pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Carbetocin at Elective Cesarean Delivery
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Carbetocin|DRUG: Carbetocin|DRUG: Carbetocin|DRUG: Carbetocin|DRUG: Carbetocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FX06 to Rescue Acute Respiratory Distress Syndrome During Covid-19 Pneumonia
Status: COMPLETED
Conditions: Ards|Covid19|Pneumonia
Interventions: DRUG: FX06|DRUG: Placebo of FX06
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vascular Effects Through Sirolimus vs. Paclitaxel DCB Implantation
Status: RECRUITING
Conditions: Peripheral Arterial Disease|Flow-mediated Dilation|Drug Eluting Balloon|Infrainguinal Peripheral Arterial Disease
Interventions: DEVICE: SELUTION SLR DCB|DEVICE: Paclitaxel DCB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study for the Evaluation of the Safety and Initial Performance of the ClearRing System for the Treatment of Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Benign ProstaticHyperplasia (BPH)
Interventions: DEVICE: ClearRing™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Investigate the Pharmacokinetic Drug-drug Interaction of Clevudine and Adefovir Dipivoxil After Oral Administration in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Clevudine, Adefovir dipivoxil , Clevudine+Adefovir dipivoxil|DRUG: Clevudine; Adefovir dipivoxil ,Clevudine +Adefovir dipivoxil|DRUG: Clevudine,Adefovir dipivoxil ,Clevudine +Adefovir dipivoxil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Zinc on Iron Bioavailability From Fortified Extruded Rice Fortified With Ferric Pyrophosphate
Status: COMPLETED
Conditions: Iron Deficiency
Interventions: OTHER: Ferric Pyrophosphate and Zinc Oxide|OTHER: Ferrous sulfate|OTHER: Ferric Pyrophosphate and Zinc Sulfate|OTHER: Ferric Pyrophosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Investigate the Safety, Tolerability and Pharmacokinetics of ABY-035
Status: COMPLETED
Conditions: Psoriasis|Healthy Subjects
Interventions: DRUG: Placebo|DRUG: ABY-035 i.v.|DRUG: ABY-035 s.c.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Elastic Compression Stockings and Varicose Veins Recurrence
Status: RECRUITING
Conditions: Varicose Veins|Chronic Venous Insufficiency
Interventions: DEVICE: Graduated Compression Stocking: continuous using|DEVICE: Graduated Compression Stocking: intermittent using
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Denosumab in Incomplete Patients Spinal Cord Injury
Status: TERMINATED
Conditions: Secondary Osteoporosis|Spinal Cord Injury
Interventions: DRUG: Denosumab (Prolia)|OTHER: Placebo (normal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Hypoglycemia Among Diabetes Patients Admitted to Internal Medicine Departments With Nutritional Care
Status: UNKNOWN
Conditions: Hypoglycemia|Malnutrition; Diabetes
Interventions: DIETARY_SUPPLEMENT: Glucerna
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparing Total Hip Arthroplasty and Hemi-Arthroplasty on Secondary Procedures and Quality of Life in Adults With Displaced Hip Fractures
Status: COMPLETED
Conditions: Hip Fractures|Femoral Neck Fractures
Interventions: DEVICE: Total hip arthroplasty|DEVICE: Hemi-arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Asfotase Alfa in Severely Affected Infants With Hypophosphatasia (HPP)
Status: COMPLETED
Conditions: Hypophosphatasia (HPP)
Interventions: BIOLOGICAL: asfotase alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microtransplantation for Advanced and Relapsed Solid Tumors
Status: RECRUITING
Conditions: Solid Tumors
Interventions: BIOLOGICAL: microtransplantation, HLA-mismatched donor peripheral stem cell infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of 50561 in Patients With Mild or Moderate Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer's Disease
Interventions: DRUG: 50561 high dose|DRUG: 50561 low dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"
Status: RECRUITING
Conditions: Heart Failure|Cardiovascular Diseases
Interventions: DIAGNOSTIC_TEST: NT-proBNP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: autologous bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of a Patient Preferences Shared Decision-Making Encounter Tool in Clinical Practice for Patients With DLBCL and FL
Status: COMPLETED
Conditions: Diffuse Large B Cell Lymphoma|Follicular Lymphoma
Interventions: BEHAVIORAL: Carevive CarePlanning System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Autologous CAR T-Cells Targeting the GD2 Antigen for Lung Cancer
Status: RECRUITING
Conditions: Lung Cancer|Small Cell Lung Carcinoma|Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: iC9.GD2.CAR.IL-15 T Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Creating Opportunities Through Mentoring, Parenting and Safe Spaces - Democratic Republic of Congo
Status: COMPLETED
Conditions: Sexual Assault|Interpersonal Relations|Marital Status|Domestic Violence
Interventions: BEHAVIORAL: COMPASS|BEHAVIORAL: COMPASS plus parenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of K-rod Dynamic Stabilization System in the Repair of Lumbar Degenerative Diseases
Status: UNKNOWN
Conditions: Intervertebral Disk Degeneration
Interventions: DEVICE: K-rod dynamic stabilization system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topotecan and Carboplatin in the First-Line Treatment of Patients With Extensive Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Small Cell
Interventions: DRUG: Topotecan|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Umbilical Cord Mesenchymal Stem Cells Injection for Ocular Corneal Burn
Status: UNKNOWN
Conditions: Ocular Corneal Burn
Interventions: BIOLOGICAL: human umbilical cord mesenchymal stem cells|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Drug Interaction Study to Evaluate the Pharmacokinetics of ASP015K and Metformin
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: peficitinib|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: DetectAB - Detecting Antibiotics
Status: COMPLETED
Conditions: Antibiotic Drug Concentration in Sweat
Interventions: DIAGNOSTIC_TEST: analysis of last resort antibiotic drug (Flucloxacillin, Imipenem, Vancomycin or Cefepim) in sweat and blood
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy Study of AI LVEF
Status: COMPLETED
Conditions: Heart Failure, Systolic|Heart Failure, Diastolic
Interventions: OTHER: Automated annotation of the left ventricle through deep learning|OTHER: Sonographer Measurement of LVEF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial Comparing SOC +Skin IQ MCM vs SOC for Pressure Ulcer (PU)
Status: UNKNOWN
Conditions: Pressure Ulcer
Interventions: DEVICE: Skin IQ™ MCM Coverlet|OTHER: Pressure redistribution surface
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Rapalogues for Autism Phenotype in TSC: A Feasibility Study
Status: COMPLETED
Conditions: Tuberous Sclerosis Complex|Self-injury|Autism
Interventions: DRUG: Sirolimus|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Imaging Study Evaluating Dalotuzumab (MK0646) in Combination With Erlotinib for Patients With Non-Small Cell Lung Cancer (MK-0646-008)
Status: COMPLETED
Conditions: Carcinoma, Non-small Cell Lung
Interventions: DRUG: Comparator: erlotinib + dalotuzumab|DRUG: Comparator: erlotinib monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Case Management and Peer Support Groups for Prophylaxis Adherence in Rheumatic Heart Disease
Status: COMPLETED
Conditions: Rheumatic Heart Disease
Interventions: BEHAVIORAL: Case Manager and Peer Support Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diet Oil Induced Stimulation of GLP-1
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Diet oil|DIETARY_SUPPLEMENT: Olive oil|DIETARY_SUPPLEMENT: Carrot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Beta-lactam Intermittent Versus Continuous Infusion and Combination Antibiotic Therapy in Sepsis
Status: RECRUITING
Conditions: Sepsis
Interventions: DRUG: continuous pivotal βL-AB|DRUG: intermittent pivotal βL-AB|DRUG: AG infusion most 1 dose|DRUG: AG infusion for 5 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Do We Need High-Flexing Total Knee Arthroplasty to Improve the Survivorship and to Decrease the Incidence of Osteolysis?
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: legacy posterior stabilized high-flexion (NexGen LPS-Flex)|DEVICE: legacy posterior stabilized standard (NexGen LPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Trial of Oral Penicillin Versus Cefuroxim for Treatment of Perianal Streptococcal Dermatitis
Status: TERMINATED
Conditions: Streptococcal Infections
Interventions: DRUG: Penicillin versus cefuroxim per os
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: M1 Schizophrenia PET Study
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Healthy
Interventions: DRUG: 11C-EMO - A Novel PET Radiotracer for Muscarinic M1 Receptor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of TAK-994 in Adults With Narcolepsy
Status: TERMINATED
Conditions: Narcolepsy Type 1 (NT 1)
Interventions: DRUG: TAK-994|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irinotecan Liposome Combined With Anlotinib as Second-line Regimen for SCLC
Status: NOT_YET_RECRUITING
Conditions: Small Cell Lung Cancer Recurrent
Interventions: DRUG: Irinotecan Liposome|DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients
Status: RECRUITING
Conditions: Respiratory Failure
Interventions: DIAGNOSTIC_TEST: Cuff Leak Test|DRUG: Dexamethasone 4mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Paliperidone Palmitate 6-Month Formulation
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: PP6M|DRUG: PP3M 350 mg eq.|DRUG: PP3M 525 mg eq.|DRUG: PP1M|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Legend: TRELEGY Real World Chronic Obstructive Pulmonary Disease (COPD) Effectiveness Study
Status: WITHDRAWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Inhaled corticosteroids/long-acting beta2-adrenergic/long-acting muscarinic receptor antagonists|DRUG: Fluticasone furoate/umeclidinium/vilanterol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Cortisol on Alcohol Craving in Alcohol Dependence
Status: COMPLETED
Conditions: Alcohol Craving|Psychological Stress|Physiological Stress
Interventions: DRUG: Cortisol 20mg|DRUG: Placebo Mannitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Telerehabilitation in Coronary Heart Disease
Status: COMPLETED
Conditions: Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))|Myocardial Infarction|Percutaneous Transluminal Cutting Balloon Angioplasty of Popliteal Vein Using Fluoroscopic Guidance
Interventions: BEHAVIORAL: Center-based cardiac rehabilitation|BEHAVIORAL: Home-based training with telemonitoring guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Trial of taVNS for SRNS in Children (kidNEY-VNS)
Status: RECRUITING
Conditions: Nephrotic Syndrome in Children|Minimal Change Disease|Focal Segmental Glomerulosclerosis
Interventions: DEVICE: trascutaneous auricular vagus nerve stimulation|DEVICE: Sham device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colchicine and Inflammation in Aortic Stenosis
Status: RECRUITING
Conditions: Aortic Valve Disease|Aortic Valve Stenosis|Aortic Valve Calcification|Inflammation|Calcification|Cardiovascular Diseases
Interventions: DRUG: Colchicine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Self-Adaptive Immersive Virtual Reality Serious Game to Enhance Motor Skill Learning and Attention in Older Adults
Status: RECRUITING
Conditions: Older Adults|Aging Well|Aging
Interventions: DEVICE: Self-adaptive serious game|DEVICE: Non-adaptive serious game
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Implementation of Evidence-based Treatments for On-campus Eating Disorders
Status: COMPLETED
Conditions: Eating Disorders (Excluding Anorexia Nervosa)|Depression
Interventions: BEHAVIORAL: High Intensity Strategy: Train-the-trainer|BEHAVIORAL: Low Intensity Strategy: Expert Consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Optimized-dose Amoxicillin Versus Standard-dose Amoxicillin for Quadruple Therapy in Helicobacter Pylori Eradication
Status: COMPLETED
Conditions: Helicobacter Pylori
Interventions: DRUG: optimized quadruple therapy|DRUG: standard quadruple therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of TL-925 for the Treatment of Allergic Conjunctivitis
Status: RECRUITING
Conditions: Allergic Conjunctivitis
Interventions: DRUG: TL-925|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risk of CYP2C19 Phenoconversion in Healthy Volunteers With Rapid, Normal, and Intermediate Predicted Metabolizers' Status
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: Voriconazole 200mg|DRUG: FluvoxaMINE 50 Mg Oral Tablet|DRUG: Omeprazole 10 MG Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: PROCEDURE: MT+CAS with IV-AP|PROCEDURE: MT+CAS with PO-AP|PROCEDURE: MT+CAT with PO-AP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of LT3001 on Treating the Acute Ischemic Stroke
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DRUG: LT3001 Drug:high dose|DRUG: Placebo|DRUG: LT3001 Drug:low dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hydrotherapy Versus Classical Rehabilitation After Surgical Rotator Cuff Repair
Status: COMPLETED
Conditions: Rotator Cuff Tears
Interventions: OTHER: Hydrotherapy|OTHER: Land-based Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Tumor Mutation Burden and Predicted Neo-antigen Burden in Patients With Advanced Melanoma or Bladder Cancer Treated With Nivolumab or Nivolumab Plus Ipilimumab (CA209-260)
Status: COMPLETED
Conditions: Bladder Cancer|Melanoma
Interventions: DRUG: Nivolumab|DRUG: Nivolumab plus Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 4D-flow MRI to Assess Left Ventricular Obstruction in Hypertrophic Cardiomyopathy
Status: COMPLETED
Conditions: Hypertrophic Cardiomyopathy|Obstruction|Echocardiography
Interventions: OTHER: cardiac magnetic resonance imaging (MRI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Single Ascending Dose Study of 9MW3011 in Chinese Healthy Subject
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DRUG: 9MW3011|DRUG: 9MW3011 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Solifenacin Succinate in Patients With Bladder Symptoms Due to Spinal Cord Injury or Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Neurogenic Bladder|Spinal Cord Diseases
Interventions: DRUG: Solifenacin Succinate|DRUG: Solifenacin Succinate|DRUG: Oxybutynin Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reliability and Validity of a Digital Version of a Structured Interview for Children and Adolescents (Kinder-eDIPS)
Status: RECRUITING
Conditions: Psychological Disease
Interventions: DIAGNOSTIC_TEST: Diagnostisches Interview bei psychischen Störungen im Kindes- und Jugendalter, digitale Version (Kinder-eDIPS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Tolerability , Pharmacokinetics and Pharmacodynamics Study of HEC96719 Tablets in Healthy Adult Subjects
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis (NASH)
Interventions: DRUG: HEC96719 tablets|DRUG: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Once-daily Budesonide/Formoterol Turbuhaler 4.5/160 µg in Step Down Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Budesonide/formoterol (160/4.5 μg/d)|DRUG: Budesonide (400μg/d)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Exploring the Safety and Tolerability of INCB081776 in Participants With Advanced Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: INCB081776|DRUG: INCMGA00012
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries Developmental Follow Up
Status: RECRUITING
Conditions: Hypoxic-Ischemic Encephalopathy|Birth Asphyxia
Interventions: OTHER: Umbilical Cord Milking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Isradipine in Early Parkinson Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Isradipine|DRUG: Placebo (for Isradipine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Scar Resection and Reconstruction With Integra and Split Skin Grafts in Patients With Non-Suicidal Self-Inflicted Scars
Status: RECRUITING
Conditions: Nonsuicidal Self Injury|Stigmatization|Cicatrix|Skin Transplantations
Interventions: PROCEDURE: Scar Transformation Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FREEDOM-C: Oral Treprostinil in Combination With an Endothelin Receptor Antagonist (ERA) and/or a Phosphodiesterase-5 (PDE-5) Inhibitor for the Treatment of Pulmonary Arterial Hypertension (PAH)
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Oral treprostinil (UT-15C) sustained release tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Graft-versus-Host Disease Treatment (BMT CTN 0802)
Status: COMPLETED
Conditions: Graft-versus-Host Disease|Immune System Disorders
Interventions: DRUG: Mycophenolate Mofetil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Standard-dose Apixaban AFtEr Very Low-dose ThromboLYSis for Acute Intermediate-high Risk Acute Pulmonary Embolism
Status: TERMINATED
Conditions: Pulmonary Embolism With Acute Cor Pulmonale|Pulmonary Embolism|Pulmonary Embolism With Pulmonary Infarction|Pulmonary Embolism Subacute Massive|Right Ventricular Dysfunction|Right Ventricular Failure
Interventions: DRUG: Alteplase|DRUG: Unfractionated heparin|DRUG: Placebo|DRUG: Apixaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Cingulate and Thalamic DBS for Chronic Refractory Chronic Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Refractory Neuropathic Pain
Interventions: PROCEDURE: Deep brain Stimulation of cingulum anterior
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Memantine as a Supplement to Naltrexone in Treating Heroin Dependence
Status: COMPLETED
Conditions: Opioid Dependence|Heroin Dependence
Interventions: DRUG: Vivitrol|DRUG: memantine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of an Inspiratory Muscle Fatigue Protocol on Older Adults on Respiratory Muscle Strength and Heart Rate Variability
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: OTHER: Inspiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Atrophogenic Effect of Hydrocortison 1% Cream and Pimecrolimus 1% Cream Assessed by Optical Coherence Tomography (OCT) and 20-MHz Ultrasound of Uninvolved Skin in Patients With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: pimecrolimus 1% cream|DRUG: hydrocortison 1% cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Equivalence of Two Generic Butenafine Hydrochloride 1% Creams as Compared to Lotrimin Ultra Cream in Patients With Interdigital Tinea Pedis
Status: TERMINATED
Conditions: Interdigital Tinea Pedis
Interventions: DRUG: Butenafine Hydrochloride 1%|DRUG: Butenafine Hydrochloride 1% B|DRUG: Butenafine Hydrochloride 1%|DRUG: Vehicle A|DRUG: Vehicle B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stent Implantation Versus Medical Therapy for Idiopathic IntracraniaL Hypertension (SIMPLE)
Status: RECRUITING
Conditions: Idiopathic Intracranial Hypotension|Venous Sinus Stenosis
Interventions: PROCEDURE: Stent Implantation|DRUG: Acetazolamide-based medical therapy|BEHAVIORAL: Weight loss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OPTIMAL>60 / DR. CHOP, Improvement of Therapy of Elderly Patients With CD20+ DLBCL Using Rituximab Optimized and Liposomal Vincristine
Status: COMPLETED
Conditions: CD20+ Aggressive B-Cell Lymphoma
Interventions: DRUG: Conventional Vincristine|DRUG: Liposomal Vincristine|DRUG: Ricover-scheme rituximab|DRUG: optimised rituximab-schedule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Nerve Growth Factor or Edaravone on Alcohol-induced Brain Injury
Status: UNKNOWN
Conditions: Alcohol-induced Brain Injury
Interventions: DRUG: Nerve Growth Factor|DRUG: Edaravone|DRUG: Combination of vitamin B1, B6, C, E and mecobalamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Scalp Cooling in Gynecologic Cancer Patients
Status: COMPLETED
Conditions: Gynecologic Cancer|Chemotherapy-Induced Change
Interventions: DEVICE: Scalp cooling Paxman Orbis II system|OTHER: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Two Liver Dialysis Systems : MARS Versus SPAD in Severe Liver Failure
Status: COMPLETED
Conditions: Liver Failure, Acute|Chronic Hepatic Failure
Interventions: DEVICE: MARS albumin dialysis system|DEVICE: SPAD albumin dialysis system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab, Pyrotinib Combined With Dalpiciclib and Endocrine Therapy for HR +/HER2 + Advanced Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Neoplasm Female
Interventions: DRUG: Trastuzumab, Pyrotinib Combined With Dalpiciclib and Endocrine Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of KW-0761 (Mogamulizumab) in Subjects With Previously Treated Peripheral T-cell Lymphoma (PTCL)
Status: COMPLETED
Conditions: Peripheral T-Cell Lymphoma
Interventions: BIOLOGICAL: KW-0761 (mogamulizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Ultrasound-guided vs Bronchoscopy-guided vs Ultrasound-bronchoscopy-guided Percutaneous Tracheostomy Trial
Status: RECRUITING
Conditions: Tracheostomy Complication|Tracheostomy Infection|Tracheostomy Hemorrhage
Interventions: PROCEDURE: Percutaneous dilatational tracheostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Dapagliflozin When Added to Ongoing Metformin and Evogliptin Combination Therapy in Patients With Type 2 Diabetes Who Have Inadequate Glycemic Control
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Dapagliflozin 10mg|DRUG: Placebo|DRUG: Evogliptin 5mg|DRUG: Metformin≥1000mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PK,PD and DDI of Epaminurad and Naproxen in Healthy Volunteers
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DRUG: Epaminurad, Naproxen|DRUG: Epaminurad|DRUG: Epaminurad placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Catgut Embedding in Acupoints on Treating Persistent Atrial Fibrillation After Catheter Ablation
Status: UNKNOWN
Conditions: Persistent Atrial Fibrillation
Interventions: PROCEDURE: Amiodarone hydrochloride tablet + acupoint catgut embedding|DRUG: Amiodarone hydrochloride tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Augment Rotator Cuff for Surgical Treatment of Full Thickness Rotator Cuff Tears
Status: COMPLETED
Conditions: Full Thickness Rotator Cuff Tear
Interventions: DEVICE: Augment Rotator Cuff|PROCEDURE: Standard Suture Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SER-262 Versus Placebo in Adults With Primary Clostridium Difficile Infection to Prevent Recurrence
Status: COMPLETED
Conditions: Clostridium Difficile Infection
Interventions: DRUG: SER-262|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Trastuzumab deruxtecan|DRUG: Durvalumab|DRUG: Paclitaxel|DRUG: Pertuzumab|DRUG: Tucatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaginal DHEA for Women After Breast Cancer
Status: WITHDRAWN
Conditions: Vaginal Dryness|Breast Cancer|Urinary Incontinence|Quality of Life|Sexual Satisfaction
Interventions: DRUG: Vaginal DHEA|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Arthroscopic Subacromial Decompression in Patients Who Are Non-responders to Non-operative Treatment.
Status: RECRUITING
Conditions: Subacromial Impingement Syndrome
Interventions: PROCEDURE: Glenohumeral arthroscopy + Arthroscopic Subacromial Decompression|PROCEDURE: Glenohumeral arthroscopy + lateral skin incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Degarelix in Controlled Ovarian Hyperstimulation (COH) Protocol for Women With PoliCystic Ovarian Syndrome (PCOS)
Status: COMPLETED
Conditions: PCOS|OHSS|INFERTILITY
Interventions: DRUG: degarelix (long acting GnRH antagonist)|DRUG: cetrorelix 0.25mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability, and the Efficacy of Si-544 in Adults With Psoriasis Vulgaris or Psoriatic Arthritis
Status: RECRUITING
Conditions: Psoriasis Vulgaris|Psoriatic Arthritis
Interventions: DRUG: si-544|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ECC5004 DDI Study With Atorvastatin, Rosuvastatin, Digoxin and Midazolam in Healthy Participants
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: ECC5004|DRUG: Midazolam|DRUG: Rosuvastatin|DRUG: Digoxin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Pharmacokinetics (PK) and Safety of Tavapadon in Participants With Severe Renal Impairment Compared to Participants With Normal Renal Function
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Tavapadon
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Attenuation by Aes-103 of Hypoxia Mediated Decrements in Endurance Exercise Performance
Status: COMPLETED
Conditions: Hypoxia
Interventions: DRUG: Placebo|DRUG: Aes-103|DRUG: Aes-103
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of a Crowd-Powered Web Platform for Depression and Anxiety
Status: COMPLETED
Conditions: Depression, Anxiety
Interventions: BEHAVIORAL: ADAPT Platform (Treatment)|BEHAVIORAL: ADAPT Comparison (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immune Profile in Subjects With New Onset Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: PROCEDURE: Inguinal lymph node fine needle aspirate biopsy|PROCEDURE: Inguinal lymph node core biopsy|PROCEDURE: Peripheral blood collection|OTHER: Pre- and post-biopsy questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: China OLIMPICS: China Ophthalmic Learning and Improvement Initiative in Cataract Surgery Trial
Status: COMPLETED
Conditions: Cataract
Interventions: OTHER: Simulation-based surgical training|OTHER: Standard surgical training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Recombinant Human Insulin Patch ZJSRM2021
Status: UNKNOWN
Conditions: type1diabetes|Type2 Diabetes
Interventions: DRUG: Recombinant Human Insulin Patch ZJSRM2021|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SKIP - A Double-blind Placebo-controlled Randomized Multicenter Trial of Skin Toxicity Treatment
Status: TERMINATED
Conditions: Colorectal Carcinoma
Interventions: DRUG: Panitumumab, Doxycycline/Placebo|DRUG: Panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of ACBT and Bubble Positive Expiratory Pressure Device in Asthmatic Patients
Status: RECRUITING
Conditions: Asthma
Interventions: OTHER: Active Cycle Breathing Technique|OTHER: Bubble Positive Expiratory Pressure Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Bimatoprost Compared With Latanoprost in Patients With Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Ocular Hypertension|Glaucoma
Interventions: DRUG: bimatoprost 0.03% eye drops|DRUG: latanoprost 0.005% eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RCT of BLT Implants Used for Immediate vs Early Placement, Restored With Ceramic Crowns on Titanium Bonding Bases.
Status: ACTIVE_NOT_RECRUITING
Conditions: Tooth Loss|Dental Implant, Single-tooth
Interventions: PROCEDURE: Timepoint of Implant placement of Bonelevel tapered implants|COMBINATION_PRODUCT: Material for tooth restoration - Lithiumdisilicate glass ceramic or zirconia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Catheter Ablation for Ventricular Tachycardia in Patients With an Implantable Cardioverter Defibrillator
Status: TERMINATED
Conditions: Ventricular Tachycardia
Interventions: DRUG: amiodarone|DRUG: sotalol|DEVICE: Biosense Webster's NAVI-STAR Thermo-Cool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Leflunomide Versus Sulfasalazine/Methotrexate in Rheumatoid Arthritis:an Ultrasound/Magnetic Resonance Imaging Study
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Methotrexate plus sulfasalazine|DRUG: Leflunomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Combining an Inferior Alveolar Nerve Block With a Buccal Infiltration
Status: COMPLETED
Conditions: Pulpitis
Interventions: DRUG: Inferior Alveolar Nerve Block|DRUG: Buccal Infiltration|COMBINATION_PRODUCT: Inferior Alveolar Nerve Block and Buccal Infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Assessment of Physical Exercise Using Stationary Bicycle for Pregnant Women With Risk for Preeclampsia Development
Status: COMPLETED
Conditions: Pre-eclampsia|Hypertension, Pregnancy-Induced|Pregnancy, High-Risk
Interventions: OTHER: Exercise using stationary bicycle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment of MDS/AML Patients With an Impending Hematological Relapse With AZA or ATA and Pevonedistat
Status: COMPLETED
Conditions: Acute Myeloid Leukemia in Remission|Myelodysplastic Syndromes|Minimal Residual Disease
Interventions: DRUG: Pevonedistat|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Education and Feedback Intervention to Reduce Inappropriate Transthoracic Echocardiograms
Status: UNKNOWN
Conditions: Inappropriate and Appropriate Transthoracic Echocardiograms
Interventions: BEHAVIORAL: Educational Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of SA-001 to Treat Pancreatic Exocrine Insufficiency
Status: COMPLETED
Conditions: Exocrine Pancreatic Insufficiency, Chronic Pancreatitis
Interventions: DRUG: SA-001|DRUG: SA-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reliability, Validity and Clinical Utility of a Robotic Assessment for Proprioception
Status: COMPLETED
Conditions: Neurological Diseases or Conditions|Sensory Disorders|Multiple Sclerosis|Stroke
Interventions: OTHER: Robotic assessment of finger proprioception
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Onartuzumab (MetMAb) in Combination With Bevacizumab (Avastin) Plus Platinum And Paclitaxel or With Pemetrexed Plus Platinum in Patients With Non-Squamous Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: Placebo|DRUG: RO5490258|DRUG: bevacizumab [Avastin]|DRUG: cisplatin/carboplatin|DRUG: paclitaxel|DRUG: pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacodynamic Profile of Oral 2101 in Secondary Raynaud's Disease
Status: COMPLETED
Conditions: Raynaud's Disease
Interventions: DRUG: SLx-2101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endodontic Treatment of Necrotic Primary Teeth With Guedes Pinto Paste: A Randomized Clinical Trial
Status: COMPLETED
Conditions: Endodontic Treatment of Primary Teeth
Interventions: DRUG: Endodontic treatment using Vitapex|DRUG: Endodontic treatment using Guedes Pinto
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effects of the "GameDay Ready" Behavioral Weight Management Program for Black Men Living in the Rural South
Status: RECRUITING
Conditions: Obesity
Interventions: BEHAVIORAL: GameDay Ready|BEHAVIORAL: Walking and General Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Natural History Study of CEP290-Related Retinal Degeneration
Status: COMPLETED
Conditions: Blindness|Leber Congenital Amaurosis 10|Vision Disorders|Eye Diseases|Eye Diseases, Hereditary|Eye Disorders Congenital|Retinal Disease|Retinal Degeneration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy, Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of Oral Administration of AIM-102 in Patients With Mild to Moderate Allergic Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: AIM-102, D-cyclohexylalanine-D-glutamic-glycine tripeptide|DRUG: Buffered Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Compound Xiwujia Granules Treat Chronic Fatigue Syndrome
Status: NOT_YET_RECRUITING
Conditions: Chronic Fatigue Syndrome
Interventions: DRUG: Compound Xiwujia granule + Guipi granule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of Sulthiame in Patients With Obstructive Sleep Apnea (OSA)
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: Sulthiame
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label follow-on Trial to Assess the Long-term Safety and Efficacy of Oral SPM 927 in Subjects With Diabetic Neuropathy
Status: COMPLETED
Conditions: Painful Diabetic Neuropathy
Interventions: DRUG: SPM927/Lacosamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperalgesia in Methadone Patients: Can it be Treated?
Status: UNKNOWN
Conditions: Opioid-induced Hyperalgesia
Interventions: DRUG: dextromethorphan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT