pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Effect of Chronic Care Model Based Education on Disease Management in Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: control by dietitian|OTHER: Exercise programs|BEHAVIORAL: control by psychiatrist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Utility and Feasibility of Mt-sDNA as a Surveillance Procedure in Colorectal Cancer Survivors
Status: RECRUITING
Conditions: Adenocarcinoma of the Colon|Adenocarcinoma of the Rectum|Stage I Colorectal Cancer|Stage II Colorectal Cancer|Stage III Colorectal Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Holmium Laser Enucleation Prostatectomy and Open Transvesical Prostatectomy in Large Prostate
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: PROCEDURE: Holep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Submucosal Injection of Indocyanine Green Before Laparoscopic Gastrectomy
Status: UNKNOWN
Conditions: Endoscopic Submucosal Injection of Indocyanine Green
Interventions: PROCEDURE: endoscopic submucosal injection of indocyanine green before laparoscopic gastrectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Safety and Efficacy of Using Seraffix LTB - (Laser Tissue Bonding) System
Status: COMPLETED
Conditions: Dehiscence, Surgical Wound
Interventions: DEVICE: Seraffix LTB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Antitumor Activity, Safety, Tolerability, and Pharmacokinetics of BGB-A445 in Combination With Tislelizumab in Participants With Select Advanced Solid Tumors.
Status: RECRUITING
Conditions: Urothelial Carcinoma|Renal Cell Carcinoma|Melanoma|Non-mucosal Melanoma
Interventions: DRUG: BGB-A445|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PD-1 Inhibitor Combined With Progesterone Treatment in FST for Patients With MMRd Endometrial Cancer
Status: NOT_YET_RECRUITING
Conditions: Endometrial Cancer|Endometrioid Carcinoma|Mismatch Repair Deficiency
Interventions: DRUG: Sintilimab or Pembrolizumab and medroxyprogesterone acetate (MPA)/ megestrol acetate (MA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigation Into the Cardiovascular Risk and Aetiology of CKDu in Sri Lanka
Status: COMPLETED
Conditions: CKDu|Arterial Stiffness|Proteinuria|Serum Creatinine|Urinary Biomarkers|DNA Adducts
Interventions: DEVICE: Arterial Stiffness Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Absorption, Metabolism, Excretion and Pharmacokinetics of a Single Dose [14C]AZD2014 Followed by a Multiple Dose Phase
Status: COMPLETED
Conditions: Solid Malignancies
Interventions: DRUG: [14C]AZD2014|DRUG: Multiple dose AZD2014|DRUG: Fulvestrant|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of PF-04217329 in Patients With Glaucoma or Elevated Eye Pressure.
Status: COMPLETED
Conditions: Primary Open-Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: PF-04217329 - Lowest Dose|DRUG: PF-04217329 - Low Dose|DRUG: PF-04217329 - Middle Dose|DRUG: PF-04217329 - High Middle Dose|DRUG: PF-04217329 - High Dose|DRUG: PF-4217329 - Highest Dose|DRUG: PF-04217329 - Vehicle|DRUG: Latanoprost Vehicle|DRUG: PF-04217329 - Low Dose|DRUG: Latanoprost Vehicle|DRUG: PF-04217329 - Middle Dose|DRUG: Latanoprost Vehicle|DRUG: PF-04217329 - High Dose|DRUG: Latanoprost 0.005%|DRUG: PF-04217329 - Low Dose|DRUG: Latanoprost 0.005%|DRUG: PF-04217329 - Middle Dose|DRUG: Latanoprost 0.005%|DRUG: PF-04217329 - High Dose|DRUG: Latanoprost 0.005%|DRUG: PF-04217329 - Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Impact of Adaptive Goal Setting on Engagement Levels of Government Staff With a Gamified mHealth Tool
Status: COMPLETED
Conditions: Lifestyle|Lifestyle, Healthy|Lifestyle, Sedentary|Lifestyle Risk Reduction
Interventions: BEHAVIORAL: GameBus (mHealth app)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation in Monotherapy (GETGOAL-MONO Japan LTS)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Lixisenatide (AVE0010)|DEVICE: Pen auto-injector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Cipros 20 Association on Dyslipidemia Treatment
Status: RECRUITING
Conditions: Dyslipidemias
Interventions: DRUG: Cipros 20 association|DRUG: Crestor 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Carboxymethylcellulose Artificial Tears on the Eye Microbiome
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: Carboxymethylcellulose (CMC) Artificial Tears|DRUG: Preservative-free, CMC-free Artificial Tears (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Blood Loss in Using vs Not Using Placental Cord Drainage After Spontaneous Vaginal Delivery
Status: UNKNOWN
Conditions: Placental Blood Drainage
Interventions: PROCEDURE: Placental Blood Drainage|PROCEDURE: not Placental Blood Drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Mirtazapine or Dexamethasone for Post-spinal Anesthesia Shivering
Status: COMPLETED
Conditions: Shivering
Interventions: DRUG: Mirtazapine|DRUG: Dexamethasone phosphate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Cognitive Behavioral Therapy for Insomnia in Substance Use Disorders
Status: COMPLETED
Conditions: Substance Use Disorders|Insomnia
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia (CBT-I)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Structural and Metabolic Determinants of Sarcopenia and the Efficacy of Concentric vs. Eccentric Exercise Training
Status: COMPLETED
Conditions: Healthy
Interventions: BEHAVIORAL: Concentric Exercise Training|BEHAVIORAL: Eccentric Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy Study of a Bioelectric Dressing to Treat Wounds Caused by Curettage and Electrodesiccation
Status: COMPLETED
Conditions: Wound Healing|Wound Infection
Interventions: DEVICE: Procellera™ Antimicrobial Wound Dressing|DRUG: ACTICOAT™ Antimicrobial Barrier Dressing|DRUG: Mepilex® Ag Silver Foam Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 8- Versus 12-week of Sofosbuvir-ravidasvir Treatment of Chronic Hepatitis C
Status: UNKNOWN
Conditions: Hepatitis C
Interventions: DRUG: Sofosbuvir 400 MG|DRUG: Ravidasvir 200mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Controlled Release Nifedipine and Valsartan Combination Therapy in Patients With Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Nifedipine (Adalat, BAYA1040)|DRUG: Amlodipine (Norvasc)|DRUG: Diovan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Application of Balanced Propofol Sedation in Fiberoptic Bronchoscopy
Status: COMPLETED
Conditions: Bronchoscopy
Interventions: DRUG: Midazolam and sufentanil|DRUG: Midazolam, sufentanil and propofol|DRUG: Remazolam and sufentanil.|DRUG: Remazolam, sufentanil and propofol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate a Therapeutic Vaccine, ASP0113, in Cytomegalovirus (CMV)-Seropositive Recipients Undergoing Allogeneic, Hematopoietic Cell Transplant (HCT)
Status: COMPLETED
Conditions: Cytomegalovirus (CMV)-Positive Recipients|Allogeneic, Hematopoietic Cell Transplant (HCT)
Interventions: BIOLOGICAL: ASP0113|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: High-Density Lipoprotein (HDL) Treatment Study
Status: COMPLETED
Conditions: Coronary Arteriosclerosis|Hypoalphalipoproteinemias|Genetic Diseases, Inborn
Interventions: DRUG: Atorvastatin; Fenofibrate; Niacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fertility After Myomectomy Versus Uterine Artery Embolization for Symptomatic Uterine Fibroids
Status: COMPLETED
Conditions: Leiomyoma
Interventions: PROCEDURE: myomectomy|PROCEDURE: embolisation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Two Needle Insertion Techniques on Success Rate and Complications During Central Venous Catheterization
Status: COMPLETED
Conditions: Complications of Central Venous Catheterization
Interventions: PROCEDURE: modified Seldinger technique|PROCEDURE: Seldinger technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Fasting Therapy on Blood Glucose Control and Islet Function in Newly Diagnosed Type 2 Diabetic Patients
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: Fasting therapy|DRUG: Insulin intensive therapy: Human Insulin (Novolin-R, Novo Nordisk)|OTHER: Exercise|BEHAVIORAL: Lifestyle guidance|DEVICE: H-Tron Plus V100; Disetronic Medical System, Burgdorf, Switzerland
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Single-Center, Open-Label, Randomized, 3-Treatment Crossover Bioavailability Study of Single Oral Doses of E5501 Old Tablet Formulation Under Fasted Conditions and a New Tablet Formulation Under Fed and Fasted Conditions in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: E5501|DRUG: E5501|DRUG: E5501
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of the GM-CSF Gel on the Endometrial Thickness in Infertile Women With Thin Endometrium
Status: UNKNOWN
Conditions: Thin Endometrium
Interventions: DRUG: GM-CSF|DRUG: 17-ß estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Rate of Falls in Older People by Means of Vestibular Rehabilitation (ReFOVeRe Study)
Status: UNKNOWN
Conditions: Dizziness Chronic|Fall
Interventions: DEVICE: CDP|DEVICE: Mobile posturography|OTHER: 10 sessions|OTHER: 5 sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An ADME Study of [14C]AZD4604 and the Absolute Bioavailability of AZD4604
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: AZD4604 Inhalation Powder, 1 mg|DRUG: [14C]AZD4604 Solution for Infusion 6 μg/mL (NMT 37.0 kBq/5 mL)|DRUG: [14C]AZD4604 Oral Solution, 4 mg (NMT 37.0 kBq)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contralaterally Controlled FES for Hand Opening in Hemiplegic Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: DEVICE: Contralaterally-controlled functional electrical stimulation|DEVICE: Hand therapy video games
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CMV-MVA Triplex Vac.Enhance Adap. NK Cell Recon. After Auto HSCT in pt Lymphoid Malig
Status: COMPLETED
Conditions: Lymphoma|Multiple Myeloma
Interventions: BIOLOGICAL: CMV-MVA Triplex Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: One-Year Safety and Tolerability Study of Azilsartan Medoxomil in Participants With Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Azilsartan medoxomil with or without add-on chlorthalidone|DRUG: Azilsartan medoxomil with or without add-on hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Fenugreek Use in Mothers of Preterm on Breast Milk Production and Macronutrient Content
Status: UNKNOWN
Conditions: Preterms|Lactation
Interventions: DRUG: Fenugreek seed meal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Malignant Pleural Effusions: Evaluating the psYchosocial Impact of Indwelling Pleural Catheters on Patients
Status: COMPLETED
Conditions: Malignant Pleural Effusion|Indwelling Pleural Catheter
Interventions: OTHER: Semi-structure interviews
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Extracorporeal Shock Wave Therapy in Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: OTHER: Extracorporeal Shock Wave Therapy|OTHER: conventional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MOMENTUM 3 IDE Clinical Study Protocol
Status: COMPLETED
Conditions: Advanced Refractory Left Ventricular Heart Failure
Interventions: DEVICE: HeartMate 3 LVAS|DEVICE: HeartMate II LVAS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of GABA-mediated Inhibition in Multisensory Temporal Processing & Postural Control in Older Adults
Status: NOT_YET_RECRUITING
Conditions: Healthy Aging
Interventions: BEHAVIORAL: Inhibitory control training|BEHAVIORAL: Knowledge-based training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Diabetes-Obstructive Sleep Apnea Treatment Trial
Status: TERMINATED
Conditions: Type 2 Diabetes|Obstructive Sleep Apnea
Interventions: DEVICE: CPAP|DEVICE: Sham-CPAP|BEHAVIORAL: Diabetes Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise Intolerance Study in Long Chain Fatty Acid Oxidation Disorders
Status: RECRUITING
Conditions: Long-chain Fatty Acid Oxidation Disorders
Interventions: OTHER: Intermittent cardiopulmonary exercise test|OTHER: Incremental cardiopulmonary exercise test|OTHER: Echography of upper leg|OTHER: Hand grip strength with hand dynamometer|OTHER: Fill in questionnaires regarding physical activity
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fecal Microbiota Transplantation in Patients With Malignancies Not Responding to Cancer Immunotherapy
Status: RECRUITING
Conditions: Cancer|Fecal Microbiota Transplantation|Immune Checkpoint Inhibitors|Immunotherapy
Interventions: BIOLOGICAL: Fecal Microbiota Transplantation (FMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of FVIIa Variant BAY86-6150 (B0189) in Subjects With Moderate or Severe Hemophilia Types A or B With or Without Inhibitors
Status: COMPLETED
Conditions: Hemophilia A|Hemophilia B
Interventions: DRUG: BAY Factor VII (BAY86-6150)|DRUG: BAY Factor VII (BAY86-6150)|DRUG: BAY Factor VII (BAY86-6150)|DRUG: BAY Factor VII (BAY86-6150)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anesthetic Advantages of Dexmedetomidine for Hypotensive Anesthesia
Status: COMPLETED
Conditions: Anesthesia|Hypotension
Interventions: DRUG: Dexmedetomidine|DRUG: Nitroglycerin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trial to Assess Long-term Lacosamide (LCM) Monotherapy Use and Safety of LCM Monotherapy and Adjunctive Therapy for Partial-onset Seizures
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Lacosamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palbociclib / Letrozole or Fulvestrant in African American Women With HR+ HER2- Breast Cancer
Status: COMPLETED
Conditions: Hormone Receptor Positive HER-2 Negative Breast Cancer
Interventions: DRUG: Palbociclib + Letrozole or Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydralazine and Valproate Added to Chemotherapy for Breast Cancer
Status: TERMINATED
Conditions: Locally Advanced Breast Cancer
Interventions: DRUG: Hydralazine and magnesium valproate administration|PROCEDURE: Core-needle biopsy of the breast
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analysis of the Postprandial Effects of a Vegetable Protein Mixture Rich in Arginine, Cysteine and Leucine on Endothelial Dysfunction and Inflammation at Low Noise in Elderly People With Cardiometabolic Risk
Status: COMPLETED
Conditions: Metabolic Syndrome|Predisposition to Cardiovascular Disease
Interventions: BEHAVIORAL: Vegetable proteins (VP) rich in leucine, cystein, arginine|BEHAVIORAL: Animal proteins (AP)|BEHAVIORAL: No protein (T)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tapinarof for the Treatment of Plaque Psoriasis in Adults (3001)
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Tapinarof|DRUG: Vehicle Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peripheral Mononuclear Cells to Screen, Monitor and Stratify the Population at Risk of Osteoporosis and Fractures
Status: RECRUITING
Conditions: Osteoporosis|Osteopenia|Osteoporosis Fracture
Interventions: DIAGNOSTIC_TEST: Vitality and biological activity of peripheral blood mononuclear cells (PBMCs)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Anti-malaria MAb in Kenyan Children
Status: RECRUITING
Conditions: Plasmodium Falciparum Infection|Malaria
Interventions: DRUG: L9LS|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Erenumab in Chronic Cluster Headache
Status: COMPLETED
Conditions: Cluster Headache|Trigeminal Autonomic Cephalalgias|Headache Disorders, Primary|Brain Disease
Interventions: BIOLOGICAL: Erenumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: ARTEMIS-003: HS-20093 in Patients With Metastatic Castrate-resistant Prostate Cancer (mCRPC) and Advanced Solid Tumors
Status: RECRUITING
Conditions: Metastasis Castration Resistant Prostate Cancer(mCRPC)
Interventions: DRUG: HS-20093
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cetuximab With or Without Tivantinib in Treating Patients With Head and Neck Cancer That Is Recurrent, Metastatic, or Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma|Recurrent Head and Neck Carcinoma
Interventions: BIOLOGICAL: Cetuximab|OTHER: Laboratory Biomarker Analysis|DRUG: Tivantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Effectiveness of 3rd Occipital Radiofrequency Versus Systemic Steroid in Headache Management in Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Headache
Interventions: DRUG: Radiofrequency|DRUG: Steroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyperfractionated RT With BCNU Versus Conventional RT With BCNU for Supratentorial Malignant Glioma
Status: COMPLETED
Conditions: Glioma|Glioblastoma Multiforme|Astrocytoma
Interventions: RADIATION: Conventional RT|RADIATION: Hyperfractionated RT|DRUG: Carmustine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intranasal Ketamine Versus Subcutaneous Ketamine for Treatment of Post-traumatic Acute Pain in the Emergency Department ( INVESCK )
Status: RECRUITING
Conditions: Acute Pain
Interventions: DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3540378 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3540378|DRUG: Placebo|DRUG: LY3540378
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reward Systems and Food Avoidance in Eating Disorders
Status: COMPLETED
Conditions: Low Weight Eating Disorders|Anorexia Nervosa
Interventions: BEHAVIORAL: Interoceptive Exposure (IE)|BEHAVIORAL: Family Based Therapy-Weight Gain Control (FBT-WG)|DIETARY_SUPPLEMENT: meal replacement shake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Repetitive Transcranial Magnetic Stimulation and Robot-Assisted Upper Arm Training in Subacute Stroke Patients
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Armeo and rTMS|DEVICE: Armeo|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Mindfulness on Psychological Well-being of Stroke Survivors and Their Caregivers
Status: COMPLETED
Conditions: Stroke|Stress|Anxiety|Depression
Interventions: BEHAVIORAL: Mindfulness Based Intervention|OTHER: Health Education Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Magnesium in Wheezy Bronchitis
Status: COMPLETED
Conditions: Wheezy Bronchitis
Interventions: DRUG: Magnesium Sulfate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fluid Retention in Rosiglitazone Treated Subjects With Autonomic Neuropathy.
Status: COMPLETED
Conditions: Neuropathy, Diabetic
Interventions: DRUG: rosiglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: T Cell Depletion for Recipients of HLA Haploidentical Related Donor Stem Cell Grafts
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Non Hodgkins Lymphoma|Myelodysplastic Syndrome|Acute Myeloid Leukemia|Chronic Myelogenous Leukemia|Hemophagocytic Lymphohistiocytosis (HLH)|Familial Hemophagocytic Lymphohistiocytosis (FLH)|Viral-associated Hemophagocytic Syndrome (VAHS)|X-linked Lymphoproliferative Disease (XLP)
Interventions: DRUG: Ara-C|DRUG: Cyclophosphamide|BIOLOGICAL: Campath-1H|RADIATION: Total Body Irradiation|PROCEDURE: Stem Cell Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative BAMCOG and Cortisol and Postoperative DeltaScan in AVR Patients (Aortic Valve Replacement)
Status: COMPLETED
Conditions: Delirium|Cognitive Impairment|Cognitive Dysfunction|Cognitive Dysfunction, Postoperative|Delirium in Old Age|Postoperative Delirium
Interventions: DIAGNOSTIC_TEST: MoCA|DEVICE: BAMCOG|DIAGNOSTIC_TEST: DeltaScan|DIAGNOSTIC_TEST: Salivette|DIAGNOSTIC_TEST: Pilocarpine iontophoresis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: UCLA Health Patient Health Maintenance With Interactive Text Reminder
Status: ACTIVE_NOT_RECRUITING
Conditions: Health Maintenance|Diabetes|Cancer
Interventions: BEHAVIORAL: Reminder of preventive care measures|BEHAVIORAL: Acknowledgement of personal responsibility|BEHAVIORAL: Planning prompt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Vedolizumab IV in Pediatric Participants With Ulcerative Colitis (UC) or Crohn's Disease (CD)
Status: COMPLETED
Conditions: Ulcerative Colitis|Crohn's Disease
Interventions: DRUG: Vedolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Usefulness of Exhaled Breath Condensate for Evaluation of Markers of Airway Inflammation in Children With Asthma
Status: UNKNOWN
Conditions: Asthma
Interventions: DRUG: cyklezonid|DRUG: montelukast sodium|DRUG: placebo|DRUG: formoterol 12 mcg twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II, Open-label Study of Ofatumumab Added to Chlorambucil in Previously Untreated Japanese Patients With Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukaemia, Lymphocytic, Chronic
Interventions: DRUG: chlorambucil, tablets|DRUG: ofatumumab (GSK1841157) infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Apixaban vs Warfarin in Reducing Rate of Cognitive Decline, Silent Cerebral Infarcts and Cerebral Microbleeds in Patients With Atrial Fibrillation
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: DRUG: Apixaban|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: MASCOT : Multicenter Asia Study in Adjuvant Treatment of Colon Cancer With OxaliplaTin/5FU-LV
Status: COMPLETED
Conditions: Colonic Neoplasms
Interventions: DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Clarithromycin 250 mg/5 mL Powder for Oral Suspension Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: clarithromycin 250 mg/5 mL powder for oral suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Open Label Comparison of Injectable Buprenorphine ( Brixadi®) and Naltrexone (Vivitrol®) for Opioid Use Disorder
Status: RECRUITING
Conditions: Opioid Use Disorder
Interventions: DRUG: Buprenorphine injection|DRUG: Naltrexone Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zevalin® First Line in Follicular Lymphoma
Status: UNKNOWN
Conditions: Follicular Lymphoma
Interventions: DRUG: 90Yttrium-Ibritumomab Tiuxetan (Zevalin®)+Rituximab|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib and Pegylated Liposomal Doxorubicin Hydrochloride in Treating Patients With Previously Untreated Symptomatic Multiple Myeloma
Status: COMPLETED
Conditions: DS Stage I Plasma Cell Myeloma|DS Stage II Plasma Cell Myeloma|DS Stage III Plasma Cell Myeloma
Interventions: DRUG: Bortezomib|OTHER: Laboratory Biomarker Analysis|DRUG: Pegylated Liposomal Doxorubicin Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Autologous BM-MNC Processed by Two Methods for Treating Patients With Chronic Limb Ischemia
Status: UNKNOWN
Conditions: Critical Limb Ischemia|Peripheral Arterial Disease|Buerger's Disease
Interventions: DEVICE: ResQ processed bone marrow sample|DEVICE: Ficoll conventional cell processing method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of a School- and Primary Care-based Multicomponent Intervention on HPV Vaccination Acceptability
Status: COMPLETED
Conditions: HPV Vaccine Acceptability
Interventions: OTHER: Adolescents and parents' education and motivation at school (component 1)|OTHER: General practitioners' training (component 2)|OTHER: Access to vaccination at school (component 3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Oral LBH589 in Adult Patients With Refractory Cutaneous T-Cell Lymphoma
Status: COMPLETED
Conditions: Cutaneous T-Cell Lymphoma
Interventions: DRUG: Panobinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Bowel Preparation Training Given to Patients Undergoing Colonoscopy
Status: ACTIVE_NOT_RECRUITING
Conditions: Colonoscopy
Interventions: OTHER: Intervention group: nurse-led education for bowel preparation of colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Developing an Online Mindfulness-based Intervention to Reduce Minority Stress and HIV Risk Among Young Adult MSM - Aim 3
Status: RECRUITING
Conditions: Hiv|Minority Stress|Mental Health Wellness 1
Interventions: BEHAVIORAL: Mindfulness-Based Queer Resilience (MBQR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Antiretroviral Therapy for Advanced HIV Disease in South Africa
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Zidovudine|DRUG: Stavudine|DRUG: Didanosine|DRUG: Lamivudine|DRUG: Efavirenz|DRUG: Lopinavir/Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-Line Treatment of Advanced Bladder Cancer Randomized vs. Gemcitabine ± Vinflunine in Patients Ineligible to Receive Cisplatin-Based Therapy
Status: COMPLETED
Conditions: Bladder Cancer|Transitional Cell Carcinoma|Metastasis
Interventions: DRUG: Vinflunine|DRUG: Gemcitabine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Light Cured Resin Modified Calcium Silicate Versus Light Cured Calcium Hydroxide in Indirect Pulp Treatment of Primary Molars
Status: UNKNOWN
Conditions: Deep Carious Lesion|Indirect Pulp Treatment
Interventions: DRUG: Calcium silicate liner|DRUG: Calcium hydroxide liner
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ischemia Detection During Development of Acute Compartment Syndrome
Status: NOT_YET_RECRUITING
Conditions: Ischemia Limb|Blood Circulation Disorder|Carbon Dioxide|Biosensing Techniques|Compartment Syndrome of Leg
Interventions: DEVICE: IscAlert sensor(s) in patient with risk of acute compartment syndrome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Positron-emission Tomography Study to Determine Brain Exposure of [11C]Savolitinib in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: [11C]savolitinib|DRUG: Savolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Study Of Eplerenone In Japanese Patients With Chronic Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Eplerenone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of ORAVESCENT Fentanyl Citrate for the Management of Breakthrough Pain
Status: COMPLETED
Conditions: Chronic Neuropathic Pain
Interventions: DRUG: ORAVESCENT Fentanyl Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Single Center, Randomized, Double-Blind,Crossover Study Comparing Effects Of Single-Dose Fexofenadine HCl 180 mg, Cetirizine 10 mg, and Placebo on Cognitive Performance in Naval Flight Personnel
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: fexofenadine HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Dasatinib in Patients With Isocitrate Dehydrogenase (IDH)-Mutant Advanced Intrahepatic Cholangiocarcinoma
Status: COMPLETED
Conditions: Cholangiocarcinoma
Interventions: DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of OPL-0301 Compared to Placebo in Adults With Post-Myocardial Infarction (MI)
Status: WITHDRAWN
Conditions: Myocardial Infarction
Interventions: DRUG: OPL-0301 Dose 1|DRUG: OPL-0301 Dose 2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: the Effect of Grazoprevir/Elbasvir and TACE vs. TACE Alone in Prolonging Survival of Patients With Non-resectable HCV Associated HCC.
Status: UNKNOWN
Conditions: HCV, HCC
Interventions: DRUG: Grazoprevir/Elbasvir|OTHER: Medical records|PROCEDURE: Transarterial Chemoembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tepotinib With Gefitinib in Participants With Locally Advanced or Metastatic NSCLC (INSIGHT)
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Tepotinib|DRUG: Gefitinib|DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture Using Yamamoto's Method for the Treatment of Acute Nonspecific Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Acupuncture|OTHER: Non-penetrating acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pulsed Electromagnetic Fields for Postoperative Analgesia: A Randomized, Triple-Masked, Sham-Controlled Pilot Study
Status: COMPLETED
Conditions: Postoperative Pain, Acute
Interventions: DEVICE: Active Pulsed Shortwave Treatment with BioElectronics Model 088|DEVICE: Sham Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Bilateral Alveolar Cleft Grafting With Micro Plate Stabilization Versus Conventional Grafting Technique
Status: NOT_YET_RECRUITING
Conditions: Alveolar Cleft
Interventions: PROCEDURE: bilateral alveolar cleft grafting using iliac crest particulate and microplate fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Xenon Inhalation for Treatment of Panic Disorder
Status: UNKNOWN
Conditions: Panic Disorder
Interventions: DRUG: Xenon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Ketamine in Adults With Obsessive-Compulsive Disorder (OCD)
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: DRUG: Ketamine infusion|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Safety Study of Endobronchial Transplantation of Autologous Mesenchymal Stem Cells (MSCs) in Emphysema Patients
Status: UNKNOWN
Conditions: Emphysema
Interventions: BIOLOGICAL: Autologous MSCs transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MLN1117 in Combination With Docetaxel, Paclitaxel, and Other Investigational Anticancer Agents to Treat Participants With Gastric and Gastroesophageal Adenocarcinoma
Status: TERMINATED
Conditions: Advanced and Metastatic Gastric or Gastroesophageal Adenocarcinoma
Interventions: DRUG: MLN1117|DRUG: TAK-659|DRUG: Alisertib|DRUG: Paclitaxel|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of AQW051 in Patients With Memory Impairment
Status: TERMINATED
Conditions: Mild Alzheimer's Disease|Amnestic Mild Cognitive Impairment
Interventions: DRUG: AQW051|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Online Interpersonal Relationships-Based Pyschoeducation in Increasing Sexual Interest and Arousal in Women With Sexual Interest and Arousal Disorder
Status: NOT_YET_RECRUITING
Conditions: Sexual Arousal Disorder|Sexual Desire Disorder
Interventions: BEHAVIORAL: Interpersonal relationship-based intervention program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aldesleukin With or Without Ziv-Aflibercept in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Metastatic Melanoma|Recurrent Melanoma|Stage III Cutaneous Melanoma AJCC v7|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7
Interventions: BIOLOGICAL: Aldesleukin|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Ziv-Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Early Endocapsule (EC) in Clinical Decision Unit Versus Standard of Care Work-up for GI Bleeding
Status: COMPLETED
Conditions: Gastro Intestinal Bleeding|Hematemesis|Melena
Interventions: DEVICE: Video Capsule Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: PROPHYLAXIS OF GVH IN ELDERLY PATIENTS RECEIVING HAPLOIDENTICAL ALLOGENIC HEMATOPOIETIC STEM CELL TRASNPLANTATION USE OF A LOW DOSE ANTI-LYMPHOCYTIC SERUM
Status: NOT_YET_RECRUITING
Conditions: Hematological Malignancy
Interventions: DRUG: Thymoglobulin Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of HDV Insulin Versus Insulin in Type 1 Diabetes Subjects (ISLE-1)
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: HDV Insulin Lispro|DRUG: Insulin LISPRO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Aflibercept Versus Placebo in Patients With Second-Line Docetaxel for Locally Advanced or Metastatic Non-Small-Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma|Non Small Cell Lung
Interventions: DRUG: Aflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®)|DRUG: Placebo|DRUG: Docetaxel (Taxotere®)|DRUG: Dexamethasone (pre- and post-medication for docetaxel)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Maternal Positioning and Occipitoposterior Fetal Position
Status: COMPLETED
Conditions: Maternal Distress in Labor|Persistent Occipitoposterior or Occipitoanterior Position|Dystocia|Fetal Position and Presentation Abnormalities
Interventions: OTHER: Specific maternal position during the labor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Antiviral Activity of Darunavir + Ritonavir in HIV-1 Infected Adolescents
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: darunavir|DRUG: ritonavir|DRUG: zidovudine|DRUG: lamivudine|DRUG: abacavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Futibatinib in Patients Previously Enrolled in an Antecedent Futibatinib as Monotherapy or Combination Therapy.
Status: ENROLLING_BY_INVITATION
Conditions: Advanced/Metastatic Cancer
Interventions: DRUG: futibatinib|DRUG: futibatinib, fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NeoTAILOR: ABiomarker-directed Approach to Guide Neoadjuvant Therapy for Patients With Stage II/III ER-positive, HER2-negative Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Cancer of the Breast
Interventions: DEVICE: VENTANA MIB-1 Ki67 assay|DEVICE: Oncotype DX® Recurrence Score|DEVICE: PAM50-based Prosigna breast cancer gene signature assay|DRUG: Anastrozole|DRUG: Combination anthracycline and/or taxane based treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Assessing the Efficacy and Safety of Alpelisib Plus Fulvestrant or Letrozole, Based on Prior Endocrine Therapy, in Patients With PIK3CA Mutant, HR+, HER2- Advanced Breast Cancer Who Have Progressed on or After Prior Treatments
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Alpelisib|DRUG: Fulvestrant|DRUG: Letrozole|DRUG: Goserelin|DRUG: Leuprolide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety, Tolerability and Efficacy of OMS906 in Paroxysmal Nocturnal Hemoglobinuria
Status: RECRUITING
Conditions: Paroxysmal Nocturnal Hemoglobinuria
Interventions: DRUG: OMS906 study drug
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cocaine, Lidocaine/Xylometazoline and Saline for Nasal Analgesia
Status: RECRUITING
Conditions: Analgesia
Interventions: DRUG: Cociane hydrochloride 4%|DRUG: Lidocaine 4%|DRUG: Xylometazoline 0.1%|DRUG: Saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose Ranging Study of Pazopanib to Treat Neovascular Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DRUG: pazopanib eye drops|DRUG: placebo|BIOLOGICAL: ranibizumab intravitreal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on the Collection of Peripheral Blood Mononuclear Cells From Healthy Volunteers for the Development of Allogeneic Cellular Immunotherapy Products
Status: TERMINATED
Conditions: Collection of Peripheral Blood Mononuclear Cells by Means of Apheresis
Interventions: PROCEDURE: collection of peripheral blood mononuclear cells from healthy volunteers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH