pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Evaluate LTI-03 in Newly Diagnosed Idiopathic Pulmonary Fibrosis (IPF) Patients
Status: RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: LTI-03|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Preliminary Efficacy and Safety of INNO-206 Compared to Doxorubicin in Advanced Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Metastatic Soft Tissue Sarcoma|Locally Advanced Soft Tissue Sarcoma|Unresectable Soft Tissue Sarcoma
Interventions: DRUG: INNO-206|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Steroid and Anticoagulant Therapy in covid19
Status: COMPLETED
Conditions: Pneumonia, Viral
Interventions: PROCEDURE: steroid and anticoagulants according to different protocols.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Therapy Using Porfimer Sodium in Treating Patients With Recurrent Mouth or Throat Dysplasia or Recurrent In Situ Cancer or Stage I Cancer of the Mouth or Throat
Status: TERMINATED
Conditions: Head and Neck Cancer
Interventions: DRUG: porfimer sodium|DRUG: Photdynamic Therapy (PDT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Active Vitamin D And Reduced Dose Prednisolone for Treatment in Minimal Change Nephropathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Minimal Change Disease|Nephrotic Syndrome
Interventions: DRUG: Prednisolone|DRUG: Alfacalcidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improvement of Medical Quality and Outcomes Through Intelligent Management and Decision System of Cerebrovascular Diseases Based on Hospital Information System
Status: NOT_YET_RECRUITING
Conditions: Cerebrovascular Disease
Interventions: BEHAVIORAL: Clinical decision support system.|BEHAVIORAL: no intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Hepatitis B Antigen Kidney Graft Into Protective Level Hepatitis B Antibody Recipients
Status: UNKNOWN
Conditions: HBsAg(+) Donor Kidney Allograft|HBsAg(-) Donor Kidney Allograft
Interventions: BIOLOGICAL: HBsAg positive kidney allograft donor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: NANT 2015-02: A Phase 1 Study of Lorlatinib (PF-06463922)
Status: ACTIVE_NOT_RECRUITING
Conditions: Neuroblastoma
Interventions: DRUG: Lorlatinib|DRUG: Cyclophosphamide|DRUG: Topotecan|DRUG: Filgrastim/pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Postprandial Glycaemia by a New Developed Closed-loop Control System - Closedloop4meals
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DEVICE: Closed-loop insulin infusion system|OTHER: Open-loop insulin infusion system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of JAB-21822 in Patients With KRAS p.G12C Mutated Pancreatic Cancer
Status: RECRUITING
Conditions: KRAS P.G12C|Pancreatic Cancer
Interventions: DRUG: JAB-21822
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Effectiveness of a Probiotic Bacterium to Boost the Immune Response to Influenza Vaccines
Status: UNKNOWN
Conditions: Influenza
Interventions: BIOLOGICAL: Fluvax|DRUG: PCC® (Lactobacillus fermentum VRI 003)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of MT-1303 in Subjects With Moderate to Severe Active Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: MT-1303|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Advancing VR-based Attentional Bias As a Biomarker for Tobacco Use Disorder
Status: NOT_YET_RECRUITING
Conditions: Nicotine Addiction|Craving
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Epirubicin and Vinorelbine in Treating Patients With Stage II, Stage III, or Stage IV Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: epirubicin|DRUG: vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maca in Healthy Subjects After Strenuous Endurance Exercise
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: maca|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: UFUR Plus Thalidomide for Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Thalidomide|DRUG: Tegafur/Uracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simvastatin for mTBI
Status: COMPLETED
Conditions: TBI-Traumatic Brain Injury
Interventions: DRUG: simvastatin|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I Trial of PACE for Metastatic Prostate Cancer
Status: WITHDRAWN
Conditions: Metastatic Prostate Cancer
Interventions: DRUG: PACE with Cabazitaxel (15 mg/m2)|DRUG: PACE with Cabazitaxel (20 mg/m2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Placebo-controlled Phase 2 Trial to Investigate the Safety and Efficacy of Secukinumab in Giant Cell Arteritis
Status: COMPLETED
Conditions: Giant Cell Arteritis
Interventions: DRUG: Secukinumab 300 mg, s.c.|DRUG: Prednisolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Physical Activity in Overweight Girls: Implications for Reversing Risk Factors for Type 2 Diabetes
Status: COMPLETED
Conditions: Abdominal Obesity|Physical Activity
Interventions: OTHER: Control|OTHER: Resistance Exercise|OTHER: Aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD19-Specific T Cells Post AlloSCT
Status: TERMINATED
Conditions: B Acute Lymphoblastic Leukemia With t(v;11q23.3); KMT2A Rearranged|Recurrent B Acute Lymphoblastic Leukemia|Recurrent Chronic Lymphocytic Leukemia|Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified|Recurrent Mantle Cell Lymphoma|Recurrent Non-Hodgkin Lymphoma|Recurrent Ph-Like Acute Lymphoblastic Leukemia|Recurrent Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma|Recurrent Small Lymphocytic Lymphoma|Refractory B Acute Lymphoblastic Leukemia|Refractory Chronic Lymphocytic Leukemia|Refractory Diffuse Large B-Cell Lymphoma, Not Otherwise Specified|Refractory Mantle Cell Lymphoma|Refractory Non-Hodgkin Lymphoma|Refractory Ph-Like Acute Lymphoblastic Leukemia|Refractory Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma|Refractory Small Lymphocytic Lymphoma
Interventions: BIOLOGICAL: Autologous CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T Cells|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of Non-Invasive ICP Monitoring in Patients Undergoing Invasive ICP Monitoring Via an Intraparenchymal Pressure Monitoring Device
Status: SUSPENDED
Conditions: Intracranial Hypertension|Brain Injuries|Stroke|Hydrocephalus|Brain Neoplasms
Interventions: DEVICE: HS-1000
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: EUS Guided Portal-systemic Pressure Gradient Measurement to Predict Treatment Response and Outcomes of Varices to Endoscopic Variceal Ligation in Patients With Chronic Hepatitis.
Status: RECRUITING
Conditions: Cirrhosis Portal
Interventions: DEVICE: EUS guided portal pressure gradient measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Single Versus Repeated Piezocision-assisted Orthodontic Tooth Movement
Status: COMPLETED
Conditions: Orthodontic Tooth Movement|Canine Retraction
Interventions: PROCEDURE: Single Piezocision|PROCEDURE: Repeated Piezocision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of QLS31905 and/or QL1706 Combination With Chemotherapy in the Advanced Malignant Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: QLS31905|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: QL1706|DRUG: Chemotherapy drug
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Glycerol Phenylbutyrate & Sodium Phenylbutyrate in Phenylbutyrate Naïve Patients With Urea Cycle Disorders (UCDs)
Status: COMPLETED
Conditions: Urea Cycle Disorder
Interventions: DRUG: RAVICTI|DRUG: NaPBA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Patients With Human Immunodeficiency Virus (HIV)-Related Chronic Diarrhea With Saccharomyces Boulardii or Placebo: A Double Blind Trial
Status: COMPLETED
Conditions: Diarrhea|HIV Infections
Interventions: DRUG: Saccharomyces boulardii
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Immunogenicity and Efficacy Study of PvRII/Matrix-M in Healthy Thai Adults Living in Thailand ( MIST3 )
Status: NOT_YET_RECRUITING
Conditions: Plasmodium Vivax Infection|Malaria Vaccine
Interventions: BIOLOGICAL: Malaria Vaccine|BIOLOGICAL: HBV vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the KIO-201 (Ocular Bandage Gel) for Improving Persistent Corneal Epithelial Defects
Status: COMPLETED
Conditions: Persistent Corneal Epithelial Defect
Interventions: DRUG: KIO-201, a Crosslinked Thiolated Carboxymethyl Hyaluronic Acid 0.75% (CMHA-S)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Progesterone for Maintenance Tocolysis: A Randomized Placebo Controlled Trial
Status: TERMINATED
Conditions: Pregnancy Complications
Interventions: DRUG: Progesterone|DRUG: Polyethylene glycol&hydrogenated vegetable oil.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inulin in Burn-induced Insulin Resistance
Status: NOT_YET_RECRUITING
Conditions: Burn Injury|Insulin Resistance|Post Burn Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: Inulin 20 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of the Youth Readiness Intervention
Status: COMPLETED
Conditions: Anxiety Disorder/Anxiety State|Depressive Disorder/Psychology|Social Problems/Psychology|Stress, Psychological|Violence, Non-accidental
Interventions: BEHAVIORAL: YRI|OTHER: EducAid educational programming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Therapeutic Use of Oral Sodium Phosphate (Z-521) in Primary Hypophosphatemic Rickets
Status: COMPLETED
Conditions: Primary Hypophosphatemic Rickets
Interventions: DRUG: Z-521
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Differences in Brain Network Mechanisms Between STN and GPi Deep Brain Stimulation in the Treatment of Craniocervical Dystonia
Status: RECRUITING
Conditions: Dystonia
Interventions: DEVICE: deep brain stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improved Gut Health Outcomes Associated With Probiotics Fortified With Hydrolyzed Whey Protein in Infant Formula
Status: RECRUITING
Conditions: Gut Health|Gastrointestinal Diseases
Interventions: DIETARY_SUPPLEMENT: Feihe Investigational Formula|DIETARY_SUPPLEMENT: Control Formula|OTHER: Breastfeeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial
Status: RECRUITING
Conditions: Extensive Stage Lung Small Cell Carcinoma
Interventions: DRUG: Atezolizumab|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Periodontal Care and Glycemic Control in Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus|Poor Glycemic Control|Peridontal Disease
Interventions: DRUG: Doxycycline HCI 10mg po for 2 weeks|PROCEDURE: Ultrasonic scaling with 0.12% chlorhexidine gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of Readmission Reduction Interventions for Individuals With Sepsis or Pneumonia
Status: RECRUITING
Conditions: Sepsis|Pneumonia|Lower Resp Tract Infection|Covid19
Interventions: BEHAVIORAL: Structured Telephone Support (STS)|BEHAVIORAL: Low-intensity Remote Patient Monitoring (RPM-Low)|BEHAVIORAL: High-intensity Remote Patient Monitoring (RPM-High)|BEHAVIORAL: Standard Response Team|BEHAVIORAL: Enhanced Response Team
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Rosuvastatin on Carotid Artery Plaques in Patients With Inflammatory Joint Disease
Status: COMPLETED
Conditions: Carotid Artery Plaque|Ankylosing Spondylitis|Rheumatoid Arthritis
Interventions: DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Standard Versus Double Dose Dolutegravir in Patients With HIV-associated Tuberculosis
Status: COMPLETED
Conditions: HIV Infections|Tuberculosis
Interventions: OTHER: Placebo|DRUG: Dolutegravir 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotics on Periodontitis Stage III Grade C Molar-incisor Pattern
Status: COMPLETED
Conditions: Periodontal Diseases
Interventions: DRUG: Probiotic Formula|DRUG: placebo formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Influence of Perioperative Administration of Dexmedetomidine on Inflammation Response and Postoperative Outcomes in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Cytoreductive Surgery; Double Blind Randomized Controlled Trial
Status: COMPLETED
Conditions: Colon Cancer
Interventions: DRUG: dexmedetomidine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioequivalence Study of Terbinafine Hydrochloride Tablets, 250 mg of Dr. Reddy's Under Fasting Conditions
Status: COMPLETED
Conditions: Fasting
Interventions: DRUG: Terbinafine Hydrochloride Tablets, 250 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Awake Nasal Intubation in Laryngopharyngeal Tumors
Status: COMPLETED
Conditions: Airway Management
Interventions: DEVICE: fiberoptic naso-tracheal intubation|DRUG: Topical anaesthesia|DRUG: Light sedation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peptide Vaccine Targeting to Cancer Specific Antigen Combined With Anti-angiogenic Peptide Antigen in Treating Patients With Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: HLA-A*2402restricted URLC10, CDCA1, VEGFR1 and VEGFR2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cancer Vaccine Study for Unresectable Stage III Non-small Cell Lung Cancer (START)
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: Tecemotide (L-BLP25)|DRUG: Single low dose cyclophosphamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mitral Valve Regurgitation Quantification From 3D Color Doppler Ultrasound - Standard of Care Data Collection
Status: COMPLETED
Conditions: Mitral Valve Regurgitation of Any Grade
Interventions: DIAGNOSTIC_TEST: TransEsophageal Echocardiography and TransEsophageal Echocardiography|DIAGNOSTIC_TEST: Cardiac Magnetics Resonance|DIAGNOSTIC_TEST: MitraClip
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: AASUR in High Risk Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: ARN-509|DRUG: Abiraterone|DRUG: Leuprolide|RADIATION: stereotactic, ultra-fractionated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Beta Blocker Dosage in Women While Using the Wearable Cardioverter Defibrillator
Status: RECRUITING
Conditions: Cardiomyopathies|Heart Failure
Interventions: DEVICE: Heart Rate Monitor Enhanced Treatment Optimization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Therapy for Patients With Vascular Occlusive Diseases Such as Diabetic Foot
Status: UNKNOWN
Conditions: Diabetic Foot|Lower Limb Ischemia
Interventions: BIOLOGICAL: Mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare the Effect of Aliskiren Plus Valsartan Versus Angiotensin-Converting Enzyme Inhibitor (ACEi) Plus Angiotensin Receptor Blocker (ARB) [Ramipril Plus Telmisartan] on the Renin-Angiotensin-Aldosterone System (RAAS) in Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Aliskiren/ Valsartan|DRUG: Telmisartan/ Ramipril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Compare Artificial Intelligence Software Aided Adenoma Detection in Screening Colonoscopies Versus Standard Colonoscopy Without Artificial Intelligence Software Assistance in Participants Between 45 and 75 Years of Age
Status: UNKNOWN
Conditions: Colorectal Adenoma|Colorectal Polyp|Colorectal Adenocarcinoma|Colorectal SSA
Interventions: DEVICE: Ultivision Artificial Intelligence Software|DEVICE: No Artificial Intelligence Software enhancement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Objective Measurement With TCM Pattern for AIDDES
Status: RECRUITING
Conditions: Sjögren's Syndrome|Systemic Lupus Erythematosus|Dry Eye Syndrome
Interventions: DIAGNOSTIC_TEST: Traditional Chinese Medicine pattern|DIAGNOSTIC_TEST: Traditional Chinese Medicine tongue diagnosis|DIAGNOSTIC_TEST: Heart rate variability|DIAGNOSTIC_TEST: Schirmer's test|DIAGNOSTIC_TEST: Ocular Surface Diseast Index (OSDI)|DIAGNOSTIC_TEST: EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI)|DIAGNOSTIC_TEST: 36-Item Short Form Survey (SF-36)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Evaluating Effect of Esomeprazole, Omeprazole or Lansoprazole on the Pharmacodynamics (PD) and Pharmacokinetics (PK) of Clopidogrel
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: lansoprazole|DRUG: omeprazole|DRUG: esomeprazole|DRUG: clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety Study of Reslizumab to Treat Poorly Controlled Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: BIOLOGICAL: Reslizumab|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Avastin / Irinotecan in Patients With Recurrent or Progressive Malignant Glioma
Status: UNKNOWN
Conditions: Recurrent Malignant Glioma
Interventions: DRUG: Bevacizumab / Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dose-finding Study of SPK-8016 Gene Therapy in Patients With Hemophilia A to Support Evaluation in Individuals With FVIII Inhibitors
Status: COMPLETED
Conditions: Adeno-Associated Virus (AAV)|Blood Coagulation Disorder|Blood Coagulation Disorders, Inherited|Coagulation Protein Disorders|Factor VIII (FVIII)|Factor VIII (FVIII) Deficiency|Factor VIII (FVIII) Gene|Factor VIII (FVIII) Protein|Genetic Diseases, Inborn|Genetic Diseases, X-Linked|Gene Therapy|Gene Transfer|Hematologic Diseases|Hemorrhagic Disorders|Recombinant|Vector|Inhibitors
Interventions: GENETIC: SPK-8016
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of DZD9008 Versus Platinum-Based Doublet Chemotherapy in Local Advanced or Metastatic Non-small Cell Lung Cancer (WU-KONG28)
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: DZD9008|DRUG: Pemetrexed+carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Speckle Tracking Echocardiography Analysis of Left Ventricular Myocardium After Percutaneous Intramyocardial Septal Radiofrequency Ablation for Hypertrophic Obstructive Cardiomyopathy
Status: COMPLETED
Conditions: Hypertrophic Obstructive Cardiomyopathy
Interventions: PROCEDURE: Percutaneous Intramyocardial Septal Radiofrequency Ablation for hypertrophic obstructive cardiomyopathy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Tailored Communication Intervention Aimed at Increasing the Number of Daily Steps
Status: RECRUITING
Conditions: Physical Inactivity
Interventions: BEHAVIORAL: Walk behavior change: Tailored messages (TM)|BEHAVIORAL: Walk behavior change: Non tailored messages (NTM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Lenalidomide Combined With Dexamethasone in Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Status: TERMINATED
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: CC-5013 (lenalidomide)|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TCR-Redirected T Cell Treatment in Patients With Recurrent HBV-related Hepatocellular Carcinoma Post Liver Transplantation
Status: UNKNOWN
Conditions: Recurrent Hepatocellular Carcinoma
Interventions: BIOLOGICAL: TCR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adapting Connect-Home Transitional Care for the Unique Needs of Persons With Alzheimer's Disease and Other Dementias and Their Caregivers
Status: COMPLETED
Conditions: Pathologic Processes
Interventions: BEHAVIORAL: Connect-Home Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase Ia Clinical Trial to Assess the Safety and Immunogenicity of New Plasmodium Falciparum Malaria Vaccine Candidates ChAd63 RH5 Alone and With MVA RH5
Status: COMPLETED
Conditions: Malaria|Plasmodium Falciparum
Interventions: BIOLOGICAL: ChAd63 RH5 low dose|BIOLOGICAL: ChAd63 RH5 full dose|BIOLOGICAL: MVA RH5 low dose|BIOLOGICAL: MVA RH5 full dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase I/II Study of hLL1-DOX in Relapsed NHL and CLL
Status: TERMINATED
Conditions: Non-Hodgkin's Lymphoma|Chronic Lymphocytic Leukemia
Interventions: DRUG: hLL1-DOX (IMMU-115)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subcutaneous Peripheral Nerve Stimulation (PNS) as "Hybrid Stimulation" After Failure of Spinal Cord Stimulation (SCS) to Control the Back Pain Component in Failed Back Surgery Syndrome (FBSS) Patients.(CUMPNS Study)
Status: COMPLETED
Conditions: Failed Back Surgery Syndrome
Interventions: DEVICE: Subcutaneous peripheral nerve stimulation|OTHER: SCS Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sensing Contact Lens-based Device for 24-hour Monitoring of Intraocular Pressure
Status: COMPLETED
Conditions: Glaucoma, Open-Angle|Healthy
Interventions: DEVICE: Goldfish|DEVICE: Tonometry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effects of Heart Imaging Radiation on DNA Double-Stranded Breaks in Blood Lymphocytes and Hair Follicle Cells
Status: COMPLETED
Conditions: Coronary Artery Disease|Chest Pain
Interventions: RADIATION: CCTA ~ BREAST SHIELDS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Yellow Fever Vaccine in Patients With Rheumatic Diseases
Status: COMPLETED
Conditions: Systemic Lupus|Rheumatoid Arthritis|Spondyloarthritis|Inflammatory Myopathy|Systemic Sclerosis|Mixed Connective Tissue Disease|Takayasu Arteritis|Granulomatosis With Polyangiitis|Sjogren's Syndrome|Juvenile Idiopathic Arthritis|Juvenile Dermatomyositis
Interventions: BIOLOGICAL: Yellow Fever vaccine (17D)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Maintenance Therapy of Levonorgestrel-releasing Intrauterine System (LNG-IUS) to Prevent the Recurrence of Symptomatic Endometriosis After Conservative Surgery
Status: UNKNOWN
Conditions: Endometriosis
Interventions: DEVICE: LNG-IUS|DRUG: GnRH agonist (triptorelin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 1b Study of MEDI4920 in Participants With Adult-onset Rheumatoid Arthritis
Status: COMPLETED
Conditions: Adult Onset Rheumatoid Arthritis
Interventions: DRUG: VIB4920|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Interventions for Alcohol Use Disorder
Status: COMPLETED
Conditions: Alcoholism
Interventions: BEHAVIORAL: Motivational Enhancement Therapy|BEHAVIORAL: Cognitive Behavioral Therapy|OTHER: FC Assessment|OTHER: IB Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Pyrotinib in Combination With Letrozole in Patients With HER2-Positive, ER-Positive Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Pyrotinib Maleate plus Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CERTICOEUR: A Secondary Prevention Study of Skin Cancers in Heart Transplant Patients. Everolimus Versus Calcineurin Inhibitors Multicenter Trial
Status: UNKNOWN
Conditions: Cardiac Transplantation|Skin Cancer
Interventions: DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate Safety of the ExAblate 2100 UF V2 System in the Treatment of Symptomatic Uterine Fibroids
Status: COMPLETED
Conditions: Uterine Fibroids|Bleeding|Pain
Interventions: DEVICE: Exablate 2100
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Efficacy of LIPO-202 for the Reduction of Central Abdominal Bulging Due to Subcutaneous Fat (AbCONTOUR2)
Status: COMPLETED
Conditions: Central Abdominal Bulging
Interventions: DRUG: LIPO-202|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The CPAP Effect in Severe Obstructive- Sleep- Apnea Patients Without Daytime Sleepiness: A Control Randomized Trial
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DEVICE: CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of MBP-426 (Liposomal Oxaliplatin Suspension for Injection) to Treat Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: MBP-426
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability Study in Healthy Subjects to Evaluate the Pharmacokinetics of HTL0009936 After One Dose of Prototype Formulation
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: HTL0009936 modified release|DRUG: HTL0009936 immediate release
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pediatric Remote Ischemic Pre-conditioning Prior to Complex Cardiac Surgery
Status: COMPLETED
Conditions: Congenital Heart Disease|Ischemia-reperfusion Injury
Interventions: OTHER: Remote ischemic pre-conditioning stimulus.|OTHER: Sham Ischemic Pre-conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Early Point-of-Service Social and Behavioral Determinants of Health (SBDOH) Screening and Enhanced Navigation on Care Delivery for Patients With Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Social Determinants of Health (SDOH)
Interventions: OTHER: Early Point-of-Service Social and Behavioral Determinants of Health (SBDOH) Screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study of LY2189102 in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: LY2189102|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 6-month Study to Evaluate the Efficacy and Safety of Fluticasone Furoate (FF)/GW642444 Inhalation Powder in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: FF/GW642444 Inhalation Powder|DRUG: FF Inhalation Powder|DRUG: GW642444 Inhalation Powder|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Efficacy of RUTI® Against SARS-COV-2 Infection (COVID-19) in Healthcare Workers
Status: UNKNOWN
Conditions: Covid-19|Sars-CoV2
Interventions: BIOLOGICAL: RUTI® vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dasotraline Pediatric ADHD Study
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Dasotraline|DRUG: Dasotraline|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 2% Lidocaine Gel in Reducing Postoperative Pain Following Haemorrhoidectomy
Status: RECRUITING
Conditions: Surgery|Pain, Postoperative
Interventions: DRUG: 2% Lidocaine Gel|DRUG: Water-based Lubricant Gel (K-Y Gel)|DRUG: Standard Postoperative Analgesics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Satisfaction With Nurse Administered Propofol Sedation vs. Midazolam With Fentanyl Sedation for Endoscopy
Status: COMPLETED
Conditions: Inflammatory Bowel Disease|Endoscopy|Sedation
Interventions: DRUG: Propofol|DRUG: Midazolam|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Safety and Activity of Aldoxorubicin Plus Gemcitabine in Subjects With Metastatic Solid Tumors
Status: COMPLETED
Conditions: Metastatic Solid Tumors
Interventions: DRUG: aldoxorubicin|DRUG: aldoxorubicin|DRUG: aldoxorubicin|DRUG: gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Efficacy of Poziotinib, Pan HER Inhibitor in Recurrent/Metastatic Esophageal Cancer (R/M ESCC)
Status: UNKNOWN
Conditions: Inoperable or Recurrent or Metastatic Esophageal Squamous Carcinoma
Interventions: DRUG: Treatment with Poziotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of BDB-001 in Severe COVID-19 With ALI/ARDS
Status: TERMINATED
Conditions: COVID-19 Pneumonia
Interventions: DRUG: BDB-001 Injection|OTHER: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-Operative Metrics With CENTURION® and INFINITI® Vision Systems
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: CENTURION® Vision System (CVS)|DEVICE: INFINITI® Vision System (IVS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Comparing Omeprazole With Fluoxetine for Treatment of Non Erosive Reflux Disease and Its Subgroups: a Double-blind Placebo-controlled Clinical Trial
Status: COMPLETED
Conditions: Non-erosive Reflux Disease
Interventions: DRUG: Fluoxetine|DRUG: Omeprazole|DRUG: placebo|DRUG: Omeprazole|DRUG: Fluoxetine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Type 2 Diabetes With Vitamin D Supplementation
Status: COMPLETED
Conditions: Prediabetes
Interventions: DIETARY_SUPPLEMENT: vitamin D + diet and lifestyle|DIETARY_SUPPLEMENT: Placebo + diet and lifestyle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Prurisol Administered Orally for Active Moderate to Severe Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Chronic Stable Plaque Psoriasis
Interventions: DRUG: Placebo|DRUG: 400 mg (200 mg BID)|DRUG: 300 mg (150 mg BID)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: COmplex Bifurcation PCI: AXXESS Device + Absorb BVS, vs Modified T Stenting With Absorb BVS
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: Coronary Bifurcation PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation on the Incidence and Course of COVID-19 in Patients With Prior, Ongoing or de Novo ITP. Evaluation of the Impact of COVID-19 Pandemic on the Management of ITP
Status: UNKNOWN
Conditions: Immune Thrombocytopenia|ITP|Covid19|ITP Secondary to Infection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combined Use of a Novel Cardioplegic Formula With Myocardial Protection System (MPS)® Versus Cardioplexol ® in Isolated Coronary Artery Bypass Grafting (CABG) Using MiECC;
Status: COMPLETED
Conditions: Complication of Extracorporeal Circulation|Complication of Coronary Artery Bypass Graft
Interventions: PROCEDURE: use of a cardioplegic formula in isolated CABG (coronary artery bypass grafting) using MiECC (Minimal extracorporeal circulation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: (EXPLORER) Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid Malignancies
Status: COMPLETED
Conditions: Aggressive Systemic Mastocytosis|Systemic Mastocytosis-associated Hematologic Non-mast Cell Disease|Mast Cell Leukemia|Relapsed or Refractory Myeloid Malignancies
Interventions: DRUG: Avapritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema
Status: COMPLETED
Conditions: Genetic Disorders
Interventions: DRUG: i.v. recombinant human C1 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraperitoneal Polypropylene Light Weight Wide Pore Soft Mesh Repair for Complex Ventral Hernia.
Status: COMPLETED
Conditions: Ventral Hernia
Interventions: PROCEDURE: Intraperitoneal Mesh hernia repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Melphalan and Panobinostat (LBH589) for the Treatment of Patients With Recurrent Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Melphalan|DRUG: Panobinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-Center Study to Determine the Role of Fatty Acids in Serum in Preventing Retinopathy of Prematurity (MDM)
Status: COMPLETED
Conditions: Ophthalmological Disorder
Interventions: DIETARY_SUPPLEMENT: Formulaid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Jaktinib in Patients With COVID-19 Pneumonia.
Status: NOT_YET_RECRUITING
Conditions: COVID-19 Pneumonia
Interventions: DRUG: Jaktinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Penile Length Restoration in Men With Diabetes Mellitus, Type II
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Penile Diseases
Interventions: DEVICE: RestoreX PTT - 6 months|DEVICE: RestoreX PTT - 3 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Sweet Kids Study (Stevia on Weight and Energy Effect Over Time)
Status: RECRUITING
Conditions: Weight Gain|Adiposity|Insulin Sensitivity|Microbial Colonization
Interventions: OTHER: Sucrose sweetened beverage|OTHER: Stevia sweetened beverages|OTHER: Calorie free flavored water beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Computer-Aided Versus Clinical Simulation Sessions on Knowledge, Attitude and Practice of Ergonomics
Status: UNKNOWN
Conditions: Occupational Problems
Interventions: OTHER: Computer-aided sessions|OTHER: Clinical simulation sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intranasal Ketorolac Tromethamine (SPRIX) as a Short Term Pain Management of Post-Vasectomy Pain
Status: UNKNOWN
Conditions: Post Vasectomy Pain
Interventions: DRUG: Ketorolac Tromethamine|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy, Safety and PD and PK of HBM9161 in MG Patients
Status: COMPLETED
Conditions: Myasthenia Gravis
Interventions: DRUG: HBM9161 Injection (680mg and 340 mg)|DRUG: Placebos|DRUG: HBM9161 Injection (340 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: In-office and Domiciliary Use of a New Ozonized Gel for the Management of Periodontal Disease
Status: COMPLETED
Conditions: Periodontal Diseases
Interventions: OTHER: Chlorhexidine|OTHER: Ozoral gels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Clinical Outcomes of the Arthroscopic and Open Modified Broström Operation in CLAI and GJL
Status: COMPLETED
Conditions: Ankle Sprains|Instability, Joint|Joint Hypermobility
Interventions: PROCEDURE: Open or arthroscopic Modified Broström operation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Goal-directed Hemodynamic Therapy on Short-term Postoperative Complications in Patients With Extensive Burns
Status: COMPLETED
Conditions: Hemodynamics
Interventions: PROCEDURE: Goal-directed hemodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Anti-CD19 Universal CAR-NK Cells Therapy Combined With HSCT for B Cell Hematologic Malignancies
Status: WITHDRAWN
Conditions: B-cell Lymphoma|B-cell Leukemia
Interventions: BIOLOGICAL: anti-CD19 UCAR-NK cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating an Online Training Program on Shared Decision-making in Prenatal Screening
Status: COMPLETED
Conditions: Shared Decision Making
Interventions: OTHER: Online Training - Shared Decision Making in Prenatal Screening|OTHER: Online Training - Online Training on Prenatal Screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Laparoscopic Versus Open Right Hemicolectomy Within ERAS in Right-sided Colon Cancer
Status: COMPLETED
Conditions: Colon Cancer
Interventions: PROCEDURE: Laparoscopic right hemicolectomy plus ERAS|PROCEDURE: Open right hemicolectomy plus ERAS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of Open-angle Glaucoma Subjects on Two Topical Hypotensive Medication Treated With Two iStents
Status: COMPLETED
Conditions: Subjects With Primary Open-angle Glaucoma (POAG)
Interventions: DEVICE: iStents
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT