pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Vaccine Therapy With or Without Sirolimus in Treating Patients With NY-ESO-1 Expressing Solid Tumors
Status: COMPLETED
Conditions: Anaplastic Astrocytoma|Anaplastic Oligoastrocytoma|Anaplastic Oligodendroglioma|Estrogen Receptor Negative|Estrogen Receptor Positive|Glioblastoma|Hormone-Resistant Prostate Cancer|Metastatic Prostate Carcinoma|Metastatic Renal Cell Cancer|Recurrent Adult Brain Neoplasm|Recurrent Bladder Carcinoma|Recurrent Breast Carcinoma|Recurrent Colorectal Carcinoma|Recurrent Esophageal Carcinoma|Recurrent Gastric Carcinoma|Recurrent Hepatocellular Carcinoma|Recurrent Lung Carcinoma|Recurrent Melanoma|Recurrent Ovarian Carcinoma|Recurrent Prostate Carcinoma|Recurrent Renal Cell Carcinoma|Recurrent Uterine Corpus Carcinoma|Resectable Hepatocellular Carcinoma|Sarcoma|Stage IA Breast Cancer|Stage IA Ovarian Cancer|Stage IA Uterine Corpus Cancer|Stage IB Breast Cancer|Stage IB Ovarian Cancer|Stage IB Uterine Corpus Cancer|Stage IC Ovarian Cancer|Stage II Uterine Corpus Cancer|Stage IIA Breast Cancer|Stage IIA Lung Carcinoma|Stage IIA Ovarian Cancer|Stage IIB Breast Cancer|Stage IIB Esophageal Cancer|Stage IIB Lung Carcinoma|Stage IIB Ovarian Cancer|Stage IIB Skin Melanoma|Stage IIC Ovarian Cancer|Stage IIC Skin Melanoma|Stage IIIA Breast Cancer|Stage IIIA Esophageal Cancer|Stage IIIA Lung Carcinoma|Stage IIIA Ovarian Cancer|Stage IIIA Skin Melanoma|Stage IIIA Uterine Corpus Cancer|Stage IIIB Breast Cancer|Stage IIIB Esophageal Cancer|Stage IIIB Ovarian Cancer|Stage IIIB Skin Melanoma|Stage IIIB Uterine Corpus Cancer|Stage IIIC Breast Cancer|Stage IIIC Esophageal Cancer|Stage IIIC Ovarian Cancer|Stage IIIC Skin Melanoma|Stage IIIC Uterine Corpus Cancer|Stage IV Bladder Urothelial Carcinoma|Stage IV Esophageal Cancer|Stage IV Ovarian Cancer|Stage IV Prostate Cancer|Stage IV Skin Melanoma|Stage IVA Uterine Corpus Cancer|Stage IVB Uterine Corpus Cancer
Interventions: BIOLOGICAL: DEC-205/NY-ESO-1 Fusion Protein CDX-1401|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IN-USE TOLERANCE STUDY UNDER DERMATOLOGICAL AND OPHTHALMOLOGICAL CONTROLS AND EFFICACY ASSESSMENT (Face Cream)
Status: COMPLETED
Conditions: Hypersensitive|Reactive and Intolerant Skin|Redness-prone Skin|Stinger Subjects
Interventions: OTHER: Cosmetic product
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cannabidiol Usage as an Adjunct Therapy for Crohn's Disease
Status: WITHDRAWN
Conditions: Crohn Disease|Inflammatory Bowel Diseases|Cannabis
Interventions: DRUG: Cannabidiol|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Post-Chemo Cognitive Impairment w/Transcranial Magnetic Stimulation (Chemobrain TMS)
Status: TERMINATED
Conditions: Chemo-brain
Interventions: DEVICE: Transcranial magnetic stimulation (TMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of HCP1904 in Healthy Male Volunteers.
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: HCP1904-1|DRUG: HCP1904-3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of 5-FU and LMW Heparin on the Rate of Retinal Redetachment After Silicone Oil Removal in Cases of PVR
Status: UNKNOWN
Conditions: Proliferative Vitreoretinopathy
Interventions: DRUG: low molecular weight heparin, 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Electroacupuncture for Mild-to-moderate Dry Eye
Status: RECRUITING
Conditions: Dry Eye
Interventions: DEVICE: Verum Electroacupuncture|DEVICE: Sham Electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Oral Ubrogepant in the Acute Treatment of Migraine During the Prodrome in Adult Participants
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Ubrogepant 100 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of AdhAQP1 on Salivary Flow in Patients Treated With Radiation for Head and Neck Cancer
Status: COMPLETED
Conditions: Parotid Salivary Dysfunction
Interventions: GENETIC: Gene Transfer|DRUG: AdhAQP1
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Brain and Behavior Correlates of Arm Rehabilitation
Status: COMPLETED
Conditions: Stroke, Cardiovascular
Interventions: BEHAVIORAL: Experimental group: CIMT group (Constraint-Induced Movement Therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial of Olanzapine in Patients With Manic or Mixed Episode of Bipolar I Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: olanzapine|DRUG: haloperidol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of ABLLS-R and Portage Guide in the Development of Receptive Language Skills Autism Spectrum Disorder.
Status: COMPLETED
Conditions: Autism Spectrum Disorders|Non-verbal Learning Disorder
Interventions: OTHER: Portage Guide Protocol|OTHER: ABLLS-R protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Open vs Laparoscopic Repair of Perforated Peptic Ulcer
Status: NOT_YET_RECRUITING
Conditions: Perforated Peptic Ulcer
Interventions: PROCEDURE: open repair(exploration)|PROCEDURE: abdominal laparoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigate the Effect of AZD1656 on the Pharmacokinetics of Pioglitazone and Vice Versa in Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: AZD1656|DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-202
Status: RECRUITING
Conditions: Neoplasms, Head and Neck
Interventions: DRUG: Dostarlimab|DRUG: Belrestotug|DRUG: Nelistotug|DRUG: GSK4381562
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Progression of Health Related Quality of Life of Patients Waiting for Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Arthroplasty|Knee Arthroplasty, Total|Knee Replacement, Total|Replacement, Total Knee|Total Knee Replacement|Health-Related Quality Of Life|Life Quality|Osteoarthritis Of Knee
Interventions: OTHER: Health Quality of Life Questionnaire Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence of Two Different Generations of Drug Product of Dabigatran Etexilate Following Oral Administration in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Dabigatran etexilate generation I|DRUG: Dabigatran etexilate generation II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intraneural Facilitation Therapy on Diabetic Patients With Peripheral Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathy
Interventions: OTHER: Intraneural Facilitation|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Predictive Model on ED Physician Assessments of Patient Disposition
Status: NOT_YET_RECRUITING
Conditions: Patient Outcome Assessment
Interventions: DIAGNOSTIC_TEST: Baseline model|DIAGNOSTIC_TEST: Fairness-aware model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Clarithromycin, Amoxicillin, and Metronidazole Based Regimens to Treat Helicobacter Pylori Infections in Colombia
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Clarithromycin, Metronidazole, Amoxicillin (+Omeprazole)|DRUG: Clarithromycin, Amoxicillin, Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Observational Prospective Study Measuring the Impact of the Use of a Hypnotic Script Associated With Virtual Reality on the Pain of the Child's Sickle Cell During a Vaso-occlusive Crisis
Status: UNKNOWN
Conditions: Sickle Cell Disease
Interventions: DEVICE: Virtual Reality
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vitamin D and Mammographic Breast Density
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Brief Patient-Controlled Intervention for a Symptom Cluster in Advanced Cancer
Status: COMPLETED
Conditions: Pain|Fatigue|Sleep Disturbance|Cancer
Interventions: BEHAVIORAL: Cognitive-Behavioral Intervention|OTHER: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Negative Symptoms in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: OTHER: Repetitive transcranial magnetic stimulation|OTHER: Sham repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Respiratory Dynamics During Birth Stabilization in Preterm Infants Less Than 32+6/7 Weeks Gestation
Status: COMPLETED
Conditions: Infant, Premature
Interventions: OTHER: RFM (device) Visible
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cardiorespiratory Fitness in Children and Adolescents After Cancer Treatment.
Status: RECRUITING
Conditions: All Types of Pediatric Cancer
Interventions: BEHAVIORAL: Experimental: moderate to high-intensity exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Cutaneous Neurofibroma
Status: COMPLETED
Conditions: Cutaneous Neurofibroma|Neurofibromatosis Type 1|Optic Nerve Glioma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Selumetinib Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of PN-232 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: PN-232|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Pharmacokinetics and the Safety of ID14009 Compared to Coadministration of ID1805 With ID1803 in Healthy Adult Volunteers
Status: UNKNOWN
Conditions: Dyslipidemias|Hypertension
Interventions: COMBINATION_PRODUCT: ID140009|COMBINATION_PRODUCT: ID1803+ID1805
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of SNS01-T in Relapsed or Refractory B Cell Malignancies (Multiple Myeloma, B Cell Lymphoma, or Plasma Cell Leukemia (PCL)
Status: UNKNOWN
Conditions: Multiple Myeloma|Multiple Myeloma in Relapse|Mantle Cell Lymphoma in Relapse|Diffuse Large B Cell Lymphoma in Relapse|Other B Cell Lymphoma in Relapse|Plasma Cell Leukemia
Interventions: BIOLOGICAL: SNS01-T|BIOLOGICAL: SNS01-T|BIOLOGICAL: SNS01-T|BIOLOGICAL: SNS01-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Pulmonary Valve Replacement Methods to Treat Tetralogy of Fallot
Status: COMPLETED
Conditions: Tetralogy of Fallot|Pulmonary Valve Insufficiency|Ventricular Dysfunction, Right
Interventions: PROCEDURE: PVR plus RV remodeling|PROCEDURE: Standard PVR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of DTRI-031 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers|Pharmacokinetics|Pharmacodynamics
Interventions: DRUG: DTRI-031|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Retrospective Database Study: Survival of Direct Composite Restorations Placed Under General Anesthesia in Adult Patients With Intellectual and/or Physical Disabilities and Risk Factors for Repeated Dental Treatment in General Anesthesia
Status: COMPLETED
Conditions: Intellectual and/or Physical Disabilities|Dental Treatment Under General Anesthesia
Interventions: OTHER: No patient treatment is associated with the study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Postoperative Pain After Using Er,Cr,YSGG Lazer Irradiation During Root Canal Treatment
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DEVICE: Er,Cr:YSGG Laser|OTHER: Sodium hypochlorite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Evaluation Of BW430C (Lamotrigine) In Bipolar I Disorder- Long-term Extension Of Study SCA104779 (NCT00550407) -
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: BW430C (lamotrigine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Squid Liquid Embolic Agent for the Embolization of Abdominopelvic Arterial Bleeding Syndrome (SQUIDperi Study)
Status: UNKNOWN
Conditions: Arterial Bleed|Abdominal|Embolism Arterial|Pelvic Bleeding
Interventions: DEVICE: SQUIDperi
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Oral Supplementation With AM3, Hesperidin and Spermidine Supplementation on Immunity Response and Biological Age.
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Inmunoferon|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Baduanjin Program Effect on Geriatric Functional Dyspepsia
Status: RECRUITING
Conditions: Functional Dyspepsia
Interventions: BEHAVIORAL: baduinjuin activities|OTHER: pantoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Two Weeks of Low Molecular Weight Heparin for Distal Vein Thrombosis
Status: UNKNOWN
Conditions: Venous Thrombosis|Pulmonary Embolism
Interventions: DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plant Sterols on Cardiovascular Markers, Microbiota and Sterol Metabolism (Cardiofoodsterol)
Status: RECRUITING
Conditions: Cardiovascular Diseases|Hypercholesterolemia|Prediabetic State|Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: Plant sterols 2g/day|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pre Operative Trastuzumab in Operable Breast Cancer
Status: RECRUITING
Conditions: Carcinoma Breast Stage I|HER2 Positive Breast Cancer
Interventions: DRUG: Trastuzumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of GLP-1 on Insulin-dose, Risk of Hypoglycemia and Gastric Emptying Rate in Patients With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Liraglutide|DRUG: Liraglutide|OTHER: continuous insulin therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Plus Rituximab Combination for Adult Lymphoblastic Leukemia (B-ALL) and Burkitt's Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Burkitt Lymphoma|B-ALL
Interventions: DRUG: Chemotherapy-Rituximab combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BRCA1 and BRCA2 Mutation in Romanian Population: a Study of Genotype - Phenotype Correlation at Diagnosis With Prospective Disease Outcome and Survival
Status: COMPLETED
Conditions: To Determine the Prevalence, Penetrance of BRCA1 and BRCA2 Mutations in Romanian Womens With Breast or Ovarian Cancer
Interventions: GENETIC: NGS BRCA 1 and BRCA 2 full sequencing|GENETIC: Multiplex ligation-dependent probe amplification (MPLA) BRCA1 BRCA2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: STI Screening as a Combined HIV Prevention Platform for MSM in Peru
Status: COMPLETED
Conditions: Gonorrhoea of Rectum|Chlamydia of Rectum|HIV Infections
Interventions: BEHAVIORAL: PCC|BEHAVIORAL: Traditional Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability During Open-label Treatment With LCZ696 in Patients With CHF and Reduced Ejection Fraction
Status: COMPLETED
Conditions: Chronic Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: LCZ696
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin Type A for the Treatment of Patients With Idiopathic Overactive Bladder With Urinary Incontinence
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: BIOLOGICAL: onabotulinumtoxinA|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: De-novo Initiation of Letermovir vs Valganciclovir for Cytomegalovirus Prophylaxis in AA Kidney Trans Recip
Status: RECRUITING
Conditions: Kidney Transplant; Complications|CMV
Interventions: DRUG: Letermovir 480 mg once daily|OTHER: Historical/Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relationship Training for Children With Autism and Their Peers
Status: COMPLETED
Conditions: Autism|Autistic Disorder
Interventions: BEHAVIORAL: Social skills training targeting children with autism|BEHAVIORAL: Social skills training of peers without autism|BEHAVIORAL: Combination treatment of social skills/education about autism|BEHAVIORAL: Usual training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Randomized, Open Labeled Clinical Trial to Compare the Effectiveness of Amlodipine/Valsartan vs Hydrochlorothiazide/Telmisartan on Glucose Tolerance in Patients With Hypertension With Metabolic Syndrome
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: amlodipine/valsartan|DRUG: hydrochlorothiazide/telmisartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Different Images Watched With Virtual Reality During Phlebotomy
Status: COMPLETED
Conditions: Pain Management|Anxiety Management|Blood Donation|Virtual Reality
Interventions: OTHER: group watching hot environment image|OTHER: group watching cold environment image
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ketamine and Scopolamine Infusions for Treatment-resistant Major Depressive Disorder
Status: WITHDRAWN
Conditions: Major Depressive Disorder
Interventions: DRUG: Ketamine|DRUG: Scopolamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D in Active Tuberculosis (TB) Study
Status: WITHDRAWN
Conditions: Tuberculosis
Interventions: DRUG: Vitamin D3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral N-acetylcysteine for Retinitis Pigmentosa
Status: RECRUITING
Conditions: Retinitis Pigmentosa
Interventions: DRUG: N-acetylcysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of ATR-002
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: ATR-002 MEK Inhibitor|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Acupuncture and Laser Acupuncture for Carpal Tunnel Syndrome
Status: ENROLLING_BY_INVITATION
Conditions: Carpal Tunnel Syndrome|Acupuncture|Laser Acupuncture
Interventions: PROCEDURE: manual acupuncture|DEVICE: laser acupuncture|DEVICE: sham laser acupuncture|DEVICE: wrist splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Elagolix for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women
Status: COMPLETED
Conditions: Uterine Fibroids
Interventions: DRUG: Elagolix|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Ziv-aflibercept in Combination With Capecitabine/Oxaliplatin (XELOX) Chemotherapy in the Front-Line Treatment of Patients With Metastatic Colorectal Cancer
Status: WITHDRAWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Arm A|DRUG: Arm B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stage II-IIIa Urothelial Cancer Randomizing Pre-operative Nivolumab With or Without Relatlimab
Status: RECRUITING
Conditions: Urologic Neoplasms|Urogenital Neoplasms|Neoplasms by Site|Neoplasms|Female Urogenital Diseases|Female Urogenital Diseases and Pregnancy Complications|Urogenital Diseases|Urinary Bladder Diseases|Male Urogenital Diseases|Urinary Bladder Neoplasm|Antineoplastics Toxicity
Interventions: DRUG: Nivolumab|DRUG: Relatlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare the Efficacy of Surgery Combined With Systemic Therapy and Pure Systemic Therapy in Breast Cancer Patients
Status: WITHDRAWN
Conditions: Stage IV Breast Cancer
Interventions: COMBINATION_PRODUCT: surgery combined with systemic therapy|OTHER: systemic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tailored Therapy for Helicobacter Pylori Rescue Treatment
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: esomeprazole|DRUG: bismuth Potassium Citrate|DRUG: amoxicillin|DRUG: clarithromycin|DRUG: metronidazole|DRUG: levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardioprotective Properties of Vegan Burger
Status: RECRUITING
Conditions: Cardiometabolic Health
Interventions: BEHAVIORAL: Conventional burger|BEHAVIORAL: Vegan burger
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Strawberries on Blood Cholesterol.
Status: COMPLETED
Conditions: Hyper-LDL-cholesterolemia|Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: strawberries|OTHER: Control powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: X-396 (Ensartinib) Capsules in ALK-Positive NSCLC Patients With Brain Metastases
Status: UNKNOWN
Conditions: Lung Cancer, Nonsmall Cell|Brain Metastases
Interventions: DRUG: X-396(Ensartinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect on Fluid Balance After Cardiac Surgery After Use of Two Different Priming Protocols
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DRUG: Tetraspan|DRUG: acetated Ringer's solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 5-year Follow-up After a Single Dose Acellular Pertussis Vaccination
Status: COMPLETED
Conditions: Pertussis
Interventions: BIOLOGICAL: Biological/Vaccine: Pertagen (aP BioNet)|BIOLOGICAL: Biological/Vaccine: Boostagen (TdaP BioNet)|BIOLOGICAL: Biological/Vaccine: Adacel
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Psychological Treatment of Depression in Women With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia|Depressive Symptoms
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Personal Construct Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GLPG0492 Pharmacodynamics
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG0492|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prehospital Non-invasive Ventilation for Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Status: RECRUITING
Conditions: COPD Exacerbation|COPD Exacerbation Acute|Noninvasive Ventilation|Emergency Medical Services
Interventions: OTHER: Non-invasive ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Gemcitabine or Gemcitabine + Enzastaurin in Participants With Advanced or Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Neoplasm
Interventions: DRUG: enzastaurin|DRUG: gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Picosecond Laser for Ttreatment of Benign Pigmented Lesions
Status: COMPLETED
Conditions: Benign Pigmented Lesions
Interventions: DEVICE: GentleMax system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Investigate Efficacy and Safety of NT 201 Injections Compared With Placebo Injections in Participants Aged 18 Years and Older With Chronic Nerve Pain After Shingles or Nerve Injury
Status: RECRUITING
Conditions: Moderate to Severe Chronic Peripheral Neuropathic Pain (PNP) Due to Postherpetic Neuralgia (PHN) or Peripheral Nerve Injury
Interventions: BIOLOGICAL: IncobotulinumtoxinA|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study to Assess Safety, Tolerability and Efficacy of Once Weekly SC Pemziviptadil (PB1046) in Subjects With Symptomatic PAH
Status: TERMINATED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Pemziviptadil (PB1046)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Research of ROBO1 Specific BiCAR-NK/T Cells on Patients With Malignant Tumor
Status: UNKNOWN
Conditions: Malignant Tumor
Interventions: BIOLOGICAL: BiCAR-NK/T cells (ROBO1 CAR-NK/T cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trevisio Post-Approval Study
Status: RECRUITING
Conditions: PFO - Patent Foramen Ovale|ASD - Atrial Septal Defect|VSD - Muscular Ventricular Septal Defect|PIVSD - Post Infarct Muscular Ventricular Septal Defect
Interventions: DEVICE: Amplatzer™ Trevisio™ Intravascular Delivery System using Amplatzer PFO Occluder, ASO or Amplatzer Cribriform Occluder|DEVICE: Amplatzer™ Trevisio™ Intravascular Delivery System using Amplatzer Muscular VSD Occluder or Amplatzer Post-Infarct Muscular VSD Occluder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Innovation of 3D Printing for Preoperative Planning in Hip Preservation Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Femoro Acetabular Impingement
Interventions: OTHER: 3D Print + Conventional imaging|OTHER: Conventional imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Severe Osteogenesis Imperfecta by Allogeneic Bone Marrow Transplantation
Status: COMPLETED
Conditions: Osteogenesis Imperfecta
Interventions: OTHER: Bone Marrow Cell Transplantation|RADIATION: Irradiation, Total Body|DRUG: Cyclophosphamide|DRUG: Cyclosporin|PROCEDURE: Mesenchymal Stem Cell Transplantation|DRUG: Busulfan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Scheimpflug Versus Placido-disc System in Evaluation of Corneal Higher-Order Aberrations
Status: NOT_YET_RECRUITING
Conditions: Corneal Higher-order Aberrations
Interventions: DEVICE: placido-based topographer (wavelight allegro topolyzer vario) and scheimpflug -based (Oculus Pentacam )
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Improving Colorectal Cancer Screening for Diverse Hispanics in Urban Primary Care
Status: COMPLETED
Conditions: Colorectal Cancer Screening
Interventions: BEHAVIORAL: Best clinical practices plus culturally targeted print materials|BEHAVIORAL: Best clinical practices plus standard print materials|BEHAVIORAL: Best clinical practices alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Smoker-to-Smoker (S2S) Peer Marketing and Messaging to Disseminate Tobacco Interventions
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Recommender CTHC|BEHAVIORAL: Standard CTHC|OTHER: Peer Recruitment|OTHER: Standard Online Recruitment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Pharmacokinetics of Tacrolimus in Stable Pediatric Allograft Recipients Converted From Prograf® to Advagraf®
Status: ACTIVE_NOT_RECRUITING
Conditions: Intestine Transplantation|Kidney Transplantation|Lung Transplantation|Liver Transplantation|Heart Transplantation
Interventions: DRUG: Tacrolimus|DRUG: Tacrolimus prolonged release
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of RV1729 for up to 28 Days
Status: COMPLETED
Conditions: Asthma|Healthy Volunteers
Interventions: DRUG: RV1729 single dose|DRUG: RV1729 matching placebo single dose|DRUG: RV1729 14 day repeat dose|DRUG: RV1729 matching placebo 14 day repeat dose|DRUG: RV1729 28 day repeat dose|DRUG: RV1729 matching placebo 28 day repeat dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risk Assessment Evaluation for Identifying Participants at High Risk for Stomach Cancer
Status: RECRUITING
Conditions: Gastric Carcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Breath Test|PROCEDURE: Esophagogastroduodenoscopy|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effect of Fermented Soy Based Product on Cardiometabolic Risk Factors
Status: COMPLETED
Conditions: Cardiovascular Risk Factor|Heart Diseases|Inflammation
Interventions: DIETARY_SUPPLEMENT: Q CAN PLUS|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Naturalistic Study of Microdosing With Psilocybin
Status: COMPLETED
Conditions: Cognitive Change|Creativity|Mood Change|Sleep
Interventions: DRUG: Psilocybin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sitagliptin in Combination With Beidougen Capsule for Type 2 Diabetes
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: Sitagliptin|DRUG: Sitagliptin combined with Beidougen capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Fluid Regimen on Acute Kidney Injury
Status: NOT_YET_RECRUITING
Conditions: Nephrectomy|Acute Kidney Injury|Fluid Therapy
Interventions: DIAGNOSTIC_TEST: Restrictive|DIAGNOSTIC_TEST: Liberal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Mechanisms of Belatacept Effect on Alloimmunity and Antiviral Response After Kidney Transplantation (BMS IM 103-309)
Status: COMPLETED
Conditions: Renal Transplant Rejection
Interventions: DRUG: Belatacept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 1/2-Dopaminergic Dysfunction in Late-Life Depression (The D3 Study)
Status: TERMINATED
Conditions: Depression|Cognitive Impairment|Gait Impairment
Interventions: DRUG: Carbidopa/levodopa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of NAC on the Hematopoietic Reconstitution After Haploidentical Hematopoietic Stem Cell Transplantation
Status: COMPLETED
Conditions: Haploidentical Hematopoietic Stem Cell Transplantation
Interventions: DRUG: N-acetyl-L-cysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Compare the Pharmacokinetics and Safety of a Fixed Dose Combination of Fimasartan/Amlodipine/Rosuvastatin
Status: COMPLETED
Conditions: Hypertension, Hyperlipidemia
Interventions: DRUG: Fimasartan/Amlodipine combination drug, Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and Safety Study of HYLENEX Recombinant-Augmented Subcutaneous Ceftriaxone Administration
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: SC HYLENEX and Ceftriaxone|DRUG: SC Placebo and Ceftriaxone|DRUG: IV Ceftriaxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Patients With Recently Exacerbated Schizophrenia With Paliperidone Palmitate
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Paliperidone palmitate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Effects of Motor, Sensory and Cognitive Exercises on Falls Prevention
Status: UNKNOWN
Conditions: Motor, Sensory, Cognition, Older, Falls, Balance Ability, Randomized Controlled Trial, Task-oriented Approach
Interventions: BEHAVIORAL: falls-prevention programs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PCI and Renal Denervation in Hypertensive Patients With Acute Coronary Syndromes
Status: UNKNOWN
Conditions: Hypertension|Acute Myocardial Infarction
Interventions: PROCEDURE: Renal denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Alcohol Use and Sexual Dysfunction in Survivors of Sexual Trauma
Status: RECRUITING
Conditions: Alcohol Use, Unspecified|Sexual Dysfunction|Sexual Assault
Interventions: BEHAVIORAL: AWARE|BEHAVIORAL: General Health Promotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prazosin Treatment for Combat Trauma PTSD (Post-Traumatic Stress Disorder) Nightmares and Sleep Disturbance
Status: COMPLETED
Conditions: Stress Disorder, Post-Traumatic
Interventions: DRUG: Prazosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of MK-0431D (a Fixed-dose Combination of Sitagliptin and Simvastatin) for the Treatment of Participants With Type 2 Diabetes Mellitus (T2DM) With Inadequate Glycemic Control on Metformin Monotherapy (MK-0431D-266)
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin/Simvastatin FDC|DRUG: Sitagliptin|DRUG: Simvastatin|DRUG: Placebo to sitagliptin|DRUG: Placebo to simvastatin|DRUG: Placebo to Sitagliptin/Simvastatin FDC|DRUG: Metformin|DRUG: Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Feeding Tolerance in Infants Fed Cow Milk Formula
Status: COMPLETED
Conditions: Healthy Term Infants Solely Formula Fed
Interventions: OTHER: Enfamil LIPIL with iron|OTHER: Good Start Supreme with DHA and ARA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Atezolizumab Plus Bevacizumab Alone or Combined With External Beam Radiotherapy for HCC With Macrovascular Invasion
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Hepatocellular Cancer|Hepatocellular Carcinoma Non-resectable|Hepatocellular Carcinoma Stage IV|Liver Cancer
Interventions: RADIATION: Atezolizumab plus bevacizumab, combined EBRT to vascular invasion|DRUG: Atezolizumab plus bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Clinical Pharmacology Study of TAK-233 in Healthy Subjects
Status: COMPLETED
Conditions: Clinical Pharmacology
Interventions: DRUG: TAK-233|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ecopipam Tablets to Study Tourette's Disorder in Children, Adolescents and Adults
Status: RECRUITING
Conditions: Tourette Disorder
Interventions: DRUG: Ecopipam Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of RO4917838 in Patients With Sub-optimally Controlled Symptoms of Schizophrenia (NN25307)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Placebo|DRUG: RO4917838|DRUG: RO4917838
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hypofractionated Radiation Therapy in Treating Patients With Stage 0-IIB Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Ductal Breast Carcinoma In Situ|Invasive Breast Carcinoma|Stage 0 Breast Cancer|Stage I Breast Cancer|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage II Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer
Interventions: RADIATION: Hypofractionated Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S-Asenosyl-L-Methionine vs Placebo for Osteoarthritis of the Hands
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis Hand
Interventions: DRUG: S-Adenosyl-L-Methionine (Sam-E)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Compare Safety and Efficacy of BIBF 1120 Versus Sunitinib.
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: BIBF 1120|DRUG: sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In Vivo Assessment of Silver Biomaterial Nano-Toxicity
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 10ppm Oral Silver Particle|DRUG: 32ppm Oral Silver Particle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Erbitux (Cetuximab) Given Alone to Patients With EGFR-Negative Metastatic Colon or Rectal Cancer That is Refractory to Chemotherapy
Status: COMPLETED
Conditions: Colorectal Neoplasms|Metastases|Neoplasm
Interventions: BIOLOGICAL: cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Entinostat, Nivolumab, and Ipilimumab in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery or Locally Advanced or Metastatic HER2-Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Breast Adenocarcinoma|Invasive Breast Carcinoma|Malignant Solid Neoplasm
Interventions: PROCEDURE: Biopsy|OTHER: Blood Sample|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|DRUG: Entinostat|BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab|OTHER: Pharmacogenomic Study|OTHER: Pharmacological Study|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography (PET) Imaging of Thrombosis
Status: RECRUITING
Conditions: Atrial Fibrillation|COVID-19|Cancer|Thrombosis
Interventions: DRUG: [64Cu]FBP8|DEVICE: PET/MR|PROCEDURE: Blood Collection|PROCEDURE: Electrocardiogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nutritional Education Program for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Status: NOT_YET_RECRUITING
Conditions: Fatty Liver, Nonalcoholic|Diet, Healthy
Interventions: BEHAVIORAL: Mediterranean-diet intervention group|BEHAVIORAL: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Port Laparoscopic Cholecystectomy Versus Four Port Laparoscopic Cholecystectomy: Impact on Postoperative Pain
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DEVICE: Single port laparoscopic cholecystectomy SINGLE SITE LAPAROSCOPY ACCESS SYSTEM (Johnson & Johnson Medical Spa)|PROCEDURE: Four port laparoscopic cholecystectomy surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT