pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Volar Internal Plate Fixation vs. Plaster in Extra- Articular Distal Radial Fractures
Status: COMPLETED
Conditions: Displaced Extra-articular Distal Radius Fractures
Interventions: PROCEDURE: open reduction and internal fixation|OTHER: Closed reduction and plaster
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OPTImization of Medication by Transdisciplinary Assessment of Drug Treatment in Elderly Hospitalized Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Multimorbidity|Polypharmacy
Interventions: OTHER: Definitive multi-faceted intervention consisting of several components|OTHER: Sham Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Hippotherapy in Patients With Schizophrenia
Status: NOT_YET_RECRUITING
Conditions: Equine-Assisted Therapy|Schizophrenia
Interventions: OTHER: Hippotherapy|OTHER: Standard psychiatric treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Songyou Granule and Transarterial Chemoembolization for Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma|Unresectable
Interventions: DRUG: Songyou|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS)
Status: RECRUITING
Conditions: Preterm Birth|Premature Birth|Complication of Prematurity|Obstetric Labor, Premature|Pregnancy Complications
Interventions: DRUG: Celestone + placebo|DRUG: Celestone + Celestone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Two Chemotherapy Regimens Plus or Minus Bevacizumab
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: LV5FU2|DRUG: Streptozocin|DRUG: Capecitabine|DRUG: Temozolomide|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antismoking Effects of Electronic Cigarettes in Subjects With Schizophrenia and Their Potential Influence on Cognitive Functioning.
Status: NOT_YET_RECRUITING
Conditions: Tobacco Smoking in Schizophrenic Patients
Interventions: DEVICE: Ecig 24 mg nicotine|DEVICE: Ecig 0 mg nicotine|DEVICE: Nicotine free inhalator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dual Bronchodilation With Umeclidinium/Vilanterol on Patients With COPD, Hyperinflation and Heart Failure
Status: RECRUITING
Conditions: Copd|Heart Failure
Interventions: DRUG: Umeclidinium/vilanterol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Nasal Mucosa Histopathological Changes in Chronic Hypersensitivity Pneumonitis
Status: COMPLETED
Conditions: Hypersensitivity Pneumonitis|Nasal Mucosal Disorder
Interventions: PROCEDURE: nasal endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Study of ET019002-T Cell Therapy for Refractory/Relapsed B-Cell Malignancies
Status: UNKNOWN
Conditions: B-Cell Malignancies
Interventions: BIOLOGICAL: Low dose ET019002- T Cells|BIOLOGICAL: Middle dose ET019002- T Cells|BIOLOGICAL: High dose ET019002- T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Needlescopic-assisted Uniportal vs Uniportal VATS
Status: COMPLETED
Conditions: Lung Cancer|Lung Cancer Metastatic|Bullous Disease Lung|Nodule Solitary Pulmonary|Mediastinal Tumor
Interventions: PROCEDURE: Thoracoscopic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Home Testing Devices for the Management of Glaucoma
Status: RECRUITING
Conditions: Glaucoma, Open-Angle
Interventions: DIAGNOSTIC_TEST: Standard Automatic Perimetry Humphrey Field Analyzer|DIAGNOSTIC_TEST: visuALL H|DIAGNOSTIC_TEST: iCare Home Tonometer|DIAGNOSTIC_TEST: Spectralis Optical coherence tomography (OCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of ASP7517 Alone and With Pembrolizumab in Participants With Advanced Solid Tumors Expressing WT1 Antigen
Status: COMPLETED
Conditions: Advanced Malignancies|Advanced Cancer
Interventions: DRUG: ASP7517|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amantadine for Improving Neurologic Symptoms in Ataxia-Telangiectasia
Status: COMPLETED
Conditions: Ataxia|Chorea|Dystonia|Parkinsonism|Fatigue
Interventions: DRUG: amantadine sulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nebulized Fluticasone Propionate VS Oral Prednisone in Chinese Pediatric and Adolescent Subjects With an Acute Exacerbation of Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: fluticasone propionate inhalation solution|DRUG: oral prednisone|DRUG: placebo inhalation solution|DRUG: placebo tablet|DRUG: salbutamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Research of Berberine Hydrochloride to Prevent Colorectal Adenomas in Patients With Previous Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Adenomas
Interventions: DRUG: Berberine hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Open-Label CA-008 (Vocacapsaicin) in Bunionectomy
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: CA-008|DRUG: Ketorolac|DRUG: Acetaminophen IV|DRUG: Fentanyl|DRUG: Bupivacaine Hydrochloride|DRUG: Lidocaine HCl|DRUG: Celecoxib|DRUG: Acetaminophen Oral|DRUG: Lidocaine Hydrochloride|DRUG: Exparel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction Optimization With Stelara for Crohn's Disease
Status: TERMINATED
Conditions: Crohn Disease
Interventions: DRUG: Ustekinumab|DRUG: Ustekinumab|DRUG: Ustekinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Prediction of Development, Progression or Complications of Kidney, Immune or Transplantation-related Diseases
Status: RECRUITING
Conditions: Acute Kidney Injury|Chronic Kidney Diseases|Solid-organ Transplantation|Cancer|Metabolic Disease|Immune Diseases
Interventions: BIOLOGICAL: Biological samples collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Fospropofol vs Propofol During Invasive Mechanical Ventilation.
Status: NOT_YET_RECRUITING
Conditions: Invasive Mechanical Ventilation
Interventions: DRUG: Fospropofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: QPI-1002 for Prevention of Delayed Graft Function in Recipients of an Older Donor Kidney Transplant
Status: COMPLETED
Conditions: Delayed Graft Function
Interventions: DRUG: QPI-1002|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cetuximab and Recombinant Interleukin-12 in Treating Patients With Squamous Cell Carcinoma of the Head and Neck That is Recurrent, Metastatic, or Cannot Be Removed by Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Head and Neck Squamous Cell Carcinoma|Recurrent Head and Neck Squamous Cell Carcinoma|Unresectable Head and Neck Squamous Cell Carcinoma
Interventions: BIOLOGICAL: Cetuximab|BIOLOGICAL: Edodekin alfa|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Golimumab (MK-8259 / SCH900259) Treatment Withdrawal in Participants With Non-radiographic Axial Spondyloarthritis (GO-BACK) (MK-8259-038)
Status: COMPLETED
Conditions: Spondyloarthritis
Interventions: BIOLOGICAL: Golimumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Directed Reduction of Colles Type Distal Radial Fractures in ED (UDiReCT)
Status: COMPLETED
Conditions: Radius Distal Fracture|Colles' Fracture
Interventions: PROCEDURE: MUA with sham ultrasound|PROCEDURE: MUA with active ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of GS-9450 Treatment for 6 Months in Patients With Chronic Hepatitis C Virus Infection
Status: TERMINATED
Conditions: HCV Infection
Interventions: DRUG: GS-9450|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Biomarkers on Pharmacokinetics and Pharmacodynamics of Direct Oral Anticoagulants
Status: UNKNOWN
Conditions: Novel Oral Anticoagulants|NOACs|Rivaroxaban|Apixaban|Dabigatran|Pharmacokinetics|Pharmacodynamics|Pharmacogenomics|Accurate Medication
Interventions: GENETIC: detection of genotype
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Investigating the Safety, Tolerability and Efficacy of ASP7517 in Subjects With Relapsed/Refractory Acute Myeloid Leukemia (AML) and Relapsed/Refractory Higher Risk Myelodysplastic Syndrome (MDS)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome
Interventions: BIOLOGICAL: ASP7517
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Talazoparib in Treating Patients With Advanced or Metastatic Solid Tumors That Cannot Be Removed by Surgery and Liver or Kidney Dysfunction
Status: WITHDRAWN
Conditions: Estrogen Receptor Negative|Head and Neck Squamous Cell Carcinoma|HER2/Neu Negative|Hormone-Resistant Prostate Cancer|Metastatic Pancreatic Adenocarcinoma|Progesterone Receptor Negative|Solid Neoplasm|Stage III Mesothelioma|Stage IIIA Gastric Cancer|Stage IIIA Non-Small Cell Lung Cancer|Stage IIIA Ovarian Cancer|Stage IIIA Small Cell Lung Carcinoma|Stage IIIB Gastric Cancer|Stage IIIB Non-Small Cell Lung Cancer|Stage IIIB Ovarian Cancer|Stage IIIB Small Cell Lung Carcinoma|Stage IIIC Gastric Cancer|Stage IIIC Ovarian Cancer|Stage IV Mesothelioma|Stage IV Non-Small Cell Lung Cancer|Stage IV Ovarian Cancer|Stage IV Small Cell Lung Carcinoma|Triple-Negative Breast Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Talazoparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Once Versus Twice Daily Iron Supplementation in Pregnant Women
Status: UNKNOWN
Conditions: Anemia in Pregnancy
Interventions: DRUG: Placebo|DRUG: Ferrous Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Efficacy and Safety of Guselkumab Administered Subcutaneously in Participants With Active Psoriatic Arthritis Including Those Previously Treated With Biologic Anti -Tumor Necrosis Factor (TNF) Alpha Agent(s)
Status: COMPLETED
Conditions: Arthritis, Psoriatic
Interventions: DRUG: Guselkumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Low Frequency Magnet Therapy on Spasticity in Patients With Cerebral Palsy
Status: COMPLETED
Conditions: Spastic Cerebral Palsy
Interventions: DEVICE: Low frequency magnetic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacological Treatment on the Recovery of Neurosensory Disturbance After Bilateral Sagittal Split Osteotomy
Status: NOT_YET_RECRUITING
Conditions: Retrognathism|Prognathism|Orthognathic Surgery|Neurosensory Disorder
Interventions: PROCEDURE: Orthognathic Surgery|DRUG: Melatonin 10 MG Oral Tablet|DRUG: Hydroxycobalamin|DRUG: Centrum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib Combined With TACE to Prevent the Recurrence in High-risk Patients With Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: lenvatinib|PROCEDURE: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Vitamin D in Amelioration of Oral Lichen Planus and Its Effect on Salivary IFN-γ Level
Status: COMPLETED
Conditions: Oral Lichen Planus|Vitamin D Deficiency
Interventions: DRUG: vitamin D supplement was given as 60,000 IU weekly in conjunction with systemic prednisone|DRUG: Systemic prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Pioglitazone on TIMP-3 and TACE in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Influence of High Intensity Exercise on Insulin Resistance, Muscle Contractile Properties, Aerobic Capacity and Body Composition in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Healthy Controls
Interventions: BEHAVIORAL: Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Group Training for Parents Whose Children Suffer From ADHD and Comorbidity Using a Behavioral-Dynamic Approach
Status: COMPLETED
Conditions: ADHD
Interventions: BEHAVIORAL: Schema Parent Behavioral Training|BEHAVIORAL: Parent Behavioral Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of 4-aminopyridine on Cognitive Performance and Motor Function of Patients With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: 4-aminopyridine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Gynecological Laparoscopy Under Total Intravenous Anesthesia
Status: COMPLETED
Conditions: Butorphanol
Interventions: DRUG: tartaric acid butorphanol|DRUG: normal saline|DRUG: propofol and remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: ASP-II: Ancrod Stroke Program: Ancrod (Viprinex™) for the Treatment of Acute, Ischemic Stroke
Status: TERMINATED
Conditions: Stroke|Cerebral Ischemia|Brain Infarction
Interventions: BIOLOGICAL: Ancrod (Viprinex)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Ilioinguinal/Iliohypogastric Nerve Block Compared to the Combined Therapy With Spermatic Cord Block
Status: COMPLETED
Conditions: Hernia, Inguinal
Interventions: DRUG: Levobupivacaine|PROCEDURE: Ilioinguinal/iliohypogastric nerve block (IINB)|PROCEDURE: IINB+ Spermatic cord block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diet Modification in pAtients With Luminal Early Breast Cancer Candidate for Primary Surgery
Status: RECRUITING
Conditions: Breast Cancer|Surgery
Interventions: DIETARY_SUPPLEMENT: iso-caloric ketogenic diet|DIETARY_SUPPLEMENT: protein restricted diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label, 8-week Safety, Efficacy, and Assessment of Cooling Methods for Administration of CNTX-4975-05 for Knee OA
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: CNTX-4975-05|DRUG: Lidocaine without epinephrine|DEVICE: ElastoGel|DEVICE: Breg Ice Water Pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Efficacy and Safety of Anti-MAP (Mycobacterium Avium Ssp. Paratuberculosis) Therapy in Adult Crohn's Disease
Status: COMPLETED
Conditions: Crohn Disease
Interventions: DRUG: RHB-104 (fixed-dose combination: 95 mg clarithromycin, 45 mg rifabutin, and 10 mg clofazimine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of the Hypoxia Measured in FAZA and F-miso PET/CT Scan in Patients With Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DEVICE: Miso PET scan|DEVICE: FAZA PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of NKTR 255 in Combination With Cetuximab in Solid Tumors
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma|Colorectal Cancer|Cutaneous Squamous Cell Carcinoma|Anal Squamous Cell Carcinoma|Cervical Cancer
Interventions: DRUG: NKTR-255|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: rTMS for Treatment of Depressed Phase of Bipolar Disorder Type II
Status: WITHDRAWN
Conditions: Bipolar Disorder
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain and Anxiety Management of Traumatic Emergency in a Pre-hospital Setting
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Atarax (Hydroxyzine)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy Safety and Tolerability of Ultevursen in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene (Sirius)
Status: TERMINATED
Conditions: Retinitis Pigmentosa|Usher Syndrome Type 2|Deaf Blind|Retinal Disease|Eye Diseases|Eye Diseases, Hereditary|Eye Disorders Congenital|Vision Disorders
Interventions: DRUG: Ultevursen|OTHER: Sham-procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Sequential Therapy of Peginterferon Alfa-2a Following Entecavir in Patient With Chronic Hepatitis B.
Status: UNKNOWN
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Entecavir and Pegylated interferon α-2a Sequential Treatment Group|DRUG: Pegylated interferon α-2a Monotreatment Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Efficacy and Safety of Afimetoran Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE)
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Afimetoran|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study for Safety and Acute Performance Evaluation of the THERMOCOOL SMARTTOUCH® SF-5D System Used With Fast Ablation Mode in Treatment of Patients With Paroxysmal Atrial Fibrillation.
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: THERMOCOOL SMARTTOUCH SF-5D Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IVF Outcome Following Treatment With Ulipristal Acetate for Myomatous Uterus After at Least One IVF Failure
Status: UNKNOWN
Conditions: Women With Leiomyoma After at Least One Unsuccessful IVF Treatment
Interventions: DRUG: Ulipristal acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of SGN-CD47M in Patients With Solid Tumors
Status: TERMINATED
Conditions: Soft Tissue Sarcoma|Colorectal Cancer|Head and Neck Squamous Cell Carcinoma|Non-small Cell Lung Carcinoma|Breast Carcinoma|Ovarian Carcinoma|Exocrine Pancreatic Carcinoma|Gastric Carcinoma|Melanoma
Interventions: DRUG: SGN-CD47M
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of an Oral Health Education Programme of Adolescents in Hong Kong
Status: COMPLETED
Conditions: Caries, Dental|Periodontal Diseases
Interventions: BEHAVIORAL: peer-led theory-based intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of DCR-PHXC-101 in Normal Healthy Volunteers and Patients With Primary Hyperoxaluria
Status: COMPLETED
Conditions: Primary Hyperoxaluria
Interventions: DRUG: DCR-PHXC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Select Rational Therapeutics Based on the Analysis of Matched Tumor and Normal Biopsies in Subjects With Advanced Malignancies
Status: COMPLETED
Conditions: Metastatic Cancer
Interventions: PROCEDURE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study Pilot About the Contribution of Pleuropulmonary Echography Iin Acute Bronchiolitis Among Infants
Status: UNKNOWN
Conditions: Bronchiolitis
Interventions: DEVICE: Pleuropulmonary echography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Krill Oil and Muscle in Older Adults
Status: COMPLETED
Conditions: Aging|Sarcopenia
Interventions: DIETARY_SUPPLEMENT: Krill Oil|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of XMT-1660 in Participants With Solid Tumors
Status: RECRUITING
Conditions: Triple Negative Breast Cancer|Breast Cancer|Endometrial Cancer|Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Cavity Cancer|Adenoid Cystic Carcinoma
Interventions: DRUG: XMT-1660
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Free Fall Acrobatics to Reduce Neck Loads During Parachute Opening Shock: Evaluation of an Intervention.
Status: COMPLETED
Conditions: Pain|Athletic Injuries|Whiplash Injuries|Biomechanical Lesion, Unspecified
Interventions: BEHAVIORAL: Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Buprenorphine and Methadone for Opioid Dependent Chronic Pain Patients
Status: COMPLETED
Conditions: Opiate Addiction
Interventions: DRUG: Methadone|DRUG: Buprenorphine/naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of Pregabalin as Add-On Therapy for Partial Onset Seizures in Children Ages 4-16 Years
Status: COMPLETED
Conditions: Epilepsy, Partial Seizures
Interventions: DRUG: Pregabalin add-on therapy|DRUG: Pregabalin add-on therapy|DRUG: Pregabalin add-on therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy of Dry Needling and Balneotherapy in the Treatment of Myofascial Pain Syndrome
Status: COMPLETED
Conditions: Myofascial Pain Syndrome of Neck
Interventions: OTHER: dry needling|OTHER: balneotherapy|OTHER: dry needling +balneotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Thoracolumbar Fascia Stretching on Pain Parameters With Non-Specific Chronic Low Back Pain
Status: RECRUITING
Conditions: Pain|Low Back Pain
Interventions: OTHER: TLF fascial stretching exercise|OTHER: conventional physiotherapy program.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of a Technology-based System and an In-person Behavioral Weight Loss Intervention in the Severely Obese
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: In-Person weight loss|BEHAVIORAL: FIT weight loss|BEHAVIORAL: FIT-BT weight loss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ipilimumab and Nivolumab for the Treatment of Stage III-IV Unresectable Metastatic Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Clinical Stage III Cutaneous Melanoma AJCC v8|Clinical Stage IV Cutaneous Melanoma AJCC v8|Metastatic Melanoma|Unresectable Melanoma
Interventions: BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab|PROCEDURE: Lymph Node Assessment|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tailored Pfannenstiel Incision for Caesarean Delivery According to the Fetal Head Occipitofrontal Diameter
Status: COMPLETED
Conditions: Incision, Surgical|Cesarean Delivery Affecting Fetus|Pfannenstiel Incision Length|Fetal Occipitofrontal Diameter
Interventions: PROCEDURE: Adjusting the Pfannenstiel skin incision according to the occipitofrontal diameter (OFD) of the fetal head.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Adalimumab to Lower Cardiovascular Risk in RA Patients With Well Controlled Joint Disease
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Cardiovascular Disease
Interventions: DRUG: Adalimumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Disability, MRI Lesions and Thickness of Retinal Fibers: Evaluation 15 Years After a First Episode of Demyelination
Status: COMPLETED
Conditions: Multiple Sclerosis|Pathologic Processes|Tomography, Optical Coherence|Magnetic Resonance Imaging|Prognosis
Interventions: DEVICE: Cerebral MRI and Optical Coherence Tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioavailability, Pharmacokinetic and Mechanistic Study of Sinetrol® Xpur, a Polyphenol-rich Ingredient
Status: COMPLETED
Conditions: Overweight
Interventions: DIETARY_SUPPLEMENT: Verum900|DIETARY_SUPPLEMENT: Verum1800
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Responses to COVID19 Vaccination in Patients With a Treatment History of Rituximab.
Status: UNKNOWN
Conditions: COVID19 Vaccination|Rituximab|Immunosuppression
Interventions: DRUG: History of exposure to anti-CD20 treatment since 01/01/2010|BIOLOGICAL: Completion of COVID19 vaccine at least 4 weeks ago
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Improving Hand Recovery With Neuromodulation in Tetraplegia
Status: TERMINATED
Conditions: Spinal Cord Injuries|Tetraplegia, Unspecified, Incomplete, Chronic
Interventions: DEVICE: transcranial direct current stimulation|BEHAVIORAL: Intensive upper extremity motor training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 3-week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07009)
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Asenapine|DRUG: Olanzapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of the Effects of Two Local Anesthetics Administered Intrathecally: 0.5% Levobupivacaine and Ropivacaine 0.5%
Status: COMPLETED
Conditions: Patients Undergoing Lower Limb Surgery
Interventions: DRUG: ropivacaïne|DRUG: lévobupivacaïne
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Phosphate Binders on FGF-23 With Concurrent Calcitriol
Status: COMPLETED
Conditions: Chronic Kidney Disease Stage 3
Interventions: DRUG: Calcitriol|DRUG: Calcium Carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Mefenamic Acid and Hyoscine for Pain Relief During Saline Infusion Sonohysterography in Infertile Women
Status: UNKNOWN
Conditions: Infertility
Interventions: DRUG: Mefenamic acid or Hyoscine or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extended Pelvic Lymph Node Dissection vs. no Pelvic Lymph Node Dissection at Radical Prostatectomy for intermediate-and High-risk Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: PROCEDURE: Radical prostatectomy (RP) followed by ePLND|PROCEDURE: Radical prostatectomy (RP) only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label Safety Study of E/C/F/TAF (Genvoya®) in HIV-1 Positive Patients With Mild to Moderate Renal Impairment
Status: COMPLETED
Conditions: HIV|HIV Infections
Interventions: DRUG: E/C/F/TAF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Pharmacokinetic, Pharmacodynamic, and Safety Study of 1 Dose Level of Aspirin for Injection and Oral Aspirin Tablets in Healthy Adult Human Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rho-11|DRUG: aspirin 325mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: ADIE-FS - Aligning Dimensions of Interoceptive Experience in Patients With Functional Seizures
Status: RECRUITING
Conditions: Psychogenic Nonepileptic Seizures|Dissociative Seizures|Psychogenic Pseudoseizure|Functional Neurological Disorder|Non Epileptic Seizure
Interventions: BEHAVIORAL: Interoceptive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Cessation of Sedation and TTM in Patients With a Favourable EEG After Cardiac Arrest
Status: RECRUITING
Conditions: Hypoxia-Ischemia, Brain|Heart Arrest
Interventions: OTHER: Early cessation of sedation and TTM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Exenatide Once Weekly in Patients With Type 2 Diabetes Mellitus Treated With Thiazolidinedione Alone or Thiazolidinedione in Combination With Metformin
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COOL MI II: Cooling as an Adjunctive Therapy to Percutaneous Intervention in Patients With Acute Myocardial Infarction
Status: TERMINATED
Conditions: Acute Myocardial Infarction
Interventions: DEVICE: Reprieve Endovascular Temperature Therapy System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gel-200 Versus Placebo in Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DEVICE: Gel-200|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Oxybutynin for Treatment of Hyperidrosis: Local or Systemic Effect?
Status: RECRUITING
Conditions: Hyperhidrosis|Oxybutynin|Sweat Gland Diseases|Skin Diseases|Autonomic Agents|Cholinergic Antagonists|Parasympatholytics
Interventions: DRUG: Topical oxybutynin spray|DRUG: Topical placebo spray|DRUG: Oral oxybutynin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Phase 3 Study to Examine the Long-Term Safety, Tolerability and Efficacy of APL-130277 for the Acute Treatment of "OFF" Episodes in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: APL-130277
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Three Existing Starting Points of Anti-Retroviral Therapy (ART) Initiation in HIV/Tuberculosis (TB) Co-infected Patients
Status: COMPLETED
Conditions: HIV Infections|Tuberculosis
Interventions: DRUG: Early versus intermediate versus late initiation of ART
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Teriflunomide (HMR1726) in Multiple Sclerosis With Relapses
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Teriflunomide|DRUG: Placebo (placebo for teriflunomide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SpareBrain - Mechanisms and Prevention of Secondary Brain Injury in Subarachnoid Haemorrhage
Status: COMPLETED
Conditions: Aneurysmal Subarachnoid Hemorrhage
Interventions: PROCEDURE: Magnetic resonance imaging|PROCEDURE: Cerebral microdialysis catheter insertion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Azoles Targeting Recurrent High Grade Gliomas
Status: NOT_YET_RECRUITING
Conditions: Brain Tumor, Recurrent|Cancer, Advanced|Glioma of Brain
Interventions: DRUG: Ketoconazole (KCZ)|DRUG: Posaconazole (PCZ)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of LY3437943 in Healthy Participants With a High Body Mass Index
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DRUG: LY3437943|DRUG: LY3437943
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacokinetics and Safety of HCP1105 and Co-administration of HGP0918, HGP0816 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Hyperlipidemias
Interventions: DRUG: HCP1105|DRUG: HCP0918|DRUG: HCP0816
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of The Effectiveness Of Wafermine Alone And In Combination With Opioids In Subjects Undergoing Bunionectomy
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: Wafermine|DRUG: Oxycodone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: China Made Sirolimus Eluting Stent for Intermediate Lesion
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: China-made SES (Firebird 2 and Excel)|OTHER: routine medicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Short Term Outcomes Between Totally Laparoscopic and Laparoscopy-Assisted Distal Gastrectomy With Billroth-II Reconstruction and D2 Lymphadenectomy for Locally Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Total Laparoscopic Distal Gastrectomy|Locally Advanced Gastric Cancer
Interventions: PROCEDURE: TLDG or LADG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of DWJ1248 in Patients With Mild to Moderate COVID-19 Compared to the Placebo
Status: TERMINATED
Conditions: Mild to Moderate COVID-19
Interventions: OTHER: Part 1|OTHER: Part 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Refusal of Breast Surgery in Patients With Breast Cancer With a Clinical Complete Response (cCR) After Neoadjuvant Systemic Therapy and a Confirmed Pathological Complete Response (pCR) Using Vacuum-assisted Biopsy (VAB) and Sentinel Lymph Node Biopsy (SLNB)
Status: RECRUITING
Conditions: Refusal of Breast Surgery in Patients With Breast Cancer With a cCR After NST and a Confirmed Pathological Complete Response (pCR) Using VAB and SLNB
Interventions: PROCEDURE: Vacuum-assisted biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Sleeve Gastrectomy as Bridge-to-Candidacy for Obese Left-Ventricular Assist Device Patients
Status: UNKNOWN
Conditions: Heart Failure|Obesity
Interventions: PROCEDURE: Laparoscopic Sleeve Gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-CD19 White Blood Cells for Children and Young Adults With B Cell Leukemia or Lymphoma
Status: COMPLETED
Conditions: ALL|B Cell Lymphoma|Leukemia|Large Cell Lymphoma|Non-Hodgkin Lymphoma
Interventions: BIOLOGICAL: Anti-Cluster of Differentiation (CD)19-Chimeric antigen receptor (CAR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Low Dose Oral Contraceptive Pill to Treat Primary Dysmenorrhea
Status: COMPLETED
Conditions: Dysmenorrhea
Interventions: DRUG: IKH-01|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intraperitoneal and Extraperitoneal Uterosacral Ligament Suspensions for Post-Hysterectomy Vaginal Vault Prolapse
Status: UNKNOWN
Conditions: Vaginal Vault Prolapse|Post-Hysterectomy Vaginal Vault Prolapse|Prolapse, Vaginal
Interventions: PROCEDURE: Intraperitoneal Uterosacral Ligament Suspension|PROCEDURE: Extraperitoneal Uterosacral Ligament Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of JTT-705 in Combination With Pravastatin 40 mg in Patients With Type II Hyperlipidemia
Status: COMPLETED
Conditions: Type II Hyperlipidemia
Interventions: DRUG: JTT-705 600 mg and pravastatin 40 mg|DRUG: JTT-705 300 mg and pravastatin 40 mg|DRUG: Placebo and pravastatin 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Different Dosing Schedules of Selinexor in Sarcoma Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Soft Tissue Sarcoma|Malignant Peripheral Nerve Sheath Tumor (MPNST)|Leiomyosarcoma|Endometrial Stromal Sarcoma
Interventions: DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Hypofractionated Stereotactic Boost (Radiotherapy) for Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: RADIATION: Hypofractionated Stereotactic Boost|DRUG: Carboplatin|DRUG: Paclitaxel|RADIATION: Image-guided IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Foot Reflexology on Preeclampsia
Status: RECRUITING
Conditions: Mild Pre-eclampsia
Interventions: OTHER: methyldopa tablets 250mg|OTHER: methyldopa tablets 250mg + foot reflexology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of 4 Influenza Vaccines in Seniors
Status: COMPLETED
Conditions: Influenza Vaccine
Interventions: BIOLOGICAL: Agriflu|BIOLOGICAL: Fluad|BIOLOGICAL: Intanza|BIOLOGICAL: Vaxigrip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Radiotherapy in Combination With Atezolizumab in Locally Advanced Borderline Resectable or Unresectable Cutaneous SCC
Status: RECRUITING
Conditions: Locally Advanced Skin Squamous Cell Carcinoma|Resectable Skin Squamous Cell Carcinoma|Unresectable Skin Squamous Cell Carcinoma
Interventions: BIOLOGICAL: Atezolizumab|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of CVI-LM001 in Patients With Hypercholesterolemia
Status: UNKNOWN
Conditions: Hyperlipidemia
Interventions: DRUG: 100 mg|DRUG: 200 mg|DRUG: 300 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GB004 in Adult Subjects With Active Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: GB004|DRUG: Placebo|DRUG: GB004
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PET Imaging of Patients With Melanoma and Malignant Brain Tumors Using an 124I-labeled cRGDY Silica Nanomolecular Particle Tracer: A Microdosing Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Newly Diagnosed or Recurrent Metastatic Melanoma Patients|Malignant Brain Tumors
Interventions: DRUG: PET scan with 124I-cRGDY-PEG-dots
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Antibiotic Treatment to Patients With Low Back Pain
Status: COMPLETED
Conditions: Back Pain
Interventions: DRUG: Bioclavid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of CNTO 888 in Combination With SoC (Standard of Care) Chemotherapy in Patients With Solid Tumors
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: CNTO888+DOXIL®/ Caelyx® doxorubicin HCl liposome injection|DRUG: CNTO888 + gemcitabine|DRUG: CNTO888 + Paclitaxel and carboplatin|DRUG: CNTO888 + docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT