pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of Belinostat in Combination With Warfarin in Patients With Solid Tumors or Hematological Malignancies
Status: COMPLETED
Conditions: Solid Tumor|Hematological Malignancy
Interventions: DRUG: Belinostat, Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Capecitabine, Oxaliplatin, Cetuximab, and Radiation Therapy for Locally Advanced Esophageal Adenocarcinoma
Status: TERMINATED
Conditions: Esophageal Adenocarcinoma
Interventions: DRUG: Capecitabine|DRUG: Oxaliplatin|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate AB-1001 Striatal Administration in Adults With Early Manifest Huntington's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Huntington Disease
Interventions: GENETIC: AB-1001 Gene Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerance of Umbilical Cord Mesenchymal Stem Cells in Patients With Acute Respiratory Distress Syndrome
Status: NOT_YET_RECRUITING
Conditions: Acute Respiratory Distress Syndrome
Interventions: BIOLOGICAL: Human Umbilical Cord Mesenchymal Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TARGTEPO Treatment for Anemia in Chronic Kidney Disease (CKD) Patients and End-Stage Renal Disease (ESRD)
Status: COMPLETED
Conditions: Chronic Kidney Disease|End Stage Renal Disease
Interventions: BIOLOGICAL: MDGN201 TARGTEPO
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation for the Prevention of GDM
Status: RECRUITING
Conditions: Vitamin D|Gestational Diabetes
Interventions: DRUG: Vitamin D3|DRUG: The placebo(not contain vitamin D)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Development of a Neonatal Jaundice Treatment Accelerator by Redirection of Unused Light During Phototherapy
Status: WITHDRAWN
Conditions: Jaundice|Jaundice, Neonatal
Interventions: DEVICE: Ring Phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pivotal Study of Fexinidazole for Human African Trypanosomiasis in Stage 2
Status: COMPLETED
Conditions: Human African Trypanosomiasis (HAT)|Sleeping Sickness
Interventions: DRUG: Fexinidazole|DRUG: Nifurtimox|DRUG: Eflornithine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain in Oncolgy: Evaluation of a Non Invasive Monitoring Device (ANI). A Monocentric Prospective Study
Status: COMPLETED
Conditions: Pain|Cancer
Interventions: DEVICE: Non Invasive Monitoring Device (ANI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Benefits and Costs of Home-based Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: Home-based pulmonary rehabilitation|BEHAVIORAL: Hospital-based pulmonary rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study to Evaluate Monoclonal Antibody KW-0761 in Subjects With Peripheral T-cell Lymphoma
Status: COMPLETED
Conditions: Peripheral T-Cell Lymphoma
Interventions: BIOLOGICAL: KW-0761
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of CVN424
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: CVN424 75 mg|DRUG: CVN424 150 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Antiseptic in Newborn Circumcision Comparison of Povidone Iodine and Hypochlorous Acid Used
Status: COMPLETED
Conditions: Newborn; Infection|Disinfection|Circumcision
Interventions: DRUG: hypochlorous acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Therapeutic Effects of Dextrose Injection for Myofascial Pain Syndrome
Status: RECRUITING
Conditions: Myofascial Trigger Point Pain
Interventions: OTHER: normal saline|DRUG: Dextrose 5% in water|DRUG: Dextrose 15% in water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Embryo Assessment Utilizing Timelapse Imaging in Conjunction With Preimplantation Genetic Testing for Aneuploidy With Next Generation Sequencing
Status: RECRUITING
Conditions: Infertility, Female|Infertility, Male|Infertility|IVF|Aneuploidy
Interventions: DIAGNOSTIC_TEST: Timelapse incubation and PGT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Characterization of Metabolic and Brain Effects of Rising Glucagon During an Oral Glucose Challenge
Status: COMPLETED
Conditions: Metabolic Syndrome|Diabetes
Interventions: DRUG: Intravenous glucagon|DRUG: Intravenous saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intracoronary Stem Cell Therapy in Patients With Acute Myocardial Infarction (SCAMI)
Status: COMPLETED
Conditions: Acute Myocardial Infarction|Coronary Artery Disease
Interventions: OTHER: autologous stem cells|OTHER: placebo suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of AV2 Antiviral Drug on the Treatment of HPV-associated Lesions of the Uterine Cervix
Status: COMPLETED
Conditions: Uterine Cervical Dysplasia|Papillomavirus Infections
Interventions: DRUG: AV2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Student-delivered Telehealth Program for COVID-19 Education and Health Promotion
Status: COMPLETED
Conditions: Chronic Disease|Aging|Aging Problems|Health Behavior|Multiple Chronic Conditions|Chronic Illness|Chronic Illnesses, Multiple|Healthy Lifestyle|Healthy Aging|Aging Well|Healthy Life Style|Self-management|Self Care
Interventions: BEHAVIORAL: Telehealth coaching sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Theophylline and Steroids in Chronic Obstructive Pulmonary Disease (COPD) Study
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Theophylline|DRUG: Prednisone|DRUG: Placebo (for prednisone)|DRUG: Placebo (for Theophylline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Long-term Efficacy (24 Weeks) of MPC-4326 in Combination With a 2-3 Drug OBR Relative to the Efficacy of a 3-4 Drug ARV Regimen in Treatment Experienced HIV-1 Infected Subjects Who Are Failing Current Antiretroviral Therapy
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: MPC-4326 plus a 2-3 drug optimized background regimen (OBR)|DRUG: 3-4 commercially available antiretroviral drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Pranayama and Deep Breathing Exercises to Reduce Cancer-Related Fatigue and Insomnia During Radiotherapy
Status: COMPLETED
Conditions: Breast Cancer|Fatigue|Insomnia
Interventions: OTHER: breathing exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Aripiprazole Versus Higher Metabolic Risk Antipsychotic Drugs on Adiposity Using MRI
Status: COMPLETED
Conditions: Psychotic Disorders|Bipolar Disorder|Metabolic Syndrome X
Interventions: DRUG: Aripiprazole|DRUG: Risperidone/Quetiapine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence Study of Daclatasvir From Daktavira 60 mg Film Coated Tablets ( European Egyptian Pharmaceutical Industries, Egypt) Versus Daklinza 60 mg Tablets (Bristol-Myers Squibb Pharma, UK)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Daktavira|DRUG: Daklinza
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Induced Suppression of Platelets Activity in Aneurysmal SAH Management (iSPASM)
Status: COMPLETED
Conditions: Subarachnoid Hemorrhage, Aneurysmal
Interventions: DRUG: tirofiban hydrochloride (AGGRASTAT®)|DIAGNOSTIC_TEST: MRI|DIAGNOSTIC_TEST: Neurological Exam|BEHAVIORAL: Questionnaires|DIAGNOSTIC_TEST: Vital Signs|OTHER: Standard of Care Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mars Flavanol Exercise and Cognitive Function Study
Status: COMPLETED
Conditions: Cognitive Function
Interventions: DIETARY_SUPPLEMENT: Flavanol containing food product|BEHAVIORAL: Aerobic training|DIETARY_SUPPLEMENT: Food product lacking flavanol|BEHAVIORAL: Wait list control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dexamethasone, Olanzapine, Hemodynamics, and Ventilation in Cardiac Surgery
Status: RECRUITING
Conditions: Coronary Artery Disease|Aortic Valve Disease
Interventions: DRUG: Dexamethasone phosphate|DRUG: Isotonic sodium chloride (0.9%)|DRUG: Olanzapine 10 MG|DRUG: Placebo capsule|PROCEDURE: Flow-targeted hemodynamic management|PROCEDURE: Pressure-targeted hemodynamic management|PROCEDURE: Low tidal-volume ventilation|PROCEDURE: No ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Screening Study to Collect Samples for TAA, HLA & HLA Loss of Heterozygosity in Patients With Metastatic Solid Tumors
Status: RECRUITING
Conditions: Head and Neck Cancer|Cervical Cancer|Non Small Cell Lung Cancer|Melanoma|Ovarian Cancer|HPV16 Related Cancers
Interventions: DIAGNOSTIC_TEST: Tumor and HLA Profiling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Estimate the Effect of aPDT on Root Canal Disinfection
Status: RECRUITING
Conditions: Root Canal Disinfection
Interventions: PROCEDURE: Rubber dam isolation|DEVICE: aPDT|DRUG: 1% iodine tincture|DRUG: 2.5%NaClO|PROCEDURE: root canal preparation|PROCEDURE: root canal obturation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adapt Monorail Carotid Stent System: A Postmarket Clinical Follow-up Study
Status: COMPLETED
Conditions: Carotid Artery Disease|Carotid Stenosis|Stroke
Interventions: DEVICE: Carotid Artery Stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selumetinib and Olaparib in Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Neoplasm of Breast|Malignant Neoplasms of Digestive Organs|Malignant Neoplasms of Female Genital Organs|Malignant Neoplasms of Male Genital Organs|Malignant Neoplasms of Thyroid and Other Endocrine Glands
Interventions: DRUG: Selumetinib|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adalimumab Drug Optimisation in Rheumatoid Arthritis Using Therapeutic Drug Monitoring
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DIAGNOSTIC_TEST: Adalimumab serum trough concentration|DIAGNOSTIC_TEST: Disease activity|DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Neoantigen Peptide Vaccine/Neoantigen-based DC to Treat Advanced Malignant Solid Tumors
Status: RECRUITING
Conditions: Advanced Malignant Solid Tumors
Interventions: DRUG: Neoantigen peptide vaccine|DRUG: Neoantigen-based DC immune preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Talazoparib in Asian Metastatic Breast Cancer Patients With a Homologous Recombinant Deficiency (HRD) Signature
Status: RECRUITING
Conditions: HRD 100 Gene Expression High|Triple Negative Breast Cancer
Interventions: DRUG: Talazoparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial of Bisacodyl Versus Placebo on Postoperative Bowel Motility in Elective Colorectal Surgery
Status: COMPLETED
Conditions: Postoperative Ileus
Interventions: DRUG: bisacodyl|DRUG: glucosemonohydricum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda
Status: COMPLETED
Conditions: Vernal Keratoconjunctivitis
Interventions: DRUG: Cyclosporine A|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Application and Optimization of the International Study Group of Pancreatic Surgery (ISGPS) Definition and Grading Criteria for Postoperative Complications of Pancreatic Surgery in Laparoscopic Pancreatic Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Laparoscopic Pancreatic Surgery|Pancreatic Fistula|Postoperative Bleeding|Delayed Gastric Emptying
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 3 Evaluation of the Safety and Efficacy of LNZ101 for the Treatment of Presbyopia
Status: COMPLETED
Conditions: Presbyopia|Refractive Error|Near Vision|Miosis|Eye Diseases
Interventions: DRUG: Aceclidine + Brimonidine|DRUG: Aceclidine|DRUG: Brimonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rapid Infusion Of Immune Globulin Intravenous (IGIV) In Patients With ITP
Status: COMPLETED
Conditions: Purpura, Thrombocytopenic, Idiopathic
Interventions: DRUG: Immune Globulin IV [Human], 10% Caprylate/Chromatography Purified
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erenumab-aooe for Temporomandibular Disorders Management: TMD Cgrp Antibody RElief (TMD CARE)
Status: TERMINATED
Conditions: Temporomandibular Disorders
Interventions: DRUG: Erenumab-Aooe 70 MG in 1 mL Prefilled Syringe|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: [18F] Fluorocholine FCH Positron Emission Tomography (PET)/Computed Tomography (CT) for Detection of Prostate Cancer Lymph Nodes Metastases
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: PROCEDURE: [18F] Fluorocholine PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Effect of cARvedilol Compared To bISoprolol on cenTral Pulse Pressure in Hypertension (ARTIST) Study
Status: UNKNOWN
Conditions: Hypertension
Interventions: DRUG: carvedilol|DRUG: bisoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Food INtake Effect of Hemp Protein (A FINEH Protein) Trial - Part 2
Status: COMPLETED
Conditions: Diabetes Prevention|Obesity Prevention
Interventions: DIETARY_SUPPLEMENT: Hemp Shake|DIETARY_SUPPLEMENT: Hemp|DIETARY_SUPPLEMENT: Soybean Shake|DIETARY_SUPPLEMENT: Soybean|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of BioEnterics® Intragastric Balloon (BIB®) System to Assist in the Weight Management of Obese Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: DEVICE: BioEnterics® Intragastric Balloon|OTHER: Behavioral modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Radiotherapy Combined With Tislelizumab and Irinotecan in MSS/pMMR Recurrence and Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Mismatch Repair-proficient|Colorectal Cancer Metastatic|Microsatellite Stable
Interventions: DRUG: Tislelizumab|DRUG: Irinotecan|RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: InTRaoperative Imaging DEvice Based on endogeNous opTical Properties to Evaluate Bowel Oxygenation in Colorectal Resections
Status: COMPLETED
Conditions: Left-sided Colorectal Resection : Diverticular Diseases|Left-sided Colorectal Resection : Colonic Neoplasms|Left-sided Colorectal Resection : Rectal Neoplasms
Interventions: DEVICE: use of the TRIDENT system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Clinical Evaluation of the Performance of a Difluoroethane-based Cyto-selective Cryotherapy to Treat Dark Spots on the Hand in 30 Volunteers.
Status: COMPLETED
Conditions: Solar Lentigo
Interventions: DEVICE: CRYOBEAUTY MAINS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Monitoring Devices in Prediction of Fluid Responsiveness in Severe Sepsis and Septic Shock
Status: UNKNOWN
Conditions: Severe Sepsis|Septic Shock
Interventions: DEVICE: NICOM/FloTrac|OTHER: Crystalloid Fluid Challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
Status: NOT_YET_RECRUITING
Conditions: Anxiety Disorders|Depression|Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: COGENT|OTHER: Sham Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Exposure of Simulated Hypoxia on Cognitive Function
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DEVICE: Simulated Altitude (FiO2: 15.1%)|DEVICE: Shamed Hypoxia (FiO2: 20.9)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: L-Thyroxine Supplementation for Preterm Newborns Less Than 32 Weeks of Gestation With Hypothyroxinemia
Status: COMPLETED
Conditions: Hypothyroxinemia
Interventions: DRUG: L-Thyroxine|DRUG: water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 16-week Efficacy and 2-year Safety, Tolerability and Efficacy of Secukinumab in Participants With Active Psoriatic Arthritis
Status: COMPLETED
Conditions: Arthritis, Psoriatic
Interventions: BIOLOGICAL: Secukinumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of mRNA Vaccine Formulation Against COVID-19 in Healthy Adults 18 Years of Age and Older
Status: TERMINATED
Conditions: COVID-19
Interventions: BIOLOGICAL: SARS-CoV-2 mRNA vaccine formulation 1|BIOLOGICAL: SARS-CoV-2 mRNA vaccine formulation 2|BIOLOGICAL: SARS-CoV-2 mRNA vaccine formulation 3|BIOLOGICAL: Placebo (0.9% normal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pamidronate, Vitamin D, and Calcium for the Bone Disease of Kidney and Heart Transplantation
Status: COMPLETED
Conditions: Transplant Bone Disease
Interventions: DRUG: Pamidronate|DRUG: vitamin D|DRUG: Calcium Carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Saline Water and Lidocaine Injections for the Treatment of Intractable Plantar Keratoma
Status: COMPLETED
Conditions: Intractable Plantar Keratoma
Interventions: DRUG: Lidocaine injection|DRUG: Physiological water injection|PROCEDURE: Debridement|PROCEDURE: Needle insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test if a Third Dose of the Vaccine is Safe in Current and Former Smokers Aged 40 to 80 Years Old and to Gather Information on the Immune Response Following the Third Dose of the Vaccine
Status: COMPLETED
Conditions: Respiratory Disorders
Interventions: BIOLOGICAL: NTHi Mcat investigational vaccine (GSK3277511A)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Assessing the Safety, Tolerability, Pharmacokinetics, Food Effect, and Drug-Drug Interactions of PTI-801 in Healthy Volunteers, and Safety, Tolerability, and Pharmacokinetics of PTI-801 in Subjects With Cystic Fibrosis
Status: COMPLETED
Conditions: Healthy Volunteer|Cystic Fibrosis
Interventions: DRUG: PTI-801|DRUG: Placebo|DRUG: PTI-808|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Once-weekly vs Twice-weekly Carfilzomib in Combination With Lenalidomide and Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: DRUG: Carfilzomib|DRUG: Carfilzomib|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Mucomyst to Ameliorate Oxidant Stress in Diabetics With Proteinuria
Status: COMPLETED
Conditions: Diabetes|Proteinuria
Interventions: DRUG: N-acetylcysteine(Mucomyst)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of GLP-1 Analogue Combined With Metformin and Metformin on Gonadal and Metabolic Profiles in Chinese Overweight/Obese PCOS Patients With Hyperandrogenemia.
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Metformin|DRUG: Exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Multi-cohort Study of the First Phase of Safety of a Drug Based on Double Recombinant Vaccinia Virus VV-GMCSF-Lact
Status: UNKNOWN
Conditions: Oncolytic Virotherapy
Interventions: BIOLOGICAL: Double Recombinant Vaccinia Virus VV-GMCSF-Lact
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tezepelumab in Patients With Eosinophilic Esophagitis
Status: RECRUITING
Conditions: Eosinophilic Esophagitis
Interventions: BIOLOGICAL: Tezepelumab|BIOLOGICAL: Tezepelumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AMPK-activation by Metformin in FSGS: AMP-FSGS
Status: RECRUITING
Conditions: Focal Segmental Glomerulosclerosis
Interventions: DRUG: Metformin + Standard of Care|OTHER: Placebo + Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hepatic Arterial Infusion With Melphalan Compared With Standard Therapy in Treating Patients With Unresectable Liver Metastases Due to Melanoma
Status: COMPLETED
Conditions: Intraocular Melanoma|Melanoma (Skin)|Metastatic Cancer
Interventions: DRUG: melphalan|DRUG: regional chemotherapy|DRUG: systemic chemotherapy|PROCEDURE: hepatic artery embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Immunogenicity of Co-administering Human Papillomavirus Vaccine With Another Vaccine in Healthy Female Subjects
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: BIOLOGICAL: Cervarix™|BIOLOGICAL: Twinrix ™ Paediatric
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Whole-Body Vibration Training On Thermal Burn Injury In Pediatrics
Status: RECRUITING
Conditions: Burns
Interventions: DEVICE: Whole Body Vibration Training Plus Conventional Physical Therapy Exercise Program.|OTHER: Conventional Physical Therapy Exercise Program.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Therapist and Parent Delivered Reciprocal Imitation Training for Young Children With Autism Spectrum Disorder
Status: SUSPENDED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Reciprocal Imitation Training (Therapist-Delivered)|BEHAVIORAL: Reciprocal Imitation Training (Therapist + Parent Delivered)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Radiation, Nelfinavir Mesylate & Neoadjuvant Chemotherapy in Locally Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Pancreas|Stage III Pancreatic Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: leucovorin calcium|DRUG: fluorouracil|DRUG: nelfinavir mesylate|RADIATION: stereotactic body radiation therapy|RADIATION: hypofractionated radiation therapy|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smoking Cessation Interventions for People Living With HIV in Nairobi, Kenya
Status: COMPLETED
Conditions: HIV|Smoking Cessation
Interventions: DRUG: Bupropion|BEHAVIORAL: Positively smoke free|OTHER: Brief advice to quit smoking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of KW-3902 on Diuresis in Subjects With Congestive Heart Failure (CHF).
Status: COMPLETED
Conditions: Heart Failure, Congestive
Interventions: DRUG: KW-3902IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Denosumab on the Pharmacokinetics (PK) of Midazolam
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis
Interventions: DRUG: Denosumab|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Monitoring of the Pelvic Autonomic Nerves
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: PROCEDURE: TME|PROCEDURE: TME|PROCEDURE: Neuromonitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Effects of Exenatide on Insulin Secretion Rates Using a Graded Infusion of Intravenous Glucose (0000-099)(COMPLETED)
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Comparator: Treatment A|DRUG: Comparator: Treatment B|DRUG: Comparator: Treatment C|PROCEDURE: Comparator: graded glucose infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Signaling Pathways
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Leucine supplementation|DIETARY_SUPPLEMENT: BCAA supplementation|DIETARY_SUPPLEMENT: Alanine supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302)
Status: RECRUITING
Conditions: Glioblastoma|Glioblastoma Multiforme|Glioblastoma, IDH-wildtype|Glioblastoma Multiforme of Brain|Glioblastoma Multiforme, Adult|Recurrent Glioblastoma|Astrocytoma, Malignant|Astrocytoma of Brain
Interventions: PROCEDURE: Re-resection|DRUG: Temozolomide|DRUG: Lomustine|RADIATION: Re-irradiation|PROCEDURE: Experimental therapy|OTHER: Best supportive care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Investigating Lu AG06474 in Healthy Young Participants
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: Lu AG06474|DRUG: Placebo|DRUG: Lu AG06474
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of McGrath MAC Versus C-MAC Videolaryngoscopes in Morbidly Obese Patients
Status: COMPLETED
Conditions: Difficult Intubation|Morbid Obesity|Videolaryngoscopy
Interventions: DEVICE: C-MAC videolaryngoscope|DEVICE: McGrath MAC videolaryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Biparametric MRI in Prostate Cancer Screening: a Noninferior Randomized Controlled Study
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: biparametric MRI (bpMRI)|DIAGNOSTIC_TEST: Prostate cancer antigen (PSA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Phase 2, Open-label, Study of KD025 in Subjects With Psoriasis Vulgaris Who Failed First-line Therapy
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: KD025
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A New Translational Tool for Studying the Role of Breathing in Meditation
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: Mindful Breathing (MB) Intervention|BEHAVIORAL: Usual Care (UC) Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the InterFACE-AR System for Cardiopulmonary Arrest: A Multicenter, Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Cardiopulmonary Arrest|Cardiac Arrest
Interventions: DEVICE: Augmented reality|DEVICE: LCD Screen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TOL-463 Phase 2 Study for Vaginitis
Status: COMPLETED
Conditions: Bacterial Vaginosis|Vulvovaginal Candidiasis
Interventions: DRUG: TOL-463|DRUG: TOL-463
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability of MK0217 in Women (0217-219)
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis
Interventions: DRUG: MK0217, alendronate sodium/Duration of Treatment: 6 months|DRUG: Comparator: placebo / Duration of Treatment: 6 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Aerobic Exercise and Spinal Stabilization Exercises in Women With Primary Dysmenorrhea
Status: UNKNOWN
Conditions: Primary Dysmenorrhea
Interventions: OTHER: Aerobic exercise program|OTHER: Spinal stabilization exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ABI-007 and Taxol in Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms|Metastases, Neoplasm
Interventions: DRUG: ABI-007
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apigenin in Increasing Health Benefits in High Risk Breast Clinic Patients
Status: WITHDRAWN
Conditions: Health Status Unknown
Interventions: PROCEDURE: Bio specimen Collection|DIETARY_SUPPLEMENT: Dietary Intervention|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Adipositas Care & Health Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Patients After Metabolic-bariatric Surgery|Obesity, Morbid
Interventions: OTHER: early aftercare|OTHER: mid-term to late aftercare
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Conversations as a Means to Delay the Onset of Alzheimer's Disease
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Cognitive Change
Interventions: BEHAVIORAL: Active social engagement group|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Awareness Among Hearing Enhancement Interventions and Reimbursement Criteria of Hearing Implants
Status: UNKNOWN
Conditions: Awareness|Hearing Impairment|Otorhinolaryngologic Surgical Procedures|Implant
Interventions: BEHAVIORAL: Interview
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Radiation Therapy With or Without Combination Chemotherapy Following Surgery in Treating Patients With Stage I or Stage II Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Cancer
Interventions: DRUG: cisplatin|DRUG: paclitaxel|PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Using MOST to Optimize an Intervention to Increase COVID-19 Testing for Frontline Essential Workers
Status: RECRUITING
Conditions: COVID-19|COVID-19 Testing
Interventions: BEHAVIORAL: Motivational interviewing (MI) counseling|BEHAVIORAL: Text messages (TMs) and quiz questions (QQs)|BEHAVIORAL: Peer education|BEHAVIORAL: Access to COVID testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Epidemiological Study to Monitor Study Participants With Resected Stage II (High Risk) or Stage III Colorectal Cancer for Circulating Tumor DNA Before, During and After Their Treatment With Adjuvant Chemotherapy
Status: RECRUITING
Conditions: Colorectal Cancer Stage II|Colorectal Cancer Stage III
Interventions: PROCEDURE: Regular blood sample collection for ctDNA assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety Lead-In Study of a Repurposed Drug Added to the Combination of Len Plus Pem
Status: NOT_YET_RECRUITING
Conditions: Advanced Endometrial Cancer
Interventions: DRUG: EG-007|DRUG: Pembrolizumab 100 mg/4 mL (25 mg/ml) Injection|DRUG: Lenvatinib Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Different Physical Therapy Modalities in Lateral Epicondylitis
Status: COMPLETED
Conditions: Lateral Epicondylitis
Interventions: BEHAVIORAL: Exercise|DEVICE: Kinesiotaping|DEVICE: High intensity laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Brain Activity Changes After Structured Cognitive-motor Exercise for People With Stroke
Status: RECRUITING
Conditions: Stroke
Interventions: BEHAVIORAL: Dual-task training|BEHAVIORAL: Single-task training|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fed Study of Oxybutynin Chloride Extended-release Tablets 10 mg and Ditropan XL® Tablets 10 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxybutynin Chloride ER Tablets 10 mg|DRUG: Ditropan XL® Tablets 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Learn More About the Potential of Antifungal Cream V61-044 Containing Trolamine to Cause Irritant Reaction of the Skin to Ultra Violet Light in Healthy Human Subjects
Status: COMPLETED
Conditions: Dermatitis, Phototoxic
Interventions: DRUG: Butenafine HCl 1% (BAY1896425)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Response in Psychosis Study
Status: TERMINATED
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder|Psychotic Disorder Not Otherwise Specified
Interventions: DRUG: long-acting injectable risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Radio Frequency Ablation Plus Chemotherapy and Chemotherapy Alone in Patients With Secondary Liver Metastases
Status: WITHDRAWN
Conditions: Metastatic Liver Cancer|Secondary Liver Cancer|Liver Neoplasm
Interventions: DEVICE: Radiofrequency Ablation (RFA)|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Diabetes Education Mobile Web Application on Patients With Uncontrolled Type 2 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Diabetes Education|Lifestyle Modification
Interventions: OTHER: Diabetes education web site application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Rehabilitation With or Without Static Progressive Splinting for Wrist Stiffness
Status: TERMINATED
Conditions: Post-traumatic Stiff Wrists
Interventions: DEVICE: Joint Active Systems (JAS) Static progressive splint|PROCEDURE: Rehabilitation without splinting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab and Acalabrutinib in Newly Diagnosed B Cell Post Transplant Lymphoproliferative Disorder
Status: TERMINATED
Conditions: Post-transplant Lymphoproliferative Disorder
Interventions: DRUG: Rituximab|DRUG: Acalabrutinib|DIAGNOSTIC_TEST: CT scans
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Eculizumab for Treatment of Antibody-mediated Rejection Following Renal Transplantation
Status: TERMINATED
Conditions: Antibody-mediated Rejection|Humoral Rejection
Interventions: DRUG: Eculizumab|BIOLOGICAL: Immunoglobulin|PROCEDURE: Plasmapheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of AI Wall Thickness Measurement (EchoNet-LVH-RCT)
Status: NOT_YET_RECRUITING
Conditions: Heart Failure
Interventions: DIAGNOSTIC_TEST: Sonographer Evaluation|DIAGNOSTIC_TEST: AI Evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Laser Acupuncture Augmented by Abdominal Exercises on Abdominal Fat
Status: COMPLETED
Conditions: Obesity, Abdominal
Interventions: OTHER: laser acupuncture and abdominal exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Augmented Whole-body Scanning Via Magnifying PET/CT (AWSM-PET/CT) Techniques Abilities to Improve Upon the Diagnostic Accuracy of the Standard-of-care (SOC) FDG PET/CT for Malignant Lesion Detection
Status: RECRUITING
Conditions: Cancer
Interventions: DEVICE: Augmented Whole-body Scanning via Magnifying PET|DEVICE: FDG-PET/CT|DRUG: 18F- fluorodeoxyglucose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sodium Bicarbonate Versus Saline for the Prevention of Contrast-induced Nephropathy
Status: COMPLETED
Conditions: Contrast-Induced Nephropathy
Interventions: DRUG: Sodium Bicarbonate|DRUG: Isotonic Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Trial of a Game Embedded in a Smartphone App for Smoking Cessation
Status: COMPLETED
Conditions: Cigarette Smoking-Related Carcinoma
Interventions: BEHAVIORAL: Game Module|BEHAVIORAL: Smoke Free smartphone application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Topical 3% Amphotericin B Cream for the Treatment of Cutaneous Leishmaniasis in Colombia
Status: COMPLETED
Conditions: Cutaneous Leishmaniasis
Interventions: DRUG: Topical Amphotericin B at 3%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Foam Rolling on Viscoelastic Tissue Properties and Fascial Sliding
Status: COMPLETED
Conditions: Fascia|Self-Myofascial-Release|Passive Stiffness|Fascial Sliding|Flexibility
Interventions: OTHER: Self-Myofascial-Release|OTHER: Stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine,Hydroxychloroquine,Azithromycin in the Treatment of SARS CoV-2 Infection
Status: TERMINATED
Conditions: Coronavirus Infection
Interventions: DRUG: Hydroxychloroquine Sulfate|DRUG: Azithromycin|DRUG: Chloroquine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Patients With Lupus Nephritis Using Kidney MRI (Magnetic Resonance Imaging)
Status: RECRUITING
Conditions: Lupus Nephritis|Lupus Erythematosus, Systemic|Lupus|SLE|SLE Nephritis|SLE; Glomerulonephritis (Etiology)|SLE (Systemic Lupus)
Interventions: DEVICE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Improving Social Interaction for Adolescents With Autism During the Transition to Adulthood
Status: TERMINATED
Conditions: Autism Spectrum Disorder|Typical Development
Interventions: DEVICE: tDCS|BEHAVIORAL: Autism Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: LCAR-T2C CAR-T Cells in Relapsed or Refractory CD4+ T Lymphocyte Tumor
Status: TERMINATED
Conditions: T Cell Lymphoma|T-cell Leukemia
Interventions: DRUG: Efficacy of LCAR-T2C CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-operative Cognitive Dysfunction and the Change of Regional Cerebral Oxygen Saturation in Elderly Patients Undergoing Spinal Surgery
Status: COMPLETED
Conditions: Elderly Patients Undergoing Spinal Surgery
Interventions: OTHER: Neurologic and neuropsychologic tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: SEVENFACT® for Bleeding Events in Hemophilia With Inhibitors
Status: RECRUITING
Conditions: Hemophilia A With Inhibitor|Hemophilia B With Inhibitor
Interventions: DRUG: coagulation factor VIIa [recombinant]-jncw
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT