pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Chemoprophylaxis of SARS-CoV-2 Infection (COVID-19) in Exposed Healthcare Workers
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Hydroxychloroquine|DRUG: Placebo of Hydroxychloroquine|DRUG: Lopinavir and ritonavir|DRUG: Placebo of LPV/r Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of N-acetylcysteine With or Without Steroids in Drug Induced Liver Injury
Status: TERMINATED
Conditions: Drug Induced Liver Injury
Interventions: DRUG: Prednisolone|DRUG: N-Acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Effects of RIPC in Patients After Total Arch Replacement
Status: COMPLETED
Conditions: Acute Kidney Injury|Dialysis
Interventions: OTHER: remote ischemic preconditioning|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Effect of Two Preventive Exercise Programs for Swimmer's Shoulder on the Torque of Shoulder Rotator Muscles in Competitive Swimmers
Status: COMPLETED
Conditions: Shoulder Pain|Injury;Sports|Sports Physical Therapy
Interventions: OTHER: 12-weeks weight prevention program|OTHER: 12-weeks elastic band prevention program|OTHER: sham intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: NOrth American Study for the Treatment of Recurrent epIstaxis With DoxycycLine: The NOSTRIL Trial
Status: COMPLETED
Conditions: Epistaxis
Interventions: DRUG: Doxycycline|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: fNIRS Neurofeedback Training Using Virtual Reality in Children With ADHD
Status: RECRUITING
Conditions: ADHD
Interventions: BEHAVIORAL: fNIRS Neurofeedback-VR Training|BEHAVIORAL: Computerized Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Thinking in Fibromyalgia
Status: COMPLETED
Conditions: Rumination|Fibromyalgia|Chronic Pain|Repetitive Negative Thinking
Interventions: OTHER: rumination induction|OTHER: distraction induction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treating Heel Pain in Adults: A Randomized Clinical Trial of Hard Versus Soft Orthotics
Status: COMPLETED
Conditions: Heel Pain Syndrome
Interventions: DEVICE: Custom heel pads and modified soft molded orthotics|DEVICE: Custom hard orthotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti Reflux Mucosal Ablation Therapy in PPI Dependent GERD
Status: RECRUITING
Conditions: Gastroesophageal Reflux
Interventions: PROCEDURE: Anti reflux mucosal ablation (ARMA)|PROCEDURE: Sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Evaluation of a Novel Nasal Pillows Mask for the Treatment of Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Nasal Pillows CPAP mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effect of Quizartinib on the Pharmacokinetics of the P-gp Substrate Dabigatran Etexilate in Healthy Participants
Status: COMPLETED
Conditions: Healthy Subjects|Drug-drug Interaction|Pharmacokinetics|Quizartinib
Interventions: DRUG: Dabigatran Etexilate Mesylate|DRUG: Quizartinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Trilaciclib Combined With Chemotherapy in the Treatment of Diffuse Large B-Cell Lymphoma Patients
Status: RECRUITING
Conditions: DLBCL
Interventions: DRUG: Trilaciclib+R-CHOP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Melatonin Treatment for Induced Transient Insomnia
Status: COMPLETED
Conditions: Delayed Sleep Phase Disorder|Jet-lag|Shift-work Disorder
Interventions: BIOLOGICAL: Low Dose Melatonin|BIOLOGICAL: Placebo|BIOLOGICAL: High Dose Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation on the Effectiveness and Safety of RuiXin-CoronaryAI for Diagnosis of Coronary Artery Stenosis
Status: UNKNOWN
Conditions: Coronary Artery Disease|Artificial Intelligence|Coronary Artery Stenosis|CT Angiography
Interventions: DEVICE: RuiXin-CoronaryAI software
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery
Status: COMPLETED
Conditions: Foot and Ankle Procedures
Interventions: DRUG: Dexamethasone|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetic Study Comparing Salmeterol/Fluticasone Easyhaler Products and Seretide Diskus
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Salmeterol/fluticasone Easyhaler|DRUG: Salmeterol/fluticasone Easyhaler with charcoal|DRUG: Seretide Diskus|DRUG: Seretide Diskus with charcoal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Nitric Oxide for Pulmonary Hypertension and Bronchopulmonary Dysplasia
Status: TERMINATED
Conditions: Pulmonary Hypertension|Bronchopulmonary Dysplasia
Interventions: DRUG: inhaled nitric oxide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Oral Ixazomib in Combination With Melphalan and Prednisone in Participants With Newly Diagnosed Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Ixazomib|DRUG: Melphalan|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of GLP-1 Analogues on Fluid Intake in Patients With Primary Polydipsia (The GOLD-Study)
Status: COMPLETED
Conditions: Primary Polydipsia
Interventions: DRUG: Dulaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Cerebral-Respiratory Interaction in Controlled Mechanically Ventilated Neurosurgical Patients. (The CeRes-CMV Study)
Status: UNKNOWN
Conditions: Mechanical Ventilation Complication|Neurological Disorder|Lung Injury
Interventions: OTHER: Mechanically ventilated neurosurgical patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Added Value of a Third Supervised Training Session to a Standard 12-week Rehabilitation Program After Breast Cancer: Pilot Study
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: standard 12-week rehabilitation program|OTHER: extra session hydrotherapy|OTHER: extra session ground exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Vitamin D on Lipids
Status: COMPLETED
Conditions: Hypercholesterolemia|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D (1000 or 2000 IU/day)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Assessment of Energy Balance
Status: COMPLETED
Conditions: Caloric Intake and Energy Metabolism
Interventions: BEHAVIORAL: Digital Photography of Foods|OTHER: doubly labeled water|DEVICE: IDEEA|BEHAVIORAL: low-calorie diet|DEVICE: Actical|DEVICE: Sensewear Armband
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose-Ranging Study of the Effect of Glycopyrrolate in Subjects With Axillary Hyperhidrosis
Status: COMPLETED
Conditions: Hyperhidrosis
Interventions: DRUG: glycopyrrolate, 1.0%|DRUG: glycopyrrolate, 2.0%|DRUG: glycopyrrolate, 3.0%|DRUG: glycopyrrolate, 4.0%|OTHER: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Nivolumab + Ipilimumab in Advanced HCC Patients Who Have Progressed on First Line Atezolizumab + Bevacizumab
Status: RECRUITING
Conditions: BCLC Stage B Hepatocellular Carcinoma|BCLC Stage C Hepatocellular Carcinoma|Locally Advanced Hepatocellular Carcinoma|Metastatic Hepatocellular Carcinoma|Stage III Hepatocellular Carcinoma AJCC v8|Stage IIIA Hepatocellular Carcinoma AJCC v8|Stage IIIB Hepatocellular Carcinoma AJCC v8|Stage IV Hepatocellular Carcinoma AJCC v8|Stage IVA Hepatocellular Carcinoma AJCC v8|Stage IVB Hepatocellular Carcinoma AJCC v8|Unresectable Hepatocellular Carcinoma
Interventions: BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Predictive Value of 18F-fluorodeoxyglucose Positron Emission Tomography and Brain Perfusion Computed Tomography for the Efficacy of Anti-angiogenic Therapy (Bevacizumab) in Recurrent Glioblastoma
Status: UNKNOWN
Conditions: Glioblastoma
Interventions: OTHER: FDG PET|OTHER: CT scan|OTHER: Magnetic resonance imaging (MRI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of PCI-32765 (BTK Inhibitor) in Combination With Carfilzomib in Relapse/Refractory Mantle Cell Lymphoma
Status: TERMINATED
Conditions: Lymphoma
Interventions: DRUG: Ibrutinib|DRUG: Carfilzomib|BEHAVIORAL: Phone Calls
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tricalcium Phosphate and Chitosan as Bone Regenerator Versus Autologous Graft in Surgery for Mandibular Fracture
Status: COMPLETED
Conditions: Mandibular Fractures
Interventions: PROCEDURE: Tricalcium Phosphate / Chitosan|PROCEDURE: Autologous Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression
Status: COMPLETED
Conditions: Treatment-resistant Depression
Interventions: DRUG: Esketamine|DRUG: Placebo|DRUG: Duloxetine (Oral Antidepressant)|DRUG: Escitalopram (Oral antidepressant)|DRUG: Sertraline (Oral Antidepressant)|DRUG: Venlafaxine Extended Release (XR) (Oral Antidepressant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Doxorubicin and Carboplatin in Treating Patients With Recurrent Ovarian Cancer
Status: WITHDRAWN
Conditions: Ovarian Cancer
Interventions: DRUG: carboplatin|DRUG: doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Galactose in Children With Steroid Resistant Nephrotic Syndrome
Status: COMPLETED
Conditions: Focal Segmental Glomerulosclerosis|Steroid Resistant Nephrotic Syndrome
Interventions: DRUG: D-Galactose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REsistance to Aspirin and Clopidogrel in acuTe Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Aspirin 200mg qd, Clopidogrel 2x75mg qd
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mode of Action (MoA) Study of TOTUM-63 in Individuals at Increased Cardio-metabolic Risk
Status: COMPLETED
Conditions: Prediabetic State|Dysglycemia|Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: TOTUM-63
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Postural Control and Trunk Neuromuscular Activation in Athletes With Chronic Low Back Pain
Status: COMPLETED
Conditions: Athletic Injury|Low Back Pain
Interventions: OTHER: G1: exercises for lumbar stabilization|OTHER: G2: back strengthening exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Miswak Efficacy Compared With Chlorhexidine
Status: COMPLETED
Conditions: Gingivitis
Interventions: DRUG: Miswak mouthwash group|DEVICE: Chlorhexidine gluconate mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2
Status: COMPLETED
Conditions: Familial Hemiplegic Migraine Type 1 and 2|Healthy Volunteers
Interventions: DRUG: GTN
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: ECT
Clinical trial: Safety Study of Intracranial Support Catheter and Guide Catheter for Stent-Assisted Embolization in the Treatment of Intracranial Aneurysms
Status: UNKNOWN
Conditions: Intracranial Aneurysm
Interventions: DEVICE: Intracranial Support Catheter|DEVICE: Guide Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BETAmethasone Dose Reduction: Non-Inferiority on the Neurocognitive Outcomes of Children Born Before 32 Weeks of Gestation
Status: RECRUITING
Conditions: Premature Childbirth
Interventions: OTHER: neurodevelopmental assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Characterization of Tuberculosis Associated Lung Fibrosis and Respiratory Impairment, and Prevention Using Doxycycline
Status: NOT_YET_RECRUITING
Conditions: Tuberculosis, Pulmonary
Interventions: DRUG: Doxycycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Eicosapentaenoic Acid (EPA) in Patients With Cancer Cachexia
Status: COMPLETED
Conditions: Cancer Cachexia
Interventions: DRUG: Eicosapentaenoic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of GSK Biologicals' (Pre-) Pandemic Influenza Candidate Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza A (H5N1) Virus Monovalent Vaccine, Adjuvanted
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vegetable Ivory Bone Material in Bone Healing Compared to Current Standard Methods of Bone Healing
Status: NOT_YET_RECRUITING
Conditions: Bone Volume
Interventions: PROCEDURE: Bone Grafting|OTHER: Vegetable Derived
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Evaluation of the CARTO™ XP EP Navigation System v9 and Biosense Webster SOUNDSTAR 3D Diagnostic Ultrasound. A Feasibility Study
Status: WITHDRAWN
Conditions: Cardiac Arrhythmias
Interventions: PROCEDURE: Electrophysiology|DEVICE: CARTO™ XP EP Navigation System V9
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cebranopadol Effects on Ventilatory Drive, Central Nervous System (CNS) and Pain.
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Cebranopadol 600 µg|DRUG: Cebranopadol 800 µg|DRUG: Cebranopadol 1000 µg|DRUG: Oxycodone 30 mg|DRUG: Oxycodone 60 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Effects of Topical Clitoral Estradiol Cream in Post Menopausal Women
Status: COMPLETED
Conditions: Hypoactive Sexual Desire Disorder
Interventions: OTHER: Placebo vulvar cream|OTHER: Estradiol vulvar cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety Study of MP4CO in Adult Sickle Cell Patients
Status: COMPLETED
Conditions: Anemia, Sickle Cell|Sickle Cell Anemia|Sickle Cell Disease|Sickle Cell Disorders|Hemoglobin SC Disease|Sickle Cell Hemoglobin C Disease
Interventions: DRUG: MP4CO|DRUG: Sodium chloride solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Simultaneous Care in Recurrent and/or Metastatic Head and Neck Cancer: the SupCare Study
Status: NOT_YET_RECRUITING
Conditions: Head and Neck Neoplasms
Interventions: PROCEDURE: Early palliative care, integrated with the standard oncologic care (proactive approach)|PROCEDURE: Palliative care requested as needed, integrated with the standard oncologic care (reactive approach)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Changes of Optic Nerve Sheath Diameter Between Obese and Non-obese Patients Undergoing Laparoscopic Gynecological Surgery
Status: COMPLETED
Conditions: Optic Nerve Sheath Diameter
Interventions: OTHER: Ultrasound assessment of optic nerve sheath diameter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Explore the Mechanism of Action of Ocrelizumab and B-Cell Biology in Participants With Relapsing Multiple Sclerosis (RMS) or Primary Progressive Multiple Sclerosis (PPMS)
Status: COMPLETED
Conditions: Relapsing Multiple Sclerorsis|Multiple Sclerosis, Primary Progressive
Interventions: DRUG: Ocrelizumab|PROCEDURE: Lumbar Puncture|DRUG: Methyloprednisolone|DRUG: Antihistamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Litx™ System Combined With Chemotherapy in Patients With Colorectal Liver Metastases
Status: COMPLETED
Conditions: Liver Metastasis|Colorectal Neoplasms|Liver Neoplasms|Neoplasm Metastasis
Interventions: DRUG: Talaporfin sodium (LS11)|DEVICE: LED-based light infusion device|DEVICE: Light emitting diodes (LED)|PROCEDURE: Photodynamic therapy|PROCEDURE: Phototherapy|PROCEDURE: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Human Monoclonal Antibody Against Staphylococcus Aureus Alpha Toxin in Mechanically Ventilated Adult Subjects - 2
Status: RECRUITING
Conditions: Ventilator Associated Pneumonia|Staphylococcus Aureus
Interventions: BIOLOGICAL: Suvratoxumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hippocampal-Sparing Stereotactic Radiosurgery Treatment of Brain Metastases Using CyberKnife
Status: NOT_YET_RECRUITING
Conditions: Brain Metastases|Radiosurgery
Interventions: RADIATION: Hippocampal-sparing|RADIATION: Stereotactic radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AAVRh.10 Administered to Children With Late Infantile Neuronal Ceroid Lipofuscinosis
Status: COMPLETED
Conditions: Late Infantile Neuronal Ceroid Lipofuscinosis|Batten Disease
Interventions: BIOLOGICAL: AAVrh.10CUCLN2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measuring Cell Free DNA During the Course of Treatment for Esophageal Cancer as a Marker of Response and Recurrence
Status: TERMINATED
Conditions: Esophageal Neoplasm|Esophageal Neoplasms Malignancy Unspecified|Esophageal Neoplasms Malignant|Cancer of Esophagus|Cancer of the Esophagus|Esophageal Cancer|Esophagus Cancer|Neoplasm, Esophageal
Interventions: OTHER: Blood and Tissue Collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Oral Care to Prevent Oral Mucositis in ER Positive MBC Patients Treated With Everolimus: Phase 3 RCT
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: Oral management|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantification of Exhaled Particles to Identify Airborne Transmission Risks of COVID-19
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Community Mask|OTHER: Surgical Mask|OTHER: FFP2 respirator|OTHER: FFP3 respirator
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Flexible Individualized ExeRcise Programme for Cancer Patients During ChEmotherapy
Status: NOT_YET_RECRUITING
Conditions: Cancer
Interventions: BEHAVIORAL: Exercise|BEHAVIORAL: Health Behaviour Change (Pedometer)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomised Trial of Artekin and Artesunate & Amodiaquine for Uncomplicated Malaria in Timika, Papua, Indonesia.
Status: COMPLETED
Conditions: Malaria, Falciparum|Malaria, Vivax
Interventions: DRUG: Amodiaquine plus artesunate; Artekin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermediate Cervical Block Under Ultrasound for Thyroid Surgery: Impact on Per and Postoperative Opioid Consumption
Status: COMPLETED
Conditions: Local Anesthesia|Analgesia Disorder
Interventions: PROCEDURE: bilateral cervical plexus block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Novel Biomarkers of AKI (Acute Kidney Injury) in Post-operative Patients
Status: TERMINATED
Conditions: Acute Kidney Injury|Arterial Hypertension|Obesity|Cardio Vascular Disease|Diabetes Mellitus|Chronic Liver Disease|Hypercholesterolemia
Interventions: DEVICE: Nephro Check Test|OTHER: serum creatinine measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Acute EpiDural Hematoma Treated With Middle Meningeal Artery Embolization: a Randomized Trial (AEDH-MT)
Status: NOT_YET_RECRUITING
Conditions: EpiDural Hematoma|Traumatic Brain Injury
Interventions: PROCEDURE: MMA embolization plus medical therapy|DRUG: Medical therapy alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of DLBS1033 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: DLBS1033|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Evaluation of the Safety and Effectiveness of ANIMERS Chiara LA and JUVÉDERM VOLUMA® for Aging Mid-Face
Status: COMPLETED
Conditions: Dermal Filler|Hyaluronic Acid|Lidocaine|Aging Mid-Face
Interventions: DEVICE: ANIMERS Chiara LA|DEVICE: JUVÉDERM VOLUMA®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Needle Manipulation and Accuracy Between Hand Held Automatic and Traditional Ultrasound Device
Status: NOT_YET_RECRUITING
Conditions: Labor Analgesia
Interventions: DEVICE: Traditional ultrasound|DEVICE: Automated ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Postoperative Pain and PTN and Reciproc
Status: COMPLETED
Conditions: Apical Periodontitis|Dental Pulp Necrosis
Interventions: PROCEDURE: Reciprocating single-file system|PROCEDURE: Rotational multi-file system.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Parametric Testing of Direct Physiological Effects of Transcutaneous Vagus Nerve Stimulation (tVNS) in Healthy Controls
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Digitmer High Voltage Stimulator model DS7A TENS unit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Compromised Microcirculation in Women With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: ganirelix acetate|DRUG: methyl testosterone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Nal-IRI With 5-FU, Levofolinic Acid and Oxaliplatin in Patients With Resectable Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Adenocarcinoma
Interventions: DRUG: Irinotecan Liposomal Injection [Onivyde]; oxaliplatin, 5-FU; Levofolinic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of LifeSeal™ Kit for Colorectal Staple Line Sealing
Status: UNKNOWN
Conditions: Rectal Cancer|Anastomotic Leak
Interventions: DEVICE: LifeSeal™ Kit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Doxorubicin in Treating Patients With AIDS-Related Kaposi's Sarcoma
Status: COMPLETED
Conditions: Sarcoma
Interventions: DRUG: daunorubicin hydrochloride|DRUG: pegylated liposomal doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Allopregnanolone in Chronic Complex Traumatic Brain Injury
Status: NOT_YET_RECRUITING
Conditions: Traumatic Brain Injury (TBI)
Interventions: DRUG: Placebo|DRUG: Allopregnanolone|DRUG: Allopregnanolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ketamine HCl Prolonged Release Oral Tablets for CRPS
Status: NOT_YET_RECRUITING
Conditions: Complex Regional Pain Syndromes
Interventions: DRUG: 80mg Ketamine HCl Prolonged Release|DRUG: 160mg Ketamine HCl Prolonged Release|DRUG: Administration of Ketamine HCl Prolonged Release - 240mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Trial of Afatinib (BIBW 2992) and Dasatinib in Non-small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Lung Cancer|Non-small Cell Lung Cancer (NSCLC)
Interventions: DRUG: Dasatinib - 1A|DRUG: Afatinib - 1A|DRUG: Dasatinib - 1B|DRUG: Afatinib - 1B
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EEG Analytics to Determine Effectiveness of a tDCS Protocol
Status: COMPLETED
Conditions: Healthy|EEG|Transcranial Magnetic Stimulation
Interventions: DIAGNOSTIC_TEST: Transcranial Direct Current Stimulation|DIAGNOSTIC_TEST: Transcranial Magnetic Stimulation|DIAGNOSTIC_TEST: Electroencephalography (EEG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ibuprofen Versus Indomethacin Following Emergent Cerclage Placement
Status: ENROLLING_BY_INVITATION
Conditions: Preterm Labor
Interventions: DRUG: Indomethacin 150mg|DRUG: Ibuprofen 2400mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Variation in Urine Electrolytes, pH and Specific Gravity Throughout the Day
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Normal fluid intake without true lemon|DIETARY_SUPPLEMENT: Double fluid intake plus 3 bottles of water with True Lemon
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Definitive Selection of Neuroimaging Biomarkers in Anxiety Disorder and Obsessive-compulsive Disorder: A Longitudinal Functional Magnetic Resonance Imaging （fMRI） Study With Paroxetine Treatment
Status: COMPLETED
Conditions: Anxiety Disorder|Obsessive-Compulsive Disorder
Interventions: DRUG: Paroxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Electrical Spinal Cord Stimulation for Lower Limbs
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: DEVICE: Transcutaneous Electrical Spinal Cord Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Olmesartan Medoxomil in Atherosclerosis
Status: COMPLETED
Conditions: Essential Hypertension|Atherosclerotic Cardiovascular Disease
Interventions: DRUG: Olmesartan medoxomil|DRUG: Atenolol|DRUG: Hydrochlorothiazide|DRUG: olmesartan medoxomil|DRUG: atenolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Reactance Parameters Measured by the Forced Oscillation Technique for the Bronchodilator Response in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Duovent HFA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: rTMS for Depressive, Positive and Negative Symptoms, and Physiological Indices of Schizophrenia Patients
Status: RECRUITING
Conditions: Schizophrenia and Related Disorders
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Ultrasound to Predict the Results of Draining Pleural Effusions
Status: TERMINATED
Conditions: Pleural Effusion
Interventions: OTHER: Pleural Manometry|OTHER: Thoracic ultrasonography|PROCEDURE: Pleural aspiration catheter OR chest drain (standard care)|PROCEDURE: Talc slurry pleurodesis via chest drain (standard care)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Plant Sterols on the Blood Lipid Profile of Subjects With and at High Risk of Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Vascular Diseases|Hypercholesterolemia|Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Plant sterols|DIETARY_SUPPLEMENT: Placebo product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 3 Study of Efepoetin Alfa for Treatment of Anemia in Patients With Chronic Kidney Disease on Dialysis
Status: RECRUITING
Conditions: Anemia of Chronic Kidney Disease
Interventions: DRUG: Efepoetin Alfa|DRUG: Darbepoetin Alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SAP Versus ESP Block in Multimodal Pain Management in Mini-invasive Thoracic Surgery: an Observational Prospective Multicentric Study
Status: UNKNOWN
Conditions: SAP Block Versus ESP Block|Pain, Postoperative|Evaluation of Locoregional Techniques|Multimodal Pain Management
Interventions: PROCEDURE: SAP block|PROCEDURE: ESP block
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Topical Lidocaine on Warm and Cold Sensation in Healthy Individuals
Status: UNKNOWN
Conditions: Neuropathy;Peripheral|Thermal Hypesthesia
Interventions: DIAGNOSTIC_TEST: Xylocaine spray 100mg/ml|DIAGNOSTIC_TEST: Ethanol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Esketamine Anesthesia in Thoracic Surgery
Status: NOT_YET_RECRUITING
Conditions: General Anesthesia|Thoracic Surgery
Interventions: DRUG: Esketamine|DRUG: Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: National Registry for Ichthyosis and Related Disorders
Status: COMPLETED
Conditions: Darier Disease|Hailey-Hailey Disease|Hyperkeratosis, Epidermolytic|Ichthyosis|Ichthyosis, Lamellar|Ichthyosis, X-Linked|Keratoderma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: GABA Antagonist to Improve Reversal of Anesthesia With High-density EEG Surveillance
Status: UNKNOWN
Conditions: Moderate Sedation|Colonoscopy
Interventions: DRUG: flumazenil|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessment of Clinical Onset of IV Heparin in Interventional Cardiology and Cardiac Surgery
Status: UNKNOWN
Conditions: Transcatheter Aortic Valve Replacement|Cardiac Valve Annuloplasty
Interventions: DIAGNOSTIC_TEST: iStat Handheld Blood Analyzer|DIAGNOSTIC_TEST: Hemochron
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial of Comparing the Pathology Status of Lymphoseek®-Identified Sentinel Lymph Nodes Relative to the Pathological Pathology Status of Nonsentinel Lymph Nodes in Nodal Staging of Subjects With Known Cancer of the Cervix Who Are Undergoing Lymph Node Dissection
Status: TERMINATED
Conditions: Uterine Cervical Neoplasms
Interventions: DRUG: Tc99m tilmanocept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Alternate Day Dosing of Pomalidomide in Patients With Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Refractory Multiple Myeloma
Interventions: DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online, Gut-directed Hypnotherapy for Patients With Irritable Bowel Syndrome (IBS)
Status: RECRUITING
Conditions: IBS - Irritable Bowel Syndrome
Interventions: BEHAVIORAL: Gut-directed hypnotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of DNA Vaccine With Electroporation for the Prevention of Disease Caused by H1 and H5 Influenza Virus
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: INO-3605|BIOLOGICAL: INO-3609|BIOLOGICAL: INO-3401|BIOLOGICAL: INO-3609|BIOLOGICAL: INO-3605 AND INO-3609|BIOLOGICAL: INO-3510|BIOLOGICAL: INO-3609|BIOLOGICAL: INO-3609|BIOLOGICAL: Seasonal Influenza vaccine|BIOLOGICAL: INO-3609
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Efficacy and Safety of Secukinumab 2 mL Auto-injector (300 mg) in Subjects With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Placebo 2 mL auto-injector|DRUG: Placebo 1 mL prefilled syringe|DRUG: Secukinumab 2 mL auto-injector|DRUG: Secukinumab 1 mL prefilled syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Genomic Guided Therapy With Dasatinib or Nilutamide in Metastatic Castration-Resistant Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Nilutamide|DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Carbohydrate Consumption on Fatigue and Muscle Damage in Jiu-Jitsu Athletes
Status: COMPLETED
Conditions: Fatigue|Exercise-induced Muscle Damage
Interventions: DIETARY_SUPPLEMENT: Carbohydrate (maltodextrin)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 1 Study To Evaluate Escalating Doses Of A Vaccine-Based Immunotherapy Regimen For Prostate Cancer (PrCa VBIR)
Status: TERMINATED
Conditions: Prostatic Neoplasms
Interventions: BIOLOGICAL: PF-06755992|BIOLOGICAL: PF-06755990|DEVICE: TDS-IM Electroporation Device|BIOLOGICAL: Tremelimumab|BIOLOGICAL: PF-06801591|BIOLOGICAL: PF-06753512
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Nasal Lubricant Compared to Placebo on Snoring
Status: UNKNOWN
Conditions: Snoring|Sleep Disorder
Interventions: DEVICE: Roncoliv|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Renal Hemodynamics and Tubular Function in Patients With Obstructive Sleep Apnea and Healthy Controls
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Healthy
Interventions: DRUG: L-NMMA (N-mono.methyl-L-arginine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety, Tolerability and Preliminary Efficacy of FP-1201 in ALI and ARDS. Phase I/II
Status: COMPLETED
Conditions: Acute Lung Injury|Acute Respiratory Distress Syndrome
Interventions: DRUG: Interferon Beta
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Paclitaxel (Albumin-binding) for Castration-resistant Prostate Cancer
Status: UNKNOWN
Conditions: Castration-resistant Prostate Cancer
Interventions: DRUG: nab-paclitaxel|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Percutaneous Tibial Nerve Stimulation (PTNS) Improve Outcomes in Patients Presenting With Fecal Incontinence
Status: TERMINATED
Conditions: Fecal Incontinence
Interventions: DEVICE: Posterior tibial nerve stimulation (PTNS)|DEVICE: Posterior tibial nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Edwards Lifesciences Self-Expanding Stent Peripheral Vascular Disease Study
Status: COMPLETED
Conditions: Intermittent Claudication|Atherosclerotic Disease|Arterial Occlusive Disease
Interventions: OTHER: Percutaneous Transluminal Angioplasty|DEVICE: LifeStent NT™ Self-Expanding Peripheral Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaginal Dinoprostone Administration Prior to a T380A Intrauterine Device Insertion in Nulliparous Women.
Status: COMPLETED
Conditions: Intrauterine Device
Interventions: DRUG: Dinoprostone 3 mg|DRUG: placebo vaginal tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study
Status: RECRUITING
Conditions: Obstructive Sleep Apnea|Cognitive Decline
Interventions: DEVICE: Positive airway pressure|DEVICE: Oral appliance therapy|DEVICE: Positional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetics of Epilepsy and Related Disorders
Status: RECRUITING
Conditions: Epilepsy|Epileptic Encephalopathy|Ohtahara Syndrome|Infantile Spasms|Dravet Syndrome|Early Myoclonic Epileptic Encephalopathy|PCDH19-related Epilepsy and Related Conditions|KCNQ2-Related Epileptic Encephalopathy|Epilepsy of Infancy With Migrating Focal Seizures (Disorder)
Interventions: GENETIC: Exome and/or whole genome sequencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Evaluating the Efficacy and Safety of Guselkumab Administered Subcutaneously in Participants With Active Psoriatic Arthritis
Status: COMPLETED
Conditions: Arthritis, Psoriatic
Interventions: DRUG: Guselkumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Mometasone Furoate/Formoterol Combination Versus Mometasone Furoate Alone in Persistent Asthmatics (Study P04431AM2)(COMPLETED)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Mometasone furoate/formoterol (MF/F) combination|DRUG: Mometasone furoate/formoterol (MF/F) combination|DRUG: Mometasone furoate MDI (MF MDI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Secondary Event Prevention Using Population Risk Management After PCI and for Anti-Rheumatic Medications
Status: ACTIVE_NOT_RECRUITING
Conditions: Myocardial Ischemia|Rheumatic Diseases
Interventions: OTHER: Caplan IVR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Salivary Inflammatory Biomarkers: Predictors & Comparative Effects of Sonicare/Elite-Flexcare in Stages of Perio Disease
Status: COMPLETED
Conditions: Inflammation|Periodontitis
Interventions: OTHER: Sonicare/Elite-Flexcare Toothbrush|OTHER: Manual Toothbrush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Revisiting the Mechanism of the Anti-inflammatory Effect of Colchicine
Status: UNKNOWN
Conditions: Colchicine Mechanism of Action
Interventions: DRUG: Colchicine Tablets|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial of Episil® Oral Liquid in Cancer Patients Suffering From Chemotherapy- and/or Radiation-induced Oral Mucositis
Status: COMPLETED
Conditions: Chemotherapy- and/or Radiation-induced Oral Mucositis
Interventions: DEVICE: episil®|DEVICE: Kang Su
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PET Scans in Patients With Locally Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: positron emission tomography|RADIATION: fludeoxyglucose F 18|RADIATION: iodine I 124 iododeoxyuridine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: High Dose Vit D Musculoskeletal Symptoms & Bone Density in Anastrozole-Treated Breast Cancer With Marginal Vit D Status
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: Calcium carbonate|DRUG: Vitamin D|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Characterizing Skin Microbiome Change in Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis|Atopic Dermatitis Eczema
Interventions: DRUG: Crisaborole 2% Top Oint|GENETIC: Skin Microbiome Swabs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The McGill RAAS-COVID-19 Trial
Status: COMPLETED
Conditions: COVID-19|Cardiovascular Diseases
Interventions: OTHER: Temporarily holding the RAAS inhibitor [intervention]|OTHER: RAAS inhibitor [continued standard of care]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT