pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of MB07811 in Subjects With Hypercholesterolemia
Status: WITHDRAWN
Conditions: Hypercholesterolemia
Interventions: DRUG: MB07811|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment and Assessment of Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: Radial Shockwave Therapy|OTHER: Placebo Comparator: Group 2 - Placebo Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Genetically-informed Behavioral and Cognitive Interventions for the Management of Tinnitus
Status: UNKNOWN
Conditions: Tinnitus
Interventions: BEHAVIORAL: Cognitive Behavioral Treatment (CBT) and Tinnitus Retraining Therapy (TRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Small-sample, Real-world Study of Sintilimab Plus Bevacizumab/Cetuximab Plus XELOX Regimen for Conversion Therapy in Patients With Advanced Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: Sintilimab ，bevcizumab/cetuximab，XELOX
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Meals on Wheels, the Effect of a Home Food-delivery Service for Cancer Patients
Status: COMPLETED
Conditions: Lung Cancer|Ambulant|Malnourished
Interventions: DIETARY_SUPPLEMENT: Home food-delivery service
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomized Evaluation of a Positioning Pillow for Lumbar Puncture in Paediatric Hematology-Oncology
Status: COMPLETED
Conditions: Spinal Puncture
Interventions: DEVICE: pillow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Congenital Cytomegalovirus: Efficacy of Antiviral Treatment in a Randomized Controlled Trial
Status: TERMINATED
Conditions: Congenital Cytomegalovirus Infection|Sensorineural Hearing Loss
Interventions: DRUG: Valganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Safety Study of LAmbre Left Atrial Appendage Occluder
Status: COMPLETED
Conditions: Atrial Fibrillation|Stroke
Interventions: DEVICE: LAmbre Left Atrial Appendage(LAA) Occluder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Clinical Value in the Use of the Fascia Lata and Temporal Muscle Fascia in the Reconstruction of the Dura in the Sellar Region
Status: RECRUITING
Conditions: Skull Defect|Transplant Complication|Quality of Life
Interventions: PROCEDURE: Fascia lata|PROCEDURE: Temporal fascia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mobile Screening for Major Depressive Disorder in Adults From an Ethnically and Socioeconomically Diverse Population.
Status: NOT_YET_RECRUITING
Conditions: Major Depressive Disorder
Interventions: OTHER: Patient health questionnaire-9 via the Your Research application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Low-Intensity Chemotherapy and Blinatumomab in Treating Patients With Philadelphia Chromosome Negative Relapsed or Refractory Acute Lymphoblastic Leukemia
Status: TERMINATED
Conditions: Philadelphia Chromosome Negative|Recurrent B Acute Lymphoblastic Leukemia|Refractory B Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: Blinatumomab|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Dexamethasone|BIOLOGICAL: Filgrastim|OTHER: Laboratory Biomarker Analysis|DRUG: Leucovorin Calcium|DRUG: Mercaptopurine|DRUG: Methotrexate|BIOLOGICAL: Pegfilgrastim|BIOLOGICAL: Rituximab|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Extended Release Torsemide in Patients With Congestive Heart Failure and Overactive Bladder
Status: RECRUITING
Conditions: Heart Failure|Overactive Bladder|Incontinence
Interventions: DRUG: Extended release torsemide|DRUG: Immediate release torsemide|DRUG: Extended release torsemide placebo|DRUG: Immediate release torsemide placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fufang E'Jiao Jiang Intervening Cancer-related Fatigue
Status: UNKNOWN
Conditions: Cancer-related Fatigue
Interventions: DRUG: Fufang E'Jiao Jiang|DRUG: placebo containing low-dose fufang E'Jiao Jiang
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Sterilization Technique on Incidence of Urinary Tract Infection After Cystoscopy
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: PROCEDURE: clean patient preparation for cystoscopy|PROCEDURE: sterile patient preparation for cystoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Pharmacokinetics of Topical Timolol in Infants With Infantile Hemangioma (IH)
Status: COMPLETED
Conditions: Infantile Hemangioma
Interventions: DRUG: 0.25% Timolol Maleate Gel Forming Solution|DRUG: 0.5% Timolol Maleate Gel Forming Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of Two Commercial, Daily Disposable Contact Lenses
Status: COMPLETED
Conditions: Refractive Errors|Ametropia|Myopia
Interventions: DEVICE: Delefilcon A contact lenses|DEVICE: Kalifilcon A contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized Extended Interval Dosing of Natalizumab in Relapsing Remitting Multiple Sclerosis
Status: ENROLLING_BY_INVITATION
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: Personalized extended interval dosing of natalizumab|DRUG: Standard interval dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Properties of Two Dosages Nevirapine Extended Release (XR) Formulations Compared to VIRAMUNE® Tablet as Well as to Nevirapine XR Tablet in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Nevirapine XR low dose|DRUG: Nevirapine XR medium dose|DRUG: Nevirapine XR high dose|DRUG: Nevirapine (VIRAMUNE®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Bone Marrow Mononuclear Cells in the Combined Treatment of Coronary Heart Disease
Status: COMPLETED
Conditions: Ischemic Heart Disease|Bone Marrow Cells|Coronary Artery Bypass Grafting (CABG)|Heart Failure, Diastolic
Interventions: PROCEDURE: Group 1|PROCEDURE: Group 0|PROCEDURE: Group 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Contact Lenses on Tear Osmolarity in a Controlled Low Humidity Chamber
Status: COMPLETED
Conditions: Myopia|Dry Eye
Interventions: DEVICE: lotrafilcon A contact lenses|DEVICE: comfilcon A contact lenses|OTHER: Glasses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Effect of Electroacupuncture on Postoperative Analgesia After Cesarean Sectionanalgesia After Cesarean Section
Status: COMPLETED
Conditions: Cesarean Section
Interventions: OTHER: PCIA +Acupuncture group:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Carboprost (Hemabate) for Fibroid Resection
Status: RECRUITING
Conditions: Fibroid Uterus|Gynecologic Disease|Leiomyoma, Uterine
Interventions: DRUG: Carboprost Tromethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of ACE Inhibitors, MRAs and ACE Inhibitor/ MRA Combination
Status: UNKNOWN
Conditions: Diabetic Nephropathy Type 2|Microalbuminuria Due to Type 2 Diabetes Mellitus
Interventions: DRUG: Tritace (Ramipril 10 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: IVUS Controlled Stenting
Status: UNKNOWN
Conditions: Coronary Angioplasty and Stenting|Single de Novo Coronary Artery Stenoses
Interventions: DEVICE: Oversized stent deployed at low pressure (Multi-Link Bare Metal Stent or Xience Prime Evenolimus Eluting Stent)|DEVICE: Stent deployed at high pressure (Multi-Link Bare Metal Stent or Xience Prime Evenolimus Eluting Stent)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pyrotinib Combined With Trastuzumab and AI in the First-line Treatment of HER2 Positive/ HR Positive MBC
Status: UNKNOWN
Conditions: Breast Cancer Female|HER2-positive Breast Cancer|Hormone Receptor Positive Malignant Neoplasm of Breast|Metastatic Breast Cancer|Breast Diseases|Hormone Receptor Positive Tumor
Interventions: DRUG: Pyrotinib|DRUG: Trastuzumab|DRUG: Aromatase inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transplantation After Complete Response In Patients With T-cell Lymphoma
Status: RECRUITING
Conditions: Peripheral T Cell Lymphoma
Interventions: PROCEDURE: Chemotherapy + follow up|PROCEDURE: Chemotherapy + ASCT + follow up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy of All-Oral Anti-Viral Therapy for Symptomatic Hepatitis C Virus Infection-Related Cryoglobulinemia
Status: COMPLETED
Conditions: Hepatitis C|Cryoglobulinemia
Interventions: DRUG: Harvoni|DRUG: Epclusa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topiramate to Aid Smoking Cessation in Alcohol Dependent Men
Status: COMPLETED
Conditions: Nicotine Dependence|Alcohol Dependence
Interventions: DRUG: Topiramate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotic Strain Lactobacillus Paracasei PS23 on Brain Fog in People With Long COVID
Status: NOT_YET_RECRUITING
Conditions: Long COVID|Brain Fog|Cognitive Change
Interventions: DIETARY_SUPPLEMENT: Lactobacillus paracasei PS23|DIETARY_SUPPLEMENT: microcrystalline cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Decitabine in Relapsed or Refractory T-lymphoblastic Lymphoma
Status: UNKNOWN
Conditions: T-lymphoblastic Lymphoma
Interventions: COMBINATION_PRODUCT: CODOX-M/IVAC|DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Investigating the Dose Linearity and Safety of BC Combo THDB0207 in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Euglycemic clamp with BC Combo THDB0207|DRUG: Euglycemic clamp with Humalog® Mix25
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Prophylactic Versus Empirical Vancomycin for the Prevention of Streptococcal Sepsis After Hematopoietic Cell Transplantation
Status: COMPLETED
Conditions: Streptococcal Sepsis|Hematologic Malignancies
Interventions: DRUG: Empirical Vancomycin|DRUG: Prophylactic Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial of Benefit Finding in Caregivers: The Building Resources in Caregivers (BRiC) Study
Status: COMPLETED
Conditions: Quality of Life|Psychological Distress
Interventions: BEHAVIORAL: Benefit-finding Writing Activity|BEHAVIORAL: Neutral Writing Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Follow-up Study With Clinical Vitamin D Supplementation Trial on Patients With Depression (DepFuD)
Status: RECRUITING
Conditions: Depression|Depressive Disorder
Interventions: DIETARY_SUPPLEMENT: Vitamin D 10 micrograms|DIETARY_SUPPLEMENT: Vitamin D 100 micrograms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility of ActivSightTM in Human
Status: ENROLLING_BY_INVITATION
Conditions: Acute Cholecystitis|Colorectal Cancer|Diverticulitis, Colonic|Obesity, Morbid|Inflammatory Bowel Diseases
Interventions: DEVICE: ActivSight
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Signature Personalised Patient Care System With the Vanguard Knee System Study
Status: TERMINATED
Conditions: Arthroplasty, Replacement, Knee
Interventions: PROCEDURE: Vanguard Knee System with Signature Knee Guide|PROCEDURE: Vanguard Knee System with conventional Instruments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of HydroLenz for Vitrectomy-Induced Lens Opacities
Status: NOT_YET_RECRUITING
Conditions: Pars Plana Vitrectomy
Interventions: DRUG: HydroLenz Injection|OTHER: No HydroLenz Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Topical Microporous Polysaccharide Hemospheres Versus Electrocautery for Control of Pediatric Post-Tonsillectomy Bleeding
Status: WITHDRAWN
Conditions: Obstructive Sleep Disorder|Obstructive Sleep Apnea|Tonsillar Hypertrophy
Interventions: DEVICE: Micropolysaccharide Hemospheres (Arista)|DEVICE: Electrocautery (Monopolar suction cautery)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CDK 4/6 Inhibitor, Ribociclib, With Adjuvant Endocrine Therapy for ER-positive Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Ribociclib|OTHER: Endocrine therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-Center, Exploratory Study to Analyze the Dynamics of Skin Microflora Following Exposure to Surfactants
Status: COMPLETED
Conditions: Dermatitis
Interventions: OTHER: PEG-40 Hydrogenated Castor Oil (Tagat CH40, Evonik) 1.5%|OTHER: Lauryl glucoside (Plantacare® 1200UP, BASF) 1.5%|OTHER: Sorbitan palmitate (SPANTM 40 (powder), Croda) 1.5%|OTHER: Silwet* DA-63 (Momentive) 1.5%|OTHER: Sodium lauryl sulfate (Sigma Aldrich) 1.0%|OTHER: Water (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Chlorhexidine Gluconate Versus Povidone-Iodine as Vaginal Preparation Antiseptics Prior to Cesarean Delivery
Status: COMPLETED
Conditions: Infection, Bacterial
Interventions: DRUG: Chlorhexidine Gluconate|DRUG: Povidone-Iodine Scrub and Paint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Soft Tissue Treatment vs Mechanisms Explanation to Treat Delayed Onset Muscles Soreness Among Sport Climbers
Status: COMPLETED
Conditions: Central Nervous System Sensitization|Peripheral Nervous System Disorders|Muscle Soreness|Muscle Strength
Interventions: OTHER: Soft tissue treatment|OTHER: Mechaninsms explanation|OTHER: Control Group|OTHER: Neurodynamic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Acute Cholecystitis With ETGBD
Status: NOT_YET_RECRUITING
Conditions: Biliary Obstruction|Acute Cholecystitis
Interventions: DEVICE: Endoscopic transpapillary gallbladder drainage (ETGBD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence Study of CJ-30059
Status: UNKNOWN
Conditions: Healthy Volunteers
Interventions: DRUG: Candesartan cilexetil 16 mg and Amlodipine besylate 10mg (Reference)|DRUG: CJ-30059 (Test)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Helping Those With Mental Illness Quit Smoking
Status: COMPLETED
Conditions: Smoking|Nicotine Dependence|Mental Disorders
Interventions: BEHAVIORAL: Cognitive / Motivational Individual Sessions|BEHAVIORAL: Attention Control Individual Sessions|DRUG: Nicotine Patch|BEHAVIORAL: Group Curriculum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Dexmedetomidine For The Quaity Of Emergence From General Anesthesia
Status: COMPLETED
Conditions: Anesthesia Recovery|Anesthesia Emergence|Shivering|Postoperative Recovery
Interventions: DRUG: dexmedetomidine 0.25 µg/kg IV|DRUG: dexmedetomidine 0.5 µg/kg IV|DRUG: dexmedetomidine 1 µg/kg IV|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Immune Response in Patients Who Have Undergone Vaccine Therapy for Stage III or Stage IV Breast Cancer That Overexpresses HER2
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: HER-2/neu intracellular domain protein|OTHER: flow cytometry|OTHER: immunohistochemistry staining method|PROCEDURE: biopsy|OTHER: Sterile water placement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Uproleselan With Pre-Transplant Conditioning in Hematopoietic Stem Cell Transplantation for AML
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|Pediatric Cancer
Interventions: DRUG: Uproleselan|DRUG: Fludarabine|DRUG: Clofarabine|DRUG: Busulfan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Management Strategy of PDA for VLBW Preterm Infants
Status: TERMINATED
Conditions: Ductus Arteriosus, Patent|Preterm Infants
Interventions: DRUG: Indomethacin and Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ultrasound Guided ESP Vs Video-assisted PVB Catheter Placement in Minimally Invasive Thoracic Surgery
Status: COMPLETED
Conditions: Regional Anesthesia Morbidity|Pain, Postoperative|Pain, Chronic
Interventions: PROCEDURE: Anaesthesiologist-administered ultrasound guided Erector Spinae block with catheter insertion|PROCEDURE: Surgeon-administered video-assisted Paravertebral block with catheter insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Effectiveness of SJP-0035 for the Treatment of Patients With Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: SJP-0035 0.001%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Examining Low Sulfur Diet as Treatment for Persistent Symptoms in Quiescent Crohn's Disease
Status: RECRUITING
Conditions: Crohn's Disease in Remission
Interventions: OTHER: Low Sulfur Diet|OTHER: Usual Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HBV Vaccine in Renal Failure Patients
Status: COMPLETED
Conditions: Renal Failure
Interventions: BIOLOGICAL: Intradermal HBVv with imiquimod|BIOLOGICAL: Intradermal HBVv with aqueous cream|BIOLOGICAL: Intramuscular HBVv with aqueous cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Mucosal Sparing Adjuvant Radiotherapy After Surgical Exploration in HPV+ Head and Neck Cancer of Unknown Primaries
Status: COMPLETED
Conditions: Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Head and Neck Carcinoma of Unknown Primary|Pathologic Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
Interventions: OTHER: Medical Chart Review|OTHER: Patient Observation|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Asthma and Nasal Steroids
Status: COMPLETED
Conditions: Asthma|Rhinitis|Sinusitis
Interventions: DRUG: Mometasone Furoate monohydrate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Phase 2a Study of IW-9179 to Treat Functional Dyspepsia
Status: TERMINATED
Conditions: Dyspepsia|Functional Gastrointestinal Disorders
Interventions: DRUG: IW-9179|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GPi+NBM DBS in Parkinson's Disease With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Parkinson Disease|Memory Disorders
Interventions: DEVICE: NBM stimulation using the Vercise device (Boston Scientific, Marlborough, Massachusetts, US)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Satisfaction With Evie
Status: COMPLETED
Conditions: Infertility
Interventions: DEVICE: Evie Slow-release Insemination Device|OTHER: Traditional Intrauterine Insemination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Inferior Oblique Myectomy Versus Anterior and Nasal Transposition of Its Tendon for Treatment of Superior Oblique Muscle Palsy
Status: COMPLETED
Conditions: Superior Oblique Palsy
Interventions: PROCEDURE: inferior oblique weakening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Hemiparetic Arm Robotic Mobilization With Non Invasive Electrical Stimulation
Status: COMPLETED
Conditions: Stroke|Paresis|Upper Extremity Paralysis
Interventions: DEVICE: Real dual tDCS + Robotic Arm Therapy|DEVICE: SHAM tDCS + Robotic Arm Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety, Tolerability, and Antiviral Activity of Chlorcyclizine HCl in Patients With Chronic Hepatitis C
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Chlorcyclizine HCl|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Eritoran (E5564) Administered IV Over 14 Days Prior to and During Bone Marrow Engraftment in BMT Patients Who Have Received Myeloablative Conditioning Treatment and Are Receiving Bone Marrow or Stem Cells From Matched Related Donors
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: E5564
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Human Amniotic Epithelial Cells Treatment for Ovarian Insufficiency
Status: UNKNOWN
Conditions: Premature Ovarian Failure
Interventions: BIOLOGICAL: hAECs|PROCEDURE: Minimally invasive implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patritumab With Cetuximab and a Platinum Containing Therapy for Patients With Head and Neck Cancer
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Patritumab|DRUG: Cetuximab|DRUG: Cisplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Kegel Exercises Book to Improve Treatment in Stress Urinary Incontinence Women
Status: UNKNOWN
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: Kegel Exercises guidebook
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment of a New Catheter Surface Coating With Antimicrobial Properties
Status: COMPLETED
Conditions: Renal Insufficiency
Interventions: DEVICE: GamCath® central venous catheter|DEVICE: GamCath Dolphin® Protect central venous catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Ovarian Epithelial Cancer
Status: TERMINATED
Conditions: Ovarian Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: paclitaxel|DRUG: topotecan hydrochloride|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on the Application of a Specimen Retrieving Bag to Reduce the Polyp Fragmentation Rate
Status: COMPLETED
Conditions: Colonic Polyp
Interventions: DEVICE: Specimen retrieving bag|BEHAVIORAL: Sucking polyps to the instrument channel port
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trials of Adjuvant Androgen Deprivation in Localized Prostate Cancer
Status: COMPLETED
Conditions: Prostate Adenocarcinoma
Interventions: DRUG: Short term androgen deprivation|DRUG: Long term androgen deprivation|RADIATION: Short term androgen deprivation|RADIATION: Long term androgen deprivation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Staple Line Reinforcement Procedures on Postoperative Nausea and Vomiting in Sleeve Gastrectomy
Status: RECRUITING
Conditions: Bariatric Surgical Procedures|Nausea, Postoperative|Vomiting, Postoperative
Interventions: OTHER: Postoperative Nausea and Vomiting scala|OTHER: Quality of life
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Exploratory Study Using Positron Emission Tomography With TS-121 and [11C]TASP0410699 in Healthy Adult Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: TS-121|DRUG: [11C]TASP0410699|RADIATION: Positron Emission Tomography (PET)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Feasibility Study for GORE® TAG® Thoracic Branch Endoprosthesis to Treat Proximal Descending Thoracic Aortic Aneurysms
Status: COMPLETED
Conditions: Aortic Aneurysm, Thoracic
Interventions: DEVICE: GORE® TAG® Thoracic Branch Endoprosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study to Evaluate TRS01 Eye Drops in Participants With Active Non-infectious Anterior Uveitis
Status: COMPLETED
Conditions: Non-infectious Anterior Uveitis
Interventions: DRUG: TRS01 eye drops|DRUG: TRS01 eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IV Ibuprofen for the Prevention of Post-ERCP Pancreatitis
Status: TERMINATED
Conditions: Post-ERCP Acute Pancreatitis
Interventions: DRUG: Ibuprofen|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Imatinib Mesylate in Patients With Various Types of Malignancies Involving Activated Tyrosine Kinase Enzymes
Status: COMPLETED
Conditions: Hypereosinophilic Syndrome|Systemic Mastocytosis|Chronic Myelomonocytic Leukemia|Dermatofibrosarcoma
Interventions: DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Prediction of Extent and Risk Profile of Coronary Atherosclerosis and Their Changes During Lipid-lowering Therapy Based on Non-invasive Techniques
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Neuroactive Steroids in Stress, Drug Craving and Drug Use in Cocaine Use Disorders
Status: COMPLETED
Conditions: Cocaine-Related Disorders
Interventions: DRUG: Pregnenolone (PREG)|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study in Participants With Moderate to Severe Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: 80 mg Ixekizumab Dosing Regimens 1, 2, and 3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Do More, B'More, Live Fit
Status: COMPLETED
Conditions: Cystic Fibrosis|Physical Activity
Interventions: BEHAVIORAL: Personalized-Coaching Interventions|BEHAVIORAL: Motivational Messages|BEHAVIORAL: Online Exercise Tutorials|BEHAVIORAL: Social Support and Peer Challenges
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Xeltis Coronary Artery Bypass Graft (XABG) First in Human (FIH)
Status: ENROLLING_BY_INVITATION
Conditions: Multi Vessel Coronary Artery Disease
Interventions: DEVICE: CABG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concentrations of Pro-inflammatory and Anti-inflammatory Cytokines and Metallopeptidases in the Serum During the Treatment of Pain Caused by Bulging of the Intervertebral Disc in the Lumbar Spine
Status: RECRUITING
Conditions: Intervertebral Disc Herniation|Back Pain|Analgesic Nephropathy|Inflammatory Response
Interventions: DRUG: Epidural steroid injection (ESI)|DEVICE: Physical therapy for disc herniation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Clinical Study to Evaluate the Efficacy and Safety of Fimasartan in Patients With Mild to Moderate Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Fimasartan 60mg|DRUG: Fimasartan 120mg|DRUG: Candesartan cilexetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Different Intensities of Continuous Aerobic Exercises in Cardiac Rehab Phase 2
Status: COMPLETED
Conditions: Heart Diseases
Interventions: OTHER: Continuous Aerobic Moderate Intensity Exercise|OTHER: Continuous Aerobic (Mild intensity Exercise)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Randomized Trial:Arginine Butyrate Plus Standard Local Therapy in Patients With Refractory Sickle Cell Ulcers
Status: COMPLETED
Conditions: Skin Ulcers|Sickle Cell Anemia
Interventions: DRUG: Arginine Butyrate|OTHER: Standard local care dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Hypopressive Exercises Versus Pelvic-perineal Physiotherapy
Status: COMPLETED
Conditions: Pelvic Floor Disorders|Urinary Incontinence|Fecal Incontinence|Pelvic Pain
Interventions: OTHER: Hypopressive exercises|BEHAVIORAL: Therapeutic education.|OTHER: Pelvic-perineal physiotherapy|OTHER: Physical Therapy assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Aripiprazole (Abilify) Versus Placebo in Children With Subsyndromal Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Aripiprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases
Status: RECRUITING
Conditions: Metastatic Malignant Neoplasm in the Brain
Interventions: PROCEDURE: Brain Surgery|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|RADIATION: Stereotactic Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Different Clonidine Concentrations on Axillary Brachial Plexus Block With 1,5% Lidocaine
Status: COMPLETED
Conditions: Fascicular Block|Motor Activity|Pain, Postoperative|Latency Period
Interventions: DRUG: high Clonidine concentration|DRUG: low clonidine concentration|DRUG: Lidocaine|DRUG: Lidocaine 40 ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study VG2025 as a Single Agent and in Combination Therapy With Nivolumab in Subjects With Advanced Malignant Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: VG2025|DRUG: Nivolumab Injection [Opdivo]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Staccato Loxapine Multidose PK
Status: COMPLETED
Conditions: Volunteers on Chronic, Stable Antipsychotic Regimens
Interventions: DRUG: A - 10 mg loxapine q 4 h x 3 (30 mg total)|DRUG: B - 10 mg x 1, 5 mg x 2 loxapine q 4 h (20 mg total)|DRUG: C - 5 mg loxapine q 4 h x 3 (15 mg total)|DRUG: D - inhaled placebo q 4 h x 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Full-thickness Skin vs. Synthetic Mesh in the Repair of Large Incisional Hernia
Status: UNKNOWN
Conditions: Ventral Hernia|Postoperative Pain
Interventions: PROCEDURE: Ventral hernia repair using full thickness skin graft|PROCEDURE: Ventral hernia repair using mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Second-Line Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Metastatic Colorectal Cancer Who Have Received First-Line Chemotherapy and Bevacizumab
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: fluorouracil|DRUG: irinotecan hydrochloride|DRUG: leucovorin calcium|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet-Rich and Concentrated Platelet-Poor Plasma to Reduce Air Leak Post-Lobectomy: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Lung Cancer
Interventions: PROCEDURE: Standard post-lobectomy wound care plus use of PRP and PPPc prepared by GPS and Plasmax respectively|PROCEDURE: Standard post-lobectomy wound care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Compare Lenalidomide and Subcutaneous Daratumumab vs Lenalidomide and Dexamethasone in Frail Subjects With Previously Untreated Multiple Myeloma Who Are Ineligible for High Dose Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Daratumumab SC in combination with Lenalidomide|DRUG: Lenalidomide PO (25mg)|DRUG: Dexamethasone PO (20mg): days 1, 8, 15, 22 of each 28-day cycle, until progression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antibiotics In Modic Changes
Status: COMPLETED
Conditions: Low Back Pain|Modic Changes Type I or II Seen on MRI
Interventions: DRUG: Amoxicillin (Amoksicillintrihydrat)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Team-Based Goals and Incentives for Community-Based Health Workers to Promote Maternal and Child Health in Bihar, India
Status: COMPLETED
Conditions: Healthy
Interventions: BEHAVIORAL: Team-Based Goals and Incentives|OTHER: Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Taste Physiology in Healthy, Normal-weight Volunteers
Status: COMPLETED
Conditions: Exploratory Behavior
Interventions: DIETARY_SUPPLEMENT: Single intragastric instillation of 200 mL tap water via nasogastric tube|DIETARY_SUPPLEMENT: Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tube|DIETARY_SUPPLEMENT: Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tube|DIETARY_SUPPLEMENT: Single intragastric instillation of 0.017 g quinine in 200 mL tap water via nasogastric tube|DIETARY_SUPPLEMENT: Single intragastric instillation of 1 g monosodium glutamate in 200 mL tap water via nasogastric tube|DIETARY_SUPPLEMENT: Single intragastric instillation of 25 g glucose in 200 mL tap water via nasogastric tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: NORepinephrine-Maintaining-individuaALIZEd Blood Pressure
Status: COMPLETED
Conditions: Perioperative Myocardial Injury|Blood Pressure|Non-cardiac Surgery
Interventions: OTHER: standardized blood pressure management|OTHER: Individualized blood pressure management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: An Open-Label Study to Determine Safety , Tolerability, and Efficacy of Oral Lacosamide in Children With Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Lacosamide|DRUG: Lacosamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ameliorating Metabolic Profiling After Kidney Transplantation (AMPKT)
Status: UNKNOWN
Conditions: Kidney Transplantation|Metabolic Disorder|Metformin|Empagliflozin
Interventions: DRUG: SGLT2 inhibitor|DRUG: Metformin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of mRNA-based Urine Test (Xpert Bladder Cancer Monitor) in Predicting the Need for Second Look Biopsy After Transurethral Resection of Non Muscle-invasive Bladder Tumor.
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: PROCEDURE: Primary TURBT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Giving Epstein-Barr Virus (EBV) Specific Killer T Lymphocytes to Patients Who Have Had Donor Marrow Grafts
Status: COMPLETED
Conditions: Epstein-Barr Virus Infections
Interventions: BIOLOGICAL: EBV specific T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypofractionated vs. Conventional Regional Nodal Radiation Therapy for Patients With Invasive Breast Cancer
Status: RECRUITING
Conditions: Invasive Breast Carcinoma|Stage I Breast Cancer AJCC v7|Stage IA Breast Cancer AJCC v7|Stage IB Breast Cancer AJCC v7|Stage II Breast Cancer AJCC v6 and v7|Stage IIA Breast Cancer AJCC v6 and v7|Stage IIB Breast Cancer AJCC v6 and v7|Stage IIIA Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7
Interventions: RADIATION: Hypofractionated Radiation Therapy|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of N-methyl-D-aspartate (NMDA) Antagonist-induced Psychosis in Kids
Status: COMPLETED
Conditions: Psychoses, Substance-Induced
Interventions: DRUG: Ketamine|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Investigational Device Exemption Study to Determine the Safety and Efficacy of the Astron and Pulsar Stents
Status: COMPLETED
Conditions: Peripheral Artery Disease|Peripheral Vascular Disease
Interventions: DEVICE: Astron Stents|DEVICE: Pulsar Stents
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Therapeutic Education Program for Pregnant Women With a First Child Diagnosed With an Autism Spectrum Disorder
Status: NOT_YET_RECRUITING
Conditions: Child Psychiatry
Interventions: OTHER: The M.E.R. program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of an Automated Insulin Delivery System in Adult Participants With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: AID System|DRUG: Insulin Lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: PK and PD Profile of Dance 501 in Healthy, Non-diabetic Subjects With Mild to Moderate Asthma or COPD
Status: TERMINATED
Conditions: Safety and Tolerability
Interventions: DRUG: inhaled human insulin|DRUG: Insulin Lispro (Humalog U-100)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label Study to Evaluate the Safety of Various Dosing Regimens of MuSK-CAART for MuSK Myasthenia Gravis
Status: RECRUITING
Conditions: MuSK Myasthenia Gravis
Interventions: BIOLOGICAL: MuSK-CAART
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Soy Estrogen Alternative Study (SEA)
Status: COMPLETED
Conditions: Cardiovascular Diseases|Endometrial Hyperplasia|Heart Diseases|Menopausal Complaints|Uterine Diseases|Menopause
Interventions: DRUG: estrogens, conjugated|BEHAVIORAL: diet, soy proteins|BEHAVIORAL: dietary supplements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Rituximab on Mobilization With AMD3100 (Plerixafor) Plus G-CSF in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) or Hodgkin Disease (HD)
Status: COMPLETED
Conditions: Non-Hodgkin Lymphoma|Hodgkin Disease
Interventions: DRUG: G-CSF plus plerixafor|DRUG: G-CSF plus plerixafor|BIOLOGICAL: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT