pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: OTO-313 in Subjects With Subjective Tinnitus
Status: COMPLETED
Conditions: Tinnitus, Subjective
Interventions: DRUG: OTO-313|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Anorectal Function in Patients With Inflammatory Bowel Disease
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases|Irritable Bowel Syndrome
Interventions: OTHER: Exposure 1: Visceral hypersensitivity or phenotype suggestive of IBS|OTHER: Exposure 2: Changes in anorectal motor function or compliance.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Vagus Stimulation on Peripheral Glucose Metabolism
Status: COMPLETED
Conditions: Insulin Resistance|Glucose Intolerance
Interventions: DEVICE: Transauricular vagus nerve stimulation|DEVICE: Transauricular sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pre-pectoral Versus Sub-pectoral Implant Placement in Immediate Breast Reconstruction
Status: UNKNOWN
Conditions: Mastectomy|Breast Cancer
Interventions: PROCEDURE: immediate acellular dermal matrix-assisted implant-based breast reconstruction with prepectoral implant placement.|PROCEDURE: Immediate acellular dermal matrix-assisted implant-based breast reconstruction with subpectoral implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Treatment of Acute Pulmonary Thromboembolism (PE) of GSK576428 (Fondaparinux Sodium) in Japanese Patients
Status: COMPLETED
Conditions: Embolism, Pulmonary
Interventions: DRUG: Fondaparinux sodium|DRUG: unfractionated heparin (UFH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Yttrium-90 Ibritumomab Tiuxetan Plus High-Dose BEAM Followed By ASCT For Relapsed B-Cell Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: carmustine|DRUG: cytarabine|DRUG: etoposide|DRUG: melphalan|PROCEDURE: ASCT|RADIATION: yttrium Y 90 ibritumomab tiuxetan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Pharmacokinetics of Leuprolide Mesylate in Subjects With Central Precocious Puberty
Status: RECRUITING
Conditions: Puberty; Precocious, Central
Interventions: DRUG: Leuprolide Mesylate, Subcutaneous injection of 42 mg Leuprolide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective, Randomised, Single-Blinded, Monocentric Clinical Study to Compare Postoperative Analgesia and Outcome After Combined Paravertebral and Intrathecal Versus Thoracic Epidural Analgesia for Thoracotomy
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: PROCEDURE: intrathecal opioids and thoracic paravertebral analgesia|PROCEDURE: thoracic epidural analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Study About Safety and Efficacy of Pirfenidone to Treat Grade 2 or Grade3 Radiation-induced Lung Injury.
Status: TERMINATED
Conditions: Radiation-induced Lung Injury
Interventions: DRUG: Pirfenidone|DRUG: basic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Novel Biomarkers of Kidney Dysfunction at Liver Transplant
Status: COMPLETED
Conditions: Liver Transplantation|Liver Transplant; Complications|Kidney Dysfunction
Interventions: DIAGNOSTIC_TEST: Blood sample for serum and plasma biomarkers:|DIAGNOSTIC_TEST: Urine sample for biomarkers|DIAGNOSTIC_TEST: Cardiac bio-impedance (Cardioscreen Medis)|DIAGNOSTIC_TEST: Aortic pulse wave velocity (APWV) (TensioMed and SphygmoCor)|DIAGNOSTIC_TEST: Optical Coherence Tomography (Spectralis OCT)|DIAGNOSTIC_TEST: Arterial Spin Labelling Magnetic Resonance Imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Consolidation Pembrolizumab After Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Pembrolizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment of Insulin Fast Dissolving Film in Treatment of Post Infection Anosmia
Status: COMPLETED
Conditions: Anosmia
Interventions: COMBINATION_PRODUCT: Insulin film|DEVICE: Fast dissolving film
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Astroscape: A Study of Radiprodil on Safety, Tolerability, Pharmacokinetics, and Effect on Seizures and Behavioral Symptoms in Patients With TSC or FCD Type II
Status: RECRUITING
Conditions: Tuberous Sclerosis Complex|Focal Cortical Dysplasia
Interventions: DRUG: Radiprodil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Spironolactone for the Prevention of Electrolyte Abnormalities in Patients Treated With Amphotericin B
Status: TERMINATED
Conditions: Patients With Fungic Infections
Interventions: DRUG: Spironolactone 100mg|DRUG: Spironolactone 200mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence of a FDC Tablet of Linagliptin/Metformin (2.5mg/750mg) Extended Release in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Linagliptin|DRUG: Linagliptin/Metformin ER FDC|DRUG: Metformin ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diaphragmatic Work During HFNC and CPAP Support
Status: RECRUITING
Conditions: Respiratory Insufficiency in Children|Newborn Rds|Nasal Cannula|CPAP Ventilation
Interventions: DEVICE: Non invasive ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Gemcitabine/Cisplatin for Resected Pancreas Cancer: Establishing the Role of ERCC1 in Treatment Decision
Status: TERMINATED
Conditions: Pancreatic Neoplasms|Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Urodynamic Changes in Chronic Kidney Disease Patients and Does Insertion of Urinary Catheter Delay the Need for Kidney Dialysis
Status: UNKNOWN
Conditions: Renal Insufficiency, Chronic
Interventions: DEVICE: urinary catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Follow-up Study for Participants of Kite-Sponsored Interventional Studies Treated With Gene-Modified Cells
Status: ENROLLING_BY_INVITATION
Conditions: Solid and Hematological Malignancies
Interventions: BIOLOGICAL: Axicabtagene Ciloleucel|BIOLOGICAL: Brexucabtagene Autoleucel|BIOLOGICAL: KITE-585|BIOLOGICAL: KITE-718|BIOLOGICAL: KITE-439|BIOLOGICAL: KITE-222|BIOLOGICAL: KITE-363
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dasatinib, Temsirolimus, and Cyclophosphamide in Treating Patients With Advanced, Recurrent, or Refractory Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Recurrent Brain Neoplasm|Recurrent Malignant Solid Neoplasm|Refractory Brain Neoplasm
Interventions: DRUG: Cyclophosphamide|DRUG: Dasatinib|OTHER: Laboratory Biomarker Analysis|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Foot and Hip Abductor Strengthening in Patients With Knee Osteoarthritis.
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Hip abductor strengthening exercise|OTHER: Intrinsic foot muscle strengthening along with conventional exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Bridging Trial Comparing Sugammadex (Org 25969) at Reappearance of T2 in Japanese and Caucasian Participants. Part A: Japanese Participants (P05956)
Status: COMPLETED
Conditions: Anesthesia, General
Interventions: DRUG: sugammadex|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-arm, Open-label, Phase II Trial of HD-tDCS in Fibromyalgia Patients
Status: COMPLETED
Conditions: Fibromyalgia|Chronic Pain
Interventions: DEVICE: High Definition transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interaction of ASN51 With Fluvoxamine, Itraconazole and Paroxetine in Healthy Subjects
Status: RECRUITING
Conditions: Drug Drug Interaction
Interventions: DRUG: Fluvoxamine|DRUG: Itraconazole|DRUG: Paroxetine|DRUG: ASN51
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: This Was a Clinical Study Investigating the Moisturization and Desquamation Effect of AmLactin® Rapid Relief Restoring Lotion + Ceramides on Dry Skin in Healthy Female Volunteers. AmLactin® Rapid Relief is an Over-the-counter Cosmetic
Status: COMPLETED
Conditions: Dry Skin
Interventions: OTHER: AmLactin® Rapid Relief
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Bioavailability of IV and SC LBR-101
Status: COMPLETED
Conditions: Bioavailability and Pharmacokinetics
Interventions: BIOLOGICAL: LBR-101 IV|BIOLOGICAL: LBR-101 SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Evaluate Efficacy and Safety of MP1032 in Patients With Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: MP1032|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Back Pain and Spinal Manipulation in Adolescent Scoliosis
Status: COMPLETED
Conditions: Back Pain|Scoliosis
Interventions: OTHER: Spinal Manipulation Therapy|OTHER: Usual Medical Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term Extension Study Evaluating Safety, Tolerability and Immunogenicity Of ACC-001 In Subjects With Mild To Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: BIOLOGICAL: ACC-001(3µg) + QS21|BIOLOGICAL: ACC-001(10µg) + QS21|BIOLOGICAL: ACC-001(30µg) + QS21
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on the Efficacy and Safety of RC48-ADC in the Treatment of Metastatic Castration Resistant Prostate Cancer (mCRPC)
Status: NOT_YET_RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: Disitamab Vedotin（RC48-ADC）
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Medical and Surgical Therapy on Functional Mitral Regurgitation
Status: COMPLETED
Conditions: Cardiovascular Diseases|Heart Diseases|Coronary Disease
Interventions: DRUG: Angiotensin-Converting Enzyme Inhibitors|PROCEDURE: Coronary Artery Bypass Graft|DRUG: Angiotensin Receptor Blockers|DRUG: Spironolactone|DRUG: Aspirin|DRUG: Clopidogrel|PROCEDURE: Surgical Ventricular Restoration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: |Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Efficacy and Safety of GC3110B in Healthy Adults
Status: UNKNOWN
Conditions: Influenza, Human
Interventions: BIOLOGICAL: GC3110B vaccine|BIOLOGICAL: GCFLU Quadrivalent Inj. vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy Study of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Vortioxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intensive Glycemic Control on Infectious Morbidity In Patients With Acute Leukemia
Status: WITHDRAWN
Conditions: Hyperglycemia|Leukemia
Interventions: BIOLOGICAL: insulin glargine recombinant|DRUG: therapeutic insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Occipital Nerve (C2) Stimulation in the Treatment of Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: Occipital Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Effects of Bifidobacterium Longum NCC3001 on Intestinal and Psychological Symptoms in Subjects With Irritable Bowel Syndrome
Status: RECRUITING
Conditions: IBS - Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Bifidobacterium longum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Theophylline as a Treatment for Children With Pseudohypoparathyroidism Type 1a (Albright Hereditary Osteodystrophy)
Status: COMPLETED
Conditions: Pseudohypoparathyroidism Type 1a|Albright Hereditary Osteodystrophy
Interventions: DRUG: Theophylline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Music Therapy-Based Stress Reduction on Bone Marrow Transplant Recipients
Status: COMPLETED
Conditions: Bone Marrow Transplantation|Stem Cell Transplantation
Interventions: BEHAVIORAL: Music therapy-based relaxation/stress reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 10E8.4/iMab Bispecific Antibody in HIV-uninfected and HIV-infected Adults
Status: COMPLETED
Conditions: HIV-1-infection
Interventions: BIOLOGICAL: 10E8.4/iMab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endovascular Treatment of Popliteal Artery - Balloon Angioplasty Versus Primary Stenting
Status: UNKNOWN
Conditions: Popliteal Artery
Interventions: DEVICE: Lifestent|DEVICE: balloon-angioplasty (PTA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Application of Gaseous CO2
Status: UNKNOWN
Conditions: Peripheral Diabetic Neuropathy
Interventions: OTHER: Transcutaneous CO2 application|OTHER: Placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Asian neTwork for Translational Research and Cardiovascular Trials ("ATTRaCT")
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: Cardiovascular Magnetic Resonance Imaging (CMRI)|OTHER: Electrocardiogram (ECG)|OTHER: Blood Sample Collection|OTHER: Clinical Assessment|OTHER: Cardiovascular Ultrasound (CVUS)|OTHER: Cognitive Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Use of a Non-absorbable Marker for the Evaluation of the Gastrointestinal Transit
Status: UNKNOWN
Conditions: Concentration-Time Profiles in Stomach & Intestine.
Interventions: DRUG: Paromomycin Sulfate Fasted State|DRUG: Paromomycin Sulfate Fed State|DRUG: Paromomycin Sulfate w/ domperidone|DRUG: Paromomycin Sulfate w/ loperamide HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bupropion SR Plus Counseling for Smoking Cessation
Status: COMPLETED
Conditions: Tobacco Dependence|Smoking
Interventions: DRUG: Active bupropion + counseling|DRUG: Active bupropion, No counseling|DRUG: Placebo medication + counseling|DRUG: Placebo medication, No counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Liquid Biopsy Evaluation and Repository Development at Princess Margaret
Status: RECRUITING
Conditions: Cancer|Breast Cancer|Lung Cancer|Colon Cancer|Ovarian Cancer|Melanoma|Lymphoma|Leukemia|Mutation|Lynch Syndrome|Cowden Syndrome|BRCA1 Mutation|BRCA2 Mutation|Uterine Cancer|Myeloma|Kidney Cancer|Head and Neck Cancer|Meningioma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reirradiation With Pembrolizumab in Locoregional Inoperable Recurrence or Second Primary Squamous Cell CA of the Head and Neck
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Head and Neck Cancer|Carcinoma, Squamous Cell of Head and Neck
Interventions: RADIATION: Reirradiation|DRUG: MK-3475
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PFOX: Pulmonary Fibrosis Ambulatory Oxygen Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Fibrotic Interstitial Lung Disease
Interventions: OTHER: Ambulatory Oxygen Therapy|OTHER: Sham Ambulatory Oxygen Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sorafenib Tosylate Before and After Donor Bone Marrow Transplant in Treating Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia With FLT3/ITD Mutation
Interventions: PROCEDURE: Bone Marrow Transplantation|DRUG: Sorafenib|DRUG: Sorafenib Tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopically Harvested Omental Free Tissue Autograft to Bypass the Blood Brain Barrier (BBB) in Human Recurrent Glioblastoma Multiforme (rGBM)
Status: SUSPENDED
Conditions: Glioma|Glioma, Malignant|Glioblastoma|Glioblastoma Multiforme|Glioblastoma Multiforme of Brain|GBM|Brain Cancer
Interventions: PROCEDURE: Laparoscopically harvested omental free flap
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT on the Treatment of Menopausal Syndrome With Chinese Medicine
Status: NOT_YET_RECRUITING
Conditions: Menopause
Interventions: DRUG: Modified Guizhi Fuling granules|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Integrated Telemedicine-Home Visitation Program to Increase Outcomes for Children With Medical Complexity
Status: COMPLETED
Conditions: Chronic Disease
Interventions: OTHER: Telemedicine Program|OTHER: Usual Comprehensive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study To Evaluate The Efficacy And Safety Of Betahistine Mesilate In The Treatment Of Patients With Vertigo Caused By Cerebral Infarction In Posterior Circulation
Status: WITHDRAWN
Conditions: Vertigo
Interventions: DRUG: Merislon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of UniRelieverTM Offloading Brace in the Management of Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: UniRelieverTM offloading brace (THUASNE)|DEVICE: Unloader One® X brace (Össur)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Trial of Subcutaneous Versus Subpectoral 2-Staged Implant-Based Breast Reconstruction
Status: COMPLETED
Conditions: Breast Reconstruction Following Mastectomy
Interventions: PROCEDURE: Subcutaneous placement|PROCEDURE: Submuscular placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Opioid Study
Status: COMPLETED
Conditions: Post-operative Pain
Interventions: DRUG: Morphine100|DRUG: Morphine50|DRUG: Fentanyl|DRUG: Hyperbaric Bupivicaine|DRUG: Indomethacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Single Ascending Doses of PF-07081532 in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-07081532|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Metastases-directed Radiotherapy in Addition to Standard Systemic Therapy in Patients With Oligometastatic Breast Cancer
Status: RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: RADIATION: Metastases-directed Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Concussion Aerobic Exercise
Status: WITHDRAWN
Conditions: Concussion, Mild|Mild Traumatic Brain Injury
Interventions: BEHAVIORAL: Exercise Prescription|BEHAVIORAL: Treadmill Test|DEVICE: Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: B-cell Depletion Using the Monoclonal Anti-CD20 Antibody Rituximab in Chronic Fatigue Syndrome
Status: COMPLETED
Conditions: Chronic Fatigue Syndrome|Myalgic Encephalomyelitis
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Handwashing Promotion Program in Three Countries
Status: COMPLETED
Conditions: Infectious Disease|Respiratory Illness|Absenteeism
Interventions: BEHAVIORAL: Procter & Gamble school-based handwashing promotion program|BEHAVIORAL: expanded school-based handwashing promotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial of Oral Valproic Acid for Retinitis Pigmentosa
Status: COMPLETED
Conditions: Retinitis Pigmentosa
Interventions: DRUG: Valproic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vortioxetine for Binge Eating Disorder
Status: COMPLETED
Conditions: Binge Eating Disorder
Interventions: DRUG: Vortioxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interferon Treatment for Patients With Chronic Hepatitis C and End Stage Renal Disease
Status: COMPLETED
Conditions: Chronic Hepatitis C|End Stage Renal Disease
Interventions: DRUG: Peginterferon alfa-2a|DRUG: Interferon alfa-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Roflumilast on Lung Function in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Salmeterol: The EOS Study (BY217/M2-127)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Roflumilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Cyclosporine, a P-Glycoprotein, Breast Cancer Resistance Protein, and Organic-Anion-Transporting Polypeptide Inhibitor, on Pimodivir in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pimodivir|DRUG: Cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Safety, Tolerability and Efficacy of Multiple Subcutaneous Injections of SHR-1209 in Subjects With Hyperlipidemia
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DRUG: SHR-1209|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE Plus)
Status: ACTIVE_NOT_RECRUITING
Conditions: Early Alzheimer´s Disease
Interventions: DRUG: Semaglutide|DRUG: Placebo (semaglutide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: European Novel Motorized Spiral Endoscopy Trial
Status: COMPLETED
Conditions: Disorder of Small Intestine|Gastrointestinal Hemorrhage|Iron Deficiency Anaemia|Crohn's Disease|Small Bowel Tumors|Intestinal Polyposis Syndrome|Coeliac Disease
Interventions: PROCEDURE: motorized spiral enteroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Nicotine for the Prevention of PONV
Status: TERMINATED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Nicotine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of APP13007 for Treatment of Inflammation and Pain After Cataract Surgery
Status: COMPLETED
Conditions: Ocular Inflammation and Pain
Interventions: DRUG: APP13007, 0.05%|DRUG: Matching Vehicle Placebo for APP13007, 0.05%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 12-Month Open-Label Extension Study of Intepirdine (RVT-101) in Subjects With Alzheimer's Disease: MINDSET Extension
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: RVT-101 35 mg tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of Split Influenza Virus Vaccine in Different Age Groups
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: evaluated vaccine|BIOLOGICAL: imported compared vaccine|BIOLOGICAL: domestic compared vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Isoflurane-induced Neuroinflammation in Children With Hydrocephalus
Status: TERMINATED
Conditions: Toxicity|Hydrocephalus
Interventions: DRUG: Isoflurane|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Performance Study of the CardioGard Cannula
Status: COMPLETED
Conditions: Aortic Valve Replacement
Interventions: DEVICE: Aortic Cannulas (CardioGard)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Trial in Squamous Non Small Cell Lung Cancer Subjects Comparing Ipilimumab Versus Placebo in Addition to Paclitaxel and Carboplatin
Status: COMPLETED
Conditions: Lung Cancer - Non Small Cell Squamous
Interventions: DRUG: Ipilimumab|DRUG: Placebo|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Point-of-care Ultrasound and Treatment Disparities for Left Ventricular Hypertrophy
Status: RECRUITING
Conditions: Left Ventricular Hypertrophy
Interventions: BEHAVIORAL: Customized discharge and expedited referral instructions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Abiraterone Acetate Plus Prednisone in Asymptomatic or Mildly Symptomatic Patients With Metastatic Castration-Resistant Prostate Cancer
Status: NO_LONGER_AVAILABLE
Conditions: Prostate Neoplasms
Interventions: DRUG: Abiraterone acetate|DRUG: Prednisone or prednisolone
Study Type: EXPANDED_ACCESS
Clinical trial: A Randomized Trial of Itraconazole in Acute Stages of Allergic Bronchopulmonary Aspergillosis
Status: COMPLETED
Conditions: Allergic Bronchopulmonary Aspergillosis
Interventions: DRUG: Itraconazole|DRUG: Glucocorticoids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate Safety, Immunogenicity of Investigational Flu Vaccine Compared to an Approved Flu Vaccine (QIV) in Children Previously Vaccinated in Trial V118_05
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Adjuvanted Quadrivalent Subunit Influenza Virus Vaccine (aQIV)|BIOLOGICAL: non-adjuvanted Quadrivalent Influenza Vaccine (QIV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Single Dose GW685698X Magnesium Stearate Study In Asthmatic Patients.
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: GW685698X|DRUG: GW685698X containing magnesium stearate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of Individual Versus Group-Level Interventions to Reduce Human Immunodeficiency Virus (HIV)/ Sexually Transmitted Infections (STI) Incidence
Status: NOT_YET_RECRUITING
Conditions: HIV|Other STIs
Interventions: BEHAVIORAL: Dada Kwa Dada (individual-level)|BEHAVIORAL: DADA (group-level)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Expanded Indications in the Adult Cochlear Implant Population
Status: COMPLETED
Conditions: Hearing Loss, Sensorineural
Interventions: DEVICE: MED-EL SYNCHRONY/SYNCHRONY PIN Cochlear Implant System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: INCB001158 Combined With Subcutaneous (SC) Daratumumab, Compared to Daratumumab SC, in Relapsed or Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: DRUG: INCB001158|BIOLOGICAL: Daratumumab SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Contemporary Diagnostics for Patients With Suspected Hospital-Acquired Pneumonia.
Status: COMPLETED
Conditions: Hospital-acquired Pneumonia
Interventions: DIAGNOSTIC_TEST: CT scan|DIAGNOSTIC_TEST: FilmArray Pneumonia Panel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Unstable Distal Radius Fractures With Dorsal Dislocation in Patients Aged 18-64 Years. Volar Locking Plate (VLP) vs Closed Reduction and Percutaenous Pinning (CRPP).
Status: ACTIVE_NOT_RECRUITING
Conditions: Distal Radius Fractures|Wrist Fracture|Colles' Fracture
Interventions: PROCEDURE: Open reduction and volar locking plate and closed reduction and K-wires.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Assess the Efficacy and Safety of SPM 927 (200, 400, and 600mg/Day) in Subjects With Painful Distal Diabetic Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathies
Interventions: DRUG: SPM 927
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Supervised Resistance TRaining amONG Women at Risk of Breast Cancer Related Lymphedema
Status: UNKNOWN
Conditions: Breast Cancer|Physical Activity|Lymphedema of Upper Arm
Interventions: BEHAVIORAL: Resistance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Initiation of Tafolecimab for Patients With Acute Coronary Syndromeundergoing Percutaneous Coronary Intervention in Chinese Population
Status: NOT_YET_RECRUITING
Conditions: Acute Coronary Syndrome|Non ST Segment Elevation Acute Coronary Syndrome
Interventions: DRUG: Tafolecimab|DRUG: Cholesterol Absorption Inhibitor|DRUG: Statin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychotherapy Intervention for Latinos With Advanced Cancer
Status: RECRUITING
Conditions: Solid Tumor|Solid Tumor, Adult|Solid Tumor, Unspecified, Adult
Interventions: BEHAVIORAL: Meaning Centered Psychotherapy for Latinos|BEHAVIORAL: Functional Assessment of Cancer Therapy - Spiritual Well-Being Scale|BEHAVIORAL: Meaning Centered Psychotherapy for Latinos for Waitlist Control Patients|BEHAVIORAL: Pre-assessment questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Exposure of NICU Patients to PVC Plasticizers in At-risk Clinical Situation: Biomonitoring Study From Urinary Samples
Status: UNKNOWN
Conditions: Neonates or Premature Babies|Patient With Urinary Catheter|Patient Hospitalized in NICU
Interventions: OTHER: plasticizers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Proof of Concept Study to Assess the Efficacy, Safety and Pharmacokinetics of LFG316 in Patients With Paroxysmal Nocturnal Hemoglobinuria
Status: COMPLETED
Conditions: Paroxysmal Nocturnal Hemoglobinuria PNH
Interventions: BIOLOGICAL: LFG316|DRUG: LNP023
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study of Altis System With the TVTO Procedure for the Management of Stress Urinary Incontinence in Women
Status: UNKNOWN
Conditions: Genuine Stress Incontinence
Interventions: PROCEDURE: Altis tape|PROCEDURE: TVTO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SupraScapular Cuff Study: Assessing the Effects of Size and Type of Rotator Cuff Tear on Suprascapular Nerve Function
Status: NOT_YET_RECRUITING
Conditions: Orthopedic Disorder
Interventions: RADIATION: MRI|OTHER: Nerve conduction study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Confirmatory Efficacy Trial of a Gluten-Free Diet in a Subgroup of Persons With Schizophrenia Who Have High Levels of IgG Anti-Gliadin Antibodies (AGA IG)
Status: RECRUITING
Conditions: Schizophrenia|Gluten Sensitivity|Schizo Affective Disorder
Interventions: OTHER: Gluten Flour in Protein Shake|OTHER: Rice Flour in Protein Shake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock
Status: ACTIVE_NOT_RECRUITING
Conditions: Shock, Septic
Interventions: DRUG: nangibotide low dose|DRUG: nangibotide high dose|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dextromethorphan as a Novel Non-opioid Adjunctive Agent for Pain Control in Medication Abortion
Status: COMPLETED
Conditions: Abortion in First Trimester
Interventions: DRUG: Dextromethorphan Hydrobromide|DRUG: Avicel PH101 (Microcrystalline Cellulose NF) for Compounding|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity, Safety and Lot to Lot Consistency of Novartis Meningococcal B Recombinant Vaccine When Administered With Routine Infant Vaccinations to Healthy Infants
Status: COMPLETED
Conditions: Serogroup B Meningococcal Meningitis
Interventions: BIOLOGICAL: Serogroup B meningococcal Vaccine lot 1 (rMenB Lot 1)|BIOLOGICAL: Serogroup B meningococcal Vaccine lot 2 (rMenB Lot 2)|BIOLOGICAL: Serogroup B meningococcal Vaccine lot 3 (rMenB Lot 3)|BIOLOGICAL: Infanrix Hexa|BIOLOGICAL: Menjugate|BIOLOGICAL: Prevenar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Migraines Accepted Laser Acupuncture Compared in Blood Test of MMP2 and CGRP: A Single Blind RCT.
Status: NOT_YET_RECRUITING
Conditions: Headache, Migraine
Interventions: DEVICE: Laser Pen|OTHER: Observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing of Bevacizumab, Erlotinib, and Atezolizumab in Combination for Advanced-Stage Kidney Cancer
Status: RECRUITING
Conditions: Hereditary Leiomyomatosis and Renal Cell Carcinoma|Papillary Renal Cell Carcinoma|Renal Cell Carcinoma|Sporadic Papillary Renal Cell Carcinoma|Stage III Renal Cell Cancer AJCC v8|Stage IV Renal Cell Cancer AJCC v8
Interventions: BIOLOGICAL: Atezolizumab|BIOLOGICAL: Bevacizumab|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|PROCEDURE: Computed Tomography with Contrast|DRUG: Erlotinib|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|DRUG: Sodium Fluoride F-18
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Oral Metformin for Intravesical Treatment of Non-muscle-invasive Bladder Cancer
Status: RECRUITING
Conditions: Superficial Bladder Cancer|Bladder Cancer
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Increasing Patients' Engagement in Breast Cancer Surgery Decision-Making
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer Stage 0|Breast Cancer Stage I|Breast Cancer Stage II|Breast Cancer Stage III
Interventions: OTHER: Usual Care|OTHER: Web-based decision aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Stress and Sleep Study
Status: COMPLETED
Conditions: Stress, Psychological|Sleep|Transcutaneous Electric Nerve Stimulation|Vagus Nerve Stimulation|Mindfulness
Interventions: DEVICE: tVNS|BEHAVIORAL: Mindfulness|DEVICE: sham tVNS|OTHER: Number Puzzle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: INsTantenous wavE-Free Ratio-guided PCI Versus Fractional Flow REserve-Guided PCI in rouTine Clinical Practice, Prospective, Multicenter Registry
Status: ACTIVE_NOT_RECRUITING
Conditions: Stable Angina|Non ST Segment Elevation Myocardial Infarction|ST-segment Elevation Myocardial Infarction|Silent Myocardial Ischemia|Unstable Angina
Interventions: OTHER: Instantaneous wave-free ratio measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Posterior Annulus Elevation Technique in Reducing Residual Regurgitation During Mitral Valve Repair in Children
Status: UNKNOWN
Conditions: Mitral Valve Insufficiency
Interventions: PROCEDURE: Posterior Mitral Annulus Elevation Technique|PROCEDURE: Conventional Mitral Valve Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Establishment of a Patient Library in Patients With Pruritus Sine Materia
Status: NOT_YET_RECRUITING
Conditions: Pruritus|Chronic Pruritus|Itch
Interventions: OTHER: Blood samples|OTHER: skin swab sample|OTHER: skin biopsy sample|OTHER: Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Evaluation of the Efficacy of a Dietary Supplement Claiming Anti-aging Properties and UV-protection
Status: NOT_YET_RECRUITING
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: Coriander Seed Oil - Dose 1|DIETARY_SUPPLEMENT: Coriander Seed Oil - Dose 2|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Serum Angiotensin Converting Enzyme and Lysozyme Levels in Patients Non-infectious and Infectious Uveitis
Status: UNKNOWN
Conditions: Sarcoidosis|Tuberculosis
Interventions: OTHER: spectrophotometric assay|OTHER: radial immunodiffusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Silver Nanoparticles for the Prevention of COVID-19
Status: COMPLETED
Conditions: Coronavirus Disease 2019 (COVID-19)
Interventions: DEVICE: Mouthwash and nose rinse with the AgNPs solution|DEVICE: Mouthwashes and nose rinse in a conventional way
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Acupuncture for Pain Control in Patients With Inoperable Pancreatic Cancer
Status: TERMINATED
Conditions: Cancer of Pancreas|Pain
Interventions: PROCEDURE: Electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topotecan Plus Apatinib Versus Topotecan Alone as Second-line Therapy in Small-cell Lung Cancer
Status: UNKNOWN
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Apatinib|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BGB-24714 as Monotherapy and With Combination Therapies in Participants With Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor, Adult
Interventions: DRUG: BGB-24714|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Two Non-surgical Periodontal Treatment Procedures With and Without Interdental Hygiene Devices in Periodontitis Patients: a Longitudinal Prospective Controlled Clinical Trial
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: PROCEDURE: Non-surgical periodontal treatment with interdental hygiene devices|PROCEDURE: Non-surgical periodontal treatment without interdental hygiene devices
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Lomustine/Temozolomide Combination Therapy vs. Standard Therapy for Glioblastoma Patients
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: Temozolomide and lomustine|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Cognitive and Cerebral Blood Flow Effects of Resveratrol
Status: COMPLETED
Conditions: Cognitive and Cerebral Blood Flow Effects of Resveratrol
Interventions: DIETARY_SUPPLEMENT: Trans- resveratrol|OTHER: Placebo (silica)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE