pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Phase 1/2 Study of High-dose Genetically Targeted Enzyme Replacement Therapy for Advanced Heart Failure
Status: TERMINATED
Conditions: Ischemic Cardiomyopathy|Non-ischemic Cardiomyopathy|Heart Failure|Cardiomyopathies
Interventions: GENETIC: MYDICAR Phase 1|GENETIC: MYDICAR Phase 2|GENETIC: Placebo Phase 2 only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy Targeted Against Cytomegalovirus in Patients With Newly-Diagnosed WHO Grade IV Unmethylated Glioma
Status: TERMINATED
Conditions: Glioblastoma
Interventions: BIOLOGICAL: Human CMV pp65-LAMP mRNA-pulsed autologous DCs containing GM CSF|DRUG: Temozolomide|BIOLOGICAL: Tetanus-Diphtheria Toxoid (Td)|BIOLOGICAL: GM-CSF|BIOLOGICAL: 111-Indium-labeling of Cells for in vivo Trafficking Studies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Synovial Biopsies in Predicting Response to Biologic Therapy in Rheumatoid Arthritis Patients
Status: WITHDRAWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Anti-TNF|DRUG: JAK inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Acamprosate for Treatment of Methamphetamine Addiction
Status: COMPLETED
Conditions: Methamphetamine Dependence, Treatment Seeking
Interventions: DRUG: Acamprosate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Managing Chronic Tendon Pain by Metformin
Status: RECRUITING
Conditions: Tendinopathy|Chronic Pain|Achilles Tendinopathy
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-Guided Microendoscopic Versus Fluoroscopic-Guided Lumbar Transforaminal Epidural Steroid Injections
Status: NOT_YET_RECRUITING
Conditions: Radiculopathy Lumbar|Disc Disease Lumbar
Interventions: DEVICE: Ultrasound microendoscopic technique|RADIATION: Fluoroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Vinblastine in Combination With Nilotinib in Children, Adolescents, and Young Adults
Status: TERMINATED
Conditions: Refractory Low-grade Gliomas|Recurrent Low-grade Gliomas
Interventions: DRUG: Vinblastine + Nilotinib|DRUG: Vinblastine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In-Vivo Bleeding Volume Test for Platelet-Aspirin Interaction
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: Aspirin ingestion followed by doing a Bleeding Volume Test|PROCEDURE: Gatorade Placebo followed by Bleeding Volume Test.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: APG-1387 Study of Safety, Tolerability ,PK/PD in Patients With Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: APG-1387 for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Caregiver Training on DTTC Treatment Outcomes in CAS
Status: RECRUITING
Conditions: Childhood Apraxia of Speech
Interventions: BEHAVIORAL: Dynamic Temporal and Tactile Cueing (DTTC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Screening for Metabolic Problems in Mothers of Children With Autism and Typically Developing Children
Status: COMPLETED
Conditions: Pregnancy|Autistic Disorder|Folic Acid Deficiency
Interventions: DIETARY_SUPPLEMENT: Prenatal supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Testing JNJ-42756493 (Erdafitinib) as Potentially Targeting Treatment in Cancers With FGFR Amplifications (MATCH-Subprotocol K1)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lymphoma|Advanced Malignant Solid Neoplasm|Refractory Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Multiple Myeloma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Erdafitinib|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Magnetic Stimulation in the Treatment of Female UUI.
Status: RECRUITING
Conditions: Urinary Incontinence|Urinary Incontinence, Urge|Pelvic Floor Disorders
Interventions: DEVICE: Extracorporeal magnetic stimulation|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sunitinib, Cyclophosphamide, and Methotrexate in Treating Patients With Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: methotrexate|DRUG: sunitinib malate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel Eluting Stent in Long SFA Obstruction: A Prospective, Randomized Comparison With Bypass Surgery
Status: RECRUITING
Conditions: Chronic Lower Limb Ischemia|Peripheral Athero Obstructive Disease|Critical Ischemia|Claudication
Interventions: PROCEDURE: bypass surgery, stent placement|PROCEDURE: stent placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Organ Protection With Sevoflurane Postconditioning After Cardiac Surgery With Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Cardiac On-pump Surgery
Interventions: DRUG: Sevoflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Vaccination With Autologous Acute Myeloblastic Leukemia Cells in Patients With Advanced Myelodysplasia or Acute Myelogenous Leukemia
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Myelodysplasia
Interventions: BIOLOGICAL: autologous tumor cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: GSP as an Novel Indicator for Residual Liver Function in Patients With Fatty Liver
Status: COMPLETED
Conditions: Galactose Single Point (GSP), Residual Liver Function
Interventions: DRUG: Drug: G.S.P. Solution 400 mg/ml I.V. 1.25 ml/kg BW G.S.P. solution after fasting for 6 hours.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study to Evaluate Vadadustat for Anemia in Subjects With Dialysis-Dependent Chronic Kidney Disease (DD-CKD) Who Are Hyporesponsive to Erythropoiesis Stimulating Agents
Status: TERMINATED
Conditions: Anemia|Dialysis-Dependent Chronic Kidney Disease
Interventions: DRUG: vadadustat|DRUG: epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation of an Integrated System of Artificial Intelligence and Referral Tracking for Real-time Diabetic Retinopathy Screening
Status: UNKNOWN
Conditions: Diabetic Retinopathy|Artificial Intelligence|Screening
Interventions: DIAGNOSTIC_TEST: Artificial Intelligence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Pharmacokinetics of Leritrelvir(RAY1216) in Participants With Severe Kidney Disease
Status: COMPLETED
Conditions: Kidney Impairment
Interventions: DRUG: Leritrelvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Glucose Intolerance and Diabetes Related to Treatment With Steroids and PEG- Asparaginase in Children and Adolescents With ALL and Lymphoma
Status: RECRUITING
Conditions: Precursor Cell Lymphoblastic Leukemia-Lymphoma|Drug-Induced Diabetes Mellitus|Impaired Glucose Tolerance|Lymphoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 1 Safety Study of Encorafenib in Chinese Patients With Advanced Metastatic BRAF V600E Mutant Solid Tumors
Status: COMPLETED
Conditions: BRAF V600E Unresectable or Metastatic Melanoma|BRAF V600E Metastatic NSCLC|Melanoma
Interventions: DRUG: Encorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Compare the Effects of Either Telmisartan (40-80 mg PO Once Daily) or Ramipril (5-10 mg PO Once Daily) on Renal Endothelial Dysfunction in Hypertensive Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Hypertension
Interventions: DRUG: Telmisartan|DRUG: Ramipril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Patching and Interactive Binocular Treatment (IBiTTM) in Amblyopia
Status: UNKNOWN
Conditions: The New Treatment in Amblyopia Therapy
Interventions: DEVICE: Interactive Binocular Treatment|PROCEDURE: Patching Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: S1403, Afatinib Dimaleate With or Without Cetuximab in Treating Patients With Newly Diagnosed Stage IV or Recurrent, EGFR Mutation Positive Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Non-Small Cell Lung Carcinoma|Stage IV Non-Small Cell Lung Cancer
Interventions: DRUG: Afatinib Dimaleate|BIOLOGICAL: Cetuximab|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development, Implementation and Evaluation of the Impact of a Guideline in Clinical Practise for Cardiovascular Risk
Status: COMPLETED
Conditions: Cardiovascular Risk Factors|Clinical Practice Guideline|Implementation Strategies|Primary Care
Interventions: OTHER: Implementation|OTHER: dissemination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cannabidiol for Inflammatory Bowel Disease
Status: COMPLETED
Conditions: Crohn's Disease|Ulcerative Colitis
Interventions: DRUG: cannabidiol|DRUG: placebo in drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Volunteers to Assess Effect of AZD6765 on Midazolam Blood Levels
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD6765|DRUG: midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Assess the Immune Response Following Primary Vaccination With GSK Biologicals' Tritanrix™-HepB/Hib-MenAC vs Tritanrix™-HepB/Hiberix™ Given at 6,10 & 14 Wks of Age to Infants Who Received Hepatitis B Vaccine at Birth
Status: COMPLETED
Conditions: Diphtheria; Haemophilus Influenzae Type b; Hepatitis B; Tetanus; Whole Cell Pertussis
Interventions: BIOLOGICAL: DTPw-HBV/Hib-MenAC conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: APIXABAN in the Prevention of Stroke and Systemic Embolism in Patients With Atrial Fibrillation in Real-Life Setting in France SNIIRAM Study
Status: COMPLETED
Conditions: Anticoagulation
Interventions: DRUG: VKA|DRUG: Apixaban|DRUG: dabigatran|DRUG: rivaroxaban
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Compare the Effect of Hormone Replacement Therapy (HRT) on Breast and Cardiovascular Metabolic Markers in Postmenopausal Women
Status: COMPLETED
Conditions: Menopause
Interventions: DRUG: 17ß-Estradiol/Dydrogesterone|DRUG: Tibolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Natural Killer (NK) Cells in Combination With Interleukin-2 (IL-2) and Transforming Growth Factor Beta (TGFbeta) Receptor I Inhibitor Vactosertib in Cancer
Status: RECRUITING
Conditions: Colorectal Cancer|Hematologic Malignancy|Rectum Cancer|Acute Myeloid Leukemia|Myelodysplastic Syndromes|Acute Lymphoblastic Leukemia|Chronic Myeloid Leukemia|Chronic Lymphocytic Leukemia|Hodgkin Lymphoma|Non Hodgkin Lymphoma|Myeloproliferative Syndrome|Plasma Cell Myeloma
Interventions: DRUG: Vactosertib|DRUG: Fludarabine Phosphate|DRUG: Cyclophosphamide|DRUG: IL-2|DRUG: Natural Killer Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study on the Transfer of Adenovirus With the CD40 Ligand Gene (AdcuCD40L) to Patients With Esophageal Carcinoma
Status: WITHDRAWN
Conditions: Esophageal Neoplasms
Interventions: GENETIC: AdcuCD40L|GENETIC: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Analysis of Risk Factors and Prediction of Frailty Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Frail Elderly Syndrome
Interventions: DIAGNOSTIC_TEST: Frail scale|DIAGNOSTIC_TEST: Barthel scale|DIAGNOSTIC_TEST: SARC-F|DIAGNOSTIC_TEST: FRAX|DIAGNOSTIC_TEST: Mini-Cog scale|DIAGNOSTIC_TEST: dynamometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: DLBS1442 for The Treatment of Pain in Patients Suspected Endometriosis
Status: COMPLETED
Conditions: Endometrioma|Visual Analogue Pain Scale: Moderate or Severe Pain
Interventions: DRUG: DLBS1442 100|DRUG: Mefenamic acid|DRUG: DLBS1442 200
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Adaptive Dosing of Ipilimumab and Nivolumab Combination Immunotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Melanoma
Interventions: DRUG: ipilimumab|DRUG: nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Montelukast in Preventing Dengue With Warning Signs in Dengue Patients
Status: COMPLETED
Conditions: Dengue|Dengue With Warning Signs|Dengue Shock Syndrome
Interventions: DRUG: Montelukast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pegylated Interferon Alone in Egyptian Patients With Acute Hepatitis C (ANRS 1213)
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: pegylated interferon alpha2a
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Bright Light Therapy for Opioid Use Disorder
Status: RECRUITING
Conditions: Opioid Use Disorder|Sleep Disturbance
Interventions: DEVICE: Wearable bright light therapy device|DEVICE: Wearable placebo light therapy device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Nasal Epinephrine
Status: COMPLETED
Conditions: Anaphylaxis
Interventions: DRUG: Epinephrine Nasal Product, 1.6 mg|DRUG: Epinephrine nasal product, 1.6 mg + allergen|DRUG: Epinephrine Injection 0.3 mg|DRUG: Epinephrine Nasal Product, 3.2 mg|DRUG: Epinephrine Nasal Product, 3.2 mg + allergen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Class II Malocclusion With Excessive Overjet
Status: ACTIVE_NOT_RECRUITING
Conditions: Class II Malocclusion, Division 1|Orthodontic Appliances|Quality of Life|Costs and Cost Analysis
Interventions: DEVICE: HGA|DEVICE: FA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility of MR-guided Laser Thermal Ablation of Brain Lesions
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma
Interventions: DEVICE: TRANBERG® laser applicators when used in MR-guided laser thermal ablation of brain lesions using the TRANBERG® Thermal Therapy System and TRANBERG® Thermoguide Workstation.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: The Effect of Ketamine on the Length of Hospital Stay of Patients Hospitalized With Suicidal Ideation.
Status: TERMINATED
Conditions: Suicidal Ideation
Interventions: DRUG: Ketamine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness Self-Compassion Intervention Versus a Cognitive-Behavioral Intervention to Improve Self-care in Chronic Pain
Status: COMPLETED
Conditions: Chronic Pain
Interventions: BEHAVIORAL: MSC|BEHAVIORAL: CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of LY450139 Dihydrate on Subjects With Mild to Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: LY450139 dihydrate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study Comparing a New Dosing Regimen of Clot-dissolving Drug for Mechanical Heart Valves Which Show Clots
Status: COMPLETED
Conditions: Prosthetic Valve Thrombosis
Interventions: DRUG: Streptokinase|DRUG: Streptokinase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Trendelenburg Position and Passive Leg Lift on Hemodynamics in Abdominal Surgery Patients
Status: UNKNOWN
Conditions: The Angle of Trendelenburg
Interventions: OTHER: Trendeleburg -5 degree,-10 degree,-15 degree
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Guanfacine Attenuate Stress-Induced Drinking?
Status: COMPLETED
Conditions: Alcohol Drinking
Interventions: DRUG: Guanfacine 3mg/day|DRUG: Guanfacine 1.5mg/day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Risser Stage on Pressure of Correction in Pectus Carinatum
Status: UNKNOWN
Conditions: Pectus Carinatum
Interventions: OTHER: Tanner stage|OTHER: Risser stage|OTHER: Pressure of correction|OTHER: Pectus carinatum protrusion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Website Application Based Education and Text Messaging in Improving Skin Wound Care in Patients Undergoing Mohs Surgery
Status: COMPLETED
Conditions: Malignant Skin Neoplasm
Interventions: PROCEDURE: Mohs Surgery|OTHER: Internet-Based Intervention|BEHAVIORAL: Telephone-Based Intervention|OTHER: Educational Intervention|BEHAVIORAL: Exercise Intervention|OTHER: Petrolatum-Mineral Oil-Lanolin-Ceresin Ointment|OTHER: Questionnaire Administration|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study of Patellar Resurfacing and Non-resurfacing in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Total Knee Arthroplasty
Interventions: PROCEDURE: the patella was resurfaced.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Family-based Childhood Behavior Intervention to Decrease Environmental Melamine and Phthalate Exposure
Status: COMPLETED
Conditions: Healthy Children and Their Main-care Giver
Interventions: BEHAVIORAL: Assigned intervention|BEHAVIORAL: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Perioperative Mechanical Ventilation and Postoperative Monitoring of IPI
Status: COMPLETED
Conditions: Mechanical Ventilation Complication|Postoperative Pulmonary Atelectasis
Interventions: DEVICE: INTELLiVENT-ASV mode|DEVICE: SIMV mode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Trial to Alleviate Malnutrition With Fortified Spread Given as a Food Supplement to Underweight Infants
Status: COMPLETED
Conditions: Malnutrition
Interventions: PROCEDURE: Food supplement: fortified spread|PROCEDURE: Food supplement: maize and soy flour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Sarpogrelate on Blood Hyperviscosity
Status: COMPLETED
Conditions: Peripheral Artery Disease, PAD
Interventions: DRUG: Anplag Tab. 100mg bid|DRUG: Anplag Tab. 100mg tid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Disease|Coronary Artery Disease|Heart Diseases|Myocardial Ischemia
Interventions: PROCEDURE: cardiac catheterization|PROCEDURE: coronary artery bypass graft surgery|PROCEDURE: percutaneous coronary intervention|BEHAVIORAL: Lifestyle|DRUG: Medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Vision Patients' Preference for Colored Filters and Illumination for Near Reading Determined by the LuxIQ/2
Status: COMPLETED
Conditions: Ocular Conditions Resulting in Visual Impairment
Interventions: DEVICE: Colored near reading glasses|DEVICE: Lighting as determined by LuxIQ/2 or OttLite Cobra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Leptin A-200, Caffeine/Ephedrine and Their Combination Upon Weight Loss and Body Composition in Man
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: caffeine and ephedrine|DRUG: Leptin A|DRUG: caffeine, ephedrine, and leptin A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Intrastromal Correction of Ametropia by a Femtosecond Laser
Status: UNKNOWN
Conditions: Presbyopia|Myopia|Hyperopia|Astigmatism
Interventions: DEVICE: Intrastromal Correction of Presbyopia|DEVICE: Intrastromal correction of Myopia|DEVICE: Intrastromal Correction of Hyperopia|DEVICE: Intrastromal Correction of Myopia incl. Astigmatism|DEVICE: Intrastromal Correction of Hyperopia incl. Astigmatism
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of the Use of a Carnitine-Orotate Complex and Biphenyl Dimethyl Dicarboxylate in the Pathogenetic Therapy of Metabolic-associated Fatty Liver Disease: a Prospective Cohort Study
Status: RECRUITING
Conditions: Metabolic-associated Fatty Liver Disease (MAFLD)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Efficacy and Safety of Mongersen (GED-0301) for the Treatment of Adult and Adolescent Subjects With Active Crohn's Disease
Status: WITHDRAWN
Conditions: Crohn Disease
Interventions: DRUG: GED-0301|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vargatef in Addition to First Line Chemotherapy With Interval Debulking Surgery in Patients With Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: vargatef|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Smoking Cessation After Acute Coronary Syndrome
Status: COMPLETED
Conditions: Smoking|Acute Coronary Syndrome|Recurrence
Interventions: PROCEDURE: Nicotine replacement therapy delivred in cardiology intensive care unit versus Nicotine replacement therapy delivered after hospital discharge|DRUG: Nicotine patch|OTHER: the external consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Pharmacology Trial of Calcium-vitamin D3 Tablet in Healthy Participants
Status: COMPLETED
Conditions: Calcium Deficiency|Vitamin D Deficiency
Interventions: DRUG: Calcium 500 mg and Vitamin D3 800 IU|OTHER: Low calcium meals
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of EMD Protocol for Urge on Dermatology-specific Quality of Life
Status: RECRUITING
Conditions: Atopic Dermatitis|Prurigo Nodularis
Interventions: BEHAVIORAL: EMD Protocol for Urge|OTHER: Care as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Co-administration of Propofol and Remifentanil for Lumbar Puncture in Children
Status: COMPLETED
Conditions: Spinal Puncture
Interventions: DRUG: Propofol 2.0 mg/kg + Remifentanil 1.5 ug/kg|DRUG: Propofol 4.0 mg/kg + Remifentanil 0.5 ug/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Routine Versus Selective Intraoperative ECMO in Lung Transplant
Status: COMPLETED
Conditions: Lung Transplant; Complications|Extracorporeal Circulation; Complications|Postoperative Complications
Interventions: DEVICE: Routine ECMO|DEVICE: On demand ECMO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Brentuximab Vedotin + Adriamycin, Vinblastine, and Dacarbazine in Pediatric Participants With Advanced Stage Newly Diagnosed Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Hodgkin Disease
Interventions: DRUG: Brentuximab vedotin|DRUG: Doxorubicin|DRUG: Vinblastine|DRUG: Dacarbazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Erector Spinae Block on Diaphragma Movement
Status: COMPLETED
Conditions: Laparoscopic Cholecystectomy|Acute Post-operative Pain|Respiratory Diaphragm
Interventions: PROCEDURE: Erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION