pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Use of Self Inflating Tissue Expanders In The Treatment Of Alveolar Cleft
Status: UNKNOWN
Conditions: Cleft of Alveolar Ridge
Interventions: DEVICE: Osmed self inflating tissue expanders|OTHER: Iliac bone graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Recombinant Human Clara Cell 10 Protein (rhCC10) Administered to Premature Neonates With Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Respiratory Distress Syndrome in Premature Infant|Bronchopulmonary Dysplasia
Interventions: DRUG: Half normal saline|DRUG: Low Dose rhCC10|DRUG: High dose rhCC10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Cryotherapy and LLLT on Postoperative Pain After Root Canal Treatment
Status: COMPLETED
Conditions: Root Canal Infection|Pain, Postoperative|Cryotherapy Effect|Laser|Pulpitis
Interventions: PROCEDURE: Control|PROCEDURE: Laser|PROCEDURE: Cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects on Tablets Containing Probiotic Candidate Strains
Status: COMPLETED
Conditions: Gingivitis
Interventions: DIETARY_SUPPLEMENT: Probiotic tablets|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Incretin Hormone Antagonism After Bariatric Surgery
Status: COMPLETED
Conditions: Bariatric Surgery
Interventions: OTHER: Placebo|OTHER: GLP-1 antagonism|OTHER: GIP antagonism|OTHER: GLP-1 and GIP antagonism
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment Regimens in Meibomian Gland Dysfunction
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: Lifitegrast Ophthalmic|DRUG: Systane Free|DEVICE: Lipiflow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: VERARE_2 Efficacy of the Observation of Virtual Motor Actions for the Improvement of Gait in Patients With ICU-weakness
Status: RECRUITING
Conditions: ICU-weakness
Interventions: OTHER: Virtual Reality Observations|OTHER: Relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Development of a Planned Behavior Theory-Based Physical Activity Application for High School Adolescent Girls
Status: NOT_YET_RECRUITING
Conditions: Sedentary Lifestyle|Sedentary Behavior|Physical Activity Level
Interventions: BEHAVIORAL: Physical Activity Intervention Based on Theory of Planned Behavior|BEHAVIORAL: Physical Activity Intervention Based on Theory of Planned Behavior with Parental Participation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Shaping Anesthetic Techniques to Reduce Post-operative Delirium
Status: COMPLETED
Conditions: Delirium|Lumbar Radiculopathy|Lumbar Osteoarthritis|Lumbar Spine Disc Degeneration
Interventions: PROCEDURE: Light sedation with propofol|PROCEDURE: Induction with propofol|PROCEDURE: Maintenance anesthetic using a volatile anesthetic|PROCEDURE: Muscle relaxant during maintenance anesthesia|PROCEDURE: Pain control with fentanyl|PROCEDURE: Bispectral Index (BIS) monitoring for depth of anesthesia|PROCEDURE: Spinal Anesthesia|PROCEDURE: Midazolam administered during spinal anesthesia|PROCEDURE: Cerebrospinal fluid collection|PROCEDURE: Administration of intrathecal morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Frequency Intensive Autologous PRP Injection and Genicular Nerve Blocks in Treating Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Autologous platelet rich plasma and 5% dextrose solution injections.
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Perilesional Biopsy in Diagnosis of Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: PROCEDURE: Perilesional/regional systematic biopsy|PROCEDURE: Combination of systematic biopsy and targeted biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Everolimus Rescue Immunosuppression in the Treatment of Chronic Allograft Dysfunction in Renal Transplant Recipients
Status: COMPLETED
Conditions: Chronic Allograft Dysfunction in Renal Transplantation
Interventions: DRUG: everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Integrated Cardiopulmonary Ultrasound on Clinical Outcome of Shocked Patients in Intensive Care Unit
Status: COMPLETED
Conditions: Shock
Interventions: PROCEDURE: care cardio-pulmonary ultrasound|OTHER: treatment without any use of point of care cardio-pulmonary ultrasound scans for guidance of the management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Optimizing Audit and Feedback for Primary Care
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Coronary Artery Disease
Interventions: OTHER: Worksheet to facilitate goal-setting and action plans
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effectiveness of Lng IUD for Treatment of the Patient Undergone Conservative Surgery for Pelvic Endometriosis
Status: COMPLETED
Conditions: Endometriosis|Pelvic Pain|Dysmenorrhea
Interventions: DEVICE: Levonorgestrel IUD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Idasanutlin Monotherapy in Participants With Hydroxyurea-Resistant/Intolerant Polycythemia Vera
Status: TERMINATED
Conditions: Polycythemia Vera
Interventions: DRUG: Idasanutlin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneously Administered Mosunetuzumab to Participants With Systemic Lupus Erythematosus
Status: ACTIVE_NOT_RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Mosunetuzumab|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Reno-Cardiac Action of Dapagliflozin In Advanced Heart Failure Patients on Heart Transplant Waiting List
Status: WITHDRAWN
Conditions: End-stage Heart Failure
Interventions: DRUG: Dapagliflozin 10mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effects of Prebiotics on Sleep, the Gut Microbiome, Cognition, Immune Function and Stress
Status: UNKNOWN
Conditions: Sleep
Interventions: DIETARY_SUPPLEMENT: Prebiotic|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Trial Evaluating Modified FOLFIRINOX and Modified FOLFOX in the Treatment of Locally Advanced or Metastatic Small Bowel Adenocarcinoma
Status: RECRUITING
Conditions: Locally Advanced or Metastatic Small Bowel Adenocarcinoma
Interventions: DRUG: modified FOLFORINOX|DRUG: Modified FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Olaparib in Combination With Vorinostat in Patients With Relapsed/Refractory and/or Metastatic Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer Metastatic|Breast Cancer
Interventions: DRUG: Olaparib|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compensation Mechanisms in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: GENETIC: Identification of COMT HH, COMT HL or COMT LL genes|OTHER: Brain MRI with resting state scan|OTHER: Brain MPET
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase II Study of Albumin Bound Paclitaxel With 5-FU and CF as Second Line in Taxanes Naive Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Caner
Interventions: DRUG: Albumin Bound Paclitaxel|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas
Status: TERMINATED
Conditions: Adult Anaplastic Ependymoma|Adult Anaplastic Oligodendroglioma|Adult Brain Stem Glioma|Adult Diffuse Astrocytoma|Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Adult Mixed Glioma|Adult Oligodendroglioma|Adult Pilocytic Astrocytoma|Adult Pineal Gland Astrocytoma|Adult Subependymal Giant Cell Astrocytoma|Childhood High-grade Cerebellar Astrocytoma|Childhood High-grade Cerebral Astrocytoma|Childhood Low-grade Cerebellar Astrocytoma|Childhood Low-grade Cerebral Astrocytoma|Recurrent Adult Brain Tumor|Recurrent Childhood Anaplastic Astrocytoma|Recurrent Childhood Anaplastic Oligoastrocytoma|Recurrent Childhood Anaplastic Oligodendroglioma|Recurrent Childhood Brain Stem Glioma|Recurrent Childhood Cerebellar Astrocytoma|Recurrent Childhood Cerebral Astrocytoma|Recurrent Childhood Diffuse Astrocytoma|Recurrent Childhood Fibrillary Astrocytoma|Recurrent Childhood Gemistocytic Astrocytoma|Recurrent Childhood Giant Cell Glioblastoma|Recurrent Childhood Glioblastoma|Recurrent Childhood Gliomatosis Cerebri|Recurrent Childhood Gliosarcoma|Recurrent Childhood Oligoastrocytoma|Recurrent Childhood Oligodendroglioma|Recurrent Childhood Pilomyxoid Astrocytoma|Recurrent Childhood Protoplasmic Astrocytoma|Recurrent Childhood Subependymal Giant Cell Astrocytoma|Recurrent Childhood Visual Pathway and Hypothalamic Glioma|Recurrent Childhood Visual Pathway Glioma|Untreated Childhood Anaplastic Astrocytoma|Untreated Childhood Anaplastic Oligoastrocytoma|Untreated Childhood Anaplastic Oligodendroglioma|Untreated Childhood Brain Stem Glioma|Untreated Childhood Cerebellar Astrocytoma|Untreated Childhood Cerebral Astrocytoma|Untreated Childhood Diffuse Astrocytoma|Untreated Childhood Fibrillary Astrocytoma|Untreated Childhood Gemistocytic Astrocytoma|Untreated Childhood Giant Cell Glioblastoma|Untreated Childhood Glioblastoma|Untreated Childhood Gliomatosis Cerebri|Untreated Childhood Gliosarcoma|Untreated Childhood Oligoastrocytoma|Untreated Childhood Oligodendroglioma|Untreated Childhood Pilomyxoid Astrocytoma|Untreated Childhood Protoplasmic Astrocytoma|Untreated Childhood Subependymal Giant Cell Astrocytoma|Untreated Childhood Visual Pathway and Hypothalamic Glioma|Untreated Childhood Visual Pathway Glioma
Interventions: DRUG: 18F-fluoro-dihydroxyphenylalanine|PROCEDURE: Positron emission tomography (PET)|PROCEDURE: Computed tomography (CT)|PROCEDURE: Magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination of Duloxetine and Pregabalin to Improve Postoperative Pain
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Duloxetine and Pregabalin|DRUG: pregabalin|DRUG: sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Immunogenicity Study of 2 Investigational Preventive HIV Vaccines
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: Adjuvanted GSK investigational HIV vaccine formulation 1|BIOLOGICAL: Adjuvanted GSK investigational HIV vaccine formulation 2|BIOLOGICAL: Ad35 investigational HIV vaccine|BIOLOGICAL: Adjuvanted GSK investigational HIV vaccine formulation 2|BIOLOGICAL: Adjuvanted GSK investigational HIV vaccine formulation 2|BIOLOGICAL: Ad35 investigational HIV vaccine|BIOLOGICAL: Ad35 investigational HIV vaccine|BIOLOGICAL: Placebo (saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Safety and Efficacy of Nasea(R)/Ramosetron Inj. in Patients Undergoing Facial Bone Fracture Operations
Status: TERMINATED
Conditions: Facial Bones Fracture
Interventions: DRUG: Ramosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Comparing the Outcome of Electrical Stimulation and Physical Therapy in Patellofemoral Pain Syndrome
Status: RECRUITING
Conditions: Patellofemoral Pain Syndrome
Interventions: DEVICE: EMS|OTHER: Physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Volume Versus Concentration: Clinical Effectiveness of Single Shot Quadrates Lumborum Block Using Either a High Volume/Low Concentration or Low Volume/High Concentration Injectate for Total Hip Arthroplasty.
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: Drug: Bupivacaine 0.375% 20 mL|DRUG: Drug: Bupivacaine 0.375% diluted to 0.1875%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Of Chemokine Coreceptor 5 (CCR5) Antagonist GW873140 In R5-Tropic Treatment-Experienced HIV-Infected Subjects
Status: TERMINATED
Conditions: Infection, Human Immunodeficiency Virus I
Interventions: DRUG: GW873140
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Real Word Evidence With 1L Polyethylene Glycol (PEG)+ Ascorbic Acid in Iberia
Status: COMPLETED
Conditions: Colon Cancer|Colon Disease|Colon Cleansing
Interventions: DRUG: 1L PEG + ASCORBIC ACID
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 6-Month Phase I/II Open Label PRTX-100 in Previous Rheumatoid Arthritis Study Participants and Sera Collection
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: PRTX-100
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Belatacept Compared to Tacrolimus in Deceased Donor Renal Transplant Recipients
Status: COMPLETED
Conditions: Implant or Graft; Rejection
Interventions: DRUG: Belatacept|DRUG: Tacrolimus|DRUG: Mycophenolate|DRUG: rATG|DRUG: Methylprednisolone|PROCEDURE: Renal transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alemtuzumab and Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Undifferentiated Leukemia|B-cell Adult Acute Lymphoblastic Leukemia|B-cell Childhood Acute Lymphoblastic Leukemia|L1 Adult Acute Lymphoblastic Leukemia|L1 Childhood Acute Lymphoblastic Leukemia|L2 Adult Acute Lymphoblastic Leukemia|L2 Childhood Acute Lymphoblastic Leukemia|Philadelphia Chromosome Negative Adult Precursor Acute Lymphoblastic Leukemia|Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia|Philadelphia Chromosome Positive Childhood Precursor Acute Lymphoblastic Leukemia|T-cell Adult Acute Lymphoblastic Leukemia|T-cell Childhood Acute Lymphoblastic Leukemia|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia
Interventions: DRUG: allopurinol|DRUG: cyclophosphamide|DRUG: daunorubicin hydrochloride|DRUG: vincristine sulfate|DRUG: dexamethasone|DRUG: asparaginase|BIOLOGICAL: filgrastim|DRUG: imatinib mesylate|DRUG: methotrexate|DRUG: cytarabine|DRUG: trimethoprim-sulfamethoxazole|DRUG: mercaptopurine|DRUG: leucovorin calcium|BIOLOGICAL: alemtuzumab|DRUG: acyclovir|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Aldesleukin (IL-2) Following the Administration of Zanolimumab (Anti-CD4mAb) in Metastatic Melanoma and Metastatic Renal Cancer
Status: TERMINATED
Conditions: Metastatic Melanoma|Metastatic Renal Cancer
Interventions: DRUG: Zanolimumab|DRUG: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-intensity Interval Training Prescriptions to Reduce the Risk of Complications Linked to Type 2 Diabetes: the Role of Interval Length on Clinical Benefits and on Physiological Mechanisms
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: High-intensity interval training (HIIT)-4|OTHER: High-intensity interval training (HIIT)-10|OTHER: Rest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Iron Fortified Complementary Food and IPT of Malaria in Young Children in Côte d'Ivoire
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: SP/amodiaquine|DIETARY_SUPPLEMENT: FeFum fortified porridge|DRUG: SP/Amodiaquine + FeFum fortified porridge|DIETARY_SUPPLEMENT: Ferric pyrophosphate fortified porridge|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Slowly Digestible Carbohydrates and the Ileal Brake
Status: COMPLETED
Conditions: Obesity|Diabetes Mellitus, Type 2|Appetitive Behavior
Interventions: OTHER: Isomaltooligosaccharides (IMOs)|OTHER: Xtend® sucromalt|OTHER: Combination of IMOs and Xtend® sucromalt|OTHER: Raw corn starch|OTHER: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Applicability of the CDEIS to Data Obtained by the Colonic Capsule Endoscopy in Crohn Disease
Status: COMPLETED
Conditions: Crohn Disease
Interventions: PROCEDURE: Colon Capsule Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: HI-Light Pilot Trial for Vitiligo: Hand Held NB-UVB for Early or Focal Vitiligo at Home
Status: COMPLETED
Conditions: Vitiligo
Interventions: DEVICE: 311 nm NB-UVB light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Differences in Atorvastatin Metabolite Ratios as a Diagnostic Tool in Detecting Atorvastatin Induced Myotoxicity
Status: COMPLETED
Conditions: Muscular Diseases
Interventions: DRUG: atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Pregabalin vs Placebo for Generalized Anxiety Disorder (GAD) Symptoms in Subjects Discontinuing Benzodiazepine Treatment and Remaining 6 Weeks on Study Medication, Free From Benzodiazepine Use.
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: DRUG: Pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Terpene-enriched Cannabidiol (CBD) Oil in ADHD
Status: RECRUITING
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: DRUG: Oral CBD oil enriched with terpenes|DRUG: Oral Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AI Assisted Reader Evaluation in Acute Computed Tomography (CT) Head Interpretation
Status: ACTIVE_NOT_RECRUITING
Conditions: Intracranial Hemorrhages|Acute Ischemic Stroke|Hydrocephalus|Cerebral Infarction|Cerebral Edema|Cerebral Injury
Interventions: OTHER: Ground truthing|OTHER: Reading
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Venetoclax Combined With BEAM Pretreatment in Autologous Transplantation for DLBCL
Status: NOT_YET_RECRUITING
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: Venetoclax|DRUG: Carmustine|DRUG: Cytarabine|DRUG: Etoposide|DRUG: Melphalan|PROCEDURE: Hematopoietic Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Starvation in the Treatment of Diabetic Ketoacidosis
Status: ENROLLING_BY_INVITATION
Conditions: Diabetes Mellitus|Diabetic Ketoacidosis
Interventions: OTHER: Early feeding with an oral diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Platelet Rich Fibrin Augmented Tympanoplasty Versus Cartilage Tympanoplasty
Status: COMPLETED
Conditions: Chronic Suppurative Otitis Media
Interventions: PROCEDURE: cartilage tympanoplasty|PROCEDURE: platelet rich fibrin augmented tympanoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Injection Molded Polyetheretherketone (PEEK) Framework and Cobalt Chromium Framework Removable Partial Dentures Regarding Periodontal Health of Abutment Teeth
Status: UNKNOWN
Conditions: Mandibular Prosthesis User
Interventions: DEVICE: cobalt-chromium framework partial dentures|DEVICE: PEEK framework partial dentures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment In a Real World Setting of the Effect of Inhaled Steroid-based Triple Therapy Versus the Combination of Tiotropium and Olodaterol on Reducing Chronic Obstructive Pulmonary Disease (COPD) Exacerbations [AIRWISE]
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Stiolto Respimat|DRUG: ICS (Inhaled Corticosteroid) (Triple therapy)|DRUG: LABA (Long-Acting Beta Agonist) (Triple therapy)|DRUG: LAMA (Long-Acting Muscarinic Antagonist) (Triple therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vibration Therapy on Bone in Persons With Sub-acute Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Vibration: Right Leg and No Vibration: Left Leg.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Preoperative Carbohydrate Loading for Enhancing Recovery After Radical Cystectomy
Status: RECRUITING
Conditions: Anesthesia|Urologic Cancer|Surgery
Interventions: DIETARY_SUPPLEMENT: Maltodextrin 12.5%|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irinotecan With or Without Capecitabine as Second-Line Therapy in Treating Older Patients With Progressive, Metastatic Colorectal Cancer That Cannot Be Removed By Surgery
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: capecitabine|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PECS II Block in Thoracic Outlet Decompression
Status: COMPLETED
Conditions: Thoracic Outlet Syndrome
Interventions: PROCEDURE: Pectoral nerve block type II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Unified platforM for a Better integRal Evaluation of MyeLodyspLastic Syndromes in SpAin-Strategy for Unraveling Personalized genoMic Medicine in Public heAlth System (UMBRELLA-SUMMA)
Status: RECRUITING
Conditions: Myelodysplastic Syndromes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Biodistribution, Dosimetry and Performance of [68Ga]Ga-DOTA-Siglec-9 in Healthy and Patients With Rheumatoid Arthritis, Vasculitis or Pulmonary Sarcoidosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Subjects|Rheumatoid Arthritis|Vasculitis|Pulmonary Sarcoidosis
Interventions: OTHER: [68Ga]Ga-DOTA-Siglec-9
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Pimicotinib (ABSK021) for Tenosynovial Giant Cell Tumor (MANEUVER)
Status: ACTIVE_NOT_RECRUITING
Conditions: Tenosynovial Giant Cell Tumor|Pigmented Villonodular Synovitis|Giant Cell Tumor of Tendon Sheath
Interventions: DRUG: Pimicotinib(ABSK021)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thoracic Lymphatic Pump Techniques for Reducing Lung Volumes in Persons With Chronic Obstructive Pulmonary Disease
Status: WITHDRAWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: PROCEDURE: Compressive Thoracic Lymphatic Pump|PROCEDURE: Classic Thoracic Lymphatic Pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evuzamitide in PET/CT to Measure Potential Therapeutic Response in ATTR
Status: COMPLETED
Conditions: Transthyretin Amyloidosis
Interventions: DRUG: I 124-Evuzamitide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Safety, Tolerability and Pharmacokinetic Study of Two Formulations of Metronidazole Versus Immediate Release Metronidazole in Patient With C. Difficile Colitis
Status: COMPLETED
Conditions: Clostridium Difficile Associated Diarrhea
Interventions: DRUG: Metronidazole|DRUG: Metronidazole-DRF1|DRUG: Metronidazole-DRF2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Boosted Atazanavir and Truvada Given Once-Daily - BATON Study
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Truvada|DRUG: Atazanavir|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Therapy for Carpal Tunnel Syndrome (CTS)
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: DEVICE: EMS Therasonic 460 Primo Ultrasound therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of 18F-AlF-NOTA-Neurotensin PET/CT for Imaging Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DRUG: 18F-AlF-NOTA-neurotensin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Study of the Use of Beta Blocker and Oral Corticosteroid in the Treatment of Infantile Hemangioma
Status: COMPLETED
Conditions: Hemangioma
Interventions: DRUG: Propranolol|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Range Study to Evaluate the Efficacy and Safety of AV5080 in Patients With Influenza
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: AV5080|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PROState Cancer Patients Initiating Hormone Therapy: Effect of Exercise on CARDIOvascular Health (PROSCARDIO)
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: OTHER: Standard care plus exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: House Dust Mite Injection Immunotherapy in Elderly Patients.
Status: COMPLETED
Conditions: Allergen Immunotherapy in Elderly Patients
Interventions: BIOLOGICAL: Purethal Mites|OTHER: placebo injection|DIAGNOSTIC_TEST: monitoring of allergen specific IgE|DIAGNOSTIC_TEST: monitoring of allergen specific IgG4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial Investigating Optimal Treatment for Chronic Subdural Hematoma
Status: COMPLETED
Conditions: Chronic Subdural Hematoma
Interventions: PROCEDURE: Mini-craniotomy|PROCEDURE: Twist Drill Craniostomy|PROCEDURE: Burr Hole Craniostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Empagliflozin on Diuresis and Renal Function in Patients With Acute Decompensated Heart Failure
Status: COMPLETED
Conditions: Acute Decompensated Heart Failure
Interventions: DRUG: Empagliflozin 25 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TMS Stimulation and Cognitive Training in Alzheimer Patients
Status: COMPLETED
Conditions: Alzheimer Disease|Mild to Moderate
Interventions: DEVICE: Sham-NICE-System|DEVICE: NICE-System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Oral Fludarabine Phosphate in Combination With Mitoxantrone as First Line Treatment in Follicular NHL
Status: COMPLETED
Conditions: Non Hodgkin Lymphoma
Interventions: DRUG: Fludarabine Phosphate (Fludara)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Elobixibat in Adults With NAFLD or NASH
Status: COMPLETED
Conditions: NAFLD|NASH
Interventions: DRUG: Elobixibat|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endostatin Combined With Chemotherapy for Adjuvant Treatment of Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: DRUG: Docetaxel|DRUG: Nedaplatin|DRUG: Endostar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Open-label, Randomized Controlled, Multicenter Clinical Study of Haplo-HSCT Using a TBI or TMLI Conditioning Regimen for Adult ALL
Status: NOT_YET_RECRUITING
Conditions: Acute Lymphoblastic Leukemia, Adult
Interventions: RADIATION: TBI|RADIATION: TMLI|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare Hemodynamic Parameters of Propofol and Sevoflurane During CPB Time in Undergoing CABG to Avoid Lactate Level
Status: UNKNOWN
Conditions: Hemodynamic Instability
Interventions: DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PPG vs. ICG in Gastrointestinal Resections
Status: RECRUITING
Conditions: Anastomosis|Perfusion
Interventions: DEVICE: ICG fluorescence imaging technology|DEVICE: Imaging photoplethysmography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Immunogenicity Study of Live Attenuated Vaccine Against Herpes Zoster in Chinese Adults Aged 50 Years and Older
Status: COMPLETED
Conditions: Herpes Zoster
Interventions: BIOLOGICAL: the vaccine with high doses of virus content between 4.7～5.0 lgPFU|BIOLOGICAL: the vaccine with low doses of virus content between 4.7～5.0 lgPFU|BIOLOGICAL: the vaccine with high doses of virus content between 4.3～5.0 lgPFU|BIOLOGICAL: the vaccine with middle doses of virus content between 4.3～5.0 lgPFU|BIOLOGICAL: the vaccine with low doses of virus content between 4.3～5.0 lgPFU|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Dapagliflozin As Additional Treatment To Liraglutide And Insulin In Patients With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Dapagliflozin|DRUG: Insulin|DRUG: Liraglutide|DRUG: Dapagliflozin placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Impact of Smoking Status on Allergen-induced Nasal Airway Inflammation Using a Cat Hair (Felis Domesticus) Extract Nasal Allergen Challenge Model
Status: WITHDRAWN
Conditions: Tobacco Smoking|Healthy Participants|E-cigarette Smokers
Interventions: BIOLOGICAL: Felis Domesticus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Acetylic Salicylic Acid for the Treatment of Chronic Obstructive Pulmonary Disease
Status: UNKNOWN
Conditions: COPD
Interventions: DRUG: Acetylsalicylic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endogenous Opioid Modulation by Ketamine
Status: WITHDRAWN
Conditions: Major Depressive Disorder
Interventions: DRUG: Ketamine Hydrochloride|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Small Variations in Shoe Heel Height on Gait in People With a Transtibial Amputation
Status: COMPLETED
Conditions: Lower Limb Amputation Below Knee (Injury)
Interventions: OTHER: Cork inlay wedge
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: C-11 Choline PET-CT Scan in Finding Metastases in Patients With Newly Diagnosed High-Risk Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: needle biopsy|DRUG: PET-CT scans supplemented with 11C-Choline tracer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Oral Lucitanib (E-3810), a Dual VEGFR-FGFR Tyrosine Kinase Inhibitor, in Patients With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Lucitanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Use of Complex Pulse Shapes for DBS in Movement Disorders
Status: COMPLETED
Conditions: Parkinson Disease|Essential Tremor
Interventions: DEVICE: Boston Scientific: Study tool computer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Early Intervention Based on Neonatal Crawling in Very Premature Infants at Risk For Neurodevelopmental Disorder
Status: RECRUITING
Conditions: Prematurity|Extreme Prematurity|Infant Development|Brain Damage|Motor and Developmental Delay
Interventions: BEHAVIORAL: Crawling stimulation with a mini-skateboard (i.e. the crawliskate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is the IVF Outcome Dependent on the Time Interval Between hCG Administration and Oocyte Retrieval?
Status: COMPLETED
Conditions: Subfertility
Interventions: PROCEDURE: Oocyte retrieval will be performed 36 h or 38 h after hCG administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MICBT for Non-underweight Adults With Eating Disorders
Status: RECRUITING
Conditions: Eating Disorders|Maladaptive Personality Trait|Emotion Regulation|Personality|Personality Disorders|Social Interaction|Perfectionism|Self Esteem|Cognitive Dysfunction|Dysfunctional Behavior, Psychology
Interventions: OTHER: CBT-F+MIT|OTHER: CBT-E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Fish Oil Supplementation on Vocal Performance
Status: COMPLETED
Conditions: Voice Range Profile|Reflux Symptom Index|Evaluation of Ability to Sing Easily|Body Composition
Interventions: DIETARY_SUPPLEMENT: omega-3 PUFA supplement|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Peri-Incisional Drug Injection in Lumbar Spine Surgery
Status: WITHDRAWN
Conditions: Lumbar Disc Herniation|Degenerative Disc Disease|Spondylolisthesis
Interventions: DRUG: Morphine|DRUG: Epinephrine|DRUG: naropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate Effects of an Oral Rinse on Plaque and Gingivitis
Status: COMPLETED
Conditions: Plaque
Interventions: DEVICE: 3M™ Oral Rinse|OTHER: Vehicle Control Oral Rinse|DEVICE: PerioShield™ Oral Health Rinse|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Evaluation of AutoFlow Mode During Mechanical Ventilation
Status: COMPLETED
Conditions: Ventilation, Mechanical
Interventions: DEVICE: AutoFlow mode on Evita 4 Dräger ventilators|DEVICE: Evita 4 Dräger ventilators
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Accelerated Partial Breast Radiotherapy With Either Mammosite or Intensity Modulated Radiotherapy
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: RADIATION: Breast Brachytherapy with Mammosite RTS|RADIATION: Intensity Modulated Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab (Anti-PD-1) and AMG386 (Angiopoietin-2 (Ang-2) in Patients With Advanced Solid Tumor
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: Pembrolizumab|DRUG: Trebananib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Plasma Neutrophil Gelatinase-Associated Lipocalin (pNGAL) Level in De-resuscitation With Furosemide Group and Control Group
Status: RECRUITING
Conditions: Acute Kidney Injury Due to Sepsis
Interventions: PROCEDURE: Furosemide Injection|PROCEDURE: Placebo Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Using Digital Health Technologies to Prevent Rapid Infant Weight Gain.
Status: WITHDRAWN
Conditions: Breastfeeding|Bottle Feeding|Child Obesity
Interventions: BEHAVIORAL: Intervention|BEHAVIORAL: Text4Baby
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safinamide as Add-On Therapy in Patients With Early Idiopathic Parkinson's Disease Treated With a Stable Dose of a Single Dopamine Agonist
Status: COMPLETED
Conditions: Idiopathic Parkinson's Disease
Interventions: DRUG: Safinamide|DRUG: Safinamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Safety of the Anti-cancer Drugs Tazemetostat and Belinostat in Patients With Lymphomas That Have Resisted Treatment
Status: RECRUITING
Conditions: Recurrent B-Cell Non-Hodgkin Lymphoma|Recurrent Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type|Recurrent Non-Hodgkin Lymphoma|Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma|Recurrent T-Cell Non-Hodgkin Lymphoma|Recurrent Transformed Non-Hodgkin Lymphoma|Refractory B-Cell Non-Hodgkin Lymphoma|Refractory Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type|Refractory Non-Hodgkin Lymphoma|Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma|Refractory T-Cell Non-Hodgkin Lymphoma|Refractory Transformed Non-Hodgkin Lymphoma
Interventions: DRUG: Belinostat|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|OTHER: Pharmacokinetic Study|PROCEDURE: Positron Emission Tomography and Computed Tomography Scan|DRUG: Tazemetostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of HIFU on Sleep Quality Measures in Obese Doubled Chin Women
Status: RECRUITING
Conditions: OBESITY
Interventions: DEVICE: high intensity focused ultrasound|OTHER: Doubled chin exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Evaluation of Urine DNA Methylation/Somatic Mutation Profiling for the Detection of Urothelial Carcinoma
Status: COMPLETED
Conditions: Urothelial Carcinoma|Bladder Cancer
Interventions: OTHER: Active Comparator: Pathology|OTHER: Active Comparator: Clinical Diagnosis|OTHER: Active Comparator: Clinical diagnosis|OTHER: Genetic test: AnchorDx's urine DNA methylation/somatic mutation profiling assay
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safe@Home: A Self-Management Program for Individuals With TBI and Their Families
Status: UNKNOWN
Conditions: Brain Injuries, Traumatic
Interventions: BEHAVIORAL: Safe@Home Intervention Group|OTHER: Usual Care Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MK0524A Bioequivalence Study (0524A-059)
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: niacin (+) laropiprant (Source 1)|DRUG: Comparator: niacin (+) laropiprant (Source 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bendamustine Hydrochloride, Lenalidomide, and Dexamethasone in Treating Patients With Relapsed Multiple Myeloma
Status: COMPLETED
Conditions: Refractory Multiple Myeloma
Interventions: DRUG: bendamustine hydrochloride|DRUG: lenalidomide|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intraperitoneal Ropivacaine on Visceral Pain After Laparoscopic Gastrectomy
Status: NOT_YET_RECRUITING
Conditions: Laparoscopic Gastrectomy|Ropivacaine
Interventions: DRUG: 0.5% Ropivacaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Mood Disorders
Status: COMPLETED
Conditions: Bipolar Disorder|Mood Disorder|Unipolar Depression
Interventions: DEVICE: Magstim Super Rapid Magnetic Stimulator|DEVICE: Cadwell MES-10
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety and Acceptability of Tenofovir 1% Gel in Adolescent Females
Status: WITHDRAWN
Conditions: HIV Prevention
Interventions: DRUG: TFV 1% vaginal gel|DRUG: HEC Placebo Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Apixaban vs Dual Antiplatet Therapy Study After Left Atrial Appendage Occlosure (ADALA)
Status: COMPLETED
Conditions: Left Atrial Appendage Occlusion
Interventions: DRUG: Apixaban vs. DAPT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC