pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Describing the Effects of Insoles in Children With Increased Femoral Anteversion and Pes Planovalgus
Status: COMPLETED
Conditions: Femoral Anteversion|Pes Planovalgus|Flat Foot
Interventions: DEVICE: Insole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SURVEILLE-HPV: Evaluation of HPV16 Circulating DNA as Biomarker to Detect the Recurrence, in Order to Improve Post Therapeutic Surveillance of HPV16-driven Oropharyngeal Cancers
Status: RECRUITING
Conditions: Oropharynx Squamous Cell Carcinoma
Interventions: BIOLOGICAL: HPV16 Ct-DNA dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: NOVOCART®3D for Treatment of Articular Cartilage of the Knee
Status: ACTIVE_NOT_RECRUITING
Conditions: Articular Cartilage of the Femoral Condyle Between 2-6cm2
Interventions: PROCEDURE: Microfracture|BIOLOGICAL: NOVOCART 3D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neo-adjuvant Immunochemotheray Versus Neo-adjuvant Chemotherapy for Resectable Esophageal Carcinoma
Status: RECRUITING
Conditions: Esophageal Cancer|Surgery|Neoadjuvant Treatment|Survival
Interventions: DRUG: Neoadjuvant immunochemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study to Evaluate a New Energy Storage and Return Prosthetic Foot
Status: COMPLETED
Conditions: Lower Limb Amputation Below Knee (Injury)|Lower Limb Amputation Above Knee (Injury)|Lower Limb Amputation Knee
Interventions: DEVICE: Revo-M|DEVICE: Taleo|DEVICE: Proflex XC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment
Status: RECRUITING
Conditions: Advanced or Metastatic Solid Tumor|Liver Failure
Interventions: DRUG: Sacituzumab Govitecan-hziy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Postconditioning in Patients With Acute Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention (PCI)
Status: COMPLETED
Conditions: Myocardial Reperfusion Injury|Myocardial Ischemia|Myocardial Infarction
Interventions: PROCEDURE: Remote Postconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Apitox, Honeybee Toxin for Pain and Inflammation of Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: BIOLOGICAL: Apitox, purified honeybee toxin, lyophilized in saline|BIOLOGICAL: histamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Screen-and-treat Strategy for Vaginal Flora Abnormalities in Pregnant Women at High Risk of Preterm Birth
Status: NOT_YET_RECRUITING
Conditions: Bacterial Vaginosis|Vaginal Dysbiosis|Premature Delivery
Interventions: DIAGNOSTIC_TEST: Vaginal flora abnormalities screening and quantification using molecular biology technique|DRUG: Azithromycine|DRUG: Ceftriaxone|DRUG: Metronidazole|DRUG: Clotrimazole, Vaginal|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Recombinant SARS-CoV-2 Spike Protein Vaccine (CHO Cell) for the Prevention of COVID-19
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: ZR-202-CoV|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dopaminergic Neurotransmission in Schizophrenia, Patients at Risk and Healthy Subjects
Status: COMPLETED
Conditions: Schizophrenia
Interventions: PROCEDURE: IBZM-SPECT (bolus and constant infusion paradigm)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Determine the Effectiveness of Endoscopic Full-Thickness Plication for the Treatment of GERD
Status: TERMINATED
Conditions: Gastroesophageal Reflux Disease (GERD)
Interventions: DEVICE: NDO Full-thickness Plicator|DEVICE: Sham Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between the Supreme Laryngeal Mask Airway and the Laryngeal Tube Suction During Spontaneous Ventilation
Status: COMPLETED
Conditions: Adverse Anesthesia Outcome
Interventions: DEVICE: Laryngeal Tube Suction Disposable|DEVICE: Supreme Laryngeal Mask Airway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Addressing Antihypertensive Medication Adherence Through EHR-enabled Teamlets in Primary Care
Status: ACTIVE_NOT_RECRUITING
Conditions: Blood Pressure|Medication Adherence
Interventions: BEHAVIORAL: Electronic Health Record (EHR) Enabled Teamlets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label, Multicentre, Phase II/III RCT of PFLL Versus GP Combined With JS001 as the First-line Therapy for mNPC
Status: NOT_YET_RECRUITING
Conditions: Nasopharyngeal Carcinoma|Metastasis|Chemotherapy|Immunotherapy|Survival
Interventions: DRUG: Triprilimab(JS001)|DRUG: Cisplatin|DRUG: 5-Fluorouracil|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Trial To Assess The Safety And Pharmacokinetics Of Single, Ascending, Oral Doses Of Dimebon In Healthy Adults
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Dimebon|DRUG: Dimebon|DRUG: Dimebon|DRUG: Dimebon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Botanical Tincture for Symptoms of Irritable Bowel Syndrome
Status: NOT_YET_RECRUITING
Conditions: Irritable Bowel Syndrome Characterized by Constipation
Interventions: DRUG: Botanical Tincture|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Active Surveillance or Radical Treatment for Newly Diagnosed Patients With a Localized, Low Risk, Prostate Cancer START
Status: COMPLETED
Conditions: Prostatic Neoplasm
Interventions: OTHER: Active surveillance|PROCEDURE: Radical prostatectomy|RADIATION: Radiotherapy|PROCEDURE: Other radical treatments
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Does Vitamin D Supplementation Enhance Resolution of Inflammation After Community-acquired Pneumonia?
Status: COMPLETED
Conditions: Pneumonia
Interventions: DIETARY_SUPPLEMENT: Vitamin D3 supplementation|BIOLOGICAL: Peripheral blood and induced sputum sampling|RADIATION: Chest computerised tomography (CT) scans|OTHER: Symptom questionnaire|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Volume Effect of Hydrodissection for Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: PROCEDURE: Dextrose 1mL injection|PROCEDURE: Dextrose 2mL injection|PROCEDURE: Dextrose 4mL injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Confirmatory Study of MT-2412 in Japanese Patients With Type 2 Diabetes (Add-on Study of Teneligliptin)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Canagliflozin|DRUG: Teneligliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adapting and Assessing the Feasibility of a Diabetes Self-management Telehealth Intervention
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: BEHAVIORAL: Rural Diabetes One-Day Education and Care program (R-D1D)|BEHAVIORAL: Diabetes Education Materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Rapamycin Therapy in Head and Neck Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Mouth Neoplasms|Head and Neck Neoplasms|Tongue Neoplasms|Carcinoma, Squamous Cell
Interventions: DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: This Study Is To Determine If Inhaled Insulin Is Effective In Treating Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin glargine|DRUG: Inhaled Insulin (Exubera)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Care for Patients With Dementia
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: OTHER: transdisciplinary approach|OTHER: multidisciplinary approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study Assessing 13-valent Pneumococcal Conjugate Vaccine in Healthy Chinese Subjects
Status: COMPLETED
Conditions: Pneumococcal Infection
Interventions: BIOLOGICAL: 13-valent Pneumococcal Conjugate Vaccine|BIOLOGICAL: 13-valent Pneumococcal Conjugate Vaccine|BIOLOGICAL: 13-valent Pneumococcal Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Drug Concentrations in Breast Milk and Prediction of Blood Levels of the Breastfed Infants
Status: COMPLETED
Conditions: Breast Feeding
Interventions: DRUG: either of Atenolol, Bupropion, Brivaracetam, Escitalopram, Fluconazole, Lacosamide, Lamotrigine, Levetiracetam, Methotrexate or Ezetimibe
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Physiological Responses in Robotic Neurorehabilitation
Status: UNKNOWN
Conditions: Interventional Study
Interventions: OTHER: Robotic Treatment|OTHER: Conventional Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of SLS009 (Formerly GFH009) a Potent Highly Selective CDK9 Inhibitor in Patients With Hematologic Malignancies
Status: RECRUITING
Conditions: Hematologic Malignancies
Interventions: DRUG: SLS009|DRUG: venetoclax|DRUG: azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-MART-1 F5 Cells Plus ALVAC MART-1 Vaccine to Treat Advanced Melanoma
Status: TERMINATED
Conditions: Metastatic Melanoma|Skin Cancer
Interventions: BIOLOGICAL: autologous anti-MART-1 F5 T-cell receptor gene-engineered peripheral blood lymphocytes|BIOLOGICAL: ALVAC MART-1 Vaccine|BIOLOGICAL: aldesleukin|DRUG: cyclophosphamide|DRUG: fludarabine phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home-based Complex Intervention for Children With Ataxia Telangiectasia
Status: RECRUITING
Conditions: Ataxia Telangiectasia in Children|Ataxia Telangiectasia
Interventions: OTHER: Whole-body exercise and respiratory exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Controlled Study of the Ability of a Smokefree Tobacco Product to Increase the Quit Rate Among Cigarette Smokers
Status: COMPLETED
Conditions: Cigarette Smoking
Interventions: DRUG: Low-nitrosamine smokefree tobacco product for oral use|OTHER: Non-tobacco, non-nicotine placebo product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility Trial of Adipose-Derived Regenerative Cells in the Treatment of Chronic Myocardial Ischemia
Status: COMPLETED
Conditions: Myocardial Ischemia
Interventions: DEVICE: ADRCs processed by the Celution System|DEVICE: Placebo Comparator: Lactated Ringer's and Subject's Blood
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NiPPeR Randomised Trial - Child Follow Up Study
Status: ENROLLING_BY_INVITATION
Conditions: Obesity, Childhood|Cognition|Neurobehavioral Manifestations|Metabolic Disturbance|Growth Disorders|Allergy|Atopic Dermatitis|Atopy|Nutrition, Healthy|Lifestyle|Microbial Colonization|Breastfeeding
Interventions: OTHER: Intervention (Study Nutritional Drink)|OTHER: Control (Standard Nutritional Drink)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: RE-SEARCH Study: A Study to Learn How and in Which Amount Regorafenib is Given in Usual Practice to Patients in Spain: a Study Looking Back at Cases That Have Already Happened When the Study Begins.
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combining Lidocaine and Ropivacaine for an Infraclavicular Brachial Plexus Nerve Block
Status: RECRUITING
Conditions: Nerve Block|Anesthesia, Local|Forearm Fracture|Surgery|Brachial Plexus Block
Interventions: DRUG: Ropivacaine 0.5% Injectable Solution|DRUG: Lidocaine epinephrine|DRUG: Ropivacaine 0.75% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Slings With Vesico-Vaginal Fistula Repair
Status: UNKNOWN
Conditions: Vesicovaginal Fistula
Interventions: PROCEDURE: Pubococcygeus sling|PROCEDURE: Rectus fascia sling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Putative Investigational Therapeutics in the Treatment of Patients With Known Ebola Infection
Status: COMPLETED
Conditions: Ebola Virus Infection
Interventions: DRUG: B/Current Standard of Care Plus ZMapp|OTHER: A/Current Standard of Care Alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Test a Marketed Drug in the Treatment of Menstrual Migraine (0462-072)
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: MK0462, rizatriptan benzoate / Duration of Treatment -1day|DRUG: Comparator: placebo / Duration of Treatment - 1 day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Chronic Hepatitis C Virus (HCV) Infection in Cirrhotic Adults With Genotype 1b (GT1b) Infection
Status: COMPLETED
Conditions: Chronic Hepatitis C Virus (HCV) Infection
Interventions: DRUG: Ombitasvir/Paritaprevir/Ritonavir|DRUG: Dasabuvir|DRUG: Ribavirin (RBV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Loss of Response of Adalimumab Biosimilar vs Adalimumab Original, in Inflammatory Bowel Disease.
Status: TERMINATED
Conditions: Crohn Disease|Ulcerative Colitis
Interventions: DRUG: Amgevita 40Mg Solution for Injection|DRUG: HUMIRA 40Mg Solution for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Bioavailability of Different Formulations of AZD9977 and Dapagliflozin and Influence of Food in Selected Formulations in Healthy Volunteers
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Treatment A|DRUG: Treatment B|DRUG: Treatment C|DRUG: Treatment D|DRUG: Treatment E|DRUG: Treatment F|DRUG: Treatment G|DRUG: Treatment H
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Asthma Inflammation Research
Status: ENROLLING_BY_INVITATION
Conditions: Asthma|Allergic Asthma|Non-allergic Asthma
Interventions: DIETARY_SUPPLEMENT: Nutritional approach for asthma|DIETARY_SUPPLEMENT: Low Caloric Shake|BIOLOGICAL: whole lung allergen challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study on the Pain Control Effect of the Anesthetic Method During Prostate Biopsy: Comparison Between Pelvic Plexus Block and Periprosthetic Nerve Block
Status: UNKNOWN
Conditions: Transrectal Systematic Prostate Biopsy Related Pain
Interventions: PROCEDURE: Pelvic plexus block|PROCEDURE: Periprostatic nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Usefulness of Non-invasive Radiofrequency Therapy for Facial Contouring
Status: COMPLETED
Conditions: Subcutaneous Fat
Interventions: PROCEDURE: Noninvasive Radiofrequency TruSculpt
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Two Dosing Schedules of Atezolizumab in Combination With Gemcitabine and Cisplatin as First-Line Treatment for Metastatic Bladder Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Urothelial Carcinoma|Locally Advanced|Unresectable
Interventions: DRUG: Atezolizumab|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Establishment of Online Registration Platform for Unruptured Intracranial Aneurysms Based on Regional Medical Centers in China and Population Follow-up Study (Phase Ⅱ)
Status: RECRUITING
Conditions: Intracranial Aneurysm
Interventions: OTHER: Obervation|OTHER: Obervation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comparison the Intubation of a Left Sided Double Lumen Tube and Uniblocker
Status: COMPLETED
Conditions: Therapeutic Procedural Complication
Interventions: DEVICE: Uniblocker|DEVICE: Left-sided Double-lumen Tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effectiveness of APP Intervention on Home Self-care Ability and Quality of Life of Patients With Intestinal Stoma
Status: UNKNOWN
Conditions: Quality of Life|Mobile Apps|Ostomy
Interventions: OTHER: A new APP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Driving Simulation to Assess Non-Sedative Effects of Tolperisone
Status: COMPLETED
Conditions: Driving Impaired
Interventions: DRUG: Cyclobenzaprine 10 Mg Oral Tablet|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fetal Surgery Interview Study: Parental Perceptions of Fetal Surgery
Status: RECRUITING
Conditions: Fetal Surgery|Myelomeningocele|Congenital Diaphragmatic Hernia
Interventions: OTHER: In-depth interview
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: RTA 408 Capsules in Patients With Mitochondrial Myopathy - MOTOR
Status: COMPLETED
Conditions: MItochondrial Myopathies
Interventions: DRUG: Omaveloxolone capsules, 2.5 mg|DRUG: omaveloxolone capsules, 5 mg|DRUG: omaveloxolone capsules, 10 mg|DRUG: Placebo capsules|DRUG: omaveloxolone capsules, 20 mg|DRUG: omaveloxolone capsules, 40 mg|DRUG: omaveloxolone capsules, 80 mg|DRUG: omaveloxolone capsules, 160 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intratumoral Administration of Daromun in Non-melanoma Skin Cancer Patients
Status: RECRUITING
Conditions: Carcinoma, Basal Cell|Carcinoma, Cutaneous Squamous Cell
Interventions: DRUG: L19IL2 +L19TNF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemoradiotherapy After Surgery Versus Preoperative Chemoradiotherapy for Stage II/III Mid-low Rectal Cancer With or Without High-risk Factors
Status: NOT_YET_RECRUITING
Conditions: Radiotherapy
Interventions: PROCEDURE: chemoradiotherapy after surgery|OTHER: High-risk Factors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Gestational Diabetes Management Based on Planned Behavior Theory
Status: COMPLETED
Conditions: Diabetes Mellitus, Gestational
Interventions: BEHAVIORAL: Gestational Diabetes Training Intervention based on Planned Behavior Theory|BEHAVIORAL: Gestational Diabetes Training Intervention based on standart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine Surgery
Status: RECRUITING
Conditions: Spinal Fusion|Spinal Stenosis|Spondylolisthesis
Interventions: DRUG: with U-VANCO (vancomycin hydrochloride)|DRUG: without U-VANCO (vancomycin hydrochloride)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: BD OneFlow CLPD Panel (BD OneFlow LST, and B-CLPD T1 to T4 Assays) on the BD FACSLyric System.
Status: COMPLETED
Conditions: Chronic Lymphoproliferative Diseases (CLPD)
Interventions: DIAGNOSTIC_TEST: BD OneFlow LST, and B-CLPD T1 to T4 Assays
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Using of Testes Shocker in Improving the Spermatogenesis and Sperms Activity
Status: RECRUITING
Conditions: Infertility, Male|Infertility Unexplained|Infertility Due to Complete Spermatogenic Arrest|Oligospermia|Asthenozoospermia|Necrospermia
Interventions: DEVICE: Testes shocker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changing Susceptible Body Constitution for COVID-19 Prevention by Chinese Medicine in Hong Kong Residents
Status: UNKNOWN
Conditions: COVID19|Herbal Medicine
Interventions: DRUG: Yu-Ping-Feng formula|DRUG: Xiang-Sha-Liu-Jun formula|DRUG: Liu-Wei-Di-Huang formula|DRUG: Placebo for "Deficiency of Qi and Yang"|DRUG: Placebo for "Deficiency of Qi and Yin"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Are EMS Personnel Prepared to Identify and Decompression of Tension Pneumothorax
Status: UNKNOWN
Conditions: Tension Pneumothorax
Interventions: DEVICE: ThoraQuik atraumatic set for pneumothorax decompression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Adjuncts for Adductor Block: Dexamethasone,Dexmedetomidine, or Combination to Reduce Pain
Status: RECRUITING
Conditions: ACL Injury
Interventions: DRUG: Dexamethasone 4mg|DRUG: Dexmedetomidine|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison Between a Long Term and a Conventional Maintenance Treatment With Rituximab
Status: COMPLETED
Conditions: ANCA-associated Vasculitides
Interventions: DRUG: rituximab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Danlou Tablets to Prevent Left Ventricular Remodeling
Status: COMPLETED
Conditions: Left Ventricular Remodeling|Acute Myocardial Infarction
Interventions: DRUG: Danlou Tablets|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Administration of Fostamatinib on Blood Concentrations of Warfarin in Healthy Subjects
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Healthy Subjects
Interventions: DRUG: warfarin|DRUG: fostamatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Eribulin in Combination With Anti-PD-1 Antibody in Patients With Metastatic Triple-Negative Breast Cancer
Status: UNKNOWN
Conditions: TNBC - Triple-Negative Breast Cancer
Interventions: DRUG: Eribulin|DRUG: anti-PD-1 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pediatric Research on Improving Speed, Memory and Attention
Status: UNKNOWN
Conditions: Brain Tumors
Interventions: OTHER: Neurofeedback|OTHER: Placebo feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-Oxidant Effect on Peritoneal Membrane in Peritoneal Dialysis (PD) Patients
Status: UNKNOWN
Conditions: End-Stage Kidney Disease|Peritoneal Dialysis
Interventions: DRUG: N-acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 10 mg Donepezil Hydrochloride Orally Disintegrating Tablets Under Fasting Conditions.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Donepezil Hydrochloride|DRUG: Aricept®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose:
Clinical trial: Measles Vaccine in Patients With Measles Virus-Positive, Advanced Non-Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-Small Cell Lung Cancer|Measles
Interventions: BIOLOGICAL: attenuated measles vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study In Adults And Adolescents With Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Hayfever|Rhinitis, Allergic, Seasonal|Seasonal Allergic Rhinitis
Interventions: DRUG: fluticasone furoate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Transfusion-Induced Alterations of Pulmonary and Immune Function in Mechanically Ventilated Patients
Status: COMPLETED
Conditions: Pulmonary Edemas|Blood Protein Disorders
Interventions: OTHER: RBC transfusion of 5 days or less storage age|OTHER: RBC transfusion of conventional storage age
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Comparison of Electrical Ilioinguinal Nerve Stimulation With Intravesical Irrigation for Bladder Pain Syndrome
Status: COMPLETED
Conditions: Painful Bladder Syndrome
Interventions: DEVICE: Electrical ilioinguinal nerve stimulation|PROCEDURE: Intravesical Irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Oral Hyaluronic Acid in Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DIETARY_SUPPLEMENT: A+HA(tm)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Administration of Prothrombin Concentrate Complex in Patients With Acute Hemorrhage Following Severe Trauma
Status: COMPLETED
Conditions: Shock, Hemorrhagic
Interventions: DRUG: Pro-Thrombin Concentrate Complex|DRUG: NaCl 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Love Together, Parent Together: A Protocol for a Pilot Study of an Intervention for Interparental Couples With Young Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Interparental Conflict|Marital Conflict|Marital Relationship|Internet-Based Intervention|Family Conflict
Interventions: BEHAVIORAL: Love Together, Parent Together (L2P2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Stent Implantation of Polyurethane Expandable Valve, by Catheter, in Patients With Pulmonary Valve Dysfunction
Status: UNKNOWN
Conditions: Valvulopathy
Interventions: DEVICE: Polyurethane expandable valve stent implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Tepotinib Drug-Drug Interaction Study With Itraconazole in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tepotinib (HydroChloride hydrate)|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeting Insomnia to Improve Outcomes in Adults With Problematic Cannabis Use
Status: RECRUITING
Conditions: Insomnia
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for insomnia (CBTi-CB-TM)|BEHAVIORAL: Sleep Hygiene Education (SHE-TM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Randomized Controlled Trial Comparing Two Different Morcellators for HoLEP Procedures
Status: COMPLETED
Conditions: Benign Prostatic Hypertrophy Requiring Surgical Intervention
Interventions: DEVICE: Lumenis VersaCut Morcellator|DEVICE: Wolf Piranha Morcellator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rotational Thromboelastometry Guided Blood Component Use in Children With Cirrhosis Undergoing Invasive Procedures: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Cirrhosis, Liver
Interventions: PROCEDURE: Rotational Thromboelastometry to guide blood product transfusion pre invasive procedure|PROCEDURE: Conventional transfusion methods to guide blood product transfusion pre invasive procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effectiveness of JNJ 40929837 for the Treatment of Asthma Using a Bronchial Allergen Challenge Model
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: JNJ 40929837|DRUG: Placebo|DRUG: Montelukast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study for the Treatment of the Bone Marrow Edema:Core Decompression VS Bone Marrow Concentrate (BMC) VS Bone Substitute
Status: TERMINATED
Conditions: Bone Marrow Edema
Interventions: BIOLOGICAL: autologous bone marrow concentrate|BIOLOGICAL: bone substitute i-FactorTM|PROCEDURE: core decompression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Craniosacral Therapy vs Pelvic Floor Physical Therapy
Status: UNKNOWN
Conditions: Multiple Sclerosis|Bladder Dysfunction|Urinary Incontinence|Overactive Bladder
Interventions: PROCEDURE: Pelvic Floor Physical Therapy|PROCEDURE: Craniosacral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Blood Glucose Monitoring on Behavior Change in Type 2 Diabetes
Status: ENROLLING_BY_INVITATION
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Self-regulation health education|BEHAVIORAL: Usual diabetes health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prevention of Developmental Delay and Xylitol (PDDaX) Study
Status: RECRUITING
Conditions: Prematurity|Neurodevelopmental Disorders
Interventions: DIETARY_SUPPLEMENT: Maternal Use of Xylitol Chewing Gum During Pregnancy|DIETARY_SUPPLEMENT: No Maternal Xylitol Chewing Gum Use During Pregnancy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: "Phospholipovit" vs Placebo in Patients With Combined Hyperlipidemia
Status: COMPLETED
Conditions: Combined Hyperlipidemia
Interventions: DRUG: "Phospholipovit"|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness-based Cognitive Coping for ADRD Caregivers
Status: ACTIVE_NOT_RECRUITING
Conditions: Caregiver Stress
Interventions: BEHAVIORAL: Mindfulness-based Cognitive Coping|BEHAVIORAL: Traditional Educational/Resources Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Immunogenicity and Safety Study of Heterologous Booster Vaccination of a SARS-CoV-2 Recombinant Protein Nanoparticle Vaccine(GBP510) Adjuvanted With AS03 in Adults Aged 18 Years and Older
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: GBP510 adjuvanted with AS03|OTHER: Placebo (Normal Saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Aerobic Exercise Training on Vascular, Cardiac and Cerebral Vascular Function in COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Individualized, non-linear aerobic exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-Discharge Pharmacist-led Rapid Medication Optimization for Heart Failure (Post-Discharge PHARM-HF)
Status: RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction HFrEF
Interventions: OTHER: Pharmacist co-management of HFrEF medication optimization|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluate Safety and Pharmacokinetic To Assess Bronchopulmonary Disposition of Intravenous Delafloxacin in Healthy Adults
Status: COMPLETED
Conditions: Pneumonia
Interventions: DRUG: Delafloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Visilizumab for Moderate to Severe Inflammatory, Nonstricturing, Nonpenetrating Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: Visilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Further Development and Initial Testing of RESTORE in Frontline Workers
Status: COMPLETED
Conditions: Mental Health|PTSD|Anxiety|Depressive Symptoms
Interventions: BEHAVIORAL: RESTORE: Recovering from Extreme Stressors Through Online Resources and E-health
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Single Dose Evaluation of the Effects of Renal Impairment on Deflazacort Pharmacokinetics
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Deflazacort
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lenalidomide and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Recurrent Adult Acute Myeloid Leukemia
Interventions: DRUG: cytarabine|DRUG: lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 4-week Study of Mifepristone in the Prevention of Risperidone-induced Weight Gain in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Risperidone|DRUG: Mifepristone|DRUG: Risperidone-matched placebo|DRUG: Mifepristone-matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphoblastic Leukemia|B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|PROCEDURE: Biospecimen Collection|BIOLOGICAL: Blinatumomab|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Daunorubicin|DRUG: Daunorubicin Hydrochloride|DRUG: Dexamethasone|DRUG: Etoposide|PROCEDURE: Lumbar Puncture|DRUG: Mercaptopurine|DRUG: Methotrexate|DRUG: Pegaspargase|DRUG: Prednisone|BIOLOGICAL: Rituximab|DRUG: Vincristine|DRUG: Vincristine Sulfate|PROCEDURE: X-Ray Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Effectiveness of Utilizing Intraperitoneal Bupivacaine
Status: COMPLETED
Conditions: Laparoscopic Appendectomy
Interventions: DRUG: Bupivacaine|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Needleless Jet Injected (J-Tip) Lidocaine in Children Undergoing Regional Anesthesia Prior to Knee Arthroscopy
Status: COMPLETED
Conditions: Knee Injury
Interventions: DEVICE: J-Tip|DEVICE: Syringe and 25 gauge needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Investigate the Pharmacokinetic Drug Interactions Between Dutasteride and Tadalafil in Healthy Male Subjects
Status: COMPLETED
Conditions: Benign Prostate Hyperplasia
Interventions: DRUG: Tadalafil|DRUG: Dutasteride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Safety and Efficacy of Two Combinations of Isocitrate Dehydrogenase (IDH) Mutant Targeted Therapies Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) Harboring IDH Mutations Who Are Not Candidates to Receive Intensive Induction Chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: AG-120|DRUG: Azacitidine|DRUG: AG-221
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brief Mental Health First Aid Program (bMHFA) for Parents to Improve Mental Health Literacy in Low-Income Families: A Three-Arm Cluster Randomized Controlled Trial
Status: RECRUITING
Conditions: Mental Health Issue
Interventions: OTHER: Brief Mental Health First Aid Workshop|OTHER: Semi-structured interviews
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Endoscopic Management Of Iatrogenic Esophageal Perforation After Laparoscopic Upper Gastrointestinal Surgery
Status: COMPLETED
Conditions: Iatrogenic Esophageal Perforation
Interventions: PROCEDURE: endoscopic repair of iatrogenic esophageal perforation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IL-1RA Treatment in Patients With Acute ACL Tear and Painful Effusions
Status: TERMINATED
Conditions: Anterior Cruciate Ligament Tear
Interventions: DRUG: anakinra (150mg)|OTHER: Saline intraarticularly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Parenting Intervention for Mothers With Substance Use Disorder
Status: NOT_YET_RECRUITING
Conditions: Substance Use Disorders|Children of Mothers With Substance Use Disorders
Interventions: BEHAVIORAL: THRIVE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: BEL114333, a Continuation Study of BEL113750 in Subjects With Systemic Lupus Erythematosus (SLE) in Northeast Asia, and in Japan Subjects Completing the Open-label Extension of HGS1006-C1115
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Belimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BIBR 1048 Dose Range Finding Study in Prevention of Venous Thromboembolism in Patients With Primary Elective Total Hip or Knee Replacement Surgery
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DRUG: Enoxaparin|DRUG: BIBR 1048|DRUG: BIBR 1048|DRUG: BIBR 1048|DRUG: BIBR 1048
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Autologous T Cell Vaccine (TCV) for Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing-Remitting Multiple Sclerosis
Interventions: BIOLOGICAL: Tovaxin Autologous T cell vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patients With Relapsed or Refractory Diffuse Large B Cell Non Hodgkin Lymphomas
Status: TERMINATED
Conditions: Non-Hodgkin Lymphomas
Interventions: DRUG: Ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of Ixabepilone in Combination With Capecitabine in Japanese Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Ixabepilone|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Home-based Parenting Support Program: Parenting Young Children
Status: RECRUITING
Conditions: Intellectual Disability|Attention Deficit Hyperactivity Disorder|Autism Spectrum Disorder
Interventions: BEHAVIORAL: Parenting Young Children|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Efavaleukin Alfa in Participants With Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Efavaleukin Alfa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate Dietary Modification in Patients With Functional Dyspepsia.
Status: WITHDRAWN
Conditions: Dyspepsia|Dietary Modification
Interventions: BEHAVIORAL: Low FODMAP Diet|BEHAVIORAL: Choose My Plate Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT