pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Confirm the Efficacy and Safety of Fludarabine Phosphate Administered in Untreated Chronic Lymphocytic Leukemia Patients With Anemia and/or Thrombocytopenia
Status: COMPLETED
Conditions: Leukemia, Lymphocytic, Chronic, B-Cell
Interventions: DRUG: Fludarabine Phosphate (Fludara)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Chemotherapy After Preoperative Chemoradiotherapy to Treat Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: DRUG: Adjuvant FL|DRUG: Adjuvant FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of the Updated Version of the School-based Program Diario Della Salute (DDS-2)
Status: COMPLETED
Conditions: Adolescent Behavior|Health Behavior|Mental Health Wellness 1
Interventions: BEHAVIORAL: Diario della Salute (DDS-2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Varlilumab (Anti-CD27) and Sunitinib in Patients With Metastatic Clear Cell Renal Cell Carcinoma
Status: TERMINATED
Conditions: Carcinoma, Renal Cell|Kidney Diseases|Kidney Neoplasms|Urogenital Neoplasms|Urologic Diseases|Urologic Neoplasms|Neoplasms|Neoplasms by Histologic Type|Clear-cell Metastatic Renal Cell Carcinoma
Interventions: DRUG: Combination of varlilumab and sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assess the Clinical Effectiveness in AI Prioritising CT Heads
Status: RECRUITING
Conditions: Trauma, Brain|Mass Lesion|Skull Fractures|Hemorrhage, Intracranial|Midline Deviation|Stroke, Ischemic|Encephalomalacia
Interventions: DEVICE: qER (qER EU 2.0)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Association Between Circulating Immune Cells and the Tumor Immune Contexture in Resectable Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Resectable Non-small Lung Cancer
Interventions: PROCEDURE: blood drawn|PROCEDURE: surgical resection of cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Flossing Band Integration in Conventional Physiotherapy for Patellofemoral Pain Syndrome
Status: COMPLETED
Conditions: Anterior Knee Pain Syndrome|Patellofemoral Pain Syndrome
Interventions: PROCEDURE: Flossing band|OTHER: Conventional physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Focal Segmental Glomerulosclerosis Clinical Trial (FSGS-CT)
Status: COMPLETED
Conditions: Glomerulosclerosis, Focal
Interventions: DRUG: Cyclosporin|DRUG: MMF and Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modified Double Wire Technique to Facilitate the Successful Cannulation
Status: UNKNOWN
Conditions: Biliary Cannulation|Endoscopic Retrograde Cholangiopancreatography
Interventions: PROCEDURE: Modified double wire technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hypocaloric Enteral Nutrition in the Critically Ill Patient
Status: COMPLETED
Conditions: Critically Ill
Interventions: DIETARY_SUPPLEMENT: Hipocaloric enteral nutrition|DIETARY_SUPPLEMENT: Normocaloric enteral nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reward Emotion Learning and Ketamine Study
Status: RECRUITING
Conditions: Depression|Major Depressive Disorder|Treatment Resistant Depression
Interventions: DRUG: Ketamine Hydrochloride|OTHER: No intervention (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Clinical Research Study For The Suppression And Treatment Of Genital Herpes Infection In HIV-Infected Persons
Status: TERMINATED
Conditions: Herpes Genitalis
Interventions: DRUG: valacyclovir hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Regorafenib Plus Raltitrexed as Third-line Treatment in Advanced Colorectal Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: Regorafenib|Raltitrexed|Colorectal Neoplasms|Third-line Treatment
Interventions: DRUG: Regorafenib|DRUG: Raltitrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Rimegepant and Placebo for Pain in IBS
Status: RECRUITING
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Rimegepant 75 MG [Nurtec]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability, and Efficacy Study of VC-02™ Combination Product in Subjects With Type 1 Diabetes Mellitus and Hypoglycemia Unawareness
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus With Hypoglycemia
Interventions: COMBINATION_PRODUCT: VC-02 Combination Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Online Validation of Dietary Intake Food Frequency Questionnaire Over Four Weeks, and Electronic Device Use Questionnaire Over Eight Weeks.
Status: COMPLETED
Conditions: Lutein and Zeaxanthin Dietary Intake|Age Related Macular Degeneration|Blue Light Exposure|Electronic Device Use
Interventions: OTHER: Weekly Food Frequency Questionnaire|OTHER: Monthly Food Frequency Questionnaire|OTHER: 24-Hour Diet Recall|OTHER: Electronic Device Use Questionnaire|OTHER: 24-Hour Electronic Device Use Diary
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: AMG0103 in Subjects With Chronic Discogenic Lumbar Back Pain
Status: COMPLETED
Conditions: Degenerative Disc Disease
Interventions: DRUG: Placebo|DRUG: AMG0103
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 68-Ga-RM2 PET/MRI in Imaging Patients With Estrogen Receptor-Positive Breast Cancer
Status: COMPLETED
Conditions: Breast Carcinoma|Estrogen Receptor Positive
Interventions: DRUG: Gallium Ga 68-labeled GRPR Antagonist BAY86-7548|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|DEVICE: Investigational software and coils in PET/MR scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase 1b Lymphoma Study of AMG 655 in Combination With Bortezomib or Vorinostat
Status: COMPLETED
Conditions: Hodgkin's Lymphoma|Low Grade Lymphoma|Lymphoma|Mantle Cell Lymphoma|Non-Hodgkin's Lymphoma|Diffuse Large Cell Lymphoma
Interventions: DRUG: AMG 655|OTHER: Vorinostat|OTHER: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Intranasal Glucagon in Children and Adolescents With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Nasal Glucagon|DRUG: Intramuscular Glucagon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeted Radiotherapy in HSCT for Poor Risk Haematological Malignancy
Status: COMPLETED
Conditions: Acute Leukaemia|Chronic Leukaemia|Myeloma|Lymphoma
Interventions: RADIATION: Targeted radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Anlotinib in Combination With Irinotecan in Patients With Pretreated Advanced Colorectal Cancer
Status: UNKNOWN
Conditions: Colo-rectal Cancer
Interventions: DRUG: Anlotinib Hydrochloride with Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vital USA SpO2 Accuracy Comparison to Arterial Blood CO-Oximetry
Status: COMPLETED
Conditions: Arterial Disease
Interventions: DEVICE: Accuracy of the VitalDetect™ pulse oximetry system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study Comparing The Efficacy And Safety Of Lidocaine 5% Patch With Placebo In Patients With Chronic Axial Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: DRUG: Lidoderm®|DRUG: Placebo Topical Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Inhaled Long-acting Bronchodilators With or Without Inhaled Glucocorticosteroids for Preventing Hospitalizations and Death in Elderly Patients With Chronic Obstructive Pulmonary Disease
Status: TERMINATED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Bronchodilator Agents|DRUG: Bronchodilator Agents|DRUG: Bronchodilator Agents|DRUG: Bronchodilator Agents|DRUG: Bronchodilator Agents|DRUG: Bronchodilator Agents|DRUG: Bronchodilator Agents|DRUG: Bronchodilator Agents|DRUG: Bronchodilator Agents|DRUG: Bronchodilator Agents|DRUG: Bronchodilator Agents|DRUG: Bronchodilator Agents|DRUG: Bronchodilator Agents|DRUG: Bronchodilator Agents|DRUG: Bronchodilator Agents|DRUG: Bronchodilator Agents|DRUG: Bronchodilator Agents|DRUG: Bronchodilator Agents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: REPAIR - transcatheteR rEPair of mitrAl Insufficiency With caRdioband System
Status: TERMINATED
Conditions: Mitral Valve Insufficiency|Cardiac Valve Annuloplasty|Mitral Valve Annuloplasty|Cardiovascular Diseases|Heart Diseases|Heart Valve Diseases|Mitral Regurgitation
Interventions: DEVICE: Cardioband
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Social Cognition and Personality Changes in Alzheimer's & Parkinson's Disease & Frontotemporal Lobar Degeneration
Status: UNKNOWN
Conditions: Alzheimer's Disease|Parkinson's Disease|Frontotemporal Lobar Degeneration
Interventions: BEHAVIORAL: Observational Study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: GW572016 In Patients With ErbB2 Over - Expressing Advanced Or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Neoplasms, Breast
Interventions: DRUG: lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monoclonal Antibody for Treatment of Inhalation Anthrax
Status: COMPLETED
Conditions: Bacillus Anthracis (Anthrax)
Interventions: DRUG: Ciprofloxacin 500 mg|DRUG: ETI-204 (Anthim)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: T4N5 Liposome Lotion Compared With Placebo Lotion for Preventing Actinic Keratoses in Patients With Xeroderma Pigmentosum
Status: UNKNOWN
Conditions: Precancerous Condition
Interventions: DRUG: liposomal T4N5 lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Dabigatran Versus Warfarin With NVAF Who Undergo PCI
Status: UNKNOWN
Conditions: Atrial Fibrillation|Coronary Artery Disease
Interventions: DRUG: dabigatran|DRUG: warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Perineal Massage (PERMAS)
Status: COMPLETED
Conditions: Musculoskeletal Manipulations|Primary Prevention|Obstetric Labor Complications|Physical Therapy Modalities
Interventions: PROCEDURE: Self-provided perineal massage|PROCEDURE: Physiotherapist perineal massage: manual and instrumental (with EPI-NO)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study of Albumin-bound Paclitaxel Plus Nedaplatin in Cervical Cancer
Status: UNKNOWN
Conditions: Uterine Cervical Cancer
Interventions: DRUG: albumin-bound paclitaxel plus nedaplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir With and Without Ribavirin in Protease-Inhibitors ("PI") Failures
Status: UNKNOWN
Conditions: Hepatitis C
Interventions: DRUG: 12 weeks without Ribavirin|DRUG: 12 weeks with Ribavirin|DRUG: 24 weeks with Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Controlled Study to Evaluate the Sensitizing Potential of FMX-101 in Healthy Volunteers Using a Repeat Insult Patch Test Design
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: FMX-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of N-Acetylcysteine (NAC) and Continuous Renal Replacement Therapy (CRRT) for the Treatment of Rhabdomyolysis
Status: COMPLETED
Conditions: Rhabdomyolysis
Interventions: DRUG: N-Acetylcysteine|OTHER: N-Acetylcystine and Non CRRT|OTHER: Placebo and CRRT|OTHER: Placebo and Non CRRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of MK0524A on Flushing Caused by Niacin (0524A-056)
Status: COMPLETED
Conditions: Flushing
Interventions: DRUG: MK0524A, /Duration of Treatment : 4 Weeks|DRUG: Comparator : niacin /Duration of Treatment : 1 Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Data on the Impact of Different Treatment on the Quality of Life of Patients With Acute and Chronic Hemorrhoid Disease
Status: COMPLETED
Conditions: Hemorrhoids
Interventions: PROCEDURE: Hemorrhoidectomy, Thrombectomy , Operation on Longo method|DRUG: Detralex|OTHER: Combined therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Topiramate: Long-Term Maintenance of Weight Loss Induced by Low-Calorie Diet in Obese Subjects
Status: TERMINATED
Conditions: Obesity
Interventions: DRUG: Topiramate 96 mg daily|DRUG: Topiramate 192 mg daily|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of The Vaginal Renewal™ Program in Gynecologic Cancer Patients Experiencing Sexual Dysfunction
Status: TERMINATED
Conditions: Sexual Dysfunction, Physiological
Interventions: DEVICE: Vaginal Renewal Program|DEVICE: Vaginal Dilator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Impact of the Biopsy of 1-2 Cells in a PGD Program for Anueploidy Screening
Status: COMPLETED
Conditions: Healthy
Interventions: PROCEDURE: Biopsy of Day 3 Embryo|PROCEDURE: · day embryo biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Music-with-movement Exercise Program for Community-dwelling Older Adults Suffering From Chronic Pain: a Pilot Randomized Controlled Trial
Status: UNKNOWN
Conditions: Chronic Pain|Elderly|Music-with-movement Exercise|Pain Management
Interventions: OTHER: Music-with-movement exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Interpretation of Health News Items Reporting Results of Randomized Controlled Trials With or Without Spin by English-speaking Population
Status: WITHDRAWN
Conditions: The Study Focus on no Specific Condition
Interventions: OTHER: News items with spin|OTHER: News items without spin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: 3D Time-of-Flight Magnetic Resonance Angiography in Hemodialysis Patients With Arteriovenous Fistula
Status: COMPLETED
Conditions: Magnetic Resonance Angiography|Hemodialysis|Arteriovenous Fistula Stenosis
Interventions: DIAGNOSTIC_TEST: 3D-TOF-MRA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of FT-2102 in Patients With Advanced Solid Tumors and Gliomas With an IDH1 Mutation
Status: COMPLETED
Conditions: Cohort 1a and 1b: Glioma (Advanced Gliomas and Glioblastoma Multiforme)|Cohort 2a and 2b: Hepatobiliary Tumors (Hepatocellular Carcinoma, Bile Duct Carcinoma, Intrahepatic Cholangiocarcinoma, Other Hepatobiliary Carcinomas)|Cohort 3a and 3b: Chondrosarcoma|Cohort 4a and 4b: Intrahepatic Cholangiocarcinoma|Cohort 5a: Other Non-Central Nervous System Solid Tumors With IDH1 Mutations
Interventions: DRUG: FT-2102|DRUG: Azacitidine|BIOLOGICAL: Nivolumab|DRUG: Gemcitabine and Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Donanemab (LY3002813) in Healthy Chinese Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Donanemab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PS-341 in Treating Patients With Metastatic Malignant Melanoma
Status: COMPLETED
Conditions: Recurrent Melanoma|Stage IV Melanoma
Interventions: DRUG: bortezomib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib, Tislelizumab Combined With Gemcitabine and Cisplatin (GPLET) in the Treatment of Advanced Cholangiocarcinoma
Status: RECRUITING
Conditions: Advanced Cholangiocarcinoma
Interventions: DRUG: Lenvatinib, tislelizumab, gemcitabine and cisplatin|DRUG: Gemcitabine and cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Moxifloxacin i.v. in the Treatment of Complicated Intra-Abdominal Infection (cIAI)
Status: COMPLETED
Conditions: Secondary Peritonitis|Abscess, Intra-Abdominal
Interventions: DRUG: Moxifloxacin (Avelox, BAY12-8039)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Camrelizumab in Combination With Neoadjuvant Chemotherapy in the Treatment of Osteosarcoma
Status: UNKNOWN
Conditions: Osteosarcoma
Interventions: DRUG: Camrelizumab in Combination With Neoadjuvant Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Effect of Rifampin and Itraconazole on the Action of Pamiparib in Participants With Cancer
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: pamiparib 60 mg|DRUG: pamiparib 20 mg|DRUG: itraconazole|DRUG: rifampin|DRUG: pamiparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: EYEFILL® C. -US Viscoelastic Clinical Investigation
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: EYEFILL® C.-US Viscoelastic|DEVICE: Healon® Viscoelastic (CONTROL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Palonosetron and Blood Coagulation
Status: RECRUITING
Conditions: Blood Coagulation Disorder
Interventions: DRUG: 0 ul of palonosetron|DRUG: 1 ul of palonosetron|DRUG: 10 ul of palonosetron|DRUG: 100 ul of palonosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cardio and Renovascular Effects of Isometric Exercise in the Healthy Human Measured by PET/CT and MRI
Status: RECRUITING
Conditions: Kidneys
Interventions: PROCEDURE: MRI|PROCEDURE: PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Direct Access Physiotherapy in the Pediatric Emergency Department
Status: COMPLETED
Conditions: Musculoskeletal Pain|Musculoskeletal Diseases or Conditions
Interventions: OTHER: Interdisciplinary management|OTHER: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Smoking Cessation Intervention
Status: TERMINATED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Spotlight on Smoke-Free Living: Mindsets and Decisions|DRUG: Transdermal Nicotine Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Busulfan and Cyclophosphamide Followed By ALLO BMT
Status: TERMINATED
Conditions: Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: Allopurinol|DRUG: Keppra|DRUG: Busulfan|DRUG: Cyclophosphamide|DRUG: Tacrolimus|DRUG: Mycophenolate mofetil|BIOLOGICAL: Allogeneic hematopoietic stem cell transplant|BIOLOGICAL: Filgrastim|BIOLOGICAL: antithymocyte globulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-agent Capecitabine as Adjuvant Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Obstructive Sleep Apnea Treatment by Fixed CPAP and by Auto-CPAP (Somnosmart2)
Status: COMPLETED
Conditions: Obstructive Sleep Apnea Syndrome
Interventions: DEVICE: Automatic (variable, automatically controlled) pressure CPAP|DEVICE: fixed continuous positive airway pressure (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Post-operative Epidural Analgesia After Minimally Invasive Lumbar Decompression and Fusion
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: Bupivicaine, Hydromorphone|DRUG: Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Safety and Immunogenicity Study of VAX102 [Flagellin.HuM2e] Influenza Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Influenza Infection
Interventions: BIOLOGICAL: VAX102 [Flagellin.HuM2e]|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Renal Angiomyolipomas in Tuberous Sclerosis by Beta-blockers
Status: COMPLETED
Conditions: Renal Angiomyolipomas|Tuberous Sclerosis
Interventions: DRUG: Propranolol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prolonged Prone Positioning for COVID-19-induced Acute Respiratory Distress Syndrome (ARDS)
Status: COMPLETED
Conditions: ARDS|Covid19|Acute Hypoxemic Respiratory Failure
Interventions: OTHER: Prolonged Proned Positioning|OTHER: Traditional Proning Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine (ALVAC-HIV vCP1452) Use and Intermittent Withdrawal of Anti-HIV Drugs in Patients With HIV
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: ALVAC(2)120(B,MN)GNP (vCP1452)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Antihypertensive Effect of Fermented Milk With Lactococcus Lactis on Prehypertensive Subjects
Status: COMPLETED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: Fermented milk|DIETARY_SUPPLEMENT: Acidified milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prognostic Predictors of Response to Hypoglycemic Therapy
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Automatic system guided treatment|DRUG: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Significance of Antibodies to Heparin/Platelet Factor 4 Complex in Vein Graft Patency and Potential Role of Argatroban for Prevention of Vein Graft Occlusion
Status: TERMINATED
Conditions: Coronary Artery Bypass Graft Surgery|Presence of Heparin/Platelet Factor 4 Antibody
Interventions: DRUG: Argatroban and warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Molecular Hydrogen Administration on Performance and Body Response on Exercise in National-level Fin-swimmers
Status: COMPLETED
Conditions: Athletic Performance|Muscle Fatigue|Oxidative Stress
Interventions: DIETARY_SUPPLEMENT: Hydrogen rich water|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Trial Evaluating MGTA-456 in Patients With High-Risk Malignancy
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Acute Lymphocytic Leukemia|Biphenotypic/Undifferentiated Leukemia|Chronic Myelogenous Leukemia|Myelodysplasia|Relapsed Large Cell Lymphoma|Mantle Cell Lymphoma|Hodgkin Lymphoma|Burkitt Lymphoma|Relapsed T-Cell Lymphoma|Lymphoplasmacytic Lymphoma
Interventions: DRUG: Fludarabine (FLU)|DRUG: Cyclophosphamide (CY)|DRUG: Total Body Irradiation (TBI)|DRUG: Tacrolimus (Tac)|DRUG: Mycophenolate Mofetil (MMF)|DRUG: Granulocyte Colony-Stimulating Factor (G-CSF)|DRUG: Busulfan (BU)|DRUG: Melphalan|DRUG: MGTA 456 Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The RAPID - PE Study: RESCUE Advanced Protocol for the Treatment of Pulmonary Embolism
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Embolism
Interventions: DEVICE: The Bashir™ Endovascular Catheter|DRUG: r-tPA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Rayaldee for Treating Mild to Moderate COVID-19
Status: COMPLETED
Conditions: COVID-19|Coronavirus|SARS-CoV2 Infection
Interventions: DRUG: Rayaldee|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Metastatic Breast Cancer Who Have Received Endocrine Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced or Unresectable Metastatic Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: Sacituzumab Govitecan-hziy|DRUG: Paclitaxel|DRUG: Nab-paclitaxel|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minocycline's Effects on Alcohol Responses in Humans
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: Minocycline|DRUG: Placebo (for Minocycline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone and Post-tonsillectomy Pain in Children
Status: COMPLETED
Conditions: Pediatric Post-tonsillectomy Pain
Interventions: DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY2495655 in Older Participants Undergoing Elective Total Hip Replacement
Status: COMPLETED
Conditions: Muscular Atrophy
Interventions: DRUG: LY2495655|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MR-Only Based Adaptive External Beam Radiation Therapy of Cervical Cancer on Ethos Therapy: Feasibility Study
Status: RECRUITING
Conditions: Cervical Cancer|Online Adaptative Radiation Therapy|MRI
Interventions: DIAGNOSTIC_TEST: Magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studying Genes Using Cord Blood and Placenta Samples From Relatively Healthy Newborns and Samples From Younger Patients With Wilms Tumor
Status: COMPLETED
Conditions: Kidney Cancer
Interventions: GENETIC: DNA methylation analysis|GENETIC: RNA analysis|GENETIC: allele-specific oligonucleotide real-time quantitative polymerase chain reaction|GENETIC: gene expression analysis|GENETIC: nucleic acid sequencing|GENETIC: polymorphism analysis|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Physical Activity and Various Aspects of Quality of Life in Patients With Pulmonary Arterial Hypertension (Ph-PAH)
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension|Physical Inactivity
Interventions: BEHAVIORAL: recommendation to increase physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: METhotrexate Therapy Effects in the Physical Capacity of Patients With ISchemic Heart Failure (METIS Trial)
Status: COMPLETED
Conditions: Heart Failure|Myocardial Ischemia
Interventions: DRUG: Methotrexate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploring Cerebrolysin in Late Thrombectomy for Stroke: Blood-brain Barrier Biomarkers and Imaging Insights
Status: NOT_YET_RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Cerebrolysin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of Magne-B6 New Formulation
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: MAGNE-B6 Oral Solution|DRUG: MAGNE-B6 New Formulation Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Guided Self-determination Intervention Versus Attention Control for People With Type 2 Diabetes in Outpatient Clinics
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Guided self-determination|BEHAVIORAL: Personal support in goal-pursuing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Probiotic-Muscle Study
Status: COMPLETED
Conditions: Old Age; Debility|Muscle Weakness|Protein Deregulation|Protein Deposition
Interventions: DIETARY_SUPPLEMENT: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Therapeutic Use of Convalescent Plasma in the Treatment of Patients With Moderate to Severe COVID-19
Status: UNKNOWN
Conditions: COVID-19|SARS-CoV-2 Infection|Severe Acute Respiratory Syndrome Coronavirus 2
Interventions: BIOLOGICAL: COVID-19 convalescent plasma (CCP) plus standard of care (SOC)|BIOLOGICAL: Standard of care (SOC) plus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Study of Cognitive Behavioral Therapy for Adults With Attention Deficit Disorder
Status: COMPLETED
Conditions: Attention Deficit Disorder
Interventions: BEHAVIORAL: CBT only|BEHAVIORAL: CBT with booster sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glutamatergic Modulation of Disordered Alcohol Use
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: CI-581a|DRUG: CI-581b|BEHAVIORAL: Motivational Enhancement Therapy (MET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Community Pharmacy-Based Prescription Drug Monitoring Program Opioid Risk Assessment Tool
Status: NOT_YET_RECRUITING
Conditions: Opioid Abuse|Prescription Opioid Abuse
Interventions: BEHAVIORAL: Clinical Decision Support Tool (Moderate Risk)|BEHAVIORAL: Clinical Decision Support Tool (High Risk)|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of NMES on Muscle Function of Patients With FSHD: a Double-blind Randomized Controled Clinical Trial
Status: TERMINATED
Conditions: Primary Disease Facioscapulohumeral Dystrophy (FSHD)
Interventions: OTHER: Current flow between sensory and motor threshold|DEVICE: Current intensity upper of motor threshold by Kneehab XP technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluating the Haemostatic Effect of NNC 0129-0000-1003 During Surgical Procedures in Subjects With Haemophilia A.
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A
Interventions: DRUG: turoctocog alfa pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Sintilimab Compared With Docetaxel or Pemetrexed as Second-line Treatment for Patients With Stage IV Nonsquamous Non-small Cell Lung Cancer After Failure With Platinum-Containing Chemotherapy
Status: UNKNOWN
Conditions: Nonsquamous Non-Small Cell Lung Cancer
Interventions: DRUG: Sintilimab|DRUG: Docetaxel|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter, Randomized, Controlled and Double-blind Study of Efficacy and Safety of Endoscopic Gastric Tubulization in Patients With Non-alcoholic Steatohepatitis (NASH-APOLLO).
Status: UNKNOWN
Conditions: Non-Alcoholic Fatty Liver Disease|Obesity
Interventions: DEVICE: Endoscopic Gastric Tubulization with OverStitch® system (Apollo Endosurgery, Austin, TX, USA)|BEHAVIORAL: Lifestyle modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of the Modified Atkins Diet in Infantile Spasms
Status: COMPLETED
Conditions: Infantile Spasms
Interventions: DIETARY_SUPPLEMENT: modified Atkins diet|OTHER: modified Atkins diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Refeeding IntOlerance After Nasogastric Tube Feeding (ORION)
Status: WITHDRAWN
Conditions: Acute Pancreatitis
Interventions: PROCEDURE: Nasogastric Tube Feeding|OTHER: Conventional Nutritonal Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Transplanting Bone Marrow Cells Into Salivary Glands to Treat Dry Mouth Caused by Radiation Therapy
Status: RECRUITING
Conditions: Head and Neck Cancer|Xerostomia
Interventions: DRUG: MSC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Metformin vs Oral Contraceptives on CV Risk Markers in PCOS
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Metformin|DRUG: Ethynyl-estradiol plus cyproterone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Macitentan to Prevent PRVO
Status: WITHDRAWN
Conditions: Pulmonary Embolism
Interventions: DRUG: Macitentan 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Anetumab Ravtansine or Paclitaxel in Treating Patients With Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Fallopian Tube Endometrioid Adenocarcinoma|Fallopian Tube High Grade Serous Adenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian High Grade Serous Adenocarcinoma|Platinum-Resistant Fallopian Tube Carcinoma|Platinum-Resistant Ovarian Carcinoma|Platinum-Resistant Primary Peritoneal Carcinoma|Primary Peritoneal High Grade Serous Adenocarcinoma
Interventions: BIOLOGICAL: Anetumab Ravtansine|BIOLOGICAL: Bevacizumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes of Disposable Distal Attachment Device (Endocuff and Transparent Plastic Cap) Assisted Colonoscopy
Status: WITHDRAWN
Conditions: Colorectal Neoplasms
Interventions: DEVICE: Device Assisted Colonoscopy|DEVICE: Standard Colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Metformin and Dietary Restriction to Prevent Age-related Morbid Events in People With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DRUG: Metformin Hydrochloride 850 MG Oral Tablet [Glucophage]|DRUG: Ludipress, mg stereate, micronized hydrated silica, talcum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study Of Effects Of Oral CREON Capsules In Adult Participants With Exocrine Pancreatic Insufficiency Not Due To Cystic Fibrosis, Chronic Pancreatitis, Pancreatectomy, Or Pancreatic Cancer
Status: WITHDRAWN
Conditions: Exocrine Pancreatic Insufficiency (EPI)
Interventions: DRUG: CREON
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Blood Levels of PF-03654746 in Subjects With Mild to Moderate Alzheimer's Disease
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: PF-03654746|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Allogeneic Human Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) to Treat Perianal Fistulas Patients With Crohn's Disease
Status: RECRUITING
Conditions: Perianal Fistula Due to Crohn's Disease|Fistula in Ano
Interventions: BIOLOGICAL: PF2020-CELL (UC-MSCs) - Allogeneic Human Umbilical Cord Mesenchymal Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pelvic Floor Magnetic Stimulation in Women With Idiopathic Overactive Bladder
Status: COMPLETED
Conditions: Urge Incontinence Episodes After the Magnetic Stimulation Added to Bladder Training in Women With Idiopathic Overactive Bladder
Interventions: DEVICE: Magnetic stimulation -Armchair type (MS)|OTHER: Bladder Training (BT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of a New "Boosting" Strategy for HIV Pre-exposure Prophylaxis in Healthy Volunteers
Status: COMPLETED
Conditions: Pre-Exposure Prophylaxis
Interventions: DRUG: Probenecid Oral Tablet|DRUG: Tenofovir disoproxil fumarate/Emtricitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacogenetics of Warfarin Induction and Inhibition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Control - Warfarin only|DRUG: Fluconazole - Warfarin|DRUG: Rifampin - Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Rizatriptan in Acute Treatment of Migraine in Patients With Unilateral Trigeminal-autonomic Symptoms.
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: rizatriptan or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Healthy Adult Male Facial Skin Surface Lipid Pheromone p.o. to Treat Opioid Addiction
Status: UNKNOWN
Conditions: Opioid Addiction|Opioid Abuse, Continuous Use|Opioid Use|Opioid-Related Disorders|Paternal Pheromone Deficiency|Opioid Dependence|Opioid Abuse|Opioid-use Disorder|Opioid Intoxication|Opioid Abuse, Episodic
Interventions: BIOLOGICAL: 250mg healthy adult male facial skin surface lipid liquid pheromone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lymphedema Screening
Status: UNKNOWN
Conditions: Lymphedema
Interventions: DIAGNOSTIC_TEST: Circumference tape measurements|DIAGNOSTIC_TEST: Indocyanine green lymphangiography|DIAGNOSTIC_TEST: bioimpedance spectroscopy|DIAGNOSTIC_TEST: Symptom score
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Minimal Invasive Breast Cancer Excision Using the Breast Lesion Excision System Under Ultrasound Guidance
Status: TERMINATED
Conditions: Breastcancer
Interventions: DEVICE: BLES system and conventional lumpectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Cohort Follow-up of French Patients With Profound and Multiple Disabilities: Healthcare Pathways and Quality of Life Among Patients and Their Families
Status: UNKNOWN
Conditions: Paraparesis|Tetraparesis|Hemiparesis|Ataxia|Neuromuscular Disorders|Extrapyramidal Motor Disorders
Interventions: BEHAVIORAL: quality of life questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: European FIH Study - NeoChord Transcatheter Mitral Repair System for Symptomatic Mitral Regurgitation
Status: UNKNOWN
Conditions: Mitral Valve Insufficiency|Mitral Valve Prolapse|Degenerative|Mitral Regurgitation|Heart Valve Diseases|Heart Diseases|Cardiovascular Diseases
Interventions: DEVICE: NeoChord Transcatheter Mitral Repair System (or "NeoChord System")
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of Angeliq in Thai Women
Status: COMPLETED
Conditions: Postmenopause
Interventions: DRUG: Estradiol/DRSP (Angeliq, BAY86-4891)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of a Blended Intervention Targeting Emotion Dysregulation in Adults With ADHD
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: Emotion Regulation Intervention for ADHD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intra-lesional Injections of Glucantime Once a Week or Twice a Week in the Treatment of Anthroponotic Cutaneous Leishmaniasis (ACL)
Status: COMPLETED
Conditions: Cutaneous Leishmaniasis
Interventions: DRUG: Meglumine antimoniate|DRUG: Meglumine antimoniate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT