pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumors Harboring NTRK Fusion
Interventions: DRUG: BAY2757556 (Larotrectinib, Vitrakvi)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Meibomian Gland Dysfunction Management With ZEST Protocol
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction|Dry Eye Syndromes|Ocular Surface Disease
Interventions: OTHER: Zocular Eyelid System Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity & Safety Study of Fluviral® (2009 - 2010 Season) in Adults Aged 18 to 60 Years and Over 60 Years
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: Fluviral®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Peginterferon Alfa-2a With or Without Ribavirin in Participants With Chronic Hepatitis D (CHD)
Status: COMPLETED
Conditions: Hepatitis D, Chronic
Interventions: DRUG: Peginterferon alfa-2a|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antineoplaston Therapy in Treating Patients With Stage IV Pancreatic Cancer
Status: TERMINATED
Conditions: Stage IV Pancreatic Cancer
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemoradiotherapy in Stage III Non-small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Stage III Non-small Cell Lung Cancer
Interventions: DRUG: Chemotherapy|DRUG: ERBITUX|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Clinical Outcomes in Fresh Cycle With Single Blastocyst Stage and Double Cleavage-stage Embryos: a Single-center, Non-blind, Randomized Controlled Study
Status: NOT_YET_RECRUITING
Conditions: Infertility, Female
Interventions: PROCEDURE: double cleavage-stage or single blastocyst stage embryos transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Randomized, Parallel Group, Double-Blind, Placebo Controlled, Flexible Dose Escalation Study To Evaluate Sexual And Relationship Satisfaction In The Female Partner Of Men With Erectile Dysfunction Treated With Sildenafil Citrate
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: sildenafil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Natalizumab + Prednisone for Initial Therapy of Acute GI GVHD
Status: COMPLETED
Conditions: Graft Versus Host Disease
Interventions: DRUG: Natalizumab|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hybrid Revascularization Versus Coronary Artery Bypass Grafting
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Hybrid coronary revascularization|PROCEDURE: Conventional revascularization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2, Multicenter, Open-label Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Pefcalcitol Ointment, 0.005%, Applied Topically Twice Daily (BID) for 8 Weeks in Adolescent Subjects 12 to < 17 Years of Age With Plaque Psoriasis
Status: WITHDRAWN
Conditions: Psoriasis
Interventions: DRUG: pefcalcitol ointment, 0.005%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carotid Artery Stenting With Emboli Protection Surveillance-Post-Marketing Study (CASES-PMS)
Status: COMPLETED
Conditions: Carotid Artery Disease
Interventions: DEVICE: -PRECISE Nitinol Stent System (5F, 5.5F and 6F)|DEVICE: ANGIOGUARD™ XP Emboli Capture Guidewire (ECGW)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strong Hearts: Rural CVD Prevention
Status: COMPLETED
Conditions: Heart Disease|Cardiovascular Disease|Sedentary Lifestyle|Overweight|Obesity
Interventions: BEHAVIORAL: Strong Hearts, Healthy Communities|BEHAVIORAL: Strong Hearts, Healthy Women
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Initial Safety Study of Gedatolisib Plus PTK7-ADC for Metastatic Triple-negative Breast Cancer
Status: COMPLETED
Conditions: Triple Negative Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: Gedatolisib|DRUG: PTK7-ADC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydrochlorothiazide for Kidney Stone Recurrence Prevention
Status: COMPLETED
Conditions: Nephrolithiasis
Interventions: DRUG: Placebo oral capsule|DRUG: 12.5 mg hydrochlorothiazide|DRUG: 25.0 mg hydrochlorothiazide|DRUG: 50.0 mg hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: The Effect of CIC Education on QOL and Compliance With Mobile Application in Individuals With Spinal Cord Injury.
Status: ENROLLING_BY_INVITATION
Conditions: Neurogenic Bladder|Spinal Cord Injury|Intermittent Catheterization|Mobile Application
Interventions: DEVICE: mobile application on telephone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Air Pollution and Allergens - Attenuation of Health Effects Particle Reduction
Status: COMPLETED
Conditions: Allergies
Interventions: OTHER: Allergen|OTHER: Saline|OTHER: Particle depleted diesel exhaust
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 2 Study MPC-6827 for Recurrent Glioblastoma Multiforme
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Azixa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adapted Motivational Interviewing and Cognitive Behavioural Therapy for Food Addiction
Status: COMPLETED
Conditions: Food Addiction|Binge Eating
Interventions: BEHAVIORAL: Adapted Motivational Interviewing (AMI) and Cognitive Behavioural Therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaginal Progesterone in Twin With Short Cervix
Status: COMPLETED
Conditions: Preterm Birth|Twin Dichorionic Diamniotic Placenta
Interventions: DRUG: Progesterone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Interest of APA in Fatty Liver Disease Evaluation of Efficacy and Adherence to an Adapted Physical Activity (APA) Program in Patients With Metabolic Fatty Liver Disease
Status: RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease (NAFLD
Interventions: OTHER: adapted physical activity + Dietetic advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety and Tolerability of Alirocumab (SAR236553/REGN727) Versus Placebo on Top of Lipid-Modifying Therapy in High Cardiovascular Risk Patients With Hypercholesterolemia (ODYSSEY Long Term)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Placebo (for alirocumab)|DRUG: Alirocumab|DRUG: Lipid-Modifying Therapy (LMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of High-Dose Vitamin D on Bone Density in Osteogenesis Imperfecta
Status: COMPLETED
Conditions: Osteogenesis Imperfecta
Interventions: DIETARY_SUPPLEMENT: standard-dose vitamin D (400IU per day)|DIETARY_SUPPLEMENT: high-dose vitamin D (2000 IU per day)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase I, Open-label, Dose-escalation, Safety and PK Study of AZD6918
Status: TERMINATED
Conditions: Cancer,|Solid Tumors|Advanced Solid Malignancies
Interventions: DRUG: AZD6918|DRUG: gemcitabine|DRUG: pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Tolerability of a Combination of Antidepressant and Peptic Ulcer Drug in Overweight Healthy Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Sertraline plus Telenzepine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Characteristics of Different Personal Lancets on Blood Volume and Perceived Pain in Patients With Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DEVICE: Droplet lancing device (HTL-Strefa S.A.)|DEVICE: Microlet 2 lancing device (Bayer)|DEVICE: OneTouch Delicia lancing device (LifeScan)|DEVICE: ReliOn lancing device (ReliOn)|DEVICE: Accu-Chek Softclix lancing device (Roche)|DEVICE: BGStar lancing device (Sanofi Aventis)|DEVICE: Ultra-Fine 33G lancets (BD)|DEVICE: Droplet 33G lancets (HTL-Strefa S.A.)|DEVICE: OneTouch Delicia Extra Fine 33G lancets (LifeScan)|DEVICE: HaemoFine 33G lancets (HTL-Strefa S.A.)|DEVICE: Softclix 28 G lancets (Roche)|DEVICE: ReliOn Ultra-Thin Plus 33G lancets (ReliOn)|DEVICE: GlucoJect Dual S lancing device (Menarini)|DEVICE: Microlet 28G lancets (Bayer)|DEVICE: BGStar Ultra-Thin 33G lancets (Sanofi Aventis)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Randomized, Double-blind, Crossover, Pharmacokinetic (PK) and Glucodynamic (GD) Study of Continuous Subcutaneous Insulin Infusion (CSII) in Participants With Type 1 Diabetes Mellitus (T1DM)
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Insulin aspart|DRUG: Recombinant human hyaluronidase PH20 (rHuPH20)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: L-citrulline and Metformin in Becker's Muscular Dystrophy
Status: COMPLETED
Conditions: Becker's Muscular Dystrophy (BMD)
Interventions: DRUG: Metformin and Metformin & L-Citrulline|DRUG: L-Citrulline and Metformin & L-Citrulline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Botulinum Toxin on Hamstring Contracture and the Occurrence of Cyclops Syndrome After Anterior Cruciate Ligament Reconstruction
Status: NOT_YET_RECRUITING
Conditions: Hamstring Contractures
Interventions: DRUG: Botulinum toxin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Study of Gepotidacin
Status: COMPLETED
Conditions: Infections, Bacterial
Interventions: DRUG: Gepotidacin|DRUG: Cimetidine|DRUG: Rifampicin|DRUG: Midazolam|DRUG: Digoxin|OTHER: Placebo matching to gepotidacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Topotecan in Children With Recurrent Wilms Tumor
Status: COMPLETED
Conditions: Wilms Tumor
Interventions: DRUG: Topotecan, Filgrastim (G-CSF), Pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Narrative Enhancement and Cognitive Therapy (NECT) on Self-stigma in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: OTHER: Narrative Enhancement and Cognitive Therapy (NECT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Neurotensin Infusions in Healthy Individuals -
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Neurotensin|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Durability of Combination of Insulin and GLP-1 Receptor Agonist or SGLT-2 Inhibitors Versus Basal Bolus Insulin Regimen in Type 2 Diabetes (BEYOND)
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: IDegLira|DRUG: IGlarLixi|DRUG: Insulin/Canaglifozin|DRUG: Insulin/Dapaglifozin|DRUG: Insulin/Empaglifozin|DRUG: Basal Bolus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Understanding the Post-Surgical Non-Small Cell Lung Cancer Patient's Symptom Experience
Status: COMPLETED
Conditions: Fatigue|Self Efficacy|Quality of Life|Physical Activity|Lung Cancer|Non-Small Cell Lung Cancer
Interventions: BEHAVIORAL: Light Physical Activity 1|BEHAVIORAL: Light Physical Activity 2|BEHAVIORAL: Support Education Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: AIN457 Regimen Finding Study in Patients With Moderate to Severe Psoriasis
Status: COMPLETED
Conditions: Chronic Plaque-type Psoriasis
Interventions: DRUG: AIN457|DRUG: AIN457A|DRUG: AIN457A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oxytocin Aging Study
Status: TERMINATED
Conditions: Inflammation
Interventions: DRUG: Intranasal Oxytocin spray|OTHER: Intranasal Placebo spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Physical Treatments of Human Milk on the Kinetics of Gastric Lipolysis in Preterm Newborns
Status: COMPLETED
Conditions: Premature Birth
Interventions: OTHER: Raw human milk|OTHER: Pasteurized human milk|OTHER: Pasteurized-homogenized human milk|OTHER: Gastric samples
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bread Supplemented With Chilean Beans to Decrease Postprandial Glycoxidative Responses: A Pilot Intervention
Status: ACTIVE_NOT_RECRUITING
Conditions: Aging
Interventions: OTHER: Nutritional acute postprandial intervention: Control bread|OTHER: Nutritional acute postprandial intervention: bread suppelmented with Chilean beans|OTHER: Nutritional acute postprandial intervention: Control glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A PhaseⅠStudy of ONO-7475 in Combination With ONO-4538 and Gemcitabine Plus Nab-paclitaxel (GnP), the Standard of Care, and ONO-7475 in Combination With GnP in Patients With Pancreatic Cancer
Status: RECRUITING
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: ONO-7475|DRUG: ONO-4538|DRUG: Nab-paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Alternative Formats vs Standard of SoF Tables. Non-inferiority Controlled Trial
Status: COMPLETED
Conditions: GRADE Approach|Summary of Findings Table|Cochrane Collaboration
Interventions: OTHER: Alternative summary of findings table format|OTHER: Current summary of findings table format
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pilot Study on Intra-abdominal Photodynamic Diagnosis in Peritoneal Carcinosis
Status: UNKNOWN
Conditions: Peritoneal Carcinomatosis
Interventions: DRUG: St. John's Wort|DEVICE: Photodynamic diagnostic and therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Quality of Recovery From General Anesthesia With Desflurane for Fundus Surgery
Status: NOT_YET_RECRUITING
Conditions: Desflurane Anesthesia|Postoperative Recovery
Interventions: DRUG: Desflurane Inhalant Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Clinical Effectiveness and Bacteriological Eradication of 4 Short-course Antibiotics for Uncomplicated UTIs in Women.
Status: RECRUITING
Conditions: Urinary Tract Infections
Interventions: DRUG: Fosfomycin Trometamol Salt|DRUG: Nitrofurantoin|DRUG: Pivmecillinam|DRUG: Fosfomycin Trometamol Salt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study in Healthy Participants, 200mg Tablets ZSP1273 Versus 200mg Granules ZSP1273
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: ZSP1273 tablet|DRUG: zsp1273 granules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of EPA-enriched Supplement in Malnourished Head and Neck Cancer Patients Undergone Surgery
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DIETARY_SUPPLEMENT: EPA-enriched supplement|DIETARY_SUPPLEMENT: standard formula supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimization of Interval Exercise Based-intensity on Ventilatory Anaerobic Threshold in Coronary Artery Disease
Status: UNKNOWN
Conditions: Coronary Artery Disease|Cardiovascular Risk Factors
Interventions: OTHER: Interval training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Early Tracheostomy to Reduce Incidence of Ventilator Acquired Pneumonia (VAP)
Status: COMPLETED
Conditions: Respiratory Insufficiency
Interventions: PROCEDURE: Tracheostomy on day 3-5 in early group and 10-12 in late group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effects of Tradipitant vs. Placebo in Atopic Dermatitis (EPIONE)
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Tradipitant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxytocin Induction in Full Term Pregnant Women With Cesarean Section of Prelabor Rupture of Membranes
Status: RECRUITING
Conditions: Failed Trial of Labor, Unspecified, With Delivery|Failed VBAC (Vaginal Birth After Caesarean)|Prelabor Rupture of Membranes|Failed Induction (of Labor) by Oxytocin
Interventions: DRUG: Oxytocin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of an Avatar-Based Education Program on Shunt Complications and Parents' Knowledge and Care Skills
Status: COMPLETED
Conditions: Developing the ABEP-H|Determining the Effect of ABEP-H
Interventions: OTHER: Avatar-Based Education Program in Hydrocephalus (ABEP-H)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Analgesic Efficacy of Trans-muscular Quadratus Lumborum Block After Unilateral Inguinal Hernia Repair
Status: COMPLETED
Conditions: Postoperative Pain|Ultrasound Guided Nerve Block
Interventions: OTHER: ultrasound guided quadratus lumborum block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nanotechnology Structured Water Magnalife for the Prevention of Recurrent Urinary Tract Infections.
Status: COMPLETED
Conditions: Recurrent Urinary Tract Infection
Interventions: DIETARY_SUPPLEMENT: Nanotechnology Structured water Magnalife|DRUG: Trimethoprim|DIETARY_SUPPLEMENT: Ordinary bottled drinking water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Adjunctive Selective Estrogen Receptor Modulators on Negative and Cognitive Symptoms of Schizophrenia in Women
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Raloxifene Hydrochloride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficiency of Triple Antibiotic Paste, Ciprofloxacin/Propolis, Ciprofloxacin/Metronidazole, Propolis/Metronidazole Combinations on Revascularization Process of Immature Necrotic Maxillary Incisors of Patients 8-18 Years Old.
Status: COMPLETED
Conditions: Dental Pulp Necrosis|Periapical Abscess|Root Canal Infection
Interventions: COMBINATION_PRODUCT: Canal Disinfection Triple Antibiotic Paste (TAP)|COMBINATION_PRODUCT: Ciprofloxacin + Propolis Paste|COMBINATION_PRODUCT: Ciprofloxacin + Metronidazole Paste|COMBINATION_PRODUCT: Propolis + Metronidazole paste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Multi-disciplinary Prevention Program
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: SYSTAM - SP-ED|DEVICE: Ultrasling ER 15°Donjoy - 4P-ED
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Monitoring of Arrhythmias and HRV in Patients With Heart Failure Treated With the CRT Pacemaker Renewal TR2
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: DEVICE: Renewal TR2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Using Custom Photobiomodulation Therapy for the Treatment of Osteoarthritis of the Fingers and Rhizarthrosis
Status: COMPLETED
Conditions: Osteoarthritis|Osteoarthritis Finger|Osteoarthritis Hand|Osteoarthritis Both Hands
Interventions: DEVICE: Photobiomodulation therapy (PBT)|DEVICE: Sham Photobiomodulation therapy (Sham PBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacodynamics (PD), Pharmacokinetics (PK) Study of SHP141 in 1A, 1B, or 2A Cutaneous T-Cell Lymphoma (CTCL)
Status: COMPLETED
Conditions: Lymphoma, T-Cell, Cutaneous
Interventions: DRUG: placebo for SHAPE (SHP-141)|DRUG: SHAPE (SHP-141) 0.1% BID|DRUG: SHAPE (SHP-141) 0.5% BID|DRUG: SHAPE (SHP-141) 1.0% BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of MSDC-0602K to Assess Glycemic Control and Cardiovascular Outcomes in Patients With Pre-T2D or T2D and NAFLD/NASH
Status: UNKNOWN
Conditions: Type2 Diabetes|NASH - Nonalcoholic Steatohepatitis|Nonalcoholic Steatohepatitis|Non-Alcoholic Fatty Liver Disease
Interventions: DRUG: MSDC-0602K|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuroimaging the Expectancy Versus Pharmacotherapy Effect of Adderall on Cognitive Performance
Status: COMPLETED
Conditions: Expectancy Versus Pharmacotherapy Effect of Adderall
Interventions: DRUG: Adderall|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: TPF Induction Chemotherapy for Locally Advanced and Resectable Oral Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Stage III Oral Cavity Squamous Cell Carcinoma|Stage IVA Oral Cavity Squamous Cell Carcinoma
Interventions: DRUG: TPF induction chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bivalirudin vs Heparin in NSTEMI and STEMI in Patients on Modern Antiplatelet Therapy in SWEDEHEART
Status: COMPLETED
Conditions: ST-segment Elevation Myocardial Infarction|Non ST-segment Elevation Myocardial Infarction
Interventions: DRUG: bivalirudin|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Median Effective Dose of Ciprofol-Assisted Sedation for Elderly Patients Undergoing Knee Arthroplasty
Status: COMPLETED
Conditions: Sedation|ED50|Knee Arthroplasty
Interventions: DRUG: Ciprofol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Self-directed Mobile Intervention to Promote Weight Control Among Employees of a Lebanese University
Status: COMPLETED
Conditions: Body Weight Changes|Overweight and Obesity|Sedentary Lifestyle|Health Behavior
Interventions: COMBINATION_PRODUCT: Lark (JITAI)|COMBINATION_PRODUCT: MyFitnessPal (no JITAI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Magnetic Fields to Treat Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: magnetic therapy protocol A|DEVICE: magnetic therapy Protocol B|DEVICE: placebo therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Renal Denervation in Patients With Uncontrolled Hypertension in Chinese
Status: UNKNOWN
Conditions: Hypertension
Interventions: DEVICE: THERMOCOOL® Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lipoic Acid Supplement for Cystine Stone
Status: ACTIVE_NOT_RECRUITING
Conditions: Cystinuria
Interventions: DIETARY_SUPPLEMENT: Alpha lipoic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Desarda Repair Compared to Lichtenstein Repair for the Treatment of Inguinal Hernias
Status: COMPLETED
Conditions: Postoperative Pain|Recurrence|Wound Complication
Interventions: PROCEDURE: Desarda repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Diet With Hyperproteic Supplement Versus a Supplement With Imunonutrients, in Colorectal Cancer Surgery
Status: UNKNOWN
Conditions: Nutrition Related Neoplasm/Cancer|Colorectal Cancer|Surgery--Complications|Site Infection|Nutrition Support
Interventions: DIETARY_SUPPLEMENT: Nutrition supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Antiviral Activity of Monoclonal Antibody VRC01 in Infants With HIV Receiving Combination Antiretroviral Therapy
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: VRC01|DRUG: Combination Antiretroviral Therapy (cART)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effect of TAP Block After Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Laparoscopic Cholecystectomy|Postoperative Analgesia
Interventions: PROCEDURE: Bilateral subcostal TAP block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis
Status: TERMINATED
Conditions: Bacterial Meningitis
Interventions: PROCEDURE: Mild induced hypothermia (32-34°C)|PROCEDURE: local recommendations and guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Broccoli Sprout Extracts in Healthy Volunteers: A Pilot Study of Nrf2 Pathway Modulation in Oral Mucosa
Status: COMPLETED
Conditions: Healthy Subject
Interventions: DRUG: Broccoli Sprout Extract (BSE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Cerebrolysin on Level of Consciousness and Brain Metabolism in Disorder of Consciousness After Stroke: Single Center Randomized Controlled Study
Status: UNKNOWN
Conditions: Stroke
Interventions: DRUG: Cerebrolysin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BV-CHEP Chemotherapy for Adult T-cell Leukemia or Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma|Adult T-Cell Leukemia/Lymphoma|Lymphatic Diseases
Interventions: DRUG: Brentuximab Vedotin|DRUG: CHEP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Educational Intervention for Reducing Work Disability in Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer|Cancer Survivor
Interventions: OTHER: internet-based intervention|PROCEDURE: management of therapy complications|OTHER: educational intervention|OTHER: questionnaire administration|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase I Study of Weekly Intravenous PS-341 (Bortezomib) Plus Mitoxantrone
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Mitoxantrone (Novantrone)|DRUG: Bortezomib (PS-341)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Roxadustat to Treat Anemia in Patients With Chronic Kidney Disease, on Dialysis.
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Roxadustat|DRUG: Epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Trial to Assess the Tolerability of AVANZ Phleum Pratense Immunotherapy
Status: COMPLETED
Conditions: Allergic Rhinoconjunctivitis
Interventions: DRUG: AVANZ Phleum pratense
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Belzutifan|DRUG: Lenvatinib|DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: R-Dose-adjusted (DA) - EPOCH-21 Versus R-modified Non-Hodgkin Lymphoma (NHL)-Berlin-Frankfurt-Munster (BFM)-90 Program (mNHL-BFM-90) and Autologous Stem Cells Transplantation (Auto-SCT) in DLBCL With Poor Prognosis
Status: UNKNOWN
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: R-DA-EPOCH-21|DRUG: R-DA-EPOCH-21 + auto-SCT|DRUG: R-mNHL-BFM-90|DRUG: R-mNHL-BFM-90 + auto-SCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MusculRA: The Effects of Rheumatoid Arthritis on Skeletal Muscle Biomechanics
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Healthy Controls
Interventions: OTHER: Blood Draw|OTHER: Disease Activity (DAS-28) Assessment|OTHER: Skeletal Muscle Mitochondrial Respiratory Capacity|OTHER: Muscle Biopsy|OTHER: Body Composition|OTHER: Cardiopulmonary Exercise Test (CPET)|OTHER: Strength Testing|OTHER: Questionnaires|OTHER: Skeletal Muscle Biomechanical Property Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Improved Prevention of Stroke in Primary Care in Stockholm, Sweden (Förbättrad Prevention av Stroke)
Status: COMPLETED
Conditions: Ischemic Stroke|Hemorrhagic Stroke|TIA|Atrial Fibrillation
Interventions: BEHAVIORAL: structured collegial feed back
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Standardized Fecal Microbiota Transplantation for Crohn&Apos;s Diseases
Status: RECRUITING
Conditions: Crohn's Diseases|Inflammatory Bowel Disease
Interventions: PROCEDURE: FMT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyclophosphamide, Lenalidomide and Dexamethasone (CRD) Versus Melphalan (200 mg/m2) Followed By Autologous Stem Cell Transplant (ASCT) In Newly Diagnosed Multiple Myeloma Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Cyclophosphamide|DRUG: Lenalidomide|DRUG: Dexamethasone|DRUG: Melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Certolizumab Pegol for Treatment of Adult Greek Patients With Moderate to Severe Crohn's Disease Who Failed Infliximab
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: Certolizumab pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Valproate Versus Topiramate in Migraine
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: DRUG: Valproic acid|DRUG: Topiramate 50 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IV Tranexamic Acid Prior to Hysterectomy
Status: COMPLETED
Conditions: Hysterectomy|Blood Loss, Surgical
Interventions: DRUG: Tranexamic Acid|DRUG: Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Planetary Health and Loneliness
Status: RECRUITING
Conditions: Loneliness|Anxiety|Health-Related Behavior|Healthy Lifestyle|Healthy Nutrition|Healthy Diet|Health Behavior
Interventions: BEHAVIORAL: Prompting open-ended question promoting sustainability|BEHAVIORAL: Sustainability Passage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of Remternetug (LY3372993) in Participants With Alzheimer's Disease (TRAILRUNNER-ALZ 1)
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer's Disease
Interventions: DRUG: Remternetug (IV)|DRUG: Remternetug (SC)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment II-3 - 6
Status: WITHDRAWN
Conditions: Heroin Dependence|Opioid-Related Disorders
Interventions: DRUG: Test Drug|DRUG: Placebo Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Anesthetic Impregnated Bandage Soft Contact Lens (BSCL) in Pain Management After Photorefractive Keratectomy (PRK)
Status: UNKNOWN
Conditions: Myopia|Hypermetropia|Refractive Errors|Astigmatism
Interventions: DRUG: Proparacaine Ophthalmic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: [KJ-INT-002] BE Study
Status: UNKNOWN
Conditions: Gastritis
Interventions: DRUG: INT-2150|DRUG: Irsogladine maleate 2 mg+Nizatidine 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Open Kinetic Chain Shoulder Exercises on Scapulothoracic Muscle Activity on Stable and Unstable Ground
Status: NOT_YET_RECRUITING
Conditions: Muscle Weakness|Exercise
Interventions: OTHER: Open cinetic chain shoulder exercise on unstabil ground
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of the Synergistic Impact of Needle and Forceps Biopsy With Electromagnetic Navigation Bronchoscopy
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer|Lung Cancer (Diagnosis)
Interventions: DEVICE: Device for performing biopsy via electromagnetic navigation bronchoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of TPN171H on Spermatogenesis
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: TPN171H 10mg|DRUG: TPN171H Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Muscle Growth Following a Resistance Training Program in Men and Women Consuming Protein Supplements
Status: COMPLETED
Conditions: Skeletal Muscle Growth
Interventions: DIETARY_SUPPLEMENT: Whey protein supplement|DIETARY_SUPPLEMENT: Soy protein supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effects of Training Using Volume and Flow-oriented Incentive Spirometry in Healthy Subjects - Case-control Study
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Voldyne group (VG)|OTHER: Cliniflo group (CG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Tegaserod on Patterns of Flow in the Small Bowel of Patients With Irritable Bowel Syndrome (IBS)
Status: TERMINATED
Conditions: Constipation Predominant|Irritable Bowel Syndrome (IBS-C)
Interventions: DRUG: Tegaserod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Vamikibart (RO7200220) in Diabetic Macular Edema
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetic Macular Edema
Interventions: DRUG: Vamikibart|DRUG: Ranibizumab|OTHER: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigate the Aerosol Particle Distribution During Aerosol Generating Procedures
Status: COMPLETED
Conditions: Transmission, Patient Professional|High-flow Nasal Cannula
Interventions: DEVICE: High-flow nasal cannula|DEVICE: Surgical mask|PROCEDURE: bronchoscopy examination|PROCEDURE: intubation|PROCEDURE: tracheostomy|DEVICE: nebulization|DIAGNOSTIC_TEST: Pulmonary function test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comfort and Wearability of Custom-fitted, Mouth-formed and Pre-fabricated Mouthguards for Patients Undergoing Fixed Appliance Therapy
Status: COMPLETED
Conditions: Mouth Protectors
Interventions: DEVICE: Mouthguard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Curcuma Longa L in Rheumatoid Arthritis
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Meriva|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Collagenase Clostridium Histolyticum After Prior Intralesional PRP for Peyronie's Disease
Status: RECRUITING
Conditions: Peyronie Disease|Sexual Dysfunctions, Psychological|Genital Diseases, Male
Interventions: DRUG: Collagenase Clostridium Histolyticum (CCH)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testosterone Replacement in Male Cancer Survivors With Fatigue and Low Testosterone
Status: RECRUITING
Conditions: Hypogonadism, Male|Fatigue Syndrome, Chronic
Interventions: DRUG: Testosterone Undecanoate 750 MG/3 ML Intramuscular Solution [AVEED]|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metronomic Low-Dose Cyclophosphamide and Methotrexate With or Without Bevacizumab in Treating Women With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: bevacizumab|DRUG: cyclophosphamide|DRUG: methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritional Intervention and Rehabilitation Treatment in Patients With Post-COVID Condition
Status: COMPLETED
Conditions: Post-COVID Condition
Interventions: DIETARY_SUPPLEMENT: Active|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Stimulation of the Efferent Loop and Rehabilitation of the Pelvic Floor in the Quality of Life of Patients Who Underwent Anterior Resection of the Rectum (ENESP): Randomized Clinical Trial
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: PROCEDURE: Stimulation of efferent loop|PROCEDURE: Rehabilitation pelvic floor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Exploratory Study to Assess the Pharmacokinetics of AZD5985
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD5985|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Effectiveness of an Off Label Mefloquine Use for the Treatment of Patients With COVID19
Status: COMPLETED
Conditions: Pneumonia, Viral|Respiratory Failure
Interventions: DRUG: Mefloquine|DRUG: Hydroxychloroquine|COMBINATION_PRODUCT: Mefloquine + azithromycin + / - tocilizumab|COMBINATION_PRODUCT: Hydroxychloroquine + azithromycin + / - tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Possible Safety and Efficacy of Fenofibrate in the Prophylaxis of Doxorubicin Induced Cardiotoxicity in Breast Cancer Patients
Status: RECRUITING
Conditions: Breast Cancer Stage 2 and 3
Interventions: DRUG: Fenofibrate|OTHER: Placebo|DRUG: Doxorubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Learn How Safe Elinzanetant is, How it Affects the Body, and How it Moves Into, Through and Out of the Body After Single and Multiple Doses in Japanese Healthy Female Adults
Status: COMPLETED
Conditions: Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men
Interventions: DRUG: Elinzanetant (BAY3427080)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: The Effects of Collateral Meridian Therapy for Knee Osteoarthritis Pain Management
Status: COMPLETED
Conditions: Knee Osteoarthritis|Pain
Interventions: DEVICE: "GEMORE" Multi-Function Electrotherapy Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT