pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Post-Authorization Safety Study (PASS) of LysaKare® in Adult Gastroenteropancreatic Neuroendocrine Tumor (GEP-NET) Patients
Status: COMPLETED
Conditions: Gastroenteropancreatic Neuroendocrine Tumors
Interventions: DRUG: arginine/lysine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Estrogen and Methyltestosterone Combination Treatments for Postmenopausal Hot Flushes
Status: COMPLETED
Conditions: Hot Flushes, Menopause, Postmenopause
Interventions: DRUG: Esterified Estrogens (EE) and Methyltestosterone (MT)|DRUG: Esterified Estrogens (EE) and Methyltestosterone (MT)|DRUG: Esterified Estrogens (EE) and Methyltestosterone (MT)|DRUG: Esterified Estrogens (EE) and Methyltestosterone (MT)|DRUG: Esterified Estrogens (EE) and Methyltestosterone (MT)|DRUG: Esterified Estrogens (EE) and Methyltestosterone (MT)|DRUG: Esterified Estrogens (EE) and Methyltestosterone (MT)|DRUG: Esterified Estrogens (EE) and Methyltestosterone (MT)|DRUG: Esterified Estrogens (EE) and Methyltestosterone (MT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotic Supplement Versus Placebo for the Treatment of Patients With Non-alcoholic Fatty Liver Disease
Status: RECRUITING
Conditions: Fatty Liver, Nonalcoholic
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Fecal Incontinence and Chronic Constipation With Low-volume Irrigation
Status: NOT_YET_RECRUITING
Conditions: Constipation|Fecal Incontinence
Interventions: DEVICE: Low-volume irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of an Investigational Regimen Combining FDA Approved HIV Drugs in HIV-Infected Subjects
Status: COMPLETED
Conditions: HIV Infection|Infection, Human Immunodeficiency Virus
Interventions: DRUG: Half-boosted Fosamprenavir|DRUG: Full Boosted Fosamprenavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigational Drug Versus an Approved Drug in Patients With Rheumatoid Arthritis (0663-072)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: MK0663, etoricoxib|DRUG: Comparator: Diclofenac sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Dutasteride on Androgen-Response Gene Expression in Patients With Advanced Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Dutasteride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Nutropin AQ for the Treatment of Growth Restriction in Children With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Nutropin AQ [somatropin (DNA origin) injection]
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Combined MEK, STAT3 and PD-1 Inhibition in Metastatic Pancreatic Ductal Adenocarcinoma
Status: RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: Trametinib|DRUG: Ruxolitinib|DRUG: Retifanlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of the Safety and Pharmacokinetics of Recombinant CD4 Immunoglobulin G (rCD4-IgG) in HIV-1 Seropositive Women During the Last Trimester of Pregnancy and Their Newborns
Status: COMPLETED
Conditions: HIV Infections|Pregnancy
Interventions: DRUG: CD4-IgG
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Single Dose Study of the Pharmacokinetics of Vibegron (MK-4618) in Participants With Renal Insufficiency (MK-4618-014)
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: Vibegron 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Family Focused Treatment of Pediatric Obsessive Compulsive Disorder
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: BEHAVIORAL: Individual Child CBT|BEHAVIORAL: Positive Family Interaction Therapy|BEHAVIORAL: Positive Family Interaction Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Bifidobacterium Longum BB536 on Incidence of Acute Diarrhea and/or Respiratory- Related Illnesses in Children
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: BB536|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study About the Long-Term Safety of TAK-881 in People With Primary Immunodeficiency Diseases
Status: NOT_YET_RECRUITING
Conditions: Primary Immunodeficiency Diseases (PID)
Interventions: BIOLOGICAL: TAK-881|DEVICE: SC Investigational Needle Sets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Nicotinamide Riboside and Pterostilbene Supplementation on Muscle Regeneration in Elderly Humans
Status: COMPLETED
Conditions: Muscle Injury
Interventions: OTHER: Placebo (twice daily)|OTHER: Nicotinamide Riboside/Pterostilbene (500 mg/100 mg twice daily)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nutrition on Bone Metabolism as Assessed by 41Ca
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DIETARY_SUPPLEMENT: vitamin K|DIETARY_SUPPLEMENT: calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Tegoprazan on Pharmacodynamics of Clopidogrel in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Clopidogrel 75 mg|DRUG: Tegoprazan 50 mg|DRUG: Esomeprazole 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Profile of Breast Cancer in Ugandan Patients With Stage IIB-III Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer Female|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Invasive Breast Carcinoma|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8
Interventions: DRUG: Cyclophosphamide|DRUG: Methotrexate|DRUG: Capecitabine|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genicular Radiofrequency Ablation for Unilateral Knee Arthroplasty Pain Management
Status: UNKNOWN
Conditions: Osteoarthritis of the Knee
Interventions: PROCEDURE: t-RFA|PROCEDURE: C-RFA|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Atrial Fibrillation Follow-up Investigation to Recover Memory and learnING Trial
Status: COMPLETED
Conditions: Cognitive Impairment|Atrial Fibrillation
Interventions: BEHAVIORAL: cognitive training|BEHAVIORAL: active control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A PMCF Study Confirm the Performance and Safety of the TufTex Over-the-Wire (OTW) Embolectomy Catheters
Status: RECRUITING
Conditions: Thrombus|Embolus|Occlusion; Vessel
Interventions: DEVICE: TufTex Over-the-Wire Embolectomy Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of Single And Ten Day Repeat Atopical Applications Of GW842470X Cream On The Skin Of Patients With Atopic Dermatitis
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: GW842470X|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of the Protective Effect of an Injectable Influenza Vaccine Against Influenza Illness in Adults Under 50 y.o.
Status: UNKNOWN
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza virus vaccine (Fluviral)|BIOLOGICAL: Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: ECT
Clinical trial: GORE® TAG® Thoracic Endoprosthesis French Mandatory Registry
Status: COMPLETED
Conditions: Aortic Aneurysm, Thoracic|Descending Thoracic Aortic Dissection|Aortic Diseases|Aorta Thoracic; Traumatic Rupture|Penetrating Ulcer
Interventions: DEVICE: GORE® TAG® Thoracic Endoprostheses
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess the Efficacy and Safety of Monthly Octreotide Intramuscular Injections in Patients With Proliferative Diabetic Retinopathy After Lasercoagulation This Study is Not Being Conducted in the United States.
Status: TERMINATED
Conditions: Proliferative Diabetic Retinopathy
Interventions: DRUG: Octreotide, 30 mg i.m. LAR formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spinal Morphine Provides an Effective Pain Control in Patients Undergoing Transurethral Resection of Prostate Gland
Status: COMPLETED
Conditions: Spinal Anesthesia|Transurethral Resection of Prostate|Analgesia
Interventions: DRUG: Morphine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase II Study of Gleevec and Arsenic Trioxide in Patients With CML Who Fail Gleevec
Status: COMPLETED
Conditions: Leukemia, Other|Cancer
Interventions: DRUG: Gleevec and Arsenic Trioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predisposing Factors for Chronic Postherniotomy Pain
Status: COMPLETED
Conditions: Chronic Postherniotomy Pain
Interventions: PROCEDURE: Open sutured mesh repair|PROCEDURE: Laparoscopic mesh glue fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Test Different Doses of BI 1701963 in Combination With Irinotecan in People With Advanced Bowel Cancer With Kirsten Rat Sarcoma Viral Oncogene Homologue (KRAS) Mutation
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer (CRC)
Interventions: DRUG: BI 1701963|DRUG: Camptosar®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Chronic Renal Failure With Adipose Tissue-derived Mesenchymal Stem Cells
Status: UNKNOWN
Conditions: Mesenchymal Stem Cells|Chronic Kidney Diseases|Renal Interstitial Fibrosis
Interventions: DRUG: Treatment group|DRUG: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Long-term Evaluation of the Efficacy and Safety of Calistar S for Transvaginal Pelvic Organ Prolapse Repair
Status: RECRUITING
Conditions: Pelvic Organ Prolapse
Interventions: DEVICE: Transvaginal mesh for anterior pelvic organ prolapse repair
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of AlloVax(TM) in Patients With Metastatic or Recurrent Cancer of the Head and Neck
Status: COMPLETED
Conditions: Cancer of Head and Neck|Squamous Cell Carcinoma of the Head and Neck
Interventions: BIOLOGICAL: AlloVax|BIOLOGICAL: CRCL|BIOLOGICAL: AlloStim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study HZA106829: Efficacy/Safety Study of Fluticasone Furoate/Vilanterol (GW642444) in Adult and Adolescent Asthmatics
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone Furoate/Vilanterol Inhalation Powder|DRUG: Fluticasone Furoate Inhalation Powder|DRUG: Fluticasone Propionate Inhalation Powder|OTHER: Placebo Inhalation Powder 1|OTHER: Placebo Inhalation Powder 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive Therapy
Status: COMPLETED
Conditions: Depressive Disorder
Interventions: DRUG: Ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the GTX™ 5126 DES Coronary Stent System in the Treatment of Patients With a Lesion in the Coronary Artery
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: DEVICE: GTX™ Drug Eluting Coronary Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study In Severe Aplastic Anemia Patients Receiving Atg, Cyclosporin A, With Or Without G-CSF (SAA-G-CSF)
Status: TERMINATED
Conditions: Aplastic Anaemia
Interventions: DRUG: G-CSF|DRUG: Early retreatment with ATG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Atezolizumab (an Engineered Anti-Programmed Death-Ligand 1 [PD-L1] Antibody) as Monotherapy or in Combination With Bevacizumab (Avastin®) Compared to Sunitinib (Sutent®) in Participants With Untreated Advanced Renal Cell Carcinoma
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Atezolizumab (MPDL3280A), an Engineered Anti-PD-L1 Antibody|DRUG: Bevacizumab|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Comparison of Patient-specific 3D Printed Splints Versus Conventional Splints in the Treatment of Distal Radius Fractures.
Status: NOT_YET_RECRUITING
Conditions: Distal Radius Fractures
Interventions: DEVICE: 3DxSPLINT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Zoledronic Acid in the Prevention or Delaying of Bone Metastasis in Patients With Stage IIIA and IIIB Non-small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-Small-Cell Lung Cancer
Interventions: DRUG: Zoledronic acid 4 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nitrite Infusion in Islet Cell Transplantation
Status: TERMINATED
Conditions: Diabetes
Interventions: OTHER: Control|DRUG: Pre-Isolation Infusion|DRUG: Post-Isolation Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Adherence Study in COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD
Interventions: DEVICE: Arm 1: BreatheMate device with application|DEVICE: Arm 2: BreatheMate device without application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Mixed Natural Prebiotic-Fibers Impact on Stool Frequency and Fecal Microbiota in Constipated Thai Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Constipation
Interventions: DIETARY_SUPPLEMENT: Haruna|DIETARY_SUPPLEMENT: Placebo Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: GrandAides; a Workforce Innovation to Address Post Acute Care
Status: COMPLETED
Conditions: Heart Failure
Interventions: BEHAVIORAL: GrandAides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Dried Plum (Prune) Intake on the Incidence of Low Anterior Resection Syndrome in Patients With Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: OTHER: Prune (dried plum)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of HBV-002 West Nile Vaccine in Healthy Adults
Status: COMPLETED
Conditions: West Nile Virus Disease
Interventions: BIOLOGICAL: WN-80E|BIOLOGICAL: WN-80E|BIOLOGICAL: WN-80E|BIOLOGICAL: WN-80E
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy and Long-term Extension Treatment With Aticaprant
Status: RECRUITING
Conditions: Depressive Disorder, Major|Anhedonia
Interventions: DRUG: Aticaprant|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunomodulation Effect of Regional Citrate Anticoagulation in Acute Kidney Injury Requiring Continuous Renal Replacement Therapy
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: PROCEDURE: Continuous renal replacement therapy with regional citrate anticoagulation|PROCEDURE: Continuous renal replacement therapy with no anticoagulation or heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Luteal Phase-start Ovarian Stimulation With Corifollitropin Alfa
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Follicular phase corifollitropin alfa|DRUG: Luteal phase corifollitropin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation.
Status: COMPLETED
Conditions: Alzheimers Disease|Dementia|Alzheimers Disease, Familial
Interventions: DRUG: Gantenerumab|DRUG: Solanezumab|DRUG: Matching Placebo (Gantenerumab)|DRUG: Matching Placebo (Solanezumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Local Anesthetic Infiltration and Different Fascial Plane Blocks in Inguinal Hernia Repair
Status: RECRUITING
Conditions: Postoperative Pain|Inguinal Hernia|Local Infiltration|Quality of Recovery|Quadratus Lumborum Block|Transversus Abdominis Plane Block
Interventions: PROCEDURE: Anterior quadratus lumborum block|PROCEDURE: Transversus abdominis plane block|PROCEDURE: Local infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ability to Maintain Saturation Levels Without Oxygen Supplementation as a Extubation Criteria Without TOF Monitoring Equipment
Status: ENROLLING_BY_INVITATION
Conditions: Anesthesia Intubation Complication
Interventions: DEVICE: Train of four monitoring device intraoperative|DRUG: Neostigmine|PROCEDURE: Air chalenge prior to extubation|DEVICE: Train of Four monitoring device in recovery room
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ageing as a Mindset: A Counterclockwise Experiment to Rejuvenate Older Adults
Status: COMPLETED
Conditions: Aging
Interventions: BEHAVIORAL: Counterclockwise program|BEHAVIORAL: Active control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Delivering a Quitline Based Smoking Cessation Intervention in Cancer Patients
Status: COMPLETED
Conditions: Lung Cancer|Tobacco Use Disorder|Breast Cancer|Colorectal Cancer|Prostate Cancer
Interventions: DRUG: Nicotine Replacement Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effectiveness of Small Bowel Decompression Techniques in Patients With Small Bowel Obstruction
Status: RECRUITING
Conditions: Small Bowel Obstruction|Small Bowel Obstruction Adhesion|Small-Bowel Obstruction Due to Volvulus|Hernia Incarcerated
Interventions: DEVICE: Intraoperative intestinal decompression
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dasatinib In Combination With Trastuzumab And Paclitaxel In First Line Treatment Of Her2-Positive MBC Patients
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Dasatinib|DRUG: Trastuzumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of OTO-104 in Subjects With Unilateral Meniere's Disease
Status: TERMINATED
Conditions: Meniere's Disease
Interventions: DRUG: OTO-104|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NSS-2-BRIDGE Study for Total Knee and Hip Arthroplasties, Bariatric, and Kidney Transplant Surgeries
Status: COMPLETED
Conditions: Acute Pain|Arthropathy of Knee|Arthropathy of Hip|Pain, Postoperative|Kidney Transplant Donor|Bariatric Surgery Candidate
Interventions: DEVICE: NSS-2 Bridge
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sirolimus Versus Anti-Vascular Endothelial Growth Factor (antiVEGF) for Wet AMD
Status: COMPLETED
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: Sirolimus|DRUG: Standard of Care intravitreal injections of anti-VEGF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Stibium Metallicum Praeparatum 6x Versus Placebo in the Prevention of Paclitaxel-induced Peripheral Neurotoxicity
Status: NOT_YET_RECRUITING
Conditions: Chemotherapy Induced Peripheral Neuropathy (CIPN)
Interventions: DRUG: Stibium metallicum praeparatum 6x|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Study of Pyrotinib and Trastuzumab Plus Vinorelbine in Trastuzumab-refractory HER2-Positive Breast Cancer.
Status: UNKNOWN
Conditions: HER2 Positive Breast Cancer
Interventions: DRUG: Pyrotinib and Trastuzumab plus Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Concurrent Chemoradiotherapy Based of Cisplatin With or Without Sintilimab as First-line Therapy for Patients With Advanced Oral Cavity Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Oral Cavity Squamous Cell Carcinoma
Interventions: DRUG: Sintilimab|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cord Blood for Neonatal Hypoxic-ischemic Encephalopathy
Status: COMPLETED
Conditions: Neonatal Hypoxic Ischemic Encephalopathy
Interventions: BIOLOGICAL: infusion of autologous cord blood|OTHER: Neurodevelopmental outcomes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Effect of Stellate Ganglion Block on Gastroesophageal Reflux Disease
Status: WITHDRAWN
Conditions: Gastroesophageal Reflux Disease
Interventions: BEHAVIORAL: Rehabilitation therapy|PROCEDURE: Stellate ganglion block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Stem Cells for Cerebral Palsy Phase II
Status: UNKNOWN
Conditions: Cerebral Palsy
Interventions: BIOLOGICAL: Autologous Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vmax Detection of Acupuncture-doxofylline as a Whole Probe of CYP1A in Vivo
Status: UNKNOWN
Conditions: Acupuncture|Drug Interaction
Interventions: DEVICE: DOXO+electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rituximab Plus Sargramostim (GM-CSF) In Patients With Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: GM-CSF (Sargramostim)|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Phosphorus in Diet Induced Thermogenesis (DIT) of Both Lean and Obese Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Effect of phosphorus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Umbilical vs Paraumbilical Trocar Placement in Patients Undergoing Elective Laparoscopic Cholecystectomy
Status: UNKNOWN
Conditions: Incisional Hernia
Interventions: PROCEDURE: Umbilical port placement|PROCEDURE: Paraumbilical port placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Assess Absolute Bioavailability of TAK-935 (OV935) and to Characterize Mass Balance, Pharmacokinetics, Metabolism, and Excretion of [14C]TAK-935 (OV935) in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: TAK-935 Oral Tablet|DRUG: [14C]TAK-935 IV Infusion|DRUG: [14C]TAK-935 Oral Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Do Biomarkers Predict Response to a Pediatric Chronic Pain Symptom Management Program?
Status: RECRUITING
Conditions: Irritable Bowel Syndrome|Functional Abdominal Pain Syndrome|Functional Gastrointestinal Disorders|Functional Bowel Disorder|Functional Abdominal Pain|Functional Abdominal Pain Disorders
Interventions: OTHER: Cognitive Behavioral Therapy|OTHER: Low FODMAP Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tumor Control, Treatment Toxicity, Quality of Life and Bio-Imaging Repository Databank (TQ-BIRD) for Cancer Patients
Status: RECRUITING
Conditions: Cancer
Interventions: OTHER: No experimental interventions 1. Observation; 2. Anticancer treatments, including surgery, systemic therapy, radiotherapy, Chinese traditional medicine, or palliative/supportive care.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Bronchial Segmental Endotoxin Instillation in Humans
Status: SUSPENDED
Conditions: Acute Lung Inflammation
Interventions: OTHER: Saline|BIOLOGICAL: Endotoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Biomarkers in Parkinsonian Syndromes
Status: RECRUITING
Conditions: Parkinsonian Syndromes|Parkinson's Disease|Multiple System Atrophy|Progressive Supranuclear Palsy
Interventions: OTHER: CSF, blood and urine sampling|OTHER: clinical measures of disease severity and progression
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Colloids Versus Crystalloids for Fluid Resuscitation in Critically Ill Patients
Status: COMPLETED
Conditions: Critical Illness
Interventions: DRUG: Crystalloids|DRUG: Colloids|DRUG: Crystalloids|DRUG: Colloids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Soft Tissue Evaluation Around Implants Using Prf or a Palatal Pedicle
Status: UNKNOWN
Conditions: Soft Tissue Augmentation
Interventions: PROCEDURE: PRF|PROCEDURE: Palatal Pedicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Male and Female Participants (After Menopause) With Mild to Moderate High Blood Pressure to Learn How Safe the Study Treatment BAY3283142 is, How it Affects the Body and How it Moves Into, Through and Out of the Body After Taking Single and Multiple Doses
Status: COMPLETED
Conditions: Chronic Kidney Disease|Hypertension
Interventions: DRUG: BAY3283142|DRUG: Placebo to BAY3283142
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Dextrose Prolotherapy in Rotator Cuff Disease
Status: COMPLETED
Conditions: Rotator Cuff Disease
Interventions: OTHER: Dextrose Prolotherapy Injection|OTHER: Saline Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy for Insomnia in Type 2 Diabetes Mellitus
Status: RECRUITING
Conditions: Type 2 Diabetes|Insomnia
Interventions: BEHAVIORAL: cognitive behavioral therapy for insomnia|BEHAVIORAL: Health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Immunogenicity of AVT04 With Moderate-to-Severe Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Stelara|DRUG: AVT04
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Double-Flap Incision, Modified Periosteal Releasing Incision, and Coronally Advanced Lingual Flap to Periosteal Releasing Incision for Flap Advancement
Status: COMPLETED
Conditions: Flap Advancement
Interventions: PROCEDURE: Double Flap Incision|PROCEDURE: Modified Periosteal Releasing Incision|PROCEDURE: Coronally Advanced Lingual Flap|PROCEDURE: Periosteal releasing incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Myofascial Release and Electrical Stimulation in Chronic Pelvic Pain
Status: RECRUITING
Conditions: Chronic Pelvic Pain|Myofascial Trigger Point Pain
Interventions: DEVICE: TENS|OTHER: Myofascial trigger point release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Iron Sucrose in Children
Status: COMPLETED
Conditions: Anemia|Chronic Kidney Disease
Interventions: DRUG: Venofer (iron sucrose injection)|DRUG: Venofer (iron sucrose injection)|DRUG: Venofer (iron sucrose injection)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combining Anti-PD-L1 Immune Checkpoint Inhibitor Durvalumab With TLR-3 Agonist Rintatolimod in Patients With Metastatic Pancreatic Ductal Adenocarcinoma for Therapy Efficacy
Status: RECRUITING
Conditions: Metastatic Pancreatic Cancer
Interventions: BIOLOGICAL: Durvalumab|DRUG: Rintatolimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: PIPA: Combination of PI3 Kinase Inhibitors and PAlbociclib
Status: UNKNOWN
Conditions: Advanced Solid Tumours|Breast Cancer
Interventions: DRUG: Palbociclib + Taselisib / Pictilisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of EQU-001 for Uncontrolled Focal Onset Seizures
Status: TERMINATED
Conditions: Focal Onset Seizures
Interventions: DRUG: EQU-001|OTHER: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ertapenem Versus Meropenem/Imipenem for ESBL+ Gram-negative Infections
Status: UNKNOWN
Conditions: Drug Safety
Interventions: DRUG: Ertapenem|DRUG: Meropenem or Imipenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mesh Fixation in Lichtenstein Hernioplasty
Status: UNKNOWN
Conditions: Inguinal Hernia
Interventions: DEVICE: Histoacryl|DEVICE: Progrip|DEVICE: sutures (prolene 3-0)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Potassium Binders in the ER
Status: RECRUITING
Conditions: Acute Hyperkalemia|Oral Potassium Binders
Interventions: DRUG: Polyethylene Glycol 3350|DRUG: Sodium Polystyrene Sulfonate Oral Suspension [SPS]|DRUG: Patiromer|DRUG: Sodium zirconium cyclosilicate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Trial to Assess the Efficacy and Safety of Nafamostat Mesilate During Continuous Renal Replacement Therapy
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: DRUG: Nafamostat mesilate|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bladder and TranscUtaneous Tibial Nerve Stimulation for nEurogenic Lower Urinary Tract Dysfunction
Status: RECRUITING
Conditions: Neurogenic Bladder Dysfunction
Interventions: DEVICE: Experimental TTNS|DEVICE: Sham TTNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the Rivastigmine Transdermal Patch in Patients With Probable Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease|Dementia, Alzheimer Type
Interventions: DRUG: rivastigmine transdermal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Temozolomide and Interferon Alfa in Treating Patients With Stage III or Stage IV Melanoma
Status: COMPLETED
Conditions: Intraocular Melanoma|Melanoma (Skin)
Interventions: BIOLOGICAL: pegylated interferon alfa|DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Dehydroepiandrosterone (DHEA) and Letrozole in Treating Patients With Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: letrozole|DRUG: DHEA|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Coenzyme A Combined With Statin on Serum Lipids in Patients With Hyperlipidemia
Status: UNKNOWN
Conditions: Hyperlipoproteinemia
Interventions: DRUG: Coenzyme A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the ACAT Inhibitor CS-505 (Pactimibe) for Reducing the Progression of Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DRUG: Pactimibe, CS-505
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immune CHeckpoint Inhibitors Monitoring of Adverse Drug ReAction
Status: COMPLETED
Conditions: Arthritis|Cancer|Cardiac Disease|Endocrine System Diseases|Autoimmune Diseases|Ophthalmopathy|Myositis|Neuropathy
Interventions: DRUG: Immune checkpoint inhibitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Behavioural Economics-based Incentives in Adults With Type 2 Diabetes Pilot Study
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Financial and social incentives
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Examination of the Effects of Chromium Levels on Glucose Metabolism, Lipid Metabolism, Morbidity and Mortality Rates in Patients Followed in Intensive Care Unit
Status: RECRUITING
Conditions: Chromium Deficiency|Diabetes Mellitus|Hyperlipidemias|Hypercholesterolemia
Interventions: DIAGNOSTIC_TEST: Serum Chromium Level
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Translating Clinicians' Beliefs Into Implementation Interventions (TRACII)
Status: COMPLETED
Conditions: Upper Respiratory Tract Infection|URTI
Interventions: BEHAVIORAL: Psychological theory-based behaviour change interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Design & Evaluation of a Medication Therapy Management Program to Improve Patient Safety in Medicare Beneficiaries
Status: COMPLETED
Conditions: Chronic Illness|Adverse Effects|Medication Errors|Elderly Patients
Interventions: BEHAVIORAL: Basic medication therapy management|BEHAVIORAL: Enhanced medication therapy management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quality of Recovery After Dexamethasone, Ondansetron or Placebo Intrathecal Morphine Administration
Status: COMPLETED
Conditions: Fractures, Bone|Nausea and Vomiting, Postoperative|Pruritus|Morphine Adverse Reaction|Satisfaction, Personal
Interventions: DRUG: Dexamethasone|DRUG: Ondansetron|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: IV Iron Trial for Anemia Related to Uterine Bleeding in Female Patients Presenting to the Emergency Department
Status: RECRUITING
Conditions: Anemia, Iron Deficiency|Uterine Bleeding
Interventions: DRUG: Ferric Derisomaltose 1000 Mg in 10 mL INTRAVENOUS SOLUTION [Monoferric]|DRUG: Ferrous Sulfate 65 mg elemental iron (325 mg tablets)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ulcerative Colitis Relapse Prevention Trial, Hypnosis
Status: COMPLETED
Conditions: Ulcerative Colitis|Inflammatory Bowel Disease
Interventions: BEHAVIORAL: Hypnotherapy|BEHAVIORAL: Standard care|BEHAVIORAL: Mind Body Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Advanced NanoTherapies Dual-API DCB to Treat De-Novo Lesions in Patients With Symptomatic Coronary Artery Disease
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: SirPlux Duo™ Dual-API Coated PTCA Balloon Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of pCAR-19B in the Treatment of Adult CD19-positive Relapsed/Refractory B-ALL
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia, in Relapse|Refractory Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: pCAR-19B cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotics and Endotoxemia
Status: COMPLETED
Conditions: Metabolic Endotoxemia|Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Probiotic bacterium Bifidobacterium lactis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Intervention Targetting Obesity and Insulin Resistance in Chronic Hepatitis C
Status: COMPLETED
Conditions: Obesity|Insulin Resistance|Metabolic Syndrome|Hepatitis C
Interventions: OTHER: Lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy and the Nicotine Transdermal Patch for Cannabis Dependence and Nicotine Dependence
Status: COMPLETED
Conditions: Cannabis Dependence|Nicotine Dependence
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|DRUG: Nicotine Replacement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess AFM24 in Combination With Atezolizumab in Selected Advanced/Metastatic EGFR-expressing Cancers
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: AFM24|DRUG: Atezolizumab 840 MG in 14 ML Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CryoValve SG Pulmonary Human Heart Valve Post Clearance Study
Status: COMPLETED
Conditions: Pulmonary Valve Stenosis|Pulmonary Valve Insufficiency|Aortic Valve Stenosis|Aortic Valve Insufficiency
Interventions: PROCEDURE: Echocardiogram
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Uric Acid Study in Healthy Male Volunteers
Status: COMPLETED
Conditions: Gout|Coronary Artery Disease
Interventions: DRUG: AZD6140|DRUG: Placebo to match AZD6140
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Testosterone in Treating Postmenopausal Patients With Arthralgia Caused by Adjuvant Aromatase Inhibitor Treatment
Status: COMPLETED
Conditions: Arthralgia|Breast Cancer|Hot Flashes|Musculoskeletal Complications|Sexual Dysfunction
Interventions: DRUG: testosterone|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety Study of Low Dose Oral Contraceptive Pill to Treat Dysmenorrhea
Status: COMPLETED
Conditions: Dysmenorrhea
Interventions: DRUG: Norethisterone,Ethinylestradiol|DRUG: Sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sham Controlled Clinical Trial of Renal Denervation in Patients With Resistant Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DEVICE: Renal Denervation|OTHER: Sham control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasible Means to Address Moderately Malnourished Children Within BINP Communities
Status: COMPLETED
Conditions: Mild and Moderate Malnourished Children
Interventions: BEHAVIORAL: Prospective Longitudinal Interventional Stury
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Single Stage Root Coverage for Gingival Recession With or Without Free Gingival Graft
Status: COMPLETED
Conditions: Gingival Recession
Interventions: PROCEDURE: semilunar coronally positioned flap with free gingival graft|PROCEDURE: semilunar coronally positioned flap alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dietary Treatment of Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease|Inflammatory Bowel Disease
Interventions: DRUG: Active fructo-oligosaccharide|DRUG: Placebo fructo-oligosaccharide|DIETARY_SUPPLEMENT: Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT