pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Clinical Trial of CSL's 2009 H1N1 Influenza Vaccine (CSL425) in Healthy Adults
Status: COMPLETED
Conditions: Influenza Caused by the Novel Influenza A (H1N1) Virus
Interventions: BIOLOGICAL: CSL425|BIOLOGICAL: CSL425
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Hemodynamic Ramp Test-Guided HVAD RPM and Medication Adjustments on Exercise Tolerance and Quality of Life
Status: COMPLETED
Conditions: Continous Flow Left Ventricular Device
Interventions: PROCEDURE: Echo Guided Testing|PROCEDURE: Hemodynamic-Echo Ramp Testing -
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Assess the Feasibility and Tolerability of the AccuFlow Perfusion Sensor for Intrapartum Hemorrhage
Status: COMPLETED
Conditions: Hemorrhage, Postpartum|Hemorrhage|Vasoconstriction
Interventions: DEVICE: AccuFlow sensor|OTHER: Survey
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Investigate Safety, Tolerability, Pharmacokinetics and Cardiac Function After Repeat Doses of SB-649868 in Healthy-volunteers
Status: COMPLETED
Conditions: Sleep Disorders
Interventions: DRUG: SB-649868
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Police-Mental Health Linkage System
Status: SUSPENDED
Conditions: Mental Disorders, Severe|Schizophrenia and Related Disorders|Bipolar Disorder|Depressive Disorder
Interventions: OTHER: The Police-Mental Health Linkage System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Repurposing of Chlorpromazine in Covid-19 Treatment
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: CHLORPROMAZINE (CPZ)|COMBINATION_PRODUCT: Standard of Care (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Study With Unlabeled Dose and 14C-labeled Microdose of PF-06700841 in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Male Subjects
Interventions: DRUG: Oral PF-06700841 containing 14C microtracer|DRUG: Oral unlabeled PF-06700841|DRUG: IV 14C-labeled PF-06700841
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Quadratus Lumborum Block and Epidural Analgesia Following Kidney Transplant Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Continuous Epidural analgesia|PROCEDURE: Bilateral Quadratus Lumborum block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tocilizumab and Hemophagocytic Lymphohistiocytosis (HLH)
Status: WITHDRAWN
Conditions: Hemophagocytic Lymphohistiocytosis
Interventions: DRUG: tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Trial of the Combination of Aliskiren / Hydrochlorothiazide (HCTZ)(300/12.5 mg and 300/25 mg) Compared to Aliskiren 300 mg in Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Aliskiren/HCTZ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Fractional Flow Reserve Derived From Computed Tomography Coronary Angiography in the Assessment and Management of Stable Chest Pain
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: FFRct|DIAGNOSTIC_TEST: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Interest of Intrathecal Chemotherapy With Liposomal Cytarabine (DepoCyte®) in Meningeal Metastasis of Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Leptomeningeal Metastases
Interventions: DRUG: Liposomal Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-Defibrillator (ICD) Implantation to Prevent Tachyarrhythmias Following Acute Myocardial Infarction (PROTECT-ICD)
Status: RECRUITING
Conditions: Sudden Cardiac Death
Interventions: PROCEDURE: Electrophysiology study (EPS)|OTHER: Standard Care|PROCEDURE: Cardiac Magnetic Resonance (CMR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: After Caesarean Section Oxitocin Breast Massage Anthropometric Characteristics of the Newborn
Status: COMPLETED
Conditions: Breastfeeding, Exclusive|Breastfeeding
Interventions: BEHAVIORAL: Oxytocin massage|BEHAVIORAL: and Breast massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Design Validation Hemodynamic Study of New Kendall SCD SmartFlow Compression System
Status: RECRUITING
Conditions: Hemodynamics
Interventions: DEVICE: Intermittent Pneumatic Compression (IPC)(Kendall SCD SmartFlow™ compression system with Cardinal Health Element compression sleeves)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Safety and Efficacy of Stribild Versus Ritonavir-Boosted Atazanavir Plus Truvada in Human Immunodeficiency Virus, Type 1 (HIV-1) Infected, Antiretroviral Treatment-Naive Adults
Status: COMPLETED
Conditions: HIV|HIV Infections
Interventions: DRUG: Stribild|DRUG: ATV|DRUG: Ritonavir|DRUG: FTC/TDF|DRUG: Stribild Placebo|DRUG: ATV Placebo|DRUG: RTV Placebo|DRUG: FTC/TDF Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short Versus Long Antibiotic Course for Pleural Infection Management (SLIM Trial)
Status: COMPLETED
Conditions: Pleural Infection
Interventions: OTHER: Short course (2-3 weeks) of antibiotics|OTHER: Standard (long course) of antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Scalable Nutrition Adherence Intervention
Status: RECRUITING
Conditions: Alzheimer Disease|Mild Cognitive Impairment
Interventions: BEHAVIORAL: Modified Mediterranean Ketogenic Nutrition Adherence Program|BEHAVIORAL: Mediterranean Nutrition Adherence Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid Eye Movement Restoration and Enhancement for Sleep-deprived Trauma-adaptation
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DEVICE: Transcranial electrical stimulation with Temporal Interference (TES-TI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neurophysiological Effects of Transcutaneous Electrical Nerve Stimulation in Persons With MS
Status: NOT_YET_RECRUITING
Conditions: Fatigue|Walking, Difficulty|Multiple Sclerosis
Interventions: DEVICE: Transcutaneous Electrical Nerve Stimulation|BEHAVIORAL: Movement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: MS 209 Plus Docetaxel in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: docetaxel|DRUG: dofequidar fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Preference-based Comparative Study on Definitive Radiotherapy of Prostate Cancer With Protons
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: Radiotherapy with protons|RADIATION: Radiotherapy with photons
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MILES-3: Cisplatin in Combination With Gemcitabine for Elderly Patients With Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer Metastatic|Non-small Cell Lung Cancer Stage IIIB
Interventions: DRUG: Gemcitabine|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The WILLOW Study With M5049 in SLE and CLE (SCLE and/or DLE) (WILLOW)
Status: ACTIVE_NOT_RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Enpatoran low dose|DRUG: Enpatoran medium dose|DRUG: Enpatoran high dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Learning Teams for Reflective Adaptation for Diabetes and Depression
Status: COMPLETED
Conditions: Type 2 Diabetes|Hyperlipidemia|Hypertension|Depression
Interventions: BEHAVIORAL: Standard CQI intervention|BEHAVIORAL: Chronic Care Improvement (CCI) Intervention|BEHAVIORAL: Self-directed practice comparison
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Adhear Bone Conduction System
Status: TERMINATED
Conditions: Hearing Loss, Conductive|Hearing Loss, Unilateral
Interventions: DEVICE: Adhear Bone Conduction System|DEVICE: Bone anchored hearing aid (BAHA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Self Controlled Clinical Study of Hemostatic Efficacy of the HemCon Dental Dressing
Status: COMPLETED
Conditions: Tooth Extractions
Interventions: DEVICE: Hemcon Dental Dressing|DEVICE: Gauze with Pressure and/or Gelfoam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Brief Surf the Urge Intervention
Status: COMPLETED
Conditions: Substance Use|Deliberate Self-harm|Trichotillomania|Aggression|Stealing|Eating Pathology|Gambling
Interventions: BEHAVIORAL: Surf the Urge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Oxycodone Hydrochloride on CRBD After TURBT Under General Anesthesia
Status: NOT_YET_RECRUITING
Conditions: Effect of Drug|Adverse Effect of Opioids
Interventions: DRUG: Fentanyl group|DRUG: Oxycodone Hydrochloride group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TSEB and Brentuximab for Treatment of Mycosis Fungoides & Sezary Syndrome
Status: COMPLETED
Conditions: Mycosis Fungoides|Sézary Syndrome
Interventions: RADIATION: TSEB Therapy|DRUG: Brentuximab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study for the Treatment of Painful Diabetic Neuropathy
Status: COMPLETED
Conditions: Painful Diabetic Neuropathies
Interventions: BIOLOGICAL: Low Dose: 16 mg Engensis (VM202)|BIOLOGICAL: High Dose: 32 mg Engensis (VM202)|OTHER: Control- Placebo (normal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Retaining Cognition While Avoiding Late-Life Depression
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Problem Solving Therapy|BEHAVIORAL: Problem Solving Therapy + Exercise|OTHER: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MIRM Versus PIRT in Athletes With Glenohumeral Internal Rotation Deficit
Status: COMPLETED
Conditions: Glenohumeral Internal Rotation Deficit|Rotator Cuff Impingement|Internal Rotation Contracture-shoulder
Interventions: OTHER: Mulligan Internal Rotation Mobilization|OTHER: Post Isometric Relaxation Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: REVOLUTION (WFCC-133) - Treatment of Paroxysmal Atrial Fibrillation
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: nMARQ™ System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thiazolidinedione (TZD) on the Diabetic Retinopathy and Nephropathy
Status: UNKNOWN
Conditions: Diabetes
Interventions: DRUG: Actos (Pioglitazone)|DRUG: Acarbose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treating the Symptoms of Vertigo in a Real-world Setting Using the OtoBand
Status: COMPLETED
Conditions: Vertigo|BPPV|Meniere Disease|Labrynthitis|Vestibular Disorder|Vestibular Migraine|Benign Paroxysmal Positional Vertigo|Ménière's Vertigo
Interventions: DEVICE: Otoband Experimental|DEVICE: Otoband Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study in Patients With Advanced Non-Small Cell Lung Cancer Treated With Pemetrexed and Carboplatin Plus or Minus Sorafenib
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: pemetrexed, carboplatin, sorafenib|DRUG: pemetrexed, carboplatin, placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Examining the Combination of Revlimid (Lenalidomide)and Vidaza (Azacitidine) for Relapsed/Refractory CLL and SLL
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia(CLL)|Small Lymphocytic Lymphoma
Interventions: DRUG: Revlimid|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study of Nimotuzumab Plus Concurrent Chemoradiotherapy in Loco-regional Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Prosthesis Survival
Interventions: DRUG: Nimotuzumab|RADIATION: radiotherapy|DRUG: chemoradiotherapy Paclitaxel|DRUG: chemoradiotherapy Cisplatin|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Renal Uptake of Fatty Acids (FFA) in Patients With Idiopathic Uric Acid Nephrolithiasis (IUAN)
Status: WITHDRAWN
Conditions: Uric Acid Nephrolithiasis
Interventions: OTHER: 123I-BMIPP|OTHER: 99mTc-MAG3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immunogenicity and Safety of COVID-19 Vaccine in Population Aged 18 Years and Above
Status: WITHDRAWN
Conditions: COVID-19
Interventions: BIOLOGICAL: One dose group|BIOLOGICAL: Two doses group|BIOLOGICAL: Aged 18-59 years|BIOLOGICAL: Aged 60 years old and above
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity of 23-valent Pneumococcal Polysaccharide Vaccine in 2 to 70 Years Old Healthy People in China
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: vaccine made by Beijing Minhai Biotechnology Co., Ltd|BIOLOGICAL: vaccine made by Chengdu Institute of Biological Products
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Danggui Buxue Tang on Blood Biochemical Parameters in Male Recreational Runners
Status: COMPLETED
Conditions: Sports Anemia|Inflammation|Oxidative Stress|Iron Deficiency|Hemolysis|Fatigue
Interventions: DIETARY_SUPPLEMENT: Danggui Buxue Tang|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Efficacy & Safety of Intravenous (IV) Acetaminophen Versus Placebo for the Treatment of Postop Pain
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: IV Placebo|DRUG: IV Placebo|DRUG: IV Acetaminophen|DRUG: IV Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant and Adjuvant Lenvatinib in HCC Patients Treated by Percutaneous Ablative
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Lenvatinib Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thin Film Spectacle Coatings to Reduce Light Sensitivity and Headaches in Child and Adolescent Patients With Migraine
Status: TERMINATED
Conditions: Migraine Disorders|Photophobia
Interventions: DEVICE: Investigational Coating
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SILtuximab in Viral ARds (SILVAR) Study
Status: TERMINATED
Conditions: Acute Respiratory Distress Syndrome|Lung Diseases|Pneumonia|Respiratory Tract Infections|Respiratory Tract Disease
Interventions: DRUG: Siltuximab|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Living Memory Home-4-Dementia Care Pairs
Status: NOT_YET_RECRUITING
Conditions: Dyadic Family Caregiver-person With Dementia Online Intervention
Interventions: BEHAVIORAL: LMH-4-DCP|BEHAVIORAL: LMH-4-DCP access without reminiscence activities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Myocardial Protection With Adenosine Preconditioning
Status: COMPLETED
Conditions: Heart Defects, Congenital|Cardiac Surgical Procedures|Myocardial Reperfusion Injury|Adenosine
Interventions: DRUG: adenosine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pubertal Induction in Individuals With Hypogonadism
Status: UNKNOWN
Conditions: Primary Amenorrhoea|Hypothalamic Amenorrhoea|Hypogonadotrophic Hypogonadism|Hypopituitarism|Turner's Syndrome|Primary Ovarian Insufficiency
Interventions: DRUG: Routine transdermal oestrogen patch
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Lymphoblastic Lymphoma
Interventions: DRUG: Rituximab|DRUG: Nelarabine|DRUG: PEG-Asparaginase|PROCEDURE: Cranial irradiation|DRUG: Imatinib|DRUG: Idarubicin|DRUG: Dexamethasone|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Vincristine|DRUG: Mercaptopurine|DRUG: VP16|DRUG: Daunorubicin (DNR)|DRUG: Methotrexate|PROCEDURE: Stem cell transplantation|DRUG: Cytarabine|DRUG: Vindesine|DRUG: Adriamycin|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on the Safety and Effectiveness of Temozolomide for Neoadjuvant Treatment of PPGL
Status: RECRUITING
Conditions: Pheochromocytoma|Paraganglioma
Interventions: DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer (VIKTORIA-1)
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Gedatolisib|DRUG: Palbociclib|DRUG: Fulvestrant|DRUG: Alpelisib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fibrinogen to Albumin Ratio and C-reactive Protein to Albumin Ratio in Juvenile Idiopathic Arthritis
Status: NOT_YET_RECRUITING
Conditions: Juvenile Idiopathic Arthritis
Interventions: DIAGNOSTIC_TEST: fibrinogen to albumin ratio (AFR) and C-reactive protein to albumin ratio (CAR)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Prochymal® for the Salvage of Treatment-Refractory Acute GVHD Patients
Status: COMPLETED
Conditions: Graft Versus Host Disease
Interventions: DRUG: Prochymal®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanism of PERK - eIF2a Pathways in Intestinal Mucosal Barrier of IBS-D and the Role "Metabolism Ingredients" of Tongxieyaofang
Status: UNKNOWN
Conditions: IBS (Irritable Bowel Syndrome)
Interventions: DRUG: Tongxieyaofang(granule)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010)
Status: UNKNOWN
Conditions: Dupuytren Contracture
Interventions: DEVICE: Intervention - ESWT Storz Duolith high energy|DEVICE: CONTROL SHAM-ESWT Storz Duolith [0.01mJ/mm2]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Volatile Anesthetics Sevoflurane and Desflurane on Liver, Renal and Cardiovascular Systems During Liver Surgery
Status: UNKNOWN
Conditions: Apoptosis|Liver Surgery
Interventions: PROCEDURE: Liver surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Olaparib Maintenance Monotherapy in Patients With BRCA Mutated Ovarian Cancer Following First Line Platinum Based Chemotherapy.
Status: ACTIVE_NOT_RECRUITING
Conditions: Newly Diagnosed|Advanced Ovarian Cancer|FIGO Stage III-IV|BRCA Mutation|Complete Response|Partial Response|First Line Platinum Chemotherapy
Interventions: DRUG: Olaparib 300mg tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Community-delivered Integrated Malaria Elimination (CIME) Model in Myanmar
Status: UNKNOWN
Conditions: Malaria
Interventions: OTHER: Community-delivered Integrated Malaria Elimination (CIME) intervention model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Virtual Reality-Mediated Rehabilitation in Ischemic Stroke Patients
Status: COMPLETED
Conditions: Hemiplegia
Interventions: DEVICE: Virtual Reality Mediated Upper Extremity Rehabilitation (SensoRehab®)|OTHER: conventional rehabilitation program|BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Outcomes Between Biceps Tenotomy and Tenodesis in the Treatment of the Long Head of the Biceps Pathology
Status: COMPLETED
Conditions: Chronic Refractive Bicipital Pain
Interventions: PROCEDURE: Biceps tenotomy|PROCEDURE: Biceps tenodesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 24-Month Study to Evaluate the Efficacy and Safety of Elenbecestat (E2609) in Participants With Early Alzheimer's Disease
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: Elenbecestat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Blinatumomab in Patients With NGS-MRD Relapsed B-ALL After Autologous/Allogeneic Transplantation
Status: NOT_YET_RECRUITING
Conditions: B-ALL
Interventions: DRUG: Blinatumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Acute Effects of Dynamic Stretching, Plyometrics, and Loading on Achilles Tendon Properties and Performance Outcomes
Status: COMPLETED
Conditions: Tendon Injuries
Interventions: OTHER: AAROM|OTHER: Slow Load|OTHER: Plyometric
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Wrist Denervation vs Exercise in Wrist Osteoarthritis
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis Wrist
Interventions: BEHAVIORAL: Self-managed exercise therapy program|PROCEDURE: Partial wrist denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Oral Synbiotic Formula in Reducing Adenoma Recurrence and Colorectal Neoplasia-related Bacterial Gene Markers
Status: RECRUITING
Conditions: Colorectal Neoplasms|Colorectal Adenoma|Colorectal Cancer
Interventions: OTHER: SMT04 formula|OTHER: Active placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate GlaxoSmithKline (GSK) Biologicals' MenC-TT Vaccine and Hib-MenC-TT Vaccine in Infants
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: MenC-TT|BIOLOGICAL: Hib-MenC-TT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mechanical Bowel Preparation With or Without Oral Antibiotics for Colorectal Cancer Surgery
Status: UNKNOWN
Conditions: Antibiotic|Bowel Cancer|Colorectal Cancer|Surgical Site Infection
Interventions: OTHER: Bowel Preparation plus antibiotics|OTHER: Bowel Preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Determine the Fasting Bioequivalence of Reformulated OXY Tablets and Original OxyContin® (OXY) Tablets
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Reformulated OXY (oxycodone HCl)|DRUG: Original OxyContin® (OXY) (oxycodone HCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: This Record Contains Information About the Mepolizumab Compassionate Use (CU) Product Activities: 104317: CU and Long-Term Access Study of Mepolizumab in HES. 201956:A Long-term Access Programme for Subjects With Severe Asthma 112562: Expanded Access for Patients With Hypereosinophilic
Status: NO_LONGER_AVAILABLE
Conditions: Hypereosinophilic Syndrome
Interventions: DRUG: Mepolizumab
Study Type: EXPANDED_ACCESS
Clinical trial: Cancers Treated With Combination of Antrodia Cinnamomea and Chemotherapy
Status: UNKNOWN
Conditions: Neoplasm|Functional Gastrointestinal Disorder
Interventions: DIETARY_SUPPLEMENT: AC-Can|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Program evaLuating the Autoimmune Disease iNvEstigational Drug cT-p13 in RA Patients(PLANETRA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tick-Borne Encephalitis (TBE) Seropersistence After First Booster and Response to a Second Booster in Children, Adolescents and Young Adults (Follow-Up to Study 700401)
Status: COMPLETED
Conditions: Encephalitis, Tick-Borne
Interventions: BIOLOGICAL: FSME-IMMUN 0.25 mL Junior (1.2 µg TBE antigen/0.25 mL) or FSME-IMMUN 0.5 mL (2.4µg TBE antigen/0.5 mL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Epoetin Alfa in Treating Anemia in Patients Undergoing Chemotherapy for Multiple Myeloma
Status: COMPLETED
Conditions: Anemia|Multiple Myeloma|Plasma Cell Neoplasm
Interventions: BIOLOGICAL: epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Explore Morbimortality in Patients Dialyzed With the Theranova HDx in Comparison to On-Line-Hemodiafiltration
Status: UNKNOWN
Conditions: Chronic Kidney Disease Requiring Chronic Dialysis
Interventions: DEVICE: A synthetic high-flux dialyzer will be used for OL-HDF.|DEVICE: A medium cut-off dialyzer will be used for HDx.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of 3 Different Protocols for Preventing Premature Ovulation in Ovarian Stimulation Cycles
Status: RECRUITING
Conditions: Infertility
Interventions: DRUG: Gonadotropin releasing hormone antagonist (Cetrotide)|DRUG: Medroxyprogesterone Acetate (Tarlusal)|DRUG: Dydrogesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors
Status: UNKNOWN
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: carboplatin|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: methotrexate|DRUG: temozolomide|DRUG: thiotepa|DRUG: vincristine sulfate|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: autologous hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Correlation of Measurements From Mespere Venus 1000 System & Echocardiography to Estimate Right Atrial Pressure
Status: COMPLETED
Conditions: Patients Referred to St. Michael's Hospital Echocardiography Lab
Interventions: DEVICE: Mespere Venus 1000 System|DEVICE: Echocardiography machine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical and Histological Evaluation of the 755nm Alexandrite Laser With Handpiece for the Treatment of Scars
Status: COMPLETED
Conditions: Scars
Interventions: DEVICE: 755nm Alexandrite Laser with handpiece 2|DEVICE: 755nm Alexandrite Laser with handpiece 1|DEVICE: 755nm Alexandrite Laser with handpiece 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Tabata vs Plyometric Training on Range of Motion, Agility and Vertical Jump in Taekwondo Players
Status: RECRUITING
Conditions: High-Intensity Interval Training|Plyometric Exercise|Martial Arts
Interventions: OTHER: tabata training|OTHER: plyometric training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of SA09012 in Asthma
Status: COMPLETED
Conditions: Mild to Moderate Bronchial Asthma
Interventions: DRUG: SA09012 Low dose|DRUG: SA09012 High dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of PlayStation Distraction in the Dental Setting
Status: COMPLETED
Conditions: Global Behaviour Measure
Interventions: BEHAVIORAL: Patients will play a video game with Rimax® multimedia eyeglasses that occlude the environment partially during the second treatment visit.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Evaluate Benefit of ProbioSatys™ on Weight Reduction in Overweight Subjects
Status: COMPLETED
Conditions: Overweight|Weight Loss
Interventions: DIETARY_SUPPLEMENT: ProbioSatys™|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pertuzumab in Combination With Trastuzumab and Chemotherapy in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Gastroesophageal Junction or Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: 5-Fluorouracil|DRUG: Capecitabine|DRUG: Cisplatin|DRUG: Pertuzumab|DRUG: Placebo|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GEMOX-HAIC Plus GEM-SYS in Combination With Lenvatinib and PD-1 Inhibitor for Large Unresectable ICC
Status: RECRUITING
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: DRUG: Gemcitabine-Oxaliplatin Regimen
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ipilimumab and Nivolumab as Adjuvant Treatment of Mucosal Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Mucosal Melanoma
Interventions: DRUG: Ipilimumab|DRUG: Nivolumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhanced External Counter Pulsation on Afterload Mismatch Rate in Post-TEER (PAMPER)
Status: NOT_YET_RECRUITING
Conditions: Mitral Regurgitation
Interventions: DEVICE: EECP|DEVICE: Sham-EECP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Assessment of Patients With Chronic Obstructive Pulmonary Disease (COPD) and/or Chronic Heart Failure (CHF)
Status: COMPLETED
Conditions: COPD|Heart Failure, Congestive
Interventions: PROCEDURE: Lung function testing, echocardiography, blood sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Nurse Led Patient Management Programme to Improve Outcomes in Gout
Status: COMPLETED
Conditions: Gout|Arthritis|Crystal Arthropathy
Interventions: OTHER: nurse led plus standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Atorvastatin to Reduce Inflammation After Tuberculosis Treatment Completion
Status: RECRUITING
Conditions: Tuberculosis, Pulmonary
Interventions: DRUG: Atorvastatin 40mg|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IVIg Therapy for Patients With Idiopathic Cardiomyopathy and Endomyocardial Biopsy Proven High PVB19 Viral Load
Status: UNKNOWN
Conditions: Heart Failure
Interventions: DRUG: Intravenous immunoglobulin therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Absorption, Metabolism, and Excretion of [14C]-SKI-O-703 Following a Single Oral Dose in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: .[14C]-SKI-O-703
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Memantine on Brain Structure and Chemistry in Alzheimer's Disease Patients
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Memantine|DRUG: Placebo pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Body Volume Regulation in Pulmonary Arterial Hypertension With Right Ventricular Failure
Status: WITHDRAWN
Conditions: Right Heart Failure|Pulmonary Hypertension
Interventions: DRUG: Spironolactone and conivaptan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Platelet Rich Plasma on Partial Thickness Rotator Cuff Tears: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Rotator Cuff Injuries
Interventions: BIOLOGICAL: Platelet Rich Plasma (PRP)|DRUG: Corticosteroid (CS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Of A Cognitive Behavioral Therapy To Decrease Threat Appraisal In HIV Participants Initiating Antiretroviral
Status: UNKNOWN
Conditions: HIV|Threat Appraisal
Interventions: OTHER: Usual Care (UC)|BEHAVIORAL: Cognitive Behavioral Therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Iron Absorption From GDS Capsules II
Status: COMPLETED
Conditions: Iron Deficiency
Interventions: DIETARY_SUPPLEMENT: GDS capsule with meal|DIETARY_SUPPLEMENT: Ferrous sulfate with meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Diuretic Use in Hemodialysis Patients With Residual Renal Function
Status: SUSPENDED
Conditions: End Stage Renal Disease on Dialysis
Interventions: DRUG: Furosemide|DRUG: Chlorthalidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deferiprone to Delay Dementia (The 3D Study)
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Prodromal Alzheimer's Disease|Mild Alzheimer's Disease
Interventions: DRUG: Deferiprone 600mg delayed release tablets|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Oxygen Therapy as Adjunctive Treatment of Chronic Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetes|Foot Ulcer|Healing
Interventions: DEVICE: hyperbaric air|DEVICE: HBOT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brain Outcomes With Lifestyle Change in Down Syndrome
Status: NOT_YET_RECRUITING
Conditions: Down Syndrome|Alzheimer Disease|Obesity
Interventions: BEHAVIORAL: Diet|BEHAVIORAL: Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial of Novel OPV2 Vaccine
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: novel oral polio type 2 vaccine (nOPV2)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Guided Eight-week Online Acceptance and Commitment Therapy for Distressed Family Caregivers of People With Dementia
Status: COMPLETED
Conditions: Psychological Distress
Interventions: BEHAVIORAL: acceptance and commitment therapy (ACT)|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Clinical Trial of Oral Magnesium Supplementation in Pregnancy
Status: COMPLETED
Conditions: Magnesium Deficiency|Preterm Birth|Extreme Immaturity
Interventions: DRUG: Magnesium citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: REPOSE Study: Reducing Delirium by Enhancing Postoperative Sleep With Suvorexant
Status: RECRUITING
Conditions: Delirium in Old Age
Interventions: DRUG: Suvorexant 20 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture Trial for Post Anaesthetic Recovery and Postoperative Pain
Status: COMPLETED
Conditions: Laparoscopic Surgery of Uterus, Adnex or Ovaries|Postoperative Pain
Interventions: OTHER: Acupuncture Regimen|OTHER: Acupressure Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Kinesiotaping on Pain, Edema and Functionality After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Arthroplasty|Pain|Edema
Interventions: OTHER: kinesio tape|OTHER: Sham taping|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Study of Lemborexant as an Adjunctive Treatment for Buprenorphine/Naloxone for Opioid Use Disorder
Status: COMPLETED
Conditions: Drug Interaction|Analgesics|Opioid Use Disorder
Interventions: DRUG: Lemborexant|DRUG: Placebo|DRUG: Buprenorphine-naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Observe Vedolizumab and Anti-tumour Necrosis Factors (Anti-TNFs) Outcomes in Real-world Biologic Ulcerative Colitis (UC) and Crohn's Disease (CD) Participants
Status: COMPLETED
Conditions: Colitis, Ulcerative|Crohn Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Hepatorenal Syndrome-Acute Kidney Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatorenal Syndrome|Cirrhosis, Liver|Acute-On-Chronic Liver Failure|AKI|Refractory Ascites
Interventions: DIAGNOSTIC_TEST: Echocardiographic assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Building Better Caregivers Online: An Online Workshop for Caregivers of Those With Traumatic Brain Injury, Post Traumatic Stress Disorder, or Alzheimer's or Other Dementia
Status: COMPLETED
Conditions: Dementia|Brain Injuries|Stress Disorders, Traumatic
Interventions: BEHAVIORAL: Building Better Caregivers Online Workshop
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: S0501 Fludarabine, Melphalan, and Donor Stem Cell Transplant Followed By Tacrolimus and Methotrexate in Treating Patients for Relapsed Lymphoma
Status: TERMINATED
Conditions: Lymphoma
Interventions: DRUG: fludarabine phosphate|DRUG: melphalan|DRUG: methotrexate|DRUG: tacrolimus|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Exploratory Phase 2 Study to Evaluate the Safety and Efficacy of MB12066 in Patients With Nonalcoholic Fatty Liver Disease(NAFLD) Except Cirrhosis
Status: TERMINATED
Conditions: Nonalcoholic Fatty Liver Disease
Interventions: DRUG: MB12066 200mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Oral L-Citrulline in Patients Taking Simvastatin With Peripheral Arterial Disease
Status: UNKNOWN
Conditions: Peripheral Arterial Disease|Intermittent Claudication
Interventions: DRUG: L-citrulline tablets, 1000 mg|DRUG: Placebo tablets matching L-citrulline tablets|DRUG: Background simvastatin at a stable dose of 40 mg qHS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Lumbar Spinal Fibrosis and TNF Alpha Inhibition
Status: COMPLETED
Conditions: Post Operative Sciatica by Lumbar Spinal Fibrosis
Interventions: DRUG: TNF blocker|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT