pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Zanubrutinib Plus BR in Newly Diagnosed Symptomatic WM
Status: RECRUITING
Conditions: Waldenstrom Macroglobulinemia
Interventions: DRUG: Zanubrutinib, Bendamustine and Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Umbrella Biomarker-Guided Therapy in NPC
Status: NOT_YET_RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: GP+DDP|DRUG: Palbociclib|RADIATION: Intensity-modulated radiotherapy|DRUG: PD-1 blocking antibody|DRUG: Galunisertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stool Transplant to Control Treatment-related Diarrhea
Status: ACTIVE_NOT_RECRUITING
Conditions: Fecal Microbiota Transplantation (FMT)
Interventions: BIOLOGICAL: Fecal Microbiota Transplantation (FMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RISE Adult Medication Study
Status: COMPLETED
Conditions: Prediabetes|Type 2 Diabetes
Interventions: DRUG: Metformin|DRUG: Liraglutide|DRUG: Glargine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Directly Observed and Long-term Varenicline
Status: COMPLETED
Conditions: Tobacco Use Disorder|Opioid-use Disorder
Interventions: DRUG: Long-Term Varenicline|DRUG: Short-Term Varenicline|BEHAVIORAL: Directly Observed Therapy|BEHAVIORAL: Self Administered Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preference Between Two Autoinjectors in Patients With Rheumatoid Arthritis and Plaque Psoriasis Treated With Etanercept
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Plaque Psoriasis
Interventions: DRUG: Etanercept via Autoinjector A|DRUG: Etanercept via Autoinjector B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stimulant Versus Nonstimulant Medication for Attention Deficit Hyperactivity Disorder in Children
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: Atomoxetine|DRUG: Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Ultrafiltration in Treating People With Acute Decompensated Heart Failure and Cardiorenal Syndrome (The CARRESS Study)
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Stepped pharmacologic care|DEVICE: Ultrafiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Plus Radiation Therapy Followed by Surgery in Treating Patients With Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Sarcoma
Interventions: BIOLOGICAL: filgrastim|DRUG: dacarbazine|DRUG: doxorubicin hydrochloride|DRUG: ifosfamide|DRUG: mesna|PROCEDURE: conventional surgery|RADIATION: brachytherapy|RADIATION: intraoperative radiation therapy|RADIATION: radioisotope therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: CCR2 AAA Pilot Study
Status: TERMINATED
Conditions: Abdominal Aortic Aneurysm (AAA)
Interventions: DIAGNOSTIC_TEST: Aortoiliac Occlusive Disease Group - PET-CT imaging with injection of 64Cu-DOTA-ECL1i|DIAGNOSTIC_TEST: AAA Group- PET-CT imaging with injection of 64Cu-DOTA-ECL1i
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Audiological Benefit With Non-implantable Bone Conduction Hearing Systems
Status: COMPLETED
Conditions: Hearing Loss, Conductive
Interventions: DEVICE: Non-invasive bone conduction hearing aid A|DEVICE: Non-invasive bone conduction hearing aid B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ga-68 Prostate Specific Membrane Antigen PET/CT in Gliomas
Status: NOT_YET_RECRUITING
Conditions: Glioma|Astrocytoma|Anaplastic Astrocytoma|Oligodendroglioma|Glioblastoma Multiforme
Interventions: DIAGNOSTIC_TEST: PSMA PET-CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Analgesic Effect of Maternal Breast Milk Odor in Preterm Neonates: a Randomised Controlled Trial
Status: UNKNOWN
Conditions: Neonates Analgesy
Interventions: OTHER: maternal breast milk odor|OTHER: no odor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fu's Subcutaneous Needling Treatment for Biceps Tendinopathy
Status: COMPLETED
Conditions: Bicep Tendinitis
Interventions: PROCEDURE: Fu's subcutaneous needling(FSN)|PROCEDURE: Transcutaneous Electric Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study With Quadrivalent Recombinant Influenza Vaccine (RIV4) Compared With Egg-Based Quadrivalent Influenza Vaccine (IIV4) in Participants Aged 3 to 8 Years
Status: TERMINATED
Conditions: Influenza Immunization
Interventions: BIOLOGICAL: Recombinant influenza vaccine (RIV4)|BIOLOGICAL: Quadrivalent influenza vaccine (IIV4)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Feeding Intervention for Infants With Crying
Status: TERMINATED
Conditions: Crying
Interventions: OTHER: Milk based infant formula with probiotic|OTHER: Milk based infant formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: S4 :Trial Of Fully Closed-Loop Ventilation In ICU.
Status: COMPLETED
Conditions: Intensive Care Patients Invasively Ventilated
Interventions: DEVICE: INTELLIVENT ASV FULLY CLOSED-LOOP VENTILATION|DEVICE: Conventionals Modes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Correlation Between In-vivo Anatomy of Corneal Dystrophies as Assessed by High- Resolution Optical Coherence Tomography (OCT) Measurement and Histological Examination
Status: UNKNOWN
Conditions: Corneal Dystrophy
Interventions: DEVICE: Ultrahigh resolution Spectral Domain OCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Human Controlled Infection Study With Neisseria Lactamica in Malian Adults
Status: UNKNOWN
Conditions: Meningitis, Meningococcal
Interventions: BIOLOGICAL: Intranasal inoculation with Neisseria lactamica
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: High Altitude Residents With High Altitude Pulmonary Hypertension (HAPH), 6MWT Assessed at High Altitude (3200m) vs Low Altitude (760m)
Status: NOT_YET_RECRUITING
Conditions: High Altitude Pulmonary Hypertension
Interventions: OTHER: 6-minute walk test (6MWT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients of Different Ages With Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: paclitaxel albumin-stabilized nanoparticle formulation|OTHER: pharmacological study|OTHER: physiologic testing|OTHER: questionnaire administration|OTHER: study of socioeconomic and demographic variables|PROCEDURE: cognitive assessment|PROCEDURE: psychosocial assessment and care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Varespladib in Patients Hospitalized With Severe COVID-19
Status: TERMINATED
Conditions: Coronavirus Disease 2019|Disease Caused by Severe Acute Respiratory Syndrome Coronavirus 2
Interventions: DRUG: Varespladib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Home Versus Office Biofeedback Therapy for Fecal Incontinence
Status: COMPLETED
Conditions: Fecal Incontinence
Interventions: BEHAVIORAL: biofeedback therapy|DEVICE: Home Biofeedback therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Percocet vs. Bupivicaine for Toothaches in the ED
Status: TERMINATED
Conditions: Toothache
Interventions: DRUG: Acetaminophen/Oxycodone (Oral analgesic)|DRUG: Bupivicaine (Injectable local anesthetic)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, Pharmacodynamic, and Pharmacokinetics Study of Olipudase Alfa in Patients With Acid Sphingomyelinase Deficiency
Status: COMPLETED
Conditions: Sphingomyelin Lipidosis
Interventions: DRUG: placebo (saline)|DRUG: GZ402665
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Robotic Therapy and Transcranial Direct Current Stimulation in Patients With Stroke
Status: TERMINATED
Conditions: Stroke
Interventions: DEVICE: Robotic Therapy|DEVICE: Active tDCS|DEVICE: Sham tDCS|OTHER: Physical Therapy|OTHER: Occupational Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Neonatal Morbidity by Discontinuing Oxytocin During the Active Phase of 1st Stage of Labor
Status: COMPLETED
Conditions: Neonatal Morbidity
Interventions: DRUG: discontinuation of oxytocin administration|DRUG: continuation of oxytocin administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Open Milligan-Morgan Haemorrhoidectomy Versus Laser Closed Haemorrhoidectomy
Status: COMPLETED
Conditions: Haemorrhoids|Haemorrhoidectomy|Milligan-Morgan Haemorrhoidectomy|Open Haemorrhoidectomy
Interventions: PROCEDURE: Laser Haemorrhoidectomy|PROCEDURE: Laser Haemorrhoidectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ghrelin Regulation and Structure: Effect of Thiazolidinedione Therapy on Ghrelin
Status: TERMINATED
Conditions: Obesity|Insulin Resistance
Interventions: DRUG: placebo|DRUG: pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tolerance of nHFPV Versus nCPAP in Neonatal Respiratory Distress
Status: UNKNOWN
Conditions: Neonatal Respiratory Distress
Interventions: DEVICE: Nasal continuous airway positive pressure (nCPAP)|DEVICE: Nasal high frequency percussive ventilation (nHFPV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Comparison of Single-Injection Serratus Anterior Plane Block With Ropivacaine Versus Local Infiltration of Anaesthetic After Breast Surgery
Status: RECRUITING
Conditions: Mastectomy; Lymphedema
Interventions: PROCEDURE: SAPB|PROCEDURE: Local Injection Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Transplant w/Laronidase for Hurler
Status: COMPLETED
Conditions: Mucopolysaccharidosis I|Hurler Syndrome
Interventions: PROCEDURE: Stem Cell Transplant|DRUG: Laronidase ERT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Exploring Camrelizumab in the Treatment of Colorectal Mucinous Adenocarcinoma(MAC)
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: Carilizumab + anti-angiogenic TKIs (available with fuquitinib, rigofenib, apatinib, etc.)|DRUG: Carilizumab + anti-angiogenic TKIs (available with fuquitinib, rigofenib, apatinib, etc.)+Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MabionCD20® Compared to MabThera® in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of High-dose Tirofiban During Coronary Angioplasty
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: tirofiban|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Entrectinib as a Single Agent in Upfront Therapy for Children <3 Years of Age With NTRK1/2/3 or ROS1-FUSED CNS Tumors
Status: RECRUITING
Conditions: High Grade Glioma|CNS Tumor
Interventions: DRUG: Entrectinib|DRUG: Cyclophosphamide|DRUG: Etoposide|DRUG: Carboplatin|BIOLOGICAL: G-CSF|BIOLOGICAL: Pegfilgrastim|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Soluble Fiber to Reduce Post-prandial Glycemic Excursion in Adults With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis-related Diabetes|Cystic Fibrosis
Interventions: DIETARY_SUPPLEMENT: Soluble fiber supplementation|DIETARY_SUPPLEMENT: Placebo (for fiber supplementation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Point-of-Care Bedside Lung Ultrasound Examination Advanced Trial Protocol
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome
Interventions: DEVICE: Linear Ultrasonic Sounder|DEVICE: Bedside X-ray Machine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Clinical Study of B007 in the Treatment of Primary Membranous Nephropathy.
Status: RECRUITING
Conditions: Primary Membranous Nephropathy
Interventions: DRUG: B007|DRUG: Cyclosporin Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Olive Oil and Palm Oil-enricHed chOCOlate Spreads (CHOCO) in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Diet
Interventions: DIETARY_SUPPLEMENT: Extra Virgin Olive Oil-enriched chocolate spread|DIETARY_SUPPLEMENT: Palm Oil-enriched chocolate spread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Pre and Postoperative Dextromethorphan Reduce Post-tonsillectomy Pain in Children?
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Dextromethorphan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VitamIN D Treating patIents With Chronic heArT failurE
Status: COMPLETED
Conditions: Chronic Heart Failure
Interventions: DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of an Automated Insulin Delivery System Compared to Sensor Augmented Pump at Patients With Type 1 Diabetes (T1D)
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: MD-Logic-Automated Insulin Delivery System|DEVICE: MiniMed Paradigm® Veo™ System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Action of Amantadine on Post-Stroke Aphasic Patients
Status: COMPLETED
Conditions: Cerebral Infarction
Interventions: DRUG: Amantadin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Palbociclib With Everolimus + Exemestane In BC
Status: COMPLETED
Conditions: Human Epidermal Growth Factor 2 Negative Carcinoma of Breast|Hormone Receptor (HR)-Positive Breast Cancer
Interventions: DRUG: Palbociclib|DRUG: Everolimus|DRUG: Exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Copenhagen Arterial Revascularization Randomized Patency and Outcome Trial
Status: UNKNOWN
Conditions: Coronary Arteriosclerosis|Ischemic Heart Disease|Angina Pectoris
Interventions: PROCEDURE: Total arterial revascularization|PROCEDURE: Conventional revascularization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PD L 506 for Stereotactic Interstitial Photodynamic Therapy of Newly Diagnosed Supratentorial IDH Wild-type Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: 5-aminolevulinic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subcutaneous Progesterone Versus Vaginal Progesterone Tablets for Luteal Phase Support in In Vitro Fertilization (IVF)
Status: COMPLETED
Conditions: In Vitro Fertilization
Interventions: DRUG: Progesterone|DRUG: Progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Safety, Pharmacokinetics and Bioavailability Study Comparing Rate and Extent of Absorption of Two Different Forms of Tafamidis (PF-6291826)
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Tafamidis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intravenous Versus Subcutaneous Amifostine in Prevention of Xerostomia After RT for Head and Neck Carcinomas
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: Ethyol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of an Ophthalmic Solution in Patients With Age-Related Cataract
Status: UNKNOWN
Conditions: Cataract
Interventions: DRUG: C-KAD Ophthalmic Solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study of an Ocular Sirolimus (Rapamycin) Formulation in Patients With Age-Related Macular Degeneration
Status: TERMINATED
Conditions: Age-related Macular Degeneration|Choroidal Neovascularization
Interventions: DRUG: Sirolimus|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brief-intensive CBT Versus Once-weekly CBT in Anxiety-related Disorders
Status: NOT_YET_RECRUITING
Conditions: Anxiety Disorders|Obsessive-Compulsive Disorder|Posttraumatic Stress Disorder|Hypochondriasis
Interventions: BEHAVIORAL: Cognitive behavioral therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sequencing of Sipuleucel-T and ADT in Men With Non-metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasm|Prostate Cancer|Prostatic Adenocarcinoma
Interventions: BIOLOGICAL: sipuleucel-T|DRUG: leuprolide acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of an Anti-PD1 Antibody With Tisagenlecleucel Reinfusion in Children, Adolescents and Young Adults With Acute Lymphoblastic Leukemia After Loss of Persistence
Status: RECRUITING
Conditions: B Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia, in Relapse
Interventions: DRUG: Decreasing starting times for beginning nivolumab (Time to Event Continual Reassessment Method (TITE-CRM) )|DRUG: Nivolumab starting at day -1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ability of Aridol to Detect Bronchial Hyperresponsiveness in Suspected Asthmatics
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Aridol|DRUG: Methacholine|PROCEDURE: Exercise challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Self-Administered Relaxing Acupressure to Reduce Fatigue in Adolescent and Young Adult Cancer Survivors
Status: NOT_YET_RECRUITING
Conditions: Hematopoietic and Lymphatic System Neoplasm|Malignant Solid Neoplasm
Interventions: PROCEDURE: Acupressure Therapy|PROCEDURE: Acupressure Therapy|OTHER: Internet-Based Intervention|OTHER: Interview|OTHER: Medical Device Usage and Evaluation|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Orally Administered ENT-01 for Parkinson's Disease-Related Constipation (KARMET)
Status: COMPLETED
Conditions: Constipation|Parkinson Disease
Interventions: DRUG: Active Investigational Treatment ENT-01|DRUG: Placebo Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's Disease or Lewy Body Dementia (Cognition, Memory, Attention, Thinking)
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild Cognitive Impairment|Mild Dementia|Parkinson Disease|Lewy Body Disease
Interventions: DRUG: Placebo Oral Capsule|DRUG: NYX-458
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post Market Study Evaluating Princess Filler Lidocaine for the Correction of Nasolabial Folds
Status: COMPLETED
Conditions: Correction of Nasolabial Folds
Interventions: DEVICE: Princess FILLER Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Investigation of Prostate Artery Embolization Compared to Holmium Laser Enucleation of Prostate
Status: ACTIVE_NOT_RECRUITING
Conditions: Benign Prostatic Hyperplasia
Interventions: DEVICE: Embosphere Microspheres|PROCEDURE: HoLEP Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Acute Effects of Caloric Restriction on Anthropometrics, Metabolism, and Cardiovascular Health in Overweight Adults
Status: COMPLETED
Conditions: Obesity|Overweight|Intermittent Fasting
Interventions: DIETARY_SUPPLEMENT: 3 day caloric restriction/metabolic reset
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Splinted or Non-splinted Single-unit Crowns on Marginal Bone-level Alterations Around Implants
Status: RECRUITING
Conditions: Jaw, Edentulous, Partially
Interventions: PROCEDURE: prothetic procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine as a Rapid Bolus in Children for Emergence Agitation
Status: COMPLETED
Conditions: Tonsillectomy
Interventions: DRUG: Dexmedetomidine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Subjects With Advanced HCC Who Have Not Received Previous Systemic Anticancer Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Cabozantinib|DRUG: Cabozantinib|DRUG: Sorafenib|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Patient Selection for Pancreatic Resections
Status: COMPLETED
Conditions: Pancreas Disease
Interventions: OTHER: Persons with pancreatic resection in a hospital with at least 50 pancreatic resections annually (observational),|OTHER: Persons with pancreatic resection in a hospital not performing at least 50 pancreatic resections annually (observational),
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Digital-based Psychosocial Intervention for Parents of Children With Neurodevelopmental Disorders
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism Spectrum Disorder|Attention Deficit Hyper Activity
Interventions: BEHAVIORAL: Digital Psychosocial intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics for the Treatment of Irritable Bowel Syndrome in Celiac Patients
Status: UNKNOWN
Conditions: IBS in Celiac Desease
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radicle Recharge: A Study of Health and Wellness Products on Energy Levels and Other Health Outcomes
Status: COMPLETED
Conditions: Energy|Fatigue
Interventions: DIETARY_SUPPLEMENT: Recharge Placebo Control 1|DIETARY_SUPPLEMENT: Recharge Active Study Product 1|DIETARY_SUPPLEMENT: Recharge Active Study Product 2|DIETARY_SUPPLEMENT: Recharge Active Study Product 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Ultrasonographic Versus Renographic Parameters in Prediction of Early Success After Pyeloplasty in Children
Status: UNKNOWN
Conditions: Pyeloplasty|Pediatrics|Renogram|Ultrasonography
Interventions: DIAGNOSTIC_TEST: Ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Integrated Multidisciplinary Care for Parkinson's Disease: a Controlled Trial
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: OTHER: Multidisciplinary Care|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Benign Prostate Surgery and QOL and Sexual Function
Status: RECRUITING
Conditions: Quality of Life|Sexual Dysfunction|Ejaculatory Dysfunction|Lower Urinary Tract Symptoms|Erectile Dysfunction|Incontinence
Interventions: PROCEDURE: Monopolar / Bipolar Transurethral resection of prostate (TURP), photovaporisation (PVP), Plasmakinetic (PK), Holmium laser enucleation of the prostate (HOLEP) or open prostatectomy (OP)).
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of SODB® in Metabolic Adaptations in Overweight Women
Status: UNKNOWN
Conditions: Overweight
Interventions: DIETARY_SUPPLEMENT: SODB Dimpless|DIETARY_SUPPLEMENT: Placebo|OTHER: caloric restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ultrasound-guided FICB for Proximal Femoral Osteotomy in Pediatric Patients
Status: RECRUITING
Conditions: Orthopedic Disorder
Interventions: PROCEDURE: Ultrasound-guided fascia iliaca compartment block|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of Pencil Beam Scanning Proton Therapy for Previously Irradiated Tumors
Status: RECRUITING
Conditions: CNS Cancer|Head and Neck Cancer|GI Cancer|Gynecologic Cancer|Prostate Cancer|Thoracic Cancer|Breast Cancer
Interventions: RADIATION: Pencil Beam Scanning Proton Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Medical Practice in the Management of Bone Metastases After Injectable Bone Antiresorptive Treatment, and Its Influence on Quality of Life
Status: RECRUITING
Conditions: Tumor With Bone Metastasis
Interventions: OTHER: quality of life questionaries|DRUG: intravenous or oral bone antiresorptive treatments
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Pilot Study to Assess the Efficacy and Safety of Folic Acid and/or Vitamin B Complex on Hepatitis C Infected Patients Treated With Pegylated Interferon and Ribavirin.
Status: UNKNOWN
Conditions: Hepatitis C
Interventions: DIETARY_SUPPLEMENT: Folic acid|DRUG: Neurobion|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of CPAP and Adenotonsillectomy in Upper Airway Volume of Children With OSAS
Status: UNKNOWN
Conditions: Sleep Apnea, Obstructive|Child|Continuous Positive Airway Pressure|Adenoidectomy|Tonsillectomy
Interventions: DEVICE: Continuous positive airway pressure (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate Tolerability and Efficacy of Asciminib (Oral) Versus Nilotinib (Oral) in Adult Participants (≥18 Years of Age) With Newly Diagnosed Philadelphia Chromosome Positive Chronic Myelogenous Leukemia in Chronic Phase (Ph+ CML-CP)
Status: RECRUITING
Conditions: Philadelphia Chromosome-Positive Chronic Myeloid Leukemia
Interventions: DRUG: Asciminib|DRUG: Nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Very Early veRsus Deferred Invasive Evaluation Using Computerized Tomography in Patients With Acute Coronary Syndromes
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Invasive coronary evaluation (Deferred)|PROCEDURE: Invasive coronary evaluation (Acute)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RF-EMF Effects on the CNS in Elderly Men
Status: COMPLETED
Conditions: Non-Ionizing Radiation
Interventions: RADIATION: Exposure with non-ionizing electromagnetic fields
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Protein and Resistance Training on Muscle Mass in Acutely Ill Old Medical Patients
Status: COMPLETED
Conditions: Systemic Inflammatory Response Syndrome
Interventions: OTHER: High-protein diet and resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study of TUTI-16 in Asymptomatic HIV-1 Infected Subjects (THYMON-11001)
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: TUTI-16 (1.0 mg)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Erector Spinae Plane Blocks
Status: COMPLETED
Conditions: Rib Fractures
Interventions: PROCEDURE: EPSB for rib fractures|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study of Sanjin Tablets for the Treatment of Acute Simple Lower Urinary Tract Infection
Status: UNKNOWN
Conditions: Urinary Tract Infection Lower Acute
Interventions: DRUG: Sanjin tablets|DRUG: Sanjin tablets simulants|DRUG: Levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of Epoetin Alfa in Patients With Cancer Who Have Chemotherapy-Related Anemia
Status: COMPLETED
Conditions: Anemia|Neoplasms
Interventions: DRUG: Epoetin alfa 450 IU/kg once a week|DRUG: Epoetin alfa 150 IU/kg 3 times a week|DRUG: Epoetin alfa 450 IU/kg once a week (QW)|DRUG: Epoetin alfa 150 IU/kg 3 times a week (TIW)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vanguard Rocc Post Market Surveillance
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis, Knee|Rheumatoid Arthritis|Traumatic Arthritis|Posttraumatic Deformity|Varus Deformity|Valgus Deformity|Osteotomy|Arthrodesis
Interventions: PROCEDURE: Vanguard Rocc
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of HGI (Hemoglobin Glycation Index) Variability Over Time in Patients Living With Diabetes Using Continuous Glucose Monitoring ( GAP OUEST )
Status: RECRUITING
Conditions: Diabetes Mellitus
Interventions: OTHER: HGI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Tobramycin Inhalation Solution for Pseudomonas Aeruginosa Eradication in Bronchiectasis
Status: RECRUITING
Conditions: Bronchiectasis Adult|Pseudomonas Aeruginosa Infection
Interventions: DRUG: Tobramycin Inhalant Product|DRUG: Ciprofloxacin 750 MG|DRUG: Oral ciprofloxacin placebo|DRUG: Natural saline inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Assessing the Safety and Pharmacokinetic Profile of Modified Release Formulations of Tolcapone
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Tolcapone|DRUG: Tolcapone Modified Release Prototype|DRUG: Tolcapone Divided Dose|DRUG: Tolcapone Modified Release Prototype
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study Comparing Immunogenicity, Reactogenicity and Safety of GSK Bios' HBV-MPL Vaccine With That of Engerix™-B in Adults
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: HBV-MPL vaccine|BIOLOGICAL: Engerix™-B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial on the Efficacy of a Combination Herbal Product, Biotropics' Nu Femme, on Menopausal Symptoms and Quality of Life in Women
Status: COMPLETED
Conditions: Menopausal Symptoms
Interventions: DIETARY_SUPPLEMENT: Nu Femme|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: FARE Peanut SLIT and Early Tolerance Induction
Status: COMPLETED
Conditions: Peanut Hypersensitivity|Food Allergy|Food Hypersensitivity|Peanut Allergy
Interventions: DRUG: Liquid Peanut Extract|DRUG: Placebo Glycerin SLIT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic, Safety and Efficacy Study of Nanoparticle Paclitaxel in Patients With Peritoneal Cancers
Status: COMPLETED
Conditions: Peritoneal Neoplasms
Interventions: DRUG: nanoparticulate paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms
Status: TERMINATED
Conditions: COVID|Corona Virus Infection|Respiratory Failure|Respiratory Distress Syndrome, Adult|ARDS, Human|SARS (Severe Acute Respiratory Syndrome)
Interventions: DEVICE: gammaCore® Sapphire (non-invasive vagus nerve stimulator)|OTHER: Standard of care therapies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of 8 Weeks of Functional and Traditional Resistance Training on Range-of-motion, Dynamic Balance, Technical Skills, Change of Directions, Linear Sprint, and Jump Performance in U-16 Norwegian Young Sub-elite Soccer Players
Status: ACTIVE_NOT_RECRUITING
Conditions: Injury;Sports
Interventions: OTHER: Experimental, comparator and control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cross Education for Upper Extremity Motor Function and Strength in Stroke
Status: ENROLLING_BY_INVITATION
Conditions: Stroke
Interventions: OTHER: Physiotherapy Training (PT)|DEVICE: Cross-Education Intervention|OTHER: Control Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: New Approach for Treatment of Behavioral Disorders in Alzheimer's Disease (Alzheimer's Behavioral and Cognitive Disorders)
Status: COMPLETED
Conditions: Alzheimer Disease|Behavioral Disorders|Cognitive Impairment
Interventions: OTHER: Ecological Environmental therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Biologic Activity Study of Gevokizumab to Treat Erosive Osteoarthritis of the Hand
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Placebo|DRUG: gevokizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Switching From Cardiac Troponin I to T
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Acute Myocardial Infarction|Acute Myocardial Ischemia|Myocardial Injury|Chest Pain|Heart Failure
Interventions: DIAGNOSTIC_TEST: Clinical implementation of hs-cTnT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Three-Dimensional Fluoroscopic Guidance During Transbronchial Cryobiopsy
Status: COMPLETED
Conditions: Lung Carcinoma
Interventions: OTHER: Electronic Health Record Review|PROCEDURE: Transbronchial Cryobiopsy Guided by Three-Dimensional Fluoroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Acalabrutinib and High Frequency Low Dose Subcutaneous Rituximab in Patients With Previously Untreated Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia (CLL)|Small Lymphocytic Lymphoma (SLL)
Interventions: DRUG: Acalabrutinib|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of UV-4B Solution Administered Orally as Multiple Ascending Doses to Healthy Subjects
Status: TERMINATED
Conditions: Viral Infection
Interventions: DRUG: UV-4B 30 mg oral solution|DRUG: UV-4B 75 mg oral solution|DRUG: UV-4B 150 mg oral solution|DRUG: UV-4B X mg (dose to be determined) oral solution|DRUG: UV-4B Y mg (dose to be determined) oral solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Food FARMacia: Reducing Childhood Obesity in Households With Food Insecurity
Status: RECRUITING
Conditions: Nutrition, Healthy
Interventions: BEHAVIORAL: Food FARMacia Program|BEHAVIORAL: Self-directed meal preparation support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Physical Therapy Versus Steroid Injection for Shoulder Impingement Syndrome
Status: COMPLETED
Conditions: Shoulder Impingement Syndrome
Interventions: PROCEDURE: Manual Physical Therapy|PROCEDURE: Corticosteroid Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: the Effect of the Transversus Abdominis Plane (TAP) Block on the Minimal Laparotomy : a Randomized Controlled Trial
Status: UNKNOWN
Conditions: Colon Cancer
Interventions: PROCEDURE: Transversus Abdominis Plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Differential Effect of Silodosin Versus Tamsulosin on Stone Clearance After Extra-corporeal Shock Wave Lithotripsy
Status: WITHDRAWN
Conditions: Kidney Stones
Interventions: DRUG: silodosin|PROCEDURE: Extra-corporeal shock wave lithotripsy|DRUG: Tamsulosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Near-infrared Zone II Imaging in Sentinel Lymph Node Mapping in Breast Cancer Patients
Status: UNKNOWN
Conditions: Breast Cancer|Sentinel Lymph Node
Interventions: PROCEDURE: Near infrared fluorescence navigated sentinel lymph node mapping
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PRObiotic and Stress-related PERmeability
Status: COMPLETED
Conditions: Permeability; Increased
Interventions: DIETARY_SUPPLEMENT: Fresh fermented dairy drink containing probiotic strain|OTHER: Acidified dairy drink without ferment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Different Doses of SY-004 in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: SY-004|OTHER: SY-004 matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Palmitoylethanolamide for Post-operative Pain Prevention
Status: UNKNOWN
Conditions: Chronic Post-operative Pain
Interventions: DIETARY_SUPPLEMENT: Palmitoylethanolamide|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Determination of Changes in Total Body Stores of Vitamin A in Response to Orange Maize Consumption by Zambian Children
Status: COMPLETED
Conditions: Vitamin A Status With Maize Feeding
Interventions: OTHER: Orange maize feeding|OTHER: Vitamin A supplement|OTHER: Oil only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Investigate the Effect of Urine Acid-base Disequilibrium on the Pharmacokinetics of Captopril
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Captopril 12.5 Mg|DRUG: Sodium bicarbonate 4 G|DRUG: Torsemide 20 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Proton Pump Inhibitor (PPI, Rabeprazole) Effect On Tablet Formulation Of Palbociclib
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Palbociclib|DRUG: Rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Brain Stimulation During Nocturnal Sleep on Memory Consolidation in Patients With Mild Cognitive Impairments
Status: WITHDRAWN
Conditions: Mild Cognitive Impairment, So Stated
Interventions: DEVICE: Stimulation|DEVICE: SHAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extract of Ginkgo Biloba (EGB 761) and Vascular Function
Status: COMPLETED
Conditions: Intermittent Claudication|Peripheral Vascular Disease
Interventions: DRUG: Gingko Biloba (Herb)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT