pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Adult B-ALL Treated by CART Cell Bridging Allogeneic Hematopoietic Stem Cell Transplantation
Status: UNKNOWN
Conditions: Adult B Acute Lymphoblastic Leukemia
Interventions: DRUG: CD19 CAR-T|DRUG: CD22 CAR-T|DRUG: CD19+CD22 CAR-T|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Tobacco-related Biomarkers of Exposure in Smokers Using myBlu E-cigarettes
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: Continue-smoking|OTHER: myblu Tobacco 2.5%|OTHER: myblu Tobacco 4.0%|OTHER: myblu Honeymoon 2.5%|OTHER: myblu Honeymoon 4.0%|OTHER: JUUL 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Gut-Brain Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism Spectrum Disorder (ASD)|Gastro-Intestinal Disorder
Interventions: BIOLOGICAL: FMT versus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phototherpy Versus Tapwater Iontophoresis for Management of Atopic Dermatitis in Children.
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DEVICE: Ultra Violet A Device.+ Topical medical treatment|DEVICE: Iontophoresis device + Topical medical treatment|DRUG: Topical medical treatment (Betamethasone dipropionate 0.05% " diprolene " )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Clinical Response to Acute Metformin By Leveraging Evaluations During a Mixed Meal Tolerance Test for Exploring Glycemia and GeneticS
Status: ACTIVE_NOT_RECRUITING
Conditions: Genetics|Metabolism|Type 2 Diabetes
Interventions: OTHER: Mixed Meal Tolerance Test|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Local Anesthesia for Inguinal Hernia Surgery in Older Adults
Status: RECRUITING
Conditions: Inguinal Hernia|Anesthesia, Local
Interventions: OTHER: Open Inguinal Hernia Repair - Local Anesthesia|OTHER: Inguinal Hernia Repair - General Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate if the Uptake of Ticagrelor Into the Body Differs Depending on Method of Administration.
Status: COMPLETED
Conditions: Bioavailability Heathy Volunteers
Interventions: DRUG: Ticagrelor 90 mg whole tablet|DRUG: Ticagrelor 90 mg tablet crushed|DRUG: Dispersed ticagrelor 90 mg tablet suspended in water - nasogastric tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Does 3D Visualisation Improve Performance of Laparoscopic Cholecystectomy by Junior Surgeons?
Status: COMPLETED
Conditions: Complication Laparoscopic Cholecystectomy|Conversion Laparoscopic to Open Cholecystectomy
Interventions: PROCEDURE: 3D laparoscopic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of the Low-level Laser Therapy on Functional Capacity of the Patients With Coronary Artery Bypass Surgery
Status: UNKNOWN
Conditions: Cardiovascular Diseases
Interventions: DEVICE: Sham Low-Level Laser Therapy (Sham LLLT)|DEVICE: 6J Low-Level Laser Therapy (6J LLLT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bilateral Transversus Abdominis Plane Block With or Without Magnesium
Status: TERMINATED
Conditions: Pain, Postoperative
Interventions: DRUG: Magnesium Sulfate|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Augmented Macular Pigment-containing Nutraceutical and Central Visual Function
Status: WITHDRAWN
Conditions: Glaucoma|Glaucoma Eye|Glaucoma, Open-Angle
Interventions: DIETARY_SUPPLEMENT: Lumega-Z|DRUG: Dorzolamide Hcl 2% Oph Soln|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Buttermilk on Cholesterol Concentration and Homeostasis
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: OTHER: Buttermilk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: L. Reuteri DSM 17938 and L. Reuteri ATCC PTA 6475 in Moderate to Severe Irritable Bowel in Adults
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: L. reuteri DSM 17938 and L. reuteri ATCC PTA 6475|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prebiotics for Spinal Cord Injury Patients With Bowel and Bladder Dysfunction
Status: COMPLETED
Conditions: Spinal Cord Injuries|Neurogenic Bowel|Bladder Dysfunction
Interventions: DIETARY_SUPPLEMENT: Human Milk Oligosaccharides (HMO)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Strategies of Revascularization in Patients With ST-segment Elevation Myocardial Infarction (STEMI) and Multivessel Disease
Status: UNKNOWN
Conditions: Myocardial Infarction|Angioplasty, Transluminal, Percutaneous Coronary|Echocardiography, Stress
Interventions: PROCEDURE: complete multivessel revascularization|PROCEDURE: stress echocardiography and revascularization if required
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: At Home Gamma tACS in Alzheimer's Disease (tACS@Home)
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DEVICE: 40 Hz transcranial alternating current stimulation|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone on Morbidity (Events Indicating Disease Worsening) & Mortality (Death Rate) in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40%
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Finerenone (BAY94-8862)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Histone Deacetylase Inhibitor LBH589 in Addition to Corticosteroids in Patients With Acute Graft Versus Host Disease (GVHD)
Status: COMPLETED
Conditions: Graft-Versus-Host Disease
Interventions: DRUG: Panobinostat (LBH589)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Theta-burst Stimulation Efficacy, Safety and Tolerability in Major Depressive Episodes of Bipolar I Disorder
Status: UNKNOWN
Conditions: Bipolar Disorder, Type 1
Interventions: DEVICE: Active Theta Burst Stimulation (TBS)|DEVICE: Sham Theta Burst Stimulation (TBS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Dosed of HSK36273 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HSK36273|DRUG: Placebo|DRUG: Heparin sodium injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Improving Rehabilitation In Sarcopenia (IRIS)
Status: COMPLETED
Conditions: Sarcopenia
Interventions: DIETARY_SUPPLEMENT: Experimental product|DIETARY_SUPPLEMENT: Isocaloric placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Hydroxychloroquine in the Treatment of Sudden Sensorineural Hearing Loss
Status: NOT_YET_RECRUITING
Conditions: Sudden Hearing Loss
Interventions: DRUG: Hydroxychloroquine|DRUG: Steroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Eye Tracking Sensor to Detect Cannabis Impairment
Status: TERMINATED
Conditions: Cannabis Intoxication
Interventions: DEVICE: Virtual Reality Eye Tracking after smoking Cannabis - HTC Vive Pro-Eye|DRUG: Cannabis cigarette - 4.0% THC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Thalidomide in Treating Patients With Relapsed Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: B-cell Chronic Lymphocytic Leukemia|Refractory Chronic Lymphocytic Leukemia
Interventions: DRUG: thalidomide|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate Efficacy and Safety of a Water-soluble Head Lice Product.
Status: COMPLETED
Conditions: Head Lice|Pediculosis Capitis
Interventions: DEVICE: X92001666|OTHER: RID shampoo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metformin for the Prevention of CRA Recurrence
Status: UNKNOWN
Conditions: Colorectal Adenoma|Metformin|Chemoprevention
Interventions: DRUG: low-dose metformin|DRUG: high-dose metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Long Term Safety Study of (VIT45) Extension Study: Treatment of Anemia in Non-Dialysis Dependent Chronic Kidney Disease
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Ferric Carboxymaltose (FCM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Innovative Multimodal Imaging Biomarkers to Predict Anatomical Outcome in Naive Patients With wAMD Treated With Brolucizumab.
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: Brolucizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Diagnostic Yield of Radial EBUS Guided Biopsies When Using a Thick (1.7mm) Vs. Thin (1.4 mm) USS Probe.
Status: UNKNOWN
Conditions: Pulmonary Parenchymal Lesions
Interventions: PROCEDURE: Radial EBUS biopsy|DEVICE: Types of Radial Ultrasound probes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Cases With Traumatic and Non Traumatic Brain Damage Treated in the Intensive Care
Status: COMPLETED
Conditions: Brain Injuries
Interventions: OTHER: type of the brain injury|OTHER: type of the brain injury|OTHER: type of the brain injury|OTHER: type of the brain injury|OTHER: type of the brain injury|OTHER: type of the brain injury
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Differences in Radial Artery Occlusion From Two Different Compressive Methods Used in Patients in Order to Achieve Homeostasis After Transradial Catheterization and Their Repercussion in Artery Functionality and Hand Mobility
Status: COMPLETED
Conditions: Transradial Catheterization
Interventions: OTHER: Terumo|OTHER: Tensoplast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Vitamin D Supplementation on Muscle Mass and Function
Status: COMPLETED
Conditions: Obesity|Insulin Resistance|Inflammation
Interventions: DIETARY_SUPPLEMENT: Vitamin D|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: An Individualized Physical Activity Program in Patients Over 65 Years With Hematologic Malignancies
Status: COMPLETED
Conditions: Aged|Aged, 80 and Over|Leukemia, Myeloid, Acute|Lymphoma, Non-Hodgkin|Exercise|Quality of Life|Fatigue
Interventions: OTHER: Individualized physical activity program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Azacitidine and Entinostat in Treating Patients With Stage I Non-Small Cell Lung Cancer That Has Been Removed By Surgery
Status: TERMINATED
Conditions: Stage IA Non-Small Cell Lung Carcinoma|Stage IB Non-Small Cell Lung Carcinoma
Interventions: DRUG: Azacitidine|DRUG: Entinostat|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Hip Exercises on Pelvic Floor Muscle Strength and Function in Older Women With Urinary Incontinence
Status: RECRUITING
Conditions: Urinary Incontinence|Geriatric Syndrome
Interventions: BEHAVIORAL: Hip Muscle Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Double-Blinded Study for Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of ATI-2173 in Healthy Subjects and Subjects With Chronic Hepatitis B Virus Infection
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: ATI-2173|DRUG: ATI-2173 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Post-market Observational Study With the easyEndoTM Universal Linear Cutting Stapler in Standard Laparoscopic and Robot-assisted Laparoscopic Roux-en-Y Gastric Bypass (RYGB) Surgery
Status: WITHDRAWN
Conditions: Obesity|Roux-en-Y Gastric Bypass
Interventions: DEVICE: easyEndoTM Universal Linear Cutting Stapler and reloads (Ezisurg Medical)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pediatric Pain Optimization After Tonsillectomy
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Tonsillitis|Pain, Procedural
Interventions: DRUG: Fentanyl/Hydromorphone|DRUG: Methadone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Positive Airway Pressure Treatment of Obstructive Sleep-disordered Breathing in Hypertensive Disorders of Pregnancy
Status: COMPLETED
Conditions: Hypertensive Disorder of Pregnancy|Sleep Apnea, Obstructive
Interventions: DEVICE: Positive Airway Pressure|DEVICE: Nasal Dilator Strip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study for Patients With Secondary Progressive Multiple Sclerosis
Status: COMPLETED
Conditions: Secondary Progressive Multiple Sclerosis
Interventions: DRUG: dirucotide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypothalamic-Pituitary-Adrenal (HPA) Axis Study in Adult and Adolescent Subjects With Perennial Allergic Rhinitis (PAR)
Status: COMPLETED
Conditions: Perennial Allergic Rhinitis
Interventions: DRUG: Placebo Nasal Aerosol|DRUG: Prednisone capsules|DRUG: Placebo Prednisone Capsules|DRUG: Beclomethasone dipropionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of a Treated, Devitalized and Sterile Meniscus Segment (MENISC-T) in the Treatment of Scaphotrapeziotrapezoid Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis Hand
Interventions: BIOLOGICAL: MENISC-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Complications Associated With Multiple Central Venous Accesses in the Internal Jugular Vein
Status: NOT_YET_RECRUITING
Conditions: Central Venous Catheters|Catheter Complications|Catheter Related Complication
Interventions: PROCEDURE: Multiple central venous lines in two sites separately|PROCEDURE: Multiple central venous lines in one site (internal jugular vein)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib Tosylate With or Without Everolimus in Treating Patients With Advanced, Radioactive Iodine Refractory Hurthle Cell Thyroid Cancer
Status: UNKNOWN
Conditions: Refractory Hurthle Cell Thyroid Cancer
Interventions: DRUG: sorafenib|DRUG: everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Sorafenib + Carboplatin and Docetaxel in First Line Treatment of Stage IIIB/IV NSCLC
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Sorafenib + Docetaxel/Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Two Nursing Programs on the Surgery-related Pressure Injury
Status: COMPLETED
Conditions: Pressure Injury|Surgery
Interventions: COMBINATION_PRODUCT: full bed silicone mattress plus other measures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of BBI608 and BBI503 Administered in Combination to Adult Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Cancer|Advanced Solid Tumors
Interventions: DRUG: BBI608|DRUG: BBI503
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digital Multimodal Rehabilitation for People With Post-acute COVID-19 Syndrome.
Status: RECRUITING
Conditions: Post-COVID Syndrome
Interventions: BEHAVIORAL: RehabCovid_Telematic|BEHAVIORAL: RehabCovid_ImmersiveVR|BEHAVIORAL: Control_Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Pharmacokinetics, Safety and Tolerability of Aztreonam-Avibactam in Healthy Chinese Participants.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Aztreonam-Avibactam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bevacizumab or Pemetrexed Disodium Alone or In Combination After Induction Therapy in Treating Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|BIOLOGICAL: Bevacizumab|DRUG: Pemetrexed Disodium Heptahydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ultrasound-Guided Hydrodissection in Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Musculoskeletal Diseases|Median Nerve Disease|Carpal Tunnel Syndrome|Ultrasound-Guided Injection
Interventions: PROCEDURE: Ultrasound-guided Hydrodissection (HD) with 5 cc 5% Dextrose|PROCEDURE: Ultrasound-guided Hydrodissection (HD) with 5 cc Normal Saline|PROCEDURE: Ultrasound-guided Hydrodissection (HD) with 10 cc 5% Dextrose|PROCEDURE: Ultrasound-guided Hydrodissection (HD) with 10 cc Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Fluconazole, Clarithromycin, and Rifabutin on the Pharmacokinetics of Sulfamethoxazole-Trimethoprim and Dapsone and Their Hydroxylamine Metabolites
Status: COMPLETED
Conditions: Bacterial Infections|Mycoses|HIV Infections
Interventions: DRUG: Clarithromycin|DRUG: Rifabutin|DRUG: Sulfamethoxazole-Trimethoprim|DRUG: Dapsone|DRUG: Fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare How the Body Changes the Blood Level of Darifenacin Tablet Form vs. the Modified Release Liquid Form in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Darifenacin (DAR328)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastrointestinal Biomarkers in Tissue and Biological Fluid Samples From Colorectal Cancer Patients
Status: RECRUITING
Conditions: Colorectal Cancer|Esophageal Cancer|Gastric Cancer|Pancreatic Cancer|Precancerous Condition
Interventions: GENETIC: protein analysis|GENETIC: proteomic profiling|OTHER: biologic sample preservation procedure|OTHER: laboratory biomarker analysis|OTHER: medical chart review|PROCEDURE: diagnostic colonoscopy|PROCEDURE: diagnostic endoscopic procedure|PROCEDURE: diagnostic endoscopic surgery|PROCEDURE: diagnostic surgical procedure|PROCEDURE: endoscopic surgery|PROCEDURE: screening colonoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 1b Study Investigating Safety & Immunogenicity of TDV Given Intradermally by Needle or Needle-Free PharmaJet Injector
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: TDV|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Functional Electrical Stimulation (FES) Cycling for Children With Spinal Cord Injuries (SCI)
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: DEVICE: FES Cycle|DEVICE: ES therapy|DEVICE: Passive (Motor Assist) Cycle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EpiCare@Home Validation Study for Focal Onset Seizures
Status: RECRUITING
Conditions: Epilepsy|Seizures|Seizures, Focal|Seizure, Refractory
Interventions: DEVICE: EpiCare@Home, wearable multimodal seizure monitoring system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study on the Safety and Effectiveness of Adefovir Dipivoxil in Combination With Anti-HIV Therapy (HAART) in HIV-Positive Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Adefovir dipivoxil
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: PCV10 Reactogenicity and Immunogenicity Study - Malindi
Status: UNKNOWN
Conditions: Pneumococcal Pneumonia
Interventions: BIOLOGICAL: PCV10 and DTaP|BIOLOGICAL: PCV10 and DTaP|BIOLOGICAL: hepatitis A vaccine, DTaP, PCV10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Devel. and Eval. of an Active Surveillance Decision Aid for Men With Low or Intermediate Grade Prostate Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of Prostate
Interventions: BEHAVIORAL: Dashboard
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment of Systemically Administered Torisel Delivery to Brain Tumors by Intratumoral Microdialysis
Status: WITHDRAWN
Conditions: Brain Neoplasms
Interventions: DRUG: Temsirolimus (Torisel)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Correlation Between Pharmacokinetic and Pharmacodynamic Parameters of CellCept (Mycophenolate Mofetil).
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: mycophenolate mofetil|DRUG: antibody induction|DRUG: Cyclosporine|DRUG: corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Triazolam Trial In Healthy Subjects To Compare Bioavailability Between Formulations Of Triazolam To Determine Their Bioequivalence In Terms Of Rate And Magnitude Of Absorption
Status: WITHDRAWN
Conditions: Healthy Volunteers
Interventions: DRUG: Triazolam|DRUG: Triazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Phase 1, Open-Label, Parallel Group Study to Evaluate the Pharmacokinetics and Safety of DARE-HRT1 in Healthy PostMenopausal Women
Status: COMPLETED
Conditions: Vulvovaginal Atrophy|Vasomotor Symptoms
Interventions: DEVICE: IVR Dose 1|DEVICE: IVR Dose 2|DRUG: Oral Reference
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Chloral Hydrate on Induction, Maintenance, and Recovery From Sevoflurane Anesthesia in Day-case Pediatric Surgery
Status: COMPLETED
Conditions: Pediatric
Interventions: DRUG: chloral hydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose:
Clinical trial: Evaluation of Intra-articular Injection of Autologous Protein Solution ("APS(TM)") for the Treatment of Osteoarthritis (OA)
Status: COMPLETED
Conditions: Gonarthrosis|Knee Osteoarthritis|Osteoarthritis
Interventions: DEVICE: Autologous Protein Solution "APS(TM)"
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effects of Probiotic Yoghurt on Reducing the Levels of Aflatoxin B1 Toxin Among the School Children in Eastern Kenya
Status: UNKNOWN
Conditions: Aflatoxicosis
Interventions: DIETARY_SUPPLEMENT: probiotic yoghurt
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Microinvasive Glaucoma Surgery -The Lowering Effect of Intraocular Pressure on Glaucoma Patients With High Frequency Deep Sclerotomy
Status: RECRUITING
Conditions: Primary Open Angle Glaucoma|Intraocular Pressure|Glaucoma Surgery
Interventions: PROCEDURE: High frequency deep sclerotomy (HFDS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Chemoradiotherapy With CApecitabine and Temozolomide in MGMT Silenced, MSS, Locally Advanced RecTal Cancer
Status: RECRUITING
Conditions: Rectal Cancer
Interventions: RADIATION: External-beam radiation|DRUG: Capecitabine|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Versus Conventional Cessation of Hydrocortisone in Septic Shock
Status: RECRUITING
Conditions: Septic Shock|Adverse Event|Hydrocortisone|Hyperglycemia|Hypernatremia|Muscle Weakness|Superimposed Infection
Interventions: DRUG: normal saline solution|DRUG: Hydrocortisone and normal saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrating Hypertension and Cardiovascular Diseases Care Into Existing HIV Services Package in Botswana (InterCARE)
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections|Hypertension
Interventions: OTHER: InterCARE package
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Radiofrequency Thoracic Sympathectomy for Chronic Postmastectomy Pain; Randomized Placebo Controlled Study
Status: COMPLETED
Conditions: Post-Mastectomy Chronic Pain Syndrome
Interventions: PROCEDURE: radiofrequency thoracic sympathectomy|DRUG: pregabalin ,tramadol,and tricyclic antidepressants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Individualized Neoantigen Peptides in the Treatment of EGFR Mutant Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Individualized neoantigen peptides vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Burnout on Patient-Centered Care: A Comparative Effectiveness Trial in Mental Health
Status: COMPLETED
Conditions: Burnout|Quality of Care
Interventions: BEHAVIORAL: Motivational Interviewing (MI)|BEHAVIORAL: Burnout Reduction: Enhanced Awareness, Tools, Handouts, and Education (BREATHE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety and Pharmacokinetics of Ataluren in Participants From ≥6 Months to <2 Years of Age With Nonsense Mutation Duchenne Muscular Dystrophy (nmDMD)
Status: COMPLETED
Conditions: Nonsene Mutation Duchenne Muscular Dystrophy
Interventions: DRUG: Ataluren
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Specific Immunotherapy With Recombinant Birch Pollen Allergen rBet v1-FV
Status: COMPLETED
Conditions: Birch Pollen Allergy
Interventions: BIOLOGICAL: Recombinant birch pollen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of Nifekalant Hydrochloride (NIF) Injection.
Status: UNKNOWN
Conditions: Ventricular Tachycardia|Ventricular Fibrillation
Interventions: DRUG: Nifekalant hydrochloride|DRUG: Amiodarone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brinzolamide/Brimonidine Combination vs Brimonidine 0.2% in the Prevention of IOP Rise After Nd-YAG Laser Capsulotomy
Status: COMPLETED
Conditions: Posterior Capsule Opacification|Ocular Hypertension
Interventions: DRUG: Brinzolamide/Brimonidine FC|DRUG: Brimonidine 0.2%|DRUG: Artificial tears
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Distal Pancreatectomy, Minimally Invasive or Open, for Malignancy (DIPLOMA)
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma
Interventions: PROCEDURE: minimally invasive distal pancreatectomy|PROCEDURE: open distal pancreatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Electro Flo 5000 and Vest Therapy
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DEVICE: Electro Flo 5000|DEVICE: Incourage Vest System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Milk for Diabetes Prevention
Status: NOT_YET_RECRUITING
Conditions: Lactose Intolerance|Lactose Intolerant|Lactase Persistence|Pre-Diabetes|Diabetes Mellitus, Type 2
Interventions: DIETARY_SUPPLEMENT: Lactose-Containing Milk|DIETARY_SUPPLEMENT: Lactose-Free Milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating the Safety, in Terms of HBV Virological Control at 96 Weeks, of 2 Antiviral Treatment Relief Strategies, in Patients Co-infected With the HIV-1 and HBV Viruses
Status: NOT_YET_RECRUITING
Conditions: HIV Infections|HBV Coinfection
Interventions: DRUG: TDF - 245mg or TAF -25mg associated to 3TC - 300mg or FTC - 200mg and a NNRTI or PI/r or INSTI|DRUG: Dual therapy with 3TC in combination with DTG or ritonavir-boosted Darunavir (rDVR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a New Delivery System for Beta-hydroxy-beta-methylbutyrate
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: CaHMB|DIETARY_SUPPLEMENT: HMB Free Acid Gel|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Placebo Gel Dosage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Non-invasive Auricular Simulation for Exam Anxiety and Depression in University Students
Status: RECRUITING
Conditions: Anxiety|Stress|Insomnia
Interventions: OTHER: Non-invasive auricular stimulation|OTHER: Sham auricular stimulation (SAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparing Between XP Endo Finisher and Conventional Irrigation Method On Post-Operative Flare Ups In Necrotic Teeth
Status: UNKNOWN
Conditions: Dental Pulp Necroses
Interventions: PROCEDURE: XP Endo Finsher as final step of the irrigation protocol|PROCEDURE: Conventional needle irrigation only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Cancer Vaccine (CG8123) Given With and Without Cyclophosphamide for Advanced Stage Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Lung Cancer|Carcinoma, Non-Small-Cell Lung
Interventions: BIOLOGICAL: CG8123|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Renal deNervation on Arterial Stiffness and Haemodynamics in Patients With UncontRolled hypErtension (ENSURE)
Status: UNKNOWN
Conditions: Resistant Hypertensive Patients
Interventions: PROCEDURE: Renal denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)
Status: RECRUITING
Conditions: Hiv
Interventions: OTHER: HIV D+/R+|OTHER: HIV D-/R+
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PTSD Prevention Study Examining the Efficacy of Sertraline in Burn Victims
Status: TERMINATED
Conditions: Post-traumatic Stress Disorder
Interventions: DRUG: Sertraline|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dietary Nitrates and Vascular Function in Patients With Peripheral Artery Disease
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: DIETARY_SUPPLEMENT: Sodium Nitrate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PRE-I-SPY Phase I/Ib Oncology Platform Program
Status: RECRUITING
Conditions: HER2-positive Breast Cancer|Metastatic Cancer|Metastatic Breast Cancer|Metastatic|HER2-positive Metastatic Breast Cancer|HER2 Mutation-Related Tumors|HER-2 Protein Overexpression|HER2-negative Breast Cancer|Triple Negative Breast Cancer|HR Positive|Hormone Receptor-positive Breast Cancer|Estrogen Receptor Positive Tumor|Progesterone Receptor-positive Breast Cancer|Hormone Receptor Negative Breast Carcinoma|Solid Tumor|Solid Tumor, Adult|Solid Carcinoma|HER2 Low Breast Cancer|HER2 Low Breast Carcinoma|ER Positive Breast Cancer|PR-positive Breast Cancer
Interventions: DRUG: ALX148|DRUG: Fam-Trastuzumab Deruxtecan-Nxki|DRUG: Zanidatamab|DRUG: Tucatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Asthma and Quantifying Delivery Of Radio Labeled Aerosol
Status: COMPLETED
Conditions: Asthma
Interventions: OTHER: Noninvasive ventilation|DEVICE: Jet nebulizer|DEVICE: The vibrating mesh nebulizer (VMN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Effect of a Plant Extract on Fatigue
Status: COMPLETED
Conditions: Mental Energy|Physical Performance
Interventions: OTHER: Flavored beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of PS-341 Given to Patients With Multiple Myeloma Who Experienced Progressive Disease After Receiving Dexamethasone in M34101-039
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of and Immune Response to a Dengue Virus Vaccine (rDEN3/4delta30[ME]) in Healthy Adults
Status: COMPLETED
Conditions: Dengue
Interventions: BIOLOGICAL: rDEN3/4delta30(ME)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Two Non-pharmacological Methods on Pain and Anxiety Experienced During Intrauterine Device Application.
Status: RECRUITING
Conditions: Intrauterine Devices
Interventions: OTHER: Emotional freedom technique group|OTHER: Music group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Astaxanthin Supplementation on Plasma Malondialdehyde Levels and NIHSS of Stroke Patients
Status: COMPLETED
Conditions: Cerebral Stroke|Malondialdehyde|Oxidative Stress
Interventions: DRUG: Astaxanthine|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Biweekly Gemcitabine, Paclitaxel, and Avastin in Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Paclitaxel|DRUG: Gemcitabine|DRUG: Avastin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Performance of Cognitive Behavioral Therapy for Insomnia With an Integrative Mobile Platform
Status: UNKNOWN
Conditions: Primary Insomnia|Depressive Disorders With Insomnia
Interventions: BEHAVIORAL: App modules|BEHAVIORAL: Traditional CBT-I
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Abnormal Regulation, Estimation and Cognitive Impacts of Physical Efforts as an Endophenotype of Anorexia Nervosa
Status: UNKNOWN
Conditions: Anorexia Nervosa
Interventions: OTHER: Clinical and biological examination, Saliva (or blood) test Glycemia, thermal test, cognitive and bike tests, questionnaires|OTHER: Clinical examination, Glycemia, saliva (or blood) test, thermal test, cognitive and bike tests, questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Feasibility Study to Assess Outcomes of Immediately Inserted and Restored Dental Implants Using pH-modified Tetranite
Status: RECRUITING
Conditions: Adhesive Dental
Interventions: DEVICE: Tetranite Implant Stabilization Material
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Nitric Oxide Bioavailability on Vascular Health in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Tetrahydrobiopterin (BH4)|DIETARY_SUPPLEMENT: Antioxidant Cocktail
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRO With Luxerm® in the Field Treatment of Thin and Non-hyperkeratotic Non-pigmented AK
Status: COMPLETED
Conditions: Actinic Keratoses
Interventions: DRUG: Methyl Aminolaevulinate 16% Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Blood Flow Restriction Therapy in Achilles Injury
Status: RECRUITING
Conditions: Achilles Injuries Tendon
Interventions: OTHER: Standard of Care Physical Therapy|OTHER: Blood flow restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a 6-week Specific Rehabilitation Program on Walking Capacity in Patients With Lumbar Spinal Stenosis
Status: RECRUITING
Conditions: Spinal Stenosis
Interventions: OTHER: Exercises and education|OTHER: Education alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Devices as an Adjunct to Usual Care for Patients With Sickle Cell Disease Experiencing Vaso-Occlusive Crises
Status: NOT_YET_RECRUITING
Conditions: Sickle Cell Disease|Vaso-occlusive Pain Episode in Sickle Cell Disease|Acute Pain
Interventions: DEVICE: Virtual Reality Headset and Hand-Held Controllers|OTHER: Blindfolding and Noise Cancelling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploration of the Neuroplasticity of Endogenous Analgesia in Health and Chronic Pain
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: active repeated transcranial magnetic stimulation|DEVICE: 'sham' repeated transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Single-lumen 5Fr and Triple-lumen 6Fr PICCs Are Accurate for Hemodynamic Measurement by Transpulmonary Thermodilution.
Status: COMPLETED
Conditions: Peripherally Inserted Central Catheters|Centrally Inserted Central Catheter|Transpulmonary Thermodilution|Hemodynamic Monitoring
Interventions: DIAGNOSTIC_TEST: transpolmonary thermodilution
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Postpartum Low-Dose Aspirin and Preeclampsia
Status: RECRUITING
Conditions: Preeclampsia Postpartum
Interventions: DRUG: Aspirin tablet|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Technological Platforms and Telerehabilitation in Heart Surgery
Status: COMPLETED
Conditions: Cardiovascular Diseases|Cardiac Surgery
Interventions: DEVICE: Telerehabilitation Monitors|PROCEDURE: Physical Therapy|BEHAVIORAL: Nutritional Counseling|OTHER: Depression Screening|DRUG: Treatment of Comorbidities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Long-Term Safety Extension of Studies ABE4869g and ABE4955g in Participants With Mild to Moderate Alzheimer's Disease Treated With Crenezumab
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Crenezumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positive Action for Today's Health
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Police Patrolled Walking plus Social Marketing|BEHAVIORAL: Police Patrolled Walking Program Only|BEHAVIORAL: General Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Role of the Endogenous Opioid System Underlying Modulation of Experimental Pain
Status: WITHDRAWN
Conditions: Temporomandibular Disorder|Facial Pain
Interventions: DRUG: Naltrexone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE