pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Trial Investigating the Effect of Oral Semaglutide Compared With Placebo on Postprandial Glucose and Triglyceride Metabolism, Energy Intake, Appetite Sensations and Gastric Emptying in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: semaglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Angiographic Control vs. Ischemia-driven Management of Patients Treated With PCI on Left Main With Drug-eluting Stents
Status: UNKNOWN
Conditions: Acute Coronary Syndrome|Stable Chronic Angina|Coronary Artery Disease|Left Main Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: coronary computed tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Interleukin-6 (IL-6) and IL-6/Soluble IL-6 Receptor (sIL-6R) Complex Levels in Subjects With Active Inflammatory Bowel Disease
Status: COMPLETED
Conditions: Inflammatory Bowel Disease
Interventions: PROCEDURE: Blood sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Kinesiology Tape on Neck Disability
Status: COMPLETED
Conditions: Pain|Myofascial Pain Syndrome|Trigger Point Pain, Myofascial
Interventions: OTHER: kinesiotaping and exercise|OTHER: exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety Study of BHV-7000 in Participants With Major Depressive Disorder (MDD)
Status: ENROLLING_BY_INVITATION
Conditions: Major Depressive Disorder
Interventions: DRUG: BHV-7000
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supraphysiologic Insulin to Improve Outcomes After Surgical Treatment of Unruptured Cerebral Aneurysms
Status: WITHDRAWN
Conditions: Intracranial Aneurysm
Interventions: DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Effects of Oral Xyrem and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea Patients
Status: COMPLETED
Conditions: Obstructive Sleep Apnea Syndrome
Interventions: DRUG: Xyrem (X)|DRUG: Zolpidem (Z)|DRUG: Modafinil (M)|DRUG: Placebo (P)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Use of the Contraceptive Patch and the Personal Economic Impact.
Status: WITHDRAWN
Conditions: Dysmenorrhea|Menstruation Disturbances|Menstruation Disorders
Interventions: DRUG: ORTHO EVRA, the contraceptive patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SMARTease Trial: Evaluating Stroke Help Distance Interventions to Improve Cognitive Performance Post-Stroke
Status: TERMINATED
Conditions: Cognitive Impairment|Stroke
Interventions: BEHAVIORAL: Telerehabilitation Cognitive Strategy Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SYNchronizing Exercises, Remedies in Gait and Cognition at Home (SYNERGIC@Home)
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Combined Aerobic Exercise and Resistance Training (AE + RT)|BEHAVIORAL: Cognitive Training (NeuropeakTM)|BEHAVIORAL: Control Cognitive Training of Website Searching and Video Watching (WS+V)|BEHAVIORAL: Control Balance and Toning Exercise Training (BAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Efficacy and Safety of Pregabalin for the Treatment of Diabetic Peripheral Neuropathy or Postherpetic Neuralgia
Status: COMPLETED
Conditions: Painful Diabetic Neuropathy and Post Herpetic Neuralgia
Interventions: DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Camrelizumab Combined With CD30 CAR-T in the Treatment of Relapsed/Refractory CD30+ Lymphoma
Status: UNKNOWN
Conditions: Lymphoma|Relapse/Recurrence
Interventions: BIOLOGICAL: CD30 CAR-T|DRUG: Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Safety of Biphasic Insulin Aspart 30 in Juveniles With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: biphasic insulin aspart 30
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Insomnia|Sleep Disorder|Inflammation
Interventions: DRUG: Suvorexant|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Combining Eribulin Mesylate With Avelumab in Cisplatin Ineligible Metastatic Urothelial Cell Cancer Patients
Status: TERMINATED
Conditions: Metastatic Urothelial Cell Cancer
Interventions: DRUG: Eribulin Mesylate|DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ORthosis vs No Orthosis After Surgically Treated Traumatic Thoracolumbar Fractures
Status: RECRUITING
Conditions: Spine Fracture|Orthosis|Traumatic Fracture|Posterior Fixation
Interventions: OTHER: No orthosis|DEVICE: Orthosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Safety And Effectiveness Of The Tivoli® DES and The Firebird2® DES For Treatment Coronary Revascularization
Status: UNKNOWN
Conditions: Ischemic Heart Disease|Myocardial Ischemia|Coronary Artery Lesions,Primary|Coronary Disease|Acute Coronary Syndrome|Furcation Lesion of Coronary Artery
Interventions: DEVICE: Tivoli® DES|DEVICE: Firebird2® DES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lonafarnib With and Without Ritonavir in HDV (LOWR-1)
Status: COMPLETED
Conditions: Chronic Hepatitis D Infection
Interventions: DRUG: lonafarnib|DRUG: peginterferon alfa-2a|DRUG: ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Follow-up After Primary or Revision Shoulder Arthroplasty With a Patient- Specific Glenius Implant
Status: ENROLLING_BY_INVITATION
Conditions: Arthroplasty, Replacement, Shoulder|Glenoid Cavity|Osteoarthritis of the Shoulder
Interventions: DEVICE: reversed glenoid prothesis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Autologous Tumor Infiltrating Lymphocytes (GT101 Injection) in Patients With Recurrent or Metastatic Cervical Cancer
Status: RECRUITING
Conditions: Adult
Interventions: BIOLOGICAL: GT101 injection|DRUG: Gemcitabine injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atrioventricular Node Ablation in Patients With Atrial Fibrillation and Moderate Chronic Heart Failure
Status: TERMINATED
Conditions: Heart Failure
Interventions: DEVICE: Implantation of CRT device|DEVICE: Implantation of conventional VVI(R) pacemaker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DRUG: Botulinum Toxin Type A|DRUG: Triamcinolone hexacetonide|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of SRP-4045 (Casimersen) and SRP-4053 (Golodirsen) in Participants With Duchenne Muscular Dystrophy (DMD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: SRP-4045|DRUG: SRP-4053|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Insulin Glargine (LY2963016) in Adult Participants With Type 2 Diabetes in India
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Insulin Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Understanding the Need and Feasibility of Transitional Care Training Program Among Family Caregivers of Geriatric Stroke Survivors in Pakistan
Status: RECRUITING
Conditions: Stroke|Stroke, Ischemic|Stroke Hemorrhagic
Interventions: BEHAVIORAL: Transitional Care Training Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intranasal Injection Versus Topical Administration of Epinephrin During Endoscopic Sinus Surgery
Status: UNKNOWN
Conditions: Hypertension|Hypotension|Tachycardia|Bradycardia|Arrhythmia
Interventions: DRUG: Epinephrin (Intranasal injection)|DRUG: Epinephrin (Topical administration)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BAY63-2521:Long-term Extension Study in Patients With Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Hypertension, Pulmonary
Interventions: DRUG: Riociguat (BAY63-2521)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of XEN® Gel Stent and Post-operative Management in Patients With Open Angle Glaucoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Open-angle Glaucoma
Interventions: DRUG: 5-fluorouracil|PROCEDURE: Transconjunctival needling|PROCEDURE: Transconjunctival revision
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Combined Effect of TENS and TaVNS on Pressure and Heat Pain Thresholds in Pain-Free Subjects
Status: NOT_YET_RECRUITING
Conditions: Healthy Volunteers
Interventions: DEVICE: Active Transcutaneous Auricular Vagus Nerve Stimulation (TaVNS)|DEVICE: Placebo Transcutaneous Auricular Vagus Nerve Stimulation (TaVNS)|DEVICE: Transcutaneous Electrical Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of a Drug and Placebo in the Prevention of Migraine Headaches
Status: TERMINATED
Conditions: Headache, Migraine
Interventions: DRUG: ethosuximide|OTHER: placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
Status: RECRUITING
Conditions: Aortic Stenosis
Interventions: DRUG: Pelacarsen (TQJ230) 80mg|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose-optimization Study of Aldurazyme® (Laronidase) in Patients With Mucopolysaccharidosis I (MPS I) Disease
Status: COMPLETED
Conditions: Mucopolysaccharidosis I|Hurler's Syndrome|Hurler-Scheie Syndrome|Scheie Syndrome
Interventions: BIOLOGICAL: Aldurazyme (Recombinant Human Alpha-L-Iduronidase)|BIOLOGICAL: Aldurazyme (Recombinant Human Alpha-L-Iduronidase)|BIOLOGICAL: Aldurazyme (Recombinant Human Alpha-L-Iduronidase)|BIOLOGICAL: Aldurazyme (Recombinant Human Alpha-L-Iduronidase)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Pain Severity on Injection of MCT/LCT Propofol Between Lidocaine 20 mg, 40 mg, and Without Lidocaine.
Status: COMPLETED
Conditions: Adult Disease
Interventions: DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Growth Hormone in Ischemic Heart Failure
Status: COMPLETED
Conditions: Heart Failure, Systolic|Ischemic Heart Disease Chronic
Interventions: DRUG: Somatropin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Trauma of Betrayal: Treating Adjustment Disorder With Reconsolidation Blockade Under Propranolol
Status: COMPLETED
Conditions: Adjustment Disorders|Posttraumatic Stress Disorder|Trauma and Stressor Related Disorders
Interventions: DRUG: Propranolol Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Whether Nintedanib Influences the Components of Birth-control Pills in Women With Systemic Sclerosis Associated Interstitial Lung Disease (SSc-ILD)
Status: COMPLETED
Conditions: Scleroderma, Systemic
Interventions: DRUG: Microgynon|DRUG: Nintedanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Drug Interactions of AEGR-733 on Lipid-lowering Agents
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: atorvastatin|DRUG: simvastatin|DRUG: ezetimibe|DRUG: fenofibrate|DRUG: dextromethorphan|DRUG: Extended Release Niacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of a Reduced-toxicity Myeloablative Conditioning Regimen Using Fludarabine and Full Doses of Intravenous Busulfan in Pediatric Patients Not Eligible for Standard Myeloablative Conditioning Regimens
Status: COMPLETED
Conditions: Hematologic Malignancy
Interventions: DRUG: Fludarabine IV- Busulfan IV (Busilvex®) - Anti-thymocyte globulines (Thymoglobuline®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brexpiprazole as Adjunctive Treatment in Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Treatment
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Placebo|DRUG: Brexpiprazole|DRUG: ADT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sulforaphane Treatment of Children With Autism Spectrum Disorder (ASD)
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Sulforaphane|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Chicory Inulin-type Fructans in Constipated Adults
Status: COMPLETED
Conditions: Constipation - Functional
Interventions: DIETARY_SUPPLEMENT: chicory inulin-type fructan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rotator Cuff Tears Repair With or Without Dermal Patch Augmentation
Status: RECRUITING
Conditions: Rotator Cuff Tears
Interventions: BIOLOGICAL: Allograft Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Study of BMS-188667 (CTLA4Ig) in Patients With Rheumatoid Arthritis Who Are Currently Failing Anti-TNF Therapy or Who Have Failed Anti-TNF Therapy in the Past.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Abatacept|DRUG: Placebo|DRUG: Abatacept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Beetroot Juice for Boosting Immunity During a Time of Stress.
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Beetroot Juice|DIETARY_SUPPLEMENT: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TBA-354 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: TBA-354|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Megestrol in Treating Patients With Endometrial Neoplasia or Endometrial Hyperplasia
Status: TERMINATED
Conditions: High Grade Squamous Intraepithelial Neoplasia|Stage 0 Uterine Corpus Cancer
Interventions: PROCEDURE: Biopsy|OTHER: Laboratory Biomarker Analysis|DRUG: Megestrol Acetate|OTHER: Pharmacological Study|OTHER: Quality-of-Life Assessment|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3537982 Plus Immunotherapy With or Without Chemotherapy in Participants With Non-Small Cell Lung Cancer (NSCLC) With a Change in a Gene Called KRAS G12C
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung|Neoplasm Metastasis
Interventions: DRUG: LY3537982|DRUG: Pembrolizumab|DRUG: Placebo|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL)
Status: RECRUITING
Conditions: Head and Neck Cancer|Head and Neck Squamous Cell Carcinoma|Oropharynx Cancer|Oropharynx Squamous Cell Carcinoma|HPV Positive Oropharyngeal Squamous Cell Carcinoma
Interventions: OTHER: Experimental Observation|OTHER: Observation per Standard of Care|RADIATION: Adjuvant Treatment per Standard of Care|DIAGNOSTIC_TEST: Circulating Tumor DNA test (ctDNA test)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TIGER-3: Open Label, Multicenter Study of Rociletinib (CO-1686) Mono Therapy Versus Single-agent Cytotoxic Chemotherapy in Patients With Mutant EGFR NSCLC Who Have Failed at Least One Previous EGFR-Directed TKI and Platinum-doublet Chemotherapy
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Rociletinib|DRUG: Pemetrexed or gemcitabine or paclitaxel or docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Solesta for Treatment of Fecal Incontinence
Status: COMPLETED
Conditions: Fecal Incontinence
Interventions: DEVICE: Solesta (Dextranomer in gel of stabilized non-animal hyaluronate)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beacon Sensors and Telerehabilitation to Assess and Improve Use of Devices (BeST-AID) for Low Vision
Status: RECRUITING
Conditions: Low Vision|Low Vision Aids
Interventions: BEHAVIORAL: Low Vision Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decitabine and Valproic Acid in Treating Patients With Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Recurrent Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: DRUG: decitabine|DRUG: valproic acid|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of AMG 301 in Migraine Prevention
Status: COMPLETED
Conditions: Chronic Migraine or Episodic Migraine
Interventions: DRUG: Placebo|DRUG: AMG 301
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Interleukin-2, Vinblastine, and GM-CSF in Treating Patients With Metastatic Kidney Cancer
Status: UNKNOWN
Conditions: Kidney Cancer
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: sargramostim|DRUG: vinblastine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Alpha Radiation Emitters Device for the Treatment of Cutaneous, Mucosal and Superficial Soft Tissue Neoplasia (DaRT)
Status: RECRUITING
Conditions: Skin Cancer|Mucosal Neoplasm of Oral Cavity|Soft Tissue Neoplasm
Interventions: DEVICE: Device: Radiation: Diffusing Alpha Radiation Emitters Therapy (DaRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine and Adenosine: Therapeutic Use for SVT
Status: COMPLETED
Conditions: Supraventricular Tachycardia
Interventions: DRUG: Dexmedetomidine|DRUG: Adenosine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Mesenchymal Stem Cells on Healing of Foot Ulcers in Diabetes Patients.
Status: RECRUITING
Conditions: Diabetic Foot Ulcer|Mesenchymal Stromal Cells
Interventions: DRUG: Adipose tissue derived mesenchymal stromal/stem cells (Cell2Cure®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The BOSS Study: An Acute Evaluation of Anatomical and Geometric Changes Using the Bladder on a Stick System (BOSS)
Status: COMPLETED
Conditions: Functional Mitral Regurgitation|Heart Failure
Interventions: DEVICE: BOSS Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Drug-drug Interaction Following Oral Administration of Telmisartan/Amlodipine and Atorvastatin in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Hypertension With Hyperlipidemia
Interventions: DRUG: telmisartan/amlodipine and atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Look At The Safety Of SB-681323 In Healthy Adult Subjects After Intravenous Administration Of A Single Dose
Status: COMPLETED
Conditions: Arthritis, Rheumatoid|Inflammation
Interventions: DRUG: SB-681323
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
Status: RECRUITING
Conditions: Childhood Extracranial Germ Cell Tumor|Extragonadal Embryonal Carcinoma|Germ Cell Tumor|Malignant Germ Cell Tumor|Malignant Ovarian Teratoma|Stage I Ovarian Choriocarcinoma|Stage I Ovarian Embryonal Carcinoma AJCC v6 and v7|Stage I Ovarian Teratoma AJCC v6 and v7|Stage I Ovarian Yolk Sac Tumor AJCC v6 and v7|Stage I Testicular Choriocarcinoma AJCC v6 and v7|Stage I Testicular Embryonal Carcinoma AJCC v6 and v7|Stage I Testicular Seminoma AJCC v6 and v7|Stage I Testicular Yolk Sac Tumor AJCC v6 and v7|Stage II Ovarian Choriocarcinoma|Stage II Ovarian Embryonal Carcinoma AJCC v6 and v7|Stage II Ovarian Yolk Sac Tumor AJCC v6 and v7|Stage II Testicular Choriocarcinoma AJCC v6 and v7|Stage II Testicular Embryonal Carcinoma AJCC v6 and v7|Stage II Testicular Yolk Sac Tumor AJCC v6 and v7|Stage III Ovarian Choriocarcinoma|Stage III Ovarian Embryonal Carcinoma AJCC v6 and v7|Stage III Ovarian Yolk Sac Tumor AJCC v6 and v7|Stage III Testicular Choriocarcinoma AJCC v6 and v7|Stage III Testicular Embryonal Carcinoma AJCC v6 and v7|Stage III Testicular Yolk Sac Tumor AJCC v6 and v7|Stage IV Ovarian Choriocarcinoma|Stage IV Ovarian Embryonal Carcinoma AJCC v6 and v7|Stage IV Ovarian Yolk Sac Tumor AJCC v6 and v7|Testicular Mixed Choriocarcinoma and Embryonal Carcinoma|Testicular Mixed Choriocarcinoma and Teratoma|Testicular Mixed Choriocarcinoma and Yolk Sac Tumor
Interventions: OTHER: Best Practice|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|BIOLOGICAL: Bleomycin Sulfate|DRUG: Carboplatin|DRUG: Cisplatin|PROCEDURE: Computed Tomography|DRUG: Etoposide|PROCEDURE: Magnetic Resonance Imaging|OTHER: Pharmacogenomic Study|PROCEDURE: Pulmonary Function Test|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY2189265 in Japanese Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: LY2189265|DRUG: Sulfonylureas (SU)|DRUG: Biguanides (BG)|DRUG: alpha-glucosidase inhibitor (a-GI)|DRUG: Thiazolidinedione (TZD)|DRUG: Glinides
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-center Study of VAL-083 in Patients With Recurrent Platinum Resistant Ovarian Cancer
Status: WITHDRAWN
Conditions: Ovarian Cancer
Interventions: DRUG: VAL-083, Dianhydrogalactitol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Age-dependent Effects of Flavanols on Vascular Status
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DIETARY_SUPPLEMENT: Flavanol rich intervention|DIETARY_SUPPLEMENT: Flavanol free control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Vemurafenib (Zelboraf) in Chinese Participants With BRAF V600 Mutation-Positive Unresectable or Metastatic Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: DRUG: Vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydromorphone vs Fentanyl in Children Undergoing Tonsillectomy Surgery
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Tonsillitis
Interventions: DRUG: Hydromorphone|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SierraSil Joint Formula 14 as an Ergogenic Aid to Performance in Athletes
Status: COMPLETED
Conditions: Muscle Power|Muscle Fatigue
Interventions: DIETARY_SUPPLEMENT: SierraSil|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Second-generation Sequencing Guides the Treatment of Severe Pneumonia
Status: UNKNOWN
Conditions: Pneumonia|Metagenomic Next Generation Sequencing
Interventions: DIAGNOSTIC_TEST: metagenomic next generation sequencing|DIAGNOSTIC_TEST: Conventional pathogen detection|DRUG: Meropenem，Imipenem，Caspofene，Osstat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of N-acetylcysteine to Prevent Anti-tuberculosis Drug-induced Liver Injury: A Randomized Controlled Trial
Status: RECRUITING
Conditions: Tuberculosis|Drug Induced Liver Injury|Hepatitis
Interventions: DRUG: N acetyl cysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Accelerated Theta Burst in Treatment-Resistant Depression: A Dose Finding and Biomarker Study
Status: ENROLLING_BY_INVITATION
Conditions: Treatment Resistant Depression
Interventions: DEVICE: Intermittent theta-burst stimulation (iTBS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epicardial Fat and Clinical Outcomes After Coronary Artery Bypass Grafting in Diabetics vs. Non Diabetics
Status: UNKNOWN
Conditions: Diabetes|Coronary Artery Disease
Interventions: DRUG: Incretins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Home-based Transcranial Direct Current Stimulation (tDCS) for Behavioral Symptoms in Alzheimer's Disease and Related Dementias (ADRD)
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DEVICE: active tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Clinical Study of the Efficacy and Safety of Two Low-concentration Atropine Sulfate Eye Drops
Status: ACTIVE_NOT_RECRUITING
Conditions: Myopia
Interventions: DRUG: Lower dose atropine sulfate eye drops|DRUG: Low dose atropine sulfate eye drops|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mucosal Impedance in Pediatric Population
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease (GERD)|Eosinophilic Esophagitis (EoE)|Functional Dyspepsia
Interventions: DIAGNOSTIC_TEST: Standard of Care esophagogastroduodenoscopy (EGD) with measurement of mucosal impedance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SLC13A5 Deficiency Natural History Study - Remote Only
Status: ENROLLING_BY_INVITATION
Conditions: Citrate Transporter Deficiency|Epilepsy|Rare Diseases|Movement Disorders|Genetic Disorder|SLC13A5 Deficiency|EIEE25|Kohlschutter-Tonz Syndrome (Non-ROGDI)|17p13.1 Deletions Confined to SLC13A5 Gene|Citrate Transporter Disorder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: KLEx Versus FS-LASIK for the Treatment of Myopia and Compound Myopic Astigmatism
Status: NOT_YET_RECRUITING
Conditions: Myopia|Astigmatism|Myopic Astigmatism
Interventions: PROCEDURE: FS-LASIK procedure|PROCEDURE: KLEx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effects of a Topically Applied Cream to Clitoral Blood Flow
Status: UNKNOWN
Conditions: Female Sexual Dysfunction
Interventions: DRUG: arginine 20%, nicotinamide .01%, niacin.1%, in LipodermPG 50%|DRUG: Topical study cream|DRUG: GRAS cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on the Safety of and Immune Response to Different Doses of an mRNA-based RSV Investigational Vaccine in Healthy Adults Aged 18-45 Years
Status: NOT_YET_RECRUITING
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: Investigational RSV vaccine 1|BIOLOGICAL: Investigational RSV vaccine 2|BIOLOGICAL: Investigational RSV vaccine 3|BIOLOGICAL: Investigational RSV vaccine 4|BIOLOGICAL: Investigational RSV vaccine 5|BIOLOGICAL: Investigational RSV vaccine 6|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Paracetamol and Mannitol Injection on Postoperative Analgesia in Patients With Thoracoscopic Lobectomy
Status: NOT_YET_RECRUITING
Conditions: Postoperative Analgesia
Interventions: DRUG: Paracetamol and Mannitol Injection|DRUG: Parecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of WIN-901X in Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: WIN-901X dose level 1|DRUG: WIN-901X dose level 2|DRUG: WIN-901X dose level 3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Droxidopa When Measuring Gait Speed, Kyphosis, and Functional Reach in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: droxidopa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inspiratory Muscle Training on The Severity of Exercise-Induced Bronchoconstriction and Time-Trial Performance (IMT_EIB)
Status: RECRUITING
Conditions: Exercise Induced Bronchospasm|Exercise Induced Asthma
Interventions: DEVICE: PrO2Fit Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: ICG vs. HSI in Gastrointestinal Resections
Status: UNKNOWN
Conditions: Anastomosis|Perfusion
Interventions: DIAGNOSTIC_TEST: Hyperspectral-Imaging|DIAGNOSTIC_TEST: Indocyaningreen-Fluorescence imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: BOTOX® in the Treatment of Crow's Feet Lines in Japan
Status: COMPLETED
Conditions: Lateral Canthus Rhytides|Crow's Feet Lines
Interventions: BIOLOGICAL: botulinum toxin Type A (24 U)|BIOLOGICAL: botulinum toxin Type A (12 U)|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Carotid B-Mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrpib/Atorvastatin to Atorvastatin Alone.
Status: COMPLETED
Conditions: Hypercholesterolemia, Familial|Hyperlipidemia
Interventions: DRUG: torcetrapib/atorvastatin|DRUG: atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Open-Label, Randomised, Active Controlled, Multi-Centre Phase 3 Study Safety and Efficacy of Danaparoid vs Argatroban
Status: TERMINATED
Conditions: Heparin-induced Thrombocytopenia
Interventions: DRUG: Danaparoid Sodium|DRUG: Argatroban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Interest of the Medical Device Called "Fluobeam" in the Localization, Visualization of the Parathyroid Glands for Patients With Mild Primary Hyperparathyroidism
Status: COMPLETED
Conditions: Mild Primary Hyperparathyroidism
Interventions: DEVICE: Use of the camera "Fluobeam"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluating Bundling of Nutrition-specific Interventions
Status: COMPLETED
Conditions: Stunting in Under-2 Children
Interventions: BEHAVIORAL: Nutrition-specific Behaviour change communication (BCC)|DIETARY_SUPPLEMENT: Nutrient supplement to pregnant women (PNS)|DIETARY_SUPPLEMENT: Nutrienr supplement to children 6m to 2 years
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TREXIMET (Formerly Known as TREXIMA) for the Acute Treatment of Probable Migraine (ICHD-II 1.6.1)
Status: COMPLETED
Conditions: Migraine, Without Aura
Interventions: DRUG: sumatriptan succinate / naproxen sodium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related Infection
Status: WITHDRAWN
Conditions: Cancer
Interventions: DRUG: Heparin|DRUG: Minocycline-EDTA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery
Status: RECRUITING
Conditions: Anosmia|Skull Base Neoplasms
Interventions: OTHER: Olfactory training|OTHER: Placebo training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Subcutaneous Ocaratuzumab in Patients With Previously Treated CD20+ B-Cell Malignancies
Status: UNKNOWN
Conditions: Previously Treated CD20+ B-cell Malignancies
Interventions: BIOLOGICAL: ocaratuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Chan-Chuang Qigong on Fatigue, Exercise Capacity and Quality of Lifpatients With Heart Failure
Status: COMPLETED
Conditions: Heart Failure NYHA Class II
Interventions: BEHAVIORAL: Chan-Chuang qigong
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I/II Study of Tivozanib and Erlotinib as Initial Treatment for Metastatic Non-small Cell Lung Cancer Assigned by VeriStrat® Serum Proteomic Evaluation
Status: WITHDRAWN
Conditions: Non-small Cell Lung Cancer|Stage IV Disease|EGFR Unknown or Wild-type
Interventions: DRUG: Tivozanib|DRUG: Erlotinib|OTHER: Standard of Care treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Frontal-Striatal Reward Circuit Neuromodulation and Alcohol Self-Administration
Status: TERMINATED
Conditions: Alcohol Use Disorder
Interventions: DEVICE: Low frequency repetitive transcranial magnetic stimulation (rTMS)|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: APC-111 MP Tablet Once a Day vs.Penicillin VK Four Times a Day Both for 10 Days in Patients With Strep Throat
Status: COMPLETED
Conditions: Sore Throat|Pharyngitis|Tonsillitis
Interventions: DRUG: APC-111 MP Tablet, 775 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Vorinostat With Doxil and Bortezomib for Patients With Relapsed/Refractory Multiple Myeloma
Status: WITHDRAWN
Conditions: Multiple Myeloma
Interventions: DRUG: Vorinostat|DRUG: Bortezomib|DRUG: pegylated liposomal doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PD-1 Antibody and Lenvatinib Plus TACE on Downstaging BCLC B/C HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: COMBINATION_PRODUCT: PD-1 and Lenvatinib Plus TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Ranibizumab for Edema of the mAcula in Diabetes-2 (READ-2) Study
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Ranibizumab|PROCEDURE: Laser photocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Translumbosacral Neuromodulation for FI
Status: RECRUITING
Conditions: Fecal Incontinence
Interventions: DEVICE: Translumbosacral Neuromodulation Therapy (TNT)|OTHER: Sham TNT Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate Safety and pK Profile of Metformin Glycinate in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Step A: metformin glycinate 620 mg single dose|DRUG: Step A: metformin glycinate 1240 mg single dose|DRUG: Step A: metformin glycinate 2480 mg single dose|DRUG: Step A: metformin hydrochloride 1000 mg single dose|DRUG: Step A: metformin glycinate 1240 mg,food intake|DRUG: Step B: metformin glycinate 620 mg BID|DRUG: Step B: metformin hydrochloride 500 mg BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-pharmacological Treatments for Non-malignant and Malignant Pain
Status: UNKNOWN
Conditions: Comparison of Treatment for Chronic Non-malignant and Malignant Pain
Interventions: BEHAVIORAL: Self-hypnosis/self-care|BEHAVIORAL: Music/self-care|BEHAVIORAL: Self-hypnosis/self-care motivation|BEHAVIORAL: Self-hypnosis/self-care malignant pain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Compare the Pharmacokinetics (PK) of Single Subcutaneous (SC) Injections of Vedolizumab Administered in Prefilled Syringe (PFS) Versus (vs) Prefilled Syringe in Needle Safety Device (PFS+NSD) in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Vedolizumab SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dietary Choice in Active Older Adult Women
Status: COMPLETED
Conditions: Exercise Addiction|Diet Habit|Obesity|Overweight|Weight Loss
Interventions: DIETARY_SUPPLEMENT: NCDsport|DIETARY_SUPPLEMENT: LCDsport
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Stop or Ongoing Oral Anticoagulation in Patients Undergoing Pvp (SOAP)
Status: RECRUITING
Conditions: Benign Prostatic Hyperplasia|Anticoagulant Adverse Reaction
Interventions: OTHER: Maintenance of OAC in surgery of BPH by PVP.|OTHER: Discontinuation of OAC in surgery of BPH by PVP.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Assess Objective Endpoint Measurements of Response in Bacterial Skin Infections
Status: COMPLETED
Conditions: Skin and Subcutaneous Tissue Bacterial Infections
Interventions: DRUG: Delafloxacin|DRUG: Linezolid|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: rTMS and Retraining in Focal Hand Dystonia
Status: COMPLETED
Conditions: Focal Dystonia
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation|BEHAVIORAL: Sensorimotor Retraining|BEHAVIORAL: Non-specific Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study on the Analysis of Risk Factors for the Occurrence of PD-1/PD-L1 Inhibitor-associated Liver Injury in Lung Cancer Patients
Status: RECRUITING
Conditions: Immune Checkpoint Inhibitors|Liver Injury
Interventions: OTHER: High risk prediction model for liver injury
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Amlodipine Prevents Morning Blood Pressure Surge Study
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Amlodipine (Norvasc®)|DRUG: Nifedipine GITS (Adalat® XL 30
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial of "Magic Gyno" Laser Device
Status: COMPLETED
Conditions: Female Urogenital Diseases|Urinary Incontinence|Prolapse Genital|Menopausal Syndrome|Postmenopausal Period|Vaginal Atrophy|Vaginal Prolapse|Postpartum Period|Sexual Dysfunction|Preoperative Care|Postoperative Care
Interventions: DEVICE: Laser treatment|DIAGNOSTIC_TEST: Blood test|DIAGNOSTIC_TEST: Clinical urine test|DIAGNOSTIC_TEST: Vaginal smear|DIAGNOSTIC_TEST: Pelvic ultrasound|OTHER: Female Sexual Function Index|OTHER: International Consultation on Incontinence Questionnaire - Short Form|OTHER: The Short Form Health Survey|DIAGNOSTIC_TEST: Vaginal Health Index|DIAGNOSTIC_TEST: Vital signs determination|DIAGNOSTIC_TEST: pH of vagina determination|DIAGNOSTIC_TEST: Physical parameters determination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetics Profiles of HQP1351 Under Fasting and High-fat Meals in Patients With Chronic Myeloid Leukemia
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia, Chronic Phase
Interventions: DRUG: HQP1351
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT