pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Lenacapavir for HIV Pre-Exposure Prophylaxis in People Who Are at Risk for HIV Infection
Status: ACTIVE_NOT_RECRUITING
Conditions: Pre-Exposure Prophylaxis of HIV Infection
Interventions: DRUG: Oral Lenacapavir (LEN)|DRUG: F/TDF|DRUG: Sub-cutaneous (SC) Lenacapavir (LEN)|DRUG: Placebo SC LEN|DRUG: PTM F/TDF|DRUG: PTM Oral LEN|DRUG: F/TAF (for US participants only)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia
Status: RECRUITING
Conditions: Alzheimer Disease|Dementia|Primary Progressive Aphasia|Aphasia|Progressive Aphasia|Progressive Aphasia in Alzheimer's Disease
Interventions: BEHAVIORAL: Psychosocial educational, support group and implementation of strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Daratumumab in Combination With Ixazomib and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Daratumumab, Ixazomib, Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Partial Rotator Cuff Repair vs. Superior Capsular Reconstruction for Irreparable Rotator Cuff Tears
Status: RECRUITING
Conditions: Rotator Cuff Tears
Interventions: PROCEDURE: Superior Capusular Reconstruction|PROCEDURE: Partial Rotator Cuff Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Replacement GH Therapy After Bariatric Surgery in Patients With Very Severe Obesity
Status: COMPLETED
Conditions: Obesity|GHD
Interventions: DRUG: Recombinant GH Saizen (Merck-Serono)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multidisciplinary Telerehabilitation Practices in Autism
Status: RECRUITING
Conditions: Physiotherapy and Rehabilitation|Nutrition|Autism Spectrum Disorder|Telerehabilitation
Interventions: OTHER: telerehabilitation exercise|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Psychiatric Disorders During Pregnancy at 2nd Trimester Ultrasound: a Feasibility Study in the General Population
Status: RECRUITING
Conditions: Pregnancy
Interventions: DIAGNOSTIC_TEST: standardized clinical psychiatric evaluations|DIAGNOSTIC_TEST: self-administered psychiatric questionnaire assessments|OTHER: blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Specialized Treatment Early in Psychosis (STEP)
Status: COMPLETED
Conditions: Schizophrenia and Disorders With Psychotic Features
Interventions: BEHAVIORAL: Cognitive Behavioral Group Therapy|BEHAVIORAL: Cognitive remediation|DRUG: Medications|BEHAVIORAL: MFG|BEHAVIORAL: Assertive case management|OTHER: Treatment as Usual in the community
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study to Investigate the Bioactivity, Ocular and Systemic Safety, Tolerability, and Pharmacokinetics Following Single and Multiple Intravitreal Administrations of KSI-301 in Subjects With wAMD, DME and RVO
Status: TERMINATED
Conditions: Wet Age-related Macular Degeneration|Retinal Vein Occlusion|Diabetic Macular Edema
Interventions: DRUG: KSI-301
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Starter Infant Formula With Synbiotics
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Infants
Interventions: OTHER: Control 1st age starter infant formula|OTHER: Experimental 1st age starter infant formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Assessment of Corneal Stiffness in Keratoconus After Crosslinking by Corvis ST and OCT.
Status: UNKNOWN
Conditions: Keratoconus
Interventions: DEVICE: Corvis ST (dynamic Scheimpflug technology)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Postoperative Analgesic Benefit of iPACK Block in the Anterior Cruciate Ligament Reconstruction Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Anesthesia|Anterior Cruciate Ligament Reconstruction
Interventions: PROCEDURE: adductor canal block|PROCEDURE: iPACK block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Use of Rectal Dialysis Technique to Measure Rectal 5-ASA Levels in Healthy Volunteers Receiving Asacol
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: PROCEDURE: Rectal dialysis|DRUG: Rectal dialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Use of Thalidomide, Lenalidomide, Carfilzomib, Bortezomib and Vorinostat in the Initial Treatment of Newly Diagnosed Multiple Myeloma Patients
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Induction (intensive pathway) - cyclophosphamide, lenalidomide, & dexamethasone (CRD) regimen|DRUG: Induction (intensive pathway) - cyclophosphamide, thalidomide, & dexamethasone (CTD) regimen|DRUG: Induction (intensive pathway) - carfilzomib, cyclophosphamide, lenalidomide, & dexamethasone (CCRD) regimen|DRUG: Induction (non-intensive pathway) - cyclophosphamide, lenalidomide, & dexamethasone attenuated (CRDa) regimen|DRUG: Induction (non-intensive pathway) - cyclophosphamide, thalidomide, & dexamethasone attenuated (CTDa) regimen|DRUG: Consolidation (intensive & non-intensive pathways) - bortezomib, cyclophosphamide, & dexamethasone (VCD) regimen|DRUG: Maintenance (intensive & non-intensive pathways) - lenalidomide maintenance|DRUG: Maintenance (intensive & non-intensive pathways - protocol v5.0 only) - lenalidomide plus vorinostat maintenance|DRUG: High dose melphalan therapy and autologous stem cell transplant (intensive pathway only)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV
Status: COMPLETED
Conditions: Peripheral Arterial Occlusive Disease
Interventions: DRUG: Alprostadil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Carpel Tunnel Syndrome and Physical Therapy Modalities
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: DEVICE: pulsed electromagnetic field|DEVICE: Therapeutic ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Talabostat and Cisplatin in Advanced Melanoma
Status: COMPLETED
Conditions: Melanoma|Skin Cancer
Interventions: DRUG: talabostat (PT-100) tablets|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnosis and Treatment of Co-infection With Human Immunodeficiency Virus /Latent Tuberculosis Infection (HIV/TBL)
Status: UNKNOWN
Conditions: Human Immunodeficiency Virus (HIV)|Tuberculosis (TB)|Latent Tuberculosis Infection (LTI)
Interventions: DRUG: Isoniazid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Using an iPhone ECG to Monitor the QT Interval on Dofetilide and Sotalol Patients
Status: COMPLETED
Conditions: Cardiac Arrhythmia|Qt Interval, Variation in
Interventions: DEVICE: iPhone ECG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Craniosacral Therapy in Patients With Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain|Musculoskeletal Manipulations
Interventions: OTHER: Craniosacral therapy|OTHER: Classic Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Shock Wave Therapy in Individuals With Lateral Epicondylitis
Status: COMPLETED
Conditions: Lateral Epicondylitis
Interventions: DEVICE: Extracorporeal shock wave therapy|OTHER: Conventional physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate Safety and Efficacy of Alveo HP Balloon Dilatation Catheter for Balloon Dilatation of Coronary Artery Stenosis
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Alveo HP Balloon Dilatation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMM 0212: Busulfan With Fludarabine and Antithymocyte Globulin as Preparative Therapy for Hematopoietic Stem Cell Transplant for the Treatment of Severe Congenital T-Cell Immunodeficiency
Status: COMPLETED
Conditions: T-Cell Immune Deficiency Diseases|Severe Combined Immunodeficiency
Interventions: DRUG: Busulfan, Fludarabine and ATG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Molecular Pathways Involved in Knee Pain
Status: COMPLETED
Conditions: Knee Osteoarthritis|Knee Pain Chronic
Interventions: DIAGNOSTIC_TEST: Quantitative Sensory Testing|RADIATION: Radiographic Evaluation|PROCEDURE: Ultrasound-guided Aspiration|DIAGNOSTIC_TEST: Muscle Strength Assessment|DIAGNOSTIC_TEST: Function Assessment (A)|DIAGNOSTIC_TEST: Function Assessment (B)|DIAGNOSTIC_TEST: Balance Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of EVT 302 With or Without NRT on Craving and Withdrawal in Healthy Male Smokers Deprived of Cigarettes
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: EVT 302, 10 mg|DRUG: placebo|DRUG: Nicotine replacement therapy (NRT)|DEVICE: NRT placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About the ARV-471 (PF-07850327) in People With ER+/HER2- Locally Advanced or Metastatic Breast Cancer (BC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Neoplasms
Interventions: DRUG: ARV-471
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ambulatory Infusions of Lidocaine and Ketamine for Management of Chronic Pain
Status: COMPLETED
Conditions: Chronic Neuropathic Pain and Fibromyalgia
Interventions: DRUG: Lidocaine Hydrochloride 2% Intravenous Solution, DIN 02421992
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Bi-manual Activities in Stroke Patients With Application of Neuro-stimulation
Status: SUSPENDED
Conditions: Stroke|Deficit in Manual Activities
Interventions: DEVICE: tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ischemic Preconditioning to Prevent Acute Kidney Injury
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: OTHER: Ischemic preconditionin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: 1/2- Bangladesh Center for Global Environmental and Occupational Health- Bangladesh
Status: RECRUITING
Conditions: Air Pollution|mHealth Intervention|Cardiopulmonary Function|Immune Function
Interventions: BEHAVIORAL: mHealth based behavioral change communication intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Matching Adults to Treatments for Chronic Pain (MATCH) Study
Status: RECRUITING
Conditions: Chronic Pain
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy (CBT)|BEHAVIORAL: Hypnotic Cognitive Therapy (HYP-CT)|BEHAVIORAL: Mindfulness-Based Cognitive Therapy (MBCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Oxygen Reserve Index in One-Lung Ventilation During Elective Thoracic Operations
Status: COMPLETED
Conditions: One-Lung Ventilation|Hypoxemia During Surgery|Oxygen Reserve Index|Perfusion Index|Pleth Variability Index
Interventions: DEVICE: Masimo Radical-7 Pulse CO-Oximeter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Smoking Cessation for Young Adults Who Binge Drink - 1
Status: COMPLETED
Conditions: Adherence|Tobacco Use Cessation|Alcohol & Drug Use|Nicotine Transdermal System
Interventions: BEHAVIORAL: Lifestyle counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study to Evaluate the Safety and Toxicity of the Combination of Zidovudine and 2',3'-Dideoxyinosine (Didanosine) in Children With HIV Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zidovudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Transaxillary Endoscopic and Open Thyroidectomy for PTC
Status: RECRUITING
Conditions: Papillary Thyroid Cancer
Interventions: PROCEDURE: GTPET(Gasless Transaxillary Posterial Endoscopic Thyroidectomy)|PROCEDURE: COT(Conventional Open Thyroidectomy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Acceptability of Availing Skilled Birth Attendance (SBA) Services Through Community Reproductive Health Nurses (CORN) to a Household Level at Rural Communities of Ethiopia; A Cluster Community Trial in Gedeo Zone, SNNPR
Status: COMPLETED
Conditions: Maternal Care Patterns
Interventions: PROCEDURE: trained midwives and nurses working in the community to provide skilled SBA services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Early Screening of Colorectal Cancer Based on Plasma Multi-omics Combining With Artificial Intelligence
Status: RECRUITING
Conditions: Colorectal Adenoma|Colorectal Cancer
Interventions: DIAGNOSTIC_TEST: Colonoscopy|DIAGNOSTIC_TEST: Test of ctDNA methylation|DIAGNOSTIC_TEST: Test of characteristics of ctDNA fragment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tracheostomy With Bedside Simultaneous Gastrostomy Vs Usual Care Tracheostomy And Delayed Gastrostomy Placement
Status: WITHDRAWN
Conditions: Stroke, Acute|TBI|Neuromuscular Diseases|Status Epilepticus|Coma|Cerebrovascular Disorders|Spinal Cord Injuries|Neurological Injury|Neurologic Injury
Interventions: OTHER: Timing of placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Davos Alzheimer's Collaborative Healthcare System Preparedness to Increase Cognitive Assessment Rates for Older Adults
Status: RECRUITING
Conditions: Subjective Cognitive Decline|Alzheimer Dementia
Interventions: DIAGNOSTIC_TEST: Cognigram|DIAGNOSTIC_TEST: Subjective cognitive decline questionnaire (SCD-Q)|DIAGNOSTIC_TEST: blood-based biomarkers|DIAGNOSTIC_TEST: ki:elements digital speech biomarker for cognition (ki:e SB-C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Use of Water Warming/Cooling Garment to Maintain a Constant Intraoperative Core Target Temperature in Patients Undergoing Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy (HIPEC): A Proof-of-Concept Study
Status: WITHDRAWN
Conditions: Hyperthermic Intraperitoneal
Interventions: DEVICE: Allon System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Third Party Viral Specific T-cells (VSTs)
Status: RECRUITING
Conditions: Viral Infection|Viral Reactivation|Infection in an Immunocompromised Host
Interventions: BIOLOGICAL: Viral Specific VST Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Venetoclax in Combination With Carfilzomib and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma (MM)
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Carfilzomib|DRUG: Venetoclax|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Insulin Resistance and Metformin Use on Volume of Benign Thyroid Nodules
Status: COMPLETED
Conditions: Thyroid Nodule|Insulin Resistance
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Photobiomodulation in a Partial Thickness Autogenous Skin Graft Donor Area
Status: COMPLETED
Conditions: Healing Wound
Interventions: RADIATION: Membracel and LED photobiomodulation|OTHER: Membracel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open Label Study of LMI070 (Branaplam) in Type 1 Spinal Muscular Atrophy (SMA)
Status: COMPLETED
Conditions: Spinal Muscular Atrophy
Interventions: DRUG: branaplam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes in Narcolepsy and Cataplexy: An Evaluation of Reboxetine Treatment (CONCERT)
Status: COMPLETED
Conditions: Narcolepsy|Cataplexy Narcolepsy|Excessive Sleepiness
Interventions: DRUG: AXS-12 (Reboxetine)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Corticosteroid Sparing Effect of Certolizumab in Crohn's Disease
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: certolizumab pegol 400 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Immulina TM Supplements With PASC Patients
Status: RECRUITING
Conditions: Post Acute COVID-19 Syndrome
Interventions: DIETARY_SUPPLEMENT: Immulina TM|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Physical Exercise Program in Chronic Chagas Heart Disease
Status: COMPLETED
Conditions: Chagas Disease|Chagas Cardiomyopathy
Interventions: BEHAVIORAL: Exercise, nutritional and pharmaceutical counceling|BEHAVIORAL: Nutritional and pharmaceutical counceling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of IntraNasal Insulin in Regulating HepaTic Lipid COntent in HUMANS
Status: UNKNOWN
Conditions: Healthy Subjects
Interventions: DRUG: Intranasal insulin administration|DRUG: Insulin Dilution Buffer (Novo Nordisk)|OTHER: 1H magnetic resonance spectroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 2 Study to Evaluate RPT193 in Adults With Moderate to Severe T2-high Asthma
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: RPT193|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study in de Novo Renal Transplantation
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: BIOLOGICAL: TCD601|DRUG: Tacrolimus (TAC)|DRUG: Corticosteroids (CS)|DRUG: Mycophenolate Mofetil (MMF)|DRUG: ATG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Insomnia Treatment and Problems (the iTAP Study)
Status: COMPLETED
Conditions: Insomnia|Alcohol; Harmful Use
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia (CBT-I)|BEHAVIORAL: Sleep Hygiene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pediatric Integrative Medicine Trial Pilot
Status: COMPLETED
Conditions: Pain|Nausea|Vomiting|Anxiety
Interventions: PROCEDURE: PIM consult and service provision|PROCEDURE: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Validation of a Miniature SpO2 Sensor in Healthy Subjects and Patients With Long-term Oxygen Therapy.
Status: COMPLETED
Conditions: Pulse Oximeter Validation|Long Term Oxygen Therapy|Hypoxemia
Interventions: DEVICE: OxyFrame
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Family-based and Adolescent Residential Drug Treatment
Status: COMPLETED
Conditions: Substance Use|Delinquency
Interventions: BEHAVIORAL: Multidimensional Family Therapy (MDFT)|BEHAVIORAL: Adolescent Residential Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating DS-1055a in Participants With Relapsed or Refractory Locally Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor|Advanced Cancer|Metastatic Solid Tumor
Interventions: DRUG: DS-1055a
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of the Rate of Force Application in Responses to Spinal Manipulation Therapy
Status: COMPLETED
Conditions: Spinal Manipulation
Interventions: PROCEDURE: Spinal manipulation|DEVICE: Apparatus used to deliver spinal manipulations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Effectiveness and Safety of Risperidone Compared With Haloperidol and Placebo in Patients With Chronic Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders
Interventions: DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Single Group Study to Evaluate the Effects of a Myo-Inositol and D-Chiro Inositol Supplement on Symptoms Associated With Polycystic Ovary Syndrome and Hormone Imbalance
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Hormone Imbalance
Interventions: DIETARY_SUPPLEMENT: Optify Myo Inositol and D-Chiro Inositol Plus Folate and Vitamin D supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Administration of Expanded Autologous Adult Bone Marrow Mesenchymal Cells in Established Chronic Spinal Cord Injuries
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: BIOLOGICAL: Autologous Mesenchymal Bone Marrow Cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study of LY3209590 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3209590 (SC)|DRUG: LY3209590 (IV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate-to-severe COPD With Type 2 Inflammation
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Dupilumab SAR231893|DRUG: Inhaled Corticosteroid|DRUG: Inhaled Long-Acting Beta Agonist|DRUG: Inhaled Long-Acting Muscarinic Antagonist|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing a Primary Care Model for the Treatment of Opioid Dependence Using Long-acting Injectable Naltrexone (Vivitrol).
Status: WITHDRAWN
Conditions: Drug Dependence
Interventions: BEHAVIORAL: Primary Care Counseling|BEHAVIORAL: Cognitive-behavioral psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Alternative Quadrivalent Human Papilloma Virus (HPV) Vaccination Schedules in a University Setting
Status: COMPLETED
Conditions: Human Papillomavirus Infection
Interventions: BIOLOGICAL: Quadrivalent human papillomavirus vaccine on-time administration|BIOLOGICAL: Quadrivalent human papillomavirus vaccine delayed administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: NPI-002 Intravitreal Implant for the Delay of Cataract Progression
Status: RECRUITING
Conditions: Cataract
Interventions: DRUG: NPI-002 Intravitreal Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Lira Pump Trial
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Liraglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aerosolized Beta-Agonist Isomers in Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: levalbuterol|DRUG: saline|OTHER: levalbuterol MDI|DEVICE: breath actuated nebulizer|DEVICE: aerochamber max|DRUG: ipratroprium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antibiotic Treatment in Ventilator Associated Tracheobronchitis (VAT)
Status: UNKNOWN
Conditions: Tracheobronchitis
Interventions: DRUG: Piperacillin/Tazobactam for 7 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retrospectively Analyze the Risk Factors of VTE in 5774 Patients With Thoracic Trauma From 33 Hospitals in China, and Established a Risk Prediction Model
Status: COMPLETED
Conditions: Thorax Injuries|Embolism Vein|Embolism, Pulmonary|Rib Fractures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Atezolizumab and Bevacizumab Before Surgery for the Treatment of Resectable Liver Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Resectable Hepatocellular Carcinoma|Stage I Hepatocellular Carcinoma AJCC V8|Stage IA Hepatocellular Carcinoma AJCC V8|Stage IB Hepatocellular Carcinoma AJCC V8|Stage II Hepatocellular Carcinoma AJCC V8
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of the Combination of Loop With Thiazide-type Diuretics in Patients With Decompensated Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: hydrochlorothiazide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Use of Ultrasound for Greater Palatine Nerve Block and Inferior Alveolar Nerve Blocks: An Open Label Feasibility Study
Status: UNKNOWN
Conditions: Greater Palatine Nerve Block|Inferior Alveolar Nerve Block
Interventions: PROCEDURE: US guided block
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Trial of Obinutuzumab and CC-99282 for Patients With Previously Untreated High Tumor Burden Follicular Lymphoma
Status: RECRUITING
Conditions: Follicular Lymphoma|Tumor
Interventions: DRUG: Obinutuzumab|DRUG: CC-99282
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant SARS-CoV-2 Fusion Protein Vaccine (V-01) Booster Study
Status: COMPLETED
Conditions: COVID-19 Pandemic
Interventions: BIOLOGICAL: Recombinant SARS-CoV-2 Fusion Protein Vaccine (V-01)|BIOLOGICAL: Blank Preparation of Recombinant SARS-CoV-2 Fusion Protein Vaccine (V-01)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Busulfan, Melphalan, and Bortezomib Before First-Line Stem Cell Transplant in Treating Patients With Multiple Myeloma
Status: COMPLETED
Conditions: DS Stage I Plasma Cell Myeloma|DS Stage II Plasma Cell Myeloma|DS Stage III Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: DRUG: Busulfan|DRUG: Melphalan|DRUG: Bortezomib|PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation|PROCEDURE: Peripheral Blood Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venetoclax Added to Fludarabine + Busulfan Prior to Transplant and to Maintenance Therapy for AML, MDS, and MDS/MPN
Status: RECRUITING
Conditions: Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome (MDS)|Chronic Myelomonocytic Leukemia (CMML)|MDS/Myeloproliferative Neoplasm-unclassifiable (MDS/MPN-unclassifiable)|Hematopoietic Stem Cell Transplant
Interventions: DRUG: Venetoclax|DRUG: Fludarabine|DRUG: Busulfan|DRUG: Venetoclax|DRUG: Azacitidine|DRUG: Decitabine/cedazuridine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Health Professional Impact Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronavirus Infection|Severe Acute Respiratory Syndrome
Interventions: OTHER: Survey|DIAGNOSTIC_TEST: SARS-CoV-2 antibody test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Tolerability of Different Dose Combinations of Ridaforolimus With MK-2206 or MK-0752 for Participants With Advanced Cancer (MK-8669-049)
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: DRUG: ridaforolimus|DRUG: MK-0752|DRUG: MK-2206
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Immune and Safety Response of GlaxoSmithKline (GSK) Biologicals' HPV Vaccine in Healthy Indian Women
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: HPV-16/18 VLP/AS04 Vaccine (Cervarix TM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Role of Huachansu in Treating Hepatocellular Carcinoma and the Correlation With Na+/K+-ATPase
Status: UNKNOWN
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Huachansu|OTHER: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remotely Supervised Computerized Cognitive Stimulation to Reduce Post-chemotherapy Cognitive Difficulties in Patients Treated for Localized Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Cognitive Dysfunction
Interventions: OTHER: Cognitive exercises with supervision|OTHER: Cognitive exercises without supervision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Tiotropium Bromide Alone vs Tiotropium Bromide and Formoterol Fumarate in Subjects With COPD (Study P04272)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: formoterol fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Puerto Rico Asthma Integrated Response Program ("PR-AIR")
Status: NOT_YET_RECRUITING
Conditions: Pediatric Asthma
Interventions: BEHAVIORAL: CASE in person version (High Intensity Package)|BEHAVIORAL: CASE-V remote version (Low Intensity Package)|BEHAVIORAL: CASE and HARP in person (High Intensity package)|BEHAVIORAL: CASE-V and HARP-V remote version (Low Intensity package)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-flux Hemodialysis Versus Hemodiafiltration for End-Stage Renal Disease
Status: UNKNOWN
Conditions: Chronic Kidney Failure
Interventions: OTHER: High-flux hemodialysis|OTHER: Hemodiafiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Disc Prosthesis Versus Multidisciplinary Rehabilitation
Status: COMPLETED
Conditions: Chronic Low Back Pain|Degenerative Disc Disease
Interventions: DEVICE: Total Disc Prosthesis|BEHAVIORAL: Multidisciplinary rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "Comparative Evaluation of 3 Dimensional Changes of Dentition in Post Orthodontic Patients With Immediate vs Delayed (Post 7 Days) Retainer Delivery
Status: RECRUITING
Conditions: Relapse
Interventions: OTHER: immediate orthodontic retainer delivery|OTHER: delayed orthodontic retainer delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Exercise Tolerance After Venous Recanalization for Post-thrombotic Syndrome
Status: RECRUITING
Conditions: Post Thrombotic Syndrome|Venous Thromboses|Claudication, Intermittent
Interventions: DIAGNOSTIC_TEST: Stress test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Trial to Compare and Evaluate the Safety and Pharmacokinetic After Oral Administration of CKD-341 and D956 in Healthy Adults
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: CKD-341, D956
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Lidocaine Sprayed for Attenuating Hemodynamic Response During Laryngoscopy and Intubation
Status: NOT_YET_RECRUITING
Conditions: Laryngoscopy|Intubation|Hemodynamics|Neurosurgery|Lidocaine
Interventions: DRUG: lidocaine spray|DRUG: Intravenous Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Efficacy and Safety of Grazoprevir/Elbasvir Associated With Sofosbuvir and Ribavirin in HCV Genotype 1 or 4-infected Patients Who Failed Direct Acting Antivirals (DAA) Bitherapy With Sofosbuvir
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Grazoprevir/Elbasvir|DRUG: Sofosbuvir|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Safety and Efficacy of INCB018424 in Patients With Polycythemia Vera or Essential Thrombocythemia
Status: TERMINATED
Conditions: Myeloproliferative Neoplasm (MPN)
Interventions: DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine With or Without Capecitabine in Treating Patients With Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Gemcitabine + Capecitabine|DRUG: Gemcitabine alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Parenting With Positive Interven on Comm Inclusion for Military Connected and Dependents With Autism
Status: COMPLETED
Conditions: Autism
Interventions: BEHAVIORAL: Parenting with Positive Behavior Interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Rectal Indomethacin as Early Treatment for Acute Pancreatitis (INDOMAP Trial)
Status: RECRUITING
Conditions: Acute Pancreatitis|Complication|Mortality Rate|Organ Failure, Multiple
Interventions: DRUG: Indomethacin SR|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Controlled Study of Steroids Therapy for Patients of IgA Nephropathy With Active Pathological Changes.
Status: UNKNOWN
Conditions: Glomerulonephritis, IGA|Peripapillary Crescent|Necrosis|Steroid Nephropathy
Interventions: DRUG: Methylprednisolone(intravenously in the 1st-2nd-3rd month )|DRUG: Methylprednisolone(intravenously in the 1st-3rd-5th month)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Usefulness of Video-Based Intervention in Helping Participants Encourage Their Families to Get Tested for BRCA Gene Mutations
Status: UNKNOWN
Conditions: BRCA1 Gene Mutation|BRCA2 Gene Mutation
Interventions: OTHER: Informational Intervention|OTHER: Informational Intervention|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Gut Microbiome and Blood Markers After Habitual Herbal Tea Consumption
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Well-being
Interventions: DIETARY_SUPPLEMENT: TeTrimTeas welsh Herbal tea with rhubarb root|DIETARY_SUPPLEMENT: TeTrimTeas welsh Herbal tea with senna|DIETARY_SUPPLEMENT: TeTrimTeas welsh Herbal tea with green tea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Dutch STRIDER (Sildenafil TheRapy In Dismal Prognosis Early-onset Fetal Growth Restriction)
Status: TERMINATED
Conditions: Fetal Growth Restriction
Interventions: DRUG: Sildenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nasotracheal Tube Stenting by Nelaton Catheter in Pediatric Dental Surgery
Status: COMPLETED
Conditions: Anesthesia Intubation Complication
Interventions: DEVICE: Endotracheal tube|DEVICE: Nelaton catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: "New Perspectives of Adaptation to NIV in ALS"
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis (ALS)
Interventions: OTHER: Adaptation and training to Non Invasive Ventilation (NIV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smoke Free SafeCare: Establishing a Smoke Free Home in CPS-involved Families
Status: RECRUITING
Conditions: Child Maltreatment|Smoking Behaviors
Interventions: BEHAVIORAL: Smoke Free SafeCare|BEHAVIORAL: Standard SafeCare
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Pea Flour in Bread on Blood Glucose
Status: COMPLETED
Conditions: Post-prandial Glycaemic Response
Interventions: DIETARY_SUPPLEMENT: Untreated|DIETARY_SUPPLEMENT: Heat treated with 0% moisture|DIETARY_SUPPLEMENT: Heat treated with 10% moisture|DIETARY_SUPPLEMENT: Wheat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of ACE-inhibitors on Aortic Stiffness in Elderly Patients With Chronic Kidney Disease
Status: COMPLETED
Conditions: Cardiovascular Disease|Chronic Kidney Disease
Interventions: DRUG: angiotensin converting enzyme inhibitor|DRUG: lisinopril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicentre Study of the Efficacy and Safety of Supplementary Treatment With Cholecalciferol in Patients With Relapsing Multiple Sclerosis Treated With Subcutaneous Interferon Beta-1a 44 µg 3 Times Weekly
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol (Vitamin D3)|DIETARY_SUPPLEMENT: Placebo|DRUG: Rebif
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intravitreal Aflibercept for Neovascular Polypoidal Choroidal Vasculopathy (RIVAL Trial)
Status: UNKNOWN
Conditions: Neovascular Polypoidal Choroidal Vasculopathy
Interventions: DRUG: Rescue Intravitreal Aflibercept Injection|PROCEDURE: Rescue Therapy with PDT, Laser or Intravitreal Steroids
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet-delivered Cognitive Behavior Therapy Compared to Stress Management for Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation|Arrythmia
Interventions: BEHAVIORAL: Internet-deliviered exposure-based CBT|BEHAVIORAL: Internet-delivered stress management treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Worldwide, Phase I, Dose-Escalating Study of a 3-Dose Regimen of the MRKAd5 (Clade B) Vaccine in Healthy Adults (V520-018)
Status: COMPLETED
Conditions: HIV-1|HIV Infections
Interventions: BIOLOGICAL: V520|BIOLOGICAL: Comparator: V520 (1x10^9 vp/d)|BIOLOGICAL: Comparator: V520 (1x10^10 vp/d)|BIOLOGICAL: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Rapid Study: Randomized Phase II Study To Expedite Allogeneic Transplant With Immediate Haploidentical Plus Unrelated Cord Donor Search Versus Matched Unrelated Donor Search For AML And High-Risk MDS Patients
Status: TERMINATED
Conditions: Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome (MDS)
Interventions: BIOLOGICAL: Haplo-Cord Transplant|PROCEDURE: Matched Unrelated Donor Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Intravenous Levosimendan in Ambulatory Advanced Chronic Heart Failure Patients
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Levosimendan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Research Study to Compare Two Doses of Semaglutide Taken Once Weekly in People With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide|DRUG: Placebo (semaglutide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Beamion PANTUMOR-1: A Study to Test Whether Zongertinib Helps People With Advanced Cancers With HER2 Alterations
Status: NOT_YET_RECRUITING
Conditions: Solid Tumours
Interventions: DRUG: Zongertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of Clazosentan in Reversing Cerebral Vasospasm in Adult Subjects With Aneurysmal Subarachnoid Hemorrhage
Status: COMPLETED
Conditions: Aneurysmal Subarachnoid Hemorrhage
Interventions: DRUG: Clazosentan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Versus Low Positive End Expiratory Pressure With Alveolar Recruitment Maneuver in Laparoscopic Bariatric Surgeries
Status: COMPLETED
Conditions: Anesthesia
Interventions: DEVICE: Recruitment with low PEEP|DEVICE: High PEEP without RM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE