pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluating the Safety and Immune Response to an H5N1 Influenza Vaccine in People Who Have Previously Received an H5N1 or H7N3 Influenza Vaccine and in People Who Have Never Received a Live Attenuated Influenza Vaccine
Status: COMPLETED
Conditions: H5N1 Influenza
Interventions: BIOLOGICAL: H5N1 Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study With BIBF 1120 in Patients With Hormone Refractory Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: BIBF 1120 low dose|DRUG: BIBF 1120 high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Post-market Study to Evaluate the Effects of Sodium Hyaluronate Based Eye Drops in Patients Affected by Dry Eye Disease
Status: RECRUITING
Conditions: Opthalomology/Dry Eye
Interventions: DEVICE: Irilens; Iridina; Afomill Lubricating Eye Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of 0.1 and 0.05mg Intrathecal Morphine for Post-cesarean Analgesia.
Status: COMPLETED
Conditions: Cesarean Section
Interventions: DRUG: receiving 0.1 mg IT morphine|DRUG: recieving 0.05 mg IT morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Kinesio Taping on Upper Extremity Performance in Individuals With Rounded Shoulders
Status: COMPLETED
Conditions: Shoulder Pain
Interventions: OTHER: Kinesio tape, functional correction technique|OTHER: Elastic band strengthening shoulder exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Pharmacokinetics, Safety and Tolerability Between Fixed-Dose Combination of HCP1904 and Co-Administration of RLD2001-2 and RLD2006 Tablets in Healthy Subjects.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HCP1904-1|DRUG: RLD2006|DRUG: RLD2001-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Osseodensification on Implant Stability in Posterior Maxilla
Status: UNKNOWN
Conditions: Implant Stability
Interventions: DEVICE: Densah Burs|DEVICE: Standard drills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-blind, Placebo Controlled Phase III Study to Investigate Efficacy and Safety of HLX10 + Chemotherapy (Carboplatin- Etoposide) in Patients With Extensive Stage Small Cell Lung Cancer (ES-SCLC)
Status: UNKNOWN
Conditions: Extensive Stage Small Cell Lung Cancer
Interventions: DRUG: HLX10|DRUG: carboplatin and etoposide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of MRI Labeling Technique to Track Mesenchymal Stem Cell Survival in Orthopaedic Conditions
Status: WITHDRAWN
Conditions: Cartilage Degeneration|Rotator Cuff Tear|Osteoarthritis, Knee
Interventions: PROCEDURE: arthroscopy of the affected knee/ Bone Marrow Concentrate Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Lanadelumab (SHP643) in Japanese Participants With Hereditary Angioedema (HAE)
Status: COMPLETED
Conditions: Hereditary Angioedema (HAE)
Interventions: DRUG: Lanadelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Prostatic Arterial Embolization in Low-risk Patients With Unilateral Prostate Cancer Under Active Surveillance: Monocentric Pilot Study
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: Embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Lithium Versus Placebo in Adults With Treatment-Resistant Depression Who Are Receiving Ketamine
Status: WITHDRAWN
Conditions: Treatment Resistant Depression
Interventions: DRUG: Lithium|DRUG: Placebo|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate the Effect of Single Doses of LX4211 and Canagliflozin on Intestinal Glucose Absorption in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: LX4211 400 mg|DRUG: canagliflozin 300 mg|DRUG: LX4211 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Whole Body Fluorine F 18 Sodium Fluoride PET/CT Scan and Whole Body MRI in Finding Bone Metastases in Patients With Prostate Cancer
Status: COMPLETED
Conditions: Bone Metastases|Recurrent Prostate Cancer|Stage I Prostate Cancer|Stage IIA Prostate Cancer|Stage IIB Prostate Cancer|Stage III Prostate Cancer|Stage IV Prostate Cancer
Interventions: PROCEDURE: magnetic resonance imaging|RADIATION: fluorine F 18 sodium fluoride|PROCEDURE: positron emission tomography|PROCEDURE: computed tomography|RADIATION: technetium Tc 99m methylene diphosphonate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: QL1706 Plus Chemotherapy as Neoadjuvant Therapy in Early High-Risk ER+/HER2- Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Early Breast Cancer|Neoadjuvant Therapy|HR+HER2- Breast Cancer
Interventions: DRUG: QL1706 (bispecific antibody targeting PD-1 and CLTA-4)|DRUG: Albumin-bound paclitaxel|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Epirubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin and Pioglitazone Effects on YKL-40 Concentrations in Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Metformin|DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Impact of Delflex on Mesothelial Cell Viability and Peritoneal Transport
Status: WITHDRAWN
Conditions: End Stage Renal Disease
Interventions: OTHER: Active Comparator: Conventional peritoneal dialysis solution|OTHER: Experimental: Novel biocompatible dialysis solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety and Tolerability of BHV-7000
Status: ENROLLING_BY_INVITATION
Conditions: Focal Epilepsy
Interventions: DRUG: BHV-7000|DRUG: BHV-7000
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Bacterial Composition of the Stomach in Reflux Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: GORD|Oesophageal Cancer|Oesophageal Reflux|Gastric Cancer|Gastro Esophageal Reflux|Oesophageal Carcinoma|Barrett Esophagus|Esophagitis
Interventions: DIAGNOSTIC_TEST: No intervention but patients are undergoing an upper GI endoscopy and biopsies for clinical purposes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Foam Rolling Prior to PNF Stretching on Hamstring Flexibility and Thigh Skin Temperature in Healthy Subjects
Status: UNKNOWN
Conditions: Healthy
Interventions: OTHER: PNF stretching|OTHER: Non-vibration foam rolling prior to PNF stretching|OTHER: Vibration foam rolling prior to PNF stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pre-incisional Wound INfiltration and Hypogastric PLEXus Block Using Ropivacaine in Laparoscopic Myomectomy
Status: RECRUITING
Conditions: Fibroid Uterus|Pain, Postoperative
Interventions: PROCEDURE: Infiltration of the anterior abdominal wall|PROCEDURE: Upper hypogastric plexus blockade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Trial to Investigate the Safety and Between-group Effect Size of STIMULAN VG and Standard of Care (SoC) in Participants With Diabetic Foot Osteomyelitis
Status: RECRUITING
Conditions: Diabetic Foot Osteomyelitis
Interventions: DRUG: STIMULAN VG|DRUG: Systemic Antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Erenumab-aooe in Patients With Temporomandibular Disorder
Status: COMPLETED
Conditions: Temporomandibular Disorder
Interventions: DRUG: Erenumab-aooe (EREN) 140 mg s.c. administered every four weeks for a total of five treatments|DRUG: Placebo (EREN-P) s.c. administered every four weeks for a total of five treatments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of an Intervention to Improve Metformin Persistence and Adherence
Status: COMPLETED
Conditions: Metformin Adverse Reaction|Tolerance
Interventions: DRUG: Metformin Extended Release Oral Tablet|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic of D-lactate in Cerebrospinal Fluid Level in Patients With Suspected Ventriculostomy-related Meningitis
Status: NOT_YET_RECRUITING
Conditions: Nosocomial Infection
Interventions: BIOLOGICAL: CSF sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Drug-Drug Interaction Study of Ambroxol and Levodropropizine
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ambroxol and Levodropropizine|DRUG: Ambroxol|DRUG: Levodropropizine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Panobinostat in Combination With Carfilzomib and Dexamethasone in Relapsed or Relapsed and Refractory Multiple Myeloma
Status: WITHDRAWN
Conditions: Multiple Myeloma
Interventions: DRUG: panobinostat (capsules)|DRUG: carfilzomib (infusion)|DRUG: dexamethasone (tablets)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Tools to Communicate Scleroderma Research Results to Patients
Status: NOT_YET_RECRUITING
Conditions: Scleroderma|Systemic Sclerosis
Interventions: OTHER: Plain-language summary|OTHER: Dissemination Tool (Infographic)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Tobramycin Inhalation Powder (TIP) Administered Once Daily Continuously Versus TIP Administered BID in 28 Day on / 28 Day Off Cycles
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DRUG: Tobramycin Inhalation Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Capecitabine and Tipifarnib in Treating Women With Taxane-Resistant Metastatic Breast Cancer
Status: COMPLETED
Conditions: Recurrent Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: tipifarnib|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Efficacy of ASP015K in Patients With Rheumatoid Arthritis (RA) Who Had an Inadequate Response to DMARDs
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Peficitinib|DRUG: Placebo|BIOLOGICAL: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Harnessing Neuroplasticity to Enhance Functional Recovery During Chronic Recovery From Upper Extremity Nerve Repair
Status: RECRUITING
Conditions: Hand Transplantation|Peripheral Nerve Injuries|Neurologic Rehabilitation
Interventions: DEVICE: Transcranial Direct Current Stimulation|BEHAVIORAL: Modified Constraint Induced Movement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Effects of Systemic Probiotics & Antibiotics and Local Application of Antibiotics as an Adjuvant to NSPT
Status: ACTIVE_NOT_RECRUITING
Conditions: Periodontitis|Adult
Interventions: OTHER: Antibiotics(doxycycline)|OTHER: Probiotics|OTHER: Metronidazole gel 25%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Versus Postoperative Glycemia Control in Cardiac Surgery Patients
Status: COMPLETED
Conditions: Perioperative and Postoperative Hyperglycemia|Tight Glycemia Control
Interventions: PROCEDURE: Intensive glycemia control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Compare the Safety and Efficacy of Genoss® DCB and SeQuent® Please in Korean Patients With Coronary In-stent Restenosis
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Paclitaxel Coated PTCA Balloon Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Dimethyl Fumarate (Tecfidera) and Peginterferon Beta-1a (Plegridy) for the Treatment of Relapsing-Remitting Multiple Sclerosis in Pediatric Participants
Status: TERMINATED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Dimethyl Fumarate|DRUG: Peginterferon Beta-1a|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Chinese Herbal Therapy to Treat Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Anti-Asthma Herbal Medical Intervention (ASHMI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Non-steroidal Anti-inflammatory Drugs (NSAID) on Muscle Regeneration
Status: COMPLETED
Conditions: Muscle Damage
Interventions: DRUG: NSAID|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess the Safety and Pharmacokinetic (PK) of CTP-692 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CTP-692|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thrombocytopenia and Bleeding in Wiskott-Aldrich Syndrome (WAS) Patients
Status: TERMINATED
Conditions: Wiskott-Aldrich Syndrome|Thrombocytopenia|Bleeding
Interventions: DRUG: Promacta|DIAGNOSTIC_TEST: blood drawing in patients with WAS|DIAGNOSTIC_TEST: blood drawing in healthy controls
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DS-1594b With or Without Azacitidine, Venetoclax, or Mini-HCVD for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Recurrent Acute Lymphoblastic Leukemia|Recurrent Acute Myeloid Leukemia|Recurrent Chronic Myelomonocytic Leukemia|Recurrent Myelodysplastic Syndrome|Refractory Acute Lymphoblastic Leukemia|Refractory Acute Myeloid Leukemia|Refractory Chronic Myelomonocytic Leukemia|Refractory Myelodysplastic Syndrome
Interventions: DRUG: DS-1594b|DRUG: Azacitidine|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Dexamethasone|BIOLOGICAL: Filgrastim|DRUG: Leucovorin|DRUG: Mesna|DRUG: Methotrexate|DRUG: Posaconazole|DRUG: Prednisone|BIOLOGICAL: Rituximab|DRUG: Venetoclax|DRUG: Vincristine|DRUG: Voriconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Weight Loss and Stress Reduction in Overweight and Obese Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Overweight and Obesity
Interventions: BEHAVIORAL: Small change intervention|BEHAVIORAL: Well-being intervention|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Pancreatic EUS-FNB With the 20-gauge Procore® and the 22-gauge Acquire® Needles
Status: COMPLETED
Conditions: Pancreas Cancer|Pancreatic Adenocarcinoma
Interventions: DEVICE: 20-GAUGE PROCORE® first, then 22-GAUGE ACQUIRE®|DEVICE: 22-GAUGE ACQUIRE® first, then 20-GAUGE PROCORE®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Preoperative Diet on Perioperative Gut Microbiome
Status: ENROLLING_BY_INVITATION
Conditions: Surgical Site Infection
Interventions: BEHAVIORAL: high-fiber/low fat|BEHAVIORAL: fermented
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Add-on Study of MLR-1023 in Adults With Uncontrolled Type 2 Diabetes on Metformin Therapy
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: MLR-1023|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Drug-Drug Interaction Study to Assess the Effect of Trametinib on the Pharmacokinetics of an Oral Contraceptive in Female Patients With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Trametinib|DRUG: Trametinib|DRUG: Oral Contraceptive (1mg norethindrone, 0.035mg ethinyl estradiol)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Synthetic and Natural Caffeine on Hemodynamic Parameters in Young, Healthy Volunteers
Status: WITHDRAWN
Conditions: Cardiovascular Injury
Interventions: DIETARY_SUPPLEMENT: Natural Caffeine|DIETARY_SUPPLEMENT: Synthetic Caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Pharmacokinetic, Safety and Tolerability Study of SC Administered Bisphosphonate With rHuPH20 vs Bisphosphonate Alone
Status: COMPLETED
Conditions: Risk Factors for or a Diagnosis of Osteoporosis
Interventions: DRUG: rHuPH20|DRUG: zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study of Zolbetuximab (IMAB362) in Adults With Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer|Metastatic Pancreatic Cancer|Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: zolbetuximab|DRUG: nab-paclitaxel|DRUG: gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of Strasbourg Environmental Exposure Chamber ALYATEC in Cat Allergic Subjects With Asthma
Status: COMPLETED
Conditions: Allergic Asthma|Allergy|Allergy to Cats
Interventions: OTHER: Exposure to Placebo|OTHER: Exposure to dose A and dose B of cat allergen|OTHER: Exposure to a single dose of cat allergen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effects of Low-volume HIIT Versus MICT on Physical Performance in Older Adults With Possible Sarcopenia
Status: ACTIVE_NOT_RECRUITING
Conditions: Sarcopenia
Interventions: DEVICE: Ergometer cycling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Potential Effect of Topical Imiquimod on Atrial Ectopy in Patients With Actinic Keratosis
Status: UNKNOWN
Conditions: Actinic Keratosis
Interventions: DRUG: Imiquimod cream 3.75%|DRUG: Placebo cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Stapler Versus Conventional Pharyngeal Repair After Total Larygectomy
Status: COMPLETED
Conditions: Malignant Tumor of the Larynx
Interventions: PROCEDURE: total laryngectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inhaled Iloprost for Disproportionate Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease (COPD)
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Inhaled iloprost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: taVNS on Pupillary Response and Perceptual Learning
Status: RECRUITING
Conditions: Pupillary Response
Interventions: PROCEDURE: Transcutaneous Auricular Vagal Nerve Stimulation (taVNS)|PROCEDURE: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Observe How Adolescent Patients With Severe Atopic Dermatitis Despite Less Extensive Skin Lesions (Eczema Area and Severity Index Score < 16) Respond to Dupilumab Treatment
Status: RECRUITING
Conditions: Dermatitis Atopic
Interventions: DRUG: Dupilumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exercise Study Testing Enhanced Energetics of Mitochondria Video Integrated Delivery of Activity Training in CKD
Status: RECRUITING
Conditions: Moderate-severe Chronic Kidney Disease Not Treated With Dialysis|Diabetic Kidney Disease, HgbA1c Less Than 8.5
Interventions: BEHAVIORAL: Combined Aerobic and Resistance Exercise via videoconferencing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kyphoscoliosis Surgery: Blood Conservation and Analgesia
Status: COMPLETED
Conditions: Posterior Spine Surgery
Interventions: DRUG: Local anesthetic-epinephrine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Individual Boosting in Non-Small Cell Lung Cancer Using Hypofractionation, Intensity-modulated Radiation Therapy and Respiratory Gating
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: PROCEDURE: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amplify Gait to Improve Locomotor Engagement in Spinal Cord Injury
Status: COMPLETED
Conditions: Incomplete Spinal Cord Injury
Interventions: DEVICE: Gait training performed on a treadmill|DEVICE: Gait training performed in a Movement Amplification Environment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pramipexole Dihydrochloride 0.25 mg Tablets Under Non-Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pramipexole Dihydrochloride|DRUG: Pramipexole Dihydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Bronchial Thermoplasty for Severe Asthmatics Guided by HXe MRI
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: HXe MRI guided treatment sequence for BT|OTHER: Standard treatment sequence for BT (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A New Model of Acute Febrile Disease
Status: COMPLETED
Conditions: Immobilization, Tonic|Fasting|Endotoxemia|Metabolism
Interventions: OTHER: LPS, 36 hour immobilization and fast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neuroplasticity-Based Cognitive Remediation for Chemotherapy-Related Cognitive Impairment
Status: COMPLETED
Conditions: Cancer Survivors|Chemotherapy-related Cognitive Impairment
Interventions: BEHAVIORAL: Neuroplasticity-based Computerized Cognitive Remediation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Examination of Infants' Microbiome, Nutrition, and Development Study.
Status: ACTIVE_NOT_RECRUITING
Conditions: Microbial Colonization|Infant Development
Interventions: OTHER: Sweet Potatos|OTHER: Pears
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Poziotinib in Previously Treated Participants With Locally Advanced or Metastatic NSCLC Harboring HER2 Exon 20 Mutations
Status: SUSPENDED
Conditions: NSCLC
Interventions: DRUG: Poziotinib|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Dose Study of SPC4955 in Healthy Subjects
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: SPC4955|DRUG: SPC4955|DRUG: SPC4955|DRUG: SPC4955|DRUG: SPC4955|DRUG: Saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Posterior Innominate Mobilization Versus Muscle Energy Technique on Lumbopelvic Angles in Sacroiliac Joint Dysfunction
Status: RECRUITING
Conditions: Sacroiliac Joint Dysfunction
Interventions: BEHAVIORAL: muscle energy technique|BEHAVIORAL: posterior innominate mobilization|BEHAVIORAL: conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Arthroscopic Assisted Open Reduction Internal Fixation Versus Open Reduction Internal Fixation in Ankle Fractures
Status: WITHDRAWN
Conditions: Ankle Fractures
Interventions: PROCEDURE: Arthroscopic Assisted Open Reduction Internal Fixation|PROCEDURE: Open Reduction Internal Fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Pain After Bupivacaine Supplementation in Mandibular Fracture Surgery
Status: RECRUITING
Conditions: Postoperative Pain|Mandible Fracture|Analgesia|Anesthesia, Local
Interventions: DRUG: Bupivacain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment Development of Triheptanoin (G1D)
Status: COMPLETED
Conditions: Epilepsy|GLUT1DS1|Glut1 Deficiency Syndrome 1, Autosomal Recessive|Glucose Metabolism Disorders|Glucose Transport Defect|Glucose Transporter Type 1 Deficiency Syndrome|Glucose Transporter Protein Type 1 Deficiency Syndrome
Interventions: DRUG: Triheptanoin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma
Status: RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Zanubrutinib|BIOLOGICAL: Rituximab|OTHER: Patient Observation|PROCEDURE: Bone Marrow Biopsy|OTHER: Fludeoxyglucose F-18|PROCEDURE: Positron Emission Tomography|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Esophagogastroduodenoscopy|PROCEDURE: Colonoscopy|PROCEDURE: Biospecimen Collection|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tirzepatide (LY3298176) in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tirzepatide|DRUG: Tirzepatide|DRUG: Placebo|DRUG: Tirzepatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Double-blind, Double-dummy, Parallel, Active-controlled, Randomized Trial to Evaluate Efficacy & Safety in Anemia Subjects
Status: COMPLETED
Conditions: Iron Deficiency Anemia
Interventions: DRUG: Ferrous (II) Glycine Sulphate Complex|DRUG: Polyferose|OTHER: Placebo to Ferrous (II) Glycine Sulphate Complex|OTHER: Placebo to Polyferose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Adrenal Suppression Potential and Pharmacokinetics of Halobetasol Lotion 0.05%
Status: TERMINATED
Conditions: Plaque Psoriasis
Interventions: DRUG: Halobetasol Topical Lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Periradial Injection of Papaverine Versus Nitroglycerine on Radial Artery Diameter
Status: COMPLETED
Conditions: Radial Artery Injury Prevetion
Interventions: DRUG: papaverine|DRUG: nitroglycerine|DRUG: xlyocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: DBRCT on the Effect of Wheat Polysaccharides on Common Cold Infections in Elderly
Status: COMPLETED
Conditions: Upper Respiratory Infections|Common Cold
Interventions: DIETARY_SUPPLEMENT: wheat polysaccharides|DIETARY_SUPPLEMENT: maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Drug Discrimination in Methadone-Maintained Humans Study 1
Status: COMPLETED
Conditions: Drug Dependence
Interventions: DRUG: Cycloserine|DRUG: Diltiazem|DRUG: Gabapentin|DRUG: Isradipine|DRUG: Naloxone|DRUG: Nifedipine|DRUG: Placebo|DEVICE: Saline|DRUG: Verapamil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: EO2 Oxygen Delivery To Study Success Rate of Surgically Closed Wounds
Status: RECRUITING
Conditions: Surgical Wound|Diabetes|Amputation Wound|Incision Wound|Peripheral Arterial Disease|Breast Cancer|Diabetic Foot
Interventions: DEVICE: Transcu O2®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Music and Other Audio Recordings for Chronic Pain in Aging Adults
Status: COMPLETED
Conditions: Low Back Pain|Chronic Pain|Sleep|Aging
Interventions: BEHAVIORAL: Music with Suggestion|BEHAVIORAL: Pain Information|BEHAVIORAL: Music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy Evaluation of Transperineal Irreversible Electroporation (IRE) of Anterior Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DEVICE: Irreversible Electroporation (IRE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Effect of Vitamin D on the Serum Thioredoxin, TBP-2, Thioredoxin Reductase, Gene Expression of TBP-2 in Patients With Type II Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: vitamin D|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: FR901228 in Treating Children With Refractory or Recurrent Solid Tumors or Leukemia
Status: COMPLETED
Conditions: Blastic Phase Chronic Myelogenous Leukemia|Childhood Central Nervous System Germ Cell Tumor|Childhood Choroid Plexus Tumor|Childhood Chronic Myelogenous Leukemia|Childhood Craniopharyngioma|Childhood Grade I Meningioma|Childhood Grade II Meningioma|Childhood Grade III Meningioma|Childhood High-grade Cerebral Astrocytoma|Childhood Infratentorial Ependymoma|Childhood Low-grade Cerebral Astrocytoma|Childhood Spinal Cord Neoplasm|Childhood Supratentorial Ependymoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Brain Stem Glioma|Recurrent Childhood Cerebellar Astrocytoma|Recurrent Childhood Cerebral Astrocytoma|Recurrent Childhood Ependymoma|Recurrent Childhood Medulloblastoma|Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor|Recurrent Childhood Visual Pathway and Hypothalamic Glioma|Refractory Chronic Lymphocytic Leukemia|Relapsing Chronic Myelogenous Leukemia|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: romidepsin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TPC VS. GP Induced Chemotherapy Combined With Nimotuzumab and Toripalimab in the Treatment of Locally Advanced Nasopharyngeal Carcinoma
Status: NOT_YET_RECRUITING
Conditions: High Risk Locally Advanced Nasopharyngeal Carcinoma
Interventions: DRUG: Nimotuzumab,Toripalimab，Cisplatin, albumin paclitaxel, capecitabine|DRUG: Nimotuzumab,Toripalimab，Cisplatin, Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Diaphragmatic Breathing Exercise on Pain and Sleep Quality in Individuals With Non-specific Chronic Neck Pain: A Randomized Control Trial
Status: COMPLETED
Conditions: Non-specific Chronic Neck Pain|Diaphragmatic Breathing Exercise
Interventions: OTHER: diaphragmatic breathing exercise|OTHER: conventional physiotherapy exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Kiwi on Blood Pressure, Endothelial Function, Antioxidant Capacity and Gene Expression
Status: COMPLETED
Conditions: Hypertension
Interventions: OTHER: Kiwi fruits|OTHER: Apple
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Adaptation to Offset the Interaction Between Ticagrelor and Ritonavir by Population-based PK Modeling
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ticagrelor 180 mg administrated alone|DRUG: Ticagrelor adjusted dose + ritonavir 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: ABC Brain Games Self-Regulation Intervention
Status: COMPLETED
Conditions: Obesity|Self-Regulation
Interventions: BEHAVIORAL: 2. Executive Functioning|BEHAVIORAL: 3. Food Bias|BEHAVIORAL: 4. Emotion Regulation|BEHAVIORAL: 5. Future orientation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Safety, Tolerability, and Pharmacokinetics of E6742 in Systemic Lupus Erythematosus Participants
Status: COMPLETED
Conditions: Lupus Erythematosus, Systemic
Interventions: DRUG: E6742|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Iron Supplementation Versus Routine Iron Intake in Very Low Birth Weight Infants
Status: COMPLETED
Conditions: Iron Deficiency Anemia
Interventions: DIETARY_SUPPLEMENT: Iron Supplement|DIETARY_SUPPLEMENT: multivitamin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Maraviroc Darunavir/Ritonavir Once Daily Pharmacokinetic Study
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Maraviroc|DRUG: Truvada|DRUG: Darunavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Lactibiane Tolérance® in Individuals Suffering From Irritable Bowel Syndrome With Diarrheal Predominance
Status: COMPLETED
Conditions: Diarrhea Predominant Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Lactibiane Tolerance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Exercises for Temporomandibular Disorders
Status: COMPLETED
Conditions: Facial Pain|Temporomandibular Disorder|Temporomandibular Joint Disorders|Temporomandibular; Functional Disturbance
Interventions: OTHER: Physical therapy|OTHER: Appliance therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Dopamine and Serotonin Transporters in Patients With Amyotrophic Lateral Sclerosis and Controls
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: SPECT : 123 I-FP-CIT (DATSCAN) and 123I-ADAM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Crossover of Higher Dose Statins in Patients With Low High-density Lipoproteins Cholesterol (HDLc)
Status: UNKNOWN
Conditions: HDL Cholesterol
Interventions: DRUG: Simvastatin|DRUG: Atorvastatin 80 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Observational Study for Feasibility and Performance of Sub-millisievert Coronary Computed Tomography Angiography (CCTA) for Coronary Artery Anomalies (CAA) in Paediatric Patients
Status: COMPLETED
Conditions: Coronary Artery Anomaly, Congenital
Interventions: DIAGNOSTIC_TEST: coronary angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Metabolic and Cognitive Parameters Following Partial Sleep Deprivation
Status: UNKNOWN
Conditions: Sleep Deprivation|Sleep
Interventions: BEHAVIORAL: Portion Size Task|PROCEDURE: Blood sample|PROCEDURE: Interference task|BEHAVIORAL: Memory tasks|BEHAVIORAL: Intake task|BEHAVIORAL: Working memory function task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: High Intensity Training in Patients With Facioscapulohumeral Muscular Dystrophy
Status: COMPLETED
Conditions: FSHD - Facioscapulohumeral Muscular Dystrophy
Interventions: OTHER: Supervised training|OTHER: Unsupervised training|OTHER: Optional training|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Comparison Between Conventional and Waveform-Confirmed Loss-of-Resistance for Thoracic Epidural Blocks
Status: COMPLETED
Conditions: Anesthesia
Interventions: PROCEDURE: Waveform-confirmed loss-of-resistance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of Biomedical Technology for the Treatment of Ankle Cartilage Using Injectable Biocomposite Hydrogel
Status: RECRUITING
Conditions: Ankle Osteoarthritis
Interventions: PROCEDURE: Injection of biocomposite hydrogel into ankle's cartilage lesion under arthroscopic control|PROCEDURE: Microfracture of ankle's cartilage lesion under arthroscopic control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First-in-Human Study of D-0502 Alone and in Combination With Palbociclib in Women With Advanced or Metastatic ER-Positive and HER2-Negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: D-0502|DRUG: palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Evaluate the Effects of Subcutaneously Administered Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor in Pediatric HIV-Infected Patients With Neutropenia Secondary to Azidothymidine
Status: COMPLETED
Conditions: HIV Infections|Cytopenias
Interventions: DRUG: Zidovudine|DRUG: Sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Study of IBI310 in Combination With IBI308 Compared to High-Dose Interferon In Patients With Acral Melanoma That Has Been Removed by Surgery
Status: TERMINATED
Conditions: Acral Melanoma That Has Been Removed by Surgery
Interventions: DRUG: IBI310+IBI308|DRUG: IBI308|DRUG: High-dose recombinant interferon a-2B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study to Evaluate the Safety and Effectiveness of MK0686 for the Treatment of Postherpetic Neuralgia (Also Known as PHN or Post Shingles Pain) (0686-005)
Status: TERMINATED
Conditions: Neuralgia, Postherpetic
Interventions: DRUG: MK0686
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Video-assisted Breastfeeding Education Given to Mothers of Hospitalized Newborns on Breastfeeding
Status: COMPLETED
Conditions: Breastfeeding|Intensive Care Units|Neonatal
Interventions: BEHAVIORAL: Video-assisted breastfeeding training|BEHAVIORAL: The hospital's routine general breastfeeding training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Laser Therapy in Women With Lichenoid Disorders
Status: RECRUITING
Conditions: Lichen Sclerosus Et Atrophicus|Lichen Planus
Interventions: DEVICE: Laser|DEVICE: Placebolaser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Decoding Motor Imagery From Non-invasive Brain Recordings as a Prerequisite for Innovative Motor Rehabilitation Therapies
Status: NOT_YET_RECRUITING
Conditions: Upper Limb Deficit After Stroke|Motor Imagery
Interventions: DEVICE: MRI|DEVICE: MEG|DEVICE: EEG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Biological Therapy in Treating Patients at High-Risk or With Lymphoma, Lymphoproliferative Disease, or Malignancies
Status: COMPLETED
Conditions: EBV-induced Lymphomas|EBV-associated Malignancies|Transplant Patients With EBV Viremia at High Risk of Developing a Recurrent EBV Lymphoma
Interventions: BIOLOGICAL: Epstein-Barr virus-specific cytotoxic T lymphocytes (EBV-CTLs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Use of Lanreotide Autogel® 120 mg in Patients With Locally Advanced or Metastatic Gastroenteropancreatic Neuroendocrine Tumours (GEP-NETs) in Routine Clinical Practice
Status: WITHDRAWN
Conditions: Neuroendocrine Tumors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ABX464 in Fully Controlled HIV Infected Patients Treated With Boosted Protease Inhibitor Treatment
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: ABX464|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Exercise on Mitigating the Cardio-toxic Effects of Adriamycin Among Women Newly Diagnosed With Breast Cancer.
Status: COMPLETED
Conditions: Breast Cancer Female|Adriamycin Toxicity
Interventions: BEHAVIORAL: 10,000 steps|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Self-Management and Resourceful Transition of Type 2 Diabetes With Stage 3 Kidney Disease
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2|Renal Insufficiency, Chronic
Interventions: BEHAVIORAL: Computer assisted education and motivational interviewing.|BEHAVIORAL: Group talks/social chat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT