pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Myofunctional Therapy in Open Bite - RCT
Status: NOT_YET_RECRUITING
Conditions: Open Bite
Interventions: PROCEDURE: Myofunctional therapy (+)|PROCEDURE: Myofunctional therapy (-)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Drug-drug Interaction of JMKX001899 in Healthy Subjects
Status: NOT_YET_RECRUITING
Conditions: Solid Tumor, Adult
Interventions: DRUG: JMKX001899|DRUG: Itraconazole|DRUG: Midazolam|DRUG: Rifampin|DRUG: dextromethorphan|DRUG: Rosuvastatin|DRUG: digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Rice Bran and Cooked Navy Beans on Cholesterol Levels in Healthy Children
Status: COMPLETED
Conditions: Hyperlipidemias
Interventions: DIETARY_SUPPLEMENT: Bean powder|DIETARY_SUPPLEMENT: Rice bran|DIETARY_SUPPLEMENT: Control arm|DIETARY_SUPPLEMENT: Bean powder and rice bran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Safety & Tolerability of Long-term Use of Patented Transdermal Patches in Healthy Adults.
Status: COMPLETED
Conditions: Vitamin D
Interventions: OTHER: To Better Days Large Patch|OTHER: To Better Days Small Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cetuximab in Combination With S-1 and Cisplatin in Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: Cetuximab|DRUG: Cisplatin|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of Alemtuzumab in Patients With Relapsed Ovarian/Primary Peritoneal Cancer.
Status: TERMINATED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Cancer
Interventions: DRUG: Alemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrated Treatment for Adolescents With ADHD
Status: COMPLETED
Conditions: ADHD|Substance Use Disorders
Interventions: BEHAVIORAL: Medication Integration Protocol (MIP)|BEHAVIORAL: Changing Academic Support in the Home for Adolescents with ADHD (CASH-AA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intravesical Instillation of Hyaluronic Acid to Decrease Incidence of Urinary Tract Infection
Status: WITHDRAWN
Conditions: Urinary Tract Infection
Interventions: DRUG: Hyaluronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bridging Study With GSK239512 In Patients With Mild To Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: GSK239512|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Alemtuzumab and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV T-Cell Non-Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: BIOLOGICAL: alemtuzumab|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: prednisone|DRUG: vincristine sulfate|OTHER: flow cytometry|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Necessity of Time Interval Between Instillation of Two Glaucoma Eye Drops
Status: UNKNOWN
Conditions: Glaucoma|Glaucoma; Drugs
Interventions: BEHAVIORAL: 5 minute interval between regular glaucoma drops - Long term|BEHAVIORAL: no interval between regular glaucoma drops - Long term|DRUG: IOP reduction of Brimonidine and Timolol with time interval|DRUG: IOP reduction of Brimonidine and Timolol no time interval
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Pharmacologic Action of a GPR119 Agonist on Glucagon Counter-regulation During Insulin-induced Hypoglycemia in Type 1 Diabetes Mellitus
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Placebo|DRUG: Study Medication (MBX-2982)|OTHER: No medication for this group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of Salt-Water Solution to Improve Symptoms in Concussion
Status: COMPLETED
Conditions: Brain Concussion|Post-Concussion Symptoms
Interventions: DRUG: 3% Hypertonic saline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety, Tolerability, and PK of EP547 in Healthy Subjects and Subjects With Cholestatic or Uremic Pruritus
Status: COMPLETED
Conditions: Pruritus|Cholestasis|Kidney Failure
Interventions: DRUG: EP547|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DARWIN Study: A Randomization/Withdrawal Efficacy Study of Dexloxiglumide in Constipation-Predominant Irritable Bowel Syndrome (C-IBS)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: dexloxiglumide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Vertical GBR LPRF Block vs. Autogenous Bone With DBBM
Status: COMPLETED
Conditions: Alveolar Bone Resorption
Interventions: PROCEDURE: guided bone regeneration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lentiviral (LV) Gene Therapy for Adenosine Deaminase (ADA) Deficiency
Status: COMPLETED
Conditions: Adenosine Deaminase Deficiency|Severe Combined Immunodeficiencies (SCID)
Interventions: GENETIC: Infusion of autologous EFS-ADA LV CD34+ cells|OTHER: Haematopoietic Stem Cell Transplantation (HSCT)|DRUG: Busulfan|DRUG: Peg-Ada
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Evaluation and Effect of Food Supplement Containing Dietary Fiber From Cassava on the Alterations of Physiological Parameters in Overweight Female Volunteers
Status: COMPLETED
Conditions: Overweight
Interventions: DIETARY_SUPPLEMENT: Cassava dietary fiber capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Terlipressin Given As I.V. Boluses Versus Terlipressin Given As Continuous Intravenous Infusion In Patients With Cirrhosis And Type 1 Hepatorenal Syndrome
Status: UNKNOWN
Conditions: Cirrhosis|Type 1 Hepatorenal Syndrome
Interventions: DRUG: terlipressin given by intravenous boluses and albumin|DRUG: terlipressin given by continuous intravenous infusion and albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1, Dose Escalation Study to Evaluate of Safety, Pharmacokinetics and Pharmacodynamics of Liposomal Bupivacaine 13.3 Administered Via a Single Intrathecal Injection to Healthy Volunteers
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: Liposomal Bupivacaine 13.3|DRUG: Bupivacaine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Microvascular Blood Flow in Sickle Cell Anemia
Status: COMPLETED
Conditions: Sickle Cell Disease|Sickle Cell Anemia
Interventions: DRUG: regadenoson infusion with contrast-enhanced ultrasound|PROCEDURE: contrast-enhanced ultrasound|PROCEDURE: contrast-enhanced ultrasound|PROCEDURE: contrast-enhanced ultrasound|PROCEDURE: contrast-enhanced ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of TAK-559 in Treating Subjects With Type 2 Diabetes Mellitus
Status: TERMINATED
Conditions: Diabetes Mellitus
Interventions: DRUG: TAK-559 and insulin|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of TG-1701, an Irreversible Bruton's Tyrosine Kinase Inhibitor, in Patients With B-Cell Malignancies
Status: TERMINATED
Conditions: Non Hodgkin Lymphoma|Chronic Lymphocytic Leukemia
Interventions: DRUG: TG-1701|DRUG: Umbralisib|BIOLOGICAL: Ublituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Sodium Fusidate (CEM-102) Versus Oral Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections
Status: COMPLETED
Conditions: Acute Bacterial Skin and Skin Structure Infections
Interventions: DRUG: sodium fusidate|DRUG: linezolid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyperpolarized Xenon MRI for Assessment of Pulmonary Function in Lung Transplant
Status: COMPLETED
Conditions: Pulmonary Surgical Procedures
Interventions: DRUG: 129Xe MRI|DRUG: 133XE scintigraphy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Flexible Ureteroscopy With Tip-bendable Suction Ureteral Access Sheath Versus Mini-Percutaneous Nephrolithotomy for Treatment of 2-3cm Renal Stones
Status: NOT_YET_RECRUITING
Conditions: Urolithiasis|Kidney Stone
Interventions: PROCEDURE: f-URS|PROCEDURE: mini-PCNL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/Ib Study of MEK162, a MEK Inhibitor, in Combination With Carboplatin and Pemetrexed in Patients With Non-squamous Carcinoma of the Lung
Status: COMPLETED
Conditions: Lungcancer
Interventions: DRUG: Binimetinib|DRUG: Pemetrexed|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Protein and Exercise Therapy Plus Nocturnal Enteral Feeding in Juvenile-onset Pompe Disease
Status: WITHDRAWN
Conditions: Glycogen Storage Disease Type II
Interventions: OTHER: High Protein and Exercise Therapy along-with Nocturnal Enteral Feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vemurafenib and TIL Therapy for Metastatic Melanoma
Status: COMPLETED
Conditions: Metastatic Melanoma
Interventions: DRUG: Vemurafenib|DRUG: Lymphodepleting chemotherapy|DRUG: TIL infusion|DRUG: Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiologic Results of One-Stage Bilateral TKR - One Surgeon Sequential vs. Two Surgeon Simultaneous: A Randomized Controlled Study
Status: UNKNOWN
Conditions: Gonarthrosis; Primary
Interventions: PROCEDURE: Simultaneous bilateral total knee arthroplasty|PROCEDURE: Sequenced bilateral TKA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Preservon-Treated Bone Implants for Cervical Fusion in the Treatment of Cervical Radiculopathy or Myelopathy
Status: COMPLETED
Conditions: Cervical Radiculopathy|Myelopathy
Interventions: PROCEDURE: Anterior Cervical Discectomy and Fusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combretastatin A4 Phosphate in Patients With Neovascular Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Combretastatin A4 Phosphate|Age-related Macular Degeneration|AMD|CNV|Choroidal Neovascularization
Interventions: DRUG: Combretastatin A-4 phosphate|DRUG: Combretastatin A-4 Phosphate|DRUG: Combretastatin A-4 Phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability Study of APL-130277 for the Acute Treatment of OFF Episodes in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease, Off Episodes
Interventions: DRUG: APL-130277|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Aspergillus Fumigatus (a Fungal Infection) in Patients With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ondansetron Plus Dexamethasone With or Without Metoclopramide as Antiemetic Prophylaxis After Receiving Cisplatin
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: metoclopramide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study to Estimate MTD, DLTs and Pharmacokinetics After a Single Intracranial Dose of SI-053 as an add-on to the Current Standard of Care, in Adult Patients With Newly Diagnosed GBM
Status: NOT_YET_RECRUITING
Conditions: Newly Diagnosed Glioblastoma
Interventions: DRUG: SI-053
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SJG-136 in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: SJG-136|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Cortical Response to Noxious and Auditory Stimuli Using Near Infrared Spectroscopy in Subjects Under General Anesthesia
Status: UNKNOWN
Conditions: Anesthesia|Pain
Interventions: DRUG: Remifentanil|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Bevacizumab With or Without Trebananib in Treating Patients With Recurrent Brain Tumors
Status: COMPLETED
Conditions: Giant Cell Glioblastoma|Glioblastoma|Gliosarcoma|Oligodendroglioma|Recurrent Brain Neoplasm|Recurrent Glioblastoma
Interventions: BIOLOGICAL: Bevacizumab|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|OTHER: Placebo Administration|BIOLOGICAL: Trebananib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2a Study on Allogeneic Osteoblastic Cells Implantation in Delayed-Union Fractures
Status: COMPLETED
Conditions: Long Bone Delayed-Union Fracture
Interventions: DRUG: ALLOB® implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-FSPG PET/MRI or PET/CT Imaging of Cardiac Sarcoidosis or Inflammation
Status: TERMINATED
Conditions: Cardiac Sarcoidosis|Myocardial Inflammation
Interventions: DRUG: 18F-FSPG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Bexxar <Tositumomab> Combined With External Beam Radiation Therapy
Status: TERMINATED
Conditions: Lymphoma, Non-Hodgkin
Interventions: DRUG: Bexxar (tositumomab)|PROCEDURE: External beam radiotherapy (XRT)|DRUG: Potassium Iodide (KI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liver Cancer Immunotherapy: Placebo-controlled Clinical Trial of Hepcortespenlisimut-L
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma|HCC|Liver Cancer
Interventions: BIOLOGICAL: hepcortespenlisimut-L|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Gemcabene on the Pharmacokinetics of Simvastatin in Healthy Volunteers
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Gemcabene 900 mg|DRUG: Simvastatin 80 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Revlimid With Doxil and Avastin for Patients With Platinum Resistant Ovarian Cancer
Status: TERMINATED
Conditions: Ovarian Cancer|Epithelial Ovarian Cancer|Fallopian Tube Carcinoma|Primary Peritoneal Carcinoma
Interventions: DRUG: Lenalidomide, Liposomal Doxorubicin, Bevacizumab|DRUG: Revlimid, Doxil, Avastin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stimulating Language in Subacute StrokE
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: A-tDCS (1 mA)|BEHAVIORAL: SALT|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Inhaled Ampion in Adults With Respiratory Distress Due to COVID-19
Status: TERMINATED
Conditions: Covid19
Interventions: BIOLOGICAL: Ampion|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple Dose Safety and Efficacy of LKA651 in Patients With Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: LKA651|DRUG: Lucentis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of 4-7-8 Breathıng Technıque on Shoulder Paın and Respıratory Functıon Tests After Laparoscopıc Cholesectectomy
Status: NOT_YET_RECRUITING
Conditions: Laparoscopic Cholecystectomy|Breathing Exercise|Pulmonary Function Test|Shoulder Pain|Surgical Nursing|4-7-8 Breathing Technique
Interventions: OTHER: 4-7-8 Breathing Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigation of Three Contraceptive Hormone Patches in Regard to Inhibition of Ovulation Following Application Over 3 Treatment Cycles in Healthy, Young Women.
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Gestodene/EE Patch (BAY86-5016)|DRUG: Gestodene/EE Patch (BAY86-5016)|DRUG: Gestodene/EE Patch (BAY86-5016)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Passive Leg Raise Induced Stroke Volume Changes in Elderly Prior to Elective Surgery Measured by LiDCOplusTM
Status: COMPLETED
Conditions: Stroke Volume|Cardiovascular System|Fluid Therapy
Interventions: OTHER: Passive leg raise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Inhibition of Rho Kinase (ROCK) With Fasudil as Disease-modifying Treatment for ALS
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Fasudil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 5 Fraction Stereotactic Radiosurgery With Temozolomide for Glioblastoma Multiforme
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of a Periodic Repetitive Transcranial Magenetic Stimulation in Parkinson Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Transcranial Magnetic Stimulation|Parkinson's Disease
Interventions: OTHER: transcranial magnetic stimulation|DRUG: Pharmacotherapy（antiparkinsonian drugs）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ofatumumab for High-Risk Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of Antihemophilic Factor/Von Willebrand Factor Complex in Surgical Subjects With Von Willebrand Disease (vWD)
Status: COMPLETED
Conditions: Von Willebrand Disease|Blood Coagulation Disorders|Blood Platelet Disorders|Hematologic Disease
Interventions: DRUG: Blood coagulation Factor VIII and vWF, human
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nursing Management of Irritable Bowel Syndrome (IBS) 2008
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: BEHAVIORAL: Usual Care (Control Group)|BEHAVIORAL: Comprehensive Self-Management (CSM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Haploidentical Hematopoietic Cell Transplantation for Children With Hematologic Malignancies and Myelodysplasia
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelodysplasia|Hematologic Malignancy
Interventions: DEVICE: CliniMACS® TCRαβ/CD19 Combined Depletion System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASC47 in Healthy Subjects
Status: NOT_YET_RECRUITING
Conditions: NASH
Interventions: DRUG: ASC47|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Patients With Chronic Hepatitis B With Hepatitis B Immunoglobulins
Status: RECRUITING
Conditions: Chronic Hepatitis B
Interventions: DRUG: Human hepatitis B Immunoglobulin (Hepatect®CP/Zutectra®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acceptability and Feasibility of Cognitive Behavioral Therapy for Treatment-Seeking (CBT-TS) With Deaf Individuals
Status: COMPLETED
Conditions: Mental Health Issue|Alcohol Use Disorder|Depression|Anxiety|Insomnia|Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Treatment Seeking (CBT-TS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Etanercept and Methotrexate in Combination or as Monotherapy in Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Etanercept|DRUG: Methotrexate|DRUG: Placebo to Etanercept|DRUG: Placebo to Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab With Chemotherapy for Poorly Chemo-responsive Thyroid and Salivary Gland Tumors
Status: SUSPENDED
Conditions: Thyroid Cancer|Salivary Gland Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnosis and Treatment of Sleep-Disordered Breathing in the Homes of Patients With Transient Ischemic Attack
Status: COMPLETED
Conditions: Transient Ischemic Attack|Sleep Apnea
Interventions: PROCEDURE: auto-titrating continuous positive airway pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: E2007 Given as Adjunctive Therapy in Patients With Refractory Partial Seizures
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: E2007 (perampanel)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Combined Decompressive Spine Radiosurgery and Pembrolizumab
Status: RECRUITING
Conditions: Epidural Spinal Tumors|Cancer
Interventions: DRUG: Pembrolizumab|RADIATION: Stereotactic Body Radiation Therapy|OTHER: Blood draws
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety of Aceneuramic Acid Extended Release (Ace-ER; UX001) Tablets in Glucosamine (UDP-N-acetyl)-2-Epimerase (GNE) Myopathy (GNEM) (Also Known as Hereditary Inclusion Body Myopathy [HIBM]) Patients With Severe Ambulatory Impairment
Status: TERMINATED
Conditions: Hereditary Inclusion Body Myopathy|Distal Myopathy With Rimmed Vacuoles|Distal Myopathy, Nonaka Type|GNE Myopathy|Quadriceps Sparing Myopathy|Inclusion Body Myopathy 2
Interventions: DRUG: Aceneuramic Acid Extended-Release
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Confidence Study of CCR2 Antagonist (BMS-741672) in Insulin Resistance
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: CCR2 Antagonist|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Long Acting Bronchodilators on CARDiac Autonomic Control in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Indacaterol|DRUG: Glycopyrronium|DRUG: Tiotropium|DRUG: Placebo|PROCEDURE: photoplethysmography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety & Efficacy Study of Quetiapine Fumarate (SEROQUEL®) vs. Placebo and Active Control in Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Quetiapine fumarate|DRUG: Duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Benefit of a Flash Dose of Corticosteroids in Digestive Surgical Oncology: a Randomized, Double Blind, Placebo-controlled Trial
Status: RECRUITING
Conditions: Elective Surgery for Any Digestive Cancer
Interventions: DRUG: Injection of methylprednisolone|DRUG: Injection of sodium chloride|BIOLOGICAL: Blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Is Univalving or Bivalving of Long Arm Casts for Forearm Fractures Necessary?
Status: COMPLETED
Conditions: Fracture of Shaft of Radius and/or Ulna|Metaphyseal Fracture of Bone of Upper Limb|Fracture of Upper Limb, Level Unspecified
Interventions: PROCEDURE: No Split Cast of forearm fractures|PROCEDURE: Univalve Split Cast of forearm fractures|PROCEDURE: Bivalve Split Cast of forearm fractures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incidence of Post-Operative Pain After Single Visit Root Canal Treatment in Necrotic Teeth Using Two Different Rotary Systems (Protaper Nex t& Neolix File)
Status: UNKNOWN
Conditions: Necrotic Pulp
Interventions: DEVICE: neolix file
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel Eluting Balloon in St Elevation Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DEVICE: Bare metal Stent plus Paclitaxel Balloon|DEVICE: Bare metal Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: HER3-DXd in Breast Cancer and NSCLC Brain Metastases and Solid Tumor Leptomeningeal Disease
Status: RECRUITING
Conditions: Metastatic Breast Cancer|Advanced Non-Small Cell Squamous Lung Cancer|Solid Tumor, Adult
Interventions: DRUG: Patritumab deruxtecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketofol Versus Fentofol for Procedural Sedation in the Pediatric Emergency Department
Status: COMPLETED
Conditions: Emergency Department Procedural Sedation|Fracture Reduction
Interventions: DRUG: Ketofol|DRUG: Fentofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intensive Unimanual (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegia
Status: COMPLETED
Conditions: Cerebral Palsy|Hemiplegia|Children
Interventions: OTHER: Constraint-induced Movement Therapy|OTHER: Hand-arm Bimanual Intensive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Pentoxifylline on Cognitive Impairment After Ischemic Stroke
Status: RECRUITING
Conditions: Cognitive Impairment
Interventions: DRUG: Pentoxifylline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Understanding Effects of Folic Acid on the Methylosome and Transcriptome of Women With Spina Bifida Affected Pregnancies
Status: RECRUITING
Conditions: Pregnancy; Spina Bifida, Fetal|Environmental Exposure
Interventions: DIETARY_SUPPLEMENT: Folic Acid Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Randomized Controlled Trial of Metacognitive Therapy and EMDR for Posttraumatic Stress Disorder
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Metacognitive therapy|BEHAVIORAL: EMDR|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Impact of Group Antenatal Care on IPTp Uptake in Tanzania
Status: TERMINATED
Conditions: Malaria|Malaria in Pregnancy
Interventions: OTHER: Group antenatal care (GANC)|OTHER: Standard antenatal care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Speed of Premolar Extraction Space Closure: Healed vs Recent Extraction Site
Status: COMPLETED
Conditions: Orthodontic Appliance
Interventions: DEVICE: Space closure into old extraction space|DEVICE: Space closure into recent extraction space
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Controlled Clinical Study of Rituximab in Treatment of Primary IgA Nephropathy
Status: ACTIVE_NOT_RECRUITING
Conditions: IgA Nephropathy
Interventions: DRUG: rituximab group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Standard Vs Adjusted Dosing of Piperacillin/Tazobactam in Acute Renal Failure and Septic Shock
Status: TERMINATED
Conditions: Septic Shock|Acute Renal Failure
Interventions: DRUG: Piperacillin/Tazobactam|DRUG: Piperacillin/Tazobactam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Perfenidone in Type 2 Diabetic Patients With Diabetic Neuropathy
Status: RECRUITING
Conditions: Diabetic Nephropathies|Type 2 Diabetes
Interventions: DRUG: Pirfenidone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Fibrinolysis in Patients With an Indwelling Pleural Catheter for Multi-loculated Malignant Pleural Effusion.
Status: WITHDRAWN
Conditions: Pleural Effusion|Cancer, Lung
Interventions: DRUG: tPA standard dosage|DRUG: tPA low dosage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Association of Different Doses of Clonidine in Caudal Epidural Anesthesia for Hypospadias Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Clonidine 1 mcg/Kg|DRUG: Clonidine 2 mcg/ Kg|DRUG: Clonidine 3 mcg/ Kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CSD190401: A Study to Assess Elements of Abuse Liability for Nicotine-containing Pouch Tobacco Products
Status: COMPLETED
Conditions: Smoking|Smoking Behaviors|Tobacco Use|Tobacco Smoking
Interventions: OTHER: Product A|OTHER: Product B|OTHER: Product C|OTHER: Product D|OTHER: Product E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Transcranial Doppler Vasoconstrictor Vasoreactivity During General Anesthesia in Hypertensive Patients
Status: WITHDRAWN
Conditions: Hypertensive Disease|Elderly|Vasopressors|General Anesthesia
Interventions: OTHER: Transcranial Doppler (DTC)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Gadobutrol and Gadobenate Dimeglumin for Delayed Enhancement Cardiac MRI
Status: COMPLETED
Conditions: Subacute/Chronic Myocardial Infarction
Interventions: OTHER: Gadovist® (Gadobutrol), Multihance® (Gadobenate dimeglumin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)
Status: RECRUITING
Conditions: Frontotemporal Dementia|FTD|FTD-GRN|Dementia, Frontotemporal
Interventions: PROCEDURE: Intrathalamic AAV.PGRN administration|GENETIC: Intrathalamic AVB-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of the Change in Liver Enzymes After General or Spinal Anesthetic Techniques in Patients With Preoperatively Elevated Liver Enzymes.
Status: COMPLETED
Conditions: Liver Enzymes After General or Spinal Anesthetic Techniques|In Patients With Preoperatively Elevated Liver Enzymes
Interventions: PROCEDURE: General anesthesia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults
Status: COMPLETED
Conditions: Epilepsy|Lennox-Gastaut Syndrome
Interventions: DRUG: GWP42003-P 20 mg/kg/day Dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study With Cis-UCA Ophthalmic Solutions in Subjects With Dry Eye
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: cis-UCA ophthalmic solution 1.0%|DRUG: cis-UCA ophthalmic solution 2.5%|DRUG: Placebo ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: How Does Basic Body Awareness Therapy Affect Pain Coping Strategies in Postmenopausal Women?
Status: RECRUITING
Conditions: Low Back Pain|Neck Pain|Menopause
Interventions: OTHER: Therapeutic Exercise Group|OTHER: Therapeutic Exercise+Basic Body Awareness Therapy Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Tolerability Associated With PPD10558 Versus Atorvastatin in Patients Previously Intolerant to Statins Due to Statin-associated Myalgia (SAM)
Status: COMPLETED
Conditions: Myalgia|Hypercholesterolemia|Hyperlipidemia
Interventions: DRUG: PPD10558|DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Female Sexual Functions With Progestogen-only Contraception
Status: COMPLETED
Conditions: Female Sexual Function
Interventions: DRUG: Depot Medroxyprogesterone Acetate 150 mg|DRUG: Implanon( 68 mg etonogestrel implant)|DRUG: Cerazette pills (75 micrograms desogestrel)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacologic Effects of Darifenacin and Tolterodine on Cardiovascular Parameters in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Darifenacin|DRUG: Tolterodine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Oral Probiotic on the Vaginal Flora and Microenvironment Alteration in the Vaginosis Infection Women
Status: RECRUITING
Conditions: Probiotic, Human Papillomavirus Infection, Pap Smear, Microbiome
Interventions: DIETARY_SUPPLEMENT: probiotic:Lactobacillus crispatus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Investigation to Assess the Performance of Natural Rubber Latex Condoms in Couples
Status: COMPLETED
Conditions: Control of Pregnancy|Prevention of Sexually Transmitted Infections
Interventions: DEVICE: NRL Condom
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effectiveness of Using E-Cigarettes for Smoking Cessation and Decreasing Risk of Diseases Among Heavy Smokers
Status: WITHDRAWN
Conditions: Smoking Cessation
Interventions: COMBINATION_PRODUCT: Electronic cigarettes + Health Counselling|OTHER: Health Counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Low-grade Glioma
Interventions: DEVICE: ReMind iPad app|DEVICE: Healthy SMS texting|BEHAVIORAL: In-person cognitive rehabilitation|BEHAVIORAL: Telehealth cognitive rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Vitamin B-6 Status on Homocysteine, Oxidative Stress, One-carbon Metabolism and Methylation: Cross-section, Case-control, Intervention and Follow-up Studies in Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: Vitamin C|DIETARY_SUPPLEMENT: Vitamin B6|DIETARY_SUPPLEMENT: Folic acid|DIETARY_SUPPLEMENT: Vitamin B6 plus folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Utility of Lung Ultrasound in the Estimation of Extravascular Lung Water in Pediatric Population
Status: COMPLETED
Conditions: Pulmonary Congestion|Congenital Heart Disease|Post-Op Complication
Interventions: DIAGNOSTIC_TEST: Lung ultrasound and EVLW measurement by transpulmonary thermodilution.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Mother's Supplementation Omega-3 in the Dynamics of Fetal Ductus Arteriosus: a Randomized Clinical Trial.
Status: UNKNOWN
Conditions: Pregnancy
Interventions: DIETARY_SUPPLEMENT: Omega 3|DIETARY_SUPPLEMENT: Soy Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Trial Comparing Efficacy and Safety of Insulin Degludec/Insulin Aspart and BIAsp 30 in Insulin naïve Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec/insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 89Zr-Trastuzumab PET/CT in Subjects With Previously Treated HER2-Positive Solid Tumors Scheduled to Receive Treatment With MT-5111
Status: WITHDRAWN
Conditions: HER2-positive Solid Tumor|HER-2 Positive Cancer
Interventions: DRUG: 89Zr-trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sequential Therapies Modeled on Evolutionary Dynamics for Breast Cancer
Status: RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Taxotere|DRUG: Cytoxan|DRUG: Trastuzumab deruxtecan|DRUG: Sacituzumab govitecan|DRUG: Xeloda|DRUG: Fulvestrant|DRUG: Ribociclib|DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Insulin Clamp Ancillary Study for Assessment of Insulin Resistance
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EXPAREL Administered by Infiltration Into the TAP for Prolonged Postsurgical Analgesia in Lower Abdominal Surgeries
Status: TERMINATED
Conditions: Pain
Interventions: DRUG: EXPAREL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-center Clinical Study on Neonatal Hyperbilirubinemia
Status: COMPLETED
Conditions: Quality Improvement|Hyperbilirubinemia, Neonatal
Interventions: BEHAVIORAL: Quality improvement of management of neonatal jaundice
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: OXYMIND: Oxytocin-augmented Group Psychotherapy for Patients With Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia Spectrum Disorders
Interventions: OTHER: Oxytocin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Analgesic Efficacy of a Single Dose of AZD1940
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: AZD1940|DRUG: Naproxen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The GReek Study in the Effects of Colchicine in Covid-19 cOmplications Prevention
Status: TERMINATED
Conditions: Corona Virus Disease 19 (Covid 19)
Interventions: DRUG: Colchicine|DRUG: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Apathy in Glycemic Control
Status: COMPLETED
Conditions: Apathy|Diabetes
Interventions: DRUG: methylphenidate or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the I-gel and Air-Q Supraglottic Airways as Conduits for Tracheal Intubation in Children
Status: COMPLETED
Conditions: Tracheal Intubation in Children
Interventions: DEVICE: i-gel|DEVICE: air-Q
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: