pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Combination Followed by Maintenance Chemotherapy Versus CDK4/6 Inhibitor Combined With Endocrine Therapy for HR Low/HER2-negative Advanced Breast Cancer: a Prospective, Randomized, Open-label Phase Ⅱ Clinical Trial
Status: RECRUITING
Conditions: Advanced Breast Cancer|Treatment|HR Low/HER2 Negative
Interventions: DRUG: Experimental: chemotheyapy|DRUG: Active Comparator: endocrine therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ω3 LCPUFAs for Healthy Growth and Development of Infants and Young Children in Southwest Ethiopia
Status: COMPLETED
Conditions: Child Malnutrition
Interventions: DIETARY_SUPPLEMENT: Fish powder corn-soy blend'+ Fish oil capsule.|DIETARY_SUPPLEMENT: Fish powder corn-soy blend + corn oil capsule.|DIETARY_SUPPLEMENT: Corn-soy blend + fish oil capsule.|DIETARY_SUPPLEMENT: Corn-soy blend + corn oil capsule.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Endoscopic Evaluation of Upper Gastrointestinal (GI) Mucosal Damage Induced by PL-2200 Versus Aspirin in Healthy Volunteers
Status: COMPLETED
Conditions: Upper Gastrointestinal Mucosal Damage
Interventions: DRUG: acetylsalicylic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Morphine Versus Morphine-promethazine Combination for Acute Low Back Pain Relief in the Adult Emergency Department
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: DRUG: Morphine-Promethazine|DRUG: morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality for the Education of Cancer Patients Undergoing Radiation Therapy
Status: TERMINATED
Conditions: Malignant Neoplasm
Interventions: OTHER: Educational Intervention|OTHER: Educational Intervention|OTHER: Educational Intervention|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Antiviral Efficacy of Switching to ETV Plus TDF
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: Group A (Zeffix, Sebivo, Hepsera)|DRUG: Group B (Baraclude, Viread)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fed Study of Topiramate Sprinkle Capsules 25 mg and Topamax® Sprinkle Capsules 25 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Topiramate Sprinkle Capsules 25 mg|DRUG: Topamax® Sprinkle Capsules 25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Outcomes of Endoscopic Resection for Treating WHYX Lesion
Status: COMPLETED
Conditions: WHYX Lesion|Extremely Well Differentiated Intestinal-type Adenocarcinoma
Interventions: PROCEDURE: WHYX cancer group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia
Status: SUSPENDED
Conditions: Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Acute Myeloid Leukemia|Chronic Myelomonocytic Leukemia|Myelodysplastic Syndrome With Excess Blasts|Recurrent Acute Myeloid Leukemia|Refractory Acute Lymphoblastic Leukemia|Recurrent Acute Lymphoblastic Leukemia|Recurrent Mixed Phenotype Acute Leukemia|Refractory Acute Myeloid Leukemia|Refractory Mixed Phenotype Acute Leukemia|Mixed Phenotype Acute Leukemia
Interventions: DRUG: Cyclosporine|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|DRUG: Mycophenolate Mofetil|PROCEDURE: Peripheral Blood Stem Cell Transplantation|OTHER: Pharmacological Study|RADIATION: Pretargeted Radioimmunotherapy|RADIATION: Total-Body Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Center Study to Evaluate Ticagrelor Mechanism of Action in Inhibiting Juvenile Platelet ADP Response
Status: WITHDRAWN
Conditions: Diabetes Mellitus
Interventions: DRUG: Ticagrelor|DRUG: Prasugrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 1 Dose-Escalation Study in Advanced Solid Tumors, Lymphomas or Multiple Myeloma
Status: COMPLETED
Conditions: Malignant Solid Tumor|Lymphomas|Multiple Myeloma
Interventions: BIOLOGICAL: AV-299|BIOLOGICAL: AV-299 + erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Handwashing: Drying With One or Two Surgical Towels
Status: RECRUITING
Conditions: Hand Hygiene|Surgical Wound Infection|Healthcare Associated Infection|Medical Errors
Interventions: OTHER: Drying procedure after surgical handwashing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety of Undenatured Collagen Type II (UCII) Supplement in Healthy Volunteer
Status: UNKNOWN
Conditions: Health, Subjective
Interventions: DIETARY_SUPPLEMENT: undenatured collagen type II (UCII) supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Transoral Robotic Surgery in Treating Patients With Benign or Stage I-IV Head and Neck Cancer
Status: TERMINATED
Conditions: Recurrent Adenoid Cystic Carcinoma of the Oral Cavity|Recurrent Lymphoepithelioma of the Nasopharynx|Recurrent Lymphoepithelioma of the Oropharynx|Recurrent Mucoepidermoid Carcinoma of the Oral Cavity|Recurrent Squamous Cell Carcinoma of the Hypopharynx|Recurrent Squamous Cell Carcinoma of the Larynx|Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity|Recurrent Squamous Cell Carcinoma of the Nasopharynx|Recurrent Squamous Cell Carcinoma of the Oropharynx|Recurrent Verrucous Carcinoma of the Larynx|Recurrent Verrucous Carcinoma of the Oral Cavity|Stage I Adenoid Cystic Carcinoma of the Oral Cavity|Stage I Lymphoepithelioma of the Nasopharynx|Stage I Lymphoepithelioma of the Oropharynx|Stage I Mucoepidermoid Carcinoma of the Oral Cavity|Stage I Squamous Cell Carcinoma of the Hypopharynx|Stage I Squamous Cell Carcinoma of the Larynx|Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage I Squamous Cell Carcinoma of the Nasopharynx|Stage I Squamous Cell Carcinoma of the Oropharynx|Stage I Verrucous Carcinoma of the Larynx|Stage I Verrucous Carcinoma of the Oral Cavity|Stage II Adenoid Cystic Carcinoma of the Oral Cavity|Stage II Lymphoepithelioma of the Nasopharynx|Stage II Lymphoepithelioma of the Oropharynx|Stage II Mucoepidermoid Carcinoma of the Oral Cavity|Stage II Squamous Cell Carcinoma of the Hypopharynx|Stage II Squamous Cell Carcinoma of the Larynx|Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage II Squamous Cell Carcinoma of the Nasopharynx|Stage II Squamous Cell Carcinoma of the Oropharynx|Stage II Verrucous Carcinoma of the Larynx|Stage II Verrucous Carcinoma of the Oral Cavity|Stage III Adenoid Cystic Carcinoma of the Oral Cavity|Stage III Lymphoepithelioma of the Nasopharynx|Stage III Lymphoepithelioma of the Oropharynx|Stage III Mucoepidermoid Carcinoma of the Oral Cavity|Stage III Squamous Cell Carcinoma of the Hypopharynx|Stage III Squamous Cell Carcinoma of the Larynx|Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage III Squamous Cell Carcinoma of the Nasopharynx|Stage III Squamous Cell Carcinoma of the Oropharynx|Stage III Verrucous Carcinoma of the Larynx|Stage III Verrucous Carcinoma of the Oral Cavity|Stage IV Adenoid Cystic Carcinoma of the Oral Cavity|Stage IV Lymphoepithelioma of the Nasopharynx|Stage IV Lymphoepithelioma of the Oropharynx|Stage IV Mucoepidermoid Carcinoma of the Oral Cavity|Stage IV Squamous Cell Carcinoma of the Hypopharynx|Stage IV Squamous Cell Carcinoma of the Larynx|Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IV Squamous Cell Carcinoma of the Nasopharynx|Stage IV Squamous Cell Carcinoma of the Oropharynx|Stage IV Verrucous Carcinoma of the Larynx|Stage IV Verrucous Carcinoma of the Oral Cavity
Interventions: PROCEDURE: transoral robotic surgery|OTHER: laboratory biomarker analysis|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alpha Radiation Emitters Device for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia (DaRT)
Status: ACTIVE_NOT_RECRUITING
Conditions: Skin Cancer|Mucosal Neoplasm of Oral Cavity|Soft Tissue Neoplasm
Interventions: DEVICE: Radiation: Diffusing Alpha Radiation Emitters Therapy (DaRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of Using Seraffix LTB - System for Excisional Biopsy Wounds Closure
Status: TERMINATED
Conditions: Dehiscence, Surgical Wound
Interventions: DEVICE: Seraffix LTB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Behavior Screening, Brief Intervention and Referral to Treatment (SBIRT) Model of Drug Abuse in Primary Care
Status: WITHDRAWN
Conditions: Drug Abuse
Interventions: BEHAVIORAL: MB-SBIRT (multiple behavior screening, brief intervention and referral to treatment) Online Program Brief|BEHAVIORAL: MB-SBIRT (multiple behavior screening, brief intervention and referral to treatment) Online Program Extended Length|BEHAVIORAL: MB-SBIRT (multiple behavior screening, brief intervention and referral to treatment) Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nicotine Differences in Smokers
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: DRUG: 0.05, 0.025, and 0.0125 mg nicotine/pulse of nicotine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Prostate Cancer Study In Men Who Have Failed First-Line Androgen Deprivation Therapy
Status: COMPLETED
Conditions: Neoplasms, Prostate
Interventions: DRUG: dutasteride|DRUG: placebo|DRUG: bicalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combined On-demand Sildenafil Citrate and Tramadol Hydrochloride for Treatment of Premature Ejaculation
Status: UNKNOWN
Conditions: Premature Ejaculation
Interventions: DRUG: Sildenafil 50 mg|DRUG: Placebo|DRUG: Tramadol Hydrochloride 100 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pycnogenol® in Post-COVID-19 Condition
Status: ACTIVE_NOT_RECRUITING
Conditions: Post COVID-19 Condition|Long COVID
Interventions: DRUG: Pycnogenol®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SoftHand Comparison Study
Status: ENROLLING_BY_INVITATION
Conditions: Upper Extremity Injury|Upper Extremity Deformities, Congenital|Amputation, Traumatic|Amputation, Congenital
Interventions: DEVICE: SoftHand Pro|DEVICE: Ossur i-Limb
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Tolerance of Long-Term Therapy With Intravenous Cytovene (Ganciclovir Sodium) for Cytomegalovirus Retinitis in Persons With AIDS
Status: COMPLETED
Conditions: Cytomegalovirus Retinitis|HIV Infections
Interventions: DRUG: Zidovudine|DRUG: Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Position for Ultrasound Guided Lumbar Plexus and Sciatic Nerve Block
Status: COMPLETED
Conditions: Lower Limb Surgery
Interventions: PROCEDURE: SGPP|PROCEDURE: SGTPP|PROCEDURE: SGLP|PROCEDURE: SGTLP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of 5-azacitidine and Lenalidomide in Myelodysplastic Syndromes (MDS) or Acute Myelogenous Leukemia (AML) Myelodysplastic Syndromes
Status: TERMINATED
Conditions: Myelodysplastic Syndromes|Acute Myelogenous Leukemia
Interventions: DRUG: Azacitidine|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Farmed Fish Human Intervention Study
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: OTHER: High PUFA Salmon Fillets|OTHER: Sustainable PUFA salmon|OTHER: No salmon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Alendronate Sodium /Vitamin D3 Combination Tablets(FOSAMAX PLUS) Versus Calcitriol in the Treatment of Osteoporosis in Postmenopausal Women in China (MK-0217A-264)
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal
Interventions: DRUG: alendronate 70-mg/vitamin D3 5600 IU combination tablet (Fosamax Plus)|DRUG: Calcitriol|DIETARY_SUPPLEMENT: Calcium 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Nicotine Uptake and Biomarkers in Smokers Using mybluTM Electronic Cigarettes
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: Myblu variant A|OTHER: Myblu variant B|OTHER: Myblu variant C|OTHER: Myblu variant D|OTHER: Myblu variant E|OTHER: Myblu variant F|OTHER: Myblu variant G|OTHER: Myblu variant H
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Application of PCSK9 Inhibitors in Patients With Heterozygous Familial Hypercholesterolemia
Status: UNKNOWN
Conditions: Efficacy and Safety|Heterozygous Familial Hypercholesterolemia|PCSK9
Interventions: BIOLOGICAL: protein convertase subtilisin/kexin type 9 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Radium 223 in Radioactive Iodine Refractory Bone Metastases From Differentiated Thyroid Cancer
Status: COMPLETED
Conditions: Thyroid Cancer
Interventions: RADIATION: Radium 223
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kisspeptin Influence on Glucose Homeostasis
Status: COMPLETED
Conditions: Impaired Glucose Tolerance|Hypogonadism
Interventions: DRUG: kisspeptin 112-121|OTHER: Insulin Resistance Test|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Supporting Methods in Cardiovascular Diseases Rehabilitation
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Artery Disease|Mood Disorders|Depressive Symptoms|Anxiety|Stress
Interventions: BEHAVIORAL: Cardiac rehabilitation|BEHAVIORAL: Relaxation-therapeutic recordings|DEVICE: Virtual reality therapy|BEHAVIORAL: Schultz Autogenic Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of PTW-002 in Patients With Dominant or Recessive Dystrophic Epidermolysis Bullosa Due to Mutation(s) in Exon 73 of the COL7A1 Gene
Status: NOT_YET_RECRUITING
Conditions: Dystrophic Epidermolysis Bullosa
Interventions: DRUG: PTW-002 10 mg/g gel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Immunogenicity and Efficacy Against of a Combined Malaria Vaccine in Healthy Malaria-naïve Adults
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: Crucell's replication deficient adenovirus type 35 circumsporozoite malaria vaccine (Ad35.CS.01)|BIOLOGICAL: GSK Biologicals' malaria vaccine 257049 (2 doses)|BIOLOGICAL: GSK Biologicals' malaria vaccine 257049 (3 doses)|OTHER: Sporozoite challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PK Study on Ready-to-Use Injection (VSLI-RTU) 1 Vial & 3 Vial Formulation Marqibo® in Hematological Malignant Patients
Status: UNKNOWN
Conditions: Hematologic Diseases
Interventions: DRUG: Vincristine Sulfate Liposome|COMBINATION_PRODUCT: CHOP|COMBINATION_PRODUCT: R-CHOP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Pirfenidone in Participants With Systemic Sclerosis-Related Interstitial Lung Disease (SSc-ILD) (LOTUSS)
Status: COMPLETED
Conditions: Systemic Sclerosis
Interventions: DRUG: Pirfenidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Powerball System in People With Multiple Sclerosis
Status: COMPLETED
Conditions: Neurologic Disorder|Multiple Sclerosis
Interventions: DEVICE: NDS-Powerball®,|OTHER: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Applied Four Times Daily in Subjects With Acute Ankle Sprain
Status: COMPLETED
Conditions: Acute Ankle Sprain
Interventions: DRUG: Diclofenac Sodium|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-Molecular-Weight Heparin Injection in Stroke Patients
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: The Effect of Different Pressure Periods on Bruising and Pain After Subcutaneous Heparin Injection Applied to the Upper Arm Region
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Compassionate-Use of 4% T-EDTA Lock Solution for Central Venous Lines of Pediatric PN Patients
Status: ENROLLING_BY_INVITATION
Conditions: Central Line Complication|Central Line-associated Bloodstream Infection (CLABSI)
Interventions: DEVICE: Tetrasodium EDTA Catheter Lock Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Interaction Between High Dose Sulfamethoxazole/Trimethoprim and Zidovudine
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Sulfamethoxazole-Trimethoprim|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extended Release Niacin and Fenofibrate for the Treatment of Atherogenic Dyslipidemia in Obese Females
Status: COMPLETED
Conditions: Atherogenic Dyslipidemia|Obesity Associated Disorder
Interventions: OTHER: Therapeutic Lifestyle Changes|OTHER: Placebo|DRUG: Fenofibrate|DIETARY_SUPPLEMENT: Wax Matrix Extended Release Niacin (WMER Niacin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: SERF VT Ablation Early Feasibility Study (EFS)
Status: COMPLETED
Conditions: Ventricular Tachycardia|Arrythmia|Heart Diseases|Cardiovascular Diseases
Interventions: DEVICE: Saline Enhanced Radiofrequency (SERF) ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Henagliflozin and Continuous Subcutaneous Insulin Infusion in T2DM
Status: RECRUITING
Conditions: Type2diabetes
Interventions: DRUG: Henagliflozin|DEVICE: Continuous Subcutaneous Insulin Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Subjects to Assess Drug Availability of 4 Different Formulations of Verinurad and Allopurinol
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Verinurad prolonged release HPMC capsule|DRUG: Allopurinol Tablet|DRUG: Verinurad/Allopurinol FDC Capsule|DRUG: Verinurad prolonged release gelatin Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Combination of Fenofibrate and Simvastatin Versus Atorvastatin
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DRUG: fenofibrate / simvastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraurethral Lidocaine After Endourology Procedures
Status: TERMINATED
Conditions: Dysuria
Interventions: DRUG: Lidocaine Jet Injector|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Augmenting Zyprexa With Naltrexone to Ameliorate Metabolic Side-Effects
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders
Interventions: DRUG: naltrexone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gut Microbiota, SCFAs and Glucolipid Metabolism in Pregnant Women With Abnormal Fetal Size and Their Newborns
Status: UNKNOWN
Conditions: Fetal Growth Restriction|Gut Microbiota|Fetal Macrosomia|Glucolipid Metabolism
Interventions: OTHER: test gut microbiota, SCFAs and glucolipid metabolism and insulin sensitivity
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Two Doses of Duloxetine & Amitriptyline in Interstitial Lung Disease-related Cough
Status: RECRUITING
Conditions: Interstitial Lung Disease
Interventions: DRUG: Amitriptyline 25 MG|DRUG: Amitriptyline 50 MG|DRUG: Duloxetine 30 MG|DRUG: Duloxetine 60 MG|DRUG: Placebo 30 MG|DRUG: Placebo 60 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Alzheimer Disease and Diminution of the Three Macular Nervous Retinal Layers
Status: COMPLETED
Conditions: Optical Coherence Tomography|Optical Coherence Tomography Angiography|Retinal Thickening|Alzheimer Disease|Lewy Body Disease|Retina|Cortical Atrophy|Retinal Nerve Fibres Layer
Interventions: DIAGNOSTIC_TEST: Optical coherence tomography (OCT)|DIAGNOSTIC_TEST: Optical coherence tomograpohy angiography (OCTA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Internal and Predictive Validity of Epworth Sleepiness Scale to Evaluate Vigilance of Patient Treated for Obstructive Sleep Apnea Syndrome.
Status: COMPLETED
Conditions: Obstructive Sleep Apnea Syndrome
Interventions: DIAGNOSTIC_TEST: Epworth Sleepiness Scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: WSD0922-FU for the Treatment of Glioblastoma, Anaplastic Astrocytoma, or Non-small Cell Lung Cancer With Central Nervous System Metastases
Status: RECRUITING
Conditions: Anaplastic Astrocytoma, IDH-Wildtype|Glioblastoma, IDH-Wildtype|Metastatic Lung Non-Small Cell Carcinoma|Metastatic Malignant Neoplasm in the Central Nervous System
Interventions: PROCEDURE: Biospecimen Collection - blood samples|PROCEDURE: Biospecimen Collection - CSF samples|PROCEDURE: Computed Tomography|DRUG: EGFR/EGFRvIII Inhibitor WSD0922-FU|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: D-cycloserine (DCS) Pretreatment + CBT + Nicotine Replacement Therapy for Smoking Cessation (DCS)
Status: TERMINATED
Conditions: Nicotine Dependence|Smoking Cessation
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|DRUG: Nicotine Replacement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Genetic Alterations in Key Genes in the Kynurenine Pathway on Suicidal Behavior
Status: UNKNOWN
Conditions: Kynureninase|Polymorphism|Suicidal Behavior
Interventions: GENETIC: Analysis of Single nucleotide polymorphisms in each group.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men
Status: COMPLETED
Conditions: Hypogonadism|Cardiovascular Diseases
Interventions: DRUG: AndroGel®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neochordae Technique in Mitral Valve Repair
Status: UNKNOWN
Conditions: Mitral Valve Prolapse|Mitral Regurgitation
Interventions: PROCEDURE: adjustable neochordae Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of GWP42003 on Liver Fat Levels in Participants With Fatty Liver Disease
Status: COMPLETED
Conditions: Fatty Liver
Interventions: DRUG: GWP42003 200 mg/day Dose|DRUG: GWP42003 400 mg/day Dose|DRUG: GWP42003 800 mg/day Dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treating Drivers of Suicide Using Jaspr Health
Status: NOT_YET_RECRUITING
Conditions: Suicide|Suicide, Attempted|Suicidal Ideation|Alcohol Use Disorder|Alcoholism|Alcohol Abuse|Screening and Brief Interventions
Interventions: DEVICE: Jaspr2.0|DEVICE: Active-Control app + electronic wellness resources brochure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Health Effects of Secondhand Smoke Exposure in Outdoor Smoking Areas in Patients With COPD and Asthma ( TackSHSWP5 )
Status: COMPLETED
Conditions: COPD|Asthma|Second Hand Tobacco Smoke
Interventions: OTHER: Exposure to secondhand tobacco smoke
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lymph Node Identification in Skin Malignancy Using ICG Transcutaneously Study
Status: COMPLETED
Conditions: Malignant Melanoma|Merkel Cell Carcinoma
Interventions: DIAGNOSTIC_TEST: Visionsense™ VS3 - Stereoscopic High Definition Visualisation System (VS3-3DHD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nurses-driven, Capnography-guided Protocol Weaning From the Mechanical Ventilation at Bedside: A Feasibility Study
Status: RECRUITING
Conditions: Weaning From Mechanical Ventilation
Interventions: PROCEDURE: Weaning protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Positron Emission Tomography (PET) Study to Examine the Brain Binding Properties of a Novel Radioactive Compound [11C]-PXT012253 in Healthy Subjects
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: [11C]PXT012253
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin A for the Treatment of Chemotherapy Induced Peripheral Neuropathy
Status: RECRUITING
Conditions: Peripheral Neuropathy Due to Chemotherapy
Interventions: DRUG: IncobotulinumtoxinA (Xeomin®, Merz) (INA)|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: IGHID 12219 - A Brief Alcohol Intervention for PrEP Use Among MSM in Vietnam
Status: RECRUITING
Conditions: HIV Prevention|Unhealthy Alcohol Use
Interventions: BEHAVIORAL: The Brief Alcohol Intervention (BAI): Behavioral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Muscle Fiber Fragments for Improved Function of Rotator Cuff Musculature Following Rotator Cuff Repair
Status: RECRUITING
Conditions: Rotator Cuff
Interventions: OTHER: Muscle Fiber Fragments (MFFs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Potential Efficacy of MS-20 In Combination With Pembrolizumab for the Treatment of NSCLC
Status: UNKNOWN
Conditions: NSCLC Stage IV
Interventions: DRUG: MS-20|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: the Evaluation of the Efficacy of TCI66207 on the Skin.
Status: COMPLETED
Conditions: Skin Diseases
Interventions: DIETARY_SUPPLEMENT: TCI66207 Essence|DIETARY_SUPPLEMENT: Placebo Essence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of KP-100IT in Acute Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: DRUG: KP-100IT|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of CC VS Aerobic Exercise for Strengthening and Improving QOL in Post Stroke Patients
Status: RECRUITING
Conditions: Stroke
Interventions: DIAGNOSTIC_TEST: Closed Chain|DIAGNOSTIC_TEST: Aerobic Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Comparison of the Effects of Extended Release Tacrolimus (Advagraf®) vs. Immediate Release Tacrolimus (Prograf®) on Kidney Function in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Advagraf®|DRUG: Prograf®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: CAR-T Cell Immunotherapy in MUC1 Positive Solid Tumor
Status: UNKNOWN
Conditions: Malignant Glioma of Brain|Colorectal Carcinoma|Gastric Carcinoma
Interventions: BIOLOGICAL: anti-MUC1 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zinc With Chloroquine/Hydroxychloroquine in Treatment of COVID-19
Status: COMPLETED
Conditions: COVID
Interventions: DRUG: Chloroquine or hydroxychloroquine|DRUG: zinc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Dapagliflozin on Insulin Secretion and Insulin Sensitivity in Patients With Prediabetes
Status: COMPLETED
Conditions: Prediabetes|Impaired Fasting Glucose|Impaired Glucose Tolerance
Interventions: DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Daily-Dose Consensus Interferon and Ribavirin: Efficacy of Combined Therapy
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Daily Infergen (Interferon Alfacon-1, CIFN) (9 or 15 µg) + Ribavirin (1000-1200 mg, based on body weight) PO Daily for up to 48 wks
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Saltikva for Metastatic Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: Salmonella-IL2|DRUG: FOLFIRINOX Alone (Historical Controls)|DRUG: Gemcitabine/Abraxane Alone (Historical Controls)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mirabegron Treatment on Patients With Overactive Bladder Syndrome in Taiwan
Status: COMPLETED
Conditions: Urinary Incontinence|Overactive Bladder Syndrome
Interventions: DRUG: Mirabegron 25mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing In-hospital Use of Evidence-based Therapies for Patients With Cardio-Renal-Metabolic Disease
Status: RECRUITING
Conditions: Heart Failure|Type 2 Diabetes|Chronic Kidney Diseases
Interventions: OTHER: Virtual Consult Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of 48 Weeks Versus 24 Weeks of Therapy With Peg-Intron/Ribavirin in Patients With Chronic Hepatitis C, Genotype 3 (Study P04143)(TERMINATED)
Status: TERMINATED
Conditions: Hepatitis C, Chronic
Interventions: BIOLOGICAL: Peginterferon alfa-2b|BIOLOGICAL: Peginterferon alfa-2b|DRUG: Ribavirin|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventive Effect of I-Fiber Pearl on Body Weight and Body Fat in Obese Adults
Status: RECRUITING
Conditions: Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: I-Fiber Pearl|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Evaluation of Neobianacid® in GERD and EPS
Status: COMPLETED
Conditions: GERD|EPS
Interventions: DEVICE: Neobianacid®|DRUG: Omeprazole 20mg|OTHER: Neobianacid® placebo|OTHER: Omeprazole placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Safety, Tolerability, and Pharmacokinetics of Orally Administered GCC4401C in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Male
Interventions: DRUG: GCC-4401|DRUG: GCC-4401C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Amplifying Sensation in Underactive Bladder
Status: RECRUITING
Conditions: Urinary Bladder, Underactive
Interventions: DEVICE: Neurometer Neurotron CPT|PROCEDURE: Cystometry|PROCEDURE: Pressure-flow study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Two Methods of Continuous Positive Airway Pressure (CPAP) to Support Successful Extubation of Infants of Birth Weights ≤ 1500 Grams (C2CPAP)
Status: UNKNOWN
Conditions: Premature Birth|Respiratory Insufficiency
Interventions: DEVICE: Infant Flow System|DEVICE: Bubble CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers of Kidney Function in Transplant Medicine
Status: RECRUITING
Conditions: Acute Kidney Injury
Interventions: DIAGNOSTIC_TEST: Laboratory values - baseline|OTHER: Medical information 12 hours before organ harvesting|DIAGNOSTIC_TEST: Laboratory values - 12 hours after reperfusion|DIAGNOSTIC_TEST: Laboratory values - 48 hours after reperfusion|DIAGNOSTIC_TEST: Laboratory values - 7 days after reperfusion|DIAGNOSTIC_TEST: Laboratory values - 90 days after reperfusion|OTHER: Medical information during organ harvesting/transplantation|PROCEDURE: Organ harvesting|PROCEDURE: Organ transplantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Risperidone for the Treatment of Huntington's Disease Involuntary Movements
Status: COMPLETED
Conditions: Huntington Disease|Chorea
Interventions: DRUG: Risperidone|DEVICE: BioStamp nPoint device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CAF With or Without CTG for the Treatment of Single Maxillary Gingival Recession With NCCL
Status: COMPLETED
Conditions: Gingival Recession
Interventions: PROCEDURE: CAF|PROCEDURE: CAF + CTG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy and Safety of Oral Treprostinil in Subjects With Pulmonary Hypertension (PH) Associated With Sickle Cell Disease (SCD)
Status: WITHDRAWN
Conditions: Pulmonary Hypertension Associated With Sickle Cell Disease
Interventions: DRUG: Oral Treprostinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Combination Therapy With Amivantamab and Cetrelimab in Participants With Metastatic Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Cetrelimab|DRUG: Amivantamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determining Dose of Regadenoson Most Likely to Transiently Alter the Integrity of the Blood-Brain Barrier in Patients With High Grade Gliomas
Status: TERMINATED
Conditions: High Grade Glioma|Anaplastic Astrocytoma|Anaplastic Oligodendroglioma|Glioblastoma
Interventions: DRUG: Regadenoson 0.05mg|DRUG: Regadensoson 0.1mg|DRUG: Regadensoson 0.2mg|DRUG: Regadensoson 0.4mg|DRUG: Regadensoson 0.7mg|DRUG: Regadensoson 1.0mg|DRUG: Regadensoson 1.4mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab Versus Observation as Maintenance Therapy in Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Assessment of Potential Interactions Between IV Methamphetamine and Osmotic-Release Methylphenidate (OROS-MPH)
Status: COMPLETED
Conditions: Methamphetamine Dependence|Methamphetamine Abuse
Interventions: DRUG: OROS-MPH|DRUG: OROS-MPH|DRUG: OROS-MPH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Neutrexin Plus Leucovorin in the Treatment of Pneumocystis Carinii Pneumonia (PCP)
Status: COMPLETED
Conditions: Pneumonia, Pneumocystis Carinii|HIV Infections
Interventions: DRUG: Trimetrexate glucuronate|DRUG: Leucovorin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Antioxidants and Oxidants in Malnourished Children
Status: COMPLETED
Conditions: Protein-energy Malnutrition|Kwashiorkor|Marasmus
Interventions: DIETARY_SUPPLEMENT: sulfur amino acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Peripapillary Atrophy to Diagnose Glaucoma in High Myopia
Status: NOT_YET_RECRUITING
Conditions: Myopia|Refractive Errors|Eye Diseases|Glaucoma, Primary Open Angle|Peripapillary Atrophy
Interventions: DIAGNOSTIC_TEST: OCT imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: E2022 Patch Formulation Single Dose Phase I Study
Status: COMPLETED
Conditions: Japanese Healthy Male Adult Volunteers
Interventions: DRUG: E2022|DRUG: E2022|DRUG: E2022|DRUG: E2022|DRUG: E2022
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of AMG 337 in MET Amplified Gastric/Esophageal Adenocarcinoma or Other Solid Tumors
Status: TERMINATED
Conditions: Stomach Neoplasms
Interventions: DRUG: AMG 337
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Erigeron Injection on Acute Cerebral Infarction Serum VEGF, MMP-9 and EPC Levels
Status: UNKNOWN
Conditions: Cerebral Infarction
Interventions: DRUG: Erigeron Injection|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Probiotic or Fecal Microbiota Transplantation (FMT) on the Eradication of Rectal Multidrug-resistant Gram-negative Bacilli (MDR-GNB) Carriage (PROFTMDECOL)
Status: UNKNOWN
Conditions: CARRIER STATE
Interventions: DIETARY_SUPPLEMENT: PROBIOTIC|DIETARY_SUPPLEMENT: FMT REGIMEN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy Study of GSK2269557 Added to Standard Care in Subjects With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK2269557|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Comparison of Ultrasound Versus Radiofrequency Denervation in Patients With Therapy Resistant Hypertension
Status: COMPLETED
Conditions: Therapy Resistant Hypertension
Interventions: DEVICE: Radiofrequency denervation of the main renal arteries|DEVICE: Radiofrequency denervation of renal arteries and branches|DEVICE: Ultrasound denervation of the main renal arteries
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound to Predict a Pediatric Difficult Airway and Obstructive Sleep Apnea Syndrome in Children
Status: WITHDRAWN
Conditions: Difficult Airway|Obstructive Sleep Apnea
Interventions: PROCEDURE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Latinos Understanding the Need for Adherence in Diabetes Using E-Health
Status: RECRUITING
Conditions: Type 2 Diabetes|Glycemic Control|Psychological Distress
Interventions: BEHAVIORAL: LUNA Care Coordination|BEHAVIORAL: LUNA Behavioral Health|BEHAVIORAL: Health Education Videos|BEHAVIORAL: Virtual Integrated Visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Repeat Insult Patch Test (RIPT) Study Evaluating the Sensitization Potential of Topical SM04755 Solution in Healthy Volunteers
Status: COMPLETED
Conditions: Tendinopathy
Interventions: DRUG: SM04755|OTHER: Vehicle|OTHER: White Petrolatum|OTHER: Sodium lauryl sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarkers of Ischemia: Xanthine, Hypoxanthine and Inosine Levels During Carotid Stenting Procedures
Status: COMPLETED
Conditions: Identify the Presence of a Marker of Ischemia/Hypoperfusion of the Brain Via Peripheral Blood|Ischemia/Hypoperfusion of Brain
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Visual Telerehabilitation in Children, Adolescents and Young Adults With Hemianopsia Consecutive to a Brain Tumour
Status: NOT_YET_RECRUITING
Conditions: Hemianopsia
Interventions: DEVICE: Audiovisual stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Surveys, Blood Testing, and Fibroscan in Screening for Liver Fibrosis and Liver Cirrhosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Liver and Intrahepatic Bile Duct Carcinoma
Interventions: OTHER: Clinical Evaluation|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Liver Ultrasonographic Elastography|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING