pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Nitrate Patch Use as Treatment of Knee AVN
Status: TERMINATED
Conditions: Necrosis, Avascular, of Bone
Interventions: DRUG: nitrate patch|DRUG: placebo patch|DEVICE: MRI scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Efficacy of an Investigational Drug and Dietary Supplement in Men and Postmenopausal Women With Osteoporosis (0217A-227)
Status: COMPLETED
Conditions: Osteoporosis|Vitamin D Deficiency
Interventions: DRUG: MK0217A, alendronate sodium (+) cholecalciferol / Duration of Treatment: 15 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Vonoprazan vs Omeprazole as Empiric Therapy for Gastroesophageal Reflux Disease (GERD) Patients Without Alarm Features
Status: TERMINATED
Conditions: GERD|Gastro Esophageal Reflux
Interventions: DRUG: Vonoprazan|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Methotrexate Treatment of Arthritis Caused by Chikungunya Virus (MARCH)
Status: ENROLLING_BY_INVITATION
Conditions: Investigate the Effect(s) of Methotrexate Treatment on Arthritis Disease Severity
Interventions: DRUG: Methotrexate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acne Treatment With Active Oplon's Patches - 15-18 Years Old
Status: UNKNOWN
Conditions: Acne Vulgaris
Interventions: DEVICE: Oplon Active Patch|DEVICE: Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Treatment of the Buried Bumper Syndrome: Comparison of the Flamingo Device Versus Standard Therapy
Status: COMPLETED
Conditions: Buried Bumper Syndrome
Interventions: DEVICE: Flamingo Device|PROCEDURE: Standard Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Change in Exercise Capacity as Measured by Peak Oxygen Uptake After CTO PCI
Status: TERMINATED
Conditions: Coronary Artery Disease|Angina Pectoris
Interventions: PROCEDURE: Percutaneous Coronary Intervention|DEVICE: Coronary stent|DRUG: Clopidogrel
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: GSK Drug Single Dose Escalation And Their Effect On Resting Motor Threshold In Healthy Volunteers
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: GSK drug|OTHER: Placebo|OTHER: Lamictal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CPAP Therapy in Patients With Heart Failure and Obstructive Sleep Apnea.
Status: COMPLETED
Conditions: Heart Failure|Obstructive Sleep Apnea
Interventions: OTHER: Positron Emission Tomography|OTHER: Positron Emission Tomography|OTHER: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Stigma Toward Mental Illness and Substance Use Issues in Primary Health Care in Chile
Status: RECRUITING
Conditions: Mental Health|Substance Abuse|Stigmatization
Interventions: OTHER: Developing teams of Local Leaders|OTHER: Analysis of Internal Policies, Procedures and Protocols|OTHER: Raising Awareness|OTHER: Innovative Contact-Based Education|OTHER: Recovery-Based Arts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Multi-Reader Multi-Case Controlled Clinical Trial to Assess the Fujifilm FFDM and DBT Reader Training Program
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DEVICE: FFDM Plus DBT|DEVICE: FFDM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prolgolimab Monotherapy or in Combination With Bendamustine for r/r Classical Hodgkin Lymphoma
Status: RECRUITING
Conditions: Hodgkin Lymphoma
Interventions: DRUG: Prolgolimab|DRUG: Combination with prolgolimab and bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunological Variables Associated to ICI Toxicity in Cancer Patients
Status: RECRUITING
Conditions: Breast Cancer|Melanoma|Non Small Cell Lung Cancer|Non-melanoma Skin Cancer|Gastrointestinal Cancer|Head and Neck Cancer|Renal Cell Carcinoma|Small Cell Lung Cancer|Mesothelioma, Malignant|Bladder Cancer|Merkel Cell Carcinoma|Hepatocellular Carcinoma|MSI-H Colorectal Cancer
Interventions: DRUG: Checkpoint Blockade, Immune
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Foot Orthoses on the Braking Response Time
Status: COMPLETED
Conditions: Hallux Valgus
Interventions: DEVICE: Hallux valgus Shoe|DEVICE: Forefoot relief shoe|DEVICE: Retail Shoe
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Oral PF614 Relative to OxyContin
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: PF614|DRUG: Naltrexone Hydrochloride|DRUG: OxyContin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Characterize the Pharmacokinetics and Tolerability of Buprenorphine Patches in Children With Moderate to Severe Mouth Pain
Status: TERMINATED
Conditions: Chemotherapy Induced Mucositis|Mouth Pain
Interventions: DRUG: Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Hypomethylating Drug Guadecitabine (SGI-110) Plus Cisplatin in Relapsed Refractory Germ Cell Tumors
Status: COMPLETED
Conditions: Germ Cell Tumor|Testis Cancer|Testicular Cancer
Interventions: DRUG: Guadecitabine (SGI-110)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deep Versus Moderate Neuromuscular Blockade in Bariatric Surgery
Status: NOT_YET_RECRUITING
Conditions: Neuromuscular Blockade
Interventions: DRUG: Deep neuromascular blockage|DRUG: Moderate neuromascular blockage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SRMA of the Effect of Soy Milk vs Cow's Milk on Cardiometabolic Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases|Lipid Disorder|Metabolic Disease|Non-Alcoholic Fatty Liver Disease
Interventions: OTHER: Soy milk
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Effectiveness of STYLAGE® L for Correction of Moderate and Severe Nasolabial Folds in Chinese Adults
Status: COMPLETED
Conditions: Aging|Skin Wrinkling
Interventions: DEVICE: STYLAGE® L|DEVICE: Active Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Radiation Therapy Plus Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy for Treatment of Metastatic, Recurrent Hormone-Sensitive Prostate Cancer, DIVINE Trial
Status: RECRUITING
Conditions: Recurrent Castration-Sensitive Prostate Carcinoma|Stage IVB Prostate Cancer AJCC v8|Recurrent Prostate Cancer|Castration-resistant Prostate Cancer
Interventions: DRUG: Abiraterone|DRUG: Apalutamide|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|DRUG: Darolutamide|DRUG: Degarelix|DRUG: Enzalutamide|DRUG: Goserelin|DRUG: Histrelin|DRUG: Leuprolide|PROCEDURE: Magnetic Resonance Imaging|OTHER: Patient Observation|PROCEDURE: Positron Emission Tomography|DRUG: Prednisone|OTHER: Questionnaire Administration|DRUG: Relugolix|RADIATION: Stereotactic Body Radiation Therapy|DRUG: Triptorelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Method of Fish Oil Administration on Patient Compliance
Status: COMPLETED
Conditions: Adverse Effects
Interventions: DIETARY_SUPPLEMENT: Frozen capsule|DIETARY_SUPPLEMENT: Capsule with food|DIETARY_SUPPLEMENT: Capsule without food|DIETARY_SUPPLEMENT: Capsule with milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Effect of Prophylactic Tranexamic Acid on Bleeding Outcomes for Dilation and Evacuation
Status: COMPLETED
Conditions: Abortion|Dilation and Evacuation|Hemorrhage|Blood Loss
Interventions: DRUG: Tranexamic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Mutations in T2DM Susceptibility Genes on the Expression of Susceptibility Genes in Patients With T2DM and Controls
Status: RECRUITING
Conditions: Type 2 Diabetes Mellitus|Gene Polymorphisms|Genetic Mutations|Susceptibility, Genetic
Interventions: DRUG: Fresh normal pancreatic tissues or adjacent tissues of pancreatic cancer were collected from controls and T2DM patients without hypoglycemic drugs|DRUG: Fresh blood samples were collected from healthy subjects and T2DM patients without hypoglycemic drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Evaluation to Assess the Safety and Efficacy of GentleMax Pro Plus
Status: COMPLETED
Conditions: Pseudofolliculitis Barbae|Unwanted Hair|Pigmented Lesions|Vascular Lesion|Onychomycosis|Wrinkle|Acne
Interventions: DEVICE: GentleMax Pro Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AMD3100 (Plerixafor) Given to NHL and MM Patients to Increase the Number of PBSCs When Given a Mobilizing Regimen of G-CSF
Status: COMPLETED
Conditions: Multiple Myeloma|Lymphoma, Non-Hodgkin
Interventions: DRUG: G-CSF Plus Plerixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Paracervical Block in Laparoscopic Myomectomy: a Randomized Controlled Trial (PALM)
Status: UNKNOWN
Conditions: Uterine Fibroid
Interventions: DEVICE: Paracervical block|DRUG: 5% bupivacaine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Preoperative Dental Screening in Reducing Infective Endocarditis Risk in Transcatheter Aortic Valve Implantation Patients
Status: RECRUITING
Conditions: Transcatheter Aortic Valve Implantation|Dental|Endocarditis
Interventions: PROCEDURE: No preoperative dental screening
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: In Situ Caries Model of Fluoride Toothpastes
Status: COMPLETED
Conditions: Caries
Interventions: DRUG: Sodium Fluoride Toothpaste|DRUG: Amine Fluoride Toothpaste|DRUG: Sodium monofluorophosphate/Sodium Fluoride Toothpaste|DRUG: Placebo|DRUG: 675 ppmf toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Oral LY317615 in Relapsed or Refractory Diffuse Large B-Cell Lymphomas.
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: LY317615
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study Of PI3K/mTOR Inhibitors In Combination With An Oral MEK Inhibitor Or Irinotecan In Patients With Advanced Cancer
Status: TERMINATED
Conditions: Advanced Cancer
Interventions: DRUG: PF-05212384|DRUG: PD-0325901|DRUG: PF-05212384|DRUG: irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Combined Treatment by Botulinum Toxin and Lokomat® on Walking Ability in Chronic Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Robotic walking rehabilitation by Lokomat®|OTHER: Conventional walking rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Immunological Effects of Vitamin D Replacement Among Black/African American Prostate Cancer Patients
Status: RECRUITING
Conditions: Localized Prostate Carcinoma|Stage IV Prostate Cancer AJCC v8
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol|OTHER: Quality-of-Life Assessment|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bendamustine and Rituximab Followed by 90-yttrium (Y) Ibritumomab Tiuxetan for Untreated Follicular Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Follicular
Interventions: DRUG: Bendamustine|DRUG: Rituximab|RADIATION: Y-90 ibritumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimising Adverse Drug Reactions and Verifying Economic Legitimacy in Children (MARVEL-PIC)
Status: RECRUITING
Conditions: Neoplasms|Bone Marrow Transplantation
Interventions: DIAGNOSTIC_TEST: Release of Extended Pharmacogenomics Report at Week 1|DIAGNOSTIC_TEST: Release of Extended Pharmacogenomics Report at Week 13
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase I/II Study of Neoadjuvant Chemoradiotherapy With S-1/ Oxaliplatin in Patients With Gastric Cancer: Randomized Phase II Study of S-1/RT vs. S-1/Oxaliplatin/RT
Status: TERMINATED
Conditions: Phase I: To Determine the Maximum Tolerated Dose (MTD)|Phase II: To Assess the Pathologic CR Rate and Feasibility Following Neoadjuvant Chemoradiation Therapy With S1/Oxaliplatin
Interventions: DRUG: Oxaliplatin, S-1, radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nasal High Flow Therapy for the Treatment of Respiratory Insufficiencies During Sleep
Status: TERMINATED
Conditions: Sleep Disordered Breathing|Congestive Heart Failure
Interventions: DEVICE: Nasal High flow therapy device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Autologous Stem Cell Transplant for Neurologic Autoimmune Diseases
Status: ACTIVE_NOT_RECRUITING
Conditions: Autoimmune Disease|Neurologic Autoimmune Disease|Autologous Transplant Autoimmune|Multiple Sclerosis Transplant|MS Stem Cell Transplant|Multiple Sclerosis Stem Cell Transplant|Stiff Person Syndrome|HCT for Neurologic Autoimmune Disorders|CIDP Transplant|Myasthenia Gravis Transplant|Autoimmune Nervous System Disorder|Central Nervous System Vasculitis|Cerebellar Degeneration|Chronic Inflammatory Demyelinating Polyneuropathy|Lambert Eaton Myasthenic Syndrome|Myasthenia Gravis|Neuromyelitis Optica|Opsoclonus Myoclonus Syndrome|Rasmussen Subacute Encephalitis
Interventions: BIOLOGICAL: Anti-Thymocyte Globulin|PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation|DRUG: Carmustine|DRUG: Cytarabine|DRUG: Etoposide|OTHER: Laboratory Biomarker Analysis|DRUG: Melphalan|PROCEDURE: Peripheral Blood Stem Cell Transplantation|DRUG: Prednisone|PROCEDURE: Syngeneic Bone Marrow Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Efficacy of the Indigo® Aspiration System in Acute Pulmonary Embolism
Status: COMPLETED
Conditions: Pulmonary Embolism
Interventions: DEVICE: Indigo Aspiration System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mother-infant Bonding in the Brain: a Mindfulness-based Intervention
Status: RECRUITING
Conditions: Postpartum Depression|Postpartum Anxiety|Parental Stress
Interventions: BEHAVIORAL: "Mindful with your Baby" group-based therapist-guided intervention|BEHAVIORAL: "Mindful with your baby" self-guided online intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study To Evaluate Safety, Tolerability And Pharmacokinetic Comparability Of Pegvisomant 1 X 30 Mg Vs 2 X 15 Mg Subcutaneously Administered In Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: 1 x 30 mg/mL pegvisomant|DRUG: 2 x 15 mg/mL pegvisomant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: 211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome
Status: SUSPENDED
Conditions: Acute Lymphoblastic Leukemia in Remission|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Acute Myeloid Leukemia in Remission|Chronic Myelomonocytic Leukemia|Myelodysplastic Syndrome With Excess Blasts|Recurrent Acute Lymphoblastic Leukemia|Recurrent Acute Myeloid Leukemia|Refractory Acute Lymphoblastic Leukemia|Refractory Acute Myeloid Leukemia|Recurrent Mixed Phenotype Acute Leukemia|Refractory Mixed Phenotype Acute Leukemia|Hematopoietic and Lymphoid Cell Neoplasm
Interventions: BIOLOGICAL: Astatine At 211 Anti-CD45 Monoclonal Antibody BC8-B10|DRUG: Cyclophosphamide|RADIATION: Total-Body Irradiation|PROCEDURE: Peripheral Blood Stem Cell Transplantation|PROCEDURE: Bone Marrow Transplantation|DRUG: Mycophenolate Mofetil|BIOLOGICAL: Recombinant Granulocyte Colony-Stimulating Factor|DRUG: Fludarabine Phosphate|DRUG: Tacrolimus|PROCEDURE: Bone Marrow Aspiration and Biopsy|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating User Satisfaction and Feasibility of a Remote Model for 3d Scanned and Printed Transtibial Prosthetic Sockets
Status: COMPLETED
Conditions: Amputation|Prosthesis User
Interventions: DEVICE: 3d printed prosthetic socket
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion
Status: RECRUITING
Conditions: Acute Leukemia|Severe Aplastic Anemia|Non-hodgkin Lymphoma|Hodgkin Lymphoma|Kostmann|Diamond Blackfan Anemia|Amegakaryocytic Thrombocytopenia|Sickle Cell Disease|Beta-Thalassemia
Interventions: DRUG: alpha beta depletion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Swiss 2024 Continous Fever Monitoring in Pediatric Oncology Patients
Status: NOT_YET_RECRUITING
Conditions: Pediatric Oncology Patients With Risk for Infections
Interventions: OTHER: Automated fever alerts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Substantiation and Standardization of the Multimodal Cognitive-motor Rehabilitation System for Afterstroke Patients
Status: RECRUITING
Conditions: Stroke Rehabilitation
Interventions: PROCEDURE: Multimodal technology (MT)|PROCEDURE: Conventional rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Thoracic Ultrasound in Monitoring Pleural Drainage in Postoperative Thoracic Surgery
Status: COMPLETED
Conditions: Thoracic Ultrasound|Pleural Drain Removal
Interventions: PROCEDURE: Thoracic ultrasound versus chest X-ray
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Efficacy of a Single Dose of Intranasal Oxytocin in the Prevention of Post Traumatic Stress Disorder (PTSD)
Status: UNKNOWN
Conditions: Stress Disorders, Post-Traumatic
Interventions: DRUG: Oxytocin|DRUG: placebo - saline nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multi-centre Study to Assess the Long-term Performance of the Deltamotion Cup System in Primary Hip Replacement Surgery
Status: TERMINATED
Conditions: Rheumatoid Arthritis|Osteoarthritis|Post-traumatic Arthritis|Avascular Necrosis|Traumatic Femoral Fractures|Congenital Hip Dysplasia
Interventions: DEVICE: Delta Motion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Catheter Directed Thrombolysis for Acute Pulmonary Embolism
Status: UNKNOWN
Conditions: Pulmonary Embolism
Interventions: DRUG: Low dose alteplase|DRUG: Unfractionated heparin|DEVICE: Infusion catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study on the Efficacy of AI Temperature-controlled Radiofrequency Technology and Electrical Stimulation in the Treatment of Vulvar Leukoplakia
Status: RECRUITING
Conditions: Vulvar Lichen Sclerosus
Interventions: PROCEDURE: Radiofrequency technology|PROCEDURE: Electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Single-dose and Steady-state TPV/RTV on the Steady-state Pharmacokinetics of Fluconazole in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tipranavir (TPV)|DRUG: Ritonavir (RTV)|DRUG: Fluconazole (FCZ)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NICU Antibiotics and Outcomes Trial
Status: RECRUITING
Conditions: Microbial Colonization|Extreme Prematurity|Early-Onset Neonatal Sepsis|Late-Onset Neonatal Sepsis|Necrotizing Enterocolitis of Newborn|Death; Neonatal
Interventions: DRUG: Ampicillin|DRUG: Gentamycin|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Consequences of CPT-1 Deficiency
Status: COMPLETED
Conditions: Carnitine Palmitoyl Transferase Type 1A (CPT1A) Deficiency
Interventions: OTHER: Medically supervised fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Macintosh Laryngoscope Assisted Fiberoptic Intubation
Status: COMPLETED
Conditions: Difficult Intubation
Interventions: DEVICE: fiberoptic, airway|DEVICE: fiberoptic, Machintosh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study Of The Effectiveness And Safety Of A 36-Week Refill Regimen For The Port Delivery System With Ranibizumab Vs Aflibercept Treat & Extend In Subjects With Neovascular Age-Related Macular Degeneration
Status: WITHDRAWN
Conditions: Neovascular Age-Related Macular Degeneration
Interventions: DRUG: Ranibizumab|DRUG: Aflibercept|DEVICE: Port Delivery System with ranibizumab (PDS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Early Laparoscopy With Active Observation in Acute Non-specific Abdominal Pain
Status: TERMINATED
Conditions: Non-specific Abdominal Pain
Interventions: PROCEDURE: early laparoscopy|PROCEDURE: General anaesthesia|DEVICE: Laparoscopic instruments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Everolimus Treatment of Refractory Epilepsy
Status: RECRUITING
Conditions: Epilepsy
Interventions: DRUG: Everolimus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telemonitoring of Pregnancies Complicated With Gestational Diabetes Mellitus.
Status: RECRUITING
Conditions: Gestational Diabetes|Telemonitoring
Interventions: DEVICE: iHealth Gluco-Smart application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Bioequivalence Study on Two Lisinopril Tablets 20mg Formulations
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: BF-Lisinopril Tablets 20mg|DRUG: Zestril Tab 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prevention of Hypoglycaemia by Oral 40% Destrogel
Status: COMPLETED
Conditions: Hypoglycaemia Neonatal
Interventions: DIETARY_SUPPLEMENT: Administration of a placebo solution (0.5 ml / kg)|DIETARY_SUPPLEMENT: Administration of a placebo solution (1 ml / kg)|DIETARY_SUPPLEMENT: Administration of 40% glucose in gel (0.5 ml / Kg)|DIETARY_SUPPLEMENT: Administration of 40% glucose in gel 1 ml / Kg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Buccal Fat Pad Derived Stem Cells With Cortical Tenting in Posterior Mandible Reconstruction
Status: UNKNOWN
Conditions: Alveolar Bone Loss|Atrophy
Interventions: PROCEDURE: BFPSC+FDBA+PRF|PROCEDURE: FDBA+PRF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Teaching Inhaler Use With the INCA Device in a Community Pharmacy Setting
Status: COMPLETED
Conditions: Asthma|Pulmonary Disease, Chronic Obstructive
Interventions: DEVICE: Feedback|BEHAVIORAL: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Glycaemic Index of Fibre-rich Flours in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Standard white bread|OTHER: Experimental white bread|OTHER: Standard High-fiber bread|OTHER: Experimental High-fiber bread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Rivastigmine Patch on Activities of Daily Living and Cognition in Patients With Severe Dementia of the Alzheimer's Type (ACTION) (Study Protocol CENA713DUS44, NCT00948766) and a 24 Week Open-label Extension to Study CENA713DUS44
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Rivastigmine 4.6 mg/24 h (5 cm^2)|DRUG: Rivastigmine 9.5 mg/24 h (10 cm^2)|DRUG: Rivastigmine 13.3 mg/24 h (15 cm^2)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laryngeal Injuries After Removal of the Tracheal Tube: A Comparison Between Sevoflurane and Propofol
Status: COMPLETED
Conditions: Vocal Cord; Injury, Superficial
Interventions: DRUG: Sevoflurane|DRUG: propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multi-user Touch Surfaces for Promoting Social Participation and Self-efficacy in Upper-limb Stroke Rehabilitation
Status: COMPLETED
Conditions: Social Interaction|Self Efficacy|Stroke|Motor Activity
Interventions: OTHER: Physical rehabilitation|OTHER: Physical rehabilitation interactive table
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ATOMIC (Active Teens Multiple Sclerosis) Physical Activity Research Program
Status: UNKNOWN
Conditions: Pediatric Multiple Sclerosis
Interventions: BEHAVIORAL: Physical Activity (PA) Intervention|BEHAVIORAL: Waitlist attention-control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Nusinersen (BIIB058) in Participants With Spinal Muscular Atrophy
Status: COMPLETED
Conditions: Muscular Atrophy, Spinal
Interventions: DRUG: Nusinersen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effects of Harvoni in Patients With Decompensated Cirrhosis Due to Hepatitis C Genotype 1 Infection
Status: COMPLETED
Conditions: Hepatitis C, Chronic|Cirrhosis, Decompensated
Interventions: DRUG: Ledipasvir/Sofosbuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Care With Breast Milk in Preterm Newborns Fed by Tube
Status: COMPLETED
Conditions: Breastmilk|Oral Care
Interventions: OTHER: oral care with breastmilk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: MRI Study of the Mechanisms Underlying Irreversible Disability in Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis
Interventions: OTHER: MRI 3T|OTHER: MRI 1,5T|OTHER: MRI 7T
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Use of Electroconvulsive Therapy to Treat Self-Injurious Behavior in Adults With Autism Spectrum Disorders
Status: TERMINATED
Conditions: Autism Spectrum Disorder|Self-Injurious Behavior
Interventions: DEVICE: Electroconvulsive Therapy (ECT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduction of Environmental Tobacco Smoke (ETS) Exposure In Pediatric Cancer Patients
Status: COMPLETED
Conditions: Cancer
Interventions: BEHAVIORAL: Health Risk and Behavioral Skills Coaching Sessions|BEHAVIORAL: Telephone Coaching Sessions|BEHAVIORAL: Physician Feedback Letter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Digital Therapeutic for Adolescent Depressive Symptoms in Hematology, Oncology, and Weight Management
Status: TERMINATED
Conditions: Depression|Depressive Disorder|Depressive Symptoms|Depressive Episode|Adolescent Behavior|Adolescent - Emotional Problem|Hematologic Diseases|Oncology|Weight, Body
Interventions: DEVICE: CBT-based mobile intervention for depression|DEVICE: Mobile control with education about depression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Treatment Perspectives in Adolescents With Anorexia Nervosa: the Efficacy of Non-invasive Brain-directed Treatment
Status: RECRUITING
Conditions: Anorexia in Adolescence
Interventions: DEVICE: AN Active tDCS|DEVICE: AN Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PROCHYMAL® (Human Adult Stem Cells) for the Treatment of Recently Diagnosed Type 1 Diabetes Mellitus (T1DM)
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus|Type 1 Diabetes|Diabetes Mellitus, Insulin-Dependent|Juvenile Diabetes
Interventions: DRUG: PROCHYMAL®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase Ⅲ Study to Evaluate Tildrakizumab in the Treatment of Chinese Subjects With Moderate to Severe Plaquetype Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Tildrakizumab 100 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vorinostat, Fluorouracil, and Leucovorin Calcium in Treating Patients With Metastatic Colorectal Cancer That Has Not Responded to Previous Treatment
Status: COMPLETED
Conditions: Adenocarcinoma of the Colon|Adenocarcinoma of the Rectum|Recurrent Colon Cancer|Recurrent Rectal Cancer|Stage IV Colon Cancer|Stage IV Rectal Cancer
Interventions: DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: vorinostat|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Rifabutin Combined With Antiretroviral Therapy in Patients With TB/HIV Co-infection in Vietnam
Status: COMPLETED
Conditions: HIV Infections|Tuberculosis
Interventions: DRUG: rifabutin in combination with lopinavir boosted by ritonavir - dosing schedule 1|DRUG: rifabutin in combination with lopinavir boosted by ritonavir - dosing schedule 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of PRV-3279 in Healthy Subjects
Status: COMPLETED
Conditions: Safety
Interventions: BIOLOGICAL: PRV-3279 or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Combination Chemotherapy of DCS (Cisplatin + Docetaxel + S-1) and DCF (Docetaxel + Cisplatin + 5-FU) in Patients With Locally Advanced Gastric Adenocarcinoma
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: DCS (docetaxel with cisplatin with TS-1)|DRUG: DCF (docetaxel with cisplatin with 5-FU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nicardipine Versus Labetalol During Intubation
Status: UNKNOWN
Conditions: Patients Who Are Intubated for General Anesthesia|Endotracheal Intubation
Interventions: DRUG: labetalol|DRUG: nicardipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ayurvedic Herbs in Diarrhea Predominant Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Ayurvedic Herbs|DRUG: Placebo tea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Citicoline Effects on Cortical Membrane Structure and Function
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Citicoline supplement|DIETARY_SUPPLEMENT: Placebo supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Multiple Dose Study Of PF-05161704 In Healthy Volunteers
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: PF-05161704 or Placebo|DRUG: PF-05161704 or Placebo|DRUG: PF-05161704 or Placebo|DRUG: PF-05161704 or Placebo|DRUG: PF-05161704 or Placebo|DRUG: PF-05161704 or Placebo|DRUG: PF-05161704 or Placebo|DRUG: PF-05161704 or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess the Efficacy and Safety of Nemolizumab (CD14152) in Participants With Prurigo Nodularis (PN)
Status: COMPLETED
Conditions: Prurigo Nodularis
Interventions: DRUG: Nemolizumab 30 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optical Biopsy of Human Skin in Conjunction With Laser Treatment
Status: COMPLETED
Conditions: Malignant Melanoma|Merkel Cell Carcinoma|Basal Cell Carcinoma|Squamous Cell Carcinoma|Atypical Nevi|Congenital Nevi|Seborrheic Keratosis|Paget's Disease|Dermatofibroma|Kaposi's Sarcoma|Port Wine Stain|Hemangioma|Tattoos|Scleroderma|Burns
Interventions: DEVICE: Optical Biopsy imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety & Performance Study of the FANTOM Sirolimus-Eluting Bioresorbable Coronary Scaffold
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: Fantom Sirolimus-Eluting Coronary Bioresorbable Scaffold
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Isoflavone Treatment for Postmenopausal Osteopenia.
Status: COMPLETED
Conditions: Osteopenia|Osteoporosis
Interventions: DIETARY_SUPPLEMENT: Red clover extract|DIETARY_SUPPLEMENT: Supplementation (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IINB vs. QLB for Elective Open Inguinal Herniorrhaphy
Status: COMPLETED
Conditions: Nerve Block|Herniorrhaphy|Regional Anesthesia
Interventions: PROCEDURE: Ilioinguinal / Iliohypogastric Block|PROCEDURE: Quadratus Lumborum Block|DRUG: Bupivacaine 0.25%|DRUG: Epinephrine 1:200k|DRUG: Clonidine 1.66mcg/cc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injection for Postoperative Pain Following Total Hip Arthroplasty.
Status: COMPLETED
Conditions: Post-Operative Pain
Interventions: DRUG: VVZ-149 injections|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Safety and Efficacy of Bone Marrow Derived Autologous Cells for the Treatment of Muscular Dystrophy.
Status: UNKNOWN
Conditions: Muscular Dystrophy|Duchenne Muscular Dystrophy,
Interventions: BIOLOGICAL: Stem Cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adebrelimab Combined With Fluzoparib in HRD-positive HR +/HER2- Advanced Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Female Breast Cancer Patients|Histopathologically Confirmed Advanced HR +/HER2-invasive Breast Cancer|HRD Positive Advanced Breast Cancer
Interventions: DRUG: Adebrelimab plus Fluzoparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures
Status: COMPLETED
Conditions: Drug Effect|Rib Fractures|Rib Trauma|Surgical Procedure, Unspecified|Pain; Catheter (Other)|Nerve Pain|Local Infiltration|Anesthesia, Local|Intercostal Rib|Opioid Dependence|Chest Injury Trauma|Pneumonia
Interventions: DRUG: Liposomal bupivacaine injection|DRUG: Bupivacaine indwelling catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Efficacy of HUDC_VT in Patients With Bacterial Vaginosis
Status: UNKNOWN
Conditions: Bacterial Vaginosis|HUDC_VT|Haudongchun
Interventions: DRUG: HUDC_VT(Glucose 200mg/Sodium chloride 200mg)|DRUG: HUDC_VT (Glucose 400mg/Sodium chloride 200mg)|DRUG: HUDC_VT (Glucose 400mg)|DRUG: HUDC_VT (Sodium chloride 200mg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Postpartum Adaptation Study of the Connecting and Reflecting Experience Parenting Program
Status: RECRUITING
Conditions: Postpartum Depression|Postpartum Anxiety|Parenting Stress|Parent Child Relationships
Interventions: BEHAVIORAL: Connecting and Reflecting Experience (CARE) Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laboratory Study of Lymphoblasts in Young Patients With High-Risk Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: GENETIC: loss of heterozygosity analysis|GENETIC: microarray analysis|GENETIC: polymorphism analysis|GENETIC: tumor replication error analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Placebo Controlled Trial of a Titanium Dioxide Semiconductor Toothbrush on Mild-to-moderate Gum Disease
Status: COMPLETED
Conditions: Periodontal Diseases
Interventions: DEVICE: Soladey-3 toothbrush|DEVICE: Placebo Soladey-3 toothbrush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Breakthrough Dyspnea Fentanyl Study in Cancer Patients
Status: COMPLETED
Conditions: Advanced Cancers|Dyspnea
Interventions: DRUG: Fentanyl|OTHER: Placebo|OTHER: Walking Tests|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prospective Study of Deep Anterior Lamellar Keratoplasty Using Acellular Porcine Cornea
Status: UNKNOWN
Conditions: Corneal Transplantation
Interventions: PROCEDURE: Deep anterior lamellar keratoplasty|DEVICE: Acellular Porcine Cornea|DRUG: Tacrolimus eye drops|DRUG: Tobradex eyedrops
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Liraglutide in Obese Subjects With Moderate or Severe Obstructive Sleep Apnoea: SCALE™ - Sleep Apnoea
Status: COMPLETED
Conditions: Metabolism and Nutrition Disorder|Obesity|Obstructive Sleep Apnoea
Interventions: DRUG: liraglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: "Effects of Kinesio Taping in Adjunct to Traditional Physical Therapy on Pain, Range of Motion and Gait Parameters in Patients With Plantar Fasciitis : a Randomized Controlled Trail"
Status: RECRUITING
Conditions: Plantar Fascitis
Interventions: OTHER: Traditional Physical Therapy|OTHER: Kinesiotaping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Testing a New Immune Cell Therapy, GD2-Targeted Modified T-cells (GD2CART), in Children, Adolescents, and Young Adults With Relapsed/Refractory Osteosarcoma and Neuroblastoma, The GD2-CAR PERSIST Trial
Status: RECRUITING
Conditions: Recurrent Childhood Neuroblastoma|Recurrent Childhood Osteosarcoma|Recurrent Neuroblastoma|Recurrent Osteosarcoma|Refractory Childhood Neuroblastoma|Refractory Childhood Osteosarcoma|Refractory Neuroblastoma|Refractory Osteosarcoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|DRUG: Cyclophosphamide|PROCEDURE: Echocardiography|DRUG: Fludarabine Phosphate|BIOLOGICAL: GD2-CAR-expressing Autologous T-lymphocytes|PROCEDURE: Imaging Procedure|PROCEDURE: Magnetic Resonance Imaging of the Heart|PROCEDURE: Multigated Acquisition Scan|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SRS for NSCLC With Oligo-residual Intracranial Disease After First-line 3rd Generation EGFR-TKI
Status: RECRUITING
Conditions: Brain Metastases|Non-small Cell Lung Cancer
Interventions: DRUG: EGFR-TK Inhibitor|RADIATION: Stereotactic radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Comparison of Efficacy and Safety of High-intensity Rosuvastatin/Ezetimibe Combination Versus Treat-to-target Rosuvastatin Monotherapy for Patients With Peripheral Artery or Polyvascular Disease (CARE-PVD Trial)
Status: RECRUITING
Conditions: Peripheral Artery Disease|Polyvascular Disease
Interventions: DRUG: Combination therapy of high-intensity dose rosuvastatin and ezetimibe|DRUG: Rosuvastatin monotherapy for treat-to-target
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study of UX003 Recombinant Human Betaglucuronidase (rhGUS) Enzyme Replacement Therapy in Patients With Mucopolysaccharidosis Type 7 (MPS 7)
Status: COMPLETED
Conditions: MPS 7|Sly Syndrome|Mucopolysaccharidosis|MPS VII
Interventions: DRUG: UX003|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT