pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Anti-viral Action Against Type 1 Diabetes Autoimmunity
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Comirnaty Injectable Product|DRUG: Sodium Chloride 0.9% Inj
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Systolic Dysfunction
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension, Pulmonary|Ventricular Dysfunction, Left
Interventions: DRUG: Riociguat (Adempas, BAY63-2521)|DRUG: Riociguat (Adempas, BAY63-2521)|DRUG: Riociguat (Adempas, BAY63-2521)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Aflibercept for Retinal Non-Perfusion in Proliferative Diabetic Retinopathy
Status: COMPLETED
Conditions: Proliferative Diabetic Retinopathy
Interventions: DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thin Wire Versus Thick Wire Snare for Cold Snare Polypectomy of Diminutive Polyps
Status: COMPLETED
Conditions: Polyps
Interventions: DEVICE: Thin Wire Snare|DEVICE: Thick Wire Snare
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Cognitive Behavioral Therapy vs. Prescriptive Diet in Short and Medium-term Control of Body Weight
Status: UNKNOWN
Conditions: Obesity
Interventions: BEHAVIORAL: Cognitive Behavioral (B)|OTHER: Prescriptive Diet (A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Simufilam (PTI-125), 100 mg, for Mild-to-moderate Alzheimer's Disease Patients
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Simufilam 100 mg oral tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cortisol and the Formation of Intrusive Memories
Status: COMPLETED
Conditions: Intrusive Memories
Interventions: BEHAVIORAL: Stress Film|DRUG: Hydrocortisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pragmatic Investigation of Volume Targeted Ventilation-1
Status: COMPLETED
Conditions: Respiratory Failure|Acute Respiratory Distress Syndrome (ARDS)|Ventilator Lung
Interventions: PROCEDURE: mode of mechanical ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial for Prevention of Recurrent Ischemic Priapism in Men With Sickle Cell Disease: A Pilot Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Priapism Due to Sickle Cell Disease
Interventions: DRUG: Tadalafil|DRUG: Hydroxyurea|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: PNEUmonia DOSing in Critically Ill Patients (PNEUDOS)
Status: UNKNOWN
Conditions: Pneumonia
Interventions: OTHER: Blood sampling|OTHER: Epithelial lining fluid sampling|OTHER: Urine sampling|DRUG: Study antibiotics include benzylpenicillin, ceftriaxone, meropenem, and piperacillin/tazobactam
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Melphalan and Dexamethasone With or Without Bortezomib in Treating Patients With Previously Untreated Systemic Light-Chain Amyloidosis
Status: COMPLETED
Conditions: Light Chain Deposition Disease|Primary Systemic Amyloidosis
Interventions: DRUG: melphalan|DRUG: dexamethasone|DRUG: bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Educational Intervention to Improve HPV Vaccination Decision Quality
Status: COMPLETED
Conditions: HPV Vaccination Decision Quality
Interventions: BEHAVIORAL: Tailored educational materials|BEHAVIORAL: Untailored educational materials|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Immunogenicity of Quadrivalent Influenza mRNA Vaccine MRT5413 in Adult Participants18 Years of Age and Older
Status: COMPLETED
Conditions: Influenza Immunization
Interventions: BIOLOGICAL: Quadrivalent Influenza mRNA Vaccine MRT5413|BIOLOGICAL: Quadrivalent Recombinant Influenza Vaccine|BIOLOGICAL: Quadrivalent Influenza Standard Dose Vaccine|BIOLOGICAL: Quadrivalent Influenza High-Dose Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Response To Medical Therapy in Inflammatory Bowel Disease Patients Carrying-out a Prescribed Exercise Programme
Status: UNKNOWN
Conditions: Inflammatory Bowel Diseases
Interventions: BEHAVIORAL: Physician-prescribed Exercise Programme|DRUG: Best Medical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-arterial Thrombolysis After Successful Thrombectomy for Acute Ischemic Stroke in the Posterior Circulation (IAT-TOP)
Status: RECRUITING
Conditions: Acute Ischemic Stroke|Arterial Thrombosis|Posterior Circulation Brain Infarction
Interventions: DRUG: intra-arterial alteplase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Anterior Cruciate Ligament Rupture; RecOnsTruction Or Repair?
Status: ACTIVE_NOT_RECRUITING
Conditions: Anterior Cruciate Ligament Injury
Interventions: PROCEDURE: ACL Repair|PROCEDURE: ACL reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison Of Outcome Of Microneedling With Autologous PRP Vs Microneedling With Topical Insulin In Treatment Of Post Acne Atrophic Scars.
Status: COMPLETED
Conditions: ATROPHIC ACNE SCARS
Interventions: DRUG: PRP( platelet rich plasma) and Insulin human
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antibiotic Prophylaxis in Primary Joint Arthroplasty of the Hip and Knee.
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Hip|Arthroplasty, Replacement, Knee|Antibiotic Prophylaxis
Interventions: DRUG: Single shot antibiotic prophylaxis|DRUG: Multiple shot antibiotic prophylaxis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate Safety and Pharmacokinetics of ZB002 in Healthy Participants and Participants With Rheumatoid Arthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Volunteers|Rheumatoid Arthritis
Interventions: DRUG: ZB002|DRUG: Placebo|DRUG: ZB002|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Dasatinib vs Imatinib in Patients With Chronic Myeloid Leukemia (CML) Who Did Not Have Favorable Response to Imatinib
Status: COMPLETED
Conditions: Chronic Phase Chronic Myeloid Leukemia
Interventions: DRUG: Imatinib|DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Romiplostim for Chemotherapy-induced Thrombocytopenia in Adult Subjects With Non-small Cell Lung Cancer (NSCLC), Ovarian Cancer, or Breast Cancer
Status: RECRUITING
Conditions: Chemotherapy-induced Thrombocytopenia
Interventions: DRUG: Romiplostim|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eliminating Breast Surgery for Breast Cancer Patients With Clinical Complete Response to Neoadjuvant Systemic Therapy
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: RADIATION: Neoadjuvant Chemotherapy combined with Neoadjuvant Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SA Versus SOI Surfaces for Single Implant-supported Crown
Status: UNKNOWN
Conditions: Dental Implant Failed|Bone Resorption
Interventions: PROCEDURE: Placement of dental implants (surgical procedure)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bracing for Patellofemoral Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis|Metabolic Disease
Interventions: DEVICE: Womac|DEVICE: Lequesne|DEVICE: Timed-up-and-go (TUG)|DEVICE: five-times-sit-to-stand-test (FTSST)|DEVICE: Six-minute walk test.|DEVICE: functional patellofemoral neoprene brace|DEVICE: neoprene sleeve brace.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Lamivudine Therapy for Chronic Hepatitis B
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: PROCEDURE: Blood Testing|PROCEDURE: Percutaneous Liver Biopsy|PROCEDURE: Lamivudine Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of Degenerescence CSF Hallmarks in Older Bipolar Patients
Status: UNKNOWN
Conditions: Bipolar Disorder|Alzheimer's Disease
Interventions: PROCEDURE: lumbar puncture (LP)|PROCEDURE: brain MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Efficacy of Doravirine + Dolutegravir Dual Therapy in the Context of Antiretroviral Therapy Switch
Status: RECRUITING
Conditions: HIV-1-infection
Interventions: DRUG: Doravirine|DRUG: Dolutegravir|OTHER: Triple cART regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fasting Study of Glipizide and Metformin HCl Tablets 5 mg/500 mg to Metaglip® Tablets 5 mg/500 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Glipizide and Metformin HCl Tablets 5 mg/500 mg|DRUG: Metaglip® Tablets 5 mg/500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The RECHARGE Low Carbohydrate Diet Trial for Metastatic Cancer
Status: COMPLETED
Conditions: Cancer|Breast Cancer|Colon Cancer|Cervical Cancer|Uterine Cancer|Ovarian Cancer
Interventions: BEHAVIORAL: Very low carbohydrate diet (approximately 20 grams per day)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Trial of Lenvatinib (E7080) in 131I-Refractory Differentiated Thyroid Cancer (DTC)
Status: COMPLETED
Conditions: Thyroid Cancer
Interventions: DRUG: Lenvatinib|DRUG: Placebo|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety, Tolerability and Pharmacokinetics of ADC3680B in Subjects With Partly Controlled Atopic Asthma
Status: COMPLETED
Conditions: Atopic Asthma
Interventions: DRUG: ADC3680B oral|DRUG: Placebo oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Outpatient Medical Abortion With Mifepristone and Misoprostol Through 77 Days of Gestation
Status: COMPLETED
Conditions: Medical Abortion
Interventions: DRUG: Mifepristone followed by misoprostol 24-48 hours later
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and PK 3-Period Crossover Study Comparing 2 Single Doses of ZTI-01 and Monurol® in Healthy Subjects
Status: COMPLETED
Conditions: Pseudomonas Infection
Interventions: DRUG: Fosfomycin tromethamine|DRUG: Fosfomycin disodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Opioid-Experienced, Non-Dependent Recreational Drug Users to Determine the Abuse Potential and Safety of CL-108 Tablets Administered Via the Oral Route
Status: COMPLETED
Conditions: Pain|Nausea|Vomiting
Interventions: DRUG: CL-108|DRUG: M366|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload
Status: NOT_YET_RECRUITING
Conditions: Acute Heart Failure
Interventions: DRUG: Acetazolamide|DRUG: Metolazone 2.5 MG|OTHER: Double-placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study to Investigate the Skin Irritancy Potential of Diclofenac-Menthol Gel
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: 1% Diclofenac Sodium|DRUG: 3% Menthol|DRUG: 0.09% Menthol|DRUG: 0.2% Sodium Lauryl Sulfate|DRUG: 0.9% Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of Motexafin Gadolinium and Temozolomide for the Treatment of Malignant Gliomas
Status: COMPLETED
Conditions: Glioma|Glioblastoma|Astrocytoma|Oligodendroglioma|Brain Neoplasm
Interventions: DRUG: Motexafin Gadolinium Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Mass Balance, Metabolism, and Excretion of [14C]PF-07321332 in Healthy Male Participants.
Status: WITHDRAWN
Conditions: Healthy Participants
Interventions: DRUG: [14C]PF-07321332
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The HOP-STEP Intervention: Improving Maternal Health in Women With Lupus sIRB
Status: NOT_YET_RECRUITING
Conditions: Systemic Lupus Erythematosus|Contraception
Interventions: BEHAVIORAL: HOP-STEP (Healthy Outcomes in Pregnancy with SLE Through Education of Providers) Intervention|BEHAVIORAL: Routine Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Evaluate the Efficacy of Pravastatin on Survival and Recurrence of Advanced Gastroesophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Cancer|Stomach Cancer
Interventions: DRUG: Pravastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of Vigam® Liquid in Patients With Primary or Secondary Antibody Deficiency
Status: COMPLETED
Conditions: Primary or Secondary Antibody Deficiency
Interventions: BIOLOGICAL: Vigam® (Human Normal Immunoglobulin)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Mood Management Effects of Brief Unsupported Internet Interventions
Status: COMPLETED
Conditions: Mood
Interventions: BEHAVIORAL: Thoughts|BEHAVIORAL: Activities.|BEHAVIORAL: Assertiveness.|BEHAVIORAL: Sleep hygiene|BEHAVIORAL: Own Methods
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Veliparib and Irinotecan Hydrochloride in Treating Patients With Cancer That Is Metastatic or Cannot Be Removed by Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Hodgkin Lymphoma|Metastatic Malignant Neoplasm|Metastatic Malignant Solid Neoplasm|Non-Hodgkin Lymphoma|Stage III Breast Cancer AJCC v7|Stage III Colon Cancer AJCC v7|Stage III Lung Cancer AJCC v7|Stage III Ovarian Cancer AJCC v6 and v7|Stage III Pancreatic Cancer AJCC v6 and v7|Stage IIIA Breast Cancer AJCC v7|Stage IIIA Colon Cancer AJCC v7|Stage IIIA Ovarian Cancer AJCC v6 and v7|Stage IIIB Breast Cancer AJCC v7|Stage IIIB Colon Cancer AJCC v7|Stage IIIB Ovarian Cancer AJCC v6 and v7|Stage IIIC Breast Cancer AJCC v7|Stage IIIC Colon Cancer AJCC v7|Stage IIIC Ovarian Cancer AJCC v6 and v7|Stage IV Breast Cancer AJCC v6 and v7|Stage IV Colon Cancer AJCC v7|Stage IV Lung Cancer AJCC v7|Stage IV Ovarian Cancer AJCC v6 and v7|Stage IV Pancreatic Cancer AJCC v6 and v7|Stage IVA Colon Cancer AJCC v7|Stage IVB Colon Cancer AJCC v7|Triple-Negative Breast Carcinoma|Unresectable Malignant Neoplasm|Unresectable Solid Neoplasm
Interventions: DRUG: Irinotecan Hydrochloride|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Ibuprofen 200 mg Soft Gel Capsules of Dr. Reddy's Laboratories Limited Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MAD Trial: Myopia Atropine Dose
Status: RECRUITING
Conditions: Progressive Myopia
Interventions: DRUG: Atropine Ophthalmic 0.05%|DRUG: Atropine Ophthalmic 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Discovering New Insights Into Anorexia Nervosa: Influence of MicrObial DysbiosiS (DIAMOnDS)
Status: RECRUITING
Conditions: Anorexia Nervosa
Interventions: OTHER: Patients with severe to extreme anorexia nervosa admitted to hospital for refeeding
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pilot Study Assessing the Treatment Responsiveness of a Novel Osteoarthritis Stiffness Scale
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Naproxen Sodium (Aleve, BAY117031)|DRUG: Acetaminophen ER|DRUG: Celecoxib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SIM0278 in Chinese Healthy Subjects
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: SIM0278 Injection/Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dispensing Evaluation of Subjective Comfort, Vision, and Handling of a New Lens Compared to a Marketed Lens
Status: COMPLETED
Conditions: Refractive Ametropia
Interventions: DEVICE: etafilcon A with print and PVP for dark eyes (EAPVPDE)|DEVICE: etafilcon A control lens (EADE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Online Comprehensive Behavioral Intervention for Tics (CBIT) Therapist Training Program
Status: RECRUITING
Conditions: Tics|Tic Disorders|Tourette Syndrome
Interventions: BEHAVIORAL: Behavior Therapy Training Institute|BEHAVIORAL: CBIT-Trainer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Engaging Immigrants in Preventive Parenting Interventions
Status: COMPLETED
Conditions: Health Behavior|Parenting|Social Acceptance
Interventions: OTHER: Video Documentary entitled, "Para Sa Kinabukasan ng Mga Anak (For Our Children's Future)"|OTHER: Usual Care Video that is publicly available
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Ecological Effects of Decolonisation Strategies in Intensive Care
Status: COMPLETED
Conditions: ICU-ecology (Multidrug Resistant Bacteria)|ICU-acquired Bacteraemia
Interventions: DRUG: Chlorhexidine oral care (CHX-Oro)|DRUG: Selective oropharyngeal decontamination (SOD)|DRUG: Selective Digestive Decontamination (SDD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Preoperative Carbohydrate Rich Drinks on Immediate Postoperative Outcome in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Post Operative Nausea and Vomiting
Interventions: DIETARY_SUPPLEMENT: Nutricia preOp|OTHER: Nestle Splash Lemon Flavor Water (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose Range Study of CD5789 in Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: CD5789 25 µg/g cream|DRUG: CD5789 50 µg/g cream|DRUG: CD5789 100 µg/g cream|DRUG: Tazarotene 0.1% gel|DRUG: Vehicle cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Anesthesia on Perioperative Muscle Weakness and Neuro-endocrine Stress Response
Status: COMPLETED
Conditions: Muscle Weakness|Anesthesia|Anesthesia, Local|Surgery
Interventions: DRUG: General anesthesia|DRUG: Spinal anesthesia|DRUG: General anesthesia and epidural analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hyperbaric Oxygen Therapy for Pyoderma Gangrenosum
Status: NOT_YET_RECRUITING
Conditions: Pyoderma Gangrenosum
Interventions: DRUG: Hyperbaric oxygen|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Evaluation of a Motivational Interviewing Intervention Targeting Adherence Behaviors in Youth With Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: BEHAVIORAL: Adherence Treatment Program|BEHAVIORAL: Education only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Inulin and Arabinoxylan on Satiety, Energy/Food Intake and Changes in the Human Gut Microbiota
Status: UNKNOWN
Conditions: Overweight and Obesity
Interventions: OTHER: inulin|OTHER: arabinoxylan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EXERCISING TOGETHER for Couples Coping With Cancer
Status: COMPLETED
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Breast Carcinoma|Colorectal Carcinoma|Malignant Solid Neoplasm|Prostate Carcinoma|Stage I Colorectal Cancer AJCC v8|Stage I Prostate Cancer AJCC v8|Stage II Colorectal Cancer AJCC v8|Stage II Prostate Cancer AJCC v8|Stage III Colorectal Cancer AJCC v8|Stage III Prostate Cancer AJCC v8
Interventions: BEHAVIORAL: Exercise Intervention|BEHAVIORAL: Exercise Intervention|OTHER: Informational Intervention|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate Efficacy of Investigational Product HeezOn Ultra -1/ HeezOn Ultra-2 on Male Sexual Health
Status: COMPLETED
Conditions: Erectile Dysfunction|Premature Ejaculation
Interventions: OTHER: HeezOn Ultra-1|OTHER: HeezOn Ultra-2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Enzalutamide and LY3023414 in Men With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer Metastatic
Interventions: DRUG: LY3023414|DRUG: Enzalutamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II/III, Double-blind, Parallel Group Comparative Study of Oral Administration of NE-58095 Tablets
Status: COMPLETED
Conditions: Involutional Osteoporosis
Interventions: DRUG: NE-58095 IR|DRUG: NE-58095 IR Placebo|DRUG: NE-58095 DR|DRUG: NE-58095 DR Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of ATIR101 as Adjunctive Treatment to Blood Stem Cell Transplantation From a Haploidentical Family Donor Compared to Post-transplant Cyclophosphamide in Patients With Blood Cancer
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Myelodysplastic Syndrome
Interventions: BIOLOGICAL: ATIR101|DRUG: Cyclophosphamide|PROCEDURE: T-cell depleted HSCT from a related, haploidentical donor|PROCEDURE: T-cell replete HSCT from a related, haploidentical donor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies
Status: TERMINATED
Conditions: Immunologic Deficiency Syndromes|Chediak-Higashi Syndrome|Common Variable Immunodeficiency|Graft Versus Host Disease|X-Linked Lymphoproliferative Syndrome|Familial Erythrophagocytic Lymphohistiocytosis|Hemophagocytic Lymphohistiocytosis|X-linked Agammaglobulinemia|Wiskott-Aldrich Syndrome|Chronic Granulomatous Disease|X-linked Hyper IgM Syndrome|Severe Combined Immunodeficiency|Leukocyte Adhesion Deficiency Syndrome|Virus-Associated Hemophagocytic Syndrome
Interventions: DRUG: anti-thymocyte globulin|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: cyclosporine|DRUG: etoposide|DRUG: methotrexate|DRUG: methylprednisolone|DRUG: prednisone|PROCEDURE: Allogeneic Bone Marrow Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Efficacy of Lenvatinib as First-line Treatment in Participants With Unresectable HCC
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Examine the Effects of Low and High-fat Meals on Orally Administered Lapatinib in Metastatic ErbB2 Positive Breast Cancer Patients
Status: COMPLETED
Conditions: Neoplasms, Breast
Interventions: DRUG: Lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Metabolic Change in Prostate Cancer Bone Metastases on 68Ga-HBED-CC-PSMA PET/CT Following Radium-223 Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: radium-223 dichloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Durvalumab (MEDI4736) With or Without SBRT in Clinical Stage I, II and IIIA Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Durvalumab|OTHER: Durvalumab plus SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety and Efficacy of Emapalumab, an Anti-IFN-gamma mAb in Patients With Systemic Juvenile Idiopathic Arthritis (sJIA) or Adult-onset Still's Disease (AOSD) Developing Macrophage Activation Syndrome/Secondary HLH (MAS/sHLH)
Status: COMPLETED
Conditions: Macrophage Activation Syndrome|Lymphohistiocytosis, Hemophagocytic|Arthritis, Juvenile|Adult Onset Still Disease
Interventions: DRUG: Emapalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Study of Picosecond and Nanosecond Pulse Durations Using a Q-switched Nd:YAG Laser for Tattoo Removal
Status: COMPLETED
Conditions: Tattoo Removal
Interventions: DEVICE: enLighten Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Growth Hormone Feedback to Insulin-like Growth Factor-I (IGF-1) and Oral Glucose Tolerance Test (OGTT)
Status: COMPLETED
Conditions: Acromegaly|Type 2 Diabetes Mellitus
Interventions: DIAGNOSTIC_TEST: Oral Glucose Tolerance Test|DIAGNOSTIC_TEST: Subcutaneous administration of recombinant human IGF-1|DIAGNOSTIC_TEST: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Evaluation of a Management Strategy for Second-degree Fibrinous Burns Integrating a Poly-absorbent Dressing
Status: RECRUITING
Conditions: Burns Degree Second
Interventions: OTHER: Local treatment with silver sulphadiazine only|OTHER: Local treatment with silver sulphadiazine followed by URGOCLEAN® dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CLL-1 CAR-NK Cells for Relapsed/Refractory AML
Status: RECRUITING
Conditions: Relapsed Adult AML|Refractory AML
Interventions: DRUG: anti-CLL-1 CAR NK cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Financial Incentives and Text Messages to Improve Health Care in Population With Moderate and High Cardiovascular Risk
Status: UNKNOWN
Conditions: Moderate and High Cardiovascular Risk
Interventions: BEHAVIORAL: Financial incentives|BEHAVIORAL: Framing (SMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Association of Silicone Breast Implants With Overall Wellbeingand Auto-immune Diseases
Status: ENROLLING_BY_INVITATION
Conditions: Breast Cancer|Breast Implant; Complications|Autoimmune Diseases
Interventions: PROCEDURE: Breast reconstruction with silicone breast implant|PROCEDURE: Breast conserving surgery/Mastectomy/Autologous reconstruction|PROCEDURE: Breast Augmentation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Corn and Coconut Oils on Lipoprotein Lipids, Insulin Sensitivity and Inflammation
Status: COMPLETED
Conditions: Healthy Men and Women
Interventions: OTHER: Corn Oil|OTHER: Coconut Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sirolimus or Everolimus or Temsirolimus and Vorinostat in Advanced Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Cancer
Interventions: DRUG: Sirolimus|DRUG: Vorinostat|DRUG: Everolimus|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GutMe!: IBS and Collagen Protein Powder an Interventional Study
Status: COMPLETED
Conditions: Irritable Bowel Syndrome|Irritable Bowel|Irrit
Interventions: DIETARY_SUPPLEMENT: Collagen Protien Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Efficacy and Safety of BNX Sublingual Tablets for the Induction of Treatment of Opioid Dependence
Status: COMPLETED
Conditions: Opioid-Related Disorders|Opiate Dependence
Interventions: DRUG: Buprenorphine/naloxone sublingual tablets|DRUG: Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial Comparing Alfuzosin GITS 10 mg Daily With Placebo for Trial Without Catheter in Acute Urinary Retention With Long Term Follow up
Status: TERMINATED
Conditions: Prostatic Hyperplasia|Urinary Retention|Acute Disease
Interventions: DRUG: Alfuzosin GITS (Xatral XL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab Following TACE in Primary Liver Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Liver Carcinoma
Interventions: DRUG: Pembrolizumab|COMBINATION_PRODUCT: Trans-arterial chemoembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dolutegravir on Whole-body Insulin Sensitivity, Lipid and Endocrine Profile in Healthy Volunteers
Status: COMPLETED
Conditions: HIV-1-infection on Healthy Volunteers
Interventions: DRUG: Dolutegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pancreatic Anastomosis After Duodenopancreatectomy
Status: UNKNOWN
Conditions: Pancreatic Anastomotic Leak|Pancreatic Neoplasms
Interventions: PROCEDURE: Blumgart Anastomosis|PROCEDURE: Pancreatogastric anastomosis.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fasudil Eye Drop in Retinopathy Of Prematurity(ROP)
Status: UNKNOWN
Conditions: Retinopathy of Prematurity
Interventions: DRUG: Fasudil eye drops (concentration 0.5 percent)|DRUG: receive artificial tears drop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Dose-Optimization Study for the Initial Treatment of Dysplastic Barrett's Esophagus With trūFreeze™ Spray Cryotherapy
Status: TERMINATED
Conditions: Barrett's Esophagus
Interventions: DEVICE: trūFreeze™ Spray Cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Dose Exploration Clinical Trial Evaluating the Efficacy, Safety, and Pharmacokinetic Characteristics of STC314 Injection Administered Intravenously in Sepsis Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Sepsis
Interventions: DRUG: STC314 Injection/STC314 Injection Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study for Evaluating the SCIO Biofeedback Device's Ability to Increase Body Wellness After One 45-minute Session
Status: COMPLETED
Conditions: Stress
Interventions: DEVICE: Universal Electrophysiological Biofeedback Treatment|DEVICE: Universal Electrophysiological Biofeedback Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Cerebral Protection of Dexmedetomidine for Patients With Traumatic Brain Injury
Status: UNKNOWN
Conditions: Traumatic Brain Injury
Interventions: DRUG: Dexmedetomidine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Medication Adherence in Kidney Transplant Patients: SystemCHANGE™ Results of the Turkish MAGIC Randomized Clinical Trial
Status: COMPLETED
Conditions: Medication Adherence
Interventions: BEHAVIORAL: Behavioral: SystemCHANGE|OTHER: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Selective Radiation Dose Escalation and Tumour Hypoxia Status on Locoregional Tumour Control After Radiochemotherapy of HNT
Status: RECRUITING
Conditions: Locally Advanced Head and Neck Cancer
Interventions: RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of I-125 Brachytherapy Versus Intensity-modulated Radiation Therapy to Treat Inoperable Salivary Gland Cancer
Status: UNKNOWN
Conditions: Salivary Gland Cancer
Interventions: RADIATION: brachytherapy|RADIATION: IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study Evaluating the Safety and Efficacy of the Renal Stimulation by Direct Wire Pacing, During Renal Denervation Procedure
Status: NOT_YET_RECRUITING
Conditions: Essential Hypertension
Interventions: PROCEDURE: Renal Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Semaglutide on Pharmacokinetics and Pharmacodynamics of Warfarin and Pharmacokinetics of Metformin in Healthy Subjects
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2|Healthy
Interventions: DRUG: semaglutide|DRUG: placebo|DRUG: metformin|DRUG: warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Efficacy Study Of An Oral Tyrosine Kinase Inhibitor Of VEGFR-2 Given In Combination With Chemotherapy
Status: COMPLETED
Conditions: Lung Neoplasms
Interventions: DRUG: CP-547,632
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Omega-3 on Depression and Cognition
Status: ENROLLING_BY_INVITATION
Conditions: Depression
Interventions: DIETARY_SUPPLEMENT: omega-3|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protective Role of Inhaled Steroids for Covid-19 Infection
Status: TERMINATED
Conditions: Covid-19 Infection|Hospitalization in Respiratory Disease Department
Interventions: DRUG: 2: Usual practice + SYMBICORT RAPIHALER|OTHER: 1: Usual practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conformal Radiation Therapy in Treating Patients With Metastatic Cancer Outside the Brain
Status: TERMINATED
Conditions: Kidney Cancer|Melanoma (Skin)|Metastatic Cancer|Ovarian Cancer|Sarcoma|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: OTHER: questionnaire administration|RADIATION: 3-dimensional conformal radiation therapy|RADIATION: hypofractionated radiation therapy|RADIATION: image-guided radiation therapy|RADIATION: tomotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Effects of Odalasvir and AL-335 With Simeprevir on the Single-Dose Pharmacokinetics of Ethinylestradiol and Drospirenone in Healthy Female Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Drospirenone/ethinylestradiol|DRUG: AL-335|DRUG: Odalasvir (ODV)|DRUG: Simeprevir (SMV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Assess the Safety and Efficacy of Imiquimod 5% Cream for the Treatment of Actinic Keratosis on the Arms and Hands
Status: COMPLETED
Conditions: Keratosis
Interventions: DRUG: Aldara (imiquimod) cream, 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety & Efficacy of an Antibacterial Protein Molecule Applied Topically to the Nostrils of Volunteers and Patients
Status: COMPLETED
Conditions: Infectious Disease|Bacterial Infections
Interventions: DRUG: P128-0.1 mg|DRUG: P128-0.3 mg|DRUG: P128-1.0 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Validation of a Smartphone-based Recorder for Detection of Cardiac Arrhythmias
Status: UNKNOWN
Conditions: Cardiac Arrhythmia
Interventions: DEVICE: Alivecor recording
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Idalopirdine in Patients With Mild - Moderate Alzheimer's Disease Treated With an Acetylcholinesterase Inhibitor
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Placebo|DRUG: Idalopirdine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Arm Cycling in Facioscapulohumeral Dystrophy (FSHD) Patients
Status: COMPLETED
Conditions: Facioscapulohumeral Muscular Dystrophy
Interventions: OTHER: Arm cycling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcatheter Tricuspid Valve Interventions and Right Ventricular Function: Evaluation With Magnetic Resonance Imaging
Status: RECRUITING
Conditions: Tricuspid Valve Insufficiency
Interventions: DIAGNOSTIC_TEST: Magnet resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: OPTIMAl Endovascular Exclusion of Consecutive Patient High-risk Carotid Plaque Using the MicroNet Covered Stent
Status: UNKNOWN
Conditions: Carotid Artery Diseases
Interventions: DIAGNOSTIC_TEST: Intravascular Utrasound (IVUS) of Carotid Artery after implantation of CGuard stent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Compare Neoadjuvant Chemotherapy of DOS Versus SOX in Locally Advanced Gastric Adenocarcinoma.
Status: UNKNOWN
Conditions: Gastric Adenocarcinoma
Interventions: DRUG: Docetaxel|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential Hypofractionated Radiotherapy Followed by Anti-PD-L1 Atezolizumab for SCLC
Status: UNKNOWN
Conditions: Small Cell Lung Cancer Recurrent
Interventions: DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Glucose Predictive and Therapy Advisory System - DIAdvisor 2
Status: COMPLETED
Conditions: Diabetes Mellitus|Diabetes Mellitus, Type 2|Diabetes Mellitus, Type 1
Interventions: DEVICE: Personalized Glucose Predictive and Therapy Advisory System (DIAdvisor)|DEVICE: Personalized Glucose Predictive and Therapy Advisory System (DIAdvisor)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Aspergillus Niger Prolyl Endoprotease (AN-PEP) Enzyme on the Effects of Gluten Ingestion in Patients With Coeliac Disease
Status: COMPLETED
Conditions: Celiac Disease
Interventions: DIETARY_SUPPLEMENT: Aspergillus niger prolyl endoprotease|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Feeding Frequency on Glucose and Insulin Metabolism and Substrate Partitioning in Impaired Glucose Tolerant (IGT) Men
Status: COMPLETED
Conditions: Glucose Intolerance
Interventions: DIETARY_SUPPLEMENT: low feeding frequency (3x)|DIETARY_SUPPLEMENT: High feeding frequency (14x)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Extracorporeal Photopheresis in Children and Young Adults With Refractory Acute Graft Versus Host Disease
Status: UNKNOWN
Conditions: Graft Versus Host Disease
Interventions: PROCEDURE: ECP (performed on Themos UVAR-XTS or external UVA irradiator after cell collection by apheresis)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Better Sleep in Psychiatric Care - Depression, Anxiety and PTSD
Status: ACTIVE_NOT_RECRUITING
Conditions: Sleep Problem|Anxiety Disorders|Affective Disorder
Interventions: BEHAVIORAL: Adjusted group CBT-i for Depression, Anxiety and PTSD|OTHER: Care as usual wait-list control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nutritional Intervention to Prevent Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: DHA Treatment|DIETARY_SUPPLEMENT: Placebo for DHA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION