pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Comparison of Knee Osteoarthritis Treatment With Bone Marrow Aspirate Concentrate , Leukocyte Rich Platelet Rich Plasma and Hyaluronic Acid
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Bone Marrow Aspirate Concentrate|PROCEDURE: Leukocyte Rich Platelet Rich Plasma|DRUG: Hyaluronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study of an Otic Formulation in Acute Otitis Externa
Status: COMPLETED
Conditions: Acute Otitis Externa
Interventions: DRUG: Moxidex otic solution|DRUG: Moxifloxacin otic solution|DRUG: Dexamethasone phosphate otic solution|DEVICE: Tympanostomy tubes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of BI 2536 With Pemetrexed in Previously Treated Patients With Non-small-cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: BI 2536|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Flow Nasal Cannula Weaning in Acute Bronchiolitis
Status: RECRUITING
Conditions: Acute Bronchiolitis
Interventions: OTHER: High flow nasal cannula immediate ending|OTHER: High flow nasal cannula weaning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Interleukin (IL)- 4R-alpha Inhibition on Respiratory Microbiome and Immunologic Correlates in Severe Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Dupilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: cTBS on First-episode Drug Naive Patients With Schizophrenia
Status: ACTIVE_NOT_RECRUITING
Conditions: Schizophrenia
Interventions: DEVICE: transcranial magnetic stimulation|DEVICE: sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EEG Results of Deep TMS in Patients With OCD
Status: UNKNOWN
Conditions: Obsessive-Compulsive Disorder|EEG With Periodic Abnormalities
Interventions: DEVICE: Deep Transcranial Magnetic Stimulation|DRUG: Paroxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Factors Associated With Falling in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: Baseline assessment of demographic, anthropometric and clinical characteristics|OTHER: Baseline assessment of demographic, anthropometric and clinical characteristics|OTHER: Locomotor assessments|OTHER: Speech assessments|OTHER: Audiology assessments
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Quantiferon-TB Gold in the Assessment of Latent TB in Patients Candidate to Treatment or Treated With TNFα Antagonists
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Spondylarthritis|Tuberculosis
Interventions: PROCEDURE: Quantiferon-TB Gold assay|PROCEDURE: Tuberculin skin test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Open-label Study to Assess the Effectiveness of Pirfenidone in Participants With Idiopathic Pulmonary Fibrosis (IPF).
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Pirfenidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tezosentan in the Treatment of Acute Heart Failure
Status: COMPLETED
Conditions: Acute Heart Failure|Acute Decompensation of Chronic Heart Failure|New Onset of Heart Failure
Interventions: DRUG: tezosentan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mental Practice in Chronic, Stroke Induced Hemiparesis
Status: COMPLETED
Conditions: Hemiparesis
Interventions: BEHAVIORAL: Mental Practice Group|BEHAVIORAL: Active Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Vitamin D Supplementation Combined With Alarm Therapy in Treating Nocturnal Enuresis
Status: NOT_YET_RECRUITING
Conditions: Enuresis
Interventions: BEHAVIORAL: alarm therapy|DRUG: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Keep On Keep Up Bladder Health: Co-creating and Testing a Self-management Technological Solution for Ageing Well
Status: NOT_YET_RECRUITING
Conditions: Urinary Incontinence in Old Age
Interventions: BEHAVIORAL: KOKU Bladder|BEHAVIORAL: recommendations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The COMPASS Study: A Study of Volanesorsen (Formally ISIS-APOCIIIRx) in Patients With Hypertriglyceridemia
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DRUG: Volanesorsen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Granulocyte Colony Stimulating Factor And Growth Hormone In Cirrhosis Of Liver: An Open Label Study
Status: COMPLETED
Conditions: Cirrhosis
Interventions: DRUG: standard medical therapy|DRUG: G-CSF|DRUG: Growth Hormone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development and Feasibility Testing of Digital Theory-based Pursed Lip Breathing in Stable Patients With COPD
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: Digital pursed lip breathing intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Transcendental Meditation and PTSD
Status: UNKNOWN
Conditions: Ptsd|Depressive Symptoms|Suicidal Ideation|Alcohol Use, Unspecified
Interventions: BEHAVIORAL: TM|BEHAVIORAL: PCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Body Mass Index on the Hyperemic Response to Regadenoson
Status: COMPLETED
Conditions: Obesity|Endothelial Dysfunction|Decreased Vascular Flow
Interventions: DRUG: Adenosine|DRUG: Regadenoson
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Low-protein Infant Formula With Partial or Extensive Proteinhydrolysate 4 Year Follow-up
Status: COMPLETED
Conditions: Disturbance of Growth
Interventions: OTHER: control formula|OTHER: intervention formula 1|OTHER: intervention formula 2|OTHER: intervention formula 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: enLighten Laser With MLA Handpiece for Treatment of Moderate and Severe Acne Scars
Status: COMPLETED
Conditions: Acne Scars - Mixed Atrophic and Hypertrophic
Interventions: DEVICE: other
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Protein Disrupted in Schizophrenia 1 (DISC1) as a Novel Biomarker for Cardiac Disease
Status: RECRUITING
Conditions: Heart Diseases|Heart; Functional Disturbance|Schizophrenia
Interventions: DIAGNOSTIC_TEST: Echocardiography|DIAGNOSTIC_TEST: Cardiac Magnetic Resonance Imaging|DIAGNOSTIC_TEST: Electrocardiography|OTHER: Blood sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chemotherapy Combined With Radiotherapy Versus Radiotherapy Alone for Solitary Plasmacytoma
Status: RECRUITING
Conditions: Solitary Plasmacytoma
Interventions: RADIATION: radiotherapy|DRUG: Bortezomib Injection|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Predictive Value of Prostate Spherical Volume Ratio in Lower Urinary Tract Symptoms and Clinical Progression of Benign Prostatic Hyperplasia:A Single-center Paired Validating Confirmatory Study
Status: COMPLETED
Conditions: Lower Urinary Tract Symptoms，Prostatic Hyperplasia
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Compare the Pharmacokinetics and the Safety Between a Fixed-dose Combination Administration of "BR3005" and Co-administration of "BR3005-1" and "BR3005-2" Under Fed Conditions in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Type2 Diabetes Mellitus
Interventions: DRUG: BR3005|DRUG: BR3005-1|DRUG: BR3005-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fetoscopic Repair of Isolated Fetal Spina Bifida
Status: ACTIVE_NOT_RECRUITING
Conditions: Spina Bifida|Myelomeningocele|Chiari Malformation Type 2|Neural Tube Defects|Spinal Dysraphism|Congenital Abnormality
Interventions: DEVICE: Fetoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metabolic Mapping to Measure Retinal Metabolism
Status: COMPLETED
Conditions: Macular Degeneration|Diabetic Retinopathy|Hippel-Landau Disease|Mitochondria
Interventions: PROCEDURE: Feasibility Study - Imaging System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dopaminergic Enhancement of Rehabilitation Therapy Early After Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Telerehabilitation|DRUG: Sinemet Pill|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Simvastatin for the Treatment of COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Subcutaneous Immunotherapy in Patients Sensitized to Phleum Pratense
Status: COMPLETED
Conditions: Allergic Rhinoconjunctivitis
Interventions: BIOLOGICAL: Subcutaneous immunotherapy with Phleum pratense pollen extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Technique For Gall Bladder Fundus Retraction In Single Incision Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Gallbladder Diseases
Interventions: PROCEDURE: cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin for Carpal Tunnel Syndrome
Status: WITHDRAWN
Conditions: Carpal Tunnel Syndrome
Interventions: DRUG: Botulinum toxin|DRUG: Corticosteroid injection into Carpal Tunnel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quality of Life and Functional Performance in Children With Spastic Cerebral Palsy
Status: UNKNOWN
Conditions: Evaluations
Interventions: OTHER: Gross motor function classification System (GMFCS)|OTHER: Arabic Version of Zarit burden Inventory measure|OTHER: Arabic Version of Chalder Fatigue Scale (CFQ version 11)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Informational Meetings for Planning and Coordinating Treatment
Status: RECRUITING
Conditions: End of Life|Communication|Cancer Metastatic
Interventions: OTHER: Novel Communication Intervention|OTHER: Enhanced Usual Care Parent Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ventilatory Effect on Speed of Anesthesia Under Various Inhaled Anesthetics
Status: COMPLETED
Conditions: Pharmacokinetics of Inhaled Anesthetics
Interventions: DRUG: Sevoflurane|DRUG: Desflurane|DRUG: Isoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Skin Care Strategies for Neonatal Jaundice Phototherapy to Prevent Atopic Dermatitis in Moderate and Severe Infants
Status: UNKNOWN
Conditions: Neonatal Jaundice|Atopic Dermatitis
Interventions: COMBINATION_PRODUCT: Use baby moisturizers by NeoChine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Identification of Markers for Determining the Efficacy of Vitamin D Receptor Activator Therapy in Stage 3/4 CKD Patients
Status: COMPLETED
Conditions: CKD Stage 3/4
Interventions: DRUG: Vitamin D 2mg daily for 2 weeks oral paricalcitol|DRUG: Placebo
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use of Prokinetics in Early Enteral Feeding in Preterm Infants
Status: WITHDRAWN
Conditions: Feeding Disorder|Nutrition Disorder|Infant,Premature
Interventions: DRUG: Metclopramide|DRUG: Erythromycin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: National, Multicentric Registry Study on Neuroimmunological Diseases in China
Status: RECRUITING
Conditions: Multiple Sclerosis|NMO Spectrum Disorder|Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease|Myasthenia Gravis|Autoimmune Encephalitis|Acute Disseminated Encephalomyelitis
Interventions: OTHER: Data collection and follow-up observation|OTHER: Data collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comparative Study of Different Hypothermic Circulatory Arrest Strategies on Aortic Surgery.
Status: UNKNOWN
Conditions: Morality|Hypothermic Circulatory Arrest Time|Aortic-cross Clamping Time|Cardiopulmonary Bypass Time|Operation Time|Re-Thoracotomy|ICU Stay|Mechanical Ventilation Time|Blood Transfusion|Neurological Disorder|Dialysis|Aneurysm|Endoleak|Hospital Stay
Interventions: PROCEDURE: the temperature of hypothermic circulatory arrest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cough Desensitization Therapy for Cough Hypersensitivity Syndrome
Status: COMPLETED
Conditions: Cough
Interventions: BIOLOGICAL: Supra-threshold and progressive doses of diluted capsaicin via a Koko Digidoser nebulizer|BIOLOGICAL: Sub-threshold doses of diluted capsiacin via a KoKo Digidoser nebulizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study of ID Fellow-based VS. Pharmacist-based Antibiotic Pre-authorization
Status: COMPLETED
Conditions: All Hospitalzied Patients|No Specific Conditions Requires
Interventions: PROCEDURE: ID fellow-based antibiotic pre-authorization|PROCEDURE: Pharmacist-based antibiotic pre-authorization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Covid-19 Vaccination in Adolescents and Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Covid19
Interventions: BIOLOGICAL: Tozinameran|BIOLOGICAL: CoronaVac|BIOLOGICAL: CoronaVac, intradermal
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Remote-controlled Capsule Endoscopy: a Feasibility Study
Status: UNKNOWN
Conditions: Gastric Ulcer|Gastric Polyp
Interventions: DEVICE: magnetic-controlled capsule endoscopy(Navicam)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: B6 Treatment for Nausea and Vomiting in Pregnancy
Status: UNKNOWN
Conditions: Nausea and Vomiting Complain in Early Pregnancy
Interventions: DRUG: vitamin B6|DRUG: vitamin B6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Acalabrutinib, Umbralisib, and Ublituximab (AU2) In Relapsed and Untreated CLL
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|Relapsed Chronic Lymphocytic Leukemia|Refractory Chronic Lymphocytic Leukemia
Interventions: DRUG: Acalabrutinib|DRUG: Umbralisib|DRUG: Ublituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surveillance of High-grade Non-muscle Invasive Bladder Tumours Using the Xpert Bladder Cancer Monitor
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-muscle Invasive Bladder Cancer|Urinary Biomarker
Interventions: DIAGNOSTIC_TEST: Xpert Bladder Cancer Monitor|DIAGNOSTIC_TEST: Flexible cystoscopy (WL/NBI) and urinary cytology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Continuation Trial for Subjects With Lupus That Completed Protocol HGS1006-C1056 or HGS1006-C1057
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: belimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determinants of Virological Response After Discontinuation of Nucleoside Analogue Therapy in Hepatitis B Patients
Status: UNKNOWN
Conditions: Chronic Hepatitis B.
Interventions: DRUG: Nucleoside Analogue therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine, Cisplatin, and Bevacizumab in Treating Patients With Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: cisplatin|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Y-90, Capecitabine, and Atezolizumab for Oligometastatic CRC
Status: NOT_YET_RECRUITING
Conditions: Colorectal Carcinoma Metastatic in the Liver
Interventions: COMBINATION_PRODUCT: yttrium-90 radioembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-arm Trial of Roxadustat Combined With Retinoic Acid in the Treatment of Refractory Low-risk MDS
Status: NOT_YET_RECRUITING
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Roxadustat in combination with retinoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Clinical Trial to Determine the Efficacy of Vitamin D for Acne Therapy"
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Calcipotriene|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Coenzyme q10 in Pediatrics With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DIETARY_SUPPLEMENT: Coenzyme Q10|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Body Weight on Reproductive Outcomes in Poor Ovarian Responders in ICSI Cycles
Status: UNKNOWN
Conditions: Invitro Fertilization
Interventions: DRUG: Gonadotropins|DRUG: GNRH antagonist|DRUG: Human chorionic gonadotropin Chorimon|DRUG: Natural progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Vemurafenib Plus Cobimetinib Plus PEG-interferon in Advanced Melanoma Patients Harboring the V600BRAF Mutation
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Vemurafenib|DRUG: Peg-interferon|DRUG: Cobimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Sugammadex in Magnesium Pretreated Patients
Status: COMPLETED
Conditions: Neuromuscular Block
Interventions: DRUG: Magnesium Sulfate|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cannabidiol Oral Solution for the Treatment of Patients With Prader-Willi Syndrome
Status: TERMINATED
Conditions: Prader-Willi Syndrome
Interventions: DRUG: Cannabidiol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Helicobacter Pylori Sample Collection Protocol Post Therapy Subjects
Status: COMPLETED
Conditions: Helicobacter Pylori Infection|Gastric Ulcer|Nausea|Abdominal Pain|Weight Loss|Stomach Ulcer|Loss of Appetite|Bloating
Interventions: OTHER: Post-Therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vitamin D3 and the Stress-axis in MS
Status: TERMINATED
Conditions: Multiple Sclerosis
Interventions: DRUG: Cholecalciferol|OTHER: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of Pre-exposure Treatment With Hydroxy-Chloroquine on the Risk and Severity of COVID-19 Infection
Status: UNKNOWN
Conditions: COVID-19
Interventions: DIAGNOSTIC_TEST: COVID 19 serology|OTHER: COVID 19 Self-Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Studying Biomarkers in Samples From Younger Patients With Wilms Tumor
Status: COMPLETED
Conditions: Kidney Cancer
Interventions: GENETIC: gene expression analysis|GENETIC: proteomic profiling|GENETIC: reverse transcriptase-polymerase chain reaction|GENETIC: western blotting|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|PROCEDURE: spectroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dietary Phytosterols and Human Aortic Valve
Status: UNKNOWN
Conditions: Hypercholesterolemia|Atherosclerosis
Interventions: DIETARY_SUPPLEMENT: Dietary plant stanols|DIETARY_SUPPLEMENT: Dietary plant sterols|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CS-1008 Used With Irinotecan Versus Irinotecan Alone in Subjects With Metastatic Colorectal Carcinoma Who Failed First-line Treatment With Oxaliplatin
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: CS-1008|DRUG: irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Custom-Made Biomechanical Perturbation Platform on Kinetics, Kinematics and Electromyography in Healthy Subjects
Status: UNKNOWN
Conditions: Healthy
Interventions: DEVICE: APOS biomechanical gait system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds (PRIMARY)
Status: RECRUITING
Conditions: Mitral Valve Regurgitation
Interventions: PROCEDURE: Mitral valve repair|DEVICE: Transcatheter edge-to-edge repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Immune Globulin Treatment Compared to Placebo in Patients With Myasthenia Gravis
Status: COMPLETED
Conditions: Myasthenia Gravis
Interventions: DRUG: Intravenous ImmuneGlobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: AWARE Intervention: Feasibility and Efficacy Trial at Three University Health Services Centers
Status: COMPLETED
Conditions: Depression|Anxiety|PTSD|Suicidal Ideation|Substance Use Disorders|Unsafe Sex|Coping Behavior
Interventions: BEHAVIORAL: AWARE intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Radiation Therapy in Treating Patients With Recurrent Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficiency of Interferential Current Application Methods in Chronic Neck Pain
Status: RECRUITING
Conditions: Chronic Neck Pain
Interventions: DEVICE: Sham vacuum|DEVICE: Interferential Current Therapy Vacuum Electrodes|DEVICE: Interferential Current Therapy Carbon-silicon Pad Electrodes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioural Experiments for Generalized Anxiety in Adolescents - Pilot Study
Status: RECRUITING
Conditions: Generalized Anxiety Disorder|Adolescent - Emotional Problem
Interventions: BEHAVIORAL: Behavioural Experiments for Intolerance of Uncertainty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Utah Study Evaluating Apneic Oxygenation for Emergency Department Intubation
Status: UNKNOWN
Conditions: Intubation
Interventions: OTHER: Apneic oxygenation|OTHER: Pre-oxgenation with NRB, NIPPV, BVM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Biological and Clinical Efficacy of Shingrix in Patients With CLL
Status: NOT_YET_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|CLL-like MBL|Varicella-zoster Virus Reactivation
Interventions: BIOLOGICAL: serologic response evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phenylephrine vs. Norepinephrine Infusion After Spinal Anesthesia for Cesarean Delivery
Status: COMPLETED
Conditions: Effects of; Anesthesia, in Labor and Delivery
Interventions: DRUG: Phenylephrine|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Closure Techniques and Scar Appearance
Status: WITHDRAWN
Conditions: Wound Closure Techniques
Interventions: PROCEDURE: Running polypropylene closure|PROCEDURE: Tissue Adhesive (Derma-Bond)|PROCEDURE: Subcuticular polyglactin-910 combined with tissue adhesive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characteristics and Treatment Patterns of Patients With Chronic Obstructive Pulmonary Disease (COPD), Initiating Tio+Olo or Other Maintenance Therapies in the US and the UK: A Retrospective Claims Database Study
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium bromide + Olodaterol|DEVICE: Sp(t)iolto® Respimat®
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lenvatinib+Letrozole Versus Fulvestrant in Metastatic ER+/HER2- Breast Cancer, Post Progression on Al + CDK4/6 Inhibitor
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Lenvatinib + Letrozole|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Restrictive Fluid Management In Liver Transplantation (REFIL)
Status: RECRUITING
Conditions: Liver Transplantation
Interventions: PROCEDURE: Low splanchnic blood volume restrictive fluid management strategy|PROCEDURE: Optimized cardiac output liberal fluid management strategy|PROCEDURE: Phlebotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Induced Hypertension for Delayed Cerebral Ischaemia After Aneurysmal Subarachnoid Haemorrhage:a Feasibility Study
Status: TERMINATED
Conditions: Cerebral Ischemia|Subarachnoid Hemorrhage
Interventions: DRUG: Induced hypertension with norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Buccinator Myomucosal Flap With Furlow Palatoplasty and VPI
Status: RECRUITING
Conditions: Velopharyngeal Insufficiency
Interventions: PROCEDURE: Buccinator myomucosal flap with Furlow palatoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hepatic Impairment Study With MDV3100 in Subjects With Mild and Moderate Hepatic Impairment Compared to a Healthy Control Group
Status: COMPLETED
Conditions: Pharmacokinetics of MDV3100|Healthy Subjects|Kidney Diseases
Interventions: DRUG: MDV3100
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Multiple-dose Pharmacokinetics Study of "SYN006 HFA MDI" Administered Orally to Healthy Volunteers
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Budesonide/Procaterol 180/10 X 4 puffs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Airway Dimension Study in Children Undergoing MRI Sedated With Propofol and Dexmedetomidine
Status: TERMINATED
Conditions: Airway Remodeling
Interventions: DRUG: Dexmedetomidine|DRUG: propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison: Constant-rate Infusion Plus Demanding Dosing VS Variable-rate Feedback Infusion Plus Demanding Dosing
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DEVICE: Variable-rate Feedback Infusion mode|DEVICE: Constant-rate Infusion mode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Oxford Marfan Trial
Status: UNKNOWN
Conditions: Marfan Syndrome
Interventions: DRUG: Irbesartan 150-300mg capsules daily for 6 months|DRUG: Doxycycline 100-200mg capsules daily for 6 months|DRUG: Doxycycline placebo capsules daily for 6 months|DRUG: Irbesartan placebo capsules daily for 6 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brentuximab Vedotin, Cyclosporine, and Verapamil Hydrochloride in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma
Status: COMPLETED
Conditions: Recurrent Hodgkin Lymphoma|Refractory Hodgkin Lymphoma
Interventions: DRUG: Brentuximab Vedotin|DRUG: Cyclosporine|OTHER: Pharmacokinetic Study|DRUG: Verapamil|DRUG: Verapamil Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Trial to Assess the Efficacy, Acceptability and Safety of Moviprep® Versus a 4L PEG+E Standard Solution
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: Macrogol3350 NA sulphate NACl KCl ascorbic acid NA ascorbate|DRUG: Macrogol3350 Na sulphate Na bicarbonate NaCl KCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stromal Cell Therapy For The Treatment Of Acute Respiratory Distress Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: ARDS, Human|COVID
Interventions: DRUG: Mesenchymal Stromal Stem Cells - KI-MSC-PL-205
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Insulin NPH and Insulin Aspart in Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin aspart|DRUG: soluble human insulin|DRUG: insulin NPH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IPACK or Selective Tibial Nerve Block for ACL Reconstruction With an Adductor Canal Block
Status: RECRUITING
Conditions: Analgesia
Interventions: PROCEDURE: Selective tibial nerve block|PROCEDURE: IPACK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Topical Cysteamine and Fractional 1927nm Low-Powered Diode Laser for Treatment of Facial Melasma
Status: RECRUITING
Conditions: Melasma
Interventions: DEVICE: Fractional 1927nm Low-Powered Diode Laser|OTHER: Topical Cysteamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients.
Status: COMPLETED
Conditions: Death, Sudden, Cardiac|Ventricular Fibrillation|Tachycardia|Atrial Fibrillation|Sick Sinus Syndrome
Interventions: DEVICE: Defibrillator, Dual Chamber ; Implantable|PROCEDURE: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of a Combination of Four Drugs in Patients With Recent HIV Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Indinavir sulfate|DRUG: Abacavir sulfate|DRUG: Amprenavir|DRUG: Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STEP: Proglide® Versus Femoseal®: A Trial to Compare the Efficacy of Arterial Closure Devices Following Endovascular Peripheral Arterial Procedures
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: OTHER: Arterial closure to ensure hemostasis at femoral artery puncture points|DEVICE: Proglide® (Abbott)|DEVICE: Femoseal® (Terumo)|OTHER: Arterial closure to ensure hemostasis at femoral artery puncture points
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Ultrasound-guided Genicular Nerve Block With Phenol for the Treatment of Chronic Pain Due to Knee Osteoarthritis
Status: UNKNOWN
Conditions: Osteoarthritis, Knee|Chronic Pain
Interventions: DRUG: Phenol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Tolerability of Long-Acting Nifedipine Gastrointestinal Therapeutic System in Chronic Kidney Disease With Uncontrolled Hypertension Patients, a Prospective, Multicenter, Observational Study
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Nifedipine controlled-release tablets(Nifedipine GITS, ADALAT, BAYA1040)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Whole-brain Irradiation With Chloroquine for Brain Metastases
Status: TERMINATED
Conditions: Brain Metastasis
Interventions: DRUG: Chloroquine|RADIATION: Total brain radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lurasidone HCl A Phase 3 Study of Patients With Acute Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Lurasidone|DRUG: Olanzapine|DRUG: Placebo comparator|DRUG: Lurasidone 40 mg tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel, Potent and Non-addictive Analgesic of Combinations for Knee Replacement Moderate to Severe Pain Management
Status: ENROLLING_BY_INVITATION
Conditions: Pain, Postoperative
Interventions: DRUG: Naldebain|DRUG: SafeTynadol|DRUG: Naldebain + SafeTynadol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Electromyography Evaluation of the Impacts of Different Insoles in the Activity Patterns of the Lower Limb Muscles
Status: COMPLETED
Conditions: Electromyography|Muscles|Foot Orthoses
Interventions: OTHER: Foot insoles
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Low Intensity Extracorporeal Low Energy Shock Wave Therapy on Stress Urinary Incontinence and Overactivity Bladder
Status: UNKNOWN
Conditions: Stress Urinary Incontinence|Overactive Bladder
Interventions: DEVICE: DUOLITH SD1-TOP focused shock wave system (STORZ MEDICAL EvoTronTM, GA)-Sham arm|DEVICE: DUOLITH SD1-TOP focused shock wave system (STORZ MEDICAL EvoTronTM, GA)-LiESWT arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy & Safety Study of Pregabalin to Treat Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)
Status: UNKNOWN
Conditions: Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)
Interventions: DRUG: Pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: "Natural" and "Organic" Cigarette Descriptors: Association With Expectancies, Subjective Effects, Topography, and Biomarkers of Exposure Among Daily Smokers
Status: RECRUITING
Conditions: Smoking Behaviors
Interventions: OTHER: Cigarette trial
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Treprostinil Iontophoresis in Systemic Sclerosis Digital UlcErations. A Proof of Concept Study
Status: COMPLETED
Conditions: Scleroderma, Systemic
Interventions: DRUG: Iontophoresis of treprostinil|DRUG: Iontophoresis of placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Mechanical Ventilation on the Diaphragm in COVID-19 Intensive Care Patients. A Post-mortem Pathology Study
Status: UNKNOWN
Conditions: Diaphragm Injury|Pathology|COVID-19 Acute Respiratory Distress Syndrome|Ventilation Therapy; Complications
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial of Lutein for Patients With Retinitis Pigmentosa Receiving Vitamin A
Status: COMPLETED
Conditions: Retinitis Pigmentosa
Interventions: DRUG: Lutein|DIETARY_SUPPLEMENT: Cornstarch control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical & Web-based Diet & Activity Counseling for Men
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Diet and physical activity interventions|BEHAVIORAL: Computer technology to tailor, promote and sustain health behavior change & improve health care delivery.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of Azvudine in Preventing SARS-Cov-2 Infection in Household Contacts of Covid-19
Status: RECRUITING
Conditions: SARS-CoV-2 Infection
Interventions: DRUG: Azvudine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Toy IV Catheter on Children's Pain, Fear and Emotional Indicators
Status: COMPLETED
Conditions: Intravenous Catheterization
Interventions: OTHER: Children Preparation With a Toy IV Catheter Before Peripheral Cannula application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intraosseous Vancomycin in Primary Total Hip Arthroplasty - Designing a Protocol
Status: COMPLETED
Conditions: Prosthetic Joint Infection|Vancomycin|Joint Diseases
Interventions: DRUG: Experimental Intraosseous vancomycin 500mg in 250 mL NS|DRUG: Standard IV administration of vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Drug-drug Interaction Study to Evaluate the Effect of ISIS 681257 on Warfarin
Status: COMPLETED
Conditions: Elevated Lipoprotein(a)|Cardiovascular Diseases
Interventions: DRUG: ISIS 681257|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy Study of Intrasphincteric Autologous Myoblast Injection to Treat Stress Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: BIOLOGICAL: Transurethral intrasphincteric autologous myoblast implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study to Evaluate the Pharmacokinetics and Safety Following SC Administration of DWJ108J in Patients With Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DRUG: Leuprolide Acetate|DRUG: Leuprolide Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Social-networking-site(SNS) Based Weight Loss Behavior Intervention- the Effect of Social Network and Multi-level Factors on Weight Loss
Status: COMPLETED
Conditions: Weight Loss
Interventions: BEHAVIORAL: Enhanced intervention via social networking site (SNS)|BEHAVIORAL: Standard intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Intranasal Oxytocin in Frontotemporal Dementia
Status: COMPLETED
Conditions: Frontotemporal Dementia
Interventions: DRUG: oxytocin|DRUG: Saline Nasal Mist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lu's Acupuncture and Moxibustion Treatment on Stroke
Status: UNKNOWN
Conditions: Ischemic Stroke|Paralysis
Interventions: PROCEDURE: Acupuncture|PROCEDURE: Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Resistance Training and Cardiometabolic Health
Status: TERMINATED
Conditions: Insulin Sensitivity|Endothelial Dysfunction|Blood Pressure
Interventions: OTHER: High Load/Low Rep Resistance Training|OTHER: Low Load/High Rep Resistance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prospective Analysis of Effect of Collagen Wrap Conduit on Radial and Ulnar Nerve Function Following Radial/Ulnar Forearm Free Flap Harvest
Status: WITHDRAWN
Conditions: Head and Neck Neoplasms|Dysesthesia
Interventions: DEVICE: Collagen Nerve Wrap Conduit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study to Compare Continuous Infusion of Interferon With Standard of Care for Chronic Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: interferon alfa-2b|DRUG: peginterferon alfa-2b|DRUG: ribavirin, USP|DEVICE: external drug infusion pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT