pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Augmented Hyper-CVAD in Acute Lymphoblastic Leukemia Salvage
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Cyclophosphamide (CTX)|DRUG: Vincristine|DRUG: Doxorubicin|DRUG: Decadron|DRUG: G-CSF|DRUG: Methotrexate (MTX)|DRUG: Ara-C|DRUG: Pegaspargase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient's Informational Privacy in Prehospital Emergency Care - Educational Intervention Study for the Paramedics
Status: COMPLETED
Conditions: Knowledge|Attitude of Health Personnel
Interventions: OTHER: Educational intervention - Yksityisyyttä ensihoitoon / Informational privacy for preospital emergency care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Heart Rate Variability, Physical Activity and Exhaustion in the Inpatient Treatment of Stress-Related Disorders
Status: RECRUITING
Conditions: Depression|Burnout|Stress Related Disorder
Interventions: DIAGNOSTIC_TEST: Heart rate variability, blood pressure and pulse wave velocity|DIAGNOSTIC_TEST: Assessment of cognitive function, balance, strength and cardiorespiratory fitness|BEHAVIORAL: Monitoring of physical activity and sleep|BEHAVIORAL: Monitoring of self-rated exhaustion, mood and tension
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparing the Effects of Mobilization With Movement (MWM), Self MWM, and Dynamic Stretching on Hip Internal Rotation)
Status: COMPLETED
Conditions: Hip; Anomaly
Interventions: OTHER: Hip Mobilization with Movement, Self-Mobilization with Movement, Dynamic Stretch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Filgrastim in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Bladder Cancer|Breast Cancer|Carcinoma of Unknown Primary|Esophageal Cancer|Gastric Cancer|Head and Neck Cancer|Lung Cancer|Melanoma (Skin)|Ovarian Cancer|Pancreatic Cancer|Prostate Cancer|Sarcoma
Interventions: BIOLOGICAL: filgrastim|DRUG: docetaxel|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Ambulatory and Functional Improvement by Morning Walk
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Knee|Robotics
Interventions: DEVICE: Morning walk|OTHER: no Morning walk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Possible Efficacy and Safety of Empagliflozin in Patient With Ulcerative Colitis
Status: NOT_YET_RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: Empagliflozin|DRUG: conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Brief Communal Coping Intervention for Adults With Type 1 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1
Interventions: BEHAVIORAL: Communal Coping Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AmnioExcel® Plus vs SOC in the Management of Diabetic Foot Ulcers
Status: WITHDRAWN
Conditions: Diabetic Foot Ulcer
Interventions: OTHER: AmnioExcel Plus Amniotic Membrane|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PREventing Adverse Events Post-Discharge Through Proactive Identification, Multidisciplinary Communication, and Technology
Status: COMPLETED
Conditions: Transitions of Care|General Medicine|Discharge Checklist|Adverse Event
Interventions: BEHAVIORAL: Pre-Discharge Checklist and Patient Safety Dashboard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: To Evaluate the Safety and Efficacy of Inhaled CT-P63 and CT-P66 Combination Therapy in Symptomatic Patients With COVID-19 Not Requiring Supplemental Oxygen
Status: WITHDRAWN
Conditions: COVID-19
Interventions: BIOLOGICAL: CT-P63 and CT-P66 / Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Vertebral Body Tethering on Lumbar Paraspinal Muscle Cross-Section Area in Adolescent Idiopathic Scoliosis
Status: UNKNOWN
Conditions: Idiopathic Scoliosis
Interventions: DIAGNOSTIC_TEST: Lumbar Spine Magnetic Resonance|DIAGNOSTIC_TEST: Isokinetic trunk flexion-extension trunk muscle strength and endurance test|DIAGNOSTIC_TEST: Lomber Region Range of motion assessment|DIAGNOSTIC_TEST: Radiograph|BEHAVIORAL: SRS 22
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Development of Autistic Children Based on Mothers´Response in Autism Behavior Checklist
Status: COMPLETED
Conditions: Autism|Asperger Syndrome
Interventions: OTHER: Speech Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Testing the Use of a Perivascular Sirolimus Formulation (Sirogen) in ESRD Patients Undergoing AV Fistula Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Complication of Renal Dialysis|End Stage Renal Disease|End Stage Kidney Disease|ESRD|Chronic Kidney Failure|Complication of Hemodialysis|Vascular Access Complication|Arteriovenous Fistula
Interventions: DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Epigenetic and Microbiota Modifications
Status: COMPLETED
Conditions: Diabetes type2|Obesity
Interventions: DIETARY_SUPPLEMENT: Lactobacillus fermentum D3|BIOLOGICAL: Fecal microbiota transplant (FMT)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Clinical and Radiographic Findings in Patients Treated Surgically for Biceps Long Head Injury
Status: NOT_YET_RECRUITING
Conditions: Bicep Tendon Rupture
Interventions: DIAGNOSTIC_TEST: radiographic control
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Real-world Experience of Catheter Ablation Using Novel Ablation Technologies for the Treatment of Atrial Fibrillation
Status: NOT_YET_RECRUITING
Conditions: Paroxysmal Atrial Fibrillation|Persistent Atrial Fibrillation
Interventions: DEVICE: Catheter ablation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety and Tolerability of YM150 in Healthy Caucasian and Japanese Male and Female Subjects, and to Assess the Effect That Gender May Have on Its Actions in the Body
Status: COMPLETED
Conditions: Pharmacokinetics|Pharmacodynamics|Healthy Subjects|Caucasian|Japanese
Interventions: DRUG: YM150|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Unilateral Versus Bilateral Neuromodulation Tests in the Treatment of Refractory Idiopathic Overactive Bladder
Status: COMPLETED
Conditions: Urinary Bladder, Overactive
Interventions: PROCEDURE: Unilateral electrode placement and testing|PROCEDURE: Bilateral electrode placement and testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of SBT6050 Alone and in Combination With PD-1 Inhibitors in Subjects With Advanced HER2 Expressing Solid Tumors
Status: UNKNOWN
Conditions: HER2 Positive Solid Tumors
Interventions: DRUG: SBT6050|DRUG: pembrolizumab|DRUG: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Chronic Lymphocytic Leukemia in Patients Previously Exposed to Rituximab
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Ofatumumab|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Joint Line Reconstruction in Navigated Total Knee Arthroplasty Revision
Status: UNKNOWN
Conditions: Revision Total Knee Arthroplasty Because of|Loosening|Instability|Impingement|or Other Reasons Accepted as Indications for TKA Exchange.|The Focus is to Determine the Precision of Joint Line Restoration in Navigated vs. Conventional Revision Total Knee Arthroplasty
Interventions: DEVICE: navigated revision knee arthroplasty|DEVICE: conventional revision knee arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Monıtorıng Glucocortıcoıd Treatment In Patıents Followed In Rheumatology Clınıc
Status: UNKNOWN
Conditions: Glucocorticoids Toxicity|Rheumatoid Arthritis|Vasculitis|Systemic Lupus Erythematosus
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nasal Versus Buccal Oxygen Administration for Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration
Status: COMPLETED
Conditions: Lung Diseases
Interventions: OTHER: nasal oxygen|OTHER: buccal oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A First Time in Human Study in Healthy Volunteers to Investigate a New Medicine to Treat Malaria
Status: TERMINATED
Conditions: Malaria
Interventions: DRUG: GSK932121; Rosiglitazone; Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Repair of Orthodontically-induced Tooth Root Resorption by Ultrasound
Status: UNKNOWN
Conditions: Root Resorption
Interventions: PROCEDURE: Repairing Induced tooth root resorption by ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of MG in the Patients With Alcoholic Fatty Liver Disease and Alcoholic Hepatitis
Status: COMPLETED
Conditions: Alcoholic Fatty Liver Disease|Alcoholic Hepatitis
Interventions: DRUG: Placebo /bid P.O|DRUG: MG-1|DRUG: MG-2 : MG1000mg, Placebo /bid P.O|DRUG: metadoxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Lower Limb Kinetic Chain Exercise in Shoulder Impingement
Status: RECRUITING
Conditions: Shoulder Impingement Syndrome
Interventions: OTHER: exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Allovectin-7® for Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma|Metastatic Melanoma|Malignant Melanoma|Skin Cancer
Interventions: GENETIC: Allovectin-7®
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PREMIUM Migraine Trial
Status: COMPLETED
Conditions: Migraine Headaches|Patent Foramen Ovale
Interventions: OTHER: Sham Procedure|DEVICE: AMPLATZER PFO Occluder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Efficacy of Ultrasound Guided Bilateral Erector Spinae Plane Block in Pediatric.
Status: COMPLETED
Conditions: Anesthesia, Local|Analgesia
Interventions: PROCEDURE: bilateral erector spinae block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lornoxicam With Low Dose Ketamine Versus Pethidine to Control Pain of Acute Renal Colic
Status: COMPLETED
Conditions: Renal Colic
Interventions: DRUG: Lornoxicam and mepridine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of RP-6306 Alone or in Combination With RP-3500 or Debio 0123 in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: RP-6306|DRUG: RP-3500|DRUG: Debio0123
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ocrelizumab in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment (DMT)
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Ocrelizumab|DRUG: Ocrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: rTMS for Suicidality in Opioid Use Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder|Opioid-use Disorder
Interventions: DEVICE: Active TBS|DEVICE: Sham TBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PUL vs TURP in BPH Patients With Urinary Retention
Status: RECRUITING
Conditions: BPH With Urinary Obstruction
Interventions: DEVICE: Prostatic Urethral Lift|PROCEDURE: TURP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Use of DryNites Absorbent Pants on the Rate of Spontaneous Resolution of Paediatric Nocturnal Enuresis (NE)
Status: UNKNOWN
Conditions: Nocturnal Enuresis
Interventions: DEVICE: DryNites Pyjama Pants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET)
Status: COMPLETED
Conditions: High Risk Polycythemia Vera|High Risk Essential Thrombocythemia
Interventions: DRUG: PEGASYS|DRUG: Hydroxyurea|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Study to Evaluate the Safety and Efficacy of Paltusotine for the Treatment of Acromegaly (ACROBAT Edge)
Status: COMPLETED
Conditions: Acromegaly
Interventions: DRUG: Paltusotine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Infiltration With Resin in Treatment of MIH Incisors in Children Showing Opacities
Status: ACTIVE_NOT_RECRUITING
Conditions: Children, Adult|Molar Incisor Hypomineralization|Dental Diseases|Opacity|Anterior Teeth
Interventions: PROCEDURE: white defects|PROCEDURE: yellow defects|PROCEDURE: brown defects
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment for Nonspecific Low Back Pain in Primary Care: a Trial on Different Health Education Booklets
Status: COMPLETED
Conditions: Low Back Pain
Interventions: BEHAVIORAL: The Back Book|BEHAVIORAL: The Back Guide|BEHAVIORAL: General health book
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Multiparametric MR-Guided High Dose Adaptive Radiotherapy With Concurrent Temozolomide in Patients With Newly Diagnosed Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma
Interventions: RADIATION: Dose-Intensified Radiotherapy|DRUG: Temozolomide|DRUG: Adjuvant temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SKin and Soft Tissue Necrotizing INfections in the Intensive Care Unit: a Prospective Multi-national Cohort Study
Status: UNKNOWN
Conditions: Necrotizing Fasciitis|Fournier Gangrene|Necrotizing Soft Tissue Infection
Interventions: OTHER: non interventional
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pancreaticogastrostomy Versus Pancreaticojejunostomy in Reconstruction After Cephalic Duodenopancreatectomy
Status: UNKNOWN
Conditions: Pancreatic Cancer|Pancreatic Anastomotic Leak
Interventions: PROCEDURE: Pancreatico gastro anastomosis|PROCEDURE: Pancreaticojejuno anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Myofascial Release Technique and Instrument Assisted Soft Tissue Mobilization in Lumbar Region
Status: COMPLETED
Conditions: Trigger Point Pain, Myofascial
Interventions: OTHER: Myofascial Release Technique|OTHER: Instrument Assisted Soft tissue Mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effectiveness of Strengthening the Growth Monitoring and Promotional Activities in Rural Bangladesh
Status: UNKNOWN
Conditions: Nutritional Status
Interventions: OTHER: NGO supported GMP program|OTHER: Non-supported GMP program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase II Comparator Study of Substitution of Tenofovir or Abacavir Receiving Thymidine Analogue as Part of HAART.
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: tenofovir disoproxil fumarate|DRUG: Abacavir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Belantamab Mafodotin in Newly Diagnosed Transplant Eligible Multiple Myeloma Patients
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Belantamab mafodotin|DRUG: Bortezomib|DRUG: Lenalidomide|DRUG: Dexamethasone|PROCEDURE: Autologous stem cell transplant (ASCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clindamycin 300 mg Capsules in Healthy Subjects Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Clindamycin 300 mg capsule|DRUG: Cleocin HCl 300 mg capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Liraglutide Versus Sulphonylurea Both in Combination With Metformin During Ramadan in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: metformin|DRUG: sulphonylurea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Intra-articular Multiple Doses of Icatibant in Patients With Painful Knee Osteoarthritis
Status: COMPLETED
Conditions: Joint Disease
Interventions: DRUG: HOE140 Icatibant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Routine Physical Therapy With Intensive Bimanual Training in Cerebral Palsy Children
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: home based intensive bimanual training|OTHER: Routine Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Biomarkers of Periodontitis and Type 2 Diabetes Mellitus in Males and Females 30 - 70 Years of Age
Status: NOT_YET_RECRUITING
Conditions: Periodontal Disease
Interventions: PROCEDURE: Investigational Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial of Ultrasound Combined With Computed Tomography Guided Lumbar Sympathetic Ganglion Block
Status: UNKNOWN
Conditions: Pain, Chronic|Sympathetic Disorder|Ultrasound Therapy
Interventions: DEVICE: ultrasound and CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Comparing the Safety and Efficacy of Two Dosing Regimens of TP-03 for the Treatment of MGD
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction|Blepharitis|Demodex Infestation
Interventions: DRUG: TP-03|DRUG: TP-03 Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Study of the Safety and Efficacy of Anti-CD7 Allogeneic CAR-T Cells (WU-CART-007) in Patients With Relapsed or Refractory T-ALL/LBL
Status: COMPLETED
Conditions: T-cell Acute Lymphoblastic Leukemia|Lymphoblastic Lymphoma
Interventions: BIOLOGICAL: WU-CART-007
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Hemodynamics Comparison After High Spinal Block With or Without Intrathecal Morphine.
Status: UNKNOWN
Conditions: Vasoplegia
Interventions: DRUG: Bupivacaine|DRUG: Bupivacaine + Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Mesothelioma Avastin Plus Pemetrexed-cisplatin Study
Status: COMPLETED
Conditions: Mesothelioma
Interventions: DRUG: Standard Chemotherapy (Pemetrexed and Cisplatin)|DRUG: Standard Chemotherapy (Pemetrexed and Cisplatin) + Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nirogacestat in Ovarian Granulosa Cell Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Granulosa-Stromal Tumor|Ovarian Granulosa Cell Tumor|Ovarian Cancer
Interventions: DRUG: Nirogacestat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy and Safety of PLN-74809 in Patients With Idiopathic Pulmonary Fibrosis
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: PLN-74809|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Samples Procurement for Colorectal Cancer, Gastric Cancer, and Non-malignant Disease
Status: RECRUITING
Conditions: Colorectal Cancer|Gastric Cancer|Inflammatory Bowel Diseases|Gastric Ulcer|Hemorrhoids|Hernia
Interventions: OTHER: No intervention will be given to patients.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: "VARIABLE-PSV" Study
Status: COMPLETED
Conditions: Acute Respiratory Failure|Critical Illness|Ventilation Weaning
Interventions: OTHER: VARIABLE-PSV ventilatory mode|OTHER: STANDARD-PSV ventilatory mode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Two Formulations of Biphasic Insulin Aspart 70 in Healthy Subjects
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: biphasic insulin aspart 70
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Coenzyme Q10 in Relieving Treatment-Related Fatigue in Women With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Fatigue
Interventions: DIETARY_SUPPLEMENT: CoQ10 & Vitamin E|DIETARY_SUPPLEMENT: Placebo & Vitamin E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cognitive Behavioural Therapy for Insomnia in Chronic Spinal Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain|Chronic Neck Pain|Insomnia Chronic
Interventions: BEHAVIORAL: MNA plus CBT-I|BEHAVIORAL: MNA alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Bifocals in Children With Down Syndrome
Status: COMPLETED
Conditions: Visual Acuity at Near|Accuracy of Accommodation|Prevention of Strabismus|Task Readiness
Interventions: DEVICE: bifocals|DEVICE: single vision glasses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of GNC-038 Injection in Patients With Relapsed or Refractory NK/ T-cell Lymphoma, AITL, and Other NHL
Status: RECRUITING
Conditions: NK/T Cell Lymphoma|Vascular Immunomother T Cell Lymphoma|Non-Hodgkin Lymphoma
Interventions: DRUG: GNC-038
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ABRA Abdominal Closure System in Open Abdomen Management
Status: COMPLETED
Conditions: Open Abdomen
Interventions: DEVICE: ABRA Abdominal Closure System|DEVICE: V.A.C. Therapy|DEVICE: KCI ABThera
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Botulinum Neurotoxin Serotype E (EB-001) in Reducing Musculoskeletal Pain in Abdominoplasty
Status: TERMINATED
Conditions: Abdominoplasty
Interventions: BIOLOGICAL: Botulinum Neurotoxin Serotype E|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Concomitant Cryomaze Procedure Using Nitreous Oxide Cryoprobe: Comparison With Argon Based Cryoprobe
Status: COMPLETED
Conditions: Atrial Fibrillation|Valve
Interventions: DEVICE: Cryomaze procedure using Nitrous oxide|DEVICE: Cryomaze procedure using Argon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide Safety/Efficacy in Myelodysplastic Syndromes (MDS) Associated With a Deletion (Del)(5q) Cytogenetic Abnormality
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Mineral Trioxide Aggregate (MTA) and 20% Formocresol (FC) in Pulpotomized Human Primary Molars
Status: UNKNOWN
Conditions: Dental Caries|Pulpitis
Interventions: DRUG: Gray Mineral Trioxide Aggregate (GMTA)|DRUG: Diluted (20%) Formocresol (DFC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Rigid Versus Semirigid Thoracoscopy in the Evaluation of Exudative Pleural Effusions
Status: COMPLETED
Conditions: Pleurisy With Effusion
Interventions: DEVICE: Rigid thoracoscope (Richard Wolf GmbH, Knittlingen, Germany)|DEVICE: Semirigid thoracoscope (model LTF-160Y1, Olympus, Japan)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Epinephrine in the Pediatric Intensive Care Unit: A Dose-Effect Trial
Status: ENROLLING_BY_INVITATION
Conditions: Hypotension
Interventions: DRUG: Epinephrine 0.5 mcg/kg|DRUG: Epinephrine 1 mcg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Imlunestrant (LY3484356) in Female Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Imlunestrant|DRUG: Repaglinide|DRUG: Omeprazole|DRUG: Dextromethorphan|DRUG: Quinidine|DRUG: Rosuvastatin|DRUG: Digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Quality of Life Intervention (Y-AMBIENT) for Young African American With Stage I-III Breast Cancer
Status: RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8
Interventions: OTHER: Best Practice|OTHER: Educational Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Azithromycin 600 Mg Tablets, Fasting
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Azithromycin 600 mg Tablet|DRUG: Zithromax® 600 mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The MILE Study: A Motivational, Individual and Locally Anchored Exercise Intervention in 30-49 Year Olds.
Status: UNKNOWN
Conditions: Physical Activity
Interventions: BEHAVIORAL: physical activity|OTHER: Motivational interview|OTHER: Virtual arena
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: BOTOX® Efficacy and Safety in the Treatment of Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: BIOLOGICAL: onabotulinumtoxinA|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Elaboration of Patient-friendly Treatment Strategy With Capsaicin Nasal Spray in Patients With Idiopathic Rhinitis
Status: COMPLETED
Conditions: Non-allergic Rhinitis
Interventions: DRUG: Capsaicin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of IONM on Efficacy and Safety Using Sugammadex in Thyroid Surgery
Status: UNKNOWN
Conditions: Vocal Cord Paralysis|Recurrent Laryngeal Nerve
Interventions: DRUG: Group B. Sugammadex sodium-IONM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Yield of Diagnostic Tests and Effects of Crofelemer for Chronic Idiopathic Diarrhea In Non-HIV Patients
Status: RECRUITING
Conditions: Chronic Diarrhea of Unknown Origin
Interventions: DRUG: Crofelemer|DIAGNOSTIC_TEST: Diagnostic tests for cause of chronic diarrhea
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of a FAAH-Inhibitor to Treat Cannabis Withdrawal
Status: COMPLETED
Conditions: Cannabis Dependence
Interventions: DRUG: PF-04457845|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NasoNeb Delivery of an Intranasal Steroid
Status: COMPLETED
Conditions: Perennial Allergic Rhinitis
Interventions: DRUG: Budesonide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Closed-Loop Oxygen to Verify That Healthcare Workers Interventions Decrease During SARS-CoV-2 Pneumonia (COVID-19)
Status: UNKNOWN
Conditions: Coronavirus|Pneumonia|Oxygen Toxicity
Interventions: OTHER: Standard administration of oxygen flow|DEVICE: Automated oxygen administration - FreeO2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Angle of the Metacarpophalangeal Joint of the Thumb During Maximal Pinch Strength
Status: COMPLETED
Conditions: Post-traumatic; Arthrosis|Osteoarthritis Thumb
Interventions: OTHER: measurement of range of motion and strength
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of LiveSpo X-secret in Supporting Treatment of Sexually Transmitted Diseases
Status: COMPLETED
Conditions: Sexually Transmitted Diseases
Interventions: COMBINATION_PRODUCT: LiveSpo X-secret|DRUG: 0.9% NaCl physiological saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Exercise Training and Ketone Ester on Muscle Strength and Cardiovascular Response in Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DIETARY_SUPPLEMENT: Ketone Ester Beverage|DIETARY_SUPPLEMENT: Electrolyte Beverage|BEHAVIORAL: Cycling Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Self-acupressure for Cancer-related Symptom Cluster of Insomnia, Depression, and Anxiety: a Feasibility Study
Status: UNKNOWN
Conditions: Insomnia|Anxiety|Depression
Interventions: OTHER: Self-acupressure|OTHER: Sham Self-acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of P3914 to Evaluate the Safety, Tolerability, Food Effect & Pharmacokinetics in Healthy Male Subjects and Efficacy & Safety of P3914 in Patients With Acute Dental Pain
Status: TERMINATED
Conditions: Acute Dental Pain
Interventions: DRUG: P3914|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of STAHIST in Seasonal Allergic Rhinitis Patients
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal
Interventions: DRUG: STAHIST NDC #58407-536-01
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of CBT-004 in Patients With Vascularized Pinguecula
Status: RECRUITING
Conditions: Pinguecula
Interventions: DRUG: CBT-004
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Methylphenidate for the Treatment of PTSD With Associated Neurocognitive Complaints
Status: RECRUITING
Conditions: Posttraumatic Stress Disorder (PTSD)
Interventions: DRUG: Methylphenidate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Insulin Efsitora Alfa (LY3209590) as a Weekly Basal Insulin Compared to Insulin Glargine in Adult Participants With Type 2 Diabetes on Multiple Daily Injections
Status: COMPLETED
Conditions: Type 2 Diabetes|Type 2 Diabetes Treated With Insulin
Interventions: DRUG: Insulin Efsitora Alfa|DRUG: Insulin Lispro (U100)|DRUG: Insulin Glargine (U100)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial on Effectiveness Combined Probiotics in Atopic Dermatitis in Children
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Probiatop|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: LOng COvid COmorbidities: Andrological, Reproductive, Sexual Dysfunctions in Patients Recovered From COVID-19
Status: RECRUITING
Conditions: Long Covid-19
Interventions: DIAGNOSTIC_TEST: Assessment of andrological profile of LO-COCO-ANDRO male patients|DIAGNOSTIC_TEST: Assessment of reproductive function of LO-COCO-ANDRO male patients|DIAGNOSTIC_TEST: Assessment of sexual function of LO-COCO-ANDRO male patients|DIAGNOSTIC_TEST: Assessment of olfactory function of LO-COCO-ANDRO male and female patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adjuvant Systemic Treatment for (ER)-Positive HER2-negative Breast Carcinoma in Women Over 70 According to Genomic Grade (GG): Chemotherapy + Endocrine Treatment Versus Endocrine Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: HORMONOTHERAPY|DRUG: CHEMOTHERAPY then HORMONOTHERAPY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polysomnographic Findings in Nasal Polyposis
Status: RECRUITING
Conditions: Chronic Rhinosinusitis With Nasal Polyps|Obstructive Sleep Apnea
Interventions: PROCEDURE: Endoscopic sinus surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Continuous Versus Intermittent Enteral Feeding in Critically Ill Patients
Status: UNKNOWN
Conditions: Nutrition Disorders
Interventions: OTHER: Continuous enteral feeding via infusion pump|OTHER: Intermittent enteral feeding via gravity-based infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treating Clozapine-induced Sinustachycardia With Bisoprolol
Status: COMPLETED
Conditions: Clozapine-induced Sinustachycardia
Interventions: DRUG: Bisoprolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anetumab Ravtansine and Atezolizumab in Treating Participants With Advanced Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Mesothelin Positive|Stage III Non-Small Cell Lung Cancer AJCC v7|Stage IIIA Non-Small Cell Lung Cancer AJCC v7|Stage IIIB Non-Small Cell Lung Cancer AJCC v7|Stage IV Non-Small Cell Lung Cancer AJCC v7
Interventions: BIOLOGICAL: Anetumab Ravtansine|BIOLOGICAL: Atezolizumab|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of CPAP on Cognitive Function, Neurocognitive Architecture and Function in Patients With OSA: The SMOSAT Trial
Status: COMPLETED
Conditions: Apnea, Sleep
Interventions: DEVICE: CPAP|DIETARY_SUPPLEMENT: BSC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Bictegravir/Lenacapavir in Children and Adolescents With HIV-1
Status: NOT_YET_RECRUITING
Conditions: HIV-1-infection
Interventions: DRUG: Lenacapavir|DRUG: BIC/LEN FDC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Dalotuzumab (MK-0646) in Adults With Solid Tumors (MK-0646-009)
Status: COMPLETED
Conditions: Neoplasm
Interventions: BIOLOGICAL: Dalotuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Respiration and Applied Tension Strategies to Reduce Vasovagal Reactions to Blood Donation
Status: UNKNOWN
Conditions: Syncope, Vasovagal
Interventions: BEHAVIORAL: Applied Tension|BEHAVIORAL: Respiration Control|BEHAVIORAL: Applied Tension/Respiration Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Referral of Callers to Retrieve Drone-delivered AEDs in Out-of-hospital Cardiac Arrest
Status: COMPLETED
Conditions: Out-Of-Hospital Cardiac Arrest
Interventions: DEVICE: Automated flying Drone carrying an Automated external defibrillator (AED)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Enteric-coated Mycophenolate Sodium (EC-MPS) (Myfortic) in The Treatment of Relapse or Resistant Proliferative Lupus Nephritis
Status: TERMINATED
Conditions: Lupus Nephritis
Interventions: DRUG: mycophenolate sodium|DRUG: cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SBRT Combined With Nimotuzumab and Mono-chemotherapy in Locally Advanced Pancreatic Cancer
Status: NOT_YET_RECRUITING
Conditions: Advanced Pancreatic Cancer
Interventions: RADIATION: Stereotactic body radiation|DRUG: Nimotuzumab|DRUG: mono-chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenomics IND EXEMPT SNP Clinical Study - Alectinib and Single Nucleotide Polymorphisms
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Alectinib - Usual|DRUG: Alectinib - Study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Pan-TB Regimen Targeting Host and Microbe
Status: RECRUITING
Conditions: Tuberculosis
Interventions: DRUG: Sutezolid|DRUG: N-acetyl cysteine|DRUG: Pretomanid|DRUG: Bedaquiline|COMBINATION_PRODUCT: Rifafour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Frequency of Fibromyalgia in Behcet Disease
Status: COMPLETED
Conditions: Fibromyalgia|Behcet Syndrome
Interventions: DIAGNOSTIC_TEST: group 1:Patients diagnosed with Behcet disease|DIAGNOSTIC_TEST: group 2: Patient diagnosed with fibromyalgia without Behcet disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Emovi 3D Knee Assessment Device Intervention for Operational Readiness
Status: NOT_YET_RECRUITING
Conditions: Patellofemoral Pain|Patellofemoral Pain Syndrome
Interventions: DEVICE: Emovi Knee Kinesiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Reduced GCSF Dosing in Patients With a Low to Moderate Risk of Febrile Neutropenia
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: GCSF administration on days 8 and 12 after chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Longitudinal Study of Ultra-rare Inherited Metabolic and Degenerative Neurological Diseases.
Status: UNKNOWN
Conditions: Inherited Disease|Rare Diseases|Metabolic Disease|Undiagnosed Disease|Neurologic Disorder|Neuro-Degenerative Disease
Interventions: OTHER: collection of data
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose-finding Study of Selective Serotonin Reuptake Inhibitors to Enhance Neuroplasticity
Status: WITHDRAWN
Conditions: Stroke, Ischemic
Interventions: DRUG: Administration of SSRI escitalopram|BEHAVIORAL: Paired Associative stimulation|DRUG: Administration of Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D for Enhancing the Immune System in Cystic Fibrosis (DISC Study)
Status: COMPLETED
Conditions: Cystic Fibrosis|Respiratory Tract Infections
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vertebral Body Tethering Treatment for Idiopathic Scoliosis
Status: TERMINATED
Conditions: Scoliosis|Spinal Curvatures|Spinal Diseases|Bone Diseases|Musculoskeletal Disease|Adolescent Idiopathic Scoliosis|Juvenile; Scoliosis
Interventions: DEVICE: Anterior Vertebral Body Tethering
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY