pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Sleep Well: Digital Insomnia Treatment Program For Physicians
Status: COMPLETED
Conditions: Sleep Disturbance|Insomnia|Stress, Psychological|Anxiety|Burnout, Professional
Interventions: BEHAVIORAL: Sleep Healthy Using the Internet (SHUT-i)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Extension Study in Patients With Erythropoietic Protoporphyria (EPP)
Status: COMPLETED
Conditions: Erythropoietic Protoporphyria
Interventions: DRUG: Afamelanotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Tislelizumab Combined With Nab-Paclitaxel as First Line Treatment for Patients of Triple-negative Breast Cancer(TNBC) With Bone Metastasis
Status: NOT_YET_RECRUITING
Conditions: Triple-negative Breast Cancer|Bone Metastases
Interventions: DRUG: Tislelizumab + Nab-Paclitaxel|OTHER: Bone Targeted Agents
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women
Status: COMPLETED
Conditions: Menopause|Aging
Interventions: DRUG: KUVAN|DRUG: Placebo|DRUG: Cetrotide|DRUG: Climara|DRUG: Placebo transdermal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Twice Daily Application of LEO 124249 Ointment 30 mg/g for 12 Weeks on Eyebrow Alopecia Areata.
Status: TERMINATED
Conditions: Alopecia Areata
Interventions: DRUG: LEO 124249|OTHER: Ointment vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of LB80380 in the Patients With Lamivudine-Refractory Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: LB80380
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glofit and Obin in Follicular Lymphoma and Marginal Zone Lymphoma
Status: RECRUITING
Conditions: Follicular Lymphoma|Marginal Zone Lymphoma|Indolent Non-hodgkin Lymphoma
Interventions: DRUG: Obinutuzumab|DRUG: Glofitamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Fibula Free-flap MR With or Without PVP in Patients With OOPC
Status: RECRUITING
Conditions: Oropharynx Squamous Cell Carcinoma|Oral Cavity Squamous Cell Carcinoma
Interventions: DEVICE: Mandibular Reconstruction (MR) with Preoperative Virtual Planning (PVP).|DEVICE: Conventional Mandibular Reconstruction (MR without PVP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preoperative Self-managed Respiratory Therapy for Reduction of Postoperative Pulmonary Complications
Status: WITHDRAWN
Conditions: Postoperative Respiratory Complication
Interventions: DEVICE: AirLife 4000 cc incentive spirometry device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: T-DM1 and Palbociclib for Metastatic HER2 Breast Cancer
Status: COMPLETED
Conditions: HER2-positive Breast Cancer|Breast Cancer|Breast Cancer Stage|Recurrent Breast Cancer|Metastatic Breast Cancer|HER2 Positive Breast Carcinoma
Interventions: DRUG: Palbociclib|DRUG: T-DM1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction of Puberty With 17-beta Estradiol in Girls With Turner Syndrome
Status: COMPLETED
Conditions: Genetic Disorder|Turner Syndrome
Interventions: DRUG: 17-beta estradiol|DRUG: 17-beta estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diastolic Dysfunction in Patients With Type 2 Diabetes Mellitus
Status: TERMINATED
Conditions: Diabetes Mellitus Type 2 (T2DM)|Left Ventricular Diastolic Dysfunction
Interventions: DRUG: Linagliptin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Validation Study of the Malay Version of 3D-CAM
Status: COMPLETED
Conditions: Postoperative Delirium|Diagnosis, Psychiatric
Interventions: DIAGNOSTIC_TEST: Malay 3D-CAM diagnostic tool 1|DIAGNOSTIC_TEST: Malay 3D-CAM Diagnostic tool 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Role of Inhalations of Tranexamic Acid in Patients With Hemoptysis
Status: UNKNOWN
Conditions: Hemoptisis
Interventions: DRUG: tranexamic acid|DRUG: tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Minimally-invasive Stabilization of Pelvic Metastases With Photodynamic Nails: A Multi-center Prospective Study of Functional Outcome
Status: RECRUITING
Conditions: Pelvic Metastasis
Interventions: PROCEDURE: Photodynamic nails
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Evaluation of Investigational Contact Lenses
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: Etafilcon A Design 1 (Test 1)|DEVICE: Etafilcon A Design 2 (Test 2)|DEVICE: Etafilcon A (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Netazepide on Omeprazole-induced Changes in Chromogranin A and Gastrin
Status: COMPLETED
Conditions: ECL-cell Hyperplasia|Parietal-cell Hyperplasia|Rebound Hyperacidity|Dyspepsia
Interventions: DRUG: netazepide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Intervention for the Reduction of Breast Cancer Risk in Normal Weight Women
Status: RECRUITING
Conditions: Breast Carcinoma
Interventions: OTHER: Aerobic Exercise|OTHER: Dietary Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|OTHER: Resistance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A 6-week Dose Ranging Study of CHF 5259 pMDI in Subjects With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: COPD|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: CHF 5259|DRUG: Placebo|DRUG: Tiotropium Bromide 18 µg Inhalation Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Compound Edaravone Injection for Acute Ischemic Stroke
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Compound Edaravone Injection|DRUG: Edaravone Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glucose Monitoring After Acute Myocardial Infarct in People With Diabetes
Status: RECRUITING
Conditions: Type 2 Diabetes|Acute Myocardial Infarction|Acute Myocardial Infarction With ST Elevation|Diabetes Complications
Interventions: DEVICE: Dexcom ONE Continuous Glucose Monitoring System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis
Status: RECRUITING
Conditions: Atopic Dermatitis|Nature, Human|Microbial Colonization|Immune System and Related Disorders
Interventions: BIOLOGICAL: Microbial intervention|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Problem Solving Therapy for Prostate Cancer Spousal Caregivers
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BEHAVIORAL: Problem-Solving Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acute Effects of Motor Imagery and Physical Exercise on Tongue Strength and Pain Threshold in Healthy Adults
Status: UNKNOWN
Conditions: Motor Imagery Training|Physical Exercise|Orofacial Exercise
Interventions: BEHAVIORAL: Physical Exercise|BEHAVIORAL: Kinesthetic Motor Imagery Exercises|BEHAVIORAL: Visual Motor Imagery Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-Intensity Focused Ultrasound For Insular Neuromodulation in Chronic Pain
Status: RECRUITING
Conditions: Fibromyalgia|Complex Regional Pain Syndromes|Chronic Pain
Interventions: DEVICE: Low-intensity Focused Ultrasound (LIFU)|DEVICE: Sham Low-intensity focused ultrasound (LIFU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A National Phase IV Study With Ipilimumab for Patients With Advanced Malignant Melanoma.
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Melanoma
Interventions: PROCEDURE: Blood sampling for Pre-existing immunity|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of PC 6 "Neiguan" With Conventional Acupuncture to Prevent PONV After Laparoscopic Cholecystectomy.
Status: UNKNOWN
Conditions: Cholecystitis|Vomiting|Nausea
Interventions: OTHER: stimulation|OTHER: no stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating Gemtuzumab Ozogamicin in Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Gemtuzumab Ozogamicin|DRUG: cytarabine.
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effect of Virtual Reality on Anxiety and Fatigue in Women With Breast Cancer Receiving Adjuvant Chemotherapy
Status: COMPLETED
Conditions: Breast Cancer Female|Anxiety|Fatigue
Interventions: OTHER: Virtual Reality Glasses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Recovery Housing and Drug Abuse Treatment Outcome
Status: COMPLETED
Conditions: Mental and Behavioral Disorders Due to Use of Cocaine: Harmful Use|Opiate Addiction
Interventions: BEHAVIORAL: Recovery Housing plus Counseling|BEHAVIORAL: Usual Care Referral|BEHAVIORAL: Recovery Housing Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin
Status: RECRUITING
Conditions: Traumatic Brain Injury|Critical Illness|Sleep
Interventions: DRUG: melatonin|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Efficacy and Safety of CTL019 in Pediatric ALL Patients
Status: COMPLETED
Conditions: B-cell Acute Lymphoblastic Leukemia|Relapsed B-cell Acute Lymphoblastic Leukemia|Refractory B-cell Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: CTL019 T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Fresh Fermented Dairy Drink Product Consumption on Antibiotic Associated Diarrhea and Gastro-Intestinal Disorders
Status: TERMINATED
Conditions: Antibiotic-Associated Diarrhea
Interventions: OTHER: 1 - Fermented dairy drink|OTHER: 2 - Acidified dairy drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety of Fondaparinux as Routine VTE Prophylaxis in Medical ICU Patients
Status: TERMINATED
Conditions: Venous Thromboembolism
Interventions: DRUG: Fondaparinux|DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Gemcitabine/Irinotecan/ZD1839 vs Paclitaxel/Carboplatin/Etoposide/ZD1839 in Carcinoma of Unknown Primary Site
Status: COMPLETED
Conditions: Neoplasms, Unknown Primary
Interventions: DRUG: Etoposide|DRUG: Gemcitabine|DRUG: Irinotecan|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet-based Intervention for Enhancing the Psychological Well-being of Elderly Caregivers
Status: COMPLETED
Conditions: Depressive Symptoms|Psychological Distress|Quality of Life
Interventions: BEHAVIORAL: Internet-based ACT intervention|BEHAVIORAL: Standardized rehabilitation|BEHAVIORAL: Support by voluntary caregiver associations
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Macroscopic and Molecular Changes in Knee Muscular-tendon Unit in Response to Acute Resistant Load
Status: UNKNOWN
Conditions: Quadriceps Muscle
Interventions: OTHER: Acute resistant load exercises|BEHAVIORAL: Background Questionnaire|OTHER: Pain Questionnaire|GENETIC: DNA and RNA test|DIAGNOSTIC_TEST: Ultrasound|DIAGNOSTIC_TEST: Percutaneous Needle Core Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Modafinil, Sleep Architecture and Cocaine Relapse
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: Modafinil|BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enteral Fish Oil is Superior to Ursodeoxycholic Acid (UDCA) and Placebo for the Treatment of Cholestasis in Infants
Status: WITHDRAWN
Conditions: Cholestasis|Liver Disease
Interventions: DRUG: Enteral fish oil|DRUG: Ursodeoxycholic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Absorption, Metabolism, and Excretion of a Single Dose of Ferriprox® in Patients With Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: single 1500 mg dose of Ferriprox
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Asthma in Central Texas Project
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: Asthma in-school class|BEHAVIORAL: Asthma Day Camp|BEHAVIORAL: Health Promotion in-school class
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Effects and Interactions of Liquorice and Grapefruit on Glucocorticoid Replacement Therapy in Addison's Disease
Status: COMPLETED
Conditions: Addison Disease
Interventions: DIETARY_SUPPLEMENT: Liquorice|DIETARY_SUPPLEMENT: Grapefruit Juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial Investigating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Subcutaneous NNC0123-0338 in Healthy Subjects and in Subjects With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Healthy|Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: Insulin 338|DRUG: placebo|DRUG: Insulin 338|DRUG: insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Astigmatism Management With Iris-registration Guided Corneal Relaxing Incisions or Toric IOLs During Cataract Surgery
Status: UNKNOWN
Conditions: Astigmatism|Cataract
Interventions: PROCEDURE: Femtosecond laser assisted cataract surgery with astigmatism management
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Androgen Suppression Combined With Elective Nodal and Dose Escalated Radiation Therapy
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: PROCEDURE: Androgen suppression, radiotherapy|PROCEDURE: Androgen suppression, radiotherapy, iodine 125 brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Intravenous Lidocaine Infusion Versus Placebo for Rib Fracture Analgesia
Status: TERMINATED
Conditions: Rib Fractures
Interventions: DRUG: Saline infusion|DRUG: Lidocaine infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy, Safety, and Tolerability of RGH-706 in Prader-Willi Syndrome
Status: COMPLETED
Conditions: Prader-Willi Syndrome
Interventions: DRUG: RGH-706|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Azacitidine and Arsenic Trioxide in Treating Patients With Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia
Status: TERMINATED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: arsenic trioxide|DRUG: azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Alendronate Sodium Tablets 70 mg of Dr. Reddy's Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Alendronate Sodium Tablets, 70 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transfusion-Associated Circulatory Overload Best Eliminated With Lasix
Status: COMPLETED
Conditions: Transfusion-associated Circulatory Overload
Interventions: DRUG: Furosemide|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Rotational Atherectomy (RA) in Coronary Dissection
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Immediate rotational atherectomy (RA)|PROCEDURE: Delayed rotational atherectomy (RA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab and Lenalidomide in Treating Patients With Relapsed or Refractory Non-Hodgkin or Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Grade 3a Follicular Lymphoma|Recurrent Burkitt Lymphoma|Recurrent Diffuse Large B-Cell Lymphoma|Recurrent Follicular Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Lymphoplasmacytic Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Waldenstrom Macroglobulinemia|Refractory Burkitt Lymphoma|Refractory Diffuse Large B-Cell Lymphoma|Refractory Follicular Lymphoma|Refractory Lymphoplasmacytic Lymphoma|Refractory Mantle Cell Lymphoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Lenalidomide|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual PREHAB Study for Patients Undergoing TAVI
Status: RECRUITING
Conditions: Cardiovascular Diseases in Old Age|Frailty|TAVI
Interventions: BEHAVIORAL: Virtual PREHAB|BEHAVIORAL: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy of Nintedanib+Tocilizumab in Patients With Systemic Sclerosis and Interstitial Lung Disease
Status: NOT_YET_RECRUITING
Conditions: Systemic Sclerosis|Interstitial Lung Disease
Interventions: DRUG: Tocilizumab|DRUG: Nintedanib|DRUG: Standard therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Cerebral Blood Flow and Cognition in Patients With Cerebral Small Vessel Disease. The ETLAS-2 Trial
Status: RECRUITING
Conditions: Cerebral Small Vessel Diseases|Stroke, Ischemic
Interventions: DRUG: Tadalafil 20 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Diclofenac as a KMO Inhibitor
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use Disorder
Interventions: DRUG: Diclofenac|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Improvement of Gait by Spinal Stimulation in Patients With Postoperative Chronic Lumbosciatalgia: Pilot Study (GaitStim)
Status: NOT_YET_RECRUITING
Conditions: Failed Back Surgery Syndrome
Interventions: OTHER: walking quantified analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bicalutamide and Raloxifene Hydrochloride in Treating Patients With Prostate Cancer Undergoing Surgery
Status: WITHDRAWN
Conditions: Stage I Prostate Adenocarcinoma|Stage II Prostate Adenocarcinoma
Interventions: DRUG: Bicalutamide|OTHER: Laboratory Biomarker Analysis|OTHER: Questionnaire Administration|DRUG: Raloxifene Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Immune Activation and Tolerance in Celiac Disease During Gluten Challenge
Status: COMPLETED
Conditions: Celiac Disease
Interventions: DIETARY_SUPPLEMENT: Gluten
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Phase 1/2 Crossover Study to Assess EXP039 for Myopia or Hyperopia
Status: UNKNOWN
Conditions: Hyperopia|Myopia
Interventions: DRUG: 1% EXP039|OTHER: Saline control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Mechanism of Acupuncture Treatment in Patients With Subjective Cognitive Decline
Status: UNKNOWN
Conditions: Subjective Cognitive Decline|Subjective Cognitive Complaint
Interventions: DEVICE: Acupuncture group|DEVICE: Sham acupuncture group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interleukin-2 With Sorafenib (BAY 43-9006) for Unresectable or Metastatic Clear Cell Renal Carcinoma (RCC) and Metastatic Melanoma
Status: COMPLETED
Conditions: Renal Cancer|Melanoma
Interventions: DRUG: Aldesleukin|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis
Status: UNKNOWN
Conditions: Tuberculous Meningitis
Interventions: DRUG: Dexamethasone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HANGZHOU Solution in Bicuspid AS Undergoing TAVR
Status: RECRUITING
Conditions: Aortic Stenosis|Aortic Stenosis With Bicuspid Valve
Interventions: DEVICE: TAVR with Venus A plus using supra-annular sizing and THV implantation technique (Hangzhou solution)|DEVICE: TAVR with Venus A plus using annular sizing and THV implantation technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: European Registry for Hemadsorption in Sepsis With the Seraph Filter
Status: RECRUITING
Conditions: Sepsis|Acute Respiratory Distress Syndrome|Infections - Pathogen Unspecified|Disease|Critical Illness|Multi Organ Failure|Systemic Inflammatory Response Syndrome
Interventions: DEVICE: Hemoperfusion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Berzosertib + Topotecan in Relapsed Platinum-Resistant Small-Cell Lung Cancer (DDRiver SCLC 250)
Status: COMPLETED
Conditions: Small-cell Lung Cancer
Interventions: DRUG: Berzosertib|DRUG: Berzosertib|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Multi Centre Study to Assess the Safety and Performance of Two Prototype One Piece Pouches in Subjects With an Ileostomy
Status: TERMINATED
Conditions: Ileostomy
Interventions: DEVICE: Enhanced one piece drainable pouch with Type A mouldable adhesive|DEVICE: Enhanced one piece drainable pouch with Type B mouldable adhesive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Montelukast Therapy on Clinical Course, Pulmonary Function, and Mortality in Patients With COVID-19
Status: UNKNOWN
Conditions: COVID-19 Pneumonia
Interventions: DRUG: Standart treatment group|DRUG: Montelukast sodium 10 mg treatment|DRUG: Montelukast sodium 20 mg treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evidence-Based Tobacco Cessation Strategies in Patients With Cancer
Status: COMPLETED
Conditions: Malignant Neoplasm
Interventions: BEHAVIORAL: smoking cessation intervention|OTHER: survey administration|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Genomic Directed Salvage Chemotherapy With Either Liposomal Doxorubicin Or Topotecan
Status: TERMINATED
Conditions: Ovarian Cancer
Interventions: DRUG: Liposomal Doxorubicin|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 12-Week Efficacy and Safety Study of Ibodutant in Women With Irritable Bowel Syndrome With Diarrhea (IBS-D)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Diarrhea
Interventions: DRUG: Ibodutant 10 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2)
Status: ACTIVE_NOT_RECRUITING
Conditions: Sedation
Interventions: DRUG: Isoflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mangafodipir as an Adjunct to FOLFOX6 Chemotherapy in Colon Cancer Stage Dukes' C
Status: COMPLETED
Conditions: Chemotherapy|Colon Cancer
Interventions: DRUG: Mangafodipir|DRUG: Placebo treatment (0.9% NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Assessing Effects of Heparin Priming and Pass Number on Tissue Quality of Fine Needle Biopsies
Status: TERMINATED
Conditions: Pancreas|Mass Lesion
Interventions: COMBINATION_PRODUCT: Heparin will be used for needle priming (BD PosiFlush™ Pre-Filled Heparin Lock Flush Syringe)|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tolerization Reduces Intolerance to Pegloticase and Prolongs the Urate Lowering Effect
Status: COMPLETED
Conditions: Gout
Interventions: BIOLOGICAL: Pegloticase|DRUG: Azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Urine-based Molecular Testing vs Cystoscopy for Surveillance of Nonmuscle Invasive Bladder Cancer (NMIBC)
Status: RECRUITING
Conditions: Non-muscle Invasive Bladder Cancer
Interventions: DIAGNOSTIC_TEST: CxBladder Monitor|DIAGNOSTIC_TEST: Cystoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Study to Assess the Safety and Effectiveness of Plant Based Biotin in Healthy Human Subjects With Thin, Dry, and Brittle Hair
Status: COMPLETED
Conditions: Hair Thinning|Hair Brittle|Dry Hair
Interventions: DIETARY_SUPPLEMENT: SesZen-Bio™|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Arsucam® (Artesunate + Amiodaquine) Efficacy and TOLerance
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Artesunate|DRUG: Amodiaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1b/2 Study to Evaluate ABT-101 in Solid Tumor and NSCLC Patients
Status: RECRUITING
Conditions: Advanced Solid Tumor|Non Small Cell Lung Cancer|HER2 Mutations
Interventions: DRUG: ABT-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of SCB-420 in Subjects With Neovascular Age-related Macular Degeneration
Status: WITHDRAWN
Conditions: Wet Age-related Macular Degeneration
Interventions: DRUG: SCB-420|DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Stribild Versus Atripla in Human Immunodeficiency Virus, Type 1 (HIV-1) Infected, Antiretroviral Treatment-Naive Adults
Status: COMPLETED
Conditions: HIV|HIV Infections
Interventions: DRUG: Stribild|DRUG: Atripla|DRUG: Stribild Placebo|DRUG: Atripla Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Cognitive-Behavioral Therapy for Insomnia in Spanish Speaking Latinas/os (Dormir Mejor Study)
Status: COMPLETED
Conditions: Insomnia
Interventions: BEHAVIORAL: Digital cognitive behavioral therapy for insomnia (CBT-I) program|BEHAVIORAL: Minimally Enhanced Usual Care (mEUC)|DEVICE: Somryst (culturally adapted)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Progesterone for Prevention of Preterm Birth
Status: COMPLETED
Conditions: Preterm Birth
Interventions: DRUG: oral micronized progesterone|DRUG: Identical Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Panitumumab and Pembrolizumab in Combination With Neoadjuvant Chemotherapy for the Treatment of Stage III-IV Triple Negative Breast Cancer
Status: WITHDRAWN
Conditions: Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Breast Inflammatory Carcinoma|Invasive Breast Carcinoma|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8|Prognostic Stage IV Breast Cancer AJCC v8|Triple-Negative Breast Carcinoma
Interventions: DRUG: Carboplatin|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Paclitaxel|BIOLOGICAL: Panitumumab|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: [18F]Fluoro-PEG-folate PET/CT Imaging in Epithelial Ovarian Cancer
Status: TERMINATED
Conditions: Epithelial Ovarian Cancer
Interventions: DIAGNOSTIC_TEST: [18F]fluoro-PEG-folate PET/CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect Of PF-06305591 On Capsaicin And Capsaicin/Heat-Induced Neurogenic Flare
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06305591|OTHER: Capsaicin challenge|DRUG: Placebo|OTHER: Capsaicin challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Injection of Day 2 Embryo Culture Supernatant Into the Uterine Cavity Didn't Improve Implantation and Pregnancy Rates
Status: COMPLETED
Conditions: Infertility|In Vitro Fertilization
Interventions: PROCEDURE: uterine cavity injection of day 2 embryo culture supernatant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Nutrient Blend in Improving Neurocognitive and Behavioral Outcomes in Infants: a Randomized, Controlled, Intervention Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Infant Nutrition|Cognitive Development
Interventions: OTHER: Experimental formula|OTHER: Control Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis
Status: COMPLETED
Conditions: Perforated Appendicitis
Interventions: DRUG: IV tylenol|DRUG: No IV tylenol|DRUG: Ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Efficacy and Safety of VX-548 for Painful Lumbosacral Radiculopathy (PLSR)
Status: ACTIVE_NOT_RECRUITING
Conditions: Painful Lumbosacral Radiculopathy
Interventions: DRUG: VX-548|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Trial of Apalutamide Plus Abiraterone Acetate, Docetaxel, and Prednisone in Patients With mCRPC
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer Metastatic
Interventions: DRUG: Apalutamide|DRUG: Abiraterone acetate|DRUG: Docetaxel|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Doxycycline Monohydrate Tablets Under Fed Conditions
Status: COMPLETED
Conditions: To Determine Bioequivalence Under Fed Conditions
Interventions: DRUG: doxycycline monohydrate|DRUG: doxycycline monohydrate|DRUG: doxycycline monohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prostate Cancer Detection Rates of Standard Transrectal Prostate Biopsy and MR-guided Fusion Transrectal Prostate Biopsy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: mpMR guided MR-US fusion transrectal prostate biopsy|PROCEDURE: 12 core standard transrectal prostate biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Secondary Cytoreductive Surgery in Platinum-resistant Recurrent Ovarian Cancers
Status: WITHDRAWN
Conditions: Ovarian Cancer|Recurrent Ovarian Carcinoma
Interventions: PROCEDURE: secondary cytoreductive surgery|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Heart Rate on Central Blood Pressure in Sick Sinus Syndrome Patients With a Permanent Cardiac Pacemaker
Status: COMPLETED
Conditions: Aortic Blood Pressure
Interventions: DEVICE: AAI 40 bpm|DEVICE: AAI 60 bpm|DEVICE: AAI 90 bpm|DRUG: Atenolol Pill|DRUG: Nebivolol Pill|DRUG: Ivabradine Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Acceptance and Commitment Therapy-based Lifestyle Counselling Programme for Early Psychosis on Physical Activity
Status: COMPLETED
Conditions: Schizophrenia Spectrum and Other Psychotic Disorders
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy-based lifestyle counselling programme|BEHAVIORAL: Healthy lifestyle talk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alerta Alcohol. Web-based Computer-tailored Intervention for Binge-drinking Prevention in Spanish Adolescents
Status: COMPLETED
Conditions: Alcohol Drinking|Binge Drinking|Adolescent Behavior
Interventions: BEHAVIORAL: Alerta Alcohol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Use of Preemptive Pudendal Nerve Block Prior to Hydrodistention for the Treatment of Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS)
Status: TERMINATED
Conditions: Interstitial Cystitis|Painful Bladder Syndrome
Interventions: DRUG: Lidocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Beat-to-Beat ClearSight Blood Pressure Monitoring
Status: COMPLETED
Conditions: Hypotension
Interventions: PROCEDURE: Orthopedic, urologic or general surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Antimicrobial Durations Treatment of Infections Associated With Osteosynthesis Material
Status: RECRUITING
Conditions: Infections
Interventions: COMBINATION_PRODUCT: Short course of antibiotherapy|COMBINATION_PRODUCT: Long course of antibiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerability And Efficacy Of High Dose Escitalopram In The Treatment Of Patients Suffering From Schizophrenia And Obsessive-Compulsive Disorder (OCD) - An Open Label Study
Status: UNKNOWN
Conditions: OCD|Schizophrenia
Interventions: DRUG: Escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medical Treatment of Endometriosis-Associated Pelvic Pain
Status: COMPLETED
Conditions: Endometriosis|Pelvic Pain
Interventions: DRUG: Oral Contraceptive|DRUG: Depot-Leuprolide/Norethindrone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of ACT for Problematic Chemsex
Status: NOT_YET_RECRUITING
Conditions: Hypersexuality|Compulsive Sexual Behavior|Sexualized Drug Use (Chemsex)
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy (ACT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Role of Coronary CTA on Lipid Management and Risk Factors Control in an Asymptomatic Chinese Population
Status: RECRUITING
Conditions: Statin|Cardiovascular Risk Factors|Primary Prevention|Adherence, Medication
Interventions: DIAGNOSTIC_TEST: Coronary Computed Tomography Angiography|OTHER: Traditional cardiovascular risk stratification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ejaculation Preserving Photoselective Vaporization Versus Plasma Kinetic Vaporization Versus Transurethral Resection Of The Prostate: A RCT
Status: UNKNOWN
Conditions: Ejaculation Abnormal|BPH With Urinary Obstruction|Prostatic Hyperplasia|Prostate Disease|Prostate Obstruction
Interventions: PROCEDURE: Ejaculation Preserving Photoselective Vaporization|PROCEDURE: Ejaculation Preserving Plasma Kinetic Vaporization|PROCEDURE: Ejaculation Preserving Transurethral Resection Of The Prostate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paracervical Block for Pain Associated With Laminaria Insertion
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Paracervical Block with lidocaine|DRUG: Sham paracervical block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Diaphragmatic Breathing Exercise on Symptom Severity, Sleep Quality and Anxiety in CABG Patients.
Status: RECRUITING
Conditions: Coronary Artery|Anxiety|Symptom|Sleep
Interventions: BEHAVIORAL: diaphragmatic breathing exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: To Assess the Efficacy and Safety of Adalimumab in Subjects With Moderate to Severe Hidradenitis Suppurativa
Status: COMPLETED
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Probiotics Regulating miRNA in H. Pylori-induced Wnt/β-catenin Gastric Carcinogenesis.
Status: RECRUITING
Conditions: H. Pylori Infection|Carcinogenesis
Interventions: OTHER: probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vytorin on Carotid Intima-media Thickness and Overall Rigidity
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DRUG: ezetimibe (+) simvastatin|DRUG: simvastatin|DRUG: pravastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bioavailability of Eszopiclone 3.0 mg With Regards to Reference Product
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Eszopiclone 3mg Test Drug T-1 Coated Tablets|DRUG: Eszopiclone 3mg Test Drug T-2 Coated Tablets|DRUG: Eszopiclone 3mg Reference Product Coated Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Hesperetin in Combination With Sucrose on Energy Metabolism
Status: COMPLETED
Conditions: Blood Glucose Fluctuations|Hunger
Interventions: OTHER: Sucrose|DRUG: Hesperetin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Drug Interaction Study of SLM0807 and HKB0701 in Healthy Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Period I : SLM0807, Period II : HKB0701 and SLM0807|DRUG: Period I : HKB0710 and SLM0807, Period II : SLM0807
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Bromelain Supplement in Patients With Ulcerative Colitis
Status: RECRUITING
Conditions: Ulcerative Colitis|Primary Sclerosing Cholangitis
Interventions: DIETARY_SUPPLEMENT: Bromlein|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Osteopathic Visceral Manipulation on the Autonomic Nervous System, Balance and Gastrointestinal Disturbances in Individuals With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: Intervention Protocol|OTHER: Sham Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Open Randomized Comparison of 566C80 and Pentamidine Isethionate for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients Who Are Intolerant of Trimethoprim / Sulfamethoxazole
Status: COMPLETED
Conditions: Pneumonia, Pneumocystis Carinii|HIV Infections
Interventions: DRUG: Atovaquone|DRUG: Pentamidine isethionate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT