pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Standing, Stepping and Voluntary Movement Spinal Cord Epidural Stimulation
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Cord Injuries
Interventions: OTHER: Standing and Stepping|DEVICE: Standing, Stepping and Voluntary Movement with spinal cord Epidural Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphoblastic Leukemia|B Acute Lymphoblastic Leukemia|Mixed Phenotype Acute Leukemia|T Acute Lymphoblastic Leukemia
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Calaspargase Pegol|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Daunorubicin Hydrochloride|DRUG: Dexamethasone|DRUG: Dexrazoxane Hydrochloride|DRUG: Doxorubicin|DRUG: Etoposide|BIOLOGICAL: Filgrastim|DRUG: Ifosfamide|DRUG: Imatinib Mesylate|OTHER: Laboratory Biomarker Analysis|DRUG: Leucovorin Calcium|DRUG: Mercaptopurine|DRUG: Mercaptopurine|DRUG: Methotrexate|DRUG: Methylprednisolone|DRUG: Pegaspargase|DRUG: Prednisolone|OTHER: Questionnaire Administration|DRUG: Therapeutic Hydrocortisone|DRUG: Thioguanine|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cut Down on Carbohydrate in the Dietary Therapy of Type 2 Diabetes - The Meal Box Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus Type 2|Overweight and Obesity
Interventions: OTHER: Carbohydrate-reduced high-protein (CRHP) Diet|OTHER: Conventional diabetes (CD) Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Use of Fractional Flow Reserve in CABG Use and Effectiveness of FFR-based CABG in Real-life Practice
Status: WITHDRAWN
Conditions: Fracational Flow Reserve|Coronary Artery Disease|Coronary Artery Bypass Surgery
Interventions: PROCEDURE: Fractional Flow reserve
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Memory Reconsolidation Blockade for Treating Drug Addiction
Status: COMPLETED
Conditions: Substance Dependence
Interventions: DRUG: Propranolol and memory reactivation|DRUG: Placebo and memory reactivation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of HER2+ Breast Cancer Patients With Active Brain Metastases Treated With Afatinib & T-DM1 vs. T-DM1 Alone
Status: UNKNOWN
Conditions: HER2-positive Breast Cancer|Brain Metastases
Interventions: DRUG: Afatinib|DRUG: T-DM1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Angulated Screw-retained Crowns Following Immediate Implant Placement
Status: COMPLETED
Conditions: Tooth Diseases
Interventions: PROCEDURE: Immediate implant placement|PROCEDURE: Angulated screw-retained crowns placement|PROCEDURE: Cemented crowns placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acceptability of Depo-subQ Provera 104 in Uniject vs. Intramuscular Depo-Provera Among HIV+ Women & Providers, Uganda
Status: COMPLETED
Conditions: Acceptability of Different Contraceptive Injection Types
Interventions: DRUG: DepoSubQ Provera 104 in Uniject|DRUG: Intramuscular DMPA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Ticagrelor Versus Cilostazol in Minor Ischemic Stroke or TIA
Status: RECRUITING
Conditions: Ischemic Stroke
Interventions: DRUG: Ticagrelor 90 MG|DRUG: Cilostazol 100 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Fluid Extract of Chamomilla Tincture for Oral Aphthae
Status: COMPLETED
Conditions: Recurrent Aphthous Stomatitis
Interventions: DRUG: chamomilla tincture mouthwash|DRUG: placebo mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Modified Constraint-Induced Movement Therapy Program in Rehabilitation of Arm Paresis in Children With Cerebral Palsy
Status: COMPLETED
Conditions: Hemiparesis|Cerebral Palsy
Interventions: BEHAVIORAL: Modified Constraint-induced movement therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Multidisciplinary Recovery After Surgery Program in Orthopedics and Traumatology
Status: UNKNOWN
Conditions: Hip Fractures|Knee Fracture|Hip Arthritis|Knee Arthritis
Interventions: PROCEDURE: Multidisciplinary Recovery Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ART-3 Pilot - Driving Pressure Limited Ventilation for Patients Without ARDS (ART3pilot)
Status: WITHDRAWN
Conditions: Mechanical Ventilation|Acute Respiratory Distress Syndrome
Interventions: OTHER: Driving pressure limited ventilation|OTHER: Conventional ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dental Appliance to Treat SDB in Children
Status: RECRUITING
Conditions: Snoring|Apnea, Obstructive|Upper Airway Resistance Syndrome|Sleep-Disordered Breathing
Interventions: DEVICE: Vivos Grow/Vivos Way Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crystalloids Versus Colloids Versus Hypertonic Saline as a Co-load During Spinal Anesthesia.
Status: COMPLETED
Conditions: Spinal Anaesthesia
Interventions: PROCEDURE: Normal saline|PROCEDURE: hydroxyethyl starch|PROCEDURE: Hypertonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Randomized Study of Amplimexon (Imexon) With Gemcitabine in Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Neoplasms
Interventions: DRUG: imexon in combination with gemcitabine|DRUG: imexon placebo + gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BYL719 and Nab-Paclitaxel in Locally Recurrent or Metastatic HER-2 Negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: BYL-719 (alpelisib)|DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: HER2-positive Breast Cancer
Interventions: DRUG: tucatinib|DRUG: placebo|DRUG: T-DM1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Immune Response to, and Safety of, Fluviral and Fluzone Influenza Vaccines in Persons 50 y.o. and Over
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza virus vaccine (Fluviral)|BIOLOGICAL: Influenza virus vaccine (Fluzone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: ECT
Clinical trial: Adalimumab in Axial Spondyloarthritis (ASIM) - MRI and Biomarkers in Patients With Spondyloarthritis
Status: COMPLETED
Conditions: Spondyloarthritis
Interventions: DRUG: Adalimumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Once Daily (OD) Versus Three Times Daily (TID) Dosing With Mesalazine Granules for Prevention of Recurrence of Ulcerative Colitis (UC)
Status: COMPLETED
Conditions: Colitis, Ulcerative|Recurrence
Interventions: DRUG: mesalamine granules|DRUG: mesalamine granules|DRUG: mesalamine granules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Severe/Uncontrolled Asthma From General Population to Clinical Setting: Update and Follow-up of the RItA Registry
Status: NOT_YET_RECRUITING
Conditions: Asthma|Asthma Severe Persistent Uncontrolled
Interventions: OTHER: Routine medical care|OTHER: Telephone interview
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Emdogain Implementation With Transcrestal Sinus Lifting and Dental Implant Placement
Status: COMPLETED
Conditions: Osseointegration Failure of Dental Implant|Bone Density Increased
Interventions: DRUG: Enamel Matrix Protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Combination With Chemotherapy for Patients With Untreated B Cell Lymphoma
Status: RECRUITING
Conditions: B Cell Lymphoma|Lymphoma|Lymphoma, B-Cell|Diffuse Large B Cell Lymphoma|High-grade B-cell Lymphoma
Interventions: DRUG: Pembrolizumab|DRUG: R-CHOP Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Vismodegib (GDC-0449) in Patients Treated With Vismodegib in a Previous Genentech-sponsored Phase I or II Cancer Study
Status: COMPLETED
Conditions: Ovarian Cancer|Basal Cell Carcinoma|Metastatic Colorectal Cancer
Interventions: DRUG: Vismodegib|DRUG: FOLFOX|DRUG: FOLFIRI|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Progressive Resistance Training Compared to Neuromuscular Exercise in Patients With Hip Osteoarthritis
Status: COMPLETED
Conditions: Hip Osteoarthritis
Interventions: OTHER: Progressive Resistance Training and no booster sessions|OTHER: Progressive Resistance Training and booster sessions|OTHER: Neuromuscular exercise and no booster sessions|OTHER: Neuromuscular exercise and booster sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Patient-Centred, Multidisciplinary Opioid Tapering Program for Individuals With Chronic Non-Cancer Pain on Long Term Opioid Therapy
Status: COMPLETED
Conditions: Opioid Use|Opioids; Harmful Use|Hyperalgesia|Pain, Chronic
Interventions: BEHAVIORAL: Patient Education Workshop (PEWs)|PROCEDURE: Multidisciplinary Tapering Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Test Long-term Safety of Iclepertin in People With Schizophrenia Who Took Part in a Previous CONNEX Study
Status: RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: Iclepertin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of BMX-010 in Adult Subjects With Atopic Dermatitis
Status: TERMINATED
Conditions: Atopic Dermatitis
Interventions: DRUG: BMX-010|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Visual Field Infiltration of Tranexamic Acid Reduced the Blood Loss in Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Total Knee Arthroplasty
Interventions: DRUG: Tranexamic Acid 100 MG/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypotension Prediction 2 Study in Cardiac Surgery and Postoperative ICU Admission
Status: COMPLETED
Conditions: Intraoperative Hypotension|Postoperative Hypotension|Hypotension
Interventions: OTHER: HPI guided treatment advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Opioid & Steroid Use Following Tonsillectomy in Pediatric Patients
Status: TERMINATED
Conditions: Pain, Postoperative
Interventions: DRUG: Dexamethasone|DRUG: Analgesics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Raloxifene and Rimostil for Perimenopause-Related Depression
Status: COMPLETED
Conditions: Perimenopausal Depression|Depression
Interventions: DRUG: Raloxifene|DRUG: Rimostil|DRUG: Transdermal Estradiol|DRUG: Placebo skin patch and placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mobilization Protocol for Knee Arthroplasty Patients
Status: COMPLETED
Conditions: Pain|Anxiety|Physical Function|Mobility|Arthroplasty
Interventions: OTHER: Mobilization protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Pharmacokinetics of Escalating Doses of DNIB0600A in Participants With Non-Small Cell Lung Cancer (NSCLC) and Platinum Resistant Ovarian Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer, Ovarian Cancer
Interventions: DRUG: DNIB0600A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Multi Regional Clinical Trial (MRCT) of Tricaprilin in Mild to Moderately Severe Probable Alzheimer's Disease With Optional Open Label Extension
Status: WITHDRAWN
Conditions: Alzheimer's Disease
Interventions: DRUG: Tricaprilin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IOLMASTER 700 Central Topography Workflow Study.
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: IOLMaster 700 with central topography|DEVICE: IOLMaster 700 without central topography plus Cassini|DEVICE: IOLMaster 700 without central topography plus Pentacam
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate Rate of Nausea in Healthy Premenopausal Female Subjects Treated With Single Dose of Bremelanotide Alone or With Zofran
Status: COMPLETED
Conditions: Nausea
Interventions: DRUG: Bremelanotide|DRUG: Zofran|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Continuous Moderate Training and Reduced High Intensity Interval Training in Obese Young Adults
Status: COMPLETED
Conditions: Obesity|Exercise|Oxygen Consumption
Interventions: OTHER: REHIT Exercise|OTHER: Continuous Aerobic Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Ablation in Treating Patients With Bone Metastases
Status: COMPLETED
Conditions: Metastatic Cancer|Pain|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: PROCEDURE: pain therapy|PROCEDURE: radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase Ⅲ, Clinical Trial to Compare an Inactivated Quadrivalent Influenza Vaccine and a Licensed Vaccine in Chile
Status: UNKNOWN
Conditions: Influenza|Vaccines
Interventions: DRUG: Tetravalent influenza vaccine developed by Sinovac Biotech Co.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer
Status: TERMINATED
Conditions: Cancer
Interventions: DRUG: cyproheptadine hydrochloride|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Pranayamic Techniques on Obstructive Sleep Apnea Syndrome
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea Syndrome
Interventions: OTHER: Ujjayi pranayama, Nadi-Shodhana pranayama, Sukha pranayama
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Tislelizumab in Combination With BCG in HR-NMIBC Patients (TACBIN-01)
Status: UNKNOWN
Conditions: Urinary Bladder Neoplasms|Urologic Neoplasms|Urogenital Neoplasms|Antineoplastic Agents|Urinary Bladder Diseases|Tislelizumab Antineoplastic Agents, Immunological
Interventions: DRUG: tislelizumab and BCG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S9007, Study of Bone Marrow and Blood Samples From Patients With Leukemia or Other Hematopoietic Cancers
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: GENETIC: cytogenetic analysis|GENETIC: fluorescence in situ hybridization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Naturlose (D-Tagatose) Efficacy Evaluation Trial
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Tagatose|DRUG: Sugar Substitute Splenda
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Blood Sampling Technique on the Total Amount of Blood Collected for Laboratory Testing Critically Ill Pediatric Patients
Status: NOT_YET_RECRUITING
Conditions: Iatrogenic Anaemia
Interventions: PROCEDURE: In line sampling|PROCEDURE: Standard blood sampling technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Patients With Chronic Hepatitis B.
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: peginterferon alfa-2a [Pegasys]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Primary Uncemented Partly Ti-coated Total Hip Prosthesis With and Without HA, and Alumina-on-alumina Articulation
Status: UNKNOWN
Conditions: Survival of the Implants With Revision as Endpoint|Clinical Performance With HHS|Patients Satisfaction With the Hip Implant
Interventions: PROCEDURE: Uncemented primary total hip arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Toripalimab in Combination With Chemotherapy as Induced Chemotherapy for Localized Hypopharyngeal Cancer
Status: UNKNOWN
Conditions: Hypopharyngeal Squamous Cell Carcinoma
Interventions: DRUG: induction chemotherapy|PROCEDURE: surgery|RADIATION: chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total Hemihepatic Vascular Exclusion in Hepatectomy in Hepatocellular Carcinoma Treatment
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: Total hemihepatic vascular exclusion|PROCEDURE: Hemihepatic vascular Clamping|PROCEDURE: Pringle's Maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SodiUm SeleniTe Adminstration IN Cardiac Surgery (SUSTAIN CSX®-Trial).
Status: UNKNOWN
Conditions: Heart Disease
Interventions: DRUG: sodium selenite|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Mycophenolate Mofetil in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Mycophenolic Acid|DRUG: Mycophenolate 7-O-Phenolic Glucuronide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Masked, Controlled, Single Site Investigator Initiated, Exploratory Study of the Midazolam/Ketamine Melt vs Ketamine Melt Alone vs Midazolam Melt Alone in Subjects Undergoing Intraocular Surgery.
Status: UNKNOWN
Conditions: Anesthesia
Interventions: DRUG: Midazolam/Ketamine HCl 3mg-50mg sublingual|DRUG: Midazolam 3mg Sublingual|DRUG: Ketamine 50mg Sublingual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The eyeGuide: Improving Glaucoma Self-management With a Personalized Behavior Change Program
Status: COMPLETED
Conditions: Medication Adherence|Glaucoma
Interventions: BEHAVIORAL: eyeGuide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: SU5416 and Paclitaxel in Treating Patients With Recurrent, Locally Advanced or Metastatic Cancer of the Head and Neck
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: paclitaxel|DRUG: semaxanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Centre Prospective Evaluation of 68Gallium-FAPI PET/MRI in Hepatocellular Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Radiolabelled tracer, 68Gallium-FAPI-46 PET/MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Inhaled Treprostinil in Patients With PAH
Status: WITHDRAWN
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Inhaled treprostinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OUTREACH: Urine Analysis and Antihypertensive Treatment
Status: COMPLETED
Conditions: Hypertension|Adherence, Medication
Interventions: OTHER: HPLC-MS/MS-guided intervention|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo.
Status: COMPLETED
Conditions: Alpha 1-Antitrypsin Deficiency|Emphysema|COPD
Interventions: DRUG: Placebo Oral Tablet|DRUG: Alvelestat oral tablet - dose 1|DRUG: Alvelestat oral tablet - dose 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Care, Accelerating Recovery and Education
Status: RECRUITING
Conditions: Mental Health Disorder|Suicide Attempt|Suicidal Ideation|Emergency Psychiatric
Interventions: BEHAVIORAL: Improving Care, Accelerating Recovery & Education (ICARE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Second Line Therapy for Advanced Intrahepatic Cholangiocarcinoma
Status: NOT_YET_RECRUITING
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: DRUG: Regorafenib and HAIC|DRUG: FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Blood Flow Restriction (BFR) on Exercise and Hemodynamic Responses
Status: TERMINATED
Conditions: Exercise Training|Hemodynamic Response
Interventions: DEVICE: Hokanson Cuffs|DEVICE: BStrong Bands
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Suicide Prevention Among Recipients of Care
Status: ACTIVE_NOT_RECRUITING
Conditions: Suicide|Suicide, Attempted|Suicidal Ideation|Social Support|Secondary Prevention|Patient Care Planning|Outpatients|Outpatient Clinics, Hospital|Mental Health Services|Mental Health|Mental Disorder|Loneliness|Emergency Service, Hospital|Depressive Disorder|Depression|Continuity of Patient Care|Ambulatory Care|Adolescent|Adult|Crisis Intervention
Interventions: BEHAVIORAL: SPI+|BEHAVIORAL: SP+CC (Caring Contacts)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: AOP2014 vs. BAT in Patients With Polycythemia Vera Who Previously Participated in the PROUD-PV Study.
Status: COMPLETED
Conditions: Polycythemia Vera
Interventions: DRUG: Pegylated-Proline-interferon alpha-2b|DRUG: Best available therapy (BAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV
Status: COMPLETED
Conditions: Hypothermia
Interventions: PROCEDURE: Hypothermia prevention with plastic bag|PROCEDURE: Hypothermia prevention without plastic bag
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of PF-06700841 in Healthy Participants
Status: COMPLETED
Conditions: Heathy Participants
Interventions: DRUG: PF-06700841|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Use of a Remote Monitoring and Follow-up Option for Patients With Chronic Obstructive Pulmonary Disease (BOREAL)
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: BORA Band (wristband)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PK Study of 90-Day Use of Vaginal Rings Containing Dapivirine and Levonorgestrel
Status: COMPLETED
Conditions: Healthy|Contraception|Contraceptive Usage|Women
Interventions: DRUG: VR: 200 mg DPV + 320 mg LNG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Low Level Laser Therapy on Pain Induced by Placement of Orthodontic Separators in Pediatric Patients
Status: WITHDRAWN
Conditions: Levels of Pain
Interventions: DEVICE: Epic 10 Diode Laser by Biolase Inc.|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Changes in the Parameters of Optical Coherence Tomography After Intravitreal Injection of Lucentis
Status: UNKNOWN
Conditions: Degeneration of Macula and Posterior Pole
Interventions: BIOLOGICAL: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Eszopiclone on Sleep-dependent Learning in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: eszopiclone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Study to Evaluate the Preliminary Safety, Efficacy, PK and PD of Bryostatin 1 in Patients With Alzheimer's Disease
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: Bryostatin 1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of YHB1411-2 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Rheumatic Arthritis
Interventions: BIOLOGICAL: YHB1411-2: Level 2|BIOLOGICAL: YHB1411-2: Level 3|BIOLOGICAL: YHB1411-2: Level 4|BIOLOGICAL: YHB1411-2: Level 5|BIOLOGICAL: Placebo|BIOLOGICAL: YHB1411-2: level 1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Observational Study of First-Line Bevacizumab (Avastin) With Fluoropyrimidine-Based Chemotherapy in Participants With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Bevacizumab|DRUG: Chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Redirected Autologous T Cells Engineered to Contain Anti-CD19 Attached to TCR and 4-1BB Signaling Domains in Patients With Chemotherapy Resistant or Refractory Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Patients With B Cell ALL, Relapsed or Refractory, With no Available Curative Treatment Options
Interventions: BIOLOGICAL: CART-19|BIOLOGICAL: CART-19|BIOLOGICAL: CART-19|BIOLOGICAL: CART-19
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Firefighter Collaborative Research Project
Status: RECRUITING
Conditions: Exposure|Cardiopulmonary
Interventions: BEHAVIORAL: Blood Donation|BEHAVIORAL: Plasma Donation|BEHAVIORAL: Zone 2 Training|BEHAVIORAL: Intermittent Fasting|BEHAVIORAL: Surveys
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: To Evaluate Efficacy and Safety in TG-2349 Combination With DAG181 (± Ribavirin) in HCV Genotype I Infected Patients
Status: COMPLETED
Conditions: Chronic Hepatics C Virus (HCV) Genotype 1|Non-Cirrhotic|Cirrhosis|Treatment naïve
Interventions: DRUG: non-cirrhotic subjects. low TG-2349+ low DAG181+Ribavirin|DRUG: non-cirrhotic subjects. high TG-2349+ high DAG181+Ribavirin|DRUG: non-cirrhotic subjects. low TG-2349+ low DAG181|DRUG: non-cirrhotic subjects. high TG-2349+ high DAG181|DRUG: cirrhotic subjects. high TG-2349+ high DAG181+Ribavirin|DRUG: cirrhotic subjects. high TG-2349+ high DAG181
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Efficacy of Ablative Fractional Laser-assisted Photodynamic Therapy for Treatment of Lower Extremity Bowen's Disease
Status: COMPLETED
Conditions: Bowen's Disease
Interventions: DRUG: lidocaine-prilocaine 5% cream application|DEVICE: 2940-nm Er:YAG AFL pretreatment|DRUG: methyl-aminolevulinate application|DEVICE: Illuminating using red light-emitting diode lamps
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thorough Corrected QT Interval (QTc) Study To Evaluate Possible Effects of Prucalopride on ECG Parameters
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: prucalopride|DRUG: moxifloxacin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 7 Days Versus 14 Days of Antibiotics for Neonatal Sepsis
Status: COMPLETED
Conditions: Infant, Newborn|Neonatal SEPSIS|Anti-bacterial Agents|Recurrence
Interventions: DRUG: 7-day course of antibiotics|DRUG: 14-day course of antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness Of Therapy With A Thermal Water Nasal Aerosol In Children With Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis (Disorder)
Interventions: OTHER: thermal waters nasal irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of SOF/VEL/VOX FDC for 12 Weeks and SOF/VEL for 12 Weeks in DAA-Experienced Adults With Chronic HCV Infection Who Have Not Received an NS5A Inhibitor
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: SOF/VEL/VOX|DRUG: SOF/VEL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Artificial Induction of Labour in Full-term Singleton Pregnancy : Comparative Randomized Trial of Two Strategies
Status: COMPLETED
Conditions: Pregnancy Related
Interventions: PROCEDURE: Vaginal Dinoprostone system (Propess®)|PROCEDURE: Dilatation balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tamoxifen Dose Adjustment on Indonesian Female ER+ Breast Cancer Patients Based on CYP2D6 Genotype and Endoxifen Levels
Status: COMPLETED
Conditions: ER+ Breast Cancer
Interventions: DRUG: Tamoxifen dose adjustment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pivotal Study to Evaluate Efficacy and Safety of SP5M001 Inj. as Compared to Synovian Inj. in Patients With Mild to Moderate Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis Thumb
Interventions: DRUG: SP5M001 inj|DRUG: Synovian inj
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gabapentin and Tizanidine for Insomnia in Chronic Pain
Status: ENROLLING_BY_INVITATION
Conditions: Insomnia Due to Medical Condition|Chronic Pain
Interventions: DRUG: Gabapentin|DRUG: Placebo|DRUG: Tizanidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study to Assess the Safety and Efficacy of Pitolisant in Adult Patients With Idiopathic Hypersomnia
Status: COMPLETED
Conditions: Idiopathic Hypersomnia
Interventions: DRUG: Pitolisant Oral Tablet|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Umbilical Cord Mesenchymal Stem Cells and Liraglutide in Diabetes Mellitus
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: GLP-1|BIOLOGICAL: SC|OTHER: Standard Medical Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sitagliptin Reduces Left Ventricular Mass in Normotensive Type 2 Diabetic Patients With Coronary Artery Disease
Status: COMPLETED
Conditions: Newly Diagnosed Type 2 Diabetes|Coronary Artery Disease
Interventions: DRUG: Sitagliptin and acarbose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Sacubitril/Valsartan on Autonomic Cardiac Nervous System in Heart Failure Patients: an Exploratory Study
Status: COMPLETED
Conditions: Heart Failure Patients
Interventions: DRUG: sacubitril/ valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Vigil for Participants With Ovarian Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer|Ovarian Neoplasms
Interventions: BIOLOGICAL: Vigil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Role of Oncostatin M in Head and Neck Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Head and Neck Cancer|Cytokine
Interventions: OTHER: Biopsies and Blood collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacokinetics of GH001 Delivered Via a Proprietary Aerosol Delivery Device in Healthy Subjects
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: 5 Methoxy N,N Dimethyltryptamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRINCE (PSMA-lutetium Radionuclide Therapy and ImmuNotherapy in Prostate CancEr)
Status: COMPLETED
Conditions: Metastatic Castration Resistant Prostate Cancer
Interventions: DRUG: Pembrolizumab|DRUG: 177Lu-PSMA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protocolized Reduction of Non-resuscitation Fluids Versus Usual Care in Septic Shock Patients
Status: RECRUITING
Conditions: Septic Shock
Interventions: OTHER: Protocolised reduction of non-resuscitation fluids|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ottawa Sunglasses at Night for Mania Study
Status: RECRUITING
Conditions: Mania|Sleep|Bipolar Disorder
Interventions: DEVICE: Blue-blocking glasses|DEVICE: Lightly-tinted glasses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Detection of miRNAs in HPA Axis Function in Healthy Subjects
Status: TERMINATED
Conditions: Dexamethasone Effect on miRNA Profile in Healthy Humans
Interventions: DRUG: Dexamethasone 4mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A 6-Week Multicenter Trial Of Varenicline Tartrate For Cognitive Impairment In Subjects With Schizophrenia
Status: WITHDRAWN
Conditions: Schizophrenia
Interventions: DRUG: placebo|DRUG: varenicline|DRUG: varenicline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Administration of Hyperthermic Intraperitoneal Chemotherapy in the General Ward
Status: NOT_YET_RECRUITING
Conditions: Epithelial Ovarian Cancer
Interventions: PROCEDURE: China Hyperthermic Intraperitoneal Chemotherapy(C-HIPEC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Viaskin Peanut in Peanut-allergic Young Children 1-3 Years of Age
Status: ACTIVE_NOT_RECRUITING
Conditions: Peanut Allergy
Interventions: BIOLOGICAL: Viaskin Peanut 250 mcg|BIOLOGICAL: Viaskin Peanut 100 mcg|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Actium-225-Prostate Specific Membrane Antigen Imaging & Therapy
Status: RECRUITING
Conditions: Prostatic Neoplasms, Castration-Resistant
Interventions: RADIATION: Radionuclide Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and Bioequivalence Comparison of Baclofen and Chlorzoxazone Administered Individually or Concurrently
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Baclofen 20 mg Tablet|DRUG: Chlorzoxazone 500 mg Tablet|DRUG: Baclofen 20mg tablet and Chlorzoxazone 500 mg tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of 60 Days Powdered Tart Cherry Supplementation on Metabolic Syndrome
Status: RECRUITING
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Powdered tart cherry|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab for Treatment of Recurrent Respiratory Papillomatosis (RRP)
Status: COMPLETED
Conditions: Recurrent Respiratory Papillomatosis
Interventions: DRUG: Avastin® (bevacizumab)|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tafenoquine in Patients With Mild to Moderate COVID-19
Status: COMPLETED
Conditions: COVID 19 Disease
Interventions: DRUG: Tafenoquine Oral Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BOLSTER: Building Out Lifelines for Safety, Trust, Empowerment and Renewal
Status: COMPLETED
Conditions: Gynecologic Cancer|Gastrointestinal Cancer
Interventions: BEHAVIORAL: BOLSTER|OTHER: Enhanced Discharge Planning (EDP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of a Metal Backed Fixed-Bearing Tibial Baseplate and an All-Polyethylene Tibia in Total Knee Arthroplasty
Status: TERMINATED
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: TKA surgery with modular polished tibial baseplate/XLK design|PROCEDURE: TKA surgery with the nonmodular APT/GVF design|DEVICE: P.F.C.® Sigma Knee System|DEVICE: P.F.C.® Sigma Knee System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Albumin-bound Paclitaxel Combined With Gemcitabine First-line Inoperable Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: albumin-bound paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of a Single Dose of Inclacumab to Reduce Re-admission in Participants With Sickle Cell Disease and Recurrent Vaso-occlusive Crises
Status: TERMINATED
Conditions: Sickle Cell Disease|Vaso-occlusive Crisis|Vaso-occlusive Pain Episode in Sickle Cell Disease
Interventions: DRUG: Inclacumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Explore the Relationships Among Immunity and Stress and the Symptoms of Fatigue, Pain, and Mood Following Guided Imagery in Women With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: OTHER: Guided Imagery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Safety and Immunogenicity of Multivalent Pneumococcal Vaccines in Japanese Adults 18 to 49 Years of Age
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: Prevnar 13|BIOLOGICAL: multivalent pneumococcal conjugate formulation 1|BIOLOGICAL: multivalent pneumococcal conjugate formulation 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clevidipine Infusion for Blood Pressure Management After Successful Revascularization in Acute Ischemic Stroke
Status: RECRUITING
Conditions: Stroke, Acute|Blood Pressure|Mechanical Thrombectomy
Interventions: DRUG: Clevidipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Soleus Muscle Push Ups on Oxidative Stress and Inflammatory Markers, Soleus Endurance, and Adipocytokines Between Type 2 Diabetic, Overweight/Obese and Normal Weight Individuals.
Status: NOT_YET_RECRUITING
Conditions: Diabete Type 2|Obesity|Overweight
Interventions: OTHER: Soleus Muscle Push Up Exercise|OTHER: Other Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maintenance Azacitidine in Elderly Patients With Acute Myeloid Leukemia (AML) in CR After Induction Chemotherapy
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The POST Study; POsterior Shoulder Tightness in Rotator Cuff Related Disorders
Status: COMPLETED
Conditions: Shoulder Impingement Syndrome
Interventions: OTHER: Manual therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT