pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Neuromuscular Block in Laryngeal Mask Airway(LMA) Insertion
Status: COMPLETED
Conditions: General Anesthesia|Breast Disease
Interventions: DRUG: use of rocuronium when the LMA is inserted
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Evaluate The Role of Intravitreal Aflibercept Injection (2.0 mg) in the Management of Previously Treated Patients With Exudative AMD
Status: COMPLETED
Conditions: AMD (With Persistent or Recurrent Fluid Despite Monthly Intravitreal Anti-VEGF Therapy)
Interventions: DRUG: Alfilbercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Library-based Prevention Intervention for Adolescents Affected by Parental Drug Use
Status: COMPLETED
Conditions: Substance Use|Sexual Behavior|Adolescent Behavior
Interventions: BEHAVIORAL: Adapted FOY+ImPACT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Magnetic Occult Lesion Localization Instrument (MOLLI) Guidance System for Breast Lesion Localization
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Neoplasm
Interventions: DEVICE: MOLLI Localization
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Anti-inflammatory Analgesics on Pain Following Hallux Valgus Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: etoricoxib|DRUG: tramadol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Sorafenib in Treating Patients With Soft Tissue Sarcomas (Extremity Sarcoma Closed to Entry as of 5/30/07)
Status: COMPLETED
Conditions: Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Metastatic Osteosarcoma|Recurrent Adult Soft Tissue Sarcoma|Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Recurrent Osteosarcoma|Stage I Adult Soft Tissue Sarcoma|Stage II Adult Soft Tissue Sarcoma|Stage III Adult Soft Tissue Sarcoma|Stage IV Adult Soft Tissue Sarcoma
Interventions: DRUG: sorafenib tosylate|PROCEDURE: therapeutic conventional surgery|OTHER: laboratory biomarker analysis|OTHER: pharmacological study|PROCEDURE: computed tomography|PROCEDURE: dynamic contrast-enhanced magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Value Analysis in Patients Undergoing Self-Management Training Using a Coagulometer
Status: COMPLETED
Conditions: Post-Cardiac Surgery Patients
Interventions: OTHER: Standard of Care (SOC)|OTHER: Remote Patient Monitoring (RPM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Single-dose, Comparative Bioavailability Study of Two Formulations of Ursodiol 500mg Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ursodiol 500 MG|DRUG: Urso Forte 500Mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Skin Cleansing With Chlorhexidine to Decrease Hospital Acquired Infections
Status: COMPLETED
Conditions: Nosocomial Infection|Bacteremia|Sepsis|Pneumonia|Urinary Tract Infection|Clostridium Infection
Interventions: DRUG: 2% chlorhexidine gluconate impregnated cloth|OTHER: Daily bathing with Bar soap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Brief and Intensive Therapy for Dysphagia in Patients With Head and Neck Cancer
Status: UNKNOWN
Conditions: Deglutition Disorders|Dysphagia|Head and Neck Cancer|Radiotherapy; Complications
Interventions: OTHER: bried and intensive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Examining the Influence of Guided Meditation on Diabetes-related Distress and Glycemic Control
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: BEHAVIORAL: Guided meditation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Study to Evaluate Safety and Performance of PEEK-OPTIMA™ HA Enhanced.
Status: RECRUITING
Conditions: Degenerative Disc Disease|Spondylolisthesis|Retrolisthesis
Interventions: DEVICE: Surgery with the Keos Lumbar Interbody Fusion Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endometrial Rejuvenation Study
Status: TERMINATED
Conditions: Infertility of Uterine Origin
Interventions: DRUG: AMD3100|DRUG: Normal saline|PROCEDURE: dilation and curettage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Acute Effects of Eucaloric and Hypocaloric Carbohydrate Restriction on Liver Fat Content and Metabolism in Obese Individuals
Status: NOT_YET_RECRUITING
Conditions: NAFLD|Overweight and Obesity|Metabolic Syndrome|Diabetes
Interventions: OTHER: Dietary composition of macronutrients and calories
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Androgen Deprivation Therapy Prior to Prostatectomy for Patients With Intermediate and High Risk Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer|Prostatic Adenocarcinoma
Interventions: DRUG: degarelix injection|DRUG: degarelix injection|DRUG: androgen deprivation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two-Arm Study of a DNA Vaccine Encoding Prostatic Acid Phosphatase (PAP) in Patients With Non-Metastatic Castrate-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: pTVG-HP with rhGM-CSF|BIOLOGICAL: pTVG-HP with rhGM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Dual Checkpoint Inhibition and Cryoablation in Relapsed/Refractory Pediatric Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteosarcoma|Ewing Sarcoma|Rhabdomyosarcoma|Relapsed Pediatric Solid Tumor|Refractory Pediatric Solid Tumor|Melanoma|Hepatoblastoma|Hepatocellular Carcinoma|Neuroblastoma|Wilms Tumor
Interventions: PROCEDURE: Cryoablation Therapy|DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exoskeletal-assisted Walking to Improve Mobility, Bowel Function and Cardio-Metabolic Profiles in Persons With SCI
Status: UNKNOWN
Conditions: Spinal Cord Injury|Paraplegia|Tetraplegia
Interventions: DEVICE: Exoskeletal-assisted walking (ReWalk, Ekso)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries|Spinal Cord Injury|Spinal Cord Injury Cervical|Spinal Cord Injury Thoracic
Interventions: DEVICE: Transcutaneous spinal stimulation at 100 Hz|DEVICE: Transcutaneous spinal stimulation at 50 Hz|COMBINATION_PRODUCT: Transcutaneous spinal stimulation at 50 Hz and single dose of baclofen|COMBINATION_PRODUCT: Transcutaneous spinal stimulation at 50 Hz and single dose of tizanidine|DEVICE: Sham transcutaneous spinal stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of PGS in Infertile Female Patients With RPL
Status: COMPLETED
Conditions: Infertility, Female|Abortion, Habitual
Interventions: PROCEDURE: IVF/ICSI|GENETIC: PGS|OTHER: Without PGS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Vascular Effects of Achieving Minimal Disease Activity in Psoriatic Arthritis - a 2 Year Prospective Cohort Study
Status: COMPLETED
Conditions: Psoriatic Arthritis|Atherosclerosis|Arterial Stiffness
Interventions: OTHER: PsA MDA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effectiveness of an Eating Disorders Prevention Program for Young Women in Saudi Arabia
Status: COMPLETED
Conditions: Eating Disorder Symptom and Body Image Dissatisfaction
Interventions: OTHER: The Body Project: A Dissonance-Based Eating Disorder Prevention Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Implementing Contingency Management for Stimulant Use in Specialty Addiction Treatment Organizations
Status: NOT_YET_RECRUITING
Conditions: Stimulant Use (Diagnosis)
Interventions: BEHAVIORAL: Science to Service Laboratory
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes
Status: RECRUITING
Conditions: Knee Osteoarthritis|Knee Arthropathy|Surgery
Interventions: BEHAVIORAL: Personalized outcome prediction tool + targeted interventions|BEHAVIORAL: Standard of Care TKA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Prognostic Value of the Thickness of the Quadriceps and Abdominal Muscles Measured by Ultrasound for 28-day Mortality in Postoperative ICU Patients
Status: COMPLETED
Conditions: Sarcopenia ICU Ultrasound
Interventions: OTHER: ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigation of Endothelium in Saphenous Vein Grafts
Status: COMPLETED
Conditions: Endothelial Function of Saphenous Vein Grafts
Interventions: OTHER: Use of Maquet Vasoshield Pressure-limiting syringe on SVG|OTHER: Use of non-regulated syringe on SVG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Inhaled IAV vs Inhaled Eucalyptus for the Treatment of Nausea With Acute Migraine
Status: RECRUITING
Conditions: Migraine
Interventions: OTHER: Eucalyptus Oil Scent|OTHER: Isopropyl Alcohol Vapors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sleep Apnea Diagnosis Using a Novel Pacemaker Algorithm and Link With Aldosterone Plasma Level in Patients Presenting With Diastolic Dysfunction
Status: COMPLETED
Conditions: Sleep Apnea|Arrhythmias, Cardiac|Cardiac Diastolic Function|Hyperaldosteronism
Interventions: OTHER: pacemaker diagnostic algorithm|OTHER: Attended cardiorespiratory sleep study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Caffeine for Hypoxic-Ischemic Encephalopathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypoxic-Ischemic Encephalopathy
Interventions: DRUG: Caffeine Citrate 5 mg/kg|DRUG: Caffeine Citrate 10 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Celiac Disease in Skåne
Status: RECRUITING
Conditions: Celiac Disease in Children
Interventions: OTHER: Gluten free diet|DIETARY_SUPPLEMENT: Probiotics|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Mechanisms of Hypoglycemia Associated Autonomic Dysfunction, Q.3
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: PROCEDURE: glucose clamp|PROCEDURE: glucose clamp|PROCEDURE: glucose clamp|PROCEDURE: glucose clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Effect of Functional Training and Isometric Exercises on Pain, ROM, and Functional Status in Patients With Neck Pain
Status: COMPLETED
Conditions: Chronic Pain
Interventions: OTHER: Scapular functional training|OTHER: Cervical isometric exercises|OTHER: Moist heating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Treating Vitamin D Deficiency in Poorly Controlled Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Vitamin D|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Apimostinel + Automated Neurocognitive Training for Depression
Status: NOT_YET_RECRUITING
Conditions: Depression
Interventions: DRUG: Apimostinel Infusion, Intravenous|BEHAVIORAL: Cognitive Training|BEHAVIORAL: Sham Training|DRUG: Lactated Ringers, Intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sustaining and Improving Clinicians' Use of Evidence-Based Psychotherapy (EBP) for PTSD
Status: ACTIVE_NOT_RECRUITING
Conditions: Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: Quality Improvement Learning Community|BEHAVIORAL: Fidelity-oriented Learning Community
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Immunogenicity of an Alternative Immunization Schedule of GSK Bio's Pandemic Influenza Vaccine (GSK1119711A)
Status: COMPLETED
Conditions: Influenza|Influenza Vaccines
Interventions: BIOLOGICAL: Pandemic influenza vaccine (GSK1119711A)-formulation 1|BIOLOGICAL: Pandemic influenza vaccine (GSK1119711A)-formulation 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: EXpanded Combination of Evolocumab Plus Empagliflozin on Diabetes: EXCEED-BHS3 Trial
Status: COMPLETED
Conditions: Dyslipidemia Associated With Type II Diabetes Mellitus|Diabetes Mellitus, Type 2|Hypertension Arterial
Interventions: DRUG: Evolocumab 140 MG/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: MVA Post-Event: Administration Timing and Boost Study
Status: COMPLETED
Conditions: Smallpox
Interventions: DRUG: Placebo (subcutaneous)|DRUG: Placebo (scarification)|BIOLOGICAL: Dryvax®|BIOLOGICAL: IMVAMUNE®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Compare Pediacel® to Infanrix®-IPV+Hib When Both Are Co-Administered With Prevenar® in Infants and Toddlers
Status: COMPLETED
Conditions: Diphtheria|Tetanus|Pertussis|Poliomyelitis|Haemophilus Influenzae Type b
Interventions: BIOLOGICAL: PEDIACEL® and Prevenar®|BIOLOGICAL: Infanrix®-IPV+Hib and Prevenar®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Propranolol as Anti-Adhesive Therapy in Sickle Cell Disease (SCD)
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: Propranolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Viagra in Men With ED and LUTS Due to Benign Prostatic Hyperplasia (BPH)
Status: COMPLETED
Conditions: Impotence
Interventions: DRUG: Viagra|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Geriatric Specific Interventions for Quality of Life in Elderly Patients With Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Prostate Cancer|Lung Cancer|Lymphoma Cancer|Gynecological Cancers
Interventions: BEHAVIORAL: group intervention and questionnaires|BEHAVIORAL: individual phone intervention and questionnaires|BEHAVIORAL: expressive writing (arm will not be include in the randomization)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess Efficacy and Tolerability of Topical Skincare Products on Psoriasis Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Plaque Psoriasis|Psoriasis
Interventions: DRUG: Cetaphil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Totally Neoadjuvant FOLFOXIRI + Short-course Radiation + XELOX in Patients With Locally Advanced Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Neoplasms|Drug Therapy|Radiation
Interventions: DRUG: FOLFOXIRI|RADIATION: Short-Course Radiation Therapy(5Gy*5)|DRUG: XELOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of the Vessel Restoration System (VRS) for the Treatment of Atherosclerotic Lesions in the Superficial Femoral Artery (SFA) and/or Popliteal Artery (PA) After Sub-optimal Percutaneous Transluminal Angioplasty (PTA) or Atherectomy: REACTIVATE I
Status: ACTIVE_NOT_RECRUITING
Conditions: PAD - Peripheral Arterial Disease
Interventions: COMBINATION_PRODUCT: Vessel Restoration System (VRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metronomic Chemotherapy in Wilms Tumor (MetroWilms-1906)
Status: RECRUITING
Conditions: Wilms Tumor
Interventions: DRUG: Vincristine|DRUG: Irinotecan|DRUG: Temozolomide|DRUG: Etoposide|DRUG: Cis-Retinoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The 4-7-8 Breathing Technique on Pain and Nausea-Vomiting
Status: NOT_YET_RECRUITING
Conditions: Pain|Vomiting|Nausea|Post Operative Pain|Vomiting, Postoperative|Nausea, Postoperative
Interventions: PROCEDURE: 4-7-8 Breathing Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety of Various Mode of Delivery of Iron Supplement on Iron Toxicity Markers in Preschool Children
Status: UNKNOWN
Conditions: Iron Overload|Oxidative Stress
Interventions: DIETARY_SUPPLEMENT: Iron Supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Prehabilitation in Gastroesophageal Adenocarcinoma: Study Protocol of a Multicentric, Randomised Control Trial
Status: UNKNOWN
Conditions: Oesophageal Cancer|Gastric Cancer
Interventions: PROCEDURE: prehabilitation|OTHER: nutritional support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapy of Alzheimer's Disease With Neurofeedback
Status: COMPLETED
Conditions: Alzheimer Dementia (AD)|Elderly
Interventions: OTHER: rtfMRI neurofeedback training|DEVICE: 3T MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of SpotOn Specs™ for the Treatment of Chronic Dizziness
Status: COMPLETED
Conditions: Chronic Dizziness
Interventions: DEVICE: SpotOn's corrective elements for dizziness|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Human Plasma-Derived Alpha1-Proteinase Inhibitor in Subjects With New-Onset Type 1 Diabetes Mellitus
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus
Interventions: BIOLOGICAL: 180 mg/kg Alpha1-PI|BIOLOGICAL: 90 mg/kg Alpha1-PI|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Regional Haemodynamic Changes in Radial Artery Assessment With Continuous Pulsed-wave Doppler Ultrasound
Status: WITHDRAWN
Conditions: Lung Cancer
Interventions: DRUG: 0.5% ropivacaine paravertebral block|DRUG: 0.25% ropivacaine epidural block|DRUG: 0.5% ropivacaine local anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safty and Feasibility Study of Therapeutic Cooling in Acute Ischemic Stroke (COOLAID Øresund)
Status: COMPLETED
Conditions: Cerebral Infarction
Interventions: DEVICE: TH - Endovascular alone (Alsius®, Zoll, USA)|DEVICE: TH - Endovascular + nasopharyngeal induction (Alsius®, Zoll, USA) (Rhinochill®, Benechill, USA)|DEVICE: Intravenous cold saline and surface cooling (Arctic Sun, Medivance, USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monitoring of Anesthetic Depth and EEG Band Power Using PLE (Phase Lag Entropy) During Propofol Anesthesia
Status: UNKNOWN
Conditions: Anesthesia, General
Interventions: DEVICE: PLE (Phase Lag Entropy)|DRUG: Muscle Relaxant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison of Circumferential Pulmonary Vein Isolation Alone Versus Linear Ablation in Addition to Circumferential Pulmonary Vein Isolation for Catheter Ablation in Persistent Atrial Fibrillation: Prospective Randomized Controlled Trial
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: circumferential pulmonary vein isolation|PROCEDURE: Linear ablation in addiction to circumferential pulmonary vein isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the PD-1 Inhibitor Pembrolizumab as Maintenance Therapy After Initial Chemotherapy in Metastatic Bladder Cancer
Status: COMPLETED
Conditions: Urothelial Carcinoma|Bladder Cancer
Interventions: OTHER: Placebo|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Remote Evaluation and Monitoring of Acoustic Pathophysiological Signals With External Sensor Technology in Covid-19
Status: UNKNOWN
Conditions: Covid19
Interventions: DEVICE: Senti V1.0 Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Autologous Stem Cell Systemic Sclerosis Immune Suppression Trial
Status: TERMINATED
Conditions: Scleroderma, Systemic
Interventions: BIOLOGICAL: Peripheral Blood Stem Cells|DRUG: Cyclophosphamide|DRUG: Mesna|DRUG: rATG|DRUG: Methylprednisolone|DRUG: Filgrastim|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coronary Physiology and Its Relationship to Anatomy in Patients With Diabetes Mellitus
Status: TERMINATED
Conditions: Diabetes Mellitus|Coronary Artery Disease
Interventions: DEVICE: Pressure Wire Certus, St. Jude Medical, USA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Jet Injection for Influenza
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: AFLURIA vaccine (2012-2013 formulation)|DEVICE: Needle-Syringe|DEVICE: Stratis needle-free injection device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety Study of Soluble Ferric Pyrophosphate (SFP) in Dialysate in CKD Patients Receiving Chronic Hemodialysis
Status: COMPLETED
Conditions: End Stage Renal Disease|Chronic Kidney Disease
Interventions: DRUG: SFP|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Metabolic Flexibility on Changes in Metabolic Health
Status: ENROLLING_BY_INVITATION
Conditions: Obesity|Metabolic Syndrome
Interventions: DIAGNOSTIC_TEST: Metabolic flexibility in the fasted state|OTHER: Metabolic flexibility in euglycemic-hyperinsulinemic clamp|OTHER: Metabolic flexibility in the metabolic chamber
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pemetrexed Plus Bevacizumab in Non Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small-cell Lung Cancer
Interventions: DRUG: Pemetrexed|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Intake of Protein From Cod Fillet and Cod Residual Material on Lipid Regulation, Glucose Regulation and Inflammation in Overweight or Obese Adults.
Status: COMPLETED
Conditions: Overweight and Obesity|Healthy
Interventions: DIETARY_SUPPLEMENT: Intact cod protein from fillet|DIETARY_SUPPLEMENT: Intact cod protein from residual material|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dexmedetomidine on Postoperative Analgesia
Status: COMPLETED
Conditions: Colon Cancer, Rectal Cancer
Interventions: DRUG: Fentanyl|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of SC Injected Tc 99m Tilmanocept Localization in Active RA Subjects by SPECT and SPECT/CT Imaging
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tilmanocept
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Use of Visual Decision Aid for Shared Decision Making in Chest Pain
Status: TERMINATED
Conditions: Acute Coronary Syndrome|Chest Pain|Myocardial Infarction|Angina Pectoris
Interventions: OTHER: Chest Pain Choice visual aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of N-acetylcysteine on Oxidative Stress in COVID-19 Patients
Status: COMPLETED
Conditions: Corona Virus Disease 19 (Covid19)|Corona Virus Infection|Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV2)
Interventions: DRUG: N-acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: NAC for Attenuation of COVID-19 Symptomatology
Status: NOT_YET_RECRUITING
Conditions: Covid19|COVID-19 Pneumonia|COVID-19 Respiratory Infection|COVID-19 Lower Respiratory Infection|SARS-CoV2 Infection|SARS-CoV-2 Acute Respiratory Disease|SARS-Associated Coronavirus as Cause of Disease Classified Elsewhere|Oxidative Stress
Interventions: DRUG: N-acetylcysteine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Use of Intravenous Tranexamic Acid in Gender Affirming Mastectomy
Status: RECRUITING
Conditions: Postoperative Hematoma|Postoperative Seroma
Interventions: DRUG: Intravenous TXA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Promoting Healthy Habits With Elderlies Diabetics
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Aged|Health Behavior|Group Processes
Interventions: OTHER: Operative groups based on methodology of problematization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Effects of Intranasal Ketamine Along With rTMS for Patients With Treatment-resistant Major Depressive Disorder (TRD)
Status: UNKNOWN
Conditions: Major Depressive Disorder
Interventions: DRUG: intranasal ketamine|DEVICE: rTMS treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing Routine Versus Selective Use of Completion Angiography After Surgical Thromboembolectomy in the Treatment of Acute Lower Limb Ischemia and Their Impacts on Limb Salvage Rates
Status: COMPLETED
Conditions: Acute Limb Ischemia
Interventions: PROCEDURE: completion angiography followed by endovascular treatment of residual or underlying lesions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Molidustat for Correction of Renal Anemia in Non-dialysis Subjects
Status: COMPLETED
Conditions: Anemia|Renal Insufficiency, Chronic
Interventions: DRUG: Molidustat (BAY85-3934)|DRUG: Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allopurinol for Mania: A Randomized Trial Administering Allopurinol vs. Placebo as add-on to Mood Stabilizers and/or Antipsychotics in Patients in a Bipolar Manic Episode
Status: COMPLETED
Conditions: Mania
Interventions: DRUG: Allopurinol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of GVHD in Patients Treated With Allogeneic SCT: Possible Role of Extracorporeal Photophoresis
Status: COMPLETED
Conditions: Graft-Versus-Host Disease
Interventions: OTHER: Extracorporeal photophoresis (ECP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluate Safety and Efficacy of Innovative Medical Devices for Colostomy Patients
Status: COMPLETED
Conditions: Colostomy Stoma
Interventions: DEVICE: Hydrustoma C3|DEVICE: Coloplast Alterna
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Basket Study to Evaluate the Therapeutic Activity of Simlukafusp Alfa as a Combination Therapy in Participants With Advanced and/or Metastatic Solid Tumors
Status: TERMINATED
Conditions: Advanced/Metastatic Head and Neck, Oesophageal and Cervical Cancers
Interventions: DRUG: simlukafusp alfa|DRUG: Atezolizumab (MPDL3280A), an Engineered Anti-PD-L1 Antibody|DRUG: Gemcitabine|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Cytokine Induced Killer Cells (CIK) for Chronic Myeloid Leukemia (CML) Patients on Standard Drug Therapy
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia
Interventions: BIOLOGICAL: Autologous CIK cell infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of TENS on Pain, Complications and Comfort in Patients Who Had Prostate Biopsy With Transrectal Ultrasound
Status: COMPLETED
Conditions: Prostate Cancer XXX
Interventions: OTHER: Transcuten Electriacal Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Tailoring Post Discharge (The TPD Study)
Status: RECRUITING
Conditions: Acute Coronary Syndrome|Myocardial Infarction
Interventions: OTHER: Remote Home Monitoring (RHM)|OTHER: Rapid Response Nursing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Efficacy and Safety of Topical Administration of FMX101 in the Treatment of Moderate-to-Severe Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: FMX101|DRUG: Vehicle Foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Medications Development for Drug Abuse Disorders
Status: COMPLETED
Conditions: Opioid Related Disorders|Opioid Dependence|Opioid Addiction
Interventions: DRUG: Buprenorphine/naloxone|DRUG: Clonidine|DRUG: Tramadol ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ThuLEP vs. HoLEP vs. Monopolar Enucleation in Management of BPH
Status: COMPLETED
Conditions: Prostatic Hyperplasia, Benign|Prostate Adenoma|Lower Urinary Tract Symptoms
Interventions: PROCEDURE: Thulium-fiber laser enucleation of the prostate|PROCEDURE: Monopolar enucleation of the prostate|PROCEDURE: Ho:YAG laser enucleation of the prostate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AI-Powered ECG Detecting Culprit Vessel Blood Flow Abnormality in ACS
Status: ENROLLING_BY_INVITATION
Conditions: Acute Coronary Syndrome|STEMI|Coronary Occlusion|Coronary Syndrome|NSTEMI|NSTEMI - Non-ST Segment Elevation MI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: S9427, Suramin in Treating Patients With Stage III or Stage IV Adrenocortical Cancer Incurable by Surgery
Status: TERMINATED
Conditions: Adrenocortical Carcinoma
Interventions: DRUG: suramin|DRUG: therapeutic hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine vs Fentanyl in Controlling Labor Pain
Status: COMPLETED
Conditions: Labor Pain
Interventions: DRUG: Fentanyl|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Compex Use With Delayed Onset Muscle Soreness: A Comparison to Other Methods
Status: COMPLETED
Conditions: Focus of Study is to Determine Efficacy of Compex
Interventions: DEVICE: Compex unit's Active Recovery® program|OTHER: Ice application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chloroquine Alone or in Combination for Malaria in Children in Malawi
Status: COMPLETED
Conditions: Plasmodium Falciparum Infection
Interventions: DRUG: Atovaquone-proguanil|DRUG: Artesunate|DRUG: Azithromycin|DRUG: Chloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ustekinumab (STELARA) in Chinese Participants With Moderately to Severely Active Crohn's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn Disease
Interventions: DRUG: Ustekinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Effectiveness of Two Dosing Regimens of Fostamatinib Compared to Placebo in Patients With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate But Not Responding.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: fostamatinib|DRUG: fostamatinib|DRUG: placebo, fostamatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Thoracic Aortic Structure Assessed B PET/CT Scan and Arterial Stiffness in Elderly Patients
Status: COMPLETED
Conditions: Aging|Inflammation
Interventions: RADIATION: fludeoxyglucose(18f)|OTHER: blood sample|OTHER: cardiac and aortic magnetic resonance imaging|OTHER: carotid femoral pulse wave velocity|RADIATION: positron emission tomography|RADIATION: computed tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Strategies to Reduce Iron Deficiency
Status: COMPLETED
Conditions: Iron Deficiency
Interventions: DIETARY_SUPPLEMENT: Ferrous gluconate- 19 mg|DIETARY_SUPPLEMENT: Ferrous gluconate- 38 mg|OTHER: Letter Group- Information Provided|OTHER: Letter - No Information Provided|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CX-4945 in Viral Community Acquired Pneumonia
Status: RECRUITING
Conditions: Community-acquired Pneumonia|SARS-CoV-2 -Associated Pneumonia|Influenza With Pneumonia
Interventions: DRUG: CX-4945 (SARS-CoV-2 domain)|DRUG: Placebo (SARS-CoV-2 domain)|DRUG: CX-4945 (Influenza virus domain)|DRUG: Placebo (Influenza virus domain)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Femtosecond Small Incision Lenticular Extraction in Comparison to Femtosecond Laser Insitu Keratomileusis Regarding Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: PROCEDURE: FS-SMILE|PROCEDURE: S-LASIK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Mobile Application in the Smoking Cessation Among Young People
Status: UNKNOWN
Conditions: Smoking Cessation
Interventions: OTHER: Control group|DEVICE: Cell phone Aplication for Smarth Phone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IDH1 Inhibition Using Ivosidenib as Maintenance Therapy for IDH1-mutant Myeloid Neoplasms Following Allogeneic Stem Cell Transplantation
Status: COMPLETED
Conditions: IDH1 Mutation Myeloid Neoplasms
Interventions: DRUG: Ivosidenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Method of Early Diagnosis of Laryngopharyngeal Reflux
Status: COMPLETED
Conditions: Laryngopharyngeal Reflux|Laryngopharyngitis Chronic|Gastro Esophageal Reflux|Laryngitis
Interventions: DIAGNOSTIC_TEST: pH metry|DIAGNOSTIC_TEST: Filling out the questionnaire|DEVICE: Endoscopic laryngoscopy|DEVICE: Acoustic voice analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Computer Guided for Mandibular Distraction Osteogenesis
Status: COMPLETED
Conditions: Hemifacial Microsomia
Interventions: OTHER: 3D printed surgical guide constructed|OTHER: free hand surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Crossover Blinded Trial of Cell Therapy Versus Placebo in COPD
Status: WITHDRAWN
Conditions: COPD|Emphysema or COPD|Chronic Bronchitis
Interventions: PROCEDURE: Treatment Then Placebo|PROCEDURE: Placebo Then Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I, Double Blind, Placebo Controlled, First in Human, Single and Multiple Ascending Oral Dose, Safety, Tolerability and Pharmacokinetic Study in Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: PXT002331
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Combining Myocardial Strain and Cardiac CT to Optimize Left Ventricular Lead Placement in CRT Treatment
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: Imaging guided LV lead positioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reactogenicity, Safety and Immunogenicity of a TB/FLU-04L Tuberculosis Vaccine
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: tuberculosis vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Deferasirox on Response Rate of Acute Leukemia Patients Not Treated by Standard Chemotherapy Regimens
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia|Acute Lymphoid Leukemia
Interventions: DRUG: Cytarabine|DRUG: Deferasirox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GLP-1 and Microvascular Function in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Liraglutide|OTHER: diet|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Androgen Deprivation Therapy on Bone Mineral Density Change in Prostate Cancer Patients
Status: UNKNOWN
Conditions: Prostatic Neoplasms
Interventions: DRUG: Leuprorelin|DRUG: Goserelin|DRUG: Triptorelin|DRUG: Degarelix|DRUG: Bicalutamide|DRUG: Flutamide|DRUG: Maximum androgen blockade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preemptive Lung Impedance-Guided Therapy in Evolving Acute Heart Failure in Acute Myocardial Infarction Patients
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: Usual treatment of patients with developing acute heart failure|DEVICE: Lung Impedance-Guided Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Evaluation of a Mask Seal/Mask for the Treatment of Obstructive Sleep Apnea (OSA)
Status: COMPLETED
Conditions: Sleep Disordered Breathing|Obstructive Sleep Apnea
Interventions: DEVICE: F&P Mask Seal|DEVICE: F&P Mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Ship - Shaped Adhesive Tape Fixing in Patients Undergoing Tracheal Intubation
Status: COMPLETED
Conditions: The Fixation Mainly Plays a Firm Role in the Tracheal Intubation and Reduces the Occurrence of Complications
Interventions: BEHAVIORAL: 3M tape ship-shaped combined with strap fixing method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of Tiotropium in Patients of African Descent With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium Bromide Inhalation Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparing Ciprofol and Propofol for Sedation in Hypotensive ICU Patients: a Single Center Prospective Cohort Study
Status: RECRUITING
Conditions: Ciprofol|Propofol|Sedation|Low Blood Pressure|Norepinephrine
Interventions: DRUG: ciprofol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Doxycycline Treatment to Prevent Progressive Coronary Artery Dilation in Children With Kawasaki Disease
Status: UNKNOWN
Conditions: Kawasaki Disease|Coronary Aneurysm
Interventions: DRUG: Doxycycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Molecular Basis of Langerhans and Non-Langerhans Cell Histiocytic Neoplasms and Castleman Disease
Status: SUSPENDED
Conditions: Castleman's Disease (CD)|Langerhans Cell Histiocytosis (LCH)|Non-Langerhans-Cell Histiocytosis
Interventions: DIAGNOSTIC_TEST: Genetic testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Comparative Bioavailability and Local Tolerability of Two Topical Diclofenac Plasters Applied Once and Twice a Day
Status: COMPLETED
Conditions: Bioequivalence Study
Interventions: DRUG: Diclofenac Sodium 140mg Medicated Plaster|DRUG: Flector® topical plaster containing 180 mg of diclofenac hydroxyethylpyrrolidine equivalent to 140 mg of sodium diclofenac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER