pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Emptying Malaria Reservoirs to Accelerate Malaria Elimination in High Transmission Settings
Status: UNKNOWN
Conditions: Asymptomatic Malaria
Interventions: OTHER: Artemisia afra tea infusions|OTHER: Artemisia afra tea infusions|OTHER: Artemisia afra tea infusions|OTHER: Artemisia afra tea infusions|OTHER: Artemisia afra tea infusions|OTHER: Artemisia afra tea infusions|OTHER: Flavored placebo infusions|OTHER: Regular tea placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Pirfenidone Combined With Methylprednisolone Versus Methylprednisolone in the Treatment of CIP
Status: RECRUITING
Conditions: Pneumonitis|Malignant Tumor
Interventions: DRUG: Pirfenidone, methylprednisolone|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Auricular Vagus Nerve Stimulation and Electrotherapy Modalities in Patients With Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DEVICE: vagus stimülation device|DEVICE: Electrophysical agents|OTHER: home exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Multiple Micronutrient Fortified Biscuits and Deworming in Vietnamese School Children
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: worm treatment and multiple micronutrient fortified biscuits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bioequivalence Study of Two Formulations of Tablets Aceclofenac 100 mg in Healthy Volunteers Under Fasting Conditions
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Aceclofenac film-coated tablet 100 mg|DRUG: Airtal® film-coated tablet 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety & Efficacy Study of Study Drug (Eszopiclone) in Children and Adolescents With Attention-deficit/Hyperactivity Disorder - Associated Insomnia
Status: COMPLETED
Conditions: Insomnia|Attention Deficit Hyperactivity Disorder
Interventions: DRUG: eszopiclone|DRUG: eszopiclone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Canine Occlusal Relationship Changes After Full Mouth Rehabilitation Under General Anesthesia
Status: COMPLETED
Conditions: General Anesthesia
Interventions: DEVICE: Digital caliper (Shenzhen Jiabaili Electronic Commerce Co., Ltd)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study of Oral TLR8 Agonist Selgantolimod on HBsAg in Participants With Both Chronic Hepatitis B and HIV
Status: RECRUITING
Conditions: Hepatitis B|HIV Infections
Interventions: DRUG: Selgantolimod|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Safety, Tolerability, Pharmacokinetics, And Food Effect Of Single Doses Of GSK945237 In Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects|Infections, Bacterial
Interventions: DRUG: GSK945237|DRUG: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Pharmacokinetics of Irbesartan/Amlodipine FDC and Co-administration of Irbesartan and Amlodipine in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Irbesartan/Amlodipine FDC|DRUG: Irbesartan|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy, Safety and Tolerability of DNK333 (25 mg Bid) in Women With Diarrhea-predominant Irritable Bowel Syndrome (IBS-D)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Diarrhea (IBS-D)
Interventions: DRUG: DNK333|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of Task-Oriented Station Training on Cognitive Levels and Hand Functions in Geriatric Residents of Nursing Homes
Status: COMPLETED
Conditions: Cognitive Decline|Motor Function Disorders|Geriatric Health
Interventions: BEHAVIORAL: Face-To-Face Task-orianted Training|BEHAVIORAL: Tele-Rehabilitation Task-orianted Training|BEHAVIORAL: Home-based Task-orianted Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Capecitabine + Bevacizumab in Patients With Recurrent Glioblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: Capecitabine|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NeuroCovid Rehab and Recovery Related to COVID-19 Diagnosis
Status: COMPLETED
Conditions: Coronavirus|Covid19
Interventions: DEVICE: Soterix taVNS model 0125-LTE Stimulator - Active-Active Group|DEVICE: Soterix taVNS model 0125-LTE Stimulator - Sham-Active Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyoscine Butyl Bromide for Management of Prolonged Labor
Status: UNKNOWN
Conditions: Prolonged Labor
Interventions: DRUG: Hyoscine butyl bromide|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Accuracy of Dental Implant Placement Using Robotic System-assisted Surgery and Freehand Surgery
Status: RECRUITING
Conditions: Dental Implant
Interventions: PROCEDURE: dental implant robot|PROCEDURE: Freehand surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open, Prosp, Rand. Invest. Evaluating Pain With Mepitel One vs.Bridal Veil and Staples on Split Thickness Skin Grafts
Status: COMPLETED
Conditions: Deep Partial Thickness Burn|Full Thickness Burns
Interventions: DEVICE: Mepitel One
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Reverse Remodeling and PVI Versus CFAE and/or Linear Lesions and PVI for Persistent AF
Status: WITHDRAWN
Conditions: Persistent Atrial Fibrillation
Interventions: PROCEDURE: Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase I Vorinostat Concurrent With Stereotactic Radiosurgery (SRS) in Brain Metastases From Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Brain Cancer|Neoplasm Metastasis|Lung Cancer|Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Vorinostat|PROCEDURE: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib and Everolimus in Renal Cell Carcinoma (RCC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Lenvatinib|DRUG: Everolimus|PROCEDURE: Partial or Radical Cytoreductive Nephrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Intra Articular Injection of Catholic MASTER Cell (Bone Marrow Derived Mesenchymal Stem Cell) in Knee Osteoarthritis
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: BIOLOGICAL: Catholic MASTER cell|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Inhaled Oxytocin and HPA Axis Reactivity
Status: COMPLETED
Conditions: Depression, Postpartum|Anxiety Disorders|Stress, Psychological
Interventions: DRUG: Intranasal Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Chronic Circadian Disruption vs. Chronic Sleep Restriction on Metabolism
Status: COMPLETED
Conditions: Aging|Sleep Restriction|Circadian Disruption
Interventions: BEHAVIORAL: Circadian Disruption|BEHAVIORAL: Sleep Restriction|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Virtual Reality Training for Laparoscopic Cholecystectomy
Status: RECRUITING
Conditions: Virtual Reality|Gallbladder|Bile Duct Injury|Medical Education|Laparoscopy
Interventions: PROCEDURE: Virtual Reality training|PROCEDURE: Conventional training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Visualization of Topical Zoryve vs. Vehicle Using Line Field Optical Coherence Tomography in Healthy Skin
Status: RECRUITING
Conditions: Healthy Skin
Interventions: DRUG: Roflumilast|OTHER: Vehicle (Roflumilast 0.3% vehicle cream)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Open-label Vitamin D Trial for Patients With Cystic Fibrosis and Allergic Bronchopulmonary Aspergillosis
Status: COMPLETED
Conditions: Cystic Fibrosis|Allergic Bronchopulmonary Aspergillosis
Interventions: DIETARY_SUPPLEMENT: cholecalciferol (Vitamin D3)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of IMC-A12 in Combination With Sorafenib in Participants With Advanced Cancer of the Liver
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: IMC-A12 (cixutumumab) - 10 milligrams/kilogram (mg/kg)|BIOLOGICAL: IMC-A12 (cixutumumab) - 20 mg/kg|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Two Methods of Pancreatic Transection in Distal Pancreatectomy
Status: UNKNOWN
Conditions: Pancreatic Fistula|Distal Pancreatectomy
Interventions: DEVICE: Stapler|DEVICE: ultrasonic shears
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Aprepitant in the Prevention of Delayed Emesis Induced by Cyclophosphamide Plus Anthracyclines in Breast Cancer Patients
Status: TERMINATED
Conditions: Emesis
Interventions: DRUG: Aprepitant|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Success Rate of Immediately Loaded Implants With Platform Switched Design Placed in Anterior Part of Mandible and Restored With Fixed Prostheses
Status: COMPLETED
Conditions: Edentulism
Interventions: DEVICE: Ankylos Implants|DEVICE: Biomet 3i Prevail Implants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Healthy Moms-Healthy Kids: Reducing Maternal Depression for Better Outcomes in Head Start Children
Status: COMPLETED
Conditions: Maternal Depression|Parenting Behavior|Health|Interpersonal Relationships|Goal Directed Behavior|Child Behavior|Child School Readiness
Interventions: BEHAVIORAL: Interpersonal Psychotherapy for Depression -Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Stoppage Versus Continuation of Antimicrobial Therapy in Low Risk Pediatric Cancer Patients With Febrile Neutropenia, Before Recovery of Counts: -DALFEN Study
Status: TERMINATED
Conditions: Neutropenia, Febrile|Pediatric Cancer
Interventions: OTHER: stoppage of antibiotics|OTHER: amoxycillin/clavulanic acid|OTHER: levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Folic Acid Supplement Versus Placebo for Treating Mucositis Adverse Events in Metastatic Renal Cell Carcinoma Patients Receiving Targeted Therapy
Status: UNKNOWN
Conditions: Mucositis
Interventions: DRUG: Folic Acid|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab-Epacadostat Combination to Treat Muscle-invasive Bladder UrotheLIAl canceR: PECULIAR Study
Status: WITHDRAWN
Conditions: Muscle-invasive Bladder Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Epacadostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Yoga Therapy on Post-operative Side-effects Among Women With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Yoga Therapy|Shoulder Joint Motion|Scar Contracture
Interventions: BEHAVIORAL: Yoga therapy|BEHAVIORAL: Active control group|BEHAVIORAL: Passive control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HIV Risk Reduction in Subutex Injectors in Tbilisi
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: methadone|DRUG: buprenorphine-naloxone (Suboxone) for 12 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Tislelizumab Combined With TACE and Lenvatinib in the Neoadjuvant Treatment of Resectable HCC
Status: RECRUITING
Conditions: Hepatocellular Carcinoma Resectable
Interventions: COMBINATION_PRODUCT: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sirolimus (Rapamune ) for Relapse Prevention in People With Severe Aplastic Anemia Responsive to Immunosuppressive Therapy
Status: RECRUITING
Conditions: Severe Aplastic Anemia
Interventions: DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Effectiveness of Different Dose Levels of 1263W94 in the Treatment of Cytomegalovirus (CMV) of the Eyes in HIV-Infected Patients
Status: COMPLETED
Conditions: Cytomegalovirus Infections|HIV Infections
Interventions: DRUG: Maribavir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: A Safety and Effectiveness Study of Acetaminophen (4000 mg/Day) and Naproxen (750 mg/Day) in the Treatment of Osteoarthritis of the Hip or Knee
Status: COMPLETED
Conditions: Osteoarthritis, Hip|Osteoarthritis, Knee
Interventions: DRUG: acetaminophen|DRUG: naproxen|DRUG: acetaminophen|DRUG: naproxen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Antibiotic Therapy is Not Necessary to Implant Totally Implantable Venous Access Devices: Randomized Prospective Study
Status: COMPLETED
Conditions: Infections
Interventions: DEVICE: PORT-A-CATH (Smiths Medical Inc., MN)|DRUG: Amoxicillin and clavulanic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Acupressure on Reducing Pain and Improving Gastrointestinal Function After Laparoscopic Surgery
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: BEHAVIORAL: acupressure|BEHAVIORAL: sham acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of ABT-199 (GDC-0199) in Combination With Azacitidine or Decitabine (Chemo Combo) in Subjects With Acute Myelogenous Leukemia (AML)
Status: TERMINATED
Conditions: Acute Myelogenous Leukemia|Myelogenous Leukemia|Treatment Naive AML
Interventions: DRUG: Posaconazole|DRUG: ABT-199|DRUG: Decitabine|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adapted Physical Activity (APA) in a Breast Cancer Population.
Status: UNKNOWN
Conditions: Breast Neoplasms|Exercise|Exercise Therapy|Insulin Resistance|Oxidative Stress|Microcirculation|Quality of Life|Atherosclerosis
Interventions: OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Anatomy Scan for Evaluation of Obese Pregnant Women (EASE-O)
Status: COMPLETED
Conditions: Obesity
Interventions: DIAGNOSTIC_TEST: Group 1 (First trimester ultrasound)|DIAGNOSTIC_TEST: Group 2 (Second trimester anatomy ultrasound)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the NOVATECH ® LUCIOLA TM EB Fiducial Marker During Radiotherapy Sessions in Lung Cancer Patients
Status: RECRUITING
Conditions: Lung Cancer
Interventions: DEVICE: NOVATECH® LUCIOLA™ EB - (Fiducial Marker)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Food is Medicine vs Lifestyle Medicine For Cardiovascular Kidney Metabolic (CKM) Syndrome
Status: RECRUITING
Conditions: Diabetes Mellitus|Metabolic Syndrome|Obesity|Hypertension,Essential|Hyperlipidemias|Cardiovascular Diseases|Kidney Disease, Chronic
Interventions: BEHAVIORAL: Lifestyle Medicine Program|BEHAVIORAL: Medically Tailored Groceries
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calcitonin for Treating X-linked Hypophosphatemia
Status: COMPLETED
Conditions: Hypophosphatemic Rickets, X Linked Dominant
Interventions: DRUG: nasal salmon calcitonin|DRUG: Saline Nasal Spray Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Rehabilitation in Operation for LUng CAncer (PROLUCA)
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: BEHAVIORAL: Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Longitudinal Energy Expenditure and Metabolic Effects in Patients With COVID-19 (LEEP-COVID)
Status: COMPLETED
Conditions: COVID-19
Interventions: DEVICE: Q-NRG Metobolic Cart Device|DEVICE: MuscleSound Ultrasound|DEVICE: Multifrequency Bioimpedance Spectroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hormonal Status and Quality of Life in Female Postmenopausal Patients With Burning Mouth Syndrome
Status: COMPLETED
Conditions: Burning Mouth Syndrome|Progesterone|Dehydroepiandrosterone|Quality of Life|Hormone Disturbance|17β-Estradiol
Interventions: DIAGNOSTIC_TEST: unstimulated saliva sample for hormone analysis|OTHER: quality of life questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cetuximab and Pembrolizumab in Treating Patients With Colorectal Cancer That is Metastatic or Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Recurrent Colorectal Carcinoma|Stage IVA Colorectal Cancer|Stage IVB Colorectal Cancer
Interventions: BIOLOGICAL: Cetuximab|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Extended Operations And Pelvic Muscle Training In The Management Of Apical Support Loss Study
Status: COMPLETED
Conditions: Pelvic Organ Prolapse
Interventions: BEHAVIORAL: Enrollment video|PROCEDURE: SSLF|PROCEDURE: ULS|BEHAVIORAL: PMT|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Outcomes of Low-Impact Exercise Program for People With Ankle, Knee, and/or Hip Pain
Status: RECRUITING
Conditions: Osteoarthritis|Osteoarthritis, Knee|Osteoarthritis, Hip|Osteoarthritis Ankle
Interventions: OTHER: Group Physical Therapy Classes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of Botulinum Toxin Injection in Rectus Femoris and Triceps on the Length and the Strength During Locomotion in Chronic Hemiparetic Patients
Status: COMPLETED
Conditions: COMPARISON BETWEEN GROUP TREATED WITH BOTULINUM TOXIN AND PLACEBO
Interventions: DRUG: botulinum toxin type A|DRUG: injection of NaCl 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Continuation Treatment Study With Levodopa-Carbidopa Intestinal Gel in Advanced Parkinson's Disease
Status: COMPLETED
Conditions: Advanced Parkinson's Disease
Interventions: DRUG: Levodopa-Carbidopa Intestinal Gel (LCIG)|DEVICE: CADD-Legacy® 1400 ambulatory infusion pump|DEVICE: Percutaneous Endoscopic Gastrostomy with jejunal extension tube (PEG-J)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of 6-month of Treatment With TRPV1 and TRPA1 Agonists in Older Patients With OD
Status: NOT_YET_RECRUITING
Conditions: Oropharyngeal Dysphagia|Swallowing Disorder
Interventions: DIETARY_SUPPLEMENT: Capsaicin|DIETARY_SUPPLEMENT: Piperine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Safety of the Transplantation of Human Glial Restricted Progenitor Cells Into Subjects With Transverse Myelitis
Status: RECRUITING
Conditions: Transverse Myelitis
Interventions: BIOLOGICAL: Q-Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Methadone Dose Taken Using Electrochemistry
Status: ENROLLING_BY_INVITATION
Conditions: Methadone Toxicity|Methadone Overdose|Pain, Chronic|Drug Metabolism, Poor, CYP2D6-Related|Metabolism Medication Toxicity
Interventions: DEVICE: ISF extraction device 1|DIAGNOSTIC_TEST: Measurement of Methadone in the Interstitial Fluid (ISF) before and after prescribed dose taken ex vivo|DEVICE: Measurement of Methadone in the Interstitial Fluid before and after prescribed dose taken in vivo|DRUG: Measurement of Methadone in ISF before and after taking prescribed dose|DEVICE: ISF Extraction Device 2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment Options for Protease Inhibitor-exposed Children
Status: COMPLETED
Conditions: HIV/AIDS|HIV Infections
Interventions: DRUG: Efavirenz (EFV)|DRUG: Lopinavir/ritonavir (LPV/r)|DRUG: Stavudine (D4T)|DRUG: Abacavir (ABC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early NMES and Mirror Therapy Interventions During Immobilization of Distal Radius Fracture
Status: RECRUITING
Conditions: Distal Radius Fracture
Interventions: OTHER: Mirror Therapy|OTHER: Neuromuscular Stimulation (NMES)|OTHER: Mirror Therapy + NMES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety & Efficacy of Zirconium Silicate Dosed for 28 Days in Hyperkalemia.
Status: COMPLETED
Conditions: Hyperkalemia
Interventions: DRUG: Sodium zirconium cyclosilicate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chemotherapy in Treating Young Patients With Recurrent or Refractory Meningeal Leukemia, Lymphoma, or Solid Tumors
Status: UNKNOWN
Conditions: Brain and Central Nervous System Tumors|Leukemia|Lymphoma|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: liposomal cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: SCION: SABR and Checkpoint Inhibition of NSCLC
Status: WITHDRAWN
Conditions: Non Small Cell Lung Cancer|Carcinoma, Non-Small-Cell Lung|Non-small Cell Lung Cancer Stage I|Lung Cancer|Lung Cancer Stage I|Lung Adenocarcinoma, Stage I|Lung Squamous Cell Carcinoma Stage I
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Natural History and Disease Progression Biomarkers of Multiple System Atrophy
Status: COMPLETED
Conditions: Multiple System Atrophy
Interventions: DIAGNOSTIC_TEST: MRI acquisition|DIAGNOSTIC_TEST: DAT-SPECT|DIAGNOSTIC_TEST: blood sample, cerebrospinal fluid (optional)|BEHAVIORAL: Evaluations about motor abilities, depression, cognition and lifestyle|BEHAVIORAL: Evaluation about depression cognition
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Efficacy of Chlorhexidine Gluconate Pre - Disinfection Scrubbing in Preventing Surgical Site Infections for Hepatectomy Patients
Status: COMPLETED
Conditions: Liver Tumors
Interventions: DRUG: Chlorhexidine gluconate|DRUG: 0.9% Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of EP262 in Subjects With Chronic Spontaneous Urticaria
Status: RECRUITING
Conditions: Chronic Spontaneous Urticaria
Interventions: DRUG: Oral EP262|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interventions for Depressed Low Income Mothers and Their Infants
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Maternal interpersonal psychotherapy (IP)|BEHAVIORAL: Infant-parent psychotherapy|BEHAVIORAL: Informational meetings plus treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Artificial Intelligence Aid Systems and Endocuff in Colorectal Adenoma Detection
Status: UNKNOWN
Conditions: Adenoma Detection Rate
Interventions: DEVICE: Computed adenoma detection system (CADe) plus endocuff|DEVICE: Endocuff
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Preventive Approach to Congenital Heart Block With Hydroxychloroquine
Status: COMPLETED
Conditions: Congenital Heart Block|Neonatal Lupus|Autoantibody-Associated Heart Block
Interventions: DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Depressed Mood Improvement Through Nicotine Dosing 3
Status: RECRUITING
Conditions: Depressive Disorder
Interventions: DRUG: Transdermal Nicotine Patch|DRUG: Transdermal Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Self-efficacy, Planning, and Self-efficacy+Planning Interventions on Body Fat Among Adolescents
Status: COMPLETED
Conditions: Adolescent Behavior
Interventions: BEHAVIORAL: Self-Efficacy|BEHAVIORAL: Planning|BEHAVIORAL: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Controlled Hypotension in Rhinoplasty and Septoplasty: Incidence of Cognitive Dysfunction and Delirium
Status: COMPLETED
Conditions: Hypotension During Surgery
Interventions: OTHER: Group Low|OTHER: Group Middle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Free-residue Nutrients for the Bowel Preparation of Colon Capsule Endoscopy
Status: UNKNOWN
Conditions: Colorectal Polyps
Interventions: DRUG: Free-residue nutrients|DRUG: Low fiber diet|PROCEDURE: Colon capsule endoscopy|DRUG: 2L PEG|DRUG: 4L PEG|DRUG: PEG|DRUG: Mosapride citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Obinutuzumab, Ibrutinib, and Venetoclax for the Treatment of Previously Untreated Stage II-IV Follicular Lymphoma
Status: RECRUITING
Conditions: Ann Arbor Stage II Follicular Lymphoma|Ann Arbor Stage III Follicular Lymphoma|Ann Arbor Stage IV Follicular Lymphoma|Grade 1 Follicular Lymphoma|Grade 2 Follicular Lymphoma|Grade 3a Follicular Lymphoma
Interventions: DRUG: Ibrutinib|BIOLOGICAL: Obinutuzumab|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest of a Skin Transilluminator (Such as the VeinViewer®Vision Device) for Peripheral Venous Catheter Placement in the Obese Patient
Status: UNKNOWN
Conditions: General Surgery
Interventions: DEVICE: skin transilluminator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Immersion in Virtual Reality on Upper Limb Functionality in Subjects With Parkinson's Disease: Randomized Clinical Trial
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: Leap Motion Controller on flat display|DEVICE: Leap Motion Controller in Head-Mounted Display
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Device Settings for Airway Clearance Using The Monarch Airway Clearance System
Status: UNKNOWN
Conditions: Cystic Fibrosis
Interventions: DEVICE: Monarch Airway Clearance System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Implementation Science and Impact Evaluation of PfR Programme: A Hybrid cRCT Design
Status: COMPLETED
Conditions: Parenting|Gender-based Violence|Child Maltreatment|IPV
Interventions: BEHAVIORAL: Parenting for Respectability
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Testosterone Replacement on Exercise Capacity in Hypogonadal Men After a Recent Myocardial Infarction
Status: WITHDRAWN
Conditions: Hypogonadism|Acute Myocardial Infarction: Rehabilitation Phase
Interventions: DRUG: Testosterone|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective, Randomized, Multicenter, Control Study to Assess the Efficacy and Safety of Tacrolimus in Induction and Maintenance Phase Treatment in Lupus Nephritis
Status: COMPLETED
Conditions: Kidney Diseases|Lupus Nephritis|Tacrolimus|Induction Phase|Maintenance Phase
Interventions: DRUG: tacrolimus (FK506)|DRUG: cyclophosphamide or azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Increasing Access to Multiple Micronutrient Supplementation - A Pilot Intervention at up to 15 Clinics in Botswana
Status: ENROLLING_BY_INVITATION
Conditions: Pregnancy Related
Interventions: DIETARY_SUPPLEMENT: Multiple Micronutrient Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Tandem Auto Transplantation in Myeloma Patients With <12 Months of Prior Treatment
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Dexamethasone|PROCEDURE: Tandem autologous stem cell transplant|DRUG: Cisplatin|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Etoposide|DRUG: Bortezomib|DRUG: Thalidomide|DRUG: Melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Testing of Decision Support for Patients Who Are Candidates for an Implantable Defibrillator
Status: COMPLETED
Conditions: Cardiovascular Disease|Sudden Cardiac Death
Interventions: BEHAVIORAL: Patient Decision Aid for an ICD (primary prevention, non-CRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: TMC435-TiDP16-C123 - A Study in Healthy Volunteers Investigating the Pharmacokinetic Interaction Between TMC435 and the Antiretroviral Agents Efavirenz and Raltegravir
Status: COMPLETED
Conditions: Hepatitis C Virus
Interventions: DRUG: raltegravir|DRUG: TMC435 + raltegravir|DRUG: TMC435|DRUG: TMC435 + efavirenz|DRUG: TMC435|DRUG: efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Spinal Cord Stimulation in Children With Incomplete Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: OTHER: Gait training with/without TSCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Versus Combined Ultrasound and Fluoroscopy-guided Cervical Selective Nerve Root Block for Lower Cervical Radiculopathy: Non-inferiority Randomized Controlled Study
Status: UNKNOWN
Conditions: Cervical Pain
Interventions: DEVICE: ultrasound cervical selective nerve root block|DEVICE: ultrasound and fluoroscopy-guided cervical selective nerve root block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Home vs. Office Foley Catheter Removal in Women With Voiding Difficulty Following Pelvic Reconstructive Surgery
Status: COMPLETED
Conditions: Voiding Disorders
Interventions: PROCEDURE: Foley catheter removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study to Evaluate Antibody and Cell Mediated Immunity of A/H1N1 Influenza Vaccine in Healthy Subjects
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: egg-derived A/H1N1 pandemic influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: New Combination Regimen of L-asparaginase, Dexamethasone, Ifosfamide, Cisplatin and Etoposide in NK/T-Cell Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: DRUG: L-asp, DXM, IFO, VP-16, DDP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Castration-resistant Prostate Cancer and Intra-prostatic Hormonal Status
Status: WITHDRAWN
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: intra-prostatic concentration of sexual steroids|PROCEDURE: Trans-rectal biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A rTMS and Virtual Reality Based Cognitive Rehabilitation Program for MCI
Status: NOT_YET_RECRUITING
Conditions: Mild Cognitive Impairment|Caregiver Burden|Mental Health Issue|ADL|Quality of Life
Interventions: DEVICE: rTMS|DEVICE: rTMS+iVCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Aquaretic Tolvaptan on Nitric Oxide System. A Dose-response Study (DOVA)
Status: COMPLETED
Conditions: Nephropathy
Interventions: DRUG: 15 mg tolvaptan|DRUG: 30 mg tolvaptan|DRUG: 45 mg tolvaptan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Discontinuation of Trimethoprim-sulfamethoxazole Prophylaxis in Adults on Antiretroviral Therapy in Kenya
Status: COMPLETED
Conditions: HIV Infections|Acquired Immunodeficiency Syndrome|Disease Progression|Immune System Diseases|Malaria|Parasitic Diseases|Pneumonia|Diarrhea|Infectious Disorder of Immune System
Interventions: OTHER: Discontinue TMP/SMZ prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare the Pharmacokinetic of K-877 Controlled Release (CR) and Immediate Release (IR) Tablets in Healthy Adults.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: K-877 CR Tablet A|DRUG: K-877 CR Tablet B|DRUG: K-877 CR Tablet E|DRUG: K-877 IR Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase 3 Study of Bavituximab Plus Docetaxel Versus Docetaxel Alone in Patients With Late-stage Non-squamous Non-small-cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small-Cell Lung Cancer Stage IIIB|Non-Small-Cell Lung Cancer Stage IV|Non-Small-Cell Lung Cancer Metastatic|Carcinoma, Non-Small-Cell Lung|Non-Small Cell Lung Cancer|Non-Small-Cell Lung Carcinoma|Nonsmall Cell Lung Cancer
Interventions: BIOLOGICAL: bavituximab|DRUG: Docetaxel|OTHER: Placebo (for bavituximab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Two Dual Active Ingredient Long Lasting Insecticidal Nets for Control of Malaria Transmitted by Pyrethroid Resistant Vectors in Benin
Status: UNKNOWN
Conditions: Malaria|Anemia
Interventions: OTHER: Bed nets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Stepping Into Survivorship: Harnessing Behavioral Economics to Improve Quality of Life in Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: OTHER: Fitness Tracker|OTHER: Social Incentive (Way to Health)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 2 Study to Evaluate Axatilimab for Hospitalized Participants With Respiratory Involvement Secondary to COVID-19
Status: TERMINATED
Conditions: Coronavirus|COVID|ARDS|Cytokine Storm|Cytokine Release Syndrome
Interventions: DRUG: SNDX-6352|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: T Cell Transfer With or Without Dendritic Cell Vaccination in Patients With Melanoma
Status: RECRUITING
Conditions: Melanoma
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|BIOLOGICAL: T cells|BIOLOGICAL: Interleukin-2|BIOLOGICAL: Dendritic cell vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simvastatin for the Treatment of Chronic Hepatitis B
Status: COMPLETED
Conditions: Hepatitis B
Interventions: DRUG: Simvastatin|DRUG: Tenofovir|DRUG: Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Feasibility Study of Re-treating Patients With Severe Emphysema With the RePneu LVRC System.
Status: COMPLETED
Conditions: COPD|Emphysema
Interventions: DEVICE: Bronchoscopic lung volume reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Electroacupuncture (EA) for Women With Pure Stress Urinary Incontinence (SUI)
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: OTHER: EA|OTHER: sham EA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Capsule Biopsy in Acellular Dermal Matrix-based Prosthetic Breast Reconstruction: a Prospective Pilot Study
Status: COMPLETED
Conditions: Breast Neoplasms|Mammaplasty|Acellular Dermis
Interventions: PROCEDURE: breast capsule biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: A Double-Blind Trial of Adjunctive Valacyclovir to Improve Cognition in Early Phase Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Valacyclovir HCI 500 mg tablets|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Contact to Dogs During Stressful Situations
Status: COMPLETED
Conditions: Physiological Stress Responses to Standardises Stress Situations|Psychological Responses to Standardised Stress Situations|Behavioural Responses to Standardised Stress Situations
Interventions: OTHER: Dog|OTHER: No Dog
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Robotic Compared to Fixed Gantry Radiosurgery for Brain Metastases
Status: UNKNOWN
Conditions: Metastatic Malignant Neoplasm to the Adult Brain
Interventions: RADIATION: Fixed Gantry Radiosurgery|RADIATION: Robotic Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Vaccine Therapy in Preventing Cervical Cancer in Patients With Cervical Intraepithelial Neoplasia
Status: COMPLETED
Conditions: Cervical Cancer|Precancerous Condition
Interventions: BIOLOGICAL: pNGVL4a-Sig/E7(detox)/HSP70 DNA vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of MK-0822 in Postmenopausal Women With Osteoporosis to Assess Fracture Risk (MK-0822-018)
Status: TERMINATED
Conditions: Postmenopausal Osteoporosis
Interventions: DRUG: Odanacatib|DRUG: Placebo for Odanacatib|DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Calcium carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Second-Line Therapy Study For Potentially Platinum-Sensitive Relapsed Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Neoplasms, Ovarian
Interventions: DRUG: topotecan|DRUG: CARBOPLATIN
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Endogenous E2 on SSI and GH Rebound
Status: COMPLETED
Conditions: Normal Healthy Volunteers
Interventions: DRUG: Fulvestrant|DRUG: Anastrozole|DRUG: Placebo|DRUG: Somatostatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: XC8 in the Treatment of Patients With Acute Respiratory Viral Infection
Status: COMPLETED
Conditions: Influenza|Acute Respiratory Infection
Interventions: DRUG: XC8 20 mg|DRUG: XC8 100 mg|DRUG: XC8 200 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the SING IMT in an Israeli Cohort
Status: NOT_YET_RECRUITING
Conditions: Age-Related Macular Degeneration|Geographic Atrophy
Interventions: DEVICE: smaller incision, new generation implantable miniature telescope (SING-IMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Diabetic Peripheral Neuropathic Pain
Status: UNKNOWN
Conditions: Diabetic Peripheral Neuropathic Pain
Interventions: DRUG: HSK16149 20mg BID|DRUG: HSK16149 40mg BID|DRUG: HSK16149 60mg BID|DRUG: HSK16149 80mg BID|DRUG: Pregabalin 150mg BID|DRUG: Placebo BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Trial for a Right Ventricular Failure Platform Trial
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Hypertension|Right Ventricular Dysfunction|Right Heart Failure
Interventions: DRUG: Empagliflozin|DRUG: Ranolazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT