pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Multisite RCT of STEP-Home: A Transdiagnostic Skill-based Community Reintegration Workshop
Status: COMPLETED
Conditions: Post-traumatic Stress Disorder|Traumatic Brain Injury|Substance Related Disorders|Depression|Anxiety Disorders|Suicide|Pain
Interventions: BEHAVIORAL: STEP-Home|BEHAVIORAL: PCGT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cyclophosphamide, Methotrexate, and Fluorouracil, With or Without Epirubicin Hydrochloride, in Treating Women Who Have Undergone Surgery for Breast Cancer (Group III Closed to New Patients as of 12/7/2009)
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: epirubicin hydrochloride|DRUG: fluorouracil|DRUG: methotrexate|OTHER: laboratory biomarker analysis|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Scorpio NRG (eNeRGize) Cruciate Retaining (CR) Post-market International Outcome Study
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Knee
Interventions: DEVICE: Primary total knee replacement (Scorpio NRG CR Total Knee System)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Ribociclib in Pre- and Postmenopausal Chinese Women With HR Positive, HER2-negative, Advanced Breast Cancer.
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Ribociclib Placebo|DRUG: Ribociclib|DRUG: NSAI: Letrozole or Anastrazole|DRUG: Letrozole|DRUG: Goserelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Levofloxacin Ocular Implant in Patients Undergoing Routine Bilateral Cataract Surgery
Status: WITHDRAWN
Conditions: Cataract
Interventions: DRUG: Levofloxacin Ocular Implant|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Sedation in COVID-19-related Acute Respiratory Distress Syndrome (ISCA): an International Research Data Study in the Recent Context of Widespread Disease Resulting From the 2019 (SARS-CoV2) Coronavirus Pandemics (COVID-19)
Status: COMPLETED
Conditions: Critically Illness|Sedation|Invasive Mechanical Ventilation|Acute Respiratory Distress Syndrome
Interventions: DRUG: Intravenous sedation|DRUG: Inhaled sedation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Is There a Difference in Flicker Induced Vasodilatation Between Smokers and Non-Smokers?
Status: COMPLETED
Conditions: Ocular Physiology|Retina|Blood Flow Velocity
Interventions: PROCEDURE: flicker light stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Comparison of Dynamic and Static Medial Patellofemoral Ligament Operation Technique for Recurrent Patellar Dislocation
Status: RECRUITING
Conditions: Patellar Instability
Interventions: PROCEDURE: Static reconstruction technique according to Schöttle|PROCEDURE: Dynamic reconstruction technique according to Becher
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 129Xe MRI Cardiopulmonary
Status: RECRUITING
Conditions: Interstitial Lung Disease|Chronic Thromboembolic Pulmonary Hypertension|Acute Pulmonary Embolism|Anemia|Polycythemia|Dyspnea
Interventions: DRUG: Hyperpolarized Xe129|OTHER: Oxygen Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Increasing Activity Post-Kidney Transplant With SystemCHANGE
Status: COMPLETED
Conditions: Kidney Transplant; Complications|Physical Activity|Cardiorenal; Change|Cardiovascular Diseases
Interventions: BEHAVIORAL: Fitbit (Control)|BEHAVIORAL: SystemCHANGE and Fitbit (Intervention)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nepafenac 0.1% Eye Drops, Suspension Compared to Ketorolac Trometamol 0.5% Eye Drops, Solution and Placebo
Status: COMPLETED
Conditions: Cataracts
Interventions: DRUG: Nepafenac 1mg/ml eye drops, suspension|DRUG: Ketorolac Trometamol 5 mg/ml eye drops, solution|OTHER: Nepafenac vehicle eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sapanisertib in Treating Patients With Relapsed and/or Refractory Acute Lymphoblastic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: B Acute Lymphoblastic Leukemia|B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative|Recurrent Adult Acute Lymphoblastic Leukemia|Refractory Adult Acute Lymphoblastic Leukemia|T Acute Lymphoblastic Leukemia
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Sapanisertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trigeminal Nerve Stimulation for Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention-Deficit/Hyperactivity Disorder
Interventions: DEVICE: EMS 7500 Digital Muscle Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dry Needling Versus Intramuscular Stimulation in the Management of the Myofascial Trigger Points
Status: COMPLETED
Conditions: Trigger Point Pain, Myofascial|Muscle Pain|Myofascial Pain Syndrome
Interventions: OTHER: Dry needling and electric stimulation|OTHER: Dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study to Assess Safety and Efficacy of Mylan's Insulin Glargine and Lantus® in Type 1 Diabetes Mellitus (T1DM) Patients
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Mylan's insulin glargine|DRUG: Lantus®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Osteoarthritis|Pain Management
Interventions: DRUG: bupivacaine liposome injectable suspension|DRUG: Bupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM)
Status: COMPLETED
Conditions: Pancreatic Cancer|Pancreas Cancer|Pancreatic Adenocarcinoma Resectable|Pancreatic Ductal Adenocarcinoma|Pancreas Metastases
Interventions: DRUG: Ascorbic Acid|DRUG: Paclitaxel protein-bound|DRUG: Cisplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Text Messaging in Healthcare Utilization
Status: COMPLETED
Conditions: Text Messaging
Interventions: BEHAVIORAL: Enhanced Standard of Care (ESoC) + Text|BEHAVIORAL: Enhanced Standard of Care (ESoC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Constitution of ex Vivo Ovarian Tumor Models for the Validation of the Interest of Innovative Therapies and the Search for Tumor or Circulating Biomarkers Predictive of Treatment Response
Status: RECRUITING
Conditions: Ovarian Cancer
Interventions: GENETIC: collection of blood, urine, tumor and ascite samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ibrutinib for Patients With Follicular Lymphoma Without Complete Response to Initial Chemoimmunotherapy
Status: TERMINATED
Conditions: Follicular Lymphoma|Follicular Lymphoma, Grade 1|Follicular Lymphoma, Grade 2|Follicular Lymphoma Grade IIIa
Interventions: DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab w / Temozolomide PET & Vascular MRI For GBM
Status: COMPLETED
Conditions: Recurrent Glioblastoma
Interventions: DEVICE: MRI-PET|DEVICE: TMZ-PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparsion of King Vision® Standard Blade and King Vision® Channeled Blade in Patients Scheduled for Tracheal Intubation
Status: COMPLETED
Conditions: Hypoxemia
Interventions: DEVICE: channeled blade|DEVICE: standard blade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Response of Shingrix Vaccine in People Living With HIV (> 50 y.o.) Compared to Age-matched Controls
Status: RECRUITING
Conditions: RZV Vaccine (Shingrix ®)
Interventions: BIOLOGICAL: Recombinant Zoster Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Brimonidine Tartrate/Ketotifen Fumarate Combination for the Treatment of Allergic Conjunctivitis
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: Brimonidine tartrate 0.025% / ketotifen fumarate 0.035% combo|DRUG: Ketotifen fumarate ophthalmic solution 0.035%|DRUG: Brimonidine tartrate ophthalmic solution 0.025%|DRUG: Vehicle ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Influence of Different Skin Conditions on the Allergic Skin Reactivity to Epicutanous Allergen Exposure
Status: COMPLETED
Conditions: Birch Pollen Allergy
Interventions: DEVICE: Microporation by P.L.E.A.S.E. Professional / Prick needle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect Of Occlusal Materials Used For All On Four Mandibular Implant Prosthesis With PEEK Framework
Status: COMPLETED
Conditions: Occlusal Trauma
Interventions: PROCEDURE: dental implants|PROCEDURE: peek framework|PROCEDURE: visio-lign nano composite|PROCEDURE: zirconia crowns
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study for VeinoPlus to Improve Symptoms of Postthrombotic Syndrome (PTS)
Status: COMPLETED
Conditions: Post Thrombotic Syndrome|Deep Vein Thrombosis|Venous Stasis Syndrome|Venous Insufficiency|Postphlebitic Syndrome
Interventions: DEVICE: VeinOPlus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi_center Study to Evaluate the Effect of N-3 Fatty Acids (OMEGA-3) on Arrhythmia Recurrence in Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: OMEGA-3|DRUG: Placebo soybean oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outcomes in the Palm of Your Hand: Improving the Quality and Continuity of Patient Care
Status: UNKNOWN
Conditions: Computers, Handheld|Outcomes Assessment, Patient
Interventions: DEVICE: handheld Personal Digital Assistant (PDA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Oral Chinese Herbal Medicine for Psoriasis Vulgaris With Blood Heat Syndrome
Status: UNKNOWN
Conditions: Psoriasis Vulgaris
Interventions: DRUG: Jueyin granules|DRUG: Jueyin Granules Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of LY2495655 in Participants With Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: LY2495655|DRUG: Placebo|DRUG: Standard of Care Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing an Oral Janus Kinase Inhibitor, AZD4205, in Combination With Osimertinib in Patients Who Have Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Nonsmall Cell Lung Cancer
Interventions: DRUG: AZD4205
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Cervical Screening in HPV Vaccinated Women
Status: UNKNOWN
Conditions: Cervical Intraepithelial Neoplasia Grade 2/3
Interventions: OTHER: Cytological screening in A1 and A3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Clinical Evaluation of Silver Nanoparticles in Comparison to Silver Diamine Fluoride in Management of Deep Carious Lesions
Status: COMPLETED
Conditions: Caries,Dental
Interventions: DRUG: silvernanoparticles|DRUG: SDF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and the Efficacy of EscharEx (EX-02 Formulation) in Debridement of Venous Leg Ulcers
Status: COMPLETED
Conditions: Venous Leg Ulcer
Interventions: DRUG: EscharEx (5% EX-02 formulation)|DRUG: Gel Vehicle|DRUG: Non-surgical standard of care (NSSOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Placebo Controlled Study Of The Efficacy And Safety Of PF-02545920 In Subjects With Huntington's Disease
Status: COMPLETED
Conditions: Huntington's Disease
Interventions: DRUG: PF-02545920|DRUG: PF-02545920|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics (PK)/ Pharmacodynamics (PD) of an Extended Wear Infusion Set for Continuous Subcutaneous Insulin Infusion (CSII) in Type 1 Diabetes Mellitus (T1DM) Patients ("PEXIS")
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Type 1 Diabetes
Interventions: DEVICE: coil-reinforced soft polymer indwelling cannula|DEVICE: soft Teflon indwelling catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: TRUST-ACE - Anticancer-treatment Cardiotoxicity Identification by Echocardiography
Status: RECRUITING
Conditions: Breast Neoplasm Malignant Primary
Interventions: DIAGNOSTIC_TEST: Comprehensive echocardiographic follow-up|DIAGNOSTIC_TEST: Simplified echocardiographic follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Efficacy and Safety of DBPR108 100 mg in Type 2 Diabetes Mellitus Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: DBPR108; Placebo matching sitagliptin|DRUG: Placebo matching DBPR108; Sitagliptin; DBPR108|DRUG: Placebo matching DBPR108; Placebo matching sitagliptin; DBPR108
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of GV20-0251 in Patients With Solid Tumor Malignancies
Status: RECRUITING
Conditions: Solid Tumor, Adult|Refractory Cancer|Bladder Urothelial Carcinoma|Cholangiocarcinoma|Adenocarcinoma of the Colon|Endometrial Carcinoma|Head and Neck Carcinoma|Cutaneous Melanoma|Non-small Cell Lung Cancer|Adenocarcinoma of the Rectum
Interventions: DRUG: GV20-0251|DRUG: GV20-0251
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ambulatory Versus Inpatient Initiation of Home Mechanical Ventilation
Status: RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: OTHER: Outpatient|OTHER: Hospitalization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating ERB-041 With Methotrexate in Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Methotrexate plus ERB-041 for 12 weeks|DRUG: Placebo for 12 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Individual and Group Exercise Program for Industrial Workers With CANS: Randomized Controlled Trial
Status: UNKNOWN
Conditions: Musculoskeletal Disorder of the Neck
Interventions: OTHER: Group Exercise Program|OTHER: Individual Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Treatment of Durvalumab, Bevacizumab, Tremelimumab and Transarterial Chemoembolization (TACE) in Subjects With Hepatocellular Carcinoma or Biliary Tract Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Cancer|Hepatocellular Carcinoma|Metastatic Hepatocellular Carcinoma
Interventions: DRUG: durvalumab|DRUG: Doxorubicin-Eluting Beads|PROCEDURE: TACE|DRUG: bevacizumab|DRUG: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MDCT vs. CBCT Guided Percutaneous Lung Nodule Biopsy: A Comparison of Pneumothorax Incidence and Associated Risk Factors
Status: RECRUITING
Conditions: Lung Diseases
Interventions: PROCEDURE: cone beam computed tomography (CBCT) for percutaneous transthoracic needle biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: ASP 8825 - Study in Patients With Painful Diabetic Polyneuropathy
Status: TERMINATED
Conditions: Diabetic Neuropathies
Interventions: DRUG: ASP8825|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: National Multicenter Trial Evaluating Two Treatments in Patients With Primary Human Immunodeficiency Virus (HIV-1) Infection
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: Dolutegravir|DRUG: Darunavir-cobicistat|DRUG: Emtricitabine-Tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Ultrasound-guided Corticosteroid Injection Versus Corticosteroid Injection and Hydrodissection for Carpal Tunnel Syndrome
Status: UNKNOWN
Conditions: Carpal Tunnel Syndrome
Interventions: DRUG: Triamcinolone Acetonide|DRUG: lidocaine hydrochloride|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Biomedical Investigations for Optimized Diagnosis and Monitoring of Severe Acute Malnutrition (SAM): Elucidating the Heterogeneous Diagnosis of SAM by Current Anthropometric Criteria and Moving Beyond
Status: COMPLETED
Conditions: Severe Acute Malnutrition
Interventions: OTHER: Severe Acute Malnutrition
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Endocrine Therapy Fulvestrant & Palbociclib or Aromatase Inhibitor Therapy in Treating Older Patients With Hormone Responsive Breast Cancer That Cannot Be Removed by Surgery
Status: RECRUITING
Conditions: Estrogen Receptor and/or Progesterone Receptor Positive|HER2/Neu Negative|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: DRUG: Fulvestrant|OTHER: Laboratory Biomarker Analysis|DRUG: Palbociclib|OTHER: Questionnaire Administration|DRUG: Aromatase Inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PrEP and Alcohol - Enhancing HIV Pre-Exposure Prophylaxis (PrEP)
Status: ACTIVE_NOT_RECRUITING
Conditions: Hazardous Alcohol Use
Interventions: BEHAVIORAL: Alcohol-focused brief intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Safety and Effectiveness Study of TMC435 in Chronic, Genotype 1, Hepatitis C Patients Who Failed to Previous Standard Treatment
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: TMC435|DRUG: Placebo|DRUG: Peg-IFN-alfa-2a (P)|DRUG: Ribavirin (R)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Can Antioxidants Affect Pregnancy Rate in Patients With Expected Low Number of Egg Retrieval in IVF Cycles?
Status: COMPLETED
Conditions: Infertility, Female
Interventions: DRUG: Antioxidant Formula|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study: PET Imaging of Cancer Patients Using [18F] 4-L-Fluoroglutamine (2S,4R)
Status: RECRUITING
Conditions: Solid Malignancy|Lymphoma
Interventions: DRUG: [18F] 4-L-Fluoroglutamine (2S,4R)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Efficacy of Topical Flutamide in the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris Superficial Mixed Comedonal and Inflammatory
Interventions: DRUG: Flutamide 1% gel|DRUG: topical gel without flutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment II-2 - 5
Status: WITHDRAWN
Conditions: Heroin Dependence|Opioid-Related Disorders
Interventions: DRUG: Opioid-Related Disorders
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Efficacy for CGF166 in Patients With Unilateral or Bilateral Severe-to-profound Hearing Loss
Status: COMPLETED
Conditions: Unilateral Severe to Profound Hearing Loss OR Bilateral Severe to Profound Hearing Loss
Interventions: DRUG: CGF166
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SMaRT Mom - Smartphone Management and Responsive Time for Breastfeeding Mothers
Status: RECRUITING
Conditions: Smartphone Addiction|Breastfeeding|Infant Behavior|Mother-Infant Interaction
Interventions: BEHAVIORAL: SMaRT Mom
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: TRAIN Your Sleep; Treating Adolescent Insomnia With Cognitive Behavioral Therapy for Insomnia (CBT-I)
Status: TERMINATED
Conditions: Insomnia|Chronic Pain
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy - Insomnia (CBT-I)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Oral Vinorelbine Plus Capecitabine Versus Taxane-gemcitabine Combinations as 1st Line Chemotherapy in Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: oral vinorelbine|DRUG: Capecitabine|DRUG: Gemcitabine 1250 mg/m²|DRUG: Gemcitabine 1000 mg/m²|DRUG: Paclitaxel|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cabozantinib Combined With PD-1 and CTLA-4 Inhibition in Metastatic Soft Tissue Sarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Soft-tissue Sarcoma
Interventions: DRUG: Cabozantinib|DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams
Status: UNKNOWN
Conditions: Respiratory Distress Syndrome
Interventions: DRUG: Surfactant|DEVICE: Nasal CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of 14:10 Time-Restricted Eating on Body Weight and Metabolic Markers
Status: COMPLETED
Conditions: Time Restricted Feeding
Interventions: BEHAVIORAL: 14:10 Regimen|BEHAVIORAL: 12:12 Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate The Relationship Between Plasma Drug Levels And Receptor Binding in Lung Using PET (Positron Emission Tomography) In Healthy Volunteers
Status: COMPLETED
Conditions: Immunology
Interventions: DRUG: BMS-986020|DRUG: [11C]BMT-136088
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Effectiveness Evaluation of TEOSYAL® TPVM Versus COMPARATOR for the Remodeling of the Lower Face
Status: RECRUITING
Conditions: Aging|Chin Retrusion
Interventions: DEVICE: TEOSYAL® TPVM|DEVICE: COMPARATOR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: a Study Conducted About a New Mode of Ventilation in Laparoscopic Surgeries
Status: UNKNOWN
Conditions: Lung Injury, Acute
Interventions: OTHER: inverse ratio ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of U3-1402 (Patritumab Deruxtecan) in Subjects With Metastatic Breast Cancer
Status: RECRUITING
Conditions: Metastatic Breast Cancer|Locally Advanced Breast Cancer
Interventions: DRUG: U3-1402
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COmparison and Modification in Neointimal Pattern Assessed by Optical Coherence Tomography With High Versus Moderate Efficacy Statin Treatment After Drug Eluting Stent Implantation: COMPASS Trial
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Atorvastatin 40mg|DRUG: pravastatin 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Dose Japanese Bridging Study
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: BMS-708163|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Influence of Dietary Nitrate on Skin Inflammation
Status: COMPLETED
Conditions: Cardiovascular Diseases|Inflammation|Inflammation; Skin|Inflammatory Response|Nitric Oxide
Interventions: DIETARY_SUPPLEMENT: Nitrate-rich Beetroot Juice|DIETARY_SUPPLEMENT: Nitrate-deplete Beetroot Juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparative Study of Ultrasound-guided Paravertebral Block Versus Intravenous Tramadol in Percutaneous Nephrolithotomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Ultrasound-guided Paravertebral Block|DRUG: Group Tramadol|DRUG: Bupivacaine|DEVICE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fluoxetine Versus Fluoxetine Plus DU125530 in Major Depressive Disorder
Status: TERMINATED
Conditions: Major Depression
Interventions: DRUG: DU125530|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Infrared Coagulation in Preventing Anal Cancer in Patients With HIV Who Have Anal Neoplasia
Status: COMPLETED
Conditions: Anal Cancer|Precancerous Condition
Interventions: PROCEDURE: infrared photocoagulation therapy|DEVICE: Infrared Coagulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Nighttime Access to Care and Treatment; Part 4-Haiti
Status: RECRUITING
Conditions: Telemedicine|Pediatrics
Interventions: OTHER: paper-based clinical decision support (dCDS) tool|OTHER: digital clinical decision support (dCDS) tool
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: DUAL Antithrombotic Therapy in Patients With AF and ACS
Status: UNKNOWN
Conditions: Atrial Fibrillation|Acute Coronary Syndromes
Interventions: DRUG: Rivaroxaban 15 MG Oral Tablet|DRUG: Clopidogrel 75 Mg Oral Tablet|DRUG: Ticagrelor 90 MG Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Lisdexamfetamine Dimesylate With Atomoxetine HCl in Attention-Deficit/Hyperactivity Disorder (ADHD) Subjects With an Inadequate Response to Methylphenidate
Status: COMPLETED
Conditions: Attention-Deficit/Hyperactivity Disorder
Interventions: DRUG: Lisdexamfetamine Dimesylate|DRUG: Atomoxetine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Pediatric Participants (MK-0869-208)
Status: COMPLETED
Conditions: Chemotherapy Induced Nausea and Vomiting
Interventions: DRUG: Aprepitant 125 mg|DRUG: Aprepitant 80 mg|DRUG: Aprepitant powder for suspension (PFS)|DRUG: Ondansetron|DRUG: Placebo for Aprepitant 125 mg|DRUG: Placebo for Aprepitant 80 mg|DRUG: Placebo for Aprepitant PFS|DRUG: Emetogenic chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Conectar Jugando: Board Games in Rural Elementary Classrooms (6-12 Years Old) to Improve Executive Functions
Status: COMPLETED
Conditions: Cognitive Change|Child Development
Interventions: BEHAVIORAL: Conectar Jugando Game Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Maintenance Treatment With BGB-290 Versus Placebo in Participants With Platinum-sensitive Recurrent Ovarian Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: Pamiparib capsule|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of (Buspar) Buspirone HCl Tablets Under Fasting and Fed Conditions
Status: COMPLETED
Conditions: To Determine Bioequivalence Under Fed Conditions
Interventions: DRUG: Buspirone HCl|DRUG: Buspirone HCl|DRUG: Buspar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Study on the Efficiency of Three Different Attachment Systems for Implant-supported Mandibular Overdenture
Status: COMPLETED
Conditions: MANDIBLE|ATROPHYC EDENTULOUS JAW
Interventions: PROCEDURE: Insertion of dental implants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Treatment BI 1744 CL (5 and 10 mcg) Versus Placebo on Exercise Endurance Time During Constant Work Rate Cycle Ergometry I
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Olodaterol (BI 1744)|DRUG: Olodaterol (BI 1744)|DRUG: Placebo|DRUG: Olodaterol (BI 1744)|DRUG: Olodaterol (BI 1744) Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Virtual Reality Application on Anxiety and Patient Satisfaction During Intrauterine Insemination (IUI)
Status: NOT_YET_RECRUITING
Conditions: Virtual Reality|Anxiety|Patient Satisfaction|Intrauterine Insemination (IUI)
Interventions: DEVICE: Virtual reality glasses to intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Iron Supplementation on Right Ventricular Function and Exercise Performance in Hypoxia
Status: NOT_YET_RECRUITING
Conditions: Right Ventricular Dysfunction|Hypoxia
Interventions: DRUG: Ferrous sulfate 325mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: COVID-19 Booster Readiness Survey
Status: COMPLETED
Conditions: Vaccination Refusal
Interventions: BEHAVIORAL: Salience of Omicron variant|BEHAVIORAL: Self-protection message|BEHAVIORAL: Other-protection message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), Food-effect of TRK-750
Status: COMPLETED
Conditions: Healthy, Peripheral Neuropathic Pain
Interventions: DRUG: TRK-750|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Foot Massage on Pain, Sleep Quality and Early Discharge in Patients Undergoing Spinal Surgery
Status: COMPLETED
Conditions: Spinal Fusion|Pain, Postoperative
Interventions: OTHER: Foot Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pressure Assessment to Improve Outcomes After TAVR: a Registry
Status: COMPLETED
Conditions: Hypertension|Aortic Stenosis, Calcific|Quality of Life|Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: Eplerenone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adding Male Single Dose HPV Vaccination to Female HPV Vaccination in Tanzania
Status: ACTIVE_NOT_RECRUITING
Conditions: HPV Infection|Vaccine Preventable Disease
Interventions: BIOLOGICAL: Gardasil® HPV vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Evaluation of Exenatide and Rosiglitazone in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: exenatide|DRUG: rosiglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exemestane or Docetaxel-Cytoxan in Low Recurrence Score Cancers
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Exemestane|DRUG: Docetaxel|DRUG: Cytoxan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Ascending Single-Dose Of Bosutinib Administered With Multiple Doses Of Ketoconazole To Healthy Subjects
Status: COMPLETED
Conditions: Breast Cancer|Tumors|Leukemia
Interventions: DRUG: Bosutinib (SKI-606)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Penicillamine Chelation for Children With Lead Poisoning
Status: WITHDRAWN
Conditions: Lead Poisoning|Vitamin D Deficiency
Interventions: DEVICE: d-penicillamine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fibrinolytic Therapy to Treat ARDS in the Setting of COVID-19 Infection
Status: COMPLETED
Conditions: Severe Acute Respiratory Syndrome|Respiratory Failure|Acute Respiratory Distress Syndrome
Interventions: DRUG: Alteplase 50 MG [Activase]|DRUG: Alteplase 50 MG [Activase]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sedation Of Adult Patients Undergoing Gastrointestinal Endoscopy: A Network Meta-analysis
Status: COMPLETED
Conditions: Gastrointestinal Endoscopy|Sedation|Dexmedetomidine
Interventions: DRUG: Dexmedetomidine|DRUG: Midazolam|DRUG: Propofol|DRUG: Midazolam/Propofol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Efficacy of Cone Beam Computed Tomography (CBCT) Compared to Panoramic Radiography Prior to Third Molar Removal
Status: COMPLETED
Conditions: Inferior Alveolar Nerve Injury
Interventions: PROCEDURE: Third molar removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Intravenous Neridronic Acid in CRPS-I
Status: COMPLETED
Conditions: Complex Regional Pain Syndrome, Type I
Interventions: DRUG: Placebo|DRUG: Neridronic acid 62.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Acupuncture Treatment Effect Through Non-invasive Neuromodulation
Status: RECRUITING
Conditions: Chronic Pain
Interventions: DEVICE: verum acupuncture|DEVICE: sham acupuncture|DEVICE: real tDCS|DEVICE: sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Two Topical K40 Formulations in Adults With Seborrhoeic Dermatitis (SD) of the Scalp
Status: COMPLETED
Conditions: Seborrhoeic Dermatitis of the Scalp
Interventions: DRUG: K40a|DRUG: K40b|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Budesonide Foam Versus Placebo for Prevention of Acute Radiation Proctitis
Status: TERMINATED
Conditions: Radiation Proctitis
Interventions: DRUG: budesonide|DRUG: Placebo foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nocturnal Continuous Positive Airway Pressure in Chronic Obstructive Pulmonary Disease Patients
Status: WITHDRAWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: continuous positive airway pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Busulfan, Etoposide, and Total-Body Irradiation in Treating Patients Undergoing Donor Stem Cell or Bone Marrow Transplant for Advanced Hematologic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: busulfan|DRUG: cyclosporine|DRUG: etoposide|DRUG: mycophenolate mofetil|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: total-body irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Oropharyngeal Exercises for Patients With Obstructive Sleep Apnea Using Mandibular Advancement Device
Status: RECRUITING
Conditions: Obstructive Sleep Apnea of Adult
Interventions: OTHER: Oropharyngeal Exercises|OTHER: Mandibular advancement device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Mindfulness Training on Emotion Regulation and Impulsivity
Status: COMPLETED
Conditions: Mindfulness Skills|Interpersonal Effectiveness Skills
Interventions: BEHAVIORAL: Mindfulness skills training|BEHAVIORAL: Interpersonal Effectiveness skills training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Active Surveillance and Chemotherapy Before Surgery in Treating Participants With Stage II-III Rectal Cancer
Status: RECRUITING
Conditions: Rectal Adenocarcinoma|Stage II Rectal Cancer AJCC v8|Stage IIA Rectal Cancer AJCC v8|Stage IIB Rectal Cancer AJCC v8|Stage IIC Rectal Cancer AJCC v8|Stage III Rectal Cancer AJCC v8|Stage IIIA Rectal Cancer AJCC v8|Stage IIIB Rectal Cancer AJCC v8|Stage IIIC Rectal Cancer AJCC v8
Interventions: DRUG: Chemotherapy|OTHER: Patient Observation|OTHER: Questionnaire Administration|PROCEDURE: Resection of Rectum
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Two-part Trial Assessing the Effects of 7α-methyl-19-nortestosterone (MENT) on Blood Pressure in Normal Men: an Open-label Pilot Study Followed by a Randomized, Double-blind, Placebo-controlled Study
Status: COMPLETED
Conditions: Blood Pressure
Interventions: DRUG: MENT or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Feasibility, Reliability, and Satisfaction of CEA Using Home Based (Automated) Capillary Blood Sampling
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DIAGNOSTIC_TEST: TAP-II|DIAGNOSTIC_TEST: Lancet capillary sampling|DIAGNOSTIC_TEST: Venipuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Sitagliptin Comparative Study in Patients With Type 2 Diabetes (0431-049)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: sitagliptin phosphate|DRUG: Comparator: metformin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-restorative Cavity Control in Anterior Cavitated Caries Lesion of Primary Teeth
Status: SUSPENDED
Conditions: Dental Caries
Interventions: PROCEDURE: Non-restorative cavity control - NRCC group|PROCEDURE: Restoration with resin composite - RCR group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Localized Piezoelectric Alveolar Decortication With Customized Orthodontic Treatment in Adults
Status: COMPLETED
Conditions: Tooth Overcrowding
Interventions: PROCEDURE: Orthodontic Procedure|PROCEDURE: Piezocision surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Long-term Safety of Tafamidis in Subjects With Transthyretin Cardiomyopathy
Status: COMPLETED
Conditions: Transthyretin (TTR) Amyloid Cardiomyopathy
Interventions: DRUG: Tafamidis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of CU104 in Moderate-Severe Ulcerative Colitis
Status: NOT_YET_RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: CU104|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fenfluramine for the Treatment of Different Types of Developmental and Epileptic Encephalopathies: a Pilot Trial Exploring Epileptic and Non-epileptic Outcomes
Status: RECRUITING
Conditions: Refractory Epilepsy|SYNGAP1 Encephalopathy|STXBP1 Encephalopathy With Epilepsy|Inv Dup(15) Encephalopathy|Multifocal or Bilateral Malformations of Cortical Development|Continuous Spike and Waves During Slow Sleep
Interventions: DRUG: Fenfluramine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating The PK And Safety Of Neratinib In Healthy Subjects And Subjects With Chronic Liver Disease
Status: COMPLETED
Conditions: Hepatic Insufficiency
Interventions: DRUG: Neratinib (HKI-272)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: