pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Orthotics for Treatment of Symptomatic Flat Feet in Children
Status: COMPLETED
Conditions: Pes Planus
Interventions: OTHER: Birthday card|DEVICE: Prefabricated orthoses|OTHER: Signposting to multimedia|OTHER: Usual supportive care - exercises and footwear advice (the comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Tranexamic Acid and Acute Blood Loss in Total Hip Arthroplasty
Status: COMPLETED
Conditions: Acute Blood Loss Anemia|Osteoarthritis, Hip
Interventions: DRUG: Tranexamic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Retrospective Analysis of 2nd-line Nab-Paclitaxel + Gemcitabine After 1st-line FOLFIRINOX in Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer|Metastatic Pancreatic Cancer
Interventions: DRUG: nab paclitaxel plus gemcitabine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: BAY88-8223, Dose Finding Study in Patients With HRPC
Status: COMPLETED
Conditions: Prostate Cancer|Neoplasm Metastasis
Interventions: DRUG: Radium-223 dichloride (BAY88-8223)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ovarian PRP for Diminished Ovarian Reserve
Status: NOT_YET_RECRUITING
Conditions: Diminished Ovarian Reserve
Interventions: OTHER: oPRP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radicava® (Edaravone) Findings in Biomarkers From ALS (REFINE-ALS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis|ALS
Interventions: DRUG: Edaravone (Radicava®/Radicava ORS®)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Integrative Intervention for Loss of Control Eating Among Adolescent Girls
Status: COMPLETED
Conditions: Binge Eating/Loss of Control Eating
Interventions: BEHAVIORAL: Linking Individuals Being Emotionally Real (LIBER8)|BEHAVIORAL: Weight Management Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Management of the Lack of Blood Return on a Central Venous Catheter (CVC) Before Chemotherapy
Status: RECRUITING
Conditions: Catheter Dysfunction
Interventions: PROCEDURE: Physiological serum injection|PROCEDURE: Contrast agent injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving the Treatment of Anorexia Nervosa in Children Through Virtual Reality Body Exposure
Status: RECRUITING
Conditions: Anorexia Nervosa
Interventions: BEHAVIORAL: Attentional Bias Modification Training|BEHAVIORAL: VR-based body exposure|BEHAVIORAL: Cognitive-behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Oral EX039 in Subjects With Mild Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: EX039|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fulvestrant With or Without Lapatinib in Treating Postmenopausal Women With Stage III or Stage IV Breast Cancer That is Hormone Receptor-Positive
Status: COMPLETED
Conditions: Estrogen Receptor Positive|HER2 Positive Breast Carcinoma|HER2/Neu Negative|Progesterone Receptor Positive|Recurrent Breast Carcinoma|Stage IIIB Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7|Stage IV Breast Cancer AJCC v6 and v7
Interventions: DRUG: Fulvestrant|OTHER: Laboratory Biomarker Analysis|DRUG: Lapatinib Ditosylate|OTHER: Placebo Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Levetiracetam in Patients With Primary Brain Tumors and Symptomatic Seizures Who Undergo Surgery
Status: COMPLETED
Conditions: Primary Brain Tumor|Epilepsy
Interventions: DRUG: levetiracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thrombosomes® in Bleeding Thrombocytopenic Patients
Status: COMPLETED
Conditions: Thrombocytopenia|Hematologic Diseases|Bone Marrow Aplasia
Interventions: BIOLOGICAL: Thrombosomes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Telehealth Services on Mental Health Outcomes for People With Intellectual and Developmental Disabilities
Status: RECRUITING
Conditions: Mental Health Conditions|Developmental Disability
Interventions: OTHER: Intake and quarterly assessment:|OTHER: Consultation & coping skills coaching:|OTHER: 24-hour urgent crisis response and intervention:|OTHER: Service linkages, referrals, outreach, & training:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study to Evaluate the Efficacy of XW003 Compared With Placebo in T2DM Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: T2DM|Type 2 Diabetes Mellitus
Interventions: DRUG: Ecnoglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Ranging Study of Combined Haemophilus Influenzae Type B-Meningococcal Serogroups CY (Hib-MenCY-TT) Vaccine
Status: COMPLETED
Conditions: Haemophilus Influenzae Type b|Neisseria Meningitidis
Interventions: BIOLOGICAL: Hib-MenCY-TT vaccine (MenHibrix)|BIOLOGICAL: Meningitec®|BIOLOGICAL: ActHIB®|BIOLOGICAL: Infanrix® Penta|BIOLOGICAL: Prevenar®|BIOLOGICAL: Mencevax® ACWY|BIOLOGICAL: PRP (Polyribosyl Ribitol Phosphate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: "Community-based, eHealth Supported Management of Cardiovascular Risk Factors by Lay Village Health Workers (ComBaCaL aHT TwiC 1 & ComBaCaL aHT TwiC 2)
Status: RECRUITING
Conditions: Arterial Hypertension
Interventions: DRUG: First-line antihypertensive single-pill combination (SPC)|OTHER: Standardized counselling and referral to the closest health facility
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Evaluate the Effects of a Weight Management Program on Body Weight
Status: COMPLETED
Conditions: Body Weight
Interventions: DIETARY_SUPPLEMENT: Weight Management Formulation|DIETARY_SUPPLEMENT: Placebo|OTHER: Handout with Suggestions for Healthy Eating and Overall Health|OTHER: Handout with Suggestions for Healthy Eating and Overall Health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Definitive Chemo-Radiotherapy for Regionally Advanced Head and Neck Cancer With or Without Up-front Neck Dissection
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Neoplasms
Interventions: PROCEDURE: up-front neck dissection|RADIATION: radiotherapy|DRUG: Chemotherapy (Cisplatin)|PROCEDURE: Early Salvage Neck Dissection in case of less than cCR (Arm A only)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intensive Induction Therapy Followed by High Dose Chemo and BM Transplant for Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Mantle Cell Lymphoma
Interventions: PROCEDURE: Intensive Induction-BMT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lactoferrin + Vitamin E + Zinc for Hormonal Acne
Status: UNKNOWN
Conditions: Hormonal Acne
Interventions: DIETARY_SUPPLEMENT: Lactezin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Benralizumab to Reduce OCS Use in Patients With Uncontrolled Asthma on High Dose Inhaled Corticosteroid Plus LABA and Chronic OCS Therapy
Status: COMPLETED
Conditions: Asthma
Interventions: BIOLOGICAL: Benralizumab|BIOLOGICAL: Placebo|BIOLOGICAL: Benralizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability and Food Effect Study of TKI258 (CSF Capsules vs. FMI Capsules)in Adult Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Neoplasms|Cancer|Tumors
Interventions: DRUG: TKI258 (dovitinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dexmedetomidine to Cognition of Geriatrics in Prolonged Surgery
Status: UNKNOWN
Conditions: Cognitive Ability, General|Brain Injury
Interventions: DRUG: Induction of anesthesia|PROCEDURE: Intubation|DRUG: Sevoflurane, remifentanil ,vecuronium|DRUG: Dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Assessment at Peri-implant Tissues After Immediate Implants With Customized Healing Abutments and Connective Tissue Grafts
Status: COMPLETED
Conditions: Dental Implant Failed
Interventions: PROCEDURE: Immediate dental implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Telerehabilitation in Total Knee Arthroplasty
Status: RECRUITING
Conditions: Knee Osteoarthritis|Total Knee Arthroplasty
Interventions: OTHER: Telerehabilitation|OTHER: Standard Home Based Exercise Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mexiletine for the Treatment of Muscle Cramps in ALS
Status: COMPLETED
Conditions: Muscle Cramps in Amyotrophic Lateral Sclerosis
Interventions: DRUG: Mexiletine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low Dose Hyperbaric Bupivacaine and Dexmedetomidine as an Adjuvant, Caesarean Section
Status: COMPLETED
Conditions: Cesarean Section|Spinal Anesthesia|Dexmedetomidine
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is Treatment of Vitamin D Deficiency Associated With Resolution of Statin-Induced Muscular Symptoms
Status: COMPLETED
Conditions: Myopathic Symptoms
Interventions: DRUG: Ergocalciferol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Leveraging Chatbot to Improve PrEP in the Southern United States
Status: NOT_YET_RECRUITING
Conditions: HIV Prevention|PrEP Awareness|PrEP Uptake
Interventions: DEVICE: A chatbot designed to promote PrEP awareness and uptake for Black MSM|OTHER: General educational messages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study the Safety and Efficacy of DBI-001 Gel Versus Aqueous Gel
Status: TERMINATED
Conditions: Atopic Dermatitis
Interventions: BIOLOGICAL: DBI-001|BIOLOGICAL: Aqueous gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrated Intervention for Substance Abusers With Depressive Disorders
Status: COMPLETED
Conditions: Substance-Related Disorders|Depressive Disorder
Interventions: BEHAVIORAL: Twelve Step Facilitation|BEHAVIORAL: Integrated Cognitive Behavioral Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fat and Transcapillary Insulin Transport
Status: COMPLETED
Conditions: Lipid-induced Insulin Resistance
Interventions: OTHER: Elevation of FFA during OGTT|OTHER: Elevation of FFA during Clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Does Intensive Acid Suppression Reduce Esophageal Inflammation and Recurrent Barrett's Esophagus Following Ablation?
Status: COMPLETED
Conditions: Inflammation|Barrett's Esophagus
Interventions: DRUG: dexlansoprazole|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intensive Multidisciplinary Rehabilitation and Biomarkers in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease|Biomarkers|Rehabilitation Outcome|Gait Disorders, Neurologic|Parkinsonian Disorders|Basal Ganglia Diseases|Central Nervous System Diseases|Movement Disorders|Synucleinopathies|Neurodegenerative Diseases|Cognitive Impairment|Gait Analysis|Pathologic Processes|Magnetic Resonance Imaging|Physiotherapy
Interventions: BEHAVIORAL: Multidisciplinary Intensive Rehabilitation|BEHAVIORAL: Muscle-stretching and active mobilization exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of MEDI7352 in Painful Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Chronic Pain
Interventions: BIOLOGICAL: MEDI7352 for IV infusion|BIOLOGICAL: Placebo for IV infusion|BIOLOGICAL: MEDI7352 for Subcutaneous Injection|BIOLOGICAL: Placebo for Subcutaneous Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Assessing the Feasibility of a Novel Non-Invasive Sensor for Guiding Wounded Warrior Rehabilitation
Status: COMPLETED
Conditions: Rehabilitation Post-amputation
Interventions: DEVICE: Near-Infrared Spectroscopy (NIRS) Sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Association Between Systemic Exposure of Atorvastatin and Metabolites and Atorvastatin-induced Myotoxicity
Status: COMPLETED
Conditions: Myopathy
Interventions: DRUG: Atorvastatin (Lipitor)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ketamine Reduces Tourniquet Pain In Patients Undergoing Lower Limb Surgery Under Spinal Anaesthesia
Status: UNKNOWN
Conditions: Tourniquet Pain
Interventions: DRUG: Ketamine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nissen and Gastroplasty in Gastroesophageal Reflux Disease (GERD)
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease|Hiatal Hernia|Barrett's Esophagus|Esophagitis|Dysphagia
Interventions: PROCEDURE: Nissen|PROCEDURE: Gastropexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: lorazepam|DRUG: diphenhydramine hydrochloride|DRUG: haloperidol|OTHER: questionnaire administration|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Adaptive Symptom Self-Management Immunotherapy Study
Status: RECRUITING
Conditions: Breast Cancer|Colon Cancer|Lung Cancer|Skin Cancer|Rectum Cancer
Interventions: BEHAVIORAL: Automated Telephone Symptom Management (ATMS) and Telephone Interpersonal Counseling (TIP-C)|BEHAVIORAL: Active control comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Natural Killer Cells in Patients With Metastatic Prostate Cancer: Relationship With Survival and Response Time to Castration
Status: UNKNOWN
Conditions: Metastatic Prostate Cancer
Interventions: OTHER: Blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Venetoclax in Combination With ASTX727 for the Treatment of Treatment-Naive High-Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia
Status: RECRUITING
Conditions: Chronic Myelomonocytic Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: Decitabine and Cedazuridine|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AI for Colorectal Polyp Detection in Endoscopy
Status: UNKNOWN
Conditions: Focus of the Study is to Evaluate a New Developed Deep-learning Computer-aided Detection System in Combination With LCI for Colorectal Polyp Detection
Interventions: OTHER: CAD with LCI for colorectal polyp detection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Tadalafil vs. Placebo for Improving Hemodynamics and End-Organ Dysfunction in Fontan Physiology
Status: RECRUITING
Conditions: Fontan Palliation
Interventions: DRUG: Tadalafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Predictive Biomarkers of Response to Checkpoint Inhibitors in Triple Negative Breast Cancer: a Multiomics Platform
Status: RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: DIAGNOSTIC_TEST: Whole Genome Sequencing|DIAGNOSTIC_TEST: RNA-Sequencing|DIAGNOSTIC_TEST: Microbiome analysis|DIAGNOSTIC_TEST: ctDNA analysis|DIAGNOSTIC_TEST: TCR-β repertoire sequencing|DIAGNOSTIC_TEST: PBMCs phenotyping|DRUG: Pembrolizumab|DRUG: Chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: De-Intensification Radiotherapy Postoperative Head Neck
Status: UNKNOWN
Conditions: Cancer of Head and Neck
Interventions: RADIATION: A: De-Intensification RT primary tumor region|RADIATION: B: De-Intensification RT contralateral lymph nodes|RADIATION: C. De-Intensification RT primary tumor region AND contralateral lymph nodes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home Non Invasive Ventilation (NIV) Treatment for COPD-patients After a NIV-treated Exacerbation
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease|Acute Exacerbation of Chronic Obstructive Airways Disease|Chronic Hypercapnic Respiratory Failure
Interventions: DEVICE: LTNIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PEEK Versus Silicon Interspinous Spacer for Reduction of Supradjacent Segment Degeneration
Status: COMPLETED
Conditions: Adjacent Segment Degeneration
Interventions: PROCEDURE: PEEK interspinous spacer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Bortezomib,Lenalidomide,Dexamethasone & Elotuzumab in Newly Diagnosed MM
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Lenalidomide|DRUG: Elotuzumab|DRUG: Bortezomib|DRUG: Dexamethasone|PROCEDURE: Stem Cell Mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AB-1015, an Integrated Circuit T (ICT) Cell Therapy in Patients With Platinum Resistant Epithelial Ovarian Cancer
Status: RECRUITING
Conditions: Carcinoma, Ovarian Epithelial|Ovarian Neoplasms|Fallopian Tube Neoplasms|Peritoneal Neoplasms|Neoplasms, Glandular and Epithelial|Ovarian Diseases|Genital Neoplasm, Female|Abdominal Neoplasm|Recurrence
Interventions: BIOLOGICAL: AB-1015
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Surfactants on the Bacterial Composition of the Layers of the Skin
Status: WITHDRAWN
Conditions: Focus: Healthy Skin Microbiome
Interventions: OTHER: Soap 300000027003|OTHER: Soap 300000029240
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Rapamycin as a Means of Interference With Reconsolidation of Posttraumatic Stress Disorder-related Traumatic Memory
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: Rapamycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of IRM and Autopsy in the Evaluation of Intra Uterine Fetal Death
Status: TERMINATED
Conditions: Spontaneous Intra Uterine Fetal Death
Interventions: OTHER: Comparaison between MR and autopsy in the macroscopic evaluation of intra uterine death.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Vascular Dysfunction in Black Individuals: Roles of Nitric Oxide and Endothelin-1
Status: TERMINATED
Conditions: Vascular Function|Racial Disparity
Interventions: DIETARY_SUPPLEMENT: Dietary Nitrates 400 mg|DIETARY_SUPPLEMENT: L-citrulline 3 g|DRUG: Sildenafil 100 mg|DRUG: Bosentan 125 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Defining the Genetics, Biomarkers and Outcomes for Dilated Cardiomyopathy
Status: RECRUITING
Conditions: Dilated Cardiomyopathy|Cardiovascular Diseases
Interventions: OTHER: Part 1: DCM Cohort|OTHER: Part 2: Heritable CV Diseases and Family Members
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of PICOLIGHT Plus COOLPREP, PICOLIGHT Plus CLICOLON for Bowel Preparation
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Picolight + Coolprep|DRUG: Picolight + Clicolon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Asthma and Obesity Diet Versus Exercise
Status: COMPLETED
Conditions: Obesity, Childhood|Asthma in Children|Inflammatory Response|Metabolic Syndrome|Nutrition Poor|Physical Activity|Behavior, Eating|Molecular Biology, Restriction Fragment Length Polymorphisms|Maternal Exposure|Genetic Change
Interventions: BEHAVIORAL: Lifestyle counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of a Single Dose of SRP-5051 (Vesleteplirsen) in Patients With Duchenne Muscular Dystrophy (DMD)
Status: COMPLETED
Conditions: Muscular Dystrophy, Duchenne
Interventions: DRUG: SRP-5051
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Adverse Events and Change in Disease Activity With the XEN45 Glaucoma Treatment System Implantation In Adult Participants With Open-Angle Glaucoma in China
Status: RECRUITING
Conditions: Open-angle Glaucoma|OAG
Interventions: DEVICE: XEN45 Glaucoma Treatment System|PROCEDURE: Trabeculectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus|Idiopathic Inflammatory Myopathy|Systemic Sclerosis
Interventions: DRUG: CC-97540|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Topical Treatment With Clobetasol in Symptomatic Oral Lichen Planus.
Status: RECRUITING
Conditions: Oral Lichen Planus
Interventions: DRUG: Clobetasol Propionate|DRUG: Placebo/Klobetasol APL oral gel 0.025%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tofacitnib for the Treatment of Alopecia Areata and Variants
Status: COMPLETED
Conditions: Alopecia Areata (AA)|Alopecia Totalis (AT)|Alopecia Universalis (AU)
Interventions: DRUG: Tofacitinib Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Allopurinol to Improve Heart Function in Individuals With Dilated Cardiomyopathy
Status: WITHDRAWN
Conditions: Cardiovascular Diseases|Cardiomyopathy, Dilated|Heart Diseases|Heart Failure, Congestive
Interventions: DRUG: Allopurinol|DRUG: Dobutamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Construction and Application Research of Home Cardiac Rehabilitation Plan for Patients Undergoing Transcatheter Aortic Valve Replacement Based on Mobile Healthcare
Status: RECRUITING
Conditions: Transcatheter Aortic Valve Replacement Surgery
Interventions: BEHAVIORAL: A home rehabilitation program centered on exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Influence of Educational Stimuli From the Pé-de-Meia Program on Delay Discounting Propensity
Status: NOT_YET_RECRUITING
Conditions: Delay Discounting
Interventions: BEHAVIORAL: School Retention and Completion Incentive Savings via Modified Iowa Gambling Task A|BEHAVIORAL: Iowa Gambling Task|BEHAVIORAL: School Retention and Completion Incentive Savings via Modified Iowa Gambling Task B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extra-Corporeal Carbon Dioxide Removal in Exacerbations of Chronic Obstructive Pulmonary Disease
Status: UNKNOWN
Conditions: Respiratory Failure With Hypercapnia
Interventions: PROCEDURE: HFNCOT+ECCO2R
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Effects of CLAG With Gleevec in Refractory or Relapsed Acute Myeloid Leukemia
Status: WITHDRAWN
Conditions: Chronic Myeloid Leukemia, Blast Crisis|Acute Myeloid Leukemia
Interventions: DRUG: Imatinib Mesylate|DRUG: CLAG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Analgesia in Laminectomy
Status: UNKNOWN
Conditions: Postoperative Pain|Postoperative Laminectomy Pain
Interventions: DRUG: 550 mg naproxen sodium and 30mg codeine|DRUG: 300 mg paracetamol and 30 mg codeine|DRUG: placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel Therapeutic Drug Monitoring in Cancer Patients
Status: RECRUITING
Conditions: Solid Tumor, Adult|Metastatic Nonsmall Cell Lung Cancer|Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Cervical Carcinoma|Metastatic Ovarian Carcinoma|Malignant Uterine Neoplasm|Vulvar Cancer|Invasive Breast Cancer|Metastatic Breast Carcinoma|Prognostic Stage IV Breast Cancer AJCC v8|Recurrent Breast Carcinoma|Recurrent Cervical Carcinoma|Recurrent Lung Non-Small Cell Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Vulvar Carcinoma|Stage IV Cervical Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IV Vulvar Cancer AJCC v8|Stage IV Ovarian Cancer AJCC v8|Stage IVA Cervical Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVA Ovarian Cancer AJCC v8|Stage IVA Vulvar Cancer AJCC v8|Stage IVB Cervical Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8|Stage IVB Ovarian Cancer AJCC v8|Stage IVB Vulvar Cancer AJCC v8|Vulva Squamous Cell Carcinoma
Interventions: OTHER: Blood draws|OTHER: QLQ-CIPN20 Survey|OTHER: PR-CTCAE Survey
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Feasibility Study Evaluating the Performance of Focused Multipolar Stimulation and Sound Coding in Adults.
Status: RECRUITING
Conditions: Hearing Impairment, Sensorineural
Interventions: DEVICE: Focused Multipolar Stimulation (FMS) strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First in Human Study to Assess the Safety, Tolerability and Pharmacokinetics of EDI048 in Healthy Volunteers
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: EDI048|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Stemchymal® in Polyglutamine Spinocerebellar Ataxia
Status: COMPLETED
Conditions: Cerebellar Ataxia
Interventions: BIOLOGICAL: Stemchymal®|PROCEDURE: Excipients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Compare the Effects of Preoperative Pulmonary Rehabilitation Exercises on Postoperative Anxiety and Muscle Strength
Status: COMPLETED
Conditions: Lung Neoplasm
Interventions: OTHER: Preoperative and postoperative pulmonary rehabilitation exercise|OTHER: Preoperative education and postoperative exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of ABT-199 in Female Patients With Systemic Lupus Erythematosus (SLE)
Status: COMPLETED
Conditions: Lupus Erythematosus
Interventions: DRUG: ABT-199|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: "Evidence of the Use of Virtual Reality Versus Manual Therapy and Therapeutic Exercise in Rotator Cuff Injury"
Status: NOT_YET_RECRUITING
Conditions: Rotator Cuff Injuries
Interventions: OTHER: manual therapy and therapeutic exercise|OTHER: manual therapy and therapeutic exercise and virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CM-24 (MK-6018) Alone and In Combination With Pembrolizumab (MK-3475) in Participants With Selected Advanced or Recurrent Malignancies (MK-6018-001)
Status: TERMINATED
Conditions: Non-small Cell Lung Carcinoma (NSCLC)|Melanoma|Bladder Cancer|Colorectal Cancer|Gastric Cancer|Ovarian Cancer
Interventions: BIOLOGICAL: CM-24 (MK-6018)|BIOLOGICAL: Pembrolizumab (MK-3475)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Tafamidis For The Transthyretin Amyloid Polyneuropathy Patients With V30M Or Non-V30M Transthyretin
Status: COMPLETED
Conditions: Transthyretin Familial Amyloid Polyneuropathy
Interventions: DRUG: tafamidis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiologic Signals and Signatures With the Accuryn Monitoring System (The Accuryn Registry)
Status: COMPLETED
Conditions: Acute Kidney Injury|Abdominal Compartment Syndrome|Intraabdominal Hypertension|Cardiovascular Surgery
Interventions: DEVICE: Accuryn Monitoring System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Impact Through AI-assisted MS Care - A Retrospective Multi-center Observational Study.
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis|NMO Spectrum Disorder|Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease|Radiologically Isolated Syndrome|Clinically Isolated Syndrome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transcriptomic Profile of Adipose Tissue Following n-3 Polyunsaturated Fatty Acid (PUFA) Supplementation
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DIETARY_SUPPLEMENT: LC n-3 PUFA (fish oil) Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The NetherLands Registry of Invasive Coronary Vasomotor Function Testing (NL-CFT)
Status: ENROLLING_BY_INVITATION
Conditions: Coronary Vasospasm|Coronary Microvascular Dysfunction|Non-Obstructive Coronary Atherosclerosis
Interventions: DIAGNOSTIC_TEST: Coronary Function Test|OTHER: Patient questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Aprepitant's Effect on Drug Metabolism in Multi-Day Combination (CHOP/R-CHOP) Chemotherapy Regimen in Lymphoma Patients
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Aprepitant|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone|DRUG: Rituximab|DRUG: Ondansetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dacarbazine and Ipilimumab vs. Dacarbazine With Placebo in Untreated Unresectable Stage III or IV Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Ipilimumab|DRUG: Placebo|DRUG: Dacarbazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Memory Inhibition and Delayed Onset Post-traumatic Stress Disorder in Older Subjects
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder in Old Age
Interventions: OTHER: Post Traumatic Stress Disorder
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial of Sacituzumab Govitecan in Participants With Refractory/Relapsed Metastatic Triple-Negative Breast Cancer (TNBC)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Sacituzumab govitecan|DRUG: Eribulin|DRUG: Capecitabine|DRUG: Gemcitabine|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adaptation of an Intervention Addressing Barriers to PrEP Use Among Pregnant Women in Zimbabwe
Status: NOT_YET_RECRUITING
Conditions: HIV Infections|Pregnancy Related|Depression, Anxiety
Interventions: BEHAVIORAL: TENDAI4PrEP|OTHER: Enhanced treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TAP Block vs LAWI for Analgesia Post-cesarean Section
Status: COMPLETED
Conditions: Obstetric Pain|Obstetric Anesthesia Problems
Interventions: PROCEDURE: Transversus Abdominis Plane Block|PROCEDURE: Local anesthetic wound infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chemotherapy Followed by Allogeneic Stem Cell Transplantation for Hematologic Malignancies
Status: COMPLETED
Conditions: Hematologic Malignancies
Interventions: PROCEDURE: Stem Cell Transplant|DRUG: G-CSF|DRUG: Fludarabine|DRUG: cyclophosphamide|DRUG: Cyclosporine|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7020322 Following Oral Administration in Healthy Participants and Chronic Hepatitis B Patients
Status: TERMINATED
Conditions: Hepatitis B, Chronic
Interventions: OTHER: Matching Placebo|DRUG: RO7020322
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Tranexamic Acid on Blood Loss During Percutaneous Nephrolithotomy.
Status: UNKNOWN
Conditions: Renal Stones|Nephrolithiasis
Interventions: DRUG: Tranexamic acid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TAMO Therapy Versus Postural Control Exercise in Children With Congenital Muscular Torticollis
Status: COMPLETED
Conditions: Torticollis Congenital
Interventions: BEHAVIORAL: TAMO|BEHAVIORAL: Postural Control exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation of Physical Restraints Clinical Practice Guidelines for Critically Ill Patients Using the CAN-IMPLEMENT Framework
Status: UNKNOWN
Conditions: Restraint, Physical|Intensive Care Units|Practice Guideline|Health Plan Implementation
Interventions: OTHER: Select and Tailor implementation interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment of the Link Between Monomeric Functional Form Plasma Level of Vasostatin-1 and Occurrence of New Onset Atrial Fibrillation in Severe Intensive Care Patients
Status: UNKNOWN
Conditions: Atrial Fibrillation|Shock
Interventions: OTHER: VS-I dosing in plasma samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Topical YR001 Ointment in Adult With Mild to Moderate Atopic Dermatitis
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: YR001 ointment|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dermal Thermometry and Self-Care of High Risk Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus|Ulcer|Diabetic Polyneuropathy
Interventions: DEVICE: personal dermal thermometer (DT)|DEVICE: Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Pilot Study Evaluating 18F-L-Thymidine (FLT) PET Imaging in Children With Gliomas
Status: WITHDRAWN
Conditions: Ependymoma|Brainstem Glioma|Astrocytoma|Glioblastoma Multiforme|PNET
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: High-Dose Chemotherapy, Total-Body Irradiation, and Autologous Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Hematologic Cancer or Solid Tumors
Status: COMPLETED
Conditions: Breast Cancer|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Testicular Germ Cell Tumor|Unspecified Adult Solid Tumor, Protocol Specific|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: busulfan|DRUG: carboplatin|DRUG: carmustine|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: melphalan|DRUG: thiotepa|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The ReVo Study: Low-volume vs High-volume Rectal Irrigation
Status: RECRUITING
Conditions: Constipation - Functional|Constipation|Constipation by Outlet Obstruction|Defecation Disorder
Interventions: DEVICE: Rectal Irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retrospective Study Collecting Neurological Follow-up of Hereditary Transthyretin Amyloidosis (ATTRv) Patients Included in B3461028 and B3461045.
Status: COMPLETED
Conditions: Hereditary Transthyretin Amyloidosis (ATTRv)|Polyneuropathy
Interventions: DRUG: Tafamidis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Olmesartan and an add-on Treatment in Patients With Mild to Moderate Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: olmesartan medoxomil + hydrochlorothiazide, if necessary + amlodipine, if necessary
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacist Guided Pre-emptive Pharmacogenetic Testing in Antidepressant Therapy
Status: RECRUITING
Conditions: Depression
Interventions: PROCEDURE: Pharmacist-guided pharmacogenetic (PGx) testing for antidepressant selection and dosing|PROCEDURE: Standard care antidepressant selection and dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Psoriasis Plaque Test Study With LEO 90100 Cutaneous Spray, Ointment, in Psoriasis Vulgaris
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: LEO90100 cutaneous spray, ointment|DRUG: LEO 90100 cutaneous spray, ointment, vehicle with betamethasone dipropionate|DRUG: LEO 90100 cutaneous spray, ointment, vehicle|DRUG: Daivobet® ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose:
Clinical trial: The Separate and Combined Effects of Long-term GIP and GLP-1 Receptor Activation in Patients With Type 2 Diabetes
Status: RECRUITING
Conditions: Type 2 Diabetes|Obesity
Interventions: DRUG: Semaglutide 1.34 MG/ML [Ozempic]|DRUG: Glucose-dependent insulinotropic polypeptide (GIP)|OTHER: Semaglutide 1.34 mg/ml placebo|OTHER: GIP placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Venetoclax and Alvocidib in Patients With Relapsed/Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)
Interventions: DRUG: Venetoclax|DRUG: Alvocidib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dance and Movement Therapy Techniques in Elderly People
Status: COMPLETED
Conditions: Dance Therapy|Self Neglect|Loneliness
Interventions: BEHAVIORAL: walking group: 1.group|BEHAVIORAL: dance and movement therapy group: 2.group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Determining the Effect of Spironolactone on Electrolyte Supplementation in Preterm Infants With Chronic Lung Disease
Status: UNKNOWN
Conditions: Chronic Lung Disease|Bronchopulmonary Dysplasia
Interventions: DRUG: Spironolactone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)
Status: NOT_YET_RECRUITING
Conditions: Acute Respiratory Distress Syndrome|Infections
Interventions: DRUG: Rhu-pGSN|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Magnetic Fields for Treatment of Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DEVICE: The Resonator|DEVICE: The Resonator control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Tolerability, and Efficacy of GS-0976 in Adults With Nonalcoholic Steatohepatitis
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis (NASH)
Interventions: DRUG: Firsocostat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Eccentric Exercise Versus Eccentric Exercise and Astym for Insertional Achilles Tendinopathy
Status: COMPLETED
Conditions: Insertional Achilles Tendinopathy
Interventions: OTHER: Eccentric Exercise|OTHER: Astym
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT