pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparing a Group-based Guided Self-help Approach to Pure Self-help for the Treatment of BED
Status: COMPLETED
Conditions: Binge Eating Disorder
Interventions: BEHAVIORAL: Binge Focused Therapy (BFT)|BEHAVIORAL: CBT Unguided Self Help (CBT USH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sarpogrelate Drug Interaction
Status: COMPLETED
Conditions: Hypertension|Peripheral Artery Disease
Interventions: DRUG: Sarpogrelate pretreatment|DRUG: Sarpogrelate|DRUG: Metoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study Comparing the New Immunosuppressive Drug Gusperimus With the Conventional Treatment in Wegener's Granulomatosis
Status: TERMINATED
Conditions: Wegeners Granulomatosis
Interventions: DRUG: Gusperimus + glucocorticoids|DRUG: cyclophosphamide followed by methotrexate (azathioprine) + glucocorticoids or methotrexate (azathioprine) + glucocorticoids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient-reported Outcome Measures (PROMs) in Patients With Bodily Stress Syndrome: Protocol for a Prospective Cohort Study
Status: UNKNOWN
Conditions: Fibromyalgia|Irritable Bowel Syndrome|Somatic Symptom|Chronic Fatigue Syndrome|Fatigue|Dysphagia|Exhaustion; Syndrome
Interventions: BEHAVIORAL: Psychosocial interventions
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Propofol-Based Total Intravenous Anesthesia Versus Anesthesia With Sevoflurane on Long-term Outcomes With Patients Undergoing Elective Excision of Primary Liver Tumors
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Laparoscopic Versus Open Operations for Colon Cancer
Status: UNKNOWN
Conditions: Colonic Neoplasms
Interventions: PROCEDURE: Laparoscopic-assisted colectomy|PROCEDURE: Conventional open colectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endobronchial Ultrasound Versus Mediastinoscopy in Patients With Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Lung Cancer
Interventions: PROCEDURE: Endobronchial Ultrasound|PROCEDURE: Mediastinoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neoadjuvant Immunotherapy Plus Chemotherapy in Borrmann Type 4 and Large Type 3 Gastric Cancer
Status: RECRUITING
Conditions: Stomach Neoplasms|Gastric Cancer|Linitis Plastica of Stomach
Interventions: DRUG: Tislelizumab|DRUG: Oxaliplatin|DRUG: S-1|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Are Stabilization Exercises Effective After Epidural Steroid Injection in Patients With Cervical Radiculopathy?
Status: COMPLETED
Conditions: Pain, Neck|Cervical Radiculopathy|Pain, Radiating
Interventions: PROCEDURE: Cervical Interlaminar Epidural Steroid Injection|OTHER: Neck Stabilization Exercises|OTHER: Neck and Scapular Stabilization Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Atezolizumab Plus Nab-Paclitaxel in the Treatment of Unresectable Locally Advanced or Metastatic PD-L1-Positive Triple-Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple-Negative Breast Cancer
Interventions: DRUG: Atezolizumab|DRUG: Nab-Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 24 Week Efficacy Study of Inhaled Umeclidinium (UMEC) in Patients of Chronic Obstructive Pulmonary Disease (COPD) Using a Novel Dry Powder Inhaler (NDPI)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Umeclidinium bromide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Insulin Profile of Biphasic Insulin Aspart 70 to That of Biphasic Insulin Aspart 30 in Healthy Volunteers
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart 70|DRUG: biphasic insulin aspart 30
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quick Start Insertion of Mirena and ParaGard
Status: COMPLETED
Conditions: Bleeding|Cramping|Pregnancy With IUD in Place|IUD Expulsion|IUD Removal
Interventions: OTHER: Text message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of BDNF Pathway Biomarkers in the Cerebrospinal Fluid in Patients With Huntington's Disease
Status: RECRUITING
Conditions: Huntington Disease
Interventions: PROCEDURE: Brain MRI|PROCEDURE: Lumbar Punction|GENETIC: Blood sample|OTHER: Cognitive evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: CEM-Plate and CEM-Cage First-In-Human Use Efficacy Study
Status: RECRUITING
Conditions: Neck Pain|Spondylosis|Spondylosis With Myelopathy|Spondylosis With Radiculopathy|Spondylosis With Radiculopathy Cervical Region|Intervertebral Disc Disorder Cervical
Interventions: DEVICE: CEM-Plate Anterior Cervical Plating System and CEM-Cage Cervical Interbody System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In Vitro Myometrial Contractions in Laboring and Non-laboring Women
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Oxytocin|DRUG: Ergonovine|DRUG: Prostaglandin F2alpha|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy Study of RiaGev in Healthy Adults
Status: UNKNOWN
Conditions: Metabolic Syndrome|Premature Aging
Interventions: DIETARY_SUPPLEMENT: RiaGev
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison of Free-breathing 3D Quantitative Perfusion in Patients With MINOCA and MINOCA-mimics
Status: RECRUITING
Conditions: Myocardial Infarction With Non-Obstructive Coronary Artery|Myocarditis Acute|Takotsubo Cardiomyopathy|Spontaneous Coronary Artery Dissection|Non ST Elevation Myocardial Infarction
Interventions: DIAGNOSTIC_TEST: CMR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Dose-finding Study With Lu AA24530 in Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Lu AA24530|DRUG: Duloxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing the Effects of Adolescent Alcohol Treatment With Acetyl-L-Carnitine
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use Disorder
Interventions: DRUG: Acetyl-l-carnitine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prosthetic Maintenance of Two Implant-Retained Overdentures Reinforced With PEKK Versus Co-Cr Frameworks
Status: COMPLETED
Conditions: Completely Edentulous
Interventions: DEVICE: Two implant -retained overdenture reinforced with Co-Cr framework|DEVICE: Two implant -retained overdenture reinforced with PEEK framework
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Duration of Face Down Positioning for Full-Thickness Macular Hole Repair
Status: RECRUITING
Conditions: Macular Holes
Interventions: BEHAVIORAL: 3 Days of face-down positioning|BEHAVIORAL: 7 Days of face-down positioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Ketamine in Malignant Neuropathic Pain Relief
Status: WITHDRAWN
Conditions: Pain, Intractable
Interventions: DRUG: Ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Finerenone in Patients With Primary Membranous Nephropathy
Status: NOT_YET_RECRUITING
Conditions: Primary Membranous Nephropathy
Interventions: DRUG: ACEI/ARB+ finerenone|DRUG: ACEI/ARB+ Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Double-Blind, Randomized, Active- and Placebo-Controlled, Multiple-Dose Multi-Center Phase 3 Study of the Safety and Efficacy of CL-108 in the Treatment of Moderate to Severe Acute Pain and Opioid-Induced Nausea and Vomiting (OINV)
Status: COMPLETED
Conditions: Pain|Nausea|Vomiting
Interventions: DRUG: CL-108 (hydrocodone 7.5 mg, acetaminophen 325 mg, promethazine 12.5 mg)|DRUG: Placebo|DRUG: Norco (hyrdocodone 7,5 mg, acetaminophen 325 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-Center, Double-Masked Evaluation of the Efficacy and Safety of CSF-1 in the Treatment of Presbyopia
Status: COMPLETED
Conditions: Presbyopia
Interventions: DRUG: CSF-1|DRUG: CSF-1 Component #1|DRUG: CSF-1 Component #2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Study Will Evaluate the Effect of AZD9164 in Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: AZD9164|DRUG: Tiotropium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Different Ketone Supplements on β-OHB and Blood Glucose in Healthy Individuals
Status: COMPLETED
Conditions: Ketosis|Blood Glucose
Interventions: DIETARY_SUPPLEMENT: (R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester|DIETARY_SUPPLEMENT: Beta-hydroxybutyric acid|DIETARY_SUPPLEMENT: 1,3-Butanediol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Efficacy and Safety of Toripalimab or Placebo Combined With Chemotherapy in Treatment-naive Advanced NSCLC
Status: COMPLETED
Conditions: Treatment-naive Advanced Non-small Cell Lung Cancer
Interventions: DRUG: TORIPALIMAB INJECTION (JS001 ) combine with chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: White Noise to Improve Sleep in the Medical Intensive Care Unit (MICU): a Pilot and Feasibility Study
Status: COMPLETED
Conditions: Sleep Deprivation
Interventions: DEVICE: white noise|BEHAVIORAL: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Obexelimab in Patients With Relapsing Multiple Sclerosis (MoonStone)
Status: RECRUITING
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: Obexelimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Nitric Oxide Generator, Nebivolol as a Disease Modifier in Patients With Diabetic Neuropathy.
Status: NOT_YET_RECRUITING
Conditions: Diabetic Neuropathy Peripheral
Interventions: DRUG: Nebivolol+ Standard care arm|DRUG: Epalrestat + Alpha Lipoic Acid +Standard care|DRUG: Standard care alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Alveolar Bone Defects Using Aastrom Biosciences Autologous Tissue Repair Cell Therapy
Status: COMPLETED
Conditions: Alveolar Bone Loss
Interventions: BIOLOGICAL: Tissue Repair Cells (TRC)|DEVICE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Subacromial Ultrasound Guided and Systemic Steroid Injection for Frozen Shoulder
Status: TERMINATED
Conditions: Frozen Shoulder|Shoulder Pain|Bursitis
Interventions: DRUG: Compound betamethasone Injection(Gluteal muscle injection)|DRUG: Compound betamethasone Injection(Subacromial Ultrasound Guided injection)|BEHAVIORAL: Physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Comparability of Ipratropium Bromide Hydrofluoroalkane (HFA)-134a Inhalation Aerosol to the Market Standard, Atrovent® Chlorofluorocarbon (CFC) Inhalation Aerosol, in Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Ipratropium bromide HFA-134a inhalation aerosol|DRUG: Atrovent® CFC inhalation aerosol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Hysterectomy With Vaginal Vault Suspension to the Uterosacral Ligaments for Stage II-III Pelvic Organ Prolapse.
Status: UNKNOWN
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: Vaginal vault suspension to the uterosacral ligaments|PROCEDURE: McCall culdoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Transoral Incisionless Fundoplication (TIF) Versus Sham for Treatment of Gastroesophageal Reflux Disease (GERD)
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease|Hiatal Hernia
Interventions: PROCEDURE: Transoral Incisionless Fundoplication (TIF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of 122-0551 Foam Versus Vehicle Foam in Subjects With Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: 122-0551 Foam|DRUG: Vehicle Foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Traditional Versus Alternative Alignment in TKR
Status: RECRUITING
Conditions: Osteo Arthritis Knee
Interventions: OTHER: TKR with mechanical alignment method|OTHER: TKR with alternative alignment method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilocarpine, Brimonidine, Oxymetazoline (PBO) Compound to Control Presbyopia Symptoms
Status: UNKNOWN
Conditions: Presbyopia
Interventions: DRUG: Pilocarpine, brimonidine, oxymetazoline, hyaluronic acid, bromfenac (PBOHB) compound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early LA Venting During Venoaterial ECMO Support
Status: COMPLETED
Conditions: Cardiogenic Shock|Extracorporeal Membrane Oxygenation Support|Refractory Pulmonary Edema
Interventions: PROCEDURE: Left atrial venting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Intervention for Refractory Granulomatous Lobular Mastitis
Status: RECRUITING
Conditions: Refractory Granulomatous Lobular Mastitis
Interventions: PROCEDURE: Focus clearing + whole breast exploration and washing + one-stage micro plastic surgery No Intervention: Extensive lesion excision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Proof-of-concept Study to Reduce Treatment Burden in Haemophilia Participants Receiving Factor VIII and Factor IX Infusions
Status: COMPLETED
Conditions: Hemophilia
Interventions: DEVICE: Virtual-reality (VR) Based Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prehabilitation Plus ERAS vs ERAS in Gynecological Surgery
Status: WITHDRAWN
Conditions: Gynecologic Surgical Procedures|Enhanced Recovery After Surgery
Interventions: OTHER: Prehabilitation Program + Enhanced Recovery After Surgery|OTHER: Enhanced Recovery After Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Colchicine in Percutaneous Coronary Intervention
Status: COMPLETED
Conditions: Coronary Artery Disease|Acute Coronary Syndrome
Interventions: DRUG: Colchicine vs Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Proprioceptive Reweighting Ability on Lower-limb Biomechanics During Functional Tasks
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injuries
Interventions: OTHER: Star Excursion Balance Test|OTHER: Single leg Drop Vertical Jump|OTHER: Unplanned sidestep cutting manoeuvre|OTHER: Tendon vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Personalized Physical Back Training Program to Improve Physical Functioning in People With Non-specific Low Back Pain: A Feasibility Study
Status: NOT_YET_RECRUITING
Conditions: Exercise Therapy|Exercise|Low Back Pain
Interventions: OTHER: Personalized physical back training program|OTHER: Non-personalized physical back training program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Resveratrol on Metabolic Parameters and Oocyte Quality in PCOS Patients
Status: COMPLETED
Conditions: Androgen Profile|Inflammatory Markers|IVF Outcome
Interventions: DIETARY_SUPPLEMENT: Resveratrol|DIETARY_SUPPLEMENT: Placebo pills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of the Efficacy of Interdental Floss to Water Flosser Around Dental Implants
Status: COMPLETED
Conditions: Implant Site Bleeding
Interventions: DEVICE: comparing interdental floss to water flosser around dental implants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Leg(s) in Cerebral Palsy
Status: COMPLETED
Conditions: Lower Limb Spasticity Due to Cerebral Palsy
Interventions: DRUG: IncobotulinumtoxinA (16 Units per kg body weight)|DRUG: IncobotulinumtoxinA (12 Units per kg body weight)|DRUG: IncobotulinumtoxinA (4 Units per kg body weight)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DISsection RE-entry Evaluation With Absorb Bioresorbable Vascular Scaffolds in CTO.
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: CTO PCI using Absorb Bioresorbable Vascular Scaffolds
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Term Response of Breast Milk Micronutrient Concentrations to a Lipid Based Nutrient Supplement in Guatemalan Women
Status: COMPLETED
Conditions: Malnutrition
Interventions: OTHER: Treatment 1: Control|DIETARY_SUPPLEMENT: Treatment 2: Bolus (LNS)|DIETARY_SUPPLEMENT: Treatment 3: Divided Dose (LNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Renvela in Patients With Chronic Kidney Disease Not On Dialysis And Hyperphosphatemia In China
Status: COMPLETED
Conditions: Hyperphosphatemia
Interventions: DRUG: Placebo|DRUG: Sevelamer Carbonate (GZ419831)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Over-the-scope-clip for Prevention of Rebleeding in High Risk Peptic Ulcers
Status: COMPLETED
Conditions: Ulcer Bleeding|Upper Gastrointestinal Tract Bleeding
Interventions: DEVICE: Over-the-scope clip (OTSC)|DEVICE: Conventional Endoscopic Haemostasis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Incorporation of Safe Sleep Education Into m-Health Technology
Status: NOT_YET_RECRUITING
Conditions: Sudden Infant Death
Interventions: BEHAVIORAL: Safety in Seconds mobile app: Safe Sleep Education|BEHAVIORAL: Safety in Seconds mobile app: Car Seat Safety Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nitric Oxide Releasing Solution (NORS) Footbath to Treat Athlete's Foot
Status: COMPLETED
Conditions: Tinea Pedis
Interventions: DRUG: Nitric Oxide|DRUG: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: to Evaluate the Safety, Tolerability and Pharmacokinetics of Four Formulations of LY03009 in Healthy Volunteers
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: DRUG: LY03009 F1|DRUG: LY03009 F2|DRUG: LY03009 F3|DRUG: LY03009 F4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Two-part Single and Multiple Dose Study to Assess the Safety , Pharmacokinetics and Effects of AZD3293 in Healthy Japanese Young and Elderly Volunteers
Status: COMPLETED
Conditions: Healthy Japanese Young and Elderly Male and Non-fertile Female Volunteers
Interventions: DRUG: AZD3293|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Financial Incentives to Reduce Pediatric Tobacco Smoke Exposures
Status: COMPLETED
Conditions: Asthma|Incentives|Tobacco Smoking
Interventions: BEHAVIORAL: Incentive plan|BEHAVIORAL: Smoking cessation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Weekly Topotecan With Docetaxel in Recurrent Small Cell Lung Cancer
Status: TERMINATED
Conditions: Mediastinal Neoplasms
Interventions: DRUG: Intravenous Topotecan|DRUG: Intravenous Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Duloxetine Compared to Escitalopram and Placebo in the Treatment of Patients With Depression
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: duloxetine|DRUG: escitalopram|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease|Mild Cognitive Impairment|Logopenic Progressive Aphasia|Amnestic Symptoms
Interventions: DEVICE: Active rTMS|DEVICE: Sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Compare Different Drugs Used to Prevent Serious Bacterial Infections in HIV-Positive Children
Status: COMPLETED
Conditions: Bacterial Infections|Pneumonia, Pneumocystis Carinii|HIV Infections
Interventions: DRUG: Azithromycin|DRUG: Atovaquone|DRUG: Sulfamethoxazole-Trimethoprim
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Effects of Statin Therapy on Vascular Properties and Outcomes in Diastolic Heart Failure Patients
Status: TERMINATED
Conditions: Diastolic Heart Failure
Interventions: DRUG: Atorvastatin|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Continues Cicatricial Perfusion of Ropivacaine Versus Placebo After Mastectomy : Rehabilitation After Treatment
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Ropivacaine|DRUG: physiological saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety and Pharmacological Effect of a Single Intravenous Infusion of Belantamab in Male and Female Participants Aged 18 to 75 With Moderate to Severe Systemic Lupus Erythematosus
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: Belantamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Isokinetic Performance After Cruciate-substituting Ultra-congruent and Posterior Stabilized Total Knee Arthroplasties
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Knee Arthritis
Interventions: DEVICE: Vanguard® Knee System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Iron Therapy and Exercise Training in Patients With Heart Failure and Iron Deficiency
Status: WITHDRAWN
Conditions: Heart Failure With Reduced Ejection Fraction|Exercise Training|Ferric Carboxymaltose
Interventions: BEHAVIORAL: Initial exercise training|DRUG: Initial FCM|DRUG: Subsequent FCM|BEHAVIORAL: Subsequent exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Feasibility And Safety Study of Fluorescein-Specific (FITC-E2) CAR T Cells In Combination With Parenterally Administered Folate-Fluorescein (UB-TT170) For Osteogenic Sarcoma
Status: RECRUITING
Conditions: Osteosarcoma
Interventions: BIOLOGICAL: SCRI-E2CAR_EGFRtv1|DRUG: UB_TT170
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Harvest for Health in Older Cancer Survivors
Status: COMPLETED
Conditions: Cancer Survivor
Interventions: BEHAVIORAL: Immediate Gardening Intervention|OTHER: Delayed Gardening Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Open Multi-centre Investigation to Evaluate Signs and Symptoms of Local Inflammation/Infection on Chronic Ulcers and Partial Thickness Burns When Using Mepilex Border Ag as an Anti-microbial Wound Dressing
Status: COMPLETED
Conditions: Inflammation|Burns|Ulcers
Interventions: DEVICE: Mepilex Border Ag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carnitine Supplementation and Bone Mineral Density
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DIETARY_SUPPLEMENT: L-carnitine|DIETARY_SUPPLEMENT: L-leucine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Vitamin D, Glucose Control and Insulin Sensitivity in African-Americans
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: cholecalciferol|OTHER: microcrystalline cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Mild Hypoglycaemia on Cognitive Function in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type II|Hypoglycemia|Cognitive Change
Interventions: OTHER: Hypoglycaemic clamp|OTHER: Euglycaemic clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Extension Study to Assess Long Term Safety, Tolerability, and Efficacy of Valsartan and Enalapril Combined and Alone in Children With Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Valsartan|DRUG: Enalapril|DRUG: placebo matched to enalapril|DRUG: placebo matched to valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of AVACEN 100 on Brachial Artery Blood Flow and Heart Rate Variability
Status: UNKNOWN
Conditions: Blood Flow|Heart Rate Variability
Interventions: DEVICE: Heat|DEVICE: Vacuum|DEVICE: sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Miltefosine and GM-CSF in Cutaneous Leishmaniasis
Status: COMPLETED
Conditions: Cutaneous Leishmaniasis
Interventions: DRUG: Sbv|DRUG: Miltefosine plus placebo|DRUG: Miltefosine plus GM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intralumenal Effects on Cholesterol Absorption/Synthesis
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Bile Acids (Cholic, Ursodeoxycholic, Chenodeoxycholic)|DIETARY_SUPPLEMENT: Sphingomyelin|OTHER: C13 Stable isotope of Cholesterol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Importance of Adrenomedullin (AM) on ACTH-Cortisol-Glucose Axis
Status: COMPLETED
Conditions: Systemic Inflammatory Response Syndrome|Hyperglycemia
Interventions: PROCEDURE: Blood AM, IL-6, ACTH, Cortisol, Glucose and Insulin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rerouting Seton Versus LIFT for Complex Anal Fistula
Status: UNKNOWN
Conditions: Anal Fistula
Interventions: PROCEDURE: Rerouting seton|PROCEDURE: LIFT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carboplatin, Etoposide, and Atezolizumab With or Without Trilaciclib (G1T28), a CDK4/6 Inhibitor, in Extensive-Stage SCLC
Status: TERMINATED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Trilaciclib|DRUG: Placebo|DRUG: Carboplatin|DRUG: Etoposide|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: capecitabine|DRUG: fluorouracil|DRUG: irinotecan hydrochloride|OTHER: diagnostic laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety,Tolerability,and Pharmacokinetics Profiles of GB001 Recombinant Peptide Spray in Healthy Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DRUG: GB001 recombinant peptide spray|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rituximab, Fludarabine, Mitoxantrone, Dexamethasone (R-FND) Plus Zevalin for High-Risk Follicular Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Fludarabine|DRUG: Mitoxantrone|DRUG: Rituximab|DRUG: Zevalin|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraosseous Access During Pediatric Resuscitation
Status: UNKNOWN
Conditions: Cardiac Arrest
Interventions: DEVICE: Peripheral venous catheterization|DEVICE: Jamshidi|DEVICE: BIG|DEVICE: Cook|DEVICE: EZIO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRC-063 in Adolescent ADHD
Status: COMPLETED
Conditions: ADHD
Interventions: DRUG: Placebo|DRUG: PRC-063 25 mg|DRUG: PRC-063 45 mg|DRUG: PRC-063 70 mg|DRUG: PRC-063 85 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Efficacy and Safety of Roxadustat (FG-4592) for Treatment of Anemia in Pediatric Patients With CKD
Status: UNKNOWN
Conditions: Anemia Associated With Chronic Kidney Disease
Interventions: DRUG: Roxadustat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Safety and Tolerability of the Fixed- Dose Combination of Obeticholic Acid and Bezafibrate
Status: NOT_YET_RECRUITING
Conditions: Primary Biliary Cholangitis
Interventions: DRUG: FDC tablet (OCA 5 mg + BZF 400 mg SR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of APRIL-BAFF-Bicephali CAR-T in Relapsed, Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: OTHER: APRIL-BAFF-Bicephali CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study Between VHX-896 Tablets and Iloperidone Tablets in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: VHX-896 and iloperidone|DRUG: Iloperidone and VHX-896
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromodulation of Social Cognitive Circuitry in People With Schizophrenia Spectrum Disorders
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorders
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation|DEVICE: Repetitive Transcranial Magnetic Stimulation (Intermittent Theta Burst Stimulation)|DEVICE: Repetitive Transcranial Magnetic Stimulation (Sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Orthopedic Mandibular Advancement in Class II Division 1 Malocclusion on Pharyngeal Airway
Status: COMPLETED
Conditions: ClassII Division 1 Malocclusion|Mandibular Retrognathism
Interventions: DEVICE: Twin Block|DEVICE: Fixed orthodontic appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Regional Arterial Infusion of Low Molecular Weight Heparin in Patients With Severe Acute Pancreatitis
Status: UNKNOWN
Conditions: Acute Pancreatitis
Interventions: PROCEDURE: Continuous regional arterial infusion of low molecular weight heparin in celiac trunk|OTHER: General treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Muscle Energy Technique With Or Without First Rib Mobilization In Adhesive Capsulitis
Status: COMPLETED
Conditions: Adhesive Capsulitis
Interventions: OTHER: first rib mobilization|OTHER: muscle energy technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Usefulness of Selegiline as an Aid to Quit Smoking - 1
Status: COMPLETED
Conditions: Tobacco Use Cessation
Interventions: DRUG: Selegiline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hipoenergetic Effect of Diet Associated or Not With the Consumption of Coconut Flour in Women With Overweight
Status: COMPLETED
Conditions: Obesity|Cardiovascular Risk Factor
Interventions: DIETARY_SUPPLEMENT: Coconut flour|BEHAVIORAL: Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Open-label Study to Assess Response to COVID-19 Vaccine in Multiple Sclerosis Participants Treated With Ofatumumab
Status: TERMINATED
Conditions: Relapsing Multiple Sclerosis (RMS)
Interventions: DRUG: Ofatumumab|BIOLOGICAL: mRNA COVID-19 vaccine|DRUG: interferon or glatiramer acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gluten Free Diet in Diminishing Side Effects Patients With Acute Myeloid Leukemia Undergoing Induction Chemotherapy
Status: TERMINATED
Conditions: Acute Myeloid Leukemia
Interventions: OTHER: Best Practice|PROCEDURE: Biospecimen Collection|OTHER: Dietary Intervention|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: hUC Mesenchymal Stem Cells (19#iSCLife®-UT) Therapy for Patients With Thin Endometrial Infertility
Status: RECRUITING
Conditions: Infertility, Female
Interventions: BIOLOGICAL: human umbilical cord mesenchymal stem cell complex collagen|PROCEDURE: intrauterine injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Different Anesthesia Machine Modalities on Bariatric Surgery Patients: a Prospective Randomized Controlled Study
Status: RECRUITING
Conditions: Ventilation|Bariatric Surgery|Intracranial Pressure|Carbon Dioxide
Interventions: DEVICE: PC Ventilation mode|DEVICE: VC Ventilation mode|DEVICE: PRVC Ventilation mode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of JNJ-63709178, a Humanized CD123 x CD3 DuoBody in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: JNJ-63709178
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cost-effectiveness Evaluation of the Use of a Patient Specific Instrument for Surgical Resection of Malignant Bone Tumor Within the Pelvis Versus the Conventional Surgical Treatment
Status: COMPLETED
Conditions: Sarcoma, Bone Tumor
Interventions: DEVICE: Patient specific instrument|PROCEDURE: Conventional surgical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azacitidine After Chemotherapy and Donor Lymphocyte Infusion in Patients With Relapsed Acute Myeloid Leukemia or Myelodysplastic Syndrome Previously Treated With Donor Stem Cell Transplant
Status: COMPLETED
Conditions: Leukemia, Myeloid, Acute|Myelodysplastic Syndromes
Interventions: DRUG: Azacitidine|DRUG: Pre-DLI Salvage Chemotherapy|BIOLOGICAL: Donor Leukocyte Infusion (DLI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Adjuvant SOX Plus PL-1 Antibody and FLOT Plus PD-1 Antibody for Locally Advanced dMMR Gastric Cancer
Status: RECRUITING
Conditions: Gastric Cancer|Immune-related Adverse Event|Chemotherapeutic Toxicity
Interventions: DRUG: SOX+PD-1 antibody|DRUG: FLOT+PD-1 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Hymovis ONE® (32mg/4ml) Intrarticular Injection in Active Patients With Knee Overuse Syndrome
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Hymovis® ONE (32 mg/4 ml)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of Safe and Effective Dose of Romiplostim (AMG 531) in Subjects With Myelodysplastic Syndrome (MDS)Receiving Hypomethylating Agents
Status: COMPLETED
Conditions: MDS|Myelodysplastic Syndromes|Thrombocytopenia
Interventions: DRUG: Placebo|BIOLOGICAL: AMG 531 (Romiplostim)|DRUG: Azacitidine|DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of [14C]-LY3537982 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3537982|DRUG: [¹⁴C]-LY3537982|DRUG: [¹⁴C]-LY3537982
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Electroacupuncture on Menstrual Frequency in Women With Polycystic Ovary Syndrome: Study Protocol
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome
Interventions: OTHER: Acupuncture|OTHER: Sham-acupuncture group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Postoperative Analgesic Efficacy of Suprainguinal Fascia Iliaca Block
Status: COMPLETED
Conditions: Regional Anesthesia
Interventions: DEVICE: Low frequency convex probe (ESAOTE Fixed Color Doppler Ultrasonography Device, Italy)|DEVICE: Patient controlled analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Food Reward Circuit Change by Orthodontics
Status: UNKNOWN
Conditions: Eating Disorders|Eating Behavior|Eating Habit|Orthodontic Appliance Complication
Interventions: DIAGNOSTIC_TEST: T 0 Diffusion Tensor MR|DIAGNOSTIC_TEST: T 1 Diffusion Tensor MR|DIAGNOSTIC_TEST: T 2 Diffusion Tensor MR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Comparison of Thoracic Electrical Bioimpedance and FloTrac/Vigileo
Status: NOT_YET_RECRUITING
Conditions: Stroke Volume Variation|SVV-FloTrac|Thoracic Electrical Bioimpedance|Fluid Responsiveness
Interventions: DEVICE: Flotrac Group|DEVICE: BioZ Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: WHIte MAtter Hyperintensity Shape and Glymphatics
Status: RECRUITING
Conditions: Cerebral Small Vessel Diseases|Dementia, Mixed|Dementia, Vascular|Mild Cognitive Impairment|Cognitive Impairment|Cognitive Decline
Interventions: OTHER: 3T MRI scan|OTHER: 7T MRI scan|BEHAVIORAL: Neuropsychological assessment|OTHER: General baseline data
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adapting Mindful Eating Program for French Overweight/Obese Population
Status: RECRUITING
Conditions: Overweight and Obesity
Interventions: BEHAVIORAL: Mindful Eating Intervention (AC group)|BEHAVIORAL: Conventional Dietetic Intervention (DC group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of ChAdOx1 and MVA Vaccines Against MAGE-A3 and NY-ESO-1
Status: SUSPENDED
Conditions: Non-small Cell Lung Cancer (NSCLC)|Esophageal Neoplasms
Interventions: BIOLOGICAL: ChAdOx1-MAGEA3-NYESO|BIOLOGICAL: MVA-MAGEA3|COMBINATION_PRODUCT: Standard of care treatment|BIOLOGICAL: MVA-NYESO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Application of Ozone Gas for Infected Ulcers
Status: COMPLETED
Conditions: Ulcer|Wound Infection
Interventions: OTHER: Ozone|DEVICE: Placebo|OTHER: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT