pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Clinical Evaluation of the TITAN™ Total Shoulder System
Status: TERMINATED
Conditions: Arthritis|Arthritis, Degenerative|Rheumatoid Arthritis|Post-traumatic Arthrosis of Other Joints, Shoulder Region|Rotator Cuff Syndrome of Shoulder and Allied Disorders|Fracture|Avascular Necrosis|Joint Instability|Joint Trauma|Dislocation, Shoulder|Pain, Shoulder
Interventions: DEVICE: Integra TITAN™ Total Shoulder Generation 1.0
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy Study of Pembrolizumab in Relapsed, Locally Recurrent Squamous Cell Cancer of the Head and Neck
Status: ACTIVE_NOT_RECRUITING
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Behavioral Treatment of Insomnia in Aging
Status: COMPLETED
Conditions: Aging|Insomnia
Interventions: BEHAVIORAL: Tai Chi Chih (TCC)|BEHAVIORAL: Cognitive Behavior Therapy (CBT)|BEHAVIORAL: Sleep Seminar (SS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 12 Months Clinical Follow-up of Non-Carious Cervical Lesions Restored With New Injectable Composite
Status: COMPLETED
Conditions: Dental Erosion
Interventions: PROCEDURE: Laser Etching|PROCEDURE: Phosphoric acid etching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Ipilimumab and/or Nivolumab in Combination With Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma or Gliosarcoma
Status: COMPLETED
Conditions: Gliosarcoma|Supratentorial Glioblastoma
Interventions: BIOLOGICAL: Ipilimumab|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Nivolumab|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility Study
Status: NOT_YET_RECRUITING
Conditions: Heart Failure|Coronary Artery Disease|Peripheral Artery Disease|Ischemia|Hypertension|Diabetes Mellitus|Cardiomyopathies|Cardiotoxicity
Interventions: OTHER: Clinical Decision Aid|OTHER: Standard Care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Ecological Momentary Assessment Based Smoking Cessation Intervention
Status: ACTIVE_NOT_RECRUITING
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: EMA-based intervention|BEHAVIORAL: EMA-based intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Family Caregiver Palliative Care Intervention in Supporting Caregivers of Patients With Stage II-IV Gastrointestinal, Gynecologic, Urologic and Lung Cancers
Status: COMPLETED
Conditions: Healthy Subject|Localized Transitional Cell Cancer of the Renal Pelvis and Ureter|Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter|Psychosocial Effects of Cancer and Its Treatment|Recurrent Bladder Cancer|Recurrent Cervical Cancer|Recurrent Colon Cancer|Recurrent Gastric Cancer|Recurrent Ovarian Epithelial Cancer|Recurrent Ovarian Germ Cell Tumor|Recurrent Pancreatic Cancer|Recurrent Rectal Cancer|Recurrent Renal Cell Cancer|Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter|Recurrent Urethral Cancer|Recurrent Uterine Sarcoma|Regional Transitional Cell Cancer of the Renal Pelvis and Ureter|Stage II Bladder Cancer|Stage II Renal Cell Cancer|Stage II Urethral Cancer|Stage IIA Cervical Cancer|Stage IIA Colon Cancer|Stage IIA Gastric Cancer|Stage IIA Ovarian Epithelial Cancer|Stage IIA Ovarian Germ Cell Tumor|Stage IIA Pancreatic Cancer|Stage IIA Rectal Cancer|Stage IIA Uterine Sarcoma|Stage IIB Cervical Cancer|Stage IIB Colon Cancer|Stage IIB Gastric Cancer|Stage IIB Ovarian Epithelial Cancer|Stage IIB Ovarian Germ Cell Tumor|Stage IIB Pancreatic Cancer|Stage IIB Rectal Cancer|Stage IIB Uterine Sarcoma|Stage IIC Colon Cancer|Stage IIC Ovarian Epithelial Cancer|Stage IIC Ovarian Germ Cell Tumor|Stage IIC Rectal Cancer|Stage III Bladder Cancer|Stage III Pancreatic Cancer|Stage III Renal Cell Cancer|Stage III Urethral Cancer|Stage IIIA Cervical Cancer|Stage IIIA Colon Cancer|Stage IIIA Gastric Cancer|Stage IIIA Ovarian Epithelial Cancer|Stage IIIA Ovarian Germ Cell Tumor|Stage IIIA Rectal Cancer|Stage IIIA Uterine Sarcoma|Stage IIIB Cervical Cancer|Stage IIIB Colon Cancer|Stage IIIB Gastric Cancer|Stage IIIB Ovarian Epithelial Cancer|Stage IIIB Ovarian Germ Cell Tumor|Stage IIIB Rectal Cancer|Stage IIIB Uterine Sarcoma|Stage IIIC Colon Cancer|Stage IIIC Gastric Cancer|Stage IIIC Ovarian Epithelial Cancer|Stage IIIC Ovarian Germ Cell Tumor|Stage IIIC Rectal Cancer|Stage IIIC Uterine Sarcoma|Stage IV Bladder Cancer|Stage IV Gastric Cancer|Stage IV Ovarian Epithelial Cancer|Stage IV Ovarian Germ Cell Tumor|Stage IV Pancreatic Cancer|Stage IV Renal Cell Cancer|Stage IV Urethral Cancer|Stage IVA Cervical Cancer|Stage IVA Colon Cancer|Stage IVA Rectal Cancer|Stage IVA Uterine Sarcoma|Stage IVB Cervical Cancer|Stage IVB Colon Cancer|Stage IVB Rectal Cancer|Stage IVB Uterine Sarcoma|Ureter Cancer|Stage IIA Lung Carcinoma|Stage IIB Lung Carcinoma|Stage IIIA Lung Carcinoma|Stage IIIB Lung Carcinoma
Interventions: OTHER: educational intervention|BEHAVIORAL: telephone-based intervention|PROCEDURE: quality-of-life assessment|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cuff Pressure Control and Evacuation of Subglottic Secretions To Prevent Pneumonia
Status: COMPLETED
Conditions: Respiratory Failure
Interventions: DEVICE: Continuous cuff pressure regulation|DEVICE: Intermittent cuff pressure regulation|DEVICE: Automatic subglottic secretion drainage|DEVICE: Manual subglottic secretion drainage|DIAGNOSTIC_TEST: Tracheobronchial colonization assessment|DIAGNOSTIC_TEST: Microaspiration assessment|DIAGNOSTIC_TEST: VAP assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Home Blood Pressure (HBP)-Guided Management of Hypertension in Stage 3-4 CKD
Status: UNKNOWN
Conditions: Hypertension|Chronic Kidney Diseases
Interventions: DIAGNOSTIC_TEST: Home Blood Pressure Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Efficacy of ONZETRA® Xsail® for the Acute Treatment of Episodic Migraine With or Without Aura in Adolescents
Status: TERMINATED
Conditions: Acute Migraine With or Without Aura
Interventions: DRUG: sumatriptan nasal powder|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fed Study of (Parlodel®) 2.5 mg Bromocriptine Mesylate Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BROMOCRIPTINE MESYLATE CAPSULES, USP 5 mg|DRUG: Parlodel® (bromocriptine mesylate) capsules, USP 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: 36-Months Clinical Evaluation of Preheated and Room Temperature Resin Composite
Status: COMPLETED
Conditions: Dental Leakage
Interventions: PROCEDURE: Preheating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 9-month Study to Assess the Efficacy of Ofatumumab on Microglia in Patients With Relapsing Forms of Multiple Sclerosis
Status: RECRUITING
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: Ofatumumab|DRUG: [F-18]PBR06
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zanubrutinib+Lenalidomide+R-ICE in Relapsed/Refractory DLBCL
Status: RECRUITING
Conditions: Diffuse Large B-cell Lymphoma Recurrent|Diffuse Large B Cell Lymphoma Refractory
Interventions: DRUG: ZR2-ICE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amlodipine as Adjuvant Treatment to Iron Chelation for Prevention of Cardiac Iron Overload in Thalassemia Patients
Status: UNKNOWN
Conditions: Beta-Thalassemia|Iron Overload
Interventions: DRUG: Amlodipine|DRUG: Deferasirox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of External Beam Radiation Therapy With and Without Hormonal Therapy to Treat Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Flutamide (Eulexin) and Lupron or Zoladex|RADIATION: External Beam Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficiency of the YEARS Algorithm Versus Computed Tomography Pulmonary Angiography Alone for Suspected Pulmonary Embolism in Patients With Malignancy
Status: RECRUITING
Conditions: Pulmonary Embolism|Embolism|Embolism and Thrombosis|Vascular Diseases|Cardiovascular Diseases|Lung Diseases|Respiratory Tract Diseases|Cancer|Diagnosis
Interventions: PROCEDURE: YEARS algorithm|PROCEDURE: CTPA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Using 'Guided-Discovery-Learning' to Optimize and Maximize Transfer of Surgical Simulation
Status: UNKNOWN
Conditions: Humans|Simulation Training|Problem-Based Learning|Clinical Competence|Education, Medical|Learning|Surgical Procedure, Unspecified
Interventions: OTHER: Discover followed by direct instruction [DD]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison of Arch Expansion Changes Between Passive Self-ligating and Conventional Brackets
Status: COMPLETED
Conditions: Orthodontic Appliance Complication
Interventions: DEVICE: Orthodontic Brackets|DEVICE: Orthodontic Brackets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety, Efficacy and Tolerability of Remote Ischemic Preconditioning as a Therapy to DMD
Status: UNKNOWN
Conditions: Duchenne Muscular Dystrophy (DMD)
Interventions: PROCEDURE: Remote Ischemic Preconditioning Training Apparatus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of the Medtronic Concerto™ Device
Status: COMPLETED
Conditions: Congestive Heart Failure, Atrial Arrhythmia, Atrial Tachyarrhythmia, Atrial Fibrillation
Interventions: DEVICE: Cardiac Resynchronization Therapy+Implantable Cardioverter Defibrillator
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimum Induction Therapy of Low-risk APL
Status: RECRUITING
Conditions: Acute Promyelocytic Leukemia|Induction Therapy|Oral
Interventions: DRUG: Etoposide|DRUG: Daunorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stress Multidetector Computed Tomography (MDCT) an New Diagnostic Tool for Myocardial Disease
Status: COMPLETED
Conditions: Coronary Artery Lesion
Interventions: OTHER: coronary dual source computed tomography (DSCT)|OTHER: myocardial single photon emission computed topography (SPECT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Bictegravir/Emtricitabine/Tenofovir Alafenamide Fixed Dose Combination in Adolescents and Children With Human Immunodeficiency Virus-1
Status: RECRUITING
Conditions: HIV-1 Infection
Interventions: DRUG: B/F/TAF (Adult Strength)|DRUG: B/F/TAF (Low Dose)|DRUG: B/F/TAF (TOS)|DRUG: B/F/TAF (TOS)|DRUG: B/F/TAF (TOS)|DRUG: B/F/TAF (TOS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Crown Supported by Short Implant Versus Standard Implant in Conjunction With Maxillary Sinus Floor Augmentation.
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Implant Failed
Interventions: PROCEDURE: 40 patients will be randomly allocated to short implants and standard implants in conjunction with MSFA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Nitrous Oxide for Pain Relief During Eye Exam in the Pre-term Infant
Status: COMPLETED
Conditions: Retinopathy of Prematurity
Interventions: OTHER: N2O|OTHER: oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Omega 3 Fatty Acids on Oxidative Stress in HIV Seropositive Patients
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: DRUG: omega 3 fatty acids|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tranexamic Acid During Upper GI Endoscopic Resection Procedures
Status: RECRUITING
Conditions: Gastric Polyp|Gastric Neoplasm|Duodenal Neoplasms|Esophageal Neoplasms
Interventions: DRUG: Tranexamic acid|DRUG: Epinephrine injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of SQJZ Herbal Mixtures on Non-motor Symptoms of Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson's Disease
Interventions: DRUG: SQJZ herbal mixtures|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Development and Pilot Testing of a New MR Imaging Protocol to Quantify Myeloma Disease Burden and Bone Loss
Status: COMPLETED
Conditions: Myeloma|Monoclonal Gammopathy of Undetermined Significance (MGUS)|Smouldering Myeloma
Interventions: OTHER: Diffusion Weighted Magnetic Resonance Imaging (DWMRI)|OTHER: DXA scan|OTHER: Bloods and urine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Inhaled Ciclesonide in Adult Patients With Asthma (BY9010/M1-125)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Ciclesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phase IIB Dose Ranging Study in Subjects With Moderate to Severe Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Clazakizumab|DRUG: Placebo (Matching with Clazakizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GIMEMA LAL 0496: High-dose Anthracycline in the Induction Regimen for the Treatment of Adult ALL.
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: High-dose anthracycline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of PD-1 and VEGFR-2 Blockade for Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Progress Free Survival (PFS) and Overall Survival (OS)
Interventions: DRUG: Bevacizumab Injection|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Using Virtual Reality Goggles on Fear and Pain Level During Vaccination in Children
Status: RECRUITING
Conditions: Fear of Pain|Fear|Virtual Reality|Pain|Vaccination|Children
Interventions: BEHAVIORAL: Virtual Reality Glasses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Promoting Youth Mental Health in Inequitable Contexts: Applying Participatory Action Research
Status: WITHDRAWN
Conditions: Youth Participatory Action Research|Youth Mental Health|Health Equity
Interventions: BEHAVIORAL: Youth Participatory Action Research-Mental Health Curriculum
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Iron and Zinc Absorption in Flakes Derived From Sprouted or Hydrothermally Processed Wheat
Status: NOT_YET_RECRUITING
Conditions: Iron Absorption|Zinc Absorption
Interventions: DIETARY_SUPPLEMENT: Processing of wheat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Local Ablative Therapy (LAT) in People With Non-Small Cell Lung Cancer (NSCLC)
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer|Metastatic Non Small Cell Lung Cancer|Nsclc|NSCLC Stage IV|Minimal Residual Disease|Non Small Cell Lung Cancer Metastatic
Interventions: PROCEDURE: Local ablative therapy|OTHER: Blood collection to assess for ctDNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Randomized, Case-control Study of Unilateral vs Bilateral Neck Dissection for cN0 Supraglottic Laryngeal Cancer
Status: UNKNOWN
Conditions: Laryngeal Neoplasms|Malignant Neoplasm of Supraglottis Primary|Neck Dislocation
Interventions: PROCEDURE: Unilateral Neck Dissection|PROCEDURE: Bilateral Neck Dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MDV3100 to Evaluate Safety, Tolerability, Pharmacokinetics and Efficacy of in Prostate Cancer Patients
Status: COMPLETED
Conditions: Prostate Cancer|Prostate Neoplasms|Castration Resistant Prostate Cancer (CRPC)
Interventions: DRUG: MDV3100
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autogenic Drainage Effect on Blood Gases and Prevention of Pulmonary Complication After Upper Abdominal Surgery
Status: COMPLETED
Conditions: Postoperative Complications
Interventions: PROCEDURE: autogenic drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Dabigatran Etexilate as Primary Treatment of Malignancy Associated Venous Thromboembolism
Status: UNKNOWN
Conditions: Venous Thromboembolism|Deep Vein Thrombosis|Pulmonary Embolism
Interventions: DRUG: Dabigatran etexilate|DRUG: Tinzaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Land and Water Physiotherapy on Motor Function in Parkinson's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson Disease
Interventions: OTHER: Physiotherapy on the ground|OTHER: Aquatic physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PD-L1 t-haNK, N-803 IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC
Status: RECRUITING
Conditions: Head and Neck Cancer|Head and Neck Squamous Cell Carcinoma|Metastatic Head and Neck Cancer|Recurrent Head and Neck Cancer|Metastatic Head-and-neck Squamous-cell Carcinoma|Recurrent Head and Neck Squamous Cell Carcinoma
Interventions: BIOLOGICAL: PD-L1 t-haNK|DRUG: Cetuximab|BIOLOGICAL: N-803
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Psychopathy be Prevented? Clinical, Neuroimaging and Genetic Data
Status: COMPLETED
Conditions: Psychopathic Personality Trait
Interventions: BEHAVIORAL: Trauma Focused-Cognitive Behavior Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Silver Modified and Conventional Atraumatic Restorative Treatment Modalities
Status: COMPLETED
Conditions: Dental Caries
Interventions: DRUG: Silver diamine Fluoride 38%|PROCEDURE: Conventional atraumatic restorative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neurodevelopmental Outcomes of Preterm Infants Treated for Pain Management With Repeated Doses of Sucrose 24%
Status: UNKNOWN
Conditions: Development
Interventions: DRUG: multiple doses of sucrose|DRUG: Formula or breast milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Nasal PYY3-36 and Placebo for Weight Loss in Obese Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Nasal Placebo|DRUG: Placebo Capsule|DRUG: PYY3-36|DRUG: PYY3-36|DRUG: PYY3-36|DRUG: Sibutramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neurobiological Principles Applied to the Rehabilitation of Stroke Patients
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Transcranial Magnetic Stimulation (TMS)|DRUG: Carbidopa-Levodopa|DRUG: Methylphenidate|DRUG: Amphetamine Sulfate|DRUG: Placebo|OTHER: Sham Transcranial Magnetic Stimulation (TMS)|OTHER: Transcranial Magnetic Stimulation (TMS) Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid
Status: COMPLETED
Conditions: Infantile Refsum's Disease|Zellweger Syndrome|Adrenoleukodystrophy|Peroxisomal Disorders|Cholestasis
Interventions: DRUG: Cholic Acids
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibrutinib, Rituximab, and Consolidation Chemotherapy in Treating Young Patients With Newly Diagnosed Mantle Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Blastoid Variant Mantle Cell Lymphoma|Mantle Cell Lymphoma|Pleomorphic Variant Mantle Cell Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Dexamethasone|DRUG: Doxorubicin|DRUG: Doxorubicin Hydrochloride|DRUG: Ibrutinib|OTHER: Laboratory Biomarker Analysis|DRUG: Methotrexate|BIOLOGICAL: Rituximab|DRUG: Vincristine|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carboplatin, Irinotecan, and Radiation Therapy Followed By Docetaxel in Treating Patients With Newly Diagnosed Stage III Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Carboplatin|DRUG: Docetaxel|DRUG: irinotecan hydrochloride|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcome, Recuperation and Hemodynamics in Aortic Stenosis
Status: UNKNOWN
Conditions: Aortic Valve Stenosis
Interventions: DIAGNOSTIC_TEST: CPET, 6MWT, QOL assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Platelet Function in Diabetic Patients With and Without Renal Impairment, and the Effects of Lipid Lowering Treatment
Status: COMPLETED
Conditions: Diabetes Mellitus|Impaired Renal Function
Interventions: DRUG: Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Argentina Brief Colonoscopy Difficulty Score (ABCD)
Status: COMPLETED
Conditions: Colorectal Cancer|Diagnoses Disease|Polyp of Colon|Adenoma Colon
Interventions: DIAGNOSTIC_TEST: Diagnostic high-definition white-light (HDWL) colonoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Evaluate the Phase III Clinical Trial of TQH2722 Injection in the Treatment of Moderate to Severe Atopic Dermatitis
Status: NOT_YET_RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: TQH2722 injection|DRUG: Placebo of TQH2722 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Translation and Validation of the COMM and ASI-SR
Status: RECRUITING
Conditions: Opioid Use|Opioid Use Disorder|Alcohol Use Disorder|Pain, Chronic
Interventions: DIAGNOSTIC_TEST: Current Opioid Misuse Measure (COMM)-SWE|DIAGNOSTIC_TEST: Oral fluid drug test|DIAGNOSTIC_TEST: PETh|DIAGNOSTIC_TEST: ASI-SR|DIAGNOSTIC_TEST: AUDIT|DIAGNOSTIC_TEST: DUDIT|DIAGNOSTIC_TEST: Brief Pain Inventory - BPI|DIAGNOSTIC_TEST: Patient Global Impression of Change PGIC|DIAGNOSTIC_TEST: GAD-7|DIAGNOSTIC_TEST: Patient Health questionnaire (PHQ9)|DIAGNOSTIC_TEST: DBS - cannabis test|OTHER: Sample of Blood for later DNA and immunological analysis in future studies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ellipsys Vascular Access System Post Market Surveillance (PS) Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Disease, End Stage|Kidney Disease, End-Stage|AV Fistula|Fistulas Arteriovenous
Interventions: DEVICE: Ellipsys Vascular Access System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Repetitive Transcranial Direct Current Stimulation (tDCS) on Chronic Pelvic Pain
Status: COMPLETED
Conditions: Chronic Pelvic Pain|Interstitial Cystitis|Post Traumatic Stress Disorder|Fibromyalgia|Irritable Bowel Syndrome
Interventions: PROCEDURE: tDCS|PROCEDURE: tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Ulcers Associated With Hammer, Mallet and Claw Toe Deformities in the Diabetic Patient Setting
Status: COMPLETED
Conditions: Diabetic Foot Ulcer|Hammer Toe|Mallet Toe|Claw Toe
Interventions: PROCEDURE: Flexor tenotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Bioequivalence of Vycavert (10 mg Hydrocodone Bitartrate/325 mg Acetaminophen) Compared to the Reference Drug Norco
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Vycavert|DRUG: Norco
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Growth Hormone and Chromosome 18q- and Abnormal Growth
Status: COMPLETED
Conditions: Loss of Chromosome 18q|Growth Hormone Deficiency
Interventions: DRUG: Nutropin AQ|PROCEDURE: Arginine and Clonidine Stimulation Testing|PROCEDURE: Growth Factors Laboratory Testing|PROCEDURE: Neuropsychological Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Sonocloud Device Combined With Nivolumab in Brain Metastases From Patients With Melanoma
Status: UNKNOWN
Conditions: Melanoma|Metastatic Melanoma
Interventions: DEVICE: SONOCLOUD|DRUG: Nivolumab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Follow-up of a Randomized Comparison of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Coronary Stenosis|Coronary Artery Disease
Interventions: OTHER: percutaneous coronary intervention vs bypass graft surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exparel as a Nerve Block for Severe Hand Pain
Status: TERMINATED
Conditions: CREST Syndrome|Peripheral Vascular Disease|Raynaud Disease|Scleroderma, Diffuse
Interventions: DRUG: liposomal bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AMEND-CRT: Mechanical Dyssynchrony as Selection Criterion for CRT
Status: RECRUITING
Conditions: Left Ventricular Dyssynchrony|Heart Failure|Cardiomyopathy, Dilated|Cardiac Remodeling, Ventricular
Interventions: DEVICE: Cardiac resynchronization therapy ON|DEVICE: Cardiac resynchronization therapy OFF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Misoprostol for Management of Women With an Incomplete Miscarriage
Status: UNKNOWN
Conditions: Miscarriage
Interventions: DRUG: misoprostol 800 µg|DRUG: misoprostol 400 µg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open Label Study of Romiplostim in Adult Thrombocytopenic Subjects With ITP
Status: COMPLETED
Conditions: Idiopathic Thrombocytopenic Purpura|Thrombocytopenia|Thrombocytopenic Purpura
Interventions: BIOLOGICAL: Romiplostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Role of FHL-1 and Myostatin in Intensive Care Unit Acquired Paresis (ICUAP)
Status: COMPLETED
Conditions: Intensive Care Unit Acquired Paresis|Muscle Wasting
Interventions: OTHER: Active muscle stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sterol and Isoprenoid Disease Research Consortium: Smith-Lemli-Opitz Syndrome
Status: TERMINATED
Conditions: Smith-Lemli-Opitz Syndrome
Interventions: DIETARY_SUPPLEMENT: Cholesterol supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrating Motivational Interviewing With Cognitive-behavioral Therapy
Status: COMPLETED
Conditions: Anxiety Disorders and Symptoms|Depression|Life Style
Interventions: BEHAVIORAL: Cognitive-behavioral therapy|BEHAVIORAL: Integrated motivational interviewing and cognitive-behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IV Methadone vs EXPAREL Erector Spinae Plane Blockade in Pediatric Subjects Undergoing Idiopathic Scoliosis Correction
Status: RECRUITING
Conditions: Adolescent Idiopathic Scoliosis|Juvenile Idiopathic Scoliosis
Interventions: DRUG: Methadone|DRUG: Liposomal bupivacaine (LB, Exparel)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Dose Ranging Escalation Study of Tramadol Hydrochloride in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tramadol HCl, 50 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Distal Radius Fractures in Patients Over 70 Years - Volar Plate or Plaster
Status: COMPLETED
Conditions: Distal Radius Fracture
Interventions: PROCEDURE: Volar plate|DEVICE: Synthes TCP volar plate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Luliconazole Solution, 10% in Subjects With Mild to Moderate Onychomycosis
Status: COMPLETED
Conditions: Distal and Lateral Subungual Onychomycosis
Interventions: DRUG: Luliconazole Solution, 10%|DRUG: Vehicle Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Kinesio Taping in Patients With Somatosensory Tinnitus
Status: COMPLETED
Conditions: Tinnitus, Subjective
Interventions: OTHER: Kinesio tape|OTHER: Shame tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Panitumumab and Pegylated Liposomal Doxorubicin for Platinum-Resistant Epithelial Ovarian Cancer With KRAS Wild-type
Status: COMPLETED
Conditions: Epithelial Ovarian Cancer
Interventions: DRUG: Pegylated liposomal doxorubicin|DRUG: Panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incisional Negative Pressure Wound Therapy for Prevention of Postoperative Infections Following Caesarean Section
Status: COMPLETED
Conditions: Surgical Wound Infection|Infection; Cesarean Section|Cesarean Section; Dehiscence|Complications; Cesarean Section|Complications; Cesarean Section, Wound, Dehiscence|Wound; Rupture, Surgery, Cesarean Section
Interventions: DEVICE: iNPWT|OTHER: Standard postoperative wound dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy, Safety, and Tolerability Study of Oral Ubrogepant in the Acute Treatment of Migraine
Status: COMPLETED
Conditions: Migraine, With or Without Aura
Interventions: DRUG: Ubrogepant|DRUG: Placebo-matching Ubrogepant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Osteopathic Manipulative Treatment Versus Therapeutic Exercises in Subjects With Chronic Non-specific Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Osteopathic Manipulative Treatment|OTHER: Exercise Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: In-line Mechanical Insufflation-Exsufflation in the Management of Ventilated Patients
Status: COMPLETED
Conditions: Ventilation Therapy; Complications|Airway Clearance Impairment
Interventions: DEVICE: Mechanical In-Line Inexsufflation|PROCEDURE: catheter suction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy Evaluation of Buckwheat Husk Extract on Cardiovascular Disease Risk Factors
Status: RECRUITING
Conditions: Cardiovascular Diseases
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Buckwheat husk extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study Comparing Phenylephrine HCL Extended Release Tablets 30 mg and Placebo (Study CL2007-07)(P07529)(COMPLETED)
Status: COMPLETED
Conditions: Blood Pressure|Human Experimentation
Interventions: DRUG: Phenylephrine Hydrochloride (HCl) Extended-Release tablets 30 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Development and Preliminary Trial of a Brief, Portable Health Intervention for Rural Sexual Minority Emerging Adults
Status: COMPLETED
Conditions: Depression|Suicidality|Substance Abuse|HIV|Minority Stress
Interventions: BEHAVIORAL: Expressive Writing (EW) Intervention|BEHAVIORAL: Self-Affirmation (SA) Intervention|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Feasibility of Remote Home Support Coaches (SOCIAL Study)
Status: COMPLETED
Conditions: Malnutrition|Isolation|Depression|Anxiety|Sedentary Behavior|Loneliness
Interventions: BEHAVIORAL: Telephone-based coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Metamizol for the Treatment of Neoplastic Chronic Pain
Status: TERMINATED
Conditions: Pain
Interventions: DRUG: Metamizole|DRUG: Diclofenac|DRUG: Diclofenac placebo|DRUG: Metamizole placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Intranasal Lidocaine to Treat Pediatric Migraine in the Emergency Department
Status: UNKNOWN
Conditions: Migraine
Interventions: DRUG: Lidocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oval Abutment Versus a Circular Abutment in Dental Implants in the Anterior Maxillae
Status: COMPLETED
Conditions: Dental Implants
Interventions: PROCEDURE: Oval section abutment of 2.9 mm|PROCEDURE: Circular section abutment of 3.3 mm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of OZURDEX® in Macular Edema Associated With Branch Retinal Vein Occlusion
Status: COMPLETED
Conditions: Macular Edema|Retinal Vein Occlusion
Interventions: DRUG: dexamethasone implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rates of Gastric Ulcer by Endoscopy in Knee Osteoarthritis Patients Receiving LT-NS001 Versus Naprosyn®
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: LT-NS001|DRUG: Naprosyn®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Randomized Pilot Study for the Treatment of Cutaneous Leiomyomas With Botulinum Toxin
Status: COMPLETED
Conditions: Cutaneous Leiomyomas|Hereditary Leiomyomatosis and Renal Cell Cancer
Interventions: BIOLOGICAL: Botulinum toxin type A|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nicotine Pharmacokinetics of THS Single Use of a Regular or a Menthol Stick Compared to CIG
Status: COMPLETED
Conditions: Smoking, Tobacco
Interventions: OTHER: P1R stick|OTHER: P1M stick|OTHER: CIG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Clinical Study to Investigate the Safety and Immunogenicity in Relation to Product Attributes of mRNA-1083 (Severe Acute Respiratory Syndrome Coronavirus 2 [SARS-CoV-2] and Influenza Vaccine)
Status: ACTIVE_NOT_RECRUITING
Conditions: Influenza|SARS-CoV-2
Interventions: BIOLOGICAL: mRNA-1083
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Intranasal Oxytocin for Frontotemporal Dementia
Status: ACTIVE_NOT_RECRUITING
Conditions: Frontotemporal Dementia
Interventions: DRUG: Syntocinon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laughter Yoga for Nursing Students Going Into Clinical Practice for the First Time
Status: COMPLETED
Conditions: Happiness|Laughter Yoga|Nursing Student|Stress|Clinical Practice
Interventions: BEHAVIORAL: laughter yoga|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ultrasound-Based Renal Sympathetic Denervation as Adjunctive Upstream Therapy During Atrial Fibrillation Ablation
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: renal denervation|DEVICE: Catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Irinotecan Liposome Injection Combined With 5-FU/LV± Immunotherapy in First-line Gemsitabine + Immunoprogressive Patients With Metastatic Biliary Tract Cancer
Status: RECRUITING
Conditions: Metastatic Biliary Tract Cancer
Interventions: DRUG: Irinotecan Hydrochloride Liposome Injection ；Fluorouracil ；Leucovorin；immunotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The XLIMUS-DES in Very Complex Lesions
Status: COMPLETED
Conditions: Coronary Atherosclerosis Due to Calcified Coronary Lesion|Chronic Total Occlusion of Coronary Artery
Interventions: DEVICE: XLimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Attention and Memory Treatments for Cancer Survivors
Status: COMPLETED
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: BEHAVIORAL: Endeavor: Computer-Based Cognitive Stimulation Intervention|BEHAVIORAL: Words!: Computer-Based Cognitive Stimulation Intervention|OTHER: Quality of Life (QOL) Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dynamic Estimation of Cardiac Output in the Operating Room
Status: UNKNOWN
Conditions: Interventional Radiology|Surgery|General Anesthesia|Organ Failure|Intensive Care|Hemodynamic Instability|Blood Pressure|Cardiac Output
Interventions: DEVICE: Trans-esophageal Doppler monitoring|DEVICE: MostCareUP Haemodynamic Monitor|DEVICE: Argos Cardiac Output (CO) Monitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Biotin Status in Pregnancy
Status: COMPLETED
Conditions: Biotin Deficiency
Interventions: DIETARY_SUPPLEMENT: biotin|DIETARY_SUPPLEMENT: biotin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Analysis of the Molecular Composition of Tubal Cilia in Patients With or Without Ectopic Pregnancy
Status: RECRUITING
Conditions: Salpingectomy|Hysterectomy|Primary Ciliary Dyskinesia|Ectopic Pregnancy
Interventions: PROCEDURE: salpingectomy|PROCEDURE: hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Goal Directed Fluid Therapy Versus Liberal Fluid Regimen in Primary Elective Hip Artrhoplasty
Status: TERMINATED
Conditions: Arthroplasty, Replacement, Hip|Anesthesia, Spinal|Hemodynamic Monitoring|Crystalloid Solutions
Interventions: DEVICE: Clearsight non invasive hemodynamic monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Retro-prospective Study of Total Hip Arthroplasty With EMPERION Modular Primary Stem in Australian Centres (HISTORIC)
Status: TERMINATED
Conditions: Osteoarthritis, Hip|Arthritis, Degenerative
Interventions: DEVICE: EMPERION Modular Primary Stem
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Improving Physical Activity Levels in the Arabic- Speaking Residents of East Jerusalem With Prediabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus
Interventions: BEHAVIORAL: Motivational Interview support and Dietitian support|BEHAVIORAL: Activity tracker plus usual care|BEHAVIORAL: Personalized physical activity prescription
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sensorimotor Training in Low-back Pain Rehabilitation
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Proprioceptive postural training|OTHER: Treadmill training|OTHER: Conventional physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of a Data-driven Technical Assistance System for Drug Prevention Coalitions
Status: ENROLLING_BY_INVITATION
Conditions: Substance Use|Adolescent Problem Behavior
Interventions: BEHAVIORAL: Coalition Check-Up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Two Psychosocial Therapies for Treating Children With Oppositional-Defiant Disorder
Status: COMPLETED
Conditions: Oppositional-Defiant Disorder
Interventions: BEHAVIORAL: Parent management training (PMT)|BEHAVIORAL: Collaborative problem solving (CPS)|BEHAVIORAL: Waitlist control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cisplatin, Irinotecan and Bevacizumab (PCA) Versus Docetaxel, Cisplatin, Irinotecan and Bevacizumab (TPCA) in Metastatic Esophageal and Gastric Cancer
Status: COMPLETED
Conditions: Esophageal Cancer|Gastric Cancer|Stomach Cancer
Interventions: DRUG: Bevacizumab|DRUG: Cisplatin|DRUG: Irinotecan|DEVICE: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT