pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Muscle Status to Oral Nutritional Supplementation in Hemodialysis Patients With Protein Energy Wasting
Status: COMPLETED
Conditions: Muscle Wasting|End Stage Renal Disease on Dialysis
Interventions: DIETARY_SUPPLEMENT: Oral nutritional supplementation (ONS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of CO2 on Cerebral Blood Flow in Infants Less Than 6 Months During General Anaesthesia
Status: COMPLETED
Conditions: Anesthesia, General|Infant
Interventions: PROCEDURE: EtCO2 modification
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Low Level Laser Therapy for the Treatment of Provoked Vestibulodynia
Status: TERMINATED
Conditions: Provoked Vestibulodynia
Interventions: DEVICE: LOW LEVEL LASER SYSTEM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Therapeutic vs Psychoeducation for Management of Mild to Moderate Depression in Adolescents
Status: COMPLETED
Conditions: Depression, Teen
Interventions: DEVICE: W-GenZD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Jaboticaba (Plinia Cauliflora) Supplementation in Chronic Kidney Disease Patients
Status: NOT_YET_RECRUITING
Conditions: Chronic Kidney Diseases
Interventions: DIETARY_SUPPLEMENT: Jaboticaba Peel Extract|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Body Position on Diaphragmatic Activity in Patients Requiring Noninvasive Ventilation for Acute Respiratory Failure COVID-19 Related
Status: COMPLETED
Conditions: Noninvasive Ventlation|COVID-19 Respiratory Infection|Diaphragm Injury
Interventions: OTHER: Prone position
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase I Study of SHR9146 + SHR-1210 +/- Apatinib in Patients With Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Tumor, Solid|Cancer, Metastatic|Neoplasm Malignant
Interventions: DRUG: SHR9146+SHR-1210|DRUG: SHR9146+SHR-1210+Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Honey or Olive Oil for Treating Oral Mucositis in Children and Adults With Leukemia Receiving Intensive Chemotherapy
Status: COMPLETED
Conditions: Oral Mucositis|Leukemia
Interventions: DIETARY_SUPPLEMENT: Manuka honey|DIETARY_SUPPLEMENT: olive oil|COMBINATION_PRODUCT: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Trial on Nerve Sparing Techniques Performed in Radical Prostatectomy
Status: TERMINATED
Conditions: Prostate Cancer|Quality of Life
Interventions: PROCEDURE: Retzius sparing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Interventions to Resolve Non-alcoholic Steatohepatitis (NASH) With Fibrosis (MIRNA)
Status: COMPLETED
Conditions: Nonalcoholic Fatty Liver Disease|Nonalcoholic Steatohepatitis With Liver Fibrosis
Interventions: DRUG: Placebo|DRUG: PF-06865571|DRUG: PF-05221304
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Pranayama on Pain and Respiration After Coronary Bypass Surgery
Status: COMPLETED
Conditions: Respiratory|Postoperative Pain|Nursing
Interventions: OTHER: Pranamaya|OTHER: Pursed Lips Breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Compare the Efficacy and Safety of Donepezil Hydrochloride 23 mg Treatment With Continuation of Donepezil Hydrochloride 10 mg Treatment in Japanese Subjects With Severe Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Type Dementia
Interventions: DRUG: E2020|DRUG: E2020
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SMMART Adaptive Clinical Treatment (ACT) Trial
Status: WITHDRAWN
Conditions: Advanced Breast Carcinoma|Advanced Malignant Solid Neoplasm|Advanced Ovarian Carcinoma|Advanced Pancreatic Carcinoma|Advanced Prostate Carcinoma|Advanced Sarcoma|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Recurrent Adult Soft Tissue Sarcoma|Recurrent Breast Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Prostate Carcinoma|Stage II Pancreatic Cancer AJCC v8|Stage III Ovarian Cancer AJCC v8|Stage III Pancreatic Cancer AJCC v8|Stage IV Ovarian Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8
Interventions: DRUG: Alectinib|DRUG: Alpelisib|DRUG: Anastrozole|BIOLOGICAL: Atezolizumab|BIOLOGICAL: Bevacizumab|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Capecitabine|DRUG: Carboplatin|DRUG: Cobimetinib|DRUG: Entrectinib|DRUG: Eribulin|DRUG: Fulvestrant|BIOLOGICAL: Hyaluronidase-zzxf/Pertuzumab/Trastuzumab|DRUG: Irinotecan|DRUG: Letrozole|DRUG: Nab-paclitaxel|DRUG: Niraparib|DRUG: Olaparib|DRUG: Paclitaxel|DRUG: Palbociclib|BIOLOGICAL: Pertuzumab|OTHER: Quality-of-Life Assessment|BIOLOGICAL: Trastuzumab|BIOLOGICAL: Trastuzumab Emtansine|DRUG: Vemurafenib|DRUG: Vinorelbine|DRUG: Vismodegib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: South China Children Cancer Group - Relapsed-Acute Lymphoblastic Leukemia 2022 Protocol
Status: RECRUITING
Conditions: Arsenic Trioxide|Childhood ALL
Interventions: DRUG: Realgar Indigo naturalis formula|COMBINATION_PRODUCT: Conventional chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Sedation of Intravenous Administration of HSK3486 Injectable Emulsion in ICU Patients Undergoing Mechanical Ventilation
Status: COMPLETED
Conditions: Sedation in Intensive Care
Interventions: DRUG: HSK3486|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ex Vivo Immunotherapy for Hyperglycemia in Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Hyperglycemia
Interventions: DRUG: ex vivo Activated Immune Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapamycin Use in Calcineurin Inhibitor (CNI)-Free Immunosuppression for Stabilization/Improvement of Renal Function After Heart Transplantation
Status: COMPLETED
Conditions: Heart Transplantation|Renal Failure
Interventions: DRUG: Cyclosporine discontinuation|DRUG: Rapamycin medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Responses to Immunization With Keyhole Limpet Hemocyanin Administered by Scarification and the Intradermal Route
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: BIOLOGICAL: KLH carrier-protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interactive Cholesterol Advisory Tool
Status: COMPLETED
Conditions: Low Risk (0-10% Chance) of Developing Cardiovascular Disease Within 10 Years Based on Risk Factors|Moderate Risk (10-20% Chance) of Developing Cardiovascular (Heart) Disease Within 10 Years Based on Risk Factors
Interventions: OTHER: Interactive Cholesterol Advisory Tool|OTHER: Study physician visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Blinded, Randomized Study Evaluating Aurstat Versus Control in the Treatment of Atopic Dermatitis Associated Pruritus
Status: COMPLETED
Conditions: Pruritus|Atopic Dermatitis
Interventions: DRUG: Aurstat Anti-Itch Hydrogel (Aurstat)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy in Peripheral T Cell Lymphoma - the Role of Alemtuzumab in Addition to Dose Dense CHOP
Status: UNKNOWN
Conditions: Peripheral T Cell Lymphoma, Unspecified|Angioimmunoblastic Lymphadenopathy|Extranodal NK/T-cell Lymphoma
Interventions: BIOLOGICAL: alemtuzumab|DRUG: chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Lithotripsy for Difficult Large Bile Duct Stones
Status: UNKNOWN
Conditions: Sphincterotomy, Endoscopic|Cholangiopancreatography, Endoscopic Retrograde|Lithotripsy, Laser
Interventions: PROCEDURE: dilation-assisted stone extraction|DEVICE: Spyglass Guided Laser Lithotrips
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Retreatment With High Doses of pegIFN Alfa-2a and Ribavirin of Previous Nonresponders HIV-coinfected Patients With Cirrhosis Due to HCV 1-4
Status: COMPLETED
Conditions: Liver Cirrhosis|Hepatitis C Virus|HIV Infection
Interventions: DRUG: Pegylated interferon alfa-2a and Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Neoadjuvant Tislelizumab With SBRT in Patients With Resectable Hepatocellular Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: COMBINATION_PRODUCT: PD-1 plus stereotactic body radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study of 2 mg Alprazolam OD Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ALPRAZOLAM ORALLY DISINTEGRATING TABLETS, 2.0 MG|DRUG: NIRAVAM TM 2 mg orally disintegrating tablets, single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Correction of Head Turn in Idiopathic Infantile Nystagmus
Status: ACTIVE_NOT_RECRUITING
Conditions: Infantile Nystagmus Syndrome
Interventions: PROCEDURE: Graded Anderson procedure|PROCEDURE: Kestenbaum procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study Of Tranexamic Acid For The Reduction Of Blood Loss In Patients Undergoing Major Abdominal Surgery
Status: COMPLETED
Conditions: Biliary Tract Surgical Procedures|Pancreaticoduodenectomy|Esophagectomy|Colectomy|Gastrectomy
Interventions: DRUG: Tranexamic acid + Standard of Care|PROCEDURE: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ATREUS - Phase II Study on the Activity of Trabectedin in Patients With Malignant Pleural Mesothelioma (MPM)
Status: COMPLETED
Conditions: Malignant Pleural Mesothelioma
Interventions: DRUG: Trabectedin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: This Study is Randomised, Single Oral Dose Bioequivalence Study of Meloxicam GSK 15 MG Tablets.
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Meloxicam GSK 15mg|DRUG: Mobic 15mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of DPP-IV Inhibitor in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: DPP-IV Inhibitor|DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study to Assess AFM13 in Patients With R/R CD30-positive T-cell Lymphoma or Transformed Mycosis Fungoides
Status: COMPLETED
Conditions: Peripheral T Cell Lymphoma|Transformed Mycosis Fungoides
Interventions: DRUG: AFM13
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of Depakote Sprinkle Capsules in the Treatment of Partial Seizures in Children
Status: TERMINATED
Conditions: Partial Seizure Disorder
Interventions: DRUG: Divalproex Sodium (Depakote® Sprinkle Capsules)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Bone Marrow-Derived Autologous Stem Cells for the Treatment of Duchenne Muscular Dystrophy
Status: UNKNOWN
Conditions: Duchenne Muscular Dystrophy
Interventions: BIOLOGICAL: Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Navigation Study: Durham
Status: RECRUITING
Conditions: Prenatal; Postnatal
Interventions: BEHAVIORAL: Navigation Intervention Prenatal 1.0 (intervention discontinued, modified to 2.0. Data will not be used)|BEHAVIORAL: Control Intervention|BEHAVIORAL: Navigation Intervention Prenatal 2.0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bioavailability of Iodine in Cow's Milk in Swiss Adults
Status: COMPLETED
Conditions: Iodine Bioavailability
Interventions: DIETARY_SUPPLEMENT: extrinsic iodine in milk|DIETARY_SUPPLEMENT: intrinsic iodine in milk|DIETARY_SUPPLEMENT: water iodine solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multi-center Complex Atrial Tachycardia High-Resolution Mapping Registry (MATH)
Status: WITHDRAWN
Conditions: Atrial Tachycardia (Including Atrial Flutter) Post Atrial Fibrillation Ablation or Cardiac Surgery
Interventions: DEVICE: patient who used Rhythmia system and Orion catheter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multicentric Registry for the Detection of C5 Palsy After Anterior Cervical Discectomy and Fusion
Status: UNKNOWN
Conditions: Degenerative Cervical Spinal Stenosis|Cervical Disc Herniation|Suspected Cervical Spine Instability
Interventions: PROCEDURE: Patients undergo ACDF or cervical vertebral body replacement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Gastrectomy, Eating Behaviour and GLP-1
Status: COMPLETED
Conditions: Gastric Cancer|Dumping Syndrome
Interventions: OTHER: Exendin 9-39|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Retinal Neuro-vascular Coupling in Patients With Neurodegenerative Disease
Status: UNKNOWN
Conditions: Mild Cognitive Impairment|Alzheimer Disease|Healthy
Interventions: DEVICE: DVA|DEVICE: FDOCT|DEVICE: Pattern ERG|DEVICE: Optical Coherence Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ablative Fractional Lasers to Treat Peri-orbital Rhytides
Status: COMPLETED
Conditions: Peri-orbital Rhytides
Interventions: PROCEDURE: Fractional carbon dioxide laser treatment|PROCEDURE: Fractional erbium:YAG laser treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BMS-936558 (MDX-1106) In Subjects With Advanced/Metastatic Clear-Cell Renal Cell Carcinoma (RCC)
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: BIOLOGICAL: nivolumab|BIOLOGICAL: nivolumab|BIOLOGICAL: nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nefopam on Acute Postoperative Pain in Patients Undergoing Orthognathic Surgery
Status: COMPLETED
Conditions: Pain|Orthognathic Surgery
Interventions: DRUG: nefopam|DRUG: normal saline (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dabrafenib + Trametinib + PDR001 In Colorectal Cancer
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Dabrafenib|DRUG: Trametinib|DRUG: PDR001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma
Status: RECRUITING
Conditions: Endometrial Cancer
Interventions: DRUG: Selinexor|DRUG: Matching Placebo for selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Medication Adherence and Use of Inhaler Devices in Patients With Asthma or COPD
Status: COMPLETED
Conditions: Asthma COPD
Interventions: BEHAVIORAL: Patient education and counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phacotrabeculotomy Versus CCI+Phaco in Patients With Borderline Control of Intraocular Pressure
Status: TERMINATED
Conditions: Primary Open Angle Glaucoma|Pseudoexfoliative Glaucoma
Interventions: PROCEDURE: Phacoemulsification, implantation of intraocular lens|PROCEDURE: Phacoemulsification, Implantation of IOL, trabeculotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can we Achieve 'High-quality' Weight Loss Through Supplementation and Exercise? The TRIM MUSCLE Study
Status: RECRUITING
Conditions: Overweight|Obesity
Interventions: DIETARY_SUPPLEMENT: Muscle5 and TRIM7|OTHER: Mixed exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy Study of Thymoglobulin Versus IL2 Receptor Antagonists
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DRUG: Rabbit Antithymocyte globulin|DRUG: Daclizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Investigating Safety, Tolerability, PK and PD for Multiple Doses of NNC9204-0530 in Combination With Liraglutide in Male and Female Subjects Being Overweight or With Obesity
Status: COMPLETED
Conditions: Metabolism and Nutrition Disorder|Obesity
Interventions: DRUG: NNC9204-0530|DRUG: liraglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Flax Muffins and Cholesterol Lowering
Status: ACTIVE_NOT_RECRUITING
Conditions: Above Optimal Plasma LDL Concentrations
Interventions: OTHER: muffin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sexual Dysfunction in Gynecologic Oncology Patients
Status: TERMINATED
Conditions: Gynecologic Cancer|Sexual Dysfunction
Interventions: DRUG: Lidocaine Topical|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: RCT Study of Levosimendan Improving Prognosis of Cardiac Arrest
Status: NOT_YET_RECRUITING
Conditions: Heart Arrest
Interventions: DRUG: Levosimendan Injection|DRUG: physiological saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pembrolizumab (MK-3475) for First Line Treatment of Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck (MK-3475-048/KEYNOTE-048)
Status: COMPLETED
Conditions: Recurrent Head and Neck Cancer|Metastatic Head and Neck Cancer
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: 5-FU|BIOLOGICAL: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Large Pragmatic Cluster Randomized Controlled Trial of a Multi-element Psychosocial Intervention for Early Psychosis
Status: COMPLETED
Conditions: Psychosis
Interventions: OTHER: Treatment As Usual (TAU)|BEHAVIORAL: TAU+CBT for pts+Family Intervention+CM.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Role of Brentuximab Vedotin as Single Agent in the Treatment of Relapsed/Refractory CD30+ PTCL Patients
Status: COMPLETED
Conditions: Lymphatic Diseases
Interventions: DRUG: Brentuximab Vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Avelumab Plus Chemotherapy in the Peri-operative Treatment for Patients With Resectable Gastric Cancer (GC) or Gastroesophageal Junction Cancer (GEJC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastroesophageal Junction Adenocarcinoma|Stomach Neoplasms
Interventions: COMBINATION_PRODUCT: Avelumab addition to perioperative chemotherapy in GC and GEJC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK Study of Ticagrelor in Children Aged Less Than 24 Months, With Sickle Cell Disease (HESTIA4)
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Are Elastic Restraints Still Necessary in Improved Rehabilitation Programs After Hip and Knee Prosthetic Surgery?
Status: NOT_YET_RECRUITING
Conditions: Arthroplasty Complications
Interventions: PROCEDURE: Pharmacological thromboprophylaxis and elastic compression|PROCEDURE: Pharmacological thromboprophylaxis without elastic compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Open-Label, Long-term Balsalziade Disodium Tablet Ulcerative Colitis Study
Status: COMPLETED
Conditions: Inflammatory Bowel Disease|Ulcerative Colitis
Interventions: DRUG: Balsalazide Disodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: NESA Microcurrents on Quality of Life in Geriatric Patients
Status: COMPLETED
Conditions: Aging
Interventions: DEVICE: Non-invasive neuromodulation through the Nesa device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Ethanol Alcohol Injection for the Large and Unresectable Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma Non-resectable
Interventions: PROCEDURE: Percutaneous ethanol alcohol injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Transplantation For Severe Osteopetrosis
Status: COMPLETED
Conditions: Severe Osteopetrosis
Interventions: PROCEDURE: umbilical cord blood transplantation|DRUG: Campath-1H|RADIATION: Total Lymphoid Irradiation|DRUG: Cyclophosphamide|DRUG: Busulfan|DRUG: Fludarabine monophosphate|PROCEDURE: marrow graft transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of DIT112 in the Treatment of Moderate to Severe Pain After Dental Surgery for the Extraction of Impacted Third Molars
Status: NOT_YET_RECRUITING
Conditions: Moderate Pain|Severe Pain
Interventions: DRUG: DIT112|DRUG: DIPYRONE|DRUG: TRAMADOL|DRUG: DIT112 Placebo|DRUG: Dipyrone Placebo|DRUG: Tramadol Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of Gene Therapy Drug in the Treatment of Spinal Muscular Atrophy (SMA) Type 3 Patients
Status: RECRUITING
Conditions: Spinal Muscular Atrophy Type 3
Interventions: GENETIC: GC101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Perioperative Ventilation (Gas Exchange) During Intrabdominal Surgery on Cognitive Function
Status: COMPLETED
Conditions: Response to Hyperoxia|Hypocapnia
Interventions: PROCEDURE: mechanical ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sacubitril/Valsartan in PriMAry preventIoN of the Cardiotoxicity of Systematic breaST canceR trEAtMent (MAINSTREAM)
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Neoplasm, Breast|Breast Diseases|Antihypertensive Agents|Sacubitril/Valsartan|Angiotensin II Type 1 Receptor Blockers|Angiotensin Receptor Antagonists|Molecular Mechanisms of Pharmacological Action|Heart Failure|Cardiac Toxicity|Cancer, Therapy-Related|Cancer Therapy-Related Cardiac Dysfunction|Cardiotoxicity
Interventions: DRUG: Sacubitril-valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Low Sodium Diet on Idiopathic Hyperaldosteronism
Status: COMPLETED
Conditions: Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
Interventions: DIETARY_SUPPLEMENT: Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caring for Providers to Improve Patient Experience Study Phase 2 in Migori County
Status: COMPLETED
Conditions: Maternal Health|Mental Health|Healthcare Provider|Adverse Outcomes|Stress|Stress, Psychological|Stress, Emotional|Quality of Care|Burnout|Discrimination, Social
Interventions: BEHAVIORAL: Training|BEHAVIORAL: Peer support and mentorship|BEHAVIORAL: Leadership engagement|BEHAVIORAL: Embedded champions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bevacizumab/Ph 2 for Locally Advanced Head and Neck Cancer
Status: COMPLETED
Conditions: Carcinoma, Squamous Cell of Head and Neck
Interventions: DRUG: Docetaxel, Cisplatin, Cetuximab and Bevacizumab (TPE-A) Followed by Concurrent Radiation, Cisplatin, Cetuximab and Bevacizumab (XPE-A), surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Video vs. TTG Respiratory Inhaler Technique Assessment and InstructioN (V-TRaIN)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Asthma
Interventions: BEHAVIORAL: Video Module Education (VME)|BEHAVIORAL: Teach-To-Goal (TTG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study To Investigate The Drug-Drug Interaction Potential Of Rifampin OnThe Investigational Agent Palbociclib (PD-0332991)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Palbociclib|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Iodine I 131 Tositumomab Followed by Autologous Stem Cell Transplantation in Treating Older Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: sargramostim|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: tositumomab and iodine I 131 tositumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Radiation Therapy for Sarcomas
Status: COMPLETED
Conditions: Soft Tissue Sarcoma|Fibrous Histiocytoma|Liposarcoma|Leiomyosarcoma|Fibrosarcoma|Synovial Sarcoma
Interventions: DRUG: Bevacizumab|RADIATION: Radiation Therapy|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain and Magnesium
Status: UNKNOWN
Conditions: Neuropathic Pain Induced by Mastectomy
Interventions: DRUG: Magnesium: Magnésium UPSA Action Continue®|DRUG: Placebo: Lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Physiological and Functional Effects of Percutaneous Neuromodulation vs Transcutaneous Neuromodulation
Status: ACTIVE_NOT_RECRUITING
Conditions: Stroke/Brain Attack
Interventions: DEVICE: Percutaneous neuromodulation|DEVICE: Transcutaneous neuromodulation|DEVICE: Placebo-percutaneous|DEVICE: Placebo-transcutaneous|DEVICE: Percutaneous neuromodulation or Transcutaneous neuromodulation (optional)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cabozantinib +/- Trastuzumab In Breast Cancer Patients w/ Brain Metastases
Status: COMPLETED
Conditions: Breast Cancer|Brain Tumor - Metastatic
Interventions: DRUG: Cabozantinib|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adoptive Cell Therapy Following Non-myeloablate Chemotherapy in Metastatic Melanoma Patients
Status: UNKNOWN
Conditions: Metastatic Melanoma
Interventions: PROCEDURE: Procedure - Adoptive cell transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Australia and New Zealand Multicentre Upper Gastrointestinal Endoscopic Tissue Resection Study
Status: RECRUITING
Conditions: Cancer of Stomach|Oesophageal Cancer|Gastric Cancer|Gastric Adenocarcinoma|GI Cancer|GIST|Neuroendocrine Tumors|Gastric Neoplasm|Esophageal Neoplasms
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Community Salt Testing and Relation of Iodine Intake to Visual Information Processing of Ethiopian Infants
Status: COMPLETED
Conditions: Iodine Deficiency Goiter|Infant Development
Interventions: DIETARY_SUPPLEMENT: Iodine capsule|OTHER: Iodized Salt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile Health Program for Rural Hypertension
Status: RECRUITING
Conditions: Hypertension,Essential|Adherence, Medication|Quality of Life
Interventions: BEHAVIORAL: Coaching application|OTHER: WebMD|BEHAVIORAL: Home-based blood pressure monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability of MEDI-565 in Adults With Gastrointestinal Adenocarcinomas
Status: COMPLETED
Conditions: Gastrointestinal Adenocarcinomas
Interventions: DRUG: MEDI-565|DRUG: MEDI-565|DRUG: MEDI-565|DRUG: MEDI-565
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concurrent Neoadjuvant Chemoradiotherapy Plus Trastuzumab in the Treatment of Siewert II ，III of Human Epidermal Growth Factor Receptor-2(HER-2) Positive Gastroesophageal Junction Adenocarcinoma： A Randomized, Controlled Clinical Study
Status: UNKNOWN
Conditions: Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Trastuzumab|DRUG: Capecitabine|DRUG: Oxaliplatin|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prairie Loin Pain Hematuria Syndrome Renal Denervation Study: A Feasibility Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Loin Pain-Hematuria Syndrome
Interventions: DEVICE: Symplicity Spyral™ multi electrode renal denervation system|DIAGNOSTIC_TEST: Renal angiogram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Steroid Injections and Platelet Rich Plasma Injections in the Treatment of Plantar Fasciitis
Status: WITHDRAWN
Conditions: Plantar Fasciitis
Interventions: DRUG: Corticosteroid injection (Bupivacaine and Depo Medrol)|BIOLOGICAL: Platelet rich plasma injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Sildenafil to Treat Newborns With Persistent Pulmonary Hypertension
Status: TERMINATED
Conditions: Persistent Pulmonary Hypertension|Respiratory Failure
Interventions: DRUG: Intravenous Sildenafil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vasopressin Versus Norepinephrine for the Management of Shock After Cardiac Surgery
Status: UNKNOWN
Conditions: Shock
Interventions: DRUG: Vasopressin|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BLI1100 for the Treatment of Moderate to Severe Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: BLI1100|DRUG: Vehicle cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Psychosocial, Environmental, and Chronic Disease Trends in Puerto Rico
Status: RECRUITING
Conditions: Heart Diseases|Type2 Diabetes|Hypertension|Obesity|Dyslipidemias|Metabolic Syndrome|Cardiovascular Diseases|Chronic Disease|Inflammation|Psychological Stress|Physiological Stress|Depressive Symptoms|Coping Behavior|Diet Habit|Lifestyle
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinic to Community Navigation to Improve Diabetes Outcomes
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: BEHAVIORAL: Diabetes Self-Management Program (DSMP)|BEHAVIORAL: Tailored Patient Navigation (PN) only|BEHAVIORAL: DSMP AND Tailored Patient Navigation|BEHAVIORAL: Diabetes Self-Management Program (DSMP) Delayed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study Between a Pre-hospital and an In-hospital Circulatory Support Strategy (ECMO) in Refractory Cardiac Arrest (APACAR2)
Status: COMPLETED
Conditions: Cardiac Arrest|Sudden Death
Interventions: OTHER: ECMO Insertion on pre hospital setting|OTHER: In Hospital ECMO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Efficacy of Self-Driven Repetitive Artmaking Practice
Status: RECRUITING
Conditions: Chronic Pain|Opioid Use Disorder|Opioid Misuse|Opioid-Related Disorders
Interventions: BEHAVIORAL: Self-Driven Repetitive Artmaking
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Pharmacokinetics (Drug Levels and Metabolism), Safety, and Tolerability of BMS-986259 in Participants With Various Levels of Kidney Function
Status: COMPLETED
Conditions: Renal Failure
Interventions: DRUG: BMS-986259
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transition to Scale of Nutrition and Psychosocial Stimulation Program for Malnourished Children
Status: COMPLETED
Conditions: Moderate and Severe Undernutrition
Interventions: BEHAVIORAL: Psychosocial Stimulation and Nutritional Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Symptomatic Treatment of Excessive Dynamic Airway Collapse Using Daytime Portable Continuous Positive Airway Pressure
Status: COMPLETED
Conditions: Excessive Dynamic Airway Collapse|Tracheobronchomalacia
Interventions: OTHER: Experimental: Treatment|OTHER: Experimental: Run In Phase|OTHER: Sham Comparator: Stand Care Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OCP vs Metformin for Improvement in Clinical Symptoms and Metabolic Markers in Indian PCOS Women
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Oral contraceptive pill combination of ethyl estradiol and Cyproterone acetate|DRUG: Metformin 1500mgs per day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine + Carboplatin + Nivolumab Versus Gemcitabine + Oxaliplatin + Nivolumab in Cisplatin-ineligible Patients With Metastatic Urothelial Cancer
Status: COMPLETED
Conditions: Metastatic Urothelial Cancer
Interventions: DRUG: Nivolumab|DRUG: Gemcitabine|DRUG: Carboplatin|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influenza Viral Challenge Study of CC-42344 in Healthy Participants
Status: RECRUITING
Conditions: Influenza A
Interventions: DRUG: CC-42344|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nutritive Effects of Cow's Milk-Based Formulas Through 18 Months of Age
Status: TERMINATED
Conditions: Nutritive Effects on Brain Myelination
Interventions: OTHER: Control|OTHER: Investigational
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Impact of Oxygen Therapy on Fatigue in Patients With Hypermobile-type Ehlers-Danlos Syndrome
Status: UNKNOWN
Conditions: Ehlers-Danlos Syndrome
Interventions: DRUG: Oxygen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing Effects of Beetroot Juice and Mediterranean Diet on Liver Enzymes and Sonography in Patients With NAFLD
Status: COMPLETED
Conditions: NAFLD, Non-alcoholic Fatty Liver Disease
Interventions: OTHER: Beetroot juice|OTHER: placebo|OTHER: Mediterranean diet alone (MeD)|COMBINATION_PRODUCT: Mediterranean diet with beet juice (BJ+MeD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Observational Study to Evaluate Fluid Resolution and Effectiveness in Patients Receiving Beovu in Neovascular Age-related Macular Degeneration and Visual Impairment Due to Diabetic Macular Edema
Status: ACTIVE_NOT_RECRUITING
Conditions: Neovascular Age-related Macular Degeneration (nAMD)|Diabetic Macular Edema (DME)
Interventions: DRUG: brolucizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Intra-subject Phaco/Trabectome vs. Phaco/Kahook Dual Blade on Intraocular Pressure
Status: COMPLETED
Conditions: Glaucoma
Interventions: PROCEDURE: KDB/Phacoemulsification|PROCEDURE: Trabectome/Phacoemulsification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeting Acute Congestion With Tolvaptan in Congestive Heart Failure
Status: COMPLETED
Conditions: Heart Failure|Dyspnea
Interventions: DRUG: Tolvaptan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacodynamics of RDX5791 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: RDX5791|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety Profile of Cisatracurium Besylate for IAH
Status: UNKNOWN
Conditions: Intra-abdominal Hypertension
Interventions: DRUG: Cisatracurium Besylate|DRUG: saline 0.12ml/kg/hr
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety and Effectiveness of Arbaclofen Extended-Release Tablets for Patients With MS
Status: COMPLETED
Conditions: Multiple Sclerosis|Spasticity, Muscle
Interventions: DRUG: Arbaclofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intensive Group Based CIMT for Young Children
Status: COMPLETED
Conditions: Hemiplegic Cerebral Palsy|Non-Accidental Traumatic Head Injury to Child
Interventions: OTHER: Intensive, Group Based Constraint Induced Therapy (CIMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alterations in Bioelectric Activity at Acupuncture Points Following CV4 Cranial Manipulation
Status: COMPLETED
Conditions: Autonomic Imbalance
Interventions: OTHER: Osteopathic cranial manipulative medicine|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Comparing MTA Pulpotomy to Root Canal Treatment in Management of Permanent Molars With Irreversible Pulpitis in Children
Status: NOT_YET_RECRUITING
Conditions: Irreversible Pulpitis
Interventions: PROCEDURE: MTA Pulpotomy|PROCEDURE: Root Canal Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Pharmacokinetics and Safety of Onartuzumab (MetMAb) in Chinese Patients With Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: 4 mg/kg Onartuzumab (MetMAb)|DRUG: 15 mg/kg Onartuzumab (MetMAb)|DRUG: 30 mg/kg Onartuzumab (MetMAb)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study in Healthy Volunteers to Investigate the Neurocognitive Effects of a New Antiepileptic Drug: Brivaracetam
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Brivaracetam|DRUG: levetiracetam|DRUG: lorazepam|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Propranolol Treatment to Prevent Melanoma Progression
Status: SUSPENDED
Conditions: Stages III Skin Melanoma|Stages II Skin Melanoma|Stage IB Skin Melanoma
Interventions: DRUG: Propranolol hydrochloride|DRUG: Placebo pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Multi-parametric MRI in Patients Suspected for Muscle Invasive Bladder Cancer: a New Local Staging Paradigm
Status: RECRUITING
Conditions: Bladder Cancer
Interventions: DIAGNOSTIC_TEST: mpMRI plus a same-day cystoscopic bladder biopsy|PROCEDURE: TURBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cognitive Behavioral Strategies and Transcranial Magnetic Stimulation in Obsessive-Compulsive Disorder: Open Label Study
Status: TERMINATED
Conditions: Obsessive Compulsive Disorder (OCD)
Interventions: DEVICE: Transcranial magnetic stimulation|BEHAVIORAL: Cognitive behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Assessment of a Syringe Pump to Pre-eclamptic Women in a Low-resource Hospital
Status: COMPLETED
Conditions: Pre-eclampsia
Interventions: OTHER: Saline|DRUG: Magnesium Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety, Tolerability, PK, PK-PD Relation of KD101 in the Fed State in Obese or Overweight Subjects
Status: UNKNOWN
Conditions: Obesity
Interventions: DRUG: KD101|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: