pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Evaluate the Safety and Efficacy of Paricalcitol Capsules in Reducing Serum Intact Parathyroid Hormone Levels in End Stage Renal Disease Subjects on Peritoneal Dialysis
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DRUG: paricalcitol capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolism, Muscle Function and Psychological Factors in Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: OTHER: Mental distress and relaxation test|OTHER: Glucose tolerance test|OTHER: Exercise test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Cognitive Rehabilitation in Older Adults With Neuron-up (CROAN)
Status: COMPLETED
Conditions: Indication for Modification of Patient Cognitive Status
Interventions: OTHER: Web platform: Neuronup
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial
Status: WITHDRAWN
Conditions: Preeclampsia|Pregnancy Induced Hypertension|Gestational Hypertension|Chronic Hypertension|Superimposed Preeclampsia
Interventions: DRUG: labetalol (seizure prevention)|DRUG: MgSO4 (seizure prevention)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Does Concomitant Use of Combined Oral Hormonal Steroids Stop Bleeding in Women Using Etonogestrel Implants (Implanon/Nexplanon®)?: A Randomized Controlled Study
Status: COMPLETED
Conditions: Uterine Hemorrhage|Contraception
Interventions: DRUG: Combined Oral Contraceptive Pill|DRUG: Placebo Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interest of Narrow Band Imaging in Detection of Upper Aerodigestive Cancers
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of Oropharynx|Squamous Cell Carcinoma of Hypopharynx|Squamous Cell Carcinoma of Larynx
Interventions: PROCEDURE: WL and NBI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: To Evaluate the Efficacy and Safety of JT-001 add-on in Paatients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin and Dapagliflozin
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: JT-001|DRUG: JT-001 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Riociguat in Scleroderma Associated Digital Ulcers
Status: COMPLETED
Conditions: Scleroderma|Digital Ulcers
Interventions: DRUG: Riociguat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Postextubation High-Flow Nasal Cannula vs Noninvasive Ventilation in Patients With Hypercapnic COPD
Status: UNKNOWN
Conditions: High-Flow Nasal Cannula|COPD
Interventions: DEVICE: High-FlowNasal Cannula|DEVICE: Noninvasive Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reversibility by Sildenafil of Exercise-Induced Abnormal Right Ventricular Pressure Response in ASD and VSD-Operated Patients
Status: UNKNOWN
Conditions: Congenital Heart Disease
Interventions: DRUG: sildenafil citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pulse Pressure Variation Based Intraoperative Fluid Management Versus Traditional Fluid Management for Colonic Cancer Patients Undergoing Mass Resection and Anastomosis
Status: COMPLETED
Conditions: Intraoperative Fluid Volume|Hemodynamics|Serum Lactate|Intestinal Edema|Length of the Hospital Stay|First Time to Gastrointestinal Motion|Postoperative Complications
Interventions: DEVICE: pulse pressure variation|OTHER: conventional fluid management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Stratafix vs. Vicryl OAGB / MGB Suture Study
Status: RECRUITING
Conditions: Morbid Obesity|Anastomotic Leak|Anastomotic Stenosis|Hemorrhage Postoperative
Interventions: DEVICE: Stratafix|DEVICE: Vicryl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AB154 Combined With AB122 for Recurrent Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: AB122|DRUG: AB154|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Cardioblate CryoFlex Surgical Ablation System in Longstanding Persistent Atrial Fibrillation
Status: TERMINATED
Conditions: Longstanding Persistent Atrial Fibrillation
Interventions: DEVICE: Cardioblate CryoFlex Surgical Ablation|PROCEDURE: Mitral Valve surgery|DEVICE: Medtronic Reveal XT Insertable Cardiac Monitor|PROCEDURE: MAZE III
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Primary Imiquimod Treatment Versus Surgery for Vulvar Intraepithelial Neoplasia
Status: COMPLETED
Conditions: Vulvar Intraepithelial Neoplasia
Interventions: DRUG: Imiquimod|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ALK29-002: A Study of Baclofen Formulations in Healthy Adults
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: Baclofen IR|DRUG: Baclofen ER
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Pregnancies of Unknown Location (PUL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Pregnancy, Ectopic|Pregnancy, High Risk|Pregnancy Early
Interventions: DIAGNOSTIC_TEST: Risk classification of PUL by M4|DIAGNOSTIC_TEST: Risk classification of PUL by NICE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Incentive-based Smoking Cessation for Methadone Patients
Status: COMPLETED
Conditions: Cigarette Smoking Among Patients Currently Receiving Methadone or Buprenorphine Treatment for Opioid Dependence
Interventions: BEHAVIORAL: incentive-based contingency management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Age-adjusted D-dimer Cutoff Levels to Rule Out Deep Vein Thrombosis: a Prospective Outcome Study
Status: UNKNOWN
Conditions: Deep Vein Thrombosis|D-dimer
Interventions: OTHER: Three-month thromboembolic risk in patient with D-dimer levels between the usual cut-off and the age-adjusted cut-off
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma
Status: RECRUITING
Conditions: Smoldering Plasma Cell Myeloma
Interventions: BIOLOGICAL: Daratumumab|DRUG: Dexamethasone|DRUG: Lenalidomide|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Excimer Laser Surgery for Anisometropic Amblyopia
Status: WITHDRAWN
Conditions: Anisometropic Amblyopia|Refractive Errors
Interventions: PROCEDURE: Photorefractive Keratectomy (PRK)|OTHER: Patching 2 hours per day|DEVICE: Excimer Laser System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Monoclonal Anti-IL6 Antibody (Tocilizumab) on the Cardiovascular Risk in Patients With Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: OTHER: Braquial ecography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Serial MRI Scans During Radiation Therapy
Status: RECRUITING
Conditions: Glioblastoma|Esophageal Cancer|Radiotherapy|Magnetic Resonance Imaging|MRI|Prostate Cancer|Vulvar Cancer|Pediatric Glioblastoma Multiforme
Interventions: DIAGNOSTIC_TEST: MRI IMAGING
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Assessment of Any Potential Retinal Effects of Tafenoquine (TQ)
Status: COMPLETED
Conditions: Malaria, Vivax
Interventions: DRUG: Tafenoquine 150 mg|DRUG: Matched placebo 150mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Advanced Glycation End-products (AGE) and the Erectile Dysfunction (DE) in Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Non-Insulin-Dependent|Erectile Dysfunction
Interventions: OTHER: DE assessment|OTHER: AGE measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: MK-5475-013 INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of MK-5475 (an Inhaled sGC Stimulator) in Adults With PH-COPD
Status: RECRUITING
Conditions: Pulmonary Hypertension|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: MK-5475|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Forehead/Glabellar Rhytide Complex With Combination Botulinum Toxin A and Hyaluronic Acid Versus Botulinum Toxin A Injection Alone
Status: COMPLETED
Conditions: Forehead/Glabellar Rhytid Complexes
Interventions: PROCEDURE: Combination Botulinum Toxin A and Hyaluronic Acid|PROCEDURE: Botulinum Toxin A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Description of Treatment Patterns and Description and Comparison of Healthcare Resource Utilization and Costs of Women With Metastatic HR+/HER2- Breast Cancer Treated With CDK4/6 Inhibitors
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Ribociclib|DRUG: Palbociclib|DRUG: Abemaciclib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Glucocorticoid in Treatment of Adult Idiopathic Nephrotic Syndrome：a Prospective Observational Study
Status: COMPLETED
Conditions: Nephrotic Syndrome，Idiopathic
Interventions: DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Providing PrEP, Hepatitis C Treatment, and MOUD Through Telemedicine at Greensboro SSP
Status: COMPLETED
Conditions: Opioid Use|Opioid Use Disorder|Risk Reduction|Hiv|Hepatitis C
Interventions: DRUG: Suboxone|DRUG: Truvada|DRUG: Mavyret
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Investigation of the Safety and Effectiveness of an Investigational Model of the TECNIS® Intraocular Lens
Status: COMPLETED
Conditions: Cataract|Corneal Astigmatism
Interventions: DEVICE: IOL Model ZFR00V|DEVICE: IOL Model ZCB00
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Education Given to Pregnancy on Prenatal Attachment, Anxiety and Fear of Birth
Status: COMPLETED
Conditions: Fear of Childbirth
Interventions: BEHAVIORAL: Birth preparation education according to travelbee human-human relations theory
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The ACTIVATE (Adoptive Cell Therapy InVigorated to Augment Tumor Eradication) Trial
Status: COMPLETED
Conditions: Advanced Ovarian Cancer|Malignant Melanoma
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|PROCEDURE: Pembrolizumab|BIOLOGICAL: Tumor-Infiltrating Lymphocytes (TILs)|BIOLOGICAL: Interleukin-2 (IL-2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab in Patients With Metastatic Renal Cell Carcinoma Who Have Progresses During or After Prior Systemic Anti-angiogenic Regimen
Status: COMPLETED
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Home Visits for Stroke Patients and Their Caregivers
Status: RECRUITING
Conditions: Stroke|Caregiver|Virtual|Home Visit
Interventions: DEVICE: Virtual Home Visit|DEVICE: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Long Term Follow-up Study in Participants Treated in a Preceding Phase 2 or 3 Study With a Regimen Containing Odalasvir and AL-335 With or Without Simeprevir for the Treatment of Hepatitis C Virus (HCV) Infection
Status: TERMINATED
Conditions: Hepatitis C
Interventions: DRUG: No Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase III Study of Comparing Paclitaxel Plus 5-Fluorouracil Versus Cisplatin Plus 5-Fluorouracil in Chemoradiotherapy for Locally Advanced Esophageal Carcinoma
Status: COMPLETED
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Paclitaxel plus 5-fluorouracil|DRUG: Cisplatin plus 5-fluorouracil|RADIATION: Radiation therapy|RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Cardiac Effects of Empagliflozin in Patients With High Risk of Heart Failure
Status: RECRUITING
Conditions: Heart Failure|Obesity
Interventions: DRUG: Empagliflozin 10 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Project PRIDE (Promoting Resilience In Discriminatory Environments)
Status: COMPLETED
Conditions: Human Immunodeficiency Virus|Sexually Transmitted Infections|Anxiety|Depression|Substance Use Disorders
Interventions: BEHAVIORAL: Project PRIDE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Addiction-Based Mobile Health Weight Loss Intervention With Coaching
Status: UNKNOWN
Conditions: Pediatric Obesity|Mobile Technology|Addiction
Interventions: BEHAVIORAL: App|BEHAVIORAL: Coaching|BEHAVIORAL: Clinic: Modified KidsNFitness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Swedish Study of Irrigation Fluid Temperature in the Evacuation of Chronic Subdural Hematoma
Status: COMPLETED
Conditions: Chronic Subdural Hematoma
Interventions: PROCEDURE: Irrigation fluid of body temperature|PROCEDURE: Irrigation fluid of room temperature
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fludeoxyglucose F 18 PET/CT Imaging in Finding Cancer in Patients Undergoing Surgery for Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: PROCEDURE: PET/CT scan|DRUG: 18F-FDG Injection|PROCEDURE: Preoperative 18F-FDG PET/CT Scan|DRUG: 18F-FDG for patients with Bladder Cancer|PROCEDURE: Surgical Procedure|PROCEDURE: Specimen PET/CT Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Toripalimab Combined With AP-induced Chemotherapy Followed in Non-metastatic IVB Hypopharyngeal Cancer
Status: RECRUITING
Conditions: Hypopharyngeal Cancer
Interventions: DRUG: Cisplatin/Nedaplatin, albumin paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Taping on Plantar Pressure Distribution in Players With Chronic Ankle Instability
Status: RECRUITING
Conditions: Ankle Injuries|Ankle Injuries and Disorders|Ankle Sprains
Interventions: OTHER: Rigid Taping|OTHER: Kinesio-Taping|OTHER: Sham Taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Body Perception and Representation in Overgrowth Syndromes, Behavioral Assessment and Neuropsychological Development
Status: RECRUITING
Conditions: Sotos Syndrome|Beckwith-Wiedemann Syndrome|Overgrowth Syndrome|Body Image|Body Schema
Interventions: BEHAVIORAL: NEPSY-II|BEHAVIORAL: CBCL and AQ questionnaires|BEHAVIORAL: BUT questionnaire and experimental tasks
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Investigate Safety, Tolerability and Effect of Multiple Dosing With AZD 4721 and/or With AZD 5069
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD).
Interventions: DRUG: AZD4721|DRUG: Placebo|DRUG: AZD5069
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Therapeutic Efficacy Between Intralesional Bleomycin and Cryotherapy in Plantar Warts
Status: COMPLETED
Conditions: Viral Wart
Interventions: PROCEDURE: COMPARISON OF THERAPEUTIC EFFICACY BETWEEN INTRALESIONAL BLEOMYCIN AND CRYOTHERAPY IN PLANTAR WARTS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Drug Interaction Study to Assess the Effect of LY317615 on the Metabolic Pathway of Warfarin
Status: COMPLETED
Conditions: Solid Tumor|Lymphoma, Malignant
Interventions: DRUG: warfarin|DRUG: enzastaurin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Radioablation With or Without Androgen DeprIvation Therapy in Metachronous Prostate Cancer OligometaStAsis
Status: RECRUITING
Conditions: Oligometastatic Prostate Cancer
Interventions: DRUG: Androgen deprivation therapy (ADT)|RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quetiapine Augmentation in Severe Obsessive Compulsive Disorder
Status: COMPLETED
Conditions: Obsessive Compulsive Disorder
Interventions: DRUG: quetiapine fumarate|DRUG: SSRI/Clomipramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate a Research Drug as an Aid for Smoking Cessation in Chronic Cigarette Smokers (0364-007)
Status: COMPLETED
Conditions: Smoking
Interventions: DRUG: taranabant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Montelukast on Smokers With Asthma
Status: COMPLETED
Conditions: Asthmatic Smokers|Non-asthmatic Smokers
Interventions: DRUG: Fluticasone Propionate|DRUG: Montelukast|DRUG: Salmeterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Dasatinib for the Treatment of Moderate and Severe COVID-19
Status: WITHDRAWN
Conditions: Symptomatic COVID-19 Infection Laboratory-Confirmed
Interventions: DRUG: Dasatinib Anhydrous|DRUG: Placebo Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Pharmacolkinetics of Aldoxorubicin (INNO-206;DOXO-EMCH) Administered as a 30 Minute Infusion Every 3 Weeks in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: aldoxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Toremifene Followed by Radical Prostatectomy in Treating Patients With Stage I or Stage II Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: toremifene|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ringer Lactate Preloading on Induction Dose Requirement of Propofol
Status: RECRUITING
Conditions: Anesthesia|Ringer's Lactate
Interventions: DRUG: Ringer Lactate prior to surgery and Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety Study of BF2.649 and BF2.649 Add on Modafinil on Cataplexy in Patients With Narcolespy
Status: COMPLETED
Conditions: Narcolepsy|Cataplexy|Excessive Daytime Sleepiness
Interventions: DRUG: BF2.649|DRUG: BF2.649 add on Modafinil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Prone Positioning on the Severity of COVID-19 Pneumonia and Acute Respiratory Distress Syndrome.
Status: COMPLETED
Conditions: COVID-19 Acute Respiratory Distress Syndrome|COVID-19 Pneumonia|Prone Positioning
Interventions: OTHER: Prone Positioning Maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diaphragm Paralysis: Surgery or Mechanical Ventialion
Status: RECRUITING
Conditions: Diaphragm Paralysis
Interventions: OTHER: surgical plication" or "nocturnal non-invasive ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Susceptibility to Infections in Ataxia Telangiectasia
Status: COMPLETED
Conditions: Ataxia Telangiectasia|Infections|Immunodeficiency|Lung Disease
Interventions: PROCEDURE: Blood collection|PROCEDURE: Lung function measurement|BEHAVIORAL: Symptom diary
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Red Raspberries on Insulin Action and Oxidative Stress
Status: COMPLETED
Conditions: Insulin Resistant
Interventions: DIETARY_SUPPLEMENT: Red raspberry meal 1|DIETARY_SUPPLEMENT: Red raspberry meal 2|DIETARY_SUPPLEMENT: Control meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: DESVELA. Personal Skills as Determinants of Morbidity, Lifestyles, Quality of Life, Use of Services and Mortality.
Status: ACTIVE_NOT_RECRUITING
Conditions: General Population|Health Knowledge, Attitudes, Practice|Empowerment|Health Care Utilization|Life Style|Self Efficacy|Activation, Patient|Locus of Control|Quality of Life
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Aerobic Exercise in Patients With Lacunar Stroke
Status: UNKNOWN
Conditions: Stroke, Lacunar
Interventions: OTHER: High-intensity training|DRUG: prophylactic stroke medication|BEHAVIORAL: Recommendations for lifestyle changes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tracking Inflammatory Cells Using Superparamagnetic Particles of Iron Oxide (SPIO) and Magnetic Resonance Imaging (MRI)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Administration of intra-dermal Endorem|BIOLOGICAL: Mantoux test|BIOLOGICAL: Autologous Endorem-labelled mononuclear cells|DRUG: Administration of Endorem
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Utility of Biparametric MRI (Magnetic Resonance Imaging) as a Screening Tool for Prostate Cancer in a High-Risk Cohort
Status: RECRUITING
Conditions: Prostate Cancer|Magnetic Resonance Imaging|Population at Risk
Interventions: DIAGNOSTIC_TEST: Bi-parametric MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study to Evaluate the Efficacy and Safety of Shenfu Zhusheye in Patients With Acute Heart Failure
Status: COMPLETED
Conditions: Acute Heart Failure
Interventions: DRUG: Shenfu Zhusheye|DRUG: 5% glucose injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety Study of Alogliptin Used in Combination With Sulfonylurea or Metformin in Participants With Type 2 Diabetes in Japan
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Alogliptin and glimepiride|DRUG: Alogliptin and glimepiride|DRUG: Alogliptin and metformin|DRUG: Alogliptin and metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Family-Focused Adolescent & Lifelong Health Promotion
Status: COMPLETED
Conditions: Adolescent Behavior|Adolescent - Emotional Problem|Psychological Well-Being|Parent-Child Relations|Parenting
Interventions: BEHAVIORAL: Parenting for Lifelong Health for Parents and Teens
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study for the Prevention of Nausea and Vomiting in Multiple Myeloma Patients Receiving Stem Cell Transplantation.
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Palonosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pectoral-Intercostal Fascial Plane Block Study
Status: COMPLETED
Conditions: Anesthesia, Regional|Pain, Postoperative
Interventions: PROCEDURE: Pectoral-intercostal fascial plane block (PIFB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritive Effects of Prebiotics on Early Postnatal Behavioral Measures of Tolerance
Status: COMPLETED
Conditions: Behavioral Measures of Tolerance
Interventions: OTHER: Previously marketed cow's mlik-based infant formula|OTHER: Marketed cow's milk-based infant formula with prebiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Depersonalization Disorder: Therapeutic Effect of Neuronavigated Repetitive Transcranial Stimulation
Status: COMPLETED
Conditions: Depersonalization Disorder
Interventions: DEVICE: Active rTMS|DEVICE: Placebo rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Platelet Rich Plasma Therapy for Acute Ankle Sprains in the Emergency Department
Status: COMPLETED
Conditions: Sprain of Ankle
Interventions: PROCEDURE: Platelet rich plasma injection|PROCEDURE: Placebo Comparator: Placebo/Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Enhanced Room Cleaning in Intensive Care Units to Reduce Gown and Glove Contamination With Multi-drug-resistant Bacteria
Status: COMPLETED
Conditions: Infection Control
Interventions: OTHER: Enhanced cleaning of surfaces in ICU rooms|OTHER: Sham enhanced cleaning of surfaces in ICU rooms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Evaluation of the Ulthera™ System for Obtaining Lift and Tightening of the Cheek Tissue
Status: COMPLETED
Conditions: Mild to Moderate Skin Laxity on Cheek|Mild to Moderate Skin Laxity on Upper Neck|Mild to Moderate Subcutaneous Fat on Cheek|Mild to Moderate Subcutaneous Fat on Upper Neck
Interventions: DEVICE: Ulthera treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GSK1349572 Drug Interaction Study With Atazanavir/Ritonavir and Atazanavir
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: GSK1349572|DRUG: Atazanavir 300 mg|DRUG: Atazanavir 400 mg|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Investigation of Mortality, Morbidity and Risk Factors After Pediatric Liver Transplantation
Status: COMPLETED
Conditions: Liver Transplantation|Liver Diseases|Biliary Atresia|Morbidity;Infant|Mortality
Interventions: PROCEDURE: Liver Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Pilot Study for the Evaluation of Endoscopic Sleeve Gastroplasty With Endomina® for the Treatment of Obesity in Liver Transplant Candidates
Status: RECRUITING
Conditions: Liver Transplantation|Obesity|Bariatric Surgery
Interventions: PROCEDURE: Endoscopic sleeve gastroplasty (ESG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of ASP1707 in Postmenopausal Female Patients With Rheumatoid Arthritis Taking Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: ASP1707|DRUG: Placebo|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Midostaurin in Treating Older Patients With Mutated Acute Myeloid Leukemia Post-Transplant
Status: WITHDRAWN
Conditions: Acute Myeloid Leukemia With Gene Mutations|Adult Acute Myeloid Leukemia in Remission
Interventions: DRUG: Midostaurin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fast Exome for Diagnosis of Congenital Conditions in Infants Under 12 Months of Age Hospitalized in Intensive Care Unit
Status: COMPLETED
Conditions: Infant, Newborn, Diseases|Congenital Malformations|Intensive Care Unit|Neurologic Symptoms
Interventions: OTHER: Genetic analyse by whole exome sequencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Limited to Skin, Eyes, and Mouth
Status: COMPLETED
Conditions: Herpes Simplex
Interventions: DRUG: acyclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of AG10 in Subjects With Transthyretin Amyloid Cardiomyopathy
Status: COMPLETED
Conditions: Amyloidosis|Amyloid Cardiomyopathy|Transthyretin Amyloidosis|Cardiomyopathies|Heart Diseases
Interventions: DRUG: acoramidis|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of the Safety and Efficacy of Single-Dose Administration of ANB-010 in Subjects With Hemophilia A
Status: RECRUITING
Conditions: Hemophilia A
Interventions: GENETIC: ANB-010, dose 1|GENETIC: ANB-010, dose 2|GENETIC: ANB-010, dose 3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Handheld-multimedia Versus Oral Midazolam in Pediatric on Perioperative Anxiety
Status: UNKNOWN
Conditions: Perioperative Anxiety|Preanesthetic Medication|Inhalation Anesthesia|Ambulatory Surgery|Tonsillectomy|Circumcision|Dental Care
Interventions: DRUG: Midazolam oral solution|DEVICE: IPAD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Comparison of Two Resin Composites on Diastema Closure and Reshaping at Four Years
Status: COMPLETED
Conditions: Diastema
Interventions: OTHER: Charisma-Diamond|OTHER: Filtek-Z550
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of SMART101 in Adult Patients With Hematological Malignancies After Haploidentical HSCT With Post-transplant Cyclophosphamide
Status: RECRUITING
Conditions: Hematological Malignancies
Interventions: BIOLOGICAL: Allogeneic T cell progenitors, cultured ex-vivo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GnRHa + Letrozole in Non-obese Progestin-insensitive Endometrial Cancer and Atypical Hyperplasia Patients
Status: RECRUITING
Conditions: Endometrial Neoplasms|Atypical Endometrial Hyperplasia|Progesterone Resistance
Interventions: DRUG: GnRHa|DRUG: Letrozole 2.5mg|DRUG: Diane-35|DRUG: MET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Oral Doses of Clindamycin in Preventing Post-operative Sequelae of Lower Third Molar Surgery
Status: UNKNOWN
Conditions: Impacted Third Molar Tooth|Impacted Molar
Interventions: DRUG: Dalacin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of Indenoisoquinolines LMP400 and LMP776 in Adults With Relapsed Solid Tumors and Lymphomas
Status: COMPLETED
Conditions: Neoplasms|Lymphoma
Interventions: DRUG: LMP400|DRUG: LMP776
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Intradermal Injections of RCS-01 in Male and Female Subjects
Status: COMPLETED
Conditions: Intrinsic Aging of Skin|Skin Wrinkling|Solar Degeneration of Skin
Interventions: DRUG: RCS-01|DRUG: Placebo|DEVICE: Sham injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Japanese Study Evaluating Safety, Efficacy and Acceptability of Telithromycin in Children With Infections
Status: COMPLETED
Conditions: Infections|Child
Interventions: DRUG: telithromycin (HMR3647)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Anti-inflammatory Cytokines and Antimicrobial Peptide LL-37 Biomarkers in the Treatment of Periodontal Disease.
Status: COMPLETED
Conditions: Periodontal Diseases|Periodontitis
Interventions: DIAGNOSTIC_TEST: Crevicular fluid analysis by using ELISA testing.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial of 3D Telemedicine
Status: UNKNOWN
Conditions: Telemedicine|Surgery
Interventions: OTHER: 3D Telemedicine|OTHER: 2D Telemedicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The VA HDL Intervention Trial (HIT): Secondary Prevention of Coronary Heart Disease in Men With Low HDL-Cholesterol and Desirable LDL-Cholesterol
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DRUG: gemfibrozil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Tetracaine/Oxymetazoline Nasal Spray for Endodontic Treatment
Status: WITHDRAWN
Conditions: Endodontic Disease|Endodontic Inflammation|Local Anesthesia|Dental Anesthesia
Interventions: DRUG: Tetracaine HCl and oxymetazoline HCl nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RTA 408 Capsules in Patients With Friedreich's Ataxia - MOXIe
Status: ACTIVE_NOT_RECRUITING
Conditions: Friedreich Ataxia
Interventions: DRUG: Omaveloxolone Capsules, 2.5 mg|DRUG: Omaveloxolone Capsules, 5 mg|DRUG: Omaveloxolone Capsules, 10 mg|DRUG: Placebo|DRUG: Omaveloxolone Capsules, 20 mg|DRUG: Omaveloxolone Capsules, 40 mg|DRUG: Omaveloxolone Capsules, 80 mg|DRUG: Omaveloxolone Capsules, 160 mg|DRUG: Omaveloxolone Capsules, 300 mg|DRUG: Omaveloxolone Capsules, 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Video-stylet for Nasotracheal Intubation in Limited Mouth Opening Patient
Status: UNKNOWN
Conditions: Anesthesia Intubation Complication
Interventions: DEVICE: video-stylet|DEVICE: fiberoptic bronchoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First-in-human Study Evaluating Romosozumab (AMG 785) in Healthy Men and Postmenopausal Women
Status: COMPLETED
Conditions: Osteopenia
Interventions: DRUG: Romosozumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of K-808 (Pemafibrate) in Participants with Primary Biliary Cholangitis (PBC) with Inadequate Response to Ursodeoxycholic Acid (UDCA) And/or Obeticholic Acid (OCA) Treatment.
Status: RECRUITING
Conditions: Primary Biliary Cholangitis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-dose Capecitabine Adjuvant Chemotherapy for Elderly Patients With Stage II/III Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Neoplasms
Interventions: DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of XL820 in Adults With Advanced GIST Resistant to Imatinib and/or Sunitinib
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumors|Gastrointestinal Neoplasms
Interventions: DRUG: XL820|DRUG: XL820
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study to Assess an Escalating Dose, Multi-prime Vaccination Schedule of R21/Matrix-M™
Status: RECRUITING
Conditions: Malaria,Falciparum
Interventions: BIOLOGICAL: R21/Matrix M™ (Group 1)|BIOLOGICAL: R21/Matrix M™ (Group 2)|BIOLOGICAL: R21/Matrix M™ (Group 3)|PROCEDURE: Fine needle aspiration (FNA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Broadly Neutralizing Antibodies Combined With Therapeutic Vaccination for the Induction of HIV Remission
Status: NOT_YET_RECRUITING
Conditions: HIV Infections|PLWH|ART|Acute HIV Infection
Interventions: BIOLOGICAL: VRC07-523LS|BIOLOGICAL: PGDM1400LS|BIOLOGICAL: ChAdOx1.tHIVconsv1|BIOLOGICAL: ChAdOx1.HIVconsv62|BIOLOGICAL: MVA.tHIVconsv4|BIOLOGICAL: A244d11 gp120|BIOLOGICAL: ALFQ|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: High-Dose Corticosteroid or Tocilizumab for Clinical Worsening of COVID-19
Status: WITHDRAWN
Conditions: COVID-19 Virus Infection|Cytokine Storm|Corticosteroid|Tocilizumab
Interventions: DRUG: Methylprednisolone|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Response to NonInvasive Mechanical Ventilation According to the Breathing Pattern
Status: WITHDRAWN
Conditions: Neuromuscular Disorders|Chest Wall Disorders|Obesity Hypoventilation Syndrome (OHS)
Interventions: DEVICE: Spontaneous Ventilation Mode|DEVICE: Controlled Ventilation Mode|DEVICE: Simulator Ventilation Mode
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: |Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: MICHL-trial: Impact of Peritoneal Bladder Flap in RARP Patients on Lymphoceles
Status: COMPLETED
Conditions: Lymphocele After Surgical Procedure
Interventions: OTHER: Michl-stitch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Decision Aid for Chemotherapy in Cisplatin-Intolerant Patients With Locally Advanced Cervical Cancer
Status: RECRUITING
Conditions: Locally Advanced Cervical Carcinoma
Interventions: BEHAVIORAL: CECIL Patient Decision Aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of Carboplatin-Paclitaxel/Nab-Paclitaxel Chemotherapy With or Without Pembrolizumab (MK-3475) in Adults With First Line Metastatic Squamous Non-small Cell Lung Cancer (MK-3475-407/KEYNOTE-407)
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Paclitaxel|DRUG: Nab-paclitaxel|DRUG: Carboplatin|DRUG: Saline placebo for pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interleukin-15 (IL-5) in Combination With Avelumab (Bavencio) in Relapsed/Refractory Mature T-cell Malignancies
Status: COMPLETED
Conditions: Peripheral T-cell Lymphoma NOS|Mycosis Fungoides|Sezary Syndrome|Anaplastic Large Cell Lymphoma
Interventions: DRUG: rhIL-15|DRUG: rhIL-15|BIOLOGICAL: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Clinical Study of QLC1101 in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer|Colorectal Cancer|Pancreatic Cancer|Solid Tumor
Interventions: DRUG: QLC1101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endostar and/or Cisplatin for Treatment of Malignant Pleural Effusion or Ascites
Status: COMPLETED
Conditions: Malignant Pleural Effusion|Malignant Ascites
Interventions: DRUG: Endostar|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing New Educational Materials About Genetic Testing for a Diverse Group of Cancer Patients
Status: RECRUITING
Conditions: Educational Materials for Genetic Testing|Breast Cancer|Ovarian Cancer|Prostate Cancer|Pancreatic Cancer
Interventions: OTHER: Cognitive interview
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: CHOP vs GEM-P in 1st Line Treatment of T-cell Lymphoma, Multicentre Phase II Study
Status: UNKNOWN
Conditions: Peripheral T-cell Lymphoma NOS|Anaplastic Large Cell Lymphoma, ALK-Negative|Angioimmunoblastic T-cell Lymphoma|Hepatosplenic Gamma/ Delta T-cell Lymphoma|Enteropathy-Associated T-Cell Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Gemcitabine|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisolone|DRUG: methylprednisolone|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible Smokers
Status: UNKNOWN
Conditions: Copd|Smoking|Tobacco Use
Interventions: PROCEDURE: Bronchoscopy with Bronchoalveolar Lavage (BAL)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Tolerability and Pharmacokinetics of Increasing Doses of BIBN 4096 BS in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIBN 4096 BS - in single rising doses|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT