pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of JNJ-64251330 in Participants With Familial Adenomatous Polyposis
Status: COMPLETED
Conditions: Adenomatous Polyposis Coli
Interventions: DRUG: JNJ-64251330
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cash Benefits and Reproductive/Perinatal Health
Status: ACTIVE_NOT_RECRUITING
Conditions: Maternal Care Patterns|Pregnancy Related|Miscarriage
Interventions: OTHER: Cash Benefit|OTHER: No Cash Benefit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Immediate Preoperative Instillation (IPOI) of Mitomycin C Compared to Early Postoperative Instillation (IPOP) in Non-muscle Invasive Bladder Cancer
Status: UNKNOWN
Conditions: Non Muscle-invasive Bladder Cancer
Interventions: PROCEDURE: IPOI (pre-operative)|PROCEDURE: IPOP (post-operative)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First Add-on vs. Mono-therapy Study of Topiramate in Neuro-Surgical Patients
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Topiramate add-on therapy|DRUG: Topiramate monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Pharmacokinetics, Safety, and Tolerability of Delamanid in Combination With Optimized Multidrug Background Regimen (OBR) for Multidrug-Resistant Tuberculosis (MDR-TB) in HIV-Infected and HIV-Uninfected Children With MDR-TB
Status: RECRUITING
Conditions: Tuberculosis|HIV Infections
Interventions: DRUG: Delamanid|DRUG: Optimized multidrug background regimen (OBR) for children with MDR-TB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Timing of Surgery in Nonmetastatic Osteosarcoma of the Pelvis and Sacrum
Status: RECRUITING
Conditions: Osteosarcoma of Pelvis
Interventions: DRUG: Doxorubicin|DRUG: Cisplatin|DRUG: Methotrexate|DRUG: Ifosfamide|PROCEDURE: definitive surgery|OTHER: pre surgical chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Low Molecular Weight Heparins
Status: RECRUITING
Conditions: Anticoagulant|Venous Thromboembolism|Prophylaxis|Treatment
Interventions: DRUG: Dalteparin Prefilled Syringe|DRUG: Tinzaparin profiled syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Laryngeal Mask Airway in Pediatric Adenotonsillectomy
Status: COMPLETED
Conditions: Laryngeal Mask Airway|Tonsillectomy
Interventions: DEVICE: Endotracheal Tube|DEVICE: Laryngeal mask airway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Hepatocellular Carcinoma With Radiofrequency Ablation (RFA) Associated With Postoperative TACE
Status: UNKNOWN
Conditions: Cancer of Liver
Interventions: PROCEDURE: radiofrequency ablation associated with TACE|PROCEDURE: radiofrequency ablation only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Gender and Culturally Specific Approach to Reduce NAFLD in Mexican-American Men
Status: RECRUITING
Conditions: NAFLD
Interventions: BEHAVIORAL: NAFLD-specific weight loss intervention|OTHER: Wait-list control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Acupuncture to Treat Bell's Palsy According to Different Stages
Status: COMPLETED
Conditions: Bell's Palsy
Interventions: OTHER: acupuncture|OTHER: acupuncture and moxibustion|OTHER: electroacupuncture|OTHER: acupuncture along yangming tendons|OTHER: acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Gabapentin on Chronic Irritability in Neurologically Impaired Children
Status: TERMINATED
Conditions: Neurologically Impaired|Irritable Mood|Signs and Symptoms, Digestive|Sleeplessness|Chronic Pain
Interventions: DRUG: Gabapentin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sacubitril/Valsartan vs Lifestyle in Hypertrophic Cardiomyopathy
Status: COMPLETED
Conditions: Hypertrophic Cardiomyopathy
Interventions: BEHAVIORAL: Lifestyle|DRUG: Sacubitril/Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Abuse Among Patients With Rheumatic Diseases
Status: RECRUITING
Conditions: Rheumatic Diseases|Abuse Neglect|Abuse
Interventions: OTHER: Rheumatic diseases Mistreatment Scale (RDMS)|OTHER: Health Assessment Questionnaire (HAQ)|OTHER: Depression, Anxiety and Stress Scale (DASS-21)|OTHER: Brief Resilient Coping Scale|OTHER: WHOQOL-BREF|OTHER: Routine assessment of patient index data 3 (RAPID-3)|OTHER: Big Five Inventory|OTHER: Family APGAR Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Long-term Safety Study of Open-label Pramipexole ER in Patients With Advanced PD
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Pramipexole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-escalating Phase I Trial With GEM333 in Patients With Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|Relapsed AML|Refractory AML
Interventions: DRUG: GEM333
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RECOVER-ENERGIZE Platform Protocol_Appendix A (Exercise Intolerance)
Status: RECRUITING
Conditions: Long COVID|Long Covid19|Long Covid-19
Interventions: BEHAVIORAL: Personalized Cardiopulmonary Rehabilitation|OTHER: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Precision Hypertension Care Study
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Zestril®|DRUG: Atacand®|DRUG: Norvasc®|DRUG: Hydrochlorthiazide®|DRUG: Treatment X|DRUG: Treatment Y|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating SKI-606 (Bosutinib) In Advanced Malignant Solid Tumors
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: bosutinib|DRUG: bosutinib|DRUG: bosutinib|DRUG: bosutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Safety Profile of AZD4721 After Single Doses at Different Dose Levels
Status: COMPLETED
Conditions: Safety,Plasma AUC and Cmax, Plasma AUC 0-t, t1/2λz, and Tmax
Interventions: DRUG: AZD4721 Solution|DRUG: AZD4721 Placebo|DRUG: AZD4721 Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Investigation of Dexamethasone With Different Doses in the Management of Immune Thrombocytopenia (ITP)
Status: COMPLETED
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Dexamethasone|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Evaluation of Different Sequential Immunization Strategies by Sabin IPV and bOPV in Chinese Infants
Status: COMPLETED
Conditions: Polio
Interventions: BIOLOGICAL: Sabin IPV+ bOPV+ bOPV|BIOLOGICAL: Sabin IPV + Sabin IPV + bOPV|BIOLOGICAL: Sabin IPV + Sabin IPV + Sabin IPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of HMOs on the Faecal Microbiota and on Host Metabolism in Obese Children
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: HMO|DIETARY_SUPPLEMENT: Dextropur
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of ACE-86225106 to Treat Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor, Adult|BRCA1 Mutation|BRCA2 Mutation|Ovarian Cancer|Breast Cancer|Prostate Cancer
Interventions: DRUG: ACE-86225106 tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AAA-SHAPE Pivotal Trial: Abdominal Aortic Aneurysm Sac Healing and Prevention of Expansion
Status: RECRUITING
Conditions: Aortic Aneurysm, Abdominal
Interventions: DEVICE: IMPEDE-FX RapidFill Implants|PROCEDURE: EndoVascular Aneurysm Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Letrozole Improve the Outcomes and/or Reduce the Cost of IVF-ET Cycles?
Status: WITHDRAWN
Conditions: Infertility
Interventions: DRUG: Letrozole|DRUG: Std IVF Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketamine-enhanced Prolonged Exposure Therapy in PTSD
Status: RECRUITING
Conditions: PTSD
Interventions: DRUG: Ketamine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Characterize the Pharmacokinetics, Pharmacodynamics, and Safety of Anifrolumab in Adult Type I Interferon Test High Systemic Lupus Erythematosus Subject With Active Skin Manifestations
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Anifrolumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adductor Canal Block for Total Knee Arthroplasty
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Knee|Pain, Postoperative
Interventions: PROCEDURE: Adductor Canal Block|DRUG: Adductor Canal Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study in Healthy Men to Test Whether Esomeprazole Influences the Amount of BI 3000202 in the Blood
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 300202|DRUG: esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Haemodynamic Effects of Dobutamine in Patients With Wild-type Transthyretin Amyloid Cardiomyopathy (ATTRwt)
Status: RECRUITING
Conditions: ATTR Amyloidosis Wild Type
Interventions: DRUG: Dobutrex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Butorphanol Tartrate Injection for the Patients With Mechanical Ventilation
Status: UNKNOWN
Conditions: Analgesia|Hospital-acquired Infections
Interventions: DRUG: Butorphanol Tartrate Injection|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hepatocellular Carcinoma - Advanced Stage - Sorafenib Trial in Taiwanese Patients
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Sorafenib (Nexavar, BAY43-9006) Sorafenib (Nexavar, BAY43-9006) + Nerison Fatty Ointment Sorafenib (Nexavar, BAY43-9006)+Neribas Fatty Ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduction in Infarct Size by Remote Per-postconditioning in Patients With ST-elevation Myocardial Infarction
Status: COMPLETED
Conditions: Coronary Artery Disease|Myocardial Infarction
Interventions: PROCEDURE: Primary Percutaneous Coronary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aromatherapy and Yogatherapy for Hot Flashes
Status: COMPLETED
Conditions: Menopause|Hot Flashes|Hot Flushes
Interventions: OTHER: Olfactory aromatherapy|OTHER: Yogatherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Proximal Interphalangeal Joint Injuries. Clinical Efficiency of Syndactyly Treatment and Digital Compression
Status: TERMINATED
Conditions: Finger Injuries
Interventions: DEVICE: Syndactyly without compression|DEVICE: Syndactyly with compression|DEVICE: Rigid splint without compression|DEVICE: Rigid splint with compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Mechanisms of Low-intensity Focused Ultrasound on Negative Symptoms in Patients With Schizophrenia
Status: UNKNOWN
Conditions: Negative Symptoms of Schizophrenia
Interventions: DEVICE: Low-intensity Focused Ultrasound(LIFUS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Syndromes|Keratoconjunctivitis Sicca
Interventions: DRUG: KPI-121|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ursofalk Tablets (500 mg) Versus Ursofalk Capsules (250 mg) in the Treatment of Primary Biliary Cirrhosis
Status: COMPLETED
Conditions: Primary Biliary Cirrhosis
Interventions: DRUG: UDCA (Ursodeoxycholic acid)|DRUG: UDCA (Ursodeoxycholic acid)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study of XL765 (SAR245409) or XL147 (SAR245408) in Subjects With Recurrent Glioblastoma Who Are Candidates for Surgical Resection
Status: COMPLETED
Conditions: Glioblastoma|Astrocytoma, Grade IV
Interventions: DRUG: XL765 (SAR245409)|DRUG: XL147 (SAR245408)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of IVF Hormonal Therapy on Endometrial Receptivity and Endometrial Senescent Cell Pathological Accumulation
Status: RECRUITING
Conditions: Endometrial Receptivity
Interventions: PROCEDURE: Controlled Ovarian Stimulation + Luteal Phase Support|PROCEDURE: Hormonal Replacement Therapy programmed artificial cycle|PROCEDURE: Natural Cycle (NC)|PROCEDURE: Endometrial receptivity reference group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Setmelanotide for the Treatment of Leptin Receptor (LEPR) Deficiency Obesity
Status: COMPLETED
Conditions: Leptin Receptor Deficiency Obesity
Interventions: DRUG: Setmelanotide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of Oral Netupitant and Palonosetron for the Prevention of Nausea and Vomiting
Status: COMPLETED
Conditions: Chemotherapy-Induced Nausea and Vomiting
Interventions: DRUG: Netupitant and Palonosetron|DRUG: Palonosetron|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Dalfampridine (4-AP) on Genioglossus Muscle Activity in Healthy Adults
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DRUG: Placebo|DRUG: Dalfampridine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intensive Cholecalciferol Monitoring and Supplementation on Serum vitD Levels in Pediatric Patients With CF
Status: UNKNOWN
Conditions: Vitamin D Deficiency|Cystic Fibrosis|Bone Density, Low|Inflammation Chronic|Cystic Fibrosis in Children|Cystic Fibrosis Pulmonary Exacerbation
Interventions: DRUG: Cholecalciferol Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Light Irradiation and Outcome for Neuropathic Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Complex Regional Pain Syndrome
Interventions: OTHER: Linearly Polarized Near-Infrared light Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Hydrogen Peroxide Gel on Periodontitis With Diabetes
Status: WITHDRAWN
Conditions: Periodontitis|Diabetes Mellitus
Interventions: COMBINATION_PRODUCT: PerioProtect ™= plastic tray +1.7% hydrogen peroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Airway Muscle Training for Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Respiratory muscle strength training|DEVICE: Sham respiratory muscle strength training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Predictive Value of Reduced Keratinized Mucosa on the Secondary Prevention of Peri-implant Mucositis and Periimplantitis in Patients Attending Regular Supportive Peri-implant Care. A Longitudinal Analysis
Status: COMPLETED
Conditions: Peri-Implantitis|Peri-implant Mucositis|Lack of Keratinized Gingiva
Interventions: DIAGNOSTIC_TEST: Measurement of implant parameters
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: BRAVE-DREAMS (BRAin VEnous DRainage Exploited Against Multiple Sclerosis)
Status: COMPLETED
Conditions: Multiple Sclerosis|Venous Insufficiency
Interventions: PROCEDURE: Venous PTA|OTHER: Catheter Venography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Controlling Myopia Progression With Soft Contact Lenses
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Test Soft Contact Lens B|DEVICE: Test Soft Contact Lens C|DEVICE: Active Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Similarity in Pharmacokinetics and Safety of IBI310 and Ipilimumab（YERVOY）in Adult Healthy Chinese Male Volunteers
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Subjects
Interventions: DRUG: Ipilimumab|DRUG: IBI310
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Low-Carbohydrate Dietary Pattern on Glycemic Outcomes Trial
Status: COMPLETED
Conditions: Diabetes|PreDiabetes|Metabolic Disease|Hyperglycemia|Diet Modification|Glucose Intolerance|Glucose Metabolism Disorders (Including Diabetes Mellitus)|Endocrine System Diseases
Interventions: BEHAVIORAL: Low-Carbohydrate Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cut-off Values of 6-min Walk Test and Sit-to-stand Test for Determining Symptom Burden and Functional Impairment in Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: OTHER: Evaluation of functional impairment|OTHER: Evaluation of pulmonary function|OTHER: Evaluation of quality of life|OTHER: Evaluation of physical activity level
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Biodegradable Stenting Anastomoses Versus Double-layer Hand Sutures for Reconstruction in Intestinal Anastomosis
Status: UNKNOWN
Conditions: Colonic Neoplasms|Diverticulosis, Colonic|Crohn Disease
Interventions: PROCEDURE: Biodegradable Stenting Anastomoses|PROCEDURE: Double-layer Hand Sutures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Eprosartan/HCT Versus Enalapril/HCT in Hypertensives With Type II Diabetes
Status: COMPLETED
Conditions: Hypertension|Type 2 Diabetes
Interventions: DRUG: eprosartan/HCTZ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: n-3 Polyunsaturated Fatty Acids in Obesity
Status: COMPLETED
Conditions: Adipose Tissue Inflammation|Morbid Obesity
Interventions: DRUG: reesterified long-chain n-3 polyunsaturated fatty acids (EPA, DHA)|DRUG: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Multiple Dose Comparison of Tiotropium Inhalation Capsules and Salmeterol Inhalation Aerosol.
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium|DRUG: Salmeterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Role of CT-PET-MRI Image Fusion in Determining Radiation Treatment Volumes of Head-and-Neck Cancer Patients
Status: COMPLETED
Conditions: Head and Neck Neoplasms
Interventions: PROCEDURE: PET-scan, MRI-scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conduction System Pacing With Left Bundle Branch Pacing as Compared to Standard Right Ventricular Pacing
Status: RECRUITING
Conditions: Pacemaker DDD|Heart Block
Interventions: DEVICE: Left bundle branch pacing lead (Select Secure 3830 lead)|DEVICE: Right ventricular active fixation lead
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label Study to Define the Safety, Tolerability and Clinical Activity of Deutetrabenazine (AUstedo) in Adult Study Subjects With DYsTonia
Status: ACTIVE_NOT_RECRUITING
Conditions: Dystonia, Primary
Interventions: DRUG: Deutetrabenazine 6 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HSPPC-96 Vaccine With Temozolomide in Patients With Newly Diagnosed GBM
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: BIOLOGICAL: HSPPC-96|DRUG: Temozolomide|PROCEDURE: Standard Surgical Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Respiratory Variations in the Diameter of the Inferior Vena Cava With Spontaneous Ventilation
Status: COMPLETED
Conditions: Collapsibility of the Inferior Vena Cava
Interventions: PROCEDURE: Ultrasounds with controlled breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetics and Point of Care Testing of Direct Oral Anticoagulants Subjects
Status: UNKNOWN
Conditions: Anticoagulant Therapy
Interventions: DRUG: Apixaban 5 MG Tab|DRUG: Dabigatran 150 MG Tab|DRUG: Edoxaban 60Mg Tab|DRUG: Rivaroxaban 20 MG Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: SA55 Injection: a Potential Therapy for the Prevention and Treatment of COVID-19
Status: RECRUITING
Conditions: COVID-19
Interventions: DRUG: SA55 Injection|OTHER: Placebo for SA55 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effects of Omega-3 Supplementation on Serum HSP27, HSP70, YKL40, BMP-4 Levels in Male Patient With CAD
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: Omega-3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feeding America Intervention Trial for Health--Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: OTHER: Testing and Monitoring of Blood Glucose Levels|OTHER: Primary care coordination|OTHER: Diabetes-appropriate food packages|BEHAVIORAL: Diabetes self-management education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Efficacy and Safety of Empagliflozin Addition to Insulin and Oral Antidiabetic Medication (OAD) Regimen in Poorly Controlled Type 2 Diabetes and Obese Patient
Status: COMPLETED
Conditions: Glucose Metabolism Disorders|Diabetes Mellitus, Type 2|Hypoglycemic Agents|Empagliflozin
Interventions: DRUG: Empagliflozin 10 MG|DRUG: Insulin+Metformin+DPP4 inhibitor (DPP4I)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Adherence to Polypharmacy in Patients With Opioid Substitution Therapy Using Electronics
Status: COMPLETED
Conditions: Substance-Related Disorders
Interventions: DEVICE: electronic medication dispenser (medido)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Linezolid Instead of Ethambutol in Treatment of Drug-susceptible Tuberculosis
Status: UNKNOWN
Conditions: Pulmonary Tuberculosis Without Resistance to Rifampicin
Interventions: DRUG: Linezolid|DRUG: Ethambutol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RANKL-blockade for the Treatment of Erosive Osteoarthritis (OA) of Interphalangeal Finger Joints
Status: COMPLETED
Conditions: Hand Osteoarthritis
Interventions: DRUG: denosumab|DRUG: Placebo|DIETARY_SUPPLEMENT: Calcium/Vit D supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Treatment in High-risk Resectable Pancreatic Cancer With NALIRIFOX
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Irinotecan liposome injection|DRUG: Oxaliplatin|DRUG: 5-FU|DRUG: LV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Choroidal Thickness and Its Correlations With Ocular Parameters in Primary Open-angle Glaucoma
Status: COMPLETED
Conditions: Glaucoma, Open-Angle
Interventions: DRUG: Brimonidine Tartrate|DRUG: Dorzolamide (as Dorzolamide Hydrochloride) 20 Mg/mL and Timolol (as Timolol Maleate) 5 Mg/mL Eye Drops|DRUG: Brinzolamide/Timolol 10 MG/1 ML-5 MG/1 ML Ophthalmic Suspension|DRUG: Travoprost and Timolol|DRUG: Bimatoprost and Timolol|DRUG: Latanoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of a Single Dose of Sirolimus in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects|Pharmacokinetics of Isavuconazole|Pharmacokinetics of Sirolimus
Interventions: DRUG: isavuconazole|DRUG: sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy of Vitamin D on the Clinical Management of Pediatric Patients With Asthma
Status: UNKNOWN
Conditions: Asthma
Interventions: DRUG: GINA treatment fot asthma +vit.D low supplementation dose|DRUG: GINA treatment fot asthma +vit.D high supplementation dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Topical Apraclonidine for the Treatment of Ocular Synkinesis
Status: WITHDRAWN
Conditions: Synkinesis|Facial Nerve Palsy
Interventions: DRUG: Apraclonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hammock Position and Nesting in the Neonatal Intensive Care Unit
Status: RECRUITING
Conditions: Behavior, Nesting|Behavior, Child
Interventions: BEHAVIORAL: Hammock Position|BEHAVIORAL: Nesting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 18F-FCH (Fluorocholine)-PET/MR in Staging of High-Risk Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Fluorocholine (18F-FCH) Injection|RADIATION: PET scan|RADIATION: Whole body MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: PrOton Pulsed reduCed dOse Rate Radiotherapy for Recurrent CNS maligNancies Trial
Status: NOT_YET_RECRUITING
Conditions: Glioma|Glioma, Malignant|Recurrent Glioma
Interventions: RADIATION: PRDR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Explore the Efficacy of Hypofractionated Radiotherapy Followed by AG Regimen Chemotherapy Plus Camrelizumab Immunotherapy as Neoadjuvant Therapy for Locally Advanced Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Camrelizumab+chemotherapy|RADIATION: hypofractionated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Estimate the Relative Bioavailability, Tolerability and Safety of a Single Dose of Belimumab Self-Administered Subcutaneously (SC) by Healthy Subjects
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Belimumab 200 mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Conventional Dose Combination RVD to High-Dose Treatment With ASCT in the Initial Myeloma up to 65 Years
Status: COMPLETED
Conditions: Myeloma
Interventions: DRUG: Lenalidomide, Bortezomib|DRUG: Lenalidomide, Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omentectomy and Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome|Morbid Obesity
Interventions: PROCEDURE: Laparoscopic Roux-en-Y Gastric Bypass|PROCEDURE: Omentectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of MRI Fusion Biopsy Techniques in Men With Elevated PSA and Prior Negative Prostate Biopsy
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: PROCEDURE: MRI UroNav fusion biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Galunisertib (LY2157299) and Durvalumab (MEDI4736) in Participants With Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: Galunisertib|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of NHE and KT on the Hamstring Strength and Sprint Performance in Collegiate Sprinters
Status: COMPLETED
Conditions: Hamstring Injury
Interventions: OTHER: NHE+KT|OTHER: NHE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: TMD-specific Physiotherapy in hEDS Patients Individuals With Hypermobile Ehlers-Danlos Syndrome
Status: RECRUITING
Conditions: Hypermobile Ehlers-Danlos Syndrome
Interventions: PROCEDURE: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ERAS vs Conventional Approach in Peptic Perforation-RCT
Status: COMPLETED
Conditions: Peptic Ulcer Perforation|Perforated Bowel|Post-Op Complication|Emergencies|Perioperative Complication
Interventions: COMBINATION_PRODUCT: Enhanced Recovery after Surgery group|COMBINATION_PRODUCT: Conventional
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Perioperative Evaluation of Terlipressin Infusion During Living Donor Liver Transplantation on Incidence of Acute Kidney
Status: COMPLETED
Conditions: Acute Kidney Injury|Liver Transplantation|Terlipressin|NGAL
Interventions: DRUG: Terlipressin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Design and Clinical Evaluation of a Smartphone-based Low Vision Enhancement System
Status: COMPLETED
Conditions: Low Vision
Interventions: DEVICE: Virtual bioptic magnification with large field of view|DEVICE: Full field magnification with small field of view
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cortical Excitability in Cyclic Vomiting Syndrome
Status: RECRUITING
Conditions: Cyclic Vomiting Syndrome
Interventions: OTHER: TMS Paired-Pulse assessment of cortical excitability|OTHER: Autonomic activity
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neural Stem Cell Treatment for Amyotrophic Lateral Sclerosis (STEMALS)
Status: RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: PROCEDURE: human Neural Stem Cells (hNSC)|PROCEDURE: Saline (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The FOVUS-ER Study: Focused Vascular Ultrasound to Risk Stratify Patients With Chest Pain in the ER
Status: COMPLETED
Conditions: Chest Pain|Acute Coronary Syndrome|Carotid Artery Plaque
Interventions: OTHER: Focused vascular ultrasound of the carotid arteries
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Airborne Pathogen Inactivation Devices Using UVGI Against Respiratory Diseases Affecting Retirement Home Residents
Status: NOT_YET_RECRUITING
Conditions: Respiratory Infections in Old Age
Interventions: DEVICE: UVGI (Ultra-Violet Germicidal Irradiation Device)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of BGC515 Capsules in Subjects With Advanced Solid Tumors
Status: RECRUITING
Conditions: Mesothelioma|Epithelioid Hemangioendothelioma(EHE)|Solid Tumor
Interventions: DRUG: BGC515
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Following Surgery in Treating Patients With Urinary Tract Cancer
Status: COMPLETED
Conditions: Bladder Cancer|Transitional Cell Cancer of the Renal Pelvis and Ureter
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: gemcitabine hydrochloride|DRUG: ifosfamide|DRUG: paclitaxel|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Longitudinal Preschool Wheeze Biomarker Study
Status: RECRUITING
Conditions: Wheezing
Interventions: PROCEDURE: Bronchoscopy, with bronchoalveolar lavage and endobronchial biopsy|DIAGNOSTIC_TEST: Skin prick test|DIAGNOSTIC_TEST: Finger prick blood test|DIAGNOSTIC_TEST: Forced oscillation technique (FOT)|PROCEDURE: Sputum induction|DIAGNOSTIC_TEST: Oropharyngeal swab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of MT-8421 as Monotherapy and in Combination With Nivolumab in Patients With Selected Advanced Solid Cancer Types
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer|Hepatocellular Carcinoma|Melanoma|Renal Cell Carcinoma|Microsatellite Instability High|Mismatch Repair Deficiency|Mesothelioma|Esophageal Squamous Cell Carcinoma|Squamous Cell Carcinoma of Head and Neck|Urothelial Carcinoma|Cervical Cancer
Interventions: DRUG: MT-8421|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of a Sheath Cryoprobe Bronchoscopic Transbronchial Biopsy Technique
Status: COMPLETED
Conditions: Lung Diseases
Interventions: DEVICE: ERBECRYO® 2 Cryosurgical Unit and Accessories - K190651
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Assessment of the Pharmacodynamic Effect on Plasma Folate and Red Blood Cell Folate and Comparison of the Folate Metabolites During the 24 Weeks of Treatment (Yasmin + Metafolin Versus Yasmin + Folic Acid) Followed by a 20 Week Elimination Phase of Folate
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: EE 0.03 mg/DRSP 3 mg/Metafolin + folic acid placebo|DRUG: EE 0.03 mg/DRSP 3 mg (Yasmin) + folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trials of N-acetyl Glucosamine Capsule for IBS-D Treatment
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Starch Placebo|DRUG: N-acetyl-D-glucosamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Preoperative Diclofenac Potassium on Articaine Buccal Infitration Success
Status: COMPLETED
Conditions: Pulpitis - Irreversible|Anesthesia, Local
Interventions: DRUG: Diclofenac Potassium 50mg Tab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nutritional Counseling Based on Self-compassion vs. Diet Approach on Body Dissatisfaction and Disordered Eating
Status: RECRUITING
Conditions: Body Dissatisfaction|Disordered Eating
Interventions: DIETARY_SUPPLEMENT: Diet group|BEHAVIORAL: Self-compassion group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Ilaprazole Based Bismuth-containing Quadruple Regimen for the First-line Treatment of Helicobacter Pylori Infection
Status: COMPLETED
Conditions: Helicobacter Pylori Eradication Antibiotic
Interventions: DRUG: Ilaprazole antisecretory drug of each quadruple therapy the Ilaprazole -based quadruple therapy|DRUG: Esoprazole antisecretory drug of each quadruple therapy Esoprazole-based quadruple therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microstream® Capnography in Endobronchial Ultrasonography Applications Under Sedation
Status: ACTIVE_NOT_RECRUITING
Conditions: Capnography|Endobronchial Ultrasound
Interventions: DEVICE: Capnography Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Conventional VS Enhanced Recovery After Surgery Protocols in Emergency GIT Surgery
Status: UNKNOWN
Conditions: Patient Presented With Acute Abdomen|Patient Undergoing Urgent GIT Surgery
Interventions: COMBINATION_PRODUCT: ERAS protocols|COMBINATION_PRODUCT: Early oral feeding|COMBINATION_PRODUCT: Prophylaxis against DVT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors
Status: COMPLETED
Conditions: Diffuse Intrinsic Pontine Glioma|Brain Tumor, Recurrent|Solid Tumor, Recurrent|Neuroblastoma, Recurrent, Refractory|Ewing Sarcoma, Recurrent, Refractory|Rhabdomyosarcoma, Recurrent, Refractory|Osteosarcoma, Recurrent, Refractory|Rhabdoid Tumor, Recurrent, Refractory
Interventions: DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Real-time CGMS With Intermittently-scanned CGMS in Adolescents and Adults With Type 1 Diabetes Mellitus
Status: RECRUITING
Conditions: Type1 Diabetes Mellitus
Interventions: DEVICE: Medtronic Guardian Connect Sensor 3|DEVICE: Abott Freestyle Libre Sensor|OTHER: Self blood Glucose monitoring by a glucometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Switching From ATRIPLA™ (Efavirenz, Tenofovir, Emtricitabine) to MK-1439A (Doravirine, Tenofovir, Lamivudine) in Virologically-Suppressed Participants (MK-1439A-028)
Status: COMPLETED
Conditions: HIV-1|Central Nervous System
Interventions: DRUG: Doravirine, Tenofovir, Lamivudine - Blinded|DRUG: Doravirine, Tenofovir, Lamivudine - Open-Label|DRUG: ATRIPLA^TM|DRUG: Placebo to ATRIPLA™|DRUG: Placebo to Doravirine, Tenofovir, Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Whole Body Vibration Training in Patients After Lung Transplantation
Status: COMPLETED
Conditions: Patients Following Lung Transplantation (Single and Double)
Interventions: OTHER: Pulmonary rehabilitation + whole body vibration training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid-free Analgesia in Intensive Care Unit
Status: RECRUITING
Conditions: Intubation
Interventions: DRUG: OFA multimodal analgesia|DRUG: Standard multimodal analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise-based Telerehabilitation in the Cardiac Rehabilitation Program
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DEVICE: Exercise telemonitoring connects to healthcare platform|DEVICE: Exercise self-monitoring|DEVICE: Exercise teleconsultation|PROCEDURE: Other CR components|PROCEDURE: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: IMM2510, a PD-L1 and VEGF Bispecific Fusion Protein, in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: IMM2510
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Protocol Posturalchanges in Women Giving Birth With Epidural Analgesia. Clinical Trial.
Status: RECRUITING
Conditions: Epidural Analgesia|Nulliparous Pregnant|Labor With Postural Changes|Randomized
Interventions: OTHER: postural changes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study With Information Technology (IT) - Aided Preventive Program in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: antipsychotic dose increase|OTHER: no intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Daptomycin and Cytokines Production in Comparison With Vancomycin
Status: COMPLETED
Conditions: Cellulitis
Interventions: DRUG: Daptomycin|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Additive Effect of Twice-daily Brinzolamide 1%/Brimonidine 0.2%Combination as an Adjunctive Therapy to Travoprost in Patients With Normal Tension Glaucoma
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: brinzolamide 1%/brimonidine 0.2% fixed combination|DRUG: Placebo|DRUG: travoprost 0.004% ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT