pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety of Aclidinium Bromide for Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) (LAS-MD-33)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Aclidinium bromide|DRUG: Aclidinium bromide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Breast Cancer Treatment Decision Aid for Women Aged 70 and Older
Status: TERMINATED
Conditions: Breast Cancer|Estrogen Receptor Positive Breast Cancer|Node-negative Breast Cancer|Human Epidermal Growth Factor 2 Negative Carcinoma of Breast
Interventions: OTHER: Breast Cancer Treatment Decision Aid for women 70+|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Does Cranioplasty Reduce Disability in Cases With Post Traumatic Skull Bone Defects
Status: UNKNOWN
Conditions: Cranioplasty|Disability Physical|Trauma
Interventions: PROCEDURE: Cranioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Camrelizumab Combined With FOLFOX Neoadjuvant Therapy for Resectable Gastric and Gastroesophageal Junctional Adenocarcinoma
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: SHR1210 combined with FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Investigating the Use of a Therapeutic Wand in Addition to Physiotherapy for Bladder Pain Syndrome
Status: COMPLETED
Conditions: Painful Bladder Syndrome
Interventions: DEVICE: Therapeutic Wand|OTHER: Routine physiotherapy control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closed-loop System Using Transcranial Direct Current Stimulation (tDCS) for Epilepsy
Status: COMPLETED
Conditions: Epilepsy|Seizures
Interventions: DEVICE: Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Metabolic Effects of a Low Carbohydrate Versus a Standard Diet in Morbidly Obese With Prediabetes
Status: COMPLETED
Conditions: PreDiabetes|Obesity, Morbid|Bariatric Surgery Candidate
Interventions: OTHER: Low carbohydrate diet|OTHER: Energy-matched standard diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Complete Decongestive Therapy With Negative Pressure for Lipedema and Lymphedema Therapy
Status: COMPLETED
Conditions: Lipedema|Secondary Lymphedema
Interventions: OTHER: CDT with graded negative pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhibition of the Renin Angiotensin System Plus Corticosteroids for the Treatment of Proteinuria in IGA Nephropathy
Status: COMPLETED
Conditions: IGA Nephropathy
Interventions: DRUG: ENALAPRIL VALSARTAN METHYLPREDNISONE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minitouch Endometrial Ablation System Treatment for Menorrhagia: An Evaluation of Safety & Effectiveness
Status: ACTIVE_NOT_RECRUITING
Conditions: Menorrhagia|Heavy Menstrual Bleeding|Heavy Uterine Bleeding
Interventions: DEVICE: Minitouch System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quadrant High Dose Rate Intraoperative Radiation Therapy (IORT) for Early-Stage Breast Cancer: A Pilot Study
Status: COMPLETED
Conditions: Breast Cancer
Interventions: RADIATION: Intra Operative Radiation Therapy (IORT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers in Samples From Adult Patients With Acute Myeloid Leukemia Who Failed Existing Standard-of-Care Treatment
Status: UNKNOWN
Conditions: Leukemia
Interventions: GENETIC: DNA methylation analysis|GENETIC: RNA analysis|GENETIC: gene expression analysis|GENETIC: microarray analysis|GENETIC: mutation analysis|GENETIC: nucleic acid sequencing|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Valaciclovir Hydrochloride Phase III for Hematopoietic Stem Cell Transplantation Patients
Status: COMPLETED
Conditions: Herpes Simplex
Interventions: DRUG: VACV tablets (Adults or pediatrics) or granules (pediatrics)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Validation of Embryo Cinematography
Status: COMPLETED
Conditions: Embryo Diagnosis and Selection
Interventions: DEVICE: Observe embryo development with "Unisense FertiliTech A/S" (EC Certificte DGM - 673)|DEVICE: Observe embryo development
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Assess the Safety and the Efficacy of the Combination of TH-302 and Sunitinib in Neuroendocrine Pancreatic Tumours
Status: COMPLETED
Conditions: Neuroendocrine Tumors|Pancreatic Neoplasms
Interventions: DRUG: TH-302 + Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Disorders Managed and Assessed Rapidly in Transient Ischemic Attack (TIA) and In Early Stroke
Status: COMPLETED
Conditions: Stroke|Ischemic Attack, Transient|Sleep Disorders|Sleep Apnea Syndromes|Restless Legs Syndrome
Interventions: OTHER: Expedited Treatment of Sleep Disorders
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose Response of Valsartan on Sitting Systolic Blood Pressure in Children 6 Months - 5 Years of Age With High Blood Pressure
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Valsartan 0.25 mg/kg|DRUG: Valsartan 1.0 mg/kg|DRUG: Valsartan 4.0 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Broad-spectrum Rapid Antidote: Varespladib IV to Oral Trial for Snakebite (BRAVIO)
Status: RECRUITING
Conditions: Snakebite|Envenoming, Snake
Interventions: DRUG: Varespladib intravenous form|DRUG: varespladib-methyl- oral form|DRUG: Placebo intravenous form|DRUG: Placebo - oral form
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Low-volume (1L) vs Intermediate-volume (2L) Bowel Preparation on Cost-effectiveness and Quality of Life
Status: COMPLETED
Conditions: Colorectal Cancer|Colonic Polyp
Interventions: DRUG: Plenvu|DRUG: Moviprep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Micronized Natural Progesterone vs GnRH Antagonist in the Prevention of LH Peak During Ovarian Stimulation.
Status: NOT_YET_RECRUITING
Conditions: IVF
Interventions: DRUG: Progesterone 200 MG|DRUG: Ganirelix Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maxillary Expansion: Leaf Expander Versus Hyrax Expander
Status: UNKNOWN
Conditions: Maxillary Deficiency
Interventions: DEVICE: orthodontic - rapid maxillary expansion|DEVICE: orthodontic - slow maxillary expansion with leaf expander|DEVICE: orthodontic - slow maxillary expansion with self leaf expander
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of Eziclen in Adult Subjects Undergoing Colonoscopy
Status: COMPLETED
Conditions: Bowel Cleansing
Interventions: DRUG: Eziclen|DRUG: Fortrans®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: To Compare the Efficacy and Safety of Tripterygium (TW) Versus Valsartan in the Diabetic Nephropathy (DN)
Status: COMPLETED
Conditions: Diabetic Nephropathy
Interventions: DRUG: TW
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer
Status: NOT_YET_RECRUITING
Conditions: Hematopoietic and Lymphatic System Neoplasm|Malignant Solid Neoplasm
Interventions: OTHER: Best Practice|PROCEDURE: Biospecimen Collection|OTHER: Electronic Health Record Review|OTHER: Survey Administration|DRUG: Triptorelin Pamoate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Establishing Immunogenicity and Safety of Needle-free Intradermal Delivery of mRNA COVID-19 Vaccine
Status: UNKNOWN
Conditions: Vaccination; Infection|COVID-19
Interventions: DEVICE: solid microneedle skin patch|BIOLOGICAL: mRNA-1273|DEVICE: standard needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Closely Grouped, Iterative Exposures to Suxamethonium During ECT on the Sensitization to NMBA and the Development of Protective Antibodies
Status: UNKNOWN
Conditions: Depression|Mania|Hallucinations
Interventions: OTHER: Iterative exposure to suxamethonium during ECT sessions
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Acute Endovascular Treatment in Symptomatic Isolated Cervical Internal Carotid Artery Occlusion Within 24 Hours of Last Seen Well (ETICA)
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: PROCEDURE: Endovascular treatment (EVT) + Best medical treatment (BMT)|PROCEDURE: Best medical treatment (BMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Back Pain
Status: RECRUITING
Conditions: Pain|Pain Syndrome|Pain, Chronic|Chronic Pain|Chronic Pain Syndrome|Back Pain|Lower Back Pain|Lower Back Pain Chronic
Interventions: DRUG: Adezunap (AP707)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Simultaneous Modulated Accelerated Boost Versus Standard Dose Radiotherapy in Esophageal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophageal Cancer
Interventions: RADIATION: Radiotherapy with simultaneous modulated accelerated boost|RADIATION: Standard dose radiotherapy|DRUG: PF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of N-acetylcysteine in the Treatment of Patients With the m.3243A>G Mutation and Low Brain Glutathione Levels
Status: RECRUITING
Conditions: Mitochondrial Disease
Interventions: DRUG: N-Acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Nonspecific Neck Pain and Central Nervous System Focused Treatment Program
Status: RECRUITING
Conditions: Neck Pain|Chronic Pain Syndrome|Rehabilitation
Interventions: OTHER: central nervous system focused treatment program|OTHER: Classical Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder (3)
Status: TERMINATED
Conditions: Generalized Anxiety Disorder
Interventions: DRUG: PD 0332334|DRUG: PD 0332334|DRUG: paroxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characteristics of Type 2 Diabetes Patients, Treated With Insulin and Their Follow up Care in Guadeloupe
Status: COMPLETED
Conditions: Type 2 Diabetes Treated With Insulin
Interventions: OTHER: Description of plans insuliniques used in Guadeloupe in the type 2 diabetes and the characteristics of the handled patients:
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PICO Negative Pressure Wound Therapy in Obese Women Undergoing Elective Cesarean Delivery.
Status: COMPLETED
Conditions: Cesarean Section Complications|Cesarean Wound; Dehiscence|Cesarean Wound Disruption
Interventions: DEVICE: PICO Negative Pressure Wound Therapy|DEVICE: Standard Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Developing a Nonpharmacological Pain Intervention for Community-dwelling Older Adults With Dementia
Status: NOT_YET_RECRUITING
Conditions: Pain, Chronic|Dementia, Mild|Mobility Limitation|Physical Disability|Osteo Arthritis Knee|Mild Cognitive Impairment
Interventions: BEHAVIORAL: Tailored Physical Activity Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I One-month Safety, PK, PD, and Acceptability Study of IVR Releasing TFV and LNG or TFV Alone
Status: COMPLETED
Conditions: HIV|Contraception
Interventions: DRUG: TFV IVR|DRUG: TFV/LNG IVR|OTHER: Placebo IVR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of Jacobson's Relaxation Techniques and Stretching Exercises in Preeclampsia
Status: RECRUITING
Conditions: Pre-Eclampsia; Complicating Pregnancy
Interventions: OTHER: walking and Stretching|OTHER: walking and Jacobsons relaxation technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Performance and Safety of the ARGOS-SC01 Suprachoroidal Pressure Sensor in Patients With Glaucoma Undergoing Non-penetrating Glaucoma Surgery
Status: COMPLETED
Conditions: Glaucoma|Open Angle Glaucoma
Interventions: DEVICE: ARGOS-SC suprachoroidal pressure sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma
Status: UNKNOWN
Conditions: Ovarian Cancer|Sarcoma|Small Intestine Cancer
Interventions: DRUG: brostallicin|DRUG: doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparison of Insulin Detemir and NPH Insulin Given Once Daily in Ageing Subjects With Type 2 Diabetes
Status: TERMINATED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin detemir|DRUG: insulin NPH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept of an Anaplerotic Study Using Brain Phosphorus Magnetic Resonance Spectroscopy in Huntington Disease
Status: COMPLETED
Conditions: Huntington Disease
Interventions: DRUG: Triheptanoin 1g/kg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Infliximab (Remicade) in Patients With Moderate to Severe Active Crohn's Disease
Status: COMPLETED
Conditions: Crohn Disease
Interventions: DRUG: infliximab or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Daily Consumption of Vitamin B12 Fortified Yoghurt on Vitamin B12 Status in Older Adults
Status: COMPLETED
Conditions: Vitamin B 12 Deficiency
Interventions: DIETARY_SUPPLEMENT: Fortified yoghurt|OTHER: Control yoghurt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Multicentre Open-label Two-arm Randomised Superiority Clinical Trial of Azithromycin Versus Usual Care In Ambulatory COVID19 (ATOMIC2)
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Azithromycin Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Hyaluronic Acid on Multiple Adjacent Gingival Recessions Using a Coronally Advanced Flap
Status: ENROLLING_BY_INVITATION
Conditions: Gingival Recession
Interventions: PROCEDURE: Testing the effectiveness of hyaluronic acid in experimental group using a coronally advanced flap compared to a control group using a coronally advanced flap only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy and Cisplatin With or Without Cetuximab in Treating Patients With HPV Positive, KRAS-Variant Stage III-IV Oropharyngeal Squamous Cell Carcinoma
Status: TERMINATED
Conditions: Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|KRAS Protein Variant|Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Pathologic Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
Interventions: BIOLOGICAL: Cetuximab|DRUG: Cisplatin|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Early Onset of Antipsychotic Drug Action in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder
Interventions: DRUG: olanzapine|DRUG: risperidone|DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oncolytic Virotherapy Plus PD-1 Inhibitor and Lenvatinib as Second-line or Later Therapy in Patients With Advanced Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Oncorine|DRUG: Tislelizumab|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effect of Multiple Doses of Zibotentan on the Pharmacokinetics of Single Doses of Combined Oral Contraceptives in Healthy Female Participants of Non-childbearing Potential.
Status: COMPLETED
Conditions: Healthy Female Participants
Interventions: DRUG: Zibotentan|DRUG: EE/LNG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chlorthalidone and HCTZ Impacts on Platelet Activation
Status: UNKNOWN
Conditions: Hypertension
Interventions: DRUG: Chlorthalidone 12.5 mg|DRUG: Hydrochlorothiazide 25 mg|DRUG: Aspirin 81 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bacteria Elimination in Retreatment Cases Using Different Disinfection Techniques
Status: COMPLETED
Conditions: Root Canal Infection|Periapical; Infection
Interventions: DEVICE: VDW Ultra|DEVICE: AMD picasso|DEVICE: ProtaperNext X3 gutta-percha
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ayres Sensory Integration Therapy on Occupational Performance in Children With Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Ayres Sensory Integration Therapy|BEHAVIORAL: Home Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: "Gluten Friendly" Treatment in Celiac Disease
Status: COMPLETED
Conditions: Food Intolerance|Celiac Disease
Interventions: OTHER: Gluten free bread|DIETARY_SUPPLEMENT: Gluten friendly bread 3g/day|DIETARY_SUPPLEMENT: Gluten friendly bread 6g/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Ibrutinib in Treating Patients With Relapsed or Refractory Transformed Indolent B-cell Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Recurrent Transformed B-Cell Non-Hodgkin Lymphoma|Refractory Transformed B-Cell Non-Hodgkin Lymphoma
Interventions: DRUG: Ibrutinib|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Laying on of Hands in Fibromyalgia
Status: RECRUITING
Conditions: Fibromyalgia
Interventions: OTHER: Laying on of hands with intention health (LHHI)|OTHER: Laying on of hands by spiritist passe|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Sugared Chewing Gum on Gastrointestinal Recovery After Major Colorectal Surgery
Status: COMPLETED
Conditions: Postoperative Ileus
Interventions: DIETARY_SUPPLEMENT: Sugared Chewing Gum (Juicy Fruit)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Three Laparoscopic Access Techniques
Status: COMPLETED
Conditions: Benign Gynecological Pathology
Interventions: PROCEDURE: laparoscopy|PROCEDURE: Laparoscopy|PROCEDURE: Laparoscopy|PROCEDURE: Laparoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Vaccination With Poly-ICLC and Dendritic Cells in Patients With Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma Non-resectable
Interventions: BIOLOGICAL: Poly-ICLC|BIOLOGICAL: dendritic cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nabilone for Cannabis Dependence: A Pilot Study
Status: COMPLETED
Conditions: Cannabis Dependence|Marijuana Dependence
Interventions: DRUG: Nabilone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aggressive Behavior Induced by Selective Serotonin Reuptake Inhibitors (SSRIs) During the First Month of Treatment
Status: COMPLETED
Conditions: Adverse Effects|Aggression
Interventions: BEHAVIORAL: comparative computer simulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Nab-paclitaxel and Gemcitabine, in Elderly Patients Untreated Metastatic Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Pancreatic Carcinoma Metastatic
Interventions: DRUG: Nab-paclitaxel 125 mg/m2 weeks 1,2,3/4|DRUG: Gemcitabine 1000 weeks 1,2,3/4
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Diet on Pregnancy Outcome and Child Obesity
Status: COMPLETED
Conditions: Pregnancy Related|Diet Modification|Obesity|Hypertension|Pre-Eclampsia|Blood Pressure|Breast Feeding|Birth Weight
Interventions: DIETARY_SUPPLEMENT: Refined Grains|DIETARY_SUPPLEMENT: Whole Grains
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Herbal Therapy for Subcutaneous Injection Site Reactions in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: OTHER: Bach's Rescue Remedy Cream|OTHER: Placebo Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Short Implant Assisted Mandibular Overdenture Designs
Status: COMPLETED
Conditions: Mandibular Bone Resorption
Interventions: OTHER: Unsplinted implants|OTHER: Splinted implants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of A-101 Solution in Subjects With Common Warts.
Status: COMPLETED
Conditions: Common Warts
Interventions: DRUG: A-101 Solution 40|DRUG: A-101 Solution 45|DRUG: Vehicle Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Lenalidomide Versus Placebo in Subjects With Transfusion Dependent Anemia in Lower Risk Myelodysplastic Syndrome (MDS) Without Del 5q
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Lenalidomide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Absorption, Metabolism, and Excretion Following a Single Dose of [14C]-Poziotinib in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: [14C]-Poziotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy Study of HYTOP® in the Treatment of Focal Chondral Defects.
Status: COMPLETED
Conditions: Focal Chondral Defect in Femoro-tibial Compartment of the Knee Joint
Interventions: DEVICE: HYTOP®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Glucose Infusion: a Novel Strategy to Improve Liver Function After Liver Resection
Status: UNKNOWN
Conditions: Hepatic Insufficiency|Liver Failure
Interventions: OTHER: Preoperative glucose infusion|OTHER: Preoperative normal saline infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Primary Posterior Tracheopexy Prevents Tracheal Collapse
Status: NOT_YET_RECRUITING
Conditions: Oesophageal Atresia With Tracheo-Oesophageal Fistula|Tracheomalacia|Oesophageal Atresia
Interventions: OTHER: Randomisation between the PPT- and no-PPT-group|PROCEDURE: Primary Posterior Tracheopexy|DIAGNOSTIC_TEST: Preoperative tracheobronchoscopy|DIAGNOSTIC_TEST: Intraoperative tracheobronchoscopy|DIAGNOSTIC_TEST: Postoperative tracheobronchoscopy through the endotracheal tube during extubation|DIAGNOSTIC_TEST: Postoperative tracheobronchoscopy after 2-6 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Post-Approval Trial of the Talent™ Abdominal Stent Graft to Treat Aortic Aneurysms
Status: COMPLETED
Conditions: Aortic Aneurysm, Abdominal
Interventions: DEVICE: Talent Abdominal Stent Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Rhabdomyolysis and Muscle Pain Associated With Mutations in the LPIN1 Gene - A Retrospective Study Describing the Safety and Efficacy of Hydroxychloroquine Sulfate Given on a Compassionate Basis to Patients Suffering From Lipin-1 Deficiency
Status: WITHDRAWN
Conditions: LIPIN1 Deficiency
Interventions: DRUG: Hydroxychloroquine Sulfate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Local Direct Median Nerve Block
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome|Anesthesia, Local
Interventions: PROCEDURE: Endoscopic carpal tunnel release under local direct median nerve block|PROCEDURE: Endoscopic carpal tunnel release under brachial plexus block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Recovery After Surgery Protocol in Improving Quality of Life in Participants With Stage 0-IIIC Gastric Cancer Undergoing Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Clinical Stage 0 Gastric Cancer AJCC v8|Clinical Stage I Gastric Cancer AJCC v8|Clinical Stage II Gastric Cancer AJCC v8|Clinical Stage IIA Gastric Cancer AJCC v8|Clinical Stage IIB Gastric Cancer AJCC v8|Clinical Stage III Gastric Cancer AJCC v8|Gastric Adenocarcinoma|Pathologic Stage 0 Gastric Cancer AJCC v8|Pathologic Stage I Gastric Cancer AJCC v8|Pathologic Stage IA Gastric Cancer AJCC v8|Pathologic Stage IB Gastric Cancer AJCC v8|Pathologic Stage II Gastric Cancer AJCC v8|Pathologic Stage IIA Gastric Cancer AJCC v8|Pathologic Stage IIB Gastric Cancer AJCC v8|Pathologic Stage III Gastric Cancer AJCC v8|Pathologic Stage IIIA Gastric Cancer AJCC v8|Pathologic Stage IIIB Gastric Cancer AJCC v8|Pathologic Stage IIIC Gastric Cancer AJCC v8
Interventions: OTHER: Best Practice|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial of HIV Vaccine Combinations in Healthy Men and Women
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: BIOLOGICAL: Ad4-EnvCN54|BIOLOGICAL: MVA-CN54|BIOLOGICAL: CN54gp140/MPLA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Intimate Partner Violence and Fatherhood Intervention in Residential Substance Abuse Treatment
Status: COMPLETED
Conditions: Intimate Partner Violence|Substance Abuse/Addiction|Child Maltreatment
Interventions: BEHAVIORAL: Fathers for Change|BEHAVIORAL: Parent Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Hypotension and Metabolomics in Major Upper Gastrointestinal Surgery
Status: NOT_YET_RECRUITING
Conditions: the Intraoperative Hypotension
Interventions: PROCEDURE: hypotension prediction index guidance|PROCEDURE: no hypotension prediction index guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Paraffin Wax Therapy vs METs in Post Burn Hand Contractures
Status: COMPLETED
Conditions: Contracture, Hand
Interventions: OTHER: Paraffin wax bath therapy|OTHER: Paraffin Wax Bath Therapy and Muscle Energy Techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Fruquitinib Combined With Camrelizumab in Non MSI-H/dMMR Refractory Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Neoplasm
Interventions: DRUG: Combination of Fruquintinib and Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrochemotherapy With Carboplatinum Plus Bleomycin Versus Bleomycin Alone in Vulvar Cancer
Status: RECRUITING
Conditions: Vulvar Cancer
Interventions: DRUG: Carboplatin|DRUG: Bleomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of SHR-1703 in Healthy Adults
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: SHR-1703|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Automated Variable Pattern Insufflator Device (AVPI) for the Acute Treatment of Migraine
Status: UNKNOWN
Conditions: Migraine Headache
Interventions: DEVICE: Automated Variable Pressure Insufflation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Equivalence of OsvaRen® Tablets and OsvaRen® Granules
Status: COMPLETED
Conditions: Hyperphosphatemia|Chronic Kidney Disease
Interventions: DRUG: Osvaren Granules|DRUG: Osvaren film-coated tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Learn How Safe Vericiguat (BAY1021189) is and the Way the Body Absorbs, Distributes and Gets Rid of Vericiguat in Participants With Liver Disease and in Age-, Weight- and Gender-matched Healthy Participants
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Vericiguat (BAY1021189)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparing the Efficacy of WeChat-based Patient Education and Conventional Patient Education in the Management of Helicobacter Pylori Eradication
Status: COMPLETED
Conditions: Helicobacter Pylori Infection Helicobacter Pylori Eradication Patient Education
Interventions: OTHER: patient education|OTHER: patient education
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of RO5428029 in Healthy Volunteers and Patients With Chronic Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C, Chronic, Healthy Volunteer
Interventions: DRUG: RO5428029|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Nimotuzumab Combined With Neoadjuvant Chemotherapy in the Treatment of Resectable LA HNSCC
Status: UNKNOWN
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Nimotuzumab Combined With Neoadjuvant Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FIH Study of RGT-419B Alone and With Endocrine Therapy in HR-Positive, HER2-Negative Advanced/Metastatic Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: RGT-419B|DRUG: RGT-419B in combination with hormonal therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Pilates and Segmental Stabilization in Elderly People With Low Back Pain
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: OTHER: Pilates Group|OTHER: Segmental Stabilization group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study With Tocilizumab [RoActemra/Actemra] Monotherapy or in Combination With Methotrexate in Patients With Rheumatoid Arthritis (PICTURE)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: tocilizumab [RoActemra/Actemra]|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of ab Interno Trabeculectomy With the Kahook Dual Blade
Status: COMPLETED
Conditions: Glaucoma, Open-Angle|Ocular Hypertension|Eye Diseases|Hypertension|Intraocular Pressure|Cataract
Interventions: PROCEDURE: Ab interno trabeculectomy|PROCEDURE: Cataract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality-based Interactive Treadmill Gait Training System for Parkinson's Disease
Status: COMPLETED
Conditions: Virtual Reality; Rehabilitation; Parkinson's Disease
Interventions: DEVICE: Virtual reality-based interactive treadmill training|DEVICE: Treadmill training without VR-based interaction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Examining the Feasibility of Prolonged Ketone Concentrate Supplement Drink Consumption in Adults With Type 2 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2|Hyperglycemia|Ketosis
Interventions: DIETARY_SUPPLEMENT: Dietary Supplement: D-β-hydroxybutyric acid with R-1,3-butanediol|OTHER: Inert placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ESAN II - Energy Sensing in Depression
Status: RECRUITING
Conditions: Immune System Tolerance|Depression|Obesity|Microbial Colonization|Diet, Healthy
Interventions: OTHER: Aronia Juice|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: An Investigation Of The Effects Of Food On The Absorption Of A Varenicline Controlled Release Formulation
Status: COMPLETED
Conditions: Pharmacokinetics|Bioavailability|Smoking Cessation
Interventions: DRUG: Varenicline Tartrate Controlled Release|DRUG: Varenicline Tartrate Controlled Release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Bipolar Hemostatic Forceps Versus Standard Therapy in Acute Non-variceal Upper GI Bleeding
Status: RECRUITING
Conditions: Gastrointestinal Hemorrhage
Interventions: PROCEDURE: Hemostatic therapy|PROCEDURE: Endoscopic therapy with hemoclip +/- injection of epinephrine solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Fluoxetine, Calcium and Placebo for the Treatment of Moderate to Severe Premenstrual Syndrome (PMS)
Status: COMPLETED
Conditions: Premenstrual Syndrome
Interventions: DRUG: Fluoxetine|DRUG: Calcium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Fluzoparib Given in Combination With Apatinib in Ovarian or Breast Cancer Patients
Status: COMPLETED
Conditions: Ovarian Cancer|Triple Negative Breast Cancer
Interventions: DRUG: Fluzoparib|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigate Absorption, Metabolism and Excretion of [14C}-Proellex Following Single Oral Dose in Healthy Females
Status: COMPLETED
Conditions: ABSORPTION|METABOLISM|EXCRETION
Interventions: DRUG: Proellex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Study of Safety and Immunogenicity of a Quadrivalent Influenza Vaccine in Healthy Adults Age 65-75 Years
Status: UNKNOWN
Conditions: Influenza
Interventions: BIOLOGICAL: VAX2012Q|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Interest of Follicular Helper Lymphocytes / Regulatory Follicular Helper Lymphocytes Ratio in IgA Nephropathy
Status: RECRUITING
Conditions: Glomerulonephritis, IGA
Interventions: OTHER: Blood collection|OTHER: Urine sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neoadjuvant and Adjuvant Therapy Studies of Sindilizumab in Resectable Lung Cancer
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Pemetrexed|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Sintilimab|DRUG: Cisplatin|DRUG: Nab paclitaxel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Examination of a Weight Loss Formula on Health
Status: COMPLETED
Conditions: Weight Loss
Interventions: DIETARY_SUPPLEMENT: Active with caffeine|DIETARY_SUPPLEMENT: Active without caffeine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Staccato Prochlorperazine Thorough QT/QTc
Status: COMPLETED
Conditions: Cardiotoxicity
Interventions: DRUG: Inhaled placebo|DRUG: Oral placebo|DRUG: Inhaled prochlorperazine 5 mg|DRUG: Inhaled prochlorperazine 10 mg|DRUG: Oral moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retention Rate and Caries Preventive Effect of Self Etch Giomer Based Fissure Sealant
Status: RECRUITING
Conditions: Fissure Sealant
Interventions: OTHER: Self etch giomer based fissure sealant (BeautiSealant, Shoufu, USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CRP-Apheresis for Attenuation of Pulmonary, MYocardial and/or Kidney Injury in COvid-19
Status: WITHDRAWN
Conditions: Covid19
Interventions: DEVICE: CRP-apheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of 162 in Subjects With Chronic Hepatitis B Virus Infection
Status: TERMINATED
Conditions: Chronic Hepatitis B Virus Infection
Interventions: DRUG: 162|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination CCI-779 (Temsirolimus) and Bortezomib (Velcade) in Relapsed and/or Relapsed/Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: CCI-779|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin
Status: COMPLETED
Conditions: Myocardial Infarction|Cardiovascular Death|Atherothrombosis|Stroke
Interventions: DRUG: Ticagrelor 90 mg|DRUG: Ticagrelor 60 mg|DRUG: Ticagrelor Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: 6 Minutes Walking Program for Terminally Ill Patients at Home or in an Institution
Status: NOT_YET_RECRUITING
Conditions: Walking Intervention
Interventions: BEHAVIORAL: 6-walking program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Stereotactic Radiation in Patients With Small Cell Lung Cancer and 1-10 Brain Metastases
Status: ACTIVE_NOT_RECRUITING
Conditions: Brain Metastases|Small Cell Lung Cancer
Interventions: RADIATION: Stereotactic Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SSIs for Mental Health and Loneliness
Status: COMPLETED
Conditions: Loneliness|Mental Health Issue|Distress, Emotional|Depression|Anxiety|Stress
Interventions: BEHAVIORAL: Overcoming Loneliness three-week intervention|BEHAVIORAL: Overcoming Loneliness single-session intervention|BEHAVIORAL: Single-session "Sharing Feelings" program|BEHAVIORAL: The Blu Surfer program: a popular online content-based intervention for psychological distress|BEHAVIORAL: The Action Brings Change (ABC) Program (TEAM Lab version)|BEHAVIORAL: Online help-seeking as usual|BEHAVIORAL: The Lonely Blu Surfer program: a popular online content-based intervention for loneliness|BEHAVIORAL: Overcoming loneliness SSI 8-minute version
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Dexpanthenol in Thermic Erythema
Status: COMPLETED
Conditions: Erythema
Interventions: DRUG: Dexpanthenol foam spray, new formulation|DRUG: Dexpanthenol foam spray, old formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mobilization of Stem Cells With AMD3100 (Plerixafor) in Multiple Myeloma Patients
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Granulocyte colony-stimulating factor plus plerixafor|DRUG: Granulocyte colony-stimulating factor plus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT