pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Ketofol Versus Propofol for Sedation in Cholangiopancreatography for ASA III and ASA IV Patients.
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Profofol for Sedation in Cholangiopancreatography for ASA III and ASA IV Patients|DRUG: Ketofol for Sedation in Cholangiopancreatography for ASA III and ASA IV Patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Prospective Study Frailty for Esophagectomy and Lung Resection in Thoracic Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Thoracic|Thoracic Neoplasm|Lung Cancer|Esophageal Cancer|Surgery--Complications|Surgery|Sarcopenia|Malnutrition|Frail Elderly Syndrome
Interventions: DIAGNOSTIC_TEST: Frailty model
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multilevel HPV Self-Testing Intervention for the Increase of Cervical Cancer Screening Among Women in Appalachia
Status: RECRUITING
Conditions: Cervical Carcinoma|Human Papillomavirus Infection
Interventions: OTHER: Best Practice|PROCEDURE: HPV Self-Collection|OTHER: Informational Intervention|BEHAVIORAL: Patient Navigation Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Chemotherapy Before Autologous Stem Cell Transplantation +/- Rituximab in Relapsed or Refractory Aggressive Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: cisplatin|DRUG: cytarabine|DRUG: dexamethasone|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication
Status: UNKNOWN
Conditions: Diffuse Intrinsic Pontine Glioma
Interventions: DRUG: Erlotinib|DRUG: Everolimus|DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Perfusion by Iodine Subtraction Mapping CT Angiography in Acute Pulmonary Embolism
Status: COMPLETED
Conditions: Pulmonary Embolism
Interventions: DIAGNOSTIC_TEST: Pulmonary tomoscintigraphy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Non-inferiority Study of the Glucosamine Sulfate + Chondroitin Sulfate Association Capsule in Comparison to the CONDROFLEX® Product in Osteoarthrosis of the Knee
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Glucosamine sulfate + chondroitin sulfate - MANTECORP|DRUG: Glucosamine sulfate + chondroitin sulfate - CONDROFLEX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phenol and Silver Nitrate Application in Pilonidal Sinus
Status: UNKNOWN
Conditions: Pilonidal Sinus of Natal Cleft|Pilonidal Sinus Without Abscess
Interventions: DRUG: Silver Nitrate|DRUG: Phenol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Varenicline and Smoking Cessation in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Smoking Cessation
Interventions: OTHER: Sugar Pill|DRUG: Varenicline|DRUG: Bupropion HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Different Insulin Dose Calculation Algorithms in Type 1 Diabetes
Status: COMPLETED
Conditions: Insulin-Dependent Diabetes Mellitus 1
Interventions: OTHER: High GI calculated by CC (CHGI)|OTHER: Low GI calculated by CC (CLGI)|OTHER: High GI calculated by FII (FHGI)|OTHER: Low GI calculated by FII (FLGI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: A Phase I/II Trial of Tetravalent Live Attenuated Dengue Vaccine in Flavivirus Antibody Naive Infants
Status: COMPLETED
Conditions: Dengue
Interventions: BIOLOGICAL: Tetravalent live attenuated dengue vaccine|BIOLOGICAL: Varicella vaccine and Haemophilus influenzae Type b Conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Natural History of Granulomatosis With Polyangiitis: Clinical and Genetic Biomarkers of Airway Disease NoAAC PR-03 Study
Status: WITHDRAWN
Conditions: Granulomatosis With Polyangiitis
Interventions: PROCEDURE: Airway assessment|PROCEDURE: Rheumatology assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 2a Study of IW-6463 in Adults Diagnosed With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS)
Status: TERMINATED
Conditions: MELAS
Interventions: DRUG: IW-6463 Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-interaction Study of Chlorthalidone and Losartan in Fixed Combination, in Healthy Subjects, Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Chlorthalidone (HIGROTON® 50)|DRUG: Losartan (COZZAR®)|DRUG: A1+ A2 Co-administration of Chlorthalidone and Losartan|DRUG: Chlorthalidone + Losartan Fixed-Dose combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Assessing the Efficacy and Safety of CBP-307 in Subjects With Moderate to Severe Ulcerative Colitis (UC)
Status: COMPLETED
Conditions: Moderate to Severe Ulcerative Colitis
Interventions: DRUG: Double-Blind 0.2mg CBP-307|DRUG: Double-Blind Placebo|DRUG: Open-label CBP-307|DRUG: Double-Blind 0.1mg CBP-307
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remotely Prescribed and Monitored Home-based Gait-and-balance Augmented Reality Exergaming for People With Parkinson's Disease.
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DEVICE: Cue X
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stimulation Test With Intranasal Glucagon for Corticotroph, Somatotroph and Antidiuretic Axes
Status: COMPLETED
Conditions: Hypopituitarism
Interventions: DRUG: Intranasal glugagon|DRUG: Intranasal placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Renin-Angiotensin System Inhibitors Continuation on Outcome After Major Surgery
Status: COMPLETED
Conditions: Renin Angiotensin System|Surgery
Interventions: PROCEDURE: continuation of the RAS-inhibitors|PROCEDURE: discontinuation of the RAS-inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase II Study of Oxaliplatin and Navelbine for Second-Line Treatment of Advanced NSCLC.
Status: UNKNOWN
Conditions: Previously Treated Metastatic Non-Small Cell Lung Cancer
Interventions: DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Isolated Resistance Training and Neuromuscular Electrical Stimulation in Patients With Femoral Intra Aortic Balloon Pump.
Status: RECRUITING
Conditions: Heart Failure|Physical Therapy|Neuromuscular Electrical Stimulation
Interventions: OTHER: Isolated Resistance Training Program|OTHER: Neuromuscular electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy and Safety of a Fixed Combination Ocular Insert in Participants With Open-angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Fixed Combination|DRUG: Bimatoprost|DRUG: Timolol|DEVICE: Placebo Segment|DRUG: Timolol 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Human Amniotic Mesenchymal Cell Secretome for Neurodegeneration and Neuroinflammation
Status: NOT_YET_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis|Multiple Sclerosis
Interventions: OTHER: Venous blood draw and skin biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Post-operative Mobilization for Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: PROCEDURE: Carpal tunnel release surgery|PROCEDURE: Carpal tunnel release surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Two Treatment Regimens of Cocamide DEA Lotion for Head Lice
Status: TERMINATED
Conditions: Pediculosis|Head Louse Infestation
Interventions: DRUG: cocamide diethanolamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cisplatin and S-1 With or Without Nimotuzumab in Untreated Advanced Gastric Adenocarcinoma
Status: COMPLETED
Conditions: Stomach Neoplasms
Interventions: DRUG: nimotuzumab|DRUG: cisplatin|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy Plus QS21 in Treating Patients With Small Cell Lung Cancer That Has Responded to Initial Therapy
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: QS21|BIOLOGICAL: keyhole limpet hemocyanin|DRUG: polysialic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Posterolateral Versus Lateral Internal Anal Sphincterotomy for Chronic Anal Fissure
Status: COMPLETED
Conditions: Anal Fissure
Interventions: PROCEDURE: posterolateral sphincterotomy|PROCEDURE: lateral sphincterotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Effectiveness Study of JNJ-31001074 in Adults With Attention-Deficit/Hyperactivity Disorder.
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Placebo|DRUG: JNJ-31001074|DRUG: JNJ-31001074
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prediction of Progression of Age-Related Macular Degeneration
Status: UNKNOWN
Conditions: Macular Degeneration|Macular Degeneration, Wet|Macular Degeneration, Dry
Interventions: OTHER: Algorithm prediction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Tart Cherry Juice in Reducing Muscle Injury and Biomarkers of Muscle Damage Among Healthy Adults
Status: COMPLETED
Conditions: Inflammation|Pain
Interventions: DIETARY_SUPPLEMENT: tart cultivar Montmorency cherry juice|DIETARY_SUPPLEMENT: placebo cherry fruit drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Role of Adjuvant Proton Beam Therapy in Patients With Parotid Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Parotid Cancer
Interventions: RADIATION: Proton Beam Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Therapeutic Drug Monitoring of Cefazolin in Continuous Renal Replacement Therapy
Status: UNKNOWN
Conditions: Renal Replacement Therapy|Pharmacokinetics
Interventions: DRUG: Cefazolin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: An Effectiveness and Safety Study of IDEA-033 in Comparison to Oral Naproxen and Placebo for the Treatment of Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: IDEA-033
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Micro-Particle Curcumin for the Treatment of Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Micro-particle Curcumin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trastuzumab in Combination With Vinorelbine or Taxane-Based Chemotherapy in Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: Trastuzumab|DRUG: Vinorelbine|DRUG: Paclitaxel|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Bracket Design and Oral Hygiene Maintenance on Halitosis in the Orthodontic Patient
Status: COMPLETED
Conditions: Halitosis|Oral Hygiene
Interventions: OTHER: Tongue scraping|OTHER: Bracket design
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Group Curriculum for Improving Survivorship Outcomes in Adolescent and Young Adult Cancer Survivors
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid System Neoplasm|Malignant Solid Neoplasm
Interventions: OTHER: Counseling|PROCEDURE: Discussion|OTHER: Informational Intervention|OTHER: Medical Chart Review|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Relationship Between Traumatic Brain Injury and Dopamine (a Chemical in the Brain)
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: DRUG: Methylphenidate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Remote Ischemic Preconditioning on the Prognosis of Patients With Elective PCI Using Drug-coated Balloon
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: OTHER: RIPC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Role of AI in CE for the Identification of SB Lesions in Patients With Small Intestinal Bleeding.
Status: COMPLETED
Conditions: Iron Deficiency Anemia|Obscure Gastrointestinal Bleeding
Interventions: DEVICE: Capsule endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mindfulness-Based VR for Family Caregivers of People With Dementia
Status: COMPLETED
Conditions: Caregivers of People With Dementia|Quality of Life
Interventions: BEHAVIORAL: Mindfulness-Based VR|BEHAVIORAL: Audio
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Articaine Infiltration in Anesthetizing Mandibular Second Primary Molars
Status: COMPLETED
Conditions: Anesthesia, Local
Interventions: OTHER: Articaine infiltration technique|OTHER: Articaine nerve block technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The ABSORB Bioresorbable Scaffold Below the Knee (BTK) Study
Status: TERMINATED
Conditions: Ischemia|Peripheral Arterial Disease (PTA|Arterial Occlusive Diseases
Interventions: DEVICE: Absorb Bioresorbable Vascular Scaffold
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measuring Patient-Reported Adverse Events in Oncology Practice Improves Quality of Life in Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Neoplasms
Interventions: OTHER: adverse events using patient-reported outcomes version of common terminology criteria for adverse events (PRO-CTCAE) questionaire|OTHER: do not report adverse events through patient-reported outcomes version of common terminology criteria for adverse events (PRO-CTCAE) questionaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Efficacy and Safety of Ibrutinib, in Patients With Mantle Cell Lymphoma Who Progress After Bortezomib Therapy
Status: COMPLETED
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid-free Analgesia for the Management of Acute Post-operative Pain Following Caesarean Section
Status: COMPLETED
Conditions: Acute Post-operative Pain Following Caesarean Section
Interventions: DRUG: Magnesium sulphate|DRUG: Pentazocine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Quantitative Susceptibility Biomarker and Brain Structural Property for Cerebral Cavernous Malformation Related Epilepsy
Status: RECRUITING
Conditions: Cavernous Malformation, Cerebral|Cavernous Angioma|Cavernous Hemangioma|Cavernous Hemangioma of Brain|Seizures|Seizures, Epileptic|Epilepsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: NeuroRegen Scaffold™ Combined With Stem Cells for Chronic Spinal Cord Injury Repair
Status: UNKNOWN
Conditions: Spinal Cord Injury
Interventions: BIOLOGICAL: NeuroRegen scaffold/mesenchymal stem cells transplantation|BIOLOGICAL: NeuroRegen scaffold/neural stem cells transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Ablation for the Pulmonary Focal Pure Ground Glass Opacity (pGGO)
Status: UNKNOWN
Conditions: Pulmonary Lesions
Interventions: PROCEDURE: cryotherapy or radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Outpatient Study Investigating Non-prescription Treatments for COVID-19
Status: TERMINATED
Conditions: COVID-19
Interventions: OTHER: chlorine dioxide|DIETARY_SUPPLEMENT: zinc acetate|DRUG: Famotidine|OTHER: placebo|DIETARY_SUPPLEMENT: lactoferrin, green tea extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erbium Vaginal Laser for the Treatment of Stress Urinary Incontinence
Status: UNKNOWN
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: Erbium laser|DEVICE: Sham laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Beta-1,3/1,6-D-Glucan Ganoderma Lucidum on Ulcerative Colitis
Status: UNKNOWN
Conditions: Ulcerative Colitis
Interventions: DRUG: Beta-1,3/1,6-D-Glucan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Horse ATG/CsA in Aplastic Anemia Patients Unresponsive to or With a Suboptimal Response to Rabbit ATG/CsA Treatment
Status: COMPLETED
Conditions: Anemia, Aplastic|Anemia, Hypoplastic
Interventions: DRUG: h-ATG (ATGAM )|DRUG: Cyclosporine (Gengraf )
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty
Status: UNKNOWN
Conditions: Femoral Neck Fractures|Postoperative Complications|Inflammatory Response|Postoperative Delirium|Postoperative Cognitive Dysfunction
Interventions: PROCEDURE: hip arthroplasty|DRUG: Total Intravenous Anesthesia and Peripheral nerve blocks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety of and Immune Response to an HIV DNA Plasmid Vaccine Followed by HIV Adenoviral Vector Vaccine in Healthy African Adults
Status: WITHDRAWN
Conditions: HIV Infections
Interventions: BIOLOGICAL: VRC-HIVDNA016-00-VP|BIOLOGICAL: VRC-HIVADV014-00-VP|BIOLOGICAL: Vaccine placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Pectointercostal Fascial Plane Block (PIFB) Alone Versus PIFB With Rectus Sheath Block (RSB) in Cardiac Surgery
Status: RECRUITING
Conditions: Coronary Artery Disease|Postoperative Pain|Respiratory Failure
Interventions: DRUG: Rectus sheath block with bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Tolerance Study for the Treatment of Varicose Ulcers by Cyanoacrylate Glue (ETUVVE)
Status: COMPLETED
Conditions: Venous Leg Ulcer
Interventions: PROCEDURE: Endovenous treatment|DEVICE: Cyanoacrylate glue
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Random Noise Stimulation to Enhance Cortical Drive & Improve Hand Function
Status: COMPLETED
Conditions: Spinal Cord Injuries|Tetraplegia|Cervical Spinal Cord Injury
Interventions: OTHER: transcranial Random Noise Stimulation (tRNS)|OTHER: transcranial Direct Current Stimulation (tDCS)|OTHER: sham-stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Heart and Lung Function Monitoring System
Status: COMPLETED
Conditions: Heart Diseases|Lung Diseases
Interventions: DEVICE: Integrated CardioRespiratory System|DEVICE: Transthoracic Echocardiography (TTE)|DEVICE: Electrocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effect of Liraglutide on Weight and Appetite in Obese Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Preliminary Efficacy Study of SA4503 in Subjects Recovering From Ischemic Stroke
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: placebo|DRUG: SA4503 Low|DRUG: SA4503 High
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carboplatin, Docetaxel, Bevacizumab, and Erlotinib Versus Chemotherapy Alone in Resected NSCLC
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Docetaxel/Carboplatin/Bevacizumab/Erlotinib|DRUG: Docetaxel/Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Immune Response to Three Different Prime-Boost HIV Vaccine Regimens in Healthy, HIV-Uninfected Adults
Status: WITHDRAWN
Conditions: HIV Infections
Interventions: BIOLOGICAL: DNA Nat-B env vaccine|BIOLOGICAL: NYVAC Nat-B env vaccine|BIOLOGICAL: DNA CON-S env vaccine|BIOLOGICAL: NYVAC CON-S env vaccine|BIOLOGICAL: DNA Mosaic env vaccine|BIOLOGICAL: NYVAC Mosaic env vaccine|BIOLOGICAL: Placebo|DEVICE: Biojector 2000® Needle-Free Injection Management System™ (Biojector 2000®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Optimal Sensing in Atrial Tachyarrhythmia's Study
Status: TERMINATED
Conditions: Sick Sinus Syndrome|Paroxysmal Atrial Fibrillation
Interventions: DEVICE: Accent Pacemaker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Aggressive Fluid Hydration to Prevent Post ERCP Pancreatitis
Status: COMPLETED
Conditions: Pancreatitis
Interventions: OTHER: Aggressive Intravenous Hydration Group|OTHER: Standard Fluids Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Passive VS Active VR on HPT Using the Thermal Sensory Analyzer With a Peltier-Based Contact Thermode
Status: RECRUITING
Conditions: Pain|Anxiety
Interventions: BEHAVIORAL: Oculus Go headset without active intervention|BEHAVIORAL: Oculus Go headset with active intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Improving Varenicline Adherence and Outcomes in Homeless Smokers
Status: COMPLETED
Conditions: Tobacco Use Cessation
Interventions: OTHER: Varenicline plus Motivational Interviewing counseling|OTHER: Varenicline without counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects on Respiratory Mechanics of Two Different Ventilation Strategies During Robotic-Gynecological Surgery
Status: COMPLETED
Conditions: Respiratory Mechanics|Mechanical Ventilation Complication
Interventions: OTHER: Protective ventilation group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Phase 2, Open Label, PK Study of TLC599 in Subject With Osteoarthritis of the Knee
Status: COMPLETED
Conditions: OSTEOARTHRITIS OF THE KNEE
Interventions: DRUG: TLC599|DRUG: DSP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Trial of LH-001 vs Placebo in Healthy Participants
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DRUG: LH-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intratumoral CAVATAK (CVA21) and Ipilimumab in Patients With Advanced Melanoma (VLA-013 MITCI)
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: CAVATAK|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Valsartan and Amlodipine in Blood Pressure Management: Fixed-Dose vs. Free Drug Therapy
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: valsartan-amlodipine 80/5 mg FDC|DRUG: valsartan 80 mg and amlodipine 5 mg as free combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Symptom Control With or Without Docetaxel in Treating Patients With Relapsed Esophageal Cancer or Stomach Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Gastroesophageal Junction|Esophageal Cancer|Gastric Cancer|Nausea and Vomiting|Pain
Interventions: DRUG: docetaxel|DRUG: steroid therapy|OTHER: questionnaire administration|PROCEDURE: nausea and vomiting therapy|PROCEDURE: pain therapy|PROCEDURE: quality-of-life assessment|PROCEDURE: standard follow-up care|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Lamotrigine 25 mg Chewable Tablets of Dr.Reddy's Under Fasting Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lamotrigine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II, Open Label, Escalating Dose, Pilot Study to Assess Effect, Safety, Tolerability and PK of Multiple SC Doses of Drisapersen in Patients With Duchenne Muscular Dystrophy and to Assess the Potential for IV Dosing as an Alternative Route of Administration
Status: TERMINATED
Conditions: Muscular Dystrophies
Interventions: DRUG: Drisapersen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of AL-53817 and AL-78843 Ophthalmic Solutions for Allergic Conjunctivitis
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: AL-53817 Ophthalmic Solution, 0.1%|DRUG: AL-78843 Ophthalmic Solution, 0.03%|DRUG: Dexamethasone Ophthalmic Suspension, 0.1%|DRUG: AL-53817 Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate in Treating Patients With Recurrent Small Cell Lung Cancer
Status: COMPLETED
Conditions: Recurrent Small Cell Lung Cancer
Interventions: DRUG: imatinib mesylate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgery Followed by Radiation Therapy and Chemotherapy in Treating Patients With Cancer of the Pancreas
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: fluorouracil|DRUG: leucovorin calcium|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Pilot RCT to Test Effectiveness of the ACE4 (Activity Challenge- 4 Areas) for Depression and Anxiety
Status: UNKNOWN
Conditions: Anxiety Disorder; Mixed With Depression (Mild)
Interventions: BEHAVIORAL: ACE4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Bempegaldesleukin (BEMPEG: NKTR-214) in Combination With Nivolumab in Children, Adolescents and Young Adults With Recurrent or Treatment-resistant Cancer
Status: TERMINATED
Conditions: Ependymoma|Ewing Sarcoma|High-grade Glioma|Leukemia and Lymphoma|Medulloblastoma|Miscellaneous Brain Tumors|Miscellaneous Solid Tumors|Neuroblastoma|Relapsed, Refractory Malignant Neoplasms|Rhabdomyosarcoma
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: NKTR-214
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Efficacy of Lidocaine Spray Versus Vaginal Misoprostol in IUD Insertion
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: lidocaine spray|DRUG: vaginal misoprostol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Plerixafor in Treating Patients With Multiple Myeloma Previously Treated With Lenalidomide and Planning to Undergo Autologous Stem Cell Transplant
Status: COMPLETED
Conditions: Multiple Myeloma|Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma
Interventions: DRUG: plerixafor|DRUG: filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Partial Hydrolyzed Guar Gum in High Stoma Output Management Among Cancer Patients With Ileostomy
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DIETARY_SUPPLEMENT: PHGG|OTHER: conventional care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ICT-enabled Social-emotional Learning: Development of Responsibility and Well-being in the Educational Environment
Status: ACTIVE_NOT_RECRUITING
Conditions: Adolescent - Emotional Problem
Interventions: OTHER: ICT-enabled Social-emotional Learning
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Open-Label Safety Study to Evaluate Imiquimod Cream, 5% for Large Areas of Actinic Keratosis
Status: COMPLETED
Conditions: Keratosis
Interventions: DRUG: imiquimod cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety and Tolerability of a Probioitc
Status: COMPLETED
Conditions: Healthy Volunteers|Tolerability|Safety
Interventions: OTHER: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Therapeutic Response to Tumor Necrosis Factor-alpha (TNF-alpha) Antagonists in Rheumatoid Arthritis.
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Inflammatory Arthritis|Ankylosing Spondylitis
Interventions: BIOLOGICAL: Infliximab: Adalimumab; Etanercept;
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Erythropoietin to Improve Critical Care Patient Outcomes
Status: UNKNOWN
Conditions: Anemia|Intensive Care
Interventions: DRUG: Erythropoietin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Relative Bioavailability of Process Variants of Selumetinib in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers Bioequivalence or Bioavailability Study
Interventions: DRUG: selumetinib 75mg single dose|DRUG: selumetinib 75mg single dose|DRUG: selumetinib 75mg single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Safety, Tolerability and Efficacy of BMN 110 in Subjects With Mucopolysaccharidosis IVA
Status: COMPLETED
Conditions: MPS IV A
Interventions: DRUG: BMN 110
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gabapentin for Abstinence Initiation in Alcohol Dependence
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: Gabapentin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Swallowing Difficulties in ICU Patients [Synkebesvær Hos Intensivpatienter]
Status: UNKNOWN
Conditions: Deglutition Disorders|Critical Illness
Interventions: DIAGNOSTIC_TEST: Yale Swallow Protocol|DIAGNOSTIC_TEST: FEES (fiberoptic endoscopic evaluation of swallowing)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Medial Forefoot Block for Analgesia After Foot Surgery
Status: COMPLETED
Conditions: Hallux Valgus
Interventions: PROCEDURE: Landmark guided ankle block.|PROCEDURE: PNS guided block.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Benefits of Insoles With Real-Time Alert and Foot Self-Care Education
Status: NOT_YET_RECRUITING
Conditions: Diabetes Complications
Interventions: BEHAVIORAL: A 90-minute self-care education + bi-weekly 30-minute one-on-one follow-up phone discussion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Proof Of Mechanism Study To Determine Efficacy Of PF-04455242 In Blocking Spiradoline (PF-00345768) Stimulated Prolactin Release
Status: COMPLETED
Conditions: Bipolar Depression
Interventions: DRUG: PF-04455242|DRUG: spiradoline|OTHER: Placebo|DRUG: spiradoline|DRUG: PF-04455242|DRUG: spiradoline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interleukin-2 or Observation Following Radiation Therapy, Combination Chemotherapy, and Peripheral Stem Cell Transplantation in Treating Patients With Recurrent Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: filgrastim|DRUG: cyclophosphamide|DRUG: etoposide|RADIATION: radiation therapy|PROCEDURE: peripheral blood stem cell transplantation|PROCEDURE: bone marrow ablation with stem cell support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Once-Weekly Rifapentine and Isoniazid on the Steady State Pharmacokinetics of Dolutegravir and Darunavir Boosted With Cobicistat in Healthy Volunteers
Status: COMPLETED
Conditions: HIV Infected Population With Latent Tuberculosis
Interventions: DRUG: rifapentene (RPT)|DRUG: darunavir/cobicistat (DRV/c)|DRUG: Isoniazid (INH)|DIETARY_SUPPLEMENT: Pyridoxine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate Drug-Drug Interaction of Larotinib With Itraconazole and Rifampin in Healthy Adult Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: Larotinib|DRUG: Rifampin|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Subjective Sleep Study of a Prototype Nasal Dilator
Status: COMPLETED
Conditions: Sleep Disorders|Congestion, Nasal
Interventions: DEVICE: Prototype Nasal Dilator|DEVICE: Marketed Nasal Strip|DEVICE: Placebo Nasal Strip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Osimertinib in Treating Patients With Stage IIIB-IV or Recurrent Non-small Cell Lung Cancer With EGFR Exon 20 Insertion Mutations
Status: RECRUITING
Conditions: Advanced Lung Non-Small Cell Carcinoma|Recurrent Lung Non-Small Cell Carcinoma|Stage IIIB Lung Non-Small Cell Cancer AJCC v7|Stage IV Lung Non-Small Cell Cancer AJCC v7
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography with Contrast|PROCEDURE: Magnetic Resonance Imaging|DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Recovery After Laparoscopic vs. Open Liver Resection
Status: COMPLETED
Conditions: Postoperative Complications|Liver Diseases|Physical Stress|Surgery
Interventions: OTHER: Ergometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study of Two Dentinal Hypersensitivity Treatments Used With Normal Oral Hygiene
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: DEVICE: Potassium oxalate|DRUG: Sodium fluoride paste|DRUG: Stannous fluoride paste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety of Zileuton (Zyflo®) in Combination With Dasatinib (Sprycel®) in Chronic Myelogenous Leukemia
Status: TERMINATED
Conditions: Chronic Myelogenous Leukemia
Interventions: DRUG: Zileuton (Zyflo®) Dasatinib (Sprycel®)|DRUG: Dosing with Zileuton/Dasatinib in CML|DRUG: Daily dosing of Zileuton/Dasatinib|DRUG: Daily dosing with Zileuton/Dasatinib for CML
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Confirming the Effectiveness of Online Guided Self-Help Family-Based Treatment for Adolescent Anorexia Nervosa
Status: RECRUITING
Conditions: Anorexia Nervosa
Interventions: BEHAVIORAL: Online Guided Self-Help-Family-based Treatment|BEHAVIORAL: FBT via Videoconferencing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Auricular Acupuncture vs. Sham Procedure for Pain Control After Knee Arthroplasty
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DEVICE: Auricular acupuncture|DEVICE: Sham auricular acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sofosbuvir Containing Regimens in Treatment of COVID 19 Patients
Status: UNKNOWN
Conditions: Covid19
Interventions: DRUG: Sofosbuvir|DRUG: Daclatasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diaphragmatic Electrical Activity in Preterm Infants on Non-Invasive Ventilation
Status: UNKNOWN
Conditions: Respiratory Distress Syndrome, Newborn|Chronic Lung Disease of Newborn (Diagnosis)
Interventions: DEVICE: Drager VN500 Ventilator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gefitinib and Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III or Stage IV Head and Neck Cancer
Status: TERMINATED
Conditions: Stage III Squamous Cell Carcinoma of the Hypopharynx|Stage III Squamous Cell Carcinoma of the Larynx|Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage III Squamous Cell Carcinoma of the Oropharynx|Stage IV Squamous Cell Carcinoma of the Hypopharynx|Stage IV Squamous Cell Carcinoma of the Larynx|Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IV Squamous Cell Carcinoma of the Oropharynx
Interventions: DRUG: gefitinib|RADIATION: radiation therapy|DRUG: cisplatin|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficiency of Closed Kinetic Chain Exercises Versus Proprioceptive Exercises Patient With Hemophilia
Status: RECRUITING
Conditions: Hemophilia A|Hemophilia B
Interventions: OTHER: Closed Chain Exercise Group|OTHER: Proprioceptive Exercise Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of Platelet-rich Plasma (PRP) on Advanced Endoscopic Resection Techniques
Status: COMPLETED
Conditions: Platelet-rich Plasma|Endoscopic Mucosal Resection|Endoscopic Submucosal Dissection
Interventions: DRUG: Platelet-rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Preoperative Methylprednisolone to Patients Suspected of Appendicitis Undergoing Laparoscopy
Status: COMPLETED
Conditions: Suspected Appendicitis
Interventions: DRUG: Methylprednisolone|DRUG: 0.9% Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rapid Analysis and Response Evaluation of Combination Anti-Neoplastic Agents in Rare Tumors (RARE CANCER) Trial: RARE 1 Nilotinib and Paclitaxel
Status: RECRUITING
Conditions: Neoplasms
Interventions: DRUG: Nilotinib and Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Poplar-type Propolis Dry Extract ESIT12 : Immunomodulation Efficacy Study
Status: RECRUITING
Conditions: Upper Respiratory Tract Infection (URTI)
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Verum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Non-Anemic Iron Deficiency in Pregnancy
Status: RECRUITING
Conditions: Non-anemic Iron Deficiency
Interventions: DRUG: Ferrous sulfate|DRUG: Prenatal|DRUG: Docusate Sodium|DRUG: Ascorbic Acid 500Mg Tab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Systemic Microvascular Reactivity in Patients With Resistant Hypertension
Status: RECRUITING
Conditions: Arterial Hypertension|Resistant Hypertension|Microvascular Rarefaction|Endothelial Dysfunction
Interventions: DIAGNOSTIC_TEST: Evaluation of systemic skin microvascular endothelial function
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p