pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Efficacy of Guided Tissue Regeneration With Extracellular Matrix Scaffold of Small Intestinal Submucosa (SIS) Membrane: a Randomized Controlled Clinical Trial
Status: RECRUITING
Conditions: Guided Tissue Regeneration|Extracellular Matrix Scaffold of Small Intestinal Submucosa
Interventions: PROCEDURE: Flap surgery+bone graft+guided tissue regeneration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IVL vs ELCA for Stent Underexpantsion (IVL-ELCA DRAGON)
Status: COMPLETED
Conditions: Coronary Artery Calcification|Intravascular Lithotripsy|Excimer Laser-coronary Atherectomy|Stent Restenosis|Stent Occlusion
Interventions: DEVICE: Stent Underexpansion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Human Placenta-derived Cells (PDA001) to Evaluate the Safety and Effectiveness for Patients With Ischemic Stroke
Status: TERMINATED
Conditions: Stroke, Acute|Middle Cerebral Artery Stroke|Posterior Cerebral Artery Stroke
Interventions: BIOLOGICAL: Human Placenta-Derived Cells PDA001- (cenplacel-L)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of T Cell Depleted Allogeneic Non-myeloablative Stem Cell Transplant
Status: COMPLETED
Conditions: Hodgkin's Disease|Non Hodgkin's Lymphoma|Myeloma|Leukemia|Myelodysplasia
Interventions: DRUG: Non-myeloablative Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A(B)VD Followed by Nivolumab as Frontline Therapy for Higher Risk Patients With Classical Hodgkin Lymphoma (HL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Hodgkin Lymphoma
Interventions: DRUG: doxorubicin|DRUG: Bleomycin|DRUG: vinblastine|DRUG: dacarbazine|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low -vs- High-Frequency Repetitive TMS of the Right Dorsolateral Prefrontal Cortex in PTSD
Status: TERMINATED
Conditions: PTSD - Post Traumatic Stress Disorder
Interventions: OTHER: Active Comparator: 1 Hz rTMS|OTHER: Active Comparator: 10 Hz rTMS|OTHER: Sham Comparator:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Elderly Metastatic Breast Cancer: Pertuzumab-Herceptin vs Pertuzumab-Herceptin-Metronomic Chemotherapy, Followed by T-DM1
Status: COMPLETED
Conditions: Elderly Metastatic Breast Cancer Population
Interventions: DRUG: Pertuzumab + trastuzumab|DRUG: Pertuzumab + trastuzumab + metronomic chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AKB-9778 Ophthalmic Solution
Status: COMPLETED
Conditions: Ocular Hypertension|Primary Open Angle Glaucoma
Interventions: DRUG: AKB-9778 Ophthalmic Solution|DRUG: Placebo Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Pea Proteins on Muscle Damage and Recovery
Status: COMPLETED
Conditions: Pea Proteins|Muscle Damage|Amino Acid Change
Interventions: DIETARY_SUPPLEMENT: Active Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of HIPEC After Radical Surgery on Long-term Survival for Locally Advanced Gastric Cancer
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer|Survival Rate
Interventions: DRUG: cisplatin oxaliplatin tegafur
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Immunogenicity of Two Different Formulations of Meningococcal B Recombinant Vaccine, When Administered to Healthy Infants
Status: COMPLETED
Conditions: Meningococcal Disease
Interventions: BIOLOGICAL: rMenB|BIOLOGICAL: rMenB+OMV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Determinants of Repeated Spontaneous Miscarriages and Unexplained Fetal Deaths
Status: NOT_YET_RECRUITING
Conditions: Repeated Spontaneous Miscarriages|Fetal Deaths in Utero
Interventions: BIOLOGICAL: biological sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Combination of Radiation Therapy and Anti-PD-1 Antibody SHR-1210 in Treating Patients With Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Neoplasms|Esophageal Diseases|Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Radiation|DRUG: SHR-1210
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety & Efficacy of FLX-787-ODT to Treat Fasciculations in Tongue and Upper or Lower Extremity Muscles Most Affected in Subjects With ALS
Status: WITHDRAWN
Conditions: Amyotrophic Lateral Sclerosis|Fasciculation
Interventions: DRUG: FLX-787-ODT (orally disintigrating tablet)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Intrahepatic Cholangiocarcinoma|Cholangiocarcinoma|Primary Liver Cancer|Primary Liver Carcinoma|Hepatic Cancer|Hepatic Carcinoma
Interventions: DIAGNOSTIC_TEST: ELUCIDATE
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 2 Trial of Durvalumab With or Without Bavituximab in Patients With Previously Treated Metastatic Non-small-cell Lung Cancer
Status: WITHDRAWN
Conditions: Non-Small Cell Lung Cancer
Interventions: BIOLOGICAL: durvalumab|BIOLOGICAL: bavituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate of EXG34217 in Patients With Telomere Biology Disorders With Bone Marrow Failure
Status: RECRUITING
Conditions: Telomere Shortening|Bone Marrow Failure
Interventions: BIOLOGICAL: EXG34217
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Parameters Between a Frameless Brain Biopsy Method and the Standard Frame-based Stereotactic Biopsy
Status: COMPLETED
Conditions: Lesion of Brain
Interventions: PROCEDURE: Brain biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Randomized Controlled Study on T-PEP Versus IPV Method for Lower Respiratory Airways Clearance in Tetraplegic Tracheotomized Spinal Cord Injured Patients
Status: WITHDRAWN
Conditions: Spinal Cord Injury Cervical
Interventions: PROCEDURE: T-PEP|PROCEDURE: IPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lithium Water in Gun Violence Prevention
Status: UNKNOWN
Conditions: Assault by Handgun Discharge|Violence|Homicide|Sexual Assault by Bodily Force|Substance Abuse Problem
Interventions: DIETARY_SUPPLEMENT: Lithium Water|DIETARY_SUPPLEMENT: placebo: spring mineral water|OTHER: natural spring water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial of Extracorporeal Photopheresis, Pentostatin, and Total Body Irradiation in Patients Undergoing Reduced Intensity Allogeneic Stem Cell Transplantation for the Treatment of Malignancies
Status: COMPLETED
Conditions: Hematologic Malignancies
Interventions: PROCEDURE: extracorporeal photopheresis|DRUG: Pentostatin|RADIATION: Total Body Irradiation|DRUG: Pentostatin|RADIATION: Total Body Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Prometic Plasminogen IV Infusion in Subjects With Hypoplasminogenemia
Status: COMPLETED
Conditions: Hypoplasminogenemia|Congenital Plasminogen Deficiency
Interventions: BIOLOGICAL: Plasminogen (Human) intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Prognostic Biomarkers, Host Factors and Viral Factors for COVID-19 in Children
Status: RECRUITING
Conditions: COVID-19-Associated Encephalitis|Multisystem Inflammatory Syndrome in Children
Interventions: OTHER: delineate its prognostic biomarker, host genetic factors, immunopathogenesis and viral pathogenesis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A First-in-human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM12460A
Status: COMPLETED
Conditions: Healthy|Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus
Interventions: DRUG: HM12460A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Early-Stage Hodgkin's Disease
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: bleomycin sulfate|DRUG: Stanford V regimen|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: mechlorethamine hydrochloride|DRUG: prednisone|DRUG: vinblastine sulfate|DRUG: vincristine sulfate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: MART-1 antigen|BIOLOGICAL: aldesleukin|BIOLOGICAL: gp100 antigen
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation of Regeneten Augmentation for Subscapularis Healing After Total Shoulder Arthroplasty (RESTOR)
Status: ACTIVE_NOT_RECRUITING
Conditions: Arthroplasty, Replacement, Shoulder
Interventions: DEVICE: Regeneten|PROCEDURE: Standard repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: In-office Placement of the Propel Mini Sinus Implant in the Frontal Sinus Ostia
Status: COMPLETED
Conditions: Chronic Sinusitis
Interventions: DEVICE: PROPEL Mini Sinus Implant|PROCEDURE: Balloon Sinus Dilation Alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Exchange of Azathioprine by Mycophenolatmofetile and Cyclosporine A Dose Reduction After Heart Transplantation
Status: COMPLETED
Conditions: Heart Transplantation
Interventions: DRUG: Mycophenolatmofetile|DRUG: Cyclosporin A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Pediatric Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (Ph+ALL)|Ph+ Mixed Phenotype Acute Leukemia (MPAL)|Philadelphia Chromosome-Like ALL (Ph-like ALL)
Interventions: DRUG: Ponatinib|DRUG: Ponatinib AAF|DRUG: Chemotherapy Agents
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MHealth Incentivized Adherence Plus Patient Navigation
Status: RECRUITING
Conditions: Opioid Use Disorder|Medication Adherence|Polysubstance Drug Use (Indiscriminate Drug Use)|Methamphetamine-dependence
Interventions: BEHAVIORAL: Patient Navigation and mHealth (PN+mHealth)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Adding Metformin to Insulin in Uncontrolled Diabetic Patients During the 3rd Trimester of Pregnancy
Status: COMPLETED
Conditions: Diabetes Mellitus Pregnancy
Interventions: DRUG: Metformin|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Three-port Versus Conventional Laparoscopic Surgery for Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: PROCEDURE: Three-port Laparoscopic Surgery|PROCEDURE: Conventional Laparoscopic Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Observational Study to Evaluate the Efficacy of Biweekly Romiplostim in Adult Patients With ITP
Status: UNKNOWN
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Romiplostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Unilateral Versus Bilateral Pedicle Screw Fixation for Lumbar Degenerative Diseases
Status: UNKNOWN
Conditions: Fusion of Spine
Interventions: PROCEDURE: Unilateral Pedicle Screw Fixation|PROCEDURE: Bilateral Pedicle Screw Fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glucose Containing and Glucose Free Hemodialysate in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: End-Stage Kidney Disease|Type 2 Diabetes Mellitus
Interventions: OTHER: Glucose-containing compared to glucose-free hemodialysate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Esthetic Restorations Placed in Primary Molars With Composite Resin Enriched With Insoluble Anti Bacterial Nano Particles
Status: UNKNOWN
Conditions: Dental Carious|Dental Filling
Interventions: DEVICE: dental restoration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Multi-Centre Gastroschisis Interventional Study Across Sub-Saharan Africa
Status: UNKNOWN
Conditions: Gastroschisis
Interventions: COMBINATION_PRODUCT: Pre-hospital interventional care bundle|COMBINATION_PRODUCT: In-hospital interventional care bundle
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy With or Without Cyclophosphamide in Treating Patients With Recurrent or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: DRUG: Cyclophosphamide|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Oncolytic Measles Virus Encoding Thyroidal Sodium Iodide Symporter|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Controlled Study to Evaluate the Efficacy and Safety of the Treatment With Growth Hormone in Tibia Fractures
Status: COMPLETED
Conditions: Bone Fracture|Tibia Fractures
Interventions: DRUG: somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Versus Double Injection Costoclavicular Block
Status: UNKNOWN
Conditions: Upper Extremity Injury
Interventions: OTHER: Single injection|OTHER: Double injection|DRUG: lidocaine, bupivacaine, epinephrine, dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety Study of Cenderitide in Chronic Stable Heart Failure With Moderate Renal Impairment
Status: COMPLETED
Conditions: Heart Failure|Renal Insufficiency
Interventions: DRUG: Cenderitide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 3-Dimensional Form and Soft Tissue Biomechanics of the Breast
Status: TERMINATED
Conditions: Breast Cancer
Interventions: PROCEDURE: 3-D Optical Surface Scan|PROCEDURE: Mechanical Testing|PROCEDURE: Cutaneous Ultrasound|PROCEDURE: Breast MRI and/or CT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Test the Effectiveness of Different Interventions to Improve Physical Activity in Adults.
Status: COMPLETED
Conditions: Healthy
Interventions: BEHAVIORAL: Motivational Interviewing|BEHAVIORAL: Education|BEHAVIORAL: Wearable Fitness Trackers|BEHAVIORAL: Wearable Fitness Tracker+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vertical Bone Gain and Neurosensory Affection in Computer Guided vs Conventional Sandwich Osteotomy
Status: COMPLETED
Conditions: Bone Loss
Interventions: PROCEDURE: sandwich interpositional bone grafting computer guided|PROCEDURE: conventional interpositional bone grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenetic Response to Chemotherapy Induction for ORL Cancers
Status: COMPLETED
Conditions: Carcinoma, Squamous Cell|Mouth Neoplasms|Oropharyngeal Neoplasms|Laryngeal Neoplasms|Hypopharyngeal Neoplasms
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mulligan BLR Versus Mulligan TSLR Versus Neural Mobilization n Patient With Lumber Radiculopathy
Status: COMPLETED
Conditions: Lumbar Radiculopathy
Interventions: OTHER: Mulligan Bent Leg Raise|OTHER: Mulligan Traction Straight Leg Raise|OTHER: Neural Mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Nintedanib in Progressive Pneumoconiosis Study (NiPPS): a Collaborative NSW Treatment Trial
Status: RECRUITING
Conditions: Pneumoconiosis Coal|Asbestosis|Silicosis
Interventions: DRUG: Nintedanib 150 MG [Ofev]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 64Cu-DOTA-pembrolizumab PET for the Study of PD1 Expression
Status: WITHDRAWN
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: RADIATION: Copper Cu 64-DOTA-pembrolizumab|BIOLOGICAL: Pembrolizumab|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Use of an add-on Device Connected to a Smartphone App on Difficult-to-treat Asthmatic Patient's Adherence
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: Marketed experience application on adherence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of an Education Programme for Patients With Osteoarthritis in Primary Care - a Randomized Controlled Trial
Status: COMPLETED
Conditions: Osteoarthritis in the Hip, Knee and Hand
Interventions: OTHER: Patient education programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Peritoneal Dialysis on a Background of Thrice-Weekly Hemodialysis
Status: TERMINATED
Conditions: Functionally Anuric|Hemodialysis/Peritoneal Dialysis
Interventions: OTHER: Adjuvant Peritoneal Dialysis in the context of ongoing Hemodialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Renal Protocol Protection in CKD Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: HCC|CKD
Interventions: OTHER: low dose CT contrast media|OTHER: Standard dose CT contrast media
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Cardiovascular Risk Markers in Patients With Rheumatoid Arthritis: Effect of Rituximab Therapy
Status: COMPLETED
Conditions: Endothelial Function|Rheumatoid Arthritis|Inflammation
Interventions: DRUG: Rituxan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychopharmacological Treatment of Emotional Distress
Status: RECRUITING
Conditions: Suicide Crisis Syndrome|Psychological Distress
Interventions: DRUG: Clonazepam|DRUG: Olanzapine|DRUG: Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrapartum Maternal Oxygen Supplementation: Effects on the Mother and Neonate
Status: COMPLETED
Conditions: Intrauterine Resuscitation
Interventions: OTHER: No oxygen|OTHER: Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: De-escalation Radiation Strategy After NAC in Combination With ICI in LAHNSCC
Status: RECRUITING
Conditions: Locally Advanced Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: immunotherapy：pembrolizumab；chemo：albumin-bound paclitaxel and cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Supplementation During PR Participation in COPD
Status: RECRUITING
Conditions: Copd
Interventions: DIETARY_SUPPLEMENT: Urolithin A (Mitopure)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
Status: COMPLETED
Conditions: Pneumonia, Pneumocystis Carinii|HIV Infections
Interventions: DRUG: Trimetrexate glucuronate|DRUG: Sulfamethoxazole-Trimethoprim|DRUG: Leucovorin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Benefits of Tobacco Free Cigarette
Status: UNKNOWN
Conditions: Cigarette Smoking|Smoking Cessation
Interventions: BEHAVIORAL: Smoking cessation program TFC and activity tracker|BEHAVIORAL: Smoking cessation program TFC-free and activity tracker|BEHAVIORAL: Smoking cessation program and activity tracker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotics on Gut Microbiota During the Helicobacter Pylori Eradication
Status: NOT_YET_RECRUITING
Conditions: Helicobacter Pylori Infection|Gut Microbiota
Interventions: DIETARY_SUPPLEMENT: Bifidobacterium animalis subsp. lactis BLa80|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of Radiotherapy Administered in Combination With Ipilimumab in Patients With Unresectable Stage III or Stage IV Advanced Malignant Melanoma
Status: TERMINATED
Conditions: Malignant Melanoma
Interventions: DRUG: Ipilimumab|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Losartan on Hepatic Fibrogenesis in Chronic Hepatitis C
Status: COMPLETED
Conditions: Chronic Hepatitis C|Liver Fibrosis
Interventions: DRUG: Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Transcranial Direct Current Stimulation (tDCS) on Inhibition and Brain Function in Primary Progressive Aphasia
Status: NOT_YET_RECRUITING
Conditions: Aphasia, Primary Progressive
Interventions: DEVICE: tDCS|DEVICE: SHAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stress Management and Biological Age in Breast Cancer Patients.RCT
Status: RECRUITING
Conditions: Stress|Breast Cancer|Telomere Length, Mean Leukocyte
Interventions: BEHAVIORAL: PSAI|BEHAVIORAL: One day seminar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Corticosteroids as Additive in Temporomandibular Joint (TMJ) Arthrocentesis
Status: UNKNOWN
Conditions: Arthritis
Interventions: DRUG: Dexamethasone|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Islet Cell Transplantation Alone and CD34+ Donor Bone Marrow Cell Infusion in Type 1 Diabetes Mellitus
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus
Interventions: BIOLOGICAL: Islet Transplantation and Bone Marrow
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An mTLIP Block for Analgesia Management After Lumbar Spinal Surgery.
Status: COMPLETED
Conditions: Lumbar Disc Herniation
Interventions: OTHER: TLIP block group (group T)|OTHER: Wound infiltration group (group W)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetic Study of LTI-03 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Caveolin-1-Scaffolding-Protein-Derived Peptide (LTI-03)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of VELCADE Given as Retreatment to Multiple Myeloma Patients for Efficacy, Safety and Tolerability
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of PRL3-ZUMAB in Advanced Solid Tumors
Status: RECRUITING
Conditions: Gastric Cancer|Hepatocellular Carcinoma|Advanced Solid Tumor
Interventions: DRUG: PRL3-zumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bladder Complaints in Parkinson's Disease Effectiveness of Pelvic Floor Muscle Exercises and Electrical Stimulation
Status: RECRUITING
Conditions: Lower Urinary Tract Symptoms|Parkinson Disease
Interventions: OTHER: pelvic physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Study to Evaluate Long Term Efficacy, Safety and Tolerability of Repeated Dosing in Subjects With Crohn's Disease and Who Participated and Successfully Completed M14-115
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of a Transcatheter Tricuspid Valved Stent Graft in Patients With Carcinoid Heart Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Tricuspid Regurgitation|Tricuspid Valve Disease|Carcinoid Syndrome|Carcinoid Heart Disease
Interventions: DEVICE: Transcatheter Tricuspid Valved Stent Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketone Ester Effects on Biomarkers of Brain Metabolism and Cognitive Performance in Cognitively Intact Adults 55 Years Old or Older
Status: RECRUITING
Conditions: Metabolic Syndrome|Normal Cognition
Interventions: DIETARY_SUPPLEMENT: Ketone Ester drink|DIETARY_SUPPLEMENT: Placebo: isocaloric dextrose drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Daratumumab for Patients With Light Chain Amyloidosis
Status: RECRUITING
Conditions: Light Chain (AL) Amyloidosis
Interventions: DRUG: Dratumumab / Hyaluronidase Injection [Darzalex Faspro]|DRUG: Pomalidomide 4 MG|PROCEDURE: autologous stem cell transplantation (ASCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Dapagliflozin on Vascular Health in Patients With Type 2 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Endothelial Dysfunction
Interventions: DRUG: Dapagliflozin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sugammadex Versus Neostigmine for Postoperative Nausea and Vomiting After Laparoscopic Gynaecological Surgery
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Sugammadex|DRUG: Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Combined Active Treatment in Type 2 Diabetes With NASH
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 2 Diabetes|Non-alcoholic Steatohepatitis (NASH)|Non-alcoholic Fatty Liver Disease (NAFLD)
Interventions: DRUG: Empagliflozin 10mg oral tablet / Semaglutide 1mg pen injector|DRUG: Empagliflozin 10mg oral tablet and placebo pen injector matching semaglutide|DRUG: Placebo matching empagliflozin and placebo pen injector matching semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Vascular Effects of Serelaxin
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Serelaxin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of a Hybrid Face-To-Face and Online Mode of Delivering a Mindfulness-Based Dementia Caregiving Programme for Family Caregivers of Persons With Dementia: A Randomized Controlled Trial
Status: UNKNOWN
Conditions: Caregiver Burden
Interventions: BEHAVIORAL: The Hybrid Mindfulness-based Dementia caregiving program (MBDCP)|BEHAVIORAL: Psychoeducation educational program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Olaparib and Durvalumab (MEDI4736) in Patients With Metastatic Pancreatic Cancer and DNA Damage Repair Genes Alterations
Status: RECRUITING
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: olaparib+durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of Vaccination With 2009 H1N1 Vaccines During Influenza Season 2010-11
Status: COMPLETED
Conditions: Influenza Caused by the 2009 H1N1 Influenza Virus
Interventions: OTHER: Follow-up|OTHER: Follow-up
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MASTER II - Microvolt T Wave Alternans Testing for Risk Stratification of Post MI Patients
Status: COMPLETED
Conditions: Myocardial Infarction|Arrhythmia, Ventricular|Ischemic Cardiomyopathy
Interventions: PROCEDURE: T Wave Alternans Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Hot and Cold Water Application on Pregnant Women With Restless Leg Syndrome
Status: UNKNOWN
Conditions: Restless Legs Syndrome|Pregnant|Sleep Disorder
Interventions: OTHER: Hot Water Application|OTHER: Cold Water Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Multicenter Prospective Study to Assess the Effects of Adjuvant Icotinib in EGFRm Stage I NSCLC With High-risk of Disease Recurrence After Complete Resection
Status: NOT_YET_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Icotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Aclidinium Bromide and Formoterol Fumarate in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
Status: TERMINATED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Once-daily aclidinium/formoterol|DRUG: Twice-daily formoterol fumarate|DRUG: Placebo to formoterol fumarate|DRUG: Once-daily formoterol fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SAD/MAD Safety and PK Study of QPX9003 (Novel Polymyxin) in Normal Healthy Volunteers
Status: COMPLETED
Conditions: Bacterial Infections
Interventions: DRUG: QPX9003 for IV Infusion|DRUG: Placebo for IV infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SRT for Residual Oligometastases of NSCLC After 3rd Generation EGFR-TKIs
Status: COMPLETED
Conditions: NSCLC Stage IV|EGFR Activating Mutation
Interventions: DRUG: 3rd generation EGFR-TKI|RADIATION: Consolidative SRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Intermediate or Posterior Uveitis
Status: COMPLETED
Conditions: Intermediate Uveitis|Posterior Uveitis
Interventions: DRUG: Dexamethasone|DRUG: dexamethasone|DRUG: Sham injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine/Cisplatin +/-Cetuximab in Patients With Locally Advanced or Metastatic EGFR-Positive Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: GENETIC: cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of the Dietary Supplement CardioFlex Q10 on Reducing Cardiovascular Disease Risk Factors in Adults
Status: COMPLETED
Conditions: Cardiovascular Diseases|Cardiovascular Abnormalities|Heart Attack|Stroke|Hypertension
Interventions: DIETARY_SUPPLEMENT: CardioFlex Q10|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Vanderbilt University Spasticity Management Program Evaluation Plan
Status: COMPLETED
Conditions: Spasticity
Interventions: DRUG: Botulinum Toxin Type A|DRUG: Intrathecal baclofen administered by the Medtronic SyncroMed(TM) pump (ITB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy and Cost-efficacy of Ranibizumab (Monotherapy or Combination With Laser) in the Treatment of Diabetic Macular Edema (DME)
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: ranibizumab|PROCEDURE: Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pecto-intercostal Fascial Block (PIFB) for Postop Analgesia Following Sternotomy in Cardiac Surgery Patients
Status: COMPLETED
Conditions: Analgesia|Sternotomy
Interventions: DRUG: Pecto-intercostal Fascial Block (PIFB)|DRUG: PIFB with adjuvants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Liver Transplant Recipients With Additional 12-month Follow-up and Long-term Extension
Status: TERMINATED
Conditions: Liver Transplant Rejection
Interventions: BIOLOGICAL: CFZ533|DRUG: Tacrolimus - MMF - corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Outcomes Following Total Laparoscopic Hysterectomy and Laparoscopic Supracervical Hysterectomy
Status: UNKNOWN
Conditions: Total Laparoscopic Hysterectomy|Laparoscopic Supracervical Hysterectomy|Fibromas|Abnormal Uterine Bleeding|Dysmenorrhea
Interventions: PROCEDURE: TLH|PROCEDURE: Laparoscopic supracervical hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Zinc and Selenium Supplementation on HIV+ Individuals on Antiretroviral Treatment.
Status: UNKNOWN
Conditions: HIV|ART|Zinc Deficiency|Selenium Deficiency|Metabolic Complication|Inflammation
Interventions: DIETARY_SUPPLEMENT: Zinc gluconate and/or Selenium yeast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Non Carbonic Buffer Power of Critical Ill Patients With Sepsis
Status: COMPLETED
Conditions: Acid-Base Imbalance|Respiratory Acidosis|Respiratory Alkalosis
Interventions: DIAGNOSTIC_TEST: In vitro determination of non-carbonic buffer power|DIAGNOSTIC_TEST: Classic description of acid-base status
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial of Novaferon in Asymptomatic or Mild COVID-19 Patients
Status: UNKNOWN
Conditions: SARS-CoV2 Infection
Interventions: DRUG: Recombinant cytokine gene derived protein injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Botulinum Toxin Injection After Hemorrhoidectomy in Pain Control.
Status: COMPLETED
Conditions: Pain|Haemorriodectomy|Anal Sphincterotomy
Interventions: PROCEDURE: Botox Injectable Product|PROCEDURE: Internal sphincterotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Outcomes of Optometrist Performed Selective Laser Trabeculoplasty (SLT)
Status: UNKNOWN
Conditions: Primary Open-Angle Glaucoma, Unspecified Eye|Ocular Hypertension
Interventions: DEVICE: Selective Laser Trabeculoplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Early Pharmacological Treatment of Acute Spasticity After Spinal Cord Injury
Status: NOT_YET_RECRUITING
Conditions: Traumatic Spinal Cord Injury
Interventions: DRUG: Early baclofen Intervention|DRUG: Usual routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anticoagulation With Enhanced Gastrointestinal Safety
Status: COMPLETED
Conditions: Upper Gastrointestinal Bleeding|Peptic Ulcer Hemorrhage|Anticoagulant-induced Bleeding
Interventions: BEHAVIORAL: Clinician Notification with Nurse Facilitation (CNNF)|BEHAVIORAL: Wait list control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy of Linaclotide in Patients With Chronic Constipation and Prominent Abdominal Bloating
Status: COMPLETED
Conditions: Chronic Constipation|Constipation
Interventions: DRUG: Linaclotide 290 micrograms|DRUG: Linaclotide 145 micrograms|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Three-arm Study to Assess Efficacy and Safety of Ianalumab (VAY736) in Patients With Active Sjogren's Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Sjogren Syndrome
Interventions: BIOLOGICAL: VAY736|BIOLOGICAL: VAY736|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interactions Between Antiretrovirals (ARVs) and Combined Oral Contraceptives (COCs)
Status: COMPLETED
Conditions: HIV/AIDS|HIV Infections
Interventions: DRUG: ETHINYL ESTRADIOL AND LEVOGESTREL|DRUG: ETHINYL ESTRADIOL AND LEVOGESTREL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase 3 Study of Tavocept Versus Placebo in Patients With Newly Diagnosed or Relapsed Advanced Primary Adenocarcinoma of the Lung Treated With Docetaxel or Paclitaxel Plus Cisplatin
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Tavocept(BNP7787) in combination with cisplatin and either docetaxel or paclitaxel|DRUG: Placebo in combination with cisplatin and docetaxel or paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Local Vibration and Cervical Stabilization Exercises Applied on Neck Muscles on Balance in Healthy Individuals
Status: COMPLETED
Conditions: Cervical Pain|Somatosensory Disorders|Vestibular Diseases
Interventions: DEVICE: Neck Muscle Vibration|BEHAVIORAL: Cervical Stabilization Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of BKM120 in Relapsed and Refractory NHL
Status: COMPLETED
Conditions: Diffuse Large B-cell Lymphoma, Mantle Cell Lymphoma, Follicular Lymphoma
Interventions: DRUG: Buparlisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug-coated Balloon for Takayasu Arteritis Associated Renal Artery Stenosis
Status: UNKNOWN
Conditions: Takayasu Arteritis
Interventions: PROCEDURE: Drug coated balloon (DCB)|PROCEDURE: Digital substraction angiography (DSA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Glycemic Effects of Morning Only, Evening Only or Twice Daily Insulin Glargine in Patients With Type 1 Diabetes
Status: TERMINATED
Conditions: Type 1 Diabetes|Hypoglycemia
Interventions: DRUG: Evening only administration of insulin glargine|DRUG: Morning only administration of insulin glargine|DRUG: split dose insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RAFT-P&A Randomized Control Trial
Status: RECRUITING
Conditions: Atrial Fibrillation|Heart Failure|Pacemaker|Arrhythmia Atrial
Interventions: DEVICE: Pace and Ablate|DRUG: Medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Efficacy of Revita® DMR on Body Weight Maintenance in Subjects With Obesity Who Have Achieved at Least 15% Weight Loss on Tirzepatide
Status: NOT_YET_RECRUITING
Conditions: Obesity|Weight Change Trajectory|Weight Change, Body
Interventions: DEVICE: Revita Duodenal Mucosal Resurfacing (DMR)|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Neuromuscular Electrical Stimulation in Patients With Congestive Heart Failure
Status: UNKNOWN
Conditions: Heart Failure
Interventions: DEVICE: stimulation wave (2.5 kHz, burst at 50Hz, on/off: 3/9 sec),|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dihydroartemisinin-piperaquine and Primaquine for Uncomplicated Plasmodium Falciparum Cases
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: dihydroartemisinin-piperaquine|DRUG: dihydroartemisinin-piperaquine + primaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION