pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: SPREAD-NET: PRactices Enabling Adapting and Disseminating in the Safety NET
Status: COMPLETED
Conditions: Diabetes Mellitus|Cardiovascular Disease
Interventions: OTHER: Low support|OTHER: Medium support|OTHER: High support|OTHER: Comparison
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: AURORA: Crestor 10mg Versus Placebo in Subjects With End-stage Renal Disease (ESRD)
Status: COMPLETED
Conditions: Renal Failure
Interventions: DRUG: 10mg Rosuvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Comparison of the 1-min Sit-to-Stand Test to the 6-minute Walk Test in the Respiratory Functional Assessment of Pulmonary Fibrosis
Status: RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: OTHER: TLC1_TM6|OTHER: TM6_TLC1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Assess DerMend Moisturizing Bruise Formula in Improving the Appearance of Chronically Aged Forearms and Hands
Status: COMPLETED
Conditions: Purpura
Interventions: DRUG: DerMend Moisturizing Bruise Formula|DRUG: Non-active placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of SUN13837 Injection in Adult Subjects With Acute Spinal Cord Injury (ASCI)
Status: COMPLETED
Conditions: Acute Spinal Cord Injury
Interventions: DRUG: SUN13837 injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Korean Multicenter Registry of ELUVIA Stent for Femoropopliteal Artery Disease (K-ELUVIA Registry)
Status: UNKNOWN
Conditions: Symptomatic Peripheral Artery Disease With Femoropopliteal Lesions|Moderate or Severe Claudication (Rutherford Category 2 or 3)|Critical Limb Ischemia (Rutherford Category 4 or 5)
Interventions: DEVICE: Implantation of Eluvia stent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Folinic Acid Rescue Following MTX GVHD Prophylaxis on Regimen Related Toxicity and Transplantation Outcome
Status: UNKNOWN
Conditions: Graft vs Host Disease|Allogeneic Hematopoietic Cell Transplantation|Mucositis
Interventions: DRUG: Folinic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Epidemiology, Acute Management, and Outcomes of Patients With Sepsis Presenting to a Referral Hospital in Western Kenya
Status: COMPLETED
Conditions: Sepsis|Severe Sepsis|Septic Shock
Interventions: OTHER: WHO algorithm of fluid boluses guided by physical examination|OTHER: Frequent patient monitoring|OTHER: Early administration of empiric antibiotics|OTHER: Oxygen delivery|OTHER: Correction of hypoglycemia|OTHER: Correction of severe anemia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Colonizing Neurogenic Bladders With Benign Flora
Status: COMPLETED
Conditions: Spinal Cord Injury|Urinary Tract Infection
Interventions: BIOLOGICAL: Insertion of urinary catheters coated with E. coli 83972
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intrapapillary Botulinum Toxin Injection for PREvention of Post-surgical PAncREactic Fistula
Status: RECRUITING
Conditions: Distal Pancreatectomy|Postoperative Pancreatic Fistula
Interventions: DRUG: botulinum toxin injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Activating Behavior for Lasting Engagement After Stroke
Status: COMPLETED
Conditions: Stroke|Physical Activity|Sedentary Lifestyle|Behavior, Health|Physical Disability
Interventions: BEHAVIORAL: Activating Behavior for Lasting Engagement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of Rates and Reasons for Non-Adherence to Anti-Arrhythmic Therapy for Atrial Fibrillation
Status: TERMINATED
Conditions: Atrial Fibrillation|Medication Adherence
Interventions: OTHER: Education and telephone follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Iron Supplementation in Upper Non-variceal Gastrointestinal Bleeding
Status: NOT_YET_RECRUITING
Conditions: GastroIntestinal Bleeding|Anemia
Interventions: DRUG: Oral iron supplementation|DRUG: Intravenous iron supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Consequence of Unilateral Vestibular Loss on Visual Abilities
Status: COMPLETED
Conditions: Vestibular Schwannoma|Visual Impairment|Vestibular Meniere Syndrome
Interventions: DIAGNOSTIC_TEST: orthoptic balance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Treatment Effect of Chinese Herbal Compound Ointment on Atrophic Vaginitis
Status: UNKNOWN
Conditions: Atrophic Vaginitis
Interventions: DRUG: Chinese Herbal Compound Ointment|DRUG: Estriol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Testing Ftorafur (UFT) Associated With Neoadjuvant Radiotherapy Versus Radiotherapy Alone in Rectal Adenocarcinoma
Status: TERMINATED
Conditions: Rectal Cancer|Stage II/III|T3 or T4 (Only Anal Extension) Rectal Cancer|N0-2|M0
Interventions: DRUG: Tegafur and Uracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Ibuprofen and Caffeine in Dental Pain
Status: COMPLETED
Conditions: Pain, Postoperative|Tooth Diseases
Interventions: DRUG: ibuprofen + caffeine|DRUG: ibuprofen|DRUG: ibuprofen|DRUG: caffeine|DRUG: ibuprofen + caffeine|DRUG: placebo|DRUG: placebo|DRUG: caffeine|DRUG: ibuprofen|DRUG: ibuprofen + caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Trial of Home-Based Palliative Care
Status: TERMINATED
Conditions: Cancer|Chronic Obstructive Pulmonary Disease|Heart Failure|Dementia|End Stage Liver Disease|End Stage Renal Disease|Neuromuscular Diseases
Interventions: OTHER: Tech-supported HBPC|OTHER: Standard HBPC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Examining the Efficacy of the T-STEP
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: TEACCH School Transition to Employment and Postsecondary Education (T-STEP)|BEHAVIORAL: Counseling Services Alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Atomized Dexmedetomidine on Lung Function in Patients With Chronic Obstructive Pulmonary Disease
Status: RECRUITING
Conditions: Respiratory Function Tests|Chronic Obstructive Pulmonary Disease|Dexmedetomidine
Interventions: DRUG: Dexmedetomidine 0.5 μg/kg|DRUG: Dexmedetomidine 1 μg/kg|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Duration of Effect of Biotene Spray in Patients With Dry Mouth
Status: COMPLETED
Conditions: Dry Mouth
Interventions: DEVICE: Biotene|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial With Adipose Tissue Stem Cells on Biological Matrix for the Treatment of Venous Ulcer of the Lower Limbs
Status: RECRUITING
Conditions: Venous Ulcer
Interventions: BIOLOGICAL: Bioengineered Artificial Mesenchimal Sheet (BAMS)|PROCEDURE: Standard treatment (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous vs. Intraosseous Vascular Access During Out-of-Hospital
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiac Arrest
Interventions: DEVICE: Intraosseous access|DEVICE: Intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Minimally Invasive Surgical Technique in Accelerating Orthodontic Treatment
Status: COMPLETED
Conditions: Malocclusion, Angle Class II
Interventions: PROCEDURE: Piezosurgery|RADIATION: ER:YAG laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Soy Formula Feedings in Healthy, Term Infants
Status: COMPLETED
Conditions: Gastrointestinal Tolerance
Interventions: OTHER: Experimental Infant Formula 1|OTHER: Experimental Infant Formula 2|OTHER: Experimental Infant Formula 3|OTHER: Active Comparator: Control Infant Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Lenalidomide With Gemcitabine in Treatment of Untreated Advanced Carcinoma of the Pancreas
Status: COMPLETED
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: Lenalidomide|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Bias Modification for Youth Anxiety
Status: UNKNOWN
Conditions: Anxiety
Interventions: BEHAVIORAL: Self-Administered, Active Cognitive Bias Modification (CBM)|BEHAVIORAL: Self-Administered, minimally effective attention-control version of the CBM program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Apoptosis Markers in Aggressive Periodontitis
Status: COMPLETED
Conditions: Molar-incisor Pattern Grade C Periodontitis ( Localized Aggressive Periodontitis)|Generalized Grade C Periodontitis (Generalized Aggressive Periodontitis)
Interventions: DIAGNOSTIC_TEST: ELISA assessment of apoptosis markers in gingival crevicular fluid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nasal High Frequency Ventilation in Preterm Infants: A Pilot Study
Status: COMPLETED
Conditions: Infant Respiratory Distress Syndrome|Respiratory Insufficiency|Apnea of Prematurity
Interventions: OTHER: Nasal high frequency ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Investigate Filiation Between Primary and Secondary Lesions in Acne Patients
Status: COMPLETED
Conditions: Acne
Interventions: DRUG: CD0271 0.1%/CD1579 2.5% gel|DRUG: CD0271 0.1%/CD1579 2.5% gel vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of GnRH Agonist Treatment Protocols on Ovarian Reserve
Status: COMPLETED
Conditions: Intracytoplasmic Sperm Injection|GnRH Agonist|Infertility|Ovarian Reserve
Interventions: DRUG: ultrashort GnRHa|DRUG: short GnRHa|DRUG: long GnRHa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mandibular Reconstruction Bone Plate
Status: ENROLLING_BY_INVITATION
Conditions: Mandible Tumor
Interventions: PROCEDURE: Mandibular marginal resection and reconstruction|DEVICE: mandibular osteosynthesis a 2.3mm reconstruction bone plate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Chronic Myelogenous or Acute Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: Filgrastim|DRUG: Busulfan|DRUG: Cyclophosphamide|DRUG: Cyclosporine|DRUG: Decitabine (DAC)|DRUG: Methotrexate|DRUG: Methylprednisolone|DRUG: Tacrolimus|PROCEDURE: Allogeneic Bone Marrow Transplantation|PROCEDURE: Peripheral Blood Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Domatinostat in Combination With Avelumab in Patients With Treatment-naïve Metastatic Merkel Cell Carcinoma (MERKLIN 1)
Status: WITHDRAWN
Conditions: Merkel Cell Carcinoma
Interventions: DRUG: domatinostat in combination with avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial on the Efficacy and Safety of Virgin Coconut Oil Compared to Mineral Oil in the Treatment of Uremic Xerosis
Status: COMPLETED
Conditions: Uremic Xerosis
Interventions: OTHER: Virgin Coconut Oil|OTHER: Mineral Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Combined Vaccination With Quadrivalent Influenza Vaccine and 23-valent Pneumococcal Polysaccharide Vaccine
Status: COMPLETED
Conditions: Influenza and Pneumonia
Interventions: BIOLOGICAL: Combined vaccination with quadrivalent influenza vaccine and 23-valent pneumococcal polysaccharide vaccine|BIOLOGICAL: Separate vaccination with quadrivalent influenza vaccine and 23-valent pneumococcal polysaccharide vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Hydroxychloroquine for the Treatment of Patients With Mild to Moderate COVID-19 to Prevent Progression to Severe Infection or Death
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: Hydroxychloroquine|OTHER: The control group will not receive hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TNM002 in Healthy Adults
Status: COMPLETED
Conditions: Healthy Adult Subjects
Interventions: BIOLOGICAL: TNM002 Dosage 1 (10 μg/kg)|BIOLOGICAL: Placebo|BIOLOGICAL: TNM002 Dosage 2 (35 μg/kg)|BIOLOGICAL: Placebo|BIOLOGICAL: TNM002 Dosage 3 (100 μg/kg)|BIOLOGICAL: Placebo|BIOLOGICAL: TNM002 Dosage 4 (250 μg/kg)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Research Study to Compare Two Types of Insulin, a New Insulin, Insulin Icodec and an Available Insulin, Insulin Degludec, in People With Type 2 Diabetes Who Have Not Used Insulin Before (ONWARDS 3)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin icodec|DRUG: Placebo insulin icodec|DRUG: Insulin degludec|DRUG: Placebo insulin degludec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characterization of Fecal Microbiome Changes After Administration of PRIM-DJ2727 in Parkinson's Disease Patients
Status: WITHDRAWN
Conditions: Parkinson's Disease
Interventions: BIOLOGICAL: PRIM-DJ2727|DRUG: Placebo (for PRIM-DJ2727)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The iHealth Study in College Students
Status: COMPLETED
Conditions: Alcohol Abuse|Alcohol Dependence|Unhealthy Alcohol Use|Risky Alcohol Consumption Amounts|Hazardous Alcohol Use
Interventions: BEHAVIORAL: Brief Personalized Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Initial Triple Versus Initial Dual Oral Combination Therapy in Patients With Newly Diagnosed Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Macitentan|DRUG: Tadalafil|DRUG: Selexipag
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intervention to Reduce Misused Inhaler and Insufficient Peak Inspiratory Flow in Hospitalized COPD Patients
Status: COMPLETED
Conditions: COPD
Interventions: OTHER: Systematic and standardised assessment of inhalers and implementation of a prescribing guide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy & Safety of Seroquel Plus Mood Stabilizer in the Maintenance of Bipolar I Disorder
Status: COMPLETED
Conditions: Bipolar I Disorder
Interventions: DRUG: quetiapine fumarate|DRUG: lithium|DRUG: divalproex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Time and Resources for Hylenex-facilitated SC Rehydration Versus ORT for Dehydrated Children in the Emergency Department (ED)
Status: WITHDRAWN
Conditions: Dehydration
Interventions: OTHER: Oral rehydration fluid|DRUG: Isotonic hydration fluid and recombinant human hyaluronidase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Minocin (Minocycline) for Injection in Healthy Adults
Status: COMPLETED
Conditions: Normal Healthy Volunteers
Interventions: DRUG: Minocin (minocycline) for Injection|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Dry Needling, Static Stretching and IASTM in People With Hamstring Muscle Shortness
Status: COMPLETED
Conditions: Hamstring Muscle Shortness and Elastographic Examination
Interventions: OTHER: Dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Prospective, Non-interventional, Multinational, Observational Study With Isatuximab in Patients With Relapsed and/or Refractory Multiple Myeloma (RRMM)
Status: RECRUITING
Conditions: Plasma Cell Myeloma
Interventions: DRUG: isatuximab SAR650984|DRUG: Pomalidomide|DRUG: Dexamethasone|DRUG: Carfilzomib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase I Study to Assess the Safety and Tolerability of Topical CRx-197 Formulations in Healthy Volunteers
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: nortriptyline HCl + loratadine|DRUG: nortriptyline HCl + loratadine|DRUG: nortriptyline HCl|DRUG: mometasone furoate|DRUG: Active ingredient free vehicle cream of CRx-197
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy of Direct Observation and Mental Visualization of Foot Movements to Treat Bilateral Lower Limb Phantom Limb Pain
Status: UNKNOWN
Conditions: Phantom Limb Pain
Interventions: BEHAVIORAL: direct observation|BEHAVIORAL: mental visualization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimization of Treatment of Advanced Nonsmall Cell Lung Cancer Using Radiotherapy and Chemotherapy
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: RADIATION: radiation|OTHER: Chemotherapy and radiotherapy|DRUG: Chemotherapy|OTHER: Palliative radiotherapy and chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine Recommended Phase 2 Dose of Intravenous (IV) Eftozanermin Alfa in Combination With IV or Subcutaneous (SC) Bortezomib and Oral Dexamethasone Tablet and to Assess Change in Disease Symptoms in Adult Participants With Relapsed or Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Eftozanermin alfa|DRUG: Bortezomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Testing a Mobile App to Designed to Increase Physical Activity Among Pregnant and Postpartum Women
Status: COMPLETED
Conditions: Pregnancy|Postpartum
Interventions: BEHAVIORAL: mHealth Intervention Group|BEHAVIORAL: Educational Brochure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pulmonary and Inflammatory Responses Following Exposure to a Low Concentration of Ozone or Clean Air
Status: RECRUITING
Conditions: Lung Injury, Acute|Symptoms and Signs|Neutrophilia Acute
Interventions: BIOLOGICAL: 0.070 ppm ozone concentration|BIOLOGICAL: Clean air (0.0 ppm ozone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Performance Measurement and Safety Evaluation of the PYTHEAS® ODYSSEE Angular Assistance System for Intra-pedicular Screw Placement in Adult Spine Surgery
Status: COMPLETED
Conditions: Pedicle Screw|Surgical Navigation Systems
Interventions: DEVICE: Guided placement with PYTHEAS® ODYSSEE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Vitamin D Supplementation on Outcome and Disease Activity.
Status: UNKNOWN
Conditions: Rheumatoid Arthritis, Vitamin D , Disease Activity, DAS28ESR
Interventions: DRUG: Vitamin D 2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Closed-loop Control of Glucose Levels (Artificial Pancreas) for 12 Days in Adults With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: OTHER: 12-day intervention with sensor-augmented pump therapy|OTHER: 12-day intervention with single-hormone closed-loop strategy|DEVICE: Insulin pump|DEVICE: Continuous glucose monitoring system|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MINDFUL-OBOT: Effect of Mindfulness on Opioid Use and Anxiety During Primary Care Buprenorphine Treatment
Status: COMPLETED
Conditions: Opioid-use Disorder|Anxiety|Depression|Stress Related Disorder
Interventions: BEHAVIORAL: M-ROCC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Valsartan and the Combination of Valsartan and Simvastatin
Status: COMPLETED
Conditions: Hypertension|Hypercholesterolemia|Dyslipidemia
Interventions: DRUG: Valsartan and simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Oxygenation by 100% Oxygen Via High Flow Nasal Cannula in Surgical Patients
Status: COMPLETED
Conditions: Anaesthesia, General|Anesthesia, Intravenous|Ventilation
Interventions: PROCEDURE: Hyperventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pianzumab Combined With AVD Regimen in the Treatment of Newly-diagnosed Advanced Classic Hodgkin Lymphoma
Status: RECRUITING
Conditions: Classic Hodgkin Lymphoma
Interventions: DRUG: Concurrent penpulimab and AVD|DRUG: Sequential penpulimab and AVD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Refine and Assess the Readability of Patient, Carer, and Clinician Treatment Preference in Myelodysplasia Questionnaire
Status: COMPLETED
Conditions: Myelodysplastic Syndrome (MDS)
Interventions: OTHER: Carer Treatment Preference Myelodysplasia Questionnaire|OTHER: Clinician Treatment Preference Myelodysplasia Questionnaire|OTHER: Patient Treatment Preference Myelodysplasia Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exercise-Induced Rates of Fat Oxidation With and Without Ingestion of a Caffeine-Based Energy Drink
Status: RECRUITING
Conditions: Substrate Oxidation|Energy Expenditure|Reaction Time|Cognition|Exercise Performance
Interventions: DIETARY_SUPPLEMENT: Caffeine-Based Energy Drink|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Breakfast Test Products and Acute Satiety Scores
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: whole wheat bread yeast basis|OTHER: Oatmeal|OTHER: Cheerios|OTHER: whole wheat sourdough bread|OTHER: standard breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Video Feedback to Improve Parental Sensitivity in Mother-infant Dyads With Depressive Symptoms
Status: COMPLETED
Conditions: Parent-Child Relations|Depressive Symptoms
Interventions: BEHAVIORAL: Internet mentalization-based video feedback intervention to improve parental sensitivity in mother-infant dyads with maternal depressive symptoms|BEHAVIORAL: Psycho-Educational Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Cilostazol in Patients With Diabetic Nephropathy
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Diabetes Complications
Interventions: DRUG: Cilostazol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thrombosomes® in Acute Thoracic Aortic Dissections
Status: COMPLETED
Conditions: Thoracic Aortic Dissection
Interventions: BIOLOGICAL: Thrombosomes®|BIOLOGICAL: Standard platelet concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyclophosphamide With or Without Celecoxib in Treating Patients With Recurrent or Persistent Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer
Interventions: DRUG: cyclophosphamide|DRUG: celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety and Efficacy of MEDI5752 in Combination With Stereotactic Radiotherapy in Patients With Metastatic Sarcoma
Status: RECRUITING
Conditions: Soft Tissue Sarcoma
Interventions: COMBINATION_PRODUCT: SBRT + MEDI5752
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TTO Swabs Versus Baby Shampoo in Patients With Seborrehic Blepharitis
Status: COMPLETED
Conditions: Seborrheic Blepharitis
Interventions: DRUG: Swabs containing tea tree oil and chamomile oil|DRUG: Baby shampoo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Carbon-14-Labelled [14C] LY3437943 in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: [¹⁴C]-LY3437943
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Monocentric Trial: Stem Cell Emergency Life Threatening Limbs Arteriopathy (SCELTA)
Status: COMPLETED
Conditions: Critical Limb Ischemia
Interventions: BIOLOGICAL: Transplantation of circulating CD14+CD34+cells|BIOLOGICAL: Transplantation of BM MNC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vertical Sleeve Gastrectomy and Lifestyle Modification for the Treatment of Non-Alcoholic Steatohepatitis
Status: RECRUITING
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: PROCEDURE: Vertical Sleeve Gastrectomy|BEHAVIORAL: Lifestyle Modification Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Aromatherapy on Cognitive Functions, Anxiety and Sleep
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Lavender aromatherapy|OTHER: Rosemary aromatherapy|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial to Evaluate the Use of Pomegranate Concentrate (POMx) for the Prevention of Experimental Rhinovirus Infection
Status: COMPLETED
Conditions: Common Cold
Interventions: DIETARY_SUPPLEMENT: Pomegranate Concentrate (POMx)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Adrecizumab in Cardiogenic Shock
Status: COMPLETED
Conditions: Cardiogenic Shock|Endothelial Dysfunction
Interventions: BIOLOGICAL: Adrecizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-finding Study of GSK2248761 in Antiretroviral Therapy-experienced Subjects With NNRTI-resistant HIV Infection
Status: TERMINATED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: GSK2248761 100 mg once daily|DRUG: GSK2248761 200 mg once daily|DRUG: Etravirine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Study of KRN23 on Osteomalacia in Adults With X-linked Hypophosphatemia (XLH)
Status: COMPLETED
Conditions: X-linked Hypophosphatemia
Interventions: BIOLOGICAL: burosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Hippotherapy on The Development of Life Satisfaction, Health Literacy and Healthism Attitude of Young Adults After Cancer Treatment
Status: NOT_YET_RECRUITING
Conditions: Cancer|Nursing|Hippotherapy|Life Satisfaction
Interventions: OTHER: Hippotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pilot Feasibility Study for HypoPals, a Mobile Health Program for Improving Hypoglycemia Management.
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 1 Diabetes|Hypoglycemia
Interventions: BEHAVIORAL: Basic Education|BEHAVIORAL: Hypoglycemia Symptom Detection Training|BEHAVIORAL: Education Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: REGN2810 Followed by Chemoimmunotherapy for Newly Metastatic Hormone-sensitive Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer Metastatic
Interventions: DRUG: REGN2810|DRUG: Degarelix|DRUG: Leuprolide Acetate|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial for Patients With Loco-Regional Esophageal Carcinoma
Status: TERMINATED
Conditions: Loco-regional Esophageal Cancer
Interventions: DRUG: Bevacizumab|DRUG: Paclitaxel|DRUG: Cisplatin|DRUG: 5-Fluorouracil|RADIATION: Radiation Therapy|PROCEDURE: Esophagectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supplementation in Adolescent Girls With Endometriosis
Status: COMPLETED
Conditions: Endometriosis
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Fish Oil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Naltrexone on Nicotine Reinforcement
Status: COMPLETED
Conditions: Tobacco Dependence
Interventions: DRUG: Naltrexone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Selective Subarachnoid Anesthesia. Comparison of Hyperbaric Bupivacaine and Hyperbaric Prilocaine
Status: COMPLETED
Conditions: Knee Arthroscopy (for Diagnostic or Therapy)|Inguinal Hernia Repair (Not Urgent)
Interventions: DRUG: Hyperbaric Prilocaine 1%|DRUG: Hyperbaric bupivacaine 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of WN and WF During Gastroscopy
Status: NOT_YET_RECRUITING
Conditions: Misadventure During Endoscopic Examination
Interventions: DEVICE: Glass Waterfall group|DEVICE: white noise group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Efficacy, Safety, and Pharmacokinetics of FNP-223 to Slow Progression of Progressive Supranuclear Palsy (PSP)
Status: RECRUITING
Conditions: Progressive Supranuclear Palsy
Interventions: DRUG: FNP-223|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the OSHO Protocol to a Standard Arm Protocol of the German AML Intergroup in Patients With AML<60a
Status: UNKNOWN
Conditions: Acute Myeloid Leukaemia
Interventions: DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of a Physical Therapy Intervention on Older Adults With Hyperkyphosis or Forward Head Posture
Status: COMPLETED
Conditions: Pneumonia|COPD|Hyperkyphosis|Postural, Thoracic Kyphosis
Interventions: OTHER: Manual therapy and exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-hyperglycemic Effect of Short-term Arginyl-fructose Supplementation in Subjects With Pre-diabetes and Newly Diagnosed Type 2 Diabetes: Randomized, Double-blinded, Placebo-controlled Trial.
Status: COMPLETED
Conditions: Pre-diabetes
Interventions: DIETARY_SUPPLEMENT: Arginyl-fructose|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of tDCS in Elderly With Pain Due to Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Chronic Pain
Interventions: DEVICE: Active Transcranial Direct Current Stimulation (tDCS)|DEVICE: Sham Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Protamine for Heparin Reversal After Catheter Ablation of Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation|Catheter Ablation
Interventions: DRUG: Protamine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bacteraemia Secondary to Tooth Extraction: Chlorhexidine Prophylaxis Protocols
Status: COMPLETED
Conditions: Bacteremia|Tooth Extraction Status Nos
Interventions: DRUG: 0.2% Chlorhexidine|DRUG: 1% Chlorhexidine|DRUG: 1% Chlorhexidine|PROCEDURE: Blood extraction|DRUG: Lidocaine plus adrenaline|PROCEDURE: Tooth extraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Effects of Proprioceptive Training and Routine Physical Therapy on Diabetic Peripheral Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathies
Interventions: OTHER: Conventional Physical Therapy|OTHER: Conventional Physical Therapy with Proprioceptive Training Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: FAMily Oriented Support (FAMOS): Psychosocial Intervention for Childhood Cancer Survivors and Their Families
Status: COMPLETED
Conditions: Childhood Cancer
Interventions: BEHAVIORAL: FAMOS: psychosocial family intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Anaesthesia on ER Stress in Cancer Patients
Status: COMPLETED
Conditions: Endoplasmic Reticulum Stress
Interventions: DRUG: Propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation de O-(2-[18F]-Fluoroethyl)-L-Tyrosine, a New Tracer PET, in the Diagnosis of Low Grade Glioma
Status: COMPLETED
Conditions: Low Grade Glioma
Interventions: DRUG: O-(2[18F]FLUOROETHYL)-L-TYROSINE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neoadjuvant Immunotherapy (PD-1 / PD-L1) Combined With Chemotherapy for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma: a Single Center, Prospective, Open, One Arm Exploratory Clinical Study
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma|Neoadjuvant Therapies
Interventions: PROCEDURE: Neoadjuvant Immunotherapy (PD-1 / PD-L1) Combined With Chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Objective Evaluation of the Number of Use Hour of Oxygen Therapy in Patients Receiving Supplemental Oxygen
Status: UNKNOWN
Conditions: Chronic Respiratory Failure With Hypoxia|Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: Presentation of the adherence record
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer
Status: RECRUITING
Conditions: Endometrial Cancer
Interventions: DRUG: Navtemadlin|DRUG: Navtemadlin Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Interferential Current (IFC) Therapy After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteo Arthritis Knee
Interventions: DEVICE: Interferential Current Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of High-Dose Pulse Administration DN-101 (Calcitriol) in Patients With Myelodysplastic Syndrome (MDS)
Status: UNKNOWN
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: DN-101 (calcitriol)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Heart Rate Variability And Heart Rate/Activity Slope After Hospitalization for Acute Exacerbations of COPD
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DEVICE: VitalPatch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Brentuximab Vedotin and Bendamustine for the Treatment of Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma (ALCL)
Status: COMPLETED
Conditions: Hodgkin Lymphoma|Anaplastic Large Cell Lymphoma
Interventions: DRUG: Brentuximab Vedotin|DRUG: Bendamustine|DRUG: Neulasta
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Posterior IVS Versus Sacrospinous Suspension in Vaginal Vault Prolapse Repair
Status: COMPLETED
Conditions: Vaginal Prolapse
Interventions: DEVICE: IVS|PROCEDURE: Sacrospinofixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Use of Narrative Voice and Introduction Content to Improve Interactive Voice Response Surveys in Bangladesh and Uganda
Status: COMPLETED
Conditions: Surveys and Questionnaires|Noncommunicable Diseases
Interventions: OTHER: Female Voice|OTHER: Motivational Introduction|OTHER: Male Voice|OTHER: Informational Introduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Cervical Mobilization on Balance and Spasticity in Multiple Sclerosis Individuals
Status: COMPLETED
Conditions: Multiple Sclerosis|Balance; Distorted
Interventions: OTHER: cervical mobilisation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety Study of LE-DT to Treat Locally Advanced or Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Liposome Entrapped Docetaxel (LE-DT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Stool Sample Collection Protocol for Development of Screening Test for Colorectal Cancer and Other Digestive Tract Cancers
Status: TERMINATED
Conditions: Colorectal Neoplasms|Digestive System Diseases|Colonic Diseases|Colorectal Cancer
Interventions: DEVICE: Stool Sample Collection Kit
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use of Large Field of View During Image Acquisition for Coronary Angiography
Status: COMPLETED
Conditions: Exposure to Ionizing Radiation|Occupational Exposure to Radiation|Radiation Injury
Interventions: RADIATION: Large field of view arm|RADIATION: Medium field of view
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Baricitinib, a JAK1/2 Inhibitor, in Chronic Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation
Status: COMPLETED
Conditions: Chronic Graft vs Host Disease|Chronic Graft-Versus-Host Disease
Interventions: DRUG: Baricitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Intervention of Psychobiotics in Patients With Anxiety Disorders
Status: RECRUITING
Conditions: Anxiety Disorders
Interventions: DIETARY_SUPPLEMENT: Heat-treated PS23|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Variations of Portal Flow During the Respiratory Cycle in Healthy Volunteers
Status: ACTIVE_NOT_RECRUITING
Conditions: Respiratory Amplitude|Portal Blood Flow|MRI|Echo Planar Imaging
Interventions: OTHER: peripheral ECG|OTHER: Standard MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Nivolumab, Ipilimumab, and Radiation Therapy in Treating Patients With Stage III-IVB Head and Neck Cancer
Status: COMPLETED
Conditions: Larynx|Lip, Oral Cavity and Pharynx
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: Ipilimumab|RADIATION: Simultaneous-Integrated Boost Intensity-Modulated Radiation Therapy|RADIATION: Volume Modulated Arc Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Fibre and Chromium Picolinate Efficacy in Overweight and Obese Women
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: DIETARY_SUPPLEMENT: agglomerated glucomannan, oligofructose and chromium mixture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of SHR0302 in Patients With Non-Radiographic Axial Spondyloarthritis
Status: RECRUITING
Conditions: Non-radiographic Axial Spondyloarthritis
Interventions: DRUG: SHR0302|DRUG: SHR0302 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT