pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect Of Ketoconazole On The Pharmacokinetics Of Tasocitinib (CP-690,550) In Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tasocitinib (CP-690,55) plus Ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: REVEAL Study of NKTR-262 in Combination With NKTR-214 and Nivolumab in Patients With Locally Advanced / Metastatic Solid Tumor Malignancies
Status: TERMINATED
Conditions: Melanoma|Merkel Cell Carcinoma|Triple Negative Breast Cancer|Head and Neck Squamous Cell Carcinoma|Renal Cell Carcinoma|Colorectal Cancer|Sarcoma
Interventions: DRUG: NKTR-262|DRUG: bempegaldesleukin|DRUG: nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia in Remission
Status: WITHDRAWN
Conditions: Adult Acute Erythroid Leukemia|Adult Acute Monoblastic and Acute Monocytic Leukemia|Adult Acute Myeloid Leukemia
Interventions: DRUG: anti-thymocyte globulin|DRUG: fludarabine phosphate|DRUG: thiotepa|PROCEDURE: biological therapy|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: chemotherapy|PROCEDURE: non-specific immune-modulator therapy|PROCEDURE: peripheral blood stem cell transplantation|PROCEDURE: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A 12-Week Study of Topical Pirenzepine or Placebo in Type 2 Diabetic Patients (T2DM) With Painful Peripheral Neuropathy
Status: COMPLETED
Conditions: Painful Diabetic Neuropathy|Diabetes Mellitus
Interventions: DRUG: Active: WST-057 4mL (146 mg pirenzepine free base monohydrate) topical solution|DRUG: Placebo: WST-057 4mL topical solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Study Between Orally Administered Rifampicin and Vilaprisan
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: Rifampicin|DRUG: Midazolam|DRUG: BAY1002670_Vilaprisan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Bevacizumab for the Treatment Hemorrhagic Hereditary Telangiectasia (HHT) Associated With Severe Hepatic Vascular Malformations. Phase II Study
Status: COMPLETED
Conditions: Hemorrhagic Hereditary Telangiectasia
Interventions: DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 3
Status: RECRUITING
Conditions: Peripheral Vascular Diseases
Interventions: BEHAVIORAL: Muscular Strength Training Group|BEHAVIORAL: Muscular Fitness Training Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Two-week Course Versus Conventionally Fractionated Chemoradiotherapy in Rectal Cancer
Status: UNKNOWN
Conditions: Response to Toxin|Toxicity|Recurrence
Interventions: RADIATION: Two-week course of radiation|DRUG: Two-week course of radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Test Extracorporeal Photopheresis (ECP) Treatment Before/After Allogeneic Bone Marrow Transplant (BMT) or Peripheral Blood Stem Cell (PBSC) Transplant to Prevent Graft Versus Host Disease
Status: COMPLETED
Conditions: Stem Cell Leukemia of Unclear Lineage|Graft Versus Host Disease
Interventions: DRUG: extracorporeal photopheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET Imaging Study of α7 and α4β2-nAChR in Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: [18F]ASEM|DRUG: [18F]AZAN
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pomegranate Extract Biomarker Study in Osteopenic Women
Status: COMPLETED
Conditions: Osteopenic Women
Interventions: DIETARY_SUPPLEMENT: 2 POMx Capsules|DIETARY_SUPPLEMENT: 2 placebo Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate Long-term Safety, Tolerability and Efficacy of Iptacopan in Study Participants With aHUS
Status: RECRUITING
Conditions: Atypical Hemolytic Uremic Syndrome
Interventions: DRUG: Iptcaopan 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Liraglutide on Left Ventricular Function in Chronic Heart Failure Patients With and Without Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Hyperglycemia|Chronic Heart Failure
Interventions: DRUG: liraglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Gut Hormone Analogue G3215 in Adult Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus|Obesity
Interventions: DRUG: G3215|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of SyB D-0701 for Radiotherapy-Induced Nausea and Vomiting (RINV)
Status: COMPLETED
Conditions: Radiotherapy-induced Nausea and Vomiting (RINV)
Interventions: DRUG: SyB D-0701|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: A New Neuroregulatory Technology for the Therapy of AN Based on the Pathological Neural Network of ACC
Status: RECRUITING
Conditions: Feeding and Eating Disorders
Interventions: DEVICE: Deep transcranial magnetic stimulation|DEVICE: Sham deep transcranial magnetic stimulation|OTHER: Basic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Insulin Detemir Plus Insulin Aspart With Insulin NPH Plus Human Soluble Insulin in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin detemir|DRUG: insulin aspart|DRUG: insulin NPH|DRUG: human soluble insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Neural Prolotherapy for Treatment of Anserine Bursitis "NPCAB"
Status: COMPLETED
Conditions: Anserine Bursitis
Interventions: DRUG: isotonic dextrose 5% in water (D5W) solution|DRUG: corticosteroid with local anaesthetics (40 mg of triamcinolone acetonide (40 mg/ml) with 1.5 ml mepivacaine HCl 3% )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MK-8189 in Participants With Schizophrenia (MK-8189-014)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: MK-8189|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate Safety and Efficacy of a Product Named VGN-R09b in Severe AADC Deficiency
Status: NOT_YET_RECRUITING
Conditions: Aromatic L-amino Acid Decarboxylase Deficiency
Interventions: GENETIC: VGN-R09b injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Double-blind Study to Determine if Intraduodenal Indomethacin Can Decrease the Incidence of Post-ERCP Pancreatitis
Status: COMPLETED
Conditions: Pancreatitis
Interventions: DRUG: Indomethacin|DRUG: Placebo suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Drug Therapy for Pediatric Heart Failure
Status: RECRUITING
Conditions: Heart Failure Congenital
Interventions: DRUG: Captopril Tablets|DRUG: Metoprolol Oral Tablet|DRUG: Spironolactone Tablets|DRUG: Torsemide Tablets|DRUG: Potassium citrate powder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Su-Man Formula Massage Oil Acupressure on Sleep Quality and Anxiety in Patients With Insomnia
Status: COMPLETED
Conditions: Insomnia
Interventions: BEHAVIORAL: Su-Man formula massage oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: S0202 Gemcitabine and Capecitabine for Unresectable Locally Advanced Metastatic Gallbladder Cancer or Cholangiocarcinoma
Status: COMPLETED
Conditions: Extrahepatic Bile Duct Cancer|Gallbladder Cancer
Interventions: DRUG: capecitabine|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Drug Drug Interaction Clinical Trial of C1-R215 and C2-R215 in Healthy Male Volunteers
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: Treatment B|DRUG: Treatment C|DRUG: Treatment BC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypertonic Saline for Outpatient Bronchiolitis
Status: UNKNOWN
Conditions: Bronchiolitis|Respiratory Distress
Interventions: DRUG: Inhalation of salbutamol diluted in hypertonic saline|DRUG: Inhalation of salbutamol diluted in normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Immunogenicity and Safety of a Second Vaccination With the Adjuvanted Influenza Vaccine Candidate
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza Vaccine GSK1247446A|BIOLOGICAL: FluarixTM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects Of Pregabalin (Lyrica) On Sleep Maintenance In Subjects With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia|Sleep Disorders
Interventions: DRUG: Pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Two Vismodegib Regimens in Participants With Multiple Basal Cell Carcinomas
Status: COMPLETED
Conditions: Basal Cell Carcinoma
Interventions: DRUG: Vismodegib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity After COVID-19 Vaccines in Adapted Schedules
Status: COMPLETED
Conditions: Coronavirus Disease 2019|COVID-19
Interventions: DRUG: BNT162b2 30µg|DRUG: BNT162b2 20µg|DRUG: BNT162b2 6µg|DRUG: mRNA-1273 100µg|DRUG: mRNA-1273 50µg|DRUG: ChAdOx1-S [Recombinant]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Music Therapy on Upper Extremity Functions and Quality Of Life in Individuals With Cerebral Palsy
Status: RECRUITING
Conditions: Cerebral Palsy|Hemiplegic Cerebral Palsy|Music Therapy
Interventions: OTHER: Control Group|OTHER: Study (Music) Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cellular and Humoral Immunity in Elderly After Immunization With a Japanese Encephalitis Vaccine
Status: COMPLETED
Conditions: Humoral and Cellular Immune Responses
Interventions: BIOLOGICAL: IXIARO
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparing Pain After Laparoscopic Hernia Repair Using Two Different Types of Mesh Fixation
Status: UNKNOWN
Conditions: Inguinal Hernia|Pain
Interventions: DEVICE: Parietex ProGrib self-fixating mesh|DEVICE: Tack fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-blind, Active Placebo-Controlled Pilot Study of MDMA-assisted Psychotherapy in People With Chronic PTSD
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder (PTSD)
Interventions: DRUG: Active Placebo Dose MDMA (25 mg)|DRUG: Full Dose MDMA (125 mg)|DRUG: Open Label Full Dose MDMA (125 mg)|BEHAVIORAL: Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Training for Attention Deficit Hyperactivity Disorder and Developmental Delays
Status: NOT_YET_RECRUITING
Conditions: Attention Deficit Hyperactivity Disorders|Developmental Delays
Interventions: OTHER: cognitive training|OTHER: active control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardioverter DefIbriIlator PlacEMent for priMary Prevention of Sudden cArdiac Death in Patients Older Than 75 Years
Status: RECRUITING
Conditions: Heart Failure|Primary Prevention of Sudden Cardiac Death|Implantable Cardioverter Defibrillator
Interventions: DEVICE: ICD implantation|DEVICE: No ICD implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Atorvastatin as Adjunctive Treatment for Chronic Plaque Type Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Immunogenicity of a Single Dose of Merck 0657nI Staphylococcus Aureus Vaccine With or Without Merck Aluminum Adjuvant (V710-002)
Status: COMPLETED
Conditions: Staphylococcal Infections
Interventions: BIOLOGICAL: V710 (30 µg) with MAA|BIOLOGICAL: V710 (30 µg) without MAA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Varenicline and Placebo for Smoking Cessation in Schizophrenia
Status: COMPLETED
Conditions: Cigarette Smoking|Schizophrenia
Interventions: DRUG: varenicline|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study for a New Antiviral Drug to Treat Genital Herpes Type 2
Status: COMPLETED
Conditions: HSV-2
Interventions: DRUG: AIC316|DRUG: AIC316|DRUG: AIC316|DRUG: AIC316|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison the Effects of Different Neoadjuvant Chemotherapy Regimen on Acute Toxicity, Tumor Response, and Survival in Patients With Advanced Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Cisplatin|DRUG: Fluorouracil|RADIATION: Radiation therapy|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Preventive Value of Acupoint Sensitization Based on Stable Angina Pectoris
Status: COMPLETED
Conditions: The Clinical Value of Acupoint Sensitization
Interventions: PROCEDURE: Hypersensitive acupoint group|PROCEDURE: Hyposensitive acupoint group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Prevention of Recurrence of Diverticulitis
Status: COMPLETED
Conditions: Diverticulitis
Interventions: DRUG: SPD476 (1.2g)|DRUG: SPD476 (2.4 g)|DRUG: SPD476 (4.8 g)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison the Effects of Early Functional Electrical Stimulation and Transcutaneous Electrical Nerves Stimulation in Functional and Motor Recovery for Acute Stroke Patients
Status: COMPLETED
Conditions: Acute Stroke Intervention
Interventions: DEVICE: functional electrical stimulation (FES)|DEVICE: transcutaneous nerve stimulation (TENS)|OTHER: standard rehabilitation (SR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Major Depressive Disorder With Mixed Features
Status: WITHDRAWN
Conditions: Major Depressive Disorder
Interventions: DRUG: Lurasidone 20 mg|DRUG: Lurasidone 60 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ventral Abdominal Hernia Repair With Self Adhering, Atraumatic Mesh
Status: COMPLETED
Conditions: Abdominal Hernia
Interventions: DIAGNOSTIC_TEST: Selective Sonography of the ventral abdominal hernia level
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Different Cycles of Cisplatin-5-fluorouracil for the Chemoradiotherapy of Esophageal Squamous Cancer
Status: UNKNOWN
Conditions: Stage III Esophageal Squamous Cell Carcinoma|Stage II Esophageal Squamous Cell Carcinoma
Interventions: OTHER: 2 cycles cisplatin-5-fluorouracil|OTHER: 4 cycles cisplatin-5-fluorouracil|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calorie Restriction With Leucine Supplementation
Status: COMPLETED
Conditions: Obesity|Menopause|Osteoporosis|Sarcopenia
Interventions: BEHAVIORAL: Weight loss with normal protein and leucine intake|BEHAVIORAL: Weight loss with protein/leucine supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zoledronic Acid in the Prevention of Cancer Treatment Related Bone Loss in Postmenopausal Women Receiving Letrozole for Breast Cancer.
Status: COMPLETED
Conditions: Bone Loss|Breast Cancer
Interventions: DRUG: Zoledronic acid|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Assessment of Standard Half-Life (SHL) FVIII, Extended Half-Life (EHL) FVIII, and Efanesoctocog Alfa (BIVV001) in Severe Hemophilia A
Status: COMPLETED
Conditions: Hemophilia A
Interventions: DRUG: Efanesoctocog alfa|DRUG: Octocog alfa|DRUG: Rurioctocog alfa pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Frexalimab (SAR441344) in the Treatment of Systemic Lupus Erythematosus
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: SAR441344 IV|DRUG: SAR441344 SC|DRUG: Placebo IV|DRUG: Placebo SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of PTC923 in Participants With Phenylketonuria
Status: COMPLETED
Conditions: Phenylketonuria
Interventions: DRUG: PTC923|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect PEEP on Diaphragm
Status: COMPLETED
Conditions: Diaphragm Disease
Interventions: OTHER: PEEP: 5 cmH2O|OTHER: PEEP: 10 cmH2O|OTHER: PEEP: 15 cmH2O
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cardiac Allograft Vasculopathy and Dobutamine Stress Echocardiography / Brain Natriuretic Peptide Coupling
Status: COMPLETED
Conditions: Vasculopathy|Allograft
Interventions: PROCEDURE: Dobutamine stress echocardiography, coronarography, brachial arterial echography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: CS1008- in Combination With Sorafenib Compared to Sorafenib Alone in Subjects With Advanced Liver Cancer
Status: COMPLETED
Conditions: Advanced Hepatocellular Carcinoma|Liver Cancer|Hepatic Cancer|Liver Neoplasms
Interventions: DRUG: CS-1008 2 mg/kg|DRUG: Sorafenib|DRUG: CS-1008 6/2 mg/kg|DRUG: CS-1008 6/6 mg/kg|DRUG: CS-1008 4 mg/kg|DRUG: CS-1008 6 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of IV Ketamine for Emergency Department Treatment of Adolescent Suicidal Ideation
Status: NOT_YET_RECRUITING
Conditions: Suicidal Ideation
Interventions: DRUG: Ketamine Hydrochloride|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Detection of Bovine and Soy Proteins in Human Milk
Status: COMPLETED
Conditions: Microbiome|Stress|Food Allergy in Infants
Interventions: OTHER: Cow's Milk|OTHER: Soy Milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Osseointegrated Transdermal Femoral Amputation Prostheses
Status: COMPLETED
Conditions: Osseointegrated Implants|Bone Mineral Density
Interventions: DRUG: Denosumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study for the Multidimensional Analyses of Resistance and Toxicity to Immune- and Targeted-therapies.
Status: RECRUITING
Conditions: Breast Cancer|Lung Cancer|Melanoma|Head and Neck Cancer|Urothelial Carcinoma|Colorectal Cancer|Liver Metastases|Lung Metastases
Interventions: GENETIC: Cohort A: primarily operable disease, candidate to adjuvant|GENETIC: Cohort B: locally advanced disease|GENETIC: Cohort C: metastatic disease|GENETIC: Cohort D: Progressive disease|GENETIC: Cohort E: Hematological neoplasms|GENETIC: Cohort F: Toxicity
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Placebo Without Deception Versus Standard Antidepressant for Major Depressive Disorder
Status: TERMINATED
Conditions: Major Depressive Disorder
Interventions: DRUG: Duloxetine|DRUG: placebo|OTHER: Study visits only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VTE Prevention Following Total Hip and Knee Arthroplasty
Status: RECRUITING
Conditions: Venous Thromboembolism
Interventions: DRUG: Rivaroxaban 10 MG and acetylsalicylic acid 81 mg|DRUG: acetylsalicylic acid 81 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Surgical Outcomes of Conventional Hysterectomy or Manipulator-assisted Abdominal Hysterectomy
Status: ENROLLING_BY_INVITATION
Conditions: Gynecologic Disease
Interventions: PROCEDURE: Manipulator-assisted Abdominal Hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) vs. Escitalopram in Postmenopausal Women
Status: COMPLETED
Conditions: Depression|Depressive Disorder|Depressive Disorder, Major
Interventions: DRUG: Desvenlafaxine succinate sustained-release (DVS SR)|DRUG: Escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Absorbable Zinc Alloy Drug Eluting Coronary Stent System
Status: UNKNOWN
Conditions: Coronary Heart Disease|Drug Eluting Stent
Interventions: DEVICE: Absorbable zinc alloy drug eluting coronary stent system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Image-guided Proton Therapy for the Treatment of Locally Advanced Unresectable Head and Neck Cancer
Status: COMPLETED
Conditions: Locally Advanced Head and Neck Squamous Cell Carcinoma|Locally Advanced Hypopharyngeal Squamous Cell Carcinoma|Locally Advanced Laryngeal Squamous Cell Carcinoma|Locally Advanced Nasopharyngeal Squamous Cell Carcinoma|Locally Advanced Oral Cavity Squamous Cell Carcinoma|Locally Advanced Oropharyngeal Squamous Cell Carcinoma|Malignant Posterior Tongue Neoplasm|Stage II Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8|Stage II Hypopharyngeal Carcinoma AJCC v8|Stage II Laryngeal Cancer AJCC v8|Stage II Nasopharyngeal Carcinoma AJCC v8|Stage II Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8|Stage III Hypopharyngeal Carcinoma AJCC v8|Stage III Laryngeal Cancer AJCC v8|Stage III Nasopharyngeal Carcinoma AJCC v8|Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Unresectable Head and Neck Squamous Cell Carcinoma|Unresectable Oropharyngeal Squamous Cell Carcinoma
Interventions: RADIATION: Proton Beam Radiation Therapy|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blood Pressure Effects of Nebivolol Versus Lisinopril in New Onset or Worsening Hypertension Induced by Bevacizumab
Status: WITHDRAWN
Conditions: Hypertension
Interventions: DRUG: Nebivolol|DRUG: Lisinopril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Follow up Treatment of Children With Attention Deficit Hyperactivity Disorder (ADHD)
Status: UNKNOWN
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: BEHAVIORAL: Academic and Organization skills|BEHAVIORAL: Parent Training|BEHAVIORAL: Social Skills Training|DRUG: Long-acting stimulant|DRUG: Long-acting stimulant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PDE5 Inhibition for Obesity-Related Cardiometabolic Dysfunction
Status: COMPLETED
Conditions: Healthy|Obese
Interventions: DRUG: Tadalafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Metformin on Obesity and Metabolic Disturbance in Patients Taking Clozapine
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: Metformin|DRUG: Placebo (for metformin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Male Tolerance Study of Dapivirine Gel Following Multiple Topical Penile Exposures
Status: COMPLETED
Conditions: Topical Penile Exposures
Interventions: DRUG: dapivirine|DRUG: matched placebo|DRUG: universal placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: EverFlex™ Self-expanding Peripheral Stent With Entrust™ Delivery System Clinical Study
Status: COMPLETED
Conditions: Peripheral Arterial Diseases
Interventions: DEVICE: EverFlex™ stent with Entrust™ delivery system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Using the Oncogramme® Device to Select the First Line of Treatment for Patients With Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DIAGNOSTIC_TEST: Oncogramme results available|DIAGNOSTIC_TEST: Oncogramme results unavailable
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: To Evaluate the Impact of Consumption of a Bioactive Compound on Fasting Blood Glucose Levels in Asian Indians With Pre-diabetes
Status: RECRUITING
Conditions: PreDiabetes
Interventions: DIETARY_SUPPLEMENT: N-trans-caffeoyltyramine (NCT) and N-trans-feruloyltyramine (NFT)|DIETARY_SUPPLEMENT: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical and Biological Characterization of Patients and Collection of Samples
Status: UNKNOWN
Conditions: Tricho Hepato Enteric Syndrome
Interventions: BIOLOGICAL: Blood sample|OTHER: Fecal samples|BEHAVIORAL: Neuropsychological
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Cladribine in Combination With CAG in Newly Diagnosed Unfit Patients With AML
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia|Elderly Patients|Newly Diagnosed
Interventions: DRUG: Cladribine Injection|DRUG: Aclarubicin|DRUG: G-CSF|DRUG: cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nefopam for Post Video-Assisted Thoracoscopic Lobectomy
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Nefopam 20 MG/ML|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Effectiveness of Mannitol-combined Hyaluronan Supplement in the Treatment of Knee OA
Status: COMPLETED
Conditions: Knee Osteoarthritis|Hyaluronic Acid
Interventions: DEVICE: JETKNEE Synovial Fluid Supplement|DEVICE: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Of The Two Types Of Hemostasis Management Effectiveness : Thromboelastometry (Rotem) Guided Management And Conventional Method In Newborn Congenital Cardiac Surgery Patients
Status: COMPLETED
Conditions: Newborn Cardiac Surgery|Newborn Hemostasis
Interventions: OTHER: ROTEM Guided Management
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neurally Adjusted Ventilatory Assist for Neonates With Congenital Diaphragmatic Hernias
Status: ACTIVE_NOT_RECRUITING
Conditions: Congenital Diaphragmatic Hernia
Interventions: DEVICE: Neurally Adjusted Ventilatory Assist|DEVICE: Assist Control Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ReInventing Yourself After SCI: an Intervention to Improve Outcomes After Spinal Cord Injury
Status: UNKNOWN
Conditions: Spinal Cord Injuries
Interventions: BEHAVIORAL: ReInventing Yourself after SCI structured group CBT|BEHAVIORAL: ReInventing Yourself after SCI study-specific workbook|BEHAVIORAL: ReInventing Yourself after SCI YouTube videos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of SUN-131 Transdermal System (TDS) as Compared to Placebo TDS in Patients With a Chalazion
Status: COMPLETED
Conditions: Chalazion
Interventions: DRUG: SUN-131 1.5% TDS|DRUG: Placebo TDS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Levonorgestrel and Ethinyl Estradiol Tablets 15.0 mg/0.03 mg With Regards to Reference Product
Status: COMPLETED
Conditions: Therapeutic Equivalency
Interventions: DRUG: Levonorgestrel 15.0 mg and Ethinyl estradiol 0.03 mg Test Drug|DRUG: Microgynon CD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: MDR - M/L Taper With Kinectiv Technology Stems and Necks
Status: RECRUITING
Conditions: Hip Disease|Hip Fractures|Hip Injuries|Hip Arthritis|Hip Pain Chronic
Interventions: DEVICE: M/L Taper with Kinectiv Technology Stems and Necks
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: RTSS Vaccine and PBO Net Impact on Malaria Infection and Transmission in Malawi
Status: UNKNOWN
Conditions: Malaria, Malaria Vaccine, Insecticide-treated Bednets
Interventions: BIOLOGICAL: RTS,S/AS01 malaria vaccine|OTHER: PBO bed nets
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 1 Study of Topical Ocular PAN-90806 for Neovascular AMD
Status: COMPLETED
Conditions: Age-Related Macular Degeneration (AMD)
Interventions: DRUG: PAN-90806 Ophthalmic Solution|DRUG: Lucentis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD
Status: RECRUITING
Conditions: Treatment Resistant Depression
Interventions: DRUG: Psilocybin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Erenumab in Pediatric Participants With Episodic Migraine
Status: RECRUITING
Conditions: Migraine
Interventions: DRUG: Erenumab Dose 1|DRUG: Erenumab Dose 2|DRUG: Erenumab Dose 3|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cyclophosphamide Plus Topotecan in Treating Patients With Refractory or Relapsed Acute Myelogenous Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: cyclophosphamide|DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Sensory Recovery of Digital Nerves After Microsurgical Epineural Neurorrhaphy Alone or in Combination With Tisseel - RET
Status: NOT_YET_RECRUITING
Conditions: Digital Nerve Injuries
Interventions: DRUG: Tisseel®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Aclidinium Bromide/Formoterol Fumarate Compared With Salmeterol/Fluticasone Propionate in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Aclidinium Bromide / Formoterol Fumarate|DRUG: Salmeterol / Fluticasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Drug Monitoring of Risankizumab in Psoriasis Patients (BIOLOPTIM-RIS)
Status: RECRUITING
Conditions: Psoriasis Vulgaris
Interventions: PROCEDURE: Venapuncture|PROCEDURE: Patient questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of BI 1356 (Linagliptin) Versus Placebo in Type 2 Diabetic Patients With Insufficient Glycemic Control
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: linagliptin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Low-Cost High Resolution Microendoscope for the Detection of Lower Gastrointestinal Neoplasia
Status: TERMINATED
Conditions: Colon Polyps|Colonic Dysplasia|Anal Dysplasia
Interventions: DRUG: Proflavine Hemisulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Premedication With Intranasal Dexmedetomidine or Midazolam for Prevention of Emergence Agitation in Children
Status: COMPLETED
Conditions: Emergence Delirium
Interventions: DRUG: Dexmedetomidine|DRUG: Midazolam oral solution|DRUG: Oral saline|DRUG: Nasal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Case and Use Scenario Study to Gain Knowledge on the User Needs for a Medical Device for Hemophilia A Monitoring
Status: NOT_YET_RECRUITING
Conditions: Hemophilia A
Interventions: OTHER: Case scenarios - questionnaire|OTHER: Case scenarios - Focus groups|OTHER: Use scenarios - Usability test|OTHER: Use scenarios - interview
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PMCF Study of LiquiBand FIX8® OHMF Device
Status: RECRUITING
Conditions: Inguinal Hernia
Interventions: DEVICE: LiquiBand FIX8 Open Hernia Mesh Fixation Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effects of RO6889450 (Ralmitaront) in Participants With Schizophrenia or Schizoaffective Disorder and Negative Symptoms
Status: TERMINATED
Conditions: Schizophrenia, Schizoaffective Disorder
Interventions: DRUG: RO6889450|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Metronomic Chemotherapy for Locally Advanced Her2- Positive Breast Cancer (TraQ-Me 01)
Status: TERMINATED
Conditions: Locally Advanced HER2-positive Breast Cancer
Interventions: DEVICE: Drug: Paclitaxel; trastuzumab; doxorrubicin; cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Process Model of Emotion Regulation Integrated Musical Rhythm Interventions' Effects on Student Nurses' Anger
Status: COMPLETED
Conditions: Anger
Interventions: BEHAVIORAL: Gross's Process of Emotion Regulation Model Interventions|BEHAVIORAL: Musical Rhythm Interventions|BEHAVIORAL: Musical Rhythm Integrated Gross's Emotion Regulation Process Interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Zoledronic Acid in Aromatase Inhibitor Induced Musculoskeletal Symptoms
Status: COMPLETED
Conditions: Ductal Carcinoma in Situ|Estrogen Receptor-positive Breast Cancer|Progesterone Receptor-positive Breast Cancer|Stage I Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: DRUG: letrozole|DRUG: zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Tolerability and Pharmacokinetics of CMS121, a Drug Candidate for Alzheimer's Disease, in Healthy Subjects
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: CMS121|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study to Evaluate the Efficacy and Safety of a Combination Chemotherapy
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DRUG: Bortezomib 1.3 mg/m2|DRUG: Bortezomib 1.6 mg/m2|DRUG: Bortezomib 1.8 mg/m2|DRUG: Carboplatin AUC 6|DRUG: Bevacizumab|DRUG: Taxotere
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Lisinopril to Prevent Anthracycline Cardiomyopathy.
Status: WITHDRAWN
Conditions: Cardiomyopathy Due to Drug|Heart Failure, Systolic
Interventions: DRUG: Lisinopril|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Multidirectional Yoga for Cognition
Status: COMPLETED
Conditions: Standard Yoga|Multi-directional Yoga|Educational Control
Interventions: OTHER: Standard Yoga|OTHER: Multi-directional Yoga|OTHER: Educational Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Ablation of Paroxysmal Supraventricular Tachycardia Using a Novel Catheter Equipped With Mini Electrodes
Status: COMPLETED
Conditions: Paroxysmal Supraventricular Tachycardia
Interventions: DEVICE: Microfidelity (MIFI) catheter|DEVICE: Conventional ablation catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Telerehabilitation of Patients With Duchenne Muscular Dystrophy
Status: UNKNOWN
Conditions: Duchenne Muscular Dystrophy
Interventions: OTHER: Telerehabilitaton|OTHER: Home exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Spinal Cord Stimulation for Intractable Chronic Lower Abdominal Neuropathic Pain Caused by Endometriosis
Status: UNKNOWN
Conditions: Endometriosis
Interventions: DEVICE: spinal cord stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison Between Clobetasol Propionate 0.05% (Clobex®) Spray and Clobetasol Propionate 0.05% (Olux®) Foam
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Clobetasol Propionate 0.05% Spray|DRUG: Clobetasol Propionate 0.05% Foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of the Safety and Efficacy of Abatacept Injections in the Treatment of Behcet's Syndrome
Status: COMPLETED
Conditions: Female Patients With Behcet's Syndrome
Interventions: DRUG: Abatacept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Collagen Matrix With Tunnel Technique Compared to CTG for the Treatment of Periodontal Recessions
Status: COMPLETED
Conditions: Gingival Recession
Interventions: OTHER: Surgery:The tunnel technique for covering gingival recession
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Standard Treatment Associated With Phage Therapy Versus Placebo for Diabetic Foot Ulcers Infected by S. Aureus
Status: UNKNOWN
Conditions: Diabetic Foot|Staphylococcal Infections
Interventions: DRUG: Topical anti-Staphylococcus bacteriophage therapy|DRUG: Topical placebo corresponding to anti-Staphylococcus bacteriophage therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Green Banana (GB) Mixed Diet in the Management of Persistent Diarrhea (PD)
Status: UNKNOWN
Conditions: Persistent Diarrhea
Interventions: OTHER: GB mixed full strength rice suji|OTHER: Full strength rice suji Alone|OTHER: 3/4th strength rice suji
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety & Efficacy Study of BGS649 in Women With Refractory Endometriosis
Status: TERMINATED
Conditions: Pelvic Pain Associated With Refractory Endometriosis
Interventions: DRUG: BGS649|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Contribution of Brain Insulin Action for Postprandial Metabolism
Status: RECRUITING
Conditions: Glucose Metabolism Disorders
Interventions: OTHER: Oral glucose tolerance test with double-tracer dilution and intranasal insulin spray|OTHER: Oral glucose tolerance test with double-tracer dilution and intranasal placebo spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE