pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy Study of Risedronate to Prevent Cancer Treatment-Induced Bone Loss in Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: risedronate|DRUG: risedronate|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Apatinib in Radioactive Iodine-refractory Differentiated Thyroid Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Differentiated Thyroid Cancer
Interventions: DRUG: Apatinib Oral Tablet|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Regulation of Extracellular Sodium in End Stage Renal Disease Upon Volume and Electrolyte Challenges
Status: RECRUITING
Conditions: Hyponatremia
Interventions: OTHER: Water administration|OTHER: NaCl-Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Trabectedin or Dacarbazine for the Treatment of Patients With Advanced Liposarcoma or Leiomyosarcoma
Status: COMPLETED
Conditions: Advanced Liposarcoma or Leiomyosarcoma
Interventions: DRUG: Trabectedin|DRUG: Dacarbazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of PRI-724 Plus Gemcitabine in Subjects With Advanced or Metastatic Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Advanced Pancreatic Cancer|Metastatic Pancreatic Cancer|Pancreatic Adenocarcinoma
Interventions: DRUG: PRI-724
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Thoracic ESPB for Post Mastectomy Pain Control, Comparing 2 Dosing Regimens of Lidocaine With Different Drug Volumes
Status: UNKNOWN
Conditions: Analgesia
Interventions: PROCEDURE: Erector spine plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Trial Protocol: Randomized Placebo-Controlled Pilot Study of GcMAF (Soloways TM) in Patients With Metastatic Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: BIOLOGICAL: GcMAF injections (100 ng)|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Modes of Transcutaneous Electrical Nerve Stimulation (TENS) in Chronic Neuropathic Radiculalgia
Status: COMPLETED
Conditions: Neuropathic Pain|Radiculopathy
Interventions: DEVICE: CEFAR Primo Pro (TENS device)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Intravitreal Anti-VEGF Versus Combination Therapy in Central Retinal Vein Occlusion
Status: COMPLETED
Conditions: Central Retinal Vein Occlusion With Macular Edema
Interventions: DRUG: Group A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Inhaled Cannabis on Driving Performance
Status: COMPLETED
Conditions: Alcohol Drinking|Cannabis
Interventions: DRUG: Alcohol(oral) and placebo|DRUG: Cannabis(THC)(Inhaled) and Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase II Early Behavioral Intervention in BMT w/ Sleep Disturbance-Assess QOL+Fatigue+Cognitive f(x)
Status: COMPLETED
Conditions: Cognition Disorders|Fatigue|Sleep Disorders|Other Complications of Bone Marrow Transplant
Interventions: OTHER: quality-of-life assessment|OTHER: questionnaire administration|BEHAVIORAL: management of therapy complications|BEHAVIORAL: cognitive assessment|BEHAVIORAL: educational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety of Local Dental Anesthesia in Patients With Cardiac Channelopathies
Status: COMPLETED
Conditions: Channelopathies|Brugada Syndrome|Long QT Syndrome|Ventricular, Tachycardia
Interventions: PROCEDURE: Dental restorative procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Triple Therapy in COPD
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Long-acting beta2-agonist-long-acting muscarinic antagonists-inhaled corticosteroids(LABA-LAMA-ICS)|DRUG: Long-acting beta2-agonist-inhaled corticosteroids-long-acting muscarinic antagonists (LABA-LAMA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The ASAP Study - Therapeutic Efficacy of Atovaquone-proguanil vs. Artesunate-atovaquone-proguanil in Cambodia
Status: UNKNOWN
Conditions: Malaria
Interventions: DRUG: atovaquone-proguanil|DRUG: artesunate-atovaquone-proguanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Persistence of Antibodies in Adolescents and Adults 15 to 23 Years Who Received One Dose of Menactra® or Menomune®
Status: COMPLETED
Conditions: Meningitis|Meningococcal Infection
Interventions: BIOLOGICAL: Meningococcal Polysaccharide Diphtheria Toxoid Conjugate|BIOLOGICAL: Meningococcal Polysaccharide Diphtheria Toxoid Conjugate|BIOLOGICAL: Meningococcal Polysaccharide Diphtheria Toxoid Conjugate|BIOLOGICAL: Meningococcal Polysaccharide Diphtheria Toxoid Conjugate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Compare the Frequency of Constipation Symptoms With Tapentadol Immediate Release (IR) Treatment Versus Oxycodone IR Treatment in Patients With End-stage Joint Disease
Status: COMPLETED
Conditions: Joint Diseases|Arthritis|Osteoarthritis
Interventions: DRUG: oxycodone CR|DRUG: oxycodone IR|DRUG: Tapentadol ER (CG5503)|DRUG: Tapentadol IR (CG5503)|DRUG: Tapentadol IR (CG5503)|DRUG: placebo|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Hypercapnia, Supplemental Oxygen, and Dexamethasone on Surgical Wound Infection
Status: COMPLETED
Conditions: Surgical Wound Infection|Surgery, Colon
Interventions: OTHER: Mild intraoperative hypercapnia (50 mmHg vs. 30 mmHg)|OTHER: Supplemental oxygen (80% vs. 30%)|DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Effects of a New Infant Formula Supplemented With a Probiotic Over the Corporal Composition of Infants
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Nutribén Innova® 1|DIETARY_SUPPLEMENT: Nutribén®|DIETARY_SUPPLEMENT: Breastfeed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: UARK 2013-13, Total Therapy 4B - Formerly 2008-01 - A Phase III Trial for Low Risk Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: M-VTD-PACE|DRUG: TT3-LITE Regimen (L-TT3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Clinical Outcome of a Modified d'Hoore Technique for Laparoscopic Ventral Mesh Rectopexy
Status: RECRUITING
Conditions: Rectocele|Enterocele|Rectal Prolapse
Interventions: DEVICE: Ifabond (Péters surgical)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lapatinib With Temozolomide and Regional Radiation Therapy for Patients With Newly-Diagnosed Glioblastoma Multiforme
Status: COMPLETED
Conditions: Newly Diagnosed Glioblastoma Multiforme
Interventions: OTHER: Lapatinib/Temozolomide/radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prognostic Value of Lung Cancer MicroAnatomy in 3D
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer|Adenocarcinoma of Lung|Pathology|Micro-computed Tomography|X-ray Histology|Digital Pathology
Interventions: DEVICE: micro-computed tomography scanning of lung tissue specimens
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hericium Erinaceus Mycelium and Probiotic of the Grape King Bio on Symptoms of Premenstrual Syndrome
Status: UNKNOWN
Conditions: Premenstrual Syndrome
Interventions: DIETARY_SUPPLEMENT: Hericium Erinaceus Mycelium|DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study To Evaluate The Safety And Tolerability Of PF-06252616 In Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: PF-06252616|DRUG: Placebo|BIOLOGICAL: PF-06252616|DRUG: Placebo|BIOLOGICAL: PF-06252161|DRUG: Placebo|BIOLOGICAL: PF-06252616|DRUG: Placebo|BIOLOGICAL: PF-06252616|DRUG: Placebo|BIOLOGICAL: PF-06252616|DRUG: Placebo|BIOLOGICAL: PF-06252616|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of SEL-302 in Pediatric Subjects With MMA
Status: SUSPENDED
Conditions: Methylmalonic Acidemia (MMA)
Interventions: DRUG: SEL-302
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imaging of ER Density to Guide and Improve Tailored Therapy for Acquired Anti-hormonal Resistant Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: Diagnostic intervention: Positron Emission Tomography with 16-alpha-[18-fluoro]-17betaestradiol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: DEvice-Detected CArdiac Tachyarrhythmic Events and Sleep-disordered Breathing (DEDiCATES)
Status: UNKNOWN
Conditions: Sleep Disorder|Cardiac Arrythmias|Cardiac Event|Cardiac Implantable Electronic Device
Interventions: DIAGNOSTIC_TEST: Device interrogation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessing the PrEP Care Cascade Among Black Men and Transwomen in the Southeastern US
Status: RECRUITING
Conditions: HIV Seropositivity|Substance Use|STI|Stigma, Social
Interventions: BEHAVIORAL: Stigma counseling for PrEP use
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Injection Methods in Finding the Sentinel Lymph Node During Lymphatic Mapping and Sentinel Lymph Node Biopsy in Patients With Invasive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Isosulfan Blue|PROCEDURE: Lymphangiography|RADIATION: Technetium Tc 99m sulfur colloid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phosphodiesterase 4 Inhibitor, Roflumilast, and the Effects of Inhibition in Severe Asthma
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: Roflumilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating Stress-Induced Dopamine Release: a fMRI-PET Study
Status: RECRUITING
Conditions: Stress Response
Interventions: DEVICE: tDCS actif|DEVICE: tDCS Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Link for Equity (School Staff Population)
Status: COMPLETED
Conditions: Behavior
Interventions: BEHAVIORAL: Immediate Universal Trauma-Informed Care and Cultural Humility Training|BEHAVIORAL: Waitlisted Universal Trauma-Informed Care and Cultural Humility Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of EXP039 Treatment in Subjects With r/r NHL Subjects
Status: UNKNOWN
Conditions: Non-Hodgkin's B-cell Lymphoma
Interventions: BIOLOGICAL: CD19/CD20-directed CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Watershift - Pilot Study
Status: COMPLETED
Conditions: Total Body Water|Nocturnal Polyuria
Interventions: DIAGNOSTIC_TEST: Bio Impedance assesement (BIA)|DIAGNOSTIC_TEST: Blood and salava sample|DIETARY_SUPPLEMENT: Ingestion of deuterated water|DIAGNOSTIC_TEST: Urine sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Persistence of Bactericidal Antibodies in Adolescents and Adults Who Had Received a Single Dose of Menactra® Vaccine
Status: COMPLETED
Conditions: Meningococcal Infections|Meningitis
Interventions: BIOLOGICAL: Menactra®|BIOLOGICAL: Menomune®
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment Decision Making in African American Women Diagnosed With Triple Negative Breast Cancer
Status: COMPLETED
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Invasive Breast Carcinoma|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8|Triple-Negative Breast Carcinoma
Interventions: PROCEDURE: Discussion|OTHER: Interview|OTHER: Survey Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Neoadjuvant Combined Hormone Therapy in Premenopausal Women With Locally Advanced ER+/HER2- Breast Cancer
Status: UNKNOWN
Conditions: The Neoadjuvant Therapy
Interventions: DRUG: Ribocyclib, fulvestrant, triptorelin|DRUG: Doxorubicin, cyclophosphamide, paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey
Status: RECRUITING
Conditions: Alzheimer Disease|Mild Cognitive Impairment|Dementia|Cognitive Decline|Cognitive Impairment|Memory Impairment
Interventions: OTHER: PrecivityAD2(TM) blood test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ultrasound Comparison of Radial Artery Hyperplasia After Use of a 7F Sheathless Guide vs. 6F Sheath/Guide Combination
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: 7F sheathless Guide Catheter|DEVICE: 6F Sheath/Guide Catheter Combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison Between the Effects of Conventional Diets vs Intermittent Fasting Diabetic and Pre-diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|PreDiabetes
Interventions: BEHAVIORAL: Calorie Restriction|BEHAVIORAL: Time Restricted Feeding|BEHAVIORAL: Time Restricted Feeding with Calorie Restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Muscle Derived Cell Therapy for Bladder Exstrophy Epispadias Induced Incontinence
Status: TERMINATED
Conditions: Bladder Exstrophy|Urinary Incontinence
Interventions: DRUG: MDC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Population Effects of Antiretroviral Therapy to Reduce HIV Transmission (PopART)
Status: COMPLETED
Conditions: HIV
Interventions: OTHER: Universal Testing with immediate ART|OTHER: Universal Testing with ART eligibility according to National Guidelines|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Primary Stability of Implant in Closed Sinus Lifting Cases Using Densah Bur Versus Osteotome
Status: UNKNOWN
Conditions: Sinus Pneumatization
Interventions: OTHER: closed sinus lifting by Osteotome|OTHER: closed sinus lifting by Densah bur
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Facilitating the Implementation of Interim Methadone to Increase Treatment Access
Status: COMPLETED
Conditions: Opioid-use Disorder
Interventions: OTHER: Usual Practice|OTHER: Implementation Facilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Low-dose Esmolol on Myocardial Injury After Non-cardiac Surgery in Elderly Frail Patients
Status: RECRUITING
Conditions: Frailty|Esmolol|Myocardial Injury
Interventions: DRUG: Esmolol|DRUG: Placebo Comparator: Placebo Comparator:normal saline(0.9%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Open Label Study of Tolerability, Pharmacokinetics and Pharmacodynamics of BCD-054 (Pegylated Interferon Beta-1a), IM and SC, Compared to Rebif® and Avonex® in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BCD-054|DRUG: Rebif|DRUG: Avonex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesia by Transversus Abdominis Plane Nerve Block in Patients Undergoing Liver Resection.
Status: TERMINATED
Conditions: Liver Cancer, Adult
Interventions: DRUG: RopivacaIne chlorhydrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Phase I Microdosing Study of ORM-14540 and ORM-12741
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ORM-14540|DRUG: ORM-12741
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: MINIMUM EFFECTIVE VOLUME OF BUPIVACAİNE FOR ANTERIOR SUPRASCAPULAR NERVE BLOCK
Status: COMPLETED
Conditions: Shoulder Pain|Supraspinatus Tendinitis|Bankart Lesions
Interventions: PROCEDURE: anterior supra scapular nerve block
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Sahlgrenska Anti-VEGF Study
Status: RECRUITING
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: Bevacizumab Injection|DRUG: Aflibercept Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Pregnenolone on Perceived Social Isolation
Status: TERMINATED
Conditions: Perceived Social Isolation
Interventions: DRUG: Pregnenolone 175mg|DRUG: Pregnenolone 400mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Polyoxidonium® in Hospitalized Patients With Coronavirus Disease COVID-19
Status: COMPLETED
Conditions: Infections, Coronavirus
Interventions: DRUG: azoximer bromide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency, Perineural Injection, Idiopathic Carpal Tunnel Syndrome
Status: UNKNOWN
Conditions: Carpal Tunnel Syndrome
Interventions: DRUG: mehylprednisolone injection|DEVICE: pulsed radiofrequency (PRF)|BIOLOGICAL: platelet-rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery
Status: TERMINATED
Conditions: Rheumatoid Arthritis|Osteoarthritis|Post-traumatic Arthritis|Collagen Disorders|Avascular Necrosis|Nonunion of Femoral Fractures|Congenital Hip Dysplasia|Slipped Capital Femoral Epiphysis
Interventions: DEVICE: DePuy ASR Hip System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autoimmunity in Retinitis Pigmentosa
Status: UNKNOWN
Conditions: Retinitis Pigmentosa
Interventions: DRUG: twice-daily dosage with 0.5% cyclosporine-A eyedrops
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A PH I Pilot Imaging Study to Evaluate Molecular Imaging Methods in HVs and pSS Pts
Status: COMPLETED
Conditions: Autoimmune Diseases
Interventions: RADIATION: 18F-FDG PET/CT Imaging|RADIATION: 11C-MET PET/CT Imaging|PROCEDURE: MRI Imaging with intravenous contrast with gadoterate meglumine|PROCEDURE: Minor Salivary gland (labial) biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pazopanib as Second Line Therapy in Patients With Metastatic Prostate Cancer Refractory to Total Androgen Blockade
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Pazopanib (GW786034)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy During Surgery in Treating Older Women With Stage I Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: axillary lymph node dissection|PROCEDURE: conventional surgery|PROCEDURE: sentinel lymph node biopsy|RADIATION: intraoperative radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intraoperative Ankle Nerve Blocks on Postoperative Discharge in Patients Undergoing Orthopaedic Foot Surgery
Status: COMPLETED
Conditions: Operative Incision
Interventions: PROCEDURE: general anesthesia|PROCEDURE: ankle block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Clinical Study on Treating Acute Gouty Arthritis Using Both Internal and External Therapy of Tonifying Spleen and Descending Turbid
Status: UNKNOWN
Conditions: Acute Gouty Arthritis
Interventions: DRUG: diclofenac sodium enteric-coated|DRUG: Oral medicine of tonifying spleen and descending turbid|DRUG: Steeping and washing medicine of descending turbid and clearing heat|DRUG: Wet wrapping medicine of descending turbid and clearing heat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial
Status: RECRUITING
Conditions: Castration-Resistant Prostate Carcinoma|Metastatic Colorectal Carcinoma|Metastatic Malignant Neoplasm in the Bone|Metastatic Malignant Solid Neoplasm|Metastatic Melanoma|Metastatic Prostate Carcinoma|Metastatic Renal Cell Carcinoma|Metastatic Sarcoma|Metastatic Thyroid Gland Carcinoma|Metastatic Urothelial Carcinoma|Stage IV Colorectal Cancer AJCC v8|Stage IV Prostate Cancer AJCC v8|Stage IV Renal Cell Cancer AJCC v8|Stage IVA Colorectal Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8|Stage IVB Colorectal Cancer AJCC v8|Stage IVB Prostate Cancer AJCC v8|Stage IVC Colorectal Cancer AJCC v8
Interventions: PROCEDURE: Cryosurgery|OTHER: Quality-of-Life Assessment|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study Using Functional Magnetic Resonance Imaging (fMRI) to Assess the Effects of Naltrexone SR/ Bupropion SR Therapy in Overweight or Obese Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Naltrexone SR 32 mg/bupropion SR 360 mg/day|DRUG: Placebo|OTHER: fMRI scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Aripiprazole (Abilify) in Children With Symptoms of Mania
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Aripiprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Dermocorticoids on Bone Mineral Density in Patients With Bullous Pemphigoid
Status: RECRUITING
Conditions: Osteoporosis|Bullous Pemphigoid
Interventions: PROCEDURE: bone densitometry|BIOLOGICAL: blood test|PROCEDURE: radiographs of the thoracic and lumbar spine|PROCEDURE: Clobetasol propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Equivalence of GDC-229 and Metronidazole Vaginal Gel 0.75% in the Treatment of Bacterial Vaginosis
Status: COMPLETED
Conditions: Bacterial Vaginosis
Interventions: DRUG: GDC-229|DRUG: Metronidazole Vaginal Gel 0.75%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Research Study to Look at How CagriSema Influences Food Intake, Appetite and Emptying of the Stomach in People With Excess Body Weight
Status: RECRUITING
Conditions: Obesity
Interventions: DRUG: Cagrilintide|DRUG: Semaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mevrometostat Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma
Status: RECRUITING
Conditions: Metastatic Castration Resistant Prostate Cancer (mCRPC)|Small Cell Lung Cancer (SCLC)|Follicular Lymphoma (FL)
Interventions: DRUG: Mervometostat (PF-06821497)|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Lumateperone in Pediatric Patients With Schizophrenia or Schizoaffective Disorder
Status: COMPLETED
Conditions: Schizophrenia|Pediatric
Interventions: DRUG: Lumateperone 42 mg|DRUG: Lumateperone 28 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Course Rifapentine and Isoniazid for the Preventive Treatment for Latent Genital Tuberculosis
Status: UNKNOWN
Conditions: Infertility, Female|Recurrent Implantation Failure|Genital Tuberculoses, Female|Genital Tuberculosis, Latent
Interventions: DRUG: rifapentine plus isoniazid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multivariate Assessment of the IUB Intrauterine Device Compared With a T380A IUD
Status: COMPLETED
Conditions: To Assess the Safety, Effectiveness and User Experience of the Scu 300A IUB
Interventions: DEVICE: SCu300A IUB intrauterine device|DEVICE: T380A IUD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Eribulin Mesylate in Treating Patients With Metastatic Prostate Cancer That Did Not Respond to Hormone Therapy
Status: COMPLETED
Conditions: Adenocarcinoma of the Prostate|Hormone-refractory Prostate Cancer|Recurrent Prostate Cancer|Stage IV Prostate Cancer
Interventions: DRUG: eribulin mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Tarlatamab in Chinese Participants With Advanced Small Cell Lung Cancer After Two or More Prior Lines of Treatment
Status: NOT_YET_RECRUITING
Conditions: Advanced Small Cell Lung Cancer
Interventions: DRUG: Tarlatamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Serum Markers for Cardiovascular Risk in Obese Youth and Impact of Lifestyle and Medication Intervention
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Metformin|BEHAVIORAL: Dietary modification with caloric restriction|BEHAVIORAL: Establishment of exercise protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Theophylline for Depression Study
Status: WITHDRAWN
Conditions: Depression
Interventions: DRUG: Theophylline ER|OTHER: PO placebo|BIOLOGICAL: Lipopolysaccharide (LPS)|OTHER: IV placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Antiviral Activity and Safety of 3 Different Doses of Mifepristone in Hepatitis C Infected Patients
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: VGX-410 (Mifepristone)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radiolabeled Monoclonal Antibody Therapy, Fludarabine Phosphate, and Low-Dose Total-Body Irradiation Followed by Donor Stem Cell Transplant and Immunosuppression Therapy in Treating Older Patients With Advanced Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Chronic Myelomonocytic Leukemia|de Novo Myelodysplastic Syndromes|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Myeloid Leukemia|Refractory Anemia With Excess Blasts|Refractory Anemia With Excess Blasts in Transformation|Refractory Anemia With Ringed Sideroblasts|Refractory Cytopenia With Multilineage Dysplasia|Secondary Myelodysplastic Syndromes|Untreated Adult Acute Myeloid Leukemia
Interventions: RADIATION: iodine I 131 monoclonal antibody BC8|RADIATION: total-body irradiation|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation|DRUG: fludarabine phosphate|DRUG: cyclosporine|DRUG: mycophenolate mofetil|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of M254 in Healthy Volunteers and Immune Thrombocytopenic Purpura (ITP) Patients
Status: TERMINATED
Conditions: Immune Thrombocytopenic Purpura (ITP)
Interventions: BIOLOGICAL: Biological: M254|DRUG: Placebo|BIOLOGICAL: Intravenous immunoglobulin (IVIg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Apical Patency Concept Upon Postoperative Pain After Root Canal Treatment
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: apical patency|PROCEDURE: Non-apical surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability of Artificial Tears in Dry Eye Subjects
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: Formulation 1: Carboxymethylcellulose Sodium, Glycerin and Polysorbate 80, based artificial tear|DRUG: Formulation 2: Carboxymethylcellulose Sodium, Glycerin and Polysorbate 80, based artificial tear|DRUG: Glycerin and Polysorbate 80 based artificial tear
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: QUILT-3.050: NANT Colorectal Cancer (CRC) Vaccine: Combination Immunotherapy in Subjects With Recurrent or Metastatic CRC
Status: WITHDRAWN
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: avelumab|BIOLOGICAL: bevacizumab|DRUG: capecitabine|BIOLOGICAL: cetuximab|DRUG: Cyclophosphamide|DRUG: 5-Fluorouracil (5-FU)|DRUG: fulvestrant|DRUG: leucovorin|DRUG: nab paclitaxel|BIOLOGICAL: nivolumab|DRUG: Lovaza|DRUG: oxaliplatin|RADIATION: Stereotactic Body Radiation Therapy|BIOLOGICAL: ALT-803|BIOLOGICAL: ETBX-011|BIOLOGICAL: ETBX-021|BIOLOGICAL: ETBX-051|BIOLOGICAL: ETBX-061|BIOLOGICAL: GI-4000|BIOLOGICAL: GI-6207|BIOLOGICAL: GI-6301|BIOLOGICAL: haNK
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First in Human Study to Evaluate the Safety and Immune Response to a Vaccine for the Treatment of a Respiratory Virus, When Administered Into the Arm in Healthy Adult Participants
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: Respiratory Syncytial Vaccine|BIOLOGICAL: Respiratory Syncytial Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Evaluating Lanreotide as Maintenance Therapy in Patients With Non-Resectable Duodeno-Pancreatic Neuroendocrine Tumors (REMINET)
Status: TERMINATED
Conditions: Metastatic/Locally Advanced, Non-resectable, Duodeno-pancreatic Neuroendocrine Tumours
Interventions: DRUG: lanreotide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotic Effect on Gastrointestinal Symptoms (FLORABIOTIC REFUERZO).
Status: RECRUITING
Conditions: Probiotic|Gastrointestinal Symptoms|Microbiota
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sequential Trial of G17DT for the Treatment of Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: G17DT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of MedCem MTA and Formocresol Used in Pulpotomies in Primary Teeth.
Status: COMPLETED
Conditions: Pulpotomies Primary Teeth|Effectiveness of MedCem MTA® in Pulpotomies Primary Teeth
Interventions: PROCEDURE: MedCem MTA pulpotomies in primary teeth.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy of Chloroquine in the Treatment of Ductal Carcinoma in Situ (The PINC Trial)
Status: COMPLETED
Conditions: Carcinoma, Intraductal, Noninfiltrating|DCIS|Ductal Carcinoma In Situ
Interventions: DRUG: Chloroquine Standard Dose (500mg/week)|DRUG: Chloroquine Low Dose (250mg/week)|PROCEDURE: Breast Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LDX for the Treatment of Cognitive Functioning Issues in Women Post-Oophorectomy
Status: WITHDRAWN
Conditions: Cognitive Impairments|RRSO
Interventions: DRUG: lisdexamfetamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Long-term Immunogenicity and Safety of a Human Papillomavirus (HPV) Vaccine in Healthy Female Subjects.
Status: COMPLETED
Conditions: Infections, Papillomavirus|Papillomavirus Vaccines
Interventions: PROCEDURE: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vaccine Therapy Plus Interleukin-12 in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: PSA prostate cancer vaccine|BIOLOGICAL: recombinant interleukin-12
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Oral Danazol (a Previously Approved Drug) in the Treatment of Diabetic Macular Edema.
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Danazol Capsules|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study to Evaluate the Safety and Tolerability of Multiple Infusions of BPS804 in Adults With Hypophosphatasia (HPP)
Status: COMPLETED
Conditions: Hypophosphatasia
Interventions: DRUG: BPS804
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of ADI-PEG 20 Plus Lenvatinib Treatment in Subjects With Unresectable Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: ADI-PEG20
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)
Status: RECRUITING
Conditions: Obesity|Weight Gain
Interventions: DRUG: Tirzepatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tucatinib (MK-7119) in Combination With Trastuzumab and Capecitabine in Participants With Previously Treated Locally Advanced Unresectable or Metastatic Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Breast Carcinoma (MK-7119-001)
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Tucatinib|BIOLOGICAL: Trastuzumab|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine as Adjunctive Therapy for Alcohol Withdrawal
Status: COMPLETED
Conditions: Acute Alcohol Withdrawal
Interventions: DRUG: Dexmedetomidine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treo/Flu/TBI With Donor Stem Cell Transplant for Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia in Remission|Chronic Myelomonocytic Leukemia|Minimal Residual Disease|Myelodysplastic Syndrome|Myelodysplastic/Myeloproliferative Neoplasm|Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable
Interventions: PROCEDURE: Allogeneic Bone Marrow Transplantation|DRUG: Fludarabine Phosphate|PROCEDURE: Peripheral Blood Stem Cell Transplantation|RADIATION: Total-Body Irradiation|DRUG: Treosulfan|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebrolysin in Prevention of Postoperative Delirium in Cardiac Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Neurocognitive Disorders|Surgery-Complications|Critical Illness|Brain Damage|Cardiac Disease
Interventions: DRUG: Cerebrolysin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Fluid Resuscitation With 0.9% Sodium Chloride Versus Balanced Crystalloid Solution on Renal Function of Sepsis Patients
Status: COMPLETED
Conditions: Sepsis|Septic Shock|Acute Kidney Injury
Interventions: DRUG: Normal saline|DRUG: Ringer's Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Vibration Stimulation Combined With Task-oriented Training on Hand Motor Function in Chronic Stroke
Status: COMPLETED
Conditions: Rehabilitation|Stroke|Hand Grasp
Interventions: DEVICE: Vibration stimulation combined with task-oriented training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: THE EFFETCS OF NON-SURGICAL PERIODONTAL TREATMENT ON SALIVARY BIOMARKERS OF PATIENTS WITH OSTEOPOROSIS AND PERIODONTITIS
Status: COMPLETED
Conditions: Osteoporosis|Periodontitis
Interventions: PROCEDURE: non-surgical periodontal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Stereotactic Aspiration Plus Urokinase in Deep Intracerebral Hemorrhage Evacuation
Status: UNKNOWN
Conditions: Treatment of Spontaneous Intracerebral Hemorrhage
Interventions: PROCEDURE: STAPLE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: REduction of Post-Operative Urinary Retention With Tamsulosin Versus Placebo (REPOURT- P) Trial
Status: UNKNOWN
Conditions: Urinary Catheterization|Thoracic Surgery|Thoracic Epidural Analgesia
Interventions: DRUG: Tamsulosin Hydrochloride|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Periodontal Regeneration Using Dental Pulp Stem Cells (DPSCs)
Status: COMPLETED
Conditions: Periodontal Diseases
Interventions: PROCEDURE: periodontal regeneration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Identification of Biomarkers for Acute Intake of Beer and Alcohol and Acute Effects on Plasma and Insulin Response
Status: COMPLETED
Conditions: Alcohol Consumption|Insulin Resistance
Interventions: OTHER: Beverage sequence ABCD|OTHER: Beverage sequence CADB|OTHER: Beverage sequence DACB|OTHER: Beverage sequence CBAD|OTHER: Beverage sequence ABDC|OTHER: Beverage sequence DABC|OTHER: Beverage sequence DCAB|OTHER: Beverage sequence DBCA|OTHER: Beverage sequence ADCB|OTHER: Beverage sequence BADC|OTHER: Beverage sequence ACDB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tongue Morphology and Posterior Airway Space as Predictors of Response in Patientswith Hypoglossal Nerve Stimulation Therapy
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Sleep-Disordered Breathing
Interventions: DIAGNOSTIC_TEST: Ultrasonography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study of Topographic Imaging of the Calf Muscle in Patients With PAD Using 3D Reconstruction of MSOT Images
Status: UNKNOWN
Conditions: Peripheral Vascular Diseases|Peripheral Arterial Disease
Interventions: DEVICE: Multispectral Optoacoustic Tomography (MSOT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Safety and Efficacy of Intravenous Iron Versus Oral Iron in Chronic Renal Failure Subjects With Anemia
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Venofer|DRUG: Ferrous Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced Opioid Analgesic Requirements Via Improved Endogenous Opioid Function
Status: COMPLETED
Conditions: Chronic Pain
Interventions: BEHAVIORAL: 6 week aerobic exercise intervention|DRUG: Placebo|DRUG: Morphine|DRUG: naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT