pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Dose Escalation Study of PF-06650808 in Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Neoplasms|Breast Cancer
Interventions: DRUG: PF-06650808|DRUG: PF-06650808
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab in New Onset Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Anti-CD20 (rituximab)|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Heme Oxygenase in the Pathogenesis of Hepatocellular Injury in Chronic Hepatitis C Virus (HCV) Infection
Status: UNKNOWN
Conditions: Chronic HCV Infection|Nonalcoholic Steatohepatitis
Interventions: DRUG: pegylated interferon|DRUG: Ribavarin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Simulated Passive Jogging Device on Glucose Homeostasis, Muscle Strength and Endurance
Status: COMPLETED
Conditions: Diabetes Mellitus|Glucose Metabolism Disorders|Physical Activity
Interventions: DEVICE: Gentle Jogger
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The MARS® Albumin Dialysis System in Patients With Fulminant and Subfulminant Hepatic Failure
Status: COMPLETED
Conditions: Hepatitis
Interventions: DEVICE: Molecular Adsorbent Recirculating System (MARS®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Mental Response - The EMRE Study
Status: RECRUITING
Conditions: Gender Dysphoria|Gender Identity|Gender Issues
Interventions: DRUG: Testosterone treatment|OTHER: Placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intravenous Subdissociative-dose Ketamine Versus Morphine for Prehospital Analgesia
Status: TERMINATED
Conditions: Pain Management
Interventions: DRUG: Ketamine|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Opioid-sparing Effect of Intranasal Dexmedetomidine
Status: COMPLETED
Conditions: Tonsillar Hypertrophy
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Repeat Dosing of GSK1521498
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Zolpidem or placebo - Hypnotic drug given for sleep disorders|DRUG: GSK1521498 or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Induction Docetaxel, Cisplatin and 5-Fluorouracil
Status: TERMINATED
Conditions: Squamous Cell Carcinoma|Oral Cancer
Interventions: DRUG: Docetaxel|DRUG: Cisplatin|DRUG: 5-fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pyrotinib Plus Capecitabine Versus Lapatinib Plus Capecitabine in Patients With HER2+ Metastatic Breast Cancer. (PHOEBE)
Status: UNKNOWN
Conditions: HER2 Positive Metastatic Breast Cancer
Interventions: DRUG: Pyrotinib Plus Capecitabine|DRUG: Lapatinib Plus Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Laboratory Evaluation of Chronic Autonomic Failure
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson's Disease|Multiple System Atrophy|Autonomic Failure
Interventions: DRUG: 13N-Ammonia|DRUG: 18F-DOPA|DRUG: 11C-Methylreboxetine (11C-MRB)|DRUG: 18F-Dopamine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetics and Safety of ABT-493 and/or ABT-530 in Subjects With Normal and Impaired Hepatic Function
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: ABT-493|DRUG: ABT-530
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Remote Ischemic Conditioning on Blood Pressure in Older Patients With Hypertension
Status: RECRUITING
Conditions: Essential Hypertension
Interventions: PROCEDURE: Remote ischemic conditioning|PROCEDURE: Sham remote ischemic conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peripheral Nerve Block Compared to Intra-articular Injection for TAA Post-operative Pain
Status: UNKNOWN
Conditions: Ankle Arthritis|Ankle Arthropathy
Interventions: PROCEDURE: Intra-articular injection|PROCEDURE: Peripheral nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, PK, PD, Immunogenicity and Efficacy of TWP-102 in Patients With Advanced Malignancies.
Status: UNKNOWN
Conditions: Advanced Malignancies
Interventions: DRUG: TWP-102 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ph+/Bcr-Abl+ ALL Imatinib and Nilotinib Rotational Study
Status: COMPLETED
Conditions: Treatment|Stem Cell Transplantation
Interventions: DRUG: Nilotinib|DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel With or Without Carboplatin and/or Bevacizumab Followed by Doxorubicin and Cyclophosphamide in Treating Patients With Breast Cancer That Can Be Removed by Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Male Breast Carcinoma|Stage IIA Breast Cancer AJCC v6 and v7|Stage IIB Breast Cancer AJCC v6 and v7|Stage IIIA Breast Cancer AJCC v7|Triple-Negative Breast Carcinoma
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Carboplatin|DRUG: Cyclophosphamide|DRUG: Doxorubicin Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of a Breathlessness Intervention Service for Intractable Breathlessness
Status: UNKNOWN
Conditions: Dyspnea
Interventions: BEHAVIORAL: Breathlessness Intervention Service|BEHAVIORAL: Best supportive care (Standard Care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Clinical Performance and Safety of Treatments in Degenerative Meniscopathy With Injection of Polynucleotides
Status: RECRUITING
Conditions: Meniscus Tear|Meniscus Lesion
Interventions: PROCEDURE: partial meniscectomy|DEVICE: Condrotide® (polynucleotides gel: class III medical device)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study With AZD2171 in Patients With Advanced Solid Malignant Tumors and Liver Metastases
Status: COMPLETED
Conditions: Advanced Solid Tumor|Liver Metastases
Interventions: DRUG: AZD2171
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain and Oculometric Markers of Emotional Facial Expression Recognition Deficits
Status: RECRUITING
Conditions: Autism|Psychotic Disorders
Interventions: OTHER: Electroencephalogram and eye-tracking recordings
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Controlled Trial of LUtein as a Novel Neuroprotective Adjunctive Therapy to Improve Visual Outcome of Rhegmatogenous Retinal Detachment (LUNAR Study)
Status: COMPLETED
Conditions: Retinal Detachment
Interventions: DIETARY_SUPPLEMENT: Lutein|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Vi-DT Typhoid Conjugate Vaccine in Indonesian Adults, Adolescents, Children and Infants
Status: COMPLETED
Conditions: Safety Issues|Immunogenicity
Interventions: BIOLOGICAL: Vi-DT Vaccine|BIOLOGICAL: Vi Polysaccharide Vaccine|BIOLOGICAL: IPV Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness-based Interventions in COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease Exacerbation
Interventions: BEHAVIORAL: digital mindfulness-based intervention (MBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Liposomal Bupivacaine on Post Operative Pain and Narcotic Use After Bariatric Surgery
Status: COMPLETED
Conditions: Bariatric Surgery Candidate|Pain, Postoperative
Interventions: DRUG: Exparel 266 MG Per 20 ML Injection|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sarpogrelate-Aspirin Comparative Clinical Study for Efficacy and Safety in Secondary Prevention of Cerebral Infarction (S-ACCESS)
Status: COMPLETED
Conditions: Cerebral Infarction
Interventions: DRUG: MCI-9042|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Benzac 5% Gel in Combination With Cosmetic Products in Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Benzoyl Peroxide|OTHER: Dermotivin® Soft Liquid cleanser|OTHER: Cetaphil® Dermacontrol Moisturizer SPF30
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison Between Land-based and Water-based Exercises for Knee Osteoarthritis: Randomized Controlled Trial
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: water-based exercises|OTHER: land-based exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nitrogen Balance in Infants After Post Cardiothoracic Surgery
Status: COMPLETED
Conditions: Congenital Heart Disease
Interventions: DIETARY_SUPPLEMENT: Standard protein delivery|DIETARY_SUPPLEMENT: Intervention 1 (2.2g/kg/day)|DIETARY_SUPPLEMENT: Intervention 2 (3.0 g/kg/day)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomized Control Trial (RCT) of Transarterial Chemoembolization (TACE) Versus TACE and Oral Drug Therapy in the Treatment of Unresectable Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Physical Activity On Memory, Cognitive Performance and Brain Activity
Status: COMPLETED
Conditions: Mental Health Wellness 1
Interventions: BEHAVIORAL: Small-sided soccer game|BEHAVIORAL: Walking soccer game|BEHAVIORAL: Rest group watching soccer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Magnesium and Vascular Stiffness
Status: COMPLETED
Conditions: Metabolic Syndrome|Obesity
Interventions: DIETARY_SUPPLEMENT: Magnesium Citrate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Method Pilates X Pilates in Water Postural Alignment and Its Correlation With Respiratory Capacity With Hemiparesis Spastic
Status: UNKNOWN
Conditions: Stroke
Interventions: OTHER: Mat Pilates|OTHER: Water Pilates
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2a Study of JAB-21822 Plus JAB-3312 in Patients With Advanced Solid Tumors Harboring KRAS p.G12C Mutation
Status: RECRUITING
Conditions: KRAS P.G12C|Non-small Cell Lung Cancer|Colorectal Cancer|Pancreatic Ductal Carcinoma
Interventions: DRUG: JAB-21822|DRUG: JAB-3312
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation on the Safety of Avocado Pulp Lipids
Status: COMPLETED
Conditions: Obesity|Avocado|Overnutrition|Nutritional Disorder|Metabolic Disease|Lipid Metabolism Disorders
Interventions: DIETARY_SUPPLEMENT: AvoMax (Low Dose)|DIETARY_SUPPLEMENT: AvoMax (High Dose)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving the Humoral Response to Influenza Vaccine in Lung Transplant Recipients by an Intradermal Strategy
Status: COMPLETED
Conditions: Lung Transplantation|Influenza Vaccines
Interventions: BIOLOGICAL: Trivalent Inactivated Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of a European Training Program for Robotic Liver Surgery (LIVEROBOT)
Status: NOT_YET_RECRUITING
Conditions: Liver Diseases|Liver Neoplasm|Liver Cancer|Liver Metastases|Biliary Tract Cancer|Biliary Tract Neoplasms|Biliary Tract Diseases
Interventions: OTHER: European Multicentre Training Program for Robotic Liver Surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cochlear Implantation in Cases of Single-Sided Deafness
Status: COMPLETED
Conditions: Unilateral Moderate to Profound Hearing Loss|Asymmetric Hearing Loss|Single-Sided Deafness (SSD)
Interventions: DEVICE: Cochlear Implant|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective, Multicenter Trial to Investigate the Safety and Efficacy of Percutaneous Tibial Nerve Stimulation for the Treatment of Fecal Incontinence
Status: TERMINATED
Conditions: Fecal Incontinence
Interventions: DEVICE: Urgent(R) PC Neuromodulation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes
Status: RECRUITING
Conditions: Epilepsy in Children|Dyskinesias|Movement Disorders in Children|Neurologic Disorder|Chorea|Myoclonus|Ataxia|Epilepsy|Dystonia Disorder|Movement Disorders
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Feasibility of Bronchial Washing Fluid for Molecular Testing With Next Generation Sequencing in Lung Cancer
Status: RECRUITING
Conditions: Lung Cancer
Interventions: DIAGNOSTIC_TEST: Ultrathin bronchoscopy with intratumoral washing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treatment of Periorbicular Hyperchromia Comparing 10% Thioglycolic Acid Peeling Versus Pulsed Intense Light
Status: UNKNOWN
Conditions: Periorbital Disorder
Interventions: DRUG: Thioglycolic Acid|DEVICE: Intense Pulsed Light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Analysis of Combining Desmopressin With Docetaxel for the Treatment of Castration-Resistant Prostate Cancer
Status: UNKNOWN
Conditions: Castrate Resistance Prostate Cancer
Interventions: DRUG: Desmopressin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Polyglycolic Acid Mesh Prevents Cerebrospinal Fluid Leakage
Status: RECRUITING
Conditions: Pituitary Tumor|Cerebrospinal Fluid Leakage
Interventions: DEVICE: polyglycolic acid(Neoveil)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coital Pharmacokinetics/Pharmacodynamics (PK/PD) of Tenofovir Gel
Status: COMPLETED
Conditions: Pharmacokinetics of 1% Tenofovir Gel Following Coitus|Pharmacodynamics of 1% Tenofovir Gel Following Coitus
Interventions: DRUG: 1% Tenofovir Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: GNT0006 Gene Therapy Trial in Patients With LGMDR9
Status: RECRUITING
Conditions: LGMDR9
Interventions: OTHER: GNT0006|OTHER: Day 0: Placebo|OTHER: Day 0: GNT0006|OTHER: Day 365 (year 1): Placebo|OTHER: Day 365 (year 1): GNT0006
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Estrogen Therapy Against Adhesion Reformation After Hysteroscopic Adhesiolysis
Status: UNKNOWN
Conditions: Intrauterine Adhesion
Interventions: DEVICE: disposable balloon uterine stent|PROCEDURE: dried biological amnion graft|DRUG: estradiol valerate tablets+dydrogesterone tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Early Double Sequential Defibrillation in Out-of-hospital Cardiac Arrest
Status: RECRUITING
Conditions: Cardiac Arrest|Fibrillation, Ventricular|Sudden Cardiac Death|Sudden Cardiac Arrest
Interventions: DEVICE: Double Sequential Defibrillation (DSD)|DEVICE: Standard defibrillation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of the Effect of Prophylactic Intraligamentary Injection of Dexamethasone and Piroxicam on Postoperative Pain in Teeth With Symptomatic Irreversible Pulpitis
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Dexamethasone sodium phosphate|DRUG: Piroxicam Injectable Solution|DRUG: Mepivacaine HCL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pain Reduction and Changes in Upper Limb Function Produced by an Ibuprofen Treatment in Carpal Tunnel Syndrome.
Status: UNKNOWN
Conditions: Carpal Tunnel Syndrome|Ibuprofen|Pain Management|Pain, Chronic
Interventions: DRUG: Ibuprofen tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dual Anti-CD22/CD19 Chimeric Antigen Receptor-directed T Cells (CART2219.1) for Relapsed Refractory B-Lineage Leukaemia
Status: RECRUITING
Conditions: Lymphoblastic Leukemia|Lymphoblastic Leukemia, Acute, Childhood|Lymphoblastic Leukemia in Children|Lymphoblastic Leukemia, Acute Adult|CAR
Interventions: BIOLOGICAL: Phase I|BIOLOGICAL: Phase II
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioimpedance Measurement of Abdominal Free Flaps During Arterial and Venous Weaning in Breast Reconstruction
Status: RECRUITING
Conditions: Breast Reconstruction|Thrombosis, Venous|Bioimpedance Measurement Capacity
Interventions: DEVICE: portable prototype of bioimpedance measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study of Bavituximab and Sorafenib In Patients With Advanced Liver Cancer
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Liver Cancer
Interventions: DRUG: bavituximab (0.3 mg/kg) and sorafenib|DRUG: bavituximab (1.0 mg/kg ) and sorafenib|DRUG: bavituximab (3.0 mg/kg) and sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tango for Neuropathy Among Breast Cancer Survivors
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer, Breast|Neuropathy
Interventions: BEHAVIORAL: Rhythmic Auditory Stimulation|BEHAVIORAL: Evidence-Based Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Muscadine Grape Extract in Men With Prostate Cancer on Androgen Deprivation Therapy
Status: RECRUITING
Conditions: Recurrent Prostate Cancer
Interventions: DRUG: MGE|OTHER: Placebo|OTHER: ADT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TUNE! Teaching the UK About Noise Exposure: A Pilot Study
Status: COMPLETED
Conditions: Noise-induced Hearing Loss and Tinnitus
Interventions: OTHER: Modified Audio video|OTHER: Unmodified audio video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety of Oral VT-1161 in Patients With Moderate - Severe Interdigital Tinea Pedis
Status: COMPLETED
Conditions: Tinea Pedis
Interventions: DRUG: VT-1161|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Alemtuzumab Given in Combination With CHOP and ESHAP in Patients Newly Diagnosed With Peripheral T-Cell Lymphoma (PTCL)
Status: COMPLETED
Conditions: Peripheral T-cell Lymphoma
Interventions: DRUG: CHOP regimen alternate with ESHAP regimen|DRUG: Alemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Extension Trial in Subjects With Atopic Dermatitis Who Participated in Previous Tralokinumab Trials - ECZTEND
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Tralokinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D in OUD: Exploration of Alterations on the Dopamine D2/D3 Receptor System
Status: RECRUITING
Conditions: Opioid Use Disorder
Interventions: DRUG: [11C]-PHNO|DIETARY_SUPPLEMENT: Calcitriol|OTHER: Placebo Control|PROCEDURE: PET Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study to Evaluate the Cardiac Safety of 2 Doses of CHF5993 Both Combined With CHF1535 BID Versus CHF1535 BID in Patients With Moderate to Severe COPD
Status: COMPLETED
Conditions: Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: CHF1535 + CHF5992 dose 1 BID|DRUG: CHF1535 + CHF5992 dose2 BID|DRUG: CHF1535 daily dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase IV Study of the Onset and Maintenance of the Antiplatelet Effect of Ticagrelor Compared With Clopidogrel in Chinese Patients With ACS
Status: COMPLETED
Conditions: Non-ST or ST Elevation Acute Coronary Syndromes
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Enahnced External Counterpulsation to Treat Coronary Heart Disease
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: Enhanced external counterpulsation|DRUG: Guideline-driven standard medical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label, Dose-Escalation/Dose-Expansion Safety Study of INCB059872 in Subjects With Advanced Malignancies
Status: TERMINATED
Conditions: Solid Tumors and Hematologic Malignancy
Interventions: DRUG: INCB059872|DRUG: all-trans retinoic acid (ATRA)|DRUG: azacitidine|DRUG: nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visualization Engineering Platform for Pulse Diagnosis of Traditional Chinese Medicine-The Research of Similar Moiré Feature Analyzing Approach Based on Recurrent Neural Network to Process the Measured Slip Pulse Wave-Images With Chun, Guan and Chy
Status: UNKNOWN
Conditions: Slippery Pulse
Interventions: DIAGNOSTIC_TEST: Recurrent Neural Network
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sustained Effect of Urticaria Remission With Relatively High Dose Vitamin D Supplementation After Omalizumab Discontinuation
Status: WITHDRAWN
Conditions: Urticaria
Interventions: DIETARY_SUPPLEMENT: Vitamin D (4,000 IU/day)|DIETARY_SUPPLEMENT: Vitamin D (400 IU/day)|DRUG: Omalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ISTAPS: A Stepped Primary Care Smoking Cessation Intervention
Status: UNKNOWN
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Advice|BEHAVIORAL: Motivational Interviewing|DRUG: Nicotine Gum and Patch|DRUG: Bupropion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Results of Selective Prostatic Arterial Embolization in Patients With Indwelling Urinary Catheter Due to Benign Prostatic Hyperplasia Refractory to Medical Treatment.
Status: TERMINATED
Conditions: Benign Prostatic Hyperplasia
Interventions: DEVICE: Prostatic arterial embolization using BeadBlock (Terumo)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Use of Brain Activity Monitoring Dynamics in ADHD
Status: COMPLETED
Conditions: ADHD
Interventions: DEVICE: EEG monitoring (MindWave by NeuroSky)|DEVICE: EEG monitoring (EPOC by Emotiv)|DRUG: Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Chimeric Antigen Receptor (CAR) T Cell Therapy With YESCARTA in the Outpatient Setting
Status: ACTIVE_NOT_RECRUITING
Conditions: Large B-cell Lymphoma|Diffuse Large B-cell Lymphoma
Interventions: PROCEDURE: Telemedicine Visit|PROCEDURE: Vital sign measurements|PROCEDURE: Out-Patient Clinic Visit|PROCEDURE: Blood pressure and pulse oximeter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: To Differentiate Focal Autoimmune Pancreatitis From Pancreatic Cancer by Endoscopic Ultrasound
Status: RECRUITING
Conditions: Autoimmune Pancreatitis|Pancreatic Cancer
Interventions: OTHER: Diagnostic imaging modalities for validation sample|OTHER: EUS for derivation sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chemoimmunotherapy and Allogeneic Stem Cell Transplant for NK T-cell Leukemia/Lymphoma
Status: RECRUITING
Conditions: NK-Cell Lymphoma|NK-Cell Leukemia|Peripheral T Cell Lymphoma
Interventions: DRUG: Methotrexate|DRUG: pralatraxate,|DRUG: Ifosfamide|DRUG: Dexamethasone|DRUG: Etoposide|DRUG: calaspargase pegol|DRUG: cyclophosphamide|DRUG: Doxorubicin|DRUG: Prednisone|DRUG: Brentuximab Vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Methods to Reduce Anxiety in Preoperative Elective Surgical Patients
Status: COMPLETED
Conditions: Anxiety
Interventions: DRUG: Midazolam|DRUG: Normal Saline|DEVICE: Bair Hugger
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Tertiary A-level Hospital Remote Intervention on MACCE, Adherence to Drugs and Risk Factors Control in Patients With Stable Coronary Artery Disease Compared With Traditional Community Hospital Follow-up
Status: COMPLETED
Conditions: Stable Chronic Angina|Ischemic Heart Disease|Acute Coronary Syndrome
Interventions: BEHAVIORAL: Intervention|BEHAVIORAL: Control
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pulpal Blood Flow Changes Using SuperElastic 0.018-inch Nickel Titanium
Status: COMPLETED
Conditions: Orthodontic Appliance
Interventions: PROCEDURE: 0.014-inch NiTi on one side /0.018-inch NiTi on the other side|PROCEDURE: 0.016-inch NiTi on one side /0.018-inch NiTi on the other side
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFpEF Patients Treated With Allogeneic CDCs
Status: COMPLETED
Conditions: Congestive Heart Failure|Heart Failure, Diastolic
Interventions: BIOLOGICAL: Allogeneic Derived Cells|BIOLOGICAL: Placebo/Control Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Activated Charcoal and Time of Dose on the Pharmacokinetics of LY2624803 in Healthy Subject
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: LY2624803|OTHER: Activated Charcoal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of MRG003 in the Treatment of Patients With EGFR-positive Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: MRG003+HX008
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incretin Effects of Branched Chain Amino Acids
Status: COMPLETED
Conditions: Glucose Metabolism Disorders
Interventions: DIETARY_SUPPLEMENT: IV BCAA|DIETARY_SUPPLEMENT: ORAL BCAA|OTHER: ORAL Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Everolimus-Eluting Bioresorbable Scaffolds Versus Everolimus-Eluting Metallic Stents for Diffuse Long Coronary Artery Disease
Status: TERMINATED
Conditions: Percutaneous Transluminal Coronary Angioplasty
Interventions: DEVICE: everolimus-eluting bioresorbable vascular (Absorb) scaffold|DEVICE: everolimus-eluting cobalt-chromium (Xience) stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Controlled Ovarian Stimulation in Newly Diagnosed Breast Cancer PatiEnts (fAMHOPE)
Status: RECRUITING
Conditions: Breast Neoplasm Malignant Female
Interventions: DRUG: Letrozole|OTHER: standard-stimulated cohort
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Non-invasive Ventilation in Hypercapnic COPD
Status: TERMINATED
Conditions: Copd|Chronic Obstructive Pulmonary Disease|Hypercapnia|Chronic Respiratory Failure|Hypoventilation
Interventions: DEVICE: High-intensity non-invasive ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CES1 Carriers in the PAPI Study
Status: COMPLETED
Conditions: Heart Diseases|Coronary Disease|Coronary Artery Disease|Cardiovascular Diseases|Myocardial Ischemia|Artery Occlusion|Aspirin Sensitivity|Clopidogrel, Poor Metabolism of|Platelet Dysfunction|Platelet Thrombus
Interventions: DRUG: Clopidogrel|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: ARMONIA: An Observational Study of Biologic Drugs in Monotherapy or Combination With DMARDs in Italian Clinical Practice and the Efficacy and Safety of RoActemra/Actemra (Tocilizumab) Monotherapy in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Antitussive Effect of Single-dose Dexmedetomidine With Low-dose Remifentanil Infusion
Status: COMPLETED
Conditions: Thyroidectomy
Interventions: DRUG: Dexmedetomidine + Remifentanil-low dose|DRUG: Remifentanil-high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Enzalutamide and Indomethacin in Treating Patients With Recurrent or Metastatic Hormone-Resistant Prostate Cancer
Status: RECRUITING
Conditions: Metastatic Prostate Carcinoma|Recurrent Prostate Carcinoma|Stage IV Prostate Cancer
Interventions: DRUG: Enzalutamide|DRUG: Indomethacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0307 Phase III Trial of Bisphosphonates as Adjuvant Therapy for Primary Breast Cancer.
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: clodronate disodium|DRUG: ibandronate sodium|DRUG: zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bowel Care and Cardiovascular Function After Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: DRUG: Lidocaine lubricant|OTHER: Placebo lubricant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cilostazol and Nimodipine Combined Therapy After Aneurysmal Subarachnoid Hemorrhage (aSAH)
Status: TERMINATED
Conditions: Aneurysmal Subarachnoid Hemorrhage
Interventions: DRUG: Cilostazol 100 MG|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Will the Use of Triesence During Glaucoma Surgery Provide Lower Eye Pressure and Improve the Results of the Surgery?
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: Triesence|DRUG: balanced salt solution BSS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count
Status: COMPLETED
Conditions: Bone Marrow Suppression|Fever, Sweats, and Hot Flashes|Infection|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Unspecified Adult Solid Tumor, Protocol Specific|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: piperacillin sodium|DRUG: piperacillin-tazobactam|DRUG: tazobactam sodium|DRUG: vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Circulating Tumor DNA-guided Neoadjuvant Treatment Strategy for Locally Advanced Rectal Cancer
Status: RECRUITING
Conditions: Locally Advanced Rectal Carcinoma|Circulating Tumor DNA
Interventions: OTHER: circulating tumor DNA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of SAR302503 on ECG Activity in Patients With Solid Tumors
Status: COMPLETED
Conditions: Neoplasm Malignant
Interventions: DRUG: SAR302503 (TG101348)|DRUG: Placebo SAR302503|DRUG: Panolosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Uproleselan, Azacitidine, and Venetoclax for the Treatment of Treatment Naive Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|DRUG: Uproleselan|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diclofenac Patch for Treatment of Mild to Moderate Ankle Sprain
Status: TERMINATED
Conditions: Ankle Sprain
Interventions: DRUG: diclofenac sodium|DRUG: Matching placebo patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DEB ( Drug Eluting Balloon) in Crural Arteries and Critical Limb Ischemia
Status: COMPLETED
Conditions: Peripheral Vascular Diseases
Interventions: DEVICE: DEB|DEVICE: POBA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Adult Volunteers to Assess the Safety and Pharmacokinetics of an Investigational Imaging Product
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: ASP5354|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Simplified Strategy for the Long-term Management of HIV Infection (Simpl'HIV)
Status: COMPLETED
Conditions: HIV-1-infection|Antiretroviral Therapy|Maintenance Therapy
Interventions: DRUG: Switch to DTG + FTC|OTHER: Patient-centered monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label, Phase II Trial of Isatuximab for Patients With Refractory Immune Cytopenias After Allogeneic Hematopoietic Cell Transplantation
Status: RECRUITING
Conditions: Blood Cancer|Refractory Immune Cytopenias
Interventions: BIOLOGICAL: Isatuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Fluconazole and Amphotericin B in the Treatment of Cryptococcal Meningitis
Status: COMPLETED
Conditions: Meningitis, Cryptococcal|HIV Infections
Interventions: DRUG: Flucytosine|DRUG: Fluconazole|DRUG: Amphotericin B
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effect of Kinesio Taping® on Motor Control in Patients With Patellofemoral Pain Syndrome
Status: COMPLETED
Conditions: Knee Injuries|Pain Syndrome
Interventions: OTHER: Application of Kinesio Taping®|OTHER: Kinesio Taping® placebo application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quadratus Lumborum Block III Versus Peritubal Local Infiltration
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Quadratus block versus peritubal local infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Blood Loss During Cesarean Delivery in Placenta Previa Patients
Status: COMPLETED
Conditions: Placenta Previa
Interventions: DRUG: Tranexamic acid|DRUG: Misoprostol|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Adjuvant ONO-4538 With Resected Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: Nivolumab|DRUG: Tegafur-gimeracil-oteracil potassium|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lidocaine, Povidone Iodine, and Honey Application on Second-degree Perineal Tear Healing
Status: COMPLETED
Conditions: Perineal Tear
Interventions: DRUG: honey|DRUG: lidocaine|DRUG: povidone-iodine|OTHER: control groups
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality (VR) Diagnostic Tool for Attention Deficits/Hyperactivity Disorder (ADHD)
Status: UNKNOWN
Conditions: ADHD|Executive Dysfunction
Interventions: DEVICE: ADHD-VR diagnosis tool
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial of Positive Deviance in Inpatient Wards to Reduce Hospital Infections
Status: COMPLETED
Conditions: Healthcare-associated Infections
Interventions: BEHAVIORAL: Positive Deviance|OTHER: Standard-of-Care Infection Control approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Sildenafil in Heart Failure With Reactive Pulmonary Hypertension
Status: TERMINATED
Conditions: Heart Failure With Reactive Pulmonary Hypertension
Interventions: DRUG: Sildenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety, Tolerability, and Efficacy of GS-9674 in Participants With Nonalcoholic Steatohepatitis (NASH)
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis (NASH)
Interventions: DRUG: GS-9674|DRUG: Placebo to match GS-9674
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Memory Aid - Working Memory Training in Patients With Mild Cognitive Impairment.
Status: UNKNOWN
Conditions: Mild Cognitive Impairment
Interventions: DEVICE: Computerized Working Memory Training.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Rencofilstat in Adult Subjects With NASH F3
Status: COMPLETED
Conditions: NASH With Fibrosis
Interventions: DRUG: rencofilstat, 75 mg|DRUG: rencofilstat, 150mg|DRUG: rencofilstat, 225 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Calcineurin Inhibitor Free GvHD Prophylaxis in Allogeneic Stem Cell Transplantation
Status: UNKNOWN
Conditions: Hematologic Diseases
Interventions: DRUG: Everolimus and mycophenolate sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Adaptive Servoventilation on Cardiac Function in Chronic Heart Failure and Cheyne-Stokes Respiration
Status: UNKNOWN
Conditions: Chronic Heart Failure|Central Sleep Apnea|Cheyne-Stokes Respiration
Interventions: DEVICE: Adaptive servoventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Akt Inhibitor MK2206 in Combination With Lapatinib Ditosylate in Patients With Advanced or Metastatic Solid Tumors or Breast Cancer
Status: COMPLETED
Conditions: HER2-positive Breast Cancer|Male Breast Cancer|Recurrent Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: Akt inhibitor MK2206|DRUG: lapatinib ditosylate|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Vignette-based Randomized Controlled Trial to Evaluate the Impact of Research Climate on Research Practices of Doctoral Students
Status: UNKNOWN
Conditions: The Study Focus on no Specific Condition
Interventions: OTHER: Vignette with emphasis on research climate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Efficacy of Tongue Exercises on Swallowing Function in the Elderly With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Dysphagia, Oropharyngeal
Interventions: OTHER: tongue resistance exercises, tongue strengthening exercises and tongue resistance exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Nebulised BromAc in Healthy Volunteers
Status: COMPLETED
Conditions: COVID-19 Pneumonia|Bromelains Adverse Reaction|Acetylcysteine Adverse Reaction|Mucus; Plug|COVID-19 Acute Respiratory Distress Syndrome
Interventions: DRUG: BromAc
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT