pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Dose-Deescalated 3-Fraction Stereotactic Body Radiotherapy For Centrally Located Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: RADIATION: 45 Gray (Gy) regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RMC-5552 Monotherapy in Adult Subjects With Recurrent Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma|Recurrent Glioblastoma
Interventions: DRUG: RMC-5552
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Cannulation In Children During Sevoflurane Induction
Status: COMPLETED
Conditions: Intravenous Cannulation|Sevoflurane Induction|Child
Interventions: OTHER: Intravenous Cannulation (iv placement)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: City of Rochester Teen Outreach Program (TOP™) Evaluation
Status: COMPLETED
Conditions: Adolescent Problems|Sex Behavior|Academic Underachievement Disorder of Childhood or Adolescence
Interventions: BEHAVIORAL: TOP|BEHAVIORAL: Control intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Guided Self-help for Binge Eating
Status: COMPLETED
Conditions: Bulimia Nervosa|Eating Disorder Not Otherwise Specified|Binge Eating Disorder
Interventions: OTHER: Face-to-face self-help|OTHER: E-mail self-help|OTHER: Waiting List
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Sympathetic Mechanisms in Obesity-Crossover Design
Status: RECRUITING
Conditions: Obesity|Hypertension
Interventions: DRUG: Amlodipine|DRUG: Moxonidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: rFVIII-Fc (Produced by AryoGen Pharmed Co.) Pharmacokinetic Study
Status: COMPLETED
Conditions: Severe Hemophilia A
Interventions: DRUG: Factor VIII, recombinant human with Fc fusion (rFVIII-Fc)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Vibration Stimulation on Intramuscular Injection Pain and Patient Satisfaction: A Single-blind, Randomized Cross-over Study
Status: UNKNOWN
Conditions: Pain
Interventions: DEVICE: Vibrating Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Daily IL-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Graft-versus-host Disease
Interventions: DRUG: Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Factors Associated With the Occurrence of Severe Forms of COVID-19 Infection in Patients With Inflammatory Rheumatism or Autoimmune Diseases
Status: UNKNOWN
Conditions: SARS-CoV2 Infection|Rare Diseases|Chronic Inflammatory Rheumatism|Autoimmune Diseases
Interventions: OTHER: no intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase II Trial of Stereotactic Radiation Therapy (SRT) Versus SRT Plus Vertebral Augmentation Procedure (VAP) for Vertebral Metastasis
Status: TERMINATED
Conditions: Vertebral Metastasis
Interventions: RADIATION: Stereotactic Radiation Therapy|RADIATION: SRT with Vertebral Augmentation Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of ELISA Assay on Human Papilloma Viruses (HPV) Infection Population
Status: UNKNOWN
Conditions: Patient With Invasive Cervical Carcinoma|Patient With CIN Lesion|Patient With HPV Infected Patients Without Histopathologic Lesion|Normal Populations.
Interventions: PROCEDURE: peripheral blood isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clomiphene Citrate (CC)/Gonadotropin/Gonadotropin Releasing Hormone (GnRH) Antagonist Versus Gonadotropin/GnRH Agonist
Status: COMPLETED
Conditions: Ovarian Stimulation
Interventions: DRUG: clomiphene citrate|PROCEDURE: Ultrasound|DRUG: GnRH antagonist|DRUG: gonadotopin (HMG)|DRUG: buserelin|DRUG: rFSH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Lactobacillus Reuteri and Nystatin Prophylaxis on Candida Colonization and Infection in Very Low Birth Weight Infants
Status: COMPLETED
Conditions: Very Low Birth Weight Infants
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri|DRUG: Nystatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study to Compare Efficacy and Safety of TEV-45779 With XOLAIR (Omalizumab) in Adults With Chronic Idiopathic Urticaria
Status: COMPLETED
Conditions: Chronic Urticaria
Interventions: COMBINATION_PRODUCT: TEV-45779|COMBINATION_PRODUCT: XOLAIR® Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Novel Therapeutics for Acute Remedy of Colitis
Status: NOT_YET_RECRUITING
Conditions: Ulcerative Colitis|Ulcerative Colitis Chronic Moderate|Ulcerative Colitis Chronic Severe
Interventions: DRUG: BRS201
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Video-Based Versus Written Patient Education on Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis|Atopic Eczema|Infantile Eczema|Hand Eczema
Interventions: OTHER: Patient Educational Materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose:
Clinical trial: ProMRI AFFIRM Study of the EVIA/ENTOVIS Pacemaker With Safio S Pacemaker Leads
Status: COMPLETED
Conditions: Cardiac Disease
Interventions: PROCEDURE: Evia/Entovis pacemaker system under Magnetic Resonance Imaging (MRI) conditions
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Blood Glucose Control With BioChaperone Insulin Lispro Compared to Insulin Lispro (Humalog®) After Ingestion of a Standardized Meal
Status: COMPLETED
Conditions: Diabetes Mellitus Type 1
Interventions: DRUG: BioChaperone insulin lispro|DRUG: Humalog®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hormone Therapy and Combination Chemotherapy Before and After Surgery in Treating Patients With Stage I-IIIA Breast Cancer
Status: TERMINATED
Conditions: Estrogen Receptor-positive Breast Cancer|HER2-negative Breast Cancer|Progesterone Receptor-positive Breast Cancer|Stage I Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer
Interventions: DRUG: exemestane|DRUG: triptorelin pamoate|DRUG: capecitabine|DRUG: methotrexate|DRUG: vinorelbine tartrate|DRUG: paclitaxel|PROCEDURE: therapeutic conventional surgery|RADIATION: radiation therapy|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SHR-A1921 for Injection in Patients With Platinum-Resistant Recurrent Epithelial Ovarian Cancer
Status: RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: SHR-A1921|DRUG: Doxorubicin|DRUG: Paclitaxel|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visceral Abdominal Fat, Non Alcoholic Fatty Liver Diseases and Asymptomatic Coronary Atherosclerosis
Status: UNKNOWN
Conditions: Visceral Fat|Fatty Liver|Atherosclerosis|Coronary Computed Tomography Angiography
Interventions: PROCEDURE: excess of visceral fat|PROCEDURE: patients with NAFLD
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Liposomal Bupivacaine With Dexamethasone for Foot Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Foot Surgery|Ankle Surgery|Post Operative Pain|Popliteal Nerve Block
Interventions: DRUG: Exparel 266 MG Per 20 ML Injection|DRUG: Bupivacaine Hcl 0.75% Inj|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Study to Evaluate the Safety of Dutogliptin/PHX1149T in Subjects With Type 2 Diabetes Mellitus
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus|Type 2 Diabetes
Interventions: DRUG: dutogliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Basic Life Support (BLS) Training by Homemade Manikin
Status: COMPLETED
Conditions: Cardiopulmonary Arrest With Successful Resuscitation|Education, Nursing
Interventions: OTHER: CPR training with e-learning with a handmade mannequin.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: COVID-19: SARS-CoV-2 Specific Memory B and T-CD4+ Cells
Status: UNKNOWN
Conditions: COVID-19|SARS-CoV-2 Infection
Interventions: OTHER: 35 ml blood, 5 tubes LITHIUM HEPARINATE at each time (hospitalized Patients )|OTHER: 35 ml blood, 5 tubes LITHIUM HEPARINATE at each time (cured Patients)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Mirror Therapy With Virtual Reality Application on Motor-Sense Acquisition and Quality of Live in Home Care of Stroke Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Stroke Syndrome
Interventions: DIAGNOSTIC_TEST: Mirror Therapy with Virtual Reality Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Brief Acceptance and Commitment Therapy (ACT) for Perinatal Anxiety
Status: COMPLETED
Conditions: Post Partum Depression|Perinatal Depression|Post Partum Anxiety|Perinatal Anxiety
Interventions: DIAGNOSTIC_TEST: Baseline Assessment (18-26 weeks pregnant)|BEHAVIORAL: Online Intervention and Phone Coaching Interventions|DIAGNOSTIC_TEST: Follow Up Assessments: 34-36 weeks pregnant and 4-week postpartum|DIAGNOSTIC_TEST: Follow Up Assessments: 8 weeks postpartum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Continuous Femoral and Tibial Nerve Blocks in TKA Patients
Status: TERMINATED
Conditions: Analgesia in Total Knee Arthroplasty
Interventions: DRUG: Ropivicaine|DEVICE: Continuous Femoral Nerve Catheter|DEVICE: Continuous Tibial Nerve Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety, Completion Rate and Prevention Effect by Rifamycin-containing Regimens for Latent Tuberculosis Infection in Patients With Kidney Transplantation: a Prospective Intervention Pilot Study
Status: RECRUITING
Conditions: Pulmonology
Interventions: DRUG: Rifamycin-containing regimen|DRUG: Rifamycin-free regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Evaluation of Dai Dai Flower on Body Weight
Status: COMPLETED
Conditions: Gastroenterology
Interventions: DIETARY_SUPPLEMENT: Placebo drink|DIETARY_SUPPLEMENT: Dai Dai flower drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Stereotactic Ablative Radiotherapy in Synchronous and Metachronous Oligo-Metastatic Non Small Cell Lung Cancer
Status: RECRUITING
Conditions: NSCLC|NSCLC Stage IV|Oligometastatic Disease|Non Small Cell Lung Cancer|Non Small Cell Lung Cancer Metastatic|EGF-R Positive Non-Small Cell Lung Cancer|NSCLC Stage IV Without EGFR/ALK Mutation|Non-Small Cell Adenocarcinoma|Non-Small Cell Squamous Lung Cancer|Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor|Synchronous Metastases|Metachronous Metastasis
Interventions: RADIATION: Stereotactic Ablative Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erlotinib Hydrochloride in Treating Participants With Muscle Invasive or Recurrent Urothelial Cancer
Status: COMPLETED
Conditions: Recurrent Bladder Urothelial Carcinoma|Recurrent Renal Pelvis Urothelial Carcinoma|Recurrent Ureter Urothelial Carcinoma|Recurrent Urethral Urothelial Carcinoma|Stage 0a Bladder Cancer AJCC v8|Stage 0a Renal Pelvis Cancer AJCC v8|Stage 0a Ureter Cancer AJCC v8|Stage 0a Urethral Cancer AJCC v8|Stage 0is Bladder Cancer AJCC v8|Stage 0is Renal Pelvis Cancer AJCC v8|Stage 0is Ureter Cancer AJCC v8|Stage 0is Urethral Cancer AJCC v8|Stage II Bladder Cancer AJCC v8|Stage II Renal Pelvis Cancer AJCC v8|Stage II Ureter Cancer AJCC v8|Stage II Urethral Cancer AJCC v8|Stage III Renal Pelvis Cancer AJCC v8|Stage III Ureter Cancer AJCC v8|Stage III Urethral Cancer AJCC v8|Stage IIIA Bladder Cancer AJCC v8
Interventions: DRUG: Erlotinib Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Folfoxiri Plus Bevacizumab Followed by Chemoradiotherapy Plus Bevacizumab in Patients With Resectable Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DRUG: FOLFOXIRI plus Bevacizumab|OTHER: Chemoradiotherapy plus Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Frequency of Putative Enteric Zoster Diagnosed Using Saliva Samples in Patients With Abdominal Pain: a Prospective Study
Status: COMPLETED
Conditions: Abdominal Pain|Zoster With Other Complications
Interventions: DIAGNOSTIC_TEST: Salivary VZV-DNA PCR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Doula in Nulliparas and Multiparas
Status: COMPLETED
Conditions: Labor Pain
Interventions: BEHAVIORAL: Doula|BEHAVIORAL: Doula
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I Study of the Safety and Immunogenicity of Rgp 120/HIV-1IIIB Vaccine in HIV-1 Seropositive Adult Volunteers
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: rgp120/HIV-1IIIB
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Application of Somatostatin for Advanced Gastric Cancer After D2 Lymph Node Dissection
Status: COMPLETED
Conditions: Gastric Cancer After D2 Lymph Node Dissection
Interventions: DRUG: Somatostatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Long-Term Maintenance Treatment With Once Daily Crisaborole Ointment 2% in Pediatric and Adult Participants With Mild-to-Moderate Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Crisaborole 2%|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Long-term Active Treatment Study of Mongersen (GED-0301) in Subjects With Crohn's Disease
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: DRUG: GED-0301|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: In Vivo Study of Neuroinflammation in Tobaccosmoking: a Clinical PET Study of TSPO Using [18F]PBR111
Status: NOT_YET_RECRUITING
Conditions: Dosimetry|Healthy
Interventions: DRUG: [18F]PBR111|PROCEDURE: PBR111 injection|DEVICE: PET scan|RADIATION: PBR111 dosimetry
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A First Time in Human Study to Assess GSK2336805 in Healthy Volunteers and Single Doses in Chronically Infected Hepatitis C Patients.
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: GSK2336805 10mg|DRUG: GSK2336805 30mg|DRUG: GSK2236805 100mg|DRUG: GSK2236805 200mg|DRUG: GSK2236805 10mg|DRUG: GSK2236805 dose to be determined up to 100mg|DRUG: GSK2236805 5mg|DRUG: GSK2236805 30mg|DRUG: GSK2236805 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Influence of Voluntary Isocapnic Hyperpnea on Blood Lactate Level and Rate of Perceived Exertion
Status: COMPLETED
Conditions: Blood Lactate Decrease
Interventions: BEHAVIORAL: Voluntary Isocapnic Hyperpnea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Biomarkers Predictive of Thymic Evolution and Therapeutic Response at 2 Years in Patients With a First Psychotic Episode
Status: NOT_YET_RECRUITING
Conditions: First-episode Psychosis
Interventions: OTHER: Recorded interview|OTHER: Clinical scales|BIOLOGICAL: Blood sample|OTHER: MRI scans of the brain
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetics, Pharmacodynamics and Safety of SHR4640 in Patients With Hepatic Impairment
Status: UNKNOWN
Conditions: Hepatic Impairment
Interventions: DRUG: SHR4640
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic and Pharmacodynamic Study of DZ-002 in Patients With Advanced Solid Malignancies or Lymphoma
Status: RECRUITING
Conditions: Solid Tumor|Lymphoma
Interventions: DRUG: DZ-002
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Revitalize Study in Older Adults at Risk for Alzheimer's Disease
Status: RECRUITING
Conditions: Cognitive Aging|Alzheimer Disease, Protection Against
Interventions: DEVICE: Active NIR-PBM|DEVICE: Sham NIR-PBM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Entrainment on Respiratory Stability and Cerebral Oxygenation in Preterm Infants
Status: RECRUITING
Conditions: Prematurity
Interventions: BEHAVIORAL: Music Therapy Entrainment with Ocean Disc Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Evacetrapib With Selected Statins in Healthy Chinese Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Evacetrapib|DRUG: Simvastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study in Patients With Chronic Obstructive Pulmonary Disease (FAIR)
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Foster® 100/6 µg/unit dose|DRUG: Symbicort® Turbohaler® 200/6 μg/actuation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Association of Trunk Stretching and Segmental Stabilization Exercises in Chronic Unspecific Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: SSASG|OTHER: SSPSG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glycemic Variations During the Menstrual Cycle in Women With Type 1 Diabetes
Status: RECRUITING
Conditions: Type1diabetes
Interventions: DEVICE: Continuous glucose monitoring|DRUG: Insulin|OTHER: Premenstrual symptoms|OTHER: Ovulation kits|DEVICE: Fitbit Inspire 2|OTHER: Keenoa|OTHER: Menstrual cycle
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Systemic Immune Checkpoint Blockade and Intraperitoneal Chemo-Immunotherapy in Recurrent Ovarian Cancer
Status: RECRUITING
Conditions: Ovarian Cancer Recurrent
Interventions: DRUG: Rintatolimod|DRUG: Pembrolizumab|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Examination of the Effects of Video-Based Games on Balance, Trunk Proprioception, Motivation and Quality of Life in Individuals With Cerebral Palsy
Status: COMPLETED
Conditions: CP (Cerebral Palsy)
Interventions: DEVICE: Microsoft Kinect 360|OTHER: Pediatric Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of an Infant Formula With Synbiotics in Infants Born Via Caesarean Section
Status: ACTIVE_NOT_RECRUITING
Conditions: Gut Microbiota
Interventions: OTHER: Intervention Group 1: Infant Formula with synbiotics|OTHER: Intervention Group 2: Infant Formula with prebiotics|OTHER: Control Group 1 and 2: Infant Formula without synbiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: HBV/HCV/HIV in Belgian Prisons
Status: COMPLETED
Conditions: Hepatitis C|Hepatitis B|HIV Infections
Interventions: OTHER: Prevalence of blood borne viral infections (HBV/HCV/HIV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Pharmacokinetic Study to Assess the Influence of P-glycoprotein Inhibition and Simultaneous CYP3A4 and P-glycoprotein Induction on E7080 Pharmacokinetics Following Single Dose Oral Administration of 24 mg E7080 to Healthy Volunteers
Status: COMPLETED
Conditions: P-glycoprotein|Healthy Volunteers
Interventions: DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Dose Study of BMS-582949 in Patients With Stable Rheumatoid Arthritis on the Methotrexate Background
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: BMS-582949 and Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomised Controlled Trial of Iodide Supplementation in Preterm Infants Follow-up at 2 Years
Status: COMPLETED
Conditions: Transient Hypothyroxinemia
Interventions: DRUG: sodium iodide|DRUG: Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prevention of Intraoperative Bleeding and Postoperative Swelling in Orthognathic Surgery Through the Use of Tranexamic Acid
Status: COMPLETED
Conditions: Intraoperative Bleeding|Postoperative Edema
Interventions: DRUG: Tranexamic Acid|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Decremental Esophageal Catheter Filling Volume Titration For Transpulmonary Pressure Measurement
Status: RECRUITING
Conditions: Pediatric Acute Respiratory Distress Syndrome (PARDS)|Acute Respiratory Failure|Acute Respiratory Distress Syndrome
Interventions: OTHER: Fast method|OTHER: Conventional method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Use of The Sentinel Device During Atrial Fibrillation Ablation
Status: WITHDRAWN
Conditions: Atrial Fibrillation
Interventions: DEVICE: Magnetic Resonance Imaging (MRI)|OTHER: Laboratory Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: TUDCA as a Therapy for Ulcerative Colitis (UC)
Status: UNKNOWN
Conditions: Ulcerative Colitis
Interventions: DRUG: Tauroursoursodeoxycholic acid, brand name Tudcabil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Bupivacaine Versus Bupivacaine-dexamethasone Infiltration for Postoperative Analgesia in Skin Graft Donor Sites
Status: COMPLETED
Conditions: Postoperative Pain Atskin Graft Site
Interventions: DRUG: Xylocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1a/1b Study of Aplitabart (IGM-8444) Alone or in Combination in Participants With Relapsed, Refractory, or Newly Diagnosed Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor|Colorectal Cancer|Non Hodgkin Lymphoma|Sarcoma|Chondrosarcoma|Small Lymphocytic Lymphoma|Chronic Lymphocytic Leukemia|Acute Myeloid Leukemia
Interventions: DRUG: Aplitabart (IGM-8444)|DRUG: FOLFIRI|DRUG: Bevacizumab (and approved biosimilars)|DRUG: Birinapant|DRUG: Venetoclax|DRUG: Gemcitabine|DRUG: Docetaxel|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breath Analysis in Patients With Suspected Sarcoidosis: The VOCs-IS Study
Status: COMPLETED
Conditions: Pulmonary Sarcoidosis
Interventions: OTHER: Breath Analysis|OTHER: Pulmonary Function Tests|OTHER: Blood sampling and storage for genetic analysis|OTHER: Blood sampling and storage of plasma for metabolomic analysis|OTHER: Bronchoalveolar lavage|OTHER: Sputum Culture|OTHER: Spirometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence Study of SAL001 and FORSTEO in Healthy Chinese Adults
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis
Interventions: BIOLOGICAL: SAL001|BIOLOGICAL: FORSTEO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Differential Diagnosis of Noisy Breathing Infants and Toddlers
Status: UNKNOWN
Conditions: Noisy Breathing Infants|Noist Breathing Toddlers|Wheezing|Rattling
Interventions: DEVICE: diagnosing noisy breathing in infants and toddlers
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessment of Efficacy and Safety in Relieving Opioid-induced Constipation in Patients With Cancer-related Pain
Status: TERMINATED
Conditions: Opioid-Induced Constipation
Interventions: DRUG: NKTR-118|DRUG: NKTR-118|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intrapleural Minocycline After Simple Aspiration for the Prevention of Primary Spontaneous Pneumothorax
Status: UNKNOWN
Conditions: Pneumothorax
Interventions: PROCEDURE: Simple aspiration with minocycline pleurodesis|PROCEDURE: simple aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesia During Pediatric Digestive Endoscopy: a Comparison of Two Protocols for Procedural Sedation
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PK, Safety and Tolerability of Single and Multiple Doses of Oxfendazole Tablets
Status: COMPLETED
Conditions: Filariasis
Interventions: DRUG: Oxfendazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemoradiation and Pembrolizumab Followed by Pembrolizumab and Lenvatinib Before Surgery for the Treatment of Non-metastatic Esophageal or Esophageal/Gastroesophageal Junction Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IIB Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8|Esophageal Adenocarcinoma|Esophageal Squamous Cell Carcinoma|Pathologic Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IA Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IB Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IC Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IIB Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8
Interventions: DRUG: Carboplatin|PROCEDURE: Endoscopic Biopsy|RADIATION: External Beam Radiation Therapy|DRUG: Lenvatinib Mesylate|DRUG: Paclitaxel|BIOLOGICAL: Pembrolizumab|PROCEDURE: Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MAgnetic Resonance Imaging-guided implanTation of Cardioverter DEFibrillators
Status: NOT_YET_RECRUITING
Conditions: Myocardial Infarction|Ventricular Tachycardia|Ventricular Fibrillation|Sudden Cardiac Death
Interventions: DEVICE: MRI screening|DEVICE: Implantable Loop Recorder|DEVICE: Implantable Cardioverter Defibrillator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Empowering Older Adults for Healthy Living and Better Dental Health
Status: RECRUITING
Conditions: Periodontal Diseases|Dental Caries
Interventions: BEHAVIORAL: Theory-derived intervention|BEHAVIORAL: Conventional health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Impact of Forest Baths on Emotional Well-being in People With Sub-clinical Symptomatology of Anxiety and Depression
Status: RECRUITING
Conditions: Psychological Well-being
Interventions: BEHAVIORAL: Intervention group A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The 4th Trimester Initiative: The Impact of Parental Support on Pregnant Trainee Wellbeing
Status: RECRUITING
Conditions: Pregnancy Related|Burnout, Professional|Wellness, Psychological
Interventions: DEVICE: Snoo smart bassinet|DEVICE: Willow wearable breast pump|BEHAVIORAL: Maven Clinic on-demand perinatal consultation|BEHAVIORAL: Faculty mentor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety Study Of Avastin And Pelvic Radiation In Women With Recurrent Gynecological Cancers
Status: COMPLETED
Conditions: Cervical Cancer|Endometrial Cancer|Ovarian Cancer|Vaginal Cancer|Carcinoma of the Vulva
Interventions: DRUG: Avastin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Seaweed and Early Breast Cancer: A Randomized Trial
Status: COMPLETED
Conditions: Seaweed Associated Changes in Healthy Subjects
Interventions: OTHER: Seaweed|OTHER: Placebo|OTHER: Placebo2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP)
Status: COMPLETED
Conditions: HTLV I Associated Myelopathy
Interventions: DRUG: ciclosporin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Assisted Delivery of Minoxidil in Androgenetic Alopecia
Status: WITHDRAWN
Conditions: Male Pattern Hair Loss|Androgenetic Alopecia|Male Pattern Baldness
Interventions: DRUG: Post-Laser Minoxidil 2%|DRUG: At-Home Minoxidil 5%|DEVICE: Laser|DRUG: Post-laser 5mg minoxidil|DRUG: Post-laser 10mg minoxidil|DRUG: Post-laser 20mg minoxidil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Nicotine Inhaler and/or Bupropion in Helping People to Stop Smoking and Prevent the Recurrence of Smoking
Status: COMPLETED
Conditions: Lung Cancer
Interventions: OTHER: placebo|DRUG: bupropion hydrochloride|DRUG: nicotine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Antigravity Treadmill in Knee Osteoarthritis (AGTreadmill)
Status: NOT_YET_RECRUITING
Conditions: Knee Osteoarthritis
Interventions: OTHER: antigravity treadmill|OTHER: physical therapy exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Tolerability, Safety and Efficacy of Enteric-coated Mycophenolate Sodium, After Equimolar Conversion From Mycophenolate Mofetil (MMF), in Patients With Stable Renal Transplant Receiving Tacrolimus
Status: COMPLETED
Conditions: Prevention of Acute Rejection After Kidney Transplantation
Interventions: DRUG: Enteric-coated mycophenolate sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Use of Vasopressin in Patients at High Risk of Acute Kidney Injury Admitted to the ICU
Status: NOT_YET_RECRUITING
Conditions: Critical Illness
Interventions: DRUG: Vasopressin|OTHER: 0,9% saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acute Hemodynamic Response to Carvedilol in Predicting Survival in Acute on Chronic Liver Failure Patients - A Pilot Study.
Status: RECRUITING
Conditions: Acute on Chronic Liver Failure
Interventions: DRUG: Carvedilol 12.5 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Carvedilol on Exercise Performance in Fontan Patients
Status: COMPLETED
Conditions: Single Ventricle|Fontan
Interventions: DRUG: Carvedilol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Induced Moderate Hypothermia on ARDS Patients Under Venovenous ExtraCorporeal Membrane Oxygenation
Status: UNKNOWN
Conditions: ARDS, Human|Extracorporeal Membrane Oxygenation Complication|Hypothermia
Interventions: DEVICE: Moderate Hypothermia|DEVICE: Normothermia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Controlled Human Malaria Infection Transmission Model - Phase A
Status: SUSPENDED
Conditions: Malaria,Falciparum
Interventions: BIOLOGICAL: PfSPZ Challenge|DRUG: Sulfadoxine-Pyrimethamine|DRUG: Piperaquine|DRUG: Artemether lumefantrine|DRUG: Primaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Saliva and Plasma Exosomes for Oral Leukoplakia Malignant Transformation Diagnosis and Oral Cancer Prognosis Monitoring
Status: COMPLETED
Conditions: Oral Leukoplakia|Oral Cancer
Interventions: OTHER: Detect the expression level of miR-185 in salivary and plasma exosomes.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Low Field Magnetic Stimulation (LFMS) in Mood Disorders: 6 Treatments
Status: SUSPENDED
Conditions: Bipolar Depression|Unipolar Depression
Interventions: DEVICE: Low Field Magnetic Stimulation Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment and Evaluation of Pharmacokinetic Profile of E004 in Healthy Adults
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: Arm T Epinephrine Inhalation Aerosol HFA, 125 mcg, 1 inhalation|DRUG: Arm C-Epinephrine Inhalation Aerosol CFC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Control After Total Knee Arthroplasty: Benefit In Adding Single Shot Adductor Canal Block to Existing Pain Regimen Protocol?
Status: COMPLETED
Conditions: Pain
Interventions: PROCEDURE: Adductor Canal Block|PROCEDURE: Periarticular Injection|DRUG: Ropivacaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Intraparenchymal Therapy as Adjunct Therapy in Patients With Recurrent, Resectable Glioblastoma Multiforme.
Status: TERMINATED
Conditions: Glioma
Interventions: PROCEDURE: CM-BC2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral ONC201 in Recurrent GBM, H3 K27M Glioma, and Midline Glioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma|Diffuse Midline Glioma|H3 K27M Glioma|Thalamic Glioma|Infratentorial Glioma|Basal Ganglia Glioma
Interventions: DRUG: ONC201
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Simvastatin on the Prognosis of Primary Primary Sclerosing Cholangitis (PSC)
Status: RECRUITING
Conditions: Primary Sclerosing Cholangitis
Interventions: DRUG: Simvastatin 40mg|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spatial Hearing Perception in Bilateral Cochlear Implant Children
Status: COMPLETED
Conditions: Cochlear Impant Children
Interventions: OTHER: behavioral exploration of spatial hearing performances|OTHER: The Speech, Spatial and Qualities of Hearing Scale (SSQ) questionnaire (for cochlear implant children and their parents)|OTHER: The Speech, Spatial and Qualities of Hearing Scale (SSQ) questionnaire (for parents of CI children)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intra-gallbladder or Systemic Indocyanide Green Injection Facilitate Cholecystectomy.
Status: UNKNOWN
Conditions: Fluorenscent Image Guided Surgery|Indocyanide Green
Interventions: PROCEDURE: ICG GB|PROCEDURE: ICG IV|PROCEDURE: LC conventional|PROCEDURE: LC conventional and IOC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy and Mechanism of High Definition tDCS Based on dmPFC in the Intervention of Chronic Insomnia
Status: RECRUITING
Conditions: Chronic Insomnia|Transcranial Direct Current Stimulation
Interventions: DEVICE: transcranial direct current stimulation|DEVICE: sham transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study in Healthy Volunteers, to Evaluate the Safety, Efficacy and Dose Responses of SB-751689 (Ronacaleret)
Status: COMPLETED
Conditions: Transplantation, Stem Cell
Interventions: DRUG: Ronacaleret 100 mg|DRUG: Ronacaleret 400 mg|DRUG: Plerixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imaging Tau in Alzheimer's Disease and Normal Aging
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: 18F-THK-5351|PROCEDURE: Lumbar Puncture (optional)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial of Repeated Analgesia With Kangaroo Care - 18 Month Follow-up
Status: UNKNOWN
Conditions: Pain|Development
Interventions: PROCEDURE: Vaccinations at 2, 6, 12 and 18 month|BEHAVIORAL: Neurodevelopment assessment at 18 corrected age
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Out Of-plane Technique Against In-plane for Caudal Block
Status: UNKNOWN
Conditions: Ultrasound Imaging|Caudal Block|Hypospadias
Interventions: DEVICE: Out of-Plane Technique and In-Plane on
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: This Was an Open-label, Single-arm Extension Study (CFTY720D2306E1) to a Double-blind, Randomized Multicenter, Placebo-controlled, Parallel-group Core Study (CFTY720D2306) in PPMS.
Status: TERMINATED
Conditions: Primary Progressive Multiple Sclerosis
Interventions: DRUG: FTY720|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inositol in Preventing Colorectal Cancer in Patients With Colitis-Associated Dysplasia
Status: TERMINATED
Conditions: Colon Carcinoma|Dysplasia in Crohn Disease|Low Grade Dysplasia in Ulcerative Colitis|Rectal Carcinoma
Interventions: DRUG: Inositol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study on Incidence of Diabetic Ketoacidosis Among Participants With Type 2 Diabetes Mellitus Treated With Sodium-glucose Co-transporter 2 (SGLT2) Inhibitors or Other Antihyperglycemic Agents
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: No Intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Inserting Exercises During Physical Education Classes on Anxiety and Depression Symptoms in Adolescents
Status: UNKNOWN
Conditions: Depressive Symptoms|Anxiety Symptoms
Interventions: OTHER: Diaphragmatic breathing exercises|OTHER: Cardiorespiratory and strength exercise|OTHER: Cooperative sports activities group|OTHER: Traditional physical education class
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Stroke Prevention In Ischemic Stroke With Covert Atrial Fibrillation
Status: NOT_YET_RECRUITING
Conditions: Stroke|Ischemic Stroke|Cerebral Infarction|Atrial Fibrillation
Interventions: DRUG: Apixaban|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Video Stylet vs. Flexible Bronchoscopy for C-Spine
Status: RECRUITING
Conditions: Intubation;Difficult|Intubation Complication
Interventions: DEVICE: C-MAC VS|DEVICE: Flexible Bronchoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Proprietary Cherry Juice Blend in Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: OTHER: proprietary cherry juice blend (food)|OTHER: control juice (kool aid blend)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lay Health Worker Expanded Intervention in Community Oncology Practices
Status: ACTIVE_NOT_RECRUITING
Conditions: End of Life|Cancer
Interventions: BEHAVIORAL: Program participants|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH