pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Contribution of High-throughput Exome Sequencing in the Diagnosis of the Cause Fetal Polymalformation Syndromes
Status: COMPLETED
Conditions: Fetuses With at Least 2 Malformations, and no Diagnosis After Fetopathological and Radiological Examinations
Interventions: OTHER: Sample of a fragment of fetal tissue|OTHER: Parent's blood samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Trial of Virtual and In-person STEP2
Status: NOT_YET_RECRUITING
Conditions: Oncology
Interventions: BEHAVIORAL: Virtual and in-person Symptom screening with Targeted Early Palliative care (STEP2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Different Postoperative Analgesics Use After Ureteroscopy
Status: UNKNOWN
Conditions: Post Operative Pain|Ureteroscopy|Ureter Stone
Interventions: DRUG: Opioid|DRUG: Non-Opioid Analgesic|DRUG: Non-Opioid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Methotrexate to Treat Sarcoid-associated Uveitis
Status: TERMINATED
Conditions: Sarcoid-associated Uveitis|Ocular Sarcoidosis|Macular Edema
Interventions: DRUG: Methotrexate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Urgent (<24 Hours) Versus Early (24 to 48 Hours) ERCP for Patients With Mild and Moderate Acute Cholangitis
Status: RECRUITING
Conditions: Acute Cholangitis
Interventions: PROCEDURE: ERCP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemotherapy and Radical Surgery in Stage IIB Cervical Cancer
Status: UNKNOWN
Conditions: Cervical Carcinoma Stage IIB
Interventions: RADIATION: Concurrent chemoirradiation|DRUG: Paclitaxel|PROCEDURE: Radical Surgery|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MucoLox Formulation to Mitigate Mucositis Symptoms in Head/Neck Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Mucositis Oral|Head and Neck Cancer
Interventions: OTHER: MucoLox|OTHER: Sodium Bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Flecainide for Catecholaminergic Polymorphic Ventricular Tachycardia
Status: COMPLETED
Conditions: Catecholaminergic Polymorphic Ventricular Tachycardia
Interventions: DRUG: Flecainide Acetate|DRUG: Placebo|DRUG: Beta blocker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The EMPrint™ Ablate and RESect Study in Patients With Metastatic Lung Tumors (EMPRESS)
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DEVICE: Ablation|PROCEDURE: Surgical Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PARP Inhibitor With 177Lu-DOTA-Octreotate PRRT in Patients With Neuroendocrine Tumours
Status: RECRUITING
Conditions: Neuroendocrine Tumors
Interventions: DRUG: Talazoparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two Formulations and Concentrations of Epinastine Nasal Spray Versus Azelastine Nasal Solution for Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: epinastine 0.1%|DRUG: epinastine 0.1% with taste masking agent|DRUG: epinastine 0.2%|DRUG: epinastine 0.2% with taste masking agent|DRUG: azelastine 0.1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peripheral Intravenous Puncture Guided by Vascular Ultrasound
Status: COMPLETED
Conditions: Intravenous Puncture Assertivity|Intravenous Puncture Guided by Vascular Ultrasound|Intravenous Therapy Complications
Interventions: PROCEDURE: IV puncture guided by ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Open-Label Observational Pilot Study to Evaluate the Pharmacokinetics of Aripiprazole in Subjects With Bipolar 1 Disorder or Schizophrenia
Status: COMPLETED
Conditions: Bipolar 1 Disorder|Schizophrenia|Mental Disorder|Nervous System Disorders
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Healing of Rectal Anastomosis Sealed With a Concentrate Derived From the Patient's Blood, After Rectal Cancer Surgery
Status: COMPLETED
Conditions: Anastomotic Leak Rectum|Rectal Cancer|Anastomotic Leakage
Interventions: OTHER: Application of autologous fibrin matrix (Obsidian)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Glioblastoma Multiforme (GBM) Proton vs. Intensity Modulated Radiotherapy (IMRT)
Status: COMPLETED
Conditions: Brain Cancer
Interventions: RADIATION: IMPT|RADIATION: IMRT|BEHAVIORAL: Cognitive Tests|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erlotinib Alone or in Combination With Radiation Therapy in Treating Young Patients With Refractory or Relapsed Malignant Brain Tumors or Newly Diagnosed Brain Stem Glioma
Status: UNKNOWN
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: erlotinib hydrochloride|GENETIC: mutation analysis|GENETIC: polymorphism analysis|OTHER: laboratory biomarker analysis|OTHER: pharmacological study|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Bed Availability and Cognitive Load on Intensive Care Unit Bed Allocation: a Vignette-based Clinical Trial
Status: UNKNOWN
Conditions: There Are no Specific Conditions Under Study|This Study Evaluates the Clinical Decision-Making Associated With Intensive Care Units Rationing
Interventions: BEHAVIORAL: Increased cognitive load
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: tDCS and Bimanual Therapy for Children With Hemiplegic Cerebral Palsy
Status: RECRUITING
Conditions: Cerebral Palsy|Hemiplegic Cerebral Palsy|Spastic Hemiplegic Cerebral Palsy|Spastic Hemiparesis|Spastic Hemiplegia
Interventions: DEVICE: active transcranial direct current stimulation|BEHAVIORAL: bimanual training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tele-Rehabilitation Pilot Evaluation Study
Status: COMPLETED
Conditions: Fractures, Bone|Stroke|Lower Limb Joint Replacement (Hip or Knee)|Lower Limb Amputation|Pneumonia|Fall|Deconditioning|Musculoskeletal Conditions (e.g., Tendinitis, Capsulitis)
Interventions: BEHAVIORAL: Tele-rehabilitation|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Safety of Nivolumab and Ipilimumab in Subjects With Previously Untreated Advanced or Metastatic Renal Cell Cancer
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Efficacy Study of Combination Therapy of Everolimus and Low Dose Tacrolimus in Renal Allograft Recipients
Status: UNKNOWN
Conditions: Kidney; Complications, Allograft
Interventions: DRUG: Everolimus|DRUG: Tacrolimus|DRUG: Mycophenolic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Door to the Womb at Birth: Haptonomy
Status: COMPLETED
Conditions: Birth Outcome, Adverse|Self Efficacy|Memory Impairment|Pregnancy Related
Interventions: OTHER: Haptonomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hyperbaric Oxygen Therapy for Cognition in Diabetic Elderly at High Dementia Risk
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: HBOT intervention|DEVICE: Sham intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Sequential Immunization of Omicron Inactivated COVID-19 Vaccine and Prototype Inactivated COVID-19 Vaccine in Population Aged 18 Years Old and Above
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: Omicron COVID-19 Vaccine (Vero Cell), Inactivated|BIOLOGICAL: COVID-19 Vaccine (Vero Cell), Inactivated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: "Answers in Hours" A Randomized Controlled Trial Using Microbiome Metagenomics for Bile Duct Cultures
Status: ACTIVE_NOT_RECRUITING
Conditions: Benign Pancreatic Neoplasm|Malignant Pancreatic Neoplasm
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Laboratory Procedure|DEVICE: Nanopore Sequencing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dose Response and Safety Study of Topical Methotrexate for the Treatment of Fingernail Psoriasis
Status: UNKNOWN
Conditions: Fingernail Psoriasis
Interventions: DRUG: Methotrexate|DRUG: Methotrexate|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Trial to Determine Safety and Protective Efficacy of Sanaria PfSPZ Challenge With Concurrent Pyrimethamine Treatment That Inhibits Development of Asexual B...
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Chloroquine (CQ)|DRUG: Pyrimethamine (PYR)|BIOLOGICAL: Sanaria PfSPZ Challenge (NF54)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Atypical Antipsychotic Treatment Effect On Brain Function In Schizophrenia Measured By FMRI
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Risperidone|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase I Study of a Novel Tracer for Positron Emission Tomography "PET" Myocardial Perfusion Imaging "MPI"
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: OTHER: [11C]-DMDPA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Immunogenicity of RTS,S/AS02A, and RTS,S/AS01B Malaria Vaccines in Malaria-experienced Adults.
Status: COMPLETED
Conditions: Plasmodium Falciparum
Interventions: BIOLOGICAL: RTS, S/AS01B|BIOLOGICAL: RTS, S/AS02A|BIOLOGICAL: Rabipur (Rabies) Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Extracorporeal Photopheresis in Patients With Bronchiolitis Obliterans Syndrome (BOS) After Lung Transplantation
Status: TERMINATED
Conditions: Bronchiolitis Obliterans
Interventions: PROCEDURE: photopheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Strength Training on Executive Functions in Elderly People With Mild Cognitive Impairment
Status: UNKNOWN
Conditions: Strength Training|Executive Function
Interventions: OTHER: Effect of strength training on executive functions in elderly people with mild cognitive impairment.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Omnitram Pharmacokinetic Study In Healthy Volunteers
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Omnitram|DRUG: Tramadol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Forced Diuresis Versus Observation in Resolving Renal Failure After Haemofiltration in Critically Ill Patients
Status: TERMINATED
Conditions: Renal Failure|Critically Ill
Interventions: DRUG: Furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Iclusig® (Ponatinib) in Clinical Practice for the Treatment of Chronic Myeloid Leukemia or Ph+ Acute Lymphoblastic Leukemia in Belgium
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia|CML|Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia|Ph+ ALL
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Conversion From Total Intravenous Anesthesia Technique to Desflurane Anesthesia for Long Duration Neurosurgery
Status: UNKNOWN
Conditions: Patients Undergoing Elective Craniotomy
Interventions: DRUG: Propofol|DRUG: Desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: SkinTE™ in the Treatment of Diabetic Foot Wounds
Status: COMPLETED
Conditions: Diabetic Foot|Diabetic Foot Ulcer|Ulcer Foot
Interventions: OTHER: Human Autologous Homologous Skin Construct|OTHER: Additional Outer Dressing Applicaiton|OTHER: Offloading|OTHER: Fibracol Wound Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability of a Single-dose Administration of BIBW 2992 and Multiple-dose Administration of Ritonavir in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIBW 2992|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Oral Hygiene and Full Mouth Scaling on Metabolic Control in Patients With Type II Diabetes
Status: UNKNOWN
Conditions: Gingival Scaling|Metabolic Control
Interventions: PROCEDURE: Gingival scaling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of [11C]-Methionine PET/MRI in the Detection of Pituitary Adenomas Secreting ACTH and Causing Cushing's Disease
Status: COMPLETED
Conditions: Cushing's Disease
Interventions: OTHER: [11C]-Methionine PET/MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Home-Based Screening for Early Detection of Atrial Fibrillation in Primary Care Patients Aged 75 Years and Older
Status: COMPLETED
Conditions: Atrial Fibrillation|Hypertension
Interventions: DEVICE: Screening: Intervention - Atrial fibrillation screening (ZIO XT ECG monitor, Watch-BP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Vitamin A and Zinc: Prevention of Pneumonia (VAZPOP) Study
Status: COMPLETED
Conditions: Pneumonia|Diarrhea|Acute Upper Respiratory Tract Infections
Interventions: DRUG: Zinc (12.5 mg/day)|DRUG: vitamin A 10,000 IU per week
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Effect of Cartoon-assisted Visual/Auditory Distraction Method in Paediatric Dental Patients
Status: COMPLETED
Conditions: Behavior, Child
Interventions: BEHAVIORAL: Behavioral guidance|OTHER: Pain assessment|OTHER: Dental anxiety assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Three Different Latanoprost 0,005% Eyedrops in Subjects Affected by Primary Open Angle Glaucoma
Status: UNKNOWN
Conditions: Intraocular Pressure (IOP)|Tear Break-Up Time
Interventions: DRUG: IOPIZE© Latanoprost eyedrops|DRUG: GALAXIA© Latanoprost eyedrops|DRUG: Latanoprost RATIOPHARM© latanoprost eyedrops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Therapy With Abemaciclib + SOC ET vs. SOC ET in Clinical or Genomic High Risk, HR+/HER2- EBC
Status: RECRUITING
Conditions: Breast Cancer Female
Interventions: DRUG: Abemaciclib 50 MG; 150mg 1-0-1 per os
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fesoterodine for Amelioration of Autonomic Dysreflexia (AD) Following Spinal Cord Injury (SCI)
Status: COMPLETED
Conditions: Autonomic Dysreflexia
Interventions: DRUG: Fesoterodine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Aripiprazole in Healthy Adult Subjects Under Fasting Condition
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Aripiprazole 10 mg tablet|DRUG: Abilify® 10 mg tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of the Health Literacy of Our Patients Who Quit Smoking and Who Cannot Quit Smoking
Status: COMPLETED
Conditions: Smoking Cessation|Health Literacy
Interventions: BEHAVIORAL: Health literacy scale
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Residual Gastric Volume After the Ingestion of Supplements Containing Carbohydrates and Whey Protein
Status: COMPLETED
Conditions: Fasting|Gastric Stasis|Perioperative Complication|Safety Issues
Interventions: DIETARY_SUPPLEMENT: Gastric emptying after an oral supplement containing carbohydrates and whey protein|DIETARY_SUPPLEMENT: Overnight Fast
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Sertraline for Alcohol Dependence and Depression
Status: COMPLETED
Conditions: Alcoholism|Depression
Interventions: DRUG: naltrexone (Revia)|DRUG: sertraline (Zoloft)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Which is Better Between Single Chest Tube and Multiple Tubes Drainage in Primary Spontaneous Pneumothorax
Status: UNKNOWN
Conditions: Primary Spontaneous Pneumothorax
Interventions: PROCEDURE: single chest tube drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telehealth Cognitive Behavioral Therapy for Depression in Parkinson's Disease (PD)
Status: COMPLETED
Conditions: Depression|Parkinson's Disease
Interventions: BEHAVIORAL: TH-CBT|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perifosine and Docetaxel in Patients With Relapsed Epithelial Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Perifosine|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Pulsed Electromagnetic Field Stimulation on Localized Pediatric Osteomyelitis
Status: RECRUITING
Conditions: Osteomyelitis
Interventions: DEVICE: pulsed electromagnetic field|DRUG: Antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Thioctic Acid and Deprenyl in HIV-Infected Patients With Dementia
Status: COMPLETED
Conditions: Cognitive Disorders|HIV Infections
Interventions: DRUG: Thioctic acid|DRUG: Selegiline hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Explore the Papilocare Gel Efficacy to Repair the Cervico-vaginal Mucosa With Lesions Caused by HPV
Status: COMPLETED
Conditions: Human Papilloma Virus Infection|Human Papilloma Virus|Cervix Lesion
Interventions: DEVICE: Papilocare vaginal gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transversus Abdominis Plane Block Compared to Local Anesthetic Wound Infiltration in Gynecologic Oncology Surgery
Status: RECRUITING
Conditions: Analgesia|Surgery
Interventions: DRUG: TAP Anesthesia|DRUG: Surgeon-Initiated Local Anesthetic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Enhanced Outpatient Symptom Management to Reduce Acute Care Visits Due to Chemotherapy-Related Adverse Events
Status: RECRUITING
Conditions: Clinical Stage IV Esophageal Adenocarcinoma AJCC v8|Clinical Stage IV Esophageal Squamous Cell Carcinoma AJCC v8|Clinical Stage IV Gastric Cancer AJCC v8|Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8|Clinical Stage IVA Esophageal Squamous Cell Carcinoma AJCC v8|Clinical Stage IVA Gastric Cancer AJCC v8|Clinical Stage IVB Esophageal Adenocarcinoma AJCC v8|Clinical Stage IVB Esophageal Squamous Cell Carcinoma AJCC v8|Clinical Stage IVB Gastric Cancer AJCC v8|Metastatic Colon Carcinoma|Metastatic Esophageal Carcinoma|Metastatic Gastric Carcinoma|Metastatic Liver Carcinoma|Metastatic Malignant Digestive System Neoplasm|Metastatic Malignant Small Intestinal Neoplasm|Metastatic Malignant Thoracic Neoplasm|Metastatic Pancreatic Carcinoma|Metastatic Rectal Carcinoma|Pathologic Stage IV Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IV Esophageal Squamous Cell Carcinoma AJCC v8|Pathologic Stage IV Gastric Cancer AJCC v8|Pathologic Stage IVA Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IVA Esophageal Squamous Cell Carcinoma AJCC v8|Pathologic Stage IVB Esophageal Adenocarcinoma AJCC v8|Pathologic Stage IVB Esophageal Squamous Cell Carcinoma AJCC v8|Postneoadjuvant Therapy Stage IV Esophageal Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IV Esophageal Squamous Cell Carcinoma AJCC v8|Postneoadjuvant Therapy Stage IV Gastric Cancer AJCC v8|Postneoadjuvant Therapy Stage IVA Esophageal Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IVA Esophageal Squamous Cell Carcinoma AJCC v8|Postneoadjuvant Therapy Stage IVB Esophageal Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IVB Esophageal Squamous Cell Carcinoma AJCC v8|Stage IV Colon Cancer AJCC v8|Stage IV Hepatocellular Carcinoma AJCC v8|Stage IV Pancreatic Cancer AJCC v8|Stage IV Rectal Cancer AJCC v8|Stage IV Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8|Stage IVA Colon Cancer AJCC v8|Stage IVA Hepatocellular Carcinoma AJCC v8|Stage IVA Rectal Cancer AJCC v8|Stage IVB Colon Cancer AJCC v8|Stage IVB Hepatocellular Carcinoma AJCC v8|Stage IVB Rectal Cancer AJCC v8|Stage IVC Colon Cancer AJCC v8|Stage IVC Rectal Cancer AJCC v8
Interventions: OTHER: Best Practice|PROCEDURE: Patient Monitoring|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: 3D VR and Hands-on Horticultural Activities Effects
Status: COMPLETED
Conditions: Horticultural Therapy|Virtual Reality
Interventions: OTHER: Combination of 3D VR and Hands-on Horticultural Activities
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Multi-pronged Ethanol Ablation and Radiofrequency Ablation of Early-stage Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: multi-pronged ethanol ablation|PROCEDURE: radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Arimidex Multicenter Trial in Growth Hormone (GH) Deficient Boys
Status: COMPLETED
Conditions: Hypopituitarism
Interventions: DRUG: Arimidex (Anastrozole)|DRUG: Placebo|DRUG: Growth Hormone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Evaluation of Ketoflo
Status: COMPLETED
Conditions: Epilepsy Intractable|Glucose Transporter Type 1 Deficiency Syndrome|Ketogenic Dieting
Interventions: DIETARY_SUPPLEMENT: Ketoflo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combined Biological Treatment and Chemotherapy for Patients With Inoperable Cholangiocarcinoma
Status: COMPLETED
Conditions: Cholangiocarcinoma
Interventions: DRUG: Gemcitabine, Oxaliplatin, Capecitabine,|DRUG: Panitumumab, Gemcitabine, Oxaliplatin, Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Levetiracetam in Chronic Neuropathic Pain Following Spinal Cord Injury
Status: COMPLETED
Conditions: Injuries, Spinal Cord|Pain
Interventions: DRUG: Levetiracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effectiveness of Three Teaching Methods in Oral Hygiene in Adolescent Orthodontic Patients
Status: RECRUITING
Conditions: Orthodontic Appliance
Interventions: BEHAVIORAL: Control group|BEHAVIORAL: Group with active participation|BEHAVIORAL: Group with video and quizz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Long-term Follow-up Study for Patients Treated With CLBR001 CAR-T
Status: ENROLLING_BY_INVITATION
Conditions: Relapsed/Refractory B-cell Lymphomas|Diffuse Large B-Cell Lymphoma (DLBCL)|Follicular Lymphoma (FL)|Chronic Lymphocytic Leukemia (CLL)|Marginal Zone Lymphoma (MZL)|Mantle Cell Lymphoma (MCL)|Small Lymphocytic Lymphoma (SLL)|Primary Mediastinal Large B Cell Lymphoma|Transformed Follicular Lymphoma|Waldenstrom Macroglobulinemia|Lymphoplasmacytic Lymphoma|Burkitt Lymphoma
Interventions: COMBINATION_PRODUCT: CLBR001 and SWI019
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety Study of Sublingual Immunotherapy Tablets of House Dust Mite Allergen Extracts in Adolescents
Status: COMPLETED
Conditions: House Dust Mite Allergic Rhinitis
Interventions: BIOLOGICAL: SLIT tablets of HDM allergen extracts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Soticlestat in Adults With Liver Failure Compared to Those With Normal Liver Function
Status: COMPLETED
Conditions: Hepatic Impairment|Healthy Volunteers
Interventions: DRUG: Soticlestat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of the Safety and Tolerability of PCI-32765 in Patients With Recurrent B Cell Lymphoma
Status: COMPLETED
Conditions: B-Cell Lymphoma|B-Cell Leukemia
Interventions: DRUG: PCI-32765
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety Study of Single and Multiple Oral Doses Prodarsan™ in Patients With Cockayne Syndrome
Status: COMPLETED
Conditions: Cockayne Syndrome
Interventions: DRUG: Prodarsan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Immunogenicity and Safety of a Novel Adjuvanted HBV Vaccine in Pre-liver Transplant Patients 18 Years of Age
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: HBV-MPL vaccine 208129|BIOLOGICAL: Engerix™-B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 0.05 Versus 0.1 mg Spinal Morphine for Reducing Morphine Requirement After Vaginal Hysterectomy
Status: UNKNOWN
Conditions: Pain|Vaginal Hysterectomy
Interventions: DRUG: Spinal morphine 0.05 mg|DRUG: Spinal morphine 0.1 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nebulized Epinephrine vs. Salbutamol in Bronchiolitis Among Children
Status: COMPLETED
Conditions: Respiratory Distress Score
Interventions: DRUG: Salbutamol|DRUG: Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nutritional Problems After Lung and Heart Transplantation
Status: UNKNOWN
Conditions: Bone Density|Overweight
Interventions: DRUG: Vitamin K|DRUG: Vitamin K
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Comparing a Soybean Oil-Based With an Olive Oil-Based Lipid Emulsion in ICU Patients Requiring TPN
Status: COMPLETED
Conditions: Parenteral Nutrition
Interventions: DRUG: ClinOleic 20% Intravenous Emulsion|DRUG: Intralipid, 20% Intravenous Emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Controlled Clinical Study of Dupilumab in Patients With Nasal Polyps
Status: COMPLETED
Conditions: Chronic Rhinosinusitis Phenotype With Nasal Polyps (CRSwNP)
Interventions: DRUG: Dupilumab SAR231893 (REGN668)|DRUG: Placebo|DRUG: Mometasone furoate nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Susceptibility Testing In Neisseria Gonorrhoeae (STING) Study, Assessing the Performance of a New Rapid Test for Gonorrhoea Antibiotic Resistance, in a Cohort of 100 Culture Positive Neisseria Gonorrhoeae Infections
Status: NOT_YET_RECRUITING
Conditions: Diagnosis|Gonorrhea|Resistance Bacterial
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Deep Brain Stimulation in Forel's H Field in Tourette's Syndrome
Status: UNKNOWN
Conditions: Tourette Syndrome
Interventions: DEVICE: Deep Brain Stimulation (DBS)|DEVICE: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Guanfacine to Reduce Stress-Induced Cocaine/Alcohol Craving and Relapse
Status: COMPLETED
Conditions: Cocaine Dependent|Alcohol Dependent
Interventions: DRUG: Guanfacine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: HPPH Photodynamic Therapy for Patients With Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: DRUG: HPPH 2.5 mg/m2|DRUG: HPPH 3 mg/m2|DRUG: HPPH 3.5 mg/m2|DRUG: HPPH 4 mg/m2|DRUG: HPPH 5 mg/m2|DRUG: HPPH 6 mg/m2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TACTICS (Targeting Adherence to Cholesterol-lowering Therapy to Improve Control Study)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: BEHAVIORAL: stage-matched intervention|BEHAVIORAL: framing effects intervention|BEHAVIORAL: attention placebo intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Effects of Using Prime-boost HIVIS DNA and MVA-CMDR Vaccine Regimens With or Without Toll-like Receptor 4 Agonist on HIV Reservoirs in Perinatally HIV Infected Children and Youth
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections
Interventions: BIOLOGICAL: HIVIS DNA/MVA-CMDR|BIOLOGICAL: HIVIS DNA + Cervarix and MVA-CMDR|BIOLOGICAL: Cervarix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Niraparib With Standard Combination Radiation Therapy and Androgen Deprivation Therapy in Treating Patients With High Risk Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Adenocarcinoma|Stage IIC Prostate Cancer AJCC v8|Stage III Prostate Cancer AJCC v8|Stage IIIA Prostate Cancer AJCC v8|Stage IIIB Prostate Cancer AJCC v8|Stage IIIC Prostate Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8
Interventions: BIOLOGICAL: Gonadotrophin Releasing Hormone|RADIATION: Intensity-Modulated Radiation Therapy|DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palbociclib and Sorafenib, Decitabine, or Dexamethasone in Treating Patients With Recurrent or Refractory Leukemia
Status: RECRUITING
Conditions: Recurrent Acute Lymphoblastic Leukemia|Recurrent Acute Myeloid Leukemia|Refractory Acute Lymphoblastic Leukemia|Refractory Acute Myeloid Leukemia
Interventions: DRUG: Decitabine|DRUG: Dexamethasone|DRUG: Palbociclib|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on Macitentan, RT and TMZ Concurrent Therapy Followed by Maintenance Macitentan and TMZ in Newly Diagnosed Glioblastoma
Status: TERMINATED
Conditions: Glioblastoma
Interventions: DRUG: Macitentan in combination with RT and TMZ
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Video-capsule Endoscopy in Gastrointestinal Bleeding of Obscure Origin
Status: COMPLETED
Conditions: Gastrointestinal Bleeding
Interventions: DEVICE: Capsule GIVEN IMAGING|PROCEDURE: Push-Enteroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Global Study to Assess the Effects of Osimertinib Following Chemoradiation in Patients With Stage III Unresectable Non-small Cell Lung Cancer (LAURA)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer (Stage III)
Interventions: DRUG: Osimertinib 80mg/40mg|DRUG: Placebo Osimertinib 80mg/40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Glucose Control With Multiple Daily Insulin Injections In Diabetic Patients Hospitalized In A General Medicine Ward
Status: TERMINATED
Conditions: Diabetes Mellitus
Interventions: DRUG: Glargine and insulin aspart or lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of PF-07055480 / Giroctocogene Fitelparvovec Gene Therapy in Moderately Severe to Severe Hemophilia A Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Hemophilia A
Interventions: BIOLOGICAL: PF-07055480 (giroctocogene fitelparovec): Recombinant AAV2/6 Human Factor VIII Gene Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of HIV Remission Upon cART Interruption in Early Treated Individuals Carrying the MHC B35/53Bw4TTC2 Genotype
Status: RECRUITING
Conditions: HIV Infections
Interventions: OTHER: Analytical Treatment Interruption (ATI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Training "Pain Connoisseurs" for Efficient Analgesic Proof-of-Concept Studies
Status: COMPLETED
Conditions: Painful Diabetic Neuropathy (PDN)
Interventions: OTHER: EPT|DRUG: Drug Placebo Administration|OTHER: C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Study of Denosumab in the Treatment of Hypercalcemia of Malignancy in Subjects With Elevated Serum Calcium
Status: COMPLETED
Conditions: Breast Cancer|Hypercalcemia of Malignancy|Colon Cancer|Endocrine Cancer|Head and Neck Cancer|Kidney Cancer|Lung Cancer|Lymphoma|Metastatic Cancer|Multiple Myeloma|Parathyroid Neoplasms|Renal Cancer|Thyroid Cancer|Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma|Non-Small Cell Lung Cancer
Interventions: DRUG: denosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allograft With Enamel Matrix Derivative Versus Allograft Alone in the Treatment of Intrabony Defects .
Status: COMPLETED
Conditions: Intrabony Periodontal Defect
Interventions: PROCEDURE: Freeze-dried bone allograft combined with Enamel Matrix derivative|PROCEDURE: Freeze-dried bone allograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Trial of Deep Brain Stimulation for Spasmodic Dysphonia
Status: NOT_YET_RECRUITING
Conditions: Spasmodic Dysphonia
Interventions: DEVICE: DBS ON|DEVICE: DBS OFF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab and Lurbinectedin for the Treatment of Relapsed or Refractory Small Cell Lung Cancer
Status: RECRUITING
Conditions: Platinum-Resistant Lung Small Cell Carcinoma|Platinum-Sensitive Lung Small Cell Carcinoma|Recurrent Extensive Stage Lung Small Cell Carcinoma|Refractory Extensive Stage Lung Small Cell Carcinoma
Interventions: BIOLOGICAL: Durvalumab|DRUG: Lurbinectedin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Combined Blood Clot and Platelet Rich Fibrin Scaffolds in Regeneration of Necrotic Immature Permanent Teeth
Status: COMPLETED
Conditions: Pulp Necroses
Interventions: BIOLOGICAL: Blood clot scaffold|BIOLOGICAL: Blood clot scaffold combined with PRF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Levosimendan on Cellular Metabolic Alterations in Patients With Septic Shock
Status: UNKNOWN
Conditions: Septic Shock
Interventions: DEVICE: Microdialysis Probe (Muscle microdialysis)|DRUG: Dobutamine|DRUG: Levosimendan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Differences in Predicted Therapeutic Outcome of Oral Appliance Determined by RCMP in Quebec Versus Shenyang Patients With OSA.
Status: UNKNOWN
Conditions: Remotely Controlled Mandibular Positioner
Interventions: DEVICE: Remotely Controlled Mandibular Positioner (RCMP)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Of Duloxetine Hydrochloride Hard Gelatinous Capsule Compared To Cymbalta Under Fed Conditions
Status: WITHDRAWN
Conditions: Healthy
Interventions: DRUG: Cymbalta capsule|DRUG: Duloxetine hydrochloride capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Fixed Dose Efficacy and Safety Study of Asenapine for the Treatment of Schizophrenia in Adolescents (P05896)
Status: COMPLETED
Conditions: Schizophrenia, Paranoid|Schizophrenia, Disorganized|Schizophrenia, Undifferentiated
Interventions: DRUG: asenapine 2.5 mg|DRUG: asenapine 5.0 mg|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Effects of Atorvastatin Versus Rosuvastatin on Cardiac Function in Heart Failure Patients
Status: UNKNOWN
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: Atorvastatin Oral Tablet|DRUG: Rosuvastatin Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Investigation of Low Molecular Weight (LMW) Heparin/Edoxaban Tosylate (DU176b) Versus (LMW) Heparin/Warfarin in the Treatment of Symptomatic Deep-Vein Blood Clots and/or Lung Blood Clots. (The Edoxaban Hokusai-VTE Study).
Status: COMPLETED
Conditions: Venous Thromboembolism|Deep Vein Thrombosis (DVT)|Pulmonary Embolism (PE)|Thromboembolism|Venous Thrombosis
Interventions: DRUG: edoxaban tosylate(DU-176b)|DRUG: low molecular weight heparin/unfractionated heparin|DRUG: warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AcQBlate Force Sensing Ablation System US IDE Study for Atrial Fibrillation
Status: WITHDRAWN
Conditions: Paroxysmal Atrial Fibrillation|Persistent Atrial Fibrillation
Interventions: DEVICE: AcQBlate® Force Sensing Ablation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective CoHoRt Of Non-infectious Intermediate, pOsterior or panuveitiS
Status: NOT_YET_RECRUITING
Conditions: Non-infectious Uveitis
Interventions: DIAGNOSTIC_TEST: care strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neurophysiological Validation of the Clinical Criteria of Sensitization in Chronic Pelvic and Perineal Pain Population
Status: TERMINATED
Conditions: Chronic Pelvic Pain|Chronic Perineal Pain
Interventions: OTHER: Sensory testing of lower urinary tract.|OTHER: Sensory testing of lower rectal tract|OTHER: Sensory testing of vulva muscles|OTHER: Sensory testing of pelvic muscles
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Comparing Continuous Subcutaneous Insulin Infusion With Multiple Daily Injections With Insulin Lispro and Glargine
Status: COMPLETED
Conditions: Diabetes Mellitus Type 1
Interventions: DEVICE: Insulin pumps
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study on the Safety, Effectiveness and Immune Response of Meningococcal Combined ABCWY Vaccine in Healthy Adolescents and Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Infections, Meningococcal
Interventions: COMBINATION_PRODUCT: MenABCWY-2Gen low dose vaccine|COMBINATION_PRODUCT: MenABCWY-2Gen high dose vaccine|COMBINATION_PRODUCT: Placebo|COMBINATION_PRODUCT: MenB vaccine|BIOLOGICAL: MenACWY vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Substance Use Disorders
Interventions: DRUG: Brexpiprazole|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Clinical Trial of ACTHar Gel 14 Days Subcutaneous (SQ)Versus ACTHar Gel Five Days SQ for the Treatment of MS Exacerbations
Status: COMPLETED
Conditions: Multiple Sclerosis (MS)
Interventions: DRUG: H.P. Acthar Gel (repository corticotropin injection)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Confirmatory Clinical Evaluation of Novilase® Laser Therapy for Focal Destruction of Malignant Breast Tumors
Status: RECRUITING
Conditions: Malignant Neoplasm of Breast
Interventions: DEVICE: Novilase Laser ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Pharmacokinetics of AGS-8M4 Given in Combination With Chemotherapy in Women With Ovarian Cancer
Status: TERMINATED
Conditions: Carcinoma|Ovarian Cancer|Ovarian Diseases|Ovarian Neoplasms
Interventions: BIOLOGICAL: AGS-8M4|DRUG: Pegylated liposomal doxorubicin (PLD)|DRUG: gemcitabine|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT