pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Ultrasound-guided Left Stellate Ganglion Block on Rapid Recovery of Patients Undergoing Cardiac Valve Replacement and Its Mechanism
Status: ACTIVE_NOT_RECRUITING
Conditions: Left Stellate Ganglion Block Can Quickly Restore the Left Stellate Ganglion|Possible Molecular Mechanism of Left Stellate Ganglion Block
Interventions: PROCEDURE: stellate ganglion block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cephalon Decitabine, Arsenic Trioxide and Ascorbic Acid for Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: Decitabine, Arsenic Trioxide and Ascorbic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Blind, Randomized, Placebo-controlled, Phase 2a, 2-cohort Study for the Evaluation of Safety and Efficacy of RZL-012 for Submental Fat Reduction in Healthy Volunteers.
Status: COMPLETED
Conditions: Submental Fat
Interventions: DRUG: RZL-012|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of ABI-007 for In-Stent Restenosis
Status: COMPLETED
Conditions: Angina Pectoris|Coronary Artery Disease
Interventions: DRUG: Paclitaxel Nanoparticle Albumin Bound|DRUG: Paclitaxel Nanoparticle Albumin Bound|DRUG: Paclitaxel Nanoparticle Albumin Bound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis (MS)|Relapsing-remitting Multiple Sclerosis (RRMS)|Secondary-progressive Multiple Sclerosis (SPMS)|Primary Progressive Multiple Sclerosis (PPMS)
Interventions: DIAGNOSTIC_TEST: MRI|OTHER: Neurocognitive examination for healthy subjects|OTHER: blood sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Preoperative Curcumin in Breast Cancer Patients
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DIETARY_SUPPLEMENT: Curcumin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: D-Cycloserine Augmentation of Therapy for Pediatric Obsessive-Compulsive Disorder
Status: COMPLETED
Conditions: Obsessive-compulsive Disorder
Interventions: BEHAVIORAL: Cognitive-behavioral therapy|DRUG: D-cycloserine|DRUG: Placebo pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study to Determine the Optimal Calibration Method for Glucose Sensors
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: Insulin dosing|DEVICE: Glucose sensors IR-Glucose Reader (Joanneum Research, Austria), IR-CGM (IMM, Germany)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Benadryl Sedation During ERCP or EUS
Status: WITHDRAWN
Conditions: Gallbladder Disease|Gallstones|Pancreatitis|Abdominal Pain|Jaundice
Interventions: DRUG: Benadryl versus Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Uninterrupted Dabigatran Etexilate in Comparison to Uninterrupted Warfarin in Pulmonary Vein Ablation (RE-CIRCUIT)
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Warfarin|DRUG: Dabigatran Etexilate 150mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RAMSETE: RAD001 in Advanced and Metastatic Silent Neuro-endocrine Tumors in Europe
Status: COMPLETED
Conditions: Advanced and Metastatic Silent Neuro-Endocrine Tumors|Carcinoma|Neuroendocrine|Non Functioning Neuroendocrine Tumors (NETs)|Non Syndromic Neuroendocrine Tumors|Carcinoids|Non Functioning
Interventions: DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heat Therapy to Prevent Deconditioning During Immobilization
Status: COMPLETED
Conditions: Hot Weather; Adverse Effect|Immobilization, Tonic
Interventions: OTHER: Hot ambient conditions exposures|OTHER: Immobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cannabidiol After Multi-Trauma for Pain and Opioid Therapy
Status: NOT_YET_RECRUITING
Conditions: Fracture
Interventions: DRUG: Cannabidiol|DRUG: Cannabidiol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inetetamab Combined With Pyrotinib Plus Oral Vinorelbine for the Treatment of HER2-positive Metastatic Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Inetetamab|DRUG: Pyrotinib|DRUG: Oral Vinorelbine Tartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LiveSpo Navax® Supports the Treatment of Acute Rhinosinusitis and Otitis Media
Status: COMPLETED
Conditions: Upper Respiratory Tract Infections
Interventions: DRUG: 0.9% NaCl physiological saline Nasal-spraying|COMBINATION_PRODUCT: LiveSpo Navax®|DRUG: Augmentin 500Mg Tablet|DRUG: Acetylcysteine|DRUG: Xylometazoline Nasal|DRUG: Cefotaxime|DRUG: Ciprofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Early Vitamin A Supplementation on the Risk for Retinopathy of Prematurity in Extremely Preterm Infants
Status: COMPLETED
Conditions: Retinopathy of Prematurity
Interventions: DRUG: Vitamin A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Postoperative Quality of Recovery After Transurethral Resection of the Bladder
Status: UNKNOWN
Conditions: Urinary Bladder Neoplasms|Transurethral Resection of the Bladder|Postoperative Recovery
Interventions: PROCEDURE: Spinal anesthesia|PROCEDURE: General anesthesia|DRUG: bupivacaine|DRUG: fentanyl|DRUG: propofol|DRUG: sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Propofol Midazolam on Cerebral Oxygenation and Metabolism During Clipping of Ruptured Cerebral Aneurysm
Status: COMPLETED
Conditions: Ruptured Cerebral Aneurysm
Interventions: DRUG: Total intravenous anesthesia (TIVA)|DRUG: Inhalation Anesthesia|DRUG: Rescue fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Topical Imiquimod vs. LEEP for Women With Carcinoma In-situ of the Cervix
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia
Interventions: DRUG: Imiquimod|PROCEDURE: Loop Electrosurgical Excision Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination Versus Insulin Glargine in Patients With Type 2 Diabetes (LixiLan-India)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: INSULIN GLARGINE/LIXISENATIDE (HOE901/AVE0010)|DRUG: INSULIN GLARGINE (HOE901)|DRUG: Metformin|DRUG: Insulin Glulisine (HMR1964)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pomegranate to Reduce Maternal and Fetal Oxidative Stress and Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of the Membranes
Status: UNKNOWN
Conditions: Preterm Premature Rupture of Membranes|Pregnant State
Interventions: DIETARY_SUPPLEMENT: Pomgranate pills|DIETARY_SUPPLEMENT: Placebo pills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-Eluting Bead, Irinotecan Therapy for Unresectable Intrahepatic Cholangiocarcinoma w/Concomitant Gemcitabine and Cisplatin or Carboplatin
Status: COMPLETED
Conditions: Unresectable Intrahepatic Cholangiocarcinoma
Interventions: DEVICE: LC or ONCOZENE Bead with Gem-Cis or Gem-Carbo|DRUG: Gem-Cis or Gem-Carbo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-center Clinical Trials of Sanjie Analgesic Capsule in Treating Endometriosis
Status: UNKNOWN
Conditions: Dysmenorrhea
Interventions: DRUG: Sanjie analgesic capsule|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Palbociclib Plus Fulvestrant in Women With Hormone Receptor Positive and Human Epidermal Growth Factor Receptor Type 2 Negative Locally Advanced or Metastatic Breast Cancer Previously Treated With a CDK4/6 Inhibitor in Combination With Hormonal Therapy
Status: UNKNOWN
Conditions: Metastatic Breast Cancer|Locally Advanced Breast Cancer
Interventions: DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of Fractionated Stereotactic Radiotherapy for Early Stage Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: RADIATION: Stereotactic Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Voices of Patients' Relatives to Support Weaning From Mechanical Ventilation
Status: COMPLETED
Conditions: Ventilator Weaning|Weaning Failure|Brain Injuries
Interventions: OTHER: Voice-Weaning|OTHER: Sham control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants
Status: ACTIVE_NOT_RECRUITING
Conditions: Epidemic Parotitis,Mumps
Interventions: BIOLOGICAL: ≥3.0 lgCCID50/mlbut <3.5lgCCID50/ml Live Attenuated Mumps Vaccine (Human Diploid Cell) in infants(8-24 months old)|BIOLOGICAL: ≥4.5 lgCCID50/ml Live Attenuated Mumps Vaccine (Human Diploid Cell) in infants(8-24 months old)|BIOLOGICAL: Measles and Mumps Combined Vaccine，Live(SIBP)( positive control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: IH636 Grape Seed Extract in Treating Hardening of Breast Tissue in Women Who Have Undergone Radiation Therapy for Early Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer|Radiation Fibrosis
Interventions: DIETARY_SUPPLEMENT: IH636 grape seed proanthocyanidin extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Aminocamptothecin in Treating Patients With Recurrent or Refractory Ovarian Epithelial Cancer or Primary Cancer of the Peritoneum
Status: COMPLETED
Conditions: Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: aminocamptothecin colloidal dispersion
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: First-in-human Phase I Study to Evaluate Safety, Tolerability and Antineoplastic Activity of OATD-02 in Patients With Selected Advanced and/or Metastatic Solid Tumours
Status: RECRUITING
Conditions: Advanced Ovarian Carcinoma|Advanced Renal Cell Carcinoma|Advanced Pancreatic Carcinoma|Advanced Colorectal Carcinoma|Metastatic Pancreatic Carcinoma|Metastatic Colorectal Carcinoma|Metastatic Renal Cell Carcinoma|Metastatic Ovarian Carcinoma
Interventions: DRUG: OATD-02
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Outcomes of Laparoscopic Cholecystectomy for Acute Cholecystitis Within and Beyond the First 72 Hours, Does it Differ?!
Status: NOT_YET_RECRUITING
Conditions: Acute Cholecystitis
Interventions: PROCEDURE: Laparoscopic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Probiotics in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia Spectrum Disorder (ALS-FTDSD) Patients
Status: NOT_YET_RECRUITING
Conditions: ALSFTD
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Drug-Drug Interaction Study Between Sotagliflozin and Ramipril
Status: COMPLETED
Conditions: Diabetes Mellitus|Healthy Subjects
Interventions: DRUG: Sotagliflozin (SAR439954)|DRUG: Ramipril
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of All-Oral Combination of Narlaprevir/Ritonavir and Sofosbuvir in Treatment-naïve Patients With Chronic Hepatitis C Genotype 1
Status: COMPLETED
Conditions: Chronic Hepatitis c Genotype 1
Interventions: DRUG: Narlaprevir|DRUG: Ritonavir|DRUG: Sofosbuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Surgical Techniques for CRIF of Pertrochanteric Fractures
Status: UNKNOWN
Conditions: Femur Fracture
Interventions: PROCEDURE: internal fixation (DHS - richard nail)|PROCEDURE: internal fixation (inflatable PFN by DISCOTEC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Hypoxemia, Lung Function Decline, Morbidity, and Mortality in COPD (PROSA Study).
Status: NOT_YET_RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: OTHER: No active intervention, but observational follow-up
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cervicovestibular Physiotherapy and Aerobic Exercise in Concussion
Status: UNKNOWN
Conditions: Concussion
Interventions: OTHER: Cervicovestibular Physio (CV PT)|OTHER: Low-Level Aerobic Exercise (LLAE)|OTHER: Combination (LLAE and CV PT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Treatment Protocol for Selective Laser Trabeculoplasty
Status: ACTIVE_NOT_RECRUITING
Conditions: Glaucoma, Open-Angle|Pseudoexfoliation Glaucoma|Ocular Hypertension
Interventions: PROCEDURE: SLT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The SCRIPPS DES REAL WORLD Registry
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Restenosis|Coronary Thrombosis
Interventions: DEVICE: Sirolimus-Eluting Bx Velocity Coronary Stent (CypherTM Sirolimus-Eluting Stent)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Combination Therapy With Mogamulizumab (KW-0761) and Nivolumab (ONO-4538/BMS-936558) in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor
Interventions: BIOLOGICAL: Mogamulizumab: KW-0761, Nivolumab: (ONO-4538/BMS-936558)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 1 Year Trial Telmisartan 80 mg Versus Valsartan 160 mg in Hypertensive Type 2 Diabetic Patients With Overt Nephropathy
Status: COMPLETED
Conditions: Diabetic Nephropathies|Hypertension
Interventions: DRUG: Telmisartan|DRUG: Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effect of Dapagliflozin Combined With CSII on Newly Diagnosed Type 2 Diabetes Mellitus
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Dapagliflozin 10 MG|DRUG: Insulin Aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Radiation Induced Cystitis Treated With Hyperbaric Oxygen - A Randomized Controlled Trial
Status: COMPLETED
Conditions: Cystitis, Radio Induced
Interventions: DRUG: Hyperbaric Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of the Training on Adaptation to Treatment Provided to Hemodialysis Patients According to the Neuman Systems Theory on Self-Esteem and Perceived Social Support
Status: COMPLETED
Conditions: Nursing
Interventions: OTHER: Patient education|OTHER: Data Collecting, No Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Provant Therapy of Venous Stasis Ulcer Trial
Status: UNKNOWN
Conditions: Venous Stasis Ulcers
Interventions: DEVICE: Provant Device (Wound Therapy System)|DEVICE: Provant Device - Inactive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Immunogenicity of ALVAC-HIV and MF59®- or AS01B-adjuvanted Bivalent Subtype C gp120 in Healthy, HIV-uninfected Adult Participants
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: ALVAC-HIV (vCP2438)|BIOLOGICAL: Bivalent subtype C gp120/MF59|BIOLOGICAL: Bivalent subtype C gp120/AS01(B)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Ureteral Patency in the Post-indigo Carmine Era
Status: COMPLETED
Conditions: Ureteral Patency
Interventions: DRUG: Pyridium|DRUG: Sodium Fluorescein|DRUG: Mannitol|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy, Safety, Tolerability and Pharmacokinetics of KAF156 in Adult Patients With Acute, Uncomplicated Plasmodium Falciparum or Vivax Malaria Mono-infection
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: KAF156
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Therapy in Treating Patients With Cancer of the Bile Duct, Gallbladder, or Pancreas
Status: COMPLETED
Conditions: Extrahepatic Bile Duct Cancer|Gallbladder Cancer|Liver Cancer|Pancreatic Cancer
Interventions: DRUG: porfimer sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparison of Cross-cylinder and Conventional Photorefractive Keratectomy(PRK) in Correcting Medium-high Astigmatism
Status: COMPLETED
Conditions: Astigmatism
Interventions: PROCEDURE: photorefractive keratectomy (PRK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Low Oxygen Therapy to Enhance Walking Recovery After SCI.
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injuries
Interventions: OTHER: Daily acute intermittent hypoxia|DEVICE: Walking + tSTIM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enzalutamide in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma
Status: TERMINATED
Conditions: Ann Arbor Stage I Mantle Cell Lymphoma|Ann Arbor Stage II Mantle Cell Lymphoma|Ann Arbor Stage III Mantle Cell Lymphoma|Ann Arbor Stage IV Mantle Cell Lymphoma|Recurrent Mantle Cell Lymphoma|Refractory Mantle Cell Lymphoma
Interventions: DRUG: Enzalutamide|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Lumacaftor in Combination With Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older Who Are Homozygous for the F508del-CFTR Mutation
Status: COMPLETED
Conditions: Cystic Fibrosis, Homozygous for the F508del CFTR Mutation
Interventions: DRUG: Lumacaftor Plus Ivacaftor Combination|DRUG: Ivacaftor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preserving Autonomy Through Foot Health: a Study on the Acceptability of a Program Including Various Workshops for the Elderly
Status: COMPLETED
Conditions: Falling
Interventions: OTHER: Program Including Various Workshops aiming to preserve elderly's autonomy through foot health
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Gall Stone Disease
Interventions: DRUG: Lidocaine|DRUG: Esmolol|DRUG: Paracetamol|DRUG: Lidocaine|DRUG: Propofol|DRUG: Fentanyl|DRUG: Vecuronium|DRUG: Atropine|DRUG: Ephedrine|DRUG: Morphine|DRUG: Ketorolac|DRUG: Ondansetron|DRUG: Bupivacaine|DRUG: Tramadol|DRUG: Neostigmine|DRUG: Glycopyrrolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Sucess of Pulpotomy, Direct Pulp Capping and Indirect Pulp Capping Modalities Using MTA in Primary Teeth
Status: UNKNOWN
Conditions: Deep Caries
Interventions: OTHER: Vital pulp therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenetics of Naltrexone for Stimulant Abuse
Status: COMPLETED
Conditions: Substance Use Disorders|Methamphetamine Abuse
Interventions: DRUG: Intranasal Methamphetamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Acute Effect of Cheeses With Different Energy Content on Appetite
Status: COMPLETED
Conditions: Appetite; Lack or Loss, Nonorganic Origin
Interventions: OTHER: High protein/high fat hard cheese|OTHER: High protein/low fat hard cheese|OTHER: Low protein/high fat creme cheese
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Characterization of Cyanocobalamin in Healthy Voluteers After Intranasal and Intramuscual Administration
Status: COMPLETED
Conditions: Focus: Bioavailability
Interventions: DRUG: Nascobal nasal spray (cyanocobalamin, USP)|DRUG: Vitamin B12-ratiopharm N, injection solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Demonstrating the Clinical and Economic Benefit of 5 Alpha Reductase Inhibitor Adherence in Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Prostatic Hyperplasia
Interventions: DRUG: Adherent with 5-alpha-reductase inhibitor (5ARI) therapy|DRUG: Non-adherent to 5ARI therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Exenatide on 24-Hour Blood Glucose Profile Compared With Placebo in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: exenatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Belantamab Mafodotin to Investigate Safety, Tolerability, Pharmacokinetics, Immunogenicity and Clinical Activity in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Belantamab mafodotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Bone Marrow Transplantation With Matched Unrelated Donors for Patients With Hematologic Malignancies
Status: COMPLETED
Conditions: Hematologic Malignancies
Interventions: DRUG: Busulfan, Cyclophosphamide and Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept Study Assessing Technology-Assisted Respiratory Adherence Prototype Version 3 in Individuals With COPD
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DEVICE: TARA v3.1, only non-pharmacological self-management support|DEVICE: TARA v3.2, both non-pharmacological and pharmacological self-management support
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Exploratory Study of FP01 Lozenges in Subjects With Chronic Refractory Cough
Status: COMPLETED
Conditions: Chronic Refractory Cough
Interventions: DRUG: FP01|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Engaging Mothers & Babies; Reimagining Antenatal Care for Everyone (EMBRACE) Study
Status: RECRUITING
Conditions: Premature Birth|Pregnancy Preterm|Prenatal Stress|Depression, Anxiety|Depression, Postpartum|Satisfaction, Patient|Health Problems in Pregnancy
Interventions: OTHER: Glow! Group Prenatal Care|OTHER: Individual Prenatal Care with CPSP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Letrozole Plus Ribociclib or Placebo as Neo-adjuvant Therapy in ER-positive, HER2-negative Early Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Letrozole|DRUG: Ribociclib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Multimodal Radiotherapy for Renal Cell Carcinoma Progressed After Prior Immunotherapy
Status: RECRUITING
Conditions: Renal Cell Carcinoma|Radiotherapy|Immune Checkpoint Inhibitor
Interventions: RADIATION: High-dose Radiotherapy (HDRT)|RADIATION: Low-dose Radiotherapy (LDRT)|DRUG: Anti-PD-1 monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone Marrow Derived Stem Cell Transplantation in T2DM
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: BIOLOGICAL: mesenchymal stem cell transplantation|OTHER: control|BIOLOGICAL: MNC's TRANSPLANTATION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Botulinum Toxin in Neurogenic Bladders in Children With Myelomeningocele
Status: UNKNOWN
Conditions: Myelomeningocele|Bladder, Neurogenic
Interventions: DRUG: Botulinum A toxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Surgical Hand Antisepsis With Propan-ol-1 60% Per Rubbing and Scrubbing
Status: COMPLETED
Conditions: Skin Diseases|Surgical Site Infection
Interventions: DRUG: Hand antisepsis by scrub|DRUG: Hand antisepsis by scrub
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Intensive 3-round MDA Strategy Towards Yaws Eradication
Status: COMPLETED
Conditions: Yaws
Interventions: DRUG: R1-Total community treatment with azithromycin|DRUG: R2-Total community treatment with azithromycin|DRUG: R3-Total community treatment with azithromycin|DRUG: R2-Total targeted treatment with azithromycin|DRUG: R3-Total targeted treatment with azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tivozanib in Treating Patients With Liver Cancer That Is Metastatic or Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Advanced Adult Hepatocellular Carcinoma|Non-Resectable Hepatocellular Carcinoma
Interventions: DRUG: Tivozanib (1mg)|DRUG: Tivozanib (1.5mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction Chemo Then Concurrent Chemoradiotherapy With Cetuximab in Locally Advanced Head and Neck Squamous Cell Cancer
Status: TERMINATED
Conditions: Head and Neck Squamous Cell Cancer
Interventions: DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial With Combination of Dienogest/Ethytnilestradiol and Drosperidona/Ethyniestradiol
Status: WITHDRAWN
Conditions: Metrorrhagia
Interventions: DRUG: barrier methods|DRUG: barrier methods
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Neoadjuvant Intensity-Modulated Radiation Therapy Followed by Surgery and Intraoperative Radiation Therapy in Resectable Retroperitoneal Soft Tissue Sarcoma (RETRO-WTS)
Status: COMPLETED
Conditions: Retroperitoneal Soft Tissue Sarcoma
Interventions: RADIATION: Neoadjuvant intensity-modulated radiation therapy (IMRT)|RADIATION: intraoperative radiation therapy (IORT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Percutaneous Tracheostomy and Swallowing Dysfunction
Status: UNKNOWN
Conditions: Swallowing Disorder
Interventions: PROCEDURE: Percutaneous tracheostomy|PROCEDURE: Prolonged translaryngeal intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Temozolomide in Previously Untreated Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Participants With Low O6-Methylguanine Methyltransferase (MGMT) Expression (P05052)
Status: COMPLETED
Conditions: Leukemia, Acute Myeloid|Myelodysplastic Syndrome
Interventions: DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CART-EGFR-IL13Ra2 in EGFR Amplified Recurrent GBM
Status: RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: CART-EGFR-IL13Ra2 Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multimodal Approach for Clinical Diagnosis and Treatment of Primary Progressive Aphasia, MAINSTREAM ID:3430931
Status: RECRUITING
Conditions: Primary Progressive Aphasia
Interventions: DEVICE: Active tDCS|BEHAVIORAL: individualized language training|DEVICE: Placebo tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of HIV and/or Active Tuberculosis on the Immune Responses to Trivalent Influenza Vaccine (TIV) in Adults
Status: COMPLETED
Conditions: Influenza|HIV|Tuberculosis
Interventions: BIOLOGICAL: Trivalent Inactivated Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Feasibility of the Portable YouGrabber System
Status: COMPLETED
Conditions: Cerebral Palsy|Stroke|Traumatic Brain Injury|Meningomyelocele|Central Nervous System Diseases
Interventions: DEVICE: YouGrabber
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study to Evaluate the Impact of Maximal Urethral Length Preservation Technique During Robotic Laparoscopic Prostatectomy on the Stretched Flaccid Penile Length and Continence
Status: COMPLETED
Conditions: Prostate Adenocarcinoma|Incontinence Stress|Erectile Dysfunction Following Radical Prostatectomy
Interventions: PROCEDURE: Maximal urethral length preservation technique of robot assisted radical prostatectomy (RALP).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Post-sleeve Gastrectomy Gastroesophageal Reflux Disease Prediction
Status: RECRUITING
Conditions: Gastroesophageal Reflux|Sleeve Gastrectomy|Bariatric Surgery Complication
Interventions: DEVICE: EndoFLIP measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: ASSET - a Double-Blind, Randomized Placebo-Controlled Clinical Investigation With Alteco® LPS Adsorber
Status: TERMINATED
Conditions: Septic Shock
Interventions: DEVICE: Alteco LPS Adsorber|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Health Mindset as a Driver of Efficacy of a Diabetes Prevention Program in the Blackfeet Community
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Diabetes Prevention Program|BEHAVIORAL: Health Mindset modified diabetes prevention program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bone Graft Materials Observational Registry
Status: TERMINATED
Conditions: Degenerative Disc Disease|Herniated Disc|Spinal Stenosis|Spondylolithesis|Spinal Deformity|Cervical Myelopathy|Failed Back Surgery Syndrome|Spinal Cord Neoplasms
Interventions: DEVICE: Bone graft substitute, autograft or allograft
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Study to Assess the Efficacy and Safety of AT-5214 in the Treatment of Subjects With Palmar Hyperhidrosis
Status: UNKNOWN
Conditions: Hyperhidrosis|Palmar Hyperhidrosis
Interventions: DRUG: Dexmecamylamine HCl|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotic Blend for Celiac Disease
Status: RECRUITING
Conditions: Celiac Disease
Interventions: DIETARY_SUPPLEMENT: Probiotic blend|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term Follow-up of Cervical Myelopathy Inpatients Treated With Integrated Complementary and Alternative Medicine
Status: COMPLETED
Conditions: Cervical Myelopathy
Interventions: DRUG: Herbal medicine|PROCEDURE: Chuna manual medicine|PROCEDURE: Pharmacopuncture|PROCEDURE: Acupuncture|PROCEDURE: Electroacupuncture|PROCEDURE: Cupping|PROCEDURE: Other intervention(s)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tisotumab Vedotin (HuMax®-TF-ADC) Safety Study in Patients With Solid Tumors
Status: COMPLETED
Conditions: Ovary Cancer|Cervix Cancer|Endometrium Cancer|Bladder Cancer|Prostate Cancer (CRPC)|Esophagus Cancer|Lung Cancer(NSCLC)|Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Interventions: DRUG: Tisotumab Vedotin (HuMax-TF-ADC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Umbilical Cord Mesenchymal Stem Cell Transplantation for Type 1 Diabetes With Diabetic Ketoacidosis
Status: UNKNOWN
Conditions: Ketoacidosis, Diabetic
Interventions: PROCEDURE: umbilical cord mesenchymal stem cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcome of Cerebral Venous Sinuses Stenting on Idiopathic Intracranial Hypertension
Status: UNKNOWN
Conditions: Idiopathic Intracranial Hypertension
Interventions: PROCEDURE: Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fetal Tracheal Balloon Study in Diaphragmatic Hernia
Status: TERMINATED
Conditions: Diaphragmatic Hernia|Lung Disease
Interventions: DEVICE: Fetal tracheal obstruction with detachable balloon (device)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Longitudinal Relationship of HU Adherence to HRQOL, Barriers to Adherence and Habit in SCD.
Status: ACTIVE_NOT_RECRUITING
Conditions: Sickle Cell Disease|Sickle B+ Thalassemia|Sickle Beta Zero Thalassemia|Sickle Cell Hemoglobin C
Interventions: OTHER: HU-Go app
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: In-patient Smoking Cessation Intervention Using Counseling, Spirometry and Nicotine Replacement Therapy
Status: UNKNOWN
Conditions: Smoking Cessation
Interventions: DRUG: Nicotine replacement therapy|BEHAVIORAL: Intensive counseling|BEHAVIORAL: Medical advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of the Copenhagen Adduction Exercise on Soccer Players With Groin Pain or Injury
Status: COMPLETED
Conditions: Groin Injury
Interventions: OTHER: Copenhagen adduction exercise|OTHER: Usual rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multiple Oral Doses Study Of PF-06427878 In Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: PF-06427878|DRUG: Placebo|DRUG: PF-06427878|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacokinetic Profile of Four Formulations of Fluticasone Furoate (FF) Using Unit Dose Dry Powder Inhaler (UD-DPI) Compared With FF ELLIPTA® Presentation
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: FF UD-DPI|DRUG: FF ELLIPTA DPI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prasugrel in Severe COVID-19 Pneumonia
Status: UNKNOWN
Conditions: COVID19|Thrombosis
Interventions: DRUG: Prasugrel Hydrochloride 10 MG Oral Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Calling for Care: Cell Phones for Mood Telemetry in Teens
Status: COMPLETED
Conditions: Bipolar Disorder|Cyclothymia|Borderline Personality Disorder
Interventions: OTHER: Mental health telemetry (MHT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immuno-bridging Study of Inactivated SARS-CoV-2 Vaccine in Healthy Population Aged 3-17 vs Aged 18 Years Old and Above
Status: COMPLETED
Conditions: COVID-19 Pneumonia|COVID-19
Interventions: BIOLOGICAL: SARS-CoV-2 Vaccine (Vero Cell), Inactivated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Taping in Reducing the Intensity of Pain in Primary Dysmenorrhea
Status: COMPLETED
Conditions: Primary Dysmenorrhea
Interventions: DEVICE: Medical taping|DRUG: Analgesic self-medication (OTC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Corneal Tear Film Imaging of the Cornea Before and After Restasis Therapy
Status: UNKNOWN
Conditions: Dry Eye Syndrome|Tear Film Insufficiency
Interventions: DEVICE: Tear Film Imager|DRUG: Restasis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Tiotropium + Olodaterol on Breathlessness in COPD Patients
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium|DRUG: Olodaterol|DRUG: Tiotropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 /Seroquel SR Acute Mania Monotherapy - US
Status: COMPLETED
Conditions: Affective Psychosis, Bipolar|Manic Disorder|Manic-Depressive Psychosis|Mania|Manic State|Psychoses, Manic-Depressive
Interventions: DRUG: Quetiapine fumarate (Seroquel) SR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Step Rate Retraining to Reduce Injury and Disability (STRIDe)
Status: UNKNOWN
Conditions: Overuse Injury|Lower Extremity Problem|Stress Injury, Repetitive|Patellofemoral Pain Syndrome|Shin Splint
Interventions: OTHER: Run Gait Retraining
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Determine Therapeutic Massage Dosing to Improve Quality of Life in Hospitalized Patients Receiving Palliative Care
Status: COMPLETED
Conditions: Cancer|Heart Failure|COPD|Sepsis|HIV Infections|ESRD|Trauma|Stroke
Interventions: OTHER: Therapeutic massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Everolimus Plus Mycophenolic Acid for Kidney Preservation in Liver Transplant Recipients With Impaired Kidney Function
Status: TERMINATED
Conditions: Kidney Failure
Interventions: DRUG: Tacrolimus|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Tocilizumab Real-Life Human Factors (RLHFs) Validation Study
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DEVICE: AI-1000 G2|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Low GI Diet in Children and Adolescents With ALL
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphoblastic Leukemia, Pediatric|Obesity, Pediatric
Interventions: BEHAVIORAL: Low Glycemic Index Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase 1 Study of SL-172154 (SIRPα-Fc-CD40L) in Subjects With Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Carcinoma
Interventions: DRUG: SL-172154
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aspirin for Venous Ulcers: Randomised Trial (AVURT)
Status: TERMINATED
Conditions: Venous Leg Ulcer
Interventions: DRUG: Aspirin|DRUG: Placebo (for Aspirin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Modified mRNA Vaccines in Healthy Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: SARS-CoV-2|Seasonal Influenza|Respiratory Syncytial Virus|Cytomegalovirus
Interventions: BIOLOGICAL: mRNA-1273|BIOLOGICAL: mRNA-1010|BIOLOGICAL: mRNA-1345|BIOLOGICAL: FLUAD®|BIOLOGICAL: mRNA-1647
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Proglumide With Gemcitabine and Nab-Paclitaxel in PatientsWith Metastatic Pancreatic Ductal Adenocarcinoma
Status: WITHDRAWN
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Nab paclitaxel|DRUG: Proglumide Dose level 1|DRUG: Proglumide Dose level 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Facilitating Adjustment to Simulated Jet Lag
Status: UNKNOWN
Conditions: Circadian Rhythm Sleep Disorder, Jet Lag Type
Interventions: BEHAVIORAL: Bright Light|BEHAVIORAL: Bright Light + Exercise + Melatonin|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE