pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase 2 Study for the Treatment of Superficial Lipomas
Status: COMPLETED
Conditions: Lipoma
Interventions: DRUG: Deoxycholic Acid Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease
Status: UNKNOWN
Conditions: Graves Ophthalmopathy
Interventions: RADIATION: External beam radiotherapy|DRUG: intravenous corticosteroids (methylprednisolone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Response of Metabolic Syndrome and Sexual Dysfunction to Lifestyle Changes in Men With Psoriasis
Status: RECRUITING
Conditions: Psoriasis|Metabolic Syndrome|Erectile Dysfunction
Interventions: BEHAVIORAL: lifestyle modification (exercise and control of diet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Yuflyma® (Adalimumab), Patient Experience After Switching
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Ankylosing Spondylarthritis|Axial Spondyloarthritis Without Radiographic Evidence of Ankylosing Spondylitis|Psoriatic Arthritis|Crohn Disease|Ulcerative Colitis
Interventions: DRUG: Adalimumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Cryotherapy Versus 5-Fluorouracil in the Treatment of Actinic Keratosis
Status: ENROLLING_BY_INVITATION
Conditions: Actinic Keratoses
Interventions: PROCEDURE: Cryotherapy|DRUG: 5Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concussion Assessments in Football
Status: ENROLLING_BY_INVITATION
Conditions: Cerebral Concussion|Brain Concussion|Post-Concussion Symptoms|TBI (Traumatic Brain Injury)
Interventions: DIAGNOSTIC_TEST: The Sport Concussion Assessment Tool 5th Edition (SCAT5)|DIAGNOSTIC_TEST: The Immediate Post-Concussion Assessment and Cognitive Testing tool version 4 (ImPACT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Binimetinib and Encorafenib for the Treatment of Advanced Solid Tumors With Non-V600E BRAF Mutations
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: Binimetinib|DRUG: Encorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liver Resection and Floxuridine Plus Fluorouracil and Leucovorin in Treating Patients With Liver Metastases From Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Metastatic Cancer
Interventions: DRUG: floxuridine|DRUG: fluorouracil|DRUG: leucovorin calcium|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Angeliq and Prempro on Blood Pressure and Sodium Sensitivity in Postmenopausal Women With Prehypertension
Status: COMPLETED
Conditions: Postmenopause|Hypertension|Pre-Hypertension
Interventions: DRUG: Drospirenone/17ß-estradiol (Angeliq, BAY86-4891)|DRUG: Drospirenone/17ß-estradiol (Angeliq, BAY86-4891)|DRUG: SH K 00641 C - Medroxyprogesterone acetate / conjugated equine (Prempro TM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Antiseptic Mouth Rinses to Reduce Salivary Viral Load in COVID-19 Patients
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Betadine© bucal 100 mg/ml|DRUG: Oximen® 3%|DRUG: Clorhexidine Dental PHB©|DRUG: Vitis Xtra Forte©|DRUG: Distilled Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Green Tea Polyphenol in De Novo Parkinson's Disease Patients
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Green Tea Polyphenols (EGCG/ECG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Sequences of Aerobic and Resistance Exercise and Cardio-metabolic Functions in T2D
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: AR group: aerobic training before resistance training|BEHAVIORAL: RA group: resistance exercise before aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First-time-in-human Study of BGB149
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: BGB149|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Camrelizumab With Apatinib as Neoadjuvant Therapy for Participants With Resectable Non-Small Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: NSCLC
Interventions: DRUG: SHR-1210|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CTX-009 in Adult Patients With Metastatic Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Colorectal Cancer|Colon Cancer|Rectal Cancer
Interventions: DRUG: CTX-009
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of OMP-336B11 in Subjects With Locally Advanced or Metastatic Tumors
Status: TERMINATED
Conditions: Locally Advanced Malignant Neoplasm|Metastatic Cancer
Interventions: DRUG: OMP-336B11
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Auditory Rehabilitation and Cognition in Alzheimer Patients
Status: COMPLETED
Conditions: Alzheimer's Disease|Hearing Loss
Interventions: DEVICE: Hearing aids|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reversing Tissue Fibrosis to Improve Immune Reconstitution in HIV
Status: COMPLETED
Conditions: HIV Infection|HIV Infections
Interventions: DRUG: Losartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Thorough ECG (Electrocardiogram) and Drug Interaction Study With Anetumab Ravtansine and Itraconazole
Status: COMPLETED
Conditions: Medical Oncology
Interventions: DRUG: Anetumab ravtansine (BAY94-9343)|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Protocol for Rosiglitazone Versus Gliclazide in Diabetics With Angina
Status: WITHDRAWN
Conditions: Angina Pectoris|Diabetes Mellitus, Type 2
Interventions: DRUG: Rosiglitazone|DRUG: Gliclazide (Comparison drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Impact of Myfortic on Gastrointestinal (GI) Prophylaxis in Maintenance Renal Transplant Patients
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: GI medication
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Susceptibility to High Altitude Pulmonary Edema in Subjects With Increased Hypoxic Pulmonary Vasoconstriction
Status: COMPLETED
Conditions: High Altitude Pulmonary Edema
Interventions: OTHER: Altitude Exposure:
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Prospective Randomized Phase II Study Evaluating the Monitoring of Imatinib Mesylate Plasmatic Through Level in Patients Newly Diagnosed With CP-CML
Status: COMPLETED
Conditions: Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Interventions: DRUG: Posology dose modification|OTHER: active comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Superiority of On-demand PrEP Versus PEP on Using Doxycycline for Preventing STI in MSM
Status: NOT_YET_RECRUITING
Conditions: Sexually Transmitted Diseases, Bacterial|Syphilis|Gonorrhea|Chlamydia
Interventions: DRUG: DoxyODPrEP|DRUG: DoxyPEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Determining the Effect of Antibiotic Drop Prophylaxis on the Conjunctival Flora
Status: COMPLETED
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: Moxifloxacin 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Tuberculosis - Learning the Impact of Nutrition
Status: ACTIVE_NOT_RECRUITING
Conditions: Tuberculosis|Malnutrition|Helminth Infection
Interventions: DIETARY_SUPPLEMENT: Nutritional Supplementation Meal|DIETARY_SUPPLEMENT: Multivitamin|DRUG: Anti-parasitic medications
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multimodal Therapy for the Treatment of Fatigue in Patients With Prostate Cancer Receiving Radiotherapy With Androgen Deprivation Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: OTHER: Placebo|DRUG: Methylphenidate|BEHAVIORAL: Counseling Sessions|OTHER: Sham Exercise|OTHER: Standardized Exercise Intervention Program|OTHER: Cognitive Behavioral Therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Human Anti-TNF Monoclonal Antibody Adalimumab in Children With Polyarticular Juvenile Idiopathic Arthritis (JIA)
Status: COMPLETED
Conditions: Arthritis, Juvenile Idiopathic
Interventions: BIOLOGICAL: Double-Blind Adalimumab/Placebo + MTX|BIOLOGICAL: Double-Blind Adalimumab/Placebo|DRUG: OLE BSA Adalimumab +/- MTX|DRUG: OLE FD Adalimumab +/- MTX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Educational Strategy on a Vulnerable Population to Improve Cardiovascular Health and Food Insecurity
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Health|Food Insecurity|Healthy Lifestyle|Vulnerable Population
Interventions: OTHER: Education on a healthy lifestyle and health literacy|OTHER: Education on a healthy lifestyle and health literacy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Neuraxial Preservative Free Morphine for Normal Spontaneous Vaginal Delivery
Status: COMPLETED
Conditions: Postpartum Pain|Postpartum Depression|Opioid Consumption
Interventions: DRUG: Preservative Free Morphine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Liposomal Doxorubicin (Doxil) and Weekly Docetaxel (Taxotere)
Status: COMPLETED
Conditions: Cancer|Carcinoma
Interventions: DRUG: liposomal doxorubicin and docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Swiss Pediatric Inflammatory Brain Disease Registry (Swiss-Ped-IBrainD)
Status: RECRUITING
Conditions: Optic Neuritis|Transverse Myelitis|Acute Disseminated Encephalomyelitis|Multiple Sclerosis|Neuromyelitis Optica Spectrum Disorder|Anti-NMDAR Encephalitis|Anti-GAD65 Associated Autoimmune Encephalitis|Anti-AMPAR-1/2 Associated Autoimmune Encephalitis|Anti-Lgi-1 Associated Autoimmune Encephalitis|Anti-CASPR-2 Associated Autoimmune Encephalitis|Anti-GABAR-1/2 Associated Autoimmune Encephalitis|Onconeuronal Antibody (Hu, Ri, Yo, Amphiphysin, CRMP-5, Ma-1, Ma-2, SOX-1) Associated Autoimmune Encephalitis|Hashimoto Encephalitis|CNS Vasculitis|CNS Sarcoidosis|CNS Lupus|Rasmussen Encephalitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Folic Acid Supplementation in Pregnant Women: Dose Response
Status: COMPLETED
Conditions: Pregnancy
Interventions: DIETARY_SUPPLEMENT: Folic acid, 400 mcg/day|DIETARY_SUPPLEMENT: Folic acid 800 mcg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Study on 5-aminolevulinic Acid Hydrochloride (5-ALA) for Fluorescence-guided Resection of Malignant Gliomas
Status: COMPLETED
Conditions: Brain Neoplasm
Interventions: BIOLOGICAL: Gliolan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: A PK/PD Study of Fospropofol Disodium Compared With Propofol Injectable Emulsion
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Fospropofol disodium, propofol|DRUG: Fospropofol disodium, propofol|DRUG: Fospropofol disodium, propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Pharmacokinetics of XMAB24306 in Combination With Daratumumab in Participants With Relapsed/Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: XmAb24306|DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Natural Antioxidants in the Treatment of Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Ginkgo biloba|DRUG: Alpha-lipoic acid|DRUG: Vitamin E/Selenium|DRUG: Essential fatty acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Identification and Evaluation of Endogenous Markers for the Assessment of CYP3A Activity
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Midazolam|DRUG: Ketoconazole|DRUG: Rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Electrical Stimulation With and Without Constraint Induced Movement Therapy in Erb's Palsy
Status: COMPLETED
Conditions: Erb's Palsy
Interventions: OTHER: EMS with CIMT|OTHER: EMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biorhythms in Metabolic Tissues
Status: UNKNOWN
Conditions: Sleep Deprivation|Metabolic Disturbance|Biological Clocks|Healthy
Interventions: OTHER: Low-fat dietary intervention|OTHER: High-fat dietary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Indocyanine Angiographic Changes of Choroidal Neovascularization by Ranibizumab
Status: COMPLETED
Conditions: Exudative Age-related Macular Degeneration
Interventions: DRUG: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Daily Everolimus in Combination With Trastuzumab and Vinorelbine in HER2/Neu Positive Women With Locally Advanced or Metastatic Breast Cancer
Status: COMPLETED
Conditions: HER2/Neu Over-expressing Locally Advanced Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: everolimus|DRUG: Placebo|DRUG: vinorelbine|DRUG: trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chemokine Receptor CXCR4-targeting Molecular Imaging for Metabolic Characterization of Multiple Myeloma and Lymphoma
Status: UNKNOWN
Conditions: Multiple Myeloma|Lymphoma
Interventions: DRUG: 68Ga-Pentixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Alogliptin Combined With Metformin in Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Alogliptin and metformin|DRUG: Alogliptin and metformin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fluorouracil and Biological Therapy in Treating Patients With Metastatic Kidney or Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer|Kidney Cancer
Interventions: BIOLOGICAL: lymphokine-activated killer cells|BIOLOGICAL: recombinant interferon alfa|BIOLOGICAL: sargramostim|DRUG: fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Robot-Mediated Intervention for Children With Autism Spectrum Disorders
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Robot-mediated Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Uterine Transplantation From Living Donors in Terms of Efficacy and Safety in Patients With Mayer-Rokitansky-Küster-Hauser Syndrome (MRKH)
Status: RECRUITING
Conditions: Mayer Rokitansky Kuster Hauser Syndrome
Interventions: PROCEDURE: Uterine transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Compare The Efficacy And Safety Of Pegvisomant To That Of Sandostatin Lar Depot In Patients With Acromegaly
Status: COMPLETED
Conditions: Acromegaly
Interventions: DRUG: Pegvisomant|DRUG: Sandostatin LAR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-inflammatory Dietary Intervention in Overweight and Obese Adolescents
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: DIETARY_SUPPLEMENT: Supplement containing fish oil, vitamin C, alpha-tocopherol, green tea extract and lycopene|DIETARY_SUPPLEMENT: Placebo supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Arm Study Treating Patients of Peritoneal Surface Malignancy (Colorectal, Appendical, Pseudomyxoma, Gastric) With Cytoreductive Surgery and Hyperthermic Intraperitoneal Mitomycin-C
Status: COMPLETED
Conditions: Peritoneal Carcinomatosis|Colorectal Cancer|Appendiceal Cancer|Peritoneal Mesothelioma|Pseudomyxoma Peritonei|Gastric Cancer
Interventions: PROCEDURE: HIPEC|DRUG: Mitomycin C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Dose Pharmacokinetics (PK) Study of GSK2434735 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Intravenous (IV) single dose|DRUG: Subcutaneous (SC) single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intranasal Dexmedetomidine vs. Standard of Care for Emergency Department (ED) Procedural Sedation in the Older Adult
Status: NOT_YET_RECRUITING
Conditions: Altered Mental Status
Interventions: DRUG: Dexmedetomidine|DRUG: Lorazepam|DRUG: Haloperidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tirapazamine Combined With Chemo and RT in Limited-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Limited Stage Small Cell Lung Cancer
Interventions: DRUG: tirapazamine|DRUG: cisplatin|DRUG: etoposide|RADIATION: radiation therapy|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Discontinuation of Orthokeratology on Eyeball Elongation in Myopic Children
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: ortho-k lenses|DEVICE: single-vision glasses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Posterior Minimally Invasive Plate Osteosynthesis (MIPO) for Humerus Diaphyseal Fractures
Status: UNKNOWN
Conditions: Humerus Fracture
Interventions: PROCEDURE: MIPO with Extra-articular Distal Humeral Anatomical Plate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immediate and 24-hour Effects of HyperVolt, Body Tempering, and Cupping Compared to Stretching on Hamstring Flexibility
Status: RECRUITING
Conditions: Hamstring Contractures|Muscle Tightness
Interventions: DEVICE: Hypervolt|DEVICE: Body Tempering|DEVICE: Dry cupping|OTHER: Static stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of Perindopril and Zofenopril on Blood Pressure Control and Oxidative Status Blacks Hypertensive Patients.
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Perindopril Arginine|DRUG: Zofenopril, Calcium Salt, (1(R*),2Alpha,4Alpha)-isomer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Kinesio Tapping for the Treatment of Patients With Acute Low Back Pain: A Randomized Control Trial
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Conventional Physical Therapy|OTHER: Kinesio Tapping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of COVID-19 Pandemic on Out-of-Pocket Costs, Lost Wages, and Unemployment in Patients With Breast Cancer Undergoing Breast Surgery
Status: RECRUITING
Conditions: Breast Ductal Carcinoma In Situ|COVID-19 Infection|Hereditary Breast Carcinoma|Invasive Breast Carcinoma
Interventions: OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Noninvasive Diagnostics in Left Ventricular Assist Device Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure|Artificial Heart Device User
Interventions: OTHER: Recording of LVAD data during routine visits and daily life.|OTHER: Recording of daily activity using wristwatch accelerometers.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Observational Study of Patients With Chronic Hepatitis C Virus (HCV) Infected With HCV Genotype 1 Low Virus Load (LVL 1) and Effect of PegIntron Plus Rebetol Treatment (Study P04793 Part 2)
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Standard of Care PegIntron|DRUG: Standard of Care Ribavirin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Evaluating Desvenlafaxine Succinate Sustained-release (DVS SR) in Adult Outpatients With Pain Associated With Diabetic Peripheral Neuropathy
Status: TERMINATED
Conditions: Diabetic Neuropathies|Pain
Interventions: DRUG: DVS SR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Treat and Extend Regimen of Intravitreal Aflibercept for Macular Edema Secondary to CRVO
Status: COMPLETED
Conditions: Central Retinal Vein Occlusion
Interventions: DRUG: Aflibercept (Eylea, BAY86-5321)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficiency of Bioactive Pit and Fissure Sealant
Status: NOT_YET_RECRUITING
Conditions: Pit and Fissure Sealant
Interventions: OTHER: BioCoat® by Premier®|OTHER: UltraSeal XT™ plus by Ultradent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Pilot Study to Evaluate the Safety and Efficacy of the Apica Access, Stabilization and Closure (ASC™) Device
Status: COMPLETED
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: Apica Cardiovascular ASC Access, Stability and Closure Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Assess the Immunogenicity and Safety of the Vero Cell-derived JE Vaccine in Korea
Status: COMPLETED
Conditions: Japanese Encephalitis
Interventions: BIOLOGICAL: JE vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Long-term Safety and Tolerability of Cenerimod in Adults With Systemic Lupus Erythematosus
Status: ENROLLING_BY_INVITATION
Conditions: Lupus Erythematosus, Systemic
Interventions: DRUG: Cenerimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemo-radio-immunotherapy With Nivolumab and Ipilimumab Treatment in Locally Advanced Cervical Cancer Patients
Status: WITHDRAWN
Conditions: Cervical Cancer ≥ FIGO IIB and or Lymph Node Metastases
Interventions: DRUG: Pre-Chemo-radio-immunotherapy Treatment (Nivolumab/Ipilimumab)|DRUG: Concurrent Chemo-radio-immunotherapy (Nivolumab/Ipilimumab)|PROCEDURE: Maintenance Treatment (Nivolumab/Ipilimumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remifentanil Infusion Alone During the Closure Period for Early Emergence Following Craniotomy
Status: COMPLETED
Conditions: Supratentorial Neoplasms
Interventions: DRUG: Remifentanil|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy in Treating Patients With Metastatic or Unresectable Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: fluorouracil|DRUG: gemcitabine hydrochloride|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of App Based Diabetes Training Program in Conjunction With the BD Nano Pen Needle in People With T2 Diabetes
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: DEVICE: BD Diabetes Care Application (for mobile devices) PLUS use of BD Nano Pen Needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Potential Association of a Common L-FABP Polymorphism With Lipid-induced Hepatic Insulin Resistance
Status: COMPLETED
Conditions: Wildtype|Polymorphism Liver FABP
Interventions: PROCEDURE: measurement of lipid-induced hepatic insulin resistance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Effectiveness of Primary Care-based Interventions for Pediatric ADHD
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: ADHD Group Visits|BEHAVIORAL: ADHD Group Visits plus Online Discussion Portal|BEHAVIORAL: Computer Decision Support
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Assess the Pharmacokinetics of Dapivirine (TMC120) Vaginal Microbicide Gel
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: dapivirine (TMC120) vaginal gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Repetitive Transcranial Magnetic Stimulation in Patients With Opioid Use Disorders
Status: UNKNOWN
Conditions: Transcranial Magnetic Stimulation|Heroin Dependence
Interventions: DEVICE: Active rTMS|DEVICE: Sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Light Therapy in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DEVICE: active light therapy : Light therapy: DayVia lamp 10000 lux|DEVICE: Placebo light therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TARGET: A Study to Evaluate the Treatment of Patients With Acute Decompensated Heart Failure (ADHF) Using an Automated Fluid Management System
Status: UNKNOWN
Conditions: Congestive Heart Failure
Interventions: DEVICE: Reprieve Cardiovascular System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 181.
Status: COMPLETED
Conditions: Ulcerative Colitis|Crohn's Disease
Interventions: DRUG: AMG 181|OTHER: Placebo for AMG 181
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Diuretics on Mineral and Bone Disorder in Chronic Kidney Disease Patients
Status: UNKNOWN
Conditions: Secondary Hyperparathyroidism|Chronic Kidney Disease
Interventions: DRUG: Hydrochlorothiazide|DRUG: Furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluate the Use of Paravertebral Block in Reconstructive Breast Surgery
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: Paravertebral Block|DRUG: Propofol|DRUG: Fentanyl|DRUG: Ropivacaine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Decision Support to Implement ED-initiated Buprenorphine for OUD
Status: COMPLETED
Conditions: Clinical Decision Support|Buprenorphine|Opioid-use Disorder
Interventions: BEHAVIORAL: Clinical Decision Support (CDS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety, Tolerability, PK, ECG Effects, Food Effect, and Drug-drug Interaction (DDI) of Hormonal Contraceptives of PTI-428 in Healthy Female Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: PTI-428|OTHER: Placebo|DRUG: ethinyl estradiol and levonorgestrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ingenol Mebutate Compared to Cryotherapy for the Treatment of Skin Lesions
Status: WITHDRAWN
Conditions: Actinic Keratosis
Interventions: DRUG: Ingenol mebutate|PROCEDURE: cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacist Use of ECG to Inform Drug Therapy Decisions for Patients Receiving QT Prolonging Medications
Status: COMPLETED
Conditions: Torsades de Pointe Caused by Drug (Disorder)|Torsades de Pointes|Qt Interval, Variation in
Interventions: OTHER: Pharmacist Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sharklet Catheter Study
Status: UNKNOWN
Conditions: Urinary Catheter|Urinary Tract Infections
Interventions: DEVICE: Radiance™ Clear Sharklet® Silicone Foley Catheter|DEVICE: Silicone Foley Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Reduction of Left Ventricular Hypertrophy After Eplerenone Therapy
Status: COMPLETED
Conditions: Hypertension,Essential|Obstructive Sleep Apnea|Left Ventricular Hypertrophy
Interventions: DRUG: Eplerenone 50 mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Arixtra (Fondaparinux Sodium) to Prevent Blood Clots in Women Undergoing Abdominopelvic Surgery for Likely Gynecologic Malignancy
Status: TERMINATED
Conditions: Venous Thrombosis
Interventions: DRUG: Arixtra (fondaparinux sodium)|DEVICE: Intermittent compression devices (ICD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Chronic Bronchiolitis or Resistant Asthma?
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Erythromycin, Azithromycin , Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of CEM-102 Compared to Linezolid in Acute Bacterial Skin Infections
Status: COMPLETED
Conditions: Skin Diseases, Bacterial
Interventions: DRUG: CEM-102|DRUG: Linezolid|DRUG: CEM-102
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lipid Biomarkers for Diabetic Heart Disease
Status: COMPLETED
Conditions: Type II Diabetes Mellitus|Diabetes Complications
Interventions: DRUG: Fenofibrate|DRUG: Placebo for fenofibrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Sleep Laboratory Study to Investigate the Safety and Efficacy of the Rotigotine Skin Patch in Subjects With Restless Legs Syndrome and End-Stage Renal Disease Requiring Hemodialysis
Status: COMPLETED
Conditions: Restless Legs Syndrome|End-Stage Renal Disease
Interventions: DRUG: Rotigotine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-oral Treatment of OLP With Rivelin®-CLO Patches
Status: COMPLETED
Conditions: Oral Lichen Planus
Interventions: DRUG: Clobetasol Propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults
Status: RECRUITING
Conditions: Cognitive Dysfunction|Mobility Limitation|Frail Elderly
Interventions: BEHAVIORAL: Walking Exercise|DEVICE: Prefrontal Active tDCS|DEVICE: Prefrontal Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Abnormalities of the Nervous System in the Occurrence of Intradialytic Arterial Hypotension
Status: COMPLETED
Conditions: Hemodialysis Complication
Interventions: DIAGNOSTIC_TEST: Cutaneous conductance to chlorine by SUDOSCAN
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: GCWB1001 Evaluates the Effectiveness and Safety of Respiratory Health
Status: UNKNOWN
Conditions: Respiratory Symptoms
Interventions: DIETARY_SUPPLEMENT: Lactobacillus plantarum|OTHER: maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Testing of a Candy in Five Different Versions for the Additional Humidification of the Oral Cavity
Status: COMPLETED
Conditions: Xerostomia|Dryness of Mouth
Interventions: OTHER: V01 candy|OTHER: V02 candy|OTHER: V03 candy|OTHER: V04 candy|OTHER: V05 candy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Severe COVID-19 Pneumonia With Allogeneic Mesenchymal Stem Cells
Status: COMPLETED
Conditions: COVID-19 Pneumonia
Interventions: BIOLOGICAL: Mesenchymal Stem Cells (MSCs)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transitioning To IV Remodulin From Ventavis in Patients With PAH: Safety, Efficacy and Treatment Satisfaction
Status: TERMINATED
Conditions: Hypertension, Pulmonary
Interventions: DRUG: treprostinil sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain
Status: UNKNOWN
Conditions: Symptomatic Periapical Periodontitis
Interventions: DRUG: Amoxicillin/Clavulanate Potassium 875 mg-125 mg oral tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Randomized, Double-blind Phase II Trial to Evaluate GM1 Prevention of Peripheral Neuropathy in Patients With Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: To Evaluate the Effectiveness of GM1 in the Prevention of Albumin-paclitaxel Therapy Induced Peripheral Neuropathy in Breast Cancer Patients
Interventions: DRUG: Monosialotetrahexose ganglioside sodium injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Histochemical Study of Vitiligo in Sohag University Hospital Patients
Status: NOT_YET_RECRUITING
Conditions: Vitiligo
Interventions: DIAGNOSTIC_TEST: Light microscopic studies|DIAGNOSTIC_TEST: Immunohistochemical studies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of LibiGel® for Treatment of Hypoactive Sexual Desire Disorder in Postmenopausal Women
Status: COMPLETED
Conditions: Hypoactive Sexual Desire Disorder
Interventions: DRUG: testosterone gel|DRUG: placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Analyze the Efficacy of a Supplement Extracted From Persimmon on Overweight / Obesity.
Status: COMPLETED
Conditions: Supplementation|Obesity
Interventions: DIETARY_SUPPLEMENT: Experimental Product Caqui|DIETARY_SUPPLEMENT: Control product placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Feasibility Study for Evaluating the Effect of Electrical Stimulation on Lower Esophageal Sphincter Pressure and Esophageal Acid Exposure in Patients With Gastroesophageal Reflux Disease
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DEVICE: EndoStim LES Stimulation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Blood Gases, Disturbance of Breath During Sleep and Cardiovascular Co-morbidity in COPD Patients
Status: COMPLETED
Conditions: Pulmonary Disease|Chronic Obstructive|Hypercapnia|Hypoxemia|Arrhythmias, Cardiac
Interventions: DRUG: supplementary oxygen|DRUG: zopiclone|OTHER: alcohol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Safety and Efficacy of Alveolar Bone Defect Repair Induced by Gelatin Sponge-loaded Apoptotic Vesicle Complex
Status: NOT_YET_RECRUITING
Conditions: Third Molar Extraction
Interventions: DRUG: Gelatin sponge-loaded apoptotic vesicle complex（Kuaikang®)|DRUG: Gelatin sponge only （Kuaikang®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rituxan/Bendamustine/PCI-32765 in Relapsed DLBCL, MCL, or Indolent Non-Hodgkin's Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Splenic Marginal Zone Lymphoma|Waldenstrom Macroglobulinemia
Interventions: DRUG: BTK inhibitor PCI-32765|BIOLOGICAL: rituximab|DRUG: bendamustine hydrochloride|OTHER: pharmacogenomic studies|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Passive Ultrasonic Irrigation on the Reduction of Bacteria and Endotoxins in Root Canals
Status: COMPLETED
Conditions: Tooth, Nonvital
Interventions: DEVICE: Ultrasonic Irrigation|DEVICE: Non-Ultrasonic Irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Crossover Study to Compare the Pharmacokinetics of Subcutaneous and Intravenous Ceftriaxone Administration
Status: COMPLETED
Conditions: Pharmacokinetics in Healthy Adults
Interventions: DRUG: ceftriaxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Oral Cyclosporine in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Cyclosporine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metal Ion Levels in Stryker Trident II Tritanium System With Modular Dual Mobility (MDM) Liner, Ceramic Head, and SecurFit Advanced Stems
Status: ACTIVE_NOT_RECRUITING
Conditions: Hip Pain
Interventions: OTHER: Blood levels drawn
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Astigmatism Management in Cataract Surgery With the AcrySof Toric Intraocular Lens
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: AcrySof Toric intraocular lens, model SN60TT|DEVICE: AcrySof Monofocal IOL, model SN60AT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Beclomethasone/Formoterol in Extra-fine Formulation on Quality of Life and SAD in COPD Patients.
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Beclomethasone Dipropionate/Formoterol Fumarate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Project Guard: Reducing Alcohol Misuse/Abuse in the National Guard
Status: COMPLETED
Conditions: Alcohol Use
Interventions: BEHAVIORAL: Smartphone brief intervention (SP-BI)|OTHER: Enhanced Usual Care (EUC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: AED Use in Out-of-Hospital Cardiac Arrest: A New Algorithm Named "One Shock Per Minute"
Status: COMPLETED
Conditions: Heart Arrest|Ventricular Fibrillation
Interventions: OTHER: One shock per minute AED protocol|OTHER: Guidelines 2000 AED protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenetics of Ace Inhibitor-Associated Angioedema
Status: COMPLETED
Conditions: Hypertension|Diabetes Type 2
Interventions: DRUG: Sitagliptin (DPP4 inhibitor)|DRUG: Substance P,|DRUG: bradykinin|DRUG: enalaprilat (ACE inhibitor)|DRUG: Glucagon-like peptide 1|DRUG: brain natriuretic peptide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BKM120 and Fulvestrant for Treating Postmenopausal Patients With Estrogen Receptor-Positive Stage IV Breast Cancer
Status: COMPLETED
Conditions: Estrogen Receptor-positive Breast Cancer|Recurrent Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: BKM120|DRUG: Fulvestrant|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT