pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Dextrose Effect on Postoperative Nausea and Vomiting (PONV)
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: OTHER: Dextrose 5% in water|OTHER: Dextrose 10%|OTHER: Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Adherence to Low Tidal Volume in the Transition to Spontaneous Ventilation in Patients With Acute Respiratory Failure
Status: RECRUITING
Conditions: Respiration, Artificial|Acute Hypoxemic Respiratory Failure|Respiratory Insufficiency
Interventions: OTHER: Spontaneous mode of mechanical ventilation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Boceprevir With Peginterferon Alfa-2b and Ribavirin in the Treatment-naive Patients Infected With Genotype 4 Chronic Hepatitis C Infection
Status: UNKNOWN
Conditions: Genotype 4 Chronic Hepatitis C Infection
Interventions: DRUG: Boceprevir|DRUG: Peginterferon alfa-2b|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predicting Peanut Anaphylaxis and Reducing Epinephrine
Status: RECRUITING
Conditions: Anaphylaxis Food
Interventions: DEVICE: Transepidermal water loss (TEWL) monitor and stopping rules|DEVICE: Monitor (TEWL) without stopping rules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate Safety and Efficacy of DB-020 to Protect Hearing in Patients Receiving Cisplatin for Cancer Treatment
Status: COMPLETED
Conditions: Ototoxicity
Interventions: DRUG: DB-020|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Factorial Trial Investigating Outcome and Adherence Relevant Factors in an Online Self-help Intervention for Depression
Status: COMPLETED
Conditions: Depression Mild|Depression Moderate
Interventions: BEHAVIORAL: HERMES (Online Self-Help Intervention based on problem-solving therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: 7 cm vs. 5 cm Pancreatic Stents for the Prevention of Post-ERCP Pancreatitis in High-risk Patients
Status: UNKNOWN
Conditions: Post-ERCP Acute Pancreatitis
Interventions: DEVICE: 5cm 5-Fr PDS|DEVICE: 7cm 5-Fr PDS|DRUG: Indomethacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Efficacy and Safety of the Combination of Valturna and Amlodipine or Valturna and Chlorthalidone Versus Valturna Alone in Patients With Stage 2 Hypertension and Diabetes
Status: TERMINATED
Conditions: Hypertension|Stage 2 Hypertension|Diabetes
Interventions: DRUG: Valturna|DRUG: Amlodipine|DRUG: Chlorthalidone|DRUG: Placebo of Valturna Tablet|DRUG: Placebo Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Sympathetic Plexus Block on Male Pelvic Pain (Prostatitis, Prostatodynia)
Status: SUSPENDED
Conditions: Chronic Male Pelvic Pain Syndrome|Prostatitis
Interventions: PROCEDURE: nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Immunotherapy With Herceptin and the HER2 Vaccine NeuVax
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Herceptin|DRUG: NeuVax vaccine|DRUG: GM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: RCT, Proof of Concept Study of TEAMS (Training Executive, Attention and Motor Skills) Intervention Program
Status: UNKNOWN
Conditions: ADHD|Attention Deficit Disorder With Hyperactivity
Interventions: BEHAVIORAL: TEAMS intervention|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fractional Laser-assisted Daylight Photodynamic Therapy Versus Daylight Photodynamic for Treatment of Actinic Keratoses
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: PROCEDURE: Pretreatment with CO2 laser before photodynamic therapy|DEVICE: Only photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Correlation Analysis Between Corneal Biomechanics and Anterior Segment
Status: COMPLETED
Conditions: Ciliary Muscle Thickness|Anterior Sclera Thickness|Corneal Biomechanics|CASIA2
Interventions: OTHER: Pentacam, Corvis ST and Casia2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Evaluating Cemiplimab Alone and Combined With RP1 in Treating Advanced Squamous Skin Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cutaneous Squamous Cell Carcinoma|Advanced Cutaneous Squamous Cell Carcinoma|Metastatic Cutaneous Squamous Cell Carcinoma
Interventions: DRUG: Cemiplimab|BIOLOGICAL: RP1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-Arm Phase II Exploratory Clinical Study of Pemigatinib in the Treatment of Advanced Gastric and Colorectal Cancer Patients With FGFR Alterations Who Have Failed Standard Therapy
Status: RECRUITING
Conditions: Gastric and Colorectal Cancer
Interventions: DRUG: pemigatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab & Pertuzumab Followed by T-DM1 in MBC
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Trastuzumab|DRUG: Pertuzumab|DRUG: Paclitaxel|DRUG: Vinorelbine|DRUG: T-DM1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Pulmonary Dysfunction in Childhood Cancer Patients
Status: RECRUITING
Conditions: Pulmonary Dysfunction
Interventions: DIAGNOSTIC_TEST: Lung function measurements|DIAGNOSTIC_TEST: Breath Analysis|DIAGNOSTIC_TEST: Magnetic resonance imaging (MRI)|OTHER: Standardized interview to assess respiratory symptoms|OTHER: Data collection for assessment of clinical parameters and cumulative doses to chemotherapy, radiation, surgery and HSCT|OTHER: Collection of genetic samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adductor Canal Blocks With Bupivacaine and Magnesium After Same-day Discharge Total Knee Arthroplasty Improve Post-operative Pain Relief and Decrease Opioid Consumption: a Prospective Randomized Controlled Trial
Status: COMPLETED
Conditions: Post-operative Pain, Acute
Interventions: DRUG: Adding Magnesium as an adjuvant to the adductor canal Block (ACB) for same-day discharge total knee arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dimenydrinate vs Ondansetron for PONV (DONV)
Status: COMPLETED
Conditions: PONV in Laparoscopic Cholocystectomies
Interventions: DRUG: Dimenhydrinate Tablets|DRUG: Ondansetron iv
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I Chemoprevention Trial With Green Tea Polyphenon E & Erlotinib in Patients With Premalignant Lesions of the Head & Neck
Status: COMPLETED
Conditions: Cancer of Head and Neck|Neoplasms, Head and Neck
Interventions: DRUG: Erlotinib|DIETARY_SUPPLEMENT: Green Tea Polyphenon E
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Post Marketing Surveillance of Alesion® in Japanese Paediatric Patients With Allergic Rhinitis, Eczema/Dermatitis, Urticaria and Pruritus
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial
Interventions: DRUG: Alesion®
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neurovascular Regulation During Exercise in Humans With Chronic Kidney Disease: Sympatholysis in CKD
Status: RECRUITING
Conditions: Chronic Kidney Disease
Interventions: DRUG: Sodium Bicarbonate|BEHAVIORAL: Exercise Training|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immune Checkpoint Blockade Therapy Using 18F-FLT PET/CT
Status: RECRUITING
Conditions: Cancer
Interventions: DEVICE: FDG PET/CT|DEVICE: FLT PET/CT|DEVICE: PET/MR|DRUG: [F-18] flurothymidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Feasibility of Irradiation and Nivolumab in Esophageal Cancer (INEC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophageal Cancer
Interventions: DRUG: Nivolumab|RADIATION: Radiotherapy|DRUG: Chemotherapy|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parecoxib as an Adjuvant to Scalp Nerve Blocks for Relief of Post-craniotomy Pain
Status: UNKNOWN
Conditions: Pain, Postoperative|Neurosurgery
Interventions: DRUG: Scalp blocks with ropivacaine plus parecoxib|DRUG: Scalp blocks with ropivacaine and intravenous parecoxib|DRUG: Scalp blocks with ropivacaine and intravenous saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sentinel Node in Larynx and Pharynx Cancers
Status: COMPLETED
Conditions: Head and Neck Cancer|Lymph Node Metastases
Interventions: PROCEDURE: Radioactive tracer injection via flexible endoscopy and SPECT scan for visualization of lymph nodes.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of PRO95780 Administered in Combination With the FOLFOX Regimen and Bevacizumab in Patients With Previously Untreated, Locally Advanced, Recurrent, and Metastatic Colorectal Cancer (APM4566g)
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: bevacizumab|DRUG: FOLFOX|DRUG: PRO95780
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Disorders and Risk Factors in Childhood Cranial and Craniospinal Tumors Survivors
Status: COMPLETED
Conditions: Tumors of the Central Nervous System|Childhood Cancer Survivors
Interventions: DIAGNOSTIC_TEST: 12-lead ECG, hormone and lipid blood tests, echocardiography (Echo-CG), cardiopulmonary exercise testing (CPET) and pulse wave analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of ATG to Thymoglobuline in Renal Transplantation
Status: COMPLETED
Conditions: Transplantation, Kidney
Interventions: DRUG: ATG Fresenius|DRUG: Thymoglobuline Genzyme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breastfeeding, Antiretroviral, and Nutrition Study
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Maternal zidovudine/lamivudine/lopinavir-ritonavir|DRUG: Infant nevirapine|DIETARY_SUPPLEMENT: Maternal protein and calorie supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Constraint-induced Therapy for the Scapular Kinematics in Patients With Severe Chronic Hemiparesis
Status: UNKNOWN
Conditions: Stroke
Interventions: OTHER: Constraint Induced Therapy|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study in Subjects With Diabetic Neuropathic Pain
Status: COMPLETED
Conditions: Diabetic Neuralgia|Diabetic Neuropathies|Diabetic Neuropathy, Painful|Diabetic Polyneuropathy|Neuralgia, Diabetic
Interventions: DRUG: ABT-894|DRUG: ABT-894|DRUG: ABT-894|DRUG: placebo|DRUG: Duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Doxorubicin Hydrochloride Liposome as First-Line Therapy in Treating Older Women With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: pegylated liposomal doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sustained Oral Fiber Supplementation for Patients Undergoing Donor Stem Cell Transplantation for Hematological Malignancies
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm
Interventions: DIETARY_SUPPLEMENT: Kate Farms 1.0|DIETARY_SUPPLEMENT: Standard of Care Nutritional Support|OTHER: Survey Administration|DIETARY_SUPPLEMENT: Dietary Supplement|PROCEDURE: Biospecimen Collection|OTHER: Electronic Health Record Review|OTHER: Fiber and Dietary Assessments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Use of Caudal Anesthesia Supplemented With Morphine in Children Undergoing Renal Surgery
Status: COMPLETED
Conditions: Anesthesia, Caudal
Interventions: DRUG: caudal anesthesia|DRUG: caudal anesthesia supplemented with morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: SedestActiv Project: Intervention to Reduce Diary Hours of Sitting Time in Overweight and Obese Patients
Status: UNKNOWN
Conditions: Overweight|Obese|Sedentary
Interventions: BEHAVIORAL: Sitting time Change Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Predictive Values of Plasma Soluble RAGE Levels and RAGE Polymorphisms for the Onset of Acute Respiratory Distress Syndrome in Critically Ill Patients
Status: COMPLETED
Conditions: Intensive Care Unit|Population at High Risk for ARDS Development
Interventions: OTHER: sRAGE
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pilot Study to Assess the Efficacy of NEOX® CORD 1K® in the Treatment of Complex Diabetic Wounds
Status: WITHDRAWN
Conditions: Vascular Ulcer (Arterial or Venous Including Diabetic Ulcers Not Located on the Foot)|Diabetic Foot Ulcer|Diabetic Foot|Diabetic Foot Infection|Diabetic Foot Ulcer Mixed
Interventions: BIOLOGICAL: NEOX® CORD 1K®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tadalafil for Pulmonary Hypertension Due to Chronic Lung Disease
Status: COMPLETED
Conditions: Pulmonary Hypertension|Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Tadalafil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term outcomeS of cavotrIcuspid isthMus-dePendent fLuttEr Ablation: Single vs Double Catheter Procedure
Status: COMPLETED
Conditions: Atrial Flutter
Interventions: PROCEDURE: Single catheter approach|PROCEDURE: Traditional approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of Subcutaneously Administered Treprostinil Sodium in Patients With Severe (Non-operable) Chronic Thromboembolic Pulmonary Hypertension (CTREPH)
Status: COMPLETED
Conditions: Non-operable Chronic Thromboembolic Pulmonary Hypertension
Interventions: DRUG: Treprostinil sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of NTRX-07 in Healthy Volunteers
Status: COMPLETED
Conditions: Pain, Neuropathic
Interventions: DRUG: NTRX-07-SDD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Elbow Hemiarthroplasty Versus Total Elbow Arthroplasty for Irreparable Distal Humeral Fractures
Status: COMPLETED
Conditions: Distal Humerus Fracture
Interventions: PROCEDURE: Elbow Hemiarthroplasty|PROCEDURE: Total Elbow Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of PNF Training for Improving for Muscle Strength, Function, and Pain After Axillary Lymph Node Dissection
Status: COMPLETED
Conditions: Breast Cancer|Muscle Strength
Interventions: OTHER: Proprioceptive Neuromuscular Rehabilitation group|OTHER: Progressive Resistance Exercise Group|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Injection of CD4 and CD8 + T Cells Anti-Cytomegalovirus (CMV) or Anti-adenovirus
Status: COMPLETED
Conditions: Cytomegalovirus Infections|Adenovirus Infections
Interventions: OTHER: Cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Combination Therapies With or Without Pembrolizumab (MK-3475) and/or Chemotherapy in Participants With Advanced Esophageal Cancer (MK-3475-06A)
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma (ESCC)
Interventions: BIOLOGICAL: Pembrolizumab|BIOLOGICAL: Coformulation favezelimab/pembrolizumab|BIOLOGICAL: MK-4830|DRUG: Lenvatinib|DRUG: Irinotecan|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Estrogen Supplementation and Bone Health in Women With CF
Status: RECRUITING
Conditions: Cystic Fibrosis|Hypoestrogenism
Interventions: DRUG: Transdermal estrogen|DRUG: Progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deep Transcranial Magnetic Stimulation (dTMS) for the Treatment of Premenstrual Dysphoric Disorder (PMDD)
Status: UNKNOWN
Conditions: Premenstrual Dysphoric Disorder
Interventions: DEVICE: dTMS H-coil system:magstim stimulator rapid2,BrainswayH1coil|DEVICE: Sham: dTMS H-coil system:magstim stimulator rapid2,BrainswayH1coil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab Plus CA-4948 for the Treatment of Patients With Progressive Metastatic Urothelial Cancer Despite Prior Immunotherapy
Status: NOT_YET_RECRUITING
Conditions: Metastatic Urothelial Carcinoma|Unresectable Urothelial Carcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|BIOLOGICAL: Emavusertib|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Pembrolizumab|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Infant Calming Education on Maternal Role Perception, Maternal Attachment and Breastfeeding Self-Efficacy
Status: COMPLETED
Conditions: Infant Development
Interventions: BEHAVIORAL: Infant Calming Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Dose-Finding Study of Subcutaneous Herceptin (Trastuzumab) in Healthy Male Volunteers and Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Females
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Herceptin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ribavirin 200 mg Tablets Under Non-Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ribavirin 200 mg tablets|DRUG: COPEGUS™ 200 mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Intraoperative Usage of Sentinella in Detecting Sentinel Lymph Nodes
Status: COMPLETED
Conditions: Melanoma|Head and Neck Cancer|Breast Cancer
Interventions: DEVICE: Sentinella Intraoperative imaging protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Agili-C Biphasic Implant in the Knee Joint
Status: COMPLETED
Conditions: Cartilage Diseases|Osteochondritis Dissecans
Interventions: DEVICE: Agili-C Bi-phasic Implant|PROCEDURE: mini-arthrotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MK-8527 Single-Dose Trial in HIV-1 Infected Participants (MK-8527-004)
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: MK-8527
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: e- Ab Sensor-based Real-time Detection of Mutant EGFR in Clinical Specimens From Patients of Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: DEVICE: Electrosensing antibody probing system (e- Ab sensing)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: TheraGauze™ Alone and Regranex®Gel 0.01% Plus TheraGauze™ in the Treatment of Wagner Stage I Diabetic Foot Ulcers
Status: UNKNOWN
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: TheraGauze|DRUG: Regranex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Split-Face Prospective Study Comparing Botox to Xeomin for the Treatment of Facial Wrinkles
Status: COMPLETED
Conditions: Facial Wrinkles
Interventions: DRUG: Xeomin to right side of face in half of the subjects; Xeomin to left side of face in the other half of subjects|DRUG: Botox to right side of face in half of the subjects (randomized); Botox to the left side of the face in the other half of subjects
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab With Bendamustine in Hodgkin Lymphoma
Status: RECRUITING
Conditions: Classical Hodgkin Lymphoma|Relapsed Cancer|Refractory Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Bendamustine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Mosunetuzumab, Polatuzumab, Tafasitamab, and Lenalidomide in Patients With Relapsed B-cell NHL
Status: RECRUITING
Conditions: Hodgkin Lymphoma|B-Cell Lymphoma|Relapsed B-cell NHL
Interventions: DRUG: Mosunetuzumab|DRUG: Polatuzumab vedotin|DRUG: Tafasitamab|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Gut Microbiota in Crohn's Disease Patients Suffering From Spondylarthritis
Status: UNKNOWN
Conditions: Crohn Disease|Spondyloarthritis
Interventions: OTHER: analysing microbiota
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Evaluating Multiple Doses Of ATN-103 In Subjects With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Active Rheumatoid Arthritis
Interventions: DRUG: ATN-103|DRUG: ATN-103|DRUG: ATN-103|DRUG: ATN-103|DRUG: ATN-103|DRUG: Placebo|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nutri-CAP: Nutrition for Children, Adolescent Girls, and Pregnant Women in Slums of Dhaka City
Status: UNKNOWN
Conditions: Gestational Weight Gain|Diet, Food, and Nutrition|Undernutrition|Health Behavior
Interventions: BEHAVIORAL: Experimental - Intensive nutrition counselling for pregnant, adolescent and under2 children
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of GZR18 Injection in Chinese Obese/Overweight Patients
Status: COMPLETED
Conditions: Obesity|Overweight
Interventions: DRUG: GZR18|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: OPT-302 With Aflibercept in Neovascular Age-related Macular Degeneration (nAMD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Neovascular Age-related Macular Degeneration
Interventions: BIOLOGICAL: 2.0 mg OPT-302|BIOLOGICAL: 2.0 aflibercept|PROCEDURE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Usefulness of GI-GENIUS in FIT-based Colorectal Cancer Screening Program.
Status: COMPLETED
Conditions: Colorectal Neoplasms|Intestinal Neoplasms|Gastrointestinal Neoplasms|Colonic Polyp|Colorectal Cancer|Adenoma Colon|Serrated Adenoma|Serrated Polyp
Interventions: DEVICE: GI-GENIUS Medtronic|OTHER: Colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Reaction Time and Postural Control in Individuals With Cystic Fibrosis and Bronchiectasis
Status: UNKNOWN
Conditions: Cystic Fibrosis|Bronchiectasis
Interventions: OTHER: Reaction Time and Postural Control|OTHER: Muscle oxygenation|OTHER: Exercise capacity|OTHER: Balance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment and Prevention of Caregiver Burden in Oncology
Status: NOT_YET_RECRUITING
Conditions: Oncology|Caregiver Burden
Interventions: OTHER: Specific nursing support|OTHER: Non-specific nursing support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study in End Stage Renal Disease (ESRD) Patients on Hemodialysis Comparing the Theranova Dialyzer to Hemodiafiltration
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DEVICE: Theranova 400 Dialyzer|DEVICE: FX800 Dialyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bicalutamide and Goserelin or Leuprolide Acetate With or Without Cixutumumab in Treating Patients With Newly Diagnosed Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostate Adenocarcinoma|Recurrent Prostate Carcinoma|Stage IV Prostate Cancer
Interventions: DRUG: Bicalutamide|BIOLOGICAL: Cixutumumab|DRUG: Goserelin Acetate|OTHER: Laboratory Biomarker Analysis|DRUG: Leuprolide Acetate|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abuse Potential of Buprenorphine and Naloxone in Non-Dependent Opioid Users
Status: COMPLETED
Conditions: Opioid-Related Disorders
Interventions: DRUG: Buprenorphine|DRUG: Buprenorphine and Naloxone|DRUG: Hydromorphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Full-spectrum Medical Cannabis for Treatment of Spasticity in Patients With Severe Forms of Cerebral Palsy
Status: COMPLETED
Conditions: Children, Adult|Spastic Cerebral Palsy|Quality of Life|Cannabis|Physical Disability
Interventions: DIAGNOSTIC_TEST: Lab tests|DIAGNOSTIC_TEST: ECG|DIAGNOSTIC_TEST: Cannabinoid Levels|DRUG: Full-spectrum Medical Canabis Product (HemPhar)|DRUG: Placebo|DIAGNOSTIC_TEST: Spasticity level according to modified Ashworth scale (Bohannon)|DIAGNOSTIC_TEST: Gross Motor Function Measure|DIAGNOSTIC_TEST: Borg rating of perceived exertion scale|DIAGNOSTIC_TEST: Edmonton symptom assessment system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Individual Nutrition in Preterm Very Low Birth Weight Infants
Status: COMPLETED
Conditions: Infant, Premature, Diseases|Infant, Small for Gestational Age
Interventions: DIETARY_SUPPLEMENT: Individualized Nutrition|DIETARY_SUPPLEMENT: Optimized nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Lumasiran in Adults With Recurrent Calcium Oxalate Kidney Stone Disease and Elevated Urinary Oxalate Levels
Status: TERMINATED
Conditions: Recurrent Calcium Oxalate Kidney Stone Disease|Elevated Urinary Oxalate Levels
Interventions: DRUG: Lumasiran|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Normal Saline Versus Heparin Intermittent Flushing for the Prevention of Occlusion in Port-a-Cath
Status: NOT_YET_RECRUITING
Conditions: Port-a-cath Occlusion|Normal Saline|Heparin Lock
Interventions: DRUG: Normal Saline Flush 20 ml|DRUG: Normal Saline Flush 10 ml|DRUG: Heparin Flush (1000 USP, 10ml)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: M4C Nutraceutical Intervention Human Health Effects Pilot
Status: NOT_YET_RECRUITING
Conditions: General Health and Wellness|Energy and Vitality|Cognitive Function and Mental Health|Weight Management|Digestive Health|Exercise Tolerance|Cardiovascular Health|Bone and Joint Health|Skin, Hair, and Nail Health|Immune Support|Sports Performance and Recovery|Sleep and Relaxation|Obesity|Anti Inflammatory
Interventions: DIETARY_SUPPLEMENT: M4C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation on Standardized Circuits of the Interest of a Robotic Module of Assistance to the Driving
Status: COMPLETED
Conditions: Neurological Disorders
Interventions: DEVICE: Electric wheelchair with activated assistance module|DEVICE: Electric wheelchair with assistance module not activated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study Comparing One Versus Two Cortisone Injections for Trigger Finger
Status: UNKNOWN
Conditions: Stenosing Tenosynovitis|Trigger Finger
Interventions: DRUG: One cortisone injection|DRUG: Two cortisone Injections
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Minimal Invasive Breast Cancer Excision Using Vacuum Assisted Biopsy Under Ultrasound Guidance
Status: RECRUITING
Conditions: Breast Cancer
Interventions: PROCEDURE: Vacuum assisted biopsy|PROCEDURE: conventional lumpectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Hemodynamic Safety of Two Common Alveolar Recruitment Manoeuvres With Regard to Cardiac Output in a Surgical Intensive Care Unit
Status: COMPLETED
Conditions: Positive-Pressure Respiration
Interventions: DEVICE: echocardiography|DEVICE: Arterial oximetry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Salivary Minerals in Patients With Peri-implantitis
Status: NOT_YET_RECRUITING
Conditions: Peri-Implantitis and Peri-implant Mucositis|Peri-implant Mucositis|Periimplant Bone Loss|Periimplant Diseases|Peri-implant Health
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: High Voltage VS Standard Voltage Radiofrequency in a Patient With Failed Back Surgery Syndrome
Status: RECRUITING
Conditions: Neuralgia|Failed Back Surgery Syndrome
Interventions: DEVICE: standard pulsed radio frequency (PRF)|DEVICE: high-voltage long-term pulsed radio frequency (PRF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Progressive Resistance Exercise Training on Endurance and Functional Mobility in Children With Spina Bifida
Status: COMPLETED
Conditions: Spina Bifida
Interventions: OTHER: Conventional treatment|OTHER: Progressive resistance exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Contrast-harmonic Endoscopic Ultrasound (CH-EUS) for the Diagnosis of Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma
Interventions: DRUG: SonoVue®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: QL vs LAI for Palatoplasty
Status: RECRUITING
Conditions: Post-operative Pain|Opioid Use|Cleft Palate
Interventions: PROCEDURE: Quadratus lumborum block|PROCEDURE: Local anesthetic infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A CLinical Study to Evaluate the Safety And Effectiveness of the CeRene DevIce to Treat HeavY Menstrual Bleeding
Status: COMPLETED
Conditions: Menorrhagia
Interventions: DEVICE: Cerene(R) Cryotherapy Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy, Holmium Ho 166 DOTMP, and Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: melphalan|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: holmium Ho 166 DOTMP
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of Nemtabrutinib in Participants With Moderate Hepatic Impairment (MK-1026-015)
Status: RECRUITING
Conditions: Hepatic Impairment (HI)
Interventions: DRUG: Nemtabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dynamic Management of Excess Residual Limb Pressure With New Smart Socket Technology/Intelligent Prosthetic Socket With Variable Volume and Elevated Vacuum Systems
Status: UNKNOWN
Conditions: Amputation
Interventions: DEVICE: adaptive prosthetic socket
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Role of Vitamin D in Immune Function in Patients With Chronic Kidney Disease (CKD) Stages 3 and 4.
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DIETARY_SUPPLEMENT: cholecalciferol|DIETARY_SUPPLEMENT: doxercalciferol|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Combination Caplet With Loperamide Hydrochloride and Simethicone, and Imodium Express Tablets-lyophilizate Coadministered With Espumisan Capsule in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Combination Caplet with Loperamide HCl and Simethicone|DRUG: Loperamide HCl|DRUG: Simethicone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Fenretinide in the Treatment of Geographic Atrophy Associated With Dry Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Geographic Atrophy|Dry Age Related Macular Degeneration
Interventions: DRUG: Fenretinide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stage I Randomized Trial of Mentalization-Based Therapy for Substance Using Mothers of Infants and Toddlers
Status: COMPLETED
Conditions: Maternal Substance Use|Child Abuse and Neglect
Interventions: BEHAVIORAL: Mentalizing Therapy for Substance Using Mothers|BEHAVIORAL: Standard Parent Education for Substance Using Mothers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Two Albiglutide Drug Products in Healthy Adult Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Albiglutide Liquid Auto-injector|DRUG: Albiglutide Lyophilized DCC Pen Injector|DRUG: Placebo Liquid Auto-injector|DRUG: Placebo Lyophilized DCC Pen injector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cerebellar Involvement in Cognitive Sequencing
Status: RECRUITING
Conditions: Effects of Cerebellar Stimulation on Brain Activation
Interventions: PROCEDURE: TMS during sequence-demanding task|PROCEDURE: No TMS during sequence-demanding task|PROCEDURE: TMS during non-sequence-demanding task|PROCEDURE: No TMS during non-sequence-demanding task
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neutrophil Oxidative Burst in Early and Late Onset Pediatric Inflammatory Bowel Disease
Status: RECRUITING
Conditions: Chronic Granulomatous Disease
Interventions: DIAGNOSTIC_TEST: Phagoburst|DIAGNOSTIC_TEST: Lymphocytes subsets|DIAGNOSTIC_TEST: Genetic testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of LY3200327 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Placebo (SC)|DRUG: LY3200327 (SC)|DRUG: LY3200327 (IV)|DRUG: Placebo (IV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neurodevelopmental Impact of Treatment in Hypothyroxinaemia of Prematurity.
Status: COMPLETED
Conditions: Transient Hypothyroxinemia of Prematurity
Interventions: DRUG: L-thyroxine at a dose of 7.5 µg/kg/d for THOP|OTHER: THOP without treatment|OTHER: NoTHOP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Engaging Patients in Prenatal Genetic Testing Decisions as a Pathway to Improve Obstetric Outcomes
Status: RECRUITING
Conditions: Prenatal Disorder
Interventions: BEHAVIORAL: Standard Care|BEHAVIORAL: Obstetric Prenatal Genetic Testing Engagement Solution (OPUS) AI Chatbot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of the Effect of the Time of Diagnosis (Antenatal vs. Postnatal) on the Post-traumatic Reactions of Parents of Children Undergoing Oesophageal Atresia Surgery "
Status: UNKNOWN
Conditions: Atresia, Esophageal
Interventions: OTHER: Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Telerehabilitation and Conventional Physiotherapy Program for Caregivers of Individuals With Special Needs
Status: NOT_YET_RECRUITING
Conditions: Telerehabilitation|Neck Pain
Interventions: OTHER: telerehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Bevacizumab Plus Carboplatin and Paclitaxel in Subjects With Advanced, Previously Untreated, Squamous Non-Small Cell Lung Cancer (BRIDGE)
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Bevacizumab|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of a Connected Companion in Children With Cystic Fibrosis
Status: UNKNOWN
Conditions: Cystic Fibrosis in Children|Chronic Disease
Interventions: DEVICE: Connected device named "Leo" from Ludocare society
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nicotinamide Riboside With and Without Resveratrol to Improve Functioning in Peripheral Artery Disease
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: DRUG: Nicotinamide riboside|DRUG: Resveratrol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Efficacy of MIW815 With PDR001 in Patients With Advanced/Metastatic Solid Tumors or Lymphomas
Status: TERMINATED
Conditions: Solid Tumors and Lymphomas
Interventions: DRUG: MIW815|BIOLOGICAL: PDR001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AScalate: Treat-to-target in Axial Spondyloarthritis
Status: COMPLETED
Conditions: Axial Spondyloarthritis
Interventions: BIOLOGICAL: Secukinumab/Adalimumab-Biosimilar|OTHER: Standard-of-care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Erector Spinae Plane Block or Thoracic Epidural Analgesia Following Video Assisted Thoracic Surgery
Status: COMPLETED
Conditions: Lung Diseases
Interventions: OTHER: ESP block (Group A)|OTHER: TEA group (Group B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Intravenous Lidocaine During Colorectal Surgery on Pain and Immune Functions
Status: RECRUITING
Conditions: Intravenous Lidocaine and Immunity
Interventions: DRUG: intravenous lidocaine (IVL)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lancovutide (Moli1901) Inhalation Solution Study in Adolescents and Adults With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Moli1901|DRUG: Moli1901 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BOTOX® (onabotulinumtoxinA) Treatment of Masseter Muscle Prominence
Status: COMPLETED
Conditions: Masseter Muscle Prominence
Interventions: BIOLOGICAL: OnabotulinumtoxinA|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Web-Based Social-Cognitive Interventions in Right Hemisphere Stroke and Frontotemporal Dementia
Status: COMPLETED
Conditions: Frontotemporal Dementia|Right Sided Cerebral Hemisphere Cerebrovascular Accident
Interventions: OTHER: Brain HQ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The PCI Choice Trial: a Pilot Randomized Trial of a Decision Aid for Patients With Stable Coronary Artery Disease
Status: COMPLETED
Conditions: Stable Angina
Interventions: OTHER: Decision Aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Drug-drug Interaction Study of HRS-1780 Tablets in Healthy Subjects
Status: NOT_YET_RECRUITING
Conditions: Chronic Kidney Disease(CKD)
Interventions: DRUG: HRS-1780 tablets; Itraconazole capsules; Rifampicin capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Different Dietary Fibers in Gastric Emptying Time and Intestinal Transit of Healthy Volunteers
Status: UNKNOWN
Conditions: Gastric Emptying|Intestinal Transit Time
Interventions: DIETARY_SUPPLEMENT: Soluble Dietary Fibers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Carboplatin Plus Irinotecan in Treating Patients With Glioblastoma Multiforme
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: carboplatin|DRUG: irinotecan hydrochloride|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT