pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Pembrolizumab (MK-3475) in Participants With Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma or Relapsed or Refractory Richter Syndrome (MK-3475-170/KEYNOTE-170)
Status: COMPLETED
Conditions: Mediastinal Large B-cell Lymphoma|Richter Syndrome
Interventions: BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock
Status: COMPLETED
Conditions: Septic Shock|Sepsis
Interventions: DRUG: Norepinephrine|DRUG: Ringer's Lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Efficacy and Tolerability of ESO-101 in Patients With Eosinophilic Esophagitis
Status: COMPLETED
Conditions: Eosinophilic Esophagitis
Interventions: DRUG: ESO-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment With Bempedoic Acid And/Or Its Fixed-dose Combination With Ezetimibe in Routine Clinical Practice in Patients With Primary Hypercholesterolemia Or Mixed Dyslipidemia
Status: WITHDRAWN
Conditions: Primary Hypercholesterolemia|Mixed Dyslipidemia
Interventions: DRUG: Bempedoic acid and/or its fixed dose combination with ezetimibe
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Tranexamic Acid in Ruptured Abdominal Aortic Aneurysms
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysms
Interventions: DRUG: Tranexamic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Trial of NK DLI From 6/6 HLA Matched Family Member Following Nonmyeloablative ASCT
Status: COMPLETED
Conditions: Lymphoma
Interventions: DEVICE: NK Cell infusion using CD56 monoclonal antibody|PROCEDURE: Donor Apheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Etomidate, Propofol and Etomidate-propofol Combination in Terms of Effects on Haemodynamic Response to Intubation
Status: COMPLETED
Conditions: Induction of Anaesthesia
Interventions: DRUG: propofol|DRUG: etomidate|DRUG: etomidate-propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial of TQB2102 for Injection in Non-small Cell Lung Cancer With HER2 Gene Abnormality
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: TQB2102 for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testosterone Replacement in Middle-Aged Hypogonadal Men With Dysthymia: Parallel Group, Double Blind Randomized Trial
Status: UNKNOWN
Conditions: Dysthymic Disorder
Interventions: DRUG: Testoviron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Low-volume Polyethylene Glycol Bowel Preparation for Colonoscopy
Status: COMPLETED
Conditions: Bowel Preparation for Colonoscopy
Interventions: DRUG: PEG-3350 group 2|DRUG: PEG-3350 group 1|DRUG: PEG-3350 group 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Lumbar Stabilization Exercises Combined With Ball and Balloon Exercise in Treatment of Chronic Non-specific Low Back Pain
Status: COMPLETED
Conditions: Chronic Mechanical Low Back Pain
Interventions: OTHER: therapeutic exercises|OTHER: exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effectiveness and Safety of Different Doses of ASP1707 Compared to Placebo for Endometriosis Associated Pelvic Pain
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: ASP1707|DRUG: Placebo|DRUG: Leuprorelin acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy, Safety and Tolerability of Photodynamic Therapy(PDT) With Chlorin-e6 in Treating Moderate to Severe Acne
Status: RECRUITING
Conditions: Acne|Photodynamic Therapy
Interventions: DRUG: N-chlorin e6 triglumine|PROCEDURE: acne removal surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ZIMURA in Combination With LUCENTIS in Patients With Neovascular Age Related Macular Degeneration (NVAMD)
Status: COMPLETED
Conditions: Wet Age-related Macular Degeneration
Interventions: DRUG: Zimura|DRUG: Lucentis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-arm Study of Selumetinib in Combination With Docetaxel, in Advanced Gastric Adenocarcinoma Patients With Low/High MEK Signature, RAS Mutation or RAS Amplification as a Second-line Chemotherapy
Status: COMPLETED
Conditions: Gastric Adenocarcinoma
Interventions: DRUG: docetaxel plus selumetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multivessel Balloon Occlusion to Investigate Obstructive Coronary Artery Disease and aNgina
Status: RECRUITING
Conditions: Stable Angina|Multivessel Coronary Artery Disease
Interventions: PROCEDURE: Percutaneous coronary intervention (PCI)|DIAGNOSTIC_TEST: Symptom assessment during experimentally induced ischaemia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Corneal Endothelial Changes After Uneventful Phacoemulsification in Diabetic and Non-diabetic Patients in Relation to the Level of Glcosylated Hemoglobin Level
Status: UNKNOWN
Conditions: Corneal Endothelial Changes After Phacoemulsification
Interventions: DEVICE: Specular biomicroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: pRophylactic halopEriDol Use for Delirium in iCu patiEnts With a High Risk for Delirium
Status: COMPLETED
Conditions: Delirium
Interventions: DRUG: Haloperidol 1 mg/q8h|DRUG: Haloperidol 2 mg/q8h|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Early Prevention of Preeclampsia Study
Status: TERMINATED
Conditions: Preeclampsia
Interventions: DRUG: Aspirin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of SHR-1210 in Combination With Chemotherapy in Advanced Esophageal Cancer
Status: COMPLETED
Conditions: Advanced Esophageal Cancer
Interventions: DRUG: SHR-1210|DRUG: Placebo|DRUG: paclitaxel|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: New Chemotherapy Regimen in the Treatment of Advanced Gallbladder Carcinoma
Status: COMPLETED
Conditions: Gallbladder Neoplasms
Interventions: DRUG: Somatostatin|DRUG: epirubicin, cisplatin, LV（Leucovorin）、 5-FU（5-Fluorouracil）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Avelumab-M3814 Combinations
Status: COMPLETED
Conditions: Oncology|Solid Tumors
Interventions: DRUG: M3814|DRUG: M3814|DRUG: Avelumab|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The TARGET-EFT Randomized Clinical Trial
Status: COMPLETED
Conditions: Frailty|Cardiovascular Diseases in Old Age|Geriatric Cardiology|Quality of Life
Interventions: OTHER: Physical Component of the Intervention|OTHER: Cognitive Component of the Intervention|OTHER: Nutritional Component of the Intervention|OTHER: Iron-Deficiency Anemia (IDA) Component of the Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Bilateral Decompression With Interbody Fusion for Spondylolisthesis
Status: UNKNOWN
Conditions: Lumbar Spondylolisthesis
Interventions: PROCEDURE: Bilateral decompression with TLIF|PROCEDURE: laminectomy with PLIF|DEVICE: Pedicle screw and interbody cage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nasal Lavage Study: Comparing Single Versus Multi Sample Lavages
Status: COMPLETED
Conditions: Nasal Lavage Fluid|Eosinophils|Reproducibility of Results
Interventions: PROCEDURE: Nasal lavage|PROCEDURE: Allergy skin testing|PROCEDURE: Peak nasal inspiratory flow|PROCEDURE: Acoustic rhinometry|PROCEDURE: Nasal examination|PROCEDURE: Quality of Life Questionnaire|PROCEDURE: Physical examination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: PROWESS (PROstate Cancer Wearables Exercise and Structured Supports): A Pilot Supportive Care Intervention
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer|Prostatic Neoplasms
Interventions: BEHAVIORAL: PROWESS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Alcohol Challenge On Liver and Gut Measured by Liver Vein Catheterization. A Pathophysiological Intervention Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Liver Fibroses|Alcohol-Induced Disorders
Interventions: OTHER: Ethanol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess the Efficacy & Safety of KHK4951 in Patients With Neovascular Age-Related Macular Degeneration
Status: RECRUITING
Conditions: Neovascular Age-Related Macular Degeneration (nAMD)
Interventions: DRUG: KHK4951|DRUG: Aflibercept Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Coloring Prompt on Health Engagement
Status: COMPLETED
Conditions: In Need of a Pap Smear (Cervical Cancer Screening)|In Need of a Blood Pressure Check (Hypertension Screening)|In Need of a Cholesterol Test (Lipid Disorder Screening)|In Need of a Fasting Plasma Glucose Test (Diabetes)
Interventions: BEHAVIORAL: Planning Prompt|BEHAVIORAL: Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Testing the Efficacy of an Online Alcohol Intervention
Status: COMPLETED
Conditions: Hazardous Drinking|Harmful Drinking
Interventions: BEHAVIORAL: Online screening and feedback|BEHAVIORAL: Online booklet.|BEHAVIORAL: Online multi session follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effects of Ankle Foot Orthoses on Gait Efficiency in Children With Acute Lymphoblastic Leukemia and Foot Drop
Status: TERMINATED
Conditions: Foot Drop|Acute Lymphoblastic Leukemia
Interventions: DEVICE: AFO Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ultrasound-guided Femoral Nerve Block Without Electrical Stimulation of Peripheral Nerves
Status: COMPLETED
Conditions: Nerve Block|Efficiency|Femoral Nerve|Ultrasonography
Interventions: PROCEDURE: Femoral nerve blockade under ultrasound control with a peripheral nerve stimulator|PROCEDURE: femoral nerve blockade under ultrasound control without a peripheral nerve stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Routine Angioplasty and Stenting After Fibrinolysis for Acute Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: PROCEDURE: Routine Early Percutaneous Coronary Intervention after Thrombolysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Photobiomodulation to Treat Dry Age-Related Macular Degeneration (LIGHTSITE III)
Status: UNKNOWN
Conditions: Dry Age-related Macular Degeneration
Interventions: DEVICE: Valeda PBM treatment|DEVICE: Valeda Sham treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase Ⅱ Study of Anlotinib Combined With Tislelizumab and AT in the Neoadjuvant Treatment of Triple-negative Breast Cancer
Status: RECRUITING
Conditions: Triple-negative Breast Cancer
Interventions: DRUG: AT regimen|DRUG: Tislelizumab|DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Natural Health Product in Children With Attention Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DIETARY_SUPPLEMENT: Zinc, Magnesium, Vitamin B6, Vitamin C (Compound Natural Health Product for ADHD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MOdified Urinary Conduit to Lower Strictures After radIcal Cystectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Bladder Cancer
Interventions: PROCEDURE: Cystectomy and modified urinary conduit|PROCEDURE: Cystectomy and standard urinary conduit ad modum Bricker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mapping for Acute Transvenous Phrenic Nerve Stimulation Study
Status: COMPLETED
Conditions: Sleep Apnea
Interventions: DEVICE: Stimulating the phrenic nerve intravenously using high frequency electrical pulses using an EP catheter connected to external pulse stimulator.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Adding Metformin to the Treatment of Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Metformin|DRUG: pegylated interferon|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NUV-868 as Monotherapy and in Combination With Olaparib or Enzalutamide in Adult Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Ovarian Cancer|Ovary Cancer|Cancer of Ovary|Cancer of the Ovary|Ovary Neoplasm|Pancreatic Cancer|Pancreas Cancer|Cancer of Pancreas|Cancer of the Pancreas|Pancreas Neoplasm|Prostate Cancer|Prostatic Cancer|Cancer of Prostate|Cancer of the Prostate|Prostate Neoplasm|Castrate Resistant Prostate Cancer|Castration Resistant Prostatic Cancer|Castration Resistant Prostatic Neoplasms|Triple-negative Breast Cancer|Triple Negative Breast Cancer|Triple Negative Breast Neoplasms|Breast Cancer|Breast Carcinoma|Cancer of Breast|Cancer of the Breast|Breast Tumor
Interventions: DRUG: NUV-868|DRUG: Olaparib|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacodynamic Study to Evaluate Neutrophil Distribution Kinetics and Function Following Single-Dose RoActemra/Actemra (Tocilizumab) in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: placebo|DRUG: tocilizumab [RoActemra/Actemra]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Phase 3 Trial to Evaluate the Efficacy and Safety of LC15-0444 in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Placebo group(once daily)|DRUG: LC15-0444 50mg qd
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy and Safety of Cresnon® and Crestor® in Patients With Hyperlipidemia
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DRUG: Rosuvastatin(Cresnon®)|DRUG: Rosuvastatin(Crestor®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Distal Radius Fractures in Elderly Patients
Status: WITHDRAWN
Conditions: Distal Radius Fractures
Interventions: PROCEDURE: Distal Radius Fracture Reduction|OTHER: Conservative Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of the Absorption of Vitamin E Water-soluble Form (Pegylated) in the Familial Hypocholesterolemia With Chylomicron Retention
Status: COMPLETED
Conditions: Hypobetalipoproteinemias
Interventions: DRUG: Tocofersolan|DRUG: tocopherol alpha|DRUG: Tocofersolan and tocopherol alpha
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quetiapine to Reduce Post Concussive Syndrome After Mild Traumatic Brain Injury (mTBI)
Status: RECRUITING
Conditions: Mild Traumatic Brain Injury
Interventions: DRUG: Quetiapine Fumarate|DRUG: TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: USG Brachial Plexus Block for Upper Extremity Surgery
Status: COMPLETED
Conditions: Fracture at Wrist and/or Hand Level|Rupture of Tendon of Wrist and Hand|Injuries to the Wrist, Hand and Fingers (S60-S69)|Ganglion Cysts|Carpal Tunnel Syndrome
Interventions: DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characterization of Fatty Acid Composition of Triglycerides in Patients With Hypertriglyceridemia-induced Acute Pancreatitis
Status: UNKNOWN
Conditions: Hypertriglyceridemia
Interventions: OTHER: blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Trial of Adjuvant Chemotherapy in Nasopharyngeal Carcinoma Patients With Residual Epstein-Barr Virus (EBV) DNA Following Radiotherapy
Status: COMPLETED
Conditions: Nasopharyngeal Cancer
Interventions: DRUG: Adjuvant chemotherapy (gemcitabine and cisplatin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Talazoparib - Carboplatin for Recurrent High-grade Glioma With DDRd
Status: UNKNOWN
Conditions: Recurrent Glioma|Recurrent Glioblastoma|Poly ADP Ribose Polymerase (PARP) Inhibitor|PTEN Gene Inactivation|IDH Mutation
Interventions: DRUG: Talazoparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Gamma PN3 in the Elderly
Status: NOT_YET_RECRUITING
Conditions: Pneumonia, Pneumococcal
Interventions: BIOLOGICAL: Gamma PN3|BIOLOGICAL: Prevnar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluate the Effect of Entrectinib on the Pharmacokinetics of Midazolam in Cancer Patients
Status: COMPLETED
Conditions: Advanced Solid Tumor
Interventions: DRUG: Entrectinib|DRUG: Midazolam Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Montelukast With Status Asthmaticus, Ages 2-5
Status: UNKNOWN
Conditions: Status Asthmaticus|Asthma
Interventions: DRUG: Montelukast|OTHER: Sterile water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of SIR-Spheres Plus Sorafenib as 1st Line Treatment for Non-resectable Primary Hepatocellular Carcinoma (HCC)
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Sorafenib|RADIATION: SIR-Spheres
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4
Status: RECRUITING
Conditions: Hereditary Spastic Paraplegia|Hereditary, Spastic Paraplegia, Autosomal Dominant
Interventions: OTHER: SPRS Score and clinical signs|BEHAVIORAL: Cognition Testing using CANTAB|DIAGNOSTIC_TEST: Lumbar Puncture and blood draw|DIAGNOSTIC_TEST: MRI|DIAGNOSTIC_TEST: Electrophysiology|DIAGNOSTIC_TEST: Testing functional performance|DIAGNOSTIC_TEST: Non motor symptoms
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: McLean and Genomind Prospective Study
Status: COMPLETED
Conditions: Major Depressive Disorder|PTSD
Interventions: GENETIC: Phlebotomy - Folate|GENETIC: Cheek Swab|OTHER: Self-report surveys
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pioglitazone vs. Placebo in Association With Pegylated Interferon and Ribavirin in HCV Patients With Insulin Resistance
Status: TERMINATED
Conditions: Chronic Hepatitis C|Insulin Resistance
Interventions: DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sealing Manifest Occlusal Caries Lesions in the Permanent Dentition
Status: COMPLETED
Conditions: Dental Caries
Interventions: PROCEDURE: Non-invasive resin based fissure sealing|PROCEDURE: Invasive resin based restoration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the HIV Protease Inhibitors Atazanavir and Lopinavir/Ritonavir on Cardiovascular Disease Risk Factors
Status: COMPLETED
Conditions: Endothelial Dysfunction
Interventions: DRUG: Atazanavir|DRUG: Lopinavir/ritonavir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: High Dose Versus Routine Dose Icotinib in Advanced Non-small Cell Lung Cancer Patients With Stable Disease
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Routine dose icotinib|DRUG: Higher dose icotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Insulin Detemir on Blood Glucose Control in Taiwanese Patients With Type 2 Diabetes Failing on OAD
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin detemir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Brain Stimulation During Nocturnal Sleep on Memory Consolidation in Elderly Healthy Subjects
Status: COMPLETED
Conditions: Elderly Subjects
Interventions: DEVICE: Stimulation|DEVICE: SHAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fuzhenghuayu in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis
Status: UNKNOWN
Conditions: Primary Biliary Cirrhosis
Interventions: DRUG: Fuzhenghuayu|DRUG: UDCA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Of Double Umbilical Cord Blood Transplantation
Status: COMPLETED
Conditions: Hematological Malignancies
Interventions: PROCEDURE: Full intensity, double umbilical cord, stem cell transplant|DRUG: Flu/Bu4 conditioning regimen|RADIATION: Total Lymphoid Irradiation (TLI)|DRUG: Graft versus Host Disease prevention (GVHD prophylaxis)|DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Use of a Contraceptive Vaginal Ring (NuvaRing) in Normal Daily Practice in Indian Women (P07733)
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Ethinylestradiol + Etonogestrel Vaginal Ring (NuvaRing)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Drug Interaction of SMC021 With Concomitant Antacid (Calcium Carbonate/Magnesium Hydroxide).
Status: COMPLETED
Conditions: Health Postmenopausal Women
Interventions: DRUG: SMC021
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Colorectal Pulmonary Metastases: Pulmonary Metastasectomy Versus Stereotactic Ablative Radiotherapy
Status: NOT_YET_RECRUITING
Conditions: Lung Metastases|Colorectal Cancer Metastatic
Interventions: PROCEDURE: Minimally invasive pulmonary metastasectomy|RADIATION: Stereotactic ablative radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Probiotics on Systemic Inflammation and Metabolic Endotoxemia in Patients Undergoing Bariatric Surgery
Status: UNKNOWN
Conditions: Bariatric Surgery Candidate|Dysbiosis
Interventions: DIETARY_SUPPLEMENT: probiotic supplementation|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioequipotency Study of Idrabiotaparinux and Idraparinux in Patients With Deep Venous Thrombosis of the Lower Limbs
Status: COMPLETED
Conditions: Deep Venous Thrombosis
Interventions: DRUG: Idrabiotaparinux sodium|DRUG: Idraparinux sodium|DRUG: Avidin|DRUG: Placebo (for Avidin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: STOP-CA (Statins TO Prevent the Cardiotoxicity From Anthracyclines)
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Placebo|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: In Vivo Evaluation of Growth and Risk of Rupture of Dilated Ascending Aorta Using 4D Cardiac Magnetic Resonance
Status: COMPLETED
Conditions: Aortic Rupture
Interventions: DEVICE: 4D Cardiac Magnetic Resonance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Essential Oils With and Without Alcohol: Substantivity and Antiplaque Effect
Status: UNKNOWN
Conditions: Oral Biofilm|Dental Plaque|Periodontitis
Interventions: DRUG: Essential oils|DRUG: Alcohol free essential oils|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cabergoline and Hydroxyethyl Starch in Ovarian Hyperstimulation Syndrome Prevention
Status: COMPLETED
Conditions: Complications Associated With Artificial Fertilization|Disorder of Endocrine Ovary
Interventions: DRUG: Cabergoline and Hydroxyethyl Starch|DRUG: Hydroxyethyl Starch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Renal Function Evaluation After Reduction of Cyclosporine A Dose in Renal Transplant Patients
Status: COMPLETED
Conditions: Kidney Transplantation|Primary Prevention|Kidney Failure
Interventions: DRUG: cyclosporine A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventive Regimens With Herbal and Fluoride Toothpaste on Remineralization in High Caries Patients With Initial Lesions
Status: UNKNOWN
Conditions: Dental Caries
Interventions: OTHER: Himalaya complete care toothpaste|OTHER: colgate cavity protection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Chemoradiation for Resectable Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma|Surgery|High Grade Glioma
Interventions: RADIATION: Neoadjuvant chemoradiation|DRUG: Drug Therapy with Temozolomide (benzolamide) (Standard of Care)|PROCEDURE: Surgery post Radiation and Temozolomide (benzolamide)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Video Information on Anxiety in Adolescents Having rRT-PCR Test During Corona Virus Pandemic
Status: COMPLETED
Conditions: Coronavirus
Interventions: OTHER: Adolescents watching an informational video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy of Aliskiren + Hydrochlorothiazide (± Amlodipine 5 mg) in Patients With Moderate Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Candesartan+HCTZ - Phase 1|DRUG: Aliskiren+HCTZ - Phase 2|DRUG: Aliskiren+HCTZ+amlodipine - Phase 3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tegaderm vs. Transpore for Eye Protection During Anesthesia
Status: COMPLETED
Conditions: Eyelid Erythema
Interventions: DEVICE: Tegaderm Eye Tape|DEVICE: Transpore Eye Tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Alpha Lipoic Acid Supplementation and Metabolic Syndrome
Status: UNKNOWN
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Alpha lipoic acid|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety And Efficacy Study Of The Combination Of Oral PF-00299804 And Intravenous CP-751,871 Given Every 3 Weeks
Status: COMPLETED
Conditions: Carcinoma, Non-Small Cell|Neoplasm Metastasis
Interventions: DRUG: PF-00299804
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irinotecan, Capecitabine and Avastin for Metastatic Colorectal Cancer as Salvage Treatment
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Capecitabine|DRUG: Bevacizumab|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet-delivered CBT for Adolescents With Obsessive-Compulsive Disorder - a Pilot Study
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: BEHAVIORAL: Internet-delivered Cognitive Behavior Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Preoperative Pulsed Electromagnetic Field and Abdominal Exercises on Muscle Strength Post Ventral Hernioplasty
Status: COMPLETED
Conditions: Hernia, Ventral
Interventions: OTHER: Pulsed electromagnetic field|OTHER: Graduated abdominal strengthening exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety of Escalating Doses of AT9283, in Patients With Leukemias
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Chronic Myeloid Leukemia|Myelodysplastic Syndromes|Myelofibrosis
Interventions: DRUG: AT9283
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in Women With Idiopathic Menorrhagia to Determine the Reduction in Menstrual Blood Loss (MBL) After Treatment With the Levonorgestrel-releasing Intrauterine System (IUS)
Status: COMPLETED
Conditions: Menorrhagia
Interventions: DRUG: Levonorgestrel IUS (Mirena, BAY86-5028)|DRUG: Medroxyprogesterone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study on Endoscopic Ultrasound (EUS) Celiac Bloc Efficacy in Chronic Pancreatitis
Status: TERMINATED
Conditions: Pancreatitis, Chronic
Interventions: DRUG: EUS procedure with drug injection|OTHER: EUS procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comprehensive Cognitive and Affective Intervention for Mild Cognitive Impairment (MCI) For Foreign-Born Arab Americans
Status: RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: CRT|BEHAVIORAL: CBT|BEHAVIORAL: Modifiable lifestyle factors|BEHAVIORAL: Usual care Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Screening for Adrenal Insufficiency During Dermocorticoid Reduction in Bullous Pemphigoid (BP)
Status: RECRUITING
Conditions: Pemphigoid, Bullous|Adrenal Insufficiency
Interventions: DIAGNOSTIC_TEST: clobetasol decreasing measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Efficacy and Safety of Brodalumab Compared With Placebo in Adults With Inadequately Controlled Asthma With High Bronchodilator Reversibility
Status: TERMINATED
Conditions: Asthma
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: Brodalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Different Stylet Angles for Orotracheal Intubation Using Glidescope® Video Laryngoscope in Children
Status: COMPLETED
Conditions: Intubation
Interventions: DEVICE: Glidescope® with tip manipulated stylet|DEVICE: Glidescope® with standard-curved tip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Study of Biomorkers and Rehabilitation Strategies in Functional Motor Disorders (FMD)
Status: RECRUITING
Conditions: Functional Motor Disorders
Interventions: OTHER: Multidisciplinary Rehabilitation Training|BEHAVIORAL: Cross-sectional study on patients with FMD and patients with structural/organic diseases|BEHAVIORAL: Cross-sectional study on patients with FMD and healthy controls (HC)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Degree of Polymerization and Linkage of α-glucans on Post-prandial Glucose Response
Status: COMPLETED
Conditions: Postprandial Glucose Response
Interventions: DIETARY_SUPPLEMENT: Roquette Glucidex 2|DIETARY_SUPPLEMENT: Pharmacosmos Dextran 10|DIETARY_SUPPLEMENT: Roquette Glucidex 40|DIETARY_SUPPLEMENT: Promitor 70
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Open-Angle Glaucoma Subjects With One Prior Trabeculectomy Treated Concurrently With One Suprachoroidal Stent and Two Trabecular Micro-bypass Stents
Status: COMPLETED
Conditions: Open-Angle Glaucoma
Interventions: DEVICE: iStent and iStent supra
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Targeted Selective Speech, Language, and Communication Intervention at Scale - Protocol for the 'Happy Talk' Cluster Randomised Controlled Trial.
Status: NOT_YET_RECRUITING
Conditions: Developmental Language Disorder and Language Impairment|Deprivation
Interventions: BEHAVIORAL: Happy Talk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cardiac Remodeling and Circulating Biomarkers in Pediatric Left Ventricular Pressure Loading Lesions
Status: COMPLETED
Conditions: Coarctation of Aorta|Aortic Stenosis|Cardiac Hypertrophy
Interventions: PROCEDURE: Echocardiogram|BIOLOGICAL: Serology
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Bed Rest Avoidance Study
Status: COMPLETED
Conditions: Study Focuses on Bed Rest and Deconditioning in Hospital Inpatients
Interventions: BEHAVIORAL: Provision of recliner chairs and encouragement to get out of bed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Enfortumab Vedotin in Japanese Subjects With Locally Advanced or Metastatic Urothelial Carcinoma
Status: COMPLETED
Conditions: Metastatic Urothelial Cancer
Interventions: DRUG: Enfortumab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enriched QUARTET® Hen Eggs and Cardiovascular Function
Status: UNKNOWN
Conditions: n-3 Polyunsaturated Fatty Acids|Selenium|Vitamin E|Lutein
Interventions: DIETARY_SUPPLEMENT: QUARTET® hen eggs (enriched in n-3 PUFA, selenium, vitamin E and lutein)|DIETARY_SUPPLEMENT: Regular hen eggs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Validation of the Triptorelin Test for the Diagnosis of CPP in Girls
Status: COMPLETED
Conditions: Central Precocious Puberty|Sexual Precocity
Interventions: DIAGNOSTIC_TEST: Triptorelin acetate and Gonadorelin acetate|DIAGNOSTIC_TEST: Gonadorelin acetate and Triptorelin acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Immunogenicity and Safety of Human Papillomavirus (HPV)-16/18 Vaccine in Healthy Females
Status: COMPLETED
Conditions: Human Papillomavirus
Interventions: BIOLOGICAL: HPV vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Hydroxyethyl Starch and Crystalloid Coload Combined With Norepinephrine Infusion for Hypotension
Status: COMPLETED
Conditions: Adverse Effect
Interventions: DRUG: Hydroxyethyl starch|DRUG: Crystalloid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicentered Prospective Cohort Study of Chinese IBD Patients
Status: UNKNOWN
Conditions: Ulcerative Colitis|Crohn Disease
Interventions: DRUG: Infliximab|DRUG: Vedolizumab|DRUG: Ustekinumab|DRUG: conventional treatment (glucocoticoid, immunosupressive drugs and/or mesalazine)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Interactive Parent-Targeted Text Messaging in Pediatric Clinics to Reduce Caries Among Urban Children
Status: COMPLETED
Conditions: Caries, Dental|Health Behavior
Interventions: OTHER: OHT Parent targeted text messages|OTHER: CWT Parent targeted text messages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MOVE OUT: A Partnership With Veterans Groups to Enhance Weight Management in the Veterans Health Administration (VHA)
Status: COMPLETED
Conditions: Obesity|Overweight|Hypertension|Diabetes Mellitus
Interventions: BEHAVIORAL: MOVE OUT|BEHAVIORAL: MOVE!
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Memantine for the Prevention of Cognitive Dysfunction and Negative Symptoms in Patients With Acute Schizophrenia
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: Memantine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: PREOPANC-4 Implementation Program for Locally Advanced Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer|Locally Advanced Pancreatic Adenocarcinoma|Pancreatic Adenocarcinoma Non-resectable|Chemotherapy Effect
Interventions: OTHER: Implementation - International best-practice care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase II Trial of Neoadjuvant and Adjuvant Anti-PD-1 Antibody Toripalimab Combined With CCRT in NPC Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Cisplatin+Toripalimab|DRUG: Cisplatin+placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Anti-IL5 Biological Treatments on Blood IgE Levels in Severe Asthmatic Patients
Status: COMPLETED
Conditions: Asthma|Asthma; Eosinophilic
Interventions: DIAGNOSTIC_TEST: Total IgE|DIAGNOSTIC_TEST: Blood cell counts|DIAGNOSTIC_TEST: Asthma control assessment|DIAGNOSTIC_TEST: lung function tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigating the Syndrome Differentiation of Diabetic and Pre-diabetic Using Digitalized TCM Diagnostic Tools
Status: RECRUITING
Conditions: Diabete Mellitus|Pre-diabetes|Healthy|Hypertension|Dyslipidemia Associated With Type II Diabetes Mellitus
Interventions: OTHER: Questionnaires+Tongue diagnosis+Pulse diagnosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Aspirin Use for Gastric Cancer Prevention in the Early Gastric Cancer Patients
Status: RECRUITING
Conditions: Aspirin|Gastric Cancer
Interventions: DRUG: Aspirin 100mg|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of Coronary Flow Reserve by Doppler Flow Wire in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention Differences Between the Loading Dose of Ticagrelor and Clopidogrel
Status: UNKNOWN
Conditions: Acute Coronary Syndrome:|Non ST Elevation Myocardial Infarction|ST Elevation Myocardial Infarction|Unstable Angina
Interventions: PROCEDURE: Assessment of Coronary Flow Reserve|PROCEDURE: Percutaneous coronary intervention|DRUG: ticagrelor loading|DRUG: Clopidogrel loading
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tranexamic Acid in Debridement Surgery of Burns on the Volume of Bleeding in Transfusion Requirements
Status: RECRUITING
Conditions: Burns
Interventions: DRUG: Tranexamic acid|OTHER: 0.9% isotonic saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of S-3304 in Patients With Locally Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer|Lung Cancer|Stage IIIA Non Small Cell Lung Cancer|Stage IIIB Non Small Cell Lung Cancer
Interventions: DRUG: S-3304|OTHER: Chemo-irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Study Between Two Techniques for Correction of Upper Lid Retraction in Patients With Grave's Orbitopathy
Status: UNKNOWN
Conditions: Graves Ophthalmopathy
Interventions: PROCEDURE: blepharotomy|PROCEDURE: posterior approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Non-Randomized, Open-Label, Single-Dose Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [PF 01913539] In Subjects With Severely-Impaired And Normal Renal Function
Status: COMPLETED
Conditions: Alzheimer's Disease|Huntington's Disease
Interventions: DRUG: Dimebon|DRUG: Dimebon
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT