pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Antidepressant Adherence for Depressed Adults in Primary Care
Status: NOT_YET_RECRUITING
Conditions: Depression
Interventions: BEHAVIORAL: Reminders|BEHAVIORAL: Incentives
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Cardiopulmonary Fitness Level With Normal Values After COVID-19
Status: RECRUITING
Conditions: COVID 19
Interventions: OTHER: Physical Activity Level|OTHER: Anxiety and Depression Assessment|DIAGNOSTIC_TEST: Exercise Capacity|DIAGNOSTIC_TEST: Pulmonary Function Test|DIAGNOSTIC_TEST: Cardiopulmonary Fitness Level|OTHER: Cognitive Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase III Study of SP2086 in Combination With Metformin in Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: Placebo/Metformin|DRUG: SP2086 50 mg b.i.d/Metformin|DRUG: SP2086 50 mg q.d./Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of a Point-of-care Device Measuring Ferritin With Capillary Blood
Status: WITHDRAWN
Conditions: Anemia, Iron Deficiency|Iron Overload|Iron-deficiency
Interventions: DIAGNOSTIC_TEST: Point of care ferritin test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phenotypic Profile and Molecular Mechanism of Resistance in Carbapenemase-producing Enterobacterales and Pseudomonas Aeruginosa Isolates From Brazilian Hospitals: Implications for the Introduction of IMIPENEM-RELEBACTAM
Status: UNKNOWN
Conditions: Bacterial Infections|Antibiotic Resistant Infection
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate MK0476 and Fluticasone to Control Asthma in Patients With Mild Persistent Asthma (0476-910)
Status: COMPLETED
Conditions: Asthma, Bronchial
Interventions: DRUG: MK0476, montelukast sodium / Duration of Treatment: 1 Year|DRUG: Comparator : fluticasone propionate / Duration of Treatment: 1 Year
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic TAP Block During Robotic Assisted Laparoscopic Radical Prostatectomy for Improvement in Postoperative Pain
Status: ENROLLING_BY_INVITATION
Conditions: Prostate Cancer
Interventions: DRUG: Early TAP Block|DRUG: Late TAP Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ITI-214 in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: ITI-214|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Trial To Evaluate the Safety and Immunogenicity of the UBI HIV-1MN PND Peptide Immunogen, Given by IM Injection, in Combination With the UBI Microparticulate Monovalent HIV-1 MN Branched Peptide Given Orally, in HIV-1 Uninfected Volunteers.
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: HIV-1 Peptide Vaccine, Microparticulate Monovalent|BIOLOGICAL: HIV-1 Peptide Immunogen, Multivalent
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Phase II Avastin Trial for Stage IIIB/IV NSCLC
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer Stage IIIB|Non-small Cell Lung Cancer Stage IV
Interventions: DRUG: bevacizumab|DRUG: docetaxel|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An In-home Respite Care Program to Support Informal Caregivers of People With Dementia
Status: COMPLETED
Conditions: Dementia
Interventions: OTHER: in-home respite care program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Opiate Craving Reduction Study Using Post-detox Patients on Suboxone and Use of TEAS as Adjunctive Treatment
Status: WITHDRAWN
Conditions: Opioid-use Disorder
Interventions: DEVICE: Han's Acupoint Nerve Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Analysis of the Mechanisms of Actions of Heat Shock Protein (Hsp27) Responsible of the Androgen-independent Evolution in Prostate Cancer
Status: TERMINATED
Conditions: Androgen-independent Prostate Cancer
Interventions: PROCEDURE: Realisation of blood sample, urinary sample and tumor biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Postoperative TACE(Transhepatic Arterial Chemotherapy And Embolization) for Patients With Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Transcatheter Arterial Chemoembolization
Interventions: DRUG: Prophylactic Transcatheter Arterial Chemoembolization|OTHER: Observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PD-1 Inhibitor Combined With Neoadjuvant Chemoradiotherapy Plus Surgery for Locally Advanced ESCC (NEOCRTEC2101)
Status: RECRUITING
Conditions: Squamous Cell Esophageal Carcinoma|Esophageal Cancer|Oesophageal Cancer
Interventions: DRUG: Sintilimab|RADIATION: Preoperative radiotherapy|DRUG: Paclitaxel|DRUG: Cisplatin|PROCEDURE: esophagectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UCMSC-Exo for Chemotherapy-induced Myelosuppression in Acute Myeloid Leukemia
Status: NOT_YET_RECRUITING
Conditions: Acute Myeloid Leukemia|Neutropenia|Anemia|Thrombocytopenia|Infections|Bleeding
Interventions: BIOLOGICAL: umbilical cord derived mesenchymal stem cells exosomes (UCMSC-Exo)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Discriminative Effects of Tramadol in Humans
Status: COMPLETED
Conditions: Opioid Abuse|Opioid Addiction|Stimulant Abuse|Stimulant Addiction
Interventions: DRUG: tramadol|DRUG: placebo|DRUG: Hydromorphone|DRUG: Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Sertraline-reboxetine Combination Therapy Versus Sertraline or Reboxetine Monotherapy in the Treatment of Major Depression.
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: sertraline/[S,S]-reboxetine|DRUG: sertraline/[S,S]-reboxetine|DRUG: sertraline|DRUG: sertraline|DRUG: sertraline/[S,S]-reboxetine|DRUG: Placebo|DRUG: sertraline/[S,S]-reboxetine|DRUG: [S,S]-reboxetine monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Essential Oils as Adjutants on the Treatment of Subjects With Periodontitis: Assessment of Metabolic Variables as Effect Modifiers
Status: TERMINATED
Conditions: Periodontitis
Interventions: OTHER: Plant-based oral rinse|OTHER: Placebo oral rinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety and Tolerability of Idalopirdine (Lu AE58054) as Adjunctive Treatment to Donepezil in Patients With Mild-moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Idalopirdine 60 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of STA-1 as an Add-on Treatment to Donepezil
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: DRUG: Donepezil,|DRUG: STA-1|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is Clonal Hematopoiesis of Indeterminate Potential Associated With Unprovoked Pulmonary Embolism?
Status: RECRUITING
Conditions: Pulmonary Embolism|Hematopoiesis
Interventions: BIOLOGICAL: blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Open-label Extension Study of Brazikumab in Ulcerative Colitis
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: DRUG: Brazikumab Maintenance Dose|DRUG: Brazikumab Induction Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individual Differences in Drug Response
Status: COMPLETED
Conditions: Differential Female Response to Δ9-tetrahydrocannabinol (THC)
Interventions: DRUG: Dronabinol|DRUG: dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy Study of Sofpironium Bromide in Subjects With Axillary Hyperhidrosis (BBI-4000-CL-302)
Status: COMPLETED
Conditions: Axillary Hyperhidrosis
Interventions: DRUG: Sofpironium Bromide, 15%|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GIST in Hematopoietic Stem Cell Transplantation/Bone Marrow Transplantation
Status: WITHDRAWN
Conditions: Liquid Tumor|Cancer|Psychological Feedback
Interventions: BEHAVIORAL: GIST
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Meal-Time Dosing of Insulin in Cystic Fibrosis Related Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Cystic Fibrosis-related Diabetes
Interventions: DRUG: Insulin|DEVICE: Continuous glucose monitor (CGM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-intensity Shockwave Therapy (LiST) for the Treatment of Mild and Mild-to-moderate Vasculogenic Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction|Low Intensity Shockwave Therapy
Interventions: OTHER: DornierAries2 LiST device + 5 mg Tadalafil|OTHER: DornierAries2 LiST device + Placebo Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Clinical Trial of DA-5207 in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Aricept 5mg Tablet|DRUG: Aricept 10mg Tablet|DRUG: DA-5207 A|DRUG: DA-5207 B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hepatic Arterial Infusion With FOLFOX Alone or in Combination With IV Chemotherapy in Colon Cancer With Liver Metastasis
Status: WITHDRAWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Oxaliplatin|DRUG: Folinic Acid|DRUG: 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inositols and FSH in IVF
Status: UNKNOWN
Conditions: Amount of FSH Units During Ovarian Stimulation Protocols
Interventions: DIETARY_SUPPLEMENT: D-chiro-inositol|DIETARY_SUPPLEMENT: Myo-inositol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Covered Metal Ureteral Stents in the Treatment of Benign Short Ureteral Stricture
Status: NOT_YET_RECRUITING
Conditions: Ureteral Stenosis
Interventions: DEVICE: Covered metal ureteral stents|DEVICE: Tandem DJ stents
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pemziviptadil (PB1046), a Long-acting, Sustained Release Human VIP Analogue, Intended to Provide Clinical Improvement to Hospitalized COVID-19 Patients at High Risk for Rapid Clinical Deterioration and Acute Respiratory Distress Syndrome (ARDS).
Status: TERMINATED
Conditions: Acute Respiratory Distress Syndrome|Coronavirus|Hypoxic Respiratory Failure|Hypoxemic Respiratory Failure|Respiratory Complication|Respiratory Insufficiency|Cardiac Dysfunction|Pneumonia|Pulmonary Edema|Pulmonary Inflammation|Respiratory Failure|Cytokine Storm|COVID 19|SARS-CoV-2|Cardiac Event|Cardiac Complication|Cardiac Failure|Cardiac Infarct
Interventions: DRUG: Pemziviptadil (PB1046)|DRUG: Low Dose (10 mg) Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Doxazosin an a1 Antagonist for Alcohol Dependence
Status: COMPLETED
Conditions: Alcohol Dependence|Anxiety
Interventions: DRUG: Doxazosin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SI-6603 Versus Placebo in Patients With Lumbar Disc Herniation
Status: COMPLETED
Conditions: Lumbar Vertebra Hernia
Interventions: DRUG: SI-6603|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 36 Weeks Short-Term Optimization Treatment of Glucocorticosteroid in the Patients With Chronic Recurrent DILI
Status: COMPLETED
Conditions: Drug-induced Liver Injury,Chronic
Interventions: DRUG: 36 Weeks Methylprednisolone|DRUG: 48 weeks Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Light Therapy for Fatigue N-of-1 Trials
Status: COMPLETED
Conditions: Fatigue
Interventions: DEVICE: Bright Blue Light Commercial AYO Light Therapy Device|DEVICE: Dim Blue Light Commercial AYO Light Therapy Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Protein Supplementation: Body Composition, Muscle Strength and Postural Balance
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Protein Supplementation|Body Composition|Inflammation Biomarkers|Resistance Training
Interventions: DIETARY_SUPPLEMENT: Whey protein|OTHER: Exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sinus Lift: Saving Time and Reducing Morbidity
Status: COMPLETED
Conditions: Tooth Loss|Bone Atrophy
Interventions: PROCEDURE: Sinus floor augmentation (lateral)|PROCEDURE: Sinus floor augmentation (transcrestal)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glutamatergic and GABAergic Mediators of Antidepressant Response in Major Depression
Status: COMPLETED
Conditions: MDD|Citalopram|Major Depressive Disorder
Interventions: DRUG: citalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurocognitive Empowerment for Addiction Treatment (NEAT) in Opioid Use Disorder and Amphetamine Use Disorder
Status: COMPLETED
Conditions: Opioid-use Disorder|Amphetamine Use Disorders
Interventions: BEHAVIORAL: Neurocognitive Empowerment for Addiction Treatment (NEAT)|BEHAVIORAL: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dimensional Model for Personality Disorders in Later Life
Status: RECRUITING
Conditions: Psychiatric Disorders
Interventions: OTHER: PID-5-BF+M and LPFS-BF 2.0 (self-report questionnaires)|OTHER: Secondary Questionnaires (self-report and informant questionnaires)|DIAGNOSTIC_TEST: Clinical Ratings of the dimensional model|OTHER: PID-5-BF+M and LPFS-BF 2.0 (Informant questionnaires)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Randomized Trial of Interventions for Teenage Drivers With Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DEVICE: CarChipPro|BEHAVIORAL: Driver's Education|BEHAVIORAL: STEER Program|OTHER: Driving Simulator Practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study Investigating the Safety, Absorption, and Elimination of Radioactively Labeled Etrumadenant, a New Compound in the Treatment of Cancer
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: [14C]-etrumadenant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of Duvortuxizumab (JNJ-64052781) Plus Ibrutinib in Lymphoma
Status: WITHDRAWN
Conditions: Leukemia, Lymphocytic, Chronic, B-Cell|Lymphoma, Large B-Cell, Diffuse|Lymphoma, Follicular|Lymphoma, Mantle-Cell
Interventions: DRUG: Duvortuxizumab|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of High-dose Vitamin C for Advanced Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Neoplasms|Pancreatic Cancer
Interventions: DRUG: Gemcitabine with escalating ascorbic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combining H1-Coil Deep Transcranial Magnetic Stimulation (dTMS) and App-guided CBT in Subjects With Major Depression Disorder (MDD)
Status: UNKNOWN
Conditions: Data Collection for Facilitation of Machine Learning Algorithm for Personalized Treatment
Interventions: BEHAVIORAL: CBT-based, mobile-delivered, intervention platform
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Zephyrus I: Evaluation of Efficacy and Safety of Pamrevlumab in Participants With Idiopathic Pulmonary Fibrosis (IPF)
Status: TERMINATED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Pamrevlumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of TBX-3400 in Subjects With Solid Malignant Tumors Resistant or Refractory to Standard Therapies
Status: UNKNOWN
Conditions: Cancer|Tumor, Solid|Refractory Cancer
Interventions: BIOLOGICAL: TBX-3400
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of IMM01 Plus Tiselizumab Versus Physician's Choice Chemotherapy in PD(L)1-refractory Classical Hodgkin Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Classic Hodgkin Lymphoma
Interventions: BIOLOGICAL: Tislelizumab|BIOLOGICAL: IMM01|DRUG: Bendamustine|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Helicobacter Pylori Sample Collection Protocol Pre Therapy Subjects
Status: COMPLETED
Conditions: Helicobacter Pylori Infection|Gastric Ulcer|Nausea|Abdominal Pain|Weight Loss|Stomach Ulcer|Loss of Appetite|Bloating
Interventions: OTHER: Newly Diagnosed
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
Status: ENROLLING_BY_INVITATION
Conditions: Congenital Diaphragmatic Hernia
Interventions: DEVICE: BALT GOLDBALL 2 detachable latex ballon|DEVICE: BALTACCIBDPE100 Microcatheter|DEVICE: Storz fetoscopic operating sheath and miniature telescope/fetoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Titration Investigation of the Pharmacokinetics of Testosterone Transdermal Systems in Hypogonadal Men
Status: COMPLETED
Conditions: Hypogonadism
Interventions: DRUG: Testerone Transdermal System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supportive Oncology Care At Home RCT
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer|GastroEsophageal Cancer|Rectal Cancer|Head and Neck Cancer|Lymphoma
Interventions: OTHER: Supportive Oncology Care at Home|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Bispectral Index (BIS™) and Levels of Sedation With Common Inhalational Anesthetics in Healthy Volunteers (OLIVER)
Status: COMPLETED
Conditions: Anesthesia
Interventions: DEVICE: BIS Complete Monitoring System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Yellow 560 Microscope for Intraoperative Visualization of Fluorescein Stained Intracranial Lesions
Status: UNKNOWN
Conditions: Cerebrovascular Disorders|Intracranial Neoplasms
Interventions: DRUG: Fluorescein Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of an Educational Intervention in Exclusive Breastfeeding
Status: UNKNOWN
Conditions: Breastfeeding, Exclusive
Interventions: BEHAVIORAL: Nursing intervention outcome: Breastfeeding Counseling (5244)|BEHAVIORAL: Nursing education about maternal care and usual education in maternity preparation course
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence Study of Entecavir Tablets and Baraclude® Under Fasting Condition in Chinese Healthy Volunteers
Status: COMPLETED
Conditions: Chronic Hepatitis b
Interventions: DRUG: Baraclude® tablets,1.0 mg|DRUG: Entecavir tablets,1.0 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of TPI-287 to Treat CBS and PSP
Status: COMPLETED
Conditions: Primary Four Repeat Tauopathies (4RT)|Corticobasal Syndrome (CBS)|Progressive Supranuclear Palsy (PSP)|Corticobasal Degeneration (CBD)
Interventions: DRUG: TPI 287 2 mg/m2|DRUG: TPI-287 20 mg/m2|DRUG: Placebo|DRUG: TPI-287 6.3 mg/m2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Kinetics and Ecology of Human Papillomavirus Genital Infections in Young Women
Status: TERMINATED
Conditions: HPV Genital Infection (Primary Condition Studied)|Bacterial Vaginosis|Chlamydiae Infection
Interventions: OTHER: vaginal sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Performance Evaluation of LumiraDx COVID-19 (SARS-CoV-2) Ag Test
Status: ACTIVE_NOT_RECRUITING
Conditions: Covid19
Interventions: DIAGNOSTIC_TEST: Nasal Swab|DIAGNOSTIC_TEST: Nasopharyngeal swab|DIAGNOSTIC_TEST: Throat swab|DIAGNOSTIC_TEST: Fingerstick|DIAGNOSTIC_TEST: Saliva specimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of an Enhanced Tobacco Intervention Protocol Compared to Standard Treatment in Helping Head and Neck and Lung Cancer Patients Starting Treatment to Reduce Cigarette Use
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Non-Small Cell Carcinoma|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Nicotine Replacement|DRUG: Bupropion Hydrochloride Controlled-release|DRUG: Varenicline|OTHER: Tobacco Cessation Counseling|OTHER: Questionnaire Administration|OTHER: Quality of Life Assessment|OTHER: Best Practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficiency and Safety of the Drug Ingaron (Interferon-gamma Human Recombinant) in the Treatment of Chronic Prostatitis
Status: COMPLETED
Conditions: Chronic Prostatitis
Interventions: DRUG: Interferon gamma human recombinant (IFN-G)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety of Regorafenib (BAY73-4506) in Cancer Subjects With Severe Renal Impairment
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Regorafenib (Stivarga, BAY73-4506)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Panretinal Photocoagulation (PRP) Plus Ranibizumab for Proliferative Diabetic Retinopathy
Status: COMPLETED
Conditions: Diabetic Retinopathy|Retinal Neovascularization
Interventions: DRUG: Ranibizumab|PROCEDURE: Panretinal Photocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral Parent Training for Families With Deaf and Hard of Hearing Preschoolers
Status: ACTIVE_NOT_RECRUITING
Conditions: Deafness|Hearing Loss|Parenting|Child Behavior
Interventions: BEHAVIORAL: Parent Training Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 2 Study For Patients With A Physician's Diagnosis Of Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Adalimumab|DRUG: CP-690-550|DRUG: CP-690-550|DRUG: CP-690-550|DRUG: CP-690,550|DRUG: CP-690,550|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Implementing a Mental Health Care Program and Home-based Training for Mothers of Children With Autism Spectrum Disorder in an Urban Population in Bangladesh
Status: UNKNOWN
Conditions: Maternal Depression
Interventions: OTHER: Mental Health care services & home based training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Previously Treated Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Neoplasms|Colonic Neoplasms|Rectal Neoplasms
Interventions: DRUG: Vatalanib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Open, Single-dose/-Period Study to Assess Mass Balance Recovery, Metabolite Profile/Identification of 14C-Varlitinib
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Varlitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Feasibility of BabyGentleStick- Adult Pilot Study
Status: COMPLETED
Conditions: Lack of Adverse Events|Reduced Pain Response
Interventions: DEVICE: BabyGentleStick™ ON|DEVICE: BabyGentleStick™ OFF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Treatment of Schizophrenia With an Omega-3 Fatty Acid (EPA) and Antioxidants
Status: COMPLETED
Conditions: Schizophrenia|Schizophreniform Disorders|Schizoaffective Disorder|Psychotic Disorders
Interventions: DRUG: Ethyl-eicosapentaenoic acid (EPA)|DRUG: Vitamins E + C|OTHER: Etyl EPA (placebo)|OTHER: Vitamins E+C (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Realtime-Elastography (RTE) and Thyroid Nodules
Status: COMPLETED
Conditions: Thyroid Nodules
Interventions: DEVICE: Realtime-Elastography, linear ultrasound probe, Hitachi EUB-900, Japan|PROCEDURE: Cytology (FNAB) or Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pilot Study to Determine Radioiodide Accumulation and Dosimetry in Breast Cancers Using 124I PET/CT
Status: TERMINATED
Conditions: Breast Cancer|Breast Cancer Early Stage Breast Cancer (Stage 1-3)|Breast Cancer Metastatic Breast Cancer
Interventions: DRUG: Iodine-124|RADIATION: PET/CT with Iodine-124
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioequivalence Trial of 2 Dose Strengths of BI 201335 NA Soft Gelatine Capsules
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: BI 201335 NA 120 mg capsule|DRUG: BI 201335 NA 120 mg capsule|DRUG: BI 201335 NA 40 mg capsule|DRUG: BI 201335 NA 40 mg capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Effect on Post-prandial Glycemia Safety, and Tolerability of Viaject 7 vs. Lispro Insulin During Subcutaneous Insulin Pump Therapy
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Viaject 7|DRUG: LISPRO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Seven Versus Fourteen Days of Treatment in Uncomplicated Staphylococcus Aureus Bacteremia
Status: UNKNOWN
Conditions: Staphylococcus Aureus Bacteremia
Interventions: DRUG: Antibiotic therapy duration for 7 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Correlation Between the Coronary Stenosis Degree With FFRCT and the Grade of Stable Angina Pectoris
Status: UNKNOWN
Conditions: Coronary Stenosis|Angina Pectoris
Interventions: RADIATION: Computed tomographic angiography of coronary artery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of a Systematic Social Work Driven Approach on Medical Power of Attorney Documentation, Knowledge, Attitudes, and Beliefs in Participants With Stage I-IV Gynecological Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Caregiver|Malignant Female Reproductive System Neoplasm
Interventions: OTHER: Questionnaire Administration|OTHER: Questionnaire Administration|OTHER: Video
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Adult Patients Undergoing Open Colectomy MA402S23B303
Status: COMPLETED
Conditions: Bowel Obstruction
Interventions: DRUG: IV morphine sulfate|DRUG: EXPAREL (bupivacaine liposome injectable suspension)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effectiveness of Oral Health in Improving Dysphagia of Patients After Stroke of Swallowing Function and Oral Health Quality of Life
Status: UNKNOWN
Conditions: Swallowing Disorders|Stroke
Interventions: OTHER: oral care program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: An Investigational Immuno-therapy Study of BMS-986205 Combined With Nivolumab, Compared to Nivolumab by Itself, in Patients With Advanced Melanoma
Status: COMPLETED
Conditions: Melanoma|Skin Cancer
Interventions: DRUG: BMS-986205|BIOLOGICAL: Nivolumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-dose (12 Gy) TSEBT+Vorinostat Versus Low-dose TSEBT Monotherapy in Mycosis Fungoides
Status: TERMINATED
Conditions: Cutaneous Lymphoma|Cutaneous T-cell Lymphoma
Interventions: RADIATION: Total skin electron beam therapy (TSEBT)|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Valiant Thoracic Stent Graft With the Captivia Delivery System in the Treatment of Descending Thoracic Aortic Diseases (VALIANT CAPTIVIA France)
Status: COMPLETED
Conditions: Aortic Aneurysm, Thoracic|Descending Thoracic Aortic Dissection|Penetrating Ulcer|Aorta Thoracic; Traumatic Rupture|Aortic Diseases
Interventions: DEVICE: DTA patients (Valiant)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reducing Prehospital Medication Errors & Time to Drug Delivery by EMS During Simulated Pediatric CPR
Status: COMPLETED
Conditions: Cardiopulmonary Arrest|Resuscitation|Pediatrics|Medication Errors|Emergency Medical Services
Interventions: DEVICE: Mobile device app (PedAMINES™) 1st drug|DEVICE: Mobile device app (PedAMINES™) 2nd drug|DEVICE: Mobile device app (PedAMINES™) 3rd drug|DEVICE: Mobile device app (PedAMINES™) 4th drug|DEVICE: Conventional method 1st drug|DEVICE: Conventional method 2nd drug|DEVICE: Conventional method 3rd drug|DEVICE: Conventional method 4th drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Capmatinib Plus Trametinib for the Treatment of Metastatic Non-small Cell Lung Cancer With MET Exon 14 Skipping Mutation
Status: TERMINATED
Conditions: Metastatic Lung Non-Small Cell Carcinoma|Stage IV Lung Cancer
Interventions: DRUG: Capmatinib|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of YL201 in Patients With mCRPC
Status: RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer (mCRPC)
Interventions: DRUG: YL201 for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Mipomersen (ISIS 301012) As Add-on Therapy in High Risk Hypercholesterolemic Patients
Status: COMPLETED
Conditions: Hypercholesterolemia|Coronary Heart Disease
Interventions: DRUG: Mipomersen sodium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultra-Short Course Bedaquiline, Clofazimine, Pyrazinamide and Delamanid Versus Standard Therapy for Drug-Susceptible TB
Status: RECRUITING
Conditions: Tuberculosis, Pulmonary|HIV
Interventions: DRUG: Bedaquiline|DRUG: Clofazimine|DRUG: Pyrazinamide|DRUG: Delamanid|DRUG: Rifampin|DRUG: Isoniazid|DRUG: Ethambutol|DRUG: Pyrazinamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Omega-3 Fat Emulsion (Omegaven) in Infants With Parenteral Nutrition Associated Liver Disease
Status: COMPLETED
Conditions: Parenteral Nutrition Associated Liver Disease
Interventions: DRUG: Omegaven
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biospecimen Collection in Assessing the Effect of Trametinib With or Without Uprosertib on Biomarkers in Patients With Persistent or Recurrent Endometrial Cancer Enrolled on Trial GOG02290
Status: COMPLETED
Conditions: Recurrent Endometrial Carcinoma
Interventions: PROCEDURE: Biospecimen Collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating Clearance of High-Risk HPV and Safety After Administration of ABI-2280 Vaginal Inserts
Status: RECRUITING
Conditions: Human Papillomavirus Infection
Interventions: DRUG: ABI-2280|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Monoclonal Gammopathy of Undetermined Significance|Smoldering Multiple Myeloma
Interventions: DRUG: Metformin XR|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EFFICACI : EFFicacy of Intravenous Infliximab Versus Vedolizumab After Failure of subCutaneous Anti-TNF in Patients With UlCerative Colitis
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: Infliximab|DRUG: Vedolizumab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Placebo-Controlled, Single-Dose Escalation Phase I Clinical Study to Assess the Safety, Pharmacokinetics, and Immunogenicity of HLX6018 in Healthy Subjects
Status: RECRUITING
Conditions: IPF
Interventions: DRUG: GARP/TGF-β1 monoclonal antibody|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, PD & Efficacy of MT-3724 for the Treatment of Patients With Relapsed or Refractory DLBCL
Status: TERMINATED
Conditions: Non-Hodgkin's B-cell Lymphoma|Leukemia, Lymphocytic, Chronic, B-Cell|Small Lymphocytic Leukemia|Diffuse Large B Cell Lymphoma|Blood Cancer|Hematological Malignancy
Interventions: DRUG: MT-3724 Phase 1|DRUG: MT-3724 Phase 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Tolerability of Treatment With Interleukin-2 in Severe and Resistant Alopecia Areata
Status: TERMINATED
Conditions: Alopecia Areata
Interventions: DRUG: Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blood Glucose Response After Oral Intake of Lactulose in Mildly Constipated Patients With Diabetes Mellitus Type 2
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Lactulose crystals 20 g|DRUG: Lactulose crystals 30 g|DRUG: Lactulose liquid 20 g|DRUG: Lactulose liquid 30 g|DRUG: Glucose|DRUG: Still water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Metabolic Syndrome in Young Patients With Acute Lymphoblastic Leukemia in Remission
Status: COMPLETED
Conditions: Fatigue|Leukemia|Long-term Effects Secondary to Cancer Therapy in Children
Interventions: OTHER: laboratory biomarker analysis|OTHER: metabolic assessment|OTHER: questionnaire administration|PROCEDURE: assessment of therapy complications|PROCEDURE: fatigue assessment and management|PROCEDURE: quality-of-life assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Internet-based Self Applied Treatment Program for Prolonged Grief Disorder (PGD)
Status: UNKNOWN
Conditions: Prolonged Grief Disorder
Interventions: BEHAVIORAL: Internet-based Self Applied Treatment Program|BEHAVIORAL: Videoconference treatment with a therapist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An In Vitro Evaluation of Fracture Resistance of Endodontically Treated Teeth Restored With New Contemporary Core Build-up Materials
Status: COMPLETED
Conditions: Fracture Resistance
Interventions: OTHER: class 1 and class 2 cavity preparation and restored with contemporary materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Busulfan in Treating Children and Adolescents With Refractory CNS Cancer
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Childhood Germ Cell Tumor|Leukemia|Lymphoma|Metastatic Cancer|Retinoblastoma|Sarcoma
Interventions: DRUG: busulfan
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation of Nanodropper-mediated Microdrops vs. Standard Drops of 0.5% Timolol Maleate in Glaucoma Patients
Status: COMPLETED
Conditions: Glaucoma|Glaucoma, Open-Angle|Glaucoma, Primary Open Angle|Glaucoma and Ocular Hypertension|Ocular Hypertension
Interventions: DEVICE: Nanodropper adaptor|OTHER: Original eyedrop bottle/No Nanodropper
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quell Opioid Reduction and Pain Relief in Patients With Cancer
Status: TERMINATED
Conditions: Pain|Metastatic Breast Cancer|Prostate Cancer|Colorectal Cancer
Interventions: DEVICE: Quell|DEVICE: Sham Quell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Electrolyte Profile, Nutritional Status and Ileostomy Formation.
Status: COMPLETED
Conditions: Colorectal Resection|Ileostomy
Interventions: DIETARY_SUPPLEMENT: Oral Ηydration Solution|OTHER: Advise on calculated oral fluid requirements|OTHER: No nutritional advice will be given
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Treatment and Prevention of Anemia With Ferrous Sulfate Plus Folic Acid in Children in Goiania - Goias, Brazil
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: ferrous sulfate|DRUG: folic acid|DRUG: placebo (folic acid)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Impact of Palliative Catheter Placement on the Quality of Life of Patients With Refractory Ascites
Status: COMPLETED
Conditions: Ascites
Interventions: BEHAVIORAL: McGill Quality of Life Questionnaire and the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficiency and Safety Study of Pegylated Somatropin to Treat Growth Hormone Deficiency Children
Status: COMPLETED
Conditions: Growth Hormone Deficiency
Interventions: DRUG: pegylated Somatropin|DRUG: pegylated Somatropin|DRUG: Jintropin AQ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Comparison Of All FK-506 Formulations
Status: COMPLETED
Conditions: Renal Failure
Interventions: DRUG: Prograf vs Envarsus XR vs Astagraf XL|DRUG: Prograf vs Astagraf XL vs Envarsus XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety Study of Subcutaneous Ig NextGen 16% in Patients With Primary Immunodeficiency
Status: COMPLETED
Conditions: Primary Immune Deficiency
Interventions: DRUG: Immunoglobulin G (Ig NextGen 16%)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
Status: RECRUITING
Conditions: Depression|Depressive Disorder|Major Depressive Disorder|Major Depressive Episode|Depressive Symptoms|Anhedonia
Interventions: OTHER: cross-sectional MRI and EEG assessments (NO INTERVENTION)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hypnotics to Improve Polysomnography Yield: Eszopiclone vs Ramelteon?
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: Rozerem (Ramelteon)|DRUG: Lunesta (Eszopiclone)|OTHER: Historical Controls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Nasal Insulin to Fight Forgetfulness - Long-acting Insulin Detemir - 120 Days (SL120)
Status: COMPLETED
Conditions: Alzheimer's Disease|Mild Cognitive Impairment
Interventions: DRUG: Saline|DRUG: Insulin detemir|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Phacoemulsification on Intraocular Pressure in Primary Angle Closure Glaucoma (PACG) Patients At Phanat Nikhom Hospital, Chonburi Province
Status: COMPLETED
Conditions: Primary Angle Closure Glaucoma
Interventions: DEVICE: Phacoemulsification machine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p