pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Efficacy Study of Sotagliflozin on Glucose Control in Participants With Type 2 Diabetes, Moderate Impairment of Kidney Function, and Inadequate Blood Sugar Control
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Chronic Kidney Disease Stage 3
Interventions: DRUG: Placebo|DRUG: Sotagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pasireotide in People With Prolactinoma
Status: RECRUITING
Conditions: Prolactin-Producing Pituitary Tumor
Interventions: DRUG: Pasireotide|OTHER: SF-36 and HADS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Investigating The Effects Of An Ankle Rehabilitation Program On High School Athletes With Ankle Instability
Status: COMPLETED
Conditions: Chronic Ankle Instability|Ankle Sprains|Ankle Rehabilitation
Interventions: OTHER: Resistance Band Ankle Rehabilitation|OTHER: Biomechanical Ankle Platform System Rehabilitation|OTHER: Combination Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Rituximab Versus Mycophenolate Mofetil in Children With Steroid-dependent Idiopathic Nephrotic Syndrome.
Status: RECRUITING
Conditions: Nephrotic Syndrome Steroid-Dependent
Interventions: DRUG: Rituximab Biosimilar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment
Status: RECRUITING
Conditions: Hodgkin Lymphoma in Remission|Leukemia in Remission|Lymphoblastic Lymphoma|Osteosarcoma|Recurrent Leukemia|Recurrent Lymphoma|Recurrent Malignant Neoplasm
Interventions: OTHER: Assessment of Therapy Complications|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Impact of Telephone and Short Message System Based Education on Bowel Preparation for Colonoscopy
Status: COMPLETED
Conditions: Bowel Preparation
Interventions: OTHER: Telephone based re-education|OTHER: Short message system based re-education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Tolerability Study of INCB053914 in Combination With INCB050465 in Diffuse Large B-Cell Lymphoma
Status: COMPLETED
Conditions: Relapsed Diffuse Large B-Cell Lymphoma|Refractory Diffuse Large B-Cell Lymphoma
Interventions: DRUG: INCB053914|DRUG: INCB050465
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-Luer Butterfly Needle With One-way Valve for the Epidural Blood Patch: Does it Alter Blood Clotting?
Status: COMPLETED
Conditions: Post-Dural Puncture Headache|Low Pressure Headache
Interventions: DIAGNOSTIC_TEST: Thromboelastography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Tasisulam-sodium Versus Paclitaxel as Treatment for Metastatic Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: Tasisulam-sodium|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Montelukast to Treat Children With Mild to Moderate Acute Asthma
Status: COMPLETED
Conditions: Asthma, Bronchial
Interventions: DRUG: Montelukast plus prednisolone|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Can Recombinant Human Intrinsic Factor Be Used for Evaluation of the Vitamin B12 Absorption?
Status: COMPLETED
Conditions: Vitamin B12 Deficiency
Interventions: DRUG: Recombinant human intrinsic factor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Trial on the Safety and Efficacy of Magnesium Doped Calcium Silicate 3d Alveolar Bone Repair Unit for Periodontal Bone Defects
Status: RECRUITING
Conditions: Alveolar Bone Loss
Interventions: DEVICE: GBR with CS@Mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Healing of Persistent Epithelial Defects
Status: WITHDRAWN
Conditions: Cornea
Interventions: DRUG: carboxymethylcellulose sodium|DEVICE: Acuvue Oasys Bandage Contact Lens|DEVICE: Ambiodisk|DEVICE: Prokera
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Apatinib Plus IE Chemotherapy (Ifosfamide and Etoposide) for Relapsed or Refractory Osteosarcoma
Status: SUSPENDED
Conditions: Effect of Drug|Toxicity, Drug
Interventions: DRUG: apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Bundle of Non-pharmacological Interventions on the Stress Response to Surgery
Status: NOT_YET_RECRUITING
Conditions: Surgical Injury|Stress, Physiological|Stress, Psychological|Pain, Postoperative
Interventions: OTHER: implementation of a bundle of non-pharmacological interventions aimed at stress reduction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Hypertension in Tibetan Adult Population
Status: UNKNOWN
Conditions: Hypertension
Interventions: DRUG: Nitrendipine|DRUG: Hydrochlorothiazide|DRUG: Captopril,Hydrochlorothiazide|DRUG: Beijing hypotensive No.0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A University-Community Partnership to Reduce Exposure to Disinfection Byproducts In Appalachia
Status: RECRUITING
Conditions: Disinfection By-products
Interventions: OTHER: Citizen Scientist Training Program|OTHER: Stakeholder Consultation Core Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessment of the Psycho-social Impact of COVID-19 Outbreak
Status: COMPLETED
Conditions: SARS-CoV 2|COVID-19|Quality of Life|Mental Health Wellness 1|Social Distance|SARS (Disease)|Psychological
Interventions: BEHAVIORAL: COM-COVID anonimous survey
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Inspiratory Muscle Training for Chronic Kidney Disease Patients on Hemodialysis
Status: COMPLETED
Conditions: Chronic Kidney Disease Stage 5 on Dialysis
Interventions: OTHER: Inspiratory Muscle Training with an intensity of 50% MIP|OTHER: Inspiratory Muscle Training with an intensity of 10% MIP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Solifenacin Succinate for Treatment of Urinary Toxicity Occurring During Radiotherapy of Prostatic Cancer
Status: TERMINATED
Conditions: Overactive Bladder
Interventions: DRUG: Succinate of Solifenacin|DRUG: Placebo of Succinate of Solifenacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Clinical Efficacy of Augmentin® Extra Strength-600 in Children With Acute Otitis Media in India
Status: COMPLETED
Conditions: Otitis Media|Infections, Respiratory Tract|Respiratory Tract Infections
Interventions: DRUG: Augmentin (ES)-600
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fulvestrant +/- Akt Inhibition in Advanced Aromatase Inhibitor Resistant Breast Cancer
Status: UNKNOWN
Conditions: Estrogen Receptor Positive Breast Cancer
Interventions: DRUG: AZD5363|DRUG: Placebo|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Experimental Evaluation of Semillas de Apego
Status: COMPLETED
Conditions: Child Development|Attachment Disorder|Exposure to Violent Event|Parenting
Interventions: BEHAVIORAL: Semillas de Apego
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Hematopoietic Stem Cell Activity in Adipose Tissue From Type 2 Diabetic Patients and Healthy Volunteers
Status: COMPLETED
Conditions: Type2 Diabetes
Interventions: PROCEDURE: Abdominal subcutaneous biopsies and Blood test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)
Status: RECRUITING
Conditions: Relapsing Multiple Sclerosis|Multiple Sclerosis
Interventions: OTHER: No Intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial to Evaluate the Correlation Between Spontaneous Catch-up Growth, Clinical Response to Saizen (Recombinant Human Growth Hormone, r-hGH) and Gene Expression Profiling in Children Small for Gestational Age (SGA)
Status: TERMINATED
Conditions: Infant, Small for Gestational Age
Interventions: DRUG: Recombinant human growth hormone (r-hGH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of the Ophthalmic Solution PRO-179 Compared With Travatan®
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: PRO 179|DRUG: Travatan 0.004 % Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Superficial Cervical Plexus Block and Quality of Recovery After Thyroidectomy
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: DRUG: Bupivacaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cerebellum and Autism: Regional Specialization for Social and Executive Functions
Status: RECRUITING
Conditions: Autism|Autism Spectrum Disorder
Interventions: DEVICE: Transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer
Status: COMPLETED
Conditions: Anal Cancer
Interventions: DRUG: cisplatin|DRUG: fluorouracil|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Curcumin Supplement in Nonalcoholic Fatty Liver Patients
Status: COMPLETED
Conditions: Type 2 Diabetes|Nonalcoholic Fatty Liver
Interventions: DIETARY_SUPPLEMENT: curcumin|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Temporary Clamping of Drains Combined With Tranexamic Acid Reduce Blood Loss After TKA: A Prospective RCT
Status: COMPLETED
Conditions: Osteoarthritis of Knee
Interventions: DRUG: Tranexamic acid|PROCEDURE: Drain clamping|OTHER: Drain clamping and tranexamic acid|OTHER: No clamp and placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating an Online Parenting Support System Disseminated by Pediatric Practices
Status: COMPLETED
Conditions: Child Disruptive Behavior Disorders|Oppositional Defiant Disorder|Conduct Disorder|Attention Deficit Hyperactivity Disorder
Interventions: OTHER: Triple P Online System|BEHAVIORAL: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Double-Blind, Placebo-Controlled Study of Aripiprazole Adjunctive to Antidepressant Therapy
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Aripiprazole 5mg|DRUG: Aripiprazole 2mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Amantadine for Weight Stabilization During Olanzapine Treatment
Status: COMPLETED
Conditions: Psychotic Disorder|Schizophreniform Disorder|Schizophrenia|Schizoaffective Disorder|Mood Disorders With Psychotic Features
Interventions: DRUG: Olanzapine, Amantadine|DRUG: Olanzapine and placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effects of Sitagliptin (MK0431) and Metformin on Incretin Hormone Concentrations (0431-050)(COMPLETED)
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: sitagliptin phosphate|DRUG: Comparator: metformin|DRUG: Comparator: sitagliptin and metformin|DRUG: Comparator: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Liver Fat Content and Visceral Fat Mass in Overweight and Obese Type 2 Diabetes Patients After Treatment With Basal Insulin
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: insulin detemir|DRUG: neutral protamine insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Stereotactic Body Radiation Therapy and Avelumab Immunotherapy for Treatment of Malignant Mesothelioma
Status: COMPLETED
Conditions: Malignant Mesothelioma (MPM)
Interventions: DRUG: Avelumab|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics Trial of JDP-205 Injection 10 mg
Status: COMPLETED
Conditions: Acute Urticaria
Interventions: DRUG: JDP-205 IV high dose|DRUG: JDP-205 IV low dose|DRUG: JDP-205 IM|DRUG: Control: Zyrtec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Tolerability of Different SAR153191 Drug Products, That Differ With Respect to Manufacturing Processes and Formulation, at Different Concentrations and Doses in Healthy Male Subjects
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: SAR153191-P3 drug product|DRUG: SAR153191-P2 drug product|DRUG: SAR153191-C1F3 drug product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Age-related Macular Degeneration (AMD) in the Vitamin D and Omega-3 Trial (VITAL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Age-related Macular Degeneration
Interventions: DRUG: Omega-3 fatty acids (fish oil)|DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Vitamin D3 placebo|DIETARY_SUPPLEMENT: Fish oil placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Use of a Vibrotactile Sensory Prosthesis in Patients With Postural Imbalance and Spatial Disorientation
Status: UNKNOWN
Conditions: Vestibular Diseases|Peripheral Neuropathies|Proprioceptive Disorders|Hemispatial Neglect
Interventions: DEVICE: Vibrotactile feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Optimal Treatment for Coronary Drug Eluting Stent In-stent Restenosis
Status: RECRUITING
Conditions: Coronary Stent Restenosis
Interventions: PROCEDURE: Intravascular management of prior implanted coronary drug eluting stent restenosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Clinical Project of Pegylated Recombinant Human Coagulation Factor VIII-Fc Fusion Protein
Status: RECRUITING
Conditions: Severe Hemophilia A
Interventions: DRUG: FRSW117
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SCLERoderma et Adipose-DErived Stroma Cells
Status: UNKNOWN
Conditions: Systemic Sclerosis
Interventions: DRUG: Stromal Vascular fraction|DRUG: Ringer lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Zoledronate in Preventing Bone Loss in Premenopausal Women Receiving Chemotherapy After Surgery For Early Stage Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Osteoporosis
Interventions: DRUG: zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Applying Num Vapocoolant Spray to Cervix Before Paracervical Block to Decrease Pain During Gynecology Procedures
Status: RECRUITING
Conditions: Pain With Paracervical Block|Pain With Gynecology Procedure|Pain
Interventions: DEVICE: Num Vapocoolant Spray|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: QA102 Phase II Study in Subjects With Dry AMD
Status: ACTIVE_NOT_RECRUITING
Conditions: Dry Age-related Macular Degeneration
Interventions: DRUG: QA102/Placebo|DRUG: QA102|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Clinical Trial in Early Stage Huntington's Disease Patients With SEN0014196
Status: COMPLETED
Conditions: Huntington Disease
Interventions: DRUG: SEN0014196 (Low Dose)|DRUG: SEN0014196 (High Dose)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: S1008: Exercise, Diet, & Counseling in Improving Weight Loss in Overweight Female Breast or Colorectal Cancer Survivors
Status: COMPLETED
Conditions: Anxiety Disorder|Breast Cancer|Cognitive/Functional Effects|Colorectal Cancer|Depression|Fatigue|Pain|Psychosocial Effects of Cancer and Its Treatment|Weight Changes
Interventions: BEHAVIORAL: behavioral dietary intervention|BEHAVIORAL: exercise intervention|OTHER: counseling intervention|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Determine the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of AG-348 in Adult Participants With Non-transfusion-dependent Thalassemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Thalassemia
Interventions: DRUG: AG-348
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Impact of Ex Vivo Ozone Injection on Synovial Fluids in Patients Diagnosed With Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Ozone injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluate Safety and Pharmacokinetics of Minocin (Minocycline) for Injection in Subjects With Renal Insufficiency
Status: TERMINATED
Conditions: Renal Insufficiency, Acute|Renal Insufficiency, Chronic|Healthy Subjects
Interventions: DRUG: Minocin (minocycline) for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IdeNtifying High riSk Patients Post Myocardial Infarction With REduced Left Ventricular Function Using External Loop Recorders (INSPIRE-ELR Study)
Status: COMPLETED
Conditions: Post MI Left Ventricular Dysfunction
Interventions: DEVICE: External Loop Recorder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Gabapentin vs Chlordiazepoxide for Ambulatory Alcohol Withdrawal
Status: COMPLETED
Conditions: Alcohol Withdrawal
Interventions: DRUG: Chlordiazepoxide|DRUG: Gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Do Weight Status and the Level of Dietary Restraint Moderate the Relationship Between Package Unit Size and Food Intake?
Status: COMPLETED
Conditions: Overweight
Interventions: OTHER: Package Unit Size - Single Serving|OTHER: Package Unit Size - Standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Rotation of Hydrophobic Acrylic Lenses - Rayner RA0800C & Alcon Clareon & Hoya Nanex & Hoya Vivinex XY1-EM & RayOne EMV Toric
Status: RECRUITING
Conditions: Age Related Cataracts|Astigmatism
Interventions: DEVICE: Intraocular Lens Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcultural Validation in French of the Systemic Lupus Activity Questionnaire (SLAQ) and the Lupus Quality Of Life (LupusQoL) Questionnaire
Status: COMPLETED
Conditions: Lupus
Interventions: OTHER: SLA Questionnaire|OTHER: Lupus Qol Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ACZ885 for the Treatment of Abdominal Aortic Aneurysm
Status: TERMINATED
Conditions: Abdominal Aortic Aneurysm (AAA)
Interventions: DRUG: ACZ885|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Verify Clinical Utility of Point-of-Care (POC) Thyroid Stimulating Hormone (TSH) Test Kits as Compared to Third Generation TSH Test Kit
Status: COMPLETED
Conditions: Hypothyroidism
Interventions: DEVICE: Quantitative POC TSH Kit|DEVICE: Qualitative POC TSH Kit|DEVICE: Third generation TSH Kit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Efficacy and Safety of HIPEC Combined With PD-1 and SOX Chemotherapy for the Translational Treatment of GC or EGJC With PM
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer, Metastatic
Interventions: DRUG: HIPEC|DRUG: Systemic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COmbiNing Cutting and Drug-Eluting Balloon for Resistant Arteriovenous Fistula sTenOsis (CONCERTO)
Status: COMPLETED
Conditions: Arteriovenous Fistula Stenosis
Interventions: DEVICE: Angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In Vivo Involvement of the Cholinergic and Dopaminergic Systems in the Pathophysiology of Apathy.
Status: UNKNOWN
Conditions: Apathy
Interventions: DRUG: Positron Emission Tomography (PET) with [18F]-FDOPA|DRUG: Positron Emission Tomography (PET) with [18F]-FEOBV|DEVICE: Magnetic Resonnance Imaging (MRI)|OTHER: Neuropsychological evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial
Status: RECRUITING
Conditions: Abortion, Second Trimester|PPROM|Rupture, Spontaneous|Fetal Demise|Fetal Death|Fetal Demise From Miscarriage|Fetal Death Before 22 Weeks With Retention of Dead Fetus|Pregnancy Loss|Pregnancy Complications
Interventions: DRUG: Mifepristone|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Real-world Study of Inclisiran Adherence, Treatment Patterns, Patient Characteristics, and Effectiveness in ASCVD Patients With Hypercholesterolemia, ASCVD-risk Equivalent Patients With Hypercholesterolemia and Familial Hypercholesterolemia
Status: COMPLETED
Conditions: Atherosclerotic Cardiovascular Disease|Hypercholesterolemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Memantine in Preventing Side Effects in Patients Undergoing Whole-Brain Radiation Therapy for Brain Metastases From Solid Tumors
Status: COMPLETED
Conditions: Cognitive/Functional Effects|Metastatic Cancer|Neurotoxicity|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: Memantine|OTHER: Placebo|RADIATION: Whole brain radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study Comparing the Pharmacokinetics (PK) of ABP 501 40 mg/0.4 mL (ABP 501-HCF) and ABP 501 40 mg/0.8 ml (ABP 501-LCF) in Healthy Adult Participants
Status: COMPLETED
Conditions: Adalimumab
Interventions: DRUG: ABP 501-HCF|DRUG: ABP 501-LCF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Flavopiridol, Gemcitabine, and Irinotecan in Treating Patients With Unresectable or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: alvocidib|DRUG: gemcitabine hydrochloride|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resynchronization/Defibrillation for Ambulatory Heart Failure Trial in Patients With Permanent Atrial Fibrillation
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Disease|Congestive Heart Failure|Atrial Fibrillation
Interventions: DEVICE: Optimal Medical therapy plus ICD|DEVICE: Optimal Medical therapy plus CRT/ICD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Ranging Study of AIN457 in Patients With Moderate to Severe Chronic Plaque-type Psoriasis
Status: COMPLETED
Conditions: Chronic Plaque-type Psoriasis
Interventions: DRUG: AIN457|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-Intensity Focused Ultrasound for Cocaine Use Disorder
Status: RECRUITING
Conditions: Cocaine Use Disorder|Cocaine Dependence|Cocaine Abuse|Ultrasound
Interventions: DEVICE: Low-Intensity Focused Ultrasound|DEVICE: Sham LIFU device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: In-Vivo Response of P. Falciparum to Antimalarial Treatment in HIV-Infected and HIV-Uninfected Adults
Status: COMPLETED
Conditions: Malaria|HIV|AIDS
Interventions: DRUG: sulfadoxine-pyrimethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SIGnificance of Routine Hysteroscopy Prior to a First 'in Vitro Fertilization'(IVF) Treatment Cycle
Status: COMPLETED
Conditions: Intrauterine Abnormalities in Infertility
Interventions: PROCEDURE: Office hysteroscopy (in combination with a 'Saline Infusion Sonography'(SIS))
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact Evaluation of a Multi-Sectoral Community-Based Approach to Improving Infant and Young Child Feeding in Amhara, Ethiopia
Status: COMPLETED
Conditions: Exclusive Breastfeeding|Complementary Feeding
Interventions: BEHAVIORAL: A&T community-based interventions|BEHAVIORAL: Mass media
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Cancers
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Metastatic Cancer
Interventions: RADIATION: iodine I 131 monoclonal antibody 81C6
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Tissue Therapy of Transsphincteric Anal Fistula
Status: NOT_YET_RECRUITING
Conditions: Anal Fistula
Interventions: DRUG: ADRC injection|DRUG: ADRC001 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vortioxetine for Post-COVID-19 Condition
Status: COMPLETED
Conditions: Post-COVID-19 Condition|Post-COVID-19 Syndrome|Cognitive Impairment
Interventions: DRUG: Vortioxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Study the Effect of Lycopene in Patients With Gum Disease and type2 Diabetes Mellitus
Status: COMPLETED
Conditions: Positive Regulation of Oxidative Stress Process
Interventions: DRUG: Lycored soft gels Jagsonpal Pharma, Systemic 8mgms/day|DEVICE: Scaling and root planing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Liraglutide (A Weight Loss Drug) in High Risk Obese Participants With Cognitive and Memory Issues
Status: RECRUITING
Conditions: Multiple Sclerosis|Long COVID|Long Covid19|Obese|Obesity|Obesity, Morbid|Acute Leukemia in Remission
Interventions: DRUG: Liraglutide Pen Injector [Saxenda]|OTHER: Medication Diary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Germ Cell Tumors
Status: TERMINATED
Conditions: Childhood Germ Cell Tumor|Extragonadal Germ Cell Tumor|Ovarian Cancer|Testicular Germ Cell Tumor
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: epirubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: paclitaxel|DRUG: thiotepa|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Immediate Implants Inserted Through Open Flap, Open Flap and Bone Grafting and Flapless Techniques
Status: COMPLETED
Conditions: Isolated Premolar Edentulous Site
Interventions: DEVICE: Open flap immediate implant|DEVICE: Open flap immediate implant and bone grafting|DEVICE: Flapless immediate implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bronchodilator's Effects on Exertional Dyspnoea in Pulmonary Arterial Hypertension
Status: WITHDRAWN
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Nebulized ipratropium bromide|DRUG: Nebulized combination ipratropium bromide with salbutamol|DRUG: Nebulized Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Potential Disease-Mediated Drug-Drug Interaction in Adult Participants With Active Eosinophilic Esophagitis Receiving Cendakimab
Status: ACTIVE_NOT_RECRUITING
Conditions: Eosinophilic Esophagitis
Interventions: DRUG: Cendakimab|DRUG: CYP substrates
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VTX958 for the Treatment of Moderately to Severely Active Crohn's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn Disease
Interventions: DRUG: VTX958|DRUG: VTX958|DRUG: VTX958 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stress Management in Depressive Disorder: Resilience Training vs. Yoga: Biological, Epigenetic, and Brain Correlates
Status: NOT_YET_RECRUITING
Conditions: Major Depressive Disorder
Interventions: BEHAVIORAL: RASMUS Resilience Training|OTHER: Body-oriented Yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Consolidation Pembrolizumab Following Chemoradiation in Patients With Inoperable/Unresectable Stage III NSCLC
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Tolerability of Intravenous CRS-100 in Adults With Carcinoma and Liver Metastases
Status: COMPLETED
Conditions: Neoplasm Metastasis|Liver Neoplasms|Carcinoma
Interventions: DRUG: CRS-100
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of the Dried Biological Amnion Graft in Patients With Intrauterine Adhesions
Status: UNKNOWN
Conditions: Intrauterine Adhesions
Interventions: PROCEDURE: dried biological amnion graft|DEVICE: Foley balloon|DRUG: estradiol valerate tablets+dydrogesterone Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: An Open-Label Study to Evaluate the Intraduodenal Delivery of Enzymes From Administration of VIOKASE16 in Exocrine Pancreatic Insufficiency (EPI)
Status: COMPLETED
Conditions: Exocrine Pancreatic Insufficiency
Interventions: DRUG: VIOKASE 16
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Investigation of Treating Chronic Fatigue Syndrome After COVID With Pharmacotherapy (Pregabalin) or Complex Rehabilitation
Status: RECRUITING
Conditions: Chronic Fatigue Syndrome|COVID-19, Long Haul
Interventions: DRUG: Pregabalin|BEHAVIORAL: Independent walking training|DRUG: Placebo|BEHAVIORAL: Gradual movement therapy in the ward|BEHAVIORAL: Telerehabilitation|BEHAVIORAL: Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel Alone or in Combination With Enzalutamide for mCRPC Previously Treated With Abiraterone at mHSPC Stage
Status: RECRUITING
Conditions: Prostate Cancer|Castrate Resistant Prostate Cancer
Interventions: DRUG: Enzalutamide 40 MG|DRUG: Docetaxel injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurologic Stem Cell Treatment Study
Status: RECRUITING
Conditions: Neurologic Disorders|Nervous System Diseases|Neurodegenerative Diseases|Neurological Disorders|Stroke|Traumatic Brain Injury|Cadasil|Chronic Traumatic Encephalopathy|Cerebral Infarction|Cerebral Ischemia|Cerebral Stroke|Cerebral Hemorrhage|Parkinson|Multi-System Degeneration|MSA - Multiple System Atrophy|Progressive Supranuclear Palsy|ALS|Amyotrophic Lateral Sclerosis|Neuropathy|Diabetic Neuropathies|Alzheimer Disease|Dementia|Frontotemporal Dementia|Lewy Body Disease|Cognitive Impairment|Lewy Body Variant of Alzheimer Disease
Interventions: PROCEDURE: Intravenous and Intranasal BMSC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Prophylaxis of Recurrent Pouchitis After Fecal Microbiota Transplant in UC With Ileo-anal Anastomosis
Status: RECRUITING
Conditions: Pouchitis
Interventions: OTHER: fecal microbiota|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Curcumin as a Novel Treatment to Improve Cognitive Dysfunction in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Cognition|Psychosis
Interventions: DRUG: Curcumin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Total Preoperative MR Diagnostic Evaluation Versus Standard Diagnostic Evaluation in Patients With Rectal Cancer
Status: TERMINATED
Conditions: Rectal Cancer|Liver Metastasis
Interventions: PROCEDURE: MR colonography and MR of the liver|PROCEDURE: Standard diagnostic evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Nateglinide on Postprandial Glucose Excursion by Restoring Early Phase Insulin Secretion
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Nateglinide|DRUG: Acarbose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Joins® for Managing Lumbar Facetogenic Pain
Status: NOT_YET_RECRUITING
Conditions: Facet Joint Syndrome
Interventions: DRUG: Joins®(Clematidis Radix,Trichosanthes Root,Prunella Spike Extract)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Randomized Multicenter, Open-label Comparison of Preoperative Combination of Trastuzumab and Pertuzumab With or Without Concurrent Taxane Chemotherapy Given for Twelve Weeks in Patients With Operable HER2+/HR- Breast Cancer Within the ADAPT Protocol
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab|DRUG: Pertuzumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Bioavailability Comparison of Two Different Formulations of MNTX Tablets
Status: COMPLETED
Conditions: Normal Volunteers
Interventions: DRUG: MNTX tablet (Formulation 1)|DRUG: MNTX tablet (Formulation 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effectiveness of the Outpatient Classical Ketogenic Diet and Modified Atkins Diet on Seizures Frequency, Nutritional Status and Some Biochemical Factors in Children and Adolescents With Intractable Epilepsy
Status: COMPLETED
Conditions: Epilepsy Intractable
Interventions: OTHER: Classical ketogenic diet|OTHER: Modified Atkins diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Switching From Protease Inhibitor/Ritonavir to Generic Single Tablet Regimen of Tenofovir Alafenamide/Emtricitibine/Dolutegravir
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: generic single tablet TAF/FTC/DTG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Test How Effective and Safe GLPG1205 is for Participants With Idiopathic Pulmonary Fibrosis (IPF)
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: GLPG1205|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Symbiotic Administration on Intestinal Function of Head and Neck Patients Surgically Treated
Status: COMPLETED
Conditions: Head and Neck Cancer|Synbiotics|Nutrition Therapy
Interventions: DIETARY_SUPPLEMENT: Symbiotic|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Metronidazole and Amoxicillin for the Treatment of Type 2 Diabetic Subjects With Periodontitis
Status: UNKNOWN
Conditions: Periodontitis
Interventions: PROCEDURE: SRP|OTHER: Placebo|DRUG: MTZ+AMX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PET Imaging of Radiolabeled Anti-HIV-1 Envelope Monoclonal Antibody (VRC01)
Status: RECRUITING
Conditions: HIV-1-infection
Interventions: DRUG: [89]Zr-DFO-VRC-HIVMAB060-00-AB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Extension Study of Empagliflozin in Patients With Refractory Diabetes Mellitus With Insulin Resistance ( EMPIRE-02 )
Status: UNKNOWN
Conditions: Insulin Resistance - Type A|Insulin Resistance - Type B|Lipoatrophic Diabetes Mellitus|Insulin Resistance Syndrome
Interventions: DRUG: Empagliflozin Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy/Safety of Combination Budesonide/Indacaterol vs Fluticasone/Salmeterol in Patients With COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Budesonide|DRUG: Fluticasone|DRUG: Indacaterol|DRUG: Salmeterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Prebiotics Support the Treatment of Mild Iron Deficiency by Iron Supplementation
Status: UNKNOWN
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Prebiotic (Synergy-1) + Iron supplement|DIETARY_SUPPLEMENT: Placebo (Maltodextrin) + Iron Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Memory and Attention in Healthy Children
Status: UNKNOWN
Conditions: Healthy Volunteers
Interventions: OTHER: Experience 1 : Auditory and Visual Discrimination|OTHER: Experience 2 : Passive and Active Auditory Perception|OTHER: Experience 3 : Visual Attention Training|OTHER: Experience 4 : Attention and Distractibility|OTHER: Experience 5 : Sustained Visual Attention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Feasibility Study for Abused Chinese Immigrant Women
Status: COMPLETED
Conditions: Intimate Partner Violence|Depression|Anxiety|PTSD
Interventions: BEHAVIORAL: Self-Compassion, Health, and Empowerment (SHE)|BEHAVIORAL: The Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Immune Checkpoint Blockade in Resectable Malignant Pleural Mesothelioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Mesothelioma
Interventions: DRUG: Nivolumab Injection|DRUG: Ipilimumab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Incorporation of Dietary Protein-Derived Amino Acids in Duodenal Epithelium
Status: COMPLETED
Conditions: Protein Malabsorption
Interventions: DIETARY_SUPPLEMENT: Intrinsically labelled milk protein
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of Weight Loss Methods on Lifespan for Metabolic Syndrome
Status: RECRUITING
Conditions: Metabolic Syndrome
Interventions: DRUG: Semaglutide, Empagliflozin|PROCEDURE: Minigastric bypass|DIETARY_SUPPLEMENT: Analimentary detoxication|BEHAVIORAL: Ramadan fast's weight loss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation of RMC-5552 Monotherapy in Relapsed/Refractory Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumors
Interventions: DRUG: RMC-5552
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT