pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Nivolumab and Axitinib in Patients With Advanced Renal Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Nivolumab|DRUG: Axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Pain Control by Use of Many Drugs in Small Doses Intrathecally
Status: UNKNOWN
Conditions: Post Operative Pain
Interventions: DRUG: Morphine Sulfate|DRUG: Bupivacaine|DRUG: dexamethasone, morphine, midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Pilot Study of Circulating Tumor DNA Adaptive Risk Maintenance Approach for Bladder Cancer (CARMA)
Status: WITHDRAWN
Conditions: Metastatic Urothelial Carcinoma
Interventions: DRUG: Pembrolizumab (200mg)|DRUG: Pembrolizumab (400mg)|DIAGNOSTIC_TEST: Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurostimulation for Dysphagia in Parkinson's Disease
Status: COMPLETED
Conditions: Dysphagia|Parkinson Disease|Swallowing Disorder.Other Specified|Brain Diseases
Interventions: DEVICE: repetitive magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Telapristone Acetate (Proellex®) in the Treatment of Pre-Menopausal Women With Confirmed, Symptomatic Endometriosis
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: Placebo|DRUG: Telapristone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Adipose-Derived Regenerative Cells for the Treatment of Critical Lower Limb Ischemia
Status: UNKNOWN
Conditions: Critical Limb Ischemia|Arteriosclerosis Obliterans|Peripheral Arterial Disease|Thromboangiitis Obliterans|Diabetic Angiopathies
Interventions: PROCEDURE: ADRC injection|OTHER: ADRC isolation|PROCEDURE: Liposuction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DCSZ11 as a Monotherapy and in Combination in Patients With Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Advanced or Metastatic Solid Tumors
Interventions: DRUG: DCSZ11|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Booster Vaccination With Pediacel® to Infanrix® Hexa When Both Are Co-Administered With Prevenar®
Status: COMPLETED
Conditions: Infant|Healthy
Interventions: BIOLOGICAL: DT5aP-IPV-Hib 5-component Pertussis vaccine|BIOLOGICAL: DT3aP-HBs-IPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Immunonutrients on Oral Mucositis in Nasopharyngeal Carcinoma Patients After Chemoradiotherapy
Status: RECRUITING
Conditions: Locally Advanced Nasopharyngeal Carcinoma
Interventions: DIETARY_SUPPLEMENT: Enteral immunonutrition|DIETARY_SUPPLEMENT: Standard enteral nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Novel Optical Surface Image Guidance System for Beam-Gated Online Adaptive SBRT Delivery in Mobile Lower Lung and Upper Abdominal Malignancies
Status: COMPLETED
Conditions: Any Solid Malignancies of Any Tissue Origin (Except for Small Cell Lung Cancer) Involving the Upper Abdomen and Thorax
Interventions: DEVICE: ETHOS|RADIATION: CT-guided stereotactic adaptive radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnesium Sulfate Effect Following the Reversal of Neuromuscular Blockade Induced by Rocuronium With Sugammadex
Status: COMPLETED
Conditions: Neuromuscular Blockade
Interventions: DRUG: Magnesium Sulfate|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Laser Treatment on Macular Pigment of Eye in Cases With Diabetes
Status: COMPLETED
Conditions: Diabetic Retinopathy|Retinal Degeneration|Macula Abnormality|Laser Burn of Retina
Interventions: DEVICE: Laser pan-retinal photocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risperidone and Suicidality in Major Depressive Disorder
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Risperidone and placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Trendelenburg Lithotomy Position on Pain and Procedural Time During Vaginoscopic Office Hysteroscopy
Status: COMPLETED
Conditions: Uterine Diseases
Interventions: PROCEDURE: vaginoscopic office hysteroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Changes Induced by Early HABIT-ILE in Pre-school Children With Uni- and Bilateral Cerebral Palsy
Status: UNKNOWN
Conditions: Cerebral Palsy
Interventions: BEHAVIORAL: HABIT-ILE|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Specific Protocoled Physiotherapy Treatment for Subjects Surgically Treated for Femoroacetabular Syndrome
Status: COMPLETED
Conditions: Hip Injuries
Interventions: PROCEDURE: Physiotherapy post-surgical protocol for femoroacetabular impingement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a 1-Millimeter Resolution Clinical Positron Emission Tomography (PET) System in Head and Neck Cancer Imaging
Status: NOT_YET_RECRUITING
Conditions: Head and Neck Cancer
Interventions: DEVICE: 1-mm Resolution Clinical PET camera
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Evaluate Whether Combination Therapy With Methotrexate and Raptiva in Psoriasis Patients is Safe and Increases Efficacy
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Methotrexate|DRUG: Raptiva
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Suvorexant for Sleep in Children With Autism
Status: RECRUITING
Conditions: Autism|Autism Spectrum Disorder
Interventions: DRUG: Suvorexant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Submaximal Cardiopulmonary Exercise Testing for Detection of Myocardial Injury After Noncardiac Surgery
Status: NOT_YET_RECRUITING
Conditions: Myocardial Injury After Non-cardiac Surgery|Submaximal Exercise Performance|Preoperative Period
Interventions: DIAGNOSTIC_TEST: High-sensitivity troponin, serum|DIAGNOSTIC_TEST: Submaximal Cardiopulmonary Exercise Testing|DIAGNOSTIC_TEST: Duke Activity Status Index
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cellular Immunotherapy for Patients With High Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Myelodysplastic Syndromes|Acute Myeloid Leukemia
Interventions: BIOLOGICAL: Autologous dendritic cells electroporated with WT1 mRNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiosensitization of Multiple Brain Metastases Using AGuIX Gadolinium Based Nanoparticles
Status: COMPLETED
Conditions: Brain Metastases
Interventions: DRUG: AGuIX|RADIATION: whole brain radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post Transplant Cyclophosphamide (Cytoxan) for GvHD Prophylaxis
Status: COMPLETED
Conditions: Leukemia|Lymphoma|Myelodysplastic Syndrome|Myelofibrosis|Severe Aplastic Anemia|Allogeneic Transplant
Interventions: DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Crossover Trial of Systemic Chemotherapy in Patients With Metastatic Well-Differentiated Mucinous Appendiceal Adenocarcinomas With Pseudomyxoma Peritonei
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastrointestinal Neoplasms
Interventions: BEHAVIORAL: Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Non-surgical Step 3 Periodontal Treatment With/Without Adjunctive Protocol - Pilot RCT.
Status: COMPLETED
Conditions: Periodontal Pocket
Interventions: BIOLOGICAL: subgingival instrumentation plus Perisolv / hyaDent BG|PROCEDURE: subgingival instrumentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Hemodynamically Oriented Echocardiography-Based Strategy in the Treatment of Congestive Heart Failure
Status: TERMINATED
Conditions: Heart Failure
Interventions: PROCEDURE: Hemodynamically Oriented Echocardiography-based Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Infections in Hip Arthroplasty Loosening.
Status: COMPLETED
Conditions: Loosening, Prosthesis
Interventions: DIAGNOSTIC_TEST: Microbiological analysis of periprosthetic tissue|DIAGNOSTIC_TEST: Histological analysis of periprosthetic tissue|OTHER: Characterization of tissue microbiota|OTHER: Characterization of gut microbiota|OTHER: Characterization of oral microbiota
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Platelet-rich Fibrin and Autogenous Bone vs Membrane and Autogenous Bone in Intrabony Defects
Status: COMPLETED
Conditions: Periodontal Bone Loss
Interventions: PROCEDURE: Procedure/Surgery: Periodontal surgery with Membrane|PROCEDURE: Periodontal surgery with Platlet Rich fibrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prospective Trial on Noise Reduction in Surgical Operating Theaters
Status: COMPLETED
Conditions: Efficacy of a Noise Reduction Program|Surgical Complications|Sound Pressures in the Operating Theatre
Interventions: BEHAVIORAL: Noise reduction work place rules|BEHAVIORAL: Presence of an examiner in the concerned theatre
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bimatoprost in the Treatment of Eyelash Hypotrichosis
Status: COMPLETED
Conditions: Idiopathic Eyelash Hypotrichosis
Interventions: DRUG: bimatoprost formulation A solution|DRUG: bimatoprost solution 0.03 %|DRUG: vehicle of bimatoprost formulation A solution|DRUG: vehicle of bimatoprost solution 0.03 %
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial on Harmonic Focus Shears Versus Ligasure Small Jaw and Clamp-and-tie Technique for Total Thyroidectomy
Status: COMPLETED
Conditions: Benign Thoroid Disease Requiring Total Thyroidectomy
Interventions: PROCEDURE: Total Thyroidectomy with cut and tie technique vs Total Thyroidectomy with Ligasure Small-JAW vs Total Thyroidectomy with Harmonic Focus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Merits of Continuous Paravertebral Block in the Management of Renal/Adrenal Surgery by Laparotomy
Status: TERMINATED
Conditions: Indication for Renal and/or Adrenal Surgery
Interventions: PROCEDURE: Continuous Paravertebral block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: tVNS During Motor Training in Older Adults
Status: NOT_YET_RECRUITING
Conditions: Older Adults
Interventions: PROCEDURE: tVNS stimulation|PROCEDURE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Clinical Study in Patients With Overactive Bladder With Leakage of Urine, to Find Out if the Medicine, Fesoterodine, Works in Those Patients Who Did Not Have Enough Response to the Medicine, Tolterodine.
Status: COMPLETED
Conditions: Urinary Bladder, Overactive
Interventions: DRUG: Fesoterodine 8 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lymphocytic B-Leukemia (B-CLL) w/Human IL-2 Gene Modified & Human CD40 Ligand-Expressing Autologous Tumor Cells
Status: WITHDRAWN
Conditions: CHRONIC LYMPHOCYTIC B-LEUKEMIA
Interventions: BIOLOGICAL: IL-2 secreting and hCL4OL-expressing autologous B-CLL cells|BIOLOGICAL: IL-2|BIOLOGICAL: CD40L|DRUG: ONTAK|BIOLOGICAL: immunotoxin dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Familiar Lymphohistiocytosis
Status: COMPLETED
Conditions: Hemophagocytic Lymphohistiocytosis (HLH)
Interventions: DRUG: Alemtuzumab|DRUG: Methyl Prednisolone (MP)|DRUG: Cyclosporin A (CSA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Akt Inhibitor MK2206 and Hydroxychloroquine in Treating Patients With Advanced Solid Tumors, Melanoma, Prostate or Kidney Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Stage III Cutaneous Melanoma AJCC v7|Stage III Prostate Cancer AJCC v7|Stage III Renal Cell Cancer AJCC v7|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7|Stage IV Prostate Cancer AJCC v7|Stage IV Renal Cell Cancer AJCC v7
Interventions: DRUG: Akt Inhibitor MK2206|DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Statin for Elderly Patients With Atherosclerotic Cardiovascular Disease
Status: COMPLETED
Conditions: Atheroscleroses, Coronary
Interventions: DRUG: Rosuvastatin and Ezetimibe|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regenerative Potential of Cultured Gingival Fibroblast- Mesenchymal Stem Cells in Treatment of Periodontitis
Status: COMPLETED
Conditions: Periodontal Intrabony Defect
Interventions: PROCEDURE: GF+GMSCs carried on β TCP|PROCEDURE: β TCP bone substitute only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acceptance and Commitment Therapy in SSRI-Resistant Obsessive Compulsive Disorder
Status: WITHDRAWN
Conditions: Obsessive-Compulsive Disorder
Interventions: BEHAVIORAL: Acceptance and commitment therapy|DRUG: Aripiprazole|BEHAVIORAL: Stress management training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of a Growth-Mindset Intervention for Adolescents: A Randomised Controlled Trial
Status: COMPLETED
Conditions: Anxiety Disorders and Symptoms|Depression, Anxiety|Adolescent - Emotional Problem
Interventions: OTHER: An Enhanced Psychological Mindset Session for Adolescents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Virtual Reality on Dental Anxiety in Children
Status: COMPLETED
Conditions: Behavior, Child
Interventions: BEHAVIORAL: Distraction by dentist|BEHAVIORAL: Distraction by cartoon movie|BEHAVIORAL: Distraction by virtual reality glasses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prediction of Successful Liberation From Invasive Mechanical Ventilation Via Lung and Diaphragmatic Ultrasound in Intensive Care Unit Patients, Prospective, Observational Study
Status: COMPLETED
Conditions: Liberation From Mechanical Ventilation in ICU Patients
Interventions: OTHER: Sonographic evaluation of diaphragm and lung
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Accelerated Intervention With Compression Sleeve in Mild and Moderate Breast Cancer-related Lymphedema
Status: UNKNOWN
Conditions: Breast Cancer|Lymphedema
Interventions: DEVICE: Custom-made compression sleeve and -gauntlet|OTHER: Educational information, recommendation and instruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NanoMn®_COVID-19 A Prospective, Multicenter, Randomized, Placebo-controlled, Parallel-group, Double-blind Trial to Evaluate the Clinical Efficacy of NanoManganese® on Top of Standard of Care, in Adult Patients With Moderate to Severe Coronavirus Disease 2019 (COVID-19)
Status: TERMINATED
Conditions: COVID-19 Pandemic
Interventions: DRUG: Placebo|DRUG: Experimental drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Sensorimotor and Core Stabilization Exercises After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Osteoarthritis|Arthroplasty|Joint Replacement
Interventions: OTHER: Sensorimotor exercise training|OTHER: Core stabilization exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pain Relieving Effects, Safety, and Tolerability of JNJ-42160443 for the Relief of Bladder Pain
Status: TERMINATED
Conditions: Cystitis, Interstitial|Urologic Diseases|Urinary Bladder Diseases|Cystitis
Interventions: DRUG: Placebo|DRUG: JNJ-42160443
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Study on the Effects of Repeat Doses of Albiglutide Compared to Exenatide on Gastric Myoelectrical Activity and Gastric Emptying in Type 2 Diabetes Mellitus Subjects
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Exenatide|DRUG: Albiglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diindolylmethane in Treating Patients With Stage I or Stage II Prostate Cancer Undergoing Radical Prostatectomy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: B-Dim|PROCEDURE: Radical Prosatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-center Randomized Control Cross-over Study to Evaluate the Safety and Effectiveness of the Dayspring Active Wearable Compression Device vs. an Advanced Pneumatic Compression Device for Treating Breast Cancer Related Lymphedema
Status: UNKNOWN
Conditions: Lymphedema|Lymphedema of Upper Arm|Lymphedema, Breast Cancer
Interventions: DEVICE: Crossover Device (PCD or Dayspring - alternate to first group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Myo-inositol as Adjuvant Therapy in Patients With Polycystic Ovary Syndrome (PCOS) in Vitro Fertilization (IVF)
Status: TERMINATED
Conditions: Polycystic Ovary Syndrome
Interventions: DIETARY_SUPPLEMENT: Inofolic®|OTHER: Gonadotropins; Folic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Single and Repeated Dose Escalation Study of GSK2838232
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: GSK2838232 PIB|DRUG: GSK2838232 IR1|DRUG: GSK2838232 IR2|DRUG: Placebo PIB|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of An Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiation-Based Treatment (Lutetium Lu 177 Dotatate) for Pancreatic Neuroendocrine Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Neuroendocrine Neoplasm
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Lutetium Lu 177 Dotatate|PROCEDURE: Magnetic Resonance Imaging|DRUG: Peposertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of the Use of the New Hemostatic Patch Hemopatch ® in Patients Undergoing Surgical Liver Resection
Status: UNKNOWN
Conditions: Liver Damage|Surgery
Interventions: DEVICE: Hemopatch|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Glyburide (RP-1127) for Traumatic Brain Injury (TBI)
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: DRUG: Glyburide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Using Velcade & Idarubicin in Elderly and Relapsed AML
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia
Interventions: DRUG: Velcade|DRUG: Idarubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Propranolol, a Beta Blocker, Attenuate Stress-Induced Drinking?
Status: RECRUITING
Conditions: Alcohol Drinking
Interventions: DRUG: Propranolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing the Transition From Hospital to Home for Patients With Traumatic Brain Injury and Families
Status: COMPLETED
Conditions: Brain Injuries, Traumatic|Transitional Care|Family Members|Patients
Interventions: BEHAVIORAL: BETTER Transitional Care Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Tarceva (Erlotinib) in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer Who Present EGFR Mutations
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: erlotinib [Tarceva]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relapse Prevention With Varenicline
Status: COMPLETED
Conditions: Recurrence|Smoking Cessation|Substance-Related Disorders
Interventions: DRUG: Varenicline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Volrustomig Priming Regimens Exploratory Phase II Platform Study
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Volrustomig|DRUG: Carboplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of HPV Therapeutic DNA Vaccine (NWRD08) in Patients With Cervical HPV16 and/or HPV18 Positive
Status: RECRUITING
Conditions: HSIL of Cervix
Interventions: BIOLOGICAL: NWRD08
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of the D3 Antagonist GSK598809 on Food Reward and Reinforcement
Status: COMPLETED
Conditions: Substance Dependence
Interventions: DRUG: GSK598809 Capsules|DRUG: GSK598809 Placebo Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Addition of Phytosterols to a Low Phytosterol Diet
Status: COMPLETED
Conditions: Hypercholesterolemia|Coronary Heart Disease
Interventions: DIETARY_SUPPLEMENT: Different amount of phytosterols are added into diets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: FACTS II: A Study to Test the Safety and Effectiveness of a New Medication on the Treatment of Active Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: OPC-6535 Tablets (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: rTMS and Steroid Joint Steroid Injection in Chronic Spinal Pain
Status: RECRUITING
Conditions: Chronic Spinal Pain
Interventions: DEVICE: repetitive transcranial magnetic stimulation|DEVICE: sham repetitive transcranial magnetic stimulation|DRUG: Steroid Joint Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intramuscular Depot Formulation of Aripiprazole as Maintenance Treatment in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Aripiprazole depot 300 or 400 mg|DRUG: Aripiprazole 10-30 mg orally|DRUG: Aripiprazole depot 25 or 50 mg|DRUG: Placebo depot|DRUG: Placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Acarbose on Endothelial Function After a Mixed Meal in Newly Diagnosed Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: acarbose|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: mNGS -Guided Antimicrobial Treatment in Early Severe Community-Acquired Pneumonia Among Immunocompromised Patients
Status: RECRUITING
Conditions: Severe Acute Respiratory Infection|Community-acquired Pneumonia|Respiratory Tract Infections|Pneumonia|Infections
Interventions: OTHER: mNGS-guided treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Model for South Asian Treatment in Diabetes (NaMaSTe-Diabetes) Trial in Primary Care
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Culturally tailored diabetes program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Modified Pectoral Nerve Block Vs Thoracic Erector Spinae Plane Block for Analgesia for Aesthetic Breast Surgeries
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: PROCEDURE: Bilateral Modified Pectoral Nerve Block (PECS II).|PROCEDURE: Bilateral Thoracic Erector spinae plane block (ESPB).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Prospective Evaluation of the Efficacy of Budesonide/Formoterol in Bronchiolitis Obliterans in AHSCT
Status: COMPLETED
Conditions: Obstructive Airway Disease
Interventions: DRUG: Formoterol/Budesonide|DRUG: lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Salivary and Crevicular Protein Concentrations of FIBA, PLMN, HEMO and ApoH in Healthy and Periodontitis Patients
Status: RECRUITING
Conditions: Periodontitis|Periodontal Diseases
Interventions: OTHER: Salivary and crevicular samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Personalized Therapeutic Anti-tumor Vaccine With Pembrolizumab and Standard of Care Chemotherapy in Squamous Non-Small Cell Lung Cancer and Extensive Stage Small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Non Small Cell Lung Cancer|NSCLC|Non-small Cell Lung Cancer|Small Cell Lung Extensive Stage
Interventions: DRUG: Pembrolizumab|BIOLOGICAL: NEO-PV-01 vaccine|PROCEDURE: Biopsy|DRUG: Poly ICLC|PROCEDURE: Leukapheresis|PROCEDURE: Peripheral blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dexmedetomidine on Brachial Plexus Block for Shoulder Surgery
Status: COMPLETED
Conditions: Nerve Pain|Shoulder Pain
Interventions: DRUG: Dexmedetomidine|DRUG: Ropivacaine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Measuring the Effects of Neurostimulation on Risky and Ambiguous Decision-Making Capacity in People With and Without Substance Use Disorder
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder|Healthy Volunteers
Interventions: DEVICE: TMS (MagVenture MagPro 100 with MagOption)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Everolimus-Eluting Versus Zotarolimus-Eluting Sten for Coronary Lesions in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DEVICE: Everolimus eluting stent|DEVICE: Zotarolimus eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of USTRAP™ in Male Urinary Incontinence
Status: RECRUITING
Conditions: Urinary Incontinence
Interventions: DEVICE: Ustrap®|DEVICE: AMS 800®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Accelerated Invisalign Therapy in Conjunction With Acceledent Aura
Status: COMPLETED
Conditions: Malocclusion
Interventions: DEVICE: AcceleDent Aura|DEVICE: Accelerated Invisalign therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety, Tolerability, and Range of Biologically Active Doses of ICM-203 in Mild to Moderate Knee Osteoarthritis
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: GENETIC: ICM-203|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Atlantic Lipid Lowering Treatment Optimization Program
Status: NOT_YET_RECRUITING
Conditions: Familial Hypercholesterolemia|Lipoprotein Types--Lp System Lp(A) Hyperlipoproteinemia|Apolipoprotein B 100, Familial Defective|High Density Lipoprotein Deficiency|Low-Density-Lipoid-Type Hyperlipoproteinemia
Interventions: OTHER: Supportive care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Assess the Long-term Safety of Dupilumab Administered in Participants ≥6 Months to <18 Years of Age With Atopic Dermatitis (AD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: Dupilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: V260 Study: Concomitant Use of V260 and INFANRIX™ Hexa in Healthy Infants (V260-010)
Status: COMPLETED
Conditions: Rotavirus Disease
Interventions: BIOLOGICAL: Rotavirus Vaccine, Live, Oral, Pentavalent|BIOLOGICAL: Comparator: placebo|BIOLOGICAL: Comparator: Infanrix(tm) Hexa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Grading Atrophic Gastritis by Confocal Laser Endomicroscopy Probe (p-CLE)
Status: COMPLETED
Conditions: Atrophic Gastritis
Interventions: OTHER: Cellvizio Viewer software
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Placebo-controlled Study of Maralixibat (SHP625) in Pediatric Subjects With Progressive Familial Intrahepatic Cholestasis (PFIC)
Status: WITHDRAWN
Conditions: Progressive Familial Intrahepatic Cholestasis (PFIC)
Interventions: DRUG: Maralixibat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of and Immune Response to Vaccination With 2 Experimental HIV Vaccines in Healthy Adults
Status: COMPLETED
Conditions: HIV Infection
Interventions: BIOLOGICAL: ALVAC-HIV|BIOLOGICAL: AIDSVAX B/E|BIOLOGICAL: Placebo for ALVAC-HIV|BIOLOGICAL: Placebo for AIDSVAX B/E|BIOLOGICAL: Hepatitis B vaccine|BIOLOGICAL: Tetanus toxoid vaccine|BIOLOGICAL: Placebo for hepatitis B vaccine|BIOLOGICAL: Placebo for tetanus vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of Diclofenac Gel for Breakthrough Pain and the Neuropathic Components of Pain in Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: Diclofenac Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thalidomide and Cyclophosphamide in Treating Children With Recurrent or Refractory Childhood Cancers
Status: COMPLETED
Conditions: Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: cyclophosphamide|DRUG: thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy of Artemether-lumefantrine, Artesunate-amodiaquine and Dihydroartemisinin-piperaquine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Malawi
Status: COMPLETED
Conditions: Malaria, Falciparum
Interventions: DRUG: Artemether-lumefantrine combination|DRUG: Artesunate-amodiaquine combination|DRUG: Dihydroartemisinin-piperaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study to Investigate the Safety, Tolerability and Pharmacokinetic Profile of SNP-630 in Health Subjects.
Status: COMPLETED
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: DRUG: SNP-630
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapy of Adults Affected by Idiopathic Thrombocytopenic Purpura With Dexamethasone
Status: COMPLETED
Conditions: ITP|Croticosteroid Therapy
Interventions: DRUG: High dose Dexamethasone pulses|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pressure-controlled Ventilation-volume Guaranteed Mode
Status: UNKNOWN
Conditions: Anesthesia
Interventions: DEVICE: Group PCV-VG|DEVICE: Group VCV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Home-Based Circuit Training in Overweight/Obese Older Adult Patients With Knee Osteoarthritis and Type 2 Diabetes
Status: COMPLETED
Conditions: Aerobic Exercise|Strength Training|Glycemic Control|Blood Pressure|Oxidative Stress|Metabolic Syndrome
Interventions: BEHAVIORAL: 12-week home-based circuit training (HBCT)|BEHAVIORAL: Standard of care (CONT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Ravulizumab IV in Pediatric Participants With NMOSD
Status: RECRUITING
Conditions: Neuromyelitis Optica Spectrum Disorder
Interventions: DRUG: Ravulizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BOTOX® Treatment in Adult Patients With Post-Stroke Lower Limb Spasticity
Status: COMPLETED
Conditions: Muscle Spasticity
Interventions: BIOLOGICAL: botulinum toxin Type A|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Effects of Roflumilast in (a)MCI and Mild Dementia Patients
Status: UNKNOWN
Conditions: Mild Cognitive Impairment|Mild Dementia|Amnestic Mild Cognitive Disorder
Interventions: DRUG: Roflumilast|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chromium Picolinate for the Treatment of Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome X|Prediabetic State|Insulin Resistance|Obesity|Metabolic Diseases
Interventions: DRUG: Chromium picolinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Isoflurane at Subanesthetic Concentrations - 6
Status: COMPLETED
Conditions: Opioid-Related Disorders|Substance-Related Disorders
Interventions: DRUG: 40% Nitrous oxide|OTHER: Sham comparator|DRUG: 0.2% isoflurane|DRUG: 0.4% isoflurane|DRUG: 0.6% isoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dextran-based Priming vs. Crystalloid and Mannitol-based Priming Solution in Adult Cardiac Surgery
Status: COMPLETED
Conditions: Heart Disease
Interventions: DEVICE: A colloid Dextran 40 solution for extracorporeal circulation|DEVICE: Ringer-Acetate and Mannitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of a Free Distribution of Paracetamol to Osteoarthritic Patients on Non-steroidal Anti-inflammatory Drugs (NSAID) and Proton Pump Inhibitors (PPI) Prescription
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: OTHER: free paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of the Efficacy, Safety and Quality of Life After TOOKAD® Soluble (VTP) for Intermediate Risk Prostate Cancer.
Status: ACTIVE_NOT_RECRUITING
Conditions: Localized Prostate Cancer
Interventions: DRUG: TOOKAD Soluble 4 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Whole Body Vibration Training in Patients With Interstitial Lung Disease
Status: UNKNOWN
Conditions: Interstitial Lung Disease|Scleroderma|Idiopathic Pulmonary Fibrosis
Interventions: OTHER: Whole Body Vibration Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient-Centered Cancer Prevention In Chinese Americans
Status: COMPLETED
Conditions: H. Pylori Infection
Interventions: OTHER: Test-and-treat EHR-CHW intervention|OTHER: Usual care of EHR-only intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Perception of the Doctor/Patient Relationship, Disease and Treatment Among Physicians and Their Patients Treated With Systemic Therapy for Hepatocellular Carcinoma "PERCEPTION1"
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: OTHER: Hospitalized patient with advanced hepatocellular carcinoma receiving systemic therapy.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase II Clinical Trial to Evaluate the Immunogenicity and Safety of SCTV01C in Population Aged ≥18 Years and Previously Fully Vaccinated With COVID-19 Vaccine
Status: UNKNOWN
Conditions: COVID-19|SARS-CoV-2 Infection
Interventions: BIOLOGICAL: SCTV01C|BIOLOGICAL: Sinopharm inactivated COVID-19 vaccine|BIOLOGICAL: Comirnaty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Placebo-controlled Study of 2-day Pre-treatment With Fexofenadine in Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Fexofenadine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Dexmedetomidine in Septic Patients
Status: COMPLETED
Conditions: Sepsis|Agitation
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Sativex® for Pain Relief of Peripheral Neuropathic Pain, Associated With Allodynia
Status: COMPLETED
Conditions: Pain|Peripheral Neuropathy
Interventions: DRUG: Sativex|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Testing an Intergenerational Model of Suicide Risk in Mother-child Dyads
Status: RECRUITING
Conditions: Emotion Regulation
Interventions: BEHAVIORAL: Dialectical Behavior Therapy Skills Group Training|BEHAVIORAL: Safety Planning Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of the ExPRESS Implant Versus Deep Sclerectomy in Combined Surgery
Status: COMPLETED
Conditions: Open Angle Glaucoma|Ocular Hypertension
Interventions: PROCEDURE: Filtration surgery with Ex-PRESS|PROCEDURE: Non penetrating deep sclerectomy|PROCEDURE: Cataract extraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness-based Stress Reduction for Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Mindfulness-based Stress Reduction|BEHAVIORAL: MS Education Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of BMS-354825 in Subjects With CML Who Are Resistant to or Intolerant of Imatinib or Ph+All in Japan
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia
Interventions: DRUG: Dasatinib|DRUG: Dasatinib|DRUG: Dasatinib|DRUG: Dasatinib|DRUG: Dasatinib|DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ability of Grape Seed Proanthocyanidins to Reduce Postprandial Triglycerides in Humans
Status: COMPLETED
Conditions: Triglyceride Metabolism|Cardiovascular Function
Interventions: DIETARY_SUPPLEMENT: 35 mg/Kg of grape seed proanthocyanidins extract (2 capsules)|OTHER: 2 empty capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacokinetic Interaction Study Between Eslicarbazepine Acetate and Carbamazepine
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: BIA 2-093|DRUG: Carbamazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT