pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Breakfast Intake and Satiety Hormones
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Egg Breakfast (EB)|BEHAVIORAL: Cereal Breakfast (CB)|BEHAVIORAL: Weight Loss Counseling|BEHAVIORAL: Weight Loss Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant and Adjuvant Anti-PD1 or Combinations for Locoregionally Advanced Melanoma
Status: RECRUITING
Conditions: Melanoma Stage III|Melanoma Stage IV|Advanced Melanoma|Melanoma
Interventions: DRUG: Nivolumab|DRUG: Nivolumab + Relatlimab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Pharmacokinetics of Mycophenolate Mofetil in Patients Who Have Undergone Orthotopic Liver Transplantation
Status: COMPLETED
Conditions: Graft Versus Host Disease
Interventions: DRUG: mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The BREASTrial:Breast Reconstruction Evaluation Using Acellular Dermal Matrix as a Sling Trial
Status: COMPLETED
Conditions: Breast Cancer|Reconstructive Surgery
Interventions: PROCEDURE: Implantation of Dermal Matrix substitute
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Colonoscopy, Colon Capsule and Fecal Immunological Test for Colorectal Cancer Screening
Status: RECRUITING
Conditions: Colon Cancer|Rectum Cancer
Interventions: PROCEDURE: optical colonoscopy|PROCEDURE: colon capsule endoscopy|DIAGNOSTIC_TEST: fecal immunological test (FIT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dissemination of Findings Fast Using Online-videos Trial
Status: COMPLETED
Conditions: Information Seeking Behavior
Interventions: OTHER: A short online video with emotional content|OTHER: A short online video with less emotional content
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: IVW-1001 Phase 1/2 in Subjects With Dry Eye Disease
Status: RECRUITING
Conditions: Dry Eye Disease
Interventions: DRUG: IVW-1001 Ophthalmic Eyelid Wipe 0.1%|DRUG: IVW-1001 Ophthalmic Eyelid Wipe 0.2%|DRUG: IVW-1001 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Enlicitide Decanoate in People With Liver Function Problems (MK-0616-030)
Status: NOT_YET_RECRUITING
Conditions: Hepatic Insufficiency|Hepatic Impairment
Interventions: DRUG: Enlicitide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine if BHV-7000 is Effective and Safe in Adults With Idiopathic Generalized Epilepsy With Generalized Tonic-clonic Seizures
Status: RECRUITING
Conditions: Generalized Epilepsy
Interventions: DRUG: BHV-7000|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral Memory Modulation in Nicotine Addiction
Status: ACTIVE_NOT_RECRUITING
Conditions: Nicotine Use Disorder
Interventions: BEHAVIORAL: Retrieval Extinction Training (RET)|BEHAVIORAL: Control Retrieval Extinction Training (RET)|OTHER: Functional magnetic resonance imaging (fMRI)|OTHER: No functional magnetic resonance imaging (fMRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Low Calorie Diet or VLCKD Combined With Physical Training for Preserving Muscle Mass During Weight Loss in Sarcopenic Obesity
Status: COMPLETED
Conditions: Sarcopenic Obesity
Interventions: DIETARY_SUPPLEMENT: meal replacements or supplementation with leucine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double Blind, Placebo Controlled Study to Assess Efficacy of AIN457 in Moderate to Severe Ankylosing Spondylitis
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: BIOLOGICAL: AIN457|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: The Effects of Different Ways of Dressing Central Line Associated Bloodstream Infections
Status: COMPLETED
Conditions: Central Line-associated Bloodstream Infection (CLABSI)
Interventions: OTHER: full aseptic dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase III Trial Assessing the Efficacy and Safety of PXT3003 in CMT1A Patients (PLEO-CMT)
Status: COMPLETED
Conditions: Charcot-Marie-Tooth Disease Type 1A
Interventions: DRUG: PXT3003 dose 1|DRUG: PXT3003 dose 2|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomised Study Evaluating Diagnostics of Pleural Effusion Among Patients Suspect of Cancer.
Status: TERMINATED
Conditions: Pleural Effusion, Malignant|Pleural Effusion|Pleura; Exudate
Interventions: PROCEDURE: Local anesthetic thoracoscopy|PROCEDURE: US-guided pleural biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: CavatermTM vs TCRE in Women With DUB
Status: UNKNOWN
Conditions: Dysfunctional Uterine Bleeding
Interventions: DEVICE: Thermal Balloon Endometrial Ablation|DEVICE: Transcervical Resection of the Endometrium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Severe Influenza Trial of ARbidol
Status: UNKNOWN
Conditions: Influenza
Interventions: DRUG: Arbidol|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Healthy Lifestyle Intervention on Diabetes Risk Reduction Among Bruneian Young Adults
Status: COMPLETED
Conditions: Overweight and Obesity|Risk Reduction|Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Healthy lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: IKS03 in Patients With Advanced B Cell Non-Hodgkin Lymphomas
Status: RECRUITING
Conditions: B-cell Non-Hodgkin Lymphoma|Diffuse Large B Cell Lymphoma|Follicular Lymphoma|Mantle Cell Lymphoma|B-cell Lymphoma
Interventions: DRUG: IKS03
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ME-344 and Bevacizumab in Previously Treated Metastatic Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: ME-344|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduction of Gastrointestinal Toxicity in Prostate Cancer by Proton Spot Placement
Status: RECRUITING
Conditions: Prostate Cancer|Prostate Adenocarcinoma|Prostate Carcinoma
Interventions: RADIATION: Spot Delete planning for proton therapy|RADIATION: Traditional proton treatment planning system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome
Status: UNKNOWN
Conditions: Painful Bladder Syndrome|Interstitial Cystitis|Pelvic Floor; Insufficiency|Bowel Dysfunction|Sexual Dysfunction|Pelvic Floor; Incompetency
Interventions: OTHER: Changing the Interstim parameter of '' Frequency" in patients with Interstitial Cystitis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Almonertinib Combined With or Without Chemotherapy as an Adjuvant Treatment for Stage II-IIIA Non-small Cell Lung Carcinoma Following Complete Tumour Resection
Status: ENROLLING_BY_INVITATION
Conditions: Non-small Cell Lung Carcinoma
Interventions: DRUG: Almonertinib|DRUG: Pemetrexed|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Clinical Stage IV Cutaneous Melanoma AJCC v8|Metastatic Colorectal Carcinoma|Metastatic Malignant Solid Neoplasm|Metastatic Melanoma|Metastatic Ovarian Carcinoma|Metastatic Renal Cell Carcinoma|Platinum-Resistant Ovarian Carcinoma|Recurrent Melanoma|Recurrent Renal Cell Carcinoma|Refractory Melanoma|Refractory Renal Cell Carcinoma|Sarcoma|Stage IV Colorectal Cancer AJCC v8|Stage IV Ovarian Cancer AJCC v8|Stage IV Renal Cell Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Elastography|BIOLOGICAL: Pembrolizumab|BIOLOGICAL: Ziv-Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Utility of Cognitive Behavioral Therapy for Pain Control in Patients With Chronic Pancreatitis
Status: COMPLETED
Conditions: Chronic Pancreatitis
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Does Varenicline Influence Alcohol Consumption in Alcohol Dependent Individuals?
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: varenicline (Champix/Chantix)|DRUG: placebo for varenicline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mobile Media-Rich Interactive Guideline System (MMRIGS) Pilot Study
Status: TERMINATED
Conditions: Tobacco Use Cessation
Interventions: DRUG: Nicotine Patch|BEHAVIORAL: Questionnaires|OTHER: Pamphlet|BEHAVIORAL: Phone Counseling Sessions|OTHER: Saliva Test|DEVICE: Smart phone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media
Status: COMPLETED
Conditions: Diabetes Mellitus|Lactic Acidosis
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effectiveness and Safety of Ultrasound Elastography Guided Pleural Biopsy in the Differential Diagnosis of Benign and Malignant Pleural Effusion
Status: RECRUITING
Conditions: Pleural Effusion
Interventions: PROCEDURE: Ultrasound elastography guided pleural biopsy|PROCEDURE: Traditional ultrasound guided pleural biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Apple Cider Vinegar and Metformin Combination vs Metformin Alone in Type 2 Diabetics
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Metformin Oral Tablet|DIETARY_SUPPLEMENT: Vinegar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MS-SMART: Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial
Status: COMPLETED
Conditions: Secondary Progressive Multiple Sclerosis
Interventions: DRUG: Amiloride|DRUG: Riluzole|DRUG: Fluoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: aSAH Treatment Based on Intraventricular ICP Monitoring: A Prospective, Multicenter, Randomized and Controlled Trial
Status: RECRUITING
Conditions: Aneurysmal Subarachnoid Hemorrhage|Intracranial Pressure Increase
Interventions: DEVICE: Intraventricular intracranial pressure monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Ranibizumab in Patients With Subfoveal Choroidal Neovascularization Secondary to Age-related Macular Degeneration
Status: COMPLETED
Conditions: Subfoveal Choroidal Neovascularization (CNV)|Secondary to Age-related Macular Degeneration (AMD)
Interventions: DRUG: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment
Status: RECRUITING
Conditions: Opioid Use|Pain
Interventions: BEHAVIORAL: MORE|BEHAVIORAL: SMP|OTHER: TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Misoprostol for Induction of Labor in Obese Women: Comparison Between 25 and 50 mcg Oral Administration
Status: RECRUITING
Conditions: Labor, Induced|Obesity|Pregnancy|Cesarean Section
Interventions: DRUG: Misoprostol 25 mcg|DRUG: Misoprostol 50 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Kinesiotaping Versus Wrist Wheel on Upper Extremity Functions in Children With Hemiparetic Cerebral Palsy
Status: UNKNOWN
Conditions: Hemiplegic Cerebral Palsy
Interventions: DEVICE: kinesiotaping|DEVICE: wrist wheel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Asciminib in Monotherapy for Chronic Myeloid Leukemia in Chronic Phase (CML-CP) With and Without T315I Mutation
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia - Chronic Phase
Interventions: DRUG: ABL001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Compare Professional Treatments for Dentinal Hypersensitivity
Status: COMPLETED
Conditions: Dentinal Hypersensitivity
Interventions: DEVICE: Super Seal® Desensitizer|DEVICE: Acclean® Fluoride Varnish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of Augmented Reality During Robot-assisted Radical Prostatectomy
Status: RECRUITING
Conditions: Prostatic Neoplasm
Interventions: PROCEDURE: Augmented reality robot-assited radical prostatectomy|DEVICE: Mixed reality intraoperative frozen section analysis|PROCEDURE: Robot-assited radical prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Addition of Metformin to Definitive Radiotherapy in Patients With Stage III NSCLC
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Metformin|OTHER: No metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A New Wizard for Insulin Sensitivity Estimation From SAP: a Randomized Controlled Trial in Adolescents With T1D
Status: WITHDRAWN
Conditions: Diabetes Mellitus
Interventions: OTHER: individualized insulin sensitivity index (ISind)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Camrelizumab in Combination With Apatinib in Refractory and Relapsed DLBCL
Status: UNKNOWN
Conditions: Diffuse Large B Cell Lymphoma|High-grade B-cell Lymphoma|Follicular Lymphoma Grade IIIb|Transformed Lymphoma|EBV-Positive DLBCL, Nos|ALK-Positive Anaplastic Large Cell Lymphoma
Interventions: DRUG: Camrelizumab|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Oral Supplementation of Probiotics in Children With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Probiotic sachet containing mixture of four strains i.e.Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium longum, and Saccharomyces boulardii|DRUG: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of MabThera/Rituxan (Rituximab) in Patients With Follicular Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: rituximab [MabThera/Rituxan]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effect of Intravitreal Injection of a Derivative of Nucleoside Reverse Transcriptase Inhibitor in Subjects With Diabetic Macular Edema
Status: RECRUITING
Conditions: Diabetic Macular Edema
Interventions: DRUG: K8
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Topical Vitamin D and Supplementation In Acne Vulgaris The Study of VDR, IL-1β, IL-6, IL-10 and IL-17 Expression
Status: ENROLLING_BY_INVITATION
Conditions: Acne Vulgaris|Vitamin D
Interventions: DRUG: combination oral and topical vitamin D|DRUG: oral placebo and topical cholecalciferol|DRUG: oral placebo and basic ingredient placebo topical vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 99mTc-DARPinG3-based HER2 Expression Molecular Imaging in HER2-positive Breast Cancer During Chemo+Targeted Therapy
Status: COMPLETED
Conditions: HER2-positive Breast Cancer|Female
Interventions: DRUG: 99mTc-DARPinG3
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized, Double-blind, Placebo-controlled Phase IIa Clinical Study to Evaluate the Safety and Efficacy of GST-HG131 Tablets in Patients With Chronic Hepatitis B
Status: RECRUITING
Conditions: Chronic Hepatitis B
Interventions: DRUG: GST-HG131|DRUG: Placebo to match GST-HG131
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Abuse Potential of 3 Doses of GRT6005 in Adult Non-dependent Recreational Opioid Users
Status: COMPLETED
Conditions: Abuse, Drug
Interventions: DRUG: Cebranopadol 100 micrograms|DRUG: Cebranopadol 400 micrograms|DRUG: Hydromorphone hydrochloride 4 milligrams|DRUG: Placebo matching hydromorphone|DRUG: Placebo matching cebranopadol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dermal Irritation, Sensitization and Cumulative Irritation Potential of 6% Bemotrizinol
Status: COMPLETED
Conditions: Sunburn
Interventions: DRUG: 6% Bemotrizinol (BEMT) in a basic sunscreen oil formulation|DRUG: 6% Bemotrizinol (BEMT) dispersion in petrolatum|OTHER: Sunscreen oil vehicle with 10% ethanol as penetration enhancer without BEMT|OTHER: Petrolatum vehicle|OTHER: 0.9% Saline|OTHER: Sodium Lauryl Sulfate 0.1% (SLS)|OTHER: Undosed patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: When to INDuce for OverWeight? (WINDOW)
Status: RECRUITING
Conditions: Pregnancy|Obesity|Parturition
Interventions: PROCEDURE: Elective induction of labor at 39 gestational weeks and 0 to 3 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib and Topotecan Hydrochloride in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: bortezomib|DRUG: topotecan hydrochloride|OTHER: immunohistochemistry staining method|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Small Bowel Healing in Crohn's Disease Patients Treated With Cimzia Using Wireless Capsule Endoscopy
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: certolizumab pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Describe the Safety of a Vaccine (Called 13vPnC) in Healthy People 18 to 49 Years of Age in India
Status: COMPLETED
Conditions: Pneumococcal Disease
Interventions: BIOLOGICAL: 13-valent pneumococcal conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Docetaxel, Cisplatin, Pegfilgrastim, and Erlotinib Hydrochloride in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Lung|Adenosquamous Cell Lung Cancer|Bronchoalveolar Cell Lung Cancer|Large Cell Lung Cancer|Non-small Cell Lung Cancer|Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: DRUG: cisplatin|BIOLOGICAL: pegfilgrastim|DRUG: erlotinib hydrochloride|OTHER: laboratory biomarker analysis|GENETIC: polymorphism analysis|OTHER: pharmacogenomic studies|GENETIC: genetic linkage analysis|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk Stratification Procedure for Thromboembolism Prophylaxis
Status: COMPLETED
Conditions: Total Knee Replacement Surgeries
Interventions: DRUG: acetylsalicylic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Repetitive Transcranial Magnetic Stimulation and Cognitive Behavioral Therapy on Heroin Dependence
Status: UNKNOWN
Conditions: Heroin Dependence
Interventions: COMBINATION_PRODUCT: Transcranial magnetic stimulation and Cognitive behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mometasone Furoate in Preventing Radiation Dermatitis in Patients Undergoing Radiation Therapy to the Breast or Chest Wall for Invasive Breast Cancer or Ductal Carcinoma in Situ
Status: COMPLETED
Conditions: Breast Cancer|Dermatologic Complications|Radiation Toxicity|Skin Reactions Secondary to Radiation Therapy
Interventions: DRUG: mometasone furoate|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Perioperative Lidocaine on Gastrointestinal Function Recovery After Lumbar Spine Surgery in Adults
Status: UNKNOWN
Conditions: Spinal Surgery|Lidocaine|Pain|Opioid Consumption|Gastrointestinal Dysfunction
Interventions: DRUG: Lidocain|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Comparative Pharmacokinetic and Pharmacodynamic Study of Sildenafil in Adult Smokers and Non Smokers
Status: COMPLETED
Conditions: Erectile Dysfunction|Smoking|Pharmacokinetics|Pharmacodynamics
Interventions: DRUG: Sildenafil 50 mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PORCINE XENOGRAFT OR MICROBIAL CELLULOSE IN THE TREATMENT OF PARTIAL THICKNESS BURNS
Status: COMPLETED
Conditions: Burns|Burn Scar|Burn Second Degree
Interventions: OTHER: microbial cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: On-Q Pump vs Epidural for Postoperative Pain Control in Children
Status: TERMINATED
Conditions: Postoperative Pain
Interventions: DEVICE: On-Q pump|DEVICE: Epidural catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low Carbohydrate Diet Compared to Calorie and Fat Restricted Diet in Patients With Obesity and Type II Diabetes
Status: COMPLETED
Conditions: Obesity|Type 2 Diabetes|Hyperlipidemia
Interventions: BEHAVIORAL: Low Carbohydrate Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Preemptive Regional Anesthesia (TAP-block) on Acute and Chronic Pain After Transabdominal Preperitoneal Inguinal Hernia Repair (TAPP)
Status: RECRUITING
Conditions: Primary Inguinal Hernia
Interventions: PROCEDURE: Transversus abdominal plane block (TAP block)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Assessment of the Full Range of Functional Vision With Three Tecnis Multifocal IOL 1-Piece Models in Bilateral Cataract Extraction
Status: UNKNOWN
Conditions: Cataract
Interventions: DEVICE: Tecnis Multifocal 1-Piece IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Value of Pulse Pressure Variations and Corrected Flow Time in Esophageal Doppler as a Predictor of Fluid Responsiveness in Prone Position During Spinal Surgery
Status: COMPLETED
Conditions: Elective Posterior Lumbar Spinal Fusion
Interventions: DEVICE: 1.Esophageal doppler monitor|DEVICE: 2. philips Intelivue MP70 monitors
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Extraneal (Icodextrin) on Triglyceride Levels in PD Patients
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DRUG: Extraneal (Icodextrin)|DRUG: Glucose solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgery Prevention by Transforaminal Injection of Epidural Steroids for Cervical Radicular Pain
Status: SUSPENDED
Conditions: Pain, Radiating
Interventions: DRUG: Lidocaine|DRUG: Lidocaine with Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: STAMP: Sharing and Talking About My Preferences
Status: COMPLETED
Conditions: Advanced Care Planning (ACP)
Interventions: BEHAVIORAL: Transtheoretical Model (TTM) of health behavior change|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Complementary Interventions on Patients With Dementia: Comparative and Longitudinal Research
Status: COMPLETED
Conditions: Dementia
Interventions: BEHAVIORAL: Reminiscence|BEHAVIORAL: Cognitive stimulation|BEHAVIORAL: Aroma-massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Relief of Lumbar Spinal Stenosis Symptoms
Status: RECRUITING
Conditions: Spinal Stenosis Lumbar|Low Back Pain
Interventions: PROCEDURE: Caudal epidural pulsed radiofrequency|PROCEDURE: Caudal epidural steroid enjection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Single Dose Ketamine and Magnesium on Postoperative Pain in Patients Undergoing Bariatric Surgery
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Ketamine|DRUG: Ketamine plus magnesium|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Psychological Treatment of Overweight Binge Eaters Minority Supplement
Status: COMPLETED
Conditions: Binge Eating Disorder|Cognitive Therapy/Methods|Mental Disorders/Epidemiology|Obesity/Epidemiology|Obesity/Therapy
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy (CBT)|BEHAVIORAL: Interpersonal Therapy (IPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intracolonic Vancomycin Therapy in Severe C. Diff Colitis
Status: TERMINATED
Conditions: Colitis
Interventions: DRUG: Vancomycin|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Trial of a Multimodal Lifestyle Intervention to Optimize Survivorship After Cancer
Status: RECRUITING
Conditions: Neoplasm Malignant
Interventions: BEHAVIORAL: Multimodal Lifestyle Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dimethyl Fumarate Treatment for Intracranial Unruptured Aneurysms.
Status: NOT_YET_RECRUITING
Conditions: Intracranial Aneurysm|Aneurysm, Brain|Inflammation Vascular
Interventions: DRUG: Dimethyl fumarate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Titrated Oral Tolvaptan 15-60 mg Once Daily (QD) on Cognitive and Neurological Function in Elderly Hyponatremic Patients
Status: COMPLETED
Conditions: Hyponatremia
Interventions: DRUG: Tolvaptan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hematopoietic Stem Cell Transplant for High Risk Hemoglobinopathies
Status: RECRUITING
Conditions: Sickle Cell Disease|Transfusion Dependent Alpha- or Beta- Thalassemia|Diamond Blackfan Anemia|Paroxysmal Nocturnal Hemoglobinuria|Glanzmann Thrombasthenia|Severe Congenital Neutropenia|Shwachman-Diamond Syndrome|Non-Malignant Hematologic Disorders
Interventions: DRUG: Reduced Toxicity Ablative Regimen|DRUG: Reduced Intensity Preparative Regimen|DRUG: Myeloablative Preparative Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dual-task Assessment and Rehabilitation for Individuals With Residual Symptoms After mTBI
Status: COMPLETED
Conditions: Brain Injury Traumatic Mild|Concussion, Brain
Interventions: BEHAVIORAL: Cognitive and Motor Dual-task Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Motor Imagery and Task-oriented Training in Children With Developmental Coordination Disorder
Status: ACTIVE_NOT_RECRUITING
Conditions: Developmental Coordination Disorder
Interventions: OTHER: MOTOR IMAGERY AND TASK-ORIENTED TRAINING
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between the Effect of Infiltration Between the Popliteal Artery and Capsule of the Knee Block Versus Selective Tibial Nerve Block for Postoperative Analgesia in Patient Undergoing Total Knee Arthroplasty. A Prospective Randomized Study
Status: COMPLETED
Conditions: Postoperative Analgesia
Interventions: PROCEDURE: Adductor canal block with Ipack block or selective tibial nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 1b/2, Open Label, Repeat Dose, Dose Escalation Study of ND-L02-s0201 Injection in Subjects With Moderate to Extensive Fibrosis (METAVIR F3-4)
Status: COMPLETED
Conditions: Moderate to Extensive Hepatic Fibrosis (METAVIR F3-4)
Interventions: DRUG: ND-L02-s0201 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Combination of Bortezomib/Dexamethasone/Zoledronic Acid on Bone Disease in Patients With Multiple Myeloma Relapsed After 1-3 Prior Lines of Therapy
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib|DRUG: Zoledronic Acid|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacological Mechanisms of Low-intensity Focused Ultrasound for Motor Cortex Neuroplasticity
Status: RECRUITING
Conditions: Low Intensity Focussed Ultrasound
Interventions: DRUG: Carbamazepine|DRUG: Lorazepam|DRUG: Dextromethorphan|DRUG: Nimodipine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Exercise in Improving Health and Quality of Life in Breast Cancer Survivors
Status: COMPLETED
Conditions: Invasive Breast Carcinoma
Interventions: OTHER: Best Practice|BEHAVIORAL: Exercise Intervention (home walking program and resistance training)|BEHAVIORAL: Exercise Intervention (home-based Zumba program and resistance training)|BEHAVIORAL: Exercise Intervention (HIIT program and resistance training)|OTHER: Informational Intervention|OTHER: Laboratory Biomarker Analysis|DEVICE: Monitoring Device|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Liposomal siRNA in Subjects With High Cholesterol
Status: TERMINATED
Conditions: Hypercholesterolemia
Interventions: DRUG: PRO-040201|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Whether a Medication Event Monitoring System (MEMS) Can Improve Adherence to Tecfidera Treatment in Multiple Sclerosis Patients.
Status: TERMINATED
Conditions: Multiple Sclerosis
Interventions: DRUG: dimethyl fumarate|DEVICE: Medication Event Monitoring System (MEMS)|BEHAVIORAL: Adherence counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Trial of Desmopressin Orally Disintegrating Tablets (ODT) for Nocturia Due to Nocturnal Polyuria in Japanese Male Subjects
Status: COMPLETED
Conditions: Nocturia
Interventions: DRUG: Desmopressin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sublingual Cannabidiol for Anxiety
Status: RECRUITING
Conditions: Anxiety
Interventions: DRUG: Full-Spectrum Cannabidiol|DRUG: Single-Compound Cannabidiol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Donafenib Plus S-1 in Treating Patients With Metastatic Pancreatic Cancer After Chemotherapy With Nab-paclitaxel Plus Gemcitabine Regimen
Status: UNKNOWN
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: Donafenib|DRUG: S1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Adding Apalutamide to Radiotherapy and LHRH Agonist in High-Risk Patients With Hormone-Sensitive Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostatic Neoplasms
Interventions: RADIATION: Radiotherapy|DRUG: LHRHa|DRUG: Apalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Barbed Versus PGA Sutures in Minimally Invasive Dismembered Pyeloplasty
Status: RECRUITING
Conditions: Pelvi-Ureteric Obstruction
Interventions: DEVICE: Barbed suture|DEVICE: PGA suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of SIM0501 Alone and in Combination in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: SIM0501 Tablets|DRUG: SIM0501 Tablets|DRUG: SIM0501 in combination with olaparib|DRUG: SIM0501 in combination with olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Evaluating Nicotine Lozenges and Self Help
Status: COMPLETED
Conditions: Smokeless Tobacco Use
Interventions: DRUG: nicotine replacement therapy|DRUG: placebo NRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IMPROVE-DiCE: Study to Evaluate Effect of IMB-1018972 on Cardiac Energetics in T2DM & Obesity (Pt 1) With HFpEF (Pt 2)
Status: RECRUITING
Conditions: Type 2 Diabetes|Diabetic Cardiomyopathies|HFpEF - Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: IMB-1018972
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin for Older Patients With Heart Failure With Preserved Ejection Fraction
Status: RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Health Management of Glycemic Control and Physical Activity in Type 2 Diabetes Mellitus Using Smartphone Application
Status: UNKNOWN
Conditions: To Investigate the Effectiveness of Health Management of Glycemic Control and Physical Activity in Type 2 Diabetes Mellitus Using Smartphone Application
Interventions: BEHAVIORAL: Health2Sync app and report blood glucose data weekly|OTHER: self-manage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: First-in-human Study of OT-A201 in Patients With Selected Hematological Malignancies and Solid Tumors
Status: RECRUITING
Conditions: Hematological Malignancy|Solid Tumor
Interventions: DRUG: OT-A201|DRUG: IMids|DRUG: Bevacizumab|DRUG: Paclitaxel|DRUG: TBD Compound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nab-paclitaxel and Carboplatin Followed by Response-Based Local Therapy in Treating Patients With Stage III or IV HPV-Related Oropharyngeal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Human Papilloma Virus Infection|Stage III Squamous Cell Carcinoma of the Oropharynx|Stage IVA Squamous Cell Carcinoma of the Oropharynx|Stage IVB Squamous Cell Carcinoma of the Oropharynx
Interventions: DRUG: paclitaxel albumin-stabilized nanoparticle formulation|DRUG: carboplatin|RADIATION: radiation therapy|DRUG: paclitaxel|DRUG: fluorouracil|DRUG: hydroxyurea|DRUG: cisplatin|OTHER: laboratory biomarker analysis|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Eribulin in Patients Who Do Not Achieve Pathologic Complete Response (pCR) Following Neoadjuvant Chemotherapy
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Eribulin|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of PRF and MTA as Compared to Calcium Hydroxide for Pulpotomy in Human Irreversibly Inflamed Permanent Teeth
Status: COMPLETED
Conditions: Pulpitis - Irreversible|Tooth Decay
Interventions: OTHER: Calcium hydroxide|OTHER: MTA|OTHER: PRF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of BMN053 in Subjects With Duchenne Muscular Dystrophy (DMD)
Status: TERMINATED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: Regimen Selection Phase Group 2|DRUG: Regimen Selection Phase Group 3|DRUG: Treatment Phase Group 4|DRUG: Regimen Selection Phase Group 1 (COMPLETED)|DRUG: Dosing Extension
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of DE-111A on the Treatment of Open Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-angle Glaucoma, Ocular Hypertension
Interventions: DRUG: A preservative-free, a clear, colorless sterile aqueous ophthalmic solution containing 0.015mg of tafluprost and 5.0mg of timolol in 1mL|DRUG: A preservative-free, a clear, colorless sterile aqueous ophthalmic solution containing 0.015mg of tafluprost in 1mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Synbiotics Supplement on Biochemical Factors and Hepatic Fibrosis in Patients With Nonalcoholic Steatohepatitis
Status: COMPLETED
Conditions: Non Alcoholic Steatohepatitis
Interventions: DIETARY_SUPPLEMENT: synbiotic|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Light Therapy as Treatment for Fatigue in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DEVICE: Light Therapy box
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PROACTIVE-HF IDE Trial Heart Failure NYHA Class III
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure NYHA Class III
Interventions: DEVICE: Cordella™ Pulmonary Artery Sensor System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: TVTO™ X TVTS ™ for Treatment of Stress Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: TVT-O|DEVICE: TVT-S
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgery Plus Radiation Therapy With or Without Chemotherapy in Treating Children With Primitive Neuroectodermal Tumors of the CNS
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: vincristine sulfate|PROCEDURE: surgical procedure|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Sun Protection Factor (SPF) Determination of Two Sunscreen-Containing Lip Balms
Status: COMPLETED
Conditions: Sunscreening Agents
Interventions: DRUG: ChapStick Moisturizer, Strawberry Flavor|DRUG: ChapStick Moisturizer, Classic Flavor|DRUG: ISO 24444:2010 P2 Standard Reference Sunscreen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Conventional and Pulsating Toothbrushes on Mentally Disabled Children
Status: COMPLETED
Conditions: Periodontal Indexes
Interventions: DEVICE: Conventional Toothbrushes|DEVICE: Pulsating Toothbrushes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of DISCOVER™ Artificial Cervical Disc and ACDF for Treatment of Cervical DDD (IDE Study)
Status: COMPLETED
Conditions: Cervical Degenerative Disc Disease
Interventions: DEVICE: Cervical TDR|DEVICE: ACDF with plate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Extracorporeal Shockwave Therapy Combined With Platelet-rich Plasma in the Treatment of Chronic Insertional Achilles Tendinopathy
Status: NOT_YET_RECRUITING
Conditions: Insertional Achilles Tendinopathy
Interventions: DEVICE: ESWT|BIOLOGICAL: PRP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT