pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Sugammadex Versus Usual Care on Incidence of Residual Blockade at Post Anesthesia Care Unit Admission (P07981)
Status: COMPLETED
Conditions: Surgical Procedures, Elective
Interventions: DRUG: Sugammadex|DRUG: Neostigmine|DRUG: Glycopyrrolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Swimming Training Repercussion on Metabolic and Structural Bone Development; Benefits of the Incorporation of Whole Body Vibration or Plyometric Training: The RENACIMIENTO Project
Status: UNKNOWN
Conditions: Body Composition
Interventions: DEVICE: Whole-body vibration (Powerplate®)|BEHAVIORAL: Jumping intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of the Effect of Fructans on Fermentation in the Colon & Transit
Status: COMPLETED
Conditions: Evidence of Adaptation to Dietary Exposure to Fructans
Interventions: DIETARY_SUPPLEMENT: Inulin challenge|DIETARY_SUPPLEMENT: oligofructose supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study To Assess The Safety Of PF-06342674 In Adults With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Placebo|BIOLOGICAL: PF-06342674 Dose A|BIOLOGICAL: PF-06342674 Dose B|BIOLOGICAL: PF-06342674 Dose C|BIOLOGICAL: PF-06342674 Dose D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A 3 Arm Randomized Study on Health-related QoL of Elderly Patients With Advanced Soft Tissue Sarcoma
Status: TERMINATED
Conditions: Advanced Soft-tissue Sarcoma
Interventions: DRUG: Doxorubicin|DRUG: Doxorubicin|DRUG: Cyclophosphamide Oral Product|DRUG: Prednisolone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electro-acupuncture for Gait and Balance in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: PROCEDURE: Electroacupuncture|OTHER: Body-worn sensor technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients With a Large Infarct Core
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Best medical management|PROCEDURE: Endovascular therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BCX7353 in Healthy Western and Japanese Volunteers
Status: COMPLETED
Conditions: Hereditary Angioedema
Interventions: DRUG: BCX7353|DRUG: Placebo to match BCX7353
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Rifampicin on the Pharmacokinetics of Intracellular Tenofovir-diphosphate and Tenofovir When Coadministered With Tenofovir Alafenamide Fumarate During the Maintenance Phase of Tuberculosis Treatment in TB/HIV-1 Coinfected Participants
Status: COMPLETED
Conditions: HIV-1-infection|Tuberculosis
Interventions: DRUG: Phase 1: Tenofovir disoproxil fumarate/Emtricitabine/Efavirenz coadministered with Rifampicin/Isoniazid|DRUG: Phase 2: Tenofovir alafenamide/Lamivudine/Efavirenz coadministered with Rifampicin/Isoniazid|DRUG: Phase 3: Tenofovir disoproxil fumarate/Emtricitabine/Efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Two Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Metal-on-Metal Bearing in Primary Total Hip Replacement
Status: TERMINATED
Conditions: Rheumatoid Arthritis|Osteoarthritis|Post-traumatic Arthritis|Collagen Disorders|Avascular Necrosis|Traumatic Femoral Fractures|Nonunion of Femoral Fractures|Congenital Hip Dysplasia|Slipped Capital Femoral Epiphysis
Interventions: DEVICE: Pinnacle Acetabular Cup System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Bimatoprost Timolol Ophthalmic Solution in Patients With Open Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-angle Glaucoma|Ocular Hypertension
Interventions: DRUG: 0.03% Bimatoprost/0.5% Timolol Ophthalmic Solution|DRUG: 0.03% Bimatoprost Ophthalmic Solution and 0.5% Timolol Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acmella Oleracea in the Analgesia of the Digital Rectal Examination
Status: COMPLETED
Conditions: Analgesia in the Digital Rectal Examination
Interventions: BIOLOGICAL: Acmella oleracea gel|DRUG: Lidocaine 2 % Topical Cream|OTHER: Ultrasound gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients
Status: COMPLETED
Conditions: Cleft Lip and Palate
Interventions: PROCEDURE: maxillary alveolar graft by tissue engineering|PROCEDURE: Bone tissue engineering using mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of BF-200 ALA (Ameluz®) and BF-RhodoLED® in the Treatment of Moderate to Severe Acne Vulgaris With Photodynamic Therapy in Adults
Status: RECRUITING
Conditions: Acne Vulgaris
Interventions: COMBINATION_PRODUCT: 1h Incubation Photodynamic therapy (PDT) (ALA-PDT, Ameluz®-PDT)|COMBINATION_PRODUCT: 1h Incubation Photodynamic therapy (PDT) (vehicle to BF-200 ALA containing no active ingredient)|COMBINATION_PRODUCT: 3h Incubation Photodynamic therapy (PDT) (ALA-PDT, Ameluz®-PDT)|COMBINATION_PRODUCT: 3h Incubation Photodynamic therapy (PDT) (vehicle to BF-200 ALA containing no active ingredient)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coronary Plaque Geometry and Acute Coronary Syndromes
Status: COMPLETED
Conditions: Coronary Stenosis|Acute Coronary Syndrome|Acute Myocardial Infarction|Atherosclerosis|Atheromatous Plaques
Interventions: DIAGNOSTIC_TEST: CCTA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Open Label, Proof of Concept Study to Evaluate the Effects of Dalfampridine Withdrawal on Gait and Balance Parameters in Subjects With Multiple Sclerosis (MS)
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: OTHER: Withdrawal of dalfampridine-ER 10mg
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: eMOMS of Rochester
Status: COMPLETED
Conditions: Gestational Weight Gain|Postpartum Weight Retention
Interventions: BEHAVIORAL: electronic intervention during pregnancy and postpartum|BEHAVIORAL: electronic intervention during pregnancy|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fasting Study of Midodrine HCl Tablets 5 mg and ProAmatine® Tablets 5 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Midodrine HCl Tablets 5 mg|DRUG: ProAmatine® Tablets 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate Administration of SBT101 Gene Therapy in Adult Patients With Adrenomyeloneuropathy (AMN)
Status: RECRUITING
Conditions: AMN|AMN Gene Mutation|X-ALD
Interventions: GENETIC: SBT101|PROCEDURE: Imitation Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Predictors of Infective Endocarditis Among Patients Managed for Staphylococcus Aureus Bacteremia, Particularly Staphylococcus Aureus Bacteriuria, and Time to Blood Culture Positivity
Status: ACTIVE_NOT_RECRUITING
Conditions: Bacteremia|Endocarditis, Bacterial
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial Investigating the Mechanism of Action of NNC0109-0012 (Anti-IL-20 mAb) Through Synovial Biopsies in Subjects With Rheumatoid Arthritis and an Inadequate Response to Methotrexate
Status: WITHDRAWN
Conditions: Inflammation|Rheumatoid Arthritis
Interventions: DRUG: NNC0109-0012|DRUG: Adalimumab|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Volatile Anesthetic Choice and Duration of Hospitalization: A Quality Improvement and Cost-control Project
Status: COMPLETED
Conditions: Duration of Hospitalization
Interventions: DRUG: Isoflurane|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Open-label Extension Study of Efficacy, Safety and Tolerability of Secukinumab in Patients With Active Lupus Nephritis
Status: TERMINATED
Conditions: Lupus Nephritis
Interventions: DRUG: Secukinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: What is the Influence of a Different Thread Pitch Design on Bone Remodelling Around Conical Southern Oral Implants?
Status: COMPLETED
Conditions: Dental Implants
Interventions: DEVICE: 0.6 mm tread pitch implant|DEVICE: 0.1 mm tread pitch implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Deep and Moderate Neuromuscular Blockade on Optic Nerve Sheath Diameter
Status: UNKNOWN
Conditions: Intracranial Hypertension
Interventions: DIAGNOSTIC_TEST: Ultrasonographic measurement of optic nerve sheath diameter|PROCEDURE: Deep neuromuscular block|PROCEDURE: Moderate neuromuscular block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Exemestane in Combination With Fulvestrant in Postmenopausal Women With Hormone Sensitive Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Exemestane|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effectiveness of 2 Manual Therapies on Functional Outcome in Sub-acute and Chronic Non-specific Low Back Pain
Status: COMPLETED
Conditions: Subacute and Chronic Non-specific Low Back Pain
Interventions: OTHER: Osteopathic manipulative treatment|OTHER: Placebo of osteopathic manipulative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Administration of Prazosin to Prevent PTSD in Adult Women After Sexual Assault
Status: UNKNOWN
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: Prazosin|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of a Plyometric Training Program on Youths With Different Biological Maturity in Sport
Status: RECRUITING
Conditions: Athletic Performance|Muscle Fatigue|Plyometric Exercise
Interventions: OTHER: Plyometric training|OTHER: Control training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immunomodulation, IL-1 Inhibition, and Postoperative Incisional Pain
Status: TERMINATED
Conditions: Pain|Inflammation
Interventions: DRUG: Anakinra|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Usefulness of Virtual Ablation Guided Catheter Ablation of Atrial Fibrillation: Prospective Randomized Study
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Virtual ablation in based 3D CT of patient who diagnosed AF|PROCEDURE: conventional ablation based on physician's personal experience
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Neurofibromatosis and Progressive Plexiform Neurofibromas
Status: COMPLETED
Conditions: Neurofibromatosis Type 1|Precancerous Condition
Interventions: DRUG: Methotrexate|DRUG: Vinblastine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Gene Delivery Study to Evaluate the Safety and Expression of Delandistrogene Moxeparvovec in Participants Under the Age of Four With Duchenne Muscular Dystrophy (DMD)
Status: RECRUITING
Conditions: Duchenne Muscular Dystrophy
Interventions: GENETIC: delandistrogene moxeparvovec
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aortic Cross-Clamping and Systemic Inflammatory Response in Humans: Effect of Ischemic Preconditioning
Status: COMPLETED
Conditions: Aortic Aneurysm
Interventions: PROCEDURE: Remote ischemic preconditioning|BIOLOGICAL: Blood drawn
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Lactobacillus Reuteri DSM17938 in Neonates Treated With Antibiotics
Status: COMPLETED
Conditions: Gastrointestinal Diseases|Colic
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri DSM 17938|DIETARY_SUPPLEMENT: Placebo|DRUG: ampicillin and gentamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Pivotal Study of rhBMP-2/ACS/INTER FIX™ Device for Posterior Lumbar Interbody Fusion in Patients With Degenerative Disc Disease
Status: TERMINATED
Conditions: Degenerative Disc Disease
Interventions: DEVICE: rhBMP-2/ACS/INTER FIX™|DEVICE: Autogenous bone/INTER FIX™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ASTX727 vs IV Decitabine in Participants With MDS, CMML, and AML
Status: COMPLETED
Conditions: Myelodysplastic Syndromes|Chronic Myelomonocytic Leukemia|Acute Myeloid Leukemia
Interventions: DRUG: ASTX727|DRUG: Dacogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Music on Burden of Dental Implant Surgery
Status: COMPLETED
Conditions: Personalized Musical Intervention
Interventions: OTHER: Personalized music|OTHER: Audio Books
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Human Intracranial Electrophysiology
Status: RECRUITING
Conditions: Epilepsy
Interventions: OTHER: Memory Tasks|OTHER: Attention/arousal tasks|OTHER: Language tasks|OTHER: Visuospatial tasks|OTHER: Auditory Tasks|PROCEDURE: Brain Stimulation|OTHER: Social Emotional Task|OTHER: Recording of facial expressions|OTHER: Judgement/Impulsivity Task
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Terlipressin in the Prevention of Type 2 Hepatorenal Syndrome by Improving Mean Arterial Pressure
Status: UNKNOWN
Conditions: Hepatorenal Syndrome
Interventions: DRUG: Terlipressin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Guided Imagery on Chemotherapy-related Nausea and Vomiting
Status: RECRUITING
Conditions: Chemotherapy-induced Nausea and Vomiting|Pediatric Cancer
Interventions: OTHER: guided imagery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of AEYE Diagnostic Screening (AEYE-DS) Software Device for Detection of Diabetic Retinopathy From Digital Funduscopic Images
Status: RECRUITING
Conditions: Diabetic Retinopathy, DR|Diabetic Mellitus
Interventions: DEVICE: AEYE-DS Software
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Using an API to Commercialize an Evidence-Based Weight Loss Intervention
Status: COMPLETED
Conditions: Weight Loss|Health Behavior
Interventions: BEHAVIORAL: API App|BEHAVIORAL: Non-API App|BEHAVIORAL: fitness tracker|BEHAVIORAL: scale
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Double-Blind Study of E5555 in Japanese Patients With Acute Coronary Syndrome
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: E5555|DRUG: E5555|DRUG: E5555|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Reactogenicity of FluBlok and Comparison of Immunogenicity, Efficacy and Effectiveness Against TIV
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: FluBlok Influenza Vaccination|BIOLOGICAL: TIV (Fluzone) Influenza Vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Gliadel Wafers and Temodar in the Treatment of Glioblastoma Multiforme
Status: TERMINATED
Conditions: Primary Glioblastoma Multiforme
Interventions: OTHER: Gliadel Wafer, Temodar and Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dopamine Transporter Density Profiles in Patients With Periodic Limb Movements
Status: COMPLETED
Conditions: Periodic Limb Movements in Sleep
Interventions: BEHAVIORAL: Aerobic Physical Exercise|BEHAVIORAL: Aerobic Physical Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Drug Levels, Metabolism, and Removal of BMS-986322 in Healthy Adult Male Participants
Status: COMPLETED
Conditions: Healthy Male Participants
Interventions: DRUG: BMS-986322
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Auricular Acupuncture for Exam Anxiety in Medical Students
Status: COMPLETED
Conditions: Anxiety
Interventions: DEVICE: Auricular acupuncture|DEVICE: Placebo acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Dasatinib in Patients With Advanced Cancers Harboring DDR2 Mutation or Inactivating B-RAF Mutation
Status: TERMINATED
Conditions: Carcinoma, Non-small Cell Lung
Interventions: DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IIT-2022-Simultaneous Urolift™ and Median Lobe Enucleation
Status: RECRUITING
Conditions: Benign Prostatic Hyperplasia
Interventions: OTHER: UroLift™ System and Holmium Laser Enucleation of the Prostate (HoLEP)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study With Isentress (Raltegravir) and Epzicom (Abacavir/Lamivudine) in Treatment Naive HIV-Infected Subjects
Status: UNKNOWN
Conditions: HIV Infections
Interventions: DRUG: Raltegravir and Abacavir/Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Protein Diet and Atherosclerosis
Status: RECRUITING
Conditions: Atherosclerosis
Interventions: OTHER: Standard meal|OTHER: High animal protein meal|OTHER: High plant protein meal|OTHER: High plant protein meal with additional leucine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Functional Assessment Screening Patient Reported Information
Status: COMPLETED
Conditions: Quality of Life|Tobacco Use Cessation|Physical Activity
Interventions: OTHER: Will use HIT patient feedback to activate patients.|OTHER: Patients will not receive HIT patient feedback.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: 18F-FDG and 68Ga-FAPI PET/CT in Lung Adenocarcinoma
Status: UNKNOWN
Conditions: Lung Adenocarcinoma|18F-FDG|68Ga-FAPI|PET/CT
Interventions: DIAGNOSTIC_TEST: 68Ga-FAPI PET/CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dose Finding Study of L19TNF and Doxorubicin in Patients With STS
Status: ACTIVE_NOT_RECRUITING
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: L19TNF|DRUG: DOXORUBICIN
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BEtter Control of Blood Pressure in Hypertensive pAtients Monitored Using the HOTMAN® sYstem
Status: COMPLETED
Conditions: Hypertension
Interventions: DEVICE: Integrated hemodynamic management (IHM) - HOTMAN System|DEVICE: Non Integrated Hemodynamic Management (Non-IHM) - HOTMAN System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of a Novel Wearable Compression Technology in the Treatment of Lymphedema, An Open-Label Controlled Study
Status: COMPLETED
Conditions: Breast Cancer Related Lymphedema|Lymphedema of Upper Arm|Lymphedema|Quality of Life
Interventions: DEVICE: User of Dayspring device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dose-dependent Platelet Rich Fibrin(PRF)
Status: COMPLETED
Conditions: Gingival Recession
Interventions: DEVICE: PC-02 Centrifuge device,2PRF+CAF|DEVICE: PC-02 Centrifuge device, 4 PRF+CAF|PROCEDURE: CTG+CAF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Montelukast Sodium (Singulair) in Older Adults With Asthma or Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Asthma|COPD
Interventions: DRUG: montelukast sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Acute Effects of Exercise and Caffeine on Working Memory During Acute Caffeine Deprivation
Status: COMPLETED
Conditions: Acute Exercise|Caffeine Withdrawal|Memory Deficits
Interventions: BEHAVIORAL: Acute Exercise|DRUG: Caffeine Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tear Film Break-Up Time Evaluation of FID 114657
Status: COMPLETED
Conditions: Dry Eye
Interventions: OTHER: FID114657|OTHER: SootheXP Emollient (Lubricant) Eye Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Preliminary Efficacy and PK of Isatuximab (SAR650984) Alone or in Combination With Atezolizumab in Patients With Advanced Malignancies
Status: TERMINATED
Conditions: Neoplasm
Interventions: DRUG: Isatuximab SAR650984|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Timing of Initiation of Luteal Phase Support in Poor Responders Undergoing IVF/ICSI
Status: UNKNOWN
Conditions: Infertility
Interventions: DRUG: Prontogest 400 mg vaginal pessaries
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Trial of Trametinib and Erlotinib in Patients With EGFR-Mutant Lung Adenocarcinomas and Acquired Resistance to Erlotinib
Status: COMPLETED
Conditions: Lung Adenocarcinoma|Lung Cancer|Lung Cancer Metastatic|Lung Cancer Stage IV|Recurrent Lung Adenocarcinoma|Recurrent Lung Cancer
Interventions: DRUG: Trametinib|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Major Memory 2: A Long-term Group Cognitive Stimulation Program
Status: SUSPENDED
Conditions: Neurocognitive Disorders|Dementia|Cognitive Impairment|Cognitive Decline
Interventions: BEHAVIORAL: Cognitive Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: I125 Seed Implantation vs Stereotactic Radiotherapy for Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer Non-resectable|Brachytherapy|Radiotherapy
Interventions: RADIATION: Stereotactic Radiotherapy|RADIATION: 3D-printing Template-assisted CT-guided I125 Seed Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Corticosteroids and Myocardial Injury in CAP (COLOSSEUM TRIAL)
Status: UNKNOWN
Conditions: Community-acquired Pneumonia
Interventions: DRUG: Methylprednisolone Sodium Succinate|DRUG: Saline Solution for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Circulating Tumor DNA Enriched, Genomically Directed Post-neoadjuvant Trial for Patients With Residual Triple Negative Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Triple Negative Breast Cancer
Interventions: DRUG: Capecitabine|DRUG: Talazoparib|DRUG: Pembrolizumab|DRUG: Inavolisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Restrictive Versus Liberal Thresholds for RBC Transfusion in ECMO
Status: NOT_YET_RECRUITING
Conditions: Transfusion|Red Blood Cell|Extracorporeal Membrane Oxygenation|Anemia|ECMO
Interventions: OTHER: Red Blood Cell transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Peripapillary Blood Flow After Use of Anti-glaucoma Medications: An OCT Angiography Study
Status: COMPLETED
Conditions: Glaucoma; Drugs|Normal Tension Glaucoma|Primary Open-angle Glaucoma
Interventions: DRUG: Timolol Maleate|DRUG: Brimonidine Tartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of B. Bifidum 900791 Intake on Breast Milk Characteristics of Obese Mothers
Status: UNKNOWN
Conditions: Maternal Obesity
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cognitive Behavioural Analysis System of Psychotherapy (CBASp) Versus Escitalopram in Chronic Depression
Status: UNKNOWN
Conditions: Chronic Depression
Interventions: OTHER: CBASP psychotherapy|DRUG: Escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breast Reconstruction With Autologous Tissue: Microsurgery or Fat Grafting?
Status: COMPLETED
Conditions: Breast Cancer|Mammaplasty
Interventions: PROCEDURE: Brava-group|PROCEDURE: DIEP-group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Safety, Tolerability, and PK of EDG-5506 in Healthy Volunteers and Becker Muscular Dystrophy Adults
Status: COMPLETED
Conditions: Healthy Volunteer|Becker Muscular Dystrophy
Interventions: DRUG: EDG-5506|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-Guided Erector Spinae Plan Block for Colorectal Surgery
Status: UNKNOWN
Conditions: Colorectal Cancer|Postoperative Pain
Interventions: DRUG: Bupivacaine Hcl 0.25% ESP block|DRUG: Bupivacaine Hcl 0.25% infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Surgical Approach to Endoscopic Pituitary Adenoma Resection
Status: COMPLETED
Conditions: Pituitary Adenoma|Posterior Septectomy|Stamm Approach|Quality of Life
Interventions: PROCEDURE: Stamm Approach|PROCEDURE: Posterior Septectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Modulation of Sleep Perception Through Auditory Closed-loop Stimulation of Brain Oscillatory Activity
Status: COMPLETED
Conditions: Sleep|Insomnia
Interventions: DEVICE: Auditory closed-loop stimulation: slow oscillation boosting|DEVICE: Auditory closed-loop stimulation: slow oscillation disruption|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Ferinject® on Anemia and Transfusion Rates After Cardiac Surgery
Status: COMPLETED
Conditions: Anemia, Iron Deficiency
Interventions: DRUG: Ferric carboxymaltose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of a Dentifrice in Providing Relief From the Pain of Dentinal Hypersensitivity
Status: COMPLETED
Conditions: Dentine Hypersensitivity
Interventions: DRUG: Stannous Fluoride|DRUG: Sodium Monofluorophosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Buccal Mucosal Graft for Onlay Ureteroplasty in the Management of Proximal Ureteral Stricture
Status: RECRUITING
Conditions: Stricture Ureter
Interventions: PROCEDURE: Buccal mucosa for proximal ureter stricture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adherence to Antidepressant Treatment in Subjects With Depression
Status: TERMINATED
Conditions: Depression
Interventions: DRUG: Escitalopram + RT2CK17|DRUG: Escitalopram + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Dry Eye Study With Cosopt® Over 8 Weeks in Patients With Open-Angle Glaucoma or Ocular Hypertension (0507A-152)(COMPLETED)
Status: COMPLETED
Conditions: Ocular Hypertension|Open Angle Glaucoma
Interventions: DRUG: dorzolamide hydrochloride (+) timolol maleate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Granisetron, Aprepitant, and Dexamethasone in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy for Stage II, III, or IV Ovarian Cancer
Status: TERMINATED
Conditions: Nausea and Vomiting|Ovarian Brenner Tumor|Ovarian Clear Cell Cystadenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian Mucinous Cystadenocarcinoma|Ovarian Seromucinous Carcinoma|Ovarian Serous Cystadenocarcinoma|Stage II Ovarian Cancer|Stage IIA Fallopian Tube Cancer|Stage IIA Ovarian Cancer|Stage IIB Fallopian Tube Cancer|Stage IIB Ovarian Cancer|Stage IIC Fallopian Tube Cancer|Stage IIC Ovarian Cancer|Stage IIIA Fallopian Tube Cancer|Stage IIIA Ovarian Cancer|Stage IIIA Primary Peritoneal Cancer|Stage IIIB Fallopian Tube Cancer|Stage IIIB Ovarian Cancer|Stage IIIB Primary Peritoneal Cancer|Stage IIIC Fallopian Tube Cancer|Stage IIIC Ovarian Cancer|Stage IIIC Primary Peritoneal Cancer|Stage IV Fallopian Tube Cancer|Stage IV Ovarian Cancer|Stage IV Primary Peritoneal Cancer|Undifferentiated Ovarian Carcinoma
Interventions: PROCEDURE: Adjuvant Therapy|DRUG: Aprepitant|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Dexamethasone|DRUG: Granisetron Transdermal Patch|PROCEDURE: Management of Therapy Complications|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Pilot Study of a Thrombopoietin-Receptor Agonist, Eltrombopag, in Patients With Low to Int-2 Risk Myelodysplastic Syndrome (MDS)
Status: COMPLETED
Conditions: Myelodysplastic Syndromes|Thrombocytopenia
Interventions: DRUG: Eltrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Letrozole With or Without Paclitaxel and Carboplatin in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Status: RECRUITING
Conditions: Low Grade Fallopian Tube Serous Adenocarcinoma|Ovarian Low Grade Serous Adenocarcinoma|Primary Peritoneal Low Grade Serous Adenocarcinoma|Stage II Fallopian Tube Cancer AJCC v8|Stage II Ovarian Cancer AJCC v8|Stage II Primary Peritoneal Cancer AJCC v8|Stage III Fallopian Tube Cancer AJCC v8|Stage III Ovarian Cancer AJCC v8|Stage III Primary Peritoneal Cancer AJCC v8|Stage IV Fallopian Tube Cancer AJCC v8|Stage IV Ovarian Cancer AJCC v8|Stage IV Primary Peritoneal Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Carboplatin|PROCEDURE: Imaging Technique|DRUG: Letrozole|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Gene Therapy for Painful Diabetic Neuropathy
Status: COMPLETED
Conditions: Painful Diabetic Neuropathy|Diabetic Neuropathy, Painful
Interventions: BIOLOGICAL: Engensis (VM202)|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Phosphatidic Acid on Strength and Hypertrophy
Status: UNKNOWN
Conditions: Hypertrophy|Muscle Strength
Interventions: DIETARY_SUPPLEMENT: phosphatidic acid supplementation|OTHER: Placebo (corn starch supplementation)|OTHER: Strength training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized-controlled Trial of a Combined vs. Conventional Percutaneous Intervention for Near-Infrared Spectroscopy Defined High-Risk Native Coronary Artery Lesions
Status: TERMINATED
Conditions: Arteriosclerosis|Near-infrared Spectroscopy|Peri-procedural Myocardial Infarction|Coronary Artery Disease
Interventions: PROCEDURE: Combined Intervention|PROCEDURE: Conventional PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of 4 Weeks Supplementation of a Combination of Vitamin Bs and Taurine on Mental Performance in Healthy Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Capsules with B vitamins & taurine|OTHER: Microcrystalline cellulose placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed, Non-metastatic Desmoplastic Medulloblastoma
Status: COMPLETED
Conditions: Desmoplastic/Nodular Medulloblastoma|Medulloblastoma|Medulloblastoma With Extensive Nodularity|Nevoid Basal Cell Carcinoma Syndrome
Interventions: DRUG: Carboplatin|OTHER: Cognitive Assessment|DRUG: Cyclophosphamide|DRUG: Etoposide|OTHER: Laboratory Biomarker Analysis|DRUG: Methotrexate|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Jobelyn in the Treatment of Breast Cancer Patients
Status: UNKNOWN
Conditions: Haematological Abnormality
Interventions: DIETARY_SUPPLEMENT: Jobelyn + Cyclophosphamide-Epirubicin6|DRUG: Placebo + Cyclophosphamide - Epirubicin 6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Evaluating the Efficacy of Systemic Mesenchymal Stromal Cell (MSC) Injections for the Treatment of Severe and Chronic Radiotherapy-induced Abdomino-pelvic Complications (Pelvic Radiation Disease, PRD) Refractory to Standard Therapy
Status: UNKNOWN
Conditions: Pelvic Radiation Therapy|Radiation-induced Hemorrhagic Cystitis
Interventions: DRUG: Mesenchymal Stromal Cell (MSC) injections
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Stage IIB, Stage III, or Stage IV Cancer of the Nasopharynx
Status: UNKNOWN
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: cisplatin|DRUG: docetaxel|DRUG: fluorouracil|DRUG: leucovorin calcium|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Microablative Radiofrequency in the Treatment of Urinary Symptoms Associated With Genitourinary Syndrome of Menopause
Status: NOT_YET_RECRUITING
Conditions: Menopause|Urinary Incontinence
Interventions: OTHER: Pelvic floor muscle training|DEVICE: Microablative Radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed Plus Gemcitabine for Patients With Locally Advanced or Metastatic NSCLC Who Have Not Had Previous Chemotherapy.
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: pemetrexed|DRUG: gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Electrical Stimulation and Septic Shock
Status: SUSPENDED
Conditions: Shock, Septic
Interventions: DEVICE: Neuromuscular Electrical Stimulation|OTHER: Decubitus Position with the limbs raised to 20º
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Desensitization to Peanut in Peanut Allergic Children and Adults Using CPNA Peanut OIT Safety Follow-On Study
Status: COMPLETED
Conditions: Peanut Allergy
Interventions: BIOLOGICAL: AR101 - Peanut protein capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Collect and Assess Tissue Samples From Subjects With Hematologic Malignancy
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Multiple Myeloma|Myelodysplastic Syndromes|Lymphoma|Acute Lymphoblastic Leukemia|Chronic Myelogenous Leukemia|Myeloproliferative Neoplasm
Interventions: OTHER: This is a non-interventional study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Neoadjuvant PD-1 Blockade Plus Chemotherapy for Esophageal Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Esophageal Squamous Cell Carcinoma|Immunotherapy
Interventions: DRUG: camrelizumab|DRUG: Paclitaxel for injection (albumin-bound)|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adagrasib in Combination With TNO155 in Patients With Cancer (KRYSTAL 2)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Cancer|Metastatic Cancer|Malignant Neoplastic Disease
Interventions: DRUG: MRTX849|DRUG: TNO155
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incidence of Sore Throat With Traditional Intubation Blades or Glidescope Blade
Status: COMPLETED
Conditions: Intratracheal Intubation|Laryngoscopes|Postoperative Care|Risk Assessment
Interventions: DEVICE: Macintosh/Miller Laryngoscope|DEVICE: Glidescope Laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: the Effect of Opioid-free General Anesthesia
Status: COMPLETED
Conditions: Gynecologic Disease
Interventions: DRUG: Dexmedetomidine Hydrochloride|DRUG: Lidocaine Hydrochloride|DRUG: Remifentanil Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Postoperative Adjuvant Therapy for Non-clear Renal Cell Carcinoma With High-risk Recurrence Factors
Status: RECRUITING
Conditions: Non-clear Renal Cell Carcinoma
Interventions: DRUG: Toripalimab|DRUG: Axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Quizartinib Pharmacokinetics in Participants With Moderate Hepatic Impairment
Status: COMPLETED
Conditions: Hepatic Impairment|Moderate Impaired Hepatic Function
Interventions: DRUG: Quizartinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Before and After Surgery in Treating Patients With Osteosarcoma
Status: TERMINATED
Conditions: Cardiac Toxicity|Sarcoma
Interventions: BIOLOGICAL: filgrastim|DRUG: cisplatin|DRUG: dexrazoxane hydrochloride|DRUG: doxorubicin hydrochloride|DRUG: leucovorin calcium|DRUG: methotrexate|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Cyclosporin A in a Low Humidity Environment, on the Ocular Surface
Status: TERMINATED
Conditions: Dry Eye
Interventions: DRUG: Cyclosporin 0.05% emulsion|DRUG: Endura, Refresh artificial tears
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Epidermolysis Bullosa Dystrophica by Polyphenon E (Epigallocatechin 3 Gallate)
Status: COMPLETED
Conditions: Epidermolysis Bullosa Dystrophica
Interventions: DRUG: Polyphenon E before Placebo|DRUG: placebo before treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Human Lycopene and Beta-cryptoxanthin Absorption From Citrus Fruit
Status: COMPLETED
Conditions: Bioavailability of Carotenoids
Interventions: OTHER: Pink grapefruit first followed by tangerines two weeks later|OTHER: Tangerines first followed by pink grapefruit two weeks later
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bisoprolol Versus Corticosteroid and Bisoprolol Combination for Prophylaxis Against Atrial Fibrillation After on Pump Coronary Artery Bypass Surgery
Status: COMPLETED
Conditions: Prevention|Atrial Fibrillation|CABG
Interventions: DRUG: Bisoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Nutrition Ingredients on Microbiota Modulation
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: Vitamin B2|DIETARY_SUPPLEMENT: Vitamin C|DIETARY_SUPPLEMENT: Vitamin B2 + C|DIETARY_SUPPLEMENT: Vitamin A|DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Vitamin E|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Open-Label, Long-Term Extension Study to Evaluate the Safety of CB-03-01 Cream, 1% in Participants With Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: CB-03-01 cream, 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT