pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Studying Gene Expression in Samples From Patients With Rhabdoid Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Kidney Cancer
Interventions: GENETIC: DNA analysis|GENETIC: gene expression analysis|GENETIC: mutation analysis|GENETIC: protein expression analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Changes in Striatal [11C]ORM-13070 Binding Elicited by Changing Levels of Endogenous Noradrenaline
Status: COMPLETED
Conditions: Changes in Striatal [11C]ORM-13070 Binding.
Interventions: DRUG: Ketamine|DRUG: Atomoxetine|OTHER: Cold pressor test|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Clinical Study to Assess the Effect of Food and Gender on the Pharmacokinetics of SRT2104 Administered as an Oral Suspension or Capsule Formulation to Normal Healthy Volunteers
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: 0.5g SRT2104
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prospective Observational Study of Febrile Neutropenia (FN) and Pegfilgrastim Primary Prophylaxis in Breast Cancer and Non-Hodgkin's Lymphoma Patients Receiving High (>20%) FN-risk Chemotherapy
Status: COMPLETED
Conditions: Chemotherapy-induced Febrile Neutropenia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CKD-346 DDI Study(Telmisartan/S-Amlodipine, Rosuvastatin)
Status: COMPLETED
Conditions: Hypertension|Hyperlipidemia
Interventions: DRUG: Telmisartan/S-Amlodipine|DRUG: Rosuvastatin|DRUG: Telmisartan/S-Amlodipine + Rosuvastatin|DRUG: Telmisartan/S-Amlodipine + Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diazoxide Choline in Hypertriglyceridemia
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DRUG: Diazoxide choline|DRUG: Diazoxide choline|DRUG: Diazoxide choline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Tolerability, Maximum Tolerated Dose (MTD), Efficacy, and Pharmacokinetics (PKs) of CPI-613 Given Twice Weekly for Three Consecutive Weeks in Patients With Advanced Hematologic Malignancies
Status: COMPLETED
Conditions: Advanced Hematologic Malignancies
Interventions: DRUG: CPI-613
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy Study of Combination of Tramadol and Acetaminophen Tablets in the Treatment of Participants With Fibromyalgia Pain
Status: COMPLETED
Conditions: Pain|Fibromyalgia
Interventions: DRUG: Tramadol hydrochloride|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Xenon MRI and Progressive ILD
Status: RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis|Progressive Pulmonary Fibrosis
Interventions: DRUG: Hyperpolarized 129 Xenon Gas Comparing Progressive Pulmonary Fibrosis Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of the Immunogenicity and Safety of SCTV01C in Population Aged ≥12 Years and Previously Vaccinated With Inactivated COVID-19 Vaccine
Status: WITHDRAWN
Conditions: COVID-19|SARS-CoV2 Infection
Interventions: BIOLOGICAL: SCTV01C|BIOLOGICAL: Comirnaty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of Asacol (Mesalazine) Suppository on the Treatment of Diarrhea-Induced Acute Fissure
Status: COMPLETED
Conditions: Fissure in Ano|Diarrhea
Interventions: DRUG: Asacol is used to treat and prevent mild to moderate acute fissure disease
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Comparison Of Dexmedetomidine And Dexamethasone As An Adjuvant To Bupivacaine In Brachial Plexus Block
Status: COMPLETED
Conditions: Brachial Plexus Block|Dexmedetomidine|Dexamethasone|Bupivacaine
Interventions: PROCEDURE: adding Dexmedetomidine and dexamethasone to bupivacaine in USG guided supraclavicular brachial plexus block.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Endoscopic Sleeve Gastrectomy (ESG) Trial (MERIT Trial)
Status: COMPLETED
Conditions: Obesity|Hypertension|Diabetes Mellitus, Type 2
Interventions: DEVICE: Overstitch Endoscopic Suture System|BEHAVIORAL: Lifestyle Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Trabectedin First Line Therapy In Unfit Sarcoma Study
Status: COMPLETED
Conditions: Metastatic and Locally Advanced Soft Tissue Tumor Patients Unfit to Receive|Standard Chemotherapy
Interventions: DRUG: Trabectedin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Codeine Phosphate/Guaifenesin ER Tablet 30 mg/600 mg Steady State Clinical Study
Status: COMPLETED
Conditions: Cough
Interventions: DRUG: Codeine Phosphate/Guaifenesin ER Tablet|DRUG: Codeine Phosphate/Guaifenesin IR Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Thyme Honey as a Novel Adjunct to Non-surgical Periodontal Therapy
Status: NOT_YET_RECRUITING
Conditions: Periodontal Diseases
Interventions: OTHER: Thyme honey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial
Status: RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: Empagliflozin + Potassium Chloride|DRUG: Empagliflozin + Potassium Nitrate|DRUG: Potassium Chloride + Placebo for Empagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: (Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis
Status: RECRUITING
Conditions: Advanced Systemic Mastocytosis (AdvSM)|SM With an Associated Hematologic Neoplasm (SM-AHN)|Mast Cell Leukemia (MCL)|Aggressive Systemic Mastocytosis (ASM)
Interventions: DRUG: bezuclastinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tarceva (Erlotinib) in Sequential Combination With Gemcitabine as First Line Therapy in Patients With Advanced Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: erlotinib [Tarceva]|DRUG: gemcitabine|DRUG: gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dysregulation of FSH in Obesity: Functional and Statistical Analysis
Status: COMPLETED
Conditions: Obesity|Fertility
Interventions: DRUG: Degarelix (GnRH antagonist)|DRUG: recombinant FSH|DRUG: Cetrorelix
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Myocardial Stress Perfusion Computed Tomography in the Evaluation of Patients With Acute Chest Pain Using a Novel 3rd Generation Dual-source CT System
Status: TERMINATED
Conditions: Chest Pain
Interventions: DEVICE: Somatom Force CT Scanner
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Premature Gut Microbiome and the Influence on Neonatal Immunity, Brain Development and White Matter Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Microbiome|Neurodevelopment Outcome|Immunology
Interventions: OTHER: Microbiome Sequencing, Neurophysiologic Assessment, Immunological test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparing Intra-articular Betamethasone (Diprospan) and Triamcinolone Acetonide Injection in Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: Betamethasone Dipropionate / Betamethasone Sodium Phosphate|DRUG: Triamcinolone Acetonide 40mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Oral Upadacitinib Tablets to Assess Change in Disease State in Participants Aged 12-75 Years With Moderate to Severe Atopic Dermatitis in Brazil
Status: WITHDRAWN
Conditions: Atopic Dermatitis (AD)
Interventions: DRUG: Upadacitinib|DRUG: Placebo for Upadacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Goal Directed Fluid Therapy in Enhanced Recovery After Surgery in Gastro-intestinal Oncosurgeries
Status: COMPLETED
Conditions: Fluid Loss|Enhanced Recovery
Interventions: PROCEDURE: Goal directed Fluid Therapy|PROCEDURE: Conventional Fluid Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cryotherapy in the Prevention of Chemotherapy-Induced Mucositis in Stem Cell Transplant
Status: TERMINATED
Conditions: Mucositis|Hematopoietic Stem Cell Transplantation|Peripheral Blood Stem Cell Transplantation|Stomatitis
Interventions: OTHER: Ice|OTHER: Normal Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Performance-Enhancing Effects of Platelet-Rich Plasma (PRP) Injections
Status: COMPLETED
Conditions: Tendinopathy|Rheumatic Diseases
Interventions: PROCEDURE: Ultrasound-guided platelet-rich-plasma (PRP) injection|PROCEDURE: Platelet-Rich Plasma (PRP)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: UCon Treatment of Overactive Bladder (OAB) in Males
Status: RECRUITING
Conditions: Urinary Incontinence|Urge Incontinence|Nocturia|Urinary Frequency More Than Once at Night|Urinary Incontinence, Urge|Incontinence, Nighttime Urinary
Interventions: DEVICE: Urge stimulation|DEVICE: Time limited stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterizing Hypoxic Apnea Intra-individual Repeatability
Status: COMPLETED
Conditions: Hypoxia|Apnea
Interventions: OTHER: Apnea Following Isocapnic Hypoxia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of L-arginine on Myocardial Energetic Efficiency and Global Longitudinal Strain
Status: COMPLETED
Conditions: Myocardial Dysfunction
Interventions: DRUG: Bioarginine|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity, Efficacy and Safety Study of an MSP3-LSP (Long Synthetic Peptide) Malaria Vaccine
Status: UNKNOWN
Conditions: Malaria
Interventions: BIOLOGICAL: MSP3 Long Synthetic Peptide 30 micrograms of MSP3 LSP|BIOLOGICAL: Verorab vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Analgesic Effect of Esketamine in DCSB in Adultscontrolled Study
Status: NOT_YET_RECRUITING
Conditions: Analgesia|Burns
Interventions: DRUG: Esketamine 0.1mg/kg intravenous injection|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Preoperative Gabapentin Versus Pregabalin on Shoulder Pain After Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Pain, Postoperative|Cholecystectomy, Laparoscopic
Interventions: DRUG: Pregabalin 75mg|DRUG: Gabapentin 300mg|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Nephrotoxicity Associated to Parenchymal Clamping During Partial Nephrectomy Using a Microdialysis Technique
Status: TERMINATED
Conditions: Nephrectomy|Kidney Cancer|Microdialysis
Interventions: PROCEDURE: Renal microdialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Study of mRNA Vaccine in Patients With Advanced Malignant Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced Malignant Solid Tumors
Interventions: BIOLOGICAL: Neoantigen mRNA Personalised Cancer vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Newer Antidepressants in Combination With Pregabalin for Fibromyalgia Syndrome
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: Amitriptyline|DRUG: Venlafaxine|DRUG: Paroxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brain Computer Interface (BCI) Technology for Stroke Hand Rehabilitation
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Occupational Therapy|DEVICE: BCI Haptic Knob|DEVICE: Haptic Knob
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Bevacizumab in Treating Patients With Metastatic Breast Cancer That Overexpresses HER-2/NEU
Status: TERMINATED
Conditions: Breast Carcinoma|Recurrent Breast Carcinoma|Stage IV Breast Cancer
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Carboplatin|DRUG: Paclitaxel|OTHER: Placebo|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Segmental Examination Twice of the Proximal Colon on Adenoma Detection
Status: COMPLETED
Conditions: Colonic Polyps
Interventions: PROCEDURE: Extending withdrawal time in the proximal colon|PROCEDURE: Segmental examination twice of the proximal colon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Blood Pressure Reduction in Heart Failure
Status: COMPLETED
Conditions: Heart Failure|Cardiac Failure|Congestive Heart Failure
Interventions: DRUG: Hydralazine/amlodipine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: VIdeo Assisted Thoracoscopic Lobectomy Versus Conventional Open LobEcTomy for Lung Cancer
Status: COMPLETED
Conditions: Lung Neoplasms
Interventions: PROCEDURE: Open Surgery|PROCEDURE: Video Assisted Thoracoscopic Surgery (VATS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Relapsed/Refractory Advanced Solid Tumors
Status: RECRUITING
Conditions: Lung Cancer|Bronchial Cancer|Non Small Cell Lung Cancer|Small Cell Lung Cancer|Sarcoma|Colorectal Cancer|Gastric Cancer|Liver Cancer|Breast Cancer|Pancreatic Cancer|Head and Neck Cancer|Ovarian Cancer
Interventions: DRUG: Recombinant oncolytic herpes simplex virus type 1 (R130)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HT-ENDO: A Multiomics-based Biomarker for the Diagnosis of Endocrine Hypertension: a Pragmatic, Diagnostic, Randomized, Outcome-based Trial
Status: NOT_YET_RECRUITING
Conditions: Hypertension
Interventions: DIAGNOSTIC_TEST: HT-ENDO-MOS-A13|OTHER: Normal diagnosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mobile Smoking Treatment for Spanish-speaking Latinx Smokers
Status: UNKNOWN
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Impacto (Mobile App)|BEHAVIORAL: Dejar de Fumar Asistente (Mobile App)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ablation of Paroxysmal Atrial Fibrillation Using the Appropriate Contact Force in a Chinese Population
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: BEHAVIORAL: The operator blinded to the contact force data or not.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Atezolizumab in Treating Patients With Cancer Following Adoptive Cell Transfer
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Metastatic Malignant Solid Neoplasm|Unresectable Malignant Solid Neoplasm
Interventions: DRUG: Atezolizumab|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Red Yeast Rice and Phytosterols In Statin Intolerance
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DIETARY_SUPPLEMENT: red yeast rice|DRUG: phytosterol|BEHAVIORAL: therapeutic lifestyle program|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Describe the Safety and Immunogenicity of a Respiratory Syncytial Virus Vaccine STR-V003 in Healthy Adults
Status: NOT_YET_RECRUITING
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: STR-V003/Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Modified Otago Versus Action Observation on Strength, Mobility and Fall Risk in Diabetic Neuropathy
Status: RECRUITING
Conditions: Diabetic Neuropathies|Mobility|Fall
Interventions: OTHER: modified otago exercises|OTHER: Action Observation Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VA CoronavirUs Research and Efficacy Studies-1
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Convalescent Plasma|OTHER: Masked Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn How BAY2927088 is Taken up and Handled by the Body in Healthy Male Participants
Status: COMPLETED
Conditions: Advanced Non-small Cell Lung Cancer|EGFR Mutation|HER2 Mutation|Healthy Volunteers
Interventions: DRUG: BAY2927088 coated tablet 10 mg|DRUG: [14C]-BAY2927088 solution for infusion|DRUG: [14C]-BAY2927088 oral solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Development and Evaluation of Hygie, a New Serious Game for Continuing Medical Education of General Practitioners
Status: COMPLETED
Conditions: CONTINUING MEDICAL EDUCATION
Interventions: DEVICE: Hygie|DEVICE: Source articles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Sleep in Late Pregnancy - Artificial Intelligence Development for the Detection of Disturbances and Disorders
Status: RECRUITING
Conditions: Pregnancy Related|Sleep|Sleep-Disordered Breathing|Sleep Disturbance|Sleep Disorder
Interventions: DEVICE: Infrared video-audio camera|DEVICE: Level III home sleep apnea test|DEVICE: Maternal-fetal transabdominal electrocardiographic heart rate monitor|DEVICE: Pressure sensing mat
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Association of Microbiota Composition With cGVHD After Allo-HSCT
Status: RECRUITING
Conditions: Hematopoietic Stem Cell Transplantation|Hematologic Malignancy|Chronic Graft-versus-host-disease|Complication
Interventions: OTHER: blood sample|OTHER: stool sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: VAL-083 Phase 3 Study in Temozolomide-Avastin (Bevacizumab) Recurrent GBM
Status: TERMINATED
Conditions: Glioblastoma Multiforme|Glioblastoma|Glioma|GBM|Brain Cancer
Interventions: DRUG: VAL-083, Dianhydrogalactitol|DRUG: Physician's Choice of Salvage Therapy - temozolomide|DRUG: Physician's Choice of Salvage Therapy - lomustine|DRUG: Physician's Choice of Salvage Therapy - carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Bioavailability of Pterostilbene Cocrystal Compared to Its Free Form (BIOPTERO)
Status: COMPLETED
Conditions: Biological Availability
Interventions: DIETARY_SUPPLEMENT: Pterostilbene cocrystal|DIETARY_SUPPLEMENT: Pterostilbene free form
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Fecal Microbiota Transplantation for the Treatment of Primary Sclerosing Cholangitis.
Status: COMPLETED
Conditions: Sclerosing Cholangitis
Interventions: BIOLOGICAL: Fecal Microbiota Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety, Tolerability, PK, and PD of XW003 Injection in Healthy Adult Participants
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Obesity|Nonalcoholic Steatohepatitis
Interventions: DRUG: Cohort A|DRUG: Placebo A|DRUG: Cohort B|DRUG: Placebo B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid in Vaginal Reconstructive Surgery
Status: NOT_YET_RECRUITING
Conditions: Pelvic Organ Prolapse
Interventions: DRUG: Tranexamic acid|DRUG: Vasopressin|OTHER: NaCl 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cyclophosphamide Plus Vaccine Therapy in Treating Patients With Advanced Cancer
Status: COMPLETED
Conditions: Breast Cancer|Colorectal Cancer|Kidney Cancer|Lung Cancer|Malignant Mesothelioma|Pancreatic Cancer
Interventions: BIOLOGICAL: allogeneic tumor cell vaccine|BIOLOGICAL: autologous tumor cell vaccine|BIOLOGICAL: recombinant interferon alfa|BIOLOGICAL: recombinant interferon gamma|BIOLOGICAL: sargramostim|DRUG: cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Latanoprost Preserved Versus Unpreserved: Effect on Tear Film Thickness as Measured With OCT
Status: UNKNOWN
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: Preservative-free latanoprost 50µg/ml|DRUG: Preserved latanoprost 0.005%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study on Prevention of SARS-CoV-2 Transmission During a Large Indoor Gathering Event
Status: COMPLETED
Conditions: Covid19
Interventions: OTHER: Concert|DIAGNOSTIC_TEST: Rapid nasopharyngeal antigen test for Sars-Cov-2|DIAGNOSTIC_TEST: Saliva Sample
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Multi-channel Stimulation for Post Stroke Spasticity (MUSTS)
Status: COMPLETED
Conditions: Muscle Spasticity|Stroke
Interventions: DEVICE: ShefStim|DEVICE: Electrodes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dual-Tracer Theranostic PET
Status: COMPLETED
Conditions: Neuroendocrine Tumors|Prostate Cancer
Interventions: DIAGNOSTIC_TEST: Single-Tracer FDG PET/CT Exam|DIAGNOSTIC_TEST: Single-Tracer Cu64-DOTATATE PET/CT Exam|DIAGNOSTIC_TEST: Single-Tracer Ga68-DOTATATE PET/CT Exam|DIAGNOSTIC_TEST: Single-Tracer PSMA PET/CT Exam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Randomized, Single Center Pilot Study Comparing Hyaluronic Acid to Vaginal Estrogen for Treatment of Genitourinary Syndrome of Menopause
Status: COMPLETED
Conditions: Genitourinary Syndrome of Menopause (GSM)
Interventions: DEVICE: Revaree|DRUG: Estrace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ESTxENDS Trial-Substudy on Oxidative Stress Induced by Electronic Nicotine Delivery Systems (ENDS) Measured in Urine
Status: COMPLETED
Conditions: Smoking Cessation|Oxidative Stress
Interventions: OTHER: ENDS (vaporizer/e-cig) and smoking cessation counseling|OTHER: smoking cessation counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Two-year Study of Telbivudine in HBeAg Negative Hepatitis
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Telbivudine, Adefovir dipivoxil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Staccato Loxapine Pulmonary Safety in Patients With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Inhaled loxapine @ 0 & 10 h|DRUG: Inhaled placebo @ 2 & 10 hours
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NIV Prevents Post-operative Respiratory Failure After Bariatric Surgery
Status: COMPLETED
Conditions: Obesity|Postoperative Respiratory Distress
Interventions: DEVICE: Non invasive ventilation (NIV)|DEVICE: Conventional Venturi Mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Teen CHAT: Improving Physician Communication With Adolescents About Healthy Weight
Status: COMPLETED
Conditions: Communication|Obesity|Nutrition|Physical Activity|Sleep
Interventions: BEHAVIORAL: Web-based intervention targeting MD communication; Summary Report
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Assessment of Women's Sexual Quality of Life After Benign Adnexal Surgery Using vNOTES Approach
Status: NOT_YET_RECRUITING
Conditions: Gynecologic Disease|Adnexal Mass|Adnexal Cyst|Sexuality|Adnexal Diseases|Sexual Dysfunction|Quality of Life|Pathology|Dyspareunia|Pelvic Pain|Complication
Interventions: PROCEDURE: Elective cystectomy|PROCEDURE: Elective oophorectomy|PROCEDURE: Elective salpingectomy|PROCEDURE: Elective tubal sterilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Effects and Safety of Idarubicin-strengthened Pretreatment Program and Conventional Busulfan Cyclophosphamide Pretreatment Program on High-risk Acute Myeloid Leukemia Patient
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Cyclosporin A,mycophenolate mofetil,Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Bioavailability of Vitamin D2 in Yeast and Bread
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Consumption of capsule/bread with vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mesh Stents Study in ILIAC Complex Lesions (IMS-Study)
Status: NOT_YET_RECRUITING
Conditions: Peripheral Arterial Disease|Iliac Artery Stenosis|Embolus Arterial|Ischemic Leg
Interventions: DEVICE: Iliac Stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Endoscopic Stenting and Cholecystojejunostomy for PreoperativeDrainage Before Pancreaticoduodenectomy
Status: WITHDRAWN
Conditions: Periampullary Cancer|Pancreatic Cancer
Interventions: PROCEDURE: Endoscopic stenting|PROCEDURE: cholecystojejunostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebral Oxygenation and Metabolism After Reversal Of Rocuronium: Comparison Between Sugammadex Versus Neostigmine
Status: UNKNOWN
Conditions: Supratentorial Brain Tumor Surgery
Interventions: DRUG: Sugammadex|DRUG: Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neuromuscular Control in Individuals Following ACL-Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injuries|Quadriceps Muscle Atrophy
Interventions: OTHER: Visuomotor Therapy|OTHER: Passive Motion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cabergoline Versus GnRH Antagonist Rescue and Cabergoline in the Prevention of Ovarian Hyperstimulation Syndrome
Status: UNKNOWN
Conditions: OHSS
Interventions: DRUG: Cabergoline|DRUG: GnRH antagonist rescue & cabergoline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Immunological Responses After SARS-CoV-2 Infection Causing COVID-19
Status: ENROLLING_BY_INVITATION
Conditions: Covid19|SARS-CoV2 Infection|Olfactory Disorder|COVID-19|Smell Loss|Smell Disorder
Interventions: DIAGNOSTIC_TEST: COVID-19 antibody test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Two Stress Management Programs in Adaptation Disorder With Anxiety (ADA)
Status: COMPLETED
Conditions: Adjustment Disorders|Psychological Stress
Interventions: BEHAVIORAL: Computer-based stress management program|BEHAVIORAL: Stress management in face-to-face|OTHER: Waiting list
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: REPAIR-AMI: Intracoronary Progenitor Cells in Acute Myocardial Infarction (AMI)
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: BIOLOGICAL: Intracoronary infusion of enriched bone marrow-derived progenitor cells|BIOLOGICAL: Placebo medium supplemented with autologous serum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Precise Diagnosis and Intervention of CPT Based on a Noninvasive 3D-vHPS
Status: UNKNOWN
Conditions: Portal Hypertension|Cirrhosis
Interventions: DRUG: Carvedilol|DEVICE: 3D-vHPS|PROCEDURE: Routine endoscopic procedures
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ultrasound-guided Lumbar Periradicular Injection: a Non Irradiating Infiltration Technique
Status: UNKNOWN
Conditions: Low Back Pain|Sciatica|Disc, Herniated|Foraminal Hernia|Lumbar Foraminal Stenosis|Chronic Low Back Pain|Pain, Chronic|Injection Site Infiltration
Interventions: DEVICE: Ultrasound guided periradicular lumbar infiltration|DEVICE: Fluoroscopy guided periradicular lumbar infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiologic Cardiac Pacing to Prevent Left Ventricular Dysfunction Post TAVI
Status: NOT_YET_RECRUITING
Conditions: Atrioventricular Block, Second and Third Degree
Interventions: DEVICE: conduction system pacing|DEVICE: right ventricular or biventricular pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Anesthesia for Catheter Aortic Valve ImplantATIOn Registry
Status: RECRUITING
Conditions: Heart Failure|Excessive Amount of Blood / Fluid Transfusion|Intraoperative Cardiac Arrest During Cardiac Surgery|Critical Incident|Anesthesia|Failed Conscious Sedation During Procedure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Pitt Retiree Study: A Diabetes Prevention Program for Medicare Eligible Older Adults
Status: COMPLETED
Conditions: Obesity|Cardiovascular Risk Factor|Eating Behavior|Diet Modification|Physical Activity|Quality of Life|Mobility Limitation
Interventions: BEHAVIORAL: GLB plus phone contacts|BEHAVIORAL: GLB plus newsletter contacts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vegetable Proteins Versus Mixed Animal Proteins on the Outcome of Hepatic Encephalopathy
Status: NOT_YET_RECRUITING
Conditions: Hepatic Encephalopathy
Interventions: DIETARY_SUPPLEMENT: mixed animal and vegetable proteins|DIETARY_SUPPLEMENT: pure vegetable proteins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Pertuzumab With Erlotinib in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Erlotinib|DRUG: Pertuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-Testing Options in the Era of Primary HPV Screening for Cervical Cancer Trial
Status: COMPLETED
Conditions: Uterine Cervical Neoplasm|Uterine Neoplasms|Genital Neoplasms, Female|Urogenital Neoplasms|Neoplasms by Site|Neoplasms|Uterine Cervical Diseases|Uterine Diseases|Cervical Cancer|Cervical Dysplasia|Human Papilloma Virus|HPV-Related Cervical Carcinoma|HPV Infection|HPV-Related Malignancy
Interventions: OTHER: Usual Care|BEHAVIORAL: Education|BEHAVIORAL: Direct Mail|BEHAVIORAL: Opt-in
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Recombinant Interferon Alfa-2b in Treating Patients With Melanoma
Status: COMPLETED
Conditions: Stage IA Skin Melanoma|Stage IB Skin Melanoma|Stage IIA Skin Melanoma|Stage IIB Skin Melanoma|Stage IIC Skin Melanoma|Stage IIIA Skin Melanoma|Stage IIIB Skin Melanoma|Stage IIIC Skin Melanoma|Stage IV Skin Melanoma
Interventions: BIOLOGICAL: recombinant interferon alfa-2b|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of 3D Printing Guide Plate in Dorsal Root Ganglion Intervention Treatments
Status: UNKNOWN
Conditions: Lumbar Disc Herniation|Lumbar Spinal Stenosis
Interventions: OTHER: 3D printing guide plate|OTHER: Conventional guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pyrotinib Plus Vinorelbine in Participants With HER2-positive Previously Treated Locally Advanced or Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer|Pyrotinib|Breast Diseases|Vinorelbine|HER2-positive Breast Cancer
Interventions: DRUG: Pyrotinib 320mg + Vinorelbine|DRUG: Pyrotinib 400mg + Vinorelbine|DRUG: Pyrotinib plus Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Effectiveness and Safety of ULTRACET® (Tramadol HCl/Acetaminophen) Versus Placebo for the Treatment of Acute Pain From a Migraine Headache
Status: COMPLETED
Conditions: Migraine|Head Pain|Headache
Interventions: DRUG: tramadol HCl/acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficiency Study of Clarithromycin and Bismuth-containing Quadruple Therapy to Treat H.Pylori
Status: COMPLETED
Conditions: Functional Dyspepsia|Peptic Ulcer|Helicobacter Pylori
Interventions: DRUG: Esomeprazole|DRUG: Amoxicillin|DRUG: Clarithromycin|DRUG: Bismuth Potassium Citrate|OTHER: long duration (14 day)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Foster With or Without Charcoal Block or Aerochamber Plus
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: PROCEDURE: charcoal block|DEVICE: Aerochamber Plus spacer|DRUG: pMDI standard actuator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy and Safety Comparative Study Between CMAB807 Injection and Prolia® .
Status: RECRUITING
Conditions: Postmenopausal Osteoporosis
Interventions: DRUG: CMAB807 Injection|DRUG: Prolia®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Daratumumab in Treating Participants With Relapsed Multiple Myeloma After Stem Cell Transplant
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Plasma Cell Myeloma
Interventions: BIOLOGICAL: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NeoMatriX Wound Matrix Collagen Dressing Skin Prick Test
Status: COMPLETED
Conditions: Allergy Skin|Allergy|Dermatitis, Allergic Contact
Interventions: DEVICE: NeoMatriX Wound MatriX Collagen Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Risk of Intraventricular Hemorrhage With Flat Midline Versus Right-Tilted Flat Lateral Head Positions
Status: TERMINATED
Conditions: Intraventricular Hemorrhage
Interventions: OTHER: Flat midline head position|OTHER: Right flat lateral head position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Introducing a Single IV Abatacept Treatment in RA Patients Currently Receiving Weekly SC Abatacept to Simulate a Holiday
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: IV Abatacept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b/2 Study of MEDI4736 With Tremelimumab, MEDI4736 or Tremelimumab Monotherapy in Gastric or GEJ Adenocarcinoma
Status: COMPLETED
Conditions: Gastric or Gastroesophageal Junction Adenocarcinoma
Interventions: BIOLOGICAL: MEDI4736 + tremelimumab|BIOLOGICAL: MEDI4736 + tremelimumab|BIOLOGICAL: MEDI4736|BIOLOGICAL: Tremelimumab|BIOLOGICAL: MEDI4736+tremelimumab|BIOLOGICAL: MEDI4736 + tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sub-threshold Pacing to Prevent Pacemaker-induced Ventricular Tachycardia
Status: COMPLETED
Conditions: Ventricular Tachyarrhythmias|ICD Shock Therapy|ICD Shock Burden
Interventions: OTHER: Programming the pacemaker output for ventricular back-up pacing to a sub-threshold level
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating the Safety and Efficacy of Romiplostim (AMG 531) in Thrombocytopenic Subjects With Immune Thrombocytopenic Purpura (ITP)
Status: COMPLETED
Conditions: Idiopathic Thrombocytopenic Purpura
Interventions: DRUG: Romiplostim|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of WPV01 Compared With Placebo in Patients With Mild/Moderate COVID-19 Infection
Status: COMPLETED
Conditions: COVID-19 Infection
Interventions: DRUG: WPV01|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of CHF 6532 in Patients With Uncontrolled Severe Eosinophilic Asthma
Status: TERMINATED
Conditions: Asthma; Eosinophilic
Interventions: DRUG: Treatment A|DRUG: Treatment B|DRUG: Treatment C|DRUG: Treatment D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of GNiib® in Obesity Management in Obese Young Individuals in Hong Kong.
Status: UNKNOWN
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: G-Niib|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Sunitinib With Paclitaxel/Carboplatin in Patients With Triple-Negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigational Study of SHR6390 in Participants With Mild to Moderate Liver Impairment and Healthy Participants
Status: UNKNOWN
Conditions: Hepatic Impairment|Healthy Participants
Interventions: DRUG: SHR6390
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Administration of GV1001 for the Treatment of Progressive Supranuclear Palsy Who Completed Study GV1001-PSP-CL2-011
Status: RECRUITING
Conditions: Progressive Supranuclear Palsy
Interventions: DRUG: GV1001 Placebo|DRUG: GV1001 1.12mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benzocaine Gel Toothache Dose-Response Study
Status: COMPLETED
Conditions: Toothache
Interventions: DRUG: Placebo gel|DRUG: benzocaine|DRUG: benzocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gerontology Research Programme: The Singapore Longitudinal Ageing Studies (SLAS I & II)
Status: UNKNOWN
Conditions: Cognitive Changes Due to Organic Disorder (Finding)|Dementia|Mild Cognitive Impairment|Frailty|Depression|Healthy Ageing|Biological Ageing
Interventions: OTHER: SLAS 1|OTHER: SLAS 2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer
Status: RECRUITING
Conditions: Biliary Tract Cancer|HER2 Gene Mutation
Interventions: DRUG: Zanidatamab|DRUG: Cisplatin|DRUG: Gemcitabine|DRUG: Pembrolizumab|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biofeedback Treatment of Anxiety Associated With Chronic Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries|Anxiety|Stress|Tetraplegia
Interventions: BEHAVIORAL: Psychophysiological monitoring|BEHAVIORAL: Biofeedback training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing Possible Additive Effects of tDCS and Mirror Therapy Treatments for Phantom Pain
Status: UNKNOWN
Conditions: Phantom Limb Pain
Interventions: DEVICE: transcranial Direct Current Stimulation (tDCS)|OTHER: Mirror therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Conditioning Neural Circuits to Improve Upper Extremity Function
Status: COMPLETED
Conditions: Spinal Cord Injury|Tetraplegia
Interventions: OTHER: transcranial direct current stimulation|OTHER: peripheral nerve somatosensory stimulation|OTHER: sham transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT