pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Clinical Efficacy of Two Topical Dry Eye Drops for Central Corneal Stain Clearing Over 90 Days
Status: RECRUITING
Conditions: Dry Eye
Interventions: DRUG: nanomicellular cyclosporine 0.09%|DRUG: Lifitegrast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Acthar Gel in Participants With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Acthar Gel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Tislelizumab Plus Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer (NeoSPOT)
Status: RECRUITING
Conditions: Oral Squamous Cell Carcinoma|Oropharyngeal Squamous Cell Carcinoma
Interventions: DRUG: Tislelizumab|DRUG: Albumin-Bound Paclitaxel|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-National Study To Assess How Effective And Safe The Smoking Cessation Medicine Varenicline Is In Smokers Who Have Already Tried Varenicline In The Past As A Prescription Medicine From Their Usual Healthcare Provider
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Varenicline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Controlled Human Malarial Infection by Intravenous Injection of Plasmodium Falciparum Sporozoites in Non-Immune Adults
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: PfSPZ Challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Lumbar Immobilisation by Rigid Brace for Chronic Low Back Pain Patients With Modic 1 Changes (DICO)
Status: TERMINATED
Conditions: Chronic Pain
Interventions: DEVICE: Wearing the rigid brace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HypErthermia as an Additional Treatment for the Biology and Experience of Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy (CBT)|DEVICE: Whole-Body Hyperthermia (WBH)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Galantamine 4 mg Tablet and Reminyl Following a 4 mg Dose in Healthy Subjects Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Galantamine 4 mg Tablet, single dose|DRUG: Reminyl 4 mg Tablet, single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: The Effects of Probiotic Supplementation on Extremely Low Birthweight Infants
Status: TERMINATED
Conditions: Feeding Tolerance
Interventions: DIETARY_SUPPLEMENT: Probiotic Supplemented Group|DIETARY_SUPPLEMENT: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Spinal Cord Stimulation
Status: RECRUITING
Conditions: Chronic Pain
Interventions: DEVICE: Spinal cord stimulation turned on (suggestions: off)|DEVICE: Spinal cord stimulation turned off (suggestions: on)|DEVICE: Spinal cord stimulation turned on with suggestions (suggestions on)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metformin in the Diastolic Dysfunction of Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome X|Diastolic Dysfunction|Insulin Resistance
Interventions: BEHAVIORAL: Lifestyle Counseling|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic-guided TAP Block vs Epidural Analgesia
Status: RECRUITING
Conditions: Post Operative Pain
Interventions: OTHER: Safety and efficiency of post operative analgesia between laparoscopic-assisted TAP block and epidural analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesia for Pediatric Circumcision : Comparison of the Effectiveness of Pudendal Nerve Block to Penile Nerve Block
Status: UNKNOWN
Conditions: Anesthesia|Pediatric Circumcision
Interventions: PROCEDURE: Pudendal nerve block|PROCEDURE: Penile nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Wearable and a Self-management Application for Chronic Obstructive Pulmonary Disease (COPD) Patients at Home
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DEVICE: smartphone, smartwatch, WearCOPDv2 application
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Combined General-epidural vs General Anaesthesia on Postoperative Gastrointestinal Surgery
Status: UNKNOWN
Conditions: Epidural Anesthesia|Infection|Infant, Newborn, Diseases
Interventions: PROCEDURE: Combined general and epidural|PROCEDURE: General anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Cardiac Resynchronization Therapy Pacing Rate
Status: COMPLETED
Conditions: Cardiac Resynchronization Therapy|Heart Failure|Bi-ventricular Pacing|Sympathetic Activity|Quality of Life
Interventions: PROCEDURE: DDD-80|PROCEDURE: DDD-60
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Does Thiazolidinedione Therapy Improve Endothelial Function and Preserve Renal Function
Status: TERMINATED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Pioglitazone|DRUG: Placebo|DRUG: Nitroglycerin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ESPB vs FICB for Pain Management Following Total Hip Prosthesis Surgery
Status: COMPLETED
Conditions: Knee Osteoarthritis|Knee Disease|Knee Arthritis
Interventions: DRUG: Postoperative analgesia management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of HPV Vaccine Administered Intradermally and Intramuscularly Via Needle-Free Injection System
Status: WITHDRAWN
Conditions: Vaccine Reaction
Interventions: DRUG: Gardasil|DRUG: Gardasil|DRUG: Gardasil|DEVICE: PharmaJet Stratis® Needle-Free Injection System|DEVICE: PharmaJet Tropis® Needle-Free Injection System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of HILT vs LLLT in Treatment of Patients With Achilles Tendinitis or Plantar Fasciitis
Status: COMPLETED
Conditions: Plantar Fascitis|Achilles Tendon Pain
Interventions: DEVICE: High-intensity laser therapy|DEVICE: Low-level Laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Efficacy and Safety of LY01015 and Opdivo® Combined Respectively With Chemotherapy in Advanced or Metastatic Esophageal Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: LY01015|DRUG: Fluorouracil|DRUG: Cisplatin|DRUG: Opdivo®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis Collection
Status: RECRUITING
Conditions: Paraneoplastic Neurological Syndromes or Autoimmune Encephalitis
Interventions: BIOLOGICAL: Collection of biological sample with sera, CSF, buffy coat, PBMC, plasma.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Immunogenicity and Safety of an Adjuvanted HBV Vaccine Compared to Engerix™-B, in a Non-responder Population ≥ 15y
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: HBV-MPL vaccine 208129|BIOLOGICAL: Engerix™-B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Mobile Mindfulness to Improve Psychological Distress After Critical Illness
Status: COMPLETED
Conditions: Psychological Distress|Depression|Anxiety|Post-traumatic Stress Disorder|Informal Caregivers|Family Members
Interventions: BEHAVIORAL: mobile mindfulness|BEHAVIORAL: standard mindfulness|BEHAVIORAL: education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maraviroc on HIV-1 Infected Subjects Who Require Allogeneic Hematopoietic Cell Transplant
Status: WITHDRAWN
Conditions: HIV-1-infection
Interventions: OTHER: For Step 2: Structured treatment interruption|PROCEDURE: Peripheral blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: To Compare the Effect of Liraglutide When Given Together With Metformin With the Effect of Metformin Given Alone and With the Effect of Glimepiride and Metformin Given Together
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: metformin|DRUG: glimepiride|DRUG: placebo|DRUG: placebo|DRUG: liraglutide|DRUG: liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Airtrapping on Sleep and Breathing in Non Invasive Ventilation (NIV) in COPD
Status: COMPLETED
Conditions: COPD|Hypercapnic Respiratory Failure
Interventions: DEVICE: BIPAP ST|DEVICE: Airtrap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Standardization and Optimization of TMS Protocols for the Treatment of PD With Depression or Cognitive Impairment
Status: UNKNOWN
Conditions: TMS Protocols in the Treatment of PD
Interventions: DEVICE: repetitive transcranial magnetic stimulation(rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy and Concurrent Cisplatin Chemotherapy for Locally Advanced or Metastatic Malignant Melanoma
Status: TERMINATED
Conditions: Cancer|Melanoma
Interventions: RADIATION: Radiation Therapy|DRUG: Cisplatin|PROCEDURE: Surgical resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Efficacy of Relatlimab in Relapsed or Refractory B-Cell Malignancies
Status: COMPLETED
Conditions: Hematologic Neoplasms
Interventions: BIOLOGICAL: BMS-986016|BIOLOGICAL: BMS-936558
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase Ib Clinical Study on the Safety, the Tolerability, the Pharmacokinetics and the Efficacy of ScTIL Injection (Gene Modified Tumor Infiltrating Lymphocytes) Alone and in Combination With B Lymphocyte Adjuvant in the Treatment of Digestive System Malignant Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Digestive System Malignant Solid Tumors
Interventions: BIOLOGICAL: ScTIL injection|BIOLOGICAL: ScTIL injection and B lymphocytes adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Neflamapimod on Brain Inflammation in Alzheimer's Disease Patients
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: VX-745|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Older Patients With Newly Diagnosed Breast Cancer or Colon Cancer
Status: TERMINATED
Conditions: Breast Cancer|Cognitive/Functional Effects|Colorectal Cancer|Psychosocial Effects of Cancer and Its Treatment
Interventions: BEHAVIORAL: compliance monitoring|DRUG: systemic chemotherapy|OTHER: medical chart review|OTHER: study of socioeconomic and demographic variables|OTHER: survey administration|PROCEDURE: cognitive assessment|PROCEDURE: psychosocial assessment and care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Galcanezumab for Vestibular Migraine
Status: RECRUITING
Conditions: Vestibular Migraine
Interventions: DRUG: Galcanezumab Prefilled Syringe|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Investigate the Safety, Tolerability, and Immunogenicity of the Novel Antituberculous Vaccine RUTI® Following One Month of Isoniazid Treatment in Subjects With Latent Tuberculosis Infection
Status: COMPLETED
Conditions: Latent Tuberculosis Infection|Tuberculosis
Interventions: BIOLOGICAL: RUTI|BIOLOGICAL: RUTI|BIOLOGICAL: RUTI|BIOLOGICAL: RUTI Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanisms Behind Microvascular Dysfunction in INOCA
Status: NOT_YET_RECRUITING
Conditions: Coronary Microvascular Dysfunction|Ischaemia With Non Obstructed Coronary Arteries
Interventions: DIAGNOSTIC_TEST: [15O]H2O-PET Imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tranexamic Acid for Preventing Postpartum Hemorrhage After Cesarean Section
Status: UNKNOWN
Conditions: Postpartum Hemorrhage， Cesarean Section
Interventions: DRUG: Tranexamic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Time Point of Carboprost Methylate Administration and Perioperative Complications
Status: COMPLETED
Conditions: Artificial Abortion, PONV(Post Operative Nausea and Vomiting)
Interventions: DRUG: early vaginal administration of carboprost methylate|DRUG: delayed vaginal administration of carboprost methylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 3 yr Efficacy & Safety Study of Zoledronic Acid in Post-menopausal Women With Osteoporosis Treated With Zol Acid for 6 Yrs
Status: COMPLETED
Conditions: Post-menopausal Osteoporosis
Interventions: DRUG: Placebo|DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ropivacaine and Bupivacaine in Sphenopalatine Ganglion Block in Sinus Surgery
Status: COMPLETED
Conditions: Functional Endoscopic Sinus Surgery (FESS)
Interventions: DRUG: Bupivacaine|DRUG: Ropivacaine|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: How Many Days Would You Want to Practice a Skill to Achieve it?
Status: COMPLETED
Conditions: Motor Learning
Interventions: DEVICE: Sham TDCS|DEVICE: Anodal TDCS|DEVICE: Transcranial Magnetic Stimulation (TMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hematopoietic Stem Cell Transplantation for the Treatment of Limb Ischemia and Diabetic Neuropathy
Status: COMPLETED
Conditions: Limb Ischemia|Diabetic Neuropathy
Interventions: BIOLOGICAL: Hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Four Escalating Dose Regimens of TPI ASM8 in Patients With Allergic Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: TPI ASM8|DRUG: TPI ASM8|DRUG: TPI ASM8|DRUG: TPI ASM8
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The SIM-SOF Trial for Hepatitis C
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Pegylated Interferon alfa-2b|DRUG: Simeprevir|DRUG: Ribavirin|DRUG: Sofosbuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Trial of SHR6508 in Secondary Hyperparathyroidism
Status: RECRUITING
Conditions: Secondary Hyperparathyroidism
Interventions: DRUG: SHR6508 plus oral placebo tablets|DRUG: Cinacalcet plus intravenous placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Medico-economic Evaluation Comparing Intensity-Modulated Radiation Therapy (IMRT) Performed by Helical Tomotherapy and Dynamic Arc Therapy in Prostate, Cervical and Anal Canal Cancers
Status: COMPLETED
Conditions: Prostate Cancer|Cervical Cancer|Anal Canal Cancers
Interventions: RADIATION: Intensity-Modulated Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study To Evaluate Safety And Tolerability Of Pegaptanib Sodium In Patients With Diabetic Macular Edema
Status: COMPLETED
Conditions: Anti- VGF Inhibitor|Diabetic Macular Edema|Diabetic Retinopathy
Interventions: DRUG: pegaptanib sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-pharmacological Intervention for Colonoscopy
Status: TERMINATED
Conditions: Colonoscopy|Sedation|Hypnosis
Interventions: BEHAVIORAL: hypnosis|DRUG: standard sedation|BEHAVIORAL: Structured attention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: to Evaluate the Effectiveness and Safety of the Tixel® , VS LipiFlow® in the Treatment of Meibomian Gland Dysfunction
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction|Dry Eye Syndromes|Dry Eye
Interventions: DEVICE: Tixel C|DEVICE: LipiFlow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrated Management of Pronation Deformity in Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: DRUG: Botulinum toxin type A|OTHER: Upper extremity orthoses|OTHER: Home exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Curcumin Against Colistin-induced Nephrotoxicity
Status: RECRUITING
Conditions: Acute Kidney Injury|Drug-Induced Nephropathy
Interventions: DRUG: Colistin|DRUG: Curcumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: GnRH Antagonist for Treatment of Early Ovarian Hyperstimulation Syndrome
Status: COMPLETED
Conditions: Ovarian Hyperstimulation Syndrome|Effects of Gonadotropin|Oocyte Maturation
Interventions: DRUG: GnRH antagonist (Cetrorelix)|DRUG: Placebo (saline solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Mirabegron (YM178) on Subjects With Mild or Moderate Hepatic Impairment Compared to Healthy Subjects
Status: COMPLETED
Conditions: Pharmacokinetics|Healthy Subjects|Mild and Moderate Hepatic Impairment
Interventions: DRUG: mirabegron
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PROACT - Pre-Operative Arimidex Compared To Tamoxifen
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: ARIMIDEX (anastrazole)|DRUG: NOLVADEX (tamoxifen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3154207 on Sleep in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3154207|DRUG: Placebo|DRUG: Modafinil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of a Large Family With Congenital Mirror Movements : From Underlying Pathophysiology to Culprit Gene Identification PROJET " MOMIC "
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: healthy volunteers|OTHER: Kallmann|OTHER: Congenital Mirror Movement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Contrasting the Brain Effects of Risperidone and Invega With Functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET) Scanning
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DRUG: Risperidone|DRUG: Paliperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cereset Research Long-Term Healthcare Worker Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Stress|Anxiety|Autonomic Dysregulation|Acoustic Stimulation|Hyperarousal|Health Personnel
Interventions: DEVICE: Cereset Research
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Quadratus Lumborum Block After Living Donor Kidney Transplantation
Status: COMPLETED
Conditions: Analgesia
Interventions: PROCEDURE: Transmuscular quadratus lumborum block|PROCEDURE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of BIBW 2948 BS for HandiHaler® in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Low dose of BIBW 2948 BS for oral inhalation|DRUG: Medium dose of BIBW 2948 BS for oral inhalation|DRUG: High dose of BIBW 2948 BS for oral inhalation|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Anti-platelet Factor 4/Heparin Antibodies in Hemodialysis Patients
Status: TERMINATED
Conditions: End Stage Renal Disease
Interventions: DEVICE: GORE® Hybrid Vascular Graft|DEVICE: Non-heparin bonded synthetic graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of the Safety and Contraceptive Efficacy of C31G Compared to Conceptrol®
Status: COMPLETED
Conditions: Pregnancy
Interventions: DRUG: C31G|DRUG: nonoxynol-9 (N-9)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Video Assisted Thoracic Surgery (VATS) Fissure Completion Prior to Zephyr® Endobronchial Valve Insertion
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Emphysema
Interventions: PROCEDURE: Video-assisted thoracoscopic surgery (VATS) fissure completion|DEVICE: Zephyr Valve insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diaphragmatic Mobility In Ventilated Assisted Patients
Status: COMPLETED
Conditions: Ventilation Therapy; Complications
Interventions: OTHER: Diaphragmatic mobility|OTHER: Chest Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploring the Effectiveness to Web-based Exercise Among Community-dwelling Adults With High Body Fat
Status: NOT_YET_RECRUITING
Conditions: Adherence, Treatment|Exercise
Interventions: BEHAVIORAL: web-based aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Arterial Ablation for the Treatment of Type 2 Diabetes Mellitus and Its Comorbidities
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Hypertension
Interventions: COMBINATION_PRODUCT: Neurotronic Infusion Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cetuximab, Docetaxel, Cisplatin, and Radiation Therapy in Treating Patients With Locally Advanced Esophageal Cancer That Can Be Removed by Surgery
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: BIOLOGICAL: cetuximab + docetaxel + cisplatin|BIOLOGICAL: Treatment level 1|BIOLOGICAL: Treatment level 2|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: INAPEN Protocol for Impact of Breakfast Improvement
Status: UNKNOWN
Conditions: Hospital Undernutrition|Malnutrition|Nutritional Deficiency
Interventions: DIETARY_SUPPLEMENT: Addition of protein (milky food in the breakfast)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Role of Consumption and Anticipation in Dopamine Release to Food Reward
Status: UNKNOWN
Conditions: Healthy|Food Reward
Interventions: BEHAVIORAL: Anticipatory + consummatory food reward|BEHAVIORAL: Consummatory food reward
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety Study of Pembrolizumab (MK-3475) in Participants With Advanced Recurrent Ovarian Cancer (MK-3475-100/KEYNOTE-100)
Status: COMPLETED
Conditions: Ovarian Neoplasms
Interventions: BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Navigated Repetitive Transcranial Magnetic Stimulation in Improving Motor Rehabilitation in Participants With Brain Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Brain Neoplasm
Interventions: OTHER: Questionnaire Administration|PROCEDURE: Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Management of Cisplatin-Ineligible Patients With Metastatic Bladder Cancer and The Role of Geriatric Assessments
Status: RECRUITING
Conditions: Bladder Cancer|Metastatic Bladder Cancer|Unresectable Bladder Carcinoma|Urothelial Carcinoma
Interventions: BEHAVIORAL: Geriatric-8 Survey|BEHAVIORAL: National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy Bladder Symptom Index-18 (FBISI-18)|BEHAVIORAL: Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE®)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Resident Surveillance of Pediatric Patient Developmental Status at the Two Month Preventive Care Visit
Status: COMPLETED
Conditions: Growth & Development|Child Development|Internship and Residency|Education, Medical|Developmental Disabilities
Interventions: PROCEDURE: performance feedback with an educational module
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes Treated With Once-daily Basal Insulin With or Without Metformin
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: Cagrilintide|DRUG: Semaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decompression Intervention of Variceal Rebleeding Trial (DIVERT)
Status: COMPLETED
Conditions: Esophageal and Gastric Varices|Liver Cirrhosis
Interventions: PROCEDURE: Transjugular Intrahepatic Portosystemic Shunt (TIPS)|PROCEDURE: Distal Splenorenal Shunt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation of Mirvetuximab Soravtansine (IMGN853) in Women With Folate Receptor-α Positive Endometrial Cancer
Status: RECRUITING
Conditions: Endometrial Cancer
Interventions: DRUG: IMGN853
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HEC53856 Phase Ib Study in Patients With Non-dialysis Renal Anemia
Status: UNKNOWN
Conditions: Chronic Kidney Diseases|Renal Anemia
Interventions: DRUG: HEC53856|DRUG: Roxadustat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Phase I Clinical Study of HIVAC-1e and Smallpox (Vaccinia) Vaccines in Previously (Vaccinia) Vaccinated and Unvaccinated Volunteers
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: Smallpox Vaccine|BIOLOGICAL: HIVAC-1e|BIOLOGICAL: gp160 Vaccine (MicroGeneSys)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Galactose Mediated Glycogen Resynthesis
Status: COMPLETED
Conditions: Exercise
Interventions: OTHER: Glucose alone|OTHER: Galactose alone|OTHER: Glucose and galactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Monitoring and Evaluation of Micronutrients (Sprinkles) Project
Status: COMPLETED
Conditions: Anemia
Interventions: DIETARY_SUPPLEMENT: SPRINKLES|BEHAVIORAL: Nutrition education
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Cerebrolysin on Motor Recovery in Patients With Subacute Stroke
Status: COMPLETED
Conditions: Cerebrolysin
Interventions: DRUG: porcine brain peptide (Cerebrolysin)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: APAP-CYS Protein Adduct Concentrations in Patients With Liver-Directed Therapy Intended to Treat Hepatic Tumors
Status: WITHDRAWN
Conditions: Acetaminophen Exposure
Interventions: DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study to Investigate Relative Bioavailability of Two Different Dosage Forms for Tozorakimab Via Subcutaneous Administration in Healthy Volunteers
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Participants
Interventions: BIOLOGICAL: Tozorakimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra- Versus Extraplexic Catheter Placement for Continuous Interscalene Brachial Plexus Block
Status: COMPLETED
Conditions: Shoulder Pain|Regional Anesthesia Morbidity|Shoulder Arthritis
Interventions: PROCEDURE: Intraplexic catheter location (Contiplex® C, B. Braun Melsungen, AG)|PROCEDURE: Extraplexic catheter location (Contiplex® C, B. Braun Melsungen, AG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Follow Ups of Parents With Infants With Cleft Lip and Palate
Status: COMPLETED
Conditions: Cleft Lip|Cleft Palate
Interventions: OTHER: Cleft lip and palate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Superficial+Deep Vs. Deep Serratus Anterior Plan Block in Video-Assisted Thoracic Surgery
Status: COMPLETED
Conditions: Analgesia
Interventions: OTHER: Group Superficial+Deep Serratus Anterior Plan Block|OTHER: Group Deep Serratus Anterior Plan Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Evolocumab on Carotid Plaque Composition in Asymptomatic Carotid Artery Stenosis (EVOCAR-1)
Status: ACTIVE_NOT_RECRUITING
Conditions: Carotid Artery Stenosis
Interventions: DRUG: Evolocumab Auto-Injector [Repatha]|DRUG: Placebo Auto-Injector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Moxibustion in Diabetes Peripheral Neuropathy
Status: UNKNOWN
Conditions: Peripheral Neuropathy|Diabetic Neuropathies
Interventions: DEVICE: Moxibustion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Single Ascending-dose Study to Evaluate Safety, Tolerability, and PK of MYMD1 in Healthy Male Adult Subjects
Status: COMPLETED
Conditions: Undefined
Interventions: DRUG: MyMD1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: ACEi ARB Withdrawal in CKD Patients
Status: WITHDRAWN
Conditions: Chronic Kidney Disease|Blood Pressure|Angiotensin-converting Enzyme Inhibitor|Angiotensin Receptor Blockers
Interventions: OTHER: Continuation of ACEi and/or ARBs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open, Single-center Clinical Study of Surufatinib Combined With Temozolomide and S-1 in the First-line Treatment of Advanced Neuroendocrine Tumors
Status: NOT_YET_RECRUITING
Conditions: Neuroendocrine Tumors
Interventions: DRUG: Surufatinib Combined With Temozolomide and S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Effect of Norepinephrine Versus Vasopressin on the Pulmonary Circulation in Cardiac Surgery Patients:
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiac Disease
Interventions: DRUG: Norepinephrine|DRUG: Vasopressin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transverse Coloplasty vs. Side-to-end Anastomosis Following Low Anterior Resection (LAR): CSAR Trial
Status: UNKNOWN
Conditions: Rectal Cancer|Rectal Neoplasms|Rectal Tumors|Fecal Incontinence
Interventions: PROCEDURE: Side-to-End Anastomosis|PROCEDURE: Transverse Coloplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hybrid Approach to Unilateral vs. Bilateral Upper Limb Rehabilitation in Subacute and Chronic Stroke
Status: WITHDRAWN
Conditions: Cerebrovascular Accident
Interventions: BEHAVIORAL: Unilateral Hybrid (InMotion3 plus CIT) Intervention|BEHAVIORAL: Bilateral Hybrid (BMT plus BAT) Intervention|BEHAVIORAL: Conventional Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of HIIT Versus MCT on Cardiorespiratory Fitness in PPMS
Status: UNKNOWN
Conditions: Primary Progressive Multiple Sclerosis|Exercise|Cardiorespiratory Fitness
Interventions: BEHAVIORAL: HIIT|BEHAVIORAL: MCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Identification and Treatment of Clinically Silent Catheter-Related Deep Vein Thrombosis in Children With Cancer
Status: TERMINATED
Conditions: Childhood Cancer|Central Venous Catheters|Deep Vein Thrombosis|Catheter-related Infection|Catheter-related Occlusion
Interventions: DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Subcutaneous Injection of Botulinum Toxin A on Chronic Wound Pain in Lower Extremities
Status: COMPLETED
Conditions: Chronic Pain|Lower Extremity Wound
Interventions: DRUG: Botulinum Toxin A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Elastography of Transplanted Kidney (GREFFE_ELASTO IRM)
Status: COMPLETED
Conditions: Interstitial Fibrosis/Tubular Atrophy of Transplanted Kidneys
Interventions: DEVICE: MRE exam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Capacitive and Resistive Electric Transfer Therapy in Chronic Ankle Instability Patients
Status: COMPLETED
Conditions: Chronic Ankle Instability|Capacitive and Resistive Electric Transfer Therapy
Interventions: OTHER: Capacitive and Resistive Electric Transfer Therapy|OTHER: Balance Training|OTHER: Balance Training Combined with Capacitive and Resistive Electric Transfer Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: S1 Plus Docetaxel Versus Capecitabine Plus Docetaxel First-line Treatment in Patients With Advanced Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer Recurrent
Interventions: DRUG: S1 plus Docetaxel|DRUG: Capecitabine plus Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of the General Practitioners and Diabetes Specialists Co-management Model for Patients With Type 2 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Type2diabetes
Interventions: BEHAVIORAL: General Practitioners and Diabetes Specialists Co-management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Hybrid Type 2 Trial of Trauma-Focused Cognitive Behavioral Therapy and a Pragmatic Individual-Level Implementation Strategy
Status: RECRUITING
Conditions: Evidence-Based Practices|CBT|School Health Services|Trauma, Psychological
Interventions: BEHAVIORAL: Beliefs and Attitudes for Successful Implementation in Schools (BASIS)|BEHAVIORAL: Trauma-Focused Cognitive-Behavioral Therapy|BEHAVIORAL: Treatment as Usual|BEHAVIORAL: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pulmonary Condensate: Non-invasive Evaluation of Pulmonary Involvement in Asthma and Cystic Fibrosis.
Status: RECRUITING
Conditions: Bronchial Asthma|Pulmonary Cystic Fibrosis
Interventions: DIAGNOSTIC_TEST: Collection of breath condensate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Dosing Time and Meal on IN-105 (Insulin Tregopil) PK and PD
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: IN-105 (Insulin Tregopil)|OTHER: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Novel Urinary Genomic and Metablomic Markers in Diagnosis of Bladder Cancer in Patients With Hematuria
Status: COMPLETED
Conditions: Hematuria|Bladder Cancer
Interventions: DIAGNOSTIC_TEST: Xpert Bladder Cancer Monitor (Xpert Monitor) test and assay of urinary metabolomics (gene expression of CRAT and SLC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Evaluation on HA Coated Dynamic Hip Screws for Trochanteric Femoral Fractures
Status: COMPLETED
Conditions: Intertrochanteric Fractures
Interventions: DEVICE: Dynamic Hip Screw with HA-coating (Hiploc)|DEVICE: Dynamic Hip Screw without coating (Hiploc)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Safety and Tolerability of Different Formulations and Dose Strengths of Quarterly Risperidone (QUAR) in Patients With Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: Oral risperidone; QUAR F1/2, Dose 1 - Gluteal|DRUG: Oral risperidone; QUAR F1/2, Dose 2 - Gluteal|DRUG: Oral risperidone; QUAR F1/2, Dose 3 - Gluteal|DRUG: Oral risperidone; QUAR F1/2, Dose 3 - Deltoids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Support Group Program in Improving Quality of Life in Underserved Urban Latina Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Carcinoma|Cancer Survivor
Interventions: OTHER: Informational Intervention|OTHER: Informational Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Support Group Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ligation of Intersphincteric Fistula Tract (LIFT) Procedure Versus Use of an Anal Fistula Plug for Anal Fistula Repair
Status: UNKNOWN
Conditions: Anal Fistula
Interventions: PROCEDURE: Ligation of intersphincteric fistula track procedure|PROCEDURE: anal fistula plug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial on the Effectiveness of Traditional Chinese Medicinal Mixture in Parkinson Disease
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: DRUG: Traditional Chinese Medicinal Mixture (composed of Roucongrong and adjuvant)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Shape and Surface Treatment of the Transmucosal Abutments on Peri-implant Health.
Status: COMPLETED
Conditions: Edentulous; Alveolar Process, Atrophy
Interventions: DEVICE: dental implant with transepithelial abutments manufactured by Galimplant Dental System (Spain)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Helping Men Adhere to Sexual Rehabilitation Following Prostate Cancer Surgery
Status: RECRUITING
Conditions: Prostate Cancer|Erectile Dysfunction
Interventions: BEHAVIORAL: questionnaires|BEHAVIORAL: three in-person sessions|BEHAVIORAL: monthly phone calls|BEHAVIORAL: Acceptance and Commitment Therapy for Erectile Dysfunction (ACT-ED)|BEHAVIORAL: Enhanced Monitoring and Education (EME)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial Investigating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Subcutaneously Administered NNC0148-0287 (Insulin 287) in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Type 2 Diabetes Mellitus
Interventions: DRUG: Insulin icodec|DRUG: insulin degludec|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: High Intensity Cycling Before SCUBA Diving Reduces Post-decompression Microparticle Production and Neutrophil Activation
Status: COMPLETED
Conditions: Decompression Sickness|SCUBA Diving
Interventions: OTHER: High intensity exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Naproxen Sodium/ASA Platelet Study
Status: COMPLETED
Conditions: Hematology
Interventions: DRUG: Naproxen Sodium (Aleve, BAY117031)|DRUG: Acetylsalicylic Acid (Aspirin, BAYE4465)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT