pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Randomized Trial of a Quality Improvement Intervention to Decrease D2B Time in Primary PCI for AMI
Status: COMPLETED
Conditions: STEMI
Interventions: OTHER: Non Intervention|OTHER: Agressive Intervention Process Improvement Strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Implant Placement Using Open Sinus Elevation Technique With and Without Bone Grafting Material
Status: NOT_YET_RECRUITING
Conditions: Sinus Elevation
Interventions: PROCEDURE: Open sinus lifting without bone grafting and simultaneous implant placement|PROCEDURE: Open sinus lifting with bone grafting and simultaneous implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outcomes Associated With Application of a Normothermia Protocol in Patients With Severe Neurological Insult and Fever
Status: COMPLETED
Conditions: Subarachnoid Hemorrhage|Severe Traumatic Brain Injury
Interventions: OTHER: Stepwise normothermia protocol|DRUG: Ibuprofen|DRUG: Acetominophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Heat Application on the Delivery Profile of Corplex™ Donepezil Transdermal Delivery System (TDS)
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Donepezil TDS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid Acting TMS for Suicide Ideation in Depression
Status: RECRUITING
Conditions: Depressive Disorder, Major|Suicide
Interventions: DEVICE: Accelerated Theta Burst Stimulation|DEVICE: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Scotchbond Universal Plus Compared to Scotchbond Universal for Posterior Class I & II Restorations With Filtek Universal
Status: ACTIVE_NOT_RECRUITING
Conditions: Cavities of Teeth|Dental Decay
Interventions: DEVICE: Scotchbond™ Universal Plus Adhesive|DEVICE: Scotchbond™ Universal Adhesive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Melodica Orchestra for Dyspnea: Safety and Feasibility Pilot
Status: WITHDRAWN
Conditions: COPD|Chronic Obstructive Pulmonary Disease|Dyspnea|Breathlessness|Emphysema|Chronic Bronchitis
Interventions: BEHAVIORAL: Melodica Intervention|BEHAVIORAL: Pulmonary Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanistic Studies of Nicotinamide Riboside in Human Heart Failure
Status: RECRUITING
Conditions: Heart Failure, Systolic|Heart Failure NYHA Class IV|Metabolic Disturbance
Interventions: DRUG: Nicotinamide riboside|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Telematic Program for the Treatment of Depression in Type 1 Diabetes
Status: UNKNOWN
Conditions: Type 1 Diabetes Mellitus|Depression
Interventions: BEHAVIORAL: Treatment group (TG)|BEHAVIORAL: Control group (CG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Retrowalking Program Versus Whole Body Vibration in Patients With Chronic Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: routine physiotherapy program for knee osteoarthritis|OTHER: Retro-walking program|OTHER: whole body vibration training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comprehensive Yoga Therapy Based Lifestyle Prehabilitation Program for Women With Ovarian Cancer
Status: NOT_YET_RECRUITING
Conditions: Ovarian Cancer
Interventions: OTHER: Yoga Therapy for Nutritional, Physical, and Psychosocial Prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety Trial of Single Versus Multiple Dose Thymoglobulin Induction in Kidney Transplantation
Status: COMPLETED
Conditions: End-Stage Renal Disease|Kidney Failure
Interventions: BIOLOGICAL: Single-dose rabbit Anti-thymocyte Globulin induction|BIOLOGICAL: Divided-dose rabbit Anti-thymocyte Globulin induction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Dry Needling on the Superficial Neck Musculature
Status: COMPLETED
Conditions: Neck Pain
Interventions: OTHER: Dry needling|OTHER: Sham dry needling|OTHER: Electrotherapy + therapeutic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Versus Oral Iron for Treating Iron-Deficiency Anemia in Pregnancy
Status: RECRUITING
Conditions: Iron Deficiency Anemia|Pregnancy
Interventions: DRUG: Ferric derisomaltose|DRUG: Ferrous sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Exercise Capacity With Tailored Physical Activity in Lymphoma & Breast Cancer Patients Undergoing Tx
Status: COMPLETED
Conditions: Hodgkin Lymphoma|Non-hodgkin Lymphoma|Lymphoma|Breast Cancer
Interventions: OTHER: Physical Activity Intervention (PAI)|OTHER: Healthy Living Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Combination of Anti-PD-1 and NK Immunotherapy for Recurrent Solid Tumors
Status: COMPLETED
Conditions: Malignant Solid Tumour
Interventions: DRUG: Pembrolizumab|BIOLOGICAL: NK immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AZA Combined With NAC for PIT After HSCT
Status: NOT_YET_RECRUITING
Conditions: Thrombocytopenia, Isolated|Stem Cell Transplant Complications
Interventions: DRUG: Azacitidine|DRUG: N Acetyl L Cysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin E and Pentoxifylline in Treating Women With Lymphedema After Radiation Therapy for Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Lymphedema
Interventions: DIETARY_SUPPLEMENT: vitamin E|DRUG: pentoxifylline|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phosphodiesterase Type 5 Inhibition to Improve Endothelial Function and Vascular Remodeling in Chronic Kidney Disease and End Stage Renal Disease Patients Requiring New Arteriovenous Fistula
Status: COMPLETED
Conditions: Improve Endothelial Function and Decrease Vascular Stenosis
Interventions: DRUG: Sildenafil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Moxonidine in Patients Undergoing Vascular Surgery
Status: TERMINATED
Conditions: Cardiac Disease|Vascular Surgery
Interventions: DRUG: moxonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sexual Education in Women Based On The Plissit Model On Awareness And Attitude in Midwifery Students
Status: COMPLETED
Conditions: Cancer|Educational Problems|Sex Behavior
Interventions: OTHER: Education based on the PLISSIT model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Reversal of the Antiplatelet Effects of Ticagrelor in Combination With Aspirin, Using Normal Platelets
Status: UNKNOWN
Conditions: Ticagrelor|Aspirin|Platelet Dysfunction Due to Drugs|Transfusion
Interventions: DRUG: Antiplatelet treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Using HYADERMIS LA for Wrinkle Correction
Status: COMPLETED
Conditions: Pain|Nosalabial Folds Correction
Interventions: DEVICE: lidocaine contained hyaluronate facial dermal filler|DEVICE: hyaluronate facial dermal filler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Prospective Evaluation of Peri-Operative Glucocorticoid Use in the Management of Cervicofacial Infections of Odontogenic Origin
Status: COMPLETED
Conditions: Odontogenic Infection of Jaw (Disorder)
Interventions: DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Effects of DPP-4 Inhibitor Linagliptin in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Linagliptin 5 mg QD (N=24)|DRUG: Glimepiride 1 mg QD (N=24)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Glyaderm + Split Thickness Skin Graft Versus Split Thickness Skin Graft Alone in Full Thickness Skin Defects
Status: COMPLETED
Conditions: Full Thickness Skin Defects
Interventions: PROCEDURE: Glyaderm and split skin graft|PROCEDURE: Split skin graft alone.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of DSA on Recovery of Anaesthesia in Children (Het Effect Van DSA op Het Herstel na Anesthesie Bij Kinderen).
Status: RECRUITING
Conditions: Anesthesia|Depth of Hypnosis Monitoring
Interventions: DEVICE: Narcotrend Monitor (MT MonitorTechnik, Hannover, Germany)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Metabolic Effects of Cynara Supplementation in Overweight and Obese Class I Subjects With Newly Detected Impaired Fasting Glycaemia.
Status: COMPLETED
Conditions: Insulin Sensitivity|Obesity|Overweight
Interventions: DIETARY_SUPPLEMENT: 500 mg of artichoke extract|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Lidocaine and Xylometazoline Intranasal Spray in Anesthetizing Maxillary Teeth
Status: COMPLETED
Conditions: Effect of Drug
Interventions: DRUG: Lidocaine topical|DRUG: Lidocaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Treatments for the Prevention of Radiotherapy-Induced Mucositis
Status: COMPLETED
Conditions: Radiotherapy Side Effect|Mucositis
Interventions: DRUG: MEBO ointment|DRUG: Symptomatic treatment only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Pain Levels in Fusion Prostate Biopsy and Standard TRUS-Guided Biopsy
Status: COMPLETED
Conditions: Pain Due to Certain Specified Procedures|Prostate Cancer|Biopsy
Interventions: PROCEDURE: Standard transrectal 12 core biopsy|PROCEDURE: MRI- US fusion prostate biopsy (FPB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Tolerance Study of Three Probiotic Strains in Infants
Status: COMPLETED
Conditions: Body Weight|Body Height|Head Circumference
Interventions: DIETARY_SUPPLEMENT: Bifidobacterium longum ssp infantis R0033|DIETARY_SUPPLEMENT: Lactobacillus helveticus R0052|DIETARY_SUPPLEMENT: Bifidobacterium bifidum R0071|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Multiple-dose Tolerability and Pharmacokinetic of IBI362 in Chinese Patients With T2DM
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: IBI362|DRUG: Placebo|DRUG: Dulaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: E7050 in Combination With Sorafenib Versus Sorafenib Alone as First Line Therapy in Participants With Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Sorafenib|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Valsartan to Prevent Left Ventricle Remodeling in Pacemaker Patients
Status: TERMINATED
Conditions: First Time Dual Chamber Pacemaker Implantation
Interventions: DRUG: placebo/valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Sirolimus in Combination With MEC in High Risk Myeloid Leukemias
Status: COMPLETED
Conditions: Myeloid Leukemias|AML|Leukemia|CML
Interventions: DRUG: Rapamycin, Mitoxantrone, Etoposide, Cytarabine|DRUG: Rapamycin + MEC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Non-invasive Index of Microciculatory Resistance
Status: RECRUITING
Conditions: Coronary Microvascular Disease|Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: CCTA, CT-MPI, DSA, FFR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Brinzolamide/Brimonidine Twice a Day (BID) Fixed Combination (FC) vs Brinzolamide BID Plus Brimonidine BID in Patients With Open Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Brinzolamide 1%/brimonidine tartrate 0.2% fixed combination ophthalmic suspension|DRUG: Vehicle|DRUG: Brinzolamide 1% ophthalmic suspension|DRUG: Brimonidine tartrate 0.2% ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Decision Aids in Urogynecology
Status: COMPLETED
Conditions: Pelvic Organ Prolapse|Stress Urinary Incontinence|Overactive Bladder
Interventions: BEHAVIORAL: Pelvic organ prolapse decision aid|BEHAVIORAL: Stress urinary incontinence decision aid|BEHAVIORAL: Overactive bladder decision aid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Repetitive Transcranial Magnetic Stimulation Compared or Associated With Venlafaxine for Depressive Disorder
Status: UNKNOWN
Conditions: Depression
Interventions: OTHER: active rTMS and active Venlafaxine|OTHER: active rTMS and sham Venlafaxine|OTHER: sham rTMS and active Venlafaxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Assess the Patients' Ability to Self-Administer Fasinumab
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Osteoarthritis, Hip
Interventions: DRUG: Fasinumab AI|DRUG: Fasinumab PFS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gene-based Personalised Diet and Physical Activity Advice on Adiposity Indices Personalised Diet and Physical Activity Advice on Adiposity Indices in University Students
Status: UNKNOWN
Conditions: Adiposity|Behavior, Health
Interventions: GENETIC: Genotype- based personalised advice|BEHAVIORAL: Non genetic personalised advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of Trachway (R) Intubating Stylet in the Insertion of the Double Lumen Endobronchial Tube
Status: COMPLETED
Conditions: Anesthesia Intubation Complications
Interventions: DEVICE: Direct laryngoscope (Macintoish laryngoscope)|DEVICE: Trachway(R) intubating stylet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of Two Bulk-Fill Composite of Posterior Restorations
Status: COMPLETED
Conditions: Post Dental Restoration|Caries, Dental
Interventions: DEVICE: Filtek Bulk Fill Composite and Tetric N Ceram Bulk Fill Composite|DEVICE: Z 350 Xt Composite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotic Beer to Enhance Gut Health and Immune System Function
Status: COMPLETED
Conditions: Inflammation|Nutrition, Healthy
Interventions: DIETARY_SUPPLEMENT: Moderate probiotic beer consumption|DIETARY_SUPPLEMENT: Moderate normal beer consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study in Men With Prostate Cancer to Assess the Safety, Pharmacokinetics and Testosterone-Lowering Efficacy of TAK-448
Status: TERMINATED
Conditions: Prostate Cancer|Prostatic Neoplasms
Interventions: DRUG: Leuprorelin|DRUG: TAK-448
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficacy and Safety Between Imidafenacin and Fesoterodine in Patients With Overactive Bladder
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: Imidafenacin|DRUG: Fesoterodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Distal Radius Fracture Repair
Status: RECRUITING
Conditions: Distal Radius Fractures
Interventions: DRUG: Liposomal bupivacaine|DRUG: Bupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of BA058 (Abaloparatide) for Prevention of Fracture in Postmenopausal Women
Status: COMPLETED
Conditions: Osteoporosis|Postmenopausal Osteoporosis
Interventions: DRUG: Placebo|DRUG: BA058 80 mcg|DRUG: teriparatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HeartGPS: A Study Exploring the Effects of a Psychological Intervention for Parents and Their Babies After Prenatal Cardiac Diagnosis
Status: NOT_YET_RECRUITING
Conditions: Heart Defects, Congenital|Anxiety in Pregnancy|Depression, Postpartum|Trauma, Psychological|Neurodevelopmental Disorders
Interventions: BEHAVIORAL: HeartGPS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Total Laparoscopic Hysterectomy Versus Total Abdominal Hysterectomy in Women With Endometrial Neoplasia
Status: COMPLETED
Conditions: Hysterectomy|Laparoscopy
Interventions: PROCEDURE: Hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Erdosteine in Chronic Obstructive Pulmonary Disease (COPD)
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Erdosteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Aleglitazar in Combination With Aspirin in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: aleglitazar|DRUG: aspirin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy and Safety of Broncho-munal®, Capsules, 7 mg for the Treatment of Acute Uncomplicated Respiratory Tract Infections
Status: COMPLETED
Conditions: Acute Uncomplicated Respiratory Tract Infections
Interventions: DRUG: Broncho-munal®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Immune Response of IMVAMUNE (MVA-BN)Smallpox Vaccine in HIV Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: IMVAMUNE (MVA-BN)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safinamide Steady State Interaction With Rosuvastatin
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 100 mg safinamide|DRUG: 20 mg rosuvastatin calcium period 1|DRUG: 20 mg rosuvastatin calcium period 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Autonomic Co-regulation Between Newborn and Parent During Kangaroo Care Sessions in Neonatal Intensive Care Units
Status: COMPLETED
Conditions: Newborn
Interventions: DEVICE: Evaluation of Autonomic nervous system indices
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Chronic Nitrate Supplementation on Acute Mountain Sickness and Exercise Performance in Hypoxia
Status: COMPLETED
Conditions: Hypoxia
Interventions: DIETARY_SUPPLEMENT: Beetroot Juice|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of Mouth|Intraepithelial Neoplasia
Interventions: DRUG: 10% FBR containing bioadhesive gel|DRUG: placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety of Bilateral HTO: One-Stage vs.Two-Stage: A Randomized Controlled Study
Status: COMPLETED
Conditions: Gonarthrosis; Primary|Varus Gonarthrosis
Interventions: PROCEDURE: simultaneous bilateral high tibial osteotomy|PROCEDURE: Staged bilateral high tibial osteotomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Whole-Course Multidisciplinary Care Intervention on Patients With Head and Neck Carcinoma
Status: COMPLETED
Conditions: Head and Neck Carcinoma
Interventions: BEHAVIORAL: Whole-Course Multidisciplinary Care Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lapatinib in Combination With Trastuzumab in Patients With HER2-Positive, Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Lapatinib|DRUG: Herceptin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Utility of Syringe Based Suction Versus Channel Suction in Bronchoalveolar Lavage
Status: COMPLETED
Conditions: Bronchoscopy
Interventions: PROCEDURE: Bronchoscopy/ BAL with Channel Suction|PROCEDURE: Bronchoscopy/BAL with Syringe Suction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: FOcal Radiation for Oligometastatic Castration-rEsistant Prostate Cancer (FORCE)
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: RADIATION: Ablative Radiation Therapy|DRUG: Hormone therapy or chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lucentis to Treat Retinopathy of Prematurity (ROP) 3 Plus Disease
Status: COMPLETED
Conditions: Retinopathy of Prematurity
Interventions: DRUG: intravitreal injection of 0.03ml ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Reformer Pilates Exercise Improve Cognitive Functions in Sedentary Women?
Status: NOT_YET_RECRUITING
Conditions: Reformer Pilates Exercise, Cognitive Performans
Interventions: OTHER: Reformer pilates exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trial of Lapatinib Versus Lapatinib With Capecitabine in Her2+ Metastatic Gastro-Esophageal Cancer
Status: TERMINATED
Conditions: GastroEsophageal Cancer
Interventions: DRUG: Lapatinib|DRUG: Lapatinib plus capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Gemcitabine/Cisplatin + PF-3512676 vs Gemcitabine/Cisplatin Alone in Patients With Advanced NSCLC
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Cisplatin|DRUG: Gemcitabine|DRUG: PF-3512676|DRUG: Cisplatin|DRUG: Gemcitabine + Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study to Investigate SER120 Nasal Spray Formulations in Patients With Nocturia - DB4
Status: COMPLETED
Conditions: Nocturia
Interventions: DRUG: SER120 750 ng|DRUG: SER120 1500 ng|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study Conducted in Multiple Centers Comparing Veliparib in Combination With Carboplatin and Paclitaxel Versus a Placebo in Combination With Carboplatin and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small -Cell Lung Cancer
Interventions: DRUG: Veliparib|DRUG: Carboplatin|DRUG: paclitaxel|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Radiotherapy (SBRT) for Medically Inoperable Localised Renal Tumors (SABINA Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Kidney Neoplasm|Renal Cancer|Inoperable Disease|SBRT|SABR
Interventions: RADIATION: SBRT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized Trial of Internet Access to Nicotine Patches
Status: COMPLETED
Conditions: Smoking Cessation|Tobacco Use Disorder
Interventions: DRUG: Nicotine patches|BEHAVIORAL: Telephone counseling|BEHAVIORAL: iQuit Smoking website
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Intravenous Anidulafungin as a Treatment for Azole-Refractory Mucosal Candidiasis (FRMC)
Status: COMPLETED
Conditions: Candidiasis
Interventions: DRUG: Anidulafungin, VER002
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pazopanib, Lapatinib or Trastuzumab in Subjects With Solid Tumors
Status: COMPLETED
Conditions: Advanced Cancers
Interventions: DRUG: Pazopanib|DRUG: Lapatinib|DRUG: Trastuzumab (Herceptin®)|DRUG: Pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrapleural Photodynamic Therapy in a Multimodal Treatment for Patients With Malignant Pleural Mesothelioma
Status: COMPLETED
Conditions: Malignant Pleural Mesothelioma
Interventions: DEVICE: photodynamic therapy (PDT)|PROCEDURE: thoracic surgery Pleurectomy / extended Decortication|DRUG: Adjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab for the Treatment of Patients With Metastatic Urothelial Cancer With ARID1A Mutation and Stratify Response Based on CXCL13 Expression
Status: RECRUITING
Conditions: Locally Advanced Bladder Urothelial Carcinoma|Locally Advanced Renal Pelvis Urothelial Carcinoma|Locally Advanced Ureter Urothelial Carcinoma|Locally Advanced Urethral Urothelial Carcinoma|Locally Advanced Urothelial Carcinoma|Metastatic Bladder Urothelial Carcinoma|Metastatic Renal Pelvis Urothelial Carcinoma|Metastatic Ureter Urothelial Carcinoma|Metastatic Urethral Urothelial Carcinoma|Metastatic Urothelial Carcinoma|Recurrent Bladder Urothelial Carcinoma|Recurrent Renal Pelvis Urothelial Carcinoma|Recurrent Ureter Urothelial Carcinoma|Recurrent Urethral Urothelial Carcinoma|Recurrent Urothelial Carcinoma|Stage III Bladder Cancer AJCC v8|Stage III Renal Pelvis Cancer AJCC v8|Stage III Ureter Cancer AJCC v8|Stage III Urethral Cancer AJCC v8|Stage IIIA Bladder Cancer AJCC v8|Stage IIIB Bladder Cancer AJCC v8|Stage IV Bladder Cancer AJCC v8|Stage IV Renal Pelvis Cancer AJCC v8|Stage IV Ureter Cancer AJCC v8|Stage IV Urethral Cancer AJCC v8|Stage IVA Bladder Cancer AJCC v8|Stage IVB Bladder Cancer AJCC v8|Unresectable Bladder Urothelial Carcinoma|Unresectable Renal Pelvis Urothelial Carcinoma|Unresectable Ureter Urothelial Carcinoma|Unresectable Urethral Urothelial Carcinoma|Unresectable Urothelial Carcinoma
Interventions: OTHER: Diagnostic Laboratory Biomarker Analysis|BIOLOGICAL: Nivolumab|DRUG: Relatlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Envafolimab Combined With Chemotherapy in Neoadjuvant and Conversion Therapy for Head and Neck Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Efficacy and Safety
Interventions: DRUG: Envafolimab combined with chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Trial to Compare the Efficacy, Safety and Pharmacokinetics of HD201 to Herceptin® in HER2+ Early Breast Cancer Patients
Status: COMPLETED
Conditions: HER2 Positive Breast Cancer
Interventions: DRUG: HD201|DRUG: Herceptin|DRUG: Docetaxel|DRUG: Epirubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a 5:2 Diet on Weight Loss and Cardiovascular Risk Factors in Obesity
Status: COMPLETED
Conditions: Obesity|CVD|Dietary Modification
Interventions: OTHER: dietary intervention intermittent energy restriction|OTHER: continuous energy restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Poziotinib and Ramucirumab for the Treatment of EGFR Exon 20 Mutant Stage IV Non-small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Metastatic Lung Non-Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: DRUG: Poziotinib Hydrochloride|BIOLOGICAL: 1429757-68-5, HM781-36B, NOV-1201 Hydrochloride, NOV120101 Hydrochloride, Poziotinib HCl, POZIOTINIB HYDROCHLORIDE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Discoid Lupus Erythematosus of the Scalp and a Trial of Biologic Therapy With Raptiva
Status: WITHDRAWN
Conditions: Discoid Lupus Erthematosus of the Scalp
Interventions: DRUG: Raptiva
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of LJP 394 in Lupus Patients With History of Renal Disease
Status: TERMINATED
Conditions: Lupus Erythematosus, Systemic|Lupus Nephritis
Interventions: DRUG: abetimus sodium (LJP 394) and/or placebo solution|DRUG: abetimus sodium (LJP 394)|DRUG: Phosphate-buffered saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Measure Cerebrospinal Fluid Mutant Huntingtin Protein in Participants With Early Manifest Stage I or Stage II Huntington's Disease
Status: COMPLETED
Conditions: Huntington's Disease
Interventions: OTHER: No Study Drug was Administered in this Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Oxygen Supplementation Study in Obstructive Sleep Apnea (OSA) Patients
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: OTHER: Oxygen therapy|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Manual Therapy in Strenght, Pain and Functional Capacity for Sport Related Groin Pain
Status: RECRUITING
Conditions: Osteitis Pubis|Athletic Pubalgia
Interventions: OTHER: High force lateral distraction|OTHER: Placebo distraction group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interest of Ribavirin in the Maintenance Treatment of Liver Fibrosis Using Low Dose Pegylated Interferon alpha2b in Patients With Chronic Hepatitis C Non Responders to Previous Antiviral Therapy.
Status: COMPLETED
Conditions: Hepatitis C, Chronic|Liver Fibrosis
Interventions: BIOLOGICAL: Peginterferon alfa-2b|DRUG: Ribavirin|DRUG: Ribavirin-Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Mixhers HERTIME Supplements on Menstrual Symptoms
Status: COMPLETED
Conditions: Healthy|Premenstrual Dysphoric Disorder|Premenstrual Syndrome
Interventions: DIETARY_SUPPLEMENT: Mixhers HERTIME|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Different Lenticule Diameters in Myopic Astigmatism Correction With SMILE Procedures
Status: RECRUITING
Conditions: Refractive Errors|Myopic Astigmatism
Interventions: PROCEDURE: Small Incision Lenticule Extraction (SMILE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect and Safety of Fexofenadine Hydrochloride vs Placebo in Patients With Acute Myocardial Infaction: A Randomized Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: ST-segment Elevation Myocardial Infarction (STEMI)
Interventions: DRUG: Fexofenadine Hydrochloride 60mg bid|OTHER: Placebo|DRUG: Fexofenadine Hydrochloride 120mg bid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Hesperidin and Bone Health in Postmenopausal Women
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal
Interventions: DIETARY_SUPPLEMENT: Hesperidin and Calcilock|DIETARY_SUPPLEMENT: Hesperidin|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Daily Disposable Silicone Hydrogel Contact Lens, Stenfilcon A, Clinical Study
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: stenfilcon A|DEVICE: narafilcon A|DEVICE: delefilcon A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of the Vitreous in Response to Intravitreal Injections of Ranibizumab for the Treatment of Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Ranibizumab 0.5 MG/0.05 ML Intraocular Solution [LUCENTIS]
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Patients With Stage III or Stage IV Low-Grade Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Small Lymphocytic Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Small Lymphocytic Lymphoma
Interventions: DRUG: cyclophosphamide|DRUG: fludarabine phosphate|DRUG: vincristine sulfate|DRUG: prednisone|BIOLOGICAL: rituximab|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Indomethacin Eyedrops Compared With Ketorolac Eyedrops for Ocular Inflammation Following Cataract Surgery
Status: COMPLETED
Conditions: Cataract|Inflammation
Interventions: DRUG: Indomethacin ophthalmic solution|DRUG: Ketorolac Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Best Surgical Technique for Optimal Lead Placement in Sacral Neuromodulation - a Comparative Cadaver Study
Status: UNKNOWN
Conditions: Faecal Incontinence
Interventions: PROCEDURE: Sacral neuromodulation in conventional implantation technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Spinal Cord Stimulation Versus Nerve Blocks and Physical Therapy
Status: WITHDRAWN
Conditions: Complex Regional Pain Syndrome|Chronic Pain|Pain
Interventions: DEVICE: Precision SCS|PROCEDURE: Nerve Blocks and PT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Dapagliflozin and Dapagliflozin Plus Saxagliptin in Combination With Metformin in Type 2 Diabetes Patients Compared With Sulphonylurea
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Inadequate Glycaemic Control
Interventions: DRUG: Dapagliflozin|DRUG: Saxagliptin|DRUG: Glimepiride|DRUG: Placebo for dapagliflozin|DRUG: Placebo for saxagliptin|DRUG: Placebo for glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Kangaroo Mother Care Versus Hammock Positioning
Status: COMPLETED
Conditions: Behavior, Child
Interventions: BEHAVIORAL: Kangaroo Mother Care|BEHAVIORAL: Hammock Positioning|BEHAVIORAL: Routine Care of NICU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Helfer Skin Tap Technique on Pain, Fear, and Anxiety in Children Undergoing Intramuscular Injection
Status: COMPLETED
Conditions: Pain, Acute|Fear Anxiety|Child, Only|Injection Site
Interventions: OTHER: Helfer Skin Tap Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: OptiCal Study -Optimizing Fecal Calprotectin Monitoring: a Clinical Study Comparing CalproLab Against PhiCal and Evaluating Its Association With the Gut Microbiome
Status: COMPLETED
Conditions: Crohn Disease|Ulcerative Colitis|Irritable Bowel Syndrome|Celiac Disease|Healthy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness and Acceptability of Insertable Devices for Obstetric Fistula Management
Status: RECRUITING
Conditions: Obstetric Fistula|Fistula|Fistula, Urinary|Fistula, Vaginal
Interventions: DEVICE: Cup|DEVICE: Cup+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CCRT With Twice Weekly Paclitaxel and Cisplatin Followed by Surgery for Locally Advanced Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: Paclitaxel, Cisplatin,Surgery, CCRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of a Triple Eradication Scheme for Helicobacter Pylori Based on Tegoprazan vs Esomeprazole
Status: NOT_YET_RECRUITING
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Tegoprazan|DRUG: Esomeprazole 40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Use of Novel Over-The-Scope-Clip to Prevent Esophageal Stent Migration
Status: NOT_YET_RECRUITING
Conditions: Migration of Implant
Interventions: DEVICE: Over-The-Scope-Clip (OTSC) Stent Fix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study to Investigate Safety and Effects on Heart Rate, Blood Pressure, and Pharmacokinetic Interactions of ACT-334441
Status: TERMINATED
Conditions: Healthy Subjects
Interventions: DRUG: ACT-334441 2 mg|DRUG: ACT-334441 4 mg|DRUG: Placebo|DRUG: Atenolol|DRUG: Diltiazem ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of the Effects of Bio Ceramic and Epoxy Resin-based Sealers on Postoperative Pain After Root Canal Treatment
Status: NOT_YET_RECRUITING
Conditions: Asymptomatic Apical Periodontitis
Interventions: COMBINATION_PRODUCT: Root canal sealer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Crizotinib in Combination With Enzalutamide in Metastatic Castration-resistant Prostate Cancer
Status: COMPLETED
Conditions: Castration-resistant Prostate Cancer
Interventions: DRUG: Crizotinib|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Association Between High Faecal Calprotectin, Increased Intestinal Permeability and Visceral Hypersensitivity in IBS-D Patients
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: PROCEDURE: Colonoscopy with eleven biopsies in the left colon to assess intestinal permeability
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Low Flow Low Gradient Aortic Stenosis Relevance of the (re)Search for a Contractile Reserve
Status: COMPLETED
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: Electrocardiogram|DEVICE: 2D and 3D echocardiography|DEVICE: Dobutamine stress echocardiography|BIOLOGICAL: Blood tests|DEVICE: Cardiac MRI|DEVICE: Cardiac scanner|OTHER: 6-minutes walking test|OTHER: Duke Activity Score
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Efficacy of Pain Control After Total Hip Replacement Between Ultrasound Guided Supra-inguinal Fascia Iliaca Block and Intrathecal Morphine
Status: UNKNOWN
Conditions: Total Hip Replacement|Ultrasound Guided Supra-inguinal Fascia Iliaca Block|Intrathecal Morphine|Postoperative Pain
Interventions: DRUG: Intrathecal morphine|DRUG: Ultrasound guided supra-inguinal fascia iliaca block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Building a Multidisciplinary Research Program to Address Hypertension Disparities: Exploring the Neurocognitive Mechanisms of a Self-Management Intervention for African American Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension
Interventions: BEHAVIORAL: Sharing Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: (Z)-Endoxifen for the Treatment of Premenopausal Women With ER+/HER2- Breast Cancer
Status: RECRUITING
Conditions: Breast Neoplasms|Invasive Breast Cancer|Estrogen-receptor-positive Breast Cancer|HER2-negative Breast Cancer
Interventions: DRUG: (Z)-endoxifen|DRUG: exemestane|DRUG: goserelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accelerated High-dose Sequential Bilateral Theta Burst Stimulation for Treatment Resistant Depression
Status: NOT_YET_RECRUITING
Conditions: Treatment Resistant Depression
Interventions: DEVICE: Sequential bilateral theta burst stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT