pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Single Arm, Phase II Study of Simvastatin Plus XELOX and Bevacizumab as First-line Chemotherapy in Metastatic Colorectal Cancer Patients
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of High Dose Liposomal Amphotericin B Efficacy in Initial Zygomycosis Treatment
Status: COMPLETED
Conditions: Zygomycosis
Interventions: DRUG: Liposomal Amphotericin B
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain
Status: COMPLETED
Conditions: Acute Pain|Chronic Pain|Hernia|Anesthesia, Intravenous|Anesthesia, Intratracheal
Interventions: DRUG: Propofol|DRUG: Sevoflurane|DRUG: Remifentanil|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Randomized Evaluation of Machine Learning Assisted Radiation Treatment Planning vs Standard Radiation Treatment Planning
Status: RECRUITING
Conditions: Cancer Head Neck|Cancer, Head|Cancer Neck
Interventions: RADIATION: Machine Learning Assisted Radiation (MLAP) RapidPlan|RADIATION: Radiation Therapy Standard of Care (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Analgesia Based Sedation Protocol on Brain Function of Critical Care Patients
Status: UNKNOWN
Conditions: Delirium
Interventions: DRUG: Fentanyl|DRUG: Remifentanil|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Low-dose Statins and Nutraceuticals in High-intensity Statin-intolerant Patients
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: Association low-dose statin and nutraceuticals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Diaphragmatic Breathing and Global Postural Reeducation on Stress and Sleep Quality in University Students
Status: NOT_YET_RECRUITING
Conditions: Stress|Sleep Disturbance
Interventions: OTHER: Diaphragmatic Breathing|OTHER: Global Postural Reeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ultrasound-guided Erector Spinae Plane Block on Postoperative Pain and Sleep Quality of Infants With Congenital Pulmonary Cystic Disease After Thoracoscopic Surgery
Status: RECRUITING
Conditions: Cystic Adenomatoid Malformation of Lung, Congenital|Bronchopulmonary Sequestration|Bronchogenic Cyst
Interventions: DRUG: Ropivacaine|PROCEDURE: erector spinae plane block|PROCEDURE: Incision infiltration of local anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Modality Therapy With Growth Factor Support in Locally Advanced Non-small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Unresectable Locally Advanced NSCLC
Interventions: DRUG: Cisplatin; Etoposide; Radiation therapy; Docetaxel; Neulasta
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Extracorporeal CO2 Removal in Stable Hypercapnic COPD Patients
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease Patients|Chronic Respiratory Failure
Interventions: DEVICE: extracorporeal CO2 device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Preliminary Effects of a Spiritual Care Strategy on Psychological Disorders in Critically Ill Patients
Status: NOT_YET_RECRUITING
Conditions: Psychological Disorder|Critical Illness
Interventions: BEHAVIORAL: Program of systematic and periodic spiritual accompaniment and care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Topical Calcipotriol /Betamethasone Ointment in the Treatment of Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis Vulgaris|Fractional CO2 Laser
Interventions: DRUG: Topical Ointment containing Calcipotriol 0.05 mg/gm and Betamethasone dipropionate 0.5 mg/gm|DEVICE: Fractional carbon dioxide (CO2) laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Laser Activated Irrigation Versus Passive Ultrasonic Irrigation
Status: UNKNOWN
Conditions: Pulp Necroses
Interventions: DEVICE: Laser activated irrigation|DEVICE: Passive ultrasonic irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protective Effects of EPI-743 on Noise-Induced Hearing Loss
Status: COMPLETED
Conditions: Noise-induced Hearing Loss
Interventions: DRUG: EPI-743|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal in ICU Setting
Status: COMPLETED
Conditions: Penicillin Allergy
Interventions: OTHER: Penicillin Allergic Risk Stratification Best Practice Alert
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interventions for Residual Dizziness After Successful Repositioning Maneuvers in Patients With BPPV
Status: UNKNOWN
Conditions: Vestibular Disorder
Interventions: DRUG: Betahistine|BEHAVIORAL: Exercise-based vestibular rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adapting a Low-cost Intimate Partner Violence and Mental Health Response Intervention
Status: RECRUITING
Conditions: Violence, Domestic|Psychological Distress
Interventions: BEHAVIORAL: WINGS+PM+|BEHAVIORAL: PM+-only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Agonists of Glucagon Like Peptide - 1 Receptors (GLP-1R) on Arterial Stiffness, Endothelial Glycocalyx and Coronary Flow Reserve in Patients With Coronary Artery Disease and Patients With Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Coronary Artery Disease
Interventions: DRUG: Liraglutide|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Acceptance of Changes in Medical Supervision of Exercise Groups in Cardiac Rehabilitation
Status: COMPLETED
Conditions: Cardiac Rehabilitation|Rehabilitation Exercise|Organization and Administration|Feasibility Studies
Interventions: PROCEDURE: Version 1: Paramedic|PROCEDURE: Version 2: Physician-on-call|PROCEDURE: Version 3: Trained instructor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pharmacokinetics and Safety of Oral Posaconazole (MK-5592)Tablets in Chinese Participants at High Risk for Invasive Fungal Infections (MK-5592-117)
Status: COMPLETED
Conditions: Fungal Infection
Interventions: DRUG: Posaconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Food Structure and Satiety
Status: WITHDRAWN
Conditions: Appetitive Behavior
Interventions: COMBINATION_PRODUCT: Nano-particulated whey protein vs non-particulated whey protein (control)|COMBINATION_PRODUCT: High molecular weight whey protein-alginate coacervates vs calcium alginate (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transcranial Direct Current Stimulation (tDCS) as a Treatment for Cognitive Deficits in Schizophrenic
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DEVICE: tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of SBR759 in Lowering Serum Phosphate Levels in Chronic Kidney Disease Patients on Hemodialysis
Status: COMPLETED
Conditions: Hyperphosphatemia Patients With Chronic Kidney Disease on 3x/Week Replacement Therapy
Interventions: DRUG: SBR759|DRUG: Sevelamer HCl|DRUG: SBR759|DRUG: Sevelamer HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Treprostinil in Participants With Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease (PH-COPD)
Status: TERMINATED
Conditions: Pulmonary Hypertension|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Inhaled treprostinil solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acalabrutinib and Rituximab in Elderly Patients With Untreated Mantle Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: MCL|Mantle Cell Lymphoma
Interventions: DRUG: Acalabrutinib-rituximab in patients with untreated mantle cell lymphoma
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Total Gastrectomy With Versus Without Bursectomy
Status: UNKNOWN
Conditions: Laparoscopic Gastrectomy|Laparoscopic Bursectomy|A Left Outside Bursa Omentalis Approach
Interventions: PROCEDURE: Laparoscopic D2 radical total gastrectomy with bursectomy using a left outside bursa omentalis approach|PROCEDURE: Laparoscopic D2 radical total gastrectomy without bursectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Long-Term Safety and Efficacy of Lebrikizumab (LY3650150) in Participants 6 Months to <18 Years of Age With Moderate-to-Severe Atopic Dermatitis
Status: ENROLLING_BY_INVITATION
Conditions: Atopic Dermatitis|Eczema
Interventions: DRUG: Lebrikizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Tolerability of MTS in Children Aged 6-12 Diagnosed With ADHD & Previously Treated With Extended-Release Methylphenidate Therapy
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: Methylphenidate Transdermal System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CLLR3: Bendamustine + GA101 (BG) in Relapsed or Refractory CLL Followed by GA101 Maintenance for Responding Patients
Status: UNKNOWN
Conditions: Chronic Lymphocytic Leucemia
Interventions: BIOLOGICAL: GA101 (Obinutuzumab)|DRUG: Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Narsoplimab in Pediatric Patients With High-Risk Hematopoietic Stem Cell Transplant TMA
Status: RECRUITING
Conditions: Thrombotic Microangiopathies|Hematopoietic Stem Cell Transplantation
Interventions: DRUG: Biological: narsoplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pyrotinib in Metastatic HER2 Non-amplified But HER2 Mutant Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer|HER2 Gene Mutation
Interventions: DRUG: Pyrotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Evaluate Biomarker Change, Efficacy, Pharmacokinetics, Safety and Tolerability of Telacebec (Q203) in Covid-19 Patients
Status: TERMINATED
Conditions: COVID-19 Virus Infection
Interventions: DRUG: Telacebec|DRUG: COVID-19 Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Dysphagia Associated With Anterior Cervical Spine Surgery by Maintaining Low Endotracheal Tube Cuff Pressure
Status: COMPLETED
Conditions: Deglutition Disorders
Interventions: PROCEDURE: Maintaining low (15mmHg) ETT cuff pressure|PROCEDURE: Maintaining a normal pressure in the ETT cuff
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study on the Effect of Prostacyclin Compared to Placebo in Traumatic Brain Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: DRUG: epoprostenol versus normal saline|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Evaluate Pregabalin and Acetaminophen Compared to Acetaminophen and Placebo in Subjects Undergoing Bunionectomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Pregabalin|DRUG: Acetaminophen|OTHER: Placebo 1|OTHER: Placebo 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Subcutaneous Nitroglycerin for Pediatric Radial Artery Cannulation
Status: COMPLETED
Conditions: Arterial Line
Interventions: DRUG: Nitroglycerin|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate ITCA 650 Compared to Glimepiride for the Treatment of Type 2 Diabetes
Status: WITHDRAWN
Conditions: Type 2 Diabetes
Interventions: DRUG: ITCA 650 60 mcg/day|DRUG: glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colonoscopic Removal of Aberrant Crypt Foci: a Prospective, Randomized, Blinded Trial
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: PROCEDURE: Surgical removal of ACF|PROCEDURE: Colonoscopic evaluation only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Spinal Manipulation Therapy or Mindfulness-based Reduction Therapy on Patients With Chronic Low Back Pain
Status: RECRUITING
Conditions: Chronic Low-back Pain
Interventions: OTHER: Spinal Manipulation Therapy (SMT)|DRUG: Naloxone|DRUG: Placebo|BEHAVIORAL: Mindfulness Based Stress Reduction Therapy (MT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Distraction-rotation Knee Unloader Brace in Patients With Medial Knee Osteoarthritis.
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: PROTEOR Internal unicompartmental knee brace
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selective Complex Fractionated Atrial Electrograms (CFAE) Targeting for Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: CFAE ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Role of Oral Steroids in Reducing Recurrence of Urethral Stricture After Direct Vision Internal Urethrotomy
Status: COMPLETED
Conditions: Recurrence
Interventions: DRUG: Steroid Drug|DRUG: No steroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Arm Circumference Measurement With or Without Bioimpedance Spectroscopy in Finding Lymphedema Early in Patients With Stage I-III Breast Cancer
Status: TERMINATED
Conditions: Lymphedema|Breast Cancer
Interventions: PROCEDURE: arm circumference measurement|DEVICE: Bioimpedance spectroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study Comparing Three Strategies to Switch Patients With Schizophrenia or Schizoaffective Disorder to Risperidone After Unsuccessful Treatment With Olanzapine.
Status: COMPLETED
Conditions: Schizoaffective Disorder|Schizophrenia
Interventions: DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Test The Effect Of GW786034 (Pazopanib) On P450 Enzymes
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: GW786034 (pazopanib)|DRUG: Probe drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Absorption, Metabolism, and Excretion of [14C]-BGB-3111 in Healthy Males
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: [14C]-BGB-3111|DRUG: BGB-3111
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Oxytocin at Elective Cesarean Deliveries: A Dose-finding Study in Women With BMI ≥ 40kg/m2
Status: COMPLETED
Conditions: Postpartum Hemorrhage|Obesity
Interventions: DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of Rigid Sternal Fixation in Supporting Bone Healing and Improving Postoperative Recovery
Status: COMPLETED
Conditions: Coronary Artery Disease|Angina Pectoris|Cardiac Valve Disease
Interventions: DEVICE: SternaLock Blue closure system|DEVICE: Suture Wire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Safety of Thoracentesis, Tunneled Pleural Catheter, and Chest Tubes in Patients Taking Novel Oral Anti-Coagulants
Status: COMPLETED
Conditions: Pleural Effusion|Thoracic Effusion
Interventions: DRUG: Novel Oral Anti-Coagulants
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reducing Symptom Burden - Non Small Cell Lung Cancer (NSCLC)
Status: WITHDRAWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Armodafinil|DRUG: Bupropion|DRUG: Minocycline|DRUG: Curcumin|BEHAVIORAL: Telephone Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dysfunctional Uterine Bleeding After Tubal Sterilization
Status: RECRUITING
Conditions: Contraception|Dysfunctional Uterine Bleeding
Interventions: PROCEDURE: Pomeroy's tubal sterilization|PROCEDURE: Salpingectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ensartinib as Adjuvant Treatment in Anaplastic Lymphoma Kinase (ALK) Positive Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Ensartinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study for the Treatment of Intermittent Allergic Rhinitis With Desloratadine (Study P04683)
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal|Rhinitis, Allergic, Perennial
Interventions: DRUG: 5-mg Desloratadine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery
Status: RECRUITING
Conditions: Tonsillitis|Post-operative Nausea and Vomiting (PONV)|Emergence Delirium|Opioid Analgesic Adverse Reaction|Anesthesia|Pain
Interventions: DRUG: Dexmedetomidine|DRUG: Acetaminophen|DRUG: Ketorolac|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-368 Plus Tilsotolimod and Other Therapy Combinations in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Advanced Solid Tumors Cancer
Interventions: DRUG: ABBV-368|DRUG: Tilsotolimod|DRUG: Nab-paclitaxel|DRUG: ABBV-181
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Isosorbide Mononitrate in Reducing Time in Induction of Labor in Post Date Women
Status: UNKNOWN
Conditions: Induction of Labor
Interventions: DRUG: Isosorbide mononitrate|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Preoperative Inspiratory Muscle Training (IMT) in Obese Women Undergoing Open Bariatric Surgery
Status: COMPLETED
Conditions: Preoperative Inspiratory Muscular Training|Bariatric Surgery|Chest Physiotherapy|Postoperative Pulmonary Complications|Obesity
Interventions: OTHER: Inspiratory muscular training - IMT
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Combination Chemotherapy Before and After Surgery in Treating Patients With Stomach Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: cisplatin|DRUG: floxuridine|DRUG: fluorouracil|DRUG: leucovorin calcium|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Macugen to Prevent Worsening of Macular Edema Following Cataract Surgery in Diabetics
Status: TERMINATED
Conditions: Cystoid Macular Edema
Interventions: DRUG: Pegaptanib sodium|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-inferiority Phase III Trial Comparing Dapaconazole Cream 2% With Ketoconazole Cream 2% in Patients With Tinea Pedis
Status: WITHDRAWN
Conditions: Tinea Pedis
Interventions: DRUG: Dapaconazole|DRUG: Ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lose 2 Win A Novel Method to Motivate Weight Loss Maintenance Among College Students
Status: COMPLETED
Conditions: Overweight|Obese
Interventions: BEHAVIORAL: Bi-weekly in person meetings with a Registered Dietician|BEHAVIORAL: Financial incentives for weight loss maintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CP-690-550 Ointment For Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: CP-690,550 Ointment 1|DRUG: Vehicle 1|DRUG: CP-690,550 Ointment 2|DRUG: Vehicle 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Pressurized Intraperitoneal Aerosol Chemotherapy to Prevent Colorectal Peritoneal Metastases (ProphyPIPAC)
Status: RECRUITING
Conditions: Peritoneal Metastases From Colorectal Cancer
Interventions: PROCEDURE: Pressurized intraperitoneal aerosol chemotherapy (PIPAC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Memantine Augmentation of Targeted Cognitive Training in Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Memantine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Absorptive Clearance After Inhaled Osmotics in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: hypertonic saline (7%)|DRUG: isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Idasanutlin With Cytarabine Versus Cytarabine Plus Placebo in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML)
Status: TERMINATED
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: Cytarabine|DRUG: Idasanutlin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Glecaprevir/Pibrentasvir (ABT-493/ABT-530) in Treatment-Naive and Treatment-Experienced, Non-Cirrhotic Asian Adults With Chronic Hepatitis C Virus Genotype (GT) 1 to GT6 Infection With or Without Human Immunodeficiency Virus Co-Infection
Status: COMPLETED
Conditions: Hepatitis C Virus (HCV)
Interventions: DRUG: Placebo|DRUG: Glecaprevir/Pibrentasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study on the Infusion of ARI-0001 Cells in Patients With CD19+ Leukemia or Lymphoma Refractory to Therapy
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: BIOLOGICAL: Adult differentiated autologous T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: This is a Study to Evaluate the Safety and Tolerability of the Study Drug ABL001, and to Determine the Maximum Tolerated Dose and/or Recommended Phase 2 Study Dose of ABL001
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: NOV1501 (ABL001)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Locally Delivered Allogeneic Mesenchymal Stromal Cells
Status: RECRUITING
Conditions: Mesenchymal Stromal Cells|Cornea|Safety|Corneal Defect
Interventions: BIOLOGICAL: Allogeneic MSC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modafinil and Cognitive Function in POTS
Status: ACTIVE_NOT_RECRUITING
Conditions: Postural Tachycardia Syndrome
Interventions: DRUG: Placebo|DRUG: Modafinil|DRUG: Propranolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glucose Variability in Patients With Type 1 Diabetes With a Sucrose-added Diet
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: OTHER: Control diet|OTHER: Test Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Analgesic Effect of Dexmedetomidine Versus Fentanyl as Adjuvants to Epidural Bupivacaine in Patients Undergoing Lumbar Spine Surgeries
Status: COMPLETED
Conditions: Dexmedetomidine VS Fentanyl as Adjuvants to Epidural Bupivacaine in Patients Undergoing Lumbar Spine Surgeries
Interventions: DRUG: Dexmedetomidine|DRUG: Bupivacaine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients
Status: RECRUITING
Conditions: Tuberculosis, MDR
Interventions: DRUG: Delamanid (DLM)|DRUG: Isoniazid (INH)|DIETARY_SUPPLEMENT: Pyridoxine (vitamin B6)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Single-dose, Dose-escalation Study of Safety, PK, and Preliminary Efficacy of XOMA 052 in Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: XOMA 052|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Pharmacokinetics of Intravenous Administered 14C-MNTX
Status: COMPLETED
Conditions: Healthy Male Volunteers
Interventions: DRUG: IV methylnaltrexone (MNTX)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Asthma and Technology in Emerging African American Adults
Status: RECRUITING
Conditions: Asthma
Interventions: BEHAVIORAL: Motivational Enhancement System (MES)|BEHAVIORAL: Supportive Accountability (SA)|BEHAVIORAL: Text Messaging (SMS)|BEHAVIORAL: Physical Activity Tracking (PAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adapting and Evaluating a Brief Advice Tobacco Intervention in High-Reach, Low-Resource Settings in India
Status: RECRUITING
Conditions: Tobacco Use Cessation
Interventions: BEHAVIORAL: LifeFirst SWASTH brief advice intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effect of Lidocaine and Adrenaline Soaked Gauze Versus Normal Saline Soaked at Skin Graft Donor Site of Thigh
Status: COMPLETED
Conditions: Non-healing Wound
Interventions: DRUG: 2% Lidocaine and 1:100,000 Adrenaline|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Drug Safety and Dose-exploratory Clinical Study of Azvudine Tablets in Patients Who Have Not Received Anti-HIV Treatment
Status: COMPLETED
Conditions: AIDS
Interventions: DRUG: The subjects were randomized to the treatment group of 3TC or different doses of FNC. The background drugs were EFV and TDF.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Alcohol and Steroid Injection for Treating Morton's Neuroma
Status: UNKNOWN
Conditions: Morton's Neuroma
Interventions: DRUG: Injection of Steroid into Foot|DRUG: Injection of Alcohol into Foot|DRUG: Injection of Lidocaine into Foot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of QAW039 in Patients With Severe Asthma Inadequately Controlled With Standard of Care Asthma Treatment.
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: QAW039|DRUG: QAW039|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aripiprazole Oral Solution in the Treatment of Children and Adolescents With Tourette's Syndrome
Status: COMPLETED
Conditions: Tourette Syndrome
Interventions: DRUG: Aripiprazole Oral Solution|DRUG: Placebo Oral Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Omalizumab (Xolair) on Basophils in Patients With Chronic Idiopathic Urticaria
Status: COMPLETED
Conditions: Chronic Urticaria
Interventions: DRUG: Omalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Ventricular Arrhythmia in Subjects With Implantable Cardioverter Defibrillator or Cardiac Resynchronization Therapy-Defibrillator
Status: COMPLETED
Conditions: Ventricular Arrhythmia
Interventions: DRUG: Eleclazine|DRUG: Placebo to match eleclazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study With Cabazitaxel in Combination With Daily Prednisolone in Patients With Hormone Refractory Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Cabazitaxel (XRP6258)|DRUG: prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dabrafenib With Trametinib in the Adjuvant Treatment of High-risk BRAF V600 Mutation-positive Melanoma (COMBI-AD).
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Dabrafenib|DRUG: Trametinib|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Efficacy of a New Influenza Candidate Vaccine MVA-NP+M1 In Healthy Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: MVA-NP+M1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prospective, Multi-center Study to Assess Posterolateral Fusion Using FIBERGRAFT
Status: COMPLETED
Conditions: Degenerative Disc Disease|Spondylolisthesis|Spinal Stenosis Lumbar
Interventions: DEVICE: FIBERGRAFT BG Matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Conservative Treatment of Distal Radius Fracture in Elderly in Randomized Controlled Trial
Status: COMPLETED
Conditions: Colles' Fracture|Distal Radius Fracture
Interventions: OTHER: Flexion-ulnar cast|OTHER: Functional cast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Analgesic Efficacy of Δ9-THC (Namisol®) in Patients With Persistent Postsurgical Abdominal Pain
Status: COMPLETED
Conditions: Postsurgical Pain|Abdominal Pain|Chronic Pain
Interventions: DRUG: Tetrahydrocannabinol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Different Exercise Training Programs to the Profile of COPD Patients
Status: COMPLETED
Conditions: Obstructive Chronic Pulmonary Disease|Emphysema
Interventions: OTHER: Endurance training|OTHER: Strength training|OTHER: Combined training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gene Therapy in Subjects With Biallelic RPE65 Mutation-associated Retinal Dystrophy
Status: RECRUITING
Conditions: Biallelic RPE65 Mutation-associated Retinal Dystrophy
Interventions: GENETIC: FT-001 Low Dose|GENETIC: FT-001 Mid Dose|GENETIC: FT-001 High Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Effectiveness and Economical Impact of Medical Indoor Environment Counselors Visiting Homes of Asthma Patients
Status: COMPLETED
Conditions: Asthma
Interventions: OTHER: First home intervention with advice|OTHER: First home intervention without any advice|OTHER: Final home visit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intensive Pharmacokinetics of the Nelfinavir-Rifabutin Interaction in Patients With HIV-Related Tuberculosis Treated With a Rifabutin-Based Regimen
Status: UNKNOWN
Conditions: Tuberculosis|HIV Infections
Interventions: DRUG: rifabutin|DRUG: isoniazid|DRUG: efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Efficacy and Satisfaction of the Skinceuticals Skin Care Product (CE) for Skin Repair Post Fraxel Laser Treatment
Status: NOT_YET_RECRUITING
Conditions: Photo-damaging
Interventions: OTHER: Skinceuticals skin care product(CE)|OTHER: fraxel laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Transcutaneous Trigeminal Nerve Stimulation for Prevention of Cerebral Vasospasm After Subarachnoid Haemorrhage
Status: COMPLETED
Conditions: Subarachnoid Haemorrhage (SAH)
Interventions: DEVICE: Transcutaneous Electrical Nerve Stimulation (TENS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optimization of a Mobile Transdiagnostic Emotion Regulation Intervention for University Students
Status: COMPLETED
Conditions: Emotion Regulation|Stress|Depressive Symptoms|Anxiety
Interventions: BEHAVIORAL: Transdiagnostic emotion regulation intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cabozantinib and Panitumumab to Treat KRAS Wild-Type Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: Panitumumab|DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hepatic Arterial Infusion of Melphalan With Hepatic Perfusion in Treating Patients With Unresectable Liver Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: isolated perfusion|DRUG: melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of the Mirror Therapy for Improving Bimanual Performance, Somatosensory Function of the Impaired Upper Limb and Quality of Life in Children With Unilateral Spastic Cerebral Palsy
Status: ENROLLING_BY_INVITATION
Conditions: Hemiplegic Cerebral Palsy|Mirror Movement Therapy
Interventions: OTHER: Mirror Therapy|OTHER: Program without Mirror Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erlotinib Hydrochloride in Treating Patients With Malignant Peritoneal Mesothelioma
Status: COMPLETED
Conditions: Malignant Peritoneal Mesothelioma
Interventions: DRUG: erlotinib hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of an Additional Pre-extubational Loading Dose of Caffeine-citrate
Status: RECRUITING
Conditions: Apnea of Prematurity|Premature Birth|Respiratory Failure
Interventions: DRUG: Caffeine citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chlorhexidine Gel Versus Alvogyl Following Surgical Extraction of Impacted Mandibular Third Molar
Status: COMPLETED
Conditions: Impacted Third Molar Tooth
Interventions: DRUG: Alvogyl|DRUG: Chlorhexidine Gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Functional Inspiratory Muscle Training in Obese Individuals
Status: RECRUITING
Conditions: Obesity
Interventions: OTHER: Functional Inspiratory Muscle Training|OTHER: Aerobic+Resistive Exercise Traning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Administration of a Prokinetic for Bowel Evacuation in Persons With SCI
Status: COMPLETED
Conditions: SCI
Interventions: DRUG: IN NEO|DRUG: IN NEO|DRUG: IN NEO|DRUG: IN NEO + IN Glycopyrrolate|DRUG: IV Visit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brentuximab Vedotin as Consolidation Treatment in Patients With Stage I/II HL and PET Positivity After 2 Cycles of ABVD
Status: COMPLETED
Conditions: Hodgkin Lymphoma
Interventions: DRUG: brentuximab vedotin|DRUG: Cyclophosphamide|DRUG: Adriamycin|DRUG: Oncovin|DRUG: Bleomycin|DRUG: Etoposide|DRUG: Procarbazine|DRUG: Prednisone|DRUG: G-CSF|RADIATION: 30 Grays
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atrial Fibrillation Lifestyle Project
Status: UNKNOWN
Conditions: Atrial Fibrillation Paroxysmal
Interventions: BEHAVIORAL: Risk Factor Management Consult|BEHAVIORAL: Diet Classes|BEHAVIORAL: Stress Management Classes|OTHER: Exercise Classes|OTHER: Home based exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy and Tolerability of Micardis® / MicardisPlus® Under Usual Daily-practice Prescribing in Patients With Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan|DRUG: Telmisartan in combination with hydrochlorothiazide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of External Neuromuscular Electrical Stimulation in Women With Urgency Urinary Incontinence
Status: COMPLETED
Conditions: Physiotherapy|Women's Health|Urge Incontinence|Electrical Stimulation
Interventions: DEVICE: Electrotherapy|DEVICE: Sham Electrotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Finger Puppet, Abeslang Puzzle, and Pinwheel on Pain and Anxiety During Blood Sampling Procedures
Status: COMPLETED
Conditions: Pain, Acute|Anxiety|Child, Only
Interventions: OTHER: PFA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Enteric-Coated Mycophenolate Sodium (EC-MPS) in Renal Transplant Patients
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: Enteric-Coated Mycophenolate Sodium (EC-MPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessment and Treatment for Chronic Pain in Veterans With Serious Mental Illness
Status: RECRUITING
Conditions: Chronic Pain|Schizophrenia|Psychotic Disorders|Bipolar Disorder|Affective Disorders, Psychotic
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Chronic Pain|BEHAVIORAL: Health and Wellness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Views and Attitudes of Oncologists and Geriatricians on the Use of Chemotherapy and Hormone Therapy in Treating Older and/or Frail Women With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: survey administration
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Randomized, Double Masked, Clinical Study of Subjects With Dry Eye Syndrome
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: ADX-102 Ophthalmic Solution (0.5%)|DRUG: ADX-102 Ophthalmic Solution (0.1%)|DRUG: ADX-102 Ophthalmic Lipid Solution (0.5%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: ACT for Life: a Brief Intervention for Maximizing Recovery After Suicidal Crises
Status: COMPLETED
Conditions: Suicide|Psychiatric Rehabilitation
Interventions: BEHAVIORAL: ACT for Life|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinician Promotion of Healthy Diet and Activity to Reduce Obesity Among Adolescents: HEALTHY SMILES
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Obesity Prevention|BEHAVIORAL: Tobacco Prevention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optical Coherence Tomography Guided Percutaneous Coronary Intervention With Stent Implantation
Status: COMPLETED
Conditions: Coronary Artery Disease|Myocardial Infarction
Interventions: DEVICE: Percutaneous coronary intervention with Nobori biolimus-eluting stent implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT