pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Application of 3D Printed Removable Denture Prosthesis Framework for Partial Edentulous Patients
Status: COMPLETED
Conditions: Dental Prosthesis Failure
Interventions: DEVICE: 3D Printed Denture Framework
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Bioequivalence of 2 Fixed Dose Combination (FDC) Tablets of Canagliflozin and Metformin Immediate Release (IR) (50 mg/1,000 mg) With Respect to the Individual Components of Canagliflozin (1 x 100 mg) and Metformin IR Tablets (2 x 1,000 mg) in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: A (canagliflozin and metformin IR individual tablets) / B (canagliflozin/metformin IR FDC tablets)|DRUG: B (canagliflozin/metformin IR FDC tablets / A (canagliflozin and metformin IR individual tablets)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Sipuleucel-T With Administration of Enzalutamide in Men With Metastatic Castrate-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Metastatic Prostate Cancer
Interventions: BIOLOGICAL: sipuleucel-T|DRUG: enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Tolerability Study of Oral LGD-6972 for Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: LGD-6972|DRUG: Placebo (Captisol ®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Barley Beta-glucan, Glycemic Control, and Appetite
Status: COMPLETED
Conditions: Diet, Healthy|Blood Sugar; High|Diabetes|Appetite and General Nutritional Disorders|Appetitive Behavior
Interventions: OTHER: WR|OTHER: LB|OTHER: MB|OTHER: HB|OTHER: WR+50g HFCS|OTHER: LB + 50 g HFCS|OTHER: MB + 50 g HFCS|OTHER: HB + 50 g HFCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: An in Vivo Bioequivalence Study of 2 Loxoprofen Sodium Products in Vietnamese Healthy Male Volunteers
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: FABALOFEN 60|DRUG: JAPROLOX TABLET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Toric Trifocal IOL Treatment With High Astigmatism and Hyperopia vs SMILE Enhancement After Trifocal IOL Treatment
Status: COMPLETED
Conditions: Astigmatism High Both|Pseudophakia|Hyperopia
Interventions: PROCEDURE: Toric Trifocal IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparing Pvc or Silicone Gastric Calibration Tube During Sleeve Gastrectomy
Status: UNKNOWN
Conditions: Surgery|Calibration Tube
Interventions: DEVICE: thin pvc gastric tube|DEVICE: thick silicone gastric tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of SARAH Protocol in Women With Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: OTHER: SARAH|OTHER: Educational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of a Preparation Containing an Antibiotic and Anti-Inflammatory Agent in Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: clindamycin phosphate|DRUG: salicylic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Applying pGz in Mitochondrial Disease
Status: RECRUITING
Conditions: Mitochondrial Myopathies|Mitochondrial Diseases
Interventions: DIAGNOSTIC_TEST: Cardiopulmonary Exercise Testing|DEVICE: pGz Bed|DEVICE: Gentle Jogger|DEVICE: Exercise Pedal|DRUG: Lumason® contrast agent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Carbohydrates
Status: COMPLETED
Conditions: Glycemic Index
Interventions: OTHER: CHO Control 1 and 2 Glucose|OTHER: CHO Experimental 1 Slowly Digested|OTHER: CHO Experimental 2 Digestion Resistant|OTHER: CHO Experimental 3 Low Sugar|OTHER: CHO Experimental 4 Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Impact of the Artificial Intelligence in a Telemonitoring Programme of COPD Patients With Multiple Hospitalizations
Status: UNKNOWN
Conditions: COPD
Interventions: DEVICE: Machine Learning: ML (Artificial Intelligence System)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Endoscopic Vacuum Therapy for Transmural Defects in the Upper Gastrointestinal Tract
Status: RECRUITING
Conditions: Endoscopic Vacuum Therapy|Anastomotic Leak|Esophageal Perforation|Esophageal Perforation, Traumatic|EsoSponge|VACStent
Interventions: OTHER: Observational
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Motivating Structured Walking Activity in Intermittent Claudication
Status: UNKNOWN
Conditions: Peripheral Arterial Disease|Intermittent Claudication|Peripheral Vascular Disease
Interventions: BEHAVIORAL: MOSAIC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate ARINA-1 in the Prevention of Bronchiolitis Obliterans Progression in Participants With Bilateral Lung Transplant
Status: RECRUITING
Conditions: Pre-Bronchiolitis Obliterans Syndrome
Interventions: DRUG: ARINA-1|OTHER: Standard of care only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-Label Safety Study of AXS-05 in Subjects With Depression
Status: COMPLETED
Conditions: Major Depressive Disorder|Treatment Resistant Depression|Depression
Interventions: DRUG: AXS-05 (dextromethorphan and bupropion) oral tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Online-delivered Cognitive-behavioral Intervention for Dysfunctional Worry Related to the Covid-19 Pandemic
Status: UNKNOWN
Conditions: Dysfunctional Worry
Interventions: BEHAVIORAL: Internet-delivered cognitive behavior therapy (ICBT) for dysfunctional worry related to the Covid-19 pandemic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MHAA4549A as Monotherapy for Acute Uncomplicated Seasonal Influenza A in Otherwise Healthy Adults
Status: COMPLETED
Conditions: Influenza A
Interventions: DRUG: MHAA4549A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Org 34517 900 mg in Patients Who Received Org 34517 in a Previous Trial (Study 28133/P05842)
Status: COMPLETED
Conditions: Depressive Disorders|Psychotic Disorders|Depression
Interventions: DRUG: SCH 900636|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of a Polymeric Membrane Dressing Plus Negative Pressure Wound Therapy Against Negative Pressure Wound Therapy Alone
Status: COMPLETED
Conditions: Wound
Interventions: DEVICE: WICVAC|DEVICE: VAC mono therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predicting Non-small Cell Lung Cancer (NSCLC) Lymph Node Metastasis: Integrating Circulating Tumor DNA (ctDNA) Mutation/ Methylation Profiling With Positron Emission Tomography-computed Tomography (PET-CT) Scan
Status: RECRUITING
Conditions: Carcinoma|Non-small Cell Lung Cancer
Interventions: PROCEDURE: Blood ctDNA + methylation + PET-CT and Postoperative pathology|PROCEDURE: MRD+ methylation (or combined with PET-CT) and Invasive mediastinoscopy /EBUS-TBNA|PROCEDURE: Intraoperative lymph node dissection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immune Response to SARS-CoV-2 (COVID-19) Vaccines in Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Electronic Health Record Review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intravitreal Ranibizumab in Retinal Pigment Epithelial Detachments
Status: COMPLETED
Conditions: Pigment Epithelial Detachment
Interventions: DRUG: intravitreal injection with ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Experimental Study to Validate the "Therapeutic Game" CONEM-BETA
Status: COMPLETED
Conditions: Alzheimer's Disease|Dementia
Interventions: OTHER: CONEM-BETA + socio-educational training|OTHER: Socio-educational training only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Amodiaquine in the Treatment of Uncomplicated Falciparum Malaria in Young Children of Burkina Faso
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Amodiaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Safety, Tolerability, Absorption, Distribution, Metabolism, and Elimination of RWJ-445380 Administered to Patients With Plaque Psoriasis
Status: COMPLETED
Conditions: Chronic Small Plaque Psoriasis
Interventions: DRUG: RWJ-445380
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab + Idelalisib for Lung Cancer Study
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer|Metastasis|Recurrence
Interventions: DRUG: Pembrolizumab|DRUG: Idelalisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Black Chokeberry Bio Juice on Blood Pressure Levels and Endothelial Damage
Status: ACTIVE_NOT_RECRUITING
Conditions: Essential Hypertension|Endothelial Dysfunction|Inflammation
Interventions: DIETARY_SUPPLEMENT: Black chokeberry juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Pharmacokinetics Study Of Azacitidine (SC And Oral) In Subjects With MDS, CMML, AML, Lymphoma And Multiple Myeloma
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes|Lymphoma|Multiple Myeloma|Leukemia, Myelomonocytic, Chronic
Interventions: DRUG: azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Foot Reflexology on Patients Undergoing Appendectomy Surgery
Status: COMPLETED
Conditions: Nursing|Pain|Reflexology|Abdominal Pain|Sleep Quality|Bowel Functions|Appendectomy
Interventions: OTHER: Foot Reflexology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bacterial Translocation Markers as Predictors of Infectious and Inflammatory Complications in Acute Bowel Obstruction
Status: ACTIVE_NOT_RECRUITING
Conditions: Intestinal Obstruction|Colorectal Cancer|Post-Op Complication|Systemic Inflammatory Response Syndrome|Colon Tumor
Interventions: DIAGNOSTIC_TEST: LBP|DIAGNOSTIC_TEST: sCD14-ST|DIAGNOSTIC_TEST: 16s rRNA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Diabetic Retinopathy Functional Evaluation Study: Monitoring Carotenoid Vitamins Treatment Using ERG
Status: UNKNOWN
Conditions: Diabetes|Diabetic Retinopathy
Interventions: DIETARY_SUPPLEMENT: DVS supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Safety Follow-up of Becaplermin or Placebo Gel Following Treatment of Chronic, Full Thickness Diabetic Ulcers
Status: COMPLETED
Conditions: Platelet-Derived Growth Factor|Diabetic Foot|Neoplasms
Interventions: DRUG: Sterile becaplermin gel vs. sterile placebo gel treatment 1
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Micronutrients for Attention-Deficit Hyperactivity Disorder in Youth (MADDY) Study
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: COMBINATION_PRODUCT: Broad Spectrum Micronutrients; a 36-ingredient blend of vitamins, minerals, amino acids, and antioxidants|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Carvedilol Vs Propranolol in Cirrhotic Patients With Variceal Bleeding
Status: UNKNOWN
Conditions: Liver Cirrhosis|Esophageal and Gastric Varices|Hemorrhage
Interventions: DRUG: Carvedilol|DRUG: Propranolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Comparison of the Safety and Efficacy of Two Different Regimens of Levofloxacin in the Treatment of Acute Bacterial Sinusitis(Sinus Infection) in Adults.
Status: COMPLETED
Conditions: Sinusitis
Interventions: DRUG: levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CC-97489 in Healthy Adult Participants
Status: TERMINATED
Conditions: Healthy Volunteers
Interventions: DRUG: CC-97489|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib and Pembrolizumab for the Treatment of Stage IVB Locally Advanced and Unresectable or Stage IVC Metastatic Anaplastic Thyroid Cancer
Status: RECRUITING
Conditions: Metastatic Thyroid Gland Carcinoma|Poorly Differentiated Thyroid Gland Carcinoma|Stage IVB Thyroid Gland Anaplastic Carcinoma AJCC v8|Stage IVC Thyroid Gland Anaplastic Carcinoma AJCC v8|Thyroid Gland Squamous Cell Carcinoma|Unresectable Thyroid Gland Carcinoma
Interventions: DRUG: Lenvatinib|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change
Status: RECRUITING
Conditions: Overweight|Obesity
Interventions: OTHER: Low-carbohydrate Diet|OTHER: Low-fat Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Irbesartan in the Treatment of Hypertensive Patients With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome|Hypertension
Interventions: DRUG: Irbesartan|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Trial of PXD101 (Belinostat) in Combination With Idarubicin to Treat AML Not Suitable for Standard Intensive Therapy
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: PXD101|DRUG: idarubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study of Ruxolitinib, Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma (RRMM) Patients
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Ruxolitinib Oral Tablet [Jakafi]|DRUG: Lenalidomide|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicentre Randomised Controlled Trial Comparing Two Strategies for the Diagnosis of Invasive Aspergillosis in High-risk Haematology Patients
Status: COMPLETED
Conditions: Invasive Aspergillosis
Interventions: OTHER: Culture and histology|OTHER: Aspergillus galactomannan and PCR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Drug-drug Interaction Study of SHR2150 on Healthy Chinese Volunteers
Status: UNKNOWN
Conditions: Human Immunodeficiency Virus Infection
Interventions: DRUG: SHR2150 tablet、efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial Investigating the Efficacy and Safety of Insulin Degludec/Liraglutide Injection in Subjects With Type 2 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: Insulin Degludec/liraglutide Injection|DRUG: XULTOPHY®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Empower@Home: Hybrid Effectiveness-Implementation Randomized Controlled Trial (RCT)
Status: NOT_YET_RECRUITING
Conditions: Depression
Interventions: BEHAVIORAL: Empower@Home: An online cognitive-behavioral therapy self-care program for geriatric depression|OTHER: Telephone friendly visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on Intestinal Gas Symptoms to Evaluate the Effects of Gas Defense in Otherwise Healthy Adult
Status: COMPLETED
Conditions: Abdominal Pain|Abdominal Cramps|Flatulence
Interventions: DIETARY_SUPPLEMENT: BC-130 (Gas Defense)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: The Predictability of Intraoperative Rotational Thromboelastometry on Postoperative Bleeding and Transfusion Requirements
Status: COMPLETED
Conditions: Surgery for Congenital Heart Disease|Pediatric Patients
Interventions: PROCEDURE: surgery for congenital heart disease with cardiopulmonary bypass
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multicenter Trial Investigating Performance and Safety of the Medical Device SiPore21®
Status: RECRUITING
Conditions: Overweight or Obesity
Interventions: DEVICE: IMD SiPore21®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Flaxseed Consumption and Bone Metabolism in Postmenopausal Women.
Status: UNKNOWN
Conditions: Bone Loss, Age Realted|Post Menopausal
Interventions: OTHER: Flaxseed|OTHER: Placebo control porridge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Organ Preservation Strategy of Total Neoadjuvant Chemoradiotherapy for Low Rectal Carcinoma
Status: RECRUITING
Conditions: Rectal Cancer
Interventions: COMBINATION_PRODUCT: Total Neoadjuvant Chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 1454GCC: Anti-PD-1 (MK-3475) and IMiD (Pomalidomide) Combination Immunotherapy in Relapsed/Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: MK-3475|DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MT10109L in the Treatment of Glabellar Lines
Status: COMPLETED
Conditions: Glabellar Lines
Interventions: DRUG: MT10109L|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Independent Effects of High-cholesterol (High-egg) and High-saturated Fat Diets on LDL-cholesterol
Status: COMPLETED
Conditions: Hypercholesterolemia|Hyperlipidemias|Physical Inactivity|Diet, Healthy
Interventions: OTHER: Egg diet|OTHER: Egg-free Diet|OTHER: Control Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison Between D&C and Hysteroscopy in Management of AUB in Perimenopausal Women
Status: COMPLETED
Conditions: Uterine Bleeding
Interventions: PROCEDURE: D&C|PROCEDURE: Hysteroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Trastuzumab (Herceptin), Bevacizumab, and Docetaxel (Taxotere) Trial in Stage IV Metastatic Breast Cancer (MBC) Patients
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab|DRUG: Bevacizumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Effect of Food on the Pharmacokinetics of Meloxicam After Single Administration and to Investigate Dose-proportionality Over a Dosage Range
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Meloxicam - low dose|DRUG: Meloxicam - medium dose|DRUG: Meloxicam - high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IN10018 Combination Therapy in Previously-treated Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: IN10018|DRUG: Nab-paclitaxel|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Inflammation, Immunity, Islet Cell and Intestinal Hormone Changes in Youth at Risk for Diabetes
Status: COMPLETED
Conditions: Obesity|PreDiabetes|Adolescent Obesity|Inflammation|Metabolic Problems|Insulin Resistance|Gut Microbiome|Immunity|Beta Cell Dysfunction|Gut Hormones
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comprehensive Third-generation Intervention for People With Psychosis and Post-traumatic Stress Symptoms
Status: ENROLLING_BY_INVITATION
Conditions: Trauma, Psychological|Psychosis
Interventions: BEHAVIORAL: TAU + A comprehensive third-generation intervention|BEHAVIORAL: TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Risperidone for the Prevention of Mood Episodes in the Treatment of Patients With Bipolar I Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Olanzapine|DRUG: Placebo|DRUG: Risperidone Long Acting Injectable (LAI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Different Doses of Atevirdine Mesylate Plus Zidovudine in HIV-Positive Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Atevirdine mesylate|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: BRCA 1/2 Status as a Predictive Factor to Response to Platinum Based Chemotherapy in Cancer Ovary
Status: NOT_YET_RECRUITING
Conditions: Ovarian Cancer
Interventions: BEHAVIORAL: Assess the response to platinum-based chemotherapy in correlation to BRCA status in neoadjuvant and recurrent ovarian cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nicotinamide Riboside Supplementation In Progressive Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis|Progressive Multiple Sclerosis
Interventions: DIETARY_SUPPLEMENT: Nicotinamid riboside|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of the CADenceTM System in Detection of Coronary Artery Diseases
Status: WITHDRAWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: CADence System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial of Local Lidocaine Gel and Intrauterine Lidocaine Infusion for Pain Relief During Saline Infusion Sonohysterography
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Intrauterine lidocaine|DRUG: Lidocaine gel|DRUG: KY jelly|DRUG: Intrauterine normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tranexamic Acid Instillation in Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Postoperative Complications
Interventions: DRUG: Tranexamic Acid 500 MG|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of 2LHERP® in Genital Herpes Infections
Status: TERMINATED
Conditions: Herpes Simplex, Genital
Interventions: DRUG: 2LHERP®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Repetitive Use of 24-hour Levosimendan Infusions in Patients With Severe Systolic Heart Failure in Order to Prevent Rehospitalizations
Status: UNKNOWN
Conditions: Systolic Heart Failure
Interventions: DRUG: Levosimendan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Infant Formula Trial on Dietary Management of Infantile Colic
Status: TERMINATED
Conditions: Infantile Colic
Interventions: OTHER: Specific hydrolysed proteins|OTHER: Standard cow's milk with prebiotics mixture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Peppermint Oil on Nausea, Vomiting and Retching in Cancer Patients Undergoing Chemotherapy
Status: COMPLETED
Conditions: Chemotherapy Effect|Adverse Effect|Nursing Caries
Interventions: OTHER: aromatherapy (peppermint oil)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tranexamic Acid and Spontaneous Chronic Urticaria
Status: UNKNOWN
Conditions: Chronic Spontaneous Urticaria
Interventions: DRUG: association of levocetirizine and tranexamic acid|DRUG: Levocetirizine only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Liposomal Glutathione Supplementation in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Low dose oral liposomal glutathione supplementation|OTHER: High dose oral liposomal glutathione supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: EACH: Evaluating Avelumab in Combination With Cetuximab in Head and Neck Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer|Squamous Cell Carcinoma
Interventions: DRUG: Avelumab|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of Metronidazole Capsules Under Fed Conditions
Status: COMPLETED
Conditions: To Determine the Bioequivalence Study Under Fed
Interventions: DRUG: Metronidazole|DRUG: Flagyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Safety and Efficacy of CC-4047 in Subjects With Metastatic Hormone Refractory Prostate Cancer (HRPC)
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: CC-4047
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: T-Cat Laser & Cross-linking for Keratoconus
Status: COMPLETED
Conditions: Keratoconus|Pellucid Marginal Degeneration
Interventions: PROCEDURE: Excimer laser ablation, and collagen cross-linking
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Diabetes-specific Formula in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Nutren Diabetes|OTHER: Isocaloric
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Remote Ischaemic Conditioning on Clinical Outcomes in STEMI Patients Undergoing PPCI (CONDI2/ERIC-PPCI)
Status: COMPLETED
Conditions: STEMI|Myocardial Reperfusion Injury
Interventions: DEVICE: Remote ischemic conditioning|DEVICE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Breakthrough CINV in Patients Receiving Moderately or Highly Emetogenic Chemotherapy
Status: RECRUITING
Conditions: Chemotherapy Induced Nausea and Vomiting
Interventions: DRUG: Akynzeo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Alkotinib Capsule in Patients With ALK-positive Non-small Cell Lung Cancer Previously Treated With Crizotinib
Status: TERMINATED
Conditions: ALK-positive Non-small Cell Lung Cancer
Interventions: DRUG: Alkotinib Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Doxycycline in Patients With Non-Ischemic Cardiomyopathy
Status: TERMINATED
Conditions: Non-ischemic Cardiomyopathy|Systolic Heart Failure (NYHA II-III)
Interventions: DRUG: Doxycycline|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bone Loss in Melanoma Survivors Receiving Immunotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Clinical Stage III Cutaneous Melanoma AJCC v8|Clinical Stage IV Cutaneous Melanoma AJCC v8|Pathologic Stage III Cutaneous Melanoma AJCC v8|Pathologic Stage IIIA Cutaneous Melanoma AJCC v8|Pathologic Stage IIIB Cutaneous Melanoma AJCC v8|Pathologic Stage IIIC Cutaneous Melanoma AJCC v8|Pathologic Stage IIID Cutaneous Melanoma AJCC v8|Pathologic Stage IV Cutaneous Melanoma AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Dual X-ray Absorptiometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of NTX-001 in the Treatment and Prevention of Facial Paralysis Requiring Surgical Repair.
Status: TERMINATED
Conditions: Facial Paralysis
Interventions: COMBINATION_PRODUCT: NTX-001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of BMS-770767 in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Type 2
Interventions: DRUG: BMS-770767|DRUG: BMS-770767|DRUG: BMS-770767|DRUG: BMS-770767|DRUG: Placebo|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation on the Efficacy of WO 2085 Moisturising Cream for Breast Cancer Patients Suffering From Vulvovaginal Dryness
Status: COMPLETED
Conditions: Vulvovaginal Atrophy
Interventions: DEVICE: WO2085 Moisturising Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Efficacy and Safety of SAR442970 in Adults With Hidradenitis Suppurativa
Status: ACTIVE_NOT_RECRUITING
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: SAR442970|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and the Body's Ability to Develop Resistance to an Investigational Vaccine for Shingles (V211-007)
Status: COMPLETED
Conditions: Shingles
Interventions: BIOLOGICAL: zoster vaccine live (Oka/Merck)|BIOLOGICAL: Comparator: placebo (unspecified)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Impact on Skin (Injection Site) Reactions of Using Alcohol Wipes Prior to Daily Injections of Copaxone®.
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: PROCEDURE: Alcohol Wipes vs. No Alcohol Wipes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial to Compare Blood Concentration Levels of Semaglutide Following Subcutaneous Injections of Semaglutide 1 mg by 2 Different Devices (the DV3372 Device and by the PDS290 Semaglutide Pen-injector)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide, 0.25 mg|DRUG: Semaglutide, 0.5 mg|DRUG: Semaglutide, 1.0 mg|DEVICE: DV3372|DEVICE: PDS290 pen-injector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Prophylactic Pre Operative Probiotic Therapy on Endotoxin Levels in Cardiac Surgery Patients
Status: WITHDRAWN
Conditions: Preoperative Cardiac Surgery Patients
Interventions: DRUG: Lactobacillus Probiotic|OTHER: Lactose Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability of an Intravenous Infusion of ACZ885 in Patients With Wet Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Wet Age-Related Macular Degeneration
Interventions: DRUG: ACZ885
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Bevacizumab for Low Vision in Neovascular Age-related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Age Related Macular Degeneration
Interventions: DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Seladelpar in Subjects With Nonalcoholic Steatohepatitis (NASH)
Status: TERMINATED
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: DRUG: Seladelpar|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on ASTRA TECH Implant System, OsseoSpeed™ Implants in Patients Missing All Teeth in the Upper Jaw, Restored With Provisional Teeth Within 24 Hours
Status: COMPLETED
Conditions: Jaw, Edentulous
Interventions: DEVICE: ASTRA TECH Implant System, OsseoSpeed™, all dimensions.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use
Status: RECRUITING
Conditions: Cannabis Use|Tobacco Use Disorder|Drug Use Disorder
Interventions: DRUG: N-Acetyl cysteine|OTHER: Placebo comparator|BEHAVIORAL: Cognitive behavioral therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis
Status: RECRUITING
Conditions: Myasthenia Gravis
Interventions: DRUG: Nipocalimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of a Novel Non-Invasive, Non-Touch Infrared Thermometer With Routine Thermometry in Routine Clinical Practice
Status: COMPLETED
Conditions: Healthy|Febrile
Interventions: DEVICE: ARC InstaTemp MD|DEVICE: Covidien Genius 2 Tympanic Thermometer|DEVICE: Welch Allen SureTemp Plus Sublingual Thermometer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Effects of PEEP on Parameters of Tissue Perfusion in Patients Post Cardiac Surgery
Status: UNKNOWN
Conditions: Coronary Artery Disease|Coronary Artery Bypass Grafting|Acute Lung Injury
Interventions: OTHER: Group G5|OTHER: Group G10|OTHER: Group G15
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of DTaP-IPV-Hep B-PRP-T Vaccine Given With Prevenar™ and Rotarix™ in Healthy Latin American Infants
Status: COMPLETED
Conditions: Diphtheria|Tetanus|Whooping Cough|Hepatitis B|Poliomyelitis
Interventions: BIOLOGICAL: DTaP-IPV-Hep B-PRP-T Vaccine|BIOLOGICAL: DTaP-IPV-Hep B-PRP-T Vaccine|BIOLOGICAL: DTaP-IPV-Hep B-PRP-T Vaccine|BIOLOGICAL: DTaP-Hep B-IPV vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cognitive Reappraisal Training for Borderline Personality
Status: COMPLETED
Conditions: Borderline Personality Disorder
Interventions: BEHAVIORAL: Cognitive Reappraisal by Distancing|BEHAVIORAL: Control Downregulate Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Trial of AAV Gene Therapy in Patients With CNGB3 Achromatopsia (A Clarity Clinical Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Achromatopsia
Interventions: BIOLOGICAL: rAAV2tYF-PR1.7-hCNGB3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sedation in Patients at Risk for Upper Airway Collapse
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: Propofol|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: R(+)XK469 in Treating Patients With Advanced Neuroblastoma
Status: COMPLETED
Conditions: Disseminated Neuroblastoma|Localized Unresectable Neuroblastoma|Recurrent Neuroblastoma|Regional Neuroblastoma
Interventions: DRUG: R(+)XK469
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Stability of Dexmedetomidine Sedation Compared to Propofol Sedation in the Drug Induced Sleep Endoscopy
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: Propofol Fresenius|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Patient-reported Pain After Initial Archwire Placement
Status: RECRUITING
Conditions: Orthodontic Discomfort|Pain, Orofacial
Interventions: DEVICE: 3M Unitek 0.016 orthodontic archwire|DEVICE: Device: 0.016" Ormco 27oC NiTi orthodontic archwire|DEVICE: Device: 0.016" Ormco 35oC NiTi orthodontic archwire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Trial of Probiotics for Constipation in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Probiotic Capsule|DRUG: Placebo Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Psychotherapy for Relapse Prevention in Early Adulthood (< 35 yr.) of Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: BEHAVIORAL: SEKT - Cognitive-Behavioral-Emotional|BEHAVIORAL: FEST - Clinical Supportive Educational
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Aussie Current in Patients With Knee Osteoarthritis.
Status: UNKNOWN
Conditions: Osteoarthritis, Knee|Quadriceps Muscle Atrophy
Interventions: OTHER: Electrical electrostimulation of the quadriceps muscle|OTHER: Electrical electrostimulation of the quadriceps muscle (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Laparoscopic Totally Extraperitoneal (TEP) and Lichtenstein Technique
Status: COMPLETED
Conditions: Hernia, Inguinal
Interventions: PROCEDURE: inguinal hernia repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endothelium, Stenting, and Antiplatelet Therapy (EST) - Clopidogrel, Prasugrel, Ticagrelor Study
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Coronary stenting|DRUG: Ticagrelor|DRUG: Clopidogrel|DRUG: Prasugrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Olaratumab Plus Trabectedin in Advanced Soft-tissue Sarcoma Patients Soft-tissue Sarcoma Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Sarcoma, Soft Tissue
Interventions: DRUG: Olaratumab and Trabectedin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic-Assisted Resection or Open Resection in Treating Patients With Rectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: PROCEDURE: Open laparotomy and rectal resection|PROCEDURE: Laparoscopic-assisted rectal resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study To Assess The Effect Of Gabapentin, Diphenhydramine And Morphine On Cold Pain In Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Gabapentin|DRUG: Diphenhydramine|DRUG: Morphine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Comparison of the Safety and Pharmacokinetics of Two SAR153191 (REGN88) Drug Products in Rheumatoid Arthritis Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: SAR153191 (REGN88)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Efficacy and Safety of PMF104 Compared to a Conventional PEG-electrolyte Solution in Children
Status: UNKNOWN
Conditions: Bowel Preparation Before Colonoscopy
Interventions: DRUG: PMF104|DRUG: Klean-prep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamics Modeling to Optimize Dosage Regimens of Sulbactam in Patients With Acinetobacter Infections
Status: COMPLETED
Conditions: Acinetobacter Infections
Interventions: DRUG: Sulbactam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Compound 31543 (Calcitriol, USP) in Patients Receiving Taxane-based Chemotherapy Regimens for Advanced or Recurrent Disease
Status: COMPLETED
Conditions: Breast Cancer|Cervical Cancer|Endometrial Cancer|Ovarian Cancer|Primary Peritoneal Carcinoma|Bone Sarcoma|Cancer|Solid Tumor
Interventions: DRUG: compound 31543 Calcitriol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION