pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluate Safety and Effectiveness of XenoSure® Biological Patch in the Application of Peripheral Vascular Repair
Status: ACTIVE_NOT_RECRUITING
Conditions: Vascular Diseases
Interventions: DEVICE: Implant the XenoSure patch|PROCEDURE: Repair/reconstruction of the diseased vessel|DEVICE: Implant the Vascular-Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sintilimab for the Treatment of Locally Advanced, Metastatic, Recurrent, or Unresectable Undifferentiated Pleomorphic Sarcoma, SiARa Cancer Study
Status: TERMINATED
Conditions: Locally Advanced Undifferentiated Pleomorphic Sarcoma|Metastatic Undifferentiated Pleomorphic Sarcoma|Recurrent Undifferentiated Pleomorphic Sarcoma|Unresectable Undifferentiated Pleomorphic Sarcoma
Interventions: BIOLOGICAL: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Canagliflozin With Gemcitabine in Pancreatic Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Canagliflozin and Gemcitabine|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Determine the Safety and Efficacy of an Oral Probiotic Supplementation to Improve Bacterial Vaginosis in Females
Status: NOT_YET_RECRUITING
Conditions: Bacterial Vaginosis
Interventions: OTHER: MetSheFlora - Vaginal Health
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Exploratory Study to Evaluate the Safety and Efficacy of Telbivudine in the Fifth Year of Treatment in Chinese Patients With Compensated Chronic Hepatitis B
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Telbivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment of Perfusion Techniques During Repair of Coarctation With Aortic Arch Hypoplasia in Infants
Status: UNKNOWN
Conditions: Coarctation of Aorta
Interventions: PROCEDURE: Surgical repair of coarctation of aorta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 8-Chloro-Adenosine in Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia|Chronic Lymphocytic Leukemia
Interventions: DRUG: 8-Chloro-Adenosine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: N-of-1 Trials In Children With Hypertension
Status: COMPLETED
Conditions: Pediatric Hypertension
Interventions: OTHER: NICHE method|OTHER: Usual care|DRUG: Amlodipine|DRUG: Lisinopril|DRUG: Hydrochlorothiazide|DRUG: Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Open and Laparoscopic Abdominal Surgery Involving the Intestinal Tract on Serum 1,3-ß-D-Glucan (BDG) Values
Status: COMPLETED
Conditions: Invasive Candidiases
Interventions: DIAGNOSTIC_TEST: Beta D Glucan test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Metformin and Pioglitazone Effects on Fetuin-A and Osteoprotegrin Concentrations in Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Metformin|DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Anterior Vs Posterior Procedures for Cervical Spondylotic Myelopathy: Prospective Randomized Clinical Trial
Status: UNKNOWN
Conditions: Cervical Spondylotic Myelopathy
Interventions: PROCEDURE: ACDF|PROCEDURE: Cervical laminoplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Feasibility Study of mFOLFOX6 in Patients With Advanced Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: Oxaliplatin|DRUG: l-Leucovorin|DRUG: 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the KeraKlear Keratoprosthesis in Patients With Corneal Opacity
Status: TERMINATED
Conditions: Corneal Blindness
Interventions: DEVICE: KeraKlear Non-Penetrating Keratoprosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D3 and Omega-3FA on Leptin and HbA1C With Vitamin D Deficiency
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: VD3 group|DIETARY_SUPPLEMENT: omega 3 FA group|DIETARY_SUPPLEMENT: VD3 and omega- 3FA group|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Comparative Effectiveness RCT of Optimized Cessation Treatments
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Nicotine patch|BEHAVIORAL: in-person counseling and quitline counseling|DRUG: Preparation Nicotine Mini-Lozenges|DRUG: Combination NRT (nicotine patch + nicotine mini-lozenges)|BEHAVIORAL: Intensive In-Person Cessation Counseling|BEHAVIORAL: Extended Maintenance Counseling Calls|BEHAVIORAL: Automated Adherence Calls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Emotional Processing and Oxytocin Mechanisms in Premenstrual Dysphoric Disorder: A Pilot Study
Status: COMPLETED
Conditions: Premenstrual Dysphoric Disorder
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: High Level Pulsed Heat Versus Low Level Steady Heat in Subjects With Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Pain|Low Back Pain|Heat|Analgesia
Interventions: DEVICE: High Level Pulsed Heat delivered by Generation 5 devices from Soovu Labs Inc.|DEVICE: Low Level (37 degrees C) delivered by the control device Generation 5 devices from Soovu Labs Inc.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effect of Craniocervical Flexion Training on Suprahyoid Muscles in Healthy Individuals
Status: COMPLETED
Conditions: Dysphagia|Rehabilitation|Stability
Interventions: BEHAVIORAL: Exercises Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: the Effect of Different Mechanical Ventilation Modes on Optic Nerve Diameter and Conscious Functions
Status: COMPLETED
Conditions: Mechanical Ventilation
Interventions: PROCEDURE: The Effect of Different Mechanical Ventilator Modes on Optic Nerve Diameter and Cognitive Functions in Laporoscopic Cholecystectomy Operations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Efficiency and Economic Impact of LC-OCT (Line-field Confocal Optical Coherence Tomography) for the Diagnosis and Management of Basal Cell Carcinomas
Status: NOT_YET_RECRUITING
Conditions: Basal Cell Carcinoma of the Skin
Interventions: DIAGNOSTIC_TEST: diagnosis based on deepLive™ LC-OCT device|DIAGNOSTIC_TEST: diagnosis based on skin biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Open-Label Study Of Exemestane With Or Without Celecoxib In Postmenopausal Women With ABC Having Progressed On Tamoxifen
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Exemestane|DRUG: Celecoxib + Exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double Blinded Randomized Trial Between Lidocaine And Plain Gel For Urethral Straight Catheterization And The Q-Tip Test
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: 2% Lidocaine jelly|DRUG: Plain aqueous gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence Study for Donepezil Hydrochloride 10 mg Tablets Under Fasting Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Donepezil Hydrochloride|DRUG: Aricept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Web-Based Dyadic Intervention for Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Carcinoma
Interventions: OTHER: Internet-Based Intervention|OTHER: Interview|OTHER: Survey Administration|OTHER: Electronic Health Record Review
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Caffeine in the Second Stage of Labor in Low-risk Nulliparous Mothers at Term
Status: NOT_YET_RECRUITING
Conditions: Second Stage of Labor
Interventions: DRUG: Caffeine and Sodium Benzoate Injection|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Nortriptyline on Abdominal Pain/Discomfort and Quality of Life in Patients With Nonulcer Dyspepsia
Status: TERMINATED
Conditions: Non Ulcer Dyspepsia
Interventions: DRUG: Nortriptyline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Serotonergic Modulation on Intestinal Permeability and Visceral Hypersensitivity in Healthy Individuals and Irritable Bowel Syndrome (IBS) Patients
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Oxitriptan|OTHER: Acute tryptophan depletion|OTHER: Amino acid drink with tryptophan|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of an Evidence-based Physiotherapy Regimen for Patients With Rotator Cuff Tendinopathy
Status: UNKNOWN
Conditions: Tendinopathy|Shoulder Impingement Syndrome|Shoulder Pain|Subacromial Impingement
Interventions: OTHER: Structured Physiotherapy Regimen|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Adipose Tissue-derived Mesenchymal Stem Cells in Ischemic Stroke
Status: UNKNOWN
Conditions: Ischemic Stroke|Adipose Tissue-derived Stem Cell|Functional Status
Interventions: OTHER: Alogenic adipose tissue-derived stem cells|DRUG: Placebo solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lusedra (Fospropofol Disodium) for Minimal to Moderate Sedation for Regional Anesthesia Block Prior to Orthopedic Surgery
Status: TERMINATED
Conditions: Procedural Sedation|Regional Anesthesia Block|Orthopedic Surgery
Interventions: DRUG: Fospropofol disodium|DRUG: Fospropofol disodium|DRUG: Placebo + Midazolam|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nerve Block Under Ultrasound on Postoperative Prognosis in Children
Status: COMPLETED
Conditions: Quality of Recovery
Interventions: PROCEDURE: Ultrasound-guided lower abdominis rectus sheath block|PROCEDURE: Local anesthesia infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SkinTE® for the Treatment of Wagner 1 Diabetic Foot Ulcers (COVER DFUS II)
Status: NOT_YET_RECRUITING
Conditions: Diabetic Foot
Interventions: BIOLOGICAL: SkinTE|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protecting Our Community: COVID-19 Testing
Status: COMPLETED
Conditions: SARS-CoV-2|Covid19
Interventions: DIAGNOSTIC_TEST: Home-based SARS-CoV-2 test kit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A 6 Week Study to Determine the Effectiveness of R228060 in Adult Subjects With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: R228060|DRUG: Placebo and Paroxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Recombinant BNP on Heart and Renal Function in Acute Heart Failure
Status: UNKNOWN
Conditions: Acute Heart Failure|Acute Renal Failure
Interventions: DRUG: rhBNP|DRUG: standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome
Status: COMPLETED
Conditions: Pleuropulmonary Blastoma|Cystic Nephroma|Sertoli-Leydig Cell Tumor of Ovary|Medulloepithelioma|Embryonal Rhabdomyosarcoma of Cervix|Goiter|Sarcoma|Pineoblastoma|Pituitary Tumors|Wilms Tumor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of SAF312 in Patients With Neurogenic Detrusor Overactivity Due to Spinal Cord Lesions
Status: TERMINATED
Conditions: Neurogenic Urinary Bladder|Neurogenic Bladder Disorder|Neurogenic Dysfunction of the Urinary Bladder|Neurogenic Bladder, Uninhibited|Neurogenic Bladder, Spastic
Interventions: DRUG: SAF312|DRUG: Placebo to SAF312
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Adults to Assess Priming With Antigenically Mismatched Live Attenuated A/H7N3 Influenza Virus Vaccine Followed by Inactivated A/H7N9 Influenza Virus Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: H7N3 pLAIV|BIOLOGICAL: H7N9 pIIV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Simvastatin and Micronized Trans-resveratrol Treatment on Polycystic Ovary Syndrome (PCOS) Patients
Status: UNKNOWN
Conditions: PCOS, Insulin Resistance
Interventions: DRUG: Simvastatin and micronized trans-resveratrol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Clinical Trial of Diphtheria, Tetanus and Acellular Pertussis (Three Components) Combined Vaccine, Adsorbed .
Status: COMPLETED
Conditions: Diphtheria|Tetanus|Pertussis
Interventions: BIOLOGICAL: Diphtheria,Tetanus and Acellular Pertussis (Three Components) Combined Vaccine, Adsorbed|BIOLOGICAL: Diphtheria and Tetanus Combined Vaccine, Adsorbed|BIOLOGICAL: Diphtheria-tetanus-acellular pertussis vaccine|BIOLOGICAL: Diphtheria,tetanus,pertussis(acellular,component),poliomyelitis(inactivated) vaccine(absorbed) and Haemophilus influenzae type b conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Mirror Therapy and Modified Constrain Induced Movement Therapy on Risk of Fall, Balance and Gait in Stroke
Status: RECRUITING
Conditions: Stroke
Interventions: OTHER: CIMT Group|OTHER: Mirror Therapy group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of 2 Depth of Sedation Indices in the Intensive Care Unit
Status: COMPLETED
Conditions: RASS-score|Deep Sedation|Post-cardiac Surgery
Interventions: DEVICE: Neurowave and Sedline indices in view
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Controlled Human Malaria Infection by Intradermal Injection of Plasmodium Falciparum Sporozoites in Tanzanian Adults
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: PfSPZ Challenge|BIOLOGICAL: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Gene-Environment Interaction and Precision Nutrition on Adiposity, Glycemic, Lipids Changes, and Bone Health
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: OTHER: Preventing Overweight Using Novel Dietary Strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety of BB-12 Supplemented Strawberry Yogurt For Healthy Adults on Antibiotics
Status: COMPLETED
Conditions: Adults on Antibiotics
Interventions: DRUG: Bifidobacterium animalis subsp. lactis strain BB-12|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optimization of Ventilator Setting for Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Acute Exacerbation of Chronic Obstructive Airways Disease
Interventions: PROCEDURE: Optimized ventilation|PROCEDURE: Standard ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Selinexor in Myelofibrosis Refractory or Intolerant to JAK1/2 Inhibitors
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Myelofibrosis|Post-essential Thrombocythemia Myelofibrosis|Post-polycythemia Vera Myelofibrosis
Interventions: DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Success of Zirconia and Composite Strip Crowns for Primary Incisors
Status: COMPLETED
Conditions: Dental Caries in Children
Interventions: DEVICE: Zirconia crown|DEVICE: composite strip crown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Preventing Sexual Dysfunction With Aromatase Inhibitors
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Questionnaires|OTHER: Education Materials|OTHER: Luvena|OTHER: Hyalo-Gyn|OTHER: Vaginal Lubricant|BEHAVIORAL: Interactive Internet-Based Website|BEHAVIORAL: Telephone Counseling.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety, Immunogenicity, and Prevention of TB With AERAS-404 and BCG Revaccination in Healthy Adolescents
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: AERAS-404|DRUG: Placebo|BIOLOGICAL: Bacillus Calmette-Guérin (BCG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Continuous Delivery Room Skin-to-skin-study for Moderate and Late Preterm Infants
Status: RECRUITING
Conditions: Preterm Birth|Mother-Infant Interaction|Infant Development
Interventions: PROCEDURE: skin-to-skin contact
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy Plus Drug Treatment for Obsessive Compulsive Disorder
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: BEHAVIORAL: Exposure and Ritual Prevention (Cognitive Behavioral Therapy)|BEHAVIORAL: Stress Management Therapy (Cognitive Behavior Therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Accelerated Healing and Anti-scarring Potential of Avotermin (Juvista) in Split Skin Graft Donor Sites
Status: COMPLETED
Conditions: Cicatrix|Wound Healing
Interventions: DRUG: Avotermin|DRUG: Placebo|DRUG: Avotermin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NEXAGON for the Treatment of Corneal Persistent Epithelial Defects Following Severe Ocular Chemical and/or Thermal Injuries
Status: UNKNOWN
Conditions: Corneal Persistent Epithelial Defect
Interventions: DRUG: Nexagon® (lufepirsen) High Dose Concentration|DRUG: Nexagon® (lufepirsen) Low Dose Concentration|DRUG: Vehicle|DRUG: Open-label Nexagon® (lufepirsen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Beta Blocker Treatment on Endothelial Function in Patients With Type 2 Diabetes or Chronic Heart Failure
Status: COMPLETED
Conditions: Endothelial Function|Beta Blocker
Interventions: DRUG: Treatment with either metoprolol or carvedilol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Breast Cancer Outreach Among Primary Care Patients
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Bulk Order|BEHAVIORAL: Texting|BEHAVIORAL: Clinician Endorsement|BEHAVIORAL: No Bulk Order|BEHAVIORAL: Standard Endorsement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Lapatinib Ditosylate and Radiation Therapy in Treating Patients With Locally Advanced or Locally Recurrent Breast Cancer
Status: TERMINATED
Conditions: Male Breast Cancer|Recurrent Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: DRUG: lapatinib ditosylate|RADIATION: radiation therapy|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Short Term Open, Randomized Cross-over Trial Exploring the Effect of Carbonic Anhydrase Inhibition by Acetazolamide on Sleep Apnea Associated Hypertension and Vascular Dysfunction
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Sleep-Disordered Breathing|Blood Pressure|Hypertension
Interventions: DRUG: Acetazolamide|DEVICE: nasal Continuous Positive Airway Pressure (nCPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lactobacillus Reuteri for Non-surgical Periodontal Treatment of Chronic Periodontitis With Type 2 Diabetes Patients
Status: NOT_YET_RECRUITING
Conditions: Periodontitis
Interventions: DIETARY_SUPPLEMENT: Probiotics|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Lotus Valve For TAVI In Patients With Severe Aortic Stenosis In Chinese Population
Status: UNKNOWN
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: Lotus Valve System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Walnut Intake on Vascular Function and Metabolism
Status: COMPLETED
Conditions: Overweight and Obesity|Endothelial Dysfunction|Cardiovascular Risk Factor
Interventions: OTHER: Walnut Intake
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Factors in Accuracy Studies Influencing Measured CGM Performance.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DEVICE: Arterialized-venous reference (YSI)|DEVICE: Venous reference measurement (YSI)|DEVICE: Capillary reference (SMBG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cholecalciferol(25-[OH]-Vitamin D) in Treating Patients With Colorectal Cancer
Status: WITHDRAWN
Conditions: Mucinous Adenocarcinoma of the Colon|Mucinous Adenocarcinoma of the Rectum|Signet Ring Adenocarcinoma of the Colon|Signet Ring Adenocarcinoma of the Rectum|Stage I Colon Cancer|Stage I Rectal Cancer
Interventions: DIETARY_SUPPLEMENT: cholecalciferol|PROCEDURE: biopsy|GENETIC: protein expression analysis|OTHER: enzyme-linked immunosorbent assay|OTHER: laboratory biomarker analysis|GENETIC: reverse transcriptase-polymerase chain reaction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study of GR1802 in Patients With Chronic Rhinosinusitis With Nasal Polyps
Status: RECRUITING
Conditions: Chronic Rhinosinusitis With Nasal Polyps
Interventions: BIOLOGICAL: GR1802 injection|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Extracorporeal Cardiac Shock Wave Therapy in Patients With Ischemia-reperfusion Injury
Status: NOT_YET_RECRUITING
Conditions: Myocardial Reperfusion Injury|Treatment Outcome|Prognosis|ST Elevation Myocardial Infarction
Interventions: DEVICE: Extracorporeal cardiac shock wave therapy(ECSW)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dynamic Electrostimulation on the Abdominal Muscles in Healthy Individuals
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: WB-EMS (Whole body electrostimulation)|DEVICE: EMS|DEVICE: WB-EMS off
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of Digital Versus Conventional Techniques for Construction of Mandibular Implant Retained Overdenture
Status: COMPLETED
Conditions: Occlusal Wear of Teeth
Interventions: DEVICE: 3d Printed implant|DEVICE: Conventionally constructed implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Progel Vascular Sealant
Status: COMPLETED
Conditions: Aortic Valve Stenosis|Aneurysm of Ascending Aorta|Aortic Valve Disorder|Bicuspid Valve Disorder
Interventions: DEVICE: Progel Vascular Sealant|DEVICE: Gelfoam Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: UNITE Study: Understanding New Interventions With GBM ThErapy
Status: TERMINATED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Steroid eye drops|DRUG: Vasoconstrictor eye drops|OTHER: Cold compress|DRUG: Ophthalmic steroid ointment|DRUG: Depatuxizumab mafodotin|DRUG: Temozolomide|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In-vivo Efficacy of Patient Preoperative Prep, ZuraPrep (ZP)
Status: COMPLETED
Conditions: Surgical Skin Preparation
Interventions: DRUG: ZuraPrep Clear Solution|DRUG: ChloraPrep|DRUG: ZuraPrep Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Psilocybin-Assisted Cognitive Processing Therapy for Chronic PTSD
Status: NOT_YET_RECRUITING
Conditions: Post Traumatic Stress Disorder|PTSD|Chronic PTSD
Interventions: DRUG: Psilocybin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Simethicone on Bowel Preparation for Colonoscopy
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: PEG-Asc|DRUG: PEG-Asc with simethicone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Rate Control in Atrial Fibrillation
Status: COMPLETED
Conditions: Rapid Ventricular Response Atrial Fibrillation
Interventions: DRUG: Propranolol|DRUG: Metoprolol|DRUG: Verapamil|DRUG: Diltiazem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Gelfoam to Prevent Pneumothorax After Lung Biopsy
Status: WITHDRAWN
Conditions: Pneumothorax Iatrogenic Postprocedural
Interventions: BIOLOGICAL: Gelfoam slurry|PROCEDURE: CT-guided percutaneous lung biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Tipifarnib as Postconsolidation Therapy for Acute Myeloid Leukemia in Patients 60 Years and Older
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: ZARNESTRA, tipifarnib, R115777
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GLPG0259 Multiple Ascending Dose and Methotrexate Drug-drug Interaction (DDI) in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: placebo|DRUG: GLPG0259|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Study of Head and Neck MRI and Tumor Microenvironment Biomarkers
Status: NOT_YET_RECRUITING
Conditions: Squamous Cell Carcinoma of Head and Neck
Interventions: RADIATION: Standard of care external beam radiotherapy (single integrated boost)|RADIATION: Standard of care external beam radiotherapy (two-phase treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploring the Safety and Effectiveness of Toripalimab Combined With Neoadjuvant Radiotherapy and Chemotherapy in the Locally Advanced Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Locally Advanced Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Toripalimab+Nedaplatin+Albumin Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perfusion Assessment of Wound Closure Techniques in Primary Total Knee Arthroplasty
Status: COMPLETED
Conditions: Total Knee Arthroplasty
Interventions: PROCEDURE: Staple Closure|PROCEDURE: Vertical Mattress Closure|PROCEDURE: Running Subcuticular Closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Imprime PGG and Pembrolizumab in Advanced Melanoma and Triple Negative Breast Cancer
Status: COMPLETED
Conditions: Advanced Melanoma|Triple-Negative Breast Cancer
Interventions: BIOLOGICAL: Imprime PGG|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Safety and Feasibility of AAV1/SERCA2a Gene Transfer in Patients With Chronic Heart Failure
Status: TERMINATED
Conditions: Chronic Heart Failure|Patients That Have Received a Left Ventricular Assist Device
Interventions: GENETIC: AAV1/SERCA2a|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tinzaparin for Primary Treatment and Extended Secondary Prophylaxis of Venous Thromboembolism in Patients With Cancer
Status: TERMINATED
Conditions: Venous Thromboembolism|Cancer
Interventions: DRUG: Tinzaparin sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Investigation of the Gut Microbiome and Statin Response
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: Rosuvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety of Prodencel in the Treatment of Metastatic Castration-resistant Prostate Cancer (mCRPC)
Status: UNKNOWN
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: BIOLOGICAL: Prodencel; an autologous dendritic cell therapeutic tumor vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicentric Prospective Study to Screen Inborn Errors of Metabolism in Non-immune Hydrops (NIH) Fetalis by Massively Parallel Sequencing
Status: RECRUITING
Conditions: Non-Immune Hydrops Fetalis
Interventions: DIAGNOSTIC_TEST: NON-IMMUNE HYDROPS FETALIS diagnosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Inclisiran as Monotherapy in Chinese Adults With Low or Moderate ASCVD Risk and Elevated Low-density Lipoprotein Cholesterol.
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Hypercholesterolemia or Mixed Dyslipidemia
Interventions: DRUG: Inclisiran|DRUG: Matching Placebo for Inclisiran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Persistence of Hepatitis B Vaccination in HIV-Infected Patients
Status: UNKNOWN
Conditions: Hepatitis B Vaccine
Interventions: BIOLOGICAL: 20 µg recombinant hepatitis B vaccine at months 0, 1, and 6|BIOLOGICAL: 20 µg recombinant hepatitis B vaccine at months 0, 1, 2, and 6|BIOLOGICAL: 60 µg recombinant hepatitis B vaccine at months 0, 1, 2, and 6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Music Therapy for Persons With Dementia
Status: COMPLETED
Conditions: Quality of Life|Social Interaction|Emotions|Mood|Feelings|Alzheimer Disease|Dementia
Interventions: BEHAVIORAL: Music therapy|BEHAVIORAL: Non-Music Verbal Interaction (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimization of Synvisc-One for Knee OA
Status: TERMINATED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Synvisc-One Injection|OTHER: Sham Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Doxorubicin and Cyclophosphamide in Treating Older Women With Stage I, Stage II, or Stage III Breast Cancer That Has Been Removed By Surgery
Status: COMPLETED
Conditions: Breast Cancer|Cognitive/Functional Effects|Depression|Malnutrition|Psychosocial Effects of Cancer and Its Treatment
Interventions: DRUG: AC regimen|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|PROCEDURE: adjuvant therapy|PROCEDURE: cognitive assessment|PROCEDURE: management of therapy complications|PROCEDURE: psychosocial assessment and care|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tocilizumab With or Without Methotrexate in Patients With Rheumatoid Arthritis.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: tocilizumab [RoActemra/Actemra]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Popliteal Plexus Block on Pain After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Popliteal Plexus Block|Total Knee Arthroplasty
Interventions: DRUG: Bupivacaine-epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Safety and Efficacy of Amlodipine Verses S Amlodipine in Patients With Essential Hypertension
Status: UNKNOWN
Conditions: Essential Hypertension
Interventions: DRUG: S-amlodipine 2.5mg|DRUG: Amlodipine 5mg
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of JM-010 in PD With Levodopa-Induced Dyskinesia
Status: COMPLETED
Conditions: Parkinson's Disease|Levodopa Induced Dyskinesia (LID)
Interventions: DRUG: JM-010|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alpelisib and Capecitabine in Patients With PIK3CA Mutant mCRC Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Colorectal Cancer|PIK3CA Gene Mutation
Interventions: DRUG: Alpelisib plus Capecitabine combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Mesalazine Combined With Biologics in the Treatment of Moderate to Severe Ulcerative Colitis
Status: RECRUITING
Conditions: Ulcerative Colitis|Efficacy, Self|Biologics|Mesalazine
Interventions: DRUG: Infliximab|DRUG: Vedolizumab|DRUG: Mesalazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Arm Trial Evaluating the BARD Lutonix Drug-Coated Balloon (LTX DCB) for Treatment of Femoropopliteal Arteries
Status: COMPLETED
Conditions: Femoral Artery Stenosis|Femoral Artery Occlusion|Stenosis of Popliteal Arteries|Occlusion of Popliteal Arteries
Interventions: DEVICE: LTX DCB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EPR Tumor Oximetry With CE India Ink
Status: TERMINATED
Conditions: Neoplasms, Malignant|Breast Neoplasm|Carcinoma, Basal Cell|Carcinoma, Squamous Cell|Melanoma|Skin Neoplasm|Head and Neck Neoplasms
Interventions: DEVICE: Carlo Erba Ink Injection|OTHER: EPR Oximetry Measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pembrolizumab Alone and In Combination With Acalabrutinib (ACP-196) in Subjects With Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Pembrolizumab|DRUG: Acalabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TMC125-C227: A Phase II Randomized, Active-Controlled, Open Label Trial to Investigate the Efficacy and Tolerability of TMC125 in HIV-1 Infected Subjects, Who Are PI-Naive and With Documented Genotypic Evidence of NNRTI Resistance From Previous NNRTI Use
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: TMC125
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine and Pemetrexed in Primary Unknown Adenocarcinoma
Status: COMPLETED
Conditions: Adenocarcinoma
Interventions: DRUG: Pemetrexed|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy And Safety Of Sofosbuvir/Velpatasvir Fixed Dose Combination With Ribavirin in Chronic HCV Infected Adults Who Participated in a Prior Gilead Sponsored HCV Treatment Study
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: SOF/VEL|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: York Study of Unloading Shoes for Vascular Intermittent Claudication
Status: COMPLETED
Conditions: Intermittent Claudication|Peripheral Arterial Disease
Interventions: DEVICE: Unloading shoes|DEVICE: Unadapted control shoe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Dexamethasone vs Bevacizumab in Aboriginal People With DMO
Status: COMPLETED
Conditions: Diabetic Macular Edema|Diabetic Retinopathy
Interventions: DRUG: Dexamethasone intravitreal implant|DRUG: Bevacizumab Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quality Control of CE-Certified Phonak Hearing Aids - 2017_27
Status: COMPLETED
Conditions: Hearing Loss, Bilateral Sensorineural, Progressive
Interventions: DEVICE: Line extension of the Phonak Audéo B product family
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase I Clinical Study of Recombinant Humanized Anti-CD20(B-lymphocyte Antigen CD20) Monoclonal Antibody Subcutaneous Injection in the Treatment of Primary Membranous Nephropathy
Status: RECRUITING
Conditions: Primary Membranous Nephropathy
Interventions: DRUG: B007|DRUG: B007|DRUG: B007
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Laser-assisted Flapless Corticotomy in Accelerating Canine Retraction
Status: COMPLETED
Conditions: Class II Division 1 Malocclusion|Maxillary Prognathism|Protrusion, Incisor
Interventions: PROCEDURE: Er:YAG laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Daylight-PDT for AKs: Comparing Two Photosensitizers (BF-200 ALA and MAL)
Status: COMPLETED
Conditions: Multiple Actinic Keratoses
Interventions: DRUG: BF-200 ALA cream|DRUG: MAL cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Bisphosphonate Therapy (Zoledronic Acid) in Patients With Malignant Mesothelioma (UAB 0901)
Status: COMPLETED
Conditions: Mesothelioma
Interventions: DRUG: Zometa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CPG10101 Combination Therapy For The Treatment Of Hepatitis C In Relapsed Hepatitis C Virus (HCV) Subjects
Status: COMPLETED
Conditions: Hepatitis, Chronic Active
Interventions: DRUG: CPG10101|DRUG: CPG10101|DRUG: CPG10101|DRUG: CPG10101|DRUG: Control|DRUG: CPG10101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Using Mask During the 6-minute Walking Test in Times of COVID-19
Status: UNKNOWN
Conditions: Pulmonary Disease|Covid19|Physical Disability
Interventions: OTHER: 6-min-walk surgical mask|OTHER: 6-min-walk Fpp2|OTHER: 6-min-walk without mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: DNA Vaccine Therapy in Treating Patients With Chronic Hepatitis C Virus Infection
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Hepatitis|Hepatitis C Infection
Interventions: BIOLOGICAL: Electroporation-Mediated Plasmid DNA Vaccine Therapy|BIOLOGICAL: HCV DNA Vaccine INO-8000|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment|BIOLOGICAL: Rocakinogene Sifuplasmid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Modified Intermittent Eating on Weight Loss (INTEREST-3 Trial)
Status: RECRUITING
Conditions: Obesity
Interventions: BEHAVIORAL: Intermittent fasting plus time-restricted eating|BEHAVIORAL: Calorie restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Clinical Study of KW-6500 in Parkinson's Disease Patients With Motor Response Complication on Levodopa Therapy
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: apomorphine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Measuring the Glycemic Index and Tracking Metabolites of New and Emerging Lentil Varieties
Status: COMPLETED
Conditions: Hyperglycemia|Dietary Modification
Interventions: OTHER: Lentil Variety|OTHER: White Bread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE