pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluation in 15 Participants of Blood Flow, Comfort and Efficiency, Using 1 vs 36 Hz Stimulation Via Textile Electrodes
Status: COMPLETED
Conditions: Hemodynamic Instability|Pain
Interventions: DEVICE: Chattanooga Physio, DJO, neuromuscular electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Integrative Medicine of IgA Nephropathy
Status: UNKNOWN
Conditions: Primary IgA Nephropathy
Interventions: DRUG: WM (Shentong Granules)|DRUG: Hormone (prednisone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Value of MRCP+ And Liver Multiscan in the Management of Dominant Strictures in Primary Sclerosing Cholangitis
Status: UNKNOWN
Conditions: PSC|MRI
Interventions: DIAGNOSTIC_TEST: Liver Multiscan sequences baseline|DEVICE: MRCP+ analysis baseline|DEVICE: Liver Multiscan analysis baseline|DIAGNOSTIC_TEST: MRI liver with MRCP|DIAGNOSTIC_TEST: Liver Multiscan sequences follow-up|DEVICE: MRCP+ analysis follow up|DEVICE: Liver Multiscan analysis follow up
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study Assessing KB707 for the Treatment of Locally Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Cancer|Melanoma Stage III|Melanoma Stage IV|Cutaneous Melanoma|Osteosarcoma|Carcinoma, Squamous Cell|Carcinoma, Basal Cell
Interventions: BIOLOGICAL: KB707
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-Blind Trial of Ketamine Therapy Plus or Minus Naltrexone in Treatment Resistant Depression (TRD)
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Milademetan in Advanced/Metastatic Solid Tumors
Status: TERMINATED
Conditions: Solid Tumors|Head and Neck Carcinoma|Cholangiocarcinoma|Sarcoma|Lung Adenocarcinoma|Bladder Urothelial Carcinoma|Stomach Adenocarcinoma|Breast Cancer Invasive|Ovarian Carcinoma|Cervical Cancer|Non Small Cell Lung Cancer|Gastric Cancer|Biliary Tract Cancer|Melanoma|Pancreas Cancer|MDM2 Gene Amplification|Testicular Germ Cell Tumor|Adrenocortical Carcinoma
Interventions: DRUG: RAIN-32
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-63733657 in Healthy Subjects and Subjects With Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: JNJ-63733657|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Compare the Efficacy and Safety of 2 Different Batches of Subcutaneous Dasiglucagon in Patients With T1DM
Status: COMPLETED
Conditions: Hypoglycemia|Diabetes Mellitus, Type 1
Interventions: DRUG: dasiglucagon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prenatal Testing: Amniocentesis Versus Transabdominal Chorionic Villus Sampling (TA CVS)
Status: COMPLETED
Conditions: Pregnancy
Interventions: PROCEDURE: Amniocentesis|PROCEDURE: Transabdominal chorionic villus sampling (TA CVS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Michigan Food and Atopic Dermatitis (M-FAD) Program - Molecular Analytics Project
Status: RECRUITING
Conditions: Atopic Dermatitis|Food Allergy|Healthy
Interventions: OTHER: Data and biospecimen collection|OTHER: Skin biopsies|OTHER: Oral Food Challenge (OFC) procedures
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of the MUC1 Peptide-Poly-ICLC Adjuvant Vaccine in Individuals With Advanced Colorectal Adenoma
Status: COMPLETED
Conditions: Risk for Colorectal Cancer
Interventions: BIOLOGICAL: MUC1 - Poly ICLC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: E7070, Idarubicin and Cytarabine in Relapsed AML and High-Risk Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: E7070|DRUG: Idarubicin|DRUG: Cytarabine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multiple Ascending Dose Study of RO4998452 in Patients With Type 2 Diabetes Mellitus.
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: RO4998452|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ODSH + ICE Chemotherapy in Pediatric Solid Tumors
Status: TERMINATED
Conditions: Recurrent Solid Tumor|Refractory Solid Tumor|Sarcoma|Wilms' Tumor|Neuroblastoma
Interventions: DRUG: ODSH
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Demonstrate Equivalence in Analgesic Efficacy & Bowel Function Between OXN PR Higher Dose & Lower Dose Tablet Strengths in Subjects With Non-cancer or Cancer Pain
Status: COMPLETED
Conditions: Malignant Pain|Non-malignant Pain
Interventions: DRUG: Oxycodone|DRUG: Naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Assessing Cooled Radiofrequency Denervation as a Treatment for Sacroiliac Joint Pain Using the Sinergy System
Status: COMPLETED
Conditions: Other Acute Pain|Chronic Pain
Interventions: DEVICE: Sinergy|DEVICE: Placebo sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Prospective, Randomized Trial of Adjuvant Chemotherapy for Early-Stage Cervical Cancer Patients
Status: COMPLETED
Conditions: Uterine Cervical Neoplasms|Cervical Cancer|Uterine Cervical Cancer
Interventions: PROCEDURE: radical hysterectomy + pelvic lymph node dissection|DRUG: Paclitaxel|DRUG: Cisplatin|DRUG: Cisplatin|RADIATION: Pelvic RT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Optune (NovoTTF-100A) for Recurrent Atypical and Anaplastic Meningioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Brain Cancer
Interventions: DEVICE: Optune (NovoTTF-100A)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ASIS for Enbrel in Plaque Psoriasis
Status: UNKNOWN
Conditions: Plaque Psoriasis.
Interventions: DRUG: Gadolinium|DRUG: Gadolinium|DRUG: Gadolinium|DRUG: Efficacy of Enbrel subcutaneously at Week 12|DRUG: Efficacy of Enbrel subcutaneously at Week 24|DRUG: Efficacy of Enbrel subcutaneously at Week 36|DRUG: Efficacy of Enbrel subdermally at Week 12|DRUG: Efficacy of Enbrel subdermally at Week 24|DRUG: Efficacy of Enbrel subdermally at Week 36|DRUG: PASI 75 n(%) subcutaneously at Week 12|DRUG: PASI 75 n(%) subcutaneously at Week 24|DRUG: PASI 75 n(%) subcutaneously at Week 36|DRUG: PASI 75 n(%) subdermally at Week 12|DRUG: PASI 75 n(%) subdermally at Week 24|DRUG: PASI 75 n(%) subdermally at Week 36|DRUG: Adverse Reactions of Enbrel subcutaneously|DRUG: Adverse Reactions of Enbrel subdermally at Week 36|DRUG: Gadolinium|DRUG: Gadolinium|DRUG: Gadolinium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proparacaine vs Placebo for Corneal Injuries
Status: COMPLETED
Conditions: Corneal Abrasions
Interventions: DRUG: Proparacaine drops 0.05%|DRUG: saline drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Occipital Nerve Stimulation in Intractable Occipital Neuralgias
Status: TERMINATED
Conditions: Occipital Neuralgia
Interventions: DEVICE: Occipital nerve stimulation|OTHER: Optimal Medical Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Live Classical Music and the Response to the Disease and Its Evolution in Patients With Chronic Renal Failure
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Haemodialysis
Interventions: OTHER: Listening to live classical music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Registry of Patients Living With Type 1 Diabetes
Status: RECRUITING
Conditions: Type 1 Diabetes Mellitus
Interventions: OTHER: Online questionnaire - Phase 1|OTHER: Online questionnaire - Phase 2|OTHER: Online questionnaire - Phase 3|OTHER: Food questionnaire|OTHER: Pedometer|OTHER: Waist circumference|OTHER: Blood and urine tests|OTHER: List of medications|OTHER: Continuous glucose monitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: LCI-NOS-PAIN-001: A Prospective, Pharmacogenomic-Driven Study of Pain Management in Oncology Outpatients
Status: TERMINATED
Conditions: Malignant Tumor of Ill-defined Site
Interventions: GENETIC: Pharmacogenomic Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Image-Guided (68Ga-PSMA-11 PET/CT) Prostate Biopsy for the Diagnosis of Prostate Cancer in Men With Prior Negative/Inconclusive Biopsy
Status: RECRUITING
Conditions: Prostate Carcinoma
Interventions: PROCEDURE: Biopsy of Prostate|OTHER: Gallium Ga 68 Gozetotide|PROCEDURE: Transrectal Ultrasonography Guided Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Entecavir/Pegylated Interferon in Immune Tolerant Children With Chronic Hepatitis B Virus (HBV) Infection
Status: COMPLETED
Conditions: Hepatitis B
Interventions: DRUG: Entecavir and peginterferon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Complete Denture Tooth Movement in Digital Light Processing Versus Conventional Fabrication Techniques
Status: UNKNOWN
Conditions: Rapid Prototyping in Dentures
Interventions: OTHER: Complete Denture|OTHER: Rapid prototyped denture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Treatment of Chronic Medium-severe Periodontitis With Mesenchymal Stem Cells Predifferentiated in Osteogenic Direction
Status: COMPLETED
Conditions: Periodontitis, Chronic
Interventions: BIOLOGICAL: mesenchymal stem cells|OTHER: standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Extra- Fine Versus Coarse-Particle Inhaled Corticosteroids (ICS) on Ventilation Heterogeneity in Children With Poorly Controlled Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: beclomethasone|DRUG: fluticasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-dermal Injections of DLX105 Into Lesional Skin in Patients With Mild-to-moderate Psoriasis Vulgaris
Status: COMPLETED
Conditions: Mild-to-moderate Psoriasis Vulgaris
Interventions: DRUG: DLX105
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ASpirin vs Triflusal for Event Reduction In Atherothrombosis Secondary Prevention (ASTERIAS)
Status: COMPLETED
Conditions: Atherothrombosis
Interventions: DRUG: Aspirin|DRUG: Triflusal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Assessment of Keratinized Gingiva With and Without PRF Application in Patients With Dental Implant
Status: UNKNOWN
Conditions: Thickening; Gingival
Interventions: BIOLOGICAL: platelet rich fibrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Pacemaker With Closed Loop Stimulation Compared to Pacemakers With and Without Standard Rate Response
Status: COMPLETED
Conditions: Bradycardia
Interventions: DEVICE: Closed Loop Stimulation (CLS)|DEVICE: Standard Rate Adaptive (R) Technology|DEVICE: Non-rate adaptive (DDD) pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Epilepsy
Status: TERMINATED
Conditions: Epilepsia Partialis Continua|Status Epilepticus
Interventions: PROCEDURE: repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of beta3-adrenoceptor Agonist on Patients With Overactive Bladder and as a Urinary Biomarker
Status: UNKNOWN
Conditions: Overactive Bladder Syndrome|Detrusor Overactivity
Interventions: DRUG: Mirabegron 50 MG|DRUG: Solifenacin Succinate 5 MG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase I Clinical Study of α-PD-L1/DLL3 CAR-T in Patients With R/R SCLC
Status: NOT_YET_RECRUITING
Conditions: Small Cell Lung Cancer Extensive Stage
Interventions: DRUG: α-PD-L1/4-1BB DLL3 CAR-T (BHP01)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quince Seed Jelly and Breast Milk on Nipple Fissures
Status: COMPLETED
Conditions: Primiparity|Postpartum
Interventions: OTHER: Quince seed jelly group|OTHER: Breast milk group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Preventing and Addressing At-obesity-Risk Early Years iNtervention With Home Visits in Toronto (PARENT): A Pragmatic RCT
Status: UNKNOWN
Conditions: Child Obesity
Interventions: BEHAVIORAL: Parenting education program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Virtual Hepatic Venous Pressure Gradient (vHVPG) With CT Angiography (CHESS1601)
Status: COMPLETED
Conditions: Hypertension, Portal
Interventions: PROCEDURE: HVPG measurement|PROCEDURE: CTA|PROCEDURE: Doppler ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Venetoclax + Azacitidine vs. Induction Chemotherapy in AML
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Cytarabine|DRUG: Idarubicin|DRUG: Daunorubicin|DRUG: Liposomal daunorubicin and cytarabine|DRUG: Venetoclax|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of OLR in First-line Treatment of Mantle Cell Lymphoma
Status: UNKNOWN
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Orelabrutinib in in combination of rituximab and lenalidomide(OLR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy
Status: COMPLETED
Conditions: Common Variable Immunodeficiency|X-linked Agammaglobulinemia|Autosomal Recessive Agammaglobulinemia
Interventions: BIOLOGICAL: Human Normal Immunoglobulin for Subcutaneous Administration (IGSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cryotherapy vs. Cryocompression for Preventing Chemotherapy-induced-peripheral-neuropathy in Women Undergoing Chemotherapy
Status: UNKNOWN
Conditions: Chemotherapy-induced Peripheral Neuropathy|Chemotherapeutic Toxicity|Chemotherapeutic Agent Toxicity
Interventions: DEVICE: Hilotherm Chemo Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Teclistamab|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alotinib Plus Durvalumab-Platinum-Etoposide in First-line Treatment Extensive Small-cell Lung Cancer
Status: UNKNOWN
Conditions: SCLC, Extensive Stage
Interventions: DRUG: Alotinib Plus Durvalumab-Platinum-Etoposide in First-line Treatment Extensive Small-cell Lung Cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Bevacizumab for Vitreous Hemorrhage
Status: COMPLETED
Conditions: Diabetic Retinopathy|Vitreous Hemorrhage
Interventions: DRUG: bevacizumab|PROCEDURE: pars plana vitrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-Dose Escalation Study Followed by a Multiple-Dose Escalation Study of SKL24741 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: SKL24741|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Use the Combined Version of ICIQ-SF and Quality of Life Scale in Mixed Urinary Incontinence
Status: NOT_YET_RECRUITING
Conditions: Incontinence, Urge|Incontinence Stress|Quality of Life
Interventions: DIAGNOSTIC_TEST: Combined version of International Consultation on Incontinence Questionnaire Short Form (ICIQ SF) and quality of life scale|DIAGNOSTIC_TEST: Bladder diary|DIAGNOSTIC_TEST: Pad test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transcutaneous Electrical Nerve Stimulation With Frequency Specific Microcurrent Resonance Therapy for Non Specific Chronic Low Back Pain Patents: a Prospective Double Blinded, Randomized, Placebo Control Trial
Status: COMPLETED
Conditions: Non Specific Chronic Low Back Pain
Interventions: DEVICE: Transcutaneous electrical nerve stimulation with frequency-specific microcurrent resonant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NMDA-enhancing Treatment for Cognitive Dysfunction of Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: NMDAE|DRUG: Placebo Cap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: QAX576 in Patients With Pulmonary Fibrosis Secondary to Systemic Sclerosis
Status: TERMINATED
Conditions: Pulmonary Fibrosis Secondary to Systemic Sclerosis
Interventions: DRUG: QAX576|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cetuximab, Chemotherapy, and Radiation Therapy for Operable Stage III or IV Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: Cetuximab|DRUG: Carboplatin|DRUG: Paclitaxel|RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Etoposide Plus Lobaplatin Versus Etoposide Plus Cisplatin for Patients With Limited Small-cell Lung Cancer
Status: UNKNOWN
Conditions: Small-cell Lung Cancer
Interventions: DRUG: etoposide plus lobaplatin|DRUG: etoposide plus cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study of UCART22 in Patients With Relapsed or Refractory CD22+ B-cell Acute Lymphoblastic Leukemia (BALLI-01)
Status: RECRUITING
Conditions: B-cell Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: UCART22|BIOLOGICAL: CLLS52
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Study of Camrelizumab Plus Chemotherapy in Triple Negative Breast Cancer (TNBC)
Status: UNKNOWN
Conditions: Triple Negative Breast Cancer
Interventions: BIOLOGICAL: Camrelizumab|DRUG: Nab paclitaxel|DRUG: Epirubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ⅳ Clinical Trial of the Recombinant Hepatitis E Vaccine (Escherichia Coli)
Status: COMPLETED
Conditions: Hepatitis E
Interventions: BIOLOGICAL: Recombinant Hepatitis E Vaccine (Escherichia Coli)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical and Microbiological Approach in Orthopedic Treatment of Patients When Choosing a Structural Material
Status: RECRUITING
Conditions: Oral Microbiota
Interventions: DIAGNOSTIC_TEST: dental prosthetics, biofilm response and oral microbiota
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CAPOX, Bevacizumab and Trastuzumab for Patients With HER2-Positive Metastatic Esophagogastric Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophageal Cancer|Gastric Cancer
Interventions: DRUG: bevacizumab|DRUG: trastuzumab|DRUG: oxaliplatin|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Feasibility of Using Clinician-directed and Digital Application Supported Cognitive Behavior Therapy (CBT) in Conjunction With Esketamine in Participants With Treatment-resistant Depression
Status: WITHDRAWN
Conditions: Depression
Interventions: DRUG: Esketamine|BEHAVIORAL: Cognitive Behavioral Therapy (CBT)|DRUG: Antidepressant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase I Safety and Immunogenicity of FP-02.2 in Chronic Hepatitis B
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: FP-02.2 Vaccine|OTHER: Placebo|OTHER: IC31® Adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Parallel Study for Simulated Internal Jugular Vein Cannulation Using Simple Needle Guide Device
Status: COMPLETED
Conditions: Doctors Attending a Central Line Insertion Training Courses for New Residents of a University Hospital From March 2017 to June 2017|Physicians Who Had Less Than 10 Ultrasound Guided Internal Jugular Vein Cannulation Participate in This Study
Interventions: DEVICE: UGIJVC with needle guide device|DEVICE: UGIJVC without needle guide device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Self-Collection and Human Papillomavirus (HPV) Testing in Unscreened Women: a Feasibility Study in Brazil
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: BEHAVIORAL: Pap testing|BEHAVIORAL: Self-collection for HPV testing|BEHAVIORAL: Choice
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study to Evaluate Symptoms of Exocrine Pancreatic Insufficiency in Adult Participants With Cystic Fibrosis or Chronic Pancreatitis Treated With Creon
Status: COMPLETED
Conditions: Cystic Fibrosis|Chronic Pancreatitis
Interventions: DRUG: CREON
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study Testing DNA Extracted From Tumour Tissue Biopsy Samples, Using the Therascreen® KRAS RGQ PCR Kit
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DIAGNOSTIC_TEST: therascreen® KRAS RGQ PCR Kit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Home Biofeedback Therapy for Dyssynergic Defecation, Fecal Incontinence and Urinary Incontinence
Status: RECRUITING
Conditions: Fecal Incontinence|Dyssynergic Defecation|Urinary Incontinence
Interventions: OTHER: Home Biofeedback therapy|OTHER: Office biofeedback therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of the Safety and Effectiveness of Levofloxacin Compared to Ticarcillin/Clavulanate Alone or Followed by Amoxicillin/Clavulanate in the Treatment of Complicated Skin Infections
Status: COMPLETED
Conditions: Skin Diseases, Bacterial
Interventions: DRUG: levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of 90-Minute Versus 60-Minute Sessions of Prolonged Exposure for PTSD
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder|Combat Disorder
Interventions: BEHAVIORAL: 60-minute Prolonged Exposure Therapy|BEHAVIORAL: 90-minute Prolonged Exposure Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dipeptidyl Peptidase-4 Inhibition in Psoriasis Patients With Diabetes (DIP): A Randomized Clinical Trial.
Status: COMPLETED
Conditions: Psoriasis|Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin|DRUG: Gliclazide|DRUG: Sitagliptin matched placebo|DRUG: Gliclazide matched placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single-centre Open Label Study to Investigate the Effect of Repeat Doses of SB-649868 on the Pharmacokinetics of Simvastatin and Atorvastatin in Healthy Male Volunteers.
Status: COMPLETED
Conditions: Sleep Disorders
Interventions: DRUG: Atorvastatin|DRUG: Simvastatin|DRUG: SB649868
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Let's K-Talk - HPV Study for Ethnic Koreans
Status: RECRUITING
Conditions: Human Papillomavirus Viruses|Papillomavirus Vaccines
Interventions: OTHER: K-Talk Intervention (Storytelling and K-Bot)|OTHER: Storytelling Intervention|OTHER: K-Bot Intervention|OTHER: Written Information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Temporomandibular Dysfunction in Patients With Tinnitus: Assessment and Treatment
Status: COMPLETED
Conditions: Tinnitus, Subjective
Interventions: OTHER: TMD treatment: physiotherapy and/or occlusal splints
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adolescent Acts of Kindness Intervention
Status: COMPLETED
Conditions: Inflammation|Mental Health Wellness 1
Interventions: BEHAVIORAL: Self-Focused Acts of Kindness Intervention|BEHAVIORAL: Other-Focused Acts of Kindness Intervention|BEHAVIORAL: Daily Reports
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PIEB vs CEI for Labor Analgesia: An MLAC Study
Status: TERMINATED
Conditions: Pregnancy
Interventions: DRUG: Bupivacaine|DRUG: Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Radiofrequency Pallidotomy in the Management of Dystonia
Status: NOT_YET_RECRUITING
Conditions: Dystonia
Interventions: PROCEDURE: Radiofrequency Pallidotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vardenafil Inhaled for Pulmonary Arterial Hypertension PRN Phase 2B Study
Status: RECRUITING
Conditions: Pulmonary Arterial Hypertension
Interventions: COMBINATION_PRODUCT: Drug: RT234 - vardenafil inhalation powder; Device: Axially Oscillating Sphere dry powder inhaler (AOS DPI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Research of CD22-Targeted CAR-T in B Cell Malignancies
Status: UNKNOWN
Conditions: Diffuse Large B Cell Lymphoma|Follicular Lymphoma|Primary Cutaneous Follicle Centre Lymphoma|Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue|Mantle Cell Lymphoma|Plasma Cell Neoplasm|B Cell Lymphoma
Interventions: DRUG: Autologous chimeric antigen receptor T cell transfusing agent targeting CD22
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Dapansutrile Capsules in Heart Failure
Status: COMPLETED
Conditions: Systolic Heart Failure
Interventions: DRUG: dapansutrile capsules|DRUG: Placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemotherapy in Patients With Intermediate Risk Upper and Mid Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Neoplasms Malignant|Rectum Carcinoma|Rectal Cancer
Interventions: DRUG: Capecitabine|DRUG: Oxaliplatin|DRUG: Capecitabine|RADIATION: Radiotherapy|PROCEDURE: Rectal cancer surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cabozantinib as Subsequent Therapy to an Immune Checkpoint Based Therapy in Renal Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Renal Cell Cancer
Interventions: DRUG: Cabometyx
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melanoma Vaccine With Peptides and Leuprolide
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Leuprolide|BIOLOGICAL: GP100: 209-217(210M) Peptide|BIOLOGICAL: MAGE-3 Peptide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Postoperative Difficult-to-Heal Wounds of Clinical Trial Registration
Status: NOT_YET_RECRUITING
Conditions: Wound Heal
Interventions: BEHAVIORAL: Intervention program based on TIME-CDST tool led by wound specialist nurses|BEHAVIORAL: A routine wound care program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gross Myofascial Release in Cervical Radiculopathy Pat
Status: COMPLETED
Conditions: Cervical Radiculopathy
Interventions: OTHER: gross Myofascial Release|OTHER: conventional selected exercise program|DEVICE: Transcutaneous electrical nerve stimulation (TENS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Germanium-Embedded Knee Brace on Patient Recovery After ACL Reconstruction
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament Injuries
Interventions: OTHER: Incrediwear Germanium-Embedded Knee Brace following ACL reconstruction|OTHER: Replica Knee Brace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Self-monitoring of the Intraocular Pressure Versus Hospital-based Diurnal Monitoring
Status: RECRUITING
Conditions: Intraocular Pressure
Interventions: DEVICE: icare HOME device (Icare Oy, Vanda, Finland)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety of and Immune Response to Recombinant Live Attenuated Parainfluenza Type 3 Virus Vaccine in Healthy Infants and Children
Status: COMPLETED
Conditions: Paramyxoviridae Infections|Virus Diseases
Interventions: DRUG: rHPIV3cp45|DRUG: rHPIV3cp45 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Buprenorphine for Treatment of Acute Pain
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: Buprenorphine|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Sugar-free Isotonic Drink on Different Health Bioparameters
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Volunteers
Interventions: OTHER: INTAKE OF ISOTONIC DRINK|OTHER: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Vitis Vinifera Extract on Oxidative Stress, Inflamatory Biomarkers and Hormones in High Trained Subjects
Status: UNKNOWN
Conditions: Athletic Injuries
Interventions: DIETARY_SUPPLEMENT: grape fruit (vitis vinifera) extract in capsule with 205 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tislelizumab With Fruquintinib, Metronidazole, in Mismatch Repair-proficient or Microsatellite Stability, Advanced Colorectal Cancer: a Multicenter, Single Arm, Clinical Trial
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: Tislelizumab with Fruquintinib, Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Training of Resident Surgeons in Single-Port Thoracoscopic Surgery Wound Position Selection
Status: NOT_YET_RECRUITING
Conditions: Surgical Education
Interventions: OTHER: Metaverse system (Patients)|OTHER: Metaverse system (Resident Physician)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Phase II Trial of CyberKnife Radiosurgery to Perioptic Tumors
Status: COMPLETED
Conditions: Tumor, Benign, Optic Nerve
Interventions: RADIATION: CyberKnife Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Automated Insulin Therapy Early Initiated After Diagnosis on Blood Glucose Control in Children and Adolescents With Type 1 Diabetes
Status: RECRUITING
Conditions: Diabetes
Interventions: DEVICE: OmniPod 5|DEVICE: Dexcom G6|OTHER: PAID questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HMPL-689 Drug Interaction Study With CYP3A Inhibitor/CYP2C9 Inhibitor/CYP3A Inducer/PPI
Status: COMPLETED
Conditions: Relapsed or Refractory Lymphoma
Interventions: DRUG: Itraconazole 200 mg|DRUG: Fluconazole 400 mg|DRUG: Rifampin 600 mg|DRUG: Rabeprazole 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Statins in Chronic Hepatitis C Patients Receiving Sofosbuvir/Daclatasvir Combination
Status: COMPLETED
Conditions: Chronic Hepatitis c|Metabolic Syndrome
Interventions: DRUG: Simvastatin 10mg|DRUG: sofosbuvir plus daclatasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Efficacy and Safety of Pitavastatin/Fenofibrate in Complex-dyslipidemia
Status: COMPLETED
Conditions: Complex-dyslipidemia
Interventions: DRUG: HL-PIF cap.160/2mg + Placebo|DRUG: Livalo tab. 2mg + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Arm Study of Acalabrutinib Conbimed With Obinutuzumab in Chinese Patients With Previously Untreated CLL
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Acalabrutinib|DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 68Ga-NY104 PET/CT in Patients With Metastasis/Recurrence Clear Cell Renal Cell Carcinoma Suspicion
Status: RECRUITING
Conditions: Clear Cell Renal Cell Carcinoma
Interventions: DIAGNOSTIC_TEST: 68Ga-NY104 PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Cognitive Behavioural Therapy for Insomnia on Endocrine Therapy Adherence
Status: ACTIVE_NOT_RECRUITING
Conditions: Insomnia|Breast Cancer|Adherence, Medication|Quality of Life|Survivorship
Interventions: BEHAVIORAL: Cognitive behavioural therapy for insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ultrasound Guided TAP Block for Postoperative Analgesia After Abdominal Surgery.
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Bupivacaine 0.25% 20ml on each side Sonar guided TAB|DRUG: Morphine 10mg|DRUG: Morphine 15mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Anti-cytomegalovirus Treatment in the Management of Relapsing Ulcerative Colitis Requiring Vedolizumab Therapy
Status: TERMINATED
Conditions: Ulcerative Colitis, Unspecified
Interventions: DRUG: Valganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of Copanlisib to Usual Treatment (Fulvestrant and Abemaciclib) in Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Breast Carcinoma|Metastatic HER2-Negative Breast Carcinoma|Metastatic Hormone Receptor-Positive Breast Carcinoma|Recurrent Breast Carcinoma
Interventions: DRUG: Abemaciclib|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Copanlisib Hydrochloride|PROCEDURE: Diagnostic Imaging|PROCEDURE: Echocardiography|DRUG: Fulvestrant|PROCEDURE: Multigated Acquisition Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vilastobart (XTX101) Monotherapy and Vilastobart and Atezolizumab Combination Therapy in Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: vilastobart (XTX101)|DRUG: Atezolizumab|DRUG: vilastobart (XTX101)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anlotinib Plus Platinum-etoposide in First-line of Extensive-stage Small-cell Lung Cancer
Status: UNKNOWN
Conditions: Extensive-stage Small-cell Lung Cancer
Interventions: DRUG: Platinum-etoposide+Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Immunogenicity, and Pharmacokinetics of GR2102 in Healthy Adult
Status: RECRUITING
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: GR2102 injection|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ficlatuzumab and Cetuximab in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)
Status: COMPLETED
Conditions: Carcinoma, Squamous Cell of Head and Neck|Squamous Cell Carcinoma of the Head and Neck|Squamous Cell Carcinoma, Head And Neck
Interventions: DRUG: Ficlatuzumab|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Validation of a Smartwatch in Persons With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Comfortable walking velocity (CWV)|BEHAVIORAL: Slow walking velocity (SWV: CWV - 20%)|BEHAVIORAL: Fast walking velocity (FWV: CWV + 20%)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Lamotrigine Pregnancy Registry (LAM05)
Status: COMPLETED
Conditions: Epilepsy|Bipolar Disorder
Interventions: DRUG: Lamotrigine monotherapy|DRUG: Lamotrigine polytherapy including valproate|DRUG: Lamotrigine polytherapy without valproate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating PD-1/PD-L1 in Locally Advanced Rectal Cancer by Quantitative Fluorescence Molecular Endoscopy
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Rectal Carcinoma
Interventions: DRUG: Imfinzi|DRUG: Opdivo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prospective Study to Evaluate Mapleson Circuit With Monitored Anesthesia Care During Endobronchial Ultrasound (EBUS) Bronchoscopy
Status: COMPLETED
Conditions: Adenopathy; Localized|Lung Cancer
Interventions: PROCEDURE: Mapleson circuit and nasal trumpet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY353381 (Arzoxifene) for Patients Who Benefitted From This Drug in Other Oncology Trials and Wished to Continue Treatment
Status: COMPLETED
Conditions: Breast Cancer|Endometrial Cancer|Ovarian Cancer
Interventions: DRUG: arzoxifene
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IGG Using in Laparoscopic Gastrectomy for Locally Advanced Gastric Cancer After Neoadjuvant Chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric Cancer|Lymph Node Metastases
Interventions: DRUG: Indocyanine Green
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Dose of Furosemide to Improve Respiratory Distress in Moderate to Severe Bronchiolitis
Status: COMPLETED
Conditions: Bronchiolitis
Interventions: DRUG: Furosemide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Group Therapies for Reducing HIV-risk Behavior in Women Who Have Survived Childhood Sexual Abuse
Status: COMPLETED
Conditions: Alcoholism|Child Abuse, Sexual|Sexual Abuse|Sexual Behavior|Sexually Transmitted Diseases, Viral
Interventions: BEHAVIORAL: Trauma-focused group therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Blueberries on Bone Turnover
Status: UNKNOWN
Conditions: Osteoporosis, Postmenopausal|Bone Loss, Age-related
Interventions: DIETARY_SUPPLEMENT: Blueberry Baseline|DIETARY_SUPPLEMENT: Blueberry Low|DIETARY_SUPPLEMENT: Blueberry Medium|DIETARY_SUPPLEMENT: Blueberry High
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multi-maintenance Olaparib After Disease Recurrence in Participants With Platinum Sensitive BRCAm High Grade Serous Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Olaparib|DRUG: Cediranib|DRUG: Platinum-based Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Effectiveness of a Pilot Program of Physical Activity to Improve HIV Related Functional Limitations and Disability in Adults Aged 40 and Older From Côte d'Ivoire
Status: RECRUITING
Conditions: HIV Infections
Interventions: PROCEDURE: Quantitative research|BEHAVIORAL: Qualitative survey
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION