pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Helping Hypertension Patients to Interpret Blood Pressure Readings and Motivate Blood Pressure Control
Status: COMPLETED
Conditions: Hypertension
Interventions: OTHER: Communication with basic table|OTHER: Communication with enhanced table|OTHER: Communication with enhanced graph
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety Study of TAK-128 in Treating Subjects With Diabetic Peripheral Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathies
Interventions: DRUG: TAK-128|DRUG: TAK-128|DRUG: TAK-128|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Anti-XA Levels in Post-Cesarean Patients Undergoing Enoxaparin Thromboprophylaxis
Status: COMPLETED
Conditions: Obesity|Obesity, Morbid|Pregnancy|Complications; Cesarean Section|Venous Thromboembolism|Postpartum Deep Phlebothrombosis|Pulmonary Embolism
Interventions: DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: IT Matters: The Erectile Restoration Registry
Status: ENROLLING_BY_INVITATION
Conditions: Erectile Dysfunction
Interventions: DEVICE: Tactra Malleable|DEVICE: Spectra™ Concealable Penile Prothesis|DEVICE: AMS Ambicor™ Inflatable Penile Prosthesis|DEVICE: AMS 700™ Inflatable Penile Prosthesis w/Momentary Squeeze (MS) Pump|DEVICE: AMS 700™ Inflatable Penile Prosthesis w/Tenacio™ Pump
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Targeting Minority Stressors to Improve Eating Disorder Symptoms in Sexual Minority Individuals With Eating Disorders
Status: NOT_YET_RECRUITING
Conditions: Eating Disorders|Sexual Minorities
Interventions: BEHAVIORAL: Promoting Resilience to Improve Disordered Eating
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Narrative Exposure Therapy Intervention on Post-traumatic Stress Dissorder and Personal Recovery in Refugees and Asylum Seekers of Sindiane Programme
Status: COMPLETED
Conditions: Post-traumatic Stress Disorder (PTSD)
Interventions: BEHAVIORAL: Psychotherapy using Narrative Exposure Therapy (NET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effects on Lipoprotein Metabolism From PCSK9 Inhibition Utilizing a Monoclonal Antibody
Status: COMPLETED
Conditions: Primary Hyperlipidemia and Mixed Dyslipidemia
Interventions: BIOLOGICAL: Evolocumab|DRUG: Atorvastatin|DRUG: Placebo to Evolocumab|DRUG: Placebo to Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nutritional Intervention For The Treatment Of Uncomplicated SAM
Status: COMPLETED
Conditions: Child Nutrition Disorders
Interventions: DIETARY_SUPPLEMENT: Nutritional intervention with Ready to use theraputic food (RUTF) and prebiotic GOS (galacto oligosaccharides) in combination|DIETARY_SUPPLEMENT: Ready to use theraputic food (RUTF) and Starch (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab (Avastin) Into the Tumor Resection Cavity in Subjects With Glioblastoma Multiforme at First Recurrence
Status: TERMINATED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Avastin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine vs Midazolam for Intraoperative Sedation
Status: COMPLETED
Conditions: Failed Moderate Sedation During Procedure|Minimally Conscious State
Interventions: DRUG: Dexmedetomidine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enzalutamide With or Without Abiraterone and Prednisone in Treating Patients With Castration-Resistant Metastatic Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Adenocarcinoma of the Prostate|Hormone-resistant Prostate Cancer|Recurrent Prostate Cancer|Stage IV Prostate Cancer
Interventions: DRUG: enzalutamide|DRUG: abiraterone|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Upper Extremity' Viscoelastic Properties and Functionality in Subacute Stroke
Status: RECRUITING
Conditions: Stroke|Stiffness of Right Hand, Not Elsewhere Classified|Muscle Tone Abnormalities|Functional; Bleeding
Interventions: DEVICE: MyotonPRO|OTHER: Box and Block Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Persistence Targeted Smoking Cessation in Serious Mental Illness (SMI)
Status: COMPLETED
Conditions: Tobacco Use|Tobacco Smoking|Tobacco Use Cessation|Tobacco Use Disorder|Schizophrenia|Schizoaffective Disorder
Interventions: BEHAVIORAL: Persistence Targeted Smoking Cessation in SMI (PTSC-S)|DRUG: Nicotine patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Racial and Economic Disparities and Unmet Needs in Patients With Severe Aortic Valvular Disease
Status: UNKNOWN
Conditions: Disparities in Treatment of Aortic Valve Stenosis|Aortic Valve Stenosis
Interventions: OTHER: Patient Questionnaire|OTHER: Provider Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nivolumab for Treatment of Squamous Cell Carcinoma of the Skin
Status: RECRUITING
Conditions: Squamous Cell Carcinoma of the Skin
Interventions: DRUG: Nivolumab|DRUG: Nivolumab plus Relatlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Type I Supracondylar Fractures of the Humerus
Status: TERMINATED
Conditions: Type I Supracondylar Fracture of the Humerus
Interventions: PROCEDURE: Cast|PROCEDURE: Splint|PROCEDURE: Tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study of ZN-d5 for the Treatment of Relapsed or Refractory Light Chain (AL) Amyloidosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Amyloidosis|AL Amyloidosis
Interventions: DRUG: ZN-d5
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Tamsulosin 0.4mg on Clinical Outcomes in Korean Men With Severe Symptomatic Benign Prostatic Hyperplasia (BPH)
Status: UNKNOWN
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: Tamsulosin 0.4mg|DRUG: Tamsulosin 0.2mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy as Induction Therapy in Treating Patients With Stage III Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: docetaxel|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Dynamic Hand Splint Treatment in Spastic Hemiparetic Patients
Status: COMPLETED
Conditions: Stroke|Brain Injuries
Interventions: BEHAVIORAL: Task-oriented training with a dynamic hand splint|BEHAVIORAL: Task-oriented training without a dynamic hand splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) Evaluated as a Fixed Dose Combination Regimen in Participants Switching From an Integrase Inhibitor Who Have Experienced Rapid Weight Gain
Status: COMPLETED
Conditions: HIV-1
Interventions: DRUG: D/C/F/TAF FDC|DRUG: TAF/FTC FDC|DRUG: INI Based Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Pelvic Floor Muscle Training Reduce my Prolapse
Status: COMPLETED
Conditions: Pelvic Organ Prolapse
Interventions: BEHAVIORAL: Pelvic floor muscle training and lifestyle advice|BEHAVIORAL: Lifestyle advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sorafenib Tosylate With or Without Stereotactic Body Radiation Therapy in Treating Patients With Liver Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Adult Primary Hepatocellular Carcinoma|Advanced Adult Primary Liver Cancer|Recurrent Adult Primary Liver Cancer
Interventions: DRUG: Sorafenib|RADIATION: stereotactic body radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transversus Abdominis Plane (TAP) Block in Laparoscopic Gastric-bypass Surgery
Status: COMPLETED
Conditions: Gastric-bypass Surgery|Opioid Consumption|Obesity
Interventions: PROCEDURE: TAP-Block|OTHER: Conventional Managment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers
Status: UNKNOWN
Conditions: Hyperalgesia
Interventions: DRUG: Midazolam|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Temozolomide,Thiotepa and Carboplatin With Autologous Stem Cell Rescue Followed by 13-cis-retinoic Acid in Patients With Recurrent/Refractory Malignant Brain Tumors
Status: COMPLETED
Conditions: Brain Tumors
Interventions: DRUG: temozolomide, thiotepa, carboplatin, 13-cis-retinoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed and Cisplatin in Advanced Urothelial Carcinoma
Status: COMPLETED
Conditions: Urothelial Carcinoma
Interventions: DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Dexamethasone|DRUG: Vitamins
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EUS-guided Fine Needle Aspiration (EUS-FNA) Versus EUS-guided Fine Needle Biopsy (EUS-FNB) for Diagnosis of Subepithelial Tumors
Status: WITHDRAWN
Conditions: Gastrointestinal Subepithelial Tumors
Interventions: PROCEDURE: Device: 22G FNA needle|PROCEDURE: Device: 20G FNB needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: FITMI - First In Treating Male Infertility
Status: RECRUITING
Conditions: Infertility, Male
Interventions: DRUG: Denosumab|DRUG: Sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Vonoprazan in Adults With Helicobacter Pylori
Status: COMPLETED
Conditions: Helicobacter Pylori
Interventions: DRUG: Clarithromycin|DRUG: Amoxicillin|DRUG: Bismuth potassium citrate|DRUG: Esomeprazole|DRUG: Vonoprazan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 7 of 7)
Status: ACTIVE_NOT_RECRUITING
Conditions: Exposure to Man-made Visible Light
Interventions: OTHER: Visible light exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Visual Results of the Acrysof IQ Vivity Toric Extended Vision Intraocular Lens
Status: COMPLETED
Conditions: Cataract|Presbyopia|Corneal Astigmatism
Interventions: DEVICE: Acrysof IQ Vivity Toric Extended Vision Intraocular Lens Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Super-Selective Intraarterial Cerebral Infusion of Cetuximab (Erbitux) for Treatment of Relapsed/Refractory GBM and AA
Status: COMPLETED
Conditions: Glioblastoma Multiforme (GBM)|ANAPLASTIC ASTROCYTOMA (AOA)|GBM|Anaplastic Astrocytoma
Interventions: DRUG: Superselective Intraarterial Cerebral Infusion of Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of GX-I7 in Elderly Patients With Asymptomatic or Mild Symptoms of COVID-19
Status: UNKNOWN
Conditions: Covid19
Interventions: DRUG: GX-I7
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Olfactory and Trigeminal Functions in Patients With Multiple Sclerosis: Case-control Study
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis
Interventions: DIAGNOSTIC_TEST: TDI|DIAGNOSTIC_TEST: Trigeminal Test|DIAGNOSTIC_TEST: Cognitive Evaluation by Montreal Cognitive Assessment|DIAGNOSTIC_TEST: Anxiety and Depression questionnaire|DIAGNOSTIC_TEST: Visual Analogue Scale Ratings|DIAGNOSTIC_TEST: Quality of smell Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of the Effect of Teflon vs Non-Teflon Hand Scalers in the Maintenance of Peri-Implant Tissue
Status: COMPLETED
Conditions: Surface Roughness|Maintenance of Dental Implants|Inflammation
Interventions: PROCEDURE: Types of scalers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison Of A Novel Sling With A Traditional Abduction Sling After Shoulder Surgery
Status: UNKNOWN
Conditions: Rotator Cuff Tears|Osteo Arthritis Shoulders
Interventions: DEVICE: Novel sling|DEVICE: Traditional abduction sling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Pharmacokinetic (PK), Safety and Tolerability of Cabotegravir (CAB) 400 Milligrams Per Milliliter (mg/mL) Formulation in Healthy Adult Participants
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Cabotegravir sodium (Oral Lead In)|DRUG: Cabotegravir 400 mg/mL|DRUG: Cabotegravir 200 mg/mL|DRUG: Topical non-steroidal anti-inflammatory drug|DRUG: Topical steroid|DRUG: Placebo creams/gels|DRUG: Recombinant human hyaluronidase PH20 (rHuPH20)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity in Mild Cognitive Impairment (MCI)
Status: RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: DRUG: Atorvastatin Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Effect of Sub-gingival Irrigation With Ibuprofen 2% Mouthwash in Treatment of Periodontal Diseases.
Status: COMPLETED
Conditions: Periodontitis
Interventions: DRUG: placebo|DRUG: Ibuprofen 2% mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Coenzyme Q10 Supplementation and Development of Preeclampsia
Status: COMPLETED
Conditions: Preeclampsia
Interventions: DIETARY_SUPPLEMENT: Coenzyme Q10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Microclinic Social Induction Pilot Intervention for Diabetes and Obesity Management in Qatar
Status: COMPLETED
Conditions: Diabetes Mellitus, Type II|Overweight and Obesity|Hypertension|Behavioral Lifestyle Change|Social Change
Interventions: BEHAVIORAL: Microclinic Social Induction Diabetes and Obesity Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, Efficacy, and Pharmacokinetics of JBT-101 in Systemic Sclerosis
Status: TERMINATED
Conditions: Diffuse Cutaneous Systemic Sclerosis
Interventions: DRUG: JBT-101|DRUG: Placebo|DRUG: Part B Open-Label Extension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Intratumoural Tigilanol Tiglate in Adult Participants With Stage IIIB to IV M1c Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: tigilanol tiglate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Extended Infusion Meropenem in Adult Cystic Fibrosis Patients
Status: TERMINATED
Conditions: Cystic Fibrosis Pulmonary Exacerbation
Interventions: DRUG: Meropenem Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Stapled Anopexy Versus Closed Haemorrhoidectomy for Haemorrhoids
Status: COMPLETED
Conditions: Hemorrhoids
Interventions: PROCEDURE: Circular stapled anopexy|PROCEDURE: Closed diathermy haemorrhoidectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ALVAC-HIV vCP1452 Alone and Combined With MN rgp120
Status: COMPLETED
Conditions: HIV Infections|HIV Seronegativity
Interventions: BIOLOGICAL: ALVAC(2)120(B,MN)GNP (vCP1452)|BIOLOGICAL: MN rgp120/HIV-1|BIOLOGICAL: ALVAC(2)120(B,MN)GNP (vCP1452) placebo|BIOLOGICAL: MN rgp120/HIV-1 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Recombinant FSH Investigation in the Treatment of Infertility With Assisted Reproductive Technology (ART) (RITA-1)
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Follitropin delta|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "GOLIATH" - General Or Local Anaestesia in Intra Arterial THerapy
Status: COMPLETED
Conditions: Stroke|Anesthesia|Cerebral Revascularization
Interventions: PROCEDURE: Local anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Whole Body Vibration in Subacute Stroke Patients
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: Whole body vibration therapy|OTHER: standing on the vibration platform but no vibration will be applied
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: User Testing of an End of Life Medication Support Intervention for Lay Carers (Palliate).
Status: NOT_YET_RECRUITING
Conditions: End of Life|Support, Family
Interventions: OTHER: Paper Package|OTHER: V1 + Preparation Sheet|OTHER: V2 + Video Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Erector Spinae Plane Block and Serratus Posterior Superior Intercostal Plane Block
Status: RECRUITING
Conditions: Erector Spinae Plane Block|Serratus Posterior Superior Intercostal Plane Block|Acute Pain|Postoperative Pain|Breast Neoplasms
Interventions: PROCEDURE: Erector Spinae Plane Block|PROCEDURE: Serratus Posterior Superior Intercostal Plane Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Bevacizumab Compared With Bevacizumab Alone in Treating Patients With Advanced or Metastatic Colorectal Cancer That Has Been Previously Treated
Status: COMPLETED
Conditions: Adenocarcinoma of the Colon|Adenocarcinoma of the Rectum|Recurrent Colon Cancer|Recurrent Rectal Cancer|Stage III Colon Cancer|Stage III Rectal Cancer|Stage IV Colon Cancer|Stage IV Rectal Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: oxaliplatin|DRUG: leucovorin calcium|DRUG: fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pioglitazone and SGLT2 Inhibitors vs. DPP4 Inhibitors in Patients With Stroke
Status: RECRUITING
Conditions: Diabetes Mellitus|Stroke
Interventions: DRUG: Metformin plus Pioglitazone plus an SGLT2 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-line Metastatic Pancreatic Cancer : FOLFIRINOX +/- LV5FU2 in Maintenance Versus Firgem
Status: COMPLETED
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: FOLFIRINOX|DRUG: LV5FU2|DRUG: FOLFIRI.3|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Response to Irradiation on Prostatic Explants ex Vivo, as a Predictive Factor of the Clinical Response to Irradiation of Prostate Cancers
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: PROCEDURE: prostate biopsies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Randomized Phase IIb Trial of DVC1-0101
Status: ACTIVE_NOT_RECRUITING
Conditions: Intermittent Claudication|Peripheral Arterial Disease
Interventions: DRUG: DVC1-0101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ablation and Cementoplasty for Painful Bone Lesions
Status: UNKNOWN
Conditions: Bone Lesion|Bone Metastases|Spine Metastases
Interventions: PROCEDURE: Ablation and Cementoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Adjusted EPOCH Chemotherapy and Rituximab (CD20+) in Previously Untreated Aggressive Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Diffuse Large B-Cell Lymphoma (DLBCL)|Primary Mediastinal Large B-cell Lymphoma|Burkitt Lymphoma|Anaplastic Large-Cell Lymphoma|Gray Zone Lymphoma
Interventions: DRUG: EPOCH|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sotagliflozin Versus Placebo in Patients With Type 2 Diabetes Mellitus Not Currently Treated With Antidiabetic Therapy
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sotagliflozin (SAR439954)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Two-staged Approach in Positioning Endobronchial Blockers Without Fiberoptic Guidance
Status: COMPLETED
Conditions: One-lung Ventilation
Interventions: DEVICE: two-staged endobronchial blocker insertion|DEVICE: single-staged endobronchial blocker insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Ulipristal Acetate in Female Patients With Moderately or Severely Impaired Renal Function, Compared With Matched Healthy Female Subjects
Status: COMPLETED
Conditions: Renal Function
Interventions: DRUG: Ulipristal acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety Study of Budesonide Novolizer Dry Powder Inhaler 200μg to Treat Chinese Patients With Mild to Moderate Asthma
Status: UNKNOWN
Conditions: Asthma
Interventions: DRUG: Budesonide dry powder inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Trial of the RedDress Wound Care System (RD1) in Management of Texas 1a or 2a Neuropathic Diabetic Foot Ulcers.
Status: COMPLETED
Conditions: Neuropathic Diabetic Ulcer - Foot
Interventions: DEVICE: RedDress Wound Care System (RD1)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intralipid Versus SMOFlipid in HPN Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Short Bowel Syndrome|Intestinal Fistula|Crohn Disease|Intestinal Obstruction
Interventions: DIETARY_SUPPLEMENT: SMOFLipid|DIETARY_SUPPLEMENT: Intralipid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of ALKS 3831 in Adults With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Samidorphan (Low Dose)|DRUG: Samidorphan (Medium Dose)|DRUG: Samidorphan (High Dose)|DRUG: Placebo|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spinal Mobilization With Arm Movement and Positional SNAGS in Cervical Radiculopathy Patients
Status: COMPLETED
Conditions: Radiculopathy, Cervical
Interventions: OTHER: Sustained Natural Apophyseal Glides|OTHER: shoulder Mobilization with arm movement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase IIb Study to Investigate the Efficacy and Tolerability of Cinaciguat (150 µg/h, 100 µg/h, 50 µg/h) Given Intravenously to Subjects With Acute Decompensated Chronic Congestive Heart Failure (ADHF)
Status: TERMINATED
Conditions: Heart Failure|Heart Decompensation
Interventions: DRUG: Cinaciguat (BAY58-2667)|DRUG: Cinaciguat (BAY58-2667)|DRUG: Cinaciguat (BAY58-2667)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Microneedles in Photodynamic Therapy
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DEVICE: Microneedle|DRUG: Aminolevulinic Acid|RADIATION: Blue light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sphenopalatine Ganglion Block in Maxillofacial Surgeries
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Sphenopalatine ganglion block using bupivacaine: xylocaine|PROCEDURE: Sphenopalatine ganglion block using normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Dapivirine/Maraviroc Vaginal Ring
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Dapivirine Vaginal Ring|DRUG: Maraviroc Vaginal Ring|OTHER: Placebo Vaginal Ring|DRUG: Dapivirine-Maraviroc Vaginal Ring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Epstein-Barr Virus (EBV)-Specific T Cells as Therapy for Relapsed/Refractory EBV-positive Lymphomas
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: Autologous AdE1- Latent Membrane Protein CTLs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT: Mako Medial Unicondylar Knee Arthroplasty vs Oxford Unicondylar Knee Arthroplasty
Status: RECRUITING
Conditions: Unicompartmental Knee Replacement|Osteo Arthritis Knee|Surgery
Interventions: DEVICE: Medial knee arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NSAIDs With Morphine-PCA Compared to Epidural Analgesia in Thoracotomy Pain
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Diclofenac|DRUG: parecoxib/ valdecoxib|DEVICE: patient controlled epidural analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic of Lewy Body Dementia by Combining Scintigraphy (SPECT) Using a Specific Transporter and Magnetic Resonance Imaging (MRI)
Status: COMPLETED
Conditions: Lewy Body Dementia
Interventions: PROCEDURE: Single photon emission computed tomography and Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Effectiveness of the "YOLO TOUCH" LLLT for Circumference Reduction of the Waistline
Status: COMPLETED
Conditions: Reduction of the Waist Circumference
Interventions: DEVICE: YOLO TOUCH Low Level Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Whole-Body Vibration Treatment Before Total Knee Arthroplasty
Status: RECRUITING
Conditions: Whole-body Vibration|Arthropathy of Knee|Swelling/ Edema
Interventions: OTHER: Whole body vibration|OTHER: Sham-Whole body vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Doxorubicin HCI Liposome Injection Versus Weekly Docetaxel in Patients First Relapse Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Liposomal Doxorubicin|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Bone and Gum Dimension Changes Around Dental Implants Placed in Different Positions in Bone.
Status: COMPLETED
Conditions: Mouth, Edentulous
Interventions: DEVICE: Ankylos dental endosseous implants-Sub-crestal|DEVICE: Ankylos dental endosseous implants-Epi-crestal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Compare the Efficacy of Nor Adrenaline and Terlipressin vs Step up Terlipressin Therapy in Hepatorenal Syndrome
Status: WITHDRAWN
Conditions: Hepatorenal Syndrome
Interventions: DRUG: nor adrenaline and terlipressin|DRUG: step up terlipressin therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breathlessness Relieved by Employing Medical Air to be Titrated by Hospitalized Patients to Improve Inpatient Experience
Status: RECRUITING
Conditions: Dyspnea
Interventions: DEVICE: PneumoCool|OTHER: Current supportive measures that are used in the hospital for standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Triple Site Ventricular Stimulation for Cardiac Resynchronization Therapy (CRT) Candidates
Status: COMPLETED
Conditions: Heart Failure
Interventions: DEVICE: CRT with triple site ventricular stimulation|DEVICE: Conventional cardiac resynchronization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Homeopathy for Prevention of Atrial Fibrillation After Aortocoronary Bypass Surgery
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: DRUG: Nux vomica (active comparator)|DRUG: Placebo (placebo comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Omega-3 Fatty Acids on Non-alcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Non Alcoholic Fatty Liver Disease
Interventions: DRUG: Omacor|DRUG: lactose tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Diagnosis and Timely Treatment of Cirrhotic Patients With Minimal Hepatic Encephalopathy (CHESS-NCRCID 2106)
Status: RECRUITING
Conditions: Hepatic Encephalopathy|Cirrhosis
Interventions: DIAGNOSTIC_TEST: Psychometric hepatic encephalopathy score & Stroop test|DRUG: Drug therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Feasibility Study of Intra-Tumoral Lipopolysaccharide Immunotherapy for Intra-Abdominal
Status: RECRUITING
Conditions: Abdominal Cancer|Malignancy
Interventions: BIOLOGICAL: Lipopolysaccharide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Metformin in Patients With Type-1 Diabetes With Inadequate Glycaemic Control by Insulin and Diet
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Metformin|DRUG: Placebo.|DRUG: Placebo.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PROphylactic triCuspID Annuloplasty in Patients With Dilated Tricuspid Annulus
Status: UNKNOWN
Conditions: Tricuspid (Valve) Insufficiency (Rheumatic)
Interventions: PROCEDURE: Mitral valve surgery|PROCEDURE: Tricuspid valve annuloplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study on the Impact of Bivalirudin Usage During PCI for High-risk Plaques on Post-PCI Coronary Microcirculation.
Status: RECRUITING
Conditions: Coronary Microvascular Dysfunction
Interventions: DRUG: Bivalirudin|DRUG: standard heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Adaptation and Initial Evaluation of Transdiagnostic CBT for Anxious and Depressed Smokers
Status: RECRUITING
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: UP-ST Therapy|BEHAVIORAL: Standard Therapy|DEVICE: Nicotine Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GABA (Gamma Amino Butyric Acid) Medication for Tobacco
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: DRUG: pregabalin|OTHER: cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cholangioscopy or Conventional Techniques for Indeterminate Biliary Stenosis
Status: UNKNOWN
Conditions: Malignant Biliary Stenosis
Interventions: PROCEDURE: endoscopic retrograde cholangiopancreatography with cholangioscopy in the first procedure of ERCP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Managed Access Programs for INC424, Ruxolitinib
Status: AVAILABLE
Conditions: Primary Myelofibrosis (PMF)|Post Polycythemia Myelofibrosis (PPV MF)|Thrombocythemia Myelofibrosis (PET-MF)|Severe/Very Severe COVID-19 Illness|Polycythemia Vera (PV)|Steroid Refractory Acute Graft Versus Host Disease (SR aGVHD)|Steroid Refractory Chronic Graft Versus Host Disease (SR cGVHD)
Interventions: DRUG: Ruxolitinib
Study Type: EXPANDED_ACCESS
Clinical trial: Adaptive Biobehavioral Control (ABC) of Automated Insulin Delivery
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: Web Simulation Tool (WST)|DEVICE: Behavioral Adaptation Module (BAM)|DEVICE: Auto Titration Module (ATM)|DEVICE: Automated Insulin Delivery (AID) System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NOX-H94
Status: COMPLETED
Conditions: Anemia|Chronic Diseases|Inflammation
Interventions: DRUG: NOX-H94|OTHER: Glucose 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Inhaled Furosemide Versus Placebo for Acute Viral Bronchiolitis in Hospitalized Infants
Status: COMPLETED
Conditions: Bronchiolitis
Interventions: DRUG: Inhaled Furosemide vs Placebo (Normal Saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of GSK3196165 Versus Placebo and Tofacitinib in Participants With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Conventional Synthetic (cs)/Biologic (b) Disease Modifying Anti-rheumatic Drugs (DMARDs)
Status: TERMINATED
Conditions: Arthritis, Rheumatoid
Interventions: BIOLOGICAL: GSK3196165 (Otilimab)|DRUG: Tofacitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Orelabrutinib Followed by Response-adapted Ultra-low Dose 4Gy Radiation as First-line Treatment of MALT Lymphoma
Status: RECRUITING
Conditions: Lymphoma, B-Cell, Marginal Zone
Interventions: DRUG: Orelabrutinib|RADIATION: response-adapted radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methadone Versus Morphine for Cancer-Related Pain
Status: TERMINATED
Conditions: Neoplasms|Pain
Interventions: DRUG: Methadone|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Vildagliptin in Type 2 Diabetes Treated With Sulphonylurea and Metformin
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: Vildagliptin|DRUG: Sulphonylurea dose-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COmparison of the Pharmacodynamics and Pharmacokinetics Ticagrelor Versus Clopidogrel in Patients With CKD and NSTE-ACS
Status: UNKNOWN
Conditions: Non ST Segment Elevation Acute Coronary Syndrome|Chronic Kidney Disease
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Cocktail Periarticular Injection in Simultaneous Total Knee Arthroplasty
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: ropivacaine, fentanyl, adrenaline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Saline Irrigation in Reducing Choledocholithiasis Recurrence After ERCP
Status: COMPLETED
Conditions: Stone - Biliary
Interventions: PROCEDURE: Saline irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study in Healthy People to Test Whether BI 730357 Affects How 4 Other Medicines (Rosuvastatin, Digoxin, Metformin, and Furosemide) Are Taken up in the Body
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 730357|DRUG: CRESTOR®|DRUG: Lenoxin®|DRUG: MetfoLiquid GeriaSan®|DRUG: Lasix®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Post-Exposure Ingavirin® Prophylaxis of Influenza and Acute Respiratory Viral Infections
Status: COMPLETED
Conditions: Influenza, Human|Acute Respiratory Infection|Common Cold|Flu|Viral Infection
Interventions: DRUG: Ingavirin (Imidazolyl Ethanamide Pentandioic Acid)|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Spine Deformity Patients With Optoelectronic Motion Capture
Status: NOT_YET_RECRUITING
Conditions: Spine Deformity
Interventions: DIAGNOSTIC_TEST: EOS x-ray|DIAGNOSTIC_TEST: Motion capture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study of Sotatercept in Japanese Pulmonary Arterial Hypertension (PAH) Participants (MK-7962-020)
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Arterial Hypertension
Interventions: BIOLOGICAL: Sotatercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integration of Yoga for the Treatment of Obesity in Adults
Status: COMPLETED
Conditions: Obesity|Physical Activity|Weight Loss|Weight Change, Body
Interventions: BEHAVIORAL: Hatha Yoga Intervention|BEHAVIORAL: Vinyasa Yoga Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Groceries for Black Residents of Boston to Stop Hypertension Among Adults Without Treated Hypertension
Status: RECRUITING
Conditions: Elevated Blood Pressure|Hypertension
Interventions: BEHAVIORAL: Dietitian-Assisted DASH groceries|BEHAVIORAL: Self-directed shopping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Plus IM-862 in Treating Patients With Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: fluorouracil|DRUG: irinotecan hydrochloride|DRUG: oglufanide disodium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Clinical Observation of Ciprofol for Anesthesia Induction
Status: NOT_YET_RECRUITING
Conditions: Anesthesia|Pain|Hemodynamic Instability
Interventions: DRUG: Propofol|DRUG: Ciprofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial of CPX-351 Lower Intensity Therapy (LIT) Plus Venetoclax as First Line Treatment for Subjects With AML
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: CPX-351|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mastalgia Treatment: Is There a Role for Osteopathic Manipulative Treatment
Status: WITHDRAWN
Conditions: Mastalgia
Interventions: OTHER: Osteopathic Manipulative Treatment|OTHER: Osteopathic Manipulative Light Touch Protocol (LT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Donepezil Hydrochloride (E2020) in Dementia Associated With Cerebrovascular Disease
Status: COMPLETED
Conditions: Dementia, Vascular
Interventions: DRUG: Donepezil Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating The Pharmacokinetics Of An Inhaled Dose Of A New Corticosteroid In Patients With Impaired Liver Function
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: GW685698X
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of the Helical Intravitreal Triamcinolone Implant in Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: triamcinolone acetonide|DRUG: triamcinolone acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Non-fixation of Mesh to Mesh Fixation in Laparoscopic Inguinal Hernia Repair
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: PROCEDURE: Mesh Fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radioembolization Trial Utilizing Eye90 Microspheres™ for the Treatment of Hepatocellular Carcinoma (HCC)
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Hepatocellular Carcinoma Non-resectable|Liver Cancer
Interventions: DEVICE: EYE90 Microspheres Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT