pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Music in Intraoperative Period
Status: COMPLETED
Conditions: Music Therapy|Perioperative Care|Postoperative Pain|Anxiety|Total Knee Arthroplasty|Vital Signs|Spinal Anesthesia
Interventions: OTHER: music therapy|OTHER: sedated group|OTHER: non-sedated group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Carvedilol Effect in Preventing Chemotherapy - Induced Cardiotoxicity
Status: COMPLETED
Conditions: Breast Cancer|Heart Failure|Cardiotoxicity
Interventions: DRUG: Carvedilol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prospective, Multicenter, Open Label and Single-arm Study of Darbepoetin Alfa for Anemia in Myelodisplastic Syndrome Patients.
Status: TERMINATED
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heliox-Powered Albuterol Therapy in the Treatment of Children Admitted With Acute Asthma Exacerbation
Status: TERMINATED
Conditions: Status Asthmaticus
Interventions: DRUG: Helium-oxygen-driven albuterol nebulizer|DRUG: Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Pilates Exercises on Forward Head Posture in Breastfeeding Women
Status: NOT_YET_RECRUITING
Conditions: Breastfeeding
Interventions: OTHER: Ergonomics breastfeeding training|OTHER: Pilates exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Oral Temanogrel on Digital Blood Flow in Adult Participants With Raynaud's Phenomenon Secondary to Systemic Sclerosis
Status: TERMINATED
Conditions: Raynaud's Phenomenon Secondary to Systemic Sclerosis
Interventions: DRUG: Temanogrel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Can the Femoral Nerve Block be Improved by Ultrasound Guidance?
Status: UNKNOWN
Conditions: Pain
Interventions: PROCEDURE: determination of method with highest efficacy (ultrasound or nerve stimulator)|PROCEDURE: nerve stimulator|PROCEDURE: loss of resistance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Addition of Non-Invasive Ventilation To Airway Clearance Techniques In Adults With Cystic Fibrosis
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: OTHER: Airway Clearance Techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 0 of 18F FPM Using PET/CT in Patients With a Variety of Malignancies
Status: TERMINATED
Conditions: Squamous Cell Carcinoma
Interventions: RADIATION: 18F FPM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Presternal Bupivacaine Plus Magnesium Sulfate Infusion After Cardiac Surgery
Status: COMPLETED
Conditions: Pain|Postoperative Pain
Interventions: DRUG: Magnesium Sulfate and Bupivacaine 0.125%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Fasting Study of Verapamil HCl Extended-Release Capsules 300 mg to Verelan® PM Extended-Release Capsules 300 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Verapamil Hydrochloride Extended-Release Capsules, 300 mg|DRUG: Verelan® PM Extended-Release Capsules, 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Apoyo Con Carino: Patient Navigation for Palliative Care for Non-Cancer Illness
Status: COMPLETED
Conditions: Palliative Care
Interventions: BEHAVIORAL: Patient Navigator Intervention Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Spectroscopic and Colorimetric Analysis of Acanthosis Nigricans in Patients With Hyperinsulinemia
Status: COMPLETED
Conditions: Acanthosis Nigricans|Hyperinsulinemia|Spectroscopic Analysis
Interventions: DRUG: Metformin|BEHAVIORAL: Dietary Modification
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Postural Tachycardia Syndrome
Interventions: DRUG: Saline|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Docosahexaenoic Acid (DHA) in Triple Negative Breast Cancer Survivors
Status: COMPLETED
Conditions: Benign Breast Neoplasm|Ductal Breast Carcinoma In Situ|Invasive Breast Carcinoma|Lobular Breast Carcinoma In Situ|Paget Disease of the Breast|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: DRUG: Docosahexaenoic Acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of 21 Gy, 23 Gy and 25 Gy for High Dose Rate (HDR) Prostate Brachytherapy
Status: RECRUITING
Conditions: Prostate Cancer|Prostate Neoplasm
Interventions: RADIATION: HDR brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: METHOD (Minimally Invasive, Endoscopically-delivered, Tolerable by Human Individuals, Non-morbid Obesity Device) Study
Status: COMPLETED
Conditions: Obesity, Non-morbid
Interventions: DEVICE: Sensate™ anchored gastric device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Preliminary Efficacy of the Combination of NaviFUS System With Re-irradiation for rGBM Patients
Status: RECRUITING
Conditions: Recurrent Glioblastoma
Interventions: DEVICE: NaviFUS System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Efficacy and Safety of Anotinib Hydrochloride Capsule Combined With Epirubicin Hydrochloride Versus Placebo Combined With Epirubicin Hydrochloride in First-line Treatment of Advanced Soft Tissue Sarcoma
Status: UNKNOWN
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: Anlotinib hydrochloride capsule|DRUG: Epirubicin|DRUG: Arotinib hydrochloride capsule placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare a New Eye Drop Formulation With Systane® Gel Drops and Genteal® Lubricant Gel Drops for Moderate to Severe Dry Eye Relief
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: Carboxymethylcellulose Sodium Based Eye Drops|DRUG: Systane® Gel Drops|DRUG: Genteal® Lubricant Gel Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Project: The Amplicon and Metatranscriptomic Study of Intra and Extra Intestinal Microbiome in Non-infectious Uveitis Disease
Status: UNKNOWN
Conditions: Autoimmune Uveitis|Behçet Disease|Vogt-Koyanagi-Harada Disease|Idiopathic Uveitis|Noninfectious Panuveitis|Anterior Uveitis Idiopathic|Posterior Uveitis|Intermediate Uveitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tight End-tidal Gas Control During Anesthesia to Decrease Postoperative Delirium Anesthetic Management
Status: UNKNOWN
Conditions: Post-Operative Confusion|Delirium|Anesthesia Complication
Interventions: PROCEDURE: Intraoperative tight control of respiratory end-tidal gases
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: De-escalated Radiotherapy for Primary Tumor After Neoadjuvant Therapy With Toripalimab Plus Chemotherapy for Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma|Radiotherapy; Complications|IMMUNOTHERAPY
Interventions: RADIATION: de-escalated radiotherapy|RADIATION: conventional radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of pCR Rate After Neadjuvant Chemotherapy Guided by Result of in Vitro Cell Culture Drug Sensitivity or Physician's Choice
Status: UNKNOWN
Conditions: Breast Cancer|Neoadjuvant Chemotherapy|Drug Effect
Interventions: COMBINATION_PRODUCT: treatment of drug screening
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: taVNS for Letter Learning in Dyslexia
Status: NOT_YET_RECRUITING
Conditions: Dyslexia
Interventions: DEVICE: active taVNS|DEVICE: sham taVNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multilayer Biological Characterization of Advanced Follicular Lymphoma: a Translational Study From FIL_FOLL12 Trial
Status: RECRUITING
Conditions: Follicular Lymphoma
Interventions: DIAGNOSTIC_TEST: EZH2 mutations/CNAs by droplet digital PCR (ddPCR)|DIAGNOSTIC_TEST: EZH2-derived gene expression signature by RNA-Seq
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Evaluating Prevnar Infant Long-term Immune Response Versus Prevnar Naive Cohort
Status: COMPLETED
Conditions: Pneumococcal Conjugate Vaccine
Interventions: BIOLOGICAL: 13-valent Pneumococcal Conjugate Vaccine|BIOLOGICAL: 13-valent Pneumococcal Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Precision Medicine Guided Treatment for Cancer Pain
Status: COMPLETED
Conditions: Pain|CYP2D6 Polymorphism
Interventions: GENETIC: CYP2D6|BEHAVIORAL: Brief Pain Inventory-Short Form (BPI-SF)|BEHAVIORAL: M.D. Anderson Symptom Inventory (MDASI)|GENETIC: OPRM1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vemurafenib Plus Cobimetinib in Metastatic Melanoma
Status: TERMINATED
Conditions: Metastatic Melanoma
Interventions: DRUG: Vemurafenib plus cobimetinib|DEVICE: Positron Emission Tomography|PROCEDURE: Tissue sampling|PROCEDURE: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of AG-270 in Participants With Advanced Solid Tumors or Lymphoma With MTAP Loss
Status: TERMINATED
Conditions: Advanced Solid Tumors|Lymphoma
Interventions: DRUG: AG-270|DRUG: AG-270|DRUG: AG-270|DRUG: docetaxel|DRUG: nab-paclitaxel|DRUG: gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-Habilitation With Mindfulness and Exercise for Patients Undergoing Radical Cystectomy (PRIMER Trial)
Status: RECRUITING
Conditions: Bladder Cancer|Non-muscle-invasive Bladder Cancer|Muscle-Invasive Bladder Carcinoma
Interventions: BEHAVIORAL: Pre-operative physical exercise|BEHAVIORAL: Pre-operative mindfulness meditation practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of hCT-MSC in Newborn Infants With Moderate or Severe HIE
Status: COMPLETED
Conditions: Moderate to Severe Hypoxic-ischemic Encephalopathy
Interventions: BIOLOGICAL: Infusion of hCT-MSC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Participants With Familial Chylomicronemia Syndrome (FCS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Familial Chylomicronemia Syndrome
Interventions: DRUG: Olezarsen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Qualitative Study in Patients With Genodermatoses and Healthcare Professionals on Reproductive Counselling
Status: RECRUITING
Conditions: Quality of Life|Ichthyosis|Palmoplantar Keratoses|Epidermolysis Bullosa|Ectodermal Dysplasia|Basal Cell Nevus Syndrome|Birt-Hogg-Dube Syndrome|Tuberous Sclerosis|Cutis Laxa|Albinism
Interventions: OTHER: Qualitative interview
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Non-Invasive Measurement of SjvO2 Using Near Infrared Spectroscopy in Patients Undergoing Liver Transplantation Surgery
Status: COMPLETED
Conditions: Impaired Oxygen Delivery|Transplant; Failure, Liver
Interventions: DEVICE: VO 100 medical device from Mespere LifeSciences
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Remimazolam Use During Perioperative Period on Brain Waves and Postoperative Cognitive Function
Status: COMPLETED
Conditions: Benzodiazepine
Interventions: DRUG: remimazolam group was induced with remimazolam 0.1 mg/kg followed by a maintenance dose of 0.1 mg·kg-1·h-1 for general anesthesia|DRUG: control group was induced with midazolam 0.05 mg/kg followed by normal saline maintenance of 0.1 ml·kg-1·h-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Research Study in People With Type 2 Diabetes to Compare Two Types of Insulin: Insulin 287 and Insulin Glargine
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin icodec|DRUG: Insulin glargine U100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Additional Glucose Lowering and Anti-Inflammatory Effects by Acarbose and Alcohol in Subjects With Impaired Glucose Tolerance or Mild Type 2 Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus|Impaired Glucose Tolerance
Interventions: DRUG: Acarbose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Comparative Study About the Effect of Vertebral Body Decompression Procedure
Status: COMPLETED
Conditions: Osteoporotic Vertebral Compression Fracture
Interventions: PROCEDURE: Decompression|PROCEDURE: Conservative Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Theta Burst Stimulation for Gambling Disorder
Status: RECRUITING
Conditions: Gambling Disorder
Interventions: DEVICE: theta burst stimulation|DEVICE: sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of An Exergame for Caregivers of Individuals With Alzheimer's Disease or Related Dementias
Status: COMPLETED
Conditions: Sedentary Lifestyle|Stress, Psychological
Interventions: BEHAVIORAL: Exergame Experience
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Induction of Suction Blisters in Patients With Urticaria, Blistering Diseases, Inflammatory Dermatoses and Neoplastic Disorders, and in Normal Volunteers
Status: COMPLETED
Conditions: Dermatitis|Healthy|Neoplasm|Urticaria|Vesiculobullous Skin Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Integrative Body-Mind-Spirit Group Intervention for Infertile Couples
Status: NOT_YET_RECRUITING
Conditions: Infertility
Interventions: BEHAVIORAL: Couple-based I-BMS intervention for infertility
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Oxytocin (OT) and Oxytocin Plus Human Chorionic Gonadotropin (hCG), in Cycles Induced by Letrozole or Clomiphene Citrate
Status: COMPLETED
Conditions: Ovarian Response
Interventions: DRUG: letrozole , oxytocin,hCG,clomiphene citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Open-label Randomized Controlled Trial (RCT) to Compare Colistin Alone Versus Colistin Plus Meropenem
Status: COMPLETED
Conditions: Gram-Negative Bacterial Infections
Interventions: DRUG: Colistin|DRUG: Meropenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Eribulin Mesylate Administered Biweekly (Q2W) for Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Eribulin Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4144 as Well as the Impact of AZD4144 on the Pharmacokinetics of Rosuvastatin in Healthy Participants
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: AZD4144- Part A|DRUG: Placebo- Part A|DRUG: AZD4144- Part B|DRUG: Placebo- Part B|DRUG: Rosuvastatin- Part C|DRUG: Rosuvastatin and AZD4144 Part C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Hypochlorous Acid as Prophylaxis in Health Personnel at High Risk of Infection by SARS-CoV 2 (COVID19)
Status: WITHDRAWN
Conditions: SARS-CoV Infection|Covid19|Infection Viral
Interventions: DRUG: Stabilized hypochlorous acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 1 Study of Gene-modified Autologous Hematopoietic Stem Cell (BD211) Treating β-thalassemia Major
Status: RECRUITING
Conditions: β-thalassemia
Interventions: GENETIC: BD211
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Compare the Safety and Efficacy of an Aliskiren-based Regimen With a Lisinopril Based Regimen in Patients With Severe Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: aliskiren
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Pelvic Floor Muscle Training in Treating Urinary Incontinence in Gynecologic Cancer Survivors
Status: COMPLETED
Conditions: Cervical Cancer|Endometrial Cancer|Ovarian Epithelial Cancer|Ovarian Germ Cell Tumor|Uterine Sarcoma|Vulvar Cancer
Interventions: OTHER: questionnaire administration|PROCEDURE: standard follow-up care|OTHER: educational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prenatal Diagnosis of Antenatal Midgut Volvulus: Specific Ultrasound Features
Status: COMPLETED
Conditions: Fetal Volvulus|Midgut Volvulus
Interventions: OTHER: Fetal ultrasound during the second or third trimester/ Postnatal surgery / Post mortem examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment to Regress to Normoglycemia in Women With a Recent History of GDM
Status: RECRUITING
Conditions: Pre Diabetes|Postpartum Disorder
Interventions: DRUG: Semaglutide Pen Injector [Ozempic]|DRUG: Placebo semaglutide pen injector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Plus Radiation Therapy With or Without Surgery in Treating Patients With Stage IIIA Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: etoposide|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Effect of Belatacept on Pharmacokinetics of Inje Cocktail in Healthy Volunteers
Status: COMPLETED
Conditions: Transplant Rejection
Interventions: DRUG: Caffeine|DRUG: Losartan|DRUG: Omeprazole|DRUG: Dextromethorphan|DRUG: Midazolam|BIOLOGICAL: Belatacept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: New Retinoid Agent Combined With Arsenic Trioxide for Untreated Acute Promyelocytic Leukemia
Status: WITHDRAWN
Conditions: Acute Promyelocytic Leukemia
Interventions: DRUG: NRX 195183 (retinoid analogue)|DRUG: Arsenic Trioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Exploratory Study on the Nicotinamide Mononucleotide (Vital NAD ) to Promote the Rejuvenation of the Peripheral Blood Immune Cells of Adults.
Status: NOT_YET_RECRUITING
Conditions: Enhance Immune Function
Interventions: DRUG: NMN
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study On Safety Of Laparoscopic Total Gastrectomy For Clinical Stage I Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: PROCEDURE: Laparoscopic total gastrectomy|PROCEDURE: Open total gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BI 1356 BS in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: BI 1356 BS - single rising dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Effect of Osimertinib (TAGRISSO™ ) on Blood Levels of Fexofenadine in Patients With EGFRm+ NSCLC
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Fexofenadine tablet dosing|DRUG: Osimertininb tablet dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sutured vs Sutureless Mesh Fixation for Onlay Ventral Hernia Repair
Status: NOT_YET_RECRUITING
Conditions: Ventral Hernia
Interventions: PROCEDURE: Ventral hernia repair with mesh fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Determine the MTD and to Evaluate the Safety, Efficacy and PK Profiles of TSB-9-W1 in Pre-treated Patients With mCRC.
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: TSB-9-W1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Plant-Based Protein-rich Food Products With Varying Degree of Processing on the Human Gut Microbiome Composition and Human Metabolome
Status: RECRUITING
Conditions: Metabolism|Gut Microbiota|Inflammation
Interventions: BEHAVIORAL: Unprocessed|BEHAVIORAL: Mildly processed|BEHAVIORAL: Heavily refined
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: IBI376 Plus Rituximab in Patients With Untreated Indolent Lymphoma.
Status: RECRUITING
Conditions: Inert Non Hodgkin's Lymphoma
Interventions: DRUG: IBI376|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Nonsurgical Treatment of Intermittent Claudication Due to Femoro-popliteal Disease
Status: COMPLETED
Conditions: Femoropopliteal Disease|Intermittent Claudication
Interventions: PROCEDURE: Percutaneous Transluminal Angioplasty (PTA)|PROCEDURE: Supervised Exercise Programme (SEP)|PROCEDURE: Combined Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Bruton's Tyrosine Kinase Inhibitor, PCI-32765 (Ibrutinib), in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With Newly Diagnosed Non-Germinal Center B-Cell Subtype of Diffuse Large B-Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Ibrutinib|DRUG: Placebo|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone (or equivalent)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Differences in Schizophrenia With One-month and 3-month Paliperidone Palmitate Treatment
Status: COMPLETED
Conditions: Schizophrenics
Interventions: DRUG: Paliperidone Palmitate 156 MG/ML Prefilled Syringe [Invega]|DRUG: Paliperidone Palmitate 546 MG Intramuscular Suspension, Extended Release [INVEGA TRINZA]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assess the Efficacy of Radiotherapy and Sequential Chemotherapy and AK104 Before TME Surgery for Local CRC（AK104-IIT-13）
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Rectal Cancer
Interventions: DRUG: AK104 injection|PROCEDURE: TME surgery|DRUG: Capecitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weight Loss in Chronic Disease Patient Population
Status: COMPLETED
Conditions: Overweight|Obesity|Diabetes|Hypertension
Interventions: DEVICE: Tele-health Home Monitoring|BEHAVIORAL: TrestleTree Telephone Coaching|DEVICE: Tele-health Home Monitoring Plus Trestle Telephone Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Investigation of the Vision-R800 Device.
Status: COMPLETED
Conditions: Myopia|Hyperopia|Astigmatism|Presbyopia
Interventions: DEVICE: Vision R-800 Phoropter|DEVICE: Standard Phoropter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Targeting Cognition in Early Alzheimer's Disease by Improving Sleep With Trazodone
Status: RECRUITING
Conditions: AMCI - Amnestic Mild Cognitive Impairment|Sleep Disturbance
Interventions: DRUG: Trazodone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pomalidomide After Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Chronic Myelomonocytic Leukemia-2|High Risk Myelodysplastic Syndrome|Myeloproliferative Neoplasm
Interventions: DRUG: Cytarabine|DRUG: Daunorubicin Hydrochloride|DRUG: Etoposide|DRUG: Idarubicin Hydrochloride|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endometrial Preparation Before Operative Hysteroscopy in Premenopausal Women
Status: UNKNOWN
Conditions: Uterine Fibroids
Interventions: PROCEDURE: operative hysteroscopy|DRUG: Dienogest|DRUG: Ulipristal acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Efficacy of Lebrikizumab (LY3650150) in Adolescent Participants With Moderate-to-Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: BIOLOGICAL: Lebrikizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crestal vs Lateral Sinus Lift Augmentation
Status: COMPLETED
Conditions: Edentulous Alveolar Ridge|Bone Atrophy, Alveolar
Interventions: PROCEDURE: Maxillary sinus augmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Natural Killer (NK) Cells for Ovarian, Fallopian Tube, Peritoneal and Metastatic Breast Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Cancer|Breast Cancer
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Cyclosporine|BIOLOGICAL: Natural killer cells|DRUG: IL-2|DRUG: Methylprednisolone|DRUG: Methylprednisolone|DRUG: Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile Health Application of Disease Self-Management in Non-Small Cell Lung Cancer Patients During Targeted Therapy
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: OTHER: disease self-management application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors
Status: UNKNOWN
Conditions: Childhood Germ Cell Tumor|Extragonadal Germ Cell Tumor|Ovarian Cancer
Interventions: BIOLOGICAL: bleomycin sulfate|DRUG: carboplatin|DRUG: cisplatin|DRUG: etoposide|DRUG: ifosfamide|DRUG: vinblastine sulfate|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Whole-body Vibration as add-on Treatment of Osteoporosis in Post-menopausal Women
Status: COMPLETED
Conditions: Osteoporosis in Post-menopausal Women
Interventions: DEVICE: Whole body vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interpretation of Health News Items Reporting Results of Randomized Controlled Trials With or Without Spin by French-speaking Population
Status: WITHDRAWN
Conditions: The Study Focus on no Specific Condition
Interventions: OTHER: News items with spin|OTHER: News items without spin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effects of Immunonutrition in Patients With Pneumonia
Status: UNKNOWN
Conditions: Pneumonia|Lung Infection|Muscle Loss|Malnutrition|Pulmonary Disease
Interventions: DIETARY_SUPPLEMENT: Oral Impact powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacodynamic Study of Two Lanthanum Carbonate Formulations in Healthy Adults
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DRUG: Lanthanum carbonate Granule Formulation|DRUG: Lanthanum carbonate Chewable Tablets (Fosrenol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Ph 2 Trial of Vitamin C & G-FLIP (Low Doses Gemcitabine, 5FU, Leucovorin, Irinotecan, Oxaliplatin) for Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: G-FLIP|DRUG: G-FLIP-DM|DIETARY_SUPPLEMENT: Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Educational Program for Various Health Literacy Levels to Improve the Health of Individuals With Heart Failure
Status: COMPLETED
Conditions: Heart Failure, Congestive
Interventions: BEHAVIORAL: Teach to Goal (TTG)|BEHAVIORAL: Brief Educational Intervention (BEI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Voice Rest and Injection Laryngoplasty
Status: RECRUITING
Conditions: Vocal Cord Paralysis
Interventions: BEHAVIORAL: Voice Rest|BEHAVIORAL: No Voice Rest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gleevec as Maintenance Therapy After Cytogenetic Response With Nilotinib in Newly Diagnosed Chronic Myelogenous Leukemia
Status: RECRUITING
Conditions: Chronic Myelogenous Leukemia
Interventions: DRUG: Nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Isopropyl Alcohol Versus Placebo to Manage Nausea at Electronic Dance Music Festivals
Status: RECRUITING
Conditions: Nausea
Interventions: DRUG: Isopropyl alcohol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Levetiracetam in Patients Suffering From Idiopathic Generalized Epilepsy With Primary Generalized Tonic-clonic Seizures
Status: COMPLETED
Conditions: Generalized Convulsive Epilepsy
Interventions: DRUG: Levetiracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: Low-frequency Repetitive Nerve Stimulation in Myotonic Dystrophy Type 1
Status: COMPLETED
Conditions: Myotonic Dystrophy 1
Interventions: DIAGNOSTIC_TEST: Low frequency repetitive stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: TSPO PET as a Measure of Post-stroke Brain Inflammation: a Natural History Cohort
Status: COMPLETED
Conditions: Stroke, Ischemic|Inflammatory Response|Stroke, Acute
Interventions: DIAGNOSTIC_TEST: Brain Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects Of Chlorhexidine Mouthrinse On Peridontopathogens: A Randomized, Placebo-Controlled Study
Status: COMPLETED
Conditions: This Study Evaluated the Effectiveness of Chlorhexidine Mouthrinse on Subgingival Microbiota
Interventions: DRUG: Chlorhexidine gluconate|DRUG: Placebo mouthrinse
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Evaluation of the Medidux™ Digital Health Application in Patients With HER2-positive Breast Cancer During Chemotherapy in Combination With HER2-targeted Therapy or Antibody-drug Conjugate Therapy.
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DEVICE: medidux™ app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: LMB-2 Immunotoxin in Treating Young Patients With Relapsed or Refractory Leukemia or Lymphoma
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: BIOLOGICAL: LMB-2 immunotoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Uterine Transplantation and Pregnancy Induction in Women Affected by Absolute Uterine Infertility
Status: ACTIVE_NOT_RECRUITING
Conditions: Absolute Uterine Infertility
Interventions: PROCEDURE: Uterine Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Manual Therapy Protocol in Patients With Masticatory Muscle Disorders
Status: COMPLETED
Conditions: Temporomandibular Disorder
Interventions: OTHER: Manual Therapy protocol|OTHER: Effleurage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CheckpOiNt Blockade For Inhibition of Relapsed Mesothelioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Mesothelioma
Interventions: DRUG: Nivolumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SMS Messaging as a Tool to Improve Cancer Screening Programs
Status: UNKNOWN
Conditions: Mass Screening|Colorectal Cancer|Breast Cancer
Interventions: BEHAVIORAL: SMS reminders to enhance colorectal cancer screening|BEHAVIORAL: SMS reminders to return the fecal immunochemical test at the pharmacy in CRC screening:|BEHAVIORAL: Invitation by SMS to previous participants in breast cancer screening:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intravenous Versus Oral Iron Therapy in Hemodialysis Patients
Status: UNKNOWN
Conditions: Hemodialysis Complication|Anemia|Iron Deficiency Anemia
Interventions: DRUG: Intravenous iron|DRUG: Oral iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inhaled Iloprost for Sarcoidosis-associated Pulmonary Hypertension
Status: COMPLETED
Conditions: Sarcoidosis|Pulmonary Arterial Hypertension
Interventions: DRUG: Iloprost
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Bevacizumab in Agioid Streaks
Status: COMPLETED
Conditions: Angioid Streaks|Choroidal Neovascularization
Interventions: DRUG: intravitreal injection|DRUG: intravitreal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Fasting Towards Elevated Blood Pressure
Status: COMPLETED
Conditions: Intermittent Fasting|Elevated Blood Pressure
Interventions: BEHAVIORAL: Intermittent fasting|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Anlotinib , Penpulimab Combined With SBRT for Metastatic Non-Small Cell Lung Cancer (NSCLC)
Status: NOT_YET_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Anlotinib Hydrochloride|DRUG: penpulimab|RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab for Pediatric and Adult Relapsing/Refractory ALK+, for Evaluation of Response in Patients With Progressive Disease (Cohort 1) or as Consolidative Immunotherapy in Patients in Complete Remission After Relapse (Cohort 2)
Status: RECRUITING
Conditions: Relapsing/Refractory ALK+ Anaplastic Large Cell Lymphoma
Interventions: DRUG: Nivolumab cohort 1|DRUG: Nivolumab cohort 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Lonafarnib in Patients With Recurrent Squamous Cell Carcinoma of the Head and Neck (Study P02530)
Status: TERMINATED
Conditions: Carcinoma, Squamous Cell|Head and Neck Neoplasms
Interventions: DRUG: Farnesyl Protein Transferase Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgery Versus Endoscopic Resection for Incompletely Removed Early Colon CAnceR
Status: RECRUITING
Conditions: Treatment Side Effects|Colorectal Cancer
Interventions: PROCEDURE: Tumor removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Efficacy of Dura Sealant Patch in Reducing CSF Leakage Following Elective Cranial Surgery
Status: COMPLETED
Conditions: Cerebrospinal Fluid Leak
Interventions: DEVICE: LIQOSEAL|DEVICE: DuraSeal, Adherus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Resistance and Cardiorespiratory Time-matched Exercise in Youth: A Randomized Clinical Trial (RCT:RCT)
Status: TERMINATED
Conditions: Childhood Obesity
Interventions: OTHER: Aerobic Exercise|OTHER: Resistance Exercise|OTHER: Aerobic and Resistance Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Rapamycin (Sirolimus) in the Treatment of Peutz-Jeghers Syndrome
Status: UNKNOWN
Conditions: Peutz-Jeghers Syndrome
Interventions: DRUG: Rapamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ZD6474 to Treat Advanced Brain Cancer in Patients
Status: COMPLETED
Conditions: Recurrent High-Grade Gliomas|Progressive Low-Grade Gliomas|Malignant Gliomas
Interventions: DRUG: Steroids|DRUG: ZD6474
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Post-marketing, Observational, Retrospective Study to Assess the Safety of RefortrixTM (Tdap) When Administered During Pregnancy in a Maternal Immunization Program in Brazil.
Status: COMPLETED
Conditions: Diphtheria
Interventions: BIOLOGICAL: Combined diphtheria, tetanus and tricomponent acellular pertussis vaccine [Refortrix (Tdap)]
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lateral Invagination of the Colorectal Anastomosis by Double Stapling
Status: UNKNOWN
Conditions: Anastomotic Leak|Sigmoid Diseases
Interventions: PROCEDURE: Doubled-stapled colorectal anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Lubiprostone in Patients With Irritable Bowel Syndrome With Constipation
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Constipation
Interventions: DRUG: Lubiprostone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Arrhythmic Risk Stratification in Nonischemic Dilated Cardiomyopathy
Status: RECRUITING
Conditions: Sudden Cardiac Death Due to Cardiac Arrhythmia|Dilated Cardiomyopathy
Interventions: DEVICE: Implantable Cardioverter Defibrillator (ICD) insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Rituximab, Lenalidomide, and Nivolumab in Treating Participants With Relapsed or Refractory Non-Germinal Center Type Diffuse Large B Cell Lymphoma or Primary Central Nervous System Lymphoma
Status: TERMINATED
Conditions: Recurrent Central Nervous System Lymphoma|Recurrent Diffuse Large B-Cell Lymphoma|Refractory Central Nervous System Lymphoma|Refractory Diffuse Large B-Cell Lymphoma
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: Rituximab|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Maintenance of the Efficiency and Adverse Effects of Pharmacological Treatments in Sex Offenders With Paraphilia
Status: NOT_YET_RECRUITING
Conditions: Paraphilia
Interventions: BEHAVIORAL: Evaluation Scales|OTHER: osteodensitometry|BIOLOGICAL: blood samples|OTHER: ECG|GENETIC: Blood and saliva samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of Endoscopic Ultrasound-Guided Portal Pressure Gradient Measurement
Status: RECRUITING
Conditions: Liver Diseases
Interventions: PROCEDURE: Endoscopic Ultrasound-Guided Portal Pressure Gradient Measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The RIME Study - Combined Occipital and Supraorbital Transcutaneous Nerve Stimulation for Treatment of Migraine
Status: COMPLETED
Conditions: Acute Migraine
Interventions: DEVICE: Relivion active|DEVICE: Relivion Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotic Prophylaxis for Immunosuppressant Associated Diarrhea (IAD) Following Kidney Transplantation
Status: COMPLETED
Conditions: Immunosuppressant Associated Diarrhea
Interventions: DRUG: Probiotic Supplement|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION