pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Prevalence of Pulmonary Hypertension (PAH) in Patients With Thalassemia
Status: COMPLETED
Conditions: Thalassemia Major|Thalassemia Intermedia|Pulmonary Arterial Hypertension
Interventions: OTHER: Physician standard-of-care according to ESC/ERS Guidelines
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Letrozole Versus Clomiphene Citrate on Ovulation Induction in Patients With Polycystic Ovarian Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of SARS-CoV-2 mRNA Vaccine (SYS6006) in Chinese Healthy Older Adults.
Status: ACTIVE_NOT_RECRUITING
Conditions: SARS-CoV-2
Interventions: BIOLOGICAL: 20 μg dose of SYS6006|BIOLOGICAL: 30 μg dose of SYS6006|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Chaplain-Delivered Compassion Meditation to Improve Quality of Life in Patients Receiving a Stem Cell Transplant
Status: COMPLETED
Conditions: Lymphoma|Plasma Cell Myeloma
Interventions: OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Spiritual Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pay-it-forward Gonorrhea and Chlamydia Testing Among Men in China
Status: ACTIVE_NOT_RECRUITING
Conditions: Gonorrhea
Interventions: BEHAVIORAL: Standard Pay-it-forward|BEHAVIORAL: Community Engaged Pay-it-forward|OTHER: Control arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Anti-PSMA CAR NK Cell (TABP EIC) in Metastatic Castration-Resistant Prostate Cancer
Status: UNKNOWN
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: TABP EIC|BIOLOGICAL: Cyclophosphamide|BIOLOGICAL: fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IK-5001 for the Prevention of Remodeling of the Ventricle and Congestive Heart Failure After Acute Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction|Congestive Heart Failure|ST-Elevation Myocardial Infarction
Interventions: DEVICE: IK-5001|DEVICE: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Temocillin in Urinary Tract Infection Due to ESBL Producing and AmpC Hyperproducing Enterobacteriaceae
Status: UNKNOWN
Conditions: Urinary Tract Infections
Interventions: DRUG: Temocillin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sugar Sweetened Beverages (SSB)- Effects on Metabolism
Status: COMPLETED
Conditions: Metabolism
Interventions: PROCEDURE: Soft drink consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Radiation Therapy, Chemotherapy, and Bevacizumab in Treating Patients With Recurrent, Unresectable or Stage III or Stage IV Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: carboplatin|DRUG: chemoprotection|DRUG: paclitaxel|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mitomycin as a Hyperthermic Peritoneal Perfusion in Treating Patients With Malignant Ascites
Status: TERMINATED
Conditions: Metastatic Cancer
Interventions: DRUG: mitomycin C
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics (PK) of Antistaphylococcal Antibiotics in Infants (NICHD-2012-02-Staph Trio)
Status: COMPLETED
Conditions: Systemic Infection
Interventions: DRUG: Antibiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial Evaluating a mRNA-VLP Vaccine's Immunogenicity and Safety for COVID-19
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19|SARS-CoV-2 Infection
Interventions: BIOLOGICAL: AZD9838|BIOLOGICAL: Licensed mRNA vaccine|BIOLOGICAL: AZD6563
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Biofeedback Footwear in Parkinson's Disease: Assessment of Functional Motor Abilities and Locomotion
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease|Gait Disorders
Interventions: OTHER: Greater plantar feedback shoes|OTHER: Neutral gym shoes|OTHER: Barefoot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of CMNa Combined With Definitive Concurrent Chemoradiotherapy for Locally Advanced ESCC
Status: COMPLETED
Conditions: Esophageal Neoplasms
Interventions: DRUG: Sodium Glycididazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Perception of Pain During Obstructive Sleep Apnea Syndrome in Obese Patient
Status: COMPLETED
Conditions: Obesity|Obstructive Sleep Apnea Syndrome
Interventions: DEVICE: Pain perception tests (mechanical : VON FREY ELECTRONIQUE or electrical stimulus : PAIN MATCHER®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Testing the Use of Combination Immunotherapy Treatment (N-803 [ALT-803] Plus Pembrolizumab) Against the Usual Treatment for Advanced Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lung Non-Small Cell Carcinoma|Recurrent Lung Non-Small Cell Carcinoma|Stage III Lung Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8|Stage IIIB Lung Cancer AJCC v8|Stage IIIC Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: DIETARY_SUPPLEMENT: Cobalamin|DRUG: Dexamethasone|DRUG: Docetaxel|DIETARY_SUPPLEMENT: Folic Acid|DRUG: Gemcitabine|DRUG: Nogapendekin Alfa|BIOLOGICAL: Pembrolizumab|DRUG: Pemetrexed|BIOLOGICAL: Ramucirumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Chemotherapy Regimens in Treating Children With Relapsed or Progressive Rhabdomyosarcoma
Status: COMPLETED
Conditions: Alveolar Childhood Rhabdomyosarcoma|Embryonal Childhood Rhabdomyosarcoma|Embryonal-botryoid Childhood Rhabdomyosarcoma|Previously Treated Childhood Rhabdomyosarcoma|Recurrent Childhood Rhabdomyosarcoma
Interventions: DRUG: vincristine sulfate|DRUG: irinotecan hydrochloride|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: ifosfamide|DRUG: etoposide|DRUG: tirapazamine|BIOLOGICAL: filgrastim|BIOLOGICAL: sargramostim|OTHER: pharmacological study|OTHER: pharmacogenomic studies|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Empagliflozin in Adults With Type 1 Diabetes on Closed Loop Insulin System
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: 14-day outpatient intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety/ Efficacy of T-VEC in Japanese Subjects With Unresectable Stage IIIB-IV Malignant Melanoma
Status: COMPLETED
Conditions: Unresectable Stage IIIB-IV Malignant Melanoma
Interventions: DRUG: Talimogene laherparepvec
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase II/III Study of the Efficacy and Safety of MacuCLEAR MC-1101 in Treating DryAge-Related Macular Degeneration
Status: UNKNOWN
Conditions: Non-Exudative Age Related Macular Degeneration
Interventions: DRUG: MC-1101|DRUG: MC-1101 Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cannabidiol and Older Adult Cannabis Users
Status: RECRUITING
Conditions: Sleep|Anxiety|Depression|Pain
Interventions: DRUG: fsCBD Cannabidiol|DRUG: bsCBD Cannabidiol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Pharmacokinetic and Pharmacodynamic Properties of Biocon's Insulin R U-500 With Humulin® R U-500 (US Reference Product) in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: Biocon's Human Insulin R U-500|BIOLOGICAL: Humulin® R U-500 (US Reference Product)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Value of Diffusion-weighted Imaging in Evaluating the Early Efficacy of Liver Metastasis in Colorectal Cancer
Status: UNKNOWN
Conditions: DWI-MRI
Interventions: DEVICE: Diffusion weighted magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: The Effect of Oral Polymeric Diet Enriched With TGF-beta 2 (Modulen) on Clinical Response and Mucosal Healing in Adult Patients With Newly Diagnosed Crohn's Disease
Status: UNKNOWN
Conditions: Crohn Disease
Interventions: DIETARY_SUPPLEMENT: Modulen|DRUG: Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Italian Study on the Cardiovascular Effects of Systolic Blood Pressure Control - CARDIOSIS Study
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Triatec 10 mg|DRUG: Triatec HCT 5|DRUG: Lasix 25|DRUG: Micardis 80 mg|DRUG: Micardis plus 80/12.5|DRUG: Catapresan TTS 2|DRUG: Norvasc 10 mg|DRUG: Triatec 5 mg|DRUG: Pluscor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Lottery Incentive Nudges to Increase Influenza Vaccinations
Status: COMPLETED
Conditions: Influenza|Vaccination|Health Promotion|Health Behavior
Interventions: BEHAVIORAL: Reminder|BEHAVIORAL: Financial incentive|BEHAVIORAL: Lottery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Actigraphy and Neonatal Abstinence Syndrome of Hospitalized Newborn in Intensive Care Units
Status: UNKNOWN
Conditions: Neonatal Abstinence Syndrome
Interventions: DEVICE: Actigraphy, eTact
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Chemotherapy and Monoclonal Antibody Therapy in Treating Patients With B-cell Non-Hodgkin's Lymphoma That Has Relapsed Following Peripheral Stem Cell Transplantation
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: vinorelbine ditartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention to Improve HIV Care Retention by Addressing Stigma Stigmatized Environments
Status: RECRUITING
Conditions: HIV I Infection
Interventions: BEHAVIORAL: Uniform Standard of Care Counseling|BEHAVIORAL: Behavioral Self-Regulation Skills Counseling|BEHAVIORAL: Behavioral Self-Regulation Skills Counseling + Stigma Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Skin-to-skin Contact on Cortical Activity During Painful Procedures on Preterm Infants in the NICU
Status: UNKNOWN
Conditions: Pain, Acute|Infant, Newborn|Electroencephalography
Interventions: BEHAVIORAL: Skin-to-skin contact|DRUG: 24% oral sucrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rivogenlecleucel Donor Lymphocyte Immunotherapy in Treating Patients With Recurrent Blood Cancers After Stem Cell Transplant
Status: WITHDRAWN
Conditions: Acute Bilineal Leukemia|Myelodysplastic/Myeloproliferative Neoplasm|Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable|Myeloproliferative Neoplasm|Recurrent Acute Biphenotypic Leukemia|Recurrent Acute Lymphoblastic Leukemia|Recurrent Acute Myeloid Leukemia|Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm|Recurrent Chronic Lymphocytic Leukemia|Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Recurrent Chronic Myelomonocytic Leukemia|Recurrent Myelodysplastic Syndrome
Interventions: BIOLOGICAL: Rivogenlecleucel|DRUG: Rimiducid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Glibenclamide Combined With Rt-PA in Acute Cerebral Embolism
Status: COMPLETED
Conditions: Acute Stroke
Interventions: DRUG: Glibenclamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ecological Momentary Assessment in Patients With Restless Legs Syndrome
Status: RECRUITING
Conditions: Restless Legs Syndrome
Interventions: OTHER: Clinical assessment|BEHAVIORAL: auto-questionnaires|DEVICE: Ecological Momentary Assessment (EMA)|DEVICE: activity-rest cycle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Thyroid Function in Critically Ill Patients With Acute Kidney Injury
Status: COMPLETED
Conditions: Secondary Hypothyroidism
Interventions: DIAGNOSTIC_TEST: Assessment of TSH, fT3, fT4,TRH, TT3, TT4, rT3 in patients with CVVHDF
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Drug-Drug Interaction Study to Evaluate the Effect of Rifampin on the Pharmacokinetics of Apremilast
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Apremilast|DRUG: Rifampin Oral Capsules|DRUG: Rifampin IV Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Lintuzumab-Ac225 in Older Acute Myeloid Leukemia (AML) Patients
Status: COMPLETED
Conditions: AML
Interventions: DRUG: Cytarabine (Phase 1 only)|BIOLOGICAL: Lintuzumab-Ac225|DRUG: Furosemide (Phase 1 only)|DRUG: Spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: What is the Tympanic Membrane Healing Time After Insertion of a Gelfoam PE Tube?
Status: COMPLETED
Conditions: Eustachian Tube Dysfunction|Sudden Hearing Loss|Meniere Disease
Interventions: DEVICE: PE tube
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Bioequivalence Study of Two Products of Apremilast 30 mg Tablets in Healthy, Adult, Human Subjects
Status: COMPLETED
Conditions: Psoriasis and Psoriatic Arthritis
Interventions: DRUG: Apremilast 30 mg Tablets|DRUG: Otezla 30 mg film-coated tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison the Topical Anesthesia and Retrobulbar Anesthesia for 27-gauge Vitrectomy for Vitreous Floaters
Status: UNKNOWN
Conditions: Perioperative Pain Experiences
Interventions: DRUG: vitrectomy under topical anesthesia [Proparacaine HCL (Alcaine®)]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Bioavailability of the Test Formulation of Amlodipine 10 mg Tablets (Torrent Pharmaceuticals Limited) Compared to a 10 mg Dose of Norvasc® (Pfizer) in 22 Fasted, Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Amlodipine besylate|DRUG: Norvasc
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Different Order of Concurrent Training on Improving Visceral Adipose Tissue and Insulin Resistance.
Status: COMPLETED
Conditions: Fat Burn|Aerobic Exercise|Resistance Exercise
Interventions: BEHAVIORAL: aerobic exercise|BEHAVIORAL: resistance exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vonoprazan in Helicobacter Pylori Treatment an RCT
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Omeprazole 20 MG Capsule; Amoxicillin 1000 MG; Clarithromycin 500 MG|DRUG: Vonoprazan 20 MG; Amoxicillin 1000 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Fidaxomicin in Pediatric Subjects With Clostridium Difficile-associated Diarrhea (CDAD)
Status: COMPLETED
Conditions: Clostridium Difficile-associated Diarrhea
Interventions: DRUG: fidaxomicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Cost-Effectiveness of Four Formulations of Food Supplements for the Prevention of Wasting and Stunting in Burkina Faso
Status: COMPLETED
Conditions: Child Malnutrition
Interventions: DIETARY_SUPPLEMENT: CSB14|DIETARY_SUPPLEMENT: RUSF1|DIETARY_SUPPLEMENT: SC+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Anti-oxidative Influence From Pomegranate Tablets on Male Sperm Quality in Couples Undergo Infertility Treatments Due to Male Infertility.
Status: UNKNOWN
Conditions: Male Infertility With Severe Oligo-terato-asteno-spermia
Interventions: DIETARY_SUPPLEMENT: Pomegranate pills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Coronary Computed Tomographic Angiography in Emergency Department Chest Pain Patients at Intermediate Risk of Acute Coronary Syndrome
Status: UNKNOWN
Conditions: Acute Coronary Syndrome|Acute Myocardial Infarction|Unstable Angina|Coronary Disease|Coronary Stenosis
Interventions: PROCEDURE: Coronary Computed Tomographic Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluate 4 Different Formulations of Meningococcal Serogroups A, C, W-135, Y Conjugate Vaccine When Given as 1 Dose to Healthy Subjects Aged 15-19 Yrs
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: Meningococcal (vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: A Dose-ranging Trial of OPC-131461 in Cardiac Edema (Congestive Heart Failure [CHF])
Status: RECRUITING
Conditions: Cardiac Edema (CHF)
Interventions: DRUG: OPC 131461 10mg group|DRUG: OPC 131461 5mg group|DRUG: OPC 131461 2mg group|DRUG: OPC 131461 1mg group|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acupressure in Preventing Nausea and Vomiting in Young Cancer Patients Receiving Chemotherapy
Status: COMPLETED
Conditions: Nausea and Vomiting|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: PROCEDURE: acupressure therapy|PROCEDURE: sham intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CellFX® nsPFA™ Cardiac Surgery System to Treat Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation|Surgery
Interventions: DEVICE: CellFX® nsPFA™ Cardiac Surgery System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjunct VR Pain Management in Acute Brain Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury|Headaches Posttraumatic|Trauma|Pain, Acute
Interventions: BEHAVIORAL: Virtual Reality Session (VR Blu)|BEHAVIORAL: Tablet-based Session (Tablet Blu)|BEHAVIORAL: Use of Virtual Reality Head Mounted Display without Content (VR Blank)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Substrate Metabolism, Growth Hormone Signaling (GH), and Insulin Sensitivity During GH and Ketone Bodies Infusion
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Somatropin|OTHER: Ketone bodies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Oral Melatonin as Premedication During MAC for Patients Undergoing Loco-regional Chronic Subdural Hematoma Evacuation
Status: COMPLETED
Conditions: Monitored Anaesthesia Care|Loco-regional Chronic Subdural Hematoma Evacuation
Interventions: DRUG: Placebo (Group P)|DRUG: Melatonin (Group M)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Network Of Clinical Research Studies On Craniosynostosis, Skull Malformations With Premature Fusion Of Skull Bones
Status: ACTIVE_NOT_RECRUITING
Conditions: Craniosynostosis
Interventions: OTHER: Craniosynostosis Network Environmental Survey|OTHER: 2D/3D Photography|PROCEDURE: Buccal Swab Cell Sampling|PROCEDURE: Blood sampling|PROCEDURE: Skin Biopsy|PROCEDURE: Tissues from a Clinically Indicated Procedure|PROCEDURE: Pre-operative CT Scan Image Files.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PTH & Ibandronate Combination Study (PICS)
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: PTH(1-84)|DRUG: Ibandronate|OTHER: Placebo injection|OTHER: Placebo pills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adipose-derived Stem Cell Conditioned Media as a Novel Approach for Hair Regrowth in Male Androgenetic Alopecia
Status: COMPLETED
Conditions: Alopecia, Androgenetic|Hair Loss/Baldness
Interventions: COMBINATION_PRODUCT: Non-concentrated adipose-derived stem cell conditioned media and 5% Minoxidil|COMBINATION_PRODUCT: Concentrated adipose-derived stem cell conditioned media and 5% Minoxidil|COMBINATION_PRODUCT: Placebo and 5% Minoxidil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reduced Intensity Double Umbilical Cord Blood Transplantation
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma|Hodgkin's Lymphoma|Multiple Myeloma|Chronic Lymphocytic Leukemia|Acute Myelogenous Leukemia
Interventions: DRUG: Fludarabine|DRUG: Melphalan|RADIATION: Total Body Radiation|BIOLOGICAL: Cord Blood
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Sulfadoxine/ Pyrimethamine Dispersible Tablets in Healthy Subjects Under Fasting Conditions
Status: UNKNOWN
Conditions: Bioequivalence
Interventions: DRUG: Sulfadoxine/Pyrimethamine dispersible tablets, 250 mg sulfadoxine / 12.5 mg pyrimethamine & 500 mg sulfadoxine / 25 mg pyrimethamine|DRUG: G-COSPE® tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cognitive Remediation and Transcranial Direct Current Stimulation in Severe Mental Illness (SMI)
Status: NOT_YET_RECRUITING
Conditions: Severe Mental Illness
Interventions: OTHER: Cognitive remediation + active tDCS|OTHER: Cognitive remediation + sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Image and Model Based Analysis of Lung Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DIAGNOSTIC_TEST: Pulmonary Function Test|DIAGNOSTIC_TEST: CT Scans|BEHAVIORAL: Questionnaires|DIAGNOSTIC_TEST: MRI|BIOLOGICAL: Xenon gas
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Of Capecitabine Combined With Camrelizumab For Non-pCR TNBC With TLS After Neoadjuvant Chemoterapy
Status: RECRUITING
Conditions: Breast Neoplasms
Interventions: DRUG: Carrellizumab + Capecitabine|DRUG: Placebo + Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Shortened Uncuffed Endotracheal Tube as a Nasopharyngeal Airway in Training in Fiberoptic Intubation
Status: COMPLETED
Conditions: Surgery
Interventions: OTHER: Group I|OTHER: Group II (NPA group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Variability in Transcranial Doppler Technique in Neuro-Critical Care Patients
Status: UNKNOWN
Conditions: Cerebral Aneurysm|Stroke|Vasospasm, Cerebral|Subarachnoid Hemorrhage, Aneurysmal|Aneurysmal Subarachnoid Hemorrhage|Cerebral Ischemia
Interventions: DIAGNOSTIC_TEST: Transcranial Doppler
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fruquintinib Plus Capecitabine Versus Bevacizumab Plus Capecitabine as Maintenance Therapy Following First-line Treatment for Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: Fruquintinib Plus Capecitabine|DRUG: Bevacizumab Plus Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transversus Thoracis Muscle Plane Block for Sternotomy Pain in Cardiac Surgery
Status: COMPLETED
Conditions: Pain, Postoperative|Surgical Wound|Cardiac Event
Interventions: PROCEDURE: Transversus thoracis muscle plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Treatment of Thoracic Aortic Aneurysms and Dilatation in Combination With Tricuspid and Bicuspid Aortic Valves.
Status: RECRUITING
Conditions: Ascending Aorta Aneurysm|Dilation of the Ascending Aorta
Interventions: OTHER: aortic prosthetics
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dexamethasone Regimens for Prophylaxis of Paclitaxel-associated Hypersensitivity Reaction
Status: COMPLETED
Conditions: Hypersensitivity Reaction
Interventions: DRUG: Intravenous Dexamethasone|DRUG: Oral Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Variability in Micro-CT Imaging Results to Quantify Dialyzer Clotting
Status: COMPLETED
Conditions: Hemodialysis Complication|Anticoagulants
Interventions: OTHER: anticoagulation dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Robatumumab (SCH 717454, MK-7454) in Combination With Different Treatment Regimens in Pediatric Participants With Advanced Solid Tumors (P05883, MK-7454-006)
Status: TERMINATED
Conditions: Neoplasms|Solid Tumors|Bone Cancer|Kidney Tumor|Neuroblastoma
Interventions: DRUG: Temozolomide|DRUG: Vincristine|DRUG: Ifosfamide|DRUG: Irinotecan|BIOLOGICAL: Robatumumab|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of RTA 901 in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: RTA 901 Capsules, 10 or 40 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sigh in Acute Hypoxemic Respiratory Failure
Status: COMPLETED
Conditions: Respiratory Failure|Acute Respiratory Distress Syndrome|Ventilator Lung
Interventions: PROCEDURE: Sigh|PROCEDURE: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Pharmacokinetic & Dose-Escalation Study of KD019 in Subjects With Autosomal Dominant Polycystic Kidney Disease
Status: COMPLETED
Conditions: Polycystic Kidney, Autosomal Dominant
Interventions: DRUG: Tesevatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Rehabilitation With ALA, ALC, Resveratrol and Vitamin D in Discogenic Sciatica in Young People
Status: COMPLETED
Conditions: Sciatic Radiculopathy
Interventions: OTHER: supplementation|OTHER: rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biofeedback Gait Retraining for Stiff Knee Gait Correction
Status: UNKNOWN
Conditions: Brain Injury
Interventions: OTHER: Sequential switched feedback training on the knee and the hip (Condition A)|OTHER: Feedback training on the knee alone (Condition B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: ctDNA Methylation for Epithelial Ovarian Cancer
Status: RECRUITING
Conditions: Epithelial Ovarian Cancer|Circulating Tumor DNA|DNA Methylation|Non-invasive Diagnosis|CA125|Human Epididymis Protein 4|Imaging Evaluation|Survival Prognosis
Interventions: DIAGNOSTIC_TEST: CDO1 and HOXA9 methylation assay
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Renal Function Assessment in the Elderly Using Plasma Creatinine Assay and Lean Body Mass Measurement
Status: UNKNOWN
Conditions: Renal Function
Interventions: OTHER: measurement of morphological parameters|BIOLOGICAL: a blood sample|BIOLOGICAL: albumin or blood in urine|DEVICE: Dual X-ray absorptiometry (DXA)|DEVICE: Bioelectric Impedance Spectroscopy (BIS)|BIOLOGICAL: 51Cr-EDTA plasma clearance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Tolerance and Mode of Administration of Cyto-selective Cryotherapy Treatments in Face Brown Spots: Proof of Concept
Status: COMPLETED
Conditions: Solar Lentigo
Interventions: DEVICE: (810A-v1) device prototype|DEVICE: (810B-v1) device prototype|DEVICE: (810C-v1) device prototype
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Dietary Protein Intake From Beef/Pork and Soy/Legumes on Appetite, Mood, and Weight Loss
Status: COMPLETED
Conditions: Appetite|Mood|Weight Loss
Interventions: OTHER: Beef/Pork|OTHER: Soy/Legumes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Lenalidomide in Combination With Bevacizumab, Sorafenib, Temsirolimus, or 5-Fluorouracil, Leucovorin, Oxaliplatin (FOLFOX)
Status: COMPLETED
Conditions: Advanced Cancers
Interventions: DRUG: Lenalidomide|DRUG: Bevacizumab|DRUG: Sorafenib|DRUG: Temsirolimus|DRUG: Lenalidomide|DRUG: Oxaliplatin|DRUG: Leucovorin|DRUG: 5-fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eye Movements Recording Using a Smartphone: Comparison to Standard Video-oculography in Patients With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: OTHER: Eye-Tracker®T2 + e-VOG|OTHER: e-VOG + Eye-Tracker®T2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neonatal Gastro-Esophageal Reflux Disease (GERD) Management Trial
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: OTHER: Study Arm - acid suppression plus feeding bundle|OTHER: Conventional arm - acid suppression only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Placebo-Controlled Trial of Simvastatin on Subarachnoid Hemorrhage-Induced Vasospasm
Status: COMPLETED
Conditions: Subarachnoid Hemorrhage|Delayed Vasospasm
Interventions: DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Pioglitazone in Hepatitis C
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Pioglitazone|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Spinal Cord Stimulation (SCS) on Painful Diabetic Peripheral Neuropathy (pDPN)
Status: RECRUITING
Conditions: Chronic Pain
Interventions: DEVICE: Spinal Cord Stimulation (SCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Healthy Volunteer Study Using 3 Different Formulations of Firategrast
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Firategrast immediate release tablet|DRUG: Firategrast modified release tablet|DRUG: Firategrast gastro-retentive solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bayesian Dose Adjustment of Immunosuppressants After Lung Transplantation
Status: TERMINATED
Conditions: Lung and Heart-lung Transplantation
Interventions: DRUG: Tacrolimus and MMF|DRUG: Tacrolimus and MMF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calcium Retention as Influenced by Dietary Components That Induce an Acid Load
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: High Meat - High Potential Renal Acid Load (PRAL) diet|OTHER: Low Protein - Low Potential Renal Acid Load (PRAL) diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cognitive Adaptive Training for Improving Medication Adherence, Symptoms, and Function in People With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Cognitive Adaptation Training|BEHAVIORAL: Pharm-Cognitive Adaptation Training|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Investigate the Impact of a Low Glycemic Index (GI) Diet on Body Mass Index and Obesity Related Cardiovascular and Hormonal Factors in Chinese Adolescents
Status: UNKNOWN
Conditions: Adolescence Obesity
Interventions: BEHAVIORAL: Low glycemic index diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Blood Levels of Sildenafil Following Administration of an Experimental Tablet vs. the Conventional Oral Tablet in Healthy Subjects
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Sildenafil|DRUG: Sildenafil|DRUG: Sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: SGLT2 Inhibitors in Transthyretin Amyloid Cardiomyopathy
Status: COMPLETED
Conditions: Transthyretin Amyloid Cardiomyopathy
Interventions: DRUG: Empagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune Disorders
Status: RECRUITING
Conditions: Autoimmune Disorders|Systemic Sclerosis
Interventions: DRUG: Tafasitamab|DRUG: Fludarabine phosphate|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accuracy of Magnetically Maneuvered Capsule Endoscopy for Detection of EGV in Patients With Cirrhosis
Status: COMPLETED
Conditions: Liver Cirrhosis|Portal Hypertension|Esophageal Varices|Gastric Varix
Interventions: DIAGNOSTIC_TEST: ds-MCE and EGD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rotational Atherectomy for Calcified lEsion By Smart Angioplasty Research Team (SMART-RACE)
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: Rotational Atherectomy by Rotablator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Short-course Radiotherapy Followed by the Combination of Immunotherapy and Chemotherapy in Locally Advanced Rectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Rectal Cancer
Interventions: DRUG: PD-1 antibody|DRUG: Capecitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid Ligating the Corresponding Inflow and Outflow Vessels Without Hilus Dissection During Hepatectomy
Status: UNKNOWN
Conditions: Cancer Progression
Interventions: PROCEDURE: hepatectomy (conventional method)|PROCEDURE: hepatectomy (rapid ligating)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Approach for the Prevention of Hypoglycemia Associated Autonomic Failure (HAAF)
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 1|Hypoglycemia|Hypoglycemia Unawareness
Interventions: DRUG: Naloxone|DRUG: Diazoxide|DRUG: Placebo (for Naloxone)|DRUG: Placebo (for Diazoxide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Empagliflozin on Ventricular Repolarization.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Coronary Heart Disease|Arrythmia, Cardiac
Interventions: DRUG: Empagliflozin 25 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Exercise-based Pre-habilitation in Bladder Cancer Patients Prior to Radical Cystectomy: a Feasibility Study
Status: UNKNOWN
Conditions: Bladder Cancer|Urothelial Carcinoma
Interventions: BEHAVIORAL: Exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Goserelin and Letrozole or Anastrozole in Premenopausal Patients With Stage II-III Estrogen Receptor-Positive Breast Cancer
Status: TERMINATED
Conditions: Estrogen Receptor-positive Breast Cancer|HER2-negative Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: DRUG: goserelin acetate|DRUG: letrozole|DRUG: anastrozole|DRUG: chemotherapy|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability of Epinastine Syrup Compared to Tablets in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Epinastine syrup|DRUG: Epinastine tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketamine for Veterans With Parkinson's Disease
Status: NOT_YET_RECRUITING
Conditions: Parkinson's Disease
Interventions: DRUG: Ketamine|DRUG: Remimazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effective Screening for Pain Study
Status: COMPLETED
Conditions: Pain|Pain Management
Interventions: BEHAVIORAL: NRS pain one week|BEHAVIORAL: PEG|BEHAVIORAL: DVPRS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Guadecitabine and Nivolumab in Treating Refractory Metastatic Colorectal Cancer
Status: WITHDRAWN
Conditions: Colorectal Adenocarcinoma|CpG Island Methylator Phenotype|Metastatic Microsatellite Stable Colorectal Carcinoma|Refractory Colorectal Carcinoma|Stage IV Colorectal Cancer AJCC v8|Stage IVA Colorectal Cancer AJCC v8|Stage IVB Colorectal Cancer AJCC v8|Stage IVC Colorectal Cancer AJCC v8
Interventions: DRUG: Guadecitabine|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-center Study to Determine the Prevalence and Influence of Pertussis on Subacute Cough in Shenzhen
Status: UNKNOWN
Conditions: Pertussis|Chronic Cough
Interventions: PROCEDURE: Blood sample|PROCEDURE: Data collection|PROCEDURE: Throat swab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial of IV OKN-007 in a Pilot Cohort of Human Recurrent Malignant Glioma Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Malignant Glioma
Interventions: DRUG: OKN-007
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Skin Imaging to Inform Laser Treatments
Status: TERMINATED
Conditions: Port-Wine Stain|Rosacea|Telangiectasia|Angioma
Interventions: DEVICE: Optical Coherence Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Reactive Hyperemia and Ultrasound-guided Puncture on the Success Rate of Radial Artery Cannulation (RadialHUS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Myocardial Ischemia|Cardiac Catheterization
Interventions: PROCEDURE: Methods for cannulating the radial artery in a cardiac catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Orelabrutinib in the Treatment of HP-positive Gastric MALT Lymphoma
Status: RECRUITING
Conditions: MALT Lymphoma of Stomach|Helicobacter Pylori Infection
Interventions: DRUG: Triple therapy for eradication of Helicobacter Pylori and Orelabrutinib|DRUG: Triple therapy for eradication of Helicobacter Pylori
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Augmented Reality Navigation Versus Traditional CT Guidance for Preoperative Localization of Pulmonary Nodules
Status: RECRUITING
Conditions: Pulmonary Nodule
Interventions: PROCEDURE: AR glasses-assisted pulmonary nodule puncture localization|PROCEDURE: CT-guided pulmonary nodule puncture localization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone Density in Children With IBD Treated With Amorphous Calcium or Commercial Crystalline Calcium
Status: WITHDRAWN
Conditions: Inflammatory Bowel Disease
Interventions: DIETARY_SUPPLEMENT: DENSITYTM caplets (marketed as Amorphical)|DIETARY_SUPPLEMENT: Calcium carbonate 600 mg once daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Photodynamic Therapy in Treatment of Peri-implantitis
Status: COMPLETED
Conditions: Peri-Implantitis
Interventions: PROCEDURE: Photodynamic (PDT) group|PROCEDURE: Chlorhexidine (CHX) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of KBP-7072 in Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: KBP-7072|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT