pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Harmony: A Combined MI and BCT Intervention to Reduce Intimate Partner Violence and Alcohol Use in South India
Status: RECRUITING
Conditions: Intimate Partner Violence|Alcohol Use Disorder
Interventions: BEHAVIORAL: Motivational Interviewing (MI) and Behavioral Couples Therapy (BCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Erlotinib (Tarceva®) in Combination With OSI-906 in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) With Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) Gene
Status: COMPLETED
Conditions: NSCLC|Non Small Cell Lung Cancer
Interventions: DRUG: OSI-906|DRUG: Erlotinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ketamine Analgesia in Third Molar Surgery
Status: COMPLETED
Conditions: Pain|Postoperative
Interventions: DRUG: S-Ketamine|DRUG: Sodium Chloride 0.9% Inj
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Long-term Safety, and Efficacy of Brivaracetam (BRV) Used as Adjunctive Treatment in Subjects With Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Brivaracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of TAK-875 to Placebo as an Add-on to Glimepiride in Patients With Type 2 Diabetes
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: TAK-875|DRUG: TAK-875 Placebo|DRUG: Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Pulse Oximetry on Hospital Referral Acceptance in Children Under 5 With Severe Pneumonia
Status: COMPLETED
Conditions: Severe Pneumonia|Hypoxemia
Interventions: DEVICE: Pulse Oximetry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: PICO Venous Leg Ulcers (VLU) Reimbursement Study
Status: RECRUITING
Conditions: Venous Insufficiency|Venous Leg Ulcer
Interventions: DEVICE: PICO Treatment|DEVICE: Standard of Care (SOC) Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "Cuffed Versus Uncuffed Tracheal Tubes in Small Children"
Status: COMPLETED
Conditions: Need for Tracheal Tube Exchange|Presence of Post-extubation Laryngeal Oedema
Interventions: DEVICE: Intubation using tracheal tubes with or without cuff
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: QTc Study GSK573719+GW642444
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Placebo Moxifloxacin|DRUG: Moxifloxacin|DRUG: GSK573719/Vilanterol 125/25mcg|DRUG: GSK573719|DRUG: GSK573719/Vilanterol 500/100mcg|DRUG: Placebo DPI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ostomy Simulation for Patient Education Prior to Urologic Bowel Diversion Surgeries
Status: RECRUITING
Conditions: Ostomy|Ileal Conduit
Interventions: DEVICE: 3D Ostomy simulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based Therapy
Status: UNKNOWN
Conditions: Diabetes Mellitus|Iron Metabolism Disorders|Gastroduodenal Ulcer|Optic Atrophy|Sensorineural Hearing Loss|Platelet Dysfunction
Interventions: DRUG: Deferiprone|DRUG: Acetylcysteine|DRUG: Sitagliptin and Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ezurpimtrostat Autophagy Inhibitor in Association With Atezolizumab-Bevacizumab in First Line Treatment of Unresectable Hepatocellular Carcinoma
Status: TERMINATED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Ezurpimtrostat|DRUG: Atezolizumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of BKM120 in Advanced Squamous Cell Carcinoma of Head and Neck
Status: UNKNOWN
Conditions: Head Neck Cancer Squamous Cell Metastatic|Head Neck Cancer Squamous Cell Recurrent
Interventions: DRUG: BKM120
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An 8-week Full Face HUT Clinical Trial for HydroBoost (2.0/3.0)
Status: COMPLETED
Conditions: Adult Skin Healthy Signs
Interventions: COMBINATION_PRODUCT: Group 1|COMBINATION_PRODUCT: Group 2|COMBINATION_PRODUCT: Group 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Role of CYP2C19 on the Eradication of H. Pylori Infection:Implication of PK/PD Relationships
Status: UNKNOWN
Conditions: Peptic Ulcer With H. Pylori Infection|Gastritis With H. Pylori Infection
Interventions: DRUG: Rabeprazole vs. Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Video Based Training and Aerobic Exercise Training in Individuals With Internet Gaming Disorder
Status: COMPLETED
Conditions: Gaming Disorder|Sedentary Behavior
Interventions: OTHER: aerobic exercise|OTHER: Video based exercise|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Web-based Management of Pediatric Functional Abdominal Pain
Status: COMPLETED
Conditions: Gastrointestinal Disorders, Functional
Interventions: BEHAVIORAL: Online Cognitive Behavior Therapy|BEHAVIORAL: Online Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: JetStream (JS) Atherectomy in Femoropopliteal In-Stent Restenotic Lesions
Status: COMPLETED
Conditions: Restenosis|Peripheral Vascular Disease
Interventions: DEVICE: JetStream Navitus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest of the Reborn® Doll as a TO in the Care of Residents With Alzheimer's Disease or a Related Disorder
Status: NOT_YET_RECRUITING
Conditions: Dementia Alzheimers
Interventions: DEVICE: Reborn doll (Therapeutic object - OT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: GEfitinib Plus viNOrelbine in Advanced EGFR Mutated NSCLC. GENOA Trial
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: oral vinorelbine|DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Movement Tracking Devices to Monitor Physical Activity in Patients Undergoing Chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Neoplasm
Interventions: DEVICE: Accelerometer|OTHER: Laboratory Biomarker Analysis|OTHER: Physical Activity Measurement|BEHAVIORAL: Telephone-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Traveler's Diarrhea (TD) Automated Process
Status: COMPLETED
Conditions: Prevention of Travelers' Diarrhea
Interventions: BIOLOGICAL: heat-labile enterotoxin of E. coli (LT)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cardiac Sarcoidosis Response To Steroids Trial
Status: WITHDRAWN
Conditions: Cardiac Sarcoidosis|Sarcoidosis
Interventions: DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Telephone Counselling to Improve Exercise Participation in Hematologic Cancer Survivors
Status: COMPLETED
Conditions: Leukemia|Lymphoma|Lymphoma, Non-Hodgkin|Behavior, Health
Interventions: BEHAVIORAL: Telephone counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: selexipag (Uptravi)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Volumetric Changes and Graft Stability in Lateral Window Sinus Augmentation: A Prospective Clinical Trial
Status: COMPLETED
Conditions: Lateral Window Sinus Augmentation
Interventions: DEVICE: Allograft bone alone|DEVICE: Allograft and xenograft mixture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bexarotene and GM-CSF in Treating Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases
Interventions: BIOLOGICAL: sargramostim|DRUG: bexarotene|GENETIC: cytogenetic analysis|GENETIC: fluorescence in situ hybridization|OTHER: flow cytometry|OTHER: laboratory biomarker analysis|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correlation Between Myocardial Injury and Intestinal Flora Changes Associated With Oncology Drug Therapy and the Preventive of Probiotics
Status: NOT_YET_RECRUITING
Conditions: Cancer Therapy-related Cardiovascular Toxicity
Interventions: DRUG: Bifidobacterium Bifidum Oral Capsule|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Atlizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Cognitive and Negative Symptoms in Schizophrenia With N-acetylcysteine
Status: COMPLETED
Conditions: Schizophrenia|Cognitive Deficits|Schizophrenia; Negative Type
Interventions: DRUG: N-acetylcysteine|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of ARQ 197 in Combination With Sorafenib in Adult Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: Treatment with ARQ 197 in combination with sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Paclitaxel/Carboplatin With or Without CDP791 in Patients With Lung Cancer
Status: COMPLETED
Conditions: Carcinoma|Non-Squamous Non-Small-Cell Lung Cancer
Interventions: DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: CDP791 10mg/kg|DRUG: CDP791 20mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Combination With Radiotherapy in Locally Advanced Non-Small Cell Lung Cancer (NSCLC)
Status: WITHDRAWN
Conditions: Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: Pembrolizumab|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Dose Study of PRX003 in Healthy Subjects
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: PRX003|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EDTA Eye Drops Compared to Abreva for Herpes Simplex Virus Eruptions
Status: ENROLLING_BY_INVITATION
Conditions: Herpes Simplex Oral
Interventions: DRUG: EDTA|DRUG: Abreva
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Impact of Crime Group Intervention for Jail Inmates
Status: UNKNOWN
Conditions: Crime|Substance Abuse|HIV Risk|Criminogenic Thinking|Shame
Interventions: BEHAVIORAL: Impact of Crime group intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Education of Pregnant Women at Risk of Gestational Diabetes
Status: UNKNOWN
Conditions: Pregnant Women|Gestational Diabetes
Interventions: BEHAVIORAL: Education on preventive health behaviors based on Pender's Health Promotion Model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Transverse Abdominal Plane Anesthesia for Abdominal Wall Reconstruction
Status: WITHDRAWN
Conditions: Hernia, Ventral
Interventions: DRUG: EXPAREL|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Ultrasound-Guided Gastroenterostomy for Malignant Gastric Outlet Obstruction
Status: UNKNOWN
Conditions: Malignant Gastric Outlet Obstruction
Interventions: PROCEDURE: EUS-guided gastroenterostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Femoral Versus Adductor Canal Continuous Peripheral Nerve Blocks for Knee Arthroplasty
Status: COMPLETED
Conditions: Postoperative Pain Following Knee Arthroplasty
Interventions: DRUG: Control: Femoral perineural local anesthetic infusion|DRUG: Experimental: Adductor Canal perineural local anesthetic infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fruquintinib Plus Irinotecan in the Treatment of Advanced Gastric Cancer
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Fruquintinib|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peposertib and Radiation Therapy, Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma
Status: RECRUITING
Conditions: Glioblastoma|Gliosarcoma
Interventions: DRUG: Peposertib|RADIATION: Radiation Therapy|PROCEDURE: Resection|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Namilumab (MT203) for Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Namilumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PRospective Observation on CErebral microvaScular Structure and Function
Status: NOT_YET_RECRUITING
Conditions: Cerebral Microvascular Dysfunction|Cerebral Small Vessel Diseases|Cognitive Dysfunction|Cerebrovascular Disorders|Cardiovascular Diseases|Population
Interventions: OTHER: Without any intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: L-Carnitine Administration in Early Sepsis
Status: TERMINATED
Conditions: Septic Shock
Interventions: DRUG: L-Carnitine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety, Tolerability and Immune Response in Adults Allergic to Peanut After Receiving Intradermal or Intramuscular Administration of ASP0892 (ARA-LAMP-vax), a Single Multivalent Peanut (Ara h1, h2, h3) Lysosomal Associated Membrane Protein DNA Plasmid Vaccine
Status: COMPLETED
Conditions: Peanut Allergy
Interventions: DRUG: ASP0892 Intradermal|DRUG: ASP0892 Intramuscular|DRUG: Placebo Intradermal|DRUG: Placebo Intramuscular
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transarterial Chemoembolization (TACE) With Radiation Therapy (RT) in Advanced Hepatocellular Carcinoma (HCC)
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma|Portal Vein Tumor Thrombosis
Interventions: RADIATION: Scheduled interval TACE - RT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Utility of Minocycline as an Anti-Inflammatory Agent in the Treatment of Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: minocycline|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Molecular Mechanism of Botulinum Toxin in the Reduction of Breast Reduction Mammoplasty Scar Formation
Status: ENROLLING_BY_INVITATION
Conditions: Scar|Hypertrophic Scar|Mammary Disorder
Interventions: DRUG: Botulinum Toxins|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Double-blind, Randomized Controlled Study to Assess the Analgesic Effect of 2 g of Magnesium Dipyrone (Metamizol) and Changes in Plasma Beta-endorphin Immunoreactivity Values in Patients Undergoing Elective Inguinal Herniorrhaphy Under Epidural Anesthesia.
Status: COMPLETED
Conditions: Pain|Beta-endorphin|Dipyrone|Hernia Surgery
Interventions: DRUG: Dipyrone administration|BEHAVIORAL: Pain assessment|BIOLOGICAL: beta-endorphin immunoreactivity|OTHER: Placebo administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Cetuximab in Combination With Tarceva in Patients With Solid Tumors
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Cetuximab + Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Engagement With Technology-assisted Treatment
Status: COMPLETED
Conditions: Alcoholism|Substance-related Disorders|Mentally Ill Chemical Abuse|Educational Technology
Interventions: DEVICE: Therapeutic Education System (TES)|OTHER: Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study for Aortic Arch Therapy With stENt-graft for Chimney technologY（PATENCY）
Status: ENROLLING_BY_INVITATION
Conditions: Thoracic Aortic Dissection
Interventions: DEVICE: Artery Stent Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Therapy in Treatment of Patients With Helicobacter Pylori Infection: Concomitant Versus Hybrid Therapy.
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Concomitant therapy|DRUG: Concomitant therapy|DRUG: Concomitant therapy|DRUG: Concomitant therapy|DRUG: Hybrid therapy|DRUG: Hybrid therapy|DRUG: Hybrid therapy|DRUG: Hybrid therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Tolerance of Tacrolimus Sustained-release Capsules on Refractory Nephrotic Syndrome (RNS)
Status: COMPLETED
Conditions: Nephrotic Syndrome
Interventions: DRUG: Tacrolimus Sustained-release Capsules (ADVAGRAF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intensive Versus Regular Dosage For PD In AKI.
Status: TERMINATED
Conditions: Peritoneal Dialysis|Acute Kidney Injury
Interventions: PROCEDURE: Intensive dosage of PD|PROCEDURE: Regular dosage of PD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IntelliCare Study: Artificial Intelligence in a Mobile (AIM) Intervention for Depression
Status: COMPLETED
Conditions: Depression|Anxiety
Interventions: BEHAVIORAL: IntelliCare|BEHAVIORAL: Hub App with the Recommender System|BEHAVIORAL: Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Obeticholic Acid for Lipodystrophy Patients
Status: COMPLETED
Conditions: Familial Partial Lipodystrophy
Interventions: DRUG: Obeticholic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Oligopin® on Blood Pressure.
Status: COMPLETED
Conditions: Blood Pressure|Hypertension
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Oligopin®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Safety and Efficacy Study of UHE-101 Cream in Subjects With Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: UHE-101 Cream|OTHER: Vehicle Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pexacerfont for Stress-induced Food Craving
Status: TERMINATED
Conditions: Daily Oral Pexacerfont for 28 Days (300 mg/Day Loading Dose for 7 Days, Followed|Placebo
Interventions: DRUG: Pexacerfont
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Inorganic Nitrates (Beetroot Juice) on Arterial Hemodynamics and Exercise Capacity
Status: COMPLETED
Conditions: Heart Failure With Normal Ejection Fraction
Interventions: DIETARY_SUPPLEMENT: Nitrate rich beetroot juice|DIETARY_SUPPLEMENT: Nitrate depleted beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antibiotic Combination for H. Pylori Eradication in Penicillin-allergic Patients
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Rabeprazole|DRUG: Bismuth potassium citrate|DRUG: Metronidazole|DRUG: Clarithromycin|DRUG: Levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunosuppressive Drugs and Gut Microbiome: Pharmacokinetic- and Microbiome Diversity Effects
Status: ACTIVE_NOT_RECRUITING
Conditions: Kidney Transplant; Complications|Immune Suppression
Interventions: DRUG: Mycophenolate Mofetil 500 mg Tab|DRUG: Tacrolimus capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Continuous Glucose Monitoring to Assess Glycemia in Chronic Kidney Disease - Changing Glucose Management
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Type 2 Diabetes
Interventions: DRUG: Linagliptin|DRUG: Glipizide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-operative Hormonal Treatment for Hormone Receptor Positive Breast Cancer
Status: SUSPENDED
Conditions: Breast Cancer
Interventions: DRUG: Anastrozole|DRUG: Anastrozole+Fulvestrant|DRUG: Tamoxifen|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: SWESS: The SWedish Exercise Shoulder Study in Primary Care for Patients With Subacromial Pain
Status: COMPLETED
Conditions: Shoulder Pain|Shoulder Impingement Syndrome|Disorder of Rotator Cuff|Subacromial Bursitis
Interventions: OTHER: Specific exercise group|OTHER: Control exercise group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder, Major|Depression|Depressive Disorder
Interventions: GENETIC: GeneSight Psychotropic (GEN)|GENETIC: Enhanced-GeneSight Psychotropic (E-GEN)|OTHER: Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Abuse Liability of a Novel Heated Tobacco Product (IQOS) and Its Feasibility as a Menthol Cigarette Substitute
Status: COMPLETED
Conditions: Tobacco Use
Interventions: DEVICE: Tobacco product administration and assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Crossover Study to Assess the Bioequivalence of Hydrocodone Bitartrate Extended-Release Tablet
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: 90 mg dose of the hydrocodone bitartrate extended-release tablet administered as either two 45-mg tablets (Treatment A) or one 90-mg tablet (Treatment B).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Dose Proportionality Study of Canagliflozin in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Canagliflozin, 50 mg|DRUG: Canagliflozin, 300 mg|DRUG: Canagliflozin, 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Dose Escalation Study of CyberKnife® SBRT Boost for Patients With Unresectable Locally Advanced Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Carcinoma Non-resectable
Interventions: RADIATION: CyberKnife® Stereotactic Body Radiotherapy(SBRT)Boost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Orange Juice And Sugar Intervention Study
Status: COMPLETED
Conditions: Cardiovascular Risk Factor|Type2 Diabetes Mellitus|Insulin Sensitivity|Metabolic Syndrome
Interventions: OTHER: Naturally-sweetened orange juice|OTHER: Sugar-sweetened beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Subcutaneous Implantable Cardiac Defibrillator in Brugada Patients
Status: COMPLETED
Conditions: Brugada Syndrome|S-ICD System (Implantable Defibrillator)
Interventions: DEVICE: S-ICD System (implantable defibrillator)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Oligonol to Cardiometabolic Risk and Muscular Health
Status: COMPLETED
Conditions: Muscle Loss|Muscle Weakness|Quality of Life
Interventions: DIETARY_SUPPLEMENT: Oligonol intake|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Functional Results With Attune Fixed Bearing Posterior Stabilized Knee Arthroplasty (A-16)
Status: UNKNOWN
Conditions: Knee Arthroplasty
Interventions: DEVICE: Attune FB PS knee arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Research of Systemic Management for Late Preterm Infants Nutrition in China
Status: UNKNOWN
Conditions: Late Premature Infants|Systemic Nutritional Management
Interventions: PROCEDURE: new systemic nutrition management protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of the Use of the Nintendo Switch Combined With Conventional Therapy in People With Acquired Brain Injury
Status: RECRUITING
Conditions: Occupational Therapy|Acquired Brain Injury|Adults
Interventions: PROCEDURE: Conventional therapy sessions|PROCEDURE: Conventional therapy sessions plus Nintendo Switch
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Influenza Vaccination on Donor Egg Recipient Outcomes
Status: UNKNOWN
Conditions: Infertility|Recurrent Miscarriage
Interventions: BIOLOGICAL: Influenza Vaccine|OTHER: Sterile Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle
Status: RECRUITING
Conditions: Brain Mapping|Healthy Volunteer
Interventions: OTHER: NSR MAGNETOM 7T|OTHER: 1Tx x 32Rx Head Coil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation Of The Efficacy Of HalfLYTELY For Bowel Cleansing Before Virtual Colonoscopy and Conventional Colonoscopy.
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: HalfLytely
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Safety and Efficacy Study of Allogeneic Adipose-derived Stem Cells for Treatment of Lateral Epicondylitis
Status: COMPLETED
Conditions: Tennis Elbow
Interventions: BIOLOGICAL: ALLO-ASC-TI|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Photorefractive Keratectomy (PRK), PRK With Mitomycin-C and Laser Subepithelial Keratomileusis (LASEK) in the Treatment of Moderate and High Myopia
Status: TERMINATED
Conditions: MODERATE AND HIGH MYOPIA
Interventions: PROCEDURE: PRK|PROCEDURE: MMC PRK|PROCEDURE: LASEK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of 2-octylcyanoacrylate (Dermabond) Versus 5-0 Fast Absorbing Gut During Cutaneous Wound Closure
Status: COMPLETED
Conditions: Wound Closure Techniques
Interventions: PROCEDURE: Wound Closure with 2-octylcyanoacrylate|PROCEDURE: Wound Closure with 5-0 Fast Absorbing Gut Sutures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Brain Injury Education and Outpatient Navigation-1stBIEN
Status: RECRUITING
Conditions: Brain Injuries, Traumatic|Rehabilitation
Interventions: BEHAVIORAL: Bilingual Brain Injury Education and outpatient Navigation for Hispanic families
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Integrated Life Skill Training and Executive Function Strategies in Children With ASD
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: OTHER: Executive Function Strategies and Training|OTHER: Daily Life skill training|OTHER: Sensory Integration /Processing training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Distraction in Patients Undergoing Periodontal Surgery
Status: COMPLETED
Conditions: Virtual Reality|Oral Surgery|Dental Anxiety
Interventions: PROCEDURE: Periodontal surgery with virtual reality distraction|PROCEDURE: Periodontal surgery without virtual reality distraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Lacosamide on Post-operative Opioid Requirements After a Total Hip Arthroplasty:
Status: WITHDRAWN
Conditions: Osteoarthritis|Rheumatoid Arthritis|Avascular Necrosis
Interventions: DRUG: Placebo|DRUG: Lacosamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy (CBT) for PTSD in Veterans With Co-Occurring SUDs
Status: COMPLETED
Conditions: PTSD|Substance Use Disorders
Interventions: BEHAVIORAL: Cognitive behavioral therapy for PTSD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term Evaluation of Tubal Expansion on Obstructive Dysfunctions of Eustachian Tube
Status: COMPLETED
Conditions: Eustachian Tube Disorder
Interventions: DEVICE: Balloon catheter for the Eustachian tube
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does a Pre-operative Exercise Program Improve Post-operative Outcomes for Fusion Patients
Status: NOT_YET_RECRUITING
Conditions: Adolescent Idiopathic Scoliosis
Interventions: BEHAVIORAL: Prehabilitation Exercise Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of VDA-1102 Ointment in the Treatment of Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Placebo|DRUG: 5% VDA-1102|DRUG: 10% VDA-1102
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TRanscatheter Aortic-Valve Implantation With or Without On-site Cardiac Surgery: the TRACS Trial
Status: RECRUITING
Conditions: Aortic Stenosis, Severe
Interventions: PROCEDURE: TAVI WITHOUT ON-SITE SURGERY|PROCEDURE: TAVI WITH ON-SITE SURGERY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ALTERRA: SAPIEN 3 THV With the Alterra Adaptive Prestent
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Disease|Transcatheter Pulmonary Valve Replacement (TPVR)|Tetralogy of Fallot|Congenital Heart Disease|Pulmonary Regurgitation
Interventions: DEVICE: Edwards Alterra Adaptive Prestent with SAPIEN 3 THV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Different Antithrombotic Therapy for the Treatment of Ventricular Thrombus
Status: RECRUITING
Conditions: Ventricular Thrombus
Interventions: DRUG: non-vitamin K antagonist oral anticoagulants (NOACs)|DRUG: vitamin K antagonists (VKAs)|DRUG: antiplatelet agents|OTHER: non-antithrombotic therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Ferrous Iron on the Prevention of Vascular Cognitive Impairment Among Patients With Cerebral Infarction/TIA (FAVORITE)
Status: UNKNOWN
Conditions: Vascular Cognitive Impairment|Dementia, Vascular|Iron-deficiency|Cerebral Infarction|TIA
Interventions: DRUG: Ferrous succinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ProSeal Laryngeal Mask Airway (LMA) Size 3 vs 4 in Non-paralyzed Female Patients
Status: COMPLETED
Conditions: Oropharyngeal Injury
Interventions: DEVICE: insertion of the ProSeal LMA (PLMA)|DEVICE: insertion of the PLMA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Reexamining Hypotonic Intravenous Fluid Use
Status: WITHDRAWN
Conditions: Hyponatremia
Interventions: OTHER: 0.9 Normal Saline|OTHER: 0.45 Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: DLBS1449 in Diabetic Patients With Low HDL
Status: WITHDRAWN
Conditions: Diabetic Patients|Low HDL-cholesterol (< 35 mg/dL)|Lifestyle Intervention for at Least 1 Month
Interventions: DRUG: DLBS1449|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fetal Myelomeningocele Repair With Maternal BMI Between 35.0 and 40.0
Status: TERMINATED
Conditions: Myelomeningocele|Pregnancy
Interventions: PROCEDURE: Open Fetal Repair of Myelomeningocele
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Arthroscopic Reconstruction of the Anterior Cruciate Ligament by One Night Hospital Stay or by Day Surgery: a Randomised, Prospective Clinical Trial
Status: COMPLETED
Conditions: Rupture of the Anterior Cruciate Ligament With Instability of the Knee Joint
Interventions: DRUG: injection in the knee joint with 20 ml of chirocaine 0.125%|DRUG: injection in the knee joint with 20 ml of physiological fluid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of a Therapy Change From Candesartan 32 mg to Fixed Combination of Olmesartan 40 mg/Amlodipine 10 mg
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Candesartan cilexetil|DRUG: Olmesartan medoxomil|DRUG: Olmesartan/amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Multicenter Study To Assess The Clinical Outcomes Of Current Phacoemulsification Approach To Cataract Extraction Versus The Micor System Device
Status: ENROLLING_BY_INVITATION
Conditions: Cataract Surgery
Interventions: DEVICE: miCOR System|DEVICE: Phaco Subject Cohort
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy And Safety Of Clopidogrel In Neonates /Infants With Systemic To Pulmonary Artery Shunt Palliation
Status: COMPLETED
Conditions: Heart Defects, Congenital
Interventions: DRUG: Clopidogrel (SR25990)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 24-Hour Intraocular Pressure (IOP) And Blood Pressure Control In Glaucoma And Ocular Hypertension Patients
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: timolol maleate 0.5%|DRUG: latanoprost/timolol fixed combination|DRUG: placebo (artificial tears)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Avastin (Bevacizumab) in Combination With Chemotherapy in Chinese Patients With Metastatic Colorectal Cancer.
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: bevacizumab [Avastin]|DRUG: irinotecan|DRUG: leucovorin|DRUG: fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2, Safety and Dose-Finding Study in Treatment-Naive, Pre-Pubertal, Growth Hormone-Deficient Children
Status: TERMINATED
Conditions: Growth Hormone-Deficiency
Interventions: DRUG: TV-1106|DRUG: somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of NIV and CPAP on Ventilation Distribution, Measured by EIT, During Deep Sedation in Paediatric Patients
Status: RECRUITING
Conditions: Respiratory Failure|Sedation|Mechanical Ventilation Complication
Interventions: DEVICE: EIT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Central Insulin Sensitivity in Individuals With Type 2 Diabetes (T2D) and at Risk for Developing T2D
Status: RECRUITING
Conditions: Central Insulin Resistance|Diabetes Mellitus, Type 2|PreDiabetes
Interventions: OTHER: Human nasal insulin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Colonisation Efficacy of a Probiotic Chewing Gum.
Status: RECRUITING
Conditions: Microbial Colonization
Interventions: DIETARY_SUPPLEMENT: Streptococcus salivarius M18 probiotic 1 billion colony forming units chewing gum (chew 5 minutes)|DIETARY_SUPPLEMENT: Streptococcus salivarius M18 probiotic 1 billion colony forming units chewing gum (chew 10 minutes)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Refametinib (BAY86-9766) in Combination With Regorafenib (Stivarga, BAY73-4506) in Patients With Advanced or Metastatic Cancer
Status: TERMINATED
Conditions: Neoplasms
Interventions: DRUG: Refametinib (BAY86-9766)|DRUG: Regorafenib (Stivarga, BAY73-4506)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PXVX0200 (CVD103-HgR) vs Shanchol in Mali
Status: COMPLETED
Conditions: Cholera
Interventions: BIOLOGICAL: PXVX0200 10E8|BIOLOGICAL: PXVX0200 10E9|BIOLOGICAL: Placebo|BIOLOGICAL: Shanchol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Doxazosin and Ramipril in Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Ramipril|DRUG: Doxazosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Characterize the Biological Effect of a Pre-planned 12 Week Dose Interruption of Natalizumab
Status: UNKNOWN
Conditions: Multiple Sclerosis|Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Dosing Interruption of Natalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of PR022 Topical Gel to Treat Mild-to-Moderate Atopic Dermatitis
Status: UNKNOWN
Conditions: Atopic Dermatitis
Interventions: DRUG: PR022
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Low Dose Aspirin for the Prevention of Postpartum Related Breast Cancer
Status: RECRUITING
Conditions: Benign Breast Neoplasm|Breast Carcinoma|Breast Fibrocystic Change
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Low-Dose Aspirin|OTHER: Questionnaire Administration|PROCEDURE: Ultrasound-Guided Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: MEK Inhibitor AZD6244 in Treating Patients With Stage III or Stage IV Melanoma
Status: COMPLETED
Conditions: Recurrent Melanoma|Stage III Skin Melanoma|Stage IV Skin Melanoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Selumetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Dabrafenib in Combination With Trametinib in Chinese Patients With BRAF V600E Mutant Metastatic NSCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Dabrafenib|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Iliac Stents to Treat TASC A-B-C-D Iliac Artery Lesions
Status: COMPLETED
Conditions: Peripheral Vascular Disease|Intermittent Claudication|Critical Limb Ischemia
Interventions: DEVICE: iliac stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Daratumumab, Bortezomib, Cyclophosphamide, and Dexamethasone Therapy for Patients With MIDD
Status: RECRUITING
Conditions: Monoclonal Gammopathy of Renal Significance
Interventions: DRUG: Dara-CyBorD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT