pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Myocet, Docetaxel & Trastuzumab as 1st Line Treatment of Patients With HER-2/Neu Positive Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Liposomal Doxorubicin (Myocet), Docetaxel and Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Re-inforcement Learning to Automatically Adapt a Remote Therapy Intervention (RTI) for Reducing Adolescent Violence Involvement
Status: RECRUITING
Conditions: Violence|Substance Use|Criminal Behavior|Violence in Adolescence
Interventions: BEHAVIORAL: Remote Therapy Intervention (RTI)|BEHAVIORAL: Artificial Intelligence Remote Therapy Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Pain Suppressive Effect of Alternative Spinal Cord Stimulation Frequencies
Status: COMPLETED
Conditions: Failed Back Surgery Syndrome|Neuropathic Pain
Interventions: DEVICE: Spinal Cord Stimulation|DEVICE: Group 1|DEVICE: Group 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Serum and Urinary Biomarkers and Radiation Cystitis in Patients Treated With Radiotherapy for Localized Prostate Cancer
Status: RECRUITING
Conditions: Radiation Cystitis|Prostate Cancer|Radiotherapy Side Effect
Interventions: BIOLOGICAL: Biological sample collection|OTHER: Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: FcRn Antagonists (Efgartigimod) for Acute NMOSD Attack
Status: NOT_YET_RECRUITING
Conditions: Neuromyelitis Optica|Neuromyelitis Optica Spectrum Disorder|NMO Spectrum Disorder
Interventions: DRUG: Efgartigimod Alfa Injection|DRUG: High-dose intravenous methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Proof-of-concept Trial to Evaluate the Safety and Efficacy of UB-421 Plus Chidamide in Changing HIV Reservoirs
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: BIOLOGICAL: UB-421|DRUG: chidamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Consumption Safety and Effect of Mulberry Leaves and Vietnamese Coriander Based Instant Polyherbal Porridge on Working Memory and Bone Formation Markers
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: MP 50 mg/day|DIETARY_SUPPLEMENT: MP 1500 mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Early Experience of a New Implant System for Bone Conduction Hearing in the Pediatric Population
Status: COMPLETED
Conditions: Unilateral Mixed Conductive and Sensorineural Hearing Loss (Diagnosis)|Sensorineural Hearing Loss, Unilateral With Normal Hearing on the Contralateral Side
Interventions: DEVICE: Osseointegrated Steady State Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Planning a Multi-Level Intervention to Reduce Substance Use Stigma in HIV Prevention and Care
Status: COMPLETED
Conditions: Social Stigma|Substance Use Disorders|HIV Infections|Physician-Patient Relations
Interventions: BEHAVIORAL: Substance use stigma training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Improving Asthma Care by Partnering With School Nurses to Bring Asthma Care Into the Inner-City Schools
Status: COMPLETED
Conditions: Asthma
Interventions: DEVICE: Sensor cap system for inhalers|OTHER: App for SmartPhone|BEHAVIORAL: Motivational interviews|OTHER: Telehealth clinic visits
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of a Commercially Available Injectable Hyaluronic Acid Dental Filler for Periodontal Pockets
Status: UNKNOWN
Conditions: Chronic Periodontitis
Interventions: DEVICE: PERIOSYAL FILL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Cerebral Perfusion During the Period of Deep Hypothermia at 18°C in Patient Undergoing Pulmonary Endarterectomy Surgery.
Status: RECRUITING
Conditions: Hypothermia|Cerebral Perfusion|Transcranial Doppler Ultrasound|Pulmonary Hypertension
Interventions: PROCEDURE: Bilateral trans-cranial Doppler ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: pRospective Evaluation of Clinical Outcomes in Patients With metAsTatIс melanOma Treated With dabrafeNib and trAmetinib in reaL practicE
Status: RECRUITING
Conditions: Melanoma Stage III|Melanoma Stage IV|Melanoma
Interventions: DRUG: Dabrafenib|DRUG: Trametinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Longitudinal Effect of Electroconvulsive Therapy on Schizophrenia and Bipolar Disorder: a MRI Study
Status: UNKNOWN
Conditions: Schizophrenia, Bipolar Disorder
Interventions: DEVICE: ECT treatment|DRUG: Drug treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparing Artificial Intelligence for Assisted Diagnosis of Diabetic Retinopathy
Status: NOT_YET_RECRUITING
Conditions: Diabetic Retinopathy|Diabetic Macular Edema
Interventions: DIAGNOSTIC_TEST: fundus photography|DIAGNOSTIC_TEST: optical coherence tomography|DIAGNOSTIC_TEST: fundus fluorescence angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multicenter Randomized Trial of 68Ga-PSMA-11 PET/CT Based SRT After Radical Prostatectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Prostate Carcinoma
Interventions: OTHER: Best Practice|PROCEDURE: Computed Tomography|RADIATION: Gallium Ga 68-labeled PSMA-11|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Routine Anterior Crural Repair in De-Novo Gastroesophageal Reflux After Laparoscopic Sleeve Gastrectomy
Status: RECRUITING
Conditions: Obesity|Gastro Esophageal Reflux Disease
Interventions: PROCEDURE: Standard Sleeve Gastrectomy plus Anterior Crural Repair|PROCEDURE: Standard sleeve gastrectomy (SSG, the control group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment With Lactobacillus Rhamnosus and Lactobacillus Acidophilus for Patients With Active Colonic Crohn's Disease.
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: BEHAVIORAL: Administration of probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Immune Checkpoint Inhibitors for Organ Preservation in Non-metastatic dMMR/MSI-H Gastric or Colon Cancers
Status: RECRUITING
Conditions: Gastric Cancer|Colon Cancer|MSI-H|DMMR Cancer
Interventions: DRUG: PD1/PDL1 antibody monotherapy, up to 24 weeks|COMBINATION_PRODUCT: Intensive immunotherapy plus anti-VEGF treatment, up to 24 weeks|PROCEDURE: Radical surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Effectiveness, Safety, and Performance of the Evoke Closed-Loop SCS System to Treat Patients With Chronic Pain of the Trunk and/or Limbs
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Pain
Interventions: DEVICE: Evoke Spinal Cord Stimulation (SCS) System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bupropion for the Prevention of Postpartum Smoking Relapse
Status: RECRUITING
Conditions: Postpartum Smoking Relapse
Interventions: DRUG: Bupropion Extended Release Oral Tablet|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Innovative Imaging of the Conjunctiva, Cornea, and Ocular Adnexa
Status: COMPLETED
Conditions: Corneal Disease|Blepharitis|Lacrimal Apparatus Diseases
Interventions: DEVICE: Handheld IVCM Vivascope 3000 (Caliber/Mavig) anesthesic eyedrop : oxybuprocaïne Thea 1,6 mg/0,4 ml|DEVICE: Multifluorescence IVCM vivascope 1500 ML (Caliber/Mavig)|PROCEDURE: microangiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Left Ventricular Volume and Ejection Fraction: Validation of Real Time 3 Dimensional Transesophageal Echocardiography
Status: WITHDRAWN
Conditions: 3D Transesophageal and Transthoracic Echocardiogram
Interventions: PROCEDURE: transesophageal echocardiography (TEE)|PROCEDURE: thermodilution|PROCEDURE: transthoracic echocardiography (TTE)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MRD Guided Sonrotoclax and Zanubrutinib in Newly Diagnosed CLL/SLL
Status: NOT_YET_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Sonrotoclax|DRUG: Zanubrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Effects of Limosilactobacillus Reuteri Probiotics as an Adjunct to the Treatment of Periodontitis
Status: RECRUITING
Conditions: Chronic Periodontitis, Generalized
Interventions: OTHER: Probiotics|OTHER: Negative control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Relief for OsteoArthritis Through Combined Treatment (PROACT)
Status: RECRUITING
Conditions: Osteoarthritis of Knee
Interventions: BEHAVIORAL: Focused Breathing and Attention Training (BAT)|BEHAVIORAL: Standard Breathing and Attention Training (BAT)|DEVICE: Transcranial Direct Current Stimulation (tDCS)|DEVICE: Sham Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy, Safety and Tolerability of PXT002331 (Foliglurax) in Reducing Motor Complications of Levodopa Therapy in Parkinson Disease's Patients
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Placebo oral capsule|DRUG: PXT002331 - dose 1|DRUG: PXT002331 - dose 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of a Recombinant Fusion Protein Linking Coagulation Factor IX With Albumin (rIX-FP) in Patients With Hemophilia B
Status: COMPLETED
Conditions: Hemophilia B
Interventions: BIOLOGICAL: rIX-FP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Portal Vein Embolization and Liver Venous Deprivation
Status: RECRUITING
Conditions: Liver Venous Deprivation
Interventions: PROCEDURE: PVE|PROCEDURE: LVD
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy and Safety of SCT510 in the Treatment of Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-squamous Cell Non-small Cell Lung Cancer
Interventions: DRUG: SCT510|DRUG: Bevacizumab|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Radiation and Tumor Treating Fields for Locally Advanced Pancreas Cancer
Status: RECRUITING
Conditions: Pancreas Cancer|Locally Advanced|Locally Advanced Pancreatic Adenocarcinoma
Interventions: RADIATION: Stereotactic Ablative Body Radiation (SABR)|DEVICE: Tumor Treating Fields (TTF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing and Promoting Resilience in Patients With Adult Congenital Heart Disease
Status: COMPLETED
Conditions: Congenital Heart Disease
Interventions: BEHAVIORAL: Promoting Resilience in Stress Management (PRISM)|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Intra-articular Allocetra in Knee Osteoarthritis
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Allocetra|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-inferiority Study of GSK Biologicals' Influenza Vaccine GSK576389A Using Different Formulations
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Thiomersal-free FluAS25 adjuvanted vaccine (GSK576389A)|BIOLOGICAL: Thiomersal reduced FluAS25 adjuvanted vaccine (GSK576389A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Resistant Starch and Non-starch Polysaccharide (Dietary Fibre) Intake and the Colonic Microbiome in Older People
Status: WITHDRAWN
Conditions: Aging
Interventions: DIETARY_SUPPLEMENT: Resistant starch|DIETARY_SUPPLEMENT: Dietary fibre (arabinogalactan, gum guar, pectin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Eating Phenotypes for Childhood Obesity in the Context of Familial Obesity Risk
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: % COMPX (low ED vs. high ED preload)|BEHAVIORAL: EAH (low ED vs. high ED snacks)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Development and Testing of an Electronic Behavioral Health Record Specific to the Wraparound Care Coordination Process
Status: UNKNOWN
Conditions: Serious Emotional Disturbance of Youth
Interventions: BEHAVIORAL: Wraparound Team Monitoring System electronic health record|BEHAVIORAL: Education about fidelity maintenance and monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Comparison of the Success Rate of the Endotracheal Intubation Between the Stylet and the Frova With Acute Angled Videolaryngoscope
Status: RECRUITING
Conditions: Anesthesia, General
Interventions: DEVICE: Frova|DEVICE: Stylet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of MEDI4736 Monotherapy and in Combination With Tremelimumab Versus Standard of Care Therapy in Patients With Head and Neck Cancer
Status: COMPLETED
Conditions: Recurrent or Metastatic PD-L1-positive or -Negative Squamous Cell Carcinoma of the Head and Neck SCCHN
Interventions: DRUG: MEDI4736|DRUG: MEDI4736 + Tremelimumab|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation
Status: RECRUITING
Conditions: Infections|Infected Wound|Nonunion of Fracture|Injury Leg|Amputation|Internal Fixation; Complications, Infection or Inflammation|Fracture|Lower Extremity Fracture|Antibiotic Side Effect
Interventions: DRUG: Standard of Care PO (oral) antibiotics|DRUG: Standard of Care Intravenous (IV) antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotic and Antibiotic Therapies in Women With Unexplained Infertility
Status: WITHDRAWN
Conditions: Unexplained Infertility|Endometriosis
Interventions: OTHER: SH-DS01 + Antibiotic Placebo|DRUG: SH-DS01 + Metronidazole|OTHER: Probiotic Placebo + Antibiotic Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remission Evaluation of Metabolic Interventions in Type 2 Diabetes (REMIT Pilot Trial)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: insulin glargine|DRUG: metformin|DRUG: acarbose|BEHAVIORAL: lifestyle therapy|DRUG: insulin glargine|DRUG: metformin|DRUG: acarbose|BEHAVIORAL: lifestyle therapy|OTHER: Standard glycemic care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of High Protein and Low Carbohydrate Smoothie Drinks in Type-2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DIETARY_SUPPLEMENT: smoothie with regular formulas (SM)|DIETARY_SUPPLEMENT: smoothie with low carbohydrate formulas (SMLS)|DIETARY_SUPPLEMENT: conventional diabetic enteral drinks (Glucerna)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Zolpidem for Sleep in Children With Autism
Status: RECRUITING
Conditions: Autism|Autism Spectrum Disorder
Interventions: DRUG: Zolpidem|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Impact of Inorganic Nitrate-rich Beetroot Juice on Microvascular Blood Flow and Cognitive Function
Status: NOT_YET_RECRUITING
Conditions: Post Menopausal
Interventions: DIETARY_SUPPLEMENT: Concentrated beetroot juice|DIETARY_SUPPLEMENT: Nitrate depleted beetroot juice + potassium nitrate (KNO3)|DIETARY_SUPPLEMENT: Nitrate depleted beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
Status: RECRUITING
Conditions: Cancer, Metastatic|Cancer|Cancer of Pancreas|Cancer of Liver|Cancer of Stomach|Cancer Liver|Cancer of Rectum|Cancer of Kidney|Cancer of Esophagus|Cancer of Cervix|Cancer of Colon|Cancer of Larynx|Cancer, Lung|Cancer, Breast|Cancer, Advanced|Cancer Prostate|Cancer of Neck|Cancer of Skin|Neuroendocrine Tumors|Carcinoma|Mismatch Repair Deficiency|BRCA Gene Rearrangement|Non Hodgkin Lymphoma|Leukemia|Non Small Cell Lung Cancer|Cholangiocarcinoma|Glioblastoma|Central Nervous System Tumor|Melanoma|Urothelial Carcinoma|Bladder Cancer|Ovarian Cancer|Endometrial Cancer|Testicular Cancer|Breast Cancer|COVID|Myelofibrosis|Myeloproliferative Neoplasm|Myeloproliferative Disorders|Follicular Lymphoma|Mantle Cell Lymphoma|Marginal Zone Lymphoma|Myelodysplastic Syndromes
Interventions: OTHER: Clinical Trial Matching
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Non-Pharmacological Treatments for Insomnia in Chronic Traumatic Brain Injury
Status: COMPLETED
Conditions: Insomnia|Traumatic Brain Injury
Interventions: BEHAVIORAL: CBT-I|BEHAVIORAL: ABT-I
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Prehabilitation on Surgical Outcomes of Abdominally-based Plastic Surgery Procedures
Status: RECRUITING
Conditions: Ventral Hernia|Panniculus|Abdominoplasty|Flap Reconstruction
Interventions: BEHAVIORAL: Prehabilitation Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: G7 BiSpherical Acetabular Shell PMCF Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Rheumatoid Arthritis|Osteoarthritis|Noninflammatory Degenerative Joint Disease|Avascular Necrosis|Correction of Functional Deformity|Non-Union Fracture|Femoral Neck Fractures|Trochanteric Fractures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immune Reconstitution in HIV Disease (IREHIV)
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: vitamin D (cholecalciferol) and PBA (sodium phenylbutyrate)|DRUG: Placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Closed-loop tACS Modulation for the Core Clinical Features of Drug Addiction
Status: NOT_YET_RECRUITING
Conditions: Amphetamine Use Disorders
Interventions: DEVICE: Closed-loop tACS stimulation based on addiction-induced states
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate Efficacy and Safety of ALLO-ASC-DFU in Patients With Diabetic Foot Ulcers.
Status: COMPLETED
Conditions: Diabetic Foot Ulcer
Interventions: BIOLOGICAL: ALLO-ASC-DFU|PROCEDURE: Vehicle sheet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preventive Effect of Perinatal Oral Probiotic Supplementation (POPS) on Neonatal Jaundice
Status: RECRUITING
Conditions: Neonatal Jaundice|Microtia|Pregnancy Related|Hyperbilirubinemia, Neonatal
Interventions: DIETARY_SUPPLEMENT: Vivomixx®|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Normal and Abnormal ERP During ToM and Emotional Conflicts in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Theory of mind without visual cues|BEHAVIORAL: Theory of mind without visual cues
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparing the Effect of Adding a Remote Self-reporting Tool for Distress and Fit-for-purpose Mental Health & Addictions Service to Usual Case Management on Dropout Rates in a Vocational Training Program
Status: NOT_YET_RECRUITING
Conditions: Mental Health Issue|Substance Use Disorders|Distress, Emotional
Interventions: BEHAVIORAL: Basic Case Management|BEHAVIORAL: Basic Case Management plus Distress Tool|BEHAVIORAL: Basic Case Management plus rapid mental health & addictions healthcare access|BEHAVIORAL: Basic Case Management plus Distress Tool and rapid mental health & addictions healthcare access
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase 1, Open-label, Single Dose Study to Examine Safety, Tolerability, Pharmacokinetics and Virologic Impact of VRC01LS or VRC07-523LS in HIV-infected Viremic Adults
Status: COMPLETED
Conditions: HIV-1
Interventions: BIOLOGICAL: VRC-HIVMAB080-00-AB|BIOLOGICAL: VRC-HIVMAB075-00-AB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial of HMR(Home Meal Replacement)-Type Omega-3-balanced-diet
Status: UNKNOWN
Conditions: Chronic Metabolic Disorder|Lipid Metabolism Disorders|Sarcopenia
Interventions: DIETARY_SUPPLEMENT: HMR(Home meal replacement)-type omega-3-balanced diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chronic Myelogenous Leukemia (CML) - Follow on: Study of BMS-354825 in Subjects With CML
Status: COMPLETED
Conditions: Myeloid Leukemia, Chronic, Chronic-Phase
Interventions: DRUG: dasatinib|DRUG: dasatinib|DRUG: dasatinib|DRUG: dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imaging [18F]PI-2620 and [18F]Florbetaben in Military Service Members With Blast Related Mild Traumatic Brain Injury
Status: TERMINATED
Conditions: Mild Traumatic Brain Injury
Interventions: DRUG: [18F]PI-2620
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Stereotactic Boost and Short-course Radiation Therapy for Oropharynx Cancer
Status: RECRUITING
Conditions: Head and Neck Cancer|Oropharynx Cancer|Human Papilloma Virus
Interventions: RADIATION: SABR boost and de-escalated chemoradiation|RADIATION: Standard chemoradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-Drug Analgesia vs. Standard Solution for Anal Surgery
Status: WITHDRAWN
Conditions: Hemorrhoids|Fissure in Ano|Fistula;Rectal
Interventions: DRUG: Multi-drug local anesthetics (Combination)|DRUG: Standard local anesthetics (Combination)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment of Sarcopenia at Diagnosis for Patients With Previously Untreated Metastatic Cancer or Hematologic Malignancy
Status: UNKNOWN
Conditions: Metastatic Cancer|Cancer, Breast|Cancer Colon|Cancer, Rectum|Cancer, Lung|Cancer Ovaries|Cancer Prostate|Cancer, Kidney|Cancer Pancreas|Myeloma|Myelodysplasia|Leukemia, Myeloid, Acute|Leukemia,Myeloid, Chronic|Leukemia, Lymphocytic, Acute|Leukemia, Lymphocytic, Chronic
Interventions: OTHER: Standard
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bispecific PSMAxCD3 Antibody CC-1 in Patients With Squamous Cell Carcinoma of the Lung
Status: TERMINATED
Conditions: Lung Cancer Squamous Cell
Interventions: DRUG: CC-1 and Toczilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cangrelor in ST-Elevation Myocardial Infarction to Decrease Infarct Size
Status: TERMINATED
Conditions: STEMI - ST Elevation Myocardial Infarction
Interventions: DRUG: Cangrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Functional Outcomes 2 Years After ACL Repair and InternalBrace Ligament Augmentation in Comparison With ACL Reconstruction
Status: COMPLETED
Conditions: Injury of the Anterior Cruciate Ligament (ACL)
Interventions: OTHER: collection of Patient Reported Outcome (PRO) data|OTHER: collection of anthropometric and clinical functional data|OTHER: gait analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetic Interaction Study to Assess the Effect of ASP015K on Tacrolimus in Healthy Volunteers
Status: COMPLETED
Conditions: Pharmacokinetics of ASP015K|Drug Interactions|Healthy Subjects
Interventions: DRUG: ASP015K|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Study of Cadonilimab Combined With Bevacizumab and Standard Chemotherapy as First Line Therapy in Unresectable Pleural Mesothelioma
Status: RECRUITING
Conditions: Pleural Mesothelioma
Interventions: DRUG: Cadonilimab+Bevacizumab+Pemetrexed+Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Efficacy Study Looking at a Single-dose of One of Three Dose Levels of AIN457 in Patients With Chronic Plaque-type Psoriasis
Status: COMPLETED
Conditions: Chronic Plaque Psoriasis
Interventions: BIOLOGICAL: AIN457|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Amifostine to Protect the Rectum During External Beam Radiotherapy for Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: Amifostine trihydrate|RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study ATG-101 in Patients With Metastatic/Advanced Solid Tumors and Mature B-cell Non-Hodgkin Lymphomas
Status: RECRUITING
Conditions: Advanced Solid Tumor|Metastatic Solid Tumor|Mature B-cell Non-Hodgkin Lymphoma
Interventions: DRUG: ATG-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studies of the Ocular Complications of AIDS (SOCA) CMV Retinitis Trial: Foscarnet-Ganciclovir Component
Status: COMPLETED
Conditions: Cytomegalovirus Retinitis|HIV Infections
Interventions: DRUG: Foscarnet sodium|DRUG: Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Trial of Prostate Cancer Patients Undergoing Active Surveillance With or Without MRI-Guided Management
Status: WITHDRAWN
Conditions: Prostate Cancer|Prostate Adenocarcinoma
Interventions: PROCEDURE: Transrectal Ultrasound-Guided Biopsy|PROCEDURE: MRI Ultrasound Biopsy|BEHAVIORAL: Expanded Prostate Cancer index Composite Questionnaire|BEHAVIORAL: Short-Form 12 of Health Related Quality of Life Questionnaire|BEHAVIORAL: Memorial Anxiety Scale for Prostate Cancer|PROCEDURE: Plasma/Serum Sample for biomarkers|PROCEDURE: Urine Sample for Biomarkers|PROCEDURE: Blood Tests for Blood Urea Nitrogen and Creatinine|PROCEDURE: Blood Test for Serum PSA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Accelerated, Theta-burst Stimulation for the Treatment of Post-concussion Syndrome - Open-label Pilot Study
Status: RECRUITING
Conditions: Post-Concussion Syndrome
Interventions: DEVICE: Intermittent Theta-Burst Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Upper Limb Somatosensory Discrimination Therapy and Dose-matched Motor Therapy in Children and Adolescents With Unilateral Cerebral Palsy
Status: RECRUITING
Conditions: Cerebral Palsy, Spastic|Hemiplegic Cerebral Palsy
Interventions: BEHAVIORAL: Upper limb somatosensory discrimination therapy|BEHAVIORAL: Upper limb motor therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Sorafenib and Bi-weekly Capecitabine in Patients With Advanced Breast and Gastrointestinal Tumors
Status: COMPLETED
Conditions: Metastatic Breast Cancer|Gastrointestinal Tumors
Interventions: DRUG: Sorafenib|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peri-implant Soft Tissue Conditioning of Immediate Posterior Implants by CAD/CAM Socket Sealing Abutments
Status: COMPLETED
Conditions: Implant Site Reaction
Interventions: PROCEDURE: cad/cam socket sealing abutment|PROCEDURE: standard healing abutment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Protein Intake in Older Americans With Mobility Limitations
Status: COMPLETED
Conditions: Mobility Limitation
Interventions: DRUG: Testosterone enanthate|DRUG: Testosterone enanthate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Family Supports and Beliefs Survey
Status: COMPLETED
Conditions: Beliefs About Child Development
Interventions: BEHAVIORAL: Low SES/High Supports|BEHAVIORAL: Low SES/ Low Supports|BEHAVIORAL: High SES/High Supports|BEHAVIORAL: High SES/Low Supports
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effects of Transcranial Direct Current Stimulation (tDCS) and Visual Illusion on Chronic Pain Due to Spinal Cord Injury
Status: TERMINATED
Conditions: Chronic Pain|Spinal Cord Injury
Interventions: PROCEDURE: Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Radiation and Nivolumab in the Management of Metastatic Breast Cancer Brain Metastases
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Breast Cancer|Brain Metastases
Interventions: DRUG: Nivolumab|RADIATION: Stereotactic Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Improved Wound Healing and Protein Synthesis of Insulin and Metformin
Status: TERMINATED
Conditions: Insulin Resistance|Hypermetabolism|Hyperglycemia
Interventions: DRUG: Metformin|DRUG: Sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Xenon as an Adjuvant to Propofol Anaesthesia in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery.
Status: COMPLETED
Conditions: Coronary Artery Disease|Anesthesia
Interventions: DRUG: Xenon and propofol|DRUG: propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Step-up to Quit: Using Low-to-moderate Intensity Exercise for Reducing Smoking Cue Reactivity Among Low-income Smokers
Status: UNKNOWN
Conditions: Sedentary Lifestyle|Cigarette Smoking
Interventions: BEHAVIORAL: PA+ Smoking Cessation (LMPA)|BEHAVIORAL: Standard Care Smoking Counseling (SCC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects Resistance Training on Motor Control and Cognition
Status: COMPLETED
Conditions: Muscle Weakness
Interventions: OTHER: Stable Resistance Training|OTHER: Unstable Resistance Training|OTHER: Adductor/Abductor Resistance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Livoletide (AZP-531) on Food-related Behaviors in Patients With Prader-Willi Syndrome
Status: TERMINATED
Conditions: Prader-Willi Syndrome|Hyperphagia
Interventions: DRUG: Livoletide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety and Efficacy of Lebrikizumab in Adult and Adolescent Participant With Moderate-to-Severe Atopic Dermatitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Atopic Dermatitis
Interventions: BIOLOGICAL: Lebrikizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of TRC105 in Metastatic Castrate Resistant Prostate Cancer (CRPC)
Status: COMPLETED
Conditions: Prostate Cancer|Metastatic Castrate Resistant Prostate Cancer
Interventions: DRUG: TRC105
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FOCUS Guidelines and Adherence to Physical Activity in Ageing Women.
Status: COMPLETED
Conditions: Frail Elderly Syndrome|Mood|Quality of Life|Cognitive Decline|Social Interaction|Adherence, Patient
Interventions: OTHER: Physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase I Study of Bendamustine and Melphalan Conditioning and Autologous Stem Cell Transplantation for Treatment of Multiple Myeloma and Relapsed/Refractory B-cell Lymphoma in Elderly Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma
Interventions: DRUG: rituximab|DRUG: bendamustine|DRUG: melphalan|PROCEDURE: Autologous Stem Cell Transplantation (ASCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine and Doxorubicin in Treating Patients With Recurrent or Progressive Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: doxorubicin hydrochloride|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Letrozole Versus Hormonal Preparation in Frozen Cycles of PCOS Patients.
Status: WITHDRAWN
Conditions: Frozen Embryo Transfer|Polycystic Ovarian Disease|Letrozole|Hormone Replacement Therapy|Live Birth|Miscarriage
Interventions: DRUG: Letrozole 2.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robotic Assisted Early Mobilization in Ventilated ICU Patients With COVID-19
Status: COMPLETED
Conditions: Covid19|Critical Illness|Critical Illness Polyneuromyopathy|Early Mobilization|Rehabilitation|Robotics
Interventions: DEVICE: Robotic assisted early mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positive Psychology Intervention to Treat Diabetes Distress in Teens With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: BEHAVIORAL: Positive Affect + Education|BEHAVIORAL: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ-79032421 Targeting Mesothelin for Advanced Stage Solid Tumors
Status: RECRUITING
Conditions: Advanced Stage Solid Tumors
Interventions: DRUG: JNJ-79032421|DRUG: JNJ-79032421
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Cohort of Patients With Systemic Sclerosis at Brest University Hospital With Biobanking
Status: RECRUITING
Conditions: Systemic Sclerosis
Interventions: OTHER: Blood samples|OTHER: Stool samples|OTHER: Skin swab samples|OTHER: Questionnaires on quality of life, pain and disability|OTHER: Skin biopsies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fed Study of Anagrelide Hydrochloride Capsules 1 mg to Agrylin® Capsules 1 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Anagrelide Hydrochloride Capsules 1 mg|DRUG: Agrylin® Capsules 1 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Combination Chemotherapy Plus Rituximab in Treating Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: carboplatin|DRUG: etoposide|DRUG: ifosfamide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of Efficacy and Safety of PHP-201 in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
Status: UNKNOWN
Conditions: Primary Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Placebo ophthalmic solution|DRUG: PHP-201 ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Awake Endotracheal Intubation in Cervical Injury
Status: NOT_YET_RECRUITING
Conditions: Trauma|Patient Satisfaction|Airway Morbidity
Interventions: DRUG: sedative|DEVICE: Awake endotracheal intubation by Glidescope videolaryngoscope|DEVICE: Awake endotracheal intubation by Fiberoptic bronchoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Immediate Implant Placement Utilizing Vestibular Flap Versus Single Flap Approach With Bone Graft
Status: NOT_YET_RECRUITING
Conditions: Immediate Implant Placement
Interventions: PROCEDURE: Vestibular Flap Group|PROCEDURE: Single Flap Approach group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topotecan and Paclitaxel in Treating Patients With Recurrent or Metastatic Cancer of the Cervix
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: paclitaxel|DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Confirmatory Trial of Multidisciplinary Digital Therapeutics for Patellofemoral Pain Syndrome
Status: RECRUITING
Conditions: Patellofemoral Pain Syndrome
Interventions: DEVICE: MORA Cure|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycocalyx Biomarkers in ARDS for Clinical Prognosis and Pulmonary Fibrosis
Status: UNKNOWN
Conditions: ARDS, Human|Endothelial Dysfunction|Mechanical Ventilation Pressure High
Interventions: DIAGNOSTIC_TEST: Glycocalyx measurement，respiratory mechanics measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Postoperative Analgesia After Elective Hip Surgery - Effect of Obturator Nerve Blockade
Status: COMPLETED
Conditions: Obturator Nerve Block|Total Hip Replacement
Interventions: DRUG: Bupivacaine-epinephrine|PROCEDURE: Sham block|PROCEDURE: Obturator nerve block|DRUG: Sodium Chloride 9mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Newly Diagnosed Moderate or Severe Chronic Graft-versus-host Disease With Prednisone and Everolimus
Status: COMPLETED
Conditions: Chronic Graft-versus-host Disease
Interventions: DRUG: PredEver
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Delivery of Soluble Ferric Pyrophosphate (SFP) Via the Dialysate to Maintain Iron Balance in Hemodialysis Patients
Status: TERMINATED
Conditions: End Stage Renal Disease (ESRD)
Interventions: DRUG: soluble ferric pyrophosphate (SFP)|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: BeWell360-CG Care Model: Health and Wellness Coaching to Support Caregivers of Patients Living With Advanced Lung Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lung Carcinoma|Stage III Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8
Interventions: OTHER: Best Practice|OTHER: Educational Intervention|OTHER: Health Promotion and Education|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chronic Care Management With Wearable Devices in Patients Prescribed Positive Airway Pressure Therapy (mPAP) Trial
Status: RECRUITING
Conditions: Obstructive Sleep Apnea
Interventions: BEHAVIORAL: Immediate Intervention|BEHAVIORAL: Waitlist control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pralatrexate and Fluorouracil in Treating Patients With Recurrent Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: pralatrexate|DRUG: fluorouracil|OTHER: laboratory biomarker analysis|GENETIC: DNA analysis|OTHER: high performance liquid chromatography|GENETIC: polymerase chain reaction|GENETIC: nucleic acid sequencing|OTHER: pharmacological study|OTHER: pharmacogenomic studies|GENETIC: polymorphism analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety and Efficacy of OTX-DP for the Treatment of Allergic Conjunctivitis
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: Dexamethasone, 0.4mg|DEVICE: Placebo plug with no drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Clinical Trial Combining hTERT Tumor Vaccine & Autologous T Cells in Patients With Advanced Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: hTERT vaccine, GM-CSF, PCV, T cell infusion|BIOLOGICAL: GM-CSF, PCV, T cell infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT