pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Feasibility and Smokers' Reactions to DNA Feedback
Status: COMPLETED
Conditions: Smoking
Interventions: BEHAVIORAL: standard health information|BEHAVIORAL: standard health information plus info. on DNA damage|BEHAVIORAL: Subjects will review standard health information and information on DNA damage, plus pictures of their DNA damage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of a Multimedia Symptom Management Program on Quality of Life in Patients With Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: The Multimedia Symptom Management Program Intervention|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess Safety, Tolerability and Efficacy of SC Administered MBL949 in Obese Participants With or Without T2DM
Status: TERMINATED
Conditions: Obesity
Interventions: DRUG: MBL949|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: eTest: Real-time, Remote Monitoring System for Home-based HIV Testing Among High-risk Men Who Have Sex With Men
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections
Interventions: DIAGNOSTIC_TEST: HIV self-test|BEHAVIORAL: Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Tailored Screening and Smoking Cessation Program for the LGBTQ Community of Seattle
Status: RECRUITING
Conditions: Lung Carcinoma
Interventions: BEHAVIORAL: Patient Navigation|OTHER: Questionnaire Administration|BEHAVIORAL: Smoking Cessation Intervention|PROCEDURE: Carbon Monoxide Measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of NT-proBNP in Chronic Inflammatory Bowel Disease
Status: TERMINATED
Conditions: Inflammatory Bowel Diseases|NT-pro-BNP
Interventions: OTHER: Evaluate the blood level of NTproBNP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Management of Metastatic Neck Nodes in N2/3 Hypopharyngeal Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Hypopharyngeal Carcinoma
Interventions: DRUG: Docetaxel|DRUG: Cisplatin|DRUG: Capecitabine|RADIATION: Concomitant chemoradiotherapy|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Cognitive Function in Older Adults Undergoing Stem Cell Transplant
Status: RECRUITING
Conditions: Leukemia|Lymphoma|Multiple Myeloma|MDS|Myeloproliferative Neoplasm
Interventions: BEHAVIORAL: CHAMPS-II adapted to adults 60+ years in HCT setting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stroke Wearable Operative Rehabilitation Device Impact Trial
Status: COMPLETED
Conditions: Ischemic Stroke|Upper Extremity Hemiparesis
Interventions: DEVICE: Vibratory feedback and 3D movement analysis|DEVICE: Only 3D movement analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate Clinical Outcomes of LuxSmart IOL as Compared With LuxGood IOL
Status: RECRUITING
Conditions: Cataract|Lens Opacities
Interventions: DEVICE: Implantation of premium monofocal IOL, LuxSmart (device under investigation)|DEVICE: Implantation of monofocal IOL, LuxGood (control device)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2a Study of Weekly Doses of GCS-100 in Patients With Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: GCS-100|DRUG: Placebo, Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Clinical Trial to Evaluate the Safety and Pharmacokinetic Characteristics of DW1809-T2
Status: COMPLETED
Conditions: Osteoarthritis|Rheumatoid Arthritis|Back Pain|Acute Upper Respiratory Tract Infection
Interventions: DRUG: DW1809-T2|DRUG: DW1809-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Problem Solving Treatment for Diabetes in Individuals With Poor Diabetes Control
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Problem Solving Treatment for Diabetes|BEHAVIORAL: Attention Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autofluorescence for the Screening of Precancerous and Malignant Lesions
Status: COMPLETED
Conditions: Precancerous Lesions of the Oral Mucosa
Interventions: PROCEDURE: buccal cavity examination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Tolerability of RAG-17 in the Treatment of Amyotrophic Lateral Sclerosis Patients With SOD1 Gene Mutation
Status: ENROLLING_BY_INVITATION
Conditions: Gene Mutation
Interventions: DRUG: RAG-17
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temporomandibular Disorder in Use of Levonorgestrel Intrauterine System
Status: RECRUITING
Conditions: Levonorgestrel Adverse Reaction|Temporomandibular Joint Disorders|Temporomandibular Disorder
Interventions: DIAGNOSTIC_TEST: Examination of temporomandibular joint and masticator muscles
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Relacorilant in Patients With Cortisol-Secreting Adrenal Adenomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypercortisolism
Interventions: DRUG: relacorilant|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 2019-06 TRISCEND Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Tricuspid Valve Regurgitation|Heart Valve Diseases|Cardiovascular Diseases
Interventions: DEVICE: Transcatheter Tricuspid Valve Replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protocol Based-furosemide Stress Test Versus Standard Care to Evaluate Renal Recovery During Continuous Renal Replacement Therapy
Status: RECRUITING
Conditions: Acute Kidney Injury
Interventions: DRUG: Furosemide Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cyclopol on Electrophysiological Monitoring During Spine Surgery: a Randomized Controlled, Noninferiority Study
Status: RECRUITING
Conditions: Visual Evoked Potentials
Interventions: DRUG: Cyclopol|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Communication Training in Promoting Employment Retention Among Cancer Patients
Status: TERMINATED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: OTHER: educational intervention|OTHER: communication skills training|OTHER: educational intervention|OTHER: questionnaire administration|OTHER: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Resveratrol, Cardiovascular Risk Markers And Cognitive Performance In Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: resveratrol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Contralateral Dispensing Clinical Trial of Study Test Sapphire Lens Against Enfilcon A Silicone Hydrogel Lens
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Sapphire Lens|DEVICE: enfilcon A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Uninterrupted Infant Respiratory Support Treatment
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Newborn|Infant, Newborn|Respiratory Insufficiency Syndrome of Newborn
Interventions: DEVICE: Uninterrupted CPAP for the first hours of life
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Practice Facilitation as a Strategy to Improve Alcohol Treatment Adoption and Implementation in HIV Care
Status: RECRUITING
Conditions: Hiv|Alcohol Use, Unspecified
Interventions: BEHAVIORAL: Practice Facilitation|BEHAVIORAL: Alcohol Stepped Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Peginterferon Alpha 2a Therapy in Chronic Hepatitis B Patients Being Treated With Nucleoside(Acid) Analogues
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: peginterferon alpha 2a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2a To Evaluate PL-8177 in Subjects With Active Ulcerative Colitis (UC)
Status: RECRUITING
Conditions: Ulcerative Colitis|Ulcerative Colitis Acute|Ulcerative|Ulcerative Colitis Flare
Interventions: DRUG: PL8177 Placebo|DRUG: PL8177
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Angiotensin-Neprilysin Inhibition in Diastolic Dysfunction After AMI
Status: UNKNOWN
Conditions: Myocardial Infarction|Diastolic Dysfunction
Interventions: DRUG: Valsartan+ sacubitril|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Implant Positioning With Robotic Aided Surgery and Traditional Jig Positioning in Total Knee Arthroplasty
Status: WITHDRAWN
Conditions: Knee Arthritis
Interventions: PROCEDURE: manually instrumented total knee arthroplasty|DEVICE: robotic assisted total knee arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine and Cisplatin in Treating Patients With Metastatic or Recurrent Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: cisplatin|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Immunosuppression After Repeat Keratoplasty
Status: UNKNOWN
Conditions: Keratopathy
Interventions: DRUG: prescribe topical 0.03 % tacrolimus|DRUG: prescribe mycophenolate mofetil(MMF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Intrapleural Bevacizumab and Cisplatin Therapy for Malignant Pleural Effusion Caused by Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Malignant Pleural Effusion
Interventions: DRUG: Bevacizumab|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-Dose Study of the Safety, Tolerability, and Pharmacokinetics of Odanacatib (MK0822) in Healthy Volunteers
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: odanacatib|DRUG: Comparator: odanacatib (Panel B)|DRUG: Comparator: odanacatib (Panel C)|DRUG: Comparator: odanacatib (Panel D)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-blind, Phase 3 Efficacy Trial of PROSTVAC-V/F +/- GM-CSF in Men With Asymptomatic or Minimally Symptomatic Metastatic Castrate-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer Metastatic
Interventions: BIOLOGICAL: PROSTVAC-V|BIOLOGICAL: PROSTVAC-F|DRUG: GM-CSF|OTHER: GM-CSF Placebo|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Primary Care Internet-Based Depression Prevention for Adolescents (CATCH-IT)
Status: WITHDRAWN
Conditions: Depression|Anxiety|Externalizing Symptoms|Substance Abuse
Interventions: BEHAVIORAL: CATCH-IT|BEHAVIORAL: AMPE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Promoting Smoking Cessation in the Community Via "Quit to Win" Contest 2017
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Instant Messaging IM|BEHAVIORAL: Regular messages|BEHAVIORAL: AWARD advice|BEHAVIORAL: Referral card|BEHAVIORAL: Brief advice|BEHAVIORAL: COSH booklet|BEHAVIORAL: Placebo Messages|BEHAVIORAL: Warning Leaflet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of the Safety and Efficacy of MK-3577 in Participants With Type 2 Diabetes Mellitus (MK-3577-009)
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: MK-3577|DRUG: Placebo to MK-3577|DRUG: Metformin|DRUG: Placebo to Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The RESTORE Study, A Randomized, Controlled, Masked (Reading Center) Prospective Study
Status: COMPLETED
Conditions: Refractive Surgery
Interventions: DRUG: Dextenza 0.4Mg Ophthalmic Insert|DRUG: Topical Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Azilsartan in Chinese Patients With Mild and Moderate Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Azilsartan tablets|DRUG: Azilsartan placebo tablets|DRUG: Olmesartan medoxomil tablets|DRUG: olmesartan medoxomil placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Migraine and CVD Risk in Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Migraine
Interventions: OTHER: Mixed meal tolerance testing|OTHER: Skin conductance & cold pressor test|OTHER: Flow-mediated dilation testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Respiratory Muscle Training for Patients With COPD and Mild Cognitive Impairment
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Mild Cognitive Impairment
Interventions: BEHAVIORAL: Respiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deep Repetitive Transcranial Magnetic Stimulation for Alcohol Use Disorder
Status: COMPLETED
Conditions: Alcohol Abuse
Interventions: DEVICE: Active dTMS|DEVICE: Sham dTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Effect of the Proton Pump Inhibitor Esomeprazole on the Single-dose Pharmacokinetics (PK) of Oral TAK-906 in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: TAK-906|DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: the Effect of Oral Vasopressors for Liberation From IV Vasopressors in Spinal Shock
Status: UNKNOWN
Conditions: Spinal Shock
Interventions: DRUG: Midodrine Oral Tablet|DRUG: Minirin oral tablet|DRUG: Nor-Adrenaline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Exercise Training on Obstructive Sleep Apnea Syndrome Severity
Status: COMPLETED
Conditions: Sleep Apnea Syndromes|Sleep Apnea, Obstructives
Interventions: OTHER: Training|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Multi-lead ECG to Effectively Optimize Resynchronization Devices: New CRT Recipients
Status: RECRUITING
Conditions: Heart Failure, Systolic
Interventions: DEVICE: Reprogramming of CRT Device Settings to Optimal Electrical Synchrony
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Pharmacokinetics of Mycophenolate Mofetil Metabolites From Four Tablet Formulations in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Renodapt|DRUG: Mycept|DRUG: Cellmune|DRUG: CellCept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK, PD, Safety and Immunogenicity of Spectrila in Adults With Acute B-cell Lymphoblastic Leukaemia
Status: RECRUITING
Conditions: Acute B-Cell Lymphoblastic Leukaemia
Interventions: DRUG: Spectrila®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Temozolomide and O6-Benzylguanine (O6-BG) in Patients With Temozolomide-Resistant Anaplastic Glioma
Status: TERMINATED
Conditions: Glioma|Astrocytoma|Oligodendroglioma|Oligoastrocytoma
Interventions: DRUG: Temozolomide and O6-Benzylguanine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Affect-based, Self-selected, and Traditional Exercise Prescriptions
Status: COMPLETED
Conditions: Physical Activity
Interventions: BEHAVIORAL: Choice-based Exercise Intensity|BEHAVIORAL: Positive Affect Focus|BEHAVIORAL: Heart rate-based Exercise Intensity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Internal Limiting Membrane Peeling for Large Macular Holes
Status: COMPLETED
Conditions: Macular Hole
Interventions: PROCEDURE: With Peeling of Limiting the Intern of the Retina|PROCEDURE: Internal limiting membrane peeling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Calcium and Phytate on Zinc Absorption
Status: COMPLETED
Conditions: Dietary Zinc Absorption
Interventions: DIETARY_SUPPLEMENT: Moderate Calcium, Low phytate Diet|DIETARY_SUPPLEMENT: Moderate Calcium, High Phytate Diet|DIETARY_SUPPLEMENT: High Calcium, Low Phytate Diet|DIETARY_SUPPLEMENT: High Calcium, High Phytate Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Local Steroid Injection vs Placebo in Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: DRUG: Methylprednisolone 80 mg|DRUG: Methylprednisolone 40 mg|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Besivance™ (Besifloxacin Ophthalmic Suspension) 0.6% Compared to Vehicle
Status: COMPLETED
Conditions: Bacterial Conjunctivitis
Interventions: DRUG: Besivance|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: COLOSPOT Study : Assessment by EPISPOT of Circulating Tumor Cells in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: OTHER: Blood analysis by EPISPOT and Cellsearch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Mycophenolate in Limited Cutaneous Systemic Sclerosis (MINIMISE-Pilot)
Status: ACTIVE_NOT_RECRUITING
Conditions: Systemic Sclerosis|Limited Cutaneous Systemic Sclerosis
Interventions: DRUG: Mycophenolate Mofetil 500mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Knowledge Mobilization Activities to Support Decision-Making by Youth, Parents and Adults: Study Protocol
Status: COMPLETED
Conditions: COVID-19
Interventions: OTHER: Plain Language Recommendation (PLR)|OTHER: Standard Language Version (SLV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Amiodarone + Propranolol|DRUG: Amiodarone|DRUG: Propranolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Trial of Increased Dose Intensity Modulated Proton Therapy (IMPT) for High-Grade Meningiomas
Status: RECRUITING
Conditions: Meningioma|Brain Tumor
Interventions: RADIATION: Intensity Modulated Proton Therapy (IMPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase IIa Clinical Trial on TSG-01 in the Treatment of Chronic Heart Failure in Patients With Coronary Heart Disease.
Status: COMPLETED
Conditions: Chronic Heart Failure
Interventions: DRUG: TSG-01|DRUG: TSG-01 and Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Mitomycin and Lobaplatin in Advanced Colorectal Cancer Patients With Radical Surgery Combined With Hyperthermic Intraperitoneal Chemotherapy
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer|Chemotherapy Effect|Surgery|Metastasis|Survival
Interventions: DRUG: Mitomycin|DRUG: Lobaplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Compare Ceftazidime-Avibactam + Metronidazole Versus Meropenem for Hospitalized Adults With Complicated Intra-Abdominal Infections
Status: COMPLETED
Conditions: Complicated Intra-Abdominal Infection
Interventions: DRUG: CAZ-AVI|DRUG: Metronidazole|DRUG: Meropenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Articaine Lozenge to Enhance the Procedural Compliance of the Adults Undergoing Gastroduodenoscopy
Status: UNKNOWN
Conditions: Dyspepsia|Hematemesis|Abdominal Pain|Heartburn
Interventions: DRUG: Anesthetics, Local|DRUG: Sodium Chloride 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Value of Adductor Canal vs Femoral Block After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteo Arthritis Knee
Interventions: PROCEDURE: Active comparator: chloroprocaine|PROCEDURE: Sham comparator: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Doxorubicin Hydrochloride Liposome and Rituximab With Combination Chemotherapy in Treating Patients With Newly Diagnosed Burkitt's Lymphoma or Burkitt-Like Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Regimen A|DRUG: Regimen B
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PTSD After ICU Survival - Caring for Patients With Traumatic Stress Sequelae Following Intensive Medical Care
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic
Interventions: OTHER: "Narrative Exposure Therapy"-oriented intervention|OTHER: improved treatment as usual (iTAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ENHANCE-EvideNce Led Co-created HeAlth Systems interventioNs for MLTCs CarE
Status: RECRUITING
Conditions: HIV Infections|Hypertension|Diabetes Mellitus|Asthma|Depression|Myocardial Infarction|Stroke
Interventions: OTHER: ENHANCE intervention (health systems)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Testing the Efficacy in Adults With Cold of HEalsea Rescue*
Status: COMPLETED
Conditions: Common Cold
Interventions: DEVICE: Healsea Rescue*|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Versus Magnesium Sulfate Infusion During Spinal Anesthesia
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Dexmedetomidine|DRUG: Magnesium Sulphate|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Antimicrobial Prophylaxis for Shock Wave Lithotripsy (SWL) on Reducing Urinary Tract Infection (UTI)
Status: TERMINATED
Conditions: Urolithiasis
Interventions: DRUG: Ciprofloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Single Anastomosis Versus Standard Duodenal Switch
Status: RECRUITING
Conditions: Obesity|Morbid Obesity
Interventions: PROCEDURE: Standard Duodenal Switch|PROCEDURE: Single Anastomosis Duodenal Switch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Wide-Field and High Resolution In Vivo Imaging in Visualizing Lesions in Patients With Oral Neoplasia Undergoing Surgery
Status: RECRUITING
Conditions: Oral Cavity Neoplasm
Interventions: PROCEDURE: High-Resolution Microendoscopy|PROCEDURE: Multispectral Imaging|DRUG: Proflavine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Novel Collagen Scaffold vs Conventional Scaffold in Regeneration of Human Dental Pulp Tissue
Status: WITHDRAWN
Conditions: Root Canal Therapy
Interventions: DRUG: Collagen-hydroxyapatite scaffold (Syn-Oss)|DRUG: Collagen Scaffold (Colla-Plug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Clenbuterol in Individuals With Late-onset Pompe Disease and Receiving Enzyme Replacement Therapy
Status: COMPLETED
Conditions: Pompe Disease
Interventions: DRUG: Clenbuterol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Oral Diltiazem on the Intraoperative Bleeding in Functional Endoscopic Sinus Surgery
Status: UNKNOWN
Conditions: Hypotension on Induction
Interventions: DRUG: oral Diltiazem|DRUG: IV Tranexamic Acid|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Using Telemedicine to Improve Spasticity Diagnosis Rates
Status: COMPLETED
Conditions: Spasticity, Muscle|Muscular Diseases|Musculoskeletal Disease|Muscle Hypertonia|Muscle Spasticity|Neuromuscular Manifestations|Signs and Symptoms|Nervous System Diseases|Neurologic Manifestations
Interventions: DIAGNOSTIC_TEST: Neurological Examination|DIAGNOSTIC_TEST: Teleneurological Examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Optimizing Communication During Ventilation
Status: COMPLETED
Conditions: Neuromuscular Disorder|Respiratory Failure
Interventions: DEVICE: Elysee 150 ventilator|DEVICE: Elysee 150 ventilator with a ventilation switch control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Breast Cancer|Extragonadal Germ Cell Tumor|Infection|Lung Cancer|Lymphoma|Ovarian Cancer|Small Intestine Cancer|Testicular Germ Cell Tumor|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Analysis of Fatigue on Tyrosine Kinase Inhibitor Therapy in Chronic Myeloid Leukaemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Myeloid Leukemia|Chronic Myeloid Leukemia, Chronic Phase|Fatigue|Sleep Disturbance
Interventions: DEVICE: Motion watch
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Quality of Life of Patients Who Have Rocket Indwelling Pleural Catheter Drainage or Repeated Large Volume Paracentesis
Status: UNKNOWN
Conditions: Ascites, Malignant
Interventions: DEVICE: Large Volume Paracentesis|DEVICE: Rocket Indwelling Pleural Catheter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Pain Catastrophizing-2 (SPAC-2)
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: BEHAVIORAL: Cognitive-Behavioral Intervention|BEHAVIORAL: Pain Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dose Sparing Intradermal S-OIV H1N1 Influenza Vaccination Device
Status: COMPLETED
Conditions: Influenza Infection
Interventions: BIOLOGICAL: S-OIV H1N1 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Metformin Continuation Versus Interruption Following Coronary Angiography: a Pilot Randomized Controlled Trial
Status: UNKNOWN
Conditions: Acute Coronary Syndrome|Unstable Angina|Diabetes Mellitus|Metformin Adverse Reaction
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability and Pharmacokinetics of a New Formulation of Oritavancin in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oritavancin|DRUG: Dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Investigate the Effect of PBF-680 on Forced Expiratory Volume in 1 Second (FEV1) in Asthmatic Patients
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: PBF-680|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase Ⅰ Study to Compare the Safety, Pharmacokinetic Profiles of CJ Amlodipine/Valsartan 10/160mg Tablet and Novartis Exforge 10/160mg Tablet
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CJ Amlodipine/Valsartan 10/160mg Novartis Exforge 10/160mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Co-administration of an NSAID With a Dopamine Agonist In Healthy Subjects
Status: WITHDRAWN
Conditions: Acute Pain
Interventions: DRUG: Naproxen|DRUG: Sinemet|DRUG: Sinemet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ibrutinib in Combination With Bendamustine and Rituximab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Ibrutinib|DRUG: Bendamustine hydrochloride|DRUG: Rituximab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Muscle Weakness Improvement With Lorcaserin in ICU
Status: TERMINATED
Conditions: Muscle Weakness|Sepsis
Interventions: DRUG: Lorcaserin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effects of Frozen Section Technology on Oncological and Functional Outcomes at Radical Prostatectomy.
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: PROCEDURE: NeuroSAFE procedure|PROCEDURE: Standard RARP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Role of Dietary Intake and Host Genetics in Gut Microbiome Response to Resistant Starch Consumption
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: RS2-control-RS4|DIETARY_SUPPLEMENT: RS4-control-RS2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: RFA RCT for Pancreatic or Bile Duct Cancer
Status: TERMINATED
Conditions: Unresectable Pancreatic Cancer|Cholangiocarcinoma Non-resectable
Interventions: PROCEDURE: Radiofrequency Ablation using EndoHPB Probe|PROCEDURE: Stenting only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retinal Adaptation to Intensified Insulin Therapy and Bariatric Surgery in Patients With Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus|Diabetic Retinopathy
Interventions: OTHER: Insulin pump|OTHER: Multiple daily insulin injections|PROCEDURE: Bariatric surgery|OTHER: Medical therapy for type 2 diabetes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Usability of Zubsolv Sublingual Tablets 5.7/1.4 to Suboxone Sublingual Film 8/2 In Buprenorphine/Naloxone Treated Opioid Dependent Population
Status: COMPLETED
Conditions: Opioid Dependence
Interventions: DRUG: Suboxone Sublingual Film|DRUG: Zubsolv sublingual tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SPACE: a Parent-based Treatment for Pediatric OCD
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder|Obsessive-Compulsive Disorder in Children|Obsessive-Compulsive Disorder in Adolescence|Anxiety Disorders and Symptoms
Interventions: BEHAVIORAL: Supportive Parenting for Anxious Childhood Emotions (SPACE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Solifenacin Succinate (VESIcare) for the Treatment of Urinary Incontinence in Parkinson's Disease
Status: WITHDRAWN
Conditions: Urinary Incontinence|Parkinson's Disease
Interventions: DRUG: Solifenacin Succinate (VESIcare)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Effectiveness and Safety of Shuxinin Injection in the Treatment of Acute Ischemic Stroke
Status: UNKNOWN
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Shuxinin injection|DRUG: Basic treatment|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Respiratory Training and Relaxation Techniques to Improve Adjuvant Radiation Therapy in DIBH in Breast Cancer
Status: RECRUITING
Conditions: Radiotherapy|Breast Cancer|Relaxation|Breathholding
Interventions: OTHER: Respiratory training and relaxation techniques under adjuvant radiation therapy in DIBH in breast cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TG4010 and Nivolumab in Patients With Lung Cancer
Status: COMPLETED
Conditions: Recurrent Non-Small Cell Lung Carcinoma|Stage I Non-Small Cell Lung Cancer|Stage II Non-Small Cell Lung Cancer|Stage IIIA Non-Small Cell Lung Cancer|Stage IIIB Non-Small Cell Lung Cancer|Stage IV Non-Small Cell Lung Cancer
Interventions: BIOLOGICAL: TG4010|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Newly Diagnosed Patient's With Wilm's Tumor Requiring Abdominal Radiation Delivered With Proton Beam Irradiation
Status: RECRUITING
Conditions: Wilms Tumor
Interventions: DEVICE: Proton Beam Radiation (PBRT)|DRUG: DD-4A Chemotherapy Regimen|PROCEDURE: Complete Surgical Resection|PROCEDURE: Surgical Resection|PROCEDURE: Partial Nephrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ahmed Glaucoma Valve Alone, With Amniotic Membrane or With Mitomycin C (MMC) for Treatment of Refractory Glaucoma
Status: UNKNOWN
Conditions: Refractory Glaucoma
Interventions: DEVICE: Ahmed Glaucoma Valve (AGV)|DRUG: Mitomycin C (MMC)|PROCEDURE: amniotic membrane coverage
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparison of Progestin Primed Ovarian Stimulation (PPOS) vs.GnRH Antagonist Methods on IVF Outcomes
Status: NOT_YET_RECRUITING
Conditions: IVF|Fertility Issues|Infertility
Interventions: DRUG: Progestin|DRUG: GnRH antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II/III Study of the Safety and Effectiveness of HRIG With Active Rabies Vaccine in Healthy Subjects
Status: COMPLETED
Conditions: Rabies
Interventions: DRUG: Active rabies vaccine (US-FDA approved)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Evaluate the Absorption, Distribution, Break Down and Elimination and the Safety of 14C-Labeled Tozadenant
Status: COMPLETED
Conditions: N/A, as Healthy Volunteers
Interventions: DRUG: tozadenant tablet|DRUG: C14-tozadenant capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Viruxal Oral and Nasal Spray for Treating the Symptoms of COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DEVICE: Viruxal Oral and Nasal Spray|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of High Dose Co-trimoxazole in Severe Covid-19 Patients
Status: UNKNOWN
Conditions: COVID-19 Pneumonia
Interventions: DRUG: Co-trimoxazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adaptive Non-invasive Ventilation to Abolish Tidal Flow Limitation
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|Hypercapnia|Ventilator Lung
Interventions: DEVICE: fixed-EPAP|DEVICE: auto-EPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Proton Pump Inhibitors (PPIs)
Status: TERMINATED
Conditions: Gastroesophageal Reflux Disease (GERD)
Interventions: DRUG: IW-3718|DRUG: placebo|DRUG: Standard-dose PPIs QD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Emergence Agitation in Paediatric Day Care Surgery
Status: COMPLETED
Conditions: Postoperative Delirium|Postoperative Agitation|Anesthesia|Pain Monitoring|Heart Rate Variability|Narcotrend|Mdoloris|Anesthesia Nociception Index
Interventions: DEVICE: Narcotrend bispectral index anaesthesia monitor|DEVICE: Mdoloris Anaesthesia Nociception Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Pet Therapy Applıed To Elders's Sleep And Qualıty Of Lıfe
Status: COMPLETED
Conditions: Pet Therapy Effect of Sleep and Quality of Life
Interventions: OTHER: Pet Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Methylnaltrexone Pharmacokinetics in Neurointensive Care Patients
Status: COMPLETED
Conditions: Opioid Use, Unspecified With Other Opioid-induced Disorder
Interventions: DRUG: Methylnaltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between spIgE and Skin Prick Test of Local and Imported Aeroallergens
Status: COMPLETED
Conditions: Immediate Hypersensitivity
Interventions: PROCEDURE: Skin prick test|OTHER: specific IgE measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neoadjuvant Tebentafusp for Uveal Melanoma
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Unresectable Uveal Melanoma
Interventions: DRUG: Tebentafusp-Tebn
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selexipag for the Treatment of Schistosomiasis-Associated Pulmonary Arterial Hypertension
Status: UNKNOWN
Conditions: Pulmonary Hypertension|Schistosomiasis
Interventions: DRUG: Selexipag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Prasugrel in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Prasugrel ODT1 - Tablet|DRUG: Prasugrel ODT2 - Tablet|DRUG: Prasugrel ODT2 - Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Imatinib Mesylate Plus Cytarabine in Treating Patients With Chronic Myelogenous Leukemia
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: cytarabine|DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating an Advanced Pneumatic Compression Device Versus Usual Care for Treatment of Head and Neck Lymphedema
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphedema|Lymphedema of Face|Lymphedema, Secondary|Lymphedema Due to Radiation|Lymphedema; Surgical
Interventions: DEVICE: Advanced Pneumatic Compression Device (APCD)|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Interventions for the Treatment of Early Onset Alzheimer's Disease Study
Status: RECRUITING
Conditions: Alzheimer Disease, Early Onset
Interventions: DEVICE: Cognitive Training|BEHAVIORAL: Tai Chi- Qi Gong|DEVICE: Brain Games|BEHAVIORAL: Stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Outcomes of Irrisept Irrigation as an Adjunctive Treatment in the Management of Diabetic Foot Ulcers
Status: RECRUITING
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: Irrisept|DEVICE: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT