pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase 1 Trial of RP-3467 Alone and in Combination With Olaparib in Participants With Advanced Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: RP-3467 at assigned dose and schedule|DRUG: Olaparib 200-300 mg BID, daily
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Presumptively Initiating Vaccines and Optimizing Talk With Motivational Interviewing (PIVOT With MI)
Status: ACTIVE_NOT_RECRUITING
Conditions: Preventive Health Services (PREV HEALTH SERV)
Interventions: BEHAVIORAL: Experimental: PIVOT with MI|OTHER: Active Comparator: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Milk Protein and Vitamin D on Children's Growth and Health
Status: COMPLETED
Conditions: Bone Health|Muscle Function|Cardiometabolic Health|Appetite Regulation
Interventions: DIETARY_SUPPLEMENT: Milk Protein (high)|DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: Milk Protein (medium)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Tasimelteon Compared With Placebo in Totally Blind Subjects With Non-24-Hour Sleep-Wake Disorder
Status: COMPLETED
Conditions: Non-24-Hour Sleep-Wake Disorder
Interventions: DRUG: tasimelteon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Tadalafil on Cerebral Large Arteries in Stroke
Status: COMPLETED
Conditions: Stroke, Lacunar|Cerebral Small Vessel Diseases
Interventions: DRUG: Tadalafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Mindfulness-Based Stress Reduction for Patients With Persistent Cancer-Related Fatigue
Status: COMPLETED
Conditions: Cancer|Fatigue
Interventions: BEHAVIORAL: Mindfulness-Based Stress Reduction - Cancer-Related Fatigue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sunitinib Malate and Combination Chemotherapy as Front-Line Therapy in Treating Patients With Metastatic Rectal Cancer That Cannot Be Removed by Surgery
Status: WITHDRAWN
Conditions: Colorectal Cancer|Metastatic Cancer
Interventions: DRUG: FOLFIRI regimen|DRUG: fluorouracil|DRUG: irinotecan hydrochloride|DRUG: leucovorin calcium|DRUG: sunitinib malate|OTHER: laboratory biomarker analysis|OTHER: pharmacogenomic studies|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness & Tolerability of Novel, Initial Triple Combination Therapy vs Conventional Therapy in Type 2 Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type II
Interventions: DRUG: triple combination therapy|DRUG: Stepwise add-on therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Ergothioneine on Cognition, Mood, and Sleep in Healthy Adult Men and Women
Status: TERMINATED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: L-Ergothioneine 10 mg/d|DIETARY_SUPPLEMENT: L-Ergothioneine 25 mg/d|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: [18F]Fluoroestradiol-PET/CT Companion Imaging Study to the FORESEE Trial
Status: RECRUITING
Conditions: Estrogen Receptor Positive Breast Cancer
Interventions: DRUG: [18F]Fluoroestradiol (FES) PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of PROVISIONal 1-stent Strategy With DEB Versus Planned 2-stent Strategy in Coronary Bifurcation Lesions.
Status: RECRUITING
Conditions: Coronary Artery Disease|Ischemic Heart Disease
Interventions: PROCEDURE: Procedure: planed 2-stent strategy|PROCEDURE: Procedure: provisional 1-stent plus DEB strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation Study for the Alertgy Non-invasive Continuous Glucose Monitor (ANICGM)
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DEVICE: Alertgy non-invasive continuous glucose monitoring device (ANICGM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Collagen-targeted Positron Emission Tomography (PET) Imaging for Assessment of EGCG Effect
Status: RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: EGCG 300 mg|DRUG: Placebo for EGCG 300 mg|DRUG: EGCG 600 mg|DRUG: Placebo for EGCG 600 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assess the Effect of Dehydroepiandrosterone (DHEA) or Other Androgenic Agents Over Markers of Ovarian Reserve
Status: COMPLETED
Conditions: Healthy Women|Infertility, Female
Interventions: DRUG: DHEA|DRUG: Another Androgenic Agent (VRaA)|DRUG: Fixed combination of 2 androgenic agents (VR2A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hyperthermic Intraperitoneal Chemotherapy With Paclitaxel in Advanced Ovarian Cancer
Status: UNKNOWN
Conditions: Epithelial Ovarian Cancer
Interventions: DRUG: HIPEC|PROCEDURE: No HIPEC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In Situ Comparison of the Remineralization Potential of Optimized Fluoride Dentifrice With Control Fluoride Dentifrice
Status: COMPLETED
Conditions: Caries
Interventions: DRUG: 0 ppm F (placebo, negative control)|DRUG: 1100 ppm F as sodium fluoride (positive control)|DRUG: 1100 ppm F as sodium fluoride Test Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: the Effectiveness of Therapeutic Virtual Reality Versus Pharmacological Sedation on Pain and Anxiety During Interventional Cardiology Procedures
Status: COMPLETED
Conditions: Virtual Reality|Drug Sedation|Coronarography|Angiography
Interventions: PROCEDURE: scheduled outpatient interventions in interventional cardiology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Validation of Two Measures for Growth Hormone Deficiency in Children, the Treatment Related Impact Measure of Childhood Growth Hormone Deficiency (TRIM-CGHD) and the Treatment Burden Measure of Childhood Growth Hormone Deficiency (TB-CGHD)
Status: COMPLETED
Conditions: Growth Disorder|Growth Hormone Deficiency in Children
Interventions: OTHER: No treatment given
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase II Study of Dato-DXd in Triple-negative Breast Cancer Patients With Newly Diagnosed or Progressing Brain Metastases
Status: RECRUITING
Conditions: Breast Cancer Stage IV
Interventions: DRUG: Datopotamab deruxtecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individual Dose Adjustment of Low-molecular-weight-heparin by Thromodynamics Test.
Status: UNKNOWN
Conditions: Venous Thromboembolism
Interventions: DRUG: Standard Enoxaparin 40 mg once-daily before randomization|DRUG: Standard Enoxaparin 40 mg once-daily after randomization|DRUG: Escalated Enoxaparin 30 mg twice-daily after randomization|DEVICE: Anti-embolic elastic compression stockings|DIAGNOSTIC_TEST: Thrombodynamic test (TD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A 6-Month Extension Study of VMDN-003-2 to Assess Engensis in Participants With Painful Diabetic Peripheral Neuropathy
Status: RECRUITING
Conditions: Diabetic Peripheral Neuropathy
Interventions: BIOLOGICAL: Engensis|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Durvalumab in Combination With Lenalidomide in Relapsed/Refractory NK-T-cell Lymphoma
Status: UNKNOWN
Conditions: LYMPHOMA
Interventions: DRUG: Durvalumab|DRUG: Lenali
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bendamustine Versus Fludarabine in Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: bendamustine|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Getting Real About The Talk (GReAT) Project - A Qualitative, Patient-Centered Evaluation of the Factors for Successfully Having 'The Talk' and Implementation for Attending and Trainee Physicians
Status: UNKNOWN
Conditions: Self Efficacy
Interventions: BEHAVIORAL: Violence Prevention Conversation Script to Discuss Safely Navigating Police Encounters
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease
Status: NOT_YET_RECRUITING
Conditions: Alzheimer Disease|Mild Cognitive Impairment
Interventions: DEVICE: tACS device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intravesical B.C.G and Gemcitabine on Semen Quality and Testicular Volume
Status: NOT_YET_RECRUITING
Conditions: Urothelial Carcinoma Bladder|Sperm Count, Low|Testis; Fibrosis
Interventions: BIOLOGICAL: Bacillus Calmette Guerin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Development and Testing of a Tele-rehabilitation System for Adult Patients With Knee Osteoarthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee Osteoarthritis|Knee Osteoarthritis \(OA\)|Telerehabilitation
Interventions: OTHER: group A: in face to face live therapeutic exercise|OTHER: group B: telerehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Intra Auricular Device as a Treatment for Painful Temporo-Mandibular Disorders
Status: COMPLETED
Conditions: Temporomandibular Disorder|Pain|Psychosocial Impairment|Myofascial Pain
Interventions: DEVICE: Intra auricular device (IAD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of the Meaning-Making Intervention (MMi) In Newly Diagnosed Advanced Cancer
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: DRUG: Meaning-Making intervention (MMi)|BEHAVIORAL: Empathic Visitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Qi-tonifying Chinese Herbal Products for Treatment of Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Qi-tonifying Chinese herbal products
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Zilucoplan in Subjects With Immune-Mediated Necrotizing Myopathy
Status: TERMINATED
Conditions: Immune Mediated Necrotizing Myopathy
Interventions: DRUG: zilucoplan|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modufolin (Arfolitixorin) in Combination With 5-Fluorouracil Alone or Together With Oxaliplatin or Irinotecan in Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Neoplasm
Interventions: DRUG: Modufolin (arfolitixorin)|DRUG: Fluorouracil|DRUG: Oxaliplatin|DRUG: Irinotecan|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Treatment High Risk and/or Low Risk Acute Lymphoblastic leukémia(ALL) Adults Stage III
Status: COMPLETED
Conditions: Leukemia, Lymphocytic, Acute
Interventions: DRUG: interferon alpha 2a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LOL: It's All Improv After Cancer!™
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Psychological Distress
Interventions: BEHAVIORAL: Improvisational comedy classes|BEHAVIORAL: Waitlist control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Contactless Measurement of Heart Rate, Heart Rate Variability and Breathing Rate Using Remote Photoplethysmography
Status: COMPLETED
Conditions: Heart Rate|Heart Rate Variability|Respiratory Rate
Interventions: DIAGNOSTIC_TEST: measurement of physiological parameters wih Shen.AI Vitals software on various camera-equipped devices (smartphones, tablets, laptops)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Study to Evaluate the Performance of the PicoWayTM 1064 nm/ 785 nm/ 532nm Picosecond Laser for Tattoo Removal
Status: UNKNOWN
Conditions: Tattoo; Pigmentation
Interventions: DEVICE: PicoWay
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Dose Chemotherapy Plus Peripheral Stem Cell Transplantation Compared With Standard Therapy in Treating Women With Metastatic or Recurrent Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: mitoxantrone hydrochloride|DRUG: tamoxifen citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection of Small Fiber Neuropathies by the Non-invasive SUDOSCAN Method During Chronic Autoimmune Pathologies and / or Unexplained Pain Syndromes
Status: UNKNOWN
Conditions: Systemic Autoimmune Pathologies|Unexplained Pain Syndrome
Interventions: OTHER: SUDOSCAN and EMG (electromyogram)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: AeroVanc in the Treatment of Methicillin-resistant Staphylococcus Aureus Infection in Patients With Cystic Fibrosis
Status: COMPLETED
Conditions: MRSA|Cystic Fibrosis
Interventions: DRUG: Vancomycin inhalation powder|DRUG: Placebo inhalation powder|DRUG: Vancomycin inhalation powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 3D Ultrasound, Specimen Examination by Surgeon, and MRI in Surgical Margin Assessment
Status: NOT_YET_RECRUITING
Conditions: Squamous Cell Carcinoma|Tongue SCC|Head and Neck Cancer
Interventions: DIAGNOSTIC_TEST: 3D ultrasound, MRI, resected specimen examination by surgeon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study In Healthy People Of Multiple Doses Of UK-396,082 Given By Mouth, To Investigate The Safety, Toleration And Time Course Of Blood Concentration Of UK-396,082 And Its Effects.
Status: COMPLETED
Conditions: Phase 1|Multiple Dose|Safety|Toleration|Pharmacokinetic
Interventions: DRUG: UK-396,082|DRUG: placebo|DRUG: UK-396,082|DRUG: placebo|DRUG: UK-396,082|DRUG: placebo|DRUG: UK-396,082|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Investigator Initiated Randomized Open-label Comparative Study of Britomar (Prolonged Release Torasemide) and Diuver (Torasemide) to Assess Effects on Natriuresis and Central Hemodynamics.
Status: UNKNOWN
Conditions: Arterial Hypertension|Chronic Heart Failure
Interventions: DRUG: Prolonged release Torasemide (Britomar)|DRUG: Torasemide (Diuver)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-market Study to Obtain Surgeon Feedback on Clinical Outcome in Eyes Implanted With TECNIS Toric II IOL
Status: COMPLETED
Conditions: Cataract|Corneal Astigmatism
Interventions: DEVICE: TECNIS® TORIC II Intraocular Lens (IOL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study of Chloroprocaine Versus Ropivacaine for Epidural Labor Analgesia
Status: NOT_YET_RECRUITING
Conditions: Obstetric Labor
Interventions: DRUG: Chloroprocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Infacort® Versus Cortef® in Healthy Adult Male and Female Subjects
Status: COMPLETED
Conditions: Adrenal Insufficiency
Interventions: DRUG: Infacort®|DRUG: Cortef®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Artificial Intelligence Algorithm for Identifying Gynecologic Cancer Patients in Need of Outpatient Palliative Care
Status: RECRUITING
Conditions: Advanced Malignant Female Reproductive System Neoplasm
Interventions: OTHER: Electronic Health Record Review|OTHER: Internet-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Clinical Trial of Water Therapy for Autosomal Dominant Polycystic Kidney Disease
Status: COMPLETED
Conditions: Autosomal Dominant Polycystic Kidney
Interventions: OTHER: High Water Intake
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Exercise on Disease Activity in Patients With Ankylosing Spondylitis by SIRI and SII
Status: NOT_YET_RECRUITING
Conditions: Ankylosing Spondylitis
Interventions: OTHER: home-based exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Long-term Safety of Arbaclofen Extended-Release Tablets for Patients With Spasticity Due to MS
Status: COMPLETED
Conditions: Multiple Sclerosis|Spasticity, Muscle
Interventions: DRUG: Arbaclofen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Boosting Breastfeeding in Low-Income, Multi-ethnic Women: A Primary Care Based RCT
Status: COMPLETED
Conditions: Breastfeeding|Breastfeeding, Exclusive
Interventions: BEHAVIORAL: Lactation Consultant|BEHAVIORAL: Provider Prompt|BEHAVIORAL: LC+ Provider Prompt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Preliminary Effectiveness of AV650 in Patients With Spasticity Associated With Multiple Sclerosis
Status: TERMINATED
Conditions: Muscle Spasticity
Interventions: DRUG: tolperisone HCl|DRUG: tolperisone HCl|DRUG: tolperisone HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PeRiodontal Treatment to Eliminate Minority InEquality and Rural Disparities in Stroke
Status: UNKNOWN
Conditions: Periodontal Disease|Stroke|TIA
Interventions: PROCEDURE: Intensive dental treatment|PROCEDURE: Standard dental treatment|DRUG: Arestin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Administration of Anti-siglec-6 CAR-T Cell Therapy in Relapsed and Refractory Acute Myeloid Leukemia (rr/AML)
Status: RECRUITING
Conditions: Acute Myeloid Leukemia Refractory|Acute Myeloid Leukemia, in Relapse
Interventions: DRUG: anti-siglec-6 CAR-T cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Observational Study to Assess the Prevalence and Outcomes of Primary Pulmonary Coccidioidomycosis in Persons Aged > / = 14 Years Presenting With Community Acquired Pneumonia (CAP) in Endemic Areas (SAnds-PPC)
Status: COMPLETED
Conditions: Coccidioidomycosis|Pneumonia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of GLP1 Receptor Agonist on Brain Insulin Responsiveness
Status: RECRUITING
Conditions: Normal Weight|Overweight and Obesity|Insulin Sensitivity|Insulin Resistance
Interventions: OTHER: Subcutaneous GLP1-RA|OTHER: Subcutaneous placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Watchful Living in Improving Quality of Life in Participants With Localized Prostate Cancer on Active Surveillance and Their Partners
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage I Prostate Cancer AJCC v8|Stage II Prostate Cancer AJCC v8|Stage IIA Prostate Cancer AJCC v8|Stage IIB Prostate Cancer AJCC v8|Stage IIC Prostate Cancer AJCC v8|Stage III Prostate Cancer AJCC v8|Stage IIIA Prostate Cancer AJCC v8|Stage IIIB Prostate Cancer AJCC v8|Stage IIIC Prostate Cancer AJCC v8
Interventions: OTHER: Counseling|OTHER: Informational Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|BEHAVIORAL: Telephone-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mirror Therapy Combined With Contralaterally Controlled Functional Electrical Stimulation for Peripheral Nerve Injury
Status: RECRUITING
Conditions: Peripheral Nerve Injury
Interventions: BEHAVIORAL: mirror therapy|DEVICE: contralaterally controlled functional electrical stimulation|BEHAVIORAL: conventional physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Nerve Stimulation for Inhibition of Bladder Incontinence in Spinal Cord Injured Subjects.
Status: UNKNOWN
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Dermatome stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pediatric High-Risk Deep Venous Thrombosis Lytic Outcomes Trial
Status: WITHDRAWN
Conditions: Deep Vein Thrombosis|Post-Thrombotic Syndrome|Venous Thrombosis
Interventions: DRUG: Recombinant tissue plasminogen activator (rt-PA)|DRUG: Standard Anticoagulation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Niclosamide Enemas in Subjects With Active Ulcerative Proctitis or Ulcerative Proctosigmoiditis
Status: TERMINATED
Conditions: Ulcerative Colitis|Ulcerative Proctitis|Ulcerative Proctosigmoiditis
Interventions: DRUG: Niclosamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Measuring Effects of Pazopanib Hydrochloride in Patients With Metastatic Kidney Cancer
Status: TERMINATED
Conditions: Clear Cell Renal Cell Carcinoma|Recurrent Renal Cell Cancer|Stage IV Renal Cell Cancer
Interventions: DRUG: pazopanib hydrochloride|OTHER: laboratory biomarker analysis|PROCEDURE: dynamic contrast-enhanced magnetic resonance imaging|OTHER: pharmacogenomic studies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Vehicle Controlled Efficacy and Safety Study of Two Dose Regimens of CD07223 1.5% Topical Gel in Impetigo
Status: COMPLETED
Conditions: Impetigo
Interventions: DRUG: Experimental: CD07223 1.5 % Topical Gel BID|DRUG: Experimental: CD07223 1.5% Topical Gel TID|DRUG: Placebo Comparator: CD07223 vehicle gel BID|DRUG: Placebo Comparator: CD07223 vehicle gel TID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Inhaled Albuterol in Pulmonary Hypertension
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Albuterol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy Plus Durvalumab in Elderly Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: RADIATION: Radiotherapy|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accelerated Partial Breast Irradiation (APBI) Using Stereotactic Body Radiation Therapy (SBRT)
Status: RECRUITING
Conditions: Ductal Carcinoma in Situ|Invasive Ductal Carcinoma of Female Breast
Interventions: RADIATION: stereotactic body radiation therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Determine the Safety & Efficacy of ZPL-5212372 in Healthy Subjects and in Subjects With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: ZPL-5212372 1% w/w Ointment BID|DRUG: Placebo Ointment BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bryostatin 1 Plus Cisplatin in Treating Patients With Metastatic or Unresectable Cancer
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: bryostatin 1|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of H-1337 in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension
Status: ACTIVE_NOT_RECRUITING
Conditions: Glaucoma Open-Angle Primary|Ocular Hypertension
Interventions: DRUG: H-1337 0.6%|DRUG: H-1337 1.0%|DRUG: H-1337 Placebo|DRUG: Timolol 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Kidney and Bone Marrow Transplantation to Prevent Kidney Transplant Rejection
Status: COMPLETED
Conditions: Kidney Transplantation|Kidney Failure, Chronic
Interventions: PROCEDURE: Kidney Transplantation|PROCEDURE: Bone marrow transplantation|BIOLOGICAL: MEDI-507|DRUG: cyclophosphamide|BIOLOGICAL: rituximab|DRUG: Tacrolimus|DRUG: corticosteroids|RADIATION: thymic irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Pre-Surgery Exercise-Conditioning in Patients Waiting for Total Knee Arthroplasty (TKA)
Status: COMPLETED
Conditions: Osteo Arthritis Knee
Interventions: OTHER: P-SEC Pre-Surgical Care|OTHER: Normal pre-surgical care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Natural History of Medullary Thyroid Cancer to Inform Advanced Disease Management
Status: RECRUITING
Conditions: Advanced Thyroid Gland Medullary Carcinoma|Stage III Thyroid Gland Medullary Carcinoma AJCC v8|Stage IV Thyroid Gland Medullary Carcinoma AJCC v8|Stage IVA Thyroid Gland Medullary Carcinoma AJCC v8|Stage IVB Thyroid Gland Medullary Carcinoma AJCC v8|Stage IVC Thyroid Gland Medullary Carcinoma AJCC v8
Interventions: OTHER: Blood Pressure Measurement|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rescue Endovascular Therapy for Progressive Acute Mild Ischemic Stroke With Large Vascular Occlusion
Status: RECRUITING
Conditions: Stroke, Ischemic|Cerebrovascular; Disorder, Occlusive
Interventions: PROCEDURE: Endovascular therapy|DRUG: Best medical management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Dopamine Type 2 (D2) Receptor Occupancy Following a Single Oral Dose of OROS Paliperidone
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: OROS paliperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of BCD-020 in Therapy of Indolent Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Follicular Non-Hodgkin's Lymphoma|Nodal Marginal Zone Lymphoma|Splenic Marginal Zone Lymphoma
Interventions: BIOLOGICAL: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project PROTECT: Protecting Nursing Homes From Infections and Hospitalization
Status: COMPLETED
Conditions: Hospitalization|Infection
Interventions: DRUG: Chlorhexidine gluconate (CHG)|DRUG: Iodophor (10% povidone-iodine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Relationship of Muscular Agenesis: Thin Plantar and Palmar Long as a Biomarker of Injury and Performance Marker in the Lower Limb and Upper Limb Respectively
Status: NOT_YET_RECRUITING
Conditions: Abnormality, Congenital
Interventions: DIAGNOSTIC_TEST: Ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intrapartum Glucose Management Among Women With Gestational Diabetes Mellitus
Status: COMPLETED
Conditions: Gestational Diabetes Mellitus
Interventions: OTHER: Standard Protocol for intrapartum glucose management|OTHER: Experimental Protocol for intrapartum glucose management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase IV Trial to Determine the Safety and Immunogenicity of the WHO Formulation of the 2006-2007 Fluzone® Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza Virus Vaccine (2006-2007 Fluzone® vaccine)|BIOLOGICAL: Influenza Virus Vaccine (2006-2007 Fluzone® vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combined Digital Colposcopy Analysis to Improve Cervical Precancer and Cancer Detection
Status: COMPLETED
Conditions: Cervical Cancer|Precancerous Condition
Interventions: DEVICE: Multispectral Digital Colposcope (MDC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Contribution of 7 Tesla MRI of the Hypothalamus in the Diagnosis of Type 1 Narcolepsy
Status: RECRUITING
Conditions: Narcolepsy Type 1
Interventions: OTHER: 7T MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Abaloparatide and Pelvic Fracture Healing
Status: COMPLETED
Conditions: Fracture of Pelvis (Disorder)
Interventions: DRUG: Abaloparatide 80 micrograms per Pen dose|DRUG: Placebo prefilled injector pen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Efficacy of Paclitaxel and Olaparib in Comparison to Paclitaxel / Carboplatin Followed by Epirubicin/Cyclophosphamide as Neoadjuvant Chemotherapy in Patients With HER2-negative Early Breast Cancer and Homologous Recombination Deficiency
Status: COMPLETED
Conditions: Breast Cancer|Triple Negative Breast Neoplasms|HRpos Breast Neoplasms|BRCA 1 /2 and / or HRD
Interventions: DRUG: PwO|DRUG: PwCb|DRUG: EC|PROCEDURE: Surgery after neoadjuvant Therapy|OTHER: Stratification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Two Regiemns in Management of Sofosbuvir/Daclatasvir Failure
Status: COMPLETED
Conditions: HCV Coinfection
Interventions: DRUG: Sofosbuvir|DRUG: Simeprevir|DRUG: Daclatasvir|DRUG: Ribavirin|DRUG: Ombitasvir/paritaprevir/ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemorrhagic Brainstem Cavernous Malformations Treatment With Sirolimus: a Single Centre, Randomised, Placebo-controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Cavernous Malformations|Brain Stem Hemorrhage
Interventions: DRUG: Sirolimus|DRUG: Starch flake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Experience Success: Virtual Reality Skills Training to Enhance e-Weight Loss
Status: UNKNOWN
Conditions: Overweight|Obesity
Interventions: BEHAVIORAL: Weight Watchers Online|BEHAVIORAL: Experience Success Virtual Reality Platform
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CapsoCam® Colon Capsule Endoscope (CCE) Compared to Colonoscopy (OC)
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DEVICE: CapsoCam Colon Capsule Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Skeletal Muscle Dysfunction in Rheumatoid Arthritis (RA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Insulin Resistance
Interventions: DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of VTC-G15 (a Pentapeptide Cleavage Product og GLP-1) on Whole Body Glucose Metabolism in Man
Status: UNKNOWN
Conditions: Insulin Resistance
Interventions: DRUG: Last 5 amino acids of GLP-1|DRUG: placebo saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hepatobiliary Tumors Tissue Samples Acquisition
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Cholangiocarcinoma|Gallbladder Cancer|Biliary Tract Cancer|Liver Cancer|Precancerous Condition|Benign Hepatobiliary Disease|Healthy, no Evidence of Disease
Interventions: OTHER: Gene expression analysis|OTHER: Genomic analysis|OTHER: Protein expression analysis|OTHER: Proteomic profiling|OTHER: Polymerase chain reaction|OTHER: Mass spectrometry|OTHER: Immunohistochemistry|OTHER: Metabolomics profiling|OTHER: Methylation and epigenetic analysis|OTHER: Liquid biopsy analysis|OTHER: Laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Individualized Treatment Strategy for Patients With Metastatic Non-clear Cell Renal Cell Carcinoma
Status: UNKNOWN
Conditions: Metastatic Renal Cell Carcinoma|Kidney Neoplasm|Urologic Neoplasms|Urogenital Neoplasms
Interventions: DRUG: Medication (A specification is listed under each arm)|OTHER: Patient reported outcomes measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BCI-controlled NMES in Subacute Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: BCI-NMES|DEVICE: Sham-NMES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pterygium Head Body MMC1: Two Different Surgical Procedures and Their Effect on Endothelial Cell Count.
Status: UNKNOWN
Conditions: Pterygium
Interventions: DRUG: Mitomycin C 0.02%|PROCEDURE: Pterygium surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Endothelial Damage and Angiogenesis Biomarkers During COVID-19
Status: COMPLETED
Conditions: Covid19|Angiogenesis|Endothelial Dysfunction|Cardiovascular Morbidity
Interventions: DIAGNOSTIC_TEST: Endothelial damage and angiogenic biomarkers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Posterior Mandibular Ridge Augmentation Using Mineralized Plasmatic Matrix Versus Autogenous Bone Graft
Status: UNKNOWN
Conditions: Bone Augmentation
Interventions: PROCEDURE: Mineralized plasmatic matrix for bone augmentation|PROCEDURE: Autogenous bone for bone augmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Choosing the Right Pacing Mode in Heart Failure - The CHOICE Trial
Status: COMPLETED
Conditions: Heart Failure
Interventions: DEVICE: Bi Ventricular Pacing|DEVICE: Right Ventricular Pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of ONC1-0013B in Patients With Progressive Metastatic Castration-resistant Prostate Cancer
Status: COMPLETED
Conditions: Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Interventions: DRUG: ONC1-0013B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Modified Feeding Protocol on Neonatal Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Preterm|Birth Weight|Feeding Disorder Neonatal
Interventions: OTHER: Modified feeding Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Observational Cross-sectional Study Evaluating the Use of Re-sources and the Sociodemographic and Clinical Characteristics of Patients Diagnosed With Non-valvular Atrial Fibrillation With a Risk of Stroke or Systemic Embolism on Anticoagulant Therapy and Treated in Primary Care Centers
Status: COMPLETED
Conditions: Stroke|Prevention and Control|Atrial Fibrillation
Interventions: DRUG: Direct Oral Anticoagulant (DOAC)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Postprandial Response to Different Jams
Status: COMPLETED
Conditions: Postprandial|Hyperglycemia, Postprandial|Feeding Behaviors|Antioxidant|Lipid Profile
Interventions: OTHER: Strawberry Jam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Digital Capacitive Diathermy Versus Ultrasound on Myofascial Trigger Points
Status: COMPLETED
Conditions: Muscle Tonus
Interventions: DEVICE: Ultrasound Therapy|DEVICE: Digital Capacitive Diathermy Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peri-Implant Marginal Bone Loss And Implant Stability In Maxillary Implant Overdenture When Using Osseodensification Versus Conventional Drills: A Randomized Clinical Trial
Status: RECRUITING
Conditions: Completely Edentulous Maxilla|Implant Placement|Maxillary Implant Overdenture
Interventions: PROCEDURE: osteotomy for implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sorafenib in Treating Patients With Locally Advanced or Metastatic Kidney Cancer
Status: TERMINATED
Conditions: Hereditary Clear Cell Renal Cell Carcinoma|Kidney Cancer
Interventions: DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Surveillance Study to Monitor Natural Killer Cells and Circulating Tumor Cells in Women With Previously Treated Non-metastatic Triple Negative Breast Cancer and Women With Previously Treated Non-metastatic Breast Cancer With a Confirmed BRCA Mutation.
Status: UNKNOWN
Conditions: Triple Negative Breast Cancer|Natural Killer Cells|BRCA Mutation
Interventions: DEVICE: LiquidBiopsy®, NK VueTM
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exploratory Trial to Evaluate Premature Endothelial Dysfunction in Early Rheumatoid Arthritis(RA)Compared to Patients With Established RA, and Normal Subjects
Status: COMPLETED
Conditions: Premature Endothelial Dysfunction|Rheumatoid Arthritis|Healthy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy Study of Local Steroid Injection and Wrist Splinting for Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome|Local Steroid Injection|Wrist Splinting
Interventions: PROCEDURE: Local methylprednisolone acetate and lidnocaine injection|DEVICE: wrist splinting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stroke Recovery Initiative - Registry for Stroke Research Studies
Status: RECRUITING
Conditions: Stroke|Acute Stroke|Ischemic Stroke|Hemorrhagic Stroke|Subarachnoid Hemorrhage|Cerebral Ischemia|Cerebral Infarction|Cerebral Stroke|Cerebral Vascular Accident
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase II-b Randomized Clinical Trial of Cabazitaxel in Metastatic Colorectal Cancer Resistant to Standard Treatment
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: Cabazitaxel|OTHER: Best Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About the Study Medicine Called PF-07220060 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment
Status: RECRUITING
Conditions: Advanced or Metastatic Breast Cancer
Interventions: DRUG: PF-07220060 CDK4 inhibitor|DRUG: Fulvestrant|DRUG: Everolimus|DRUG: Exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Facilitation of Zolpidem (≥10 mg) Discontinuation Through Use of Ramelteon in Subjects With Chronic Insomnia
Status: COMPLETED
Conditions: Chronic Insomnia
Interventions: DRUG: Ramelteon and zolpidem|DRUG: Placebo and zolpidem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Peking University Birth Cohort in Weifang (PKUBC-WF)
Status: NOT_YET_RECRUITING
Conditions: Health Problems in Pregnancy|Pregnancy Outcomes|Gestational Diabetes|Gestational Hypertension|Preterm Birth|Obesity|Mother-Infant Interaction|Child Development|Anemia
Interventions: OTHER: No Interventions
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Prescriptive Validity of a Novel Fall Risk Clinical Prediction Rule for People With COPD
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: Balance Training|OTHER: Breathing and Stretching Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Minimum Effective Volume of Local Anesthetic Using Ultrasound for Brachial Plexus Block
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: bupivacaine 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect on QTcF of Baxdrostat Compared With Placebo, Using Moxifloxacin as a Positive Control, in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Baxdrostat|DRUG: Placebo|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Covid-19 Vaccination in Eswatini Against SARS-CoV-2 Associated Hospitalization and Death
Status: COMPLETED
Conditions: COVID-19|Pneumonia, Viral
Interventions: BIOLOGICAL: AZD1222
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION