pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: An Evaluation of Sarilumab Plus Methotrexate Compared to Etanercept Plus Methotrexate in RA Patients Not Responding to Adalimumab Plus Methotrexate
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Sarilumab|DRUG: Etanercept|DRUG: Methotrexate|DRUG: Placebo (for sarilumab)|DRUG: Placebo (for etanercept)|DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Tunneled Catheter Thrombosis in Hemodialysis Patients: Prospective Study From Qatar
Status: COMPLETED
Conditions: Hemodialysis, Tunneled Catheter, Qatar
Interventions: DRUG: TauroLock U 25000|DRUG: (TauroLock Hep500)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Versus Fentanyl as an Adjuvant to Bupivacaine in Saddle Block
Status: COMPLETED
Conditions: Regional Anesthesia Morbidity
Interventions: DRUG: FENT group|DRUG: DEX group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Gait and Functional Outcomes Study Following Total Knee Arthroplasty With Medial-pivot or Posterior-stabilized Implants
Status: COMPLETED
Conditions: Joint Disease
Interventions: DEVICE: Group 1 (Medial-Pivot)|DEVICE: Group 2 (Posterior-Stabilized)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Surgery for Primary Congenital Glaucoma in Neonates
Status: UNKNOWN
Conditions: Primary Congenital Glaucoma
Interventions: PROCEDURE: viscotrabeculotomy (VT)|PROCEDURE: visco-circumferential-suture-trabeculotomy (VCST) .|PROCEDURE: combined VT-Trabeculectomy with MMC (VT-Trab).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess EN3835 in the Treatment of Plantar Fibromatosis (Also Known as Ledderhose Disease)
Status: RECRUITING
Conditions: Plantar Fibromatosis|Ledderhose Disease
Interventions: BIOLOGICAL: EN3835|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study: Focused Ultrasound Thalamotomy for the Prevention of Secondary Generalization in Focal Onset Epilepsy
Status: RECRUITING
Conditions: Partial Seizures With Secondary Generalization
Interventions: DEVICE: High Intensity Focused Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Vitrase for Clearance of Severe Vitreous Hemorrhage
Status: COMPLETED
Conditions: Vitreous Hemorrhage|Diabetic Retinopathy
Interventions: DRUG: Placebo|DRUG: Vitrase|DRUG: Vitrase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Remediation in Forensic Mental Health Care
Status: RECRUITING
Conditions: Psychotic Disorders|ADHD|TBI (Traumatic Brain Injury)|Aggression|Substance Use Disorders|Violence|Cognitive Dysfunction|Anxiety|Depression|Schizophrenia|Offenders|Antisocial
Interventions: BEHAVIORAL: Cognitive Remediation|BEHAVIORAL: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Early Morphine Administration on the Development of Acute Opioid Tolerance During Pediatric Scoliosis Surgery
Status: COMPLETED
Conditions: Scoliosis
Interventions: DRUG: Morphine|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin, Gemcitabine, Erlotinib, and Radiation Therapy in Treating Patients With Unresectable and/or Metastatic Pancreatic Cancer or Biliary Tract Cancer
Status: COMPLETED
Conditions: Extrahepatic Bile Duct Cancer|Gallbladder Cancer|Pancreatic Cancer
Interventions: DRUG: erlotinib hydrochloride|DRUG: gemcitabine hydrochloride|DRUG: oxaliplatin|RADIATION: radiation therapy|DRUG: gemcitabine hydrochloride|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Trial Evaluating the Safety and Efficacy of Autologous Volar Fibroblast Injection Into the Terminal Limb of Amputees.
Status: RECRUITING
Conditions: Amputation
Interventions: COMBINATION_PRODUCT: Autologous Volar Fibroblast Injection into the Terminal Limb of Amputees
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Voreloxin (Vosaroxin) in Older Patients With Untreated Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia|Acute Disease|Acute Myeloid Leukemia|Nonlymphocytic Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: vosaroxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Complex Anal Fistula With Draining Seton With or Without Rerouting of Track
Status: COMPLETED
Conditions: Anal Fistula
Interventions: PROCEDURE: Draining seton|PROCEDURE: Rerouting of track
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of the Immune Modulator Dimethyl Fumarate With Intraarterial Treatment in Acute Ischemic Stroke
Status: WITHDRAWN
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Dimethyl Fumarate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 68Ga-NOTA-PRGD2 PET/CT in Patients With Lung Injury and Pulmonary Fibrosis
Status: UNKNOWN
Conditions: Pulmonary Fibrosis, Unspecified
Interventions: DRUG: 68Ga-NOTA-PRGD2|DEVICE: PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Experimental Manipulation of Sleep and Circadian Rhythms and the Role Played on Reward Function in Teens
Status: RECRUITING
Conditions: Delayed Sleep Phase Syndrome
Interventions: OTHER: Increase morning bright light|OTHER: Decrease evening blue light|BEHAVIORAL: Sleep Scheduling|BEHAVIORAL: Monitor sleep, mood, and substance use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Selumetinib in Patients With Previously Treated or Untreated Advanced/Metastatic NSCLC
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Selumetinib|DRUG: Pemetrexed|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Active-control Randomised Trial Comparing 4-factor Prothrombin Complex Concentrate With Frozen Plasma in Cardiac Surgery
Status: COMPLETED
Conditions: Bleeding Cardiac Surgery Patients
Interventions: DRUG: Octaplex|DRUG: Frozen Plasma Product, Human
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: mHealth ElectroNic COnsultation REcording (mENCORE) in Advanced Prostate Cancer
Status: COMPLETED
Conditions: Metastatic Prostate Cancer
Interventions: OTHER: Medcorder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Photobiomodulation on Postoperative Pain
Status: UNKNOWN
Conditions: Knee Osteoarthritis|Metabolic Disease
Interventions: DEVICE: Photobiomodulation + patiente controled anaethesia (PCA)|DEVICE: Placebo + patiente controled anaethesia (PCA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing PF-05089771 TS Tablet to PF-05089771 TS Oral Dispersion In The Fasted State And To PF-05089771 TS Tablet In The Fasted And Fed State
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: PF-05089771|DRUG: PF-05089771|DRUG: PF-05089771
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anlotinib In Combination With Durvalumab As Sequential Therapy of Thoracic Radiotherapy After Induction Chemotherapy For Extensive-Stage Small Cell Lung Cancer:A Single Arm Study
Status: UNKNOWN
Conditions: Anlotinib|Durvalumab|Small Cell Lung Cancer
Interventions: DRUG: Anlotinib In Combination With Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Fenestrated Cup Forceps Versus Fenestrated Alligator Forceps for Performing Transbronchial Lung Biopsy in Patients With Sarcoidosis
Status: COMPLETED
Conditions: Sarcoidosis
Interventions: DEVICE: Cup forceps|DEVICE: Alligator forceps
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Immunogenicity of a Cell Derived Subunit Trivalent Nonadjuvanted Influenza Study Vaccine in Adults Aged 18 Years and Above
Status: COMPLETED
Conditions: Human Influenza
Interventions: BIOLOGICAL: TIVc
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Adjuvant Gemcitabine Versus 5-FU/Leucovorin Based on hENT1 Immunostaining
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: hENT1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating INIPARIB in Combination With Chemotherapy to Treat Triple Negative Breast Cancer Brain Metastasis
Status: COMPLETED
Conditions: Estrogen Receptor Negative (ER-Negative) Breast Cancer|Progesterone Receptor Negative (PR-Negative) Breast Cancer|Human Epidermal Growth Factor Receptor 2 Negative (HER2-Negative) Breast Cancer|Brain Metastases
Interventions: DRUG: INIPARIB + irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Universal CAR-T Cells (BRL-301) in Relapse or Refractory Autoimmune Diseases
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus (SLE)|Sjogren's Syndrome|Systemic Sclerosis|Inflammatory Myopathy|ANCA Associated Systemic Vasculitis|Antiphospholipid Syndrome
Interventions: BIOLOGICAL: BRL-301
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selenium for Prevention of Adenomatous Colorectal Polyps
Status: TERMINATED
Conditions: Colorectal Cancer|Adenomatous Colorectal Polyps|Precancerous Condition
Interventions: DRUG: Selenium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Double Blind Placebo Controlled Dose Ranging Study of the Efficacy and Safety of SSR149744c 100 or 300 mg for the Prevention of ventrICular ARrhythmia-triggered Icd interventiOnS
Status: COMPLETED
Conditions: Arrhythmia|Tachycardia, Ventricular|Ventricular Fibrillation
Interventions: DRUG: SSR149744C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SELUTION4BTK Trial
Status: RECRUITING
Conditions: Peripheral Arterial Disease|Chronic Limb-Threatening Ischemia Nos of Native Arteries of Extremities
Interventions: DEVICE: SELUTION SLR™ DEB 014|DEVICE: Plain (Uncoated) Balloon Angioplasty (PTA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study Of Sunitinib Compared To Placebo For Patients With Advanced Pancreatic Islet Cell Tumors
Status: TERMINATED
Conditions: Carcinoma, Islet Cell|Carcinoma, Pancreas
Interventions: DRUG: sunitinib malate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Geographic Atrophy Treatment Evaluation
Status: TERMINATED
Conditions: Geographic Atrophy|Age-Related Macular Degeneration
Interventions: DRUG: AL-8309B Ophthalmic Solution|DRUG: AL-8309B Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Post-marketing, Blinded Study to Investigate How Effective Fidaxomicin is Compared to Vancomycin in the Sustained Cure of Clostridium Difficile Infection in Adults That Are Receiving Therapy to Suppress the Immune System
Status: TERMINATED
Conditions: Clostridium Difficile
Interventions: DRUG: Fidaxomicin|DRUG: Vancomycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Condensed and Distributed Robotic Therapy in Spastic Stroke Post Botulinum Toxin Injection
Status: COMPLETED
Conditions: Stroke|Hemiplegia, Spastic
Interventions: DEVICE: condensed RT group|DEVICE: distributed RT group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Persistent Post-Surgical Pain and Dysfunction
Status: RECRUITING
Conditions: Pain|Function|Anxiety|Depression|Arthroplasty, Replacement, Knee|Veterans
Interventions: BEHAVIORAL: Acceptance and Committment Therapy (ACT)|OTHER: Attention Control (AC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MARIS Study; Mediterranean Approach to Reduce Insulin-Resistance Study
Status: COMPLETED
Conditions: Insulin Resistance|Metabolic Syndrome X|Dyslipidemia|Hypertension|Overweight
Interventions: BEHAVIORAL: Isocaloric diet high in MUFA or Mediterranean diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: Effects of STN DBS on Cognition and Brain Networks in PD Patients Analyzed Based on EEG and fNIRS
Status: RECRUITING
Conditions: Parkinson's Disease|Executive Function|Electroencephalogram|Functional Near - Infrared Spectroscopy
Interventions: PROCEDURE: Deep Brain Stimulation|PROCEDURE: non-Deep Brain Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protecting Brains and Saving Futures - the PBSF Protocol
Status: UNKNOWN
Conditions: Brain Injuries|Congenital Heart Disease|Newborn Morbidity|Intraventricular Hemorrhage|CNS Infection|Neonatal Seizure|Nosocomial Infection|Hypoxic-Ischemic Encephalopathy|Extreme Prematurity|Brain Malformation|Congenital Infection|Neonatal Stroke|Hemodynamic Instability|Extracorporeal Membrane Oxygenation Complication|Inborn Errors of Metabolism|Respiratory Complication|Neonatal Death
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Azathioprine Versus Corticosteroids in Parthenium Dermatitis
Status: COMPLETED
Conditions: Parthenium Dermatitis
Interventions: DRUG: azathioprine and corticosteroids for Parthenium dermatitis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Stage III or Stage IV Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: mitoxantrone hydrochloride|DRUG: thiotepa|DRUG: topotecan hydrochloride|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Assessement of Viral Shedding Duration After a Respiratory Tract Infection in Oncology and Hematology Patients
Status: COMPLETED
Conditions: Respiratory Tract Viral Infection
Interventions: DIAGNOSTIC_TEST: nasal swabs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity of Oral Cholera Vaccine in Kolkata
Status: COMPLETED
Conditions: Cholera
Interventions: BIOLOGICAL: killed whole cell oral cholera vaccine|BIOLOGICAL: Heat Killed E. coli
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cross-over Comparison of the V60 System to Other Bi-Level Noninvasive Ventilators
Status: COMPLETED
Conditions: Respiratory Insufficiency|Respiratory Failure
Interventions: DEVICE: noninvasive ventilator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Preliminary Investigation of the Efficacy of Aromatherapy in Reducing Discomfort in Youth With Chronic Headache
Status: COMPLETED
Conditions: Chronic Headache|Migraine Headache|Headache
Interventions: OTHER: aromatherapy|OTHER: foot bath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability Study of Subcutaneous Injection Versus Intravenous Infusion of Pembrolizumab (MK-3475) in Participants With Advanced Melanoma (MK-3475-555/KEYNOTE-555)
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: Pembrolizumab Dose C|BIOLOGICAL: Pembrolizumab Dose A|BIOLOGICAL: Pembrolizumab Dose B|BIOLOGICAL: Pembrolizumab Dose D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Dose Finding Study of Belinostat for Treatment of Patients With Peripheral T-cell Lymphoma (PTCL)
Status: COMPLETED
Conditions: Peripheral T-cell Lymphoma
Interventions: DRUG: Belinostat|DRUG: CHOP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Ability to Detect Bowel Gas During Laparoscopic Right Colectomy With Intracorporeal Anastomosis
Status: RECRUITING
Conditions: Crohn's Disease of Large Intestine|Malignant Neoplasm of Colon
Interventions: DEVICE: Obtaining bowel gas samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Endostar Combined With TP Regimen for Esophageal Cancer
Status: UNKNOWN
Conditions: Patients With Esophageal Cancer(Ⅱ-Ⅲ)
Interventions: DRUG: endostar+chemoradiotherapy|OTHER: chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: hCG-activated PBMC-therapy in RIF Patients
Status: COMPLETED
Conditions: Recurrent Implantation Failure
Interventions: OTHER: Peripheral Blood Monouclear Cell|OTHER: Phosphate Baffer Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarker Study in Patients With Trigeminal Neuralgia
Status: RECRUITING
Conditions: Trigeminal Neuralgia
Interventions: PROCEDURE: trigminal nerve block with RFT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Investigation Into the Effects of Blueberry Anthocyanin on Cognitive Functioning and Mood in Adolescents.
Status: COMPLETED
Conditions: Depression
Interventions: DIETARY_SUPPLEMENT: Wild Blueberry Powder-13g|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Three Batches Consistency and Immunity Duration of the Post-marketing Inactivated Enterovirus Type 71 (EV71) Vaccine in Children Aged 6-71 Months
Status: UNKNOWN
Conditions: Hand Foot and Mouth Disease
Interventions: BIOLOGICAL: the first batch vaccine|BIOLOGICAL: the second batch vaccine|BIOLOGICAL: the third batch vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Kunamin in SARS-CoV-2 RT-PCR Positive Covid-19 Patients
Status: COMPLETED
Conditions: COVID-19 Respiratory Infection|FLU|Cold; Influenza|Bacterial Pneumonia|COVID-19 Pneumonia
Interventions: DIETARY_SUPPLEMENT: Kunamin®|DRUG: Favipiravir|DRUG: Enoxaparin|DRUG: Lansoprazole|DRUG: Paracetamol|DRUG: Ceftriaxone/ Clarithromycin|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regorafenib in GIST With Secondary C-KIT Exon 17 Mutation
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumour (GIST)
Interventions: DRUG: regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Essentiality of INH in TB Therapy
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: Rifampicin|DRUG: Isoniazid|DRUG: Pyrazinamide|DRUG: Ethambutol|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sub-Paraspinal Block in Nuss Patients. A Pilot Project
Status: COMPLETED
Conditions: Pectus Excavatum|Pain, Postoperative
Interventions: PROCEDURE: Ultrasound-guided Sub-Paraspinal Block|PROCEDURE: PCA only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 2 Study of CIN-102 in Adults With Idiopathic and Diabetic Gastroparesis
Status: COMPLETED
Conditions: Gastroparesis
Interventions: DRUG: CIN-102 Dose 1|DRUG: CIN-102 Dose 2|DRUG: CIN-102 Dose 3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Effectiveness of the 217z Laser With Zyoptix for Lasik
Status: WITHDRAWN
Conditions: Myopia|Astigmatism
Interventions: DEVICE: 217z Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate QLS-101 Compared to Timolol Maleate Eye Drops in Subjects With High Eye Pressure (Glaucoma or Ocular Hypertension).
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: QLS-101|DRUG: Timolol Maleate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Diaphragmatic Thickening to Monitor Its Dysfunction in Patients With Sepsis
Status: COMPLETED
Conditions: Sepsis|Disease of Diaphragm|Defect of Diaphragm|Intensive Care Neuropathy
Interventions: DEVICE: Diaphragmatic ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver Disease
Status: RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease|Non-alcoholic Steatohepatitis|Obesity
Interventions: DEVICE: Endoscopic ultrasound shear wave elastography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ninvasive Cardiac Output Measurements During Cesarean Delivery Under Spinal Anesthesia.
Status: COMPLETED
Conditions: Hypotension During Cesarean Delivery|Spinal Anesthesia
Interventions: DEVICE: Cardiac output monitor data
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetic Characteristics Evaluation on GST-HG171 Tablets
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: GST-HG171|DRUG: placebo of GST-HG171
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of PurTox® Botulinum Toxin Type A to Treat Frown Lines Between the Eyebrows
Status: COMPLETED
Conditions: Glabellar Rhytides
Interventions: DRUG: Preservative-free Saline|DRUG: Mentor Purified Toxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial to Evaluate the Efficacy of Acupuncture Versus Aromatherapy as Treatments to Lessen Nausea, Vomiting and Anxiety Associated With Adriamycin and Cytoxan
Status: UNKNOWN
Conditions: Nausea|Vomiting|Anxiety
Interventions: OTHER: Acupuncture|OTHER: Aromatherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Non-invasive Measurement of Electrophysiological "HV" Interval Using a High-density and High-fidelity Signal Averaging ECG Device
Status: COMPLETED
Conditions: Cardiac Electrophysiology|Electrocardiogram
Interventions: PROCEDURE: Electrophysiological exploration|DEVICE: ECG Biosemi
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Tolerance (Main Objective) and Performance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots (Solar and Senile Lentigines, Post-inflammatory Hyperpigmentation) on the Face
Status: NOT_YET_RECRUITING
Conditions: Lentigo|Solar Lentigo|Post Inflammatory Hyperpigmentation
Interventions: DEVICE: CRYONOVE (EC14_4osc)|DEVICE: CRYONOVE (EC+05_1osc)|DEVICE: CRYONOVE (EC+05_2osc)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Improving Performance of Combat Soldiers by Utilizing Attentional Training Based on Eye Tracking
Status: TERMINATED
Conditions: Military Combat Performance
Interventions: BEHAVIORAL: Gaze-Contingent Feedback Training|BEHAVIORAL: Attention Bias Modification|BEHAVIORAL: Non-Contingent Feedback Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Phase 1 ID93 + GLA-SE Vaccine Trial in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Pulmonary Tuberculosis
Interventions: BIOLOGICAL: ID93 + GLA-SE|BIOLOGICAL: ID93 alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fecal Microbiota Transplantation as a Therapeutic Strategy in the Progression of Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease Due to Hypertension|Chronic Kidney Disease Due to Type 2 Diabetes Mellitus
Interventions: BIOLOGICAL: Faecal microbiota transplant|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Accelerated v's Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours
Status: UNKNOWN
Conditions: Germ Cell Tumor
Interventions: DRUG: Bleomycin (active name: Bleomycin Sulfate)|DRUG: Etoposide|DRUG: Cisplatin|DRUG: Pegylated G-CSF (Pegfilgrastim)|DRUG: Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tongjiang Series Prescription Combined With PPIs Descending Ladder Withdrawal in Treating Nonerosive Reflux Disease
Status: UNKNOWN
Conditions: Nonerosive Reflux Disease
Interventions: DRUG: Tongjiang series prescription(Tongjiang granules, Jianpi Qinghua granules and Wenpi Qingwei granules)|DRUG: Acid inhibitors|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Genetically Engineered Cells (MUC1-Activated T-Cells) for the Treatment of MUC1 Positive Recurrent or Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: BIOLOGICAL: Autologous MUC1-activated T-cells|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of Oral Ixabepilone in Subjects With Advanced Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Ixabepilone, 5 mg/d|DRUG: Ixabepilone, 10 mg/d|DRUG: Ixabepilone, 15 mg/d|DRUG: Ixabepilone, 20 mg/d|DRUG: Ixabepilone, 25 mg/d|DRUG: Ixabepilone, 30 mg/d|DRUG: Ixabepilone, 25 mg, with famotidine|DRUG: Ixabepilone, 25 mg, with food
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantitative MRI for Patients With Sickle Cell Disease Undergoing Hematopoietic Cell Transplant
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DIAGNOSTIC_TEST: serial functional magnetic resonance imaging (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioavailability and Pharmacokinetics Study of FDL169 in Healthy Subjects and Subjects With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: FDL169
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Eccentric Exercise for Chronic Mid-portion Achilles Tendinopathy
Status: UNKNOWN
Conditions: Achilles Tendon|Tendinopathy
Interventions: PROCEDURE: Standard eccentric exercise|PROCEDURE: Eccentric exercise-Experimental group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bangladesh MSNP: Agricultural/Livelihood Mixed Methods Study
Status: COMPLETED
Conditions: Stunting|Undernutrition
Interventions: OTHER: HFP Intervention: Delivered by Community Farmers|OTHER: HFP Intervention: Delivered by agricultural Retailers|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Post Stroke Preventive Trial (PREVENT). A RCT Nested in a Cohort Study
Status: UNKNOWN
Conditions: Cerebrovascular Accident|Transient Ischemic Attack|Myocardial Infarction
Interventions: BEHAVIORAL: Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immune Thrombocytopenia Management in Adults
Status: RECRUITING
Conditions: Immune Thrombocytopenia Purpura
Interventions: DRUG: Dexamethasone|DRUG: Prednisolone and Azathioprine|DRUG: Rituximab|DRUG: Eltrombopag|DRUG: Romiplostim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Phosphate Binders on Markers of Vascular Health in Chronic Kidney Disease Stages 3 and 4
Status: TERMINATED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Sevelamer carbonate|DRUG: Calcium acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Motivational Instant Messaging and E-diabetes Prevention Programme for High Risk of Type 2 Diabetes
Status: COMPLETED
Conditions: Pre-diabetes
Interventions: DEVICE: Wearable technology|BEHAVIORAL: Diabetes Prevention Programme educational material|BEHAVIORAL: Motivational messaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Comparing Two Methods for the Treatment of Large Chondral and Osteochondral Defects of the Knee
Status: NOT_YET_RECRUITING
Conditions: Articular Cartilage Defect|Chondral Defect|Osteochondritis
Interventions: PROCEDURE: MACT|PROCEDURE: AMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 5 mg Glipizide/500 mg Metformin Hydrochloride Tablets, Fasting
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 5 mg/500 mg Glipizide Metformin Hydrochloride Tablets|DRUG: 5 mg/500 mg METAGLIP™ Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Apremilast in Patients With Moderate to Severe Palmoplantar Pustulosis (PPP) (APLANTUS)
Status: COMPLETED
Conditions: Palmoplantar Pustulosis
Interventions: DRUG: Apremilast
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eze/Simva Switch Study in Diabetics (0653A-807)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: MK0653A, ezetimibe (+) simvastatin / Duration of Treatment: 6 Weeks|DRUG: Comparator: atorvastatin / Duration of Treatment: 6 Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Multiple Doses of Modafinil on the Pharmacokinetics of Single Dose Lorlatinib in Healthy Participants
Status: COMPLETED
Conditions: Adult|Drug Interactions|Healthy Volunteers|Humans
Interventions: DRUG: Lorlatinib 50 mg|DRUG: Lorlatinib 75 mg|DRUG: Lorlatinib 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ANGiographic Evaluation of Left Main Coronary Artery INtErvention
Status: RECRUITING
Conditions: Coronary Occlusion|Left Main Coronary Artery Disease|Coronary Artery Stenosis|Coronary Disease|Coronary Artery Disease
Interventions: OTHER: Angiography and Clinical Follow up|OTHER: Clinical Follow up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrahepatic HCV RNA and Telaprevir Kinetics in Hepatitis C Virus (HCV)
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Telaprevir|DRUG: Peginterferon alfa-2a|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ULTrasound Accelerated ThrombolysIs of PulMonAry Embolism
Status: COMPLETED
Conditions: Submassive Pulmonary Embolism
Interventions: DEVICE: EkoSonic Endovascular System|DRUG: Unfractionated heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selective Thromboembolism Prophylaxis After Arthroplasty
Status: COMPLETED
Conditions: Venous Thrombosis, Deep|Arthroplasty Complications
Interventions: DRUG: selective anticoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics of Efavirenz in HIV-1 Infected Subjects With Hepatic Impairment
Status: COMPLETED
Conditions: HIV Infections|Hepatic Impairment
Interventions: DRUG: efavirenz containing antiretroviral regimen|DRUG: efavirenz containing antiretroviral regimen|DRUG: efavirenz containing antiretroviral regimen|DRUG: efavirenz containing antiretroviral regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Daily Disposable Silicone Hydrogel Multifocal Toric Contact Lenses
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: JJVC Investigational Multifocal Toric Contact Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CHOP-Rituximab Augmented With GM-CSF in Patients With Previously Untreated Diffuse Large B Cell Non-Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Lymphoma, Non-Hodgkin|Lymphoma, B-Cell|Lymphoma, Diffuse
Interventions: DRUG: GM-CSF|DRUG: CHOP|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ischemic Conditioning Improves Walking Function Post Stroke
Status: RECRUITING
Conditions: Stroke|Stroke, Ischemic|Stroke Hemorrhagic|Stroke, Cardiovascular
Interventions: PROCEDURE: Ischemic Conditioning|PROCEDURE: Ischemic Conditioning Sham|PROCEDURE: Treadmill Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomimetic Hydroxyapatite in Pediatric Patients With Asthma and/or Allergic Rhinitis
Status: COMPLETED
Conditions: Dental Caries|Periodontal Diseases
Interventions: OTHER: Biorepair Total Protection Plus + desensitizing enamel-repair shock treatment|OTHER: Sensodyne Repair & Protect
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Iron Treatment of Sleep Disorders in Children With Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Insomnia
Interventions: DRUG: Ferrous sulfate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Comparing Rates of Dementia and Alzheimer's Disease in Participants Initiating Methotrexate Versus Those Initiating Anti-tumor Necrosis Factor (TNF)-Alpha Therapy
Status: COMPLETED
Conditions: Dementia|Alzheimer Disease
Interventions: DRUG: Methotrexate|DRUG: Anti-TNF
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Ability of Electronic Patient Symptom Reporting to Reduce Symptom Burden During Hospitalization for Chemotherapy
Status: COMPLETED
Conditions: Stem Cell Transplantation, Hematopoietic
Interventions: OTHER: Electronic symptom survey|OTHER: Blinded Electronic Symptom Survey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety of H1N1 Influenza Vaccination in Pregnant Women
Status: COMPLETED
Conditions: Virus Diseases|Respiratory Tract Infections|Influenza|Orthomyxoviridae Infections
Interventions: BIOLOGICAL: split-virion, non-adjuvanted H1N1 vaccine of 15 μg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Anlotinib in Patients With Small Cell Lung Cancer (ALTER1202)
Status: COMPLETED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Anlotinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Non- Inferiority Comparative Study Between Seretide® and Salmeterol/Fluticasone Eurofarma in Patients With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Salmeterol/Fluticasone|DRUG: Seretide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Written Behavioural Persuasion Technique Intervention for Hypertension Management
Status: RECRUITING
Conditions: Hypertension|Behavior and Behavior Mechanisms
Interventions: BEHAVIORAL: Written persuasive leaflet|BEHAVIORAL: Standard referral leaflet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Safe Swaddling on Stress and Comfort in Newborns
Status: COMPLETED
Conditions: Stress|Comfort
Interventions: OTHER: Swaddling after bath group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Advanced First-line Treatment of Short-term Postoperative Progression of Head and Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Camrelizumab|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Lobaplatin|DRUG: Nedaplatin|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of a Vaccine Against Influenza (2010-2011 Northern Hemisphere Season, Intradermal Route)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza virus vaccine (split virion, inactivated)|BIOLOGICAL: Influenza virus vaccine (split virion, inactivated)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit.
Status: RECRUITING
Conditions: Fluid Overload
Interventions: DRUG: Furosemide|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Bi-Ligand-Drug Conjugate CBP-1019 in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Cancer, Breast|Cancer, Lung|Cancer of Pancreas|Cancer of Esophagus|Cancer Colorectal
Interventions: DRUG: CBP-1019
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: This Study is to Evaluate the Safety and Efficacy of Avanafil in the Treatment of Erectile Dysfunction.
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Avanafil 100 or 200mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Arterial Stiffness in Type 2 Diabetic Patients With Severe Periodontitis
Status: COMPLETED
Conditions: Coronary Heart Disease|Diabetes Mellitus, Type 2|Periodontitis|Arterial Stiffness
Interventions: DIAGNOSTIC_TEST: clinical periodontal measurements|DIAGNOSTIC_TEST: CAVI measurements
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Brexpiprazole as Adjunctive Treatment in Elderly Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Treatment
Status: TERMINATED
Conditions: Major Depressive Disorder
Interventions: DRUG: Placebo|DRUG: Brexpiprazole 1 mg|DRUG: Brexpiprazole 3 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Therapy of Methadone and Dextromethrophan
Status: UNKNOWN
Conditions: Opioid Abuse
Interventions: DRUG: Dextromethorphan|DRUG: Dextromethorphan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Lebrikizumab (LY3650150) on Vaccine Response in Adults With Atopic Dermatitis (ADopt-VA)
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Lebrikizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Testing Trastuzumab and Pertuzumab in Patients With Higher Than Normal Copies of the HER2 Gene Found in Their Tumors (MATCH - Subprotocol J)
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Solid Neoplasm
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Echocardiography|BIOLOGICAL: Pertuzumab|PROCEDURE: Radiologic Examination|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CO2 Modulation in Endovascular Thrombectomy for Acute Ischemic Stroke
Status: RECRUITING
Conditions: Ischemic Stroke, Acute|Thrombectomy|Anesthesia, General|Cerebrovascular Circulation|Carbon Dioxide
Interventions: BIOLOGICAL: HYPERCAPNIA|BIOLOGICAL: NORMOCAPNIA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT