pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Conditioning Regimen Containing Melphalan and Cladribine for Refractory / Relapsed AML
Status: NOT_YET_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: MCBC regimen|DRUG: Bu/Cy regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Effectiveness of the Artificial Cervical Disc - Low Profile Device at Two Adjacent Levels
Status: COMPLETED
Conditions: Cervical Degenerative Disc Disease|Radiculopathy|Myelopathy
Interventions: DEVICE: PRESTIGE LP device at two adjacent levels|DEVICE: Bi-level fusion with ATLANTIS Cervical Plate System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Response Study to Evaluate the Effect of BKR-017 on Insulin Resistance and Other Metabolic Parameters in Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: BKR-017
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Micafungin Versus Amphotercine B in Treatment of Invasive Fungal Infection
Status: COMPLETED
Conditions: Neonatal Infection|Invasive Fungal Infections
Interventions: DRUG: Micafungin|DRUG: Amphotericin B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Priming With Live Attenuated A/H7N9 Influenza Virus Vaccine Followed By Inactivated A/H7N9 Influenza Virus Vaccine With AS03 Adjuvant
Status: COMPLETED
Conditions: Influenza A Virus, H7N9 Subtype
Interventions: BIOLOGICAL: H7N9 pLAIV|BIOLOGICAL: H7N9 pIIV|BIOLOGICAL: AS03 adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PH 1 Evaluation Of Oral CI-1033 In Combination With Paclitaxel/ Carboplatin As 1st Line Chemotherapy In NSCLC Patients
Status: COMPLETED
Conditions: Carcinoma, Non-Small Cell Lung
Interventions: DRUG: CI 1033|DRUG: PACLITAXEL|DRUG: CARBOPLATIN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Remission MAINtenance Using Extended Administration of Prednisone in Systemic Anti-neutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis.
Status: UNKNOWN
Conditions: Granulomatosis With Polyangitis
Interventions: DRUG: Prednisone 5mg/day extended of 12 additional months|DRUG: Placebo 5mg/day extended of 12 additionnal months.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Diagnostic Yield and Safety of Transbronchial Cryobiopsy in The Pulmonary Periphral Nodule
Status: UNKNOWN
Conditions: Diagnosis|Complication Rate
Interventions: PROCEDURE: Transbronchial cryobiopsy/Transbronchial lung biopsy (forcep)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Ecopipam or Placebo in Adults With Stuttering (Speak Freely)
Status: COMPLETED
Conditions: Childhood-Onset Fluency Disorder (Stuttering)
Interventions: DRUG: Ecopipam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Augmentation of Immune Response to COVID-19 mRNA Vaccination Through OMT With Lymphatic Pumps
Status: COMPLETED
Conditions: Covid19
Interventions: OTHER: Osteopathic Manipulative Treatment (OMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Working on Asymmetry in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: BEHAVIORAL: Physical Therapy WSI|BEHAVIORAL: Physical Therapy BSI|BEHAVIORAL: Physical Therapy ST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Laparoscopic Hysterectomy Simulator
Status: COMPLETED
Conditions: Evaluation of Laparoscopic Hysterectomy Simulator
Interventions: PROCEDURE: Laparoscopic Hysterectomy trainer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Autologous PRP Infusion May Restore Ovarian Function and May Promote Folliculogenesis in POI Patients
Status: RECRUITING
Conditions: Menopause, Premature|Menopause Related Conditions|Menopausal Syndrome|Premature Ovarian Failure|Ovarian Failure, Premature
Interventions: BIOLOGICAL: Autologous Platelet Rich Plasma|BIOLOGICAL: Placebo-Platelet Free Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eplerenone in HIV Associated Abdominal Fat Accumulation
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Eplerenone and lifestyle|OTHER: placebo and lifestyle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of AZD2171 in Combination With AZD0530 in Patients With Advanced Solid Tumours
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: AZD2171|DRUG: AZD0530
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Depth of Anaesthesia and Postoperative Cognitive Decline in Patients Undergoing Heart Surgery
Status: COMPLETED
Conditions: Cardiac Bypass Surgery in Adult Patients 65 Years and Older|Postoperative Cognitive Dysfunction|Postoperative Delirium
Interventions: OTHER: Targeted intra-operative depth of anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple Myeloma/Chronic Lymphocytic Leukemia Coach RCT
Status: COMPLETED
Conditions: Multiple Myeloma|Chronic Lymphocytic Leukemia
Interventions: OTHER: Myeloma Coach or CLL Coach Mobile App|OTHER: Springboard Beyond Cancer informational website
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of a Monthly High Dose of Vitamin D3 on Bariatric Surgery Patients
Status: COMPLETED
Conditions: Morbid Obesity|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: vitamin D3 (Replesta)|DIETARY_SUPPLEMENT: vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CORT125281 Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CORT125281, 40mg, fasted|DRUG: Prednisone 25mg, fasted|DRUG: Placebo oral capsule, fasted|DRUG: Pioglitazone 15mg Tablet|DRUG: Placebo oral capsule, fed|DRUG: Prednisone 25mg, fed|DRUG: CORT125281, 120mg, fasted|DRUG: CORT125281, 360mg, fasted|DRUG: CORT125281, 720mg, fasted|DRUG: CORT125281, 360mg, fed|DRUG: CORT125281, 360mg|DRUG: CORT125281, 120mg|DRUG: CORT125281, 180mg|DRUG: CORT125281, 240mg|DRUG: CORT125281, 360mg|DRUG: Placebo oral capsule|DRUG: Placebo oral capsule|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Testing the Addition of the Anti-cancer Drug, Tazemetostat, to the Usual Treatment (Dabrafenib and Trametinib) for Metastatic Melanoma That Has Progressed on the Usual Treatment
Status: RECRUITING
Conditions: Clinical Stage IV Cutaneous Melanoma AJCC v8|Metastatic Melanoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Computed Tomography|DRUG: Dabrafenib Mesylate|PROCEDURE: Echocardiogram Recording|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Multigated Acquisition Scan|DRUG: Tazemetostat Hydrobromide|DRUG: Trametinib Dimethyl Sulfoxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rhenium Re 188 P2045 in Patients With Lung Cancer Who Have Received or Refused to Receive Prior Chemotherapy
Status: RECRUITING
Conditions: Lung Neoplasms|Carcinoma, Non-Small-Cell Lung|Carcinoma, Small Cell|Neoplasm Recurrence, Local
Interventions: DRUG: Rhenium (Re 188 P2045, BAY86-5284)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VR-CAP in the First-line Treatment for Patients With Marginal Zone Lymphoma
Status: RECRUITING
Conditions: Marginal Zone Lymphoma
Interventions: DRUG: Bortezomib|DRUG: Rituximab|DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Study Of Amlodipine 10mg With Hypertension For Whom Amlodipine 5mg Is Insufficient
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of PTSD by Reduction of Traumatic Memory Reconsolidation by Propranolol : a Multisite Trial
Status: COMPLETED
Conditions: Post-traumatic Stress Disorder
Interventions: DRUG: Propranolol|OTHER: Trauma reactivation|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Adalimumab in Participants With Peripheral Spondyloarthritis (SpA)
Status: COMPLETED
Conditions: Peripheral Spondyloarthritis
Interventions: BIOLOGICAL: Adalimumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Can 3D Ultrasound Be Used Reproducibly by Radiation Therapists in Partial Breast Image-Guided Radiation Therapy
Status: COMPLETED
Conditions: Radiation Therapy for Primary Breast Cancer
Interventions: PROCEDURE: Image-Guided Radiation Therapy using 3D Ultrasound Guided-Therapy|PROCEDURE: Ultrasound Guided Imaging|PROCEDURE: 3 DUS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NCI COVID-19 in Cancer Patients, NCCAPS Study
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19 Infection|Hematopoietic and Lymphatic System Neoplasm|Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Data Collection|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fecal Microbiota Transplantation (FMT) to Decolonize Antibiotic - Resistant Bacteria (ARB) - New Protocol
Status: RECRUITING
Conditions: Drug Resistance, Bacterial|Antimicrobial Drug Resistance
Interventions: PROCEDURE: Fecal Microbiota Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodal Analgesic Using Morphine and COX-2 With or Without Dexmedetomidine for Colorectal Surgery
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Dexmedetomidine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Tolerability, Pharmacokinetics, and Preliminary Efficacy of HC-1119 in Patients.
Status: COMPLETED
Conditions: Metastatic Castration Resistant Prostate Cancer
Interventions: DRUG: HC-1119
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intestinal Permeability and Gastroparesis
Status: WITHDRAWN
Conditions: Gastroparesis|Healthy
Interventions: DIAGNOSTIC_TEST: Labs, urine tests, upper endoscopy with biopsy and confocal laser endomicroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Electromyographic Biofeedback, Aerobic Exercise and Stretching in Fibromyalgia.
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: BEHAVIORAL: Electromyography-Biofeedback (EMG-BFB) training|BEHAVIORAL: Aquatic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Screening for Asymptomatic Portal Vein Thrombosis and Portal Hypertension in Patients With Philadelphia Negative Myeloproliferative Neoplasms
Status: COMPLETED
Conditions: Myeloproliferative Neoplasms (MPN)|Polycythemia Vera (PV)|Essential Thrombocythemia (ET)|Myelofibrosis (MF)
Interventions: PROCEDURE: Upper gastrointestinal endoscopy and Doppler ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effectiveness of Relationship Education for Reducing HIV Incidence Among SGM
Status: RECRUITING
Conditions: Hiv|Chlamydia|Gonorrhea
Interventions: BEHAVIORAL: all2GETHER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors
Status: RECRUITING
Conditions: Bladder Cancer|Head and Neck Squamous Cell Carcinoma|Cancer of the Salivary Gland|Lung Cancer|Breast Cancer|Gastric Cancer|Esophageal Cancer|Colorectal Cancer|Pancreatic Adenocarcinoma|Solid Tumor
Interventions: BIOLOGICAL: CAdVEC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Regularly Transfused, Followed by a 5-Year Extension Period
Status: ACTIVE_NOT_RECRUITING
Conditions: Pediatric Pyruvate Kinase Deficiency|Pediatric Hemolytic Anemia
Interventions: DRUG: Mitapivat|DRUG: Mitapivat-matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rapid Assessment of Bedside BNP In Treatment of Heart Failure (RABBIT)
Status: TERMINATED
Conditions: Heart Failure
Interventions: DEVICE: Triage® B-Type Natriuretic Peptide (BNP) Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison Between Shear Bond Strength of Different Commercial Metal Bracket Brands: an in Vitro Study
Status: COMPLETED
Conditions: Orthodontic Appliance Complication|Shear Strength
Interventions: OTHER: Estimation of Shear Bond Strength
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Different Intra-arterial Catheter Size on Frequency of Optimal Dynamic Response in Radial Arterial Waveform
Status: UNKNOWN
Conditions: Catheters
Interventions: DEVICE: different intra-arterial catheter size
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Instrument Assisted Soft Tissue Mobilization in Female Patients With Myofascial Pain Syndrome
Status: COMPLETED
Conditions: Myofascial Pain|Instrument Assisted Soft Tissue Mobilization
Interventions: OTHER: Instrument Assisted Soft Tissue Mobilization|OTHER: Sham Instrument Assisted Soft Tissue Mobilization|OTHER: Home exercises programe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Dulanermin Administered in Combination With the FOLFOX Regimen and Bevacizumab in Patients With Previously Untreated, Locally Advanced, Recurrent, or Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: FOLFOX regimen|DRUG: bevacizumab|DRUG: dulanermin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Isolagen Therapy in the Treatment of Nasolabial Fold Wrinkles
Status: COMPLETED
Conditions: Bilateral Nasolabial Fold Wrinkles
Interventions: BIOLOGICAL: Autologous Human Fibroblasts (azficel-T)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Lung Cancer
Status: WITHDRAWN
Conditions: Advanced Lung Cancer
Interventions: BIOLOGICAL: Activated CIK and CD3-MUC1 Bispecific Antibody in Treating Lung cancer|PROCEDURE: Cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Avelumab In Combination Regimens That Include An Immune Agonist, Epigenetic Modulator, CD20 Antagonist and/or Conventional Chemotherapy in Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (R/R DLBCL)
Status: TERMINATED
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: BIOLOGICAL: Avelumab|BIOLOGICAL: Utomilumab|BIOLOGICAL: Rituximab|OTHER: Azacitidine|DRUG: Bendamustine|DRUG: Gemcitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-microbial Role of Non-antibiotic Agents Against Cutibacterium Acnes in Patients With Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DIAGNOSTIC_TEST: assess the possible role of Salicylic acid, Isotretinoin, and N-acetylcysteine in improving the susceptibility of C. acne for Azithromycin and Doxycycline.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Caphosol® on the Development of Esophagitis in (N)SCLC Patients Treated With Concurrent Chemo/Radiotherapy
Status: TERMINATED
Conditions: Small Cell Lung Cancer|Non Small Cell Lung Cancer
Interventions: OTHER: Caphosol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study on the Immune Response and Safety of Inactivated Poliovirus Vaccine (IPV) When Co-administered With Human Rotavirus (HRV) Porcine Circovirus (PCV)-Free Vaccine in Healthy Chinese Infants
Status: RECRUITING
Conditions: Gastroenteritis
Interventions: COMBINATION_PRODUCT: HRV PCV-free|COMBINATION_PRODUCT: IPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PERIOPERATIVE TREATMENT WITH COI-B (CAPECITABINE, OXALIPLATIN, IRINOTECAN AND BEVACIZUMAB) OF HIGH RISK OR BORDERLINE RESECTABLE COLORECTAL CANCER LIVER METASTASES
Status: COMPLETED
Conditions: Colorectal Cancer Liver Metastases
Interventions: DRUG: capecitabine, oxaliplatin, irinotecan and bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sphenopalatine Block Versus Greater Occipital Nerve Block in PDPH
Status: RECRUITING
Conditions: Post-Dural Puncture Headache
Interventions: PROCEDURE: bilateral sphenopalatine ganglion block|PROCEDURE: bilateral greater occipital nerve block|DRUG: lidocaine plus dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiologic Effects of Nasal High Flow on Exercise Tolerance in COPD
Status: NOT_YET_RECRUITING
Conditions: COPD
Interventions: DEVICE: Nasal High Flow Cannula|DEVICE: Nasal Low Flow Cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transplantation of Umbilical Cord Blood Following Chemotherapy for Blood Cancers
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|Leukemia, Lymphoblastic, Acute|Leukemia, Bilineage, Acute|Leukemia, Myeloid, Chronic
Interventions: BIOLOGICAL: Ex vivo expansion of cord blood
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ELE-101 Safety & Tolerability Study in Healthy Participants and Patients With Depression
Status: RECRUITING
Conditions: Healthy Volunteers|Major Depressive Disorder|Depression
Interventions: DRUG: ELE-101|DRUG: ELE-101 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Clinical Study to Assess Safety, Efficacy and In-Use Tolerability of Three Different Hair Growth Products in Patients With Mild to Moderate Androgenic Alopecia (Grade I to III)
Status: NOT_YET_RECRUITING
Conditions: Androgenic Alopecia
Interventions: OTHER: SesZen-Bio Serum|OTHER: Minoxidil hair serum (1%)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Lesinurad Tablet Relative Bioavailability
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lesinurad 400 mg (Site 1)|DRUG: Lesinurad 400 mg (Site 2, Lot A)|DRUG: Lesinurad 400 mg (Site 2, Lot B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: rTMS and Multi-Modality Aphasia Therapy for Post-Stroke Aphasia
Status: COMPLETED
Conditions: Stroke|Aphasia, Non-fluent
Interventions: DEVICE: 1Hz inhibitory rTMS|BEHAVIORAL: Multi-Modality Aphasia Therapy (M-MAT)|DEVICE: 1Hz sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Visceral Adiposity Measurement and Observation Study
Status: COMPLETED
Conditions: HIV|HIV-Infections|HIV-1-infection|HIV I Infection|HIV Lipodystrophy|HIV Infection Primary|HIV-Associated Lipodystrophy|HIV Disease Progression|Lipohypertrophy|Liver Diseases|NAFLD|NASH|Liver Fibrosis|Hepatic Fibrosis|Waist Circumference|BMI|Ectopic Fat|Liver Fat|Hepatic Steatosis
Interventions: DIAGNOSTIC_TEST: Diagnostic Test|DRUG: HIV Anti-retroviral Background Therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Atropine Therapeutic Effect on Myopic Progression
Status: RECRUITING
Conditions: Myopia|Children
Interventions: DRUG: Atropine Sulfate 01|DRUG: Atropine Sulfate 02|DRUG: Atropine Sulfate 03|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Drug Interaction Study of Dapagliflozin and Glimepiride or Sitagliptin in Healthy Subjects
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Dapagliflozin|DRUG: Glimepiride|DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Vaccine Therapy in Treating Patients With Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: ALVAC-hB7.1|BIOLOGICAL: canarypox-hIL-12 melanoma vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Acute Renal Failure After Cardiac Surgery in High Risk Patients Using Sodium Bicarbonate Therapy
Status: UNKNOWN
Conditions: Kidney Failure, Acute
Interventions: DRUG: Sodium bicarbonate|DRUG: Sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Randomized Controlled Trial of a Self-help Book for Insomnia in Patients With Co-morbid OSA and Insomnia
Status: COMPLETED
Conditions: Sleep Apnea|Insomnia
Interventions: BEHAVIORAL: Self-help book for insomnia|BEHAVIORAL: Sleep hygiene advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The (Flip and Fix) Internal Limiting Flap Technique Versus the Classic Temporal Flap for Macular Hole Repair
Status: COMPLETED
Conditions: Hacular Hole Repair
Interventions: PROCEDURE: Vitrectomy with ILM flap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Of Inotuzumab Ozogamicin Plus Rituximab For Relapsed/Refractory Aggressive Non-Hodgkin Lymphoma Patients Who Are Not Candidates For Intensive High-Dose Chemotherapy
Status: TERMINATED
Conditions: Lymphoma, Non-Hodgkin
Interventions: DRUG: Inotuzumab ozogamicin|DRUG: Rituximab|DRUG: rituximab + gemcitabine|DRUG: rituximab +bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Trans Fatty Acids From Ruminant Sources on Risk Factors for Cardiovascular Disease
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: OTHER: PHVO|OTHER: CLA|OTHER: VA|OTHER: base
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Effect of Physiotherapeutic Interventions on Quality of Life in Patients With Chronic Low Back Pain. (Study 1)
Status: COMPLETED
Conditions: Physical Therapy|Chronic Low Back Pain|Quality of Life|Range of Motion|Pain Intensity
Interventions: OTHER: Physioterapy intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Corticotrophin-releasing Hormone (CRH) on Esophageal Sensitivity in Healthy Volunteers
Status: COMPLETED
Conditions: Sensitivity (Hyper); Gastrointestinal
Interventions: DRUG: CRH|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Depot Medroxyprogesterone Acetate as Emergency Contraception
Status: COMPLETED
Conditions: Emergency Contraception|Contraception
Interventions: DRUG: Depot-Medroxyprogestereone Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study in Healthy People to Test How Well Different Doses of BI 3000202 Are Tolerated and How They Affect the Way the Body Handles Midazolam
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DRUG: BI 3000202|DRUG: Placebo|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Atezolizumab With Dendritic Cell Vaccine in Patients With Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Extensive-stage Small Cell Lung Cancer
Interventions: DRUG: Atezolizumab 1200 mg in 20 ML Injection|BIOLOGICAL: ADC Vaccine|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Surgical Approaches In Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Minimally invasive total knee replacement|PROCEDURE: Standard approach total knee replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: L Reuteri for the Prevention of Nosocomial Diarrhea
Status: COMPLETED
Conditions: Nosocomial Infection|Diarrhea|Gastroenteritis
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri (DSM 17938)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessing Endoloop-assisted Polypectomy in Patients With Antiplatelet Therapy
Status: COMPLETED
Conditions: Colorectal Polyp
Interventions: PROCEDURE: Endoloop-assisted "ligate and let go" colorectal polypectomy|PROCEDURE: Endoloop-assisted snare colorectal polypectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of a High Intensity Physical Activity Intervention on a Selection of Health Related Outcomes: An Ecological Approach
Status: COMPLETED
Conditions: To Assess the Impact of the HIT Intervention on Physiological Responses|To Assess the Role of a Secondary High School as a Setting for Promoting Healthy Eating and PA Behaviours|To Determine the Associations Between CVD Risk Factors at Baseline in 15 - 18 Year Old Youth
Interventions: BEHAVIORAL: High Intensity Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Study of Thyrotropin-Releasing Hormone in Normal Volunteers and in Patients With Thyroid or Pituitary Abnormalities
Status: COMPLETED
Conditions: Healthy|Pituitary Disease|Thyroid Disease
Interventions: DRUG: TRH (Thyrotropin Releasing Hormone)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 2 Trial of SCO-101 in Combination With FOLFIRI for Patients With Metastatic Colorectal Cancer (mCRC) With Acquired Resistance to FOLFIRI
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: FOLFIRI Protocol|DRUG: SCO-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Hydroquinone Versus Miconazol in Melasma
Status: UNKNOWN
Conditions: Melasma
Interventions: DRUG: Miconazole|DRUG: Hydroquinone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Administration of Neuropeptide Y in Healthy Male Volunteers
Status: COMPLETED
Conditions: Mood Disorder|Anxiety Disorders
Interventions: DRUG: Low dose NPY|DRUG: High dose NPY|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Correlation of Ultrasonography Indices of Venous Congestion With Intra-abdominal Pressure in ICU Patients.
Status: NOT_YET_RECRUITING
Conditions: Intra-Abdominal Hypertension|Venous Congestion
Interventions: DIAGNOSTIC_TEST: Abdominal ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cormet Large Diameter Metal on Metal (LDMOM) Total Hip System (G030265)
Status: TERMINATED
Conditions: Osteoarthritis|Rheumatoid Arthritis|Avascular Necrosis
Interventions: DEVICE: Large Diameter Metal on Metal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Bevacizumab in Myelodysplastic Syndromes (Int-1, Int-2 and High Risk According to International Prognostic Scoring System (IPSS)) With Excess of Marrow Blasts
Status: TERMINATED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: BEVACIZUMAB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Vector Vaccine GamCovidVac-M (Altered Antigenic Composition)
Status: NOT_YET_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: GamCovidVac-M vector vaccine for the prevention of COVID-19 with altered antigenic composition
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Gastroesophageal Reflux and Aspiration on Airway Inflammation and Microbiome in Children With Chronic Cough
Status: COMPLETED
Conditions: Chronic Cough (CC)|Gastroesophageal Reflux (GER)
Interventions: PROCEDURE: Esophago-gastro-duodenoscopy (EGD) with biopsy|PROCEDURE: Esophageal Impedance Monitoring (EIM)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dexmedetomidine Reduce Postoperative Pain of C-section
Status: RECRUITING
Conditions: Pain, Postoperative
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Augment® Injectable Bone Graft Compared to Autologous Bone Graft as a Bone Regeneration Device in Hindfoot Fusions
Status: COMPLETED
Conditions: Degenerative Joint Disease|Congenital Deformity|Arthritis|Osteoarthritis|Rheumatoid Arthritis
Interventions: DEVICE: Augment® Injectable Bone Graft|PROCEDURE: Autologous bone graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mannitol Dose Response Study in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: mannitol|DRUG: mannitol|DRUG: mannitol|DRUG: mannitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation for Primary Clostridium Difficile Diarrhea
Status: WITHDRAWN
Conditions: Clostridium Difficile
Interventions: BIOLOGICAL: Fecal Microbiota Transplantation|DRUG: Vancomycin|BIOLOGICAL: Fecal Microbiota Transplantation Placebo|DRUG: Vancomycin Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Study of AURN001 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction (ABA-1)
Status: ACTIVE_NOT_RECRUITING
Conditions: Corneal Edema|Corneal Endothelial Dysfunction
Interventions: COMBINATION_PRODUCT: AURN001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Elective Level Ib Irradiation in Nasopharyngeal Carcinoma Patients Based on the International Guidelines
Status: NOT_YET_RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: RADIATION: level Ib-covering IMRT|RADIATION: level Ib-sparing IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Pembrolizumab in N2 Positive Non-small Cell Lung Cancer Patients
Status: UNKNOWN
Conditions: Stage IIIA Non-small Cell Lung Cancer
Interventions: DRUG: Pembrolizumab|PROCEDURE: Curative resection|PROCEDURE: Neoadjuvant concurrent chemoradiotherapy|DRUG: Cisplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyaluronic Acid Effect on Xenogenic Bone Healing
Status: UNKNOWN
Conditions: Bone Resorption|Tooth Loss
Interventions: PROCEDURE: Ridge preservation: Tooth extration and immediat bone grafting in the socket
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitrectomy With Planned Foveal Detachment for Refractory DME With or Without Vitreo-macular Interface Abnormality
Status: UNKNOWN
Conditions: Chronic Edema of the Macula
Interventions: PROCEDURE: vitrectomy with planned foveal detachment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sterilised, Porcine Placental Tissue in the Treatment of Chronic Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: InnovaMatrix AC porcine placental ECM therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Idarubicin Dose Intensification to Treat Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: Idarubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Lucinactant for Inhalation in Preterm Neonates 26 to 32 Weeks Gestational Age
Status: TERMINATED
Conditions: Respiratory Distress Syndrome, Newborn
Interventions: COMBINATION_PRODUCT: Lucinactant for Inhalation|OTHER: nCPAP Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TranSfUsion of coNvalescent plAsma for the Early Treatment of pneuMonIa in COVID-19 Patients
Status: COMPLETED
Conditions: Covid19|Coronavirus Infection|Pneumonia, Viral
Interventions: BIOLOGICAL: Convalescent plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nelfinavir, Radiation Therapy, Cisplatin, and Etoposide in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: etoposide|DRUG: nelfinavir mesylate|GENETIC: protein expression analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|PROCEDURE: biopsy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Amyloid PET in Cerebral Amyloid Angiopathy
Status: COMPLETED
Conditions: Cerebral Amyloid Angiopathy|Intracranial Hemorrhages|Alzheimer Disease
Interventions: DRUG: amyloid PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: CD3/CD19 Depleted or CD3 Depleted/CD56 Selected Haploid Donor Natural Killer Cell Treatment in Older AML in First Complete Remission
Status: WITHDRAWN
Conditions: Acute Myelogenous Leukemia
Interventions: BIOLOGICAL: CD3-/CD19- natural killer cells|BIOLOGICAL: CD3-CD56+ natural killer cells|DEVICE: CliniMACS® CD3 and CD19 Reagent System|DEVICE: CliniMACS® CD56 Reagent System|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of a Self-management Intervention on Low Literacy Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: Self-Management Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Developing a Model to Predict Inpatient Hypoglycemic Episodes
Status: WITHDRAWN
Conditions: Hypoglycemic Events|Hyperglycemic Therapy
Interventions: DIAGNOSTIC_TEST: EndoTool|OTHER: glucose management team|OTHER: standard of care glucose management
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Brock Exercise And Supplement Trials
Status: COMPLETED
Conditions: Untrained|Healthy
Interventions: BEHAVIORAL: Resistance and Plyometric Exercise|DIETARY_SUPPLEMENT: Greek Yogurt (0% Plain)|DIETARY_SUPPLEMENT: Placebo - Study Designed Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab and Standard Treatment With Chemo- and Immunotherapy as First Line Treatment for HER2 Positive Esophageal Squamous Cell Carcinoma Patients
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma|HER-2 Protein Overexpression|HER-2 Gene Amplification
Interventions: DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Oral Ibrexafungerp (SCY-078) vs. Oral Fluconazole in Subjects With Vulvovaginal Candidiasis
Status: COMPLETED
Conditions: Vulvovaginal Candidiasis
Interventions: DRUG: SCY-078|DRUG: Fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study of Autologous Fat Grafting for Breast Augmentation
Status: COMPLETED
Conditions: Breast Augmentation|Fat Grafting
Interventions: PROCEDURE: breast implants|PROCEDURE: Liposuction, fat grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: L-Carnitine and Clomiphene Citrate for Induction of Ovulation in Women With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: oral clomiphene citrate|DRUG: oral carnitine supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Immunoadsorption, Dexamethasone Pulse Therapy and Rituximab for Pemphigus
Status: COMPLETED
Conditions: Pemphigus
Interventions: DRUG: Combination of Protein A Immunoadsorption, Rituximab, Dexamethasone plus Azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Nitrates for Heart Failure (HF)
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure|Hypertension, Pulmonary
Interventions: DIETARY_SUPPLEMENT: Beetroot Juice (BRJ)|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Etoricoxib on Peripheral Hyperalgesia
Status: TERMINATED
Conditions: Causalgia|Polyneuropathy|Postherpetic Neuralgia|Peripheral Nerve Injury|Radiculopathy
Interventions: DRUG: Etoricoxib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: INSTEAD Trial: INvestigation of STEnt Grafts in Patients With Type B Aortic Dissection
Status: COMPLETED
Conditions: Aortic Diseases
Interventions: DEVICE: Medtronic Talent Stent-Graft-System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Comparative of the Association Beclomethasone Clotrimzaol + Gentamicin in Patients With Acne Contaminated
Status: SUSPENDED
Conditions: Folliculitis
Interventions: DRUG: Clotrimazole + Gentamicin + Beclomethasone|DRUG: Clotrimazole + Gentamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Clinical Trial of OXi4503 for Relapsed and Refractory AML and MDS
Status: TERMINATED
Conditions: Leukemia, Myelogenous, Acute|Myelodysplastic Syndromes
Interventions: DRUG: OXi4503
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase IIa Multi-Center Study of 18F-FDG PET, Safety, and Tolerability of AZD0530 in Mild Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: AZD0530 100mg daily|DRUG: AZD0530 125mg daily|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CNP-201 in Subjects With Peanut Allergy
Status: TERMINATED
Conditions: Peanut Allergy
Interventions: DRUG: CNP-201|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COLDFIRE-III Trial: Efficacy of Irreversible Electroporation and Stereotactic Body Radiotherapy for Perivascular and Peribiliary Colorectal Liver Metastases
Status: RECRUITING
Conditions: Colorectal Cancer|Liver Metastases|Liver Metastasis Colon Cancer|Unresectable Solid Tumor
Interventions: PROCEDURE: Irreversible electroporation|RADIATION: Stereotactic body radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT