pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pain Treatment After TKA With LIA and Intra-articular Continuous Infusion Pump
Status: COMPLETED
Conditions: Postoperative Pain Management
Interventions: DRUG: Ropivacaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Serotonin Agonist Buspirone on Multimodal Esophageal Stimulation in Healthy Volunteers
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DRUG: Buspirone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: A Prospective Evaluation of Infraorbital Filler Injection
Status: ACTIVE_NOT_RECRUITING
Conditions: Dermal Filler|Rejuvenation
Interventions: PROCEDURE: Juvederm Volbella XC hyaluronic acid dermal filler injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Aerobic Exercise Training on Cardiorespiratory Fitness in Stroke Patients
Status: COMPLETED
Conditions: Stroke, Cardiovascular
Interventions: OTHER: The Effects of Aerobic Exercise Training on Cardiorespiratory Fitness, Functional Capacity, Balance and Ventricular Repolarization Indices in Stroke Patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of JAB-3312 in Adult Patients With Advanced Solid Tumors in China
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer|Colorectal Cancer|Pancreatic Ductal Carcinoma|Esophageal Squamous Cell Carcinoma|Head and Neck Squamous Cell Carcinoma|Breast Cancer|Other Solid Tumors
Interventions: DRUG: JAB-3312
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Cardiotoxicity by Cardiac Magnetic Resonance (CMR) in Breast Cancer Patients Receiving Trastuzumab
Status: UNKNOWN
Conditions: Stage I-IV Breast Cancer (Neo-adjuvant, Adjuvant, Locally Advanced and Metastatic)
Interventions: PROCEDURE: Cardiac MRI|BIOLOGICAL: Biomarker Testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hand MOtor Rehabilitation Using a EMG-biofeedback: a Cross-sectional Study
Status: COMPLETED
Conditions: Stroke|Stroke Hemorrhagic|Stroke, Ischemic|Hemiparesis|Hemiplegia
Interventions: DEVICE: EMG-biofeedback armband (REMO)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: TherVacB - A Heterologous Protein Prime/MVA Boost Therapeutic Hepatitis B Vaccine Candidate
Status: NOT_YET_RECRUITING
Conditions: Chronic Hepatitis B
Interventions: BIOLOGICAL: TherVacB (HEPLISAV B)|BIOLOGICAL: TherVacB (HBsAg ± c-di-AMP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Foot-Ankle Exercise and Walking Exercise on Diabetes Mellitus Patients
Status: NOT_YET_RECRUITING
Conditions: Diabetic Foot|Diabetes Mellitus, Type 2|Diabetic Neuropathies|Diabetes Type 2|Diabetes|Diabetes Mellitus|Diabetes Complications
Interventions: OTHER: Foot-ankle exercise|OTHER: Walking exercise|OTHER: Usual care and health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Most Effective Stimulation Site in Transcranial Direct Current Stimulation for Gait Recovery After Stoke
Status: COMPLETED
Conditions: Stroke|Gait Disorders, Neurologic
Interventions: DEVICE: Ipsilesional stimulation|DEVICE: Contralesional stimulation|OTHER: Walking on treadmill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physiotherapeutic Case Studies in Frozen Shoulder Pathology
Status: COMPLETED
Conditions: Articular; Rigid
Interventions: DIAGNOSTIC_TEST: First data analysis|PROCEDURE: Second data analysis|OTHER: database
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erlotinib and Standard Platinum-Based Chemotherapy for Newly Diagnosed, Advanced Non-Small Cell Carcinoma of the Lung
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Erlotinib|DRUG: Platinum-based chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FrexalimAB in Preservation of Endogenous insULIN Secretion Compared to Placebo in adUlts and Adolescents on Top of inSulin Therapy (FABULINUS)
Status: RECRUITING
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Frexalimab|DRUG: Placebo|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating Efficacy and Safety of Two Degarelix Three-Month Dosing Regimens in Patients With Prostate Cancer Requiring Androgen Ablation Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Degarelix|DRUG: Degarelix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-oxidative Metabolite Profiles After Increasing Doses of Ethanol
Status: COMPLETED
Conditions: Alcohol Consumption|Healthy
Interventions: DIETARY_SUPPLEMENT: 10 g ethanol|DIETARY_SUPPLEMENT: 20 g ethanol|DIETARY_SUPPLEMENT: 40 g ethanol|DIETARY_SUPPLEMENT: 60 g ethanol|DIETARY_SUPPLEMENT: 80 g ethanol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Does Rectus Re-approximation Cause Adhesion After Cesarean Section?
Status: UNKNOWN
Conditions: Obstetric Complication|Muscle Injury
Interventions: PROCEDURE: Rectus muscle re-approximation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity of Freeze-dried Rabies Vaccine（MRC-5 Cell) in Chinese Humans
Status: COMPLETED
Conditions: Safety, Immunogenicity
Interventions: BIOLOGICAL: 2.5IU/ml rabies vaccine(MRC-5 cell) in humans aged 10-20 years old|BIOLOGICAL: 2.5IU/ml rabies vaccine(MRC-5 cell) in humans aged 21-50 years old|BIOLOGICAL: 2.5IU/ml rabies vaccine(MRC-5 cell) in humans aged 51-60 years old|BIOLOGICAL: 2.5IU/ml rabies vaccine(vero cell) in humans aged 10-20 years old|BIOLOGICAL: 2.5IU/ml rabies vaccine(vero cell) in humans aged 21-50 years old|BIOLOGICAL: 2.5IU/ml rabies vaccine(vero cell) in humans aged 51-60 years old
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of Recombinant Human Arginase 1 in Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: PEG-BCT-100
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Botanical Microglia Modulators in Gulf War Illness
Status: COMPLETED
Conditions: Gulf War Illness
Interventions: DIETARY_SUPPLEMENT: Boswellia Serrata|DIETARY_SUPPLEMENT: Curcumin|DIETARY_SUPPLEMENT: Epimedium|DIETARY_SUPPLEMENT: Fisetin|DIETARY_SUPPLEMENT: Luteolin|DIETARY_SUPPLEMENT: Nettle|DIETARY_SUPPLEMENT: Pycnogenol|DIETARY_SUPPLEMENT: Reishi Mushroom|DIETARY_SUPPLEMENT: Resveratrol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Feasibility and Acceptability of Use of Daily Oral Rinse in Pregnant Women in Rural Nepal
Status: COMPLETED
Conditions: Periodontitis|Premature Birth of Newborn
Interventions: DRUG: Chlorhexidine|DRUG: Cetylpyridinium chloride|DRUG: Salt and Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Astaxanthin on Oxidative Stress Indices in Patients With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: PCOS
Interventions: DIETARY_SUPPLEMENT: Astaxanthin 8 mg|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Treatment of Periappendicular Abscess After the Acute Phase
Status: ACTIVE_NOT_RECRUITING
Conditions: Periappendicular Abscess
Interventions: PROCEDURE: Interval appendectomy|PROCEDURE: Follow-up with MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Neuro-cognitive and Psychosocial Intervention Module in People With Epilepsy
Status: RECRUITING
Conditions: Drug Resistant Epilepsy
Interventions: BEHAVIORAL: Neurocognitive and psychosocial intervention module
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A IMMA Master Protocol: A Study of LY3361237 in Participants With at Least Moderately Active Systemic Lupus Erythematosus
Status: TERMINATED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: LY3361237|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Pulsed Electromagnetic Field And Progressive Resistance Exercise On Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: COMBINATION_PRODUCT: Pulsed electromagnetic field and Progressives resistance exercise|OTHER: PRE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lumbar Intervertebral Disc Herniation
Status: UNKNOWN
Conditions: Lumbar Disc Herniation
Interventions: DEVICE: Dynamic Stabilization|PROCEDURE: Discectomy|DEVICE: Instrumentation and fusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Discriminant Ability of the Shock Index, Modified Shock Index, and Reverse Shock Index Multiplied by the Glasgow Coma Scale on Mortality in Adult Trauma Patients: A PATOS Study
Status: COMPLETED
Conditions: Trauma|Shock, Traumatic|Morality
Interventions: OTHER: Observational
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Influence of Methotrexate on the Metabolism and Vascular Effects of Adenosine in Humans
Status: COMPLETED
Conditions: Methotrexate|Vasodilation
Interventions: DRUG: Methotrexate 15 mg/week for 12 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacoeconomic Study Comparing the Use of Mycophenolate Mofetil or Cyclophosphamide as Induction Therapy in Lupus Nephritis Patients in Egypt
Status: COMPLETED
Conditions: Lupus Nephritis
Interventions: DRUG: endoxan|DRUG: cellcept
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Actively Warm Trauma Patients-2
Status: NOT_YET_RECRUITING
Conditions: Trauma Injury|Hypothermia|Massive Hemorrhage
Interventions: OTHER: Ready-Heat Chemical Heating Blankets|OTHER: Warmed blankets or FAWB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy Study of Pembrolizumab (MK-3475) Combined With Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Advance Melanoma (MK-7902-003/E7080-G000-312/LEAP-003)
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Melanoma
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Lenvatinib|DRUG: Placebo for lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intraoperative Tramadol on Postoperative Opioid
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Pethidine|DRUG: Tramadol with pethidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Psychological Support for Intensive Care Nurses During the COVID-19 Pandemic: The PROACTIVE Feasibility Trial
Status: RECRUITING
Conditions: Psychological|Burnout|Post Traumatic Stress Disorder|Anxiety|Depression
Interventions: BEHAVIORAL: Guided imagery and FLASH technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Ixabepilone/Carboplatin/Trastuzumab in HER2-Positive Locally Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Ixabepilone|DRUG: Trastuzumab|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Food on the Bioavailability of a Capsid Inhibitor (CAI) in Male and Female Healthy Participants
Status: RECRUITING
Conditions: HIV Infections
Interventions: DRUG: VH4011499
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: iCBT for Long-term Conditions in IAPT
Status: TERMINATED
Conditions: Diabetes|Chronic Pain|COPD|CHD - Coronary Heart Disease|Depression|Anxiety
Interventions: BEHAVIORAL: Space in Diabetes|BEHAVIORAL: Space in COPD|BEHAVIORAL: Space in Chronic Pain
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Purified Vero Rabies Vaccine Compared With Two Reference Rabies Vaccines, Given in a Pre-exposure Regimen to Children and Adults and as Single Booster Dose to a Subset of Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Rabies (Healthy Volunteers)
Interventions: BIOLOGICAL: Purified vero rabies vaccine - serum free - VRVg-2|BIOLOGICAL: Purified inactivated rabies vaccine - Verorab®|BIOLOGICAL: Purified inactivated rabies vaccine - Imovax® Rabies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Niraparib in Patients With Ovarian Cancer Who Have Received Three or Four Previous Chemotherapy Regimens
Status: COMPLETED
Conditions: Ovarian Neoplasms|Ovarian Cancer
Interventions: DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-Human Clinical Trial of a Mosaic Quadrivalent Influenza Vaccine Compared With a Licensed Inactivated Seasonal QIV, in Healthy Adults
Status: COMPLETED
Conditions: Influenza|Seasonal Influenza
Interventions: OTHER: VRC-GENADJ0110-AP-NV|BIOLOGICAL: Flucelvax|DRUG: VRC-FLUMOS0111-00-VP (FluMos-v1)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Coronary and Heart Effects of Early Treatment in Familial Hypercholesterolemia
Status: COMPLETED
Conditions: Familial Hypercholesterolemia
Interventions: DIAGNOSTIC_TEST: Coronary computed tomography angiography (CCTA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Vaccine Therapy and Celecoxib in Treating Patients With Metastatic Nasopharyngeal Cancer
Status: UNKNOWN
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: Ad5F35-LMP1/LMP2-transduced autologous dendritic cells|DRUG: celecoxib|OTHER: flow cytometry|OTHER: immunoenzyme technique|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Efficacy of Using Insulin-like Growth Factor-1 in Patients With a Heart Attack
Status: COMPLETED
Conditions: Heart Failure|Myocardial Infarction
Interventions: DRUG: mecasermin|DRUG: mecasermin|DRUG: 0.9% sodium chloride injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Will Decreased Noradrenergic Activity Normalize Information Processing in Patients With Schizophrenia?
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: clonidine|DRUG: clonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Accuracy of 18F-rhPSMA-7.3 PET/ MRI for Prediction of Lymph Node Metastasis in Localized High-Risk Prostate Cancer
Status: RECRUITING
Conditions: Localized Prostate Carcinoma|Oligometastatic Prostate Carcinoma|Stage I Prostate Cancer AJCC v8|Stage II Prostate Cancer AJCC v8|Stage III Prostate Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8
Interventions: PROCEDURE: Bilateral Pelvic Lymph Node Dissection|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|OTHER: Electronic Health Record Review|OTHER: Flotufolastat F-18 Gallium|PROCEDURE: Laparoscopic Radical Prostatectomy with Robotics|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: The Study of the Prevalence Fibromuscular Dysplasia in Patient With Haematoma or Spontaneous Coronary Artery Dissection.
Status: COMPLETED
Conditions: Spontaneous Coronary Artery Dissection|Spontaneous Coronary Artery Haematoma
Interventions: PROCEDURE: blood sample for genetic analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Molar Intrusion Using High Pull Headgear
Status: COMPLETED
Conditions: Anterior Openbite
Interventions: DEVICE: high pull headgear + OBA|DEVICE: OBA (control group)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaginal Indomethacin for Preterm Labor
Status: NOT_YET_RECRUITING
Conditions: Obstetric Labor, Premature
Interventions: DRUG: Indomethacin|DRUG: Nifedipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Filler Agent Composed of Autologous Mesenchymal Stem Cells and Hyaluronic Acid
Status: UNKNOWN
Conditions: Lipodystrophies|Aesthetics Procedure
Interventions: PROCEDURE: Adipose tissue collection|BIOLOGICAL: Transdermal injection|PROCEDURE: Transdermal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intensive Crisis Intervention
Status: ENROLLING_BY_INVITATION
Conditions: Suicide|Suicidal Ideation|Suicide, Attempted|Suicide and Self-harm|Suicide Threat
Interventions: BEHAVIORAL: Intensive Crisis Intervention (ICI)|BEHAVIORAL: Adolescent Psychiatric Inpatient Unit (APIU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Intravenous Tranexamic Acid in Reducing Blood Loss During and After Cesarean Section
Status: UNKNOWN
Conditions: Bleeding
Interventions: DRUG: Tranexamic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Stem Cell Therapy Combined With NeuroRegen Scaffold™ in Patients With Erectile Dysfunction After Rectal Cancer Surgery
Status: UNKNOWN
Conditions: Rectal Cancer|Erectile Dysfunction
Interventions: PROCEDURE: Laparoscopic surgery|DEVICE: NeuroRegen scaffold transplantation|BIOLOGICAL: NeuroRegen scaffold/BMMCs transplantation|BIOLOGICAL: NeuroRegen scaffold/HUC-MSCs transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CD34 Selection Using the Automated CliniMACS Prodigy
Status: NOT_YET_RECRUITING
Conditions: AML|ALL|Lymphoid Malignancies|Myelodysplastic Syndromes|CML|Primary Myelofibrosis
Interventions: DRUG: Infusion of CD34 selected hematopoietic stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Session Pain Psychology Treatment: Comparative Efficacy & Mechanisms
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: BEHAVIORAL: "Empowered Relief" (ER)|BEHAVIORAL: Cognitive Behavioral Therapy (CBT)|BEHAVIORAL: Health Education (HE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Evaluating a Perioperative E-follow-up Protocol in Patients With Ambulatory Surgery for Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: Dedicated and coordinated e-follow-up.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Ziptight or Tricortical Screw Fixation of Acute Tibiofibular Syndesmotic Injury
Status: COMPLETED
Conditions: Ankle Fractures
Interventions: DEVICE: ZipTight suture endobutton|DEVICE: Tricortical 3.5 mm syndesmotic screw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Musical Improvisation Training on Cognitive Function in Older Adults
Status: COMPLETED
Conditions: Aging|Cognitive Aging|Cognitive Impairment|Cognitive Training|Cognitively Normal Older Adults|Mild Cognitive Impairment
Interventions: BEHAVIORAL: Piano Improvisation|BEHAVIORAL: Music Listening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ION464 Administered to Adults With Multiple System Atrophy (HORIZON)
Status: RECRUITING
Conditions: Multiple System Atrophy
Interventions: DRUG: ION464|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label, Drug-Drug Interaction (DDI) Study of Dupilumab (REGN668/SAR231893) in Patients With Moderate to Severe Atopic Dermatitis (AD)
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Dupilumab|DRUG: Midazolam|DRUG: Omeprazole|DRUG: Warfarin|DRUG: Caffeine|DRUG: Metoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Balloon Kyphoplasty and Vertebroplasty in Subacute Osteoporotic Vertebral Fractures
Status: COMPLETED
Conditions: Osteoporotic Vertebral Fracture|Between T5 and L5|Chronic Arthritis, Longer Than Six Weeks Duration
Interventions: DEVICE: balloon kyphoplasty|PROCEDURE: vertebroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Claudin18.2-redirected Chimeric Antigen Receptor T Cells With Co-expression of Cytokines in Solid Tumors
Status: RECRUITING
Conditions: Gastric Adenocarcinoma|Pancreatic Cancer|Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: CT048 Autologous Injection (CT048)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CODY: A Study Evaluating The Safety And Efficacy Of QTORIN 3.9% Sirolimus Topical Gel For The Prevention Of Basal Cell Carcinomas (BCCs) In Patients With Gorlin Syndrome
Status: COMPLETED
Conditions: BCCs in Gorlin Syndrome Patients
Interventions: DRUG: PTX-022|DRUG: Vehicle comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety And Pharmacology Of SNX-5422 Mesylate In Subjects With Refractory Hematological Malignancies
Status: COMPLETED
Conditions: Hematologic Neoplasms
Interventions: DRUG: SNX-5422
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Relative Bioavailability of PA32540 (Asa/Omeprazole), Its Aspirin Component, and Ecotrin® in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PA32540|DRUG: aspirin component of PA32540|DRUG: Ecotrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Comparison of PolarX and the Arctic Front Cryoballoons for PVI in Patients With Symptomatic Paroxysmal AF
Status: ACTIVE_NOT_RECRUITING
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: PVI using the Arctic Front Cryoballoon (Medtronic)|DRUG: PVI using the PolarX Cryoballoon (Boston Scientific)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Probiotics on Symptoms of Depression
Status: TERMINATED
Conditions: Depression|Anxiety
Interventions: DRUG: Probio'Stick|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implantation of a Pudendal PNA Test Lead for Neuromodulation by the ENTRAMI Technique in Case of Chronic Perineal Pain Syndrome.
Status: COMPLETED
Conditions: Pudendal Impingement Syndrome
Interventions: DEVICE: pudendal PNE test lead
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Camrelizumab Combined With Apatinib in the Treatment of Patients With Advanced Gastric Cancer and Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer Recurrent
Interventions: DRUG: Camrelizumab|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-Hypnosis for the Enhanced Recovery After Surgery in Patients With Gynecologic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Female Reproductive System Neoplasm|Recurrent Malignant Female Reproductive System Neoplasm|Metastatic Cervical Cancer
Interventions: OTHER: Best Practice|PROCEDURE: Hypnotherapy|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Prophylactic Octreotide to Prevent or Reduce the Frequency and Severity of Diarrhoea in Subjects Receiving Lapatinib With Capecitabine for the Treatment of Metastatic Breast Cancer
Status: TERMINATED
Conditions: Cancer
Interventions: DRUG: Lapatinib|DRUG: Capecitabine|DRUG: Octreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Stroke Prophylaxis of Acute Atrial Fibrillation With an Electronic Clinical Decision Support Tool
Status: ENROLLING_BY_INVITATION
Conditions: Atrial Fibrillation
Interventions: OTHER: Clinical Decision Support (CDS) tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Use of AC5® Advanced Wound System in the Treatment of Diabetic Foot Ulcers
Status: RECRUITING
Conditions: Non-healing Wound|Diabetic Foot Ulcer
Interventions: DEVICE: AC5® Advanced Wound System|DEVICE: Fibracol Plus Collagen Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Pharmacokinetics and Efficacy of APG-5918 in Healthy Subjects or Anemic Patients
Status: RECRUITING
Conditions: Anemia
Interventions: DRUG: APG-5918|DRUG: Placebo|DRUG: APG-5918|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Renal Impairment on the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Ertugliflozin in Participants With Type 2 Diabetes Mellitus (MK-8835-009)
Status: COMPLETED
Conditions: Renal Impairment|Type 2 Diabetes Mellitus
Interventions: DRUG: Ertugliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Analgesic Efficacy of Modified TAPA and QL Blocks in Laparoscopic Cholecystectomies
Status: COMPLETED
Conditions: Postoperative Pain Management|Postoperative Pain|Analgesia|Nerve Blocks|Cholecystectomy
Interventions: PROCEDURE: anterior Quadratus lumborum block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chidamide Combined With Linperlisibon for the Treatment of Refractory/Relapsed Follicular Lymphoma
Status: RECRUITING
Conditions: Follicular Lymphoma|Refractory B-Cell Lymphoma|Relapsed Non-Hodgkin Lymphoma
Interventions: DRUG: Chidamide combined with Linperlisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Per-oral Endoscopy Pyloromyotomy (G-POEM) in the Treatment of Refractory Diabetic Gastroparesis : Prospective Evaluation of Efficacy
Status: UNKNOWN
Conditions: Gastroparesis
Interventions: PROCEDURE: Per-oral endoscopy pyloromyotomy|PROCEDURE: Intrapyloric injection of Botulinum toxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Hierarchy of Afferents in Postural Control of Children With Dyslexia
Status: COMPLETED
Conditions: Dyslexia
Interventions: OTHER: Posturographic tests|OTHER: Questionnaire of motion sickness susceptibility
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy Study of the PTMA Device to Reduce Mitral Valve Regurgitation in Patients With Heart Failure
Status: SUSPENDED
Conditions: Mitral Regurgitation|Heart Failure
Interventions: DEVICE: Percutaneous transvenous mitral annuloplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Suprascapular Nerve Block in Patients Rehabilitated After Arthroscopic Rotator Cuff Repair
Status: RECRUITING
Conditions: Rotator Cuff Tears|Pain|Nerve Block
Interventions: PROCEDURE: conventional physiotherapy program.|PROCEDURE: Suprascapular nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise and Post-dry Needling Soreness
Status: COMPLETED
Conditions: Shoulder Pain
Interventions: OTHER: Eccentric Exercise|OTHER: Detuned Ultrasound|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Esmya Versus Surgery Before IVF/ICSI
Status: ACTIVE_NOT_RECRUITING
Conditions: Fibroid; Uterus Tumor, Complicating Pregnancy|Infertility, Female|Surgical Procedure, Unspecified
Interventions: DRUG: Ulipristal Acetate 5 MG Oral Tablet
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Physical Activity Behavior Change for Older Adults After Dysvascular Amputation
Status: COMPLETED
Conditions: Amputation|Diabetes Mellitus, Type 2|Peripheral Artery Disease
Interventions: BEHAVIORAL: Physical Activity Behavior Change (PABC)|BEHAVIORAL: Physical Activity Behavior Change (PABC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Concomitant Chemoradiotherapy With Weekly Paclitaxel and Vinorelbine and Granulocyte Colony Stimulating Factor (GCSF) Support in Patients With Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Paclitaxel|DRUG: Vinorelbine|DRUG: Filgrastim|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Symbiont-Restore Study
Status: RECRUITING
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Probiotic capsule (L. reuteri PB-W1™), Placebo sachet|DIETARY_SUPPLEMENT: Prebiotic sachet (Prebiotic Blend), Placebo capsule|COMBINATION_PRODUCT: Probiotic capsule (L. reuteri PB-W1™), Prebiotic sachet (Prebiotic Blend)|DIETARY_SUPPLEMENT: Placebo sachet, Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endotracheal Intubation Using Bonfils Fibrescope Without Neuromuscular Blockade
Status: COMPLETED
Conditions: Endotracheal Intubation|Hemodynamics|Neuromuscular Blockade
Interventions: DEVICE: Bonfils|DEVICE: Macintosh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Trial Comparing Dose-dense AC-T With TP as Adjuvant Therapy for TNBC With Homologous Recombination Repair Deficiency
Status: RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nonsurgical Management of Cesarean Scar Niche Related Abnormal Uterine Bleeding
Status: COMPLETED
Conditions: Intermenstrual Bleeding
Interventions: DRUG: Tranexamic acid, Oral contraceptive pills and the Levonorgestrel-releasing intrauterine system.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ-64530440 in Healthy Japanese Male Participants
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: JNJ-0440|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Phase 2 Feasibility Study of BPX-04 Topical Minocycline Gel in Rosacea
Status: COMPLETED
Conditions: Moderate to Severe Papulopustular Rosacea
Interventions: DRUG: BPX-04 1% minocycline topical gel|DRUG: BPX-04 2% minocycline topical gel|DRUG: BPX-04 vehicle topical gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Esophagectomy in Treating Patients With High-Grade Dysplasia of the Esophagus or Stage I, Stage II, or Stage III Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: PROCEDURE: Minimally invasive esophagectomy (MIE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in People With Schistosomiasis
Status: WITHDRAWN
Conditions: Schistosomiasis
Interventions: DRUG: Praziquantel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Differences in Rate of Decline in CT-defined Skeletal Muscle Mass and Physical Performance in Patients With Advanced Non-small Cell Lung Cancer Receiving Chemotherapy and Targeted Therapy/Immunotherapy, Before and After Treatment.
Status: RECRUITING
Conditions: Advanced Lung Cancer|Sarcopenia
Interventions: DRUG: Chemotherapy drug|DRUG: Targeted Agent|DRUG: Immunotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Glargine to Degludec Insulin Transition With or Without a Bridging Glargine Dose
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Insulin Degludec|DRUG: Insulin Glargine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapy of Chronic Lymphocytic Leukemia With Dasatinib (BMS-354825)
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: DRUG: Dasatinib (BMS-354825)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of GSK2586881 on Acute Hypoxia and Exercise
Status: TERMINATED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: GSK2586881|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endovascular Treatment of Wide Neck Saccular Cerebral Aneurysms
Status: RECRUITING
Conditions: Wide Neck Saccular Cerebral Aneurysms
Interventions: PROCEDURE: Endovascular procedure of treatment of wide neck saccular cerebral aneurysm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Oxygen Therapy Attenuates Central Sensitization Induced by a Thermal Injury in Human Volunteers (HBO)
Status: COMPLETED
Conditions: Pain|Inflammation|Hyperalgesia
Interventions: DRUG: Hyperbaric Oxygen|OTHER: Normal ambient conditions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Active Surveillance Post-Approval Atudy of the Stelkast Surpass Acetabular System
Status: TERMINATED
Conditions: Survivorship and Long-term Safety and Effectiveness of the Stelkast Surpass Acetabular System
Interventions: DEVICE: Stelkast Surpass Acetabular System implant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open Study of CEP-701 in Patients With Refractory Acute Myeloid Leukemia With FLT-3 Mutation
Status: COMPLETED
Conditions: Leukemia, Myeloid
Interventions: DRUG: CEP-701 60mg|DRUG: Cep-701 80mg|DRUG: Cep-701 40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sitravatinib Plus Pembrolizumab in Patients With Advanced Treatment-Naïve PD-L1+ Non-Squamous NSCLC
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung|Lung Diseases|Lung Neoplasms|Metastatic Lung Non-Small Cell Carcinoma|Stage IV Lung Non-Small Cell Cancer AJCC v7|PD-L1 Gene Mutation|Advanced Treatment-Naïve PD-L1|Sitravatinib|Pembrolizumab
Interventions: DRUG: Sitravatinib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KLOS Study - Korean Medicine Registry for Low Back Pain Patients, a Prospective, Observational, Multicenter, Pilot Study
Status: COMPLETED
Conditions: Low Back Pain|Back Pain|Pain|Neurologic Manifestations|Nervous System Diseases
Interventions: OTHER: expose to any drugs or procedures based on traditional Korean medicine theory
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Gastro-intestinal and Hormonal Responses to Systemic Inflammatory Disease
Status: COMPLETED
Conditions: Motility Disorder|Catabolic State|Endotoxemia
Interventions: DIETARY_SUPPLEMENT: Whey|DIETARY_SUPPLEMENT: 3-OHB/whey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pomalidomide With Melphalan and Dexamethasone for Untreated Systemic AL Amyloidosis
Status: TERMINATED
Conditions: Myeloma
Interventions: DRUG: Pomalidomide|DRUG: Melphalan|DRUG: Dexamethasone|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration Using a 22 vs 25-Gauge Needle
Status: COMPLETED
Conditions: Malignant Neoplasm of Respiratory and Intrathoracic Organ Carcinoma|Lung Cancer
Interventions: DEVICE: 25-Gauge Needle|DEVICE: 22-Gauge Needle|PROCEDURE: Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: An Innovative Supportive Care Model for Dementia and Traumatic Brain Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Dementia, Mixed|Dementia Mild|Dementia Moderate|Traumatic Brain Injury|Alzheimer Disease
Interventions: BEHAVIORAL: Telehealth-delivered Care Coordination Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tanespimycin in Treating Patients With Stage III-IV Melanoma
Status: TERMINATED
Conditions: Recurrent Melanoma|Stage III Melanoma|Stage IV Melanoma
Interventions: DRUG: tanespimycin|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Investigate the Safety, Tolerability, and Pharmacokinetics of DWP09031
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: DWP09031|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Safety of Intravenous Tranexamic Acid in Patients Undergoing Supratentorial Meningiomas Resection
Status: ACTIVE_NOT_RECRUITING
Conditions: Seizures|Meningioma
Interventions: DRUG: Tranexamic acid|DRUG: 0.9% saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Cilostazol in the Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler
Status: COMPLETED
Conditions: Cerebral Infarction
Interventions: DRUG: Aspirin|DRUG: cilostazol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Palliative Primary Tumor Resection in Minimally Symptomatic Patients With Colorectal Cancer and Synchronous Unresectable Metastases
Status: UNKNOWN
Conditions: Colorectal Neoplasms|Intestinal Neoplasms|Gastrointestinal Neoplasms|Digestive System Neoplasms|Neoplasms by Site|Neoplasms|Neoplasms, Second Primary|Neoplasm Metastasis|Digestive System Diseases|Gastrointestinal Diseases|Colonic Disease|Intestinal Diseases|Rectal Diseases
Interventions: PROCEDURE: surgery of the primary tumour|DRUG: chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ketotifen/Naphazoline Ophthalmic Solution in the Conjunctival Allergen Challenge Model of Allergic Conjunctivitis.
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: Ketotifen/naphazoline|DRUG: Ketotifen|DRUG: Naphazoline|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of T4K Versus Twin Block in Developing Class II Division I Malocculsion
Status: COMPLETED
Conditions: Orthodontic Appliances
Interventions: DEVICE: T4k Appliance|DEVICE: Twin block appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of an Inactivated Influenza Vaccine (Split Virus, Vero Cell Derived)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Inactivated seasonal influenza vaccine (split virus, vero cell derived)|BIOLOGICAL: Inactivated seasonal influenza vaccine (split virus, egg derived) [licensed control vaccine]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: Dose-ranging Study of Once-daily Regimen of BAY 59-7939 in the Prevention of VTE in Patients Undergoing Elective Total Hip Replacement
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)|DRUG: Rivaroxaban (Xarelto, BAY59-7939)|DRUG: Rivaroxaban (Xarelto, BAY59-7939)|DRUG: Rivaroxaban (Xarelto, BAY59-7939)|DRUG: Rivaroxaban (Xarelto, BAY59-7939)|DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION