pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Prospective Randomized Open Label Study of the Treatment of Therapy-associated Diarrhea During Percutaneous Radiation Therapy of the Small Pelvis. - Comparison of Loperamide and Tincture of Opium -
Status: TERMINATED
Conditions: Diarrhea|Enteritis|Cancer
Interventions: DRUG: Opii normata treatment|DRUG: Loperamid Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multimodal Intervention Program to Improve Sexual Health and Self-perceived Quality of Life in Patients Treated for Cervical Cancer (PROVIDENCE)
Status: NOT_YET_RECRUITING
Conditions: Cervical Cancer|Sexual Dysfunction|Quality of Life
Interventions: COMBINATION_PRODUCT: Multimodal intervention on sexual dysfunction and quality-of-life
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bexarotene, Tretinoin, and Combination Chemotherapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: bexarotene|DRUG: capecitabine|DRUG: carboplatin|DRUG: cisplatin|DRUG: docetaxel|DRUG: tretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Sonic Activation of Root Sealers on Post-Operative Pain
Status: COMPLETED
Conditions: Post Operative Pain|Apical Periodontitis
Interventions: PROCEDURE: Root canal treatment (AH Plus-NA)|PROCEDURE: Root canal treatment (AH Plus-EA)|PROCEDURE: Root canal treatment (BC-NA)|PROCEDURE: Root canal treatment (BC-EA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Gabapentin for Pain Control After Osmotic Dilator Insertion and Prior to D&E Procedure: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Abortion, Induced|Cervical Preparation|Pain
Interventions: DRUG: Gabapentin 600mg|DRUG: Placebo oral capsule|DRUG: acetaminophen/codeine and ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Response to Acthar Gel Therapy in Patients Who Failed Intravenous Methylprednisolone (IVMP) for MS Relapses
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: DRUG: Acthar Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adherence to Topical Hydrocortisone 17-butyrate 0.1% (Locoid®) Using Different Vehicles in Adults With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: hydrocortisone 17-butyrate 0.1% Cream preparation|DRUG: hydrocortisone 17-butyrate 0.1% Ointment preparation|DRUG: hydrocortisone 17-butyrate 0.1% Lipocream preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of 5%NaHCO3, 2%CHG and 70%Alcohol in the Prevention of Infections Related to Catheter
Status: COMPLETED
Conditions: Disinfectant Dye Adverse Reaction|Catheter-Related Infections|Nursing Caries|Children, Only|Skin Lesion|Chlorhexidine Adverse Reaction|Catheter
Interventions: DRUG: Skin antisepsis with 5% NaHCO3 water solution|DRUG: Skin antisepsis with 2% Chlorhexidine Gluconate solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Addition of Temozolomide to Conditioning for Autologous Transplantation in Relapsed & Refractory CNS Lymphoma
Status: TERMINATED
Conditions: B-Cell Lymphoma Originating in the CNS
Interventions: DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMPACT- 24Bt Post Mech. Thrombectomy and/or rtPA TRIAL IMPlant Augmenting Cerebral Blood Flow 24 Hours From Stroke Onset
Status: TERMINATED
Conditions: Ischemic Stroke
Interventions: DEVICE: The Ischemic Stroke System|DEVICE: Sham control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decitabine-primed Tandem CD19/CD20 CAR T Cells Plus Epigenetic Agents in Aggressive r/r B-NHL With Huge Tumor Burden
Status: UNKNOWN
Conditions: Refractory or Relapsed Aggressive r/r B-NHL With Huge Tumor Burden
Interventions: DRUG: Chidamide|DRUG: Decitabine|DRUG: Chidamide and Decitabine|BIOLOGICAL: Decitabine-primed Tandem CAR19/20 engineered T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Value of Screening and Treatment of SAHS in the Management of AF Ablation Candidates
Status: UNKNOWN
Conditions: Atrial Fibrillation Paroxysmal|Atrial Fibrillation, Persistent|Apnea Syndrome|Hypopnea Syndrome
Interventions: OTHER: Treatment of SAHS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Feasibility Study of the Adult Congenital Heart Disease-Coping and Resilience (ACHD-CARE) Trial
Status: COMPLETED
Conditions: Heart Defects, Congenital
Interventions: BEHAVIORAL: ACHD-CARE Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Dopamine Levels Before and After Weight Restoration in People With Anorexia Nervosa
Status: COMPLETED
Conditions: Eating Disorders
Interventions: RADIATION: Positron Emission Tomography (PET) using [11C]raclopride|DRUG: Methylphenidate|PROCEDURE: Magnetic Resonance Imaging (MRI) scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cognitive-behavioral Therapy for Mental Disorder in COVID-19 Survivors
Status: RECRUITING
Conditions: Post Acute COVID-19 Syndrome
Interventions: BEHAVIORAL: mindfulness-based stress reduction (MBSR) and cognitive behavioral therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psyllium Fiber Versus Placebo in Early Treatment After STARR for Obstructed Defecation: a Double-blind RCT
Status: COMPLETED
Conditions: Constipation|Incontinence
Interventions: DRUG: Psyllium fiber|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Hypersensitivity to Phosphodiesterase 3 Inhibition in Post-Traumatic Headache
Status: RECRUITING
Conditions: Post-Traumatic Headache
Interventions: DRUG: Cilostazol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of the Noxsano Wound Care Bandage
Status: TERMINATED
Conditions: Wound Heal|Peripheral Artery Disease|Ulcer, Leg|Ulcer Foot|Diabetic Foot Ulcer|Arterial Insufficiency
Interventions: DEVICE: Noxsano Bandage (Healthy Volunteers)|DEVICE: Noxsano Bandage (Wound Care)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Juxta-CuresTM Versus Bandaging for Venous Ulcers
Status: COMPLETED
Conditions: Venous Ulcer
Interventions: DEVICE: Juxta-Cures™|DEVICE: Standard Compression|DEVICE: PicoPress®|DEVICE: Silhoutte® 3D wound imaging system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigate the Safety, Tolerability and Pharmacokinetics of FBL-MTX
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: FBL-MTX|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Tolerability and Pharmacokinetic Study of Econazole Nitrate and Benzydamine HCl Intravaginal Cream
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Econazole nitrate 1% plus Benzydamine HCl 0.12% intravaginal cream|DRUG: Placebo plus Econazole nitrate 1% intravaginal cream|DRUG: Placebo plus Benzydamine HCl 0.12% intravaginal cream|DRUG: Placebo intravaginal cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate Automated Intensity Management in Patients Undergoing a BSC SCS Temporary Trial
Status: RECRUITING
Conditions: Chronic Pain|Intractable Pain|Low Back Pain|Pain, Neuropathic|Pain, Back
Interventions: DEVICE: Spinal Cord Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Soft Tissue Augmentation Using CAF With Either SCTG and Vitamin C Versus SCTG Alone in Management of RT1 Gingival Recession
Status: UNKNOWN
Conditions: Gingival Thickness
Interventions: PROCEDURE: CAF with SCTG and Vitamin C injection|PROCEDURE: CAF with SCTG alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of PEMF to Evaluate VPT and Thermal Sensory in Subjects With Diabetic Peripheral Neuropathy
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathy
Interventions: DEVICE: Active Provant Therapy System|DEVICE: Inactive (sham) Provant Therapy System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Deep Anaesthesia With Isoflurane as a Fast-response Antidepressant Agent
Status: UNKNOWN
Conditions: Depressive Disorder, Major|Treatment Resistant Depression|Depressive Episode
Interventions: DRUG: Isoflurane|DRUG: Sertraline Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Cohort Study Evaluating the Efficacy of PO Magnesium in the Treatment of Acute Traumatic Brain Injury in Adolescents
Status: COMPLETED
Conditions: Concussion Post Syndrome
Interventions: DRUG: Magnesium Oxide|DRUG: Acetaminophen|DRUG: Zofran ODT 4 MG Disintegrating Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Transplantation of Autologous Olfactory Ensheathing Cells in Complete Human Spinal Cord Injury
Status: UNKNOWN
Conditions: Complete Spinal Cord Injuries
Interventions: PROCEDURE: olfactory mucosa ensheathing cell grafting, rehabilitation|OTHER: rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Heart Failure - Cheyne Stokes Respiration - CS2 (3C-study)
Status: COMPLETED
Conditions: Heart Failure|Cheyne Stokes Respiration
Interventions: DEVICE: ASV|OTHER: without Autoset CS2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of Naloxone 5 Milligrams (mg) Intramuscular (IM) Autoinjector
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: NaxRedy ™|DRUG: Naloxone Hydrochloride Injection, USP|DRUG: Naloxone Hydrochloride Injection, USP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase I, Randomized, Open-label, Cross-over, Pharmacokinetic Study of Genasense With and Without Dacarbazine
Status: COMPLETED
Conditions: Advanced Melanoma
Interventions: DRUG: Genasense® (G3139, oblimersen sodium)|DRUG: Genasense followed by DTIC; then DTIC alone|DRUG: DTIC alone; then Genasense followed by DTIC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Peri-operative Pregabalin After Radical Cystectomy
Status: COMPLETED
Conditions: Postoperative Pain Following Radical Cystectomy
Interventions: DRUG: pregabaline 300 mg once.|DRUG: pregabaline 300 mg twice.|DRUG: pregabaline 600 mg once.|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy & Safety of Eszopiclone (Lunesta) in Nursing Home Patients
Status: COMPLETED
Conditions: Poor Quality Sleep
Interventions: DRUG: Lunesta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maximizing Outcomes for Preschoolers With Developmental Language Disorders
Status: ACTIVE_NOT_RECRUITING
Conditions: Developmental Language Disorder
Interventions: BEHAVIORAL: the Enhanced Milieu Teaching-Sentence Focus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lycopene and Beta-carotene Metabolism in the Digestive Tract of Healthy Men
Status: COMPLETED
Conditions: Digestion Chambers|Stability and Metabolism of Carotenoids and Vitamin E
Interventions: OTHER: lycopene|OTHER: beta-carotene|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ultrasound-guided Subclavian Vein Puncture Versus Cephalic Vein Dissection for Venous Access Port Implantation
Status: WITHDRAWN
Conditions: Vascular Surgical Procedures
Interventions: PROCEDURE: Ultrasound-guided subclavian vein puncture|PROCEDURE: Cephalic vein dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing Biomarkers of Dietary Intake
Status: COMPLETED
Conditions: Diet Therapy|Healthy Volunteers
Interventions: OTHER: 1. Meat, no fish or soda|OTHER: 2. Meat and soda, no fish|OTHER: 3. Meat and fish, no soda|OTHER: 4. Meat and fish and soda|OTHER: 5. Fish, no meat or soda|OTHER: 6. Fish and soda, no meat|OTHER: 7. No meat, fish or soda|OTHER: 8. Soda, no meat or fish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Lopinavir/Ritonavir or Hydroxychloroquine in Patients With Mild Coronavirus Disease (COVID-19)
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Lopinavir/ritonavir|DRUG: Hydroxychloroquine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Indwelling vs Immediate Removal of Foley Catheter After Robotic Assisted Laparoscopic Sacrocolpopexy: a Prospective Study
Status: COMPLETED
Conditions: Urinary Retention
Interventions: OTHER: No Foley
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Safety and Efficacy of Adeno-IFN Gamma in Cutaneous B-cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma, B-Cell
Interventions: GENETIC: Adenovirus Interferon gamma
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Analgesic Effect of (SHAC) Block Versus Suprascapular Nerve Block in Arthroscopic Shoulder Surgeries
Status: NOT_YET_RECRUITING
Conditions: Shoulder Pain|Postoperative Pain
Interventions: PROCEDURE: SHAC block|PROCEDURE: suprascapular nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Novel mHealth Platform to Ensure Quality of Community-based Malaria Diagnosis
Status: COMPLETED
Conditions: Quality Assurance of Malaria Diagnosis
Interventions: DEVICE: mHealth platform employing Fionet Deki Readers to ensure quality of community-based malaria diagnosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose:
Clinical trial: New Algorithms to Signal Processing for Speech Enhancement in Adult Cochlear Implant Recipients.
Status: RECRUITING
Conditions: Hearing Loss
Interventions: DEVICE: Investigational Pre-Processing Algorithm (Sub A)|DEVICE: Cochlear Limited standard-of-care pre-processing algorithms|DEVICE: Investigational Pre-Processing Algorithm (Sub B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease
Status: NOT_YET_RECRUITING
Conditions: Sickle Cell Disease|Hb-SS Disease|Hemoglobin S|Disease Sickle Cell Anemia|Sickle Cell Disorders|Hemoglobin Beta Thalassemia Disease
Interventions: DRUG: Fostamatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neuroprotection With Phenytoin in Optic Neuritis
Status: COMPLETED
Conditions: Optic Neuritis|Multiple Sclerosis
Interventions: DRUG: Phenytoin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Kudzu Extract in the Study of Its Ability to Reduce Alcohol Drinking in Treatment Seeking Alcohol Dependent Persons
Status: WITHDRAWN
Conditions: Alcohol Abuse|Alcohol Dependence|Heavy Drinking Days
Interventions: DRUG: Kudzu extract|DRUG: Placebo|BEHAVIORAL: Medical Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of NN5401 With Insulin Glargine in Insulin Naive Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec/insulin aspart|DRUG: insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Eplerenone on Markers of Myocardial Fibrosis in Adult Congenital Heart Disease
Status: TERMINATED
Conditions: Tetralogy of Fallot|Transposition of the Great Vessels With an Arterial Switch|Single Ventricle With a Fontan Palliation
Interventions: DRUG: Eplerenone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualized Analgesia for Pediatric Adenotonsillectomy
Status: COMPLETED
Conditions: Adenotonsillectomy|Analgesia
Interventions: DRUG: Individualized oral morphine|DRUG: Conventional oral morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is it Fair to Use Antibiotics After Laparoscopic Cholecystectomy for the Patients With Acutely Inflamed Gallbladder?
Status: COMPLETED
Conditions: Acute Cholecystitis
Interventions: DRUG: Cephalosporin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab in Association With Radiotherapy and Cisplatin in Locally Advanced Cervical Cancers Followed by Adjuvant Nivolumab for up to 6 Months
Status: COMPLETED
Conditions: Cervical Cancer|Locally Advanced Cervical Cancer
Interventions: DRUG: Nivolumab Injection|DRUG: Cisplatin|RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men to Compare 2 Different Formulations of Alteplase
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Alteplase (from modified manufacturing process)|DRUG: Alteplase (from current manufacturing process)|DRUG: Heparin-Natrium-5000-ratiopharm (unfractionated heparin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Combined Antioxidant Therapy on Oxidative Stress Markers and Inflammatory Cytokines in Patients With Tinnitus
Status: RECRUITING
Conditions: Tinnitus, Subjective|Tinnitus, Bilateral|Antioxidant Therapy|Psychiatric Drugs|Oxidative Stress|Inflammatory Cytokines|SSRI
Interventions: DIETARY_SUPPLEMENT: Drusen Mega®|DRUG: Sertraline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Design of Personalised supplemenTs Based on the Gut micRobiota Through Artificial Intelligence for Alzheimer's Patients
Status: RECRUITING
Conditions: Alzheimer Disease|Gut Microbiota
Interventions: DIETARY_SUPPLEMENT: Personalized diet|DIETARY_SUPPLEMENT: Dietary counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of a Single Dose of NBI-98854 in Subjects With Mild,Moderate, or Severe Hepatic Insufficiency
Status: COMPLETED
Conditions: Safety, Tolerability, and PK of NBI-98854 in Hepatically Impaired Subjects
Interventions: DRUG: NBI-98854 50 mg capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Personal Versus Video Instruction in Elastic Resistance Exercise on Technical Execution (IRMA05)
Status: COMPLETED
Conditions: Musculoskeletal Disorders
Interventions: BEHAVIORAL: Video instruction|BEHAVIORAL: Personal instruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Online Aerobic Exercise Training and Physical Activity Counseling in Juvenile Familial Mediterranean Fever
Status: UNKNOWN
Conditions: Familial Mediterranean Fever|Exercise|Physical Activity
Interventions: OTHER: Online Aerobic Dance Exercises|OTHER: Physical Activity Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: TAP Block With Methyl-prednisolone as a Pain Treatment Modality After Total Abdominal Hysterectomy Procedures
Status: COMPLETED
Conditions: Local Anesthetic|Ultrasound|Pain, Acute
Interventions: DRUG: TAPB with dexamethasone as an adjuvant to local anesthetics|DRUG: TAPB with methylprednisolone as an adjuvant to local anesthetics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: S0709: Erlotinib With or Without Carboplatin and Paclitaxel in Stage IIIB or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: erlotinib hydrochloride|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Clinical Efficacy of Belting Stabilization for Shoulder Pain
Status: COMPLETED
Conditions: Rotator Cuff Impingement Syndrome
Interventions: PROCEDURE: Stabilization belt|PROCEDURE: Stabilization belt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ARCTIC: Liquid Biomarkers in the Prospective Androgen Receptor Signaling Inhibitors (ARSI) Resistance Clinical Trials
Status: RECRUITING
Conditions: Prostate Cancer|Prostate Adenocarcinoma|Prostate Cancer Metastatic|Castration-resistant Prostate Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Inhibitory Control of the Mind : Neural Bases and Impact for Obsessive-compulsive Disorders
Status: UNKNOWN
Conditions: Obsessive Compulsive Disorder|Healthy
Interventions: OTHER: Functional magnetic resonance imaging|BEHAVIORAL: behavioral measures|OTHER: physiological measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study In Adults With Moderate To Severe Dermatomyositis
Status: COMPLETED
Conditions: Dermatomyositis
Interventions: DRUG: PF-06823859 low|DRUG: Placebo Arm|DRUG: PF-06823859 high
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study Comparing 10 mg Amlodipine Besylate Orally Disintegrating Tablets (ODT) And 10 mg Amlodipine Besylate Capsules
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Amlodipine - reference|DRUG: Amlodipine ODT - test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impacts of a Standardized Musical Intervention on Complex Dressing Care During Home Hospitalization (MUCAFOCSS)
Status: WITHDRAWN
Conditions: Bandage|Pain|Anxiety
Interventions: OTHER: Youtube© relaxation music|DEVICE: MUSIC CARE© intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy Study of Sofosbuvir Plus Ribavirin in Treatment-Naive Adults With Genotype 1 and 3 Chronic HCV Infection
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: SOF|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of the Combination of Pertuzumab With Carboplatin-Based Standard Chemotherapy in Patients With Recurrent Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: pertuzumab|DRUG: paclitaxel|DRUG: gemcitabine|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Safety, Tolerability, And Action Of OAP-189 In Subjects With Type 2 Diabetes On Metformin
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: OAP-189|DRUG: placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Statin Therapy on C-reactive Protein Levels in Patients With Chronic Obstructive Lung Disease (COPD)
Status: COMPLETED
Conditions: COPD|Inflammation
Interventions: DRUG: simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Performance and Potential Benefits of an Assistive Artificial Intelligence Device ScanNav Anatomy Peripheral Nerve Block - US V1.0 for Ultrasound-guided Regional Anesthesia
Status: COMPLETED
Conditions: Ultrasound Imaging of Anatomical Structures
Interventions: DEVICE: Ultrasound scanning
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of No-carrageenan Diet on Glucose Tolerance in Prediabetes
Status: COMPLETED
Conditions: Prediabetes
Interventions: OTHER: No-carrageenan diet|OTHER: Regular Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Music Therapy For The Treatment Of Cisplatin Induced Tinnitus In Patients With rGCC: A Pilot Study
Status: WITHDRAWN
Conditions: Relapsed Germ Cell Cancer|Cisplatin Induced Tinnitus
Interventions: BEHAVIORAL: Modified Heidelberg Model of Neuro-Music Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety Study of OPC-12759 Ophthalmic Solution
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: OPC-12759 Ophthalmic solution|DRUG: OPC-12759 Ophthalmic suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Capsulectomy, Performed in Total Hip Arthroplasty With a Direct Anterior Approach Cause Knee Extension Strength Loss?
Status: UNKNOWN
Conditions: Coxarthrosis|Muscle Weakness
Interventions: PROCEDURE: Capsulotomy with Repair|PROCEDURE: Capsuloectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Oral Testosterone Undecanoate Followed by Enzalutamide as Therapy for Men With Metastatic Castrate Resistant Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer|Castration-resistant Prostate Cancer|Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: Testosterone Undecanoate|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of CC-99677 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: CC-99677|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Demonstrate Safety and Duration of Effect of 40 Units of PrabotulinumtoxinA-xvfs to Treat Glabellar Lines
Status: COMPLETED
Conditions: Glabellar Frown Lines
Interventions: DRUG: PrabotulinumtoxinA-Xvfs|DRUG: OnabotulinumtoxinA|DRUG: PrabotulinumtoxinA-Xvfs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment for Antepartum Posttraumatic Stress Disorder/PTSD Study
Status: RECRUITING
Conditions: PTSD
Interventions: BEHAVIORAL: Written Exposure Therapy (WET)|BEHAVIORAL: Emotion Focused Supportive Therapy (EFST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CBT Training for Cognitive Reappraisal as an Intervention for Patients With Functional Tremor - an EEG Study
Status: RECRUITING
Conditions: Functional Movement Disorder
Interventions: BEHAVIORAL: Cognitive Reappraisal|BEHAVIORAL: Reflection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine and Chemotherapy for Previously Untreated Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Neoplasms|Metastases, Neoplasm
Interventions: BIOLOGICAL: recombinant fowlpox-CEA(6D)/TRICOM vaccine|BIOLOGICAL: recombinant vaccinia-CEA(6D)/TRICOM vaccine|BIOLOGICAL: filgrastim|BIOLOGICAL: sargramostim|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: fludarabine phosphate|DRUG: paclitaxel|DRUG: Mesna
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment for Major Depressive Disorder With Intermittent Theta-burst Stimulation
Status: UNKNOWN
Conditions: Depressive Disorder, Treatment-Resistant
Interventions: DEVICE: iTBS-1800|DEVICE: iTBS-1200
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease
Status: COMPLETED
Conditions: Degenerative Disc Disease
Interventions: DEVICE: Accu-Spina Device/IDD therapy|PROCEDURE: Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transient Elastograghy to Detect Non Alcoholic Fatty Liver Disease in Renal Transplantation Recipients.
Status: NOT_YET_RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease|Renal Transplant Complication Pre-Existing Disease
Interventions: DEVICE: transient elastograghy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Fentanyl ETHYPHARM for Breakthrough Pain in Opioid-treated Patients With Cancer
Status: COMPLETED
Conditions: Breakthrough Pain|Cancer
Interventions: DRUG: Fentanyl Ethypharm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Innoventric Trillium™ Stent Graft Early Feasibility Study (EFS)
Status: NOT_YET_RECRUITING
Conditions: Tricuspid Regurgitation|Tricuspid Regurgitation Functional
Interventions: DEVICE: Trillium™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Nature-based, Self-help Intervention on Mental Wellbeing
Status: RECRUITING
Conditions: Low Mental Wellbeing
Interventions: BEHAVIORAL: Roots and Shoots|BEHAVIORAL: Waiting list
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Biospecimen Collection Study in BRAF-V600E Mutated Recurrent Gliomas
Status: TERMINATED
Conditions: Glioma|BRAF V600E|Pleomorphic Xantho-Astrocytoma|Glioblastoma
Interventions: PROCEDURE: Surgical Cohort
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Compare IPX066 and Carbidopa/Levodopa/Entacapone (CLE) Followed by an Open-Label Safety Study of IPX066
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: IPX066|DRUG: CLE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Preoperative Inhaled Budesonide With Salbutamol on the Respiratory Adverse Effects in Children Undergoing Tonsillectomy
Status: NOT_YET_RECRUITING
Conditions: Preoperative Inhalation of Budesonide and Salbutamol in Children Undergoing Tonsillectomy
Interventions: DRUG: Salbutamol|DRUG: Budesonide|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Denosumab as an add-on Neoadjuvant Treatment (GeparX)
Status: COMPLETED
Conditions: Breast Cancer Female NOS|Tubular Breast Cancer Stage II|Mucinous Breast Cancer Stage II|Invasive Ductal Breast Cancer|HER2 Positive Breast Cancer|Inflammatory Breast Cancer|Tubular Breast Cancer Stage III
Interventions: DRUG: Denosumab|DRUG: nab-Paclitaxel|DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: Carboplatin|DRUG: Trastuzumab|DRUG: Pertuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of L-citrulline in Prevention of Pregnancy Associated Hypertension
Status: SUSPENDED
Conditions: Pregnancy Induced Hypertension|Preeclampsia and Eclampsia|Gestational Hypertension
Interventions: DRUG: L-citrulline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Using PET Scans to Study Brain Receptor Occupancy of BIIB014 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIIB014|OTHER: [11C]SCH442416
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PRECISE, a Study to Gather More Information About Bone Fractures and Survival in Castration-resistant PRostate Cancer (CRPC) patiEnts Treated With Radium-223 in Routine Clinical practIce in SwedEn
Status: COMPLETED
Conditions: Metastatic Castration-Resistant Prostate Cancer
Interventions: DRUG: Radium-223 dichloride (Xofigo, BAY88-8223)|DRUG: Other standard care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pomegranate Supplementation on Physical Function and Cardiovascular Disease Risk in CKD Patients
Status: COMPLETED
Conditions: Chronic Kidney Disease|Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: Pomegranate extracts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study to Evaluate the Safety and Tolerability of JS107 in Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: JS107|DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of a Health Education Intervention to Reduce Anxiety in Quarantined COVID-19 Patients
Status: COMPLETED
Conditions: Health Education, COVID-19, Quarantine, Anxiety, Pandemic
Interventions: OTHER: health education intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Double Blind, Placebo-controlled Trial to Establish Safety and Efficacy of Ritlecitinib in Celiac Disease Patients in Remission
Status: RECRUITING
Conditions: Celiac Disease
Interventions: DRUG: Ritlecitinib|DRUG: Placebo|OTHER: Gluten
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation Using MED3000 Gel or Tadalafil Tablets in the Treatment of Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DEVICE: MED3000 (Male)|DRUG: Tadalafil 5mg (Male)|DEVICE: MED3000 (Female)|DRUG: Tadalafil 5mg (Female)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anit-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
Status: COMPLETED
Conditions: Hypoalbuminemia|Protein-energy Malnutrition|Inflammation|Oxidative Stress|Chronic Kidney Disease (CKD) Hemodialysis
Interventions: DRUG: pentoxiphylline|DIETARY_SUPPLEMENT: Nepro|DIETARY_SUPPLEMENT: anti-inflammatory module (similar to Oxepa)|DRUG: Placebo pill imitating pentoxiphylline|DIETARY_SUPPLEMENT: Placebo to imitate Nepro|DIETARY_SUPPLEMENT: Placebo to imitate anti-inflammatory module (similar to Oxepa)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vacuum Assisted Wound Closure (VAWC) and Mesh Mediated Fascial Traction
Status: COMPLETED
Conditions: Open Abdomen|Fascial Closure
Interventions: PROCEDURE: VAWC and mesh mediated fascial traction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study of Bioavailability of 3 New Abiraterone Acetate Tablets With Current Commercial Tablet
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Abiraterone acetate, 250 mg (uncoated, current commercial tablet)|DRUG: Abiraterone acetate, 500 mg (coated, reformulated tablet)|DRUG: Abiraterone acetate, 250 mg (coated, reformulated tablet)|DRUG: Abiraterone acetate, 500 mg (coated tablet, slower in vitro dissolution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caremap: A Digital Personal Health Record for Complex Care Coordination
Status: ACTIVE_NOT_RECRUITING
Conditions: Children/Youth With Special Healthcare Needs|Adults With Multiple Chronic Conditions
Interventions: OTHER: Caremap app
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Photobiomodulation on Changes in Cognitive Function and rCBF in MCI
Status: COMPLETED
Conditions: Regional Cerebral Blood Flow|Mild Cognitive Impairment|Cognitive Function
Interventions: DEVICE: Photobiomodulation device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Combined HAPA and mHealth Intervention to Reduce Sedentary Behaviour in University Students
Status: COMPLETED
Conditions: Sedentary Lifestyle|Health Behaviour Change
Interventions: BEHAVIORAL: (SB-related planning + daily text messages)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability and Immunogenicity of Pneumovax 23 in Healthy Adults in India (V110-011)
Status: COMPLETED
Conditions: Pneumococcal Infection
Interventions: BIOLOGICAL: Pneumococcal Vaccine, Polyvalent (23-valent)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Esketamine Combined With Pregabalin on Chronic Postsurgical Pain in Patients After Craniotomy.
Status: COMPLETED
Conditions: Chronic Postsurgical Pain
Interventions: DRUG: S-ketamine and pregabalin|DRUG: Normal saline and placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect and Benefit of Diabetes Management Decision Support Software for Blood Glucose Control
Status: UNKNOWN
Conditions: Diabetes Mellitus
Interventions: OTHER: Medication Management Clinic|OTHER: Diabetes+Me plus connected glucometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Efficacy and Safety of HRG2005 Inhalation in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: HRG2005 inhalation|DRUG: Placebo to match HRG2005 inhalation|DRUG: Placebo to match Indacaterol Maleate and Glycopyrronium Bromide Powder for inhalation|DRUG: Indacaterol Maleate and Glycopyrronium Bromide Powder for inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mat Pilates in Women With Breast Cancer During Adjuvant Radiotherapy
Status: COMPLETED
Conditions: Breast Cancer|Adjuvant Radiotherapy
Interventions: OTHER: Pilates Exercise|OTHER: Home exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study for Geko Device in VLU Patients (Canada)
Status: TERMINATED
Conditions: Venous Leg Ulcer|Leg Ulcer|Venous Ulcer
Interventions: DEVICE: geko
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Added Benefit of L-PRF to Autogenous Bone Graft in the Treatment of Mandibular Degree II Furcation Defects
Status: COMPLETED
Conditions: Periodontal Attachment Loss|Periodontal Bone Loss
Interventions: PROCEDURE: Periodontal Surgery with OFD+ABG+L-PRF|PROCEDURE: Periodontal Surgery with OFD+ABG|PROCEDURE: Periodontal Surgery OFD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CD19 CAR-T Cells With CRS Suppression Technology for r/r CD19+ Acute Lymphoblastic Leukemia
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia|CD19 Positive|Relapse|Refractory
Interventions: BIOLOGICAL: CD19 CAR-T cells|BIOLOGICAL: CD19 CAR-T cells with CRS suppression technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of iPACK After Unilateral TKA
Status: COMPLETED
Conditions: Arthroplasty Complications|Pain, Joint|Arthritis Knee|Regional Anesthesia Morbidity
Interventions: PROCEDURE: iPACK|PROCEDURE: Periarticular local infiltration analgesia (LIA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: This Study Will Compare the Efficacy and Safety of SCT510A Administered by Intravitreal Injection (IVT) With Ranibizumab in Patients With wAMD
Status: RECRUITING
Conditions: Wet Age-related Macular Degeneration
Interventions: DRUG: Ranibizumab|DRUG: SCT510A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diet Restriction and Exercise-induced Adaptations in Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Short-term diet and exercise intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE