pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Metabolism And Health Effects Of Citrus Limonoids in Hypercholesterolemic Humans
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: Citrus Limonoid Beverage|DIETARY_SUPPLEMENT: Placebo beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: FMT to Convert Response to Immunotherapy
Status: RECRUITING
Conditions: Melanoma Stage III|Melanoma Stage IV
Interventions: OTHER: Fecal microbiota transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Bioquivalence Between a Novel Naproxen Sodium 275 mg Film-coated Tablet and Nalgesin Naproxen Sodium 275 mg Film-coated Tablet in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Naproxen sodium (test product)|DRUG: Naproxen sodium (reference product)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PILI at Work a 5-Year Controlled Intervention Trial: Testing DVD Versus Group Delivery of a Weight-Loss Maintenance Intervention in Native Hawaiian- Serving Worksites
Status: COMPLETED
Conditions: Obesity|Overweight|Weight Loss|Weight Loss Maintenance
Interventions: BEHAVIORAL: Weight loss maintenance intervention face-to-face|BEHAVIORAL: Weight loss maintenance intervention delivered via DVD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Onset and Recovery of Ultrasound Guided Out-of-plane Versus In-plane Interscalene Block in Arthroscopic Shoulder Surgery
Status: COMPLETED
Conditions: Analgesia
Interventions: DRUG: Bupivacaine Hydrochloride in-plane approach for the interscalene block|DRUG: Bupivacaine Hydrochloride out of-plane approach for the interscalene block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Antidote for Valproic Acid Toxicity: a New Indication for Meropenem Antibiotic.
Status: UNKNOWN
Conditions: Drug Toxicity
Interventions: DRUG: Meropenem Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Part II: Exercise in Hispanic Breast Cancer Survivors
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Baseline Fitness Test|BEHAVIORAL: Questionnaires|BEHAVIORAL: Individualized Exercise Program|BEHAVIORAL: Written Materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Technology-assisted Case Management in Adults With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes
Interventions: BEHAVIORAL: Technology-Assisted Case Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Photobiomodulation Therapy in the Prevention and Management of Chemotherapy-Induced Alopecia
Status: RECRUITING
Conditions: Chemotherapy-induced Alopecia
Interventions: DEVICE: Theradome® LH80 pro|DEVICE: Scalp cooling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: [18F]MK-6240 Positron Emission Tomography (PET) Tracer First-in-Human Validation Study (MK-6240-001)
Status: COMPLETED
Conditions: Alzheimer's Disease|Amnestic Mild Cognitive Impairment
Interventions: DRUG: [18F]MK-6240, ~185 MBq|DRUG: [18F]MK-6240, ~160 MBq
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Acetazolamide Efficacy in Ataxia in PMM2-CDG
Status: TERMINATED
Conditions: Pmm2-CDG|CDG1A
Interventions: DRUG: Placebo|DRUG: Acetazolamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Online Training Program With a Clinical Procedure Standardized in Units of Nursing (CPSUN)
Status: COMPLETED
Conditions: Infection Control|Preventive Measures
Interventions: PROCEDURE: Online training of a nursing technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Teleconsultation in Referring a Patient With Early Myocardial Infarction From Peripheral Hospital to Cardiac Centre in Hail, Saudi Arabia
Status: NOT_YET_RECRUITING
Conditions: Telemedicine
Interventions: OTHER: Application of teleconsultation for a patient with a provisional diagnosis of myocardial infarction at the district hospital
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: LSD Treatment for Persons With Alcohol Use Disorder
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use Disorder (AUD)
Interventions: DRUG: LSD|DRUG: Active placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of OASIS Wound Matrix With Approved Dressings for Skin Graft Donor Sites
Status: WITHDRAWN
Conditions: Skin Graft Complications
Interventions: OTHER: Tegaderm™(Absorbant, 3M)|DEVICE: OASIS® wound matrix|OTHER: Xeroform™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Listening Music, Drawing on Coping With Dysmenorrhea Complaints of Nursing Students
Status: COMPLETED
Conditions: Music|Drawing|Coping Behavior|Dysmenorrhea|Symptom, Depressive|Dysmenorrhea Symptom
Interventions: BEHAVIORAL: Music|BEHAVIORAL: Drawing Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Assess the Efficacy and Safety of Treatment With FOLFIRI-aflibercept Compared to Initial Treatment With FOLFIRI-aflibercept (for 6 Cycles) Followed by Maintenance With 5FU-aflibercept, in an Elderly Population With mCRC After Failure of an Oxaliplatin-based Regimen
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Aflibercept|DRUG: Irinotecan|DRUG: folinic acid (dl racemic)|DRUG: 5Fluorouracil|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Specialized Pacing for Patients With Congenital Heart Disease
Status: TERMINATED
Conditions: Congenital Heart Disease|Bradycardia Sinus
Interventions: DEVICE: Closed loop stimulation|DEVICE: Standard rate response
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Postoperative Recovery After Breast Reconstruction With Autologous Tissue (BestDIEP)
Status: RECRUITING
Conditions: Breast Reconstruction|Breast Cancer
Interventions: PROCEDURE: Venous augmentation|PROCEDURE: Traditional ERAS (enhanced recovery after surgery) protocol|PROCEDURE: Sahlgrenska recovery protocol|PROCEDURE: No venous augmentation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy/Safety of Midurethral Sling
Status: RECRUITING
Conditions: Stress Urinary Incontinence
Interventions: PROCEDURE: Urodynamic investigations before and after a trans-obturator tape protocol.|PROCEDURE: Urodynamic investigations before and after a tension-free vaginal tape-obturator (TVT-O)|PROCEDURE: Urodynamic investigations before and after a mini Arc protocol.|PROCEDURE: Urodynamic investigations before and after an i-STOP mini adjustable sling protocol.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study for Use of Menactra® Versus Adacel® in Subjects 11 to 55 Years of Age in South Korea
Status: COMPLETED
Conditions: Meningitis|Meningococcal Disease
Interventions: BIOLOGICAL: Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine (Menactra®)|BIOLOGICAL: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ipilimumab + Androgen Depravation Therapy in Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Ipilimumab|DRUG: Leuprolide|DRUG: Goserelin|DRUG: Degarelix
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Beta-Lactam in Hospitalized Patients With Skin and Skin Structure Infections
Status: COMPLETED
Conditions: Soft Tissue Infections
Interventions: DRUG: Standard care|DRUG: beta-lactam|DRUG: beta-lactam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 28 Day Study of ONO-9054 Ophthalmic Solution in Subjects With Ocular Hypertension (OHT) or Open-angle Glaucoma (OAG)
Status: COMPLETED
Conditions: Ocular Hypertension|Open Angle-glaucoma
Interventions: DRUG: ONO-9054|DRUG: Latanoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Iso-inertial Resistance Training in Physically Active Older Adults
Status: RECRUITING
Conditions: Aged|Muscle Strength|Resistance Training
Interventions: OTHER: Isoinertial training|OTHER: Gravitational training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial of a Transversus Abdominis Plane (TAP) Block in Laparoscopic Colorectal Surgery
Status: COMPLETED
Conditions: Post-operative Pain|Postoperative Nausea|Postoperative Complications
Interventions: DRUG: Levobupivicaine 0.25%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: As Needed Beclomethasone/Salbutamol Combination in Single Inhaler for Mild Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: beclomethasone/salbutamol combination|DRUG: beclomethasone|DRUG: salbutamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Ways of Preventing Patients From Being Awake During High-Risk Surgery and Anesthesia
Status: COMPLETED
Conditions: Explicit Recall of Intra-operative Events
Interventions: DEVICE: BIS Monitor guided algorithm|BEHAVIORAL: Volatile anesthetic guided algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: 6-minute Stepper Test and Pulmonary Rehabilitation in Patients With Severe to Very Severe Chronicle Obstructive Pulmonary Disease
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease|Pulmonary Rehabilitation|6-minute Stepper Test
Interventions: OTHER: 2 times : 6-minute stepper test with a rest of 20min between each test.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mix of Demineralized Freeze-Dried Bone Allograft and Deproteinized Bovine Bone Mineral: a Possible Solution for Alveolar Ridge Preservation?
Status: RECRUITING
Conditions: Alveolar Ridge Preservation|Dental Extraction|Bone Graft
Interventions: PROCEDURE: Alveolar ridge preservation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aurexis® in Cystic Fibrosis Subjects Chronically Colonized With Staphylococcus Aureus in Their Lungs
Status: COMPLETED
Conditions: Staphylococcus Aureus
Interventions: DRUG: Aurexis® (tefibazumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study To Evaluate The Efficacy And Safety Of Ertugliflozin In Participants With Type 2 Diabetes Mellitus And Inadequate Glycemic Control On Metformin Monotherapy (MK-8835-007).
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Ertugliflozin 5 mg|DRUG: Ertugliflozin 15 mg|DRUG: Placebo to Ertugliflozin|OTHER: Glimepiride|DRUG: Placebo to Glimepiride|BIOLOGICAL: Basal Insulin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Rifampicin on the Pharmacokinetics and Pharmacodynamics of Sublingual and Intravenous Buprenorphine
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Placebo|DRUG: Rifampicin|DRUG: Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Educational and Professional Supportive Interventions on Nursing Home Quality Indicators
Status: COMPLETED
Conditions: Quality Indicators|Physical Disability
Interventions: BEHAVIORAL: Audit and Feedback|BEHAVIORAL: Cooperative Work
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pilot Study to Assess Safety and Feasibility of Resuscitation of Preterm Infants With Controlled Volume of Air/Oxygen
Status: TERMINATED
Conditions: Resuscitation
Interventions: PROCEDURE: Controlled tidal volume resuscitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: ECT
Clinical trial: Study of Brain Anatomo-functional Substrates Related to the Use of Human Tool by Means of Simultaneous Acquisition of Magnetic Resonance Imaging and Electroencephalogram
Status: RECRUITING
Conditions: Patients With Frontal and Parietal Lobe Dysfunction
Interventions: COMBINATION_PRODUCT: electroencephalogram (EEG) and magnetic resonance (MR)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Influence of Local Anesthetic Administration on the Cancer Recurrence Rate After Pancreatic Oncologic Surgery
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Intravenous lidocaine|DRUG: Epidural ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Colchicine and Post-COVID-19 Pulmonary Fibrosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Covid19|Pulmonary Fibrosis Interstitial
Interventions: DRUG: Colchicine 0.5 MG|OTHER: the standard protocol only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cups or Cash for Girls Trial to Reduce Sexual and Reproductive Harm and School Dropout
Status: COMPLETED
Conditions: Reproductive Health|Herpesvirus Infection|HIV Infections|Woman Abuse|Quality of Life|Adolescent Behavior
Interventions: DEVICE: Menstrual Cup|OTHER: Cash transfer|OTHER: Cups and Cash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pentoxifylline as an Adjuvant Therapy in the Treatment of Pediatric Pneumonia; A New Perspective of an Old Drug
Status: NOT_YET_RECRUITING
Conditions: Pentoxifylline as an Adjunct Therapy in the Treatment of Pneumonia
Interventions: DRUG: Pentoxifylline Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of Treatment With Rituximab on the Progression of Humoral Acute Rejection After Renal Transplantation
Status: UNKNOWN
Conditions: Graft Rejection
Interventions: DRUG: MabThera|DRUG: Physiological serum (Sodium Chloride, sodium citrate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phenobarbital for Severe Acute Alcohol Withdrawal Syndrome
Status: TERMINATED
Conditions: Alcohol Withdrawal Delirium|Alcohol Withdrawal|Alcohol Withdrawal Seizures
Interventions: DRUG: Phenobarbital Sodium|DRUG: Inactive placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Computerized Counseling to Promote Positive Prevention and HIV Health in Kenya
Status: COMPLETED
Conditions: HIV Infections
Interventions: OTHER: CARE+ Kenya brief computer risk assessment session|OTHER: CARE+ Kenya computer counseling session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluating Microneedling With CBD and Hempseed Oil for Acne Vulgaris Safety and Efficacy
Status: NOT_YET_RECRUITING
Conditions: Acne Vulgaris (Disorder)
Interventions: COMBINATION_PRODUCT: Microneedling with CBD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Ingestion of Human, Cow, and Modified-cow Milk, on Glucose and Hormone Responses in Humans.
Status: COMPLETED
Conditions: Insulin Tolerance|Hormone|Aminoacidaemia
Interventions: DIETARY_SUPPLEMENT: natural cow|DIETARY_SUPPLEMENT: high protein cow milk|DIETARY_SUPPLEMENT: natural human|DIETARY_SUPPLEMENT: low protein cow milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Improving Diagnosis of Breast Cancer by Using a Combined MRI and Positron Emission Mammography (MRI-PEM) System
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DEVICE: MRI + PEM image
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: High Dose Therapy and Peripheral Blood Stem Cell Transplantation in HIV Related Non Hodgkin Lymphoma (NHL) at High Risk
Status: COMPLETED
Conditions: HIV-related Lymphoma|HIV Infections
Interventions: OTHER: Rituximab and CHOP regimen + PBSCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Multidisciplinary Medication Review With Follow-up for Patients Treated With Coumarin Anticoagulants in Primary Care
Status: COMPLETED
Conditions: Anticoagulant|Pharmacogenetics|Community Pharmacy Services|Drug Utilization Review|Medication Therapy Management
Interventions: OTHER: acenocoumarol|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acetazolamide to Prevent Impending Altitude-illness in Patients With COPD
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease|Altitude Sickness|Altitude Hypoxia
Interventions: DRUG: Acetazolamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: VAC069: A Study of Blood-stage Controlled Human P. Vivax Infection
Status: UNKNOWN
Conditions: Malaria, Vivax
Interventions: BIOLOGICAL: P. vivax infected inoculum (parasitised red blood cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Circadin® 2 mg in the Treatment of Primary Insomnia Patients
Status: COMPLETED
Conditions: Primary Insomnia
Interventions: DRUG: Circadin|DRUG: placebo circadin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Plasma Exchange and Glucocorticoids for Treatment of Anti-Neutrophil Cytoplasm Antibody (ANCA) - Associated Vasculitis
Status: COMPLETED
Conditions: Granulomatosis With Polyangiitis (Wegener's) (GPA)|Microscopic Polyangiitis (MPA)
Interventions: PROCEDURE: Plasma Exchange|OTHER: No Plasma Exchange|DRUG: Glucocorticoids [Standard Dose]|DRUG: Glucocorticoids [Reduced Dose]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid-induced Hyperalgesia After Remifentanil Infusion
Status: COMPLETED
Conditions: Hyperalgesia
Interventions: DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Changes of Visual Function, Ocular Surface Structures and Physiology After Long-Termed Contact Lens Wear
Status: UNKNOWN
Conditions: Ocular Surface Disease|Keratoconus|Irregular Astigmatism
Interventions: DEVICE: corneal lenses|DEVICE: large diameter lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Newborn Cortical Response to Pain and Non Pharmacological Analgesia
Status: COMPLETED
Conditions: Analgesia
Interventions: OTHER: Oral glucose solution + maternal holding|OTHER: Breastfeeding|OTHER: Oral glucose solution|OTHER: Oral expressed breastmilk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy, Safety and Immunological Evaluation of Tofacitinib in the Treatment of Primary Sjogren's Syndrome
Status: UNKNOWN
Conditions: Primary Sjögren's Syndrome
Interventions: DRUG: Tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecule Removal and Ease of Use: A Comparison of Two Different Dialyzers
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DEVICE: Polyflux 210H dialyzer|DEVICE: Polyflux HD-C4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Research Study for Treatment of Children and Adolescents With Acute Myeloid Leukaemia 0-18 Years
Status: UNKNOWN
Conditions: Pediatric Acute Myeloblastic Leukemia
Interventions: DRUG: Randomisation course 1 mitoxantrone versus DaunoXome|DRUG: Randomisation course 2 ADxE versus FLADx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Hydrochloride and Tanespimycin in Treating Patients With Stage IV Pancreatic Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage IV Pancreatic Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: tanespimycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Meningeal Lymphatic Vessels in the Absorption of Chronic Subdural Hematoma and Its Injury Mechanism
Status: UNKNOWN
Conditions: Hematoma, Subdural, Chronic
Interventions: PROCEDURE: subdural hematoma burr hole drainage|DRUG: drug conservative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Acupuncture for Treatment of Acute Spinal Cord Injury: an Exploratory/Developmental Study
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: PROCEDURE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate CBP-201, Rademikibart, in Adult Patients With Chronic Rhinosinusitis With Nasal Polyps
Status: TERMINATED
Conditions: Chronic Rhinosinusitis With Nasal Polyps
Interventions: DRUG: CBP-201|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Benefits of Immunonutrition in Patients With Head and Neck Cancer Receiving Chemoradiation
Status: COMPLETED
Conditions: Oral Mucositis
Interventions: DIETARY_SUPPLEMENT: Oral Impact®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SEALANT-DK: Longevity and Efficacy of 6 Resin Sealants Used for Sealing Permanent Teeth in Children and Adolescents
Status: UNKNOWN
Conditions: Dental Caries
Interventions: OTHER: Fissure sealing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture Therapy for COVID-Related Olfactory Loss
Status: COMPLETED
Conditions: Olfactory Dysfunction|COVID-19
Interventions: DEVICE: Acupuncture Therapy|DRUG: Budesonide|OTHER: Olfactory Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Tafamidis in Patients With Transthyretin Cardiomyopathy
Status: COMPLETED
Conditions: Transthyretin (TTR) Amyloid Cardiomyopathy
Interventions: DRUG: Tafamidis|DRUG: Tafamidis|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mind-Body Walking Exercise for Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Exercise|Anxiety|Depression|Dyspnea|Quality of Life|Heart Rate Variability
Interventions: BEHAVIORAL: Mind-Body Walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diagnostic Value of sFlt-1/PlGF Ratio for the Etiology of Intra Uterine Growth Restriction - ANGIOPAG
Status: UNKNOWN
Conditions: Intrauterine Growth Restriction|Fetal Growth Restriction (FGR)
Interventions: BIOLOGICAL: Blood test at time of inclusion for sFlt-1/PlGF ratio|BIOLOGICAL: Follow-up blood test 2 to 4 weeks after inclusion|DIAGNOSTIC_TEST: Placenta analysis for all included patients, even in case of normal birthweight
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Fluoride Delivery to Prevent White Spots During Orthodontic Treatment
Status: RECRUITING
Conditions: Orthodontic Appliance Complication|Tooth Demineralization
Interventions: DRUG: Fluoride mouthwash (0.05%; 225ppm).|DRUG: Tooth Mousse Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transcutaneous Pulsed Radiofrequency in Migraine
Status: ACTIVE_NOT_RECRUITING
Conditions: Migraine Disorders
Interventions: DRUG: Bupivacaine Hydrochloride|OTHER: Transcutaneous pulsed radiofrequency qurrent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Glucocorticoids on Cognition in HIV-infected Women
Status: COMPLETED
Conditions: Hiv
Interventions: DRUG: Hydrocortisone|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of BGB-21447, a Bcl-2 Inhibitor, in Mature B-Cell Malignancies
Status: RECRUITING
Conditions: Relapsed Non-Hodgkin Lymphoma|Refractory Non-Hodgkin Lymphoma|Relapsed Chronic Lymphocytic Leukemia|Refractory Chronic Lymphocytic Leukemia|Relapsed Follicular Lymphoma|Relapsed Marginal Zone Lymphoma|Relapse Diffuse Large B Cell Lymphoma|Relapsed Small Lymphocytic Lymphoma|Refractory Follicular Lymphoma|Refractory Marginal Zone Lymphoma|Refractory Small Lymphocytic Lymphoma|Richter Transformation|Refractory Diffuse Large B-cell Lymphoma|Transformed Non-Hodgkin Lymphoma
Interventions: DRUG: BGB-21447
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Corneal Measurements Estimate the Corrected Distance Visual Acuity After Corneal Cross-linking
Status: COMPLETED
Conditions: Keratoconus
Interventions: PROCEDURE: corneal cross-linking procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Thrombgolytic and Anticoagulation Therapy in Submassive Pulmonary Embolism
Status: COMPLETED
Conditions: Pulmonary Embolism
Interventions: DRUG: Actilyse (Thrombolytic therapy)|DRUG: Heparine (Standard anticoagulation therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Dose Study of Two Liquidia Bupivacaine Formulations
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: LIQ865A bupivacaine formulation|DRUG: LIQ865B bupivacaine formulation|DRUG: Diluent for LIQ865|DRUG: 0.5% bupivacaine hydrochoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Tailored Psychological Intervention (MITIG.RA) for Managing Fatigue in Rheumatoid Arthritis
Status: NOT_YET_RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: BEHAVIORAL: Intervention Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomised Placebo Controlled Study of Effects of Therapeutic Hookworm Infection in Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: PROCEDURE: Infection with hookworm larvae
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Human Dehydrated Amnion Chorion Allograft in Closed Hemorroidectomy
Status: COMPLETED
Conditions: External Hemorrhoid|External Hemorrhoid Thrombosed
Interventions: OTHER: Human dehydrated amnion chorion allograft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk Factors for AD-Associated Switch to Mania
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Selective Serotonin Reuptake Inhibitors (SSRI), Serotonin-Norepinephrine Reuptake Inhibitor( SNRI), and Tricyclics.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 24 Month Extension to Efficacy and Safety of AEB071 Plus Tacrolimus (Converted to Mycophenolic Acid After 3 Months) in Renal Transplant Patients(Converted to Mycophenolic Acid After 3 Months) in Renal Transplant Patients
Status: TERMINATED
Conditions: Kidney Transplantation
Interventions: DRUG: AEB071|DRUG: mycophenolic plus tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Full Face Mask and Headgear for the Treatment of Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Investigative Full Face Mask with Headgear
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CT-RD06 Cell Injection in Patients With Relapsed or Refractory CD19+ B-cell Hematological Malignancy
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia|Non-Hodgkin's Lymphoma
Interventions: BIOLOGICAL: CT-RD06
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alcohol Disorder hOsPital Treatment Trial
Status: COMPLETED
Conditions: Heavy Drinking|Alcohol Dependence|Alcohol Use Disorder
Interventions: DRUG: Oral naltrexone (PO-NTX)|DRUG: Extended-release injectable naltrexone (XR-NTX)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Electrical Nerve Stimulation (TENS) for Advanced Cancer Pain Patients
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: DEVICE: Modulated TENS|DEVICE: Placebo TENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Evaluation of Teeth Prepared With Vertical Preparation Versus Deep Chamfer
Status: COMPLETED
Conditions: Single Posterior Crowns|Endodontically Treated Teeth|Decayed Teeth
Interventions: OTHER: monolithic zirconia single posterior crowns with deep chamfer finish line|OTHER: monolithic zirconia single posterior crowns with vertical finish line
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Arterial Puncture Using Insulin Syringe is Less Painful Than Standard Syringe
Status: COMPLETED
Conditions: Pain
Interventions: DEVICE: Standard needle BBraun Sterican® 23G and 25mm in length|DEVICE: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Canagliflozin Versus Metformin in Women With Polycystic Ovary Syndrome
Status: NOT_YET_RECRUITING
Conditions: Polycystic Ovary Syndrome|Non-Alcoholic Fatty Liver Disease
Interventions: DRUG: Canagliflozin 100mg Tab|DRUG: Metformin Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Abdominal Aortic Aneurysm Stent Graft System
Status: ACTIVE_NOT_RECRUITING
Conditions: Abdominal Aortic Aneurysm
Interventions: DEVICE: Abdominal Aortic Aneurysm Stent Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erythropoietin in Management of Neonatal Hypoxic Ischemic Encephalopathy
Status: UNKNOWN
Conditions: Hypoxic-Ischemic Encephalopathy
Interventions: DRUG: Erythropoietin|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of bbT369 in Relapsed and/or Refractory B Cell Non-Hodgkin's Lymphoma (NHL)
Status: RECRUITING
Conditions: Diffuse Large B Cell Lymphoma (DLBCL)
Interventions: BIOLOGICAL: bbT369
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Membrane Lipid Replacement in Fibromyalgia
Status: SUSPENDED
Conditions: Fibromyalgia
Interventions: DIETARY_SUPPLEMENT: NTFactor Lipids®|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Immunogenicity of a Candidate Malaria Vaccine Using Novel Routes of Administration
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: ChAd63-METRAP|BIOLOGICAL: MVA ME-TRAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination Treatment With REP 2139-Ca and Pegasys in Patients With Chronic Hepatitis B
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: REP 2139-Ca|DRUG: pegylated interferon|DRUG: entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safinamide as Add-On Therapy in Patients With Early Idiopathic Parkinson's Disease Treated With a Stable Dose of a Single Dopamine Agonist (12 Month Extension)
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Safinamide|DRUG: Safinamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Defurocumarinized Bergamot in the Treatment of Agitation in Severe Dementia Patients.
Status: UNKNOWN
Conditions: Severe Dementia|Stroke
Interventions: DEVICE: defurocumarinized bergamot loaded in a nanotechnological essential oil release system|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 7 Day Study of Mast Cell Inhibitor, R926112, in Patients With Symptomatic Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal
Interventions: DRUG: R926112|DRUG: Beclomethasone dipropionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Acceptability of Nutrient Supplements Among Women and Children in Bangladesh
Status: COMPLETED
Conditions: Malnutrition
Interventions: DIETARY_SUPPLEMENT: Lipid-based nutrient supplement|DIETARY_SUPPLEMENT: Lipid-based nutrient supplement|DIETARY_SUPPLEMENT: Micronutrient powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Single Ascending Dose Study in Healthy Participants and Multiple Dose Study of JNJ-55920839 in Participants With Mild to Moderate Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus|Healthy
Interventions: DRUG: JNJ-55920839|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Protection of Corneal Epithelium Using Chitosan-N-acetylcysteine Eye Drops During and/or After Cataract Surgery
Status: COMPLETED
Conditions: Eye Diseases
Interventions: DEVICE: Lacrimera
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomized Phase III Study to Assess the Effect of a Longer Duration of Consolidation Treatment With Nilotinib on TFR in CP CML.
Status: COMPLETED
Conditions: Philadelphia Chromosome Positive (PH+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP)
Interventions: DRUG: Nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Effects of SIMT and EM in Prolonged Mechanically Ventilated Patients
Status: NOT_YET_RECRUITING
Conditions: Ventilator Dependent
Interventions: OTHER: Inspiratory muscle training (IMT) group|OTHER: Early mobilization (EM) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Demand Creation Strategies for Voluntary Medical Male Circumcision (VMMC) in Kenya
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: OTHER: Inter-personal Communication (IPC)|OTHER: Dedicated Service Outlets (DSO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of an Intervention Program Targeted at Improving Balance and Functional Skills After Stroke
Status: COMPLETED
Conditions: Cerebrovascular Accident|Musculoskeletal Equilibrium
Interventions: BEHAVIORAL: high intensity functional exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Phase 1 Follow-on Study of AAV2-hRPE65v2 Vector in Subjects With Leber Congenital Amaurosis (LCA) 2
Status: ACTIVE_NOT_RECRUITING
Conditions: Leber Congenital Amaurosis
Interventions: BIOLOGICAL: voretigene neparvovec-rzyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alisertib and Fulvestrant in Treating Patients With Hormone Receptor Positive Breast Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Estrogen Receptor Positive|Progesterone Receptor Positive|Recurrent Breast Carcinoma|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: Alisertib|DRUG: Fulvestrant|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of M281 Administered to Pregnant Women at High Risk for Early Onset Severe Hemolytic Disease of the Fetus and Newborn (HDFN)
Status: ACTIVE_NOT_RECRUITING
Conditions: Hemolytic Disease of the Fetus and Newborn
Interventions: DRUG: M281
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: inDuctIon tREatment With subCuTaneous Infliximab for Crohn's Disease
Status: RECRUITING
Conditions: Inflammatory Disease|Disease Crohn|Bowel Disease
Interventions: DRUG: Infliximab subcutaneous|DRUG: Immunosuppressive Agents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Gain Information on the Drug Xarelto for the Prevention of Brain Attack and Blockage of an Artery in the Non-central Nervous System Due to Irregular Heartbeat in Taiwanese Patients Suffering From Decreased Renal Function
Status: COMPLETED
Conditions: Non-valvular Atrial Fibrillation (NVAF)
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase II Study of Gimatecan (ST1481) in Locally Advanced or Metastatic Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: DRUG: Gimatecan|DRUG: tegafur, gimeracil and oteracil potassium|DRUG: gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0340 MRI and Fludeoxyglucose F18 PET in Diagnosing Solitary Plasmacytoma
Status: TERMINATED
Conditions: Multiple Myeloma|Plasmacytoma
Interventions: PROCEDURE: magnetic resonance imaging|PROCEDURE: positron emission tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bevacizumab and Erlotinib Hydrochloride in Treating Patients With Metastatic or Unresectable Biliary Tumors
Status: COMPLETED
Conditions: Cholangiocarcinoma of the Extrahepatic Bile Duct|Cholangiocarcinoma of the Gallbladder|Gastrointestinal Cancer|Recurrent Extrahepatic Bile Duct Cancer|Recurrent Gallbladder Cancer|Unresectable Extrahepatic Bile Duct Cancer|Unresectable Gallbladder Cancer
Interventions: DRUG: erlotinib hydrochloride|BIOLOGICAL: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Treating Relapsed Acute Lymphoblastic Leukemia With Venetoclax and Navitoclax
Status: ACTIVE_NOT_RECRUITING
Conditions: Refractory Acute Lymphoblastic Leukemia|Relapsed Acute Lymphoblastic Leukemia
Interventions: DRUG: Venetoclax|DRUG: Navitoclax|DRUG: Dexamethasone|DRUG: Vincristine|DRUG: Calaspargase Pegol|DRUG: Dasatinib|DRUG: Cytarabine|BIOLOGICAL: Blinatumomab|DRUG: Methotrexate|DRUG: Mercaptopurine|DRUG: Cyclophosphamide|DRUG: Etoposide|DRUG: Leucovorin|DRUG: Intrathecal Triples|DRUG: Pegaspargase|DRUG: Erwinia asparaginase|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Esophageal Cytology With FISH in Detecting Esophageal Cancer
Status: COMPLETED
Conditions: Dysphagia|Dysplasia|Esophageal Adenocarcinoma|Esophageal Squamous Cell Carcinoma|Esophagitis|Gastroesophageal Reflux Disease|High Grade Dysplasia in Barrett Esophagus|Weight Loss
Interventions: OTHER: Cytology Specimen Collection Procedure|PROCEDURE: Esophagogastroduodenoscopy|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Possible Effects of Energy Drink Ingestion on Perceived Alcohol Intoxication
Status: UNKNOWN
Conditions: Perceived Alcohol Intoxication
Interventions: DRUG: Placebo (without alcohol, caffeine, energy drink)|DRUG: Comparator 1 (with alcohol; without caffeine and energy drink)|DRUG: Comparator 2 (with alcohol and caffeine; without energy drink)|DRUG: Comparator 3 (with alcohol and energy drink)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT