pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Studying the Benefits of Adjuvant Sequential vs. Combined Taxane Based Chemotherapy, Followed by Different Biological Treatment Strategies in Early, HER2-positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: 3 x FEC 3 x DOC / Gemcitabine|DRUG: 3 x FEC 3 x DOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cemented Versus Cementless Unicompartmental Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Cementless Oxford Unicompartmental Knee Arthroplasty|DEVICE: Cemented Oxford Unicompartmental Knee Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Entecavir Plus Adefovir in Lamivudine-Resistant Patients
Status: WITHDRAWN
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Lamivudine|DRUG: Entecavir|DRUG: Adefovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NBP in Patients With Moyamoya Disease of High Risk for Ischemic Cerebrovascular Events
Status: UNKNOWN
Conditions: Moyamoya Disease|Ischemic Cerebral Infarction|Ischemic Stroke|Ischemic Cerebrovascular Accident|Transient Ischemic Attack
Interventions: DRUG: dl-3-n-butylphthalide (NBP)|DRUG: Normal Saline 0.9% Infusion Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Lipid-Lowering Effect and Hypotensive Effect of Shanzha Fruit Drink in Patients
Status: COMPLETED
Conditions: Hyperlipidemia|Hypertension
Interventions: DIETARY_SUPPLEMENT: Shanzha Fruit drink or placebo drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MIld to MOderate Acute Pancreatitis: Early naSogastric Tube Feeding Compared With pAncreas Rest (MIMOSA)
Status: COMPLETED
Conditions: Acute Pancreatitis
Interventions: PROCEDURE: Enteral tube feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Huang Lian (Chinese Herb) in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: Chinese Herb Huanglian (Coptis chinesis)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: This Study Tests How Healthy Men Tolerate Different Doses of BI 730357 and How the Metabolism of Midazolam is Affected by BI 730357
Status: COMPLETED
Conditions: Healthy|Psoriasis
Interventions: DRUG: BI 730357|DRUG: Placebo|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Healing Touch or Guided Imagery In Treating Pain, Fatigue, Nausea, and Anxiety in Patients Undergoing Chemotherapy
Status: COMPLETED
Conditions: Anxiety Disorder|Fatigue|Malignant Neoplasm|Nausea and Vomiting|Pain
Interventions: OTHER: questionnaire administration|PROCEDURE: therapeutic touch|BEHAVIORAL: management of therapy complications|BEHAVIORAL: management of therapy complications|PROCEDURE: standard follow-up care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Piezo-ICSI to Improve the Developmental Potential of Fertilized Oocytes in Aged Infertility Women With Assisted Reproductive Technology
Status: RECRUITING
Conditions: Infertility, Female|Intracytoplasmic Sperm Injections
Interventions: DEVICE: Piezo-ICSI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Lenalidomide Monotherapy in Red Blood Cell Transfusion Dependent Subjects With Myelodysplastic Syndrome (MDS) Associated With Del (5q) Abnormality
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FB101 Intervention in Women Screened to Have Vaginal Dysbiosis (Dyscover-3)
Status: RECRUITING
Conditions: Vaginal Flora Imbalance
Interventions: OTHER: FB101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Bevacizumab Added to Trastuzumab Plus Docetaxel in the Neoadjuvant Setting in Participants With Early Stage HER2-Positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Bevacizumab|DRUG: Docetaxel|DRUG: Trastuzumab|PROCEDURE: Surgery|RADIATION: Radiotherapy|DRUG: Hormonal Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anlotinib Hydrochloride Capsules Combined With TQB2450 Injection in Esophageal Squamous Cell Carcinoma Patients
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma|Esophageal Neoplasms|Esophageal Diseases|Gastrointestinal Neoplasms|Gastrointestinal Diseases|Digestive System Neoplasms|Digestive System Diseases|Neoplasms by Site|Neoplasms by Histologic Type|Neoplasms, Squamous Cell|Carcinoma, Squamous Cell
Interventions: DRUG: Anlotinib hydrochloride|DRUG: TQB2450
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pediatric Precision Laboratory Advanced Neuroblastoma Therapy
Status: RECRUITING
Conditions: Neuroblastoma
Interventions: DRUG: Ceritinib|DRUG: dasatinib|DRUG: sorafenib|DRUG: vorinostat|DRUG: DFMO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ciprofloxacin Compared to Placebo in Diagnosing Prostate Cancer in Patients Undergoing Prostate Biopsy
Status: WITHDRAWN
Conditions: Prostate Cancer
Interventions: DRUG: ciprofloxacin|OTHER: placebo|OTHER: quality-of-life assessment|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Escalating Doses of IncobotulinumtoxinA (Xeomin®) in the Treatment of Glabellar Rhytids
Status: UNKNOWN
Conditions: Skin Aging|Elastosis Senilis
Interventions: BIOLOGICAL: incobotulinumtoxinA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VitaFlow™ II Transcatheter Aortic Valve System Pre-market Trial
Status: RECRUITING
Conditions: Aortic Stenosis
Interventions: DEVICE: VitaFlow™ II Transcatheter Aortic Valve System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Scapular Therapeutic Exercise on Essential Biomechanical and Neurophysiological Parameters in Shoulder Pain Conditions With Scapular Impairments
Status: COMPLETED
Conditions: Shoulder Pain
Interventions: OTHER: Experimental Scapular Therapeutic Exercise Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacodynamic Study of Sobetirome in X-Linked Adrenoleukodystrophy (X-ALD)
Status: WITHDRAWN
Conditions: X-Linked Adrenoleukodystrophy|Adrenomyeloneuropathy
Interventions: DRUG: Sobetirome
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retrovirus Epidemiology Donor Study I (REDS I)
Status: COMPLETED
Conditions: Acquired Immunodeficiency Syndrome|Blood Donors|Blood Transfusion|HIV Infections|HIV-1|HIV-2|HTLV-I|HTLV-II|Retroviridae Infections
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Efficacy of Little Lovely Dentist, Dental Song and Tell-show-do Techniques in Alleviating Dental Anxiety in Paediatric Patients
Status: COMPLETED
Conditions: Anxiety|Paediatric|Dental Anxiety|Behaviour
Interventions: BEHAVIORAL: Anxiety
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Safety and Pharmacokinetics of HH-120 Nasal Spray in Healthy Volunteers
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: HH-120 nasal spray, PartA cohort 1|DRUG: HH-120 nasal spray, Part A cohort 2-7|DRUG: HH-120 nasal spray, Part A cohort 8-9|DRUG: HH-120 nasal spray, Part B|OTHER: Placebo nasal spray, Part B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Non-Surgical Periodontal Therapy on Inflammatory Bowel Disease
Status: NOT_YET_RECRUITING
Conditions: Periodontitis|Inflammatory Bowel Diseases
Interventions: OTHER: ELISA (Enzyme-Linked ImmunoSorbent Assay)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficacy and Safety of Two Biphasic Defibrillators in Cardioversion of Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation|Arrythmia|Electric Countershock
Interventions: DEVICE: Schiller Defigard Touch 7 - DGT7, Schiller Medical, France|DEVICE: LIFEPAK 15, Physio-Control Inc., Redmond, WA, USA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Influencing Factors of Liwen Procedure in The Treatment of Hypertrophic Cardiomyopathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertrophic Obstructive Cardiomyopathy
Interventions: PROCEDURE: Percutaneous Intramyocardial Septal Radiofrequency Ablation for hypertrophic obstructive cardiomyopathy (Liwen Procedure)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Coronary CTO PCI Using Antegrade Wiring Strategy With a First-choice Gladius Guidewire (Gladius First)
Status: RECRUITING
Conditions: Coronary Artery Disease|Coronary Occlusion|Percutaneous Coronary Intervention
Interventions: PROCEDURE: CTO PCI with the first-choice Gladius guidewire|PROCEDURE: CTO PCI without the first-choice Gladius guidewire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Radiotherapy and Temozolomide for Newly Diagnosed High-grade Glioma
Status: TERMINATED
Conditions: Glioblastoma|Malignant Glioma|Brain Tumors|Anaplastic Astrocytoma
Interventions: RADIATION: Stem Cell Radiotherapy (ScRT) and Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Innovative Central Line Securement Device in the Pediatric Population
Status: TERMINATED
Conditions: Central Line Complication|Central Line Infection|Central Line-Associated Infection|Central Line Sepsis|Short Gut Syndrome|Quality of Life|Pediatric Disorder
Interventions: DEVICE: Wearable Central Line Securement Device (Vest)|OTHER: Traditional Securement Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Use of Venlafaxine in Reducing Pain in Primary Total Knee Replacement
Status: RECRUITING
Conditions: Acute Pain|Chronic Pain|Knee Pain Chronic|Neuropathic Pain
Interventions: DRUG: Venlafaxine 37.5 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Kytril (Granisetron) in the Prevention of Post-Operative Nausea and Vomiting (PONV) in Pediatric Subjects Undergoing Tonsillectomy or Adenotonsillectomy
Status: COMPLETED
Conditions: Post-Operative Nausea and Vomiting
Interventions: DRUG: granisetron|DRUG: granisetron
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects on Muscle Activity After Dry Needling in Myofascial Trigger Points of the Gastrocnemius Muscles
Status: UNKNOWN
Conditions: Myofascial Trigger Point Pain
Interventions: OTHER: Dry needling|OTHER: Sham dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Of Single And Multiple Ascending Doses Of PF-07054894 In Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-07054894|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Comparing Sotorasib With Durvalumab in People With Non-Small Cell Lung Cancer (NSCLC)
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Durvalumab|DRUG: Sotorasib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Everyday Life After a Tai Chi or Eurythmy Intervention in Elderly People at Risk of Falling: a Qualitative Exploration as a Sub-Study of the ENTAiER Study
Status: COMPLETED
Conditions: Increased Risk of Falls
Interventions: OTHER: Qualitative interview - eurythmy group|OTHER: Qualitative interview - tai chi group|OTHER: Qualitative interview - standard care group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Exercise With or Without Blueberries on Cardiovascular Risk Markers
Status: COMPLETED
Conditions: Risk Factors Cardiovascular Disease|Inflammation|Exercise|Sedentary Life
Interventions: BIOLOGICAL: Blueberries
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Second-generation Antihistamine Bepotastine on Cough Outcomes in Cough Patients With Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis|Cough
Interventions: DRUG: Bepotastine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Administration of ONS Based on Purple Sweet Potato in Head and Neck Cancer Patients With Radiotherapy
Status: RECRUITING
Conditions: Oral Nutritional Supplement
Interventions: DIETARY_SUPPLEMENT: immunonutrients oral nutritional supplements|DIETARY_SUPPLEMENT: standard oral nutritional supplements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Text Message Intervention to Improve Cardiac Rehab Participation
Status: TERMINATED
Conditions: Myocardial Infarction|Percutaneous Coronary Intervention|Coronary Artery Bypass Surgery|Heart Valve Repair or Replacement|Heart Transplant|Left Ventricular Assist Device|Chronic Stable Angina|Chronic Stable Heart Failure
Interventions: BEHAVIORAL: Text Messaging Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Safety and Tolerability of Twice-Daily Aclidinium Bromide/Formoterol Fumarate Fixed Dose Combination in Chinese Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Aclidinium Bromide/Formoterol Fumarate 400/12μg BID
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety in Patients With Primary Hypercholesterolemia
Status: UNKNOWN
Conditions: Primary Hypercholesterolemia
Interventions: DRUG: AGT2, AGZ|DRUG: AGT2|DRUG: AGT4, AGZ|DRUG: AGT4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Citrate Versus Heparin Anticoagulation: Effect on Molecules Clearances
Status: UNKNOWN
Conditions: Septic Shock
Interventions: DRUG: Anticoagulation to prevent clotting of the extracorporeal circuit. (regional citrate anticoagulation)|DRUG: Anticoagulation to prevent clotting of the extracorporeal circuit (Unfractionated heparin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Sulfasalazine in the Treatment of Liver Fibrosis/Cirrhosis.
Status: RECRUITING
Conditions: Cirrhosis, Liver|Fibrosis, Liver
Interventions: DRUG: Sulfasalazine enteric-coated tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fish Oil for Patients With Liver Disease Due to Parenteral Nutrition
Status: TERMINATED
Conditions: Total Parenteral Nutrition-induced Cholestasis
Interventions: DRUG: Soybean oil (Standard treatment)|DRUG: Soybean oil + Fish oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Evaluation of a Compassion-course for Healthcare Professionals
Status: RECRUITING
Conditions: Psychological Stress|Compassion|Occupational Health|Cognitive Behavioral Therapy
Interventions: BEHAVIORAL: Internet-based compassion course for stress managemant|BEHAVIORAL: General Internet-based cognitive behavioural course for stress management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of QVA149 in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: indacaterol/glycopyrrolate|DRUG: indacaterol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ranibizumab as Adjuvant Therapy for the Treatment of Choroidal Melanoma (Cohort 2)
Status: COMPLETED
Conditions: Choroidal Melanoma
Interventions: DRUG: Ranibizumab 2 mg|DRUG: 0.5 mg Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Real and Sham Diathermy vs Hand Massage in Lower Limbs Delayed Onset Muscle Soreness (DOMS)Effect on Knee Proprioception
Status: COMPLETED
Conditions: Musculoskeletal Pain
Interventions: OTHER: Massage|DEVICE: DIathermy|DEVICE: Sham diathermy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Immunogenicity of mRNA-4157 Alone and in Combination in Participants With Solid Tumors
Status: RECRUITING
Conditions: Solid Tumors
Interventions: BIOLOGICAL: mRNA-4157|BIOLOGICAL: Pembrolizumab|BIOLOGICAL: SoC Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Different Doses of Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Cataract Surgery
Status: RECRUITING
Conditions: Corneal Edema|Corneal Defect|Anterior Chamber Inflammation|Ocular Pain|Corneal Staining|Visual Outcome|CME - Cystoid Macular Edema
Interventions: DRUG: Dextenza 0.4Mg Ophthalmic Insert|DRUG: Prednisolone Acetate 1% Oph Susp|DRUG: Prolensa 0.07% Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Salvage Therapy for Patients With Advanced Features for Biochemical Relapse After Radical Prostatectomy for Localized Prostate Carcinoma In Correlation With Supposed Molecular-genetic Parameters of Higher Aggressiveness
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: Early salvage radiotherapy (eSRT)|RADIATION: Delayed Salvage radiotherapy (dSRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mycoprotein as the Basis of a Sustainable Diet to Support Muscle Mass Maintenance and Reconditioning in Older Adults.
Status: COMPLETED
Conditions: Aging|Sarcopenia
Interventions: OTHER: Protein, calorie and macronutrient controlled diet, derived from either omnivorous or non-animal sources, alongside unilateral resistance exercise, over a three-day period.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Impact of Electrocoagulation on Ovarian Reserve After Laparoscopic Excision of Ovarian Cyst
Status: COMPLETED
Conditions: Ovarian Cysts
Interventions: PROCEDURE: Ovarian cystectomy|PROCEDURE: Ovarian cystectomy|PROCEDURE: Ovarian cystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Dexamethasone and Epinephrine on the Duration of Sciatic Nerve Blocks With Ropivacaine
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Dexamethasone|DRUG: Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Biphasic Insulin Aspart 30 FlexPen™ in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Intensive Behavioral Training Program on Impulsivity and Inhibitory Control in Smokers
Status: UNKNOWN
Conditions: Tobacco Smoking|Nicotine Dependence|Impulsivity|Addiction|Substance Dependence
Interventions: BEHAVIORAL: Mindfulness Training|BEHAVIORAL: Cognitive-Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility of Intracoronary Hypothermia in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: OTHER: intracoronary infusion with saline on 22 and 4°C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of PF-06873600 in People With Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: HR+ HER2- Metastatic Breast Cancer, Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer, Triple Negative Breast Cancer, Male Breast Cancer
Interventions: DRUG: PF-06873600|DRUG: Endocrine Therapy 1|DRUG: Endocrine Therapy 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of HSK31858 in Participants With Non-Cystic Fibrosis Bronchiectasis
Status: RECRUITING
Conditions: Non-cystic Fibrosis Bronchiectasis (NCFBE)
Interventions: DRUG: HSK31858|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Mouth Rinses (and Chewing Gum) in Regard to Streptococcus Mutans Reduction
Status: TERMINATED
Conditions: Dental Caries
Interventions: DRUG: Chlorhexidine gluconate (0.12%)|DRUG: Sodium Fluoride (0.05%)|OTHER: Paraffin wax chewing gum (sugar-free)|OTHER: Deionized water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Square Step Exercises in Healthy Young Adults
Status: NOT_YET_RECRUITING
Conditions: Exercise|Square Step Exercises|Aerobic Exercise|Cognitive Function|Physical Fitness
Interventions: OTHER: Square Stepping Exercise training|OTHER: Aerobic Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Tissue Genesis® Icellator Cell Isolation System™ to Treat Critical Limb Ischemia
Status: UNKNOWN
Conditions: Critical Limb Ischemia
Interventions: DEVICE: TGI SVF material via intramuscular injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concordance of Hypoglycemia Measurement With Simultaneous Use of Two Devices for Continuous Glucose Measurement.
Status: RECRUITING
Conditions: Type 1 Diabetes|Hypoglycemia
Interventions: DEVICE: Continuos glucose monitoring and blood glucose measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: St. John's Wort Extract LI 160 for the Treatment of Atypical Depression
Status: COMPLETED
Conditions: Atypical Depression
Interventions: DRUG: St. John's Wort extract|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Citrate Versus Heparin Anticoagulation in Continuous Venovenous Hemofiltration
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: OTHER: regional anticoagulation with citrate|OTHER: HfCitPre
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of Fostamatinib Twice Daily on Blood Pressure in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: fostamatinib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of FOLFIRI Plus Bevacizumab in Colorectal Cancer Patients
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: 5-Fluorouracil|DRUG: Bevacizumab|DRUG: Leucovorin|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Outcomes Following In-office Tympanostomy Using the Tula® System: a Prospective, Multi-center Registry
Status: RECRUITING
Conditions: Otitis Media With Effusion|Acute Otitis Media|Otitis Media
Interventions: COMBINATION_PRODUCT: Iontophoresis and tube placement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomized Comparative Study of Erlotinib and Pemetrexed in the Maintenance Treatment of Advanced Lung Cancer Patients.
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Pemetrexed|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest of Intravitreal Corticotherapy as the First-line Treatment for Post-operative Endophthalmitis
Status: COMPLETED
Conditions: Post-operative Endophthalmitis
Interventions: PROCEDURE: Intravitreal injection of Betamethasone + antibiotics|PROCEDURE: Intravitreal injection of antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Posterior Lumbar Stress Reaction in Pediatric Patients. Treatment With or Without Soft Spinal Brace?
Status: NOT_YET_RECRUITING
Conditions: Back Pain|Stress Fracture
Interventions: DEVICE: soft spinal brace|OTHER: Resting from all sports activities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Using Biomarkers to Detect and Identify Cardiotoxicity and Describe Treatment (PREDICT)
Status: UNKNOWN
Conditions: Cardiac Toxicity|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: OTHER: Laboratory Biomarker Analysis|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing the Effect of Whey and Soy Protein on the Absorption of Pomegranate Polyphenols in the Human Body
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Pomegranate Juice|DIETARY_SUPPLEMENT: Soybean Flour Protein|DIETARY_SUPPLEMENT: Soy Isolate Protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Add-on to Thiazolidinedione (TZD) Failures
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Dapagliflozin|DRUG: Dapagliflozin|DRUG: Placebo matching Dapagliflozin|DRUG: Thiazolidinedione (Pioglitazone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diabetes Prevention Strategies in Women With Gestational Diabetes Mellitus (GDM)
Status: COMPLETED
Conditions: Gestational Diabetes|Obesity
Interventions: BEHAVIORAL: Lifestyle Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Three Dimension Laparoscopic Versus Open Surgery for Gallbladder Carcinoma
Status: UNKNOWN
Conditions: Gallbladder Cancer|Surgery
Interventions: PROCEDURE: Three dimensional laparoscopic|PROCEDURE: Open
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of Allograft Versus Tenting Technique in Open Sinus Lifting With Immediate Implant Placement
Status: NOT_YET_RECRUITING
Conditions: Sinus; Dental|Implant Complication|Surgery-Complications
Interventions: PROCEDURE: Sinus lifting with allograft|OTHER: Sinus lifting without graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ilaprazole for the Treatment of Duodenal Ulcer in Chinese Patients (Phase 3)
Status: COMPLETED
Conditions: Duodenal Ulcer
Interventions: DRUG: 10 mg ilaprazole|DRUG: 20 mg omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ph I:Bevacizumab + Chemotherapy in Pts w/Malig Pleural Effusion Due to Adv NSCLC
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: bevacizumab with chemotherapy, Pleur-XTM catheter placement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Cervical Interlaminar Epidural Steroid Injection on Quality of Life, Pain and Disability
Status: UNKNOWN
Conditions: Cervical Disc Herniation|Pain, Neuropathic
Interventions: DRUG: Combination Product: triamcinolone and saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMPROVE-IT: Examining Outcomes in Subjects With Acute Coronary Syndrome: Vytorin (Ezetimibe/Simvastatin) vs Simvastatin (P04103)
Status: COMPLETED
Conditions: Hypercholesterolemia|Myocardial Infarction
Interventions: DRUG: ezetimibe/simvastatin|DRUG: simvastatin|DRUG: Placebo for simvastatin 40 mg|DRUG: Placebo for ezetimibe 10 mg/simvastatin 40 mg combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of HRXG-K-1939 and Adebrelimab in Patients With Advanced Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: HRXG-K-1939|DRUG: Adebrelimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability, Pharmacokinetic, and Pharmacodynamic Study of ALXN1910 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ALXN1910|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Pharmacokinetics Study in VLBW Neonates With BSYX-A110
Status: COMPLETED
Conditions: Neonatal Staphylococcal Sepsis
Interventions: DRUG: Pagibaximab (formerly BSYX-A110)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study to Evaluate the Efficacy and Safety of MIN-102 (IMP) in Male AMN Patients.
Status: ACTIVE_NOT_RECRUITING
Conditions: Adrenoleukodystrophy
Interventions: DRUG: MIN-102|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of the Application of a Hyper-oxygenated Gel After Oral Surgery
Status: RECRUITING
Conditions: Molar, Fourth|Extracting Own Teeth|Edema Face|Pain|Trismus
Interventions: OTHER: Hyper-oxygenated gel|OTHER: glycerin based gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Ascending Dose and Dose Frequency Study of rhHNS Via an IDDD in MPS IIIA Patients
Status: COMPLETED
Conditions: Mucopolysaccharidosis (MPS)
Interventions: BIOLOGICAL: Recombinant human heparan N-sulfatase (rhHNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CRIZENT: Crizotinib and Sunitinib in Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Crixotinib 200 mg and Sunitinib Cohort 1|DRUG: Crixotinib 250 mg and Sunitinib Cohort 2|DRUG: Crizotinib & Sunitinib 37.5 mg Cohort 3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GOT Applied as Neoadjuvant Regimen for Patients of Resectable ICC With High-risk Factors of Recurrence
Status: RECRUITING
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: DRUG: Tislelizumab combined with GEMOX (GOT) regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab and Multi-fraction Stereotactic Radiosurgery With or Without Ipilimumab in Treating Patients With Recurrent Grade II-III Meningioma
Status: RECRUITING
Conditions: Grade 2 Meningioma|Grade 3 Meningioma|Recurrent Meningioma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Echocardiography|BIOLOGICAL: Ipilimumab|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Nivolumab|RADIATION: Stereotactic Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Oral Probiotic Supplementation on Group B Strep (GBS) Rectovaginal Colonization in Pregnancy
Status: COMPLETED
Conditions: Infection|Pregnancy
Interventions: DRUG: Placebo|DIETARY_SUPPLEMENT: Probiotic dietary supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: First in Man Study With SLV342
Status: TERMINATED
Conditions: Pharmacokinetics
Interventions: DRUG: SLV342|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Prosthetic Mesh in Preventing Parastomal Hernias
Status: UNKNOWN
Conditions: Parastomal Hernia
Interventions: DEVICE: Definitive end colostomy with mesh|OTHER: Conventional definitive end colostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: High Protein Formula on Enteral Feeding in Clinical Improvement and Malnutrition at Intensive Care Unit Patients
Status: COMPLETED
Conditions: Critically Ill|Intensive Care Unit
Interventions: OTHER: High Protein Polymeric Formula|OTHER: Oligomeric Formula|DRUG: 5% Dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Exercise on Functional Ability in People With Dementia in Nursing Homes:a Cluster Randomised Controlled Trial
Status: COMPLETED
Conditions: Alzheimer Disease|Dementia
Interventions: OTHER: Exercise|OTHER: Social Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hepatitis C in a Cohort of Patients With Maintenance Therapy for Opiate Dependence - Prevalence, Severity and Outcome of Antiviral Therapy
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Pegylated interferon-alfa-2b and ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of EX103 in Subjects With Relapsed/Refractory CD20-Positive Non-Hodgkin Lymphoma
Status: RECRUITING
Conditions: CD20-positive Non-Hodgkin Lymphoma
Interventions: DRUG: EX103 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repetitive Behavior Disorders in People With Severe Mental Retardation
Status: UNKNOWN
Conditions: Mental Retardation|Stereotyped Behavior|Self-Injurious Behavior|Compulsive Behavior
Interventions: DRUG: sertraline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Phase 3b Study to Assess the Efficacy, Safety, and Tolerability of Remibrutinib in Comparison to Placebo, With Omalizumab as Active Control, in Adult CSU Patients, Followed by an Open-label 52-week Optional Extension.
Status: RECRUITING
Conditions: Chronic Spontaneous Urticaria
Interventions: DRUG: Remibrutinib|DRUG: Placebo to remibrutinib|DRUG: Placebo to omalizumab|DRUG: Omalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Removal Versus Non Removal of Ceserean Section Scar .
Status: UNKNOWN
Conditions: Cesarean Wound; Dehiscence
Interventions: PROCEDURE: removal of ceserean section scar|PROCEDURE: non removal of cesearean section scar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Abraxane With Bevacizumab Biosimilar in Patients With Recurrent, Platinum-resistant Epithelial Ovarian Cancer
Status: RECRUITING
Conditions: Objective Response Rate
Interventions: DRUG: albumin-bound paclitaxe combined with bevacizumab biosimilar
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Target Dosing of Docetaxel Through Pharmacokinetic/Pharmacodynamic Optimisation of the First Chemotherapeutic Cycle
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Docetaxel (Taxotere®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of APH-1105 in Patients With Mild to Moderate Alzheimer's Disease
Status: NOT_YET_RECRUITING
Conditions: Dementia|Alzheimer Disease 1|Alzheimer Disease 2|Alzheimer Disease 3
Interventions: DRUG: APH-1105|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Model of Online Remote Interventions for Cancer-Related Cognitive Impairment
Status: COMPLETED
Conditions: Cognitive Decline|Cancer
Interventions: BEHAVIORAL: Cognitive orientation to daily occupational performance (CO-OP)|BEHAVIORAL: Computerized Cognitive Training (BrainHQ, posit science)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Safety of Combined Dosing With Aminophylline and Ambrisentan in Exercising Healthy Human Volunteers at Simulated High Altitude
Status: COMPLETED
Conditions: Acute Mountain Sickness and Fatigue
Interventions: DRUG: Aminophylline 400 mg|DRUG: Ambrisentan 5 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ARTDIVA Study : First in Man Safety Evaluation of the ART18Z Bioresorbable Stent
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: ART18Z Bioresorbable stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Acute Lymphoblastic Leukemia (ALL) in Younger Adults
Status: COMPLETED
Conditions: Leukemia, Lymphocytic
Interventions: DRUG: Rituximab|DRUG: Imatinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Encobini in BRAFV600 Mutant Stage III (B/C/D) or Oligometastatic Stage IV Melanoma
Status: UNKNOWN
Conditions: Melanoma|Cancer
Interventions: DRUG: Encorafenib + Binimetinib|DRUG: Standard Adjuvant Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Pre-pregnancy Micronutrient Supplementation on Maternal and Child Outcomes
Status: COMPLETED
Conditions: Anemia|Intrauterine Growth Retardation|Preterm Delivery|Iron Deficiency
Interventions: DIETARY_SUPPLEMENT: Multiple Micronutrient|DIETARY_SUPPLEMENT: Iron and Folic Acid|DIETARY_SUPPLEMENT: Folic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Protectivity and Safety Following Recombinant Hepatitis B Vaccine
Status: COMPLETED
Conditions: Immunogenicity
Interventions: BIOLOGICAL: Recombinant Hepatitis B vaccine|BIOLOGICAL: Recombinant Hepatitis B (Bio Farma)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Total Intravenous Anesthesia: TCI Versus MCI
Status: COMPLETED
Conditions: Test the Differences Between Schinder's TCI Model and MCI
Interventions: DEVICE: Remifentanil and propofol administration using TCI|DEVICE: Remifentanil and propofol administration using MCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Oral Testosterone Undecanoate (TU) in Hypogonadal Men
Status: COMPLETED
Conditions: Hypogonadism
Interventions: DRUG: Oral Testosterone Undecanoate|DRUG: Axiron Testosterone Topical Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Cord Injuries|Traumatic Brain Injury|Spina Bifida|Cerebral Palsy|Stroke|Parkinson Disease|Multiple Sclerosis
Interventions: OTHER: eM2M
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Camrelizumab Combined With Apatinib Mesylate and TACE in the Perioperative Treatment of Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Immunotherapy|Preoperative
Interventions: DRUG: Camrelizumab|DRUG: Apatinib Mesylate|PROCEDURE: Postoperative TACE treatment|PROCEDURE: Radical surgery|PROCEDURE: Preoperative TACE treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Adenotonsillectomy on Quality of Life in Children With Mild Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: PROCEDURE: Adenotonsillectomy|OTHER: Observation alone / no intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT