pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy Study of Granulocyte-macrophage Colony Stimulating Factor (GM-CSF) for Use in Human IVF
Status: COMPLETED
Conditions: Infertility
Interventions: DEVICE: Test culture|DEVICE: Control culture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Musical Intervention on the Anxiety of Patients With a Diagnosis of Acute Coronary Syndrome in a Pre-Hospital Emergency Situation: MuSCA Randomized Controlled Trial
Status: RECRUITING
Conditions: Acute Coronary Syndrome
Interventions: PROCEDURE: Music care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Monoclonal Antibody Therapy in Treating Patients With Relapsed or Refractory Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: RADIATION: indium In 111 monoclonal antibody MN-14|RADIATION: yttrium Y 90 monoclonal antibody MN-14
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Studying Genes for Barrett's Esophagus in Brothers and Sisters
Status: UNKNOWN
Conditions: Esophageal Cancer|Precancerous Condition
Interventions: GENETIC: comparative genomic hybridization|GENETIC: genetic linkage analysis|OTHER: laboratory biomarker analysis|OTHER: questionnaire administration|PROCEDURE: study of high risk factors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chemotherapy With or Without Immunotherapy in Treating Patients With Stage III or Stage IV Melanoma
Status: COMPLETED
Conditions: Stage IV Melanoma|Stage III Melanoma|Recurrent Melanoma
Interventions: DRUG: allovectin-7|DRUG: allovectin-7/dacarbazine|DRUG: dacarbazine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comtess® Versus Cabaseril® as Add-on to Levodopa in the Treatment of Parkinsonian Patients Suffering From Wearing- Off.
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Comtess®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ustekinumab for the Treatment of Giant Cell Arteritis
Status: TERMINATED
Conditions: Giant Cell Arteritis|Temporal Arteritis|Horton's Disease
Interventions: DRUG: Ustekinumab|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Correcting Hyperglycemia in Patients With Diabetes Having Out-patient Surgery
Status: WITHDRAWN
Conditions: Type 1 Diabetes|Type 2 Diabetes
Interventions: DRUG: Regular Insulin|DRUG: Humalog
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Perioperative Lidocaine Infusion on Neutrophil Extracellular Trapping
Status: WITHDRAWN
Conditions: Gastric Cancer
Interventions: DRUG: Lidocaine|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Efficacy of Teprenone On Chinese Patients With Chronic Non-Atrophic Erosive Gastritis
Status: COMPLETED
Conditions: Chronic Erosive Gastritis
Interventions: DRUG: Teprenone capsule and placebo of sucralfate|DRUG: Sucralfate and placebo of teprenone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Methotrexate Versus Triamcinilone Acetonide in Treatment of Recalcitrant Alopecia Areata
Status: NOT_YET_RECRUITING
Conditions: Alopecia Areata
Interventions: DRUG: Methotrexate|DRUG: Triamcinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Three Simulators for Colposcopy LEEP Training
Status: UNKNOWN
Conditions: Colposcopy
Interventions: DEVICE: Reeve's model|DEVICE: Hefler's model|DEVICE: Ida's model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: An Evaluation of Dupilumab in Patients With Moderate to Severe Uncontrolled Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Dupilumab|DRUG: placebo|DRUG: ICS/LABA therapy|DRUG: Salbutamol/albuterol|DRUG: Levosalbutamol/levalbuterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Trans Sodium Crocetinate (TSC) With Radiation and Temozolomide in Newly Diagnosed Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma|GBM|Glioma
Interventions: DRUG: Trans Sodium Crocetinate (TSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Performance and Safety of Biology-Guided Radiotherapy Using the RefleXion Medical Radiotherapy System (BIOGUIDE-X)
Status: COMPLETED
Conditions: Cancer|Tumor, Solid|Cancer, Lung|Cancer, Bone|Metastasis to Lung|Metastasis to Bone
Interventions: DEVICE: RMRS IDE Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Quantitative Analysis of PET/CT Images of Immune Related Side Effects in Metastatic Melanoma Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma|PET CT
Interventions: DIAGNOSTIC_TEST: additional PET/CT at 4 weeks, analysing using quantative analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study on the Efficacy of Speed-Feedback Therapy for Elderly People With Dementia
Status: COMPLETED
Conditions: Dementia
Interventions: DEVICE: Speed-feedback therapy system with a bicycle ergometer|DEVICE: Ergometer at conventional settings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimize Radioactive Iodine Ablation Of Remnant Thyroid in Differentiated Thyroid Cancer
Status: UNKNOWN
Conditions: Thyroid Neoplasms
Interventions: DRUG: I131|DRUG: I123
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Articaine Computer-controlled and Conventional Delivery for Anterior and Middle Superior Alveolar Nerve Block
Status: COMPLETED
Conditions: Local Anesthesia
Interventions: DEVICE: Computer controlled anesthetic delivery by Anaeject|DEVICE: Conventional anesthetic delivery by carpule syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Implications of Acutaping on Nausea and Vomiting During Pregnancy
Status: COMPLETED
Conditions: Nausea|Vomiting of Pregnancy
Interventions: OTHER: Acutaping|DRUG: Doxylamine and Pyridoxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LIver Transplantation for Non-Resectable Intrahepatic CholAngiocarcinoma (LIRICA)
Status: RECRUITING
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: PROCEDURE: Liver transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy With Iron Oxide Nanoparticles (SPION) on MR-Linac for Primary & Metastatic Hepatic Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Liver Neoplasms|Hepatic Cirrhosis|Hepatic Carcinoma|Liver Cancer|Liver Metastases|Liver Carcinoma|Hepatocellular Carcinoma|Hepatocellular Cancer|Hepatic Atrophy
Interventions: DRUG: Ferumoxytol injection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion With Instrumentation
Status: ACTIVE_NOT_RECRUITING
Conditions: Degenerative Disc Disease
Interventions: DEVICE: P-15L Bone Graft|OTHER: Local autologous bone in a TLIF with Instrumentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tiny Cargo, Big Deal! An ED-Based Study of Child Passenger Safety Behaviors
Status: ACTIVE_NOT_RECRUITING
Conditions: Accident, Traffic
Interventions: BEHAVIORAL: Tiny Cargo, Big Deal/Abróchame Bien, Cuídame Bien (TCBD/ABCB) Basic Intervention|BEHAVIORAL: Tiny Cargo, Big Deal/Abróchame Bien, Cuídame Bien (TCBD/ABCB) Enhanced Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neural and Antidepressant Effects of Propofol
Status: ACTIVE_NOT_RECRUITING
Conditions: Treatment Resistant Depression
Interventions: DRUG: Propofol|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study of Abiraterone Acetate in Patients With Severe Hepatic Impairment Compared to Patients With Normal Hepatic Function
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: Cohort 1|DRUG: Cohort 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ramucirumab (IMC-1121B) Drug Product (DP) and Best Supportive Care (BSC) Versus Placebo and BSC as 2nd-Line Treatment in Participants With Hepatocellular Carcinoma After 1st-Line Therapy With Sorafenib
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: Ramucirumab DP (IMC-1121B)|OTHER: BSC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Clinical Study of Preoperative and Postoperative Unilateral Mild Cataract Patients
Status: UNKNOWN
Conditions: Cataract Senile
Interventions: DEVICE: monofocal IOL,bifocal IOL,or trifocal IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Venous ULcer TReatment Analyzing Bio-Electrical Stimulation Therapy
Status: UNKNOWN
Conditions: Chronic Venous Leg Ulcers
Interventions: DEVICE: KFH NOVO (inactive) + SCT|DEVICE: KFH Novo (BEST) + SCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study for Women and Men With Hormone-receptor Positive Locally Advanced or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Advanced Metastatic Breast Cancer
Interventions: DRUG: ribociclib|DRUG: letrozole|DRUG: goserelin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 5-HTP and Creatine for Depression R33 Phase
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DRUG: Low Dose 5-hydroxytryptophan|DRUG: High Dose 5-hydroxytryptophan|DRUG: Low Dose Creatine Monohydrate|DRUG: High Dose Creatine Monohydrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Randomized, Controlled Study Comparing Three Tibial Component Designs in Total Knee Arthoplasty
Status: COMPLETED
Conditions: Total Knee Arthroplasty
Interventions: DEVICE: The Zimmer NexGen Legacy Knee System, modular cemented tibia|DEVICE: The Zimmer NexGen Legacy Knee System, non-modular cemented tibia.|DEVICE: The Zimmer NexGen Legacy Knee System, non-modular uncemented tibia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Reducing Arrhythmia in Dialysis by Adjusting the Rx Electrolytes/Ultrafiltration, Study A
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: OTHER: Potassium Removal Maximization|OTHER: Potassium Gradient Minimization|OTHER: Alkalosis Avoidance|OTHER: Acidosis avoidance|DIAGNOSTIC_TEST: Point of Care Testing|DEVICE: Cardiac Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ropivacaine For Post-POEM Pain Control
Status: COMPLETED
Conditions: Achalasia|Esophageal Achalasia
Interventions: DRUG: Ropivacaine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Blinding Assessment of Manual Therapy Interventions of the Back in Swiss Graduate Students
Status: COMPLETED
Conditions: Back Pain|Back Disorder|Back Pain, Low
Interventions: OTHER: Active manual therapy|OTHER: Control manual therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate Tolerability and Participants Preference Between Mirabegron and Tolterodine Extended Release (ER) in Participants With Overactive Bladder (OAB)
Status: COMPLETED
Conditions: Overactive Bladder (OAB)
Interventions: DRUG: Mirabegron|DRUG: Tolterodine ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Whole Body Vibration Training on Lumbar Proprioception and Postural Stability in Healthy Adults
Status: RECRUITING
Conditions: Proprioception, Postural Balance
Interventions: OTHER: Whole Body Vibration Training|PROCEDURE: Core Stability Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Hyper-performance - Effects of Stimulating Substances in Chess-players
Status: COMPLETED
Conditions: Cognitively Healthy Subjects Influenced by Psychoactive Drugs
Interventions: DRUG: Drugs use: methylphenidate|DRUG: Drug use: modafinil|DRUG: caffeine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase II Trial of Bicalutamide in Patients Receiving Intravesical BCG for Non-muscle Invasive Bladder Cancer
Status: RECRUITING
Conditions: Non-Muscle Invasive Bladder Cancer
Interventions: DRUG: Bicalutamide|BIOLOGICAL: Control Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Duct-to-mucosa Versus Invagination for Pancreaticojejunostomy
Status: UNKNOWN
Conditions: Pancreatic Neoplasms|Biliary Tract Neoplasms
Interventions: PROCEDURE: duct-to-mucosa|PROCEDURE: invagination|DEVICE: Internal stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Buprenorphine Physician-Pharmacist Collaboration in the Management of Patients With Opioid Use Disorder: CTN 0075
Status: COMPLETED
Conditions: Opioid Use Disorder
Interventions: DRUG: buprenorphine/naloxone|OTHER: Pharmacist-administered buprenorphine/naloxone maintenance care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Rifampicin on the Pharmacokinetics of Abiraterone in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Abiraterone acetate|DRUG: Rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Immediate Versus Delayed Initiation of Transdermal Hormonal Contraception After Therapeutic Abortion
Status: COMPLETED
Conditions: Abortion
Interventions: BEHAVIORAL: timing of initiation of transdermal patch after an abortion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Longitudinal Therapeutically Non-interventional Study of MSRV-Env Burden in Patients With Multiple Sclerosis Disease
Status: COMPLETED
Conditions: Multiple Sclerosis (MS)|Relapsing-Remitting MS|Primary Progressive MS|Secondary Progressive MS|Clinically Isolated Syndrome (CIS)
Interventions: OTHER: No study treatments administered - blood draws only
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of a Neonatologist's Standardized Guidance Intervention on Preterm Infants With Relational Withdrawal.
Status: UNKNOWN
Conditions: Social Withdrawal of Childhood or Adolescence|Preterm Infant
Interventions: BEHAVIORAL: Verbal Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SAFE at Home: A Service to Provide Social Engagement to Community-Dwelling Persons With Dementia
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer Disease|Dementia|Dementia, Vascular|Dementia, Mixed
Interventions: BEHAVIORAL: SAFE at Home
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ovarian Morphology and Theca Cell Androgen Production in Women With Polycystic Ovary Syndrome (PCOS)
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: hCG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: To Evaluate the Introduction of a Public Health Approach to Peripheral Arterial Disease (PAD) Using National Centre for Sport and Exercise Medicine Facilities.
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: OTHER: PAD tailored care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of ZN-c3 in Patients With Ovarian Cancer
Status: RECRUITING
Conditions: Solid Tumor|Epithelial Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Cancer
Interventions: DRUG: ZN-c3|DRUG: Carboplatin|DRUG: Pegylated liposomal doxorubicin|DRUG: Paclitaxel|DRUG: Gemcitabine|BIOLOGICAL: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2b Study of an Investigational Malaria Vaccination Strategy in 5-17 Month Old Infants and Children in Burkina Faso
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: ChAd63 ME-TRAP and MVA ME-TRAP|BIOLOGICAL: Rabies vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Phase 1, First-in-human Study of VX-828
Status: RECRUITING
Conditions: Cystic Fibrosis
Interventions: DRUG: VX-828|DRUG: Placebo|DRUG: Itraconazole|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-treatment With Azithromycin to Reduce Immunogenicity to to Anti-TNF Agents in Patients With Crohn's Disease
Status: RECRUITING
Conditions: Crohn's Disease Relapse|Biological Substance; Adverse Effect
Interventions: DRUG: Azithromycin Pill|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Islatravir (MK-8591) With Doravirine and Lamivudine in Participants Infected With Human Immunodeficiency Virus Type 1 (MK-8591-011)
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: Islatravir|DRUG: Placebo to Islatravir|DRUG: Doravirine|DRUG: Placebo to Doravirine|DRUG: Lamivudine|DRUG: Placebo to Lamivudine|DRUG: Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate|DRUG: Placebo to Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate|DRUG: Doravirine/Islatravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Premedication and Haemodynamics After Spinal Anesthesia
Status: COMPLETED
Conditions: Hemodynamics After Spinal Anesthesia
Interventions: DRUG: Morphine hydrochloride; Midazolam|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Program to Overcome Pelvic Pain Study
Status: COMPLETED
Conditions: Pelvic Pain|Chronic Pelvic Pain|Recurrent Pelvic Pain
Interventions: OTHER: Yoga Program|OTHER: Physical Conditioning Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Parent Engagement Package: Initial Testing of Strategies to Increase Participation in Parenting Interventions
Status: COMPLETED
Conditions: Patient Compliance
Interventions: OTHER: Promotional Brochure|OTHER: Family Testimonial Flyer|OTHER: Teacher Endorsement|OTHER: Provider Engagement Call
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Cellcept for Treatment of Juvenile Neuronal Ceroid Lipofuscinosis
Status: COMPLETED
Conditions: Juvenile Neuronal Ceroid Lipofuscinosis
Interventions: DRUG: Mycophenolate mofetil|DRUG: Liquid Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TLK286 in Treating Patients With Advanced Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: canfosfamide hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study on Functional Electrical Stimulation (FES) Cycling Following Spinal Cord Injury
Status: TERMINATED
Conditions: Spinal Cord Injury
Interventions: DEVICE: FES Cycling|DEVICE: Cycling without FES|PROCEDURE: Lumbar puncture|BEHAVIORAL: Mood assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Radiation Therapy in Treating Patients Who Are Undergoing Surgery for Locally Advanced Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: capecitabine|DRUG: carboplatin|DRUG: docetaxel|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Implantable Neuromodulation for Poststroke Hemiplegia
Status: NOT_YET_RECRUITING
Conditions: Stroke Sequelae|Deep Brain Stimulation|Vagus Nerve Stimulation|Motor Recovery|Stroke|Hemiplegia
Interventions: PROCEDURE: The DBS electrodes are implanted into MLR.|PROCEDURE: The electrodes are implanted into the patient's vagus nerve
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Multi-center Study
Status: COMPLETED
Conditions: Pancreatitis|Cholangitis|Cholecystitis
Interventions: DEVICE: Tracer Hybrid® Wire Guides, Tracer Metro® Direct™ Wire Guide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Remote Ischemic Preconditioning of Dynamic Cerebral Autoregulation in Healthy Adults
Status: COMPLETED
Conditions: Ischemic Preconditioning
Interventions: DEVICE: Remote ischemic conditioning equipment|PROCEDURE: Intravenous blood collection|PROCEDURE: dCA measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (Naltrexone/Nicotine Patch)
Status: COMPLETED
Conditions: Alcoholism|Smoking
Interventions: DRUG: naltrexone (Revia)|DRUG: nicotine replacement patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Clarithromycin on PK of Linaprazan, Linaprazan on PK of Clarithromycin and Linaprazan on PK of Midazolam
Status: COMPLETED
Conditions: Safety Issues|Pharmacokinetics|Drug Interaction|Tolerability
Interventions: DRUG: Linaprazan glurate|DRUG: Drug drug interaction (DDI) - Clarithromycin (Part I)|DRUG: Drug drug interaction (DDI) - Midazolam (Part 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Danoprevir Boosted With Low Dose Ritonavir in Combination With Pegasys and Copegus in Treatment-Naive Patients With Chronic Hepatitis C Virus Infection
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Copegus|DRUG: Danoprevir|DRUG: Danoprevir|DRUG: Danoprevir|DRUG: Pegasys|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Palbociclib in Elderly Patients With Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer Stage II|Breast Cancer Stage III
Interventions: DRUG: Palbociclib|DRUG: Docetaxel / cyclophosphamide|DRUG: doxorubicin/cyclophosphamide|DRUG: epirubicin/cyclophosphamide|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stimulate the Face to Improve Tactile Acuity on the Hand
Status: UNKNOWN
Conditions: Stroke|RSS|Face
Interventions: PROCEDURE: RSS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immunomodulatory Effect of Macrolides in Naturally Occurring Influenza Virus Infections in the Community
Status: SUSPENDED
Conditions: Influenza, Human
Interventions: DRUG: Clarithromycin 250 MG|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Effects of Metformin Therapy in Obstructive Sleep Apnea
Status: TERMINATED
Conditions: Sleep Apnea, Obstructive
Interventions: DRUG: Metformin + PAP|DRUG: Placebo oral capsule + PAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Incidental Finding of Gastrointestinal Stromal Tumors (GISTs) During Laparoscopic Sleeve Gastrectomy, How to Deal? How Much Safety Margin
Status: UNKNOWN
Conditions: Excision Margin
Interventions: PROCEDURE: Laparoscopic sleeve gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Netupitant and Palonosetron Hydrochloride Capsules in Preventing Nausea and Vomiting Induced by Radiochemotherapy in Head and Neck Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma (HNSCC)
Interventions: DRUG: Netopitam Palonosetron capsules and dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Desensitization to Reduce Oral Hypersensitivity and Improve Intake for Children With Feeding Disorders
Status: COMPLETED
Conditions: Feeding Disorder
Interventions: BEHAVIORAL: Desensitization with flipped spoon|BEHAVIORAL: flipped spoon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sucralose Effects on Glucose Metabolism and Gut Microbiota
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Sucralose|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Warmed Humidified CO2 on Peritoneum During Laparotomy
Status: COMPLETED
Conditions: Peritoneal Inflammation|Peritoneum; Injury
Interventions: DEVICE: Humidified, warmed CO2 insufflation of open peritoneum using Fisher & Paykel's HUMIGARD (Fisher & Paykel Healthcare Ltd, Auckland, New Zealand)|DEVICE: Standard heating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD)
Status: RECRUITING
Conditions: Major Depressive Disorder|Depression
Interventions: DRUG: REL-1017|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of PT001 to Placebo and Open-label Spiriva® Respimat® in Subjects With Persistant Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: GP MDI 28.8 μg|DRUG: GP MDI 14.4 μg|DRUG: GP MDI 7.2 μg|DRUG: Placebo MDI|DRUG: Spiriva Respimat 2.5 μg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OMega-3 Fatty Acid for the Immune Modulation of Colorectal Cancer
Status: WITHDRAWN
Conditions: Colon Cancer
Interventions: DRUG: AMR101 (VASCEPA, icosapent ethyl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adenosine Receptors Influence Ischemia-Reperfusion Injury
Status: SUSPENDED
Conditions: Ischemia-Reperfusion Injury
Interventions: DRUG: acetylcholine|PROCEDURE: twenty minutes of forearm ischemia|PROCEDURE: three 5-minute periods of forearm ischemia|DRUG: adenosine|DRUG: caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose:
Clinical trial: A Clinical Trial to Evaluate the Safety and Effectiveness of Resorbable Collagen Membrane - MatrixflexTM
Status: UNKNOWN
Conditions: Periodontal Diseases|Intrabony Defects|Guided Tissue Regeneration
Interventions: DEVICE: Guided Tissue Regeneration (GTR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Low vs. Very Low Dose of Prophylactic Tranexamic Acid for Bleeding Reduction During Rhinoplasty
Status: UNKNOWN
Conditions: Bleeding Reduction
Interventions: DRUG: Tranexamic Acid|DRUG: Tranexamic Acid|DRUG: Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Safety and Efficacy of Phenoptin™ in Subjects With Phenylketonuria Who Have Elevated Phenylalanine Levels
Status: COMPLETED
Conditions: Phenylketonurias
Interventions: DRUG: sapropterin dihydrochloride, 6R-BH4, tetrahydrobiopterin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Cardiac Band Ligation for the Management of Refractory GERD After Laparoscopic Sleeve Gastrectomy
Status: WITHDRAWN
Conditions: GERD|Bariatric Surgery|Laparoscopic Sleeve Gastrectomy
Interventions: PROCEDURE: Cardia Band Ligation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of PolyIC and PD-1 mAb in Subjects With Unresectable Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: PD-1 mAb|DRUG: PolyIC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer
Status: TERMINATED
Conditions: Brain and Central Nervous System Tumors|Childhood Langerhans Cell Histiocytosis|Gastrointestinal Carcinoid Tumor|Head and Neck Cancer|Intraocular Melanoma|Islet Cell Tumor|Kidney Cancer|Lung Cancer|Melanoma (Skin)|Neoplastic Syndrome|Neuroendocrine Carcinoma of the Skin|Pheochromocytoma
Interventions: RADIATION: indium In 111 pentetreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Tolerability of MBF-015 in Healthy Young Volunteers
Status: COMPLETED
Conditions: Safety and Pharmacokinetic
Interventions: DRUG: MBF-015 4 mg oral capsule|DRUG: MBF-015 16 mg oral capsule|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Research Study Comparing a New Medicine Oral Semaglutide to Placebo in People With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Oral semaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study of Finasteride 5 mg Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Finasteride 5 mg Tablet, single dose|DRUG: Proscar® 5 mg Tablet, single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Laser Assisted Procedures in Penetrating Keratoplasty
Status: COMPLETED
Conditions: Keratoconus|Corneal Dystrophies|Corneal Opacity
Interventions: PROCEDURE: Penetrating keratoplasty|DEVICE: Femtosecond laser|DEVICE: Diode laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Tolerability of Zavesca® (Miglustat) In Patients With Juvenile GM2 Gangliosidosis
Status: COMPLETED
Conditions: Gangliosidoses GM2
Interventions: DRUG: miglustat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trilaciclib (G1T28) in Patients With Previously Treated Extensive Stage SCLC Receiving Topotecan Chemotherapy
Status: TERMINATED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Trilaciclib|DRUG: Placebo|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Post Market Study To Collect Efficacy Data For The Treatment Of Wrinkles With A Radiofrequency Device
Status: COMPLETED
Conditions: Wrinkle|Benign Pigmented Lesions|Benign Vascular Lesions
Interventions: DEVICE: TempSure|DEVICE: Icon
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Naltrexone Treatment of Alcohol Abuse in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Mental Disorders|Alcohol Abuse|Alcoholism|Alcohol-related Disorders
Interventions: DRUG: Naltrexone or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coherent Sine Burst (CSE) Electroporation System Pilot Study in Patients With Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: Arga Medtech Coherent Sine-Burst Electroporation (CSE) Ablation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Recovery Through a Combined Mechanobiologic Intervention Following Meniscus Repair
Status: NOT_YET_RECRUITING
Conditions: Meniscus Tear|Meniscus; Derangement|Meniscus Lesion|Meniscus Disorder
Interventions: DRUG: Fisetin|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MRI Guided High Intensity Focused Ultrasound (HIFU) and ThermoDox for Palliation of Painful Bone Metastases
Status: WITHDRAWN
Conditions: Painful Bone Metastases|Breast Carcinoma|Non-small Cell Lung Cancer|Small Cell Lung Cancer|Adenocarcinoma
Interventions: DRUG: High Intensity Focused Ultrasound (HIFU) in combination with ThermoDox
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Treatment Duration and Stimulation Frequency on rTMS in Chronic Tinnitus
Status: COMPLETED
Conditions: Chronic Tinnitus
Interventions: OTHER: standard multisite four weeks|OTHER: high-frequency multisite four weeks|OTHER: standard multisite two weeks|OTHER: high-frequency multisite two weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Romiplostim for Chemotherapy-induced Thrombocytopenia in Adult Subjects With Lymphoma.
Status: WITHDRAWN
Conditions: Chemotherapy-induced Thrombocytopenia
Interventions: BIOLOGICAL: Romiplostim|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Kidney Injury in Cancer Patients Receiving Anti-Vascular Endothelial Growth Factor Monoclonal Antibody vs Immune Checkpoint Inhibitors
Status: COMPLETED
Conditions: AKI Incidence of Cancer Patients Receiving AntiVEGF or ICIs
Interventions: DRUG: AntiVEGF|DRUG: ICIs
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open-Label Study of Uridine Triacetate in Pediatric Patients With Hereditary Orotic Aciduria
Status: COMPLETED
Conditions: Hereditary Orotic Aciduria
Interventions: DRUG: uridine triacetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ursodeoxycholic Acid (UDCA) as a Neuroprotective Adjuvant Treatment to Rhegmatogenous Retinal Detachment Surgery
Status: NOT_YET_RECRUITING
Conditions: Retinal Detachment
Interventions: DRUG: Ursolvan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin Type A for Foot Dystonia-associated Pain in Parkinson's Disease
Status: UNKNOWN
Conditions: Dystonia Disorder|Parkinson Disease
Interventions: DRUG: Botulinum toxin type A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Zoledronic Acid, Pravastatin, and Lonafarnib for Patients With Progeria
Status: ACTIVE_NOT_RECRUITING
Conditions: Progeria
Interventions: DRUG: Lonafarnib, Zoledronic Acid, and Pravastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does the Needle-pilot Device Improve the Success of Vascular Catheterization Compared to the Classical Ultrasound-guided Technique
Status: COMPLETED
Conditions: Central Venous Catheters|Ultrasound Guidance
Interventions: DEVICE: Needle-pilotTM device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of 3% Hypertonic Saline in Acute Viral Bronchiolitis
Status: COMPLETED
Conditions: Acute Viral Bronchiolitis
Interventions: DRUG: 3% Saline|DRUG: 0.9% Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Maintaining Visual Performance Achieved With Cyclosporine Therapy
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: cyclosporine 0.05% ophthalmic emulsion|DRUG: carboxymethylcellulose-based lubricant eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation PfSPZ-CVac
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Chloroquine Phosphate|DRUG: Pyrimethamine|BIOLOGICAL: Sanaria PfSPZ Challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Hypofractionated Radiotherapy for Localized Prostate Cancer (With CyberKnife or With IMRT)
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: PROCEDURE: Hypo-fractionated Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Brain Training Through Visual Mirror Feedback, Action Observation Training and Motor Imagery on Orofacial Sensorimotor Variables in Asymptomatic Subjects: A Single-blind Randomized Controlled Trial.
Status: UNKNOWN
Conditions: Exercise|Pain
Interventions: BEHAVIORAL: Exercise plus action observation|BEHAVIORAL: Exercise plus motor imagery|BEHAVIORAL: Exercise plus visual mirror feedback|BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib Combined With Gefitinib in the Treatment of Lenvatinib-resistant Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Molecular Targeted Therapy
Interventions: DRUG: Lenvatinib and Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-range Finding Treosulfan-based Conditioning
Status: COMPLETED
Conditions: Hematological Malignancies
Interventions: DRUG: Treosulfan|DRUG: Treosulfan|DRUG: Treosulfan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Culturally Responsive Community Driven Substance Use Recovery for Black and Latinx Population
Status: RECRUITING
Conditions: Substance Use|Mental Health Issue|Opioid Use|Medication Assisted Treatment
Interventions: BEHAVIORAL: IMANI|BEHAVIORAL: Telehealth MAT|BEHAVIORAL: Traditional MAT plus Referral and Linkage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence and Impact on Quality of Life of Airway Disease in Patients With Idiopathic Pulmonary Fibrosis
Status: UNKNOWN
Conditions: Idiopathic Pulmonary Fibrosis|Airway Disease
Interventions: DIAGNOSTIC_TEST: Confirmation of Airway Disease combined with IPF
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Trial of ALE.F02 in Patients With Advanced Liver Fibrosis and/or With Mild Cirrhosis
Status: RECRUITING
Conditions: Advanced Liver Fibrosis|Liver Cirrhosis
Interventions: DRUG: ALE.F02|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of a Urethral Catheter Coated With Eluting Silver Salts (SUCCESS)
Status: TERMINATED
Conditions: Catheterization
Interventions: DEVICE: Hydrogel Silver Salts Coated Latex Urinary Catheter System|DEVICE: Bard silicone elastomer coated latex catheter system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Wearing a Powered Ankle-Foot Prosthesis on Amputee Walking
Status: COMPLETED
Conditions: Traumatic Amputation of Lower Extremity
Interventions: DEVICE: Powered ankle-foot prosthesis|OTHER: No device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Different Prophylaxis Regimens for Moderate to Severe Hemophilia A Pediatric Patients
Status: COMPLETED
Conditions: Hemophilia A
Interventions: DRUG: FVIII|DRUG: FVIII
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT