pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: HORIZON: A Phase II Study to Evaluate the Safety and Efficacy of Two Doses of GT005
Status: TERMINATED
Conditions: Dry Age-related Macular Degeneration
Interventions: DRUG: GT005: Medium Dose|DRUG: GT005: High Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autoimmune Dysregulation in Pigmentary Glaucoma
Status: COMPLETED
Conditions: Pigmentary Glaucoma|Primary Open Angle Glaucoma|Cataract
Interventions: PROCEDURE: Trabeculectomy|PROCEDURE: Trabeculectomy and cataract surgery|PROCEDURE: Cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Botulinum Toxin at Moderate to Severe Glabellar Lines
Status: COMPLETED
Conditions: Glabellar Frown Lines
Interventions: BIOLOGICAL: ATGC-100 100U|BIOLOGICAL: Botox 100U
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sealing of Occlusal Dentin Caries in Primary Molars.
Status: COMPLETED
Conditions: Caries; Dentin|Fissure, Dental|Dental Caries in Children|Glass Ionomer Cement|Fissure Sealants
Interventions: PROCEDURE: Resin based sealing [RBS]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Liraglutide Versus Insulin on Liver Fat Fraction in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Nonalcoholic Fatty Liver Disease|Nonalcoholic Steatohepatitis|Type 2 Diabetes
Interventions: DRUG: Liraglutide-metformin vs insulin-metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Atrial Fibrillation in Relationship to Plasma Biomarkers
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DIAGNOSTIC_TEST: Peripheral blood samples for routine analysis including NT-proBNP and plasmatic biomarkers.|DIAGNOSTIC_TEST: Echocardiography|DIAGNOSTIC_TEST: ECG Holter monitor|DIAGNOSTIC_TEST: Standardized Mini-Mental Status Exam (SMMSE)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CITrate and Evodial for Effective Dialysis (CITED) Study
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DEVICE: EVODIAL dialyzer and Selectbag citrate|DEVICE: Regional citrate anticoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Effectiveness and Tolerability of Prolonged-release Tacrolimus After Paediatric Kidney Transplantation
Status: RECRUITING
Conditions: Pediatric Kidney Disease
Interventions: DRUG: Envarsus®|DRUG: Prograf
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Symptomatic Therapy of Uncomplicated Lower Urinary Tract Infections in the Ambulatory Setting.
Status: TERMINATED
Conditions: Urinary Tract Infections
Interventions: DRUG: Diclofenac|DRUG: Norfloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mass Drug Administrations of DHA-PQP to Accelerate Towards Malaria Elimination in Magude District, Southern Mozambique
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Dihydroartemisinin-piperaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melphalan, Arsenic Trioxide, and Ascorbic Acid in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: WITHDRAWN
Conditions: Stage II Multiple Myeloma|Stage III Multiple Myeloma|Refractory Plasma Cell Neoplasm
Interventions: DRUG: arsenic trioxide|DRUG: ascorbic acid|DRUG: melphalan|PROCEDURE: chemosensitization/potentiation|PROCEDURE: chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation of Echocardiographic Indices and Blood Biomarkers in Group 1 Pulmonary Hypertension
Status: UNKNOWN
Conditions: Pulmonary Hypertension
Interventions: DEVICE: swan ganze catheter /echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Trial to Assess the Safety, Tolerability, and Immunogenicity of Bivalent rLP2086 Vaccine When Given to Healthy Young Adults Aged >=18 to <26 Years.
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: rLP2086|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of VPM1002 in Reducing SARS-CoV-2 (COVID-19) Infection Rate and Severity
Status: COMPLETED
Conditions: SARS-CoV-2 Infection
Interventions: BIOLOGICAL: VPM1002|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: High Voltage Pulsed Current and Microcurrent Stimulation Therapy in Treatment of Wounds.
Status: COMPLETED
Conditions: Wound|Ulcer
Interventions: OTHER: High voltage pulsed current|OTHER: Microcurrent therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MK2206 and Paclitaxel in Treating Patients With Locally Advanced or Metastatic Solid Tumors or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Adult Solid Neoplasm|Recurrent Breast Carcinoma|Stage IV Breast Cancer
Interventions: DRUG: Akt Inhibitor MK2206|OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of High Versus Low-level Laser Therapy in Patients of Lumber Radiculopathy
Status: COMPLETED
Conditions: Lumbar Radiculopathy
Interventions: OTHER: High-level laser therapy|OTHER: Low-level laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Breathing Exercises With and Without Inspiratory Muscle Training in COPD Patients
Status: NOT_YET_RECRUITING
Conditions: COPD
Interventions: OTHER: BREATHING EXERCISE|OTHER: BREATHING EXERCISE REGIMEN COUPLED WITH BREATHER DEVICE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: 3,3'-Dioxo-2,2'-Bisindolylidene-5,5'-Disulfonate Disodium 0.8% Solution as an Aid for Ureteral Patency
Status: COMPLETED
Conditions: Ureter Injury
Interventions: DRUG: 3,3'-Dioxo-2,2'-bisindolylidene-5,5'-disulfonate disodium 0.8%|DRUG: Saline spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Role of N-acetyl-l-cysteine (NAC) as an Adjuvant to Opioid Treatment in Patients With Chronic Neuropathic Pain
Status: COMPLETED
Conditions: Neuropathic Pain
Interventions: DRUG: N-acetyl-l-cysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Letrozole in Breast Cancer Who Have Received 5 Years of Aromatase Inhibitor Therapy
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: letrozole|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Cost-effectiveness in Two Empirically-based Psychotherapies for Borderline Personality Disorder: A Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Treatment 1:Dialectical Behavior Therapy (DBT)|Treatment 2:Dynamic Deconstructive Psychotherapy (DDP)|Placebo
Interventions: BEHAVIORAL: DBT|BEHAVIORAL: DDP|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeting of Immune Response After Pneumococcal Vaccination
Status: COMPLETED
Conditions: Pneumococcal Pneumonia
Interventions: BIOLOGICAL: Pneumococcal polysaccharide vaccine|BIOLOGICAL: pneumococcal conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cryoablation Combined With Tislelizumab Plus Lenvatinib In Previously Treated Solid Tumors (CASTLE-11)
Status: RECRUITING
Conditions: Solid Tumor, Adult
Interventions: DRUG: Tislelizumab|DRUG: Lenvatinib|PROCEDURE: Cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Training Effects of Tinkering Activities on Cognitive Flexibility in Older Adults From Communities
Status: RECRUITING
Conditions: Cognitive Training
Interventions: BEHAVIORAL: Tinkering Activities|BEHAVIORAL: Control Tinkering Activities|BEHAVIORAL: Board Games Activities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Comparing EBUS & EUS to Mediastinoscopy in Staging and Detection of Lung Cancer
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer
Interventions: PROCEDURE: Mediastinoscopy/thoracoscopy|PROCEDURE: EBUS/EUS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioequivalence Study to Compare Fluticasone Furoate (FF) 1-strip Inhaler With FF 2-strip Inhaler and With FF/Vilanterol Combination
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone Furoate (200mcg unit strength)|DRUG: Fluticasone Furoate/Vilanterol (200/25mcg unit strength)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Diabetes Study With Rosiglitazone Monotherapy Versus Metformin Or Glyburide/Glibenclamide
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Rosiglitazone|DRUG: glyburide|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of the IJV or the SCV Approach for Ultrasound-guided Implantation of TIVAD
Status: UNKNOWN
Conditions: Venous Thrombosis|Catheter-Related Infections|Catheter Mechanical Failure Rate
Interventions: PROCEDURE: Subclavian vein approach|PROCEDURE: internal jugular vein approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Safety and Efficacy Study of FCR001 in Adults With Rapidly Progressive Diffuse Cutaneous Systemic Sclerosis
Status: WITHDRAWN
Conditions: Diffuse Cutaneous Systemic Sclerosis
Interventions: BIOLOGICAL: FCR001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vision Performance Evaluation of TECNIS EYHANCE™ With TECNIS SIMPLICITY™ Compared to TECNIS® 1-piece Intraocular Lenses
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Tecnis Eyhance|DEVICE: Tecnis 1 piece IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Formula Diet on Body Weight, Body Composition, and Biomarkers for Disease Compared to a Standard Diet
Status: COMPLETED
Conditions: Body Weight Changes
Interventions: BEHAVIORAL: MicroDiet|BEHAVIORAL: Healthy Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab Deruxtecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of a Temporary Sub-Placental Uterine Tourniquet in Minimizing Intraoperative Blood Loss in Management of Placenta Accreta Spectrum Disorder by a Retrograde Cesarean Hysterectomy (Bladder Last)
Status: RECRUITING
Conditions: Placenta Accreta
Interventions: PROCEDURE: A temporary sub-placental Uterine Tourniquet in management of Placenta Accreta Spectrum disorder by a retrograde cesarean hysterectomy (Bladder Last)|PROCEDURE: Retrograde cesarean hysterectomy (Bladder Last) for management of Placenta Accreta Spectrum disorder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Morphine In Acute Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: morphine chlorhydrate|DRUG: saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of Single Rising Oral Doses of BI 1060469 in Healthy Asian Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1060469|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of GZR18 Injection in Obese/Overweight Subjects
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: DRUG: GZR18|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tandem High-dose Chemotherapy and Autologous Stem Cell Rescue in Patients With High-risk Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: DRUG: Cyclophosphamide|DRUG: Etoposide|DRUG: Carboplatin|DRUG: Thiotepa|DRUG: Melphalan|RADIATION: Total body irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Verses Delayed Surgical Periodontal Therapy After Endodontic Treatment in Endo Perio Lesion With Communication
Status: COMPLETED
Conditions: Attachment Loss|Tooth,Non Vital
Interventions: PROCEDURE: Immediate periodontal surgery|PROCEDURE: Delayed periodontal surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Personalized Transcranial Cortical Neurostimulation for Pain Relief
Status: NOT_YET_RECRUITING
Conditions: Drug-resistant Neuropathic Pain
Interventions: DEVICE: tDCS (Transcranial Direct Current Stimulation)|DEVICE: tACS (Transcranial Alternating Current Stimulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GRC 27864 First in Man, Single Ascending Dose Study in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GRC 27864|DRUG: Celecoxib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bioavailability Study of Ciprofloxacin 1000 mg ER Tablets of Dr. Reddy's Under Fasting Conditions
Status: COMPLETED
Conditions: Fasting
Interventions: DRUG: CIPRO®XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing a 182mg Colon-targeted-delivery Peppermint Oil Capsule (Tempocol-ColoPulse®) and a 182mg Enteric-coated Peppermint Oil Capsule (Tempocol®), a Pharmacokinetic Study
Status: COMPLETED
Conditions: Irritable Bowel Syndrome|Abdominal Pain|Colonic Diseases|Visceral Pain
Interventions: DRUG: Menthae piperitae aetheroleum/peppermint oil (enteric coated capsule)|DRUG: Menthae piperitae aetheroleum/peppermint oil (colon-targeted-delivery capsule)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Balloon + Oxytocin Versus Oral Misoprostol to Induce Labor in Case of PROM (RUBAPRO2)
Status: RECRUITING
Conditions: Induction of Labor|Cervical Ripening|Premature Rupture of Fetal Membranes|Nulliparous
Interventions: DEVICE: Balloon for cervical ripening (Teleflex French Dufour catheter CH20 reference 174000)|DRUG: Oxytocin|DRUG: Misoprostol Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of 9 Doses vs 3 Doses of Post Operative Antibiotics in Live Liver Donors
Status: COMPLETED
Conditions: Antibiotic Prophylaxis|Postoperative Infection
Interventions: DRUG: Piperacillin + Tazobactam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Transmagnetic Stimulation on Conditioned Pain Modulation (CPM)
Status: COMPLETED
Conditions: Headache|Migraine
Interventions: DEVICE: TMS system MagPro x100, Tonica Elektronik A/S, Denmark|DEVICE: TMS system MagPro x100, Tonica Elektronik A/S, Denmark
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PD-1 Knockout Engineered T Cells for Castration Resistant Prostate Cancer
Status: WITHDRAWN
Conditions: Hormone Refractory Prostate Cancer
Interventions: BIOLOGICAL: PD-1 Knockout T Cells|DRUG: Cyclophosphamide|DRUG: IL-2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of V503, a 9-valent Human Papillomavirus (9vHPV) Vaccine in Females 12-26 Years of Age Who Have Previously Received GARDASIL™ (V503-006)
Status: COMPLETED
Conditions: Cervical Cancers|Vulvar Cancers|Vaginal Cancers|Genital Warts
Interventions: BIOLOGICAL: V503|BIOLOGICAL: Placebo to V503
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: SYSTANE® Family - Meibomian Deficiency
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: OTHER: SYSTANE® Lid Wipes|OTHER: SYSTANE® BALANCE|DIETARY_SUPPLEMENT: SYSTANE® Vitamins|OTHER: Microfiber towels (as warm compresses, with or without saline eye drops)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Exercise and Hyperlipidic Meal on Free Circulating DNA in Patients With Metastatic Colonic Cancer and Healthy Subjects
Status: NOT_YET_RECRUITING
Conditions: Colon Cancer
Interventions: OTHER: Moderate intensity physical effort|OTHER: Low intensity physical effort|OTHER: Hyperlipidic meal|DIAGNOSTIC_TEST: Measure of circulating DNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Influence of Leg Length Discrepancy on the Spinal Shape and Biomechanics in Functional and Idiopathic Scoliosis Patients
Status: COMPLETED
Conditions: Leg Length Discrepancy|Scoliosis
Interventions: BEHAVIORAL: Motion analysis of patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Educational Booklet for Foot-related Exercises for Prevention and Treatment in People With Diabetic Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathies
Interventions: OTHER: Educational and home-based physical therapy by foot-related exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise and Respiratory Training as Supportive Treatments for Patients With Chronic Pulmonary Hypertension
Status: COMPLETED
Conditions: Chronic Pulmonary Hypertension
Interventions: BEHAVIORAL: Exercise and Respiratory Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Brushing Plaque Removal Efficacy of a Battery-powered Toothbrush and a Manual Toothbrush
Status: COMPLETED
Conditions: Plaque, Dental
Interventions: DEVICE: Battery operated toothbrush|DEVICE: Manual toothbrush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A 52-Week, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Evaluate the Efficacy and Safety of a 200-mcg Dose of IPP-201101 Plus Standard of Care in Patients With Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Lupus Erythematosus, Systemic
Interventions: DRUG: IPP-201101|DRUG: Placebo|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study in Subjects With Chronic HCV and Underlying Hemophilia
Status: COMPLETED
Conditions: Hepatitis C Virus
Interventions: BIOLOGICAL: Pegylated-Interferon-lambda|DRUG: Ribavirin|DRUG: Daclatasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Understanding How Anaesthesia Affects ECT Outcomes
Status: COMPLETED
Conditions: Depression
Interventions: OTHER: Electroconvulsive Therapy (ECT) time interval + Anaesthetic (Thiopentone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of Intubating Devices in the Morbidly Obese
Status: COMPLETED
Conditions: Obesity
Interventions: DEVICE: McGrath|DEVICE: GlideScope|DEVICE: Direct Macintosh Laryngoscopy|DEVICE: Video-Mac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Anti-INFLammatory to Address Mood and Endothelial Dysfunction (INFLAMED)
Status: COMPLETED
Conditions: Major Depressive Disorder|Depression|Depressive Symptoms|Cardiovascular Disease (CVD)|Coronary Artery Disease (CAD)|Heart Disease
Interventions: DRUG: Pentoxifylline|OTHER: Placebo|BEHAVIORAL: Standard Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-blind, Placebo-controlled Trial Investigating the Role of a Personal Care Product on Vaginal Health
Status: COMPLETED
Conditions: Vaginal Personal Care
Interventions: OTHER: VM-02|DIETARY_SUPPLEMENT: Commercial Oral Probiotic Competitor|OTHER: VM-02 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase Ⅲ Clinical Study to Evaluate Protective Efficacy and Safety of a Recombinant Herpes Zoster Vaccine
Status: RECRUITING
Conditions: Vaccine-Preventable Diseases|Herpes Zoster
Interventions: BIOLOGICAL: Recombinant Herpes Zoster Vaccine|BIOLOGICAL: Recombinant Herpes Zoster Vaccine Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Residual Vein Thrombosis and the Optimal Duration of Low Molecular Weight Heparin in Cancer Patients With Deep Vein Thrombosis
Status: UNKNOWN
Conditions: Deep Vein Thrombosis|Cancer
Interventions: DRUG: low molecular weight heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of COVID-19 Vaccine（SARS-CoV-2 Variant(Omicron BA.5) mRNA Vaccine） in Participants Aged 18 Years and Over
Status: RECRUITING
Conditions: SARS-CoV-2
Interventions: BIOLOGICAL: SARS-CoV-2 Variant (Omicron BA.5) mRNA vaccine|DRUG: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Epinephrine on Systemic Absorption of Mepivacaine in Uremic Patients
Status: TERMINATED
Conditions: Renal Insufficiency, Chronic
Interventions: DRUG: Mepivacaine with epinephrine|DRUG: Plain mepivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Tracheal Suctioning and Expiratory Pause in Bronchial Hygiene
Status: RECRUITING
Conditions: Mechanical Ventilation
Interventions: OTHER: 5-Second Expiratory Pause|OTHER: 10-Second Expiratory Pause
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Naturalistic Safety Registry Of Celecoxib (CELEBREX(R)) And NSAIDs In Juvenile Idiopathic Arthritis
Status: TERMINATED
Conditions: Arthritis, Juvenile Rheumatoid
Interventions: DRUG: Celecoxib|DRUG: nsNSAIDs
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Nitrate-rich Fruit and Vegetable Supplement on Blood Pressure
Status: COMPLETED
Conditions: High Blood Pressure|Flow Mediated Dilation
Interventions: DIETARY_SUPPLEMENT: fruit and vegetable juice supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Cabozantinib and Nivolumab With Radiation Therapy for People With Renal Cell Carcinoma That Has Spread to the Brain
Status: RECRUITING
Conditions: Metastatic Renal Cell Carcinoma|Brain Metastases
Interventions: DRUG: Cabozantinib|DEVICE: Nivolumab|RADIATION: Stereotactic Radiosurgery (SRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of 1,550-nm Laser and Fractional Radiofrequency Microneedle for the Treatment of Acne Scars in Ethnic Skin
Status: COMPLETED
Conditions: Acne Scars
Interventions: DEVICE: Fraxel Restore|DEVICE: Fractora
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fluoroscopy Radiation Reduction During Sacral Neuromodulation Lead Placement
Status: RECRUITING
Conditions: Radiation Exposure|Overactive Bladder|Urge Incontinence|Urgency-frequency Syndrome
Interventions: PROCEDURE: Reduced radiation fluoroscopy|PROCEDURE: Conventional fluoroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Panaceo "MED" for IBS (Irritable Bowel Syndrome)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome|Microbial Colonization|Intestinal Disease
Interventions: OTHER: Zeolite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of PER-001 in Participants With Open-Angle Glaucoma
Status: RECRUITING
Conditions: Open-angle Glaucoma
Interventions: DRUG: PER-001 Intravitreal Implant - Low Dose|DRUG: PER-001 Intravitreal Implant - High Dose|DRUG: PER-001 Intravitreal Implant - Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Movement Control Training Associated With Conventional Physical Therapy is More Effective Than Conventional Physical Therapy Alone in Pain and Functional Performance?
Status: COMPLETED
Conditions: Patellofemoral Pain Syndrome
Interventions: OTHER: Conventional Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NFX-179 Topical Gel Treatment for Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF)
Status: COMPLETED
Conditions: Cutaneous Neurofibroma|Neurofibromatosis 1
Interventions: DRUG: NFX-179 gel|DRUG: Vehicle gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trajectories and Experiences of People With Multimorbidity in Spain (LOXO-MULTIPAP) Project: a Mixed Methods Study
Status: ENROLLING_BY_INVITATION
Conditions: Multimorbidity
Interventions: OTHER: Retrospective and prospective cohort|OTHER: Focus group, semi-structured interviews and Photovoice|OTHER: Systematic review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Implementation of a Personalized Medicine (Pharmacogenomics) Service in a Community Pharmacy
Status: COMPLETED
Conditions: Stroke|Transient Ischemic Attack|Myocardial Infarction
Interventions: OTHER: Pharmacogenomics testing for clopidogrel responsiveness
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Safety and Efficacy of GTS21 in Adults With Attention-deficit Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: GTS21/Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety, Pharmacokinetics, and Clinical Effects of Intravenously Administered PT-112 Injection in Subjects With Advanced Solid Tumors and Subsequent Dose Expansion Cohorts
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumors|CRPC|mCRPC|Metastatic Castrate-resistant Prostate Cancer|PT-112|Prostatic Neoplasms|Genital Neoplasms, Male|Urogenital Neoplasms|Neoplasms by Site
Interventions: DRUG: PT-112 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel-induced Polyneuropathy in Breast Cancer: Early Detection, Risk Factors, Quality of Life and Lifestyle Outcomes
Status: RECRUITING
Conditions: Breast Neoplasms|Breast Cancer|Early-stage Breast Cancer|Non-Metastatic Breast Carcinoma|Polyneuropathy Due to Drugs|Polyneuropathy; Drug|Chemotherapy-induced Peripheral Neuropathy|Quality of Life
Interventions: DEVICE: Garmin smartwatch|OTHER: REBECCA Mobile application|OTHER: REBECCA PC plug-in
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prevalence of Transthyretin Amyloidosis in Hypertrophic Cardiomyopathy
Status: COMPLETED
Conditions: Cardiac Amyloidosis|Amyloidosis in Transthyretin (TTR)|Hypertrophic Cardiomyopathy (HCM)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Reminder to Improve Appropriateness of Echocardiography
Status: COMPLETED
Conditions: Echocardiography
Interventions: OTHER: Clinical Reminder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Prevalence of Sarcopenia and Undernutrition in Patients With Cirrhosis and Abdominal Hernia
Status: COMPLETED
Conditions: Cirrhosis|Sarcopenia|Malnutrition|Hernia, Abdominal
Interventions: DIAGNOSTIC_TEST: Computed Tomography Scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Arteriovenous Fistula: Conventional Angioplasty vs Drug Eluting Balloon-assisted Maturation Intervention Clinical Trial
Status: UNKNOWN
Conditions: Stenosis of Arteriovenous Dialysis Fistula
Interventions: DEVICE: Drug-eluting balloon angioplasty (DEBA)|DEVICE: Conventional Balloon Angioplasty (CBA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Ferumoxytol for the Treatment of Iron Deficiency Anemia (IDA) in Pediatric Subjects
Status: RECRUITING
Conditions: Iron Deficiency Anemia
Interventions: DRUG: ferumoxytol|DRUG: Iron sucrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In-hospital Diabetes Management With Flash Glucose Monitoring (isCGM) - the INDIGO Study, Part A
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus|Diabetes Mellitus
Interventions: OTHER: isCGM group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Haplo-identical SCT for High Risk (HR) Hematologic Malignancies w/Post-Transplant In-Vivo T-cell Depletion
Status: WITHDRAWN
Conditions: Leukemia|Lymphoma|MDS
Interventions: DRUG: Conditioning Regimen & GVHD Prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Neurogenic Acupoint CUPPING ON WOMEN WITH CHRONIC PELVIC PAIN
Status: UNKNOWN
Conditions: Chronic Pelvic Pain
Interventions: COMBINATION_PRODUCT: dry cupping|OTHER: Life style modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: FrAilty Care and wEll-funcTion in Community Dwelling Older Adults
Status: UNKNOWN
Conditions: Frailty|Sarcopenia|Aging
Interventions: BEHAVIORAL: Consultation|BEHAVIORAL: Online Support|BEHAVIORAL: Empowered
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy, Safety and Immunogenicity of Rotavirus RV3 Vaccine (Bio Farma) in Neonates
Status: COMPLETED
Conditions: Rotavirus Gastroenteritis
Interventions: BIOLOGICAL: Rotavirus RV3 Vaccine (Bio Farma)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Microstructural Analysis of Ingestive Behavior After Roux-en-Y Gastric Bypass - Pilot
Status: COMPLETED
Conditions: Meal|Obesity, Morbid|Food Deprivation|Bariatric Surgery|Roux-en-y Gastric Bypass|Ingestive Microstructure|Drinking Behavior|Drinkometer
Interventions: PROCEDURE: Roux-en-Y gastric bypass
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Liberia Insecticide Treated Durable Wall Linings Study: Protocol for a Cluster Randomised Trial (DL)
Status: COMPLETED
Conditions: Malaria, Falciparum|Anemia
Interventions: DEVICE: Insecticide treated wall lining
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 3)
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: Mirikizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial to Correlate Radiographic Response Induced By Gefitinib With Mutations in the Protein-Tyrosine Kinase Domain of the EGF Receptor Gene
Status: COMPLETED
Conditions: Lung Cancer|Non-small Cell Lung Cancer|Bronchioloalveolar Cancer
Interventions: DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interferon Alfa Therapy Based on Th17 Profile in Membranous Nephropathy
Status: NOT_YET_RECRUITING
Conditions: Membranous Nephropathy
Interventions: DRUG: Peginterferon Alfa-2A 180 MCG/ML Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone Response to Soy Isoflavones in Women
Status: COMPLETED
Conditions: Osteopenia|Osteoporosis
Interventions: DIETARY_SUPPLEMENT: Soy isoflavones|DIETARY_SUPPLEMENT: Extract tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Safety of Rexin-G Gene Transfer for Advanced Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: GENETIC: Rexin-G Dose 1|GENETIC: Rexin-G Dose 2|GENETIC: Rexin-G Dose 3|GENETIC: Rexin-G Dose 4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Radiotherapy Followed by Transanal Endoscopic Microsurgery for T1-T2 Extraperitoneal Rectal Cancer
Status: COMPLETED
Conditions: RECTAL CANCER
Interventions: PROCEDURE: SRT-TEM|PROCEDURE: LRT-TEM|PROCEDURE: Transanal Endoscopic Microsurgery (TEM)|PROCEDURE: Total Mesorectal Excision (TME)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Invasive and Non-invasive Measurement of CI and SVR in Liver Transplantation
Status: UNKNOWN
Conditions: Living Donor Liver Transplantation
Interventions: DIAGNOSTIC_TEST: Clearsight (finger cuff)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Measurement of Blood Loss in Adenotonsillectomy During General Anesthesia According to the Application of Nondepolarizing Muscle Relaxants
Status: RECRUITING
Conditions: Anesthesia|Neuromuscular Blockade|Intraoperative Bleeding|Intraoperative Blood Loss|Post Operative Hemorrhage|Anesthesia Complication
Interventions: PROCEDURE: conventional cold tonsillectomy and curettage adenoidectomy|DRUG: Rocuronium Bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: More Than 50% of the Patients With Clinically Unifocal T1b/Small T2 Node Negative Papillary Thyroid Carcinoma Scheduled for Thyroid Lobectomy May Require Completion Thyroidectomy if the Nodal Status is Evaluated
Status: COMPLETED
Conditions: Papillary Thyroid Cancer|Papillary Carcinoma|Thyroid Cancer|Thyroid Carcinoma|Thyroid Cancer, Papillary|Lymph Node Metastasis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence Study of Two Formulations of Atorvastatin Film-coated Tablets 40 mg in Healthy Volunteers Under Fasting Conditions
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Atorvastatin film-coated tablet 40 mg|DRUG: Liprimar® film-coated tablet 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of Immune Response Against the Strain of Neisseria Meningitidis B: 14, P1-7, 16 in Patients Having to be Vaccinated MenBVac® (Extension EFFIVAC)
Status: COMPLETED
Conditions: Neisseria Meningitidis
Interventions: BIOLOGICAL: MenBvac
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hypertonic Saline for Fluid Resuscitation After Cardiac Surgery
Status: COMPLETED
Conditions: Cardiovascular Diseases|Valvular Heart Disease
Interventions: DRUG: Hypertonic saline|DRUG: 0.9% saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Counter Measure for the Effects of Immune and Microbiome Changes in Environments With Limited ANtigen Diversity (ICELAND-TWO)
Status: RECRUITING
Conditions: Confinement and Isolation
Interventions: DIETARY_SUPPLEMENT: Bifidobacterium longum 1714|DIETARY_SUPPLEMENT: placebo sachet containing maltodextrin and magnesium stearate.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Long-Term Study of Aripiprazole in Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Antidepressant + Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Celecoxib in Treating Patients With Stage III Colon Cancer Previously Treated With Surgery
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: celecoxib|DRUG: 5-fluorouracil|OTHER: placebo|DRUG: oxaliplatin|DRUG: leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: COnventional vs. Optimised PERiprocedural Analgosedation vs. Total IntraVEnous Anaesthesia for Pulsed-Field Ablation (COOPERATIVE-PFA)
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DRUG: Remimazolam|DRUG: Propofol|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intravesical Platelet-rich Plasma Injection in Patients With Interstitial Cystitis/Bladder-A Retrospective Study
Status: NOT_YET_RECRUITING
Conditions: Safety and Effectiveness Between Intravesical Platelet-rich Plasma Injection in Patients With Interstitial Cystitis/Bladder
Interventions: PROCEDURE: PRP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase I Clinical Study With Investigational Compound LTT462 in Adult Patients With Specific Advanced Cancers.
Status: TERMINATED
Conditions: Ovarian Neoplasms|Non-Small-Cell Lung Carcinoma|Melanoma|Other Solid Tumors
Interventions: DRUG: LTT462
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMA401 TCER® in Recurrent and/or Refractory Solid Tumors
Status: RECRUITING
Conditions: Refractory Cancer|Recurrent Cancer|Solid Tumor, Adult|Cancer
Interventions: BIOLOGICAL: IMA401 (Phase Ia)|BIOLOGICAL: IMA401 (Phase Ib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Down Syndrome - Comparison of Screening Methods in the 1st and 2nd Trimesters
Status: UNKNOWN
Conditions: Down Syndrome|Chromosome Abnormalities
Interventions: PROCEDURE: Ultrasound|PROCEDURE: Serum screen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of the Safety and Tolerability of ASP0777 in Subjects With Alzheimer's Disease (AD) Taking a Stable Dose of Donepezil
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: ASP0777|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Simplification Study of HIV-1 Infected Patients With Virological Suppression Under the Combination of Lamivudine (150 mg BID) Plus Raltegravir (400 mg BID) Switching to Lamivudine (300 mg QD) Plus Raltegravir (1200 mg QD) : Roll-over Study of the RALAM
Status: UNKNOWN
Conditions: HIV Infections|HIV-1-infection|HIV Seropositivity
Interventions: DRUG: Raltegravir|DRUG: Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Social Incentives and Gamification for Weight Loss Promotion
Status: COMPLETED
Conditions: Weight Loss|Obesity|Physical Activity
Interventions: BEHAVIORAL: Gamification|BEHAVIORAL: Share Data with PCP|BEHAVIORAL: Feedback on weight|BEHAVIORAL: Feedback on step counts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: dEtection of rheumAtoid aRthritis - Interstitial Lung dIseasE by Thoracic ultRasound
Status: NOT_YET_RECRUITING
Conditions: Rheumatoid Arthritis|Interstitial Lung Disease|Thoracic Ultrasound|Lung Ultrasound
Interventions: DIAGNOSTIC_TEST: Lung ultrasound (LUS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Lighted Stylet and GlideScope for Double-lumen Endobronchial Intubation
Status: UNKNOWN
Conditions: Intubation;Difficult
Interventions: DEVICE: GlideScope|DEVICE: Lighted stylet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Revascularization in Heart Failure Trial - REHEAT 2
Status: UNKNOWN
Conditions: Left Ventricular Ejection Fraction|Myocardial Revascularization|Ischemic Heart Disease
Interventions: PROCEDURE: Percutaneous Coronary Intervention|PROCEDURE: Coronary Artery Bypass Grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT