pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparison of Deep Versus Awake Tracheal Extubation in Adults
Status: COMPLETED
Conditions: Airway Complication of Anesthesia|Respiratory Complications of Care
Interventions: PROCEDURE: Extubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Serum Concentrations of a Human Monoclonal Antibody, VRC-HIVMAB075-00-AB (VRC07-523LS), Administered in Multiple Doses and Routes to Healthy, HIV-uninfected Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: VRC07-523LS|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ilaris® Effects in Schnitzler Syndrome (ILESCH)
Status: COMPLETED
Conditions: Schnitzler Syndrome
Interventions: DRUG: Canakinumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interscalene Versus Combined Infraclavicular-suprascapular Nerve Blocks
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: ICSSB group|PROCEDURE: ISB group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Diastasis Recti Abdominis and a Combined Treatment With Abdominal Exercise and Radiofrequency
Status: NOT_YET_RECRUITING
Conditions: Diastasis|Diastasis Recti|Diastasis Recti and Weakness of the Linea Alba|Diastasis Recti Abdominis
Interventions: OTHER: Radiofrequency|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Different Concentrations of Bupivacaine in Erector Spinae Plane Block in Hip Surgeries
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: PROCEDURE: Erector spinae plane block Technique|PROCEDURE: General anesthesia|DRUG: Bupivacaine 0.5%|DRUG: Bupivacaine 0.375%|DRUG: Bupivacaine 0.25%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tele-rehabilitation Intervention for People Post Hip Fracture - Randomized Controlled Trial (RCT)
Status: UNKNOWN
Conditions: Hip Fractures
Interventions: BEHAVIORAL: CO - OP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Islet Transplantation in Patients With "Brittle" Type I Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1
Interventions: BIOLOGICAL: Allogenic islet cells (human, U. Chicago)|PROCEDURE: Intraportal infusion of islet cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Antiglaucoma Agents on Short Term Intraocular Pressure Fluctuations After Intravitreal Bevacizumab Injection
Status: COMPLETED
Conditions: Intraocular Pressure Change in Intravitreal Injection
Interventions: DRUG: Timolol|DRUG: Brimonidine|DRUG: Acetazolamide|DRUG: Mannitol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Clinical Effect of Hip Protection Orthosis for the Hip Protection of Hip Dislocation in Patients With Severe Neuromuscular Disease, Pilot Study
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: DEVICE: Hip protection orthosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety of CERE-120 (AAV2-NTN) in Subjects With Idiopathic Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: GENETIC: CERE-120: AAV2-NTN
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cooling in Myocardial Infarction
Status: COMPLETED
Conditions: ST-elevation Myocardial Infarction
Interventions: DEVICE: EMCOOLS flex pad; Philips Innercool RTx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ranibizumab Versus Bevacizumab on the Macular Perfusion in Diabetic Macular Edema
Status: TERMINATED
Conditions: Diabetic Macular Edema|Macular Ischemia|Diabetic Retinopathy|Vascular Endothelial Growth Factor Overexpression
Interventions: DRUG: Intravitreal ranibizumab|DRUG: Intravitreal bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Range Finding Study to Evaluate the Effect of Bexagliflozin Tablets in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Bexagliflozin tablets|DRUG: Bexagliflozin tablets, placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Sodium Bicarbonate Solution in Decreasing the Incidence of Contrast Induced Nephropathy (CIN)
Status: COMPLETED
Conditions: Contrast Induced Nephropathy
Interventions: DRUG: Sodium Bicarbonate plus normal saline 0.9%|DRUG: normal saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hybrid Cardiac Rehabilitation Trial
Status: COMPLETED
Conditions: Coronary Artery Disease|Acute Coronary Syndrome
Interventions: OTHER: Comprehensive assessment|OTHER: Counseling|OTHER: Group education|OTHER: Exercise sessions in hybrid program|OTHER: Exercise sessions in standard program|OTHER: Transition to unsupervised phase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CVN058 Effect on Mismatch Negativity in Schizophrenics
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: CVN058|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PRedictiOn Algorithms for the DeTECTion of Early Stage Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer|Pancreatic Ductal Adenocarcinoma (PDAC)
Interventions: DIAGNOSTIC_TEST: Magnetic resonance imaging (MRI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study in Healthy Participants Investigating Biomarkers After Exposure to Heparin When Heparin is Administered in the Fasted State or After a High-fat Meal. Heparin, a Registered Drug, is an Anticoagulant (Blood Thinner) That Prevents the Formation of Blood Clots.
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Vemurafenib and Cobimetinib for the Treatment of Patients With High Risk Differentiated Thyroid Carcinoma With BRAFV600E Mutation
Status: RECRUITING
Conditions: Thyroid Gland Follicular Carcinoma|Thyroid Gland Oncocytic Carcinoma|Thyroid Gland Papillary Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Cobimetinib|PROCEDURE: Computed Tomography|PROCEDURE: Diagnostic Imaging|PROCEDURE: I-131 Uptake Test|RADIATION: Iodine I-131|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|BIOLOGICAL: Recombinant Thyrotropin Alfa|PROCEDURE: Ultrasound Imaging|DRUG: Vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of K-877 in Adult Patients With Fasting High Triglyceride Levels and Mild or Moderate Renal Impairment
Status: COMPLETED
Conditions: Severe Hypertriglyceridemia
Interventions: DRUG: K-877|DRUG: Fenofibrate|DRUG: Placebo (for K-877)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Study of Two Splints Used for Treatment of Acute Temporomandibular Pain.
Status: TERMINATED
Conditions: Myofascial Pain
Interventions: DEVICE: Aqualizer|DEVICE: Soft splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of a National Screening Programme for Bowel Cancer in Norway
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer|Colorectal Adenomas
Interventions: PROCEDURE: Flexible sigmoidoscopy|PROCEDURE: iFOBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Naltrexone Maintenance Treatment of Alcoholism
Status: COMPLETED
Conditions: Alcoholism
Interventions: DRUG: Naltrexone Tablet|DRUG: Matched Placebo Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rapid PCR to Guide Antibiotic Therapy at the Time of Prostate Biopsy
Status: COMPLETED
Conditions: Antibiotic Therapy|Prostate Biopsy
Interventions: OTHER: rPCR results|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Ritonavir-Boosted Invirase (Saquinavir) in Treatment-Naïve HIV-1 Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Nucleoside Reverse Transcriptase Inhibitor (NRTIs)|DRUG: ritonavir|DRUG: saquinavir [Invirase]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pictorial Support in Person-centred Care for Children (PicPecc)
Status: RECRUITING
Conditions: Childhood Cancer|Communication|Symptoms and Signs
Interventions: DEVICE: Pictorial support in person-centred care for children (PicPecc)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Protein Supplementation in Pilates Training
Status: COMPLETED
Conditions: Exercise Training|Dietary Supplements
Interventions: DIETARY_SUPPLEMENT: Whey protein|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Lingual Frenulum in Newborn Infants (LINNE)
Status: RECRUITING
Conditions: Tongue Tie|Frenulum Breve|Frenulum; Elongation|Breast Feeding
Interventions: PROCEDURE: Frenotomy|PROCEDURE: Oral physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Is Microbiota Community Associated With Clinical Response to a Low FODMAP Diet in Patients With Irritable Bowel Syndrome
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: low FODMAPs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Study of Manapol and DaltonMax on Immune Function, Microbiome, and Related Variables in Men and Women
Status: COMPLETED
Conditions: Microbiome|Immune Function
Interventions: DIETARY_SUPPLEMENT: Aloe Vera Extract 1|DIETARY_SUPPLEMENT: Control|DIETARY_SUPPLEMENT: Aloe Vera Extract 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Effectiveness of an Aldehyde Inhibitor Dehydrogenases (DIMATE) on the Cell Population Leukemic or Normal Stem
Status: UNKNOWN
Conditions: Leukemia
Interventions: BIOLOGICAL: blood sample|BIOLOGICAL: Stem cell donation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Evaluating the Effects of GLPG3667 Given as Oral Treatment for up to 24 Weeks in Adults With Dermatomyositis
Status: RECRUITING
Conditions: Dermatomyositis
Interventions: DRUG: GLPG3667|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of an Education and Guidance Programme for Eliquis Adherence in Non-Valvular Atrial Fibrillation (AEGEAN)
Status: COMPLETED
Conditions: Non-valvular Atrial Fibrillation
Interventions: DRUG: Apixaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of NM-702 Tablets for the Treatment of Intermittent Claudication
Status: COMPLETED
Conditions: Intermittent Claudication|Peripheral Vascular Disease
Interventions: DRUG: NM-702 (phosphodiesterase inhibitor)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Pharmacokinetics of Tafluprost Ophthalmic Solution (0.0015%) in Pediatric Patients With Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: Preservative free tafluprost opthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Study to Evaluate Ciprofloxacin/Celecoxib Combination in Patients With ALS
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis|ALS
Interventions: DRUG: Fixed dose combination Ciprofloxacin/Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accuracy of Continuous Glucose Monitoring in Patients With Diabetes. A Prospective Observational Study
Status: RECRUITING
Conditions: Diabetes Mellitus|Dysglycemia|Perioperative Complication|Circulatory; Complications
Interventions: DEVICE: Dexcom G7 Continuous Glucose Monitoring (CGM) System (G7)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mindfulness-Based Intervention for Emotional and Behavioural Problems of Students With Visual Impairment
Status: RECRUITING
Conditions: Emotional Problem|Behavior Problem
Interventions: BEHAVIORAL: Mindfulness-Based Stress Reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Importance of Restoring Biomechanical Correct Hip Anatomy During Total Hip Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: PROCEDURE: GF hip guide|PROCEDURE: Stryker Navigation System|DEVICE: ABG II modular femoral component
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Tumor Necrosis Factor Receptor Fusion Protein Etanercept (Enbrel) in Psoriasis of the Hands and/or Feet
Status: COMPLETED
Conditions: Psoriasis
Interventions: BIOLOGICAL: Etanercept|OTHER: Placebo injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Antihypertensive Efficacy of MK0954
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: losartan potassium|DRUG: Comparator: losartan|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of APR-246 in Combination With Dabrafenib in Resistant Patients With BRAF V600 Mutant Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: APR-246|DRUG: Dabrafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: R230C and C230C Variants of ABCA1 and Glyburide Response
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Glyburide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of a Powered Exoskeleton Combined With FES for Patients With Chronic SCI: a RCT
Status: RECRUITING
Conditions: Spinal Cord Injuries|Gait Disorders, Neurologic
Interventions: DEVICE: Ekso (EksoNR, Ekso Bionics)|DEVICE: FES (RehaMove2, Hasomed)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioactive Smart Dressings for Diabetic Foot Ulcers: Randomized Controlled Trial
Status: COMPLETED
Conditions: Diabetic Foot Ulcer
Interventions: COMBINATION_PRODUCT: PRP gel and SOC-treatment|COMBINATION_PRODUCT: EPO/ISDN/UFH cryogel dressing|PROCEDURE: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Oral Zanthoxylum Schinifolium Seed Oil in Individuals With Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DIETARY_SUPPLEMENT: Zanthoxylum Schinifolium Seed Oil(4g/day)|DIETARY_SUPPLEMENT: Soy Bean Oil;placebo(4g/day)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of a New Orange-Based Beverage Enriched With Polyphenols in Adult Humans
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: OTHER: Orange juice based beverage enriched in polyphenols
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intraoral Appliance in the Treatment of Obstructive Sleep Apnea Syndrome in Obese
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea|Obesity
Interventions: DEVICE: mandibular advancement device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: THE EFFECT OF HELICOBACTER PYLORI ERADICATION THERAPY TO GASTRIC WALL THICKNESS BEFORE THE LAPAROSCOPIC SLEEVE GASTRECTOMY
Status: COMPLETED
Conditions: Helicobacter Pylori Infection|Obesity, Morbid
Interventions: DRUG: Bismuth Subsalicylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PG2 Treatment for Improving Fatigue Among Advanced Cancer Patients Under Standard Palliative Care
Status: COMPLETED
Conditions: Cancer-related Fatigue
Interventions: DRUG: Astragalus Polysaccharides 500 mg|DRUG: Astragalus Polysaccharides 250 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Atezolizumab and Derazantinib in Patients With Advanced iCCA With FGFR2 Fusions/Rearrangements
Status: ACTIVE_NOT_RECRUITING
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: DRUG: Atezolizumab|DRUG: Derazantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Efficacy and Safety of Fluticasone Furoate in the Treatment of Asthma in Adults and Adolescents
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: fluticasone furoate|DRUG: albuterol/salbutamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Non-medical Health Worker (NMHW) Led Counseling on Common Mental Disorders in Rural Mid-western Nepal
Status: COMPLETED
Conditions: Mental Disorders|Psychological Distress|Depression|Anxiety|Coping
Interventions: BEHAVIORAL: Psychosocial counselling|OTHER: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Living Kidney Donor Lost Wages Trial
Status: COMPLETED
Conditions: Kidney Diseases
Interventions: OTHER: Standard of Care|BEHAVIORAL: Wage Reimbursement A|BEHAVIORAL: Wage Reimbursement B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Alfred Step Test Exercise Protocol (A-STEP), for Adults With Cystic Fibrosis.
Status: RECRUITING
Conditions: Cystic Fibrosis|Fibrosis|Lung Diseases|Respiratory Diseases|Genetic Diseases|Pancreatic Diseases
Interventions: OTHER: A-STEP|OTHER: A-STEP (New Protocol)|OTHER: Comparator: CPET cycle ergometer (Gold Standard)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess the Drug-Drug Interaction Between Bedaquiline and Clarithromycin in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Bedaquiline|DRUG: Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluating Tetrahydrocannabinol as an Adjunct to Opioid Agonist Therapy
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder|Methadone|Cannabis|Fentanyl
Interventions: DRUG: Aurora 1:1 Drops (Indica)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoepitope-based Personalized Vaccine Approach in Patients With Newly Diagnosed Glioblastoma
Status: TERMINATED
Conditions: Glioblastoma Multiforme|Astrocytoma, Grade IV
Interventions: BIOLOGICAL: Personalized peptide vaccine|DRUG: Poly-ICLC|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study on the Improvement of Skin and Living Conditions After Drinking Rosa Roxburghii and Pomegranate Drinks
Status: COMPLETED
Conditions: Skin Laxity
Interventions: COMBINATION_PRODUCT: skin care product|OTHER: Drinks with active ingredients Rosa Roxburghii and Pomegranate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: An Effectiveness and Safety 6 Months Study of 3 Injections One Week Apart of SYNOLIS VA 40/80 in the Treatment of Symptomatic Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteo Arthritis Knee
Interventions: DEVICE: SYNOLIS VA 40/80
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Child-Adult Relationship Enhancement in Primary Care (PriCARE) / Criando Niños Con CARIÑO (CARIÑO)
Status: RECRUITING
Conditions: Parent-Child Relations|Child Maltreatment
Interventions: BEHAVIORAL: PriCARE/CARIÑO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Effectiveness of Two Methods of Regional Anesthesia During S-ICD Implantation Procedure.
Status: RECRUITING
Conditions: Chest Pain|Pain, Procedural|Pain, Postoperative|Analgesia|Regional Anesthesia Morbidity|Anesthesia, Local|ICD
Interventions: PROCEDURE: Regional anaesthetic combined fascial plane block|DRUG: Ropivacaine 0.125% Injectable Solution +Lignocaine 0,25% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: Evaluation of Tolerance and Trichological Efficacy of a Food Supplement
Status: COMPLETED
Conditions: Telogen Effluvium
Interventions: DIETARY_SUPPLEMENT: Bioscalin® new formulation with Galeopsis Segetum|DIETARY_SUPPLEMENT: Reference product|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: S0414 Cetuximab, Combo Chemo, and RT in Locally Advanced Esophageal Cancer
Status: TERMINATED
Conditions: Esophageal Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: cisplatin|DRUG: irinotecan hydrochloride|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of Peripheral Immune Cell Activity During Treatment With Either Surgery or Radiotherapy in Patients With Early Stage NSCLC
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: PROCEDURE: Surgery|RADIATION: SABR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: T-PRF Provides Advantages on Periodontal Healing: A Split Mouth Clinical Study
Status: COMPLETED
Conditions: Periodontitis|Periodontal Attachment Loss
Interventions: PROCEDURE: T-PRF|PROCEDURE: Open Flap Debridement alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of IN.PACT Admiral® Drug Coated Balloon vs Standard PTA for the Treatment of SFA and Proximal Popliteal Arterial Disease
Status: COMPLETED
Conditions: Peripheral Arterial Disease (PAD)
Interventions: DEVICE: Drug-Coated Balloon (DCB)|DEVICE: PTA Balloon: Balloon Angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Assessing the Safety and Efficacy of ABT-263 in Subjects With B-cell Chronic Lymphocytic Leukemia (CLL) Who Have Failed at Least One Prior Fludarabine-containing Regimen
Status: WITHDRAWN
Conditions: B-cell Chronic Lymphocytic Leukemia
Interventions: DRUG: ABT-263
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SPY Fluorescence Imaging Systems and Indocyanine Green to Determine the Percentage of Successful Critical Anatomy Recognition in Laparoscopic Cholecystectomy Surgeries.
Status: TERMINATED
Conditions: Cholecystitis
Interventions: DEVICE: Stryker1688 Fluorescence imaging system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: COVidIVERmectin: Ivermectin for Treatment of Covid-19
Status: TERMINATED
Conditions: Covid19
Interventions: DRUG: Ivermectin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Move With Air: Physiological Response Assessment
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease|Interstitial Lung Disease|Heart Failure
Interventions: DEVICE: Honeywell HT-900 Turbo Force Air Circulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-Guided Popliteal Plexus Block Versus Fascia Iliaca Block After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Total Knee Arthroplasty|Popliteal Plexus Block|Fascia Iliaca Block
Interventions: DEVICE: Ultrasound-Guided Popliteal Plexus Block|DEVICE: Ultrasound-Guided Fascia Iliaca block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reliability and Versatility of Supraclavicular Artery Flap in Reconstruction of Head and Neck Soft Tissue Defects
Status: RECRUITING
Conditions: Reconstruction of Head Soft Tissue Defects|Reconstruction of Neck Soft Tissue Defects
Interventions: PROCEDURE: Reconstruction of Soft tissue defects of head and neck by Supraclavicular artery flap
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity (DH)
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: OTHER: Stannous fluoride|OTHER: Sodium monofluorophosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Real-World Endeavor Resolute Versus XIENCE V Drug-Eluting Stent Study in Twente
Status: COMPLETED
Conditions: Coronary Artery Disease|Angina Pectoris|Unstable Angina Pectoris|Coronary Stenosis|Coronary Restenosis
Interventions: DEVICE: Endeavor Resolute (Biolinx-based Zotarolimus-eluting stent)|DEVICE: Xience V (Everolimus-eluting stent)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Glucose 5% on Labor Length
Status: UNKNOWN
Conditions: Induction of Labor Affected Fetus / Newborn
Interventions: DRUG: Dextrose 5%/Nacl 0.3% Inj_#3|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Tislelizumab, Gemcitabine and Cisplatin for R/R Hodgkin Lymphoma Followed by Tislelizumab Consolidation in Patients in Metabolic Complete Remission
Status: RECRUITING
Conditions: Hodgkin Lymphoma
Interventions: DRUG: gemcitabine, cisplatin and tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics and Pharmacodynamics After Single and Multiple Dosing of AZD5423 in Japanese Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD5423|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy Study of Subcutaneous Methyl-B12 in Children With Autism
Status: COMPLETED
Conditions: Autistic Disorder
Interventions: DRUG: methylcobalamin|OTHER: saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of the Anemia of Myelodysplastic Syndromes by the Association of Epoetin Beta and All Trans Retinoic Acid
Status: UNKNOWN
Conditions: Anemia in Myelodysplastic Syndromes
Interventions: DRUG: Epoetin/Atra
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gut Microbiome in Orthopaedics
Status: NOT_YET_RECRUITING
Conditions: Total Knee Arthroplasty|Inflammation|Gastrointestinal Health
Interventions: DIETARY_SUPPLEMENT: Probiotic Formula Bacillus subtilis|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Anticoagulation for All-comers Undergoing Percutaneous Coronary Revascularization Trial
Status: TERMINATED
Conditions: Percutaneous Coronary Intervention
Interventions: DRUG: Bivalirudin|DRUG: Unfractionated heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: To Assess the Effect of Rifampicin on the Pharmacokinetics of Selumetinib in Healthy Male Volunteers
Status: COMPLETED
Conditions: Solid Tumours
Interventions: DRUG: selumetinib|DRUG: rifampicin|DRUG: selumetinib|DRUG: rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: TrEatment Targets in Rheumatoid Arthritis: TETRA-study
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: OTHER: Treatment target DAS28CRP-LDA|OTHER: Treatment target SDAI-remission
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dermacyd PH_DETINBACK (Lactic Acid) Sweet Flower - Safety.
Status: COMPLETED
Conditions: Hygiene
Interventions: DRUG: Dermacyd PH_DETINBACK (Lactic Acid) Sweet Flower
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tolerability of a Modified Health-Dx
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DEVICE: modified Health- Dx™ (mHDx) study capsule|DEVICE: modified Health- Dx™ (mHDx) control capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: "The Impact of Immunonutrition on Gut Microbiota-related Aspects in Colorectal Cancer and Gastric Cancer Patients"
Status: UNKNOWN
Conditions: Gastric Cancer|Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: Impact Oral Nestlé Health Science, Cubitan® Nutricia, Nutridrink® Nutricia, Resource 2.0 Nestlé Health Science
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Perinatal Depression & Anxiety (PDA) and Maternal Gut Microbiome
Status: RECRUITING
Conditions: Perinatal Depression|PerinatalAnxiety
Interventions: DIETARY_SUPPLEMENT: Fish oil|DIETARY_SUPPLEMENT: Probiotics|BEHAVIORAL: Prebiotics|BEHAVIORAL: Diet Quality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 2a Study to Evaluate Suppression of Methotrexate-induced Mucositis by TK112690
Status: COMPLETED
Conditions: Mucositis
Interventions: DRUG: TK-112690|DRUG: Placebo TK-112690
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Stress-MRI Assessment After Right Coronary Artery CTO Recanalization
Status: COMPLETED
Conditions: Ischemic Heart Disease|Coronary Atherosclerosis|Coronary Artery Disease|Coronary Artery Stenosis
Interventions: PROCEDURE: CTO coronary angioplasty|DRUG: Optimal medicamentous treatment|PROCEDURE: Stress-MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study Evaluating Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasm
Status: ACTIVE_NOT_RECRUITING
Conditions: Myeloproliferative Neoplasm
Interventions: DRUG: Navitoclax|DRUG: Ruxolitinib|DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zushima Plaster for Treating Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Zushima plaster with high dose|DRUG: Zushima plaster with low dose|DRUG: Indometacin Cataplasms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PipEracillin/Tazobactam Versus mERoPENem for Treatment of AmpC Producing Blood Stream Infections
Status: SUSPENDED
Conditions: Beta Lactam Resistant Bacterial Infection|Enterobacteriaceae Infections|Bacteremia
Interventions: DRUG: Piperacillin / Tazobactam Injection|DRUG: Meropenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Standard Laser With Micropulse Laser for the Treatment of Diabetic Macular Oedema.
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: PROCEDURE: Diode 577 nm subthreshold micropulse laser|PROCEDURE: Standard threshold laser (532 nm laser)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomised, Double- Blind, Placebo Controlled, Cross-over Efficacy and Safety Comparison of Tiotropium 5 µg Once Daily and Tiotropium 2.5 µg Twice Daily for Four Weeks in Patients With Moderate Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Tiotropium 2.5 µg b.i.d|DRUG: Placebo|DRUG: Tiotropium 5 µg q.d.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Exercise the Mind and Brain. A Multimodal Intervention in Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: BEHAVIORAL: Multicomponent Physical Activity Program|BEHAVIORAL: Mindfulness-Based Stress Reduction Program|BEHAVIORAL: Computerized Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Dapagliflozin on Renal Outcomes and Cardiovascular Mortality in Patients With Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation for Freezing of Gait
Status: COMPLETED
Conditions: Parkinsonian Disorders
Interventions: DEVICE: rTMS Motor cortex|DEVICE: rTMS Supplementary motor area
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine in the Treatment of Symptoms Of Acute Opioid Withdrawal
Status: COMPLETED
Conditions: Opioid Withdrawal
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sleep Ventilation for Patients With Advanced Hypercapnic COPD
Status: WITHDRAWN
Conditions: COPD
Interventions: DEVICE: Home noninvasive nocturnal ventilation with Breas VIVO 50 home ventilator or newer model as available, Breas Medical.|DIAGNOSTIC_TEST: Arterial blood gas (ABG) and serum bicarbonate level|DIAGNOSTIC_TEST: Overnight home oximetry and transcutaneous CO2 monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-Center Actual-Use Study on the Safety of CL 108 for the Treatment of Moderate to Severe Acute Pain Associated With Osteoarthritis of the Knee or Hip
Status: COMPLETED
Conditions: Pain|Nausea|Vomiting
Interventions: DRUG: CL-108
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety, Tolerability, and Immunogenicity of Heterologous Prime-boost Regimens Using the Multivalent Filovirus Vaccines Ad26.Filo and MVA-BN-Filo Administered in Different Sequences and Schedules in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Ad26.Filo|BIOLOGICAL: MVA-BN-Filo|BIOLOGICAL: Ad26.ZEBOV|BIOLOGICAL: Placebo|BIOLOGICAL: MVA-BN-Filo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Randomised Trial of a Moisturising Cream in Preventing Recurrence of Hand Eczema
Status: COMPLETED
Conditions: Hand Eczema
Interventions: DRUG: Urea|DRUG: betamethasone valerate|DRUG: betamethasone valerate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: NECTAR Study: Nectar (Honey) Effects on Comfort, Thoughts, and Regularity
Status: COMPLETED
Conditions: Gastrointestinal Dysfunction|Physiological Stress|Cognition - Other
Interventions: DIETARY_SUPPLEMENT: Yogurt with B. lactis and added honey|DIETARY_SUPPLEMENT: Yogurt with heat-inactivated B. lactis and added cane sugar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Analysis of a Tapered Porous Coated Stem and a Cementless Hemispherical Acetabular Component
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis, Hip
Interventions: DEVICE: Femoral Component:Medacta Masterloc Stem and Medacta MPACT cup.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vaccination for Recovered Inpatients With COVID-19 (VATICO)
Status: COMPLETED
Conditions: Covid19
Interventions: BIOLOGICAL: Moderna mRNA-1273 COVID-19 vaccine|BIOLOGICAL: Pfizer BNT162b2 COVID-19 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiotherapy in Overactive Bladder: Electrical Stimulation Treatment
Status: COMPLETED
Conditions: Overactive Bladder Syndrome
Interventions: DEVICE: TTNS|DEVICE: ES+TTNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Combination of AFM13 and Pembrolizumab in Patients With Relapsed or Refractory Classical Hodgkin Lymphoma
Status: COMPLETED
Conditions: Hodgkin Lymphoma
Interventions: BIOLOGICAL: AFM13|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib in Treating Patients With Refractory Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Sorafenib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Trial of APL 400-003 Vaccine: Safety and Immune Response Evaluations of Multiple Injections at Escalating Doses in Asymptomatic HIV-Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: APL 400-003
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative In-Vivo Wetting Characteristics of Silicone Hydrogel Materials With Selected Lens Care Systems
Status: COMPLETED
Conditions: Myopia|Astigmatism|Refractive Error
Interventions: DEVICE: Lotrafilcon B contact lenses|DEVICE: Senofilcon A contact lenses|DEVICE: OPTI-FREE® PUREMOIST® MPDS|DEVICE: BIOTRUE®|DEVICE: Balafilcon A contact lenses|DEVICE: ReNu® Multiplus®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Lifestyle Online Re-Intervention On Blood Pressure, BMI, And Physical Activity On Obese Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension|Overweight and Obesity
Interventions: BEHAVIORAL: Reintervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carbapenem-resistant Enterobacteriaceae: Prevalence, Risk Factors and Impact of the Use of the Phenotypic Algorithm for the Detection of Carbapenemases
Status: COMPLETED
Conditions: Enterobacteria Non Susceptible to Carbapenem Carrier|Enterobacteria Susceptible to Carbapenem Carrier
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Gluteal Turnover Flap for Closure of the Perineal Wound After Abdominoperineal Resection for Rectal Cancer
Status: UNKNOWN
Conditions: Wound Heal|Abdominoperineal Resection|Rectal Cancer
Interventions: PROCEDURE: Gluteal turnover flap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Seroquel (Quetiapine Fumarate) as Mono-Therapy for Acute Schizophrenic
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Quetiapine Fumarate (Seroquel)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Decisions for Multi-vessel CAD
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: BEHAVIORAL: The Multi-vessel Coronary Artery Disease Option Grid|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Opioid-sparing Effect of Intravenous Ibuprofen
Status: UNKNOWN
Conditions: Analgesia|Percutaneous Nephrolithotomy
Interventions: DRUG: Acetaminophen|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT