pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Metabolic Response Following Intake of 2 Metabolic Preconditioning Drinks
Status: COMPLETED
Conditions: Starvation
Interventions: DIETARY_SUPPLEMENT: PreOP Booster|DIETARY_SUPPLEMENT: PreOP (Nutricia Clinical Care, Trowbridge, UK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparing Analgesic Efficacy of Systemic Lidocaine Against Placebo in General Anesthesia in Bariatric Surgery
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Lidocaine Hydrochloride|DRUG: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Computer-based Cognitive Rehabilitation Program for Healthy Older Adults, Older People With Mild Cognitive Impairment and Mild Dementia
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild Cognitive Impairment|Mild Dementia|Healthy Older Adults
Interventions: BEHAVIORAL: Perceptual-based memory encoding|BEHAVIORAL: Semantic-based memory encoding|BEHAVIORAL: Cognitive stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: EndoscoPic Submucosal dIssection Using geL Versus glycerOl for Submucosal iNjection
Status: TERMINATED
Conditions: Early Gastric Cancer|Rectal Polyp
Interventions: PROCEDURE: Endoscopic submucosal dissection|DEVICE: use of Orise Gel as lifting agent for endoscopic submucosal dissection|DEVICE: use of glycerol as lifting agent for endoscopic submucosal dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Comparison Trial Between PCA and Epidural Analgesia for Pectus Excavatum Repair
Status: TERMINATED
Conditions: Pectus Excavatum
Interventions: DRUG: Hydromorphone|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of 2C-B Compared With MDMA and Psilocybin in Healthy Subjects
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: 4-bromo-2,5-dimethoxyphenethylamine (10 mg)|DRUG: 4-bromo-2,5-dimethoxyphenethylamine (20 mg)|DRUG: 4-bromo-2,5-dimethoxyphenethylamine (30 mg)|DRUG: 3,4-methylenedioxymethamphetamine|DRUG: Psilocybin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of the Safety and Efficacy of LCZ696 on Arterial Stiffness in Elderly Patients With Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: LCZ696|DRUG: Olmesartan|DRUG: LCZ696 matching placebo|DRUG: Olmesartan matching placebo|DRUG: amlodipine|DRUG: hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GI Organ Tracking Via Balloon Applicators
Status: WITHDRAWN
Conditions: Esophageal Cancer|Kidney Cancer|Larynx Cancer|Liver Cancer|Lung Cancer|Digestive Organs--Cancer|Intrathoracic--Cancer|Respiratory Organs--Cancer|Pancreas Cancer|Small Intestine Cancer|Stomach Cancer|Colon Cancer|Rectal Cancer
Interventions: DEVICE: Balloon-tipped catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Randomized Trial of Behaviorally Designed Gamification and Social Incentives to Increase Physical Activity Among Overweight and Obese Veterans
Status: ENROLLING_BY_INVITATION
Conditions: Hypertension|Obesity
Interventions: BEHAVIORAL: gamification with collaboration|BEHAVIORAL: gamification with competition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Compassionate Use of an Intravenous Fish Oil Emulsion in the Treatment of Liver Injury in Infants
Status: COMPLETED
Conditions: Cholestasis|Cholestasis of Parenteral Nutrition
Interventions: DRUG: Omegaven
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A New APPROACH to HIV Testing: Adaptation of POCT for Pharmacies to Reduce Risk and Optimize Access to Care in HIV
Status: COMPLETED
Conditions: HIV Infections
Interventions: OTHER: A HIV POCT program adapted for & provided by community pharmacists
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Clinical Trial of Cross-linked Hyaluronic Acid Dermal Filler
Status: COMPLETED
Conditions: Hyaluronic Acid|Dermal Fillers
Interventions: DEVICE: Formaderm Young|DEVICE: Restylane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of ADXS31-164 in Subjects With HER2 Expressing Solid Tumors
Status: COMPLETED
Conditions: HER2 Expressing Solid Tumors
Interventions: DRUG: ADXS31-164
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Proximal Femoral Nail Antirotation for the Treatment of Intertrochanteric Femoral Fracture
Status: UNKNOWN
Conditions: Intertrochanteric Femoral Fracture
Interventions: DEVICE: proximal femoral nail antirotation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Scoring Balloon and Conventional Balloon Predilation Before Drug Coated Balloon for de Novo Lesion in Patients With High Bleeding Risk
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: NSE balloon|DEVICE: NC balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Effectiveness of 2 Lower Dose Combined PDE5i's Versus Single Maximal Dose PDE5i Treatment
Status: UNKNOWN
Conditions: Erectile Dysfunction
Interventions: DRUG: Sildenafil 100 mg|DRUG: Tadalafil 20 mg|DRUG: Combination half of maximal dose for sildenafil & tadalafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Vocational Rehabilitation on Mentally III Veterans
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder (PTSD)
Interventions: BEHAVIORAL: Vocational Rehabilitation Program (VRP)|BEHAVIORAL: Individual Placement and Support (IPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polymorphism of Janus Kinase 1 and 2 (JAK 1&2) in Patients With Alopecia Areata
Status: RECRUITING
Conditions: Alopecia Areata
Interventions: GENETIC: Janus Kinase 1 and 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Neurochemical Effects of Omega-3 Fatty Acids in Adolescents at Risk for Mania
Status: COMPLETED
Conditions: Mania
Interventions: DRUG: OMega 3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Multicenter, Phase-II Trial of Ibrutinib Plus Venetoclax in Patients With Creatinine Clearance >= 30 ml/Min Who Have Relapsed or Refractory Chronic Lymphocytic Leukemia (RR-CLL) With or Without TP53 Aberrations
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia in Relapse|Chronic Lymphocytic Leukemia in Remission
Interventions: DRUG: Ibrutinib + Venetoclax 15 cycles|DRUG: Ibrutinib until progression/relapse|DRUG: Possible reinitiation treatment: Ibrutinib + Venetoclax 12 cycles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Switching From Efavirenz/Atripla to Rilpivirine Among Patients With Neurocognitive or Neuropsychological Side Effects
Status: COMPLETED
Conditions: Impaired Cognition|Depression/Anxiety|Poor Quality Sleep|Quality of Life|HIV-1 Infection
Interventions: DRUG: Immediate switch to TDF/FTC/RPV|DRUG: Switch to TDF/FTC/RPV after 24 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spinal Cord Stimulation to Augment Activity Based Therapy
Status: COMPLETED
Conditions: Transcutaneous Spinal Stimulation|Walking|Spasticity|Human|Spinal Cord Injuries
Interventions: DEVICE: Transcutaneous spinal stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Testing a Home-Based Rehabilitation Intervention Designed to Improve Outcomes of Frail Veterans Following Cardiothoracic Surgery
Status: COMPLETED
Conditions: Coronary Artery Bypass Graft|Non-cardiac Thoracic Surgery|Frailty
Interventions: OTHER: Prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy of KY1044 and Atezolizumab in Advanced Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Squamous Cell Carcinoma of Head and Neck|Non-small Cell Lung Cancer|Hepatocellular Carcinoma|Esophageal Cancer|Gastric Cancer|Melanoma|Renal Cell Carcinoma|Pancreatic Cancer|Cervical Cancer|Triple Negative Breast Cancer|Advanced Cancer|Metastatic Cancer
Interventions: DRUG: KY1044|DRUG: KY1044 and atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TBNA vs EBUS-TBNA Plus Transbronchial Mediastinal Cryobiopsy for Adequacy of Next Generation Sequencing
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer
Interventions: PROCEDURE: Endobronchial ultrasound with transbronchial needle aspiration|PROCEDURE: Bronchoscopy|PROCEDURE: Cryobiopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Computer-Delivered Intervention for Individuals With Obesity and Elevated Anxiety Sensitivity
Status: COMPLETED
Conditions: Obesity|Anxiety Sensitivity|Eating|Physical Activity
Interventions: OTHER: Anxiety Sensitivity Training|OTHER: Health Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Comparison of Long-Term Healing Between Biodegradable- Versus Durable-Polymer Everolimus Eluting Stents in STEMI
Status: UNKNOWN
Conditions: STEMI - ST Elevation Myocardial Infarction
Interventions: DEVICE: Synergy|DEVICE: Xience
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fulvestrant With or Without Bortezomib in Patients With Inoperable Locally Advanced or Metastatic Estrogen Receptor Positive Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Carcinoma|Stage IIIB Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7|Stage IV Breast Cancer AJCC v6 and v7
Interventions: DRUG: Bortezomib|DRUG: Fulvestrant|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Real-time Diagnosis of Serum LECT 2 in Patient With Liver Cancer Using Electronic Antibody Sensor (e- Ab Sensor)
Status: UNKNOWN
Conditions: Liver Cancer
Interventions: DEVICE: Electrosensing antibody probing system (e- Ab sensor)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: NAB-PACLITAXEL Plus FOLFOX as Perioperative Chemotherapy in Patients With Operable Oesogastric Adenocarcinoma
Status: UNKNOWN
Conditions: Cancer of Stomach
Interventions: DRUG: nab-paclitaxel|DRUG: FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduction of Conscious Sedation Requirements by Olfactory Stimulation
Status: COMPLETED
Conditions: Colon Cancer Screening|Colon Polyps
Interventions: PROCEDURE: Aroma therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nebulised Hypertonic Saline to Decrease Respiratory Exacerbations in Neuromuscular Disease or Neurodisability
Status: NOT_YET_RECRUITING
Conditions: Neuromuscular Diseases|Neurodevelopmental Disorders|Cerebral Palsy
Interventions: DEVICE: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Tucatinib (ONT-380) Combined With Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2+ Breast Cancer
Status: COMPLETED
Conditions: HER2 Positive Breast Cancers
Interventions: DRUG: Tucatinib (ONT-380)|DRUG: T-DM1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of AZD6244 in Combination With Capecitabine and Radiotherapy in Locally Advanced Adenocarcinoma of the Rectum
Status: TERMINATED
Conditions: Non-Metastatic Adenocarcinoma of the Rectum
Interventions: PROCEDURE: Radiation Therapy|DRUG: Capecitabine|DRUG: AZD6244
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Induction Strategies Combined With Low Tacrolimus Exposure in Kidney Transplant Recipients Receiving Everolimus or Sodium Mycophenolate
Status: COMPLETED
Conditions: Cytomegalovirus Infection|Renal Transplant Failure|Transplant; Complication, Rejection
Interventions: DRUG: Thymoglobulin|DRUG: Everolimus|DRUG: Basiliximabe|DRUG: mycophenolate sodium|DRUG: Tacrolimus|DRUG: Tacrolimus|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Niraparib Plus Carboplatin in Patients With Homologous Recombination Deficient Advanced Solid Tumor Malignancies
Status: TERMINATED
Conditions: Solid Tumor, Adult|Homologous Recombination Deficiency
Interventions: DRUG: Niraparib|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Comparison of Two Multifocal Toric Soft Contact Lenses
Status: ACTIVE_NOT_RECRUITING
Conditions: Astigmatism|Presbyopia
Interventions: DEVICE: Lens A (omafilcon A)|DEVICE: Lens B (comfilcon A)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Puncture Template Assisted Biopsy for Pulmonary Nodules
Status: RECRUITING
Conditions: Pulmonary Nodule|CT Guided Biopsy
Interventions: BEHAVIORAL: CT guided biopsy for pulmonary nodule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cesarean Scar Defect Formation After First Cesarean Section.
Status: UNKNOWN
Conditions: Cesarean Section Complications|Cesarean Wound Disruption|Cesarean Wound; Dehiscence
Interventions: OTHER: Transvaginal sonography at six months after cesarean section|OTHER: Transvaginal sonography at twelve months after cesarean section
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Efficacy of a Coordinated Interprofessional Care Pathway on Disability in Patients With Chronic and at Risk of Chronic Low Back Pain in Primary Care
Status: RECRUITING
Conditions: Low Back Pain
Interventions: PROCEDURE: collaboration general practitioner and physiotherapist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Lipid Lowering Agents on Diabetic Retinopathy and Cardiovascular Risk of Diabetic Patients
Status: UNKNOWN
Conditions: Diabetic Retinopathy
Interventions: DRUG: Simvastatin 40mg|DRUG: Fenofibrate 200mg|DRUG: Omega 3 fatty acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sintilimab With or Without Radiotherapy in Patients With Recurrent or IV NSCLC (EGFR -, ALK -) After Failure of Platinum-based Chemotherapy: A Randomized,Open Labled, Phase II Clinical Study
Status: UNKNOWN
Conditions: Lung Neoplasms
Interventions: DRUG: Sintilimab|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of the Preparation Method of Red Cell Concentrates on Transfusion Indices in Thalassemic Patients
Status: COMPLETED
Conditions: Thalassemia Major
Interventions: BIOLOGICAL: Blood component A|BIOLOGICAL: Blood component B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromodulation Techniques in the Treatment of Chronic Tinnitus With Hearing Loss
Status: COMPLETED
Conditions: Tinnitus|Hearing Loss
Interventions: PROCEDURE: Transcranial Magnetic Stimulation|PROCEDURE: Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ALTA-1L Study: A Study of Brigatinib Versus Crizotinib in Anaplastic Lymphoma Kinase Positive (ALK+) Advanced Non-small Cell Lung Cancer (NSCLC) Participants
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer|Lung Cancer|Advanced Malignancies|Carcinoma
Interventions: DRUG: Brigatinib|DRUG: Crizotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Itacitinib, Tacrolimus, and Sirolimus for the Prevention of GVHD in Patients With Acute Leukemia, Myelodysplastic Syndrome, or Myelofibrosis Undergoing Reduced Intensity Conditioning Donor Stem Cell Transplantation
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Leukemia|Hematologic and Lymphocytic Disorder|Myelodysplastic Syndrome|Primary Myelofibrosis|Secondary Myelofibrosis
Interventions: DRUG: Fludarabine|DRUG: Itacitinib Adipate|DRUG: Melphalan|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|DRUG: Sirolimus|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab-pvvr and Abatacept vs Rituximab-pvvr Alone in New Onset Type 1 Diabetes
Status: RECRUITING
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Rituximab-pvvr|DRUG: Abatacept|DRUG: Sterile Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Diazepam in the Management of Refractory Epilepsy in Selected Patients Who Require Intermittent Medical Intervention for Acute Repetitive Seizures.
Status: COMPLETED
Conditions: Seizures|Epilepsies, Partial|Epilepsy, Complex Partial|Epilepsy, Generalized|Epilepsy
Interventions: DRUG: Placebo|DRUG: Vanquix Auto-Injector (Diazepam Injection)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Intensive Long-Term Vasodilation in Hypertensive Patients With Microvascular Angina Pectoris
Status: TERMINATED
Conditions: Microvascular Angina|Hypertension
Interventions: DRUG: Lercanidipine|DRUG: Valsartan|DRUG: Nicorandil|DRUG: Doxazosin|DRUG: Moxonidin|DRUG: Pindolol|DRUG: Amiloride, hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-Clofarabine PET/CT in Imaging Cancer Patients Before and After Interventions
Status: TERMINATED
Conditions: Malignant Neoplasm
Interventions: PROCEDURE: Computed Tomography|RADIATION: Fluorine F 18 Clofarabine|PROCEDURE: Positron Emission Tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of MBI for Depressive Symptoms in Patients With MS
Status: COMPLETED
Conditions: Multiple Sclerosis|Depression
Interventions: BEHAVIORAL: Mindfulness|BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Oxygen Therapy Improves Brain Function in Patients With Cognitive Decline After COVID-19 Infection.
Status: NOT_YET_RECRUITING
Conditions: Cognitive Decline|COVID-19|SARS CoV 2 Infection
Interventions: PROCEDURE: hyperbaric oxygen therapy|PROCEDURE: conventional oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Different Doses of BI 1358894 and Find Out Whether They Reduce Symptoms in People With Borderline Personality Disorder
Status: COMPLETED
Conditions: Borderline Personality Disorder
Interventions: DRUG: BI 1358894|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PROgressive struCturEd Simulation-based Surgical Training Program (PROCESS) - Open Vascular Surgery
Status: NOT_YET_RECRUITING
Conditions: Vascular Diseases|Competency-Based Education|Simulation Training
Interventions: OTHER: Progression and structured surgical training.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of Dental Anxiety in Second-Stage Implant Surgery With Er,Cr:YSGG Laser
Status: COMPLETED
Conditions: Dental Anxiety
Interventions: PROCEDURE: Scalpel|DEVICE: 2780 nm Er,Cr:YSGG Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study on BI 54903 (Inhaled Corticosteroid) Administered Twice Daily Via Respimat Inhaler in Patients With Asthma Inadequately Controlled on Low Dose Inhaled Corticosteroid (ICS)
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: Placebo|DRUG: BI 54903|DRUG: Fluticasone propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Health-Related Outcomes in Patients Who Were Previously Treated for Rhabdomyosarcoma
Status: COMPLETED
Conditions: Long-term Effects Secondary to Cancer Therapy in Children|Sarcoma
Interventions: PROCEDURE: management of therapy complications|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vaccine Therapy in Treating Patients With Malignant Glioma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: BIOLOGICAL: glioma-associated antigen peptide-pulsed autologous dendritic cell vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Symptomatic Relief of Acute Dyspeptic Pain in Emergency Department With Pantoprazole
Status: COMPLETED
Conditions: Dyspepsia|Emergency|Pain
Interventions: DRUG: Normal saline|DRUG: Pantoprazole|DRUG: Oral antacid|DRUG: Hyoscine butylbromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarkers in Aortic Stenosis - B.A.S.S.
Status: COMPLETED
Conditions: Aortic Stenosis|Disorder of Prosthetic Cardiac Valve|Aortic Valve Insufficiency|Mitral Valve Insufficiency|Hypertrophic Cardiomyopathy|Tricuspid Valve Insufficiency
Interventions: PROCEDURE: Blood Draw
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Acetazolamide on Lung Water Content by Ultrasound in Patients With Respiratory Disease at Altitude
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: ACETAZOLAMIDE oral capsule|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, and Efficacy of GLS-012 and GLS-010 in Patients With Advanced Non-Small Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Advanced Non-Small Cell Lung Cancer
Interventions: DRUG: GLS-012+GLS-010|DRUG: GLS-012+GLS-010|DRUG: GLS-012+GLS-010+pemetrexed+carboplatin|DRUG: GLS-012+GLS-010+paclitaxel+carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ciclosporin A Preconditioning for Renal Artery Stenosis
Status: COMPLETED
Conditions: Renal Artery Stenosis
Interventions: DRUG: Ciclosporin A preconditioning before renal artery stenosis dilation|DRUG: NaCl preconditioning before renal artery stenosis dilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of a BTK Inhibitor in Subjects With Relapsed or Refractory Diffuse Large B-cell Lymphoma
Status: COMPLETED
Conditions: Diffuse Large Cell B-lymphoma
Interventions: DRUG: ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Collection of Real-life Measurement Data for TENA SmartCare Change Indicator in Subjects With Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: DEVICE: TENA SmartCare Change Indicator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Laser Ablation of Papillary Thyroid Microcarcinoma
Status: RECRUITING
Conditions: Papillary Thyroid Microcarcinoma|Thyroid|Thyroid Cancer
Interventions: PROCEDURE: Percutaneous Laser Ablation (PLA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flemish Joint Effort for Biomarker pRofiling in Inflammatory Systemic Diseases
Status: RECRUITING
Conditions: Autoinflammatory Disease|Autoimmune Diseases|Inflammation
Interventions: DIAGNOSTIC_TEST: cytokine and lipidomic profiling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Group Cognitive Behavioral Therapy and Acupressure for Insomnia
Status: COMPLETED
Conditions: Insomnia
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia|OTHER: Acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of ALA on Retrolingual Collapse in Patients With Multilevel Obstructive OSA
Status: NOT_YET_RECRUITING
Conditions: Obstructive Sleep Apnea
Interventions: PROCEDURE: Anterolateral advancement pharyngoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Immunity Persistence Study of Live Attenuated Varicella Vaccine
Status: ENROLLING_BY_INVITATION
Conditions: Varicella
Interventions: BIOLOGICAL: Investigational Live Attenuated Varicella Vaccine|BIOLOGICAL: Placebo (Freeze Dired Dilution)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Eltrombopag Olamine in Improving Platelet Recovery in Older Patients With Acute Myeloid Leukemia Undergoing Chemotherapy
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome|Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Secondary Acute Myeloid Leukemia
Interventions: DRUG: eltrombopag olamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Efficacy of Probiotic Compared With Placebo Commitment Therapy for Treatment of Major Depressive Disorder
Status: WITHDRAWN
Conditions: Major Depressive Disorder
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo|BEHAVIORAL: Acceptance and commitment therapy (ACT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PMCF Study on Monofocal Toric IOL (PODEYE TORIC) in Asia
Status: COMPLETED
Conditions: Cataract|Lens Opacities|Astigmatism
Interventions: DEVICE: IOL implantation experimental
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anlotinib, Toripalimab and Nab-paclitaxel in Locally Advanced/Metastatic Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Neoplasm|Metastatic Pancreatic Cancer|Locally Advanced Pancreatic Adenocarcinoma
Interventions: DRUG: Anlotinib+Toripalimab+Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Thrust Manipulation of Sacroiliac Joint and Pelvic Stabilization Exercises in Post Partum Low Back Pain
Status: RECRUITING
Conditions: Low Back Pain, Post Partum
Interventions: OTHER: SI joint thrust manipulation|OTHER: pelvic stabilization exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Maintenance Hormonal Therapy and DLBCL
Status: NOT_YET_RECRUITING
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: Tamoxifen 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Fetoplacental Oxygenation With Functional MRI in Pregnant Women
Status: COMPLETED
Conditions: Intrauterine Growth Restriction
Interventions: OTHER: Bold sequence patients test|OTHER: Bold + ASL sequence
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Niclosamide With Etanercept in Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis (RA)
Interventions: DRUG: Placebo|DRUG: Niclosamide|DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Taurine in Adolescents With Bipolar Disorder
Status: TERMINATED
Conditions: Bipolar Disorder
Interventions: DRUG: Taurine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Left Ventricular Lead To Improve Cardiac Output
Status: COMPLETED
Conditions: Ischemic Congestive Cardiomyopathy|Dilated Cardiomyopathy|Congestive Heart Failure
Interventions: PROCEDURE: Doppler flow measurement|PROCEDURE: standard implantation of the LV lead
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Antiplaque Effect of Essential Oils With and Without Alcochol on an in Situ Model of Oral Biofilm Growth
Status: UNKNOWN
Conditions: Biofilms|Oils, Essential|Periodontitis
Interventions: DRUG: Essential oils|DRUG: Essential oils without alcohol|DRUG: Sterile water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MEK Inhibitor MEK162, Idarubicin, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Recurrent Adult Acute Myeloid Leukemia
Interventions: DRUG: MEK inhibitor MEK162|DRUG: idarubicin|DRUG: cytarabine|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anthrax AV7909 Liquid vs Lyophilized
Status: COMPLETED
Conditions: Anthrax|Anthrax Immunisation
Interventions: BIOLOGICAL: AV7909|BIOLOGICAL: AV7909
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Extra - Abdominal Versus Intra - Abdominal Repair of the Uterine Incision at Cesarean Section
Status: COMPLETED
Conditions: Cesarean Wound Repair
Interventions: PROCEDURE: Intra-abdominal repair|PROCEDURE: Extra-abdominal repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Contraceptive Efficacy of an Intravaginal Ring With LNG (Levonorgestrel) Over One Year in Healthy Women
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Levonorgestrel (BAY98-7196)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Imiquimod Versus Photodynamic Therapy of Actinic Keratoses in Organ Transplant Recipients
Status: TERMINATED
Conditions: Actinic Keratoses
Interventions: OTHER: photodynamic therapy|DRUG: imiquimod 5% cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Pharmacokinetics and Safety of Tocilizumab (RoActemra/Actemra) in Participants Less Than 2 Years Old With Active Systemic Juvenile Idiopathic Arthritis (sJIA)
Status: COMPLETED
Conditions: Juvenile Idiopathic Arthritis
Interventions: DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib and Dexamethasone in Treating Patients With Multiple Myeloma That Has Relapsed or Has Not Responded to Treatment
Status: UNKNOWN
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: bortezomib|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Bronchodilator Efficacy of Formoterol/Budesonide 12/400 mcg Via Discair in COPD
Status: COMPLETED
Conditions: Copd
Interventions: DRUG: Formoterol/Budesonide 12/400 mcg Discair
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apnex Clinical Study of the Hypoglossal Nerve Stimulation (HGNS®) System to Treat Obstructive Sleep Apnea
Status: TERMINATED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Hypoglossal Nerve Stimulation (HGNS) System (Apnex Medical )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Scheduled Intravesical Gemcitabine Versus Intravesical BCG for Intermediate and High Risk Non Muscle Invasive Bladder Cancer: A Prospective, Randomized Study
Status: RECRUITING
Conditions: Non-muscle-invasive Bladder Cancer
Interventions: DRUG: BCG|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clopidogrel Response Evaluation and AnTi-Platelet InterVEntion in High Thrombotic Risk PCI Patients
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DRUG: Clopidogrel 75mg|DRUG: Clopidogrel 150mg|DRUG: Aspirin 100mg|DRUG: Cilostazol 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Analgesic Effect of Subcostal TAPB for Laparoscopic Gastrectomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Ultrasound guided subcostal transversus abdominis plane block (TAPB)|DRUG: Ropivacaine 0.75% Injectable Solution|DEVICE: 21G 100 mm stimulator needle (Echoplex®, Vygon, Ecouen, France)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test How Well Empagliflozin Works in Chinese Patients With Type 2 Diabetes Who Already Take Insulin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Empagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Neratinib Versus Lapatinib Plus Capecitabine For ErbB2 Positive Advanced Breast Cancer
Status: COMPLETED
Conditions: Advanced Breast Cancer|Breast Cancer
Interventions: DRUG: Neratinib|DRUG: Lapatinib|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comprehensive vs. Assisted Management of Mood and Pain Symptoms
Status: COMPLETED
Conditions: Pain|Depression|Anxiety|Musculoskeletal|Fibromyalgia
Interventions: OTHER: Assisted Symptom Management (ASM)|OTHER: Comprehensive Symptom Management (CSM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Biofeedback-Assisted Relaxation Training in Children With Eosinophilic Duodenitis
Status: COMPLETED
Conditions: Abdominal Pain|Duodenitis
Interventions: BEHAVIORAL: Biofeedback-assisted relaxation training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Irritation Potential of GSK1940029 Gel
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: 0.3% GSK1940029 gel|DRUG: 1% GSK1940029 gel|DRUG: 0.3%/1% vehicle gel only|OTHER: Sterile distilled water|OTHER: 0.5% SLS in sterile distilled water|OTHER: 0.1% SLS in sterile distilled water|OTHER: Patch only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Concomitant Longitudinal Evaluation of Adalimumab With Methotrexate in the Real World: the CLEAR Study
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Adalimumab|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Ascorbic Acid in Patients Treating With Recurrent High Grade Glioma
Status: TERMINATED
Conditions: Glioblastoma|Glioma
Interventions: DIETARY_SUPPLEMENT: Ascorbic Acid|BIOLOGICAL: Bevacizumab|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Treatment of Shoulder Pain in Hemiplegic Spastic Patients With Botulinum Toxin A
Status: COMPLETED
Conditions: Shoulder Pain
Interventions: DRUG: AbobotulinumtoxinA|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Accuracy Between Cuffless Wrist Worn and Cuffed Ambulatory BP Monitoring Devices
Status: NOT_YET_RECRUITING
Conditions: Blood Pressure
Interventions: DEVICE: Aktiia Bracelet|DEVICE: Healthstats BPro Evo|DEVICE: Spacelabs OnTrak Ambulatory Blood Pressure monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study on PhArmacokinetics of First liNe Antiretrovirals in Healthy Breastfeeding Volunteers
Status: RECRUITING
Conditions: Hiv
Interventions: DRUG: Doravirine 100Mg Tab|DRUG: Raltegravir 600Mg Tab|DRUG: Biktarvy 50/200/25 Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Bemarituzumab (FPA144) Combined With Modified FOLFOX6 in Gastric/Gastroesophageal Cancer
Status: COMPLETED
Conditions: Gastrointestinal Cancer|Gastrointestinal Cancer Metastatic|Gastric Cancer
Interventions: BIOLOGICAL: Bemarituzumab|DRUG: Modified FOLFOX6
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-Intensity Focused Ultrasound on Individuals With Disorder of Consciousness of Traumatic Brain Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury With Prolonged Loss of Consciousness
Interventions: DEVICE: Low-Intensity Focused Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Granule and Tablet Formulations of Deferitazole (Disodium Salt) and a Capsule Formulation of Deferitazole (Magnesium Hydroxide Salt)
Status: WITHDRAWN
Conditions: Healthy
Interventions: DRUG: Deferitazole (disodium salt, granule)|DRUG: Deferitazole (disodium salt, tablet)|DRUG: Deferitazole (magnesium hydroxide salt)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase 1 Dose Escalating Study to Assess Safety, Tolerability, Food Effect and PK of CHR-5154 in Healthy Male Volunteers
Status: TERMINATED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: CHR-5154|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Specialized Therapeutic Care of Patients Presenting an Intolerance Attributed to Electromagnetic Fields
Status: COMPLETED
Conditions: Idiopathic Environmental Intolerance Attributed to Electromagnetic Fields
Interventions: OTHER: Individual medical Care|OTHER: Individual electromagnetic exposures
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Trial of Verubecestat (MK-8931) in Participants With Prodromal Alzheimer's Disease (MK-8931-019)
Status: TERMINATED
Conditions: Amnestic Mild Cognitive Impairment|Alzheimer's Disease|Prodromal Alzheimer's Disease
Interventions: DRUG: Verubecestat 12 mg (Parts 1 and 2)|DRUG: Verubecestat 40 mg (Parts 1 and 2)|OTHER: Placebo (Part 1)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Effect of Facial Serum Q69 in Moderating the Appearance of Mild to Moderate Melasma
Status: COMPLETED
Conditions: Melasma
Interventions: OTHER: Cosmetic facial serum Q69|DRUG: 2% Hydroquinone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: InductionChemo-Radio-Antibody-Treatment
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head|Squamous Cell Carcinoma of the Neck
Interventions: DRUG: TPF induction chemotherapy|DRUG: TPF experimental|RADIATION: Standard Radiochemotherapy (HART)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Efficacy of Doxorubicin and Pembrolizumab for Sarcoma
Status: COMPLETED
Conditions: Soft Tissue Sarcoma, Adult|Soft Tissue Sarcoma, Child
Interventions: DRUG: Pembrolizumab|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT