pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Gait Initiation Difficulty and Anticipatory Postural Adjustment (APA) Impairment in People With PD - Evaluation and Training
Status: COMPLETED
Conditions: Parkinson Disease(PD)
Interventions: OTHER: Weight shift training and APA feedback|OTHER: Weight shift training without APA feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Care for Children With Congenital Heart Disease.
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Disease Congenital|Ventricular Septal Defect|Atrial Septal Defect|Patent Ductus Arteriosus|Partial Anomalous Pulmonary Venous Connection|Aortopulmonary Window|Cardiovascular Diseases
Interventions: DIAGNOSTIC_TEST: Biomarker analysis at enrolment|DIAGNOSTIC_TEST: Biomarker analyses throughout the study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Prospective Randomized Pilot Study Comparing Inferior Versus Superior Conjunctival Autografts for Primary Pterygia
Status: UNKNOWN
Conditions: Pterygium
Interventions: PROCEDURE: Location of the autograft taken following pterygium excision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CAR-20/19-T Cells in Patients With Relapsed Refractory B Cell
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin|Lymphoma, B-Cell|Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: BIOLOGICAL: CAR-20/19-T cells (1.0 x10^5 CAR-20/19-T cells/kg)|BIOLOGICAL: CAR-20/19-T cells (2.5 x10^5 CAR-20/19-T cells/kg)|BIOLOGICAL: CAR-20/19-T cells (7.5 x10^5 CAR-20/19-T cells/kg)|BIOLOGICAL: CAR-20/19-T cells (2.5 x10^6 CAR-20/19-T cells/kg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase IB/II Clinical Study of SHR-9839 for Injection Combined With Other Anti-tumor Therapies in Patients With Advanced Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: SHR-9839 ；SHR-A2009|DRUG: SHR-9839 ； SHR-A1921|DRUG: SHR-9839 ； pemetrexed ；carboplatin|DRUG: SHR-9839 ； Almonertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Peripheral Blood Progenitor Cell (PBPC) Mobilisation by Chemotherapy With Pegfilgrastim or Filgrastim in Subjects With Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: pegfilgrastim|DRUG: filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Contribution of Actigraphy and Recognition Video in Apathy Assessment of Alzheimer's Disease : Experimental Research
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: OTHER: Actigraphy and video recording signal
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cara CDRM (Conduction Disturbance Risk Monitor) 2.0
Status: ACTIVE_NOT_RECRUITING
Conditions: Transcatheter Aortic Valve Replacement
Interventions: OTHER: ECG monitoring for Conduction Disturbances
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Nivolumab in Treating Patients With Stage IIB-IIC Melanoma That Can Be Removed by Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Relaxation Technique for Behavioral Management of ADHD Children During Dental Treatment.
Status: UNKNOWN
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: BEHAVIORAL: Muscle Relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Switching Medication to Treat Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Risperidone|DRUG: Olanzapine|DRUG: Ziprasidone|DRUG: Quetiapine|DRUG: Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Serotonin Agonist Citalopram on Multimodal Esophageal Stimulation in Healthy Volunteers
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DRUG: Citalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Safety and Tolerability of IV Doses of BMS-906024 in Subjects With Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: BMS-906024
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventive Effect of Leg Wrapping Combined With Trendelenburg Position on Hypotension Induced by Propofol
Status: UNKNOWN
Conditions: Hypotension|Propofol
Interventions: DEVICE: leg wrapping with tension|PROCEDURE: Trendelenburg position|DEVICE: leg wrapping without tension|PROCEDURE: supine position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy Study on Symptomatic Control of Patient With Knee Osteoarthritis Between 0.0125% of Capsaicin to Placebo
Status: COMPLETED
Conditions: Osteoarthritis, Knee Joint|Capsicum
Interventions: DRUG: 0.0125% Capsaicin gel "CAPSIKA gel"|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adherence and Health Effects of Video Dance in Postmenopausal Women
Status: COMPLETED
Conditions: Post Menopausal
Interventions: BEHAVIORAL: videodance|BEHAVIORAL: Brisk Walking|BEHAVIORAL: delayed entry control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Open-label, Three-way Crossover Study to Evaluate the Relative Bioavailability of 200 mg Cenobamate Administered Orally
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Cenobamate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age
Status: RECRUITING
Conditions: Opioid Toxicity|Pupillary Miosis|Respiratory Depression
Interventions: DRUG: Remifentanil Hydrochloride|DEVICE: Pupillometry measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Preheated Composites Vs. Conventional Composites in Noncarious Cervical Lesions
Status: UNKNOWN
Conditions: Noncarious Cervical Lesions
Interventions: OTHER: Conventional composite resin (3M™ Filtek™ Z350 XT Universal Restorative)|OTHER: Preheated composite resin (3M™ Filtek™ Z350 XT Universal Restorative)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab-based Therapy in Previously Treated High Grade Neuroendocrine Carcinomas
Status: COMPLETED
Conditions: High Grade Malignant Neuroendocrine Carcinoma (Diagnosis)
Interventions: DRUG: Pembrolizumab|DRUG: Irinotecan|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Symptom Based Performance of Airway Clearance After Starting Highly Effective Modulators for Cystic Fibrosis (SPACE-CF)
Status: RECRUITING
Conditions: Cystic Fibrosis|Mucociliary Clearance Defect
Interventions: OTHER: Symptom driven performance of airway clearance|OTHER: Continuous daily performance of airway clearance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post Prandial Glucose (PPG) Study of Empagliflozin in Japanese Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo|DRUG: Empagliflozin|DRUG: Placebo|DRUG: Placebo|DRUG: Empagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Concomitant Use of PriLigy in Men Treated for Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction|Sexual Dysfunction
Interventions: DRUG: Placebo|DRUG: Dapoxetine|DRUG: PDE5I (phosphodiesterase-5 inhibitor)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D3 (Vit D3) Supplementation and T Cell Immunomodulation in Patients With Newly Diagnosed Operative Invasive Ductal Breast Carcinoma
Status: TERMINATED
Conditions: Newly Diagnosed Operative Invasive Ductal Breast Carcinoma Stage I-II
Interventions: DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TEENS Multi-site Trial
Status: RECRUITING
Conditions: Self-Injurious Behavior
Interventions: BEHAVIORAL: Emotion Regulation Individual Therapy for Adolescents (ERITA)|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block in Pediatric Lower Limb Surgery
Status: COMPLETED
Conditions: Efficacy of Erector Spinae Plane Block in Lower Limb Surgery in Pediatric
Interventions: PROCEDURE: erector spinae plane block|PROCEDURE: ultrasound guided caudal block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nomacopan (rVA576) in Transplant Associated Thrombotic Microangiopathy
Status: TERMINATED
Conditions: Thrombotic Microangiopathies
Interventions: DRUG: nomacopan (rVA576)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous vs Oral Acetaminophen in Postoperative Hip Fracture Adult Patients
Status: NOT_YET_RECRUITING
Conditions: Hip-fracture|Surgery
Interventions: DRUG: Intravenous (IV) acetaminophen + oral placebo|DRUG: Intravenous (IV) placebo plus oral acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Postoperative Incentive Spirometry on Pulmonary Function and Pulmonary Complications in Bariatric Surgery
Status: COMPLETED
Conditions: Obesity, Morbid|Complications of Bariatric Procedures|Pulmonary Atelectasis|Pneumonia
Interventions: DEVICE: Incentive spirometer|DEVICE: No incentive spirometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Potential Impact of Renal Impairment on the Pharmacokinetics and Safety of CPX-351
Status: COMPLETED
Conditions: Hematologic Malignancy|Acute Myeloid Leukemia|Acute Lymphocytic Leukemia|Acute Lymphoblastic Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: CPX-351|DRUG: CPX-351
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REVADE : Right Ventricular Function and Exercise in Left Ventricular Assist Device Patients : Echocardiographic Study
Status: COMPLETED
Conditions: Left Ventricular Assist Devices Patients
Interventions: OTHER: adding 2 cardiopulmonary exercise testings : peak oxygen consumption (VO2 max) and stress echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: The Immunogenicity and Safety Following a Heterologous Booster Dose of Recombinant SARS-CoV-2 Vaccine LYB001
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19|Vaccine Reaction
Interventions: BIOLOGICAL: LYB001|BIOLOGICAL: CoronaVac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess Tolerability, Safety, Pharmacokinetics and Effect of AZP2006 in Patients With PSP
Status: ACTIVE_NOT_RECRUITING
Conditions: Progressive Supranuclear Palsy
Interventions: DRUG: AZP2006 oral solution|DRUG: Placebo oral solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ubiquinol as a Metabolic Resuscitator in Post-Cardiac Arrest
Status: COMPLETED
Conditions: Cardiac Arrest
Interventions: DRUG: Ubiquinol|DIETARY_SUPPLEMENT: Ensure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Prospective Randomized Trial Comparing Gastrectomy, Metastasectomy Plus Systemic Therapy Versus Systemic Therapy Alone: GYMSSA Trial
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: Oxaliplatin|DRUG: Irinotecan|DRUG: 5-Fluorouracil|DRUG: Leucovorin|PROCEDURE: Gastrectomy and/or metastasectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thromboxane Receptor Antagonist to Improve Endothelial Cell Function
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases|Vascular Dilation
Interventions: DRUG: Ifetroban Sodium|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Insulin Aspart in Subjects With Type 1 or Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DRUG: soluble human insulin|DRUG: insulin aspart|DRUG: insulin NPH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Ethanol Ablation of Communicating Pancreatic Cystic Neoplasms
Status: WITHDRAWN
Conditions: Neoplasms, Cystic, Mucinous, and Serous|Pancreatic Neoplasms|Ultrasonography, Interventional
Interventions: PROCEDURE: EUS and/or ERCP with ethanol injections of pancreatic cyst
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation in TB Prevention
Status: COMPLETED
Conditions: Latent Tuberculosis
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol (vitamin D3)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Remimazolam Versus Propofol for Painless Abortion
Status: COMPLETED
Conditions: Anesthesia|Abortion Early
Interventions: DRUG: Remimazolam|DRUG: Propofol|DRUG: Esketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Blinded, Placebo-Controlled Study of the Safety and Pharmacokinetics of Single Doses of Intravenous Deferiprone in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Deferiprone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Phase II Trail of Chidamide ,Rituximab and Methotrexate in Lymphoma Patients
Status: UNKNOWN
Conditions: Central Nervous System Lymphoma
Interventions: DRUG: chidamide combined with rituximab and high-dose methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paroxetine/Bupropion in Depression With Suicide Attempt or Thoughts: fMRI Study
Status: COMPLETED
Conditions: Depression|Suicidal Ideation
Interventions: DRUG: Paroxetine CR for Major Depressive Episode|DRUG: Bupropion XL for Major Depressive Episode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ianalumab (VAY736) in Patients With Primary Immune Thrombocytopenia (ITP) Previously Treated With at Least Two Lines of Therapies
Status: RECRUITING
Conditions: Primary Immune Thrombocytopenia (ITP)
Interventions: BIOLOGICAL: Ianalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension Study to Evaluate Safety and Efficacy of Natalizumab in Japanese Participants With Relapsing-Remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing-Remitting Multiple Sclerosis|Multiple Sclerosis
Interventions: DRUG: natalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D Supplement on Disease Activity in SLE
Status: UNKNOWN
Conditions: Vitamin D Deficiency|Hypocalcemia|Hyperparathyroidism|Systemic Lupus Erythematosus (Disorder)
Interventions: DRUG: vitamin D2 ( calciferol )|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endovenous Corticosteroid Pulses in Moderate Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Methylprednisolone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Relative Effects of Olmesartan Medoxomil, Irbesartan and Valsartan on the Activity of the Blood Pressure Control System in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Olmesartan medoxomil|DRUG: Irbesartan|DRUG: Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy and Safety of Daprodustat Compared to Darbepoetin Alfa in Japanese Hemodialysis (HD)-Dependent Subjects With Anemia Associated With Chronic Kidney Disease (CKD)
Status: COMPLETED
Conditions: Anaemia
Interventions: DRUG: Daprodustat small|DRUG: Daprodustat small placebo|DRUG: Daprodustat large|DRUG: Daprodustat large placebo|DRUG: Darbepoetin alfa|DRUG: Darbepoetin alfa placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of iBreast, a Handheld Device to Detect Breast Abnormalities During Screening Visits for Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Screening
Interventions: OTHER: Clinical Breast exam (CBE)|DEVICE: iBreastExam device|DIAGNOSTIC_TEST: mammogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Drug-Drug Interaction Study of Itraconazole With GST-HG171/Ritonavir in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participant
Interventions: DRUG: GST-HG171/Ritonavir|DRUG: Itraconazole|DRUG: GST-HG171/Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess the Safety and Tolerability of Lucerastat in Subjects With Fabry Disease
Status: COMPLETED
Conditions: Fabry Disease
Interventions: DRUG: Lucerastat|DRUG: Enzyme replacement therapy (ERT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study on MD05 in Comparison With Open Flap Debridement in Patients Undergoing Periodontal Surgery
Status: UNKNOWN
Conditions: Alveolar Bone Loss|Periodontal Bone Loss
Interventions: DRUG: MD05 and open flap debridement|PROCEDURE: Open flap debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Combined Therapy With Red Yeast Rice and Low-dose Statin：Comparing With Standardized Statin
Status: RECRUITING
Conditions: Dyslipidemia|Atherosclerosis
Interventions: DRUG: Red yeast rice and atorvastatin|DRUG: Atorvastatin alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Lidocaine in Bariatric Surgery.
Status: UNKNOWN
Conditions: Morbid Obesity|Bariatric Surgery Candidate
Interventions: DRUG: Lidocaine|DRUG: isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Multi-Modality Quantitative Imaging for Evaluation of Response of Metastatic Prostate Cancer to Therapy
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: PROCEDURE: SPECT CT|DRUG: 18F-DCFPyL PET/CT|DRUG: 18F-NaF PET/CT|PROCEDURE: WB-MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessing Mucociliary Clearance and Airway Liquid Volume in the CF Airway
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: PROCEDURE: mucociliary clearance scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Assess the Relative Bioavailability of Pacritinib Following Oral Administration as Capsule and Solution Formulations in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: (Treatment A)|DRUG: (Treatment B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Safety and Efficacy of Paltusotine for the Treatment of Acromegaly (ACROBAT Evolve)
Status: COMPLETED
Conditions: Acromegaly
Interventions: DRUG: Paltusotine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pan Tumor Rollover Study
Status: RECRUITING
Conditions: Cancer
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab|DRUG: Cabozantinib|DRUG: Trametinib|DRUG: Relatlimab|DRUG: Nivolumab + Relatlimab|DRUG: Capecitabine|DRUG: Bevacizumab|DRUG: Temozolomide|DRUG: Rucaparib|DRUG: Daratumumab|DRUG: Regorafinib|DRUG: Leucovorin|DRUG: Fluorouracil|DRUG: Oxaliplatin|DRUG: Enzalutamide|DRUG: Sunitinib|DRUG: Pemetrexed|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Co-Administration Of Methotrexate And CP-690,550
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: CP-690,550 (tofacitinib)|DRUG: Methotrexate (MTX)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Unacylated Ghrelin to Improve FuncTioning in PAD: The GIFT Trial
Status: COMPLETED
Conditions: Peripheral Artery Disease|PAD|Peripheral Arterial Disease
Interventions: DRUG: unacelyated ghrelin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Establishment of Precise Diagnosis and Treatment System for Refractory Chronic Rhinosinusitis
Status: RECRUITING
Conditions: Sinusitis
Interventions: DRUG: Mometasone furoate nasal spray hormone|DRUG: Mometasone furoate nasal spray hormone + oral hormone|DRUG: Mometasone furoate nasal spray hormone + omalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Correlation Between LR-ACT and Anti Xa Activity During Endovascular Surgery Procedures. AXAES (Anti Xa vs ACT-LR in Endovascular Surgery)
Status: NOT_YET_RECRUITING
Conditions: Aortic Diseases|Arterial Disease|Thrombosis
Interventions: BIOLOGICAL: Anti Xa activity measurement.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety and Efficacy of ASP015K in Moderate to Severe Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: peficitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Expiratory Muscle Training in Bronchiectasis
Status: COMPLETED
Conditions: Bronchiectasis
Interventions: OTHER: EMST150 (Expiratory muscle training)|OTHER: Sham EMST150 (Expiratory muscle training)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of an Investigational Lipid Drop in Non-contact Lens Wearing Patients
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: 9618X investigational lipid eye drops|DEVICE: Blink® Tears
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preventive Treatment of OxaLiplatin Induced peripherAl neuRopathy in Adjuvant Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer|Chemotherapy-induced Peripheral Neuropathy
Interventions: DRUG: Calmangafodipir (5 µmol/kg)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Trastuzumab and Flavopiridol in Treating Patients With Metastatic Breast Cancer
Status: TERMINATED
Conditions: HER2-positive Breast Cancer|Male Breast Cancer|Recurrent Breast Cancer|Stage IV Breast Cancer
Interventions: BIOLOGICAL: trastuzumab|DRUG: alvocidib|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of HR18034 for Postoperative Analgesia in Subjects Undergoing Hemorrhoidectomy
Status: COMPLETED
Conditions: Postsurgical Pain Management
Interventions: DRUG: HR18034|DRUG: ropivacaine HCl|DRUG: Sodium Chloride Physiological Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Clinical Study of Treprilimab in the Treatment of Recurrent Nasopharyngeal Carcinoma After Re-irradiation
Status: NOT_YET_RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Treprilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gefitinib and Radiation Therapy in Treating Patients With Inoperable Stage I or Stage II Non-Small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: gefitinib|PROCEDURE: adjuvant therapy|PROCEDURE: enzyme inhibitor therapy|PROCEDURE: neoadjuvant therapy|PROCEDURE: protein tyrosine kinase inhibitor therapy|PROCEDURE: radiation therapy|PROCEDURE: radiosensitization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Remimazolam-based MAC With Inhalation General Anesthesia Under the Guidance of an ANI Monitor During TURB
Status: NOT_YET_RECRUITING
Conditions: Patients Undergoing Transurethral Resection of Bladder
Interventions: DRUG: remimazolam based MAC|DRUG: general anesthesia with sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Neoadjuvant Enfortumab Vedotin and Pembrolizumab in Cisplatin-eligible Upper Tract Urothelial Cancer
Status: NOT_YET_RECRUITING
Conditions: Urothelial Carcinoma
Interventions: DRUG: Enfortumab vedotin|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sentinel Node Detection in Endometrial Cancer: A Consolidation Study on Detection Rates of Metastatic Disease
Status: UNKNOWN
Conditions: Sentinel Lymph Node|Endometrial Cancer|Lymphedema
Interventions: PROCEDURE: Injection of tracer ( ICG) and detection of sentinel lymph nodes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Amlodipine/Benazepril in Reducing Left Ventricular Hypertrophy in Patients With High Risk Hypertension
Status: COMPLETED
Conditions: Hypertension|Left Ventricular Hypertrophy
Interventions: DRUG: amlodipine/benazepril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Access in General Surgery: the Closed (Veress Needle) Technique Versus the Open (Hasson) Technique
Status: COMPLETED
Conditions: Laparoscopic Surgery|Laparoscopic Entry Technique
Interventions: PROCEDURE: Laparoscopic peritoneal entry technique: Veress needle versus Hasson
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Survey of the Collective 16s rRNA Genes From Bacterial Populations From Exercising and Non-exercising Participants
Status: COMPLETED
Conditions: Dental Caries
Interventions: BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Beauty Image Efficacy Study
Status: COMPLETED
Conditions: Skin Aging
Interventions: DIETARY_SUPPLEMENT: Beauty Image|DIETARY_SUPPLEMENT: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ixabepilone in Treating Patients With Ovarian Epithelial or Primary Peritoneal Cancer That Has Not Responded to Previous Chemotherapy
Status: COMPLETED
Conditions: Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer
Interventions: DRUG: ixabepilone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Intensity Extracorporeal Shock Wave Therapy (Li-ESWT) for Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DEVICE: Low-Intensity Extracorporeal Shock Wave Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Title: Comparison of Anti-plaque Efficacy of Natural Honey With Chlorhexidine Mouthwash: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Dental Plaque
Interventions: OTHER: Natural honey|DRUG: Chlorhexidine mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Belinostat for Solid Tumors and Lymphomas in Patients With Varying Degrees of Hepatic Dysfunction
Status: COMPLETED
Conditions: Neoplasms|Lymphomas
Interventions: DRUG: Belinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study to Assess Disease Activity and Biomarkers in Minority Participants With Relapsing Multiple Sclerosis (RMS) After Initiation and During Treatment With Ocrelizumab.
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis, Relapsing
Interventions: DRUG: Ocrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SPEARHEAD-3 Pediatric Study
Status: RECRUITING
Conditions: Synovial Sarcoma|Malignant Peripheral Nerve Sheath Tumor (MPNST)|Neuroblastoma|Osteosarcoma
Interventions: GENETIC: Afamitresgene autoleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effect of Local Hypothermia in Treatment of Acute Myocardial Infarction
Status: UNKNOWN
Conditions: Acute Myocardial Infarction
Interventions: PROCEDURE: Infusion of Cold Saline into Local Infarction Myocardium.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Evaluate ABT-126 for the Treatment of Cognitive Deficits in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: ABT-126|DRUG: ABT-126|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive-behavioural Intervention for Anxiety, Depression and Quality of Life Among Children Receiving Chemotherapy.
Status: COMPLETED
Conditions: Hematologic Malignancy|Anxiety|Depression|Quality of Life
Interventions: OTHER: Cognitive-behavioural intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Combination Therapy for Prevention of Effects of Malaria During Pregnancy
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: sulfadoxine/pyrimethamine|DRUG: sulfadoxine/pyrimethamine plus artesunate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Fractionated Gemtuzumab Ozogamicin in Treating Measurable Residual Disease in Patients With Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Gemtuzumab Ozogamicin|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib Tosylate With or Without Pravastatin in Treating Patients With Liver Cancer and Cirrhosis
Status: COMPLETED
Conditions: Liver Cancer
Interventions: DRUG: pravastatin sodium|DRUG: sorafenib tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemoimmunotherapy in Recurrent Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: Pembrolizumab and Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension
Status: NOT_YET_RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction|Hypotension|LV Dysfunction
Interventions: DRUG: Midodrine Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Human Tolerance and Pharmacokinetics of LY03003
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: LY03003
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Response After Rituximab for Chronic, Severe Idiopathic Thrombocytopenic Purpura
Status: COMPLETED
Conditions: Idiopathic Thrombocytopenic Purpura|Immune Thrombocytopenic Purpura
Interventions: BIOLOGICAL: Inactivated Trivalent Influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Pharmacokinetics (PK) Drug Interaction Study of Milademetan and Itraconazole or Posaconazole in Healthy Participants
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Milademetan|DRUG: Itraconazole|DRUG: Posaconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Modulation of Intestinal and Pulmonary Inflammation by Lactobacillus Diet Supplementation in Pediatric Cystic Fibrosis
Status: UNKNOWN
Conditions: Pulmonary Inflammation|Cystic Fibrosis|Microbiota
Interventions: DIETARY_SUPPLEMENT: Lactobacillus rhamnosus|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cold Heart Study: A Randomized Pilot Trial of Surfactant Therapy
Status: TERMINATED
Conditions: Congenital Heart Disease|Hypoplastic Left Heart Syndrome
Interventions: DRUG: Curosurf|DRUG: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Telotristat With Lutathera in Neuroendocrine Tumors
Status: TERMINATED
Conditions: Neuroendocrine Tumors
Interventions: DRUG: Telotristat (Low-Dose)|DRUG: Telotristat (High-Dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Designing a Mixed-initiative Recipe Recommender App for Vegan and Vegetarian Sub-groups
Status: ENROLLING_BY_INVITATION
Conditions: Mobile Applications
Interventions: BEHAVIORAL: Recipes consumption|BEHAVIORAL: Hydroponic unit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessing the Efficacy of a Carbamide Peroxide Mouthwash for Oral Wound Healing, Oral Hygiene and Xerostomia Relief
Status: COMPLETED
Conditions: Wound Heal|Oral Dryness|Postoperative Pain|Sjogren's Syndrome|Biopsy Wound|Mouth; Wound|Mouth Dryness|Dental Plaque|Gingival Inflammation
Interventions: DEVICE: Carbamide Peroxide Mouthwash|DEVICE: Placebo mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Efficacy of Intravenous Ibuprofen in Biliary Colic
Status: COMPLETED
Conditions: Biliary Colic
Interventions: DRUG: IV Ibuprofen|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Generalized Anxiety Disorder Proof of Concept Efficacy and Safety Study of SEP-225441 (Eszopiclone) In GAD Subjects
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: DRUG: eszopiclone|DRUG: eszopiclone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Binge Eating & Birth Control
Status: TERMINATED
Conditions: Bulimia Nervosa|Binge Eating|Eating Disorders|Binge-Eating Disorder
Interventions: DRUG: Drospirenone-Ethinyl Estradiol Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Real Time In-Vivo Dosimetry For Gynecologic Brachytherapy
Status: COMPLETED
Conditions: Cancer of the Cervix, Cancer of the Endometrium
Interventions: DEVICE: Novel nano-scintillator fiber-optic dosimeter (nanoFOD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Integrated Diagnosis and Treatment of CKD on Outcomes
Status: RECRUITING
Conditions: Chronic Kidney Diseases|Hypertension|Hyperglycemia|Hyperlipidemias|Anemia|Chronic Kidney Disease-Mineral and Bone Disorder|Malnutrition
Interventions: OTHER: Integrated diagnosis and treatment for CKD
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparing Opioid Prescription Patterns in Total Joint Arthroplasty Patients
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: opioid pain pills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gastrointestinal Tolerance and Safety of an Infant Formula Containing Prebiotics, Probiotics and Postbiotics.
Status: COMPLETED
Conditions: Gastrointestinal Tolerance
Interventions: OTHER: Infant formula containing prebiotics, probiotics and postbiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Use of a Nerve Regeneration Conduit (NerVFIX®) in the Treatment of Nerve Section of the Wrist
Status: RECRUITING
Conditions: Nerve Injury|Nerve Lesion
Interventions: BIOLOGICAL: NerVFIX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tnf Inhibitors to Reduce Mortality in HIV-1 Infected PAtients With Tuberculosis meNIngitis
Status: RECRUITING
Conditions: Tuberculous Meningitis|HIV I Infection
Interventions: DRUG: Adalimumab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Customized Zirconia Sheet vs PTFE as a Non-resorbable Barrier in Maxillary Alveolar Ridge Augmentation
Status: RECRUITING
Conditions: Alveolar Bone Loss
Interventions: PROCEDURE: Maxillary alveolar ridge augmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Immunogenicity, Safety, and Tolerability of ZOSTAVAX™ Vaccine (Zoster Vaccine Live, V211) Administered Concomitantly Versus Nonconcomitantly With Quadrivalent Influenza Virus Vaccine (Inactivated) in Participants ≥50 Years of Age (V211-062)
Status: COMPLETED
Conditions: Herpes Zoster
Interventions: BIOLOGICAL: ZOSTAVAX™|BIOLOGICAL: Placebo to ZOSTAVAX™|BIOLOGICAL: Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: LUX-Head & Neck 4: Afatinib (BIBW 2992) Versus Placebo for the Treatment of Head and Neck Squamous Cell Cancer After Treatment With Chemo-radiotherapy
Status: TERMINATED
Conditions: Head and Neck Neoplasms
Interventions: DRUG: Placebo|DRUG: Afatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Dose Escalation Study of Selinexor Plus Nivolumab and Ipilimumab in Advanced/Metastatic Solid Malignancies
Status: RECRUITING
Conditions: Advance Solid Malignancies|Metastatic Solid Malignancies
Interventions: DRUG: Selinexor in combination with nivolumab and ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biliary Interventions in Critically Ill Patients With Secondary Sclerosing Cholangitis (BISCIT)
Status: TERMINATED
Conditions: Secondary Sclerosing Cholangitis
Interventions: PROCEDURE: Endoscopic retrograde cholangiography (ERC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venetoclax in Patients With MDS or AML in Relapse After AHSCT
Status: RECRUITING
Conditions: MDS|AML
Interventions: DRUG: venetoclax + azacitidine +/- donor lymphocyte infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: R-CHOP-14 Versus R-CHOP-21 and Darbepoetin Alpha in Patients Aged 60-80 Years With Diffuse Large B-cell Lymphoma
Status: COMPLETED
Conditions: Diffuse Large Cell Lymphoma
Interventions: DRUG: Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Progesterone vs Clobetasol Propionate in Vulvar Lichen Sclerosus
Status: TERMINATED
Conditions: Vulvar Lichen Sclerosus
Interventions: DRUG: Clobetasol propionate 0.05%|DRUG: Progesterone 8%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Mindfulness Based Cognitive Group Therapy for Social Anxiety Symptoms in People Living With Alopecia Areata
Status: COMPLETED
Conditions: Alopecia Areata|Social Anxiety
Interventions: BEHAVIORAL: Mindfulness Based Cognitive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT