pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluating the Efficacy of Dual Layer Amniotic Membrane (Artacent®)
Status: RECRUITING
Conditions: Chronic Diabetic Foot Ulcers
Interventions: BIOLOGICAL: Dual Layer Amniotic Membrane (DLAM). Artacent®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iron Status and Hypoxic Pulmonary Vascular Responses
Status: COMPLETED
Conditions: Lung Hypoxia|Pulmonary Arterial Hypertension|Iron Deficiency
Interventions: DRUG: Intravenous administration of ferric carboxymaltose|OTHER: Subacute hypoxic exposures
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Colchicine On Left Ventricle Function After Anterior Myocardial Infarction Assessed By Speckle Tracking
Status: COMPLETED
Conditions: Anterior MI|Colchicine
Interventions: DRUG: Colchicine 0.5 mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effective Dose of Statin Post PCI
Status: COMPLETED
Conditions: Statin Dose
Interventions: DRUG: moderate statin dose|DRUG: high dose statin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Pre-operative Measurements With Intraoperative Aberrometry in Predicting Correction for Low Toric Lens Correction in Cataract Surgery
Status: COMPLETED
Conditions: Cataract Surgery
Interventions: OTHER: Intraoperative Aberrometry vs preoperative biometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Real-time Anti-Factor Xa Measurements in Surgical Patients to Examine Enoxaparin Metabolism and Optimize Enoxaparin Dose
Status: COMPLETED
Conditions: Deep Venous Thrombosis|Pulmonary Embolus|Venous Thromboembolism
Interventions: DRUG: Real time enoxaparin dose adjustment|DRUG: Standard enoxaparin dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the DDI of DBPR108 With Metformin,Glibenclamide,Valsartan, or Simvastatin in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: DBPR108 tablets|DRUG: Metformin hydrochloride tablets|DRUG: Glibenclamide tablets|DRUG: Valsartan Capsules|DRUG: Simvastatin tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dislocated Stable Distal Both-Bone Forearm Fractures in Children
Status: UNKNOWN
Conditions: Fracture|Forearm|Distal|Child|Treatment
Interventions: PROCEDURE: Kirschner-wires or not
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Preliminary Anti-Tumor Activity of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors With FGFR3 Gene Alterations
Status: RECRUITING
Conditions: Locally Advanced Urothelial Carcinoma|Metastatic Urothelial Carcinoma|Solid Tumor|Urothelial Carcinoma|Solid Tumor, Adult|Bladder Cancer|Non-muscle-invasive Bladder Cancer|FGFR3 Gene Mutation|FGFR3 Gene Alteration|Advanced Solid Tumor|Advanced Urothelial Carcinoma|Urinary Tract Cancer|Urinary Tract Tumor|Urinary Tract Carcinoma
Interventions: DRUG: TYRA-300
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Normothermic Machine Perfusion (NMP) Versus Static Cold Storage (SCS) in Human Kidney Transplantation
Status: RECRUITING
Conditions: Kidney Transplant; Complications|Kidney Failure|Graft Dysfunction
Interventions: DEVICE: End-ischemic normothermic oxygenated machine perfusion|PROCEDURE: Static cold storage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of BDC-3042 as Single Agent and in Combination With Cemiplimab in Patients With Advanced Malignancies
Status: RECRUITING
Conditions: Triple Negative Breast Cancer|Clear Cell Renal Cell Carcinoma|Ovarian Cancer|Head and Neck Cancer|Colorectal Cancer|Non-small Cell Lung Cancer|Melanoma
Interventions: DRUG: BDC-3042|DRUG: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dapagliflozin in Patients With Atrial Fibrillation (DAPA-AF)
Status: RECRUITING
Conditions: Diabetes Mellitus|Atrial Fibrillation
Interventions: DRUG: Dapagliflozin 10Mg Tab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TNS for Treating Nicotine Craving
Status: UNKNOWN
Conditions: Nicotine Craving
Interventions: DEVICE: TRIGEMINAL NERVE STIMULATION (TNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-tumoral Ipilimumab Plus Intravenous Nivolumab Following the Resection of Recurrent Glioblastoma
Status: UNKNOWN
Conditions: Glioblastoma
Interventions: DRUG: Ipilimumab (YervoyTM, 50 mg/10 mL solution)|DRUG: Nivolumab (OpdivoTM, 40 mg/4mL solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualization of Ovarian Stimulation Using AMH Maximizes the Benefits and Minimizes Complications and Risks
Status: COMPLETED
Conditions: Infertility
Interventions: OTHER: conventional ovarian stimulation|OTHER: individualized ovarian stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study Evaluating the Safety, Tolerability, and Initial Efficacy of JWK008 in Patients With Mucopolysaccharidosis Type I
Status: RECRUITING
Conditions: Mucopolysaccharidosis Type I
Interventions: GENETIC: JWK008 Single intravenous infusion administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Quality-of-Life Improvements Using UroShield Device
Status: RECRUITING
Conditions: Quality of Life|Catheter-Associated Urinary Tract Infection
Interventions: DEVICE: Active UroShield|DEVICE: Sham UroShield
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Hamstring Injury (HAMIR) Index
Status: ENROLLING_BY_INVITATION
Conditions: Hamstring Injury
Interventions: OTHER: Patient Reported Outcomes Surveys|OTHER: Clinical Assessments|OTHER: Biomechanical and Neuromuscular Assessments|DEVICE: Conventional MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetics of Resveratrol Comprising Products
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: RGC|DIETARY_SUPPLEMENT: RGC|DIETARY_SUPPLEMENT: Resveratrol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Zanubrutinib in Combination With Obinutuzumab (ZO) for Newly Diagnosed Follicular Lymphoma
Status: RECRUITING
Conditions: Follicular Lymphoma|Newly Diagnosed
Interventions: DRUG: Zanubrutinib combined with Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Disinfective Solution as an Adjunct to Maintenance Therapy of Inflamed Periodontal Pockets
Status: TERMINATED
Conditions: Chronic Periodontitis
Interventions: PROCEDURE: Scaling and root planing|PROCEDURE: Scaling and root planing with solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Radiotherapy Combined With Apatinib Mesylate in the Treatment of Rhabdomyosarcoma in Children
Status: UNKNOWN
Conditions: Childhood Rhabdomyosarcoma
Interventions: DRUG: Apatinib mesylate tablets|RADIATION: Three-dimensional conformal intensity modulation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Observational Program Using Digital Technology Tools to Enhance Patient Adherence to Omacor Therapy
Status: COMPLETED
Conditions: History of Myocardial Infarction|Hypertriglyceridemia
Interventions: DRUG: Omacor (Omega-3-acid ethyl esters)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pulmozyme in Cystic Fibrosis With Sinusitis
Status: WITHDRAWN
Conditions: Sinusitis|Cystic Fibrosis
Interventions: DRUG: Pulmozyme single use ampule|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ampicillin/Sulbactam Versus Cefuroxime as Antimicrobial Prophylaxis for Cesarean Section
Status: COMPLETED
Conditions: Surgical Site Infections
Interventions: DRUG: Ampicillin-sulbactam|DRUG: Cefuroxime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Casopitant And ZOFRAN To Prevent Post Operative Nausea And Vomiting In Women
Status: COMPLETED
Conditions: Nausea and Vomiting, Postoperative|Postoperative Nausea and Vomiting
Interventions: DRUG: casopitant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Single-blind Stepped Wedge Cluster Randomized Controlled Behaviour Change Trial to Determine Effectiveness of Prevention Programme of Melioidosis in Diabetics in Ubon Ratchathani, Northeast Thailand
Status: COMPLETED
Conditions: Melioidosis
Interventions: OTHER: An educational programme for prevention of melioidosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: FES Imaging to Optimize Tamoxifen for Metastatic Breast Cancer
Status: RECRUITING
Conditions: ERα+ Breast Cancer|ESR1 Gene Mutation
Interventions: DRUG: Tamoxifen|DIAGNOSTIC_TEST: FES PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Omega-3 Fatty Acids in Maintaining Optimal Mental Health in Elderly People
Status: COMPLETED
Conditions: Cognitive Impairment|Depression
Interventions: BEHAVIORAL: n-3 Fatty Acid Supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ADORE: Efficacy of DORavirine in Adults Living With HIV Experiencing Virological Failure on First-line Efavirenz-based Antiretroviral Therapy With NNRTI Resistance
Status: UNKNOWN
Conditions: HIV-1-infection
Interventions: DRUG: Doravirine/Lamivudine/Tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Furosemide to Prevent Fluid Overload During Red Blood Cell Transfusion in Neonates
Status: UNKNOWN
Conditions: Lung Disease
Interventions: DRUG: Furosemide|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of JTT-654 in Type 2 Diabetic Patients
Status: TERMINATED
Conditions: Type II Diabetes Mellitus
Interventions: DRUG: JTT-654|DRUG: JTT-654 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Core Strengthening and PNF Pattern on Static Balance and Plantar Pressure in Chronic Stroke Patients
Status: COMPLETED
Conditions: Chronic Stroke
Interventions: OTHER: Routine Physical Therapy|OTHER: Routine Physical Therapy+ PNF and Core Stregthening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pragmatic Factorial Trial of Hydroxychloroquine, Azithromycin, or Both for Treatment of Severe SARS-CoV-2 Infection
Status: TERMINATED
Conditions: SARS-CoV-2
Interventions: OTHER: Standard of care|DRUG: Hydroxychloroquine|DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Low and High Intensity Strategies to Maintain BP Control
Status: COMPLETED
Conditions: Hypertension
Interventions: OTHER: High Intensity Intervention|OTHER: Low Intensity Intervention|OTHER: All- 6 month pharmacist intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Non-Invasive Determination of Fetal Chromosome Abnormalities
Status: UNKNOWN
Conditions: Down Syndrome (Trisomy 21)|Edward's Syndrome (Trisomy 18)|Patau Syndrome (Trisomy 13)|Klinefelter Syndrome (47, XXY)|and Other Chromosome|Abnormalities.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Desmoteplase (International Nonproprietary Name [INN]) in Acute Ischemic Stroke (DIAS-2)
Status: COMPLETED
Conditions: Stroke, Acute
Interventions: DRUG: Desmoteplase|DRUG: Desmoteplase|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determination of the Optimal Approach to Select the Best Size of BASKA Mask to Use in Male Patients
Status: COMPLETED
Conditions: Determination of the Best Predictor for Correct Baska Mask Size
Interventions: DEVICE: Placement and use of Baska mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Kidney Transplant Study to Look at the Effects of Taking Fixed Doses of CellCept Versus Taking Doses of CellCept Based on the Concentration of CellCept in the Blood When Taking Full or Reduced Dose Calcineurin Inhibitors
Status: TERMINATED
Conditions: Kidney Transplantation|Delayed Graft Function
Interventions: DRUG: CellCept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel, Cisplatin, and Veliparib in Treating Patients With Advanced, Persistent, or Recurrent Cervical Cancer
Status: COMPLETED
Conditions: Cervical Adenocarcinoma|Cervical Adenosquamous Carcinoma|Cervical Squamous Cell Carcinoma, Not Otherwise Specified|Recurrent Cervical Carcinoma|Stage IVB Cervical Cancer AJCC v6 and v7
Interventions: DRUG: Cisplatin|OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ibrutinib With Rituximab in Relapsed or Refractory Mantle Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma, Mantle-Cell
Interventions: DRUG: Ibrutinib|DRUG: Lenalidomide|DRUG: Rituximab|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of CS-3150 Exposure on Corrected QT (QTc) Interval Duration in Healthy Volunteers
Status: COMPLETED
Conditions: Hypertension|Mineralocorticoid Receptor Antagonist
Interventions: DRUG: CS-3150|DRUG: Moxifloxacin|DRUG: Placebo matching moxifloxacin tablet|DRUG: Placebo matching CS-3150
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Individualized Sodium Management Versus Standard Treatment in Hemodialysis
Status: NOT_YET_RECRUITING
Conditions: End Stage Renal Disease
Interventions: DEVICE: Hemodialysis or Hemodiafiltration either with sodium zero-diffusive treatment or standard treatment without sodium-control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The CARO Study - Bioefficacy of Beta-Carotene in Oil and in a Mixed Diet in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: BEHAVIORAL: absorption and conversion of beta-carotene in human gastrointestinal (GI) tract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Methylphenidate ER Liquid Formulation in Adults With ASD and ADHD
Status: COMPLETED
Conditions: Attention-deficit/Hyperactivity Disorder|Autism Spectrum Disorder
Interventions: DRUG: Methylphenidate extended-release liquid formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of Topical GSK2981278 Ointment in Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: GSK2981278 0.03%|DRUG: GSK2981278 0.1%|DRUG: GSK2981278 0.8%|DRUG: GSK2981278 4%|DRUG: Vehicle|DRUG: Betamethasone valerate 0.1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double Blind, Placebo-controlled Topical Resiquimod Adjuvant for NY-ESO-1 Protein Vaccination
Status: COMPLETED
Conditions: Tumors
Interventions: DRUG: NY-ESO-1 protein; Montanide ISA®-51 VG; Resiquimod|DRUG: NY-ESO-1 protein; Montanide ISA®-51 VG; Resiquimod/placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of FBR-002 for the Treatment of Patients Hospitalized With COVID-19 in Need of Supplemental Oxygen and at Risk of Severe Outcome
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: FBR-002|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Anterior Hydrodilatation in Shoulder Adhesive Capsulitis
Status: COMPLETED
Conditions: Shoulder Capsulitis
Interventions: PROCEDURE: ultrasound-guided posterior hydrodilatation|DRUG: corticosteroid, saline, and local anesthetic|OTHER: guided stretching and strengthening exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Halotherapy in Children With Asthma
Status: COMPLETED
Conditions: Therapy, Oxygen Inhalation
Interventions: COMBINATION_PRODUCT: Halotherapy (Salt Therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hernia Repair Using the Totally ExtraPeritoneal (TEP) Laparoscopic Approach Without Curare and Without Orotracheal Intubation.
Status: RECRUITING
Conditions: Hernia, Inguinal
Interventions: PROCEDURE: Laparoscopic TEP hernia repair without curare and without orotracheal intubation.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Development of Open Heart Surgery Patient Care Protocol and Its Effect on Post-sternotomy Pain
Status: COMPLETED
Conditions: Heart; Surgery, Heart, Functional Disturbance as Result|Pain, Postoperative|Nursing Caries
Interventions: OTHER: Care Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Temozolomide Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Malignant Glioma or Recurrent CNS or Other Solid Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Childhood Germ Cell Tumor|Head and Neck Cancer|Kidney Cancer|Neuroblastoma|Ovarian Cancer|Sarcoma|Testicular Germ Cell Tumor
Interventions: BIOLOGICAL: filgrastim|DRUG: temozolomide|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Pain Relief in Laparoscopic Surgery
Status: COMPLETED
Conditions: Pain, Postoperative|Surgery
Interventions: PROCEDURE: Altered gas (86% CO2, 10% N2O, 4% O2)|PROCEDURE: Standardized gas (100% CO2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: 3-AP in Treating Patients With Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: triapine|OTHER: pharmacological study|PROCEDURE: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of TQ05105 Tablets in the Treatment of Moderate and High Risk Myelofibrosis
Status: UNKNOWN
Conditions: Moderate and High Risk Myelofibrosis
Interventions: DRUG: TQ05105 tablets|DRUG: Hydroxycarbamide tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Accelerated Radiotherapy and Concomitant Chemo-radiotherapy in HNSCC
Status: COMPLETED
Conditions: Oral Cancer|Oropharynx Cancer|Hypopharynx Cancer|Larynx Cancer
Interventions: PROCEDURE: Conventional radiotherapy 70 Gy in 7 weeks|PROCEDURE: middle accelerated radiotherapy 70 Gy in 6 weeks|PROCEDURE: very accelerated radiotherapy 64.8 Gy in 3.5 weeks|DRUG: 5FU, Paraplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sphenopalatine Ganglion Block for Post-Dural Puncture Headache in Orthopedic Patients
Status: UNKNOWN
Conditions: Sphenopalatine Ganglion Block|Adrenaline|Post-Dural Puncture Headache|Orthopedic|Randomized Controlled Study
Interventions: PROCEDURE: Sphenopalatine Ganglion Block|DRUG: Medical Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant CAPOXIRI Chemotherapy in the Treatment of Pancreatic Adenocarcinoma Protocol
Status: TERMINATED
Conditions: Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: Capecitabine, Oxaliplatin and Irinotecan (CAPOXIRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bioequivalence of Two Formulations of Biphasic Insulin Aspart 50 in Healthy Male Subjects
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: biphasic insulin aspart 50
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Peri-orbital and Peri-oral Wrinkle Reduction Trial
Status: TERMINATED
Conditions: Peri-orbital Wrinkles|Peri-oral Wrinkles
Interventions: DEVICE: Ulthera® System Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NEUWAVE Flex Microwave Ablation System in the Ablation of Primary Soft Tissue Lesions of the Lung
Status: TERMINATED
Conditions: Cancer of Lung|Cancer of the Lung|Lung Cancer|Neoplasms, Lung|Carcinoma, Non-Small Cell Lung|Non-Small Cell Lung Cancer|Non-Small-Cell Lung Carcinoma
Interventions: DEVICE: Microwave Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of the Combination of Umeclidinium (UMEC) and Vilanterol (VI) on Exercise Endurance Time (EET) in Participants With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: UMEC/VI DPI|DRUG: Placebo DPI|DRUG: Albuterol/salbutamol MDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RF Ablation of the Trigone for the Treatment of UUI
Status: SUSPENDED
Conditions: Urgent Urinary Incontinence
Interventions: DEVICE: selective bladder denervation using RF energy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Chewing a Calcium Supplement Before Fluoride Rinse on Salivary Fluoride
Status: COMPLETED
Conditions: Dental Caries
Interventions: DRUG: Inactive supplement|DRUG: Tricalcium phosphate supplement|DRUG: Calcium carbonate supplement|DRUG: Calcium citrate supplement|DRUG: Inactive supplement and fluoride mouthwash|DRUG: Calcium carbonate supplement and fluoride mouthwash|DRUG: Calcium citrate supplement and fluoride mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transdermal Patch for BupRenorphine Induction DurinG PrEgnancy (Patch BRIDGE)
Status: RECRUITING
Conditions: Opioid Use Disorder|Pregnancy Related|Pregnancy, High Risk|Pregnancy Complications|Buprenorphine Withdrawal
Interventions: DRUG: Buprenorphine Transdermal Matrix Patch|OTHER: Sham patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, 2-Part Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Multiple Doses of ASLAN003 in Healthy Elderly Subjects
Status: COMPLETED
Conditions: Healthy Elderly Subjects (Age ≥55 Years)
Interventions: DRUG: ASLAN003|DRUG: Matched Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy Therapy of Gemcitabine and Erbitux® to R0 or R1 Resected Pancreatic Cancer
Status: COMPLETED
Conditions: Adenocarcinoma
Interventions: DRUG: Cetuximab (Erbitux®) and Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Combined Exercise Program on Neuropathic Pain and Perceived Quality of Life in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Neuropathic Pain|Neuropathy, Diabetic
Interventions: OTHER: Combined Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of 2-weekly RAILIRI Versus FOLFIRI as Second-line Treatment in Advanced Colorectal Cancer Patients
Status: UNKNOWN
Conditions: Colorectal Carcinoma
Interventions: DRUG: Raltitrexed|DRUG: Irinotecan|DRUG: 5-fluorouracil|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Adipose-Derived Adult Stem Cell Transplantation for Corneal Diseases
Status: UNKNOWN
Conditions: Hereditary Corneal Dystrophy|Keratoconus
Interventions: PROCEDURE: Lipoaspiration|PROCEDURE: Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: De Novo Pilot Study, Lutonix Catheter in Conjunction With Bare Metal Stenting for Treatment of Coronary De Novo Lesions
Status: COMPLETED
Conditions: Coronary Artery Stenosis
Interventions: DEVICE: Lutonix Paclitaxel-Coated Balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A DDI Study to Assess the Effect of INC280 on the PK of Midazolam and Caffeine in Patients With cMET-dysregulated Advanced Solid Tumors
Status: COMPLETED
Conditions: cMET-dysregulated Advanced Solid Tumors
Interventions: DRUG: INC280|DRUG: Midazolam|DRUG: Caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cannabinoids in PLWHIV on Effective ART
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: TN-TC11M2 oral capsules (THC 2.5 mg/CBD 2.5 mg)|DRUG: TN-C200M2 oral capsules (CBD 200 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuramis® Deep Lidocaine Compared to YVOIRE® Volume Plus for Correction of Nasolabial Folds
Status: COMPLETED
Conditions: Nasolabial Folds
Interventions: DEVICE: experimental|DEVICE: comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Stem Cells in Improving Implantation Rates in ICSI Patients
Status: UNKNOWN
Conditions: Assess the Efficacy of Differentiated and Undifferentiated Stem Cell Therapy in Improving Endometrial Receptivity.
Interventions: BIOLOGICAL: Differentiated stem cells to endometrium is deposited in the uterine cavity through an IUI catheter|BIOLOGICAL: Undifferentiated MSC is deposited in the uterine cavity through an IUI catheter.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Neostigmine With Sugammadex on Postoperative Nausea and Vomiting.
Status: COMPLETED
Conditions: Incidence of Postoperative Nausea and Vomiting
Interventions: DRUG: Neostigmine|DRUG: sugammadex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial To Evaluate PF-05089771 On Its Own And As An Add-On Therapy To Pregabalin (Lyrica) For The Treatment Of Pain Due To Diabetic Peripheral Neuropathy (DPN)
Status: COMPLETED
Conditions: Diabetic Neuropathy, Painful
Interventions: DRUG: PF-05089771 150 mg|DRUG: Matched placebo for PF-05089771 150 mg and pregabalin 300 mg|DRUG: Pregabalin 300 mg|DRUG: PF-05089771 150 mg + Pregabalin 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Leucovorin and Fluorouracil With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: semaxanib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Investigation of Masseter and Temporalis Muscles Sections in Individuals With Temporomandibular Disorders
Status: UNKNOWN
Conditions: Temporomandibular Joint Disorders
Interventions: DEVICE: Determination muscles sections by Ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination Chemotherapy Plus Warfarin in Treating Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer|Thromboembolism
Interventions: DRUG: docetaxel|DRUG: doxorubicin hydrochloride|DRUG: estramustine phosphate sodium|DRUG: ketoconazole|DRUG: warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Clinical Study of TEAS Intervention in Relieving Anxiety Before Thoracoscopic Surgery
Status: RECRUITING
Conditions: Acupuncture Therapy|Preoperative Period|Anxiety|Thoracoscopic Surgery
Interventions: DEVICE: TEAS|DEVICE: Sham TEAS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pacemaker Effect With Closed Loop Sensor in Neuromodulated Syncope Refractory to Medical Therapy
Status: COMPLETED
Conditions: Syncope
Interventions: DEVICE: Pacemaker with Closed Loop Stimulation (CLS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: First-in-Human Single and Multiple Dose of GLPG2222
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG2222 single dose|DRUG: Placebo single dose|DRUG: GLPG2222 multiple doses|DRUG: Placebo multiple doses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravesical Prostatic Protrusion Mimicking Urothelial Cell Carcinoma of the Bladder
Status: UNKNOWN
Conditions: Bladder Cancer|Benign Prostatic Hyperplasia|Hematuria
Interventions: DIAGNOSTIC_TEST: Urethrocystoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Muscle Function and Effects of Repetitive Task Training in Patients With Inflammatory Myopaties
Status: UNKNOWN
Conditions: Idiopathic Inflammatory Myopathy|Dermatomyositis|Polymyositis
Interventions: OTHER: Resistance training|OTHER: Repetitive task training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Robotic Versus Conventional or Endoscopic Nipple Sparing Mastectomy in the Management of Breast Cancer-Prospective Study
Status: UNKNOWN
Conditions: Breast Cancer Female
Interventions: DEVICE: robotic assisted nipple sparing mastectomy|PROCEDURE: Endoscopic assisted nipple sparing mastectomy|PROCEDURE: Conventional nipple sparing mastectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Description of Compliance for the Daily Ventavis Use Via the Insight Program in Class III Pulmonary Arterial Hypertension Patients
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Ventavis (Iloprost, BAYQ6256)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial
Status: COMPLETED
Conditions: Hypertension|Atrial Fibrillation
Interventions: DEVICE: AF Suppression Pacing Algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flexible V/S Rigid Cystoscopy In Men With Urinary Tract Infection
Status: COMPLETED
Conditions: Lower Urinary Tract Symptoms
Interventions: DIAGNOSTIC_TEST: Diagnostic Flexible Cystosocpy|DIAGNOSTIC_TEST: Diagnostic Rigid Cystoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Mobile Transmission of Prehospital Vital Signs to the Emergency Department
Status: COMPLETED
Conditions: Telemedicine|Triage|Emergency Medical Service
Interventions: DEVICE: Real time transmission of patient related data. Device used: MobiMed 3.1, manufactured by Ortivus AB Sweden
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Randomized, Double-blinded Study of Treatment:Teriflunomide, in Radiologically Isolated Syndrome
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Teriflunomide 14 MG Oral Tablet [Aubagio]|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Extended Release Tacrolimus (Advagraf®) + Sirolimus (Rapamune®), Versus Extended Release Tacrolimus (Advagraf®) + Mycophenolate Mofetil in Kidney Transplant Patients
Status: COMPLETED
Conditions: Kidney Transplant Patients
Interventions: DRUG: A) TEST|DRUG: B) CONTROL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metacarpophalangeal Joint Reconstruction Using a Vascularized Cartilage and Bone Graft
Status: COMPLETED
Conditions: Volar Plate Injury, Thumb, Metacarpophalangeal Joint
Interventions: PROCEDURE: MCP joint
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Carboplatin, Nab-Paclitaxel and Pembrolizumab for Metastatic Triple-Negative Breast Cancer
Status: COMPLETED
Conditions: Metastatic Triple Negative Breast Cancer
Interventions: DRUG: Carboplatin|DRUG: Nab-paclitaxel|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TrEatment Approach in the Multimodal Era Registry
Status: RECRUITING
Conditions: Chronic Thromboembolic Pulmonary Hypertension|CTEPH
Interventions: PROCEDURE: Pulmonary endarterectomy|PROCEDURE: Balloon pulmonary angioplasty|DRUG: Pulmonary hypertension (PH)-specific medication
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Metformin Plus Megestrol Acetate as a Fertility-sparing Treatment in Patients With Atypical Endometrial Hyperplasia
Status: TERMINATED
Conditions: Atypical Endometrial Hyperplasia
Interventions: DRUG: Metformin plus Megestrol acetate|DRUG: Megestrol Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Ovarian Cystectomy Versus Aspiration and Coagulation in Ovarian Endometrioma
Status: COMPLETED
Conditions: Ovarian Endometrioma
Interventions: PROCEDURE: ovarian cystectomy|PROCEDURE: ovarian cyst aspiration and coagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Second Plecanatide Study In Irritable Bowel Syndrome With Constipation (IBS-C)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome Characterized by Constipation
Interventions: DRUG: Plecanatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intervening Early With Neglected Children
Status: UNKNOWN
Conditions: Conduct Disorder|ADHD|Depression
Interventions: BEHAVIORAL: Attachment and Biobehavioral Catch-up|BEHAVIORAL: Developmental Education for Families
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: RC48-ADC in Adjuvant/Salvage Treatment of HER2 Positive Non-muscle-invasive Bladder Cancer
Status: NOT_YET_RECRUITING
Conditions: Non-muscle Invasive Bladder Cancer
Interventions: DRUG: RC48-ADC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease
Status: UNKNOWN
Conditions: Crohn Disease
Interventions: DRUG: prednisolone|DIETARY_SUPPLEMENT: Alicalm (polymeric liquid formula)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Community Partnership to Examine Racial and Ethnic Differences in Health Care for Hypertension and Diabetes
Status: COMPLETED
Conditions: Hypertension|Diabetes Mellitis
Interventions: BEHAVIORAL: Medical Practice Improvement|BEHAVIORAL: Patient Education and Support|OTHER: Combination Intervention to Include Medical Practice Improvement and Patient Education and Support
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Oxaliplatin and Capecitabine in Treating Patients With Relapsed or Metastatic Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: capecitabine|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Benefit of Pipelle Biopsy in Patients With Postmenopausal Bleeding and an Atrophic-appearing Cavity
Status: COMPLETED
Conditions: Postmenopausal Bleeding|Endometrial Cancer|Endometrial Hyperplasia
Interventions: DEVICE: Pipelle biopsy catheter|DEVICE: Sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Testing the Safety and Efficacy of the Combination of the Antibody Pembrolizumab and Entinostat in Patients With Myelodysplastic Syndrome Who Are Not Responding to Hypomethylating Agents
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: Entinostat|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interleukin-2 (IL-2), Pegylated Interferon (PEG-IFN Alfa-2b), and Ribavirin (RBV) Treatment in Patients With Hepatitis C and HIV Coinfection
Status: COMPLETED
Conditions: HIV Infections|Hepatitis C
Interventions: DRUG: Ribavirin|DRUG: Aldesleukin|DRUG: Peginterferon alfa-2b
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Targeting Stress-Induced Alcohol Relapse Risk With Doxazosin XL
Status: WITHDRAWN
Conditions: Alcohol Use Disorder
Interventions: DRUG: Doxazosin XL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Intravenous Interleukin-4 PE38KDEL Cytotoxin in Treating Patients With Recurrent or Metastatic Kidney Cancer, Non-Small Cell Lung Cancer, or Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Kidney Cancer|Lung Cancer
Interventions: BIOLOGICAL: interleukin-4 PE38KDEL cytotoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effects of Trigger Point Treatment in Temporomandibular Joint Dysfunction
Status: COMPLETED
Conditions: Temporomandibular Joint Dysfunction
Interventions: OTHER: Ischemic compression|OTHER: Exercises (Rocabodo's 6x6 exercises and posture exercises)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Probiotics on Gastrointestinal Symptoms and on the Immune System in Patients With Systemic Sclerosis
Status: UNKNOWN
Conditions: Systemic Sclerosis|Scleroderma
Interventions: OTHER: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Metformin, Repaglinide or the Combination of Both in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: metformin|DRUG: repaglinide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Manipulation on Dysfunction of the Talo-crural Joint
Status: UNKNOWN
Conditions: Other Biomechanical Lesions|Talo-crural Joint Dysfunction
Interventions: OTHER: Chiropractic (HVLA) manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Bosentan in Patients With Diastolic Heart Failure and Secondary Pulmonary Hypertension
Status: COMPLETED
Conditions: Heart Failure, Diastolic|Hypertension, Pulmonary
Interventions: DRUG: bosentan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sentinel Lymph Node Mapping in Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Neoplasms
Interventions: OTHER: Endoscopic injection of 99mTc-sulfur colloid|OTHER: Endoscopic injection of ICG|OTHER: Endoscopic injection of Spot|PROCEDURE: Flexible sigmoidoscopy|PROCEDURE: Endoscopic NIR imaging and gamma probe|PROCEDURE: Dissection of sentinel lymph node(s)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Ranolazine in the Treatment of Pulmonary Hypertension Associated With Diastolic Left Ventricular Dysfunction
Status: COMPLETED
Conditions: Pulmonary Hypertension|Diastolic Left Ventricular Dysfunction
Interventions: DRUG: Ranolazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Variation In Success of Intravenous (IV) Placement With Observation Using New Techniques
Status: COMPLETED
Conditions: Catheterization|Peripheral Phlebotomy
Interventions: DEVICE: Veinviewer|DEVICE: Ultrasound|OTHER: Conventional technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE