pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase 1 Study of Oral QPX2015 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Bacterial Infections
Interventions: DRUG: QPX2015|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Glaucoma Adherence Study, Spain
Status: COMPLETED
Conditions: Ocular Hypertension|Primary Open Angle Glaucoma
Interventions: DRUG: Travoprost 0.004%/timolol 0.05% fixed combination eye drops (DuoTrav)|DEVICE: Travalert Dosing Aid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Safety and Tolerability of ENT-01 for the Treatment of Parkinson's Disease Related Constipation
Status: COMPLETED
Conditions: Parkinson's Disease|Constipation
Interventions: DRUG: ENT-01|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SoCal Savvy: Testing Savvy Caregiver in a Racially and Ethnically Diverse Sample in Southern California
Status: COMPLETED
Conditions: Caregiver Burnout|Psychological Distress
Interventions: BEHAVIORAL: Group sessions over 3 weeks|BEHAVIORAL: Group sessions over 6 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Alpelisib and Enzalutamide in Treating Patients With Androgen Receptor and PTEN Positive Metastatic Breast Cancer
Status: COMPLETED
Conditions: Advanced Breast Carcinoma|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Androgen Receptor Positive|HER2/Neu Negative|Metastatic Breast Carcinoma|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8|Prognostic Stage IV Breast Cancer AJCC v8|PTEN Positive|Recurrent Breast Carcinoma|Refractory Breast Carcinoma|Triple-Negative Breast Carcinoma
Interventions: DRUG: Alpelisib|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Precision Treatment of Diabetic Retinopathy Macular Edema Guided by Real-time OCT During Operation
Status: RECRUITING
Conditions: Diabetic Retinopathy
Interventions: DRUG: Ranibizumab Injection [Lucentis]|PROCEDURE: Inner limiting membrane stripping|DRUG: Dexamethasone intravitreal implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Evaluation of the Extent of Neointima Formation at 1 Month and 2 Months After Implantation Using OCT
Status: COMPLETED
Conditions: Coronary Artery Disease|Stable Angina Pectoris|Unstable Angina Pectoris
Interventions: DEVICE: BuMA Supreme™ stent|DEVICE: Xience V/Prime stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Treatments for Massive Rotator Cuff Tears: Mixed Methodology.
Status: RECRUITING
Conditions: Massive Rotator Cuff Tears|Shoulder Disease
Interventions: PROCEDURE: Conservative treatment|PROCEDURE: Arthroscopic Decompression Surgery|PROCEDURE: Reverse Prosthesis|DRUG: Pain-Relief Medication|DEVICE: Reverse Prosthesis Device
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Monitoring the IMmUological TOXicity of Drugs
Status: COMPLETED
Conditions: Arthritis|Systemic Lupus Erythematosus|Rheumatoid Arthritis|Capillary Leak Syndrome|Hepatitis
Interventions: DRUG: drug inducing arthritis, lupus, hepatitis, or capillary leak syndrom
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Plant Based Extracts and Cognition
Status: UNKNOWN
Conditions: Change in Cognitive Function and Fatigue During Extended Performance of the Cognitive Demand Battery (CDB) at 1, 3 and 6 Hours Post Consumption|Change in Long Term Declarative Memory at 1, 3 and 6 Hours Post-intervention.
Interventions: OTHER: Beverage containing plant based extracts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bevacizumab and Chemoembolization in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Liver Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: chemotherapy|DRUG: embolization therapy|PROCEDURE: hepatic artery infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of H01 in Adults With Pulmonary Hypertension Including Interstitial Lung Disease (The SATURN Study).
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Hymecromone (H01)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Epirubicin, Cisplatin and Capecitabine (ECX) Followed by Definitive Chemoradiation With/Without Surgery for Squamous Cell Carcinoma of the Oesophagus
Status: COMPLETED
Conditions: Oesophageal Carcinoma
Interventions: DRUG: Epirubicin, Cisplatin, Capecitabine|PROCEDURE: Surgical Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Efficacy and Compatibility of Efinaconazole 10% Solution (Jublia) for the Treatment of Toenail Onychomycosis in Patients Wearing Toenail Polish Compared to Those Without Polish
Status: COMPLETED
Conditions: Onychomycosis of Toenail
Interventions: DRUG: Efinaconazole 10% Topical Application Solution [JUBLIA]|OTHER: Application of Nail Polish
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-approval Study of NovoTTF-100A in Recurrent GBM Patients
Status: TERMINATED
Conditions: Recurrent Glioblastoma Multiforme
Interventions: DEVICE: NovoTTF-100A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effect of Anahil and Ibuprofen on Pain After Root Canal Therapy in Patients With Pulpitis of the Molars in Qazvin(a City in Iran)
Status: UNKNOWN
Conditions: Irreversible Pulpitis
Interventions: DRUG: Gelofen (generic name of Ibuprofen in Iran)|DRUG: Anahil ( generic name of Bromelain in Iran)|PROCEDURE: Root Canal Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel+Oxali+/-Cetux Met Gastric/GEJ
Status: COMPLETED
Conditions: Gastric Cancer Adenocarcinoma Metastatic
Interventions: DRUG: Docetaxel|DRUG: cetuximab|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Importance of the GH/IGF-1 Axis for Human Substrate and Energy Metabolism During Calorie Restriction
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GH hormone infusion|BEHAVIORAL: 42 hour fast|BEHAVIORAL: 12 hour fast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Oral Health Improvement for Nursing Home Residents Through Delegated Remotivation and Reinstruction
Status: RECRUITING
Conditions: Oral Health|Oral-health Associated Quality of Life
Interventions: OTHER: Oral Health Tool Box
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of BAI Combined With DEB-BACE of EqualSpheres in the Treatment of Advanced NSCLC
Status: NOT_YET_RECRUITING
Conditions: Carcinoma, Non-Small Cell Lung
Interventions: PROCEDURE: BAI combine with DEB-BACE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Horizons for the Treatment of Cardiomyopathy in Children
Status: COMPLETED
Conditions: Cardiomyopathy
Interventions: BIOLOGICAL: mono nuclear cells injection|DRUG: Digoxin+furosemide+captopril
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aerobic Exercise in Patients Receiving Chemotherapy for Cancer
Status: TERMINATED
Conditions: Cardiac Toxicity|Chemotherapeutic Agent Toxicity|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BEHAVIORAL: exercise intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Detection and Use of Nasal Nitrous Oxide and the Electronic Nose
Status: COMPLETED
Conditions: Allergic Rhinitis|Non-Allergic Rhinitis|Nasal Polyps
Interventions: DEVICE: Nasal nitrous oxide|DEVICE: Electronic nose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Oxygenation Efficacy of "Intrinseque Health" Non-Rebreathing Mask ("IHNRM")
Status: RECRUITING
Conditions: Respiratory Disease|Respiratory Distress Syndrome|Respiratory Failure
Interventions: DEVICE: High Flow Nasal Cannula|DEVICE: "Intrinseque Health" Non-Rebreathing Mask ("IHNRM")
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ROMTECH PortableConnect Rehabilitation Device Usage Post Unilateral Total Knee Arthroplasty (TKA)
Status: UNKNOWN
Conditions: Knee Osteoarthritis|Knee Arthritis|Knee Pain Chronic|Knee Disease|Joint Pain|Osteo Arthritis Knee|Osteoarthritis, Knee
Interventions: DEVICE: ROMTech PortableConnect|DEVICE: Traditional Rehabilitation and CPM Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Early Changes in SD-OCT After Initiation of a Treatment by Intravitreal Aflibercept (EYLEA®)START
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration of All Subtypes
Interventions: PROCEDURE: Intravitreal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Safety and Efficacy of Autologous Human Platelet Lysate for Treatment of Androgenetic Alopecia
Status: UNKNOWN
Conditions: Androgenetic Alopecia
Interventions: BIOLOGICAL: Autologous Human Platelet Lysate (HPL)|OTHER: 2 % Minoxidil and /or Finasteride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Vertebral Compression Fracture Fixation With RF Kyphoplasty in Patients With Multiple Myeloma
Status: WITHDRAWN
Conditions: Multiple Myeloma|Compression Fracture of Vertebral Column
Interventions: PROCEDURE: Kyphoplasty/Vertebral Augmentation (Device-StabiliT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient-Centered Implementation Trial for Single Embryo Transfer
Status: COMPLETED
Conditions: Male Infertility|Female Infertility|Pregnancy
Interventions: BEHAVIORAL: evidence based decision aid|BEHAVIORAL: Possible reimbursement 4th IVF/ICSI cycle when necessary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sexual Function and Quality of Life Among Patients Suffering From Inflammatory Bowel Disease(Inactive Stage)
Status: COMPLETED
Conditions: Sexual Function Disturbances|Inflammatory Bowel Diseases
Interventions: OTHER: The Arabic version of The International Index of Erectile Function (IIEF-5)|OTHER: The Sexual Quality of Life Questionnaire Male/Female (SQoL M/F)|OTHER: Assessment of depression and anxiety|OTHER: The Fatigue assessment scale (16)|OTHER: • Quality of life assessment|OTHER: The Female Sexual Function Index (FSFI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: GABA Pathways in Autism Spectrum Disorder (ASD)
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DRUG: AZD7325_10|DRUG: AZD7325_20|DRUG: Placebo|DRUG: Clobazam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Supplementing a Mixed Macronutrient Beverage With Graded Doses of Leucine on Myofibrillar Protein Synthesis
Status: COMPLETED
Conditions: Muscle Protein Synthesis
Interventions: DIETARY_SUPPLEMENT: Positive Control|DIETARY_SUPPLEMENT: Negative Control|DIETARY_SUPPLEMENT: Low Protein Low Leucine Spike|DIETARY_SUPPLEMENT: Low Protein High Leucine Spike|DIETARY_SUPPLEMENT: Low Protein + High Leucine + BCAA Spike
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Disposable Powered Articulating Linear Cutter Stapler in Gastrointestinal Tissue Cutting and Anastomosis
Status: COMPLETED
Conditions: Gastrointestinal Neoplasm
Interventions: DEVICE: Disposable Powered Articulating Endoscopic Linear Cutter Stapler|DEVICE: ECHELON Flex Powered Articulating Endoscopic Linear Cutters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root Canals
Status: RECRUITING
Conditions: Dental Pulp Necroses
Interventions: DEVICE: GentleWave System Root Canal Therapy|DEVICE: EdgePro Laser Root Canal Therapy|DEVICE: The ProUltra Piezo Ultrasonic with EndoUltra Tips Root Canal Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: App-based Remote Blood Pressure Monitoring
Status: COMPLETED
Conditions: Gestational Hypertension|Preeclampsia|Chronic Hypertension Complicating Pregnancy
Interventions: BEHAVIORAL: App-based remote blood pressure monitoring|BEHAVIORAL: text-message based remote blood pressure monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Immunotherapy and Chemotherapy Followed by Surgery in Unresectable Stage Ⅲ NSCLC
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Carrelizumab|DRUG: Pemetrexed (Nonsquamous NSCLC) or Nab-paclitaxel(Squamous NSCLC)|DRUG: Carboplatin|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cicaderma Efficacy vs Standard Care of Sites in Preventing Radiodermatitis in Non-metastatic Breast Cancer Patients
Status: UNKNOWN
Conditions: Breast Adenocarcinoma|Radiation Dermatitis|Radiation Toxicity
Interventions: DRUG: cicaderma + simple hygiene rules|OTHER: Simple hygiene rules and a maximum of one topical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Pharmacokinetic Profile
Status: COMPLETED
Conditions: Healthy Male Subjects
Interventions: DRUG: Tesomet "High dose" in fasted condition|DRUG: Tesomet "Low dose" in fasted condition|DRUG: Comperator 1 mg tesofensine, 25 mg commercial IR metoprolol, 75 mg commercial ER metoprolol, fasted condition.|DRUG: Tesomet "High dose" in fed condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: The Effect of the Hyperinsulinemic Normoglycemic Clamp on Myocardial Function and Utilization of Glucose
Status: COMPLETED
Conditions: Hyperglycemia|Aortic Valve Replacement|Aortic Stenosis|Cardiac Surgery
Interventions: OTHER: hyperinsulinemic normoglycemic clamp (HNC)|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rituximab in Treating Patients Undergoing Donor Peripheral Blood Stem Cell Transplant for Relapsed or Refractory B-cell Lymphoma
Status: COMPLETED
Conditions: B-cell Adult Acute Lymphoblastic Leukemia|B-cell Childhood Acute Lymphoblastic Leukemia|B-cell Chronic Lymphocytic Leukemia|Childhood Burkitt Lymphoma|Childhood Diffuse Large Cell Lymphoma|Childhood Immunoblastic Large Cell Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Post-transplant Lymphoproliferative Disorder|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Recurrent/Refractory Childhood Hodgkin Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Testicular Lymphoma|Waldenström Macroglobulinemia
Interventions: BIOLOGICAL: rituximab|PROCEDURE: peripheral blood stem cell transplantation|PROCEDURE: nonmyeloablative allogeneic hematopoietic stem cell transplantation|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parotid-Sparing Intensity-Modulated Radiation Therapy Compared With Conventional Radiation Therapy in Treating Patients With Oropharyngeal or Hypopharyngeal Cancer Who Are at High Risk of Radiation-Induced Xerostomia
Status: UNKNOWN
Conditions: Head and Neck Cancer|Radiation Toxicity|Xerostomia
Interventions: PROCEDURE: management of therapy complications|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparison of Cosmetic Outcomes of Lacerations Repaired Using Absorbable Versus Non-absorbable Sutures
Status: WITHDRAWN
Conditions: Lacerations|Wounds|Injuries
Interventions: PROCEDURE: Absorbable Suture Arm|DEVICE: Non-absorbable suture (Prolene)|PROCEDURE: suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Plasma Rich in Growth Factors in the Preservation of the Alveolar Ridge After Simple Molar Tooth Extractions.
Status: UNKNOWN
Conditions: Dental Implantation
Interventions: DRUG: Alveolar ridge preservation with a PRP (PRGF-Endoret)|DRUG: Blood clot and simple suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mandibular Advancement Devices Tali® in Patients With Syndrome of Obstructive Sleep Apnea and Hypopneas
Status: COMPLETED
Conditions: Syndrome of Obstructive Sleep Apnea and Hypopneas
Interventions: DEVICE: Mandibular Advancement Devices
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chromosome Abnormalities in Chronic Myeloid Leukemia (CML) on Imatinib. GIST Patients on Imatinib
Status: TERMINATED
Conditions: Chronic Myeloid Leukemia|Gastrointestinal Stromal Cell Tumors|Chromosome Abnormality
Interventions: PROCEDURE: bone marrow aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of a Quadrivalent Meningococcal Conjugate Vaccine as a Single Dose Compared With a Single Dose of a Meningococcal Reference Vaccine in Children, Adolescents, and Adults 2 to 55 Years of Age
Status: COMPLETED
Conditions: Meningococcal Immunisation (Healthy Volunteers)
Interventions: BIOLOGICAL: Meningococcal Polysaccharide (Serogroups A, C, Y, and W) Tetanus Toxoid Conjugate Vaccine (MenACYW Conjugate Vaccine)|BIOLOGICAL: Meningococcal (Groups A, C, Y and W 135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Valbenazine Treatment of Tardive Dyskinesia in Adults With Intellectual/Developmental Disabilities
Status: NOT_YET_RECRUITING
Conditions: Tardive Dyskinesia|Intellectual Disability|Developmental Disabilities
Interventions: DRUG: Valbenazine Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Postoperative Aqueous Flare After 20G Versus 23G Pars Plana Vitrectomy
Status: UNKNOWN
Conditions: Macular Hole|Macular Pucker
Interventions: PROCEDURE: 20G Vitrectomy|PROCEDURE: 23G vitrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Immunogenicity and Safety of a Booster Dose of Infanrix Hexa™ in Healthy Infants Born to Mothers Vaccinated With Boostrix™ During Pregnancy or Immediately Post-delivery
Status: COMPLETED
Conditions: Diphtheria|Hepatitis B|Acellular Pertussis|Haemophilus Influenzae Type b|Tetanus|Poliomyelitis|Diphtheria-Tetanus-aPertussis-Hepatitis B-Poliomyelitis-Haemophilus Influenzae Type b Vaccines
Interventions: BIOLOGICAL: Infanrix hexa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of MK-1084 Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant, Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004)
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: MK-1084|OTHER: Placebo|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for the Treatment of Vulvodynia
Status: COMPLETED
Conditions: Vulvodynia|Vulvar Vestibulitis|Pain|Dyspareunia|Female Sexual Dysfunction Due to Physical Condition
Interventions: OTHER: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Duration for Abdominal Tuberculosis
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: RNTCP Category I treatment for 6 months|DRUG: RNTCP Category I treatment for 9months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cyclooxygenase-2-Inhibitor Combination Treatment for Bipolar Depression
Status: COMPLETED
Conditions: Bipolar Depression
Interventions: DRUG: Escitalopram|DRUG: Celecoxib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-Pregnancy Weight Loss and Baby Behavior Study
Status: NOT_YET_RECRUITING
Conditions: Obesity; Familial|Pregnancy Related|Infant Behavior
Interventions: BEHAVIORAL: Typical Nipple|BEHAVIORAL: Challenging Nipple
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prevention of Upper Gastrointestinal Hemorrhage Using Albis® in the Patients of Locally Advanced Pancreatic Cancer Who Underwent Concurrent Chemoradiotherapy
Status: WITHDRAWN
Conditions: Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: Albis®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Clinical and Microbiological Efficacy of the Combination of Fluconazole and Secnidazole for the Treatment of Symptomatic Vaginal Discharge
Status: COMPLETED
Conditions: Vaginal Discharge
Interventions: DRUG: Fluconazole and Secnidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surveillance After Resection of Oesophageal aNd Gastric Cancer (SARONG-II) Trial
Status: NOT_YET_RECRUITING
Conditions: Esophageal Cancer|Gastric Cancer
Interventions: OTHER: Surveillance protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Preoperative Endoscopic Ultrasound-guided Fine-needle Aspiration in Cholangiocarcinoma Patients
Status: NOT_YET_RECRUITING
Conditions: Cholangiocarcinoma Patients
Interventions: DIAGNOSTIC_TEST: Endoscopic ultrasound-guided fine-needle aspiration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mitral Valve Reconstruction in Chronic Heart Failure (CHF): Identification of Predictors for a Successful Therapy
Status: TERMINATED
Conditions: Chronic Heart Failure|Mitral Insufficiency
Interventions: PROCEDURE: mitral valve repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 3 Study to Evaluate the Efficacy of XW003 Compared With Dulaglutide in Participants With T2DM
Status: ACTIVE_NOT_RECRUITING
Conditions: T2DM|Type 2 Diabetes Mellitus
Interventions: DRUG: Ecnoglutide high dosage|DRUG: Ecnoglutide low dosage|DRUG: Dulaglutide|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FRailty WAlking Patterns (FRAP) Study
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: Walking Exercises-Six Minute Walk (6MW) Test|OTHER: Walking Exercises-4 Meter Gait Speed (4MGS) Test|OTHER: Walking Exercises-Five Times Sit to Stand (FTSTS) Test|OTHER: Walking Exercises-Expanded Timed Get-Up-and-Go (ETGUG) Test|OTHER: Reveal LINQ accelerometer|OTHER: 3D accelerometer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Clinical Outcomes Following Transfer of Blastocysts Cultured From Thawed Cleavage Stage Embryos
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: Blastocyte Transferring|PROCEDURE: Embryo Transferring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Obesity and Uric Acid Stones Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Uric Acid Stones|Type 2 Diabetes Mellitus in Obese|Pre-Diabetes
Interventions: DRUG: Phentermine / Topiramate Oral Product|COMBINATION_PRODUCT: Citrate Salts, Allopurinol, Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cycloferon for Post-exposure Prophylaxis of Acute Respiratory Viral Infections and Influenza
Status: RECRUITING
Conditions: Influenza|Acute Respiratory Infection
Interventions: DRUG: Cycloferon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study To Understand Safety And Plasma Concentrations Of PF-06669571 During And Following The Oral Administration Of Single And Multiple Doses Of PF-06669571 In Healthy Volunteers Under Fasted And Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06669571|DRUG: PF-06669571|DRUG: PF-06669571|DRUG: PF-06669571|DRUG: PF-06669571|DRUG: PF-06669571|DRUG: PF-06669571
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of MEMORMAX in Subjects With MCI
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: DIETARY_SUPPLEMENT: Memormax|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lifting Effect on Recovery After Mastectomy
Status: NOT_YET_RECRUITING
Conditions: Seroma Complicating A Procedure
Interventions: BEHAVIORAL: Lifting exercise|BEHAVIORAL: Standard exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Single-dose/Multiple-doses Incremental Intravenous Injection of SY-005 （Recombinant Human Annexin A5）in Healthy Subjects
Status: COMPLETED
Conditions: Sepsis
Interventions: DRUG: SY-005
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic of Alirocumab SAR236553 (REGN727) Administered Subcutaneously at 3 Different Injection Sites in Healthy Subjects
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: alirocumab SAR236553 (REGN727)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Weight on the Population Pharmacokinetic Analysis of Doxorubicin and Cyclophosphamide
Status: COMPLETED
Conditions: Breast Cancer|Obesity
Interventions: DRUG: Doxorubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: H5N1 Vaccine Study in Japanese Adults
Status: COMPLETED
Conditions: H5N1 Influenza
Interventions: BIOLOGICAL: H5N1 (pre-)pandemic influenza vaccine (whole virion, Vero Cell derived, inactivated)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Antimicrobial Photodynamic Therapy Associated With the Conventional Endodontic Treatment: A Clinical and Microbiological Study
Status: COMPLETED
Conditions: Photochemotherapy Reaction|Dental Pulp Necrosis|Polymerase Chain Reaction|Infection|Enterococcal Infections|Candida
Interventions: RADIATION: ANTIMICROBIAL PHOTODYNAMIC THERAPY|PROCEDURE: Conventional endodontic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Switching the Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI) or Protease Inhibitor (PI) to Maraviroc in HIV Subjects
Status: COMPLETED
Conditions: HIV|HIV Infections
Interventions: DRUG: maraviroc|DRUG: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flexible Endoscopy Biopsies for Submucous Tumors With a New Drill Instrument
Status: COMPLETED
Conditions: Gastric Tumor
Interventions: DEVICE: Flexible drill biopsy instrument|DEVICE: conventional biopsy instrument
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Severity of Cardiovascular Autonomic Neuropathy in Type 1 Diabetic Patients With OSAS
Status: TERMINATED
Conditions: Sleep Apnea, Obstructive|Diabetes Mellitus, Type 1
Interventions: OTHER: to explore the severity of NAC in case of OSAS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Hydromorphone Versus Prochlorperazine + Diphenhydramine for Acute Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Hydromorphone|DRUG: Prochlorperazine|DRUG: Diphenhydramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Itraconazole Effect Study of SHR2554 on Healthy Chinese Adult Subjects
Status: COMPLETED
Conditions: Healthy Adult Subjects
Interventions: DRUG: SHR2554 and Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Testing Tactile Aids With Blind Subjects
Status: RECRUITING
Conditions: Vision, Low|Blindness
Interventions: BEHAVIORAL: Single bump acuity|BEHAVIORAL: Optimal spacing between bumps|BEHAVIORAL: Improving signal from a single bump with designer materials
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: ivWatch Sensor: Device Validation for Infiltrated Tissues
Status: COMPLETED
Conditions: Infiltration of Peripheral IV Therapy
Interventions: DEVICE: ivWatch Model 400 with SmartTouch Sensor|DEVICE: ivWatch Model 400 with Fiber Optic Sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Resistance Training Variable Manipulation in Postmenopausal Breast Cancer Survivors.
Status: UNKNOWN
Conditions: Breast Cancer Survivors|Postmenopause
Interventions: OTHER: Control group|OTHER: Lower-load resistance training (LL)|OTHER: Higher-load resistance training (HL)|OTHER: Higher-volume resistance training (HV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Unnecessary Mastectomy Due to False Size Prediction by Preoperative Imaging Studies in Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Surgery|IMAGE|Chemotherapy Effect
Interventions: DIAGNOSTIC_TEST: Preoperative imaging study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Motivational and Cognitive Intervention for College Drinkers
Status: UNKNOWN
Conditions: Alcohol Consumption|Anxiety|Depression
Interventions: BEHAVIORAL: Motivational and Cognitive Intervention for Drinkers (MCID)|BEHAVIORAL: Brief Motivational Intervention (BMI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Apomorphine on Experimental and Clinical Pain in Patients With Chronic Radicular Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: DRUG: Apomorphine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects and Plasma Concentration of Ticagrelor, After Crushed and Non-crushed Intake, After Acute Coronary Syndrome
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sitagliptin Dose Comparison Study in Patients With Type 2 Diabetes (MK-0431-077)(COMPLETED)
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: sitagliptin phosphate|DRUG: sitagliptin phosphate|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Respiratory Side Effects of Busulfan High Dose Chemotherapy in a Pediatric Population
Status: UNKNOWN
Conditions: Signs and Symptoms, Respiratory
Interventions: DRUG: busulfan|PROCEDURE: respiratory function tests|PROCEDURE: pharmacokinetics, done during the treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Reduce Sitting Time in Postmenopausal Latina Women at Increased Risk for Heart Disease
Status: COMPLETED
Conditions: Sedentary Lifestyle
Interventions: DEVICE: ActivPAL inclinometer|BEHAVIORAL: Phone counseling call: Breaking up sitting time|BEHAVIORAL: In-person counseling: Breaking up sitting time|BEHAVIORAL: Phone counseling call: Healthy living|OTHER: Tools to prompt standing|BEHAVIORAL: In-person counseling: Healthy living
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ovary Syndrome for Efficient Diagnosis and Targeted Therapy
Status: NOT_YET_RECRUITING
Conditions: Polycystic Ovary Syndrome
Interventions: PROCEDURE: laparoscopy / laparotomy|OTHER: NO INTERVENTION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Onlay vs. Inlay Patellofemoral Arthroplasty
Status: UNKNOWN
Conditions: Patellofemoral Joint|Osteoarthritis
Interventions: DEVICE: Patellofemoral Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low Dose Nivolumab in Adults Living With HIV on Antiretroviral Therapy
Status: RECRUITING
Conditions: HIV I Infection
Interventions: DRUG: Nivolumab 10 MG/ML [Opdivo]|DRUG: Nivolumab 10 MG/ML [Opdivo]|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of Lu AG06466 in Healthy Young Japanese and Caucasian Participants
Status: TERMINATED
Conditions: Healthy Volunteers
Interventions: DRUG: Lu AG06466|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of 3 Tocilizumab Products in Normal Healthy Volunteeers
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Giant Cell Arteritis
Interventions: DRUG: Tocilizumab Prefilled Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Simulation Study of a Test Material on the Anterior Nares
Status: COMPLETED
Conditions: Colonization, Asymptomatic
Interventions: OTHER: Saline applied via swab|OTHER: Povidone-iodine based gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Impact of Low-dose Dobutamine Echocardiography in Low-flow Low-gradient Aortic Stenosis
Status: UNKNOWN
Conditions: Aortic Valve Stenosis|Valvular Stenosis|Valvular Heart Disease
Interventions: DIAGNOSTIC_TEST: Dobutamine Stress Echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized Double Blind Vehicle Controlled Dose Ranging Parallel Design Multiple Site Clinical Study
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: DSXS1411|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Short-Term Effects of Ischemic Compression Applied in Addition to Classical Massage in the Treatment of Trigger Points
Status: COMPLETED
Conditions: Trigger Point Pain, Myofascial
Interventions: OTHER: Classical massage|OTHER: Ischemic compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Sleep Apnea Treatment on Physiology Traits in Chinese Patients With Obstructive Sleep Apnea
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea
Interventions: PROCEDURE: upper airway surgery|DEVICE: Continues positive airway pressure|BEHAVIORAL: education and follow up
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety of Adding IMO-2055 to Erlotinib + Bevacizumab in 2nd Line Treatment for Patients With NSCLC
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: IMO-2055
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Atomoxetine and Oxybutynin in Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea (OSA)
Interventions: DRUG: Combination product of Atomoxetine and Oxybutynin|DRUG: Placebo, 2 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tislelizumab Consolidation After Liver-Directed Therapy for Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Carcinoma, Hepatocellular|Liver Cell Carcinoma
Interventions: DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tracing the Path of an Ingested Plant Pigment Through the Human Body
Status: COMPLETED
Conditions: Metabolism and Clearance of Cyanidin 3 Glucoside
Interventions: DIETARY_SUPPLEMENT: Cyanidin 3 glucoside
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Sunobinop on Craving in Alcohol Use Disorder
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use Disorder
Interventions: DRUG: Sunobinop|DRUG: Placebo to match sunobinop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Neoadjuvant Chemotherapy Modified FOLFOX6 for Resectable Liver Metastases of Colorectal Cancers
Status: UNKNOWN
Conditions: Colorectal Cancer|Liver Metastasis
Interventions: PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polyethylene Glycol and Intestinal Inflammation in Cystic Fibrosis
Status: UNKNOWN
Conditions: Cystic Fibrosis
Interventions: DRUG: Treatment with polyethylene glycol (Macrogol 4000)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Ivosidenib in Previously Treated Japanese Subjects With Nonresectable or Metastatic Cholangiocarcinoma With an IDH1 Mutation
Status: ACTIVE_NOT_RECRUITING
Conditions: Cholangiocarcinoma Non-resectable|Cholangiocarcinoma Metastatic
Interventions: DRUG: Ivosidenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Captopril in Covid-19 Patients With Severe Acute Respiratory Syndrome (SARS) CoV-2 Pneumonia (CAPTOCOVID)
Status: UNKNOWN
Conditions: Pneumonia|Coronavirus Infection|COVID-19
Interventions: DRUG: captopril 25mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Master Study of the Acticor/Rivacor ICDs/CRT-Ds and the Plexa ProMRI S DX Lead
Status: COMPLETED
Conditions: Heart Failure|Tachyarrhythmia
Interventions: DEVICE: Acticor/Rivacor ICDs/CRT-Ds|DEVICE: Plexa S DX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Melphalan With or Without Holmium Ho 166 DOTMP Followed by Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: filgrastim|DRUG: melphalan|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: holmium Ho 166 DOTMP
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Mental Health in Fitness Instructors
Status: COMPLETED
Conditions: Mental Health Wellness 1|Depression, Anxiety|Eating Disorders|Eating Behavior|Body Image|Sexual Harassment|Exercise Addiction|Weight Change, Body|Weight Loss|Weight Gain|Leanness|Amenorrhea|Dietary Habits|Body Image Disturbance|Thinness
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Feeding Positions During Tube Feeding on Stress, Pain Level and Feeding Tolerance of Preterm Infants
Status: COMPLETED
Conditions: Pain|Stress|Enteral Feeding Intolerance
Interventions: BEHAVIORAL: ESU position|BEHAVIORAL: ESRL position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE