pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Adjuvant Therapy With Pergolide in Treating Cognitive Deficits in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Pergolide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Dexamethasone on the Duration of Sciatic Nerve Blocks
Status: TERMINATED
Conditions: Total Knee Arthroplasty
Interventions: DRUG: Ropivacaine|DRUG: Dexamethasone|DRUG: Dexamethasone|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of Traditional Directly Observed Therapy (DOT) and Electronic DOT for TB Treatment
Status: COMPLETED
Conditions: Tuberculosis|Drug-resistant Tuberculosis|Adherence, Medication|Adherence, Patient
Interventions: OTHER: Electronic DOT|OTHER: In-person DOT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Stretch-shortening Cycle Exercises Postural Control in Down Syndrome
Status: COMPLETED
Conditions: Down Syndrome
Interventions: OTHER: Standard physical therapy|OTHER: trampoline-based stretch-shortening cycle exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brain Regions and Functional Neuronal Network Characteristics of Dexmedetomidine Analgesia
Status: UNKNOWN
Conditions: Epilepsy|Radiofrequency Ablation
Interventions: DRUG: Dexmedetomidine Injectable Solution|DRUG: Sodium Chloride 0.9% Inj
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bioequivalence Study of Ivermectin 1% Cream and Soolantra (Ivermectin) 10 mg/g Cream
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: Ivermectin cream|DRUG: Soolantra ® (Ivermectin) cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Using Non-Fluoroscopic Imaging Devices to Decrease Radiation Exposure During Ablation of Supraventricular Tachycardia
Status: COMPLETED
Conditions: Supraventricular Tachycardia
Interventions: DEVICE: Intracardiac echocardiography and 3D navigational system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tusamitamab Ravtansine Monotherapy and in Combination in Patients With CEACAM5-positive Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer Metastatic|Pancreatic Carcinoma Metastatic
Interventions: DRUG: tusamitamab ravtansine|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial of Three Antibiotic Regimens for First Trimester Abortions
Status: COMPLETED
Conditions: First Trimester Abortion
Interventions: DRUG: Azithromycin|DRUG: Doxycycline|DRUG: Metronidazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Dose Finding Study to Determine if BEZ235 Alone or in Combination With RAD001 Decreases the Incidence of Respiratory Tract Infections in the Elderly
Status: ACTIVE_NOT_RECRUITING
Conditions: Respiratory Tract Infections
Interventions: OTHER: Placebo|DRUG: BEZ235|DRUG: BEZ235 plus everolimus (RAD001)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of an Antioxidant-rich Multivitamin Supplement in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DIETARY_SUPPLEMENT: AquADEK
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydrogen-rich Water for Molecular and Phenotypic Biomarkers of Aging
Status: COMPLETED
Conditions: Aging
Interventions: DIETARY_SUPPLEMENT: Hydrogen-rich water|OTHER: Control Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Preventative Omalizumab or Step-up Therapy for Severe Fall Exacerbations
Status: COMPLETED
Conditions: Asthma
Interventions: BIOLOGICAL: Omalizumab|DRUG: Inhaled Corticosteroid Boost Therapy (ICS)|BIOLOGICAL: Placebo omalizumab|BIOLOGICAL: Placebo fluticasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of RT-CGM on Glycemia and QoL in Patients With T1DM and IHA
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus|Hypoglycemia Unawareness
Interventions: DEVICE: Real-time continuous glucose monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Ataciguat in Patients With Moderate Calcific Aortic Valve Stenosis
Status: COMPLETED
Conditions: Aortic Valve Stenosis
Interventions: DRUG: Ataciguat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Comparison Chocolate With and Without High Cocoa Solids in Patients With Type 2 Diabetes in a Randomised Clinical Trial
Status: COMPLETED
Conditions: Diabetes Type 2
Interventions: OTHER: Cocoa Polyphenols
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Intravenous Mircera in Dialysis Patients With Chronic Renal Disease and Anemia.
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: methoxy polyethylene glycol-epoetin beta [Mircera]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted Biopsy of Carbon Nanoparticles Labelled Axillary Node for cN+ Breast Cancer
Status: COMPLETED
Conditions: Location and Biopsy of Axillary Lymph Nodes
Interventions: DRUG: Carbon nanoparticles suspension injection will be injected into or around the cortex of the clinically assessed positive lymph nodes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Canadian Prevention of Renal and Cardiovascular Endpoints Trial
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: OTHER: Combined CKD and CVD Prevention|OTHER: Cardiovascular Disease prevention|OTHER: Treatment of Chronic Kidney Disease complications|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Enteral Glutamine in Reducing Bloodstream Infections in Short Bowel Syndrome Infants
Status: COMPLETED
Conditions: Bloodstream Infections|Short Bowel Syndrome|Development|Nutrition|Biological Markers
Interventions: DRUG: Glutamine|DIETARY_SUPPLEMENT: L-alanine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Obesity-related Health Benefits of Apples
Status: COMPLETED
Conditions: Obesity, Abdominal|Hyperlipidemias|Inflammation|Dysbiosis
Interventions: OTHER: Apples
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Anthropometric and Physical Fitness Differences Among Turkish Adolescents and Adults Handball Players
Status: COMPLETED
Conditions: Athletic Performance|Physical Fitness|Handball Players|Cross-sectional Studies
Interventions: OTHER: LSST test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Efficacy of EMLA Cream vs. Synera Patch for Pain Reduction During Venipuncture in Children
Status: COMPLETED
Conditions: Pain|Needle Phobia
Interventions: DRUG: EMLA Cream|COMBINATION_PRODUCT: Synera Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Vitamin D3 on Postoperative Pain in Patients Undergoing Craniotomy
Status: COMPLETED
Conditions: Brain Neoplasms
Interventions: DRUG: vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study for Fixed Dose Combination Zemimet® SR Tab. 50/1000 and Coadministration of Gemigliptin 50 mg and Metformin 1000 mg.
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Gemigliptin tartrate sesquihydrate and metformin|DRUG: gemigliptin 50 mg and metformin hydrochloride 1000 mg prolonged release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internal Iliac Artery Ligation During Management of Placenta Accreta Spectrum
Status: COMPLETED
Conditions: Placenta Accreta
Interventions: PROCEDURE: Internal iliac artery ligation with cervicoisthmic compression suture|PROCEDURE: Cervicoisthmic compression suture without Internal iliac artery ligation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Naldemedine (S-297995) for the Treatment of Opioid-Induced Constipation in Adults With Non-Malignant Chronic Pain Receiving Opioid Therapy
Status: COMPLETED
Conditions: Opioid-induced Constipation
Interventions: DRUG: Placebo|DRUG: Naldemedine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Functional Performance in Individuals With Parkinson's Disease Following 2-month Physiotherapy Intervention
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: Comprehensive physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Integrative Alcohol and Risky Sex Feedback for College Students
Status: NOT_YET_RECRUITING
Conditions: Alcohol Drinking in College|Sexual Behavior
Interventions: BEHAVIORAL: Cross-tailored Dynamic Feedback|BEHAVIORAL: Personalized Feedback Intervention|BEHAVIORAL: Dynamic Feedback on General Health Behaviors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Multiple Dose Pharmacokinetics Depot Buprenorphine in Opioid-Dependent Subjects
Status: COMPLETED
Conditions: Opioid Related Disorder
Interventions: DRUG: RBP-6000|DRUG: Subutex
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Morphine Versus Methadone for Opiate Exposed Infants With Neonatal Abstinence Syndrome
Status: COMPLETED
Conditions: Neonatal Abstinence Syndrome
Interventions: DRUG: Morphine|DRUG: Methadone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementing Pathways to Improve Pediatric Asthma Care
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: PIPA Intervention Bundle 1|BEHAVIORAL: PIPA Intervention Bundle 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Open Versus Close Chain Exercise Effects With Lifestyle Modification and Education in Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: close kinetic chain exercises|OTHER: open kinetic chain exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of PARO to Decrease Agitation in Persons With Dementia and/or Delirium
Status: COMPLETED
Conditions: Dementia|Delirium
Interventions: OTHER: PARO Robotic Seal Intervention|OTHER: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy Confirmation Study of CDP870 in Early Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Placebo|DRUG: CZP|DRUG: methotrexate (MTX)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Research for Pathophysiology of Cancer Related Fatigue (CRF) and Chronic Fatigue (CFS/ME)
Status: RECRUITING
Conditions: Cancer Related Fatigue|Fatigue Syndrome, Chronic
Interventions: DIETARY_SUPPLEMENT: Probiotics|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Grazoprevir (+) Uprifosbuvir (+) Ruzasvir (MK-3682B) (MK-5172 + MK-3682 + MK-8408) Fixed Dose Combination in Chronic HCV Participants Failing Prior Antiviral Treatment (MK-3682-021)
Status: TERMINATED
Conditions: Hepatitis|Hepatitis C|Digestive System Diseases|Flaviviridae Infections|Hepatitis, Viral, Human|Liver Diseases|RNA Virus Infections|Virus Diseases
Interventions: DRUG: MK-3682B|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serial FES PET/CT to Measure Hormone Expression in Patients Undergoing Endocrine Targeted Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Estrogen Receptor Positive|Primary or Recurrent Breast Carcinoma|Stage IV Breast Cancer AJCC v6 and v7
Interventions: DRUG: F-18 16 Alpha-Fluoroestradiol|PROCEDURE: Positron Emission Tomography|PROCEDURE: Computed Tomography|DRUG: Fludeoxyglucose F-18|PROCEDURE: Positron Emission Tomography|PROCEDURE: Computed Tomography|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Percutaneous Endoluminal Benign Biliary Laser
Status: RECRUITING
Conditions: Benign Biliary Strictures With Current or Prior Biliary Obstruction
Interventions: PROCEDURE: Percutaneous transhepatic cholangioscopic (PTCS) laser incision
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of the Implementation of BIS on the Incidence of Postoperative Delirium
Status: UNKNOWN
Conditions: Postoperative Delirium
Interventions: DEVICE: BIS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Reducing Donor Specific Antibody (DSA) Strength in Maintenance Kidney Transplant Recipients (DSA Study)
Status: COMPLETED
Conditions: Transplant; Failure, Kidney
Interventions: DRUG: Myfortic Escalation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Efficacy and Safety of CKD-506 in Adult Subjects With Moderate-to-Severe Rheumatoid Arthritis and Inadequate Response to Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: CKD-506|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Short Course Radiation Therapy in Palliative Treatment of Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Cancer|Radiotherapy|Palliative Care
Interventions: RADIATION: standard treatment|RADIATION: short course treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted Optical Biopsy for Local Rectal Scars in Rectal Cancer Patients After Neoadjuvant Chemoradiotherapy
Status: RECRUITING
Conditions: Rectal Cancer
Interventions: DEVICE: Probe-based confocal laser endomicroscopy targeted optical biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Effects of Calcitriol's in the Neurological Symptoms of Friedreich's Ataxia Patients
Status: COMPLETED
Conditions: Friedreich Ataxia
Interventions: DRUG: Calcitriol|OTHER: Blood analysis for frataxin's level measurement|DIAGNOSTIC_TEST: Blood analysis for hypercalcemia's control
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Morning vs. Evening Vaccination on Hypoxia and Bradycardia of Preterm Infants: a Randomised Controled Trial
Status: COMPLETED
Conditions: Premature Birth|Intermittent Hypoxiema
Interventions: BIOLOGICAL: Infanrix + Prevenar 13
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega-3 and Blueberry Supplementation in Age-Related Cognitive Decline
Status: COMPLETED
Conditions: Age-related Memory Disorders|Mood Disorders
Interventions: DIETARY_SUPPLEMENT: Omega-3 fatty acid|DIETARY_SUPPLEMENT: Blueberry powder|OTHER: Placebo oil|OTHER: Placebo powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized Neoantigen Vaccine in Combination With Durvalumab (MEDI4736) in Extensive Stage Small Cell Lung Cancer
Status: RECRUITING
Conditions: Extensive-stage Small Cell Lung Cancer
Interventions: BIOLOGICAL: Neoantigen DNA vaccine|DRUG: Durvalumab|DEVICE: TDS-IM v2.0 Device|PROCEDURE: Peripheral blood draws
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodal Prehabilitation in Colorectal Cancer Patients
Status: RECRUITING
Conditions: Colon Cancer|Prehabilitation
Interventions: OTHER: Trimodal prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate)
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: DRUG: Alcohol|DRUG: Placebos|DRUG: Duloxetine|DRUG: Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Endocrine Therapy in Treating Patients With HER2 Negative, Low Risk Breast Cancer
Status: WITHDRAWN
Conditions: HER2/Neu Negative|Invasive Breast Carcinoma|Postmenopausal|Stage 0 Breast Cancer|Stage IA Breast Cancer
Interventions: DRUG: Anastrozole|DRUG: Exemestane|OTHER: Laboratory Biomarker Analysis|DRUG: Letrozole|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|DRUG: Tamoxifen Citrate|DRUG: Toremifene Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Pharmacotherapy in Counteracting Weight Regain in Adolescents With Severe Obesity
Status: RECRUITING
Conditions: Obesity
Interventions: DRUG: Phentermine-Topiramate|DIETARY_SUPPLEMENT: Meal Replacement Therapy|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Activity of BIVV009 in Healthy Volunteers and Patients With Complement Mediated Disorders
Status: COMPLETED
Conditions: Bullous Pemphigoid (BP)|Cold Agglutinin Disease (CAD)|Warm Autoimmune Hemolytic Anemia (WAIHA)|End-stage Renal Disease (ESRD)
Interventions: DRUG: BIV009|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Water and Salt Intake on Copeptin Levels During Moderate Alcohol Consumption
Status: COMPLETED
Conditions: Alcohol Drinking
Interventions: OTHER: Beer 5%o|OTHER: Beer 8.5%o and water|OTHER: Beer 8.5%o and stock|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Icotinib as Neoadjuvant and Adjuvant Therapy in EGFR-mutant Stage IIIB or Oligometastasis Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: EGF-R Positive Non-Small Cell Lung Cancer
Interventions: DRUG: Icotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tramadol Versus Celecoxib for Reducing Pain in Outpatient Hysteroscopy
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Tramadol|DRUG: Celecoxib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Control of Steatorrhea in Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency
Status: COMPLETED
Conditions: Exocrine Pancreatic Insufficiency|Cystic Fibrosis
Interventions: DRUG: Panzytrat® 25,000|DRUG: Kreon® 25,000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating [177Lu]Lu-PSMA-617 vs. a Change of Androgen Receptor-directed Therapy in Taxane Treatment Naive Chinese Male Patients With Progressive Metastatic Castrate Resistant Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Interventions: DRUG: [177Lu]Lu-PSMA-617|DRUG: ARDT|DRUG: [68Ga]Ga-PSMA-11|OTHER: Best supportive care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on the Anti-Wrinkle Efficacy Assessment and Safety Evaluation of the Cluster of Autologous Dermal Fibroblast on Bilateral Crow's Feet
Status: UNKNOWN
Conditions: Crow's Feet
Interventions: BIOLOGICAL: Clusters of Autologous Dermal Fibroblasts|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Brain Stimulation on Cognition, Oscillations and GABA Levels in Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia
Interventions: DEVICE: Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 2a EBA Trial of AZD5847
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: AZD5847|DRUG: Ethambutol, isoniazid, pyrazinamide, rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure
Status: COMPLETED
Conditions: Heart Failure|Iron Deficiency Anemia
Interventions: DRUG: Sodium ferric gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lesser Tuberosity Osteotomy for Subscapularis Repair
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: PROCEDURE: TSA with tenotomy technique|PROCEDURE: TSA with lesser tuberosity osteotomy technique|DEVICE: Shoulder prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Oxaliplatin/Irinotecan/Bevacizumab Followed by Docetaxel/Bevacizumab in Inoperable Locally Advanced or Metastatic Gastric Cancer Patients
Status: COMPLETED
Conditions: Gastric Cancer|Unresectable
Interventions: DRUG: Oxaliplatin, Irinotecan, Bevacizumab, Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantification of Nerve Stiffness in Neuropathies
Status: UNKNOWN
Conditions: Chronic Inflammatory Demyelinating Polyneuropathy|Charcot-Marie-Tooth Disease, Type IA|Anti-MAG Neuropathy
Interventions: OTHER: elastography measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treosulfan and Fludarabine Phosphate Before Donor Stem Cell Transplant in Treating Patients With Nonmalignant Inherited Disorders
Status: COMPLETED
Conditions: Non-Neoplastic Hematologic and Lymphocytic Disorder
Interventions: PROCEDURE: Allogeneic Bone Marrow Transplantation|BIOLOGICAL: Anti-Thymocyte Globulin|DRUG: Cyclosporine|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|DRUG: Methotrexate|DRUG: Mycophenolate Mofetil|PROCEDURE: Peripheral Blood Stem Cell Transplantation|DRUG: Tacrolimus|RADIATION: Total-Body Irradiation|DRUG: Treosulfan|PROCEDURE: Umbilical Cord Blood Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: National Cohort on Congenital Defects of the Eye
Status: RECRUITING
Conditions: Anophthalmia|Microphthalmia|Aniridia|Anterior Segment Dysgenesis 6, Peters Anomaly Subtype|Anterior Segment Dysgenesis 3, Rieger Subtype
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study in Healthy Men and Women to Test Which Effects Memantine and BI 425809 Have on Each Other
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 425809|DRUG: Memantine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of RO5429083 in Patients With Metastatic and/or Locally Advanced, CD44-Expressing, Malignant Solid Tumors
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: RO5429083|DRUG: RO5429083
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of an Intraoperative Periradicular Application of Platelet Rich Fibrin (PRF) on the Intensity of Residual Post-surgical Neuropathic Pain After a Surgery for Disc Herniation
Status: RECRUITING
Conditions: Neuropathic Pain|Chronic Postsurgical Pain
Interventions: BIOLOGICAL: Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Timing of Planned Caesarean Section and Morbidity of the Newborn
Status: COMPLETED
Conditions: Respiratory Disorders|Intensive Care, Neonatal
Interventions: PROCEDURE: Elective caesarean section|PROCEDURE: Elective caesarean section
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multicentric Evaluation of Two Telematics Systems in Type 2 Diabetic Patients in Failure of Oral Treatment and Having to Start Treatment by Basal Insulin
Status: COMPLETED
Conditions: TYPE 2 DIABETES
Interventions: DEVICE: placebo|DEVICE: IVS|DEVICE: PDAphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Transcranial Direct Current Stimulation for Post-stroke Fatigue
Status: RECRUITING
Conditions: Fatigue|Stroke Rehabilitaion
Interventions: DEVICE: Real Soterix Mini-CT tDCS stimulator|DEVICE: Sham Soterix Mini-CT tDCS stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tepotinib Plus Osimertinib in Osimertinib Relapsed MET Amplified NSCLC (INSIGHT 2)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Tepotinib|DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strontium Compared With Radiation Therapy in Treating Patients With Hormone-Refractory Prostate Cancer With Painful Bone Metastases
Status: COMPLETED
Conditions: Metastatic Cancer|Prostate Cancer
Interventions: RADIATION: strontium chloride Sr 89
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and Pharmacodynamic Interactions Between the Cholesterol-lowering Ezetimibe and the Non-nucleoside Reverse Transcriptase Inhibitor Efavirenz During Chronic Treatment in Healthy Volunteers With Reference to Intestinal Expression of CYP3A4, UGT1A1, ABCB1 and ABCC2
Status: COMPLETED
Conditions: Pharmacokinetics|Drug Interactions|Pharmacodynamics|Intestinal Transporter Expression
Interventions: DRUG: Ezetrol (ezetimibe) multiple dose|DRUG: Ezetrol (ezetimibe) multiple dose and Sustiva (efavirenz) single dose|DRUG: Ezetrol (ezetimibe) and Sustiva (efavirenz) multiple dose|DRUG: Sustiva (efavirenz) single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Concurrent Dabrafenib + Trametinib With Sterotactic Radiation in BRAF Mutation-Positive Malignant Melanoma and Brain Metastases
Status: TERMINATED
Conditions: Melanoma|Brain Metastases
Interventions: DRUG: Dabrafenib|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anecortave Acetate in Patients With Open-angle Glaucoma
Status: COMPLETED
Conditions: Open-angle Glaucoma
Interventions: DRUG: Anecortave Acetate Sterile Suspension, 6 mg/mL|DRUG: Anecortave Acetate Sterile Suspension, 30 mg/mL|DRUG: Anecortave Acetate Sterile Suspension, 60 mg/mL|OTHER: Anecortave Acetate Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extension of Study ZPV-200
Status: COMPLETED
Conditions: Uterine Fibroids
Interventions: DRUG: telepristone acetate 12 mg|DRUG: telepristone acetate 3 mg|DRUG: telepristone acetate 6 mg|DRUG: telepristone acetate 12 mg|DRUG: telepristone acetate 24 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Mini-PCNLversus RIRS for the Management of Upper Urinary Tract Calculus (1-2.5 cm)
Status: COMPLETED
Conditions: Stone, Kidney
Interventions: PROCEDURE: mini-PCNL procedure|PROCEDURE: RIRS procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-Center, Pediatric, Open-Label, Preference Study of Desloratadine 2.5 mg Reditab (SCH34117) and Zyrtec ® 5.0 mg Chewable Tablet Medications (Study P04573) (Completed)
Status: COMPLETED
Conditions: Allergies
Interventions: DRUG: Desloratadine|DRUG: Zyrtec® (cetirizine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The LINFU® U.S. Registry for the in the General Population Without Risk Factors
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Cancer|Pancreatic Ductal Adenocarcinoma|Pancreatic Dysplasia
Interventions: DIAGNOSTIC_TEST: LINFU®
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Talar Mobilization With Movement Versus Acupuncture on Knee Pain and Function in the Postmenopausal Women
Status: COMPLETED
Conditions: Talar Mobilization Acupuncture
Interventions: OTHER: Mobilization wih movement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab (MK-3475) Monotherapy for Metastatic Triple-Negative Breast Cancer (MK-3475-086/KEYNOTE-086)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Keto Diet and PET Imaging in Anorexia Nervosa
Status: NOT_YET_RECRUITING
Conditions: Anorexia Nervosa
Interventions: DIETARY_SUPPLEMENT: Therapeutic Ketogenic Diet (TKD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Cefecin Tab. in Patients With Acute Sinusitis
Status: TERMINATED
Conditions: Acute Sinusitis
Interventions: DRUG: Cefecin Tab.|DRUG: Omnicef Cap.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pendulum D2D Glucose Control for Adults With Type 2 Diabetes
Status: WITHDRAWN
Conditions: Type2 Diabetes|Gastrointestinal Symptoms
Interventions: DIETARY_SUPPLEMENT: Pendulum Glucose Control formulation for T2D
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Micronutrient Supplemented Probiotic Yogurt for HIV/AIDS and Other Immunodeficiencies
Status: COMPLETED
Conditions: HIV Infections|Cancer, Second Primary
Interventions: DIETARY_SUPPLEMENT: Probiotic Yogurt B: with various micronutrients|DIETARY_SUPPLEMENT: Probiotic Yogurt A: Kaiser micronutrients|DIETARY_SUPPLEMENT: Probiotic yogurt C: with basic micronutrients|DIETARY_SUPPLEMENT: Probiotic Yogurt D: Placebo -- no added micronutrients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Training Given to Patients With COPD in Line With Pender's Health Promotion Model
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Self Efficacy
Interventions: BEHAVIORAL: Intervention group trained in line with the Health Promotion Model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cupping Therapy in Chronic Nonspecific Low Back Pain
Status: NOT_YET_RECRUITING
Conditions: Chronic Low-back Pain|Chronic Non-specific Low Back Pain|Low Back Pain|Cupping Therapy
Interventions: OTHER: True dry cupping therapy|OTHER: Sham cupping therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety of and Immune Response to a Dengue Virus Vaccine (rDEN3-3'Ddelta30) in Healthy Adults
Status: COMPLETED
Conditions: Dengue
Interventions: BIOLOGICAL: rDEN3-3'D4delta30|BIOLOGICAL: rDEN3-3'D4delta30|BIOLOGICAL: rDEN3-3'D4delta30
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma
Status: RECRUITING
Conditions: Sarcoma|HER-2 Protein Overexpression|Osteosarcoma|Rhabdomyosarcoma|Ewing Sarcoma|Synovial Sarcoma|Soft Tissue Sarcoma|Undifferentiated Sarcoma
Interventions: GENETIC: T cells or CAR T cells|DRUG: Pembrolizumab Injectable Product|DRUG: Nivolumab Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Dual TAP Block: Magnetic Resonance (MR) Evaluation of the Distribution of Local Anesthetic
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Bupivacaine|PROCEDURE: Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: [11C]Cimbi-36 Dosimetry
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: [11C]Cimbi-36|DRUG: [11C]Cimbi-36-5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparative Study of BAT1806 to RoActemra® in Rheumatoid Arthritis Patients With Inadequate Response to Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: BAT1806|DRUG: Actemra(EU-licensed)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exisulind and Intermittent Androgen Suppression (ADT) in Biochemical Relapsed Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Exisulind|DRUG: luteinizing hormone-releasing hormone (LHRH) agonist|DRUG: Antiandrogen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Comparison of PYY, Ghrelin, GLP1, Glucose Level, Level of Satiety, and Ad Libitum Intake in Obese and Non-Obese Patients After Breakfast With Balanced Macronutrient Composition
Status: COMPLETED
Conditions: PYY|Ghrelin|Appetite|Gut Hormones|Obesity|VAS of Satiety|VAS of Hunger|GLP - 1
Interventions: BEHAVIORAL: Diet with balance composition to know the effect of a meal to gut hormones in obese and non obese women
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Certican® (Everolimus) Against Cytomegalovirus Disease in Renal Transplant Patients
Status: UNKNOWN
Conditions: Cytomegalovirus Disease
Interventions: DRUG: Certican (everolimus) + valganciclovir|DRUG: Valganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of the Red Cell Distribution Width, NT-proBNP and cTnT in Acute Myocardial Infarction Patients
Status: NOT_YET_RECRUITING
Conditions: Myocardial Infarction
Interventions: DIAGNOSTIC_TEST: CBC|DIAGNOSTIC_TEST: (NT-proBNP)|DIAGNOSTIC_TEST: (cTnT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transperineal Laser Ablation for Percutaneous Treatment of Benign Prostatic Hyperplasia
Status: UNKNOWN
Conditions: BPH|Lower Urinary Tract Symptoms
Interventions: DEVICE: Transperineal Focal Laser Ablation (TPLA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eculizumab to Treat Thrombotic Microangiopathy/Atypical Hemolytic Uremic Syndrome -Associated Multiple Organ Dysfunction Syndrome in Hematopoietic Stem Cell Transplant Recipients
Status: COMPLETED
Conditions: Thrombotic Microangiopathies|Atypical Hemolytic Uremic Syndrome|Multiple Organ Dysfunction Syndrome
Interventions: DRUG: Eculizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Azidothymidine, With or Without Radiotherapy, for High Grade Lymphoma in AIDS-Risk Group Members
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin|HIV Infections
Interventions: DRUG: Bleomycin sulfate|DRUG: Vincristine sulfate|DRUG: Doxorubicin hydrochloride|DRUG: Cyclophosphamide|DRUG: Allopurinol|DRUG: Methotrexate|DRUG: Cytarabine|DRUG: Leucovorin calcium|DRUG: Zidovudine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Electrocardiogram-based Artificial Intelligence-assisted Detection of Heart Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation|Structural Heart Disease
Interventions: DEVICE: Zio Patch Monitor|DEVICE: Echocardiogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Acoustic Cueing During Slow-wave Sleep as a Measure to Improve Motor Rehabilitation Outcome in Stroke Patients
Status: UNKNOWN
Conditions: Stroke
Interventions: BEHAVIORAL: melody during motor training and slow wave sleep|BEHAVIORAL: melody only during motor training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: 3D Resin Printed Fracture Models for Anatomy Education
Status: RECRUITING
Conditions: Educational Problems|Anatomical Pathological Condition
Interventions: OTHER: Clinical Anatomical Education with Fractured Bone Models|OTHER: Clinical Anatomical Education with Standard Bone Models
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Interest in Clonidine in Association With Levobupivacaine Performing a Pudendal Block in Proctological Surgery.
Status: UNKNOWN
Conditions: Proctological Surgery
Interventions: DRUG: Clonidine|DRUG: Levobupivacaine|DRUG: NaCl 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low vs. Moderate to High Dose Vitamin D for Prevention of COVID-19
Status: ACTIVE_NOT_RECRUITING
Conditions: SARS-CoV-2 Infection
Interventions: DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Single-center Ambispective Observational Study on the Role of Magnetic Resonance Imaging (MRI) in the Evaluation of Patient Affected by Hepatic Metastases of Carcinoma of the Colorectal Cancer (CRC).
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: RADIATION: Hepatic MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Probiotics, Metformin & Their Combination Therapy in the Treatment of PCOS
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Probiotic Agent|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recurrent Abdominal Pain in Children
Status: COMPLETED
Conditions: Abdominal Pain|Irritable Bowel Syndrome
Interventions: BEHAVIORAL: Elimination Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Daratumumab, VELCADE (Bortezomib), Lenalidomide and Dexamethasone Compared to VELCADE, Lenalidomide and Dexamethasone in Subjects With Previously Untreated Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Daratumumab|DRUG: velcade|DRUG: Lenalidomide|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ranibizumab Injections to Treat Macular Telangiectasia With New Blood Vessel Growth
Status: COMPLETED
Conditions: Neovascularization
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Ulixertinib for Patients With Advanced Malignancies Harboring MEK or Atypical BRAF Alterations
Status: TERMINATED
Conditions: Advanced Solid Tumor|BRAF Gene Mutation|BRAF Gene Alteration|MEK Mutation|MEK Alteration|MAP2K1 Gene Mutation|MAP2K1 Gene Alteration|MAP2K2 Gene Mutation|MAP2K2 Gene Alteration
Interventions: DRUG: Ulixertinib|DRUG: Physician's Choice
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of 15 and 30 mg Doses of CVL-231 (Emraclidine) in Participants With Schizophrenia
Status: ACTIVE_NOT_RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: CVL-231 15 mg|DRUG: Required CVL-231 30 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study for the Detection of Duodenal Papilla Using Capsule Endoscopy and Comparison of Images With EUS/ERCP Procedure.
Status: UNKNOWN
Conditions: Patients Indicated for Periampullary or Pancreaticobiliary Examination
Interventions: DEVICE: CapsoCam® Plus (SV-3) capsule endoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Evaluation of High-Performance, Customized, Rapidly-Manufacturable Prosthetic Feet That Provide Improved Mobility
Status: UNKNOWN
Conditions: Amputation of Lower Limb Below Knee
Interventions: DRUG: Commercially-available energy storage and return prosthetic foot|DEVICE: MIT-Lower Leg Trajectory Error (LLTE) customized prosthetic feet
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p