pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Meta-Analyses of the Effect of Vegetable Protein for Animal Protein on Cardiometabolic Risk
Status: UNKNOWN
Conditions: Diabetes|Prediabetes|Metabolic Syndrome|Dysglycemia|Overweight|Obesity|Dyslipidemia|Hypertension|Gout|Non-alcoholic Fatty Liver Disease (NAFLD)|Kidney Disease|Kidney Injury|Cardiovascular Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Furosemide on ESWL Outcomes for Renal and Ureteral Calculi
Status: UNKNOWN
Conditions: Urolithiasis|Nephrolithiasis|Urinary Calculi|Ureterolithiasis
Interventions: DRUG: Furosemide 40 mg|OTHER: Conventional Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of CoDuSe Balance Training and Step Square Exercises on Risk of Fall in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: OTHER: CoDuSe balance training and step square exercises|OTHER: conventional balance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heterogeneity Informed Nutrition Therapy for Gestational Diabetes Mellitus
Status: UNKNOWN
Conditions: Gestational Diabetes
Interventions: OTHER: Meal A|OTHER: Meal B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Organ Donation Interventions Among High Students
Status: TERMINATED
Conditions: Tissue and Organ Procurement|Adolescent Behavior|Communication
Interventions: BEHAVIORAL: Video Interventions|BEHAVIORAL: Donation Discussion Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Immunogenicity of an Intranasal Vaccine for Respiratory Syncytial Virus in Seronegative Children 6-36 Months
Status: UNKNOWN
Conditions: Respiratory Syncytial Virus (RSV)
Interventions: BIOLOGICAL: Investigational RSV vaccine MV-012-968 (Dosage 1)|BIOLOGICAL: Investigational RSV vaccine MV-012-968 (Dosage 2)|BIOLOGICAL: Investigational RSV vaccine MV-012-968 (Dosage 3; single-dose)|BIOLOGICAL: Investigational RSV vaccine MV-012-968 (Dosage 3; two-dose)|OTHER: Placebo (single-dose)|OTHER: Placebo (two-dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of Cinacalcet for the Treatment of Hypercalcemia in Patients With Primary Hyperparathyroidism Unable to Undergo Parathyroidectomy
Status: COMPLETED
Conditions: Hyperparathyroidism, Primary|Hypercalcemia
Interventions: DRUG: Cinacalcet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanical Insufflation-Exsufflation Compared With CPAP in Patients Admitted to an Intermediate Care Unit With Pneumonia
Status: COMPLETED
Conditions: Pneumonia
Interventions: DEVICE: Mechanical insufflation-exsufflation (MIE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of 18 FDG PET/CT on the Management of Patients With Staphylococcus Aureus Bloodstream Infection
Status: UNKNOWN
Conditions: Staphylococcus Aureus
Interventions: PROCEDURE: PET/CT Positron emission tomography (PET) using small radiotracers, a special camera and a computer to evaluate organ and tissue functions|OTHER: Patients' routine care with performance of explorations based on anamnesis and clinical symptoms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Relative Bioavailability of Empagliflozin (BI 10773) and Ramipril Administered Together Compared to Empagliflozin (BI 10773) and Ramipril Alone in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 10773|DRUG: Ramipril|DRUG: BI 10773|DRUG: Ramipril|DRUG: Ramipril|DRUG: Ramipril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Divestment for Artery-involved Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer|Locally Advanced Pancreatic Cancer|Neoadjuvant Therapy|Borderline Resectable Pancreatic Cancer
Interventions: PROCEDURE: Artery Divestment Technique|DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability and Pharmacokinetics of Repeated Dosing Regimens of AL-794 in Healthy Volunteers
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: AL-794|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Emergent Stenting In Acute Vertebrobasilar Occlusions
Status: COMPLETED
Conditions: Acute Stroke|Ischemic Stroke, Acute|Vertebro Basilar Ischemia
Interventions: PROCEDURE: Emergent Stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Safety and Efficacy of IM19 for Relapsed or Refractory NHL Patients
Status: UNKNOWN
Conditions: Non Hodgkin Lymphoma
Interventions: BIOLOGICAL: IM19|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monthly Versus Daily Buprenorphine Formulations for Treatment of Opiate Use Disorder
Status: NOT_YET_RECRUITING
Conditions: Moderate to Severe Opioid Use Disorder
Interventions: DRUG: Extended Release Subcutaneous Buprenorphine|DRUG: Immediate Release Sublingual Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MRI and CT Simulation in the Evaluation of Tumor Response and Target Volume Definition for Esophageal or Esophagogastric Cancer Patients Undergoing Chemoradiotherapy
Status: RECRUITING
Conditions: Esophagus Cancer|Esophagogastric Junction Cancer
Interventions: DEVICE: MRI and CT|RADIATION: Ratiotherapy|DRUG: Paclitaxel, platinum-based drug
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Asses Efficacy, Safety and Tolerability of Monthly Long-acting IM Injection of GA Depot in Subjects With RMS
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: GA Depot|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Two Types of Cognitive Training in Veterans With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Brain Fitness Program (BFP)|BEHAVIORAL: Cognitive Package (Cogpack)|BEHAVIORAL: Commercial Computer Games (Sporcle)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-stroke Haptic Feedback Use Deficit: A Comparative and Reliability Study
Status: NOT_YET_RECRUITING
Conditions: Stroke|Upper Extremity Paresis|Manual Dexterity|Sensory Integration Dysfunction|Vibration; Disorder
Interventions: DEVICE: Dextrain Manipulandum and haptic feedback device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Hypertrophic Scar Prevention by Novel Topical Gel Application
Status: TERMINATED
Conditions: Hypertrophic Scar
Interventions: DRUG: Pentamidine Isethionate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Trichuris Suis Ova in Autism Spectrum Disorders
Status: COMPLETED
Conditions: Autism
Interventions: DRUG: Trichuris Suis Ova
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effects of Three Oral Care Regimens
Status: COMPLETED
Conditions: Dental Plaque|Gingivitis
Interventions: OTHER: Toothbrushing|OTHER: Fluoridated Dentifrice (.15% sodium monofluorophosphate)|OTHER: Fluoridated Dentifrice Whitening System (.454% stannous fluoride with 2% hydrogen peroxide)|OTHER: Whitening (4.5% hydrogen peroxide)|OTHER: Other Fluoridated Dentifrice (.454% stannous fluoride)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I Biomarker Study (BMS-936558)
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: BMS-936558 (Anti-PD-1)|DRUG: BMS-936558 (Anti-PD-1)|DRUG: BMS-936558 (Anti-PD-1)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Desmopressin for Reversal of Antiplatelet Drugs in Stroke Due to Haemorrhage
Status: COMPLETED
Conditions: Stroke, Acute
Interventions: DRUG: Desmopressin Injection|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Addition of Polychemotherapy to Adjuvant Radiotherapy in the Treatment of Non-Metastatic Uterine Sarcomas
Status: UNKNOWN
Conditions: Uterine Sarcoma
Interventions: DRUG: doxorubicin, ifosfamide, cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of a Modified Dentoalveolar Distractor to Retract Maxillary Canines
Status: COMPLETED
Conditions: Orthodontic Patients Requiring Canine Retraction
Interventions: DEVICE: modified dentoalveolar distractor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Preemptive Etoricoxib and Dexamethasone on Wound Healing and Clinical Parameters After Third Molar Surgery
Status: COMPLETED
Conditions: Surgical Wound|Post Operative Pain
Interventions: DRUG: Etoricoxib 90 Mg Oral Tablet|DRUG: Dexamethasone 4mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Effect of Itraconazole on the Pharmacokinetics (PK) of Nemiralisib
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Nemiralisib|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Calcium Chloride Injection in Alleviating Atrial Fibrillation Post CABG
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DRUG: Calcium Chloride|DRUG: Sodium Chloride 0.9% Inj
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Shaping the Indications for Periodontal Adjunctive Antibiotics in Dental Practice
Status: RECRUITING
Conditions: Periodontitis|Periodontal Diseases|Periodontal Pocket
Interventions: DRUG: Amoxicillin|DRUG: Metronidazole|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Compared to Placebo in Subjects With Acute Blunt Trauma Injuries
Status: COMPLETED
Conditions: Acute Blunt Soft Tissue Injuries/Contusions
Interventions: DRUG: placebo|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Cleaning Regimes on Biofilm Formation of Acrylic Based Removable Orthodontic Appliance
Status: RECRUITING
Conditions: Oral Disease
Interventions: OTHER: cleaning removable acrylic appliance with denture brush and chlorhexidine toothpaste|OTHER: cleaning removable acrylic appliance with cleansing tablet|OTHER: combination of mechanical and chemical cleaning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of the Anti-inflammatory Flavonoid Luteolin on Behavior in Children With Autism Spectrum Disorders
Status: COMPLETED
Conditions: Autism Spectrum Disorders
Interventions: DIETARY_SUPPLEMENT: Luteolin, Quercetin and Rutin combined in a capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-selenium Lentils Versus Arsenic Toxicity
Status: COMPLETED
Conditions: Arsenic Poisoning
Interventions: DIETARY_SUPPLEMENT: high-selenium lentils|DIETARY_SUPPLEMENT: Low-Se lentils
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study in Participants With Homozygous Familial Hypercholesterolemia (HoFH)
Status: COMPLETED
Conditions: Homozygous Familial Hypercholesterolemia
Interventions: DRUG: Alirocumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GP vs PF as Induction Chemotherapy Combined With CCRT for Locoregionally Advanced Nasopharyngeal Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Nasopharyngeal Carcinoma|Nasopharyngeal Neoplasms|Nasopharyngeal Diseases|Head and Neck Neoplasm
Interventions: DRUG: gemcitabine and cisplatin|DRUG: cisplatin and fluorouracil|RADIATION: IMRT|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Meleis's Transition Theory on Postpartum Difficulties and Quality of Life in Primipara Mothers
Status: COMPLETED
Conditions: Postpartum Care|First Birth|Cesarean Section
Interventions: OTHER: Training and Consultancy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Veteran Social Support for Enhancing Use of Smoking Cessation Treatment
Status: RECRUITING
Conditions: Smoking Cessation|Veterans Health
Interventions: BEHAVIORAL: Support Person Coaching Call|BEHAVIORAL: SP written materials|BEHAVIORAL: Written Smoking Cessation Materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Dose-Ranging Phase II Study of AUR101 in Psoriasis (INDUS-3)
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: AUR101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cotrimoxazole Prophylaxis Cessation Study Among Stabilized HIV-Infected Adult Patients on HAART in Entebbe, Uganda
Status: UNKNOWN
Conditions: HIV Infections
Interventions: DRUG: cotrimoxazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics of Benzo[a]Pyrene: Impact of Diet
Status: COMPLETED
Conditions: Environmental Exposure
Interventions: DRUG: [14C]-benzo[a]pyrene|DRUG: Brussels sprouts before 50 ng dose|DRUG: DIM supplement before 50 ng dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neoadjuvant Sitravatinib in Combination With Nivolumab in Patients With Clear Cell Renal Cell Carcinoma
Status: COMPLETED
Conditions: Clear Cell Renal Cell Carcinoma
Interventions: DRUG: Sitravatinib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Fructose on Microbiota and Hepatosteatosis
Status: COMPLETED
Conditions: Hepatic Steatosis|Dietary Fructose Exposure
Interventions: DIETARY_SUPPLEMENT: 75g fructose solution|DIETARY_SUPPLEMENT: 150g fructose solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: FES VS Constrained Induced MT Recovery and Spasticity in Upper Limb Hemiparetic Ischemic Patients
Status: RECRUITING
Conditions: Stroke
Interventions: DIAGNOSTIC_TEST: Functional Electrical Stimulation|DIAGNOSTIC_TEST: Constrained Induced Movement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: GW640385 Plus Ritonavir And NRTIs For 48 Weeks In HIV-1 Infected Adults
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus I|HIV Infection
Interventions: DRUG: GW640385|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VEGF Levels in Aqueous, Vitreous and Subretinal Fluid in ROP Stage IV and V
Status: WITHDRAWN
Conditions: Retinopathy of Prematurity
Interventions: PROCEDURE: Vitrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Carbon-13 (13C)-Spirulina Platensis Gastric Emptying Breath Test (GEBT)
Status: COMPLETED
Conditions: Dyspepsia
Interventions: DRUG: [13C]-Spirulina platensis and 99mTc sulfur colloid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical and Economic Impact of an Electronic Medical Record Interfaced Decision Support System Reinforced With Patient Specific Pharmacogenetic Data for Minimizing Severe Drug-Drug Interactions
Status: COMPLETED
Conditions: Healthcare
Interventions: OTHER: DDI+ System and Pharmacogenetic Data
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Acupuncture in Patients With Carpal Tunnel Syndrome ~ A Randomized Controlled Trial
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: OTHER: Acupuncture|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brief Transdiagnostic Treatment for Anxiety Disorders and Post-traumatic Stress Disorder (PTSD) in South Africa
Status: RECRUITING
Conditions: Anxiety Disorders|Post-traumatic Stress Disorder
Interventions: BEHAVIORAL: False Safety Behavioral Elimination Treatment (FSET)|BEHAVIORAL: Enhanced Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stimulating Catheter for Lumbar Plexus Block: Better Postoperative Analgesia?
Status: COMPLETED
Conditions: Hip Replacement Arthroplasty
Interventions: PROCEDURE: Continuous lumbar plexus: stimulating catheter|PROCEDURE: Spinal Anesthesia|PROCEDURE: Local anesthetic infusion|PROCEDURE: Intravenous analgesia|PROCEDURE: Opioids rescue analgesia|DRUG: Mepivacaine 1%|DRUG: Levobupivacaine 0,5%|DRUG: Ropivacaine 0,2%|DRUG: Ketorolac 30mg|DRUG: Buprenorphine 0,2mg|DEVICE: Stimulong, Pajunk, Germany.|PROCEDURE: Continuous lumbar plexus: non-stimulating catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of ATNC-MDD V1(TMS With Cognitive Training) in Mild Alzheimer's Dementia
Status: RECRUITING
Conditions: Alzheimer's Disease|Dementia|Brain Diseases|Central Nervous System Diseases|Nervous System Diseases|Neurodegenerative Diseases|Neurocognitive Disorders|Mental Disorder
Interventions: DEVICE: ATNC MDD-V1 (Real TMS + Real Cog)|DEVICE: ATNC MDD-V1 (Sham TMS + Real Cog)|DEVICE: ATNC BN-V1|DEVICE: ATNC BN-V2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Actamax™Adhesion Barrier in Women Undergoing Laparoscopic Abdominopelvic Surgery/Myomectomy
Status: UNKNOWN
Conditions: Uterine Fibroid
Interventions: DEVICE: Actamax™Adhesion Barrier
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NISCI - Nogo Inhibition in Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury, Acute
Interventions: DRUG: NG-101|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Hypertonic Saturated Saline Mouth Rinse on Covid-19 Virus in Vivo.
Status: WITHDRAWN
Conditions: Covid19
Interventions: DRUG: Hypertonic Saturated Saline Mouth Rinse Active Arm|OTHER: Placebo Plain Water Mouth Rinse Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Pregabalin on Postoperative Pain After Cardiac Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Pregabalin 75mg|DRUG: pregabalin 150 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy, Acceptability and Cost-effectiveness of Long Lasting Insecticide Nets (LLIN) in the Prevention of Kala Azar
Status: COMPLETED
Conditions: Visceral Leishmaniasis|Kala Azar
Interventions: DEVICE: Long Lasting Impregnated Nets (LLIN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Tranexamic Acid in Upper Gastrointestinal Bleeding
Status: UNKNOWN
Conditions: Gastro Intestinal Bleeding
Interventions: DRUG: Tranexamic acid|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Smartphone-based Aftercare for Inpatients With Bulimia Nervosa
Status: RECRUITING
Conditions: Bulimia Nervosa
Interventions: BEHAVIORAL: Recovery Record Aftercare|BEHAVIORAL: Treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Nimotuzumab Plus Concurrent Chemoradiotherapy Sequential Maintenance Treatment for Cervical Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Cervical Cancer
Interventions: BIOLOGICAL: Nimotuzumab|DRUG: Cisplatin|RADIATION: External Beam Radiotherapy (EBRT)|RADIATION: Brachytherapy|DRUG: placebo for Nimotuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Increasing Exercise Capacity of Patients With Heart Failure by Wii Gaming
Status: COMPLETED
Conditions: Heart Failure
Interventions: BEHAVIORAL: Structured access to a Wii game computer (Wii)|BEHAVIORAL: Motivational support only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tele-based Psychological Emotional Support for Informal CARegivers of COVID-19 Patients in Intensive Care
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder|Prolonged Grief Disorder|COVID
Interventions: BEHAVIORAL: Tele-delivered psychological intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatments Against RA and Effect on FDG-PET/CT
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Methotrexate|DRUG: Sulfasalazine|DRUG: Hydroxychloroquine|DRUG: Etanercept|DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Natriuretic Peptide System as Therapy in Human Preclinical Left Ventricle Dysfunction
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: DRUG: Nesiritide|DRUG: Placebo|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Elderly Subjects
Status: COMPLETED
Conditions: Pandemic H5N1 Influenza
Interventions: BIOLOGICAL: Adjuvanted H5N1 pandemic influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: RCT, Blinded, 2-Arm Efficacy Study of IP and Placebo in Patients With Chronic Pain Related to Osteoarthritis of the Knee
Status: UNKNOWN
Conditions: Degenerative Arthritis
Interventions: DRUG: Placebo|DRUG: Ibuprofen modified release tablet 800 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zolpidem Tartrate 10 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Zolpidem 10 mg tablets|DRUG: AMBIEN® 10 mg tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Immunogenicity in Dose-Ranging and Formulation-Finding Meningococcal B (MenB) Vaccine Study in 2-month-old Infants
Status: COMPLETED
Conditions: Meningococcal Meningitis|Meningococcal Infections
Interventions: BIOLOGICAL: Meningococcal B vaccine|BIOLOGICAL: Meningococcal B vaccine|BIOLOGICAL: Meningococcal B vaccine|BIOLOGICAL: Meningococcal B vaccine|BIOLOGICAL: Meningococcal B vaccine|BIOLOGICAL: Meningococcal B vaccine|BIOLOGICAL: Control|BIOLOGICAL: Meningococcal B vaccine with antipyretic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Phase II Study of IMRT With SIB as Adjuvant Treatment for High Risk Resected Well-differentiated Thyroid Cancer.
Status: COMPLETED
Conditions: Thyroid Neoplasms
Interventions: PROCEDURE: IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caudal Combination of Dexamethasone and/or Dexmedetomidine to Bupivacaine in Pediatric Hypospadias Surgery
Status: COMPLETED
Conditions: Caudal Block
Interventions: DRUG: Dexamethasone|DRUG: Dexmedetomidine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Progression Rate of MSA Under EGCG Supplementation as Anti-Aggregation-Approach
Status: COMPLETED
Conditions: Multiple System Atrophy
Interventions: DRUG: EGCG as putative neuroprotective agent|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Interventional Pulmonary Rehabilitation Exercise With Advanced Lung Cancer.
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer|Pulmonary Rehabilitation|Exercise|Lung Adenocarcinoma|Lung Tumor|Lung Neoplasms|Advanced Lung Cancer|Self Efficacy|Quality of Life|Psychological Distress
Interventions: BEHAVIORAL: pulmonary rehabilitation exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigate a Pharmacokinetics Between S-pantoprazole 20mg and Pantoprazole 40mg in Healthy Male Subjects
Status: UNKNOWN
Conditions: Healthy Male Subjects
Interventions: DRUG: AGSPT_L20|DRUG: Pantoloc 40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Pivotal Study of SYN010 HFA Inhaler and Symbicort® 160/4.5 in Healthy Volunteers Without Charcoal Block
Status: COMPLETED
Conditions: Asthma|COPD
Interventions: DRUG: Budesonide|DRUG: Formoterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of All'InCath in Peripheral Vasculature Percutaneous Transluminal Angioplasty.
Status: UNKNOWN
Conditions: Vascular Diseases
Interventions: DEVICE: All'InCath CBC 035M Balloon Dilatation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Improving Cerebral Autoregulation in Acute Intracerebral Haemorrhage
Status: COMPLETED
Conditions: Stroke, Acute|Hemorrhage|Cerebral Brain Hemorrhage|Blood Pressure
Interventions: OTHER: Hypocapnia via Hyperventilation Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Renoir: A Randomised, Double-blind, Controlled Trial to Evaluate the Effects of a New Human Milk Fortifier on Growth and Tolerance in Preterm Infants.
Status: UNKNOWN
Conditions: Subjects in Need of a Human Milk Fortifier (HMF)|Growth|Tolerance|Safety
Interventions: OTHER: Test product|OTHER: Control product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Rheopheresis Blood Filtration Study for the Treatment of Dry Age-Related Macular Degeneration (AMD)
Status: UNKNOWN
Conditions: Macular Degeneration
Interventions: DEVICE: Rheopheresis blood filtration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Iovera° Device for Temporary Relief From Knee Pain
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: iovera°|DEVICE: Sham Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Residence Time Evaluation of Systane Ultra Lubricant Eye Drops vs. Hialid and Saline
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: OTHER: Systane Ultra Lubricant Eye Drops|OTHER: Hialid 0.1 Artificial Tears Eye Drops|OTHER: Unisol 4 Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3, Vehicle-controlled Efficacy and Safety Study of IDP-123 Lotion in the Treatment of Acne Vulgaris (301)
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: IDP-123 Lotion|DRUG: IDP-123 Vehicle Lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neuroplasticity Induced by General Anaesthesia
Status: COMPLETED
Conditions: Healthy Volunteers|General Anaesthesia|Neuroplasticity
Interventions: DRUG: Sevoflurane-propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Minimal Invasive Deformity Correction (MID-C) System for Early Onset Scoliosis
Status: UNKNOWN
Conditions: Scoliosis|Scoliosis Idiopathic|Scoliosis;Congenital
Interventions: DEVICE: MID-C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study is to Evaluate the Effect of Multiple Doses PF-06751979 on the Pharmacokinetics of Midazolam in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: midazolam|DRUG: PF-06751979
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intrawound Administration of Vancomycin in TKA
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Intrawound administration of vancomycin after closure of the arthrotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Function Changes and Diaphragmatic Paralysis Following Ultrasound Guided Supraclavicular Brachial Plexus Blockade: The Effects of Decreased Local Anesthetic Volume
Status: COMPLETED
Conditions: Diaphragmatic Function|Lung Function
Interventions: PROCEDURE: Supraclavicular Block
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Effect of Carbetocin on the QT/QTc Interval in Healthy Subjects
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Carbetocin|DRUG: Placebo|DRUG: Placebo and Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Finding Study To Evaluate Safety, Tolerability, and Efficacy of E2609 in Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (Prodromal Alzheimer's Disease) and Mild to Moderate Dementia Due to Alzheimer's Disease
Status: TERMINATED
Conditions: Alzheimer Disease|Dementia, Alzheimer Type
Interventions: DRUG: E2609|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gene Therapy in Patients With Mucopolysaccharidosis Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Mucopolysaccharidosis Type VI
Interventions: BIOLOGICAL: AAV2/8.TBG.hARSB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous HBV-specific T Cell Receptor Engineered T Cells (TCR-T) in Patients With HBV-related Advanced HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: GENETIC: SCG101|BIOLOGICAL: PD1/PD-L1 checkpoint inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caudal Versus S1 Transforaminal Epidural Steroid Injection for the Treatment of Unilateral S1 Radiculopathy
Status: RECRUITING
Conditions: Lumbosacral Radiculopathy
Interventions: PROCEDURE: Transforaminal epidural steroid injection|PROCEDURE: Caudal epidural steroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Tolerability Study of Assisted and Self-Administered Subcutaneous (SC) Herceptin (Trastuzumab) as Adjuvant Therapy in Early Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Herceptin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lovastatin as a Potential Modulator of Apoptosis in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Lovastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Satiety Following Oral Administration of an Erythritol Sweetened Beverage
Status: COMPLETED
Conditions: Satiety in Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: Erythritol|DIETARY_SUPPLEMENT: Aspartame
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A 6-Month Open-Label Extension Study to the B2061014 Study to Evaluate the Safety, Tolerability and Efficacy of DVS SR in the Treatment of Children and Adolescents With MDD
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: DVS SR
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PV-10 in Combination With Pembrolizumab for Treatment of Metastatic Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: DRUG: PV-10|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy, Safety, and Pharmacokinetics Study of Beloranib in Obese Subjects With Prader-Willi Syndrome
Status: COMPLETED
Conditions: Obesity|Over-weight|Prader-Willi Syndrome
Interventions: DRUG: ZGN-440 sterile diluent|DRUG: 1.2 mg ZGN-440 for injectable suspension|DRUG: 1.8 mg ZGN-440 for injectable suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluating Vitamin D Normalization on Major Adverse Cardiovascular-Related Events Among Myocardial Infarction Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Death|Myocardial Infarction|Cerebral Vascular Accident|Heart Failure Hospitalization
Interventions: BIOLOGICAL: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BrUOG 390: Neoadjuvant Treatment With Talazoparib
Status: TERMINATED
Conditions: BRCA1 Mutation|BRCA2 Mutation|Ovarian Cancer|Fallopian Tube Cancer|High Grade Serous Carcinoma
Interventions: DRUG: Talazoparib Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Tissue Adhesives in Port Site Closure
Status: RECRUITING
Conditions: Dermatitis, Contact
Interventions: DEVICE: 2-Octylcyanoacrylate|DEVICE: N-butyl-2-cyanoacrylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Improvement Through tDCS for Patients With Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis
Interventions: DEVICE: Active transcranial direct current stimulation|DEVICE: Sham transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Effectiveness of Nutritional Practical Counseling for Elderly Patients at Risk of Malnutrition on Nutritional Status at Home
Status: TERMINATED
Conditions: Malnutrition
Interventions: OTHER: dietary counseling|OTHER: nutritional workshop with enrichment during a meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Eszopiclone on Adherence to CPAP and Severity of Insomnia in Patients With COMISA
Status: RECRUITING
Conditions: Obstructive Sleep Apnea|Insomnia
Interventions: DRUG: Eszopiclone 3 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating ASTRA TECH Implant System, OsseoSpeed™ Implants in the Upper Jaw in Women With Osteoporosis
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis|Osteopenia|Jaw, Edentulous, Partially
Interventions: DEVICE: OsseoSpeed™
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Autologous CD8+ and CD4+ Engineered T Cell Receptor T Cells in Subjects With Advanced or Metastatic Solid Tumor
Status: RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma|Non-Small Cell Lung Cancer|Colorectal Cancer|Solid Tumor|KRAS G12V
Interventions: DRUG: AFNT-211
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Hydrochloride and Cisplatin or High-Dose Methotrexate, Vinblastine, Doxorubicin Hydrochloride, and Cisplatin in Treating Patients With Urothelial Cancer
Status: WITHDRAWN
Conditions: Anterior Urethral Cancer|Localized Transitional Cell Cancer of the Renal Pelvis and Ureter|Posterior Urethral Cancer|Recurrent Bladder Cancer|Recurrent Urethral Cancer|Regional Transitional Cell Cancer of the Renal Pelvis and Ureter|Stage III Bladder Cancer|Transitional Cell Carcinoma of the Bladder|Ureter Cancer|Urethral Cancer Associated With Invasive Bladder Cancer
Interventions: DRUG: cisplatin|DRUG: gemcitabine hydrochloride|DRUG: methotrexate|DRUG: vinblastine|DRUG: doxorubicin hydrochloride|BIOLOGICAL: pegfilgrastim|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Face-To-Face and Online-Education Provided To İndividuals With Atrial Fibrillation On Medication Adherence and Satisfaction
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: OTHER: Online education|OTHER: Face-to-face education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Serratus Anterior Plane Block for Modified Radical Mastectomy: Double-point VS Single-point
Status: COMPLETED
Conditions: Mammary Cancer|Serratus Anterior Plane Block|Postoperative Pain
Interventions: PROCEDURE: Double-point SAPB|PROCEDURE: Single-point SAPB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pediatric Ketamine Study for Pain Management
Status: TERMINATED
Conditions: Pain
Interventions: DRUG: Ketamine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erlotinib and Radiation Therapy in Treating Older Patients With Stage I, Stage II, Stage III, or Stage IV Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: erlotinib hydrochloride|OTHER: immunohistochemistry staining method|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: rTMS Over the Supplementary Motor Area for Treatment-resistant Obsessive-compulsive Disorder.
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: rTMS (repetitive transcranial magnetic stimulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: B Cell Maturation Antigen（BMCA）-Targeted CAR-T for Refractory/Relapsed Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: CAR-T treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of Moxonidine on Bone Metabolism, Vascular and Cellular Aging in Hypertensive Postmenopausal Women
Status: COMPLETED
Conditions: Osteopenia|Arterial Hypertension
Interventions: DRUG: Moxonidine|DRUG: Bisoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The 5 Repetitions Sit-to-stand Test, Carried Out Remotely Via Videoconference, in Patients With COPD: Is There a Learning Effect?
Status: COMPLETED
Conditions: Chronic Respiratory Disease
Interventions: OTHER: 5STS remote assessment via videoconference
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Potential for HPV Self-testing to Promote Participation in Cervical Screening
Status: WITHDRAWN
Conditions: Cervix Diseases
Interventions: PROCEDURE: Self-collecting a vaginal sample with a swab for HPV testing|PROCEDURE: Collection of cervical sample for routine cervical screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION