pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Effect of Digital Storytelling and Sensory Integration on Children With Autism
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Digital Storytelling (DST)|BEHAVIORAL: Sensory Integration Therapy (SIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Observational Study to Investigate the Use of Sterilized Porcine Placental Tissue in the Treatment of Chronic VLU
Status: COMPLETED
Conditions: Ulcer Venous|Wound Heal
Interventions: DEVICE: InnovaMatrix® AC Sterilized, Porcine Placental Extracellular Matrix (ECM)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multi-omics Research of Idopathic Normal Pressure Hydrocephalus (iNPH)
Status: UNKNOWN
Conditions: Idiopathic Normal Pressure Hydrocephalus
Interventions: PROCEDURE: ventriculo-peritoneal shunt
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of Fluticasone Furoate/Vilanterol 100/25 Microgram (mcg) Inhalation Powder, Fluticasone Propionate/Salmeterol 250/50 mcg Inhalation Powder, and Fluticasone Propionate 250 mcg Inhalation Powder in Adults and Adolescents With Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone Furoate/Vilanterol 100/25 mcg via ELLIPTA inhaler|DRUG: Placebo inhalation powders via ELLIPTA inhaler|DRUG: Fluticasone Propionate/Salmeterol 250/50 mcg via ACCUHALER/DISKUS inhaler|DRUG: Placebo inhalation powder via ACCUHALER/DISKUS inhaler|DRUG: Fluticasone Propionate 250 mcg via ACCUHALER/DISKUS inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Insulin-plus-pramlintide Closed-loop Strategy to Regulate Glucose Levels Without Carbohydrate Counting
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: 27-hour inpatient intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Electrical Stimulation for mTBI
Status: COMPLETED
Conditions: Mild Traumatic Brain Injury (mTBI)|Post-traumatic Stress Disorder
Interventions: DEVICE: TES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Placement of Cesium-131 Permanent Interstitial Brachytherapy in Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Cesium 131
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BTL Emsella Chair Versus Sham for the Treatment of Stress Urinary Incontinence
Status: RECRUITING
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: BTL Emsella|DEVICE: Sham BTL Emsella
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Induction Chemotherapy With Gemcitabine and Cisplatin Followed by CCRT for Unresectable Pancreatic Carcinoma
Status: COMPLETED
Conditions: Pancreatic Carcinoma Non-resectable
Interventions: RADIATION: Induction chemotherapy followed by CCRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NPPV Added Inspiratory Muscle Training in Severe COPD
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease|Hypercapnic Respiratory Failure
Interventions: DEVICE: NPPV+IMT|DEVICE: NPPV|DEVICE: IMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Propranolol For Treating People With Post-Traumatic Stress Disorder
Status: TERMINATED
Conditions: Post-Traumatic Stress Disorder
Interventions: DRUG: Propanolol|DRUG: Placebo|BEHAVIORAL: Cognitive therapy workbook
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study of Etelcalcetide in the Treatment of Secondary Hyperparathyroidism (SHPT) in Patients With Chronic Kidney Disease (CKD) on Hemodialysis
Status: COMPLETED
Conditions: Hyperparathyroidism, Secondary
Interventions: DRUG: Etelcalcetide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erythropoietin Spinal Cord Compression Randomized Trial
Status: TERMINATED
Conditions: Nerve Compression Syndromes
Interventions: DRUG: Erythropoietin infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Platelet Aggregation Inhibition in Children on Clopidogrel (PICOLO)
Status: COMPLETED
Conditions: Congenital Heart Defects|Blood Platelet Disorders
Interventions: DRUG: Clopidogrel (SR25990)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Mother's Milk Messaging: Evaluation of a Bilingual Application (APP) to Support Initiation and Exclusive Breastfeeding in New Mothers
Status: COMPLETED
Conditions: Breastfeeding
Interventions: BEHAVIORAL: Social Support Group (Facebook)|BEHAVIORAL: Breastfeeding messages|BEHAVIORAL: Injury Prevention Messages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Sirolimus With Cyclophosphamide and Topotecan for Pediatric/Adolescent Relapsed and Refractory Solid Tumors
Status: COMPLETED
Conditions: Malignant Solid Tumor|Childhood Solid Tumor
Interventions: DRUG: Sirolimus, Cyclophosphamide, Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Re-Trabeculectomy Versus Ahmed Glaucoma Valve Implantation in Secondary Surgical Management of Patients With Refractory Glaucoma
Status: COMPLETED
Conditions: Refractory Primary Open Angle Glaucoma
Interventions: PROCEDURE: Implantation of Ahmed glaucoma tube shunt, and Trabeculectomy with MMC
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Acupuncture for Management of Balance Impairment in Patients With Parkinson's Disease
Status: TERMINATED
Conditions: Parkinson Disease|Acupuncture
Interventions: PROCEDURE: Acupuncture|PROCEDURE: Needle Insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Add-on Cangrelor in STEMI-triggered Cardiac Arrest
Status: UNKNOWN
Conditions: Cardiopulmonary Arrest With Successful Resuscitation|ACS - Acute Coronary Syndrome|Hypothermia, Induced
Interventions: DRUG: Cangrelor|DRUG: Placebo|DRUG: Prasugrel|DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Whey Protein Concentrate 40% Made of Milk of Immunized Cows to Aid in the Prevention of Relapse of Clostridium Difficile-Diarrhea
Status: TERMINATED
Conditions: Positive C-Diff Culture
Interventions: DRUG: MucoMilk product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Posttraumatic Stress Disorders in Police, Correctional Service Officers, and 911 Operators
Status: UNKNOWN
Conditions: Trauma and Stressor Related Disorders|Post-traumatic Stress Disorders|Adjustment Disorders|Acute Stress Disorder
Interventions: DRUG: Propranolol Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Concurrent Oral Calcium Carbonate Supplementation on Steady State Pharmacokinetics of Oral Raltegravir.
Status: RECRUITING
Conditions: Calcium Supplementation in HIV Patients Using Raltegravir
Interventions: DRUG: Raltegravir standard dosage of 1200 mg (two 600 mg tablets) orally once daily.|DRUG: Calcium carbonate antacid tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CYP3A4 Activity and Mineral Homeostasis
Status: COMPLETED
Conditions: Vitamin D and Calcium Homeostasis
Interventions: DRUG: Rifampin|DRUG: Clarithromycin|OTHER: Grapefruit Juice|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Safety and Efficacy Study of Ciclesonide Nasal Aerosol in Subjects 6-11 Years With Seasonal Allergic Rhinitis (SAR)
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Ciclesonide nasal aerosol 37 mcg|DRUG: ciclesonide nasal aerosol 74 mcg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading
Status: COMPLETED
Conditions: Osteoarthritis|Exercise
Interventions: OTHER: Exercise|OTHER: Non Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate Pharmacokinetics, Safety and Tolerability of MEDI0382 in Renal Impairment Subjects
Status: COMPLETED
Conditions: Renal Insufficiency
Interventions: DRUG: MEDI0382
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tenofovir, Emtricitabine, Efavirenz and Atazanavir Pharmacokinetics in the Aging HIV-Infected Population
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: tenofovir/emtricitabine/efavirenz (TDF/FTC/EFV)|DRUG: tenofovir/emtricitabine (TDF/FTC)|DRUG: Atazanavir (ATV)|DRUG: Ritonavir|PROCEDURE: Phlebotomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Targeted Busulfan, Fludarabine Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Chronic Granulomatous Disease(CGD)
Status: UNKNOWN
Conditions: Chronic Granulomatous Disease
Interventions: DRUG: Busulfan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Change in OHRQOL Following Minimally Invasive Treatment of Anterior Teeth in Children With MIH
Status: COMPLETED
Conditions: Molar Incisor Hypomineralization
Interventions: PROCEDURE: Minimal invasive restorative treatment|PROCEDURE: Fluoride gel application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ROSSINI 2 - Reduction of Surgical Site Infection Using Several Novel Interventions
Status: UNKNOWN
Conditions: Surgical Site Infection|Surgical Wound Infection|Surgery--Complications|Surgery
Interventions: DRUG: 2% alcoholic chlorhexidine skin prep (SKIN PREP)|DEVICE: Iodophor Antimicrobial Incise Drapes (DRAPE)|DEVICE: Gentamicin-impregnated implants/ sponges (SPONGE)|OTHER: NONE (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Predicting Emergency Department Delirium With an Interactive Customizable Tablet to Prevent Repeat Visits
Status: UNKNOWN
Conditions: Delirium
Interventions: DIAGNOSTIC_TEST: PrEDICT game score
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Sub-Occipital MIT With and Without HR Agonist Contraction of Hamstrings in Neck Pain Patients With Hamstring Tightness
Status: UNKNOWN
Conditions: Neck Pain Patients With Hamstring Tightness
Interventions: OTHER: Sub Occipital Muscle Inhibition|OTHER: Sub Occipital Inhibition with Hold Relax Agonist Contraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Outcomes Between Intraosseous Femoral and Tibial Injection in Simultaneous Bilateral Total Knee Arthroplasty Patients
Status: RECRUITING
Conditions: Pain, Postoperative
Interventions: DRUG: Multimodal Intraosseous Femoral Injection|DRUG: Multimodal Intraosseous Tibial Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IUA Committee Research Project on the Management of TASC C and D Aortoiliac Lesions
Status: NOT_YET_RECRUITING
Conditions: Aortoiliac Atherosclerosis|Aortoiliac Occlusive Disease|Aortoiliac Atherosclerosis With Gangrene|Aortoiliac Atherosclerosis Without Gangrene|Aortoiliac Obstruction|Peripheral Arterial Disease|Peripheral Vascular Diseases
Interventions: PROCEDURE: Aortobifemoral bypass|PROCEDURE: aortoiliac stenting
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transarticular Lateral Release Versus Percutaneous Lateral Release for Hallux Valgus
Status: NOT_YET_RECRUITING
Conditions: Hallux Valgus
Interventions: PROCEDURE: Distal soft tissue procedure with TALR|PROCEDURE: Distal soft tissue procedure with PCLR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation Of The Effect Of Morphological Structure On Dilatational Tracheostomy Interference Location And Complications
Status: COMPLETED
Conditions: Tracheostomy Complication
Interventions: PROCEDURE: Percutaneous dilatational tracheostomy|DEVICE: Bronchoscopy|DEVICE: ultrasonography|DIAGNOSTIC_TEST: Bronchoscopy application|DIAGNOSTIC_TEST: Ultrasound examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Role of Lactate in Lipolysis and Catabolism in Humans
Status: COMPLETED
Conditions: Hyperlactatemia|Healthy|Lactate
Interventions: DRUG: Na-lactate|DRUG: Sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study to Assess the Pharmacokinetics, Safety and Tolerability of Sitagliptin in Adolescents (0431-081)
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Sitagliptin phosphate|DRUG: Comparator: matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acceptance and Performance of the CP1170 Sound Processor in Experienced Adult Cochlear Implant Recipients (POLAR)
Status: COMPLETED
Conditions: Hearing Impairment
Interventions: DEVICE: CP1170 sound processor|DEVICE: CP1150 Sound processor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Safety and Efficacy of a Single Dose of STI-2020 (COVI-AMG™) to Treat COVID-19
Status: WITHDRAWN
Conditions: Covid19
Interventions: BIOLOGICAL: COVI-AMG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: HPV-SAVE_Merck_Sub-Study for Preventing Recurrence of HSIL
Status: NOT_YET_RECRUITING
Conditions: Anal Intraepithelial Neoplasia|Anal Cancer|Human Papilloma Virus
Interventions: DRUG: 9-valent HPV vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Technology-based Interventions for the Improvement of Cognitive Processes in ADHD.
Status: COMPLETED
Conditions: ADHD, Deficits in Motor Control and Perception
Interventions: DEVICE: neurocognitive therapy based on new technologies|OTHER: conventional neurocognitive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Serum Level of Calpains Product as a Novel Biomarker of Acute Lung Injury Following Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Lung Injury, Acute
Interventions: DIAGNOSTIC_TEST: blood cell analysis, blood gas surveillance, chest radiograph and echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Vatalanib in Treating Patients With Primary or Secondary Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: DRUG: vatalanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vestibulopathy With Vestibulo Ocular Reflex (VOR) Gain Deficit
Status: UNKNOWN
Conditions: Vestibulopathy, Acute Peripheral
Interventions: OTHER: physical therapy program (group)|OTHER: physical therapy program (computerized exercises)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study in Healthy Male Subjects to Investigate Whether Ketoconazole Affects Plasma Exposure of BI 113823
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 113823 + Ketokonazole|DRUG: BI 113823
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nilotinib in TKI Resistant or Intolerant Patients With Metastatic Mucosal, Acral, or Chronically Sun Damaged Melanoma
Status: COMPLETED
Conditions: Mucosal Lentiginous Melanoma|Acral Melanoma|Melanoma
Interventions: DRUG: Nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Blinded Study To Examine The Ability Of PF-610,355 To Open The Airways In Asthmatic Patients.
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: PF-610,355|DRUG: Salmeterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: In-house Produced PMMA- Versus PEEK-cages
Status: COMPLETED
Conditions: Cervical Disc Degeneration|Cervical Stenosis
Interventions: DEVICE: Implantation of a PEEK-cage|DEVICE: PMMA-cage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 15 mg Mirtazapine Orally Disintegrating Tablets, Fasting
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Mirtazapine 15 mg (Orally Disintegrating) Tablets|DRUG: REMERON SolTab® 15 mg Orally Disintegrating Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Single Dose Texas 2017 (H3N2) Challenge Study
Status: NOT_YET_RECRUITING
Conditions: Influenza Viral Infections
Interventions: BIOLOGICAL: Influenza A/Texas/71/2017 (H3N2)|BIOLOGICAL: Sham placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: High Dose Multiple Site Injection of Botox Versus Lateral Sphincterotomy in Chronic Analfissure
Status: COMPLETED
Conditions: Chronic Anal Fissure
Interventions: PROCEDURE: botox injection in intersphincteric space|PROCEDURE: lateral internal sphincterotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of the Efficacy and Safety of Lidoderm Patch in the Treatment of Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: DRUG: Lidoderm®|DRUG: Lidoderm®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Busulfan and Etoposide Followed by Peripheral Blood Stem Cell Transplant and Low-Dose Aldesleukin in Treating Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Childhood Acute Myeloid Leukemia in Remission|Recurrent Adult Acute Myeloid Leukemia|Recurrent Childhood Acute Myeloid Leukemia
Interventions: DRUG: busulfan|DRUG: etoposide|BIOLOGICAL: aldesleukin|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Exercise in Smokers With Schizophrenia
Status: COMPLETED
Conditions: Tobacco Dependence|Cigarette Craving|Smoking Behavior
Interventions: BEHAVIORAL: Exercise|BEHAVIORAL: passive control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Both Metabolic and Functional Effects Induced by Two Neuromuscular Electrical Stimulation Protocols: A Comprehensive Approach Using Magnetic Resonance Imaging and Spectroscopy
Status: UNKNOWN
Conditions: Healthy
Interventions: DEVICE: magnetic resonance imaging (MRI)|DEVICE: 31-phosphorous magnetic resonance spectroscopy (MRS-P31)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Measurement of Tricuspid Regurgitation Volume for Assessment of Tricuspid Regurgitation Using 3D Transesophageal Echocardiography
Status: WITHDRAWN
Conditions: Tricuspid Regurgitation
Interventions: OTHER: Transesophageal echocardiograpgy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Low Dose Mosunetuzumab for the Treatment of Patients With Indolent B-Cell Lymphoma
Status: RECRUITING
Conditions: Ann Arbor Stage II Follicular Lymphoma|Ann Arbor Stage II Marginal Zone Lymphoma|Ann Arbor Stage III Follicular Lymphoma|Ann Arbor Stage III Marginal Zone Lymphoma|Ann Arbor Stage IV Follicular Lymphoma|Ann Arbor Stage IV Marginal Zone Lymphoma|Grade 1 Follicular Lymphoma|Grade 2 Follicular Lymphoma|Grade 3a Follicular Lymphoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Mosunetuzumab|PROCEDURE: Positron Emission Tomography|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Safety of Immediate-release Tolvaptan in Subjects With Autosomal Dominant Polycystic Kidney Disease
Status: COMPLETED
Conditions: Polycystic Kidney, Autosomal Dominant
Interventions: DRUG: Tolvaptan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hospital-to-Home Transitional Care Interventions (H2H-TCI) Children/Youth With Special Health Care Needs (CYSHCN)
Status: NOT_YET_RECRUITING
Conditions: Health Care|Pediatrics|Transitional Care|Comparative Effectiveness|Family Engagement
Interventions: BEHAVIORAL: Focused Dose Hospital-to-Home Transitional Care Interventions|BEHAVIORAL: Extended Dose Hospital-to-Home Transitional Care Interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: STRETCH Study: Effect of Distensibility on Endothelial-Dependent Vasoreactivity in Patients With ISH
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DRUG: ALT-711 (alagebrium chloride)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Gleevec and Weekly Paclitaxel in Patients Aged 70 or Older With Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Imatinib mesylate|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Euglycemia After Antenatal Late Preterm Steroids, the E-ALPS Study
Status: COMPLETED
Conditions: Pregnancy Preterm|Neonatal Hypoglycemia|Hyperglycemia Drug Induced
Interventions: OTHER: Maternal glycemic control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Optimizing Acute Malnutrition Management in Children Aged 6 to 59 Months in Democratic Republic of Congo
Status: COMPLETED
Conditions: Severe Acute Malnutrition|Moderate Acute Malnutrition|Child Malnutrition|Acute Malnutrition|Congo, The Democratic Republic of the|Africa|Randomized Clinical Trial
Interventions: OTHER: Nutritional Strategy - OptiMA|OTHER: Effective nutritional standard strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Three Instructional Interventions for Prehospital Cervical Spinal Immobilization by Laypeople
Status: COMPLETED
Conditions: Cervical Vertebra Injury|Cervical Vertebra Fracture
Interventions: BEHAVIORAL: Audio kit|BEHAVIORAL: Instructional flashcard (version 1)|BEHAVIORAL: In-person training|BEHAVIORAL: Instructional flashcard (version 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: 64Cu DOTA-Trastuzumab PET/CT in Studying Patients With Gastric Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Adenocarcinoma of the Gastroesophageal Junction|Diffuse Adenocarcinoma of the Stomach|Intestinal Adenocarcinoma of the Stomach|Mixed Adenocarcinoma of the Stomach|Recurrent Gastric Cancer|Stage IA Gastric Cancer|Stage IB Gastric Cancer|Stage IIA Gastric Cancer|Stage IIB Gastric Cancer|Stage IIIA Gastric Cancer|Stage IIIB Gastric Cancer|Stage IIIC Gastric Cancer|Stage IV Gastric Cancer
Interventions: RADIATION: copper Cu 64-DOTA-trastuzumab|DEVICE: positron emission tomography|OTHER: laboratory biomarker analysis|PROCEDURE: Computed Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Locoregional Blocks for Breast Cancer Surgeries
Status: RECRUITING
Conditions: Analgesia
Interventions: PROCEDURE: erector spinae block|PROCEDURE: retrolaminar block|PROCEDURE: serratus anterior block|PROCEDURE: pectoral nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Effect of Venetoclax on Participants Receiving a Covalent Bruton's Tyrosine Kinase Inhibitor (cBTKi) for First-Line Chronic Lymphocytic Leukemia (1L CLL) to Achieve Deep Durable Remissions to Allow Off-Treatment Period
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Venetoclax|DRUG: cBTKi Monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of App-based Positive Psychological Intervention on Patients Newly Diagnosed With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: App-based Positive Psychological Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of IPI-145 in Combination With Rituximab or Bendamustine/Rituximab in Hematologic Malignancies
Status: COMPLETED
Conditions: Lymphoma|Chronic Lymphocytic Leukemia|Non-Hodgkin Lymphoma|T-cell Lymphoma
Interventions: DRUG: IPI-145|DRUG: Rituximab|DRUG: Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 7 Tesla MRI Neuroimaging in Testicular Cancer Patients With Hypogonadism and on Androgen Replacement Therapy
Status: RECRUITING
Conditions: Hypogonadism|Malignant Testicular Germ Cell Tumor
Interventions: PROCEDURE: 7 Tesla Magnetic Resonance Imaging|PROCEDURE: Biospecimen Collection|PROCEDURE: Cognitive Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lacto-fermented Sauerkraut in the Treatment of Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: OTHER: Raw sauerkraut|OTHER: Pasteurized sauerkraut
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-traumatic Stress, Signs of Depression and Burnout Syndrome Among Nursing Home Staff in Occitanie During the COVID-19 Pandemic
Status: COMPLETED
Conditions: Covid19|Post Traumatic Stress Disorder|Anxiety|Depressive Disorder|Substance Use Disorders
Interventions: OTHER: Cognitive tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intravenous Immunoglobulins for Post-Polio Syndrome
Status: COMPLETED
Conditions: Post-polio Syndrome
Interventions: BIOLOGICAL: intravenous immunoglobulins|BIOLOGICAL: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving New Learning and Memory in Traumatic Brain Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: memory retraining exercises|BEHAVIORAL: placebo control memory exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Skilled Motor Training and tDCS to Improve Leg Function After Spinal Cord Injury
Status: TERMINATED
Conditions: Spinal Cord Injury
Interventions: DEVICE: Transcranial direct current stimulation + step training|BEHAVIORAL: Sham transcranial direct current stimulation + step training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Paced And Sensed Electrical Delay in CRT Therapy (PASED CRT)
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: DEVICE: CRT Algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Yoga for Aromatase Inhibitor-related Knee Pain Relief in Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer|Aromatase Inhibitor|Yoga|Knee Pain
Interventions: OTHER: yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The BRAINFOOD Trial to Prevent Recurrent Hepatic Encephalopathy.
Status: COMPLETED
Conditions: Cirrhosis|Ascites|Liver Diseases|Frailty|Sarcopenia|Hepatic Encephalopathy
Interventions: OTHER: Medically-tailored meals (MTM)|DIETARY_SUPPLEMENT: Protein supplements|BEHAVIORAL: Nutrition education handout
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Tigecycline vs. Levofloxacin in Subjects Hospitalized With Community-Acquired Pneumonia
Status: COMPLETED
Conditions: Community-Acquired Infections|Bacterial Pneumonia|Cross Infection
Interventions: DRUG: Tigecycline|DRUG: Levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Adequacy of Anesthesia Monitoring With Standard Clinical Practice During Routine General Anesthesia
Status: COMPLETED
Conditions: Surgical Procedure, Unspecified
Interventions: DEVICE: AoA Monitoring|DEVICE: Routine (Standard) Anesthesia Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Whole Body Vibration for the Improvement of Health and Functioning in Participants With Chemotherapy-Induced Peripheral Neuropathy
Status: COMPLETED
Conditions: Chemotherapy-Induced Peripheral Neuropathy|Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: BEHAVIORAL: Whole Body Vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dexmedetomidine in Pediatric Cardiac Surgery
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: DRUG: Dexmedetomidine|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Application of Spaghetti Knotting Technology in Single-hole Laparoscopic Suturing Instructional Program on the Basis of Multidirectional Stitching Technology.
Status: COMPLETED
Conditions: Knotting Methods|Single-port Laparoscopic Surgery
Interventions: OTHER: knotting methods
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Flutiform® Compared With Seretide® in the Treatment of COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Flutiform 500/20 µg BID|DRUG: Flutiform 250/10 µg BID|DRUG: Seretide Accuhaler 50/500 µg BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Creatine Supplementation in Rett Syndrome
Status: COMPLETED
Conditions: Rett Syndrome
Interventions: DIETARY_SUPPLEMENT: Creatine monohydrate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Pharmacokinetics of Grazoprevir (MK-5172) and Elbasvir (MK-8742) in Participants With Renal Insufficiency (MK-5172-050)
Status: COMPLETED
Conditions: Chronic Hepatitis C|Renal Impairment
Interventions: DRUG: Grazoprevir|DRUG: Elbasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunological Comparison of AIT and SCIT Immunotherapy Against Grass Pollen
Status: COMPLETED
Conditions: Allergic Rhinitis Due to Grass Pollens
Interventions: DRUG: ALK Grazax 75,000 SQ-T "Phleum pratense"|DRUG: ALK AluTard 225 "Phleum pratense"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Extensive Stage Lung Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8
Interventions: BIOLOGICAL: Atezolizumab|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|BIOLOGICAL: Durvalumab|PROCEDURE: Echocardiography|DRUG: Iadademstat|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Multigated Acquisition Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Audio Recording During Laparoscopic Surgery
Status: COMPLETED
Conditions: Perioperative/Postoperative Complications|Laparoscopy|Communication|Communication, Multidisciplinary
Interventions: OTHER: Audio-recoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Pelvimetric Measurements Between MRI and Low-dose Stereoradiography (EOS® Imaging System)
Status: COMPLETED
Conditions: Breech Fetal Presentation
Interventions: OTHER: Pelvimetric measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mitochondrial dysfUnction: a Key Player in Doxorubicin-induced Skeletal and Cardiac muscLE Damage
Status: NOT_YET_RECRUITING
Conditions: Doxorubicin Induced Cardiomyopathy|Chemotherapeutic Toxicity|B-cell Lymphoma|T-cell Lymphoma
Interventions: DIAGNOSTIC_TEST: 31-MRS at 7 Tesla (T)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Symptomatic Trigeminal Neuralgia Attributed to Multiple Sclerosis - a Prospective Study in 60 Patients
Status: COMPLETED
Conditions: Trigeminal Neuralgia|Multiple Sclerosis|Pain, Neuropathic
Interventions: DRUG: Carbamazepine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Manual Treatment and Proprioceptive Neuromusculer Fasilitation Techniques for Patients With Adhesive Capsulitis
Status: UNKNOWN
Conditions: Adhesive Capsulitis of Shoulder
Interventions: OTHER: Manual treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Tolerability of a Single Dose Administration of CVT-301 (Levodopa Inhalation Powder)
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: CVT-301, LIP|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: C2Rx Hemofiltration Treatment in Severe or Critically Ill Adults With COVID-19
Status: WITHDRAWN
Conditions: Continuous Renal Replacement Therapy|Pulmonary Edema|COVID-19
Interventions: DEVICE: C2Rx|OTHER: Standard of Care (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Tolerability, Pharmacokinetics and Pharmacodynamics Study of HEC74647 in HCV-infected Subjects
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: HEC74647PA capsule|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pegasys (Peginterferon Alfa-2a) Added to Nucleos(t)Ide Analogue Treatment in Participants With HBeAg-Negative Chronic Hepatitis B Genotype D Showing Stable Hepatitis B Virus (HBV) Deoxyribonucleic Acid (DNA) Suppression
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Pegylated Interferon (Peginterferon) Alfa-2a|DRUG: Nucleos(t)ide Analogues (NA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Interscalene Block on Intracranial Pressure
Status: UNKNOWN
Conditions: Brachial Plexus Block|Intracranial Pressure Increase
Interventions: PROCEDURE: Interscalene brachial plexus block
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Vaginal Misoprostol In Medical Treatment of First Trimester Missed Miscarriage
Status: UNKNOWN
Conditions: Miscarriage
Interventions: DRUG: Vaginal Misoprostol 600 mcg|DRUG: Vaginal Misoprostol 800 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Riluzole Oral Soluble Film (ROSF) Swallowing Safety in Amyotrophic Lateral Sclerosis (ALS)
Status: TERMINATED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Riluzole Oral Soluble film (ROSF) 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Use of a Visual Pedagogy and Structure With Children With Autism for Routine Physical Exams
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: OTHER: Treatment: Physical Exam with Visual Pedagogy and Structure|OTHER: Control: Physical Exam without Visual Pedagogy and Structure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CHUSPAN PAN BP Treatment of Polyarteritis Nodosa and Microscopic Polyangiitis Without Poor-Prognosis Factors
Status: UNKNOWN
Conditions: Polyarteritis Nodosa|Microscopic Polyangiitis
Interventions: DRUG: azathioprine|DRUG: cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic nCPAP Following Bowel Surgery (Bio-REB File 11-27)
Status: COMPLETED
Conditions: Postoperative Pulmonary Atelectasis|Surgery
Interventions: DEVICE: nCPAP|DEVICE: Low Flow Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate Efficacy, Safety and Tolerability of JTE-051 in Subjects With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: JTE-051|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TF2- Small Cell Lung Cancer Radio Immunotherapy
Status: COMPLETED
Conditions: Small Cell Lung Cancer|CEA-expressing Non Small Cell Lung Carcinoma (NSCLC)
Interventions: DRUG: Antibody TF2|RADIATION: IMP-288-Lutetium|RADIATION: IMP-288-Indium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiotherapy of the Pelvic Floor in Women With Deep Infiltrating Endometriosis
Status: UNKNOWN
Conditions: Endometriosis
Interventions: DIAGNOSTIC_TEST: assessment of symptoms at the first medical examination|PROCEDURE: pelvic floor physiotherapy|PROCEDURE: standard care protocol|DIAGNOSTIC_TEST: assessment of symptoms after four months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Injection of Recombinant Human Tissue-type Plasminogen Activator Derivative for Acute Pulmonary Embolism(rPA)
Status: UNKNOWN
Conditions: Acute Pulmonary Embolism
Interventions: DRUG: Recombinant human tissue-type plasminogen activator derivative|DRUG: Recombinant human tissue-type plasminogen activator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cervical Cancer Detection Using Optical Spectroscopy
Status: RECRUITING
Conditions: Cervical Cancer
Interventions: DEVICE: Optical Spectroscopy Bench-Top System|DEVICE: Portable Optical Spectrometer|DEVICE: Transvaginal colposcope
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial of an Investigational Drug After Rejecting the Relapse of an Allogeneic Transplant
Status: NOT_YET_RECRUITING
Conditions: Multiple Myeloma|Allogeneic Stem Cell Transplantation
Interventions: GENETIC: CARTemis-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-Arm Phase II Exploratory Clinical Study of Pemigatinib in the Treatment of Advanced Gastrointestinal Cancer (Excluding Biliary Tract Cancer) Patients With FGFR Alterations Who Have Failed Standard Therapy
Status: RECRUITING
Conditions: Gastrointestinal Cancer
Interventions: DRUG: Pemigatinib Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing CC-486 (Oral Azacitidine) Plus the Standard Drug Therapy in Patients 75 Years or Older With Newly Diagnosed Diffuse Large B Cell Lymphoma
Status: RECRUITING
Conditions: Ann Arbor Stage III Diffuse Large B-Cell Lymphoma|Ann Arbor Stage IIX (Bulky) Diffuse Large B-Cell Lymphoma|Ann Arbor Stage IV Diffuse Large B-Cell Lymphoma|Diffuse Large B-Cell Lymphoma Activated B-Cell Type|Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation|Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type|Diffuse Large B-Cell Lymphoma, Not Otherwise Specified|EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified|Grade 3b Follicular Lymphoma|HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified|High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements|High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements|High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements|High Grade B-Cell Lymphoma, Not Otherwise Specified|Intravascular Large B-Cell Lymphoma|Lymphoplasmacytic Lymphoma|Nodular Lymphocyte Predominant B-Cell Lymphoma|Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type|T-Cell/Histiocyte-Rich Large B-Cell Lymphoma|Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma|Transformed Marginal Zone Lymphoma to Diffuse Large B-Cell Lymphoma
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Cyclophosphamide|DRUG: Doxorubicin Hydrochloride|DRUG: Oral Azacitidine|DRUG: Prednisone|OTHER: Questionnaire Administration|BIOLOGICAL: Rituximab|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT