pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Appetite Suppression Effects of an Herbal Combination of Yerba maté, Guarana, Damiana (YGD), and 12 Other Herbal Components, Versus YGD Supplementation Alone
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: Appetite suppressant properties of YGD and A20-50
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Clinical Study on the Treatment of Breast Hyperplasia With Kou Sha Therapy Based on Real World
Status: NOT_YET_RECRUITING
Conditions: Breast Hyperplasia
Interventions: BEHAVIORAL: kou sha|DRUG: Hongjin Xiaojie Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemoradiation Followed by Durvalumab in Poor Risk and/or Elderly Patients With Stage III NSCLC
Status: RECRUITING
Conditions: Stage III Non-small-cell Lung Cancer
Interventions: DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot of the Feasibility of Using the Iron-Chelator Deferiprone on Mild Cognitive Impairment
Status: WITHDRAWN
Conditions: Mild Cognitive Impairment
Interventions: DRUG: Deferiprone|OTHER: Placebo phase
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Single Ascending Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics (PK) of SP-333 Tablets in Healthy Adult Subjects
Status: COMPLETED
Conditions: Exposure
Interventions: DRUG: SP-333
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Prognostic Value Of Lymphocyte Count and Lymphocyte/ Monocyte Ratio in Patients With Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: Hodgkin Lymphoma
Interventions: DIAGNOSTIC_TEST: First analysis: Lymphocyte count > or = 1500 cells per microlitre, second analysis: IPS < 3 and third analysis: Lymphocyte/Monocyte ratio > or = 2.9|DIAGNOSTIC_TEST: First analysis: Lymphocyte count < 1500 cells per microlitre, second analysis: IPS > or = 3 and third analysis: Lymphocyte/Monocyte ratio < 2.9
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nivolumab in Recurrent or Metastatic Salivary Gland Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Salivary Gland Carcinoma|Metastatic Cancer|Recurrent Cancer
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of NT-501 Encapsulated Cell Therapy for Glaucoma Neuroprotection and Vision Restoration
Status: ACTIVE_NOT_RECRUITING
Conditions: Glaucoma
Interventions: DRUG: NT-501 ECT implant|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Venofer (Iron Sucrose Injection USP) in Patients Receiving Peritoneal Dialysis
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Venofer and stable erythropoietin (EPO) regimen|DRUG: stable erythropoietin (EPO) regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blood Glucose Variability and Insulin Action During Menstrual Cycle in Females With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: Follicular Euglycemic clamp|DEVICE: Luteal Euglycemic clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Tranexamic Acid (TXA) in Humerus ORIF
Status: RECRUITING
Conditions: Fracture Humerus
Interventions: DRUG: Tranexamic acid (TXA)|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Pharmacokinetics (Uptake of Drugs by the Body), Safety and Tolerability of AZD4831 in Participants With Severe Renal Impairment and Healthy Volunteers
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: AZD4831
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-escalation Phase 1 to Evaluate the Safety and Efficacy of MG1111 in Healthy Adults
Status: COMPLETED
Conditions: Varicella (Chicken Pox)
Interventions: BIOLOGICAL: MG1111|BIOLOGICAL: VARIVAX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Ultrasling Quadrant Versus Bledsoe ARC Shoulder Brace
Status: WITHDRAWN
Conditions: Shoulder Injuries and Disorders
Interventions: DEVICE: Ultrasling® Quadrant|DEVICE: Bledsoe ARC®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endothelial Function, Lipoproteins, and Inflammation With Low HDL Cholesterol in HIV: ER Niacin Versus Fenofibrate
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: Niacin|DRUG: Aspirin|DRUG: Fenofibrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cannabidiol Effects on Blood Alcohol Level and Intoxication
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: DIETARY_SUPPLEMENT: 200mg Cannabidiol oral solution|DIETARY_SUPPLEMENT: 30mg Cannabidiol oral solution|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: MicroPort® Endoscopic Instrument Control System to Accomplish Robotic-assisted Surgery in Urology
Status: UNKNOWN
Conditions: Robotic Surgical Procedures|Prostatectomy|Nephrectomy
Interventions: PROCEDURE: MicroPort® robot-assisted laparoscopic surgery|PROCEDURE: da Vinci robot-assisted laparoscopic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient-Centered Care for the Older Adult With Hematologic Malignancy
Status: COMPLETED
Conditions: Hematologic Malignancy
Interventions: OTHER: Baseline Geriatric Screening/Assessment|OTHER: Geriatrician Co-Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Comparison of Cataract Lasers Using the Optimedica Catalys Laser and the Alcon LenSx Laser.
Status: COMPLETED
Conditions: Nuclear Sclerosis of the Lens|Posterior Subcapsular Cataract|Cortical Cataract
Interventions: PROCEDURE: Femtosecond Laser Assisted Cataract Surgery w/ Catalys Laser|PROCEDURE: Femtosecond Laser Assisted Cataract Surgery w/ LenSx Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study in Post-menopausal Women With Hormone Receptor Positive, HER2-negative Advanced Breast Cancer
Status: COMPLETED
Conditions: Post Menopausal Breast Cancer
Interventions: DRUG: everolimus|DRUG: exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integration of Buprenorphine Into HIV Clinical Settings - Primary Care Model (PCM)
Status: COMPLETED
Conditions: Buprenorphine|HIV|Drug Abuse|Drug Addiction|Drug Dependence|Drug Use Disorders|Drug Use Disorder|Substance Abuse|Opiate Addiction|Substance-related Disorders
Interventions: OTHER: Services will be provided at one site|OTHER: Services remain dispersed; i.e., not centralized to one-location or provider.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Educational Intervention With or Without Telephone Counseling in Increasing Colorectal Cancer Screening Compliance in Brothers and Sisters of Patients With Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: OTHER: counseling intervention|OTHER: educational intervention|OTHER: study of socioeconomic and demographic variables
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Inoculating Celiac Disease Patients With the Human Hookworm Necator Americanus: Evaluating Immunity and Gluten-sensitivity
Status: COMPLETED
Conditions: Celiac Disease
Interventions: BIOLOGICAL: Necator americanus|OTHER: Sham inoculation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trauma-focused CBT Versus EMDR in the Treatment of Posttraumatic Stress Disorder
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic
Interventions: BEHAVIORAL: Trauma-focused Cognitive Behavior Therapy|BEHAVIORAL: Eye Movement Desensitization and Reprocessing (EMDR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Quick Response Coded Teaching Plan, Patients With Total Knee Replacement
Status: UNKNOWN
Conditions: Total Knee Replacement Surgery|Patient Education
Interventions: OTHER: Patient Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Transvaginal Cholecystectomy Using Endoscopic Assistance
Status: WITHDRAWN
Conditions: Cholelithiasis|Cholecystitis|Biliary Dyskinesia
Interventions: PROCEDURE: cholecystectomy.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Dementia|Hypoxia|Hyperhomocysteinemia|Vitamin B 12 Deficiency|Iron Deficiency|Anemia|TBI|Neurodegenerative Disorders|Alzheimer's Disease|Vascular Dementia|Brain Injuries|Tauopathies|Parkinson's Disease|Lewy Body Dementia|Frontotemporal Dementia|TDP-43 Proteinopathies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dietary Proteins: Metagenomic and Metabolomics Approaches for Human Biomarkers Identification
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Protein supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Investigating a Vaccine Against COVID-19
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronavirus
Interventions: BIOLOGICAL: ChAdOx1 nCoV-19 (Abs 260)|BIOLOGICAL: MenACWY vaccine|BIOLOGICAL: ChAdOx1 nCoV-19 (Abs 260) + 2.2x10^10vp (qPCR) boost|BIOLOGICAL: Two dose MenACWY vaccine|BIOLOGICAL: ChAdOx1 nCoV-19 (qPCR)|BIOLOGICAL: ChAdOx1 nCoV-19 0.5mL prime plus boost|BIOLOGICAL: Two dose MenACWY vaccine min. 4 weeks apart|BIOLOGICAL: Two dose ChAdOx1 nCoV-19/Covishield 0.5mL|BIOLOGICAL: Two dose ChAdOx1 nCoV-19/Covishield 0.25mL & 0.5mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Investigation of the Effect of Mindfulness-Based Stress Reduction Program on in Pregnant Women
Status: ENROLLING_BY_INVITATION
Conditions: Pregnancy Related|Mediation|Depression|Maternal-Fetal Relations
Interventions: OTHER: Mindfulness stress reduction program group
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Comparison in Cervical Epidural Pressure Changes Between Midline and Paramedian Approaches
Status: UNKNOWN
Conditions: Herniated Nucleus Pulposus|Whiplash Injury
Interventions: PROCEDURE: Cervical epidural steroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bacterial Resistance in Patients Receiving Post-Intravitreal Injection Antibiotics
Status: COMPLETED
Conditions: Bacterial Resistance
Interventions: DRUG: Ciprofloxacin|DRUG: Standard Aseptic Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Onabotulinum Toxin A (Botox) for the Treatment of Persistent Post-Stroke and Vascular Headache
Status: WITHDRAWN
Conditions: Stroke (CVA) or TIA|Headache, Migraine|Botulinum Toxins, Type A|Cerebral Venous Sinus Thrombosis|Carotid Dissection Artery|Vertebral Dissection Artery|Hemorrhagic Stroke|Reversible Cerebral Vasoconstriction Syndrome
Interventions: DRUG: Botox 200 UNT Injection|COMBINATION_PRODUCT: Non Botox based Standard of Care Treatments for Headache/Migraine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 12-Week Study Evaluating the Efficacy, Safety, and Tolerability of Adjunctive Infliximab for Bipolar I/II Depression
Status: COMPLETED
Conditions: Bipolar Depression
Interventions: DRUG: Infliximab|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PEP on a Skin Graft Donor Site Wound
Status: ACTIVE_NOT_RECRUITING
Conditions: Skin Graft
Interventions: BIOLOGICAL: 10% PEP|DRUG: TISSEEL|BIOLOGICAL: 20% PEP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation and Comparison of Two Biomarkers (VOP and SCC) for the Prognosis of the Occurrence of Clinical Cardiovascular Events
Status: COMPLETED
Conditions: Cardiovascular Risk Factor
Interventions: DEVICE: CCS wit CT Scann measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Efficacy, Safety and Immunogenicity of Inactivated COVID 19 Vaccine(TURKOVAC) in Healthy Population of 18 and 64 Years of Age (Both Inclusive):a Randomized, Double-blind, Phase IIb Clinical Trial
Status: UNKNOWN
Conditions: Covid19
Interventions: BIOLOGICAL: Triple dose vaccination by inactivated Covid19 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Innovative Models in the Rehabilitation of the Elderly With Hip Fractures Through Technological Innovation
Status: RECRUITING
Conditions: Hip Fractures|Frail Elderly|Robotic Rehabilitation
Interventions: OTHER: traditional rehabilitation|OTHER: virtual reality games intervention|OTHER: robotic treadmill intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose-ranging Study to Evaluate the Safety and Efficacy of LUSEDRA (Fospropofol Disodium) as an Intravenous Sedative for Diagnostic or Therapeutic Colonoscopy in Adult Special Populations
Status: COMPLETED
Conditions: Sedation
Interventions: DRUG: fospropofol disodium Subgroup 1 Lower Dose|DRUG: fospropofol disodium Subgroup 1 Approved Dose|DRUG: fospropofol disodium Subgroup 2 Lower Dose|DRUG: fospropofol disodium Subgroup 2 Approved Dose|DRUG: fospropofol disodium Subgroup 3 Lower Dose|DRUG: fospropofol disodium Subgroup 3 Approved Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy and GM-CSF in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndromes, Non-Small Cell Lung Cancer, or Mesothelioma
Status: COMPLETED
Conditions: Leukemia|Lung Cancer|Malignant Mesothelioma|Myelodysplastic Syndromes|Primary Peritoneal Cavity Cancer
Interventions: BIOLOGICAL: WT-1 analog peptide vaccine|BIOLOGICAL: incomplete Freund's adjuvant|BIOLOGICAL: sargramostim|GENETIC: polymerase chain reaction|OTHER: flow cytometry|OTHER: immunoenzyme technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determining the Responses and Impact of Rituximab-instigated Cell Depletion on T Cells in People With SLE
Status: WITHDRAWN
Conditions: Lupus Erythematosus, Systemic
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurocognition in Patients With Multiple Brain Metastases Treated With Radiosurgery
Status: RECRUITING
Conditions: Metastatic Malignant Neoplasm in the Brain|Metastatic Malignant Solid Neoplasm
Interventions: PROCEDURE: Cognitive Assessment|RADIATION: Stereotactic Radiosurgery|RADIATION: Stereotactic Body Radiation Therapy|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Alveolar Soft Part Sarcoma|Metastatic Alveolar Soft Part Sarcoma|Locally Advanced Non Small Cell Lung Cancer|Metastatic Non Small Cell Lung Cancer|Locally Advanced Small Cell Lung Cancer|Metastatic Small Cell Lung Cancer|Locally Advanced Hepatocellular Carcinoma|Metastatic Hepatocellular Carcinoma|Locally Advanced Melanoma|Metastatic Melanoma
Interventions: DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Branched-Chain Amino Acid Supplementation and Exercise on Body Composition During Energy Restriction
Status: UNKNOWN
Conditions: Weight Loss|Obesity
Interventions: DIETARY_SUPPLEMENT: Branched-Chain Amino Acid Supplementation|OTHER: Placebo|OTHER: Exercise|OTHER: Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: The Effect of Acute Exercise on Cardiac Autonomic, Cerebrovascular, and Cognitive Function in Spinal Cord Injury
Status: SUSPENDED
Conditions: Spinal Cord Injuries|Cardiovascular Abnormalities|Cerebrovascular Disease; Sequelae|Cognitive Impairment
Interventions: BEHAVIORAL: One bout of moderate-intensity sub-maximal aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigation to Evaluate Safety and Efficacy of the Endodrill Model X Biopsy Instrument
Status: COMPLETED
Conditions: Tumor Sampling
Interventions: DEVICE: Endodrill Model X|DEVICE: Fine-needle aspiration/biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Neuroscience-based Pain Education in Patients With Chronic Neck Pain
Status: RECRUITING
Conditions: Cervical Spine Disease
Interventions: OTHER: Neuroscience-Based Pain Education Combined with Home Exercise Program|OTHER: Myofascial Induction Techniques Combined with Home Exercise Program|OTHER: Home Exercises Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Insulin Glargine for Diabetes Metabolism(DM)Type II Patients Under Enteral Nutrition
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: INSULIN GLARGINE|DRUG: INSULIN GLULISINE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atmeg (Atorvastatin and Omega-3 Combination) and Carotid Atherosclerosis in Patients With Type 2 Diabetes and Combined Dyslipidemia
Status: RECRUITING
Conditions: Dyslipidemias|Atherosclerosis|Diabetes Mellitus, Type 2
Interventions: DRUG: Omega 3-Atorvastatin|DRUG: Omega 3-Atorvastatin|DRUG: Atorvastatin-Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does IV Ondansetron Prevent Pruritus After Intrathecal Morphine in Pediatric Patients?
Status: TERMINATED
Conditions: Pruritus|Nausea/Vomiting
Interventions: DRUG: Ondansetron|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Investigate"Clinically" the Effectiveness of Boswellia Based Intracanal Medication Compared to Calcium Hydroxide Ca(OH)2 and Ledermix on the Levels of Bacteria and Inflammatory Cytokines in Root Canals and Periradicular Tissues of Teeth With Apical Periodontitis
Status: RECRUITING
Conditions: Microbial Colonization
Interventions: DRUG: Calcium hydroxide|DRUG: Leddermix|DRUG: Boswellia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 0804 GCC: MAGE-A3/HPV 16 Vaccine for Squamous Cell Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: BIOLOGICAL: MAGE-A3|BIOLOGICAL: HPV-16 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minocycline for Aneurysmal Subarachnoid Hemorrhage (MASH)
Status: ACTIVE_NOT_RECRUITING
Conditions: Aneurysm, Ruptured|Vasospasm, Intracranial|Delayed Cerebral Ischemia|Blood Brain Barrier Defect
Interventions: DRUG: Minocyclin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of AS101 1% Oral Solution in Patients With Neovascular Age-Related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: AS101 1% oral solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Pharmacokinetics, Safety, Tolerability of Single Dose Lacosamide in Subjects With Renal Impairment Compared to Healthy Subjects
Status: COMPLETED
Conditions: Healthy|Renal Impairment
Interventions: DRUG: Lacosamide tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: The Outreach and Prevention at ALcohol Venues in East Africa Study (OPAL-East Africa- Aim 2) (OPAL-Aim 2)
Status: RECRUITING
Conditions: HIV/AIDS
Interventions: BEHAVIORAL: Healthy Living Intervention (HLI)|BEHAVIORAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Refractory Hemochromatosis Rheumatism by Anakinra: a Preliminary Phase II Study
Status: TERMINATED
Conditions: Refractory Hemochromatosis Rheumatism
Interventions: DRUG: Anakinra
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Everolimus Plus Exemestane in Chinese Postmenopausal Women With Estrogen Receptor Positive, Locally Advanced, Recurrent, or Metastatic Breast Cancer After Recurrence or Progression on Non-steroidal Aromatase Inhibitor
Status: COMPLETED
Conditions: Advanced Breast Cancer
Interventions: DRUG: Everolimus|DRUG: Exemestane|DRUG: Everolimus Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pneumoperitoneum Preconditioning for the Prevention of Renal Function After Laparoscopic Partial Nephrectomy
Status: UNKNOWN
Conditions: Ischemia Reperfusion Injury
Interventions: PROCEDURE: Pneumoperitoneum preconditioning|PROCEDURE: Sham-Pneumoperitoneum preconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of SY-1365 in Adult Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Advanced Solid Tumors|Ovarian Cancer|Breast Cancer
Interventions: DRUG: SY-1365 (Part 1)|DRUG: Carboplatin|DRUG: Fulvestrant|DRUG: SY-1365 (Cohort 2)|DRUG: SY-1365 (Cohort 5)|DRUG: SY-1365 (Part 2 Single Agent)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Of Trabeculectomy Versus The Ex-PRESS Miniature Glaucoma Device In The Same Patient: A Prospective Randomized Study
Status: COMPLETED
Conditions: Glaucoma
Interventions: DEVICE: Ex-PRESS implantation|PROCEDURE: Trabeculectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cohort Study on Plant-based Diets (COPLANT Study)
Status: NOT_YET_RECRUITING
Conditions: Dietary Exposure|Diabetes Mellitus, Type 2|Cardiovascular Diseases|Bone Loss|Sustainability|Exposure|Obesity|Vitamin Deficiency|Mineral Deficiency
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Synbiotic Supplementation in Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Synbiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Assessing the Safety and Immunologic Correlates of Heterologous Prime-Boost With pNGVL4a-Sig/E7(Detox)/HSP70 and TA-HPV in Healthy Donors Followed by Peripheral Blood Collection
Status: ENROLLING_BY_INVITATION
Conditions: HPV 16 Infection|HPV-Related Carcinoma|Recurrence|Metastatic Cancer
Interventions: BIOLOGICAL: pNGVL4a-Sig/E7(detox)/HSP70 plasmid DNA; TA-HPV vaccinia virus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Ig PRx in AECOPD: Pilot Study
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Intravenous immunoglobulin (IVIG)|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Characterization of Metabolic Changes in the Glioma Tumor Tissue Induced by Transient Fasting (ERGO3)
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioma, Mixed
Interventions: OTHER: Fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic
Status: COMPLETED
Conditions: COVID-19|Pregnancy Complications|Mental Health Wellness 1|Anxiety|Depression|Ptsd|Coronavirus
Interventions: OTHER: This is an online survey with no intervention.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CogT pSOPT Intervention Study
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Subjective Cognitive Impairment
Interventions: BEHAVIORAL: pSOPT|BEHAVIORAL: MLA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Clinical Efficacy of Supraglottic Airway Device, Self-pressurized Air-Q Intubating Laryngeal Airway (ILA -SP) in Adult Patients: Comparison With Classic-laryngeal Airway (c-LMA)
Status: COMPLETED
Conditions: Surgery
Interventions: DEVICE: Insertion of C-LMA|DEVICE: Insertion of air-Q according
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Docosahexenoic Acid (DHA) Supplementation and Cardiovascular Disease in Men With High Triglycerides
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DIETARY_SUPPLEMENT: Docosahexenoic acid (DHA)|DIETARY_SUPPLEMENT: Olive oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Azacitidine and Quizartinib for the Treatment of Myelodysplastic Syndrome or Myelodysplastic/Myeloproliferative Neoplasm With FLT3 or CBL Mutations
Status: RECRUITING
Conditions: Chronic Myelomonocytic Leukemia|Myelodysplastic Syndrome|Myeloproliferative Neoplasm|Recurrent Chronic Myelomonocytic Leukemia|Recurrent Myelodysplastic Syndrome|Recurrent Myeloproliferative Neoplasm
Interventions: DRUG: Azacitidine|DRUG: Quizartinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selinexor, Anti-PD-1 Antibody Plus Golidocitinib in R/R NKTCL
Status: NOT_YET_RECRUITING
Conditions: Lymphoma, Extranodal NK-T-Cell
Interventions: DRUG: Selinexor, anti-PD-1 antibody plus Golidocitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Screening for Oculocerebral Lymphoma With the Phenotype of NK Cells in Patients With Uveitis
Status: RECRUITING
Conditions: Uveitis|Lymphoma|NK-Cell Lymphoma
Interventions: BIOLOGICAL: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Human Cell Line-derived Recombinant Factor VIII (Human-cl-rhFVIII) in Previously Untreated Patients
Status: COMPLETED
Conditions: Severe Hemophilia A
Interventions: BIOLOGICAL: Human cl rhFVIII
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Atherosclerosis and Heart Disease in Patients With Systemic Lupus Erythematosis (SLE)
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus|Lupus
Interventions: DRUG: pravastatin|DRUG: aspirin|DRUG: ramipril|DRUG: Vitamins: B6, B12, and folate|BEHAVIORAL: heart health educational program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: PREventative Study Against URate-Lowering Drug-Induced Gout Exacerbations (PRE-SURGE 2)
Status: COMPLETED
Conditions: Gout
Interventions: DRUG: Placebo|DRUG: Rilonacept|DRUG: Rilonacept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of 3,4-Methylenedioxymethamphetamine-assisted Psychotherapy in People With Posttraumatic Stress Disorder
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: 3,4-methylenedioxymethamphetamine (125 mg)|DRUG: 3,4-methyelendioxymethamphetamine (25 mg)|BEHAVIORAL: Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Potato Resistant Starch Intake on Insulin Sensitivity, Related Metabolic Markers and Satiety
Status: COMPLETED
Conditions: Insulin Sensitivity|Lipid Metabolism|Resistant Starch|Potato
Interventions: OTHER: Potato (Resistant Starch)|OTHER: CHO-matched (Low-fiber, RS-free)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of Fruquintinib+FOLFIRI in RAS-mutated Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Combination: Fruquintinib + FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myofascial Pain Patients' Response to the Administration of Low Doses of Amitriptyline and Citalopram Compared With the Use of Bite Splint
Status: UNKNOWN
Conditions: Muscle Type Temporomandibular Disorders|Myofascial Pain of the Masticatory Muscles
Interventions: DRUG: Citalopram 10 MG|DRUG: Amitriptyline|DEVICE: Bite Splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Dosing of Dorsal Root Ganglion Stimulation as an Alternate Paradigm to Continuous Low-Frequency Therapy
Status: RECRUITING
Conditions: CRPS (Complex Regional Pain Syndromes)|Radiculopathy|Peripheral Neuropathy
Interventions: DEVICE: DRG stimulation 20 Hz 30/90|DEVICE: DRG stimulation 5 Hz 30/90
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Internet CBT for Antenatal Depression
Status: RECRUITING
Conditions: Antenatal Depression
Interventions: BEHAVIORAL: Therapist Guided Internet-CBT for antenatal depression|BEHAVIORAL: Therapist Guided Internet-CBT for antenatal depression and perinatal extra support.|BEHAVIORAL: Diagnostic assessment by telephone, video or face-to face - Allocation by chance|BEHAVIORAL: Diagnostic assessment by telephone, video or face-to face - Allocation by choice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability, and Pharmacokinetics Study of Onartuzumab as Single Agent or in Combination With Sorafenib in Participants With Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Onartuzumab|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety and Tolerability of Canakinumab Prefilled Syringes in Frequently Flaring Acute Gouty Arthritis Patients
Status: COMPLETED
Conditions: Acute Gouty Arthritis
Interventions: DRUG: Canakinumab 150mg in prefilled syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Omega-3/Low Omega-6 Treatment Diet for Aspirin-exacerbated Respiratory Disease (AERD)
Status: COMPLETED
Conditions: ASA Triad|Asthma, Nasal Polyps, And Aspirin Intolerance
Interventions: BEHAVIORAL: Restricting daily intake of omega-6 fatty acids to less than 4 grams and increasing omega-3 fatty acids to 3 grams
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-human Study to Assess Safety and Tolerability of a Single Subcutaneous Dose of SAR441255 in Lean to Overweight Subjects
Status: COMPLETED
Conditions: Overweight|Healthy Subjects
Interventions: DRUG: SAR441255|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Simpliciti IDE Trial; Replacing the Humeral Head in Total Shoulder Arthroplasty
Status: COMPLETED
Conditions: Primary Generalized (Osteo)Arthritis|Post-traumatic Arthrosis of Other Joints, Upper Arm
Interventions: DEVICE: Simpliciti™ Shoulder System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Lung Cancer Chemoprevention With Sulforaphane in Former Smokers
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DIETARY_SUPPLEMENT: Sulforaphane|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Trinity Evolution in Patients Undergoing Foot and Ankle Fusion
Status: COMPLETED
Conditions: Tibiotalar Arthrodesis|Subtalar Arthrodesis|Calcaneocuboid Arthrodesis|Talonavicular Arthrodesis|Double Arthrodesis (i.e. Calcaneocuboid and Talonavicular)|Triple Arthrodesis (i.e. Subtalar, Calcaneocuboid, and Talonavicular)
Interventions: BIOLOGICAL: Trinity Evolution
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Telephone Delivered Behavioral Skills Intervention for Blacks With T2DM
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Diabetes Mellitus, Adult-Onset|Diabetes Mellitus, Non-Insulin-Dependent|Diabetes Mellitus, Noninsulin Dependent|Diabetes Mellitus, Type II
Interventions: BEHAVIORAL: Diabetes Knowledge/Information|BEHAVIORAL: Motivation/Behavioral Skills|BEHAVIORAL: Combined Intervention|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Monosodium Glutamate on Energy Balance and Eating Behavior
Status: COMPLETED
Conditions: Obesity|Weight Gain|Food Preferences
Interventions: OTHER: Broth|OTHER: Broth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neoadjuvant Toripalimab in Combination With Carboplatin and Nab-paclitaxel in Untreated Salivary Gland Malignant Neoplasms
Status: NOT_YET_RECRUITING
Conditions: Salivary Gland Malignant Neoplasms|Salivary Gland Tumors
Interventions: DRUG: Toripalimab , Carboplatin, Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Gevokizumab to Treat Non-infectious Uveitis Controlled With Systemic Treatment
Status: TERMINATED
Conditions: Uveitis
Interventions: DRUG: Placebo|DRUG: Dose 1 gevokizumab|DRUG: Dose 2 gevokizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SI-6603 (Condoliase) Study for Lumbar Disc Herniation (Discovery 6603 Study)
Status: COMPLETED
Conditions: Lumbar Disc Herniation
Interventions: DRUG: SI-6603|DRUG: Sham injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ZnAg Liquid Solution to Treat COVID-19 Symptomatic Participants
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: CNM-ZnAg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Yoga on Sexual Function in Primiparous Pregnants
Status: UNKNOWN
Conditions: Pregnancy Related|Sexual Dysfunction|Exercise
Interventions: OTHER: Yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Atezolizumab in Advanced Solid Tumors
Status: COMPLETED
Conditions: Tumors
Interventions: DRUG: Atezolizumab (MPDL3280A), an engineered anti-programmed death-ligand 1 (PD-L1) antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intravenous Magnesium During Robot Assisted Prostatectomy
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: Magnesium Sulfate|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Novel Therapies for Metabolic Complications of Lipodystrophies
Status: COMPLETED
Conditions: Insulin Resistance|Hypertriglyceridemia|Diabetes|Hepatic Steatosis
Interventions: OTHER: low-fat diet ( Still recruiting )|OTHER: Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of Smoking on Non-surgical Periodontal Therapy in Generalized Aggressive Periodontitis
Status: COMPLETED
Conditions: Generalized Aggressive Periodontitis|Smoking
Interventions: PROCEDURE: Non-surgical periodontal therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Endoleaks Using Autologous Platelet Gel on Unruptured Abdominal Aortic Aneurysms
Status: TERMINATED
Conditions: Abdominal Aortic Aneurysms
Interventions: PROCEDURE: PRP + autologous thrombin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prospective Non-Interventional Study Comparing Osimertinib +/- Chemotherapy for EGFR-Mutated NSCLC Patients
Status: NOT_YET_RECRUITING
Conditions: Non Small Cell Lung Cancer|Epidermal Growth Factor Receptor Gene Mutation|Stage III Lung Cancer|Stage IV Lung Cancer
Interventions: DRUG: Osimertinib|DRUG: Osimertinib + Chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Multidisciplinary Approach to Improve the Health of Older Adults With Blood Cancers After Stem Cell Transplantation
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm
Interventions: OTHER: Health Promotion|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Polypill in Acute Coronary Syndrome
Status: RECRUITING
Conditions: Acute Coronary Syndrome|Lipid Disorder|Coronary Artery Disease
Interventions: DRUG: Polypill|DRUG: Usual Care (individual medications prescribed by primary cardiologist)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Ex-PRESS Implantation Combined With Phacoemulsification in Primary Angle-closure Glaucoma
Status: UNKNOWN
Conditions: Glaucoma, Angle-Closure
Interventions: PROCEDURE: Ex-PRESS and phacoemulsification
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LCCC 1128: Open Label Phase II Trial of the BRAF Inhibitor (Dabrafenib) and the MEK Inhibitor (Trametinib) in Unresectable Stage III and Stage IV BRAF Mutant Melanoma; Correlation of Resistance With the Kinome and Functional Mutations
Status: COMPLETED
Conditions: Stage III Melanoma|Stage IV Melanoma|Unresectable Melanoma|BRAF Mutant Melanoma
Interventions: DRUG: BRAF inhibitor dabrafenib and MEK inhibitor trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Safety of IMP321 (Eftilagimod Alpha) for Advanced Stage Solid Tumors
Status: RECRUITING
Conditions: Solid Tumors|Peritoneal Carcinomatosis
Interventions: DRUG: IMP321|DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A New Digital Communication Tool Between Dentist and Orthodontist to Improve Dental Prevention
Status: RECRUITING
Conditions: Reduction in DMFT Index and Plaque Index in Patients at the Treatment Completion, an Average of 4 Years|DMFT Index, ICDAS Score, Dental Plaque Index, Communication, Prevention, Dentist, Orthodontist
Interventions: OTHER: There is no intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Open-Label, Multi-Centre, Randomised, Switch Study to Evaluate the Virological Efficacy Over 96 Weeks Of 2-Drug Therapy With DTG/RPV FDC in Antiretroviral Treatment-Experienced HIV-1 Infected Subjects Virologically Suppressed With NNRTIs Resistance Mutation K103N
Status: COMPLETED
Conditions: HIV-1-infection
Interventions: DRUG: Dolutegravir & Rilpivirine 2 drug fixed dose combined therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Extracorporeal Adsorption of Plasma Neutrophil Extracellular Traps (NET) in Sepsis
Status: COMPLETED
Conditions: Sepsis|Sepsis-associated AKI
Interventions: DEVICE: NucleoCapture device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atacicept Phase 2/3 in Generalized Systemic Lupus Erythematosus (APRIL-SLE)
Status: COMPLETED
Conditions: Lupus Erythematosus, Systemic
Interventions: DRUG: Atacicept 75 mg|DRUG: Atacicept 150 mg|OTHER: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Age-Related Hearing Loss Investigation (EARHLI)
Status: RECRUITING
Conditions: Alzheimer Disease|Hearing Loss|Cognitive Impairment
Interventions: DEVICE: Hearing Intervention|BEHAVIORAL: Health Education Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT