pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Automatic Recruitment Maneuver on Peroperative Lung Mechanics of Obese Laparoscopic Abdominal Surgery Patients
Status: UNKNOWN
Conditions: Recruitment|Obesity, Morbid|Laparoscopy
Interventions: PROCEDURE: Recruitment maneuver|PROCEDURE: No recruitment maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Multilevel Models of Therapeutic Response in the Lungs
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Hypertonic Saline|DRUG: Isotonic Saline|DRUG: Indium-DTPA|DRUG: Technetium Sulfur Colloid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase II Clinical Trial to Evaluate the Safety and Efficacy of TQB2450 Injection Combined With Anlotinib Capsule and Chemotherapy in the Treatment of Immunoresistant Advanced Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small-cell Lung Cancer
Interventions: DRUG: TQB2450 +Anlotinib+Docetaxel|DRUG: TQB2450 +Androtinib Placebo+Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Translumenal Endoscopic Omental Patch Closure of Perforated Viscus
Status: COMPLETED
Conditions: Peptic Ulcer
Interventions: DEVICE: Endoscopic Translumenal Omental Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: The Effect of Dronabinol on Ocular Hemodynamics in Patients With Primary Open Angle Glaucoma
Status: RECRUITING
Conditions: Retinal Blood Flow
Interventions: DRUG: Dronabinol 5 MG|DRUG: Dronabinol 10 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Safety and Efficacy of a New Silicone Hydrogel Contact Lens Design
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: B&L Investigational Contact Lens|DEVICE: B&L PureVision Contact Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Chemotherapy With CD133+ Select Autologous Hematopoietic Stem Cells for Children With Solid Tumors and Lymphomas
Status: COMPLETED
Conditions: Neuroblastoma|Central Nervous System Tumors|Lymphomas|Wilms Tumor
Interventions: PROCEDURE: Stem Cell Transplantation|DRUG: Busulfan, Melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assess Functional Outcomes in Anemic, Critically Ill, Trauma Patients When Taking Epoetin Alfa
Status: TERMINATED
Conditions: Anemia
Interventions: DRUG: PROCRIT|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Natural History of Participants With LGMD2E/R4, LGMD2D/R3, LGMD2C/R5, and LGMD2A/R1 ≥ 4 Years of Age, Who Are Managed in Routine Clinical Practice
Status: RECRUITING
Conditions: Limb-girdle Muscular Dystrophy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer
Status: RECRUITING
Conditions: Cancer
Interventions: DRUG: Darolutamide (Nubeqa, BAY1841788)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: HIV & Drug Abuse Prevention for South African Men
Status: COMPLETED
Conditions: Substance-Related Disorders|Human Immunodeficiency Virus|Alcoholism
Interventions: BEHAVIORAL: Soccer League (SL)|BEHAVIORAL: Soccer League/Vocational Training (SL-V)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mucosal Microbiome in Human Gastric Intestinal Metaplasia and Duodenal Tissue.
Status: UNKNOWN
Conditions: Mucosal Microbiome|Gastric Intestinal Metaplasia|Duodenum
Interventions: OTHER: endomicroscopy, targeted biopsy and 16s rRNA gene sequencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CTC, Free DNA, Stem Cells and EMT-related Antigens as Biomarkers of Activity of Cabazitaxel in CRPC.
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer|Metastatic Cancer|Castration-resistant Prostate Cancer|Circulating Tumor Cells
Interventions: PROCEDURE: blood and FFPE sample collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Topical Arnica and Mucopolysaccharide Polysulfate on Postoperative Pain, Edema and Trismus
Status: COMPLETED
Conditions: Impacted Third Molar Tooth
Interventions: DRUG: : Arnica montana|DRUG: Mucopolysaccharide polysulfate|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study of TUTI-16 in HIV-1 Infected and Uninfected Subjects
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: TUTI-16 (0.2mg)|BIOLOGICAL: TUTI-16 (1.0 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Unrelated Umbilical Cord Blood Transplantation Augmented With ALDHbr Umbilical Cord Blood Cells
Status: COMPLETED
Conditions: MDS|Anemia, Aplastic|Inborn Errors of Metabolism|Congenital Marrow Failure|Congenital Immunodeficiency Syndrome
Interventions: BIOLOGICAL: ALDHbr Umbilical Cord Blood Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Oxygen Therapy Effect in COVID-19 RCT (HBOTCOVID19)
Status: COMPLETED
Conditions: COVID-19|Desaturation of Blood
Interventions: DEVICE: Hyperbaric oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Maintenance Treatment of Apatinib/Capecitabine Versus Observation in Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Stomach Neoplasms|Gastrointestinal Neoplasms|Stomach Diseases|Digestive System Neoplasms|Capecitabine|Apatinib|Neoplasms|Molecular Mechanisms of Pharmacological Action
Interventions: DRUG: Apatinib|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VolumE maNagement Under Body Composition Monitoring in Critically Ill patientS on CRRT
Status: UNKNOWN
Conditions: Renal Dialysis|Fluid Overload
Interventions: DEVICE: InBody group|OTHER: IO group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IV Sedation Plus TAP Block for Placement of Percutaneous Endoscopic Gastrostomy Tube
Status: COMPLETED
Conditions: Transversus Abdominis Plane (TAP) Block
Interventions: PROCEDURE: IV midazolam and propofol-based sedation combined with ultrasound-guided, left side TAP block|PROCEDURE: IV midazolam and propofol-based sedation with Local Anesthetic infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Erlotinib Hydrochloride in Treating Patients With Advanced Esophageal Cancer or Stomach Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Esophagus|Adenocarcinoma of the Gastroesophageal Junction|Recurrent Esophageal Cancer|Squamous Cell Carcinoma of the Esophagus|Stage III Esophageal Cancer|Stage IV Esophageal Cancer
Interventions: DRUG: erlotinib hydrochloride|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study (Candesartan 16 mg and Amlodipine 5 mg) - A
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: CKD-330 16/5mg - A|DRUG: Candesartan 16mg and Amlodipine 5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of a Computer-Assisted Personalized Sedation (CAPS) Device for Propofol Delivery During Endoscopy
Status: COMPLETED
Conditions: Colonoscopy|Endoscopy, Digestive System|Conscious Sedation
Interventions: DEVICE: Computer-Assisted Personalized Sedation (CAPS) Device (SEDASYS® System)|OTHER: benzodiazepines and opioid sedation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Azithromycin Combination Therapy for the Treatment of Severe Malaria
Status: COMPLETED
Conditions: Falciparum Malaria
Interventions: DRUG: Artesunate|DRUG: Azithromycin + Artesunate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of a Homeopathic Therapy in Combination With Cyclosporin (Restasis) in the Treatment of Dry Eye Disease
Status: TERMINATED
Conditions: Dry Eye Syndromes
Interventions: DRUG: Euphrasia-based homeopathic therapy|DRUG: Cyclosporin solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Taspoglutide Versus Placebo for the Treatment of Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Diet and Exercise.
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: placebo|DRUG: taspoglutide|DRUG: taspoglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biological Sample Repository for Gastrointestinal Disorders
Status: SUSPENDED
Conditions: Obesity|Obesity, Morbid|Obesity, Primary|Gastro-Intestinal Disorder|Overweight and Obesity|Overweight|Overweight or Obesity|Diabetes Type 2|Diabetes Mellitus|Diabetes Mellitus, Type 2|Hypertension|Hyperlipidemias|Sleep Apnea|GERD|Gastroesophageal Reflux|Musculoskeletal Pain Disorder|Cancer
Interventions: DIAGNOSTIC_TEST: Blood Collection|DIAGNOSTIC_TEST: Urine Collection|DIAGNOSTIC_TEST: Tissue Sample Collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Distal Radial Artery Approach to Prevent Radial Artery Occlusion (DAPRAO)
Status: COMPLETED
Conditions: Radial Artery Occlusion
Interventions: PROCEDURE: Distal radial artery approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Improving Patient Reported Outcome Measures in Catheter Ablation
Status: NOT_YET_RECRUITING
Conditions: Ventricular Tachycardia|ICD|Quality of Life
Interventions: OTHER: Validated quality of life questionnaire (EQ-5D & C-CAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Status and Develepment Mental Quality of Life COPD/IPF Inpatients Before and After Pulmonary Rehabilitation
Status: TERMINATED
Conditions: Idiopathic Pulmonary Fibrosis and COPD
Interventions: PROCEDURE: Pulmonary rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: PVS: Innovative Programs For Healthy Lifestyle Promotion in Primary Care: 'Prescribe Healthy Life'
Status: UNKNOWN
Conditions: Health Promotion|Health Education|Patient Education|Counseling|Behavior Therapy|Health Behavior
Interventions: BEHAVIORAL: PVS: Programa de Vida Saludable
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Test Whether Spesolimab Helps People With a Skin Disease Called Netherton Syndrome
Status: RECRUITING
Conditions: Netherton Syndrome
Interventions: DRUG: Spesolimab - solution for infusion|DRUG: Placebo matching to spesolimab - solution for infusion|DRUG: Spesolimab - solution for injection|DRUG: Placebo matching to spesolimab - solution for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of RC48-ADC for the Treatment of HER2-expression Metastatic Breast Cancer With Abnormal Activation of PAM Pathway
Status: UNKNOWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: RC48-ADC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: plasmApuane CoV-2 : Efficacy and Safety of Immune Covid-19 Plasma in Covid-19 Pneumonia in Non ITU Patients
Status: UNKNOWN
Conditions: Covid-19 Pneumonia
Interventions: BIOLOGICAL: immune plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Korean Vascular Intervention Society Multicenter Registry Study on Outcomes of Endovascular Therapy in Lower Limb Artery Diseases (K-VIS ELLA): (A Retrospective & Prospective Observational Study)
Status: RECRUITING
Conditions: Peripheral Arterial Disease(PAD)
Interventions: PROCEDURE: endovascular treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Web-Base App To Improve Aromatase Inhibitor Adherence
Status: COMPLETED
Conditions: Breast Neoplasm Female
Interventions: BEHAVIORAL: Prompts to report symptoms via study app|BEHAVIORAL: Clinical Alerts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tonometry(1) and Duplex Ultrasound(2) to Predict CV Events in to be Treated Patients With an AAA
Status: RECRUITING
Conditions: Abdominal Aortic Aneurysm|Cardiovascular Events
Interventions: DIAGNOSTIC_TEST: Carotid Artery Reactivity test (CAR test)|DIAGNOSTIC_TEST: Arterial Stiffness
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: R-CHOP Combined With Lenalidomide in the First-line Treatment for Patients With Diffuse Large B Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: Rituximab|DRUG: Lenalidomide|DRUG: Cyclophosphamide|DRUG: Epirubicin|DRUG: Vincristine|DRUG: Prednisone|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EZN-2208 (Pegylated SN-38) in Combination With Bevacizumab in Refractory Solid Tumors
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: EZN-2208|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Dabrafenib+Trametinib in the Adjuvant Treatment of Stage III BRAF V600+ Melanoma After Complete Resection to Evaluate the Impact on Pyrexia Related Outcomes
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: DRUG: Dabrafenib|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Frequency of Screening and SBT Technique Trial: The FAST Trial
Status: UNKNOWN
Conditions: Critically Ill
Interventions: PROCEDURE: Once daily screening|PROCEDURE: Twice daily screening|PROCEDURE: PS SBTs|PROCEDURE: T-piece SBTs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Changes of the Neuronal Activity in the Subthalamic Nucleus Under Remifentanil Sedation During Stereotactic Electrode Implantation
Status: UNKNOWN
Conditions: Movement Disorders|Effect of Remifentanil
Interventions: DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pilot Study To Evaluate The CreatiVasc Hemoaccess Valve System In Patients Requiring Arteriovenous Graft Placement
Status: TERMINATED
Conditions: End Stage Renal Disease
Interventions: DEVICE: Hemoaccess Valve System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: An International Trial to Evaluate the Efficacy and Safety of SABER®-Bupivacaine for Postoperative Pain Control in Patients Undergoing Hysterectomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: SABER-Bupivacaine Treatment 1a|DRUG: Placebo SABER-Bupivacaine Treatment 1b|DRUG: Bupivacaine HCl Treatment 1c|DRUG: SABER-Bupivacaine Treatment 2a|DRUG: Placebo SABER-Bupivacaine Treatment 2b|DRUG: Bupivacaine HCl Treatment 2c
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimization of Cervical Cancer Screening Among Women Living With HIV in Latin American Countries
Status: RECRUITING
Conditions: Cervix Cancer|HPV Infection|Cervical High Grade Squamous Intraepithelial Lesion|HIV Infections
Interventions: DIAGNOSTIC_TEST: Xpert HPV|DIAGNOSTIC_TEST: S5 DNA methylation classifier
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Polymeric Micellar Paclitaxel, Platinum Combined With Sindilizumab Injection for Advanced Non-squamous NSCLC
Status: NOT_YET_RECRUITING
Conditions: Non-squamous NSCLC
Interventions: DRUG: paclitaxel polymeric micelles for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amplitude Titration to Improve ECT Clinical Outcomes
Status: RECRUITING
Conditions: Depression|ECT|Cognitive Change
Interventions: DEVICE: Soterix Medical Incorporated 4x1 adapter|DEVICE: Traditional ECT device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Kneipp Hydrotherapy With Conventional Physiotherapy in the Treatment of Osteoarthritis of the Hip or Knee: Protocol of a Prospective Randomised Controlled Clinical Trial
Status: UNKNOWN
Conditions: Osteoarthritis of the Hip or Knee
Interventions: PROCEDURE: Physiotherapy|PROCEDURE: Affusion|PROCEDURE: Affusion/ Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Neo-adjuvant Study Assessing TCH (Docetaxel, Carboplatin and Trastuzumab) and TCHL (Docetaxel, Carboplatin, Trastuzumab and Lapatinib) in HER-2 Positive Breast Cancer Patients.
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Docetaxel, Carboplatin and Trastuzumab|DRUG: Docetaxel, Carboplatin, Trastuzumab and Lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of NM21-1480 in Adult Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Advanced Solid Tumor|Non-small Cell Lung Cancer|Colorectal Cancer|Squamous Cell Carcinoma|Ovarian Carcinoma|Peritoneal Carcinoma|Fallopian Tube Cancer|Head and Neck Squamous Cell Carcinoma|Triple Negative Breast Cancer
Interventions: BIOLOGICAL: NM21-1480
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Neoadjuvant TACiE in Locally Advanced Gastric Cancer
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Oxaliplatin|DRUG: Teysuno|PROCEDURE: Transarterial arterial chemoinfusion and embolism (TACiE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention Study to Assess the Effects of Moderate and High Intensity Aerobic Training on Physical Capacity and Activity Level in Persons With Incomplete Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: OTHER: High intensity training|OTHER: Moderate intensity training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: How Different Sedatives Affect Hip Fracture Patient's Postoperative Delirium
Status: UNKNOWN
Conditions: Delirium in Old Age
Interventions: DRUG: Dexmedetomidine Hydrochloride|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Various Sedation Regimens on the Incidence of Delirium
Status: UNKNOWN
Conditions: Delirium
Interventions: DRUG: Dexmedetomidine,midazolam|DRUG: Propofol,midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Spinal Manipulation on Electromyography of the Masseter Muscle
Status: COMPLETED
Conditions: Bruxism|Muscle Disorder
Interventions: OTHER: Cervical Manipulation|OTHER: Sham Cervical Manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: APT™ T3X on the COVID-19 Contamination Rate
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Tetracycline hydrochloride 3%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability Study of GIM-531 in Advanced Solid Tumors
Status: RECRUITING
Conditions: Melanoma Stage IV|Solid Tumor
Interventions: DRUG: GIM-531|DRUG: Anti-PD-1 monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Preemptive Intravenous Ibuprofen on Intraoperative Analgesia in Third Molar Teeth
Status: UNKNOWN
Conditions: Preemptive Intravenous Ibuprofen|Intraoperative Analgesia
Interventions: DRUG: arveles|DRUG: intrafen 800 mg|OTHER: plasebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Insomnia Treatment and EMA (Ecological Momentary Assessment) Outcomes
Status: RECRUITING
Conditions: Insomnia
Interventions: BEHAVIORAL: Baseline surveys, Cognitive testing and EMAs|DEVICE: Actiwatch|DRUG: suvorexant (or placebo)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brief Mindfulness Based Intervention to Improve Psychological Wellbeing
Status: COMPLETED
Conditions: Stress, Psychological
Interventions: BEHAVIORAL: brief mindfulness based intervention|BEHAVIORAL: Progressive muscle relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Simple Non-invasive Breathing Device to Improve Pulmonary Flow Pusatility in Single Ventricle Post Fontan
Status: ACTIVE_NOT_RECRUITING
Conditions: Single-ventricle
Interventions: DEVICE: Hands-free oral-positive pressure device (oPEP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate Safety and Effectiveness of Pancreatic Cells Derived From Pigs (OPF-310) in Patients With Type 1 Diabetes Mellitus
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 1|Hypoglycemia
Interventions: DRUG: OPF-310
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gingival Displacement by Polytetrafluoroethylene & Conventional Retraction Cord
Status: COMPLETED
Conditions: Gingival Pocket
Interventions: DEVICE: PTFE Retraction Cord
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate Safety & Tolerability of AGI-134 in Solid Tumour
Status: COMPLETED
Conditions: Superficial, Palpable, Unresectable/Metastatic Solid Tumour
Interventions: DRUG: AGI-134
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Injection of Oncolytic Virus Injection (RT-01) in Patients With Relapsed or Refractory T-cell Lymphoma
Status: UNKNOWN
Conditions: T-cell Lymphoma|Virus|Intravenous Injection
Interventions: BIOLOGICAL: Oncolytic Virus Injection(RT-01)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OPTIMIZING OCULAR OUTCOMES: A DUAL-ARMED STUDY FOR PERIORBITAL BURN MANAGEMENT
Status: NOT_YET_RECRUITING
Conditions: Periorbital Burns
Interventions: DRUG: Steroid/Antibiotic|DRUG: 5-FU/Kenalog
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritional Counseling to Change Eating Behavior, Metabolism and Anthropometry in Adults With Abdominal Obesity
Status: COMPLETED
Conditions: Obesity, Abdominal
Interventions: OTHER: Nutritional counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Hypertrophic Regression With N-Acetylcysteine in HCM
Status: COMPLETED
Conditions: Hypertrophic Cardiomyopathy
Interventions: DRUG: N-acetylcysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Asthmatics to Determine the Efficacy and Dose Response of Repeat Doses of GW870086X on Forced Expiratory Volume in 1 Second (FEV1)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: GW870086 2mg|DRUG: GW870086 4mg|DRUG: GW870086 Placebo|DRUG: GW870086 1mg|DRUG: GW870086 3mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Nursing Intervention in First-time Mothers
Status: COMPLETED
Conditions: Mothers|First Birth
Interventions: BEHAVIORAL: Maternal support to become mother|BEHAVIORAL: Control Group: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Influence of Timing on Motor Learning
Status: COMPLETED
Conditions: Cerebrovascular Accident
Interventions: OTHER: Conventional hand exercise|DEVICE: MusicGlove|OTHER: Conventional Arm Exercise|DEVICE: Resonating Arm Exerciser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brief ROC Training Effects on Alcohol Drinking
Status: TERMINATED
Conditions: Binge Drinking|Heavy Drinking|Young Adult|Heavy Drinker|Alcohol Drinking|Alcohol Drinking in College|Drinking Behavior|Drunkenness|Drinking Excessive|Drinking Problem|Drink Too Much|College Drinking
Interventions: BEHAVIORAL: Regulation of craving|BEHAVIORAL: Control (NO REGULATION)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Operative Treatment of Extraarticular Colles' Fractures of the Distal Radius (OTEC)
Status: UNKNOWN
Conditions: Colles' Fracture|Radius Fractures
Interventions: PROCEDURE: Osteosynthesis with palmar locking plate|PROCEDURE: Osteosynthesis with external fixator|PROCEDURE: Osteosynthesis with Kirschner wires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy for Chronic Pain in Adults With Cerebral Palsy
Status: NOT_YET_RECRUITING
Conditions: Cerebral Palsy|Pain, Chronic|Pain Catastrophizing|Brain Diseases|Central Nervous System Diseases|Coping Strategies|Catastrophizing Pain|Coping Behavior
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Chronic Pain|OTHER: Pain education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rechallenge With Panitumumab Driven by RAS Dynamic of Resistance
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Panitumumab 20 MG/ML Intravenous Solution [VECTIBIX]|DIAGNOSTIC_TEST: Molecular Screening
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Pharmacokinetics of NKTR-118 in Subjects With Renal Impairment Compared to That in Subjects With Normal Renal Function
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: NKTR118 Group1|DRUG: NKTR118 Group 2|DRUG: NKTR118 Group3|DRUG: NKTR118
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Absorption of Peptides, Fluid, and Electrolytes in Patients With an Ileostomy
Status: COMPLETED
Conditions: Nutritional Deficiency|Ileostomy; Functional Disturbance|Short Bowel Syndrome|Absorption; Disorder, Protein
Interventions: DIETARY_SUPPLEMENT: Hydrolysed whey|DIETARY_SUPPLEMENT: Intact whey|DIETARY_SUPPLEMENT: Caseinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Cohort Study of Germline Variant Carriers With BRCA1 or BRCA2
Status: RECRUITING
Conditions: BRCA1 and/or BRCA2 Variant Carriers|Ovarian Carcinoma|Fallopian Tube Carcinoma|Peritoneal Carcinoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Methadone and Ketamine for Spinal Surgery
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Ketamine|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GENOCARE: A Prospective, Randomized Clinical Trial of Genotype-Guided Dosing Versus Usual Care
Status: RECRUITING
Conditions: Colorectal Cancer|Pancreatic Cancer
Interventions: DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Chromium Effects on Insulin and Vascular Function in People at Risk for Diabetes
Status: COMPLETED
Conditions: Obesity|Pre-diabetes|Insulin Resistance|Impaired Glucose Tolerance|Impaired Fasting Glucose
Interventions: DIETARY_SUPPLEMENT: Chromium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Breast Carcinoma|Advanced Malignant Solid Neoplasm|Advanced Prostate Carcinoma|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Castration-Resistant Prostate Carcinoma|Metastatic Breast Carcinoma|Metastatic Malignant Solid Neoplasm|Metastatic Prostate Carcinoma|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8|Prognostic Stage IV Breast Cancer AJCC v8|Stage III Prostate Cancer AJCC v8|Stage IIIA Prostate Cancer AJCC v8|Stage IIIB Prostate Cancer AJCC v8|Stage IIIC Prostate Cancer AJCC v8|Stage IV Prostate Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8|Stage IVB Prostate Cancer AJCC v8|Triple-Negative Breast Carcinoma|Unresectable Solid Neoplasm
Interventions: DRUG: Docetaxel|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: PI3Kbeta Inhibitor AZD8186
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemopreventive Effect of Combination of Celecoxib and Metformin in Patients With Familial Adenomatous Polyposis
Status: RECRUITING
Conditions: Familial Adenomatous Polyposis
Interventions: DRUG: celecoxib monotherapy|DRUG: celecoxib and metformin combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Nivolumab in Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL) and Relapsed/Refractory Primary Testicular Lymphoma (PTL)
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Administration of Venetoclax to Promote Apoptosis of HIV-infected Cells and Reduce the Size of the HIV Reservoir Among People Living With HIV on ART
Status: RECRUITING
Conditions: HIV-1-infection
Interventions: DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Yang Yin Fu Zheng Therapy in HBV Associated Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Yang Yin Fu Zheng therapy|DRUG: Routine medical care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD3/CD19 Depleted or CD3 Depleted/CD56 Selected Haploidentical Donor Natural Killer (NK) Cell Based Therapy for AML Patients Not in CR
Status: TERMINATED
Conditions: Acute Myelogenous Leukemia
Interventions: DEVICE: Interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation-2 (TELSTAR-2)
Status: NOT_YET_RECRUITING
Conditions: Coma|Electrographic Status Epilepticus
Interventions: DRUG: anti-seizure medication + sedative agent(s)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection and Prevention of Nerve Injury in Shoulder Arthroplasty Surgery
Status: COMPLETED
Conditions: Neuropathy|Nerve Injury
Interventions: DEVICE: Automated Somatosensory Evoked Potential device (EPAD@)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transcutaneous Submandibular Gland Biopsy: Feasibility of Repeat Biopsy as a Progression Marker for Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: PROCEDURE: Submandibular gland biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Transnasal Sphenopalatine Ganglia Block for Management of Chronic Migraines in Pediatric Patients
Status: WITHDRAWN
Conditions: Migraine in Children|Pain, Neuropathic
Interventions: OTHER: Headache Journal|DRUG: Sphenopalatine Block|DEVICE: Tx360
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Descartes-08 Consolidation Treatment in Patients With High-Risk Multiple Myeloma High-Risk Multiple Myeloma Who Have Residual Disease After Induction Therapy
Status: TERMINATED
Conditions: Myeloma Multiple
Interventions: BIOLOGICAL: Descartes 08
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Sirukumab in Subjects With Polymyalgia Rheumatica
Status: WITHDRAWN
Conditions: Polymyalgia Rheumatica
Interventions: DRUG: Sirukumab|DRUG: Placebo to match sirukumab|DRUG: Prednisone /Prednisone placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cross-Over Broccoli Sprouts Trial
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: broccoli sprouts extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Early Interferon-beta Treatment for West-Nile Virus Infection
Status: RECRUITING
Conditions: West Nile Virus|West Nile Fever Encephalitis|West Nile Fever Myelitis|West Nile Fever With Other Complications
Interventions: DRUG: Rebif 44 MCG Per 0.5 ML Prefilled Syringe|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Bike Skills Training for Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: Novel task-specific bike skills training program|OTHER: Parent-led home-based bike skills training program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Empowering Adolescents to Lead Change Using Health Data
Status: RECRUITING
Conditions: Healthy
Interventions: BEHAVIORAL: Behavioral interventions targeting multiple risk behaviors as well as protective factors|OTHER: School-level interventions targeting the school environment and system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: MINDD 3: Prediabetes and Delay Discounting
Status: COMPLETED
Conditions: PreDiabetes
Interventions: BEHAVIORAL: Episodic Future Thinking|BEHAVIORAL: Episodic Recent Thinking|BEHAVIORAL: Scarcity Narrative|BEHAVIORAL: Neutral Narrative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of 68Ga /131I SGMIB-ZT-199 PET Imaging Targeting HER2-positive in the Diagnosis of Metastatic Breast Cancer
Status: RECRUITING
Conditions: HER2-positive Breast Cancer
Interventions: RADIATION: 68Ga/131I-SGMIB-ZT-199
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Two Water-Based Potassium Oxalate Desensitizers on Dental Hypersensitivity
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: DEVICE: Potassium oxalate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of BTA798 in Asthmatic Adults With Symptomatic Human Rhinovirus Infection
Status: COMPLETED
Conditions: Rhinovirus
Interventions: DRUG: BTA798|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Various Techniques of Horizontal Ridge Augmentation
Status: COMPLETED
Conditions: Horizontal Ridge Deficiency
Interventions: PROCEDURE: decompression technique|PROCEDURE: guided bone regenaration using Ethoss|PROCEDURE: ridge splitting technqiue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of High Density Voltage and Fractionation Map Guided Ablation in Patients With Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: AF ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pupillometry - Future of Objective Pain Reaction Measurement While Unconscious
Status: COMPLETED
Conditions: Pain
Interventions: DEVICE: Pupil reflex dilation measurement (PRD)|DEVICE: PPI (Pupillary Pain Index)|DRUG: lidocaine|DRUG: Placebo|DEVICE: Bispectral Index (BIS)|DEVICE: HR|DEVICE: BP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Ferumoxytol- and Gadolinium-Labeled MRI in Measuring Tumors Before or After Treatment in Patients With Primary or Metastatic Brain Tumors
Status: TERMINATED
Conditions: Metastatic Malignant Neoplasm in the Brain|Primary Brain Neoplasm
Interventions: PROCEDURE: 3 Tesla Magnetic Resonance Imaging|PROCEDURE: Dynamic Contrast-Enhanced Magnetic Resonance Imaging|PROCEDURE: Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging|DRUG: Ferumoxytol|DRUG: Gadolinium|PROCEDURE: High Field Strength Magnetic Resonance Imaging|PROCEDURE: Susceptibility Weighted Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Short-term Effects of Preoperative Exercise in Moderate-to-high Perioperative Risk Lung Cancer Patients
Status: RECRUITING
Conditions: Lung Cancer
Interventions: BEHAVIORAL: moderate-intensity continuous training|BEHAVIORAL: high-intensity interval training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Study of Digoxin and AT-527 (R07496998)
Status: COMPLETED
Conditions: Healthy Volunteers Study
Interventions: DRUG: AT-527 + digoxin|DRUG: AT-527 + digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fibre suppLements fOR Pre-diAbetes - An Assessment Oral Fibre Supplements on Pre-diabetes Outcome Measures
Status: COMPLETED
Conditions: Pre-diabetes
Interventions: DIETARY_SUPPLEMENT: Myota Metabolic Regulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Duodenal Switch With a Standard Versus Long Alimentary Limb
Status: COMPLETED
Conditions: Obesity, Morbid|Bariatric Surgery Candidate|Metabolism Disorder
Interventions: PROCEDURE: Long alimentary limb BPD-DS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Immune Response Following Lobectomy Along With or Without Bilateral Transcervical Mediastinal Lymphadenectomy
Status: UNKNOWN
Conditions: Lung Neoplasm Malignant
Interventions: PROCEDURE: Lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of IV Diclofenac (DIV075V)for Pain After Elective Orthopedic Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: IV Diclofenac|DRUG: IV ketorolac|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Therapies for the Treatment of Severe Aplastic Anemia
Status: COMPLETED
Conditions: Severe Aplastic Anemia (SAA)
Interventions: DRUG: antithymocyte globulin|DRUG: cyclophosphamide|DRUG: cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Study on the Diagnosis and Intervention of New Biomarkers on the Prodromal Stage of Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer's Disease
Interventions: DIAGNOSTIC_TEST: MicRNAs battery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of a New Botanical Extracts Combination on Quality of Life in Menopausal Spanish Women
Status: COMPLETED
Conditions: Menopause|Dietary Supplements|Quality of Life
Interventions: DIETARY_SUPPLEMENT: Botanical dry extracts combination|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study to Evaluate EP0062 in Patients With Relapsed Locally Advanced or Metastatic Androgen Receptor Positive (AR+)/HER2-/ER+ Breast Cancer
Status: RECRUITING
Conditions: Hormone Receptor-positive Breast Cancer|Hormone Receptor Positive HER-2 Negative Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: EP0062
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Stress Urinary Incontinence by Injection of Autologous Muscle Fibers Into the Urethral Sphincter.
Status: UNKNOWN
Conditions: Urinary Incontinence, Stress
Interventions: PROCEDURE: Periurethral injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT