pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Preoperative Treatment of Malleolar Fractures
Status: UNKNOWN
Conditions: Ankle Fractures|Intermittent Pneumatic Compression|Comparative Study|Preoperative Care
Interventions: DEVICE: Flowtron ACS800|OTHER: Bandage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study to Evaluate the Efficacy and Safety of AK120 in Patients With Moderate to Severe Atopic Dermatitis
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: AK120
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Oral Versus Parenteral Antimicrobial Therapy
Status: ENROLLING_BY_INVITATION
Conditions: Endovascular Infection|Bone and Joint Infection|Skin and Soft Tissue Infection|Pulmonary Infection|Gastrointestinal Infection|Genitourinary Infection
Interventions: DRUG: Amoxicillin, amoxicillin-clavulanate, cefadroxil, cefpodoxime, cefalexin, ciprofloxacin, delafloxacin, doxycycline, levofloxacin, linezolid|DRUG: Ampicillin, ampicillin-sulbactam, cefazolin, cefepime, ceftaroline, ceftazidime, ceftazidime-avibactam, dalbavancin, daptomycin, ertapenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adult Subjects With Elevated Low-Density Lipoprotein-Cholesterol to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects
Status: RECRUITING
Conditions: To Reduce the LDL-C Level in Hypercholesteremia Adult Patients|Combination for Subgroup High LDL-c Patients With Other Comorbidities
Interventions: DRUG: RN0191 INJECTION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pelvic Radiation Therapy or Vaginal Implant Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With High-Risk Stage I or Stage II Endometrial Cancer
Status: UNKNOWN
Conditions: Endometrial Clear Cell Adenocarcinoma|Endometrial Serous Adenocarcinoma|Fatigue|Neurotoxicity Syndrome|Obesity|Stage I Uterine Corpus Cancer AJCC v7|Stage II Uterine Corpus Cancer AJCC v7
Interventions: RADIATION: 3-Dimensional Conformal Radiation Therapy|DRUG: Carboplatin|RADIATION: Intensity-Modulated Radiation Therapy|RADIATION: Internal Radiation Therapy|OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multidisciplinary Team Care in Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Multidisciplinary Communication
Interventions: OTHER: Visit to a multidisciplinary clinic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Performance Assessment of a First Four Arms on Demand Open Robotic Solution for Assisted PN, RN and RP
Status: COMPLETED
Conditions: Nephrectomy|Prostatectomy
Interventions: DEVICE: Robot assisted laparoscopic Radical/simple nephrectomy (RN), Partial nephrectomy (PN) or Radical Prostatectomy (RP).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Darsilide Combined With AI, Trastuzumab and Patuzumab in the Neoadjuvant Treatment of HR+/HER2+ Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|HER2-positive Breast Cancer
Interventions: DRUG: Dalcilib+letrozole+HP treatment group
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Multicenter All Comers Study of Phasix Mesh for Ventral or Incisional Hernia Repair
Status: COMPLETED
Conditions: Ventral Hernia|Incisional Hernia
Interventions: DEVICE: Resorbable Mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Vitamin A Treatment for Children With Sepsis
Status: UNKNOWN
Conditions: Vitamin A Deficiency|Pediatric|Sepsis
Interventions: DRUG: Vitamin A|DRUG: Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Clonidine for Sleep Disturbances in Children With Autism Spectrum Disorder
Status: WITHDRAWN
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Clonidine|DRUG: Placebo (for clonidine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Immunogenicity and Safety of 3 Lots of NVX-CoV2373 in Adults
Status: COMPLETED
Conditions: COVID-19|SARS-CoV-2 Infection
Interventions: DRUG: NVX-Cov2373
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: POLY-unsaturated Fatty Acids in the Preservation of Dietary Effects on Hepatosteatosis and Energy Metabolism in Type 2 Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes|NAFLD|Obesity|Dyslipidemia|Hypertension|Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: diet with/without supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Managing Dentine Hypersensitivity With Silver Diamine Fluoride on Older Adults
Status: RECRUITING
Conditions: Dentine Hypersensitivity
Interventions: DEVICE: SDF|DEVICE: KNO3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patterns of Prescribing and Monitoring of Palbociclib
Status: COMPLETED
Conditions: Metastatic Breast Cancer|Advanced Breast Cancer|Estrogen Receptor-positive Breast Cancer|Human Epidermal Growth Factor 2 Negative Carcinoma of Breast
Interventions: DRUG: Palbociclib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Velcade (Bortezomib), Adriamycin Dexamethasone (PAD) or Vincristine Adriamycin Dexamethasone in Second Line Treatment of Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: adriamycin|DRUG: bortezomib|DRUG: dexamethasone|DRUG: vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Software Interventions for Improving Hand Washing and Sanitation in Rural Tanzania: an Impact Evaluation
Status: COMPLETED
Conditions: Diarrhea
Interventions: OTHER: Hardware|BEHAVIORAL: CLTS|BEHAVIORAL: PHAST|BEHAVIORAL: RANAS|BEHAVIORAL: mini-RANAS|OTHER: Placebo poster
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pen Torch Transillumination: Shedding Light on Difficult Venepuncture
Status: COMPLETED
Conditions: Disorder of Vein
Interventions: DEVICE: Veinlite|DEVICE: Pen-torch Transillumination|PROCEDURE: Conventional Venepuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Complementary Effect of Ear Acupressure on Older Patients With Chronic Insomnia
Status: COMPLETED
Conditions: Insomnia
Interventions: OTHER: ear acupressure|OTHER: sham ear acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cyclical Neuroactive Steroid Changes, Arousal, and Proximal Suicide Risk: An Experimental Approach
Status: ACTIVE_NOT_RECRUITING
Conditions: Suicidal Ideation
Interventions: DRUG: Estradiol Transdermal Patch 0.1 mg/24 hrs|DRUG: Oral Micronized Progesterone 200mg|DRUG: Inactive Clear Patch|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trilaciclib, a CDK 4/6 Inhibitor, in Patients Receiving FOLFOXIRI/Bevacizumab for Metastatic Colorectal Cancer (mCRC):
Status: TERMINATED
Conditions: Colorectal Cancer Metastatic|Myelosuppression-Adult|Chemotherapeutic Toxicity
Interventions: DRUG: Trilaciclib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Cobitolimod in Participants With Moderate to Severe Active Left-Sided Ulcerative Colitis
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: DRUG: Cobitolimod 250 mg|DRUG: Cobitolimod 500 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement
Status: RECRUITING
Conditions: Malignant Pleural Neoplasm
Interventions: DRUG: Lidocaine|DRUG: Liposomal Bupivacaine|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Use of Exhaled Carbon Dioxyde for Monitoring the Native Cardiac Function During Mechanical Circulatory Support With Venoarterial By-pass in Intensive Care Unit
Status: COMPLETED
Conditions: Residual Cardiac Output During PVA-ECMO
Interventions: DEVICE: PetCO2 monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Topical Nitroglycerin To Prevent Radial Artery Occlusion After Transradial Access: NTP-RAO Trial
Status: UNKNOWN
Conditions: Total Atherosclerotic Occlusion of Radial Artery
Interventions: DRUG: Nitroglycerin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Follow-up Strategies for Improved Postoperative Recovery After Benign Hysterectomy
Status: COMPLETED
Conditions: Hysterectomy|Genital Diseases, Female|Pain
Interventions: BEHAVIORAL: Follow-up strategy|BEHAVIORAL: No contact after discharge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Outpatient Induction of Labour Using Intracervical Foley Catheter
Status: NOT_YET_RECRUITING
Conditions: Pregnancy Related|Induction of Labor Affected Fetus / Newborn
Interventions: DEVICE: Foley catheter|DRUG: Intravaginal prostaglandin E2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-Myalgia
Status: UNKNOWN
Conditions: Taxane|Drug-related Side Effects and Adverse Reactions|Pain|Breast Cancer
Interventions: DRUG: Pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Pharmacodynamics, and Safety of Alogliptin in Children, Adolescents and Adults With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Alogliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Use of Negative Pressure Wound Therapy in Morbidly Obese Women After Cesarean Delivery
Status: TERMINATED
Conditions: Obesity, Morbid|Wound Infection|Wound Complication
Interventions: DEVICE: Negative pressure wound therapy (PREVENA Incision Management Therapy System)|DEVICE: Standard dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluate Safety and the Oncolitic Adenovirus VCN-01 Activity in Patients With Refractory Retinoblastoma
Status: COMPLETED
Conditions: Retinoblastoma, Recurrent
Interventions: GENETIC: VCN-01
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Transdiagnostic Internet-based Treatment for Emotional Disorders
Status: COMPLETED
Conditions: Anxiety|Depression
Interventions: BEHAVIORAL: Emotion Regulation Protocol|DRUG: Treatment as Usual (Pharmacological Treatment)|BEHAVIORAL: Treatment as Usual (Psychological Treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of Quadrivalent Influenza Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: GC FLU Quadrivalent|BIOLOGICAL: Fluarix Tetra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Exposure, D-Cycloserine Enhancement, and Genetic Modulators in Panic Disorder
Status: COMPLETED
Conditions: Panic Disorder
Interventions: DRUG: d-cycloserine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hypofractionated Radiochemotherapy
Status: NOT_YET_RECRUITING
Conditions: Uterine Cervix Cancer
Interventions: DRUG: Cisplatin|RADIATION: intensity modulated radiation therapy (IMRT)|RADIATION: high-dose-rate (HDR) brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Infusion of Palonosetron for Preventing of Postoperative Nausea and Vomiting
Status: UNKNOWN
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: continuous infusion of palonosetron added to prophylactic single injection of palonosetron|DRUG: continuous infusion of normal saline added to prophylactic single injection of palonosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of QL1706 in Combination With Bevacizumab and/or Chemotherapy as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: QL1706|DRUG: Bevacizumab|DRUG: Oxaliplatin injection|DRUG: Capecitabine|DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Medication With or Without Psychotherapy for Complicated Grief
Status: COMPLETED
Conditions: Complicated Grief|Bereavement
Interventions: DRUG: Citalopram|BEHAVIORAL: Complicated Grief Treatment|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Maralixibat in Pruritus Associated With General Cholestatic Liver Disease (EXPAND)
Status: NOT_YET_RECRUITING
Conditions: Cholestatic Liver Disease (Except ALGS, PFIC, PBC and PSC)
Interventions: DRUG: Maralixibat|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Combining Erector Spinea Block With Non Opioid Infusions as Opioid Free Anesthesia in Spine Surgeries.
Status: NOT_YET_RECRUITING
Conditions: Opioid Use|Spine Fusion
Interventions: DRUG: fentanyl infusion after general anesthesia and erector spinea block|DRUG: lidocaine 2% and dextometometidine infusion after general anesthesia and erector spinea block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Drug Interaction Study to Assess the Effect of LY2603618 on the Metabolic Pathway of Desipramine
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: LY2603618|DRUG: Desipramine|DRUG: Pemetrexed|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pnemoperitoneum on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Surgery According to Anesthesia Agents: Propofol Based Total Intravenous Anesthesia vs Desflurane Anesthesia
Status: WITHDRAWN
Conditions: Optic Nerve Sheath
Interventions: DRUG: Propofol|DRUG: Desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Cardioneuroablation vs Pulmonary Vein Isolation in Treatment of Paroxysmal Atrial Fibrillation
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation Paroxysmal
Interventions: PROCEDURE: Cardioneuroablation of right anterior ganglionated plexus|PROCEDURE: Pulmonary vein isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Iclepertin Effect on Cognition and Functional Capacity in Schizophrenia (CONNEX-1)
Status: ACTIVE_NOT_RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: Iclepertin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Delay and Antibiotics on Perforation Rate While Waiting Appendectomy
Status: COMPLETED
Conditions: Appendicitis
Interventions: DRUG: Antibiotics, cefuroxime and metronidazole|DRUG: No antibiotics|OTHER: urgent schedule|OTHER: less urgent schedule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Lavender and Chamomile Essential Oils Inhalation in Management of Dental Anxiety and Pain in Children Undergoing Local Anesthesia Administration and Primary Tooth Extraction
Status: NOT_YET_RECRUITING
Conditions: Anxiety, Dental
Interventions: DRUG: Lavender and Chamomile Essential Oils
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Plasma-air-filtration on the Incidence of Surgical Site Infections in Orthopaedic Surgery
Status: COMPLETED
Conditions: Orthopaedic Surgery (30 Minutes or Longer)
Interventions: DEVICE: Novaerus NV800 on|DEVICE: Novaerus NV800 off|DEVICE: Novaerus NV800 on or off
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: rTMS Over the Dorsolateral Prefrontal Cortex for the Treatment of Impulse Control Disorders in Parkinson's Disease
Status: RECRUITING
Conditions: Impulse Control Disorder|Parkinson Disease
Interventions: DEVICE: rTMS Active|DEVICE: rTMS Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Protective Efficacy of a Vaccine Derived From the Synthetic CS Protein of Plasmodium Vivax
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: Vaccine PvCS N+C+R|BIOLOGICAL: Vaccine PvCS N+C|BIOLOGICAL: SSN Montanide ISA-51
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Delta-9-Tetrahydrocannabinol on the Prevention of Chronic Pain in Patients With Acute CRPS (ETIC-Study)
Status: UNKNOWN
Conditions: Complex Regional Pain Syndromes|CRPS
Interventions: DRUG: Delta9-Tetrahydrocannabinol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Study of F-652 in Subjects With Corona Virus Disease 2019 (COVID-19) Pneumonia
Status: WITHDRAWN
Conditions: COVID-19 Pneumonia
Interventions: BIOLOGICAL: F-652|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Infection Control, Practice Efficiency, and Health Economics of Sheathed Versus Standard Cystoscopy
Status: COMPLETED
Conditions: Bacteriuria
Interventions: DEVICE: EndoSheath CST-5000 Scope|DEVICE: Olympus Visera Elite OTV-S190 Scope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Median Effective Dose of Remimazolam for Duodenoscopy Insertion During ERCP With Alfentanil 10µg/kg
Status: UNKNOWN
Conditions: Anesthesia
Interventions: DRUG: Remimazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Graftless Lateral Maxillary Sinus Lift Balloon by Different Antrostomy Sizes With Simultaneous Implant Placement
Status: UNKNOWN
Conditions: Atrophy of Edentulous Maxillary Alveolar Ridge
Interventions: PROCEDURE: maxillary sinus lift
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Combining Animal-assisted Intervention and Placebo-induced Analgesia
Status: COMPLETED
Conditions: Pain|Therapeutic Alliance|Placebo
Interventions: OTHER: Animal-assisted placebo condition|OTHER: Placebo condition|OTHER: Dog only condition|OTHER: Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Accuracy Of Skin Prick Test Using In-house Wheat Extract For The Diagnosis Of IgE-mediated Wheat Allergy: A Pilot Study
Status: COMPLETED
Conditions: Wheat Allergy
Interventions: OTHER: Commercial extract and in-house wheat extract
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluate the Effect of Ethinyl Estradiol/Norgestimate on the Pharmacokinetics of Lomitapide in Healthy Female Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: lomitapide|DRUG: EE/norgestimate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Analyze the Effects of Exparel for Post-Surgery Pain Control in Patients Undergoing Penile Prosthesis Placement
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Randomization of two local anesthetics.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of a Morphomic-Based to the Standard-of-Care-Based Cefazolin Dose for Antimicrobial Prophylaxis
Status: RECRUITING
Conditions: Surgical Prophylaxis
Interventions: DRUG: Cefazolin for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Transverse Preputial Island Flap Versus Double Faced Preputial Flap for Repair of Penoscrotal Hypospadias With Chordee
Status: COMPLETED
Conditions: Hypospadias, Penoscrotal|Chordee
Interventions: PROCEDURE: Transverse preputial island flap (Duckett's technique)|PROCEDURE: Double-faced preputial flap (DFPF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Post-Procedure Administration of Celecoxib Following Shoulder Surgery
Status: UNKNOWN
Conditions: Reverse or Primary Total Shoulder|Rotator Cuff- Full Thickness- Repair
Interventions: DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)
Status: COMPLETED
Conditions: Opioid Use|Pain, Postoperative
Interventions: DRUG: Methadone|DRUG: Fentanyl|DRUG: Hydromorphone|DRUG: Morphine|DRUG: Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Drug Induced Ototoxicity in Peritoneal Dialysis Patients by N-Acetylcysteine
Status: COMPLETED
Conditions: Drug-induced Ototoxicity in Peritoneal Dialysis Patients
Interventions: DRUG: N-acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Use of Zolpidem in Parkinson's Disease
Status: WITHDRAWN
Conditions: Parkinson's Disease
Interventions: DRUG: Levodopa|DRUG: Zolpidem first dose|DRUG: Zolpidem second dose|DRUG: sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Five-day 20-minute 10-Hz tACS in Patients With a Disorder of Consciousness
Status: NOT_YET_RECRUITING
Conditions: Brain Injury Traumatic Severe|Disorder of Consciousness|Brain Injuries
Interventions: DEVICE: Active Transcranial alternative current stimulation|DEVICE: SHAM Transcranial alternative current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomised, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Sevelamer Carbonate Tablets Dosed Three Times a Day in Hyperphosphataemic Chronic Kidney Disease Patients Not on Dialysis
Status: TERMINATED
Conditions: Chronic Kidney Disease|Hyperphosphatemia
Interventions: DRUG: Sevelamer carbonate|DRUG: Placebo for sevelamer carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial to Explore Niraparib and Anlotinib Maintenance Retreatment in Platinum-Sensitive Recurrent Ovarian Cancer Patients Previously Treated With PARPi
Status: UNKNOWN
Conditions: Epithelial Ovarian Cancer
Interventions: DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adherence and Coagulation Assays in Dabigatran-treated Patients With Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation|Medication Adherence|Blood Coagulation Tests|Anticoagulants; Circulating, Hemorrhagic Disorder|Drug Effect|Drug Use|Drug Toxicity|Drug Intolerance|Blood Clot|Blood Coagulation Disorder|Laboratory Problem|Bleeding|Thrombosis
Interventions: OTHER: Bloodtest|OTHER: Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetics of BIA 9-1067 and Its Metabolites in Healthy Male Elderly Subjects and in Healthy Male Young Subjects
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: BIA 9-1067
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optic Coherence Tomography in Patients With Amyotrophic Lateral Sclerosis
Status: UNKNOWN
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DIAGNOSTIC_TEST: Optic coherence tomography|DIAGNOSTIC_TEST: Pulmonary function test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of the Management of Post-prandial Hyperglycemia by Multiple Bolus Calculators
Status: COMPLETED
Conditions: Diabetes Mellitus Type 1
Interventions: DEVICE: Accu-Chek Combo Kit mg DE/de
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Value of IVL Compared To OPN Non-Compliant Balloons for Treatment of RefractorY Coronary Lesions (VICTORY) Trial
Status: RECRUITING
Conditions: Coronary Disease|Coronary Artery Disease|Calcific Coronary Arteriosclerosis|Stent Restenosis|Coronary Artery Calcification
Interventions: DEVICE: OPN™ NCB Super High Pressure PCI Balloon|DEVICE: Shockwave™ C2 IVL Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of EBUS-TBNA Versus Conventional TBNA in Diagnosis of Sarcoidosis
Status: COMPLETED
Conditions: Sarcoidosis
Interventions: OTHER: EBUS-TBNA|OTHER: Conventional TBNA|OTHER: Endobronchial and transbronchial biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Stability of Implants With Different Surface Treatment: Randomized Clinical Trial
Status: UNKNOWN
Conditions: Edentulous Jaws Partially
Interventions: DEVICE: RFA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: EARTH 413: A Study of Aricept in Hispanic Patients With Mild to Moderate Alzheimer's Disease (AD)
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Aricept
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Milnacipran in Chronic Neuropathic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: Milnacipran|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Real-life Assessment of Abilify Maintena + Rexult in Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia and Related Disorders|Anxiety Depression
Interventions: DRUG: ARIPiprazole Injection [Abilify]|DRUG: Brexpiprazole
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Polycystic Ovary Syndrome and Liraglutide as Add-on Therapy on Metformin
Status: COMPLETED
Conditions: PCOS|Obesity
Interventions: DRUG: metformin|DRUG: liraglutide|DRUG: metformin and liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Etoricoxib in Participants With Osteoarthritis Not Responding to Analgesic Drugs (MK-0663-142)
Status: WITHDRAWN
Conditions: Osteoarthritis
Interventions: DRUG: Etoricoxib|DRUG: Placebo for etoricoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Celecoxib in Preventing Colorectal Cancer in Young Patients With a Genetic Predisposition for Familial Adenomatous Polyposis
Status: COMPLETED
Conditions: Colorectal Cancer|Precancerous Condition
Interventions: DRUG: celecoxib|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Evaluating Optimal Timing of Endocrine Therapy and Radiation Therapy in Early-stage Breast Cancer (REaCT-RETT)
Status: COMPLETED
Conditions: Early-stage Breast Cancer
Interventions: COMBINATION_PRODUCT: Endocrine Therapy and Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Femtosecond Laser Versus Microkeratome in Creating Corneal Flaps in LASIK
Status: UNKNOWN
Conditions: Femtosecond Laser in Comparison to Moria Microkeratome in Creating Corneal Flaps
Interventions: DEVICE: anterior segment Ocular Coherence Tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase II Study of PF-03446962 in Patients With Advanced Malignant Pleural Mesothelioma
Status: COMPLETED
Conditions: Malignant Pleural Mesothelioma
Interventions: DRUG: PF-03446962
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Lactobacillus Plantarum 299v in Treatment of Cancer Patients Who Received Home Enteral Nutrition
Status: COMPLETED
Conditions: Cancer
Interventions: DIETARY_SUPPLEMENT: Lactobacillus plantarum 299v|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BL-8040 Addition to Consolidation Therapy in AML Patients
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Cytarabine|DRUG: BL-8040|DRUG: Placebo (for BL-8040)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Primary Percutaneous Pericardiotomy for Malignant Pericardial Effusion (PMAP)
Status: UNKNOWN
Conditions: Pericardial Effusion Malignant
Interventions: DEVICE: Percutaneous Balloon Pericardiotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Treatment With Macrobid Reduce Urinary Tract Infections in Patients Receiving a Sub-Urethral Sling for Incontinence
Status: COMPLETED
Conditions: Stress Incontinence
Interventions: DRUG: Nitrofurantoin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Eugenol-based Product to Improve the Quality of Toothbrushing and Relieving Gum Discomfort Areas
Status: COMPLETED
Conditions: Plaque, Dental
Interventions: DRUG: fluoride toothpaste containing 1450 ppm of MFP in a PCC base and eugenol gum product|DRUG: fluoride toothpaste containing 1450 ppm of MFP in a PCC base
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacodynamic/Pharmacokinetic Study to Determine the Onset of Analgesic Effect and Plasma Levels of Tramadol in Patients With Acute Low Back Pain Receiving a Single 200 mg Dose of Tramadol Contramid® Once-a-Day
Status: COMPLETED
Conditions: Acute Low Back Pain
Interventions: DRUG: Tramadol Contramid® OAD 200mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Traditional Greek Meals on Glycemic Responses
Status: COMPLETED
Conditions: Potential Abnormality of Glucose Tolerance|Appetitive Behavior
Interventions: OTHER: Glucose as reference food|OTHER: Lentils and lupins mixed meal|OTHER: Trahanas with tomato sauce mixed meal|OTHER: Halva with currants mixed meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Acupressure for Aromatase Inhibitor-Associated Musculoskeletal Symptoms in Patients With Breast Cancer
Status: RECRUITING
Conditions: Postmenopausal|Breast Cancer
Interventions: OTHER: Acupressure|OTHER: Acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mulligan and Maitland Techniques in Post PRP Knee Osteoarthritis
Status: NOT_YET_RECRUITING
Conditions: Knee Osteoarthritis
Interventions: OTHER: Mulligan(MWM) MobilizationTechnique|OTHER: Maitland Mobilization technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Extension Trial to Investigate Long-Term Treatment With Transdermal Rotigotine in Idiopathic Restless Legs Syndrome
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DRUG: Rotigotine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Left Bundle Branch Area Pacing for Cardiac Resynchronization Therapy: A Randomized Study
Status: RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: PROCEDURE: Left Bundle Branch Area Pacing (LBBAP)|PROCEDURE: Biventricular pacing (BiV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of High FIO2 on Post-ERCP Pancreatitis.
Status: COMPLETED
Conditions: Post-ERCP Pancreatitis
Interventions: PROCEDURE: Use of different concentrations of oxygen during ERCP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Study of SPG302 in Adult Participants With Mild-to-Moderate Alzheimer's Disease (AD)
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: SPG302|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of EVO100 for Prevention of Urogenital Chlamydia Trachomatis and Neisseria Gonorrhoeae Infection
Status: COMPLETED
Conditions: Sexually Transmitted Diseases|Gonorrhea|Chlamydia
Interventions: DRUG: EVO100|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 1-2 Study of Low Dose ASTX727 (ASTX727 LD) in Lower Risk MDS
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: ASTX727 LD|DRUG: ASTX727 SD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1-2 Evaluation of OT-730 Eye Drops in Reducing the Intraocular Pressure in Patients With Ocular Hypertension or Open-Angle Glaucoma
Status: COMPLETED
Conditions: Glaucoma, Open-Angle|Ocular Hypertension
Interventions: DRUG: OT-730 ophthalmic solution|DRUG: timolol maleate ophthalmic solution|DRUG: OT-730 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fluvoxamine Maleate in the Treatment of Obsessive-Compulsive Disorder: A Post-marketing Clinical Study in Children and Adolescents
Status: TERMINATED
Conditions: Obsessive Compulsive Disorder
Interventions: DRUG: Fluvoxamine maleate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AMD3100 With Busulfan, Fludarabine and Thymoglobulin for Allogeneic Stem Cell Transplant for AML and MDS
Status: WITHDRAWN
Conditions: Acute Myelogenous Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: AMD3100|PROCEDURE: Allogeneic Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Response to Isometric BFR Exercise
Status: NOT_YET_RECRUITING
Conditions: Blood Pressure
Interventions: BEHAVIORAL: Isometric handgrip exercise|BEHAVIORAL: Isometric handgrip exercise with a narrow-elastic band|BEHAVIORAL: Isometric handgrip exercise with a wide-rigid cuff
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Real-Time Continuous Glucose Monitoring (RT-CGM) in Patients With Type 1 Diabetes at High Risk for Low Glucose Values Using Multiple Daily Injections (MDI) in Germany (HYPODE-STUDY)
Status: COMPLETED
Conditions: Diabetes
Interventions: DEVICE: Continuous Glucose Monitoring System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose:
Clinical trial: Effect of Dexmedetomidine on Plasmatic Cortisol Response in Transsphenoidal Surgery
Status: UNKNOWN
Conditions: Pituitary Neoplasms
Interventions: DRUG: Dexmedetomidine|DRUG: Sodium Chloride 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Strip Graft w/ Xenogeneic Matrix vs Free Gingival Graft for the Augmentation of Peri-implant Keratinized Mucosa
Status: RECRUITING
Conditions: Peri-Implantational Loss|Surgical Wound|Healing Surgical Wounds|Thin-gingiva
Interventions: PROCEDURE: Strip graft with Mucograft|PROCEDURE: Free gingival graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone in Preventing Hearing Loss in Patients Receiving Cisplatin
Status: WITHDRAWN
Conditions: Malignant Neoplasm|Ototoxicity
Interventions: DRUG: Dexamethasone|OTHER: Placebo|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial of SHR-A2102 With Adebrelimab With or Without Other Antitumor Therapy in Advanced or Metastatic Esophageal Cancer
Status: RECRUITING
Conditions: Advanced or Metastatic Esophageal Cancer
Interventions: DRUG: SHR-A2102；Adebrelimab；Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Inflammation Caused by Gingivitis in Adults
Status: COMPLETED
Conditions: Gingivitis
Interventions: DRUG: Triclosan/Copolymer/fluoride toothpaste|DRUG: sodium monofluorophosphate toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-PD-1 Antibody Plus Regorafenib in Refractory Microsatellite Stable Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Adenocarcinoma
Interventions: DRUG: regorafenib plus anti-PD-1 antibodies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Peer-delivered Follow-up Text Communication After a Brief Motivational Interviewing (MI) for Adolescent Drug Abusers
Status: COMPLETED
Conditions: Drug Abuse|Adolescent Behavior
Interventions: BEHAVIORAL: Brief Motivational Interviewing interaction|BEHAVIORAL: General health communication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Androgen Receptor mRNA Expression is Positively Associated With Live Birth in Women Undergoing IVF Independently of the Type of Ovarian Response
Status: COMPLETED
Conditions: Androgen Receptor Gene Overexpression|Normal Responders|Poor Ovarian Response|Bologna Criteria
Interventions: GENETIC: Real time PCR
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Zinc, Chromium, Vitamin C, and Copper Combination Supplement for Prediabetes Progression
Status: RECRUITING
Conditions: PreDiabetes|Nutrition
Interventions: DIETARY_SUPPLEMENT: Zinc, Chromium, Vitamin C, and Copper Supplementation|BEHAVIORAL: Standard healthy lifestyle intervention|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Binaural Beats for Maintenance of General Anesthesia
Status: NOT_YET_RECRUITING
Conditions: Anesthesia, General
Interventions: PROCEDURE: Silent|PROCEDURE: Binaural beats
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Safety, Tolerability, and Bioavailability of Subcutaneous Lirentelimab (AK002) in Adult Healthy Volunteers
Status: COMPLETED
Conditions: Study Conducted in Healthy Volunteers
Interventions: DRUG: lirentelimab (AK002)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of Transverse Abdominis Plane (TAP) Block in Children Undergoing Hydrocelectomy and/or Hernia Repair Surgery
Status: COMPLETED
Conditions: Hydrocele|Inguinal Hernia
Interventions: PROCEDURE: TAP block|PROCEDURE: Local Infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Role of Surgery in Patients With Focally Progressive Gastrointestinal Stromal Tumors (GISTs) After Imatinib Treatment
Status: UNKNOWN
Conditions: Gastrointestinal Stromal Tumors|Surgery
Interventions: PROCEDURE: surgery|DRUG: Imatinib 400 MG|DRUG: Imatinib escalation|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT