pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Effect of Three Methods Used in Reducing Pain During Dressing Change
Status: COMPLETED
Conditions: Healthy
Interventions: BEHAVIORAL: mathematical operations|BEHAVIORAL: ball squeezing|BEHAVIORAL: listening to music|OTHER: kontrol grubu
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Pain Therapeutic Effects After Benign Mastectomy
Status: COMPLETED
Conditions: Pain, Postoperative|Mastectomy
Interventions: DRUG: Saline|DRUG: Opioid|DRUG: Opioid|DRUG: NSAID|DRUG: NSAID|DRUG: Opioid|DRUG: Opioid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-Label Study to Evaluate the Efficacy of ECP in Secondary Progressive Multiple Sclerosis
Status: TERMINATED
Conditions: Secondary Progressive Multiple Sclerosis
Interventions: DRUG: SoluMedrol|DEVICE: Extracorporeal Photopheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Scotchbond Universal Plus Compared to Scotchbond Universal With Filtek Universal Restorative to Restore Class V NCCLs
Status: ACTIVE_NOT_RECRUITING
Conditions: Class V Non-carious Cervical Dental Lesions
Interventions: DEVICE: Scotchbond Universal Plus Adhesive|DEVICE: Scotchbond Universal Adhesive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Emulsion Lipid Digestion & Satiety Study - Effect of Physical State and Acid Stability
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Acid stable emulsion with solid droplets|OTHER: Acid stable emulsion with liquid droplets|OTHER: Acid unstable emulsion with solid droplets|OTHER: Acid unstable emulsion with liquid droplets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Whole-Body Vibration on Balance in the Elderly Population
Status: COMPLETED
Conditions: Distorted; Balance
Interventions: DEVICE: Stochastic resonance whole-body vibration A|DEVICE: Stochastic resonance whole-body vibration b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Anti-eryptotic Effect of a Food Supplement With Plants Sterols in Hypercholesterolemia Treated With Statins
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases|Hypercholesterolemia|Atherosclerosis
Interventions: DIETARY_SUPPLEMENT: PS-containing dietary supplement|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Swine-origin A/H1N1 Influenza Vaccines in Healthy Europeans Children Aged 6 to 35 Months
Status: COMPLETED
Conditions: Influenza|Swine-origin A/H1N1 Influenza
Interventions: BIOLOGICAL: Swine A/H1N1 influenza vaccine (split virion, inactivated)|BIOLOGICAL: Swine A/H1N1 influenza vaccine (split virion, inactivated + Adjuvant)|BIOLOGICAL: Swine A/H1N1 influenza vaccine (split virion, inactivated + adjuvant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Treatment of SAM in Children 6-59 Months With RUTF and RUSF in Umerkot, Sindh, Pakistan
Status: WITHDRAWN
Conditions: Severe Acute Malnutrition
Interventions: DIETARY_SUPPLEMENT: Ready-to-use therapeutic food (RUTF)|DIETARY_SUPPLEMENT: Ready-to-use-supplementary food (RUSF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Liposomal Bupivacaine (Exparel) for Postoperative Pain Control for Open and Laparoscopic Abdominal Hernia Repair
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: EXPAREL|DRUG: Ketorolac|PROCEDURE: laparoscopic abdominal hernia repair|PROCEDURE: an open surgery for abdominal hernia repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety, Efficacy and Pharmacodynamic Effect of Bertilimumab in Patients With Bullous Pemphigoid
Status: COMPLETED
Conditions: Pemphigoid, Bullous
Interventions: BIOLOGICAL: Bertilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Simple Clinical Tool for Increasing Enrollment on a Kidney Transplant Waiting List for Patients Aged Over 70 and Initiating Dialysis
Status: TERMINATED
Conditions: Kidney Failure, Chronic
Interventions: OTHER: Systematic use of a prognostic score
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Neoadjuvant SBRT in Localized Advanced HNSCC
Status: RECRUITING
Conditions: Head and Neck Squamous Carcinoma
Interventions: RADIATION: SBRT+immunochemotherpy|DRUG: Immunochemotherapy|DRUG: cetuximab+immunochemotharpy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CALC-1 (Cetuximab in Advanced Lung Cancer): Study of 2 Methods of Combining Cetuximab and Gemcitabine in Patients With Advanced Non Small-cell Lung Cancer
Status: COMPLETED
Conditions: Advanced Non-Small Cell Lung Cancer
Interventions: DRUG: cetuximab|DRUG: gemcitabine|DRUG: gemcitabine|DRUG: cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 24-Week Induction Study of APT-1011 in Adult Subjects With Eosinophilic Esophagitis (EoE) (FLUTE 3)
Status: ACTIVE_NOT_RECRUITING
Conditions: Eosinophilic Esophagitis
Interventions: DRUG: APT-1011|DRUG: Placebo oral tablet|PROCEDURE: Esophagogastroduodenoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Thoracic Mobility Versus Stretching Exercise Program in Patients of Cervical Radiculopathy
Status: COMPLETED
Conditions: Cervical Radiculopathy
Interventions: OTHER: Thoracic mobility exercises with conventional physical therapy for cervical radiculopathy|OTHER: Thoracic stretching exercises with conventional physical therapy for cervical radiculopathy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation (tDCS) in the Treatment of Drug-naïve Obsessive-compulsive Disorder(OCD)
Status: UNKNOWN
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: high-definition transcranial direct current stimulation|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Effect of Food on Combination Dapagliflozin/Metformin Tablet in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Dapagliflozin/Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tislelizumab Plus Concurrent Chemoradiation in Older With ESCC
Status: RECRUITING
Conditions: Esophageal Cancer
Interventions: DRUG: Arm A|DRUG: Arm A|RADIATION: Arm A|DRUG: Arm B|RADIATION: Arm B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate Safety and Tolerability of BI 1744 CL in Free Dose Combination With Tiotropium Bromide Both Administered by Respimat® in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1744 CL|DRUG: Placebo|DRUG: Tiotropium bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Trial of Variable Dialysate Bicarbonate
Status: RECRUITING
Conditions: Peri-dialytic Cardiac Rhythms|Intradialytic Hypotension|Electrolyte Changes|pH Changes|Adverse Symptoms
Interventions: DRUG: Dialysate bicarbonate concentration|DEVICE: Dialysate bicarbonate concentration - telemetry monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Microbial Restoration in Inflammatory Bowel Diseases
Status: RECRUITING
Conditions: Fecal Microbiota Transplantation|Crohn Disease|Inflammatory Bowel Diseases|Microbiome
Interventions: DRUG: Antibiotics|DIETARY_SUPPLEMENT: Dietician designed diet|DRUG: FMT|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics (PK), Pharmacodynamics (PD), Safety, Tolerability of Multiple Dose Regimens of MT-3724 for the Treatment of Patients With Relapsed Chronic B-cell Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: WITHDRAWN
Conditions: Chronic B-cell Lymphocytic Leukemia|Small Lymphocytic Leukemia
Interventions: DRUG: MT-3724|DRUG: MT-3724|DRUG: MT-3724|DRUG: MT-3724|DRUG: MT-3724
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Geniculate Nerve Block Versus Adductor Canal Block for ACL Reconstruction Surgery
Status: RECRUITING
Conditions: ACL Tear|Pain, Postoperative
Interventions: PROCEDURE: Adductor canal block
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of the Inactivated, Split-Virion Influenza Vaccine, Northern Hemisphere 2008-2009 Formulation
Status: COMPLETED
Conditions: Influenza|Orthomyxoviridae Infections
Interventions: BIOLOGICAL: Split virion, inactivated Influenza vaccine|BIOLOGICAL: Split virion, inactivated Influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nicotine Treatment of Cognitive Decline in Down Syndrome
Status: COMPLETED
Conditions: Down Syndrome|Mild Cognitive Impairment
Interventions: DRUG: Low Dose Nicotine (7mg)|DRUG: Moderate Dose Nicotine (14mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Teclistamab With Other Anticancer Therapies in Participants With Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Teclistamab|DRUG: Daratumumab|DRUG: Pomalidomide|DRUG: Lenalidomide|DRUG: Bortezomib|DRUG: Nirogacestat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of the Internet Attachment-Based Compassion Therapy (iABCT)
Status: COMPLETED
Conditions: Mental Health Wellness 1|Compassion
Interventions: BEHAVIORAL: internet Attachment-Based Compassion Therapy (iABCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Multiple Ascending Doses (MAD) of Anti-A Disintegrin and Metalloproteinase With Thrombospondin Motifs-5 (Anti-ADAMTS-5) Nanobody in Participants With Knee Osteoarthritis (OA)
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: M6495|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study to Evaluate the Safety of Topically Applied Revera in Subjects With Venous Leg Ulcers
Status: COMPLETED
Conditions: Venous Stasis Ulcers
Interventions: DEVICE: Revera Wound Care|DEVICE: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Analgesia in Abdominal Surgery: a Medico-economic Study
Status: TERMINATED
Conditions: Extended Ileal Resection Under Laparotomy|Total Proctocolectomy Under Laparotomy|Colectomy Left/Right/Total Under Laparotomy|Rectosigmoidal Resection Under Laparotomy|Anterior Resection of Rectum Under Laparotomy|Abdomino-perineal Amputation Under Laparotomy
Interventions: PROCEDURE: epidural analgesia|PROCEDURE: PCA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interferon as a Mucosal Adjuvant for Influenza Vaccine Given Intranasally
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Trivalent inactivated influenza virus vaccine (2006-2007 formulation)|BIOLOGICAL: Type 1 interferon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Talonavicular Arthrodesis and Surgical Treatment of Ankle and Varus Foot
Status: COMPLETED
Conditions: Orthopedic Equine Varus Deformity
Interventions: PROCEDURE: arthrodesis talonavicular|PROCEDURE: tendon gestures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: KIDFIT: Keeping Ideal Cardiovascular Health Family Intervention Trial
Status: UNKNOWN
Conditions: Childhood Obesity|Weight Gain|Diet Modification
Interventions: BEHAVIORAL: KIDFIT HEALTHY|BEHAVIORAL: KIDFIT SAFE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: DDI Study of ASC41 in HV and the PK, Safety and Tolerability in Subjects With NAFLD.
Status: COMPLETED
Conditions: Healthy|NAFLD
Interventions: DRUG: ASC41|DRUG: Itraconazole|DRUG: Phenytoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Probiotics on Neonatal Hyperbilirubinemia
Status: COMPLETED
Conditions: Neonatal Hyperbilirubinemia
Interventions: BIOLOGICAL: Maflor®, Mamsel Pharmaceuticals, Turkey|OTHER: drops of saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety of Live SK08 Powder in Patients With IBS-D
Status: RECRUITING
Conditions: Irritable Bowel Syndrome With Diarrhea
Interventions: DRUG: Live SK08 powder|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison Between a PC and a CC Approach for the Placement of Infraclavicular Perineural Catheters in Hand Surgery
Status: RECRUITING
Conditions: Postoperative Pain|Anesthesia, Local
Interventions: PROCEDURE: Placement of an infraclavicular perineural catheter using a costoclavicular approach|PROCEDURE: Placement of an infraclavicular perineural catheter by paracoracoid approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Acute Administration of Bupropion on Neural Substrates Underlying Hedonic Capacity
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Bupropion|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Functional Outcome Between BQT and SBHT ACL Reconstruction
Status: COMPLETED
Conditions: Sports Injury|Anterior Cruciate Ligament Rupture
Interventions: PROCEDURE: Bone Quadriceps Tendon (BQT) arthroscopic-assisted ACL reconstruction|PROCEDURE: Single-Bundle Hamstring Tendon (SBHT) arthroscopic-assisted ACL reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subvastus vs. Medial Parapatellar Approaches in Total Knee Arthroplasty With Quadriceps Muscle Elastography
Status: COMPLETED
Conditions: Total Knee Arthroplasty
Interventions: PROCEDURE: Subvastus approach|PROCEDURE: Medial Parapatellar approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Perfusion of Gluteal Muscle in Patients With Intermittent Gluteal Claudication by Non-invasive MSOT
Status: RECRUITING
Conditions: Peripheral Vascular Diseases|Peripheral Arterial Disease|Intermittent Claudication|Gluteal Claudication
Interventions: DIAGNOSTIC_TEST: MSOT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Analgesia in Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Pain, Postoperative|Chronic Postoperative Pain
Interventions: DRUG: Ropivacaine 0.75|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dasatinib as Therapy for Myeloproliferative Disorders (MPDs)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes|Agnogenic Myeloid Metaplasia|Myelofibrosis|Hypereosinophilic Syndrome|Polycythemia Vera|Mastocytosis|Leukemia, Myelomonocytic, Chronic
Interventions: DRUG: Dasatinib (BMS-354825)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Study With MVA BN and Dryvax
Status: COMPLETED
Conditions: Smallpox
Interventions: BIOLOGICAL: Live vaccinia virus vaccine|BIOLOGICAL: MVA Smallpox Vaccine|BIOLOGICAL: MVA Smallpox Vaccine|OTHER: Placebo|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence Study Between Temozolomide Oral Suspension (Ped-TMZ) and Temodal® Capsules
Status: COMPLETED
Conditions: Therapeutic Equivalency
Interventions: DRUG: Ped-TMZ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial Evaluating the Use of the Laser-Assisted Immunotherapy (LIT/inCVAX) in Advanced Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer Stage IIIA|Breast Cancer, Stage IIIB|Breast Cancer Stage IV
Interventions: DRUG: 1% Glycated Chitosan|DEVICE: Photothermal Laser|DRUG: Placebo|DRUG: Cyclophosphamide|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Osimertinib and Bevacizumab Versus Osimertinib Alone as Second-line Treatment in Stage IIIb-IVb NSCLC With Confirmed EGFRm and T790M (BOOSTER)
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer Metastatic
Interventions: DRUG: Osimertinib|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Observational Study on Evaluating the Efficacy and Safety of Preemptive Antiviral Therapy With Tenofovir in HBsAg-positive Patients With Diffuse Large B-cell Lymphoma Receiving Rituximab-CHOP Chemotherapy (SPEED Study)
Status: UNKNOWN
Conditions: B-cell Lymphoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pulmonary Microbiota in Patients With Chronic Obstructive Pulmonary Disease Colonized With P. Aeruginosa Resistant to Imipenem
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: water used for oral wash|OTHER: sputum|OTHER: oral wash
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety, Efficacy, and Treatment Satisfaction Switching From Flolan to Remodulin Using the Crono Five Ambulatory Pump in Patients With PAH
Status: TERMINATED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: treprostinil|DEVICE: Crono Five ambulatory pump
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FES-induced Muscular Control of the Knee on Balance and Gait Retraining After a Stroke or a Cerebral Injury
Status: COMPLETED
Conditions: Hemiplegia|Gait, Hemiplegic|Gait, Unsteady|Rehabilitation
Interventions: OTHER: Functional Electrical Stimulation FES
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase II Single Arm Trial of Single-agent Vinflunine as Second-line Treatment of Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Vinflunine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Tiotropium Absorption From Tiotropium Easyhaler and Spiriva HandiHaler
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Tiotropium Bromide Monohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of a Probiotic on Microbiota Associated With the Immune System and Inflammation.
Status: RECRUITING
Conditions: Probiotic|Microbiota
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ultrasound for Neuraxial Anesthesia
Status: COMPLETED
Conditions: Lumbar Ultrasound
Interventions: DEVICE: Detection of the puncture site by ultrasound scan of the lumbar spine.|PROCEDURE: Detection of the puncture site by identification of the landmarks.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: RAD001 in Combination With PKC412 in Patients With Relapsed, Refractory or Poor Prognosis AML or MDS
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: RAD001|DRUG: PKC412
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety/Efficacy of Antibiotic Steroid Combination in Treatment of Blepharitis and/or Keratitis and/or Conjunctivitis
Status: COMPLETED
Conditions: Blepharitis|Conjunctivitis|Keratitis
Interventions: DRUG: Moxifloxacin and Dexamethasone combined|DRUG: Moxifloxacin|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Canakinumab Administered for 6 Months (24 Weeks) in Japanese Patients With Cryopyrin-associated Periodic Syndromes Followed by an Extension Phase
Status: COMPLETED
Conditions: Cryopyrin-associated Periodic Syndromes|Familial Cold Autoinflammatory Syndrome|Muckle-Wells Syndrome|Neonatal Onset Multisystem Inflammatory Disease
Interventions: DRUG: canakinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Assess the Effect of an Intervention Integrating Contingency Management (Financial Incentives) to Enhance Hepatitis C Treatment Uptake Following Dried Blood Spot Hepatitis C RNA Testing Among People With Recent Injecting Drug Use Attending Needle and Syringe Programs
Status: UNKNOWN
Conditions: Hepatitis C, Chronic
Interventions: BEHAVIORAL: Incentive payment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Cerebroprotective Effect of Melatonin in Stroke
Status: RECRUITING
Conditions: Stroke, Acute Ischemic|Strokes Thrombotic
Interventions: DRUG: Melatonin 10 MG|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: THE INFLUENCE OF COGNITIVE BEHAVIORAL THERAPY IN SEXUAL DYSFUNCTION FEMALE: Randomized Clinical Trial
Status: RECRUITING
Conditions: Sexual Dysfunctions
Interventions: BEHAVIORAL: Cognitive behavioral therapy (CBT)|BEHAVIORAL: Control therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Metformin on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen Excess
Status: RECRUITING
Conditions: Obesity|Hyperandrogenemia|Polycystic Ovary Syndrome
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of 405nm Blue Light Emitting Diode in the Treatment of Women With Vulvovaginal Candidiasis: a Clinical Trial
Status: RECRUITING
Conditions: Candidiasis, Vulvovaginal
Interventions: DEVICE: Blue LED 405 nm|OTHER: Questionnaire of anamnesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Operations Research of the 'Real World' Effectiveness of Multi-Month Dispensing of ART for Stable Patients in CARGs in Zimbabwe
Status: UNKNOWN
Conditions: HIV/AIDS
Interventions: OTHER: Three month dispensing of ART in CARGs|OTHER: Six month dispensing of ART in CARGs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Which Therapy for Acute Heart Attacks? (The WEST Study)
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: tenecteplase|DRUG: enoxaparin|DRUG: clopidogrel|PROCEDURE: percutaneous coronary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Proprietary Water on Physiological and Perceptual Responses
Status: COMPLETED
Conditions: Hydration|Dehydration
Interventions: DIETARY_SUPPLEMENT: proprietary water|OTHER: Active comparator|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: The Effects of Different Doses of Dexmedetomidine on Propofol Requirement for Loss of Consciousness Undergoing Bispectral Index: a Double-blinded, Placebo-controlled Trial
Status: COMPLETED
Conditions: Loss of Consciousness
Interventions: OTHER: normal saline|DRUG: dexmedetomidine 0.5 µg/kg|DRUG: dexmedetomidine 1.0 µg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mini-dose Dexmedetomidine-Esketamine Infusion and Perioperative Sleep Quality
Status: RECRUITING
Conditions: Old Age|Knee Replacement Surgery|Hip Replacement Surgery|Dexmedetomidine|Esketamine|Sleep Quality
Interventions: DRUG: Dexmedetomidine|DRUG: Esketamine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Severe COVID-19
Status: UNKNOWN
Conditions: 2019 Novel Coronavirus Pneumonia|COVID-19
Interventions: BIOLOGICAL: UC-MSCs|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polish Transcatheter Aortic Valve-in-Valve Implantation (ViV-TAVI) Registry
Status: UNKNOWN
Conditions: Aortic Valve Stenosis|Aortic Valve Insufficiency|Ventricular Outflow Obstruction, Left
Interventions: DEVICE: Transcatheter Aortic Valve-in-Valve Implantation (ViV-TAVI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Abiraterone Acetate Dose-Escalation Study in Hormone Refractory Prostate Cancer
Status: COMPLETED
Conditions: Prostate Neoplasms
Interventions: DRUG: Abiraterone acetate|DRUG: Abiraterone acetate|DRUG: prednisone/prednisolone or dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjunct Dexmedetomidine (Precedex®) Therapy Impact on Sedative and Analgesic Requirement
Status: WITHDRAWN
Conditions: Sedation|Analgesia
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does Fetal Fibronectin and Ultrasound Cervical Length Help in the Evaluation of Women With Suspected Preterm Labor?
Status: COMPLETED
Conditions: Preterm Birth
Interventions: PROCEDURE: Transvaginal ultrasound cervical length|PROCEDURE: Cervicovaginal fetal fibronectin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Eicosapentaenoic Acid on Endothelial Function in Diabetic Subjects
Status: TERMINATED
Conditions: Type 2 Diabetes|Coronary Artery Disease
Interventions: DRUG: Icosapent ethyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Temperament, Anxiety and Depression on Immuninity in Colorectal Cancer Patients. Effetti Del Temperamento, Dell'Ansia e Della Depressione Sulla Sopravvivenza Globale e Sulla Risposta Immunitaria Del Paziente Affetto da Adenocarcinoma Colo-Rettale.
Status: COMPLETED
Conditions: Temperament|Anxiety|Depression|Colorectal Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Study for CML Who Failed Prior TKIs or With T315I Mutation or Ph+ ALL Who Failed Prior TKIs or With T315I Mutation
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Myeloid Leukemia|Acute Lymphoblastic Leukemia
Interventions: DRUG: Ponatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tilt-Table Study of the Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension
Status: COMPLETED
Conditions: Orthostatic Hypotension
Interventions: DRUG: Midodrine HCl|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The SMARTEX Heart Failure Study
Status: COMPLETED
Conditions: Heart Failure
Interventions: BEHAVIORAL: high-intensity interval training|BEHAVIORAL: Moderate continuous training|BEHAVIORAL: Recommendation of regular moderate exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxytocin Infusion and Abdominal Myomectomy
Status: COMPLETED
Conditions: Oxytocin and Abdominal Myomectomy
Interventions: OTHER: oxytocin in abdominal myomectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Bevacizumab in Treating Patients With Recurrent or Progressive Meningiomas
Status: COMPLETED
Conditions: Acoustic Schwannoma|Adult Anaplastic Meningioma|Adult Ependymoma|Adult Grade I Meningioma|Adult Grade II Meningioma|Adult Meningeal Hemangiopericytoma|Adult Papillary Meningioma|Neurofibromatosis Type 1|Neurofibromatosis Type 2|Recurrent Adult Brain Tumor
Interventions: BIOLOGICAL: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: QOL and GI Outcomes in Malignancies
Status: RECRUITING
Conditions: Psychological Adaptation|Psychological Adjustment|Stress, Emotional
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy (CBT)-based skills|BEHAVIORAL: Standard Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing the Digestion of Milk With Different Beta-casein Protein Content by Dairy Intolerant Persons
Status: COMPLETED
Conditions: Dairy Intolerance
Interventions: OTHER: Lactose free milk|OTHER: Jersey milk|OTHER: High A1 β-casein milk|OTHER: High A2 β-casein milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Oral Itraconazole Versus Combination of Systemic Glucorticoids and Oral Itraconazole in CPA-ABPA Overlap Syndrome
Status: RECRUITING
Conditions: Chronic Pulmonary Aspergillosis|Allergic Bronchopulmonary Aspergillosis
Interventions: DRUG: Prednisone tablet and Itraconazole|DRUG: Oral itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Training Secondary School Students as Anti-smoke Ambassadors Using the Service-learning Model
Status: RECRUITING
Conditions: Smoking Cessation
Interventions: OTHER: 'Learning while serving' training program|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation (HaploHCT) Following Reduced Intensity Conditioning (RIC) for Selected High Risk Non-Malignant Diseases
Status: TERMINATED
Conditions: Sickle Cell Disease|Thalassemia|High Risk Hematologic Disorders|Cerebral Adrenoleukodystrophy|Inherited Metabolic Disorders
Interventions: PROCEDURE: Blood and Marrow Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rollover Study of Cenicriviroc for the Treatment of Liver Fibrosis in Participants With Nonalcoholic Steatohepatitis
Status: TERMINATED
Conditions: Nonalcoholic Steatohepatitis|Liver Cirrhosis|Non-alcoholic Fatty Liver Disease
Interventions: DRUG: Cenicriviroc
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Resection With Gliadel Wafer Followed by Dendritic Cells Vaccination for Malignant Glioma Patients
Status: COMPLETED
Conditions: Malignant Glioma
Interventions: BIOLOGICAL: Dendritic cell Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monopolar and Bipolar Current RFA Knife in POEM
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophageal Motility Disorders
Interventions: PROCEDURE: Per-oral Endoscopic Myotomy|DEVICE: Speedboat (Bipolar electrocautery knife)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Active Immunization of HIV-Infected Pregnant Women: A Phase I Study of Safety and Immunogenicity of a rgp120/HIV-1 Vaccine (NOTE: Some Patients Receive Placebo)
Status: WITHDRAWN
Conditions: HIV Infections|Pregnancy|HIV Seronegativity
Interventions: BIOLOGICAL: MF59|BIOLOGICAL: rgp120/HIV-1 SF-2
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: PREVENTION
Clinical trial: Effect of Dietary Fat When Eaten With Fructose Versus Glucose
Status: COMPLETED
Conditions: Body Weight Changes
Interventions: OTHER: 40% Fat Diet, 20% Fructose Beverage|OTHER: 20% Glucose Beverage|OTHER: 20% Glucose Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical and Functional Outcomes at Least 2 Years After Hamstring Muscle Repair
Status: COMPLETED
Conditions: Hamstring Muscle Repair|Hamstring Rupture
Interventions: OTHER: data collection by health questionnaires|OTHER: assessment of muscle strength|OTHER: assessment of gait|OTHER: assessment of squatting and single leg hops|OTHER: assessment of postural stability
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: Telisotuzumab Vedotin|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Famciclovir Oral Pediatric Formulation in Children 1-12 Years of Age With Varicella Zoster Infection
Status: COMPLETED
Conditions: Chickenpox|Herpes Zoster
Interventions: DRUG: famciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Attention Patterns in Young People With Anxiety
Status: UNKNOWN
Conditions: Anxiety|Adolescent Behavior
Interventions: BEHAVIORAL: Gaze-Contingent Music Reward Training|BEHAVIORAL: Control Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hypofractionated Proton Beam Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With Stage II-III Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: RADIATION: Proton beam radiation therapy (PBT)|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of the Symetis ACURATE Neo/TF Compared to the Edwards SAPIEN 3 Bioprosthesis.
Status: COMPLETED
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: Symetis ACURATE neo/TF transfemoral TAVI system|DEVICE: Edwards Sapien 3 Transcatheter Heart Valve
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supplementation of Oil Palm Phenolics to Healthy Participants
Status: UNKNOWN
Conditions: Cardiovascular Diseases|Hyperlipidemias|Hypercholesterolemia
Interventions: DRUG: Placebos|DIETARY_SUPPLEMENT: Oil Palm Phenolics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: TCM Conservative Treatment for the Degenerative Lumbar Spinal Stenosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Degenerative Lumbar Spinal Stenosis
Interventions: BEHAVIORAL: Traditional Chinese medicinal ointment|BEHAVIORAL: Acupotomy|BEHAVIORAL: Cupping therapy with bamboo cup|OTHER: Oral Chinese medicine granules|BEHAVIORAL: Epidural Steroid Injections (ESIs)|BEHAVIORAL: Interferential current therapy|BEHAVIORAL: Thermal therapy|OTHER: Oral painkillers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Platelet Function Monitoring in Patients Treated With Clopidogrel at the Time of Primary Percutaneous Coronary Angioplasty
Status: COMPLETED
Conditions: Platelet Reactivity
Interventions: DRUG: Clopidogrel|DRUG: Clopidogrel|DRUG: Clopidogrel|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Comparison of Urinary Incontinence During Third Trimester of Nulliparous on Pelvic Floor Muscle Training
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: OTHER: PFMT|OTHER: non PFMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Intravitreal Ranibizumab on Visual Acuity and Hard Exudate Resolution in the Treatment of Diabetic Macular Edema With Center Involved Edema and Lipid Exudates
Status: COMPLETED
Conditions: Diabetic Macular Edema|Hard Lipid Exudates
Interventions: DRUG: ranibizumab 0.3mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of the "Haemoblock" in Pacemaker Patients
Status: COMPLETED
Conditions: Hematoma Postoperative
Interventions: PROCEDURE: Pacemaker implantation|DRUG: Haemostatic solution "Haemoblock" application|DRUG: Saline solution application|DIAGNOSTIC_TEST: Ultrasound of pacemaker pocket|DIAGNOSTIC_TEST: Blood sampling|DIAGNOSTIC_TEST: Echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Panic Disorder Among Individuals Consulting Emergency Departments for Non Cardiac Chest Pain
Status: UNKNOWN
Conditions: Panic Disorder|Anxiety Disorder|Mental Disorder
Interventions: BEHAVIORAL: Brief cognitive-behavioral treatment for Panic Disorder|BEHAVIORAL: Cognitive-Behavior Therapy for Panic Disorder|DRUG: paroxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Recombinant Non-immunogenic Staphylokinase vs Placebo in Patients With COVID-19 - FORRIF Trial
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Recombinant nonimmunogenic staphylokinase|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of Nivolumab to Standard Treatment for Patients With Metastatic or Unresectable Colorectal Cancer That Have a BRAF Mutation
Status: RECRUITING
Conditions: Metastatic Colon Adenocarcinoma|Metastatic Rectal Adenocarcinoma|Stage III Colon Cancer AJCC v8|Stage III Rectal Cancer AJCC v8|Stage IV Colon Cancer AJCC v8|Stage IV Rectal Cancer AJCC v8|Unresectable Colon Adenocarcinoma|Unresectable Rectal Adenocarcinoma
Interventions: BIOLOGICAL: Cetuximab|DRUG: Encorafenib|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Infiltration Versus Block Against Pains After High Tibial Osteotomy
Status: COMPLETED
Conditions: Osteoarthritis|Malalignment
Interventions: DRUG: Ropivacaine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Among Erythropoietin Stimulating Agents
Status: COMPLETED
Conditions: Anemia of End Stage Renal Disease
Interventions: DRUG: Epoetin alpha or beta (Epoetin group)|DRUG: Darbepoetin alfa|DRUG: Methoxy polyethylene glycol-epoetin beta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protein for Life: Towards a Focused Dietary Framework for Healthy Ageing. Consumer Assessment of High Protein Biscuits
Status: UNKNOWN
Conditions: Acceptance, Social
Interventions: DIETARY_SUPPLEMENT: Biscuit acceptance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Preoxygenation With Optiflow™ - the Effect of Speech on Lung Oxygenation.
Status: COMPLETED
Conditions: Unrecognized Condition
Interventions: DEVICE: Optiflow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Metformin Hydrochloride in Preventing Breast Cancer in Patients With Atypical Hyperplasia or In Situ Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Atypical Ductal Breast Hyperplasia|BRCA1 Mutation Carrier|BRCA2 Mutation Carrier|Ductal Breast Carcinoma in Situ|Lobular Breast Carcinoma in Situ
Interventions: DRUG: metformin hydrochloride|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess Pharmacokinetics and Pharmacodynamics Following Administration of BAY1093884 in Patients With Severe Hemophilia
Status: COMPLETED
Conditions: Hemophilia A; Hemophilia B
Interventions: DRUG: BAY1093884|DRUG: BAY1093884
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Efficacy and Safety of Brodalumab in Subjects With Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: 210 mg brodalumab|DRUG: 140 mg brodalumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT