pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Inspiratory Muscle Training in Patients With Autonomic Neuropathic
Status: UNKNOWN
Conditions: Diabetes Mellitus|Diabetic Autonomic Neuropathy
Interventions: OTHER: Inspiratory muscle training (IMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate a Recombinant Staphylococcus Aureus Vaccine (Escherichia Coli) in Healthy Adults
Status: COMPLETED
Conditions: Staphylococcus Aureus Infection
Interventions: BIOLOGICAL: Inoculate Staphylococcus aureus vaccine(Escherichia Coli) at day 0-3-7|BIOLOGICAL: Inoculate Staphylococcus aureus vaccine(Escherichia Coli) at day 0/0-3-7|BIOLOGICAL: Inoculate Staphylococcus aureus vaccine(Escherichia Coli) at day 0/0-7|BIOLOGICAL: Inoculate Staphylococcus aureus vaccine(Escherichia Coli) at day 0/0-7-14
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Use of D-Cycloserine to Augment CBT for Pediatric OCD
Status: UNKNOWN
Conditions: Obsessive-Compulsive Disorder
Interventions: DRUG: D-Cycloserine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reparixin in Prevention of Delayed Graft Function After Kidney Transplantation
Status: COMPLETED
Conditions: Ischemia-Reperfusion Injury|Kidney Diseases
Interventions: DRUG: Reparixin continuous infusion|DRUG: reparixin intermittent infusion|OTHER: placebo infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Double Blinded Randomized Control Trial of Types of IVF in Children With DKA
Status: TERMINATED
Conditions: Diabetic Ketoacidosis
Interventions: DRUG: Normal saline|DRUG: Lactated Ringers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Serious Game on Hospitalized Children's Anxiety, Fear, Knowledge, and Anxiety Levels in Their Parents
Status: RECRUITING
Conditions: Serious Game on Hospitalized Children
Interventions: BEHAVIORAL: serious game
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Incretin Physiology Associated With Steroid Hormone Treatment
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Steroids
Interventions: OTHER: Oral glucose test (OGTT); isoglycaemic iv. clamp; liquid meal test; Gastric Emptying Rate; Prednisolone; Paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Endoprosthesis Metal Toxicity Study
Status: COMPLETED
Conditions: Bone Tumor|Cancer of Bone|Heart Diseases|Cognitive Impairment|Cognitive Decline|Chemotherapy Effect|Memory Problem
Interventions: BEHAVIORAL: Questionnaires|BEHAVIORAL: Interviews|DIAGNOSTIC_TEST: Blood Test|DIAGNOSTIC_TEST: Echocardiogram
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Simulation-based Low-dose High Frequency (LDHF) Plus Mobile Mentoring (m-Mentoring) Study in Nigeria
Status: COMPLETED
Conditions: Training|Capacity Building|Satisfaction
Interventions: BEHAVIORAL: Acquisition of Knowledge and clinical skills|OTHER: Onsite training|OTHER: Off-site training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Levalbuterol, Racemic Albuterol and Placebo in Subjects Twelve Years of Age and Older With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: levalbuterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Retreatment Protocol for BL22 Immunotherapy in Relapsed or Refractory Hairy Cell Leukemia
Status: TERMINATED
Conditions: Hairy Cell Leukemia
Interventions: DRUG: BL22 (CAT-3888)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supportive Care Delivered by Telemedicine to Cancer Patients at Home
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer|Supportive Care
Interventions: OTHER: In-person in clinic follow-up visit|OTHER: Telemedicine follow-up visit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ProVee Urethral Expander System IDE Study (ProVIDE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Benign Prostatic Hyperplasia With Symptomatic Lower Urinary Tract Symptoms
Interventions: DEVICE: ProVee Urethral Expander System|PROCEDURE: Urethral Access Sheath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Isokinetic Strength Training in Hemiparetic Patient With Knee Extension Thrust
Status: RECRUITING
Conditions: Hemiparesis/Hemiplegia (One Sided Weakness/Paralysis)|Gait Disorder
Interventions: BEHAVIORAL: isokinetic strength training of knee extensor and flexor muscles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Brimonidine Tartrate Nanoemulsion Eye Drop Solution in the Treatment of Dry Eye Disease (DED)
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Brimonidine Tartrate|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Early Feasibility Study
Status: NOT_YET_RECRUITING
Conditions: Hypertrophic Cardiomyopathy|Left Ventricular Septal Hypertrophy|Mitral Valve Disease|Aortic Valve Stenosis
Interventions: DEVICE: Septal Scoring Along Midline Endocardium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: L-PZQ ODT in Schistosoma Infected Children
Status: COMPLETED
Conditions: Schistosomiasis
Interventions: DRUG: L-PZQ ODT 50 mg/kg|DRUG: Biltricide®|DRUG: L-PZQ ODT 60 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ondansetron Versus Dexamethasone/Ondansetron to Treat Acute Nausea in the Emergency Department
Status: TERMINATED
Conditions: Nausea|Abdominal Pain
Interventions: DRUG: Ondansetron|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Drug Exposure in Systemic Circulation of Primatene Mist by Oral Inhalation, Versus Epinephrine Injection by Intramuscular Injection and ProAir by Oral Inhalation in Healthy Individuals
Status: COMPLETED
Conditions: Pharmacokinetics|Epinephrine|Albuterol|Asthma|Anaphylaxis
Interventions: COMBINATION_PRODUCT: Epinephrine (0.125 mg/inhalation)|COMBINATION_PRODUCT: Epinephrine Injection Auto-Injector (0.3mg/0.3mL)|COMBINATION_PRODUCT: Albuterol Sulfate (0.09 mg/inhalation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hand Injury Patients Receiving Different Rehabilitation Programs
Status: COMPLETED
Conditions: Hand Injury
Interventions: PROCEDURE: custom-made dynamic hand splint|PROCEDURE: custom-made protective hand splint|OTHER: physical therapy and occupational therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Photobiomodulation for Dry Age Related Macula Degeneration
Status: NOT_YET_RECRUITING
Conditions: Photobiomodulation|Age-Related Macular Degeneration
Interventions: DEVICE: Valeda machine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Standalone Anterior Lumbar Interbody Fusion (ALIF) L5/S1 Performed With Either rhBMP-2 or ViviGen®
Status: RECRUITING
Conditions: Spondylosis|Spondylolisthesis|Degenerative Disc Disease
Interventions: OTHER: ViviGen®|OTHER: rhBMP-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of Aliskiren in the Treatment of Diabetic Macular Edema
Status: TERMINATED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Aliskiren|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test How Well Different Doses of BI 3006337 Are Tolerated by People With Overweight or Obesity and With Fatty Liver Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-alcoholic Fatty Liver Disease|Obesity
Interventions: DRUG: BI 3006337|DRUG: Placebo matching BI 3006337
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Effectiveness of Epoetin Alfa Versus Placebo in Facilitating the Presurgical Collection of Blood to be Used for Self-donation During Surgery on the Spine, Hip, or Knee.
Status: COMPLETED
Conditions: Anemia|Blood Transfusions, Autologous|Orthopedic Procedures
Interventions: DRUG: epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of the Apexum Ablator
Status: UNKNOWN
Conditions: Periapical Periodontitis
Interventions: DEVICE: the Apexum Protocol|PROCEDURE: Conventional endodontic procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance
Status: NOT_YET_RECRUITING
Conditions: Cannabis Use|Impaired Driving|Cognitive Impairment
Interventions: DRUG: Cannabis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparing Effects of Patient-specific Versus Non-patient-specific Computerized Reminder System
Status: UNKNOWN
Conditions: Radiographic Contrast Agent Nephropathy
Interventions: OTHER: Patient-specific computerized reminder|OTHER: Non-patient-specific computerized reminder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Memory Training in Aneurysmal Subarachnoid Hemorrhage Patients
Status: TERMINATED
Conditions: Ruptured Aneurysm|Memory Deficits|Subarachnoid Hemorrhage
Interventions: DEVICE: Lumosity|DEVICE: Crossword puzzle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regional Anesthesia for Cardiothoracic Enhanced Recovery
Status: ACTIVE_NOT_RECRUITING
Conditions: Opioid Use|Anesthesia, Local|Cardiac Disease|Pain, Acute
Interventions: PROCEDURE: Bilateral ESP catheter with lidocaine|PROCEDURE: Bilateral ESP catheter with saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Induction Chemotherapy for MRF-negative, Moderate-risk, Resectable Middle and Low Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: DRUG: Oxaliplatin and capecitabine|PROCEDURE: Total Mesorectal Excision
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Back Muscles Endurance Training in Patients With Chronic Mechanical Low Back Pain
Status: COMPLETED
Conditions: Mechanical Low Back Pain|Paraspinal Muscles|Muscle Stretching Exercises
Interventions: OTHER: Muscle endurance training (MET)|OTHER: Conventional Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Study to Evaluate Safety and Efficacy of LUM001 in Patients With Primary Sclerosing Cholangitis
Status: COMPLETED
Conditions: Primary Sclerosing Cholangitis (PSC)
Interventions: DRUG: LUM001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using NIATx Strategies to Implement Integrated Services in Routine Care
Status: COMPLETED
Conditions: Addiction|Mental Health Disorder
Interventions: OTHER: Coach Site Visit|OTHER: Walk-through|OTHER: Learning Sessions|OTHER: Coaching|OTHER: Business as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bioequivalence Study Between Two Oral Formulations of Ibuprofen 800 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Bioequivalency
Interventions: DRUG: Ibuprofen Tablets, 800 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Recombinant Human Growth Hormone in Adult Growth Hormone Deficiency Patients
Status: COMPLETED
Conditions: Adult Growth Hormone Deficiency
Interventions: DRUG: HM10560A|DRUG: Genotropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Validate the Instructions for Use of TOBI® Podhaler™ in Cystic Fibrosis Patients
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Placebo|DEVICE: Tobi Podhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Comparison of Two Ventilation Methods for Micro-Laryngeal Surgery
Status: UNKNOWN
Conditions: Laryngeal Disease
Interventions: DEVICE: High-flow nasal oxygen therapy using a specific nasal cannula|DEVICE: Flow Controlled Ventilation using a laryngeal tri-tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: REFORM Clinical Study: Treatment of Renal Artery Stenosis With the Formula Balloon-Expandable Stent
Status: COMPLETED
Conditions: Renal Artery Stenosis
Interventions: DEVICE: Formula Balloon-Expandable Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Phacoemulsification-methods: HF EasyTip 2.2mm vs. HF EasyTip 2.8mm
Status: COMPLETED
Conditions: Cataracts
Interventions: PROCEDURE: cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Prospective Study of B244 Delivered as a Topical Spray to Determine Safety and Efficacy in Subjects With Elevated Blood Pressure
Status: COMPLETED
Conditions: Prehypertension|Hypertension, Stage I
Interventions: BIOLOGICAL: B244|BIOLOGICAL: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PPIO-008 Tislelizumab Combined With S-1 in Patients With ypT+N0 ESCC After Radical Resection With Neoadjuvant STUDY
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Tegafur
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: China HVT Safety, PK, PD
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: denosumab 60mg|DRUG: denosumab 120 mg|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial of SHR - 1906 in Healthy Subjects
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: SHR-1906；Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Screening for Prostate Cancer in Older Patients (PLCO Screening Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|PROCEDURE: Medical Examination|OTHER: Screening Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Music as an Adjunctive Epileptic Seizure Treatment Option
Status: RECRUITING
Conditions: Epilepsy|Neurocognitive Disorders
Interventions: OTHER: Musical Neurostimulation|OTHER: Placebo Musical Neurostimuloation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mulligan Concept Mobilisation With Movement for Shoulder Dysfunction in Older Adults
Status: COMPLETED
Conditions: Disorder of Shoulder
Interventions: OTHER: Standard protocol|OTHER: Mulligan Concept Mobilisation with Movement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block for Video-assisted Thoracoscopic Surgery
Status: UNKNOWN
Conditions: Thoracic Surgery|Peripheral Nerve Block|Analgesia
Interventions: DRUG: Ropivacaine Injection [Naropin]|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vascular Endothelium Changes After Bariatric Surgery (Endothelial Progenitor Cells)
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: pre-bariatric weight loss program|PROCEDURE: bariatric surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of TD-9855 in Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention-Deficit/Hyperactivity Disorder|ADHD
Interventions: DRUG: TD-9855|DRUG: TD-9855|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Manual Manipulation With EPAT on Ankle Dorsiflexion and Dynamic Plantar Pressure
Status: UNKNOWN
Conditions: Diabetes|Equinus Contracture of the Ankle
Interventions: DEVICE: Extra-corporeal pulsed-activated therapy or shockwave therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cross-Over Study to Assess the Cardiovascular Effects of GSK2336805
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: GSK2336805 150mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of an Evidence-based Myth-busting Information Intervention on Maternal Food Allergy Related Quality of Life, Anxiety and Self-efficacy
Status: COMPLETED
Conditions: Child Allergy|Food Allergy
Interventions: BEHAVIORAL: "Myth busting" information leaflet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Experimental Study of Strength Training to Activate the Quadriceps Muscle After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: OTHER: 1 strength training set performed until contraction failure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Evaluate the Immunogenicity and Safety of DTaP-IPV Vaccine Administered as a Boosting Dose to Healthy Children of 4-6 Years
Status: UNKNOWN
Conditions: Diphtheria|Tetanus|Pertussis|Poliomyelitis
Interventions: BIOLOGICAL: DTaP-IPV combination vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Colo-Pro_2: Bolus-continuous Infusion Cefuroxime Prophylaxis for the Prevention of Infections After Colorectal Surgery
Status: RECRUITING
Conditions: Antibiotic Prophylaxis|Colorectal Surgery
Interventions: DRUG: Cefuroxime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ketamine in Post-operative Dental Pain and Recovery
Status: COMPLETED
Conditions: Post-operative Pain
Interventions: DRUG: Ketamine|DRUG: Dexamethasone|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of DFD-03 Lotion in the Treatment of Acne Vulgaris for 12 Weeks
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: DFD-03 (0.1% tazarotene) Lotion|DRUG: DFD-03 (0% tazarotene) Lotion (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Incidence of Descemet Membrane Detachment Post GATT by AS OCT
Status: ACTIVE_NOT_RECRUITING
Conditions: Angle Glaucoma Open
Interventions: PROCEDURE: Gonioscopy-Assisted Transluminal Trabeculotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Cyclosporine for the Prevention and Treatment of Dry Eye Symptoms Following LASIK or Photorefractive Keratectomy
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: Cyclosporine, Refresh Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Wear in Composite Resin and Reinforced Acrylic Denture Teeth Used in Complete Denture Construction for Completely Edentulous Patients
Status: COMPLETED
Conditions: Wear, Occlusal
Interventions: OTHER: Bredent denture teeth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Haemoglobin And Vancomycin Pharmacokinetics in the Cerebrospinal Fluid Following Subarachnoid Haemorrhage
Status: NOT_YET_RECRUITING
Conditions: Subarachnoid Hemorrhage
Interventions: PROCEDURE: Insertion of drains|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recurrence of Liver Malignancy After Ischemia/Reperfusion Injury
Status: COMPLETED
Conditions: Ischemic Reperfusion Injury|Liver Injury|Cancer Recurrence|Malignancy|Liver Cancer
Interventions: PROCEDURE: selective hepatic vascular exclusion|PROCEDURE: semielective hepatic vascular exclusion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Role of Daily Disposable Contact Lenses in Ocular Allergy
Status: COMPLETED
Conditions: Grass Pollen Ocular Allergy
Interventions: DEVICE: Acuvue (Standard Daily Disposable Contact Lens)|DEVICE: CIBA Dailies Aquacomfort Plus (Contact Lens - enhance lubricating)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: E-learning in Patient Education to Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Patient Involvement|Self Efficacy
Interventions: OTHER: E-learning patient education|OTHER: Standard face-to-face patient education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Increasing the Reach of Promising Dropout Prevention Programs: Examining the Trade-offs Between Scale and Effectiveness
Status: UNKNOWN
Conditions: Educational Achievement
Interventions: OTHER: SAGA Innovations|OTHER: Scale-up tutors|OTHER: Standard Tutors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of the Use of Dental Floss
Status: COMPLETED
Conditions: Gingivitis
Interventions: OTHER: Instructions oral hygiene with toothbrush plus dental floss|OTHER: Instructions oral hygiene with toothbrush only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of Celecoxib on the Efficacy and Safety of Amlodipine in Subjects With Hypertension Requiring Antihypertensive Therapy
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Over-encapsulated 10 mg amlodipine besylate tablet|DRUG: Matched placebo capsule for over-encapsulated celecoxib capsule|DRUG: Over-encapsulated 200 mg celecoxib capsule|DRUG: Matched placebo capsule for over-encapsulated amlodipine besylate tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Possible Efficacy of Dapagliflozin and Atorvastatin in Patients With Major Depressive Disorders
Status: RECRUITING
Conditions: Depressive Disorder
Interventions: DRUG: Fluoxetine 20 mg|DRUG: Dapagliflozin 10mg Tab|DRUG: Atorvastatin 80mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Self-administered Acupressure in Psychiatric Patients With Constipation
Status: COMPLETED
Conditions: Constipation
Interventions: BEHAVIORAL: Self-administered acupressure|BEHAVIORAL: Sham control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study To Characterize Mass Balance, Absolute Bioavailability, Fraction Absorbed And Pharmacokinetics Of 14C PF-06882961
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: [14C]PF-06882961, 50 mg|DRUG: PF-06882961, 50 mg and [14C]PF-06882961, 100 ug
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Safety and Efficiency of Method of Exosome Inhalation in SARS-CoV-2 Associated Pneumonia.
Status: COMPLETED
Conditions: Covid19|SARS-CoV-2 PNEUMONIA|COVID-19
Interventions: DRUG: EXO 1 inhalation|DRUG: EXO 2 inhalation|DRUG: Placebo inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Tai Chi and Aerobic Exercise for Fibromyalgia (FMEx)
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: BEHAVIORAL: Lower frequency, shorter period of Tai Chi|BEHAVIORAL: Higher frequency, shorter period of Tai Chi|BEHAVIORAL: Shorter frequency, longer period of Tai Chi|BEHAVIORAL: Higher frequency, longer period of Tai Chi|BEHAVIORAL: Aerobic Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SPI-directed Analgesia for Lumbar Discectomy
Status: COMPLETED
Conditions: Lumbar Disc Disease
Interventions: DRUG: Metamizol|DRUG: Tramadol|DRUG: Bupivacaine|DRUG: Ropivacaine|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Simplified Regional Citrate Anticoagulation Protocols for CVVH, CVVHDF and SLED: a Pilot Study
Status: UNKNOWN
Conditions: Acute Renal Failure|Dialysis Related Complication|Hypophosphatemia|Hypomagnesemia
Interventions: OTHER: Renal Replacement Therapy (RRT) start
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transurethral Prostate Resection (TURP) vs. Prostate Artery Embolization (PAE)
Status: RECRUITING
Conditions: Transurethral Resection of Prostate Syndrome|Prostate Hyperplasia|Embolization, Therapeutic
Interventions: PROCEDURE: Prostate Artery Embolization|PROCEDURE: Transurethral Prostate Resection (TURP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Recurrent Caries With Lactobacilli PRECAL
Status: SUSPENDED
Conditions: Dental Caries in Children
Interventions: OTHER: Probiotic bacteria|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Obturator Nerve Block in Total Hip Arthrosplasty
Status: COMPLETED
Conditions: Primary Total Hip Arthroplasty
Interventions: OTHER: Obturator nerve block with ropivacaine 0.2%.|OTHER: Obturator nerve block with isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of TLK286 (Telcyta) vs. Gefitinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Carcinoma
Interventions: DRUG: TLK286 (Telcyta) HCl for Injection|DRUG: gefitinib (Iressa)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label, Phase 2, Proof of Concept Study in Multiple Myeloma - Denosumab
Status: COMPLETED
Conditions: Relapsed or Plateau-Phase Multiple Myeloma
Interventions: DRUG: DENOSUMAB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigation of the Effects of a Skin Serum Containing Propolis on Skin Health and Appearance
Status: RECRUITING
Conditions: Skin Health
Interventions: OTHER: Manuka Health Pro Vitality Daily Restorative Face Serum with Propolis & Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: PET/CT or PET/MRI in Measuring Tumors in Patients Undergoing Clinical Imaging or With Newly Diagnosed Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DIAGNOSTIC_TEST: positron emission tomography/computed tomography|DIAGNOSTIC_TEST: PET/MRI|DEVICE: Position Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prevention of Onset and Transition to an Advanced Form of Diabetic Retinopathy in Children
Status: RECRUITING
Conditions: Diabetic Retinopathy
Interventions: DIAGNOSTIC_TEST: Optical coherence tomography (OCTA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Tolerability, and Efficacy Study of Valoctocogene Roxaparvovec in Hemophilia A With Active or Prior Inhibitors
Status: ACTIVE_NOT_RECRUITING
Conditions: Hemophilia A With Inhibitor|Hemophilia A With Anti Factor VIII
Interventions: BIOLOGICAL: Valoctocogene roxaparvovec
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of PF-07258669 In Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: PF-07258669|DRUG: Placebo|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: EVIE-Study: Slow Release Insemination Versus Standard Intrauterine Insemination Study
Status: UNKNOWN
Conditions: Insemination
Interventions: DEVICE: EVIE|OTHER: Standard Intrauterine Insemination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunotoxin Therapy in Treating Children With Recurrent Malignant Gliomas
Status: WITHDRAWN
Conditions: Brain and Central Nervous System Tumors
Interventions: BIOLOGICAL: cintredekin besudotox|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Global Postural Reeducation and Segmental Exercises in Patients With Scapular Dyskinesis and Cervicalgia
Status: COMPLETED
Conditions: Scapular Dyskinesis|Cervicalgia
Interventions: OTHER: Global Postural Reeducation Group|OTHER: Segmental Exercises Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypofractionated Radiotherapy in Elderly Patients With Head & Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma (HNSCC)
Interventions: RADIATION: Adjuvant hypofractionation|RADIATION: Definitive Hypofractionation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Pembrolizumab (MK-3475) in Combination With Azacitidine in Subjects With Chemo-refractory Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Virtual Reality-based Balance Training on Balance of Diabetic Peripheral Neuropathy Patients
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathy
Interventions: OTHER: Virtual Reality|OTHER: Conventional Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a trAnSitional Pharmacist Intervention in geRiatric Inpatients on Hospitals Visits After dischargE
Status: ACTIVE_NOT_RECRUITING
Conditions: Drug-Related Side Effects and Adverse Reactions
Interventions: OTHER: Multifaceted clinical pharmacy intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Clinical Trial of TQB2450 Injection Combined With AL2846 Capsules in Patients With Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: TQB2450 injection|DRUG: AL2846 capsule|DRUG: Pemetrexed disodium for injection|DRUG: Cisplatin injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Efficacy of RJX in Patients With COVID-19
Status: UNKNOWN
Conditions: COVID-19|Acute Respiratory Distress Syndrome|SARS-CoV-2|Hypoxemia
Interventions: DRUG: Rejuveinix (RJX) Active Comparator|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: QFR-based Virtual PCI Versus Angio-guided PCI
Status: COMPLETED
Conditions: Percutaneous Coronary Intervention|Coronary Physiology
Interventions: OTHER: QFR-based virtual PCI|OTHER: angiography-based PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Histological Response Rate After Mastectomy and Immediate Breast Reconstruction at the End of Neoadjuvant Chemotherapy and Radiotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: PROCEDURE: Immediate mammary reconstruction|DRUG: Chemotherapy|RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced Intensity Hematopoietic Cell Transplantation for Patients With Resistant Langerhans Cell Histiocytosis
Status: TERMINATED
Conditions: Histiocytosis, Langerhans-cell
Interventions: BIOLOGICAL: alemtuzumab|DRUG: fludarabine phosphate|DRUG: melphalan|PROCEDURE: stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Lorlatinib in Advanced ALK and ROS1 Rearranged Lung Cancer With CNS Metastasis in the Absence of Measurable Extracranial Lesions
Status: UNKNOWN
Conditions: Non-Small Cell Lung Cancer (NSCLC)
Interventions: DRUG: Lorlatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Safety, Tolerability and Pharmacokinetic Profile of Intravitreous Injections of E10030 (Anti-PDGF Pegylated Aptamer) in Subjects With Neovascular Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Age-related Macular Degeneration
Interventions: DRUG: E10030
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Risankizumab in Adults and Adolescents With Moderate to Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Dermatitis
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: Risankizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Nitazoxanide Suspension in the Treatment of Diarrhea Caused by Enteric Viruses in Children
Status: COMPLETED
Conditions: Rotavirus Infection|Adenoviridae Infection|Norovirus Infection
Interventions: DRUG: Alinia (nitazoxanide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Pazopanib Monotherapy in Patients With Unresectable, Metastatic Neuroendocrine Tumor
Status: COMPLETED
Conditions: Neuroendocrine Tumor
Interventions: DRUG: Pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Umbilical Cord Blood NK Cells, Rituximab, High-Dose Chemotherapy, and Stem Cell Transplant in Treating Patients With Recurrent or Refractory B-Cell Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Mantle Cell Lymphoma|Recurrent Diffuse Large B-Cell Lymphoma|Recurrent Follicular Lymphoma|Recurrent Indolent Adult Non-Hodgkin Lymphoma|Refractory Diffuse Large B-Cell Lymphoma|Refractory Follicular Lymphoma|Refractory Indolent Adult Non-Hodgkin Lymphoma
Interventions: PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation|DRUG: Carmustine|BIOLOGICAL: Cord Blood-derived Expanded Allogeneic Natural Killer Cells|DRUG: Cytarabine|DRUG: Etoposide|BIOLOGICAL: Filgrastim|DRUG: Lenalidomide|DRUG: Melphalan|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Estrogen Administration for the Treatment of NASH in Postmenopausal Women
Status: RECRUITING
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: DRUG: Estradiol patch|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AMCPR (Augmented-Medication CardioPulmonary Resuscitation) Trial for OHCA
Status: COMPLETED
Conditions: Out-of-Hospital Cardiac Arrest
Interventions: DRUG: Vasopressins|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: FaCT Trial (Facilitated Cascade Testing Trial)
Status: RECRUITING
Conditions: BRCA1 Mutation|BRCA2 Mutation
Interventions: OTHER: Family Letter (Standard of Care)|OTHER: Educational Video|OTHER: Mailed Saliva Kit for Genetic Testing|OTHER: Telephone Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial Comparing MICARDIS® (Telmisartan) and COZAAR® (Losartan) in Patients With Mild-to-Moderate Hypertension Using Ambulatory Blood Pressure Monitoring (ABPM)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: High dose of Micardis®, once daily|DRUG: Low dose of Micardis®, once daily|DRUG: Low dose of COZAAR®, once daily|DRUG: High dose of COZAAR®, once daily|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study MORAb-066 Targeting Tissue Factor (TF)-Expressing Malignancies Including Breast, Pancreatic, Colorectal, NSCLC
Status: COMPLETED
Conditions: Breast Cancer|Pancreatic Cancer|Colorectal Cancer|Carcinoma, Non-Small-Cell Lung|Adenocarcinoma
Interventions: DRUG: MORAb-066
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Graston Tecnique Compared to Traditional Physiotherapy to Improve Range of Motion After Arthroscopic Cuff Repair.
Status: RECRUITING
Conditions: Cuff Tear Arthropathy
Interventions: OTHER: graston tecnique|OTHER: Conventional rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Mometasone Furoate/Formoterol Combination Versus Mometasone Furoate Alone in Persistent Asthmatics (Study P04334AM1)(COMPLETED)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: mometasone furoate/formoterol fumarate combination MDI 200/10 mcg BID|DRUG: Mometasone furoate MDI (MF MDI) 200 mcg|DRUG: formoterol fumarate 10 mcg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Study of Bendamustine, Rituximab, Ibrutinib, and Venetoclax in Relapsed, Refractory Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Mantle Cell Lymphoma|Lymphoma
Interventions: DRUG: BR-I (bendamustine, rituximab, ibrutinib)|DRUG: VEN (Venetoclax)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First-in-human Trial to Evaluate Safety, Tolerability, and Pharmacokinetics of APC148 in Healthy Adults
Status: NOT_YET_RECRUITING
Conditions: Healthy Subjects
Interventions: DRUG: APC148 and Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Intravenous Secukinumab in Patients With GCA or PMR
Status: RECRUITING
Conditions: Giant Cell Arteritis|Polymyalgia Rheumatica
Interventions: DRUG: Secukinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Cryotherpy on Hypertrophic Scar
Status: UNKNOWN
Conditions: Hypertrophic Scars
Interventions: DEVICE: cryotherapy (Gymna Cryoflow ICE-CT)|OTHER: Exercising, Positioning and splinting, Pressure Therapy and Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Gut Microbiota-targeted Diatery Intervention Among Older People Living With HIV
Status: NOT_YET_RECRUITING
Conditions: Hiv|Atherosclerosis|Diet, Healthy
Interventions: OTHER: dietary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Trial to Assess Safety and Efficacy of MOR202 in Anti-PLA2R + Membranous Nephropathy (aMN)
Status: COMPLETED
Conditions: Glomerulonephritis, Membranous|antiPLA2R Positive
Interventions: DRUG: MOR202
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fexofenadine Hydrochloride 180 mg Tablets Under Non-Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Fexofenadine 180 mg tablets|DRUG: ALLEGRA® 180 mg tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: ALXN1210 Versus Eculizumab in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Eculizumab
Status: COMPLETED
Conditions: Paroxysmal Nocturnal Hemoglobinuria (PNH)
Interventions: BIOLOGICAL: Ravulizumab|BIOLOGICAL: Eculizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT