pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A PK Comparability Study of Two Different Amlitelimab Drug Products in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Amlitelimab DP1|DRUG: Amlitelimab DP2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Mechanical Properties and Clinical Efficacy of Two Nickel-Titanium (NiTi) Archwires
Status: UNKNOWN
Conditions: Crowding of Anterior Mandibular Teeth
Interventions: DEVICE: .014" NiTi heat-activated archwire|DEVICE: .014" NiTi Superelastic archwire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Complementary Neurosteroid Intervention in Gulf War Illnesses (GWVI)
Status: COMPLETED
Conditions: Fatigue|Musculoskeletal Pain|Cognitive Decline
Interventions: DRUG: Pregnenolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effect of Chewing Sticks and Toothbrushing on Plaque Removal and Gingival Health
Status: COMPLETED
Conditions: Plaque Induced Gingivitis
Interventions: PROCEDURE: Salvadora persica|PROCEDURE: Toothbrush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SUSTAIN SWITCH: A Research Study to Compare Two Dose Schedules of Semaglutide Taken Once Weekly in People With Type 2 Diabetes
Status: WITHDRAWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HPV-based Screening Among Women 23-29 Years of Age
Status: RECRUITING
Conditions: Human Papilloma Virus|Cervical Intraepithelial Neoplasia|Cervical Cancer
Interventions: DIAGNOSTIC_TEST: HPV testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant of Tislelizumab Combined With Chemotherapy Followed by Surgery in Unresectable Stage Ⅲ NSCLC
Status: RECRUITING
Conditions: NSCLC, Stage III
Interventions: DRUG: Tislelizumab|DRUG: Pemetrexed (Nonsquamous NSCLC) or Paclitaxel/Nab-paclitaxel(Squamous NSCLC)|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Cardiac Safety of TAS-102 in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors (Excluding Breast Cancer)
Interventions: DRUG: TAS-102|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Primary or Recurrent Clostridioides Difficile Infection Treatment With Capsules of Lyophilised Faecal Microbiota vs Fidaxomicin
Status: COMPLETED
Conditions: Recurrent Clostridium Difficile Infection|Primary Clostridium Difficile Infection
Interventions: BIOLOGICAL: MBK-01|DRUG: Dificlir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Immediately Placed Dental Implants With Local Application of Injectable PRF in Periodontally Compromised Sites
Status: COMPLETED
Conditions: Bone Density|Bone Loss, Alveolar
Interventions: BIOLOGICAL: I-PRF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Center of Research Translation (CORT) Project 2
Status: COMPLETED
Conditions: Pre-hypertension|JNC 7 Stage I Hypertension
Interventions: DRUG: Allopurinol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study of Paliperidone Palmitate and Risperidone Long Acting Injection (LAI) in Participants With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Paliperidone palmitate (R092670)|DRUG: Risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of High Dose Methylprednisolone on Nailfold in Early Systemic Sclerosis ( SSc )
Status: UNKNOWN
Conditions: Systemic Sclerosis|Raynaud Phenomena
Interventions: DRUG: Methylprednisolone|OTHER: sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neuropilates Compared to General Exercise Classes in Chronic Stroke
Status: UNKNOWN
Conditions: Stroke
Interventions: PROCEDURE: Home 'General' exercise instructions.|PROCEDURE: Home 'Neuropilates' exercise instructions.|PROCEDURE: Supervised Neuropilates Group Class|PROCEDURE: Supervised General Exercises Group Class
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colonisation of Scalp by Topical Probiotic Micrococcus Luteus Q24
Status: NOT_YET_RECRUITING
Conditions: Microbial Colonization
Interventions: OTHER: Active Comparator: Study Group A: Blis Q24 Serum at higher dose|OTHER: Active Comparator: Study Group B: Blis Q24 Serum at lower dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and PK/PD of TG-0054 in Multiple Myeloma, Non-Hodgkin Lymphoma and Hodgkin Disease Patients
Status: COMPLETED
Conditions: Multiple Myeloma|Non-Hodgkin Lymphoma|Hodgkin Disease
Interventions: DRUG: TG-0054 (2.24 mg/kg)|DRUG: TG-0054 (3.14 mg/kg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Sitagliptin Withdrawal Study (MK-0431-845)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin|DRUG: Placebo to sitagliptin|DRUG: Metformin|DRUG: Metformin XR|DRUG: Insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Irreversible Electroporation(IRE) For Unresectable Renal Pelvic and Ureteral Neoplasms
Status: COMPLETED
Conditions: Renal Pelvic and Ureteral Neoplasms
Interventions: PROCEDURE: rreversible electroporation (IRE)|DEVICE: NanoKnife
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Different Initial Insulin Dose Regimens on Time to Achieve Glycemic Targets and Treatment Safety in SIIT
Status: UNKNOWN
Conditions: Diabetes Mellitus|Diabetes Mellitus, Type 2|Glucose Metabolism Disorders|Metabolic Disease|Endocrine System Diseases
Interventions: DRUG: CSII with formula-based initial insulin regimen|DRUG: CSII with weight-based initial insulin regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Peginterferon Alfa-2a (Pegasys) When Administered in Combination With Ribavirin in Patients With Chronic Hepatitis C (CHC)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Peginterferon alfa-2a|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pivotal Study To Evaluate The Effectiveness of Isometric Handgrip Therapy In Prehypertensive And Hypertensive Patients
Status: TERMINATED
Conditions: Hypertension, Systolic
Interventions: DEVICE: Zona Plus Device|DEVICE: Control Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Offering Influenza and Pneumococcal Vaccine to Patients Being Evaluated in the Emergency Department
Status: UNKNOWN
Conditions: High Risk for Serious Influenza|High Risk for Pneumonia
Interventions: BIOLOGICAL: Influenza vaccination|BIOLOGICAL: Pneumococcal polysaccharide vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Objectives of This Study Are Study of the Reactogenicity, Safety and Immunogenicity of Flu-M Inactivated Split Influenza Vaccine in Volunteers Aged 18-60 Years
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Inactivated Split Influenza Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Is Endotracheal Tube Use Mandatory in Patients Undergoing Nasal Septum Surgery?
Status: COMPLETED
Conditions: Airway Aspiration|Airway Complication of Anesthesia
Interventions: DEVICE: Laryngeal mask airway|DEVICE: Endotracheal tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Study to Evaluate the Tolerability, Safety and Efficacy of Enteric-coated Mycophenolate Sodium After Equimolar Conversion From Mycophenolate Mofetil (MMF) in Patients With Renal Transplant
Status: COMPLETED
Conditions: Prevention of Acute Rejection After Kidney Transplantation
Interventions: DRUG: Enteric-Coated Mycophenolate Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Exploratory Clinical Study of CD19 CAR NK Cell Injection for the Treatment of Relapsed/Refractory Autoimmune Diseases
Status: RECRUITING
Conditions: Autoimmune Diseases
Interventions: DRUG: CD19 CAR NK cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Cultured Allogeneic Adult Umbilical Cord Stem Cells for Peyronie's Disease, ED, and Interstitial Cystitis
Status: RECRUITING
Conditions: Erectile Dysfunction|Peyronie's Disease|Interstitial Cystitis
Interventions: BIOLOGICAL: AlloRx
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Web-Based Coping and Communication Skills Intervention in Improving Psychological Adaptation in Patients With Gynecological Cancer
Status: WITHDRAWN
Conditions: Endometrial Carcinoma|Stage 0 Fallopian Tube Cancer AJCC v7|Stage I Fallopian Tube Cancer AJCC v6 and v7|Stage I Ovarian Cancer AJCC v6 and v7|Stage IA Fallopian Tube Cancer AJCC v6 and v7|Stage IA Ovarian Cancer AJCC v6 and v7|Stage IB Fallopian Tube Cancer AJCC v6 and v7|Stage IB Ovarian Cancer AJCC v6 and v7|Stage IC Fallopian Tube Cancer AJCC v6 and v7|Stage IC Ovarian Cancer AJCC v6 and v7|Stage II Cervical Cancer AJCC v7|Stage II Fallopian Tube Cancer AJCC v6 and v7|Stage II Ovarian Cancer AJCC v6 and v7|Stage II Uterine Corpus Cancer AJCC v7|Stage IIA Cervical Cancer AJCC v7|Stage IIA Fallopian Tube Cancer AJCC v6 and v7|Stage IIA Ovarian Cancer AJCC V6 and v7|Stage IIA1 Cervical Cancer AJCC v7|Stage IIA2 Cervical Cancer AJCC v7|Stage IIB Cervical Cancer AJCC v6 and v7|Stage IIB Fallopian Tube Cancer AJCC v6 and v7|Stage IIB Ovarian Cancer AJCC v6 and v7|Stage IIC Fallopian Tube Cancer AJCC v6 and v7|Stage IIC Ovarian Cancer AJCC v6 and v7|Stage III Cervical Cancer AJCC v6 and v7|Stage III Fallopian Tube Cancer AJCC v7|Stage III Ovarian Cancer AJCC v6 and v7|Stage III Primary Peritoneal Cancer AJCC v7|Stage III Uterine Corpus Cancer AJCC v7|Stage IIIA Cervical Cancer AJCC v6 and v7|Stage IIIA Fallopian Tube Cancer AJCC v7|Stage IIIA Ovarian Cancer AJCC v6 and v7|Stage IIIA Primary Peritoneal Cancer AJCC v7|Stage IIIA Uterine Corpus Cancer AJCC v7|Stage IIIB Cervical Cancer AJCC v6 and v7|Stage IIIB Fallopian Tube Cancer AJCC v7|Stage IIIB Ovarian Cancer AJCC v6 and v7|Stage IIIB Primary Peritoneal Cancer AJCC v7|Stage IIIB Uterine Corpus Cancer AJCC v7|Stage IIIC Fallopian Tube Cancer AJCC v7|Stage IIIC Ovarian Cancer AJCC v6 and v7|Stage IIIC Primary Peritoneal Cancer AJCC v7|Stage IIIC Uterine Corpus Cancer AJCC v7|Stage IIIC1 Uterine Corpus Cancer AJCC v7|Stage IIIC2 Uterine Corpus Cancer AJCC v7|Stage IV Cervical Cancer AJCC v6 and v7|Stage IV Fallopian Tube Cancer AJCC v6 and v7|Stage IV Ovarian Cancer AJCC v6 and v7|Stage IV Primary Peritoneal Cancer AJCC v7|Stage IV Uterine Corpus Cancer AJCC v7|Stage IVA Cervical Cancer AJCC v6 and v7|Stage IVA Uterine Corpus Cancer AJCC v7|Stage IVB Cervical Cancer AJCC v6 and v7|Stage IVB Uterine Corpus Cancer AJCC v7|Uterine Carcinosarcoma|Uterine Corpus Sarcoma
Interventions: OTHER: Internet-Based Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Swiss Prospective, Multicenter Study Sentinel Lymph Node Procedure in Colon Cancer
Status: COMPLETED
Conditions: Colonic Neoplasms
Interventions: PROCEDURE: Sentinel lymph node procedure|PROCEDURE: Bone marrow aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Dose Ascending, Study To Examine The Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of GSK233705B.
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK233705B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Sars-cov-2 on Donor Oocyte Quality and Quantity, a Multicenter Retrospective Study.
Status: COMPLETED
Conditions: Ovarian Reserve|SARS-CoV-2 Infection|Blastocyst
Interventions: BIOLOGICAL: Sars Cov 2 infection|BIOLOGICAL: Sars Cov 2 vaccination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Orange-III Trial: Optimised Recovery With Movicol® Preoperatively Within an Enhanced Recovery Programme
Status: UNKNOWN
Conditions: Liver Diseases
Interventions: DRUG: Movicol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Pulpotomy Using TheraCal Versus MTA on Survival Rate of Cariously-Exposed Vital Permanent Molars
Status: COMPLETED
Conditions: Caries, Dental
Interventions: DRUG: MTA-Anglus|DRUG: TheraCal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SAD, MAD and Food Effect Evaluation of Safety, Tolerability, and PK of AQ280 in Healthy Subjects
Status: COMPLETED
Conditions: Eosinophilic Esophagitis (EoE)
Interventions: DRUG: AQ280|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Alzheimer Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer Disease
Interventions: DEVICE: Active TMS|BEHAVIORAL: CILT|DEVICE: Sham TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Trial of VR-CHOP in Lymphoma Patients
Status: COMPLETED
Conditions: Lymphoma, B-Cell|Follicular Lymphoma
Interventions: DRUG: Bortezomib|BIOLOGICAL: Rituximab|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Vincristine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of HS-20089 in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: HS-20089 (Phase Ia：Dose escalation )|DRUG: HS-20089 (Phase Ib: Dose expansion)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intra Oral Cryotherapy in Patients With Symptomatic Apical Periodontitis
Status: COMPLETED
Conditions: Post Operative Pain|Inflammation
Interventions: PROCEDURE: intraoral cryotherapy,ice gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DVD-based HIV/HCV Prevention Intervention for Drug-Involved Latino Criminal Justice Clients
Status: COMPLETED
Conditions: Human Immunodeficiency Virus|Acquired Immunodeficiency Syndrome|Hepatitis C
Interventions: BEHAVIORAL: DVD Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Scalp Cooling in MBC
Status: RECRUITING
Conditions: Metastatic Breast Cancer|Chemotherapy-induced Alopecia
Interventions: DEVICE: Paxman Scalp Cooling System|DRUG: Eribulin|DRUG: Sacituzumab govitecan|DRUG: Trastuzumab deruxtecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Extracorporeal Photopheresis (ECP) After Lung Transplantation
Status: COMPLETED
Conditions: Lung Transplant Infection|Lung Transplant Rejection
Interventions: DEVICE: ECP (Extracorporeal Photopheresis System)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Cohort Study of Knee Arthroplasty Assisted by Digital Technology
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: conventional intrumentation assisted knee arthroplasty|PROCEDURE: computer navigation assisted knee arthroplasty|PROCEDURE: robotic system assisted knee arthroplasty|PROCEDURE: patient-spercific assisted knee arthroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: AK112 and AK104 With or Without Chemotherapy in Advanced Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Advanced Non-small-cell Lung Cancer
Interventions: DRUG: AK112|DRUG: AK104|DRUG: Carboplatin|DRUG: paclitaxel|DRUG: pemetrexed|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CC-99677 in Participants With Active Ankylosing Spondylitis
Status: TERMINATED
Conditions: Spondylitis, Ankylosing
Interventions: DRUG: CC-99677|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Mental and Physical Health and Decreasing Hospital Readmission After Pancreatectomy Through Enhanced Patient and Caregiver Education and Engagement
Status: TERMINATED
Conditions: Pancreatectomy
Interventions: OTHER: SAFECARE at Home customized lessons
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Trial With Aconite Pain Oil in Oncology Patients Under Chemotherapy to Prevent CIPN Grade-II, to Reduce Symptoms and to Improve the Quality of Life of Patients With CIPN
Status: RECRUITING
Conditions: Chemotherapy-induced Polyneuropathy
Interventions: DRUG: Aconite pain oil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Requirement of External Laryngeal Manipulation in Double Lumen Tube Insertion With McGrath Laryngoscope vs Macintosh Laryngoscope. A Randomized Control Trial
Status: COMPLETED
Conditions: Intubation Complication
Interventions: DEVICE: Use of macintosh laryngoscope|DEVICE: Use of mcGarth laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Adipose Derived Mesenchymal Stem Cells for Induction of Remission in Perianal Fistulizing Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: OTHER: Cx601|OTHER: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Single Dose Fosfomycin and Single Dose Levofloxacin as Pre-urodynamic Antibiotic for UTI Prevention
Status: COMPLETED
Conditions: Urological System Complication of Procedure|Urinary Tract Infections
Interventions: DRUG: Fosfomycin 3000 MG|DRUG: Levofloxacin 500mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability of Intravenous SPM 927 as Replacement for Oral SPM 927 in Subjects With Partial Seizures
Status: COMPLETED
Conditions: Epilepsies, Partial
Interventions: DRUG: SPM 927
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Diathermy and Therapeutic Exercise Protocol in Women With Abdominal Diastasis
Status: RECRUITING
Conditions: Abdominal Diastasis
Interventions: OTHER: Diathermy + exercise group|OTHER: Diathermy placebo + exercise group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Registry on the EXperience of Extracorporeal CO2 Removal in Intensive Care Units
Status: UNKNOWN
Conditions: Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease|Patients With Acute Respiratory Distress Syndrome
Interventions: DEVICE: ECCO2R
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rho Kinase (ROCK) Inhibitor in Tauopathies - 1
Status: UNKNOWN
Conditions: Progressive Supranuclear Palsy|Corticobasal Syndrome
Interventions: DRUG: Fasudil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-arm Optimization of Stroke Thrombolysis
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Argatroban|DRUG: Eptifibatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Butyrate in Children With IBS: Double Blind Placebo Controlled Randomized Clinical Trial
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome (IBS)|Children, Only
Interventions: DIETARY_SUPPLEMENT: Dibuzin|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Association Between Unprotected Standing, Walking and Wound Healing in Diabetes
Status: COMPLETED
Conditions: Diabetic Foot
Interventions: DEVICE: Removable cast walker|DEVICE: Irremovable cast walker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of 2 Techniques of Invasive Mini Surgery: Coelioscopy Mini-trocar and Monotrocar in the Adnexa no Carcinologic Surgery : Forward-looking Observational Study.
Status: COMPLETED
Conditions: Gynecologic Surgical Procedures for Adnexa Surgery in Ovarian Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ESWT for UE Pain in Patients With Cervical Spinal Cord Injury
Status: TERMINATED
Conditions: Spastic Tetraplegia|Pain|Myelopathy Cervical
Interventions: DEVICE: Extracorporeal shockwave therapy|DEVICE: Sham therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilocarpine After Combined Cataract/Trabectome Surgery
Status: WITHDRAWN
Conditions: Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Pilocarpine|DRUG: Ofloxacin|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cost-effectiveness and Efficacy of Different Physical Exercise Interventions (ExerMOT4Health)
Status: ACTIVE_NOT_RECRUITING
Conditions: Physical Inactivity|Healthy Aging|Older Adult
Interventions: BEHAVIORAL: Supervised synchronous online exercise intervention without motivational strategies|BEHAVIORAL: Supervised synchronous online exercise intervention with motivational strategies|BEHAVIORAL: Supervised face to face exercise intervention without motivational strategies|BEHAVIORAL: Supervised face to face exercise intervention with motivational strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Efficacy and Safety of Subcutaneous Sonelokimab Compared With Placebo in Adult Participants With Moderate to Severe Hidradenitis Suppurativa
Status: RECRUITING
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: Sonelokimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Effectiveness of Adefovir Dipivoxil Plus Indinavir Combined With Zidovudine or Lamivudine or Stavudine in HIV-Infected Patients Who Have Not Taken Anti-HIV Drugs
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Indinavir sulfate|DRUG: Levocarnitine|DRUG: Adefovir dipivoxil|DRUG: Lamivudine|DRUG: Stavudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Single Dose Study of LY3023703 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: LY3023703|DRUG: Placebo|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase I Trial Using Cyclophosphamide, Rituximab and Revlimid (CR2) for the Treatment of Relapsed/Refractory B-Cell Chronic Lymphocytic Leukemia (B-CLL) and Small Lymphocytic Lymphoma (SLL)
Status: TERMINATED
Conditions: Leukemia, Lymphocytic, Chronic, B-Cell|Chronic Lymphocytic Leukemia|Lymphoma, Small Lymphocytic
Interventions: DRUG: Lenalidomide, Rituximab, and Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peg-interferon ADDed to an Ongoing Nucleos(t)Ide Based Treatment in Patients With Chronic Hepatitis B to Induce Decrease of HBs-Antigen
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: Pegylated interferon alfa-2a plus nucleos(t)ide(s)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Oral Stimulation and Non-nutritive Sucking Practices
Status: UNKNOWN
Conditions: Premature|Nutrition Disorders|Sucking Behavior
Interventions: OTHER: Pacifier|OTHER: Oral stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Adherence and Quality of Life of CPAP for Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: BEHAVIORAL: Motivational Interview (MI) & Adherence Follow-Up|BEHAVIORAL: Adherence Follow-Up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficiency of Schroth Method and Virtual Reality Exercises in Individuals With AIS
Status: RECRUITING
Conditions: Scoliosis; Adolescence|Scoliosis|Scoliosis Lumbar Region|Adolescent Idiopathic Scoliosis
Interventions: OTHER: Schroth Exercise Group|OTHER: Schroth Method Based Virtual Reality Group|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Myofascial Release With Tennis Ball on Spasticity and Motor Functions
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Myofascial release technique along with conventional physiotherapy exercises|OTHER: Conventional physiotherapy exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Three Hard Relining Materials in Complete Dentures
Status: COMPLETED
Conditions: Complete Mandibular Dentures With Poor Retention
Interventions: OTHER: Rebase II Fast|OTHER: Flexacryl|OTHER: Vertex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Ascending Multiple Dose Study of VTP-38543 in Adult Participants With Mild to Moderate Atopic Dermatitis
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: VTP-38543|OTHER: Vehicle with Transcutol®P|OTHER: Vehicle without Transcutol®P
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Intervention to Mitigate Post-Acute COVID-19 Syndrome
Status: NOT_YET_RECRUITING
Conditions: Post-Acute COVID-19 Syndrome|Fatigue
Interventions: OTHER: Dietary intervention to mitigate Post-Acute COVID-19 Syndrome|OTHER: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Radiation Therapy Plus Paclitaxel and Cisplatin in Treating Patients With Cervical Cancer
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: DRUG: cisplatin|DRUG: paclitaxel|RADIATION: brachytherapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of SC-006 and in Combination With ABBV-181 in Subjects With Advanced Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: SC-006|DRUG: ABBV-181
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Loading Speed and Intensity During Exercise on the Immediate Structural Changes in the Achilles Tendon
Status: COMPLETED
Conditions: Achilles Tendinopathy
Interventions: OTHER: Slow and heavy exercise therapy|OTHER: Slow and light exercise therapy|OTHER: Fast and heavy exercise therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Probe-based Confocal Laser Endomicroscopy, White-light Endoscopy and Virtual Chromoendoscopy
Status: UNKNOWN
Conditions: Intestinal Metaplasia|Intestinal Dysplasia
Interventions: PROCEDURE: Gastroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase II Study of Neoadjuvant Sacituzumab Govitecan and Pembrolizumab Therapy for Immunochemotherapy-resistant Early-stage Triple-negative Breast Cancer (TNBC)
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Sacituzumab Govitecan|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: DEVICE: Experimental Mouth Rinse 12027-033|OTHER: Placebo Mouth Rinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 68Ga DOTATATE PET/CT in Neuroendocrine Tumors (Expanded Access)
Status: NO_LONGER_AVAILABLE
Conditions: Carcinoid Cancer|Neuroendocrine Tumors|Medullary Thyroid Cancer|Cancers Expressing Somatostatin Receptors
Interventions: DRUG: 68Ga DOTATATE
Study Type: EXPANDED_ACCESS
Clinical trial: Honey Products for Cancer Patients With Oral Mucositis: a Randomized Controlled Trial
Status: UNKNOWN
Conditions: Oral Mucositis
Interventions: DIETARY_SUPPLEMENT: honey|DIETARY_SUPPLEMENT: propolis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Telerehabilitation-Based Respiratory Exercise Programs on Lung Capacity
Status: NOT_YET_RECRUITING
Conditions: Breathing Exercises|Telerehabilitation
Interventions: OTHER: Non-Instrumental breathing exercise group|OTHER: Instrumental breathing exercise group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: HygiRelief Procedure and HygiSample Evaluation for Functional Constipation
Status: WITHDRAWN
Conditions: Rome IV Functional Constipation
Interventions: DEVICE: HygiPrep (HyGIeaCare System)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib in Treating Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: sorafenib tosylate|OTHER: pharmacological study|PROCEDURE: assessment of therapy complications|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Cervical Epidural Injection and Selective Nerve Root Block
Status: COMPLETED
Conditions: Cervical Radiculopathy
Interventions: PROCEDURE: Interlaminar cervical epidural injection|PROCEDURE: Cervical selective nerve root block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Continuous Intravenous Infusion of Lidocaine on PPCs and Prognosis in Emergency Surgical Patients With IAI
Status: ACTIVE_NOT_RECRUITING
Conditions: Postoperative Pulmonary Complications|Intra-abdominal Infection
Interventions: DRUG: Lidocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of 6 Weeks TOTUM-070 on Lipid Metabolism and Cardiovascular Health in Individuals at Increased Cardio-metabolic Risk
Status: TERMINATED
Conditions: Hypercholesterolemia|Cardiovascular Risk Factor|Dyslipidemias|Atherosclerosis|Cardio-metabolic Risk
Interventions: DIETARY_SUPPLEMENT: TOTUM-070
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Early Access to Cabazitaxel in Patients With Metastatic Hormone Refractory Prostate Cancer Previously Treated With a Docetaxel-containing Regimen
Status: COMPLETED
Conditions: Prostate Cancer Metastatic
Interventions: DRUG: CABAZITAXEL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SAHaRA: A Randomized Controlled Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Subarachnoid Hemorrhage, Aneurysmal
Interventions: OTHER: Liberal RBC Transfusion Strategy|OTHER: Restrictive RBC Transfusion Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Awake Prone Positioning in COVID-19 Suspects With Hypoxemic Respiratory Failure
Status: COMPLETED
Conditions: COVID-19 Patients|Hypoxemic Respiratory Failure|Prone Position
Interventions: OTHER: PRONE POSITION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adherence in Patients Receiving PegIntron and Rebetol for Hepatitis C in Conjunction With a Patient Assistance Program (Study P04206)
Status: TERMINATED
Conditions: Hepatitis C, Chronic|Hepacivirus
Interventions: BIOLOGICAL: Peginterferon alfa-2b (SCH 54031)|DRUG: Ribavirin (SCH 18908)|BEHAVIORAL: Patient assistance program
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Paroxetine-referenced Study Evaluating Three Doses of DVS SR in Outpatients With MDD
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: DVS SR|DRUG: Paroxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Smoflipid to Soy-based Lipid Reduction for Cholestasis Prevention in Surgical Neonates
Status: COMPLETED
Conditions: Cholestasis of Parenteral Nutrition
Interventions: DRUG: Smoflipid 20% Lipid Emulsion for Injection|DRUG: Intralipid, 20% Intravenous Emulsion|DRUG: Intralipid, 20% Intravenous Emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Contrast Enhanced Spectral Mammography With Digital Breast Tomosynthesis For Patients With Newly Diagnosed Breast Cancer
Status: COMPLETED
Conditions: Breast Carcinoma
Interventions: OTHER: Contrast Agent|PROCEDURE: Digital Tomosynthesis Mammography|PROCEDURE: Dual-Energy Contrast-Enhanced Digital Spectral Mammography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study With Trabectedin in BRCA1 and BRCA2 Mutation Carrier and BRCAness Phenotype Ovarian Cancer
Status: UNKNOWN
Conditions: BRCA1 and BRCA2 Mutation Carrier and BRCAness Phenotype
Interventions: DRUG: Trabectedin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endovascular Revascularization With Solitaire Device Versus Best Medical Therapy in Anterior Circulation Stroke Within 8 Hours
Status: TERMINATED
Conditions: Acute Stroke
Interventions: DEVICE: Solitaire FR device|OTHER: Medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Stem Cell Small Extracellular Vesicles in Patients With Retinitis Pigmentosa
Status: RECRUITING
Conditions: Retinitis Pigmentosa
Interventions: BIOLOGICAL: GMP compliant-BM-MSC derived sEVs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Er:YAG Ablative Fractional Laser Assisted-Photodynamic Therapy Versus Photodynamic Therapy for Basal Cell Carcinoma
Status: COMPLETED
Conditions: Nodular Basal Cell Carcinoma
Interventions: PROCEDURE: Er:YAG AFL-PDT|PROCEDURE: MAL-PDT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Empagliflozin as a Treatment for Severe Congenital Neutropenia Due to G6PC3 Deficiency
Status: RECRUITING
Conditions: Crohn's Disease|Glycogen Metabolism|Inflammatory Bowel Disease (IBD)
Interventions: DRUG: Empagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Administration of L-arginine vs. Placebo in Patients Diagnosed With Presbyvestibulopathy.
Status: WITHDRAWN
Conditions: Presbyvestibulopathy
Interventions: DRUG: L-arginine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Ranging Study Of GW640385 Boosted With Ritonavir (Rtv) In Comparison To A RTV-Boosted Protease Inhibitor (PI) In HIV-1 Infected PI-Experienced Adults
Status: TERMINATED
Conditions: Infection, Human Immunodeficiency Virus I|HIV-1 Infection
Interventions: DRUG: Physician determined comparator PI + ritonavir|DRUG: GW640385 + ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PENG Block and Lateral Femoral Cutaneous Nerve Block For Hip Replacement Surgery
Status: COMPLETED
Conditions: POSTOPERATIVE ANALGESIA
Interventions: PROCEDURE: PERICAPSULAR NERVE GROUP BLOCK COMBINED WITH LATERAL FEMORAL CUTANEOUS NERVE BLOCK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: EMPOWER Clinical Trial: Vagal Blocking for Obesity Control
Status: COMPLETED
Conditions: Obesity
Interventions: DEVICE: Therapy ON|DEVICE: Therapy OFF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Pharyngeal Anesthesia in Sedated Esophagogastroduodenoscopy
Status: UNKNOWN
Conditions: Esophagogastroduodenoscopy
Interventions: PROCEDURE: Topical lidocaine pharyngeal anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Liposomal Bupivacaine Injection in Primary Total Knee Arthroplasty
Status: WITHDRAWN
Conditions: Osteoarthritis|Osteoarthritis, Knee|Arthritis, Degenerative|Osteoarthrosis|Osteoarthrosis Deformans
Interventions: DRUG: Bupivacaine Liposome Injection|DRUG: Indwelling femoral nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Assessment of the Absorption of Estradiol in Postmenopausal Women With Atrophic Vaginitis
Status: COMPLETED
Conditions: Menopause|Postmenopausal Vaginal Atrophy
Interventions: DRUG: estradiol, 10 mcg|DRUG: estradiol, 25 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Ezetimibe Treatment on Low-density Lipoprotein Cholesterol (LDL-C) Levels in Participants With Coronary Heart Disease (CHD) Already Treated With a Statin (MK-0653A-205 AM1)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Ezetimibe
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Elotuzumab in Combination With Pomalidomide and Low Dose Dexamethasone and Elotuzumab in Combination With Nivolumab in Patients With Multiple Myeloma Relapsed or Refractory to Prior Treatment With Lenalidomide.
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Elotuzumab|DRUG: Pomalidomide|DRUG: Dexamethasone|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing a Treatment Clustering System for Obstructive Sleep Apnea Using Polysomnographic Physiological Signals
Status: RECRUITING
Conditions: Obstructive Sleep Apnea of Adult
Interventions: OTHER: Control Group|PROCEDURE: Surgical Intervention|OTHER: Oropharyngeal Training (face-to-face)|OTHER: Oropharyngeal Training (telerehabilitation)|DEVICE: Continuous Positive Airway Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: REDUCED 1 - Renal Denervation Using Ultrasonic Catheter EmitteD Energy Study /
Status: ACTIVE_NOT_RECRUITING
Conditions: Uncontrolled Stage 2 Hypertension
Interventions: DEVICE: Renal denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Single Incision Laparoscopic Cholecystectomy in the Treatment of Patients With Acute Cholecystitis
Status: RECRUITING
Conditions: Cholecystectomy, Laparoscopic
Interventions: PROCEDURE: Open cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exercising Our ABC's (African- American Breast Cancer Survivors)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Resistance Exercise|BEHAVIORAL: Aerobic Exercise|BEHAVIORAL: Behavioral Group Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nurtured Heart Parenting Intervention for Child Behavioural Problems
Status: COMPLETED
Conditions: Parent-Child Relations|Child Behavior Problem
Interventions: BEHAVIORAL: Transforming the Intense Child Workbook (Glasser, 2016)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PENG Block vs Sciatico Femoral Block in the Incidence of Post Amputation Syndroms
Status: RECRUITING
Conditions: Femoral Nerve Block|Amputation of Knee
Interventions: PROCEDURE: peri capsular nerve group block|PROCEDURE: scaitico femoral block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT