pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Investigate Safety, Tolerability, and Pharmacokinetics of Oral Doses of TCK-276 in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: TCK-276|DRUG: TCK-276 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Rituximab in Treating Patients With Newly Diagnosed Primary CNS Lymphoma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Lymphoma
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: rituximab|DRUG: cytarabine|DRUG: etoposide phosphate|DRUG: leucovorin calcium|DRUG: methotrexate|DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety of CNTO 1959 (Guselkumab) in Participants With Moderate to Severe Plaque-type Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: CNTO 1959 50 mg|DRUG: CTNO 1959 100 mg|DRUG: Placebo 50 mg|DRUG: Placebo 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Ipilimumab After Prior Immunotherapy for Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: DRUG: Pembrolizumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Cupping Therapy Combined With Conventional Physical Therapy Improves Pain and Health Related Quality of Life Among Female Patients of Low Back Pain''
Status: COMPLETED
Conditions: Low Back Pain
Interventions: PROCEDURE: Mckenzie Extension Protocol|PROCEDURE: Cupping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Nicotine Influence on the Retina Following the Use of Electronic Cigarette
Status: COMPLETED
Conditions: Electronic Cigarette Use|Retina; Change
Interventions: DEVICE: RETI-port/scan 21|DEVICE: Zilia Ocular|DEVICE: OCT-A|COMBINATION_PRODUCT: Electronic cigarette without nicotine|COMBINATION_PRODUCT: Electronic cigarette with nicotine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Fish Oil or Olive Oil Supplementation on the Health Effects of Ozone Exposure in Healthy Young Subjects
Status: COMPLETED
Conditions: Healthy|Dietary Supplement
Interventions: DRUG: Ozone|DIETARY_SUPPLEMENT: Fish Oil|DIETARY_SUPPLEMENT: Olive Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PMCF Study of the AchilloCordPLUS System Implant Set for Acute Achilles Tendon Repair
Status: ACTIVE_NOT_RECRUITING
Conditions: Achilles Tendon Rupture
Interventions: DEVICE: AchilloCordPLUS™ System Implant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Buprenorphine Transdermal System (BTDS) in Subjects With Moderate to Severe Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: Buprenorphine transdermal system|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interventional Clinical Trial in Patients in Overactive Bladder With Nocturia in Women
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: Tolterodine tartrate extended release capsules|DRUG: Desmopressin orally disintegrating tablets|DRUG: Placebo orally disintegrating tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of OROSARTAN® Versus CODIOVAN® in Patients With Essential Hypertension Uncontrolled With Monotherapy
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: OROSARTAN® 5/160mg|DRUG: CODIOVAN® 160/12.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Incidence of EGFR Mutation in Patients With Newly Diagnosed Locally Advanced or Metastatic Non-Small Cell Lung Cancer in the UK, And of Tarceva (Erlotinib) as First-Line Therapy in EGFR Mutation Positive Patients.
Status: COMPLETED
Conditions: Non-Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: erlotinib [Tarceva]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acceptability of a Microbiome-directed Food in Young Children With Acute Malnutrition
Status: COMPLETED
Conditions: Malnutrition, Child
Interventions: DIETARY_SUPPLEMENT: MDF then RUTF/RUSF|DIETARY_SUPPLEMENT: RUTF/RUSF then MDF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Oxiris® Membrane on Microcirculation Following Cardiac Surgery Under Cardiopulmonary Bypass: a Pilot Prospective Monocentric Study (Oxicard Study).
Status: RECRUITING
Conditions: Surgery|Cardiac Event
Interventions: DEVICE: Oxiris
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Technical Feasibility Evaluation of Mucosal Staining During Colon Capsule Endoscopy (CCE) Procedure in Colorectal Cancer (CRC) High Risk Population, When Using MB-MMX
Status: COMPLETED
Conditions: Colorectal Cancer|Polyp, Colonic
Interventions: DEVICE: PillCam Colon2 procedure with MB-MMX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Developing a Text-Message Enhanced Physical Activity Intervention for Latino Men
Status: COMPLETED
Conditions: Inactivity
Interventions: BEHAVIORAL: Text-Enhanced Physical Activity Intervention Arm|BEHAVIORAL: Health Education Control Arm|DEVICE: Actigraph GT3X
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Ketamine Versus Lidocaine for Mid-Sternotomy
Status: UNKNOWN
Conditions: Sternotomy
Interventions: DRUG: lidocaine|DRUG: ketamine|DRUG: non-drug cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paralysis of the Orbicularis Muscle of the Eye in the Treatment for Dry Eye
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: Botulinum toxin type A injection|OTHER: Saline solution injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Improved Preparation Time to a Coverage in Patients With Acute Wounds by Use of VistaCare® Versus Dressings
Status: UNKNOWN
Conditions: Leg Injury
Interventions: DEVICE: VistaCare®|DEVICE: Dressings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b Study of Atezolizumab in Combination With Erlotinib or Alectinib in Participants With Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Alectinib|DRUG: Atezolizumab|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online Contingent Attention Training (OCAT)
Status: WITHDRAWN
Conditions: Major Depression in Remission
Interventions: BEHAVIORAL: OCAT-only|BEHAVIORAL: OCAT-sham|BEHAVIORAL: OCAT-combo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: To Compare the Efficacy and Safety of Tripterygium Wilfordii (TW) Versus Valsartan in the Membranous Nephropathy (MN)
Status: COMPLETED
Conditions: Membranous Nephropathy
Interventions: DRUG: TW
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Flexibility Training Versus Static Stretching on Hamstring Muscle Length and Patterns of Lumbar Flexion
Status: COMPLETED
Conditions: Static Stretching|Dynamic Stretching|Muscle|Low Back
Interventions: BEHAVIORAL: Mobility of the hamstrings muscles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: German Spondyloarthritis Inception Cohort
Status: RECRUITING
Conditions: Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA)|Non-radiographic Axial Spondyloarthritis (Nr-axSpA)|Axial Psoriatic Arthritis (axPsA)|Acute Anterior Uveitis (AAU)|Crohn Disease (CD)|Ulcerative Colitis (UC)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sensory Reconstruction of Finger Pulp Defect Using a Dorsal Digital Island Flap
Status: COMPLETED
Conditions: Trauma
Interventions: PROCEDURE: Sensate Dorsal Digital Island Flap
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Addition of Pyridostigmine to Conventional Management of Postdural Puncture Headache
Status: COMPLETED
Conditions: Postdural Puncture Headache
Interventions: DRUG: Pyridostigmine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Absorbable Suture Versus a Non-absorbable Suture in Carpal Tunnel Release, a Randomized Controlled Trial
Status: RECRUITING
Conditions: Carpal Tunnel Syndrome|Median Nerve Entrapment
Interventions: PROCEDURE: Surgical wound closed with an absorbable suture|PROCEDURE: Surgical wound closed with a non-absorbable suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transarterial Embolization Alone Versus Drug-Eluting Beads Chemoembolization for Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Carcinoma, Hepatocellular
Interventions: COMBINATION_PRODUCT: DEB-TACE|DEVICE: TAE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of MDMA on Social and Emotional Processing
Status: COMPLETED
Conditions: Drug Addiction
Interventions: DRUG: Within-subjects (MDMA)|DRUG: Within-subjects (oxytocin)|DRUG: Within-subjects (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Tolerability of the Use of Varicell Compared With Daflon
Status: UNKNOWN
Conditions: Chronic Venous Insufficiency|Hemorrhoids
Interventions: DRUG: Daflon|DRUG: Varicell placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomised Controlled Trial Between Two Different HDR Brachytherapy Schedule in Locally Advanced Carcinoma of Uterine Cervix
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of Cervix
Interventions: RADIATION: HDR Brachytherapy of 9 Gy in 2 fractions|RADIATION: HDR Brachytherapy of 7 Gy in 3 fractions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clofarabine and Cytarabine in Treating Young Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: clofarabine|DRUG: cytarabine|DRUG: methotrexate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Tislelizumab Combined With Sitravatinib as Adjuvant Therapy in Participants With HCC at High Risk of Recurrence After Curative Resection
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Tislelizumab + Sitravatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective, Randomized, Open Label Controlled Trial To Evaluate The Safety And Efficacy Of Dexmedetomidine Use Beyond 24 Hours Compared With Midazolam In Children Admitted To Pediatric Intensive Care Unit at King Abdullah Specialist Children Hospital- Ministry of National Guard Health Affairs.
Status: RECRUITING
Conditions: Dexmedetomidine|Midazolam|Withdrawal Symptoms|Failure of Extubation
Interventions: DRUG: Dexmedetomidine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Encouraging Overdue Healthcare Appointment Scheduling Among Patients With Chronic Diseases
Status: COMPLETED
Conditions: Health Promotion|Prevention|Risk Reduction Behavior
Interventions: BEHAVIORAL: Outreach mailer|BEHAVIORAL: Humor/Salience|BEHAVIORAL: Doctor's authority|BEHAVIORAL: Information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Single Dose Study Of GW856553 On A Protein That Is An Indicator For Rheumatoid Arthritis (RA)
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: GW856553
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PREDICATE Trial For Respiratory Tract Infections
Status: NOT_YET_RECRUITING
Conditions: Respiratory Tract Infections
Interventions: DRUG: Prednisolone 30 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Ezetimibe Plus Simvastatin Versus Ezetimibe or Simvastatin Alone in Subjects With Primary Hypercholesterolemia (Study P03757)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Ezetimibe + Simvastatin|DRUG: Simvastatin|DRUG: Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Value of Noninvasive Intracranial Pressure Measurement
Status: UNKNOWN
Conditions: Intracranial Hypertension
Interventions: DEVICE: Non-invasive intracranial pressure measurement|DEVICE: Brain MRI/CT|PROCEDURE: Lumbar puncture and cerebrospinal fluid pressure measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Nivolumab (BMS-936558) Plus Ipilimumab Compared With Ipilimumab Alone in the Treatment of Previously Untreated, Unresectable, or Metastatic Melanoma
Status: COMPLETED
Conditions: Unresectable Melanoma|Metastatic Melanoma
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vericiguat in Patients With Metabolic Syndrome and Coronary Vascular Dysfunction
Status: RECRUITING
Conditions: Metabolic Syndrome|Coronary Microvascular Dysfunction
Interventions: DRUG: Vericiguat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Low Particle Emission and Low Noise Tyres
Status: COMPLETED
Conditions: Noise Exposure|Sleep Disturbance|Sleep Hygiene|Metabolic Disturbance|Cognitive Change
Interventions: RADIATION: Tyre noise - continuous flow|RADIATION: Tyre noise - discrete events|RADIATION: High noise level|RADIATION: Moderate noise level|RADIATION: Low noise level|RADIATION: Air-filled tyres|RADIATION: Composite tyres
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Daily Topical Rapamycin for Vitiligo
Status: ACTIVE_NOT_RECRUITING
Conditions: Vitiligo
Interventions: DRUG: Rapamycin|DRUG: Rapamycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Olanzapine and Mirtazapine in the Improvement of Unintentional Weight Loss for Patients With Advanced Stage Cancer
Status: UNKNOWN
Conditions: Anorexia Nervosa With Significantly Low Body Weight
Interventions: DRUG: Mirtazapine|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Short-Course Glucocorticoids and Rituximab for Treatment of ANCA-Associated Vasculitis
Status: COMPLETED
Conditions: Granulomatosis With Polyangiitis|Microscopic Polyangiitis
Interventions: DRUG: Glucocorticoids|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-world Experience With Lutetium Vipivotide Tetraxetan in Metastatic Castration Resistant Prostate Cancer
Status: NOT_YET_RECRUITING
Conditions: Metastatic Castration Resistant Prostate Cancer
Interventions: OTHER: lutetium (177Lu) vipivotide tetraxetan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Safety and Pharmacokinetics Study of a Recombinant Fusion Protein Linking Coagulation Factor VIIa With Albumin (rVIIa-FP) in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: rVIIa-FP|BIOLOGICAL: Placebo (0.9% normal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open Label Study to Measure Efficacy of Fesoterodine (Toviaz) Post Surgery for Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Bladder Outlet Obstruction
Interventions: DRUG: Toviaz (Fesoterodine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of eHealth Monitoring on Overall Survival in Patients With Metastatic NSCLC / Extensive-stage SCLC / Advanced TNBC Under First-line Treatment With Atezolizumab Plus Chemotherapy
Status: COMPLETED
Conditions: Stage IV Non-small Cell Lung Cancer|Extensive-stage Small Cell Lung Cancer|Advanced (Locally Advanced and Inoperable or Metastatic), PD-L1 IC-positive TNBC
Interventions: OTHER: eHealth system support for symptom management via CANKADO
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparing Two Different Embryo Transfer Catheters
Status: UNKNOWN
Conditions: Infertility
Interventions: DEVICE: Ultrasound guided embryotransfer with Cook K-Jets-551910-S|DEVICE: Ultrasound guided embryotransfer with Cook k-soft-5000 (or K-J-SP-681710 and K-J-SPPE-681710)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label, Bioequivalence Study of Certolizumab Pegol 200 mg Solution Injected Either by a Prefilled Syringe (Reference) or by an E-Device (Test) in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Prefilled syringe (PFS)|DEVICE: e-Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: CARdiAc Mri and BiOLogical samplEs at the Acute Phase of a Myocardial Infarction (CARAMBOLE)
Status: RECRUITING
Conditions: Myocardial Infarction
Interventions: BIOLOGICAL: Blood, urinary and feces collection|DEVICE: Cardiac MRI|OTHER: Quality of life and cognitive status questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Efficacy and Safety Study of a 8 or 12-Week Treatment Regimen of Simeprevir in Combination With Sofosbuvir in Treatment-Naive and Experienced Participants With Chronic Genotype 4 Hepatitis C Virus Infection
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Simeprevir|DRUG: Sofosbuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Waterjet Ablation Therapy for Endoscopic Resection of Prostate Tissue (WATER)
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia (BPH)
Interventions: DEVICE: AQUABEAM System|PROCEDURE: Transurethral Resection of the Prostate (TURP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide and Ipilimumab After Stem Cell Transplant in Treating Patients With Hematologic or Lymphoid Malignancies
Status: COMPLETED
Conditions: B-Cell Non-Hodgkin Lymphoma|Hematopoietic and Lymphoid Cell Neoplasm|Leukemia|Lymphoma|Plasma Cell Myeloma|T-Cell Non-Hodgkin Lymphoma
Interventions: BIOLOGICAL: Ipilimumab|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Sequelae: Treatment and Monitoring. A Dietary Supplement Based on Sea Urchin Eggs With Echinochroma A
Status: COMPLETED
Conditions: Long COVID
Interventions: DIETARY_SUPPLEMENT: Echinochrome A|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modified Thoracoscopic Pleural Cryobiopsy in Diagnosis of Exudative Pleural Effusion
Status: UNKNOWN
Conditions: Pleural Effusion
Interventions: DEVICE: Modified Thoracoscopic pleural Cryobiopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Greater Occipital Nerve (GON) Block Effectivity in the Treatment of Chronic Migraine: 6 Months Follow up
Status: WITHDRAWN
Conditions: Migraine Disorders
Interventions: DRUG: bupivacaine|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Trigger-point Blockade in Persistent Pain After Open Groin Hernia Repair
Status: COMPLETED
Conditions: Inguinal Hernia|Chronic Pain
Interventions: DRUG: Bupivacaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Protective Effect of Mechanism of Pentoxyfilline After Major Liver Resection Under Inflow Occlusion (Pringle Manoeuvre)
Status: COMPLETED
Conditions: Liver Regeneration
Interventions: DRUG: pentoxyfilline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Pre-emptive Scalp Infiltration With Ketorolac and Ropivacaine for Post-craniotomy Pain
Status: UNKNOWN
Conditions: Pain|Supratentorial Brain Tumor
Interventions: DRUG: Ketorolac|DRUG: Ropivacaine|DRUG: Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of a Prebiotic, a Probiotic and a Synbiotic Upon the Gut Microbiota and Immune Response of Healthy Volunteers
Status: COMPLETED
Conditions: Gut Microbiota|Bowel Function|Immune Function|Plasma Lipids
Interventions: DIETARY_SUPPLEMENT: Prebiotic|DIETARY_SUPPLEMENT: Bi-07|DIETARY_SUPPLEMENT: Synbiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness and Acceptability of Stellate Ganglion Block for Posttraumatic Stress Disorder Symptoms - Effectiveness
Status: COMPLETED
Conditions: PostTraumatic Stress Disorder
Interventions: DRUG: Ropivacaine|DRUG: Sham treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pain With Belotero® Balance With Integral Lidocaine for Correction of the Nasolabial Folds
Status: COMPLETED
Conditions: Correction of Moderate to Severe Nasolabial Folds
Interventions: DEVICE: Belotero® Balance with integral lidocaine|DEVICE: Belotero® Balance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Exenatide and Insulin Glargine in Type 2 Diabetes Patients for Whom Insulin is the Next Appropriate Therapy
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: exenatide/insulin glargine|DRUG: insulin glargine/exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Exercise and Social Interaction in a Community-Based Sample of Non-Demented Chinese Elders
Status: COMPLETED
Conditions: Cognitive Impairment|Dementia|Mild Cognitive Impairment|Alzheimer Disease
Interventions: OTHER: Fast walking|OTHER: Tai Chi|OTHER: Intellectual stimulation|OTHER: Contact and testing only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects and Mechanism of Prolonged Continuous Theta Burst Stimulation on Neuropathic Pain
Status: COMPLETED
Conditions: Neuropathic Pain|Repetitive Transcranial Magnetic Stimulation
Interventions: DEVICE: Repetitive transcranial magnetic stimulation|DEVICE: Repetitive transcranial magnetic stimulation|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Insights From the Retina on Cerebral Microvascular Dysfunction in Haemorrhagic Stroke
Status: COMPLETED
Conditions: Intracerebral Hemorrhage
Interventions: DIAGNOSTIC_TEST: OCT and OCTA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of a Package of Evidence-based Interventions and Implementation Strategies Based on WHO PEN for People Living With HIV and Cardio-metabolic Conditions in Lusaka, Zambia
Status: RECRUITING
Conditions: HIV|Non Communicable Diseases
Interventions: OTHER: TASKPEN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Chemoradiation Plus Weekly c225 Against Locoregionally Advanced Nasopharyngeal Carcinoma (NPC)
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma
Interventions: RADIATION: Intensity-modulated radiotherapy|DRUG: Concurrent chemotherapy with paclitaxel and nedaplatin|BIOLOGICAL: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of New Posterior Reconstruction Method on Recovery of Continence After Robot-assisted Laparoscopic Prostatectomy
Status: COMPLETED
Conditions: Localized Prostate Cancer|Urinary Incontinence
Interventions: PROCEDURE: Posterior reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study to Evaluate the Safety and Immunogenicity of Heterologous Boost Immunizations With MVA-CMDR
Status: COMPLETED
Conditions: HIV
Interventions: BIOLOGICAL: MVA-CMDR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Short Contact Protocols to Reduce Pain During 10% ALA Gel Red-light Photodynamic Therapy of Actinic Keratoses
Status: ACTIVE_NOT_RECRUITING
Conditions: Actinic Keratosis
Interventions: DRUG: Topical aminolevulinate (10% ALA gel)|DEVICE: Red light illumination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability Study of Progesterone Vaginal Tablets (Endometrin®) in Menopausal Women Treated by Estrogen
Status: UNKNOWN
Conditions: Endometrial Hyperplasia|Endometrial Cancer
Interventions: DRUG: progesterone|DRUG: activella
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Finding Study of TNO155 in Adult Patients With Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced EGFRmutant NonSmallSellLungCancer (NSCLC),KRAS G12-mutant NSCLC,Esophageal SquamousCellCancer (SCC),Head/Neck SCC,Melanoma
Interventions: DRUG: TNO155|DRUG: TNO155 in combination with EGF816 (nazartinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodal Endoscopic Image Fusion for Assessing Infiltration in Superficial Esophageal Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Esophageal Neoplasms Malignant
Interventions: DIAGNOSTIC_TEST: Magnifying Endoscopy and Endoscopic Ultrasonography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Parent-based Electronic Health (eHealth) Intervention on Preschoolers' Physical Activity, Dietary Behaviors, and Sleep Problems
Status: NOT_YET_RECRUITING
Conditions: Healthy Lifestyle|Physical Activity|Dietary Behaviors|Sleep
Interventions: BEHAVIORAL: parent-based Electronic Health intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Multicentric Evaluation of COVID-19 Impact on Cancer Patients' Diagnostic and Management: Set-up of Indicators
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Peritoneal Carcinoma
Interventions: OTHER: COLLAT-COVID is an observational study based on retrospective data issued from patients medial files.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of OraQuick HCV Rapid Antibody Test and Standard Serologic Screening for Hepatitis C: Validity, Acceptability and Impact on Linkage to Care
Status: TERMINATED
Conditions: Active or Ex-injection Drug Users|Indication of Hepatitis C Screening
Interventions: DEVICE: Oraquick HCV Rapid Antibody Test|DEVICE: Standard algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Transperitoneal vs Retroperitoneal Laparoscopic or Robotic Partial Nephrectomy
Status: UNKNOWN
Conditions: Renal Cell Carcinoma
Interventions: PROCEDURE: Laparoscopic or robotic partial nephrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Osteoporosis in Primary Hyperparathyroidism
Status: ENROLLING_BY_INVITATION
Conditions: Primary Hyperparathyroidism|Osteoporosis
Interventions: DRUG: Denosumab 60 MG/ML Prefilled Syringe [Prolia]|DRUG: Zoledronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect and Tolerability of Lactobacillus Rhamnosus GG LA801 for the Preventive Nutritional Care of Nosocomial Diarrhea in Children
Status: TERMINATED
Conditions: Nosocomial Infection|Diarrhea, Infantile
Interventions: DIETARY_SUPPLEMENT: Babybiane Imedia or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: KN046 in Subjects With Advanced Squamous Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Squamous Non-small-cell Lung Cancer
Interventions: DRUG: KN046|DRUG: KN046 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "Efficacy and Safety of Phlai Capsule Compared to Placebo as the Treatment in Allergic Rhinitis Patients"
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Phlai|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Human Papillomavirus Vaccine Immunogenicity and Safety Trial in Young Adult Women With GSK Biologicals Novel HPV Vaccine
Status: COMPLETED
Conditions: Infections, Papillomavirus|Papillomavirus Vaccines
Interventions: BIOLOGICAL: CervarixTM|BIOLOGICAL: HPV investigational vaccine GSK568893A, different formulations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Longidaza® for the Treatment of Patients With Residual Changes in the Lungs After COVID-19
Status: COMPLETED
Conditions: Post-Acute COVID-19 Syndrome|Lung Disease With Polymyositis|Fibrosis|Lung Diseases, Interstitial|Lung; Disease, Interstitial, With Fibrosis
Interventions: DRUG: Longidaza®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis
Status: UNKNOWN
Conditions: HIV Infections|Tuberculous Meningitis
Interventions: DRUG: Combivir and efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RCT Comparing Methadone and Buprenorphine in Pregnant Women
Status: COMPLETED
Conditions: Opioid Related Disorders|Pregnancy|Opioid Dependence
Interventions: DRUG: Methadone|DRUG: Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementing Injury Prevention Training in Youth Handball (I-PROTECT) Using the RE-AIM Evaluation Framework
Status: ACTIVE_NOT_RECRUITING
Conditions: Athletic Injuries|Health Behavior
Interventions: BEHAVIORAL: I-PROTECT|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Effectiveness of Giving Adefovir Dipivoxil Plus Abacavir Plus Efavirenz Plus Amprenavir to HIV-Infected Patients Who Have Failed to Respond to Previous Protease Inhibitor Treatment
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Abacavir sulfate|DRUG: Amprenavir|DRUG: Efavirenz|DRUG: Adefovir dipivoxil
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy Assessment of Geltim LP® 1 mg/g in Ocular Hypertensive or Glaucomatous Patients.
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: Geltim LP 1 mg/g|DRUG: Xalatan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effectiveness of Imiquimod 5% Cream for Basal Cell Carcinoma Recurrence
Status: COMPLETED
Conditions: Basal Cell Carcinoma
Interventions: DRUG: Imiquimod 5% cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Investigating Safety, Tolerability, Pharmacokinetics (PK) and Antitumor Activities of Anti-PD-1 (Programmed Death-1) Monoclonal Antibody
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quality of Life of Frail Aged Patients in Incremental Hemodialysis
Status: UNKNOWN
Conditions: Renal Dialysis|Kidney Failure, Chronic|Frailty
Interventions: OTHER: Dialysis frequency reduction|OTHER: Frailty diagnosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Atorvastatin Versus Vitamin E in Treatment of Non-alcoholic Fatty Liver Disease
Status: UNKNOWN
Conditions: Fatty Liver|Dyslipidemias|Diabetes Mellitus
Interventions: DRUG: atorvastatin|DRUG: Vitamin E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Deep Retinal Capillary Ischemia by Electromagnetic Stimulation and Platelet- Rich Plasma
Status: COMPLETED
Conditions: Deep Retinal Capillary Ischemia|Paracentral Acute Middle Maculopathy|Acute Macular Neuroretinopathy
Interventions: DEVICE: Electromagnetic stimulation|BIOLOGICAL: Platelet rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid to Reduce Blood Loss in Hemorrhagic Caesarean Delivery
Status: TERMINATED
Conditions: Pregnancy Complications|Hemorrhage
Interventions: DRUG: tranexamic acid 1 g (TA1)|DRUG: tranexamic acid 0.5 g (TA1/2)|DRUG: Saline Solution (TA0)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrating Animal-Assisted Therapy Into Trauma-Focused Cognitive-Behavioral Therapy for Maltreated Youth
Status: COMPLETED
Conditions: Child Abuse|Posttraumatic Stress
Interventions: BEHAVIORAL: TF-CBT|BEHAVIORAL: TF-CBT+AAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Endorphins in the Perception of Dyspnea in Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: naloxone versus placebo|DRUG: intravenous injection of normal saline or naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Ridge Preservation Following Tooth Extraction Using Porcine and Bovine Xenograft Materials
Status: COMPLETED
Conditions: Alveolar Bone Loss
Interventions: DEVICE: Porcine Xenograft (Zcore)|DEVICE: Bovine Xenograft (Bio-Oss)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk-adapted Donor Lymphocyte Infusion After Allo-HSCT in Children With Hematologic Malignancy
Status: COMPLETED
Conditions: Hematologic Malignancy
Interventions: BIOLOGICAL: Prophylactic Donor lymphocytes infusions|BIOLOGICAL: Preventive Donor lymphocytes infusions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Huperzine A Sustained-Release Tablets in Patients With Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer's Disease
Interventions: DRUG: Huperzine A|DRUG: huperzine A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Perampanel for Sporadic Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: ALS
Interventions: DRUG: Perampanel|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sublingual Immunotherapy in Patients With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: BIOLOGICAL: Dermatophagoides Farinae Drops Group 1|BIOLOGICAL: Dermatophagoides Farinae Drops Group 2|BIOLOGICAL: Dermatophagoides Farinae Drops Group 3|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study Of Thymoglobulin In Patients With Relapsed Or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Relapsed Or Refractory Multiple Myeloma
Interventions: DRUG: thymoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Autologous Adipose-derived Mesenchymal Stem Cells Therapy in Adults With Atrophic Scars
Status: RECRUITING
Conditions: Atrophic Scar
Interventions: BIOLOGICAL: TRTP-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of A Single Dose Combination of Methadone and Morphine With Morphine Alone for Treating Post-operative Pain
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Methadone|DRUG: methadone and morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Study for Safety and Efficacy of Two Devices for the Treatment of the Great Saphenous Vein
Status: WITHDRAWN
Conditions: Varicose Veins|Venous Insufficiency
Interventions: DEVICE: VNUS RF ClosureFAST|DEVICE: VenaCure EVLT NeverTouch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment of New Speaking Valve With Heat and Moisture Exchanger (HME) for Tracheotomized Patients
Status: COMPLETED
Conditions: Tracheostomy
Interventions: DEVICE: TW speaking valve/HME
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Esophagus-sparing Radiotherapy for Metastatic Spinal Cord Compression.
Status: RECRUITING
Conditions: Metastatic Spinal Cord Compression|Radiation Toxicity|Esophagitis|Patient Reported Outcome Measures
Interventions: RADIATION: Esophagus sparring radiotherapy treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Mesenchymal Stem Cells in Knee Cartilage Injuries
Status: COMPLETED
Conditions: Articular Cartilage Disorder of Knee|Osteoarthritis, Knee
Interventions: BIOLOGICAL: Autologous Mesenchymal Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Ticagrelor Versus Aspirin Treatment in Patients With Myocardial Injury Post Major Non-cardiac Surgery
Status: TERMINATED
Conditions: Myocardial Injury
Interventions: DRUG: ticagrelor|DRUG: aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Safety and Tolerability of Single Ascending Doses of Rozanolixizumab Administered by Subcutaneous Infusion in Healthy Japanese, Chinese and Caucasian Study Participants
Status: COMPLETED
Conditions: Healthy-volunteers
Interventions: DRUG: Rozanolixizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Doxycycline and Cefuroxime Axetil in Erythema Migrans
Status: COMPLETED
Conditions: Erythema Chronicum Migrans
Interventions: DRUG: doxycycline|DRUG: Cefuroxime Axetil 500Mg Tab|OTHER: control subjects
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Safety and Tolerability of BSCT (Anti-nf-P2X7) 10% Ointment
Status: COMPLETED
Conditions: Carcinoma, Basal Cell (BCC)
Interventions: DRUG: Treatment with BSCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Treating Patients With Small Bowel Adenocarcinoma That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Small Intestinal Adenocarcinoma|Recurrent Small Intestinal Carcinoma|Unresectable Small Intestinal Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT