pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Muscle Energy Technique and Kinesiotaping in Mechanical Sacroiliac Joint Dysfunction
Status: TERMINATED
Conditions: Sacroiliac Joint Dysfunction
Interventions: OTHER: Muscle Energy Technique|OTHER: Kinesiotape application|OTHER: Conventional physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Counter-Regulatory Impairment and the Effect of Microvascular Insulin Transfer in Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: PROCEDURE: Hyperinsulinemic, euglycemic and hypoglycemic clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Clinical Feasibility and Efficacy of Intermittent Use of a Fasting Mimicking Diet in the Treatment of Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Fasting Mimicking diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tactile and Kinaesthetic Stimulation in Neonates With Hyperbilirubinaemia
Status: COMPLETED
Conditions: Neonatal Hyperbilirubinemia
Interventions: OTHER: Massage therapy|OTHER: Kinaesthetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Loss and Energy Metabolism in People With Family History of Type 2 Diabetes.
Status: COMPLETED
Conditions: Sleep|Sleep Deprivation|Insulin Resistance|Type 2 Diabetes
Interventions: OTHER: 5.5-hour bedtime|OTHER: 8.5-hour bedtime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Feasibility and Preliminary Efficacy of a Mindfulness-based Intervention for Children and Young Adults With High Grade or High-Risk Cancer and Their Caregivers
Status: COMPLETED
Conditions: Glioblastomas|Sarcoma|Astrocytoma|Brain Cancer|Leukemia
Interventions: BEHAVIORAL: Enhanced Mindfulness Intervention|BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy Study of Hydroxychloroquine to Treat High-risk Coronary Artery Disease.
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Hydroxychloroquine Sulfate Tablets|DRUG: Placebo Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Go/No-Go Intervention for Weight Loss
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: BEHAVIORAL: food-specific go/no-go computerized training|BEHAVIORAL: nonfood-specific go/no-go computerized training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SJOV vs. HFNO for Hypoxia During Procedural Sedation at High Altitudes
Status: RECRUITING
Conditions: Hypoxia|High Altitude
Interventions: PROCEDURE: SJOV|PROCEDURE: HFNO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Safety and Tolerability of FX201 in Patients With Osteoarthritis of the Knee
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: BIOLOGICAL: FX201
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Thermography to Assess the Affects of Sildenafil Cream, 3.6%
Status: RECRUITING
Conditions: Sexual Arousal Disorder
Interventions: DRUG: Sildenafil|DRUG: Vehicle|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Methodology Study to Validate the Cantharidin Blister Model in Healthy Volunteers
Status: COMPLETED
Conditions: Inflammation
Interventions: DRUG: Cantharidin solution|DRUG: Aspirin|DRUG: Prednisolone|DRUG: Placebo to aspirin|DRUG: Placebo to prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: VR Pilot for Pancreatitis
Status: RECRUITING
Conditions: Chronic Pancreatitis|Recurrent Pancreatitis
Interventions: DEVICE: Gut Directed VR|DEVICE: Sham Control VR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Remission Induction Therapy and Risk-oriented Postremission Strategy for Adult Acute Myelogenous Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia
Interventions: DRUG: cytosine arabinoside
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Demonstrate the Relative Bioavailability of Diclofenac Sodium 75 mg Enteric-Coated Tablets Under Non-Fasting Conditions
Status: COMPLETED
Conditions: Inflammation
Interventions: DRUG: Diclofenac Sodium 75 mg Tablets Under Fasting Conditions (Geneva Pharmaceutical)|DRUG: Diclofenac Sodium 75 mg Tablets Under Fed Conditions (Geneva Pharmaceutical)|DRUG: Voltaren 75 mg Tablets Under Fed Conditions (Geigy Pharmaceuticals)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of AR-13324 in Patients With Elevated Intraocular Pressure
Status: COMPLETED
Conditions: Ocular Hypertension|Open Angle Glaucoma
Interventions: DRUG: AR-13324 Ophthalmic Solution 0.01%|DRUG: AR-13324 Ophthalmic Solution 0.02%|DRUG: AR-13324 Ophthalmic Solution 0.04%|OTHER: AR-13324 Ophthalmic Solution Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea
Status: RECRUITING
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: Propofol sedation|DRUG: Dexmedetomidine sedation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: COMPASSION XT PAS - Post-approval Study of the SAPIEN XT THV in Patients With Pulmonary Valve Dysfunction
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Valve Insufficiency|Pulmonary Valve Stenosis|Heart Defects, Congenital|Congenital Abnormalities|Cardiovascular Diseases|Heart Diseases
Interventions: DEVICE: SAPIEN XT THV
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 3D Versus 2D Laparoscopic Total Gastrectomy With Splenic Hilum Lymph Nodes Dissection
Status: UNKNOWN
Conditions: Splenic Hilum Lymph Nodes Dissection
Interventions: PROCEDURE: 3D Laparoscopic total gastrectomy|PROCEDURE: 2D Laparoscopic total gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ketamine in Children With Severe Brain Injury for Brain Cell Protection
Status: WITHDRAWN
Conditions: Traumatic Brain Injury
Interventions: DRUG: saline|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Escalation Study of E7727, an Oral Cytidine Deaminase Inhibitor With Oral Decitabine in Subjects With Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: Decitabine|DRUG: Cedazuridine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Monitored Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent Exotropia
Status: UNKNOWN
Conditions: Intermittent Exotropia
Interventions: DEVICE: Controlled Intermittent Alternate Occlusion (CIAO ) glasses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Apatinib Plus Etoposide Capsule as the Therapy of Advanced Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Apatinib and Etoposide Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Participants With Low-level Persistent Viremia (ANRS 161 L-VIR)
Status: TERMINATED
Conditions: HIV-1 Infection|Treatment Resistant Disorders|Viremia
Interventions: DRUG: Protease inhibitor|DRUG: Isentress® (raltegravir)|OTHER: Counseling arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxyurea Plus Combination Chemotherapy in Patients With Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: etoposide|DRUG: hydroxyurea|DRUG: vinblastine sulfate|DRUG: vindesine|DRUG: vinorelbine tartrate|PROCEDURE: drug resistance inhibition treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: HMA+DLI vs DLI Preemptive Therapy Based on MRD for AL Undergoing Allo-HSCT
Status: UNKNOWN
Conditions: Minimal Residual Disease,Acute Leukemia, Hypomethylating Agents, Donor Lymphocyte Infusion, Allogeneic Hematopoietic Cell Transplantation
Interventions: COMBINATION_PRODUCT: HMA+DLI|BIOLOGICAL: DLI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Different Doses of Oxfendazole Compared to a Single Dose of Albendazole to Treat Trichuris Trichiura Infection in Adults
Status: NOT_YET_RECRUITING
Conditions: Trichuriasis
Interventions: DRUG: Albendazole|DRUG: Oxfendazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IPREP Study #2: Evaluating Enhanced PrEP Packages for Young Female Sex Workers in Kisumu, Kenya
Status: COMPLETED
Conditions: HIV
Interventions: BEHAVIORAL: Peer Support (PS)|BEHAVIORAL: Reminder and Resource Transfer (RRT)|DRUG: daily oral PrEP (emtricitabine 200 mg/tenofovir 300 mg) [FTC/TDF]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Safety and Immune Response of Novartis Meningococcal ACWY Vaccine In Healthy Adults
Status: COMPLETED
Conditions: Meningococcal Meningitis|Meningococcal Infections
Interventions: BIOLOGICAL: Meningococcal ACWY Polysaccharide Vaccine|BIOLOGICAL: MenACWY CRM (19 to 55 years)|BIOLOGICAL: Meningococcal ACWY Conjugate Vaccine|BIOLOGICAL: Novartis MenACWY Vaccine (56 to 65 Years)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pulmonary Aeration and Muscle Thickening Fraction: Association of Electrical Impedance Tomography and Ultrasound
Status: RECRUITING
Conditions: Bronchiolitis
Interventions: DEVICE: Flow rate evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hydrogen-Rich Water and Exercise-Related Biomarkers in Men and Women Over 50 Years
Status: ACTIVE_NOT_RECRUITING
Conditions: Aging
Interventions: DIETARY_SUPPLEMENT: Supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: GaMA Metric to Quantify Functional Importance of Various Upper Limb Prosthetic Devices
Status: RECRUITING
Conditions: Amputation|Amputation, Traumatic|Amputation; Traumatic, Hand|Amputation; Traumatic, Limb
Interventions: DEVICE: Clinically prescribed prosthesis|DEVICE: Experimental prosthesis - Wrist rotation + 1-DOF|DEVICE: Experimental prosthesis - Wrist rotation + Wrist flexion +1-DOF|DEVICE: Experimental prosthesis - Wrist rotation + Multi DOF hand|DEVICE: Experimental prosthesis - Wrist rotation + wrist flexion + Multi DOF hand
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Traumacel PULVIS and Traumacel ENDO Applicator in the Post-market Surveillance Phase
Status: COMPLETED
Conditions: Bleeding|Surgical Wound
Interventions: DEVICE: Traumacel PULVIS, Traumacel ENDO Applicator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of the Safety, Tolerability, Pharmacokinetics (What the Body Does to the Drug), and Pharmacodynamics (What the Drug Does to the Body) of CNTO 1959 Following a Single Subcutaneous (Under the Skin) Administration in Japanese Participants With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: CNTO 1959|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Escalating Doses of Intravenous Bone Marrow-Derived Mesenchymal Stem Cells in Patients With a New Ischemic Stroke
Status: WITHDRAWN
Conditions: Ischemic Stroke
Interventions: BIOLOGICAL: bone marrow-derived mesenchymal stem cells|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nutraceutical Citrulline in Pregnancy
Status: TERMINATED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: L-Citrulline|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Trial of the Use of Intraperitoneal Local Anaesthetic
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Nebulised Bupivacaine intraperitoneally|DRUG: Normal Saline|DRUG: Injected Bupivacaine intraperitoneally|OTHER: No Intraperitoneal Therapeutics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Cohort Study of Weight Loss and Gliosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity, Gliosis, Weight-Loss
Interventions: BEHAVIORAL: Behavioral Weight Loss Program|PROCEDURE: Roux-en-Y Gastric Bypass or Sleeve Gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: MRI-visible Enlarged Perivascular Spaces and the Alteration of Lymphatic Drainage System in CAA
Status: UNKNOWN
Conditions: Cerebral Amyloid Angiopathy|Intracerebral Hemorrhage
Interventions: DRUG: 1. amyloid PET；2. T807 PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Antibiotic Treatment foLlowing Surgical drAinage of Perianal abScess; the ATLAS Trial
Status: RECRUITING
Conditions: Perianal Fistula|Perianal Abscess|Drain Abscess
Interventions: DRUG: Ciprofloxacin 500 mg|DRUG: Metronidazole 500 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Endotracheal Tube Cuff Pressure in Laparoscopic Abdominal Surgery: Saline vs. Air Inflation
Status: COMPLETED
Conditions: Endotracheal Intubation
Interventions: PROCEDURE: Endotracheal intubation using an endotracheal tube with cuff inflated with air|PROCEDURE: Endotracheal intubation using an endotracheal tube with cuff inflated with saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Onvansertib in Combination With Gemcitabine and Nab-paclitaxel for the Treatment of Patients With Locally-advanced, Unresectable, or Metastatic Pancreatic Ductal Adenocarcinoma
Status: WITHDRAWN
Conditions: Locally Advanced Pancreatic Ductal Adenocarcinoma|Metastatic Pancreatic Ductal Adenocarcinoma|Stage II Pancreatic Cancer AJCC v8|Stage III Pancreatic Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8|Unresectable Pancreatic Adenocarcinoma
Interventions: DRUG: Onvansertib|DRUG: Gemcitabine|DRUG: Nab-paclitaxel|PROCEDURE: Electrocardiography|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|PROCEDURE: Biospecimen Collection|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Extension Study to Evaluate the Long-Term Safety and Efficacy of Reslizumab (3.0 mg/kg) as Treatment for Patients (12 Through 75 Years of Age) With Eosinophilic Asthma
Status: TERMINATED
Conditions: Eosinophilic Asthma
Interventions: DRUG: Reslizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of KX2-391 With Paclitaxel in Patients With Solid Tumors
Status: UNKNOWN
Conditions: Unspecified Adult Solid Tumor, Protocol Specific|Gastric Cancer|Breast Cancer
Interventions: DRUG: KX2-391 and Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vertical Augmentation Using Onlay Versus Inlay Autogenous Graft With Simultaneous Implant Placement.
Status: UNKNOWN
Conditions: Bone Resorption
Interventions: OTHER: assigned intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylaxis Versus On-demand Therapy Through Economic Report
Status: COMPLETED
Conditions: Hemophilia A
Interventions: DRUG: Recombinant Factor VIII (Kogenate FS, BAY14-2222)|DRUG: Recombinant Factor VIII (Kogenate FS, BAY14-2222)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Eltrombopag for Moderate Aplastic Anemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Moderate Aplastic Anemia|Unilineage Bone Marrow Failure Disorders
Interventions: DRUG: Eltrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BLAST MRD AML-2: BLockade of PD-1 Added to Standard Therapy to Target Measurable Residual Disease in Acute Myeloid Leukemia 2- A Randomized Phase 2 Study of Anti-PD-1 Pembrolizumab in Combination With Azacitidine and Venetoclax as Frontline Therapy in Unfit Patients With Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Acute Myeloid Leukemia Post Cytotoxic Therapy|Secondary Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|BIOLOGICAL: Pembrolizumab|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy for Prostate and Oligo-metastatic Lesions in Patients With Low-burden Oligo-metastatic Prostate Cancer
Status: NOT_YET_RECRUITING
Conditions: Oligo-metastatic Prostate Carcinoma
Interventions: RADIATION: hormone and RT|DRUG: ADT combined with abiraterone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Tolerability and Immunogenicity of V504 Administered Concomitantly With GARDASIL (V504-001)(COMPLETED)
Status: COMPLETED
Conditions: Cervical Cancer|Vulvar Cancer|Vaginal Cancer|Genital Warts|Human Papillomavirus Infection
Interventions: BIOLOGICAL: V504|BIOLOGICAL: Comparator: Quadrivalent Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine|BIOLOGICAL: Comparator: Placebo (unspecified)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Dose-Finding Study of Fentanyl (JNS020 QD) 1-Day Transdermal Patch in Participants With Cancer Pain
Status: COMPLETED
Conditions: Pain|Cancer
Interventions: DRUG: Fentanyl 1-day transdermal patch (Titration Phase)|DRUG: Fentanyl 1-day transdermal patch (Double Blind Phase)|DRUG: Fentanyl 3-day transdermal patch (Double Blind Phase)|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label, Adaptive Design, Positron Emission Tomography Study in Healthy Male Participants to Characterize Receptor Occupancy by MIJ821 in the Brain
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: MIJ821
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: EMDR in Adolescents With Bipolar Disorder and History of Trauma
Status: UNKNOWN
Conditions: Bipolar Disorder
Interventions: OTHER: Eye Movement Desensitization and Reprocessing (EMDR) Therapy|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Imaging Tumor-infiltrating T-cells in Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: RADIATION: Zr-89 labelled durvalumab PET/CT|DRUG: Durvalumab (MEDI4736)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mannitol Use During Partial Nephrectomy Prior to Renal Ischemia and Impact on Renal Function Outcomes
Status: COMPLETED
Conditions: Renal Cancer
Interventions: DRUG: mannitol|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Hypothalamic-Pituitary-Adrenal (HPA) Axis as an Effector System in Weight Regulation
Status: COMPLETED
Conditions: Obesity|Addison's Disease
Interventions: DRUG: Hydrocortisone|DIETARY_SUPPLEMENT: Isocaloric Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Compare The Pharmacokinetics of A Pregabalin GLARS-NF1 Tablet 150mg With Immediate Release Formulation and to Assess The Effect of High Fat Diet in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pregabalin 150mg|DRUG: Pregabalin 75mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess the Longterm Safety of Sildenafil Citrate in Patients With Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Sildenafil citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (MK-3475-C93/KEYNOTE-C93/GOG-3064/ENGOT-en15)
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Neoplasms
Interventions: BIOLOGICAL: pembrolizumab|DRUG: carboplatin|DRUG: paclitaxel|DRUG: docetaxel|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digoxin In Treatment of Alcohol Associated Hepatitis
Status: RECRUITING
Conditions: Acute Alcoholic Hepatitis|Chemical and Drug Induced Liver Injury|Alcohol-Induced Disorders|Steatohepatitis Caused by Ingestible Alcohol
Interventions: DRUG: Intravenous digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Antiarrhythmic Drug Therapy and Radio Frequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: Radiofrequency ablation, antiarrhythmic drugs|DRUG: Amiodarone, flecainide, propafenone, quinidine, dofetilide, sotalol, cibenzoline, beta blocking and calcium channel blocking agents and antiarrhythmic drugs|DEVICE: ThermoCool Radiofrequency Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Control During Cervical Dilator Placement Prior to Dilation and Evacuation
Status: COMPLETED
Conditions: Pain Management
Interventions: DEVICE: TENS|DEVICE: Sham TENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate a High Intensity Focused Ultrasound (HIFU) Procedure in Patient With Liver Metastases
Status: UNKNOWN
Conditions: Neoplasm Metastasis
Interventions: PROCEDURE: HIFU|PROCEDURE: HIFU|PROCEDURE: HIFU
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Taurolock for Preventing Bacterial Peritonitis During Renal Insufficiency
Status: COMPLETED
Conditions: Peritonitis|Catheter-related Infections|Renal Insufficiency
Interventions: DEVICE: Taurolock|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: JOURNEY II XR Safety and Effectiveness PMCF
Status: ACTIVE_NOT_RECRUITING
Conditions: Rheumatoid Vasculitis With Rheumatoid Arthritis of Knee|Unilateral Post-Traumatic Osteoarthritis of Knee|Knee Osteoarthritis|Degenerative Arthritis Peripheral Joint|Failed Osteotomies|Failed Unicompartmental Replacement
Interventions: DEVICE: JOURNEY II XR Total Knee System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigation of Potential Retinal Toxicity Associated With Hair Dye Products Containing pPD Type Aromatic Amines
Status: COMPLETED
Conditions: MEK Inhibitor-Associated Serous Retinopathy
Interventions: DEVICE: OCT-B scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety Study of GX-I7 Plus Adjuvant Temozolomide Combination in Patients With Newly Diagnosed Glioblastoma
Status: WITHDRAWN
Conditions: Newly Diagnosed Glioblastoma
Interventions: BIOLOGICAL: GX-I7|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gamification Design in Evidence-Based Education for Clinical Nurses
Status: COMPLETED
Conditions: Nursing Education|Evidence-Based Practice
Interventions: OTHER: Evidence-Based Practice (EBP) Teaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GW815SF For Chronic Obstructive Pulmonary Disease (Chronic Bronchitis, Emphysema)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: fluticasone propionate/salmeterol combination DISKUS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Omalizumab in Cholinergic Urticaria
Status: COMPLETED
Conditions: Cholinergic Urticaria
Interventions: BIOLOGICAL: Active|BIOLOGICAL: Placebo|BIOLOGICAL: Open labeled
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Daratumumab for Polyneuropathy Associated With MGUS
Status: RECRUITING
Conditions: Peripheral Neuropathy|Monoclonal Gammopathy of Undetermined Significance
Interventions: DRUG: Daratumumab and hyaluronidase-fihj
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare Pharmacokinetic, Safety, Tolerability and Immunogenicity of HLX12 and Ramucirumab in Healthy Male Adult Subjects
Status: TERMINATED
Conditions: Healthy Male Volunteers
Interventions: BIOLOGICAL: HLX12|BIOLOGICAL: Cyramza (Ramucirumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Epstein-Barr Virus Reactivation and the Effect of EGCG on Virus Reactivation in Remission Patients
Status: UNKNOWN
Conditions: NPC
Interventions: OTHER: Epigallocatechin Gallate (EGCG)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Fed Study of Albuterol Sulfate Extended-Release Tablets 8 mg and VoSpire® ER Tablets 8 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Albuterol Sulfate Extended-Release Tablets 8 mg|DRUG: VoSpire® ER Tablets 8 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Influence of Routinely Adding Ultrasound Screening in Medical Department
Status: COMPLETED
Conditions: Heart Disease|Dyspnea|Aortic Disease|Kidney Disease|Liver Disease
Interventions: PROCEDURE: Pocket-size ultrasonography|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Soiled Airway Tracheal Intubation and the Effectiveness of Decontamination by Paramedics
Status: COMPLETED
Conditions: Airway Management|Intubation, Intratracheal|Laryngoscopy|Vomiting
Interventions: OTHER: Training in SALAD technique
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Early Sleep Apnea Treatment in Stroke
Status: UNKNOWN
Conditions: Sleep Apnea, Obstructive|Sleep Apnea, Central|Stroke
Interventions: DEVICE: AirCurveTM10 CS PACEWAVE Adaptive-Servo-Ventilator (ResMed Ldt., Australia)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tirofiban and Enoxaparin in High Risk Coronary Intervention
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Enoxaparin|DRUG: Tirofiban|DRUG: unfractionated heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Angiotensin 1-7 as a Therapy in the Treatment of COVID-19
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Angiotensin 1-7
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Graphomotor Intervention Program for Handwriting Difficulties Prevention in Preschool Age
Status: COMPLETED
Conditions: Typical Development|Risk of Dysgraphia|Dysgraphia
Interventions: OTHER: Graphomotor intervention program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mechanisms of Action on Rectal Motricity of Intrarectal Botulinum Toxin Injections
Status: NOT_YET_RECRUITING
Conditions: Fecal Incontinence
Interventions: DRUG: intra-rectal botulinum toxin injections
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of Sacubitril/Valsartan Film-coated Tablets Under Fasting Conditions
Status: NOT_YET_RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: Sacubitril and Valsartan Sodium Tablets 24 mg/26 mg|DRUG: Entresto 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: AFSW Guided DOAC|DRUG: Continuous DOAC therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: iMproving thE DIagnostics And Treatment Of ceRvical Precancer
Status: RECRUITING
Conditions: Cervical Dysplasia|Cervical Disease|Cervical Lesion|Cervical Cancer|Cervical Neoplasm
Interventions: DIAGNOSTIC_TEST: Swede score colposcopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hybrid Simulation in Teaching Clinical Breast Examination
Status: COMPLETED
Conditions: Medical Education|Clinical Breast Examination|Medical Simulation|Standardized Patient
Interventions: BEHAVIORAL: Teaching using Hybrid Simulation of breast examination|BEHAVIORAL: Teaching using traditional method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Retrospective Review of DTG/3TC Versus BIC/F/TAF Across a Multi Clinic Infectious Disease Organization in Southeast United States
Status: RECRUITING
Conditions: Hiv|HIV-1-infection|HIV Infections
Interventions: DRUG: DTG/3TC versus BIC/F/TAF
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tedizolid Tissue Penetration in Diabetic Patients With Wound Infections and Healthy Volunteers Via In Vivo Microdialysis
Status: COMPLETED
Conditions: Diabetes|Wound Infection|Healthy Volunteers
Interventions: DRUG: Tedizolid|PROCEDURE: Microdialysis Catheter Insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Patient-Reported Outcomes Among Women Wtih Gynecological Cancer (The CONNECT Study)
Status: RECRUITING
Conditions: Gynecologic Cancer|Gynecologic Neoplasm|Ovarian Cancer|Endometrial Cancer
Interventions: OTHER: Nurse-led consultations based on electronic patient-reported outcomes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigation of the Effect of Different Term Stretching Exercise on Muscle Elasticity in Two Different Muscle Groups
Status: UNKNOWN
Conditions: Rehabilitation|Muscle Tightness
Interventions: OTHER: Static Stretching Exercise for 10 Seconds|OTHER: Static Stretching Exercise for 30 Seconds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Aflibercept (Eylea®) in the Management of Bevacizumab (Avastin®) Resistant Diabetic Macular Edema
Status: UNKNOWN
Conditions: Diabetic Macular Edema
Interventions: DRUG: Aflibercept Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the add-on Efficacy and Safety of Opicapone 50 mg or an Extra Dose of L-DOPA 100 mg for the Treatment of Wearing-off in Patients With PD
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Ongentys 50mg|DRUG: Madopar Tab. 125 or Perkin Tab. 25-100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraosseous Anesthesia Versus Mandibular Nerve Block in Children
Status: UNKNOWN
Conditions: Dental Anaesthesia
Interventions: OTHER: inferior alveolar nerve block|OTHER: intra-osseous mandibular anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection of Tumor DNA in the Blood of Patients Receiving Standard Therapy for Hormone Receptor-positive (HR+) Non-HER2 Expressing (HER2-) Metastatic Breast Cancer as a Tool to Select Those Who May Benefit From the Next Course of Fulvestrant in Combination With Alpelisib or Ribociclib
Status: RECRUITING
Conditions: Breast Cancer Stage IV
Interventions: DRUG: Alpelisib|DRUG: Ribociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Investigating the Effect of Lu AF35700 on Cardiac Repolarization in Men and Women With Schizophrenia and Schizoaffective Disorder
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Lu AF35700 (10 mg/day)|DRUG: Lu AF35700 (30 mg/day)|DRUG: Quetiapine (Seroquel XR® 800 mg/day)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Corneal Lenticule Implantation in Keratoconus Disease With Relex Smile Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Keratoconus
Interventions: PROCEDURE: Lenticule Implantation in Keratoconus Disease with RELEX Smile Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Remineralisation Efficacy of MI PASTE Plus® and REMIN PRO® for White Spot Lesions in Primary Teeth
Status: COMPLETED
Conditions: White Spot Lesion
Interventions: PROCEDURE: Remin Pro® and MI Paste Plus®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Safety of HF1K16 Injection in Patients With Refractory Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor, Adult
Interventions: DRUG: HF1K16 /Arm 45 mg/m²|DRUG: HF1K16 /Arm 90 mg/m²|DRUG: HF1K16 /Arm 120 mg/m²|DRUG: HF1K16 /Arm 160 mg/m²|DRUG: HF1K16 /Arm 120 mg or 180 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online Pivotal Response Treatment Training in Autism Spectrum Disorder
Status: NOT_YET_RECRUITING
Conditions: Autism Spectrum Disorder|Autism
Interventions: BEHAVIORAL: Pivotal Response Treatment Online (PRT-O) Course
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact Hesperetin in Combination With Sucrose on Blood Glucose Regulation
Status: RECRUITING
Conditions: Blood Glucose Fluctuations|Hunger
Interventions: OTHER: 10% Sucrose|DRUG: Sucrose+ Hesperetin|OTHER: 7% Sucrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tourniquet Pressure in Primary Total Knee Arthroplasty
Status: TERMINATED
Conditions: Tourniquets|Knee Arthroplasty, Total|Knee Replacement, Total
Interventions: PROCEDURE: Tourniquet Cuff Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Perinatal Emotional Management on Maternal Emotion and Delivery Outcomes
Status: COMPLETED
Conditions: Perinatal Problems|Mental Depression|Complications; Cesarean Section
Interventions: BEHAVIORAL: antenatal psychological intervention|BEHAVIORAL: routine prenatal care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An Evaluation of a Gender Specific Insole to Provide Relief From Knee Pain Due to Osteoarthritis or General Anterior Knee Pain in Male Subjects When Used in Foot Wear Over a Period of Four Weeks
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: BPI 1000013 (Dr Scholls Insole)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation (rTMS) for Dystonia and Tremor
Status: COMPLETED
Conditions: Dystonia|Tremor
Interventions: DEVICE: repetitive Transcranial Magnetic Stimulation (rTMS)|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Naxitamab Added to Induction for Newly Diagnosed High-Risk Neuroblastoma
Status: RECRUITING
Conditions: High-risk Neuroblastoma
Interventions: DRUG: Naxitamab|DRUG: Ceritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pioglitazone on Heart Failure in Type-2 Diabetes Mellitus Participants
Status: RECRUITING
Conditions: Type 2 Diabetes Mellitus in Obese|Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Raltegravir (Isentress/MK-0518) and HIV-1 Infected CD4 Cells During Acute/Early HIV-1
Status: TERMINATED
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: 3-drug anti-HIV therapy|DRUG: Raltegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Tranilast Alone or in Combination With Allopurinol in Subjects With Hyperuricemia
Status: COMPLETED
Conditions: Gout|Hyperuricemia
Interventions: DRUG: Tranilast|DRUG: Allopurinol|DRUG: Combination - Tranilast and Allopurinol|DRUG: 400 mg Allopurinol|DRUG: High dose combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing the Effect of Oral Dimenhydrinate Versus Placebo in Children With Gastroenteritis
Status: COMPLETED
Conditions: Gastroenteritis
Interventions: DRUG: Dimenhydrinate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTI
Status: WITHDRAWN
Conditions: Urinary Tract Infections
Interventions: DRUG: Nitrofurantoin|DRUG: Gentamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Rheumatoid Arthritis.
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Coherex WAVECREST I Left Atrial Appendage Occlusion Study
Status: COMPLETED
Conditions: Non-valvular Paroxysmal, Persistent, or Permanent Atrial Fibrillation|LAA Anatomy Amenable to Treatment by Percutaneous Technique|Anticoagulation Indication for Potential Thrombus Formation in the Left Atrium
Interventions: DEVICE: WaveCrest LAA occlusion device
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: NB-001 Treatment of Recurrent Herpes Labialis
Status: UNKNOWN
Conditions: Herpes Labialis
Interventions: DRUG: NB-001 (0.3%)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of JNJ-39439335 in Healthy Japanese and Caucasian Adult Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-39439335 10 mg|DRUG: JNJ-39439335 25 mg|DRUG: JNJ-39439335 50 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Montelukast for Acute Bronchiolitis and Postbronchiolitis Viral Induced Wheezing
Status: COMPLETED
Conditions: Bronchiolitis|Wheezing|Cough
Interventions: DRUG: Montelukast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Needs-focused Palliative Care Intervention for Older Adults in ICUs
Status: COMPLETED
Conditions: Palliative Care|Critical Illness|Aging|Care Delivery Model|Informal Caregivers|Psychological Distress
Interventions: BEHAVIORAL: PCplanner
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Remifentanil and Midazolam on Propofol for Loss of Consciousness in Elderly Patients
Status: UNKNOWN
Conditions: Anesthesia
Interventions: DRUG: Propofol|DRUG: Remifentanil|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: