pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effectiveness of an Immediate Postoperative Intravesical Instillation With Either Gemcitabine or Epirubicin in Patients With Urinary Bladder Cancer (Gemcitabine Epirubicin Normal SAline)
Status: RECRUITING
Conditions: Bladder Cancer
Interventions: DRUG: Gemcitabine Hydrochloride combined with continuous saline irrigation|DRUG: Epirubicin Hydrochloride combined with continuous saline irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Choline Alfoscerate on Improvement of Cognitive Function in Elderly Patients With Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Choline alfoscerate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of CPAP Treatment on Glycemic Control in Gestational Diabetes: A Pilot Randomized-Controlled Trial
Status: COMPLETED
Conditions: Pregnancy|Sleep-disordered Breathing|Gestational Diabetes
Interventions: DEVICE: CPAP|OTHER: Nasal dilator strip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Pentoxifylline Gel on Behcet's Disease Genital Ulcers
Status: NOT_YET_RECRUITING
Conditions: Behcet Syndrome|Behcet Disease
Interventions: DRUG: Topical Pentoxifylline Gel (Vehicle +PTX)|DRUG: Topical Placebo Gel (Vehicle)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multiple-Ascending-Dose Study of the Safety and Tolerability of REGN421(SAR153192) in Patients With Advanced Solid Malignancies
Status: COMPLETED
Conditions: Advanced Solid Malignancies
Interventions: DRUG: REGN421(SAR153192)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S-1 vs Capecitabine in the Elderly and/or Poor Performance Status Patients With Recurrent or Metastatic Gastric Cancer
Status: UNKNOWN
Conditions: Stomach Neoplasms
Interventions: DRUG: S-1, capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Chiropractic Treatment on Infantile Colic A Randomized, Controlled Trial
Status: TERMINATED
Conditions: Infantile Colic
Interventions: PROCEDURE: Chiropractic treatment|PROCEDURE: Visit without active treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Metabolic Effects of Breaks in Sedentary Time
Status: COMPLETED
Conditions: Feasibility|Insulin|Glucose|Lipids|Eating
Interventions: OTHER: Sedentary|OTHER: Sedentary With Breaks|OTHER: Sedentary With Breaks and Physical Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Dupilumab in Children With Uncontrolled Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Dupilumab|DRUG: Placebo|DRUG: Asthma Controller Therapies|DRUG: Asthma Reliever Therapies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preference Methotrexate (MTX) Pre-filled Syringe Versus Pre-filled Pen in Rheumatoid Arthritis (RA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: methotrexate prefilled pen|DRUG: methotrexate prefilled syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validity and Reliability of the 12-item Multiple Sclerosis Walking Scale (12-WS) in Subjects With Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries|Gait Disorders, Neurologic
Interventions: OTHER: 12 MSWS questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Comparison of Meperidine for Post-Cesarean Analgesia: Bolus Versus Infusion and Bolus
Status: COMPLETED
Conditions: Cesarean Section
Interventions: DRUG: Meperidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of General Versus Spinal Anesthesia on Postoperative Myocardial Injury
Status: RECRUITING
Conditions: Myocardial Injury After Non-cardiac Surgery|Hypotension During Surgery|Anesthesia, General|Anesthesia, Spinal
Interventions: PROCEDURE: General Anesthesia|PROCEDURE: Spinal Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Value of add-on Arrhythmia Surgery in Patients With Atrial Fibrillation Undergoing Cardiac Surgery
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: pulmonary vein isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Thoracic Epidural Analgesia in Flail Chest
Status: UNKNOWN
Conditions: Flail Chest
Interventions: DRUG: Morphine Sulfate|DRUG: Triamcinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Autologous, Micro-fragmented Adipose Tissue for Meniscal Tears
Status: COMPLETED
Conditions: Tibial Meniscus Injuries|Osteoarthritis, Knee
Interventions: DEVICE: Lipogems
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-nutrient Supplement to Improve Physical Performance in Older Adults
Status: COMPLETED
Conditions: Old Age
Interventions: DIETARY_SUPPLEMENT: Multi-nutrient supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: COVID-19: Nasal and Salivary Detection of the SARS-CoV-2 Virus After Antiviral Mouthrinses
Status: COMPLETED
Conditions: COVID19|Mouthwash|Saliva
Interventions: DEVICE: mouthrinse with bêta-cyclodextrin and citrox|DEVICE: mouthrinse without bêta-cyclodextrin and citrox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Influence of Hepatic Insufficiency on the Pharmacokinetics of Doravirine (MK-1439) (MK-1439-019)
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: Doravirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Asses the Effect of Dapagliflozin on Central Blood Pressure Reduction.
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Dapagliflozin 10 mg|DRUG: Glimepiride 4 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Preoperative Symbiotic Bowel Conditioning on Surgical Site Infection After Elective Colorectal Surgery
Status: UNKNOWN
Conditions: Postoperative Wound Infection
Interventions: BIOLOGICAL: Symbiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Antineoplaston Therapy in Treating Patients With Brain Stem Glioma
Status: COMPLETED
Conditions: Brain Stem Gliomas
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digital Evaluation of Accuracy for Removable Partial Denture Frameworks
Status: COMPLETED
Conditions: Denture|Partial
Interventions: OTHER: Selective laser melting framework was fabricated using completely digital workflow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Impact of Per Oral Pyloromyotomy (POP) on Glycemic Control in Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus|Gastroparesis With Diabetes Mellitus|Gastroparesis
Interventions: PROCEDURE: Pyloromyotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mechanism of Microbiome-induced Insulin Resistance in Humans (Aim 1)
Status: COMPLETED
Conditions: Insulin Sensitivity
Interventions: DRUG: Sevelamer|DRUG: Synbiotic|DRUG: Maltodextrin|OTHER: High Fat diet|OTHER: Low Fat diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-washing the Catheter With a Culture Medium Before Intrauterine Insemination
Status: UNKNOWN
Conditions: Infertility
Interventions: PROCEDURE: Pre-washed catheter vs. Unwashed catheter in the intrauterine insemination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Therapeutic Exercise and Therapeutic Patient Education With or Without Manual Therapy for Chronic Nonspecific Low Back Pain.
Status: UNKNOWN
Conditions: Chronic Nonspecific Low Back Pain|Low Back Pain
Interventions: PROCEDURE: Manual Therapy, Therapeutic Education, Therapeutic Exercice|PROCEDURE: Therapeutic Education, Therapeutic Exercice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Investigational Immuno-therapy Study to Investigate the Safety and Effectiveness of Nivolumab, and Nivolumab Combination Therapy in Virus-associated Tumors
Status: COMPLETED
Conditions: Various Advanced Cancer
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab|DRUG: Relatlimab|DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of Group A and C Meningococcal Polysaccharide Conjugate Vaccine in Volunteers Aged 3-5 Months
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Population
Interventions: BIOLOGICAL: Group A and C Meningococcal Polysaccharide Conjugate Vaccine (producted by Zhifei Lvzhu)|BIOLOGICAL: Group A and C Meningococcal Polysaccharide Conjugate Vaccine (producted by Walvax)|BIOLOGICAL: Group A and C Meningococcal Polysaccharide Conjugate Vaccine (producted by Olymvax)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: This Study Will Evaluate the Persistence of Hepatitis A Antibodies, 8 Years and 10 Years Later, in Children Who Had Received Havrix at Selected Health Centres of Panama
Status: COMPLETED
Conditions: Hepatitis A Vaccine
Interventions: OTHER: Blood sample collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Functional Inspiratory Muscle Training in Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Diseases
Interventions: OTHER: Functional Inspiratory Muscle Training|OTHER: Inspiratory Muscle Training|OTHER: Breathing exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Photobiomodulation on Pain in Patients With Temporomandibular Dysfunction
Status: NOT_YET_RECRUITING
Conditions: TMJ Pain
Interventions: DEVICE: Photobiomodulation using LED|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Neuromuscular Electrical Stimulation in Older Patients With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: OTHER: Superimposed Neuromuscular Electrical Stimulation|OTHER: Quadriceps Strengthening|BEHAVIORAL: Patient Education Program|OTHER: Aerobic Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety/Tolerability Study With AZD1236 in Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: AZD1236|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II NCT (Neoadjuvant Chemotherapy) w/ Weekly Abraxane in Combination With Carboplatin & Bevacizumab in Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: bevacizumab|DRUG: carboplatin|DRUG: nab-paclitaxel|PROCEDURE: Surgery|DRUG: Adjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Esketamine|DRUG: Placebo|DRUG: Triazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Opioid-Free Anesthesia in TMJ Surgery
Status: RECRUITING
Conditions: Temporomandibular Joint Disorders
Interventions: DRUG: Dexmedetomidine / Ketamine / Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bioactive Composite Versus Resin-Modified Glass Ionomer Liners: 2-Year Clinical Trial
Status: COMPLETED
Conditions: Dental Caries
Interventions: OTHER: ACTIVA bioactive|OTHER: Riva LC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: the Effect of Danhong Injection on Microcirculation in the Treatment of Patients With STEMI After the PTCA Surgery.
Status: UNKNOWN
Conditions: Myocardial Infarction
Interventions: DRUG: Danhong Injection|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Psychoeducation on Hopelessness, Death Anxiety and Caregiver Burden
Status: COMPLETED
Conditions: Support, Family
Interventions: OTHER: Watson Human Caring Model-based psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of HRS-1780 Tablets and Henagliflozin Proline Tablets in Patients With Chronic Kidney Disease
Status: RECRUITING
Conditions: Chronic Kidney Disease
Interventions: DRUG: HRS-1780 tablet；Henagliflozin Proline tablet；HRS-1780 tablet placebo ；Henagliflozin Proline tablet placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sutureless Cryopreserved Amniotic Membrane Graft (ProKera) and Wound Healing After Photorefractive Keratectomy
Status: UNKNOWN
Conditions: Corneal Wound Healing
Interventions: DEVICE: ProKera|DEVICE: Bandage contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Non-preservative-free Morphine With Bupivacaine Versus Intrathecal Bupivacaine Alone for Analgesia in Unilateral Inguinal Hernia Repair Surgeries
Status: RECRUITING
Conditions: Pain, Postoperative
Interventions: DRUG: Morphine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of BIBR 277 Tablet Compared With Capsule in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIBR 277 tablet|DRUG: BIBR 277 capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Clinical Study Assessing the Effects of Tetracycline Antibiotic on Tear Film and Tear Lipid Composition Within a Population of Patients Diagnosed With Blepharitis and Dry Eye Disease
Status: WITHDRAWN
Conditions: Dry Eye Syndrome
Interventions: DRUG: Tetracycline: Doxycycline analog
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Ischaemic Conditioning in STEMI Patients in Sub-Saharan AFRICA
Status: RECRUITING
Conditions: STEMI|Remote Ischaemic Conditioning|Myocardial Reperfusion Injury
Interventions: DEVICE: Remote Ischaemic Conditioning (RIC)|DEVICE: Sham-control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Electrical Nerve Stimulation Improves Vascular Conductance After Coronary Artery Bypass Graft Surgery
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DEVICE: Transcutaneous electrical nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase Ⅱ Study of an All-Oral Combination of Low-dose Etoposide/Capecitabine in Patients With Metastatic Breast Cancer Previously Treated With Anthracyclines and/or Taxanes
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Capecitabine|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Citrasate Dialysate on Heparin Dose in Hemodialysis
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: OTHER: citrate dialysate (CD)|OTHER: acetic-acid based dialysate (AD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Reacquisition of Radioactive Iodine (RAI) Uptake of RAI-Refractory Metastatic Thyroid Cancers by Pretreatment With the Selective MEK Inhibitor AZD6244
Status: COMPLETED
Conditions: Thyroid Cancer
Interventions: BIOLOGICAL: AZD6244
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT of the Effectiveness of Big White Wall Compared to Other Online Support
Status: UNKNOWN
Conditions: Depression|Anxiety
Interventions: OTHER: BWW Online Peer Support|OTHER: NHS Moodzone Online Information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Jewel Electrophysiology (EP) Lab Study
Status: COMPLETED
Conditions: Sudden Cardiac Arrest
Interventions: DEVICE: Jewel Patch Wearable Cardioverter Defibrillator (P-WCD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Training Second-grade Dyslexic Students Using a Computerized Program in Assiut, Egypt
Status: COMPLETED
Conditions: Dyslexia
Interventions: BEHAVIORAL: Computerized Cognitive abilities training battery for reading (CATB-R)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Propranolol (vs. Placebo) on Information Processing During Presentation of Emotionally Arousing Pictures
Status: COMPLETED
Conditions: Emotions
Interventions: DRUG: propranololhydrochloride|DRUG: placebo|DEVICE: Net Station® System and compatible Geodesic Sensor Nets®|DEVICE: VITAPORT|DEVICE: ergoselect II 100/200|DEVICE: SpiroScout|DEVICE: Mobil-O-Graph® PWA|PROCEDURE: Saliva collection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: VNRX-5133 SAD/MAD Safety and PK in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Bacterial Infections
Interventions: DRUG: VNRX-5133|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Aortic Stiffness as a Prognostic Indicator of Aortic Dilatation in Patients With Bicuspid Aortic Valve by Multimodal Imaging
Status: ACTIVE_NOT_RECRUITING
Conditions: Bicuspid Aortic Valve
Interventions: DEVICE: Magnetic Resonance Imaging|DEVICE: Transthoracic echocardiography|DEVICE: Echography UltraFast
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Observational Study of Baska Mask, a New Supraglottic Airway Device
Status: COMPLETED
Conditions: Performance and Safety of a New Supraglottic Airway Device
Interventions: DEVICE: Placement and use of Baska mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrosurgical Modes for Endoscopic Submucosal Dissection in Peroral Endoscopic Esophageal Myotomy
Status: RECRUITING
Conditions: Achalasia|Achalasia Cardia
Interventions: PROCEDURE: endoscopic submucosal dissection using SPRAY COAG mode|PROCEDURE: endoscopic submucosal dissection using Precisect mode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: XRB vs. SLB in Jail and at Re-entry: Pilot, Proof of Concept
Status: COMPLETED
Conditions: Opioid Dependence
Interventions: DRUG: Buprenorphine Extended Release|DRUG: Sublingual Buprenorphine (SUBOXONE, Zubsolv, or generic tablets)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tafenoquine and Primaquine in Colostrum and Breast Milk
Status: WITHDRAWN
Conditions: Healthy Lactating Women
Interventions: DRUG: Primaquine|DRUG: Tafenoquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Hygiene Education, ReadiWatchTM Actigraphy, and Telehealth Cognitive Behavioral Training for Insomnia Effect, on Symptom Relief for Men With Prostate Cancer Receiving Androgen Deprivation Therapy
Status: COMPLETED
Conditions: Prostate Cancer|Sleep Disturbance|Fatigue|Cognitive Impairment
Interventions: BEHAVIORAL: teleCBT-I + SH/ReadiWatchTM|BEHAVIORAL: SH/ReadiWatchTM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of MEDI-573 Plus Standard Endocrine Therapy for Women With Hormone-sensitive Metastatic Breast Cancer
Status: COMPLETED
Conditions: Hormone-sensitive, HER-2 Negative Metastatic Breast Cancer
Interventions: DRUG: MEDI-573|DRUG: Aromatase Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-articular Magnesium Sulfate for Tmj Dysfunction
Status: UNKNOWN
Conditions: Temporomandibular Joint Disorders|Temporomandibular Sprain
Interventions: DRUG: intra-articular injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Correction of Fixed Knee Flexion Deformity in Children Using Eight-plate Hemiepiphysiodesis
Status: COMPLETED
Conditions: Knee Deformity
Interventions: PROCEDURE: Eight plate hemiepiphysiodesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ASP3082 in Adults With Previously Treated Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: ASP3082|DRUG: Cetuximab|DRUG: Chemotherapy 1|DRUG: Chemotherapy 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Questionnaire Content on Measures of Pain Intensity, Magnitude of Disability, and Symptoms of Depression in Patients With Arm Illness
Status: COMPLETED
Conditions: Arm Illness
Interventions: OTHER: PROMIS Upper Extremity Function|OTHER: Pain intensity|OTHER: PROMIS depression|OTHER: Positive affect negative affect scale (PANAS)|OTHER: standard PCS|OTHER: positively-adjusted version of the PCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Clinical Study to Evaluate the Efficacy of the Stand-alone Cervical Interbody Cage C-CURVE ( Titanium) Manufactured by MEDICREA®
Status: ACTIVE_NOT_RECRUITING
Conditions: C-CURVE , Cervical Interbody Cage|Cervical Disc Disease|Cervical Discopathy
Interventions: DEVICE: cervical interbody cage C-CURVE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Photodynamic Therapy in the Disinfection of Root Canals in Patients With Apical Lesion
Status: RECRUITING
Conditions: Endodontic Treatment|Periapical Diseases
Interventions: OTHER: Group 2 PDT (10 s)|OTHER: Group 3 PDT 20 s|OTHER: Group 1. Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of DIM Supplements to Increase 2-OHE1/16 Ratio
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DIETARY_SUPPLEMENT: DIM pills|OTHER: Placebo Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Alpha-lipoic Acid on Regression of Low-grade Squamous Intraepithelial Lesions (LSIL)
Status: COMPLETED
Conditions: Low-Grade Squamous Intraepithelial Lesions
Interventions: DIETARY_SUPPLEMENT: DL-alpha lipoic acid|OTHER: placebo (rice starch)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diffusion Tensor Brain MRI in the Detection of Structural Abnormality of the White Substance in Concussion
Status: RECRUITING
Conditions: Concussion, Brain
Interventions: OTHER: specific MRI Acquisition (Diffusion Tensor Imaging) at 3T
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The ILERVAS Project: Assessing the Prevalence of Subclinical Vascular Disease and Hidden Kidney Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Atherosclerosis|Chronic Kidney Diseases|Metabolic Syndrome|PreDiabetes|Subclinical Disease and/or Syndrome
Interventions: DIAGNOSTIC_TEST: Dried blood spot test|DIAGNOSTIC_TEST: Urine test|DIAGNOSTIC_TEST: Artery ultrasound|DIAGNOSTIC_TEST: Ankle-brachial index|DIAGNOSTIC_TEST: Spirometry|DIAGNOSTIC_TEST: Determination of advanced glycation-end products|DIAGNOSTIC_TEST: Atrial fibrillation screening|OTHER: Biological sample collection|OTHER: Result and recommendation report|DIAGNOSTIC_TEST: Pulse wave velocity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Radiotherapy Versus Low-Dose Tamoxifen Following Breast Conserving Surgery for Low-Risk Breast Ductal Carcinoma in Situ
Status: RECRUITING
Conditions: Breast Ductal Carcinoma in Situ
Interventions: DRUG: Low-dose tamoxifen|RADIATION: Whole breast radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Sintilimab Plus Capecitabine in Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Sintilimab|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Agili-C™ Implant Performance Evaluation
Status: ACTIVE_NOT_RECRUITING
Conditions: Cartilage or Osteochondral Defects in the Knee|Up to Moderate Osteoarthritis
Interventions: DEVICE: Agili-C implant|PROCEDURE: SSOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Oligonucleotide Chip Analysis for Allergic Rhinitis Treatment in Herbal Plaster and Acupuncture
Status: COMPLETED
Conditions: Rhinitis, Allergic
Interventions: DRUG: Herbal plaster (Sanfujiu)|PROCEDURE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Evaluation of the Effect of 'Open Window' on Psychological Well-being and Experience of Stem Cell Transplantation
Status: COMPLETED
Conditions: Hematological Malignancies
Interventions: BEHAVIORAL: 'Open Window' Project
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bio-enhanced Curcumin as an Add-on Treatment in Maintaining Remission of Ulcerative Colitis
Status: UNKNOWN
Conditions: Ulcerative Colitis
Interventions: DIETARY_SUPPLEMENT: Bio-enhanced Curcumin Soft Gelatin Capsule|DRUG: 5-Aminosalicyclic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cobalamin Status in Young Children With Gastrointestinal Symptoms or Feeding Problems
Status: COMPLETED
Conditions: Vitamin B 12 Deficiency
Interventions: DIETARY_SUPPLEMENT: Hydroxycobalamin (Vitamin B12 Depot, Nycomed Pharma)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Utility of Amyl Nitrite in Patients With Suspected Achalasia Undergoing High Resolution Esophageal Manometry (HREM)
Status: WITHDRAWN
Conditions: Dysphagia|Achalasia
Interventions: DRUG: Amyl Nitrite
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: [18F]FPIA PET-CT in Glioblastoma Multiforme (GBM)
Status: RECRUITING
Conditions: Glioblastoma Multiforme of Brain
Interventions: DIAGNOSTIC_TEST: Positron Emission Tomography-Computerised Tomography (PET-CT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Treatment Study for Premenstrual Syndrome (PMS)
Status: COMPLETED
Conditions: Premenstrual Syndrome|Menstruation Disturbances
Interventions: DRUG: Leuprolide|DRUG: Estradiol Patches|DRUG: Progesterone|DRUG: Placebo patch|DRUG: Placebo injection|DRUG: Placebo suppository
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety and Efficacy of CSL312 (Garadacimab) in the Prophylactic Treatment of Hereditary Angioedema Attacks
Status: ACTIVE_NOT_RECRUITING
Conditions: Hereditary Angioedema
Interventions: BIOLOGICAL: CSL312
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Immunogenicity, Safety and Reactogenicity of GSK Biologicals' Boostrix Vaccine Administered as a Booster Dose in Healthy Russian Subjects
Status: COMPLETED
Conditions: Diphtheria-Tetanus-acellular Pertussis Vaccines
Interventions: BIOLOGICAL: Boostrix
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Radiation Therapy Combined With Chemotherapy in Treating Patients With Anaplastic Astrocytoma or Mixed Gliomas
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: BCNU 80mg/m2|DRUG: TMZ 200mg/m2|RADIATION: radiation therapy|DRUG: CCNU|DRUG: BCNU 150mg/m2|DRUG: BCNU 200mg/m2|DRUG: TMZ 150mg/m2 six 6-week cycles|DRUG: TMZ 150mg/m2 six 8-week cycles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Sevoflurane and Midazolam Used for the Maintenance of Anaesthesia on the Levels of Postoperative Cardiac Troponin I in Pediatric Cardiac Surgery
Status: UNKNOWN
Conditions: Myocardial Injury|Anaesthetic Preconditioning
Interventions: DRUG: Midazolam|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of Creon IR in Subjects With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis
Status: COMPLETED
Conditions: Exocrine Pancreatic Insufficiency in Subjects With Cystic Fibrosis
Interventions: DRUG: Creon IR|DRUG: Creon® (DR/GR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Virological and Clinical Anti-Hepatitis B Virus (HBV) Efficacy of Tenofovir and Emtricitabine in Patients With HIV/HBV co-Infection
Status: COMPLETED
Conditions: HIV Infections|Hepatitis B
Interventions: DRUG: tenofovir|DRUG: emtricitabine|DRUG: zidovudine|DRUG: efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Rosuvastatin Plus Ezetimibe Versus High-dose Rosuvastatin in AMI
Status: UNKNOWN
Conditions: Myocardial Infarction|Statin Adverse Reaction|HMG-CoA Reductase Inhibitor Toxicity
Interventions: DRUG: Ezetimibe 10mg + Rosuvastatin 5mg|DRUG: Rosuvastatin 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CAR T-cell Therapy in Patients With Renal Dysfunction
Status: NOT_YET_RECRUITING
Conditions: Non-hodgkin Lymphoma,B Cell|Multiple Myeloma|Acute Lymphoblastic Leukemia, Adult
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COmparing arNi and Ace For Improving Erectile Dysfunction in mEN With reduCed Ejection Fraction Heart Failure
Status: COMPLETED
Conditions: Heart Failure|Heart Failure, Systolic|Erectile Dysfunction
Interventions: DRUG: LCZ696|DRUG: Enalapril matching placebo|DRUG: Enalapril|DRUG: LCZ696 matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Functional Exercise Tests in Patients With Systemic Sclerosis
Status: UNKNOWN
Conditions: Scleroderma, Systemic|Lung Diseases, Interstitial|Pulmonary Arterial Hypertension|Acroosteolysis
Interventions: DIAGNOSTIC_TEST: 6-minute walk test part one|DIAGNOSTIC_TEST: 6-minute walk test part two|DIAGNOSTIC_TEST: 1-minute sit-to-stand test|DIAGNOSTIC_TEST: 4-meters gait speed test|DIAGNOSTIC_TEST: Nailfold videocapillaroscopy|DIAGNOSTIC_TEST: HR-pQCT|DIAGNOSTIC_TEST: Hand x-ray|DIAGNOSTIC_TEST: DEXA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Weaning Using Noninvasive Positive Pressure Ventilation by Means of Helmet in Patients With Acute Respiratory Failure
Status: COMPLETED
Conditions: Inadequate or Impaired Breathing Pattern or Ventilation
Interventions: DEVICE: Helmet|DEVICE: Endotracheal tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Abnormally Fertilized Zygotes? InVitro Correction of 3PN
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: Correction of abnormally fertilized oocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sporadic Angiomyolipomas (AMLs) Growth Kinetics While on Everolimus
Status: TERMINATED
Conditions: Sporadic Angiomyolipomas (AMLs)
Interventions: DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Preoperative Long-Term Immunonutrition in Patients Listed for Liver Transplantation
Status: UNKNOWN
Conditions: Newly Registered Patients for Primary Liver Transplantation
Interventions: DIETARY_SUPPLEMENT: Immunonutrition|DIETARY_SUPPLEMENT: food for special medical purposes (FSMP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Pilates Method in the Range of Ballerina's Turnout
Status: COMPLETED
Conditions: Dancing
Interventions: OTHER: Pilates Mat Classes|OTHER: Ballet Classes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hoosier Sport: Developing and Implementing a Sustainable Campus-Community Partnership in Rural Indiana
Status: COMPLETED
Conditions: Cardiovascular Diseases|Sedentary Behavior
Interventions: BEHAVIORAL: Hoosier Sport
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Guadecitabine (SGI-110) vs Treatment Choice in Adults With MDS or CMML Previously Treated With HMAs
Status: COMPLETED
Conditions: Myelodysplastic Syndromes|Leukemia, Myelomonocytic, Chronic
Interventions: DRUG: Guadecitabine|OTHER: Treatment Choice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label Phase 2 Study of Avutometinib (RAF/MEK Clamp) in Combination With Defactinib (FAK Inhibitor) and Cetuximab in Patients With Unresectable, Anti-EGFR-Refractory Advanced Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Advanced Colorectal Cancer
Interventions: DRUG: Defactinib|DRUG: Cetuximab|DRUG: Avutometinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: INNOVATIVE TREATMENT OF SCARRED VOCAL FOLDS BY LOCAL INJECTION OF AUTOLOGOUS ADIPOSE-DERIVED STROMAL VASCULAR FRACTION: EFFICACY VERSUS PLACEBO
Status: RECRUITING
Conditions: Scarred Vocal Folds
Interventions: DRUG: AUTOLOGOUS ADIPOSE-DERIVED STROMAL VASCULAR FRACTION|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a New Formulation of DTPa-HBV-IPV/Hib Vaccine Administered as a Booster Dose to 18-23 Months Old Children
Status: COMPLETED
Conditions: Poliomyelitis|Acellular Pertussis|Tetanus|Diphtheria|Hepatitis B
Interventions: BIOLOGICAL: Infanrix™ penta|BIOLOGICAL: Infanrix™ hexa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of a Low-cost CPAP Device on Hospitalized COVID-19 Patients
Status: COMPLETED
Conditions: Covid19|Hypoxemia
Interventions: DEVICE: High Flow Nasal Oxygen (HFNO) treatment|DEVICE: Continuous Positive Airway Pressure (CPAP) therapy using OxyJet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Therapist Behavior on the Treatment of Depressed Adolescents
Status: COMPLETED
Conditions: Depression|Depressive Disorder|Dysthymic Disorder
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mitomycin C Intravesical Chemotherapy in Conjunction With Synergo® Radiofrequency-Induced Hyperthermia for Treatment of Carcinoma in Situ Non-Muscle Invasive Bladder Cancer Patients Unresponsive to Bacillus Calmette-Guérin, With or Without Papillary Tumors.
Status: TERMINATED
Conditions: Bladder Cancer|Bladder Neoplasm|Bladder Tumors|Cancer of Bladder|Cancer of the Bladder|Malignant Tumor of Urinary Bladder|Neoplasms, Bladder|Urinary Bladder Cancer|Carcinoma in Situ of Bladder|Papillary Carcinoma of Bladder (Diagnosis)|BCG-Unresponsive Bladder Cancer
Interventions: COMBINATION_PRODUCT: Synergo® RITE + MMC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Weight Bearing After Intramedullary Fixation Devices for the Proximal Femur Fracture
Status: UNKNOWN
Conditions: Closed Comminuted Oblique Intertrochanteric Fracture of Neck of Right Femur|Closed Comminuted Oblique Intertrochanteric Fracture of Neck of Left Femur
Interventions: DEVICE: PFNA proximal femur nail device (Synthes)|DEVICE: INTERTAN proximal femur nail device (Smith&Nephew)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of HLX208 in Metastatic Colorectal Cancer (mCRC) With BRAF V600E Mutation
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Colorectal Cancer|mCRC
Interventions: DRUG: HLX208
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Investigating the Effect of Omalizumab (Xolair) in Work-Related Animal Induced Asthma
Status: WITHDRAWN
Conditions: Allergy Induced Asthma
Interventions: DRUG: omalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Injectable Platelet Rich Fibrin Augmented With Vitamin C Compared to Injectable Platelet Rich Fibrin Alone on Healing of Necrotic Mature Single Rooted Teeth With Chronic Peri-apical Periodontitis Following Regenerative Endodontics (A Randomized Controlled Trial)
Status: NOT_YET_RECRUITING
Conditions: Periapical Periodontitis
Interventions: OTHER: injectable platelet rich fibrin augmented with Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of the Antidiabetic Drug Dapagliflozin on the Coronary Macrovascular and Microvascular Function in Type 2 Diabetic Patients
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Dapagliflozin 10 mg Tab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Sarcoidosis Randomized Trial
Status: RECRUITING
Conditions: Cardiac Sarcoidosis|Sarcoidosis
Interventions: DRUG: Prednisone or Prednisolone|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Effectiveness and Safety of Radiesse (+) to Improve the Contour of Jawline by Adding Volume to the Jawline
Status: COMPLETED
Conditions: Improvement of Jawline Contour
Interventions: DEVICE: Radiesse (+)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Boron Neutron Capture Therapy Using Boronophenylalanine-Fructose Complex in Treating Patients With Metastatic Melanoma
Status: TERMINATED
Conditions: Melanoma (Skin)
Interventions: DRUG: boronophenylalanine-fructose complex
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Adults Investigating Eptinezumab Produced by 2 Different Manufacturing Cell Lines
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Eptinezumab Mammalian Cell Line|DRUG: Eptinezumab Yeast Cell Line
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Niraparib Before Surgery in Treating Patients With High Risk Localized Prostate Cancer and DNA Damage Response Defects
Status: RECRUITING
Conditions: ATM Gene Mutation|BRCA1 Gene Mutation|BRCA2 Gene Mutation|BRIP1 Gene Mutation|CDK12 Gene Mutation|CHEK1 Gene Mutation|CHEK2 Gene Mutation|DNA Damage Response Gene Mutation|DNA Repair Gene Mutation|FANCA Gene Mutation|FANCD2 Gene Mutation|FANCL Gene Mutation|GEN1 Gene Mutation|NBN Gene Mutation|Prostate Carcinoma|RAD51 Gene Mutation|RAD51C Gene Mutation
Interventions: DRUG: Niraparib|DRUG: Niraparib Tosylate Monohydrate|PROCEDURE: Radical Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT