pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: C-Trelin Orally Disintegrated(OD) Tablet 5mg in Ataxia Due to Spinocerebellar Degeneration
Status: COMPLETED
Conditions: Spinocerebellar Degeneration
Interventions: DRUG: C-Trelin OD Tab(5mg Taltirelin Hydrate)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PROVIT The Influence of Probiotics on Body and Mind in Individuals With Psychiatric Disorders
Status: UNKNOWN
Conditions: Mood Disorders|Depression
Interventions: DIETARY_SUPPLEMENT: Probiotics and vitamin B7|DIETARY_SUPPLEMENT: Placebo and vitamin B7
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Immunogenicity and Safety of Pandemic Influenza Vaccines in Adults Aged 18 - 49 Years Old
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: GSK Biologicals' investigational vaccine GSK2590066A|BIOLOGICAL: GSK Biologicals' investigational vaccine GSK2592984A|BIOLOGICAL: GSK Biologicals' investigational vaccine GSK2340274A|BIOLOGICAL: GSK Biologicals' investigational vaccine GSK2340273A|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fluorescence Imaging With Indocyanine Green(ICG) in Endoscopic Spinal Surgery
Status: RECRUITING
Conditions: Disc Herniation
Interventions: DRUG: Indocyanine Green|DEVICE: Fluorescence imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of BR Alone Versus in Combination With Acalabrutinib in Subjects With Previously Untreated MCL
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma, Mantle Cell
Interventions: DRUG: Acalabrutinib|DRUG: Bendamustine|DRUG: Rituximab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Misoprostol for Preventing Postpartum Hemorrhage
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: misoprostol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II Trial of Pentostatin and Targeted Busulfan
Status: COMPLETED
Conditions: Hematologic Malignancies
Interventions: DRUG: Pentostatin|DRUG: Busulfan|DRUG: Rituximab|PROCEDURE: Allogeneic Hematopoietic Cell Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coronary Microvascular Dysfunction in Angina Patients With Non-obstructive Coronary Artery Disease (ANOCA-CMD)
Status: RECRUITING
Conditions: Angina Patients With Non-obstructive Coronary Artery Disease|Coronary Microvascular Dysfunction|Index of Microvascular Resistance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of Nitric Oxide for Inhalation During Left Ventricular Assists Device (LVAD) Implantation
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: DRUG: Nitric Oxide|DRUG: Nitrogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Interest of the Buccal Schirmer Test in Xerostomia During Sjögren's Syndrome: XERODIAG
Status: NOT_YET_RECRUITING
Conditions: Sjogren's Syndrome|Xerostomia|Diagnosis
Interventions: DIAGNOSTIC_TEST: Buccal Schirmer Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Weight Loss Interventions for Black Adults of Faith
Status: COMPLETED
Conditions: Obesity-Related Malignant Neoplasm
Interventions: BEHAVIORAL: Lifestyle Therapy|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|OTHER: Short-Term Fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Myorelaxant Effect of Cannabis Cream Topical Skin Application in Patients With TMD
Status: COMPLETED
Conditions: Temporomandibular Disorder|Myofascial Pain|Cannabis|Electromyography
Interventions: COMBINATION_PRODUCT: Cannabis Cream|COMBINATION_PRODUCT: Placebo Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study to Collect Information on How Well the Study Drug Naproxen Sodium Tablets Works Compared to Hydrocodone/Acetaminophen Tablets in Order to Relieve Pain in Participants Experiencing Moderate to Severe Pain After Having Their Wisdom Teeth Removed
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Naproxen Sodium (Aleve, BAY117031)|DRUG: Hydrocodone/Acetaminophen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Peppermint Flavored Mouthwash Applied to Patients
Status: NOT_YET_RECRUITING
Conditions: Postoperative Complications
Interventions: OTHER: peppermint flavored mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ingrown Toenails : Surgery Only Versus Surgery + Chemical Cauterization With TCA
Status: UNKNOWN
Conditions: Relapse|Quality of Life|Complication|Pain, Postoperative
Interventions: PROCEDURE: Ingrown toenails with surgery with chemical cauterisation|PROCEDURE: Ingrown toenails with only surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Method for Mydriasis in Cataract Surgery
Status: TERMINATED
Conditions: Cataract
Interventions: DRUG: Topical phenylephrine 2.5%|DRUG: Topical cyclopentolate 1%|DRUG: Intracameral Lidocaine 1%|DRUG: Intracameral 0.2- 0.3ml of epinephrine 1:10,000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neuromodulation of Motion Illusions (Vection)
Status: UNKNOWN
Conditions: Healthy
Interventions: DEVICE: non-invasive neuromodulation|DEVICE: electroencephalography|DEVICE: anatomical MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of the "Living With Type 1 Diabetes to Grown-Up" Interactive Podcast Program
Status: RECRUITING
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: Online Interactive Podcast Program "Living with Type 1 Diabetes to Grown-Up"|DEVICE: E-book
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Emergency Department Bedside Compression Ultrasonography on Door-to-Disposition Time in Patients Suspicious for Lower Extremity Deep Venous Thrombosis
Status: COMPLETED
Conditions: Lower Extremity Deep Vein Thrombosis
Interventions: DIAGNOSTIC_TEST: Bedside Compression Ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: BestBrain Evaluation of Cognitive Memory & Executive-Function
Status: UNKNOWN
Conditions: Mild Cognitive Impairment
Interventions: DEVICE: iRemember Neurofeedback (NFB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BNCT to Treat Glioma That Has Progressed Following Radiotherapy
Status: COMPLETED
Conditions: Glioblastoma|Anaplastic Astrocytoma
Interventions: RADIATION: Bononophenylalanine (BPA)-based BNCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of The PF-04958242 Blood Concentrations Of A Capsule Formulation Of PF-04958242 Compared To A Solution Formulation
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-04958242 capsule|DRUG: PF-04958242 oral solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Support Through Remote Observation and Nutrition Guidance (STRONG) Program for Gastroesophageal Cancer (GEC) Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: GastroEsophageal Cancer
Interventions: BEHAVIORAL: Fitbit Data Collection|BEHAVIORAL: Nutrition Counseling|BEHAVIORAL: Survey
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Relative Bioavailability For Palbociclib Formulations
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Palbociclib Formulation Reference|DRUG: Palbociclib Formulation Test|DRUG: Palbociclib Formulation Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: First-in-Human Study of XMT-1592 in Patients With Ovarian Cancer and NSCLC Likely to Express NaPi2b
Status: TERMINATED
Conditions: Ovarian Cancer|Nonsmall Cell Lung Cancer
Interventions: BIOLOGICAL: XMT-1592
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploration of Mesocorticolimbic Pathway in Impulse Control Disorders in Parkinson's Disease: Study Using Tensor Diffusion Imaging and Tractography.
Status: UNKNOWN
Conditions: Parkinson's Disease|Impulse Control Disorders
Interventions: DEVICE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Azacitidine, Cytarabine, and Mitoxantrone Hydrochloride in Treating Patients With High-Risk Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Recurrent Adult Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: azacitidine|DRUG: cytarabine|DRUG: mitoxantrone hydrochloride|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Equivalency Study of Two Formulations of Mometasone Furoate Nasal Spray (Study P04419)
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial
Interventions: DRUG: mometasone furoate|DRUG: mometasone furoate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ComparisiOn of Neointimal coVerage betwEen ZES and EES Using OCT at 3 Months
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: ZES resolute (Endeavor Resolute)|DEVICE: EES (Xience)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protection From Pulmonary Embolism With the Permanent OptEase™ Filter (PROOF)
Status: COMPLETED
Conditions: Pulmonary Embolism
Interventions: DEVICE: OPTEASE Vena Cava Filter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Pectoralis Minor Muscle Stretching Protocol
Status: COMPLETED
Conditions: Shoulder Pain
Interventions: PROCEDURE: Stretching-Asymptomatic subjects|PROCEDURE: Stretching-Subjects with shoulder pain
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects and Safety of Clonidine Patch on Young and Middle-aged Smokers With Mild Hypertension
Status: NOT_YET_RECRUITING
Conditions: Hypertension
Interventions: DRUG: Clonidine controlled-release patch|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Examination How the Administration Period of Teriparatide Affects Bone Metabolism and Bone Mineral Density Prior to Denosumab Therapy
Status: RECRUITING
Conditions: Osteoporosis
Interventions: DRUG: "Teriparatide", "Forteo® or Teribon"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Filanesib and Carfilzomib in Treating Patients With Relapsed or Refractory Multiple Myeloma or Plasma Cell Leukemia
Status: COMPLETED
Conditions: Plasma Cell Leukemia|Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: DRUG: Carfilzomib|DRUG: Filanesib|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigational Immunotherapy Study of BMS-986258 Alone and in Combination With Nivolumab in Participants With Solid Cancers That Are Advanced or Have Spread
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Cancer
Interventions: BIOLOGICAL: BMS-986258|BIOLOGICAL: Nivolumab|DRUG: rHuPH20
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Imaging Study in Menopausal Women With and Without Major Depressive Disorder
Status: COMPLETED
Conditions: Menopause|Depression
Interventions: DRUG: MDD diagnosis and Estrogen treatment|DRUG: MDD diagnosis and Fluoxetine treatment|DRUG: MDD diagnosis with both Estrogen and Fluoxetine treatment|DRUG: No depression and estrogen treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NIVATS Versus IGAVATS: a Pilot Trial Addressing Biopsy Quality in Undetermined Interstitial Lung Diseases
Status: RECRUITING
Conditions: Lung Diseases, Interstitial
Interventions: PROCEDURE: Non-intubated video-assisted thoracic surgery (NIVATS) for lung biopsy|PROCEDURE: Intubated general anaesthesia video-assisted thoracic surgery (IGAVATS) for lung biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluating Nimotuzumab in Combination With AG Regimen for Pancreatic Cancer With Liver Metastases : A Prospective, Single-Arm, Phase II Study
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: nimotuzumab|DRUG: AG chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability Study of Solifenacin Succinate Liquid Suspension (Fed and Fasting) Versus VESIcare Tablet (Fasting) in Healthy Volunteers
Status: COMPLETED
Conditions: Bioavailability of Solifenacin Succinate|Pharmacokinetics of Solifenacin Succinate|Healthy Volunteers
Interventions: DRUG: solifenacin succinate suspension|DRUG: solifenacin succinate tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Modeling Genotype and Other Factors to Enhance the Safety of Coumadin Prescribing
Status: UNKNOWN
Conditions: Atrial Fibrillation|Deep Venous Thrombosis|Heart Valve Replacement|Pulmonary Embolism
Interventions: DRUG: Coumadin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Intraventricular Hemorrhage and Post Hemorrhagic Ventricular Dilation: Natural Course, Treatment, and Outcome
Status: COMPLETED
Conditions: Intraventricular Hemorrhage|Premature Infants
Interventions: PROCEDURE: NIRS, aEEG, and CSF concentration of biomarkers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Chemo-Gut Probiotic Trial for Cancer Survivors
Status: NOT_YET_RECRUITING
Conditions: Cancer|Psychosocial Problem|Gastrointestinal Dysfunction
Interventions: DIETARY_SUPPLEMENT: Multistrain Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Explore Neuroprotective Effect of Lipoic Acid in Amyotrophic Lateral Sclerosis
Status: UNKNOWN
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: lipoic acid group|DRUG: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biological Therapy in Treating Patients With Metastatic Melanoma or Metastatic Kidney Cancer
Status: COMPLETED
Conditions: Kidney Cancer|Melanoma (Skin)
Interventions: BIOLOGICAL: recombinant CD40-ligand|BIOLOGICAL: recombinant flt3 ligand
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Sildenafil in Acute Pulmonary Embolism
Status: COMPLETED
Conditions: Pulmonary Embolism
Interventions: DRUG: Sildenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Acute Effects of Passive Vibration on Cardiovascular Function in Individuals With Stroke
Status: COMPLETED
Conditions: Stroke|Hemiparesis|Pre-Hypertension|Hypertension
Interventions: OTHER: Low-Frequency Passive Vibration|OTHER: High-Frequency Pasive Vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dose Escalation and Dose Expansion Study of IPN60090 in Patients With Advanced Solid Tumours
Status: TERMINATED
Conditions: Solid Tumor
Interventions: DRUG: IPN60090|DRUG: pembrolizumab|DRUG: paclitaxel|DRUG: IPN60090 single administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vemurafenib in Combination With Everolimus or Temsirolimus With Advanced Cancer
Status: COMPLETED
Conditions: Advanced Cancer|Solid Tumor
Interventions: DRUG: Vemurafenib|DRUG: Everolimus|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sirolimus in COVID-19 Phase 1
Status: WITHDRAWN
Conditions: SARS-CoV-2|Covid-19
Interventions: DRUG: Sirolimus 1 MG/ML|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Allulose on Diet-induced Thermogenesis
Status: RECRUITING
Conditions: Diet Induced Thermogenesis
Interventions: OTHER: Allulose Dose 1|OTHER: Allulose Dose 2|OTHER: Allulose Dose 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Outpatient Office Based Endovascular Procedures
Status: ENROLLING_BY_INVITATION
Conditions: Chronic Venous Insufficiency|Peripheral Arterial Disease|Dialysis Access Malfunction|Arterio-venous Fistula|Thoracic Outlet Syndrome|Vertebral Artery Insufficiency|Varicose Veins
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of Cannabidiol (CBD) on Electrical and Autonomic Cardiac Function in Children With Severe Epilepsy
Status: TERMINATED
Conditions: Lennox-Gastaut Syndrome|Dravet Syndrome
Interventions: PROCEDURE: 12-Lead ECG|DRUG: Cannabidiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of SEL-212 in Patients With Gout Refractory to Conventional Therapy II
Status: COMPLETED
Conditions: Chronic Gout
Interventions: DRUG: SEL-212 low-dose|DRUG: SEL-212 high-dose|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Group Cognitive Behavioral Therapy to Treat Depression in an Epilepsy Clinic Setting
Status: COMPLETED
Conditions: Epilepsy|Depressive Disorder
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy (CBT) in a Group Format
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sarcopenia and Nutritional Status in a Rehabilitation Setting
Status: RECRUITING
Conditions: Sarcopenia
Interventions: DIAGNOSTIC_TEST: handgrip strenght|DIAGNOSTIC_TEST: Bioelectrical Impedance Analysis (BIA)|DIAGNOSTIC_TEST: MUST|DIAGNOSTIC_TEST: GLIM|BIOLOGICAL: Gut microbiota|BIOLOGICAL: Blood Sample|OTHER: Anthropometric measures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prospective Evaluation of NOTES (Natural Orifice Translumenal Endoscopic Surgery) PEG "Rescue"
Status: TERMINATED
Conditions: Malnutrition
Interventions: PROCEDURE: Natural Orifice Translumenal Endoscopic Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term of Remote Ischemic Preconditioning in Patients With Mild Hypertension
Status: UNKNOWN
Conditions: Hypertension
Interventions: OTHER: Antihypertensive drugs|OTHER: remote ischemic preconditioning（RIPC）|BEHAVIORAL: lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Suboptimal CPAP Therapy on Symptoms of Obstructive Sleep Apnoea
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DEVICE: Continous Positive Air Pressure Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Social Media Chatbot on Physical Activity Education for Older Adults
Status: NOT_YET_RECRUITING
Conditions: Exercise|Self Efficacy|Behavioral Regulation|Healthy Aging
Interventions: OTHER: Social Media Chatbot on Physical Activity Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Multimodal Opioid-free Anesthesia Versus Opioid-based Anesthesia for Patients Undergoing Cardiac Valve Surgeries: RCT
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Dexmedetomidine 0.5 mic/kg/h|DRUG: Fentanyl 1 mic/kg/hr
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Liraglutide in Combination With Insulin Therapy Compared to Insulin Alone in Japanese Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: placebo|DRUG: insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Retinoid 9cUAB30 in Producing a Biologic Effect in Patients With Early Stage Breast Cancer
Status: TERMINATED
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Breast Ductal Carcinoma In Situ|Early Stage Breast Carcinoma|Invasive Breast Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Retinoid 9cUAB30|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: TAHOE: Intravitreal Dexamethasone Implant (Ozurdex) for Uveitic Macular Edema
Status: COMPLETED
Conditions: Macular Edema|Uveitis
Interventions: DRUG: Ozurdex Intravitreal Injection (0.7 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Statin Therapy In Atrial Refractoriness and Reperfusion Injury
Status: COMPLETED
Conditions: Disorder; Heart, Functional, Postoperative, Cardiac Surgery|Cardiac Insufficiency Following Cardiac Surgery|Atrial Fibrillation|Ischaemia-reperfusion Injury
Interventions: DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Coach-Guided Online Acceptance and Commitment Therapy (ACT) Intervention for Stroke Survivors
Status: WITHDRAWN
Conditions: Depression|Anxiety|Stress|Stroke
Interventions: BEHAVIORAL: acceptance and commitment therapy (ACT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clofarabine in Adult Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors|Leukemia, Lymphocytic, Acute, Pediatric|Leukemia, Lymphocytic, Acute, Adult|Leukemia, Myelocytic, Acute, Pediatric|Leukemia, Myelocytic, Acute, Adult|Myelodysplastic Syndromes, Adult
Interventions: DRUG: clofarabine (IV formulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Trial of Automated Risk Appraisal for Adolescents
Status: COMPLETED
Conditions: Substance Use|Depression|Suicidal Ideation|Risk Behavior
Interventions: BEHAVIORAL: Telephone case management and motivational interviewing|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Characterization of Bovine Adrenal Medulla (BAM8-22) as a New Surrogate Model of Non-histaminergic Itch
Status: UNKNOWN
Conditions: Itch
Interventions: DRUG: BAM8-22 2mg/ml|DRUG: BAM8-22 1mg/ml|DRUG: BAM8-22 0.5 mg/ml|DRUG: Placebo|DRUG: BAM8-22 with 1 SPT|DRUG: BAM8-22 with 5 SPT|DRUG: BAM8-22 with 25 SPT|DRUG: BAM8-22 with inactivate cowhage spicules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety/Feasibility Study of HBOC-201 in Amputation at/Below Knee From Critical Lower Limb Ischemia
Status: TERMINATED
Conditions: Peripheral Vascular Disease
Interventions: DRUG: Hemoglobin glutamer 250 - bovine|DRUG: 6% Hydroxyethylstarch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Placebo-controlled, Single and Multiple Dose Study in Healthy Volunteers and Refractory Chronic Cough Patients to Assess the Safety, Tolerability, and Pharmacokinetics of Two Formulations of NTX-1175
Status: COMPLETED
Conditions: Refractory Chronic Cough
Interventions: DRUG: 3 mg NOC-100 (via nebulizer)|DRUG: 1 mg NOC-110 (via DPI) [1x 1 mg capsule]|DRUG: 3 mg NOC-110 (via DPI)|DRUG: Placebo (via DPI)|DRUG: 6 mg NOC-110 (via DPI)|DRUG: Placebo (via DPI) [2x Placebo capsules]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging the Effects of Stimulant Medication on Emotional Lability in Patients With ADHD
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Lisdexamfetamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COVIDISC: Rapid Diagnostic Tests on Nasopharyngeal Swabs for the Detection of COVID-19
Status: TERMINATED
Conditions: COVID-19|SARS-CoV-2
Interventions: DIAGNOSTIC_TEST: Rapid Diagnostic Test vs PCR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: S-amlodipine+Chlorthalidone vs S-amlodipine+Telmisartan in Hypertension
Status: UNKNOWN
Conditions: Essential Hypertension
Interventions: DRUG: S-amlodipine 2.5mg + Chlorthalidone 25mg|DRUG: S-amlodipine 2.5mg + Telmisartan 40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CM326 in Subjects With Moderate to Severe Asthma
Status: RECRUITING
Conditions: Moderate to Severe Asthma
Interventions: DRUG: CM326|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Retrospective Study of the Efficacy and Safety of Lolatinib in ALK+ NSCLC Patients With Brain or Meningeal Metastasis
Status: ACTIVE_NOT_RECRUITING
Conditions: ALK-positive Non-small Cell Lung Cancer|Brain Metastases|Meningeal Metastasis
Interventions: DRUG: Lorlatinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Correlation of Nasal Volume, Cross-Sectional Area With Nasalance Scores Measured by Acoustic Rhinometry and Nasometry
Status: TERMINATED
Conditions: Allergy
Interventions: PROCEDURE: Acoustic rhinometry (procedure)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Tolerability, and Immunogenicity of V110 or V114 Co-administered With a Booster Dose of mRNA-1273 in Healthy Adults (V110-911)
Status: COMPLETED
Conditions: Pneumococcal Infection
Interventions: BIOLOGICAL: V110|BIOLOGICAL: V114|BIOLOGICAL: mRNA-1273|BIOLOGICAL: Placebo for V110|BIOLOGICAL: Placebo for V114
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Sitagliptin and Metformin Hydrochloride Tablets 50 mg/1000 mg Relative to Originator
Status: NOT_YET_RECRUITING
Conditions: Healthy Subjects
Interventions: DRUG: Sitagliptin and Metformin Hydrochloride Tablets Test product|DRUG: Sitagliptin and Metformin Hydrochloride Tablets Reference product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: 68-Ga-FAPI PET Imaging in Malignancy
Status: WITHDRAWN
Conditions: Cancer
Interventions: DRUG: 68Ga-FAPI|PROCEDURE: Computed Tomography (CT) scan|PROCEDURE: Positron Emission Tomography (PET) scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Brigatinib in Participants With Anaplastic Lymphoma Kinase-Positive (ALK+), Advanced Non-Small-Cell Lung Cancer (NSCLC) Progressed on Alectinib or Ceritinib
Status: ACTIVE_NOT_RECRUITING
Conditions: ALK-positive Advanced NSCLC
Interventions: DRUG: Brigatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Metformin and Probiotics in Reproductive-aged Patients With Polycystic Ovary Syndrome
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Metformin tablets|DRUG: ProMetS probiotics powder|DRUG: 1. Metformin tablets; 2. ProMetS probiotics powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Wheat Dextrin on Calcium and Magnesium Absorption
Status: COMPLETED
Conditions: Colonic Inertia
Interventions: DIETARY_SUPPLEMENT: wheat dextrin|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarker Study Accompanying the AIO-TRK-0114 Study (MARBLE)
Status: TERMINATED
Conditions: Non-small-cell Lung Cancer With Somatic EGFR Mutations
Interventions: DRUG: Afatinib|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug Interaction Study to Evaluate the Pharmacokinetics of ASP1517 and Lanthanum Carbonate Hydrate
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: ASP1517|DRUG: Lanthanum carbonate hydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Melphalan in People With Lymphoma Getting an Autologous Hematopoietic Cell Transplant
Status: RECRUITING
Conditions: Lymphoma|Lymphoma, B-Cell|Lymphoma, T-Cell|Lymphoma, Hodgkin|Lymphoma, Non-Hodgkin
Interventions: OTHER: Pharmacokinetics|OTHER: Pharmacokinetics
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Evaluation of Absorb™ Bioresorbable Vascular Scaffold (Absorb™ BVS) System in Chinese Population ~ ABSORB CHINA Randomized Controlled Trial (RCT)
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Artery Stenosis|Coronary Disease|Coronary Stenosis
Interventions: DEVICE: XIENCE V EECSS|DEVICE: Absorb BVS System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Relative Efficacy of Vitamins D2 and D3 in Adult Humans
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: vitamin D2|DIETARY_SUPPLEMENT: vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Outcomes and Safety Trial Investigating Ecallantide's Effect on Reducing Surgical Blood Loss Volume in Subjects at High Risk of Bleeding Exposed to Cardio-pulmonary Bypass During Cardiac Surgery
Status: COMPLETED
Conditions: Bloodloss|Surgical Procedures, Operative
Interventions: DRUG: Ecallantide|DRUG: Cyklokapron(R)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Tegaderm-CHG® Dressing vs. Tegaderm-IV® Dressing
Status: UNKNOWN
Conditions: Intravascular Catheter Colonization
Interventions: DEVICE: Application of a dressing with clorhexidine gluconate in intravascular catheters.|DEVICE: Application of a dressing without clorhexidine gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Tadalafil vs. Tadalafil With Sildosin in the Management of Moderately and Severely Symptomatic Patients of Prostatic Hyperplasia
Status: UNKNOWN
Conditions: Safety and Efficacy of Tadalafil vs. Tadalafil With Sildosin in the Management of Moderately and Severely Symptomatic Patients of Prostatic Hyperplasia
Interventions: DRUG: Tadalafil 5mg
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Triple Combination Therapy in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma, Open-Angle|Ocular Hypertension
Interventions: DRUG: bimatoprost/brimonidine tartrate/timolol ophthalmic solution (Triple Combination Therapy)|DRUG: Fixed Combination 0.2% brimonidine tartrate/0.5% timolol ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness-Based Cognitive Therapy + Safety Planning For Suicidal Behavior
Status: COMPLETED
Conditions: Monopolar Depression, Single Episode or Unspecified|Suicidal and Self-injurious Behaviour
Interventions: BEHAVIORAL: MBCT+SPI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Exercise Versus Rosiglitazone in CAD and Prediabetes
Status: COMPLETED
Conditions: Impaired Glucose Tolerance
Interventions: DRUG: rosiglitazone|BEHAVIORAL: physical exercise|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of BM-MSCs on Chronic AMR After Kidney Transplantation
Status: UNKNOWN
Conditions: Kidney Transplantation
Interventions: OTHER: BM-MSCs|OTHER: Desensitization therapy (PP, IVIG, rituximab or Bortezomib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of AIN457 in Moderate to Severe Active Crohn's Disease
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: DRUG: AIN457|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Multicenter Evaluation of a New Short-access-cholangioscope for Biliary Duct Strictures and Gall Stones
Status: COMPLETED
Conditions: Choledocholithiasis|Common Bile Duct Neoplasms|Cholestasis
Interventions: DEVICE: cholangioscopy (Frimberger)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polyphenol Supplementation and Morbid Obesity Parameters
Status: COMPLETED
Conditions: Morbid Obesity
Interventions: DIETARY_SUPPLEMENT: Polyphenol-rich supplement|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Timing of Parasternal Intercostal Nerve Block Application for Acute Pain Management in Cardiac Surgery
Status: COMPLETED
Conditions: Pain, Acute
Interventions: PROCEDURE: pre-incisional parasternal intercostal block|PROCEDURE: post-incisional parasternal intercostal block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pembrolizumab and Lenvatinib/Chemotherapy for Poorly Differentiated/Anaplastic Thyroid Cancer
Status: WITHDRAWN
Conditions: Metastatic Thyroid Gland Carcinoma|Poorly Differentiated Thyroid Gland Carcinoma|Thyroid Gland Anaplastic Carcinoma by AJCC V8 Stage
Interventions: DRUG: Lenvatinib|BIOLOGICAL: Pembrolizumab|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glass Ionomer Sealant and Fluoride Varnish Study to Prevent Early Childhood Caries
Status: COMPLETED
Conditions: Dental Caries
Interventions: DEVICE: Fluoride Varnish|DEVICE: Glass Ionomer Sealant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Plyometric Training Versus Virtual Reality Among Hemiplegic Cerebral Palsy
Status: RECRUITING
Conditions: Hemiplegic Cerebral Palsy
Interventions: DEVICE: Virtual Reality|DEVICE: Plyometric Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Multiple Intravenous Dose Study to Examine Safety, Tolerability, and PK of Intravenous TD-8954, a 5-HT4 Receptor Agonist, in Healthy Subjects
Status: TERMINATED
Conditions: Gastrointestinal Motility Disorder
Interventions: DRUG: TD-8954|DRUG: Placebo - saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of the Efficacy and Safety of Alirocumab (REGN727/SAR236553) in Combination With Other Lipid-modifying Treatment (LMT) (ODYSSEY OPTIONS I)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Alirocumab|DRUG: Atorvastatin|DRUG: Ezetimibe|DRUG: Rosuvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Effect of Food, Safety and Tolerability of a New Tablet Formulation of GSK1144814 in Healthy Subjects
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: GSK1144814
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Efficacy of a Dyslipidemic Therapy in Mexican Population
Status: UNKNOWN
Conditions: Dyslipidemias|Cardiovascular Risk Factor
Interventions: DRUG: L-Carnitine 500Mg Oral Tablet + Atorvastatin 10 mg|DRUG: Atorvastatin 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Two Norepinephrine Rescue Bolus Doses for Management of Severe Post-spinal Hypotension During Elective Cesarean Delivery
Status: COMPLETED
Conditions: Postspinal Hypotension|Cesarean Delivery|Norepinephrine
Interventions: DRUG: Norepinephrine 5 mcg|DRUG: Norepinephrine 10 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study of Direct Access to an Abdominal ´Yes-No´ Pathway for Primary Care Patients
Status: COMPLETED
Conditions: Cancer|Primary Health Care
Interventions: DIAGNOSTIC_TEST: Abdominal ´yes-no´ pathway
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Single Session Of Antimicrobial Photodynamic Therapy Using Indocyanine Green
Status: COMPLETED
Conditions: Periodontitis
Interventions: DRUG: indocyanine green|DEVICE: LASER|PROCEDURE: Scaling and Root Planing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Combined Buprenorphine and Behavioral Treatment With and Without Contingent Reinforcement on Opioid and Cocaine Abstinence. - 22
Status: COMPLETED
Conditions: Cocaine-Related Disorders|Opioid-Related Disorders
Interventions: DRUG: Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Women With Lipedema Involving Substantial Fat Knee of Women and Men With Nodular Dercum's Disease
Status: COMPLETED
Conditions: Lipedema|Dercum Disease
Interventions: DRUG: RZL-012
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GVAX Plus Checkpoint Blockade in Neuroblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Neuroblastoma|Pediatric Solid Tumor
Interventions: PROCEDURE: Tissue collection|BIOLOGICAL: GVAX vaccine|DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interventions to Decrease Financial Toxicity
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer, Breast|Cancer Colorectal|Cancer, Ovarian|Cervical Cancer|Uterine Cancer|Vulvar Cancer
Interventions: OTHER: Proactive Cost of Care (P-COC) intervention|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Medical Herbs Inhibit Inflammation Directing T Cells to Kill the COVID-19 Virus (COVID)
Status: UNKNOWN
Conditions: Covid19 Virus Infection
Interventions: DIETARY_SUPPLEMENT: Inflammation (I)|DIETARY_SUPPLEMENT: Inflammation (II)|DIETARY_SUPPLEMENT: Inflammation (III)|DRUG: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Use of Dermabond Versus Standard Staple for Wound Closure in Children With Neuromuscular Scoliosis Undergoing Spinal Deformity Correction Surgery
Status: UNKNOWN
Conditions: Wounds
Interventions: DEVICE: 2-octylcyanoacrylate (Dermabond) closure|DEVICE: Standard staple closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy of Combination of Pregabalin and Antioxidant in Reducing Pain in Chronic Pancreatitis: a Randomized Control Trial
Status: COMPLETED
Conditions: Chronic Pancreatitis
Interventions: DRUG: Placebo|DRUG: Antioxidant plus Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT