pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis
Status: RECRUITING
Conditions: Intracranial Arteriosclerosis|Stroke
Interventions: DRUG: Ticagrelor + Aspirin|DRUG: Rivaroxaban + Aspirin|DRUG: Clopidogrel + Aspirin|OTHER: Risk Factor Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mindfulness Meditation Combined With Progressive Muscle Relaxation Training for Uremic Sarcopenia
Status: COMPLETED
Conditions: Hemodialysis Patients With Sarcopenia
Interventions: BEHAVIORAL: The mindfulness meditation combined with progressive muscle relaxation training .
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Aprepitant for CINV in Patients With Lung Cancer Receiving Multiple-day Cisplatin Chemotherapy
Status: UNKNOWN
Conditions: Chemotherapy-Induced Nausea and Vomiting|Lung Cancer
Interventions: DRUG: Aprepitant|DRUG: Palonosetron|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Does Instruction on Cognitive Aid Use Improve Performance and Retention of Skills?
Status: COMPLETED
Conditions: Long-term Retention of Advanced Cardiac Life Support Skills
Interventions: OTHER: Standard Simulation Based ACLS Refresher Teaching|OTHER: Cognitive Aid based ACLS Refresher training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: RESTORE ME -- RCT of Oxaloacetate on Improving Fatigue in ME/CFS
Status: ENROLLING_BY_INVITATION
Conditions: Myalgic Encephalomyelitis|Chronic Fatigue Syndrome|Fatigue
Interventions: OTHER: Placebo|OTHER: Medical Food - Anhydrous Enol-Oxaloacetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Induction Chemotherapy Combined With Immunotherapy Followed by Concurrent Chemoradiation in Advanced Cervical Cancer
Status: RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: Neoadjuvant Therapy|RADIATION: CCRT|RADIATION: Brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Tobacco Use Treatment for PLWHA
Status: RECRUITING
Conditions: HIV/AIDS|Nicotine Dependence
Interventions: DRUG: Varenicline|DRUG: Nicotine patch|BEHAVIORAL: Standard treatment|BEHAVIORAL: Standard treatment + Managed Problem Solving (MAPS) adherence intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Ascending Single Oral Doses of EDP-322 in Nonfasting and Fasting Healthy Volunteers
Status: COMPLETED
Conditions: Skin and Soft Tissue Infections|Methicillin-resistant Staphylococcus Aureus
Interventions: DRUG: EDP-322
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Decompensation of Pulmonary Hypertension
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension, Pulmonary|Biomarkers
Interventions: OTHER: A biobank will be created from blood samples taken at admission, days 3 and days 7
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Inverted Internal Limiting Membrane Flap Technique for Macular Hole Retinal Detachment in Highly Myopic Eyes
Status: COMPLETED
Conditions: Macular Hole Retinal Detachment
Interventions: PROCEDURE: Vitrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: FT538 in Combination With Daratumumab in AML Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Myeloid Leukemia|Monocytic Leukemia
Interventions: DRUG: Daratumumab/rHuPH20|DRUG: FT538|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IBS Skin Patch Test Food Allergy Study
Status: RECRUITING
Conditions: Irritable Bowel Syndrome
Interventions: OTHER: True avoidance diet|OTHER: Sham avoidance diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SEA-SIDE: Sirolimus Versus Everolimus-eluting Stent Randomized Assessment in Bifurcated Lesions and Clinical SIgnificance of Residual siDE-branch Stenosis
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Stenosis
Interventions: DEVICE: Sirolimus eluting stent|DEVICE: Everolimus eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of NKTR-181 in Opioid-Naive Subjects With Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain|Chronic Pain
Interventions: DRUG: NKTR-181 BID tablets|DRUG: Placebo to match NKTR-181 BID tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability of AB680 in Participants With Gastrointestinal Malignancies
Status: RECRUITING
Conditions: Advanced Pancreatic Cancer
Interventions: DRUG: AB680|DRUG: Zimberelimab|DRUG: Nab-paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Of Dexmedetomidine, Fentanyl And Lignocaine In Attenuation Of Hemodynamic Response To Direct Laryngoscopy And Intubation In Patient Undergoing Laparoscopic Cholecystectomy
Status: UNKNOWN
Conditions: Laparoscopic Cholecystectomy
Interventions: DRUG: dexmedetomidine|DRUG: fentanyl|DRUG: lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Mitral Annuloplasty Rings RCT
Status: UNKNOWN
Conditions: Degenerative Mitral Valve Disease
Interventions: DEVICE: Carpentier Edwards Physio 2 Complete flexible mitral ring|DEVICE: Simplici T Partial flexible mitral annuloplasty ring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of CBX-12 in Subjects With Advanced or Metastatic Refractory Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor, Adult|Epithelial Ovarian Cancer|Small Cell Lung Carcinoma|Breast Cancer|Colorectal Cancer|Pancreas Cancer|Appendix Cancer|Non-small Cell Lung Cancer|Gastric Cancer|Esophagus Cancer|Urothelial Carcinoma|Sarcoma
Interventions: DRUG: CBX-12
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of RO4998452 in Type 2 Diabetes Patients With Varying Degrees of Renal Impairment
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: RO4998452
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Immunotherapy for Resectable Gastric Cancer
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: SHR1210|DRUG: Apatinib|DRUG: S1|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Hypofractionated Radio-chemotherapy With Gemcitabine Plus Oxaliplatin for Unresectable Nonmetastatic Locally Advanced Pancreatic Cancer.
Status: COMPLETED
Conditions: Unresectable Pancreatic Cancer|Nonmetastatic Pancreatic Cancer|Locally Advanced Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Oxaliplatin|RADIATION: Hypofractionated RT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of 68Ga-Pentixafor PET/CT in Primary Aldosteronism and Pre-postoperative of SAAE
Status: RECRUITING
Conditions: Positron-Emission Tomography
Interventions: DIAGNOSTIC_TEST: 68Ga-Pentixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Antazoline in Comparison to Propafenone in Pharmacological Cardioversion of Atrial Fibrillation.
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DRUG: Antazoline|DRUG: Propafenone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Bimatoprost/Timolol Fixed Combination in Patients Wtih Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Ocular Hypertension
Interventions: DRUG: bimatoprost/timolol fixed combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of the Efficacy and Safety of CSF-1 in the Temporary Correction of Presbyopia (NEAR-2)
Status: COMPLETED
Conditions: Presbyopia
Interventions: DRUG: CSF-1|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reduced-target Resection After Induction Chemotherapy in Resectable Recurrent Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma|De-escaltion Therapy
Interventions: PROCEDURE: Reduced-target resection|PROCEDURE: Full-target resection|DRUG: Adjuvant immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Proprietary Blend of Herbal Extract Supplement on Cellular Detoxification, Inflammation, and Cumulative Cognitive Index as Well as Gene Expression in Middle-Aged Adult Women
Status: COMPLETED
Conditions: Anti Aging
Interventions: DIETARY_SUPPLEMENT: Vitality product AM + Vitality product PM|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Patient Decision-making About Precision Oncology in Veterans With Advanced Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer|Advanced Prostate Carcinoma
Interventions: OTHER: Participant Surveys|OTHER: Mobile app
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Combined Model Based on Spleen Stiffness, Liver Stiffness and Platelets for Assessing Portal Hypertension in Compensated Cirrhosis (CHESS2202)
Status: RECRUITING
Conditions: Portal Hypertension
Interventions: DIAGNOSTIC_TEST: Hepatic venous pressure gradient
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 2NN & CHARM Long-Term Follow-up Study
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: stavudine|DRUG: lamivudine|DRUG: nevirapine|DRUG: efavirenz|DRUG: trizivir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Study of Dulanermin Administered in Combination With Camptosar®/Erbitux® Chemotherapy or FOLFIRI (With or Without Bevacizumab) in Subjects With Previously Treated Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: FOLFIRI regimen|DRUG: bevacizumab|DRUG: cetuximab|DRUG: dulanermin|DRUG: irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TBTC Study 31: Rifapentine-containing Tuberculosis Treatment Shortening Regimens
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: rifapentine|DRUG: rifapentine and moxifloxacin|DRUG: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Automated vs Conventional Perioperative Glycemic Control in Diabetic Patients Undergoing Cardiopulmonary Bypass Surgery
Status: COMPLETED
Conditions: Diabetes|Cardiopulmonary Bypass
Interventions: DEVICE: Space Glucose Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of LY2062430 on the Progression of Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: LY2062430|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Real World Effectiveness Study of Pegcetacoplan in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)
Status: RECRUITING
Conditions: Paroxysmal Nocturnal Hemoglobinuria
Interventions: DRUG: Pegcetacoplan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: How Does the Addition of Adductor Canal Block to Local Infiltration Affect Recovery in Patients Undergoing Total Knee Arthroplasty? A Feasibility Study.
Status: COMPLETED
Conditions: Knee Osteoarthritis|Arthritis Knee|Knee Disease|Opioid Use
Interventions: PROCEDURE: Adductor Canal Block|PROCEDURE: Periarticular Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Removal of Dermal Exposure to Phthalate Ester by Hand Washing
Status: COMPLETED
Conditions: Environmental Exposure|Exposure to Pollution
Interventions: BEHAVIORAL: handwashing with soap|BEHAVIORAL: handwashing with water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of LCZ696 in Comparison to Olmesartan in Asian Patients With Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: LCZ696|DRUG: Olmesartan|DRUG: Placebo of LCZ696|DRUG: Placebo of Olmesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multimodal Analgesic Treatment Versus Traditional Morphine Analgesia After Cardiac Surgery
Status: COMPLETED
Conditions: Analgesia|Postoperative Pain
Interventions: DRUG: Ibuprofen|DRUG: Gabapentin|DRUG: Morphine|DRUG: Paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proof-of-concept Study for SAR445088 in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Interventions: DRUG: SAR445088 (IV)|DRUG: SAR445088 (SC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Validation of a Cloak Shape Device for Sham Pediatric Tuina
Status: COMPLETED
Conditions: Child
Interventions: DEVICE: Cloak Shape Device for Sham Tuina|DEVICE: Cloak Shape Device for Genuine Tuina
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures
Status: COMPLETED
Conditions: Pain, Postoperative|Ankle Fractures
Interventions: DRUG: Ropivacaine|DRUG: Epinephrine|DRUG: Morphine|DRUG: 0.9% sodium chloride solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Significance of Synbiotics on Inflammation and Proliferation of Colonic Mucosa
Status: COMPLETED
Conditions: Inflammation
Interventions: DIETARY_SUPPLEMENT: Lactobacillus|DIETARY_SUPPLEMENT: Bifidobacterium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Consistency of Cardiac Output Measurements by Different Methods in VA-ECMO Patients
Status: UNKNOWN
Conditions: Extracorporeal Membrane Oxygenation
Interventions: DIAGNOSTIC_TEST: Trendelenburg Maneuver|DIAGNOSTIC_TEST: dobutamine stress test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assess the Immunogenicity & Safety of 2 Doses of Oral Live Attenuated Human Rota(HRV)Vaccine in Healthy Infants in India
Status: COMPLETED
Conditions: Infections, Rotavirus
Interventions: BIOLOGICAL: Live attenuated human rotavirus vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: PREVENTION
Clinical trial: Study of Surufatinib Single Agent or Surufatinib Combined With Toripalimab in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: Surufatinib|DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: etoposide|DRUG: topotecan hydrochloride|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trimetazidine in Pulmonary Artery Hypertension
Status: UNKNOWN
Conditions: Pulmonary Artery Hypertension
Interventions: DRUG: Trimetazidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Amphotericin Versus Posaconazole for Pulmonary Mucormycosis
Status: RECRUITING
Conditions: Mucormycosis; Pulmonary (Etiology)
Interventions: DRUG: Posaconazole 600 mg followed by posaconazole 300 mg once daily|DRUG: Liposomal Amphotericin B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Angiotensin Inhibitors During the Perioperative Period
Status: TERMINATED
Conditions: Surgery|Angiotensin Hypertension|Perioperative Complication
Interventions: DRUG: Perioperative withdrawal of angiotensin converting enzyme inhibitors and angiotenin receptor blockers|DIAGNOSTIC_TEST: Blood draw|BEHAVIORAL: Diary to register drug adherence|BEHAVIORAL: Quality of life questionnaire|BEHAVIORAL: WHODAS questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy Followed By Donor Stem Cell Transplant in Treating Patients With Hemophagocytic Lymphohistiocytosis
Status: UNKNOWN
Conditions: Nonneoplastic Condition
Interventions: BIOLOGICAL: anti-thymocyte globulin|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: cyclosporine|DRUG: dexamethasone|DRUG: etoposide|DRUG: methotrexate|DRUG: mycophenolate mofetil|DRUG: therapeutic hydrocortisone|OTHER: laboratory biomarker analysis|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Behavioral Effects of Drugs (Inpatient): 43 (Opioids, Cocaine, n-Acetylcysteine)
Status: RECRUITING
Conditions: Cocaine Use Disorder|Opioid Use Disorder
Interventions: DRUG: n-acetylcysteine|DRUG: Hydromorphone|DRUG: Placebo n-acetylcystine|DRUG: Placebo hydromorphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: ST2 for the Management of Heart Failure - STADE-HF
Status: COMPLETED
Conditions: Heart Failure|Diastolic Heart Failure|Systolic Heart Failure Stage C
Interventions: OTHER: Conventional strategy|OTHER: ST2-guided strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study With Intraperitoneal Cisplatin and Doxorubicin in Recurrent Ovarian Cancer and Peritoneal Carcinomatosis
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Cisplatin and doxorubicin|PROCEDURE: Cisplatin and doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Safety and Effectiveness of MBX-102 in Type 2 Diabetes Patients With Poor Glycemic Control on Metformin
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: MBX-102|DRUG: Placebo|DRUG: Actos|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Tetracycline Drain Reduces Alveolar Osteitis in Third Molar Surgery
Status: COMPLETED
Conditions: Post-Operative Wound Infection
Interventions: DRUG: Tetracyclin ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Physical Rehabilitation Evaluation and Optimal Physical Therapy (PRE-OPT)
Status: RECRUITING
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Physical Therapy: Dependent on Patient's Needs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Drug-Drug Interaction Study To Investigate The Ginkgolides Meglumine Injection To Alter The Pharmacokinetics Of Midazolam
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Midazolam|DRUG: Ginkgolides Meglumine Injection|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Acceptability of Cabotegravir in HIV Uninfected Women in KwaZulu-Natal, South Africa
Status: WITHDRAWN
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: cabotegravir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Irritable Bowel Syndrome (IBS) With Sacral Nerve Stimulation
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DEVICE: Sacral nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial Evaluating the Effectiveness of a Salvia-based Mouthwash in Palliative Care
Status: COMPLETED
Conditions: Terminal Illness|Xerostomia
Interventions: OTHER: Saline mouthwash|OTHER: Salvia mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Safety and Tolerability of Single and Multiple Doses of AZD4831 in Healthy Male Subjects
Status: TERMINATED
Conditions: Cardiovascular Disease
Interventions: DRUG: AZD4831|DRUG: AZD4831 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ropivacaine and Midazolam by Intraarticular vs Epidural Administration in Arthroscopic ACL
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injuries|Anesthesia Injection Site|Knee Injuries
Interventions: DRUG: ropivacaine and midazolam intraarticular administration|DRUG: ropivacaine and midazolam epidural administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neural Response to Food Stimuli: fMRI Changes Following Cognitive Behavioral Therapy for Binge Eating Disorder
Status: COMPLETED
Conditions: Binge Eating Disorder|Overweight and Obesity
Interventions: BEHAVIORAL: Cognitive behavioral therapy|BEHAVIORAL: Waitlist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Arterial Hypertension in Patients With Direct-Acting Antiviral Medications for Hepatitis C Virus Infection
Status: COMPLETED
Conditions: Pulmonary Artery Hypertension|Chronic Hepatitis c
Interventions: DIAGNOSTIC_TEST: transthoracic doppler-echocardiography (TTE)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Zero-ischemia Robot-assisted Partial Nephrectomy Using Near-infrared Fluorescence
Status: UNKNOWN
Conditions: Renal Cancer
Interventions: PROCEDURE: Robot assisted partial nephrectomy super-selective clamping|PROCEDURE: Robot assisted partial nephrectomy with renal artery clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Instillation of Mistletoe
Status: RECRUITING
Conditions: Superficial Bladder Cancer
Interventions: DRUG: abnobaVISCUM 900|DRUG: Mitomycin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electromagnetic Stimulation for the Treatment of Urge Urinary Incontinence and Overactive Bladder
Status: TERMINATED
Conditions: Urinary Incontinence, Urge
Interventions: DEVICE: Electrical Field Stimulation Device|DEVICE: Sham Nerve Stimulation Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acquired Acute Bacterial Pneumonia Due to S. Pneumoniae
Status: COMPLETED
Conditions: Pneumonia, Bacterial
Interventions: DRUG: daptomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: Endotracheal Intubation Using Three Laryngoscopes in Maternal Cardiac Arrest: a Manikin Simulation Study
Status: COMPLETED
Conditions: Cardiac Arrest
Interventions: DEVICE: 15 degree left-lateral tilt wedges|DEVICE: 30 degree left-lateral tilt wedges
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of a Driving Intervention on Safe Community Mobility for Returning Combat Veterans
Status: COMPLETED
Conditions: Traumatic Brain Injury (TBI)|Post Traumatic Stress Disorder (PTSD)
Interventions: BEHAVIORAL: Driving Behavior Interview|OTHER: Clinical Driving Assessment|BEHAVIORAL: Propensity for Angry Driving Scale|BEHAVIORAL: Community Integration Questionnaire|BEHAVIORAL: Satisfaction with Life|BEHAVIORAL: Fitness-to-Drive Screening Measure (FTDS)|PROCEDURE: Simulated Driving Evaluation|PROCEDURE: Driving Safety Education|PROCEDURE: Occupational Therapy Driving Intervention (OT-DI)|PROCEDURE: On-road driving test|PROCEDURE: Driving triggers evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intra-Articular Injection of Etanercept for Moderate and Severe Knee Osteoarthritis
Status: UNKNOWN
Conditions: Osteoarthritis of Knee
Interventions: DRUG: Etanercept|OTHER: Health education, exercise and diet guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Assessment of the Infart-related Artery With Bioactive and Polymer-free Coronary Stents (The FUNCOMBO Trial)
Status: COMPLETED
Conditions: Endothelial Dysfunction|Coronary Microvascular Disease|Myocardial Infarction
Interventions: PROCEDURE: Stent implantation in the infart-related artery in patients with ST elevation myocardial infarction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of the Addition of Morphine Chloride to a Low Dose of Bupivacaine as Intradural Anaesthetic for the Removal Surgery of the Hemorrhoids
Status: COMPLETED
Conditions: Surgical Remove of Hemorrhoids
Interventions: DRUG: Bupivacaine low dose|DRUG: Bupivacaine standard dose|DRUG: Morphine Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Local Application of Lidocaine During Scleral Buckling Under General Anesthesia
Status: UNKNOWN
Conditions: Retinal Detachment
Interventions: DRUG: lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Drug-drug Interaction of Dabigatran and Ticagrelor
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: dabigatran etexilate|DRUG: dabigatran etexilate|DRUG: ticagrelor|DRUG: ticagrelor|DRUG: ticagrelor|DRUG: dabigatran etexilate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NT-501 CNTF Implant for Glaucoma: Safety, Neuroprotection and Neuroenhancement
Status: COMPLETED
Conditions: Glaucoma, Primary Open Angle
Interventions: DRUG: NT-501 CNTF Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity, Safety and Tolerability of the Typhoid Fever Vaccine Candidate M01ZH09 in Healthy Adults
Status: COMPLETED
Conditions: Typhoid
Interventions: BIOLOGICAL: Dose of 5.0 x 10^9 CFU (Cohort 1)|BIOLOGICAL: Dose of 7.5 x 10^9 CFU (Cohort 2)|BIOLOGICAL: Dose of 1.1 x 10^10 CFU (Cohort 3)|BIOLOGICAL: Dose of of 1.7 x 10^10 CFU (Cohort 4)|OTHER: Placebo (Cohorts 1-4 pooled)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact Evaluation of CyberRwanda: A Digital Health Intervention for Adolescents
Status: COMPLETED
Conditions: Pregnancy in Adolescence|Adolescent Health|Health Services Accessibility
Interventions: BEHAVIORAL: CyberRwanda
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Solid Tumor
Interventions: DRUG: Inavolisib|DRUG: Fulvestrant|DRUG: Letrozole|DRUG: Palbociclib|DRUG: Metformin|DRUG: Trastuzumab|DRUG: Pertuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Ventilation Versus Continuous Positive Airway Pressure in Cardiogenic Pulmonary Edema
Status: COMPLETED
Conditions: Cardiogenic Pulmonary Oedema
Interventions: DEVICE: Non-Invasive Ventilation|DEVICE: Continuous Positive AirwayPressure CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postmenopausal Women and Their Endothelium
Status: COMPLETED
Conditions: Postmenopausal Women
Interventions: DRUG: nitrate rich beetroot juice|DRUG: nitrate depleted beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Japanese Study With Rimonabant in Obese Type 2 Diabetic Patients on Diet and Exercise
Status: TERMINATED
Conditions: Obesity|Diabetes Mellitus Type 2
Interventions: DRUG: Rimonabant|DRUG: placebo (for Rimonabant)|OTHER: Diet and exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tofacitinib (Xeljanz) Special Investigation for Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tofacitinib (Xeljanz)|DRUG: Etanercept, other Biologics, Disease-modifying antirheumatic drugs (DMARDs), etc
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo
Status: COMPLETED
Conditions: Pulpitis - Irreversible
Interventions: DRUG: one dose ketorolac 10 mg|DRUG: One dose Diclofenac|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trial on Safety & Performance of TAXUS Element vs. XIENCE Prime Stent in Treatment of Coronary Lesion in Diabetics
Status: COMPLETED
Conditions: Type 2 Diabetes|Coronary Heart Disease
Interventions: DEVICE: TAXUS Element™ Paclitaxel-Eluting Stent System|DEVICE: Xience PRIME Everolimus-Eluting Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Integration of Mindfulness and Acupuncture After Spine Surgery
Status: NOT_YET_RECRUITING
Conditions: Single Level Spinal Fusion|Discetomy|Laminectomy
Interventions: BEHAVIORAL: Mindfulness training|OTHER: Acupuncture|BEHAVIORAL: Enhanced education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Study of Pulsed, Inhaled Nitric Oxide Versus Placebo in Symptomatic Subjects With PAH
Status: TERMINATED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Inhaled Nitric Oxide 75 mcg/kg IBW/hr|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selinexor and HAAG With/Without HMA in Relapsed/Refractory Acute Leukemia (AML) Patients
Status: NOT_YET_RECRUITING
Conditions: Relapsed/Refractory AML
Interventions: DRUG: Selinexor|DRUG: Homoharringtonine|DRUG: Cytarabine|DRUG: Aclacinomycin|DRUG: Granulocyte Colony-Stimulating Factor|DRUG: Decitabine|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension Study in Subjects Who Relapsed After Complete Response on Study KW-0761-001
Status: COMPLETED
Conditions: Peripheral T-cell Lymphoma|Cutaneous T-cell Lymphoma
Interventions: BIOLOGICAL: KW-0761
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety With Albumin-bound Paclitaxel (Abraxane) in the TAC as Neoadjuvant Chemotherapy in Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Abraxane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Doravirine/Islatravir (DOR/ISL) in Pediatric Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Who Are <18 Years of Age and Weigh ≥35 kg (MK-8591A-028)
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: DOR/ISL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ethanol Lock for the Salvage of Infected Long-term Vascular Access
Status: UNKNOWN
Conditions: Bacteremia
Interventions: DRUG: Ethanol-lock therapy|DRUG: Antibiotic-lock
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selective Neoadjuvant Treatment According to Immunohistochemical Subtype for HER2 Negative Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: Docetaxel|DRUG: Exemestane|DRUG: Goserelin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes
Status: RECRUITING
Conditions: Type 1 Diabetes|Diabetic Kidney Disease|Cardiovascular Diseases|Endothelial Dysfunction|Insulin Sensitivity
Interventions: DRUG: Metformin Hcl 1000Mg Tab|DRUG: Aminohippurate Sodium 20 % Injection|DRUG: Iohexol 300 Mg/mL Injectable Solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias, Lymphomas or Solid Tumors
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Accelerated Phase Chronic Myeloid Leukemia|Blast Phase Chronic Myeloid Leukemia|Chronic Phase Chronic Myeloid Leukemia|Acute Lymphoblastic Leukemia|Acute Lymphocytic Leukemia|Leukemia|Lymphoma|Solid Tumors
Interventions: DRUG: Ponatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Bend Beauty's Anti-Aging Formula on Inflammatory Markers
Status: WITHDRAWN
Conditions: Inflammation|Skin Abnormalities|Skin Pigment|Inflammatory Response|Skin Inflammation
Interventions: DIETARY_SUPPLEMENT: Anti-Aging Formula|DIETARY_SUPPLEMENT: Control Fish Oil|OTHER: Inert Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiosurgery Plus NovoTTF-200A for Metastatic Small Cell Lung Cancer to the Brain
Status: TERMINATED
Conditions: Brain Metastases|Small Cell Lung Cancer
Interventions: DEVICE: NovoTTF-200A|RADIATION: Stereotactic Radiosurgery (SRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRO-GLIO: PROton Versus Photon Therapy in IDH-mutated Diffuse Grade II and III GLIOmas
Status: RECRUITING
Conditions: Oligodendroglioma|Oligodendroglioma, Anaplastic|Diffuse Astrocytoma, IDH-Mutant
Interventions: RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Androgen Ablation Therapy on Cognitive Functioning and Functional Status in Men With Prostate Cancer Age 65 and Older
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: BEHAVIORAL: Questionaires|BEHAVIORAL: Questionaires|DEVICE: fMRI scan (optional)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Investigate Safety, Pharmacokinetic (PK), Pharmacodynamic (PD) and Clinical Activity of Trametinib in Subjects With Cancer or Plexiform Neurofibromas and Trametinib in Combination With Dabrafenib in Subjects With Cancers Harboring V600 Mutations
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Trametinib|DRUG: Dabrafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pre-operative Window Study of Letrozole Plus PR Agonist (Megestrol Acetate) Versus Letrozole Alone in Post-menopausal Patients With ER-positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Megestrol Acetate 40 MG|DRUG: Megestrol Acetate 160 MG|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ZW25 (Zanidatamab) With Palbociclib Plus Fulvestrant in Patients With HER2+/HR+ Advanced Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: HER2+/HR+ Breast Cancer
Interventions: DRUG: ZW25 (Zanidatamab)|DRUG: Palbociclib|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mitoxantrone and Clofarabine for Treatment of Recurrent NHL or Acute Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Acute Myelogenous Leukemia|Lymphoblastic Lymphoma|Diffuse Large B-cell Lymphoma|Burkitt Lymphoma/Leukemia
Interventions: DRUG: Clofarabine|DRUG: Mitoxantrone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Epigastric Pain Syndrome and Postprandial Distress Syndrome
Status: WITHDRAWN
Conditions: Functional Dyspepsia|Epigastric Pain Syndrome|Post Prandial Distress Syndrome
Interventions: RADIATION: gastric scintigraphy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nevirapine Clearance After Short-term Highly Active Antiretroviral Therapy (HAART) for Prevention of Mother to Child Transmission of HIV (PMTCT)
Status: COMPLETED
Conditions: NVP Plasma Level|NVP Related Mutation|3TC Related Mutation
Interventions: DRUG: AZT/3TC 2 weeks after delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: RHEUPP - A Rheumatological Follow-up Management App
Status: NOT_YET_RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DEVICE: RHEUPP App|OTHER: Usual Follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Clinical Study to Assess the Effects of JoyRise Recovery Powder on Mitigating Alcohol Aftereffects.
Status: COMPLETED
Conditions: Alcohol Aftereffects|Anxiety|Cognitive Impairment
Interventions: DIETARY_SUPPLEMENT: JoyRise Recovery Powder|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PEARL PET-based Adaptive Radiotherapy Clinical Trial
Status: UNKNOWN
Conditions: Oropharyngeal Cancer
Interventions: PROCEDURE: PET-CT scans|PROCEDURE: Outlining the biological GTVs (bGTV_P and bGTV_iP)|PROCEDURE: Blood samples for cell-free DNA analysis|PROCEDURE: Salivary samples for cell-free DNA analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Weight Gain Using 2 Different Formulations of Megestrol Acetate Oral Suspension for AIDS-related Weight Loss
Status: COMPLETED
Conditions: HIV Infections|Cachexia|Anorexia|AIDS Wasting Syndrome|HIV Wasting Syndrome
Interventions: DRUG: Megestrol acetate oral suspension nanocrystal dispersion 115 mg/mL|DRUG: Megestrol acetate oral suspension 40 mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydronidone Capsules in Long-term Treatment in Patients With Chronic Viral Hepatitis B Liver Fibrosis
Status: RECRUITING
Conditions: Liver Fibrosis
Interventions: DRUG: Hydronidone capsules|DRUG: The placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Purified Vero Rabies Vaccine Serum Free Compared With Reference Purified Vero Rabies Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Rabies
Interventions: BIOLOGICAL: Purified Vero Rabies Vaccine - Serum Free|BIOLOGICAL: Purified inactivated rabies vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Faringomoss Effectiveness in Inhibiting Acute Throat Pain and Discomfort
Status: COMPLETED
Conditions: Spraying Behavior|Mouth Diseases|Throat Diseases|Throat Pain
Interventions: DEVICE: Oral spray 1|DEVICE: Oral spray 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nasal Continuous Positive Airway Pressure (CPAP) Blood Pressure and Vascular Endothelial Growth Factor in Obstructive Sleep Apnea Syndrome
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Continuous positive airway pressure (CPAP)|DEVICE: Sham Continuous positive airway pressure (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT