pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Longitudinal Studies of the Glycoproteinoses
Status: COMPLETED
Conditions: Aspartylglucosaminuria|Fucosidosis|Galactosialidosis|Alpha Mannosidosis|Beta Mannosidosis|Mucolipidosis II|Mucolipidosis III|Schindler Disease|Sialidosis
Interventions: OTHER: Non-interventional.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Using Advanced Data Systems to Improve Health in Early Life in Rural Nepal
Status: NOT_YET_RECRUITING
Conditions: Maternal Health|Infant Health|Institutional Delivery|Birth Preparedness and Complication Readiness|Severe Maternal Morbidity|Neonatal Adverse Outcome
Interventions: OTHER: Mobile Phone and Cloud-based Electronic Contact and Recording System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Transition of Inflammatory Bowel Disease (IBD) Patients From Pediatric to Adult Gastroenterologist (GI)
Status: TERMINATED
Conditions: Inflammatory Bowel Diseases|Crohn's Disease|Ulcerative Colitis
Interventions: OTHER: Joint visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Soins intégrés BPCO (Broncho-pneumopathie Chronique Obstructive) en Valais - Mieux Vivre Avec ma BPCO (COPD Integrated Care Program Valais - Living Well With COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: OTHER: COPD integrated care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Dasatinib, Bevacizumab, Paclitaxel in Patients With Advanced Malignancies
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: DRUG: Dasatinib|DRUG: Bevacizumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Place of 68Ga-PSMA-11 PET-CT in the Therapeutic Decision at the End of the Initial Staging for High Risk Prostate Cancer Patients
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: 68Ga-PSMA-11|DIAGNOSTIC_TEST: 18F-Choline PET-CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Skin as a Window to the Central Nervous System in Frontotempolar Lombar Degeneration
Status: NOT_YET_RECRUITING
Conditions: Frontotemporal Lobar Degeneration
Interventions: PROCEDURE: Skin biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dupilumab in the Treatment of Keloids
Status: ACTIVE_NOT_RECRUITING
Conditions: Keloid
Interventions: DRUG: Dupilumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Vitamin D3 Supplementation in Paediatric Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: VItamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Long-term Safety Study of Alogliptin Used in Combination With Thiazolidine in Participants With Type 2 Diabetes in Japan
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Alogliptin and pioglitazone|DRUG: Alogliptin and pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Incidence and Outcomes of Metabolically Active Brown Adipose Tissue (aBAT) in Patients With Pheochromocytoma or Paraganglioma (PPGLs)
Status: RECRUITING
Conditions: Pheochromocytoma|Paraganglioma
Interventions: DIAGNOSTIC_TEST: FDG-PET Scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Strategies for Delivering Anti-HIV Therapy in South Africa
Status: COMPLETED
Conditions: HIV Infections
Interventions: BEHAVIORAL: Monitoring by HIV-trained primary care nurses|BEHAVIORAL: Community-based directly observed therapy (DOT)|DRUG: stavudine|DRUG: lamivudine|DRUG: efavirenz|DRUG: zidovudine|DRUG: didanosine|DRUG: lopinavir/ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stone Clearance in Patients With Upper Ureteric Stones Using Extracorporeal Shock Wave Lithotripsy Compared With Extracorporeal Shock Wave Lithotripsy Combined With Tamsulosin Therapy
Status: COMPLETED
Conditions: Renal Stone
Interventions: PROCEDURE: Extracorporeal shock wave lithotripsy|PROCEDURE: Extracorporeal Shock Wave Lithotripsy combined with Tamsulosin Therapy.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neo-adjuvant Therapy and the Effect on Synchronous Metastatic Growth
Status: UNKNOWN
Conditions: Colorectal Neoplasms|Liver Neoplasms
Interventions: PROCEDURE: immediate surgery (resection of primary colorectal tumor)|DRUG: neo-adjuvant treatment with bevacizumab|DRUG: neoadjuvant treatment with capecitabine and oxaliplatin|DRUG: neo-adjuvant treatment with bevacizumab, capecitabine and oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dual-Energy Computed Tomography (DECT) in Acute Neck Infections: Comparison With Magnetic Resonance Imaging (MRI)
Status: RECRUITING
Conditions: Neck Abscess
Interventions: DIAGNOSTIC_TEST: Dual-energy CT|DIAGNOSTIC_TEST: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ph1b/2 Study of the Safety and Efficacy of SHR-A1811 Combinations in Advanced HER2+ Gastric Cancer
Status: RECRUITING
Conditions: HER2+ Gastric Cancer/Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: SHR-A1811；SHR-1701；capecitabine；oxaliplatin|DRUG: SHR-A1811；SHR-1701；capecitabine；oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Olmesartan Associated With Chlorthalidone in Essential Arterial Hypertension Control
Status: NOT_YET_RECRUITING
Conditions: Essential Arterial Hypertension
Interventions: DRUG: Olmesartan Medoxomil 20mg + Chlorthalidone 12,5mg|DRUG: Olmesartan medoxomil 20mg + Chlortalidone 25mg|DRUG: Olmesartan 20mg + hydrochlorothiazide 12,5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Augmented Reality Serious Game Design for Promoting Children's Science Education Cognition
Status: COMPLETED
Conditions: Educational Problems|Augmented Reality|Serious Game
Interventions: COMBINATION_PRODUCT: Augmented reality serious game design for promoting children's science education cognition:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Establishment and Preliminary Evaluation of Digital Three Level Linkage Whole Process Diabetes Management System
Status: UNKNOWN
Conditions: Diabetes Mellitus
Interventions: BEHAVIORAL: Traditional mode of management|BEHAVIORAL: Mobile APP management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Added Value of 18 FDG Pet-scanner in Diagnosis and Management of Subclinical Rejection in Kidney Transplant Patients
Status: RECRUITING
Conditions: Kidney Transplant Rejection|Kidney Transplant; Complications
Interventions: DIAGNOSTIC_TEST: 18FDG PET / CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Facilitated Tucking During Pain Procedure in Preterm Infants
Status: COMPLETED
Conditions: Facilitated Tucking|Non Nutritive Sucking|Preterm|Pain Relief
Interventions: BEHAVIORAL: Facilitated tucking + non-nutritive sucking|OTHER: non-nutritive sucking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Eight-week Study of Saredutant and Escitalopram as Combination Treatment for Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: saredutant (SR48968)|DRUG: escitalopram|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of TG103 Injection in Type 2 Diabetes Subjects
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: TG103,Q2W|DRUG: TG103,QW|DRUG: Placebo,Q2W|DRUG: Placebo,QW|DRUG: Dulaglutide,QW
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact on Daily Life of Patients Using the Subretinal Implant RETINA IMPLANT Alpha AMS
Status: TERMINATED
Conditions: Retinal Degeneration|Inherited Retinal Dystrophy Primarily Involving Sensory Retina
Interventions: DEVICE: RETINA IMPLANT Alpha AMS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2A Pilot C3 Trial of Recurrent/Refractory Metastatic Advanced Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer Metastatic
Interventions: DRUG: Gemcitabine and C3 (Metformin, Simvastatin, and Digoxin)|DRUG: C3 (Metformin, Simvastatin, and Digoxin) only
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Tolerability Study of Levalbuterol HFA Compared to Racemic Albuterol HFA in Subjects With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Levalbuterol HFA MDI followed by Racemic albuterol HFA MDI|DRUG: Racemic Albuterol followed by levalbuterol HFA MDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Adjuvant Therapy by Sorafenib, Oxaliplatin and S-1
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Sorafenib|DRUG: S-1|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CSE-1034 (Ceftriaxone+ Sulbactam+ EDTA) Compared to Meropenem in Complicated Urinary Tract Infections (cUTIs) Caused by ESBL Producing Gram Negative Bacteria
Status: COMPLETED
Conditions: Urinary Tract Infection Complicated|Acute Pyelonephritis
Interventions: DRUG: CSE-1034 (Ceftriaxone + Sulbactam + EDTA)|DRUG: Meropenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Central Sodium Sensing: Implications for Blood Pressure Regulation
Status: RECRUITING
Conditions: Salt Sensitivity of Blood Pressure
Interventions: OTHER: Dietary Intervention|OTHER: Hypertonic Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Single Dose Study Investigating the Elimination as Well as the Tolerability of PD 0332334 in Healthy Subjects as Compared to Patients With Impaired Kidney Function.
Status: TERMINATED
Conditions: Renal Insufficiency|Pharmacokinetics
Interventions: DRUG: PD 0332334|DRUG: PD 0332334|DRUG: PD 0332334|DRUG: PD 0332334
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Changing Thought and Action in Tobacco Dependence With Transcranial Magnetic Stimulation
Status: COMPLETED
Conditions: Tobacco Dependence
Interventions: DEVICE: repetitive transcranial magnetic stimulation (rTMS) 10 Hertz (Hz)|DEVICE: repetitive transcranial magnetic stimulation (rTMS) 20Hz|DEVICE: SHAM repetitive transcranial magnetic stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Galvus as add-on Therapy to Metformin Plus Glimepiride
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Vildagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relatlimab With Nivolumab and 5-Azacytidine for the Treatment of AML
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine Injection|DRUG: Nivolumab|DRUG: Relatlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Granulosa Cells Function After IVF Protocols
Status: UNKNOWN
Conditions: Infertility|In Vitro Fertilization Protocols
Interventions: DRUG: randomization between the two GnRH analogues (agonist and antagonist)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: DiviTum®TKa: A Biomarker Assay for Efficacy in HR+ Metastatic Breast Cancer Patients
Status: RECRUITING
Conditions: HER2-negative Breast Cancer|Hormone-receptor-positive Breast Cancer|Metastatic Breast Cancer
Interventions: PROCEDURE: Biospecimen Collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Norepinephrine Infusion Versus Midodrine & Octreotide in Patients With Hepatorenal Syndrome Type 1.
Status: COMPLETED
Conditions: Renal Impairment in Hepatorenal Syndrome
Interventions: DRUG: norepinephrine versus midodrine & octreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Efficacy of LightWalker (Nd:Yag, Er:Yag) Laser Therapy on Incidence, Severity and Duration of Oral Mucositis in Patients Undergoing Hematopoietic Stem Cell Transplantation (HSCT). Prospective Randomized Open-label Study
Status: COMPLETED
Conditions: Oral Mucositis|Bone Marrow Transplant Complications
Interventions: RADIATION: Laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of GLP-1 on Microvascular Insulin Responses in Type 1 Diabetes
Status: WITHDRAWN
Conditions: Type 1 Diabetes|Insulin Sensitivity/Resistance
Interventions: DRUG: GLP-1|DRUG: Insulin|DRUG: Dextrose 20 % in Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Adjunctive Right Atrial Ablation for Persistent Atrial Fibrillation
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation, Persistent
Interventions: PROCEDURE: Catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of the Combination of VX-222 and Telaprevir in Treatment-Naïve Subjects With Genotype 1 Chronic Hepatitis C Virus Infection
Status: TERMINATED
Conditions: Chronic Hepatitis C Virus Infection
Interventions: DRUG: telaprevir|DRUG: VX-222|DRUG: ribavirin|BIOLOGICAL: peginterferon-alfa-2a|DRUG: VX-222
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Change in Taste Sensation After Orthognathic Surgery
Status: COMPLETED
Conditions: Orthognathic Surgery|Altered Taste
Interventions: DIAGNOSTIC_TEST: Whole mouth taste tests|DIAGNOSTIC_TEST: Localized taste tests
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: FCR or BR in Patients With Previously Untreated B-Cell Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: Rituximab|DRUG: Bendamustine|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Melphalan+Bortezomib as a Conditioning Regimen for Autologous and Allogeneic Stem Cell Transplants in Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib|DRUG: Melphalan|PROCEDURE: Autologous Stem Cell Transplant|DRUG: Fludarabine|PROCEDURE: Allogeneic Stem Cell Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Dose Bioequivalence Study of WD-1602 Versus Pradaxa® in Healthy Subjects Under Fed Condition
Status: UNKNOWN
Conditions: Anticoagulant
Interventions: DRUG: WD-1602|DRUG: Pradaxa®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical 0.05% Clobetasol Propionate in Vaseline Versus UVA-1 Phototherapy in Vulvar Lichen Sclerosus
Status: COMPLETED
Conditions: Vulvar Lichen Sclerosus
Interventions: OTHER: UVA1 phototherapy|OTHER: Cortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postcath Radial Arterial Clamp Time In the CAth Lab
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Vascular compression device- RADAR TM-Short clamp time|DEVICE: Vascular compression device RADAR TM-Long clamp time
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Activity Augmentation Using Pedometers During Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Lung Diseases, Obstructive|Pulmonary Disease, Chronic Obstructive|Bronchitis, Chronic
Interventions: DEVICE: Yamax Digi-Walker CW-700
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A First-in-Human Study of QY211 Gel in Adult Subjects
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: 0.1% QY211 Gel or placebo|DRUG: 0.3% QY211 Gel or placebo|DRUG: 0.8% QY211 Gel or placebo|DRUG: 1.5% QY211 Gel or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Long-term Safety and Tolerability of Brivaracetam in Study Participants With Childhood Absence Epilepsy or Juvenile Absence Epilepsy
Status: RECRUITING
Conditions: Childhood Absence Epilepsy|Juvenile Absence Epilepsy
Interventions: DRUG: Brivaracetam Film-coated tablet|DRUG: Brivaracetam oral solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Evaluation of Moxifloxacin Administered Intravenously and Orally in Healthy Volunteers Who Have Had a Gastric Bypass
Status: COMPLETED
Conditions: Gastric Bypass|Body Weight
Interventions: DRUG: moxifloxacin per IV|DRUG: moxifloxacin per os
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Markers for Chronic Obstructive Pulmonary Disease (COPD)
Status: WITHDRAWN
Conditions: Healthy Non-smokers|Current Smokers|COPD Patients
Interventions: PROCEDURE: Spirometry|PROCEDURE: Exhaled Nitric Oxide and Carbon Monoxide|PROCEDURE: Exhaled Breath Condensate|PROCEDURE: Induced Sputum|PROCEDURE: CT Scan|PROCEDURE: Blood test|PROCEDURE: St Georges Questionnaire|PROCEDURE: Bodypletysmography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Pitavastatin on Coronary Flow Reserve in Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension|Cardiovascular Risk
Interventions: DRUG: Pitavastatin|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Opioid Safety in Veterans Using Collaborative Care and Decision Support
Status: COMPLETED
Conditions: Chronic Pain
Interventions: BEHAVIORAL: Motivational Interviewing|BEHAVIORAL: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Chronic Low Back Pain Exercise Therapies With Cerebral Electrical Stimulation
Status: COMPLETED
Conditions: Low Back Pain, Recurrent|Chronic Low Back Pain
Interventions: PROCEDURE: Real transcranial direct current stimulation + therapeutic exercises for back pain|PROCEDURE: Sham transcranial direct current stimulation + therapeutic exercises for back pain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Photobiomodulation on the Salivary Glands of Patients With Xerostomia Induced by the Use of Benzodiazepines
Status: UNKNOWN
Conditions: Xerostomia
Interventions: RADIATION: Photobiomodulation|RADIATION: Simulation of Photobiomodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Collagen Matrix + rhPDGF-BB vs Connective Tissue Graft for the Treatment of Peri-implant Soft Tissue Dehiscences
Status: RECRUITING
Conditions: Implant Complication
Interventions: OTHER: Prosthetic-surgical approach + autogenous graft|OTHER: Prosthetic-surgical approach + graft substitute
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Abiraterone Acetate Plus Prednisone in Patients With Chemo-naive Metastatic Castration-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Placebo and prednisone|DRUG: Abiraterone acetate and prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risk of Developing Dementia and Associated Factors in Patients With Normal Brain FDG PET
Status: COMPLETED
Conditions: Neurodegenerative Diseases|Cognitive Disorder
Interventions: DEVICE: 18F-FDG PET-CT (fluorodesoxyglucose positron emission tomography)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of ARC-521 Injection in Normal Adult Volunteers and Patients With Chronic Hepatitis B (CHB)
Status: TERMINATED
Conditions: Hepatitis B
Interventions: DRUG: ARC-521 Injection|OTHER: Placebo|DRUG: antihistamine|DRUG: acetaminophen|DRUG: entecavir|DRUG: tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Ultrasound for Focal Neuropathies
Status: COMPLETED
Conditions: Focal Neuropathies|Carpal Tunnel Syndrome|Cubital Tunnel Syndrome|Median Neuropathy|Ulnar Neuropathy|Peroneal Neuropathy|Radial Neuropathy|Sciatic Neuropathy|Tibial Neuropathy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluate the Effectiveness of an Experimental Urethane Dimethacrylate Resin Based Dental Composite Material
Status: COMPLETED
Conditions: Dental Caries|Restorative Material
Interventions: DEVICE: urethane dimethacrylate|DEVICE: TPH3|DEVICE: Esthet-X HD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Usefulness of the Artery First Approach in Pancreatic Cancer Surgery
Status: UNKNOWN
Conditions: Pancreatic Cancer, Adult|Margin, Tumor-Free|Surgery Site Fistula|Recurrence Tumor
Interventions: PROCEDURE: conventional pancreaticoduodenectomy|PROCEDURE: total mesopancreas excision including superior mesenteric artery first approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Loop Ileostomy Closure as a 23-hour Stay Procedure, a Multi-center Randomized Controlled Trial
Status: UNKNOWN
Conditions: Ileostomy - Stoma
Interventions: OTHER: Early discharge from hospital
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Clinical Trial to Evaluate Efficacy, Safety and Tolerance of BCD-054 and Avonex® for Treatment of Patients With Remitting-relapsing Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: BIOLOGICAL: BCD-054 180 mcg|BIOLOGICAL: Avonex®|BIOLOGICAL: BCD-054 240 mcg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 3rd-year Post-surgical Evaluation of Adjacent Segment Disc Degeneration Onset in Lumbar Spine (Spinal Fusion vs. Lumbar Arthroplasty With Disc Replacement)
Status: WITHDRAWN
Conditions: Spine Surgery
Interventions: OTHER: Consultation involving pain evaluation, questionnaires and the Lasègue Manoeuver|OTHER: Magnetic Resonance Imaging of the lumbar spine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Predicting Cell Death by Radiation Therapy in Early Stage Non-small Cell Lung Cancer: a Prospective Translational Trial
Status: TERMINATED
Conditions: Early Stage Non-small Cell Lung Cancer
Interventions: RADIATION: hypofractionated radiation therapy followed by surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Machine Learning Approach to Study the Interactions Between Environment and Intestinal Tissue Homeostasis in IBD
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 1|Ulcerative Colitis
Interventions: OTHER: Environmental factor monitoring; collection of blood, feces and urine. For UC: collection of 8 additional biopsies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Low Dose of Hydrocortisone and Fludrocortisone in Adult Cardiogenic Shock.
Status: COMPLETED
Conditions: Cardiogenic Shock
Interventions: COMBINATION_PRODUCT: Hydrocortisone + Flucortac|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Mobile Health Technology Application on Proximal Humerus Fracture Care Practice
Status: NOT_YET_RECRUITING
Conditions: Proximal Humerus Fracture|Trauma
Interventions: OTHER: Step wise post-procedure mobile health shared rehabilitation teaching video instructions modules (as per fracture type)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Prospective, Single-Arm Study to Evaluate the Efficacy and Safety of Zoladex 3.6mg Combined With CEF Chemotherapy as Neo-Adjuvant Therapy in Hormone Responsive, Premenopausal, Operable Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Zoladex
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Effect of Co-administration of Itraconazole or Diltiazem on the Single-dose of Danicamtiv in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Danicamtiv|DRUG: Itraconazole|DRUG: Diltiazem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Standard Isolation With Targeted Isolation for Preventing Nosocomial Transmission of MRSA and VRE
Status: COMPLETED
Conditions: MRSA|VRE Infection
Interventions: OTHER: Standard Contact Isolation|OTHER: Targeted Contact Isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Open-label Study to Investigate the Safety, PK, and Pharmacodynamics of GSK1120212 in Subjects With Solid Tumors or Lymphoma
Status: COMPLETED
Conditions: Solid Tumours
Interventions: DRUG: GSK1120212
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Application of Remote and Intra-Coronary Ischemic Conditioning in Acute Myocardial Infarction
Status: ACTIVE_NOT_RECRUITING
Conditions: Myocardial Infarction, Acute
Interventions: DEVICE: Remote ischemic conditioning and intracoronary ischemic conditioning|DEVICE: Patients with no remote ischemic conditioning and no intracoronary ischemic conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SELIBORDARA: Selinexor, Bortezomib and Daratumumab in Multiple Myeloma
Status: UNKNOWN
Conditions: Refractory Multiple Myeloma
Interventions: DRUG: Selinexor|DRUG: Daratumumab|DRUG: Bortezomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studying Blood Samples From Women With Breast Cancer or Ductal Carcinoma In Situ Who Are Receiving Tamoxifen
Status: COMPLETED
Conditions: Breast Cancer|Menopausal Symptoms
Interventions: DRUG: tamoxifen citrate|GENETIC: gene expression analysis|OTHER: pharmacogenomic studies|OTHER: questionnaire administration|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Programs To Support You During Chemotherapy
Status: COMPLETED
Conditions: Depression|Fatigue|Stage IIA Colorectal Cancer|Stage IIB Colorectal Cancer|Stage IIC Colorectal Cancer|Stage IIIA Colorectal Cancer|Stage IIIB Colorectal Cancer|Stage IIIC Colorectal Cancer|Stage IVA Colorectal Cancer|Stage IVB Colorectal Cancer|Pancreatic Cancer|Esophageal Cancer|Appendix Cancer|Stomach Cancer|Gallbladder Cancer|Liver Cancer|Small Intestine Cancer|Large Intestine Cancer|Anal Cancer|Biliary Tract Cancer|Gastrointestinal Stromal Cancer
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Questionnaire Administration|OTHER: Daily Survey Administration|BEHAVIORAL: Yoga Skills Training|BEHAVIORAL: Attention Control|OTHER: Actigraphy Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ADR-002K for Patients With Ischemic Cardiomyopathy Who Undergo Coronary Artery Bypass Surgery
Status: UNKNOWN
Conditions: D017202
Interventions: BIOLOGICAL: ADR-002K administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter, Randomized, Comparative and Prospective Study Evaluating the Impact on the Care Path of an Editorial Program Accompanied by Advance Directives in Psychiatry (DAP) for People Suffering From Schizophrenia, Bipolar I Disorder or Schizoaffective Disorder
Status: COMPLETED
Conditions: Schizophrenia|Bipolar I Disorder
Interventions: BEHAVIORAL: Psychiatric Advanced Directive|BEHAVIORAL: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dose-related Effects of Vitamin D3 on Immune Responses in Patients With Clinically Isolated Syndrome
Status: COMPLETED
Conditions: Clinically Isolated Syndrome|Multiple Sclerosis
Interventions: DIETARY_SUPPLEMENT: 5000IU vitamin D|DIETARY_SUPPLEMENT: 10000IU vitamin D|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Meta-analyses of the Effect of Dietary Pulses on Acute Postprandial Metabolic Control
Status: UNKNOWN
Conditions: Diabetes|Prediabetes|Dysglycemia|Overweight|Obesity|Metabolic Syndrome|Cardiovascular Disease
Interventions: OTHER: Dietary pulses
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety Study of Bipolar Versus Monopolar Transurethral Resection of Bladder Tumors
Status: COMPLETED
Conditions: Neoplasm of Lateral Wall of Urinary Bladder
Interventions: DEVICE: Bipolar transurethral resection of the urinary bladder (PlasmaKinetic, Gyrus, Fresenius)|DEVICE: Monopolar transurethral resection of the urinary bladder (Storz GmbH &Co., Erbotom, Purisole)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrical Activity of the Diaphragm During the Weaning Period
Status: COMPLETED
Conditions: Respiratory Insufficiency
Interventions: DEVICE: Neurally adjust ventilatory assist (NAVA) and a nasogastric tube to measure the electrical activity of the diaphragm (EAdi catheter)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Efficacy of Intercostal Nerve Block vs Peritract Infiltration With 0.25% Bupivacaine in PCNL
Status: UNKNOWN
Conditions: Kidney Stone
Interventions: PROCEDURE: Intercostal Nerve Block|PROCEDURE: Peritract Infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Subcutaneous Ketamine for Postoperative Pain Relief in Rwanda
Status: COMPLETED
Conditions: Post Operative Pain|Pain
Interventions: DRUG: Ketamine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Glaucoma Educators on Adherence to Prescribed Therapeutic Regimens in Glaucoma Patients
Status: COMPLETED
Conditions: Glaucoma
Interventions: BEHAVIORAL: standard of care|OTHER: education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Amyloid Prediction in Early Stage Alzheimer's Disease From Acoustic and Linguistic Patterns of Speech
Status: COMPLETED
Conditions: Alzheimer Disease|Preclinical Alzheimer's Disease|Prodromal Alzheimer's Disease|Alzheimer's Disease (Incl Subtypes)|Mild Cognitive Impairment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Safety and Efficacy of DIOR Balloon in Coronary Bifurcation Lesions
Status: UNKNOWN
Conditions: Percutaneous Coronary Intervention
Interventions: DEVICE: Paclitaxel-Eluting Coronary Balloon Dilation Catheter (DIOR)|DEVICE: Paclitaxel-Eluting Balloon (Bingo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Penile Tissue Allotransplantation for Devastating Penile and Concomitant Genital Trauma
Status: WITHDRAWN
Conditions: Urologic Injuries|Genital Diseases, Male|Amputation
Interventions: PROCEDURE: Penile Transplant|BIOLOGICAL: Monoclonal Antibody (Humanized Anti-CD52)|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Efficacy and Safety of Rozanolixizumab in Adult Patients With Generalized Myasthenia Gravis
Status: COMPLETED
Conditions: Generalized Myasthenia Gravis
Interventions: DRUG: Rozanolixizumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ASTX727, Venetoclax, and Gilteritinib for the Treatment of Newly Diagnosed, Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome|Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: DRUG: Decitabine and Cedazuridine|DRUG: Gilteritinib|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Xylitol-Containing Chewing Gum With/Without Bicarbonate Versus Paraffin Pellet on Salivary pH
Status: UNKNOWN
Conditions: Dental Caries
Interventions: OTHER: Xylitol|OTHER: xylitol with bicarbonate|OTHER: paraffin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Food Concentrates Supplementation to Alleviate Asthma in Children
Status: COMPLETED
Conditions: Asthma
Interventions: DIETARY_SUPPLEMENT: food concentrates: fruit, vegetable, fish oil and probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Bern Heart and Brain Interaction Study - Interaction Between Brain and Heart in Acute Ischemic Stroke
Status: RECRUITING
Conditions: Acute Stroke
Interventions: PROCEDURE: Short cardiovascular MRI (CMR)|PROCEDURE: Adenosine-perfusion cardiovascular MRI (CMR)|PROCEDURE: Blood draw|PROCEDURE: Urine (collection over 24h)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Percutaneous Cholangiopancreatoscopy Registry
Status: RECRUITING
Conditions: Biliary Stones|Cholangiocarcinoma, Intrahepatic|Biliary Stricture|Cholelithiasis|Choledocholithiasis
Interventions: PROCEDURE: Percutaneous cholangiopancreatoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of Morphine on Desflurane Consumption and Recovery Time
Status: COMPLETED
Conditions: Abdominal Hysterectomy (& Wertheim)
Interventions: DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study Assessing Synchronisation of Egg Sacs With Degarelix
Status: COMPLETED
Conditions: Infertility, Female
Interventions: DRUG: Degarelix mid-luteal, 2.5 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Spinal Cord Stimulation (SCS) Therapy Study
Status: WITHDRAWN
Conditions: Failed Back Surgery Syndrome|Degenerative Disk Disease|Epidural Fibrosis|Arachnoiditis|Radiculopathies
Interventions: DEVICE: Therapy Setting 1 (Medtronic)|DEVICE: Therapy Setting 2 (Medtronic)|DEVICE: Therapy Setting 3 (Medtronic)|DEVICE: Therapy Setting 4 (Medtronic)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study for Efficacy and Dose Escalation of AD313 + Atomoxetine (SEED)
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: Dosing 1: Atomoxetine|DRUG: AD313
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Upper Extremity-based Exercises and Elbow-focused Exercises in LET
Status: RECRUITING
Conditions: Lateral Epicondylitis|Elbow Tendinopathy
Interventions: BEHAVIORAL: Elbow focused rehabilitation|BEHAVIORAL: Scapular and rotator cuff muscles strengthening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Restrictive or Doppler-guided Fluid Treatment in Colorectal Surgery
Status: COMPLETED
Conditions: Fluid Overload
Interventions: DRUG: Voluven to near maximal stroke volume of the heart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Functional Outcomes From Diets in Multiple Sclerosis
Status: RECRUITING
Conditions: Relapsing Remitting Multiple Sclerosis|Secondary Progressive Multiple Sclerosis
Interventions: BEHAVIORAL: Glycemic load|BEHAVIORAL: Calorie restriction|BEHAVIORAL: Behavioral support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Exercise Intervention in Women Diagnosed With Triple-negative Breast Cancer Receiving Oncologic Treatment
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Triple Negative Breast Cancer
Interventions: OTHER: Exercise intervention - High intensity interval training on a cycle-ergometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of the Medical Device DECAP CO2 for the Treatment of Hypercapnic Respiratory Distress in Patients Under Noninvasive Ventilation
Status: UNKNOWN
Conditions: Respiratory Distress Syndrome|Hypercapnia
Interventions: DEVICE: Extracorporeal CO2 removal device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breathlessness Exertion and Morphine Sulphate
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Dyspnea
Interventions: DRUG: Placebo|DRUG: Morphine Sulfate|DRUG: Plus laxative (Docusate with senna)|DRUG: Plus placebo laxative|DEVICE: FitBit charge HR (Accelerometer)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ADDM Study - Amtrel and Co-Diovan in Type 2 Diabetes Mellitus Hypertension Patients With Microalbuminuria
Status: COMPLETED
Conditions: Hypertension|Diabetes Mellitus, Type 2|Albuminuria
Interventions: DRUG: Amlodipine+Benazepril|DRUG: Valsartan+Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of MBSR (Mindfulness-Based Stress Reduction) Program on Anxiety, Work-Related Emotional Burnout and Job Satisfaction in Midwives
Status: COMPLETED
Conditions: Midwives|Mindfulness|Anxiety|Professional Burnout|Job Satisfaction
Interventions: BEHAVIORAL: Mindfulness-based stress reduction (MBSR) program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Etonogestrel + 17β-Estradiol Vaginal Ring (MK-8342B) in the Treatment of Women With Primary Dysmenorrhea (MK-8342B-060)
Status: TERMINATED
Conditions: Dysmenorrhea
Interventions: DRUG: ENG 125 μg + E2 300 μg vaginal ring (MK-8342B)|DRUG: Placebo vaginal ring|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of AMG 510 in Combination With MVASI in Patients With Advanced, Unresectable or Metastatic KRAS G12C Mutant NSCLC With Asymptomatic Brain Metastasis
Status: WITHDRAWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: AMG 510|DRUG: MVASI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Contact Lenses and Conjunctival Staining in Normal Patients
Status: COMPLETED
Conditions: Conjunctival Staining
Interventions: DEVICE: Complete Easy Rub|DEVICE: ReNu MultiPlus|DEVICE: Clear Care|DEVICE: Contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Nomad P-KAFO Study
Status: RECRUITING
Conditions: Cerebrovascular Accident|Post-polio Syndrome|Spinal Cord Injuries|Multiple Sclerosis|Muscular Dystrophy|Paralysis
Interventions: DEVICE: Indego Nomad® Powered Knee-Ankle-Foot Orthosis (P-KAFO) (Parker Hannifin Corp., Cleveland, OH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Bioeffects of Alirocumab in Non-treatment Seeking Heavy Drinkers
Status: RECRUITING
Conditions: Alcohol Associated Liver Disease|Heavy Drinking Behavior
Interventions: DRUG: Alirocumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE