pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Preventing Staphylococcal (Staph) Infection
Status: COMPLETED
Conditions: Staphylococcal Infections
Interventions: DRUG: Mupirocin Ointment [Treatment]|DRUG: Polyethylene Glycol Ointment [Placebo]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: FUNctional eFficacy of Hybrid coronAry REvascularization
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Hybrid coronary revascularization|PROCEDURE: Coronary artery bypass grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Thickened Feeds on Clinical Outcomes in Children With Brief Resolved Unexplained Event
Status: RECRUITING
Conditions: Brief Resolved Unexplained Event|Apparent Life Threatening Event|Oropharyngeal Dysphagia
Interventions: DIETARY_SUPPLEMENT: Thickened feeds|DIETARY_SUPPLEMENT: Non-thickened feeds
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Counteracting Age-related Loss of Skeletal Muscle Mass
Status: COMPLETED
Conditions: Sarcopenia|Muscle Loss
Interventions: PROCEDURE: Heavy Resistance Training|PROCEDURE: Light Intensity Training|DIETARY_SUPPLEMENT: Protein Whey|DIETARY_SUPPLEMENT: Protein Collagen|DIETARY_SUPPLEMENT: Carbohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of GIP After a Meal in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type2 Diabetes
Interventions: OTHER: GIP(3-30)NH2|OTHER: Peripheral venous cannulation|OTHER: GLP-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Inhibition Transcranial Random Noise Stimulation
Status: COMPLETED
Conditions: Impulsive Behavior|Inhibition
Interventions: DEVICE: transcranial random noise stimulation (tRNS) (Starstim)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intravenous Infusion for Autism
Status: RECRUITING
Conditions: Autism
Interventions: BIOLOGICAL: AlloRx
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: THE EFFECT OF LABOR DANCE ON THE LABOR PAIN, BIRTH SATISFACTION AND NEONATAL OUTCOMES
Status: COMPLETED
Conditions: Labor Pain|Satisfaction|Infant Conditions
Interventions: BEHAVIORAL: Labor Dance
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trimodality Management of T1b Esophageal Cancers
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: Docetaxel|DRUG: 5-FU|RADIATION: Radiotherapy|PROCEDURE: Esophagectomy|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Daratumumab or FMS Inhibitor JNJ-40346527 Before Surgery in Treating Patients With High-Risk, Resectable Localized or Locally Advanced Prostate Cancer
Status: COMPLETED
Conditions: Prostate Adenocarcinoma|Stage III Prostate Cancer AJCC v8|Stage IIIA Prostate Cancer AJCC v8|Stage IIIB Prostate Cancer AJCC v8|Stage IIIC Prostate Cancer AJCC v8|Testosterone Greater Than 150 ng/dL
Interventions: BIOLOGICAL: Daratumumab|DRUG: FMS Inhibitor JNJ-40346527|PROCEDURE: Radical Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Levetiracetam in Early Psychosis
Status: COMPLETED
Conditions: Psychosis|Schizophrenia|Schizo Affective Disorder|Schizophreniform
Interventions: DRUG: Levetiracetam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Randomized Controlled Trial Evaluating One Drop | Premium With Afrezza vs. One Drop | Premium Alone
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Afrezza plus One Drop | Premium|OTHER: One Drop | Premium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerance of a Motorized Orthosis Reproducing Walking Movement vs Conventional Standing-up Devices in Child With CP
Status: COMPLETED
Conditions: CP (Cerebral Palsy)
Interventions: DEVICE: PC Innowalk|DEVICE: Conventional passive stander
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Horizontal Ridge Augmentation Using Equine Xenograft and a Collagenated Porcine Cortical Lamina
Status: COMPLETED
Conditions: Horizontal Ridge Deficiency
Interventions: DEVICE: Gen-Os®; The soft lamina (OsteoBiol®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial of Laparoscopic Nissen Fundoplication Treatment of Patients With Chronic GERD
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DRUG: Proton Pump Inhibitors|PROCEDURE: Laparoscopic Nissen Fundoplication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of MGL-3196 in Patients With Non-Alcoholic Steatohepatitis (NASH)
Status: UNKNOWN
Conditions: Non-alcoholic Steatohepatitis
Interventions: DRUG: MGL-3196|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PeRioperative Optimization With Nutritional Supplements for Patients Undergoing GastRointEStinal Surgery for Cancer
Status: COMPLETED
Conditions: Gastrointestinal Cancer
Interventions: OTHER: Nutritional Supplements|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fasting Study of Nadolol/Bendroflumethiazide Tablets 80 mg/5 mg and Corzide® Tablets 80 mg/5 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Nadolol/Bendroflumethiazide Tablets 80 mg/5 mg|DRUG: Corzide® Tablets 80 mg/5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Strategies for Hepatitis C Testing and Treatment in Aboriginal Communities That Lead to Elimination
Status: UNKNOWN
Conditions: Hepatitis C|Hepatitis|Liver Diseases|Hepatitis, Viral, Human|RNA Virus Infections|Digestive System Diseases
Interventions: DEVICE: Fingerstick GeneXpert HCV RNA quantitative assay|DRUG: sofosbuvir/velpatesvir|DRUG: glecaprevir/pibrentasvir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Extremely Low Magnetic Field (ELF) in Fibromyalgic Patients
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: LIMFA Therapy®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Multicenter Study to Evaluate the Effects of a 91-day Oral Contraceptive on Bone Mineral Density in Adolescent Females
Status: COMPLETED
Conditions: Bone Mineral Density
Interventions: DRUG: 91-day Levonorgestrel Oral Contraceptive|DRUG: 28-day Levonorgestrel Oral Contraceptive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Warmer Temperature Decrease Propofol Injection Pain
Status: UNKNOWN
Conditions: Injection Site Irritation|Propofol Syndrome|Temperature Change, Body
Interventions: BEHAVIORAL: warmer temperature
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Primary Prevention and Uterine Preservation in Premenopausal Women With Obesity and Endometrial Hyperplasia
Status: NOT_YET_RECRUITING
Conditions: Endometrial Hyperplasia
Interventions: DRUG: Semaglutide|DRUG: Placebo|DRUG: LNG-IUD (Progestin)|BEHAVIORAL: Telemedicine behavioral weight program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Internet-based Rehabilitation Aftercare Focusing on Physical Activity Promotion in Persons With COPD
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: Pulmonary Rehabilitation (usual care)|OTHER: Pulmonary Rehabilitation (usual care) + familiarization with components of the aftercare program|OTHER: After care: Exercise and physical activity promotion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microbiome Modification to Enhance Stelara Response in Crohn's Disease
Status: WITHDRAWN
Conditions: Crohn Disease
Interventions: DIETARY_SUPPLEMENT: Low serine diet|DIETARY_SUPPLEMENT: High serine diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Inactivated Influenza A/H5N1 Vaccine in Adult Subjects at Risk of Occupational Exposure to Live H5N1 Viruses
Status: UNKNOWN
Conditions: Influenza
Interventions: BIOLOGICAL: inactivated influenza A/H5N1 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vestibular Function Using Mitochondrial Antioxidant Therapy
Status: WITHDRAWN
Conditions: Vestibular Function Disorder
Interventions: DRUG: Alpha Lipoic Acid 300mg|DRUG: Coenzyme Q10 200mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Epalrestat Therapy in Pediatric Subjects With PMM2-CDG
Status: ACTIVE_NOT_RECRUITING
Conditions: Pmm2-CDG|Phosphomannomutase 2 Deficiency|Phosphomannomutase 2 Congenital Disorder of Glycosylation|Phosphomannomutase II Congenital Disorder of Glycosylation|Phosphomannomutase II Deficiency
Interventions: DRUG: Epalrestat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanisms Underlying Psychosocial Associations With Ischemic Heart Disease (Kuopio)
Status: COMPLETED
Conditions: Cardiovascular Diseases|Carotid Artery Diseases|Arrhythmia|Myocardial Ischemia|Thrombosis|Heart Diseases|Atherosclerosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bilateral Quadraus LUMBORUM Block in Patients Under Going Cystectomy
Status: UNKNOWN
Conditions: Pain, Acute
Interventions: PROCEDURE: epidural catheter|PROCEDURE: nerve block catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Absolute Bioavailability and Mass Balance of CHF6001 (Tanimilast) in Healthy Subjects
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)|COPD
Interventions: DRUG: CHF6001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: 2. Study to Evaluate the Efficacy/Safety of Bremelanotide in Premenopausal Women With Hypoactive Sexual Desire Disorder
Status: COMPLETED
Conditions: Hypoactive Sexual Desire Disorder
Interventions: DRUG: Bremelanotide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Uniport and Multiport Epidural Catheters in Post-surgical Patients
Status: COMPLETED
Conditions: Post-operative Pain
Interventions: DEVICE: Epidural catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Monoclonal Antibodies for Early Etiotropic Therapy for Coronavirus Infection Caused by the SARS-CoV-2 Virus
Status: NOT_YET_RECRUITING
Conditions: COVID-19
Interventions: DRUG: GamCoviMab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nesvacumab (REGN910/ SAR307746) and Aflibercept ("Ziv-aflibercept" in the U.S.) in Patients With Advanced Solid Malignancies
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: nesvacumab (REGN910/ SAR307746)|DRUG: nesvacumab (REGN910/ SAR307746)|DRUG: nesvacumab (REGN910/ SAR307746)|DRUG: aflibercept (ziv-aflibercept)|DRUG: aflibercept (ziv-aflibercept)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single and Low Dose of Recombinant Factor VIIa in Patients With Severe Factor XI Deficiency Undergoing Surgery
Status: UNKNOWN
Conditions: Hemophilia C
Interventions: DRUG: recombinant factor VIIa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antimicrobial Effect of Modified Antibiotic Nanofibers for Regenerative Endodontics Procedures
Status: UNKNOWN
Conditions: Necrosis, Pulp
Interventions: PROCEDURE: electrospun TAP nanofibers|PROCEDURE: modified TAP paste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotics on ADHD
Status: COMPLETED
Conditions: ADHD|Probiotics|Gut Microbiota|Psychiatry|Clinical Trial
Interventions: DRUG: Placebo|OTHER: BF688
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bilateral or Unilateral Cerebellar Deep Brain Stimulation for Chronic Post-stroke Motor Rehabilitation
Status: RECRUITING
Conditions: Stroke
Interventions: DEVICE: Bilateral Cerebellar deep brain stimulation|DEVICE: Unilateral Cerebellar deep brain stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenocity and Safety of Flubio (Influenza HA) Vaccine in Infants and Children (Bridging Study)
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tenecteplase in Wake-up Ischaemic Stroke Trial
Status: UNKNOWN
Conditions: Ischemic Stroke|Stroke, Acute
Interventions: DRUG: Tenecteplase|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nicotinic Receptor Genetic Variation and Alcohol Reward
Status: RECRUITING
Conditions: Alcohol Drinking
Interventions: DRUG: Alcohol (Oral)|DRUG: Alcohol (IV)|DRUG: Alcohol (Ethanol)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of New Flexible High-density Intra-operative ECoG Electrodes for Epilepsy Surgery. ( EpiGrid )
Status: NOT_YET_RECRUITING
Conditions: Focal Epilepsy|Intraoperative Monitoring
Interventions: DEVICE: SOFT ECoG subdural grid electrode
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of APD811 in Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: APD811|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Navigated Versus Convention Total Knee Arthroplasty
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Knee|Surgery, Computer-Assisted
Interventions: DEVICE: Electromagnetically navigated total knee arthroplasty|DEVICE: Conventional total knee arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Estetrol (E4)/Drospirenone (DRSP) Drug-drug Interaction (DDI) Study
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: E4/DRSP|DRUG: VAL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study of IRL790 in Patients With Parkinson's Disease Experiencing Levodopa Induced Dyskinesia
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: IRL790|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HM2014-26 DT2219 for Relapsed or Refractory B-Lineage Leukemia or Lymphoma
Status: COMPLETED
Conditions: Refractory B-Lineage Leukemia|Relapsed B-Lineage Leukemia|Refractory B-Lineage Lymphoma|Relapsed B-Lineage Lymphoma
Interventions: BIOLOGICAL: DT2219ARL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flaxseed, Aromatase Inhibitors and Breast Tumor Characteristics
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Anastrozole|DIETARY_SUPPLEMENT: flaxseed|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Extension Study to Evaluate the Safety of Q8003 in Patients With Acute Moderate to Severe Pain
Status: COMPLETED
Conditions: Acute Moderate to Severe Pain
Interventions: DRUG: Q8003|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of "First-Line" Rhythm Therapy on AF Progression
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Cryoballoon-based PVI|DRUG: Anti-Arrhythmic Drug Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Very Brief Intervention to Increase the Intention to Practice Physical Activity
Status: NOT_YET_RECRUITING
Conditions: Physical Activity
Interventions: DEVICE: Intervention: motion-sensor video game|DEVICE: Placebo: mobile APP game (without motion-sensoring)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: BABE(Body Appreciation and Better Eating), Add Some Self-compassion
Status: ACTIVE_NOT_RECRUITING
Conditions: Body Image|Eating Behavior|Binge Eating|Nutrition, Healthy|Disordered Eating
Interventions: BEHAVIORAL: BABE (Body Appreciation and Better Eating)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Seek, Test, and Retain. Linkages for Black HIV+, Substance-Using MSM
Status: COMPLETED
Conditions: Substance Abuse|Sexual Behavior
Interventions: BEHAVIORAL: Patient Navigation (PN) Intervention|BEHAVIORAL: Financial Incentives (FI) Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Suprathel® Use During Prolonged Field Care to Promote Healing and Reduce the Need for Grafting of Burn Wounds
Status: NOT_YET_RECRUITING
Conditions: Wound of Skin|Burns
Interventions: OTHER: Suprathel®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Bilateral RSB on Postoperative Delirium in Elderly Patients Undergoing Laparoendoscopic Single-site Surgery
Status: UNKNOWN
Conditions: Delirium in Old Age|Hernia, Inguinal|Cholecystolithiasis
Interventions: PROCEDURE: ultrasound-guided bilateral rectus sheath block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Signal Propagation and Its Relationship to Cognitive Performance in the Aging Human Brain (Focus or Spread)
Status: COMPLETED
Conditions: Healthy Aging
Interventions: DEVICE: single-puls TMS|DEVICE: sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Postoperative Radiotherapy for Atypical Meningioma Without Venous Sinus Invasion After Gross-total Resection
Status: NOT_YET_RECRUITING
Conditions: Meningioma Atypical|Radiotherapy|Progression-Free Survival|Adverse Effect of Radiation Therapy
Interventions: RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Heparin-based Wet Suction Method in EUS Fine Needle Biopsy of Solid Pancreatic Mass
Status: UNKNOWN
Conditions: Endoscopic Ultrasonography|EUS-FNA|Pancreatic Neoplasms
Interventions: PROCEDURE: EUS fine needle biopsy with heparin wet suction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: CRT In Narrow QRS Heart Failure: Mechanistic Insights From Cardiac MRI And Electroanatomical Mapping
Status: TERMINATED
Conditions: Heart Failure
Interventions: PROCEDURE: Temporary pacing study|RADIATION: Body Surface Mapping
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of the Programme Developed for Sedentary Elderly in the COVID-19 Pandemic: Mobile Interventional Study
Status: COMPLETED
Conditions: Aged
Interventions: BEHAVIORAL: "Stay at Home Take a Step Program (SHTSP)"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Electrothermal Arthroscopic Capsulorrhaphy (ETAC) and Open Inferior Capsular Shift in Patients With Shoulder Instability
Status: COMPLETED
Conditions: Shoulder Dislocation
Interventions: PROCEDURE: Electrothermal arthroscopic capsulorrhaphy (ETAC)|PROCEDURE: Open inferior capsular shift (ICS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Single and Repeated Doses of Glucagon Administered to Participants With Diabetes
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DRUG: Nasal Glucagon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Telephone-Based Intervention in Increasing Adherence to Adjuvant Hormonal Therapy in Patients With Breast Cancer
Status: RECRUITING
Conditions: Stage IA Breast Cancer|Stage IB Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage 0 Breast Cancer
Interventions: BEHAVIORAL: Telephone-Based Intervention|OTHER: Survey Administration|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Soy Treatment Evaluation for Metabolic Health (STEM) Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Metabolic Syndrome|Overweight and Obesity|PreDiabetes|Diabetes|Healthy Obesity, Metabolically|Overweight|Obesity|Dysglycemia|Cardiovascular Diseases|Heart Disease Risk Factors|Hypertension|Dyslipidemias
Interventions: OTHER: Soy Milk|OTHER: Cow's Milk|OTHER: Sugar Sweetened Beverages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Exercise and Low-Dose Rapamycin in Older Adults With CAD:Cardiac Rehabilitation And Rapamycin in Elderly (CARE) Trial
Status: COMPLETED
Conditions: Aging|CAD
Interventions: DRUG: Rapamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 2 Courses of Concurrent Cisplatin Chemoradiotherapy After Surgery for High-risk Head and Neck Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Squamous Cell Carcinoma of Head and Neck
Interventions: DRUG: Drug：Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Reactogenicity of DTPa-HBV-IPV/Hib Vaccine Followed by the Same Vaccine and Oral Polio Vaccine
Status: COMPLETED
Conditions: Hepatitis B|Acellular Pertussis|Haemophilus Influenzae Type b|Diphtheria|Tetanus|Poliomyelitis
Interventions: BIOLOGICAL: DTPa-HBV-IPV/Hib (Infanrix hexa™)|BIOLOGICAL: OPV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Project Phakama: Testing Support Strategies to Empower Young Women on PrEP in South Africa
Status: RECRUITING
Conditions: Pre-exposure Prophylaxis|HIV Infections
Interventions: BEHAVIORAL: Case management|BEHAVIORAL: Food vouchers|BEHAVIORAL: PrEP support buddy|BEHAVIORAL: Community-based PrEP pickup points
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Digital Support for Mental Health Intervention in Patients With Inflammatory Bowel Disease
Status: NOT_YET_RECRUITING
Conditions: Inflammatory Bowel Diseases|Anxiety|Depression|Ulcerative Colitis|Crohn Disease
Interventions: BEHAVIORAL: Mental health support session
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Open Label Study to Collect Clinical Data to Document Clinical Performance and Safety in Total Knee Arthroplasty
Status: TERMINATED
Conditions: Total Knee Arthroplasty|Knee Disease|Total Knee Replacement|Osteo Arthritis Knee
Interventions: DEVICE: patient with knee arthroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Probiotics on Type 1 Diabetes Mellitus in Children
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: OTHER: L. johnsonii MH-68, B. animalis subsp. lactis CP-9 and L. salivarius AP-32|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Time-Limited Approach to Treatment With Ibrutinib for Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
Status: WITHDRAWN
Conditions: CLL|SLL|CLL/SLL|Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: OTHER: Treatment Free Observation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Early Functional Outcomes in Unisplaced Neck of Femur Fracture Treated With Partially Threaded and Fully Threaded Cannulated Screw Fixation in Patients of Age 60 and Above
Status: COMPLETED
Conditions: Neck of Femur Fracture
Interventions: PROCEDURE: Fully threaded cannulated screws
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placement Of Cardiac PacemaKer Trial (POCKET)-RCT
Status: UNKNOWN
Conditions: Pacemaker Ddd
Interventions: DEVICE: subcutaneous pacemaker|DEVICE: intramuscular pacemaker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Tamadol Wound Infiltration in Children Under Inguinal Hernioplasty
Status: COMPLETED
Conditions: Children|Inguinal Hernia
Interventions: DRUG: tramadol|DRUG: 0.9% saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Preoperative Diclofenac Potassium on Postoperative Endodontic Pain
Status: COMPLETED
Conditions: Pulpitis - Irreversible
Interventions: DRUG: Diclofenac Potassium 50mg Tab.|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ba Duan Jin in Treatment of Attention Deficit Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: Baduanjin practice|BEHAVIORAL: Regular physical exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Pumpkin Seed Oil Supplementation on Cardiovascular Function in Postmenopausal Women.
Status: COMPLETED
Conditions: Elevated Blood Pressure|Hypertension
Interventions: OTHER: Pumpkin Seed Oil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intravitreal Aflibercept Injection for Radiation Retinopathy
Status: COMPLETED
Conditions: Radiation Retinopathy|Macular Edema
Interventions: DRUG: Aflibercept every 2 months|DRUG: Aflibercept monthly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: AAT + tDCS to Reduce Cue-induced Craving and Smoking Behavior
Status: COMPLETED
Conditions: Smoking Behaviors|Smoking, Cigarette
Interventions: BEHAVIORAL: Approach/Avoidance Task|DEVICE: Transcranial Direct Current Stimulation|BEHAVIORAL: AC|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of a Booster Vaccination With a Non-Adjuvanted H5N1 Influenza Vaccine (Follow Up to Study 810501)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: H5N1 influenza vaccine (whole virion, Vero cell-derived), 7.5 µg HA antigen, non-adjuvanted
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Periorbital and Perioral Wrinkles With the Applications of the Iluminage Diode Laser
Status: COMPLETED
Conditions: Peri-orbital Wrinkles|Peri-oral Wrinkles
Interventions: DEVICE: Illuiminage ® Diode Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Systems Approach to Immunotherapy Biomarker Identification Within the Postoperative Wound-Healing Microenvironment in Patients With Gastroesophageal Cancer
Status: RECRUITING
Conditions: GastroEsophageal Cancer
Interventions: OTHER: prospective collection of surgical exudates (SEs)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase III Trial of Gemcitabine, Curcumin and Celebrex in Patients With Advance or Inoperable Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Curcumin|DRUG: Celebrex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: Decitabine and Clofarabine in Higher Risk Myelodysplastic Syndromes (MDS)
Status: COMPLETED
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: Decitabine|DRUG: Clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes of Operative Treatment of Unstable Ankle Fracture - Comparison Between Metallic and Biodegradable Implants
Status: COMPLETED
Conditions: Ankle Fracture
Interventions: DEVICE: fixation of the ankle fracture (Solco )|DEVICE: fixation of the ankle fracture (Freedom)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of AWZ1066S, a Small Molecule Anti-Wolbachia Candidate Macrofilaricide Drug
Status: TERMINATED
Conditions: Filariasis, Lymphatic|Onchocerciasis
Interventions: DRUG: AWZ1066S|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety of Administering Ocrelizumab Per a Shorter Infusion Protocol in Participants With Primary Progressive Multiple Sclerosis (PPMS) and Relapsing Multiple Sclerosis (RMS)
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Ocrelizumab Dose 1|DRUG: Ocrelizumab Dose 2 and Dose 3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination Versus Insulin Glargine in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Insulin glargine/lixisenatide (HOE901/AVE0010)|DRUG: Insulin glargine (HOE901)|DRUG: Metformin (Background Drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementing Alcohol Misuse SBIRT in a National Cohort of Pediatric Trauma Centers
Status: ACTIVE_NOT_RECRUITING
Conditions: Alcohol Drinking
Interventions: OTHER: SSL Implementation Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Remote Programming of Cardiac Implantable Electronic Device
Status: COMPLETED
Conditions: Defibrillators, Implantable|Follow-Up Studies|Pacemaker, Artificial|Telemedicine|Algorithms
Interventions: OTHER: Interrogation/programming
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison by Transoesophageal Assessement of Systolic Right Ventricle Function Measures in Perioperative Care of Pulmonary Transplant.
Status: COMPLETED
Conditions: Primary Lung Graft Dysfunction
Interventions: PROCEDURE: transoesophageal echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Proof of Concept Study Evaluating BP1.3656 in Patients With Fatigue Following Ischemic Stroke
Status: TERMINATED
Conditions: Fatigue
Interventions: DRUG: BP1.3656
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evalution of Immunogenicity, Safety and Booster Response of a Rabies Vaccine Administered Concomitantly With Japanese Encephalitis Vaccine in Toddlers
Status: COMPLETED
Conditions: Rabies|Japanese Encephalitis|Pre-Exposure Prophylaxis
Interventions: BIOLOGICAL: Three 1 mL doses of Rabies vaccine and two JE vaccine|BIOLOGICAL: Three 0.5 mL doses of Rabies vaccine and two JE vaccine|BIOLOGICAL: Three 0.1mL doses of Rabies Vaccine and two JE vaccine|BIOLOGICAL: Two 0.1mL doses of Rabies vaccine and two JE vaccine|BIOLOGICAL: Two doses of JE vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of High Monounsaturated Fat Diet on Glycemic Control and Cardiovascular Risk Factors in Type 2 Diabetes
Status: COMPLETED
Conditions: Overweight|Obesity|Type 2 Diabetes
Interventions: OTHER: High-MUFA diet|OTHER: High-CHO diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: S0916, MLN1202 in Treating Patients With Bone Metastases
Status: COMPLETED
Conditions: Metastatic Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: anti-CCR2 monoclonal antibody MLN1202|GENETIC: polymorphism analysis|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GPx Activity in Subjects With Aortic Stenosis Undergoing TAVR
Status: WITHDRAWN
Conditions: Glutathione Peroxidase Activity|Aortic Stenosis|Transcatheter Aortic Valve Replacement
Interventions: DIAGNOSTIC_TEST: Blood draw to measure GPx activity|DIAGNOSTIC_TEST: Blood draw to measure SOD activity|DIAGNOSTIC_TEST: Blood draw to measure Lp(a) levels
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Evaluation of the Lenstec SBL-3 Multifocal Intraocular Lens
Status: COMPLETED
Conditions: Cataracts|Presbyopia
Interventions: DEVICE: SBL-3 multifocal intraocular lens|DEVICE: Control monofocal intraocular lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacological Comparison of Continuous and Intermittent Infusions of Cloxacillin
Status: COMPLETED
Conditions: Infection|Methicillin Susceptible Staphylococcus Aureus Infection|Cloxacillin Treatment
Interventions: DRUG: Modification for administration mode of cloxacillin antibiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mucorales PCR Screening in At-risk Hematology Patients
Status: RECRUITING
Conditions: Mucormycosis
Interventions: DIAGNOSTIC_TEST: Mucorales PCR (MucorGenius, PathoNostics, Maastricht, The Netherlands)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study of Taspoglutide in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: Placebo|DRUG: taspoglutide|DRUG: taspoglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Topical Cantharidin for the Treatment of Molluscum Contagiosum
Status: COMPLETED
Conditions: Molluscum Contagiosum
Interventions: DRUG: Cantharidin|DRUG: Placebo|DEVICE: Gauze occlusion bandage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 64Cu-SAR-BBN and 67CU SAR-BBN for Identification and Treatment of Gastrin Releasing Peptide Receptor (GRPR)-Expressing Metastatic Castrate Resistant Prostate Cancer in Patients Who Are Ineligible for Therapy With 177Lu-PSMA-617 (COMBAT)
Status: RECRUITING
Conditions: Prostatic Neoplasms|Castration-Resistant
Interventions: DRUG: 64Cu-SAR-BBN|DRUG: 67Cu-SAR-BBN
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of PN400 (VIMOVO) Twice Daily and Celebrex Once Daily in Patients With Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: PN 400 (VIMOVO)|DRUG: celebrex|DRUG: Placebo|DRUG: Rescue Antacid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Spinal Analgesia as Fast Track Painless Labor
Status: COMPLETED
Conditions: Labor Pain|Pain, Postoperative|Pain, Acute
Interventions: PROCEDURE: Single-shot spinal analgesia|PROCEDURE: Continuous epidural analgesia|PROCEDURE: Combined spinal-epidural analgesia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ESSENCE Study: Efficacy and Safety of SD-101 Cream in Participants With Epidermolysis Bullosa
Status: COMPLETED
Conditions: Epidermolysis Bullosa
Interventions: DRUG: SD-101-6.0 cream|DRUG: Placebo (SD-101-0.0) cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chocolate Consumption in Healthy Pregnant Women Trial
Status: COMPLETED
Conditions: Hypertension Pregnancy-induced
Interventions: OTHER: Flavanol-rich dark chocolate|OTHER: Placebo Chocolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: US Phase III Study of APD421 in PONV
Status: COMPLETED
Conditions: PONV
Interventions: DRUG: APD421- Amisulpride for IV injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical and Medico-economic Evaluation of Taken Care Associating Nutritional Support and Adapted Physical Activity for Malnourished, or at Risk of Undernutrition, Elderly People on Discharge From Hospital
Status: TERMINATED
Conditions: Under-nutrition or Risk of Undernutrition
Interventions: OTHER: Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of AV-stimulation in Immersive VR to Improve Visual Perception and Driving Performance
Status: NOT_YET_RECRUITING
Conditions: Stroke|Visual Impairment|Low Vision|Virtual Reality|Visual Spatial Processing|Visual Field Defect|Visual Processing Speed|Cognitive Impairment|Driving Impaired
Interventions: DEVICE: Audiovisual Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Assess the Effect on Glucose Homeostasis of Two Dose Levels of AZD9567, Compared to Prednisolone, in Adults With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: AZD9567|DRUG: Prednisolone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Dietary Fiber on the Gut Microbiome and HDL Particles of Human Subjects
Status: COMPLETED
Conditions: Gut Microbiota
Interventions: OTHER: Dietary Fiber|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sargramostim and Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Advanced Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer That Did Not Respond to Previous Chemotherapy
Status: COMPLETED
Conditions: Brenner Tumor|Fallopian Tube Cancer|Ovarian Clear Cell Cystadenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian Mixed Epithelial Carcinoma|Ovarian Mucinous Cystadenocarcinoma|Ovarian Serous Cystadenocarcinoma|Ovarian Undifferentiated Adenocarcinoma|Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer|Stage III Ovarian Epithelial Cancer|Stage IV Ovarian Epithelial Cancer
Interventions: BIOLOGICAL: sargramostim|DRUG: paclitaxel albumin-stabilized nanoparticle formulation|OTHER: laboratory biomarker analysis|OTHER: immunologic technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dextromethorphan Effect on Central Sensitization to Pain in Healthy Volunteers
Status: COMPLETED
Conditions: Experimental Pain|Hyperalgesia
Interventions: DRUG: Pulmodexane® 30mg|DRUG: lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) in Subjects With Dim Light Vision Disturbances
Status: COMPLETED
Conditions: Dim Light Vision Disturbances
Interventions: DRUG: Phentolamine Ophthalmic Solution 0.75%|DRUG: Phentolamine Ophthalmic Solution Vehicle (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of 13C Methacetin Breath Test in Predicting Prognosis Among Patients With Acute or Acute on Chronic Liver Failure (ACLF).
Status: COMPLETED
Conditions: Acute Liver Failure|Acute on Chronic Liver Failure
Interventions: DEVICE: Methacetin Breath Test in ACLF and ALF patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Preliminary Safety and Effectiveness of SMI-01 as a Tissue Filler
Status: COMPLETED
Conditions: Nasolabial Fold|Cheek Augmentation
Interventions: DEVICE: SMI-01
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY