pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pressure Controlled Ventilation Versus Volume Controlled Ventilation in Upper Abdominal Surgery
Status: COMPLETED
Conditions: Ventilator Lung
Interventions: OTHER: Starting with volume controlled ventilation and changing the ventilation mode every 20 minutes|OTHER: Starting with pressure controlled ventilation and changing the ventilation mode every 20 minutes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pre-Operative Pregabalin for Post-Operative Pain in Head and Neck Cancer Surgery
Status: WITHDRAWN
Conditions: Head and Neck Cancer|Pain, Postoperative
Interventions: DRUG: Pregabalin 150mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CLEAR Study - A Study of CellCept (Mycophenolate Mofetil) in Recipients of Kidney Transplants
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Relative Bioavailability Study
Status: COMPLETED
Conditions: Urinary Bladder, Overactive
Interventions: DRUG: tolterodine tartrate|DRUG: tolterodine tartrate|DRUG: tolterodine tartrate|DRUG: tolterodine tartrate|DRUG: tolterodine tartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Spinal Manipulation on Vulvar Pain
Status: TERMINATED
Conditions: Vulvodynia|Perineal Pain|Vulvar Pain
Interventions: OTHER: Thoracic manipulation|OTHER: Sham thoracic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A 2-Part Study to Assess Potential Metabolism-Based Drug-Drug Interactions of E2006 When Coadministered With Itraconazole, Rifampin, Midazolam, or Bupropion
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: rifampin 600 mg|DRUG: itraconazole 200 mg|DRUG: midazolam 2 mg with bupropion 75 mg|DRUG: E2006
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glasdegib in Refractory Patients With Sclerotic Chronic Graft-Versus-Host Disease
Status: UNKNOWN
Conditions: Sclerodermoid Chronic Graft-Versus-Host Disease (Disorder)
Interventions: DRUG: Glasdegib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Acetazolamide on Lung Water Content by Ultrasound in Lowlanders Older Than 40 Years at Altitude
Status: ACTIVE_NOT_RECRUITING
Conditions: Altitude Hypoxia
Interventions: DRUG: ACETAZOLAMIDE oral capsule|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Safety and Pharmacokinetics of RO6839921, An MDM2 Antagonist, in Patients With Advanced Cancers, Including Acute Myeloid Leukemia.
Status: COMPLETED
Conditions: Neoplasms, Myelogenous Leukemia, Acute
Interventions: DRUG: RO6839921|DRUG: RO6839921|DRUG: RO6839921
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of BIBW 2992 in Patients With HER2-positive Metastatic Breast Cancer After Failure of Trastuzumab Therapy
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: BIBW 2992
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Way the Body Absorbs, Distributes, Breaks Down and Eliminates Radioactive BMS-986278 in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: [14C] BMS-986278|DRUG: Kinevac®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation Of Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of Single Doses Of Vupanorsen In Japanese Healthy Adult Participants With Elevated Triglycerides
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Vupanorsen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Postoperative Nausea and Vomiting and Acupuncture/Acupressure
Status: COMPLETED
Conditions: Postoperative Vomiting|Nausea
Interventions: DEVICE: Acustimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lactobacillus Probiotic for Prevention of UTI
Status: COMPLETED
Conditions: Urinary Tract Infections (UTI's)
Interventions: DRUG: Lactobacillus crispatus CTV-05|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: PR-104 in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: PR-104|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Depo Provera Self-Administration Study: Putting a Patient-Centered Practice to the Test at Planned Parenthood
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Subcutaneous depot medroxyprogesterone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effectiveness of Adding Behavioral Therapy to Physical Therapy to Treat Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: BEHAVIORAL: Standard physical therapy|BEHAVIORAL: Graded exercise|OTHER: Graded exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Meat and Whey Protein Supplementation in Endurance Athletes
Status: UNKNOWN
Conditions: Dietary Modification
Interventions: DIETARY_SUPPLEMENT: PROTEIN|DIETARY_SUPPLEMENT: CARBOHYDRATE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Biological Therapy in Treating Patients With High-Risk Ewing's Sarcoma
Status: COMPLETED
Conditions: Sarcoma
Interventions: DRUG: cyclophosphamide|DRUG: dexrazoxane hydrochloride|DRUG: disaccharide tripeptide glycerol dipalmitoyl|DRUG: doxorubicin hydrochloride|DRUG: vincristine sulfate|PROCEDURE: surgical procedure|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy of Fractional Carbon Dioxide Laser Combined With Platelet-rich Plasma
Status: COMPLETED
Conditions: Striae Gravidarum
Interventions: PROCEDURE: Ablative fractional carbon dioxide laser combined with autologous platelet-rich plasma|DEVICE: CO2 laser with PRP|DEVICE: CO2 laser with placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Engagement in Perioperative Pain Management Project
Status: COMPLETED
Conditions: Pain, Postoperative|Opioid Use Disorder
Interventions: BEHAVIORAL: Patient Engagement Tools|BEHAVIORAL: Educational Guide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Multicenter, Adaptive, Randomized, doublE-blinded, Placebo-controlled Study in Participants With Long COVID-19: The REVIVE Trial
Status: RECRUITING
Conditions: Long COVID-19 Syndrome|Chronic Fatigue Syndrome
Interventions: DRUG: Fluvoxamine Maleate 100 MG|DRUG: Placebo|DRUG: Metformin Extended Release Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study to Evaluate the Application of NLAC Cream in Adults With Plaque Psoriasis
Status: UNKNOWN
Conditions: Plaque Psoriasis
Interventions: DEVICE: 5% Natural Lactic Acid-enriched Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Tamoxifen vs Low Dose Exemestane in Post-menopausal Women at High Risk for Breast Cancer.
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Tamoxifen 10 MG|DRUG: Exemestane 25 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate Efficacy of Two Experimental Oral Rinses in Providing Long Term Relief From Pain Derived From Exposed Dentine in Response to Chemical, Thermal, Tactile, or Osmotic Stimuli.
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: OTHER: Experimental Oral Rinse 1 (1.5% w/w KOX, 0ppm F, pH 7.0)|OTHER: Experimental Oral Rinse 2 (2.0% w/w KOX, 45ppm F, pH 4.5)|OTHER: Placebo Oral Rinse (0% w/w KOX 0ppm F, pH 4.5 )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinimetric Test of Spinal Sensors in Measuring Spinal Mobility in Axial Spondyloarthritis
Status: COMPLETED
Conditions: Ankylosing Spondylitis|Axial Spondyloarthritis
Interventions: DEVICE: ViMove Spinal Sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Romosozumab/Denosumab Study for Premenopausal IOP
Status: RECRUITING
Conditions: Premenopausal Idiopathic Osteoporosis
Interventions: DRUG: Romosozumab Prefilled Syringe [Evenity]|DRUG: Denosumab 60 MG/ML Prefilled Syringe [Prolia]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Methods for the Determination of Chromogranin A in Routine Blood Samples
Status: COMPLETED
Conditions: Neuroendocrine Carcinoma (Carcinoid)
Interventions: DRUG: Lansoprazole|DRUG: lansoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Minute Calisthenics: A Daily, Habit-Based, Bodyweight Resistance-Training Program
Status: COMPLETED
Conditions: Resistance Training
Interventions: BEHAVIORAL: Bodyweight exercises (push-ups, angled-rows, bodyweight squats) on weekdays
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Tolerability of TAR-200 mg in Subjects With Non-Muscle-Invasive Bladder Cancer
Status: COMPLETED
Conditions: Urinary Bladder Cancer
Interventions: DRUG: Gemcitabine-Releasing Intravesical System (GemRIS)/TAR-200
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of (Poly)Phenolic on Cardiometabolic Risk of Postmenopausal Women
Status: COMPLETED
Conditions: Post-menopausal Women|Overweight and Obesity
Interventions: COMBINATION_PRODUCT: (poly)phenols rich foods
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination Study of Guadecitabine/ASTX727 and Pembrolizumab
Status: RECRUITING
Conditions: Castration-Resistant Prostatic Cancer|Non Small Cell Lung Cancer
Interventions: DRUG: Guadecitabine|DRUG: Pembrolizumab|DRUG: ASTX727
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pioglitazone and Serum Asymmetric Dimethylarginine (ADMA) in Patients With Diabetes
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: Pioglitazone then Placebo|DRUG: Placebo then Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study To Evaluate Pf-04965842 In Subjects With Moderate To Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: PF-04965842|DRUG: PF-04965842|DRUG: PF-04965842|DRUG: PF-04965842|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of RVX000222 on Glucose Metabolism in Individuals With Pre-diabetes
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: RVX000222|DRUG: Placebo, RVX000222
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Calcium Supplementation on Women in the Curves for Women Program
Status: COMPLETED
Conditions: Diet Modification
Interventions: DIETARY_SUPPLEMENT: Curves Calcium|DIETARY_SUPPLEMENT: Calcium Carbonate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Automated 3D (SonoAVC) Versus 2D Ovarian Follicles Assessment in IVF Cycles: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Infertility
Interventions: OTHER: 3D follicles assessment|OTHER: 2D follicles assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Characterization of Regulatory T Lymphocytes in the Synovial Fluid of Patients Affected by Rheumatoid Arthritis.
Status: TERMINATED
Conditions: Rheumatoid Arthritis|Swelling Joint|Joint Fluid|Characterization of Regulatory T Lymphocytes
Interventions: OTHER: Exploratory synovial fluid analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Preliminary Efficacy Study of Mesenchymal Precursor Cells (MPCs) in Subjects With Lumbar Back Pain
Status: COMPLETED
Conditions: Degenerative Disc Disease
Interventions: BIOLOGICAL: Single Dose MPCs Injection|PROCEDURE: Single injection of saline solution|PROCEDURE: Single injection of hyaluronic acid|BIOLOGICAL: Single Dose MPCs Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risk of Infertility Related to Adjuvant Chemotherapy for Early Breast Cancer: Oocyte/Embryo Cryopreservation
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: PROCEDURE: Controlled ovarian hyperstimulation (COH)|PROCEDURE: Oocyte/embryo freezing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Transforming ED Throughput With AI-Driven Clinical Decision Support System
Status: COMPLETED
Conditions: Critical Care|Emergency Treatment|Triage|Readmission
Interventions: OTHER: AI-assisted models providing diagnosis and prognostic information|PROCEDURE: Critical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Post-operative Sensitivity in Composite Restorations
Status: COMPLETED
Conditions: Class II Dental Caries|Sensitivity, Tooth
Interventions: PROCEDURE: Group A ( Oblique Incremental Placement Technique)|PROCEDURE: Group B (Bulk-fill Placement technique)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical, Immunological and Microbiological Evaluation of Experimental Gingivitis and Peri-implant Mucositis
Status: COMPLETED
Conditions: Gingivitis|Mucositis
Interventions: BEHAVIORAL: Experimentally induced plaque
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety Study to Assess the Feasibility of Use in Humans of the TAXUS Petal Bifurcation Coronary Stent System
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DEVICE: Percutaneous Coronary Intervention (PCI) TAXUS Petal
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Endoscopic Surgery vs. Intensity Modulated Radiotherapy for Stage I Nasopharyngeal Carcinoma.
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma|Intensity Modulated Radiotherapy|Surgery
Interventions: PROCEDURE: Endoscopic nasopharyngectomy followed close follow-up|RADIATION: Intensity-modulated Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Aerobic Exercise and Cognitive Training in Seniors With Genetic Susceptibility for Alzheimer's Disease
Status: NOT_YET_RECRUITING
Conditions: Alzheimer Disease
Interventions: BEHAVIORAL: Combined aerobic exercise and cognitive training program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: FIrst-Pass Reperfusion With the NeVa Stent-Retriever Trial
Status: WITHDRAWN
Conditions: Acute Ischemic Stroke
Interventions: DEVICE: NeVa Stent Retrievers|DEVICE: Solitaire Stent Retrievers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Double-blind Placebo-controlled Randomized Trial Evaluating the Efficacy and Safety of a Novel HSP90 Inhibitor (RGRN-305) in the Treatment of Moderate to Severe Hidradenitis Supppurativa.
Status: COMPLETED
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: RGRN-305|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of NV-101 in Dental Patients
Status: COMPLETED
Conditions: Soft Tissue Anesthesia (Numbness)
Interventions: DRUG: NV-101 (phentolamine mesylate solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of LP-128 Capsules in Healthy Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Hepatitis b
Interventions: DRUG: LP-128 capsules|OTHER: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Activation Technique in cVEMPs
Status: COMPLETED
Conditions: Activation Technique in cVEMP Testing
Interventions: DIAGNOSTIC_TEST: Head Turn Activation Technique|DIAGNOSTIC_TEST: Head Raise Activation Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Temozolomide Phase II Clinical Study in Patients With Newly Diagnosed Glioblastoma Multiforme (Study P04661)(COMPLETED)
Status: COMPLETED
Conditions: Glioblastoma
Interventions: RADIATION: Radiotherapy|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Management Of Refractory Gastro-cutaneous Fistula After Laparoscopic Sleeve Gastrectomy l
Status: COMPLETED
Conditions: Bariatric Surgery Candidate
Interventions: PROCEDURE: endoscopic management of gastrocutaneous fistula after laparoscopic sleeve gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety, Tolerability, and Pharmacokinetics Profile in Healthy Chinese Volunteers of TG-2349
Status: COMPLETED
Conditions: Healthy Chinese Volunteers
Interventions: DRUG: Furaprevir capsule (SAD)|DRUG: Furaprevir capsule (MAD)|DRUG: Placebo (SAD)|DRUG: Placebo (MAD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of the Strategies of Switching Schizophrenia Patients to Aripiprazole From Other Antipsychotic Agents
Status: COMPLETED
Conditions: DSM-IV Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Linking High-Risk Jail Detainees to HIV Pre-Exposure Prophylaxis: PrEP-LINK
Status: COMPLETED
Conditions: HIV/AIDS|Pre-exposure Prophylaxis
Interventions: BEHAVIORAL: PrEP-LINK|OTHER: Enhanced Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Pembrolizumab in Combination With Epacadostat in Women With Recurrent/Metastatic Endometrial Carcinoma
Status: WITHDRAWN
Conditions: Recurrent/ Metastatic Endometrial Carcinoma
Interventions: DRUG: Epacadostat + pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Safety, Tolerability and PK of AZD2171 and Chemotherapy on Patients With Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumor
Interventions: DRUG: AZD2171|DRUG: FOLFOX|DRUG: Pemetrexed|DRUG: Irinotecan (administered with & without Cetuximab)|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Dose Safety Study of SRX251 Capsules in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: SRX251
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Observational Study of Avastin (Bevacizumab) in Patients With Metastatic Colorectal Cancer (ACORN)
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Bevacizumab|DRUG: Capecitabine/Oxaliplatin|DRUG: Fluorouracil/Folinic Acid/Oxaliplatin|DRUG: Capecitabine|DRUG: Fluorouracil/Folinic Acid/Irinotecan|DRUG: Fluorouracil +/- Folinic Acid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial of High Dose Lisdexamfetamine and Contingency Management in MA Users
Status: RECRUITING
Conditions: Methamphetamine Abuse|Methamphetamine-dependence|Addiction, Substance|Addiction
Interventions: DRUG: Treatment as Usual plus Placebo|DRUG: Treatment as Usual plus Placebo plus Contingency Management|DRUG: Treatment as Usual plus lisdexamfetamine (LDX-01)|DRUG: Treatment as Usual plus lisdexamfetamine (LDX-01) plus Contingency Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety & Immunogenicity of JNJ-64041757, Live-attenuated Double-deleted Listeria Immunotherapy, in Subjects With Non Small Cell Lung Cancer
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: BIOLOGICAL: JNJ-64041757 (Cohort 1A and 1B)|BIOLOGICAL: JNJ-64041757 (Cohort 2A and 2B)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Textbook Versus 3D Animation Versus Cadaveric Training Video in Teaching Laparoscopic Rectal Surgery
Status: UNKNOWN
Conditions: Educational Problems
Interventions: OTHER: to compare the educational effectiveness of various educational tools
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Safety and Efficacy Study of Human Monoclonal Antibodies, BRII-196 and BRII-198 for the Treatment of Patients With COVID-19
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: BRII-196 and BRII-198|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Maribavir Compared to Valganciclovir to Treat Cytomegalovirus Infections in People Who Have Received Stem Cell Transplants
Status: COMPLETED
Conditions: Cytomegalovirus (CMV)
Interventions: DRUG: Maribavir|DRUG: Valganciclovir|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rifapentine and Isoniazid TB Preventive Therapy (3HP) for Children Taking Dolutegravir-based Antiretroviral Treatment (DOLPHIN KIDS)
Status: RECRUITING
Conditions: Tuberculosis|HIV
Interventions: DRUG: Dolutegravir|DRUG: 3HP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Prospective Post-Market Study to Evaluate the Clinical Utility of IRIS, a Three-dimensional (3-D) Anatomical Modeling Software for Pre-operative Surgical Planning and Intra-operative Navigation for Nephrectomy
Status: COMPLETED
Conditions: Kidney Cancer
Interventions: DEVICE: IRIS 1.0
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reduce the Severity of DGF in Recipients of a Deceased Donor Kidney
Status: UNKNOWN
Conditions: Delayed Graft Function
Interventions: DRUG: ANG-3777|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Metformin Therapy on Serum Under-carboxylated Osteocalcin Levels in Hyperandrogenic Lean Polycystic Ovarian Syndrome Women
Status: UNKNOWN
Conditions: Polycystic Ovarian Syndrome
Interventions: DRUG: Metformin 850 mg twice daily for 3 months|PROCEDURE: Serum uc-oc|OTHER: drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effectiveness and Safety of Pericapsular Nerve Group (PENG) Block in Hip Fracture Patients on Antithrombotic Therapy
Status: NOT_YET_RECRUITING
Conditions: Hip Fracture|Antithrombotic Therapy|PENG Block
Interventions: PROCEDURE: PENG block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Ofatumumab and Bortezomib in Treating Patients With Previously Untreated Waldenstrom Macroglobulinemia
Status: TERMINATED
Conditions: Waldenström Macroglobulinemia
Interventions: BIOLOGICAL: ofatumumab|DRUG: bortezomib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b Proof-of-concept Trial Exploring the Effects of FE 999322 and FE 999324 in Adults With Mild to Moderate Ulcerative Colitis
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: Microbiota suspension|DRUG: Microbiota capsule|DRUG: Placebo suspension|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Serum LDL Cholesterol Concentration on Pancreatic Insulin Secretion
Status: TERMINATED
Conditions: Hypercholesterolemia|Insulin Resistance|Insulin Secretion
Interventions: DRUG: Lowering cholesterol concentrations by PCSK-9 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy Study of Switching to a Lutenizing Hormone-releasing Hormone (LHRH) Antagonist From a LHRH Agonist to Treat Progressive Castrate Resistant Prostate Cancer (CRPC)
Status: UNKNOWN
Conditions: Prostate Neoplasm
Interventions: DRUG: Degarelix
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Inecalcitol With Decitabine in Acute Myeloid Leukemia Patients Unfit for Standard Chemotherapy
Status: UNKNOWN
Conditions: Acute Myelogenous Leukemia
Interventions: DRUG: Inecalcitol|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of a Nutraceutical Supplement With Standardized Botanicals in Women With Thinning Hair
Status: COMPLETED
Conditions: Hair Thinning
Interventions: DIETARY_SUPPLEMENT: Nutrafol Supplement capsules|OTHER: Placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Dose of Artesunate Used in Combination With LAPDAP Treatment of Uncomplicated Falciparum Malaria
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Chlorproguanil-dapsone-artesunate (CDA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Penn Biobank Return of Research Results Program
Status: COMPLETED
Conditions: Cancer|Cardiovascular Diseases|Hereditary Cancer|Hereditary Cardiac Amyloidosis
Interventions: BEHAVIORAL: e-Health (web-based) disclosure portal|BEHAVIORAL: Provider mediated disclosure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Mechanical Bowel Preparation and Oral Antibiotics Versus Mechanical Bowel Preparation Only Prior Rectal Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Rectal Adenocarcinoma|Rectum Neoplasm|Rectum Carcinoma|Colorectal Cancer|Colorectal Neoplasms|Colorectal Carcinoma|Surgical Site Infection|Surgery--Complications
Interventions: DRUG: Oral Antibiotics|DRUG: Placebo|DRUG: Mechanical Bowel Preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Effect of Nasal Insulin on Postprandial Glycemic Control in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Insulin (recombinant human insulin)|DRUG: NovoLog
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Osteoclast Impairment in Chronic Periodontitis by Regenerative Materials.
Status: COMPLETED
Conditions: Periodontal Disease|Periodontal Bone Loss|Osteoclastic Bone Loss
Interventions: OTHER: other : PRF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Transcutaneous Electrical Acupoint Stimulation on Blood Pressure
Status: NOT_YET_RECRUITING
Conditions: Hypertension
Interventions: DEVICE: Transcutaneous electrical acupoint stimulation|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Duloxetine on Male Fertility
Status: COMPLETED
Conditions: Infertility, Male|Depression
Interventions: DRUG: Duloxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Infigratinib for the Treatment of Advanced or Metastatic Solid Tumors in Patients With FGFR Gene Mutations
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Cholangiocarcinoma|Metastatic Malignant Solid Neoplasm|Refractory Malignant Solid Neoplasm
Interventions: DRUG: Infigratinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Injected Ranibizumab to Treat Macular Telangiectasia With New Blood Vessel Formation
Status: COMPLETED
Conditions: Telangiectasia
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy
Status: COMPLETED
Conditions: Central Nervous System Tumor, Pediatric|Chemotherapy-induced Nausea and Vomiting|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: PROCEDURE: Real Acupressure Band|PROCEDURE: Placebo Acupressure Band
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison One vs Six Months of Dual Antiplatelet Therapy After Implanted Firehawk TM Stent in High Bleeding Risk Patients With Coronary Artery Disease
Status: UNKNOWN
Conditions: Coronary Disease|Drug Eluting Stent|Percutaneous Coronary Intervention|Dual Antiplatelet Therapy
Interventions: DRUG: 1 month DAPT|DRUG: 6 months DAPT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study With Lymfactin® in the Treatment of Patients With Secondary Lymphedema (AdeLE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Secondary Lymphedema
Interventions: DRUG: Lymfactin® (1x10E11 vp)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 5-Year Postmarketing Safety Study Of Xalcom In Patients With Open Angle Glaucoma Or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma, Open-Angle|Ocular Hypertension
Interventions: DRUG: Xalacom
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Needless Laser Injector for Antiaging Effect of Dermal Filler
Status: COMPLETED
Conditions: Aging Problems
Interventions: DEVICE: needless laser injector (Mirajet)|DEVICE: needle injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Metformin for Colorectal Cancer Risk Reduction for History of Colorectal Adenomas and Elevated BMI
Status: COMPLETED
Conditions: Adenomatous Polyp|Colorectal Cancer|Obesity
Interventions: DRUG: metformin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect Of Fesoterodine On Pharmacokinetics And Pharmacodynamics Of Warfarin In Healthy Subjects
Status: COMPLETED
Conditions: Urinary Bladder, Overactive
Interventions: DRUG: warfarin|DRUG: Warfarin plus Fesoterodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Kowa OCT Bi-μ and the Optovue iVue 100
Status: COMPLETED
Conditions: Glaucoma|Retinal Disease|Healthy
Interventions: DEVICE: KOWA OCT Bi-µ|DEVICE: Optovue iVue 100
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Coronary Non-slip Balloon Catheter in Patients With Coronary Artery Stenosis(CREST)
Status: RECRUITING
Conditions: Coronary Artery Stenosis
Interventions: DEVICE: Non-slip Balloon Catheter of Shanghai MicroPort Rhythm|DEVICE: NSE Coronary Dilatation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vascular Endothelial Growth Factor-B (VEGF-B) Blockade With the Monoclonal Antibody CSL346 in Subjects With Diabetic Kidney Disease
Status: COMPLETED
Conditions: Diabetic Kidney Disease (DKD)
Interventions: BIOLOGICAL: CSL346|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Hypnosis in Hyperemesis Gravidarum
Status: COMPLETED
Conditions: Nausea|Vomiting|Hyperemesis Gravidarum
Interventions: OTHER: Hypnosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 12 Week Study to Confirm the Effectiveness of 8mg of Fesoterodine Compared to 4mg of Fesoterodine
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: Fesoterodine 8mg|DRUG: Fesoterodine 4mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of E. Coli Isolates From Recurrent Urinary Tract Infections
Status: NOT_YET_RECRUITING
Conditions: Urinary Tract Infections|Patients With Suprabubic Catheter|Patients With Nephrostomy Catheter
Interventions: OTHER: collection of bacterial strains
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Trial of ADI-PEG 20TM in Patients With Malignant Pleural Mesothelioma
Status: UNKNOWN
Conditions: Malignant Pleural Mesothelioma
Interventions: DRUG: ADI-PEG 20
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and Plasma PK of a Single Oral Dose of Zoliflodacin in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Gonorrhoea
Interventions: DRUG: AZD0914
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Premature Infants Receiving Milking or Delayed Cord Clamping: PREMOD2
Status: COMPLETED
Conditions: Intraventricular Haemorrhage Neonatal|Death; Neonatal
Interventions: PROCEDURE: Umbilical cord milking UCM|PROCEDURE: Delayed cord clamping DCC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Carbetocin Versus Misoprostol in High Risk Patients for Postpartum Hemorrhage After C.S.
Status: UNKNOWN
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Carbetocin|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vaccine Therapy in Treating Patients With Metastatic Cancer
Status: COMPLETED
Conditions: Lung Cancer|Adult Soft Tissue Sarcoma|Colorectal Cancer|Bone Cancer|Ovarian Sarcoma|Melanoma|Colon Cancer|Rectal Cancer|Breast Cancer|Eye Cancer|Uterine Sarcoma
Interventions: DRUG: interleukin-2|DRUG: MAGE-12 peptide vaccine|DRUG: Montanide ISA-51
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effect of Mobile Online Training Applied to Patients With Diabetes on Insulin Therapy
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Health Belief Model-Based Mobile Online Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Phytosterol Esters of Omega-3 (Vayarol) Versus Omega-3 Acids Ethyl Esters in Reducing Triglyceride Levels
Status: COMPLETED
Conditions: Patients With Hypertriglyceridemia
Interventions: OTHER: Omega-3 acid ethyl esters|OTHER: Phytosterol esters of omega-3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Deferoxamine for Treating Unresectable Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma Non-resectable
Interventions: DRUG: Conventional TACE|DRUG: Deferoxamine and conventional TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Totally Transdermal Sedation in the Weaning From Remifentanil Infusion
Status: COMPLETED
Conditions: Respiratory Insufficiency|Ventilator Weaning|Analgesics, Opioid
Interventions: DRUG: Fentanyl Transdermal System|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protein Supplementation and Muscle Recovery in Football
Status: COMPLETED
Conditions: Skeletal Muscle Damage|Muscle Inflammation|Muscle Recovery|Soccer Performance
Interventions: DIETARY_SUPPLEMENT: Milk protein isolate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Food Supplement Effect on Overweight or Moderate Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: High dose|DIETARY_SUPPLEMENT: Low dose|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Effects of HSK3486 Administration on Cardiac Repolarization in Healthy Subjects
Status: RECRUITING
Conditions: Anesthesia
Interventions: DRUG: HSK3486|DRUG: Placebo|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Feasibility Study of the Percutaneous 4Tech TriCinch Coil Tricuspid Valve Repair System
Status: TERMINATED
Conditions: Functional Tricuspid Regurgitation|Heart Valve Diseases|Tricuspid Valve Insufficiency
Interventions: DEVICE: Tricinch Coil System Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor Natural Killer Cells and Aldesleukin in Treating Patients w/High Risk AML Undergoing Donor Stem Cell Transplant
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: natural killer cells|DRUG: cyclophosphamide|DRUG: fludarabine phosphate|PROCEDURE: allogeneic hematopoietic stem cell transplantation|RADIATION: total body irradiation|BIOLOGICAL: Thymoglobulin|DRUG: Cyclosporin A|DRUG: cyclophosphamide|DRUG: fludarabine phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Sulfur Thermal Water Inhalation on Airway Oxidative Stress in COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: OTHER: Sulfur Thermal water|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dexamethasone as Analgesic Treatment After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Dexamethasone|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metformin and Nightly Fasting in Women With Early Breast Cancer
Status: RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Breast Ductal Carcinoma In Situ|Invasive Breast Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Extended Release Metformin Hydrochloride|OTHER: Monitoring|OTHER: Nutritional Assessment|OTHER: Short-Term Fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Perineural Local Anesthetic Administration With a Continuous Infusion Versus Automatic Intermittent Boluses
Status: COMPLETED
Conditions: Pain, Acute|Anesthesia, Local|Trauma Injury
Interventions: DEVICE: Continuous Infusion|DEVICE: Automated Intermittent Boluses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Permanent Occlusion of Uteine Arteies in Management of Abnormal Uterine Bleeding
Status: COMPLETED
Conditions: Other Abnormal Uterine and Vaginal Bleeding
Interventions: PROCEDURE: bilateral permanent occlusion of uterine arteries
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT