pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Breast Cancer
Status: WITHDRAWN
Conditions: Advanced Breast Cancer
Interventions: BIOLOGICAL: Activated CIK and CD3-MUC1 Bispecific Antibody in Treating Breast Cancer|PROCEDURE: cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Velcade, Doxil, and Dexamethasone (VDd) as First Line Therapy for Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Velcade|DRUG: Doxil|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Neurocognitive Outcome After Transplant
Status: RECRUITING
Conditions: Stem Cell Transplantation|Pediatric Cancer|Acute Lymphoblastic Leukemia
Interventions: BEHAVIORAL: Cognitive rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Yoga, Mindfulness and Cognitive Psychotherapy as Treatment for Stress and Burnout
Status: COMPLETED
Conditions: Stress, Psychological|Burnout, Professional|Anxiety|Depression
Interventions: BEHAVIORAL: Yoga|BEHAVIORAL: Mindfulness based cog psychotherapy|BEHAVIORAL: Cognitive psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cochlear Implant and Vestibular Function.
Status: UNKNOWN
Conditions: Sensorineural Hearing Loss|Deafness|Hearing Loss
Interventions: PROCEDURE: Round window approach|PROCEDURE: Cochleostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immune Response After SARS-CoV-2 Vaccination in a Context of Non-Hodgkin Lymphoma
Status: UNKNOWN
Conditions: Non-hodgkin Lymphoma,B Cell|Vaccination Failure
Interventions: OTHER: Immunological analyses
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: PictureRx: An Intervention to Reduce Latino Health Disparities (Supplement: Medical Icons)
Status: COMPLETED
Conditions: Understanding of Medication Instructions|Recall of Medication Instructions
Interventions: BEHAVIORAL: Drug indication icons|BEHAVIORAL: Structured instructions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Impact of Limb Remote Ischemic Preconditioning on Mortality and Quality of Life During Abdominal Aortic Aneurysm Repair
Status: UNKNOWN
Conditions: Abdominal Aortic Aneurysm
Interventions: PROCEDURE: limb RIPC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The DISCOVER INOCA Prospective Multi-center Registry
Status: RECRUITING
Conditions: Ischemia and No Obstructive Coronary Artery Disease|Coronary Microvascular Dysfunction|Coronary Vasospasm|Endothelial Dysfunction|Microvascular Angina|Chest Pain With Normal Coronary Angiography
Interventions: DIAGNOSTIC_TEST: Coroventis Coroflow Cardiovascular System and PressureWire™ X Guidewire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: US-Guided SAPB Versus ESPB on Acute and Chronic Pain After VATS
Status: RECRUITING
Conditions: Postoperative Pain|Video-Assisted Thoracoscopic Surgery|Serratus Anterior Plane Block|Erector Spinae Plane Block|Acute Pain|Chronic Pain
Interventions: PROCEDURE: Serratus anterior plane block|PROCEDURE: Erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) in Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Neoplasms
Interventions: DRUG: intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wearable LITUS Device for Osteoarthritis of the Knee: a Randomized Double-Blind Placebo-Controlled Trial
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Sam Ultrasonic Diathermy Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Studying the Relationship Between Contact Lens Packaging Solutions and Bacterial Binding to Surface Eye Cells
Status: WITHDRAWN
Conditions: Corneal Ulcer
Interventions: DEVICE: Contact lens packaging solution|DEVICE: Balanced salt solution (BSS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trehalose as add-on Therapy in Bipolar Depression
Status: COMPLETED
Conditions: Bipolar Disorder|Bipolar Depression
Interventions: DRUG: Trehalose|DRUG: Maltose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy, Safety and Tolerability of N1539
Status: COMPLETED
Conditions: Hysterectomy
Interventions: DRUG: N1539|DRUG: N1539|DRUG: N1539|DRUG: N1539|DRUG: placebo|DRUG: Morphine|DRUG: N1539
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study of ABP-20001 to Evaluate Safety and Efficacy of Repeat Treatments of ABP-450 for Migraine Prevention
Status: ENROLLING_BY_INVITATION
Conditions: Migraine
Interventions: DRUG: ABP-450
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transdiagnostic CBT-I on Comorbid Depression and Insomnia
Status: NOT_YET_RECRUITING
Conditions: Insomnia|Depression
Interventions: BEHAVIORAL: Self-help CBT-I|BEHAVIORAL: Self-help CBT-D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Multi-Institutional Study to Evaluate the Accuracy of a Breast Cancer Locator in Patients With Palpable Cancers
Status: COMPLETED
Conditions: Palpable Breast Cancer
Interventions: DEVICE: Breast Cancer Locator (BCL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study of Participants With Non-Valvular Atrial Fibrillation (NVAF) Treated or Untreated With Oral Anticoagulant in the National Cerebral and Cardiovascular Center (NCVC) in Japan
Status: COMPLETED
Conditions: Non-Valvular Atrial Fibrillation (NVAF)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Resveratrol and Serum Apo A-I
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DIETARY_SUPPLEMENT: Resveratrol capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase Ⅰb Study on Autologous GC101 TIL Injection for the Treatment of NSCLC
Status: NOT_YET_RECRUITING
Conditions: Non Small Cell Lung Cancer Metastatic|Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: Autologous Tumor Infiltrating Lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Awake Prone Positioning for Non-intubated COVID-19 Patients
Status: COMPLETED
Conditions: Prone Position|Coronavirus Disease 2019|Oxygenation
Interventions: PROCEDURE: prone position group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Virtual Reality as a Postoperative Pain Management Adjunct in Older Adults: An Acceptability and Feasibility Study
Status: COMPLETED
Conditions: Aged|Surgery|Pain, Postoperative|Virtual Reality
Interventions: OTHER: REAL System i-Series VR head-mounted display (HMD) from Penumbra, Inc.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Observational Time and Motion Study of Trastuzumab Subcutaneous (SC) and Intravenous (IV) Formulations in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Early Breast Cancer (EBC)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: First-Line Treatment of A Comparison of 2 Treatments in Elderly Patients With Advanced NSCLC
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Pemetrexed|DRUG: Gemcitabine|DRUG: Bevacizumab|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Parent-coached Exposure Therapy for Children With Anxiety Disorders and OCD
Status: COMPLETED
Conditions: Anxiety Disorders|Obsessive-Compulsive Disorder
Interventions: BEHAVIORAL: Parent Coached Exposure Therapy - Individualized|BEHAVIORAL: Cognitive Behavior Therapy|BEHAVIORAL: Parent Coached Exposure Therapy - Group (removed from study)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability, and Processing by the Body of Intravenous and Subcutaneous RO7121932 in Participants With Multiple Sclerosis.
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: RO7121932 IV - SAD|DRUG: RO7121932 SC - SAD|DRUG: RO7121932 - MAD
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultra Low Dose Interleukin-2 in Healthy Volunteers
Status: COMPLETED
Conditions: Hematologic Diseases
Interventions: DRUG: Interleukin-2 (100,00 IU/m(2) SQ)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Amygdala Neurofeedback on Depressive Symptoms
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: BEHAVIORAL: real-time fMRI neurofeedback: Amygdala|BEHAVIORAL: real-time fMRI neurofeedback: HIPS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-operative Steroids in CRSsP
Status: WITHDRAWN
Conditions: Chronic Sinus Disease|Chronic Sinusitis, Ethmoidal|Chronic Sinusitis, Sphenoidal|Chronic Sinusitis - Maxillary Bilateral|Chronic Sinusitis - Frontoethmoidal
Interventions: DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab With Ruxolitinib in Relapsed or Refractory Classical Hodgkin Lymphoma
Status: RECRUITING
Conditions: Hodgkin Lymphoma
Interventions: DRUG: Ruxolitinib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of CVU (Phase IIb)
Status: RECRUITING
Conditions: Skin Ulcer Venous Stasis Chronic
Interventions: BIOLOGICAL: allo-APZ2-CVU|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Triple Therapy of Pars Plana Vitrectomy and Grid/Focal Laser for Diabetic Macular Edema (DME)
Status: COMPLETED
Conditions: Diabetic Retinopathy|Macular Edema
Interventions: PROCEDURE: Triple therapy of vitrectomy, IVTA and grid/focal laser photocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retrospective Study of Brachytherapy
Status: RECRUITING
Conditions: Brachytherapy|Uterine Cervical Neoplasms|Uterine Neoplasms|Vulvar Cancer|Vaginal Cancer|Ovarian Neoplasms|Gynecologic Neoplasm
Interventions: RADIATION: Brachytherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate the Safety, Tolerance, Pharmacokinetics Characteristics of PA3670 Tablets in Chinese Healthy Subjects
Status: COMPLETED
Conditions: Chronic HBV Infection
Interventions: DRUG: PA3670
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Swedish BioFINDER - Primary Care Study
Status: RECRUITING
Conditions: Mild Dementia|Mild Cognitive Impairment|SCD|Alzheimer Disease|Lewy Body Disease|Frontotemporal Degeneration|Vascular Dementia
Interventions: DIAGNOSTIC_TEST: Plasma APS 2 score|DIAGNOSTIC_TEST: Plasma p-tau217/np-tau217|DIAGNOSTIC_TEST: Plasma p-tau217|DIAGNOSTIC_TEST: Plasma neurofilament light (NfL)|DIAGNOSTIC_TEST: Plasma Ab42/Ab40|DIAGNOSTIC_TEST: MRI and CT of the brain|DIAGNOSTIC_TEST: Different cognitive tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Sulforaphane on Cognitive Function in Patients With Frontal Brain Damage
Status: UNKNOWN
Conditions: Frontal Lobe Dysfunction
Interventions: DRUG: sulforaphane|DRUG: placedo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Transplantation Using Mini-Conditioning for Treatment of Stage IV Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: BIOLOGICAL: therapeutic allogeneic lymphocytes|DRUG: cyclophosphamide|DRUG: docetaxel|DRUG: doxorubicin hydrochloride|DRUG: fludarabine phosphate|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proximal Humerus Fracture Dislocation Direction and Avascular Necrosis
Status: COMPLETED
Conditions: Proximal Humeral Fracture|Dislocation|Dislocation Shoulder|Avascular Necrosis|Avascular Necrosis of Humerus
Interventions: DIAGNOSTIC_TEST: X-Ray
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nebulized Albuterol for Congestive Heart Failure Exacerbation
Status: WITHDRAWN
Conditions: Congestive Heart Failure
Interventions: DRUG: Albuterol|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men to Test Whether Zongertinib Affects How 3 Other Medicines (Midazolam, Omeprazole, and Repaglinide) Are Taken up and Processed by the Body
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DRUG: zongertinib|DRUG: midazolam|DRUG: omeprazole|DRUG: repaglinide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beta-Adrenergic Modulation of Drug Cue Reactivity
Status: NOT_YET_RECRUITING
Conditions: Tobacco Use Disorder|Nicotine Dependence|Cigarette Smoking
Interventions: DRUG: Propranolol|DRUG: Nicotine Patch|DRUG: Placebo Propranolol|DRUG: Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of High Doses Penicillin V Versus High Doses Amoxicillin in the Treatment of Non-severe Pneumonia.
Status: TERMINATED
Conditions: Community-acquired Pneumonia (CAP)
Interventions: DRUG: Penicillin V|DRUG: Amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Valsartan/Hydrochlorothiazide Combination vs Amlodipine in Patients With Hypertension, Diabetes, and Albuminuria.
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: valsartan/hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Prostaglandin E2 (PGE2) Inhibition of Acuvail(Ketorolac 0.45%), Xibrom (Bromfenac 0.09%)and Nevanac (Nepafenac)in Patients Undergoing Phacoemulsification
Status: COMPLETED
Conditions: Cataracts
Interventions: DRUG: Ketorolac Tromethamine|DRUG: Bromfenac|DRUG: nepafenac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decreasing the Temporal Window in Individuals With Alcohol Use Disorder
Status: ENROLLING_BY_INVITATION
Conditions: Alcohol Use Disorder
Interventions: BEHAVIORAL: Scarcity Narrative|BEHAVIORAL: Neutral Narrative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: ClariCore System Used in Transrectal Ultrasound Guided Prostate Biopsy for Real-Time Tissue Evaluation
Status: UNKNOWN
Conditions: Cellular Diagnosis, Prostate Cancer
Interventions: DEVICE: ClariCore Optical Biopsy System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Percutaneous Pinning vs Orthosis and Early Mobilization
Status: RECRUITING
Conditions: Hand Injuries|Finger Fracture
Interventions: PROCEDURE: Percutaneous pinning|PROCEDURE: Conservative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Uptake, Break Down and Elimination of an Investigational Drug in Healthy Volunteers
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: AZD3480|DRUG: AZD3480
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Piloting a Web-based Personalised Nutrition App (eNutri) With UK University Students
Status: ACTIVE_NOT_RECRUITING
Conditions: Diet Habit|Diet, Healthy|Diet Modification
Interventions: BEHAVIORAL: eNutri personalised nutrition advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Crosstalk Between Mucosal-Associated Invariant T (MAIT) Cells and the Gut Microbiota and Mucosa in the Development of Type 1 Diabetes in Children
Status: RECRUITING
Conditions: Type1diabetes
Interventions: DIAGNOSTIC_TEST: MAIT cells analysis|DIAGNOSTIC_TEST: MAIT cytokines production analysis|DIAGNOSTIC_TEST: Lactulose/Mannitol Test|PROCEDURE: UGI Endoscopy|DIAGNOSTIC_TEST: Coxsackie virus B infection status|DIAGNOSTIC_TEST: Coxsackie virus B infection status
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Bayesian Basket Trial
Status: NOT_YET_RECRUITING
Conditions: Sepsis
Interventions: DRUG: Tocilizumab|DRUG: Baricitinib|DRUG: Anakinra|DRUG: Hydrocortisone|DRUG: Hydrocortisone and fludrocortisone|DRUG: Heparin|DRUG: Low molecular weight heparin|DRUG: Recombinant humanThrombomodulin( rhTM)|DRUG: Sivelestat|BIOLOGICAL: Fresh frozen plasma|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet-delivered Cognitive Behavior Therapy for Adolescents With Functional Gastrointestinal Disorders: a Pilot Study
Status: COMPLETED
Conditions: Irritable Bowel Syndrome|Functional Gastrointestinal Disorders
Interventions: BEHAVIORAL: Internet-delivered CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brief Interventions for Coping With Distress
Status: RECRUITING
Conditions: Distress, Emotional|Emotional Dysfunction|Anxiety|Depression
Interventions: BEHAVIORAL: Online, Self-Directed Attention Skills Training with Coaching Support|BEHAVIORAL: Online, Self-Directed Attention & Reflective Thought Skills Training with Coaching Support|BEHAVIORAL: Online, Self-Directed Health & Wellness Education Training with Coaching Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer
Status: COMPLETED
Conditions: Graft Versus Host Disease|Leukemia|Lymphoma|Myelodysplastic Syndromes|Neuroblastoma
Interventions: BIOLOGICAL: anti-thymocyte globulin|DRUG: busulfan|DRUG: cyclosporine|DRUG: melphalan|DRUG: methylprednisolone|PROCEDURE: umbilical cord blood transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Epidural Anesthesia for Thoracic and Abdominal Surgery
Status: COMPLETED
Conditions: Analgesia Disorder|Anesthetic Complication Epidural|Adverse Reaction to Epidural Anesthesia
Interventions: PROCEDURE: Elective Thoracic and Abdominal Surgery Patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Diabetes Data-Assisted Remission Trial (DDART)
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 2 Diabetes|Obesity
Interventions: BEHAVIORAL: Medical weight loss|BEHAVIORAL: Diabetes education|BEHAVIORAL: Continuous glucose monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sacituzumab Govitecan in Patients With Metastatic Castration-Resistant Prostate Cancer Progressing on Second Generation AR-Directed Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Sacituzumab Govitecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breast for Success: A Family-Centered Intervention in Support of Breastfeeding Among High-risk Low-income Mothers
Status: COMPLETED
Conditions: Breastfeeding
Interventions: BEHAVIORAL: Enhanced Curriculum|BEHAVIORAL: Enhanced Curriculum+Breastfeeding Doula|BEHAVIORAL: Enhanced Curriculum +Father Support
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Evaluate the Safety and Feasibility of Allogeneic Mesenchymal Stem Cells in Patients With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Secondary-Progressive Multiple Sclerosis|Mesenchymal Stem Cells
Interventions: BIOLOGICAL: Allogenic placenta derived mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Azithromycin in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Chronic Productive Cough
Status: COMPLETED
Conditions: Cough|Chronic Obstructive Pulmonary Disease|Chronic Bronchitis
Interventions: DRUG: azithromycin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Drug Levels of BMS-986165 When Taken as Various Solid Tablet Prototypes by Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Reference Treatment- BMS-986165-01|DRUG: Prototype BMS-986165|DRUG: Famotidine|OTHER: Alcohol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Frailty Score-guided Dosing of Lenalidomide, Dexamethasone and Daratumumab Induction Therapy
Status: WITHDRAWN
Conditions: Multiple Myeloma
Interventions: DRUG: Lenalidomide Pill|DRUG: Dexamethasone|DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Cranberry-Containing Products in Women With Recurrent Urinary Tract Infections (UTIs)
Status: UNKNOWN
Conditions: Urinary Tract Infection
Interventions: DRUG: Cranberry juice|DIETARY_SUPPLEMENT: Cranberry Juice|DIETARY_SUPPLEMENT: Placebo cranberry juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Randomized Clinical Study of "Attempted Suicide Short Intervention Program" in Swedish Healthcare - ASSIP
Status: RECRUITING
Conditions: Suicide, Attempted
Interventions: BEHAVIORAL: ASSIP + treatment as usual|OTHER: Treatment as usual and patient safety
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Walking With Music in Obese People (BeatMove)
Status: RECRUITING
Conditions: Obesity|Sedentary Behavior
Interventions: DEVICE: BeatMove Application|DEVICE: BeatMove Application without synchronized music|DEVICE: BeatMove Application without music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Taxotere/Temodar/Cisplatin Study in Melanoma Patients
Status: COMPLETED
Conditions: Metastatic Melanoma
Interventions: DRUG: Cisplatin|DRUG: Docetaxel|DRUG: Temodar
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imaging and Interventional Study for Erectile Dysfunction and Lower Urinary Tract Symptoms
Status: UNKNOWN
Conditions: Erectile Dysfunction|Lower Urinary Tract Symptoms|Peripheral Arterial Disease
Interventions: DEVICE: drug-eluting balloon|DEVICE: biodegradable vascular scaffold stent|DEVICE: Apex™ PTCA Dilatation Catheter|DEVICE: Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study To Investigate Safety And Efficacy Of Sildenafil In The Newborns With Persistent Pulmonary Hypertension (PPHN)
Status: TERMINATED
Conditions: PPHN|Persistent Pulmonary Hypertension of the Newborn|Hypoxic Respiratory Failure
Interventions: DRUG: sildanefil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Explore the Impacts of One Session Theta Burst Stimulation Over Cerebellum in Adults With Autism Spectrum Disorder
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DEVICE: intermittent theta burst stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity
Status: RECRUITING
Conditions: Breast Cancer|Lung Cancer|Gastrointestinal Cancer|Genitourinary Cancer|Gynecologic Cancer|Sarcoma|Unknown Primary Tumors|Head and Neck Cancer|Skin Cancer
Interventions: DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ⅲ Clinical Trial of Recombinant COVID-19 Trivalent (XBB+BA.5+Delta) Protein Vaccine (Sf9 Cell) in Booster Vaccination
Status: NOT_YET_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: High dose of Recombinant COVID-19 Trivalent (XBB+BA.5+Delta) Protein Vaccine (Sf9 Cell)|BIOLOGICAL: Low dose of Recombinant COVID-19 Trivalent (XBB+BA.5+Delta) Protein Vaccine (Sf9 Cell)|BIOLOGICAL: control group|BIOLOGICAL: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Vaccine To Prevent Cervical Intraepithelial Neoplasia or Cervical Cancer in Younger Healthy Participants
Status: COMPLETED
Conditions: Cervical Cancer|Precancerous Condition
Interventions: BIOLOGICAL: human papillomavirus 16/18 L1 virus-like particle/AS04 vaccine|BIOLOGICAL: hepatitis A inactivated virus vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Telehealth to Reduce Suicidality and Improve HIV Care Engagement in Tanzania
Status: ACTIVE_NOT_RECRUITING
Conditions: Suicide|Suicidal Ideation|HIV Infections|Adherence, Medication|Treatment Adherence and Compliance|Stigma, Social|Disclosure|Quality of Life
Interventions: BEHAVIORAL: IDEAS for Hope|BEHAVIORAL: Enhanced Standard of Care (Safety Planning)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Multiple-dose Tolerability and Pharmacokinetic Studies of Benapenem in Clinical Healthy Subjects
Status: UNKNOWN
Conditions: Multiple-dose Tolerability and Pharmacokinetic Studies of Benapenem in Clinical Healthy Subjects
Interventions: DRUG: Banapenem|DRUG: sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase IIa Repeat Dose AXP1275 vs Placebo Cross-over Trial With Pulmonary Allergen Challenge in Adults With Asthma
Status: COMPLETED
Conditions: Atopic Asthma
Interventions: DRUG: AXP1275|DRUG: AXP1275 matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Neo40(TM) With Caffeine on Cycling Time Trial Performance
Status: UNKNOWN
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Nitrate supplement with caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Effects of Single Dose Corticosteroids on Response to Allergens
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Placebo|DRUG: prednisone|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: S-pantoprazole 10mg Phase III Clinical Study
Status: UNKNOWN
Conditions: Non Erosive Reflux Disease
Interventions: DRUG: S-pantoprazole 10mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing Two Therapies: Basal Insulin/Glargine, Exenatide and Metformin Therapy (BET) or Basal Insulin/Glargine, Bolus Insulin Lispro and Metformin Therapy (BBT) in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: exenatide|DRUG: insulin lispro|DRUG: Metformin|DRUG: Insulin/ Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Anaprazole Sodium Enteric-coated Tablets in the Treatment of Reflux Esophagitis
Status: NOT_YET_RECRUITING
Conditions: Reflux Esophagitis|Gastroesophageal Reflux|Esophagitis|Esophageal Motility Disorders|Deglutition Disorders|Esophageal Diseases|Gastrointestinal Diseases
Interventions: DRUG: Anaprazole sodium 40 mg|DRUG: Anaprazole sodium 60 mg|DRUG: Rabeprazole sodium 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetics, Pharmacodynamics and Safety Study of Rabeprazole in New Born Infants With Gastroesophageal Reflux Disease (GERD)
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DRUG: Rabeprazole sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nimotuzumab in Combination With Radiochemotherapy for Patients With Stage IIIA/IIIB Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: nimotuzumab|DRUG: Cisplatin|DRUG: Etoposide|RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physical Therapists - Recommending EnhanceFitness to Expand Reach
Status: COMPLETED
Conditions: Physical Activity|Aging
Interventions: OTHER: PT-REFER Capacity-building Toolkit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: High Flow Nasal Cannula Versus Nasal Intermittent Positive Pressure (NIPPV) in Preterm Infants
Status: UNKNOWN
Conditions: Preterm Infant
Interventions: OTHER: Vapotherm|OTHER: NIPPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Infant Immunization Encouragement Program in Nigeria
Status: COMPLETED
Conditions: Tuberculosis|Diphtheria|Tetanus|Pertussis|Hepatitis B|Haemophilus Influenzae Type b Infection|Pneumonia, Bacterial|Measles|Rotavirus Infections|Polio|Yellow Fever
Interventions: BEHAVIORAL: All Babies Are Equal Initiative (conditional cash transfer program)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ICULIP, Influence of Two Lipid Emulsions in the Nosocomial Infection in Critical Patients
Status: TERMINATED
Conditions: Critical Illness
Interventions: DRUG: MCT/LCT (1:1)|DRUG: MCT/LCT/omega-3 (5:4:1)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment for Bipolar Depression: Acute & Prophylactic Efficacy With Citalopram
Status: COMPLETED
Conditions: Bipolar Disorder|Bipolar Depression
Interventions: DRUG: citalopram + mood stabilizer|DRUG: placebo + mood stabilizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Abiraterone Prednisone and Hormonal Therapy Before and During Radiation Therapy in Localized Prostate Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Prostate|Stage II Prostate Cancer|Stage III Prostate Cancer|Stage IV Prostate Cancer
Interventions: DRUG: abiraterone acetate|DRUG: prednisone|DRUG: leuprolide acetate|OTHER: laboratory biomarker analysis|RADIATION: external beam radiation therapy|DRUG: goserelin acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ADVANCED FSHD-COM: New Clinical Outcome Measures to Evaluate Non-ambulant FSHD Patients, a Pilot Study
Status: RECRUITING
Conditions: Facioscapulohumeral Muscular Dystrophy
Interventions: DIAGNOSTIC_TEST: Validation of new COMs for non ambulant FSHD patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacological Profile of Different Berberine Formulations, and Effects on Blood Sugar Levels
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DIETARY_SUPPLEMENT: Berberine LipoMicel|DIETARY_SUPPLEMENT: Regular Berberine hard-gels
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Personalized and Interactive Web-based Health Care Innovation to Advance the Quality of Care
Status: COMPLETED
Conditions: Implantable Defibrillator User|Distress
Interventions: OTHER: Supportive care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Co-administered Na-APR-1 (M74) and Na-GST-1 in Gabonese Children
Status: COMPLETED
Conditions: Hookworm Disease|Hookworm Infection
Interventions: BIOLOGICAL: Na-GST-1/Alhydrogel|BIOLOGICAL: Na-APR-1 (M74)/Alhydrogel|BIOLOGICAL: Hepatitis B Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MI With Text Messaging to Reduce Sexual Risk and Hazardous Drinking Among MSM
Status: COMPLETED
Conditions: Alcohol; Harmful Use|Sex, Unsafe
Interventions: BEHAVIORAL: MI&TXT4MSM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Analysis of Olaparib Response in Patients With BRCA1 and/or 2 Promoter Methylation Diagnosed of Advanced Breast Cancer
Status: COMPLETED
Conditions: Advanced Breast Cancer
Interventions: DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Idalopirdine in Patients With Mild - Moderate Alzheimer's Disease Treated With Donepezil
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Placebo|DRUG: Idalopirdine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intravenous Dynastat on Postoperative Sore Throat
Status: UNKNOWN
Conditions: Sore Throat|Postoperative Complications
Interventions: DRUG: Parecoxib Injectable Product|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide|DRUG: Placebo (semaglutide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Larotrectinib in Treating Patients With Previously Untreated TRK Fusion Solid Tumors and TRK Fusion Relapsed Acute Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Central Nervous System Neoplasm|Infantile Fibrosarcoma|Recurrent Acute Leukemia|Refractory Acute Leukemia|Solid Neoplasm
Interventions: DRUG: Larotrectinib Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BENDITA BEnznidazole New Doses Improved Treatment and Associations
Status: UNKNOWN
Conditions: Chagas Disease
Interventions: DRUG: Benznidazole|DRUG: E1224|DRUG: E1224 Placebo|DRUG: Benznidazole Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Romiplostim in Increasing Low Platelet Counts in Patients With Multiple Myeloma Receiving Chemotherapy
Status: TERMINATED
Conditions: Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma|Thrombocytopenia
Interventions: BIOLOGICAL: romiplostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cardiopulmonary Bypass Prime Solution in Patients Undergoing Heart Valve Surgery
Status: COMPLETED
Conditions: Heart Valve Diseases
Interventions: DRUG: Six percent hydroxy ethyl starch 130/0.4|DRUG: Ringer lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluate the Efficacy and Safety of ADCV01 as an Add-On Treatment for Primary Glioblastoma Multiforme (GBM) Patients
Status: UNKNOWN
Conditions: GBM
Interventions: BIOLOGICAL: autologous dendritic cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Utility of Sputum Induction and Novel Technologies to Improve TB Diagnosis in a High HIV Prevalence Primary Care Setting
Status: COMPLETED
Conditions: Tuberculosis
Interventions: PROCEDURE: Sputum induction|PROCEDURE: standard routine expectorated sputum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Hypersensitivity to PACAP-38 in Post-Traumatic Headache
Status: UNKNOWN
Conditions: Post-Traumatic Headache
Interventions: DRUG: Pituitary adenylate cyclase activating polypeptide-38|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect Of Hepatic Impairment on the Pharmacokinetics, Safety and Tolerability of PF-06865571 In Subjects With Hepatic Impairment and in Healthy Subjects
Status: COMPLETED
Conditions: Hepatic Impairment|Healthy Volunteers
Interventions: DRUG: PF-06865571 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Telmisartan Compared With Enalapril in Elderly Patients With Blood Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan|DRUG: Enalapril|DRUG: Clonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bendamustine, Prednisone and Velcade® for First-line Treatment of Patients With Symptomatic Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Bendamustine, Bortezomib, Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Recurrence Prediction of by Texture Analysis Derived From Positron Emission Tomography (PET / CT) Imaging of Non-small Cell Lung Cancer (NSCLC) Treated With Stereotactic Radiotherapy (SBRT) (Retros MUMOFRAT)
Status: COMPLETED
Conditions: Identify FDG PET/CT Parameters Predictive of Local Control
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of TIVA Versus Inhalational Anaesthesia on Circulating Tumour Cells in Hepatocellular Carcinoma Patients
Status: RECRUITING
Conditions: Circulating Tumor Cell|Hepatocellular Carcinoma
Interventions: DRUG: Propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: 11C Topotecan PET Imaging
Status: TERMINATED
Conditions: Lung Cancer|Metastatic Cancer|Ovarian Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: PROCEDURE: computed tomography|PROCEDURE: positron emission tomography|RADIATION: 11C topotecan|RADIATION: fludeoxyglucose F 18
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Efficacy and Safety of AD-208
Status: COMPLETED
Conditions: Androgenetic Alopecia
Interventions: DRUG: AD-208|DRUG: AD-2081|DRUG: placebo of AD-208|DRUG: placebo of AD-2081
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Ultrasound Guided Needle Placement Versus Nerve Stimulation for Coracoid Infraclavicular Brachial Plexus Block
Status: COMPLETED
Conditions: Patients Undergoing Hand Surgery
Interventions: PROCEDURE: Ultrasound compared to dual-endpoint nerve stimulator guided approach.|PROCEDURE: Ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Onvansertib for the Treatment of Recurrent or Refractory Chronic Myelomonocytic Leukemia
Status: RECRUITING
Conditions: Recurrent Chronic Myelomonocytic Leukemia|Refractory Chronic Myelomonocytic Leukemia
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration and Biopsy|DRUG: Onvansertib|PROCEDURE: Ultrasound Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial of Lenient Versus Strict Arm Instruction Post Cardiac Device Surgery
Status: RECRUITING
Conditions: Post-Op Complication
Interventions: BEHAVIORAL: Lenient Arm Restriction|BEHAVIORAL: Strict Arm Restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: How Microbes and Metabolism May Predict Skin Cancer Immunotherapy Outcomes
Status: TERMINATED
Conditions: Autoimmunity|Melanoma|Merkel Cell Carcinoma|Squamous Cell Carcinoma of the Skin|Basal Cell Carcinoma|Skin Cancer
Interventions: BIOLOGICAL: Immunotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p