pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Postoperative Oral Methadone After Major Spine Surgery; Safety, Feasibility and Efficacy in Prevention of Progression to Chronic Opioid Usage at 3 Months
Status: NOT_YET_RECRUITING
Conditions: Spine Surgery
Interventions: DRUG: Postoperative methadone|DRUG: Postoperative placebo|DRUG: Rescue Analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravascular Laser Irradiation of Blood Use in Poor Ovarian Responders
Status: ACTIVE_NOT_RECRUITING
Conditions: Unrecognized Condition
Interventions: OTHER: Intravascular laser irradiation of blood
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial on Combined (Neo-)Adjuvant Intravenous Plus Intracranial Administration of Ipilimumab and Nivolumab in Recurrent Glioblastoma
Status: NOT_YET_RECRUITING
Conditions: Recurrent Glioblastoma
Interventions: DRUG: Neo-adjuvant nivolumab and ipililumab IV + adjuvant nivolumab and ipililumab IV|PROCEDURE: Neurosurgery and intracavitary injection nivolumab and ipililumab|DRUG: Adjuvant nivolumab IV + nivolumab and ipililumab intracavitary
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Safety and Immunogenicity of a 20-Valent Pneumococcal Vaccine in Adults 65 Years of Age or Older With Prior Pneumococcal Vaccination
Status: COMPLETED
Conditions: Pneumococcal Disease
Interventions: BIOLOGICAL: 13vPnC|BIOLOGICAL: PPSV23|BIOLOGICAL: 20vPnC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 'The Effect of Adding LFCN Block to PENG
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain, Postoperative|Pain, Acute|Nerve Block|Opioid Consumption
Interventions: PROCEDURE: PENG Block|PROCEDURE: LFCN block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects Of Cervical Mobilization
Status: COMPLETED
Conditions: Stroke|Ischemic Stroke|Chronic Stroke
Interventions: OTHER: manual therapy for cervikal region|OTHER: osteopathic suboccipital myofascial release technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Efficacy and Safety Between IBI308 and Docetaxel in Patients With Advanced or Metastatic NSCLC
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: IBI308|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ozoral Pro and Ozoral Gel vs Chlorhexidine Gel 1% for the Management of Peri-implant Mucositis Sites.
Status: COMPLETED
Conditions: Peri-implant Mucositis
Interventions: OTHER: Ozoral Pro and Ozoral gel administration|OTHER: Curasept chlorhexidine gel 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nexium (Esomeprazole) in Symptom Adapted Therapy in GERD Patients
Status: COMPLETED
Conditions: GERD
Interventions: DRUG: esomeprazole (Nexium®)|DRUG: Xolaam®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Peri-percutaneous Coronary Intervention Oxygenation on Myocardial Protection & Cardiovascular Fitness
Status: COMPLETED
Conditions: Myocardial Ischemia|Cardiovascular Morbidity
Interventions: PROCEDURE: Percutaneous Coronary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Local Anesthesia on Postbronchoscopy Fever: a Randomised Controlled Study
Status: COMPLETED
Conditions: Postoperative Complications
Interventions: OTHER: local surface anesthesia|DEVICE: Laryngeal tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Carter Institute Caregiver Education Program at the VA
Status: COMPLETED
Conditions: Caregivers
Interventions: BEHAVIORAL: Caring For You, Caring For Me|BEHAVIORAL: Caring for you, caring for me + social worker|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Proof of Concept: Socket Seal
Status: TERMINATED
Conditions: Tissue Preservation
Interventions: DEVICE: BioOss® + Mucograft Seal®|OTHER: FGG + Bio-Oss®|OTHER: FGG + Gelatine sponge (Spongostan®)|DEVICE: Spongostan®+ Mucograft® Seal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Minimally Processed Animal Protein on Biomarkers for Cognitive Decline
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Lifestyle
Interventions: OTHER: Red meat-based meal|OTHER: Lacto-ovo-vegetarian meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Investigation of the Effect of Short-term Orthokeratology With Increased Compression Factor on Ocular Parameters
Status: COMPLETED
Conditions: Myopic Progression
Interventions: DEVICE: Orthokeratology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Exercise and Music Combination on Sports Anxiety, Exercise Beliefs, Coping Effectiveness, and Mental Toughness Among Chinese Sports Anxiety College Students
Status: COMPLETED
Conditions: Health|Sports Anxiety|Mental Toughness|Coping Effectiveness|Exercise Beliefs
Interventions: BEHAVIORAL: experiment of music|BEHAVIORAL: experiment of exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Implementation of Academic Detailing Interventions on Prescribing of Antimicrobial Drugs in Primary Health Care
Status: COMPLETED
Conditions: Upper Respiratory Tract Infections|Acute Respiratory Tract Infection|Viral Infection
Interventions: BEHAVIORAL: Academic detailing intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluating Adult Patient Temperatures During Lower Spinal Surgery
Status: COMPLETED
Conditions: Hypothermia
Interventions: DEVICE: Heated Ventilator Circuit|DEVICE: Standard Ventilator Circuit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, Immunogenicity And CPG Dosage Finding Study of Novartis CpG Adjuvanted Flu Vaccine
Status: COMPLETED
Conditions: Influenza Infection
Interventions: BIOLOGICAL: Subunit influenza vaccine|BIOLOGICAL: Adjuvanted influenza vaccine|BIOLOGICAL: Adjuvanted influenza vaccine combined with CpG7909|BIOLOGICAL: Adjuvanted influenza vaccine combine with CpG7909|BIOLOGICAL: Adjuvanted influenza vaccine combine with CpG7909
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Social Skills and Emotion Regulation Training "SSERT" for Trauma in Psychosis
Status: COMPLETED
Conditions: Psychosis|Trauma|Emotion Regulation
Interventions: BEHAVIORAL: Social Skills and Emotion Regulation Training "SSERT"
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Exploratory Clinical Trial on the Safety, Efficacy, and Pharmacokinetics of XKDCT086 (iPD-1-Claudin18.2-CAR-T) in Claudin 18.2 Positive Advanced Solid Malignant Tumors: a Single Center, Single Arm, Dose-increasing Trial
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Chimeric antigen receptor T cell preparation targeting Claudin18.2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Understanding and Intervening With Heavy Drinking Among Patients With HIV and HCV
Status: COMPLETED
Conditions: Alcohol Use Disorder|HIV/AIDS|Hepatitis C|Binge Drinking
Interventions: BEHAVIORAL: Intervention: (Clinician's Guide + HealthCall for HIV/HCV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: How to Ease the Withdrawal of Tranquilizers Among Older Consumers?
Status: COMPLETED
Conditions: Drug Dependence
Interventions: BEHAVIORAL: Psychosocial intervention|BEHAVIORAL: a weekly physician intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Epirubicin/Cytoxan Followed By A Taxane VS. Epirubicin/Taxane As Treatment For Node-Positive Breast Cancer
Status: COMPLETED
Conditions: Adenocarcinoma
Interventions: DRUG: Epirubicin with Cyclophosphamide, followed by a Taxane|DRUG: Epirubicin with a Taxane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SPYRAL HTN-ON MED Study of Renal Denervation With the Symplicity Spyral™ Multi-electrode Renal Denervation System
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension|Vascular Diseases|Cardiovascular Diseases
Interventions: DEVICE: Symplicity Spyral™ multi-electrode renal denervation system|PROCEDURE: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Spinal Stabilization Exercises in Individuals With Transtibial Amputatıon
Status: COMPLETED
Conditions: Amputees|Exercise Training|Physiotherapy|Energy Metabolism
Interventions: OTHER: Exercise BE|OTHER: Exercise BE+SS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Multicomponent Intervention on Lifestyle, Anthropometric Measurements, Glycemic Control and Quality of Life in Patients Obese People With Type II Diabetes
Status: RECRUITING
Conditions: Obesity|Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Group session 1|BEHAVIORAL: Group session 2|BEHAVIORAL: Group session 3|BEHAVIORAL: Group session 4|BEHAVIORAL: Group session 5|BEHAVIORAL: Group session 6|BEHAVIORAL: Group session 7 to 8|BEHAVIORAL: Group session 9|BEHAVIORAL: Control Intervention 1|BEHAVIORAL: Control Intervention 2|BEHAVIORAL: Control Intervention 3|BEHAVIORAL: Control Intervention 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Buprenorphine Disposition and CYP3A
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Buprenorphine Control|DRUG: Buprenorphine + Rifampin|DRUG: Buprenorphine + Grapefruit juice|DRUG: Buprenorphine + Ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase 2 Pilot Trial of Subjects With Complex Non-healing Diabetic Foot Ulcers Treated With Standard Care Plus Cryopreserved Umbilical Cord Allograft (TTAX01)
Status: COMPLETED
Conditions: Non-healing Wound|Non-healing Diabetic Foot Ulcer|Diabetic Foot Infection
Interventions: BIOLOGICAL: TTAX01|PROCEDURE: Surgical resection and debridement|DRUG: Systemic antibiotics|DEVICE: Off-loading
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Budesonide for Non-ventilated Infants at High Risk of Bronchopulmonary Dysplasia: the i-BUD Pilot Study
Status: WITHDRAWN
Conditions: Bronchopulmonary Dysplasia
Interventions: DRUG: Inhaled budesonide|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Nutrition and Exercise Lifestyle Intervention Program Participant Choice Approach
Status: RECRUITING
Conditions: Lifestyle, Healthy|Pregnancy Related|Adherence, Treatment|Nutrition, Healthy|Weight Gain, Maternal
Interventions: BEHAVIORAL: Nutrition and Exercise Lifestyle Intervention Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Total Knee Arthroplasty Robot Assisted With MAKO™ Robotic System Compared to the Conventional Total Knee Arthroplasty by Mechanical Ancillary
Status: UNKNOWN
Conditions: Total Knee Arthroplasty
Interventions: PROCEDURE: Total knee arthroplasty with the Stryker's MAKO™ system|PROCEDURE: Total knee arthroplasty with mechanical ancillary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries
Status: COMPLETED
Conditions: Postoperative Pain|Carpal Tunnel Release|Distal Radius Fracture
Interventions: DRUG: Acetaminophen|DRUG: Ketorolac Tromethamine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous huMNC2-CAR44 or huMNC2-CAR22 T Cells for Breast Cancer Targeting Cleaved Form of MUC1 (MUC1*)
Status: RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: BIOLOGICAL: huMNC2-CAR44 CAR T cells or huMNC2-CAR22 CAR T cells|BIOLOGICAL: huMNC2-CAR44 CAR T cells or huMNC2-CAR22 CAR T cells @ RP2D
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IV and Intrathecal Ketamine in Cesarean Section
Status: NOT_YET_RECRUITING
Conditions: Cesarean Section|Analgesia
Interventions: DRUG: Intrathecal ketamine|DRUG: Intravenous ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Everolimus (RAD001) and Carboplatin in Pretreated Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: RAD001 (Everolimus) in combination with carboplatin|DRUG: RAD001 (Everolimus) in combination with carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide vs Placebo Maintenance Therapy Following Melphalan Prednisone Velcade® Induction Therapy in NDMM
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy
Status: COMPLETED
Conditions: Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Male Breast Cancer|Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma|Recurrent Adenoid Cystic Carcinoma of the Oral Cavity|Recurrent Adult Brain Tumor|Recurrent Basal Cell Carcinoma of the Lip|Recurrent Colon Cancer|Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity|Recurrent Hypopharyngeal Cancer|Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity|Recurrent Laryngeal Cancer|Recurrent Lip and Oral Cavity Cancer|Recurrent Lymphoepithelioma of the Nasopharynx|Recurrent Lymphoepithelioma of the Oropharynx|Recurrent Metastatic Squamous Neck Cancer With Occult Primary|Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity|Recurrent Mucoepidermoid Carcinoma of the Oral Cavity|Recurrent Nasopharyngeal Cancer|Recurrent Non-small Cell Lung Cancer|Recurrent Oropharyngeal Cancer|Recurrent Pancreatic Cancer|Recurrent Paranasal Sinus and Nasal Cavity Cancer|Recurrent Rectal Cancer|Recurrent Renal Cell Cancer|Recurrent Salivary Gland Cancer|Stage IIIA Breast Cancer|Stage IIIA Non-small Cell Lung Cancer|Stage IIIB Breast Cancer|Stage IIIB Non-small Cell Lung Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer|Stage IV Non-small Cell Lung Cancer|Stage IV Pancreatic Cancer|Stage IV Renal Cell Cancer|Stage IVA Colon Cancer|Stage IVA Rectal Cancer|Stage IVA Salivary Gland Cancer|Stage IVB Colon Cancer|Stage IVB Salivary Gland Cancer|Stage IVC Salivary Gland Cancer|Tongue Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: 18F-fludeoxyglucose (18F-FDG)|DRUG: 18F-FPPRGD2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Functional Rehabilitation for Older Patients With Schizophrenia
Status: TERMINATED
Conditions: Schizophrenia|Aging
Interventions: BEHAVIORAL: CBSST+PDA|BEHAVIORAL: Cognitive Behavioral Social Skills Training|BEHAVIORAL: PDA-only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mannitol Brain Relaxation Effect
Status: UNKNOWN
Conditions: Supratentorial Neoplasms
Interventions: DRUG: 0.25g/kgof 20% mannitol|DRUG: 0.5g/kg of 20% mannitol|DRUG: 1.0g/kg of 20% mannitol|DRUG: 1.5g/kg of 20% mannitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Prebiotic-based Snacks on the Gut Microbiota and Perceived 'Satisfaction'
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Nutriose FB06|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pembrolizumab (MK-3475) With Lenvatinib (E7080/MK-7902) vs. Docetaxel in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC) and Progressive Disease (PD) After Platinum Doublet Chemotherapy and Immunotherapy (MK-7902-008/E7080-G000-316/LEAP-008)
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Non-Small Cell Lung Cancer
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Lenvatinib|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Imaging Biomarkers for Muscular Diseases - Multispectral Optoacoustic Imaging in Spinal Muscular Atrophy
Status: COMPLETED
Conditions: Muscular Diseases|Spinal Muscular Atrophy
Interventions: DEVICE: Multispectral Optoacoustic Tomography (MSOT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of a Modern Educational Intervention in Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Neoplasm|Pain
Interventions: OTHER: Standard physical therapy program|OTHER: Modern educational program|OTHER: Traditional biomedical educational program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Basiliximab #2: In-Vivo Activated T-Cell Depletion to Prevent Graft-Versus_Host Disease (GVHD) After Nonmyeloablative Allotransplantation for the Treatment of Blood Cancer
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Acute Lymphocytic Leukemia|Chronic Myelogenous Leukemia|Chronic Lymphocytic Leukemia|Myelodysplasia|Non-Hodgkin's Lymphoma|Hodgkin's Disease|Multiple Myeloma|Myelofibrosis|Anemia, Aplastic|Hemoglobinuria, Paroxysmal
Interventions: DRUG: Basiliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Safety and Efficacy of Commercial Drug Biktarvy in Subjects Known to Have the 184 Resistance Mutation to a Component in Biktarvy
Status: TERMINATED
Conditions: HIV-1-infection
Interventions: DRUG: Biktarvy Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Therapeutic Activity of GI-102 in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Metastatic Solid Tumor
Interventions: DRUG: GI-102|DRUG: GI-102
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topiramate for Treatment of Patients With Borderline Personality Disorder and Alcohol Dependence
Status: WITHDRAWN
Conditions: Alcohol Dependence|Borderline Personality Disorder
Interventions: DRUG: Topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccination Hesitation in Expectant Mothers
Status: ENROLLING_BY_INVITATION
Conditions: Vaccine Hesitation
Interventions: BEHAVIORAL: training on hesitations regarding childhood vaccinations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Food Study of Meloxicam Tablets 15 mg and Mobic® Tablets 15 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Meloxicam Tablets 15 mg|DRUG: Mobic® Tablets 15 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Vaginal Sildenafil Citrate on Endometrial Preparation and Outcome in Frozen Thawed Embryo Transfer Cycles
Status: UNKNOWN
Conditions: Infertility
Interventions: DRUG: sildenafil citrate|DRUG: Estradiol Valerate 2 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Viral Specific T-cells for Treatment of Viral Infections After Solid Organ Transplant
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Organ Transplant|Viral Infection
Interventions: BIOLOGICAL: Viral Specific T-cells (VSTs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strategy for Early Treatment of Exacerbations in COPD: Standing Prescriptions of Advair With a Written Action Plan in the Event of an Exacerbation
Status: COMPLETED
Conditions: COPD|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Double dose of Salmeterol + Fluticasone Propionate|BEHAVIORAL: Self-management education on the use of a self-administered prescription for exacerbation.|DRUG: Self-administered prescription
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Exercise Training on Cardiovascular Health in Middle-aged Women
Status: COMPLETED
Conditions: Menopause|Cardiac Function Impaired|Cardiovascular Diseases|Blood Platelet Disorders|Metabolic Diseases
Interventions: BEHAVIORAL: Spinning
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reirradiation Dose Escalation in Thoracic Cancers
Status: NOT_YET_RECRUITING
Conditions: Thoracic Cancer|Lung Cancer|Esophageal Cancer
Interventions: RADIATION: stereotactic body radiation therapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Use of Multimedia to Enhance Patient and Family Understanding
Status: UNKNOWN
Conditions: The Role of Multimedia on Retention and Comprehension of Key Concepts for Surgical Options in Newly Diagnosed Breast Cancer Patients.
Interventions: OTHER: This group of patients will be exposed to multimedia|OTHER: No Media
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Procedural Yield of Bronchoalveolar Lavage Using Three Different Techniques in Subjects Undergoing Flexible Bronchoscopy
Status: COMPLETED
Conditions: Bronchoalveolar Lavaage|Diffuse Lung Disease
Interventions: PROCEDURE: Bronchoalveolar lavage using wall mount suction|PROCEDURE: Bronchoalveolar lavage using manual suction|PROCEDURE: Bronchoalveolar lavage using manual suction with rubber tubing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Pazopanib Hydrochloride in Treating Patients With Metastatic Urethral Cancer or Bladder Cancer That Has Relapsed or Not Responded to Treatment
Status: COMPLETED
Conditions: Bladder Cancer|Transitional Cell Cancer of the Renal Pelvis and Ureter|Urethral Cancer
Interventions: DRUG: pazopanib hydrochloride|RADIATION: fludeoxyglucose F 18
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Synergistic Effect of Vedolizumab and Pentoxifylline
Status: COMPLETED
Conditions: Crohn Disease
Interventions: DRUG: vedolizumab|DRUG: Pentoxifylline|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Latiglutenase in T1D/CD Patients
Status: TERMINATED
Conditions: Celiac Disease
Interventions: DRUG: Latiglutenase|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of SCTA01, an Anti-SARS-CoV-2 Monoclonal Antibody, in Healthy Chinese Subjects
Status: COMPLETED
Conditions: Coronavirus Disease 2019(COVID-19)
Interventions: BIOLOGICAL: SCTA01|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hydralazine Versus Labetalol for the Management of Hypertensive Disorders of Pregnancy
Status: COMPLETED
Conditions: Hypertension, Pregnancy Induced
Interventions: DRUG: Hydralazine|DRUG: Labetalol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes After Albumin vs Lactated Ringer's Solution in CABG and AVR Procedures
Status: RECRUITING
Conditions: Coronary Artery Bypass Graft Surgery|Aortic Valve Replacement
Interventions: OTHER: Albumin Solution|OTHER: Lactated Ringer's Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Safety, Reactogenicity and Immunogenicity of "EpiVacCorona" Vaccine for the Prevention of COVID-19
Status: COMPLETED
Conditions: Covid19
Interventions: BIOLOGICAL: EpiVacCorona (EpiVacCorona vaccine based on peptide antigens for the prevention of COVID-19)|OTHER: Placebo (sodium chloride bufus, solvent for the preparation of dosage forms for injection 0.9%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Melatonin for Knee Osteoarthritis Patients
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DIETARY_SUPPLEMENT: Melatonin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stanford Center for Back Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Low Back Pain
Interventions: OTHER: Real-Time fMRI|BEHAVIORAL: CBT or MBSR|DEVICE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BI 655066 (Risankizumab) Compared to Placebo in Japanese Patients With Moderate to Severe Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: risankizumab|DRUG: placebo for risankizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma
Status: TERMINATED
Conditions: Acral Lentiginous Malignant Melanoma|Lentigo Maligna Malignant Melanoma|Nodular Malignant Melanoma|Recurrent Melanoma|Solar Radiation-related Skin Melanoma|Stage IV Melanoma|Superficial Spreading Malignant Melanoma
Interventions: DRUG: gamma-secretase/Notch signalling pathway inhibitor RO4929097|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Sterile HemaClear Tourniquet Below Calf Versus Pneumatic Tourniquet at the Thigh for Ankle and Foot Surgery
Status: UNKNOWN
Conditions: Foot Fracture|Ankle Fractures|Ankle Injuries|Foot Injuries and Disorders
Interventions: DEVICE: HemaClear|DEVICE: Pneumatic Tourniquet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison Between Continuous and Intermittent Intraabdominal Analgesia Using Local Anaesthetics
Status: COMPLETED
Conditions: Abdominal Hysterectomy
Interventions: DRUG: PCRA (Intermittent injection)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Use of Dual Imaging Techniques for Detection of Disease in Patients With Head and Neck Cancer
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma|Recurrent Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Panitumumab-IRDye800|OTHER: Indium In 111 Panitumumab|PROCEDURE: Single Photon Emission Computed Tomography|PROCEDURE: Computed Tomography|PROCEDURE: Resection|PROCEDURE: Fluorescence Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Immunochemotherapy, in Vivo Purging, PBSC Mobilization and Autotransplant in Relapsed or Refractory Follicular Lymphoma
Status: COMPLETED
Conditions: Follicular Lymphoma
Interventions: PROCEDURE: Immunochemotherapy, in vivo purging and autrotransplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label Study Investigating of OKN-007 Combined With Temozolomide in Patients With Recurrent Glioblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Malignant Glioma|Brain Glioblastoma
Interventions: DRUG: OKN-007|DRUG: Temozolomide (TMZ)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Bio-creative Therapy for En Masse Retraction of the Maxillary Anterior Teeth
Status: COMPLETED
Conditions: Malocclusion, Angle Class II, Division 1
Interventions: PROCEDURE: Biocreative therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Immunogenicity and Safety of Two 2-dose Human Papillomavirus (HPV) Vaccine Schedules in 9-14 Year Old Girls
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: BIOLOGICAL: GSK Biologicals' HPV vaccine 580299
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Intravenous (IV) Methylnaltrexone Bromide (MNTX) in the Treatment of Post-Operative Ileus (POI)
Status: COMPLETED
Conditions: Post-Operative Ileus (POI)
Interventions: DRUG: Methylnaltrexone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Benoxinate Hydrochloride Eye Drops on The Premature Infant Pain Profile Score During Retinopathy of Prematurity Screening
Status: COMPLETED
Conditions: Retinopathy of Prematurity
Interventions: DRUG: Benoxinate Hydrochloride|DRUG: artificial tear (Sodium Hyaluronate 2 mg/ml) eye drops.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Long Term Outcomes After Vestibular Implantation
Status: NOT_YET_RECRUITING
Conditions: Bilateral Vestibular Hypofunction|Bilateral Vestibular Deficiency|Bilateral Vestibulopathy|Gentamicin Ototoxicity|Aminoglycoside Toxicity|Vestibular Diseases|Sensation Disorders|Labyrinth Diseases|Other Disorders of Vestibular Function
Interventions: DEVICE: Labyrinth Devices MVI™ Multichannel Vestibular Implant System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Prospective, Open Label, Pilot Study of Patient OutcoMes Following Successful TriAl of High Frequency SpInal CorD Stimulation at 10kHz (HF10™) Leading to Permanent Implant Compared to Trial Failure and Standard CarE for the TreatmeNt of Persistent Low BACK Pain of Neuropathic Origin
Status: UNKNOWN
Conditions: Palliative Care
Interventions: DEVICE: Senza Spinal Cord Stimulation system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study on TIL for the Treatment of Advanced Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Treatment Side Effects|Advanced Breast Cancer|Effects of Immunotherapy
Interventions: BIOLOGICAL: Tumor Infiltrating Lymphocytes (TIL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Extra-High Dose Hepatitis B Vaccination Confer Longer Serological Protection in Peritoneal Dialysis Patients?
Status: COMPLETED
Conditions: Peritoneal Dialysis|Renal Disease, End-Stage
Interventions: BIOLOGICAL: Engerix-B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Caffeine Intake on Autonomic Parameters in the Exercise of Strength
Status: COMPLETED
Conditions: Autonomic Nervous System|Cardiovascular Outcomes
Interventions: DIETARY_SUPPLEMENT: Placebo|OTHER: Caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Perioperative Hypothermia and Myocardial Injury After Non-cardiac Surgery
Status: COMPLETED
Conditions: Perioperative Care|Surgery--Complications|Hypothermia; Anesthesia|Myocardial Injury
Interventions: DEVICE: aggressive warming|DEVICE: routine thermal management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety in Imlifidase Desensitized Kidney Tx Patients, Including Two Non-Comparative Reference Cohorts
Status: RECRUITING
Conditions: Kidney Transplantation in Highly Sensitized Patients
Interventions: DRUG: Imlifidase|OTHER: Normal Transplantation Routine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interleukin-12 Following Chemotherapy in Treating Patients With Refractory HIV-Associated Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: recombinant interleukin-12|DRUG: etoposide|DRUG: ifosfamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Extension Study in Patients With Idiopathic Pulmonary Fibrosis Who Completed Protocol AC-052-321/ BUILD 3 / NCT00391443
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Bosentan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRI Study of Radiation-Induced Damage to White Matter and Blood-Brain-Barrier
Status: COMPLETED
Conditions: Brain Neoplasms
Interventions: RADIATION: Whole Brain Irradiation|RADIATION: Partial Brain Irradiation|BEHAVIORAL: Neuropsychological Testing|BEHAVIORAL: Quality of Life Questionnaire|DEVICE: Magnetic Resonance Imaging (MRI) Assessments
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: AIR (Artificial Implant to Restore the Medial Meniscus Function)2 Clinical Investigation
Status: RECRUITING
Conditions: Knee Injuries and Disorders
Interventions: DEVICE: Trammpolin medial meniscus prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficacy and Safety of Anti-PD-1 Antibody BGB-A317 Versus Docetaxel as Treatment in the Second- or Third-line Setting in Participants With NSCLC
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Tislelizumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postpartum Perineal Pain After Obstetric Anal Sphincter Injuries
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain|Postpartum Depression
Interventions: DRUG: Epidural saline + IV saline|DRUG: Epidural morphine 3 mg + IV saline|DRUG: Epidural morphine 3 mg + IV ketamine 0.3 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Quantitative HPV Genotyping in Screening of Anal Intraepithelial Neoplasia in HIV-positive Patients
Status: TERMINATED
Conditions: Human Immunodeficiency Virus
Interventions: DIAGNOSTIC_TEST: HPV genotyping
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sodiumhexametaphosphate as Pulp Capping Material for Primary Teeth
Status: NOT_YET_RECRUITING
Conditions: Pulp Disease, Dental
Interventions: OTHER: Pulp therapy|DRUG: Sodiumhexametaphosphate|OTHER: MTA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study to Evaluate the Efficacy and Safety of the DW0929 in Patients With Primary Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: DW-0929|DRUG: DW-0929|DRUG: DW-0929|DRUG: Rosuvastatin|DRUG: Rosuvastatin|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Tolerability of JCXH-212 Monotherapy and Combined With Toripalimab in the Treatment of Malignant Solid Tumors
Status: RECRUITING
Conditions: Malignant Solid Tumors
Interventions: BIOLOGICAL: JCXH-212 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study for Ideal Positioning of Dialysis Catheter Tip in Pediatric Patients
Status: COMPLETED
Conditions: Dialysis Catheter; Malposition
Interventions: PROCEDURE: Anatomical landmark guided dialysis catheter insertion|PROCEDURE: ECG guided dialysis catheter insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Addressing Pain Through Navigator-Led Palliative Care Optimized for Heart Failure (ADAPT-HF)
Status: RECRUITING
Conditions: Heart Failure NYHA Class III|Heart Failure NYHA Class IV|Chronic Illness
Interventions: BEHAVIORAL: ADAPT HF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Text Messaging to Improve Adherence to Clinic Visits and Reduce Early Resumption of Sexual Intercourse After Male Circumcision
Status: COMPLETED
Conditions: HIV Infections|Acquired Immunodeficiency Syndrome|Circumcision, Male|Patient Compliance|Cellular Phone
Interventions: OTHER: Text Message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ethnic Dance and Screen Time Reduction to Prevent Weight Gain in Latina Girls
Status: COMPLETED
Conditions: Obesity|Overweight|Excessive Weight Gain
Interventions: BEHAVIORAL: after school ethnic dance program - ballet folklorica|BEHAVIORAL: culturally-tailored, home-based screen time reduction|BEHAVIORAL: culturally-tailored health and nutrition education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Low Workload Concept for the Detection of Silent Atrial Fibrillation (AF) and Atrial Fibrillation Burden in Patients at High Risk of AF and Stroke
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation|Arrhythmias, Cardiac|Heart Diseases|Cardiovascular Diseases|Pathologic Processes|Postoperative Complications
Interventions: DEVICE: Smartphone application|DEVICE: Bed sensor|DEVICE: Wrist-worn photoplethysmography (PPG) and accelerometer data logger.|DEVICE: Patch-holter ECG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nutraceuticals and Functional Foods
Status: UNKNOWN
Conditions: Systemic Disease|Skin Diseases|Memory Disorders|Urologic Diseases|Gastrointestinal Diseases|Inflammatory Disease|Pain, Acute|Pain, Chronic|Infective Disorder|Immune System Diseases|Immune Defect
Interventions: DIETARY_SUPPLEMENT: nutraceuticals
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Nutrition Training on Mothers' Nutrition Pattern, Breast Milk and Newborn Intestinal Microbiota
Status: COMPLETED
Conditions: Microbial Colonization|Nutrient Deficiency
Interventions: BEHAVIORAL: Nutrition Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Discharge Conditions of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl
Status: COMPLETED
Conditions: Hemorrhoid|Peri Anal Fistula
Interventions: DRUG: Prilocaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Monitoring Patterns of Prescribing to Identify Changes in Access to ER/LA Opioid Analgesics
Status: UNKNOWN
Conditions: Opioid Related Disorders|Opiate Addiction|Narcotic Abuse|Drug Abuse
Interventions: OTHER: Non-interventional study - retrospective database review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Huntleigh Dopplex DMX Digital Doppler Arterial Waveform With the Gold Standard of Ultrasound Duplex Arterial Waveform
Status: COMPLETED
Conditions: Ultrasonography, Doppler|Peripheral Arterial Disease
Interventions: DIAGNOSTIC_TEST: Doppler ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Diaphragmatic Strengthening Exercises on Diaphragm Muscle Function in Patients With Post Covid-19 Syndrome.
Status: COMPLETED
Conditions: Corona Virus Infection
Interventions: OTHER: diaphragmatic positioning|OTHER: incentive spirometer|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intake in Bioactive Molecules From Natural or Pasteurised Milk on Gut Maturation in Very Premature Newborns
Status: COMPLETED
Conditions: Premature Birth
Interventions: OTHER: blood samples , feces samples|OTHER: blood samples, feces samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: The Effect of Catheter Valve Vs. Standard Catheter Removal in Outpatients
Status: UNKNOWN
Conditions: Urinary Retention
Interventions: PROCEDURE: Use of catheter valve before 'trial removal of catheter'|PROCEDURE: Trial removal of catheter in patients with urinary retention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Functional Action-Observation Training on Gait Ability in Patients With Chronic Stroke
Status: UNKNOWN
Conditions: Stroke
Interventions: OTHER: Functional action observation training|OTHER: General action observation training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Hip Abductor Training in Women With Stress Urinary Incontinence
Status: NOT_YET_RECRUITING
Conditions: Women With Stress Urinary Incontinence
Interventions: OTHER: hip abductors physiotherapy self training|OTHER: Standard pelvic floor muscle training|OTHER: Standard pelvic floor muscle training self training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT