pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Scalable Interventions to Increase PrEP Adherence: Value Affirmation and Future Selves
Status: TERMINATED
Conditions: HIV Prevention
Interventions: BEHAVIORAL: Value Affirmation and Future Selves Combination|BEHAVIORAL: Control writing exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Determine the Effects of C-administration of AZD7325 and an Oral Contraceptive in Healthy Female Subjects
Status: SUSPENDED
Conditions: Pharmacokinetics
Interventions: DRUG: monophasic oral contraceptive|DRUG: AZD7325
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Treatment of Peri-implant Mucositis by Means of Implant Decontamination and Modification of the Implant Supported-prosthesis
Status: UNKNOWN
Conditions: Peri-implant Mucositis
Interventions: PROCEDURE: Modification of the implant supported prostheses in order to facilitate oral hygiene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GnRH Agonist Administration in the Luteal Phase of ICSI-ET Cycles
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: triptorelin acetate|DRUG: Na Cl %0.9
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of AAV-GAD Gene Transfer Into the Subthalamic Nucleus for Parkinson's Disease
Status: TERMINATED
Conditions: Parkinson's Disease
Interventions: GENETIC: Bilateral surgical infusion of AAV-GAD into the subthalamic nucleus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety, Pharmacokinetics and Antitumor Activities of BGB-A317 in Participants With Advanced Tumors
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: BIOLOGICAL: BGB-A317|BIOLOGICAL: BGB-A317
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Precut-EMR for Resecting of Colonic Polyp
Status: WITHDRAWN
Conditions: Colonic Polyps
Interventions: PROCEDURE: Precut EMR|PROCEDURE: Conventional MER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sarilumab and Adalimumab Monotherapy in Patients With Rheumatoid Arthritis (SARIL-RA-MONARCH)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Sarilumab|DRUG: Adalimumab|DRUG: Placebo (for sarilumab)|DRUG: Placebo (for adalimumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Micro Sclerostomy First in Man Safety and Preliminary Performance Study
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma|Pigmentary Glaucoma|Pseudoexfoliative Glaucoma
Interventions: PROCEDURE: Minimally Invasive Micro Sclerostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia
Status: RECRUITING
Conditions: Keratoconus|Pellucid Marginal Corneal Degeneration|Corneal Ectasia
Interventions: COMBINATION_PRODUCT: PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin and Raltitrexed Treatment of Colorectal Cancer With Liver Metastases
Status: UNKNOWN
Conditions: Colon Cancer Liver Metastasis
Interventions: DRUG: oxaliplatin and raltitrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Incidence of Postoperative Pain After Using Different Types of Sealers
Status: RECRUITING
Conditions: Post Operative Pain|Root Canal Sealers|Sillicon Based Sealers|Resin Based Sealers
Interventions: PROCEDURE: Primary local anesthesia|PROCEDURE: Supplemental local anesthesia|PROCEDURE: Removal Of Caries and Access Cavity|PROCEDURE: Rubber dam isolation of tooth|PROCEDURE: Bleeding control|PROCEDURE: Canal negotiation|PROCEDURE: Coronal flaring|PROCEDURE: Working Length Determination (W.L)|PROCEDURE: Glide path|PROCEDURE: Irrigation|PROCEDURE: Cleaning and shaping using rotary system|PROCEDURE: Second w.l determination|PROCEDURE: Apical gauging|PROCEDURE: Activation of the irrigant|PROCEDURE: Master cone check|DRUG: application of resin based sealer inside the canal in the resin based sealer group|DIAGNOSTIC_TEST: application of the sillicon based sealer inside the canal in the sillicon based group|PROCEDURE: Obturation|DIAGNOSTIC_TEST: Visual Analogue Scale (VAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Open Label Study of mRNA-3704 in Patients With Isolated Methylmalonic Acidemia
Status: WITHDRAWN
Conditions: Methylmalonic Acidemia (MMA)|Metabolism, Inborn Errors
Interventions: BIOLOGICAL: mRNA-3704
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Azacitidine in Myelodysplastic Syndrome (MDS) Associated to Systemic Auto-immune and Inflammatory Disorders
Status: COMPLETED
Conditions: MDS|Systemic Autoimmune Diseases
Interventions: DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Residual Allergenicity of Grass/Rye Pollen Allergoid Using Skin Prick Testing
Status: COMPLETED
Conditions: Type I Hypersensitivity
Interventions: BIOLOGICAL: Grass MATA MPL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn How Different Amounts of the Study Medicine Called PF-07328948 Are Tolerated and Act in the Body in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-07328948|DRUG: Placebo|DRUG: PF-07328948|DRUG: Placebo|DRUG: PF-07328948|DRUG: Placebo|DRUG: PF-07328948|DRUG: Placebo|DRUG: PF-07328948|DRUG: Placebo|DRUG: PF-07328948|DRUG: Placebo|DRUG: PF-07328948|DRUG: Placebo|DRUG: PF-07328948|DRUG: Placebo|DRUG: PF-07328948|DRUG: PF-07328948|DRUG: Placebo|DRUG: PF-07328948|DRUG: Placebo|DRUG: PF-07328948
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of Electro-acupuncture and Manual Therapy on Pain and Fucntion in Patients With Sciatica
Status: UNKNOWN
Conditions: Sciatica|Electroacupuncture|Manual Therapy
Interventions: OTHER: Electroacupuncture|OTHER: Manual therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Inflammation Factors and Insulin Resistance in Major Depressive Disorder
Status: UNKNOWN
Conditions: Major Depressive Disorder
Interventions: DRUG: Fluoxetine + Valsartan|DRUG: Fluoxetine + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coronary Microvascular Function and CT Coronary Angiography (CorCTCA)
Status: ACTIVE_NOT_RECRUITING
Conditions: Angina, Stable|Angina Pectoris, Variant|Microvascular Angina
Interventions: DIAGNOSTIC_TEST: Stratified medicine involving a diagnostic intervention|DIAGNOSTIC_TEST: Stratified medicine involving a diagnostic intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: MItochondrial Diabetes LOw Carb- Diet Study
Status: RECRUITING
Conditions: Mitochondrial Diseases|Diabetes-Deafness Syndrome Maternally Transmitted
Interventions: OTHER: LCHF diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Proof of Concept Study of Binocular Videogames Versus Patching for Amblyopia
Status: TERMINATED
Conditions: Amblyopia
Interventions: DEVICE: Binocular video games|DEVICE: Patching of the sound eye
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Single Versus Double Ritonavir-boosted Protease Inhibitor (PI)-Based Antiretroviral Therapy (ART) Regimens
Status: COMPLETED
Conditions: HIV Infection|HIV Infections
Interventions: DRUG: ritonavir-boosted PI-based second line treatments|DRUG: two PIs boosted by low dose ritonavir or one PI plus full dose ritonavir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Molecular Mechanisms of Resistance and Sensitivity to Palbociclib Re-challenge in ER+ mBC
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Palbociclib|DRUG: Endocrine therapy (non IMP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brodalumab (AMG 827) in Adults With Moderate to Severe Crohn's Disease
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: Brodalumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DM1, Effects of Carbo-Counting on Glycemic Control
Status: UNKNOWN
Conditions: Type 1 Diabetes Mellitus
Interventions: BEHAVIORAL: carbohydrate counting|BEHAVIORAL: insulin therapy according to standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of a Fasting Mimicking Diet on Ulcerative Colitis
Status: RECRUITING
Conditions: Inflammatory Bowel Disease|Diet Modification|Ulcerative Colitis
Interventions: OTHER: Fasting Mimicking Diet|OTHER: Regular Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parvovirus B19 Infection in Hereditary Hemolytic Anemias Patients
Status: UNKNOWN
Conditions: Parvovirus B19 Infection
Interventions: OTHER: Supportive treatment with or without red cell transfusion/intravenous immune globulin (IVIG)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Developing Mental Health Supports for Autistic Students
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Depression, Anxiety
Interventions: BEHAVIORAL: Emotional Support Plan - Clinician Guided (ESP-C)|BEHAVIORAL: Emotional Support Plan - Self Guided (ESP-S)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of RAS on Balance and Gait After Stroke
Status: COMPLETED
Conditions: Stroke|Gait, Hemiplegic|Gait Disorders, Neurologic
Interventions: OTHER: Rhythmic auditory stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early FDG PET/CT Imaging as a Measure of Response in Patients With Non-Hodgkin Lymphoma on Lenalidomide
Status: TERMINATED
Conditions: Non-Hodgkin Lymphoma
Interventions: DIAGNOSTIC_TEST: 2-Deoxy-2-[18F]fluoro-D-glucose (FDG)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety Study of Allogeneic Mesenchymal Precursor Cell Infusion in Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: OTHER: Placebo|BIOLOGICAL: Mesenchymal Precursor Cells (MPC) 12.5 M|BIOLOGICAL: Mesenchymal Precursor Cells (MPC) 25 M
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemoradiotherapy Plus Immunotherapy Followed by Surgery for Esophageal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophagus Cancer|Neoadjuvant Therapy
Interventions: DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Use of Glidescope With Fiber Optic Broncscopy Versus Fiber Optic Alone in Difficult Intubation
Status: COMPLETED
Conditions: Anesthesia
Interventions: DEVICE: comined use of gliddescope and fiberoptic broncscopy|DEVICE: fiberoptic bronscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of the GOLO for Life System Diet With and Without GOLO Release Supplement on Glycemic Control and Insulin Resistance
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DIETARY_SUPPLEMENT: RELEASE|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Aerosolized Liposomal 9-Nitro-20 (S)- Camptothecin (L9NC)
Status: COMPLETED
Conditions: Corpus Uteri|Endometrial Cancer
Interventions: DRUG: 9-NC in aerosol reservoir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crocin Supplementation in CSCR
Status: UNKNOWN
Conditions: Chorioretinopathy, Central Serous
Interventions: DRUG: Crocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Chili Pepper on Inflammation and Glycemic Control in Southern New Mexico
Status: NOT_YET_RECRUITING
Conditions: Prediabetes
Interventions: DIETARY_SUPPLEMENT: Red chili peppers|DIETARY_SUPPLEMENT: Green Chili Pepper|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effect of Lidocaine Infusion Applied at Different Doses During Lumbar Spinal Surgery on Hemodynamics and Postoperative Pain
Status: RECRUITING
Conditions: Post Operative Pain|Hemodynamic Instability|Opioid Use
Interventions: DRUG: Lidocaine IV|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Effectiveness of Therapy Via Telemedicine Following Cochlear Implants
Status: COMPLETED
Conditions: Congenital Sensorineural Deafness
Interventions: BEHAVIORAL: Telemedicine|BEHAVIORAL: In-person ART
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Albumin Infusion Effects in Mortality in Patients With Cirrhosis and Hepatic Encephalopathy
Status: UNKNOWN
Conditions: Hepatic Encephalopathy|Cirrhosis
Interventions: DRUG: Human albumin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mental Imagery Therapy for Autism (MITA) - an Early Intervention Computerized Language Training Program for Children With ASD
Status: COMPLETED
Conditions: Autistic Disorder|Autism|ASD
Interventions: OTHER: MITA Prefrontal Synthesis exercises - each activity adapts to deliver the exercise that is at the exact level of difficulty appropriate for a child at any given point in time
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sorafenib for Prophylaxis of Leukemia Relapse in Allo-HSCT Recipients With FLT3-ITD Positive AML
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Hematopoietic Stem Cell Transplantation
Interventions: DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wavefront Guided Scleral Lenses for Keratoconus and Irregular Astigmatism
Status: ACTIVE_NOT_RECRUITING
Conditions: Keratoconus|Irregular Astigmatism|Corneal Ectasia|Aberration, Corneal Wavefront|Wavefront Aberration, Corneal|Pellucid Marginal Corneal Degeneration|Keratoglobus
Interventions: DEVICE: Wavefront Guided Scleral Lenses|DEVICE: Traditional Scleral Lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trials to Assess the Efficacy and Safety of HLIM
Status: UNKNOWN
Conditions: Acute Upper Respiratory Tract Infection|Acute Bronchitis
Interventions: DRUG: Test|DRUG: Active Comparator Control 1|DRUG: Active Comparator Control 2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-blind, Flexible Dose, Multicenter Study to Evaluate the Effectiveness and Safety of Galantamine IR in Mild to Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Galantamine HBr
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Aortic Valve DECalcification (AVADEC) Trial
Status: COMPLETED
Conditions: Aortic Valve Stenosis|Multidetector Computed Tomography|Vitamin K 2|Randomised Clinical Trial
Interventions: DIETARY_SUPPLEMENT: Menaquinone-7 720 µg/day including the recommended daily dose of vitamin D (25 µg/day).|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial Comparing HLX10 With Placebo Combined With Chemotherapy (Cisplatin + 5-fu) in the First-line Treatment of Locally Advanced/Metastatic Esophageal Squamous Cell Carcinoma (ESCC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: HLX10 100 mg in 10 ml Injection|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enabling Family Physicians to Reduce Vaccine Hesitancy and Increase Covid-19 Vaccine Uptake
Status: TERMINATED
Conditions: Covid19|COVID-19 Vaccine
Interventions: BEHAVIORAL: Tailored COVID-19 vaccine messages|OTHER: Other health messages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study Investigating Rifampicin and Dolutegravir in Combination in Healthy Volunteers
Status: UNKNOWN
Conditions: HIV-1-infection|Tuberculosis
Interventions: DRUG: Dolutegravir|DRUG: Rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Cardiac Effects of ALXN2050 in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ALXN2050|DRUG: ALXN2050-matching Placebo|DRUG: Moxifloxacin|DRUG: Moxifloxacin-matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Serum Concentration of CEFOxitin Used for Antibiotic Prophylaxis in Obese Patients Undergoing BARiatric Surgery
Status: COMPLETED
Conditions: Obese|Antibiotic Prophylaxis|Bariatric Surgery Candidate
Interventions: DRUG: Serum dosage of antibiotic prophylaxis CEFOXITIN
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Feasibility of an E-Health System (ZEMY) Designed to Manage Symptoms in Participants With Breast Cancer Under Anti-Cancer Treatment
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DEVICE: ZEMY software|DRUG: Investigator's choice of anti-cancer treatment (except immunotherapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gefitinib and Capecitabine in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: capecitabine|DRUG: gefitinib|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of an Epidural Ropivacaine-Neostigmine Injection for Perineal Analgesia at the End of Labor.
Status: UNKNOWN
Conditions: Pregnancy|Vaginal Delivery
Interventions: DRUG: neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of DuoTrav APS in Patients With Open-Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Travoprost/Timolol Maleate Fixed Combination solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate PK, Safety, Tolerability of Cefepime-enmetazobactam in Pediatric Participants With cUTI
Status: RECRUITING
Conditions: Complicated Urinary Tract Infection
Interventions: DRUG: cefepime and enmetazobactam combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Echocardiographically Guided Ventriculo-Ventricular Optimization Yield a Sustained Improvement in Echocardiographic Parameters in Cardiac Resynchronization Therapy Patients? (DEVISE CRT)
Status: COMPLETED
Conditions: Cardiomyopathy|Heart Failure
Interventions: OTHER: "Sequential Arm" (Promote , model # 2207-36 or Atlas HF , model # V-343)|OTHER: "Simultaneous Arm" (Promote , model # 2207-36 or Atlas HF , model # V-343)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of the Efficacy and Safety of Two Homologous Active Principles for Local Dental Anesthesia
Status: COMPLETED
Conditions: Drug Effect|Tooth Extraction
Interventions: DRUG: Articaine / EPINEPHrine Cartridge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The DIOXXACT Trial(Diurnal IOP and OBF Xalatan vs Xalatan And Cosopt Trial)
Status: COMPLETED
Conditions: Eye Disease
Interventions: DRUG: Dorzolamide 20 mg and Timolol 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pyrotinib or Trastuzumab Plus Nab-paclitaxel as Neoadjuvant Therapy in HER2-positive Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Pyrotinib|DRUG: nab-Paclitaxel|DRUG: Trastuzumab|DRUG: EC chemotherapy|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correlation of Physical Exam Versus Non-invasive Assessment Versus Invasive Assessment of Central Venous Pressure
Status: COMPLETED
Conditions: Central Venous Pressure
Interventions: DEVICE: Mespere Venus System|PROCEDURE: Right heart catheterization (RHC)|PROCEDURE: Physical examination of jugular vein
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetic Study of Spironolactone 25 mg, 50 mg and 100 mg Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Spironolactone|DRUG: Spironolactone|DRUG: Spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Radiofrequency Intervention in Post COVID-19 Patients
Status: COMPLETED
Conditions: Covid19|Neurological Injury|Musculoskeletal Injury|Respiratory Injury
Interventions: DEVICE: Radiofrequency therapy with manual therapy|DEVICE: Placebo without radiofrequency.|OTHER: Manual therapy.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Automated Quantification of Radiologic Pulmonary Alteration During Acute Respiratory Failure: Application to the COVID-19 Pandemic
Status: RECRUITING
Conditions: SARS-CoV-2 Infections|Respiratory Failure With Hypoxia
Interventions: RADIATION: Thoracic CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Improving Care for Rural Patients With Solid Tumors
Status: RECRUITING
Conditions: Lung Cancer|Head and Neck Cancer|Thyroid Cancer|Cervical Cancer|Breast Cancer|Bladder Cancer|Colon Cancer|Rectum Cancer
Interventions: BEHAVIORAL: CARES Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Moxifloxacin_QT Study in Chinese Healthy Volunteer
Status: UNKNOWN
Conditions: QT Interval Prolongation
Interventions: DRUG: moxifloxacin|DRUG: moxifloxacin-placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Noninterventional Follow-Up Study of Children Aged 23 to 25 Months, Born to Mothers Who Received Hydroxyprogesterone Caproate Injection, 250 mg/mL, or Vehicle for Prevention of Preterm Birth
Status: COMPLETED
Conditions: Children Whose Mothers Received 17P and Those Who Received Vehicle in the 17P Efficacy Trial
Interventions: DRUG: ASQ-3, Bayley III, Neurologic exam
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study of Warm Acupuncture in Treatment of Cold-sensitive Fibromyalgia Syndrome
Status: RECRUITING
Conditions: Fibromyalgia
Interventions: DEVICE: warm acupunctrue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Roflumilast as add-on Therapy in Early Cases of ARDS
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Adult
Interventions: DRUG: Roflumilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety in Patients With Acute Coronary Syndrome Without ST-Segment Elevation
Status: COMPLETED
Conditions: Platelet Aggregation Inhibitors|NSTEACS
Interventions: DRUG: clopidogrel (SR25990C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Lactobacillus LB as Treatment for Irritable Bowel Syndrome With Predominance of Diarrhea (IBS-D)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Diarrhea
Interventions: DRUG: lactobacillus LB|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Biomarker of Exposure in Adults Who Smoke Cigarettes Switching From Cigarettes to Heated Tobacco Products
Status: ACTIVE_NOT_RECRUITING
Conditions: Tobacco Use
Interventions: OTHER: Ploom HTP Menthol HTS; MX3 (681)|OTHER: Ploom HTP Tobacco HTS; R8 (120)|OTHER: Smoking Abstinence (menthol)|OTHER: Smoking Abstinence (non-menthol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study on Safety and Immune Response of Investigational RSV OA Vaccine in Combination With Herpes Zoster Vaccine in Healthy Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Respiratory Syncytial Viruses|Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: RSVPreF3 OA investigational vaccine|BIOLOGICAL: HZ/su vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Brief Digital Screening Tool to Address Tobacco and E-cigarette Use in Pediatric Medical Care
Status: COMPLETED
Conditions: Tobacco Use|Tobacco Cessation|Second Hand Tobacco Smoke|Smoking, Tobacco|Vaping
Interventions: BEHAVIORAL: CEASE and CEASE-A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Evaluation of Blood Volume and Perceived Pain During Fingerstick Monitoring of Blood Glucose
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DEVICE: BD/33G|DEVICE: OTM / 33G|DEVICE: OTU/28G|DEVICE: ACC/28G|DEVICE: OTM/28G
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Type 2 Diabetes Mellitus With Obesity and Dyslipidemia Treated by Chinese Herbal Medicine
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus in Obese|Dyslipidemia Associated With Type II Diabetes Mellitus
Interventions: DRUG: Chinese herb medicine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy Study of Free Flap Monitoring Using Capillary Lactate and Glucose Measurements
Status: COMPLETED
Conditions: Postoperative Complications
Interventions: DEVICE: Lactate-meter: LactatePro (ARKRAY Inc)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Pudendal Block Versus Penian Block For Circumcision In Children
Status: UNKNOWN
Conditions: Regional Anesthesia|Postoperative Pain|Circumcision
Interventions: PROCEDURE: circumcision|DRUG: Lidocaine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effect of High-Definition Transcranial Direct Current Stimulation (HD-tDCS) on Attentional Control: an fMRI Study on Healthy Participants
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DEVICE: Active High-Definition Transcranial Direct Current Stimulation (HD-tDCS)|DEVICE: Sham High-Definition Transcranial Direct Current Stimulation (HD-tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Clinical Trial of LBL-034 in Patients With Relapsed Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Relapsed/Refractory Multiple Myeloma
Interventions: DRUG: LBL-034 for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Inhaled PT003 on Complexity and Variability of Tidal Breathing and Oscillatory Mechanics in Stable COPD Patient
Status: UNKNOWN
Conditions: Copd
Interventions: DRUG: Formoterol-glycopyrronium co suspension (PT003)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With Cancer
Status: RECRUITING
Conditions: Brain and Central Nervous System Tumors|Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Lymphoproliferative Disorder|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DEVICE: 3'-deoxy-3'-[18F]fluorothymidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparing Diagnostic Accuracy for Liver Tumours Between the Combination of CEUS and CEMRI Versus CECT and CEMRI
Status: COMPLETED
Conditions: Hepatocellular Carcinoma (HCC)
Interventions: DIAGNOSTIC_TEST: Sonazoid- CEUS, CEMRI, CECT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Rosiglitazone (Extended Release Tablets) As Monotherapy In Subjects With Mild To Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Rosiglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Versus Autologous Serum Eye Drops
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: OTHER: Autologous serum eye drops|OTHER: Allogeneic serum eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D and Staphylococcus Aureus in the Diabetes Study
Status: COMPLETED
Conditions: Infection
Interventions: DRUG: cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing a Peer-led Trauma-focused Intervention for Significant Others of Those With BPD
Status: NOT_YET_RECRUITING
Conditions: Posttraumatic Stress Disorder|Family Members|Spouses
Interventions: BEHAVIORAL: Trauma Recovery Program (official title TBD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study Between Levocetirizine Oral Disintegrating Tablet (ODT) and Levocetirizine Immediate Release Tablet (IRT)
Status: COMPLETED
Conditions: Rhinitis
Interventions: DRUG: Levocetirizine IRT 5 mg|DRUG: Levocetirizine ODT 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Anti-tumour Effects and Safety of Prolarix™ in Hepatocellular Carcinoma
Status: TERMINATED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Prolarix (tretazicar co-administered with caricotamide)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebral Palsy: Short-burst Interval Training
Status: COMPLETED
Conditions: Cerebral Palsy Spastic Diplegia
Interventions: BEHAVIORAL: Short Burst Interval Locomotor Treadmill Training (SBLTT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Prostate and pelvIs Versus prOsTate Alone Treatment for Locally Advanced Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: RADIATION: Prostate alone IMRT|RADIATION: Prostate and pelvis IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketofol Versus Dexmedetomidine for Prevention of Emergence Delirium in Pediatric Patients Undergoing Squint Surgeries
Status: RECRUITING
Conditions: Emergence Delirium
Interventions: DRUG: Ketamine|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Combinations of AL-335, Odalasvir (ODV) and Simeprevir (SMV) in the Treatment of Chronic Hepatitis C Infection
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: AL-335|DRUG: Odalasvir|DRUG: Simeprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Intravitreal Aflibercept Injection for Subacute Central Serous Chorioretinopathy
Status: COMPLETED
Conditions: Central Serous Chorioretinopathy
Interventions: DRUG: Intravitreal Aflibercept injection|DRUG: Sham injection|PROCEDURE: Half-fluence photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindful Mental Training for Surgeons to Enhance Resilience and Performance Under Stress
Status: COMPLETED
Conditions: Burnout Syndrome|Surgery|Stress
Interventions: BEHAVIORAL: Mindfulness Based Stress Reduction - modified|BEHAVIORAL: Active listening and reading
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase I/II Multiple Center Trial of 4SCAR19 Cells in the Treatment of Relapsed and Refractory B Cell Malignancies
Status: UNKNOWN
Conditions: B-cell Malignancies
Interventions: GENETIC: Therapeutic 4SCAR19 cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correcting GUT microbioTa by Combined Supplementation of fibERs and bIotiN to Improve Microbiome and Optimize Bariatric Surgery Outcomes
Status: RECRUITING
Conditions: Severe Obesity|Metabolic Syndrome
Interventions: OTHER: Standard of care|DIETARY_SUPPLEMENT: Biotin supplement|DIETARY_SUPPLEMENT: Fiber supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Injectable Naltrexone and Oral Bupropion Among Cigarette Smokers With Schizophrenia
Status: RECRUITING
Conditions: Smoking Cessation
Interventions: DRUG: Naltrexone (Vivitrol)|DRUG: Bupropion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Stroke Related Edema Treatments
Status: WITHDRAWN
Conditions: Acute Cerebrovascular Accident|Cerebral Edema
Interventions: DRUG: Conivaptan|DRUG: Hypertonic saline|DRUG: Mannitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regimen Switch to Dolutegravir/Lamivudine Fixed Dose Combination From Current Antiretroviral Regimen in HIV-1 Infected and Virologically Suppressed Adults (SALSA)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: DTG/3TC FDC|DRUG: CAR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simvastatin as a Neuroprotective Treatment for Moderate Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Simvastatin|DRUG: Matched Placebo (for Simvastatin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PT027 Compared to PT007 in Patients With Asthma With Mannitol-induced Acute Airway Obstruction
Status: RECRUITING
Conditions: Asthma
Interventions: COMBINATION_PRODUCT: PT027|COMBINATION_PRODUCT: PT007
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Voice Outcome of Glottoplasty, Cricothyroid Approximation, Thyroplasty, and Chondrolaryngoplasty
Status: RECRUITING
Conditions: Surgery|Larynx|Transgenderism|Gender Dysphoria
Interventions: PROCEDURE: Phonosurgery|PROCEDURE: Mastectomy/breast augmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination Chemotherapy Following GM-CSF in Treating Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: sargramostim|DRUG: cyclophosphamide|DRUG: prednisone|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of LEO 90100 Foam in Japanese Subjects With Psoriasis Vulgaris
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: LEO 90100 foam|DRUG: Dovobet® ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Lorlatinib in Subjects With ROS1-Positive Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced or Metastatic ROS1-Positive Non-Small Cell Lung Cancer
Interventions: DRUG: Lorlatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% vs. Bromfenac 0.09% in Cataract Patients: Trough Drug Effects
Status: COMPLETED
Conditions: Cataract
Interventions: DRUG: Acular, Xibrom
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mega-CHOEP: Conventional Chemo Vs HD Chemo Followed by Auto SCT in Younger Pts With Aggressive Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma (NHL)
Interventions: DRUG: R-CHOEP 14 with 12x Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Effectiveness and Costs of Bevacizumab to Ranibizumab in Patients With Diabetic Macular Edema (BRDME)
Status: UNKNOWN
Conditions: Diabetic Macular Edema
Interventions: DRUG: Ranibizumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The PulsePoint Randomized Controlled Trial
Status: WITHDRAWN
Conditions: Out-of-hospital Cardiac Arrest
Interventions: OTHER: PulsePoint notification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of ARRY-502 in Patients With Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: ARRY-502, CRTh2 antagonist; oral|DRUG: Placebo; oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Exmining the Effect of Multiple Doses of Bitopertin on the Single Dose Pharmacokinetics of Midazolam in Healthy Volunteers.
Status: WITHDRAWN
Conditions: Healthy Volunteer
Interventions: DRUG: Midazolam|DRUG: bitopertin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resilience and Exercise in Advanced Cancer Treatment
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma|Gastric Adenocarcinoma|Adenocarcinoma of the Gastroesophageal Junction
Interventions: BEHAVIORAL: Band Together|OTHER: Exercise Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Interleukin-2 in Treating Patients With Metastatic Kidney Cancer
Status: COMPLETED
Conditions: Recurrent Renal Cell Carcinoma|Stage IV Renal Cell Cancer
Interventions: BIOLOGICAL: Aldesleukin|BIOLOGICAL: Bevacizumab|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Glucose Monitoring and Cerebral Oxygenation in Preterm Infants
Status: RECRUITING
Conditions: Infant Development|Hypoglycemia Neonatal|Neurodevelopmental Abnormality
Interventions: DEVICE: Unblinded - CGM (Medtronic Guardian)|DEVICE: Blinded - CGM (Medtronic Guardian)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Chloroquine for Reducing Immune Activation in HIV- Infected Individuals
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Chloroquine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sevoflurane Versus Propofol on Optic Nerve Sheath Diameter During Anesthesia in Steep Trendelenburg Position
Status: UNKNOWN
Conditions: Percentage of Change in ONSD During Anesthesia With Sevoflurane Versus Propofol in Two Groups of Patients
Interventions: DRUG: Sevoflurane Inhalant Product|DRUG: Propofol 10 MG/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Combined Effects of Aerobic Exercise and Cognitive Training on Cognition After Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: BEHAVIORAL: Aerobic training|BEHAVIORAL: Cognitive training|BEHAVIORAL: Range of motion exercise|BEHAVIORAL: Unstructured mental activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT