pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Strong Families Start at Home/Familias Fuertes Comienzan en Casa
Status: RECRUITING
Conditions: Metabolic Syndrome, Protection Against|Diet, Healthy
Interventions: BEHAVIORAL: Home-Based Video and Motivational Interviewing Intervention|BEHAVIORAL: Read Educate and Develop Youth (READY) Comparison
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the Bone
Status: RECRUITING
Conditions: Bone Sarcoma|Chondrosarcoma|Chordoma|Ewing Sarcoma of Bone|Pelvic Rhabdomyosarcoma
Interventions: OTHER: Electronic Health Record Review|OTHER: Quality-of-Life Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Foscan®-Mediated Photodynamic Therapy Versus Brachytherapy in Patients With Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: FOSCAN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: JAK2 Mutation May Predict Response and Guide First Line Treatment in Rheumatoid Arthritis
Status: COMPLETED
Conditions: Response Assessment in Newly Diagnosed RA Patients at 3rd Month Was Evaluated by DAS28 and ACR in Relation to JAK Expression
Interventions: DIAGNOSTIC_TEST: JAK expression
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Testing the Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy
Status: RECRUITING
Conditions: Chemotherapy-Induced Peripheral Neuropathy
Interventions: BEHAVIORAL: Exercise Intervention|OTHER: Tactile Sensitivity Test|OTHER: Questionnaire Administration|PROCEDURE: Brain Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Open Label Extension Study of Romiplostim (AMG 531) in Thrombocytopenic Patients With Immune (Idiopathic) Thrombocytopenic Purpura (ITP)
Status: COMPLETED
Conditions: Thrombocytopenia|Idiopathic Thrombocytopenic Purpura
Interventions: BIOLOGICAL: Romiplostim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effects of Eplerenone and Amlodipine on Blood Pressure and Basal Metabolic Rate in Obese Hypertensives
Status: TERMINATED
Conditions: Obesity|Hypertension
Interventions: DRUG: eplerenone, amlodipine|DRUG: eplerenone|DRUG: eplerenone|DRUG: amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Combination of Lactase and L. Salivarius DSM 34078 in Individuals With Lactose Intolerance
Status: COMPLETED
Conditions: Lactose Intolerance
Interventions: DIETARY_SUPPLEMENT: Active 1|DIETARY_SUPPLEMENT: Active 2|DIETARY_SUPPLEMENT: Active 3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Pain and Functional Patient Outcomes After Functional Endoscopic Sinus Surgery
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Bupivacaine Block|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Lapatinib in Children With Recurrent or Refractory Ependymoma
Status: COMPLETED
Conditions: Brain Cancer|Pediatric Cancers
Interventions: DRUG: Bevacizumab|DRUG: Lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of IMU-131(HER-Vaxx) and Chemotherapy Compared to Chemotherapy Only in Patients With HER2 Positive Advanced Gastric Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastrointestinal Neoplasms|Adenocarcinoma
Interventions: BIOLOGICAL: IMU-131|DRUG: Cisplatin and either Fluorouracil (5-FU) or Capecitabine or Oxaliplatin and capecitabine.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of Xaliproden (SR57746A) in Preventing the Neurotoxicity of Oxaliplatin / 5FU/LV Chemotherapy.
Status: COMPLETED
Conditions: Metastases|Colorectal Neoplasms|Colorectal Carcinoma
Interventions: DRUG: Xaliproden (SR57746A)|DRUG: Placebo|DRUG: Oxaliplatin|DRUG: 5-Fluorouracil|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pemetrexed Maintenance in Patients With Urothelial Carcinoma Who Completed First Line Platinum-based Chemotherapy
Status: UNKNOWN
Conditions: Bladder Cancer|Ureter Cancer|Transitional Cell Carcinoma
Interventions: DRUG: pemetrexed|DRUG: Folic Acid|DRUG: Vitamin B12 Injection|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Differences Between Canagliflozin and Placebo in Insulin Secretion in Subjects With Type 2 Diabetes Mellitus (T2DM)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Canagliflozin, 100 mg|DRUG: Canagliflozin, 300 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: GSL Synthetase Inhibitor in Combination With Immune Checkpoint Inhibitor in Previously Treated Blood and Solid Tumor
Status: COMPLETED
Conditions: Solid Tumor|Hematologic Malignancy
Interventions: DRUG: Eliglustat|DRUG: Immune checkpoint inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Distal Pharyngeal Airway for Oxygenation During TEE
Status: RECRUITING
Conditions: Airway Obstruction
Interventions: DEVICE: McMurray Enhanced Airway|DEVICE: Nasal Cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Integration of Health Coaching and Diabetes Education in Type 2 Diabetes Mellitus Management at Primary Health Care
Status: UNKNOWN
Conditions: Type2 Diabetes|Diabetes Mellitus, Type 2|Endocrine System Diseases|Nutritional and Metabolic Diseases|Glucose Metabolism Disorders (Including Diabetes Mellitus)|Diabetes Mellitus
Interventions: BEHAVIORAL: Personal Health Coaching and Diabetes Education in Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Immunogenicity and Safety of PPV23 Vaccine Revaccinations in the Elderly
Status: COMPLETED
Conditions: Vaccination
Interventions: BIOLOGICAL: 23-valent pneumococcal polysaccharide vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Modified Constraint-Induced Movement Therapy in Children With Hemiparetic Cerebral Palsy
Status: COMPLETED
Conditions: Spastic Hemiplegic Cerebral Palsy
Interventions: OTHER: Consecutive Modified Constraint-Induced Movement Therapy|OTHER: Traditional physiotherapy|OTHER: Intermittent Modified Constraint-Induced Movement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY III)
Status: TERMINATED
Conditions: Agitation|Dementia
Interventions: DRUG: BXCL501|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety/Efficacy Study With Armodafinil (CEP-10953) in Treatment of Excessive Sleepiness Associated With Chronic SWSD
Status: COMPLETED
Conditions: Excessive Sleepiness|Shift Work Sleep Disorder
Interventions: DRUG: Armodafinil 150 mg/day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of HS-10342 in Chinese Patients With HR+/HER2- Advanced and/or Metastatic Breast Cancer
Status: UNKNOWN
Conditions: HR+/HER2- Advanced and/or Metastatic Breast Cancer
Interventions: DRUG: HS-10342
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short-term Effect of Pomegranate Juice on Blood Sugar and Its Controlling Hormones in Pre-diabetic and Type II Diabetic Patients.
Status: COMPLETED
Conditions: Patients With Type 2 Diabetes (FSG: More Than 7.1 and Not Higher Than 15.8 mmol/L)
Interventions: OTHER: Fresh pomegranate juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home-based Transcranial Direct Current Stimulation in Fibromyalgia Patients
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: OTHER: Active-tDCS|OTHER: Sham-tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Integrating Mental Health Into a HIV Clinic to Improve Outcomes Among Tanzanian Youth
Status: COMPLETED
Conditions: Health Behavior|HIV|Mental Health
Interventions: BEHAVIORAL: Mental Health Intervention|BEHAVIORAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combined Anabolic Therapy
Status: NOT_YET_RECRUITING
Conditions: Osteoporosis, Postmenopausal|Osteoporosis
Interventions: DRUG: Romosozumab|DRUG: Teriparatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Group-Based Intervention to Improve Mental Health and Adherence Among Youth Living With HIV in Low Resource Settings
Status: RECRUITING
Conditions: HIV-1-infection
Interventions: BEHAVIORAL: TI-CBT Intervention Arm|BEHAVIORAL: Discussion Control Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prehabilitation Soft-Tissue Sarcoma of Lower Limb
Status: UNKNOWN
Conditions: Soft Tissue Sarcoma
Interventions: OTHER: Exercises|OTHER: Informational Support Group (Control group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: MRI and Blood Biomarkers for the Prediction of Neurocognitive Decline Following Brain Radiation
Status: RECRUITING
Conditions: Brain Neoplasm
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Multiparametric Magnetic Resonance Imaging|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Impact of Hormone Therapy on Lower Urinary Tract Symptoms, Sexual Function and Psychosomatic Disorder
Status: COMPLETED
Conditions: Menopausal Syndromes
Interventions: DRUG: Tibolone|DRUG: Estradiol & medroxyprogesterone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitd and Barrier Function in IBD
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: Soya Bean oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Efficacy and Safety of Ciclesonide (CIC) Administered Twice Daily in Pediatric Patients With Asthma.
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Ciclesonide|DRUG: Ciclesonide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Ann Arbor Stage III Hodgkin Lymphoma|Ann Arbor Stage III Lymphocyte-Depleted Classic Hodgkin Lymphoma|Ann Arbor Stage III Mixed Cellularity Classic Hodgkin Lymphoma|Ann Arbor Stage III Nodular Sclerosis Classic Hodgkin Lymphoma|Ann Arbor Stage IV Hodgkin Lymphoma|Ann Arbor Stage IV Lymphocyte-Depleted Classic Hodgkin Lymphoma|Ann Arbor Stage IV Mixed Cellularity Classic Hodgkin Lymphoma|Ann Arbor Stage IV Nodular Sclerosis Classic Hodgkin Lymphoma|Classic Hodgkin Lymphoma|Lymphocyte-Rich Classic Hodgkin Lymphoma
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Brentuximab Vedotin|PROCEDURE: Computed Tomography|DRUG: Dacarbazine|DRUG: Doxorubicin Hydrochloride|BIOLOGICAL: Filgrastim|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Nivolumab|BIOLOGICAL: Pegfilgrastim|PROCEDURE: Positron Emission Tomography|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|RADIATION: Radiation Therapy|DRUG: Vinblastine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II NabPaclitaxel, Paclitaxel&Carboplatin w RTX Followed by Consolidation in Patients w Favorable Prognosis Inoperable Stage IIIA/B NSCLC
Status: COMPLETED
Conditions: STAGE IIIA/B NSCLC / INOPERABLE LUNG CANCER
Interventions: DRUG: NAB-PACLITAXEL|DRUG: PACLITAXEL|DRUG: NAB-PACLITAXEL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical and Functional Effects of Online Exercise Program on Musicians Playing Stringed Instruments
Status: RECRUITING
Conditions: Musculoskeletal Diseases or Conditions|Musculoskeletal Pain
Interventions: OTHER: The exercise program|OTHER: Online education presentation|DEVICE: Smart band
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Propofol and Thiopental on Nitric Oxide Production and Release in Erythrocytes
Status: COMPLETED
Conditions: Effect of Drug
Interventions: DRUG: Propofol|DRUG: Thiopental
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Intradermal (ID) BOTOX in the Treatment of Facial Fine Lines
Status: COMPLETED
Conditions: Facial Fine Lines
Interventions: DRUG: Botox|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effectiveness and Safety of Treatment With Vedolizumab in Adult Participants With Ulcerative Colitis (UC) or Crohn's Disease (CD) in Real Life
Status: TERMINATED
Conditions: Colitis, Ulcerative|Crohn Disease|Inflammatory Bowel Diseases
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 2a MIB-626 vs. Placebo COVID-19
Status: COMPLETED
Conditions: Covid19|Stage 1 Acute Kidney Injury
Interventions: DRUG: MIB-626|DRUG: Placebo|OTHER: Home Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Based on the Use of Mononuclear Cells From Autologous Bone Marrow in Patients With Pseudoarthrosis
Status: COMPLETED
Conditions: Pseudoarthrosis
Interventions: PROCEDURE: ABM seeded onto a porous TCP and DBM|PROCEDURE: autologous bone graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Infarct Size by Transforming Emergent Stenting Into an Elective Procedure Study
Status: UNKNOWN
Conditions: Myocardial Infarction
Interventions: PROCEDURE: Immediate stenting|PROCEDURE: Delayed stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ciprofloxacin Therapy in Avoidance of Sepsis in Patient Undergoing Percutanous Nephrolithotomy
Status: UNKNOWN
Conditions: Nephrolithiasis
Interventions: DRUG: Ciprofloxacin|DRUG: Levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of CIMT With and Without MIT on Upper Limb of Children With Hemiparetic CP
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: DEVICE: Modified Constraint Induced Movement Therapy|OTHER: Motor Imagery Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dexlansoprazole Absorption and Marginal Ulceration After Gastric Bypass
Status: WITHDRAWN
Conditions: Bariatric Surgery
Interventions: DIAGNOSTIC_TEST: dexlansoprazole serum concentration|DIAGNOSTIC_TEST: upper endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Efficacy of Intracoronary Lithotripsy Balloon Catheter and Intracoronary Lithotripsy Apparatus
Status: RECRUITING
Conditions: Coronary Artery Disease|Intravascular Lithotripsy
Interventions: DEVICE: Intracoronary lithotripsy balloon catheter and Intracoronary lithotripsy apparatus|DEVICE: Dragonfly Opstar Imaging Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Mometasone Furoate/Formoterol Combination and Fluticasone/Salmeterol in Persistent Asthmatics Previously Treated With Inhaled Glucocorticosteroids (P04139)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: mometasone furoate combination MDI 200/10 mcg BID|DRUG: mometasone furoate combination MDI 400/10 mcg BID|DRUG: Fluticasone/Salmeterol 250/50 mcg BID|DRUG: Fluticasone/Salmeterol 500/50 mcg BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Two Methods in the Acceleration of the Retraction of Upper Canines
Status: COMPLETED
Conditions: Malocclusion, Angle Class II, Division 1
Interventions: PROCEDURE: Cortico-alveolar perforations|PROCEDURE: Traditional Corticotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telerehabilitation in the Home Versus Therapy In-Clinic for Patients With Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Telerehabilitation Therapy|BEHAVIORAL: In-Clinic Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erlotinib and Sorafenib in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme
Status: COMPLETED
Conditions: Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Recurrent Adult Brain Tumor
Interventions: DRUG: erlotinib hydrochloride|DRUG: sorafenib tosylate|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing the Number of Hospital Admissions With Multiple Nursing Interventions in COPD Patients Using Oxygen Concentrators at Home
Status: RECRUITING
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: health education|OTHER: Mobile application (Creating a WhatsApp group):|OTHER: Home visit:|OTHER: Telephone interview:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Long-Term Safety of Vildagliptin as Add-on Therapy to Metformin in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Vildagliptin|DRUG: Metformin|DRUG: Placebo|DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of the Safety, Efficacy and Dose Evaluation of ProSavin for the Treatment of Bilateral Idiopathic Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: BIOLOGICAL: ProSavin|BIOLOGICAL: ProSavin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UCLA Health Patient Health Maintenance Outreach Text Message
Status: ACTIVE_NOT_RECRUITING
Conditions: Health Maintenance|Diabetes|Cancer
Interventions: BEHAVIORAL: Outreach Text Messages|BEHAVIORAL: Specific|BEHAVIORAL: General|BEHAVIORAL: Elevating Intentions|BEHAVIORAL: Prompting Action
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Yogurt Added With Bifidobacteria and Soluble Fiber on Bowel Function.
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases
Interventions: OTHER: yogurt added with bifidobacteria and soluble fiber (YBF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamics Aspects Of Porcine Heparin Sodium, Produced by Eurofarma, Compared Heparin Sodium, Produced by APP Pharmaceuticasls, in Patients With Chronic Renal Failure
Status: UNKNOWN
Conditions: Pharmacodynamics
Interventions: BIOLOGICAL: Suine|BIOLOGICAL: Suine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Application of Virtual Mandibular Position in Temporomandibular Jont Reconstruction With Costochondral Graft in Children Jaw Deformity
Status: RECRUITING
Conditions: Temporomandibular Joint Ankylosis|Facial Asymmetry
Interventions: PROCEDURE: temporomandibular jont reconstruction with costochondral transplantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Modification of the Stylet Shape of the Glidescope for Facilitating Difficult Intubation
Status: NOT_YET_RECRUITING
Conditions: Difficult Intubation
Interventions: DEVICE: Gliderite® shape modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Adagrasib in Combination With Palbociclib in Patients With Advanced Solid Tumors (KRYSTAL-16)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: MRTX849|DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective, Multicentric Study Evaluating the Surgical Treatment by Mastectomy With Immediate Prosthetic Breast Reconstruction in Patients With Breast Cancer and Receiving Adjuvant Therapy by TomoTherapy +/-Chemotherapy.
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer Invasive
Interventions: OTHER: Patients with invasive breast cancer will receive:
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: VR to Reduce Pain and Anxiety During GU Scans
Status: ACTIVE_NOT_RECRUITING
Conditions: Urologic Diseases|Urogenital Disease|Vesico-Ureteral Reflux
Interventions: DEVICE: Oculus Go VR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Conceptualisation of a Network Approach to Complete the Classification of Eating Disorders With the Aim of Better Personalising Their Management
Status: NOT_YET_RECRUITING
Conditions: Eating Disorders|Eating Disorder Binge
Interventions: BEHAVIORAL: Ambulatory cares in a day-hospital (Lapeyronie, Montpellier) specialized in the evaluation of eating disorders.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Sirolimus in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: sirolimus|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of HQK-1001 Administered Daily in Patients With Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: Placebo|DRUG: HQK-1001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Collis-Nissen for the Treatment of Short Esophagus
Status: COMPLETED
Conditions: Gastro-esophageal Reflux Diseases|Short Esophagus
Interventions: PROCEDURE: Antireflux Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Adding Enfuvirtide to Oral Highly Active Antiretroviral Therapy (HAART) in Human Immunodeficiency Virus (HIV) Patients With Prior Treatment Experience
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Enfuvirtide|DRUG: Highly active antiretroviral treatment (HAART)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Utilisation and Effectiveness of Originator and Biosimilar Anti-TNF Agents
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Psoriatic Arthritis|Ankylosing Spondylitis
Interventions: BIOLOGICAL: Originator|BIOLOGICAL: Biosimilar
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A PhaseⅠb Study Evaluating Safety and Efficacy of C-CAR011 Treatment in B- NHL Subjects
Status: COMPLETED
Conditions: B-cell Non-Hodgkin Lymphoma
Interventions: BIOLOGICAL: CD19-directed CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of IBI-10090 for the Treatment of Inflammation Associated With Cataract Surgery
Status: COMPLETED
Conditions: Inflammation|Cataracts
Interventions: DRUG: IBI-10090|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Abuse Potential of HORIZANT With and Without Oxycodone in Healthy, Nondependent Recreational Opioid Users
Status: COMPLETED
Conditions: Abuse Potential
Interventions: DRUG: Placebo|DRUG: Oxycodone 20 mg|DRUG: GE-IR 200 mg|DRUG: GE-IR 450 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: First Human Dose Trial of NNC0215-0384 in Subjects With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Inflammation|Rheumatoid Arthritis
Interventions: DRUG: NNC0215-0384|DRUG: placebo|DRUG: NNC0215-0384
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MIBG for Refractory Neuroblastoma and Pheochromocytoma
Status: SUSPENDED
Conditions: Relapsed Neuroblastoma|Metastatic Pheochromocytoma
Interventions: DRUG: 131 I-Metaiodobenzylguanidine (131I-MIBG)|DRUG: Potassium iodide solution|DRUG: G-CSF|PROCEDURE: hematopoietic stem cell infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Coaching Strategy on Some Patient Outcomes After Total Knee Arthroplasty Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Anxiety|Self Efficacy|Patient Satisfaction|Lifestyle-related Condition
Interventions: OTHER: Nursing Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Glofitamab and Lenalidomide in People With Mantle Cell Lymphoma
Status: RECRUITING
Conditions: Mantle Cell Lymphoma|MCL
Interventions: DRUG: Glofitamab|DRUG: Obinutuzumab|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate Palifermin in the Reduction of Acute Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Allogeneic Marrow/Peripheral Blood Progenitor Cell (PBPC) Transplantation
Status: COMPLETED
Conditions: Graft Versus Host Disease|Hematologic Malignancies
Interventions: DRUG: Palifermin|DRUG: Placebo|OTHER: Conditioning Regimen|PROCEDURE: Allogeneic stem cell transplant|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Therapeutic Play on Pain, Fear, Anxiety and Physiological Parameters and Parents' Satisfaction
Status: COMPLETED
Conditions: Child Behavior|Pain, Acute|Anxiety and Fear
Interventions: BEHAVIORAL: Video game with headset
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of the Safety and Efficacy of APX3330 in Diabetic Retinopathy
Status: COMPLETED
Conditions: Diabetic Retinopathy|Diabetic Macular Edema|NPDR - Non Proliferative Diabetic Retinopathy|PDR - Proliferative Diabetic Retinopathy
Interventions: DRUG: APX3330|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multidisciplinary Approach for Poor Prognosis Sinonasal Tumors in Inoperable Patients
Status: UNKNOWN
Conditions: Unresectable Sinonasal Tumors
Interventions: DRUG: Cisplatin|DRUG: Docetaxel|DRUG: 5-fluorouracil|DRUG: Etoposide|DRUG: Adriamycin|DRUG: Ifosfamide|DRUG: Leucovorin|RADIATION: Radiotherapy - Patients needing Elective Nodal Volume (ENI)|RADIATION: Radiotherapy - Patients not needing ENI|RADIATION: Radiotherapy - Patients needing curative neck irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Vaporized Marijuana on Neuropathic Pain
Status: COMPLETED
Conditions: Neuropathic Pain|Reflex Sympathetic Dystrophy|Peripheral Neuropathy|Post-herpetic Neuralgia|Spinal Cord Injury|Multiple Sclerosis
Interventions: DRUG: Mild dose cannabis|DRUG: Low dose cannabis|DRUG: Cannabis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Plaque Removal Versus Open Bypass Surgery For Critical Limb Ischemia
Status: TERMINATED
Conditions: Peripheral Vascular Diseases
Interventions: PROCEDURE: Bypass|PROCEDURE: Silverhawk Plaque Excision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trail Evaluating Carbon Ion Radiotherapy for Locally Recurrent Nasopharyngeal Carcinoma
Status: TERMINATED
Conditions: Nasopharyngeal Carcinoma
Interventions: RADIATION: Carbon ion radiotherapy (CIRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalency Study of Mycophenolate Mofetil 500 mg Tablets Under Fasted Conditions
Status: COMPLETED
Conditions: Prophylaxis of Organ Rejection
Interventions: DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AVB-S6-500 and Durvalumab in Treating Patients With Platinum-Resistant or Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Platinum-Resistant Fallopian Tube Carcinoma|Platinum-Resistant Ovarian Carcinoma|Platinum-Resistant Primary Peritoneal Carcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Refractory Fallopian Tube Carcinoma|Refractory Ovarian Carcinoma|Refractory Primary Peritoneal Carcinoma
Interventions: DRUG: Batiraxcept|BIOLOGICAL: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TAK-659 in Combination With NKTR-214 in Participants With Advanced Non-Hodgkin Lymphoma (NHL)
Status: WITHDRAWN
Conditions: Lymphoma, Non-Hodgkin
Interventions: DRUG: TAK-659|DRUG: NKTR-214
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate Effect of a New Drug (PF-00446687) in Males Suffering From Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: PF-00446687|DRUG: Placebo|DRUG: Placebo|DRUG: Sildenafil|DRUG: PF-00446687|DRUG: PF-00446687|DRUG: PF-00446687|DRUG: Placebo|DRUG: Placebo|DRUG: Sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Self- and Balloon-expandable Valves in Patients With Ascending Aortic Dilation Undergoing Transcatheter Aortic Valve Replacement: The AAD-CHOICE
Status: RECRUITING
Conditions: Aortic Stenosis|Ascending Aortic Dilatation
Interventions: DEVICE: self-expandable valves|DEVICE: balloon-expandable valves
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of L-lysine on Adrenal Secretion
Status: COMPLETED
Conditions: Male|Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: L-lysine|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Conventional Versus Robot Assisted Laparoscopic Inguinal Hernia Repair
Status: RECRUITING
Conditions: Inguinal Hernia
Interventions: PROCEDURE: r-TAPP|PROCEDURE: l-TAPP|PROCEDURE: local anesthetics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Metformin Add-on Regimen Comparison Study in Japanese Participants With Type 2 Diabetes Mellitus (MK-0431A-136)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin|DRUG: Metformin|DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Development of a MR Scanner Capable of Being Sited in a Neonatal Intensive Care Unit (Firefly Sheffield)
Status: COMPLETED
Conditions: Neonatal Neuroimaging
Interventions: DEVICE: 3.0 T Neonatal MRI scanner
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Long-Term Effect of Adolescent Diet on Hormones and Breast Cancer Risk in Women Previously Enrolled in the Dietary Intervention Study in Children
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: physiologic testing|OTHER: questionnaire administration|PROCEDURE: breast imaging study|PROCEDURE: dual x-ray absorptometry|PROCEDURE: evaluation of cancer risk factors|PROCEDURE: magnetic resonance imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Timing of Initiation of Continuous Glucose Monitoring in Established Pediatric Diabetes (The CGM TIME Trial)
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: Simultaneous RT-CGM and Pump Initiation|DEVICE: Delayed Initiation of RT-CGM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Fludrocortisone on Norepinephrine-mean Arterial Pressure Dose-response in Septic Shock
Status: WITHDRAWN
Conditions: Septic Shock
Interventions: DRUG: Fludrocortisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of CPAP in the Worsening of Renal Function in Early Stages of Chronic Kidney Disease (CKD)
Status: UNKNOWN
Conditions: Chronic Kidney Insufficiency|Sleep Apnea
Interventions: DEVICE: CPAP|OTHER: conservative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of Ecopipam in Adults With Childhood Onset Fluency Disorder (Stuttering).
Status: UNKNOWN
Conditions: Stuttering, Adult|Childhood-onset Fluency Disorder|Speech Disorders|Language Disorders|Communication Disorder
Interventions: DRUG: Ecopipam 50mg|DRUG: Ecopipam 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Salmeterol/Fluticasone Propionate vs Atropium/Albuterol in Patients COPD
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Salmeterol/Fluticasone Propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conventional Oxygen Therapy Versus Continuous Transnasal High Flow Oxygen Therapy for Head and Neck Diagnostic Panendoscopy Under General Anesthesia in Spontaneous Ventilation
Status: RECRUITING
Conditions: Head and Neck Cancer
Interventions: PROCEDURE: Respiratory Gas Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of the ASPEN Intervention Program in Low-Resource Communities
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: ASD Screening Parent ENgagement Intervention Program (ASPEN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine Whether Epoetin Alfa Can Reduce the Need for Blood Transfusions in Patients During the Period of Time Around Major Orthopedic Surgery.
Status: COMPLETED
Conditions: Anemia|Blood Transfusion|Orthopedic Procedures
Interventions: DRUG: epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Patient-reported and Clinical Outcomes in Adults With Relapsed or Refractory Hodgkin's Lymphoma Receiving Brentuximab Vedotin
Status: UNKNOWN
Conditions: Relapsed or Refractory Hodgkin's Lymphoma
Interventions: DRUG: Brentuximab Vedotin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: GB1211 and Pembrolizumab Versus Pembrolizumab and Placebo in Patients With Metastatic Melanoma and Head and Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Metastatic Melanoma|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: GB1211|DRUG: Pembrolizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of CC-90005 in Healthy Subjects and Subjects With Moderate to Severe Plaque-type Psoriasis
Status: TERMINATED
Conditions: Parapsoriasis|Healthy Volunteers
Interventions: DRUG: CC-90005|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Double-blind, Placebo Controlled, Randomized INTerventional Clinical Trial (SARA-INT)
Status: COMPLETED
Conditions: Sarcopenia|Gait Disorders in Old Age|Muscle Weakness
Interventions: DRUG: BIO101|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Ecological Rythmic-acoustic Stimulation (E-RAS) on Motor Skills in Individuals With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: Administration of rhytmic acoustic stimuli for gait training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: User Evaluation of the Peristomal Skin Condition in Ostomates Using ConvaTec Moldable Technology™
Status: UNKNOWN
Conditions: Colostomy|Ileostomy|Urostomy
Interventions: DEVICE: Esteem Plus with ConvaTec Moldable Technology|DEVICE: Natura with ConvaTec Moldable Technology|DEVICE: Natura Accordion with ConvaTec Moldable Technology|DEVICE: Esteem synergy Plus with ConvaTec Moldable Technology
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects on Glucose Homeostasis of Changes in Plasma Lipoproteins Induced by Nutritional and Pharmacologic Strategies
Status: ENROLLING_BY_INVITATION
Conditions: Glucose Metabolism Disorders
Interventions: DIETARY_SUPPLEMENT: Intermittent Fasting|DRUG: Fibrates|DIETARY_SUPPLEMENT: Low-Carbohydrate/High-Protein diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Management of Severe Acute Malnutrition in SCD, in Northern Nigeria
Status: COMPLETED
Conditions: Sickle Cell Anemia|Severe Acute Malnutrition
Interventions: DRUG: hydroxyurea (20mg/kg/day)|DIETARY_SUPPLEMENT: Ready-to-use therapeutic food
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Intervention for Developmental Delay
Status: COMPLETED
Conditions: Child Development|Developmental Delay|Early Intervention
Interventions: BEHAVIORAL: Day-Care early intervention program|BEHAVIORAL: OPD+SI intervention program|BEHAVIORAL: OPD intervention program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetically Engineered Cells (Anti-CD19/CD20/CD22 CAR T-cells) for the Treatment of Relapsed or Refractory Lymphoid Malignancies
Status: RECRUITING
Conditions: Recurrent Acute Lymphoblastic Leukemia|Recurrent B Acute Lymphoblastic Leukemia|Recurrent B-Cell Prolymphocytic Leukemia|Recurrent Chronic Lymphocytic Leukemia|Recurrent High Grade B-Cell Lymphoma|Recurrent Indolent Non-Hodgkin Lymphoma|Recurrent Non-Hodgkin Lymphoma|Recurrent Transformed Chronic Lymphocytic Leukemia|Refractory Acute Lymphoblastic Leukemia|Refractory B Acute Lymphoblastic Leukemia|Refractory B-Cell Prolymphocytic Leukemia|Refractory Chronic Lymphocytic Leukemia|Refractory High Grade B-Cell Lymphoma|Refractory Indolent Non-Hodgkin Lymphoma|Refractory Non-Hodgkin Lymphoma|Refractory Transformed Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: Anti-CD19/CD20/CD22 CAR T-Cells|DRUG: Cyclophosphamide|DRUG: Fludarabine Phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Acute Myelogenous Leukemia|Mixed Phenotype Acute Leukemia|Acute Leukemia|Myelodysplastic Syndromes|Chronic Myelogenous Leukemia|Chronic Lymphocytic Leukemia|Lymphoma
Interventions: DRUG: Busulfan|DRUG: Busulfan|DRUG: Fludarabine|RADIATION: Total-body irradiation|DRUG: Cyclophosphamide|DRUG: Melphalan|PROCEDURE: PBSC Hematopoietic Stem Cell Transplantation (HSCT)|PROCEDURE: Bone Marrow Hematopoietic Stem Cell Transplantation|DRUG: Post-transplant Cyclophosphamide|DRUG: Mesna|DRUG: Tacrolimus|DRUG: Mycophenolate Mofetil|OTHER: Patient-Reported Outcomes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IV Administration of ChromaDex's Niagen® as Compared to NAD+
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Aging
Interventions: DIETARY_SUPPLEMENT: NAD+ (nicotinamide adenine dinucleotide) IV|DIETARY_SUPPLEMENT: Niagen® (nicotinamide riboside) IV|DIETARY_SUPPLEMENT: Niagen® (nicotinamide riboside) oral|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER