pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Quality of Life and Target Achievement After Treatment of Patients With Stable Angina Pectoris
Status: WITHDRAWN
Conditions: Stable Angina Pectoris
Interventions: PROCEDURE: Percutaneous coronary angioplasty (PCI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycopyrrolate Prophylaxis for Prevention of Bradyarrhythmia During Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Bradyarrhythmia|Cardiac Arrest|Tachycardia|Asystole
Interventions: DRUG: Normal Saline|DRUG: Glycopyrrolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Bifidobacterium Therapy in Patients With Advanced Liver Cancer Receiving Immunotherapy
Status: RECRUITING
Conditions: Advanced Hepatocellular Carcinoma
Interventions: DRUG: Bifidobacterium Bifidum Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Patient-Centered Mobile App Self-Management Program for Osteoarthritis
Status: RECRUITING
Conditions: Osteoarthritis
Interventions: BEHAVIORAL: A mobile app self-management (mSM) program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Validation Study of the Accuracy of E/e' in Estimating Left Ventricular Filling Pressure
Status: COMPLETED
Conditions: Doppler Echocardiography
Interventions: PROCEDURE: Echo-Doppler examination and left heart catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Recovery Time of Quadriceps Strength After Total Knee Arthroplasty (TKA): The Effect of Quadriceps Incision Length
Status: COMPLETED
Conditions: Osteoarthritis of Knee
Interventions: PROCEDURE: Quadriceps incision < 2 cm|PROCEDURE: Quadriceps incision 2-4 cm|PROCEDURE: Quadriceps incision > 4 cm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Arrhythmia in Patients With End-Stage Renal Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: End Stage Renal Disease on Dialysis|Cardiac Arrhythmia|Diabetes Mellitus|Hypoglycemia
Interventions: DEVICE: Loop recorder (Reveal LINQ, Medtronic)|DEVICE: Continuous Glucose Measurement (G6, Dexcom)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mechanical Ventilation in Severe Brain Injury: The Effect of Positive End Expiratory Pressure on Intracranial Pressure
Status: TERMINATED
Conditions: Intracranial Hypertension|Critical Illness|Brain Injuries|Lung Injury|Respiratory Failure|Positive-Pressure Respiration, Intrinsic
Interventions: OTHER: PEEP titrated mechanical ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Curcumin and Retinal Study
Status: RECRUITING
Conditions: Bioavailability|Gut Microbiome|Safety
Interventions: DRUG: Low curcumin group|DRUG: High curcumin group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Human Milk Oligossaccharide and Acetate Production in Vivo
Status: COMPLETED
Conditions: Obesity|Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: Human Milk Oligossaccharide|DIETARY_SUPPLEMENT: Maltodextrin|DIETARY_SUPPLEMENT: Human Milk Oligossaccharide and resistant starch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Head-to-head Comparative Study of 18F-PSMA-1007 PET/CT and 18F-FDG PET/CT Imaging in Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: 18F-PSMA-1007|DRUG: 18F-FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Keloid Volume and Symptoms Reduction Between Intralesional Umbilical-Cord Mesenchymal Stem Cells, Its Conditioned Medium, and Triamcinolone Acetonide Injection as Keloid Therapy: A Randomised Controlled Trial
Status: COMPLETED
Conditions: Keloid|Stem Cell
Interventions: BIOLOGICAL: umbilical cord-derived mesenchymal stem cells (UC-MSC)|BIOLOGICAL: umbilical cord-derived mesenchymal stem cells conditioned medium (UC-CM)|DRUG: Triamcinolone Acetonide (TA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarkers in Samples From Young Patients With Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: GENETIC: polymerase chain reaction|GENETIC: protein expression analysis|GENETIC: western blotting|OTHER: flow cytometry|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Soft Tissue Mobilization for Lumbopelvic Pain in the Third Trimester of Pregnancy
Status: COMPLETED
Conditions: Low Back Pain|Pregnancy
Interventions: PROCEDURE: Soft Tissue Mobilization|PROCEDURE: Soft Tissue Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing and Piloting a Multi-component Technology-based Care Intervention to Address Patient Symptoms and Caregiver Burden in Home Hospice. Phase 1.
Status: COMPLETED
Conditions: Home Hospice
Interventions: OTHER: I-HoME
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Pharmacokinetics Study Comparing PF-06438179 and Infliximab in Healthy Volunteers (REFLECTIONS B537-01)
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: PF-06438179|BIOLOGICAL: Remicade|BIOLOGICAL: Remicade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prehabilitation in Adult Patients Following Selective Cardiac Surgery: A Randomized Controlled Trial
Status: UNKNOWN
Conditions: Enhanced Recovery|Prehabilitation|Cardiac Surgery
Interventions: BEHAVIORAL: Prehabilitation|BEHAVIORAL: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Breast-Conserving Therapy Compared With Mastectomy Followed By Radiation Therapy in Treating Women With Locally Advanced Breast Cancer Previously Treated With Chemotherapy
Status: TERMINATED
Conditions: Breast Cancer
Interventions: PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Oligometastases of the LIVer Treated With Chemotherapy With ou Without Extracranial Stereotactic Body Radiation Therapy in Patients With Colorectal Cancer
Status: WITHDRAWN
Conditions: Liver Metastases|Colorectal Cancer
Interventions: RADIATION: SBRT|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chloride High Level Of Resuscitation Infusion Chloride High Level Of Resuscitation Infusion Delivered Evaluation
Status: UNKNOWN
Conditions: Shock|Critical Illness
Interventions: DRUG: Lower chloride fluids (Hartmann's solution and Plasmalyte®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the C8 Dermatomal Block With Photoplethysmographic Amplitude After Interscalene Brachial Plexus Block
Status: RECRUITING
Conditions: Brachial Plexus Block|Oximetry
Interventions: PROCEDURE: Interscalene brachial plexus block targeting the C5-to-C6 nerve roots|PROCEDURE: Interscalene brachial plexus block targeting the C5-to-C8 nerve roots
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Serotonergic Pharmacotherapy for Agitation of Dementia
Status: COMPLETED
Conditions: Dementia|Alzheimer Disease|Dementia, Vascular
Interventions: DRUG: Citalopram [Celexa]|DRUG: Perphenazine [Trilafon]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Outcome of a Triple Inner Branched Aortic Arch Stentgraft. A Prospective, Multicenter Registry.
Status: RECRUITING
Conditions: Aortic Arch|Aortic Arch Aneurysm|Dissection of Aortic Arch|Triple Branch
Interventions: DEVICE: Triple inner branched arch stentgraft
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Topical Application to Relieve Gout: Efficacy Trial & Safety (TARGETS)
Status: COMPLETED
Conditions: Gout
Interventions: DRUG: DYV700|DRUG: Placebo|DRUG: Colchicine 0.6 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Steroids for Rhinoplasty: Pain, Nausea, Edema and Ecchymosis
Status: NOT_YET_RECRUITING
Conditions: Edema|Bruising|Nasal Obstruction|Postoperative Pain|Postoperative Nausea|Postoperative Complications
Interventions: DRUG: Medrol 4 MG Oral Tablet Includes Medrol Dosepak
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the SREC
Status: NOT_YET_RECRUITING
Conditions: Electronic Cigarette Use
Interventions: DEVICE: Standardized research e-cigarette (SREC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rectal Preserving Treatment for Early Rectal Cancer. A Multi-centred Randomised Trial of Radical Surgery Versus Adjuvant Chemoradiotherapy After Local Excision for Early Rectal Cancers
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: RADIATION: Adjuvant chemoradiotherapy|PROCEDURE: Additional TME surgery|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-operative Olanzapine as Prophylactic Antiemetic in Oncologic Patients
Status: COMPLETED
Conditions: Postoperative Nausea|Postoperative Nausea and Vomiting
Interventions: DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Cerebral Circulation in Critically Ill Children
Status: COMPLETED
Conditions: Arterial Hypotension|Shock|Cerebral Lesion
Interventions: DEVICE: Near InfraRed Spectroscopy assessment|DEVICE: Transcranial Doppler Ultrasound assessment|DEVICE: Cardiac output assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Acoustic Stimulation, Sleep, and Cognitive-Emotional Processes in Young Adults With Anxiety and Depression Symptoms
Status: RECRUITING
Conditions: Acoustic Stimulation
Interventions: DEVICE: Acoustic Stimulation (STIM)|DEVICE: No Acoustic Stimulation (SHAM)|DEVICE: Daily acoustic stimulation (STIM2)|DEVICE: No daily acoustic stimulation (SHAM2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of Sitagliptin to Decrease Microalbuminuria
Status: TERMINATED
Conditions: Type 2 Diabetes|Microalbuminuria
Interventions: DRUG: Sitagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hip and Knee Scoring System to Predict Complication Rate and Candidacy for Total Hip and Knee Arthroplasty
Status: WITHDRAWN
Conditions: Osteoarthritis, Knee|Osteoarthritis, Hip
Interventions: BEHAVIORAL: Risk Status Optimization
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Prospective RCT on Post Prostatectomy Urine Leak
Status: UNKNOWN
Conditions: Prostate Cancer|Urinary Incontinence
Interventions: DRUG: Duloxetine|BEHAVIORAL: Pelvic Floor Muscle Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of Chemotherapy on the Uptake and Retention of Carbon 11 Methionine in Prostate Cancer Patients
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: C11 Methionine PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The PROtective Effect of SulforAphaNe on Chronic Low-grade Inflammation in Healthy Participants
Status: COMPLETED
Conditions: Inflammation
Interventions: OTHER: BroccoCress|OTHER: Affilla Cress
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Comparison of 32mm and 28mm Head Components in Alumina-alumina Total Hip Arthroplasty
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Hip
Interventions: DEVICE: 32mm ceramic head group|DEVICE: 28mm ceramic head group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Abemaciclib and Letrozole in Patients With Estrogen Receptor-positive Rare Ovarian Cancer
Status: RECRUITING
Conditions: Low Grade Serous Ovarian Carcinoma|Adult Type Granulosa Cell Tumor
Interventions: DRUG: Abemaciclib|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality in Invasive Techniques in Physiotherapy
Status: NOT_YET_RECRUITING
Conditions: Pain
Interventions: OTHER: Dry needling and immersive virtual reality|OTHER: Dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Olfactory Stimulation for Very Low Birth Weight Infants
Status: COMPLETED
Conditions: Very Low Birth Weight Infant
Interventions: BEHAVIORAL: Olfactory stimulation|BEHAVIORAL: Routine nursing care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Patients With Relapse Remitting Multiple Sclerosis (RRMS): Candidates for MS Therapy Change
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: Fingolimod|DRUG: Standard MS DMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-Blind Randomized Placebo-Controlled Trial of a Proprietary Full Hemp Flower Formulation for Long COVID
Status: NOT_YET_RECRUITING
Conditions: Post-acute COVID-19 Syndrome
Interventions: OTHER: Xltranplus, Xltran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of EDP-514 in Healthy Subjects (Part 1) and Patients With Chronic Hepatitis B Virus Infection (Part 2)
Status: COMPLETED
Conditions: Chronic HBV Infection
Interventions: DRUG: EDP-514|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Sevoflurane Concentration for Intubation in Combination of Clincal Remifentanil Doses
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Intubation|DRUG: Remifentanil|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Oral Glutathione As A Skin Whitening Agent
Status: COMPLETED
Conditions: Glutathione|Skin Whitening
Interventions: DRUG: Glutathione|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lung Perfusion Measured With Dual-Energy CT in Patients With Chronic Thromboembolic Pulmonary Hypertension: Comparative Study With Right Heart Catheterization and V/Q
Status: UNKNOWN
Conditions: Multidetector Computed Tomography|Pulmonary Embolism and Thrombosis|Hypertension Pulmonary Secondary
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rural Interventions for Screening Effectiveness
Status: COMPLETED
Conditions: Breast, Cervical or Colorectal Cancer Screening Needed
Interventions: BEHAVIORAL: Educational Intervention via brochure|BEHAVIORAL: Educational Intervention via DVD|BEHAVIORAL: Educational Intervention-DVD & Telephone Based Navigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: VinCaT: Vinorelbine, Carboplatin and Trastuzumab in Advanced Her-2 Positive Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: vinorelbine|DRUG: carboplatin|DRUG: trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-inflammatory Effect of Atorvastatin on Graft Donor Kidney
Status: COMPLETED
Conditions: Renal Insufficiency
Interventions: DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Evaluate Topical Sodium Thiosulfate Therapy for Calcinosis Cutis
Status: WITHDRAWN
Conditions: Calcinosis Cutis
Interventions: DRUG: Sodium thiosulfate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Doppler Ultrasound Measurement of Changes in Uterine Artery Blood Flow in Normal First Trimester Pregnancies and Its Prediction on Abortion
Status: NOT_YET_RECRUITING
Conditions: Abnormal Uteroplacental Circulation
Interventions: OTHER: Doppler ultrasound measurement of changes in uterine artery blood flow
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 2 Study of Panitumumab in Patients With Cetuximab-refractory Metastatic Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating The Impact Of Donepezil Hydrochloride (Aricept) On Behavioral And Psychological Symptoms In Patients With Severe Alzheimer's Disease
Status: WITHDRAWN
Conditions: Severe Alzheimer's Disease
Interventions: DRUG: Donepezil Hydrochloride (Aricept)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a SlimFast Internet Behavioral Weight Loss Program
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Internet weight loss with SlimFast and human counseling|BEHAVIORAL: Internet weight loss with SlimFast and computer counseling|BEHAVIORAL: Internet weight loss program with SlimFast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effect of Preoperative Bowel Cleansing on Postoperative Cognitive Impairment
Status: NOT_YET_RECRUITING
Conditions: POCD - Postoperative Cognitive Dysfunction|Mechanical Bowel Preparation
Interventions: PROCEDURE: mechanical bowel preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Veno-arterial ExtraCorporeal Membrane Oxygenation to Reduce Morbidity and Mortality Following Lung TransPlant
Status: RECRUITING
Conditions: The Number of Ventilator-free Days in the 28 Days Following LT
Interventions: PROCEDURE: Veno-arterial extracorporeal membrane oxygenation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and Thymalfasin for pMMR/MSS Locally Advanced Mid-low Rectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Rectal Cancer
Interventions: DRUG: capecitabine|DRUG: tislelizumab|DRUG: thymalfasin|RADIATION: long-term radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Histological Study to Evaluate Skin Changes After PicoWay® 1064 nm and 532nm Picosecond Fractional Laser Treatment
Status: COMPLETED
Conditions: Dyschromia
Interventions: DEVICE: PicoWay 532nm fractional treatment|DEVICE: PicoWay 1064nm fractional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Guanabenz for Nonalcoholic Fatty Liver Disease
Status: UNKNOWN
Conditions: Nonalcoholic Fatty Liver|Nonalcoholic Steatohepatitis
Interventions: DRUG: Experimental: 4 mg/day of WY-8678 (guanabenz acetate)|DRUG: Experimental: 8 mg/day of WY-8678 (guanabenz acetate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR)
Status: COMPLETED
Conditions: Vesicoureteral Reflux|Urinary Tract Infections
Interventions: DRUG: Trimethoprim-Sulfamethoxazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of IDN-6556 in Patients With Severe Alcoholic Hepatitis and Contraindications to Steroid Therapy
Status: TERMINATED
Conditions: Alcoholic Hepatitis
Interventions: DRUG: IDN-6556|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Catheter-based Peripheral Regional Anesthesia After Orthopedic Surgery to the Foot or Ankle
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Ropivacaine 0.2%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate Endovascular Treatment of Large Ischemic Stroke With Substantial Penumbra.
Status: TERMINATED
Conditions: Acute Ischemic Stroke
Interventions: PROCEDURE: Endovascular treatment in addition of best medical treatment.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Psychological Effects of 8 Weeks Supplementation With Sceletium Tortuosum Extract
Status: UNKNOWN
Conditions: Cognitive Change|Stress, Psychological
Interventions: DIETARY_SUPPLEMENT: Sceletium tortuosum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Methods for Managing Intrusive Thoughts
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: BEHAVIORAL: Gradual Exposure (EXP-G)|BEHAVIORAL: Variable Exposure (EXP-V)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapy for Erectile Dysfunction Adaptation of ACT for Compliance With an Erectile Rehabilitation Program
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BEHAVIORAL: Sexual Medicine Rehabilitation Program + nurse practitioner information phone calls|BEHAVIORAL: Sexual Medicine Rehabilitation Program + Acceptance and Commitment Therapy for Erectile Dysfunction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Transcranial Direct Current Stimulation (tDCS) as add-on Treatment for Resistant Major Depression
Status: COMPLETED
Conditions: Resistant Major Depression
Interventions: DEVICE: transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between Obeticholic Acid Versus Vitamin E in Patients With Non-alcoholic Steatohepatitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-alcoholic Steatohepatitis
Interventions: DRUG: Obeticholic Acid Oral Tablet|DRUG: Vit E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Oral Loading Dose of Cholecalciferol in Non-Alcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: DRUG: Cholecalciferol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Daratumumab and Ibrutinib for the Treatment of Relapsed or Refractory Chronic Lymphocytic Leukemia, DIRECT Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Chronic Lymphocytic Leukemia|Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Small Lymphocytic Lymphoma
Interventions: BIOLOGICAL: Daratumumab|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Bispecific Antibody MCLA-145 in Patients With Advanced or Metastatic Malignancies
Status: UNKNOWN
Conditions: Advanced Cancer|Solid Tumor, Adult|B-cell Lymphoma, Adult
Interventions: DRUG: MCLA-145
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OSsIRIS Study - A Post-market Clinical Follow-up Investigation.
Status: RECRUITING
Conditions: Surgically Created Bone Defects or Bone Defects/Voids Resulting From Traumatic Injury
Interventions: DEVICE: Bone grafting for the treatment of surgically created bone defects or bone defects/voids resulting from traumatic injury to promote healing in the pelvis, upper and lower extremities.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluate the Safety, Tolerability and Pharmacokinetic Profile of TPN672 Tablets Maleate in Patients With Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DRUG: TPN-672
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects for Midface Improvement When Pairing a Biostimulator With a Skincare Regimen
Status: ACTIVE_NOT_RECRUITING
Conditions: Photodamaged Skin|Volume Deficiency of the Midface
Interventions: COMBINATION_PRODUCT: Sculptra and Alastin Restorative Skin Complex|COMBINATION_PRODUCT: Sculptra and CeraVe Daily Moisturizing Lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study for Patients Who Have Benefited and Tolerated Prior Panitumumab Treatment
Status: COMPLETED
Conditions: Colorectal Cancer|Non-Small Cell Lung Cancer|Prostate Cancer|Solid Tumors|Advanced Renal Cell Carcinoma
Interventions: DRUG: Panitumumab (ABX-EGF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Granulocyte Colony-stimulating Factor (G-CSF), Trastuzumab, and Vinorelbine on Immune Cell Function
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: G-CSF|DRUG: trastuzumab|DRUG: vinorelbine|DRUG: G-CSF|DRUG: saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AT1R Blockade and Periodic Breathing During Sleep in Hypoxia
Status: COMPLETED
Conditions: Sleep Disordered Breathing|Hypoxia|Respiration; Sleep Disorder|Chemoreceptor Apnea
Interventions: OTHER: Hyperoxic Hypercapnic Ventilatory Response Test|OTHER: Hypoxic Hypercapnic Ventilatory Response Test|OTHER: Repeated Hypoxic Apneas|OTHER: Hypoxic Sleep Study|DRUG: Losartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Efficacy of Electromagnetic Therapy on Postoperative Surgical Pain After Uni- and Bilateral Inguinal Hernia Repair.
Status: COMPLETED
Conditions: Inguinal Hernias
Interventions: DEVICE: Magnetic field therapy device|DEVICE: Non magnetic field therapy device.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Intraoperative Probe-based Confocal Laser Endomicroscopy in Digestive and Endocrine Surgery: a Pilot Study
Status: COMPLETED
Conditions: All Surgical Conditions Usually Necessitating Frozen Section|Malignant Tumor|Inflammatory Disease|Benign Tumor
Interventions: DEVICE: pCLE|DRUG: IV fluorescein administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of taVNS on Motivation in MDD With Anhedonia
Status: ENROLLING_BY_INVITATION
Conditions: Depression
Interventions: DEVICE: transcutaneous auricular vagus nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Injectable Versus Oral Naltrexone Treatment of Alcohol Dependence In Serious Mental Illness (SMI)
Status: COMPLETED
Conditions: Bipolar Disorders|Schizophrenia|Schizoaffective Disorders|Alcohol Dependence
Interventions: DRUG: injectable naltrexone|DRUG: oral naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevena Vascular Groin Wound Study
Status: UNKNOWN
Conditions: Wound Infection|Peripheral Arterial Disease|Aneurysm|Surgical Wound Dehiscence
Interventions: DEVICE: Prevena Care|DEVICE: Dry gauze dressing care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atorvastatin Versus Rosuvastatin on Contrast Induced Acute Kidney Injury (PRATO-ACS 2)
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Rosuvastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Azacytidine Prior to in Vivo T-cell Depleted Allo Stem Cell Transplant for Patients With Myeloid Malignancies in CR
Status: COMPLETED
Conditions: Leukemia, Erythroblastic, Acute|Myelodysplastic Syndromes
Interventions: DRUG: 5-Azacytidine|DRUG: Fludarabine|DRUG: Melphalan|DRUG: Alemtuzumab|RADIATION: Total Body Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Opioid Misuse and Overdose Deaths Among Hispanic/Latinx Adolescents: A Family-based Perspective
Status: NOT_YET_RECRUITING
Conditions: Opioid Misuse
Interventions: BEHAVIORAL: Educational videos
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Pegylated IFN-alpha 2B Added to Dasatinib in Newly Diagnosed Chronic Phase Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia, Myeloid, Chronic-Phase
Interventions: DRUG: Dasatinib + PegIFN
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain in Parkinson's Disease: Exploration of the Serotonin System in Positron Emission Tomography (PET [18F]-MPPF)
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DIAGNOSTIC_TEST: Clinical assessment|DIAGNOSTIC_TEST: Pain characteristics assessment|DIAGNOSTIC_TEST: MRI|DIAGNOSTIC_TEST: Thermotest|DIAGNOSTIC_TEST: UPDRS-III Scale|DIAGNOSTIC_TEST: [18F]-MPPF PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Silk - Like Bedding Fabric Pillow Case in the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: OTHER: Silk like Pillowcase|OTHER: Cotton Pillowcase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Supine Exercise in Hepatopulmonary Syndrome Patients With Orthodeoxia
Status: RECRUITING
Conditions: Hepatopulmonary Syndrome
Interventions: DIAGNOSTIC_TEST: Upright Exercise|DIAGNOSTIC_TEST: Supine Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neurological Outcome After Erythropoietin Treatment for Neonatal Encephalopathy
Status: COMPLETED
Conditions: Hypoxic-Ischemic Encephalopathy
Interventions: DRUG: recombinant human erythropoietin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of Anti-cancerous Effect of Green, Roasted and Decaffeinated Coffee on Oral Squamous Cell Carcinoma Cell Line
Status: UNKNOWN
Conditions: Oral Squamous Cell Carcinoma
Interventions: DIETARY_SUPPLEMENT: coffee
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electrophysiological Biomarkers in MTLE Patients.
Status: TERMINATED
Conditions: Mesial Temporal Lobe Epilepsy
Interventions: DEVICE: Asynchronous distributed multi-electrode stimulation (ADMES) using an implantable neurostimulation device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Craniosacral Therapy Children's, Balance-Coordination
Status: COMPLETED
Conditions: Healthy Children
Interventions: DIAGNOSTIC_TEST: A series of questions were asked to the children's parents in a virtual questionnaire|DIAGNOSTIC_TEST: neurobehavioral aspects of the students using the "Battelle Developmental Inventory" (BDI)|PROCEDURE: Therapy sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Electrocardiographic Guidance in Accurate Peripherally Inserted Central Catheter Placement in Children.
Status: COMPLETED
Conditions: Venous Insufficiency
Interventions: DEVICE: C3 Wave ECG-based PICC Tip Confirmation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Switch Study From Hydroxyurea to Ruxolitinib for RELIEF of Polycythemia Vera Symptoms: The Relief Study
Status: COMPLETED
Conditions: Polycythemia Vera
Interventions: DRUG: Ruxolitinib|DRUG: Hydroxyurea (HU)|DRUG: HU-placebo|DRUG: Ruxolitinib-placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interest of the BRUXENSE Occlusal Splints for Bruxism Diagnosis: a Feasibility Study
Status: COMPLETED
Conditions: Bruxism, Sleep-Related
Interventions: DEVICE: BRUXENSE occlusal splint
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Single-dose Azithromycin for the Treatment of Yaws
Status: COMPLETED
Conditions: Yaws|Treponema Infection|Neglected Tropical Disease
Interventions: DRUG: Penicillin-G-benzathine|DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of the SoundBite™ Crossing System With ACTIVE Wire in Coronary CTOs.
Status: TERMINATED
Conditions: Chronic Total Occlusion of Coronary Artery
Interventions: DEVICE: SoundBite™ Crossing System Active Wire 14
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Thoracic Mobilization on Shoulder Range of Motion
Status: COMPLETED
Conditions: Shoulder Range of Motion in Healthy Individuals
Interventions: OTHER: Thoracic Mobilization|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Dose-Finding Study of SYNT001 in Subjects With Pemphigus (Vulgaris or Foliaceus)
Status: TERMINATED
Conditions: Pemphigus|Pemphigus Vulgaris|Pemphigus Foliaceus
Interventions: DRUG: ALXN1830
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Fingolimod in MS Patients in China
Status: WITHDRAWN
Conditions: Multiple Sclerosis (Relapsing Remitting)
Interventions: DRUG: fingolimod|DRUG: Placebo (6mos) + open label fingolimod (6 mos)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Comparison of Patients With Transthyretin Cardiac Amyloidosis and Patients With Heart Failure With Reduced Ejection Fraction
Status: ACTIVE_NOT_RECRUITING
Conditions: Transthyretin Amyloid Cardiomyopathy|Heart Failure
Interventions: DIAGNOSTIC_TEST: Echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: The Different Design of Orthokeratology
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Orthokeratology with aspheric wide inversion zone design in the optical zone|DEVICE: Orthokeratology with traditional spherical design in the optical zone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Low-dose Recombinant Human IL-2 for the Treatment of Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: hrIL-2 active|DRUG: hrIL-2 placebo|DRUG: MTX|DRUG: Folic Acid|DRUG: Loxoprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Armodafinil for Treating Fatigue in Adults With HIV/AIDS
Status: COMPLETED
Conditions: HIV Infections|Fatigue
Interventions: DRUG: Armodafinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maternal B12 Supplementation to Improve Infant B12 Deficiency and Neurodevelopment
Status: UNKNOWN
Conditions: Child Developmental Delay|Child Malnutrition|Maternal Exposure|Vitamin B 12 Deficiency
Interventions: DIETARY_SUPPLEMENT: B12 Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Feasibility of Novel Therapy for Duodenal Mucosal Regeneration for Type II Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes|Diabetes Type 2|Diabetes Mellitus, Type 2|Glucose Metabolism Disorders|Metabolic Disease|Endocrine System Diseases|Diabetes Mellitus
Interventions: DEVICE: The Endogenex Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficiency and Treatment Failure of Hall Versus SDF Techniques in the Management of Carious Primary Molar.
Status: UNKNOWN
Conditions: Early Childhood Caries
Interventions: PROCEDURE: SDF|PROCEDURE: Hall technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing No Mechanical Bowel Preparation With Oral Antibiotics Alone in Patients Undergoing Elective Colon Surgery
Status: RECRUITING
Conditions: Elective Colon Surgery
Interventions: OTHER: No Preparation|DRUG: Neomycin and Flagyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diabetes Therapy to Improve BMI and Lung Function in CF
Status: COMPLETED
Conditions: Cystic Fibrosis|Diabetes Mellitus
Interventions: DRUG: Insulin Asparte|DRUG: Repaglinide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Establish the Relationship Between Shift in Prescribing Pattern and Associated Shift in Sensitivity Pattern of Causative Microbes in UTI Patients in a Closed Community
Status: COMPLETED
Conditions: Uncomplicated Urinary Tract Infection|Antibiotic Resistant Infection
Interventions: DRUG: Tablet Nitrofurantoin|DRUG: Tablet Ciprofloxacin/ Tablet Cefixime/ Tablet Cefuroxime
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Impact on General Functionality of an Immediate Prosthetic Functionalization Protocol in People Over 70 Years of Age With Deficient Removable Prostheses
Status: ACTIVE_NOT_RECRUITING
Conditions: Removable Dental Prosthesis|Dental Restoration|Elderly|Functional Status
Interventions: PROCEDURE: prosthetic refunctioning|PROCEDURE: conventional prosthetic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Women With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Hyperinsulinism
Interventions: DRUG: clomiphene citrate|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Masked Comparison of Bromfenac and Besifloxacin BID With Either Prednisolone BID or Loteprednol 0.5% BID for Prevention of Retinal Thickening and CME Following Phacoemulsification
Status: UNKNOWN
Conditions: Pseudophakia|Cataract Surgery
Interventions: DRUG: Pred Forte|DRUG: Lotemax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Exercise Groups on Patient Mental Health and Wellbeing in an Acute Psychiatric Inpatient Unit
Status: ENROLLING_BY_INVITATION
Conditions: Psychiatric Hospitalization|Physical Inactivity|Depression, Anxiety|Sleep
Interventions: BEHAVIORAL: OT-led Exercise Group|BEHAVIORAL: Treatment as Usual - OT Groups
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Selexipag and Its Metabolite ACT-333679 on Cardiac Repolarization in Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Cardiodynamics|Safety|Tolerability|Pharmacokinetics
Interventions: DRUG: selexipag|DRUG: placebo for selexipag|DRUG: moxifloxacin|DRUG: moxifloxacin-matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Different Doses of Colchicine on hsCRP
Status: COMPLETED
Conditions: Coronary Artery Disease|Percutaneous Coronary Intervention
Interventions: DRUG: Colchicine 0.5 MG|DRUG: Colchicine 0.375 MG|DRUG: Colchicine 0.25 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT