pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Tissue and Blood Samples From Patients With Recurrent Prostate Cancer Who Received Lapatinib on Clinical Trial ECOG-E5803
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: GENETIC: mutation analysis|GENETIC: polymorphism analysis|GENETIC: protein expression analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tauroursodeoxycholic Acid for Protease-inhibitor Associated Insulin Resistance
Status: COMPLETED
Conditions: HIV Related Insulin Resistance|Protease Inhibitor Related Insulin Resistance|Endoplasmic Reticulum Stress
Interventions: DRUG: Tauroursodeoxycholic acid|OTHER: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Early vs Postponed Parenteral Nutrition After Emergency Abdominal Surgery
Status: RECRUITING
Conditions: Laparotomy|Bowel Obstruction|Ischemia, Mesenteric
Interventions: DRUG: SmofKabiven
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dose Escalation Study to Evaluate the Safety/Tolerability and Efficacy of EA-2353 in Subjects With Retinitis Pigmentosa
Status: ACTIVE_NOT_RECRUITING
Conditions: Retinitis Pigmentosa|Retinitis Pigmentosa Syndrome
Interventions: DRUG: EA-2353
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Traditional Music Therapy on Burnout Syndrome Among Healthcare Workers: Psycho-Neuro-Immuno-Endocrine Aspects
Status: RECRUITING
Conditions: Burnout, Professional
Interventions: BEHAVIORAL: Traditional Music Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intradermal Influenza Vaccine With Topical Imiquimod in Elderly and Chronic Illness Patients
Status: UNKNOWN
Conditions: Influenza
Interventions: BIOLOGICAL: Vaxigrip tetra|BIOLOGICAL: Fluzone high-dose|DRUG: Aldara 5% Topical Cream|DRUG: Aqueous cream BP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Milk and Cheese on Fecal Fat Excretion and Blood Lipid
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: Dietary intervention (without dairy products)|OTHER: Dietary intervention (high milk content)|OTHER: Dietary intervention (high cheese content)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dietary Supplementation on Body Fat Composition
Status: RECRUITING
Conditions: Dyslipidemias|Pre-diabetes
Interventions: OTHER: Placebo treatment|DIETARY_SUPPLEMENT: Plant derived phenolics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Suanzaoren Decoction and Huanglian Wendan Decoction on Biorhythm of Insomnia Patients
Status: COMPLETED
Conditions: Chronic Insomnia|Melatonin|Circadian Rhythm|Suanzaoren Decoction and Huanglian Wendan
Interventions: DRUG: Suanzaoren Decoction and Huanglian Wenda Decoction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Find Out if Therapy With the Drug Pregabalin Relieves Pain During Shingles Compared With Placebo
Status: TERMINATED
Conditions: Herpes Zoster|Postherpetic Neuralgia
Interventions: DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: BMS-582664 in Combination With Erbitux in Patients With Advanced Gastrointestinal Malignancies
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Brivanib + Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TRuE AD2 - An Efficacy and Safety Study of Ruxolitinib Cream in Adolescents and Adults With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Ruxolitinib cream|DRUG: Vehicle cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Grazoprevir and Elbasvir for GT1ang GT6 With and Without HIV
Status: UNKNOWN
Conditions: Compensated Cirrhosis
Interventions: DRUG: Grazaoprevir/Elbasavir|DRUG: Grazaoprevir/Elbasavir/RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Safety of Total Percutaneous Closure of Femoral Arterial Access Sites in the Veno-arterial ECMO Patients
Status: UNKNOWN
Conditions: Cardiogenic Shock|Extracorporeal Membrane Oxygenation|Myocarditis|Hypertension, Pulmonary|Pulmonary Embolism|Heart Arrest|Medication Overdoses
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Polish Infants and Toddler Nutritional Study
Status: NOT_YET_RECRUITING
Conditions: Diet Habit|Dietary Habits|Diet, Healthy|Children|Child|Nutritional Deficiency|Nutritional Status|Macronutrients|Consumption|Dietary Assessment|Cross-sectional Study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Postoperative Results of Early Versus On-demand Maternal Feeding After Cesarean Delivery
Status: COMPLETED
Conditions: Cesarean Delivery|Feeding Patterns|Patient Satisfaction|Postoperative Nausea and Vomiting
Interventions: BEHAVIORAL: Early feeding|BEHAVIORAL: On- Demand feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Tolerance of an Ovarian Stimulation Protocol Combining Follicle Stimulating Hormone (FSH) and Degarelix Acetate in Female Candidates for Fertility Preservation Before Chemotherapy for Breast Cancer
Status: COMPLETED
Conditions: Invasive Ductal Breast Carcinoma
Interventions: DRUG: Degarelix injection(s)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Percutaneous Neuromodulation in the Treatment of Cervical Pain in University Students.
Status: NOT_YET_RECRUITING
Conditions: Neck Pain
Interventions: PROCEDURE: Ecoguided Percutaneous Neuromodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Adherence in Global Airways
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Rhinosinusitis Without Nasal Polyps|Asthma|Chronic Rhinosinusitis With Nasal Polyps|Chronic Rhinosinusitis (Diagnosis)
Interventions: BEHAVIORAL: Controlgroup|BEHAVIORAL: Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy, Safety and Tolerability of 3% LTX-109 for Nasal Decolonisation of Staphylococcus Aureus
Status: COMPLETED
Conditions: Nasal Decolonization of Staphylococcus Aureus
Interventions: DRUG: Vehicle gel, 4 + 4 applications or 4 + 2 applications|DRUG: LTX-109 3% gel, 4 + 4 applications|DRUG: LTX-109 3% gel, 4 + 2 applications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Myocardial Biomechanics and Early Short-term Doxycycline Therapy in Patients With Primary Anterior STEMI
Status: UNKNOWN
Conditions: Vascular Diseases|Cardiovascular Diseases|Acute Myocardial Infarction
Interventions: DRUG: Doxycycline|OTHER: Standard care for STEMI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Examination of the Use of Electrophysiological Brain Monitoring to Direct the Treatment of Mild Cognitive Impairment
Status: UNKNOWN
Conditions: Mild Cognitive Impairment
Interventions: DEVICE: EEG based feedback|BEHAVIORAL: Standard practice based feedback|BEHAVIORAL: No feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Effects of Delayed Clamping on Neonatal Bilirubin Levels Between Pregnant Women With Intrahepatic Cholestasis of Pregnancy and Normal Pregnant Women
Status: RECRUITING
Conditions: Intrahepatic Cholestasis of Pregnancy
Interventions: OTHER: clamp time of umbilical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study Of Candonilimab Combined With Radiotherapy In The Treatment of Locally Advanced Cervical Cancer
Status: RECRUITING
Conditions: Locally Advanced Cervical Cancer
Interventions: DRUG: Candonilimab（AK104）|RADIATION: EBRT|RADIATION: BT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injuries|Autonomic Dysreflexia
Interventions: DRUG: Glyceryl Trinitrate Only Product in Oromucosal Dose Form|OTHER: Placebo sublingual spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Micropulse Laser on Dry Eye Disease Due to Meibomian Gland Dysfunction
Status: UNKNOWN
Conditions: Dry Eye|Dry Eye Syndromes|Meibomian Gland Dysfunction
Interventions: PROCEDURE: laser light
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydrolyzed Collagen and Undenatured Collagen Type II in OA Knee
Status: NOT_YET_RECRUITING
Conditions: Osteo Arthritis Knee
Interventions: DIETARY_SUPPLEMENT: Collagen|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Pharmacokinetic and Mass Balance of Single Dose [14C] AZD5718 in Volunteers
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DRUG: [14C]AZD5718 Oral Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Forward Head Posture Correction Impact on Temporomandibular Dysfunction
Status: NOT_YET_RECRUITING
Conditions: Temporomandibular Disorder|Forward Head Posture
Interventions: DEVICE: Denneroll cervical traction orthodontic|OTHER: stretching and strengthening exercises|DEVICE: Vacuum-formed soft occlusal splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Endoscopic Biopsic Needles for Pancreatic Tumors
Status: COMPLETED
Conditions: Pancreatic Tumor|Puncture
Interventions: PROCEDURE: EUS-FNB with 20-gauge Procore® needle|PROCEDURE: EUS-FNB with 22-gauge Acquire® needle
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Retatrutide (LY3437943) on Renal Function in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes
Status: RECRUITING
Conditions: Overweight or Obesity|CKD|Type 2 Diabetes
Interventions: DRUG: Retatrutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pregabalin in the Treatment of Essential Tremor
Status: COMPLETED
Conditions: Essential Tremor
Interventions: DRUG: pregabalin (Lyrica)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: QL1203 In Combination With Chemotherapy for Metastatic Colorectal Cancer to Determine Efficacy and Safety
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: QL1203|DRUG: Placebo|DRUG: mFOLFOX6 regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study in Children With the Diagnosis of Congenital Diaphragmatic Hernia (CDH) and Oesophageal Atresia (EA)
Status: COMPLETED
Conditions: Diaphragmatic Hernia|Oesophageal Atresia
Interventions: OTHER: Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical and Electrographic Changes in Responsive Neurostimulation System (RNS) Patients With Acupuncture Treatment
Status: RECRUITING
Conditions: Epilepsy
Interventions: DEVICE: Acupuncture intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The INVADER™ Percutaneous Transluminal Coronary Angioplasty (PTCA) Post Market Clinical Follow-up (PMCF) Study
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Disease|Vascular Diseases
Interventions: DEVICE: INVADER™ PTCA Balloon Dilatation Catheter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Video Game Playing on Lunch-time Food Intake in Children
Status: COMPLETED
Conditions: Exogenous Obesity
Interventions: DIETARY_SUPPLEMENT: Glucose Beverage|BEHAVIORAL: Video Game Playing|DIETARY_SUPPLEMENT: Control Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Palbociclib + Ganitumab In Ewing Sarcoma
Status: TERMINATED
Conditions: Ewing Sarcoma|Ewing's Sarcoma Recurrent
Interventions: DRUG: Palbociclib|DRUG: Ganitumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Focused Radiation Versus Systemic Therapy for Kidney Cancer Patients With Limited Metastasis, SOAR Study
Status: RECRUITING
Conditions: Metastatic Renal Cell Carcinoma|Stage IV Renal Cell Cancer AJCC v8
Interventions: PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|OTHER: Questionnaire Administration|PROCEDURE: Stereotactic Ablative Radiotherapy|PROCEDURE: Systemic Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Negative Symptoms of Psychosis In Real-world Environments
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: CBSST-CCT|BEHAVIORAL: Goal focused supportive contact
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Aliskiren 300mg Compared to Irbesartan 300mg and Ramipril 10 mg in the Setting of a Missed Dose for Patients With Essential Hypertension.
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Aliskiren
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Three Plasmodium Falciparum Isolates in a Controlled Human Malaria Infection
Status: COMPLETED
Conditions: Malaria
Interventions: OTHER: NF54|OTHER: NF135|OTHER: NF166
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: MENDS Study: Trial in Ventilated ICU Patients Comparing an Alpha2 Agonist Versus a Gamma Aminobutyric Acid (GABA)-Agonist to Determine Delirium Rates, Efficacy of Sedation, Analgesia and Discharge Cognitive Status
Status: COMPLETED
Conditions: Delirium
Interventions: DRUG: Dexmedetomidine|DRUG: Lorazepam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: GB491 Combined With Fulvestrant for HR+ HER2- Locally Advanced or Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Locally Advanced or Metastatic Breast Cancer
Interventions: DRUG: GB491+ Fulvestrant|DRUG: Placebo+Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Study to Evaluate the Effect of ISIS 681257 on Clopidogrel
Status: COMPLETED
Conditions: Elevated Lipoprotein(a)|Cardiovascular Diseases
Interventions: DRUG: ISIS 681257|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Therapy for Improving Symptoms in Patients With Acute Exacerbations of COPD by Hydrogen-Oxygen Generator With Neburlizer.
Status: COMPLETED
Conditions: Copd Exacerbation Acute
Interventions: DEVICE: oxyhydrogen|DEVICE: Oxygen|DRUG: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Reinforcement Schedules to Increase Fruit&Vegetable Intake, Reduce Waste, and Increase School Lunch Participation
Status: COMPLETED
Conditions: Behavioral Changes|Psychology, Social|Nutrition
Interventions: BEHAVIORAL: Variable (random) interval|BEHAVIORAL: Variable (non-random) interval|BEHAVIORAL: Variable (random) interval with table tents|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of Ketamine Infusions to Treat Clinically-depressed ICU Patients
Status: NOT_YET_RECRUITING
Conditions: Depression
Interventions: DRUG: Ketamine Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Ramelteon Tablets for Sublingual Administration (TAK-375SL) in the Maintenance Treatment of Bipolar 1 Disorder
Status: WITHDRAWN
Conditions: Bipolar Disorder
Interventions: DRUG: Ramelteon SL (Dose 1)|DRUG: Ramelteon SL (Dose 2)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study to Evaluate Conventional Radiation Therapy Followed by Radiosurgical Boost in Clinically Localized Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: Radiotherapy with IMRT and CyberKnife Boost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Interruption of the Coracohumeral Ligament for the Treatment of Frozen Shoulder
Status: COMPLETED
Conditions: Adhesive Capsulitis
Interventions: DEVICE: Tenex|DRUG: Local anesthetic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Infigratinib in Children and Adolescents With Achondroplasia
Status: ENROLLING_BY_INVITATION
Conditions: Achondroplasia
Interventions: DRUG: Infigratinib 0.25 mg/kg/day|DRUG: Placebo Comparator 0.25 mg/kg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Follow-up of Subjects Treated With OTL-300 for Transfusion Dependent Beta-thalassemia Study (TIGET-BTHAL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Beta Thalassaemia
Interventions: OTHER: Safety and Efficacy assessments
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Liraglutide on Blood Glucose Control in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: insulin glargine|DRUG: metformin|DRUG: glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Positive End-Expiratory Pressure on Functional Residual Capacity During Mechanical Ventilation
Status: UNKNOWN
Conditions: Mechanical Ventilation|Acute Respiratory Distress Syndrome|Functional Residual Capacity
Interventions: PROCEDURE: PEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Clinical Study of Adjuvant Chemotherapy on Intestinal and Urethral Flora in Patients With Gastric and Colon Cancer
Status: UNKNOWN
Conditions: Gastric Cancer|Colon Cancer
Interventions: DRUG: adjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cognitive-Behavioral Therapy for Irritability in Adolescents With High Functioning Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autism|Autism Spectrum Disorder (ASD|Asperger's Disorder|Pervasive Developmental Disorder (PDD-NOS)
Interventions: BEHAVIORAL: Cognitive-Behavioral Therapy (CBT) for Irritability
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nurse-led Alcohol Brief Intervention Plus Mobile Personalized Chat-based Support on Reducing Alcohol Use in University Students
Status: UNKNOWN
Conditions: Alcohol Misuse
Interventions: BEHAVIORAL: Alcohol brief intervention|BEHAVIORAL: 12-page health warning leaflet|BEHAVIORAL: Regular messages through Instant Messaging (IM)|BEHAVIORAL: Real-time chat-based support through IM Apps|BEHAVIORAL: General health through SMS|BEHAVIORAL: AUDIT score interpretation sheet adapted from the Department of Health of Hong Kong
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mobile Contingency Management for Marijuana and Tobacco Cessation
Status: COMPLETED
Conditions: Cigarette Smoking|Marijuana Abuse
Interventions: DRUG: bupropion|DRUG: transdermal nicotine patch|DRUG: Nicotine polacrilex|DRUG: nicotine lozenge|BEHAVIORAL: counseling for marijuana and smoking cessation|BEHAVIORAL: mobile contingency management
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of QVA149 on Health Related Quality of Life in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: QVA149|DRUG: Placebo to tiotropium|DRUG: Placebo to formoterol|DRUG: Tiotropium|DRUG: Formoterol|DRUG: Placebo to QVA149
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of ELGN-2112 on Intestinal Malabsorption in Preterm Infants
Status: NOT_YET_RECRUITING
Conditions: Intestinal Malabsorption
Interventions: DRUG: ELGN-2112|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ZK-Epo Given With Prednisone in Patients With Metastatic Androgen-independent Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Sagopilone (ZK 219477) + prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccines Against Salmonella Typhi
Status: COMPLETED
Conditions: Typhoid Fever|Enteric Fever
Interventions: BIOLOGICAL: Vi-TCV|BIOLOGICAL: Vi-PS Vaccine|BIOLOGICAL: Control (Men ACWY)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effects of Tomato Consumption on Steatosis, Intestinal Function and Glucose and Lipid Metabolism in Subjects With NAFLD
Status: RECRUITING
Conditions: NAFLD|IBS
Interventions: DIETARY_SUPPLEMENT: Experimental: Case Group - Tomato-free diet|DIETARY_SUPPLEMENT: Experimental: Case group - Diet enriched with tomatoes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antiviral Therapy for Patients With Chronic Hepatitis B Infection
Status: RECRUITING
Conditions: Chronic Hepatitis B Virus Infection
Interventions: DRUG: Entecavir|DRUG: Entecavir combined with Tenofovir Amibufenamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Brentuximab Vedotin Combined With AVD Chemotherapy in Patients With Newly Diagnosed Early Stage, Unfavorable Risk Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Hodgkin Lymphoma
Interventions: DRUG: Brentuximab vedotin (SGN-35)|DRUG: Doxorubicin HCL|DRUG: Vinblastine Sulfate|DRUG: Dacarbazine|RADIATION: Involved-Site Radiation Therapy (ISRT)|PROCEDURE: Interim PET|RADIATION: consolidation volume RT (CVRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GLP-1 Receptor Agonist Therapy and Albuminuria in Patients With Type 2 Diabetes
Status: TERMINATED
Conditions: Type2 Diabetes|Kidney Diseases
Interventions: DRUG: Exenatide Extended Release for Inj Susp 2 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Memantine for Prevention of Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: Memantine Hydrochloride Tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Therapy to Treat Ewing's Sarcoma, Rhabdomyosarcoma or Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma|Sarcoma|Rhabdomyosarcoma-Embryonal|Rhabdomyosarcoma- Alveolar|Neuroectodermal Tumors, Primitive, Peripheral
Interventions: DRUG: Tumor Purged/CD25 Depleted Lymphocytes|BIOLOGICAL: Tumor Purged/CD25 Depleted Lymphocytes with Tumor Lysate/KLH Pulsed Dendritic Cell Vaccine|DRUG: rhIL-7|BIOLOGICAL: Tumor Lysate/KLH Pulsed Dendritic Cell Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Eight-week Study of Saredutant and Paroxetine as Combination Treatment for Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: saredutant (SR48968)|DRUG: paroxetine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relation of Metabolic Rate of Omeprazole and Eradication of Helicobacter Pylori Infection
Status: COMPLETED
Conditions: Duodenal Ulcer|Helicobacter Pylori Infection
Interventions: DRUG: omeprazole plus amoxicillin|DRUG: omeprazole plus amoxicillin|DRUG: omeprazole plus amoxicillin|DRUG: omeprazole plus amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: In Vivo Comparison of Knee Kinematics for Subjects Implanted With Either a ConforMIS or Traditional Knee Implant
Status: COMPLETED
Conditions: Complications; Arthroplasty
Interventions: DEVICE: Conformis CR Total Knee Replacement|DEVICE: Off the Shelf
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sleep Optimization to Improve Glycemic Control in Adults With Type 1 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 1 Diabetes
Interventions: BEHAVIORAL: Sleep-Opt|BEHAVIORAL: Healthy Living
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CardiAQ-Edwards™ Transcatheter Mitral Valve Replacement (TMVR) Study
Status: WITHDRAWN
Conditions: Mitral Valve Regurgitation
Interventions: DEVICE: Transcatheter Mitral Valve Re-placement (TMVR) with the CardiAQ-Edwards™ Transcatheter Mitral Valve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Therapeutic Exercise on Cartilage Morphology and Physical Function for Individuals at High Risk of Knee Osteoarthritis
Status: RECRUITING
Conditions: Meniscus Tear
Interventions: OTHER: Progressive Resistance Exercise (PRE)|OTHER: Aerobic Exercise|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Direct and Indirect Benefits of Influenza Vaccine Versus Placebo in Healthy Children
Status: COMPLETED
Conditions: Influenza Virus Infection
Interventions: BIOLOGICAL: Inactivated influenza vaccine|BIOLOGICAL: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study of Glaukos® Trabecular Micro-Bypass System Model iS3 Infinite Vs. Competitor
Status: ACTIVE_NOT_RECRUITING
Conditions: Glaucoma|Glaucoma, Open-Angle
Interventions: DEVICE: iStent Infinite|DEVICE: Competitor Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of Growth Factors in Patients Undergoing Lucentis or Avastin Injections for Diabetic Macular Edema and Exudative Macular Degeneration
Status: COMPLETED
Conditions: Exudative Macular Degeneration|Diabetic Macular Edema
Interventions: DRUG: Avastin|DRUG: Avastin|DRUG: Lucentis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Outcome Study of Restrictive vs. Liberal Intraoperative Fluid Management Guided by PPV in Esophagectomy
Status: TERMINATED
Conditions: Other Complications of Esophagostomy
Interventions: OTHER: Intraoperative fluid therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Pembrolizumab in Lymphopenic Metastatic Breast Cancer Patients Treated With Metronomic Cyclophosphamide
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Cyclophosphamide 50mg|DRUG: Pembrolizumab 100 MG in 4 ML Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relating Abdominal Complications With Peritoneal Pressure Estimation and Reporting
Status: NOT_YET_RECRUITING
Conditions: Peritoneal Dialysis|Kidney Failure, Chronic|Hernia, Abdominal
Interventions: DIAGNOSTIC_TEST: Estimated intraperitoneal pressure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Multiple Dose Crossover Pharmacokinetics Study to Evaluate the Effects of Food on the Absorption of Oral Ganciclovir
Status: COMPLETED
Conditions: Cytomegalovirus Infections|HIV Infections
Interventions: DRUG: Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Comparison of Cervical Spine Movement During Tracheal Intubation Using the Pentax or the Glidescope
Status: UNKNOWN
Conditions: C-spine Movement During Intubation
Interventions: DEVICE: The glidescope video laryngoscopy|DEVICE: The Pentax airwayscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of a Supplement Enriched in Hydroxymethylbutyrate and Vitamin D on Muscle Strength in Hip Fracture
Status: TERMINATED
Conditions: Hip Fractures
Interventions: DIETARY_SUPPLEMENT: Supplement with HMB and vitamin D|DIETARY_SUPPLEMENT: Standard nutritional supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dietary Impacts on Oral Health in Autistic Children: A Cross-Sectional Analysis
Status: NOT_YET_RECRUITING
Conditions: Dental Caries in Children|Autistic Disorder|Dietary Habits
Interventions: OTHER: dietary preferences and their implications for oral health in children with Autism Spectrum Disorder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: K-ORCA: Testing a Decision Support Tool and Group Process for Selecting Interventions
Status: NOT_YET_RECRUITING
Conditions: Child Abuse|Decision Making|Child Welfare|Decision Making, Shared|Decision Support Technique|Social Facilitation|Implementation Science|Policy|Organizations|Consensus|Mental Health|Family
Interventions: BEHAVIORAL: Optimizing Responses with Collaborative Assessments-Automated (ORCA-A)|BEHAVIORAL: Optimizing Responses with Collaborative Assessments-Live (ORCA-L)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Dose Range Finding Study of JNJ-38518168 in Patients With Active Rheumatoid Arthritis in Spite of Treatment With Methotrexate
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Placebo|DRUG: JNJ-38518168 (3 mg)|DRUG: JNJ-38518168 (10 mg)|DRUG: JNJ-38518168 (30 mg)|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Vitamin D Supplementation and Immune Function
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D - Treatment 1|DIETARY_SUPPLEMENT: Vitamin D - Treatment 2|DIETARY_SUPPLEMENT: Vitamin D - Treatment 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Prospective Randomized Trial of ECP in Subclinical AMR
Status: RECRUITING
Conditions: Antibody-mediated Rejection|Lung Transplant Rejection
Interventions: PROCEDURE: Extracorporeal Photopheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-finding Study Comparing Efficacy and Safety of a PARP Inhibitor Against Doxil in BRCA+ve Advanced Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Neoplasms
Interventions: DRUG: AZD2281|DRUG: Liposomal Doxorubicin|DRUG: AZD2281
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cadonilimab (AK104) Plus Chemotherapy as First-line Treatment in Non-squamous Non-Small Cell Lung Cancer (NSCLC) Patients With Programmed Cell Death Ligand 1 (PD-L1) Negative
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Cadonilimab|DRUG: Pemetrexed|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Effects of MK-3475 (Pembrolizumab) With or Without the Usual Chemotherapy Treatment for Patients 70 Years of Age and Older With Advanced Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Lung Adenocarcinoma|Metastatic Lung Non-Small Cell Carcinoma|Recurrent Lung Adenocarcinoma|Recurrent Lung Non-Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: DRUG: Pembrolizumab|DRUG: Pemetrexed|DRUG: Carboplatin|OTHER: Comprehensive Geriatric Assessment|OTHER: Questionnaire Administration|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib Plus Nivolumab Versus Lenvatinib for Advanced Hepatocellular Carcinoma With Hepatitis B Virus Infection
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Lenvatinib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Two Protocol for Maxillary Molar Intrusion Buccal Miniscrew and TPA Versus Vertical Holding Appliance
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Intrusion|Mandibular Rotation|ANB , SNA, SNB|Openbite Teeth &#X7C; Teeth and Gum &#X7C; Dental
Interventions: BIOLOGICAL: buccal miniscrew and TPA|BIOLOGICAL: vertical holding appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial of Posture Correction Girdle for Adolescents With Early Scoliosis
Status: ENROLLING_BY_INVITATION
Conditions: Scoliosis
Interventions: DEVICE: Posture Correction Girdle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Uterine Fibroids With the Selective Progesterone Receptor Modulator CDB-2914
Status: COMPLETED
Conditions: Leiomyoma
Interventions: DRUG: ulipristal acetate 20 mg|DRUG: ulipristal acetate 10 mg|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Efficacy and Safety Study of Nasal Prongs With Proprietary Surface Coating Aiming to Reduce Bacterial Colonization
Status: COMPLETED
Conditions: Nosocomial Infections|Pneumonia, Ventilator-Associated
Interventions: DEVICE: CytaCoat Nasal Prong|DEVICE: Inspiration Healthcare Inspire nCPAP Nasal Prong
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Aprepitant and Fosaprepitant Time-on-Target PET (Positron Emission Tomography) Study (0869-183)
Status: COMPLETED
Conditions: Chemotherapy-Induced Nausea and Vomiting (CINV)
Interventions: DRUG: Fosaprepitant 150 mg|DRUG: Aprepitant 165 mg|DRUG: Aprepitant 250 mg|DRUG: Dexamethasone (12-8-16-16 mg)|DRUG: Dexamethasone (12-8-8-16 mg)|DRUG: Ondansetron|DRUG: MK0999
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Arbaclofen to Treat Spasticity in Multiple Sclerosis
Status: COMPLETED
Conditions: Spasticity|Multiple Sclerosis
Interventions: DRUG: arbaclofen|DRUG: baclofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Ketoconazole on the Pharmacokinetics of Ibrutinib in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ibrutinib|DRUG: Ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Concentration Oxygen for Pneumocephalus After Evacuation of Chronic Subdural Haematoma
Status: RECRUITING
Conditions: Chronic Subdural Hematoma|Recurrence|Oxycephaly
Interventions: PROCEDURE: High concentration Oxygen therapy|PROCEDURE: Control: Room Air or Low concentration Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing Ipatasertib as Potentially Targeted Treatment in Cancers With AKT Genetic Changes (MATCH - Subprotocol Z1K)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lymphoma|Advanced Malignant Solid Neoplasm|Refractory Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Multiple Myeloma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Ipatasertib|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Time Effect on the Predictability of Different Grafting for Gingival Recession RT 1
Status: COMPLETED
Conditions: Gingival Recession Types One(RT1)
Interventions: COMBINATION_PRODUCT: melatonin with collagen matrix|COMBINATION_PRODUCT: connective tissue graft (CTG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assess the Safety and Efficacy of NKPL66 (CaPre™) in the Treatment of Mild-to-high Hypertriglyceridemia
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DIETARY_SUPPLEMENT: CaPre™|DIETARY_SUPPLEMENT: CaPre™|DIETARY_SUPPLEMENT: CaPre™|DRUG: Lipid Lowering Medication|DIETARY_SUPPLEMENT: CaPre™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Muscle Axis During Treatment of Hepatic Encephalopathy With L-ornithine L-aspartate
Status: COMPLETED
Conditions: Hepatic Encephalopathy|Minimal Hepatic Encephalopathy|Cirrhosis
Interventions: PROCEDURE: Vastus Muscle Biopsy|DRUG: LOLA or placebo|OTHER: Cognitive assessment (PHES)|OTHER: Cognitive Assessement (Cogstate)|OTHER: blood and urine sampling|OTHER: Nutritional assessment|OTHER: MRI brain and spectroscopy|OTHER: MRI leg cross section|OTHER: Functional MRI (working memory and attention tasks)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anterolateral Versus Direct Lateral Approach in Hemiarthroplasty for Hip Fracture
Status: RECRUITING
Conditions: Hip Fractures
Interventions: PROCEDURE: Anterolateral approach|PROCEDURE: Direct lateral approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Penpulimab Combined With Anlotinib and Nab-paclitaxel Plus Gemcitabine as First-line Treatment for Advanced Metastatic Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Adenocarcinoma Metastatic
Interventions: DRUG: Penpulimab|DRUG: Anlotinib|DRUG: Nab paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Muscle Quality Index Improvement by Exercise and HMB Oral Supplementation in Older Adults
Status: NOT_YET_RECRUITING
Conditions: Aging Well
Interventions: OTHER: Power/resistance exercise program|DIETARY_SUPPLEMENT: HMB supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Immunogenicity and Safety of Combined Immunization of COVID-19 Vaccine (Produced in Beijing) and PPV23 / IIV4
Status: COMPLETED
Conditions: Influenza, Human|Pneumonia, Pneumococcal|Covid19
Interventions: BIOLOGICAL: COVAX+IIV4; COVAX+PPV23|BIOLOGICAL: COVAX only (1st and 2nd dose)|BIOLOGICAL: IIV4 for the 1st dose and PPV23 for the 2nd dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Co-administration of Pneumococcal Conjugate Vaccine With DTPa-IPV-Hib Versus Co-administration With DTPa-HBV-IPV/Hib
Status: COMPLETED
Conditions: Infections, Streptococcal
Interventions: BIOLOGICAL: GSK Biologicals´ Pneumococcal Conjugate Vaccine GSK1024850A (Synflorix™)|BIOLOGICAL: Infanrix™ hexa.|BIOLOGICAL: Pediacel™|BIOLOGICAL: Prevenar™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of the Acute Effects of Triheptanoin in Heart Failure
Status: WITHDRAWN
Conditions: Congestive Heart Failure|Non-ischemic Cardiomyopathy
Interventions: DRUG: Triheptanoin oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Spectral Edge Frequency From Spectral EEG Analysis to Guide Deep Sedation in the Critical Care Setting (Pilot)
Status: WITHDRAWN
Conditions: Deep Sedation|Mechanical Ventilation
Interventions: DEVICE: Sedation guided by SEF95 (10-13 Hz) from SedLine® monitor|BEHAVIORAL: Sedation guided by SAS scale (1-2)|DRUG: Deep sedation with propofol andfentanyl|PROCEDURE: Mechanical Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION