pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Relationship Between Chiropractic Care and Autonomic Nervous System Regulation
Status: COMPLETED
Conditions: Chiropractic Maintenance Care and Heart Rate Variability
Interventions: OTHER: Chiropractic Maintenance Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation for the Treatment of Auditory Hallucinations in Schizophrenia
Status: TERMINATED
Conditions: Schizophrenia
Interventions: PROCEDURE: rTMS with fMRI-based targeting|PROCEDURE: rTMS with landmark-based targeting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Verbal Communication in Structured Interactions: Theoretical and Clinical Implications
Status: NOT_YET_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: BEHAVIORAL: Structured Communicative Interaction|BEHAVIORAL: Clear Speech|BEHAVIORAL: Unstructured communicative interaction|BEHAVIORAL: Clear Speech Structured Communicative Interaction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Fluvastatin on Biomarkers in Women Who Are Undergoing Surgery for Ductal Carcinoma In Situ or Stage I Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: fluvastatin sodium|PROCEDURE: Breast Cancer Surgery Only - Arm III
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Investigating Tablet Formulations of Lu AF11167 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lu AF11167|DRUG: [14C]-Lu AF11167|DRUG: Lu AF11167 MR tablet prototype formulation selected from part A or 1 mg modified release tablet (reference formulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Moxibustion-Induced Thermal Transport Effect Between The Heart And Lung Meridians
Status: COMPLETED
Conditions: Meridians
Interventions: PROCEDURE: Moxibustion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Expanded Access Program for Tafasitamab (MOR00208) in R/R DLBCL
Status: APPROVED_FOR_MARKETING
Conditions: DLBCL
Interventions: BIOLOGICAL: Tafasitamab, 12 mg/kg. 4 week cycles: weekly (Cycle 1-3) to bi-weekly (Cycle 4 onwards), loading dose Cycle 1, day 4. Cycle 4 onwards day 1, day 15 until disease progression
Study Type: EXPANDED_ACCESS
Clinical trial: CNS Penetration, PK and PD of Preoperative CC-90010 in Progressive/Recurrent Diffuse Astrocytoma, Anaplastic Astrocytoma and Glioblastoma
Status: TERMINATED
Conditions: Astrocytoma|Glioblastoma
Interventions: DRUG: CC-90010
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Myfortic in Combination With Tacrolimus and Thymoglobulin in Early Corticosteroid Withdrawal
Status: COMPLETED
Conditions: End Stage Renal Disease (ESRD)
Interventions: DRUG: Mycophenolic Acid (Myfortic)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strategy for Prompt and Effective Thoracentesis in the Emergency Department
Status: RECRUITING
Conditions: Pleural Effusion|Pleural Diseases|Heart Failure
Interventions: PROCEDURE: Gravity fluid drainage in the radiology department|PROCEDURE: Manual drainage in the emergency department
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Doin (Conduction Exercise) of the Pelvic Joint for HLD With Radiating Leg Pain
Status: COMPLETED
Conditions: Intervertebral Disc Displacement|Sciatica|Sciatic Radiculopathy
Interventions: PROCEDURE: Doin (conduction exercise)|DRUG: Herbal medicine|PROCEDURE: Chuna manual therapy|PROCEDURE: Bee venom pharmacopuncture|PROCEDURE: Pharmacopuncture|PROCEDURE: Acupuncture|PROCEDURE: Electroacupuncture|PROCEDURE: Cupping|OTHER: Other intervention(s)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: First in Man Study of ALX-0651, a Nanobody Inhibiting CXCR4
Status: TERMINATED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: ALX-0651|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Added D-fagomine on Glycaemic Responses to Sucrose
Status: COMPLETED
Conditions: Reduction of Post-prandial Glycaemic Response
Interventions: OTHER: D-fagomine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reactogenicity, Safety and Immunogenicity of QazCoVac-P COVID-19 Vaccine
Status: COMPLETED
Conditions: Covid19|SARS-CoV Infection|Vaccine Adverse Reaction
Interventions: BIOLOGICAL: QazCoVac-P -COVID-19 Subunit Vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: VitalPAD: an Intelligent Monitoring and Communication Device to Optimize Safety in the PICU
Status: WITHDRAWN
Conditions: Medical Device|User-Computer Interface|Critical Care|Physiologic Monitoring
Interventions: DEVICE: VitalPAD|DEVICE: Traditional tools
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: High-dose Furmonertinib for First-line Treatment of EGFR Mutated NSCLC With Central Nervous System (CNS) Metastases
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Furmonertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metoprolol to Reduce Perioperative Myocardial Injury
Status: COMPLETED
Conditions: Heart Diseases
Interventions: DRUG: Metoprolol Tartrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Followed by Surgery in Treating Patients With Stomach Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: cisplatin|DRUG: floxuridine|DRUG: irinotecan hydrochloride|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of Daratumumab for Decreasing Circulating Antibodies in Sensitized Patients Awaiting Heart Transplantation
Status: WITHDRAWN
Conditions: Allosensitization|Heart Transplant Failure and Rejection
Interventions: DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Using the Environmental Exposure Unit (EEU) to Assess the Onset of Action of Ciclesonide, Applied as a Nasal Spray in the Treatment of Seasonal Allergic Rhinitis (BY9010/M1-407)
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal|Hay Fever
Interventions: DRUG: Ciclesonide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of DLBS2411 in Healthy Volunteers
Status: COMPLETED
Conditions: Gastric pH Regulation in Healthy Volunteers
Interventions: DRUG: DLBS2411|DRUG: DLBS2411|DRUG: Placebo DLBS2411
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Simulation Training for Labor and Delivery Providers to Address HIV Stigma During Childbirth in Tanzania
Status: COMPLETED
Conditions: Hiv|Stigmatization|Pregnancy Related
Interventions: BEHAVIORAL: MAMA Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Subcutaneous Bevacizumab in Relapsed / Progressive Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: Bevacizumab 25 mg in 1 ml subcutaneously daily
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Distraction Versus Positive Pre-Visit Imagery Intervention on Children's Dental Fear and Anxiety
Status: UNKNOWN
Conditions: Nurse's Role
Interventions: BEHAVIORAL: Virtual Reality Distraction|BEHAVIORAL: Positive Pre-Visit Imagery Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Trial Testing the Efficacy of PDT in Preventing Amputation in Diabetic Patients
Status: COMPLETED
Conditions: Diabetic Foot Infection|Osteomyelitis|Photo Antimicrobial Chemotherapy
Interventions: RADIATION: PDT|OTHER: Ciprofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Montelukast in the Treatment of Duodenal Eosinophilia
Status: COMPLETED
Conditions: Eosinophilic Gastroenteritis|Dyspepsia
Interventions: DRUG: montelukast
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: PAKT: AZD5363 in Combination With Paclitaxel in Triple-Negative Advanced or Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Paclitaxel|DRUG: AZD5363|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of ANP Therapy vs. TMZ for Optic Pathway Glioma
Status: WITHDRAWN
Conditions: Optic Nerve Glioma
Interventions: DRUG: Temozolomide|DRUG: ANP Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Vitamin D Supplementation on COVID-19 Recovery
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Vit-D 0.2 MG/ML Oral Solution [Calcidol]|DRUG: Physiological Irrigating Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: 4SCAR-T Therapy Targeting GD2, PSMA and CD276 for Treating Neuroblastoma
Status: UNKNOWN
Conditions: Neuroblastoma
Interventions: BIOLOGICAL: GD2, PSMA and CD276 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Tivozanib in Combination With Nivolumab to Tivozanib Monotherapy in Subjects With Renal Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Tivozanib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caffeine Citrate in Preterm Infants at Risk of Apnea in Zambia
Status: NOT_YET_RECRUITING
Conditions: Premature Infant Disease|Apnea of Prematurity|Development, Infant
Interventions: DRUG: Caffeine citrate 20mg/kg/day|DRUG: Placebo-Sterile water 1ml/kg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy Trial of a Vaccine to Prevent Herpes Zoster in Adults Over 40 Years of Age
Status: COMPLETED
Conditions: Herpes Zoster
Interventions: BIOLOGICAL: One shot of the varicella-zoster virus vaccine|BIOLOGICAL: one shot of placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Mobile Health Intervention to Support Oral Chemotherapy Adherence in Adolescents and Young Adults With Leukemia
Status: NOT_YET_RECRUITING
Conditions: Acute Lymphoblastic Leukemia
Interventions: BEHAVIORAL: AYA ADAPTS (ADherence Assessments and Personalized Timely Support).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Mobile Intervention for Breast Feeding Counseling (MIBFc) in Primiparous Mothers
Status: UNKNOWN
Conditions: Breast Feeding, Exclusive
Interventions: DEVICE: Mobile intervention of breastfeeding counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study of TACI（Transmembrane Activator and Calcium-modulator and Cyclophilin Ligand (CAML) Interactor）-Antibody Fusion Protein Injection (RC18) in Subjects With Systemic Myasthenia Gravis
Status: COMPLETED
Conditions: Systemic Myasthenia Gravis
Interventions: BIOLOGICAL: RC18 160mg|BIOLOGICAL: RC18 240 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir in Adults With Genotype 1b Chronic Hepatitis C Virus (HCV) Infection and Cirrhosis
Status: COMPLETED
Conditions: Chronic Hepatitis C Infection|Compensated Cirrhosis
Interventions: DRUG: Ombitasvir/Paritaprevir/Ritonavir|DRUG: Dasabuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Augmented CBGT for Perinatal Anxiety During a Global Pandemic (COVID-19)
Status: COMPLETED
Conditions: Perinatal Anxiety|Covid19
Interventions: OTHER: Cognitive Behavioural Group Therapy for Perinatal Anxiety
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Rosuvastatin for Preventing Myocardial Damage in Patients With ACS
Status: UNKNOWN
Conditions: Acute Coronary Syndrome|Angioplasty
Interventions: DRUG: additional rosuvastatin loading|DRUG: placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: CART-PSMA-TGFβRDN Cells for Castrate-Resistant Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: CART-PSMA-TGFβRDN cells|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab and Chemotherapy With or Without Radiation in Small Cell Lung Cancer (SCLC)
Status: TERMINATED
Conditions: Small Cell Lung Cancer (SCLC)
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Etoposide|RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simvastatin in Colorectal Surgery
Status: COMPLETED
Conditions: Intestinal Neoplasm|Perioperative Care
Interventions: DRUG: Simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Multiple Doses of Itraconazole, Gemfibrozil, or Carbamazepine on BMS-986278 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: BMS-986278|DRUG: Itraconazole|DRUG: Gemfibrozil|DRUG: Carbamazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Head Positioning After Retina Detachment Repair
Status: RECRUITING
Conditions: Retina; Detachment, Rhegmatogenous
Interventions: DEVICE: Retina re-attachment repair using C3F8 gas tamponade
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Combination of Romidepsin and Carfilzomib in Relapsed/Refractory Peripheral T Cell Lymphoma Patients
Status: COMPLETED
Conditions: Peripheral T Cell Lymphoma
Interventions: DRUG: Romidepsin|DRUG: Carfilzomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Study Generic Tacrolimus Ointment, 0.1% in the Treatment of Moderate to Severe Atopic Dermatitis (Inflammation of Skin: Itchy, Red, Swollen, and Cracked Skin)
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Tacrolimus Ointment 0.1%|DRUG: Protopic® ointment, 0.1%|DRUG: Placebo of Tacrolimus Ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Intervention Designed to Enhance the Quality of Decision Support Provided to Patients Making Decisions About End-of-life Place of Care
Status: COMPLETED
Conditions: Palliative Care
Interventions: BEHAVIORAL: Decision support skills building Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Endobronchial Ultrasound vs Mediastinoscopy in NSCLC
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: PROCEDURE: Endobronchial Ultrasound Guided Transthoracic Needle Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Collecting Information About Treatment Results for Patients With Cushing's Syndrome
Status: RECRUITING
Conditions: Cushing's Disease|Cushing Syndrome|Cushing Disease
Interventions: OTHER: Cushing's QoL (Quality of Life Questionnaire)|OTHER: Nottingham Health Profile (NHP)|OTHER: Hospital Anxiety and Depression Scale (HADS)|OTHER: Perceived Stress Scale (PSS)|OTHER: Barratt's Impulsivity Scale (BIS)|OTHER: Beck Depression Inventory (BDI)|OTHER: State-Trait Anxiety Inventory (STAI)|OTHER: State Food Craving Questionnaire-State (FCQ-S)|OTHER: Trait Food Craving Questionnaire-Trait (FCQ-T)|OTHER: Visual Analogue Scale (VAS)|OTHER: Sensitivity to Reinforcement of Addictive and other Primary Rewards (STRAP-R) food variant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Dynamic Effect of Non-cytochrome P450 Isoenzyme 3A4（CYP3A4）-Metabolized and Cytochrome P450 Isoenzyme 3A4（CYP3A4）-Metabolized Statins on Clopidogrel Resistance in Patients With Cerebral Infarction
Status: UNKNOWN
Conditions: Cerebral Infarction|Clopidogrel,Poor Metabolism of (Disorder)
Interventions: DRUG: atorvastatin and clopidogrel|DRUG: rosuvastatin and clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proellex® Pharmacokinetic Bridging Study II
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Proellex 25 mg formulation A|DRUG: Proellex 25 mg formulation B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Use of Cranberries in Recurrent Bacterial Cystitis in Women
Status: UNKNOWN
Conditions: Recurrent Urinary Tract Infections in Women
Interventions: OTHER: Cysticlean|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Improving Prosthetic Provision in Rural Communities: Limb Scanning With Caregiver Assistance
Status: RECRUITING
Conditions: Lower Extremity Amputation
Interventions: DEVICE: Caregiver socket|DEVICE: Prosthetist socket
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Transcutaneous Electrical Nerve Stimulation in Peripheral Artery Disease TENS-PAD Study / TENS-AOMI
Status: TERMINATED
Conditions: Peripheral Artery Disease
Interventions: DEVICE: Transcutaneous electrical nerve stimulation (TENS)|DEVICE: SHAM Transcutaneous electrical nerve stimulation (TENS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HPI (Hypotension Prediction Index) Care Trial
Status: RECRUITING
Conditions: Cardiopulmonary Bypass Surgery
Interventions: DEVICE: AcumenTM HPI Software Feature|OTHER: Non-protocolized Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prostatic Artery Embolization Versus 532 nm Green Light PVP for Catheterized Patients
Status: UNKNOWN
Conditions: Benign Prostate Hyperplasia|Urinary Retention
Interventions: PROCEDURE: Green light PVP|PROCEDURE: Prostatic artery embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BE Study of Two Formulations of Rivaroxaban 2.5 mg in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: YHP1807 Tab. 2.5mg|DRUG: YHR1901 Tab. 2.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory PK and Imaging Study of PSMA-Targeted Trillium Compounds and PTI-122 in Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: PSMA-Targeted [In-111]-Labeled Trillium Compound|DRUG: PTI-122
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase 1 Biomarker Study of Anti-PDL-1 in Advanced Melanoma
Status: WITHDRAWN
Conditions: Stage III or IV Melanoma
Interventions: BIOLOGICAL: BMS-936559 (Anti-PD-L1)|BIOLOGICAL: BMS-936559 (Anti-PD-L1)|BIOLOGICAL: BMS-936559 (Anti-PD-L1)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparative Research Among 3 Action Protocol in Other to Approach Chronic Lateral Epicondyle Tendinopathy
Status: UNKNOWN
Conditions: Tendinopathy
Interventions: OTHER: Group of Dry Needling|OTHER: Group of Electrolysis|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Research Development（RD）13-02 Chimeric Antigen Receptor(CAR) -T Cell Injection for Patients With r/r Cluster Of Differentiation 7（CD7）+ T-Acute Lymphoblastic Leukemia(ALL)/T-Lymphoblastic Lymphoma(LBL) /Acute Myelogenous Leukemia(AML)
Status: RECRUITING
Conditions: Neoplasms|Hematologic Neoplasms|Hematologic Diseases
Interventions: DRUG: RD13-02 cell infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Neuromuscular Electrical Stimulation Program on Walking Capacity in Peripheral Artery Disease Patients
Status: COMPLETED
Conditions: Arteriopathy
Interventions: DEVICE: neuromuscular electrical stimulator|OTHER: Walking sessions|OTHER: Advices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Rhubarb on Sepsis and Post-traumatic Gastrointestinal Function Failure
Status: UNKNOWN
Conditions: Sepsis
Interventions: DRUG: Rheum Palmatum Root|DRUG: Starch Corn
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endovascular Therapy in Acute Ischaemic Stroke Due to Large Vessel Occlusion
Status: COMPLETED
Conditions: Acute Ischaemic Stroke
Interventions: DEVICE: Aspiration First|DEVICE: Stent retriever first
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ruxolitinib vs Best Available Therapy (BAT) in Patients With Steroid-refractory Chronic Graft vs. Host Disease (GvHD) After Bone Marrow Transplantation (REACH3)
Status: COMPLETED
Conditions: Graft-versus-host Disease (GVHD)
Interventions: DRUG: Ruxolitinib|DRUG: Extracorporeal photopheresis (ECP)|DRUG: Low-dose methotrexate (MTX)|DRUG: Mycophenolate mofetil (MMF)|DRUG: mechanistic Target of Rapamycin (mTOR) inhibitors (everolimus or sirolimus)|DRUG: Infliximab|DRUG: Rituximab|DRUG: Pentostatin|DRUG: Imatinib|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanisms and Treatment of Post-amputation Neuropathic Pain
Status: TERMINATED
Conditions: Neuropathic Pain|Phantom Limb Pain|Amputation
Interventions: DRUG: Spinal anaesthesia (sub-study 1)|DEVICE: Repetitive transcranial magnetic stimulation (sub-study 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Panobinostat in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: panobinostat|GENETIC: gene expression analysis|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Protocol of Tucatinib With Capecitabine and Trastuzumab in Patients With Unresectable Previously Treated HER2+ Breast Cancer
Status: APPROVED_FOR_MARKETING
Conditions: HER2-positive Breast Cancer
Interventions: DRUG: Tucatinib|DRUG: Capecitabine|DRUG: Trastuzumab
Study Type: EXPANDED_ACCESS
Clinical trial: Randomized Pilot Study Evaluating Isopropyl Alcohol and UVC Rays in Disinfection of Cell Phones
Status: RECRUITING
Conditions: Cross Infection
Interventions: DEVICE: isopropyl alcohol wipes|DEVICE: UVC box
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Autogenous Periosteal Pedicle Graft and Collagen Membrane in Management of Periodontal Intrabony Defects
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: PROCEDURE: Periosteal pedicle graft|BIOLOGICAL: Bioresorbable collagen membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Police Training to Reduce Occupational Needlesticks and HIV Among Substance Users
Status: COMPLETED
Conditions: Occupational Needlestick Injuries
Interventions: BEHAVIORAL: Police Education Program designed to align law enforcement and HIV prevention in Tijuana
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Prospective Study of Femtosecond Laser Intracorneal Lensectomi
Status: COMPLETED
Conditions: Myopia|Astigmatism
Interventions: DEVICE: Carl Zeiss Meditech VisuMax laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: New Imaging Tools to Explore Impact of Bariatric Surgery on Pancreatic Lesions: PACHIBA- Bariatric Surg
Status: UNKNOWN
Conditions: Bariatric Surgery
Interventions: RADIATION: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clopidogrel And Ticagrelor in Healthy Subjects
Status: COMPLETED
Conditions: Pharmacodynamics
Interventions: DRUG: Ticagrelor 90 mg|DRUG: Clopidogrel 600 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Use of Virtual Reality and Video Games in the Physiotherapy Treatment of Stroke Patients
Status: COMPLETED
Conditions: Stroke|Virtual Reality|Physical Therapy
Interventions: OTHER: Virtual reality and video games|OTHER: Neurological physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paraffin Wax Bath With Joint Mobilization Technique in Post-traumatic Stiff Knee
Status: COMPLETED
Conditions: Knee Pain Chronic
Interventions: OTHER: Paraffin wax bath therapy and Maitland joint mobilization techniques|OTHER: Maitland knee joint mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Trial of Clazakizumab in Late ABMR
Status: COMPLETED
Conditions: Antibody-mediated Rejection
Interventions: DRUG: Clazakizumab / Clazakizumab|DRUG: Placebo / Clazakizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: UCN-01 and Gemcitabine in Treating Patients With Unresectable or Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage II Pancreatic Cancer|Stage III Pancreatic Cancer|Stage IV Pancreatic Cancer
Interventions: DRUG: 7-hydroxystaurosporine|DRUG: gemcitabine hydrochloride|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders.
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: placebo|DRUG: varenicline tartrate|DRUG: bupropion hydrochloride|DRUG: Nicotine Replacement Therapy Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Comparison of Licorice Versus Sugar-water Gargle for Prevention of Postoperative Sore Throat and Postextubation Coughing
Status: COMPLETED
Conditions: Sore Throat
Interventions: OTHER: licorice solution|OTHER: sugar solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment of the Impact of Oral Intervention With Cetylpyridinium Chloride to Decrease SARS-CoV-2 Viral Load in Patients With COVID-19
Status: COMPLETED
Conditions: COVID-19|SARS-CoV-2 Infection
Interventions: OTHER: ORAL INTERVENTION WITH CETYLPYRIDINIUM CHLORIDE|OTHER: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Implementation of Multifaceted Patient-Centered Treatment Strategies for Intensive Blood Pressure Control in Minimize Cognitive Decline
Status: RECRUITING
Conditions: Hypertension|Cognitive Decline
Interventions: BEHAVIORAL: Stepped-care protocol adapted from the SPRINT intensive-treatment algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Pharmacodynamic Study of GET 73 in Alcohol Dependent
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: GET 73|DRUG: inactive ingredients capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inspiratory Muscle Training in Nemaline Myopathy
Status: COMPLETED
Conditions: Nemaline Myopathy|Inspiratory Muscle Training
Interventions: DEVICE: Threshold IMT, Philips Respironics, Murrysville, PA, USA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vandetanib in Combination With Metformin in People With HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell Carcinoma
Status: TERMINATED
Conditions: Renal Cell Carcinoma|Hereditary Leiomyomatosis|Renal Cell Cancer
Interventions: DRUG: Vandetanib|DRUG: Metformin|DRUG: Vandetanib/Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of D064 and D701 Combination Therapy
Status: RECRUITING
Conditions: Essential Hypertension
Interventions: DRUG: D064, D701, placebo of D012|DRUG: D012, placebo of D064, placebo of D701
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Nasal Endoscope Sterilization Using a Novel Rig-S™ Device
Status: COMPLETED
Conditions: Sterility
Interventions: DEVICE: Novel rig-S|DEVICE: Conventional Autoclave machine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Relationship of Spine Posture and Mobility With Upper Extremity Functions in Parkinson's Patients
Status: COMPLETED
Conditions: Parkinson|Posture|Upper Extremity|Quality of Life
Interventions: DEVICE: Spinal Mouse (IDIAG M360 )|OTHER: Nine Hole Peg Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparing the Hydrodynamic Piezoelectric Technique With Osseodensification for the Assessment of Internal Sinus Iift-ing
Status: COMPLETED
Conditions: Bone Density, Low
Interventions: PROCEDURE: internal sinus lift surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Baduanjin on Functional Performance in Pre-Frail/Frail Older Adults
Status: COMPLETED
Conditions: Frailty|Frail Elderly Syndrome
Interventions: OTHER: Baduanjin exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside
Status: NOT_YET_RECRUITING
Conditions: Alzheimer Disease|Dementia Alzheimers|Dementia|Cognitive Impairment|Mild Cognitive Impairment|Neurodegenerative Diseases|Neurocognitive Disorders|Neurocognitive Dysfunction|Cognitive Dysfunction|Mental Disorder
Interventions: DEVICE: Emerald Device Monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Early Versus Delayed Surgery for Infantile Esotropia
Status: COMPLETED
Conditions: Esotropia
Interventions: PROCEDURE: mVEP Testing|PROCEDURE: Stereoacuity Testing|PROCEDURE: Optokinetic nystagmus testing|PROCEDURE: Motion detection testing|PROCEDURE: Motion discrimination testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Biobased Polyester Versus Synthetic Fiberglass Casts for Treating Stable Upper Limb Fractures in Children
Status: COMPLETED
Conditions: Upper Limb Fracture
Interventions: OTHER: the biobased polyester cast|OTHER: the synthetic fiberglass cast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Canola Protein Processing on Plasma Amino Acid Responses
Status: RECRUITING
Conditions: Protein Metabolism Disorder
Interventions: DIETARY_SUPPLEMENT: 20g whey protein drink ingestion|DIETARY_SUPPLEMENT: 20g native canola protein drink ingestion|DIETARY_SUPPLEMENT: 20g processed canola protein #1 drink ingestion|DIETARY_SUPPLEMENT: 20g processed canola protein #2 drink ingestion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nutritional Needs and Intake on Clinical Outcomes in Mechanically Ventilated Critically Ill Elderly Patients
Status: COMPLETED
Conditions: Critical Illness|Mechanical Ventilation|Elderly
Interventions: DIETARY_SUPPLEMENT: high protein enteral nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals
Status: COMPLETED
Conditions: Cryptococcal Meningitis|HIV Infections
Interventions: DRUG: Fluconazole|DRUG: Amphotericin B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Recurrence of Diverticulitis
Status: COMPLETED
Conditions: Diverticulitis
Interventions: DRUG: SPD476, MMX™ mesalazine, 1.2g extended release tablet|DRUG: SPD476, MMX™ mesalazine, 2.4g extended release tablet|DRUG: SPD476, MMX™ mesalazine, 4.8g extended release tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Performance of the SpherePVI™ Catheter to Treat Paroxysmal Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: SpherePVI™ Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anesthesia on Gut Microbiota and Metabolomics
Status: UNKNOWN
Conditions: Hepatic Tumor Resection
Interventions: DRUG: Propofol|DRUG: Desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy Study of HO/03/03 10-40 Micro Grams to Treat Hard to Heal Wounds
Status: UNKNOWN
Conditions: Hard to Heal Wounds
Interventions: DRUG: HO/03/03 10-40 µg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Remote Ischemic Conditioning Combined EDAS on Ischemic Moyamoya Disease
Status: UNKNOWN
Conditions: Moyamoya Disease
Interventions: OTHER: RIC plus EDAS|OTHER: EDAS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Lebrikizumab in Adolescent Participants With Uncontrolled Asthma Who Are on Inhaled Corticosteroids and a Second Controller Medication
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Lebrikizumab|DRUG: Placebo|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CTLA-4 and PD-1 Antibodies Expressing Mesothelin-CAR-T Cells for Mesothelin Positive Advanced Solid Tumor
Status: UNKNOWN
Conditions: Advanced Solid Tumor
Interventions: BIOLOGICAL: CTLA-4/PD-1 antibodies expressing mesoCAR-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Cladribine, Cytarabine, Mitoxantrone, Filgrastim (CLAG-M) in Relapsed Acute Lymphoblastic Leukemia
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia|Lymphoblastic Lymphoma|Burkitts Leukemia/Lymphoma|Chronic Myelogenous Leukemia
Interventions: DRUG: CLAG-M|DRUG: CLAG-M
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Dietary Absorptive Capacity of Fructans in Healthy Subjects - A Dose Response Study
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: Fructan - 7.5|DIETARY_SUPPLEMENT: Fructan - 10|DIETARY_SUPPLEMENT: Fructan - 12.5|DIETARY_SUPPLEMENT: Fructan -- 5 grams
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Output Autonomic Stimulation Therapy for Acute Heart Failure (COAST-AHF)
Status: UNKNOWN
Conditions: Heart Failure Acute
Interventions: DEVICE: NeuroTronik CANS Therapy™ System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study of Adoptive Immunotherapy With Autologous Tumor Infiltrating Lymphocytes in Solid Tumors
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma|Hepatocellular Carcinoma|Breast Carcinoma
Interventions: BIOLOGICAL: tumor infiltrating lymphocytes, IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fasting Study of Quinapril Hydrochloride Tablets 40 mg and Accupril® Tablets 40 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Quinapril Hydrochloride Tablets 40 mg|DRUG: Accupril® Tablets 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Whey-Based Partially Hydrolyzed Formula Versus Polymeric Formula On Undernourished Neurologically Impaired Children: Open-labelled Randomized Study
Status: COMPLETED
Conditions: Nutrition Disorder, Child|Neurologic Disorder
Interventions: DIETARY_SUPPLEMENT: Whey-Based Partially Hydrolyzed Formula|DIETARY_SUPPLEMENT: received 50% of their caloric requirements as isocaloric polymeric formula (standard ) and 50% standard nutritional feeding according to ESPGHAN guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Transdermal Fentanyl Patches in Relief of Acute Postoperative Pain After Mastectomy
Status: UNKNOWN
Conditions: Breast Cancer Female
Interventions: DRUG: The Transdermal Therapeutic System-Fentanyl (TTS-F)|DEVICE: Intravenous patient-controlled analgesia (PCA) morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Assess the PK and Pharmacodynamics of IPX203 in Patients With Advanced Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: CD-LD IR|DRUG: IPX203 180 mg|DRUG: IPX203 270 mg|DRUG: Rytary 195 mg|DRUG: Rytary 145 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Bioavailability Study of Tablet and Granule Formulations of ADC189 and the Study of Ultra-high Dose
Status: RECRUITING
Conditions: Healthy Volunteer
Interventions: DRUG: ADC189 tablet|DRUG: ADC189 granules|DRUG: ADC189 180mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase 1 Study to Evaluate the Potential Drug Interactions Between Repotrectinib and Metformin, Digoxin, and Rosuvastatin in Patients With Advanced Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced Solid Tumor|Metastatic Solid Tumor
Interventions: DRUG: TPX-0005|DRUG: Metformin Hydrochloride|DRUG: Digoxin|DRUG: Rosuvastatin Calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect Of Acute Inflammatory Mediators On Functional Limitations In Patients With Acute Respiratory Failure
Status: COMPLETED
Conditions: Acute Respiratory Failure
Interventions: OTHER: Early ICU rehabilitation strategies|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing the Risk of P. Vivax After Falciparum Infections in Co-endemic Areas
Status: COMPLETED
Conditions: Malaria|Vivax Malaria|Falciparum Malaria
Interventions: DRUG: primaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simplified Pulse Wave Velocity Measurement, Validation Study of the pOpmètre in Children
Status: COMPLETED
Conditions: Cardiovascular Diseases|Arteriosclerosis|Atherosclerosis
Interventions: DEVICE: pOpmètre®|DEVICE: Sphygmocor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: ED-LEAD: Emergency Departments Leading the Transformation of Alzheimer's and Dementia Care
Status: NOT_YET_RECRUITING
Conditions: Alzheimer's Disease Related Dementia|Alzheimer Disease
Interventions: BEHAVIORAL: Emergency Care Redesign (ECR)|BEHAVIORAL: Nurse-led Telephonic Care (NLTC)|BEHAVIORAL: Community Paramedic-led Transitions Intervention (CPTI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Axitinib Intensification Plus Nivolumab or Nivolumab Alone After Nivolumab Plus Ipilimumab in mRCC Patients
Status: RECRUITING
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: Axitinib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT