pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Lifestyle Intervention Program for Women With Gestational Diabetes or Gestational Impaired Glucose Tolerance
Status: COMPLETED
Conditions: Gestational Diabetes
Interventions: BEHAVIORAL: Lifestyle Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of REGN2810 and Ipilimumab in Patients With Lung Cancer
Status: TERMINATED
Conditions: Advanced Non-Small Cell Lung Carcinoma
Interventions: DRUG: SDREGN2810|DRUG: SDREGN2810/ipi|DRUG: HDREGN2810
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chimeric Antigen Receptor T-cells for The Treatment of AML Expressing CLL-1 Antigen
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: CLL-1.CAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Dexmedetomidine on Intraocular Pressure During Scheduled Spine Surgeries
Status: RECRUITING
Conditions: Intraocular Pressure
Interventions: DRUG: Dexmedetomidine|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Carbon-11 Acetate and Fluorine F 18 Sodium Fluoride PET as a Biomarker of Treatment Response in Patients With Hormone Resistant Metastatic Prostate Cancer
Status: WITHDRAWN
Conditions: Hormone-resistant Prostate Cancer|Recurrent Prostate Cancer|Stage IV Prostate Cancer
Interventions: RADIATION: carbon-11 acetate|RADIATION: fluorine F 18 sodium fluoride|PROCEDURE: positron emission tomography|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Gene Therapy After Frontline Chemotherapy in Treating Patients With AIDS-Related Non-Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: AIDS-related Non-Hodgkin Lymphoma|AIDS-related Plasmablastic Lymphoma|AIDS-related Primary Effusion Lymphoma|HIV Infection
Interventions: DRUG: busulfan|BIOLOGICAL: lentivirus vector rHIV7-shI-TAR-CCR5RZ-transduced hematopoietic progenitor cells|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Diverse Mesenchymal Stem Cells Transplantation for Liver Failure
Status: UNKNOWN
Conditions: Liver Failure
Interventions: GENETIC: Conventional plus BM-MSC treatment|GENETIC: Conventional plus UC-MSC treatment|DRUG: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Whether 15 mg Dose of Ketorolac IV is as Effective as a 30 mg Dose.
Status: UNKNOWN
Conditions: Pain|Pain, Postoperative
Interventions: DRUG: Ketorolac Tromethamine|DRUG: Ketorolac Tromethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interactive Web Program and Health Coaching for Prehypertensive Adults
Status: COMPLETED
Conditions: Weight|Blood Pressure
Interventions: BEHAVIORAL: BlipHub mobile-web app|BEHAVIORAL: BlipHub mobile-web app + health coaching|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Valsartan/Amlodipine Combination in Hypertensive Patients Not Controlled With Valsartan Alone
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: valsartan/amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Meconium Aspiration and Tracheal Suctioning-Feasibility Study
Status: WITHDRAWN
Conditions: Meconium Aspiration Syndrome
Interventions: PROCEDURE: Immediate intubation|PROCEDURE: Immediate resuscitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Influence of Mild and Moderate Hepatic Impairment on the Pharmacokinetics, Safety and Tolerability of Various Doses of Afatinib
Status: COMPLETED
Conditions: Liver Diseases|Healthy
Interventions: DRUG: Afatinib|DRUG: Afatinib|DRUG: Afatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Pegylated Recombinant Human Arginase 1 as a Second-line Therapy in Patients With Advanced Liver Cancer
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: pegylated recombinant human arginase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Early Optimization of Brain Oxygenation on Neurological Outcome After Severe Traumatic Brain Injury
Status: COMPLETED
Conditions: Brain Injuries, Traumatic
Interventions: DEVICE: PbtO2 probes|OTHER: No PbtO2 probes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases
Status: RECRUITING
Conditions: Colorectal Cancer Metastatic|Liver Metastases|Colorectal Cancer
Interventions: DRUG: Botensilimab|DRUG: Balstilimab|DRUG: AGEN1423|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the PAS-Port® Proximal Anastomosis System in Coronary Bypass Surgery
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: PAS-Port Automated Proximal Anastomosis System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: MiSaver® Stem Cell Treatment for Heart Attack (Acute Myocardial Infarction)
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: BIOLOGICAL: MiSaver®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Molecular Detection of Antibiotic Resistance and H Pylori Eradication
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Molecular detection of antibiotic resistance|DRUG: standard triple therapy (PPI, amoxicillin, clarithromycin, metronidazole)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab With Abraxane in Patients With Recurrent Ovarian/ Peritoneal Cancer
Status: COMPLETED
Conditions: Epithelial Ovarian Cancer|Primary Peritoneal Carcinoma
Interventions: DRUG: Bevacizumab|DRUG: Abraxane
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ZD4054 (Zibotentan) in Pain-free or Mildly Symptomatic Patients With Prostate Cancer and Bone Metastases Who Have Rising Serum Prostate Specific Antigen (PSA)
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: ZD4054 15 mg|DRUG: Placebo|DRUG: ZD4054 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate LDL-cholesterol Lowering With Inclisiran Compared to Bempedoic Acid in Patients With Atherosclerotic Cardiovascular Disease.
Status: RECRUITING
Conditions: Hypercholesterolemia
Interventions: DRUG: Inclisiran sodium|DRUG: BPA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimizing the Risk for Obesity During Infancy by Extensive Advisory Service
Status: COMPLETED
Conditions: Reduce the Risk of Obesity During Infancy|Reduce the Risk of Insulin Resistance
Interventions: BEHAVIORAL: advisory support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Radiologic Evaluation and Breast Density (READ)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: temporary discontinuation of hormone therapy for 1 month|OTHER: temporary discontinuation of hormone therapy for 2 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Magnesium Versus High Dose Fentanyl in Endotracheal Intubation
Status: COMPLETED
Conditions: Stress Response
Interventions: DRUG: Magnesium sulfate- Fentanyl|DRUG: Fentanyl 4Mcg/kg|DRUG: Fentanyl 2Mcg/kg|DRUG: Lidocaine 1.5 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Soft Tissue Mobilization and Strengthening Exercises in Management of Local Neck Syndrome
Status: COMPLETED
Conditions: Chronic Pain|Neck Pain
Interventions: OTHER: soft tissue mobilization|OTHER: neck isometric strengthening exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Efficacy and Safety of Sericin Hydrogel Sheet Impregnated With Bird's Nest Extract
Status: UNKNOWN
Conditions: Wound|Donor Site Complication|Skin Graft Scar|Scar Conditions and Fibrosis of Skin
Interventions: DEVICE: Sericin hydrogel sheet impregnated with EBN extract|DEVICE: Placebo hydrogel sheet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lenalidomide Therapy After Chemotherapy & Stem Cell Transplant in Treating Chemotherapy Resistan Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Anaplastic Large Cell Lymphoma, ALK-Negative|Recurrent Anaplastic Large Cell Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Mature T- and NK-Cell Non-Hodgkin Lymphoma|Recurrent Non-Hodgkin Lymphoma|Recurrent Transformed Non-Hodgkin Lymphoma
Interventions: PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation|DRUG: Carmustine|DRUG: Cytarabine|DRUG: Etoposide|DRUG: Lenalidomide|DRUG: Melphalan|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurological Effects of Goal-directed Fluid Therapy in Beach Chair Position Shoulder Surgery
Status: COMPLETED
Conditions: Postoperative Cognitive Dysfunction|Anesthesia
Interventions: PROCEDURE: Goal-directed fluid therapy|PROCEDURE: Non goal-directed fluid therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, Pharmacokinetics and Efficacy of SCT-I10A in Patients With Advanced Solid Tumors or Lymphoma
Status: UNKNOWN
Conditions: Advanced Solid Tumors or Lymphoma
Interventions: BIOLOGICAL: SCT-I10A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Paritaprevir/Ritonavir - Ombitasvir, ± Dasabuvir, ± Ribavirin in Patients With Chronic Hepatitis C - An Observational Study in Belgium
Status: COMPLETED
Conditions: Chronic Hepatitis C, Genotype 1 or 4
Interventions: DRUG: Ombitasvir/paritaprevir/ritonavir|DRUG: Dasabuvir|DRUG: Ribavirin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MW150 Stress Kinase Inhibitor in Mild to Moderate Alzheimer's Disease
Status: NOT_YET_RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: MW150|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Inspiratory Muscle Training on Exercise Performance and Quality of Life in Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: theophylline, long acting bronchodilators (LABD) or combined LABD and inhaled steroids according to GOLD recommendations|OTHER: peripheral muscles exercise training|DEVICE: inspiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: AGED Diagnostics Liver Disease Assessment
Status: NOT_YET_RECRUITING
Conditions: NASH With Fibrosis|NAFLD|Healthy
Interventions: DIAGNOSTIC_TEST: AGED Multiple Target Assay in Healthy Controls|DIAGNOSTIC_TEST: AGED Multiple Target Assay in NAFLD Participants|DIAGNOSTIC_TEST: AGED Multiple Target Assay in Fibrosis Participants
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety Study of CD2027 Ointment 3 Microgram Per Gram (mcg/g) Twice Daily Treatment for Adults With at Least Moderate Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: CD2027 Ointment 3 mcg/g, twice daily|DRUG: Vehicle Ointment, twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating A Novel Ibuprofen Formulation In The Treatment Of Dental Pain
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Novel Ibuprofen|DRUG: Acetaminophen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biofeedback and Osteopathic Procedures for Daytime Urinary Incontinence
Status: RECRUITING
Conditions: Urinary Incontinence
Interventions: OTHER: Biofeedback training and Osteopathy procedure|OTHER: Biofeedback training|OTHER: Osteopathy procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A New Surgical-restorative Approach to Treat Gingival Recessions Associated With Non-carious Cervical Lesions (NCCL)
Status: COMPLETED
Conditions: Gingival Recession|Tooth Abrasion
Interventions: PROCEDURE: Connective tissue graft (CTG)|PROCEDURE: CTG plus resin composite restoration|DRUG: sodium dipyrone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Operating Room Nurse Visit Prior to Cardiac Surgery on Patients's Anxiety, Pain and Analgesic Use
Status: UNKNOWN
Conditions: Postoperative Anxiety|Pain|Postoperative Pain Management
Interventions: OTHER: Preoperative visit of the operating room nurse and patient education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Resistance Training in Body Composition and Body Image Perception of Women Throughout the Menstrual Cycle
Status: TERMINATED
Conditions: Body Image Disturbance
Interventions: BEHAVIORAL: EFP|BEHAVIORAL: LFP|BEHAVIORAL: ELP|BEHAVIORAL: LLP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simultaneous Study of the Serum Tryptase Level of the Mother and the Child During Childbirth (TryPla)
Status: UNKNOWN
Conditions: Newborn|Parturient
Interventions: BIOLOGICAL: Blood sampling for tryptase analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fasting Study of Letrozole Tablets 2.5 mg and Femara® Tablets 2.5 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Letrozole Tablets 2.5 mg|DRUG: Femara® Tablets 2.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: VIA Family - Family Based Early Intervention Versus Treatment as Usual
Status: COMPLETED
Conditions: Early Intervention|Child of Impaired Parents|Child|Adolescent|Mental Disorders, Severe|Schizophrenia|Bipolar Disorder|Depressive Disorder, Recurrent|Psychotic Disorders|Parent-Child Relations
Interventions: OTHER: VIA Family intervention|OTHER: Treatment As Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Eribulin Mesylate, Trastuzumab, and Pertuzumab in Women With Metastatic, Unresectable Locally Advanced, or Locally Recurrent HER2-Positive Breast Cancer
Status: TERMINATED
Conditions: HER2-positive Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: Pertuzumab|DRUG: Trastuzumab|DRUG: eribulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Understanding Effects of Cannabis Use and Abstinence on Neural Glutamate Homeostasis
Status: RECRUITING
Conditions: Cannabis Use Disorder
Interventions: DRUG: [18F]FPEB with PET|BEHAVIORAL: Cannabis abstinence
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Intraoperative Nociception Monitoring With Medstorm, Medasense and Anspec-pro During Total Intravenous Anesthesia
Status: TERMINATED
Conditions: Pain Measurement
Interventions: DEVICE: Non-invasive analgesia monitoring with ANSPEC-PRO monitor and MEDSTORM monitor|DEVICE: Non-invasive analgesia monitoring with ANSPEC-PRO monitor and MEDASENSE monitor|DEVICE: Non-invasive analgesia monitoring with MEDSTORM monitor and MEDASENSE monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study
Status: RECRUITING
Conditions: Cancer
Interventions: DRUG: Atezolizumab|DRUG: Bevacizumab|DRUG: Alectinib|DRUG: Cobimetinib|DRUG: Vemurafenib|DRUG: FAP IL2V|DRUG: Venetoclax|DRUG: Enzalutamide|DRUG: Pembrolizumab|DRUG: Sunitinib|DRUG: Niraparib|DRUG: Cabozantinib|DRUG: Pemetrexed|DRUG: Paclitaxel|DRUG: Emactuzumab|DRUG: Rucaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures
Status: RECRUITING
Conditions: Focal Onset Seizures
Interventions: DRUG: XEN1101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Squalamine Lactate Eye Drops in Subjects With Neovascular (Wet) Age-related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Neovascular Age Related Macular Degeneration
Interventions: DRUG: Squalamine lactate|DRUG: Vehicle control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy
Status: COMPLETED
Conditions: Endocrine Dysfunction|Trauma|Brain Injury
Interventions: DRUG: Androgel (Testosterone Gel)|OTHER: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Emtricitabine/Tenofovir Alafenamide Switch Study for Transgender Individuals for HIV Pre-exposure Prophylaxis
Status: ACTIVE_NOT_RECRUITING
Conditions: Hiv|Hormone Therapy
Interventions: DRUG: Emtricitabine / Tenofovir Disoproxil Oral Tablet 200/300 mg|DRUG: Emtricitabine Tenofovir Alafenamide 200/25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Accuracy of Commercially Available Heart Rate Monitors in Athletes
Status: COMPLETED
Conditions: Heart Rate Monitors|Athletes Heart
Interventions: DEVICE: Fitbit Iconic HR and Garmin Vivosmart HR|DEVICE: Fitbit Iconic HR and TomTom Spark 3|DEVICE: Garmin Vivosmart HR and TomTom Spark 3|DEVICE: Fitbit Iconic HR and Apple Watch III|DEVICE: Apple Watch III and Garmin Vivosmart HR|DEVICE: Apple Watch III and TomTom Spark 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Immunogenicity & Safety Study of Combined/Separate Vaccine(s) Against Common Diseases in Infants (2,4,6 Months of Age).
Status: COMPLETED
Conditions: Poliomyelitis|Tetanus|Acellular Pertussis|Hepatitis B|Diphtheria
Interventions: BIOLOGICAL: Study vaccines: IH+Hib-MenC/NVC; Control: IH+Meningitec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of FTY720 Versus Mycophenolate Mofetil (MMF, Roche Brand) in de Novo Adult Renal Transplant Recipients
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: FTY720
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Comparison of Pilates With Cognitive Functional Therapy in Adults With Chronic Neck Pain
Status: RECRUITING
Conditions: Chronic Neck Pain
Interventions: OTHER: Pilates|OTHER: Cognitive Functional Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assesment of the Endotracheal Tube Cuff Pressure Values in ICU Pateints Before and After Training Seminar
Status: COMPLETED
Conditions: Respiratory Tract Diseases|Respiratory Tract Infections|Pneumonia, Ventilator-Associated|Ventilator-Induced Lung Injury
Interventions: OTHER: traning seminar
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Determination Of Predictive Factors Allowing To An Additional 10% Reduction Of Intra-Ocular Pressure
Status: COMPLETED
Conditions: Glaucoma, Primary Open Angle (POAG)|Ocular Hypertension
Interventions: PROCEDURE: GSS questionnaire|PROCEDURE: IOP|DRUG: LATANOPROST 0.005% / TIMOLOL 0.5% FIXED COMBINATION|PROCEDURE: Visual acuity
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose-ranging Study to Evaluate Albuterol and Hydrofluoroalkane in Subjects Ages 12 and Older With Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Albuterol Spiromax®|DRUG: ProAir® HFA|OTHER: Placebo Inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I-II to Evaluate Efficacy/Safety of Sorafenib+Gemcitabine+Radiotherapy in Locally Advanced Pancreatic Carcinoma
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Gemcitabine|RADIATION: Radiotherapy|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Enzastaurin Versus Placebo in the Treatment of Patients With Brain Metastases of Lung Cancer, After Whole Brain Radiation Therapy
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer|Small Cell Lung Cancer
Interventions: DRUG: enzastaurin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of BYM338 for the Treatment of Unintentional Weight Loss in Patients With Cancer of the Lung or the Pancreas
Status: COMPLETED
Conditions: Cachexia
Interventions: DRUG: BYM338 active drug|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Selinexor With Combination Chemotherapy in Treating Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Cytarabine|DRUG: Mitoxantrone Hydrochloride|DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Assertive Community Treatment on Schizophrenic Patients
Status: COMPLETED
Conditions: Schizophrenia
Interventions: COMBINATION_PRODUCT: Assertive community treatment|COMBINATION_PRODUCT: Basic public health services.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Core Stability Training in Children With Adolescent Idiopathic Scoliosis
Status: COMPLETED
Conditions: Adolescent Idiopathic Scoliosis
Interventions: OTHER: Home Based Traditional Scoliosis Exercises|OTHER: Core Stability Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Expanded Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk
Status: RECRUITING
Conditions: Mitral Regurgitation
Interventions: DEVICE: HighLife Transcatheter Mitral Valve Replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 6 of 7)
Status: NOT_YET_RECRUITING
Conditions: Exposure to Man-made Visible Light
Interventions: OTHER: Visible light exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: DermACELL in Subjects With Chronic Wounds of the Lower Extremities
Status: COMPLETED
Conditions: Diabetic Foot Ulcer
Interventions: OTHER: DermACELL|OTHER: GraftJacket|OTHER: Conventional Care Dressings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project Health: Enhancing Effectiveness of an Obesity Prevention Program
Status: ENROLLING_BY_INVITATION
Conditions: Overweight and Obesity|Eating Disorders
Interventions: BEHAVIORAL: Project Health|BEHAVIORAL: Response and Attention Training|OTHER: The Weight of the Nation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial of Theracurmin for Patients With Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Theracurmin HP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Duration Between Drainage and Ureteroscopic Lithotripsy
Status: RECRUITING
Conditions: Ureter Stone|Renal Stone|Ureteric Obstruction
Interventions: PROCEDURE: Early ureteroscopy|PROCEDURE: Delayed Ureteroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Pharmacokinetics and Safety of Trastuzumab Emtansine in Chinese Participants With Locally Advanced Inoperable or Metastatic HER2+ Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Trastuzumab Emtansine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fractional Flow Reserve Guided Immediate Versus Staged Complete Myocardial Revascularization in Patients With ST-segment Elevation Myocardial Infarction With Multivessel Disease (Future Study)
Status: RECRUITING
Conditions: ST Elevation Myocardial Infarction
Interventions: DEVICE: PCI-immediate complete revascularisation|DEVICE: PCI-staged complete revascularisation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Ustekinumab in Patients With Moderate to Severe Palmar Plantar Psoriasis
Status: COMPLETED
Conditions: Moderate to Severe Palmar Plantar Psoriasis
Interventions: DRUG: Ustekinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Captivator Tissue Cassettes vs. no Cassettes for Endoscopic Mucosal Resection in Esophageal Carcinoma
Status: COMPLETED
Conditions: Esophageal Neoplasms
Interventions: DEVICE: Captivator cassette|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: COVID-19 Prophylaxis South Africa (COVER HCW)
Status: COMPLETED
Conditions: Covid19|SARS-CoV Infection
Interventions: DRUG: Nitazoxanide|DRUG: Sofosbuvir/Daclatasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Lenvatinib Combined With Tislelizumab and TACE Applied as Neoadjuvant Regimen for the Patients of CNLC Stage IB and IIA Hepatocellular Carcinoma With High-risk Recurrence Factors
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Lenvatinib|Tislelizumab|TACE|Pharmorubicin|Oxaliplatin
Interventions: PROCEDURE: TACE|DRUG: Tislelizumab, Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Home Administration of Pemetrexed as Maintenance Treatment for Advanced Nonsquamous Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Nonsquamous Non-Small Cell Neoplasm of Lung|Non-Small Cell Lung Cancer Metastatic|Non-Small Cell Lung Cancer Stage IIIB
Interventions: DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Clinical Study to Compare the Efficacy, Safety and Immunogenicity of HLX04 and Bevacizumab Combined XELOX or mFOLFOX6 in the First-line Treatment of mCRC
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer (mCRC)
Interventions: DRUG: HLX04 100 mg in 4 ml Injection|DRUG: Avastin 100 mg in 4 ml Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of MDMA on Startle Response
Status: COMPLETED
Conditions: Startle Response
Interventions: DRUG: Placebo|DRUG: Midomafetamine|BEHAVIORAL: Acoustic startle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: IMT Outcomes in Sufferers of Severe Walking Disabilities and Intensive Care Unit Acquired Weakness
Status: RECRUITING
Conditions: Intensive Care Unit Acquired Weakness
Interventions: BEHAVIORAL: Threshold IMT and traditional physical therapy program|BEHAVIORAL: traditional physiotherapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Defining Optimal Settings for Transbronchial Lung Cryobiopsy II: An Ex-Vivo Human Lungs Model Study for Improvement of Specimen Quality
Status: COMPLETED
Conditions: Transbronchial Lung Cryobiopsy
Interventions: DIAGNOSTIC_TEST: Transbronchial Lung Cryobiopsy (TBLC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Vitamin D Intervention Trial in Healthy Chinese, Phase II
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CSF Metabolomics and Glymphatic Function in Patients Receiving VP- Shunt Surgery.
Status: RECRUITING
Conditions: The Association of Postoperative Cognitive Dysfunction With Glymphatic Function and Neuroinflammation|The Association of Postoperative Cognitive Dysfunction With CSF Metabolomic Change
Interventions: DRUG: Dexmedetomidine|DEVICE: anesthesia depth monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study in Healthy Young Women to Investigate the Pharmacodynamics, Pharmacokinetics and Safety of Vilaprisan
Status: COMPLETED
Conditions: Clinical Trial, Phase I
Interventions: DRUG: Vilaprisan (BAY1002670)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: IC14 for Rapidly Progressive Amyotrophic Lateral Sclerosis (ALS)
Status: WITHDRAWN
Conditions: Amyotrophic Lateral Sclerosis
Interventions: BIOLOGICAL: Biologic: IC14 (monoclonal antibody against human CD14)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecularly Tailored Therapy for Patients With Metastatic Cancer of the Esophagus and Stomach
Status: TERMINATED
Conditions: Esophageal Cancer|Gastric Cancer
Interventions: DRUG: Modified FOLFOX6|DRUG: Docetaxel/Capecitabine|DRUG: Cisplatin/Irinotecan|DRUG: Cisplatin/Docetaxel|DRUG: IRI/EPI|DRUG: EPI/Docetaxel|DRUG: Irinotecan/Docetaxel|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antibacterial Photodynamic Therapy as an Adjunctive Treatment on Oral Hygiene in Elderly Persons
Status: NOT_YET_RECRUITING
Conditions: Dental Plaque|Bleeding of Subgingival Space|Oral Complication
Interventions: DEVICE: Lumoral Treatment|BEHAVIORAL: Standard oral hygiene methods
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intravenous Continuous Infusion Heparin on Rates of Venous Thromboembolism in High-Risk, Critically Ill Patients
Status: WITHDRAWN
Conditions: Venous Thromboembolism
Interventions: DRUG: intravenous continuous infusion of heparin (IV UFH)|DRUG: Subcutaneous Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Physician Attire on Patients' Preference of Physician
Status: COMPLETED
Conditions: Malignant Neoplasms of Independent (Primary) Multiple Sites
Interventions: BEHAVIORAL: Video|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Aggressive Treatment of Metabolic Syndrome in Patients Receiving Clozapine for Schizophrenia
Status: TERMINATED
Conditions: Metabolic Syndrome
Interventions: DRUG: Pravastatin, Fenofibrate, Metformin, Orlistat, irbesartan|OTHER: As selected by community physician
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness and Cost-effectiveness of Acupuncture in Managing Chemotherapy-induced Peripheral Neuropathy
Status: COMPLETED
Conditions: Chemotherapy-induced Peripheral Neuropathy
Interventions: PROCEDURE: Acupuncture|PROCEDURE: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OSSEODENSIFICATION BY DENSAH BURS WITH ACTIVATED PLASMA ALBUMIN GEL FOR SINUS LIFTING WITH SIMULTANEOUS IMPLANT PLACEMENT
Status: RECRUITING
Conditions: Bone Loss, Alveolar
Interventions: COMBINATION_PRODUCT: Densah bur in combination with activated plasma albumin gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Immunoglobulin A (IgA) Nephropathy by Angiotensin-Converting Enzyme (ACE) Inhibitor
Status: COMPLETED
Conditions: Glomerulonephritis
Interventions: DRUG: Ramipril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microneedle Patch Study in Healthy Infants/Young Children
Status: COMPLETED
Conditions: Vaccination|Skin Absorption
Interventions: DEVICE: Microneedle Formulation 1|DEVICE: Microneedle Formulation 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by BCMA CAR-T Therapy in Transplant-Ineligible Patients With Primary Plasma Cell Leukemia
Status: RECRUITING
Conditions: Plasma Cell Leukemia
Interventions: BIOLOGICAL: anti-BCMA CAR-T|DRUG: VRD-based regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of Child-oriented Goal-setting in Paediatric Rehabilitation (the ENGAGE Approach)
Status: RECRUITING
Conditions: Neurodevelopmental Disorders
Interventions: PROCEDURE: ENGAGE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: NM32-2668 in Adult Patients With Selected Advanced Solid Tumors
Status: RECRUITING
Conditions: Ovarian Carcinoma|Fallopian Tube Carcinoma|Peritoneal Carcinoma|Endometrial Cancer|Adenocarcinoma of Lung|Triple Negative Breast Cancer|Liposarcoma|Leiomyosarcoma|Mesothelioma, Malignant|Adenocarcinoma - Gastroesophageal Junction (GEJ)|Adenocarcinoma of the Stomach|Melanoma, Malignant|Renal Cell Carcinoma
Interventions: BIOLOGICAL: NM32-2668
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-inferiority Trial Comparing Cloxacillin vs Cefazolin in Methicillin-susceptible Staphylococcus Aureus Bacteremia
Status: ACTIVE_NOT_RECRUITING
Conditions: Bacteremia Due to Methicillin Susceptible Staphylococcus Aureus
Interventions: DRUG: Cloxacillin|DRUG: Cefazolin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Liposomal Annamycin in Patients With Refractory or Relapsed Acute Lymphocytic Leukemia
Status: UNKNOWN
Conditions: Acute Lymphocytic Leukemia
Interventions: DRUG: Liposomal Annamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Deep Brain Stimulation System in Epilepsy: Tracking Neural Excitability
Status: COMPLETED
Conditions: Epilepsy|Nodular Heterotopia
Interventions: DEVICE: Deep Brain Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Trial of Remote Ischemic Pre-conditioning in Vascular Cognitive Impairment
Status: UNKNOWN
Conditions: Vascular Dementia|Cerebral Small Vessel Diseases|Cerebral Small Vessel Ischaemic Disease|Vascular Cognitive Impairment
Interventions: DEVICE: Remote ischemic conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment Strategies in Colorectal Cancer Patients With Initially Unresectable Liver-only Metastases
Status: RECRUITING
Conditions: Colorectal Cancer|Liver Metastases
Interventions: DRUG: FOLFOX/ FOLFIRI with bevacizumab|DRUG: FOLFOXIRI with bevacizumab|DRUG: FOLFOX/ FOLFIRI with panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Positive Airway Pressure as a Potential New Treatment for Cluster Headache
Status: COMPLETED
Conditions: Cluster Headache|Chronic Disease
Interventions: DEVICE: Continuous Positive Airway Pressure|DEVICE: sham Continuous Positive Airway Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Investigation to Evaluate the Safety and Performance of a Treatment Kit for Ingrowing Toenail
Status: COMPLETED
Conditions: Onychomycosis of Toenails
Interventions: DEVICE: Ingrowing Toenail Treatment Kit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modified Vertical Internal Mattress Suture Versus Simple Loop Interrupted Suture.
Status: COMPLETED
Conditions: Healing Surgical Wounds|Periodontitis
Interventions: PROCEDURE: Modified vertical internal mattress sutures + MWF surgery.|PROCEDURE: Simple loop interrupted sutures + MWF surgery.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of CJ-12420 in Patients With Erosive Esophagitis
Status: COMPLETED
Conditions: Erosive Esophagitis|GERD
Interventions: DRUG: CJ-12420|DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Psilocybin for Anorexia in Young Adults
Status: NOT_YET_RECRUITING
Conditions: Anorexia Nervosa
Interventions: DRUG: Psilocybin|BEHAVIORAL: Preparation and Integration Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of Standard and Innovative Products That Represent a Substitute Meal for Weight Management in a Reduction Diet in Obese Participants With Asthma
Status: RECRUITING
Conditions: Obesity|Asthma|Overweight
Interventions: DIETARY_SUPPLEMENT: Meal replacement product- STANDARD PRODUCT|DIETARY_SUPPLEMENT: Meal replacement product- INNOVATIVE PRODUCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Enteral Nutrition Rich in Eicosapentaenoic Acid (EPA) on Patients Receiving Chemotherapy for GI Tumor
Status: UNKNOWN
Conditions: Gastric Cancer|Colorectal Cancer|Chemotherapy
Interventions: DRUG: Nutriall|DRUG: LDEPA|DRUG: Placebo|DRUG: HDEPA|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Clinical Outcome of BiCRI in the Treatment of Chondral and Osteochondral Lesions
Status: RECRUITING
Conditions: Articular Cartilage Disorder of Knee
Interventions: DEVICE: Biphasic Cartilage Repair Implant (BiCRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abaloparatide Before Total Knee Arthroplasty
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoporosis|Arthroplasties, Knee Replacement
Interventions: DRUG: Abaloparatide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Maternal EED Study
Status: RECRUITING
Conditions: Environmental Enteric Dysfunction (EED)|Malnutrition|Women of Reproductive Age|Gut Microbiota|Balanced Energy Protein (BEP)
Interventions: DIETARY_SUPPLEMENT: Microbiota-directed balanced energy protein (MD-BEP)|DIETARY_SUPPLEMENT: Ready-to-use supplementary food-balanced energy protein (RUSF-BEP)|PROCEDURE: Esophagogastroduodenoscopy (EGD)|BEHAVIORAL: Counselling and follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Carmustine Wafers Plus Irinotecan in Treating Patients With Recurrent Supratentorial High Grade Gliomas
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: carmustine|DRUG: irinotecan hydrochloride|DRUG: polifeprosan 20 with carmustine implant|PROCEDURE: surgical procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Low Starch Dietary Education Program vs. Traditional Treatment for PCOS
Status: COMPLETED
Conditions: PCOS|Diet Modification|Metabolism|Nutrition Disorders
Interventions: DRUG: Metformin|OTHER: One-On-One Dietary Instruction|OTHER: Video Dietary Instruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tofacitinib Versus Cyclosporine for Steroid Refractory Acute Severe Ulcerative Colitis
Status: NOT_YET_RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: Tofacitinib|DRUG: Cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT