pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Friendship Bench Adaptation to Improve Mental Health & HIV Care Engagement Outcomes Among PLWH and PWID in Vietnam
Status: COMPLETED
Conditions: HIV Infections|Behavioral Symptoms|Depression|Anxiety|Opioid-use Disorder|Virus Infection|Immune System Diseases|Opioid Dependence
Interventions: BEHAVIORAL: Friendship Bench Delivered by Professional Counselor|BEHAVIORAL: Friendship Bench Delivered by Lay Counselor|BEHAVIORAL: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of HDC/IL-2 Treatment in Chronic Myelomonocytic Leukemia (CMML)
Status: UNKNOWN
Conditions: Leukemia, Myelomonocytic, Chronic
Interventions: DRUG: Cohort 1, Ceplene® and Proleukin®|DRUG: Cohort 2, Ceplene® and Proleukin®|DRUG: Cohort 3, Ceplene® and Proleukin®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Dose Study of GRN163L and Velcade to Treat Patients With Refractory or Relapsed Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Imetelstat Sodium (GRN163L)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Biomarkers in Blood and Tissue Samples From Patients With Epstein-Barr Virus-Positive Hodgkin Lymphoma
Status: COMPLETED
Conditions: Lymphoma|Nonneoplastic Condition
Interventions: GENETIC: DNA analysis|GENETIC: RNA analysis|GENETIC: cytogenetic analysis|GENETIC: in situ hybridization|GENETIC: mutation analysis|GENETIC: polymerase chain reaction|GENETIC: western blotting|OTHER: flow cytometry|OTHER: immunohistochemistry staining method|OTHER: medical chart review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Efficacy and Safety of PF-06700841 in Subjects With Active Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: PF-06700841|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single-dose Intravenous Iron Therapy for Anemia After Orthopaedic Trauma
Status: RECRUITING
Conditions: Acute Blood Loss Anemia|Fracture
Interventions: DRUG: Iron-Dextran Complex Injection [InFed]|OTHER: Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Corneal Wavefront-guided TPRK and ACXL Following ICRS Implantation in Management of Moderate Keratoconus
Status: COMPLETED
Conditions: Keratoconus
Interventions: PROCEDURE: Intracorneal ring segment implantaion as the first stage|PROCEDURE: ACXL and wafe front guieded TPRK as the second stage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Supraclavicular Block for Arthroscopic Shoulder Surgery
Status: COMPLETED
Conditions: Horner's Syndrome
Interventions: OTHER: Supraclavicular block|OTHER: Interscalene block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: PCT-guided Treatment Regarding Antibiotic Use for Acute COPD Exacerbations
Status: RECRUITING
Conditions: COPD Exacerbation|COPD|Acute Copd Exacerbation
Interventions: DIAGNOSTIC_TEST: Procalcitonin|OTHER: Physician's decision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Intraperitoneal Chemotherapy Alone or in Combination With Bevacizumab for Ovarian Cancer With Peritoneal Adhesion
Status: UNKNOWN
Conditions: Peritoneal Adhesion
Interventions: DRUG: Bevacizumab|DRUG: Carboplatin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 5-Alpha Reductase and Anabolic Effects of Testosterone
Status: COMPLETED
Conditions: Male Hypogonadism|Muscle Atrophy|Sarcopenia|Benign Prostate Hypertrophy
Interventions: DRUG: Testosterone Enanthate|DRUG: Finasteride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Cediranib in the Treatment of Patients With Alveolar Soft Part Sarcoma (CASPS)
Status: UNKNOWN
Conditions: Alveolar Soft-part Sarcoma
Interventions: DRUG: Cediranib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus
Status: UNKNOWN
Conditions: Atrophic Oral Lichen Planus|Erosive Oral Lichen Planus
Interventions: DRUG: placebo|DRUG: Quercetin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Best EGFR-TKI Sequence in NSCLC Harboring EGFR Mutations
Status: RECRUITING
Conditions: NSCLC
Interventions: DRUG: Osimertinib|DRUG: Dacomitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Nitric Oxide to Prevent and Treat Bronchopulmonary Dysplasia
Status: COMPLETED
Conditions: Pulmonary Disease
Interventions: DRUG: Nitric Oxide|DEVICE: respiratory support
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PeptoBismol® Use to Reduce Gastrointestinal Events in Healthy Volunteers Receiving DMF [Tecfidera®] Twice Daily
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: bismuth subsalicylate (Pepto-Bismol®)|DRUG: matching placebo (bismuth subsalicylate)|DRUG: dimethyl fumarate (DMF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study to Observe the Effect of Concomitant Use of Corticosteroid Treatment in Rheumatoid Arthritis (RA) Participants Who Are Treated With a Tumor Necrosis Factor (TNF) Inhibitor or Tocilizumab (TCZ) as Their Second Biological Treatment.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: TNF inhibitor/TCZ
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prospective Randomized Study Comparing Endothelial Cell Loss Using the Tan EndoGlide With Forceps for Insertion of the Donor Graft in DSAEK
Status: UNKNOWN
Conditions: Endothelial Cell Loss With Different Insertion Devices
Interventions: DEVICE: Use of the Tan Endoglide to insert the donor graft|DEVICE: Forceps for delivery of the donor graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Hemay022 in Combination With Endocrine Therapy In Subjects With ER Positive and HER2 Positive Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Hemay022+exemestane|DRUG: Hemay022+letrozole|DRUG: Hemay022+ fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation in Monotherapy
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Lixisenatide (AVE0010)|DRUG: Placebo|DEVICE: Pen auto-injector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Silicone Versus Polyvinylchloride (PVC) Drains Following VATS Lobectomy
Status: COMPLETED
Conditions: Postoperative Pain|Postoperative Complications
Interventions: DEVICE: SIL drain|DEVICE: PVC drain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of XP19986 in Subjects With Symptomatic GERD
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DRUG: XP19986 SR3, 20 mg QD|DRUG: XP19986 SR3, 40 mg QD|DRUG: XP19986 SR3, 60 mg QD|DRUG: XP19986 SR3, 30 mg BID|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of Neutrophil Extracellular Traps in Hypercoagulability and Portal Vein Thrombosis in Liver Cirrhosis Patients
Status: COMPLETED
Conditions: Neutrophil Extracellular Trap Formation|Portal Vein Thrombosis|Liver Cirrhosis
Interventions: DIAGNOSTIC_TEST: test NETs markers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Plasmakinetic Enucleation of the Prostate to Treat Benign Prostatic Hypertrophy Patients With Large Prostate
Status: COMPLETED
Conditions: BPH With Large Prostate
Interventions: PROCEDURE: PkEP|PROCEDURE: B-TURP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Daclatasvir and Sofosbuvir for Genotype 3 Chronic HCV
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Daclatasvir|DRUG: Sofosbuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Response Characterization of VER-01 in the Treatment of Patients With Chronic Non-specific Low Back Pain
Status: RECRUITING
Conditions: Chronic Non-specific Low Back Pain
Interventions: DRUG: VER-01|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenomic Informed Statin Prescribing
Status: NOT_YET_RECRUITING
Conditions: Hypercholesterolemia
Interventions: GENETIC: Pharmacogenetic and polygenic risk testing|OTHER: Active control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Urine Drug Levels Related to Source of Water for Irrigation for Vegetable Crops Among Healthy Israeli Volunteers
Status: COMPLETED
Conditions: Healthy Individuals
Interventions: OTHER: vegetables from fresh or recycled water|OTHER: receives vegetables from fresh water or recycled waste water farms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of Recombinant Humanized Anti-PD-1 mAb for Patients With Locally Advanced or Metastatic Melanoma
Status: UNKNOWN
Conditions: Advanced Melanoma|Metastatic Melanoma
Interventions: BIOLOGICAL: humanized anti-PD-1 monoclonal antibody toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot to Examine Risk and Feasibility of Remote Management of BP From Childhood Into Early Adulthood
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Hypertension|Blood Pressure
Interventions: OTHER: strict blood pressure control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Legumes vs Corn-soy Flour on Environmental Enteric Dysfunction in Rural Malawian Children 1-3 Year Olds
Status: COMPLETED
Conditions: Environmental Enteropathy
Interventions: DIETARY_SUPPLEMENT: cowpeas complementary food|DIETARY_SUPPLEMENT: corn-soy flour|DIETARY_SUPPLEMENT: common bean complementary food
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TAA05 Injection in the Treatment of Adult Patients With FLT3-positive Relapsed/Refractory Acute Myeloid Leukemia
Status: RECRUITING
Conditions: FLT3-positive Relapsed/Refractory Acute Myeloid Leukemia
Interventions: BIOLOGICAL: T cell injection targeting FLT3 chimeric antigen receptor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Rebamipide Effective on the Healing of Iatrogenic Gastric Ulcer After Endoscopic Mucosal Resection?
Status: COMPLETED
Conditions: Stomach Ulcer
Interventions: DRUG: Rebamipide|DRUG: pantoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of a Family Counseling Intervention ("Tuko Pamoja") in Kenya: a Single Case Series Design
Status: COMPLETED
Conditions: Mental Health|Family Relations|Family Conflict|Child Mental Disorder|Adolescent - Emotional Problem|Adolescent Problem Behavior|Child Behavior|Child Abuse|Marital Conflict|Domestic Violence|Parent-Child Relations|Parenting
Interventions: BEHAVIORAL: Tuko Pamoja, "We are Together" in Kiswahili
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Importance of Prostaglandin and Nitric Oxide Synthesis in Apical Periodontitis
Status: COMPLETED
Conditions: Periapical Periodontitis
Interventions: DIAGNOSTIC_TEST: Apical periodontitis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Dopaminergic Modulation of Choroidal Blood Flow Changes During Dark/Light Transitions
Status: COMPLETED
Conditions: Regional Blood Flow|Ocular Physiology
Interventions: DRUG: Quetiapine (drug)|DRUG: Sulpiride (drug)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Androgel on Type 2 Diabetic Males With Hypogonadism
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: androgel|DRUG: androgel 10g|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: HSCT For Patients With High Risk Hemoglobinopathies Using Reduced Intensity
Status: COMPLETED
Conditions: Sickle Cell Disease|Beta Thalassemia-Major
Interventions: DRUG: alemtuzumab (Campath IH)|DRUG: Fludarabine|DRUG: Melphalan|DRUG: Cyclosporine|DRUG: Mycophenolate mofetil|DRUG: Tacrolimus|BIOLOGICAL: Hematopoietic Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Permanently Maintained Healthcare Multidisciplinary Facility (PASS-MULTI) on Unscheduled Readmissions at 12 Months for Persons in Precarious Situations.
Status: UNKNOWN
Conditions: Vulnerable Patients
Interventions: OTHER: pharmaceutical interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of GDC-0810 Versus Fulvestrant in Postmenopausal Women With Advanced or Metastatic Breast Cancer Resistant to Aromatase Inhibitor (AI) Therapy
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Fulvestrant|DRUG: GDC-0810
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Naloxone Auto-injector as a Universal Precaution for Patients With Opioid Use Disorder
Status: COMPLETED
Conditions: Opiate Antagonist Overdose|Opioid-Related Disorders
Interventions: BEHAVIORAL: Naloxone Auto-Injector
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Molecular Fluorescence Endoscopy of (Pre)Malignant Esophageal Lesions
Status: COMPLETED
Conditions: Barrett Esophagus|Esophageal Cancer|Dysplasia in Barrett Esophagus
Interventions: DRUG: IV-administation of EMI-137|DEVICE: Molecular Fluorescence Endoscopy platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Tolerability and Pharmacokinetics(PK)/Pharmacodynamics(PD) Study of GW003 in Healthy Subjects
Status: COMPLETED
Conditions: Chemotherapy-induced Neutropenia
Interventions: BIOLOGICAL: GW003
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: US-Guided ESPB Versus TPVB on Acute and Chronic Pain After VATS
Status: COMPLETED
Conditions: Postoperative Pain|Video-Assisted Thoracoscopic Surgery|Thoracic Paravertebral Block|Erector Spinae Plane Block|Acute Pain|Chronic Pain
Interventions: PROCEDURE: Thoracic paravertebral block vs Erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NOL-Guided Superficial Parasternal Intercostal Plane Block Versus Erector Spinae Plane Block
Status: COMPLETED
Conditions: Analgesia
Interventions: PROCEDURE: Superficial Parasternal Block (SIPB)|PROCEDURE: Erector Spinae Plane Block (ESPB)|DRUG: General anesthetic|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Preemptive Low Dose Norepinephrine Infusion on Intraoperative Hemodynamic Stability and Postoperative Outcomes in Patients Undergoing Brain Tumor Resection With a Craniotomy
Status: NOT_YET_RECRUITING
Conditions: Brain Tumor
Interventions: DRUG: norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Comparative Study of Patient Satisfaction Between Continued Administration of Previous Antipsychotics Versus Switched Administration to Paliperidone ER in Non-satisfied Patients With Previous Antipsychotic Drug
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: Paliperdidone ER|DRUG: Aripiprazole, olanzapine and risperidone (Antipsychotics)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Revisiting A Mobile Intervention to Reduce Pain and Improve Health
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain|Obesity|Sedentary Behavior
Interventions: BEHAVIORAL: MORPH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Role of Anti-IgE in Severe Childhood Eczema
Status: COMPLETED
Conditions: Atopic Eczema|Atopic Dermatitis|Child
Interventions: DRUG: Xolair|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, Tolerability of Pramipexol ER Versus Pramipexol IR Versus Placebo in Early PD Patients
Status: COMPLETED
Conditions: Early Parkinson Disease (Early PD)
Interventions: DRUG: Pramipexol Extended Release|DRUG: Pramipexol Immediate Release|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Qudexy XR for the Prevention of Migraine in Children 6 to 11 Years Old
Status: RECRUITING
Conditions: Migraine Disorders
Interventions: DRUG: Qudexy XR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Reach and Effectiveness of Technology-enhanced Diabetes Prevention Programs
Status: COMPLETED
Conditions: Diabetes Prevention
Interventions: BEHAVIORAL: Choice-Class with IVR Calls|BEHAVIORAL: Random-Class with IVR calls|BEHAVIORAL: Random-Class only|BEHAVIORAL: Choice-DVD with IVR calls|BEHAVIORAL: Random-DVD with IVR calls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of the Transcranial Direct Current Stimulation on the Dopaminergic Transmission in Healthy Subjects
Status: COMPLETED
Conditions: Transcranial Direct Current Stimulation|Dopamine
Interventions: DEVICE: Procedure: active tDCS|DEVICE: Procedure: sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Capacitive Diathermy in the Lumbopelvic Pain
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: DEVICE: Capacitive diathermy (T-CaRe®)|OTHER: Instrumental manual therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BIBR 1048 in the Prevention of Venous Thromboembolism in Patients Undergoing Primary Elective Total Hip Replacement Surgery
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DRUG: BIBR 1048
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise and Nutrition to Improve Pancreatic Cancer Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer
Interventions: BEHAVIORAL: Nutritional Counseling|BEHAVIORAL: Standard Exercise|BEHAVIORAL: Enhanced Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial of High Dose Topotecan With Carboplatin in Patients With Relapsed Ovarian Carcinoma
Status: TERMINATED
Conditions: Ovarian Cancer|Relapses
Interventions: DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy and Safety of Initial Administration of 17 mg Vortioxetine Intravenously With 10 mg/Day Vortioxetine Orally in Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Vortioxetine (IV)|OTHER: Placebo (IV)|DRUG: Vortioxetine (tablet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lymph Node Dissection in High-risk UTUC(Upper Tract Urothelial Carcinoma)
Status: UNKNOWN
Conditions: Recurrence|Metastasis|Upper Tract Urothelial Carcinoma|Lymph Node Dissection
Interventions: PROCEDURE: Lymph node dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial OF Carboplatin, ABI-007 (Abraxane) And Sorafenib (BAY 43-9006) in Metastatic Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: DRUG: Sorafenib (BAY 43-9006)|DRUG: ABI-007(Abraxane)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Patients With Advanced Solid Tumors With Oral Agent ORIN1001 and in Combination With Standard of Care.
Status: ACTIVE_NOT_RECRUITING
Conditions: Effect of Drug
Interventions: DRUG: ORIN1001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Observational Follow-up Study for Subjects Receiving Salvage Therapy After Previous Treatment in a Visilizumab Study for Intravenous Steroid-Refractory Ulcerative Colitis
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: DRUG: Visilizumab (Nuvion®; HuM291)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pinnacle Metal-on-Metal 522 Post-Market Surveillance Study
Status: COMPLETED
Conditions: Pinnacle Metal-on-Metal|Revised Pinnacle Metal-on-Metal|Adverse Local Tissue Reaction|Metal Ions|Total Hip Arthroplasty
Interventions: DEVICE: Pinnacle Metal-on Metal
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intravascular Volumes in Hypoxia During Antarctic Confinement
Status: UNKNOWN
Conditions: Hypoxia|Confinement
Interventions: OTHER: carbon-monoxide rebreathing|OTHER: venous blood sampling|OTHER: physical activity monitoring|OTHER: apnea-hypopnea index and nocturnal oxygenation|OTHER: 24-hour blood pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Single Center Study to Characterize the Absorption, Distribution, Metabolism and Excretion (ADME) of ASA404 After a Single Infusion in Patients With Solid Tumors
Status: TERMINATED
Conditions: Advanced Solid Tumors
Interventions: DRUG: ASA404
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fusion or Cognitive Ultrasound-guided Biopsy to Detect Prostate Cancer
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer|Diagnosis
Interventions: PROCEDURE: Software fusion prostate biopsy|PROCEDURE: Cognitive fusion prostate biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: PARTNER 3 Trial - Mitral Valve in Valve
Status: ACTIVE_NOT_RECRUITING
Conditions: Mitral Valve Insufficiency|Mitral Valve Disease|Mitral Valve Regurgitation|Heart Failure
Interventions: DEVICE: Edwards SAPIEN 3 transcatheter valve, Model 9600TFX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Doxil/Caelyx BE Study
Status: COMPLETED
Conditions: Ovarian Cancer|AIDS-related Kaposi Sarcoma|Multiple Myeloma|Metastatic Breast Cancer
Interventions: DRUG: DOXIL/CAELYX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intraoperative Crystalloid Volume on Postoperative Vomiting
Status: COMPLETED
Conditions: Postoperative Vomiting
Interventions: OTHER: Group 1|OTHER: Group 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: RES® Prepared With RECELL® Compared to Standard of Care Dressings of Partial-thickness Burns in Ages 1-16 Years
Status: TERMINATED
Conditions: Burns
Interventions: DEVICE: RES (Regenerative Epidermal Suspension) prepared using the RECELL® Autologous Cell Harvesting Device|COMBINATION_PRODUCT: Mepilex® Ag Wound Dressing|PROCEDURE: Conventional autografting (only when indicated)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Tele Rehabilitation- Based Task-Specific Training for Cognitive Function Improvement
Status: ACTIVE_NOT_RECRUITING
Conditions: Sclerosis, Multiple
Interventions: DIAGNOSTIC_TEST: Control Group|COMBINATION_PRODUCT: Experimental Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Positron Emission Tomography Imaging With [F-18] FLT Compared to [F-18] FDG in Cancer Patients for Treatment Evaluation
Status: WITHDRAWN
Conditions: Head and Neck Cancer
Interventions: DRUG: [F-18] FLT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of the Preservation of the Gastric Antrum in the Technique of Sleeve Gastrectomy for the Treatment of the Morbid Obesity
Status: COMPLETED
Conditions: Obesity, Morbid
Interventions: PROCEDURE: bariatric surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Biomechanical and Viscoelastic Properties of Plantar Fascia in Pregnant Women
Status: UNKNOWN
Conditions: Pregnant Women
Interventions: OTHER: Evaluation of biomechanics and viscoelastic properties of plantar fascia|OTHER: Evaluation of Foot Morphological Characteristics|OTHER: Evaluation of navıcular mobility|OTHER: Evaluation of Foot Posture
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Singapura Program of All Inclusive Care for the Elderly (SingaPACE) Demonstration Project
Status: COMPLETED
Conditions: Frail Elders
Interventions: BEHAVIORAL: SingaPACE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Home-Based Cardiac Rehabilitation Using a Novel Mobile Health Exercise Regimen Following Transcatheter Heart Valve Interventions
Status: RECRUITING
Conditions: Valvular Heart Disease
Interventions: OTHER: HBCR hands-off|OTHER: HBCR interactive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Interleukin-1 Inhibition on Vascular and Left Ventricular Function in Rheumatoid Arthritis Patients With Coronary Artery Disease
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Coronary Artery Disease|Inflammation
Interventions: DRUG: anakinra|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Simulation Training in Undergraduate Nursing Education as a Means to Improve Awareness of Team Member Roles
Status: COMPLETED
Conditions: Communication
Interventions: BEHAVIORAL: Education on SBAR worksheet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Smart SCALEs With Bioimpedance Analysis for Treatment Guidance in Decompensated Heart Failure
Status: COMPLETED
Conditions: Heart Failure; With Decompensation
Interventions: DEVICE: Seca medical Body Composition Analyser 515
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluating the Addition of Hemodiafiltration to EVLP - Impact on the Regeneration of Marginal Donor Lungs
Status: RECRUITING
Conditions: Lung Diseases
Interventions: DEVICE: hemodiafiltration (HDF)|DEVICE: Ex vivo lung perfusion (EVLP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrated Treatment for Smoking Cessation & Anxiety in People With HIV
Status: COMPLETED
Conditions: Nicotine Dependence|Symptoms of Anxiety|HIV
Interventions: BEHAVIORAL: Integrated cognitive-behavioral therapy for smoking cessation and anxiety|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Radiation Therapy and Cemiplimab for People With Skin Cancer
Status: RECRUITING
Conditions: Cutaneous Squamous Cell Carcinoma|Skin Cancer|Squamous Cell Carcinoma|Locally Advanced Squamous Cell Carcinoma|Locally Advanced Squamous Cell Carcinoma of the Skin|Locally Advanced Cutaneous Squamous Cell Carcinoma|Locally Advanced Skin Squamous Cell Carcinoma
Interventions: DRUG: Cemiplimab|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antineoplaston Therapy in Treating Patients With High-Grade Stage II - Stage IV Non-Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Non-hodgkins Lymphoma
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Statin Treatment in Patients With Asthma
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-dose Interleukin-2 and Pembrolizumab in Melanoma and Renal Cell Cancer
Status: WITHDRAWN
Conditions: Carcinoma, Renal Cell|Melanoma
Interventions: DRUG: Pembrolizumab|DRUG: Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intranasal Ketorolac Tromethamine (Sprix) for Acute Pain of Interstitial Cystitis Flare of Pain
Status: COMPLETED
Conditions: Interstitial Cystitis
Interventions: DRUG: Ketorolac Tromethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: White Fish for Cardiovascular Risk Factors in Patients With Metabolic Syndrome: the WISH-CARE Study
Status: COMPLETED
Conditions: Cardiovascular Risk Factors|Metabolic Syndrome
Interventions: OTHER: Dietary intervention with 7 servings oh white fish per week (each serve consisted of 100g of frozen Namibia hake, Pescanova S.A., Pontevedra, Spain)|OTHER: Previous alimentary habits, avoiding any significant nutritional imbalance, as well as any fish or seafood
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lactobacillus Rhamnosus GG in Reducing Incidence of Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant
Status: COMPLETED
Conditions: Graft Versus Host Disease
Interventions: DIETARY_SUPPLEMENT: Lactobacillus rhamnosus GG|OTHER: laboratory biomarker analysis was not performed because of no differences in the clinical outcomes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Healthy Volunteer Study to Assess the Relative Bioavailability of 2 Forms of SB773812 Tablets.
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: SB- 773812 60 mg|DRUG: SB- 773812 120 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: |Primary Purpose: TREATMENT
Clinical trial: The Purpose of This Registry Study is to Learn More About Metabolic Health: Approximately 15,000 Participants Who Are Overweight or Have Obesity With or Without Metabolic Diseases Are Expected to Participate in This Registry Study.
Status: WITHDRAWN
Conditions: Metabolic Health
Interventions: DRUG: Tirzepatide|DRUG: Semaglutide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness and Safety Study of Peripheral Balloon Dilatation Catheter in Percutaneous Transluminal Angioplasty(PTA) Procedure
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: percutaneous transluminal angioplasty balloon catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Dexterous Terminal Device
Status: WITHDRAWN
Conditions: Amputation|Amputation, Traumatic|Amputation; Traumatic, Hand|Limb; Absence, Congenital, Upper|Prosthesis User|Upper Limb Amputation Below Elbow (Injury)|Upper Limb Amputation at the Hand
Interventions: DEVICE: Pointdexter|DEVICE: Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: The Effect of Structured Transition Care Model Applied to Adolescents With Congenital Heart Disease
Status: NOT_YET_RECRUITING
Conditions: Congenital Heart Disease in Adolescence
Interventions: BEHAVIORAL: Transitional care training with brochures, posters and slide training materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Expanded Access Treatment With [Lu-177]-PNT2002 for Adult Patients With Prostate-Specific Membrane Antigen (PSMA)-Positive Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Status: AVAILABLE
Conditions: Castration-Resistant Prostatic Cancer
Interventions: DRUG: [Lu-177]-PNT2002
Study Type: EXPANDED_ACCESS
Clinical trial: The Role of Oxytocin-receptor Signalling in Physiological Regulation of Eating Behaviour in Individuals With Obesity
Status: RECRUITING
Conditions: Adiposity
Interventions: DRUG: Oxytocin|OTHER: Placebo (saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Huang-long Zhi-xiao Granule Improves the Control Rate of Chronic Persistent of Asthma
Status: NOT_YET_RECRUITING
Conditions: Asthma Chronic
Interventions: DRUG: Huang-long Zhi-xiao Granule|DRUG: Huang-long Zhi-xiao Granule placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Menthol on ENDS Users' Addiction and Exposure
Status: RECRUITING
Conditions: Electronic Cigarette Use
Interventions: OTHER: Menthol-flavored e-cigarette|OTHER: Tobacco-flavored e-cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Multimodality Intervention for Function and Metabolism in SCI
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: DRUG: Testosterone Undecanoate|BEHAVIORAL: hybrid exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Timing of Misoprostol Administration Prior to Office Hysteroscopy
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Long interval misoprostol|DRUG: Short interval misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Obatoclax and Bortezomib in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma
Interventions: DRUG: obatoclax mesylate|DRUG: bortezomib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Buprenorphine Transdermal Patches (BTDS) in Subjects With Osteoarthritis Pain. Includes a 52-week Extension Phase.
Status: TERMINATED
Conditions: Osteoarthritis
Interventions: DRUG: Buprenorphine transdermal patch|DRUG: Buprenorphine transdermal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prognostic Imaging Biomarkers for Diabetic Kidney Disease
Status: RECRUITING
Conditions: Diabetic Kidney Disease
Interventions: DIAGNOSTIC_TEST: MRI (magnetic resonance imaging)|DIAGNOSTIC_TEST: US (ultrasound)|PROCEDURE: Renal Biopsy|DIAGNOSTIC_TEST: Positron Emission Tomography (PET)|DIAGNOSTIC_TEST: Microvascular Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Delgocitinib Cream for the Treatment of Moderate to Severe Atopic Dermatitis During 8 Weeks in Adults, Adolescents, and Children
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: delgocitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Reverse Flow Based Flap VS Palatal Pedicled Flap for Closure of Recurrent Small & Medium Sized Oronasal Fistula.
Status: COMPLETED
Conditions: Patient Satisfaction
Interventions: PROCEDURE: Curing small and medium sized oronasal fistula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Crinone 8% Intravaginal Gel and IM Progesterone Supplementation for In Vitro Fertilization (IVF)
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Crinone 8% Vaginal Gel|DRUG: Intramuscular Progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Drug Drug Interaction Between Milvexian and Atorvastatin in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Milvexian|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Virtual Therapeutic Garden for Depressive Symptoms
Status: COMPLETED
Conditions: Depressive Symptoms|Depression|Anxiety
Interventions: BEHAVIORAL: Group general fitness training|BEHAVIORAL: Group relaxation and psychoeduaction|DEVICE: VRTierOne
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preclinical Studies of Omalizumab in Chronic Rhinosinusitis With Nasal Polyposis
Status: COMPLETED
Conditions: Chronic Rhinosinusitis With Nasal Polyps|Nasal Polyps
Interventions: BIOLOGICAL: Omalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Observation on the Efficacy of Dual Therapy Based on Vonoprazan in Eradicating Helicobacter Pylori
Status: NOT_YET_RECRUITING
Conditions: The Eradication Rate of Helicobacter Pylori
Interventions: DRUG: Vonopazan +Amoxicillin|DRUG: Rabeprazole +colloidal pectin bismuth +Amoxicillin +Clarithromycin|DRUG: Vonopazan +Minocycline|DRUG: Rabeprazole +colloidal pectin bismuth +Metronidazole +Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of 4 New Simplified Antiretroviral Treatments in Naive HIV-1 Infected Patients in Africa (ANRS 12115 DAYANA)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Tenofovir/Emtricitabine (Truvada) and Nevirapine|DRUG: Tenofovir/Emtricitabine/Efavirenz (Atripla)|DRUG: Tenofovir (Viread) and Lopinavir/Ritonavir (Aluvia)|DRUG: Tenofovir/Emtricitabine (Truvada) and Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NP001, Alzheimer's Disease, and Blood Markers of Inflammation
Status: TERMINATED
Conditions: Alzheimer Disease
Interventions: DRUG: NP001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Anti-TSLP in Patients With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: MEDI9929|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-Intensity Exercise and Endothelial Function in Type 1 Diabetes(HIIT-T1D)
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus|Endothelial Dysfunction
Interventions: BEHAVIORAL: High Intensity Interval Training|BEHAVIORAL: Moderate Continuous Exercise Training|OTHER: Non-exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hydroxyurea in the Emergency Room to Lessen Pain in Sickle Cell Crisis
Status: UNKNOWN
Conditions: Anemia, Sickle Cell|Anemia; Sickle-Cell, With Crisis
Interventions: DRUG: Hydroxyurea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Heart Disease (CHD)
Interventions: DRUG: Evolocumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SRS Sequential Sindilimab in Brain Metastasis of NSLSC
Status: UNKNOWN
Conditions: NSCLC Stage IV|Brain Metastases|SRS|Sintilimab
Interventions: COMBINATION_PRODUCT: SRS sequential sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Downstaging of Extraperitoneal T3 Rectal Cancer: XELOXRT Versus XELACRT. A Multicenter, Phase III Study
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: DRUG: XELAC RT|DRUG: XELOX RT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT on Intralesional Rituximab Injection Versus ISRT in Ocular Adnexal MALT Lymphoma
Status: RECRUITING
Conditions: Primary Ocular Adnexal MALT Lymphoma
Interventions: DRUG: Rituximab|RADIATION: Involved Site Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT