pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of White Potato Consumption on Measures of Cardiometabolic Health in Individuals With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type2 Diabetes|Cardiometabolic Syndrome|Arterial Stiffness|Overweight and Obesity
Interventions: OTHER: Potato Regimen|OTHER: Refined Grain Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Results of Retrograde Titanium Elastic Nails for Fixation of Proximal Third Tibial Shaft Fractures in Children.
Status: RECRUITING
Conditions: Proximal Third Tibial Shaft Fractures in Children
Interventions: PROCEDURE: retrograde titanium elastic nails for fixation of proximal third tibial shaft fractures in children
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Comparison of Two Daily Disposable Contact Lenses - Pilot Study 3
Status: COMPLETED
Conditions: Myopia|Ametropia
Interventions: DEVICE: Verofilcon A contact lenses|DEVICE: Kalifilcon A contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Development and Evaluation of an Exercise Intervention for Prevention of Vertebral Osteoporosis and Deformity in Postmenopausal Women
Status: COMPLETED
Conditions: Osteoporosis|Osteoporotic Fracture of Vertebra|Postural, Thoracic Kyphosis
Interventions: OTHER: A resistance band exercise programme|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Posture and Passive Cycling on Cardiac Autonomic Control System in Children With Severe Cerebral Palsy
Status: UNKNOWN
Conditions: Cerebral Palsy
Interventions: DEVICE: Innowalk cycling system|DEVICE: APT cycling system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Stryker Triathlon® Cruciate Substituting vs. Posterior Stabilized Outcomes Study
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Stryker Triathlon® CS Tibial Insert|DEVICE: Stryker Triathlon® PS Tibial Insert
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Liposomal Lidocaine on Perceived Pain in Children During Percutaneous Interosseous Pin Removal in the Outpatient Setting
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Liposomal Lidocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Total Knee Arthroplasty Analgesia: Single-shot Femoral Nerve Block or Epidural?
Status: COMPLETED
Conditions: Postoperative Pain Treatment for Total Knee Arthroplasty
Interventions: DRUG: Ropivacaine perineural injection|DRUG: morphine and ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Safety, Tolerability and Efficacy of RZ-001 With Valganciclovir (VGCV) in Subjects With Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: RZ-001|COMBINATION_PRODUCT: VGCV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Part A: Radiolabel Study With GW786034 Part B: Single Dose of GW786034
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: GW786034, oral|DRUG: GW786034, IV|DRUG: GW786034, radiolabeled oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraocular Pressure Versus Optic Nerve Sheath Diameter
Status: UNKNOWN
Conditions: Intraocular Pressure|Optic Nerve Sheath Diameter
Interventions: PROCEDURE: Schiotz tonometer for Intraocular Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Biparental HLA Haplotype Disparate T-cell Depleted Transplants for Patients Lacking an HLACompatible Donor
Status: TERMINATED
Conditions: Acute Leukemia|Chronic Leukemia|Myelodysplastic Syndrome|Non-Hodgkins Lymphoma
Interventions: RADIATION: total-body irradiation (TBI)|DRUG: thiotepa|DRUG: fludarabine phosphate|DRUG: melphalan|BIOLOGICAL: anti-thymocyte globulin|PROCEDURE: allogeneic hematopoietic stem cell transplantation|BIOLOGICAL: peripheral blood stem cell transplantation|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect and Associated Factors of the Clinical Pharmacy Model in the Incidence of Medical Errors
Status: COMPLETED
Conditions: Pharmaceutical Services|Medication Errors|Drug-Related Side Effects and Adverse Reactions|Outcome Assessment (Health Care)
Interventions: OTHER: Clinical pharmacy model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Assessment of the Effect of Sertaline on the Specific Binding of 123-I MZINT in Healthy Subjects
Status: TERMINATED
Conditions: Depression
Interventions: DRUG: 123-I MZINT injection and SPECT imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Topical Moxifloxacin for Prevention of Post-Traumatic Endophthalmitis: Randomized Controlled Clinical Trial
Status: UNKNOWN
Conditions: Endophthalmitis|Open Globe Injury|Moxifloxacin|Post-Traumatic Endophthalmitis
Interventions: DRUG: Moxifloxacin Ophthalmic 0.5% Ophthalmic Solution|DRUG: Ciprofloxacin 400 MG/200 ML Intravenous Solution [CIPRO IV]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Improving Physical Activity and Gait Symmetry After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Replacement, Total|Knee Arthroplasty, Total
Interventions: BEHAVIORAL: PAS Intervention|BEHAVIORAL: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spa Rehabilitation, Antioxidant and Bioenergetic Supportive Treatment of Patients With Post-Covid-19 Syndrome
Status: COMPLETED
Conditions: COVID-19 Respiratory Infection
Interventions: DIETARY_SUPPLEMENT: ubiquinol (reduced coenzyme Q10)|OTHER: mountain spa rehabilitation|DIAGNOSTIC_TEST: 2x14 ml of peripheral blood collected in a tube with anticoagulant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Assess Clinical Response of Duloxetine in Patients Hospitalized for Severe Depression
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Duloxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NEUROFEEDBACK TRAINING FOR OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT: A PILOT STUDY
Status: UNKNOWN
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prevention of Ocular Graft-Versus-Host Disease With Topical Cyclosporine in Recipients of Allogeneic HSCT
Status: COMPLETED
Conditions: Graft-Versus-Host Disease
Interventions: DRUG: Cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Performance, Safety, and Efficacy of a New Cyrotherapy Device for Cervical Dysplasia
Status: COMPLETED
Conditions: Cervical Dysplasia
Interventions: DEVICE: CryoPop|DEVICE: MedGyn MGC 200
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Hydroxychloroquine in SARS-CoV-2 (COVID-19) Pneumonia Trial
Status: WITHDRAWN
Conditions: SARS-CoV-2 Pneumonia|COVID-19
Interventions: DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Adding Pilates Exercises to Sports Hernia Rehabilitation:a Comparative Clinical Trial
Status: RECRUITING
Conditions: Pilates Exercises|Sports Hernia
Interventions: OTHER: combination of pilates exercises, Low-level laser therapy, and low-intensity ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fosmidomycin and Azithromycin for Acute Uncomplicated Plasmodium Falciparum Malaria (P. Malaria) in Adults
Status: UNKNOWN
Conditions: Malaria
Interventions: DRUG: Fosmidomycin|DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cetuximab, Oxaliplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Stage II or Stage III Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: fluorouracil|DRUG: oxaliplatin|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Bioequivalence Study on Two Methyldopa Tablet 250mg Formulations
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BF-Methyldopa 250mg Tablet|DRUG: Metopa Tab 250mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Trial to Evaluate the Safety & Efficacy of the Omnilink Elite™ Peripheral Balloon-Expandable Stent System in Subjects With Atherosclerotic de Novo or Restenotic Lesions in the Native Common Iliac Artery and/or Native External Iliac Artery
Status: COMPLETED
Conditions: Peripheral Vascular Disease
Interventions: DEVICE: Omnilink Elite™ Peripheral Balloon-Expandable Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Phase 2 Trial of TAS-114 in Combination With S-1 Versus S-1
Status: COMPLETED
Conditions: Advanced or Metastatic Non-small Cell Lung Cancer
Interventions: DRUG: TAS-114|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studying Complement Inhibition in Complex Cardiac Surgery
Status: COMPLETED
Conditions: Systemic Inflammatory Response Syndrome|C.Surgical Procedure; Cardiac
Interventions: BIOLOGICAL: IFX-1|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Icotinib at Different Doses in Second-line Treatment for Non-small Cell Lung Cancer Patients With Wild Type EGFR
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Icotinib of routine dose|DRUG: Icotinib of high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Onartuzumab (MetMAb) in Combination With Tarceva (Erlotinib) in Participants With Met Diagnostic-Positive Non-Small Cell Lung Cancer Who Have Received Chemotherapy For Advanced or Metastatic Disease (MetLung)
Status: COMPLETED
Conditions: Non-Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: Erlotinib|DRUG: Onartuzumab (MetMab)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of ASC40 in Subjects With Moderate to Severe Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: ASC40 25mg|DRUG: ASC40 50mg|DRUG: ASC40 75mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outpatient Pulmonary Rehabilitation in Non-small-cell Lung Cancer Receiving Immunotherapy
Status: NOT_YET_RECRUITING
Conditions: NSCLC Stage IV
Interventions: OTHER: outpatient pulmonary rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BEHAVIORAL: Dyspnea Intervention|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 'SPRING'-Study: "Subfertility Guidelines: Patient Related Implementation in the Netherlands Among Gynaecologists"
Status: UNKNOWN
Conditions: Male Infertility|Female Infertility|Ovarian Hyperstimulation Syndrome|Premature Ovarian Failure|Endometriosis
Interventions: BEHAVIORAL: patient education|BEHAVIORAL: professional audit and feedback (guideline adherence)|BEHAVIORAL: professional education (communication/shared decision making)|OTHER: information tools
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose:
Clinical trial: Efficacy and Safety of Riociguat in Patients With Symptomatic Pulmonary Hypertension (PH) Associated With Idiopathic Interstitial Pneumonias (IIP)
Status: TERMINATED
Conditions: Idiopathic Interstitial Pneumonias / Hypertension,Pulmonary
Interventions: DRUG: Riociguat (Adempas, BAY63-2521)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: REACH: Study to Determine the Aetiology of Chlormethine Gel Induced-skin Drug Reaction in Early Stage Mycosis Fungoides Cutaneous T Cell Lymphoma (MF-CTCL)
Status: TERMINATED
Conditions: Early Stage Mycosis Fungoides Cutaneous T Cell Lymphoma (MF-CTCL) (Stage IA-IB)
Interventions: DRUG: chlormethine gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prognosis Related to Induced Thrombopenia With Heparin Under Venoarterial ECMO in Reanimation
Status: COMPLETED
Conditions: Heparin-induced Thrombocytopenia
Interventions: OTHER: Hospitalization for more than 3 days with high clinical suspicion of HIT and positive anti-PF4/heparin antibodies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 3 Study to Evaluate the Safety and Efficacy of Efgartigimod PH20 Subcutaneous in Adult Patients With Primary Immune Thrombocytopenia
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Immune Thrombocytopenia
Interventions: BIOLOGICAL: efgartigimod PH20 SC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Post Dural Pucture Headache After Lower Limb Surgeries: Oral Prednisolone vs Oral Pregabalin
Status: COMPLETED
Conditions: Analgesia
Interventions: DRUG: caffeine, paracetamol tablet|DRUG: Oral prednisolone|DRUG: oral pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Antibody Persistence in Children Previously Vaccinated With Infanrix Hexa™ or Infanrix-IPV/Hib™
Status: COMPLETED
Conditions: Tetanus|Poliomyelitis|Haemophilus Influenzae Type b|Acellular Pertussis|Diphtheria|Hepatitis B|Diphtheria-Tetanus-aPertussis-Poliomyelitis-Haemophilus Influenzae Type b Vaccines
Interventions: PROCEDURE: Blood Sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of CPAP Level on V/Q Mismatch in Premature Infants
Status: COMPLETED
Conditions: Infant, Premature, Diseases|Respiratory Insufficiency Syndrome of Newborn
Interventions: DEVICE: Continuous positive airway pressure (CPAP); level changes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Whether the Bispectral Index Prevents Patients at Higher Risk From Being Awake During Surgery and Anesthesia
Status: COMPLETED
Conditions: Explicit Recall of Intra-Operative Events
Interventions: BEHAVIORAL: Bispectral index protocol|BEHAVIORAL: End tidal anesthetic gas-guided
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical and Radiological Results of Long Term Tibial and Femoral Osteotomy in Knee Ostheoarthritis With Concomitant Lower Limb Malalignement
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee Osteoarthritis|Malalignment, Bone
Interventions: OTHER: High tibial osteotomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of PET With 68GA-PSMA-11 and 18F-Fluorocholine for Recurrence in Men With Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DRUG: 68Ga-PSMA-11 PET|DRUG: 18F-FCH PET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Horizontal Bone Gain in the Lower Posterior Partially Edentulous Patient Comparing the Stabilization of Membranes With and Without Tacs
Status: NOT_YET_RECRUITING
Conditions: Guided Bone Regeneration
Interventions: PROCEDURE: Guided Bone regeneration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindful Moms: Mechanisms of Mindfulness-based Cognitive Therapy During Pregnancy and Postpartum
Status: RECRUITING
Conditions: Psychological Distress|Pregnancy Related|Postpartum Blues|Postpartum Depression|Postpartum Anxiety|Postpartum Sadness
Interventions: BEHAVIORAL: Mindfulness-Based Cognitive Therapy (MBCT)|BEHAVIORAL: Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2b Study of Dalfampridine 10mg Extended Release Tablet in Subjects With Chronic Deficits After Ischemic Stroke
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: placebo/dalfampridine-ER|DRUG: dalfampridine-ER/placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Rapid Acclimatization to Hypoxia at Altitude
Status: COMPLETED
Conditions: Physiological Function in Low Oxygen Environment
Interventions: DRUG: Placebo|DRUG: Aminophylline|DRUG: Methazolamide|DRUG: Aminophylline+Methazolamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Mesenchymal Stem Cell Therapy for Knee Osteoarthritis
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: BIOLOGICAL: Bone Marrow Derived MSCs|DRUG: Corticosteroid|DEVICE: Bone Marrow Aspirate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study the Result of Ayurvedic SUVED & Reimmugen (Colostrum) Treatment on Vascular Disease, CAD, CVA, DVT.
Status: COMPLETED
Conditions: Coronary Artery Disease|Cerebro Vascular Disease|Ischemic Heart Disease|Deep Vein Thrombosis|Peripheral Arterial Diseases|Vascular Disease
Interventions: DRUG: SUVED|COMBINATION_PRODUCT: REIMMUGEN|OTHER: Grain flour placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aldosterone and Vascular Disease in Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus|Endothelial Dysfunction|Albuminuria
Interventions: DRUG: eplerenone|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Long-term Follow-up Study of Patients Receiving Onasemnogene Abeparvovec-xioi
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Muscular Atrophy Type I|Spinal Muscular Atrophy Type II|Spinal Muscular Atrophy Type III|SMA
Interventions: BIOLOGICAL: Onasemnogene Abeparvovec-xioi
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritional Intervention to Enhance Recovery After Arthroscopic Knee Surgery in Adults
Status: RECRUITING
Conditions: Anterior Cruciate Ligament Reconstruction|Muscular Atrophy
Interventions: DIETARY_SUPPLEMENT: Omega-3 Fatty Acids and Essential Amino Acids|DIETARY_SUPPLEMENT: Safflower Oil and Non-Essential Amino Acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long-acting Paliperidone Palmitate Injection and Olanzapine for Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Olanzapine|DRUG: Paliperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Controlled Ovarian Stimulation Versus Modified Natural Cycles in Poor Responders
Status: RECRUITING
Conditions: Ovarian Reserve|Poor Responders|IVF
Interventions: DRUG: A single Gonadotropin-Releasing Hormone (GnRH) antagonist corifollitropin alfa (CFA) stimulation|DRUG: Up to three modified natural cycles with Follitropin beta.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Function at Presentation and Follow-up in Hemato-Oncology 3-7 Years Old Children
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Acute Myeloblastic Leukemia|Solid Tumors,|Hodgkin's Disease|Non-Malignant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Onalespib, Dabrafenib, and Trametinib in Treating Patients With BRAF-Mutant Melanoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery
Status: UNKNOWN
Conditions: BRAF V600E Mutation Present|BRAF V600K Mutation Present|Metastatic Malignant Solid Neoplasm|Metastatic Melanoma|Stage III Cutaneous Melanoma AJCC v7|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7|Unresectable Solid Neoplasm
Interventions: DRUG: Dabrafenib|OTHER: Laboratory Biomarker Analysis|DRUG: Onalespib|OTHER: Pharmacological Study|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Object Assessment of Improvement in Non-Specific Symptoms After Parathyroidectomy for Primary Hyperparathyroidism
Status: COMPLETED
Conditions: Primary Hyperparathyroidism|Multinodular Goiter
Interventions: BEHAVIORAL: Activity Tracker (Fitbit)|DIAGNOSTIC_TEST: HbA1C|BEHAVIORAL: The PROMPT Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study to Evaluate Utility of EnteroTracker® as a Minimally Invasive Sampling Method to Screen for Barrett's Esophagus and Esophageal Cancer
Status: NOT_YET_RECRUITING
Conditions: Barrett Esophagus|Esophageal Cancer
Interventions: DEVICE: EnteroTracker
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy Study of Nitazoxanide Suspension in the Treatment of Rotavirus Disease in Children
Status: COMPLETED
Conditions: Rotavirus Infection|Viral Gastroenteritis Due to Rotavirus
Interventions: DRUG: Nitazoxanide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-response Study to Evaluate Safety, Efficacy, and Pharmacokinetics of PF-00217830 Compared With Placebo in Acute Exacerbation of Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: PF-00217830|OTHER: Placebo|DRUG: Aripiprazole|DRUG: PF-00217830|DRUG: PF-00217830
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Combined Medication Treatment for Aggression in Children With Attention Deficit With Hyperactivity Disorder (The SPICY Study)
Status: UNKNOWN
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: Valproate|DRUG: Risperidone|DRUG: Placebo|DRUG: Stimulant medication|BEHAVIORAL: Behavioral family counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guidance Vs. Electrical Nerve Stimulation for Infraclavicular Brachial Plexus Block
Status: COMPLETED
Conditions: Hand Surgery|Brachial Plexus Block
Interventions: PROCEDURE: brachial plexus block|PROCEDURE: ultrasound guidance|PROCEDURE: electrical nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose:
Clinical trial: Capability of Tofacitinib or Etanercept to Accelerate Tapering of NSAID and Treat-to-target Guided De-escalation of Corticosteroids in RA Patients
Status: COMPLETED
Conditions: Rheumatic Arthritis
Interventions: DRUG: Tofacitinib|BIOLOGICAL: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Application of Silver Nanoparticles and Oral Pathogens in Ill Patients
Status: COMPLETED
Conditions: Critical Illness
Interventions: OTHER: silver nanoparticles|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Oral Moisturizing Jelly on Oral Health and Nutrition in Post-radiotherapy Head and Neck Cancer Patients
Status: COMPLETED
Conditions: Cancer of Head Neck|Radiation-Induced Xerostomia|Dry Mouth
Interventions: DIETARY_SUPPLEMENT: Oral moisturizing jelly|OTHER: Artificial saliva
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetic Profile of Voriconazole Inhalation Powder in Adult Subjects With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Voriconazole Inhalation Powder|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Frenotomy and Frenectomy Techniques for Management of High Frenum Attachment in Adults
Status: RECRUITING
Conditions: High Frenum Attachment
Interventions: PROCEDURE: Frenotomy|PROCEDURE: Frenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Subcuticular Skin Closure Versus Steri-strip S Closure
Status: COMPLETED
Conditions: Breast Hypertrophy|Abdominal Elastosis|Breast Reconstruction
Interventions: DEVICE: wound closure device (Steri-Strip™)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of the Immune Response and the Safety of a Pandemic Influenza Candidate Vaccine (H1N1)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Pandemrix (GSK investigational influenza GSK2340272A vaccine)|BIOLOGICAL: Fluarix™|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of the Effects of Ciclesonide Hydrofluoroalkane (HFA) Nasal Aerosol on Hypothalamic-Pituitary-Adrenal (HPA) Axis
Status: COMPLETED
Conditions: Perennial Allergic Rhinitis
Interventions: DRUG: Ciclesonide HFA Nasal Aerosol 320 mcg|DRUG: Ciclesonide HFA Nasal Aerosol 160 mcg|DRUG: HFA Nasal Aerosol placebo|DRUG: Ciclesonide Aqueous Nasal Spray 200 mcg|DRUG: AQ Nasal Spray Placebo|DRUG: Placebo plus Dexamethasone HFA|DRUG: Placebo AQ plus Dexamethasone 6 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Aim of This Study is to Determine the Effectiveness of a Motivational Enhancement Intervention in Reducing Risk Behaviors (Drug and Alcohol Use, Sexual Risk Behavior, Poor Adherence to Medications) Among HIV+ Youth. - 1
Status: UNKNOWN
Conditions: Adherence|HIV Risk Behaviors|Alcohol & Drug Use|Health Behaviors|Sexual Risk Behaviors
Interventions: BEHAVIORAL: Motivational interviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine With or Without Capecitabine and/or Radiation Therapy or Gemcitabine With or Without Erlotinib in Treating Patients With Locally Advanced Pancreatic Cancer That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: capecitabine|DRUG: erlotinib hydrochloride|DRUG: gemcitabine hydrochloride|OTHER: laboratory biomarker analysis|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Interventional Study of Avastin (Bevacizumab) in Patients With Advanced/Metastatic Epithelial Ovarian Cancer, Fallopian Tube Cancer or Primary Peritoneal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Neoplasms|Peritoneal Neoplasms|Fallopian Tube Neoplasms
Interventions: DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transthoracic Ultrasound in the Diagnosis and Follow-up of Ventilator Associated Pneumonia
Status: UNKNOWN
Conditions: Ventilator Associated Pneumonia|Lung Ultrasound
Interventions: DEVICE: transthoracic ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Radiofrequency and Ultrasound for Improvement of Skin Laxity and Wrinkles: Efficacy and Safety Evaluation
Status: COMPLETED
Conditions: Skin Laxity
Interventions: DEVICE: BTL-585-2 RF+US|DEVICE: BTL-585-2 RF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Synchronous vs Asynchronous Remotely Delivered Lifestyle Interventions
Status: NOT_YET_RECRUITING
Conditions: Obesity
Interventions: BEHAVIORAL: Asynchronous Remote Lifestyle Intervention|BEHAVIORAL: Synchronous Remote Lifestyle Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety of AK111 in Subjects With Moderate to Severe Plaque Psoriasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Psoriasis|Skin Diseases
Interventions: DRUG: AK111|DRUG: AK111|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Palliation of Dyspnea With Mouth Piece Ventilation in AECOPD
Status: TERMINATED
Conditions: COPD Exacerbation|Dyspnea
Interventions: DEVICE: Trilogy 100 ® (Philips Respironics)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of DW-MRI Measures : Reproducibility and Repeatability in Pelvic Imaging on MR-Linac With Healthy Volunteers
Status: NOT_YET_RECRUITING
Conditions: Rectum Cancer|Pelvic Cancer
Interventions: DEVICE: Magnetic Resonance Imaging (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Revaccination With Influenza Vaccine GSK1247446A
Status: COMPLETED
Conditions: Influenza|Influenza, Human
Interventions: BIOLOGICAL: Influenza Vaccine GSK1247446A|BIOLOGICAL: Fluarix™
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Patients With Relapsed or Primary Refractory Aggressive B- Cell NHL
Status: UNKNOWN
Conditions: Lymphoma, High-Grade
Interventions: DRUG: Bendamustine|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Response of Itraconazole and Terbinafine Therapy in Subjects With Crohn's Disease
Status: TERMINATED
Conditions: Crohn's Disease|Inflammatory Bowel Diseases
Interventions: DRUG: Itraconazole 400 mg/day and terbinafine 500 mg/day administered orally.|DRUG: Itraconazole's matching placebo 400 mg/day and terbinafine's matching placebo 500 mg/day administered orally.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Effects on Transcranial Magnetic Stimulation of Oral Doses of XEN1101
Status: COMPLETED
Conditions: Healthy Male Volunteers
Interventions: DRUG: XPF-008|DRUG: Microcrystalline Cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of a CDSA Strategy to Reduce Antibiotic Prescription in Senegal
Status: UNKNOWN
Conditions: Malaria|Dengue|Influenza -Like Illness|Diarrhea|Pneumonia|Acute Febrile Illness
Interventions: OTHER: Patient clinical management based on the CDSA strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of the TOFScan and the WiTOF During Recovery of Neuromuscular Function
Status: COMPLETED
Conditions: Neuromuscular Residual Curarization
Interventions: DEVICE: WiTOF|DEVICE: TOFscan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Cluster-Randomized Trial of Ultrasound Use to Improve Pregnancy Outcomes in Low Income Country Settings
Status: COMPLETED
Conditions: Pregnancy|Eclampsia|Placenta Previa|Stillbirth|Fetal Growth Restriction
Interventions: DEVICE: Antenatal Ultrasound Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pain During Pars Plana Vitrectomy With Sub-tenon Anesthesia
Status: COMPLETED
Conditions: Retinal Disease|Diabetic Retinopathy|Maculopathy
Interventions: PROCEDURE: Topical lidocaine 2% jelly plus sub-tenon ropivacaine 10% injection|PROCEDURE: Peribulbar injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Lebrikizumab in Participants With Uncontrolled Asthma Who Are on Inhaled Corticosteroids and a Second Controller Medication
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Lebrikizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ACL Repair and Multimodal Analgesia
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: multimodal:acetaminophen, gabapentin, ketamine, bupivacaine|DRUG: placebo pills and injectables
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Observational Study of Early Contact With Palliative Care Unit for Patients Receiving First Line Palliative Chemotherapy With Cancer in Upper Gastrointestinal Canal, or Second Line Palliative Chemotherapy in Patients With Colorectal Cancer - an Open, Randomised Investigator Initiated Trial.
Status: UNKNOWN
Conditions: Tumor in Upper Gastrointestinal Canal or Patients With Colorectal Cancer
Interventions: OTHER: Contact with palliative care unit.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bronchoscopic Laser Ablation of Peripheral Lung Tumors
Status: TERMINATED
Conditions: Lung Carcinoid Tumor|Lung Non-Small Cell Carcinoma|Metastatic Lung Carcinoma|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: PROCEDURE: Cone-Beam Computed Tomography|PROCEDURE: Conventional Surgery|PROCEDURE: Laser Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: SAD and MAD Study With IV and SC Doses of ARGX-117
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: ARGX-117|OTHER: Placebo|BIOLOGICAL: ARGX-117 + rHuPH20|OTHER: placebo + rHuPH20|BIOLOGICAL: ARGX-117 PH20 SC|OTHER: Placebo PH20 SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Prolonged PDE-5 Inhibition on Insulin Signaling in Skeletal Muscle.
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DRUG: Sildenafil citrate|DRUG: Placebo Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: TRAnexamic Acid for Preventing Blood Loss Following a Cesarean Delivery in Women With Placenta pREVIA
Status: RECRUITING
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Tranexamic Acid / Sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Radiation Therapy Plus Temozolomide Combined With Cilengitide or Cetuximab on the 1-year Overall Survival of Patients With Newly Diagnosed MGMT-promoter Unmethylated Glioblastoma
Status: TERMINATED
Conditions: Glioblastoma
Interventions: DRUG: Cetuximab|DRUG: Cilengitide EMD 121974
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of Tyramine in Patients Who Completed the PRESTO Study.
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: rasagiline mesylate|OTHER: tyramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tesetaxel Plus 3 Different PD-(L)1 Inhibitors in Patients With Triple-Negative MBC and Tesetaxel Monotherapy in Patients With HER2-Negative MBC
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Tesetaxel|DRUG: Tesetaxel|DRUG: Tesetaxel|DRUG: Nivolumab|DRUG: Pembrolizumab|DRUG: Atezolizumab|DRUG: Tesetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effect of Central Sensitization Symptom Severity on Steroid Injection Results in Shoulder Pain
Status: RECRUITING
Conditions: Rotator Cuff Lesion|Subacromial Impingement Syndrome|Shoulder Pain|Chronic Pain
Interventions: DIAGNOSTIC_TEST: Range of Motion of Shoulde Joint|DIAGNOSTIC_TEST: Hand Grip Test|DIAGNOSTIC_TEST: Numeric Rating Scale|DIAGNOSTIC_TEST: Pain-Pressure Threshold Measurement With an Algometer|DIAGNOSTIC_TEST: Quick DASH|DIAGNOSTIC_TEST: SF-36|DIAGNOSTIC_TEST: Central Sensitization Scale|DIAGNOSTIC_TEST: Hospital Anxiety and Depression Scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Different Strategies of Pericardial Drainage After Aortic Valvular Surgery
Status: COMPLETED
Conditions: Pericardial Effusion|Late Cardiac Tamponade|Surgical Reintervention
Interventions: DEVICE: Blake Drains (Blake drain, Ethicon USA)|DEVICE: Standard mediastinal drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evolocumab Plus Ezetimibe in Haemodialized Statin-intolerant Patients With Hypercholesterolemia
Status: UNKNOWN
Conditions: Hypercholesterolemia|CKD Stage 5|Chronic Kidney Disease Requiring Chronic Dialysis
Interventions: DRUG: Evolocumab|DRUG: Ezetimibe|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lidocaine Patch for Treatment of Persistent Inguinal Postherniorrhaphy Pain
Status: COMPLETED
Conditions: Inguinal Pain
Interventions: DRUG: lidocaine patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of BMS-663513 Administered in Combination With Chemotherapy to Subjects With Advanced Solid Malignancies
Status: TERMINATED
Conditions: Advanced Solid Malignancies
Interventions: DRUG: BMS-663513
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Protein C Levels in Severe Sepsis Patients on Drotrecogin Alfa (Activated)
Status: COMPLETED
Conditions: Severe Sepsis
Interventions: DRUG: Drotrecogin alfa (activated)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Triheptanoin for Treatment of Long-Chain Fatty Acid Oxidation Disorder
Status: COMPLETED
Conditions: Very Long-chain acylCoA Dehydrogenase (VLCAD) Deficiency|Carnitine Palmitoyltransferase 2 (CPT2) Deficiency|Mitochondrial Trifunctional Protein (TFP) Deficiency|Long-chain 3 hydroxyacylCoA Dehydrogenase (LCHAD) Deficiency
Interventions: DRUG: Triheptanoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot and Feasibility Study of Hematopoietic Stem Cell Gene Transfer for the Wiskott-Aldrich Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Wiskott-Aldrich Syndrome
Interventions: BIOLOGICAL: Retrovirus-mediated gene transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of the Effect on Blood Pressure of an Equivalent Content of Sodium in the Form of Bicarbonate of Sodium and in the Form of Sodium Chloride, on "Sensitive Sodium" Subjects
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: Sodium Bicarbonate and Sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PREPARE- Prehabilitation for Patients Awaiting Liver Transplantation: Feasibility and Acceptability Testing.
Status: RECRUITING
Conditions: Liver Transplant
Interventions: BEHAVIORAL: Prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Cardiac Surgery
Status: NOT_YET_RECRUITING
Conditions: Cardiac Valve Disease
Interventions: BIOLOGICAL: fresh frozen plasma|BIOLOGICAL: prothrombin complex concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of the MobiusHD® in Renal Hemodialysis Subjects With Uncontrolled Hypertension
Status: WITHDRAWN
Conditions: Uncontrolled Hypertension
Interventions: DEVICE: MobiusHD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Remote Ischemic Conditioning for Patients Taking Off-pump Coronary Artery Bypass Grafting
Status: RECRUITING
Conditions: Coronary Artery Bypass Grafting|Remote Ischemic Conditioning|Ischemia-Reperfusion Injury
Interventions: DEVICE: Remote ischemic conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Non-invasive Assessment of Liver Stiffness/Fibrosis by Transient Elastography (Fibroscan) in Patients With Left and/or Right Sided Heart Failure
Status: COMPLETED
Conditions: Liver Fibrosis|Heart Failure
Interventions: DEVICE: FibroScan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p