pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study to Evaluate the Efficacy and Safety of Armodafinil Treatment (150 mg/Day) as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Armodafinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With Biktarvy
Status: RECRUITING
Conditions: HIV-1-infection
Interventions: DRUG: Bictegravir|DRUG: Lenacapavir|DRUG: B/F/TAF|DRUG: Placebo to match B/F/TAF|DRUG: Placebo to match BIC/LEN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Diet and Exercise in Acute Lymphoblastic Leukemia (IDEAL Weight in ALL)
Status: COMPLETED
Conditions: B Precursor Type Acute Leukemia
Interventions: BEHAVIORAL: Dietary Intervention|BEHAVIORAL: Activity and Exercise Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vorinostat and Decitabine in Treating Patients With Relapsed, Refractory, or Poor-Prognosis Hematologic Cancer or Other Diseases
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Chronic Myelomonocytic Leukemia|Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable|Philadelphia Chromosome Negative Chronic Myelogenous Leukemia|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Relapsing Chronic Myelogenous Leukemia
Interventions: DRUG: decitabine|DRUG: vorinostat|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for Pain Control in the Emergency Department
Status: TERMINATED
Conditions: Neck Pain|Ankle Injuries|Headache Disorders, Primary
Interventions: PROCEDURE: Acupuncture plus standard ED management|PROCEDURE: Standard ED management alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Caloric Restriction Alone Versus Postoperative Caloric Restriction Following Bariatric Surgery on Glucose Metabolism in Patients With Diabetes Mellitus
Status: TERMINATED
Conditions: Obesity|Bariatric Surgery|Morbid Obesity|Diabetes Mellitus Type 2|Diet Therapy
Interventions: OTHER: Roux-en-Y Gastric Bypass|OTHER: Caloric Restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Canine-assisted Psychotherapy Motivation Alliance
Status: RECRUITING
Conditions: Motivation|Alliance, Therapeutic
Interventions: BEHAVIORAL: Standard Psychotherapy|BEHAVIORAL: Canine-assisted psychotherapy with dog actively integrated.|BEHAVIORAL: Canine-assisted psychotherapy with dog passively integrated.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between Caudal Epidural Block and Bilateral Erector Spinae Plane Block in Lumbosacral Spine Surgeries.
Status: NOT_YET_RECRUITING
Conditions: Postoperative Pain, Acute
Interventions: PROCEDURE: caudal epidural block|PROCEDURE: bilateral erector spinae plane block|PROCEDURE: general anesthesia with intravenous analgesia.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Attitudes, Beliefs, and Preferences of Older Stage I-III Breast Cancer Survivors Towards Physical Activity
Status: COMPLETED
Conditions: Cancer Survivor|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: OTHER: One-on-one interview|OTHER: Survey Questions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Dose Finding and Safety Study of Oral LEQ506 in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors|Recurrent or Refractory Medulloblastoma|Locally Advanced or Metastatic Basal Cell Carcinoma
Interventions: DRUG: LEQ506
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BO-112 and Pembrolizumab for the Treatment of PD-1/PD-L1 Refractory Liver Cancer
Status: TERMINATED
Conditions: Advanced Hepatocellular Carcinoma|BCLC Stage B Hepatocellular Carcinoma|BCLC Stage C Hepatocellular Carcinoma|Refractory Hepatocellular Carcinoma
Interventions: BIOLOGICAL: Nanoplexed Poly I:C BO-112|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of HAD Induction With Intensified Cytarabine in Newly-diagnosed CEBPA Double Mutated Acute Myeloid Leukemia
Status: RECRUITING
Conditions: CEBPA Double Mutation|Acute Myeloid Leukemia
Interventions: DRUG: HAD induction with intermediate dose cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Long-term Therapeutic Hypothermia for Poor-grade Aneurysmal Subarachnoid Hemorrhage
Status: UNKNOWN
Conditions: Hypothermia|Aneurysmal Subarachnoid Hemorrhage
Interventions: PROCEDURE: Zoll 2000 and/or CureWrap 3500 cooling system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer
Interventions: DRUG: Epacadostat|RADIATION: Short-course radiation|DRUG: CAPOX chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brief Cognitive Behavioral Therapy to Enhance Benzodiazepine Deprescribing
Status: RECRUITING
Conditions: Benzodiazepine Use|Insomnia|Anxiety
Interventions: OTHER: Benzodiazepine Medication Taper with Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of GM-CSF, Thalidomide Plus Docetaxel in Prostate Cancer
Status: TERMINATED
Conditions: Prostatic Neoplasms
Interventions: DRUG: GM-CSF|DRUG: thalidomide|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Single Ascending Dose of Adeno-associated Virus Serotype 8 Factor IX Gene Therapy in Adults With Hemophilia B
Status: ACTIVE_NOT_RECRUITING
Conditions: Hemophilia B
Interventions: BIOLOGICAL: AskBio009
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Photodynamic Therapy of Cutaneous Neoplastic Diseases Via Structured Illumination and Real-time Dosimetry.
Status: COMPLETED
Conditions: Skin Cancer|Signs and Symptoms
Interventions: DEVICE: Modulated Imaging (MI)|OTHER: Photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Extended Venous Thromboembolism Prophylaxis Comparing Rivaroxaban to Aspirin Following Total Hip and Knee Arthroplasty
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DRUG: rivaroxaban and ASA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Linperlisib Combined With Immunochemotherapy in Relapsed/Refractory LBCL
Status: RECRUITING
Conditions: Relapsed/Refractory Large B-Cell Lymphoma
Interventions: DRUG: Linperlisib|DRUG: Rituximab|DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Ifosfamide|DRUG: Carboplatin|DRUG: Etoposide|DRUG: Dexamethasone|DRUG: Cisplatin|DRUG: Ara-C|DRUG: Vinorelbine|DRUG: Mitoxantrone hydrochloride liposome
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictive Immune Biomarkers for COVID-19 Pathogenesis
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: Blood collection on admission and longitudinally|BIOLOGICAL: Blood collection on their first consultation and 10 to 14 days later
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: INTIBIA Pivotal Study
Status: RECRUITING
Conditions: Urinary Incontinence, Urge|Urinary Bladder, Overactive|Urinary Bladder Diseases|Urologic Diseases|Lower Urinary Tract Symptoms|Urological Manifestations
Interventions: DEVICE: INTIBIA Therapeutic|DEVICE: INTIBIA Non-Therapeutic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Blister Packaging Medication to Increase Treatment Adherence and Clinical Response
Status: COMPLETED
Conditions: Medication Adherence|Accidental Overdose|Deliberate Overdose|Suicide, Attempted
Interventions: OTHER: Blister packaging medications|OTHER: Dispense as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nivolumab Plus Ramucirumab in Patients With Recurrent, Advanced, Metastatic NSCLC
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Nivolumab|DRUG: Ramucirumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of N115 on Coughing in IPF Patients
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: 20mM sodium pyruvate nasal spray|OTHER: Saline Placebo control nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of rADAMTS-13 (SHP655) in the Treatment of Participants With Acquired Thrombotic Thrombocytopenic Purpura (aTTP)
Status: COMPLETED
Conditions: Acquired Thrombotic Thrombocytopenic Purpura (aTTP)
Interventions: OTHER: Placebo|DRUG: SHP655|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Online CBT Intervention for Students With Adjustment Disorder
Status: NOT_YET_RECRUITING
Conditions: Adjustment Disorders
Interventions: BEHAVIORAL: Internet CBT-UP intervention iCBT-UP|BEHAVIORAL: Internet Progressive Muscle Realxation Training (iPMR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sotatercept in Treating Patients With Myeloproliferative Neoplasm-Associated Myelofibrosis or Anemia
Status: COMPLETED
Conditions: Anemia|Myelodysplastic/Myeloproliferative Neoplasm|Myelofibrosis
Interventions: BIOLOGICAL: Sotatercept|DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Appraising the Embolization of Aneurysms Using Balt Optima™ Coil System (APPLY Study)
Status: UNKNOWN
Conditions: Aneurysm|Intracranial Aneurysm|Ruptured Aneurysm|Subarachnoid Hemorrhage, Aneurysmal|Cerebral Aneurysm Unruptured
Interventions: DEVICE: Optima Coil System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gut Microbe Composition, Exercise, and Breast Breast Cancer Survivors
Status: RECRUITING
Conditions: Breast Cancer|Gut Microbiome|Exercise|Fatigue
Interventions: OTHER: Aerobic Exercise Training|OTHER: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hypothalamic Functional Magnetic Resonance Imaging (fMRI) Response to Nutrients
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: glucose|DIETARY_SUPPLEMENT: fructose|DIETARY_SUPPLEMENT: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Modified Ketogenic Diet in Patients With McArdle Disease Part B
Status: COMPLETED
Conditions: McArdle Disease
Interventions: DIETARY_SUPPLEMENT: Ketocal 4:1 liquid Nutricia (intervention)|DIETARY_SUPPLEMENT: Fortini multifibre Nutrica (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic Vasculitis
Status: UNKNOWN
Conditions: Wegener's Granulomatosis|Microscopic Polyangiitis|Churg Strauss Syndrome|Polyarteritis Nodosa|Giant Cell Arteritis|Takayasu Arteritis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Spa Treatment, Outpatient Physiotherapy and no Physiotherapy in Spine Osteoarthritis
Status: COMPLETED
Conditions: Spine Osteoarthritis|Spa Resorts
Interventions: OTHER: Comprehensive physiotherapy including balneotherapy and filling questionaire|OTHER: Comprehensive physiotherapy without balneotherapy and filling questionaire|OTHER: No intervention, only filling questionaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Extension Study of the Safety and Efficacy of Multi-dose Intravenous ARC-520 in Patients With Chronic Hepatitis B (HBV) Infection
Status: TERMINATED
Conditions: Hepatitis B
Interventions: DRUG: ARC-520 Injection|DRUG: entecavir|DRUG: tenofovir|DRUG: antihistamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Gemcabene in Patients With Homozygous Familial Hypercholesterolemia on Stable, Lipid-Lowering Therapy (COBALT-1)
Status: COMPLETED
Conditions: Hypercholesteremia
Interventions: DRUG: Gemcabene
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Oxygen Therapy in Diabetics With Chronic Foot Ulcers and Improvement of Quality of Life
Status: COMPLETED
Conditions: Diabetic Foot Ulcer|Diabetes
Interventions: DEVICE: Hyperbaric oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Point of Care Device and Venous Blood International Normalized Ratio Measurements.
Status: TERMINATED
Conditions: Blood Coagulation Disorder
Interventions: DEVICE: Hemosense (PT/InR point of care device)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Clinical Trial of CSL's 2009 H1N1 Influenza Vaccine (CSL425) in Healthy Children
Status: COMPLETED
Conditions: Influenza Caused by the Novel Influenza A (H1N1) Virus
Interventions: BIOLOGICAL: CSL425|BIOLOGICAL: CSL425
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Peretinoin for Suppressing Recurrence of HCV-positive HCC
Status: COMPLETED
Conditions: Hepatic Neoplasm Malignant Recurrent
Interventions: DRUG: NIK-333(peretinoin)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Study of Intraperitoneal Docetaxel Plus S-1 for Malignant Ascites
Status: UNKNOWN
Conditions: Stomach Neoplasms|Peritoneal Metastasis
Interventions: DRUG: intraperitoneal docetaxel|DRUG: oral S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imaging Kidney Transplant Rejection Using Ferumoxytol-Enhanced Magnetic Resonance
Status: COMPLETED
Conditions: Renal Transplant Rejection
Interventions: DRUG: Feraheme|OTHER: MRI-GE Healthcare 3 Tesla magnet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of CX157 (TriRima) for the Treatment of Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: CX157 (TriRima)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Lebrikizumab in Adult Participants With Perennial Allergic Rhinitis (PREPARED-1)
Status: RECRUITING
Conditions: Perennial Allergic Rhinitis (PAR)
Interventions: DRUG: LY3650150|DRUG: Placebo|DRUG: Standard therapy for INCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gadofosveset Trisodium (Ablavar, Gdfos) in Distinguishing Hemangiomas and Metastases: A Prospective Trial
Status: UNKNOWN
Conditions: Cancer|Metastases|Liver Neoplasms
Interventions: OTHER: Liver MRI with Gdfos|OTHER: Liver MRI with EcGd
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Liking Adaptation to Beverages of Varying Sweetness Levels Following Prolonged Exposure
Status: COMPLETED
Conditions: Sweetness Liking Adaptation
Interventions: OTHER: Flavored carbonated soft drink (CSD) at different sweetness levels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Premenstrual Syndrome (PMS) and Mindfulness Stress Reduction Program (MSRP)
Status: COMPLETED
Conditions: Premenstrual Syndrome
Interventions: BEHAVIORAL: mindfulness stres reduction programe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Salt Intake and Antiproteinuric Effect of Paricalcitol in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Paricalcitol|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing the Efficacy of Venlafaxine XR Vs. SSRIs and Conventional Antidepressants in Depressed Patients
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Effexor|DRUG: SSRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel in Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: docetaxel, doxorubicin, cyclophosphamide|DRUG: Docetaxel,doxorubicin, cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Safety and Tolerability of Clascoterone Cream 1% in Healthy Chinese Adult Subjects
Status: NOT_YET_RECRUITING
Conditions: Acne Vulgaris
Interventions: DRUG: Clascoterone Cream 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Expanded Access Treatment Protocol of Enfortumab Vedotin in Subjects With Locally Advanced or Metastatic Urothelial Carcinoma
Status: APPROVED_FOR_MARKETING
Conditions: Locally Advanced or Metastatic Urothelial Carcinoma (UC)
Interventions: DRUG: enfortumab vedotin (EV)
Study Type: EXPANDED_ACCESS
Clinical trial: Safety Profile, MTD, and PK Profile Studies of ABT-263 When Administered in Combination With Standard and Weekly Regimens of Docetaxel in Subjects With Cancer
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: ABT-263|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of VX-661 in Combination With Ivacaftor on Chest Imaging Endpoints in Subjects With Cystic Fibrosis, Homozygous for the F508del CFTR Mutation
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Tezacaftor/Ivacaftor|DRUG: Ivacaftor|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Tolerability of an Oral Nutritional Supplement (PreOP Booster) Given Before Surgery
Status: COMPLETED
Conditions: Rectal Tumors
Interventions: DIETARY_SUPPLEMENT: PreOP Booster (food for special medical purposes)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison Study Using APAP With and Without SensAwake in Patients With OSA and PTSD
Status: COMPLETED
Conditions: Obstructive Sleep Apnea (OSA)|Post-Traumatic Stress Disorder (PTSD)
Interventions: DEVICE: AutoCPAP with SensAwake On|DEVICE: AutoCPAP with SensAwake Off
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of the T CD8 Immune Response in Horton's Disease
Status: COMPLETED
Conditions: Horton's Disease
Interventions: OTHER: Blood sample drawn into a 5 mL dry tube at the diagnosis and after 3 months of treatment|OTHER: 16 blood samples drawn into 6 mL heparinized tubes at the diagnosis and after 3 months of treatment|OTHER: Blood sample drawn into a 5 mL dry tube|OTHER: 16 blood samples drawn into 6 mL heparinized tubes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transarterial Chemoembolization for the Treatment of Lung Cancer
Status: RECRUITING
Conditions: Lung Non-Small Cell Carcinoma|Mediastinal Neoplasm|Pleural Neoplasm
Interventions: PROCEDURE: Computed Tomography|DRUG: Ethiodized Oil|DRUG: Mitomycin|PROCEDURE: Transarterial Chemoembolization|DEVICE: Tris-acryl Gelatin Microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Combined With Adebrelimab and Apatinib as the Perioperative Treatment in Patients With Biliary Tract Cancer
Status: RECRUITING
Conditions: Resectable Intrahepatic Cholangiocarcinoma With High Risk of Recurrence
Interventions: DRUG: Adebrelimab, Apatinib, Gemcitabine, cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety, Tolerability, and Antiviral Activity of GLS4 With Ritonavir in Patients With Chronic HBV Infection
Status: COMPLETED
Conditions: Chronic HBV Infection
Interventions: DRUG: GLS4|DRUG: RTV|DRUG: ETV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Spindles and Memory in Rolandic Epilepsy
Status: RECRUITING
Conditions: Rolandic Epilepsy|Rolandic Epilepsy, Benign|Centrotemporal Epilepsy|Centrotemporal; EEG Spikes, Epilepsy of Childhood|Epilepsy; Seizure|Epilepsy
Interventions: OTHER: Auditory stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Maintenance Treatment of Non Segmental Vitiligo With Tacrolimus Ointment 0.1% Versus Control
Status: TERMINATED
Conditions: Pigmentation Disorders|Vitiligo
Interventions: DRUG: Protopic|DRUG: Placebo : Diprobase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of AK104（ an Anti-PD-1 and Anti-CTLA-4 Bispecific Antibody) in Recurrent or Metastatic Cervical Cancer
Status: COMPLETED
Conditions: Recurrent or Metastatic Cervical Cancer
Interventions: BIOLOGICAL: AK104|BIOLOGICAL: Bevacizumab|DRUG: Paclitaxel|DRUG: Cisplatin or Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Spinal Stimulation Frequency on Spasticity, Motor Control, and Pain After Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: OTHER: Transcutaneous Spinal Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Supplementing Residential Substance Use Treatment With Written Exposure Therapy for Veterans With Post Traumatic Stress Disorder (PTSD) and Substance Use Disorders (SUD)
Status: RECRUITING
Conditions: PTSD|Substance Use Disorders
Interventions: BEHAVIORAL: Residential Written Exposure Therapy|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Convective Pre-warming on Intra-operative Thermoregulatory Capabilities
Status: TERMINATED
Conditions: Temperature Change, Body
Interventions: DEVICE: Bair Hugger™ Temperature Management Unit Model 750|DEVICE: 3M™ Bair Paws™ Flex Gown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Taste and Smell Dysfunction in Patients More Than Two Years After Start of Immune Checkpoint Inhibitor Therapy
Status: RECRUITING
Conditions: Melanoma|Non-small Cell Lung Cancer (NSCLC)|Urogenital Cancers
Interventions: OTHER: no intervention, only questionnaires, saliva collection and taste/smell tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Controlled Breathing Intervention to Reduce Stress and Improve Symptoms in COPD Patients (REST)
Status: RECRUITING
Conditions: COPD|Stress|Dyspnea
Interventions: BEHAVIORAL: REST|OTHER: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Long Term Effectiveness of Trigger Finger Injections With Triamcinolone vs. Dexamethasone
Status: COMPLETED
Conditions: Trigger Finger Disorder
Interventions: DRUG: Triamcinolone|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Patient Advocate to Improve Real-world Asthma Management for Inner City Adults
Status: COMPLETED
Conditions: Asthma|Communication
Interventions: BEHAVIORAL: Patient Advocate|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Three Modified-Release Formulations of RO4917523 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: RO4917523|DRUG: RO4917523|DRUG: RO4917523|DRUG: RO4917523
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Study to Determine the Fasting Bioequivalence of Reformulated OXY Tablets Manufactured at Two Different Facilities
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Reformulated OXY (Totowa) (oxycodone HCl)|DRUG: Reformulated OXY (Wilson) (oxycodone HCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy, Safety and Tolerability of CX157 in Treatment Resistant Depression
Status: COMPLETED
Conditions: Treatment Resistant Depression
Interventions: DRUG: Placebo|DRUG: CX157 (TriRima)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 2nd Autologous Stem Cell Transplant in Patients With Persistent/Recurrent (AL) Amyloidosis
Status: TERMINATED
Conditions: Multiple Myeloma|Plasma Cell Neoplasm
Interventions: BIOLOGICAL: filgrastim|DRUG: melphalan|PROCEDURE: autologous stem cell transplantation|PROCEDURE: stem cell infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Bushen Huatan Decoction in the Treatment of Polycystic Ovary Syndrome
Status: RECRUITING
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Bushen Huatan Decoction|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study of REGN5458 in Adult Patients With Relapsed or Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Linvoseltamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dexamethasone on Rebound Pain in Patients Receiving Ilioinguinal and Iliohypogastric Nerve Block
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: DRUG: Dexamethasone|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Proof-of-Concept Trial to Study the Safety and Activity of Linvoseltamab in Participants With Smoldering Multiple Myeloma at High Risk of Developing Multiple Myeloma
Status: RECRUITING
Conditions: Smoldering Multiple Myeloma (SMM)
Interventions: DRUG: Linvoseltamab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Lutein-enriched-egg Beverage on Age-Related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Age Related Macular Degeneration
Interventions: DIETARY_SUPPLEMENT: Lutein enriched eggs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: AZD6738 Plus Durvalumab in Biliary Tract Cancer
Status: RECRUITING
Conditions: Bile Duct Cancer|Chemotherapy Effect
Interventions: DRUG: AZD6738|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eculizumab for Prevention and Treatment of Kidney Graft Reperfusion Injury
Status: COMPLETED
Conditions: End-Stage Renal Disease|Kidney Failure|Graft Reperfusion Injury
Interventions: DRUG: eculizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Advancing Transplantation Outcomes in Children
Status: RECRUITING
Conditions: Kidney Transplant
Interventions: DRUG: Sirolimus|BIOLOGICAL: Belatacept|DRUG: Mycophenolate Mofetil|DRUG: Tacrolimus (Group1)|DRUG: Anti-Thymocyte Globulin (ATG)|DRUG: Tacrolimus (Group 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-component Intervention for Reducing Fear of Falling in Community-dwelling Older Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Fear of Falling
Interventions: BEHAVIORAL: Multi-component intervention|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zoledronic Acid in Patients With Multiple Myeloma and Asymptomatic Biochemical Relapse
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: zoledronic acid|OTHER: No treatment control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ofatumumab Versus Rituximab Salvage Chemoimmunotherapy Followed by Autologous Stem Cell Transplant in Relapsed or Refractory Diffuse Large B Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Large-Cell, Diffuse
Interventions: DRUG: OFATUMUMAB + DHAP|DRUG: RITUXIMAB + DHAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Properties of Absorbable and Nonabsorbable Suture Material in Dental Surgery
Status: UNKNOWN
Conditions: Suture Adverse Reaction|Suture; Complications, Mechanical|Suture Failure During Surgical Operation|Suture Related Complication|Suture Rupture|Suture; Complications, Infection or Inflammation|Suture Line Infection
Interventions: DRUG: Polyglycolic Acid|DRUG: Catgut|DRUG: Polytetrafluoroethylene|DRUG: Polyamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Rapid Sequence Intubation With Magnesium-rocuronium Compared With Succinylcholine - A Randomised Clinical Study
Status: COMPLETED
Conditions: Intubation Conditions
Interventions: DRUG: Magnesium perfusion|DRUG: Rocuronium|DRUG: Placebo perfusion|DRUG: Succinylcholine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect Of Nicotine on Neurocognitive Performance of Cigarette Smokers
Status: UNKNOWN
Conditions: Nicotine Dependence|Smoking|Tobacco Use Disorder|Nicotine Use Disorder
Interventions: DRUG: Nicotine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: To Assess the Safety, Tolerability and Efficacy of Itacitinib Immediate Release Tablets in Participants With Primary or Secondary Myelofibrosis Who Have Received Prior Ruxolitinib and/or Fedratinib Monotherapy (LIMBER-213)
Status: COMPLETED
Conditions: Myelofibrosis|Polycythemia Vera|Thrombocythemia
Interventions: DRUG: itacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Examine Safety, Tolerability and Effect on Body Weight of Subcutaneous AC2307 in Obese or Overweight Subjects
Status: COMPLETED
Conditions: Obesity|Overweight
Interventions: DRUG: AC2307|DRUG: placebo|DRUG: AC2307|DRUG: placebo|DRUG: AC2307|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial COmparing staNdard of Care Versus Treat to Target With telemonitoRing and Patient Education in Patients With Ulcerative cOlitis Initiating Adalimumab
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: Adalimumab|DIAGNOSTIC_TEST: Calprotectin|OTHER: e-Monitoring|OTHER: Therapy Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of PQ912 on the Pharmacokinetics of Midazolam and Omeprazole
Status: COMPLETED
Conditions: Healthy Volunteers|Pharmacologic Action
Interventions: DRUG: PQ912|DRUG: Midazolam|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fistiulation Rate Following Primary Cleft Repair≤
Status: COMPLETED
Conditions: Cleft Palate
Interventions: PROCEDURE: Buccinator myomucosal flap|PROCEDURE: Bardach two flap palatoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of ZYIL1 Oral Capsules for the Treatment of Patients With Mild to Moderately Active Ulcerative Colitis Resistant or Intolerant to Oral Aminosalicylates
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: Arm1|DRUG: Arm 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Single-Arm Pilot Study With Low-Dose Rituximab Plus Standard Oral Prednisone In Idiopathic Autoimmune Hemolytic Anemia
Status: COMPLETED
Conditions: Autoimmune Hemolytic Disease (Cold Type) (Warm Type)
Interventions: DRUG: prednisone, low dose rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of the Smart O2O Model Development for Chronic Diseases Management Through Digital Health
Status: NOT_YET_RECRUITING
Conditions: Hypertension|Diabete Mellitus
Interventions: BEHAVIORAL: O2O digital healthcare service
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Which Apparatus for Inhaled Pentamidine?
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: 500mg Amikacine (Amukin®) diluted in 4mL NaCl (0,9%)|DEVICE: Respirgard II|DEVICE: Isoneb®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Technology-Delivered Peer-to-Peer Support ART Adherence Intervention for Substance-using HIV+ Adults
Status: COMPLETED
Conditions: HIV
Interventions: BEHAVIORAL: Thrive With Me Control|BEHAVIORAL: Thrive With Me Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effect of Hypotensive Anaesthesia on Event Related Potentials, Quantitative Electroencephalograghy
Status: UNKNOWN
Conditions: Effect of Drugs
Interventions: DRUG: hypotensive anaesthesia using Nitroglycerine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Analgesic Effect of Combined Nerve Block and Systemic High Dose Glucocorticoid After Total Knee Arthroplasty.
Status: COMPLETED
Conditions: Peripheral Nerve Block|Pain
Interventions: DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Anesthesia Techniques to Reduce Nausea and Vomiting After Jaw Corrective Surgery
Status: COMPLETED
Conditions: Post-operative Nausea|Post-operative Vomiting|Nausea Persistent
Interventions: OTHER: Antiemetic anesthesia protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Investigator Initiated Study to Assess the Efficacy of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease Following Photorefractive Keratectomy (PRK)
Status: UNKNOWN
Conditions: Dry Eye
Interventions: DRUG: OC-01 (varenicline 0.6mg/ml) nasal spray|DRUG: Placebo (vehicle) Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Health Effects of Substituting Sugary Beverages With Artificially-sweetened Beverages or Water
Status: RECRUITING
Conditions: Body Weight
Interventions: BEHAVIORAL: Maintain usual SSBs|BEHAVIORAL: Substitute to non-SSBs|BEHAVIORAL: Study app|BEHAVIORAL: Beverage delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of Clamshells and Frog Pump Exercises
Status: COMPLETED
Conditions: Iliotibial Band Syndrome
Interventions: OTHER: Clamshell Exercise|OTHER: Frog pump exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Advice vs Advice + Exercise vs Advice + Exercise + Injection for Individuals With Plantar Fasciopathy
Status: COMPLETED
Conditions: Plantar Fasciopathy
Interventions: DRUG: Ultrasound-guided corticosteroid injection|OTHER: Heavy-slow resistance training|OTHER: Fundamental advice and a silicone heel cup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction of Labor With a Foley Balloon Catheter: Inflation With 30ml Compared to 60ml
Status: COMPLETED
Conditions: Induction of Labor
Interventions: PROCEDURE: Induction of labor with foley balloon - 60cc of saline|PROCEDURE: Induction of labor with foley balloon with 30cc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bazedoxifene as a Concomitant Treatment of Patients With Metastatic Pancreatic Adenocarcinoma
Status: UNKNOWN
Conditions: Pancreas Cancer
Interventions: DRUG: Bazedoxifene 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accessible Acupuncture for the Warrior With Acute Low Back Pain
Status: RECRUITING
Conditions: Acupuncture|Low Back Pain
Interventions: DRUG: NSAIDS|DEVICE: Battlefield Acupuncture|DEVICE: GV26 with manual tonification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Methylene Blue Mediated Photodynamic Therapy for Primary Localized Cutaneous Amyloidosis Treatment in Asians
Status: UNKNOWN
Conditions: Lichen Amyloidosis
Interventions: PROCEDURE: Methylene blue-mediated photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Closed-Loop Glucose Control in People With Type 1 Diabetes (BPK004)
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: Closed-Loop, Model Predictive Control (MPC)|DEVICE: Open-Loop
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Combination of Local Steroid Injection With Oral Steroid Administration for the Prevention on Esophageal Stricture After Endoscopic Submucosal Dissection for Early Esophageal Neoplasm
Status: COMPLETED
Conditions: Esophageal Stricture
Interventions: DRUG: combination of local steroid injection（triamcinolone ）with oral steroid administration（prednisone）|DRUG: oral steroid administration（prednisone）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study on the Immune Response and Safety of Various Potencies of an Investigational Chickenpox Vaccine Compared With a Marketed Chickenpox Vaccine, Given to Healthy Children 12 to 15 Months of Age
Status: COMPLETED
Conditions: Chickenpox
Interventions: BIOLOGICAL: Investigational varicella vaccine low potency|BIOLOGICAL: Investigational varicella vaccine medium potency|BIOLOGICAL: Investigational varicella vaccine high potency|BIOLOGICAL: Marketed varicella vaccine Lot 1|BIOLOGICAL: Marketed varicella vaccine Lot 2|BIOLOGICAL: Measles, mumps, and rubella vaccine|BIOLOGICAL: Hepatitis A vaccine|BIOLOGICAL: 13-valent pneumococcal conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Oral Administration of Ribavirin and Nitazoxamide Versus Placebo in COVID-19
Status: COMPLETED
Conditions: Covid19|SARS-CoV Infection
Interventions: DRUG: Placebo|DRUG: DuACT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Cerebrospinal Fluid Flow in Adolescent Idiopathic Scoliosis
Status: UNKNOWN
Conditions: Adolescent Idiopathic Scoliosis
Interventions: DIAGNOSTIC_TEST: Baseline Clinical Examination|RADIATION: Initial 3T MRI of the Brain and Spine|DIAGNOSTIC_TEST: 6-month Follow-up Clinical Examination|RADIATION: 6-month Follow-up 3T MRI of the Brain and Spine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ECM and Blood Components for Wound Healing
Status: TERMINATED
Conditions: Ulcer|Venous Ulcer|Foot Ulcer, Diabetic
Interventions: DEVICE: ECM|BIOLOGICAL: Blood Products|DEVICE: ECM in Blood Products
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT