pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Single Arm Phase 2 Study of Pemetrexed as 2nd-Line Treatment of Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small Cell Lung
Interventions: DRUG: pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Preventive Treatment (IPTc) and Home Based Management of Malaria (HMM)in The Gambia
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: SP plus amodiaquine|DRUG: SP placebo plus amodiaquine placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Adaption of the STAIR-NT Trauma Intervention for Polysubstance Populations
Status: NOT_YET_RECRUITING
Conditions: Polysubstance Abuse|Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Skills Training in Affective and Interpersonal Regulation with Narrative Therapy (STAIR-NT)|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Caffeine and Coffee on Resting Metabolic Rate, Comparing Normal Weight Men to Obese Men
Status: COMPLETED
Conditions: Asymptomatic Conditions
Interventions: DIETARY_SUPPLEMENT: Caffeine|DIETARY_SUPPLEMENT: Placebo|OTHER: Coffee|OTHER: Decaffeinated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Luteal vs Follicular Surgical Oophorectomy and Tamoxifen in Premenopausal Women With Metastatic Hormone Receptor Positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: oophorectomy|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Lebrikizumab in Patients Whose Asthma is Uncontrolled With Inhaled Corticosteroids and A Second Controller Medication (LUTE)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: lebrikizumab|DRUG: lebrikizumab|DRUG: lebrikizumab|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Integrated Computational modelIng of Right Heart Mechanics and Blood Flow Dynamics in Congenital Heart Disease
Status: UNKNOWN
Conditions: Congenital Heart Disease|Pulmonary Hypertension
Interventions: PROCEDURE: Cardiac Magnetic Resonance - MRI|OTHER: Cardiopulmonary Exercise Test|OTHER: Blood Sampling for all participants
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bafetinib in Treating Patients With Recurrent High-Grade Glioma or Brain Metastases
Status: COMPLETED
Conditions: Adult Anaplastic Astrocytoma|Adult Anaplastic Ependymoma|Adult Anaplastic Oligodendroglioma|Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Adult Mixed Glioma|Recurrent Adult Brain Tumor|Tumors Metastatic to Brain|Adult Anaplastic Oligoastrocytoma
Interventions: DRUG: bafetinib|PROCEDURE: microdialysis|OTHER: pharmacological study|OTHER: liquid chromatography|OTHER: mass spectrometry|OTHER: laboratory biomarker analysis|GENETIC: protein expression analysis|GENETIC: western blotting|OTHER: immunohistochemistry staining method|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carboplatin Plus Docetaxel (Taxotere) in Anaplastic Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Docetaxel|DRUG: Carboplatin|DRUG: Etoposide|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ocular Rigidity and Outflow Facility in Glaucomatous and Normal Eyes
Status: UNKNOWN
Conditions: Glaucoma
Interventions: PROCEDURE: Ocular rigidity, outflow facility and intraocular pressure measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy Study of Vaginal Mifepristone to Treat Uterine Fibroids
Status: COMPLETED
Conditions: Uterine Fibroid|Vaginal Bleeding.
Interventions: DRUG: mifepristone vaginal tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Recurrent Colon Cancer|Recurrent Rectal Cancer|Stage IV Colon Cancer|Stage IV Rectal Cancer
Interventions: DRUG: sorafenib tosylate|BIOLOGICAL: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label ProSpective MultiCENTer Study to Evaluate Safety and Tolerability of Dry Powder Inhaled Treprostinil in PH
Status: RECRUITING
Conditions: Pulmonary Hypertension|Interstitial Lung Disease
Interventions: COMBINATION_PRODUCT: LIQ861
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Role of Pulsed Dye Laser Therapy in the Management of Burn Scars
Status: RECRUITING
Conditions: Burn Scar
Interventions: PROCEDURE: pulsed dye laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Luspatercept (ACE-536) in Participants With Beta-thalassemia (A536-04/MK-6143-002)
Status: COMPLETED
Conditions: B-Thalassemia
Interventions: DRUG: luspatercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fludeoxyglucose (FDG) Positron Emission Tomography/Computed Tomography (PET/CT) Cervical Heterogenity Imaging Study
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Insulin Resistance Associated With Chronic Hepatitis C (CHC) and the Effect of Antiviral Therapy
Status: UNKNOWN
Conditions: Hepatitis C|Hepatitis B
Interventions: DRUG: Pegasys; Copegus.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ascending Dose Study to Investigate the Safety, Tolerability and Pharmacokinetics of BAY1128688 After Multiple Oral Administrations in Healthy Women
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: BAY1128688|DRUG: Placebo|DRUG: BAY1128688
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Metabolic Causes of Thrombosis in Type 2 Diabetes - Question 4
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: OTHER: Hyperinsulinemic Hypoglycemic Clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial of PSORI-CM01（YXBCM01） Granule to Treat Stable Plaque Psoriasis
Status: TERMINATED
Conditions: Plaque Psoriasis
Interventions: DRUG: PSORI-CM01（YXBCM01） granule|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Olfaction Essential Oils on the Consumption of Benzodiazepine Receptor Agonists & Z-Drugs (BZRAs) Prescribed as " if Needed " in Psychiatric Outpatients (HECBA-PSY).
Status: RECRUITING
Conditions: Psychiatric Disorder|Benzodiazepine Withdrawal
Interventions: DRUG: Essences and Essential Oils
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Technology to Scale-Up an Occupational Sun Protection Policy Program
Status: ACTIVE_NOT_RECRUITING
Conditions: Skin Cancer
Interventions: BEHAVIORAL: Sun Safe Workplaces - Technology|BEHAVIORAL: Sun Safe Workplaces -In Person
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Darunavir and Rilpivirine Interactions With Etonogestrel Contraceptive Implant
Status: UNKNOWN
Conditions: HIV|Contraception
Interventions: DRUG: Etonogestrel 68Mg Implant|DRUG: rilpivirine|DRUG: darunavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VEC-162 Study in Adult Patients With Primary Insomnia
Status: COMPLETED
Conditions: Primary Insomnia
Interventions: DRUG: VEC-162 20 mg|DRUG: Placebo|DRUG: VEC-162 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Belzutifan (PT2977, MK-6482) in Combination With Cabozantinib in Patients With Clear Cell Renal Cell Carcinoma (ccRCC) (MK-6482-003)
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma (RCC)|Clear Cell Renal Cell Carcinoma (ccRCC)|Kidney Cancer|Renal Cancer|Renal Cell Carcinoma|Renal Cell Cancer Metastatic|Renal Cell Carcinoma Recurrent|Renal Cell Cancer, Recurrent|Kidney
Interventions: DRUG: Belzutifan|DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breast Cancer Lung Late Effects
Status: COMPLETED
Conditions: Radiation Injury|Breast Cancer
Interventions: RADIATION: Proton beam radiation therapy.|RADIATION: X-ray based radiation therapy|PROCEDURE: Computed Tomography (CT) Scan|PROCEDURE: Pulmonary Function Test (PFT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study Testing a Web-Based Moral Elevation Intervention for Veterans With PTSD and Moral Injury
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder|Moral Injury
Interventions: BEHAVIORAL: Moral Elevation intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Study to Determine the Expression of the Furin Protein in Patients With SARS-CoV-2 and Vaccinated Against Coronavirus
Status: TERMINATED
Conditions: COVID-19|SARS-CoV-2|Furin|RGMc Processing|Paired Basic Amino Acid Cleaving Enzyme (PACE)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Study the Beneficial Effect of Mustard Oil and Salt Massaging With Oral Prophylaxis in Patients With Gum Diseases
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: PROCEDURE: SCALING AND ROOT PLANING (SRP)|PROCEDURE: MUSTARD OIL AND SALT MASSAGE WITH SRP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluciclovine (18F) PET/CT in biochemicAL reCurrence Of Prostate caNcer
Status: COMPLETED
Conditions: Cancer of the Prostate
Interventions: DRUG: 18F-Fluciclovine PET CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Nutrition Regimens in Treating Patients With Cancer of the Upper Aerodigestive Tract
Status: COMPLETED
Conditions: Head and Neck Cancer|Infection|Malnutrition
Interventions: DIETARY_SUPPLEMENT: therapeutic nutritional supplementation|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: INCHANGE - Nintedanib for Changes in Cough and Dyspnea in Patients Suffering From Chronic Fibrosing Interstitial Lung Disease With a Progressive Phenotype in Everyday Clinical Practice: a Real-world Evaluation
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Diseases, Interstitial
Interventions: DRUG: Nintedanib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Microbial Enzyme Impact on Postprandial Nutrient Levels and Gastrointestinal Symptoms in Healthy Adults
Status: COMPLETED
Conditions: Digestive Health|Gastrointestinal Health
Interventions: DIETARY_SUPPLEMENT: Placebo + Meal|DIETARY_SUPPLEMENT: BC-006 + Meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Antibacterial Prophylaxis vs no Prophylaxis for Hematological Malignancies Patients Before Allo-HSCT
Status: UNKNOWN
Conditions: Antibacterial Prophylaxis|Hematological Malignancies|Allogenetic Hematopoietic Stem Cell Transplantation|Imipenem
Interventions: DRUG: Imipenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Toripalimab or Toripalimab in Combination With Carboplatin and Nab-paclitaxel in Untreated HNSCC (HNSCC-002)
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Toripalimab, nab-paclitaxel, carboplatin|DRUG: Toripalimab|PROCEDURE: Surgical resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fall Detection and Prevention for Memory Care Through Real-time Artificial Intelligence Applied to Video
Status: UNKNOWN
Conditions: Alzheimer's Disease and Related Dementia|Fall Injury
Interventions: BEHAVIORAL: SafelyYou Fall Prevention System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Immunogenicity of Tetanus Vaccine, Adsorbed in 18~44 Years Old Population
Status: COMPLETED
Conditions: Tetanus
Interventions: BIOLOGICAL: Investigational tetanus vaccine, adsorbed|BIOLOGICAL: Control tetanus vaccine, adsorbed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: 64Cu-SAR-bisPSMA Positron Emission Tomography of Patients With Known or Suspected Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: 64Cu-SAR-bisPSMA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Eflornithine and/or Diclofenac in Treating Patients With Sun-Damaged Skin
Status: COMPLETED
Conditions: Other Benign Neoplasm of Skin, Unspecified
Interventions: DRUG: Diclofenac Na gel|DRUG: Eflornithine HCL ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Single Site Thoracic Surgery for Pediatric Pneumothorax
Status: COMPLETED
Conditions: Pediatric Disorder|Pneumothorax, Spontaneous|Thoracic Diseases|Thoracic Surgery
Interventions: PROCEDURE: Conventional multiport thoracoscopic surgery|PROCEDURE: Single port site thoracoscopic surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Depot Formulation of Sunitinib Malate (GB-102) in Subjects With Neovascular (Wet) Age-related Macular Degeneration
Status: COMPLETED
Conditions: Neovascular Age-Related Macular Degeneration
Interventions: DRUG: GB-102|DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Autologous Bone Marrow Derived Mesenchymal Stem Cells in Critical Limb Ischemia
Status: WITHDRAWN
Conditions: Critical Limb Ischemia
Interventions: DRUG: Cellgram-CLI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on Safety of tDCS One-shot in UCP
Status: COMPLETED
Conditions: Hemiplegic Cerebral Palsy
Interventions: DEVICE: real tDCS|DEVICE: sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Empathetic Communication Facilitation Program for Early Initiation of End-of-life Discussions
Status: RECRUITING
Conditions: End of Life Care|Advanced Cancer|Recurrent Cancer
Interventions: BEHAVIORAL: Mobile-based empathetic communication support program to promote ACP discussion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of CNTO 3157 in Healthy Normal and Asthmatic Participants Inoculated With Human Rhinovirus Type 16
Status: COMPLETED
Conditions: Healthy Volunteers and Asthma
Interventions: DRUG: CNTO 3157 (healthy participants)|DRUG: Placebo (healthy participants)|DRUG: CNTO 3157 (asthmatic patients)|DRUG: Placebo (asthmatic patients)|OTHER: HRV-16
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of a New Protease Inhibitor, BMS-232632, in Combination With Other Anti-HIV Drugs
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Atazanavir|DRUG: Nelfinavir mesylate|DRUG: Stavudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: This Study is to Assess the Efficacy and Safety of ZD6474 in Subjects With Non-small Cell Lung Cancer.
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer (NSCLC, Locally Advanced or Metastatic, Second-line
Interventions: DRUG: ZD6474|DRUG: Placebo|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Impact of a Pluridisciplinary Education Program on Venous Leg Ulcer Size Reduction
Status: COMPLETED
Conditions: Patient Empowerment|Venous Leg Ulcer|Interdisciplinary Communication
Interventions: OTHER: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Influence of Nutrition on Nasal and Bronchial Affliction in Patients With Allergy on Grass-Pollen
Status: COMPLETED
Conditions: Bronchial Hyperreactivity|Hypersensitivity|Allergy|Bronchial Asthma
Interventions: OTHER: inhalative specific bronchial provocation with grass-pollen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phenylbutyrate, Dexamethasone, and Sargramostim in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: sargramostim|DRUG: dexamethasone|DRUG: oral sodium phenylbutyrate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Bone-related and Soft-tissue-related Variables on the Marginal Bone Loss of Platform-matched and Platform Switched Dental Implants
Status: COMPLETED
Conditions: Dental Implant|Soft Tissue|Partial-edentulism|Bone Loss
Interventions: DEVICE: Switched Prosthetic Profile|DEVICE: Matched Prosthetic Profile
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Finding Treatments for Eating Disorders
Status: NOT_YET_RECRUITING
Conditions: Anorexia in Adolescence
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Auditory Stimulation of Slow Wave Sleep and Memory in Mild Cognitive Impairment and Older Adults
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: OTHER: Auditory stimulation during sleep|OTHER: Sham Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mometasone Furoate and Oxymetazoline in the Treatment of Adenoid Hypertrophy
Status: COMPLETED
Conditions: Adenoidal Hypertrophy
Interventions: DRUG: mometasone furoate|DRUG: Placebo|DRUG: Oxymetazoline + Placebo|DRUG: Placebo + placebo|DRUG: mometasone furoate + Placebo|DRUG: mometasone furoate + Oxymetazoline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerance of Abacavir/Lamivudine Treatment in Patients With Systemic Lupus Erythematosus
Status: NOT_YET_RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: Blood sample|DRUG: Treatment :Abacavir 600 mg/lamivudine 300 mg|OTHER: Lupus Impact Tracker questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of GW685698X In Patients With Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal
Interventions: DRUG: GW685698X Aqueous Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AssessinG Efficacy of Carboplatin and ATezOlizumab in Metastatic Lobular Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Carboplatin|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of BI 144807 Given Alone and in Combination With Ketoconazole in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ketoconazole|DRUG: BI 144807|DRUG: BI 144807
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Clinical and Cost-effectiveness of Different Mouthwashes on Controlling Halitosis Among a Group of Egyptian Children
Status: UNKNOWN
Conditions: Halitosis
Interventions: DRUG: Turmeric mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerance Evaluation of a Nighttime Moisturizing Balm on Babies and Adults With Eczema
Status: COMPLETED
Conditions: Atopic Dermatitis (AD)
Interventions: DRUG: Experimental Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II, Repeat Dose, Proof of Mechanism Study of Losmapimod to Reduce Proteinuria in Patients With Focal Segmental Glomerulosclerosis (FSGS)
Status: COMPLETED
Conditions: Glomerulosclerosis, Focal Segmental
Interventions: DRUG: Losmapimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of BIIB118 (PF-05251749)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIIB118|DRUG: BIIB118|DRUG: BIIB118
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intertrochanteric Femoral Fracture Fixation Trial
Status: UNKNOWN
Conditions: Intertrochanteric Fracture|Hip Fracture
Interventions: DEVICE: InterTan Intertrochanteric Nail|DEVICE: Gamma 3 Intertrochanteric Nail
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Skin Oxygenation Whilst Wearing Gradusox™ Compression Hosiery
Status: UNKNOWN
Conditions: Effect of Compression Hosiery on the Local Tissue Oxygenation and Compare This Effect Against That Achieved by Standard Compression Hosiery
Interventions: DEVICE: Graduated compression stockings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Web-based, Self-directed Intervention for Chronic Pelvic Pain
Status: RECRUITING
Conditions: Chronic Pelvic Pain|Endometriosis
Interventions: BEHAVIORAL: My Pelvic Plan Website|BEHAVIORAL: Control Group website
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Study of Cluster of Differentiation 38 (CD38) Monoclonal Antibody Combined Corticosteroid in Acquired Hemophilia A
Status: RECRUITING
Conditions: Acquired Hemophilia
Interventions: DRUG: Daratumumab and corticosteroid treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on Ventilator-associated Pneumonia as a Risk for Nosocomial Infection in Mechanically Ventilated Neonates In NICU of Assiut University Children Hospital (Nicu Eta)
Status: COMPLETED
Conditions: Neonatal SEPSIS|Nosocomially Acquired Neonatal Sepsis
Interventions: OTHER: others
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ketotifen as a Treatment for Vascular Leakage During Dengue Fever
Status: UNKNOWN
Conditions: Dengue Fever|Pleural Effusion
Interventions: DRUG: Ketotifen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Safety, Pharmacokinetics and the Effect of BIBR 1048 MS on Coagulation Parameters in Healthy Volunteer Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIBR 1048 MS - low dose|DRUG: BIBR 1048 MS - high dose|DRUG: BIBR 1048 MS + Pantoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Computer Controlled Local Anesthesia in Children
Status: COMPLETED
Conditions: Pain Perception of the New Device|The Pain Related Behavior|The Effectiveness of Anesthesia
Interventions: DEVICE: Computer controlled anesthesia|DEVICE: conventional anesthesia syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparing Fluoroscopy and Technological Methods for Guidance During Endovascular Procedures
Status: COMPLETED
Conditions: Aortic Aneurysm, Abdominal
Interventions: DEVICE: Technological Methods|DEVICE: Regular Fluoroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ScreenNC, a Study to Determine the Number of Asymptomatic Individuals Who Have Antibodies to the Virus That Causes COVID-19
Status: COMPLETED
Conditions: Asymptomatic Condition|Infection Viral|Coronavirus Infections|Severe Acute Respiratory Syndrome Coronavirus 2|Coronaviridae Infections|RNA Virus Infections|Virus Diseases|Communicable Disease
Interventions: DIAGNOSTIC_TEST: To assess for development of IgG antibodies against SARS-CoV2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lumbar School Training or Core Stabilization Exercises on Pain, Mobilization and Quality of Life Low Back Pain
Status: RECRUITING
Conditions: Low Back Pain|Core Stability|Core-based Exercise|Back School
Interventions: OTHER: Core stabilizasyon and lumbal back school
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clofarabine, Cytarabine, and Idarubicin in Treating Patients With Intermediate-Risk or High-Risk Acute Myeloid Leukemia or High-Risk Myelodysplasia
Status: UNKNOWN
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: clofarabine|DRUG: cytarabine|DRUG: idarubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strengthening Families and Reducing Risk Thru Developmental and Legal Collaboration
Status: COMPLETED
Conditions: Parenting|Child Rearing|Child Abuse|Child Neglect|Child Development
Interventions: BEHAVIORAL: Project dulce|BEHAVIORAL: Safety intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacogenetics of Remifentanil in Patients With Hypertension Undergoing Cesarean Delivery Under General Anesthesia
Status: COMPLETED
Conditions: Pregnancy|Cesarean Delivery|General Anesthesia
Interventions: DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Evaluate the Safety of Veliparib in Combination With Temozolomide in Subjects With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor Cancers
Interventions: DRUG: veliparib|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Molecular Profiling Study of Patients With EGFR Mutation-positive Locally Advanced or Metastatic NSCLC Treated With Osimertinib
Status: COMPLETED
Conditions: EGFR Mutation Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Interventions: DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deciphering Mechanisms Underlying Cancer Immunogenicity
Status: RECRUITING
Conditions: Head and Neck Cancer|Ovarian Cancer|Cervical Cancer|Cervical Intraepithelial Neoplasia 3|Glioblastoma Multiforme of Brain Stem|Non Small Cell Lung Cancer|Anal Cancer
Interventions: OTHER: Blood samples, tumor biopsy specimens and ascites samples will be collected.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Polyprenols (Ropren) in Acute Coronary Syndrome
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Ropren|OTHER: Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-assisted Thoracic Epidural Catheter Insertion
Status: COMPLETED
Conditions: Abdominal Neoplasm|Thoracic Neoplasm
Interventions: PROCEDURE: Ultrasound-guided TECI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Long Term Antibiotic Therapy on Exacerbation Rate in Stable COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Doxycycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b Study of TAK-700 in Postmenopausal Women With Hormone-receptor Positive Metastatic Breast Cancer
Status: COMPLETED
Conditions: Post Menopausal, Hormone Receptor Positive Breast Cancer
Interventions: DRUG: TAK700
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Recombinant Human Papillomavirus Vaccine(6,11,16,18,31,33,45,52,58 Type)(E.Coli)
Status: COMPLETED
Conditions: Condylomata Acuminata|Cervical Cancer
Interventions: BIOLOGICAL: HPV Vaccine,135μg/0.5ml|BIOLOGICAL: HPV Vaccine,270μg/1.0ml
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of SBRT Combined With Puterizumab in Intrapulmonary Metastasis From NSCLC
Status: NOT_YET_RECRUITING
Conditions: Non-Small-Cell Lung Cancer
Interventions: RADIATION: Stereotactic Body Radiation Therapy，SBRT|DRUG: Puterizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of AZD5305 When Given in Combination With New Hormonal Agents in Patients With Metastatic Prostate Cancer
Status: RECRUITING
Conditions: Metastatic Prostate Cancer
Interventions: DRUG: AZD5305|DRUG: Enzalutamide|DRUG: Abiraterone Acetate|DRUG: Darolutamide|DRUG: Apalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Pregnancy Outcomes in Good Prognosis Patients Between Fresh and 'Freeze-All' Single Blastocyst Transfers
Status: TERMINATED
Conditions: Infertility
Interventions: PROCEDURE: Freeze-All Protocol|PROCEDURE: Fresh Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Biopsy Development to Identify Patient's Glioma Grade at the CHU of Poitiers Using Magnetic Resonance Imaging
Status: RECRUITING
Conditions: Development of the Virtual Biopsy|Tumor Grade|Artificial Intelligence Algorithms|Clinical|Radiological
Interventions: DIAGNOSTIC_TEST: Diagnostic test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Dolutegravir (DTG) on PK of Cenicriviroc (CVC), and CVC on PK of DTG & on a Single Dose of Midazolam
Status: COMPLETED
Conditions: HIV-infection/AIDS
Interventions: DRUG: Cenicriviroc|DRUG: Dolutegravir|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Long-Term Safety Trial of LUM-201 in Children With Idiopathic Growth Hormone Deficiency Who Have Previously Completed a LUM-201 Clinical Trial (OraGrowtH211)
Status: ENROLLING_BY_INVITATION
Conditions: Growth Hormone Deficiency
Interventions: DRUG: LUM-201
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Circadian Ocular Perfusion Pressure and Ocular Blood Flow
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: Brinzolamide 10 mg/ml/Timolol 5 mg/ml eye drops suspension|DRUG: Brimonidine 20 mg/ml/Timolol 5 mg/ml eye drops solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BTT-1023 in Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: BTT-1023|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: THEMBA II T-Cell Vaccine: Vaccination With saRNA COVID-19 Vaccines
Status: TERMINATED
Conditions: COVID-19
Interventions: BIOLOGICAL: AAHI-SC2 Vaccine|BIOLOGICAL: AAHI-SC3 Vaccine|BIOLOGICAL: EUA or approved vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prostate Specific Antigen (PSA) and Acute Failure Modes Study of the PATH Woman's Condom and FC2 Female Condom
Status: COMPLETED
Conditions: Birth Control
Interventions: DEVICE: WC then FC2|DEVICE: FC2 then WC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Pharmacokinetic Study of a Recombinant Coagulation Factor IX Albumin Fusion Protein in Subjects With Hemophilia B
Status: COMPLETED
Conditions: Hemophilia B
Interventions: BIOLOGICAL: Recombinant Coagulation Factor IX Albumin Fusion Protein|BIOLOGICAL: Plasma derived FIX [pdFIX]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM
Status: RECRUITING
Conditions: Glioblastoma|Glioblastoma Multiforme|Glioma, Malignant|GBM|Brain Cancer|Glioblastoma, IDH-wildtype|Glioblastoma Multiforme, Adult
Interventions: DRUG: Repeated Superselective Intraarterial Cerebral infusion (SIACI) of Bevacizumab (Avastin) with Temozolomide and Radiation|DRUG: Temozolomide and Radiation Alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Telitacicept in the Treatment of Systemic Sclerosis
Status: RECRUITING
Conditions: Systemic Sclerosis
Interventions: DRUG: Telitacicept
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intra-articular NSAID Versus Corticosteroid in the Treatment of Shoulder and Knee Conditions: A Randomized, Double-Blind, Prospective Study
Status: UNKNOWN
Conditions: Knee Arthritis|Shoulder Arthritis|Shoulder Impingement|Meniscus Lesion|Rotator Cuff Tear|Rotator Cuff Tear Arthropathy
Interventions: DRUG: Shoulder injection|DRUG: knee injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effects of BMS-986371 on the Drug Levels of Methotrexate in the Presence and Absence of Sulfasalazine
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Methotrexate|DRUG: Leucovorin|DRUG: BMS-986371|DRUG: Sulfasalazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Stability, Efficacy and Safety of the Silent™ Hip Prosthesis in Primary Total Hip Replacement
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: DePuy Silent™ Hip femoral prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Clinically Application of Magnetic Resonance Fingerprinting
Status: TERMINATED
Conditions: Neurofibromatosis Type 1|Brain Tumor|Glioma
Interventions: DEVICE: Magnetic Resonance Imaging|DEVICE: Magnetic Resonance Fingerprinting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prevention of Contrast Nephropathy by Sodium Bicarbonate Versus Sodium Chloride and N-acetylcysteine
Status: COMPLETED
Conditions: Acute Renal Failure Contrast Nephropathy
Interventions: DRUG: n acetylcysteine|DRUG: sodium bicarbonate|DRUG: sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Implant for Walking After Stroke
Status: RECRUITING
Conditions: Stroke|Hemiplegia|Gait, Hemiplegic
Interventions: DEVICE: IRS-8|DEVICE: IST 12 & IST 16
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine or Chloroquine/Azithromycin Prophylaxis
Status: WITHDRAWN
Conditions: Malaria, Falciparum
Interventions: DRUG: Azithromycin capsules|DRUG: Placebo|BIOLOGICAL: Immunization with falciparum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Orthostatic Intolerance After Bariatric Surgery
Status: COMPLETED
Conditions: Orthostatic Intolerance
Interventions: DRUG: Atomoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bone Mineral Density Status in Pediatric and Adolescent Survivors of Childhood Cancer With History of Bone Fracture
Status: COMPLETED
Conditions: Bone Mineral Density|Childhood Cancer Survivors
Interventions: OTHER: Dual energy x-ray absorptiometry (DXA)|OTHER: Peripheral quantitative computed tomography (pQCT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treprostinil Iontophoresis : a Pharmacodynamic and Pharmacokinetic Study
Status: UNKNOWN
Conditions: Scleroderma, Systemic
Interventions: DRUG: Cutaneous iontophoresis of treprostinil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rosiglitazone (Extended Release Tablets) As Adjunctive Therapy In Subjects With Mild To Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Rosiglitazone Extended Release 2mg|DRUG: Rosiglitazone Extended Release 8mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2a Evaluation of Safety, Tolerability, and Pharmacokinetics of PLN-74809 in Patients With Primary Sclerosing Cholangitis (PSC)
Status: COMPLETED
Conditions: Primary Sclerosing Cholangitis
Interventions: DRUG: PLN-74809|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enamel Abrasion and Stain Removal Efficacy of Two Whitening Toothpastes: An In-vitro and In-vivo Trial
Status: NOT_YET_RECRUITING
Conditions: Tooth Abrasion
Interventions: PROCEDURE: Charcoal based whitening toothpaste (signal charcoal white& Detox toothpaste Unilever Mashreq - Egypt|PROCEDURE: Calcium carbonate /perlite containing whitening toothpaste (signal whitening moonlight toothpaste Unilever Mashreq - Egypt).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial of Udenafil Therapy in Patients With Mild Pulmonary Hypertension [ULTIMATE-Mild PHT]
Status: UNKNOWN
Conditions: Mild Pulmonary Hypertension
Interventions: DRUG: Placebo|DRUG: Udenafil (Zydena)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study on Oncolytic Virus Injection (R130 OV) for the Treatment of Relapsed/Refractory Head and Neck Cancer
Status: RECRUITING
Conditions: Head and Neck Cancer|Esophageal Cancer|Otorhinolaryngologic Neoplasms|Ear Cancer|Nose Cancer|Laryngeal Cancer|Pharyngeal Cancer
Interventions: DRUG: Recombinant oncolytic herpes simplex virus type 1 (R130)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ganciclovir Plus Arginine Butyrate in Treating Patients With Cancer or Lymphoproliferative Disorders Associated With the Epstein Barr Virus
Status: COMPLETED
Conditions: Leukemia|Lymphoma|Precancerous Condition|Small Intestine Cancer
Interventions: DRUG: arginine butyrate|DRUG: ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The ESTxENDS Trial- Substudy on the Effects of Using Electronic Nicotine Delivery Systems (ENDS) on Depression
Status: COMPLETED
Conditions: Smoking Cessation|Depression
Interventions: OTHER: ENDS (vaporizer/e-cig) and smoking cessation counseling|OTHER: Smoking cessation counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Cocoa on Ambulatory Blood Pressure and Vascular Function in Patients With Stage I Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: 5g Cocoa Consumption|DIETARY_SUPPLEMENT: 10g Cocoa Consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Immunochemotherapy in Patients With T-Prolymphocytic Leukemia (T-PLL)
Status: COMPLETED
Conditions: T-cell-prolymphocytic Leukemia
Interventions: DRUG: Fludarabine, Mitoxantrone, Cyclophosphamide and Alemtuzumab|DRUG: Alemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Buprenorphine/Naloxone in the Treatment of Heroin Dependence - 14
Status: COMPLETED
Conditions: Opioid Dependence|Substance-Related Disorders
Interventions: DRUG: Buprenorphine/naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicohort Trial of Different Schemes of PM14 in Monotherapy and in Combination With Radiotherapy in Soft Tissue Sarcomas and Other Solid Tumor
Status: RECRUITING
Conditions: Advanced Soft-tissue Sarcoma|Advanced L-sarcomas|Other Advanced Sarcomas|Advanced Solid Tumor|Localized Soft-tissue Sarcoma
Interventions: DRUG: PM14
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Imaging of the Eustachian Tube; Patient Study
Status: COMPLETED
Conditions: Otitis Media With Effusion|Eustachian Tube Disorder
Interventions: PROCEDURE: Iodixanol to the Eustachian tube
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC