pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Preoperative Chest Physiotherapy on Lung Functions Among Open Heart Surgery Patients
Status: COMPLETED
Conditions: Open Heart Surgery Patients
Interventions: PROCEDURE: preoperative chest physiotherapy|PROCEDURE: postoperative chest physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Disposable Versus Disposable Nephroscope During PCNLs: a Feasibility RCT
Status: NOT_YET_RECRUITING
Conditions: Stone, Kidney
Interventions: PROCEDURE: Disposable mini-PCNL|PROCEDURE: Re-usable mini-PCNL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: L-carnosine Prophylactic Effect on Oxaliplatin Induced Peripheral Neuropathy in GIT Cancer Patients
Status: COMPLETED
Conditions: Peripheral Neuropathy|Cancer
Interventions: DRUG: L-CARNOSINE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Ensartinib as Neoadjuvant Therapy for Patients With ALK Positive Resectable Non-Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Ensartinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Robotic Gait Training and Physical Therapy for Children and Youth With Cerebral Palsy
Status: RECRUITING
Conditions: Cerebral Palsy
Interventions: PROCEDURE: Lokomat (LOK)|PROCEDURE: Gait focused physical therapy (fPT)|PROCEDURE: LOK + fPT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bipolar Transcranial Alternating Current Stimulation (tACS)
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DEVICE: tACS brain stimulation treatment|DEVICE: Sham stimulation treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Aromatherapy on Sleep, Anxiety and Vital Signs in Those With Essential Hypertension (Hypertension)
Status: ENROLLING_BY_INVITATION
Conditions: Hypertension|Aromatherapy
Interventions: OTHER: intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Symptomatic Treatment of Vascular Cognitive Impairment
Status: UNKNOWN
Conditions: Mild Cognitive Impairment (Vascular)|Mild Cognitive Disorder (Vascular)|Vascular Dementia
Interventions: DRUG: Galantamine|DRUG: Methylphenidate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Mesenchymal Stem Cells in Rotator Cuff Repair
Status: SUSPENDED
Conditions: Rotator Cuff Tear|Tendon Injuries|Mesenchymal Stem Cell
Interventions: BIOLOGICAL: Mesenchymal stem cell|PROCEDURE: Rotator cuff repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Nutritional Support in Esophagectomy or Pancreaticoduodenectomy
Status: COMPLETED
Conditions: Esophagectomy|Pancreaticoduodenectomy
Interventions: DIETARY_SUPPLEMENT: Impact Advanced Recovery|DIETARY_SUPPLEMENT: No supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Long Term Study of Valsartan and Amlodipine in Patients With Essential Hypertension (Extension to Study CVAA489A1301)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Valsartan + Amlodipine besilate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radioaerossol Pulmonary Deposition Using Mesh in Normal Subjects
Status: COMPLETED
Conditions: Normal Subjects
Interventions: OTHER: Mesh nebulizer|OTHER: Jet nebulizer|OTHER: Noninvasive ventilation-NIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Pharmacodynamics (PK/PD) of CEP-26401 in Healthy Subjects
Status: COMPLETED
Conditions: Cognitive Impairment
Interventions: DRUG: CEP-26401|DRUG: donepezil hydrochloride|DRUG: modafinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock
Status: TERMINATED
Conditions: Sepsis|Septic Shock|Critical Illness|Fluid Overload
Interventions: DRUG: Vitamin C|DRUG: Hydrocortisone|DRUG: Thiamine|DRUG: 0.9% Sodium Chloride Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Cannabidiol for Graft Versus Host Disease (GVHD) Prophylaxis in Allogeneic Stem Cell Transplantation
Status: UNKNOWN
Conditions: Graft Versus Host Disease
Interventions: DRUG: Oral Cannabidiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of an Intervention to Teach Zippering: A Two-Group Control Study
Status: COMPLETED
Conditions: Typical Preschoolers Who Can Not Zipper
Interventions: BEHAVIORAL: Standard zippering vest|BEHAVIORAL: Modified zippering vest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine and Compare Plasma and Intrapulmonary Concentrations of ETX2514 and Sulbactam in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ETX2514 and sulbactam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessment of Intraocular Pressure (IOP) Control in Subjects With Open-Angle Glaucoma or Ocular Hypertension Treated With Travoprost 0.004% (TRAVATAN® Z) or Bimatoprost 0.01% (LUMIGAN®)
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension|Open-Angle Glaucoma
Interventions: DRUG: Travoprost 0.004% ophthalmic solution|DRUG: Bimatoprost 0.01% ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ramucirumab Plus Pembrolizumab in Participants With Gastric or GEJ Adenocarcinoma, NSCLC, Transitional Cell Carcinoma of the Urothelium, or Biliary Tract Cancer
Status: COMPLETED
Conditions: Gastric Adenocarcinoma|Adenocarcinoma of the Gastroesophageal Junction|Non-small Cell Lung Cancer|Carcinoma, Transitional Cell|Biliary Tract Cancer
Interventions: DRUG: Ramucirumab|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of the Modified Story Memory Technique (mSMT)© to Aging
Status: COMPLETED
Conditions: Aging|Mild Cognitive Impairment
Interventions: BEHAVIORAL: Memory retraining exercises|BEHAVIORAL: Placebo control memory exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of IMC-002 in Subjects With Metastatic or Locally Advanced Solid Tumors and Relapsed or Refractory Lymphomas
Status: COMPLETED
Conditions: Solid Tumor|Lymphoma
Interventions: BIOLOGICAL: IMC-002
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Whole Versus Processed Orange Consumption on Satiety
Status: COMPLETED
Conditions: Satiety Response
Interventions: DIETARY_SUPPLEMENT: Processed orange juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dobutamine Echocardiography In Patients With Ischemic Heart Failure Evaluated for Revascularization
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Disease|Heart Failure|Heart Failure, Congestive|Heart Diseases
Interventions: PROCEDURE: Coronary Artery Bypass|DRUG: Modern medical management|DEVICE: Dobutamine echocardiography|DRUG: Optimal medical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Topical Silver Nanoparticles for Microbial Activity
Status: UNKNOWN
Conditions: Foot Infection Fungal|Infection, Bacterial
Interventions: DRUG: Silver nanoparticles|DRUG: Topical approved anti-microbial gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Anti PD-1 Neo-adjuvant Treatment for NSCLC
Status: COMPLETED
Conditions: Non Small Cell Lung Carcinoma|Stage I|Stage II
Interventions: DRUG: Pembrolizumab 200 mg IV single dose|DRUG: Pembrolizumab 200 mg IV twice interval 21 days|DRUG: Pembrolizumab 200 mg IV Twice interval 21d,surgery after 10d|DRUG: Pembrolizumab 100 mg I.V single dose|PROCEDURE: Surgical resection of tumor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Efficacy of Phenazopyridine Hydrochloride Tablets, USP 200 mg vs. Placebo
Status: COMPLETED
Conditions: Pain|Urinary Tract Infections
Interventions: DRUG: Phenazopyridine Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Genetic Substudy Associated With the Avastin (Bevacizumab) Study MO19390 in Patients With Advanced or Recurrent Non-Squamous Cell Lung Cancer.
Status: TERMINATED
Conditions: Non-Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: Standard chemotherapy|DRUG: bevacizumab [Avastin]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fish Oil for HIV-Related Inflamm-aging and Immune Senescence
Status: COMPLETED
Conditions: HIV Infection
Interventions: DIETARY_SUPPLEMENT: Fish oil that contains omega-3 fatty acids|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Levilactobacillus Brevis Oral Health
Status: COMPLETED
Conditions: Oral Health|Oral Disease
Interventions: DIETARY_SUPPLEMENT: Levilactobacillus brevis CNCM I-5566|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Of SU011248 In Combination With Docetaxel And Trastuzumab In Patients With Advanced Breast Cancer HER-2 Positive
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Herceptin|DRUG: Sunitinib|DRUG: Taxotere
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Immunogenicity Phase IB Study of CryJ2-DNA-Lysosomal Associated Membrane Protein (CryJ2 -DNA-LAMP) Plasmid Assessing the Long Term Safety of Previously Treated Subjects
Status: COMPLETED
Conditions: Allergic Rhinoconjunctivitis
Interventions: BIOLOGICAL: CryJ2-DNA-LAMP plasmid vaccine by intramuscular injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Opioid Use in Low Back Pain and Lumbar Orthosis Intervention
Status: UNKNOWN
Conditions: Chronic Lower Back Pain|Chronic Opioid Use
Interventions: DEVICE: In-elastic lumbar brace|DEVICE: Elastic abdominal binder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ferumoxytol Versus Oral Iron in the Treatment of Anemia in Non-Dialysis Dependent Chronic Kidney Disease Patients
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: ferumoxytol or oral iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IVF/ICSI Protocols in Poor Responders With Growth Hormone
Status: COMPLETED
Conditions: Female Infertility Due to Diminished Ovarian Reserve
Interventions: DRUG: Growth hormone (Norditropin, Novo nordisk)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictors Associated With Seeking Orthodontic Treatment, Compliance and Treatment Success
Status: COMPLETED
Conditions: Malocclusion, Angle Class II
Interventions: DEVICE: Twin Block|DEVICE: Sander bite jumping appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study Evaluating an Organ Preservation Strategy Using Immune Checkpoint Blockade for Participants With Primary Colorectal or Gastroesophageal Cancer
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer|Gastroesophageal Cancer
Interventions: DRUG: nivolumab|DRUG: ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tumor Lysate Pulsed-Dendritic Cell Vaccines After High-Dose Chemotherapy for Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin
Interventions: BIOLOGICAL: tumor-pulsed dendritic cells
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Artificial Intelligence-based ChatBot to Improve Women's Participation to Cervical Cancer Screening Programme
Status: NOT_YET_RECRUITING
Conditions: Cervical Cancer Screening|Cervical Cancer
Interventions: BEHAVIORAL: Decision aid tailored to women with lower educational attainment,accessible via artificial intelligence-based Chatbot platforms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: 18FDG PET for Early Identification of Tumor Exhaust for Immunotherapy in Patients With Locally Advanced or Metastatic Non-Small Cell Bronchopulmonary Carcinoma or Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Bronchopulmonary Carcinoma or Melanoma
Interventions: RADIATION: 18FDG PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Dose Finding Study to Assess Efficacy and Safety of IBI128 in Chinese Gout Subjects
Status: NOT_YET_RECRUITING
Conditions: Gout|Hyperuricemia
Interventions: DRUG: Febuxostat|DRUG: IBI128
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrical Stimulation Combined With Motor Training on EEG-EMG Coherence and Motor Function in Individuals With Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Electrical stimulation|OTHER: Sham electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Safety and Efficacy of PAC-14028 Cream in Skin Pruritus
Status: COMPLETED
Conditions: Skin Pruritus
Interventions: DRUG: PAC-14028 cream 0.1%|DRUG: PAC-14028 cream 0.3%|DRUG: PAC-14028 cream 1.0%|DRUG: PAC-14028 cream vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Remimazolam and Propofol Effect on Oxygen Reserve During Endoscopic Retrograde Cholangiopancreatography
Status: RECRUITING
Conditions: Hepatobiiliary Diseases Requiring Endoscopic Retrograde Cholangiopancreatography
Interventions: DRUG: Remimazolam besylate|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bone Marrow Transplantation Plus Biological Therapy in Treating Patients With Chronic Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: recombinant interferon alfa|BIOLOGICAL: sargramostim|PROCEDURE: autologous bone marrow transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Isometric Handgrip Training on Ambulatory Blood Pressure in Patients With Hypertension
Status: RECRUITING
Conditions: Hypertension
Interventions: BEHAVIORAL: Supervised Isometric Handgrip Training|BEHAVIORAL: Sham comparator - stretching and relaxation exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of JK08 in Patients With Unresectable Locally Advanced or Metastatic Cancer
Status: RECRUITING
Conditions: Cancer|Tumor, Solid|Advanced Solid Tumor|Metastatic Cancer|Melanoma|Colorectal Cancer|Non-small Cell Lung Cancer|Small-cell Lung Cancer|Urothelial Carcinoma|Squamous Cell Carcinoma of Head and Neck|Luminal Breast Cancer|Triple Negative Breast Cancer|Clear Cell Renal Cell Carcinoma|Papillary Renal Cell Carcinoma|Gastric Adenocarcinoma|GastroEsophageal Cancer|Squamous Cell Carcinoma Skin|Pancreatic Adenocarcinoma|Hepatocellular Carcinoma|Colorectal Adenocarcinoma|Epithelial Ovarian Cancer|Thyroid Cancer
Interventions: DRUG: JK08|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sotagliflozin on Cardiovascular Events in Participants With Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF Trial)
Status: TERMINATED
Conditions: Heart Failure|Type 2 Diabetes Mellitus
Interventions: DRUG: Sotagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I, Dose Escalation Study of BNC101 in Patients With Metastatic Colorectal Cancer.
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: BNC101 Solution for Infusion|DRUG: BNC101 in combination with FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Ipilimumab and Nivolumab for the Treatment of Rare Cancers
Status: COMPLETED
Conditions: Gastrointestinal Cancer|Neuroendocrine Tumours|Malignant Female Reproductive System Neoplasm
Interventions: DRUG: Ipilimumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of MGCD0103 Given Three-Times Weekly in Patients With Advanced Solid Tumors or Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Tumors|Non Hodgkin's Lymphoma
Interventions: DRUG: MGCD0103
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Intravesical BCG in Combination With ALT-803 in Patients With Non-Muscle Invasive Bladder Cancer
Status: RECRUITING
Conditions: Non-muscle Invasive Bladder Cancer
Interventions: BIOLOGICAL: BCG+N-803( 50mg BCG/ Instillation+ N-803( 400 μg/instillation). )|BIOLOGICAL: BCG( 50mg/Instillation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors
Status: TERMINATED
Conditions: Adult Central Nervous System Germ Cell Tumor|Adult Teratoma|Malignant Extragonadal Germ Cell Tumor|Malignant Extragonadal Non-Seminomatous Germ Cell Tumor|Extragonadal Seminoma|Recurrent Malignant Testicular Germ Cell Tumor|Recurrent Ovarian Germ Cell Tumor|Stage IV Extragonadal Non-Seminomatous Germ Cell Tumor|Stage IV Extragonadal Seminoma|Stage IV Ovarian Germ Cell Tumor
Interventions: DRUG: palifosfamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Convalescent Plasma Collection and Treatment in Pediatrics and Adults
Status: RECRUITING
Conditions: COVID19|Coronavirus Infection|Coronavirus|Virus Diseases|RNA Virus Infections
Interventions: BIOLOGICAL: Convalescent Plasma 1 Unit|BIOLOGICAL: Convalescent Plasma 2 Units|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Test Safety of Biodegradable and Permanent Limus-Eluting Stents Assessed by Optical Coherence Tomography
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DEVICE: Biodegradable polymer limus-eluting stents|DEVICE: Permanent polymer limus-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose of Sugammadex vs Neostigmine and Glycopyrrolate for the Reversal of Rocuronium
Status: COMPLETED
Conditions: Neuromuscular Blockade
Interventions: DRUG: Neostigmine and glycopyrrolate|DRUG: Sugammadex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alfapump Direct Sodium Removal (DSR) Feasibility Study
Status: COMPLETED
Conditions: Heart Failure|Congestive Heart Failure|Cardiorenal Syndrome|Volume Overload|Sodium Excess|Sodium Disorder
Interventions: DEVICE: alfapump DSR system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: APRICOT-3: Antithrombotics in the Prevention of Reocclusion In COronary Thrombolysis -3
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: PROCEDURE: Percutaneous coronary intervention (PCI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interferential Current And Trapezius Myofascial Trigger Points
Status: COMPLETED
Conditions: Upper Trapezius Trigger Points
Interventions: OTHER: Stander treatment|DEVICE: Interferential current with carrier frequency 2 KHz|DEVICE: Interferential current with carrier frequency 4 KHz|DEVICE: Interferential current with carrier frequency 8 KHz|DEVICE: placebo interferential current
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact on Opioid Use of Bundling Medication-assisted Treatment With mHealth
Status: COMPLETED
Conditions: Opioid Use Disorder
Interventions: BEHAVIORAL: MAT + A-CHESS|OTHER: MAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate Induction of HBV Virus Neutralizing Antibodies Using VVX001
Status: UNKNOWN
Conditions: Hepatitis B
Interventions: BIOLOGICAL: VVX001|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Manually Performed Limbal Relaxing Incisions vs Femtosecond Laser-guided Astigmatic Keratotomy
Status: COMPLETED
Conditions: Corneal Astigmatism
Interventions: PROCEDURE: limbal relaxing incisions|PROCEDURE: astigmatic keratotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biobehavioral Effects of Topiramate on Cannabis-Related Outcomes in Adolescents
Status: COMPLETED
Conditions: Cannabis Abuse|Cannabis Dependence
Interventions: DRUG: Topiramate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Niacin, N-3 Fatty Acids and Insulin Resistance
Status: COMPLETED
Conditions: Metabolic Syndrome|Hypertriglyceridemia
Interventions: DRUG: omega-3 acid ethyl esters|DRUG: extended release niacin|DRUG: placebo|DRUG: omega-3 acid ethyl esters|DRUG: combined treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Angiographic Embolization vs Non-embolization of Moderate/Poor Vascularized Vertebral Metastases on Intraoperative Bleeding During Surgery Decompression and Vertebral Stabilization.
Status: RECRUITING
Conditions: Spine Metastasis|Early Goal Directed Therapy|Embolization, Therapeutic|Blood Loss
Interventions: PROCEDURE: Embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Emotion Regulation Flexibility: Testing the Efficacy of an Emotion Regulation Program in College Students
Status: UNKNOWN
Conditions: Anxiety Depression|Emotion Regulation
Interventions: BEHAVIORAL: ART|BEHAVIORAL: Relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Ocrevus in Relapsing Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: Ocrelizumab|DRUG: Platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Longitudinal or Transverse Orientation of Ultrasound Probe in Minimally Invasive Venous Surgery.
Status: COMPLETED
Conditions: Varicose Veins|Endovenous Procedures|Venous Access
Interventions: DIAGNOSTIC_TEST: Longitudinal|DIAGNOSTIC_TEST: Transverse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Oral Nutritional Supplement (preOP Booster) in Visceral Surgery
Status: COMPLETED
Conditions: Enteral Nutrition (Food for Special Medical Purposes)
Interventions: DIETARY_SUPPLEMENT: preOP booster (oral nutritional supplement, food for special medical purposes)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CONVERGE CAP Study-For The Treatment Of Symptomatic Persistent or Long-standing Persistent AF
Status: WITHDRAWN
Conditions: Atrial Fibrillation
Interventions: DEVICE: Convergence Of Epicardial And Endocardial RF Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Corticospinal Activation for Improved Walking Function
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: OTHER: Motor Skill Training|DEVICE: Transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Positron Emission Tomography (PET) Approach to Measuring Myocardial Metabolism
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: thiapalmitate tracer|DRUG: Saline|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cadonilimab in Combination With Lenvatinib and Hepatic Arterial Infusion Chemotherapy (HAIC) for the Treatment of Unresectable Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Cadonilimab|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Effects of Anatabloc® Crème in Rosacea
Status: COMPLETED
Conditions: Rosacea
Interventions: OTHER: Anatabloc Cream|OTHER: Placebo Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity Study of the Influenza Vaccine in Adults
Status: COMPLETED
Conditions: Orthomyxoviridae Infections|Influenza
Interventions: BIOLOGICAL: Inactivated, split-virion influenza vaccine|BIOLOGICAL: Inactivated, split-virion, influenza virus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Efficacy and Safety of Combination Therapy and Monotherapy of Candesartan and Amlodipine for Dose-Finding in Patients With Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Candesartan Cilexetil 8mg|DRUG: Candesartan Cilexetil 16mg|DRUG: Amlodipine 5mg|DRUG: Amlodipine 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Tolerability, as Well as the Pharmacokinetic and Pharmacodynamic Profiles of Single and Multiple Doses of Eplontersen Administered Subcutaneously to Healthy Volunteers and Patients With Hereditary Transthyretin-Mediated Amyloidosis (hATTR ).
Status: COMPLETED
Conditions: Healthy Volunteers|hATTR Amyloidosis
Interventions: DRUG: ION-682884|DRUG: Placebo|DIETARY_SUPPLEMENT: Vitamin A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neural Mechanism of Cortisol Awakening Response Suppression Effect on Human High-order and Social Cognitions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Dexamethasone|DRUG: Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Yogurt With Polydextrose,L Acidophilus and B Lactis in Chronic Constipation
Status: COMPLETED
Conditions: Constipation
Interventions: DIETARY_SUPPLEMENT: yogurt containing: polydextrose L. acidophilus NCFM® B. lactis HN019
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sub-lobectomy for IDH Wild-type and TERT Promoter Mutant Glioblastoma
Status: NOT_YET_RECRUITING
Conditions: Glioma|Glioblastoma
Interventions: PROCEDURE: sub-lobectomy|PROCEDURE: imaging total resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Ventral Hernia Repair With Elastomeric Pain Pump
Status: COMPLETED
Conditions: Hernia, Ventral
Interventions: DRUG: bupivacaine|DEVICE: On-Q PainBuster pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Short-term Behavioral Effects of Cholesterol Therapy in Smith-Lemli-Opitz Syndrome
Status: COMPLETED
Conditions: Smith-Lemli-Opitz Syndrome
Interventions: DIETARY_SUPPLEMENT: Egg yolk preparation with cholesterol|DIETARY_SUPPLEMENT: Egg substitute, without cholesterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability, Safety and Pharmacokinetics of a Topical AB001 Patch in Healthy Subjects
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: DRUG: AB001|DRUG: oral capsule|DRUG: positive comparative patch|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Early Intensive ROsuvastatin Therapy in Patients With ST-segment Elevation Myocardial Infarction Undergoing PrimARY Percutaneous Coronary Intervention (the ROSEMARY Trial)
Status: COMPLETED
Conditions: ST-segment Elevation AMI
Interventions: DRUG: Early intensive rosuvastatin therapy (40 mg for 7days, starting in ER prior to primary PCI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Management of LDL-cholesterol With Inclisiran + Usual Care Compared to Usual Care Alone in Participants With a Recent Acute Coronary Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Inclisiran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Night Spectacle Correction Concerning an Improvement of Mesopic Vision Quality
Status: COMPLETED
Conditions: Myopia-Night Blindness
Interventions: DEVICE: Spectacle/Glasses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Air Polishing Effect on Biological, Clinical and Patient-reported Experience Among Epileptic and Non-epileptic Children
Status: COMPLETED
Conditions: Epilepsy|Gingivitis
Interventions: DEVICE: Air polishing with erythritol powder|DEVICE: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "Resilient Caregivers" - A Resilience-based Intervention for Distressed Partner Cancer Caregivers
Status: UNKNOWN
Conditions: Distress, Emotional
Interventions: BEHAVIORAL: "Resilient Caregivers"|OTHER: Care as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pharmacokinetics and Safety of A006 in Healthy Volunteers
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: A006 DPI|DRUG: A006 DPI|DRUG: Proventil® MDI|DRUG: Proventil® MDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Zhineng Qigong Intervention for Patients With Chronic Low Back Pain and/or Leg Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain|Chronic Sciatica|Lumbar Spinal Stenosis|Lumbar Disc Herniation|Lumbar Spondylolisthesis|Lumbago|Lumbar Disc Degeneration|Persistent Postoperative Pain
Interventions: OTHER: Zhineng Qigong intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Brolucizumab vs. Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Brolucizumab|DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of High Amplitude and Focused tACS on Entraining Physiological Tremor
Status: COMPLETED
Conditions: Tremor, Limb
Interventions: DEVICE: tACS at tremor frequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Single-center Clinical Study to Evaluate the Safety and Efficacy of Autologous Bone Marrow-derived DCs(CellgramDC-WT1) and Immune Checkpoint Inhibitors in Patients With Metastatic Pancreatic Cancer Who Have Failed First-line or More Standard Chemotherapy
Status: NOT_YET_RECRUITING
Conditions: Pancreas Cancer
Interventions: DRUG: dentritic cell infusion and immunecheckpoint inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Therapy Combined With Radical Surgery for the Treatment of Small Cell Lung Cancer (SCLC) in II and IIIA Stage
Status: UNKNOWN
Conditions: Small-cell Lung Cancer
Interventions: DRUG: neoadjuvant chemotherapy|PROCEDURE: radical surgery for stage II and IIIA small cell lung cancer (SCLC)|PROCEDURE: prophylactic cranial irradiation|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total-body PET/CT Imaging Using the uEXPLORER in Non-small Cell Lung Cancer Patients Treated by Induction Chemotherapy Plus Nivolumab and Definitive Concurrent Chemoradiotherapy
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DEVICE: Total body PET/CT (uExplorer)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Combination of Arimidex and Nolvadex in Adjuvant Therapy of Breast Carcinoma in Postmenopausal Women.
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Anastrozole|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nasogastric Tube Insertion Using Midazolam in the Emergency Department
Status: COMPLETED
Conditions: Intubation; Difficult
Interventions: DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Magnetic Seizure Therapy (MST) for the Treatment of Major Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: Magstim Theta|DEVICE: Thymatron System IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Double-Blind, Randomized, Placebo-Controlled, 12-Week, Dose-Range-Finding Trial of YKP10811 Capsules Administered Once Daily to Subjects With Chronic Idiopathic Constipation
Status: COMPLETED
Conditions: Chronic Idiopathic Constipation
Interventions: DRUG: YKP10811|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Safety, Tolerability and Pharmacokinetics of GRC 27864 in Healthy Subjects and Elderly Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GRC 27864|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Influence of Hydration and Functional Aerobic Capacity on the Nonlinear Dynamics of Heart Rate in Healthy Individuals
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: water|OTHER: aerobic activity
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluating Safety of Escalating Doses of Tilmanocept by IV Injection and SPECT Imaging in Subjects With and Without RA
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Tc99m-tilmanocept|PROCEDURE: SPECT Imaging (60 Minutes post-injection)|PROCEDURE: SPECT Imaging (180 Minutes post-injection)|PROCEDURE: Whole body planar SPECT imaging (15 Minutes post-injection)|PROCEDURE: Whole body planar SPECT imaging (60 Minutes post-injection)|PROCEDURE: Whole body planar SPECT imaging (180 Minutes post-injection)|PROCEDURE: Whole body planar SPECT imaging (18-20 Hours post-injection)|PROCEDURE: Blood Collection for PK Testing (15 Mins Before Injection)|PROCEDURE: Blood Collection for PK Testing (after injection)|PROCEDURE: Blood Collection for PK Testing (15 minutes post injection)|PROCEDURE: Blood Collection for PK Testing (60 minutes post injection)|PROCEDURE: Blood Collection for PK Testing (180 minutes post injection)|PROCEDURE: Blood Collection for PK Testing (18-20 hours post injection)|PROCEDURE: Planar Image with both Hands in Field of View
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Vitamin Therapy for Prevention of Stroke
Status: COMPLETED
Conditions: Stroke|Cerebral Infarction|Myocardial Infarction
Interventions: DRUG: pyridoxine|DRUG: cyanocobalamin|DRUG: folic acid multivitamin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Study of the Safety, Tolerability, Pharmacokinetics and Food Effect After Single and Multiple Ascending Oral Doses
Status: COMPLETED
Conditions: Autoimmune Diseases
Interventions: DRUG: AX-158
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Amino Acid Addition to a Drink on the Appearance of Ingested Water in Body Fluids
Status: COMPLETED
Conditions: Rate of Water Appearance/Delivery in the Blood Water Balance
Interventions: OTHER: Composition of Sports Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of HIV Protease Inhibitor Drugs on Glucose and Insulin Metabolism
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Atazanavir/Ritonavir/Lopinavir/ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeting Cellular Senescence With Senolytics to Improve Skeletal Health in Older Humans
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Dasatinib|DRUG: Quercetin|DRUG: Fisetin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: New Onset Type 1 Diabetes: Role of Exenatide
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Exenatide|DRUG: Rapid and long acting insulin|DRUG: long acting insulin + rapid acting + 1.25 mcg Exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of SMP on Renal Pelvic Pressure In Vivo
Status: UNKNOWN
Conditions: Renal Calculi
Interventions: PROCEDURE: Super-Mini Percutaneous Nephrolithotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Temozolomide Monotherapy or in Combination With Olaparib in Patients With Triple Negative Breast Cancer (TNBC)
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer Triple Negative
Interventions: DRUG: Temozolomide|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Covid-19 HEalth caRe wOrkErS (HEROES) Study
Status: UNKNOWN
Conditions: Covid-19|Mental Health Disorder|Stress Disorder|Anxiety|Depression|SARS-CoV-2
Interventions: OTHER: Exposure to the SARS-CoV-2 and its consequences
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Detection of COVID-19 (SARS-CoV-2) in the Semen of COVID+ Patients (Positive RT-PCR on a Nasopharyngeal Swab)
Status: COMPLETED
Conditions: COVID
Interventions: DIAGNOSTIC_TEST: diagnostic
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Learn About Zavegepant as a Treatment for Multiple Migraine Attacks in Adult Participants
Status: NOT_YET_RECRUITING
Conditions: Migraine
Interventions: COMBINATION_PRODUCT: Zavegepant 10 mg|COMBINATION_PRODUCT: Placebo - Control 1|COMBINATION_PRODUCT: Placebo - Control 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Efficacy of Desvenlafaxine Succinate for Vasomotor Symptoms in Postmenopausal Women
Status: COMPLETED
Conditions: Menopause|Vasomotor System
Interventions: DRUG: Desvenlafaxine succinate sustained-release (DVS SR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Promoting Positive Care Interactions (PPCI) in Assisted Living
Status: NOT_YET_RECRUITING
Conditions: Alzheimer Disease and Related Dementias
Interventions: BEHAVIORAL: Promoting Positive Care Interactions (PPCI)|BEHAVIORAL: PPCI-Staff Education Only (EO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CliniMACS® CD34+ Reagent System for Expanded Access Use
Status: NO_LONGER_AVAILABLE
Conditions: Graft-Versus-Host Disease(GVHD)|Anemia Due to Disturbance of Proliferation and/or Differentiation of Hematopoietic Stem Cells|Graft Failure|Delayed Graft Function
Interventions: DEVICE: CliniMACS CD34 Reagent System
Study Type: EXPANDED_ACCESS