pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Quantitative Ultrasound Biomarkers to Assess Upper Trapezius Muscles in Patients With Chronic Pain
Status: UNKNOWN
Conditions: Chronic Neck Pain
Interventions: DIAGNOSTIC_TEST: Quantitative Ultrasound|DIAGNOSTIC_TEST: Osteopathic TART Assessment|PROCEDURE: Osteopathic Manipulation Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Tolerability, Kinetics and Efficacy Study of Hoodia Gordonii Purified Extract (PYM50717)
Status: COMPLETED
Conditions: Appetite Depressant|Overweight|Body Weight
Interventions: OTHER: Hoodia gordonii purified extract (H.g.PE)|OTHER: Placebo yogurt drink|OTHER: Placebo yogurt drink|OTHER: Placebo yogurt drink|OTHER: Hoodia gordonii purified extract (H.g.PE)|OTHER: Hoodia gordonii purified extract (H.g.PE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Express LD to Treat Stenosed or Occlusive Atherosclerotic Disease in Iliac Arteries
Status: COMPLETED
Conditions: Arterial Occlusive Disease|Intermittent Claudication|Atherosclerotic Disease|Thrombosis
Interventions: DEVICE: stent implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quadratus Lumborum Block in Pediatric Patients
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Tramadol Hydrochloride|DRUG: Morphine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of Fingolimod in Pediatric Patients With Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: Interferon beta-1a|DRUG: Fingolimod|DRUG: Placebo capsule|DRUG: Placebo i.m. injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Cervical Ripening in the Outpatient Setting
Status: COMPLETED
Conditions: Labor; Forced or Induced, Affecting Fetus or Newborn|Labor Onset and Length Abnormalities
Interventions: OTHER: Cervical ripening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pembrolizumab (MK-3475) Plus Enzalutamide Plus Androgen Deprivation Therapy (ADT) Versus Placebo Plus Enzalutamide Plus ADT in Participants With Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) (MK-3475-991/KEYNOTE-991)-China Extension
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Hormone-Sensitive Prostate Cancer
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Enzalutamide|DRUG: Androgen Deprivation Therapy (ADT)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel and GM-CSF in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed By Surgery
Status: SUSPENDED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: sargramostim|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Intraocular Pressure Measurement With the Novel TonoVera Device With Other Commonly Used Devices
Status: RECRUITING
Conditions: Glaucoma
Interventions: DEVICE: Tono-Vera tonometer|DEVICE: Goldman Applanation Tonometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Robotic Surgery in the Seated Position for Benign and Malignant Lesions of the Head and Neck
Status: COMPLETED
Conditions: Oropharyngeal Neoplasms|Head and Neck Cancer
Interventions: DEVICE: Transoral Robotic Surgery (TORS) with the daVinci Robotic Surgical System device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of tDCS Combined With Therapeutic Exercises in Patients With Parkinson's Disease.
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DEVICE: tDCS|BEHAVIORAL: Exercise Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Addressing Cognitive Fog in Long-COVID-19 Patients
Status: TERMINATED
Conditions: Cognitive Impairment|Long COVID
Interventions: BEHAVIORAL: Digital cognitive behavioral intervention-RxWell|DRUG: Amphetamine-Dextroamphetamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Efficacy and Safety of CBD TPM Capsules for Use in Insomnia
Status: NOT_YET_RECRUITING
Conditions: Insomnia
Interventions: DRUG: Cannabidiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxytocin to Enhance Integrated Treatment for AUD and PTSD
Status: RECRUITING
Conditions: PTSD|Alcohol Use Disorder
Interventions: DRUG: 40 IU Intranasal Oxytocin|DRUG: Placebo|BEHAVIORAL: Concurrent Treatment of PTSD and Substance Use Disorders using Prolonged Exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Head Elevation During Pre-oxygenation Can Delay Desaturation Time
Status: COMPLETED
Conditions: Surgery|Desaturation of Blood|Apnea
Interventions: PROCEDURE: Supine position|PROCEDURE: 20 degree head elevation position|PROCEDURE: 30 degree head elevation position|PROCEDURE: 45 degree head elevation position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Use of Mesenchymal Stem Cells (MSCs) Differentiated Into Neural Stem Cells (NSCs) in People With Parkinson's (PD).
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: BIOLOGICAL: Injection of Umbilical cord derived MSCs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurocognitive Outcome Assesment in Patients With Peri-optic Meningiomas After Excision With Or Without Pealing Of The Outer Layer Of The Cavernous Sinus: A Randomized Controlled Single Blinded Trial.
Status: UNKNOWN
Conditions: Neurocognitive Outcome Assesment in Patients With Perioptic Meningiomas
Interventions: PROCEDURE: surgical excision of the tumor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Docetaxel and Cisplatin Combined With Nimotuzumab As First-Line Treatment in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Docetaxel and Cisplatin and Nimotuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Effect of a Strategy-Based Cognitive Intervention for Parkinson Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: MultiContext for PD Strategy Training|BEHAVIORAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intake-dependent Effect of Cocoa Flavanol Absorption, Metabolism and Excretion in Humans
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: 100 mg of Cocoa Flavanols/70 kg BW|OTHER: 200 mg of Cocoa Flavanols/70 kg BW|OTHER: 400 mg of Cocoa Flavanols/70 kg BW|OTHER: 1000 mg of Cocoa Flavanols/70 kg BW
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of a Three-dimensionally Corrective Exercise Therapy for Scoliosis
Status: UNKNOWN
Conditions: Idiopathic Scoliosis
Interventions: BEHAVIORAL: Three-dimensionally corrective exercise for scoliosis|BEHAVIORAL: Conventional exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Agent Lenalidomide in Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia
Status: TERMINATED
Conditions: Leukemia|Relapsed Adult Acute Lymphocytic Leukemia
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-world Evaluation of GLP-1 Receptor Agonists (GLP-1RA) on Efficacy and Persistence, Adherence and Therapeutic Inertia Among Type 2 Diabetes Adults With Obesity
Status: COMPLETED
Conditions: Type 2 Diabetes|Obesity
Interventions: DRUG: GLP-1RA|DRUG: SGLT2i|DRUG: Insulin|DRUG: Miscellany
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 3 Study of Aztreonam for Inhalation Solution (AZLI) in a Continuous Alternating Therapy Regimen for the Treatment of Chronic Pseudomonas Aeruginosa Infection in Patients With CF
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: AZLI|DRUG: Placebo to match AZLI|DRUG: Tobramycin inhalation solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Benefit of Intensified Peri-operative Chemotherapy Within High-risk CINSARC Patients With Resectable Soft-tissue Sarcomas
Status: RECRUITING
Conditions: Non-metastatic Soft-tissue Sarcoma|Resectable
Interventions: DRUG: Doxorubicin|DRUG: Ifosfamide or dacarbazine|DRUG: Doxorubicin|DRUG: Ifosfamide or dacarbazine|DRUG: At the discretion of the investigator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Suicide Risk Among Aging Caregivers of Persons With AD/ADRD
Status: NOT_YET_RECRUITING
Conditions: Suicide|Depression|Caregiver Burden|Physical Health|Inflammation
Interventions: BEHAVIORAL: Adapted Dialectical Behavior Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Encopresis in Children With Autism Spectrum Disorders
Status: COMPLETED
Conditions: Encopresis|Autism Spectrum Disorder
Interventions: BEHAVIORAL: MIE Treatment|DRUG: Glycerin Suppository|COMBINATION_PRODUCT: Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human Study of Hydroxytyrosol on Phase II Enzymes in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: hydroxytyrosol|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of SPD489 on Executive Function Behaviors in Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: ADHD Specifically With Executive Function Impairment
Interventions: DRUG: SPD489|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of BL-B01D1+PD-1 Monoclonal Antibody in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma and Other Solid Tumors
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: BL-B01D1|DRUG: PD-1 monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ST Monitoring to Detect Acute Coronary Syndrome Events in Implantable Cardioverter Defibrillator Patients
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Fortify® ST, Fortify Assura® ST, Ellipse® ST family of devices
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: 1 Week Versus 6 Weeks of Levetiracetam in Surgical Brain Tumor Patients
Status: COMPLETED
Conditions: Brain Neoplasms|Brain Cancer|Brain Tumors|Cancer of the Brain|Cancer of Brain|Seizure
Interventions: DRUG: Levetiracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prognostic Value of Measuring DsAz by MRI in Cirrhotic Patients on Prophylactic Treatment With β Blocker (AzyMR)
Status: COMPLETED
Conditions: Bleeding Esophageal Varices|Cirrhosis
Interventions: OTHER: azygos blood flow measurements by MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Whey Protein on Posprandial Glucose, Insulin GLP-1, GIP and DPP4 in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Whey before Breakfast|DIETARY_SUPPLEMENT: Water before breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: INCB050465 in Combination With Rituximab, Bendamustine and Rituximab, or Ibrutinib in Participants With Previously Treated B-Cell Lymphoma (CITADEL-112)
Status: COMPLETED
Conditions: B-cell Lymphoma
Interventions: DRUG: Parsaclisib|DRUG: Rituximab|DRUG: Bendamustine|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective, Multicenter, RCT of the Tenex Ultrasound System
Status: NOT_YET_RECRUITING
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: Tenex TXB MicroTip Ultrasound system plus SOC|OTHER: Standard of Care for diabetic foot ulcer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bronchoscopic Sampling Techniques in Sarcoidosis
Status: UNKNOWN
Conditions: Mediastinal Lymph Node Enlargement|Sarcoidosis|Tuberculosis|Lymphomas
Interventions: PROCEDURE: EBUS guided transbronchial forceps biopsy (EBUS-TBFB)|PROCEDURE: EBUS guided transbronchial needle aspiration (EBUS-TBNA)|PROCEDURE: large bore (19G) histologic needle biopsy of the mediastinal lymph nodes|PROCEDURE: Bronchoalveolar lavage (BAL)|PROCEDURE: Endobronchial forceps biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase I Study to Evaluate the Taste of Belumosudil Oral Suspensions & Assess Relative Bioavailability
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Part 1: Belumosudil 40 mg/mL Sequence ABFCED|DRUG: Part 1: Belumosudil 40 mg/mL Sequence BCADFE|DRUG: Part 1: Belumosudil 40 mg/mL Sequence CDBEAF|DRUG: Part 1: Belumosudil 40 mg/mL Sequence DECFBA|DRUG: Part 1: Belumosudil 40 mg/mL Sequence EFDACB|DRUG: Part 1: Belumosudil 40 mg/mL Sequence FAEBDC|DRUG: Part 2: Belumosudil 200 mg Sequence GHI|DRUG: Part 2: Belumosudil 200 mg Sequence HIG|DRUG: Part 2: Belumosudil 200 mg Sequence IGH|DRUG: Part 2: Belumosudil 200 mg Sequence IHG|DRUG: Part 2: Belumosudil 200 mg Sequence GIH|DRUG: Part 2: Belumosudil 200 mg Sequence HGI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Healthy Term Infants Fed Milk-Based Formulas
Status: TERMINATED
Conditions: Infants
Interventions: OTHER: Standard Milk-based Formula Containing Carotenoid|OTHER: Investigational Milk-based Formula Containing Carotenoid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Administration of L. Paracasei 28.4 as an Adjunct to the Treatment of Periodontitis
Status: RECRUITING
Conditions: Periodontitis
Interventions: OTHER: FMUD+Probiotic|OTHER: FMUD+Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of BIBR 1048 MS Tablets in Healthy Subjects With or Without Food
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIBR 1048 MS tablet|DRUG: BIBR 1048 MS solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adults With Moderate to Severe Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Budesonide|DRUG: Budesonide|DRUG: Budesonide|DRUG: Budesonide|DRUG: Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Fasting for Metabolic Health, Does Meal Timing Matter?
Status: COMPLETED
Conditions: Type 2 Diabetes|Insulin Resistance
Interventions: BEHAVIORAL: Lifestyle intervention B|BEHAVIORAL: Lifestyle Intervention D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Performance Comparison of 2 THERANOVA 400 Dialyzer Prototypes in HD With High-Flux Dialyzers in HD and hv HDF Mode
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DEVICE: THERANOVA 400 dialyzer prototype AA|DEVICE: THERANOVA 400 dialyzer prototype BB|DEVICE: FX CorDiax 80 Dialyzer|DEVICE: FX CorDiax 800 Dialyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Complications According to Ultrasound-guided Central Venous Catheters Insertion Site: a Non-inferiority Randomized Clinical Trial
Status: UNKNOWN
Conditions: Catheterization, Central Venous|Ultrasonography
Interventions: PROCEDURE: Central venous catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: First in Human Study of AZD9592 in Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumours|Carcinoma Non-small Cell Lung|Head and Neck Neoplasms|Colorectal Neoplasms
Interventions: DRUG: AZD9592|DRUG: Osimertinib|DRUG: 5-Fluorouracil (5-FU)|DRUG: Leucovorin|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of rAAV2-ND4 Treatment of Leber Hereditary Optic Neuropathy (LHON)
Status: COMPLETED
Conditions: Leber Hereditary Optic Neuropathy
Interventions: DRUG: rAAV2-ND4
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Atazanavir Treatment on Type 2 Diabetes Mellitus Related Endothelial Dysfunction
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus Related Endothelial Dysfunction
Interventions: DRUG: placebo + atazanavir|DRUG: atazanavir + placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Left Atrial Remodelling in Hypertension: Effects of Ramipril or Irbesartan
Status: UNKNOWN
Conditions: Left Atrial Volume|Hypertensive Heart Disease|Antihypertensive Drugs|Diastolic Function|Renin Angiotensin System
Interventions: DRUG: ramipril|DRUG: irbesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Follow up of Mucosal Tissue Height Influence on Peri-implant Bone Levels.
Status: COMPLETED
Conditions: Edentulous Alveolar Ridge
Interventions: PROCEDURE: Thin Tissues|PROCEDURE: Thick Tissues|PROCEDURE: Surgically augmented thin tissues
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Longitudinal Study on the Evolution Trend and Influencing Factors of Postoperative Reflux of Esophageal Cancer Based on PEPTEST Technique
Status: ENROLLING_BY_INVITATION
Conditions: GASTROINTESTINAL NEOPLASMS
Interventions: DIAGNOSTIC_TEST: PEPTEST test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: FOCUS-CI: A Preventive Intervention With Children and Families of the Combat Injured
Status: TERMINATED
Conditions: Stress Disorders|Combat Disorders|Traumatic Stress Disorders
Interventions: BEHAVIORAL: Standard of Care|BEHAVIORAL: FOCUS-CI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Heated Humidified Breathing Circuit Rewarming in Hypothermic Post Cardiopulmonary Bypass Patients.
Status: COMPLETED
Conditions: Hypothermia|Rewarming
Interventions: DEVICE: Heated Humidified Breathing Circuit and Forced Air Blanket
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antineoplaston Therapy in Treating Patients With Cancer of the Small Intestine
Status: TERMINATED
Conditions: Small Intestine Cancer
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety and Efficacy of Etanercept in Patients With Psoriatic Arthritis Treated by Rheumatologists
Status: COMPLETED
Conditions: Arthritis, Psoriatic|Psoriasis|Skin Diseases, Papulosquamous
Interventions: DRUG: Etanercept
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison Between Dexmeditomidine, Midazolam and Ketamine as a Sedative to Help Cannula Insertion in Pediatric Patient
Status: COMPLETED
Conditions: Cannula Site Pain
Interventions: DRUG: Ketamine|DRUG: Midazolam|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pragmatic Evaluation of Respiratory Distress Syndrome Treatment in Africa
Status: NOT_YET_RECRUITING
Conditions: Respiratory Distress Syndrome in Premature Infant|RDS of Prematurity|Surfactant Deficiency Syndrome Neonatal|Premature Birth
Interventions: DRUG: Surfactant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "REACT-FM-EXT": Real-World Evidence From Smartphone-Based Acceptance and Commitment Therapy in Fibromyalgia: An Extension Study
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: Digital ACT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pomalidomide in Relapsed and Refractory Multiple Myeloma (RRMM)
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Pomalidomide|DRUG: Dexamethasone|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3478006 in Healthy Participants
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: LY3478006 - IV|DRUG: LY3478006 - SC|DRUG: Placebo - IV|DRUG: Placebo - SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Two Drugs Regimen in Treatment of Complicated Typhoid Fever in Children
Status: COMPLETED
Conditions: Typhoid Fever
Interventions: DRUG: Meropenem Injection|DRUG: Azithromycin Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Effect of Intravenous Morphine vs Intravenous Ibuprofen and Acetaminophen vs Intravenous Ibuprofen
Status: COMPLETED
Conditions: Multiple Trauma|Acute Pain Due to Trauma
Interventions: DRUG: Ibuprofen 800 mg|DRUG: Morphine Sulfate|DRUG: Ibuprofen 400 mg plus Acetaminophen 1000 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy With or Without Radiation, Low and Intermediate Risk Hodgkins Lymphoma, TXCH-HD-12A
Status: COMPLETED
Conditions: Hodgkin Disease
Interventions: DRUG: ABVE-PC|DRUG: DECA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Central Executive Training and Parent Training for ADHD
Status: RECRUITING
Conditions: ADHD
Interventions: DEVICE: Central Executive Training (CET)|BEHAVIORAL: Behavioral Parent Training (BPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated or Viral Neoantigens in a Patient With Metastatic Cancer Plus the Administration of Pembrolizumab
Status: WITHDRAWN
Conditions: Metastatic HPV-16 Positive Squamous Cell Anal Cancer
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Aldesleukin|DRUG: Pembrolizumab (KEYTRUDA(R))|BIOLOGICAL: Individual Patient TCR-Transduced PBL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Docetaxel + Estramustine + Hydrocortisone Versus Docetaxel + Prednisone in Patients With Advanced Prostate Cancer
Status: TERMINATED
Conditions: Prostatic Neoplasms
Interventions: DRUG: Docetaxel + Estramustine + Hydrocortisone|DRUG: Docetaxel + Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation and Modeling of the G-CSF Effect on the Evolution of Neutrophils During Chemotherapy Based on Eribulin
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: ERIBULIN + G-CSF (Granulocyte-Colony Stimulating Factor)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: App for Pregnancy Smoking Cessation With Peer Support
Status: RECRUITING
Conditions: Smoking Cessation|Tobacco Smoking
Interventions: BEHAVIORAL: SFT 2.0|BEHAVIORAL: Active control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Deep Neuromuscular Blockade on Respiratory Mechanics
Status: COMPLETED
Conditions: Neuromuscular Blockade
Interventions: OTHER: Moderate NMB|OTHER: Deep NMB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Post-mastectomy Recovery: Comparing Preoperative PECS-II Blocks With Intraoperative Pectoral Blocks
Status: NOT_YET_RECRUITING
Conditions: Mastectomy; Lymphedema|Breast Cancer
Interventions: DRUG: Bupivacain|DRUG: Exparel|PROCEDURE: Intraoperative Pecs II block (IOB) & superior AT (EX or BP)|PROCEDURE: Preoperative Pecs II block (POB) & superior AT (EX or BP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tracheostomy in ICU With a Double Lumen Endotracheal Tube
Status: UNKNOWN
Conditions: Acute Respiratory Failure|Heart Failure|Neurological Disease
Interventions: DEVICE: Double lumen endotracheal tube tracheostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Evaluate the Efficacy of Selenium for the Prevention of Chemotherapy-induced Mucositis During Autologous Stem Cell Transplantation.
Status: UNKNOWN
Conditions: Mucositis Oral|Stem Cell Transplant Complications
Interventions: DRUG: Selenium|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Perforated Barrier Membranes Maintain Physiologic Gingival Crevicular Fluid Growth Factor Levels
Status: COMPLETED
Conditions: Vascular Endothelial Growth Factor Overexpression|Membrane Alteration
Interventions: DEVICE: collagen membrane|DEVICE: collagen membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluated the Effectiveness of Milnacipran to Reduce Pain Levels in Individuals With Chronic Migraine
Status: COMPLETED
Conditions: Chronic Migraine
Interventions: DRUG: Milnacipran|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective Multicenter Cohort Study About Internal Fixation Using PFUN Versus PFNA for Femoral Intertrochanteric Fracture
Status: RECRUITING
Conditions: Femoral Intertrochanteric Fractures
Interventions: DEVICE: PFUN|DEVICE: PFNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Prucalopride for the Treatment of Elderly Patients With Chronic Constipation
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: prucalopride|DRUG: Prucalopride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Timing of rhPSMA-7.3 (18F) for Assessing Site(s) of Recurrent Disease Following Radical Prostatectomy
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: 18F-Labeled Positron Emission Tomography (PET) Diagnostic Agent|DEVICE: PET MRI Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Calcitriol and Dexamethasone in Treating Patients With Prostate Cancer Who Have Undergone Surgery or Radiation Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: calcitriol|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of IV Acetaminophen Versus Oral Acetaminophen
Status: RECRUITING
Conditions: Nephrectomy
Interventions: DRUG: acetaminophen|DRUG: Acetaminophen|DRUG: Placebos|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial: Effectiveness and Efficiency of Physical Exercise in Cancer Patients
Status: UNKNOWN
Conditions: Non-Small-Cell Lung Carcinoma|Digestive System Neoplasms|Breast Neoplasms
Interventions: OTHER: Supervised Physical activity|BEHAVIORAL: education program on healthy habits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Ranibizumab Plus Transpupillary Thermotherapy for Neovascular Age-Related Macular Degeneration (AMD) Study
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: BIOLOGICAL: ranibizumab|PROCEDURE: TTT|PROCEDURE: Sham TTT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transvaginal Botulinum Toxin A Chemodenervation for Overactive Bladder
Status: COMPLETED
Conditions: Overactive Bladder|Bladder, Overactive|Urge Incontinence|Urgency Urinary|Urinary Frequency/Urgency
Interventions: DRUG: Transvaginal botulinum toxin A (BTA) injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Effectiveness of PEA Compared to Placebo for Reducing Pain Severity and Duration of Migraines.
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Palmitoylethanolamide sold as Levagen +|DRUG: Placebo comparator - maltodextrin and microcrystalline cellulose mix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mepolizumab for the Treatment of Chronic Cough With Eosinophilic Airways Diseases
Status: RECRUITING
Conditions: Chronic Cough|Eosinophilic Bronchitis|Asthma
Interventions: DRUG: Mepolizumab|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-Ambulatory SCI Walk Using a Robotic Exoskeleton: Effect on Bone and Muscle
Status: UNKNOWN
Conditions: Spinal Cord Injury
Interventions: DEVICE: Exoskeleton Training|OTHER: Muscle Biopsies|OTHER: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Maltodextrin's Effect on Cardiac Function in Cardiac Surgery
Status: NOT_YET_RECRUITING
Conditions: Left Ventricular Dysfunction|Quality of Recovery|Right Ventricular Dysfunction
Interventions: DRUG: Maltodextrin solution|DRUG: Placebo solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Diet on the Gut-Muscle Axis in Older Adults
Status: RECRUITING
Conditions: Sarcopenia|Dietary Exposure|Microbial Colonization
Interventions: OTHER: Low-soluble fiber diet|OTHER: High-soluble fiber diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy of Percutaneous Implantation of Autologous Myoblasts in Patients With Old Infarction
Status: TERMINATED
Conditions: Old Myocardial Infarction
Interventions: PROCEDURE: Percutaneous autologous myoblast implantation|PROCEDURE: Cardiac revascularization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Different Treatment Methods in Lumbal Disc Herniation Treatment
Status: COMPLETED
Conditions: Lumbar Disc Herniation
Interventions: OTHER: non -surgical spinal decompression therapy|OTHER: deep friction massage,|OTHER: electrotherapy|OTHER: exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture in the Management of Post Operative Symptoms in Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: Acupuncture|PROCEDURE: Sham Acupuncture|OTHER: Patient to receive standard care without Acupuncture or Sham Acupuncture.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Of Vinblastine in Combination With Nilotinib in Children, Adolescents and Young Adults
Status: COMPLETED
Conditions: Refractory Low-grade Gliomas|Recurrent Low-grade Gliomas
Interventions: DRUG: Nilotinib|DRUG: Vinblastine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ALTAIR - Alternative Antiretroviral Strategies : a Comparison of Three Initial Regimens
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV)
Interventions: DRUG: Truvada (fixed dose combination of tenofovir + emtricitabine) + Stocrin (efavirenz)|DRUG: Truvada (fixed dose combination of tenofovir + emtricitabine)+ ritonavir/atazanavir (r/ATV)|DRUG: Truvada (fixed dose combination of tenofovir + emtricitabine) + zidovudine (ZDV) + abacavir (ABC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Huperzine A on Presbycusis(Δ,kHz, dB,MMSE, AD)
Status: UNKNOWN
Conditions: Presbycusis|Tinnitus|Cognitive Impairment
Interventions: DRUG: BTHE and Huperzine A|OTHER: BETH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of TAK-559 in Treating Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: TAK-559|DRUG: TAK-559|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Biomarker-Guided CNI Substitution In Kidney Transplantation
Status: RECRUITING
Conditions: Kidney Transplant
Interventions: BIOLOGICAL: Abatacept|PROCEDURE: Standard of Care at US Transplant Centers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Denileukin Diftitox Followed by Vaccine Therapy in Treating Patients With Metastatic Cancer
Status: COMPLETED
Conditions: Breast Cancer|Colorectal Cancer|Lung Cancer|Pancreatic Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: denileukin diftitox|BIOLOGICAL: recombinant fowlpox-CEA(6D)/TRICOM vaccine|BIOLOGICAL: therapeutic autologous dendritic cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: INNA-051 Influenza Challenge Study
Status: COMPLETED
Conditions: Influenza Prophylaxis
Interventions: DRUG: INNA-051|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Upadacitinib in Adolescents and Adults With Moderate to Severe Atopic Dermatitis (Measure Up 2)
Status: ACTIVE_NOT_RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: Placebo for Upadacitinib|DRUG: Upadacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Study of Safety and Efficacy of Roflumilast in Japanese Patients With Bronchial Asthma (20 to 71 y) (APTA-2217-07)
Status: COMPLETED
Conditions: Bronchial Asthma
Interventions: DRUG: Roflumilast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Therapy With BRAINMAX® Using fMRI for the Treatment of Patients With Asthenia After COVID-19
Status: COMPLETED
Conditions: Asthenia|COVID-19|Functional MRI|Cognitive Impairment
Interventions: OTHER: Structural and functional MRI|DRUG: Ethyl methyl hydroxypyridine succinate + Meldonium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Double Ovarian Stimulation as Accumulation Strategy for Older Infertile Patients With Suboptimal Ovarian Response
Status: UNKNOWN
Conditions: Infertility, Female|Ovarian Stimulation|In Vitro Fertilisation
Interventions: DRUG: Pergoveris|DRUG: Clomiphene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Does of Acupuncture on Premenstrual Syndrome Efficacy Analysis
Status: UNKNOWN
Conditions: Premenstrual Syndrome
Interventions: DRUG: NSAIDs or oral contraceptives treatment|DEVICE: Low dose acupuncture|DEVICE: High dose acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial of Prednisolone, Itraconazole, or Their Combination in Allergic Bronchopulmonary Aspergillosis
Status: RECRUITING
Conditions: Allergic Bronchopulmonary Aspergillosis
Interventions: DRUG: Prednisolone|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketogenic Diet for Psychotic Disorders
Status: RECRUITING
Conditions: Psychosis; Acute|Psychosis|Psychotic Disorders|Schizophrenia
Interventions: OTHER: Ketogenic diet intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Neonatal Abstinence Syndrome
Status: COMPLETED
Conditions: Neonatal Abstinence Syndrome
Interventions: DRUG: Methadone|DRUG: Diluted Deodorized Tincture of Opium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of KI1001 in the Treatment of ≥ 55 Years Old Insomnia Patients
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders
Interventions: DRUG: KI1001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Transcranial Direct Current Stimulation on the Voice
Status: COMPLETED
Conditions: Voice and Resonance Disorders|Transcranial Direct Current Stimulation|Voice Disturbance
Interventions: DEVICE: Transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Allopurinol or Febuxostat to Prevent Contrast Induced Acute Kidney Injury (CI-AKI)
Status: UNKNOWN
Conditions: Contrast-induced Nephropathy|Contrast-induced Acute Kidney Injury
Interventions: DRUG: Allopurinol|DRUG: Febuxostat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of a Single Dose of Cranberry Beverage on Inflammation and Oxidative Stress
Status: COMPLETED
Conditions: Inflammation
Interventions: OTHER: Low Calorie Cranberry Juice Cocktail|OTHER: Cranberry Extract Beverage|OTHER: Non-Cranberry Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Sirolimus in Patients With Dilated Cardiomyopathy Infected With Kaposi Sarcoma-associated Virus
Status: RECRUITING
Conditions: Dilated Cardiomyopathy|Kaposi's Sarcoma-Associated Herpesvirus Infection
Interventions: DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extra Corporeal Shock Wave Versus Phonophoresis in Sub Acromial Impingement Syndrome.
Status: COMPLETED
Conditions: Sub Acromial Impingement Syndrome
Interventions: DEVICE: Shockwave therapy|DEVICE: Phonophoresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of GSK Biologicals Tuberculosis Vaccines (692342) to Healthy Adults
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: GSK Biologicals' AS01B adjuvant|BIOLOGICAL: GSK Biologicals' Candidate Tuberculosis Vaccine (692342) - Formulation 1|BIOLOGICAL: GSK Biologicals' Candidate Tuberculosis Vaccine (692342) - Formulation 2|BIOLOGICAL: GSK Biologicals' Candidate Tuberculosis Vaccine (692342) - Formulation 3|BIOLOGICAL: GSK Biologicals' Candidate Tuberculosis Vaccine (692342) - Formulation 4 - Dosage 1|BIOLOGICAL: GSK Biologicals' Candidate Tuberculosis Vaccine (692342) - Formulation 4 - Dosage 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease
Status: NOT_YET_RECRUITING
Conditions: Muscle-Invasive Bladder Carcinoma
Interventions: BIOLOGICAL: Synthetic long peptide personalized cancer vaccine|DRUG: Poly ICLC|BIOLOGICAL: Nivolumab|DEVICE: Signatera assay
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Drug Interaction Study Between AVP-786 and Paroxetine and Between AVP-786 and Duloxetine in Healthy Subjects
Status: COMPLETED
Conditions: Drug-drug Interaction
Interventions: DRUG: AVP-786|DRUG: Paroxetine|DRUG: Duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pilot of Zinc Acetate to Improve Chronic Cough
Status: COMPLETED
Conditions: Cough
Interventions: DRUG: Zinc Acetate 50 Mg Oral Capsule|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT