pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphobkastic Leukemia
Interventions: DRUG: Vincristine|DRUG: Daunorubicin|DRUG: Prednisone|DRUG: L-asparaginase|DRUG: Ciclophosphamide|DRUG: Metotrexate|DRUG: ARA-C|DRUG: Hidrocortisone|DRUG: Mercaptopurine|DRUG: VP-16|DRUG: Dexametasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ontogeny of MAIT Cells in Neonates and Hematopoietic Stem Cell Transplant Recipients
Status: COMPLETED
Conditions: Term and Preterm Neonates (24-41 Weeks Gestational Age)|Hematopoietic Stem Cell Transplant Recipient Children
Interventions: OTHER: Tubes fund recovery blood count|OTHER: the rest of the blood test and stool sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease
Status: NOT_YET_RECRUITING
Conditions: Ulcerative Colitis|Crohn's Disease
Interventions: DRUG: Vedolizumab IV|DRUG: Vedolizumab SC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resistance Training in Intradialysis Patients
Status: UNKNOWN
Conditions: Dialysis|End Stage Renal Disease
Interventions: BEHAVIORAL: Progressive Resistance Exercise Training|BEHAVIORAL: Unstructured Nonprogressive resistance exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase II Study of KW2871 Combined With High Dose Interferon-α2b in Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Metastatic Melanoma|Cutaneous Melanoma
Interventions: DRUG: HDI|DRUG: KW2871|DRUG: KW2871|DRUG: KW2871
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaginal Native Tissues Repair for Pelvic Organ Prolapse
Status: RECRUITING
Conditions: Prolapse, Vaginal
Interventions: PROCEDURE: Anterior colporraphy|PROCEDURE: vaginal patch plastron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Monitor the Incidence of Congenital Malformations in Infants of Women Who Have Been Treated With Ganirelix (Orgalutran®)(Study 38644)(P05966)(COMPLETED)
Status: COMPLETED
Conditions: Pregnancy|Neonates
Interventions: DRUG: ganirelix|DRUG: GnRH agonist
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase III Study of MR-Guided Focused Ultrasound Surgery for the Treatment of Uterine Fibroids Compared to Myomectomy
Status: RECRUITING
Conditions: Uterine Fibroids
Interventions: PROCEDURE: Magnetic Resonance Imaging-controlled high-focussed ultrasound therapy|PROCEDURE: Myomectomy (laparoscopic or open surgical)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Growth and Development Study of Alglucosidase Alfa
Status: COMPLETED
Conditions: Pompe Disease|Glycogen Storage Disease Type II (GSD-II)|Acid Maltase Deficiency Disease
Interventions: BIOLOGICAL: alglucosidase alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Concurrent Chemoradiation With Weekly Docetaxel/Cisplatin for Resectable IIIA-N2 NSCLC
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: docetaxel/cisplatin|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study to Evaluate the Effect of HSP-130, US-approved Neulasta and EU-approved Neulasta in Healthy Participants
Status: COMPLETED
Conditions: Neutropenia
Interventions: DRUG: HSP-130|DRUG: US-approved Neulasta|DRUG: EU-approved Neulasta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Short-term And Longer-term Cognitive Impact Of Neurochecks
Status: NOT_YET_RECRUITING
Conditions: Intracerebral Hemorrhage
Interventions: BEHAVIORAL: Frequency of neurochecks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Anteroposterior Versus Anterolateral Electrode Position for Electrical Cardioversion of Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation|Atrial Flutter
Interventions: OTHER: Anterolateral electrode position|OTHER: Anteroposterior electrode position|OTHER: Manual pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and the Efficacy of a Sublingual Administration of Flumazenil to Reverse the Effect of Hypnotic Drugs in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Flumazenil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Suicidal Ideation in the Emergency Department Using Nitrous Oxide
Status: NOT_YET_RECRUITING
Conditions: Suicidal Ideation|Emergency Psychiatric|Nitrous Oxide
Interventions: DRUG: Nitrous oxide|DRUG: Medical air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Association of Telephone Head Tilt With Cervical, Thoracic, and Lumbar Spine Mobility and Disorders in Young Adults
Status: RECRUITING
Conditions: Forward Head Posture
Interventions: OTHER: To assess telephone head tilt and cervical, thoracic, and lumbar spine mobility and disturbances.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Capsaicin-induced Pain on Homeostatic Plasticity in Healthy Human Participants
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: Capsaicin Topical - alone|DRUG: Placebo - alone|DRUG: Capsaicin Topical - ice|DRUG: Placebo - ice
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Evaluation of Different Bulk-fill Composite Restorations on Posterior Teeth
Status: ACTIVE_NOT_RECRUITING
Conditions: Carious Teeth
Interventions: PROCEDURE: 4 different bulk-fill composite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Intervention Plus Emotion Regulation Group Intervention Impact on Women's Cardiovascular Risk Reduction
Status: ENROLLING_BY_INVITATION
Conditions: Cardiovascular Diseases|Lifestyle Risk Reduction
Interventions: BEHAVIORAL: Lifestyle Plus Emotional Regulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Barley on Glucose Control
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: 0g barley β-glucan no fibre|DIETARY_SUPPLEMENT: 2g barley β-glucan|DIETARY_SUPPLEMENT: 4g barley β-glucan|DIETARY_SUPPLEMENT: 6g barley β-glucan|DIETARY_SUPPLEMENT: 0g barley β-glucan with fibre
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Can Exenatide Prevent Increase in EGP in Response to Dapagliflozin-induced Increase in Glucosuria
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo|DRUG: Exenatide|DRUG: Dapagliflozin|DRUG: Exenatide and Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Efficacy and Safety Study of Sirukumab in Participants With Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Sirukumab 50 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Relative Bioavailability Study of BMS-986195 in Healthy Subjects
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: BMS-986195|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Polygonatum Sibiricum on Sleep Quality Improvement
Status: COMPLETED
Conditions: Healthy Adults With Subjective Sleep Complaints
Interventions: DIETARY_SUPPLEMENT: Polygonatum sibiricum|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sorafenib in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia
Interventions: DRUG: sorafenib tosylate|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selumetinib and Erlotinib Hydrochloride in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage III Pancreatic Cancer|Stage IV Pancreatic Cancer
Interventions: DRUG: erlotinib hydrochloride|DRUG: selumetinib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of Allogeneic Osteoblastic Cells (ALLOB®) Single Implantation in Tibial Fracture
Status: UNKNOWN
Conditions: Tibial Fracture
Interventions: BIOLOGICAL: ALLOB|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Omega-3 Fatty Acids for Perinatal Depression
Status: COMPLETED
Conditions: Depression|Depression, Postpartum
Interventions: DRUG: Omega-3 Fatty Acids (EPA plus DHA)|BEHAVIORAL: Supportive psychotherapy|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Survey on the Expectations of Adolescents With Juvenile Idiopathic Arthritis (JIA) Regarding Knowledge and Communication With Health Care Professionals in the Field of Sexual Health, and Their Parents' Views on the Subject. (SNAPS-JIA)
Status: UNKNOWN
Conditions: Juvenile Idiopathic Arthritis
Interventions: OTHER: questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: GenTeal in Perioperative Treatment of Laser Assisted in Situ Keratomileusis LASIK Patients
Status: COMPLETED
Conditions: Corneal Epithelium Defect
Interventions: DRUG: 0.3% hypromellose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Cognitive-behavioral Intervention of Rumination for Perfectionists
Status: COMPLETED
Conditions: Perfectionism|Rumination - Thoughts|Anxiety|Depression
Interventions: BEHAVIORAL: A cognitive-behavioral approach of rumination as intervention for overgeneral mode of processing in perfectionism
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visual Guidelines and Tutoring in Pediatric Urological Surgery
Status: COMPLETED
Conditions: Hypospadias|Undescended Testis|Hydrocele|Ureteropelvic Junction Stenosis|Anxiety
Interventions: BEHAVIORAL: Picture book|BEHAVIORAL: Standard preoperative education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The 5Ad Diet for Functional Bowel Disorders
Status: RECRUITING
Conditions: Functional Bowel Disorder|Irritable Bowel Syndrome|Food Intolerance|Food Intolerance Syndromes
Interventions: OTHER: The 5Ad Diet|OTHER: The Low FODMAP Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT)
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Naproxen Sodium (Aleve)|DRUG: Celecoxib (Celebrex)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Does the Use of a Videolaryngoscope Modifies Anesthetic Induction ?
Status: COMPLETED
Conditions: Tracheal Intubation
Interventions: PROCEDURE: Tracheal intubation|DRUG: Propofol and remifentanil anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of RG1662 in Adults and Adolescents With Down Syndrome (CLEMATIS)
Status: COMPLETED
Conditions: Down Syndrome
Interventions: DRUG: Placebo|DRUG: RG1662|DRUG: RG1662
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pectopexy Surgery Without Mesh
Status: RECRUITING
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: Comparison of pre and postoperative POP-Q values of the patients|PROCEDURE: Comparison of pre and postoperative PISQ-12 scores of the patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of the Advanced Symptom Management System (ASyMS) in Canadian Cancer Patients
Status: COMPLETED
Conditions: Supportive Care|Cancer
Interventions: DEVICE: ASyMS-Can
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Arrested Versus Beating Heart Techniques in Coronary Revascularisation
Status: UNKNOWN
Conditions: Coronary Artery Bypass Grafting
Interventions: PROCEDURE: Conventional Coronary Artery Bypass|PROCEDURE: Off-Pump Coronary Artery Bypass|PROCEDURE: Pump-Assisted Coronary Artery Bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis Trial
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DRUG: Spironolactone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Social Determinants of Health in Glioblastoma Population
Status: COMPLETED
Conditions: Glioma|Astrocytoma|Oligodendroglioma|Ependymoma|Ganglioglioma|Pleomorphic Xanthoastrocytoma
Interventions: OTHER: Part 1 Survey Group|OTHER: Part 2 Focus Group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Determinants of Muscle Strength in Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DEVICE: Handheld dynamometer|BIOLOGICAL: Creatinine index|DEVICE: Electrical bioimpedance analysis|OTHER: "Voorrips" score questionnaire|BIOLOGICAL: Inflammatory and nutritional status
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial Using Velcade Plus Chemoradiation for Central Nervous System, Head and Neck, and Cervical Cancer Patients
Status: COMPLETED
Conditions: Brain Cancer|Head and Neck Cancer|Cervix Cancer|Central Nervous System Neoplasms
Interventions: DRUG: Velcade (bortezomib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Assessment of Intra-lesional 3% Polidocanol Solution in the Treatment of Digital Myxoid Cyst
Status: TERMINATED
Conditions: Ganglion Cysts
Interventions: DRUG: polidocanol|PROCEDURE: infra-red coagulation|PROCEDURE: cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EXPEDITE: A Study of Remodulin Induction Followed by Orenitram Optimization to Treat Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Intravenous/Subcutaneous Treprostinil; Oral Treprostinil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Donepezil for Treatment of Cocaine Dependence
Status: COMPLETED
Conditions: Cocaine Abuse and Dependence
Interventions: DRUG: Donepezil, 5 mg daily|OTHER: Oral Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multiple-Ascending Dose Study of MS-553 in Healthy Volunteers
Status: COMPLETED
Conditions: Safety and PK in Healthy Volunteers
Interventions: DRUG: MS-553|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Measles and Rubella Vaccine Microneedle Patch Phase 1-2 Age De-escalation Trial
Status: COMPLETED
Conditions: Measles|Rubella|Vaccination|Healthy
Interventions: BIOLOGICAL: Measles Rubella Vaccine (MRV-SC)|BIOLOGICAL: MRV-MNP|OTHER: PLA-MNP|OTHER: PLA-SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of Ketamine Infusion Compared With Traditional Anti-epileptic Agents in Refractory Status Epilepticus
Status: WITHDRAWN
Conditions: Refractory Epilepsy
Interventions: DRUG: Traditional Treatment (Group T)|DRUG: Ketamine Infusion (Group K)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety and Dose Ranging Study of Human Insulin Receptor MAb-IDUA Fusion Protein in Adults and Children With MPS I
Status: COMPLETED
Conditions: Mucopolysaccharidosis I
Interventions: DRUG: AGT-181
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of HLX10, Trastuzumab and Chemotherapy in First-line Treatment of HER2-positive Recurrent/Metastatic Gastric Cancer
Status: NOT_YET_RECRUITING
Conditions: HER2-positive Gastric Cancer
Interventions: DRUG: HLX10, Trastuzumab and Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Randomized Trial Evaluating Four Anti-pneumococcal Vaccine Strategies With Fractionated Doses of Non Conjugate Polysaccharide Vaccine to Prevent Hyporesponse in Healthy Volunteers
Status: COMPLETED
Conditions: Pneumococcal Infection
Interventions: BIOLOGICAL: Pneumo 23® 0,5|BIOLOGICAL: Pneumo 23® 0,1|BIOLOGICAL: Prevenar13® 0,5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Home-Combo: an Online Home-based Combined Exercise Intervention for Women With Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Chemotherapy Effect
Interventions: BEHAVIORAL: Home-based combined exercise program with self-selected intensity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Colorimetric, Ultra-structural and Elemental Comparison of Dental Enamel Defects
Status: RECRUITING
Conditions: Amelogenesis Imperfecta|Dental Fluoroses|Hypomineralization Molar Incisor
Interventions: OTHER: spectrophotometer|OTHER: Biological (protein analysis by western blot or mass spectrometry of matrix proteins), structural (electron microscopy) and physico-chemical analyses
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Post-discharge Cessation for Smoking Patients
Status: RECRUITING
Conditions: Smoking Cessation|Post-discharge|Mobile Health
Interventions: BEHAVIORAL: 5As brief advice|BEHAVIORAL: Self-help e-booklet|BEHAVIORAL: Nurse-led mHealth intervention|BEHAVIORAL: Regular intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Treatment of Vesico-vaginal Fistula by a Robot Assisted Laparoscopy : Results of a Multicentric Series (FFVLARO)
Status: UNKNOWN
Conditions: Vesico-vaginal Fistula
Interventions: PROCEDURE: vesico-vaginal fistula robot assisted laparoscopic repair
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Traditional Chinese Medicine Regimen-based Lifestyle Mobile Health APP in Prediabetes
Status: COMPLETED
Conditions: PreDiabetes
Interventions: OTHER: Traditional Chinese medicine regimen-based lifestyle mobile health APP|OTHER: Lifestyle mobile health APP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Changes in Tumor Burden in 68Ga-PSMA-11 PET/CT and 177Lu-PSMA SPECT/CT in Metastatic Castration-resistant Prostate Cancer
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer Metastatic
Interventions: DRUG: 177Lu-PSMA-617
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dietary Habits, Metabolome, Immune Profile and Microbiota in Patients With Bone Sarcoma
Status: RECRUITING
Conditions: Osteosarcoma|Ewing Sarcoma
Interventions: OTHER: EPIC-COS Food Frequency Questionnaire diet Evaluation|OTHER: Metabolome, Microbiota, Lymphocytes subpopulations
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Intrathoracic Pressure Regulation on Traumatic Brain Injury
Status: TERMINATED
Conditions: Head Injury
Interventions: DEVICE: -7 cm H2O ITPR|DEVICE: -12cm H2O ITPR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sleep-specific DBS Therapy in Parkinson's Disease
Status: RECRUITING
Conditions: Deep Brain Stimulation|Parkinson's Disease and Parkinsonism|Dystonia
Interventions: OTHER: Clinically optimized deep brain stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Post-Market Clinical Follow-Up Study on the Safety and Performance of Ennovate® Cervical
Status: RECRUITING
Conditions: Spine Fracture|Degenerative Disc Disease|Spinal Instability|Spinal Tumor|Degenerative Myelopathy
Interventions: DEVICE: posterior stabilization for the cervical spine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Efficacy & Safety Study of Esomeprazole Versus Placebo for the Prevention of Gastric and Duodenal Ulcers With NSAID
Status: COMPLETED
Conditions: Gastric Ulcer|Duodenal Ulcer|Rheumatoid Arthritis|Osteoarthritis|Lumbago
Interventions: DRUG: Esomeprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: External Focus of Attention Feedback to Reduce Risk of Non-contact ACL Injury
Status: RECRUITING
Conditions: Anterior Cruciate Ligament Injuries
Interventions: OTHER: Internal focus of attention feedback|OTHER: Visual internal focus of attention feedback|OTHER: Auditory external focus of attention feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Safety of and Immune Response to HIV-MAG DNA Vaccine With or Without Plasmid IL-12 Adjuvant Delivered Intramuscularly Via Electroporation Followed by VSV-gag HIV Vaccine Boost in Healthy, HIV-Uninfected Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: HIV-MAG vaccine|BIOLOGICAL: IL-12 pDNA adjuvant|BIOLOGICAL: VSV HIV gag vaccine|BIOLOGICAL: Placebo|DEVICE: Ichor Medical Systems TriGrid™ Delivery System (TDS) electroporation (EP) device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Left Bundle Branch Area Pacing in Patients With Heart Failure
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction|Left Bundle Branch Area Pacing|Heart Failure|Cardiac Resynchronization Therapy|Cardiac Resynchronization Therapy Devices|Conduction System Pacing|Left Bundle-Branch Block
Interventions: DEVICE: left bundle branch area pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parasternal Access for ShockS and Pacing With an acUtely Placed Less-invasive Lead for EV-ICD (PASS PULL EV-ICD) Study
Status: COMPLETED
Conditions: Ventricular Arrhythmia|Ventricular Tachycardia|Ventricular Fibrillation
Interventions: DEVICE: AtaCor EV-ICD Lead
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Radicle Energy 24: A Study of Health and Wellness Products on Fatigue and Related Health Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Fatigue|Energy
Interventions: DIETARY_SUPPLEMENT: Energy Placebo Control Form 1|DIETARY_SUPPLEMENT: Energy Active Study Product 1.1 Usage|DIETARY_SUPPLEMENT: Energy Active Study Product 1.2 Usage|DIETARY_SUPPLEMENT: Energy Placebo Control Form 2|DIETARY_SUPPLEMENT: Energy Active Study Product 2.1 Usage|DIETARY_SUPPLEMENT: Energy Placebo Control Form 3|DIETARY_SUPPLEMENT: Energy Active Study Product 3.1 Usage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Emtricitabine Plus Adefovir Dipivoxil for Naive Chinese HBV Related Cirrhosis Patients
Status: UNKNOWN
Conditions: Hepatitis B, Chronic|Fibrosis
Interventions: DRUG: Emtricitabine plus adefovir dipivoxil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hematopoietic Stem Cell Therapy for Patients With Refractory Myasthenia Gravis
Status: TERMINATED
Conditions: Myasthenia Gravis
Interventions: BIOLOGICAL: Hematopoietic Stem Cell Transplantation|DRUG: Cyclophosphamide|DRUG: ATG (rabbit)|DRUG: Mesna|DRUG: Methylprednisolone|DRUG: G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Arthroscopic Tennis Elbow Release With Arthroscopic Debridement
Status: RECRUITING
Conditions: Tennis Elbow
Interventions: PROCEDURE: Non operative|PROCEDURE: Arthroscopic tennis elbow release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Megadose Vitamin C in Sepsis
Status: RECRUITING
Conditions: Sepsis|Septic Shock
Interventions: DRUG: Vitamin C|DRUG: 5% glucose injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of Biophysical Parameters as Long-term Predictors of Pulmonary Vein Isolation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: pulmonary vein (PV) isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Advanced Lower Extremity Neuroprostheses
Status: RECRUITING
Conditions: Spinal Cord Injuries|Stroke|Paralysis|Tetraplegia|Paraplegia
Interventions: DEVICE: IST-16 (16-channel implanted stimulator-telemeter)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Anticoagulation in Critically Ill Patients With COVID-19 (The IMPACT Trial)
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Enoxaparin sodium|DRUG: Unfractionated heparin|DRUG: Fondapariniux|DRUG: Argatroban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coronary Microcirculation Assessment After Primary Angioplasty in Myocardial Infarction
Status: TERMINATED
Conditions: STEMI - ST Elevation Myocardial Infarction
Interventions: DIAGNOSTIC_TEST: Absolute coronary flow and resistance measurements|DIAGNOSTIC_TEST: IMR measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: HIV-1 Vaccine Booster in Previously Immunized Uninfected Adult Volunteers
Status: COMPLETED
Conditions: Healthy|HIV Infections
Interventions: BIOLOGICAL: VRC-HIVADV014-00-VP booster|DRUG: VRC-HIVADV014-00-VP
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Refractory Ascites in Patients With Liver Cirrhosis, and the Potential Treatment With 48 Hours Infusion of Ularitide.
Status: TERMINATED
Conditions: Cirrhosis, Liver|Ascites Hepatic
Interventions: DRUG: Ularitide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of N-acetylcysteine Versus Calcium Hydroxide Used as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Levels of MMP -9 in Periapical Fluids in Patients With Necrotic Pulp
Status: NOT_YET_RECRUITING
Conditions: Intracanal Medication|N-acetylcystine|Calcium Hydroxide|Mediators
Interventions: DRUG: N-acetyl cysteine|DRUG: Calcium hydroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Probiotic Supplementation on the Results of Gastric Bypass Surgery
Status: UNKNOWN
Conditions: Gastric Bypass Surgery
Interventions: DIETARY_SUPPLEMENT: probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diabetic Foot Ulcer (DFU) Biofilm Infection and Recurrence
Status: RECRUITING
Conditions: Chronic Wounds|Biofilm Infection|Trans-epidermal Water Loss (TEWL)|Diabetic Foot|Diabetic Foot Infection
Interventions: PROCEDURE: Observation of wound infection and time to wound closure|DEVICE: Pericam PSI-NR Laser Speckle imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Fissure Sealants Bonded With Different Universal Adhesives
Status: NOT_YET_RECRUITING
Conditions: Dental Caries on Pit and Fissure Surface
Interventions: DEVICE: Adhesive agent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Prospective Randomized Controlled Trial to Evaluate the Effectiveness of the Two Different Appliances in the Treatment of Class II Division 1 Malocclusion
Status: TERMINATED
Conditions: Class II Division 1 Malocclusion
Interventions: OTHER: Dynamax appliance|OTHER: Twin-block appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-pharmacological Interventions for Procedural Pain in Premature Neonates
Status: COMPLETED
Conditions: Prevention of Procedural Pain|Reduction of Procedural Pain|Biochemical Effects of Oral Dextrose
Interventions: OTHER: Oral glucose, facilitated tucking, NNS|OTHER: Oral glucose and NNS|OTHER: Facilitated tucking and NNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Chart Review to Evaluate the Safety and Efficacy of Phrenic Nerve Reconstruction for the Treatment of Diaphragmatic Paralysis
Status: ACTIVE_NOT_RECRUITING
Conditions: Diaphragm Issues|Diaphragm; Paralysis, Due to Accidental Section of Phrenic Nerve During Procedure|Breath Shortness|Diaphragmatic Paralysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Carotid Artery Stenting During Endovascular Treatment of Acute Stroke
Status: RECRUITING
Conditions: Stroke, Acute|Stroke, Ischemic|Carotid Stenosis|Carotid Atherosclerosis|Carotid Occlusion
Interventions: PROCEDURE: carotid artery stenting during EVT|OTHER: no carotid artery stenting during EVT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of Anti-Mucin1 (MUC1) CAR T Cells for Patients With MUC1+ Advanced Refractory Solid Tumor
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma|Non-small Cell Lung Cancer|Pancreatic Carcinoma|Triple-Negative Invasive Breast Carcinoma
Interventions: BIOLOGICAL: anti-MUC1 CAR T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apixaban for Intrahepatic Non Cirrhotic Portal Hypertension
Status: ACTIVE_NOT_RECRUITING
Conditions: Intrahepatic Non Cirrhotic Portal Hypertension
Interventions: DRUG: Apixaban|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Comparative Bioavailability of Two Injectable Suspension Formulations of Medroxyprogesterone Acetate+Estradiol Cypionate
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Test formulation|DRUG: Reference formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Bioequivalence of an Oral Suspension Formulation, an Oral Solution Formulation, and the Marketed Tablet Formulation of Levofloxacin in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Levofloxacin oral suspension; Levofloxacin oral solution; and Levofloxacin marketed tablet formulations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prone Position During ECMO in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Hypoxaemic Patient
Status: COMPLETED
Conditions: SARS CoV 2 Infection|Hypoxemic Respiratory Failure
Interventions: OTHER: Prone position on ECMO patient
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Resource-oriented Music Therapy for Psychiatric Patients With Low Therapy Motivation
Status: COMPLETED
Conditions: Mental Disorders|Mood Disorders|Personality Disorders|Schizophrenia and Disorders With Psychotic Features
Interventions: PROCEDURE: Resource-oriented music therapy|PROCEDURE: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Absolute Bioavailability of Intranasal and Oral Esketamine and the Effects of Clarithromycin on the Pharmacokinetics of Intranasal Esketamine in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Esketamine|DRUG: Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tailored Web-Based Intervention for Cancer Patients and Family Caregivers
Status: COMPLETED
Conditions: Breast Cancer|Colorectal Cancer|Lung Cancer|Prostate Cancer
Interventions: BEHAVIORAL: FOCUS-Web
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mesenchymal Stromal Cells in Adults With Recessive Dystrophic Epidermolysis Bullosa
Status: UNKNOWN
Conditions: Recessive Dystrophic Epidermolysis Bullosa
Interventions: DRUG: Mesenchymal stromal cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of the Efficacy, Safety, and Pharmacokinetics of A 36-Week Refill Regimen for the Port Delivery System With Ranibizumab in Patients With Neovascular Age-Related Macular Degeneration (Velodrome)
Status: RECRUITING
Conditions: Neovascular Age-related Macular Degeneration (nAMD)
Interventions: DRUG: Ranibizumab|DEVICE: Port Delivery System with Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of PD-1 ± mFOLFOX6 Neoadjuvant Therapy in Local Advanced sMPCC
Status: RECRUITING
Conditions: Multiple Cancer|Colorectal Cancer
Interventions: DRUG: MSI-H/MSS (dMMR/pMMR) mixed sMPCC: combination of mFOLFOX6+PD-1 monoclonal antibody neoadjuvant therapy|DRUG: All-MSI-H (dMMR) sMPCC: single-drug PD-1 monoclonal antibody neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S-1 and Bevacizumab in Treating Patients With Colorectal Cancer That is Recurrent or Cannot Be Removed by Surgery
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: tegafur-gimeracil-oteracil potassium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of AGN-190584 Eye Drops to Assess Safety and Efficacy in Participants Aged 40-80 Years With Pseudophakic Presbyopia
Status: WITHDRAWN
Conditions: Presbyopia
Interventions: DRUG: AGN-190584|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Ambulatory Respiratory Assist Device in Chronic Obstructive Pulmonary Disease Patients
Status: UNKNOWN
Conditions: COPD|Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: AIR-AD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Anaesthetic and Steroid in the Ureter
Status: UNKNOWN
Conditions: Pain, Postoperative|Ureter Stone
Interventions: DRUG: Levobupivacaine|DRUG: Dexamethasone Sodium Phosphate|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Niacin Plus Statin to Prevent Vascular Events
Status: TERMINATED
Conditions: Cardiovascular Diseases|Heart Diseases|Cerebrovascular Accident|Coronary Disease|Atherosclerosis|Myocardial Infarction
Interventions: DRUG: Extended release niacin|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of (1,3), (1,6)-Beta-D-glucan on Insulin Sensitivity and Inflammatory Markers of the Metabolic Syndrome
Status: COMPLETED
Conditions: Overweight
Interventions: DIETARY_SUPPLEMENT: Beta-D-Glucan|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Electro-fetal monıtorısıon Sound on Anxiety, paın and Postpartum Bonding at the First Phase of Delivery
Status: RECRUITING
Conditions: Delivery Fear|Labor Pain|Maternal-Fetal Relations
Interventions: DEVICE: Non-stress test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Galcanezumab (LY2951742) in Healthy Chinese Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Galcanezumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PET Dynamics to Response-Adapted Neoadjuvant Therapy in TNBC
Status: RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Pembrolizumab|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Olaparib|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Safety and Efficacy of Aliskiren Alone and in Combination With Ramipril in Hypertensive, Diabetic Patients.
Status: COMPLETED
Conditions: Hypertension, Diabetes Mellitus
Interventions: DRUG: aliskiren
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Emactuzumab for Tenosynovial Giant Cell Tumor (TGCT)
Status: RECRUITING
Conditions: TGCT
Interventions: DRUG: Emactuzumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Time Intervals for Rescue Treatment on Eradication Effect of Helicobacter Pylori Infection
Status: NOT_YET_RECRUITING
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Amoxicillin + Tetracycline + Bismuth + Esomeprazole|DRUG: Amoxicillin + Tetracycline + Bismuth + Vonoprazan|DRUG: Amoxicillin + Tetracycline + Bismuth + Tegoprazan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rivaroxaban vErsus Warfarin for Antithrombotic TheRapy in Patients With LeFt Ventricular Thrombus After Acute STEMI
Status: COMPLETED
Conditions: Left Ventricular Thrombus|ST Segment Elevation Myocardial Infarction
Interventions: DRUG: Rivaroxaban 15 MG|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Digital CBTI for Comorbid Insomnia in Chronic Migraine
Status: RECRUITING
Conditions: Insomnia Chronic|Migraine Disorders
Interventions: BEHAVIORAL: Digital CBT-I|BEHAVIORAL: Sleep Hygiene Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carboplatin Plus Etoposide With or Without MPDL3280A in Untreated Extensive Stage Small Cell Lung Cancer
Status: TERMINATED
Conditions: Small Cell Lung Cancer ( SCLC )
Interventions: DRUG: Carboplatin|DRUG: Etoposide|BIOLOGICAL: MPDL3280A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Insulin vs Rapid-acting Injections for Post-meal Glucose Control in Women With Gestational Diabetes
Status: NOT_YET_RECRUITING
Conditions: Diabetes, Gestational|Pregnancy Complications|Glucose Metabolism Disorders|Glucose Intolerance During Pregnancy
Interventions: DRUG: Inhaled Technosphere Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tachikawa Project for Prevention of Posttraumatic Stress Disorder With Polyunsaturated Fatty Acid (TPOP): TPOP-01 Study
Status: COMPLETED
Conditions: Trauma|Posttraumatic Stress Disorder
Interventions: DIETARY_SUPPLEMENT: Omega-3 Polyunsaturated Fatty Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION