pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Determinants of Resistance to Endocrine Therapy and a Cyclin-dependent Kinases 4 and 6 (CDK4/6) Inhibitor for HR+ MBC
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Endocrine Therapy and a CDK 4/6 inhibitor|DRUG: Endocrine Therapy and a CDK 4/6 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apatinib Combined With SOX Neoadjuvant Therapy for Locally Advanced Gastric Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Apatinib Combined|SOX|Neoadjuvant Therapy|Locally Advanced Gastric Cancer
Interventions: DRUG: ApatinibMesylateTablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Autologous Lymphocytes, Cyclophosphamide, and Aldesleukin in Treating Patients With Metastatic Melanoma
Status: TERMINATED
Conditions: Stage IV Melanoma
Interventions: BIOLOGICAL: therapeutic autologous lymphocytes|BIOLOGICAL: aldesleukin|DRUG: cyclophosphamide|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of rTMS on Food Choice in Anorexia Nervosa
Status: SUSPENDED
Conditions: Anorexia Nervosa
Interventions: DEVICE: High-frequency repetitive transcranial magnetic stimulation (active rTMS)|DEVICE: Sham repetitive transcranial magnetic stimulation (sham rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lorazepam for the Analgosedation of Pediatric Patients in Mechanical Ventilation.
Status: UNKNOWN
Conditions: Analgesia
Interventions: DRUG: Lorazepam 4 mg/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Relative Bioavailability Study of Bicalutamide 50 mg Tablet and Casodex Following a 50 mg Dose in Healthy Subjects Under Fasting Conditions
Status: COMPLETED
Conditions: Prostate Cancer|Hirsutism
Interventions: DRUG: Bicalutamide 50 mg Film-Coated Tablets (Casodex) (Astrazeneca Pharmaceutical LP, USA)|DRUG: Bicalutamide 50 mg Film-Coated Tablets (Sandoz Inc., USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Keratoconus
Interventions: DEVICE: Corneal Collagen Crosslinking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Oral Cladribine in Subjects With Relapsing-remitting Multiple Sclerosis (RRMS)
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Cladribine 5.25 mg/kg|DRUG: Cladribine 3.5 mg/kg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Recombinant LH Supplementation Timing Strategies (From Day 1 or Day 6) to a Standard GnRH Agonist Long Protocol in Subsequent COS Cycle of Older Patients With Unexpected Poor or Suboptimal Ovarian Response
Status: UNKNOWN
Conditions: Infertility,Female
Interventions: DRUG: rLH|DRUG: rLH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study to Evaluate the Safety of Sotagliflozin in Patients With Type 1 Diabetes Who Have Inadequate Glycemic Control With Insulin Therapy Alone
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus (T1DM)|High Level of Sugar (Glucose) in the Blood
Interventions: DRUG: Sotagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Placebo- and Active Comparator-controlled Study to Evaluate the Photosafety of SAR441566
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: SAR441566|DRUG: Placebo|DRUG: Ciprofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Evaluation of Default Access to Palliative Services
Status: COMPLETED
Conditions: COPD|ESRD|Dementia
Interventions: BEHAVIORAL: Default ordering of palliative consult
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Oral Ketones and Exercise Among Patients With Long-chain Fatty Acid Oxidation Disorders
Status: COMPLETED
Conditions: Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency|Carnitine Palmitoyltransferase Deficiency 2|Very Long Chain Acyl Coa Dehydrogenase Deficiency|Trifunctional Protein Deficiency
Interventions: DIETARY_SUPPLEMENT: Nutritional Ketone Supplement|DIETARY_SUPPLEMENT: Isocaloric Placebo Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors
Status: COMPLETED
Conditions: Childhood Atypical Teratoid/Rhabdoid Tumor|Childhood Central Nervous System Germ Cell Tumor|Childhood Choroid Plexus Tumor|Childhood Craniopharyngioma|Childhood Ependymoblastoma|Childhood Grade I Meningioma|Childhood Grade II Meningioma|Childhood Grade III Meningioma|Childhood High-grade Cerebellar Astrocytoma|Childhood High-grade Cerebral Astrocytoma|Childhood Infratentorial Ependymoma|Childhood Low-grade Cerebellar Astrocytoma|Childhood Low-grade Cerebral Astrocytoma|Childhood Medulloepithelioma|Childhood Mixed Glioma|Childhood Oligodendroglioma|Childhood Supratentorial Ependymoma|Recurrent Childhood Brain Stem Glioma|Recurrent Childhood Brain Tumor|Recurrent Childhood Cerebellar Astrocytoma|Recurrent Childhood Cerebral Astrocytoma|Recurrent Childhood Ependymoma|Recurrent Childhood Medulloblastoma|Recurrent Childhood Pineoblastoma|Recurrent Childhood Spinal Cord Neoplasm|Recurrent Childhood Subependymal Giant Cell Astrocytoma|Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor|Recurrent Childhood Visual Pathway and Hypothalamic Glioma
Interventions: DRUG: veliparib|DRUG: temozolomide|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KiteLock 4% EDTA Lock Solution for the Prevention of Occlusions in Children With Intestinal Failure
Status: RECRUITING
Conditions: Pediatric Intestinal Failure
Interventions: DEVICE: KiteLock 4% Sterile Catheter Lock Solution|DEVICE: Heparin Lock Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Aliskiren and Hydrochlorothiazide on Kidney Oxygenation in Patients With Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Aliskiren|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quality Control of Esophagogastroduodenoscopy Using Real-time EGD Auxiliary System
Status: COMPLETED
Conditions: Esophagogastroduodenoscopy
Interventions: OTHER: automatic quality-control system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of Walk With Ease in Arthritis
Status: COMPLETED
Conditions: Arthritis
Interventions: BEHAVIORAL: Walk with Ease - Group|BEHAVIORAL: Walk with Ease - Self
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pexidartinib in Participants With Moderate Hepatic Impairment Compared With Healthy Participants
Status: COMPLETED
Conditions: Moderate Hepatic Impairment
Interventions: DRUG: Pexidartinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial)
Status: RECRUITING
Conditions: Anesthesia|Propofol Adverse Reaction|Etomidate Adverse Reaction|Anesthesia Complication|Anesthesia; Adverse Effect|Anesthesia; Reaction
Interventions: DRUG: Admixture of propofol and etomidate at a ratio by volume of 75%/25% (P7E2)|DRUG: Admixture of propofol and etomidate at a ratio by volume of 25%/75% (P2E7)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Lymphatic Organs and Myocardium After Myocardial Infarction
Status: RECRUITING
Conditions: Myocardial Infarction|Myocardial Injury|Myocardial Inflammation
Interventions: DIAGNOSTIC_TEST: Multimodality Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety Study of CC-93538 in Adult and Adolescent Participants With Eosinophilic Esophagitis
Status: RECRUITING
Conditions: Eosinophilic Esophagitis
Interventions: DRUG: CC-93538
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Strategy of Improving Treatment Outcome and Larynx-preservation Rate in Locally Advanced Hypopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Hypopharyngeal Cancer
Interventions: DRUG: Induction CT+ CRT group|RADIATION: Concurrent CRT group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Analgesic Effect and Prognosis of Butorphanol and Fentanyl in Patients With Mechanical Ventilation
Status: UNKNOWN
Conditions: Analgesia
Interventions: DRUG: Butorphanol and Propofol|DRUG: Fentanyl and Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: 90Second IBD for the Improvement of Self Efficacy and Quality of Life in Inflammatory Bowel Disease Patients
Status: RECRUITING
Conditions: IBD|Crohn Disease|Ulcerative Colitis
Interventions: OTHER: 90Second IBD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Linking Novel Diagnostics With Data-Driven Clinical Decision Support in the Emergency Department
Status: UNKNOWN
Conditions: Inpatient Hospitalization, Intensive Care Unit Admission, Inpatient Mortality, Sepsis and Septic Shock
Interventions: OTHER: TriageGO-MDW Clinical Decision Support|OTHER: Usual Care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Familiar Fatal Insomnia: Preventive Treatment With Doxycycline in Subject With Disease Risk
Status: COMPLETED
Conditions: Familial Fatal Insomnia
Interventions: DRUG: Doxycycline Hcl|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Early Treatment With Ivermectin and LosarTAN for Cancer Patients With COVID-19 Infection
Status: TERMINATED
Conditions: Cancer|COVID|Coronavirus Infection
Interventions: DRUG: Placebo|DRUG: Ivermectin|DRUG: Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Metformin, Dapagliflozin, Combination of Metformin and Pioglitazone in Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Type2diabetes|Insulin Resistance
Interventions: DRUG: Metformin|DRUG: Dapagliflozin|DRUG: Fixed-dose combination of metformin and pioglitazone (500mg metformin plus 15mg pioglitazone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: POWER Myocardial Fatigue Study: a Biomechanical Assessment of Contractility of Human Myocardium
Status: RECRUITING
Conditions: Heart Failure|Fatigue; Muscle, Heart|Myocardial Dysfunction|Exhaustion; Heart
Interventions: OTHER: In-vitro contractile fatigue protocol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clopidogrel Monotherapy in Patients With High Bleeding Risk
Status: COMPLETED
Conditions: Bleeding Complications
Interventions: DRUG: Clopidogrel|DRUG: Prasugrel|DRUG: Tricagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SH229 Tablets Combined With Daclatasvir Dihydrochloride Tablets in Treatment Adult Patients With Chronic Hepatitis C
Status: UNKNOWN
Conditions: Hepatitis C, Chronic
Interventions: DRUG: SH229 tablets|DRUG: Daclatasvir dihydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantitative and Clinical Assessment of Flexor Tendon Gliding Following Application of a Bioresorbable Hydrogel: A Prospective, Randomized Study in Patients Undergoing Distal Radius Fracture Repair
Status: RECRUITING
Conditions: Distal Radius Fracture|Tendon Rupture
Interventions: DEVICE: Versawrap membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Spinal COrd NeuromodulaTor by SpIneX and ScoNE to Treat NeurogeniC BladdEr - SCONE "CONTINENCE" Clinical Study
Status: RECRUITING
Conditions: Neurogenic Bladder|Spinal Cord Injuries (Complete and Incomplete)|Stroke|Multiple Sclerosis
Interventions: DEVICE: SCONE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dienogest Versus GnRH-a Pre-treatment in Women With Endometriosis Undergoing IVF
Status: UNKNOWN
Conditions: Endometriosis
Interventions: DRUG: Dienogest 2 MG|DRUG: gonapeptyl|PROCEDURE: IVF/IVF+ART
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound in Detecting Taxane-Induced Neuropathy in Patients With Breast Cancer
Status: COMPLETED
Conditions: Peripheral Neuropathy|Stage 0 Breast Cancer|Stage I Breast Cancer|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage II Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage III Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer
Interventions: PROCEDURE: Biopsy|OTHER: Questionnaire Administration|DIAGNOSTIC_TEST: Ultrasound Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: RObotic-assisted Versus Conventional Knee Endoprosthetic Techniques
Status: RECRUITING
Conditions: Knee Arthroplasty, Total|Robotic-assisted|Osteoarthritis of the Knee
Interventions: PROCEDURE: Patients will be randomized to undergo TKR or RTKR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LMB-9 Immunotoxin in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Bladder Cancer|Breast Cancer|Colorectal Cancer|Esophageal Cancer|Gastric Cancer|Lung Cancer|Pancreatic Cancer
Interventions: BIOLOGICAL: LMB-9 immunotoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Assessment of Vardenafil in Patients With Erectile Dysfunction in Asia
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Vardenafil (Levitra, BAY38-9456)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2b Study of ALN-RSV01 in Lung Transplant Patients Infected With Respiratory Syncytial Virus (RSV)
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: DRUG: ALN-RSV01|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Post Operative Pain Following Indirect Pulp Capping Using Antibacterial Bonding System
Status: COMPLETED
Conditions: Deep Caries
Interventions: PROCEDURE: Indirect pulp capping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of FAECC Scale (Modified FLACC) to Evaluate Ear Pain in Children With Acute Otitis Media
Status: COMPLETED
Conditions: Pain|Otitis Media
Interventions: DRUG: benzocaine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Transcorneal Electrical Stimulation (TES) for the Treatment of Amblyopia
Status: UNKNOWN
Conditions: Amblyopia
Interventions: DEVICE: OkuStim®|DEVICE: Sham-OkuStim®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Single Doses of ILV-095 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: BIOLOGICAL: ILV-095|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Inhaled Alpha-1 Antitrypsin in Preventing Bronchiolitis Obliterable Syndrome in Lung Transplant Recipients
Status: UNKNOWN
Conditions: Lung Transplantation|Bronchiolitis Obliterable Syndrome
Interventions: DRUG: Alpha -1 Antitrypsin|DRUG: Alpha-1 Antitrypsin|DRUG: AAT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Immunogenicity of Meningococcal C Conjugate Vaccine to Children 32 to 40 Months of Age
Status: COMPLETED
Conditions: Meningococcal Infection
Interventions: BIOLOGICAL: Meningococcal C conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Losartan, Pembrolizumab and Stereotactic Body Radiation Therapy for the Treatment of Patients With Locally Recurrent, Refractory or Oligometastatic Head and Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Locally Recurrent Head and Neck Squamous Cell Carcinoma|Metastatic Head and Neck Squamous Cell Carcinoma|Refractory Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Losartan|BIOLOGICAL: Pembrolizumab|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Non-Dialysis (ASCEND-ND)
Status: COMPLETED
Conditions: Anaemia
Interventions: DRUG: Daprodustat|DRUG: Darbepoetin alfa|DRUG: Placebo|DRUG: Iron Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dual Use of ENDS and Combustible Cigarettes
Status: RECRUITING
Conditions: Smoking, Cigarette|Electronic Cigarette Use
Interventions: BEHAVIORAL: Cue Reactivity Task|BEHAVIORAL: Computerized Visual Dot Probe|BEHAVIORAL: Choice Task
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of SVV Guided Fluid Therapy on Blood Loss and Postoperative Outcomes
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: OTHER: crystalloid|OTHER: colloid|OTHER: mannitol|OTHER: lasix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Korean Red Ginseng in Treating Patients With Fatigue Caused by Chemotherapy for Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: Korean Red Ginseng|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetics of Peginterferon Alfa-2b in Participants With Moderate and Severe Renal Impairment (P05655)
Status: COMPLETED
Conditions: Renal Insufficiency
Interventions: DRUG: PegIFN-2b (Sylatron®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Standard Bupivacaine vs Liposomal Bupivacaine in Colorectal Patients
Status: TERMINATED
Conditions: Opioid Use|Pain, Postoperative|Colectomy|Colorectal Surgery
Interventions: DRUG: Bupivacaine|DRUG: Bupivacaine liposome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Anterior Zirconia vs. Resin Strip Crowns
Status: COMPLETED
Conditions: Caries, Dental
Interventions: DEVICE: Resin strip crowns|DEVICE: Zirconia crowns
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vascular Closure With a Device Compared to Manual Compression After Atrial Fibrillation Ablation: The LockeT II Study
Status: RECRUITING
Conditions: Atrial Fibrillation|Hemostasis
Interventions: DEVICE: Vascular closure with LockeT device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Artificial Intelligence on Nutritional Status of Children Post Cardiac Surgery
Status: COMPLETED
Conditions: Post-cardiac Surgery
Interventions: DEVICE: mobile based application|BEHAVIORAL: Pamphlet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Comparison of Tolterodine and Placebo Treatments on Nocturnal Frequency and Sleep Quality in Women After Menopause.
Status: TERMINATED
Conditions: Urinary Incontinence
Interventions: DRUG: tolterodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Avenanthramide and Saponin Bioavailability in Oat Bran
Status: COMPLETED
Conditions: Human Health|Polyphenols|Pharmacokinetics
Interventions: DIETARY_SUPPLEMENT: Oat Bran Consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination Chemotherapy Plus Radiation Therapy in Treating Children With Newly Diagnosed Brain Stem Glioma
Status: COMPLETED
Conditions: Brain Tumors|Central Nervous System Tumors
Interventions: DRUG: etoposide|DRUG: vincristine sulfate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Efficacy of Disulfiram and Copper Gluconate in Recurrent Glioblastoma
Status: COMPLETED
Conditions: Recurrent Glioblastoma
Interventions: DRUG: Disulfiram/Copper|DRUG: Temozolomide (TMZ)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Performance of Diuretic Stress Test in Predicting Short Term Renal Recovery in Oliguric Critically-ill Patients Recovery in the Short Term
Status: TERMINATED
Conditions: Critical Illness|Oliguria
Interventions: DRUG: Furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Integrating Lonely Elderly Patients in Workshops in a Cartoon Museum: An Efficacy Study
Status: UNKNOWN
Conditions: Quality of Life|Social Isolation|Loneliness
Interventions: BEHAVIORAL: Information, event and workshops at a cartoon museum|BEHAVIORAL: Information and event at a cartoon museum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Two Exercise Training Programs to Reduce Leg Pain in People With Peripheral Arterial Disease (The EXERT Study)
Status: COMPLETED
Conditions: Intermittent Claudication|Peripheral Vascular Diseases
Interventions: BEHAVIORAL: Treadmill Exercise Training|BEHAVIORAL: Arm Ergometry Exercise Training|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Neoadjuvant Short Course IMRT Followed by Surgery and IORT for Resectable Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Neoplasms
Interventions: RADIATION: neoadjuvant short course IMRT|RADIATION: IORT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Letrozole Pretreatment With Misoprostol Induction of Abortion In First-Trimester Missed Miscarriage
Status: UNKNOWN
Conditions: Missed Abortion
Interventions: DRUG: letrozole then misoprostol|DRUG: placebo then misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Promoting Exclusive Breastfeeding Among HIV Infected Women in a PMTCT Program
Status: COMPLETED
Conditions: HIV-infection/Aids|Breast Feeding
Interventions: BEHAVIORAL: Family member / peer support|BEHAVIORAL: Enhanced intervention with counselor support|BEHAVIORAL: standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)
Status: RECRUITING
Conditions: Weight Loss|Metabolic Syndrome|Diabetes Mellitus, Type 2|Central Obesity|Insulin Resistance|Glucose Intolerance|Metabolic Glucose Disorders
Interventions: DEVICE: Continuous Glucose Monitor Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety of HEMOBLAST Bellows in Spine Surgery
Status: COMPLETED
Conditions: Surgical Bleeding
Interventions: DEVICE: HEMOBLAST™ Bellows|DEVICE: absorbable gelatin sponge with thrombin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of PCI-32765 Combined With Fludarabine/Cyclophosphamide/Rituximab (FCR) and Bendamustine/Rituximab (BR) in Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: B-cell Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: PCI-32765
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimizing Nausea and Vomiting During Spinals for CS
Status: TERMINATED
Conditions: Nausea|Vomiting
Interventions: DRUG: Glycopyrrolate|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Umbilical Cord Clamping Time in the Newborn
Status: COMPLETED
Conditions: Anemia Neonatal|Polycythemia Secondary|Hyperbilirubinemia, Neonatal
Interventions: PROCEDURE: ECC|PROCEDURE: DCC|PROCEDURE: Blood Test 6hours|PROCEDURE: Blood Test 24hours|PROCEDURE: Blood Test 48hours|PROCEDURE: Blood Test 28days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Air Optix® Night and Day® Aqua Therapeutic Wear
Status: ENROLLING_BY_INVITATION
Conditions: Bullous Keratopathy|Corneal Erosion|Entropion|Corneal Edema|Corneal Dystrophy
Interventions: DEVICE: Lotrafilcon A contact lenses|DEVICE: Balafilcon A contact lenses
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Safety and Efficacy of OnabotulinumtoxinA to the Depressor Anguli Oris
Status: NOT_YET_RECRUITING
Conditions: Aging
Interventions: DRUG: OnabotulinumtoxinA 50 UNT [Botox Cosmetic]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Enhanced Transcutaneous Delivery of Betamethasone for the Treatment of Vitiligo
Status: RECRUITING
Conditions: Vitiligo
Interventions: OTHER: Enhanced Transcutaneous Delivery of Topical Betamethasone after the treatment with Tixel|OTHER: Topical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Exercise and Education in Pain Neurophysiology to Improve Pain Intensity in Women With Endometriosis. Clinical Trial.
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometriosis
Interventions: OTHER: Therapeutic exercise AND pain neurophysiology education|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex Disease in Patients With AIDS: Open Label Pilot Study of Topical Trifluridine
Status: COMPLETED
Conditions: Herpes Simplex|HIV Infections
Interventions: DRUG: Trifluridine|DRUG: Bacitracin zinc/Polymyxin B sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Auricular Vagus Nerve Stimulation on EEG and EMG Measurement in Healthy Persons
Status: COMPLETED
Conditions: Vagus Nerve Stimulation|Electromyography|Electroencephalography
Interventions: DEVICE: Bilateral Auricular Vagus Nerve Stimulation will be performed with a device called VAGUSTIM.|DEVICE: Unilateral-Right Auricular Vagus Nerve Stimulation will be performed with a device called VAGUSTIM.|DEVICE: Unilateral-Left Auricular Vagus Nerve Stimulation will be performed with a device called VAGUSTIM.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Absorption of Zinc (Zn) From Zn-biofortified and Zn-fortified Maize in Young Zambian Children Between 24-36 Months
Status: COMPLETED
Conditions: Nutritional Deficiency
Interventions: OTHER: Biofortified Maize|OTHER: Fortified Maize|OTHER: Control Maize
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Combined Segmentectomy Versus Lobectomy for Stage IA Lung Adenocarcinoma With Ground-glass Component of Prospective, Randomized, Controlled Clinical Study
Status: ACTIVE_NOT_RECRUITING
Conditions: IA Lung Adenocarcinoma|Combined Segmentectomy
Interventions: PROCEDURE: Patients receive subsegmentectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Myocardial Tomoscintigraphies Using a Semiconductor Camera or a Conventional Camera
Status: COMPLETED
Conditions: Myocardial Infarction|Ischemia
Interventions: OTHER: Stress thallium-201 tomoscintigraphy, followed by a second rest tomoscintigraphy if necessary|OTHER: Rest technetium-99m tomoscintigraphy followed by stress technetium-99m tomoscintigraphy on the same day|OTHER: Stress technetium-99m tomoscintigraphy followed by rest technetium-99m tomoscintigraphy on the same day|OTHER: stress technetium-99m tomoscintigraphy followed by rest technetium-99m tomoscintigraphy in two different days|OTHER: Rest thallium-201 tomoscintigraphy with gamma-camera and D.SPECT camera|OTHER: Rest technetium-99m tomoscintigraphy with gamma-camera and D.SPECT camera
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Multicenter Study of Pulsed Field Ablation for Paroxysmal Supraventricular Tachycardia
Status: ACTIVE_NOT_RECRUITING
Conditions: Paroxysmal Supraventricular Tachycardia
Interventions: DEVICE: Pulsed Field Ablation Device and Force Sensing Pulsed Field Ablation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxyurea With or Without Imatinib Mesylate in Treating Patients With Recurrent or Progressive Meningioma
Status: UNKNOWN
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: hydroxyurea|DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing a Resiliency Intervention to Support Healthcare Workers Engaged in the Provision of HIV Care
Status: NOT_YET_RECRUITING
Conditions: Stress|Burnout, Professional
Interventions: BEHAVIORAL: Adapted Relaxation Response Resiliency Program (3RP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Ceftaroline Fosamil vs Vancomycin Plus Aztreonam in the Treatment of Patients With Skin Infections.
Status: TERMINATED
Conditions: Complicated Skin and Soft Tissue Infection
Interventions: DRUG: Ceftaroline fosamil|DRUG: Vancomycin|DRUG: Aztreonam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: C1-INH Compared to Placebo at the Time of Prodromal Symptoms for Hereditary Angioedema (HAE) Exacerbation
Status: WITHDRAWN
Conditions: Hereditary Angioedema
Interventions: DRUG: C-1-esterase|DRUG: C-1-esterase|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of the PRISM-care Multidisciplinary Oncology Program on Secured Drug Intake of Patients With Kidney Cancer
Status: UNKNOWN
Conditions: Metastatic Renal Cell Carcinoma
Interventions: BEHAVIORAL: PRISM care program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tolerability of Metoprolol-Succinate-ER and Carvedilol in COPD
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|Asthma|Adverse Effect of Beta-adrenoreceptor Antagonists
Interventions: DRUG: Metoprolol succinate ER|DRUG: Carvedilol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Energy Shock Wave Therapy and Non-Muscle Invasive Bladder Cancer
Status: UNKNOWN
Conditions: Non-Muscle Invasive Bladder Cancer
Interventions: DEVICE: Low Energy Shock Wave Treatment|DEVICE: Sham Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Combined Implementation of Dural Puncture Epidural and Programmed Intermittent Epidural Bolus for Labor Analgesia
Status: COMPLETED
Conditions: Labor Pain|Labor Analgesia
Interventions: OTHER: EPL and CEI|OTHER: DPE and CEI|OTHER: DPE and PIEB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficiency of Xanthan Hydrogels Containing Local Anesthetics Encapsulated in Nanostructured Lipid Carries
Status: COMPLETED
Conditions: Dental Trauma|Local Anesthesia|Oral Cavity Disease
Interventions: DRUG: Topical anesthetic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Semaglutide 2.4 mg in Patients With Poor Weight-loss
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Diabetes|Metabolic Syndrome
Interventions: DRUG: Semaglutide 3 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single or Repeated Intravenous Administration of umbiliCAl Cord Mesenchymal sTrOmal Cells in Ischemic Cardiomyopathy
Status: RECRUITING
Conditions: Ischemic Heart Disease
Interventions: BIOLOGICAL: umbilical cord-derived mesenchymal stromal cells (UC-MSCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BGP Stent as Bridging Stent in FEVAR
Status: ACTIVE_NOT_RECRUITING
Conditions: Thoracoabdominal Aortic Aneurysm, Without Mention of Rupture|Abdominal Aortic Aneurysm, Without Mention of Rupture
Interventions: DEVICE: BeGraft Peripheral (BGP) Stent Graft System as bridging stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Investigation to Assess Changes in Quality of Life for Individuals With Type 2 Diabetes After Taking a Meal-replacement Shake.
Status: WITHDRAWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DIETARY_SUPPLEMENT: Meal replacement shake
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Quadriceps-sparing Minimally Invasive and Medial Parapatellar Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: PROCEDURE: total knee arthroplastyinstruments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety of Ozanimod Exposure During Pregnancy in Women With Ulcerative Colitis and Their Infants
Status: NOT_YET_RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: Ozanimod|DRUG: Conventional therapy|DRUG: Advanced therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of ARTISS for Flap Adherence in Abdominoplasty
Status: COMPLETED
Conditions: Seroma|Hematoma
Interventions: BIOLOGICAL: FS VH S/D 4 s-apr (= two-component fibrin sealant, double virus inactivated, made from pooled human plasma)|PROCEDURE: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Lifestyle and Empowerment Techniques in Survivorship of Gynecologic Oncology Study
Status: RECRUITING
Conditions: Gynecologic Cancer|Gynecologic Neoplasm|Ovarian Cancer|Endometrial Cancer|Cervical Cancer|Vulvar Cancer
Interventions: OTHER: LETSGO follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Intravenous Lidocaine on THBS2 and Angiogenic Factors Expression in Women Undergoing Cervical Cancer Surgery
Status: NOT_YET_RECRUITING
Conditions: Cervical Cancer|Metastatic Cancer
Interventions: DRUG: Lidocaine|OTHER: Normal saline (NS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Knee Articular Cartilage Debridement in Conjunction With Partial Meniscectomy
Status: TERMINATED
Conditions: Torn Meniscus
Interventions: DEVICE: Mechanical debridement|DEVICE: Paragon T2|PROCEDURE: Lavage debridement|DEVICE: Mechanical Debridement|DEVICE: RF- based Debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of a Mobile Digital Personal Health Record for Family-Centered Care Coordination for Children and Youth With Special Healthcare Needs
Status: ACTIVE_NOT_RECRUITING
Conditions: Children, Only|Children and Youth With Special Healthcare Needs
Interventions: OTHER: Digital personal health record
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Myo-inositol in Preventing Gestational Diabetes in High-risk Pregnant Women
Status: UNKNOWN
Conditions: Gestational Diabetes
Interventions: DIETARY_SUPPLEMENT: inositol + folic acid|DIETARY_SUPPLEMENT: inositol + folic acid|DRUG: Folic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Anti-Tac(Fv)-PE38 (LMB-2) to Treat Cutaneous T-Cell Lymphomas
Status: COMPLETED
Conditions: Lymphoma|T-Cell|Cutaneous
Interventions: BIOLOGICAL: LMB-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Ulcerative Colitis (UC)
Interventions: DRUG: risankizumab|DRUG: placebo for risankizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gestational Sulfadoxine-pyrimethamine and Azithromycin Treatment to Prevent Preterm Birth
Status: ACTIVE_NOT_RECRUITING
Conditions: Malaria|Sexually Transmitted Diseases|Preterm Birth|Pregnancy
Interventions: DRUG: Sulfadoxine-pyrimethamine treatment twice during pregnancy|DRUG: Sulfadoxine-pyrimethamine at 4-week intervals|DRUG: Sulfadoxine-pyrimethamine every 4 weeks + azithromycin twice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Rectosigmoid Resection vs Seromuscular Tumor Shaving in Ovarian Cancer Surgery
Status: RECRUITING
Conditions: Epithelial Ovarian Cancer|Rectosigmoid Cancer Metastatic
Interventions: PROCEDURE: Rectosigmoid resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telmisartan With or Without Hydrochlorothiazide in Patients With Mild-to-moderate Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan|DRUG: Telmisartan/Hydrochlorothiazide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: STEP 1: Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity
Status: COMPLETED
Conditions: Metabolism and Nutrition Disorder|Overweight or Obesity
Interventions: DRUG: Semaglutide|DRUG: Placebo (semaglutide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Individual Bioequivalence of Gabasandoz® Relative to Neurontin® in Healthy Volunteers
Status: COMPLETED
Conditions: Epilepsy and Neuropathic Pain
Interventions: DRUG: Neurontin® (gabapentin) batch A|DRUG: Neurontin® (gabapentin) batch B|DRUG: Gabasandoz® (gabapentin) batch A|DRUG: Gabasandoz® (gabapentin) batch B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of SGN-CD19A for B-Cell Lymphoma
Status: COMPLETED
Conditions: Burkitt Lymphoma|Lymphoma, Follicular|Lymphoma, Large B-Cell, Diffuse|Lymphoma, Mantle-Cell|Precursor B-cell Lymphoblastic Leukemia-Lymphoma
Interventions: DRUG: SGN-CD19A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-articular Autologous Bone Marrow Aspirate Injection for Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: BMA Injection|BIOLOGICAL: BMA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of Diosmin/Hespiridin Combination on the Clinical Outcomes in Patients With Polycystic Ovary Syndrome
Status: NOT_YET_RECRUITING
Conditions: Poly Cystic Ovary Syndrome
Interventions: DRUG: Daflon|DRUG: Combined oral contraceptive|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Cerebrospinal Fluid Gravity Correlation Analysis
Status: NOT_YET_RECRUITING
Conditions: Specific Gravity|Cerebrospinal Fluid
Interventions: DIAGNOSTIC_TEST: Cerebrospinal fluid densitometry|DIAGNOSTIC_TEST: blood routine examination|DIAGNOSTIC_TEST: Blood electrolyte examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p