pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Dexmedetomidine and Vasopressin in Septic Shock
Status: NOT_YET_RECRUITING
Conditions: Sepsis|Septic Shock
Interventions: DRUG: DEX-PRESSIN|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Interferon to Treat Patients Hospitalized for Influenza
Status: UNKNOWN
Conditions: Influenza
Interventions: DRUG: Interferon alfacon-1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Intravenous Triapine (IND # 68338) in Combination With Pelvic Radiation Therapy With or Without Weekly Intravenous Cisplatin Chemotherapy for Locally Advanced Cervical, Vaginal, or Pelvic Gynecologic Malignancies
Status: COMPLETED
Conditions: Recurrent Cervical Cancer|Recurrent Ovarian Epithelial Cancer|Recurrent Vaginal Cancer|Recurrent Vulvar Cancer|Stage III Vaginal Cancer|Stage IIIA Cervical Cancer|Stage IIIA Ovarian Epithelial Cancer|Stage IIIA Vulvar Cancer|Stage IIIB Cervical Cancer|Stage IIIB Ovarian Epithelial Cancer|Stage IIIB Vulvar Cancer|Stage IIIC Ovarian Epithelial Cancer|Stage IIIC Vulvar Cancer|Stage IV Ovarian Epithelial Cancer|Stage IVA Cervical Cancer|Stage IVA Vaginal Cancer|Stage IVB Cervical Cancer|Stage IVB Vaginal Cancer
Interventions: DRUG: triapine|OTHER: laboratory biomarker analysis|RADIATION: external beam radiation therapy|RADIATION: brachytherapy|DRUG: cisplatin|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PECS Block: Plasma Bupivacaine Level
Status: COMPLETED
Conditions: Nerve Blocks
Interventions: PROCEDURE: Unilateral PECS I and II block|PROCEDURE: Bilateral PECS I and II block|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dose-finding Adaptive Phase I/IIa Study to Assess Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of IPP-204106N on Advanced Solid Tumors
Status: COMPLETED
Conditions: All Solid Tumors
Interventions: DRUG: Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Intra-Canal Cryotherapy on Post-Endodontic Pain and Interleukin-6 Expression Using Different Irrigation Protocols: A Randomized Clinical Trial
Status: COMPLETED
Conditions: Symptomatic Periapical Periodontitis
Interventions: OTHER: Cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EndoMAXX Endoluminal Valve Technology (EVT) Compared to EndoMAXX
Status: COMPLETED
Conditions: Malignant Esophageal Strictures
Interventions: DEVICE: EndoMAXX Endoluminal Valve Technology (EVT)|DEVICE: EndoMAXX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Polysomnography Study of GSK1838262 Extended Release Tablets Versus Placebo in RLS and Associated Sleep Disturbance
Status: COMPLETED
Conditions: Restless Legs Syndrome|Restless Legs Syndrome (RLS)
Interventions: DRUG: GSK1838262 Extended Release Tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Team Based Psychosocial Care to Promote, Maintain and Restore Wellness of Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Standard of Care Distressed in study Arm Distressed|BEHAVIORAL: Psycho-Education|BEHAVIORAL: Team Based Care|BEHAVIORAL: Standard of Care Non-Distressed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of LigaSure to Conventional Electrocoagulation in Video-assisted Thoracoscopic Surgery Lobectomy
Status: COMPLETED
Conditions: Lung Cancer|Complication of Surgical Procedure
Interventions: DEVICE: LigaSure™|DEVICE: Monopolar electrocautery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Icotinib Following Chemotherapy Versus Chemotherapy as Adjuvant Therapy in Stage IIA-IIIA NSCLC With EGFR Mutation
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DRUG: 6-month Icotinib|DRUG: 12-month icotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test How Well Different Doses of BI 1584862 Are Tolerated by Healthy Men
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1584862|DRUG: Placebo matching BI 1584862|DRUG: midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Dietary Protein on the Regulation of Exosome microRNA Expression in Patients With Insulin Resistance.
Status: RECRUITING
Conditions: Insulin Resistance
Interventions: OTHER: Vegetal protein|OTHER: Animal protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Dietary Supplement Anatabloc in Thyroid Health-ASAP (Antabloc Supplementation Autoimmune Prevention)
Status: COMPLETED
Conditions: Thyroiditis, Autoimmune
Interventions: DIETARY_SUPPLEMENT: Anatabloc Supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dalbavancin Versus Standard Antibiotic Therapy for Catheter-related Bloodstream Infections Due to Staphylococcus Aureus
Status: RECRUITING
Conditions: Catheter Bacteremia|Staphylococcus Aureus Infection
Interventions: DRUG: Dalbavancin administration|DRUG: Standard antibiotic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Investigate the Reliability of Fetal Heart Rate and Maternal Heart Rate Signals Extracted From Biopotential Data
Status: COMPLETED
Conditions: Pregnancy Related
Interventions: DEVICE: Biopotentials measurement with gtec device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vitamin D Substitution for Patients With Chronic Pancreatitis and Malabsorption
Status: COMPLETED
Conditions: Chronic Pancreatitis|Malabsorption Syndromes
Interventions: DRUG: Calcium, Dietary|DRUG: Cholecalciferol|RADIATION: UVB|RADIATION: UV-filtered light.|DRUG: Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation of a Diagnostic Workflow for Personalized Diagnosis of Nephrotic Syndrome
Status: RECRUITING
Conditions: Nephrotic Syndrome
Interventions: DIAGNOSTIC_TEST: Anti-nephrin antibodies|DIAGNOSTIC_TEST: u-RPC cultures
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of ETC-1002 in Participants With Hypercholesterolemia and Hypertension
Status: COMPLETED
Conditions: Hypercholesterolemia|Hypertension
Interventions: DRUG: ETC-1002|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-Blind Trial of Erlotinib/Pazopanib or Erlotinib/Placebo in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Pazopanib|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Mesh Nebulizer and Compressor Nebulizer With Pulmonary Function Test in Pediatric Asthma Attacks
Status: COMPLETED
Conditions: Asthma|Asthma in Children
Interventions: DEVICE: Group 1|DEVICE: Group 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ceramic On Ceramic (COC) 36mm PAS IDE Rollover Subjects; Ceramic Acetabular Bearing With Ceramic Femoral Head in Total Hip Replacement
Status: COMPLETED
Conditions: Non-inflammatory Degenerative Joint Disease|Osteoarthritis|Avascular Necrosis|Post-Traumatic Osteoarthritis of Hip
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Management of Pes Planovalgus With Talocalcaneal Coalition ,Osteotomy vs Arthroereisis
Status: COMPLETED
Conditions: Talocalcaneal Bar|Pes Planus
Interventions: PROCEDURE: Coaltion excision and arthroereisis|PROCEDURE: Coalition excision and corrective osteotomies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Determinants of Vasospasm and Delayed Ischemic Deficits in Aneurysmal Subarachnoid Hemorrhage
Status: COMPLETED
Conditions: Ischemia
Interventions: PROCEDURE: CerebroSpinal fluid and plasma samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate Safety, Efficacy of PBI-4050 & Its Effect on Relevant Biomarkers in T2DM Patients With Metabolic Syndrome
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus|Metabolic Syndrome
Interventions: DRUG: PBI-4050|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Empiric Anti-Mycobacterium Tuberculosis Therapy for Sepsis in Sub-Saharan Africa
Status: RECRUITING
Conditions: Tuberculosis|HIV I Infection|Sepsis
Interventions: OTHER: Immediate anti-TB therapy|OTHER: Sepsis-specific dose anti-TB therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effects of a High-Fat Meal on Bexagliflozin in Healthy Subjects
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Bexagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Comparison of Pull-PEG and Pull-PEG With Gastropexy
Status: COMPLETED
Conditions: Peristomal Infection Rate|Postinterventional Bleeding|Postinterventional Mortality Rate
Interventions: PROCEDURE: Pull-PEG with Gastropexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Antiviral Activity of GS-9669 in Subjects With Chronic Hepatitis C Virus Infection
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: GS-9669 tablets|DRUG: Placebo to Match GS-9669 tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study on Oral Vitamin D Megadoses
Status: COMPLETED
Conditions: Hypovitaminosis D
Interventions: DIETARY_SUPPLEMENT: vitamin D3 (cholecalciferol)|OTHER: olive oil|DIETARY_SUPPLEMENT: calcium carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study Extension of Iloprost Power 15 in Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: iloprost|DRUG: iloprost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Local Oestrogen Versus Placebo as Preoperative Treatment in Patients With Severe Hypospadias: Effects on Post-operative Complications
Status: COMPLETED
Conditions: Hypospadias
Interventions: DRUG: promestriene|DRUG: Placebo|PROCEDURE: Urethroplasty|RADIATION: Wrist X ray|PROCEDURE: Blood test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Proof-of-concept Study Evaluating the Microbiota-gut-brain Axis
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DIAGNOSTIC_TEST: F18-FDG, Tc-99m TRODAT-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Randomized, Open-label, Single Dose, Two-way Crossover Clinical Trial to Compare the Safety, Pharmacokinetic Profiles of UI15AML055MT and Amosartan® Tablet 5/50 mg After a Single Oral Administration in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: UI15AML055MT|DRUG: Amosartan 5/50
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative-dose-response Test (RDR) Adaptation for Chronic Liver Disease
Status: COMPLETED
Conditions: Chronic Liver Disease
Interventions: DIETARY_SUPPLEMENT: retinyl palmitate (UNICEF, Melbourne, Australia)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Qishenyiqi Dripping Pills in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Qishenyiqi dripping pills, 6 bags|DRUG: Qishenyiqi dripping pills, 9 bags|DRUG: Qishenyiqi dripping pills, 12 bags|DRUG: Qishenyiqi dripping pills placebo, 6 bags|DRUG: Qishenyiqi dripping pills placebo, 9 bags|DRUG: Qishenyiqi dripping pills placebo, 12 bags
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinical Trial to Evaluate the Safety and Immunogenicity of the COVID-19 Vaccine
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Two COVID-19 vaccine candidate (TMV-083/V-591) administrations - Low dose|BIOLOGICAL: Two COVID-19 vaccine candidate (TMV-083/V-591) administrations - High dose|BIOLOGICAL: One COVID-19 vaccine candidate (TMV-083/V-591) administration - High dose|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fulvestrant Versus Capecitabine as Maintenance Therapy After First-line Chemotherapy in Patients With HR+/HER2- Metastatic Breast Cancer
Status: RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Fulvestrant|DRUG: Capecitabine Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-FIBRe Study: Predeterminants of Fibre Induced Bloating Response.
Status: COMPLETED
Conditions: Functional Bloating (Disorder)
Interventions: DIETARY_SUPPLEMENT: Fibre 1|DIETARY_SUPPLEMENT: Fibre 2|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Continuous Venovenous Haemofiltration on Organ Failure During the Early Phase of Severe Sepsis
Status: COMPLETED
Conditions: Bacteremia|Gram-Negative Bacterial Infections|Gram-Positive Bacterial Infections|Pneumonia, Bacterial|Shock, Septic|Sepsis
Interventions: PROCEDURE: venovenous hemofiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Medical Results of Testicular Sperm Extraction by Conventional Surgery and Microsurgical Track
Status: TERMINATED
Conditions: Azoospermia
Interventions: PROCEDURE: conventional TESE|PROCEDURE: Micro TESE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Effect of Dapagliflozin on Blood Glucose Level and Renal Safety in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Dapagliflozin 10 mg|DRUG: Matching Placebo for Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Early High-dose Epoetin Alfa During Cardiac Arrest (Pilot Study)
Status: COMPLETED
Conditions: Resuscitation|Cardiopulmonary|Cardiac Arrest
Interventions: DRUG: Epo-alpha
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing a Smartphone Application for Individuals With Eating Disorders
Status: COMPLETED
Conditions: Eating Disorders|Binge Eating Disorder|Bulimia Nervosa
Interventions: BEHAVIORAL: Recovery Record adaptive smartphone application|BEHAVIORAL: Recovery Record standard smartphone application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study Assessing the Safety and Immune Response of PPV-06 Vaccine
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: PPV-06 10 μg|DRUG: PPV-06 50 μg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Pressor Effect of Oral Tyramine During Ozanimod Treatment in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: Placebo|DRUG: Rasigiline|DRUG: Phenelzine|DRUG: Ozanimod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Risperidone Treatment in Schizophrenia Patients Who Are Currently Taking Clozapine
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Placebo|DRUG: Risperdal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Pomegranate Extract on Cardiovascular Risk Markers in Overweight Healthy Subjects
Status: COMPLETED
Conditions: Overweight
Interventions: DIETARY_SUPPLEMENT: Pomegranate extract-first dose-Group A|DIETARY_SUPPLEMENT: Placebo-first dose-Group B|DIETARY_SUPPLEMENT: Pomegranate extract-first dose-Group B|DIETARY_SUPPLEMENT: Placebo-first dose-Group A|DIETARY_SUPPLEMENT: Pomegranate extract-second dose-Group A|DIETARY_SUPPLEMENT: Placebo-second dose-Group B|DIETARY_SUPPLEMENT: Pomegranate extract-second dose-Group B|DIETARY_SUPPLEMENT: Placebo-second dose-Group A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immune Response to a Mammaglobin-A DNA Vaccine In Breast Cancer Patients Undergoing Neoadjuvant Endocrine Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Breast Carcinoma|Malignant Neoplasm of Breast
Interventions: BIOLOGICAL: Mammaglobin-A DNA Vaccine|PROCEDURE: Optional biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of LUMIGAN® RC Versus DuoTrav® in Patients Who Require Further Intraocular Pressure (IOP) Reduction
Status: COMPLETED
Conditions: Glaucoma, Open-Angle|Ocular Hypertension
Interventions: DRUG: travoprost ophthalmic solution 0.004%|DRUG: travoprost 0.004% / timolol 0.5% combination ophthalmic solution|DRUG: Bimatoprost ophthalmic solution 0.01%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness And Safety Of Frovatriptan For The Management (Acute Treatment) Of Menstrual Migraine
Status: COMPLETED
Conditions: Menstrual Migraine (MM) Headaches
Interventions: DRUG: Frovatriptan|DRUG: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Pre-Emptive Pudendal Nerve Block for Pelvic Reconstructive Surgery
Status: WITHDRAWN
Conditions: Pelvic Organ Prolapse
Interventions: DRUG: pudendal block|DRUG: no pudendal block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Lithium in Patients With Autism Spectrum Disorder and Phelan-McDermid Syndrome (SHANK3 Haploinsufficiency)
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Lithium Carbonate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant ChemoRadiotherapy Prior to Surgery in Stage IVa Oral Cancers
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of Oral Cavity
Interventions: DRUG: Neoadjuvant chemotherapy|RADIATION: Neoadjuvant radiotherapy|PROCEDURE: Resection and reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Treatment Protocol for the Use of Intravenous Ganciclovir in AIDS Patients With Immediately Sight-Threatening CMV Retinitis
Status: COMPLETED
Conditions: Cytomegalovirus Retinitis|HIV Infections
Interventions: DRUG: Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Immediate Versus Early Oral Hydration On Caesarean Section Post Operative Outcomes
Status: COMPLETED
Conditions: Cesarean Section
Interventions: DIETARY_SUPPLEMENT: Immediate hydration|DIETARY_SUPPLEMENT: Early hydration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Sleep Disturbance in Children With ASD
Status: COMPLETED
Conditions: Physical Exercise|Sleep Disturbance|Autism Spectrum Disorder|Melatonin Deficiency
Interventions: BEHAVIORAL: Jogging program|DRUG: Melatonin supplement intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ALlogeneic Cardiosphere-derived Stem Cells (CDCs) for Pulmonary Hypertension therApy
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension (PAH)
Interventions: BIOLOGICAL: Allogeneic Human Cardiosphere-Derived Stem Cells|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Bispectral Index Monitoring for Midazolam and Meperidine Induced Sedation During Endoscopic Submucosal Dissection
Status: UNKNOWN
Conditions: Gastric Adenoma|Gastric Cancer
Interventions: DEVICE: bispectral index monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Melatonin Application of Immediate Dental Implant
Status: COMPLETED
Conditions: Immediate Dental Implant
Interventions: DEVICE: immediate implant placement|DRUG: Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Randomized Trial of Pre-Operative IMRT+Surgery Versus Surgery Alone For Primary Retroperitoneal Sarcoma
Status: COMPLETED
Conditions: Sarcoma
Interventions: PROCEDURE: Surgical Resection|PROCEDURE: Intensity Modulated Radiation Therapy (IMRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of an Evening PROtein PrEload on Metabolic Health in Night ShIfT Workers (PROPENSITy)
Status: RECRUITING
Conditions: Type 2 Diabetes|Shift-work Disorder
Interventions: DIETARY_SUPPLEMENT: whey protein|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of a Multi-dose Regimen of Mebendazole Against Hookworm in Children
Status: COMPLETED
Conditions: Hookworm
Interventions: DRUG: Treatment with one of the two regimens of mebendazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Versus Propofol Sedation in Flexible Bronchoscopy: A Randomized Controlled Trial
Status: UNKNOWN
Conditions: Sedation Complication
Interventions: DRUG: Dexmedetomidine|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a Sabin Inactivated Poliovirus Vaccine
Status: COMPLETED
Conditions: Polio
Interventions: BIOLOGICAL: sIPV|BIOLOGICAL: Commercialized sIPV|BIOLOGICAL: Commercialized IPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Multi-centre, Comparative, Double Blind, Randomised Cross-over Trial Investigating Single Dose Pharmacokinetics and Safety of Turoctocog Alfa Pegol From the Pivotal Process and Turoctocog Alfa Pegol From the Commercial Process in Patients With Severe Haemophilia A
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A
Interventions: DRUG: turoctocog alfa pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Capecitabine in Treatment of Elderly Patients With Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer|Metastasis
Interventions: DRUG: Capecitabine and Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Silibinin(A) as a Potential Anti-obesity Agent
Status: ACTIVE_NOT_RECRUITING
Conditions: Overweight and Obesity|Hypercholesterolemia|Hypertriglyceridemia
Interventions: DIETARY_SUPPLEMENT: Silibinin A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature
Status: RECRUITING
Conditions: Anxiety Disorders and Symptoms|Fibromyalgia|Arthritis|Chronic Pain|Hypertension,Essential
Interventions: DIETARY_SUPPLEMENT: IV Vitamin Infused Therapy Treatment|DRUG: Herbal medicine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Negative Pressure Wound Therapy Registry
Status: UNKNOWN
Conditions: Diabetic Foot Ulcers|Venous Stasis Ulcer|Pressure Ulcer|Surgical Wound Dehiscence|Burns|Other Types of Chronic Non Healing Wounds
Interventions: DEVICE: NPWT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Activity and Safety of Oral Selinexor in Participants With Severe COVID-19 Infection
Status: COMPLETED
Conditions: Coronavirus Infection
Interventions: DRUG: Selinexor|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Surgical Treatment of Intra-spinal Canal Tumors Via Trans-Quadrant Channel
Status: UNKNOWN
Conditions: Spinal Neoplasms
Interventions: PROCEDURE: Trans-Quadrant Channel Surgery|PROCEDURE: Conventional Open Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of an Anti-gravity Treadmill on Functional Outcome in Non-operatively Treated Pelvic Fractures - a Pilot Study
Status: COMPLETED
Conditions: Weight-bearing|Rehabilitation
Interventions: DEVICE: anti-gravity treadmill
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib in Patients With Metastatic Castration-Resistant Prostate Cancer With PTEN Deletion
Status: RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept of Hybrid Robotics for Gait Rehabilitation of Persons Post-stroke
Status: NOT_YET_RECRUITING
Conditions: Stroke Sequelae|Gait, Hemiplegic
Interventions: DEVICE: Combined overground gait exoskeleton and FES applied to lower limb|DEVICE: Overground gait exoskeleton
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Video Assisted Ablation of Pilonidal Sinus Versus Conventional Treatment
Status: COMPLETED
Conditions: Chronic Sacrococcygeal Pilonidal Sinus
Interventions: PROCEDURE: Video assisted ablation of pilonidal sinus|PROCEDURE: Bascom Cleft lift procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repetitive Trans-cranial Magnetic Stimulation of the Motor Cortex in Fibromyalgia: A Study Evaluating the Clinical Efficiency and the Metabolic Correlate in 18FDG-PET
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: OTHER: Transcranial stimulation|OTHER: Transcranial stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bi-weekly Temozolomide Plus Bevacizumab for Adult Patients With Recurrent Glioblastoma Multiforme
Status: COMPLETED
Conditions: Recurrent Glioblastoma Multiforme|Recurrent Gliosarcoma
Interventions: DRUG: temozolomide and bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Ease of I-gel Insertion With Two Different Techniques in Adults
Status: COMPLETED
Conditions: Airway Morbidity
Interventions: DEVICE: Supraglottic airway device (I-gel) insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy and Safety of Chloroprocaine 1% and 2% in Pediatric Population
Status: RECRUITING
Conditions: Hernia, Inguinal|Flat Foot
Interventions: DRUG: Chloroprocaine 1% Injectable Solution|DRUG: Chloroprocaine 2% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Circumferential Pulmonary Vein Isolation and Complex Pulmonary Vein Isolation Additional Linear Ablation for Recurred Atrial Fibrillation After Previous Catheter Ablation: Prospective Randomized Trial (RILI Trial)
Status: COMPLETED
Conditions: Recurred Atrial Fibrillation
Interventions: PROCEDURE: Procedure with circumferential pulmonary vein isolation|PROCEDURE: Procedure with linear ablation in addiction to pulmonary vein isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 2%-Mepivacaine With Two Different Vasoconstrictors Solutions in Third Molar Surgery a Comparative Study
Status: UNKNOWN
Conditions: Pain|Trismus|Edema
Interventions: DRUG: mepivacaine chloridrato epinephrine|DRUG: mepivacaine chloridrato levonordefrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TheraSphere Post-Approval Study to Calculate the Radiation-absorbed Dose of Tc-99m MAA.
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DEVICE: Technetium-99m macroaggregated albumin (Tc-99m MAA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tislelizumab+Lenvatinib+Gemox Regiment for Potentially Resectable Locally Advanced Malignant Tumors of Biliary System.
Status: UNKNOWN
Conditions: Potentially Resectable Locally Advanced Malignant Tumors of Biliary System
Interventions: DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Progressive Relaxation Exercises on Bariatric Surgery Period
Status: ENROLLING_BY_INVITATION
Conditions: Obesity, Morbid|Bariatric Surgery Candidate|Anxiety|Postoperative Pain
Interventions: BEHAVIORAL: Progressive relaxation exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of a High-intensity Progressive-cycle Program on Quality of Life and Motor Symptomatology in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease|Exercise|Physical Activity|Quality of Life
Interventions: OTHER: Balance|OTHER: Endurance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IPV in Moderate to Severe Chronic Malnourished 9-12 Month Old Children in Karachi.
Status: COMPLETED
Conditions: Immunity to Polio Vaccines in Malnourished Infants|Immunity to Polio Vaccines in Non-malnourished Infants
Interventions: BIOLOGICAL: Injectable polio vaccine and Bivalent oral polio vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 18F-fluorodeoxyglucose (18F-FDG) Positron Emission Tomography in Oncology
Status: COMPLETED
Conditions: Brain Neoplasms|Lung Neoplasms|Lymphoma|Melanoma|Colorectal Neoplasms
Interventions: PROCEDURE: Positron Emission Tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase II Study of Toripalimab Plus Stereotactic Body Radiotherapy in Colorectal Cancer Patients With Oligometastasis
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Toripalimab|RADIATION: Stereotactic Body Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strategies to Prevent Pneumonia (SToP Pneumonia)
Status: COMPLETED
Conditions: Ventilator Associated Pneumonia
Interventions: PROCEDURE: Toothbrushing only|PROCEDURE: Chlorhexidine only|PROCEDURE: Toothbrushing and Chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Spray Diathermy Versus Harmonic Scalpel Technique for Hepatic Parenchymal Transection
Status: COMPLETED
Conditions: End Stage Liver Disease
Interventions: DEVICE: harmonic scalpel|DEVICE: spray mode diathermy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AP5346 or Oxaliplatin in Treating Patients With Metastatic and/or Unresectable Recurrent Head and Neck Cancer
Status: UNKNOWN
Conditions: Head and Neck Cancer
Interventions: DRUG: DACH polymer platinate AP5346|DRUG: oxaliplatin|GENETIC: gene expression analysis|OTHER: immunohistochemistry staining method|OTHER: pharmacological study|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Accelerated Partial Breast Radiation Therapy Using High-Dose Rate Brachytherapy in Treating Patients With Early Stage Breast Cancer After Surgery
Status: COMPLETED
Conditions: Ductal Breast Carcinoma In Situ|Estrogen Receptor Positive|Invasive Breast Carcinoma|Progesterone Receptor Positive|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage IIA Breast Cancer
Interventions: RADIATION: Accelerated Partial Breast Irradiation|RADIATION: High-Dose Rate Brachytherapy|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibrutinib Combined With Gemcitabine and Nab-Paclitaxel in Patients With Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: Ibrutinib|DRUG: Paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long-Term Study of JNS007ER in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Paliperidone extended-release (JNS007ER)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antimalarial Drug Resistance in Mali
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: chloroquine|DRUG: sulfadoxine-pyrimethamine|DRUG: amodiaquine|DRUG: amodiaquine+artesunate|DRUG: amodiaquine+sulfadoxine-pyrimethamine|DRUG: sulfadoxine-pyrimethamine+artesunate|DRUG: artemether-lumefantrine|DRUG: mefloquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation (tDCS) on Working Memory in College Going Students
Status: NOT_YET_RECRUITING
Conditions: Working Memory Deficits
Interventions: DEVICE: Transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Alcohol Misuse, Gut Microbial Dysbiosis and PrEP Care Continuum: Application and Efficacy of SBIRT Intervention
Status: RECRUITING
Conditions: Alcohol Use Disorder|Risk Behavior, Health|Dysbiosis|HIV Infections
Interventions: BEHAVIORAL: Screening, Brief Intervention, Referral to Treatment (SBIRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dysport in Hallux Abducto Valgus (HAV) Phase IIa
Status: COMPLETED
Conditions: Hallux Abducto Valgus
Interventions: BIOLOGICAL: Botulinum toxin type A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tg01 Vaccine / Qs-21 Stimulon™ With Or Without Balstilimab As Maintenance Therapy Following Adjuvant Chemotherapy In Patients With Resected Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreas Cancer
Interventions: BIOLOGICAL: TG01 Vaccine|DRUG: QS-21|DRUG: Balstilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Overweight Induced by Antipsychotic Medication in Young People With Autism Spectrum Disorders (ASD)
Status: COMPLETED
Conditions: Overweight|Autism Spectrum Disorder
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Brexpiprazole as Adjunctive Therapy in the Treatment of Major Depressive Disorder
Status: TERMINATED
Conditions: Major Depressive Disorder
Interventions: DRUG: Brexpiprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inhaled NO in IPF and COPD During 6 Minute Walk Test
Status: UNKNOWN
Conditions: COPD|IPF|Inhaled Nitric Oxide|Six Minute Walk Test|Oxygen Saturation
Interventions: DRUG: Inhaled nitric oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Thyrotropin Level on Iodine Uptake in Metastatic Differentiated Thyroid Cancer
Status: UNKNOWN
Conditions: Differentiated Thyroid Cancer
Interventions: DIAGNOSTIC_TEST: 124I PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Repetitive Arm Training + FES on Upper Extremity Motor Recovery in Sub-acute Stroke Survivors
Status: COMPLETED
Conditions: Stroke|Arm Motor Recovery
Interventions: OTHER: conventional therapy|DEVICE: arm training combined with FES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase IIB 2-Period Crossover Polysomnography Study in Participants With Primary Insomnia (MK-4305-006)
Status: COMPLETED
Conditions: Primary Insomnia
Interventions: DRUG: Suvorexant|DRUG: Dose-matched Placebo to Suvorexant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Secukinumab for Treatment of Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Secukinumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Study of Recommendation System DiaCompanion for Women With Gestational Diabetes Mellitus
Status: RECRUITING
Conditions: Gestational Diabetes Mellitus (GDM)
Interventions: DEVICE: mobile app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigation of the Effectiveness of Core Stabilization Training in Patients With Subacromial Impingement Syndrome
Status: RECRUITING
Conditions: Subacromial Impingement Syndrome
Interventions: OTHER: Core stabilization training|OTHER: Standart Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Gastric Insufflation With the Classic Igel Laryngeal Mask and the New Igelplus Laryngeal Mask Using Gastric Ultrasound
Status: NOT_YET_RECRUITING
Conditions: Surgery|Anesthesia
Interventions: DEVICE: Igelplus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of the Effectiveness of Sitaxsentan Sodium in Patients With Diastolic Heart Failure
Status: COMPLETED
Conditions: Diastolic Heart Failure
Interventions: DRUG: Sitexsentin sodium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of SCTC21C in Participants With CD38+ Hematologic Malignancies
Status: RECRUITING
Conditions: Relapsed or Refractory Hematologic Malignancies
Interventions: BIOLOGICAL: SCTC21C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study for the Application of Cytosorb® in Critically Ill Patients
Status: COMPLETED
Conditions: Rhabdomyolysis|Acute Liver Injury|Cytokine Storm
Interventions: DEVICE: Cytosorb therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mesalazine With Hydrocortisone Sodium Succinate Enema for 4-Week Treatment in Patients With Ulcerative Colitis
Status: UNKNOWN
Conditions: Ulcerative Colitis, Unspecified
Interventions: DRUG: Mesalazine|DRUG: hydrocortisone sodium succinate|DRUG: Mesalazine with hydrocortisone sodium succinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: IMT in Ventilatory Muscle Metaboreflex in COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Inspiratory Muscle Training|OTHER: SHAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Lidocaine Infusion for Postoperative Pain Management in Obese Patients
Status: COMPLETED
Conditions: Bariatric Surgical Pain
Interventions: DRUG: Lidocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION