pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pharmacokinetic, Safety, and Tolerability Study of Intranasally Administered Esketamine in Healthy Han Chinese, Korean, Japanese, and Caucasian Participants and the Effects of Rifampin on the Pharmacokinetics of Intranasally Administered Esketamine
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Esketamine|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visual Restoration for Hemianopia
Status: COMPLETED
Conditions: Stroke Induced Vision Loss|Hemianopia|Quadrantanopia
Interventions: DEVICE: Training in the blind field|DEVICE: Training in the intact field
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia
Status: COMPLETED
Conditions: Accelerated Phase Chronic Myelogenous Leukemia|Acute Leukemias of Ambiguous Lineage|Acute Myeloid Leukemia/Transient Myeloproliferative Disorder|Acute Undifferentiated Leukemia|Aggressive NK-cell Leukemia|Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative|Blastic Phase Chronic Myelogenous Leukemia|Blastic Plasmacytoid Dendritic Cell Neoplasm|Childhood Burkitt Lymphoma|Childhood Chronic Myelogenous Leukemia|Childhood Diffuse Large Cell Lymphoma|Childhood Grade III Lymphomatoid Granulomatosis|Childhood Immunoblastic Large Cell Lymphoma|Childhood Nasal Type Extranodal NK/T-cell Lymphoma|Chronic Eosinophilic Leukemia|Chronic Myelomonocytic Leukemia|Chronic Neutrophilic Leukemia|Chronic Phase Chronic Myelogenous Leukemia|Intraocular Lymphoma|Juvenile Myelomonocytic Leukemia|Mast Cell Leukemia|Myeloid/NK-cell Acute Leukemia|Noncutaneous Extranodal Lymphoma|Post-transplant Lymphoproliferative Disorder|Primary Central Nervous System Hodgkin Lymphoma|Primary Central Nervous System Non-Hodgkin Lymphoma|Progressive Hairy Cell Leukemia, Initial Treatment|Prolymphocytic Leukemia|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Recurrent/Refractory Childhood Hodgkin Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Relapsing Chronic Myelogenous Leukemia|Secondary Acute Myeloid Leukemia|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Unspecified Childhood Solid Tumor, Protocol Specific|Waldenström Macroglobulinemia
Interventions: DRUG: Akt inhibitor MK2206|OTHER: diagnostic laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Herpes Simplex Virus Type 2 (HSV-2) Suppression to Prevent HIV Transmission
Status: COMPLETED
Conditions: HIV Infection|Herpes Simplex, Genital|Sexually Transmitted Diseases
Interventions: DRUG: Generic acyclovir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of SomatoKine (Iplex)Recombinant Human Insulin-like Growth Factor-1/Recombinant Human Insulin-like Growth Factor-binding Protein-3 (rhIGF-I/rhIGFBP-3) in Myotonic Dystrophy Type 1 (DM1)
Status: COMPLETED
Conditions: Myotonic Dystrophy
Interventions: DRUG: SomatoKine/IPLEX
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: iKanEat: A Randomized-controlled, Multi-center Trial of Megestrol for Chronic Oral Food Refusal in Children
Status: RECRUITING
Conditions: Feeding Behavior|Feeding Disorder of Infancy or Early Childhood
Interventions: DRUG: Megestrol Acetate|BEHAVIORAL: iKanEat Behavioral Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oral Semaglutide Versus Liraglutide and Versus Placebo in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: semaglutide|DRUG: liraglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: High Flow Oxygen in Preoxygenation During Rapid Sequence Induction in Infants and Small Children
Status: RECRUITING
Conditions: Rapid Sequence Induction (RSI)|Preoxygenation
Interventions: PROCEDURE: face-mask preoxygenation|PROCEDURE: HFNOC preoxygenation|PROCEDURE: HFNOC + face-mask preoxygenation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Single Ascending Dose Study of ACT-541468 in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: ACT-541468 (Formulation A)|DRUG: ACT-541468 (Formulation B)|DRUG: Placebo (Formulation A)|DRUG: Placebo (Formulation B)|DRUG: 14C-labeled ACT-541468|DRUG: Placebo tracer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: MTX-related Liver Toxicity in Psoriasis Patients, Using Ultrasound-based Techniques as a Diagnostic Tool
Status: UNKNOWN
Conditions: Psoriasis|Liver Fibrosis
Interventions: DRUG: Discontinue methotrexate|OTHER: Medication depends on clinical judgement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety of and Immune Response to a DNA HIV Vaccine Followed By Boosting With One of Two Serotypes of Adenoviral Vector HIV Vaccine in Healthy Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: VRC-HIVADV027-00-VP|BIOLOGICAL: VRC-HIVADV038-00-VP|BIOLOGICAL: VRC-HIVDNA044-00-VP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Lifestyle Modification for Type 2 Diabetes Prevention in Overweight Youth
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Obesity
Interventions: BEHAVIORAL: Lifestyle Modification for Type 2 Diabetes Prevention|OTHER: Nutrition and Physical Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Bosentan (Tracleer) in the Course of Pulmonary Artery Hypertension Induced by Hypoxia
Status: COMPLETED
Conditions: Hypoxia-Induced Pulmonary Artery Hypertension
Interventions: DRUG: Bosentan|DRUG: Bosentam TRACLEER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Fenofibrate on Metabolic and Reproductive Parameters in Polycystic Ovary Syndrome
Status: TERMINATED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Fenofibrate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Infusion of Donor Derived Cytokine Induced Killer (CIK) Cells in Hematological Patients Relapsed After Haploidentical Stem Cell Transplant
Status: UNKNOWN
Conditions: Relapsed Hematologic Malignancy
Interventions: BIOLOGICAL: donor-derived CIK cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Pharmacokinetic Drug Interactions Between HGP1201 and HGP0904
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HGP1201|DRUG: HGP0904|DRUG: HGP0904 and HGP1201 co-administraion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Efficacy of Consolidative Hypofractionated Radiation Therapy for Boosting Residual Lung Cancer With Durvalumab
Status: RECRUITING
Conditions: Lung Cancer|Carcinoma, Non-Small Cell Lung
Interventions: RADIATION: consolidative hypofractionated radiation therapy (hfRT)|DRUG: Durvalumab 50 MG/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Intervention on Cognitive Impairment of Schizophrenia With Metabolic Syndrome
Status: SUSPENDED
Conditions: Schizophrenia
Interventions: DRUG: Omega-3 polyunsaturated fatty acids|BEHAVIORAL: Xbox aerobic exercise|DEVICE: transcranial direct current stimulation,tDCS|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Term Effects of Ivacaftor in Non-G551D Cystic Fibrosis Patients
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: ivacaftor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: REmotely Supervised Exercise Therapy Trial 2
Status: RECRUITING
Conditions: Claudication, Intermittent|Peripheral Arterial Disease
Interventions: BEHAVIORAL: Remotely supervised exercise programme|BEHAVIORAL: Self-directed exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-operative Intravenous Iron to Treat Iron-deficiency Anemia in Patients Undergoing Cardiac Surgery
Status: NOT_YET_RECRUITING
Conditions: Chronic Iron Deficiency Anaemia|Cardiac Surgery
Interventions: DRUG: Monoferric Injectable Product|OTHER: 0.9% sodium chloride solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Remifentanil on Respiratory Function in Mechanically Ventilated Patients
Status: COMPLETED
Conditions: Respiratory Insufficiency|Respiration, Artificial|Conscious Sedation
Interventions: DRUG: remifentanil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Attachment Based Family Therapy for Suicidal Adolescents
Status: COMPLETED
Conditions: Suicide|Depression|Family Relationships
Interventions: BEHAVIORAL: Attachment-Based Family Therapy|BEHAVIORAL: Family-Enhanced Non-directive Supportive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: reGional Network for Acute Myocardial Infarction
Status: UNKNOWN
Conditions: Coronary Heart Disease|Acute Myocardial Infarction|STEMI - ST Elevation Myocardial Infarction
Interventions: BEHAVIORAL: public education and network construction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Endoluminal Radiofrequency Ablation for the Treatment of Malignant Biliary Stenosis
Status: COMPLETED
Conditions: Radiofrequency Ablation|Biliary Tract Cancer|Stent Complication|Brachytherapy
Interventions: DEVICE: Habib™ EndoHPB; Boston Scientific, US; former EMcision Ltd., UK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Renal Failure by Nitric Oxide in Prolonged Cardiopulmonary Bypass.
Status: COMPLETED
Conditions: Heart Valve Diseases|Heart; Complications, Valve, Prosthesis|Cardiac Valve Replacement Complication
Interventions: OTHER: inhaled nitric oxide|OTHER: inhaled Nitrogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Metformin Treatment of Pregnant Women With Polycystic Ovary Syndrome: a Pilot Study
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A RCT of Triple Therapy With Proton Pump Inhibitor vs Vonoprazan for Helicobacter Pylori Gastritis
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Omeprazole 20mg|DRUG: Esomeprazole 20mg|DRUG: Rabeprazole Sodium 20mg|DRUG: Vonoprazan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Efficacy of RUTI® to Reduce the Severity of SARS-CoV-2 Infection (COVID-19)
Status: WITHDRAWN
Conditions: COVID-19
Interventions: BIOLOGICAL: RUTI® vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Spinal Dexamethasone During Transuretheral Prostatectomy
Status: COMPLETED
Conditions: Postspinal Shivering
Interventions: DRUG: Dexamethasone|DRUG: Pethidine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of On-Site Versus Off-Site Evaluation of Cholangioscopy-Guided Biopsies of the Bile Duct
Status: COMPLETED
Conditions: Bile Duct Stricture
Interventions: OTHER: on-site specimen evaluation|OTHER: off-site specimen evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Macrovascular and Microvascular Morbidity and Mortality After Metabolic Surgery Versus Medicines
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Obesity|Microvascular Disease|Macrovascular Disease|Major Adverse Cardiovascular Events|Nephropathy|Retinopathy|Heart Failure|All Cause Mortality
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Esomeprazole or Pantoprazole in Renal Transplantation
Status: COMPLETED
Conditions: Kidney Transplant; Complications
Interventions: DRUG: Esomeprazole 40 mg|DRUG: Pantoprazole 40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Relative Bioavailability of STI-1558 and the Effect of Itraconazole and Rifampin on the Pharmacokinetics of STI-1558
Status: COMPLETED
Conditions: COVID-19 Pneumonia
Interventions: DRUG: STI-1558|DRUG: Itraconazole|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Reference Values for Videofluoroscopic Measures of Swallowing
Status: ENROLLING_BY_INVITATION
Conditions: Dysphagia, Oropharyngeal
Interventions: DIAGNOSTIC_TEST: Videofluoroscopic Swallowing Study (VF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Knack on Female Stress Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence, Stress
Interventions: OTHER: the Knack|OTHER: PFMT|OTHER: The Knack + PFMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rituximab to Treat Moderate Aplastic Anemia, Pure Red Cell Aplasia, or Diamond Blackfan Anemia
Status: COMPLETED
Conditions: Anemia, Aplastic|Red-Cell Aplasia, Pure|Anemia, Diamond-Blackfan
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Physical Activity Improvement With the Use of Activity Trackers Before Radical Cystectomy (PreAct)
Status: RECRUITING
Conditions: Bladder Cancer|Bladder Neoplasm|Bladder Urothelial Carcinoma
Interventions: DEVICE: Daily Activity Goal and Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CPI-613 in Combination With Modified FOLFIRINOX in Locally Advanced Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: CPI 613|DRUG: Oxaliplatin|DRUG: Irinotecan|DRUG: 5-flurouracil|DRUG: Folinic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carrageenan-Containing Gel in Reducing the Rate of HPV Infection in Healthy Participants
Status: WITHDRAWN
Conditions: Healthy Subject|Human Papillomavirus Infection
Interventions: DRUG: carrageenan-containing gel|OTHER: Placebo|OTHER: Laboratory Biomarker Analysis|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Determination of Circulating Autotaxin in Patients With GNAS or PTH Abnormalities
Status: COMPLETED
Conditions: Fibrous Dysplasia|Albright Syndrome|Adult Children|Hypoparathyroidism|Hyperparathyroidism|Pseudo Hypoparathyroidism
Interventions: BIOLOGICAL: blood sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Liraglutide Effectiveness in Preoperative Weight-loss for Bariatric-metabolic Surgery
Status: COMPLETED
Conditions: Weight Loss|Bariatric Surgery Candidate|Obesity, Morbid
Interventions: DRUG: Liraglutide injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Combination of Anecortave Acetate and Triamcinolone Acetonide for the Treatment of Exudative Age-Related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Maculopathy, Age-Related
Interventions: DRUG: Anecortave Acetate 15 mg|DRUG: Triamcinolone Acetate 4 mg|PROCEDURE: Photodynamic Therapy with Verteporfin|PROCEDURE: Thermal Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CTNAV II : Multicentric Evaluation of IMACTIS-CT Navigation System
Status: COMPLETED
Conditions: Drainage|Biopsy|Punction|Ablation
Interventions: DEVICE: Navigation station (IMACTIS-CT®)|DEVICE: CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dermogenesis With Mesenchymal Stem Cells
Status: COMPLETED
Conditions: Dermal Regeneration
Interventions: PROCEDURE: Autologous Mesenchymal stem cells injection|PROCEDURE: Homogenized fat injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of TR 987, Beta-1,3-1,6-D-glucan, in the Treatment of Chronic Venous Insufficiency Ulcers
Status: ACTIVE_NOT_RECRUITING
Conditions: Venous Leg Ulcer
Interventions: DRUG: 0.1% TR 987|DRUG: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reduction in the Occurrence of Center-Involved Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Retinopathy
Interventions: DRUG: ruboxistaurin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eyes On Lips? Speechreading Skills and Facial Expression Discrimination in Children With and Without Impaired Hearing
Status: RECRUITING
Conditions: Hearing Impairment|Hearing Impaired Children
Interventions: BEHAVIORAL: Speechreading training with an application
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pelvic Floor Muscles Training After Radical Prostatectomy.
Status: UNKNOWN
Conditions: Pelvic Floor Disorders|Urinary Incontinence|Prostatectomy
Interventions: OTHER: Pre- and post prostatectomy supervised PMFT|OTHER: Unsupervised PMFT|OTHER: Supervised PMFT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Accelerated Intermittent Theta-Burst Stimulation for Opiate Use Disorder
Status: WITHDRAWN
Conditions: Opiate Dependence|Suicidal Ideation|Depression|Opioid Use|Opioid-Related Disorders|Opioid-use Disorder|Major Depressive Disorder
Interventions: DEVICE: Accelerated intermittent theta-burst stimulation (aiTBS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Meropenem Dosage Strategy Based on PPK Model
Status: COMPLETED
Conditions: Lower Respiratory Tract Infection
Interventions: DRUG: Routine meropenem therapy|DRUG: Meropenem therapy based on a PPK and PD model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Desvenlafaxine Succinate Sustained-Release (DVS SR) In The Treatment Of Child And Adolescent Outpatients With Major Depressive Disorder
Status: COMPLETED
Conditions: Depression|Major Depressive Disorder
Interventions: DRUG: Desvenlafaxine Succinate Sustained-Release Tablets (DVS SR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Evaluating Glial Acetate Metabolism as a Biomarker of Hypoglycemic Counterregulation
Status: RECRUITING
Conditions: Diabetes|Hypoglycemia
Interventions: OTHER: hyperinsulinemic-hypoglycemic clamp|OTHER: 13C-MRS procedure/Acetate infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Dose Escalation Study of Intranasal Neuropeptide Y in Post Traumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: Neuropeptide Y
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Spinal or Intravenous Dexmedetomidine in Ambulatory Surgery
Status: COMPLETED
Conditions: Surgery Ambulatory
Interventions: DRUG: spinal dexmedetomidine 0.5 mcg|OTHER: spinal chloroprocaine 40 mg|DRUG: IV dexmedetomidine 0.5 mcg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinical Study to Assess the Equivalence of Tranexamic Acid vs Oxytocin in Reducing the PPH (TRANOXY2015)
Status: WITHDRAWN
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Tranexamic Acid|DRUG: Tranexamic Acid|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Hoya SYNC III Design Lenses
Status: COMPLETED
Conditions: Computer Vision Syndrome
Interventions: DEVICE: SYNC III|DEVICE: single vision lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Biliary Drainage in Resectable Pancreatic or Periampullary Cancer
Status: COMPLETED
Conditions: Pancreatic Carcinoma
Interventions: DEVICE: WallFlex™ Biliary RX Fully Covered/Uncovered Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Catheter-based Renal Denervation Using the Vessix™ Renal Denervation System in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Patients With Severe Debilitating Pain
Status: WITHDRAWN
Conditions: Autosomal Dominant Polycystic Kidney Disease
Interventions: DEVICE: Vessix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Efficacy and Safety of Tafasitamab With Bendamustine (BEN) Versus Rituximab (RTX) With BEN in Adult Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL)
Status: COMPLETED
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: Rituximab (RTX)|DRUG: Tafasitamab|DRUG: Bendamustine (BEN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Folrex in the Superior Extremity Rehabilitation After Acute Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: Folrex|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Specialized Food Plan Based on Individual Physiological Comprehensive Body Assessments Accompanied With Cellular Repair Therapy to Decrease Inflammation Cognitively Impaired Patients
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Alzheimer Disease
Interventions: DIETARY_SUPPLEMENT: Mito-Food Plan|OTHER: Cellular Repair Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Adalimumab in MPS I, II, and VI
Status: ACTIVE_NOT_RECRUITING
Conditions: Mucopolysaccharidosis I|Mucopolysaccharidosis II|Mucopolysaccharidosis VI
Interventions: DRUG: Adalimumab Injection [Humira]|DRUG: Saline Solution for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Conversion to Everolimus From Calcineurin Inhibitor With Mycophenolic Acid: Impact on Long Term Renal Function in Liver Transplantation.
Status: COMPLETED
Conditions: Immunosuppression|Renal Failure
Interventions: DRUG: Arm A: Everolimus|DRUG: Calcineurin Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Yangzheng Compound Mixture in the Treatment of Sleep Disorder in Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma|Sleep Disorder
Interventions: DRUG: Yangzheng Compound Mixture|OTHER: Conventional Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing
Status: RECRUITING
Conditions: Solid Tumor, Adult|Colorectal Cancer|Non Small Cell Lung Cancer|Pancreatic Cancer|CRC|NSCLC|Pancreas Cancer|Mesothelioma|Ovarian Cancer|Ovarian Neoplasms|Ovarian Carcinoma|Mesothelioma, Malignant|Mesothelioma; Lung|Cancer
Interventions: OTHER: Apheresis|DIAGNOSTIC_TEST: Next Generation Sequencing (NGS)|DIAGNOSTIC_TEST: Long Range NGS HLA typing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Validation of a System Using Aerosol Glycerine to Detect and Localize Intraoperatively Pulmonary Air Leaks
Status: RECRUITING
Conditions: Air Leak From Lung
Interventions: DIAGNOSTIC_TEST: Air Leaks: Aerosol glycerine System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Use of Neuromuscular Blocking Agents and Neuromuscular Monitoring in 7 Danish Teaching Hospitals
Status: COMPLETED
Conditions: Neuromuscular Blockade
Interventions: DRUG: Rocuronium|DRUG: Succinylcholine|DRUG: Cisatracurium|DRUG: Mivacurium|DEVICE: Objective neuromuscular monitoring (acceleromyography)|DRUG: Sugammadex|DRUG: Neostigmine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Surgery Plus Intraoperative Peritoneal Hyperthermic Chemotherapy (IPHC) to Treat Peritoneal Carcinomatosis
Status: UNKNOWN
Conditions: Stomach Neoplasms|Colorectal Neoplasms|Neoplasm Metastasis|Mesothelioma
Interventions: PROCEDURE: cytoreductive surgery|PROCEDURE: intraoperative peritoneal hyperthermic chemotherapy with cisplatin and mitomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Early Time Restricted Feeding and Timed Light Therapy to Improve Glycemic Control in Adults With Type 2 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Time Restricted Feeding|Light; Therapy, Complications
Interventions: BEHAVIORAL: No change in meal timing|BEHAVIORAL: No change in light exposure|BEHAVIORAL: Early Time-Restricted Feeding|BEHAVIORAL: Timed Light Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Safety and Efficacy of FB-1603 in Hepatocellular Carcinoma Patient Receiving Transarterial Chemoembolization
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Placebo|DRUG: FB-1603
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Dabigatran and Phenprocoumon on ADP Induced Platelet Aggregation in Patients With Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Dabigatran|DRUG: Phenprocoumon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TearCare System to Treat Dry Eye Disease
Status: RECRUITING
Conditions: Dry Eye|Meibomian Gland Dysfunction
Interventions: DEVICE: TearCare|DEVICE: LipiFlow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TFL vs MOSES Holmium Laser in the En-bloc Resection of Bladder Tumors
Status: RECRUITING
Conditions: Urolithiasis of Bladder
Interventions: DEVICE: TFL|DEVICE: MOSES holmium laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel
Status: WITHDRAWN
Conditions: Melasma
Interventions: DRUG: Glycolic acid peel alone|DRUG: Glycolic and salicylic acid peel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Liposomal Curcumin in Combination With RT and TMZ in Patients With Newly Diagnosed High-Grade Gliomas
Status: RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: Concurrent CRT Period|DRUG: Post-CRT Period|DRUG: Adjuvant Period
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Four Versus Six Cycles of Cyclophosphamide/Doxorubicin or Paclitaxel in Adjuvant Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: AC regimen|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomised Trial Comparing Metal and Plastic Biliary Stents Stents for Palliating Malignant Jaundice
Status: UNKNOWN
Conditions: Biliary Obstruction
Interventions: DEVICE: SEMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Xalacom And Xalatan In Patients With Primary Open Angle Glaucoma (POAG) Or Ocular Hypertension (OH).
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: Xalatan|DRUG: Xalacom
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Small Sample，Unicentric，Randomized, Controlled Clinical Study of Coenzyme I for Injection in the Treatment of Sudden Sensorineural Hearing Loss
Status: UNKNOWN
Conditions: Sudden Sensorineural Hearing Loss
Interventions: DRUG: Coenzyme I for Injection + conventional treatment|DRUG: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: BreEStim for Motor Recovery in Chronic Stroke With Moderate Impairment After a Long-term Use (Pilot).
Status: NOT_YET_RECRUITING
Conditions: Motor Recovery
Interventions: DEVICE: BreEStim|DEVICE: EStim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Accuracy of Pre-existing Risk Scoring Models for Predicting Acute Kidney Injury in Patients Who Underwent Aortic Surgery Using a Gray Zone Approach
Status: COMPLETED
Conditions: Aortic Surgery|Postoperative Acute Kidney Injury
Interventions: PROCEDURE: elective or emergency aortic surgery (including ascending, arch, descending thoracic aorta)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluate the Safety and Explore Efficacy of Umbilical Cord Mesenchymal Stem Cells in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: BIOLOGICAL: Allogeneic umbilical cord mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of RO5024048 in Combination With Ritonavir-Boosted Danoprevir and Pegasys/Copegus in Patients With Chronic Hepatitis C Genotype 1 Who Have Failed Prior HCV Protease Inhibitor Treatment
Status: WITHDRAWN
Conditions: Hepatitis C, Chronic
Interventions: DRUG: RO5024048|DRUG: RO5024048|DRUG: danoprevir|DRUG: peginterferon alfa-2a [Pegasys]|DRUG: ribavirin [Copegus]|DRUG: ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of INCB039110 in Combination With Docetaxel in Subjects With Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: NSCLC (Non-small Cell Lung Carcinoma)
Interventions: DRUG: Itacitinib|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REP 2139-Mg and REP 2165-Mg Combination Therapy in Chronic Hepatitis B Infection
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: REP 2139-Mg|DRUG: Pegasys|DRUG: Viread|DRUG: REP 2165-Mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sacubitril Valsartan in Preventing the Recurrence of Atrial Fibrillation After Ablation in Elderly Hypertensive Patients With Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation Recurrent|Hypertension
Interventions: DRUG: Sacubitril-valsartan|DRUG: Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plaque Removal Effectiveness of a Flossing Device Compared to the Conventional Flossing in Adults
Status: COMPLETED
Conditions: Tooth Decay|Cavities of Teeth|Gingivitis|Plaque
Interventions: DEVICE: Dental Floss Holders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Phonophoresis in Subacromial Impingement Syndrome.
Status: COMPLETED
Conditions: Subacromial Impingement Syndrome
Interventions: DEVICE: phonophoresis therapy with pulsed mode ultrasound|DEVICE: phonophoresis therapy with continuous mode ultrasound|DEVICE: sham ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An Open Label Study To Assess The Safety And Tolerability Of BEMA® Buprenorphine NX In Opioid Dependent Subjects
Status: COMPLETED
Conditions: Opioid Dependence
Interventions: DRUG: BEMA Buprenorphine NX films
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Regorafenib for Urothelial Cancer Following Chemotherapy (UAB 1477)
Status: COMPLETED
Conditions: Urothelial Cancer (Urinary Bladder, Ureters, or Renal Pelvis Cancer)
Interventions: DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FMT in the Treatment of IBS
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: OTHER: Fecal Microbiota Transplantation (FMT)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging Study to Investigate the Safety and Diagnostic Performance of rhPSMA 7.3 (18F) in Newly Diagnosed Prostate Cancer (LIGHTHOUSE)
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: rhPSMA-7.3 (18F) Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Cardamom and Fennel on Salivary pH and Anti Microbial Activity
Status: COMPLETED
Conditions: Electrolyte Disturbance|Saliva Altered
Interventions: BIOLOGICAL: cardamom|BIOLOGICAL: fennel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: This is a Study of Efficacy and Safety of Two Secukinumab Dose Regimens in Subjects With Moderate to Severe Hidradenitis Suppurativa (HS).
Status: COMPLETED
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: secukinumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PET/CT and Lymph Node Mapping in Finding Lymph Node Metastasis in Patients With High-Risk Endometrial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Clear Cell Adenocarcinoma|Endometrial Mixed Adenocarcinoma|Endometrial Serous Adenocarcinoma|Grade 3 Endometrial Endometrioid Adenocarcinoma|Malignant Mixed Mesodermal (Mullerian) Tumor
Interventions: PROCEDURE: Computed Tomography|DRUG: Indocyanine Green Solution|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Lymph Node Mapping|PROCEDURE: Lymphadenectomy|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Use of Erythromycin in Mustard-Induced Bronchiolitis
Status: COMPLETED
Conditions: Bronchiolitis Obliterans|Acute Obliterating Bronchiolitis
Interventions: DRUG: Erythromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Determine the Efficacy of Intravenous Ibuprofen for Pain Control Following Arthroscopic Knee Surgery
Status: COMPLETED
Conditions: Arthroscopic Knee Surgery
Interventions: DRUG: IV ibuprofen|DRUG: IV ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tuberosity Versus Palatal Donor Site for Subepithelial Connective Tissue Graft in Root Coverage Therapy (TOPGRAFT)
Status: UNKNOWN
Conditions: Gingival Recession
Interventions: PROCEDURE: Sub-epithelial connective tissue graft harvested from the palatal for root coverage procedure|PROCEDURE: Sub-epithelial connective tissue graft harvested from the tuberosity for root coverage procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Safety and Efficacy of UCART Targeting CS1 in Patients With Relapsed/Refractory Multiple Myeloma (MELANI-01)
Status: TERMINATED
Conditions: Relapsed/Refractory Multiple Myeloma
Interventions: BIOLOGICAL: UCARTCS1A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Boiled Peanut Oral Immunotherapy for the Treatment of Peanut Allergy: a Pilot Study
Status: COMPLETED
Conditions: IgE Mediated Peanut Allergy
Interventions: OTHER: Desensitisation using boiled peanut|OTHER: Desensitisation using boiled peanut (deferred start)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GastroIntestinal Cancer in Children and Adolescents
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastrointestinal Cancer|Colorectal Cancer|Gastric Cancer|Hepatoblastoma|Hepatocellular Carcinoma|Burkitt Lymphoma|Neuroendocrine Tumors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SHIELD Study: Using Naso-oropharyngeal Antiseptic Decolonization to Reduce COVID-19 Viral Shedding
Status: COMPLETED
Conditions: COVID-19|SARS-CoV 2
Interventions: DRUG: 10% Povidone-iodine nasal decolonization swab plus 0.12% CHG oral rinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: HIV and Alcohol Research Center Focused on Polypharmacy (HARP) Pilot 2 (2nd HARP Pilot Intervention)
Status: NOT_YET_RECRUITING
Conditions: Hiv|Alcohol Drinking|Fall|Cannabis Use
Interventions: BEHAVIORAL: Information Motivation Behavioral and Motivational Interviewing (IMB-MI) technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Early Lactate Dosage Compared to CK for Diagnosis of a Suspected Seizure
Status: UNKNOWN
Conditions: Epileptic Seizure|Creatine Kinase|Lactate|Epileptic Generalized Tonic-clonic Seizure
Interventions: DIAGNOSTIC_TEST: CK and Lactate dosages
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Investigate the Effect of Itraconazole on the PK of Multiple Doses of Balovaptan in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Balovaptan|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Superior vs Temporal Laser Peripheral Iridotomy in Primary Angle Closure Suspects (PACS)
Status: RECRUITING
Conditions: Primary Angle Glaucoma Closure Suspect
Interventions: PROCEDURE: Yag Laser peripheral Iridotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: OPTImaL:Optimisation of Treatment for Patients With Low Stage Triple-negative Breast Cancer With High Stromal Tumor-infiltrating Lymphocytes
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer Stage I|Triple Negative Breast Cancer (TNBC)
Interventions: DRUG: Adjuvant chemotherapy|OTHER: No adjuvant chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Post-operative Pain After Total Pulpotomy and Root Canal Treatment
Status: COMPLETED
Conditions: Post-operative Pain|Pulpitis - Irreversible
Interventions: PROCEDURE: Total pulpotomy|PROCEDURE: Root canal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: An International Non-interventional Cohort Study to Evaluate the Safety of Treatment With Insulin Detemir in Pregnant Women With Diabetes Mellitus. Diabetes Pregnancy Registry
Status: COMPLETED
Conditions: Diabetes Mellitus|Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin detemir|DRUG: other injectable antidiabetic treatment regimens
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tract-based Artificial Intelligence (AI) Robot Guiding System in Basal Ganglion Hemorrhage Evacuation
Status: NOT_YET_RECRUITING
Conditions: Basal Ganglia Hemorrhage
Interventions: PROCEDURE: Minimally invasive basal ganglion hematoma evacuation with Tract-based AI Robot Guiding System|DRUG: "Hemocoagulase Bothrops Atrox for Injection"；"Nicardipine"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Roll-over After 3-year Trial for Tenofovir in Mild Chronic Hepatitis B
Status: UNKNOWN
Conditions: Chronic Hepatitis B|Antiviral Treatment
Interventions: DRUG: Tenofovir Disoproxil Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Italian Multicenter Study Comparing FOLFOXIRI Versus Gemcitabine as Adjuvant Treatment for Resected Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: DRUG: FOLFOXIRI|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT