pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Larotaxel Compared To Continuous Administration of 5-FU in Advanced Pancreatic Cancer Patients Previously Treated With A Gemcitabine-Containing Regimen
Status: COMPLETED
Conditions: Pancreatic Neoplasms
Interventions: DRUG: Larotaxel (XRP9881)|DRUG: 5-Fluorouracil|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Fitness Drink Formulas on Energy Expenditure and Fat Metabolism
Status: COMPLETED
Conditions: Caffeine|Diet, Healthy|Fat Burn|Cognitive Change|Fatigue
Interventions: DIETARY_SUPPLEMENT: Fitness Drink Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Family Routines Enhancing Adolescent Diabetes by Optimizing Management
Status: UNKNOWN
Conditions: Type 1 Diabetes
Interventions: BEHAVIORAL: Sleep Extension|BEHAVIORAL: Routine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Toripalimab Combined With Anlotinib, Etoposide and Platinum in the Treatment of Extensive-stage Small Cell Lung Cancer
Status: UNKNOWN
Conditions: SCLC, Extensive Stage|Lung Cancer|Small Cell Lung Cancer
Interventions: DRUG: Toripalimab|DRUG: Anlotinib|DRUG: Cisplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: QUILT-3.057: NANT Neoadjuvant Triple- Negative Breast Cancer (TNBC) Vaccine
Status: WITHDRAWN
Conditions: Triple Negative Breast Cancer (TNBC)
Interventions: DRUG: Leucovorin|DRUG: 5-Fluorouracil|DRUG: Aldoxorubicin HCl|DRUG: nab-Paclitaxel|BIOLOGICAL: ETBX-011|BIOLOGICAL: ETBX-051|BIOLOGICAL: ETBX-061|BIOLOGICAL: GI-4000|BIOLOGICAL: GI-6207|BIOLOGICAL: GI-6301|DRUG: Avelumab|BIOLOGICAL: ALT-803|BIOLOGICAL: haNK|DRUG: Cyclophosphamide|DRUG: Doxorubicin HCL|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalizing Preprocedural Sedation for Regional Anesthesia
Status: COMPLETED
Conditions: Catastrophizing Pain
Interventions: DRUG: Midazolam and Fentanyl|BEHAVIORAL: Educational Reassurance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect Of Resuscitation Guided By Two Different Dynamic Parameters On Time To Normalization Of The Capillary Refill Time In Adult Patients With Septic Shock
Status: RECRUITING
Conditions: Septic Shock|Resuscitation
Interventions: DRUG: Group VTI|DRUG: Group IVC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of 0.2 % Digluconate Chlorhexidine Mouthwash for Preventing Alveolar Osteitis After Third Molar Extraction
Status: COMPLETED
Conditions: Alveolar Osteitis
Interventions: DRUG: DC071|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cognitive Training and Neuroplasticity in Mild Cognitive Impairment
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild Cognitive Impairment|Memory Disorders|Memory Impairment|Cognitive Impairment|Cognitive Disorder|Cognitive Decline
Interventions: OTHER: Computerized Cognitive Training|OTHER: Crossword Puzzles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Preoperative Counseling on Postoperative Opioid Use Following Knee Arthroscopy.
Status: COMPLETED
Conditions: Opioid Use|Opioid-use Disorder
Interventions: BEHAVIORAL: Opioid counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Proof of Concept Study of the Efficacy and Safety of Oral LAT8881 in Acute Migraine
Status: COMPLETED
Conditions: Acute Migraine
Interventions: DRUG: LAT8881|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Entire-body PET Scans for Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DIAGNOSTIC_TEST: Entire-body PET-CT scans|DRUG: Amyvid radiopharmaceutical
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetics of Biphasic Insulin Aspart 30 and 70 in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: biphasic insulin aspart 30|DRUG: biphasic insulin aspart 70
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Log2Lose: Incenting Weight Loss and Dietary Self-monitoring in Real-time to Improve Weight Management Among Adults With Obesity
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: BEHAVIORAL: Incentives for dietary self-monitoring and weight loss|BEHAVIORAL: Incentives for dietary self-monitoring|BEHAVIORAL: Incentives for weight loss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maintenance Treatment of Anemia in Pre-dialysis Subjects With Chronic Kidney Disease on Darbepoetin Treatment Versus BAY85-3934
Status: COMPLETED
Conditions: Anemia|Renal Insufficiency, Chronic
Interventions: DRUG: BAY85-3934|BIOLOGICAL: Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gender Stigma Consciousness and Surgical Training
Status: COMPLETED
Conditions: Gender Issues
Interventions: BEHAVIORAL: An article meant to trigger certain psychosocial behaviors|BEHAVIORAL: a neutral article
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Lung Function of Asthmatic Children by Nebulized MgSO4
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Magnesium Sulfate & albuterol|DRUG: albuterol|DRUG: magnesium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iloprost in Preventing Lung Cancer in Patients at High Risk for This Disease
Status: COMPLETED
Conditions: Lung Cancer|Precancerous Condition
Interventions: DRUG: iloprost|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Motility of Alloplastic Orbital Implants
Status: UNKNOWN
Conditions: Anophthalmos; Acquired|Evisceration; Traumatic, Eye
Interventions: PROCEDURE: Evisceration with orbital implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Tolerability of ABL501, and to Determine the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D) of ABL501 in Subjects With Any Progressive, Locally Advanced (Unresectable) or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumor
Interventions: DRUG: ABL501
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Positron Emission Tomography to Early Detect Frailty in Onco-geriatry
Status: COMPLETED
Conditions: Patients Over 75 Years Old With a Cancer Discovery
Interventions: RADIATION: Brain PET/CT step
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Sirolimus Plus CNI Compared With MMF Plus CNI in ABO-i Kidney Transplant Recipients.
Status: NOT_YET_RECRUITING
Conditions: Kidney Transplantation
Interventions: DRUG: Sirolimus Tab.|DRUG: Mycophenolate Mofetil Cap./Tab.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of add-on Canagliflozin in Patients With Type 2 Diabetes Treated With U-500 Insulin
Status: WITHDRAWN
Conditions: Diabetes, Obesity
Interventions: DRUG: Canagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thymus Transplantation With Immunosuppression
Status: COMPLETED
Conditions: DiGeorge Syndrome|DiGeorge Anomaly|Complete DiGeorge Anomaly|Complete DiGeorge Syndrome
Interventions: BIOLOGICAL: Thymus Tissue for Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The APPROACH Study: A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Patients With Familial Chylomicronemia Syndrome
Status: COMPLETED
Conditions: Familial Chylomicronemia Syndrome
Interventions: DRUG: Volanesorsen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PEP-CMV in Recurrent MEdulloblastoma/Malignant Glioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Medulloblastoma|Recurrent Brain Tumor, Childhood|Malignant Glioma
Interventions: DRUG: PEP-CMV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Evaluation of the Effect of Upfront Radiosurgery on Residual Growth Hormone-secreting Pituitary Adenoma
Status: UNKNOWN
Conditions: Acromegaly Due to Pituitary Adenoma
Interventions: RADIATION: Gamma knife radiosurgery|DRUG: Lanreotide 60Mg Solution for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Moderate Alcohol Consumption, Risk of Cardiovascular Disease and Type 2 Diabetes: Influence of Alcohol Oxidation
Status: COMPLETED
Conditions: Cardiovascular Disease|Type 2 Diabetes
Interventions: BEHAVIORAL: Alcohol: 25 gday (white wine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Piroxicam on Ovulation
Status: COMPLETED
Conditions: Contraception, Postcoital
Interventions: DRUG: Piroxicam ( BAYl1902)|DRUG: Piroxicam ( BAYl1902)|DRUG: Placebo|DRUG: Piroxicam ( BAYl1902)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Dosing Chart for Calculating the First Dose of Doxapram in Premature Infants
Status: COMPLETED
Conditions: Premature Infants|Apnea
Interventions: DRUG: Doxapram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation to Determine Safety of Taperloc Stems With BioGuard Coating When Used in Cementless Total Hip Arthroplasty
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis of Hip
Interventions: DEVICE: Bioguard Group|DEVICE: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: G-CSF in Patients With Anti-PD-1-axis Therapy-resistant Recurrent or Metastatic Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Granulocyte Colony-Stimulating Factor|PD-1 Inhibitor
Interventions: DRUG: PEG-rhG-CSF|DRUG: PEG-rhG-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Relation Between Midwifery Education and Listening to Classical Music With the Mode of Delivery
Status: UNKNOWN
Conditions: Delivery Mode|Pain Score|Breastfeeding Rate|Mental Health Issue|Apgar Score
Interventions: OTHER: Education|OTHER: No education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Improving the Approach to and Management of the Older Patient With Metastatic Gastric Cancer
Status: RECRUITING
Conditions: Metastatic Gastric Cancer
Interventions: BEHAVIORAL: Didactic Session|BEHAVIORAL: Comprehensive Geriatric Assessment, including an exploratory analysis to evaluate the use of fitness trackers for evaluation of functional status.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Optimization of fMRI for the Study of Basal Ganglia Activation in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DEVICE: MAGNETOM Avanto (MRI device)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: An Open-label, Randomized, Parallel-arm Study Investigating the Efficacy and Safety of Intravenous Administration of Pamrevlumab Versus Standard of Care in Patients With COVID-19
Status: COMPLETED
Conditions: COVID-19 Respiratory Infection|COVID-19 Pneumonia|Covid19
Interventions: DRUG: Pamrevlumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Three Dimensional Changes on Nasal Septum and Alveolar Cleft After Maxillary Expansion
Status: COMPLETED
Conditions: Nasal Septum; Deviation, Congenital|Cleft Lip and Palate|Maxillary Hypoplasia
Interventions: PROCEDURE: Maxillary Expansion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Rescuer Fatigue During Cardiopulmonary Resuscitation in Manikin by Using Personal Protective Equipment.
Status: COMPLETED
Conditions: Cardiac Arrest
Interventions: DEVICE: wearing level D personal protective equipment|DEVICE: wearing Level C personal protective equipment with N-95|DEVICE: wearing Level C personal protective equipment with Powered Air-Purifying Respiratory
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Teletherapy in Children Who Are Deaf and Hard of Hearing
Status: ACTIVE_NOT_RECRUITING
Conditions: Hearing Loss|Speech and Language Development Delay Due to Hearing Loss
Interventions: OTHER: Speech-Language Teletherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Effect of Multiple Doses of AZD5718 on Pharmacokinetics of Oral Midazolam in Healthy Subjects
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DRUG: Midazolam|DRUG: AZD5718
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: 40 Week Trial to Study the Safety of Asenapine When Added to Lithium or Valproate in the Treatment of Bipolar Disorder (A7501009)(P05786)
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Asenapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Age on the Absorption and Metabolism of Cocoa Flavanols
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Flavanol rich drink|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Carpal Arch Space Augmentation (CASA) Clinical Trial
Status: RECRUITING
Conditions: Carpal Tunnel Syndrome
Interventions: DEVICE: carpal arch space augmentation (CASA)|DEVICE: standard of care (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study for the Symptomatic Treatment of Chronic Idiopathic Urticaria
Status: COMPLETED
Conditions: Urticaria
Interventions: DRUG: Bilastine|DRUG: Levocetirizine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembro/Carbo/Taxol in Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Cancer|Endometrial Adenocarcinoma
Interventions: DRUG: Pembrolizumab|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: QUILT-3.018: Neukoplast™ (NK-92) for the Treatment of Refractory or Relapsed Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: Neukoplast™ (NK-92)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT)
Status: COMPLETED
Conditions: Arrhythmia|Cardiovascular Diseases|Death, Sudden, Cardiac|Heart Diseases|Heart Failure, Congestive|Heart Failure
Interventions: DRUG: amiodarone|DEVICE: defibrillators, implantable
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Trial to Learn How REGN5381 Works and How Safe it is in Adults With Heart Failure With Reduced Ejection Fraction (HFrEF)
Status: RECRUITING
Conditions: Heart Failure
Interventions: DRUG: REGN5381|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 2
Status: RECRUITING
Conditions: Heart Failure
Interventions: DRUG: LCZ 696|DRUG: Icatibant|DRUG: placebo|DRUG: Para-aminohippurate|DRUG: Iohexol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Parental Ratings of Quality of Life and Body Composition in 5-19 Year Olds While Participating in the Good NEWS 4 Kids Program
Status: UNKNOWN
Conditions: Quality of Life|Body Mass Index
Interventions: DIETARY_SUPPLEMENT: MannaBears|DIETARY_SUPPLEMENT: AlgaeCal Calcium|DIETARY_SUPPLEMENT: Calcium carbonate|DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Outcomes of Circuit Training and Low Carbohydrates Diet in the Young Obese Male in KSA
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: Circuit training exercise|DIETARY_SUPPLEMENT: Healthy high Fiber diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-inferiority Study of XM02 Filgrastim (Granix) and Filgrastim (Neupogen) in Combination With Plerixafor for Autologous Stem Cell Mobilization in Patients With Multiple Myeloma or Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Multiple Myeloma|Lymphoma, Non-Hodgkin
Interventions: DRUG: XM02 Filgrastim|DRUG: Filgrastim|PROCEDURE: Apheresis|DRUG: Plerixafor|PROCEDURE: Stem Cell Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Ibuprofen Sustained Release on Intraoperative and Postoperative Pain in Mandibular Molars
Status: UNKNOWN
Conditions: Anesthesia
Interventions: DRUG: Brufen Retard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative (Pre-amputation) Cryoanalgesia to Improve Post-amputation Phantom Limb Pain
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: DEVICE: Cryoanalgesia|DEVICE: Sham Cryoanalgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Understanding the Effects of Transauricular Vagus Nerve Stimulationon on Neural Networks and Autonomic Nervous System
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DEVICE: Transauricular vagus nerve stimulation (taVNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Noninvasive Positive Pressure Ventilation During Neonatal Nasal Intubation
Status: RECRUITING
Conditions: Infant, Newborn, Diseases|Intubation Complication
Interventions: PROCEDURE: Intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Decision Support System to Evaluate VENTilation in ARDS
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome
Interventions: DEVICE: Beacon Caresystem device with advice|DEVICE: Beacon Caresystem device without advice activated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: SAP Block to Reduce Post Mastectomy Pain
Status: COMPLETED
Conditions: Serratus Anterior Plain Block
Interventions: DRUG: Magnesium Sulphate|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of a Multi-Antigen Therapeutic Vaccine in Patients With Metastatic Melanoma
Status: TERMINATED
Conditions: Melanoma|Cancer
Interventions: BIOLOGICAL: ALVAC(2) Melanoma multi-antigen therapeutic vaccine|BIOLOGICAL: Intron A, Interferon alpha -2b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Umbilical-Cord-Derived Mesenchymal Stem Cells Injection for Chronic Radiation Proctitis
Status: RECRUITING
Conditions: Chronic Radiation Proctitis
Interventions: BIOLOGICAL: Mesenchymal Stem Cells (MSCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Hyperbaric Oxygen Treatments to Reduce Complications in Diabetic Patients Undergoing Vascular Surgery
Status: WITHDRAWN
Conditions: Diabetes|Peripheral Arterial Disease|Arterial Occlusive Disease
Interventions: PROCEDURE: Hyperbaric Oxygen treatment (HBO)|PROCEDURE: Sham HBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation (rTMS) in Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: rTMS + Neuronavigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of TORasemide oN hemodynAmic and Neurohormonal Stress, and carDiac remOdeling in Heart Failure
Status: UNKNOWN
Conditions: Heart Failure
Interventions: DRUG: Furosemide|DRUG: Torasemide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: FRALYSE Trial: Comparison of the Classical Rt-PA Procedure With a Longer Procedure in Acute Ischemic Stroke
Status: TERMINATED
Conditions: Stroke, Acute
Interventions: DRUG: DFIL|DRUG: NINDS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Adipose Tissue Storage in the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery
Status: RECRUITING
Conditions: Diabetes Mellitus Type 2
Interventions: PROCEDURE: Bariatric surgery|DRUG: Nicotinic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Live Recombinant Newcastle Disease Virus-vectored COVID-19 Vaccine Phase 1 Study.
Status: ACTIVE_NOT_RECRUITING
Conditions: SARS-CoV-2
Interventions: DRUG: Sodium Chloride|BIOLOGICAL: NDV-HXP-S IN low dose|BIOLOGICAL: NDV-HXP-S IM low dose|BIOLOGICAL: NDV-HXP-S IN high dose|BIOLOGICAL: NDV-HXP-S IM high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Losartan for Patients With COVID-19 Requiring Hospitalization
Status: COMPLETED
Conditions: Corona Virus Infection|Acute Respiratory Distress Syndrome|SARS-CoV Infection
Interventions: DRUG: Losartan|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: THIODERM STRONG Compared to Juvéderm® VOLUMA® Lidocaine for the Treatment of Midface Volume Deficit
Status: COMPLETED
Conditions: Mid Face Volume Deficit
Interventions: DEVICE: Thioderm Strong|DEVICE: Juvéderm VOLUMA Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Supplementation of Eriocitrin in Intestinal Microbiota
Status: TERMINATED
Conditions: Pre Diabetes
Interventions: DIETARY_SUPPLEMENT: Eriocitrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Y90 Radioembolization Dose Delivery and Radiation Exposure Assessment
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Radiation Exposure
Interventions: DIAGNOSTIC_TEST: Post therapy PET/CT Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Assessing the Safety and Efficacy of a Novel Microneedling and Laser Device for Male Pattern Hair Loss
Status: RECRUITING
Conditions: Male Pattern Baldness|Androgenetic Alopecia|Hair Loss/Baldness|Hair Loss|Pattern Baldness
Interventions: DEVICE: SAGA-001 (A)|DEVICE: SAGA-001 (B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Proton Pump Inhibitor Prevent Dual Antiplatelet Agents Induced Gastrointestinal Ulcer After Coronary Artery Bypass Graft
Status: WITHDRAWN
Conditions: Gastric Ulcer Induced by Antiplatelet Agent|Ulcer of the Gastrointestinal Tract|Proton Pump Inhibitor
Interventions: DRUG: Pantoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Bright Light Therapy on Fatigue, Sleep and Circadian Activity Rhythms in Lung Cancer Survivors
Status: UNKNOWN
Conditions: Fatigue|Sleep Disturbance|Circadian Dysregulation
Interventions: DEVICE: Morning bright light therapy|DEVICE: Dim light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: TALL-104 and Gleevec in Chronic Myelogenous Leukemia Patients
Status: TERMINATED
Conditions: Chronic Myelogenous Leukemia
Interventions: DRUG: Imatinib Mesylate (IM)|DRUG: TALL-104 cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Penpulimab Combined With Anlotinib in Neoadjuvant Treatment of Resectable Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: NSCLC
Interventions: DRUG: penpulimab combined with anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Effectiveness of Collagen Cross-Linking at an Irradiance of 9 mW/cm2 and 18 mW/cm2
Status: UNKNOWN
Conditions: Keratoconus|Corneal Ectasia
Interventions: DRUG: Riboflavin 0.1% ophthalmic solution|DEVICE: CCL-VARIO UV lamp|DEVICE: CCL-VARIO at 18 mW/cm2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Intraovarian Platelet Rich Plasma in Women With Poor Ovarian Response and Premature Ovarian Insufficiency
Status: COMPLETED
Conditions: Premature Ovarian Failure|Diminished Ovarian Reserve
Interventions: BIOLOGICAL: PRP injection into at least one ovary
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of GCSF Therapy to Treat Patients at High Risk for Chemotherapy Induced Severe Neutropenia
Status: COMPLETED
Conditions: Breast Cancer|Neutropenia
Interventions: DRUG: AVI-014 versus Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of HIV-1 Vaccines C62-M4 or C1C62-M3m4 in Persons With HIV-1 Suppressed on ART
Status: RECRUITING
Conditions: HIV Vaccine|HIV-1-infection
Interventions: BIOLOGICAL: C62|BIOLOGICAL: C1C62|OTHER: Placebo|BIOLOGICAL: M4|BIOLOGICAL: M3M4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety and Efficacy of Brimonidine Tartrate Ophthalmic Solution in Adult and Geriatric Subjects
Status: COMPLETED
Conditions: Ocular Redness
Interventions: DRUG: Placebo|DRUG: Brimonidine tartrate 0.025%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Skin Biopsies and DNA Analysis in Patients Receiving Irinotecan or Gemcitabine For Advanced Solid Tumors
Status: COMPLETED
Conditions: Breast Cancer|Colorectal Cancer|Pancreatic Cancer
Interventions: OTHER: biologic sample preservation procedure|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|PROCEDURE: biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Community Acquired Pneumonia: Outcome, Quality of Life and Immune Status
Status: COMPLETED
Conditions: Pneumonia|Streptococcus Pneumoniae|Immune Response
Interventions: BIOLOGICAL: Prevnar 13
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Autoantibody Reduction Therapy in Patients With Idiopathic Pulmonary Fibrosis
Status: COMPLETED
Conditions: Ambulatory IPF
Interventions: DRUG: Rituximab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Stenting of Gastrointestinal Cancer
Status: COMPLETED
Conditions: Gastrointestinal Neoplasms|Biliary Tract Neoplasms
Interventions: PROCEDURE: Endoscopic stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regional Anesthesia for Major Surgery of the Foot. Levobupivacaïne Ropivacaine 0.5% Versus 0.5% in the Sciatic Block Through médiofémorale
Status: TERMINATED
Conditions: Nerve Block
Interventions: DRUG: levobupivacaïne 0,5 %|DRUG: ropivacaïne 0,5 %
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2b Randomized Controlled Study of Tecemotide (L-BLP25) for Immunotherapy of NSCLC (Non-Small Cell Lung Cancer)
Status: COMPLETED
Conditions: Lung Neoplasms|Carcinoma, Non-Small-Cell Lung
Interventions: BIOLOGICAL: Tecemotide (L-BLP25)|DRUG: Single low dose cyclophosphamide|OTHER: Best Supportive Care (BSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-Dose (17.5 mg/Day) Acitretin: Comparable Efficacy Without the Side Effects?
Status: UNKNOWN
Conditions: Psoriasis
Interventions: DRUG: Acitretin 17.5 mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Follow up of Patients With Aortic Aneurysm by Dosage of Circulant Endothelial Progenitor Cells
Status: UNKNOWN
Conditions: Thoracic or Abdominal Aortic Aneurysm With no Indication for Surgical Treatment
Interventions: BIOLOGICAL: blood taking
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Effects of a Single and Multiple Oral Doses of GLPG3121 in Adult, Healthy, Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG3121 SAD|DRUG: Placebo SAD|DRUG: GLPG3121 MAD|DRUG: Placebo MAD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Spinal Cord Stimulation in the Treatment of Chronic, Intractable Pain Using the Nalu™ Neurostimulation System
Status: COMPLETED
Conditions: Pain, Chronic|Pain, Intractable|Pain, Back
Interventions: DEVICE: Nalu Neurostimulation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Tadalafil for the Treatment of Diabetic Patients With Symptoms of Upset Stomach and Delayed Stomach Emptying
Status: COMPLETED
Conditions: Gastroparesis
Interventions: DRUG: tadalafil|DRUG: tadalafil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endometrial Scratching Prior to Controlled Ovarian Stimulation (COH) in Women Undergoing In-vitro Fertilization With Previous IVF Failure
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: scratching|PROCEDURE: A PLACEBO PROCEDURE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine for Intraoperative Shivering in Scheduled Elective Cesarean Delivery
Status: RECRUITING
Conditions: Shivering|Dose Finding Study
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery
Status: RECRUITING
Conditions: Postoperative Delirium|Postoperative Cognitive Dysfunction|Thoracic Aortic Aneurysm
Interventions: DIAGNOSTIC_TEST: Trajectory of neuroinflammatory proteins in CSF and blood
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pilot Study of Vaccination With Epitope-Enhanced TARP Peptide and TARP Peptide-Pulsed Dendritic Cells in the Treatment of Stage D0 Prostate Cancer
Status: COMPLETED
Conditions: Prostate Specific Antigens|Prostate Neoplasms
Interventions: BIOLOGICAL: T-cell receptor alternate reading frame protein (TARP) peptide vaccine|BIOLOGICAL: T-cell receptor alternate reading frame protein (TARP) dendritic cell vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Versus Propofol for Prolonged Sedation in Poly Traumatized Mechanically Ventilated Patients
Status: COMPLETED
Conditions: Trauma
Interventions: DRUG: Dexmedetomidine|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Doxepin and Nortriptyline on Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Doxepin|DRUG: Nortriptyline|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Safety, and Efficacy of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate Single Tablet Regimen (STR) in Adolescents
Status: COMPLETED
Conditions: Acquired Immunodeficiency Syndrome|HIV Infections
Interventions: DRUG: EVG/COBI/FTC/TDF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Aripiprazole in Patients With Schizophrenia in General Psychiatric Practices
Status: COMPLETED
Conditions: Schizophrenia and Schizoaffective Disorder
Interventions: DRUG: Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: The Comparison Between Ringer Lactate Solution and Normal Saline in Post-Operative Period of Kidney Transplantation
Status: NOT_YET_RECRUITING
Conditions: Electrolyte Imbalance|Kidney Transplant; Complications
Interventions: DRUG: Ringer's Lactate Crystalloid Solutions|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of High-Dose Vitamin D3 in Smokers and Non-Smokers With and Without HIV
Status: TERMINATED
Conditions: HIV/AIDS|Vitamin D Deficiency|Smoker Lung
Interventions: DRUG: Vitamin D3 450,000 IU orally
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study Evaluating Safety and Efficacy of OTX-TP in Subjects With OAG or OHT
Status: COMPLETED
Conditions: Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Travoprost|OTHER: Placebo Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of T-817MA in Patients With Mild to Moderate Alzheimer's Disease (US202)
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: T-817MA-H|DRUG: T-817MA-L|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Simplified Treat And Extend Regimen Using Ranibizumab in Exudative Age Related Macular Degeneration
Status: UNKNOWN
Conditions: Exudative Age-related Macular Degeneration
Interventions: DRUG: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Amoxicillin Versus Placebo on Gastrointestinal Motility in Children
Status: COMPLETED
Conditions: Functional Gastrointestinal Disorders
Interventions: DRUG: Amoxicillin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment Resistant Depression (Pilot)
Status: COMPLETED
Conditions: Depressive Disorder, Treatment-Resistant
Interventions: DRUG: Ketamine|DRUG: Clonidine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TriMaster: Study of a DPP4 Inhibitor, SGLT2 Inhibitor and Thiazolidinedione as Third Line Therapy in Patients With Type 2 Diabetes.
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Sitagliptin - DPP4i|DRUG: Canagliflozin - SGLT2i|DRUG: Pioglitazone - TZD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: REsPonse to Interferon-Alpha in InterfeRon-β Neutralizing Antibody Positive Multiple Sclerosis Patients
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Interferon-beta and human leukocyte Interferon-α
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Montelukast in Bronchiolitis Obliterans Syndrome
Status: COMPLETED
Conditions: Bronchiolitis Obliterans|Lung Transplantation|Graft Rejection
Interventions: DRUG: Montelukast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Whole-Brain Radiation Therapy With or Without Hippocampal Avoidance in Limited Stage or Extensive Stage Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Extensive Stage Small Cell Lung Carcinoma|Limited Stage Small Cell Lung Carcinoma
Interventions: RADIATION: Three-Dimensional Conformal Radiation Therapy|RADIATION: Intensity-Modulated Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Concurrent Treatment for Patients With Cervical Radiculopathy
Status: UNKNOWN
Conditions: Spinal Nerve Root Disorder Nos
Interventions: OTHER: concurrent traction and neuromobilization technique|OTHER: sequential traction and neuromobilization technique|OTHER: active exercise program|OTHER: manual therapy to cervical and thoracic spine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Dex-Methylphenidate Extended Release 30 mg Versus 20 mg in Children (6-12 Years) With Attention-Deficit/Hyperactivity Disorder (ADHD) in a Laboratory Classroom Setting.
Status: COMPLETED
Conditions: Attention-Deficit/Hyperactivity Disorder (ADHD)
Interventions: DRUG: Dex-Methylphenidate hydrochloride Extended Release (Focalin® XR)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Behavioral Preschool Teacher Training for Externalizing
Status: COMPLETED
Conditions: Attention Deficit and Disruptive Behavior Disorders|Problem Behavior|Attention Deficit Disorder With Hyperactivity
Interventions: BEHAVIORAL: Comet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Efficacy of the Redy™ Renal Denervation System in the Treatment of Patients With Uncontrolled Hypertension
Status: UNKNOWN
Conditions: Hypertension Resistant to Conventional Therapy
Interventions: DEVICE: Redy™ Renal Denervation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Doxycycline for the Treatment of Cutaneous T-Cell Lymphoma
Status: TERMINATED
Conditions: Cutaneous T-cell Lymphoma|Mycosis Fungoides|Sezary Syndrome
Interventions: DRUG: Doxycycline monohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Upper Airway Ultrasound Training Requirements
Status: COMPLETED
Conditions: Airway Management
Interventions: OTHER: Visualization of the hyoid bone|OTHER: Visualization of vocal cords|OTHER: Localization of thyrohyoid membrane|OTHER: Visualization of epiglottis and pre-epiglottic space|OTHER: Visualization of cricothyroid membrane|OTHER: Visualization of thyroid gland|OTHER: Hyoid bone to skin distance|OTHER: Anterior commissure to skin distance|OTHER: Epiglottis to skin distance|OTHER: Thyroid isthmus to skin distance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Application of 68Ga-FAPI PET Imaging in Detection of Ovarian Cancer Recurrence
Status: RECRUITING
Conditions: 68Ga-FAPI|Ovarian Cancer|Epithelial Ovarian Cancer|Positron Emission Tomography
Interventions: DIAGNOSTIC_TEST: 68Ga-FAPI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial to Evaluate the Safety and Efficacy of MONOFIX® PGCL Suture in Laparoscopic Surgery
Status: RECRUITING
Conditions: Laparoscopic Hysterectomy
Interventions: DEVICE: MONOFIX® PGCL|DEVICE: Quill Monoderm™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Neoadjuvant Androgen Deprivation, Darolutamide, and Ipatasertib in Men With Localized, High Risk Prostate Cancer
Status: TERMINATED
Conditions: Castrate Resistant Prostate Cancer
Interventions: DRUG: Ipatasertib|DRUG: Darolutamide|DRUG: Androgen Deprivation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT