pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Mitochondrial-related Platelet Transcript Expression Levels in Pre-diabetic Subjects Randomized to Metformin or Placebo
Status: COMPLETED
Conditions: Prediabetes
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Brain Mechanisms Underlying the Effect of the Motilin Receptor Agonist Erythromycin on Hunger in Normal Weight Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Erythromycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Impact of Lymphedema on Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer|Cancer Survivor|Lymphedema|Perioperative/Postoperative Complications
Interventions: OTHER: questionnaire administration|PROCEDURE: assessment of therapy complications|PROCEDURE: bioimpedance spectroscopy|PROCEDURE: quality-of-life assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Oral Doxycycline Regimen to Prevent Bacteremia Following Dental Procedures
Status: NOT_YET_RECRUITING
Conditions: Bacteremia|Endocarditis
Interventions: DRUG: Clindamycin|DRUG: Doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Core Stability Exercises With Surface Electromyography Biofeedback in Patients With Mechanical Low Back Pain
Status: NOT_YET_RECRUITING
Conditions: Low Back Pain
Interventions: PROCEDURE: Core stability exercises|DEVICE: Biofeedback training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of Oncogenes in Intrahepatic Cholangiocarcinoma or Mixed Hepatocellular-Cholangiocarcinoma in Tumor Tissue Samples
Status: COMPLETED
Conditions: Intrahepatic Cholangiocarcinoma|Mixed Hepatocellular Cholangiocarcinoma|Cholangiocarcinoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: NAFLD Among Patients With Chronic Kidney Disease and the Effect of Kidney Transplantation
Status: TERMINATED
Conditions: Non-Alcoholic Fatty Liver Disease|Chronic Kidney Diseases|PreDiabetes|Kidney Transplant
Interventions: DIAGNOSTIC_TEST: MR spectroscopy of the liver|DIAGNOSTIC_TEST: Fibroscan of the liver|DEVICE: Continuous glucose monitoring (CGM) for four days.|DIAGNOSTIC_TEST: Oral glucose tolerance test (OGTT)|DIAGNOSTIC_TEST: Intra venous glucose infusion (IIGI)|RADIATION: Dual Energy X-ray Absorptiometry (DEXA) scan|BIOLOGICAL: Blood samples|OTHER: Clinical and demographic data
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exploratory Cognition Study of Sertindole in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Sertindole|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Delirium Treatment With Transcranial Electrical Stimulation
Status: RECRUITING
Conditions: Delirium
Interventions: DEVICE: transcranial alternating current stimulation (tACS)|DEVICE: Sham transcranial alternating current stimulation (tACS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Superior vs Nasal/Temporal Laser Peripheral Iridotomy in Primary Angle Closure
Status: COMPLETED
Conditions: Glaucoma, Angle-Closure
Interventions: PROCEDURE: Laser peripheral iridotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Active Myeloid Target Compound Combinations in MDS/MPN Overlap Syndromes Overlap Syndromes (ABNL-MARRO)
Status: RECRUITING
Conditions: MDS/MPN
Interventions: DRUG: ASTX727|DRUG: Itacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transplantation of Reconstructed Renal Allografts Following Ex-Vivo Partial Nephrectomy
Status: NOT_YET_RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: PROCEDURE: Donor Radical and Partial Nephrectomy|PROCEDURE: Kidney Transplantation|PROCEDURE: Laparoscopic Radical Nephrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Trial Via Tranforaminal Approach Versus Epidural Catheter Via Interlaminar Approach
Status: COMPLETED
Conditions: Cervical Radiculopathy
Interventions: PROCEDURE: Transforaminal ESI with dexamethasone|PROCEDURE: Transforaminal catheter-targeted ESI with triamcinolone|DRUG: Dexamethasone Sodium Phosphate 10 MG/ML|DRUG: Lidocaine|DRUG: Triamcinolone Acetonide 40mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Foundational Ingredients of Robotic Gait Training for People With Spinal Cord Injury During Inpatient Therapy
Status: UNKNOWN
Conditions: Spinal Cord Injuries
Interventions: OTHER: Robotic Gait Training|OTHER: Usual Care Gait Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SINUS FLOOR WITH OSSEODENSIFICATION OR LATERAL WINDOW
Status: RECRUITING
Conditions: Sinus Tract|Dental Implant Failed
Interventions: PROCEDURE: Osseodensification with Versah system|PROCEDURE: Lateral window
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Laryngeal Mask Airway (LMA) for Surfactant Administration in Neonates
Status: COMPLETED
Conditions: Respiratory Distress Syndrome
Interventions: DEVICE: Nasal continuous positive airway pressure (nCPAP)|DEVICE: Laryngeal Mask Airway (LMA) to deliver surfactant|DRUG: Surfactants, Pulmonary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Immunotherapy Targeting Sarcomas
Status: UNKNOWN
Conditions: Sarcoma|Osteoid Sarcoma|Ewing Sarcoma
Interventions: BIOLOGICAL: Multiple sarcoma-specific CAR-T cells and sarcoma vaccines
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Mallinckrodt Electronic Device on Continuous Control of Tracheal Cuff Pressure
Status: COMPLETED
Conditions: Critical Illness
Interventions: DEVICE: Continuous control of Pcuff followed by manual control|DEVICE: Manual control of Pcuff followed by continuous control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DFD01 Spray HPA Axis Suppression Study in Adolescent Patients With Moderate to Severe Plaque Psoriasis
Status: TERMINATED
Conditions: Plaque Psoriasis
Interventions: DRUG: DFD01 Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Chiauranib in Combine With Capecitabine in TNBC
Status: RECRUITING
Conditions: Triple-negative Breast Cancer
Interventions: DRUG: Chiauranib|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NVD in Hypothermic HIE Neonates
Status: COMPLETED
Conditions: HIE - Perinatal Hypoxic - Ischemic Encephalopathy
Interventions: DRUG: N-acetylcysteine, NAC, and calcitriol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Muscle Energy Technique Versus Back Stretching Among Non-specific Low Back Pain-subacute
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: OTHER: Muscle energy technique of erector spinae muscle|OTHER: Muscle energy technique of quadratus lumborum muscle|OTHER: Stretching of erector spinae muscle|OTHER: Stretching of quadratus lumborum muscle|OTHER: Back strengthening exercises|OTHER: Thermotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Biological Therapy in Treating Patients With Refractory Solid Tumor or Lymphoma
Status: COMPLETED
Conditions: Lymphoma|Small Intestine Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: paclitaxel|DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benefits of High Flow Nasal Cannula Oxygen for Preoxygenation During Intubation in Non Severely Hypoxemic Patients
Status: COMPLETED
Conditions: Need for Intubation, No Severe Hypoxemia
Interventions: DEVICE: OPTIFLOW/ AIRVO|PROCEDURE: STANDARD Face Mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Cognitive Behavioral Therapy - Insomnia (CBT-I) Among Professional Firefighters
Status: COMPLETED
Conditions: Insomnia|Shift-Work Related Sleep Disturbance
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia for Firefighters (CBT-I-F)|DEVICE: Fitbit Inspire HR Wrist Worn Device (NCT04176926)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Effects of Green Tea on Gut Flora, Fat Absorption, Body Composition and Resting Energy Expenditure
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: placebo|DIETARY_SUPPLEMENT: green tea (757 mg/capsule [84.5 mg EGCG + 2.1 mg caffeine ]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Rehab CARES In USA: Clinical Trial
Status: RECRUITING
Conditions: Stroke|Hemiplegia
Interventions: DEVICE: Robot-Assisted Therapy with Rehab CARES system|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of TA-NIC to Assess the Efficacy and Safety of the Vaccine as an Aid to Smoking Cessation
Status: COMPLETED
Conditions: Smoking
Interventions: BIOLOGICAL: TA-NIC|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cisplatin and Radiation Therapy With or Without Tirapazamine in Treating Patients With Cervical Cancer
Status: TERMINATED
Conditions: Cervical Adenocarcinoma|Cervical Adenosquamous Cell Carcinoma|Cervical Squamous Cell Carcinoma|Stage IB Cervical Cancer|Stage IIA Cervical Cancer|Stage IIB Cervical Cancer|Stage III Cervical Cancer|Stage IVA Cervical Cancer
Interventions: DRUG: cisplatin|DRUG: tirapazamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Corifollitropin Alfa Followed by Menotropin for Poor Ovarian Responders Trial
Status: COMPLETED
Conditions: Infertility|Poor Ovarian Response
Interventions: DRUG: Corifollitropin alfa|DRUG: recombinant FSH|DRUG: Ganirelix|DRUG: hp HMG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protein in Feeding Strategies to Accelerate Muscle Recovery From ACL Reconstruction
Status: COMPLETED
Conditions: Rehabilitative Nutrition for Muscle Recovery From ACL Reconstruction
Interventions: OTHER: Diet Intervention_AP-CPT|OTHER: Diet Intervention_PP-PPT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tears Substitutions and Their Effects on Higher Order Aberrometery
Status: WITHDRAWN
Conditions: Dry Eye Syndrome
Interventions: OTHER: Preservative Free Saline|OTHER: Optive|OTHER: Refresh Moderate/Severe|OTHER: Systane|OTHER: Systane Ultra
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Interferon Alfa in Treating Children With HIV-Related Cancer
Status: COMPLETED
Conditions: Leukemia|Lymphoma|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: recombinant interferon alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MR-HIFU for Recurrent Gynaecological Cancer
Status: COMPLETED
Conditions: Cervical Cancer|Endometrial Cancer|Uterine Cancer|Ovarian Cancer|Vaginal Cancer|Vulvar Cancer
Interventions: DEVICE: Magnetic Resonance Image-guided High Intensity Focused Ultrasound (MR-HIFU)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ertugliflozin to Reduce Arrhythmic Burden in ICD/CRT patientS (ERASe-Trial) - a Phase III Study
Status: TERMINATED
Conditions: Heart Failure With Reduced Ejection Fraction|Heart Failure With Mid Range Ejection Fraction|Implantable Cardioverter-Defibrillators|Cardiac Resynchronization Therapy
Interventions: DRUG: Ertugliflozin 5 mg|DRUG: Placebo 5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Refining a Biobehavioral Intervention to Enhance Recovery Following Hematopoietic Stem Cell Transplantation
Status: COMPLETED
Conditions: Hodgkin's Lymphoma|Leukemia|Lymphoid Leukemia|Multiple Myeloma|Myeloid Leukemia|Non-hodgkin's Lymphoma|Myelodysplastic Syndrome
Interventions: BEHAVIORAL: Behavioral techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: One Year Study of Rifaximin Delayed Release (DR) Tablets in Crohn's Disease
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: DRUG: Rifaximin EIR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RCT to Evaluate the Cosmetic Efficacy of Demo-cosmetic Active Ingredient CLS02021
Status: COMPLETED
Conditions: Overall Skin Appearance|Dry Skin; Eczema
Interventions: OTHER: Cosmetic Active Ingredient CLS02021|OTHER: Placebo PLC01021
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Decreasing Over Screening and Treatment of Cervical Precancers in Young Women
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: OTHER: Provider Mobile Application (ProvAPP)|OTHER: ProvAPP + Patient Educational Tool (Tab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Relationship Between Rheumatoid Arthritis Severity and Cognition in the Elderly: The Role of Nociplastic Pain
Status: RECRUITING
Conditions: Rheumatoid Arthritis|Rheumatic Diseases|Rheumatoid Polyarthritis
Interventions: OTHER: Questionnaire and physical assessments
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Acceptability and Clinical, Cognitive and Brain Efficacy of the Pilot of a Computerized Psychotherapy Program Based on Behavioural and Cognitive Techniques in the Depressed Patient
Status: COMPLETED
Conditions: Depression
Interventions: OTHER: Software use
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Time on Generalization of Exposure-based Benefit
Status: NOT_YET_RECRUITING
Conditions: One Week Follow-up Assessment|Six Weeks Follow-up Assessment|Three Months Follow-up Assessment
Interventions: BEHAVIORAL: Exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Outpatient Palliative Care Improve Patient-centered Outcomes in Parkinson's Disease?
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: OTHER: Interdisciplinary outpatient palliative care|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Self-Management Program on Individuals With Scleroderma
Status: COMPLETED
Conditions: Scleroderma|Systemic Sclerosis
Interventions: BEHAVIORAL: Self Management Intervention Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Honey on Nocturnal Cough and Sleep Quality
Status: COMPLETED
Conditions: Cough|Sleep
Interventions: DIETARY_SUPPLEMENT: Eucalyptus honey|DIETARY_SUPPLEMENT: Labiatae honey|DIETARY_SUPPLEMENT: Citrus honey|DIETARY_SUPPLEMENT: Silan date extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Positron Emission Tomography (PET) Study With [11C]Raclopride to Determine Central D2 Dopamine Occupancy of SEROQUEL
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: SEROQUEL XR (quetiapine)|DRUG: SEROQUEL IR (quetiapine)|DRUG: radioligand [11C]raclopride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Complementary Feeding of Eggs on Infant Development and Growth in Guatemala: The Saqmolo Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Growth|Development; Delayed
Interventions: DIETARY_SUPPLEMENT: Eggs plus standard of care|OTHER: Standar of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: the Efficacy and Safety of Rulonilimab in Combination With Lenvatinib in Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Rulonilimab+Lenvatinib|DRUG: Rulonilimab placebo +Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First-in-human Study of CCW702 in Patients With Metastatic Castration Resistant Prostate Cancer
Status: TERMINATED
Conditions: Metastatic Castration-Resistant Prostate Adenocarcinoma
Interventions: DRUG: CCW702
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Mobility Via Robotic Exoskeletons in Local Rehabilitation Settings in Singapore
Status: COMPLETED
Conditions: Stroke|Spinal Cord Injuries|Spinal Cord Diseases
Interventions: DEVICE: robotic exoskeleton training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bioavailability Study of Tramadol/APAP Tablets Under Fed Conditions
Status: COMPLETED
Conditions: To Determine Bioequivalence Under Fed Conditions
Interventions: DRUG: Tramadol/ APAP|DRUG: Ultracet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of PUR003 on Asthma
Status: COMPLETED
Conditions: Asthma|Lung Diseases|Bronchial Diseases
Interventions: DRUG: PUR003|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Feasibility of Using an At-home Foot Temperature Monitoring Device (Thermidas)
Status: RECRUITING
Conditions: Foot Ulcer, Diabetic
Interventions: DEVICE: Thermidas Vista Telehealth App
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effects of a Nurse-led Transitional Burns Rehabilitation Programme
Status: COMPLETED
Conditions: Burns Multiple
Interventions: OTHER: Nurse-Led Transitional Burns Rehabilitation Programme (4Cs-TBuRP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigating Different Frequencies of Transcranial Electrical Stimulations in Dementia Population
Status: NOT_YET_RECRUITING
Conditions: Dementia
Interventions: DEVICE: Transcranial Direct Current Stimulation (tDCS)|DEVICE: Gamma Transcranial Alternating Current Stimulation (tACS)|DEVICE: Theta Transcranial Alternating Current Stimulation (tACS)|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Faecal Microbiota Transplantation in Irritable Bowel Syndrome
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome
Interventions: OTHER: Faecal microbiota transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of HepaStem in Patients With Cirrhotic and Pre-cirrhotic NASH Patients
Status: COMPLETED
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: DRUG: HepaStem
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Bioequivalence of Aprepitant and Fosaprepitant and the Effect of Food on Aprepitant Bioavailability (0869-165)
Status: COMPLETED
Conditions: Chemotherapy-Induced Nausea and Vomiting
Interventions: DRUG: aprepitant 165 mg|DRUG: Comparator: aprepitant 185 mg|DRUG: Comparator: fosaprepitant 150 mg|DRUG: Comparator: aprepitant with food
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Yeego! Healthy Eating & Gardening School-Based Randomized Controlled Trial
Status: COMPLETED
Conditions: Dietary Habits|Health Behavior|Eating Behavior
Interventions: BEHAVIORAL: Behavioral Gardening Exposure|BEHAVIORAL: Healthy Eating and Gardening Curriculum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mobile-based Lifestyle Intervention in Women With Glucose Intolerance After Gestational Diabetes
Status: COMPLETED
Conditions: Gestational Diabetes|Type 2 Diabetes Mellitus|Glucose Intolerance|Healthy Lifestyle
Interventions: BEHAVIORAL: mobile-based lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast Cancer
Status: COMPLETED
Conditions: Benign Breast Disease|Fibrocystic Disease of Breast|Fibroadenoma|Mastalgia
Interventions: DRUG: Tamoxifen|DRUG: Evening Primrose Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PM8002 or Placebo Plus Nab-Paclitaxel as First-line Treatment in Inoperable Locally Advanced/Metastatic Triple-negative Breast Cancer
Status: RECRUITING
Conditions: Triple Negative Breast Cancer(TNBC)
Interventions: DRUG: PM8002|DRUG: Nab-Paclitaxel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility Evaluation of Planning and Execution of Surgical Revascularization Solely Based on Coronary CTA and FFRCT in Patients With Complex Coronary Artery Disease (FASTTRACK CABG)
Status: UNKNOWN
Conditions: Coronary Artery Disease|Myocardial Ischemia|Coronary Disease|Heart Diseases|Cardiovascular Diseases|Arteriosclerosis|Arterial Occlusive Diseases|Vascular Diseases
Interventions: DIAGNOSTIC_TEST: Coronary computed tomography angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of a PIKA Rabies Vaccine Containing the PIKA Adjuvant With an Accelerated Regimen
Status: COMPLETED
Conditions: Rabies
Interventions: BIOLOGICAL: RABIPUR®|BIOLOGICAL: PIKA rabies vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cooling Fabrics and Exercise Performance in Endurance Athletes
Status: COMPLETED
Conditions: Cooling Fabrics|Exercise Performance|Thermoregulation
Interventions: OTHER: Cooling Fabric|OTHER: Placebo Garment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NanoTherm In Adjuvant Therapy of Glioblastoma Multiforme
Status: RECRUITING
Conditions: Glioblastoma Multiforme
Interventions: DEVICE: NanoTherm therapy|PROCEDURE: Glioma Resection|RADIATION: radiotherapy according to Stupp protocol|DRUG: chemotherapy according to Stupp protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Sugammadex and Neostigmine for Recovery From Rocuronium
Status: ACTIVE_NOT_RECRUITING
Conditions: Anesthesia
Interventions: PROCEDURE: using of sugammadex and neostigmine for reversal from rocuronium and assessment of response using ultrasound and nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: RSYR for Fatigue Reduction in Cancer Survivors
Status: COMPLETED
Conditions: Cancer-related Problem/Condition
Interventions: DRUG: RSYRT decoction|DRUG: Astragalus membranaceus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Clinical Outcomes of Distal Radius Fractures Treated Surgically With WALANT and Peripheral Nerve Block
Status: COMPLETED
Conditions: Distal Radius Fracture
Interventions: PROCEDURE: Open reduction and internal fixation (under WALANT)|PROCEDURE: Open reduction and internal fixation (under peripheral nerve block)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rapid Atrial Fibrillation Treatment Strategy
Status: UNKNOWN
Conditions: New Onset Atrial Fibrillation|Sepsis|Respiratory Failure
Interventions: DRUG: Amiodarone in Parenteral Dosage Form|DRUG: Amiodarone Pill|PROCEDURE: Direct Current Cardioversion (DCC)|DRUG: Rate-control therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Intravenous Ferric Carboxymaltose in Treatment of Anemia in Cancer Patients Undergoing Chemotherapy
Status: COMPLETED
Conditions: Anemia|Cancer
Interventions: DRUG: Ferric carboxymaltose (FCM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Response to Intermittent Pneumatic Compression Therapy in Head and Neck Cancer-Related Lymphedema
Status: COMPLETED
Conditions: Head and Neck Neoplasms|Head and Neck Lymphedema|Head and Neck Cancer
Interventions: DEVICE: Head and neck garments for pneumatic compression device|DRUG: NIRFLI with ICG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ergogenic Effects of Sportlegs
Status: COMPLETED
Conditions: Performance Enhancing Product Use
Interventions: DIETARY_SUPPLEMENT: Sportlegs|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Mezagitamab in Adults With Primary Immunoglobulin A Nephropathy Receiving Stable Background Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Kidney Disease|Glomerulonephritis
Interventions: DRUG: Mezagitamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Duloxetine in Chinese Solid Tumor Patients With Taxanes-induced Painful Peripheral Neuropathy
Status: RECRUITING
Conditions: Chemotherapy-induced Peripheral Neuropathy|Pain|Solid Tumor
Interventions: DRUG: Duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Efficacy of a Multiport Versus Uniport Flexible Catheter for Labor Epidural Analgesia
Status: COMPLETED
Conditions: Labor Pain
Interventions: DEVICE: Multiport flexible catheter|DEVICE: Uniport flexible catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 17-Dimethylaminoethylamino-17-Demethoxygeldanamycin (17-DMAG) in Treating Patients With Metastatic Solid Tumors or Tumors That Cannot Be Removed By Surgery
Status: UNKNOWN
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: alvespimycin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Arm Trial Evaluating the Efficacy and Safety of EVX-01 in Combination With Pembrolizumab in Adults With Unresectable or Metastatic Melanoma
Status: RECRUITING
Conditions: Melanoma Stage III|Melanoma Stage IV
Interventions: DRUG: EVX-01|DRUG: Pembrolizumab 25 MG/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Efficacy of Inarigivir in Non-cirrhotic, Hepatitis B e Antigen-negative Subjects Infected With HBV Virus and Receiving or Stopping Treatment With a NUC Inhibitor
Status: TERMINATED
Conditions: Hepatitis B|HBV|Hepatitis B, Chronic
Interventions: DRUG: Inarigivir soproxil|DRUG: Nucleoside/nucleotide (NUC) analogue inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RESEARCH PROTOCOL: Glaucoma Treatment Adherence and Persistence
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma
Interventions: BEHAVIORAL: motivational interviewing|BEHAVIORAL: three phone calls to remind patients to take their eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Itacitinib for the Treatment Steroid Refractory Immune Related Adverse Events Arising From Immune Checkpoint Inhibitors
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: DRUG: Itacitinib|DRUG: Corticosteroid|PROCEDURE: Endoscopic Procedure|PROCEDURE: Skin biopsy|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aspirin Twice a Day in Patients With Diabetes and Acute Coronary Syndrome
Status: COMPLETED
Conditions: Diabetes Mellitus|Acute Coronary Syndrome|Coronary Artery Disease|Obesity
Interventions: DRUG: Novel strategy Aspirin|DRUG: Conventional strategy Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epidural PCA on Pain Relief After L-spine Surgery
Status: COMPLETED
Conditions: Pain, Postoperative|Lumbar Spine Degeneration|Analgesia, Patient-Controlled|Epidural Anesthesia
Interventions: PROCEDURE: Epidural patient-controlled analgesia|PROCEDURE: Standard postoperative pain management
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Laser vs Clobetasol for Lichen Sclerosus
Status: RECRUITING
Conditions: Lichen Sclerosus
Interventions: DRUG: Clobetasol 0.05% Emollient Top Cream|DEVICE: Non-ablative CO2 Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of Intravenous Pro-Netupitant and Palonosetron Combination for the Prevention of Nausea and Vomiting
Status: COMPLETED
Conditions: Chemotherapy-Induced Nausea and Vomiting
Interventions: DRUG: Pro-netupitant/Palonosetron|DRUG: Netupitant/Palonosetron|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Allopurinol on the Risk of Cardiovascular Events in Patients With Cardiovascular Risk
Status: RECRUITING
Conditions: Cardiovascular Diseases|Uric Acid
Interventions: DRUG: Allopurinol 200 mg|DRUG: Optional intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots PROOF OF CONCEPT
Status: COMPLETED
Conditions: Lentigo Solar
Interventions: DEVICE: EC16 medical device (CE marked)|DEVICE: device prototype (810A-v1)|DEVICE: device prototype (810B-v1)|DEVICE: device prototype (810C-v1)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Yutiq Steroid Insert During Glaucoma Tube Implant Surgery
Status: RECRUITING
Conditions: Glaucoma
Interventions: DRUG: Yutiq 0.18 MG Drug Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Oxytocin on Complex Social Cognition in Autism Spectrum Disorders
Status: COMPLETED
Conditions: Autism|ASD
Interventions: DRUG: Syntocinon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bone Remodeling Around a Trabecular Titanium Cup in Total Hip Arthroplasty
Status: RECRUITING
Conditions: Total Hip Arthroplasty
Interventions: DEVICE: Jump System Traser® cup|DEVICE: Jump System HAX-Pore® cup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pentostatin, and Rituximab With and Without Cyclophosphamide for Previously Untreated B-Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: B-Chronic Lymphocytic Leukemia
Interventions: DRUG: Pentostatin|DRUG: Rituximab|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acceleration of the Kinetics of Diffusion of Gadolinium in the Perilymphatic Structures of the Inner Ear.
Status: UNKNOWN
Conditions: Inner Ear ; Meniere's Disease; Imaging
Interventions: OTHER: Magnetic Resonance Imaging with Single dose of gadobutrol (Gd-DO3A-butrol, Gadovist® 0.1 mmol/kg, 1 mmol/mL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Stented Biliary Anastomosis in Living Donor Liver Transplantation
Status: COMPLETED
Conditions: Liver Transplant
Interventions: PROCEDURE: living donor liver transplantation with internal biliary stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Pistachio Intake on Insulin Resistance and Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Pistachios|OTHER: control diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BAY14-2222 Prophylaxis and Joint Function Improvement (Adults)
Status: COMPLETED
Conditions: Hematologic Disease|Hemophilia A
Interventions: DRUG: Kogenate (BAY14-2222)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The STRENGTHEN Study
Status: RECRUITING
Conditions: Cognitive Flexibility|Emotional Regulation
Interventions: OTHER: Healthy Minds Program|OTHER: Sham Meditation Didactic Material|DEVICE: Sham Stimulation in Lab|DEVICE: Stimulation in Lab|DEVICE: MRI Scanner
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Medtronic RESOLUTE ONYX Core (2.25 mm - 4.0 mm) Clinical Study
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Resolute Onyx Stent - 2.25 mm - 4.0 mm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Lenvatinib for the Treatment of Serous Ovarian Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: High Grade Fallopian Tube Serous Adenocarcinoma|High Grade Ovarian Serous Adenocarcinoma|Peritoneal High Grade Serous Adenocarcinoma|Recurrent High Grade Fallopian Tube Serous Adenocarcinoma|Recurrent High Grade Ovarian Serous Adenocarcinoma|Recurrent Primary Peritoneal High Grade Serous Adenocarcinoma
Interventions: DRUG: Lenvatinib|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy of Ruxolitinib 1.5% Cream in Adult Subjects With Discoid Lupus Erythematosus
Status: RECRUITING
Conditions: Discoid Lupus Erythematosus
Interventions: DRUG: Ruxolitinib 1.5% cream|PROCEDURE: Application without occlusion in Area 1|PROCEDURE: Application under occlusion at night in Area 2|PROCEDURE: Application under occlusion at night in Area 1|PROCEDURE: Application without occlusion in Area 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cervical Foraminal Stenosis and Radiculopathy - ACDF Versus Minimal Invasive Posterior Cervical Foraminotomy.
Status: UNKNOWN
Conditions: Radiculopathy
Interventions: PROCEDURE: ACDF|PROCEDURE: minimal invasive Posterior Cervical Foraminotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Granulocyte-Macrophage Stimulating Factor (GM-CSF) in Peripheral Arterial Disease
Status: RECRUITING
Conditions: Peripheral Artery Disease (PAD)
Interventions: DRUG: GM-CSF|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Acceleration-Based Prosthetic Knee Locking Mechanism for Reducing the Risk of Falling in Transfemoral Amputees
Status: UNKNOWN
Conditions: Transfemoral Amputees
Interventions: DEVICE: Locking mechanism for prosthetic knee
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery
Status: COMPLETED
Conditions: Heart Valve Diseases
Interventions: PROCEDURE: remote ischemic pre and postconditioning (RIPC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Safety and Efficacy Trial of Istaroxime for Cardiogenic Shock Stage C
Status: RECRUITING
Conditions: Cardiogenic Shock
Interventions: DRUG: Istaroxime|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stress Ulcer Prophylaxis in the Intensive Care Unit
Status: COMPLETED
Conditions: Gastrointestinal Bleeding|Stress Ulcers
Interventions: DRUG: Pantoprazole|OTHER: Saline (0.9%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pain and Safety of Restylane With and Without Lidocaine for Correction of Moderate and Severe Nasolabial Folds
Status: COMPLETED
Conditions: Nasolabial Fold
Interventions: DEVICE: Restylane Lidocaine|DEVICE: Restylane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Misoprosotol and Isosorbide Mononitrate for Induction of Second Trimester Abortion
Status: COMPLETED
Conditions: Second Trimester Abortion
Interventions: DRUG: Misoprostol|DRUG: isosorbide mononitrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Continuous Versus Bolus Administration of G-CSF in Children With Cancer
Status: RECRUITING
Conditions: Pediatric Cancer|Neutropenia|Lenograstim|Filgrastim|G-CSF
Interventions: DEVICE: G-CSF administration (bolus injection versus intravenous infusion)|DRUG: G-CSF administration (bolus injection versus intravenous infusion)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Acupuncture on Sjögren's Syndrome
Status: COMPLETED
Conditions: Sjogren's Syndrome
Interventions: OTHER: Acupuncture|OTHER: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adaptive Closed Loop Neuromodulation and Neural Signatures of Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DEVICE: Adaptive DBS (Activa PC+S Neurostimulator)|DEVICE: Continuous DBS (Activa PC+S Neurostimulator)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Efficacy of Acupuncture in the Treatment of Temporomandibular Disorders (TMD)
Status: UNKNOWN
Conditions: Temporomandibular Disorders
Interventions: DEVICE: Acupuncture|DEVICE: The park sham needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Saddle Block With IT Morphine for Penile Inversion Vaginoplasty
Status: NOT_YET_RECRUITING
Conditions: Pain, Postoperative
Interventions: PROCEDURE: Saddle block|PROCEDURE: pudendal nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Antiemetic Regimen for Prevention of PONV in Breast Surgery Patients
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Aprepitant, Dexamethasone, Ondansetron|DRUG: Aprepitant, Dexamethasone, Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: TITLE: An Open, Non-comparative, Multi-centre Post Marketing Clinical Follow-up (PMCF) Investigation to Evaluate Performance and Safety on Diabetic Foot Ulcer, DFU, When Using Mepilex Transfer Ag as Intended
Status: COMPLETED
Conditions: Diabetic Foot Ulcers
Interventions: DEVICE: Mepilex Transfer Ag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Suitability of an Infant Formula With L-5-Methyltetrahydrofolate for the Particular Nutritional Use in Infants
Status: COMPLETED
Conditions: Growth and Development
Interventions: OTHER: infant formula containing folic acid|OTHER: infant formula containing MTHF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of HBVaxpro40© and Fendrix© in Patients With Chronic Liver Disease.
Status: COMPLETED
Conditions: Liver Disease Chronic|Hepatitis B Virus
Interventions: BIOLOGICAL: Fendrix or HBVAXPRO 40
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase I/II Study for the Safety and Efficacy of Panitumumab in Combination With TAS-102 for Patients With Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Panitumumab + TAS-102
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT