pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Protective Role of Pre-/ Post-biotics on Gut Inflammation, Dysbiosis, and Life Quality in Rett Syndrome (Biotics_RTT)
Status: COMPLETED
Conditions: Rett Syndrome|Dysbiosis|Epilepsy|Quality of Life
Interventions: DIETARY_SUPPLEMENT: ALAC, inulin, FOS, and sodium butyrate|DIETARY_SUPPLEMENT: Sodium butyrate and zinc oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeting the Endothelial Glycocalyx to Enhance Vascular Function and Exercise-Induced Vascular Adaptations in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Endocalyx|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Tamsulosin in the Treatment of Ureteral Stones in Emergency Department Patients
Status: COMPLETED
Conditions: Nephrolithiasis|Ureteral Calculi
Interventions: DRUG: tamsulosin|DRUG: Standard therapy with ibuprofen and oxycodone.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept, Twice Daily Applications of LEO 124249 Ointment in the Treatment of Chronic Hand Eczema
Status: COMPLETED
Conditions: Hand Eczema
Interventions: DRUG: LEO 124249 ointment|DRUG: LEO 124249 ointment vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Ranging Study of Arformoterol Given Once Daily Compared to Arformoterol Given Twice Daily in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Arformoterol tartrate inhalation solution|DRUG: Arformoterol tartrate inhalation solution|DRUG: Arformoterol tartrate inhalation solution|DRUG: Placebo|DRUG: Arformoterol tartrate inhalation solution|DRUG: Arformoterol tartrate inhalation solution|DRUG: Arformoterol tartrate inhalation solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Detection of Triple Negative Breast Cancer Relapse
Status: NOT_YET_RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: DIAGNOSTIC_TEST: ctDNA monitoring|DIAGNOSTIC_TEST: 68Ga-FAPI-46-PET-CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Efficacy and Safety of Armodafinil as Adjunctive Therapy in Adults With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: armodafinil|DRUG: placebo|DRUG: armodafinil|DRUG: armodafinil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness Study of CPI-613 to Treat Refractory or Relapsed Leukemia and Myelodysplastic Syndrome
Status: WITHDRAWN
Conditions: Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome (MDS)
Interventions: DRUG: CPI-613
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FOCUS:Families OverComing Under Stress
Status: COMPLETED
Conditions: Cancer|Depression|PostTraumatic Stress Disorder|Anxiety
Interventions: BEHAVIORAL: FOCUS Resilience Enhancement Program|BEHAVIORAL: Waitlist (No Study Treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intravenous Administration of Microplasmin for Treatment of Acute Ischemic Stroke
Status: COMPLETED
Conditions: Stroke, Acute
Interventions: DRUG: Microplasmin|DRUG: Microplasmin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of E-cigarettes for Smoking Cessation in Middle-aged Heavy Smokers
Status: COMPLETED
Conditions: Smoking Cessation|Electronic Cigarette
Interventions: DRUG: Nicotine|DRUG: Varenicline Tartrate|BEHAVIORAL: Motivational Interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Chlorhexidine Solution in Preventing Peripheral Venous Catheter Associated-Infection
Status: COMPLETED
Conditions: Catheter-Associated Infections
Interventions: OTHER: Effects of Chlorhexidine Solutions with Different Concentrations in Preventing Peripheral Venous Catheter-Associated Infections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Royal Vaginal Gel Compared to IUI Technique on Fertility Rate of Women With Low-fertility Husbands
Status: COMPLETED
Conditions: Asthenozoospermia
Interventions: OTHER: Royal jelly|PROCEDURE: IUI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Interferon Free Regimens in Patients With Chronic HCV and Successfully Treated HCC
Status: UNKNOWN
Conditions: Hepatitis C, Chronic|Hepatocellular Carcinoma
Interventions: DRUG: Sofosbuvir|DRUG: Ribavirin|DRUG: Simeprevir|DRUG: daclatasvir|DRUG: Ledipasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Active Surveillance in Low-Risk Prostate Cancer: a Pilot Study
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BEHAVIORAL: web-based tool (MAP- Management of Active surveillance in Prostate Cancer)|BEHAVIORAL: MUSIC website
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Radiographic and Clinical Comparison of Post-reduction Splinting Constructs in the Treatment of Acute Displaced Distal Radius Fractures
Status: COMPLETED
Conditions: Radius Fractures
Interventions: OTHER: Sugar Tong Splint|OTHER: Clam Shell Splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMA970A Plus CV8102 in Very Early, Early and Intermediate Stage Hepatocellular Carcinoma Patients
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: IMA970A plus CV8102 and Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Closed-loop Anesthesia in Pediatric Patients
Status: TERMINATED
Conditions: Anesthesia
Interventions: DRUG: Propofol|DRUG: remifentanil|DRUG: Propofol|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Grief Therapy Approaches for Bereaved Parents
Status: RECRUITING
Conditions: Grief|Bereavement|Cancer
Interventions: BEHAVIORAL: Meaning-Centered Grief Therapy|BEHAVIORAL: Supportive Psychotherapy|BEHAVIORAL: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Food Study of Glipizide and Metformin HCl Tablets 5 mg/500 mg to Metaglip® Tablets 5 mg/500 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Glipizide and Metformin HCl Tablets 5 mg/500 mg|DRUG: Metaglip® Tablets 5 mg/500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Study of Translocated Internal Limiting Membrane Flap Reposition for the Treatment of Idiopathic Macular Hole
Status: RECRUITING
Conditions: Macular Holes
Interventions: PROCEDURE: Translocation ILM Flap|PROCEDURE: ILM Peeling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Observational Study of Emergence and Hypoactive Delirium After Anesthesia
Status: NOT_YET_RECRUITING
Conditions: Emergence Delirium|Hypoactive Delirium|Pain
Interventions: DEVICE: noninvasive blood pressure, 3 lead ECG, peripheral oxygen saturation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of ARI-3037MO to Reduce Triglyceride Levels in Adults With Severe (≥500 mg/dl) Hypertriglyceridemia
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DRUG: ARI-3037MO|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The UPDATE Trial (Uvb Phototherapy in Dermatology for ATopic Eczema)
Status: RECRUITING
Conditions: Atopic Dermatitis Eczema|Atopic Dermatitis
Interventions: DEVICE: NB-UVB phototherapy|COMBINATION_PRODUCT: Optimal topical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab(MEDI4736) After chemoRadioTherapy(DART) for NSCLC-a Translational and Biomarker Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer|Non Small Cell Lung Cancer|Non Small Cell Lung Cancer Stage III|NSCLC|NSCLC, Stage III
Interventions: DRUG: Durvalumab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Research Study Comparing a New Medicine "Fast-acting Insulin Aspart" to Another Already Available Medicine "NovoRapid"/"NovoLog" in People With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: Faster-acting insulin aspart|DRUG: Insulin aspart|DRUG: Insulin degludec|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety And Pharmacology Study Of SNX-5422 Mesylate In Subjects With Refractory Solid Tumor Malignancies
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: SNX-5422
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aloxi for Prevention of Chemotherapy Induced Nausea and Vomiting in Malignant Glioma Patients Receiving Irinotecan With Bevacizumab
Status: TERMINATED
Conditions: Brain Cancer
Interventions: DRUG: Palonosetron (Aloxi) and Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Extracorporeal Shock Wave Therapy Versus Functional Electrical Stimulation on Spasticity, Function and Gait Parameters in Hemiplegic Cerebral Palsy
Status: COMPLETED
Conditions: Children With Cerebral Palsy
Interventions: OTHER: Physical therapy program|DEVICE: Extracorporeal shock wave therapy|DEVICE: Functional electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate Tolerability and Efficacy of MK5172 / MK8742 Without Ribavirin for 12 Weeks in Patients With Chronic HCV G1b Infection With Compensated Cirrhosis
Status: UNKNOWN
Conditions: Hepatitis C|Compensated Cirrhosis
Interventions: DRUG: MK5172 /MK8742
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Capacity of a Camera to Identify Signs of Arteriosclerosis in Retinal Arterioles
Status: COMPLETED
Conditions: Arteriosclerosis
Interventions: DEVICE: MHRC: Metabolic Hyperspectral Retinal Camera
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Medacta International AMIStem-P Post-Marketing Surveillance Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Arthrosis|Traumatic Arthritis|Rheumatoid Polyarthritis|Congenital Hip Dysplasia|Avascular Necrosis of the Femoral Head
Interventions: DEVICE: AMIStem-P
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Transdermal Testosterone and/or Monthly Vitamin D on Fall Risk in Pre--frail Hypogonadal Seniors
Status: TERMINATED
Conditions: Hypogonadism|Pre-frail Seniors
Interventions: DRUG: Testosterone|DRUG: Colecalciferol|DRUG: Placebo drink solution|DRUG: Placebo transdermal gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GAPcare: The Geriatric Acute & Post-acute Care Coordination Program for Fall Prevention in the Emergency Department
Status: COMPLETED
Conditions: Falls (Accidents) in Old Age
Interventions: BEHAVIORAL: GAPcare intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Progression Assessment of Carotid Artery Stenosis by Ultrafast Ultrasound Flow Imaging
Status: RECRUITING
Conditions: Carotid Artery Stenosis
Interventions: DIAGNOSTIC_TEST: Ultrasound-based flow imaging|DIAGNOSTIC_TEST: Ultrasound-based strain imaging|DIAGNOSTIC_TEST: Conventional duplex
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Two Glucocorticoid Regimens in the Treatment of Sarcoidosis
Status: COMPLETED
Conditions: Sarcoidosis
Interventions: DRUG: Low dose prednisolone|DRUG: Medium dose prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of 24-hour Infusion of ON 01910.Na in Combination With Gemcitabine in Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: ON 01910.Na|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prediction of Intraventricular Hemorrhage Using Echocardiography and Near Infrared Spectroscopy
Status: RECRUITING
Conditions: Intraventricular Hemorrhage of Newborn Grade 2|Intraventricular Hemorrhage of Newborn Grade 3|Intraventricular Haemorrhage Grade IV
Interventions: DIAGNOSTIC_TEST: Cerebral near-infrared spectroscopy|DIAGNOSTIC_TEST: Functional echocardiography|DIAGNOSTIC_TEST: Head Ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Efficacy and Safety of Silodosin in the Treatment of the Signs and Symptoms of BPH
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: Silodosin|DRUG: Tamsulosin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CICATRIX in the Treatment of Hypertrophic Scars and Keloids Scars
Status: COMPLETED
Conditions: Hypertrophic Scars|Keloids
Interventions: OTHER: Cicatrix|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study for Hyalobarrier to Evaluate Anti-adhesive Effect and Safety Compared to Guardix-SG After Thyroidectomy
Status: COMPLETED
Conditions: Thyroid Disease
Interventions: DEVICE: Hyalobarrier|DEVICE: Guardix-SG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Addressing Diffusion of Responsibility and Prescribing Burden to Improve Use of Diabetes Medications
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes|SGLT-2i and GLP-1RA Therapies|Diffusion of Responsibility|Prescribing Burden
Interventions: BEHAVIORAL: Intervention to address diffusion of responsibility|BEHAVIORAL: Intervention to address diffusion of responsibility + simplification of prescribing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Venous Thromboembolism and Haemostatic Disturbances in Patients With Upper Gastrointestinal Cancer
Status: COMPLETED
Conditions: Thrombosis|Deep Venous Thrombosis|Pulmonary Embolism|Venous Thromboembolism|Pancreas Cancer|Esophagus Cancer|Gastric Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Screening and Multiple Intervention on Lung Epidemics
Status: ACTIVE_NOT_RECRUITING
Conditions: Inflammation|Smoking Cessation|Diet Modification|Physical Activity|Lung Cancer
Interventions: DRUG: Cytisine|DRUG: Acetylsalicylic acid|OTHER: Diet Modification and Physical Activity Increase|DIAGNOSTIC_TEST: early lung cancer detection|DIAGNOSTIC_TEST: spirometry with CO test|OTHER: anthropometic data collection|OTHER: blood test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Vaniprevir (MK-7009) With Pegylated Interferon (Peg-IFN) and Ribavirin (RBV) in Treatment-Experienced Hepatitis C Virus (HCV) Participants (MK-7009-009)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Vaniprevir|DRUG: Pegylated Interferon (Peg-IFN)|DRUG: Ribavirin (RBV)|DRUG: Placebo (PBO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PEEK and Allograft Spacers Evaluation in Spinal Fusion Surgeries
Status: COMPLETED
Conditions: Degenerative Disc Disease
Interventions: PROCEDURE: Posterior/Transforaminal Lumbar Interbody Fusion (P/TLIF), Anterior Cervical Discectomy and Fusion (ACDF)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Does Duloxetine Reduce Chronic Pain After Total Knee Arthroplasty?
Status: UNKNOWN
Conditions: Neuropathic Pain
Interventions: DRUG: Duloxetine|DRUG: celecoxib, naproxen/esomeprazole, acetaminophen/tramadol, oxycodone/naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Preoperative Supine Time for Adrenal Venous Sampling
Status: RECRUITING
Conditions: Primary Aldosteronism
Interventions: PROCEDURE: 15-min supine time|PROCEDURE: 2-hour supine time
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Cariprazine|DRUG: Placebo|DRUG: Antidepressant Therapy (ADT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of Ganetespib in Combination With Doxorubicin
Status: TERMINATED
Conditions: Cancer|Small Cell Lung Cancer
Interventions: DRUG: Ganetespib|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Alcohol on Cephalic Phase Reflex and Gene Expression
Status: COMPLETED
Conditions: Type 2 Diabetes|Inflammation|Carbohydrate&Lipid Metabolism|Oral Processing
Interventions: DIETARY_SUPPLEMENT: alcohol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long-term Safety and Tolerability of Subcutaneous Administration of TEV-48125 for the Preventive Treatment of Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: TEV-48125|DRUG: TEV-48125
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT of a Temporomandibular Joint Distraction Device for Patients With Articular Disorders Diagnosis
Status: UNKNOWN
Conditions: TMJ Disc Disorder|TMJ Pain|TMJ Sounds on Opening/Closing the Jaw|TMJ - Injury of Meniscus of Temporomandibular Joint
Interventions: DEVICE: TMJ Condilar Distraction Device|DEVICE: Conventional Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Maintenance Therapy
Status: COMPLETED
Conditions: Binge-Eating Disorder|Obesity
Interventions: DRUG: NB medication (Naltrexone Bupropion combination)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CAR-T Cells for Relapsed or Refractory Haematopoietic and Lymphoid Malignancies
Status: UNKNOWN
Conditions: Leukemia|Lymphoma|Multiple Myeloma of Bone (Diagnosis)
Interventions: BIOLOGICAL: Autologous CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Macular Edema Secondary to Branch Retinal Vein Occlusion
Status: COMPLETED
Conditions: Macular Edema|Branch Retinal Vein Occlusion
Interventions: DRUG: Faricimab|DRUG: Aflibercept|PROCEDURE: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Immunoglobulin (IVIG) for Resistant Neuropathic Pain
Status: UNKNOWN
Conditions: Neuropathic Pain
Interventions: BIOLOGICAL: Intravenous immunoglobulin|BIOLOGICAL: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-Invasive Identification of Endometrial Cancer/Endometrial Atypical Hyperplasia With an AI-Based Classifier Applied to Transvaginal Ultrasound in Patients With Post-Menopausal Bleeding
Status: RECRUITING
Conditions: Endometrial Carcinoma
Interventions: OTHER: Non-Interventional Study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Decitabine, Venetoclax, and Ponatinib for the Treatment of Philadelphia Chromosome-Positive Acute Myeloid Leukemia or Myeloid Blast Phase or Accelerated Phase Chronic Myelogenous Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Acute Myeloid Leukemia|Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Recurrent Acute Myeloid Leukemia|Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Refractory Acute Myeloid Leukemia|Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Interventions: DRUG: Decitabine|DRUG: Ponatinib|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cochlear Implant With Anti-Inflammatory Agent
Status: COMPLETED
Conditions: Hearing Loss
Interventions: DEVICE: Contour Advance electrode with controlled dose of dexamethasone base|DEVICE: Contour Advance electrode
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transitional Palliative Care in End-stage Heart Failure
Status: COMPLETED
Conditions: End Stage Heart Disease|Heart Failure
Interventions: BEHAVIORAL: Transitional Care Model|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of an Adapted ACT Group for Stroke & Brain Injury Survivors
Status: TERMINATED
Conditions: Stroke|Acquired Brain Injury|Acceptance and Commitment Therapy|Brain Injuries
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy (ACT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenomics in Pulmonary Arterial Hypertension
Status: WITHDRAWN
Conditions: Pulmonary Arterial Hypertension|Pulmonary Hypertension|PAH WHO Group I
Interventions: DRUG: Sitaxsentan|DRUG: Bosentan, Ambrisentan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Autogenous Tooth Graft for Ridge Augmentation
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Implant
Interventions: PROCEDURE: Maxillary Alveolar Ridge Augmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Conservative Management of HSIL in Patients With Future Pregnancy Aspiration
Status: RECRUITING
Conditions: Cervical Intraepithelial Neoplasia|Squamous Intraepithelial Lesions of the Cervix|Uterine Cervical Dysplasia
Interventions: DIAGNOSTIC_TEST: Conservative management with regular follow-up|PROCEDURE: Conization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MRI- Guided Transurethral Ultrasound Ablation of Localized Prostate Cancer
Status: COMPLETED
Conditions: MRI Guided Transurethral Ultrasound Ablation|Localized Prostate Cancer|Ablation Therapy
Interventions: PROCEDURE: Magnetic Resonance Imaging-Guided Transurethral Ultrasound Ablation of Prostate Tissue
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Preoxygenation Strategies in the Prehospital Environment
Status: COMPLETED
Conditions: Anesthesia|Hypoxia
Interventions: DEVICE: Continuous Positive Airway Pressure (CPAP)|DEVICE: Bag-Valve-Mask (BVM)|DEVICE: Non-rebreather Mask (NRM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Rehabilitation of the Upper Extremity With Enhanced Proprioceptive Feedback Following Incomplete Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury|Tetraplegia|Paresis|Plegia
Interventions: DEVICE: AMES treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Dovitinib in Recurrent and/or Metastatic Adenoid Cystic Carcinoma of the Salivary Glands
Status: COMPLETED
Conditions: Recurrent Adenoid Cystic Carcinoma of the Salivary Glands|Metastatic Adenoid Cystic Carcinoma of the Salivary Glands|Salivary Gland Cancers|ACC
Interventions: DRUG: Dovitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Efficacy of JCXH-211 in Patients With Recurrent or Progressive High-Grade Glioma
Status: NOT_YET_RECRUITING
Conditions: Recurrent or Progressive High-grade Glioma
Interventions: BIOLOGICAL: JCXH-211
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aerobic Exercise and Cognitive Training in Patients With Stroke
Status: RECRUITING
Conditions: Ischemic Stroke|Hemorrhagic Stroke
Interventions: BEHAVIORAL: Neuropsychological evaluation|BIOLOGICAL: BDNF evaluation|BEHAVIORAL: Pedaling as a moderate intensity aerobic exercise|OTHER: Cognitive Training|DIAGNOSTIC_TEST: VO2 assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Impact of Pyloric Injection of Magnesium Sulfate and Lidocaine Mixture on Outcome After Sleeve Gastrectomy
Status: COMPLETED
Conditions: Morbid Obesity
Interventions: PROCEDURE: Pyloric injection of magnesium sulfate and lidocaine mixture|PROCEDURE: Pyloric injection of saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy, Safety and Immunogenicity of SARS-CoV-2 Vaccine (Vero Cells), Inactivated in Healthy Adults Aged 18 Years and Older (COVID-19)
Status: UNKNOWN
Conditions: COVID-19
Interventions: BIOLOGICAL: SARS-CoV-2 Vaccine (Vero Cells), Inactivated|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Endovascular Treatment of Femoropopliteal Arterial Occlusive Lesion With Drug-Coated Balloon
Status: ACTIVE_NOT_RECRUITING
Conditions: Drug-coated Balloon|Femoropopliteal Artery Occlusion|Angioplasty
Interventions: DEVICE: Drug-coated Balloon
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Isoniazid on Protoporphyrin Levels in Erythropoietic Protoporphyria
Status: TERMINATED
Conditions: Erythropoietic Protoporphyria (EPP)|X Linked Erythropoietic Protoporphyria
Interventions: DRUG: Isoniazid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of 5% Monolaurin Vaginal Gel Administered Intravaginally for the Treatment of Bacterial Vaginosis
Status: COMPLETED
Conditions: Bacterial Vaginosis
Interventions: DRUG: 5% Monolaurin Vaginal Gel|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lymphatic Function in Patients With a Fontan-Kreutzer Circulation
Status: UNKNOWN
Conditions: Lymphatic Abnormalities|Lymphatic Edema|Univentricular Heart
Interventions: DIAGNOSTIC_TEST: Near Infrared Fluorescence Imaging|DIAGNOSTIC_TEST: Non-contrast MRI|DIAGNOSTIC_TEST: Strain Gauge Plethysmography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess the Metabolism and Elimination of [14C]-Labeled Varespladib Methyl in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: varespladib methyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Avastin (Bevacizumab) and Xeloda (Capecitabine) as Maintenance Treatment in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Bevacizumab|DRUG: Capecitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating The Absorption Of Varenicline Into The Body From A Varenicline Solution And A Varenicline Patch Applied To The Skin
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Varenicline free base solution|DRUG: Varenicline free base patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Hydrus Microstent and Lens Extraction for the Treatment of Primary Angle-Closure Glaucoma
Status: COMPLETED
Conditions: Primary Angle Closure Glaucoma|Primary Angle Closure
Interventions: DEVICE: Trabecular bypass and Schlemm's canal stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Chorioamnionitis After Delivery
Status: COMPLETED
Conditions: Chorioamnionitis
Interventions: DRUG: saline|DRUG: ampicillin gentamicin|DRUG: Ampicillin gentamicin clindamycin|DRUG: ampicillin gentamicin clindamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 1565nm Non-ablative Fractional Laser Treat Alopecia Areata
Status: RECRUITING
Conditions: Alopecia Areata
Interventions: PROCEDURE: 1565nm Non-ablative Fractional Laser|PROCEDURE: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irinotecan Followed By Fluorouracil and Leucovorin in Treating Patients With Stage III or Stage IV Colorectal Carcinoma (Cancer), Other Refractory Carcinoma, or Metastatic Adenoma (Cancer) of Unknown Primary Origin
Status: COMPLETED
Conditions: Carcinoma of Unknown Primary|Colorectal Cancer|Unspecified Adult Solid Tumor, Protocol Specific|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: fluorouracil|DRUG: irinotecan hydrochloride|DRUG: leucovorin calcium|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity (Non-inferiority) of a Purified Chick Embryo Cell Vaccine Vaccine Administered in Two Different Schedules (Conventional Versus Abbreviated Schedule)
Status: COMPLETED
Conditions: Rabies
Interventions: BIOLOGICAL: Abbreviated Zagreb 2-1-1 schedule|BIOLOGICAL: Standard Essen 1-1-1-1-1 schedule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Different Hemostasis According to the Anesthetic Agents
Status: COMPLETED
Conditions: Cataract|Retina Detachment|Pterygium|Keratitis|Vitreous Hemorrhage
Interventions: DRUG: Propofol, remifentanil|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Study Between Surgical and Non Surgical Treatment of Anismus in Patients
Status: COMPLETED
Conditions: Obstructed Defecation|Anismus|Constipation
Interventions: OTHER: BFD|PROCEDURE: PDPR|OTHER: BTX A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Monitoring of Azathioprine Metabolite Concentrations and Cytokine Levels in Neuromyelitis Optica Spectrum Disorder
Status: COMPLETED
Conditions: NMO Spectrum Disorder|Azathioprine Adverse Reaction
Interventions: DRUG: Azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduction of Oxygen After Cardiac Arrest
Status: UNKNOWN
Conditions: Out-of-Hospital Cardiac Arrest
Interventions: OTHER: target SpO2 98-100%|OTHER: target SpO2 90-94%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical And Translational Study Of MK-2206 In Patients With Metastatic KRAS-Wild-Type, PIK3CA-Mutated, Colorectal Cancer
Status: TERMINATED
Conditions: Colon Cancer|Rectal Cancer
Interventions: DRUG: MK-2206
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Management and Adherence Evaluation of Diclofenac in the Treatment of Knee Osteoarthritis Pain
Status: UNKNOWN
Conditions: To Investigate the Effect of Diclofenac on Pain Control of Knee Osteoarthritis and the Relationship Between Pain Relief and Medicine Adherence
Interventions: OTHER: regular follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Adding Dexmedetomidine Versus Ibuprofen as an Adjuvant to Intraperitoneal Bupivacaine for Pain Control After Laparoscopic Gynecological Procedures
Status: NOT_YET_RECRUITING
Conditions: Postoperative Pain, Acute
Interventions: DRUG: Administering intraperitoneal bupivacaine for pain control after laparoscopic gynecological procedures|DRUG: Administering intraperitoneal bupivacaine plus Dexmedetomidine for pain control after laparoscopic gynecological procedures|DRUG: Administering intraperitoneal bupivacaine plus Ibuprofen for pain control after laparoscopic gynecological procedures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Intra-articular Injections of Platelet-rich Plasma, Hyaluronic Acid, or Corticosteroids for Knee Osteoarthritis
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: BIOLOGICAL: Platelet-rich plasma|DRUG: Hyaluronic acid|DRUG: Methylprednisolone acetate injectable suspension (DEPO-MEDROL®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Innovative Trial for Understanding the Impact of Targeted Therapies in NF2-Related Schwannomatosis (INTUITT-NF2)
Status: RECRUITING
Conditions: Neurofibromatosis Type 2|Vestibular Schwannoma|Non-vestibular Schwannoma|Meningioma|Ependymoma
Interventions: DRUG: Brigatinib|DRUG: Neratinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Recovery of Muscle Function in the Arm/Hand After a Stroke
Status: COMPLETED
Conditions: Stroke|Hemiparesis
Interventions: OTHER: Simultaneous Bimanual training|OTHER: Conventional Occupational Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: NIRS for the Diagnosis and Prevention of Acute Renal Failure
Status: UNKNOWN
Conditions: Renal Insufficiency, Acute
Interventions: COMBINATION_PRODUCT: Optimization of the cardiac output, the temperature, the hemoglobin in order to have the NIRS value by up to 80%.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Recurrences After Standard EMR vs Plus Thermal Ablation EMR
Status: RECRUITING
Conditions: Polyps of Colon|Recurrence, Local Neoplasm
Interventions: PROCEDURE: Snare tip soft coagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-assisted Versus Conventional Landmark-guided Spinal Anesthesia in Patients With Abnormal Spinal Anatomy
Status: COMPLETED
Conditions: Anesthesia, Spinal|Ultrasonography|Scoliosis
Interventions: PROCEDURE: Ultrasound-assisted paramedian spinal anesthesia|PROCEDURE: Landmark-guided spinal anesthesia|DRUG: 0.5% heavy bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of BIA 5 1058 on Cardiac Repolarization
Status: COMPLETED
Conditions: Cardiovascular Disease|Pulmonary Arterial Hypertension|Heart Failure
Interventions: DRUG: BIA 5-1058|DRUG: Placebo Oral Tablet|DRUG: Moxifloxacin 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short-Term Alpha Lipoic Acid Therapy for Prevention of Contrast-induced Acute Kidney Injury and Endothelial Dysfunction in Type 2 Diabetes
Status: UNKNOWN
Conditions: Acute Kidney Injury|The Changes of Plasma Creatinine|The Changes of Plasma Free Radicals|The Changes of Endothelium-dependent Arterial Dilation
Interventions: DRUG: Alpha lipoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Clinical Research Protocol of Ferumoxytol for Magnetic Resonance Enhancement Imaging in Patients With Atherosclerosis.
Status: RECRUITING
Conditions: Atherosclerosis
Interventions: DRUG: Safety assessment of Ferumoxytol.|DRUG: Assessment of the diagnostic value of Ferumoxytol for MR angiography.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Investigate the Safety and Effect of Food on the Pharmacokinetics of YM178 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer|Pharmacokinetics of YM178
Interventions: DRUG: YM178
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Rituximab Plus Cyclophosphamide in Treating Patients With Indolent Stage III or Stage IV Non-Hodgkin's Lymphoma
Status: WITHDRAWN
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Pulses Consumption and Its Role in Managing Systemic Inflammation, Insulin Sensitivity and Gut Microbiome in Human
Status: ACTIVE_NOT_RECRUITING
Conditions: Insulin Sensitivity|Overweight or Obesity|Inflammatory Response
Interventions: OTHER: Control|OTHER: Black bean|OTHER: Chickpea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Cystic Fibrosis (CF) Exacerbation and Insulin Treatment
Status: UNKNOWN
Conditions: Cystic Fibrosis|Impaired Glucose Tolerance|Pulmonary Exacerbation
Interventions: DRUG: novorapid / humalog short acting insulin|DRUG: Novo Rapid Insulin (Novonordisk)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HealthySteps: Exercise for Older Adults With Mobility Limitation
Status: COMPLETED
Conditions: Mobility Limitation
Interventions: BEHAVIORAL: Timing and Coordination|BEHAVIORAL: Aerobic Walking|BEHAVIORAL: Stretching and Relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Multicenter, Randomized Study Comparing RIT Vs ASCT in Patients With Relapsed/Refractory (FL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed Follicular Lymphoma
Interventions: OTHER: ZEVALIN|DRUG: BEAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of 4 Dose Regimens of Oral Albaconazole in Subjects With Distal Subungual Onychomycosis
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DRUG: Albaconazole 100mg|DRUG: Albaconazole 200mg|DRUG: Albaconazole 400mg|DRUG: Albaconazole 400mg|DRUG: Placebo 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Faecal Microbiota Transplantation System for Treatment of Primary and Recurrent Clostridium Difficile Infection
Status: UNKNOWN
Conditions: Clostridium Difficile Infection
Interventions: BIOLOGICAL: faecal human microbiota transplant (FMT)|DRUG: Vancomycin or Fidaxomicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Low-intensity Laser and ESWT in Carpal Tunnel Syndrome
Status: NOT_YET_RECRUITING
Conditions: Carpal Tunnel Syndrome
Interventions: DEVICE: Extracorporeal shock wave therapy|DEVICE: Laser therapy|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cement Augmentation in Preventing Vertebral Body Compression Fracture Following Spine Stereotactic Radiosurgery in Patients With Solid Tumors and Spinal Metastases
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Malignant Neoplasm in the Spine|Metastatic Malignant Solid Neoplasm
Interventions: PROCEDURE: Management of Therapy Complications|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|RADIATION: Stereotactic Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Tetrathiomolybdate vs Standard Treatment in Primary Biliary Cirrhosis
Status: COMPLETED
Conditions: Primary Biliary Cirrhosis
Interventions: DRUG: Tetrathiomolybdate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Chromoendoscopy and Virtual Chromoendoscopy (NBI, I-scan, FICE) for Detection of Neoplasia in Long Standing Ulcerative Colitis
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DEVICE: Virtual chromoendoscopy|PROCEDURE: Chromoendoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Recruitment and Apheresis Collection of Peripheral Blood Hematopoietic Stem Cells, Mononuclear Cells and Granulocytes
Status: RECRUITING
Conditions: Granuloma|Granulomatous Disease, Chronic|Leukocyte Disease|Genetic Disease, X-Linked|Genetic Disease, Inborn
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prescription and Persistence of Antithrombotic Agents in Acute Ischemic Stroke or Transient Ischemic Attack Patients With MCA(Middle Cerebral Artery) Disease
Status: UNKNOWN
Conditions: MCA - Middle Cerebral Artery Dissection
Interventions: DRUG: Clopidogrel
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p