pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Effect of Upper Limb Loading During Partial Body Weight Support Treadmill Training in Children With Cerebral Palsy
Status: UNKNOWN
Conditions: Cerebral Palsy
Interventions: OTHER: Upper limb loading
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Discomfort Evaluation During Atraumatic Restorative Treatment in Children
Status: COMPLETED
Conditions: Dental Caries|Primary Teeth|Post Dental Restoration
Interventions: OTHER: Caries removal using only manual instruments|OTHER: Caries removal using Papacarie gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Follicle Stimulating Hormone (FSH) to Improve Testicular Development in Men With Hypogonadism
Status: TERMINATED
Conditions: Hypogonadism|Kallmann Syndrome
Interventions: PROCEDURE: Testicular biopsy|DRUG: gonadotropin releasing hormone (GnRH)|DRUG: follicle stimulating hormone (FSH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Daytime Corneal Swelling During Wear of Narafilcon B Lenses
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: narafilcon B|DEVICE: Polymacon|DEVICE: Lotrafilcon A|OTHER: Spectacles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Diagnostic in Assessment of Risk HDS and HCT in Patients With Haemoblasts.
Status: RECRUITING
Conditions: Cardiotoxicity
Interventions: DIAGNOSTIC_TEST: electrocardiography, echocardiography with the determination of global longitudinal strain, cardiopulmonary exercise test, and diagnostic of endothelial function by Angioscan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Traditional Chinese Medicine for Complications in Critically Ill Patients
Status: UNKNOWN
Conditions: Critically Ill Patients
Interventions: OTHER: Chinese herbal medicine decoction、Acupuncture or Laser acupuncture pen treatment、Acupoint Tuina massage、Acupoint application、Nursing/Diet and health education and guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MIrabegron and Physiological Function in Cold Environments
Status: COMPLETED
Conditions: Resting Energy Expenditure|Thermogenesis|Brown Adipose Tissue
Interventions: DRUG: Mirabegron|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination Chemotherapy With or Without Sodium Thiosulfate in Preventing Low Platelet Count While Treating Patients With Malignant Brain Tumors
Status: UNKNOWN
Conditions: Malignant Glioma
Interventions: DRUG: Carboplatin|DRUG: Cyclophosphamide|DRUG: Etoposide Phosphate|OTHER: Quality-of-Life Assessment|DRUG: Sodium Thiosulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Of PF-03882845 Absorption In Healthy Volunteers Given Orally As Tablet Versus Suspension Formulations And Effect Of Food On Its Absorption
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: PF-03882845|DRUG: PF-03882845|DRUG: PF-03882845
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bioavailability of Different Formulas Enriched With DHA Using Wet Mixing or Dry Blending Method
Status: RECRUITING
Conditions: Healthy Children
Interventions: DIETARY_SUPPLEMENT: DHA Wet Mixing method|DIETARY_SUPPLEMENT: DHA Dry Blending Method|DIETARY_SUPPLEMENT: Fish Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate Safety of Multiple Dose of ASP0456 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy|Pharmacokinetics of ASP0456
Interventions: DRUG: ASP0456|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Non-analgesic Effects Produced by Equipotent Analgesic Doses of Sufentanil, Hydromorphone, and Oxycodone
Status: COMPLETED
Conditions: Opioid Use
Interventions: DRUG: Sufentanil|DRUG: Hydromorphone|DRUG: Oxycodone|DRUG: normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dutasteride for the Reduction of Alcohol Use in Male Drinkers
Status: COMPLETED
Conditions: Alcoholism|Alcohol Abuse|Alcohol Dependence
Interventions: DRUG: Dutasteride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Cesarean Section Niche in Women With Unexplained Abnormal Uterine Bleeding
Status: COMPLETED
Conditions: Cesarean Section; Dehiscence|Abnormal Uterine Bleeding
Interventions: DEVICE: Office Hysteroscope
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: CONCERTA Lab School Study
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: CONCERTA (methylphenidate HCl) or placebo|DRUG: CONCERTA (methylphenidate HCl) or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Determine the Tolerability and Safety of Atovaquone-proguanil (ATV-PG) Co-administered With Amodiaquine (AQ)
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: ATV-PG 1000-400 mg + AQ 612 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Additional Treatment for Isolated Local Pancreatic Cancer Recurrence Using Stereotactic Body Radiation Therapy
Status: ENROLLING_BY_INVITATION
Conditions: Recurrent Pancreatic Ductal Adenocarcinoma
Interventions: RADIATION: Additional stereotactic body radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Advanced Glycation End Products and Dietary Intervention in Polycystic Ovary Patients
Status: ENROLLING_BY_INVITATION
Conditions: Polycystic Ovary Syndrome|Diet Habit
Interventions: BEHAVIORAL: Low AGE diet with reduced energy and fat|BEHAVIORAL: Energy and fat-reduced normal diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigating the Effect of Stochastic Resonance Vibration on Gait and Balance and Upper Extremity Function in Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: DEVICE: Stochastic resonance (SR) wraps
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Antibiotic Prophylaxis in Orthopaedic Traumatology
Status: COMPLETED
Conditions: Fractures, Closed|Wounds and Injuries
Interventions: DRUG: cefazolin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single-Dose Clinical Pharmacology Study in Asthmatic Adolescent and Adult Patients
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Test treatments CHF 1535 100/6 pMDI (Foster®) TEST1|DRUG: CHF 1535 100/6 pMDI (Foster®) using AeroChamber Plus™ (TEST 2).|DRUG: BDP pMDI 100 µg (Qvar®) plus formoterol fumarate pMDI 6 µg (Atimos®) (REF)|DRUG: CHF 1535 100/6 pMDI (Foster®) (CTR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Manual and Mechanical Chest Compression During In-hospital Witnessed Cardiac Arrests Using Cerebral Oximetry
Status: COMPLETED
Conditions: Cardiopulmonary Resuscitation
Interventions: DEVICE: Mechanical chest compression|OTHER: Manuel chest compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of Bimatoprost 0.03% Solution for the Treatment of Thinning Eyebrows
Status: COMPLETED
Conditions: Hypotrichosis
Interventions: DRUG: Track A|DRUG: Track B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adding Bismuth to Rabeprazole-based First-line Triple Therapy Does Not Improve the Eradication of Helicobacter Pylori
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: RAK therapy|DRUG: RBAK therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of High-Dose Cyclophosphamide in Patients With Severe Autoimmune Hematologic Disease
Status: COMPLETED
Conditions: Anemia, Hemolytic, Autoimmune|Felty Syndrome|Purpura, Thrombocytopenic|Autoimmune Diseases
Interventions: DRUG: cyclophosphamide|DRUG: filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Remimazolam With Protocolized Sedation on Critical Ill, Mechanical Ventilated Patients Compared With Midazolam
Status: RECRUITING
Conditions: Sedation and Analgesia
Interventions: DRUG: Remimazolam|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Glycemic Control and Complications in Diabetes Mellitus Type 2 (VADT)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Insulin|DRUG: Glimepiride|DRUG: Rosiglitazone|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amlodipine Plus/Minus Atorvastatin for Protection of Arteries
Status: UNKNOWN
Conditions: Arterial and Arteriolar Disorders
Interventions: DRUG: amlodipine plus atorvastatin (Caduet)|DRUG: amlodipine (Norvasc)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-arm, Open-label Study of Olverembatinib, CD3/CD19 Bispecific T-cell Engager, and Chidamide in Patients With Newly Diagnosed Ph+ALL
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Philadelphia Chromosome|Philadelphia-Positive ALL|Adult ALL|IKZF1 Gene Mutation
Interventions: DRUG: Prednisone, Olverembatinib, Blinatumomab, Chidamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cabometyx and Avelumab in Patients With Metastatic Renal Cell Carcinoma (mRCC)
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Avelumab|DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A/H5N1/LT Dose Ranging Study
Status: COMPLETED
Conditions: Pandemic Influenza
Interventions: BIOLOGICAL: A/H5N1|BIOLOGICAL: A/H5N1|BIOLOGICAL: LT Adjuvant Patch|BIOLOGICAL: LT Adjuvant Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eculizumab to Prevent Antibody-mediated Rejection in ABO Blood Group Incompatible Living Donor Kidney Transplantation
Status: TERMINATED
Conditions: Kidney Transplant
Interventions: DRUG: Eculizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotic Ingestion and Isoagglutinin Titers
Status: COMPLETED
Conditions: Isoagglutinin-Mediated Hemolysis|Probiotic Toxicity
Interventions: DIETARY_SUPPLEMENT: Probiotic Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Randomized Controlled Trial of Ultrasound-guided Versus Landmark Technique for Peripherally Inserted Central Catheter (PICC) Placement
Status: COMPLETED
Conditions: PICC Placement
Interventions: PROCEDURE: PICC Placement by Landmark Technique|PROCEDURE: PICC Placement by Ultrasound-guided Technique|DEVICE: Ultrasound Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: High Purity Type I Collagen Based Skin Substitute Vs Dehydrated Human Amnion/Chorion Membrane in Treatment of DFUs
Status: RECRUITING
Conditions: Diabetic Foot Ulcer (DFU)
Interventions: DEVICE: SOC and Type-I Collagen-based Skin Substitute|OTHER: SOC and Human Amnion/Chorion Membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post Marketing Observational Study on Safety of BALFAXAR vs. KCENTRA for Reversal of Vitamin K Antagonist Induced Anticoagulation in Adults Undergoing Urgent Surgery or Invasive Procedure
Status: NOT_YET_RECRUITING
Conditions: Vitamin K-Dependent Coagulation Defect|Significant Bleeding Risk
Interventions: DRUG: Balfaxar|DRUG: Kcentra
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Study Between Nebulised Dexmedetomidine and Nebulised Midazolam in Children Undergoing Lower Abdominal Surgeries
Status: COMPLETED
Conditions: Emergence Delirium|Anxiety Preoperative
Interventions: DRUG: Nebulised Dexmeditomidine|DRUG: Nebulised Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study To Determine Bioavailability of Sotagliflozin in Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Healthy Subjects
Interventions: DRUG: Sotagliflozin (SAR439954)|DRUG: 14C-microtracer|DRUG: Charcoal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electronic Health Record Strategies to Promote Diverse Participation in Research AIM 2
Status: NOT_YET_RECRUITING
Conditions: Patient Participation
Interventions: OTHER: Traditional Letter|OTHER: Direct to Patient Message|OTHER: Optimized Letter|OTHER: Direct to Patient Message - Optimized
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The DOMINO Trial: Diet Or Medication in Irritable Bowel syNdrOme
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: OTHER: IBS Diet|DRUG: Otilonium Bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Zero-Time Exercise (ZTEx) on Inactive Adults With Insomnia Disorder
Status: COMPLETED
Conditions: Insomnia, Primary
Interventions: OTHER: Zero Time Exercise|OTHER: Sleep hygiene education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Nelfinavir and Efavirenz, Used Alone or Together, Combined With Other Anti-HIV Drugs in Patients Who Have Taken Anti-HIV Drugs
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Ritonavir|DRUG: Nelfinavir mesylate|DRUG: Efavirenz|DRUG: Levocarnitine|DRUG: Adefovir dipivoxil|DRUG: Saquinavir|DRUG: Lamivudine|DRUG: Stavudine|DRUG: Zidovudine|DRUG: Zalcitabine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of AK105 With Anlotinib and Radiotherapy Adjuvant Therapy in MGMT Unmethylated Newly Diagnosed Glioblastoma.
Status: UNKNOWN
Conditions: MGMT-Unmethylated Glioblastoma
Interventions: DRUG: Anlotinib|DRUG: AK105|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PSV Versus ASV With Intellisync Mode for Delivery of NIV in AECOPD
Status: RECRUITING
Conditions: COPD Exacerbation Acute|COPD Exacerbation
Interventions: PROCEDURE: PSV mode during NIV|PROCEDURE: ASV intellisync
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TPIV100 and Sargramostim for the Treatment of HER2 Positive, Stage II-III Breast Cancer in Patients With Residual Disease After Chemotherapy and Surgery
Status: RECRUITING
Conditions: Breast Adenocarcinoma|Stage II Breast Cancer AJCC v6 and v7|Stage IIA Breast Cancer AJCC v6 and v7|Stage IIB Breast Cancer AJCC v6 and v7|Stage III Breast Cancer AJCC v7|Stage IIIA Breast Cancer AJCC v7|Stage IIIB Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7
Interventions: BIOLOGICAL: Multi-epitope HER2 Peptide Vaccine TPIV100|BIOLOGICAL: Pertuzumab|OTHER: Placebo Administration|BIOLOGICAL: Sargramostim|BIOLOGICAL: Trastuzumab|BIOLOGICAL: Trastuzumab Emtansine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and Efficacy of MHV370 in Participants With Sjogren's Syndrome (SjS) or Mixed Connective Tissue Disease (MCTD)
Status: TERMINATED
Conditions: Sjogren Syndrome|Mixed Connective Tissue Disease
Interventions: DRUG: MHV370|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: YAZ Premenstrual Dysphoric Disorder (PMDD) in China
Status: COMPLETED
Conditions: Premenstrual Dysphoric Disorder ( PMDD)
Interventions: DRUG: EE20/DRSP(YAZ, BAY86-5300)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lumbar Degenerative Disc Disease Treated With Anterior Tension Band System (ATB) With ALIF/FRA Spacer
Status: COMPLETED
Conditions: Lumbar Degenerative Disc Disease
Interventions: DEVICE: Interbody Fusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect Of Different Lining Materials in Stepwise Excavation
Status: UNKNOWN
Conditions: Dental Pulp Necrosis
Interventions: DRUG: Control|DRUG: Calcium Hydroxide|DRUG: Mineral Trioxide Aggregate(MTA)|DRUG: CEM cement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects of PER977 Following Heparin
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PER977|DRUG: Placebo|DRUG: Heparin Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Safety and Tolerability Study of COVA322 in Patients With Stable Chronic Moderate-to-severe Plaque Psoriasis
Status: TERMINATED
Conditions: Plaque Psoriasis
Interventions: DRUG: COVA322|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Improvement in Insulin Secretion and Decrease in HbA1c in GLP-1 RA Therapy in T2DM Patients
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: GLP-1 receptor agonist
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Paracetamol or Morphine for the Treatment of Acute Flank Pain
Status: COMPLETED
Conditions: Urolithiasis
Interventions: DRUG: paracetamol|DRUG: morphine|DRUG: Paracetamol|DRUG: Paracetamol|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Non-inferiority of Belotero® Basic Versus Juvéderm® Ultra 3
Status: COMPLETED
Conditions: Physiological Stress|Disorder of Aging|Skin Diseases|Wrinkles|Nasolabial Folds
Interventions: DEVICE: Hyaluronic Acid Filler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Local Sodium Hypochlorite Gel in Non Surgical Periodontal Debridement
Status: COMPLETED
Conditions: Periodontal Diseases
Interventions: DRUG: Sodium hypochlorite gel application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Safety and Efficacy Study of OPTIVE FUSION™ With VISMED® Multi for the Management of Dry Eye
Status: COMPLETED
Conditions: Dry Eye Syndromes|Keratoconjunctivitis Sicca
Interventions: DRUG: carboxymethylcellulose 0.5%/glycerin 0.9%|DRUG: sodium hyaluronate 0.18%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neural Therapy and Kinesio Taping Effectiveness in Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: OTHER: Neural Therapy|OTHER: Kinesio taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Autonomy and Perceptions on Resistance Training Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Strength Training
Interventions: OTHER: Autonomy and Perceptions Approach to Resistance Training (APART)|OTHER: Standard prescription
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Multicentric, Open Label With Retrospective Inclusion and Follow-up of Acetabular Prothetic Implant "Polymax"
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: OTHER: Early complications data|OTHER: Late stage complications data|OTHER: Patient Satisfaction|OTHER: Efficacity|OTHER: Radiographic evaluation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Safety and Efficacy of Micro-energy Ultrasound Therapy in the Treatment of Female Stress Urinary Incontinence
Status: UNKNOWN
Conditions: Female Stress Urinary Incontinence
Interventions: DEVICE: LIPUS-1|DEVICE: LIPUS-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Changkang Granule in the Treatment of Diarrhea-predominant Irritable Bowel Syndrome (IBS-D)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome with Diarrhea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Dasatinib in Patients With Chronic Myelogenous Leukemia Who Are Resistant or Intolerant of Imatinib Mesylate
Status: COMPLETED
Conditions: Leukemia, Myeloid, Chronic|Leukemia, Lymphocytic, Acute, L2
Interventions: DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Cancer Screening Among Medicaid Recipients in Minnesota
Status: COMPLETED
Conditions: Colorectal Cancer|Breast Cancer
Interventions: BEHAVIORAL: Mammography direct mail coupled with a financial incentive|BEHAVIORAL: Usual care|BEHAVIORAL: Colonoscopy direct mail coupled with a financial incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Selegiline and Reward Processing
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: Selegiline Hydrochloride 10 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Electrical Stimulation After Botulinum Toxin Injections to the Upper Extremity
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: Neuromuscular Electrical Stimulation|DEVICE: Sham Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Er,Cr:YSGG and Diode Lasers in the Treatment of Peri-implantitis
Status: COMPLETED
Conditions: Peri-Implantitis
Interventions: DEVICE: Traditional non surgical mechanical therapy|DEVICE: Diode laser assisted non-surgical mechancal therapy|DEVICE: Er, Cr: YSGG laser-assisted non-surgical mechanical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Swiss Versus Standard Low Back Acupuncture in Patients With Chronic Low Back Pain
Status: RECRUITING
Conditions: Chronic Low-back Pain
Interventions: OTHER: Swiss low back acupuncture (SLBA)|OTHER: Standard acupuncture (SA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lysergic Acid Diethylamide (LSD)-Assisted Psychotherapy in People With Illness-related Anxiety
Status: COMPLETED
Conditions: Anxiety
Interventions: DRUG: 200 mcg LSD|DRUG: 20 mcg LSD|BEHAVIORAL: Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute and Chronic Effects of Ecologic Barrier© on Mood and Cognition
Status: COMPLETED
Conditions: Cognitive Change|Mood
Interventions: DIETARY_SUPPLEMENT: Ecologic Barrier©|DIETARY_SUPPLEMENT: Placebo powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Different Limb Lengths in Gastric Bypass Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity, Morbid|Diabetes Mellitus, Type 2|Hypertension|Dyslipidemias|Sleep Apnea
Interventions: PROCEDURE: Long BPL LRYGB|PROCEDURE: Short BPL LRYGB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prognostic Role of Free Psa Ratio at Biochemical Recurrence After Radical Treatments for Prostate Cancer
Status: COMPLETED
Conditions: Metastasis|Castration-resistant Prostate Cancer|Death
Interventions: DIAGNOSTIC_TEST: Free PSA ratio test in patients after definitive treatment for localized prostate cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exploratory Efficacy of N-Acetylcysteine in Patients With History of COVID-19
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: DRUG: N-Acetylcysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Schema Therapy for Patients With Chronic Treatment Resistant Depression
Status: RECRUITING
Conditions: Treatment Resistant Depression|Chronic Depression
Interventions: BEHAVIORAL: Schema therapy|BEHAVIORAL: Other psychotherapy|OTHER: Standard care package content
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Comparison of Different Adhesives in NCCLs
Status: ACTIVE_NOT_RECRUITING
Conditions: Tooth Wear
Interventions: DEVICE: Clearfil Universal Bond Quick|DEVICE: Clearfil Universal Bond Quick|DEVICE: Clearfil Universal Bond Quick|DEVICE: Clearfil SE Bond|DEVICE: Tetric N-Bond
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pain Treatment With Combinations of NSAIDs
Status: COMPLETED
Conditions: Postoperative Pain, Acute
Interventions: DRUG: Aspirin|DRUG: Ketorolac|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on the Effect of Zhenyuan Capsule on Cardiopulmonary Function in Patients With SCAD
Status: UNKNOWN
Conditions: Stable Coronary Heart Disease
Interventions: DRUG: Zhenyuan capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: My Mobile Wallet: An Intervention for Tuberculosis Medication Adherence in Rural Uganda
Status: RECRUITING
Conditions: Tuberculosis
Interventions: OTHER: SMS texts + incentives + Wisepill device for medication monitoring|OTHER: SMS texts only + Wisepill device for medication monitoring|OTHER: Wisepill device for medication monitoring only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ultrasound Guided Transversus Abdominis Plane Block in Pediatric Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Bupivacaine 0.125%|DRUG: Bupivacaine 0.25%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Role of Postoperative Immobilization After Arthroscopic Rotator Cuff Repair
Status: COMPLETED
Conditions: Rotator Cuff Rupture
Interventions: DEVICE: Simple sling.|DEVICE: Neutral brace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanical Insufflation in the Philadelphia Amyotrophic Lateral Sclerosis Cohort (MI-PALS) Study
Status: NOT_YET_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis|Chronic Respiratory Failure|Airway Clearance Impairment|Neuromuscular Diseases
Interventions: DEVICE: Mechanical insufflation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cutaneous Manifestations of Coronavirus Disease 2019(COVID-19).
Status: COMPLETED
Conditions: Cutaneous Manifestations|Skin Manifestations|COVID-19|COVID-19 Pneumonia|COVID-19 Pandemic|Corona Virus Infection|Coronavirus Disease 2019|Sars-CoV-2 Infection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Electrical Optimization of Cardiac Resynchronization Therapy in Non-responder Patients
Status: TERMINATED
Conditions: Heart Failure|Cardiac Resynchronization Therapy
Interventions: DEVICE: Device programming of CRT pacemaker or defibrillator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile App-delivered Sleep Therapy (SleepFix) for Individuals With Chronic Low Back Pain and Insomnia
Status: RECRUITING
Conditions: Chronic Low-back Pain|Insomnia
Interventions: BEHAVIORAL: sleep retraining therapy|OTHER: sleep health education modules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Application of Transbronchial Cryobiopsy in the Diagnosis of Progressive Pulmonary Fibrosis
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Fibrosis|Transbronchial Cryobiopsy
Interventions: PROCEDURE: Transbronchial Cryobiopsy，TBLC|PROCEDURE: Transbronchial Lung Biopsy，TBLB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Beneficial Effect of Quadratus Lumborum Block After Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Cholecystectomy|Quadratus Lumborum Block
Interventions: PROCEDURE: Cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Intraoperative Esketamine on Postoperative Pain and Mood in Patients With Inflammatory Bowel Disease
Status: COMPLETED
Conditions: Crohn Disease|Depression|Esketamine
Interventions: DRUG: Esketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety Study of Tipranavir Co-administered With Low-dose Ritonavir (TPV/r) in Patients With Advanced HIV-1 Infection and Limited Treatment Options
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Tipranavir/Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Hepalatide(L47) at Phase Ib in Healthy Volunteers
Status: COMPLETED
Conditions: Hepatitis B， Chronic
Interventions: DRUG: Hepalatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Of Lapatinib In Combination With Paclitaxel In The Treatment Of Newly Diagnosed Inflammatory Breast Cancer
Status: COMPLETED
Conditions: Neoplasms, Breast
Interventions: DRUG: Lapatinib|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-myofascial Release With Foam Roller in Patients With Hemophilic Ankle Arthropathy
Status: COMPLETED
Conditions: Hemophilia
Interventions: OTHER: Self-Myofascial release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT
Status: NOT_YET_RECRUITING
Conditions: Monkeypox
Interventions: DRUG: Bavarian Nordic smallpox vaccine|DRUG: Typhoid VI Polysaccharide Vaccine Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Short and Intermediate Term Effect of Dapagliflozin on Left Ventricular Remodeling in Anterior STEMI Patients
Status: RECRUITING
Conditions: STEMI
Interventions: DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Therapy in Patients With Systemic Lupus Erythematosus (SLE)
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Cholecalciferol|DRUG: Cholecalciferol|DRUG: Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of Intravitreal Autologous CD34+ Stem Cell Therapy for Retinitis Pigmentosa
Status: COMPLETED
Conditions: Retinitis Pigmentosa
Interventions: BIOLOGICAL: Intravitreal autologous CD34+ cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (TENAYA)
Status: COMPLETED
Conditions: Wet Macular Degeneration
Interventions: DRUG: Faricimab|DRUG: Aflibercept|PROCEDURE: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sunitinib in Treating Patients With Metastatic Pancreatic Cancer That Progressed After First-Line Therapy With Gemcitabine
Status: COMPLETED
Conditions: Acinar Cell Adenocarcinoma of the Pancreas|Duct Cell Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer
Interventions: DRUG: sunitinib malate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cabergoline Versus Calcium Gluconate Infusion in the Prevention of Ovarian Hyperstimulation Syndrome
Status: COMPLETED
Conditions: OHSS
Interventions: DRUG: Cabergoline|DRUG: Calcium gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Digestion of Protein Powders in Healthy Participants Using SIMBA and LIMBA Capsule
Status: NOT_YET_RECRUITING
Conditions: Amino Acid Change|Food Science|Nutrition|Digestion Rate|Microtia
Interventions: DIETARY_SUPPLEMENT: Milk Protein Concentrate|DIETARY_SUPPLEMENT: Micellar Casein Isolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Metformin in Preventing Patients With Risperidone From Weight Gain and Amenorrhea
Status: WITHDRAWN
Conditions: Weight Gain|Amenorrhea
Interventions: DRUG: Metformin|OTHER: Starch tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Zoledronate, Calcium, and Vitamin D in Preventing Bone Loss in Women Receiving Adjuvant Chemotherapy for Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Osteoporosis
Interventions: DIETARY_SUPPLEMENT: calcium salts|DIETARY_SUPPLEMENT: cholecalciferol|DRUG: zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Auditory Stimulation in Eating Pleasure (EDERE 2021)
Status: UNKNOWN
Conditions: Frailty|Malnutrition|Anorexia|Presbycusis|Edentulism Nos
Interventions: DEVICE: Compare the noise and pleasure of crunching between two hyperprotein nutritional supplements
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Determining Whether Multiple Anesthesia Exposures Affect Cognitive Function for Retinoblastoma Patients
Status: RECRUITING
Conditions: Pediatric Retinoblastoma|Retinoblastoma
Interventions: OTHER: Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V)|OTHER: California Verbal Learning Test, Children's Version|OTHER: Beery Developmental Test of Visual Motor Integration, 6th edition|OTHER: Grooved Pegboard Test|OTHER: Behavior Assessment System for Children/Parent Report
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetics of Fixed Dose Combination (FDC) Tablets of Linagliptin /Metformin
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: linagliptin/metformin(high dose)|DRUG: Linagliptin/metformin(low dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Contamination of Ligatures
Status: COMPLETED
Conditions: Orthodontics
Interventions: OTHER: Leone slide low friction elastomeric ligature|OTHER: RMO tough - o energy elastomeric ligature|OTHER: Dentsply sili tie elastomeric ligature|OTHER: AO twisted ended ligature wire
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neoadjuvant Androgen Deprivation Therapy Combined With Enzalutamide and Abiraterone Using Multiparametric MRI and 18FDCFPyL PET/CT in Newly Diagnosed Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Castrate Sensitive Prostate Cancer
Interventions: DRUG: goserelin|DRUG: Enzalutamide|DRUG: Abiraterone|DRUG: 18F-DCFPyL|DRUG: Prednisone|PROCEDURE: Radical Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Personalized vs Standardized PN for Preterm Infants >1250g
Status: RECRUITING
Conditions: Infant,Premature|Parenteral Nutrition|Growth
Interventions: DRUG: Standardized-parenteral nutrition (S-PN)|DRUG: Personalized-parenteral nutrition (P-PN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ridaforolimus in Patients With Hepatic Insufficiency (MK-8669-046)
Status: COMPLETED
Conditions: Healthy Volunteers|Hepatic Insufficiency
Interventions: DRUG: ridaforolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of the Motivational Interviewing Technique on Breast and Cervical Cancer Screenings
Status: UNKNOWN
Conditions: Menopause|Cervix Cancer|Breast Cancer
Interventions: OTHER: Motivational Interviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Pediatric ALL Evaluation and Trial
Status: RECRUITING
Conditions: ACL Injury|ACL Tear
Interventions: PROCEDURE: Patients will be randomized into one of two study arms: (1) concomitant ACL and ALL reconstruction or (2) ACL reconstruction alone.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Wearable Technology to Reduce Sedentary Behavior and CVD Risk in Older Adults
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: BEHAVIORAL: Exercise|BEHAVIORAL: Non-Exercise Physical Activity (NEPA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Home Visiting Pilot Program on Early Childhood Outcomes in Fortaleza Brazil
Status: UNKNOWN
Conditions: Child Development
Interventions: BEHAVIORAL: Home visiting intervention PCCSF (220 clusters)|BEHAVIORAL: Home visiting without PCCSF (220 clusters)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase I and Pharmacokinetic Trial of Paclitaxel (Taxol) Given as a 3-Hour Infusion in Pediatric Patients With Refractory Malignancy
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Treated Blood Cells, Cyclophosphamide, Fludarabine Phosphate, and Aldesleukin in Treating Patients With Cancer
Status: TERMINATED
Conditions: Breast Cancer|Colorectal Cancer|Gastric Cancer|Lung Cancer|Ovarian Cancer|Pancreatic Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: MFE23 scFv-expressing autologous anti-CEA MFEz T lymphocytes|BIOLOGICAL: aldesleukin|DRUG: cyclophosphamide|DRUG: fludarabine phosphate|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oncolytic Virotherapy Combined With Tislelizumab Plus Lenvatinib in Patients With Advanced Biliary Tract Cancer (OPTIONS-05)
Status: RECRUITING
Conditions: Advanced Biliary Tract Cancer
Interventions: DRUG: H101|DRUG: Tislelizumab|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Dendrogenin A / Oxysterols Balance Between Healthy Volunteers and Acute Myeloid Leukemia Patients
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: Blood sample|BIOLOGICAL: Bone marrow sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Visual Outcomes and Patient Satisfaction After Cataract Surgery and Implantation of ReSTOR and ReZoom IOLs
Status: COMPLETED
Conditions: Cataract Extraction
Interventions: DEVICE: Cataract surgery and IOL implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of CO2 for Endoscopy
Status: COMPLETED
Conditions: Endoscopy|Insufflation
Interventions: DRUG: Carbon dioxide (CO2) gas insufflation|DRUG: Air insufflation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Neoadjuvant Chemotherapy With PISOXO for Locally-invaded-gastric Cancer (LIGC)
Status: UNKNOWN
Conditions: Stomach Cancer|Gastric Cancer
Interventions: DRUG: PIPAC+SOX+OLAPARIB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT