioral Symptoms in Alzheimer's Disease: Impact on Health Resources Use
Status: RECRUITING
Conditions: Alzheimer's Disease
Interventions: BEHAVIORAL: personalized care preceded by a standardized assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Machine Learning Diagnosis and Prediction for Cervical Myelopathy
Status: UNKNOWN
Conditions: Cervical Myelopathy
Interventions: OTHER: The questionnaire "Cervical myelopathy treatment outcome questionnaire"|OTHER: The retrospective questionnaire "CSM early diagnosis questionnaire"|OTHER: JOACMEQ questionnaire and mJOA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Gemcitabine, Nab-Paclitaxel, Cisplatin and Anakinra Treatment on Patients With Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma
Interventions: DRUG: Nab-paclitaxel|DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Anakinra
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Motivational Interviewing to Prevent Suicide in High Risk Veterans
Status: COMPLETED
Conditions: Suicidal Ideation|Treatment Engagement
Interventions: BEHAVIORAL: MI-SI+TAU|BEHAVIORAL: MI-SI-R+TAU|OTHER: TAU Alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Epanova® for Lowering Very High Triglycerides
Status: COMPLETED
Conditions: Severe Hypertriglyceridemia
Interventions: DRUG: placebo|DRUG: omefas|DRUG: omefas|DRUG: omefas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Confirm the Efficacy and Safety of K-161 Ophthalmic Solution for Treatment of Moderate to Severe Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: K-161|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Firearm-Safety Counseling: Medical Student Training
Status: ACTIVE_NOT_RECRUITING
Conditions: Medical Student Firearm Epidemiology Knowledge|Medical Student Firearm Safety Knowledge|Medical Student Initiated Clinical Firearm Safety Counseling
Interventions: BEHAVIORAL: Clinical Firearm Safety Counseling Module
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Kettlebell Training on Musculoskeletal and Cardiovascular Health
Status: COMPLETED
Conditions: Musculoskeletal Disorders
Interventions: BEHAVIORAL: Ketllebell training|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial for Evaluating Efficacy and Safety of PDR001 in Concurrent Plus Consolidation Versus Consolidation Only in Addition to Standard Chemoradiotherapy in Unresectable Stage III NSCLC Patients (PASTURE)
Status: WITHDRAWN
Conditions: Stage III NSCLC
Interventions: DRUG: standard platinum-based concurrent chemoradiotherapy, followed by consolidation with PDR001|DRUG: PDR001 concurrent with standard platinum-based chemoradiation, followed by consolidation with PDR001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Assess Absorption Of Study Drug Dacomitinib (PF-00299804), Given As An Oral Tablet Compared To An Intravenous Infusion In Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: dacomitinib oral|DRUG: dacomitinib intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Chemotherapy With Low-Dose Radiation for Pediatric Hodgkin Lymphoma
Status: COMPLETED
Conditions: Hodgkin's Lymphoma
Interventions: DRUG: Adriamycin®|DRUG: Vinblastine|DRUG: Nitrogen Mustard|DRUG: Cyclophosphamide|DRUG: Vincristine|DRUG: Bleomycin|DRUG: Etoposide|DRUG: Prednisone|BIOLOGICAL: G-CSF|PROCEDURE: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Catheter Ablation of Arrhythmias to Improve CRT Response
Status: TERMINATED
Conditions: Arrhythmia, Cardiac
Interventions: PROCEDURE: Catheter Ablation|DRUG: Anti-Arrhythmics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intraoperative NGAL Level in Geriatric Patients Undergoing Laparotomy
Status: COMPLETED
Conditions: Geriatric Presentation of Urinary Tract Infection|Acute Kidney Injury
Interventions: DIAGNOSTIC_TEST: record of pNGAL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cardiorespiratory Fitness Training in Patients With Incomplete Spinal Cord Injury
Status: NOT_YET_RECRUITING
Conditions: Incomplete Spinal Cord Injury|Exercise Training
Interventions: OTHER: Cardiorespiratory fitness (CRF) training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selective Pulmonary-artery Intervention to Reduce Acute Right-heart tEnsion-II
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Embolism
Interventions: DEVICE: Vertex Pulmonary Embolectomy System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of the Genetic Causes of Rare Diseases With Negative Exome Findings
Status: RECRUITING
Conditions: Rare Diseases|Genetic Predisposition to Disease
Interventions: GENETIC: WGS Diagnostic Blood take for genetic diagnostic.|GENETIC: Hair collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Different Approaches to Maternal Hypotension During Cesarean Section
Status: COMPLETED
Conditions: Pregnancy|Cesarean Section|Anesthesia,Spinal|Hypotension
Interventions: DRUG: Bupivacaine|DRUG: Morphine|DRUG: Lactated Ringer's solution|DRUG: Ephedrine, continuous infusion|DRUG: Ephedrine, bolus|DRUG: Atropine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Neuro-navigational Systems for Resection-Control of Brain Tumors
Status: UNKNOWN
Conditions: Glioma
Interventions: DEVICE: Intraoperative MR (PoleStar N-20, Medtronics)|DEVICE: Intraoperative Ultrasound (Sonowand, Mison)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cryotherapy Post-haemorrhoidectomy (CYPHER) Randomized Controlled Trial
Status: RECRUITING
Conditions: Hemorrhoids|Postoperative Pain|Postoperative Complications|Cryotherapy Effect
Interventions: DEVICE: Transanal ice pack
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Drug-Drug Interactions of Androxal With Cytochrome P450 Isoenyzmes in Healthy Males
Status: COMPLETED
Conditions: Drug-drug Interaction
Interventions: DRUG: Androxal|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electric Stimulation on Nausea and Vomit Chemotherapy Induced
Status: UNKNOWN
Conditions: Breast Cancer Female|Acupuncture
Interventions: DEVICE: Placebo Group|DEVICE: Low Frequency Group|DEVICE: High Frequency Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Maintenance Therapy With Toripalimab Combined With Capecitabine/Placebo for Recurrent and Metastatic Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma|Maintenance Therapy
Interventions: DRUG: Capecitabine/Placebo combined with toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Durvalumab in Combination With Tremelimumab in Malignant Pleural Mesothelioma
Status: SUSPENDED
Conditions: Mesothelioma
Interventions: DRUG: Tremelimumab|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of Oral Amino Acid Tracers to Study Protein Turnover in Humans
Status: COMPLETED
Conditions: Healthy Adult Males
Interventions: DIETARY_SUPPLEMENT: Crystalline amino acids to assess myofibrillar protein synthesis rates|DIETARY_SUPPLEMENT: Crystalline amino acids to assess whole-body protein turnover, amino acid oxidation, and net protein balance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Wearable With Photoplethysmography and 6-lead Electrocardiography for Atrial Fibrillation Detection
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Monitoring with wearable (the tested device) and Holter ECG (eMotion Faros 90)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p