pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety of CDP6038 in Patients With Rheumatoid Arthritis With an Unsuccessful Response to Anti-Tumor Necrosis Factor (Anti-TNF) Therapy
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: CDP6038|BIOLOGICAL: CDP6038|BIOLOGICAL: CDP6038|BIOLOGICAL: Tocilizumab (Actemra or RoActemra)|BIOLOGICAL: CDP6038|BIOLOGICAL: CDP6038|BIOLOGICAL: CDP6038|OTHER: Placebo sc|OTHER: Placebo sc|OTHER: Placebo iv
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Once-Daily Amikacin Plus Cloxacillin in Febrile Neutropenic Children
Status: COMPLETED
Conditions: Neutropenia|Cancer|Fever
Interventions: DRUG: cloxacillin and amikacin (once or twice daily dosage)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Tolerability of Influenza Vaccine in Patients at Risk for Severe and Complicated Influenza
Status: ACTIVE_NOT_RECRUITING
Conditions: Influenza|Obesity|Pregnancy; Infection|Elderly Infection|Vaccine Reaction|Vaccine Adverse Reaction|Tolerance
Interventions: DRUG: Vaxigrip
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase 1-2 Vatalanib and Gemcitabine in Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Vatalanib|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Music in Preventing Delirium in Elderly Patients With Hip Fracture
Status: NOT_YET_RECRUITING
Conditions: Delirium in Old Age|Hip Fractures
Interventions: PROCEDURE: experimental group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Avutometinib for People With Solid Tumor Cancers
Status: RECRUITING
Conditions: Refractory Cancer|CNS Tumors|CNS Tumor, Adult|CNS Tumor, Childhood|MAP Kinase Family Gene Mutation|NF1|Plexiform Neurofibroma|Low-grade Glioma|Optic Pathway Gliomas|Neuroblastoma|Primary Brain Tumor|Solid Tumor|Solid Tumor, Adult|Solid Carcinoma|Central Nervous System Tumor
Interventions: DRUG: Avutometinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Efficacy and Safety of Probiotics eN-Lac® Capsules of Children With Perennial Allergic Rhinitis
Status: COMPLETED
Conditions: Perennial Allergic Rhinitis|Probiotics|Lactobacillus Paracasei GMNL-32 (eN-Lac®)
Interventions: BIOLOGICAL: eN-Lac®|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Musical Group Intervention for Children in Shelters
Status: ENROLLING_BY_INVITATION
Conditions: Domestic Violence|Child Development|Psychological Distress|Music Therapy|Group Intervention
Interventions: BEHAVIORAL: Music, feelings and relationships - music group for children at shelters
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Oral Probiotics on Neonatal Hyperbilirubinemia
Status: RECRUITING
Conditions: Hyperbilirubinemia, Neonatal
Interventions: OTHER: Lactobacillus salivarius AP-32|OTHER: Bifidobacterium animalis subspecies lactis CP-9|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Budesonide / Formoterol in Treatment of Exacerbations of COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: budesonide/formoterol, 2x 200/6 microgram. 4 times daily|DRUG: prednisolone, 30 mg once daily and placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Novel Serious Game as an Alternative for Teaching Basic Point-of-Care Transthoracic Echocardiography Skills
Status: RECRUITING
Conditions: Echocardiography|Education, Medical
Interventions: OTHER: Simulator for Basic Ultrasound Skills|OTHER: Serious Video Game
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Volume Therapy With Crystalloids and Colloids and Hemodynamic Monitoring in Patients With Severe Sepsis
Status: WITHDRAWN
Conditions: Severe Sepsis
Interventions: DRUG: Volulyte|DRUG: Jonosteril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Deep Brain Stimulation in Patients With Chronic Treatment Resistant Depression
Status: COMPLETED
Conditions: Major Depressive Disorder|Recurrent Depressive Disorder|Bipolar Disorder
Interventions: DEVICE: DBS|DEVICE: SHAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized Nutrition Education in Improving Eating Habits of Healthy Participants Who Eat an Unhealthy Diet
Status: UNKNOWN
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BEHAVIORAL: behavioral dietary intervention|OTHER: educational intervention|OTHER: preventative dietary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Transcranial Direct Current Stimulation in the Treatment of Dyslexia.
Status: COMPLETED
Conditions: Dyslexia
Interventions: DEVICE: Active tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of HMI-103 in Participants With Classical PKU Due to PAH Deficiency
Status: TERMINATED
Conditions: Phenylketonurias|PAH Deficiency|Phenylketonuria
Interventions: DRUG: HMI-103
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Gonadal Hormone Suppression on Adipocyte Lineage and the Microbiome
Status: TERMINATED
Conditions: Adipose Tissue|Microbiome|Menopause
Interventions: OTHER: GnRHag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vorinostat, Carboplatin, and Paclitaxel in Treating Patients With Advanced or Metastatic Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Recurrent Non-small Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: DRUG: vorinostat|DRUG: paclitaxel|DRUG: carboplatin|OTHER: placebo|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Glufosfamide in Patients With Recurrent Sensitive Small Cell Lung Carcinoma
Status: TERMINATED
Conditions: Carcinoma, Small Cell Lung
Interventions: DRUG: Glufosfamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of K-001 in the Treatment of Advanced Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: DRUG: K-001|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pain Sensitization in Rheumatoid Arthritis: Analysis on a Cohort of Tofacitinib Treated Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: OTHER: Clinical examination|OTHER: Pain assessment|OTHER: blood sample|OTHER: Patient Reported Outcomes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Placebo Controlled Safety and Efficacy Study of MSDC-0160 in Type 2 Diabetes With Active Comparator
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Placebo|DRUG: Pioglitazone|DRUG: MSDC-0160 90 mg|DRUG: MSDC-0160 220 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of NeuroBOX and NeuroPAP in Infants.
Status: COMPLETED
Conditions: Pediatric Respiratory Diseases|Bronchiolitis|Infant Respiratory Distress Syndrome
Interventions: DEVICE: NeuroPAP ventilation (2h) and NeuroBox monitoring (23h)|DEVICE: NeuroPAP ventilation (4h) and NeuroBox monitoring (25h)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Biomarker Explanation of IBI-323 + Bevacizumab Plus Platinum Based Chemotherapy on ALK-Rearranged NSCLC
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: IBI-323 combined with bevacizumab plus Platinum
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transdermal Estrogen in Women With Anorexia Nervosa
Status: RECRUITING
Conditions: Anorexia Nervosa
Interventions: DRUG: Transdermal estrogen|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous Amlitelimab Moderate to Severe Atopic Dermatitis Clinical Trials
Status: RECRUITING
Conditions: Dermatitis Atopic
Interventions: DRUG: Amlitelimab|DRUG: Topical corticosteroids|DRUG: Topical calcineurin inhibitors|DRUG: Oral corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Examining Parker-Flex Endotracheal Tube for Obese Patients
Status: COMPLETED
Conditions: Obesity
Interventions: DEVICE: Parker Flex-Tip® tracheal tube|DEVICE: Portex® Tracheal Tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ABI-M201 in Adult Subjects With Mildly-to-Moderately Active Ulcerative Colitis
Status: TERMINATED
Conditions: Ulcerative Colitis Chronic Mild|Ulcerative Colitis Chronic Moderate
Interventions: DRUG: ABI-M201|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Blinatumomab in Adults With Newly Diagnosed High-risk Diffuse Large B-Cell Lymphoma
Status: COMPLETED
Conditions: High-risk Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Blinatumomab|DRUG: Investigator's Choice Chemotherapy|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Food Effect on ONO-5920/YM529 Intermittent Formulation
Status: COMPLETED
Conditions: Osteoporosis|Osteoporosis, Postmenopausal|Bone Diseases
Interventions: DRUG: ONO-5920 / YM529
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Anesthetic Infiltration and Infusion for Pain Control After Hip Replacement
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: PROCEDURE: Ropivacaine infiltration and saline infusion.|PROCEDURE: Ropivacaine infiltration and infusion.|PROCEDURE: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Savolitinib Plus Docetaxel as 2L in EGFR/ALK/ROS1/MET ex14m-wildtype NSCLC With MET Overexpression
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Savolitinib|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Fiber-Reinforced Composites on Quality of Life and Bone Height in Maxillary Implant Arches
Status: NOT_YET_RECRUITING
Conditions: Edentulous Alveolar Ridge
Interventions: PROCEDURE: PROVSIONALIZATION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Efficacy of Transvers Abdominis Plane Block and Transversalis Fascia Plane Block in Cesarean Section
Status: RECRUITING
Conditions: Obstetric
Interventions: PROCEDURE: Transverse Facia Plane Block (TAP Block)|PROCEDURE: Transversalis Facia Plane Block (TFP Block)|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hepatic Mitochondrial Metabolism in Fatty Liver Disease in Humans
Status: ENROLLING_BY_INVITATION
Conditions: Non-alcoholic Fatty Liver Disease NAFLD
Interventions: DIAGNOSTIC_TEST: 13C-α-Ketoisocaproic Acid Breath Test|DIETARY_SUPPLEMENT: Ethanol|DIETARY_SUPPLEMENT: Lipid Emulsion|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effectiveness and Safety of Human Lumbar Puncture Assist Device (LPat)
Status: COMPLETED
Conditions: Meningitis|Encephalitis|Guillain-Barré|Subarachnoid Hemorrhage|Intracranial Neoplasm|Intracranial CNS Disorder
Interventions: DEVICE: LPat Device
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of an Integrated Economic Strengthening and HIV Prevention Program for Vulnerable Youth in South Africa
Status: COMPLETED
Conditions: HIV|HIV Infections
Interventions: BEHAVIORAL: Economic Strengthening (Impumelelo)|BEHAVIORAL: HIV Prevention Education (Vhutshilo 2.2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparative Study of Human Immunodeficiency Virus Negative Host Talaromyces Between Voriconazole and Amphotericin Sequential Itraconazole Therapy
Status: UNKNOWN
Conditions: Talaromyces in Human Immunodeficiency Virus Negative|To Compare Voriconazole and Amphotericin Sequential Itraconazole Therapy|To Dynamically Monitor the Anti-Interferon-γ Autoantibodies
Interventions: DRUG: Voriconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Subcutaneous Nivolumab Versus Intravenous Nivolumab in Participants With Previously Treated Clear Cell Renal Cell Carcinoma That is Advanced or Has Spread
Status: RECRUITING
Conditions: Clear Cell Renal Cell Carcinoma
Interventions: BIOLOGICAL: Nivolumab and rHuPH20|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bone Changes in Atrophic Maxilla Treated by Split-crest Technique
Status: UNKNOWN
Conditions: Atrophy; Edentulous Ridge
Interventions: BIOLOGICAL: Ridge splitting, immediate implant, Nanobone with PRF.|BIOLOGICAL: Ridge splitting, immediate implantand PRF.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Finding of Propranolol in Combination With Metronomic Fixed Oral Cyclophosphamide Based on Bivariate Efficacy-tolerability Outcome in Patients With Locally Advanced or Metastatic Angiosarcoma: A Collaborative and Innovative Phase I-II Sequential Trial by the French Sarcoma Group (GSF/GETO)
Status: UNKNOWN
Conditions: Angiosarcoma
Interventions: DRUG: PROPRANOLOL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxytocin Treatment in Neonates and Infants With Prader-Willi Syndrome
Status: COMPLETED
Conditions: Prader-Willi Syndrome
Interventions: DRUG: OT|DRUG: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CMP-001 in Combination With Pembrolizumab in Subjects With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of Head and Neck
Interventions: DRUG: CMP-001|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Safety Study of Dengusiil in Healthy Adults
Status: COMPLETED
Conditions: Prevention of Dengue Fever
Interventions: BIOLOGICAL: Dengusiil|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Randomized Trial to Compare Busulfan + Melphalan 140 mg/m2 With Melphalan 200 mg/m2 as Preparative Regimen for Autologous Hematopoietic Stem Cell Transplantation for Multiple Myeloma
Status: COMPLETED
Conditions: Myeloma
Interventions: DRUG: Busulfan|DRUG: Melphalan|OTHER: Questionnaire|DRUG: G-CSF|DRUG: High Dose Melphalan|PROCEDURE: Stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermitent Hypoxia and Its Pathophysiology Consequences in the Sleep Apnea-Hypopnea Syndrome.
Status: UNKNOWN
Conditions: Sleep Apnea, Obstructive
Interventions: DEVICE: CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arginine + Citrulline as a Supplement for Weight Gain in Fetus With a Decrease in Their Growth Curve
Status: UNKNOWN
Conditions: Fetal Growth Retardation
Interventions: DIETARY_SUPPLEMENT: L-arginine 3g + L-Citruline 2 g|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Cyclophosphamide, Hydroxydaunorubicin, Oncovin, Prednisone (CHOP) With Ofatumumab in Patients With Richter's Syndrome
Status: COMPLETED
Conditions: Richter's Syndrome
Interventions: DRUG: Ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Melatonin Niosomes Oral Gel in Healthy Volunteers
Status: UNKNOWN
Conditions: Pharmacokinetics of Melatonin
Interventions: DRUG: Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Effect of Oral Cinnamon Intervention in Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Cinnamon|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Using a Motivational Interviewing (MI) Informed Text Messaging Program to Lower Blood Sugar in Diabetic Patients.
Status: COMPLETED
Conditions: Type II Diabetes Mellitus
Interventions: BEHAVIORAL: MI- informed SMS program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Observational Study of Follow-up of Hospitalized Patients Diagnosed With COVID-19 to Evaluate the Effectiveness of the Drug Treatment Used to Treat This Disease. COVID-19 Registry
Status: UNKNOWN
Conditions: SARS-CoV-2
Interventions: DRUG: Patients with the treatment agains COVID19
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Trial Evaluating the Efficacy and Safety of Dasatinib in Refractory Metastatic GIST
Status: UNKNOWN
Conditions: Gastrointestinal Stromal Tumor
Interventions: DRUG: dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Re-irradiation of Local Recurrences of Prostate Cancer After Radiotherapy
Status: RECRUITING
Conditions: Local Recurrence of Malignant Tumor of Prostate|Radiotherapy
Interventions: RADIATION: Stereotactic Body Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicomponent Program for the Integrated Management of Chronic Pain and Depression in Primary Care
Status: UNKNOWN
Conditions: Depressive Disorder|Musculoskeletal Pain|Chronic Pain
Interventions: OTHER: Clinical program for pain and depression|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effect of IW-1701 (Olinciguat), a Stimulator of Soluble Guanylate Cyclase (sGC), on Patients With Sickle Cell Disease (SCD)
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: IW-1701|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Control of Therapy of Acne Papulopustulosa by Visible Light With Waterfiltered Infrared and / or Adapalen (Differin Gel)
Status: UNKNOWN
Conditions: Acne Papulopustulosa
Interventions: DRUG: Adapalen|RADIATION: VIS and wIRA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anastrozole With or Without Gefitinib in Treating Postmenopausal Women With Metastatic or Locally Recurrent Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: anastrozole|DRUG: gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Nivolumab in Combination With Ipilimumab in Chinese Participants With Previously Treated Advanced or Recurrent Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: D-serine for Posttraumatic Stress Disorder Treatment
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: D-serine (~2g /day)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Eldecalcitol and Calcitriol in Postmenopausal Women With Low Bone Mineral Density or Mild Osteoporosis
Status: RECRUITING
Conditions: Low Bone Mineral Density|Postmenopausal Osteoporosis
Interventions: DRUG: Eldecalcitol capsules|DRUG: Calcitriol capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of a Paclitaxel Eluting PTCA Balloon Catheter in Coronary In-stent Restenosis
Status: UNKNOWN
Conditions: Coronary In-stent Restenosis
Interventions: DEVICE: Paclitaxel eluting PTCA balloon|DEVICE: SeQuent® Please paclitaxel eluting balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Metastatic Cancer of an Unknown Site of Origin
Status: UNKNOWN
Conditions: Carcinoma of Unknown Primary
Interventions: DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: epirubicin hydrochloride|DRUG: fluorouracil|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of Ramucirumab (LY3009806) in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ramucirumab - IV|DRUG: Placebo - IV|DRUG: Ramucirumab - SC|DRUG: Placebo - SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of DCVAC/OvCa Plus Standard of Care in Relapsed Platinum Resistant Epithelial Ovarian Carcinoma
Status: TERMINATED
Conditions: Epithelial Ovarian Carcinoma
Interventions: BIOLOGICAL: DCVAC/OvCa|DRUG: Standard of Care (Paclitaxel or topotecan or doxorubicin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in People With Depression to Test the Effects of BI 1358894 on Parts of the Brain That Are Involved in Emotions
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: BI 1358894|DRUG: Placebo matching BI 1358894|DRUG: Citalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment Premature Ejaculation
Status: COMPLETED
Conditions: Premature Ejaculation
Interventions: DRUG: PSD502, contains a mixture of lidocaine and prilocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of BIA 2-093 on the Steady-state Pharmacokinetic Profile of Phenytoin in Patients
Status: TERMINATED
Conditions: Epilepsy
Interventions: DRUG: Eslicarbazepine acetate|DRUG: phenytoin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Total Enteral Feeding Versus Conventional Enteral Feeding in Stable Very Low Birth Weight Infants
Status: COMPLETED
Conditions: Nutrition of Preterm Infants
Interventions: OTHER: Early total enteral feeding (ETEF)|OTHER: Conventional enteral feeding (CEF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Postprandial Fatty Acid Metabolism in Subjects With Lipoprotein Lipase Deficiency
Status: RECRUITING
Conditions: Lipoprotein Lipase Deficiency
Interventions: DRUG: Heparin|DIETARY_SUPPLEMENT: liquid meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Quality of Life After Routine Nasogastric Decompression After Distal Gastrectomy for Gastric Cancer Patients
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DEVICE: nasogastric tube|DEVICE: without nasogastric tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab (MK-3475) as First-line Therapy for Advanced Merkel Cell Carcinoma (MK-3475-913)
Status: COMPLETED
Conditions: Merkel Cell Carcinoma
Interventions: DRUG: Pembrolizumab (MK-3475)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Muscle Energy Techniques and Breathing Exercises for Functional Improvement in Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: OTHER: METs|OTHER: Breathing exercise group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of the CryoCor™ Cardiac Cryoablation System for the Treatment of Atrial Flutter
Status: COMPLETED
Conditions: Atrial Flutter
Interventions: DEVICE: Catheter-based cardiac cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TAS-205 for Duchenne Muscular Dystrophy
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: TAS-205|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 2D Versus 3D Radical Laparoscopic Hysterectomy for Cervical Cancer: a Prospective Randomized Trial
Status: COMPLETED
Conditions: Uterine Cervical Neoplasms|Laparoscopic Surgical Procedures
Interventions: PROCEDURE: 3D Laparoscopy|PROCEDURE: Standard Laparoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Generic Tazarotene Cream, 0.1% in the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Vehicle|DRUG: Tazarotene Cream, 0.1 %|DRUG: Tazorac Cream, 0.1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Pelacarsen (ISIS 681257) in Healthy Japanese Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Placebo|DRUG: Pelacarsen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Tactile Acuity in Experimentally Induced Acute Low Back Pain
Status: COMPLETED
Conditions: Acute Pain|Low Back Pain
Interventions: OTHER: Saline injection|OTHER: Sham injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Glucose and Insulin Responses to Test Foods
Status: COMPLETED
Conditions: Glucose Response|Insulin Response
Interventions: OTHER: Reference Glucose|OTHER: Test Food 1 (Cereal)|OTHER: Test Food 2 (Biscuit)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Suprascapular Nerve Block and Axillary Nerve Block After Arthroscopic Rotator Cuff Repair
Status: RECRUITING
Conditions: Rotator Cuff Tears
Interventions: PROCEDURE: Preemptive ultrasound-guided suprascapular nerve block and axillary nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Genistein Supplementation to Mitigate Cardiometabolic Dysfunction in Patients Undergoing Androgen Deprivation Therapy for Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Genistein|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Karenitecin (BNP1350) in Patients With Brain Tumors
Status: COMPLETED
Conditions: Brain Neoplasms|Malignant Neoplasms, Brain|Brain Tumors
Interventions: DRUG: Karenitecin (BNP1350)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intubation of Obese Patients in the Operating Room With or Without Bag-Mask Ventilation
Status: RECRUITING
Conditions: Morbid Obesity|Ventilation Therapy; Complications
Interventions: PROCEDURE: No ventilation with face mask|PROCEDURE: Ventilation with face mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Anti-CD7 U-CAR-T Cell Therapy for T/NK Cell Hematologic Malignancies
Status: UNKNOWN
Conditions: T-cell Leukemia|T-cell Lymphoma
Interventions: BIOLOGICAL: CD7 UCAR-T cells|DRUG: Fludarabine|DRUG: Cytoxan|DRUG: Melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of eHealth-support on Quality of Life in Metastatic Breast Cancer Patients Treated With Palbociclib and Endocrine Therapy
Status: TERMINATED
Conditions: Breast Neoplasm
Interventions: DRUG: Palbociclib|DRUG: Fulvestrant|DRUG: Anastrozole|DRUG: Letrozole|DRUG: Exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Impact of Changes in Carbonemia on Microcirculation in Patients Achieving a Test Hypercapnia
Status: COMPLETED
Conditions: Microcirculation|Blood Circulation
Interventions: DEVICE: confocal microscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Optimal Dosing of Omeprazole in Neonates
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease (GERD)
Interventions: DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-blind, Placebo-controlled Study to Assess Fatigue in Patients With ACD Due to RA Receiving PROCRIT
Status: TERMINATED
Conditions: Anemia|Rheumatoid Arthritis
Interventions: DRUG: Epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Epidural Injection of Corticosteroids Under USG (EICUS)
Status: WITHDRAWN
Conditions: Pain Management
Interventions: DEVICE: Ultrasound|DEVICE: Radioscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Meropenem Versus Meropenem Plus Glycopeptide in Patients With Febrile Neutropenia After Allogenic Blood Stem Cell Transplantation
Status: COMPLETED
Conditions: Allogenic Blood Stem Cell Transplantation|Febrile Neutropenia
Interventions: DRUG: Meropenem|DRUG: Vancomycin|DRUG: Teicoplanin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cracking the Code of Crying Babies: How Familiarity Changes the Interpretation of Cries
Status: COMPLETED
Conditions: Magnetic Resonance Imaging|Neuronal Activity
Interventions: BEHAVIORAL: inclusion and familiarization|BEHAVIORAL: fMRI acquisition and closure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Oral Idebenone for Preventive Treatment of Migraine in Adult Migraine Patients
Status: UNKNOWN
Conditions: Migraine
Interventions: DRUG: Idebenone+ placebo|DRUG: Idebenone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Improving the Understanding of the Response to Vitamin D Supplementation
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: cholecalciferol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Hybrid Polyetheretherketone (PEEK)-Acrylic Resin Prostheses and the All-on-4 Concept for Full Arch Rehabilitation
Status: COMPLETED
Conditions: Dental Implants|Dental Materials|Mandible|Prosthesis Survival
Interventions: DEVICE: PEEK- acrylic resin prosthesis supported by 4 dental implants
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of 3,4-Diaminopyridine in Lambert-Eaton Myasthenic Syndrome
Status: COMPLETED
Conditions: Lambert-Eaton Myasthenic Syndrome|Eaton-Lambert Myasthenic Syndrome
Interventions: DRUG: Continuous 3,4-DAP|DRUG: Taper 3,4-DAP to Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Bomedemstat in Participants With Essential Thrombocythemia (IMG-7289-CTP-201/MK-3543-003)
Status: COMPLETED
Conditions: Essential Thrombocythemia
Interventions: DRUG: Bomedemstat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Dopamine Versus Vasopressin for Treatment of Low Blood Pressure in Low Birth Weight Infants
Status: COMPLETED
Conditions: Hypotension
Interventions: DRUG: Dopamine|DRUG: Arginine Vasopressin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: WEakness and Atrophy: isoKinetic With Surface Electromyography Assessment in ACL Surgery
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament Injury|Muscle Weakness
Interventions: OTHER: isokinetic assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A.Chohan Continuous Squeezing Suture (ACCSS) for Placenta Previa / Accreta
Status: COMPLETED
Conditions: Placenta Previa With Hemorrhage - Delivered|Placenta Accreta
Interventions: PROCEDURE: ACCSS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Socially Assistive Robots for Interaction With Older Adults With Dementia
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: BEHAVIORAL: Play Serious Games with a Social Robot (Ryan)|BEHAVIORAL: Play Solitary Games Without a Social Robot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 1b/2 Trial of the Safety and Microbiological Activity of Bacteriophage Therapy in Cystic Fibrosis Subjects Colonized With Pseudomonas Aeruginosa
Status: RECRUITING
Conditions: Bacterial Disease Carrier|Cystic Fibrosis
Interventions: OTHER: Placebo|BIOLOGICAL: WRAIR-PAM-CF1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: COMPASS Study: an Online Cognitive-behavioural Therapy (CBT) Program Treating Anxiety and Low Mood in Long-term Conditions During the COVID-19 Pandemic
Status: COMPLETED
Conditions: Treatment of Illness-related Distress in Physical LTCs
Interventions: BEHAVIORAL: COMPASS|BEHAVIORAL: Standard charity resources
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Therapeutic Equivalence and Safety of TRETINOIN CREAM, 0.05% and RLD in the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Tretinoin cream, 0.05%|DRUG: RETIN-A® (tretinoin) cream, 0.05%|DRUG: Vehicle of the test product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Education-Based İntervention Program for Persons With Chronic Obstructive Pulmonary Disease (EBIPCOPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: An Education-Based Intervention Program and handbook (EBIP, hospital and home)|OTHER: PFT, BMI, BDI, SCMP-G
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Nintedanib in Patients With Progressive Fibrosing Interstitial Lung Disease (PF-ILD)
Status: COMPLETED
Conditions: Lung Diseases, Interstitial
Interventions: DRUG: Nintedanib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety of Cotrimoxazole in HIV- and HAART-exposed Infants
Status: COMPLETED
Conditions: Acquired Immunodeficiency Syndrome|Infant, Newborn|Anemia|Neutropenia|HIV Infections
Interventions: DRUG: cotrimoxazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Comparison Between Propofol and Etomidate in Hysteroscopy on Effect of Postoperative Sedation and Cognitive Function in Elderly Patients
Status: UNKNOWN
Conditions: Hysteroscopy|Hemodynamics|Sedation
Interventions: DRUG: Etomidate|DRUG: Propofol|DRUG: Remifentanil|DRUG: Anesthesia induction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Pulmozyme Withdrawal on Exercise Tolerance in Cystic Fibrosis Subjects With Severe Lung Disease (TOPIC)
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DRUG: Dornase alfa|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Of Rocuronium Reversal By Sugammadex To Succinylcholine For Electroconvulsive Therapy (ECT)
Status: COMPLETED
Conditions: Neuromuscular Blockade
Interventions: DRUG: Group A. "Muscle relaxant #1": rocuronium + sugammadex; "Muscle relaxant #2": succinylcholine +saline|DRUG: Group B. "Muscle relaxant #2": succinylcholine +saline; "Muscle relaxant #1": rocuronium + sugammadex;
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Recovering Together: Building Resiliency in Dyads of Patients Admitted to the Neuroscience Intensive Care Unit (NICU) and Their Caregivers
Status: COMPLETED
Conditions: Acute Brain Injuries
Interventions: BEHAVIORAL: Recovering Together
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness Intraarticular Corticosteroid
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Triamcinolone hexacetonide|DRUG: Triamcinolone hexacetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimized Care of People With Diabetes and Foot Complication in Primary Care
Status: RECRUITING
Conditions: Diabetes|Diabetic Foot|Diabetes Mellitus|Diabetes Mellitus, Type 2|Diabetes Mellitus, Type 1|Diabetes Complications
Interventions: OTHER: Patients being foot examined by using an eHealth tool|OTHER: Patients being foot examined in traditional manner
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neo-adjuvant Chemoradiotherapy Using Infusional Gemcitabine Followed by Surgery for Locally Advanced Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Adenocarcinoma
Interventions: DRUG: Gemcitabine|RADIATION: XRT|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supervised Outdoor-Use Test to Assess the Safety of a Sunscreen C-Spray on Sport Users
Status: COMPLETED
Conditions: Sunscreen Agents
Interventions: DRUG: BAY 987519, SPF 50, Y51-002|DRUG: BAY 987519, SPF 50, P04-147
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Melatonin and Ulcerative Colitis: A Pilot Clinical Trial
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: DRUG: Melatonin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Research Study to Look at How Insulin 287 and Semaglutide Work in the Body of People With Type 2 Diabetes When Taken Alone or Together
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: NNC0148-0287sema|DRUG: Semaglutide|DRUG: NNC0148-0287
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Arbaclofen in Children and Adolescents With ASD
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Arbaclofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Food as Medicine: A Quasi-Randomized Control Trial of Healthy Foods for Chronic Disease Management
Status: COMPLETED
Conditions: Obesity|Hypertension|Pre-diabetes|Type 2 Diabetes
Interventions: OTHER: Medically-tailored meals|OTHER: Produce box and recipes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT