pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Perioperative Hypothermia in Patients Submitted to Laparoscopic Urological Surgery
Status: COMPLETED
Conditions: Hypothermia; Anesthesia|Anesthesia; Adverse Effect|Peroperative Complication|Postoperative Complications|Surgical Site Infection|Temperature Change, Body
Interventions: PROCEDURE: Preoperative warming
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: taVNS Application Timing During Robotic Sensorimotor Task
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DEVICE: in-house developed transcutaneous auricular Vagus Nerve Stimulation device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: TAXUS ATLAS: TAXUS Liberté™-SR Stent for the Treatment of de Novo Coronary Artery Lesions
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: TAXUS Liberté-SR|DEVICE: TAXUS™ Express
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CORset Versus OstéoSynthese in Adult Pyogenic Spondylodiscitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Spondylodiscitis
Interventions: DEVICE: Percutaneous instrumentation of the thoracolumbar spine|OTHER: Brace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Compression Headphone Study
Status: TERMINATED
Conditions: Hearing Loss
Interventions: DEVICE: Receiver-in-canal hearing aid 1 default|DEVICE: Receiver-in-canal hearing aid 2|DEVICE: Receiver-in-canal hearing aid 1 strategy 1|DEVICE: Receiver-in-canal hearing aid 1 strategy 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SOLMANIA - Comparison of Valproate-Amisulpride and Valproate-Haloperidol in Bipolar I Patients
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Amisulpride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supporting Patient Decisions About UE Surgery in Cervical SCI
Status: COMPLETED
Conditions: Cervical Spinal Cord Injury
Interventions: OTHER: Semi-structured interview|OTHER: Spinal Cord Independence Measure (SCIM-SR)|OTHER: SF-36
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety, Pharmacokinetics and Anti-Tumor Activity of ABBV-176 in Subjects With Advanced Solid Tumors Likely to Express Prolactin Receptor (PRLR)
Status: TERMINATED
Conditions: Advanced Solid Tumors Cancer
Interventions: DRUG: ABBV-176
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxytocin MEG Study
Status: COMPLETED
Conditions: Schizophrenia|Oxytocin|Magnetoencephalography (MEG)|Social Cognition
Interventions: DRUG: Oxytocin|DRUG: Saline Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Radiography in Detection of Recurrent Caries Underneath Chlorhexidine Containing Adhesive Versus Conventional Adhesive After One Year Follow up: Randomized Clinical Trial
Status: COMPLETED
Conditions: Recurrent Caries Incidence
Interventions: PROCEDURE: adhesive bond with chlorhexidine|OTHER: Time variable
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: REgenerative CardiOsphere iNjection to STRengthen dysfUnCTional Hearts
Status: WITHDRAWN
Conditions: Ischemic Cardiomyopathy|Chronic Ischemic Cardiomyopathy
Interventions: BIOLOGICAL: Endomyocardial injections of allogeneic Human CSps|BIOLOGICAL: Endomyocardial injections of vehicle only.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety/Efficacy of Letrozole Monotherapy or in Combination With Zoledronic Acid as Extended Adjuvant Treatment of Postmenopausal Patients With Primary Breast Cancer
Status: COMPLETED
Conditions: Osteoporosis|Postmenopausal
Interventions: DRUG: Letrozole|DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Pre-Malignant Lesions In Pediatric Patients With Neurofibromatosis Type 1 Using Novel Magnetic Resonance Imaging Techniques Paired With Artificial Intelligence
Status: RECRUITING
Conditions: Neurofibromatosis Type 1
Interventions: OTHER: Whole-body Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Intra-operative Autologous Retropubic Urethral Sling on Urinary Control After Robot Assisted Radical Prostatectomy
Status: COMPLETED
Conditions: Men With Prostate Cancer Undergoing Robot Assisted Radical Prostatectomy
Interventions: PROCEDURE: Placement of sling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Min Implants Max Outcomes Clinical Trial
Status: COMPLETED
Conditions: Scoliosis|Adolescent Idiopathic Scoliosis
Interventions: PROCEDURE: Maximum Number of Screws|PROCEDURE: Minimum Number of Screws
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Suture Techniques to Reduce the Incidence of The inCisional Hernia
Status: COMPLETED
Conditions: Hernia|Wound Infection|Burst Abdomen|Pain|Quality of Life
Interventions: PROCEDURE: Closure of the abdominal wall after midline incisions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of HCD122 (Lucatumumab) and Bendamustine Combination Therapy in CD40+ Rituximab-refractory Follicular Lymphoma
Status: COMPLETED
Conditions: Follicular Lymphoma
Interventions: DRUG: HCD122
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myoinositol Treatment and Asprosin Levels in PCOS
Status: COMPLETED
Conditions: PCOS|Insulin Resistance
Interventions: DRUG: inofolic combi|DRUG: Glucophage 500Mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Acarbose on Postprandial Lipoprotein Levels in Glucose Intolerant Patients
Status: COMPLETED
Conditions: Glucose Intolerance|Postprandial Hyperglycemia|Cardiovascular Risk Factor
Interventions: DRUG: Acarbose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Study to Assess MultiStem® Therapy in Acute Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome
Interventions: BIOLOGICAL: MultiStem|BIOLOGICAL: MultiStem|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of BAFFR CART for Relapsed/ Refractory Neuromyelitis Optica Spectrum Disorder
Status: NOT_YET_RECRUITING
Conditions: Neuromyelitis Optica Spectrum Disorder
Interventions: DRUG: Anti-BAFFR CART
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Salicylic Augmentation in Depression
Status: TERMINATED
Conditions: Depression|Depressive Disorder|Major Depressive Disorder|Treatment Resistant Depression
Interventions: DRUG: Aspirin 325mg|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Test a Marketed Drug in the Treatment of Menstrual Migraine (0462-071)
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: MK0462, rizatriptan benzoate / Duration of Treatment -1 day|DRUG: Comparator: placebo / Duration of Treatment - 1 day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Regulation of Lipid Metabolism in Guangzhou Individuals With Dyslipidemia by Red Yeast Rice, Phytosterol Esters and Lycopene
Status: ENROLLING_BY_INVITATION
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: Swisse plus cholesterol capsule|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect on Small Airways of Addition of Theophylline as Inducer of Histone Deacilase Activity for Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD), Treated With Inhaled Steroids and Long Acting Beta Agonists
Status: UNKNOWN
Conditions: COPD
Interventions: DRUG: Theophylline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanisms for Dyspnea on Exertion in Children With Obesity and Asthma: Distinct Physiological Phenotypes
Status: WITHDRAWN
Conditions: Asthma in Children|Dyspnea; Asthmatic|Obesity, Childhood
Interventions: OTHER: Control|DRUG: Albuterol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Dexmedetomidine on Microcirculation of Kidney Transplant Recipient
Status: COMPLETED
Conditions: Kidney Disease
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Brigatinib in Pediatric and Young Adult Patients With ALK+ ALCL, IMT or Other Solid Tumors
Status: RECRUITING
Conditions: Anaplastic Large Cell Lymphoma, ALK-Positive|Inflammatory Myofibroblastic Tumor|Other Solid Tumor
Interventions: DRUG: Brigatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Randomised Study of Interferon-free Treatment for Recently Acquired Hepatitis C in PWID and People With HIV Coinfection.
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: SOF/VEL for 6 weeks|DRUG: SOF/VEL for 12 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Blinded, Four-Way Crossover in Healthy Subjects to Assess EEG After Administration of Ketamine, Placebo and AZD6765
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: AZD6765|DRUG: AZD6765|DRUG: Ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Activity of TroVax® Alone vs. TroVax® Plus GM-CSF in Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: BIOLOGICAL: TroVax|DRUG: GM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on Changes in IFN-gamma Levels Following Anti-TNF Treatment in Patients Undergoing Serial QuantiFERON-TB Gold In-Tube
Status: COMPLETED
Conditions: Inflammatory Rheumatic Diseases
Interventions: BIOLOGICAL: QuantiFERON-TB Gold In-Tube (QFT-GIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Trial of SB-061 in Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: SB-061|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study to Investigate the Kinetics of the Immune Response Generated by Influenza Virus Vaccine.
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: CAIV-T|BIOLOGICAL: TIV|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: NAC Supplementation and Skeletal Muscle Performance
Status: COMPLETED
Conditions: Skeletal Muscle Damage|Skeletal Muscle Performance|Intgracellular Signaling in Skeletal Muscle|Inflammatory Status
Interventions: DIETARY_SUPPLEMENT: n-acetylcysteine supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Rotational Atherectomy Prior to Taxus Stent
Status: COMPLETED
Conditions: Complex Calcified Coronary Lesions
Interventions: PROCEDURE: Rotational Atherectomy + PES|PROCEDURE: Standard Treatment (PES without Rotational Atherectomy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Study of Two Different Surgical Clips During Laparoscopic Urologic Surgery
Status: TERMINATED
Conditions: Prostatectomy|Nephrectomy|Laparoscopy|Robotics
Interventions: DEVICE: Teleflex HemoLock clip|DEVICE: Aesculap U-clip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effect of Coffee and Agave Inulin-based Beverage on Appetite in Adults With Obesity.
Status: ENROLLING_BY_INVITATION
Conditions: Obesity
Interventions: OTHER: Coffee and agave inulin-based beverage (A)|OTHER: Control beverage (B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Randomized Trial to Evaluate the Effectiveness of Transferring the Flexor Hallucis Longus Tendon
Status: UNKNOWN
Conditions: Achilles Tendinopathy
Interventions: PROCEDURE: Flexor Hallucis Longus Tendon transfer|PROCEDURE: Transfer of the Flexor Hallucis Longus Tendon|PROCEDURE: No transfer of Flexor Hallucis Longus tendon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Myofascial and Articular Treatment of Adolescent Idiopathic Scoliosis
Status: COMPLETED
Conditions: Scoliosis Idiopathic Adolescent Treatment
Interventions: OTHER: Dynamic myofascial manipulation|OTHER: Standard AIS treatment with observation or bracing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Tolerability of ABBV-621 in Participants With Previously-Treated Solid Tumors and Hematologic Malignancies
Status: COMPLETED
Conditions: Advanced Solid Tumors|Cancer|Hematologic Malignancies
Interventions: DRUG: ABBV-621|DRUG: Venetoclax|DRUG: Bevacizumab|DRUG: FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-ranging Study of Rifaximin Soluble Solid Dispersion (SSD) Tablets for the Prevention of Complications of Early Decompensated Liver Cirrhosis
Status: COMPLETED
Conditions: Liver Cirrhosis
Interventions: DRUG: Placebo|DRUG: Rifaximin SSD 40 mg IR tablet|DRUG: Rifaximin SSD 80 mg IR tablet|DRUG: Rifaximin SSD 40 mg SER tablet|DRUG: Rifaximin SSD 80 mg SER tablet|DRUG: Rifaximin SSD 80mgIR/80mgSER tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study to Assess the Effects of SRT2104 Upon Immobilization-Induced Skeletal Muscle Atrophy in Healthy Human Volunteers
Status: WITHDRAWN
Conditions: Healthy Volunteer|Atrophy, Muscular
Interventions: DRUG: Placebo|DRUG: SRT2104
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of RIC in Pediatric Moyamoya Disease Patients Treated With Revascularization Therapy
Status: UNKNOWN
Conditions: Moyamoya Disease|Pediatric
Interventions: DEVICE: RIC group|DEVICE: sham group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial Investigating the Long Term Safety and Tolerability of Desmopressin Orally Disintegrating Tablets (ODT) for Nocturia Due to Nocturnal Polyuria in Japanese Subjects
Status: COMPLETED
Conditions: Nocturia
Interventions: DRUG: Desmopressin ODT 25 μg|DRUG: Desmopressin ODT 50 μg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Exufiber Ag+ and Other Gelling Fibre Dressings
Status: COMPLETED
Conditions: Wounds and Injuries
Interventions: DEVICE: Exufiber Ag+|DEVICE: Exufiber|DEVICE: Aquacel Ag Extra
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SMART Embedded Intervention for Military Postsurgical Engagement Readiness
Status: RECRUITING
Conditions: Knee Pain Chronic
Interventions: BEHAVIORAL: Brief mindfulness|BEHAVIORAL: Mindfulness-Oriented Recovery Enhancement (MORE)|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zanubrutinib and Tafasitamab in Mantle Cell Lymphoma
Status: RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Zanubrutinib|DRUG: Tafasitamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Determine the Safety and Tolerability of Transplanted Stem Cell Derived Dopamine Neurons to the Brains of Individuals With Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: BIOLOGICAL: STEM-PD
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Low Level Laser Therapy on Insulin Resistance and Inflammatory Biomarkers
Status: COMPLETED
Conditions: Insulin Resistance|Inflammatory Markers
Interventions: DEVICE: low level laser in addition to diet recommendations|OTHER: sham laser application in addition to diet recommendations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluate the Efficacy and Safety of Ruxolitinib on Hair Regrowth in Patients With Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)-Associated Alopecia Areata
Status: RECRUITING
Conditions: Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (Apeced)|Alopecia Areata
Interventions: DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare Dose Regimens of AllerT, in Adults With Allergic Rhino-Conjunctivitis to Birch Pollen Studied in EEC
Status: COMPLETED
Conditions: Allergic Rhino-Conjunctivitis
Interventions: DRUG: AllerT|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sugammadex and Neostigmine at Shallow Neuromuscular Blockade
Status: COMPLETED
Conditions: Neuromuscular Block
Interventions: DRUG: Sugammadex, Neostigmine, Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Induction and Maintenance Treatment of Advanced or Metastatic Non Squamous Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small-Cell Lung Cancer
Interventions: DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Avian Flu Vaccine
Status: COMPLETED
Conditions: Influenza A Virus, H5N1 Subtype|Influenza A Virus|Influenzavirus A|Orthomyxoviridae|H5N1 Virus
Interventions: DRUG: VRC-AVIDNA036-00-VP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adolescents With Major Depressive Disorder Who Have an Inadequate Response to Selective Serotonin Reuptake Inhibitor (SSRI) and Psychotherapy
Status: TERMINATED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Seltorexant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Can the SpotOn™ Zero-Heat-Flux-Thermometry Sensor Accurately Measure Core Temperature in Children?
Status: COMPLETED
Conditions: Hypothermia; Anesthesia|Hypothermia Following Anesthesia|Children
Interventions: DEVICE: Thermometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Effect of 2 Dosage Strengths of Lemborexant (E2006) on a Multiple Sleep Latency Test in Participants With Insomnia Disorder
Status: COMPLETED
Conditions: Insomnia Disorder
Interventions: DRUG: Lemborexant 5 mg|DRUG: Lemborexant 10 mg|DRUG: Lemborexant-matched placebo.|DRUG: Flurazepam 30 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Colonization of Skin by M. Luteus Q24 Probiotic
Status: ACTIVE_NOT_RECRUITING
Conditions: Microbial Colonization
Interventions: OTHER: Active Comparator: Study Group A: Blis Q24 Serum at higher dose|OTHER: Active Comparator: Study Group B: Blis Q24 Serum at lower dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Your Health Matters! (Tu Salud ¡Si Cuenta!): Promoting Healthy Lifestyles in Latino Families
Status: ACTIVE_NOT_RECRUITING
Conditions: Family Member|Health Status Unknown
Interventions: OTHER: Behavioral, Psychological or Informational Intervention|OTHER: Behavioral, Psychological or Informational Intervention|BEHAVIORAL: Patient Visit|OTHER: Questionnaire Administration|OTHER: Text Message|OTHER: Text Message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vinblastine +/- Bevacizumab in Children With Unresectable or Progressive Low Grade Glioma (LGG)
Status: ACTIVE_NOT_RECRUITING
Conditions: Low Grade Glioma
Interventions: DRUG: Vinblastine|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preliminary Evaluation of Two Rapid Diagnostic Test Prototypes for Strongyloides Stercoralis Infection
Status: NOT_YET_RECRUITING
Conditions: Strongyloides Stercoralis Infection
Interventions: DIAGNOSTIC_TEST: IgG RDT|DIAGNOSTIC_TEST: IgG4 RDT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: MR-linac Guided Adaptive Radiotherapy for Inoperable Mediastinal Tumor
Status: UNKNOWN
Conditions: Mediastinal Tumor
Interventions: COMBINATION_PRODUCT: Unity-based MR-Linac guided Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Respiratory Motion-Corrected Cone-Beam CT and Intratreatment Gating Based on Electromagnetic Transponders to Reduce Target Position Uncertainty in Radiation Treatment of Lung Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer
Interventions: PROCEDURE: Bronchoscopic Implantation|DEVICE: Cone-Beam CT-Guided|RADIATION: stereotactic body radiation treatments
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Improving Medication Adherence in Pediatric Inflammatory Bowel Disease
Status: COMPLETED
Conditions: Crohn's Disease|Ulcerative Colitis|Indeterminate Colitis|Inflammatory Bowel Disease
Interventions: BEHAVIORAL: Telehealth Behavioral Treatment (TBT)|BEHAVIORAL: Education Only (EO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Gleevec in Patients With Idiopathic Myelofibrosis or Chronic Myelomonocytic Leukemia (CMML)
Status: COMPLETED
Conditions: Myelofibrosis|Myeloid Metaplasia|Agnogenic Myeloid Metaplasia|Chronic Myelomonocytic Leukemia
Interventions: DRUG: Imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implant Retained Rehabilitation With Surgical and Prosthetic Digital Workflow
Status: ACTIVE_NOT_RECRUITING
Conditions: Jaw, Edentulous, Partially
Interventions: DEVICE: Neodent GM Helix Implant|DEVICE: GM Customizable Healing Abutment|DEVICE: GM Pro PEEK Abutment|DEVICE: GM Exact Titanium Base
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Multimodal Exercises and Education Tele-Rehabilitation (MEET-R) for Low Back Pain Managment
Status: NOT_YET_RECRUITING
Conditions: Non-specific Low Back Pain
Interventions: OTHER: Multimodal Exercises and Education delivered through tele rehabilitation|OTHER: Selafcare
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Melatonin in Patients With Severe Sepsis or Septic Shock
Status: UNKNOWN
Conditions: Severe Sepsis|Septic Shock
Interventions: DRUG: Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Stable Glucagon Analog Administered by a Bihormonal Closed Loop System
Status: WITHDRAWN
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Dasiglucagon|DRUG: GlucaGen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Search for Viral and Bacterial Etiology of Varicocele
Status: UNKNOWN
Conditions: Varicocele|Viral Infection|Bacterial Infections|Sonic Hedgehog Expression|VEGF Expression
Interventions: PROCEDURE: subinguinal microscopic varicocelectomy|PROCEDURE: open hernia repair
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Glucagon Like Peptide-1(GLP-1) and Liraglutide on Brain Satiety and Reward Circuits and Feeding Behavior in Diabetes
Status: COMPLETED
Conditions: Obesity|Type 2 Diabetes
Interventions: DRUG: Liraglutide treatment 12 weeks|DRUG: insulin glargine treatment|DRUG: GLP-1 receptor antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Pilot Trial to Assess Low-Intensity Ultrasound in Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Degenerative
Interventions: DEVICE: Pulsed Low Intensity Ultrasound|DEVICE: Sham Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PD-L1/PD-1 Inhibitors Plus Chemotherapy Versus Chemotherapy Alone for the Neoadjuvant Treatment of Limited-stage SCLC
Status: NOT_YET_RECRUITING
Conditions: Limited-stage Small-cell Lung Cancer
Interventions: DRUG: Tislelizumab|DRUG: Carboplatin injection|DRUG: Cisplatin injection|DRUG: Etoposide injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acetylsalicylic Acid and Colorectal Cancer Prevention: Exploring the Platelet Function of Its Mechanism of Action
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: Acetylsalicylic acid|PROCEDURE: Screening colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CHOICE OF SUBJECTIVE OCULAR REFRACTION TECHNIQUE AND CORNEAL TOPOGRAPHY OF KERATOCONUS
Status: COMPLETED
Conditions: Keratoconus|Alteration of Visual Acuity
Interventions: BEHAVIORAL: Cylinder|BEHAVIORAL: Dial|BEHAVIORAL: Slit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pancreatic Metal Stents in Chronic Pancreatitis
Status: COMPLETED
Conditions: Refractory Pancreatic Duct Strictures|Painful Chronic Pancreatitis
Interventions: DEVICE: WallFlex Pancreatic Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect Of NS-0200 Versus Placebo On Hepatic Fat Content In Patients With Non Alcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: NAFLD
Interventions: DRUG: Leu-Met-Sil 0.5|DRUG: Leu-Met-Sil 1.0|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: D-Cycloserine to Enhance Extinction to Alcohol Cues
Status: COMPLETED
Conditions: Alcohol Use Disorders.
Interventions: DRUG: d-cycloserine.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prevalence of High Plasmatic 3OMethyldopa Level in a Specific Population of Patients With a Symptomatology Compatible With AADC Deficiency
Status: RECRUITING
Conditions: Aromatic L-Amino Acid Decarboxylase Deficiency
Interventions: DIAGNOSTIC_TEST: Plasmatic 3-O-Methyldopa dosage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety & Immunogenicity Study of Ad5 Based Oral Norovirus Vaccines
Status: COMPLETED
Conditions: Norovirus Infection
Interventions: BIOLOGICAL: VXA-G1.1-NN|BIOLOGICAL: VXA-G2.4-NS|BIOLOGICAL: Placebo Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Non-ischemic Cardiomyopathies by Intravenous Extracellular Vesicles of Cardiovascular Progenitor Cells
Status: RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: BIOLOGICAL: Extracellular vesicle-enriched secretome of cardiovascular progenitor cells differentiated from induced pluripotent stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real Clinical Practice Register of AlbUminuRia Detection in Patients With Previously undiAgnosed Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Hypertension|Chronic Heart Failure|Ischemic Heart Disease|Atrial Fibrillation|PreDiabetes|Chronic Obstructive Pulmonary Disease|Cancer|Urolithiasis|COVID-19
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy/Safety of Pseudoephedrine Plus Levocetirizine Versus Placebo in Patients With Vasomotor Rhinitis
Status: COMPLETED
Conditions: Vasomotor Rhinitis
Interventions: DRUG: Pseudoephedrine / Levocetirizine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GentleCath Air (Urinary Self-catheterization) - Pain in Female Patients With Neurological Vesico-sphincter Disorders
Status: WITHDRAWN
Conditions: Spinal Cord Injuries|Multiple Sclerosis|Parkinsonian Disorders|Allodynia
Interventions: DEVICE: GentleCath™ Air catheter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Subcutaneous Atezolizumab for the Treatment of Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Lung Non-Small Cell Carcinoma|Stage II Lung Cancer AJCC v8|Stage IIA Lung Cancer AJCC v8|Stage IIB Lung Cancer AJCC v8|Stage III Lung Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8|Stage IIIB Lung Cancer AJCC v8|Stage IIIC Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: BIOLOGICAL: Atezolizumab and Recombinant Human Hyaluronidase|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation on the Epidemic Prevention Effect of Using Chinese Medicine During the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Outbreak.
Status: COMPLETED
Conditions: COVID-19 Pandemic
Interventions: DRUG: Jing-Guan-Fang(JGF) : Chinese herbal decoction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Isatuximab in Combination With Rd Compared to Rd in Elderly Patients (Aged ≥70 Years) With NDMM
Status: RECRUITING
Conditions: Newly Diagnosed Multiple Myeloma
Interventions: DRUG: Isatuximab-Irfc 20 MG/ML [Sarclisa]|DRUG: Lenalidomide|DRUG: Dexamethasone Oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fusion Protein rHSA/GCSFclinical Study on Breast Cancer Patients
Status: COMPLETED
Conditions: Chemotherapy-induced Neutropenia|Cancer, Breast
Interventions: DRUG: rHSA/GCSF|DRUG: rHSA/GCSF|DRUG: rHSA/GCSF|DRUG: rHSA/GCSF|DRUG: rHSA/GCSF|DRUG: rHSA/GCSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Subcutaneous Hyaluronidase Administration on Psoriatic Plaques
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Hylenex|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of CNTY-101 in Participants With CD19-Positive B-Cell Malignancies
Status: RECRUITING
Conditions: R/R CD19-Positive B-Cell Malignancies|Indolent Non-Hodgkin Lymphoma|Aggressive Non-Hodgkin Lymphoma
Interventions: BIOLOGICAL: CNTY-101|BIOLOGICAL: IL-2|DRUG: Lymphodepleting Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Treadmill Training in Individuals With Traumatic Brain Injury
Status: RECRUITING
Conditions: Traumatic Brain Injury
Interventions: DEVICE: C-Mill with AR/VR Guidance|DEVICE: C-Mill without AR/VR Guidance|DEVICE: Zeno 3-Layer Walkway|DEVICE: Hunova
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LEGO MRI: Decreasing the Need for Sedation, and Improving Patient Anxiety.
Status: WITHDRAWN
Conditions: Stress|Anesthesia|Children, Only|Anxiety|MRI|Sedation
Interventions: OTHER: LEGO Bricks MRI|OTHER: Mock MRI tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Nebivolol on Endothelial Dysfunction in African Americans With Hypertension
Status: COMPLETED
Conditions: High Blood Pressure
Interventions: DRUG: Nebivolol|DRUG: Metoprolol XL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-Exposure Prophylaxis Dosing in Pregnancy to Optimize HIV Prevention (PREP-P)
Status: WITHDRAWN
Conditions: Pregnancy|HIV-1-infection
Interventions: DRUG: Standard dose Truvada®|DRUG: Pregnancy-adjusted dose Truvada®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - Hemodynamics (CREST-H)
Status: ACTIVE_NOT_RECRUITING
Conditions: Internal Carotid Artery Stenosis|Cognitive Impairment
Interventions: PROCEDURE: Revascularization|OTHER: Intensive Medical Management (IMM) alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Injectable Naltrexone Treatment of Alcohol Dependence in Serious Mental Illness (SMI)
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Bipolar Disorder|Alcohol Dependence
Interventions: DRUG: long-lasting injectable naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of PCSK9 Inhibitors on Calcific Aortic Valve Stenosis
Status: RECRUITING
Conditions: Aortic Stenosis
Interventions: DRUG: PCSK9 inhibitors and statins with or without ezetimibe|DRUG: Statins with or without ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Icapamespib (PU-AD) in Patients With Recurrent Malignant Glioma
Status: TERMINATED
Conditions: Recurrent Glioblastoma Multiforme (GBM)|Grade 3 Isocitrate Dehydrogenase (IDH) Wildtype Astrocytoma|Grade 3 or 4 Astrocytoma|Glioblastoma Surgery
Interventions: DRUG: Icapamespib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Immune Maintenance Therapy for Esophageal Squamous Cell Carcinoma After Radical Resection
Status: NOT_YET_RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma Thoracic Stage II|Esophageal Squamous Cell Carcinoma Thoracic Stage III|Esophageal Squamous Cell Carcinoma Thoracic Stage IV
Interventions: DRUG: sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: CIML NK Cells With Venetoclax for AML
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Acute Myeloid Leukemia Recurrent|Leukemia|Leukemia, Myeloid
Interventions: BIOLOGICAL: Cytokine-Induced Memory-like Natural Killer Cells|BIOLOGICAL: Interleukin-2|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Healthy Lifestyle Behaviors in Schoolchildren: an Online Video Intervention for Parents
Status: COMPLETED
Conditions: Physical Activity|Sedentary Behavior|Healthy Diet|Primary Schoolchildren|Parents|Parenting
Interventions: BEHAVIORAL: Movie Models
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Interleukin-1 Blockade in Recently Decompensated Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Anakinra (weeks 1-2)|DRUG: Anakinra (weeks 3-12)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrome
Status: COMPLETED
Conditions: Cushing Syndrome
Interventions: DRUG: Relacorilant|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: KAVIAR Study - Kyphoplasty And Vertebroplasty In the Augmentation and Restoration of Vertebral Body Compression Fractures
Status: TERMINATED
Conditions: Vertebral Body Compression Fractures
Interventions: PROCEDURE: Vertebroplasty|PROCEDURE: Kyphoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating Zenocutuzumab in Patients With or Without Molecularly Defined Cancers
Status: RECRUITING
Conditions: NSCLC Harboring NRG1 Fusion|Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: Afatinib Oral Tablet|DRUG: Enzalutamide Pill|DRUG: Abiraterone acetate tablets|BIOLOGICAL: MCLA-128
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Media Use in Preschooler Study (MUPS)
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Strategies to decrease screen time in children|BEHAVIORAL: Non-Strategical Media Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Peripheral Blood Multi-Omics Study on Sleep Loss
Status: RECRUITING
Conditions: Sleep Deprivation|Aging|Alzheimer Disease|Healthy Lifestyle|Cognitive Decline|Shift-work Disorder
Interventions: BEHAVIORAL: Experimental sleep deprivation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Promoting Inclusive Educational Environments for Children With Autism and Other Social-communication Challenges: Preschool Class and Primary School
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Social Communication Challenges
Interventions: BEHAVIORAL: APERS-based model
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Study to Assess a Dietary Supplement on Sleep Health and Quality
Status: COMPLETED
Conditions: Sleep Quality|Sleep Health
Interventions: DIETARY_SUPPLEMENT: Sleep Supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Motor Excitability Study of High Definition Transcranial Direct Current Stimulation (HD-tDCS) in Chronic Stroke
Status: RECRUITING
Conditions: Stroke
Interventions: DEVICE: HD-tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Phase II Trial of a PD-1 Inhibitor INCMGA00012 as Consolidation Therapy After Definitive Concurrent Chemoradiotherapy(RHAPSODY)
Status: NOT_YET_RECRUITING
Conditions: Esophageal Cancer
Interventions: DRUG: INCMGA00012
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A New Technique to Produce Anatomical Alignment Results With Less Midflexion Instability in Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: Implantation of TKA using the gap technique|PROCEDURE: Implantation of TKA using anatomical alignment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zinc for the Treatment of Herpes Simplex Labialis (HSL)
Status: COMPLETED
Conditions: Herpes Simplex Labialis
Interventions: DRUG: Zicam (Ionic zinc)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Simulation Training in the Pediatric Tracheostomy and Home Ventilator Population
Status: ACTIVE_NOT_RECRUITING
Conditions: Tracheostomy Complication|Simulation of Physical Illness|Teach-Back Communication
Interventions: BEHAVIORAL: Simulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Palbociclib and Pembrolizumab in Undifferentiated Pleomorphic Sarcoma (UPS)
Status: RECRUITING
Conditions: Undifferentiated Pleomorphic Sarcoma
Interventions: DRUG: Palbociclib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of AZD4877 (a Novel Anti-mitotic Agent) in Advanced Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer|Transitional Cell Bladder Cancer|Urethra Cancer|Ureter Cancer|Renal Pelvis Cancer
Interventions: DRUG: AZD4877
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT