pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of MLN0264 in Participants With Cancer of the Stomach or Gastroesophageal Junction
Status: TERMINATED
Conditions: Adenocarcinoma of the Stomach|Gastroesophageal Junction Expressing Guanylyl Cyclase C
Interventions: DRUG: MLN0264
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Double Faced Transverse Preputial Onlay Island Flap for Hypospadias Repair in Pediatrics
Status: COMPLETED
Conditions: Hypospadias
Interventions: PROCEDURE: Double faced transverse preputial onlay island flap|PROCEDURE: Transverse inner preputial onlay island flap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects and Safety of Sacubitril/Valsartan on Refractory Hypertension
Status: UNKNOWN
Conditions: Resistant Hypertension
Interventions: DRUG: Sacubitril/valsartan|DRUG: valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PROTECT I, A Prospective Feasibility Trial Investigating the Use of IMPELLA RECOVER LP 2.5 System in Patients Undergoing High Risk PCI
Status: COMPLETED
Conditions: Patients Undergoing High Risk PCI.
Interventions: DEVICE: High Risk PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VELCADE,Rituximab,Cyclophosphamide and Decadron
Status: TERMINATED
Conditions: Lymphoma, Non-Hodgkin|Lymphoma, B-Cell
Interventions: DRUG: VELCADE®|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Decadron
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Immediate Post-injury Fluoxetine Improve the Recovery Trajectories of Victims in Bodily Trauma?
Status: RECRUITING
Conditions: Musculoskeletal Injury
Interventions: DRUG: Fluoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Local Anesthetics for Pain Reduction Prior to IV Line Placement
Status: COMPLETED
Conditions: Pain|Local Anesthesia for Peripheral Intravenous Catheterization
Interventions: DRUG: Lidocaine|DRUG: Buffered Lidocaine|DRUG: Bacteriostatic Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Pain Management After Elective Shoulder Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Hydromorphone Hcl 4Mg Tab|DRUG: Piritramide 15mg s.c.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Accelerated Recovery After MIS Hepatectomy (ARAMIS Hep) to Support Early Discharge for Patients Undergoing Minimally Invasive Liver Resection
Status: RECRUITING
Conditions: Liver
Interventions: BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: EVARREST™ Fibrin Sealant Patch Post-Market Study
Status: COMPLETED
Conditions: Hemorrhage|Soft Tissue Bleeding
Interventions: BIOLOGICAL: EVARREST™ Fibrin Sealant Patch|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Perioperative Intravenous Lidocaine Infusion and Magnesium Infusion on the Functional Recovery After General Anesthesia in the Patients Undergoing Breast Mastectomy
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Lidocaine|DRUG: Magnesium Sulfate|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: To Study the Effect of Early Cooling in Acute Subdural Hematoma Patients
Status: TERMINATED
Conditions: Subdural Hematoma, Traumatic
Interventions: DEVICE: Temperature management Zoll Intravascular Temperature Management device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care (SOC) Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Neoplasms|Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma
Interventions: DRUG: Niraparib|DRUG: Dostarlimab (TSR-042)|DRUG: Standard of care|DRUG: Dostarlimab-Placebo|DRUG: Niraparib-Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sintilimab (IBI308) in Combination With Chidamide and Azacitidine in Refractory or Relapsed PTCL
Status: NOT_YET_RECRUITING
Conditions: Peripheral T-cell Lymphoma
Interventions: DRUG: Sintilimab|DRUG: Chidamide|DRUG: Azacidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma.
Status: COMPLETED
Conditions: Bone Metastases
Interventions: BIOLOGICAL: Denosumab|DRUG: Zoledronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Botulinum Toxin Type A for Injection (HengLi®) in the Treatment of Trigeminal Neuralgia
Status: ENROLLING_BY_INVITATION
Conditions: Trigeminal Neuralgia
Interventions: DRUG: Botulinum Toxin Type A for Injection,also known as "HengLi®"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase IIb Study to Investigate the Efficacy and Tolerability of Lower Doses Cinaciguat (25 µg/h, 10 µg/h) Given Intravenously to Patients With Acute Decompensated Chronic Congestive Heart Failure (ADHF)
Status: TERMINATED
Conditions: Acute Heart Failure
Interventions: DRUG: Cinaciguat (BAY58-2667)|DRUG: Cinaciguat (BAY58-2667)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Subjects With Advanced or Metastatic Solid Tumor Malignancies
Status: NOT_YET_RECRUITING
Conditions: Metastatic Solid Tumor|Advanced Solid Tumor
Interventions: DRUG: XT-0528
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerance of Chlorhexidine Gluconate Vaginal Cleansing Solution
Status: COMPLETED
Conditions: Surgical Preparation of the Vagina
Interventions: DRUG: Povidone-Iodine|DRUG: 4% Chlorhexidine Gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effect of Liners on Pulpal Outcome and Restoration Survival After Partial Caries Excavation
Status: COMPLETED
Conditions: Reversible Pulpitis
Interventions: PROCEDURE: PCR with calcium hydroxide|PROCEDURE: PCR with RMGIC|PROCEDURE: PCR with direct composite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Treatment Effects Using Cultured, Allogeneic Mesenchymal Stromal Stem Cells (MSCs) in Knee Osteoarthritis
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: BIOLOGICAL: Knee aspiration + UCB-MSCs|OTHER: Knee aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Radial Extracorporeal Shockwave Therapy on Tennis Elbow
Status: COMPLETED
Conditions: Lateral Epicondylosis|Lateral Epicondylitis|Tennis Elbow
Interventions: PROCEDURE: Radial extracorporeal shock wave therapy (rESWT)|PROCEDURE: sham shockwave therapy|PROCEDURE: Physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Omega 3 Fatty Acids and ERPR(-)HER2(+/-) Breast Cancer Prevention
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DIETARY_SUPPLEMENT: omega 3 fatty acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Maintenance of Response After rTMS for Depression Using tDCS
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: active tDCS + mindfulness meditation|OTHER: sham tDCS + mindfulness meditation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Therapeutic Iobenguane (131-I) and Vorinostat for Recurrent or Progressive High-Risk Neuroblastoma Subjects
Status: RECRUITING
Conditions: Neuroblastoma|Neuroectodermal Tumors|Neoplasms
Interventions: DRUG: 131I-MIBG|DRUG: 131-MIBG + Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Exenatide on Post-Meal Sugar Peaks and Vascular Health in Obese/Pre-Diabetic Young Adults
Status: WITHDRAWN
Conditions: Obesity|Insulin Resistance|Impaired Glucose Tolerance|Cardiovascular Disease
Interventions: DRUG: Exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does a GLP-1 Receptor Agonist Change Glucose Tolerance in Antipsychotic-treated Patients?
Status: UNKNOWN
Conditions: Impaired Glucose Tolerance Associated With Drugs
Interventions: DRUG: Liraglutide|DRUG: Liraglutide Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Adult and Adolescent Participants With Atypical Hemolytic Uremic Syndrome (aHUS)
Status: RECRUITING
Conditions: Atypical Hemolytic Uremic Syndrome
Interventions: DRUG: Crovalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Traditional Asian Diet on Gut Microbiome and Metabolome in Healthy Volunteers and Pregnancy on Subsequent Infant's Allergy Development
Status: ENROLLING_BY_INVITATION
Conditions: Pregnancy|Food Hypersensitivity|Healthy
Interventions: BEHAVIORAL: Traditional Asian Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Adhesive Performance of Glass Ionomer and Resin Based Adhesive Systems: A 3 Years Prospective Clinical Evaluation
Status: COMPLETED
Conditions: Dental Leakage
Interventions: PROCEDURE: Etching with phosphoric acid gel (3M ESPE, St. Paul, MN, USA)|PROCEDURE: Self-etch adhesive (Kuraray, Tokyo, Japan)|PROCEDURE: Chemical bond adhesive (GC, Corporation, Tokyo, Japan)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Participants With Moderate to Severe Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Baricitinib|DRUG: Methotrexate|DRUG: Baricitinib Placebo|DRUG: MTX Placebo|DRUG: Folic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study of Gabapentin Tablets 800 mg Under Non-fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Gabapentin 800 mg Tablets, single dose|DRUG: NEURONTIN® 800 mg Tablets, single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Joyuus - A Web-based Tool for Postpartum Care Self-care for Underserved Women
Status: RECRUITING
Conditions: Maternal Health
Interventions: OTHER: Joyuus Self-care Mobile App|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Estimation of Benefit From Regular Versus Leakage-related Exchange of Voice Prosthesis in Patients Post Laryngectomy.
Status: UNKNOWN
Conditions: Laryngectomy|Voice|Prosthesis Failure
Interventions: DEVICE: Provox prosthesis exchange
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Targeted Lung Denervation for Patients With Moderate to Severe COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DEVICE: Holaira™ Lung Denervation System with energy delivery|DEVICE: Holaira™ Lung Denervation System without energy delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Subarachnoid-Subarachnoid (S-S) Bypass Versus Adhesion Lysis in Spinal Arachnoiditis and Syringomyelia
Status: RECRUITING
Conditions: Syringomyelia
Interventions: PROCEDURE: Subarachnoid-Subarachnoid (S-S) Bypass|PROCEDURE: Intradural Adhesion Lysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficiency of HHHFNC Between Unheated Oxygen Therapy in Difficult Weaning Patients After Extubation in RCC
Status: COMPLETED
Conditions: Critically Illness
Interventions: DEVICE: Heated Humidified High-Flow Nasal Cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Methods to Manage Intra-operative Floppy-iris Syndrome and Poor Pupil Dilation in Cataract Surgery
Status: UNKNOWN
Conditions: Management of Intraoperative Floppy-iris Syndrome and Small Pupils With Different Mechanical Devices
Interventions: DEVICE: Malyugin Ring|DEVICE: Iris hooks|DEVICE: standard OVD|DEVICE: OVD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Celecoxib and Erlotinib in Treating Former Smokers With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Recurrent Non-small Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: DRUG: erlotinib hydrochloride|DRUG: celecoxib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Buprenorphine Sublingual Spray Versus Standard of Care Narcotic Therapy for the Treatment of Post-Operative Pain
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Buprenorphine Sublingual Spray|DRUG: Morphine|DRUG: Oxycodone Hydrochloride|DRUG: Zofran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Relative Bioavailability of BMS-626529 Administered as BMS-663068 From 150mg Low-dose Extended-release Tablets Compared to 600mg Reference Extended-release Tablets in Healthy Subjects
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: BMS-663068 (1 tablet at 600 mg)|DRUG: BMS-663068 (4 tablets at 150 mg each tablet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Ifetroban in Patients With Idiopathic Pulmonary Fibrosis (IPF)
Status: RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Ifetroban Sodium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perturbation Training Compared to Balance and Strengthening Exercise, for Elderly at Risk of Falling
Status: UNKNOWN
Conditions: Fall Prevention
Interventions: DEVICE: Balance Tutor Biofeedback Rehabilitation System|OTHER: Balance and strengthening exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Bipolar Radiofrequency Probe (ENDOHPB) in the Management of Unresectable Bile Duct and Pancreatic Cancer
Status: TERMINATED
Conditions: Cholangiocarcinoma|Pancreatic Cancer
Interventions: DEVICE: Endoscopic bipolar radiofrequency probe (ENDOHPB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualised Versus Standard Care for Breast Cancer Patients at High-risk for Chemotherapy-induced Nausea and Vomiting The ILIAD Study
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Olanzapine|DRUG: Olanzapine Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Averting NAS Among Opioid-Using Young Women Receiving MAT Using Buprenorphine
Status: UNKNOWN
Conditions: Opioid-use Disorder|Contraception|Neonatal Abstinence Syndrome
Interventions: BEHAVIORAL: Motivational Interviewing and Educational Training (MIET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Mechanisms of Diuretic Resistance in Heart Failure, Aim 3
Status: NOT_YET_RECRUITING
Conditions: Heart Failure|Diuretic Resistance
Interventions: DRUG: Ammonium Chloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Fiber Snack Foods on Dietary Intake in Healthy Adults
Status: COMPLETED
Conditions: Fructooligosaccharide
Interventions: DIETARY_SUPPLEMENT: Control study food with no added fiber|DIETARY_SUPPLEMENT: Study food with added fiber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Phase II, Randomized, Double-blind, Placebo-controlled, in Parallel Groups Clinical Trial to Assess the Safety and Efficacy of Dietary Supplementation With Tryptophan to Achieve Weight Loss, and Its Neuropsychological Effects in Adolescents With Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: TRYPTOPHAN|OTHER: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Angioplasty Guidewire-Assisted Versus Conventional Transseptal Puncture for Left Atrial Appendage Occlusion
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: angioplasty guidewire-assisted transseptal puncture or Standard conventional transseptal puncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Tolerability & PK of rhNGF in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: rhNGF 20μg/mL|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of Multiple Rising Oral Doses of BI 44370 TA Tablets in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 44370 TA|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Research Study to Compare a New Medicine "Fast-acting Insulin Aspart" to Another Medicine "Insulin Aspart" in Chinese People With Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DRUG: Faster aspart|DRUG: Insulin aspart|DRUG: Insulin degludec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Perioperative Effects of Dexmedetomidine and Ketamine Sedation in Septorhinoplasty Operations
Status: COMPLETED
Conditions: Anesthesia|Intravenous Anesthetic Toxicity
Interventions: DRUG: Dexmedetomidine|DRUG: Ketamine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Home Exercise vs PT for Reverse Total Shoulder Arthroplasty
Status: ACTIVE_NOT_RECRUITING
Conditions: Shoulder Arthritis|Rotator Cuff Tear Arthropathy
Interventions: OTHER: Physical Therapy|OTHER: Home Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Effectiveness and the Safety of a Medical Device in the Treatment of Common Warts and Plantar Warts.
Status: RECRUITING
Conditions: Warts|Plantar Wart|Common Wart
Interventions: DEVICE: Sérum VERRUPRO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TD-4208 Absorption, Distribution, Metabolism and Excretion (ADME) Study in Healthy Male Subjects
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: TD-4208
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Global Smart Drinking Goals Initiative
Status: UNKNOWN
Conditions: Binge Drinking, Underage Drinking, Drinking and Driving, Alcohol-Related Harms
Interventions: BEHAVIORAL: GSDG multi-component intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Chloroprocaine vs Lidocaine for Epidural Anesthesia in Cesarean Delivery
Status: COMPLETED
Conditions: Surgical Anesthesia, Cesarean Section
Interventions: DRUG: 2% Lidocaine|DRUG: 3% Chloroprocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Ablation Combined With Recombinant Human Adenovirus Type 5 in the Treatment of Hepatocellular Carcinoma.
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: H101|PROCEDURE: RFA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Time-lapse Morphological Kinetics in the Selection of Blastocysts
Status: COMPLETED
Conditions: Viability
Interventions: DEVICE: Embryoscope|OTHER: Conventional Criteria
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Homoharringtonine With Oral Gleevec in Chronic, Accelerated and Blast Phase Chronic Myeloid Leukemia (CML)
Status: TERMINATED
Conditions: Myeloid Leukemia, Chronic|Myeloid Leukemia, Chronic, Accelerated-Phase|Blast Phase|Myeloid Leukemia, Chronic, Chronic-Phase
Interventions: DRUG: Homoharringtonine|DRUG: Imatinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closed Loop Acoustic Stimulation During Sedation With Dexmedetomidine
Status: ACTIVE_NOT_RECRUITING
Conditions: Sleep|Sedation Complication
Interventions: RADIATION: MRI|DIAGNOSTIC_TEST: Quantitative Sensory Testing (QST)|DIAGNOSTIC_TEST: Home sleep study|OTHER: Acoustic stimulation (65db) up-slope of EEG with QST|OTHER: Acoustic stimulation (65db) down-slope of EEG with QST|OTHER: 0 db with QST|DRUG: Dexmedetomidine|OTHER: Breathe-Squeeze Task
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Incidence of Bleeding on Probing as an Indicator of Peri-Implant Disease Progression
Status: ENROLLING_BY_INVITATION
Conditions: Peri-Implantitis|Bleeding of Subgingival Space
Interventions: DIAGNOSTIC_TEST: Clinical measurements|DIAGNOSTIC_TEST: Radiographic measurement|PROCEDURE: Dental prophylaxis or maintenance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Evaluating Safety Of BMP-655/ACS As An Adjuvant Therapy For Rotator Cuff Repair
Status: TERMINATED
Conditions: Rotator Cuff Tear
Interventions: BIOLOGICAL: BMP-655/ACS or Standard of Care|BIOLOGICAL: BMP-655/ACS or Standard of Care|BIOLOGICAL: BMP-655/ACS or Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Different Relaxation Techniques on Psoriasis Patients With an Elevated Psychological Stress Level
Status: RECRUITING
Conditions: Psoriasis|Stress, Psychological|Depression|Anxiety
Interventions: BEHAVIORAL: Psychological stress relief techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma
Status: UNKNOWN
Conditions: Allergic Asthma|Airway Remodelling|Extracellular Matrix Alteration
Interventions: PROCEDURE: Bronchial challenge with allergen|OTHER: Co-culture formation|OTHER: Inhibition of Wnt and Smad signaling pathways|OTHER: Extracellular matrix turnover and deposition assessment|BIOLOGICAL: Dermatophagoides pteronyssinus allergen|DEVICE: Dosimeter ProvoX (Ganshorn)|BIOLOGICAL: Eosinophils|BIOLOGICAL: Airway smooth muscle cells|BIOLOGICAL: Fibroblasts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of DNHS Technique in the Treatment of Upper Limb Spasticity and Function in Stroke
Status: COMPLETED
Conditions: Stroke|Spasticity
Interventions: DEVICE: DNHS ® (Dry Needling for Hypertonia and Spasticity)|DEVICE: Sham Dry Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate Safety and Tolerability of ALN-PCS02 in Subjects With Elevated LDL-Cholesterol (LDL-C)
Status: COMPLETED
Conditions: Elevated LDL-Cholesterol (LDL-C)
Interventions: DRUG: ALN-PCS02|DRUG: Sterile Normal Saline (0.9% NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Revascularization With Open Bypass Versus Angioplasty and STenting of the Lower Extremity Trial (ROBUST)
Status: COMPLETED
Conditions: Superficial Femoral Artery Stenosis|Superficial Femoral Artery Occlusion|Claudication|Rest Pain
Interventions: PROCEDURE: Open Bypass Surgery|PROCEDURE: Angioplasty and Stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Management of Multiple Mucoepidermoid Carcinoma and Adenocarcinoma
Status: COMPLETED
Conditions: Adenocarcinoma; Mucoepidermoid Carcinoma
Interventions: PROCEDURE: resection of mucoeidermoid carcinoma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Recurrent Brain Tumors: Metabolic Manipulation Combined With Radiotherapy
Status: UNKNOWN
Conditions: Brain Neoplasms
Interventions: RADIATION: Partial brain re-irradiation.|DRUG: Metformin|BEHAVIORAL: low carbohydrate diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Local Intramuscular Injection for Treatment of Uterine Scars
Status: WITHDRAWN
Conditions: Uterine Scar
Interventions: OTHER: Umbilical cord MSCs|OTHER: 0.9% Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, PK and Effectiveness of IV Peramivir Versus Oseltamivir in Pediatric Subjects With Uncomplicated Influenza
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: Peramivir|DRUG: Oseltamivir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Interleukin-6 Receptor Antagonist Tocilizumab in Patients With Hand Osteoarthritis
Status: COMPLETED
Conditions: Hand Osteoarthritis
Interventions: DRUG: tocilizumab|DRUG: saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vinorelbine in Relapsed Platinum Resistant or Refractory C5 High Grade Serous, Endometrioid, or Undifferentiated Primary Peritoneum, Fallopian Tube or Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer|Fallopian Tube Cancer
Interventions: DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Effect of Dulaglutide With Liraglutide in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: LY2189265|DRUG: Liraglutide|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Blood Flow Restrıcted Resistive And Aerobic Exercises in Chronic Obstructive Pulmonary Patients
Status: ENROLLING_BY_INVITATION
Conditions: Copd
Interventions: PROCEDURE: Blood flow restricted and normal aerobic exercise and resistance exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Gut Hormones on Food Intake After Roux-en-Y Gastric Bypass Surgery
Status: COMPLETED
Conditions: Severe Obesity
Interventions: DRUG: exendin 9-39|DRUG: sitagliptin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of Monoclonal Antibodies for the Treatment of Mild to Moderate COVID-19 in Non-Hospitalized Setting
Status: UNKNOWN
Conditions: Covid19
Interventions: BIOLOGICAL: BAMLANIVIMAB|BIOLOGICAL: CASIRIVIMAB|BIOLOGICAL: IMDEVIMAB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of Menactra® Vaccine in Subjects Aged 9 to 23 Months in India and in the Russian Federation
Status: COMPLETED
Conditions: Meningitis|Meningococcal Infection
Interventions: BIOLOGICAL: Meningococcal Diphtheria Toxoid Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Safety and Efficacy of Ibrutinib in Refractory/Relapsed Autoimmune Hemolytic Anemia
Status: RECRUITING
Conditions: Refractory/Relapsed Autoimmune Hemolytic Anemia
Interventions: DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhanced Stress Resilience Training for Residents
Status: COMPLETED
Conditions: Stress|Mindfulness|Cognitive Change
Interventions: BEHAVIORAL: Enhanced Stress Resilience Training (ESRT)|BEHAVIORAL: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of a Homeopathic Anti-inflammatory Topical Cream on Ulcers and Neuropathy in the Diabetic Foot
Status: UNKNOWN
Conditions: Diabetic Neuropathy
Interventions: OTHER: Neuropathy/Ulcer Homeopathic topical cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiolabelled CCK-2/Gastrin Receptor Analogue for Personalized Theranostic Strategy in Advanced MTC
Status: COMPLETED
Conditions: Medullary Thyroid Carcinoma
Interventions: DRUG: 111In-CP04|DRUG: 111In-CP04 with co-administration of gelofusine/gelaspan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Anidulafungin During Continuous Venovenous Hemofiltration (CVVHF)
Status: UNKNOWN
Conditions: Acute Renal Failure|Infection
Interventions: DRUG: Anidulafungin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prediction of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma Based on Ultrasound and Cytological Images
Status: COMPLETED
Conditions: Papillary Thyroid Carcinoma|Lymph Node Metastasis
Interventions: PROCEDURE: Thyroidectomy and lymph node dissection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Exercise Intervention to Reduce Neuropathic Pain and Brain Inflammation After Spinal Cord Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Cord Injuries
Interventions: OTHER: Functional Electrical Stimulation rowing exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Which is Better Piezosurgery or LLLT in Accelerating Orthodontic Tooth Movement
Status: COMPLETED
Conditions: Class II Malocclusion
Interventions: PROCEDURE: Piezocision|DEVICE: Low-level laser|DEVICE: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Posaconazole Prophylaxis During ATG Treatment for hMDS/AA Patients
Status: COMPLETED
Conditions: Aplastic Anemia|Myelodysplastic Syndromes|Fungal Infection
Interventions: DRUG: Posaconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma Multiforme|Anaplastic Astrocytoma|Anaplastic Oligodendroglioma|DIPG|High-grade Astrocytoma NOS|CNS Primary Tumor, NOS (Malignant Glioma)
Interventions: DRUG: INCB7839
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1a Study Evaluating the Safety, Tolerability, and Efficacy of IBI322 in Subjects With Advanced Cancers
Status: COMPLETED
Conditions: Advanced Malignant Tumors Lymphomas
Interventions: BIOLOGICAL: IBI322 Recombinant anti-human CD47/PD-L1 bispecific antibody injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intranasal Bevacizumab for HHT-Related Epistaxis
Status: COMPLETED
Conditions: HHT|Hereditary Hemorrhagic Telangiectasia|Epistaxis|Nose Bleeds|Nasal Bleeding
Interventions: DRUG: Bevacizumab|DRUG: Placebo (Saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Postural Re-education Intervention Compared to Standard Care on Scoliosis Progression in Adolescent
Status: RECRUITING
Conditions: Adolescent Idiopathic Scoliosis
Interventions: OTHER: Global postural re-education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Crossover Study to Determine the Effect on Lung Function of Indacaterol in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD), Using Tiotropium as an Active Control
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Indacaterol|DRUG: Tiotropium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DuRvalumab With chEmotherapy as First Line treAtment in Advanced Pleural Mesothelioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Mesothelioma|Pleural Mesothelioma|Malignant Pleural Mesothelioma
Interventions: DRUG: Durvalumab|DRUG: Standard Chemotherapy|DRUG: Ipilimumab and Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Telmisartan With ART During Acute HIV Infection to Reduce the CNS Reservoirs of HIV and Lymph Node Fibrosis
Status: COMPLETED
Conditions: Acute HIV Infection|HIV CNS Involvement
Interventions: DRUG: TDF/3TC/EFV + Telmisartan|DRUG: TDF/3TC/EFV only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Bioavailability, Food Effect and Pharmacokinetics of Deuremidevir Hydrobromide for Suspension
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Deuremidevir Hydrobromide for Suspension 100mg|DRUG: Deuremidevir Hydrobromide for Suspension 300mg|DRUG: Deuremidevir Hydrobromide for Suspension 25mg|DRUG: Deuremidevir Hydrobromide tablets 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Follow-up Study to Evaluate Durability of Sustained Virologic Response (SVR) in Previous GSK3228836 Study Participants (B-Sure)
Status: RECRUITING
Conditions: Hepatitis B
Interventions: DRUG: GSK3228836
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of the Safety and Efficacy of MK-0773 in Women With Sarcopenia (Loss of Muscle Mass)(MK-0773-005)
Status: COMPLETED
Conditions: Sarcopenia
Interventions: DRUG: Comparator: MK-0773|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study : to Evaluate the Panty MOBIDERM in Patients With Pelvic and/or Genital Lymphedema
Status: COMPLETED
Conditions: Lymphedema of Genitalia
Interventions: DEVICE: MOBIDERM Panty group
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pericapsular Nerve Group Block in Hip Arthroplasty
Status: COMPLETED
Conditions: Post Operative Pain After Hip Arthroplasty
Interventions: PROCEDURE: pericapsular nerve group block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of LY2623091 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: LY2623091|DRUG: Itraconazole|DRUG: Simvastatin|DRUG: Tadalafil|DRUG: Diltiazem
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Melatonin Treatment and Inflammation, Oxidative Stress and Autonomic Function in Connection With Surgery
Status: UNKNOWN
Conditions: Oxidative Stress|Inflammatory Stress|Myocardial Ischaemia
Interventions: DRUG: Melatonin (drug)|DRUG: Laktose
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vagus Nerve Stimulation to Treat Moderate Traumatic Brain Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury|Acute Brain Injuries
Interventions: DEVICE: gammaCore active device|DEVICE: gammaCore sham device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Decision Making On Location of Care With the Frail Elderly and Their Caregivers
Status: COMPLETED
Conditions: Decision Process About the Location of Care Among Frail Elderly
Interventions: BEHAVIORAL: Training|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Early Effects of a New Oral Nicotine Replacement Product and NiQuitin™ Lozenge
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Nicotine|DRUG: Nicotine|DRUG: Nicotine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Logotherapy Counseling Programme for Palliative Care Patients With Chronic Sorrow
Status: RECRUITING
Conditions: Palliative Care|Cancer
Interventions: OTHER: Logotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Drug - Drug Interaction Study Between Quinine Sulfate and Theophylline
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Theophylline 300mg|DRUG: Quinine 648 mg|DRUG: Theophylline 300 mg|DRUG: Quinine 648 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Oral Lixivaptan Capsules in Subject With Euvolemic Hyponatremia
Status: COMPLETED
Conditions: Hyponatremia With Normal Extracellular Fluid Volume
Interventions: DRUG: lixivaptan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamics (PD) and Pharmacokinetics (PK) Study of EP-100 in Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors|Advanced Solid Tumors
Interventions: DRUG: EP-100
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Innovative Conversational Agent (Quitbot) for Smoking Cessation
Status: ACTIVE_NOT_RECRUITING
Conditions: Cigarette Smoking-Related Carcinoma
Interventions: OTHER: Experimental Smoking Cessation Program|OTHER: Control Smoking Cessation Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PET/MRI Study on the Neurological Mechanism of rTMS Treatment for Heroin Addiction
Status: UNKNOWN
Conditions: Heroin Addiction|Relapse
Interventions: DEVICE: Repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder
Status: RECRUITING
Conditions: Major Depressive Disorder|Alcohol Use Disorder
Interventions: DRUG: Psilocybin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Intracranial Self-expanding DES in Symptomatic Intracranial Atherosclerotic Disease
Status: COMPLETED
Conditions: Intracranial Arterial Diseases|Stent Restenosis|Percutaneous Transluminal Angioplasty
Interventions: DEVICE: Self-expanding intracranial drug stent system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: YM598 Added to Mitoxantrone/Prednisone to Control Pain in Metastatic Prostate Cancer Patients No Longer Responding to Hormone Therapy
Status: TERMINATED
Conditions: Hormone-Refractory Prostate Cancer|Prostatic Neoplasms
Interventions: DRUG: YM598
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT