pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: GF-NOURISH (Gluten Free Nutrition Optimization Through Ultra-processed Food Reduction and Improved Strategies for Health)
Status: NOT_YET_RECRUITING
Conditions: Celiac Disease in Children|Nutrition Disorder, Child
Interventions: OTHER: Gluten-Free Diet Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Analysis of Radiological Features of Lateral Femoral Impaction Fracture / Lateral Femoral Notch Sign
Status: RECRUITING
Conditions: Anterior Cruciate Ligament Injuries|Anterior Cruciate Ligament Rupture|Anterior Cruciate Ligament Tear
Interventions: DIAGNOSTIC_TEST: Measurements on knee MRI performed during routine clinical practice
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety and Tolerability of ABT-614 and Its Effect on Kidney Function in Subjects With Type 2 Diabetes and Chronic Kidney Disease With Protein in Their Urine.
Status: COMPLETED
Conditions: Type 2 Diabetics, Chronic Kidney Disease, Protein in Urine
Interventions: DRUG: ABT-614|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Drug-drug Interaction Study of Famitinib Malate With a Proton Pump Inhibitor in Healthy Adult Subjects
Status: COMPLETED
Conditions: Tumor
Interventions: DRUG: famitinib、omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Wound Healing Endpoint and Recurrence
Status: SUSPENDED
Conditions: Chronic Wound|Burn Wound|Diabetic Foot Ulcers|Pressure Ulcers|Venous Leg Ulcers|Chronic|Wound
Interventions: DEVICE: Epiceram Skin Barrier Function|BIOLOGICAL: Vaseline Petroleum Jelly|BIOLOGICAL: Ceramiseal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Optimal Dose of Early Intervention to Prevent PTSD
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: 1-Session Exposure Therapy|BEHAVIORAL: 3-Session Exposure Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Application of Palliative Treatment in Children With Brain Stem Glioma and Recurrent High-grade Tumors in the Central Nervous System With the Nanomaterial NPt-Ca
Status: COMPLETED
Conditions: Brain Tumor, Pediatric, Brainstem Glioma|Brain Tumor, Pediatric, Recurrent
Interventions: DRUG: Platinum acetylacetonate (1% wt) supported by sol-gel technology functionalized titania
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A/H5N1 Virus-Like Particle Antigen Dose Ranging Study With Adjuvant 1
Status: COMPLETED
Conditions: Influenza (Pandemic)
Interventions: BIOLOGICAL: Monovalent Avian Influenza VLP (H5N1)|BIOLOGICAL: Monovalent Avian Influenza VLP (H5N1)|BIOLOGICAL: Monovalent Avian Influenza VLP (H5N1); Adjuvant|BIOLOGICAL: Monovalent Avian Influenza VLP (H5N1); Adjuvant|BIOLOGICAL: Monovalent Avian Influenza VLP (H5N1); Adjuvant|BIOLOGICAL: Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Efficacy and Safety of Lenvatinib Combined With Tislelizumab in Patients With FHRCC
Status: RECRUITING
Conditions: Fumarate Hydratase Deficient Renal Cell Carcinoma
Interventions: BIOLOGICAL: Tislelizumab|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Clinical Trial of Y-2 Sublingual Tablets in the Treatment of Acute Ischemic Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: Y-2 sublingual tablets|DRUG: d-borneol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Biological Features Between pN0 Triple Negative Breast Tumours With Size < or = 10 mm (pT1a/b) Versus pT1c T2 < or = 30 mm
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple Negative Breast Cancers Without Lymph-node Involvement and < or = 30 mm
Interventions: PROCEDURE: Blood samples of 10 mL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluate the Efficacy and Safety of HLX01 Versus Mabthera in Patients With Low Tumour Burden Follicular Lymphoma.
Status: WITHDRAWN
Conditions: CD20-positive Follicular Lymphoma, With Low Tumour Burden
Interventions: DRUG: HLX01|DRUG: Mabthera®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alternative Sedation During Bronchoscopy
Status: COMPLETED
Conditions: Sedation
Interventions: DRUG: Dexmedetomidine load|DRUG: Ketamine load|DRUG: Midazolam load|DRUG: Fentanyl load|DRUG: Dexmedetomidine maintenance|DRUG: Ketamine maintenance|DRUG: Midazolam demand|DRUG: Fentanyl demand|DRUG: Benadryl demand
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Sexual Function After Myocardial Infarction
Status: RECRUITING
Conditions: Sexual Function Disturbances|Myocardial Infarction
Interventions: OTHER: Information film
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of STARgraft-3 for Hemodialysis
Status: ACTIVE_NOT_RECRUITING
Conditions: End Stage Renal Disease
Interventions: DEVICE: Implant of STARgraft-3 shunt in the upper arm and subsequent use for hemodialysis access
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of PHN131 in Patients After Surgery
Status: COMPLETED
Conditions: Analgesia Disorder
Interventions: DRUG: PHN131 soft capsule with Nalbuphine HCl 60 mg/cap|DRUG: Placebo soft capsules|DRUG: Dicofenac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Hypnotic Medication Discontinuation in Primary Care
Status: NOT_YET_RECRUITING
Conditions: Insomnia|Hypnotic Dependence
Interventions: BEHAVIORAL: Digital Cognitive Behavioral Therapy|BEHAVIORAL: Structured Medication Tapering
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Response to Pembrolizumab in Metastatic Melanoma: Computed Tomography Texture Analysis as a Predictive Biomarker
Status: TERMINATED
Conditions: Metastatic Melanoma
Interventions: DRUG: Pembrolizumab|PROCEDURE: CT Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Cerebrolysin on the Blood Brain Barrier in Patients With Diabetes and Ischemic Stroke
Status: RECRUITING
Conditions: Ischemic Stroke, Acute|Diabetes Mellitus, Type 2|Blood Brain Barrier
Interventions: DRUG: Cerebrolysin|PROCEDURE: Brain-MRI with contrast after 10-14 days of cerebrolysin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study Evaluating the Efficacy and Safety of ARTISS Human Fibrin Sealant as Used in External Rhinoplasty
Status: COMPLETED
Conditions: Subjects Requesting and Requiring an Open Rhinoplasty
Interventions: BIOLOGICAL: ARTISS human fibrin sealant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determination of the Relative Bioavailability of ARQ 197 Tablet Formulation With Capsule C Formulation as a Reference in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Tivantinib (ARQ 197) Capsule|DRUG: Tivantinib (ARQ 197) Tablet|DRUG: Tivantinib (ARQ 197) Capsule D, oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Traction Assisted Polypectomy of the Intestine
Status: COMPLETED
Conditions: Colonic Polyps|Adenomatous Polyps
Interventions: DEVICE: traction assisted endoscopic mucosa resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term KRd in Relapsed and/or Refractory Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma in Relapse|Multiple Myeloma, Refractory
Interventions: DRUG: Carfilzomib|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Medical Device Pivotal Study to Injection With SkinPlus-HYAL Implant Lidocaine vs RESTYLANE Lidocaine in of Nasolabial Folds
Status: ENROLLING_BY_INVITATION
Conditions: Nasal Disease|Nasal Surgery
Interventions: DEVICE: Investigational medical device (SkinPlus-HYAL Implant Lidocaine)|DEVICE: Active Comparator: Active Comparator Medical Device (RESTYLANE Lidocaine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Perspective Multicenter Controlled Study On Application Of Mesenchymal Stem Cell(MSC) To Prevent Rejection After Renal Transplantation By Donation After Cardiac Death
Status: UNKNOWN
Conditions: Disorder Related to Renal Transplantation|Renal Transplant Rejection
Interventions: BIOLOGICAL: mesenchymal stem cell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Foot in Your Nose Study: Links Between Nasal Staphylococcus Aureus Colonies and Diabetic Foot Lesion Infections
Status: COMPLETED
Conditions: Diabetic Foot|Staphylococcus Aureus
Interventions: BIOLOGICAL: Genetic profiling of bacterial cultures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Virtual Reality and Acupressure Applications; Effect on Pain, Anxiety, Vital Signs and Comfort
Status: COMPLETED
Conditions: Pain|Anxiety|Vital Signs|Virtual Reality
Interventions: PROCEDURE: Virtual Reality|PROCEDURE: Acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Potassium Citrate in the Treatment of Postmenopausal Osteopenia
Status: COMPLETED
Conditions: Osteopenia|Bone Disease, Metabolic
Interventions: DIETARY_SUPPLEMENT: Potassium citrate|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Calcium carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Safety and Efficacy of USL261 (Intranasal Midazolam) in Patients With Seizure Clusters
Status: TERMINATED
Conditions: Epilepsy
Interventions: DRUG: USL261|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction Study Between Raltegravir And UK-453,061
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: UK-453,061|DRUG: UK-453,061|DRUG: Raltegravir|DRUG: Raltegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Non-dispensing Fit Evaluation of Investigational Limbal Ring Soft Contact Lenses With Polyvinylpyrrolidone (PVP) in Asian Eyes
Status: COMPLETED
Conditions: Vision Correction
Interventions: DEVICE: etafilcon A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Testing/Transmission, and Outcomes in Pregnancies With COVID-19
Status: ACTIVE_NOT_RECRUITING
Conditions: Covid19|Pregnancy Related|Maternal Complication of Pregnancy|Coronavirus|Neonatal Infection|Prenatal Stress|Preterm Birth
Interventions: DIAGNOSTIC_TEST: Antibody testing for SARS-CoV-2 IgG|DIAGNOSTIC_TEST: Testing for SARS-CoV-2 RNA|DIAGNOSTIC_TEST: Testing for SARS-CoV-2 IgM/IgG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Pulsed Mode Radiofrequency as a Treatment of Lumbar Disc Related Radicular Pain on Tumor Necrotic Factor α Level
Status: COMPLETED
Conditions: Lumbar Disc Herniation
Interventions: PROCEDURE: Radiofrequency pulsed mode on dorsal root ganglion combined with transforaminal steroids injection|DRUG: Transforaminal injection of Steroids alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Silver Spike Point Therapy on Pelvic Girdle Pain PAIN
Status: COMPLETED
Conditions: Pelvic Girdle Pain
Interventions: DEVICE: Silver Spike Point Therapy (SSPT)|OTHER: Conservative Managment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platform Switching vs Regular Platform Implants. One Year Results From a RCT
Status: COMPLETED
Conditions: Missing Teeth
Interventions: DEVICE: Nobel Replace Tapered Groovy implant; (Nobel Biocare®, Sweden)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyaluronan Versus NaCl 20 Ml Versus Placebo in Knee Osteoarthritis
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Injection of Hyaluronan or Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Non-inferiority Trial of Iontophoretic Corneal Collagen Crosslinking (CXL) Compared to Standard Corneal Collagen Crosslinking in Progressive Keratoconus.
Status: TERMINATED
Conditions: Progressive Keratoconus
Interventions: DEVICE: Iontophoretic CXL|DEVICE: Standard CXL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test a New Decongestant in Patients With Allergic Rhinitis Following a Nasal Allergen Challenge
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Placebo|DRUG: Allegra|DRUG: Allegra-D|DRUG: PF-03654746
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Almond Dose Response Study.
Status: COMPLETED
Conditions: Hyperlipidemia|Diet Therapy|Cardiovascular Disease
Interventions: PROCEDURE: Full dose almonds|PROCEDURE: Half dose almonds+half dose muffin|PROCEDURE: Full dose whole wheat muffin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Health Education for Preventing Falls in Older Adults Living in the Community
Status: NOT_YET_RECRUITING
Conditions: Accidental Falls|Older Adults
Interventions: BEHAVIORAL: Fall prevention knowledge education|BEHAVIORAL: Exercise education|BEHAVIORAL: Home hazard reduction education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of [18F] FMH3 and PET as a Marker of Histamine-3 Receptor Activity in Subjects With AD Compared w/ HC
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: [18F]-FMH3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Transvaginal Versus Transabdominal Extraction of Laparoscopically-excised Kidney Specimen
Status: UNKNOWN
Conditions: Urologic Neoplasms
Interventions: PROCEDURE: Transvaginal natural orifice specimen extraction (NOSE)|PROCEDURE: Transabdominal specimen extraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fluciclovine F18 PET/CT in Identifying the Origin of Head and Neck Squamous Cell Carcinoma in Patients With Metastatic Cervical Nodal Disease
Status: COMPLETED
Conditions: Metastatic Head and Neck Squamous Cell Carcinoma|Metastatic Squamous Cell Carcinoma in Cervical Lymph Node
Interventions: PROCEDURE: Computed Tomography|RADIATION: Fluciclovine F18|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: One Versus Twice Daily Administration of Multiple Cardiovascular Agents in Patients With Ischemic Heart Disease
Status: UNKNOWN
Conditions: Ischemic Heart Disease
Interventions: DRUG: Aspirin, Atorvastatin, Perindopril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open,Single-centre Pilot Study of Efficacy and Safety of Topical MOB015B in the Treatment of Distal Subungual Onychomycosis (DSO)
Status: COMPLETED
Conditions: Distal Subungual Onychomycosis
Interventions: DRUG: MOB015B
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Montelukast Use in Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Montelukast|DRUG: Placebo|DRUG: Conventional DMARDs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mesotherapy Treatment of Irritable Bowel Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Inflammatory Bowel Diseases
Interventions: DRUG: Mesotherapy with mesocaine, thiocolchicoside, amitriptyline, magnesium pidolate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of AK117 in Combination With Azactidine Plus Venetoclax in Patients With Acute Myeloid Leukemia
Status: NOT_YET_RECRUITING
Conditions: ACUTE MYELOID LEUKEMIA; AML
Interventions: DRUG: AK117|DRUG: Azacitidine|DRUG: Venetoclax|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of LO2A Eye Drops for Symptomatic Improvement of Dry Eye in Patients With Sjögren's Syndrome
Status: COMPLETED
Conditions: Dry Eye Due to Sjögren's Syndrome
Interventions: DRUG: LO2A eye drops|DRUG: Systane Ultra UD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Education Based on the Chronic Care Model (StrokeCARE) in Patients With Ischemic Stroke
Status: COMPLETED
Conditions: Stroke, Ischemic|Self Efficacy
Interventions: BEHAVIORAL: The effect of education and telephone follow ups based on the Chronic Care Model on self-management, quality of life and patient satisfaction in patients with ischemic stroke
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Repetitive Transcranial Magnetic Stimulation (rTMS) for Tinnitus
Status: COMPLETED
Conditions: Tinnitus
Interventions: DEVICE: transcranial magnetic stimulation (Magstim rapid2)|DEVICE: sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Determine the Activity and Mechanisms of Cranberries to Attenuate Skin Photoaging and Improve Skin Health in Women
Status: COMPLETED
Conditions: Skin Health
Interventions: OTHER: Cranberry juice|OTHER: Placebo juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessing the Impact of Weighted Blankets on Anxiety Among Inpatients With Anorexia Nervosa: a Study Protocol
Status: COMPLETED
Conditions: Anorexia Nervosa|Avoidant/Restrictive Food Intake Disorder|Anxiety
Interventions: OTHER: Weighted blanket
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mechanism of Action Trial of ColoAd1
Status: COMPLETED
Conditions: Resectable Colon Cancer|Resectable Non-small Cell Lung Cancer|Resectable Bladder Cancer|Resectable Renal Cell Carcinoma
Interventions: BIOLOGICAL: Colo-Ad1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Potassium Copetitive Acid Blockers Efficacy in H.Pylori Eradication
Status: COMPLETED
Conditions: Helicobacter Pylori Eradication
Interventions: DRUG: Vonoprazan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HOME COOKING: Health Empowerment Strategy in People With Type II Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Mediterranean diet-based culinary intervention|BEHAVIORAL: Mediterranean diet-based nutritional education intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of the IL-1 Antagonist Anakinra for the Treatment of Endometriosis Related Symptoms
Status: UNKNOWN
Conditions: Endometriosis|Anakinra|Markers of Inflammation
Interventions: DRUG: Anakinra 100Mg/0.67Ml Inj Syringe|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Capecitabine In Combination With Docetaxel vs Capecitabine Followed by Docetaxel As First-Line Treatment For Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: XELODA [capecitabine]
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Efficacy and Safety of Fasinumab for the Treatment of Adults With Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: Fasinumab|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AARDVARK (Aortic Aneurysmal Regression of Dilation: Value of ACE-Inhibition on RisK)
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: DRUG: perindopril arginine|DRUG: amlodipine 5mgs|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Schroth Method and Proprioceptive Neuromuscular Facilitation Technique in Patients With Idiopathic Scoliosis
Status: UNKNOWN
Conditions: Idiopathic Scoliosis
Interventions: OTHER: Schroth exercises|OTHER: PNF technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial in Assigning of Tacrolimus Dosage Regimen According to CYP3A5 Genotype in Kidney Transplant Recipients
Status: UNKNOWN
Conditions: Kidney Transplantation
Interventions: GENETIC: Genotype guided|GENETIC: Conventional
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Electronic Cigarette Smoking on the Arterial Wall and Endothelial Glycocalyx Properties of Smokers
Status: UNKNOWN
Conditions: Smoking Cessation
Interventions: OTHER: Electronic cigarette|OTHER: Conventional cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial for Patients With Newly Diagnosed Primary Central Nervous System (CNS) Lymphoma
Status: COMPLETED
Conditions: Central Nervous System Lymphoma
Interventions: DRUG: Methotrexate|DRUG: Ara-C|DRUG: Rituximab|DRUG: Thiotepa|RADIATION: radiotherapy|DRUG: BCNU|OTHER: APBSCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Assess the Safety of PEG-Hirudin (SPP200) Compared to Heparin in Patients Who Are on Haemodialysis
Status: COMPLETED
Conditions: Chronic Kidney Failure|Vascular Graft Occlusion
Interventions: DRUG: PEG-hirudin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Effect of AVE0657 in Cheynes-Stokes Breathing Syndrome Patients
Status: TERMINATED
Conditions: Heart Failure|Sleep Apnea Syndromes|Cheyne-Stokes Respiration
Interventions: DRUG: AVE0657|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Music Therapy and Nicotine Replacement Therapy on Craving Related to Smoking Cessation in Students
Status: RECRUITING
Conditions: Smoking Cessation
Interventions: OTHER: Music Intervention|DRUG: Nicotine replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Early Versus Late Catheter Removal in Patients With Acute Urinary Retention Secondary to BPH Under Tamsulosin Treatment
Status: COMPLETED
Conditions: BPH With Urinary Obstruction
Interventions: PROCEDURE: Early catheter removal|PROCEDURE: Late catheter removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy Study Comparing VisionScope Imaging (VSI) to Magnetic Resonance Imaging (MRI) in Injuries of the Knee
Status: COMPLETED
Conditions: Meniscus Tears|Loose Bodies|Articular Osteoarthritis|Articular or Capsular Trauma
Interventions: PROCEDURE: VisionScope Imaging (VSI) Exam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Compare the Safety, Tolerability, and Pharmacokinetics of CTP-692 Versus D-serine in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: CTP-692|DRUG: D-Serine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tumor Response to Pemetrexed Disodium in Patients With Stage III or Stage IV Non-Small Cell Lung Cancer Enrolled in Clinical Trial MCCRC-RC0524
Status: COMPLETED
Conditions: Lung Cancer
Interventions: GENETIC: gene expression analysis|GENETIC: polymorphism analysis|GENETIC: protein expression analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Injections of Botulinum Toxin and Topical Nitroglycerin Ointment for the Treatment of Chronic Anal Fissure
Status: RECRUITING
Conditions: Fissure in Ano
Interventions: PROCEDURE: Botulinum injection|DRUG: GTN OINTMENT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Doxycycline Host-directed Therapy to Improve Lung Function and Decrease Tissue Destruction in Pulmonary Tuberculosis
Status: RECRUITING
Conditions: Tuberculosis
Interventions: DRUG: Doxycycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optical Coherence Tomography (OCT) Evaluation of Re-endothelization: A Comparison of the Intrepide™ Stent Versus Taxus™
Status: UNKNOWN
Conditions: Coronary Artery Disease|Acute Coronary Syndrome
Interventions: DEVICE: Intrepide Trapidil eluting stent|DEVICE: Taxus drug eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treatment Protocol for the Use of Sorafenib in Patients With Advanced Renal Cell Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Sorafenib (Nexavar, BAY43-9006)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About the Safety of BIIB091 and Its Effect on Brain Inflammation When Taken Alone or With Diroximel Fumarate (DRF) in Adults With Relapsing Forms of Multiple Sclerosis (MS)
Status: RECRUITING
Conditions: Relapsing Forms of Multiple Sclerosis
Interventions: DRUG: BIIB091|DRUG: DRF|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Cystic Fibrosis Patients With P. Aeruginosa
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: AZLI 75 mg two times a day (BID)/three times a day (TID)|DRUG: Placebo two times a day (BID)/three times a day (TID)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Hip Strengthening Exercises and Core Stability Exercises in Patients With Knee Osteoarthritis
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: OTHER: Assigned Interventions|OTHER: Conventional Physical Therapy and Routine Knee Exercises with Hip Strengthening Exercises.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pragmatic Trial Integrating Homelessness Diversion Services Into an Emergency Department Discharge System
Status: ENROLLING_BY_INVITATION
Conditions: Homelessness
Interventions: BEHAVIORAL: Homeless diversion (HD)|BEHAVIORAL: Treatment-as-usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Predictors and Outcomes of Kangaroo Mother Care: A Quasi-Experimental Study in Pakistan
Status: COMPLETED
Conditions: Low Birth Weight Infants|Preterm Infants
Interventions: BEHAVIORAL: Kangroo mother care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: THE EFFECT OF FAST WEIGHT EFFICIENCY AFTER LAPAROSCOPIC SLEEVE GASTRECTOMY ON THE COBB ANGLE IN MORBID OBESE PATIENTS
Status: UNKNOWN
Conditions: Obesity, Morbid|Back Pain|Scoliosis
Interventions: DIAGNOSTIC_TEST: Cobb angle measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iron and COVID-19 Vaccine Response
Status: COMPLETED
Conditions: Iron Deficiency Anemia|Vaccine Response Impaired|COVID-19 Vaccine|Iron Deficiency Anemia Treatment
Interventions: DIETARY_SUPPLEMENT: Ferinject
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Fecal Incontinence and Constipation in Patients With Spinal Cord Injury
Status: COMPLETED
Conditions: Constipation|Fecal Incontinence|Spinal Cord Injury
Interventions: PROCEDURE: Transanal irrigation with Peristeen Anal Irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biodentine Versus White MTA Pulpotomy
Status: COMPLETED
Conditions: Extensive Decay in Primary Molars
Interventions: DRUG: Biodentine pulpotomy|DRUG: White MTA pulpotomy|DRUG: Tempophore pulpotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of High Spinal Anesthesia on Heart Function, Stress Response and Pain Control in Aortic Valve Surgery
Status: COMPLETED
Conditions: Aortic Stenosis
Interventions: PROCEDURE: High Spinal and General Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: COMPARISON OF TRANSVERSUS ABDOMINIS PLANE BLOCK, LOCAL ANESTHETIC INJECTION TO THE PORT SITES AND INTRAPERITONEAL LOCAL ANESTHESIA APPLICATIONS IN POSTOPERATIVE PAIN MANAGEMENT IN PATIENTS WITH LAPAROSCOPIC APPENDECTOMY
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Black Cohosh in Treating Hot Flashes in Women Who Have or Who Are At Risk of Developing Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Hot Flashes
Interventions: DIETARY_SUPPLEMENT: black cohosh|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I Study of OCV-501 in Acute Myeloid Leukemia Patients
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: OCV-501|DRUG: OCV-501|DRUG: OCV-501
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies
Status: RECRUITING
Conditions: Congenital Fibrosis of Extraocular Muscles|Duane Retraction Syndrome|Duane Radial Ray Syndrome|Mobius Syndrome|Brown Syndrome|Marcus Gunn Syndrome|Strabismus Congenital|Horizontal Gaze Palsy|Horizontal Gaze Palsy With Progressive Scoliosis|Facial Palsy|Facial Paresis, Hereditary, Congenital|Third Nerve Palsy|Fourth Nerve Palsy|Sixth Nerve Palsy|Synkinesis|Ocular Motility Disorders|Levator-Medial Rectus Synkinesis|Athabaskan Brainstem Dysgenesis|Tongue Paralysis|Ninth Nerve Disorder|Fifth Nerve Palsy|Seventh Nerve Palsy|Eleventh Nerve Disorder|Twelfth Nerve Disorder|Vagus Nerve Paralysis|Moebius Sequence
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Compare the Safety and Pharmacokinetic Characteristics of LBEC0101 25mg With Those of Enbrel®
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LBEC0101 (Etanercept 25mg)|DRUG: Enbrel (Etanercept 25mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Zenith(R) Connection Endovascular Covered Stent Clinical Study
Status: TERMINATED
Conditions: Aorto-iliac Aneurysms|Iliac Aneurysms
Interventions: DEVICE: Zenith(R) Connection Endovascular Covered Stent with the Zenith® Branch Endovascular Graft-Iliac Bifurcation and Zenith Flex(R) AAA Endovascular Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pirfenidone Plus M-DDO Gel in Moderate and Severe Acne
Status: COMPLETED
Conditions: Acne Vulgaris Superficial Mixed Comedonal and Inflammatory
Interventions: COMBINATION_PRODUCT: PDF+M-DDO|COMBINATION_PRODUCT: A+PBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Olaparib Treatment in Relapsed Germline Breast Cancer Susceptibility Gene (BRCA) Mutated Ovarian Cancer Patients Who Have Progressed at Least 6 Months After Last Platinum Treatment and Have Received at Least 2 Prior Platinum Treatments
Status: COMPLETED
Conditions: Relapsed Ovarian Cancer, BRCA Mutation, Platinum Sensitivity
Interventions: DRUG: OLAPARIB|DRUG: Single agent chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess How the Body Processes a Strong Painkiller When it is Given Alongside a Drug That Counteracts the Side Effects of Strong Painkillers in a Fasted and Fed State.
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: 4 mg 12 hourly capsule - strong pain killer fasted|DRUG: 4 mg 12 hourly capsule - strong pain killer fed|DRUG: 12 hourly capsule strong painkiller with antagonist fasted)|DRUG: 4 mg 12 hourly capsule strong painkiller with antagonist fed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: HDUPE 2004: Gastro-Oesophageal Haemorrhage in Emergency : Gastric Préparation to Endoscopy
Status: COMPLETED
Conditions: Upper Gastrointestinal Bleeding
Interventions: DRUG: erythomycin|PROCEDURE: gastric lavage alone|PROCEDURE: erythromycine and gastric lavage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Detecting Tissue Ischemia in Reconstruction Flaps by a Novel CO2 Biosensor (DIMENSION-study)
Status: RECRUITING
Conditions: Ischemia|Blood Circulation Disorder|Biosensing Techniques|Surgery
Interventions: DEVICE: IscAlert
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Smart Box With OT Equator Attachment in Retaining Implant-assisted Overdenture for the Atrophic Maxilla.
Status: COMPLETED
Conditions: Atrophic Maxilla|Edentulous Jaw
Interventions: OTHER: Implant assisted maxillary overdenture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical End Point Study of Generic Adapalene and Benzoyl Peroxide Gel Versus Epiduo® Forte Gel in Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne
Interventions: DRUG: Epiduo® Forte Gel|DRUG: Adapalene and Benzoyl Peroxide Gel|DRUG: placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Deproteinization as a Coadjuvant in Dentin Adhesion of Noncarious Cervical Lesions
Status: UNKNOWN
Conditions: Non-carious Cervical Lesions
Interventions: PROCEDURE: Sodium hypochlorite|PROCEDURE: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Pressure and Flow Measurements to Guide Treatment of Coronary Stenoses
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: OTHER: Percutaneous coronary intervention (PCI)|OTHER: Optimal medical therapy (OMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Varenicline in Methadone-Stabilized Cocaine Users
Status: COMPLETED
Conditions: Cocaine Dependence|Nicotine Dependence
Interventions: DRUG: Varenicline|DRUG: Sugar pill or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: EEG and Behavioral Correlates of Temporal Prediction in the Tactile Modality in Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Tactile stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cast Versus Splint in Children With Acceptably Angulated Wrist Fractures
Status: COMPLETED
Conditions: Distal Radius Fractures
Interventions: DEVICE: Fiberglass short arm cast|DEVICE: Prefabricated wrist splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RSA of the ATTUNE Knee System: RCT Comparing Traditional Vs Enhanced-Fixation Device Designs
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: ATTUNE PS Knee|DEVICE: ATTUNE S+ PS Knee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Whole-grape Powder on Body Composition, Fat and Bone Serum Biomarkers in Postmenopausal Women
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Freeze-dried whole-grape powder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Prospective Comparative Study of Outcomes With Proton and Photon Radiation in Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: Standard of Care IMRT (Photon)|RADIATION: Standard of Care Proton Therapy|RADIATION: Proton Arm 1: Standard Proton Therapy|RADIATION: Proton Arm 2: Hypofractionated Proton Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyaluronic Acid for Hypofractionated Prostate Radiotherapy
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DEVICE: Hyaluronic acid (Macrolane VRF 30®, Q-MED)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arthroscopic Rotator Cuff Tear Repair: Single Versus Double Layer Fixation
Status: UNKNOWN
Conditions: Rotator Cuff Tear
Interventions: PROCEDURE: double layer fixation|PROCEDURE: single layer fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Sleeve Gastroplasty (ESG) for the Treatment of Obesity
Status: RECRUITING
Conditions: Endoscopic Sleeve Gastroplasty|Obesity
Interventions: PROCEDURE: Endoscopic Sleeve Gastroplasty (ESG)|DEVICE: Apollo OverStitch endoscopic suturing device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib in Treating Patients With Metastatic Kidney Cancer That Has Not Responded to Sunitinib or Bevacizumab
Status: COMPLETED
Conditions: Kidney Cancer
Interventions: DRUG: sorafenib tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Islet Transplantation Alone (ITA) in Patients With Difficult to Control Type I Diabetes Mellitus Using a Glucocorticoid-free Immunosuppressive Regimen
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus
Interventions: PROCEDURE: Islet Transplantation + Immunosuppression|BIOLOGICAL: Islet cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Solve Together: A Data Collection Platform for the Collection of Patient and Control Health Information to Support Future Research That Will Accelerate Understanding of the Causes of and Possible Treatments for ME/CFS and Other Chronic Diseases, Including Post-viral Illnesses
Status: RECRUITING
Conditions: Post-Acute COVID-19 Syndrome|ME/CFS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Switch Maintenance Pembrolizumab in Patients With NSCLC After First Line Platinum Doublet Chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Non Small Cell Lung Cancer
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 2 Diabetes on Non-insulin Antidiabetic Therapy
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: HOE901-U300 (new formulation of insulin glargine)|DRUG: Lantus (insulin glargine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: rTMS to Improve Motor Function in Autism
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Motor Activity
Interventions: DEVICE: Active rTMS to the motor cortex|DEVICE: Sham rTMS to the motor cortex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chlorhexidine Disk for Prevention of Exit-site Infection in Peritoneal Dialysis Patients
Status: COMPLETED
Conditions: Peritoneal Dialysis Catheter Exit Site Infection
Interventions: DEVICE: Chlorhexidine-impregnated disk
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION