pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Remote Ischemic Preconditioning in Elective Percutaneous Interventions
Status: COMPLETED
Conditions: Myocardial Ischemia|Ischemic Reperfusion Injury
Interventions: OTHER: remote ischemic preconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of the pdSTIM™ System (Phrenic Nerve to Diaphragm STIMulation) in Failure to Wean Mechanically Ventilated Patients
Status: RECRUITING
Conditions: Ventilator Induced Diaphragm Dysfunction
Interventions: DEVICE: pdSTIM System Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression
Status: RECRUITING
Conditions: High Grade Glioma|Glioblastoma
Interventions: PROCEDURE: Standard Surgical Treatment|PROCEDURE: Intraoperative Electrocorticography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Transcranial Direct Current Stimulation and Speech Language Therapy to Improve Language Functioning in Arabic Speakers With Aphasia Post-Stroke
Status: UNKNOWN
Conditions: Aphasia
Interventions: DEVICE: Transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mass Balance Study to Investigate the Absorption, Metabolism and Excretion of [14C]-EYP001a After a Single Oral Dose
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: [14C]-EYP001a
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PureWick™ France and U.S. At-Home Pilot Study
Status: ENROLLING_BY_INVITATION
Conditions: Nocturnal Enuresis
Interventions: DEVICE: PureWick™ System|DEVICE: Hollister® Female Urinary Pouch External Collection Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed vs Pemetrexed Plus Cisplatin in EGFR-mutant NSCLC Patients After First Line EGFR-TKIs Failure
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Pemetrexed|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Humacyte Human Acellular Vessel (HAV) in Patients With Vascular Trauma
Status: ACTIVE_NOT_RECRUITING
Conditions: Trauma|Vascular System Injury
Interventions: BIOLOGICAL: Human Acellular Vessel (HAV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia
Status: COMPLETED
Conditions: Apoptotic Signal Pathways in Endometrial Hyperplasia
Interventions: DRUG: 17β estradiol hemihydrate|DRUG: Metformin|DRUG: medroxyprogesterone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nimotuzumab in Combination With Chemoradiation in Patients With Locally Advanced Rectal Cancer
Status: UNKNOWN
Conditions: Locally Advanced Rectal Cancer
Interventions: RADIATION: Preoperative irradiation|DRUG: Nimotuzumab|DRUG: Oxaliplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0312, Gemcitabine and Capecitabine in Treating Patients With Advanced Renal Cell (Kidney) Cancer
Status: COMPLETED
Conditions: Kidney Cancer
Interventions: DRUG: capecitabine|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Equivalence of Generic Clozapine to Orally Dissolving Clozapine in Schizophrenia or Schizoaffective Disorder
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Fazaclo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Obstructive Sleep Apnea Syndrome on Insulin Sensitivity and Cardiovascular Risk in PCOS Adolescents
Status: COMPLETED
Conditions: Obstructive Sleep Apnea Syndrome|Polycystic Ovary Syndrome|Sleep Apnea
Interventions: DEVICE: Nasal Continuous positive airway pressure (CPAP)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phamacological Reversal of Airway Instability During Sedation
Status: COMPLETED
Conditions: Upper Airway Obstruction
Interventions: DRUG: Physostigmine|DRUG: Oxygen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Breaking Bad News - Optimizing Stress Response and Communication Performance in Medical Students
Status: COMPLETED
Conditions: Stress Reaction
Interventions: BEHAVIORAL: Stress arousal reappraisal|BEHAVIORAL: Worked examples
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: BIOhabitats: Biological Validation of Vascular Habitats Within Astrocytoma Grade 4 at Molecular, Cellular, and Histopathological Levels
Status: UNKNOWN
Conditions: Astrocytoma, Grade IV|Glioblastoma|Glioblastoma Multiforme|Glioblastoma, IDH-wildtype|Glioblastoma, IDH-mutant|Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype|Glioblastoma IDH (Isocitrate Dehydrogenase) Mutant|High Grade Glioma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Fish Oil and Red Wine on Oxidative Stress Biomarkers
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DRUG: Fish Oil|DIETARY_SUPPLEMENT: Safflower Oil|DIETARY_SUPPLEMENT: Ethanol|DIETARY_SUPPLEMENT: Omega-3 polyunsaturated fatty acids|DIETARY_SUPPLEMENT: Omega-6 polyunsaturated fatty acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of PA-824 and of PA-824 Plus Moxifloxacin on the QTc Interval in Healthy Volunteers
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: Moxifloxacin|DRUG: PA-824|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Malnutrition in Children With Sickle Cell Disease
Status: NOT_YET_RECRUITING
Conditions: Sickle Cell Disease|Malnutrition
Interventions: BEHAVIORAL: Maternal Nutrition Education|BEHAVIORAL: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 1 Study of MDV3100 in Patients With Castration-Resistant (Hormone-Refractory) Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer|Hormone Refractory Prostate Cancer
Interventions: DRUG: MDV3100
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gengraf Conversion Study in Stable Renal Allograft Transplant Recipients
Status: COMPLETED
Conditions: End Stage Renal Failure
Interventions: DRUG: Neoral|DRUG: Gengraf® capsule containing 25mg or 100mg cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Glucosamine and Chondroitin Supplementation in Women With Knee Osteoarthritis Participating in an Exercise and Weight Loss Program
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Diet|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Size 1 I-gel and ProSeal Laryngeal Mask
Status: COMPLETED
Conditions: Laryngeal Masks
Interventions: DEVICE: I-gel|DEVICE: ProSeal Laryngeal mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Evaluate the Efficacy and Safety of TF0023 in Treatments for COVID-19 in Hospitalized Adults
Status: TERMINATED
Conditions: COVID-19 Pneumonia
Interventions: DRUG: TF0023
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coronary Microvascular Dysfunction Assessments in Myocardial Infarction With Non-Obstructive Coronary Arteries
Status: RECRUITING
Conditions: Myocardial Infarction|Coronary Microvascular Dysfunction|Vasospasm, Coronary
Interventions: DIAGNOSTIC_TEST: Intravascular imaging (OCT), Invasive physiologic assessment (FFR, CFR, IMR), or Non-invasive physiologic assessment (N-13 ammonia PET)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate Addition of Peginterferon Alfa-2a to Chronic Hepatitis B (CHB) Patients Treated With NAs
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: Peginterferon alfa-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMAAGEN: Impact of Abiraterone Acetate in Prostate-Specific Antigen
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer|Prostatic Neoplasm
Interventions: DRUG: abiraterone acetate in combination with prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Asacol Absorption, Metabolism and Excretion in Children and Adolescents With Ulcerative Colitis.
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: DRUG: mesalamine|DRUG: mesalamine|DRUG: mesalamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Pharmacokinetics, Pharmacodynamics, Safety, Tolerability, and Immunogenicity Study of SB16 in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Denosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Training in Ataxia - Individuals With Degenerative Cerebellar Diseases
Status: ACTIVE_NOT_RECRUITING
Conditions: Cerebellar Ataxia
Interventions: BEHAVIORAL: Aerobic Training|BEHAVIORAL: Balance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enamel Damages Following De-bracketing From Infiltrated Surfaces
Status: COMPLETED
Conditions: Dental White Spots
Interventions: PROCEDURE: Resin infiltration|PROCEDURE: Bonding and debonding of brackets.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Testing Promising Behavioral Economic Interventions to Promote Enrollment Diversity in Cardiovascular Cohort Studies
Status: RECRUITING
Conditions: Cardiovascular Diseases
Interventions: BEHAVIORAL: Method of Contact|BEHAVIORAL: Source of Contact|BEHAVIORAL: Framing Method (Appeal to Altruism)|BEHAVIORAL: Framing Method (Social Proof or Perceived Scarcity)|BEHAVIORAL: Framing Method (Opt-Out)|BEHAVIORAL: Incentive Structure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Promotora-Led Intervention for Metabolic and Mental Health
Status: COMPLETED
Conditions: PreDiabetes|Obesity|Metabolic Disease|Body Weight Changes|Diabetes Mellitus
Interventions: BEHAVIORAL: Promotora-led Intervention (PLI)|BEHAVIORAL: Usual care (UC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Optic Nerve Sheath Diameters in Idiopathic Intracranial Hypertension Patients
Status: COMPLETED
Conditions: Pseudotumor Cerebri
Interventions: PROCEDURE: Optic ultrasonography|PROCEDURE: Lumbar puncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Validation Study on RENEW's Aingeal at KK Women's and Children's Hospital
Status: ACTIVE_NOT_RECRUITING
Conditions: Vital Sign|Heart Rate|Respiratory Rate
Interventions: DEVICE: Vital sign monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vitamins C and Vitamin E and Cardiovascular Risk
Status: COMPLETED
Conditions: Diabetes
Interventions: DIETARY_SUPPLEMENT: Study Arm A|DIETARY_SUPPLEMENT: Study Arm B|DIETARY_SUPPLEMENT: Study Arm C|DIETARY_SUPPLEMENT: Study Arm D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Prospective Study of Medical Therapy Against Cryoballoon Ablation in Symptomatic Recent Onset Persistent AF
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: single ablation (CryoBalloonAblation (CBA)|DRUG: sequential drug adjustment (propafenone, sotalol or flecainide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GRACE-trial: a Randomized Active-controlled Trial for vulvovaGinal atRophy in breAst Cancer Patients on Endocrine Therapy.
Status: RECRUITING
Conditions: Vulvovaginal Atrophy|Breast Cancer
Interventions: DRUG: Estrogen|DRUG: dehydroepiandrosterone|DRUG: Estrogen + probiotics|DRUG: Moisturizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: To Compare the Gastrointestinal Safety of a 14-Day Oral Dosing Regimen of ATB-346 to Sodium Naproxen in Healthy Subjects
Status: COMPLETED
Conditions: Gastric Ulcer
Interventions: DRUG: ATB-346 OR Placebo|DRUG: Naproxen sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy and Safety of Different Doses of SY-009 in Patients With Type 2 Diabetes Mellitus
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: SY-009 capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Controlling Antimicrobial Use Through Reducing Unnecessary Treatment of Catheter Associated Urinary Tract Infections
Status: UNKNOWN
Conditions: Catheter-Related Infections
Interventions: OTHER: Short-course Antibiotics|DEVICE: Catheter Change
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Study to Evaluate Efficacy and Long Term Safety of LUM001 (Maralixibat) in the Treatment of Cholestatic Liver Disease in Patients With Progressive Familial Intrahepatic Cholestasis
Status: COMPLETED
Conditions: Progressive Familial Intrahepatic Cholestasis (PFIC)
Interventions: DRUG: LUM001 (Maralixibat)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aromatherapy in Management of Postoperative Nausea in Post-Bariatric Surgery Patients
Status: COMPLETED
Conditions: Bariatric Surgery Candidate|Nausea, Postoperative
Interventions: OTHER: Peppermint oil aromatherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Double-Blind, Randomized, Dose Ranging Study of Alferon LDO (Low Dose Oral Interferon Alfa-n3 (Human Leukocyte Derived)) in HIV+ Subjects
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Interferon alfa-n3
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: SKOLKONTAKT - Social Skills Training in a School Setting
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Attention Deficit Hyperactivity Disorder|Anxiety|Depression
Interventions: BEHAVIORAL: SKOLKONTAKT|BEHAVIORAL: Social activity group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Swallowing Difficulties With Medication Intake and Coping Strategies in Patients With Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis|Deglutition Disorders|Adherence to Medication Regime|Coping Behaviour|Scleroderma, Systemic
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ofatumumab Bendamustine Combination Compared With Bendamustine Monotherapy in Indolent B-cell NHL Unresponsive to Rituxtherapy
Status: TERMINATED
Conditions: Lymphoma, Follicular
Interventions: DRUG: Ofatumumab|DRUG: Bendamustine infusion|DRUG: Ofatumumab and Bendamustine infusions (Arm A)|DRUG: Bendamustine infusion (Arm B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I, Dose-finding Study of BEZ235 in Adult Patients With Relapsed or Refractory Acute Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Leukemia, Myelocytic, Acute|Chronic Myelogenous Leukemia With Crisis of Blast Cells
Interventions: DRUG: BEZ235
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Transcranial Direct-current Stimulation in Attentional Performance and Pain in Patients With Fibromyalgia
Status: UNKNOWN
Conditions: Fibromyalgia
Interventions: DEVICE: Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: A Study of Xeloda (Capecitabine) Plus Radiotherapy in Participants With Locally Advanced Rectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: RADIATION: Standard radiotherapy|DRUG: Capecitabine [Xeloda]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trans-incisional Quadratus Lumborum Block Versus Caudal Analgesia in Pediatric Open Renal Surgeries.
Status: COMPLETED
Conditions: Anesthesia
Interventions: PROCEDURE: Trans-incisional Quadratus lumborum block|PROCEDURE: Caudal block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Methods to Increase HIV Testing, Access to HIV Care, and HIV Prevention Strategies
Status: COMPLETED
Conditions: HIV Infection
Interventions: BEHAVIORAL: Linkage-to-Care Component: Financial Incentive (FI)|BEHAVIORAL: Linkage-to-Care Component: Standard of Care (SOC)|BEHAVIORAL: Viral Suppression Component: FI|BEHAVIORAL: Viral Suppression Component: SOC|BEHAVIORAL: Prevention for Positives Component: Counseling and SOC|BEHAVIORAL: Prevention for Positives Component: SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reversibility of Apixaban Anticoagulation With the Four Factor Prothrombin Complex Concentrate Kcentra
Status: COMPLETED
Conditions: Thrombosis
Interventions: DRUG: Kcentra|DRUG: Apixaban|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fluid Therapy and Glycocalyx Shedding During Moderate Surgery
Status: RECRUITING
Conditions: Abdominoplasty
Interventions: OTHER: Lactated Ringer's Fluid Bolus Response to Low Urinary Output|OTHER: Post-Anesthesia Care Unit Lactated Ringer's Fluid Management Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Hyaluronic Acid on Oral Mucosal Wound Healing - Focus on Pain and Re-epithelisation
Status: COMPLETED
Conditions: Soft Tissue Wound Healing
Interventions: PROCEDURE: palatal soft tissue harvesting|DEVICE: Hyaluronic acid|OTHER: Saline solution (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Auriclosene Irrigation Solution on Urinary Catheter Patency
Status: UNKNOWN
Conditions: Urinary Catheter Blockage and Encrustation
Interventions: DRUG: Auriclosene Irrigation Solution, 0.2%|DRUG: Auriclosene Vehicle Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Darbepoetin for Ischemic Neonatal Stroke to Augment Regeneration
Status: RECRUITING
Conditions: PAIS|Neonatal Stroke|Perinatal Stroke
Interventions: DRUG: Darbepoetin Alfa|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Pain Alleviation in Open Heart Surgery
Status: COMPLETED
Conditions: Open Heart Surgery|Postoperative Pain
Interventions: DRUG: bupivacain with magnesium sulphate|DRUG: Bupivacaine only|DRUG: conventional
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: LOTCOL Study: Local Treatment of Colo-rectal Liver Met
Status: TERMINATED
Conditions: Metastatic Colo-rectal Cancer
Interventions: PROCEDURE: Radiofrequency ablation, microwave, radiation therapy|DRUG: Standard Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigation of N-acetylcysteine and Fenoldopam as Renal Protection Agents for Cardiac Surgery
Status: COMPLETED
Conditions: Kidney Failure, Acute|Kidney Failure, Chronic|Cardiac Surgical Procedures
Interventions: DRUG: N-acetylcysteine|DRUG: fenoldopam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Hip Fracture Exparel Administration Trial Capsule During Hemiarthroplasty
Status: COMPLETED
Conditions: Intracapsular Fracture of Femur|Femoral Neck Fractures|Hip Hemiarthroplasty
Interventions: DRUG: Bupivacaine liposome|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate Mycobacterium w in Preventing COVID-19 in Subjects at Risk of Getting Infected With COVID-19
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Suspension of heat killed (autoclaved) Mycobacterium w|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combined CABG and Stem-Cell Transplantation for Heart Failure
Status: UNKNOWN
Conditions: Heart Failure|Myocardial Infarction|Coronary Artery Disease
Interventions: PROCEDURE: Coronary bypass operation|PROCEDURE: Bone marrow aspiration (crista iliaca)|BIOLOGICAL: Intramyocardial mesenchymal stem cell transplantation|BIOLOGICAL: Intramyocardial injection of autologous serum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Cerebellar Stimulation on Motor Learning
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: tDCS|DEVICE: tDCS|DEVICE: tDCS|DEVICE: rTMS|DEVICE: rTMS|DEVICE: rTMS|DEVICE: pp-TMS assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Course and Effectiveness of Conservative Therapy in Patients With Achilles Tendinopathy
Status: ENROLLING_BY_INVITATION
Conditions: Achilles Tendinopathy
Interventions: DEVICE: BTL-6000 FSWT|OTHER: Achilles Tendon Loading Exercise Protocol According to Silbernagel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Effects of Sucontral(TM) on Mild and Moderate Cases of Diabetes Mellitus (Type 2)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Extract from Hintonia latiflora bark
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Intratumoral IL12 Plasmid Electroporation in Cutaneous Lymphoma
Status: TERMINATED
Conditions: Cutaneous T Cell Lymphomas (CTCL)|Mycosis Fungoides (MF)
Interventions: BIOLOGICAL: Tavokinogene Telseplasmid (tavo)|DEVICE: OncoSec Medical System (OMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Analysis of Two Therapeutic Strategies in Patients With Spondyloarthritis Treated With Anti-tnf Biologics
Status: TERMINATED
Conditions: Spondyloarthritis
Interventions: BIOLOGICAL: anti drug antibodies dosage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: At-home Testing Refraction Results With Best Corrected Visual Acuity (BCVA) Outcomes in Adults
Status: COMPLETED
Conditions: Visual Impairment|Myopia|Hyperopia|Astigmatism
Interventions: DEVICE: With Try-on glasses
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of APG-2575 in Combination With Azacitidine in Patients With Acute Myeloid Leukemia (AML)
Status: RECRUITING
Conditions: AML, Adult
Interventions: DRUG: APG 2575 ramp up arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility of Indocyanine Green Fluorescence for Intraoperative Assessment of Intestinal Perfusion in Young Infants and Neonates
Status: NOT_YET_RECRUITING
Conditions: NEC|Atresia|Malrotation|Intestinal Perforation
Interventions: DEVICE: Perfusion assessment by means of the SPY-PHI camera
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluating Outcomes for Youth Receiving Hospital-based Violence Prevention With and Without a Community-level Initiative
Status: TERMINATED
Conditions: Violence in Adolescence
Interventions: BEHAVIORAL: Bridging the Gap|OTHER: Communities that Care (CTC)|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study Evaluating the Effect of Carvedilol in Patients With Active Rheumatoid Arthritis
Status: NOT_YET_RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Carvedilol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Postoperative Sequence Chemoradiotherapy Compared With Chemotherapy Alone for Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: RADIATION: sequence chemoradiotherapy|DRUG: chemotherapy alone following radical resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Homeopathic Treatment for Depression in Peri- and Postmenopausal Women
Status: COMPLETED
Conditions: Moderate Depression|Menopausal and Postmenopausal Disorders
Interventions: DRUG: Individualized homeopathic treatment|DRUG: Fluoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Forced Aerobic Exercise for Stroke Rehabilitation
Status: COMPLETED
Conditions: Stroke
Interventions: BEHAVIORAL: Forced Exercise & Upper Extremity Repetitive Task Practice|BEHAVIORAL: Voluntary Exercise & Upper Extremity Repetitive Task Practice|BEHAVIORAL: Stroke Education & Upper Extremity Repetitive Task Practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Virtual Reality and Motor Imagery Applications in Patients With Ankle Instability
Status: NOT_YET_RECRUITING
Conditions: Ankle Sprains
Interventions: OTHER: Conventional physiotherapy program|OTHER: Virtual reality (VR)|OTHER: Motor imagery (MI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of PET/CT to Evaluate Synovitis in the Temporomandibular Joint (TMJ)
Status: WITHDRAWN
Conditions: Temporomandibular Joint|Conservative Treatment Therapy
Interventions: DRUG: PET/CT with 18-FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: EB-101 Treatment for New and Previously Treated Patients With Recessive Dystrophic Epidermolysis Bullosa (RDEB)
Status: RECRUITING
Conditions: Epidermolysis Bullosa|Recessive Dystrophic Epidermolysis Bullosa|RDEB
Interventions: BIOLOGICAL: EB-101 Surgical application of RDEB wounds
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of a Screening Tool for Swallowing Disorders for the Elderly
Status: RECRUITING
Conditions: Swallowing Disorder|Dysphagia
Interventions: DIAGNOSTIC_TEST: Deglut'G test|DIAGNOSTIC_TEST: SLP swallowing test|DIAGNOSTIC_TEST: ENT doctor swallowing test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ferric Carboxymaltose (FCM) Assessment in Subjects With Iron Deficiency Anaemia and Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD)
Status: COMPLETED
Conditions: Iron Deficiency Anaemia|Chronic Kidney Disease
Interventions: DRUG: FCM (Ferric carboxymaltose) high ferritin target|DRUG: FCM (Ferric carboxymaltose) low ferritin target|DRUG: Oral Iron (Ferrous sulphate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Managing Fear of Cancer Progression Metacognition-based Vs Supportive-expressive Based Approaches
Status: RECRUITING
Conditions: Advanced or Metastatic Cancer|Fear of Cancer Progression|Metacognition-based Intervention|Supportive-expressive Based Intervention|Psychooncology
Interventions: BEHAVIORAL: ConquerFear intervention|BEHAVIORAL: CALM intervention|BEHAVIORAL: Basic Cancer Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementing a Virtual Tobacco Treatment for Cancer Patients in Community Oncology Practices
Status: COMPLETED
Conditions: Carcinoma In Situ|Current Smoker|Malignant Neoplasm|Primary Neoplasm|Recurrent Neoplasm
Interventions: OTHER: Behavioral, Psychological or Informational Intervention|DRUG: Nicotine Replacement|OTHER: Quality-of-Life Assessment|OTHER: Survey Administration|OTHER: Tobacco Cessation Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: 89Zr-TLX250 for PET/CT Imaging of ccRCC- ZIRCON Study
Status: COMPLETED
Conditions: Clear Cell Renal Cell Carcinoma
Interventions: DIAGNOSTIC_TEST: 89Zr-girentuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Visual Outcomes for Toric Efficacy Study
Status: COMPLETED
Conditions: Astigmatism|Myopia
Interventions: DEVICE: Contact lenses (Orthokeratology)|DEVICE: Contact lenses (Soft Multifocal)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Targeted Blood-pressure Management and Acute Kidney Injury After Coronary Artery Bypass Surgery
Status: RECRUITING
Conditions: Coronary Artery Bypass, Off-Pump|Intraoperative Hypotension|Acute Kidney Injury|Preventive Medicine|Intraoperative Care
Interventions: DRUG: Targeted blood-pressure management|DRUG: Routine blood-pressure management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Landiolol for Prevention of Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
Status: UNKNOWN
Conditions: Atrial Fibrillation|Postoperative Complications
Interventions: DRUG: Landiolol HCl|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nebulized N-Acetyl Cysteine for Bronchiolitis in Inpatient Hospital Use
Status: UNKNOWN
Conditions: Bronchiolitis Acute
Interventions: DRUG: N-Acetyl Cysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: High-Dose PEG-Intron Pharmacokinetic Study in Patients With Melanoma (Study P04831 AM2)
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: PEG-Intron
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 68Ga-DOTATOC PET for the Evaluation of Gastroenteropancreatic Neuroendocrine Tumours
Status: RECRUITING
Conditions: Gastroenteropancreatic Neuroendocrine Tumor
Interventions: DIAGNOSTIC_TEST: 68Ga-DOTATOC PET as a part of their clinical diagnostic work-up will be included
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exploring Relevant Immune-based Biomarkers and Circulating Tumor Cells During Treatment With Immunotherapy in Genitourinary Malignancies (CTC Immune Based Biomarkers)
Status: RECRUITING
Conditions: Carcinoma, Renal Cell|Carcinoma, Urothelial
Interventions: DEVICE: Immune cell and CTC detection procedures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TisaGenlecleucel in Elderly Patients With First-Relapsed or Primary Refractory Aggressive B-cell Non-Hodgkin Lymphoma
Status: TERMINATED
Conditions: Non Hodgkin Lymphoma
Interventions: DRUG: CTL019
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi Point Pacing vs. Conventional STUDY PROTOCOL
Status: WITHDRAWN
Conditions: Compare Two Programming Modalities for CRT Devices in Heart Failure Patients With an Indication for Cardiac Resynchronization Therapy
Interventions: DEVICE: conventional CRT|DEVICE: MPP CRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Tobacco Treatment Medical Education in 10 Medical Schools
Status: COMPLETED
Conditions: Tobacco Use Disorder|Smoking Cessation
Interventions: BEHAVIORAL: Web-based curriculum on tobacco dependence treatment|BEHAVIORAL: Tobacco Counseling Role Play|BEHAVIORAL: Preceptor Training and Teaching Medical Students|BEHAVIORAL: Booster Session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Dupilumab on Lung Inflammation and Related Changes in Airway Volumes Detectable by Functional Respiratory Imaging in Patients With Moderate-severe Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Dupilumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endothelial Dysfunction in Resuscitated Cardiac Arrest
Status: COMPLETED
Conditions: Cardiac Arrest
Interventions: DRUG: Iloprost|DRUG: Saline|DEVICE: Phillips M1006B, offset by -10mmHg|DEVICE: Philips M1006B, No offset
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tailoring Therapy in Post-surgical Patients With Low-risk Endometrial Cancer
Status: RECRUITING
Conditions: Stage I Uterine Corpus Endometrial Stromal Sarcoma AJCC v8|Stage II Uterine Corpus Endometrial Stromal Sarcoma AJCC v8|Stage III Uterine Corpus Endometrial Stromal Sarcoma AJCC v8
Interventions: OTHER: Clinical Observation|PROCEDURE: Computed Tomography|RADIATION: External Beam Radiation Therapy|PROCEDURE: High-Dose-Rate Vaginal Brachytherapy|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|OTHER: Questionnaire Administration|PROCEDURE: X-Ray Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid Treatment and Recovery Through a Safe Pain Management Program
Status: COMPLETED
Conditions: Depression|Opioid Use|Chronic Pain|Anxiety
Interventions: BEHAVIORAL: Electronic medical recorded clinical decision support [EMR CDS]|BEHAVIORAL: Stepped opioid collaborative care model [CCM]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pentostatin, Alemtuzumab, and Rituximab in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: BIOLOGICAL: alemtuzumab|BIOLOGICAL: rituximab|DRUG: pentostatin|DRUG: sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Group Cognitive Behavioral Therapy (CBT I) Vs. Quetiapine for Residual Insomnia Impairing Recovery Among Elderly With Stable Major Affective Disorders
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: Quetiapine|BEHAVIORAL: Cogntive behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perineal Massage Performed During the Labour
Status: COMPLETED
Conditions: Delivery Problem|Childrearing|Satisfaction, Patient|Perineum; Injury|Perineal Tear|Pain, Labor
Interventions: OTHER: Perinal massage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TrAnsCatHeter Intravascular Ultrasound Energy deliVery for rEnal Denervation (ACHIEVE)
Status: COMPLETED
Conditions: Resistant Hypertension
Interventions: DEVICE: PARADISE percutaneous renal denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Pharmacokinetics and Pharmacodynamics of Insulin Lispro Mix 25 to Humalog® Mix 25 in Healthy Subjects
Status: COMPLETED
Conditions: Clamp Study
Interventions: DRUG: Insulin Lispro Mix 25|DRUG: Humalog® Mix 25
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Anakinra to Prevent Adverse Post-infarction Remodeling (2)
Status: COMPLETED
Conditions: Acute Myocardial Infarction|Heart Failure
Interventions: DRUG: Anakinra|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of COVID-19 Vaccine, Inactivated in Healthy Population Aged From 3 to 11 Years
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: COVID-19 Vaccine,Inactivated
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparative Evaluation of Osseodensification Versus Conventional Implant Site
Status: COMPLETED
Conditions: Bone Density|Implant Stability
Interventions: PROCEDURE: osseodensification protocol|PROCEDURE: conventional implant site preparation protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: R-CDOP Combined With Intrathecal Methotrexate for DLBCL Patients With High-risk of CNS Relapse
Status: RECRUITING
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: R-CDOP+intrathecal MTX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Irinotecan/Bevacizumab Association for Naive Unresectable Glioblastoma
Status: COMPLETED
Conditions: Naive Unresectable Glioblastoma
Interventions: DRUG: Avastin + Campto / radiotherapy + Temodal + Avastin (4 cures)|DRUG: Temodal/radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cortisol Augmentation of a Psychological Treatment in Warfighters With Post Traumatic Stress Disorder (PTSD)
Status: UNKNOWN
Conditions: PTSD
Interventions: BEHAVIORAL: Prolonged Exposure therapy|DRUG: Hydrocortisone|BEHAVIORAL: Prolonged Exposure therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gene Therapy for Fanconi Anemia
Status: TERMINATED
Conditions: Fanconi Anemia
Interventions: PROCEDURE: Bone Marrow Aspiration|BIOLOGICAL: Filgrastim|BIOLOGICAL: Genetically Engineered Hematopoietic Stem Progenitor Cells|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Leukapheresis|DRUG: Methylprednisolone|DRUG: Plerixafor|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Montelukast for Maintenance Therapy of Eosinophilic Esophagitis in Children
Status: TERMINATED
Conditions: Eosinophilic Esophagitis
Interventions: DRUG: Montelukast|OTHER: placebo|DRUG: 5 mg Montelukast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nasal Continuous Positive Airway Pressure (CPAP) in Chronic Fatigue and Sleep-disordered Breathing
Status: TERMINATED
Conditions: Chronic Fatigue With OSA|Chronic Fatigue Syndrome With OSA
Interventions: PROCEDURE: Active CPAP is compared with sham CPAP as a control intervention.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Intensive Adherence Counselling Among People Living With HIV/AIDS With Low-level Viraemia in Uganda.
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV/AIDS
Interventions: PROCEDURE: Intensive Adherence Counselling (IAC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Value of Preoperative Diagnosis and Prognostic Prediction Based on Radiomics of Giant Cell Tumor of Spine
Status: COMPLETED
Conditions: Spinal Tumor
Interventions: DIAGNOSTIC_TEST: RANK/RANKL(RANK: Receptor Activator of Nuclear factor Kappa-Β /RANKL:Receptor Activator of Nuclear factor Kappa-Β Ligand)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Docetaxel and Prednisolone With or Without Zoledronic Acid and/or Strontium Chloride Sr 89 in Treating Patients With Prostate Cancer Metastatic to Bone That Has Not Responded to Hormone Therapy
Status: COMPLETED
Conditions: Metastatic Cancer|Prostate Cancer
Interventions: DRUG: docetaxel|DRUG: prednisolone|DRUG: zoledronic acid|PROCEDURE: quality-of-life assessment|RADIATION: strontium chloride Sr 89
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Developing and Testing Drone-Delivered AEDs for Cardiac Arrests In Rural America
Status: NOT_YET_RECRUITING
Conditions: Cardiac Arrest|Sudden Cardiac Arrest
Interventions: OTHER: DFR AED Pilot Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH