pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: First-in-Man Early Feasibility Study for Transcatheter HOCM Septal Ablation
Status: RECRUITING
Conditions: Hypertrophic Obstructive Cardiomyopathy
Interventions: DEVICE: TIRA catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Dried Plums (Prunes) vs. Polyethylene Glycol 4000 for Treatment of Functional Constipation in Children
Status: UNKNOWN
Conditions: Functional Constipation
Interventions: OTHER: Prunus domestica|DRUG: Polyethylene Glycol 4000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Absorption, Metabolism, Excretion and Absolute Bioavailability of EDG-5506 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer|Muscular Dystrophies|Muscular Disorders, Atrophic|Muscular Diseases|Musculoskeletal Diseases|Neuromuscular Diseases|Nervous System Diseases|Genetic Diseases, Inborn
Interventions: DRUG: EDG-5506 Tablet|DRUG: Radiolabeled EDG-5506 Suspension|DRUG: Radiolabeled EDG-5506 Intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Bronchial Asthma With Borage and Echium Seed Oils
Status: COMPLETED
Conditions: Bronchial Asthma
Interventions: DRUG: Borage Seed Oil and Echium Seed Oil|DIETARY_SUPPLEMENT: Corn Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: V/Q Matching Variations With PEEP in ARDS According to Compliance-based Phenotypes (France)
Status: NOT_YET_RECRUITING
Conditions: ARDS
Interventions: PROCEDURE: PEEP increase|PROCEDURE: PEEP decrease
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Hip Replacement on Lower Extremity Hemodynamics in Crowe IV Hip Dysplasia Patient
Status: UNKNOWN
Conditions: Hip Dysplasia
Interventions: PROCEDURE: total hip replacement with subtrochanteral osteotomy|PROCEDURE: total hip replacement with no osteotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The COVID-19 VaccinE Response and Co-Administration in Rheumatology Patients (COVER-CoAd)
Status: ACTIVE_NOT_RECRUITING
Conditions: Rheumatic Diseases
Interventions: BIOLOGICAL: Hepatitis A vaccine|BIOLOGICAL: Diphtheria, pertussis, and tetanus booster vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy Study of an Iontophoretic Patch Containing Lidocaine and Epinephrine for Venipuncture in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Local Anesthesia
Interventions: DEVICE: Iontophoretic Drug Delivery System with Lidocaine/Epinephrine|DEVICE: Iontophoretic Drug Delivery System with Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial of No Strings Intrauterine Device (IUD) Removal Techniques
Status: RECRUITING
Conditions: IUD Threads Not Visible|IUD Removal Complication
Interventions: PROCEDURE: IUD removal with no visible strings|DEVICE: Alligator forceps|DEVICE: Manual Vacuum Aspirator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Response Evaluation of Proton Therapy by PET-imaging in Squamous Cell Carcinoma Located in the Head and Neck
Status: TERMINATED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: RADIATION: Intensity Modulated Proton Therapy (IMPT) +/- Chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Community-based Occupational Therapy Intervention on Mental Health for People With Acquired Brain Injury
Status: UNKNOWN
Conditions: Acquired Brain Injury|Mental Health Issue
Interventions: BEHAVIORAL: Community-based Occupational Therapy|BEHAVIORAL: Standard community-based intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Efficacy of Intravenous Hyoscine-N-Butylbromide (HNB) in Abdominal Colic Associated With Acute Gastroenteritis
Status: UNKNOWN
Conditions: Abdominal Cramps
Interventions: DRUG: Hyoscine-N-Butylbromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Pressure Ulcers in Patients at High Risk of Developping Pressure Ulcers Using the Low-pressure Motorized Air Support Mattress With XTECH®25 Control Unit
Status: RECRUITING
Conditions: Pressure Ulcer
Interventions: DEVICE: Use of a powered low air pressure motorised therapeutic mattress that combines the motorised and static technologies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: High Ticagrelor Loading Dose in STEMI
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Ticagrelor 180mg|DRUG: Ticagrelor 270mg|DRUG: Ticagrelor 360mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VLA2001 Booster in Adult Participants After Priming With mRNA COVID-19 Vaccine and/or Natural SARS-CoV-2 Infection
Status: COMPLETED
Conditions: SARS-CoV-2 Infection
Interventions: BIOLOGICAL: VLA2001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Compare the Effects of Single Versus Repeated Intracoronary Application of Autologous Bone Marrow-derived Mononuclear Cells on Mortality in Patients With Chronic Post-infarction Heart Failure
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure
Interventions: BIOLOGICAL: intracoronary infusion of autologous bone marrow-derived cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalated Proton Beam Therapy or Photon Therapy for Esophageal Cancer
Status: WITHDRAWN
Conditions: Esophageal Cancer
Interventions: RADIATION: Proton Beam Therapy|RADIATION: Photon Radiation Therapy|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality in People With Persistent Postural-Perceptual Dizziness
Status: COMPLETED
Conditions: Vestibular Dizziness
Interventions: OTHER: Vestibular Rehabilitation Therapy (VRT)|OTHER: Virtual reality exercises|OTHER: Optokinetic Stimulation exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liposomal Daunorubicin and SU5416 in Treating Patients With Hematologic Cancer That Has Not Responded to Initial Therapy
Status: COMPLETED
Conditions: Chronic Myelomonocytic Leukemia|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Myeloid Leukemia|Refractory Anemia With Excess Blasts|Refractory Anemia With Excess Blasts in Transformation
Interventions: DRUG: liposomal daunorubicin citrate|DRUG: semaxanib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Myofascial Release Technique Applied to in Patients With Temporomandibular Dysfunction
Status: UNKNOWN
Conditions: Temporomandibular Joint Disorder|Low Back Pain
Interventions: OTHER: Myofascial Release Techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effect of Intraoperative Esmolol in Mastectomies
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Placebo group|DRUG: Esmolol group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of [11C]CPPC as a Clinical PET Radioligand Biomarker of Microglial Activation in ALS
Status: NOT_YET_RECRUITING
Conditions: ALS
Interventions: DRUG: [11C]CPPC PET ligand
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Lifestyle Management of CKD in Obese Diabetic Patients
Status: COMPLETED
Conditions: Obesity|Type 2 Diabetes|Chronic Kidney Disease (CKD)
Interventions: BEHAVIORAL: Social Cognitive Theory|OTHER: Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Recombinant Albumin Fusion Protein sEphB4-HSA in Treating Patients With Metastatic or Recurrent Solid Tumors
Status: TERMINATED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: OTHER: laboratory biomarker analysis|OTHER: pharmacological study|BIOLOGICAL: recombinant albumin fusion protein sEphB4-HSA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Fostamatinib Disodium/R935788 for the Treatment of Adult Refractory Immune Thrombocytopenic Purpura (ITP)
Status: COMPLETED
Conditions: Purpura, Thrombocytopenic, Idiopathic
Interventions: DRUG: Fostamatinib Disodium / R935788
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Loss-of-resistance Syringe Technique in Determining Endotracheal Cuff Pressure
Status: COMPLETED
Conditions: Endotracheal Tube Cuff Pressure|Loss of Resistance Syringe|Airway Edema|Pediatric Population
Interventions: PROCEDURE: Endotracheal tube cuff inflation with the loss of resistance syringe method
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Zinc Supplementation on Mortality and Hospitalizations in Children Aged 1 Months to 23 Months
Status: COMPLETED
Conditions: Morbidity|Mortality|Diarrhea|Pneumonia
Interventions: DRUG: Zinc and iron folic acid - Intervention|DRUG: Iron Folic Acid alone - Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: HPV DNA-Guided Radiotherapy De-intensification of Head and Neck Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Squamous Cell Carcinoma of the Oropharynx
Interventions: RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Study the Effect of Vitamin D Supplementation on Glucose and Insulin Metabolism in Centrally Obese Men
Status: COMPLETED
Conditions: Diabetes Mellitus, Non-Insulin-Dependent|Obesity
Interventions: DRUG: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Radiation Therapy vs. Observation Following Gemcitabine and Cisplatin for Inoperable Localized Liver Cancer
Status: TERMINATED
Conditions: Stage III Intrahepatic Cholangiocarcinoma|Stage IVA Intrahepatic Cholangiocarcinoma
Interventions: RADIATION: Image Guided Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy and Safety of Epoetin Beta (NeoRecormon®) in Anemic Participants With Breast Cancer Undergoing Chemotherapy
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Epoetin Beta
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of TAS-102(Suyuan) Combined With Bevacizumab as First-line Therapy in Patients With Advanced Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: Tas-102(Suyuan) combined with bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Galantamine Effects in Patients With Metabolic Syndrome
Status: COMPLETED
Conditions: Abdominal Obesity Metabolic Syndrome
Interventions: DRUG: Galantamine|DRUG: Placebo (for galantamine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Niraparib With Radiotherapy for Treatment of Metastatic Invasive Carcinoma of the Cervix
Status: TERMINATED
Conditions: Metastatic Carcinoma of the Cervix
Interventions: DRUG: Nirapaib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Find Out if Fezolinetant Helps Reduce Moderate to Severe Hot Flashes in Women Going Through Menopause - 2
Status: COMPLETED
Conditions: Hot Flashes
Interventions: DRUG: Fezolinetant|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Organ Preservation in Locally Advanced Rectal Cancer by Radiochemotherapy Followed by Consolidation Chemotherapy.
Status: UNKNOWN
Conditions: Rectal Cancer|Rectal Neoplasms|Rectal Cancer Stage II|Rectal Cancer Stage III
Interventions: RADIATION: Radiotherapy|DRUG: Chemotherapy|OTHER: Deep regional hyperthermia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating IPI-926 in Combination With Gemcitabine in Patients With Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: IPI-926 plus gemcitabine|DRUG: Placebo plus gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Evaluation of MK-1966 in Combination With SD-101 in Participants With Advanced Malignancies (MK-1966-001)
Status: TERMINATED
Conditions: Neoplasms, Advanced
Interventions: BIOLOGICAL: MK-1966|DRUG: SD-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Haplo / Allogeneic NKG2DL-targeting Chimeric Antigen Receptor-grafted γδ T Cells for Relapsed or Refractory Solid Tumour
Status: UNKNOWN
Conditions: Colorectal Cancer|Triple Negative Breast Cancer|Sarcoma|Nasopharyngeal Carcinoma|Prostate Cancer|Gastric Cancer
Interventions: BIOLOGICAL: Adoptive Cell Transfer of NKG2DL-targetting Chimeric Antigen Receptor-grafted Gamma Delta T cell
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Investigate the Treatment Benefit of Probiotic Lactobacillus Crispatus M247 in Women Undergoing Homologous Level 2 Assisted Reproductive Technology (ART) Procedures
Status: COMPLETED
Conditions: Fertility Issues
Interventions: DIETARY_SUPPLEMENT: Probiotic Lactobacillus crispatus M247
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic, Low Dose Erythropoetin Beta in Ischemic Cardiomyopathy
Status: COMPLETED
Conditions: Ischemic Cardiomyopathy
Interventions: DRUG: erythropoetin beta|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Control Study of Dermal Staples vs Subcuticular Sutures on Postoperative Scar After Thyroidectomy
Status: COMPLETED
Conditions: Thyroidectomy|Pain|Esthetic|Dermal Stapler
Interventions: DEVICE: INSORB|PROCEDURE: classic intradermal suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Newcastle Disease Virus (NDV) for Cancer Patients Resistant to Conventional Anti-cancer Modalities
Status: WITHDRAWN
Conditions: Metastatic Cancer|Newcastle Disease Virus (NDV)
Interventions: PROCEDURE: Newcastle Virus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D, C-reactive Protein and Insulin Resistance
Status: COMPLETED
Conditions: Diabetes|Low-intensity Chronic Inflammation|Insulin Resistance
Interventions: DRUG: cholecalciferol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cyst Fluid Glucose for On-site Diagnosis of Mucinous Pancreatic Cysts
Status: COMPLETED
Conditions: Pancreatic Cyst
Interventions: DEVICE: pancreatic cyst fluid glucose analysis using a bedside glucometer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Corticosteroid Reduction in COPD
Status: COMPLETED
Conditions: Lung Diseases, Obstructive|Blood Eosinophil Count|Glucocorticoids|COPD|Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Increased Fiber Diet Consumption on Outcomes of Subjects With Visceral Obesity
Status: UNKNOWN
Conditions: Visceral Obesity
Interventions: DIETARY_SUPPLEMENT: fruits, vegetables and/or whole grain high fiber rich diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: GRAVITAS-119: Itacitinib in Combination With Calcineurin Inhibitor-Based Interventions for the Prophylaxis of Graft-Versus Host Disease
Status: TERMINATED
Conditions: Hematologic Malignancies
Interventions: DRUG: Itacitinib|DRUG: Calcineurin inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of ELDOA and Mechanical Traction Technique on Pain and Disability in Patients With Lumbar Disc Herniation
Status: COMPLETED
Conditions: Lumbar Disc Herniation
Interventions: OTHER: ELDOA Technique|OTHER: Mechanical Lumbar Traction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Remote, Decentralized Opioid Use Disorder Study to Evaluate Patient Engagement With a Game-Based Digital Therapeutic
Status: COMPLETED
Conditions: Opioid-use Disorder
Interventions: DEVICE: reSET-O|DEVICE: PEAR-008
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cerebral Effects of Pulsed Radiofrequency on the Lumbar Dorsal Root Ganglion With Functional Magnetic Resonance Imaging.
Status: UNKNOWN
Conditions: Lumbar Radiculopathy|Chronic Disease
Interventions: DEVICE: Pulsed Radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fibromyalgia TENS in Physical Therapy Study (TIPS): an Embedded Pragmatic Clinical Trial
Status: RECRUITING
Conditions: Fibromyalgia
Interventions: DEVICE: Transcutaneous Electrical Nerve Stimulation (TENS) with PT|OTHER: PT only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sentinel Lymph Node Biopsy With or Without Para-Sentinel Lymph Node Dissection in Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: PROCEDURE: Patients receive SLNB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a New Formulation of Torasemide (Prolonged Release)on Myocardial Fibrosis in Patients With Heart Failure.
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: DRUG: Torasemide Prolonged Release|DRUG: Furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Wearable Device Intervention to Improve Sun Behaviors in Melanoma Survivors
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BEHAVIORAL: Shade + app with messaging|BEHAVIORAL: Shape + app without messaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics, Safety and Tolerability of Single Doses of BIIB033 (Opicinumab) Produced by 2 Manufacturing Processes
Status: COMPLETED
Conditions: Multiple Sclerosis|Acute Optic Neuritis
Interventions: DRUG: BIIB033 (opicinumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Open-label, Multi-center Phase Ⅳ Trial to Evaluate the Efficacy and Safety of Sequential Neoadjuvant Chemotherapy With Docetaxel(Monotaxel®) After Doxorubicin Plus Cyclophosphamide Combination Chemotherapy in Locally Advanced Breast Cancer
Status: COMPLETED
Conditions: Locally Advanced Breast Cancer
Interventions: DRUG: Neoadjuvant Chemotherapy with Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-Center,Evaluation of the Onset and Duration of Action of AC-170 0.24% Compared to Vehicle
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: AC-170 0.24%|DRUG: AC-170 0%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Block With Ropivacaine and Dexmedetomidine on Opioid Consumption After Lumar Spine Surgeries
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: OTHER: ESPB (regional Block)|DRUG: ropivacaine and dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Investigating the Microbiome and Volatile Organic Compound Profile of Children With Neuroblastoma
Status: UNKNOWN
Conditions: Microbial Colonization|Neuroblastoma|Children, Only
Interventions: DIAGNOSTIC_TEST: Initial fecal microbiome|DIAGNOSTIC_TEST: Initial fecal volatile organic compounds|DIAGNOSTIC_TEST: Initial breath volatile organic compounds|DIAGNOSTIC_TEST: Microbiome under chemotherapy|DIAGNOSTIC_TEST: Fecal volatile organic compounds under chemotherapy|DIAGNOSTIC_TEST: Breath volatile organic compounds under chemotherapy|DIAGNOSTIC_TEST: Final microbiome|DIAGNOSTIC_TEST: Final fecal volatile organic compounds|DIAGNOSTIC_TEST: Final breath volatile organic compounds
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Is the 3D-PANC MSP Model Superior to CT for Assessing Response to Neoadjuvant Treatment in PCA Patients?
Status: RECRUITING
Conditions: Adenocarcinoma of the Pancreas
Interventions: PROCEDURE: Three dimensional imaging technology (3D-PANC MSP model)|PROCEDURE: Computerized tomography group (conventional CT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Power Training in Older Multiple Sclerosis Patients
Status: RECRUITING
Conditions: Multiple Sclerosis|Sclerosis|Demyelinating Autoimmune Diseases, CNS|Autoimmune Diseases of the Nervous System|Demyelinating Diseases|Healthy Aging|Aging
Interventions: OTHER: Power training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of CD5 CAR Engineered IL15-Transduced Cord Blood-Derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapsed/Refractory Hematological Malignances
Status: RECRUITING
Conditions: Hematological Malignancy
Interventions: DRUG: Fludarabine Phosphate|DRUG: Cyclophosphamide|DRUG: CAR.5/IL15-transduced CB-NK cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iressa in the Treatment of Brain Metastases From Non Small Cell Lung Cancer
Status: TERMINATED
Conditions: Brain Neoplasms|Non Small Cell Lung Cancer
Interventions: DRUG: Iressa (Gefitinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety, Tolerability, Pulmonary Deposition, Pharmacokinetics and Pharmacodynamics of Ciprofloxacin Inhale in Japanese Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD, GOLD II-III)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Ciprofloxacin (Cipro InhaIe, BAYQ3939)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Placebo Controlled Study Using Lovaza as Treatment for Non-Alcoholic Fatty Liver Disease
Status: UNKNOWN
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: DRUG: Lovaza|DRUG: placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Asthma Research in Children and Adolescents
Status: ACTIVE_NOT_RECRUITING
Conditions: Persistent Asthma|Asthma in Children|Asthma Exacerbation
Interventions: DRUG: Inhaled Corticosteroids (ICs)|DRUG: Fixed-Dose Combination of Inhaled Corticosteroids and Long- Acting Beta-agonist (ICs/LABA)|DRUG: Other treatments|DRUG: Inhaler device|BEHAVIORAL: Regularly monitoring of the Inhalation technique through mobile app
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to go Back Into Records and Observe How People With Metastatic Renal Cell Carcinoma (mRCC) Who Received a Medicine Called Sunitinib Responded to This Medicine.
Status: COMPLETED
Conditions: Carcinoma, Renal Cell|Clear-cell Metastatic Renal Cell Carcinoma
Interventions: DRUG: Sunitinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Investigate the Safety and Efficacy of Ricolinostat
Status: COMPLETED
Conditions: Peripheral Nervous System Diseases
Interventions: DRUG: Ricolinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Tolerability and Safety of "Allergovac Poliplus" in Polysensitized Patients With Rhinitis or Allergic Rhinoconjunctivitis With or Without Asthma: A Study in Daily Clinical Practice
Status: COMPLETED
Conditions: Allergic Rhinitis|Rhinoconjunctivitis|Asthma
Interventions: BIOLOGICAL: Allergovac Poliplus
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Statins Evaluation in Coronary Procedures and Revascularization Trial
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of ASP5502 in Healthy Adults and Adults With Primary Sjögren's Syndrome
Status: RECRUITING
Conditions: Healthy Volunteers|Sjögren's Syndrome
Interventions: DRUG: ASP5502|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Tislelizumab (BGB-A317) in Combination With Chemotherapy as First Line Treatment in Participants With Advanced Esophageal Squamous Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma (ESCC)
Interventions: DRUG: Cisplatin|DRUG: Oxaliplatin|DRUG: Fluorouracil (5-FU)|DRUG: Capecitabine|DRUG: Paclitaxel|DRUG: Tislelizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Efficacy, Safety and Tolerability of the Fixed Dose Triple Combination CHF 5993 With the Fixed Dose Dual Combination CHF 1535 in Subjects With COPD
Status: RECRUITING
Conditions: COPD|COPD Exacerbation
Interventions: DRUG: Beclomethasone Dipropionate|DRUG: Glycopyrronium Bromide|DRUG: Formoterol Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Adipose Stem Cells and Platelet Rich Plasma Therapy for Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: BIOLOGICAL: Autologous adipose tissue stromal vascular fraction and platelet rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating Accelerated Learning in Tinnitus Participants Implanted With Vagus Nerve Stimulation
Status: WITHDRAWN
Conditions: VNS Implanted Tinnitus Patients
Interventions: DEVICE: Vagus Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: CREDE Study: Intraoperative Crede Manoeuver Compared to Preoperative Prolapse Reduction Stress Test to Predict Postoperative de Novo Stress Urinary Incontinence (PONSUI) at the Time of Pelvic Organ Prolapse (POP) Surgery
Status: RECRUITING
Conditions: Pelvic Organ Prolapse|de Novo Stress Urinary Incontinence|Stress Urinary Incontinence
Interventions: DIAGNOSTIC_TEST: Intraoperative Crede manoeuver|DIAGNOSTIC_TEST: Preoperative prolapse reduction cough stress test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Initial Increase in Cuff Pressure in Anterior Cervical Spinal Surgery
Status: COMPLETED
Conditions: Pressure Injury|Dysphonia|Dysphagia
Interventions: PROCEDURE: nasotracheal intubation|PROCEDURE: orotracheal intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CPG 7909 Injection in Melanoma
Status: COMPLETED
Conditions: Carcinoma, Melanoma
Interventions: DRUG: CPG 7909 Injection|DRUG: dacarbazine|DRUG: Chemotherapy|DRUG: CPG 7909 Injection|DRUG: CPG 7909 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Relationship Between Plantar Fascia and Achilles Tendon Thickness Asymmetry and Spatio-temporal Parameters of Gait
Status: NOT_YET_RECRUITING
Conditions: Achilles Tendon Thickness|Plantar Fascia Thickness|Spatio-temporal Parameteres of Gait
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Corchorus Olitorius Buccal Films for the Treatment of Recurrent Minor Aphthous Ulcerations
Status: COMPLETED
Conditions: Aphthous Ulcer Recurrent
Interventions: DIETARY_SUPPLEMENT: Corchorus Olitorius Buccal fast dissolving Films|DIETARY_SUPPLEMENT: plain mucoadhesive fast dissolving film
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Individualised Postprandial Glucose Responses in Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes|Diabetes Complications|Postprandial Hyperglycemia
Interventions: OTHER: Nutritional Interventional
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of V117957 in Overactive Bladder Syndrome
Status: COMPLETED
Conditions: Overactive Bladder Syndrome
Interventions: DRUG: V117957|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Emergent Microsurgical Intervention in Acute Stroke Patients After Mechanical Thrombectomy Failure Trial
Status: UNKNOWN
Conditions: Acute Stroke|Surgical Procedure
Interventions: PROCEDURE: Microsurgical intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: TRIAGE-CRT Telemonitoring in Patients With CHF and Indication of CRT-D
Status: COMPLETED
Conditions: Congestive Heart Failure|Cardiac Resynchronization Therapy
Interventions: DEVICE: Kronos LV-T, Lumax HF-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BioGlue or Vivostat in the Control of Air Leak in Thoracic Surgery
Status: COMPLETED
Conditions: Thoracic Surgery|Air Leak
Interventions: OTHER: Vivostat|OTHER: BioGlue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Alectinib Versus Pemetrexed or Docetaxel in Anaplastic Lymphoma Kinase (ALK)-Positive Advanced Non-Small Cell Lung Cancer (NSCLC) Participants Previously Treated With Platinum-Based Chemotherapy and Crizotinib
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Alectinib|DRUG: Docetaxel|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study for Optically Guided Radiofrequency Ablation Catheter
Status: TERMINATED
Conditions: Atrial Fibrillation|Atrial Flutter
Interventions: DEVICE: AblaView® Ablation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Oral Acetyl-L-Carnitine Therapy Reduces Fatigue In Hepatic Encephalopathy
Status: COMPLETED
Conditions: Hepatic Encephalopathy
Interventions: DIETARY_SUPPLEMENT: ACETYL-L-CARNITINE|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Efficacy and Safety of Substitution of Glucocorticoid for BDB-001 Injection in Patients With Anti-neutrophil Cytoplasmic Antibody(ANCA)-Associated Vasculitis
Status: RECRUITING
Conditions: ANCA-associated Vasculitis
Interventions: DRUG: BDB-001 injection|DRUG: Cyclophosphamide|DRUG: Glucocorticoids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lamotrigine for Symptoms of Geriatric Bipolar Depression
Status: COMPLETED
Conditions: Bipolar Disorder|Depression, Bipolar
Interventions: DRUG: Lamotrigine regular tablet formulation|DRUG: Lamotrigine novel formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-time Tele-monitoring Versus Routine Monitoring of Breast Cancer Patients Receiving Adjuvant Systemic Therapy
Status: UNKNOWN
Conditions: Breast Cancer Female
Interventions: OTHER: Tele-monitoring through mobile application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An Inpatient Study of ALLN-346 (Engineered Urate Oxidase) in Hyperuricemic Subjects (Study 201)
Status: COMPLETED
Conditions: Hyperuricemia|Gout|Chronic Kidney Diseases
Interventions: DRUG: ALLN-346|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficiency of Single Buccal Infiltration Versus Buccal and Intrapapillary Infiltration
Status: UNKNOWN
Conditions: Anesthesia, Local
Interventions: OTHER: Single buccal infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Human Plasma-derived C1-esterase Inhibitor as add-on to Standard of Care for the Treatment of Refractory Antibody Mediated Rejection (AMR) in Adult Renal Transplant Recipients
Status: TERMINATED
Conditions: Antibody-mediated Rejection
Interventions: DRUG: C1-esterase inhibitor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy, Safety, and Pharmacokinetics of FCN-437c in Combination With Fulvestrant or Letrozole+Goserelin
Status: UNKNOWN
Conditions: Breast Neoplasms
Interventions: DRUG: FCN-437c+Fulvestrant|DRUG: FCN-437c+Letrozole+Goserelin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Class III Malocclusion Using Modified Fixed Mandibular Retractor Appliance
Status: COMPLETED
Conditions: Malocclusion, Angle Class III
Interventions: DEVICE: Modified Fixed Mandibular Retractor Appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Olaparib With Concomitant Radiotherapy in Locally Advanced/Unresectable Soft-tissue Sarcoma
Status: COMPLETED
Conditions: Soft-tissue Sarcoma
Interventions: DRUG: Olaparib|RADIATION: Concomitant Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plasma Glucose Kinetics and Cereal Product Content in Slowly Digestible Starch (SDS) in Healthy Volunteers
Status: COMPLETED
Conditions: Blood Glucose Kinetics
Interventions: OTHER: Nutrition intervention with cereal products
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Telbivudine Versus Lamivudine in Chinese Adults With Compensated Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: telbivudine|DRUG: lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin Injections by Ultrasounds Guidance and Stretching Exercise in Spastic Toe Clawing
Status: COMPLETED
Conditions: Cerebrovascular Accident
Interventions: DRUG: Botulinum Toxin Type A|OTHER: Stretching exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment for Patients With Osteoarthritis (OA)
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Systemic AMG 108|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Jeju Red Horsehead Fish-based, High Protein Diet on Satiety and Incretin Hormones in Diabetes Patients
Status: COMPLETED
Conditions: Diabetes Mellitus|Obesity
Interventions: DIETARY_SUPPLEMENT: High-protein diet|DIETARY_SUPPLEMENT: Standard diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Robot-assisted Gait Training on Gait Automaticity in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease|Gait Disorders, Neurologic
Interventions: DEVICE: Robot-assisted gait training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Impact of Intraoperative Blood Pressure Management on Postoperative Outcomes (MAP-ALIVE)
Status: WITHDRAWN
Conditions: Death|Postoperative Complications|Myocardial Infarction|Stroke|Renal Failure
Interventions: OTHER: FACE quality improvement initiative (see below)|OTHER: Pre-quality improvement initiative
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Personalized Video-based Exercise Program for Fall Prevention in Frail and Pre-frail Older Adult
Status: RECRUITING
Conditions: Fall Injury|Frailty|Old Age; Atrophy|Age-Related Atrophy|Age-Related Sarcopenia
Interventions: OTHER: SAFE program (exercise intervention)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: First-in-human Study With Ascending Single Intra-articular Doses of GZ389988 in Patients With Painful Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: placebo|DRUG: GZ389988
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sofosbuvir+Ribavirin in Genotype 2 HCV-infected U.S. Veterans With Cirrhosis
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: Sofosbuvir|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PTC299 in Treating Patients With HIV-Related Kaposi Sarcoma
Status: TERMINATED
Conditions: Kaposi's Sarcoma
Interventions: DRUG: VEGF inhibitor PTC299|GENETIC: gene expression analysis|GENETIC: polymerase chain reaction|GENETIC: protein expression analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|OTHER: pharmacological study|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Action Observation Therapy With and Without Acoustic Stimulation in Post Stroke Gait and Balance
Status: RECRUITING
Conditions: Stroke
Interventions: OTHER: Action Observation Therapy with Rhythmic acoustic stimulation|OTHER: Action Observation Therapy without Rhythmic acoustic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Building Capacity and Promoting Smoking Cessation in the Community Via "Quit to Win" Contest 2019
Status: UNKNOWN
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Initial phase: personalized instant messaging (PIM)|BEHAVIORAL: Second phase: optional cocktail interventions (OCI)|BEHAVIORAL: Initial phase: regular instant messaging (RIM)|BEHAVIORAL: Second phase: personalized instant messaging (PIM)|BEHAVIORAL: AWARD advice|BEHAVIORAL: Warning leaflet|BEHAVIORAL: Referral card|BEHAVIORAL: COSH booklet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Prolongation of the Interval Between Prothrombin Time Tests in Stable Patients II
Status: WITHDRAWN
Conditions: Atrial Fibrillation|Valvular Heart Disease|Deep Vein Thrombosis|Pulmonary Embolism|Peripheral Arterial Disease
Interventions: OTHER: Prolonged interval between PT testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study Evaluating Two New Encorafenib Formulations
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Encorafenib capsule formulation (CAP)|DRUG: Encorafenib first formulation|DRUG: Encorafenib second formulation|DRUG: Rabeprazole tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Characterization by Clinimetric Indicators of Chronic Low Back Pain Subjects Versus Healed Patients
Status: COMPLETED
Conditions: Chronic Low Back Pain|Postural Low Back Pain
Interventions: OTHER: Control. no therapeutic program|OTHER: Experimental. Therapeutic program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Active Release Technique and Instrument Assisted Soft Tissue Mobilization in Patients With Migraine
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: OTHER: Active Release Technique|OTHER: Instrument Assisted Soft Tissue Mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing the Natriuretic Peptide System in HFpEF
Status: ENROLLING_BY_INVITATION
Conditions: Heart Failure With Preserved Ejection Fraction|Chronic Kidney Diseases
Interventions: DRUG: MANP|DRUG: Sacubitril/Valsartan|DRUG: Oral Placebo|DRUG: Injection Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT