pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Validation of the Turkish Version of PTSD-RI-5
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder in Children
Interventions: OTHER: Testing the the DSM-5 UCLA Posttraumatic Stress Disorder Reaction Index Self-Report Scale for Children and Adolescents (PTSD-RI-5)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sorafenib in Treating Patients With Angiosarcoma That is Locally Advanced, Metastatic, or Unable to Be Removed by Surgery
Status: UNKNOWN
Conditions: Sarcoma
Interventions: DRUG: sorafenib tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Personalized mRNA Vaccine Encoding Neoantigen in Subjects With Resected Digestive System Neoplasms
Status: RECRUITING
Conditions: Digestive System Neoplasms
Interventions: BIOLOGICAL: iNeo-Vac-R01 in combination with standard adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breaks From Sedentary Behavior With Dual Tasks in Elderly
Status: RECRUITING
Conditions: Aging
Interventions: OTHER: Break of sedentary behavior with dual task|OTHER: Break of sedentary behavior with walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Precision Prevention Strategy to Increase Uptake and Engagement in Lung Cancer Screening and Smoking Cessation Treatment
Status: ENROLLING_BY_INVITATION
Conditions: Smoking|Smoking Cessation|Tobacco Use Cessation
Interventions: BEHAVIORAL: Usual Care|BEHAVIORAL: RiskProfile-Clin|BEHAVIORAL: RiskProfile-Gen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Proof of Concept, Phase 2, Double-blind, Randomized Trial With d-Methadone Product Versus Placebo
Status: RECRUITING
Conditions: Restless Legs Syndrome
Interventions: DRUG: D-methadone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pemetrexed+Platinum Chemotherapy With or Without Pembrolizumab (MK-3475) in Participants With First Line Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-3475-189/KEYNOTE-189)-Japan Extension Study
Status: COMPLETED
Conditions: Non-Small-Cell Lung Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab 200 mg|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Pemetrexed|DIETARY_SUPPLEMENT: Folic acid 350-1000 μg|DIETARY_SUPPLEMENT: Vitamin B12 1000 μg|DRUG: Dexamethasone 4 mg|DRUG: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Using Placental Pathology to Prevent Recurrent Adverse Pregnancy Outcomes: A Pilot Project
Status: RECRUITING
Conditions: Adverse Pregnancy Outcome
Interventions: DRUG: Lovenox 40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: T-DM1+Pertuzumab in Pre-OP Early-Stage HER2+ BRCA
Status: ACTIVE_NOT_RECRUITING
Conditions: HER-2 Positive Breast Cancer|Breast Cancer|Stage II Breast Cancer|Stage III Breast Cancer
Interventions: DRUG: T-DM1|DRUG: Pertuzumab|PROCEDURE: Excision of tumor/mastectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Airway Clearance Techniques on GOR in Infants
Status: COMPLETED
Conditions: Gastro-oesophageal Reflux
Interventions: OTHER: AAD|OTHER: BAAD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Magnetic Seizure Therapy (MST) to Electroconvulsive Therapy (ECT) for Depression in Older Adults
Status: COMPLETED
Conditions: Depression|Major Depressive Episode|Bipolar Disorder
Interventions: DEVICE: MagVenture MagPro MST|BIOLOGICAL: RUL ECT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Collabree: A Remote Intervention to Improve the Regularity of Medication Intake
Status: ENROLLING_BY_INVITATION
Conditions: Hypertension|Medication Adherence
Interventions: BEHAVIORAL: Collabree Mobile Phone Application Medication Adherence Booster|BEHAVIORAL: Collabree Mobile Phone Application Medication Adherence Booster (simplified version)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Faecal Microbiota Transplantation (FMT) on Eradication of Multidrug Resistant Organisms (MRO) in Intestinal Carriers
Status: RECRUITING
Conditions: Multidrug Resistant Organisms|Faecal Microbiota Transplantation
Interventions: OTHER: Faecal microbiota transplantation|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Flow Nasal Oxygen Therapy Undergoing Colonoscopy
Status: UNKNOWN
Conditions: Apnea|Hypoxia
Interventions: DEVICE: High Flow Nasal Cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Comparing the Efficacy and Safety of Nivolumab in Combination With Bacillus Calmette-Guerin (BCG) Versus BCG Alone in Participants With High-Risk Non-Muscle Invasive Bladder Cancer (HR NMIBC)
Status: TERMINATED
Conditions: Urinary Bladder Neoplasms
Interventions: DRUG: nivolumab|OTHER: Placebo|BIOLOGICAL: Bacillus Calmette-Guérin (BCG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Grapefruit or Grapefruit Juice on Anthropometry, Dietary Intakes, Appetite, and Metabolic Profile in Overweight and Obese Young and Middle-Aged Adults
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: diet (grapefruit or grapefruit juice)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of the Efficacy and Safety of a Single Administration of Olokizumab vs. Placebo in Addition to Standard Treatment in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection (COVID-19).
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: Olokizumab 64 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Patients With suspeCted Coronary Artery Disease by Coronary calciUm fiRst strATegy vErsus Usual Care Approach.
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: PET Stress Test|OTHER: Non-PET Medical Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study to Evaluate the Safety, Tolerability and the Effect of BMS-241027 on Cerebrospinal Fluid Biomarkers in Subjects With Mild Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: BMS-241027|DRUG: BMS-241027|DRUG: BMS-241027|DRUG: Placebo matching BMS-241027
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cost-effectiveness of the Single-implant Mandibular Overdenture Versus Mandibular Conventional Denture
Status: COMPLETED
Conditions: Mouth, Edentulous|Complete Edentulism
Interventions: PROCEDURE: Mandibular overdenture|OTHER: Mandibular complete denture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imatinib (QTI571) in Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: imatinib mesylate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study to Treat Subjects With Symptomatic Internal Hemorrhoids
Status: TERMINATED
Conditions: Internal Hemorrhoids
Interventions: DRUG: Iferanserin|DRUG: Placebo|DRUG: Iferanserin + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Remediation of Emotional Deficits in Multiple Sclerosis and Traumatic Brain Injury
Status: COMPLETED
Conditions: Multiple Sclerosis|Traumatic Brain Injury
Interventions: BEHAVIORAL: Emotional Processing Training|BEHAVIORAL: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Rosiglitazone on Myocardial Blood Flow Regulation in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Rosiglitazone|DRUG: Glyburide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is it Possible to Replace Fentanyl in Anesthesia for Minor Procedures?
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Ketamine|DRUG: Propofol|DRUG: Fentanyl|DRUG: Cisatracurium|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Randomized Controlled Trial Comparing Two Timing Regimens of Pico-salax for Colon Cleansing Prior to Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: Pico-Salax|DRUG: Split Dose Pico-Salax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: ReStore Thrombectomy Trial for Flow Restoration in Acute Ischemic Stroke Patients
Status: SUSPENDED
Conditions: Ischemic Stroke
Interventions: DEVICE: thrombectomy (ReStore or Merci)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study With Gefitinib in Combination With Olaparib (AZD2281) Versus Gefitinib Alone
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Gefitinib|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Web-Based Patient Education on Quality of Life of Patients With Colostomy and Ileostomy
Status: COMPLETED
Conditions: Web Based Patient Education|Quality of Life|Ostomy
Interventions: OTHER: Implementation of web-based patient education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Astaxanthin on the Patients With Alzheimer Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: To Evaluate the Possible Benefit of Astaxanthin on Alzheimer Disease
Interventions: DIETARY_SUPPLEMENT: Astaxanthin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pulse Flours on Blood Glucose, Satiety and Food Intake
Status: COMPLETED
Conditions: Blood Glucose|Eating|Appetite|Food
Interventions: OTHER: Food-1|OTHER: Food-2|OTHER: Food-3|OTHER: Food-4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Prospective/Retrospective,Randomized Controlled Clinical Study of Interferon Atomization in the 2019-nCoV Pneumonia
Status: UNKNOWN
Conditions: 2019-nCoV
Interventions: DRUG: Abidol hydrochloride|DRUG: Abidol Hydrochloride combined with Interferon atomization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Rifampicin and Probenecid On The Pharmacokinetic Profile Of Rongliflozin In Healthy Subjects
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Rongliflozin|DRUG: Rifampin|DRUG: Rongliflozin|DRUG: Probenecid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PEG-Interferon Alfa-2b in Treating Young Patients With Plexiform Neurofibroma
Status: COMPLETED
Conditions: Neoplasm of Uncertain Malignant Potential|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: PEG-interferon alfa-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of KRN23 in X-linked Hypophosphatemia
Status: COMPLETED
Conditions: X-linked Hypophosphatemia
Interventions: DRUG: Placebo|DRUG: KRN23
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SAALT: Subtracting Salt and Adding Losartan Trial (0954A-335)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: losartan potassium (+ hydrochlorothiazide [HCTZ] + calcium channel blocker [CCB])|BEHAVIORAL: Low Salt Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medico-economic Impact Evaluation in Telemedecine Follow-up in Complement of a Mobile Team in Patients With Neurological Disabilities (HANDI@CCESS)
Status: COMPLETED
Conditions: Severe Neurological Disabilities
Interventions: OTHER: Telemedecine follow-up after an intervention at home of the mobile team|OTHER: Mobile team follow-up after an intervention at home of the mobile team
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Pharmacokinetics of Oral Controlled-ileocolonic-release Nicotinamide (CICR-NAM)
Status: COMPLETED
Conditions: Safety Issues|Pharmacokinetic
Interventions: DRUG: controlled-ileocolonic-release nicotinamide (SAD/MAD/MD)|DRUG: Immediate-release nicotinamide (SAD)|DRUG: Placebo controlled-ileocolonic-release nicotinamide (SAD/MAD)|DRUG: Placebo Immediate-release nicotinamide (SAD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Secondary Primary Tumor Prevention With EGFR, OSI-774, and Cyclooxygenase-2
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: Erlotinib|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Attentional Focus and Prefrontal Cortical Activation in Older Adults and Patients With Parkinson's Disease (PD)
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: Functional Near-Infrared Spectroscopy (fNIRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial Comparing Surgeon-administered TAP Block With Placebo After Midline Laparotomy in Gynecologic Oncology
Status: UNKNOWN
Conditions: Genital Neoplasm Malignant Female|Surgical Procedure, Unspecified
Interventions: PROCEDURE: Surgeon-administered transversus abdominis plane (TAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Uproleselan, Cladribine, and Low Dose Cytarabine for the Treatment of Patients With Treated Secondary Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Secondary Acute Myeloid Leukemia
Interventions: DRUG: Cladribine|DRUG: Cytarabine|DRUG: Uproleselan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study of MEDI7734 in Type I Interferon-Mediated Autoimmune Diseases
Status: COMPLETED
Conditions: Dermatomyositis, Polymyositis, Sjogren's, SLE, SSc
Interventions: BIOLOGICAL: MEDI7734|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Retreatment of 177Lu-DOTATATE PRRT Versus Everolimus in Patients With Metastatic Unresectable Midgut Neuroendocrine Tumors, NET RETREAT Trial
Status: RECRUITING
Conditions: Metastatic Midgut Neuroendocrine Tumor|Metastatic Midgut Neuroendocrine Tumor G1|Metastatic Midgut Neuroendocrine Tumor G2|Unresectable Midgut Neuroendocrine Tumor
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Everolimus|DRUG: Lutetium Lu 177 Dotatate|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radius Fracture Anesthesia and Rehabilitation (RADAR)
Status: COMPLETED
Conditions: Radial Fracture
Interventions: PROCEDURE: Long acting Supraclivicular block vs Short acting Supraclavicular block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Memantine (10mg BID) for the Frontal and Temporal Subtypes of Frontotemporal Dementia
Status: COMPLETED
Conditions: Frontal Lobe Dementia|Frontotemporal Lobe Dementia|Semantic Dementia
Interventions: DRUG: memantine|DRUG: Placebo pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Morphine Added to Bupivacaine in Transversus Abdominis Plane Block for Inguinal Hernia Repair
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: COMBINATION_PRODUCT: bupivacaine and morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving the Treatment of Acute Relapses in Multiple Sclerosis Through Intranasal Methylprednisolone Administration
Status: ENROLLING_BY_INVITATION
Conditions: Methylprednisolone|Intranasal Administration|Patients With an Active Multiple Sclerosis Relapse
Interventions: OTHER: IV Methylprednisolone administration|DRUG: Nasal Methylprednisolone (MT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Before and After Surgery in Treating Patients With Localized Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Acinar Cell Adenocarcinoma of the Pancreas|Duct Cell Adenocarcinoma of the Pancreas|Stage I Pancreatic Cancer|Stage IIA Pancreatic Cancer|Stage IIB Pancreatic Cancer
Interventions: DRUG: oxaliplatin|DRUG: leucovorin calcium|DRUG: irinotecan hydrochloride|DRUG: fluorouracil|PROCEDURE: therapeutic conventional surgery|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Stereotactic Body Radiotherapy for Treatment of Primary Renal Cell Carcinoma Tumors
Status: TERMINATED
Conditions: Primary Tumor|Renal Cell Carcinoma
Interventions: RADIATION: Stereotactic Body Radiotherapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of RP-3500 in Combination With Standard Radiation Therapy in People With Solid Tumor Cancer
Status: RECRUITING
Conditions: Solid Tumor|Metastatic Cancer
Interventions: DRUG: RP-3500|RADIATION: External Beam Radiotherapy (EBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fosaprepitant , Tropisetron and Olanzapine for the Prevention of Nausea and Vomiting in Patients With Breast Cancer
Status: COMPLETED
Conditions: Chemotherapy-induced Nausea and Vomiting
Interventions: DRUG: Fosaprepitant , Tropisetron and Olanzapine|DRUG: Fosaprepitant , Tropisetron, Dexamethasone and Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methylnaltrexone in Patients With Opioid-Induced Bowel Dysfunction
Status: COMPLETED
Conditions: Bowel Dysfunction
Interventions: DRUG: SC MNTX|DRUG: SC MNTX|DRUG: SC MNTX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perflutren Protein-Type A Microspheres and Contrast-Enhanced Ultrasound in Improving Response to Radioembolization Therapy in Patients With Liver Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: Yttrium-90 Microsphere Radioembolization|DRUG: Perflutren Protein-Type A Microspheres|PROCEDURE: Dynamic Contrast-Enhanced Ultrasound Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Non-exposure Simple Suturing EFTR With Sentinel Lymph Node Navigation for EGC (Senorita3-pilot)
Status: UNKNOWN
Conditions: Early Gastric Cancer
Interventions: PROCEDURE: NESS-EFTR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measurement of Anti-Androgen Response Using Fluorine-18 Fluorocholine PET/CT in Androgen-Insensitive Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: IV administration of fluorine-18 fluorocholine followed by PET/CT imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Deprescribing Inappropriate Proton Pump Inhibitors
Status: NOT_YET_RECRUITING
Conditions: Inappropriate Prescribing|Reflux Disease|Proton Pump Inhibitors
Interventions: OTHER: Proton Pump Inhibitor deprescribing tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Clinical Pharmacology of GDC-0068 in Combination With Docetaxel, Fluoropyrimidine Plus Oxaliplatin, Paclitaxel, or Enzalutamide in Participants With Advanced Solid Tumors
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: 5-FU|DRUG: Docetaxel|DRUG: Enzalutamide|DRUG: Ipatasertib|DRUG: Leucovorin|DRUG: Oxaliplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-dose Fostemsavir Extended Release Relative Bioavailability Study
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Fostemsavir 600 mg|DRUG: Fostemsavir 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digital Applications to Monitor Novel Coronavirus Disease and Response in Colombia - Syndromic and Vaccination Surveillance
Status: COMPLETED
Conditions: Vaccination Refusal|COVID-19
Interventions: BEHAVIORAL: Factual messages|BEHAVIORAL: Narrative message|BEHAVIORAL: Mixed message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Influence of Probiotics on Vancomycin-Resistant Enterococcus
Status: TERMINATED
Conditions: GI Colonization of Vancomycin-resistant Enterococcus
Interventions: DIETARY_SUPPLEMENT: probiotics|DIETARY_SUPPLEMENT: yogurt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Trial of a Botanical Drug Containing East Indian Sandalwood Oil (EISO) for the Treatment of External Genital Warts
Status: TERMINATED
Conditions: Condylomata Acuminata
Interventions: DRUG: East Indian Sandalwood Oil Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Effects of Aspirin & Metformin on Colonic Epithelium
Status: UNKNOWN
Conditions: Colorectal Cancer|Colorectal Neoplasms|Colorectal Adenoma
Interventions: DRUG: Aspirin tablet|DRUG: Metformin|DRUG: Aspirin and Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PeriOperative ISchemic Evaluation-2 Trial
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DRUG: Active Clonidine|DRUG: Placebo Clonidine|DRUG: Active ASA|DRUG: Placebo ASA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Albuterol Administered by the Halix™ Dry Powder Inhaler in Subjects With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Halix albuterol 90 mcg|DRUG: albuterol HFA MDI 90 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Bupropion on the Effects of MDMA
Status: COMPLETED
Conditions: Healthy|Substance-related Disorders
Interventions: DRUG: MDMA|DRUG: Bupropion|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Wound And Symptom Tracking After Colorectal Surgery Using How2trak
Status: UNKNOWN
Conditions: Surgical Site Infection|Mobile Applications|Surgery--Complications|Colorectal Surgery
Interventions: DEVICE: How2Trak mobile application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Magnetic Resonance Imaging in Detecting Cancer Progression in Patients With Early Stage Prostate Cancer Undergoing Active Surveillance
Status: WITHDRAWN
Conditions: Prostate Cancer
Interventions: OTHER: active surveillance|OTHER: imaging biomarker analysis|PROCEDURE: biopsy|PROCEDURE: dynamic contrast-enhanced magnetic resonance imaging|PROCEDURE: magnetic resonance imaging|PROCEDURE: magnetic resonance spectroscopic imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ball Vs Locator Attachment in Overdenture Retained by Single Mandibular Implant
Status: UNKNOWN
Conditions: Edentulous Jaw
Interventions: DEVICE: mandibular overdenture retained with single midline implant using locator attachment|DEVICE: mandibular overdenture retained with single midline implant using ball attachment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial of Neuroprotection With ACTH in Acute Optic Neuritis
Status: TERMINATED
Conditions: Multiple Sclerosis
Interventions: DRUG: ACTHAR Gel (ACTH)|DRUG: IV methylprednisolone (steroids)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Substance Misuse To Psychiatric Disorders for Cannabis
Status: COMPLETED
Conditions: Cannabis Use Disorder|Depressive State|Anxiety State|Depression|Anxiety Disorders|Pharmacotherapy
Interventions: DRUG: Vortioxetine|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Propionic Acid on Regulatory T Cell Function in Healthy Adults ( Pro-Health)
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Sodium propionate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Blood Pressure Effects on Cognition and Brain Blood Flow in PD
Status: RECRUITING
Conditions: Parkinson Disease|Orthostatic Hypotension|Dysautonomia
Interventions: DIAGNOSTIC_TEST: Tilt table (upright position)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase 1/2a Safety and Efficacy of ALY688 Ophthalmic Solution in Subjects With Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: ALY688 0.1%|DRUG: ALY688 0.4%|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of BNP (Brain Natriuretic Peptides) on Endothelial Dysfunction Induced by Coronary Angioplasty
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: Nesiritide,
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Phase I Study of HS-10509 in Chinese Adult Subjects
Status: NOT_YET_RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: HS-10509|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Phase II Study for Adjuvant Hypofractionated Intensity-modulated Proton Radiotherapy for Post Operative Breast Cancer With Implantation Reconstruction
Status: RECRUITING
Conditions: Breast Cancer
Interventions: RADIATION: adjuvant hypofractionated intensity-modulated proton radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability Study of V501 in Japanese Males (V501-122)
Status: COMPLETED
Conditions: Anogenital Human Papilloma Virus Infection|Condyloma Acuminata
Interventions: BIOLOGICAL: V501|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of rTMS Compared to SSRI as Early Treatment of Depression (Early-TMS)
Status: NOT_YET_RECRUITING
Conditions: Major Depressive Disorder
Interventions: DEVICE: bilateral theta burst stimulation|DRUG: SSRI treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 24-week Off-drug Extension Study in Sarcopenic Elderly Who Completed Treatment in the 6-month Core Study
Status: COMPLETED
Conditions: Sarcopenia
Interventions: DRUG: bimagrumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgery for Esotropia Under Topical Anesthesia
Status: UNKNOWN
Conditions: Esotropia
Interventions: PROCEDURE: Topical strabismus surgery|PROCEDURE: Sub-Tenon's strabismus surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repeated Measures Trial of Temporary Automated Manual Ventilation Versus Noninvasive Oxygenation or Conventional Vent
Status: WITHDRAWN
Conditions: Respiratory Failure
Interventions: DEVICE: Mechanical ventilation with the automated BVM compressor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Two-step Anesthesia in Posterior Vitrectomy
Status: UNKNOWN
Conditions: Anesthesia, Local
Interventions: PROCEDURE: retrobulbar anesthesia|PROCEDURE: peribulbar anesthesia|PROCEDURE: two step anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Defining the Immune Response to Nasopharyngeal Colonisation by the Commensal Neisseria Lactamica
Status: COMPLETED
Conditions: Meningitis, Bacterial
Interventions: BIOLOGICAL: N. lactamica|OTHER: PBS only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Azadirachta Indica (Neem) Extract as an Adjunct to Non-Surgical Periodontal Management
Status: COMPLETED
Conditions: Periodontitis
Interventions: DRUG: Azadirachta Indica|PROCEDURE: Non Surgical Periodontal Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaginal Dinoprostone Prior to Diagnostic Office Hysteroscopy in Primarily Infertile Patients
Status: UNKNOWN
Conditions: Hysteroscopy
Interventions: DRUG: vaginal dinoprostone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nipple-Areola Complex (NAC) Irradiation After Nipple-Sparing Mastectomy and Reconstruction
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Ductal Carcinoma
Interventions: PROCEDURE: Nipple-Sparing Mastectomy|PROCEDURE: Breast Reconstruction|PROCEDURE: Axillary Surgery|RADIATION: Prophylactic Nipple-Areolar Complex RT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Trovax® Plus Docetaxel Versus Docetaxel Alone in Patients With Progressive Hormone Refractory Prostate Cancer
Status: TERMINATED
Conditions: Prostatic Neoplasms
Interventions: BIOLOGICAL: MVA 5T4|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Osteoarthritis|Hip Osteoarthritis
Interventions: DRUG: Low-Dose Bupivacaine|DRUG: Mepivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Two Different Cataract Surgical Procedures to Prevent Posterior Capsule Opacification
Status: UNKNOWN
Conditions: Cataract|Posterior Capsule Opacification
Interventions: PROCEDURE: Anterior lens capsule was reserved
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Fluconazole to Treat Coccidioidomycosis Pneumonia (Valley Fever)
Status: TERMINATED
Conditions: Coccidioidomycosis
Interventions: DRUG: Fluconazole|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nimotuzumab in Combination With Chemoradiation for Local Advanced Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Squamous Cell Carcinoma
Interventions: DRUG: Nimotuzumab|DRUG: Placebo|DRUG: cisplatin|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgery and Heated Intraperitoneal Chemotherapy for Adrenocortical Carcinoma
Status: RECRUITING
Conditions: Adrenocortical Carcinoma|Peritoneal Carcinomatosis
Interventions: DRUG: Cisplatin|DRUG: Sodium thiosulfate|PROCEDURE: Cytoreductive surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploration of the Activity of DNA Located Outside of Cellular Nucleus to Amplify Inflammation in Inflammatory Bowel Disease in Children Through Biological Pathway Cyclic GMP-AMP Synthase (cGAS) - Stimulator of Interferon Genes (STING)
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases|Crohn Disease|Ulcerative Colitis
Interventions: BIOLOGICAL: Blood and fecal samples|PROCEDURE: Coolonic biopsies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Bonviva (Ibandronate) in Women With Post-Menopausal Osteoporosis Who Have Received Previous Bonviva Treatment
Status: COMPLETED
Conditions: Post-Menopausal Osteoporosis
Interventions: DRUG: ibandronate [Bonviva/Boniva]|DRUG: ibandronate [Bonviva/Boniva]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pedialyte or Gatorade for Viral Gastroenteritis in Adults: a Randomized, Controlled Trial
Status: COMPLETED
Conditions: Gastroenteritis
Interventions: DRUG: Gatorade, Pedialyte and New Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Follow up Study 5-6 Years After ILIT With 2 Concomitant Allergens, Birch and Grass
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: ALK Alutard 5-grasses and birch|DRUG: ALK Diluent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Drug Combinations Against Schistosomiasis
Status: COMPLETED
Conditions: Parasitic Diseases
Interventions: DRUG: albendazole + praziquantel|DRUG: mebendazole + praziquantel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Evaluation of First-dollar Coverage for Post-MI Secondary Preventive Therapies
Status: COMPLETED
Conditions: Myocardial Infarction|Coronary Artery Disease
Interventions: OTHER: Full drug coverage|OTHER: Usual coverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Opioid Use Disorder in Pregnancy in Long-Term Maternal/Infant Outcomes
Status: RECRUITING
Conditions: Opioid-use Disorder|Opioid Use, Unspecified|Buprenorphine Dependence
Interventions: DRUG: Subutex / Buprenorphine|DIAGNOSTIC_TEST: Fetal & Neonatal MRI|DIAGNOSTIC_TEST: DNA/Genetic/Pharmacokenetic Blood Draws
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Non-inferiority Clinic of Kollagenase® Compared Iruxol® in Treatment of Cutaneous Ulcers
Status: SUSPENDED
Conditions: Ulcers
Interventions: BIOLOGICAL: collagenase (IRUXOL)|BIOLOGICAL: collagenase (Kollagenase)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bariatric Surgery for the Reduction of cArdioVascular Events Randomized Controlled Trial
Status: RECRUITING
Conditions: Cardiovascular Complication|Bariatric Surgery Candidate
Interventions: PROCEDURE: Bariatric Surgery|BEHAVIORAL: Medical Weight Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective, Multi-Center, Random. Study of CoStar Paclitaxel-Eluting Coronary Stent(Direct Stenting vs. Pre-Dilatation)
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: DEVICE: CoStar Paclitaxel-eluting coronary stent system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fasting Study of Valacyclovir Hydrochloride Tablets 1000 mg and Valtrex® Tablets 1000 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Valacyclovir Hydrochloride Tablets 1000 mg|DRUG: Valtrex® Tablets 1000 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Working to Implement and Sustain Digital Outcome Measures
Status: COMPLETED
Conditions: Implementation|Behavioral Symptoms
Interventions: BEHAVIORAL: Leadership for Organization Change and Implementation (LOCI)|BEHAVIORAL: Training and Technical Assistance Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Testing Effect and Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Episodic Memory Deficits
Interventions: BEHAVIORAL: Retrieval practice effect using word pairs and cued recall tests with feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bortezomib and Cetuximab in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Breast Cancer|Colorectal Cancer|Head and Neck Cancer|Kidney Cancer|Lung Cancer|Pancreatic Cancer|Sarcoma|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: cetuximab|DRUG: bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of HEC53856 in Patients With Subjects With End-Stage Renal Disease Receiving Dialysis.
Status: UNKNOWN
Conditions: Hemodialysis|Peritoneal Dialysis
Interventions: DRUG: HEC53856
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PIB Versus CI Through a Popliteal Sciatic Nerve Catheter for Analgesia Following Major Ankle Surgery
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: CI 0.2% ropivacaine|DRUG: PIB 0.2% ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Lipoic Acid and Eicosapentaenoic Acid (EPA) in Human Obesity
Status: COMPLETED
Conditions: Obesity|Body Fat|Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: Double blind dietary intervention with EPA and lipoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Treatment of Steroids for Capsular Contracture in Patients With Reconstructed/Augmented Breast
Status: UNKNOWN
Conditions: Capsular Contracture, Implant
Interventions: DRUG: Dexamethasone|DEVICE: US
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digital Holographic Microscopy: Evaluation of Histological Disease Activity in Patients With Ulcerative Colitis
Status: UNKNOWN
Conditions: Colitis, Ulcerative|Inflammatory Bowel Diseases
Interventions: DEVICE: digital holographic microscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Preoperative Chemoradiotherapy and Transanal Endoscopic Microsurgery Versus Ttransanal Endoscopic Microsurgery in T1 N0, M0 Rectal Cancer (TAUTEM-T1 Study)
Status: NOT_YET_RECRUITING
Conditions: Rectal Cancer Stage I
Interventions: DRUG: Capecitabine (Xeloda)|RADIATION: 50.4 Gy|PROCEDURE: Transanal Endoscopic Microsurgery (TEM)|PROCEDURE: Transanal Endoscopic Microsurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Exercise Treatments for Older Veterans With Motoric Cognitive Risk Syndrome
Status: NOT_YET_RECRUITING
Conditions: Motoric Cognitive Risk Syndrome
Interventions: BEHAVIORAL: Functional Power Training (FPT)|BEHAVIORAL: Music-Based Digital Therapy (MBDT)|BEHAVIORAL: FPT + MBDT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Augmenting Cerebral Blood Flow to Treat Established Multiple Sclerosis
Status: TERMINATED
Conditions: Multiple Sclerosis
Interventions: DRUG: Acetazolamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY2189265 Compared to Sitagliptin in Participants With Type 2 Diabetes Mellitus on Metformin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: LY2189265|DRUG: Sitagliptin|DRUG: Placebo solution|DRUG: Placebo tablet|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT