pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Intramuscular Injection of Human Chorionic Gonadotropin in Frozen Embryo Transfer Cycles
Status: COMPLETED
Conditions: Embryo Implantation
Interventions: DRUG: The effect of intramuscular injection of triple doses of human chorionic gonadotropin in frozen embryo transfer cycles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intermittent Oro-esophageal Tube Feeding on Dysphagic Stroke Survivors
Status: WITHDRAWN
Conditions: Stroke
Interventions: BEHAVIORAL: comprehensive rehabilitation therapy|DEVICE: Intermittent Oro-esophageal Tube Feeding|DEVICE: Nasogastric Tube Feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of the Safety, Tolerability, and Pharmacokinetics of Dolutegravir in Neonates Exposed to HIV-1
Status: RECRUITING
Conditions: HIV
Interventions: DRUG: Dolutegravir 0.5 mg/kg oral suspension|DRUG: Dolutegravir 5 mg Dispersible Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: rAd-p53 Gene Therapy for Advanced Oral and Maxillofacial Malignant Tumors
Status: UNKNOWN
Conditions: Advanced Oral and Maxillofacial Malignant Tumors
Interventions: DRUG: p53 gene with surgery|PROCEDURE: surgery|DRUG: p53 with chemotherapy|DRUG: p53 gene therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
Status: RECRUITING
Conditions: Chronic Kidney Disease|Proteinuria|Children
Interventions: DRUG: Finerenone (Kerendia, BAY94-8862)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Cross Linked Hyaluronan Gel After Deep Infiltrating Endometriosis Surgery
Status: COMPLETED
Conditions: Endometriosis|Adhesion|Quality of Life|Surgery
Interventions: DRUG: 40 cc HyaRegen NCH gel|DRUG: 40 cc sterile saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lenalidomide, Umbralisib, and Ublituximab for the Treatment of Relapsed or Refractory Indolent Non-Hodgkin Lymphoma or Mantle Cell Lymphoma
Status: WITHDRAWN
Conditions: Recurrent B-Cell Non-Hodgkin Lymphoma|Recurrent Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue|Recurrent Follicular Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3a Follicular Lymphoma|Recurrent Lymphoplasmacytic Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Nodal Marginal Zone Lymphoma|Recurrent Splenic Marginal Zone Lymphoma|Recurrent Waldenstrom Macroglobulinemia|Refractory B-Cell Non-Hodgkin Lymphoma|Refractory Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue|Refractory Follicular Lymphoma|Refractory Grade 1 Follicular Lymphoma|Refractory Grade 2 Follicular Lymphoma|Refractory Grade 3a Follicular Lymphoma|Refractory Lymphoplasmacytic Lymphoma|Refractory Mantle Cell Lymphoma|Refractory Marginal Zone Lymphoma|Refractory Nodal Marginal Zone Lymphoma|Refractory Splenic Marginal Zone Lymphoma|Refractory Waldenstrom Macroglobulinemia
Interventions: DRUG: Lenalidomide|BIOLOGICAL: Ublituximab|DRUG: Umbralisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbial Transplantation Non-Small Cell Lung Cancer and Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer Metastatic|Advanced Melanoma
Interventions: COMBINATION_PRODUCT: FMT + ICI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caffeine, Genetic Variation and Athletic Performance
Status: UNKNOWN
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Caffeine 2mg|DIETARY_SUPPLEMENT: Caffeine 4 mg|DIETARY_SUPPLEMENT: Caffeine 0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Effect of Intravenous (IV) Infusions of Risankizumab on Pharmacokinetics of Cytochome P450 Substrates in Adult Participants With Moderately to Severely Active Ulcerative Colitis or Crohn's Disease
Status: COMPLETED
Conditions: Ulcerative Colitis (UC)|Crohn's Disease
Interventions: DRUG: Risankizumab|DRUG: Cytochrome P450 (CYP) Substrates
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Immunotherapy Combined With Stereotactic Radiation Therapy Boost in the Treatment of HER2-negative Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Keytruda|RADIATION: Preoperative radiation therapy|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Ototoxicity in NTM Patients Treated With IV Amikacin
Status: NOT_YET_RECRUITING
Conditions: Ototoxicity, Drug-Induced
Interventions: DRUG: ORC-13661|DRUG: ORC-13661|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Understanding "Heparin Resistance" in Cardiac Surgery
Status: COMPLETED
Conditions: Cardiopulmonary Bypass|Altered Heparin Response
Interventions: DRUG: Heparin|DRUG: ATryn
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day
Status: COMPLETED
Conditions: Tobacco Use Disorder
Interventions: OTHER: Very low nicotine content (VLNC) cigarettes and nicotine replacement therapy (NRT)|OTHER: Reduce cigarettes per day (CPD) with nicotine replacement therapy (NRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison Between Early Excision and Grafting Versus Dressing and Delayed Grafting in Deep Burn Mangement.
Status: UNKNOWN
Conditions: Burns
Interventions: PROCEDURE: Excision and Grafting|PROCEDURE: dressing then delayed grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Effect of Itraconazole (a CYP3A4 Inhibitor) on the Pharmacokinetics of AZD9291, in Patients With EGFR Positive Non-small Cell Lung Cancer. Patients Will be Chosen From Those Who Have Already Been Prescribed an EGFR TKI Medicine (Such as Iressa or Tarceva)
Status: COMPLETED
Conditions: Advanced Non Small Cell Lung Cancer|Advanced (Inoperable) Non Small Cell Lung Cancer
Interventions: PROCEDURE: Pharmacokinetic sampling|DRUG: AZD9291|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: OTHER
Clinical trial: Measurement of the Hippocampal Theta Rhythm From the Outer Ear Canal
Status: RECRUITING
Conditions: Anxiety
Interventions: DRUG: Buspirone 10 Mg Oral Tablet|DRUG: Triazolam 0.25 MG Oral Tablet|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Veliparib With or Without Carboplatin in Treating Patients With Stage III or IV Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Locally Advanced Breast Carcinoma|Metastatic Breast Carcinoma|Unresectable Breast Carcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Carboplatin|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Hydromorphone on Responses to Verbal Tasks
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 2 mg hydromorphone|DRUG: 1000 mg Acetaminophen|DRUG: 4 mg hydromorphone|DRUG: dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of SHR-1905 Injection in Patients With Chronic Rhinosinusitis With Nasal Polyps
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Rhinosinusitis With Nasal Polyps
Interventions: DRUG: SHR-1905 Injection|DRUG: SHR-1905 Placebo Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of Topical Anesthesia in Children
Status: COMPLETED
Conditions: Skin Lacerations
Interventions: DRUG: LET gel (lidocaine 4%, epinephrine 0.1%, and tetracaine 0.5%)|DRUG: EMLA plus infiltration as anesthetic for wound repair.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Observation on the Efficacy and Mechanism of SLIT With Dust Mite Allergen for PAR
Status: NOT_YET_RECRUITING
Conditions: Allergic Rhinitis
Interventions: DRUG: Dust mite drops (trade name: Changdi, Zhejiang Tawu Biotechnology Co. Ltd.).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Sirolimus for In-Stent Restenosis
Status: COMPLETED
Conditions: Coronary Restenosis
Interventions: DRUG: Sirolimus|DRUG: Sirolimus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy Combined With Adjuvant Chemoradiotherapy in Treating Patients With Resected Stage I or Stage II Adenocarcinoma (Cancer) of the Pancreas
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: GVAX pancreatic cancer vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Laser Destruction of Pilonidal Sinus Disease (SILAC) and Bascom II Procedure.
Status: ACTIVE_NOT_RECRUITING
Conditions: Pilonidal Disease
Interventions: PROCEDURE: Bascom II procedure|PROCEDURE: SiLaC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamics and Pharmacokinetics of Aspirin Inhalation Powder With Non-Enteric-Coated Chewable Aspirin
Status: COMPLETED
Conditions: Platelet Aggregation Inhibitors
Interventions: DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Motorized Continuous Cold Therapy Versus Standard Post-op Icing Protocol for Two Foot and Ankle Procedures
Status: TERMINATED
Conditions: Narcotic Consumption|Pain|Wound Healing|Patient Satisfaction
Interventions: DEVICE: Iceman® Cold Therapy unit (djOrtho)|OTHER: Ice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Fluoride Dose Response of a Modified In Situ Caries Model
Status: COMPLETED
Conditions: Caries
Interventions: DRUG: 0 ppm F (placebo, negative control)|DRUG: 250 ppm F as NaF (dose-response control)|DRUG: 500 ppm F as NaF (dose-response control)|DRUG: 1100 ppm F as NaF (positive control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Feasibility of Transvenous Phrenic Nerve Stimulation for Diaphragm Protection in Acute Respiratory Failure
Status: COMPLETED
Conditions: Acute Hypoxemic Respiratory Failure|Diaphragm Injury|Lung Injury
Interventions: DEVICE: Lungpacer AeroPace Protect System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: tDCS to Reduce Craving in Cocaine Addiction
Status: UNKNOWN
Conditions: Cocaine Use Disorder|Cocaine Dependence
Interventions: DEVICE: Soterix Medical mini-CT tDCS stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Comparison of Three Botulinum Neuromodulators for Management of Facial Synkinesis
Status: COMPLETED
Conditions: Facial Nerve Injuries|Facial Paresis Associated With Facial Nerve Dysfunction|Facial Asymmetry|Synkinesis
Interventions: DRUG: OnabotulinumtoxinA Injectable Product|DRUG: AbobotulinumtoxinA Injectable Product|DRUG: Incobotulinumtoxin A Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Multiple-Dose Escalation Study to Evaluate the Safety, Tolerability and Pharmacokinetic of HS-10383
Status: RECRUITING
Conditions: Cough
Interventions: DRUG: HS-10383|DRUG: HS-10383 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Conventional Care Versus Radioablation (Stereotactic Body Radiotherapy) for Extracranial Oligometastases
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer|Breast Cancer|Carcinoma, Non-Small-Cell Lung
Interventions: RADIATION: SBRT|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Melatonin on Cardiovascular and Muscle Mass and Function in Patients With Heart Failure
Status: UNKNOWN
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: Melatonin 10 mg|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Weekly Dosing of an Integrative Chemotherapy Combination to Treat Advanced Pancreatic Cancer
Status: UNKNOWN
Conditions: Adenocarincoma of Pancreas|Stage III Pancreatic Cancer|Stage IVA Pancreatic Cancer|Stage IVB Pancreatic Cancer
Interventions: DRUG: paclitaxel|DRUG: oxaliplatin|DRUG: leucovorin|DRUG: 5-fluorouracil|DRUG: glutathione|DRUG: calcium and magnesium|PROCEDURE: Chemotherapy|PROCEDURE: Chemoprotection|PROCEDURE: Complementary and alternative therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Pharmacokinetic Study of Econazole Nitrate Plus Benzydamine HCl Vaginal Pessary
Status: COMPLETED
Conditions: Healthy Women
Interventions: DRUG: Econazole nitrate 150 mg plus Benzydamine HCl 6 mg vaginal pessary|DRUG: Placebo plus Econazole nitrate 150 mg vaginal pessary|DRUG: Placebo plus Benzydamine HCl 6 mg vaginal pessary|DRUG: Placebo vaginal pessary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Omega-3 Fatty Acids on Fasting and Postprandial Triglycerides (TG) Response - a Pilot Study
Status: RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Omega- 3|DIETARY_SUPPLEMENT: HOSO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Automated Assessment of PVI Using a Novel EP Recording System
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation|Persistent Atrial Fibrillation
Interventions: DEVICE: CathVision Cube® system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of a Dog Training Therapy Program in UC Outpatient Youth Receiving Psychiatric Services
Status: NOT_YET_RECRUITING
Conditions: Emotion Regulation|Behavioral Disorder|Self Esteem
Interventions: BEHAVIORAL: Recovery & Care Canine-Assisted Therapy|OTHER: Canine Education & Bonding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Intermittent Hypoxic-hyperoxic Preconditioning for Patients Undergoing Cardiopulmonary Bypass.
Status: COMPLETED
Conditions: Valvular Heart Disease|Aortic Arch Aneurysm|Surgery
Interventions: DEVICE: ReOxy Cardio device, intermittent hypoxic-hyperoxic training ( IHHT)|DEVICE: ReOxy Cardio device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Long Term Cocoa Flavanol Intake on Blood Pressure and Platelet Function in Healthy Adults, Part 2
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Control Capsules|DIETARY_SUPPLEMENT: Mars Cocoa Extract Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Enhancing Purpose and Well-Being Through a Volunteering Experience Connecting Veterans With English Language Learners
Status: RECRUITING
Conditions: Depression|Anxiety|Post Traumatic Stress Disorder
Interventions: OTHER: Intervention (videoconferencing)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Trial Evaluating Toxicity of SBRT and LDRB in Localized Prostate Cancer.
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: Low-Dose Rate Brachytherapy to the prostate using Iodine-125 seed implant|RADIATION: Stereotactic Body Radiation Therapy to the prostate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate Treatment of Patients With Malignant Peripheral Nerve Sheath Tumors
Status: TERMINATED
Conditions: Malignant Peripheral Nerve Sheath Tumors
Interventions: DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Avatrombopag in Patients With End-stage Liver Disease and Thrombocytopenia
Status: UNKNOWN
Conditions: Liver Failure|Thrombocytopenia|Decompensated Cirrhosis
Interventions: DRUG: Avatrombopag|DRUG: Standard medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Stereotactic Body Radiation Therapy in Patients With Resectable Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: RADIATION: Preoperative Stereotactic body radiation therapy (SBRT), Pancreatic resection, Adjuvant Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Cutaneous Leishmaniasis With Meglumine Antimoniate Versus Meglumine Antimoniate and Allopurinol
Status: COMPLETED
Conditions: Leishmaniasis, Cutaneous
Interventions: DRUG: meglumine antimoniate, allopurinol|DRUG: meglumine antimoniate|DRUG: meglumine antimoniate, allopurinol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Accuracy and Safety of DBV1605 for the Diagnosis of Non-IgE Mediated Cow's Milk Allergy in Children
Status: UNKNOWN
Conditions: Cow's Milk Allergy
Interventions: COMBINATION_PRODUCT: DBV1605
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Use of Entresto Sacubitril/Valsartan for the Treatment of Peripheral Arterial Disease
Status: TERMINATED
Conditions: Peripheral Arterial Disease
Interventions: DRUG: Entresto|DRUG: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A 48 Week Study to Evaluate the Efficacy and Safety of Two (2) EYS606 Treatment Regimens in Subjects With Active Chronic Non-infectious Uveitis (CNIU)
Status: COMPLETED
Conditions: Non-infectious Uveitis
Interventions: COMBINATION_PRODUCT: EYS606
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Head and Neck Position on Performance of Ambu AuraGainTM in Children
Status: COMPLETED
Conditions: General Anesthesia
Interventions: OTHER: Neutral position|OTHER: Extension|OTHER: Flexion|OTHER: Rotation|DEVICE: Ambu AuraGain TM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Use of Knotless Suture for Closure of Total Hip and Knee Arthroplasties
Status: COMPLETED
Conditions: Knee Osteoarthritis|Hip Osteoarthritis
Interventions: DEVICE: Knotless suture for wound closure|DEVICE: Layered traditional wound closure (monocryl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intramyometrial Injection of Terlipressin Versus Carbitocin on Hemoglobin and Blood Loss During Open Myomectomy Operations Using Haemostatic Tourniquets:
Status: COMPLETED
Conditions: Myoma
Interventions: DRUG: Terlipressin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Initializing the Control-IQ Artificial Pancreas System Using Total Daily Insulin
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: Hybrid Closed Loop (HCL)|DEVICE: Control-IQ with MyTDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Trial of HRF2105 Patch in Relieving Pain of Osteoarthritis
Status: NOT_YET_RECRUITING
Conditions: Analgesia and Anti-inflammatory of Osteoarthritis
Interventions: DRUG: HRF2105 patch|DRUG: Loxoprofen patch|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bi-PAP vs Sham Bi-PAP on Pulmonary Function in Morbidly Obese Patients After Bariatric Surgery
Status: COMPLETED
Conditions: Atelectasis|Pulmonary Infection|Chronic Obstructive Pulmonary Disease (COPD)|Pulmonary Disease|Hypoxemic Respiratory Failure|Hypoxemia|Morbid Obesity
Interventions: DEVICE: Bi-PAP|DEVICE: Sham Bi-PAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II/III Study of the AVX/COVID-12 Vaccine Against COVID-19 Applied as a Booster.
Status: COMPLETED
Conditions: SARS-CoV-2 Infection
Interventions: BIOLOGICAL: AVX-COVID/12|BIOLOGICAL: ChAdOx-1-S[recombinant]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Heat Shock Response is Blunted in Elderly Diabetic People But Recovered by Strength Training
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Aging
Interventions: OTHER: Strength training|OTHER: No Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: "SALT Trial" Study of Ascending Levels of Tolvaptan in Hyponatremia
Status: COMPLETED
Conditions: Hyponatremias|Water Intoxication|Inappropriate ADH Syndrome|Water-Electrolyte Imbalances
Interventions: DRUG: tolvaptan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Investigational Drug HBI-8000 + Nivolumab vs. Placebo + Nivolumab in Patients With Advanced Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Unresectable or Metastatic Melanoma|Progressive Brain Metastasis
Interventions: DRUG: HBI-8000 in combination with nivolumab|DRUG: Placebo in combination with nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Axumin PETMRI Imaging Following Focal Cryo-ablation (FCA)
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DEVICE: Standard of Care MRI|OTHER: Fluciclovine PET scan added to MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Role of Oxidative Stress in Ovarian Tissue After CO2-pneumoperitoneum Application-induced I/R
Status: COMPLETED
Conditions: Oophorectomy|Oxidative Stress|Ischemia Reperfusion Injury
Interventions: PROCEDURE: laparoscopic salpingo-oophorectomy|PROCEDURE: Laparoscopic bilateral salpingo-oophorectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Motivational Coaching to Enhance Mental Health Engagement in Rural Veterans
Status: COMPLETED
Conditions: Mental Health|Rural Health|Veterans Health
Interventions: BEHAVIORAL: Motivational Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of AUP12602-C as New Topical Treatment for DFUs (DIAMEND STUDY)
Status: RECRUITING
Conditions: Diabetic Foot Ulcer
Interventions: BIOLOGICAL: AUP1602-C|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Electrostimulation in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: Electrostimulation|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Gathering Online for Dialogue and Discussion to Enhance Social Support
Status: NOT_YET_RECRUITING
Conditions: Alcohol Misuse|HIV|Sexually Transmitted Infections|Pre-exposure Prophylaxis
Interventions: BEHAVIORAL: mHealth-Women's CoOp|BEHAVIORAL: Virtual Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial Evaluating Pitolisant (BF2.649) in Alcohol Use Disorder Treatment
Status: WITHDRAWN
Conditions: Alcohol Abuse, Nervous System
Interventions: DRUG: Pitolisant (BF2.649)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Infusion of 5-Azacytidine (5-AZA) Into the Fourth Ventricle in Children With Recurrent Posterior Fossa Ependymoma
Status: COMPLETED
Conditions: Brain Tumor Recurrent
Interventions: DRUG: 5-Azacytidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of GW685698X For The Treatment Of Perennial Allergic Rhinitis In Pediatrics
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial
Interventions: DRUG: GW685698X aqueous nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Real-time Ultrasound Imaging as Feedback for Deep Cervical Extensors Activation
Status: UNKNOWN
Conditions: Neck Disorder
Interventions: OTHER: DCE without RUSI feedback|OTHER: DCE + RUSI feedback about performance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Cervical Transforaminal Epidural Steroid Injection
Status: COMPLETED
Conditions: Cervical Radiculopathy|Cervical Spondylosis|Disk, Herniated
Interventions: DRUG: Cervical Transforaminal Epidural Injection with dexamethasone sodium phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety Study of Monoclonal Antibodies to Reduce the Vaginal Transmission of HSV and HIV
Status: COMPLETED
Conditions: HIV|Herpes Simplex Infections
Interventions: DRUG: MB66|DRUG: Placebo Film
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study Confirming A Human Challenge Model and Investigating The Safety Of VLA1701
Status: COMPLETED
Conditions: Enterotoxigenic Escherichia Coli Infection|Diarrhea
Interventions: BIOLOGICAL: VLA1701|BIOLOGICAL: Placebo|OTHER: Challenge Strain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Non-interventional Study for Women With HR-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer to Evaluate the Real-world Effectiveness of Treatment Algorithms Beginning With Ribociclib + AI/FUL, or With Endocrine Therapy or Chemotherapy as First Line Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: First-line Ribociclib + endocrine therapy|DRUG: First-line endocrine therapy|DRUG: First-line chemtherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Efficacy and Safety Study of Palonosetron in Preventing Chemotherapy-Induced Nausea and Vomiting (CINV) in the Chinese Cancer Patients
Status: COMPLETED
Conditions: Chemotherapy-Induced Nausea and Vomiting
Interventions: DRUG: palonosetron|DRUG: Granisetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study in Adult Ph-positive ALL
Status: NOT_YET_RECRUITING
Conditions: Acute Lymphoblastic Leukemia, Adult
Interventions: DRUG: Ponatinib|DRUG: Blinatumomab|DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Dextrose on Knee Osteoarthritis
Status: UNKNOWN
Conditions: Physical Activity|Functional Disturbance
Interventions: DRUG: dextrose|DEVICE: hyaluronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Memantine Hydrochloride in Enhancing the Cognitive Abilities of Young Adults With Down Syndrome
Status: COMPLETED
Conditions: Down Syndrome
Interventions: DRUG: Memantine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Trial to Assess the Comparative Bioavailability of TV-44749 to Oral Olanzapine in Participants With Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: TV-44749|DRUG: Oral olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of KLH-2109 in Uterine Fibroids Patient With Menorrhagia
Status: ACTIVE_NOT_RECRUITING
Conditions: Uterine Fibroids (MeSH Heading: Leiomyoma)
Interventions: DRUG: KLH-2109|DRUG: Leuprorelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Efficacy and Safety of Abatacept in Combination With Standard Therapy Compared to Standard Therapy Alone in Improving Disease Activity in Adults With Active Idiopathic Inflammatory Myopathy
Status: COMPLETED
Conditions: Polymyositis|Dermatomyositis|Autoimmune Necrotizing Myopathy|Overlap Myositis|Juvenile Myositis Above the Age of 18
Interventions: DRUG: Abatacept subcutaneous|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Escalation Study of ALXN1210 IV in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)
Status: COMPLETED
Conditions: PNH
Interventions: BIOLOGICAL: ALXN1210
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiologic Scoring of Patients With Chronic Sinusitis and Nasal Polyps
Status: UNKNOWN
Conditions: Chronic Sinusitis
Interventions: DRUG: Hypertonic saline|DRUG: Fluticasone Nasal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: XELOX+Bevacizumab and XELIRI + Bevacizumab Alternative Regimen as First-line Treatment for Advanced Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Neoplasms|Chemotherapy
Interventions: DRUG: XELIRI + bevacizumab|DRUG: XELOX + bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Proof-of-mechanism Study of Multiple, Oral Doses of Fevipiprant (QAW039) in COPD Patients With Eosinophilia
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: QAW039|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Montelukast in Pediatric Patients Aged 6 to 24 Months With Asthma--Safety Study (0476-176)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: montelukast sodium|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Recombinant Vaccinia Virus in Combination With Cemiplimab for Renal Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: BIOLOGICAL: Pexastimogene Devacirepvec (Pexa-Vec)|BIOLOGICAL: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microcirculatory and Tissue and Cerebral Oxygenation in Preeclampsia and Normal Pregnancy: An Observation Study
Status: WITHDRAWN
Conditions: Pregnancy|Eclampsia
Interventions: DEVICE: CytoCam|DEVICE: NIRS Artinis PortaLite with OxySoft softwear
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of AL-15469A 0.5% / AL-6515 0.3% Ophthalmic Suspension for Treatment of Bacterial Conjunctivitis
Status: WITHDRAWN
Conditions: Bacterial Conjunctivitis
Interventions: DRUG: AL-15469A 0.5% and AL-6515 0.3% Ophthalmic Suspension|DRUG: AL-15469A 0.5%|DRUG: AL-6515 0.3%|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Taitacept in Treatment of Refractory or Recurrent Anti-NMDAR/Anti-LGI1 Encephalitis
Status: RECRUITING
Conditions: Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Interventions: DRUG: Taitacept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Primary Care Clinical Excellence Incentive Study
Status: COMPLETED
Conditions: Behavioral Economics|Primary Health Care|Health Maintenance|Diabetes|Colorectal Cancer Screening|Cervical Cancer Screening|Chlamydia Screening|HPV Screening
Interventions: BEHAVIORAL: Standard communication email|BEHAVIORAL: Social comparison Intervention|BEHAVIORAL: Leadership Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Diagnostic Efficacy of Glutamine Synthetaseand BCLAF1in Early Diagosis of Hepatocellular Carcinoma in Cirrhotic Patients
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: OTHER: measure of Glutamine synthetase and BCLFAF1
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Weizmania Coagulans BC99 Intervention on Gut Microbiota and Metabolic Markers in Overweight Adults
Status: NOT_YET_RECRUITING
Conditions: Overweight
Interventions: DIETARY_SUPPLEMENT: Weizmania Coagulans BC99
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Palbociclib in Combination With Lenalidomide and Dexamethasone for Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Palbociclib|DRUG: Dexamethasone|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bendamustine Hydrochloride and Rituximab With or Without Bortezomib Followed by Rituximab With or Without Lenalidomide in Treating Patients With High-Risk Stage II, Stage III, or Stage IV Follicular Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: Bendamustin|DRUG: bortezomib|DRUG: lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of a Single Oral Dose of Maribavir Administered in Healthy Japanese Participants Compared With Matched, Healthy, Non-Hispanic, Caucasian Participants and to Assess Dose-Proportionality of 3 Doses of Maribavir in Japanese Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Maribavir (400 mg)|DRUG: Maribavir (200 mg)|DRUG: Maribavir (800 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiology of Long COVID-19 and the Impact of Cardiopulmonary Rehabilitation on Quality-of-Life and Functional Capacity
Status: RECRUITING
Conditions: Post-acute Sequelae of SARS-CoV-2 Infection
Interventions: BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epiceram Versus Elidel for Treatment of Mild to Moderate Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Elidel(R) (pimecrolimus 1%)|DEVICE: EpiCeram(R) -ceramide based barrier repair cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Plantar Callosities and the Validity of Body Composition Assessment by Bio-impedance in Severely Obese Persons
Status: COMPLETED
Conditions: Obesity, Morbid
Interventions: DEVICE: Bioelectric impedance|DEVICE: Air displacement plethysmography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Adding PIFP Block to SAP Block on Postoparative Pain Management in Patient Planned for Breast Surgery
Status: RECRUITING
Conditions: Pain Management
Interventions: PROCEDURE: serratus anterior plane block and pectointercostal plane block in breast surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Paclitaxel, Cisplatin,5-FU vs. Radiotherapy Plus Paclitaxel, Cisplatin as Preoperative Therapy for Locally Advanced ESC
Status: UNKNOWN
Conditions: Esophageal Cancer Stage IIB|Esophageal Cancer Stage III
Interventions: COMBINATION_PRODUCT: Paclitaxel, Cisplatin Plus 5-FU (TCF)|RADIATION: radiochemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phytotherapy Agent in Third Molar Surgery
Status: COMPLETED
Conditions: Oral Soft Tissue Conditions
Interventions: DRUG: Lenidase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between the Efficacy of CIMT and NDT Along With Conventional Physiotherapy Treatment on Upper Extremity Rehabilitation Among Patients of Stroke
Status: NOT_YET_RECRUITING
Conditions: Strokes Thrombotic
Interventions: OTHER: Constraint-induced movement therapy|OTHER: Neurodevelopmental Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Stevioside in Postpandrial Glucose in Healthy Adults
Status: WITHDRAWN
Conditions: Hyperglycemia|Hypertension
Interventions: DRUG: Purified extract of Rebaudina Stevia-Stevioside|DRUG: Sodium saccharin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid During Excisional Burn Surgery
Status: RECRUITING
Conditions: Burns|Blood Loss, Surgical|Blood Loss|Tranexamic Acid|Burn Excisional Surgery
Interventions: DRUG: Tranexamic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First in Human Study With NG-641, a Tumour Selective Transgene Expressing Adenoviral Vector
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Cancer|Epithelial Tumor
Interventions: BIOLOGICAL: NG-641
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiological Evaluation of the Penis Before and After a Botox Injection
Status: RECRUITING
Conditions: Erectile Dysfunction
Interventions: PROCEDURE: Injection of Botulinum neurotoxin (BoNT)|DIAGNOSTIC_TEST: Penile duplex and shear wave elastosonography (SWE).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Acalabrutinib Suspension to Evaluate Relative Bioavailability and Proton-pump Inhibitor Effect in Healthy Volunteers
Status: COMPLETED
Conditions: Pharmacokinetics|Bioavailability
Interventions: DRUG: Acalabrutinib Treatment A|DRUG: Acalabrutinib Treatment B|DRUG: Acalabrutinib Treatment C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Study of TLL018, With Food Effect, in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: TLL018 tablet, placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Ultrasound-guided Transgluteal and Finger-guided Transvaginal Pudendal Nerve Block Techniques
Status: COMPLETED
Conditions: Neuralgia|Pudendal Nerve|Pudendal Nerve Block
Interventions: PROCEDURE: Ultrasound-guided transgluteal pudendal nerve injection (TG-PNI)|PROCEDURE: Finger-guided transvaginal pudendal nerve injection (TV-PNI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety/Tolerance Phase, Ascending Single Dose Study to Evaluate the Safety and Tolerability of G3P-01, a Food-Grade Pectic Product, in Healthy Volunteers
Status: COMPLETED
Conditions: Gastrointestinal Discomfort|Performance Status
Interventions: DIETARY_SUPPLEMENT: G3P-01
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept Study of OC000459 in Eosinophilic Esophagitis
Status: COMPLETED
Conditions: Eosinophilic Esophagitis
Interventions: DRUG: OC000459|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Immunogenicity and Safety of EV71 Vaccine in Pediatric Subjects
Status: COMPLETED
Conditions: Enterovirus Infections
Interventions: BIOLOGICAL: EV71 vaccine ([0.5 μg total protein + adjuvant 150 μg AI(OH)3] per dose)|BIOLOGICAL: EV71 vaccine ([1 μg total protein + adjuvant 150 μg AI(OH)3] per dose)|BIOLOGICAL: EV71 vaccine ([1 μg total protein ] per dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION