pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: To Study the Effect of Nonselective Beta Blockers in Advanced Stage Liver Disease With Ascites
Status: COMPLETED
Conditions: Ascites
Interventions: DRUG: Propranolol|PROCEDURE: Endoscopic variceal ligation (EVL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chlorproguanil-Dapsone-Artesunate (CDA) Versus Chlorproguanil-Dapsone (LAPDAP) For Uncomplicated Malaria
Status: COMPLETED
Conditions: Malaria, Falciparum
Interventions: DRUG: chlorproguanil-dapsone-artesunate|DRUG: chlorproguanil-dapsone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tunneled Dialysis Catheters Versus Non-tunneled Dialysis Catheters as First-line for Renal Replacement Therapy in the ICU
Status: UNKNOWN
Conditions: Acute Kidney Injury
Interventions: DEVICE: Tunneled versus non-tunneled dialysis catheter insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Awake Surgery With Electrocorticographic Recordings in the Management of Gliomas and Correlation With Imaging Data (ECoG)
Status: TERMINATED
Conditions: Electrocorticography|Karnofski Index|Glioma
Interventions: PROCEDURE: ECoG : electrocorticography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Influence of Fedratinib on the Pharmacokinetics of the Transporter Probe Substrates Digoxin, Rosuvastatin, and Metformin
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Fedratinib|DRUG: Digoxin|DRUG: Rosuvastatin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of APSCTC for the Treatment of Postsurgical Pain Due to Third Molar Extraction
Status: RECRUITING
Conditions: Postsurgical Pain|Third Molar Extraction
Interventions: DRUG: APSCTC|DRUG: Toragesic®|DRUG: Tramal®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ologen (OculusGen)-Glaucoma and Pterygium Historical Control Study in Beijing Remin Hospital
Status: COMPLETED
Conditions: Glaucoma|Pterygium
Interventions: DEVICE: OculusGen Biodegradable Collagen Matrix Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)
Status: RECRUITING
Conditions: Progressive Pulmonary Fibrosis|Interstitial Lung Disease
Interventions: DRUG: Placebo|DRUG: Inhaled Treprostinil|DEVICE: Treprostinil Ultrasonic Nebulizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Refraction Determination Analysis
Status: COMPLETED
Conditions: Myopia,|Hyperopia,|Astigmatism,|Presbyopia,|Eye Strain,
Interventions: DEVICE: Telemedicine refraction|DEVICE: Traditional refraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetic Study on the Addition of Aprepitant to Cisplatin - Etoposide Treatment in Lung Cancer Patients
Status: TERMINATED
Conditions: Tumor
Interventions: DRUG: aprepitant|DRUG: Dexamethasone and Ondansetron during CE-treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Psychophysiologic Study of Weakening Traumatic Combat Memories With Post-Reactivation Propranolol
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: Propranolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Telephone-Based Intervention to Treat Depression and Anxiety in Hispanic Cancer Survivors
Status: COMPLETED
Conditions: Survivorship|Cancer|Depression, Anxiety
Interventions: BEHAVIORAL: Telephone interview|BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetics and Pharmacodynamics of Tranexamic Acid in Women Having Caesarean Section Birth [WOMAN-PharmacoTXA]
Status: COMPLETED
Conditions: Pregnancy, High Risk
Interventions: DRUG: Tranexamic Acid 100Mg/Ml Inj Vil 10Ml|DRUG: Tranexamic Acid Oral Solution|DRUG: Tranexamic Acid Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Carfilzomib, Clarithromycin (Biaxin®), Lenalidomide (Revlimid®), and Dexamethasone (Decadron®) [Car-BiRD] Therapy for Subjects With Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: carfilzomib|DRUG: Dexamethasone|DRUG: Clarithromycin|DRUG: Lenalidomide|DRUG: Dexamethasone|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Use of Exenatide in People With Type 2 Diabetes and Diastolic Heart Failure
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2|Heart Failure, Diastolic
Interventions: DRUG: Exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Platlet Aggregation of Clopidogrel, EC Aspirin 81 mg, EC Omeprazole 40 mg Compare to PA32540
Status: COMPLETED
Conditions: Platelet Aggregation
Interventions: DRUG: Plavix® and PA32540|DRUG: EC aspirin (Bayer®) ,EC omeprazole (Prilosec®) , Clopidogrel (Plavix®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Cardiac MRI in Early Stages of STEMI to Predict Left Ventricular Function Recovery and ICD Implantation
Status: TERMINATED
Conditions: Acute STEMI|Severe Left Ventricular Systolic Dysfunction (Disorder)
Interventions: OTHER: Gadolinium-enhanced cardiac MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety of SPD465 in Treating Adults With ADHD.
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: Neutral salts of dextroamphetamine sulfate, USP, amphetamine sulfate, USP, d-amphetamine saccharate, d, l-amphetamine aspartate monohydrate.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Late Boost Strategies for HIV-uninfected Participants From Protocol RV 144
Status: UNKNOWN
Conditions: HIV Infections
Interventions: BIOLOGICAL: ALVAC-HIV|BIOLOGICAL: AIDSVAX B/E|BIOLOGICAL: ALVAC-HIV Placebo|BIOLOGICAL: AIDSVAX B/E Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Letrozole Plus Oral Cyclophosphamide Plus/Minus Sorafenib as Primary Systemic Treatment in Breast Cancer Patients
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: letrozolo+cyclophosphamide|DRUG: letrozolo+sorafenib+cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Ceftaroline Fosamil Versus a Comparator in Adult Subjects With Community-acquired Bacterial Pneumonia (CABP) With Risk for Methicillin-resistant Staphylococcus Aureus
Status: COMPLETED
Conditions: Infections
Interventions: DRUG: Ceftaroline fosamil|DRUG: Ceftriaxone plus vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Supplemental Citicoline Administration to Reduce Lung Injury Efficacy Trial (SCARLET)
Status: RECRUITING
Conditions: COVID-19
Interventions: DRUG: Citicoline|DRUG: Saline/Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The BEET-BP Trial - Investigating the Effect of Dietary Nitrates on Hypertension in Pregnancy
Status: UNKNOWN
Conditions: Hypertension in Pregnancy|Pre-Eclampsia|Gestational Hypertension|Pregnancy Induced Hypertension
Interventions: DIETARY_SUPPLEMENT: Concentrated beetroot juice|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy of BGG492 as Adjunctive Treatment in Patients With Refractory Partial Onset Seizures
Status: WITHDRAWN
Conditions: Partial Onset Seizures
Interventions: DRUG: BGG492|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of DPPIs on Cognitive Function of Diabetic Patients
Status: NOT_YET_RECRUITING
Conditions: Cognitive Impairment
Interventions: DRUG: Control group|DRUG: DPP-4 inhibitor group|DRUG: DPP-4 inhibitor + metformin group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prospective Clinical Study to Assess the Safety and Efficacy of Versius, in Transoral Robotic Surgery
Status: RECRUITING
Conditions: Squamous Cell Carcinoma of the Oropharynx|Squamous Cell Carcinoma, Unknown Primary
Interventions: DEVICE: Versius Surgical System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stentless Florence Robotic Intracorporeal Neobladder (FloRIN)
Status: RECRUITING
Conditions: Perioperative Complication
Interventions: PROCEDURE: Robot assisted radical cystectomy without mono J ureteral stent placement|PROCEDURE: Robot assisted radical cystectomy with mono J ureteral stent placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Targeting of 15-Lipoxygenase-1 (15-LOX-1) for Apoptosis Induction in Human Colorectal Cancers
Status: COMPLETED
Conditions: Familial Adenomatous Polyposis
Interventions: DRUG: Celecoxib|PROCEDURE: Colonoscopy Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Two Fixed-dose Combinations in Men With Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia. (BENIPRO)
Status: NOT_YET_RECRUITING
Conditions: Benign Prostatic Hyperplasia With Lower Urinary Tract Symptoms
Interventions: DRUG: N0728|DRUG: Vesomni®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Root Coverage With Connective Tissue Graft Associated With VISTA Versus Tunnel Technique
Status: UNKNOWN
Conditions: Root Coverage|Tunneling Technique|VISTA Technique|Sub Epithelial Connective Tissue Graft
Interventions: PROCEDURE: VISTA (vestibular incision subperiosteal tunnel acess)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Herbal Lollipops on Oral Bacterial Levels and DMFT/Dmft Scores of Children With Asthma Using Inhalers
Status: TERMINATED
Conditions: Asthma|Dental Caries
Interventions: DIETARY_SUPPLEMENT: Chinese Licorice Root
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Transforaminal Epidural Steroid and Its Combination With Ozone in Lumbar Radiculopathy
Status: COMPLETED
Conditions: Low Back Pain|Radiculopathy Lumbar|Hernia|Disk Herniated Lumbar
Interventions: PROCEDURE: Fluoroscopy Guided Transforaminal Epidural Ozone Injection|PROCEDURE: Fluoroscopy Guided Transforaminal Epidural Steroid Injection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Characteristics and Temporal Properties of Individual Tics in Persistent Tic Disorder
Status: RECRUITING
Conditions: Tics|Tic Disorders|Vocal Tic|Motor Tic|Tourette Syndrome|Tourette Syndrome in Children|Tourette Syndrome in Adolescence|Tics/Tremor
Interventions: BEHAVIORAL: Habit Reversal Training (HRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Convalescent Plasma for Patients With COVID-19: A Randomized, Single Blinded, Parallel, Controlled Clinical Study
Status: COMPLETED
Conditions: Coronavirus|Coronavirus Infection
Interventions: DRUG: Plasma|DRUG: Standard Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Escitalopram Augmentation in Treatment Resistant Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Dexketoprofen and Etoricoxib in Patients Undergoing Hip Arthroplasty
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Dexketoprofen|DRUG: Etoricoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Therapeutic Effect and Safety of Adjunctive AKST4290 in Subjects With Bullous Pemphigoid
Status: TERMINATED
Conditions: Pemphigoid, Bullous
Interventions: DRUG: Mometasone furoate|DRUG: AKST4290|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metabonomics to Investigate Effects of Healthy Diets on Blood Pressure: the OmniHeart Study
Status: COMPLETED
Conditions: Hypertension
Interventions: OTHER: CARB rich diet|OTHER: MUFA rich diet|OTHER: PROT rich diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Interprofessional Training to Improve the Uptake of Noninvasive Ventilation in Patients Hospitalized With Severe COPD Exacerbation
Status: WITHDRAWN
Conditions: Copd
Interventions: OTHER: Interprofessional Education (IPE)|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Refreshing Recess: Staff and Student Feedback Outcome Study (EMCRR)
Status: COMPLETED
Conditions: Interpersonal Relations|Occupational Therapy
Interventions: BEHAVIORAL: Refreshing Recess program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: ThermoSmart® Versus Conventional Humidification in Continuous Positive Airway Pressure (CPAP)
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DEVICE: CPAP with ThermoSmart, then CPAP without ThermoSmart|DEVICE: CPAP without ThermoSmart, then CPAP with ThermoSmart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Dietary Nitrate on Vascular Dysfunction and Inflammation
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: BIOLOGICAL: Typhoid vaccine|DIETARY_SUPPLEMENT: Concentrate beetroot Juice|DIETARY_SUPPLEMENT: Concentrate beetroot Juice (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Short Interval in Treatment of PJI
Status: UNKNOWN
Conditions: Hip Prosthetic Joint Infection|Knee Prosthetic Joint Infection|Shoulder Prosthetic Joint Infection
Interventions: PROCEDURE: Shortening of the interval of two-stage prosthesis exchange
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Combination of Luspatercept in LR-MDS Without RS Having Failed or Being Ineligible to ESA
Status: RECRUITING
Conditions: MDS|Myelodysplastic Syndromes
Interventions: DRUG: Luspatercept Injection [Reblozyl]|DRUG: Eprex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of OrasaltsTM in the Treatment of Gingivitis
Status: COMPLETED
Conditions: Gingivitis
Interventions: OTHER: OrasaltsTM|OTHER: Sea salt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Insulin Aspart in MDI or CSII in Children Below 7 Years of Age With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin aspart|DRUG: soluble human insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Therapeutic INduced HYPERTENSION in Acute Non-cardioembolic Ischemic Stroke (SETIN-HYPERTENSION)
Status: UNKNOWN
Conditions: Stroke, Acute|Progressing Stroke
Interventions: DRUG: Phenylephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Best Postoperative Analgesia Method Following a Minimally Invasive Repair of Pectus Excavatum
Status: RECRUITING
Conditions: Pectus Excavatum|Pain, Postoperative
Interventions: DEVICE: Use of PCA|DEVICE: Use of ESB for postoperative pain control after MIRPE|DEVICE: Use of INC for postoperative pain control after MIRPE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transdermal Nicotine Replacement in Smokers With Acute Aneurysmal Subarachnoid Hemorrhage
Status: COMPLETED
Conditions: Aneurysmal Subarachnoid Hemorrhage
Interventions: DRUG: Nicotine (transdermal)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of 2 Mattresses for the Prevention of Bedsores by Measuring Skin Pressure in the Sacral Area
Status: WITHDRAWN
Conditions: Pressure Ulcer
Interventions: DEVICE: AIRSOFT DUO for 1 day|DEVICE: SENTRY 1200 for 1 month|DEVICE: SENTRY 1200 for 1 day|DEVICE: AIRSOFT DUO for 1 month
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Radium Ra 223 Dichloride, Hormone Therapy and Stereotactic Body Radiation Therapy in Treating Patients With Metastatic Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Adenocarcinoma
Interventions: DRUG: Leuprolide Acetate|DRUG: Goserelin Acetate|RADIATION: Stereotactic Body Radiation Therapy|RADIATION: Radium Ra 223 Dichloride|OTHER: Laboratory Biomarker Analysis|DRUG: Degarelix
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plan D- Vitamin D Supplementation in Psychotic Disorders
Status: RECRUITING
Conditions: Schizophrenia Spectrum and Other Psychotic Disorders
Interventions: DIETARY_SUPPLEMENT: Vitamin D|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Randomized, Double-Blind, Placebo-Controlled Escalating Single Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of ND-L02-s0201 Injection in Normal Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ND-L02-s0201 Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Acute Influence of Resveratrol Supplementation and Beet Extract in Recovery After Exercise in Coronary Paths
Status: COMPLETED
Conditions: Coronary Artery Disease|Autonomic Nervous System Disease|Blood Pressure|Heart Rate
Interventions: OTHER: Placebo Protocol|OTHER: Protocol Beet|OTHER: Protocol Resveratrol|OTHER: Protocol Beet and Resveratrol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Paratracheal Esophagus Pressure on the Insertion of Laryngeal Mask Airway
Status: COMPLETED
Conditions: General Anesthesia|Pulmonary Aspiration
Interventions: PROCEDURE: Paratracheal pressure|PROCEDURE: Cricoid pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Limberg and Karydakis Flap in Recurrent Pilonidal Sinus Disease
Status: COMPLETED
Conditions: Recurrent Pilonidal Sinus Disease
Interventions: PROCEDURE: Limberg flap|PROCEDURE: Karydakis procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enasidenib as Maintenance Therapy in Treating Patients With Acute Myeloid Leukemia With IDH2 Mutation After Donor Stem Cell Transplant
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Enasidenib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Saving Brain in Uganda and Burkina Faso
Status: UNKNOWN
Conditions: Poor Performance Status|Neurologic Deficits|Mixed Behavior and Emotional Disorder|Malnutrition|Infections, Hospital
Interventions: BEHAVIORAL: Peer support for exclusive breastfeeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of the Gene Mutation Status in Cerebrospinal Fluid, Blood and Tumor Tissue of Non-small Cell Lung Cancer Patients With Brain Metastases
Status: UNKNOWN
Conditions: Lung Cancer|Brain Metastases|Cerebrospinal Fluid|Next-generation Sequencing
Interventions: DIAGNOSTIC_TEST: next-generation sequencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate
Status: RECRUITING
Conditions: Overweight|Obesity
Interventions: OTHER: Standard Diet|OTHER: Ketogenic Diet|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Nicotinamide Riboside
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Clinical Study to Evaluate Safety, Tolerability and Pharmacokinetics of Oral HMS5552 in Healthy Volunteers
Status: COMPLETED
Conditions: Type II Diabetes Mellitus
Interventions: DRUG: HMS5552|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of CG428 Cutaneous Solution on Chemotherapy Induced Alopecia; Controlled Study (ELAN)
Status: COMPLETED
Conditions: Alopecia
Interventions: DRUG: CG 428 cutaneous solution|DRUG: Placebo cutaneous solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Learn How the Study Treatment Asundexian Moves Into, Through and Out of the Body, How it Works, How Safe it is, and How it Affects the Body in Participants With Mild or Moderate Reduction of Liver Function Compared to Participants With Normal Liver Function
Status: COMPLETED
Conditions: Prevention of Thromboembolic Events|Atrial Fibrillation|Acute Myocardial Infarction|Non-cardioembolic Ischemic Stroke|Hepatic Impairment
Interventions: DRUG: Asundexian (BAY2433334)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluate Effects of Multiple Doses of Rifampin and Clarithromycin on the Single Dose Pharmacokinetics of Deflazacort
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Deflazacort and rifampin|DRUG: Deflazacort and Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glove-based Care in the NICU to Prevent Late Onset Sepsis
Status: COMPLETED
Conditions: Sepsis Newborn|Infection
Interventions: OTHER: Glove based care|OTHER: Standard of Care - Hand Hygiene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: RETIC Trial: Reversal of Trauma Induced Coagulopathy Using Coagulation Factor Concentrates or Fresh Frozen Plasma
Status: TERMINATED
Conditions: Major Trauma
Interventions: DRUG: Fibrinogen concentrate, Prothrombin complex concentrate and FXIII concentrate|DRUG: Fresh Frozen Plasma blood type 0, A, B and AB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: National Wide Cross-sectional Study in Paediatric Central Nervous System Tumours in China -- the CNOG-MC001 Registry
Status: COMPLETED
Conditions: Tumors, Central Nervous System|Pediatric Brain Tumor|Malignant Brain Tumor|Benign Brain Tumor
Interventions: PROCEDURE: Tumour resection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PK, PD and Safety Comparative Trial of Isosorbide Mononitrate Gel in Healthy Participants and With Anal Fissure
Status: WITHDRAWN
Conditions: Anal Fissure
Interventions: DRUG: Isosorbide Mononitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Interscalene Block:3mL Ropi Provide Similar Analgesia to 5mL and Less Diaphragmatic Paralysis
Status: COMPLETED
Conditions: Diaphragmatic Paralysis
Interventions: DRUG: Ropivacaine 0.5% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Alpelisib, Fulvestrant and Dapagliflozin for the Treatment of HR+, HER2 -, PIK3CA Mutant Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Metastatic Breast Cancer|HER2-negative Breast Cancer
Interventions: DRUG: Dapagliflozin 10Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Xoft® Intraoperative Radiotherapy (IORT) for Patients With Early-Stage Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer|Breast Cancer, Invasive Ductal|Invasive Mammary Carcinoma|Breast Cancer Stage I|Breast Cancer Stage IIA
Interventions: RADIATION: Intraoperative radiotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comparison of Two Treatments for CRPS and Changes in Resting-State Connectivity of Cerebral Networks.
Status: RECRUITING
Conditions: Complex Regional Pain Syndrome
Interventions: BEHAVIORAL: GMI and Desensitization|BEHAVIORAL: Desensitization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Elotuzumab in Combination With Carfilzomib, Lenalidomide and Dexamethasone (E-KRd) Versus KRd in MM
Status: ACTIVE_NOT_RECRUITING
Conditions: Newly Diagnosed Multiple Myeloma
Interventions: DRUG: Elotuzumab|DRUG: Carfilzomib|DRUG: Lenalidomide|DRUG: Dexamethasone|OTHER: autologous stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, Tolerability, Pharmacokinetics of Sotrastaurin-tacrolimus vs. Mycophenolic Acid-tacrolimus in de Novo Liver Transplant Patients
Status: COMPLETED
Conditions: Liver Transplantation
Interventions: DRUG: MMF(1000mg bid) + tacrolimus + standard of care medications|DRUG: sotrastaurin (200mg bid) + tacrolimus + standard of care medications|DRUG: sotrastaurin (200mg bid) + tacrolimus + standard of care medications|DRUG: sotrastaurin (300 mg bid) + tacrolimus + standard of care medications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Propolis for Patients With Chronic Kidney Disease.
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Inflammation
Interventions: DIETARY_SUPPLEMENT: Propolis|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma|Liver Cancer
Interventions: BIOLOGICAL: Nivolumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Potential Effect of Innovative Cell-based Therapy Using Adipose-derived Stromal Vascular Fraction in Patients With Autoimmune Xerostomia
Status: NOT_YET_RECRUITING
Conditions: Xerostomia
Interventions: PROCEDURE: lipoaspiration|DRUG: Injection of the autologous adipose-derived stromal vascular fraction (AD-SVF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Rectangular Versus Square Archwire on Maxillary Canine Retraction
Status: ACTIVE_NOT_RECRUITING
Conditions: Canine Retraction
Interventions: DEVICE: Rectangular and square striaght archwire technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Local and Systemic Effects of Photobiomodulation Therapy on Muscle Performance and Recovery Post-exercise.
Status: COMPLETED
Conditions: Phototherapy|Low-level Laser Therapy|Systemic
Interventions: DEVICE: Phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mosunetuzumab With or Without Polatuzumab Vedotin and Obinutuzumab for the Treatment of Untreated Indolent B-Cell Non-Hodgkin Lymphoma
Status: RECRUITING
Conditions: Non-Hodgkin Lymphoma|Grade 1 Follicular Lymphoma|Grade 2 Follicular Lymphoma|Grade 3a Follicular Lymphoma|Indolent B-Cell Non-Hodgkin Lymphoma|Marginal Zone Lymphoma|Recurrent Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue|Refractory Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
Interventions: BIOLOGICAL: Mosunetuzumab|BIOLOGICAL: Obinutuzumab|DRUG: Polatuzumab Vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BE Study of Torrent's Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide Tab - Fed Conditions
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Torrent's Olmesartaan medoxomil, Amlodipine and Hydrochlorothiazide Tablets|DRUG: Tribenzor of Daichi Sankyo Inc. USA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Nivolumab Plus Ipilimumab in Patients With Renal Medullary Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Kidney Medullary Carcinoma|Loss of INI 1 Protein Expression|Stage III Renal Cell Cancer AJCC v8|Stage IV Renal Cell Cancer AJCC v8
Interventions: BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paricalcitol and Zoledronate in Treating Patients With Relapsed or Refractory Multiple Myeloma or Other Plasma Cell Disorders
Status: TERMINATED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: paricalcitol|DRUG: zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Impact of Soft Tissue Mobilization on the Scar in Patients After Cesarean Section
Status: NOT_YET_RECRUITING
Conditions: Cesarean Section Complications
Interventions: OTHER: Manual therapy (myofascial release, soft tissue mobilization)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study in Recurrent or Progressive Grade III or IV IDH1 Mutated Glioma
Status: RECRUITING
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Perillyl alcohol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetis of TAP311 in Dyslipidemic Patients
Status: COMPLETED
Conditions: Dyslipidaemia
Interventions: DRUG: TAP311 capsules|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fibroblast Before and After Neoadjuvant Chemo-radiotherapy in Patient With Locally Advanced Rectal Adenocarcinoma
Status: COMPLETED
Conditions: Rectum Adenocarcinoma
Interventions: OTHER: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Variability of 25-hydroxyvitamin D Response From Crystalline 25-hydroxyvitamin D3
Status: WITHDRAWN
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: cholecalciferol|DIETARY_SUPPLEMENT: 25(OH)D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Molecularly Targeted Umbrella Study in Luminal Advanced Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Metastatic Cancer
Interventions: DRUG: SHR7390|DRUG: Famitinib|DRUG: SHR3162|DRUG: Pyrotinib|DRUG: Capecitabine|DRUG: SHR1210|DRUG: Everolimus|DRUG: Nab paclitaxel|DRUG: SHR2554|DRUG: SHR3680|DRUG: SHR6390|DRUG: SHR1701|DRUG: SERD|DRUG: AI|DRUG: VEGFi
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Study of NightWare for PTSD With Nightmares
Status: COMPLETED
Conditions: PostTraumatic Stress Disorder|Sleep Disorder|Stress Disorder|Sleep Initiation and Maintenance Disorders|Combat Disorders|Nightmares Associated With Chronic Post-Traumatic Stress Disorder|Nightmare|Nightmares, REM-Sleep Type
Interventions: DEVICE: NightWare Therapeutic System|DEVICE: NightWare Therapeutic System in Sham Mode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tourniquet Application on Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Tourniquets|Total Knee Arthroplasty
Interventions: PROCEDURE: Reinflation after early deflation|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nivolumab With or Without Ipilimumab in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Sarcomas
Status: COMPLETED
Conditions: Metastatic Melanoma|Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Recurrent Hodgkin Lymphoma|Recurrent Malignant Solid Neoplasm|Recurrent Melanoma|Recurrent Neuroblastoma|Recurrent Non-Hodgkin Lymphoma|Recurrent Osteosarcoma|Recurrent Rhabdomyosarcoma|Refractory Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Refractory Hodgkin Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Melanoma|Refractory Neuroblastoma|Refractory Non-Hodgkin Lymphoma|Refractory Osteosarcoma|Refractory Rhabdomyosarcoma|Stage III Cutaneous Melanoma AJCC v7|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7|Unresectable Melanoma
Interventions: BIOLOGICAL: Ipilimumab|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Nivolumab|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of HX575 in the Treatment of Chemotherapy Associated Anemia in Cancer Patients
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: HX575, solution for injection (s.c.)|DRUG: ERYPO®, Janssen-Cilag, solution for injection (s.c.)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Open, Prospective Pilot Study to Obtain Aerosol Distribution in Asthmatic Patients Using Single Photon Emission Computed Tomography (SPECT) for Comparison With Functional Imaging Using Computer Methods
Status: COMPLETED
Conditions: Asthma
Interventions: PROCEDURE: Computed Tomography|PROCEDURE: Single Photon Emission Computed Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Non-instrumentation Root Canal Treatment of Primary Molars
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Pulp Diseases|Dental Pulp Necrosis
Interventions: PROCEDURE: Non-instrumentation technique with use of CTZ paste|PROCEDURE: Instrumentation technique and filling with Zinc Oxide and Eugenol paste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of Immune Therapy After Allograft in Patients With Myeloid Hemopathy
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Chronic Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: BIOLOGICAL: recwt1-A10+AS01B
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expanded Access Study of Iodine-131 Anti-B1 Antibody
Status: UNKNOWN
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Iodine-131 Anti-B1 Antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of OPC-262 in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes, Type 2
Interventions: DRUG: saxagliptin|DRUG: saxagliptin|DRUG: saxagliptin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Recognition and Early Intervention for Alcohol and Substance Abuse in Adolescence in Adolescent
Status: RECRUITING
Conditions: Alcoholism|Substance Abuse|Alcohol Dependence|Alcohol-Related Disorders|Substance Use Disorders|Adolescent Behavior|Adolescent Problem Behavior
Interventions: BEHAVIORAL: ASSIST|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Gemcitabine and Oxaliplatin in Recurrent or Metastatic Breast Cancer
Status: TERMINATED
Conditions: Recurrent Breast Cancer|Metastastic Breast Cancer
Interventions: DRUG: Gemcitabine and oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Efficacy of Abatacept in Moderate to Severe Alopecia Areata
Status: WITHDRAWN
Conditions: Alopecia Areata
Interventions: DRUG: Abatacept|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Project Grow Smart: Intervention Trial of Multiple Micronutrients and Early Learning Among Infants in India
Status: COMPLETED
Conditions: Nutritional Deficiencies|Developmental Delay
Interventions: DIETARY_SUPPLEMENT: MNP|BEHAVIORAL: Early Learning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics and Bioavailability of Hydrocortisone Acetate Suppositories
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cortenema|DRUG: Hydrocortisone Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Augmented Response of Volatile Biomarkers in Assessment of Oesophagogastric Cancer (AROMA 1 / BIORESOURCE)
Status: RECRUITING
Conditions: Volatile Organic Compounds|Microbiome|Microbioata|Breath Analysis|Oesophageal Cancer|Gastric Cancer|Volatalomics|Metabonomics/Lipidomics|Microbiome Analysis|Transcriptomics
Interventions: DIETARY_SUPPLEMENT: Oral Stimulant Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mild Water-filtered Infrared-A Whole-body Hyperthermia in Patients With Post-COVID Syndrome (HyPoCo)
Status: RECRUITING
Conditions: Post-COVID Syndrome
Interventions: OTHER: mild hyperthermia group|OTHER: sham group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Long-Term Extension Study of OnabotulinumtoxinA (BOTOX®) for Urinary Incontinence Due to Neurogenic Detrusor Overactivity
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: BIOLOGICAL: OnabotulinumtoxinA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy, Safety and Tolerability of DFV890 in Patients With Knee Osteoarthritis
Status: RECRUITING
Conditions: Symptomatic Knee Osteoarthritis
Interventions: DRUG: DFV890|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Accelerated ART Initiation for PWHIV Who Are Out of Care
Status: RECRUITING
Conditions: HIV Infections|ART|Noncompliance, Patient
Interventions: OTHER: The Accelerate model of care|DRUG: bictegravir/emtricitabine/tenofovir alafenamide 50/200/25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Onartuzumab Combined With Vemurafenib and/or Cobimetinib in Cancer Patients
Status: WITHDRAWN
Conditions: Neoplasms
Interventions: DRUG: Cobimetinib|DRUG: Cobimetinib|DRUG: Onartuzumab|DRUG: Vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of PCUR-101 in Combination With Androgen Suppression Therapy in the Treatment of Patients With Metastatic Castration-Resistant Prostate Cancer
Status: TERMINATED
Conditions: Metastatic Castration-Resistant Prostate Cancer
Interventions: DRUG: PCUR - 101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benefit-Risk Of Arterial THrombotic prEvention With Rivaroxaban for Atrial Fibrillation in France
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)|DRUG: Vitamin K antagonists|DRUG: dabigatran (Pradaxa)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Heroin Use on Immune Activation and Cardiovascular Risk in HIV
Status: COMPLETED
Conditions: HIV Infection|Opioid-use Disorder|Cardiovascular Diseases
Interventions: DRUG: buprenorphine/naloxone|DRUG: Methadone|DRUG: Naltrexone Injection|DRUG: Heroin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Topical Application of Imiquimod Gel at Different Concentrations in Actinic Cheilitis
Status: TERMINATED
Conditions: Actinic Cheilitis
Interventions: DRUG: Vehicle Gel Base|DRUG: Imiquimod 5% gel|DRUG: Imiquimod 0,05% gel|DRUG: Imiquimod nanoencapsulated 0,05% gel|DRUG: Lip sunscreen 30 Sun Protector Factor (SPF)|DRUG: Dexpanthenol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT