pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Platelet-rich Plasma in Treating Patients With Tibiofemoral Cartilage Degeneration
Status: COMPLETED
Conditions: Cartilage Degeneration
Interventions: BIOLOGICAL: platelet rich plasma injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endothelial Facilitation in Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Simvastatin|DRUG: L-Arginine|DRUG: Tetrahydrobiopterin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Connective Tissue Graft Wall Technique in Management of Cairo's RT2 and RT3 With Intra-bony Defects
Status: COMPLETED
Conditions: Recession, Gingival
Interventions: PROCEDURE: De-epithelialized connective tissue graft wall
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7079901 and the Combination of RO7079901 With Meropenem in Adult Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: RO7079901|DRUG: Meropenem|OTHER: RO7049389 Placebo|OTHER: Meropenem Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Retina Microvascular Remodeling and Cognitive Function In Hypertension
Status: UNKNOWN
Conditions: Hypertension|Mild Cognitive Impairment
Interventions: BEHAVIORAL: Cognitive tests|BIOLOGICAL: Blood test|RADIATION: Brain and aorta RMI|OTHER: Adaptative optics
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cognitive-Behavioral Therapy Enriched With Emotion Regulation Training for Multiple Somatoform Symptoms
Status: COMPLETED
Conditions: Somatic Symptom Disorder (DSM-V)
Interventions: BEHAVIORAL: Cognitive-behavioral therapy + emotion regulation training for patients with multiple somatoform symptoms|BEHAVIORAL: Cognitive-behavioral therapy for patients with multiple somatoform symptoms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Two-part Safety, Tolerability, Pharmacodynamic and -Kinetic Study of Inhaled AZD8871 in Asthmatic and COPD Subjects
Status: COMPLETED
Conditions: Asthma (Part 1)|COPD (Part 2)
Interventions: DRUG: Dose 1, AZD8871 50 μg (Part 1)|DRUG: Dose 2, AZD8871 100 μg (Part 1)|DRUG: Dose 3, AZD8871 300 μg (Part 1)|DRUG: Dose 4, AZD8871 600 µg (Part 1)|DRUG: Dose 5, AZD8871 1200 µg (Part 1)|DRUG: Dose 6, AZD8871 1800 μg (Part 1)|DRUG: Placebo, AZD8871 placebo (Part 1)|DRUG: Treatment A, AZD8871 dose A (Part 2)|DRUG: Treatment B, AZD8871 dose B (Part 2)|DRUG: Treatment C, Indacaterol 150 μg (Part 2)|DRUG: Treatment D, Tiotropium 18 μg (Part 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab and Ipilimumab After Donor Stem Cell Transplant in Treating Patients With High Risk Refractory or Relapsed Acute Myeloid Leukemia or Myelodysplastic Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Allogeneic Hematopoietic Stem Cell Transplantation Recipient|Myelodysplastic Syndrome|Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Staging and Dose Escalated Radiotherapy of Prostate Carcinoma With PET and MRI
Status: COMPLETED
Conditions: Prostate Carcinoma
Interventions: DEVICE: PET/CT, PET/MRI, mpMRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Conventional and Long Pulse Widths During a Temporary Spinal Cord Stimulation Trial
Status: COMPLETED
Conditions: Spinal Cord Stimulation|Pain, Back|Pain
Interventions: DEVICE: Algovita Spinal Cord Stimulation System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients Patients
Status: RECRUITING
Conditions: Cognitive Decline|Dementia, Vascular|Alzheimer Disease|Dementia|Stroke
Interventions: OTHER: Behavioral Dietary intervention ( MIND Diet)|OTHER: Behavioral Usual Care Diet Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PENS or TENS for Pain in Pancreatic Cancer
Status: COMPLETED
Conditions: Pain|Cancer Pain|Pancreatic Cancer
Interventions: DEVICE: PENS|DEVICE: TENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of TLL018 in Patients With Chronic Spontaneous Urticaria.
Status: COMPLETED
Conditions: Chronic Spontaneous Urticaria
Interventions: DRUG: TLL018 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Trial to Evaluate Intravesical Nadofaragene Firadenovec Alone or in Combination With Chemotherapy or Immunotherapy in Participants With High-grade BCG Unresponsive Non-muscle Invasive Bladder Cancer
Status: NOT_YET_RECRUITING
Conditions: Non-muscle Invasive Bladder Cancer With Carcinoma in Situ
Interventions: DRUG: Nadofaragene Firadenovec|DRUG: Gemcitabine|DRUG: Docetaxel|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-calorie Diet in Isolated Impaired Fasting Glucose
Status: NOT_YET_RECRUITING
Conditions: Isolated Impaired Fasting Glucose
Interventions: BEHAVIORAL: Low-calorie diet|BEHAVIORAL: Routine dietary and physical activity habits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cisplatin, Docetaxel, and Pembrolizumab in Treating Patients With Stage II-III Laryngeal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Laryngeal Squamous Cell Carcinoma|Stage II Laryngeal Cancer AJCC v8|Stage III Laryngeal Cancer AJCC v8
Interventions: DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Docetaxel|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy
Status: TERMINATED
Conditions: Symptomatic Neurogenic Orthostatic Hypotension|Parkinson's Disease|Multiple Systems Atrophy|Pure Autonomic Failure|Dopamine Beta Hydroxylase Deficiency
Interventions: DRUG: Droxidopa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Leveraging Telehealth to Improve Oral Health Among Cancer Survivors
Status: NOT_YET_RECRUITING
Conditions: Oral Mucositis|Periodontal Diseases|Cancer
Interventions: BEHAVIORAL: Telehealth Intervention (THI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Individualized Theta-tACS on a Working Memory Training at SCD
Status: NOT_YET_RECRUITING
Conditions: Subjective Cognitive Decline
Interventions: DEVICE: transcranial alternating current stimulation (tACS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long-Term Treatment and Follow up of Subjects Completing 24 Months of Treatment With Tesevatinib on Study KD019-101
Status: TERMINATED
Conditions: Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Interventions: DRUG: tesevatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Characterization of CTCs and ctDNA in Blood and Plasma Samples From Patients With Metastatic and/or Hormone-Resistant Prostate Cancer
Status: TERMINATED
Conditions: Hormone-Resistant Prostate Cancer|Metastatic Prostate Carcinoma
Interventions: OTHER: Cytology Specimen Collection Procedure|OTHER: Laboratory Biomarker Analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Changing Habits in Anorexia Nervosa: Novel Treatment Development
Status: COMPLETED
Conditions: Anorexia Nervosa
Interventions: BEHAVIORAL: REACH|BEHAVIORAL: Supportive Psychotherapy|BEHAVIORAL: Inpatient Behavioral Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Dengue Tetravalent Vaccine (TDV) in Adults (Age 45 to 60 and >60 to 79 Years)
Status: NOT_YET_RECRUITING
Conditions: Dengue Fever
Interventions: BIOLOGICAL: TDV|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Capecitabine and Y-90 Radioembolization in Treating Patients With Advanced Bile Duct Cancer in the Liver That Cannot Be Removed by Surgery
Status: WITHDRAWN
Conditions: Bile Duct Adenocarcinoma|Stage III Intrahepatic Cholangiocarcinoma|Stage IVA Intrahepatic Cholangiocarcinoma|Stage IVB Intrahepatic Cholangiocarcinoma
Interventions: DRUG: Capecitabine|OTHER: Laboratory Biomarker Analysis|RADIATION: Radioembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Flapless Approach in Periodontal Regeneration
Status: COMPLETED
Conditions: Periodontitis, Adult|Intrabony Periodontal Defect
Interventions: PROCEDURE: Flapless with Enamel Matrix Derivatives (EMD)|PROCEDURE: Flapless without Enamel Matrix Derivatives (EMD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Rituximab for the Treatment for Idiopathic Membranous Nephropathy With Nephrotic Syndrome
Status: RECRUITING
Conditions: Glomerulonephritis, Membranous|Nephrotic Syndrome，Idiopathic
Interventions: DRUG: Rituximab (genetical recombination)|DRUG: Placebo|DRUG: Rituximab (genetical recombination)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Pharmacokinetics of Ramucirumab (IMC-1121B) in Combination With FOLFIRI
Status: COMPLETED
Conditions: Solid Tumors
Interventions: BIOLOGICAL: Ramucirumab (IMC-1121B)|DRUG: Irinotecan|DRUG: Folinic acid|DRUG: 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Bioequivalence Study of Wockhardt's Insulin Analogue Lispro (Listro™) With Humalog® in Healthy Subjects
Status: WITHDRAWN
Conditions: Bioequivalence in Healthy Subjects
Interventions: BIOLOGICAL: Insulin lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: CMV Immunity Monitoring in Lung Transplant Recipients
Status: NOT_YET_RECRUITING
Conditions: Lung Transplant; Complications
Interventions: DEVICE: Cytomegalovirus T Cell Immunity Panel (CMV-TCIP)|DIAGNOSTIC_TEST: Donor-Derived Cell-Free DNA (dd-cfDNA) Assay|DRUG: Valganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Migalastat in Fabry Subjects With Amenable GLA Variant and Renal Disease
Status: RECRUITING
Conditions: Fabry Disease
Interventions: DRUG: migalastat HCl 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Supplementation to Improve Anticoagulation Control With Oral Vitamin K as an Adjuvant to Warfarin Therapy
Status: COMPLETED
Conditions: Coagulation
Interventions: DIETARY_SUPPLEMENT: Vitamin K1 (Phytonadione)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DurAVR™ THV EU-EFS
Status: NOT_YET_RECRUITING
Conditions: Symptomatic Aortic Stenosis|Severe Aortic Valve Stenosis|Aortic Valve Calcification|Aortic Valve Failure|Aortic Valve Disease
Interventions: DEVICE: DurAVR™ THV System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Study of GSK3965193 in Healthy Participants and Participants Living With Chronic Hepatitis B Infection
Status: RECRUITING
Conditions: Hepatitis B
Interventions: DRUG: GSK3965193|DRUG: Placebo to match GSK3965193|DRUG: Bepirovirsen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Alpelisib in Healthy Volunteers
Status: COMPLETED
Conditions: Insulin Resistance|Hyperinsulinemia|Dyslipidemias
Interventions: DRUG: Alpelisib 150 mg [Piqray], 2 overencapsulated tablets (total: 300 mg)|DRUG: Placebo (microcrystalline cellulose), 2 capsules|DEVICE: FreeStyle Libre Pro|DIAGNOSTIC_TEST: Oral glucose tolerance test (OGTT) with Trutol glucose beverage|DIETARY_SUPPLEMENT: BOOST Plus nutritional beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pomalidomide Treatment in Patients With Kaposi Sarcoma
Status: RECRUITING
Conditions: Skin Kaposi Sarcoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Pomalidomide|PROCEDURE: X-Ray Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Roux-en-Y Gastric Bypass or Gastric Sleeve Surgery on Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Obesity
Interventions: PROCEDURE: Roux-en-Y Gastric Bypass|PROCEDURE: Gastric Sleeve
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Eloxatin+5-FU/LV in Patients With Unresectable Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Oxaliplatin|DRUG: Fluorouracil|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changing Opioid Users' Negative Attitudes Toward Medication Assisted Treatment
Status: WITHDRAWN
Conditions: Opioid Use Disorder
Interventions: BEHAVIORAL: MATTeRS Video|BEHAVIORAL: Didactic Video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of p38 MAPK Inhibitor POLB 001 on in Vivo LPS Challenge Responses
Status: COMPLETED
Conditions: Influenza, Human
Interventions: DRUG: POLB 001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Osteoarthritis Information on Treatment Beliefs
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: OTHER: Information on treatment options|OTHER: Recommendation from general practitioner|OTHER: Information on osteoarthritis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Registry Of Therapeutic EndoscopiC ulTrasound
Status: RECRUITING
Conditions: Gastric Outlet Obstruction|Biliary Obstruction|Acute Pancreatic Fluid Collection|Acute Pancreatitis With Infected Necrosis|Acute Cholecystitis|Chronic Pancreatitis
Interventions: PROCEDURE: Therapeutic EUS|PROCEDURE: Percutaneous Procedures|PROCEDURE: Surgical Interventions|PROCEDURE: non-EUS-based endoscopic procedures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of the Mass Balance of Oral FTD and TPI as Components of TAS-102 in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: TAS-102 with a light tracer dose of [14C]FTD|DRUG: TAS-102 with a light tracer dose of [14C] TPI|DRUG: TAS-102 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Perioperative Immune Enhancing Feed in Patients Undergoing Surgery for Head and Neck Cancer
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of Mouth|Squamous Cell Carcinoma of Oropharynx|Laryngeal Squamous Cell Carcinoma|Squamous Cell Carcinoma of the Hypopharynx
Interventions: DIETARY_SUPPLEMENT: IMPACT|DIETARY_SUPPLEMENT: An iso-caloric, iso-nitrogenous control feed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trauma-Informed Approach for Positive Youth Development for Montana Students
Status: COMPLETED
Conditions: Depression, Anxiety|Suicidal Ideation|Stress|Trauma
Interventions: OTHER: Trauma-Informed Yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]AZD9833
Status: COMPLETED
Conditions: ER-positive, HER2-negative Breast Cancer
Interventions: DRUG: [14C]AZD9833 Oral Solution, 75 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study to Compare the Bioavailability of Three Mometasone Furoate 0.1% Topical Lotions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Mometasone Furoate 0.1% Topical Lotion-Reference Product|DRUG: Mometasone Furoate 0.1% Topical Lotion-Test product 1|DRUG: Mometasone Furoate 0.1% Topical Lotion-Test Product 2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects Of Additional MgSO4 30 Mg/KgBW Intravenous and Ketorolac
Status: COMPLETED
Conditions: Anesthesia|Pain, Postoperative|Surgery|Opioid Use
Interventions: DRUG: MgSO4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single-cycle Remote Ischemic Preconditioning and Postconditioning for Prevention of Contrast-Induced Nephropathy
Status: UNKNOWN
Conditions: Ischemic Reperfusion Injury
Interventions: PROCEDURE: RIPre|PROCEDURE: RIPost|PROCEDURE: Sham-Pre|PROCEDURE: Sham-Post
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of SPI-1620 in Combination With Docetaxel Versus Docetaxel Alone for Patients With Non Small-cell Lung Cancer (NSCLC)
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer (NSCLC)
Interventions: DRUG: SPI-1620|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proglumide and Chemotherapy for Metastatic Pancreatic Cancer
Status: RECRUITING
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Nab paclitaxel|DRUG: Proglumide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Programme and Exercise Training in Combination or Separately on Managing Sarcopenic Obesity in Older Adults
Status: RECRUITING
Conditions: Sarcopenic Obesity
Interventions: BEHAVIORAL: The Individualized Dietary Behavioural Change Programme (IDBC)|BEHAVIORAL: The Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Bifidobacterium Adolescentis on Aging in Healthy Adults (45-65 Years)
Status: NOT_YET_RECRUITING
Conditions: Healthy Adults (45-65 Years)
Interventions: DIETARY_SUPPLEMENT: Bifidobacterium adolescentis|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Postoperative Analgesia in Patients With Microvascular Decompression
Status: UNKNOWN
Conditions: Trigeminal Neuralgia
Interventions: DRUG: Ketamine|OTHER: scalp nerve block|DRUG: ondansetron|DRUG: Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proton Pump Inhibitors and Gastrointestinal Symptoms
Status: COMPLETED
Conditions: Gastrointestinal Symptoms|Small Intestinal Overgrowth
Interventions: DIETARY_SUPPLEMENT: Lactobacillus paracasei F19|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Magnetic Resonance Imaging (MRI) Using Liverspecific Oral Contrast Agent in Metastatic Colorectal Cancer Patients
Status: WITHDRAWN
Conditions: Neoplasm Metastasis|Liver|Colorectal Neoplasms|Magnetic Resonance Imaging|Contrast Media
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dislocation Rates of Femoral Catheter Placed Sonographically Either In-plane or Out-of-plane
Status: COMPLETED
Conditions: Catheter Complications
Interventions: PROCEDURE: In-plane Group|PROCEDURE: Out-of-plane Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Weekly Taxotere and Topotecan for Recurrent Gynecologic (GYN) Cancers
Status: COMPLETED
Conditions: Ovarian Neoplasms|Uterine Neoplasms
Interventions: DRUG: Topotecan and Taxotere
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Communication Device in Home Care Services in Norway: Does Komp Make Older Adults Feel Happier, Safer and More Connected, and Able to Live Longer at Home.
Status: ACTIVE_NOT_RECRUITING
Conditions: Social Isolation|Well-being|Quality of Life|Mental Health|Dementia|Older Adults|Loneliness|Safety|Feeling Anxious|Technology|Home Care
Interventions: OTHER: Offer to try Komp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Ketamine on Opioid-Induced Hyperalgesia
Status: COMPLETED
Conditions: Pain|Chronic Pain|Hyperalgesia
Interventions: DRUG: Ketamine|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effectiveness and Tolerance of Fentanyl Citrate in Painful Pain Induced During Diagnostic or Therapeutic Examinations in Cancer Patients
Status: WITHDRAWN
Conditions: Breakthrough Pain
Interventions: DRUG: Fentanyl citrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Subcutaneous Injections of ASC to Heal Digital Ulcers in Patients With Scleroderma.
Status: RECRUITING
Conditions: Systemic Sclerosis
Interventions: DRUG: AdMSC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of RVX000222 on Time to Major Adverse Cardiovascular Events in High-Risk T2DM Subjects With CAD
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Coronary Artery Disease
Interventions: DRUG: Apabetalone|DRUG: Placebo|DRUG: Atorvastatin|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: FLOMAX® Versus HYTRIN® in Patients With the Signs and Symptoms of Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Prostatic Hyperplasia
Interventions: DRUG: FLOMAX® capsules|DRUG: Ascending doses of HYTRIN® capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STIM+: PET Biomarker Education & Disclosure
Status: ENROLLING_BY_INVITATION
Conditions: Mild Cognitive Impairment|Dementia; Alzheimer's Type (Etiology)
Interventions: BEHAVIORAL: PET Biomarker Disclosure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Trial to Assess the Lot Consistency, Safety, Tolerability and Immunogenicity of Bivalent rLP2086 Vaccine When Given to Healthy Subjects Aged ≥10 to <19 Years
Status: COMPLETED
Conditions: Meningococcal Vaccine
Interventions: BIOLOGICAL: rLP2086|BIOLOGICAL: rLP2086|BIOLOGICAL: rLP2086|BIOLOGICAL: Havrix (HAV)|BIOLOGICAL: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Reducing Sedentary Behaviour in Patients With Type II Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2|Sedentary Lifestyle
Interventions: BEHAVIORAL: Non-Sedentary Behaviour Modelling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Psychological and Neurobiological Impact of a Retreat Based on Mindfulness and Compassion for Stress Reduction.
Status: COMPLETED
Conditions: Mindfulness|Compassion|Psychophysiologic Reaction|Psychological Distress|Emotion Regulation|Stress
Interventions: BEHAVIORAL: Mindfulness-Based Stress Reduction|BEHAVIORAL: Compassion Cultivation Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nerve Grafting Technique to Restore Erectile Function Post Radical Prostatectomy
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer|Erectile Dysfunction Following Radical Prostatectomy
Interventions: PROCEDURE: Post radical prostatectomy nerve restoration procedure (PRP-NR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eltanexor (KPT-8602) With Inqovi (Decitabine-Cedazuridine) in High-Risk Myelodysplastic Syndromes
Status: RECRUITING
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: KPT-8602|DRUG: Inqovi
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deep Brain Stimulation of the Bilateral Nucleus Accumbens for Patients With Methadone Maintenance Treatment
Status: UNKNOWN
Conditions: Addiction Opiate
Interventions: PROCEDURE: Bilateral surgical implantation of DBS system to Nucleus Accumbens
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Delgocitinib Cream in Discoid Lupus Erythematosus.
Status: TERMINATED
Conditions: Discoid Lupus Erythematosus
Interventions: DRUG: Delgocitinib cream|DRUG: Delgocitinib cream vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ginger and Gut Microbiome (GINGER)
Status: COMPLETED
Conditions: Colorectal Adenoma
Interventions: DIETARY_SUPPLEMENT: Ginger extract|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess Pharmacokinetics (PK) of Preladenant in Participants With Chronic Renal Impairment (CRI) (P06512)
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Preladenant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evolut™ EXPAND TAVR II Pivotal Trial
Status: RECRUITING
Conditions: Moderate Aortic Valve Stenosis
Interventions: DEVICE: Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BMS-275291 in Treating Patients With Prostate Cancer That Has Not Responded to Hormone Therapy
Status: COMPLETED
Conditions: Adenocarcinoma of the Prostate|Bone Metastases|Hormone-resistant Prostate Cancer|Recurrent Prostate Cancer|Stage IV Prostate Cancer
Interventions: DRUG: rebimastat|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Kynurenine Aminotransferase Inhibition in People With Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder
Interventions: DRUG: N-acetylcysteine (NAC)|DRUG: Placebo|DRUG: Tryptophan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Behavioral Comparison of Three Different Graft Materials to Increase Soft Tissue Thickness Around Dental Implants.
Status: UNKNOWN
Conditions: Soft Tissue Atrophy|Mucogingival Deformity on Edentulous Ridge|Edentulous Alveolar Ridge
Interventions: PROCEDURE: Soft Tissue graft augmentation|PROCEDURE: Implant Placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Premature Ventricular Contractions (PVCs) and Blood Pressure Control
Status: TERMINATED
Conditions: Ventricular Premature Complexes|Blood Pressure
Interventions: DRUG: PVC Suppression using Flecainide|DRUG: No PVC Suppression using Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of MRI Diagnosed Meniscal Lesions
Status: COMPLETED
Conditions: Meniscus Lesion
Interventions: PROCEDURE: Arthroscopy|BEHAVIORAL: Non-invasive treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Diagnosis of Renal Cell Carcinoma on 68Ga-PSMA PET-CT and Radioligand Therapy With 177Lu-EB-PSMA-617
Status: UNKNOWN
Conditions: Renal Cell Carcinoma
Interventions: DRUG: 68Ga-PSMA|DRUG: 1.85GBq (50 mCi) of 177Lu-EB-PSMA-617
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Biliary Limb as a Percentage From the Small Intestine Rather Than Fixed Length in Loop Bypass Surgery for Morbid Obesity
Status: COMPLETED
Conditions: Obesity, Morbid
Interventions: OTHER: biliary limb as fixed length|OTHER: biliary limb as a percentage from small intestine length
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Evaluation of BST-CarGel Versus Microfracture Alone On Recovery From Distal Femoral Cartilage Lesions
Status: TERMINATED
Conditions: Traumatic; Lesion|Degenerative Lesion of Articular Cartilage of Knee
Interventions: PROCEDURE: Microfracture treatment|DEVICE: BST-CarGel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Metformin and Folate Supplementation in Polycystic Ovary Syndrome (PCOS) Patients
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Anovulation
Interventions: DRUG: Folate plus metformin|DRUG: Placebo plus metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Low-Molecular-Weight Heparin (LMWH) and Unfractionated Heparin (UFH) in Combination With Thrombolytic Treatment of Acute Massive Pulmonary Thromboembolism
Status: UNKNOWN
Conditions: This Study Will Provide Data Comparing Safety of LMWH Versus UFH in the Treatment of Acute PE Cases Who Require Thrombolytic Treatment.
Interventions: DRUG: enoxaparin ,alteplase, unfractionated heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Ascending Dose Pharmacokinetic (PK) and Absolute Bioavailability (BA)
Status: COMPLETED
Conditions: Bacterial Infections
Interventions: DRUG: TR-701 FA for injection, 200 mg/vial|DRUG: TR-701 FA tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of a PA Intervention for Fatness and Fitness in Adolescents With Intellectual Disability
Status: COMPLETED
Conditions: Obesity|Health-related Physical Fitness|Intellectual Disability
Interventions: BEHAVIORAL: School-based PA intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Protein Ingestion Timing on Body Composition and Biochemical Markers in Resistance-trained Males
Status: UNKNOWN
Conditions: Hypertrophy|Physical Performance
Interventions: DIETARY_SUPPLEMENT: isolate whey protein prior to and immediately after resistance training|DIETARY_SUPPLEMENT: isolate whey protein 3 hours prior to and 3 hours after resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: LLLT for Alopecia of the Eyebrow in Women
Status: COMPLETED
Conditions: Alopecia
Interventions: DEVICE: LLLT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quadratus Lumborum Block for Total Hip Arthroplasty
Status: RECRUITING
Conditions: Pain, Postoperative
Interventions: DRUG: Active Comparator|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ocular Effects of Carotid Endarterectomy
Status: UNKNOWN
Conditions: Choroid|Carotid Stenosis|Carotid Endarterectomy
Interventions: DEVICE: OCT swept source DRI-Atlantis, Topcon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Demonstrate the Relative Bioavailability of Bupropion HCI 100 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Bupropion HCl 100 mg Tablets (Invamed Inc.)|DRUG: Wellbutrin 100 mg Tablets (Glaxo Wellcome)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Oral Versus Intravenous Hypertonic Saline Administration in Runners With Exercise-Associated Hyponatremia
Status: UNKNOWN
Conditions: Exercise-associated Hyponatremia
Interventions: OTHER: Intravenous hypertonic Saline|OTHER: Oral hypertonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Fecal Microbiota Transplantation in Severe Obesity
Status: ENROLLING_BY_INVITATION
Conditions: Obesity, Morbid
Interventions: OTHER: Fecal microbiota transplantation|OTHER: Placebo: fecal microbiota transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Various Prosthetic Foot-Ankle Mechanisms
Status: ENROLLING_BY_INVITATION
Conditions: Transtibial Amputation - Unilateral
Interventions: DEVICE: MIT Variable Stiffness Prosthesis|DEVICE: MIT Variable Equilibrium Angle Prosthesis|DEVICE: MIT Sliding Beam Passive Prosthesis|DEVICE: Ossur Pro-flex XC|DEVICE: Blatchford Elan Variable-Dampening Prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin
Status: COMPLETED
Conditions: Clinical Stage III Human Papillomavirus (HPV)-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Locally Advanced Head and Neck Squamous Cell Carcinoma|Locally Advanced Hypopharyngeal Squamous Cell Carcinoma|Locally Advanced Laryngeal Squamous Cell Carcinoma|Locally Advanced Oral Cavity Squamous Cell Carcinoma|Locally Advanced Oropharyngeal Squamous Cell Carcinoma|Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Pathologic Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Stage III Hypopharyngeal Carcinoma AJCC v8|Stage III Laryngeal Cancer AJCC v8|Stage III Lip and Oral Cavity Cancer AJCC v8|Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IV Hypopharyngeal Carcinoma AJCC v8|Stage IV Laryngeal Cancer AJCC v8|Stage IV Lip and Oral Cavity Cancer AJCC v8|Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IVA Hypopharyngeal Carcinoma AJCC v8|Stage IVA Laryngeal Cancer AJCC v8|Stage IVA Lip and Oral Cavity Cancer AJCC v8|Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IVB Hypopharyngeal Carcinoma AJCC v8|Stage IVB Laryngeal Cancer AJCC v8|Stage IVB Lip and Oral Cavity Cancer AJCC v8|Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IVC Hypopharyngeal Carcinoma AJCC v8|Stage IVC Laryngeal Cancer AJCC v8|Stage IVC Lip and Oral Cavity Cancer AJCC v8|Stage IVC Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Interventions: DRUG: Cisplatin|OTHER: Hearing Handicap Inventory for Adults - Screening|RADIATION: Radiation Therapy|DRUG: Sodium Thiosulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase II Randomized Trial for Early-stage Squamous Cell Carcinoma of the Oropharynx: Radiotherapy vs Trans-oral Robotic Surgery (ORATOR)
Status: ACTIVE_NOT_RECRUITING
Conditions: Early-Stage Squamous Cell Carcinoma of the Oropharynx
Interventions: RADIATION: Radiotherapy|PROCEDURE: Transoral Robotic Surgery + Neck Dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
Status: NOT_YET_RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Clinical Stage IV Cutaneous Melanoma AJCC v8|Metastatic Breast Carcinoma|Metastatic Digestive System Carcinoma|Metastatic Lung Non-Small Cell Carcinoma|Metastatic Malignant Neoplasm in the Brain|Metastatic Malignant Solid Neoplasm|Metastatic Melanoma|Metastatic Renal Cell Carcinoma|Stage IV Lung Cancer AJCC v8|Stage IV Renal Cell Cancer AJCC v8
Interventions: PROCEDURE: Computed Tomography|RADIATION: Fractionated Stereotactic Radiation Therapy|PROCEDURE: Magnetic Resonance Imaging|RADIATION: Stereotactic Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Breast Cancer Survivors and Partners Online Research Together (SUPORT) Project
Status: RECRUITING
Conditions: Breast Cancer Female|Psychological Distress
Interventions: BEHAVIORAL: Cognitively-Based Compassion Training for Survivors|BEHAVIORAL: Cognitively-Based Compassion Training for Dyads|BEHAVIORAL: Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Methodology Study Of Brain Imaging Of Pain-Killers In Post-Traumatic Neuropathic Pain Patients
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Placebo|DRUG: Pregabalin|DRUG: Tramadol SR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Botulinum Toxin Type A in Adults With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: DRUG: Botulinum toxin type A (Botox)|DRUG: placebo (saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Let's Empower and Prepare Young Adults With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: BEHAVIORAL: Transition Empowerment Program|BEHAVIORAL: Transition Empowerment Program (TEP) + Diabetes Wellness Council (DWC)|BEHAVIORAL: Online Transition Empowement Program Access
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Two Bladder Catheterization Strategies in Thoracic Surgery Patients With an Enhanced Recovery After Surgery (ERAS)
Status: RECRUITING
Conditions: Urinary Retention|Chronic Kidney Infection|Urinary Infection
Interventions: PROCEDURE: Systematic Intermittent Catheterization|PROCEDURE: Bladder Scan Guided Catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Aromatherapy for Stress and Burnout Among Healthcare Providers
Status: COMPLETED
Conditions: Stress|Burnout, Professional|Stress, Job
Interventions: OTHER: Herbaceous Essential Oil Blend|OTHER: Citrus Essential Oil Blend|OTHER: Inert Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diet Rich in N-3 Polyunsaturated Fatty Acids in Renal Transplant Recipients
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DIETARY_SUPPLEMENT: n-3 rich diet|DIETARY_SUPPLEMENT: Usual diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Treatment Effect of Minimally Invasive Spinal Fusion Surgery
Status: UNKNOWN
Conditions: Spinal Fusion
Interventions: DEVICE: bone graft delivery system/wiltrom interbody fusion system/wiltrom spinal fixation system|DEVICE: wiltrom interbody fusion system/wiltrom spinal fixation system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of GSK1358820 In Patients With Post-Stroke Lower Limb Spasticity
Status: COMPLETED
Conditions: Post-Stroke Spasticity|Cerebrovascular Accident
Interventions: DRUG: GSK1358820|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of RIPC on the Prevention of POD in Patients Undergoing Cardiac Surgery
Status: UNKNOWN
Conditions: Postoperative Delirium|Cardiac Surgery
Interventions: DEVICE: RIPC induced with 3 cycles of 5 minutes of ischaemia and 5 minutes of reperfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Pumpkin Seed Extract on Improving Blood Sugar Level in Subhealth Subjects
Status: RECRUITING
Conditions: Diabetes|Metabolic Disease
Interventions: DIETARY_SUPPLEMENT: Pumpkin seed extract (Low dose)|DIETARY_SUPPLEMENT: Pumpkin seed extract (High dose)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of BLEX 404 Oral Liquid in Patients With International Prognostic Scoring System (IPSS) Intermediate-1, Intermediate-2 or High-Risk Myelodysplastic Syndrome (MDS) and Chronic Myelomonocytic Leukemia (CMML)
Status: NOT_YET_RECRUITING
Conditions: Myelodysplastic Syndrome (MDS)
Interventions: DRUG: BLEX 404 Oral Liquid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT