pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Carelizumab Combined With Regorafenib in the Treatment of HCC（CARE-2020）
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Regorafenib Pill&Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interleukin-2 in Treating Children With Stage IV Neuroblastoma Who Have Received Induction Therapy and Peripheral Stem Cell Transplantation
Status: UNKNOWN
Conditions: Neuroblastoma
Interventions: BIOLOGICAL: aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Third-line Therapy of Multiple Myeloma a Prospective Phase I /II Trial
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Lenalidomide, Pioglitazone, dexamethasone, treosulfan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oblimersen and Dacarbazine in Treating Patients With Advanced Malignant Melanoma That Has Responded to Treatment on Clinical Trial GENTA-GM301
Status: UNKNOWN
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: oblimersen sodium|DRUG: dacarbazine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Ischaemic-Reperfusion and Ischaemic Preconditioning on the Endogenous Fibrinolysis in Man
Status: COMPLETED
Conditions: Ischaemic Heart Diseases
Interventions: PROCEDURE: Forearm vascular study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Daunorubicin or Idarubicin With Cytarabine Plus Quizartinib vs Physician's Choice in Newly Diagnosed FLT3-ITD+ AML
Status: WITHDRAWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Quizartinib|DRUG: Treatment according to Physician's Choice|DRUG: Standard of Care Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid P2Y12 Receptor Inhibition Attenuates Inflammatory Cell Infiltration in Thrombus Aspirated From the STEMI Patients
Status: COMPLETED
Conditions: Inflammation|Thrombosis
Interventions: DRUG: ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of S 95005 in Combination With Oxaliplatin in Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Trifluridine/tipiracil hydrochloride (S 95005)|DRUG: Oxaliplatin|DRUG: Bevacizumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Stingless Bee Honey Mouthrinse on Dental Plaque Accumulation
Status: COMPLETED
Conditions: Plaque Accumulation|Patient Acceptance
Interventions: OTHER: Stingless bee honey mouthrinse|OTHER: normal saline mouthrinse|OTHER: chlorhexidine mouthrinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prevention of Contrast Induced Nephropathy (NIC) by Intravenous Versus Oral Rehydration
Status: COMPLETED
Conditions: KIDNEY FAILURE, ACUTE
Interventions: OTHER: Intravenous hydration with bicarbonate|OTHER: Oral hydration with Sodium solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ibrutinib and Acalabrutinib Use and Risk of Atrial Fibrillation in Patients With Chronic B-cell Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic B-cell Malignancies|BTK Inhibitors|Cardiovascular Diseases
Interventions: DRUG: BTK inhibitor (Ibrutinib or Acalabrutinib)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Decreasing Delirium Through Music
Status: COMPLETED
Conditions: Delirium
Interventions: OTHER: Music Therapy - Personalized Playlist|OTHER: Music Therapy - Standard Playlist|OTHER: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optimization of Cyclosporin in Atopic Dermatitis Through Multiomic Predictive Models of Treatment Response
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: Cyclosporin A|OTHER: Follow-up of Cyclospoin treatment already started
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Achilles Tendon Elongation and Gait Pattern After Rupture.
Status: COMPLETED
Conditions: Achilles Tendon Rupture
Interventions: PROCEDURE: Individualized treatment of Acute Achilles tendon rupture.|PROCEDURE: Non-operative treatment|PROCEDURE: Operative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of TrueVision System: LRI and Capsulorhexis Templates
Status: COMPLETED
Conditions: Subjects Undergoing Cataract Surgery and Insertion of IOL
Interventions: DEVICE: TrueVision 3D Visualization and Guidance System for MicroSurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Montage-Enhanced Sternal Closure
Status: UNKNOWN
Conditions: Sternal Closure
Interventions: DEVICE: Montage bone putty|OTHER: Conventional Sternal Closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Clinical Study of Thalidomide in the Treatment of Ankylosing Spondylitis
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: DRUG: Thalidomide 150mg|DRUG: Thalidomide 100mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effects of Transcranial Direct Current Stimulation to Different Brain Regions on Ankle Tracking Motor Learning, Motor Adaptation, and Brain Connectivity in Healthy Middle-aged and Older Adults and Patients With Subcortical Stroke
Status: RECRUITING
Conditions: Transcranial Direct Current Stimulation|Ankle|Motor Learning|Adaptation|Brain Structure|Brain Connectivity|Stroke
Interventions: OTHER: cM1 transcranial direct current stimulation|OTHER: cPPC transcranial direct current stimulation|OTHER: iCBM transcranial direct current stimulation|OTHER: sham transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Efficacy and Safety of PT20 in Subjects With Hyperphosphataemia and Dialysis Dependent Chronic Kidney Disease
Status: COMPLETED
Conditions: Hyperphosphataemia
Interventions: DRUG: PT20|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Additive Effects of Including Canines in Regulating Together
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Emotion Regulation
Interventions: BEHAVIORAL: Regulating Together-Canine|BEHAVIORAL: Regulating Together-Standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Rehabilitation Programs Based on Eccentric Exercise of Knee Extensor Muscles in Isotonic and Isokinetic Conditions After Anterior Cruciate Ligament Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injury
Interventions: OTHER: Isokinetic eccentric exercises|OTHER: Isotonic eccentric exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cryoablation vs Lumpectomy in T1 Breast Cancers
Status: RECRUITING
Conditions: Breast Cancer|Breast Neoplasm
Interventions: DEVICE: Endocare SlimLine Cryoprobe|PROCEDURE: Lumpectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Controlled Randomized Vagus Nerve Stimulation (VNS) Therapy Versus Resection (CoRaVNStiR)
Status: UNKNOWN
Conditions: Epilepsy
Interventions: PROCEDURE: Vagus nerve stimulation therapy|PROCEDURE: Resective surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: GH21 Capsules for Advanced Solid Tumors: A Study on Safety and Early Results
Status: RECRUITING
Conditions: Advanced Solid Tumor|Non-Small Cell Lung Cancer|Pancreatic Cancer|Colorectal Cancer|Head and Neck Neoplasm
Interventions: DRUG: GH21 Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Zolpidem-MR Administered Over a Long Term Period as Needed for Insomnia (ZOLONG)
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders
Interventions: DRUG: zolpidem-MR (SL800750)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Baseline Follicle Stimulating Hormone, Ovarian Volume and Antral Follicle Count as Prognostic Factors of the Outcome of In-vitro Fertilisation/Intracytosolic Sperm Injection in Infertile Patients Receiving Gonal f for Controlled Ovarian Hyperstimulation
Status: COMPLETED
Conditions: Infertility
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Therapeutic Effect of Cytoreductive Radical Prostatectomy in Men With Newly Diagnosed Metastatic Prostate Cancer
Status: RECRUITING
Conditions: Stage IV Prostate Adenocarcinoma AJCC v7
Interventions: DRUG: Antiandrogen Therapy|DRUG: Docetaxel|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Radical Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of RX-10045 Ophthalmic Solution for Ocular Inflammation and Pain in Cataract Surgery
Status: COMPLETED
Conditions: Inflammation|Pain|Cataract
Interventions: DRUG: RX-10045
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Find the Highest Safe Dose of Soluble Guanylate Cyclase (sGC) Activator, BAY 1211163 Administered as Multiple Doses by Inhalation to Patients Who Cannot Breathe by Their Own and Suffer From a Type of Lung Failure That Causes Fluid to Build up in the Lungs Making Breathing Difficult (ARDS)
Status: TERMINATED
Conditions: Acute Respiratory Distress Syndrome
Interventions: DRUG: BAY1211163
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of Patient Reported Outcome Measures in Participants With Nontuberculous Mycobacterial Lung Infection Caused by Mycobacterium Avium Complex
Status: COMPLETED
Conditions: Mycobacterium Infections, Nontuberculous
Interventions: DRUG: ALIS|DRUG: Azithromycin|DRUG: Ethambutol|DRUG: ELC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Licorice Botanical Dietary Supplements - Metabolism and Safety in Women
Status: COMPLETED
Conditions: Food-drug Interaction
Interventions: DIETARY_SUPPLEMENT: Licorice|DRUG: Alprazolam 2 MG|DRUG: Caffeine 100 MG|DRUG: Tolbutamide 250 mg|DRUG: Dextromethorphan 30mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Renal Denervation Therapy in Hypertensive Patients Undergoing A-Fib Ablation
Status: TERMINATED
Conditions: Atrial Fibrillation|Hypertension
Interventions: PROCEDURE: AF ablation with Renal Denervation|PROCEDURE: AF ablation alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Trial of Nivolumab With Neoadjuvant CF or DCF Therapy for Locally Advanced Esophageal Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Esophageal Squamous Cell Carcinoma
Interventions: BIOLOGICAL: Nivolumab|DRUG: 5-FU|DRUG: CDDP|DRUG: DTX
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strength Training Using Neuromuscular Electrical Stimulation For Children With Cerebral Palsy
Status: UNKNOWN
Conditions: Spastic Diplegic Cerebral Palsy
Interventions: DEVICE: NMES Strength Training|OTHER: Volitional Strength Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early High-Dose Vitamin D and Residual β-Cell Function in Pediatric Type 1 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Type 1 Diabetes
Interventions: DRUG: Cholecalciferol (Vit D3) 400Unit Cap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Inspiratory Muscular Training (IMT) on Diaphragmatic Mobility in Morbidly Obese
Status: COMPLETED
Conditions: Obesity
Interventions: DEVICE: Threshold|DEVICE: Sham Threshold
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase I Clinical Study to Investigate the Pharmacokinetics and Safety/Tolerability of DA-7218 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: DA-7218|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Coordinated Parent/Child Dyad Weight Loss Intervention: Dyad Plus (Feasibility)
Status: COMPLETED
Conditions: Weight Loss|Pediatric Obesity
Interventions: BEHAVIORAL: Brenner FIT|BEHAVIORAL: By Design|BEHAVIORAL: Coordination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Pharmacokinetic Profiles of Two Nicotine Gum Formulations
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Nicotine (2 mg)|DRUG: Nicotine (4 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Kinetics and Repeatability of 18F-BMS-986327
Status: COMPLETED
Conditions: Healthy Participants|Idiopathic Pulmonary Fibrosis (IPF)
Interventions: DIAGNOSTIC_TEST: 18F-BMS-986327
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: KALETRA Or LEXIVA With Ritonavir Combined With EPIVIR And Abacavir In Naive Subjects Over 48 Weeks
Status: COMPLETED
Conditions: HIV Infection|Infection, Human Immunodeficiency Virus
Interventions: DRUG: LEXIVA (GW433908)|DRUG: Ritonavir|DRUG: KALETRA|DRUG: EPIVIR|DRUG: Ziagen|DRUG: Abacavir/Lamivudine|DRUG: Fosamprenavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Intensity Interval Training vs Moderate Intensity and Continuous Training in Chronic Heart Failure
Status: COMPLETED
Conditions: Chronic Heart Failure
Interventions: BEHAVIORAL: exercise training in heart failure with HIIT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Theta Burst Stimulation Plus Habit Override Training for Compulsive Behaviors
Status: RECRUITING
Conditions: Compulsive Behavior|Obsessive-Compulsive Disorder
Interventions: BEHAVIORAL: Habit Override Practice|DEVICE: Transcranial Magnetic Stimulation|BEHAVIORAL: Sham Training|DEVICE: Sham Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized, Double-blind Study to Assess the Efficacy and Safety of α-lipoic Acid Versus BK-C-0701 in Subjects With Diabetic Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathies
Interventions: DRUG: BK-C-0701
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive and Behavioral Intervention for the Management of Episodic Breathlessness in Patients With Advanced Disease
Status: COMPLETED
Conditions: Dyspnea|Respiratory Insufficiency|Neoplasms|Pulmonary Disease, Chronic Obstructive|Lung Diseases|Heart Failure|Lung Diseases, Interstitial|Palliative Care|Palliative Medicine|Breathlessness
Interventions: BEHAVIORAL: Cognitive and Behavioral intervention for the Management of Episodic Breathlessness
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Accelerometer Use in the Prevention of Exercise-Associated Hypoglycemia in Type 1 Diabetes: Outpatient Exercise Protocol
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: Computer algorithm to initiate pump suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Decentralized Clinical Trial in Men and Pre and Post-menopausal Women With Breast Cancer and a Specific Mutation (PIK3CA) Treated With Alpelisib in Combination With Fulvestrant
Status: TERMINATED
Conditions: Advanced Breast Cancer
Interventions: DRUG: Alpelisib|DRUG: Fulvestrant|DRUG: Goserelin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of SGLT2i in noHCM With HFpEF
Status: RECRUITING
Conditions: Hypertrophic Cardiomyopathy|Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: Empagliflozin 10 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TACE Combined With Atezolizumab Plus Bevacizumab or TACE Alone in Patients With Untreated Heaptocellular Carcionma
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Atezolizumab|DRUG: Becavizumab|DEVICE: Transarterial chemoembolization (TACE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Annamycin in Children and Young Adults With Refractory or Relapsed ALL or AML
Status: TERMINATED
Conditions: Acute Lymphocytic Leukemia|Acute Myelogenous Leukemia
Interventions: DRUG: Liposomal Annamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Study - Phase 3b MenB Long Term Persistence in Adolescents
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: rMenB+OMV NZ (Meningococcal (Group B) multi component recombinant adsorbed vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Particulate Matter, Blood Pressure, and the Sympathetic Nervous System
Status: COMPLETED
Conditions: Air Pollution
Interventions: OTHER: exposure to particulate matter with N 95 facemask|OTHER: exposure to particulate matter with no face mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Obicetrapib and Obicetrapib Plus Repatha on Lp(a) Levels
Status: NOT_YET_RECRUITING
Conditions: Dyslipidemias
Interventions: DRUG: obicetrapib 10 mg + obicetrapib/evolocumab 140 mg Q 2 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Austrian Registry for Evaluation of Treatment Patterns and Outcome in Patients With Advanced Pancreatic Ductal Adenocarcinoma (PDAC)
Status: RECRUITING
Conditions: Pancreatic Cancer|Advanced Pancreatic Carcinoma
Interventions: DRUG: all approved chemotherapeutic agents from second line
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neoadjuvant Cabozantinib in Treating Patients With Locally Advanced Kidney Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Clear Cell Renal Cell Carcinoma|Renal Cell Carcinoma|Stage III Renal Cell Cancer AJCC v8
Interventions: DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Study of Surgery vs No Surgery in Patients With Mild Asymptomatic Primary Hyperparathyroidism
Status: COMPLETED
Conditions: Hyperparathyroidism
Interventions: PROCEDURE: parathyroidectomy|OTHER: Observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Clofarabine in Older Patients With Acute Myeloid Leukemia (AML) for Whom Chemotherapy Is Not Suitable
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-procedural Pain Associated With 5 Versus 20 Intravesical Injections of Onabotulinumtoxin A
Status: RECRUITING
Conditions: Urinary Bladder, Overactive|Incontinence, Urge|Incontinence, Urinary|Urinary Urge Incontinence|Urinary Frequency More Than Once at Night|Nocturia
Interventions: DRUG: OnabotulinumtoxinA 100 UNT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Proof of Concept Study for a 12 Month Treatment in Patients With C3G or IC-MPGN Treated With ACH-0144471
Status: TERMINATED
Conditions: C3 Glomerulonephritis|C3 Glomerulopathy|Immune Complex Membranoproliferative Glomerulonephritis|IC-MPGN|Dense Deposit Disease
Interventions: DRUG: Danicopan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of Recombinant Anti-epidermal Growth Factor Receptor(EGFR) Monoclonal Antibody in Patients With Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: BIOLOGICAL: Recombinant full human Anti-EGFR Monoclonal Antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Nutritional Supplementation on Occupational Performance in Firefighters
Status: COMPLETED
Conditions: Fatigue
Interventions: DIETARY_SUPPLEMENT: Creatine Monohydrate|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Neuroplasticity in Auditory Aging_Project 2 Aims 1 and 2
Status: RECRUITING
Conditions: Auditory Perceptual Disorders|Aging Problems
Interventions: BEHAVIORAL: Auditory training: temporal cues
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of CD19 Specific Chimeric Antigen Receptor Positive T Cells (CAR-T) in ALL and NHL
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia|Non Hodgkin Lymphoma
Interventions: BIOLOGICAL: Car-T Cell Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EFFECTIVENESS OF SINGLE DOSE ORAL DEXAMETHASONE VERSUS MULTIDOSE PREDNISOLONE FOR TREATMENT OF ACUTE EXACERBATIONS OF ASTHMA AMONG CHILDREN ATTENDING THE EMERGENCY DEPARTMENT OF CHILDREN HOSPITAL, ISLAMABAD
Status: ENROLLING_BY_INVITATION
Conditions: Asthma in Children
Interventions: DRUG: Dexamethasone|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Food Intake and IgA Microbiota in Anorexia Nervosa
Status: RECRUITING
Conditions: Anorexia Nervosa|Healthy Volunteer
Interventions: OTHER: Stool sample|OTHER: Food intake evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: EARLYEMOLLIENT - Feasibility of Early Emollient Use in Children With Atopic Eczema
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: OTHER: LIPIKAR BAUME AP+ emollient
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: High Dose Ritonavir/Lopinavir Liquid Formulation in Salvage Therapy for Protease Inhibitor Resistant HIV Disease
Status: UNKNOWN
Conditions: HIV|AIDS
Interventions: DRUG: Kaletra (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Demonstrate Non-inferiority of Combination of 5 mg Amlodipine/ 80 mg Valsartan to 160 mg Valsartan Alone
Status: COMPLETED
Conditions: Hypertension|High Blood Pressure
Interventions: DRUG: Amlodipine 5mg/Valsartan 80 mg|DRUG: Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Smell in COVID-19 and Efficacy of Nasal Theophylline (SCENT 3)
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: DRUG: theophylline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Low-dose S-ketamine in Women With Prenatal Depression
Status: COMPLETED
Conditions: Prenatal Depression|Ketamine|Postpartum Depression
Interventions: DRUG: S-ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: DAAs Treatment for Chronic HCV/HBV Co-infection Patients(DASCO)
Status: COMPLETED
Conditions: Chronic Hepatitis C Infection|HBV Coinfection|Hepatitis B Reactivation
Interventions: DRUG: Ledipasvir/Sofosbuvir|DRUG: Sofosbuvir and Daclatasvir|DRUG: Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir|DRUG: Entecavir|DRUG: Tenofovir disoproxil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atorvastatin for Prevention of Postoperative Atrial Fibrillation After Off-Pump Coronary Artery Bypass Grafting Surgery
Status: COMPLETED
Conditions: Coronary Artery Bypass
Interventions: DRUG: atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Safety and Efficacy of the Probiotic Bifidobacterium Longum ES1 and the Post Biotic Heat-treated Bifidobacterium Longum ES1 (HT-ES1) on IBS Symptom Severity in Patients With Diarrhoea Predominant Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Diarrhea
Interventions: OTHER: ES 1|OTHER: HT ES1|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: RESPONSE-2-PAD to Reduce Sedentary Time in Peripheral Arterial Disease Patients
Status: RECRUITING
Conditions: Peripheral Arterial Disease|Sedentary Behavior|Sedentary Time|Peripheral Arterial Occlusive Disease
Interventions: BEHAVIORAL: RESPONSE-2-PAD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Transcranial Magnetic Stimulation (TMS) in Smoking Cessation, Combining Withdrawal Stimulation Followed by Maintenance Stimulation to Prevent Relapse.
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DEVICE: Active TCS|DEVICE: Placebo TCS|DRUG: nicotine treatment|OTHER: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-Guided Treatments for Shoulder Pain in Wheelchair Users With Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries|Tendinopathy|Rotator Cuff Tears|Shoulder Pain
Interventions: DEVICE: Lipogems|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antioxidant and Immunomodulator Properties of Viusid in Patients With Chronic Hepatitis C
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DIETARY_SUPPLEMENT: Viusid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pedunculo-Pontin Nucleus (PPN) - Deep Brain Stimulation (DBS) in Gait and Balance Disturbance in Parkinson's Disease (PPN-GAB-PARK Study)
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: DEVICE: Deep brain stimulation electrode
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Femoroacetabular Impingement RandomiSed Controlled Trial
Status: COMPLETED
Conditions: Femoroacetabular Impingement
Interventions: PROCEDURE: Arthroscopic Lavage|PROCEDURE: Arthroscopic Osteochondroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise-induced Ischemia and the Influence of Pain Modulation in a Nerve Growth Factor (NGF) Model
Status: UNKNOWN
Conditions: Pain Response|Hyperalgesia|Healthy Subjects
Interventions: DRUG: NGF|DRUG: Isotonic-saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intermittent Fasting and CLL/SLL
Status: COMPLETED
Conditions: Neoplasms|Leukemia, Lymphocytic, Chronic|Lymphoma, Small Lymphocytic|Intermittent Fasting|Diet Habit|Inflammation
Interventions: OTHER: Intermittent fast
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Graft-Versus-Host Disease (aGvHD) Prophylaxis With ATG-Fresenius in Matched Unrelated Donor-Stem Cell Transplantation (MUD-SCT)
Status: COMPLETED
Conditions: Graft vs Host Disease
Interventions: DRUG: ATG-Fresenius S
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Interpretive Biases in Children With Social Anxiety
Status: TERMINATED
Conditions: Social Anxiety|Social Anxiety Disorder
Interventions: BEHAVIORAL: Online Interpretation Training Condition 1|BEHAVIORAL: Online Interpretation Training Condition 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Effects of a Weight Loss Program in Different Formats on Healthy Adults
Status: COMPLETED
Conditions: Overweight and Obesity|Weight Loss
Interventions: BEHAVIORAL: Nutrisystem Turbo 10|BEHAVIORAL: Nutrisystem My Way|BEHAVIORAL: Nutrisystem DASH|BEHAVIORAL: Dieting on Your Own (DIY) - DASH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Vismodegib in Patients With Refractory or Relapsed B-cell Lymphoma or Chronic Lymphocytic Leukemia
Status: TERMINATED
Conditions: Diffuse Large B-cell Lymphoma|Indolent Non-hodgkin Lymphoma|Primary Central Nervous System Lymphoma|Chronic Lymphocytic Leukemia
Interventions: DRUG: Vismodegib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Nicotine Patch Adherence Among Latino HIV-Positive Smokers
Status: COMPLETED
Conditions: Smoking
Interventions: BEHAVIORAL: Cessation counseling with adherence focus|BEHAVIORAL: Cessation counseling without adherence focus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Circadian Character of Food Compulsions and Impulses Control Disorders in Parkinsonian Patients With and Without Resting Leg Syndrome
Status: COMPLETED
Conditions: Parkinson Disease|Restless Leg Syndrome
Interventions: BEHAVIORAL: Diary (for reporting all impulse control disorders especially compulsive eating disorders)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Safety and Efficacy of DERMASEAL for the Treatment of Split-Thickness Skin Graft Donor Site Wounds
Status: NOT_YET_RECRUITING
Conditions: Skin Graft Complications
Interventions: COMBINATION_PRODUCT: DERMASEAL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Utilizing Protein During Weight Loss to Impact Physical Function
Status: COMPLETED
Conditions: Obesity|Weight Loss|Diet Modification|Aging|Weight Change, Body|Dietary Habits
Interventions: BEHAVIORAL: Weight loss intervention months 0-6|BEHAVIORAL: Exercise intervention months 0-6|DIETARY_SUPPLEMENT: Carbohydrate supplement for months 0-6|DIETARY_SUPPLEMENT: Protein supplement for months 0-6|DIETARY_SUPPLEMENT: Protein supplement for follow-up months 7-18
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of a Multidisciplinary Consultation Program on Drug Adherence in First Oral Anticancer Treatment
Status: RECRUITING
Conditions: Multidisciplinary Consultation Program|Adherence to Oral Anticancer Treatment|Drug Related Toxicity|Securing Medication Management
Interventions: DEVICE: multidisciplinary consultation program
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study of Erlotinib for the Treatment of Patients With de Novo Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia, Myelomonocytic, Acute
Interventions: DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Two Formulations of Biphasic Insulin Aspart 50 in Healthy Subjects
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: biphasic insulin aspart 50
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pet Partners for Promotion of Academic Life Skills
Status: UNKNOWN
Conditions: Stress Prevention|Cortisol|Anxiety Disorders and Symptoms|Depression Disorders and Symptoms|Executive Functioning|Motivation and Learning|Momentary Emotion|Study Strategies|Perceived Stress|Animal Behavior|Animal Stress|Dyadic Interaction|Alpha-amylase
Interventions: BEHAVIORAL: Animal Assisted Activities|BEHAVIORAL: Academic Stress Management tools
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: An Innovative Treatment for Fistula-in-ano in Crohn Disease : Local Micro Reinjection of Autologous Fat and SVF
Status: COMPLETED
Conditions: Crohn Disease
Interventions: DRUG: stromal vascular fraction (SVF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DP Vs DFR for Management of Geriatric Distal Femur Fractures.
Status: COMPLETED
Conditions: Distal Femur Fracture|Geriatrics
Interventions: PROCEDURE: double plating|PROCEDURE: Distal femoral replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of ADAPTAVIR's Ability to Eliminate Treatment-Resistant Infectious Virus in Peripheral Blood Mononuclear Cells (PBMCs)
Status: UNKNOWN
Conditions: HIV Infections
Interventions: DRUG: Adaptavir (monomeric DAPTA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetic Characteristics Evaluation of GST-HG131 Tablets
Status: UNKNOWN
Conditions: Hepatitis B
Interventions: DRUG: GST-HG131 tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open Label Trial to Decrease Signs and Symptoms of Orthostatic Hypotension Using Midodrine or Intravenous Fluid Bolus in Patients Following Total Hip Arthroplasty
Status: TERMINATED
Conditions: Orthostatic Hypotension
Interventions: DRUG: Midodrine|OTHER: Intravenous fluid bolus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transdiagnostic Versus Diagnosis-specific Cognitive-behavioral Therapy
Status: RECRUITING
Conditions: Panic Disorder|Generalized Anxiety Disorder|Social Anxiety Disorder|Obsessive-Compulsive Disorder|Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Unified protocol|BEHAVIORAL: Diagnosis-specific cognitive-behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oral BT-11 in Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: BT-11 (440 mg)|DRUG: BT-11 (880 mg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7486967 in Participants With Early Idiopathic Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: RO7486967|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Efficacy Study of CLS003 ICVT in Subjects With Cutaneous Warts.
Status: COMPLETED
Conditions: Cutaneous Warts
Interventions: DRUG: CLS003|DRUG: Furosemide|DRUG: Digoxin|DRUG: Vehicle topical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single-center Pathophysiological Study of the Role of Inflammation, Changes in the Intestinal Epithelial Barrier and the Intestinal Microbiota in Parkinson's Disease
Status: TERMINATED
Conditions: Parkinson's Disease
Interventions: PROCEDURE: Rectosignoidoscopy|PROCEDURE: Coloscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pre-meals of 3-hydroxybutyrate in Type 2 Diabetes
Status: COMPLETED
Conditions: Ketosis|Postprandial Hyperglycemia|Glucose Metabolism Disorders (Including Diabetes Mellitus)
Interventions: DIETARY_SUPPLEMENT: 3-hydroxybutyrate (3-OHB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: INTERVENTION WITH TRANEXAMIC ACID TO REDUCE HAEMORRHAGE DURING LAPAROSCOPIC MYOMECTOMY
Status: UNKNOWN
Conditions: Uterine Fibroid|Myoma;Uterus|Tranexamic Acid Adverse Reaction
Interventions: DRUG: Tranexamic Acid 100 MG/ML|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Ultrasound-guided Peripheral Intravenous Catheter Insertion Technique
Status: TERMINATED
Conditions: Catheterization, Peripheral Venous|Phlebitis|Infiltration
Interventions: OTHER: Ultrasound-guided technique|OTHER: Standard technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety And Efficacy of Sofosbuvir/Velpatasvir/Voxilaprevir Fixed-Dose Combination for 12 Weeks in Adults Who Participated in a Prior Gilead-Sponsored HCV Treatment Study
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: SOF/VEL/VOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Additional Fentanyl to Epidural Bupivacaine for Post-Thoracotomy Pain in Neonates
Status: COMPLETED
Conditions: Congenital Cystic Adenomatoid Malformation
Interventions: DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Efficacy of AMB-05X Injections in Subjects With TGCT
Status: COMPLETED
Conditions: Pigmented Villonodular Synovitis|TGCT|Tenosynovial Giant Cell Tumor
Interventions: BIOLOGICAL: AMB-05X
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Arm Study of Neurocognitive Outcomes in Patients With Brain Metastases Managed With Stereotactic Radiosurgery (SRS)
Status: TERMINATED
Conditions: Brain Metastases
Interventions: OTHER: Stereotactic radiosurgery (SRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Proof-Of-Concept Study Of Intravitreal AL-78898A In Patients With Geographic Atrophy (GA) Associated With Age-Related Macular Degeneration (AMD)
Status: TERMINATED
Conditions: Geographic Atrophy
Interventions: DRUG: Al-78898A|DRUG: Sham injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Zinc in the Treatment of Bronchiolitis and Prevention of Wheezing Respiratory Illness in Children Less Than Two Years Old
Status: COMPLETED
Conditions: Bronchiolitis
Interventions: DRUG: Zinc sulphate 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Ablation of Genicular Nerves for Advanced Osteoarthrosis of the Knee Joint 1 Year Follow-up.
Status: COMPLETED
Conditions: Painful Osteoarthritis of the Knee
Interventions: PROCEDURE: RF treatment|RADIATION: radiofrequency ablation|DEVICE: ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial on Different Dosages of Vitamin D in Preterm Infants With Late-onset Sepsis
Status: COMPLETED
Conditions: Prematurity|Late-onset Sepsis
Interventions: DRUG: High-dose vitamin D 3|DRUG: Conventional-Dose Vitamin D 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Diacerein in the Metabolic Control of Patients With DM Type 2 and Secondary Failure to Metformin
Status: UNKNOWN
Conditions: Diabetes-Related Complications|Diabetes Mellitus, Type 2|Insulin Resistance
Interventions: DRUG: Diacerein|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ischemic And Bleeding Risk Assessment After TAVR
Status: RECRUITING
Conditions: Aortic Valve Stenosis|Transcatheter Aortic Valve Replacement
Interventions: OTHER: Low vs Intermediate vs High surgical risk stratified according with SAPT/DAPT/OAC and OAC+SAPT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Immunonutritional Approach to the Prevention of Skin Cancer
Status: COMPLETED
Conditions: Skin Cancer
Interventions: DIETARY_SUPPLEMENT: Omega-3 PUFA|DIETARY_SUPPLEMENT: Gelatine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION