pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Ergospirometric Values and WBV in Elderly
Status: COMPLETED
Conditions: Aging
Interventions: DEVICE: WBV and Resistance|DEVICE: resistance & sham WBV|DEVICE: WBV & resistance sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Hemophilia A Patients With FVIII Inhibitors
Status: RECRUITING
Conditions: Hemophilia A
Interventions: BIOLOGICAL: Nuwiq|BIOLOGICAL: Octanate|BIOLOGICAL: Wilate|BIOLOGICAL: Emicizumab|BIOLOGICAL: Recombinant factor VIIa (rFVIIa)|BIOLOGICAL: Activated prothrombin complex concentrate (aPCC)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating the Efficacy of GPT-based Nutrition and Diabetic Counseling in Gestational Diabetes Management: A Randomized Controlled Trial (AIM-GDM)
Status: NOT_YET_RECRUITING
Conditions: Gestational Diabetes
Interventions: DEVICE: GPT-based counseling|OTHER: Nutritional Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Oral Feeding Model With a Chronobiological Approach in Preterm Infants
Status: COMPLETED
Conditions: Breastfeeding|Bottle Feeding|Preterm|Chronobiology Disorders
Interventions: PROCEDURE: Chronobiological Approach Nutrition Model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Digital Intervention for the Modification of Lifestyles (iGame)
Status: ENROLLING_BY_INVITATION
Conditions: Low Back Pain|Oncology|Depression|Sedentary Lifestyle|Sedentary Behavior
Interventions: BEHAVIORAL: Digital intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy(Immunogenicity) of GC3114 in Elderly Healthy Subjects
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: GC3114|BIOLOGICAL: GCFLU Quadrivalent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Subconjunctiva Bupivacaine as Analgesia in Intravitreal Silicone Oil Removal
Status: COMPLETED
Conditions: Retinal Detachment
Interventions: DRUG: Bupivacaine 0,5%|DRUG: NaCl 0,9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison Between LISS Plating and Intramedullary (IM) Nailing for Supracondylar Femur Fractures
Status: COMPLETED
Conditions: Supracondylar Femur Fracture
Interventions: PROCEDURE: IM Nailing|PROCEDURE: LISS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Long-term Safety and Tolerability of an Investigational Drug in People With Schizophrenia.
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: SEP363856|DRUG: quetiapine XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neck and Shoulder Pain Research Study
Status: COMPLETED
Conditions: Neck Pain|Shoulder Pain|Chronic Pain|Musculoskeletal Pain
Interventions: DEVICE: Multi Radiance Medical®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial for PB-119 in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type II Diabetes Mellitus
Interventions: BIOLOGICAL: Exenatide injection(Byetta)|BIOLOGICAL: PB-119 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Investigate Teprotumumab Subcutaneous Administration Compared With Placebo in Male and Female Adult Participants With Moderate-to-severe Active Thyroid Eye Disease
Status: RECRUITING
Conditions: Thyroid Eye Disease
Interventions: BIOLOGICAL: Teprotumumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Research Study Looking Into Blood Levels of the Medicine NNC0519-0130 in the Body in Participants With Normal or Reduced Kidney Function
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: NNC0519-0130
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Apatinib Plus Docetaxel for Treatment of Advanced Non-squamous Non-small Cell Lung Cancer With Bone Metastases
Status: UNKNOWN
Conditions: Non-squamous Non-small Cell Lung Cancer
Interventions: DRUG: apatinib docetaxel zoledronic|DRUG: docetaxel zoledronic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aerosolized and Intravenous Colistin in Healthy Adults
Status: TERMINATED
Conditions: Pathogen Resistance|Pneumococcal Infection|Pneumonia
Interventions: DRUG: Colistimethate sodium|DRUG: Colistimethate sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Radical Radiotherapy to Prostate Only VS Prostate And Pelvic Lymph Nodes in Intermediate And High Risk Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: RADIATION: Prostate Only Radiation|RADIATION: Prostate and Pelvic Lymph Node Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Trial of JCAR017 Combinations in Subjects With Relapsed/Refractory B-cell Malignancies
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin|Lymphoma, Large B-Cell, Diffuse|Lymphoma, Follicular
Interventions: BIOLOGICAL: JCAR017|DRUG: Durvalumab|DRUG: CC-122|DRUG: Ibrutinib|DRUG: CC-220|DRUG: Relatlimab|DRUG: Nivolumab|DRUG: CC-99282
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ga68 Αvβ3 IAC PET/CT for Diagnosis and Clinical Management in Angiogenic Breast Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: Angiogenic Breast Cancer
Interventions: DIAGNOSTIC_TEST: Ga-68-PEG-Αvβ3-IAC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Biorepository of Biospecimen Samples in Matched Healthy Control Participants and Participants Diagnosed With Diabetic Kidney Disease, Chronic Kidney Disease, or Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetic Kidney Disease|Diabetes Type 2|Chronic Kidney Diseases|Healthy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of BCT197 in Subjects With Acute Respiratory Exacerbations of Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: BCT197|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab Plus Tremelimumab for the Treatment of Patients With Progressive, Refractory Advanced Thyroid Carcinoma -The DUTHY Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Thyroid Papillary Carcinoma|Metastatic Thyroid Follicular Carcinoma|Metastatic Thyroid Cancer
Interventions: DRUG: Durvalumab|DRUG: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Immunogenicity of Intranasal Nanoemulsion Adjuvanted Recombinant Pandemic Flu Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Influenza, Pandemic
Interventions: BIOLOGICAL: BW-1014: 25 µg rH5 in 20% NE - pipette - IN|BIOLOGICAL: BW-1014: 50 µg rH5 in 20% NE - pipette - IN|BIOLOGICAL: BW-1014: 100 µg rH5 in 20% NE - pipette - IN|BIOLOGICAL: rH5 (100 µg) control - pipette - IN|BIOLOGICAL: Saline (Placebo) - pipette - IN|BIOLOGICAL: H5N1 IIV - IM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate a Preop Dose of Brivoligide Injection for Pain After Mastectomy in Patients With High PCS Scores
Status: WITHDRAWN
Conditions: Pain, Postoperative
Interventions: DRUG: Brivoligide Injection 660 mg/6 mL|DRUG: Placebo 6 mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Trial of Multiple Dosing Regimens of ABT-719 for the Prevention of Acute Kidney Injury in Subjects Undergoing High Risk Surgery
Status: TERMINATED
Conditions: Cardiothoracic Surgery|Vascular Surgery
Interventions: DRUG: Placebo|DRUG: ABT-719
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessing Minimal Residual Disease by Next- Generation Sequencing to Minimize Exposure in People With CLL or SLL Who Have Been Treated With Venetoclax
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia (CLL)|Small Lymphocytic Lymphoma (SLL)
Interventions: DRUG: Venetoclax monotherapy|DRUG: Venetoclax with anti CD20 monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Injection Site Pain Botulinum Toxin Reconstituted in NS With and Without Sodium Bicarbonate
Status: COMPLETED
Conditions: Wrinkle
Interventions: DRUG: Sodium Bicarbonate|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance Assessment of a Daily Wear Monthly Replacement Soft Silicone Hydrogel Contact Lens
Status: COMPLETED
Conditions: Refractive Errors
Interventions: DEVICE: Lehfilcon A contact lenses|DEVICE: Comfilcon A contact lenses|DEVICE: Multi-purpose disinfection solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Chimeric Antigen Receptor T Lymphocytes (CAR-T) in the Treatment of Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Anti-CLL1 CART cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arresting Active Dental Caries in Preschool Children by Topical Fluorides
Status: COMPLETED
Conditions: Dental Caries
Interventions: DEVICE: SDF solution|DEVICE: NaF varnish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Transdiagnostic Online Prevention Approach in Adolescents (EMPATIA)
Status: RECRUITING
Conditions: Mental Health Issue|Transdiagnostic Mechanisms|Adolescent Psychology|Prevention|Online Intervention|Psychological Intervention|Mental Disorder in Adolescence, Subclinical
Interventions: DEVICE: EMPATIA 1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 2 Study of the Combination of Bruton's Tyrosine Kinase Inhibitor PCI-32765 and Rituximab in High-Risk Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma Patients
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Rituximab|DRUG: PCI-32765
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wheat Flour Treatment With Microbial Transglutaminase and Lysine Ethyl Ester: New Frontiers in Celiac Disease Treatment.
Status: UNKNOWN
Conditions: Celiac Disease
Interventions: DIETARY_SUPPLEMENT: rusks made of wheat flour enzymatically treated|DIETARY_SUPPLEMENT: rusks made of wheat flour not enzimatically modified|DIETARY_SUPPLEMENT: Gluten-free diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Mint Flavored Chewing Gum on Hyperemesis Gravidarum Nausea Vomiting Severity, Coping With Stress and Anxiety Level in Pregnants With Hyperemesis Gravidarum
Status: RECRUITING
Conditions: Hyperemesis Gravidarum
Interventions: OTHER: chewing gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Fiit-ns® in Health-related Quality of Life Improvement in Overweight and Obese Subjects
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: Fiit-ns®|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fenoldopam and Ketanserin for Acute Kidney Failure Prevention After Cardiac Surgery
Status: TERMINATED
Conditions: Acute Renal Failure
Interventions: DRUG: fenoldopam (Corlopam)|DRUG: placebo|DRUG: ketanserin (Sufrexal)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Study to Test the Efficacy of the PRO-SELF® Plus Pain Control Program to Reduce Pain in Outpatients With Cancer
Status: TERMINATED
Conditions: Pain Management
Interventions: BEHAVIORAL: Adapted German PRO-SELF© Plus Pain Control Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of ADXS-503 With or Without Pembro in Subjects With Metastatic Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer, Non-Small Cell|Metastatic Squamous Cell Carcinoma|Metastatic Non-Squamous Cell Carcinoma
Interventions: DRUG: ADXS-503|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial in Elderly Patients With AML or MDS in Complete Remission Not Eligible for Allogenic Transplant
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes|Transplant-Related Hematologic Malignancy
Interventions: DRUG: Fludarabine|DRUG: ARA-C|DRUG: Treosulfan|PROCEDURE: Peripheral Blood Stem Cell Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Manual Therapy and Exercise vs Exercise in Subjects With Chronic Cervical Pain and Upper Cervical Spine Dysfunction
Status: COMPLETED
Conditions: Neck Pain|Cervical Pain
Interventions: OTHER: Manual Therapy and Exercise|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Weight Loss on Anti-Müllerian Hormone Levels in Women With Polycystic Ovary Syndrome (PCOS)
Status: UNKNOWN
Conditions: Obesity|Polycystic Ovaries Syndrome
Interventions: DRUG: Orlistat|DRUG: Sibutramine|BEHAVIORAL: Diet and physical exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Ultrasound Cavitation Versus Electrolipolysis on Obese Infertile Women With Polycystic Ovarian Syndrome
Status: NOT_YET_RECRUITING
Conditions: Polycystic Ovary Syndrome
Interventions: DEVICE: Electrolipolysis|DEVICE: ultrasound cavitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Explore the Efficacy and Safety of Tislelizumab in Combination With Bevacizumab and Chemotherapy in Patients With Persistent, Recurrent, or Metastatic Cervical Cancer
Status: RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: Tislelizumab / Bevacizumab/Paclitaxel/Cisplatin/Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: T-Lymphocytes in Treating Patients With Epstein-Barr Virus-Positive Nasopharyngeal Cancer, NPC
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: autologous EBV specific CTLs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Diabetes Transition Study for Young People Aged Between 16-20 Years of Age.
Status: UNKNOWN
Conditions: Type 1 Diabetes Mellitus
Interventions: OTHER: Transition intervention group|OTHER: Post transition group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Long-Term Non-Interventional Study (NIS) To Investigate The Safety And Effectiveness Of MACUGEN In Patients With Neovascular Age-Related Macular Degeneration Under Conditions Of Routine Clinical Practice
Status: COMPLETED
Conditions: Age-related Macular Degeneration
Interventions: OTHER: no intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of a Two-tiered Cross-age Teaching Model for Food Literacy-based Education
Status: TERMINATED
Conditions: Food Literacy; Adolescent Health; Cross-age Teaching; Nutrition Education; Experiential Learning
Interventions: BEHAVIORAL: Science for Life
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Canadian HIV Quit Smoking Trial: Tackling the Co-morbidities of Depression and Cardiovascular Disease in HIV+ Smokers
Status: UNKNOWN
Conditions: HIV|Smoking Cessation
Interventions: DRUG: Nicotine Replacement Therapy (NRT)|DRUG: Varenicline|BEHAVIORAL: HIV Tailored Quit Smoking Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multisite Advancement of Research on Chronic Posttraumatic Headache
Status: RECRUITING
Conditions: Posttraumatic Headache
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Posttraumatic Headache|OTHER: Treatment as Usual|OTHER: Telemedicine-based Cognitive Behavioral Therapy (TCBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of the Individual Challenge Inventory Tool (ICIT) by General Practitioners
Status: COMPLETED
Conditions: Medical Unexplained Physical Symptoms (MUPS)|Subjective Health Complaint
Interventions: BEHAVIORAL: ICIT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Exploring the Feasibility of Kōmmour Prenatal to Reduce Maternal and Infant Health Disparities
Status: RECRUITING
Conditions: Kōmmour Prenatal Among Marshallese Pregnant Women
Interventions: BEHAVIORAL: Kōmmour Prenatal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety in Chinese Patients With Immunoglobulin A Nephropathy (IgAN) Who Have Completed Study Nef-301
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Immunoglobulin A Nephropathy (IgAN)
Interventions: DRUG: Nefecon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ropivacaine Volume for Ultrasound-guided Retrograde Infraclavicular Brachial Plexus Block
Status: COMPLETED
Conditions: Upper Extremity Injury Trauma
Interventions: PROCEDURE: appropriate volume of 0.5% ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Evaluating the Efficacy of Dextromethorphan/Quinidine in Treating Irritability in Huntington's Disease
Status: COMPLETED
Conditions: Huntington Disease|Irritability
Interventions: DRUG: Dextromethorphan/quinidine 20mg/10mg (DM/Q 20mg/10mg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Consumption of 4D Dietary Supplement on Perceptual-Cognitive and Visual-Motor Performance
Status: COMPLETED
Conditions: Dietary Supplementation
Interventions: DIETARY_SUPPLEMENT: 4D|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: ATP and P2X3 Receptor in Chronic Cough
Status: NOT_YET_RECRUITING
Conditions: Cough
Interventions: DEVICE: Adenosine triphosphate (ATP) solution inhalation from nebuliser|DIAGNOSTIC_TEST: Inhalational challenge with increasing concentrations of capsaicin solutions|DEVICE: Recording of Cough Count and frequency using the Hyfe Cough Monitor|PROCEDURE: Collection of exhaled breath condensate|DIAGNOSTIC_TEST: Continuous laryngoscopic examination|DIAGNOSTIC_TEST: Sputum induction|DIAGNOSTIC_TEST: Spirometric measurements|DIAGNOSTIC_TEST: Blood sample collection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Novara Registry of Platinum-Chromium Platform Stents
Status: UNKNOWN
Conditions: Fracture of Stent of Coronary Artery|External Causes of Morbidity and Mortality|Myocardial Infarction|Coronary Vessel Disorders
Interventions: DEVICE: coronary angioplasty with PtCr stent implantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Pembrolizumab (MK-3475) Plus Olaparib Versus Abiraterone Acetate or Enzalutamide in Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-7339-010/KEYLYNK-010)
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Olaparib|DRUG: Abiraterone acetate|DRUG: Prednisone|DRUG: Enzalutamide|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antibiotic Treatment Of Staphylococcus Aureus In Stable People With CF
Status: RECRUITING
Conditions: Cystic Fibrosis
Interventions: DRUG: Cephalexin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mission Reconnect: Promoting Resilience and Reintegration of Post-Deployment Veterans and Their Families
Status: COMPLETED
Conditions: Stress|Depression|PTSD|Sleep|Compassion
Interventions: BEHAVIORAL: Mission Reconnect|BEHAVIORAL: PREP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Remote Yoga Nidra for Deprescribing BZRAs
Status: NOT_YET_RECRUITING
Conditions: Anxiety|Insomnia
Interventions: OTHER: Yoga Nidra|OTHER: Sleep Hygiene, Anxiety, and Benzodiazepine Receptor Agonist Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Dengzhanxixin Capsule on Platelet Function in Individuals at High Risk for Cardiovascular Disease
Status: RECRUITING
Conditions: Diabetes|Hypertension|Hypercholesterolemia
Interventions: DRUG: Dengzhanxixin Capsule plus Placebo Capsule|DRUG: Placebo|DRUG: Dengzhanxixin Capsule plus Placebo Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Comparing Vemurafenib Versus Vemurafenib Plus Cobimetinib in Participants With Metastatic Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: DRUG: Placebo|DRUG: Vemurafenib|DRUG: Cobimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Topical Dexamethasone Versus Artificial Tears for Treatment of Viral Conjunctivitis
Status: COMPLETED
Conditions: Viral Conjunctivitis
Interventions: DRUG: dexamethasone 0.1%/povidone-iodine 0.4%|DRUG: Artificial Tears
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of an Estrogen Replacement Therapy Skin Patch on Ovulation in Women With Premature Ovarian Failure
Status: WITHDRAWN
Conditions: Premature Ovarian Failure
Interventions: DRUG: Estradiol/Medroxyprogesterone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
Status: UNKNOWN
Conditions: Leukemia
Interventions: DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: pegaspargase|DRUG: thioguanine|DRUG: vincristine sulfate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The INFUSE Trial - Intervening With Platelet Transfusions in Sepsis
Status: WITHDRAWN
Conditions: Sepsis|Thrombocytopenia
Interventions: BIOLOGICAL: Platelet transfusion|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carbon Dye Tattooing of Biopsied Axillary Node in Breast Cancer
Status: COMPLETED
Conditions: Sentinel Lymph Node|Breast Cancer|Tattoo; Pigmentation|Axilla; Breast
Interventions: PROCEDURE: Tattooing of biopsied node
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Gefitinib, in Subjects With EFGR Amplification Refractory Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Cord Blood Stem Cells for Autism
Status: COMPLETED
Conditions: Autism
Interventions: BIOLOGICAL: Autologous Cord Blood Stem Cells|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Antibody Persistence in Children Previously Vaccinated With Pneumococcal Conjugate Vaccine
Status: COMPLETED
Conditions: Infections, Streptococcal|Streptococcus Pneumoniae Vaccines
Interventions: BIOLOGICAL: GSK1024805A|BIOLOGICAL: Prevenar|BIOLOGICAL: Infanrix hexa|BIOLOGICAL: Havrix|BIOLOGICAL: Varilrix
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Lidocaine Versus Bupivacaine in Ambulatory Continuous Block With Elastomeric Pump
Status: COMPLETED
Conditions: Hallux Valgus
Interventions: DRUG: Lidocaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Control of COVID-19 Outbreaks in Long Term Care
Status: TERMINATED
Conditions: COVID-19|SARS-CoV-2
Interventions: DRUG: Favipiravir|DRUG: Favipiravir Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Methylprednisolone Pulse Therapy for Coronary Artery Dilatation or Aneurysm Formation in Kawasaki Disease
Status: UNKNOWN
Conditions: Mucocutaneous Lymph Node Syndrome
Interventions: DRUG: Methylprednisolone Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Saracatinib in the Treatment of Idiopathic Pulmonary Fibrosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis (IPF)
Interventions: DRUG: Saracatinab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Roux-en-Y Gastric Bypass: Clinical Trial
Status: UNKNOWN
Conditions: Obesity
Interventions: PROCEDURE: GASTRIC BYPASS MODIFIED IN ROUX-EN-Y AS A THERAPEUTIC OPTION IN PATIENTS WITH INDICATION OF BARIATRIC AND / OR METABOLIC SURGERY
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Maximal Usage Pharmacokinetics and Safety of ARQ-151 in Adolescents and Adults With Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: ARQ-151- cream 0.3%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study Using MEDI-551 in Adult Participants With Relapsed or Refractory Advanced B-Cell Malignancies
Status: COMPLETED
Conditions: B-cell Malignancies|Cancer
Interventions: DRUG: MEDI-551|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zoledronic Acid in the Prevention of Skeletal-related Events in Hormone Refractory and Hormone-sensitive Prostate Cancer Patients With Bone Metastases
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Interactions and Safety Between Exforge Tab. and Crestor Tab. in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: administration of exforge 10/160mg for 3days. Next 7days administration of exforge 10/160mg and crestor 20mg.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of N-acetylcysteine on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass Graft
Status: COMPLETED
Conditions: Postoperative Acute Kidney Injury After Off-pump Coronary Artery Bypass Graft
Interventions: DRUG: N-acetylcysteine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 1b/2 Study of TTI-101 in Combination for Patients With Metastatic Hormone Receptor-Positive and HER2-Negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: TTI-101|DRUG: Palbociclib|DRUG: Aromatase inhibitor (AI)|DRUG: fulvestrant|DRUG: ribociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PART A: Efficacy and Safety of AEVI-001 in Children and Adolescents With ADHD and With mGluR Mutations
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: AEVI-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: T-Guard as Treatment for Steroid Refractory Acute GVHD (BMT CTN 1802)
Status: TERMINATED
Conditions: Steroid-Refractory Acute Graft Versus Host Disease
Interventions: DRUG: T-Guard
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Music Listening in Rehabilitation of Subacute Stroke
Status: NOT_YET_RECRUITING
Conditions: Ischemic Stroke|Intracerebral Hemorrhage
Interventions: BEHAVIORAL: Music listening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Monoclonal Antibody, Nimotuzumab, as Treatment for Recurrent or Metastatic Cervical Cancer
Status: COMPLETED
Conditions: Uterine Cervical Cancer
Interventions: DRUG: Nimotuzumab|DRUG: Cisplatin|DRUG: Gemcitabine|PROCEDURE: CT Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Venetoclax on Ethinyl Estradiol and Levonorgestrel in Female Participants With Different Hematological Malignancies
Status: RECRUITING
Conditions: Hematologic Malignancies
Interventions: DRUG: Venetoclax|DRUG: ethinyl estradiol/levonorgestrel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Use of CoSeal (Sealant Agent) in Patients During Left Ventricular Assist Device Surgery
Status: TERMINATED
Conditions: Heart Failure|Ventricular Dysfunction
Interventions: DEVICE: CoSeal|DEVICE: BioGlue® Surgical Adhesive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Say When: Targeting Heavy Alcohol Use With Naltrexone Among MSM
Status: COMPLETED
Conditions: Binge Drinking|HIV
Interventions: DRUG: Placebo|DRUG: Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of MIB-626 With and Without A High-Intensity Multi-Dimensional Exercise Training Program
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: Investigational Product - MIB 626|DRUG: Placebo|OTHER: Standardized, progressive, high intensity, multidimensional exercise|OTHER: Usual Physical Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Double Blind Study Evaluating Duloxetine in Outpatients With MDD and Pain
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Duloxetine Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Mirtazapine to Treat Interferon-related Depression During Antiviral Therapy for Hepatitis C
Status: TERMINATED
Conditions: Depression
Interventions: DRUG: Mirtazapine|OTHER: Supportive psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Electrical Nerve Field Stimulation for Adults With Irritable Bowel Syndrome
Status: RECRUITING
Conditions: Irritable Bowel Syndrome|Abdominal Pain|Autonomic Nervous System Imbalance
Interventions: DEVICE: Peripheral Electrical Nerve Field Stimulation (PENFS) Device|DEVICE: Sham Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intraarticular Analgesia After Total Hip Arthroplasty, a Randomised Study
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Hip
Interventions: DRUG: Epidural Ropivacaine, morphine|DRUG: Ropivacaine, Ketorolac and Adrenaline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Superior Vena Cava Isolation Plus Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Pulmonary vein isolation plus superior vena cava isolation|PROCEDURE: Pulmonary vein isolation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess Zibotentan Pharmacokinetics in Participants With Moderate Hepatic and Moderate Renal Impairment
Status: COMPLETED
Conditions: Hepatic Impairment|Renal Impairment
Interventions: DRUG: Zibotentan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant or Adjuvant Epirubicin, Cyclophosphamide, and Paclitaxel in Treating Women With Stage I, Stage II, or Stage III Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: cyclophosphamide|DRUG: epirubicin hydrochloride|DRUG: paclitaxel|PROCEDURE: adjuvant therapy|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Double Blind Randomized Controlled Evaluation of the HBLPADD-coil Transcranial Magnetic Stimulation (TMS) Device - Efficacy and Safety In Subjects With ADHD.
Status: UNKNOWN
Conditions: ADHD
Interventions: DEVICE: HBLPADD coil deep TMS|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Visual Retraining After Stroke
Status: ACTIVE_NOT_RECRUITING
Conditions: Vision Loss Partial|Vision; Loss, Both Eyes|Hemianopia Homonymous|Hemianopia|Quadrantanopia|Stroke, Ischemic|Stroke - Occipital Infarction|Cortical Blindness
Interventions: DEVICE: Training in the Blind Field
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Staphylococcus Aureus Network Adaptive Platform Trial
Status: RECRUITING
Conditions: Staphylococcus Aureus Bacteremia
Interventions: DRUG: Cefazolin|DRUG: Penicillin|DRUG: Clindamycin|DRUG: Vancomycin|OTHER: Effectiveness of early switch to oral antibiotics|RADIATION: Whole body FDG PET/CT Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Intracerebral Hemorrhage With Aminocaproic Acid - Pilot Study
Status: WITHDRAWN
Conditions: Intracerebral Hemorrhage
Interventions: DRUG: ɛ-Aminocaproic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study To Evaluate The Efficacy And Safety Of PH-797804 For 12 Weeks In Adults With Moderate To Severe Chronic Obstructive Pulmonary Disease (COPD) On A Background Of Tiotropium Bromide
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: PH-797804|DRUG: PH-797804|DRUG: PH-797804|DRUG: PH-797804|DRUG: PH-797804|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Health Disparities for Black Women in the Treatment of Insomnia
Status: COMPLETED
Conditions: Insomnia
Interventions: BEHAVIORAL: SHUTi|BEHAVIORAL: modified SHUTi (i.e., SHUTi-BWHS)|BEHAVIORAL: Patient education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Optimized Treatment of Pulmonary Edema or Congestion
Status: RECRUITING
Conditions: Pulmonary Edema|Congestive Heart Failure|Acute Heart Failure
Interventions: DRUG: Furosemide Injection|DRUG: Isosorbide Dinitrate|DRUG: Furosemide and isosorbide dinitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of PRISM-5-Op, Measure Of Addiction To Prescription Opioid Medication
Status: COMPLETED
Conditions: Opioid-Related Disorders|Opiate Addiction|Narcotic Abuse|Drug Abuse
Interventions: OTHER: Psychiatric Research Interview for Substance and Mental Disorders (PRISM-5-Op)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessments in Patients With Muscular Pathology and in Control Subjects : The ActiLiège Next Study
Status: RECRUITING
Conditions: Duchenne Muscular Dystrophy|Fascioscapulohumeral Muscular Dystrophy|Myotonic Dystrophy 1|Charcot-Marie-Tooth|Centronuclear Myopathy|Congenital Muscular Dystrophy
Interventions: DEVICE: ActiMyo/Syde
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Binge Eating Disorder and Obesity : Functional MRI Study
Status: COMPLETED
Conditions: Binge Eating Disorder|Obesity
Interventions: OTHER: Functional MRI|OTHER: ADO-BEDS scale|OTHER: R-CMAS scale
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Pilot Study of Metformin to Reduce Cerebrovascular Dysfunction in Participants With HIV and Metabolic Syndrome.
Status: RECRUITING
Conditions: Metabolic Syndrome|HIV Seropositivity
Interventions: DRUG: Metformin Extended Release Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hoosier Sport Re-Social: A Biobehavioral Intervention in Rural Indiana
Status: NOT_YET_RECRUITING
Conditions: CVD|Sedentary Behavior
Interventions: BEHAVIORAL: Hoosier Sport Re-Social
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase 2 - Rhythmic Light Therapy for Alzheimer's Disease Patients
Status: RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: DEVICE: Circadian-Effective Light|DEVICE: Rhythmic Light|DEVICE: Placebo Light|DEVICE: Placebo Rhythmic Light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Adding Adefovir Dipivoxil and Nelfinavir to the Anti-HIV Therapy of HIV-Infected Children
Status: UNKNOWN
Conditions: HIV Infections
Interventions: DRUG: Nelfinavir mesylate|DRUG: Levocarnitine|DRUG: Adefovir dipivoxil
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Active Intervention in High-risk HFpEF Patients
Status: NOT_YET_RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: OTHER: Targeted intervention based on risk factors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: SubQStim: A Post-market Study of Subcutaneous Nerve Stimulation in Failed Back Surgery Syndrome (FBSS) Patients
Status: TERMINATED
Conditions: Failed Back Surgery Syndrome
Interventions: DEVICE: subcutaneous nerve stimulation|OTHER: Optimized Medical Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Engagement and Usefulness of Care4Today Digital Platform for Disease Management in Coronary Artery Disease (CAD) and/or Peripheral Artery Disease (PAD) Population
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease (CAD)|Peripheral Artery Disease (PAD)
Interventions: DEVICE: Care4Today® Connect CAD-PAD Mobile Application
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of JNJ-40346527 in Patients With Relapsed or Refractory Hodgkin Lymphoma
Status: COMPLETED
Conditions: Relapsed or Refractory Hodgkin Lymphoma
Interventions: DRUG: Phase 1, Cohort 1|DRUG: Phase 1, Cohort 2|DRUG: Phase 1, Cohort 3|DRUG: Phase 1, Cohort 4|DRUG: Phase 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Impacts of a Single Session of Robot Assisted Gait Training With a Trexo
Status: RECRUITING
Conditions: Physical Disability|CP (Cerebral Palsy)|Developmental Disability
Interventions: DEVICE: Robot Assisted Gait Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Hypoxia-driven Prostate Cancer Genomics (HYPROGEN)
Status: RECRUITING
Conditions: Prostate Cancer|Hypoxia
Interventions: DRUG: Optional non-IMP pimonidazole|DIAGNOSTIC_TEST: CT-guided Bone Biopsy|DIAGNOSTIC_TEST: TRUS-guided Targeted Transperineal Prostate Biopsy|PROCEDURE: Radical Prostatectomy|DIAGNOSTIC_TEST: Whole-body MRI|DIAGNOSTIC_TEST: Prostate MRI scans|OTHER: Baseline bloods - for germline testing|OTHER: Baseline bloods for CTCs and ct DNA taken at same time as baseline bloods in Arm 1|OTHER: Post-pimonidazole bloods for CTCs and ctDNA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pneumonia in the ImmunoCompromised - Use of the Karius Test for the Detection of Undiagnosed Pathogens
Status: COMPLETED
Conditions: Pneumonia, Bacterial|Pneumonia, Viral|Pneumonia Fungal|Pneumonia Cavitary|Immunocompromised Host
Interventions: DIAGNOSTIC_TEST: Karius Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p