pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparative Study of Biologic Mesh Versus Repair With Component Separation.
Status: TERMINATED
Conditions: Ventral Hernia
Interventions: DEVICE: XenMATRIX mesh|PROCEDURE: Open abdominal ventral hernia repair
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EPIC-ATTR: A Study to Evaluate the Effect of Eplontersen on the Transthyretin Reduction and Long-term Safety in Chinese Subjects With Transthyretin Amyloid Cardiomyopathy
Status: RECRUITING
Conditions: Transthyretin Amyloid Cardiomyopathy
Interventions: DRUG: Eplontersen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Evaluation of Immunotoxin LMB-100 Administered by Normothermic, Intrapleural Perfusion Following Cytoreductive Surgery in Participants With Pleural Mesotheliomas, or Pleural Effusions From Cancers Expressing Mesothelin
Status: WITHDRAWN
Conditions: Malignant Pleural Mesotheliomas (Mpm)|Malignant Pleural Effusions (Mpe)|Epithelial Tumors, Malignant|Pleural Effusions, Malignant|Mesothelin (Msln)
Interventions: PROCEDURE: Cytoreductive surgery|DRUG: LMB-100|DIAGNOSTIC_TEST: Immunohistochemical Assay for Mesothelin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Root Resorption in Class II Div 1 Malocclusion in Upper 1st Premolar Extraction vs Distalization
Status: RECRUITING
Conditions: Class II Div 1 Malocclusion
Interventions: PROCEDURE: maxillary Ist premolar extraction|PROCEDURE: SURGICAL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cytoreductive Prostatectomy Combined With Triple or Dual Systemic Therapy in mHSPC Patients
Status: RECRUITING
Conditions: Metastatic Prostate Cancer|Therapy, Directly Observed
Interventions: PROCEDURE: Cytoreductive prostatectomy or brachytherapy|DRUG: ADT+second-generation antiandrogens ± chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bronchoscopy Study to Assess the Effects of Inhaled Corticosteroids on Adult Healthy Volunteers
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DRUG: Fluticasone propionate|DEVICE: Accuhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate Pharmacokinetic Parameters of Eliglustat in Healthy Volunteers Who Are CYP2D6 Extensive or Poor Metabolizers
Status: COMPLETED
Conditions: Gaucher's Disease
Interventions: DRUG: Eliglustat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase I Dose-finding and Preliminary Efficacy Study of the Istodax® in Combination With Doxil® for the Treatment of Adults With Relapsed or Refractory Cutaneous T-cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma|T-Cell Lymphoma|Cutaneous Lymphoma
Interventions: DRUG: Istodax|DRUG: Doxil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two-channel IV-PCA With Dexmedetomidine
Status: RECRUITING
Conditions: Analgesia, Patient-Controlled|Dexmedetomidine
Interventions: DRUG: Dexmedetomidine|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Repaglinide and Metformin Combination Therapy in Type 2 Diabetes Failing on Oral Anti-diabetic Drugs
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: repaglinide|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protective Ventilation With High Versus Low PEEP During One-lung Ventilation for Thoracic Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: One-Lung Ventilation
Interventions: PROCEDURE: PEEP level|PROCEDURE: Use of recruitment maneuvers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quality Assessment of Orotracheal Intubation Without Neuromuscular Blocking Agents in Obese Patients
Status: COMPLETED
Conditions: Obesity|Bariatric Surgery Candidate|Intubation Complication
Interventions: DRUG: Remifentanil Injection|DRUG: Remifentanil Injection plus 30%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term, High Blood Flow Hemoadsorption Therapy in Patients Undergoing Maintenance Hemodialysis
Status: RECRUITING
Conditions: Chronic Kidney Diseases|Hemodialysis
Interventions: OTHER: long-term, high blood flow hemoadsorption therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in Plerixafor and Granulocyte-colony Stimulating Factor Patients With Relapse Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Plerixafor granulocyte-colony stimulating factor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relation Between Aldosterone and Cardiac Remodeling After Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: BIOLOGICAL: blood sample|PROCEDURE: MRI|PROCEDURE: echocardiography|BIOLOGICAL: urine sample|PROCEDURE: pulmonary echography|PROCEDURE: vascular check|PROCEDURE: renal echography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mapracorat Ophthalmic Suspension for the Treatment of Ocular Inflammation Following Cataract Surgery
Status: COMPLETED
Conditions: Cataract
Interventions: DRUG: Mapracorat|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Substudy of Protocol 2019-002498-80 - NCT04223050: Comparing Mortality for Low vs High Peripheral Oxygen Saturation in COPD-patients With Acute Exacerbation (O2flow-COPD)
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodal Management of Neck and Back Pain in the Emergency Department (Multi-ED)
Status: COMPLETED
Conditions: Musculoskeletal Pain
Interventions: BEHAVIORAL: Psychologically-Informed Physical Therapy (PIPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media
Status: COMPLETED
Conditions: Acute Otitis Media
Interventions: DEVICE: Tympanostomy tube placement|DRUG: Amoxicillin-Clavulanate and/or Ceftriaxone|DRUG: Ofloxacin Otic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melphalan and Busulfan Followed By Donor Peripheral Stem Cell Transplant, Tacrolimus, and Methotrexate in Treating Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: busulfan|DRUG: melphalan|DRUG: methotrexate|DRUG: tacrolimus|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Type-2 Diabetic Patients Treated With Insulin During the Ramadan
Status: COMPLETED
Conditions: Diabetes Type 2|Treatment During Ramadan
Interventions: DRUG: Insulin treatment during Ramadan|DRUG: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SPI-1005 Treatment in Moderate COVID-19 Patients
Status: ENROLLING_BY_INVITATION
Conditions: Covid19|Corona Virus Infection|Coronavirus|Coronavirus Infection
Interventions: DRUG: Ebselen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: the Pathophysiology of the Onset of Atrial Fibrillation in Obstructive Sleep Apnea
Status: ENROLLING_BY_INVITATION
Conditions: Atrial Fibrillation|Obstructive Sleep Apnea of Adult
Interventions: DIAGNOSTIC_TEST: Polysomnography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Management of Pruritus With Xyzal in Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis|Pruritus
Interventions: DRUG: Levocetirizine dihydrochloride (Xyzal)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Effects of Combined Kinesiotaping and Steroid Injection in Stroke Patients With Hemiplegic Shoulder Pain
Status: RECRUITING
Conditions: Stroke|Hemiplegic Shoulder Pain
Interventions: OTHER: Kinesiotaping|OTHER: Hand rehabilitation program|OTHER: Steroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Children of Mentally Ill Parents-Network - CHIMPS-NET
Status: RECRUITING
Conditions: Mental Health Issue
Interventions: BEHAVIORAL: CHIMPS-T|BEHAVIORAL: CHIMPS-P|BEHAVIORAL: CHIMPS-MFT-group|BEHAVIORAL: iCHIMPS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fuzheng Nizeng Formula for Chronic Atrophic Gastritis With Low-grade Intraepithelial Neoplasia, a Multicenter Randomized Controlled Trial
Status: RECRUITING
Conditions: Atrophic Gastritis With Low-grade Intraepithelial Neoplasia
Interventions: DRUG: Fuzhegn Nizeng Decoction|DRUG: Moluodan granules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK of MMF in Cadaveric vs Living Donor Liver Transplant Recipients
Status: COMPLETED
Conditions: Transplantation, Liver
Interventions: PROCEDURE: Serial blood sampling as described in protocol|PROCEDURE: Estimation of Creatinine Clearance at regular intervals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can an Educational Intervention Targeting General Practitioners Increase HPV Vaccination Coverage in AuRA_Lyon (France)
Status: UNKNOWN
Conditions: Human Papillomavirus Vaccination
Interventions: BEHAVIORAL: Educational workshop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: A Trial of SHR-1210 in Combination With Apatinib in Patients With Unresectable HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: SHR1210|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bcl-2 Inhibitors Combined With Azacytidine and Chemotherapy in Elderly Patients With Previously Untreated AML
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Venetoclax|DRUG: Azacitidine|DRUG: Cladribine|DRUG: Cytarabine|DRUG: Idarubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Vitamin D as An Adjuvant Treatment in Children With Chronic Idiopathic Thrombocytopenic Purpura
Status: NOT_YET_RECRUITING
Conditions: Immune Thrombocytopenia
Interventions: DRUG: VIT D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Promoting Healing of Injured Nerves With Electrical Stimulation Therapy
Status: RECRUITING
Conditions: Nerve Injury|Peripheral Nerve Injuries|Peripheral Nerve Injury Upper Limb|Nerve Palsy
Interventions: DEVICE: Checkpoint BEST System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Moderate Inspired Oxygen Fraction (FiO2) and Protective Ventilation on Postoperative Pulmonary Complication
Status: UNKNOWN
Conditions: Hepatectomy
Interventions: OTHER: Moderate FiO2 and Protective Lung Ventilation Using
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Oral Picoplatin With Intravenous Picoplatin in Subjects With Solid Tumors
Status: COMPLETED
Conditions: Bladder Cancer|Breast Cancer|Colorectal Cancer|Gastrointestinal Neoplasm|Head and Neck Cancer|Lung Cancer|Ovarian Cancer|Pancreatic Cancer|Prostate Cancer
Interventions: DRUG: Picoplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-FSPG PET/CT in Imaging Patients With Newly Diagnosed Lung Cancer or Indeterminate Pulmonary Nodules
Status: COMPLETED
Conditions: Lung Carcinoma|Solitary Pulmonary Nodule|Cigarette Smoking Behavior
Interventions: PROCEDURE: Computed Tomography|PROCEDURE: Computed Tomography|RADIATION: fluorodeoxyglucose F-18|DRUG: Fluorine F 18 L-glutamate Derivative BAY94-9392|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Positron Emission Tomography|PROCEDURE: Positron Emission Tomography (PET)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Aspirin Combined With Clopidogrel Versus Intravenous Alteplase for Acute Minor Stroke
Status: NOT_YET_RECRUITING
Conditions: Ischemic Stroke
Interventions: DRUG: Aspirin|DRUG: Clopidogrel|DRUG: Alteplase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of PRN and Every 2months Intravitreal Aflibercept for Age Related Macular Degeneration
Status: COMPLETED
Conditions: Age-related Macular Degeneration
Interventions: DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Building Sentences With Preschoolers Who Use AAC
Status: COMPLETED
Conditions: Down Syndrome|Speech and Language Disorder|Speech Disorders in Children|Speech Intelligibility|Speech Sound Disorder
Interventions: BEHAVIORAL: AAC Generative Language Intervention|BEHAVIORAL: Standard of Care / Business as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thermosensitive Gels for the Vaginal Delivery of Sildenafil Citrate
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: preparation F12 sildenafil in situ gel|DRUG: preparation F2 sildenafil in situ gel|DRUG: placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Carnitine and Liver Mitochondria Fatty Acid Processing
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Insulin Resistance|Obesity
Interventions: DIETARY_SUPPLEMENT: L-Carnitine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Chemotherapy Treatment in Re-occurring Non Small Cell Lung Cancer (NSCLC) After Previous Chemotherapy and Surgical Removal of the NSCLC Tumor
Status: TERMINATED
Conditions: Lung Neoplasms
Interventions: DRUG: pemetrexed|DRUG: gemcitabine|DRUG: carboplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Efficacy of CAR-T Cells in the Treatment of Refractory Myasthenia Gravis
Status: RECRUITING
Conditions: Myasthenia Gravis
Interventions: DRUG: CD19 CAR-T cells injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adolescents' Health Through Mobile Apps, Wearables, and a Gamified TAC ( ActivA-App )
Status: NOT_YET_RECRUITING
Conditions: Adolescent Behavior|Physical Activity|New Technologies
Interventions: BEHAVIORAL: "PACER" Application|BEHAVIORAL: "MapMyWalk" Application|BEHAVIORAL: "Strava" Application|BEHAVIORAL: "POKEMON GO" APPLICATION|BEHAVIORAL: "JEFIT" APPLICATION|BEHAVIORAL: "FITBIT-FLEX" APPLICATION|BEHAVIORAL: "MEIZU BONG 2S" APPLICATION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intrauterine Antibiotic Infusion in Treating Chronic Endometritis and Restoring Reproductive Dynamics
Status: COMPLETED
Conditions: Chronic Endometritis
Interventions: DRUG: Oral antibiotic administration|DRUG: Intrauterine antibiotic infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of VG161 Combined With Nivolumab Injection in Patients With Advanced Metastatic Gastric Cancer
Status: RECRUITING
Conditions: Metastatic Gastric Cancer
Interventions: DRUG: Recombinant Human IL12/15-PDL1B Oncolytic HSV-1 Injection (Vero Cell))|DRUG: Nivolumab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential Left Prefrontal Repetitive Transcranial Magnetic Stimulation, With High Frequency, for Treatment-Resistant Depression
Status: UNKNOWN
Conditions: Treatment-Resistant Depression Disease
Interventions: OTHER: Repetitive Transcranial Magnetic Stimulation|OTHER: Sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Intensity Interval Training Versus Moderate Continuous Training in Heart Failure With Preserved Ejection Fraction
Status: COMPLETED
Conditions: Heart Failure|Diastolic Heart Failure
Interventions: BEHAVIORAL: High Intensity Interval Training|BEHAVIORAL: Moderate Continuous Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modification of Endometrial Receptivity After Vaginal Seminal Plasma Application
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Receptivity
Interventions: OTHER: seminal plasma|OTHER: saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-VEGF Therapy Versus Dexamethasone Implant for DME
Status: UNKNOWN
Conditions: Clinically Significant Macular Edema Due to Diabetes Mellitus
Interventions: DRUG: Aflibercept,|DRUG: Ranibizumab Injection|DRUG: Ozurdex Drug Implant Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Testing A Radioactive Compound Given Through A Vein With And Without The Non-Radioactive Compound, Given By Mouth, To Characterize Tissue Distribution Using Positron Emission Tomography Scanning
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: [11C]PF-06427878|DRUG: PF-06427878 10 mg|DRUG: PF-06427878 600 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immunological Persistence After Priming With GSK1024850A Vaccine and Safety& Immunogenicity After Booster Dose
Status: COMPLETED
Conditions: Infections, Streptococcal
Interventions: BIOLOGICAL: Pneumococcal vaccine GSK1024850A|BIOLOGICAL: Infanrix-IPV/Hib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Adenosine Cardioplegia; Improved Cardioprotection?
Status: COMPLETED
Conditions: Angina Pectoris
Interventions: DRUG: Adenosine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of High Flow Nasal Cannula vs. Standard Care on Respiratory Stability in Pediatric Procedural Sedation
Status: COMPLETED
Conditions: Respiratory Insufficiency
Interventions: OTHER: High Flow nasal cannula|OTHER: Standard respiratory care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Tai Chi and Pilates for Individuals With Prediabetes
Status: NOT_YET_RECRUITING
Conditions: PreDiabetes
Interventions: OTHER: Pilates Exercises Group|OTHER: Tai Chi Exercises Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab-PET Imaging
Status: COMPLETED
Conditions: Melanoma|Non-small Cell Lung Cancer
Interventions: DRUG: 89Zr-Pembrolizumab|DEVICE: 89Zr-Pembrolizumab PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Enhancement of a Psychotherapeutic Intervention Through Transcranial Direct Current Stimulation (tDCS)
Status: RECRUITING
Conditions: Psychiatric Disorder
Interventions: DEVICE: Active tDCS|BEHAVIORAL: Assertiveness Training Program (ATP)|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Timing on the Efficacy of Zegerid 40 mg in Healing Reflux Esophagitis: A Pilot Study
Status: COMPLETED
Conditions: Erosive Esophagitis
Interventions: DRUG: Omeprazole/sodium bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Treatment of Reticular Veins
Status: COMPLETED
Conditions: Varicose Veins
Interventions: DRUG: Polidocanol with Glucose|DRUG: Glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Local Infiltration Analgesia in Bilateral Knee Arthroplasty - Efficacy of Subcutaneous Wound Infiltration With Local Anesthetic
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: ropivacaine 0.2%, 50 mL|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Basal Insulin Administration in Adult Diabetic Ketoacidosis Management
Status: TERMINATED
Conditions: Diabetic Ketoacidosis|Type 1 Diabetes|Type 2 Diabetes
Interventions: DRUG: Early Glargine|DRUG: Late Glargine|OTHER: IV insulin infusion|OTHER: IV fluid and electrolytes replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IX-01 Effect on Intravaginal Ejaculatory Latency Time (IELT) and Patient Reported Outcomes in Men With Premature Ejaculation (PE)
Status: COMPLETED
Conditions: Premature Ejaculation
Interventions: DRUG: IX-01|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D Oral Supplementation in Poly Csytic Ovarian Women Resistant to Clomiphene Citrate
Status: UNKNOWN
Conditions: Vitamin D Deficiency|Clomiphene Allergy|Polycystic Ovary Syndrome
Interventions: DRUG: Vitamin D|DRUG: Clomid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Of External Physical Vibration Lithecbole(EPVL) In Different Time After Retrograde Intrarenal Surgery(RIRS)
Status: COMPLETED
Conditions: Calculi
Interventions: PROCEDURE: 3 days after|PROCEDURE: 10days after|PROCEDURE: EPVL performed in30days after RIRS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nonalcoholic Steatohepatitis in HIV Mono-infection: Exploring Non-invasive Methods for Diagnosis and the Therapeutic Role of Vitamin E
Status: COMPLETED
Conditions: HIV Mono Infection
Interventions: DIETARY_SUPPLEMENT: Vitamin E
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Study Comparing Osimertinib Monotherapy to Combination Therapy With Osimertinib,Carboplatin and Pemetrexed for Untreated Patients With Advanced Non-squamous Non-Small Cell Lung Cancer With Concurrent EGFR and TP53 Mutations
Status: UNKNOWN
Conditions: Non-small Cell Carcinoma|EGFR Gene Mutation
Interventions: DRUG: Osimertinib 80 MG [Tagrisso]|DRUG: Pemetrexed 500 MG Injection|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of TU-100 on Gastrointestinal and Colonic Transit in Humans
Status: COMPLETED
Conditions: Postoperative Ileus
Interventions: DRUG: Daikenchuto (TU-100)|DRUG: Daikenchuto (TU-100)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: SBRT for Close or Positive Margins After Resection of Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Adenocarcinoma of the Pancreas
Interventions: RADIATION: Stereotactic Body Radiation Therapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2b Study of Taxol Plus Sorafenib or Placebo in Patients With Advanced Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: paclitaxel|DRUG: sorafenib tosylate|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects Of Pilates-Based Tele-Exercise In Primary Dysmenorrhea
Status: NOT_YET_RECRUITING
Conditions: Primary Dysmenorrhea
Interventions: OTHER: pilates-based tele-exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Patients With Bone Tissue Defects Using Mesenchymal Stem Cells Enriched by Extracellular Vesicles
Status: UNKNOWN
Conditions: Segmental Fracture - Bone Loss
Interventions: BIOLOGICAL: Mesenchymal stem cells enriched by extracellular vesicles|OTHER: Standard treatment of bone defects
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shockwave Phonophoresis on Calcaneal Spur Patients
Status: UNKNOWN
Conditions: Calcaneal Spur
Interventions: DEVICE: Acetic acid shockwave phonophoresis therapy|DEVICE: Shock wave Therapy|OTHER: conventional physical therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Collaboration for Antepartum Risk Evaluation
Status: COMPLETED
Conditions: Prenatal Care|Maternal-child Health Services|Maternal Health Services|Perinatal Care|Midwifery
Interventions: BEHAVIORAL: Collaborative Care|BEHAVIORAL: Comparison Care- Usual Care + primary midwife
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Demonstrate the Bioequivalence of Lacosamide Tablets and Dry Syrup in Healthy Male Japanese Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Lacosamide (LCM) tablet|DRUG: Lacosamide (LCM) dry syrup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity & Reactogenicity of Various Formulations of Recombinant Hepatitis B Vaccine With Different Adjuvants
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Engerix™-B|BIOLOGICAL: HBV-MPL vaccine (208129)|BIOLOGICAL: Hepatitis B vaccine, experimental formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Vaccine Therapy in Treating Patients With Stage IV or Recurrent Malignant Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: dendritic cell-MART-1 peptide vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Type I Diabetes and Non-surgical Periodontal Treatment
Status: NOT_YET_RECRUITING
Conditions: Type 1 Diabetes|Periodontitis|Periodontal Diseases|Diabetes|Diabetes Mellitus|Diabetes Mellitus, Type 1
Interventions: PROCEDURE: Non-surgical periodontal therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ivabradine on Patients With Postural Orthostatic Tachycardia Syndrome
Status: COMPLETED
Conditions: Postural Orthostatic Tachycardia Syndrome
Interventions: DRUG: Ivabradine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Using Tranexamic Acid to Reduce Blood Loss In Simultaneous Bilateral Total Knee Arthroplasty
Status: COMPLETED
Conditions: Blood Loss
Interventions: DRUG: Tranexamic Acid|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SymptomCare@Home: Deconstructing an Effective Symptom Management Intervention
Status: COMPLETED
Conditions: Cancer
Interventions: BEHAVIORAL: SCC|BEHAVIORAL: Nurse Practitioner|BEHAVIORAL: DSS|BEHAVIORAL: AT|BEHAVIORAL: Symptom Severity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Early Weaning of Preterm Newborn From Incubator to Cot at 1400 Grams
Status: UNKNOWN
Conditions: Pre-Term|Body Temperature Changes|Transition|Patient Discharge|Length of Stay
Interventions: DEVICE: Weaning to crib|DEVICE: Weaning from incubator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CESA 5.10 Investigation to Compare the Efficacy and Safety of the Adacolumn® Apheresis Device in Patients With Active Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DEVICE: Adacolumn®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Making Activity Time for Cognitive Health
Status: COMPLETED
Conditions: Breast Cancer|Cancer-related Problem/Condition|Cognitive Impairment|Physical Activity
Interventions: BEHAVIORAL: Walking for 10 minutes|BEHAVIORAL: Walking for 20 minutes|BEHAVIORAL: Walking for 30 minutes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fractional Laser Versus Radiofrequency in Androgenetic Alopecia
Status: UNKNOWN
Conditions: Androgenic Alopecia
Interventions: PROCEDURE: FCO2|PROCEDURE: FRF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy And Safety Of Smoking Cessation With Varenicline Tartrate In Diabetic Smokers: (DIASMOKE)
Status: COMPLETED
Conditions: Smoking Cessation|Diabetes
Interventions: DRUG: varenicline|DRUG: placebo tablet is made of lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Multiple Therapies in Biomarker-Selected Patients With Resectable Stages IB-III Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Alectinib|DRUG: Entrectinib|DRUG: Vemurafenib (Enrollment closed)|DRUG: Cobimetinib (Enrollment closed)|DRUG: Pralsetinib (Enrollment closed)|DRUG: Atezolizumab|DRUG: SBRT|PROCEDURE: Resection|DRUG: Chemotherapy|DRUG: Divarasib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mussel Intake and Vitamin D Status in Humans
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: No Mussels|DIETARY_SUPPLEMENT: One mussel portion|DIETARY_SUPPLEMENT: Two mussel portions|DIETARY_SUPPLEMENT: Three mussel portions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Role of Periodic Alveolar Recruitment Maneuvers in Intraoperative Protective Ventilation
Status: COMPLETED
Conditions: Mechanical Power|Alveolar Recruitment Maneuvers|Protective Ventilation|Postoperative Pulmonary Complications
Interventions: OTHER: periodic alveolar recruitment maneuvers|OTHER: positive end-expiratory pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: REduced Frequency ImmuNE Checkpoint Inhibition in Cancers
Status: RECRUITING
Conditions: Renal Cell Carcinoma|Melanoma
Interventions: DRUG: Nivolumab|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of CEAG on Inflammation and Endothelial Function
Status: COMPLETED
Conditions: Inflammation|Endothelial Dysfunction
Interventions: DIETARY_SUPPLEMENT: CEAG|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Conventional Vestibular Training Versus Immersive Virtual Reality- Based Vestibular in Multiple Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis|Vestibular Disease|Dizziness|Balance Disorders|Fatigue|Quality of Life|Usability|Cybersickness
Interventions: OTHER: Immersive Virtual-based vestibular rehabilitation|OTHER: Conventional vestibular rehabilitation protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Misoprostol Prior to Office Hysteroscopy in Patients With no Risk Factors for Experiencing Unacceptable Pain
Status: UNKNOWN
Conditions: Pain
Interventions: DRUG: Misoprostol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oral Controlled-Ileocolonic-Release Nicotinamide (CICR-NAM)
Status: NOT_YET_RECRUITING
Conditions: Ulcerative Colitis, Unspecified
Interventions: DRUG: Low-Dose CICR-NAM|DRUG: High-Dose CICR-NAM|DRUG: 0 g/d CICR-NAM (blinded)|DRUG: Open-Label
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of CleaRing Open-capsule Device on Refractive Predictability in Cataract Patients (Part 2)
Status: RECRUITING
Conditions: Posterior Capsule Opacification
Interventions: DEVICE: CleaRing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Risk of Venous Thromboembolism (i.e., Blood Clots in the Veins) and Bleeding Events in a Population of Obese Patients Receiving Higher-Dose or Extended-Duration Versus Conventional-Dose or Conventional-Duration of Prophylaxis (i.e., Preventive Treatment) With Enoxaparin
Status: ACTIVE_NOT_RECRUITING
Conditions: Venous Thromboembolism
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TMC278-TiDP6-C215: A Clinical Trial in Treatment Naive HIV-subjects Patients Comparing TMC278 to Efavirenz in Combination With 2 Nucleoside/Nucleotide Reverse Transcriptase Inhibitors
Status: COMPLETED
Conditions: HIV Infections|HIV-1
Interventions: DRUG: TMC278|DRUG: efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Clinical Efficacy and Safety of Daratumumab in Participants With Relapsed or Refractory Natural Killer/T-Cell Lymphoma (NKTCL), Nasal Type
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tipifarnib in Treating Patients With Metastatic Malignant Melanoma
Status: COMPLETED
Conditions: Recurrent Melanoma|Stage IV Melanoma
Interventions: DRUG: tipifarnib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Different Doses as Adjuvant to Entropy-assisted General Anesthesia During Functional Endoscopy Sinus Surgery.
Status: COMPLETED
Conditions: Pain Management|Dexmedetomidine|Anesthesia
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Imaging Laterality in Chronic Stroke Patients
Status: COMPLETED
Conditions: Stroke|Motor Cortex; Lesion
Interventions: DIAGNOSTIC_TEST: Rasch modified version of the Fugl-Meyer Motor assessment|DIAGNOSTIC_TEST: Anatomical image acquisition|DIAGNOSTIC_TEST: Functional MRI task and acquisition
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Mycograb as Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDS
Status: TERMINATED
Conditions: Cryptococcal Meningitis
Interventions: DRUG: Mycograb|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of a Topical Microemulsion in Patients With Allergic Rhinitis Due to Sensitization to Pollen
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DEVICE: Lipidic Microemulsion|DEVICE: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Onlay Synthetic Bioabsorbable Mesh Herniorrhaphy Versus Herniorrhaphy Only in the Primary Treatment of Large Hiatal Hernia
Status: RECRUITING
Conditions: Large Hiatal Hernia
Interventions: PROCEDURE: Laparoscopic hiatal hernia repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Low Level Laser Therapy and Interferential Current in Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: Active Interferential Current|DEVICE: Active Laser|DEVICE: Placebo Interferential Current|DEVICE: Placebo Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Culturally Grounded Early Substance Use Prevention for American Indian Families
Status: COMPLETED
Conditions: Substance Use
Interventions: BEHAVIORAL: Lakota Language enhancement|BEHAVIORAL: Facebook Supplement|BEHAVIORAL: Substance Use Resistance Skills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety Study of GSK Biologicals' Human Papillomavirus Vaccine in 580299/008 Subjects From Canada or the US
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: BIOLOGICAL: GSK Biological's HPV vaccine GSK580299 (Cervarix™)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Stem Cell Harvesting Using GCSF Plus Plerxiafor, in First -Line, for Heavily Pre- Treated Pediatric Oncology Patients.
Status: UNKNOWN
Conditions: Autologous Stem Cell Transplantation
Interventions: DRUG: Plerixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Lifestyle Intervention vs Physical Therapy Treatment in Patients With Secondary Lymphedema After Cancer
Status: COMPLETED
Conditions: Lymphedema, Secondary
Interventions: OTHER: Physical therapy treatment|BEHAVIORAL: Lifestyle treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Sorafenib in Patients With Chemonaive Metastatic Uveal Melanoma
Status: UNKNOWN
Conditions: Uveal Melanoma
Interventions: DRUG: Placebo|DRUG: Sorafenib|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Geriatric Care Survivorship Intervention for Improving the Overall Health of Older Adults With Stage I-III Breast Cancer Who Have Completed Curative Treatment
Status: RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8
Interventions: OTHER: Comprehensive Geriatric Assessment|BEHAVIORAL: Health Education|OTHER: Medical Device Usage and Evaluation|OTHER: Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: OA Therapy for Mouth-breathers Who Snore
Status: COMPLETED
Conditions: Snoring|Mouth Breathing|Obstructive Sleep Apnea
Interventions: DEVICE: myTAP oral appliance plus mouth shield|DEVICE: myTAP oral appliance alone for first 4 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anthracycline Induced Cardiotoxicity - Early Detection by Combination of Diastolic Strain and T2-mapping
Status: COMPLETED
Conditions: Breast Cancer|Myocardial Damage|Cardiotoxicity
Interventions: DIAGNOSTIC_TEST: Cardiac MRI and echocardiography, laboratory parameters
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Tigerase® Efficacy and Safety as Part of Complex Therapy in Patients With COVID-19
Status: COMPLETED
Conditions: COVID-19|Coronavirus Disease 2019
Interventions: BIOLOGICAL: Tigerase® and best available care|OTHER: Best available care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Failure Analysis of Patellofemoral Arthroplasty
Status: ACTIVE_NOT_RECRUITING
Conditions: Patellofemoral Osteoarthritis|Arthroplasty Complications|Knee Osteoarthritis
Interventions: DEVICE: Patellofemoral arthroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Letrozole Pretreatment With Misoprostol fInduction of Abortion In First-Trimester Missed Miscarriage
Status: UNKNOWN
Conditions: Miscarriage|Missed Abortion
Interventions: DRUG: Letrozole 2.5mg|DRUG: Placebo|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of Ceritinib in Combination With Nivolumab in Patients With ALK-positive Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: ALK-positive NSCLC
Interventions: DRUG: Ceritinib (LDK378)|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT