pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluation Of SB-751689 Administered At Supratherapeutic Dose Levels In Healthy Adult Subjects.
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: SB-751689 oral tablets (100 and 400 ng)|DRUG: Ketoconazole (NIZORAL) oral tablets (200 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Clinical Trial to Evaluate the Recombinant Vaccine for COVID-19 (Adenovirus Vector)
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Recombinant novel coronavirus vaccine (Adenovirus type 5 vector)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of DHEA on Skin Aging in Postmenopausal Women
Status: COMPLETED
Conditions: Skin Aging|Quality of Life
Interventions: DRUG: Dehydroepiandrosterone|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease Modifying Anti-rheumatic Drugs or Had Previously Received TNFα Inhibitor Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Psoriatic Arthritis
Interventions: DRUG: Deucravacitinib|OTHER: Placebo|DRUG: Apremilast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Low Dose Combination of LTG and VPA Compared to CBZ Monotherapy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Carbamazepine|DRUG: Lamotrigine/Valproate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Versus Chemotherapy for Endometrial Carcinoma (ENGOT-en9 / MK-7902-001) - China Extension Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Neoplasms
Interventions: DRUG: Lenvatinib|BIOLOGICAL: Pembrolizumab|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of UCN-01 in Metastatic Melanoma
Status: TERMINATED
Conditions: Recurrent Melanoma|Stage IV Melanoma
Interventions: DRUG: 7-hydroxystaurosporine|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Zipalertinib in Patients With Advanced Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions or Other Uncommon Mutation.
Status: RECRUITING
Conditions: Advanced or Metastatic NSCLC Harboring Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion (ex20ins) Mutations
Interventions: DRUG: TAS6417
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer
Status: RECRUITING
Conditions: Testicular Neoplasms|Seminoma
Interventions: DRUG: Bleomycin Etoposide and Cisplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Etavopivat in Patients With Thalassemia or Sickle Cell Disease
Status: RECRUITING
Conditions: Sickle Cell Disease|Thalassemia
Interventions: DRUG: Etavopivat tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rebeccamycin Analog and Cisplatin With or Without Filgrastim in Treating Patients With Advanced Cancer
Status: COMPLETED
Conditions: Lymphoma|Small Intestine Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: filgrastim|DRUG: becatecarin|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-blind, Vehicle Controlled, Repeat Dose Comparative Study in RA Patients Managed With DMARDs
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Low dose ORTD-1|DRUG: Low dose vehicle control|DRUG: High dose ORTD-1|DRUG: High dose vehicle control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Trial of mBACOD and Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in AIDS-Associated Large Cell, Immunoblastic, and Small Non-cleaved Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin|HIV Infections
Interventions: DRUG: Bleomycin sulfate|DRUG: Vincristine sulfate|DRUG: Doxorubicin hydrochloride|DRUG: Cyclophosphamide|DRUG: Methotrexate|DRUG: Cytarabine|DRUG: Leucovorin calcium|DRUG: Sargramostim|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Paracetamol, Dexketoprofen Trometamol, Lidocaine Spray, Pethidine and Diclofenac Sodium Application for Pain Relief During Fractional Curettage
Status: COMPLETED
Conditions: Pain and Curettage
Interventions: DRUG: comparison of pain relievers during curattage|DRUG: comparison of pain relievers|DRUG: comparison of pain relievers during curattage|DRUG: comparison of pain relievers during curattage|DRUG: comparison of pain relievers during curattage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Efficacy and Safety of CKD-495
Status: COMPLETED
Conditions: Gastritis
Interventions: DRUG: CKD-495 75mg|DRUG: Artemisia Herb 95% Ethanol Soft Ext.(20→1) 60mg|DRUG: Placebo of the CKD-495 75mg|DRUG: Placebo of Artemisia Herb 95% Ethanol Soft Ext.(20→1) 60mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of Myocardial Perfusion Imaging
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: coronary angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: SGI-110 in Combination With an Allogeneic Colon Cancer Cell Vaccine (GVAX) and Cyclophosphamide (CY) in Metastatic Colorectal Cancer (mCRC)
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: CY|BIOLOGICAL: GVAX|DRUG: SGI-110
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab, Paclitaxel, and Carboplatin Before Surgery in Treating Patients With Stage IB, Stage II, or Stage IIIA Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: carboplatin|DRUG: paclitaxel|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Analgesic Efficacy of a Modified Auriculotemporal Nerve Block
Status: RECRUITING
Conditions: Safety and Efficacy|Scalp Nerve Block
Interventions: PROCEDURE: a modified auriculotemporal nerve blockade|PROCEDURE: Traditional auriculotemporal nerve blockade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Fenfuro (Fenugreek Seed Extract) in Type-2 Diabetic Subjects: an add-on Study
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Fenfuro
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Adductor Canal Block After Total Knee Replacement - a Suture-method Catheter vs a Standard Catheter vs a Single Bolus
Status: COMPLETED
Conditions: Pain Management
Interventions: DRUG: Initial bolus (Certa and standard catheter groups)|DRUG: Initial bolus (Single bolus group)|DRUG: Intermittent boluses (Certa and standard catheter groups)|DRUG: Intermittent boluses (Single bolus group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Absorption and Tolerability Studies of an Emulsion Containing the Coconut Oil-derived Glycerol Tridecanoate in Healthy Men
Status: WITHDRAWN
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Glyceryl Tridecanoate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Verify the Effectiveness and Safety of Isothymol or Carvacrol Compound Against SARS-CoV-2 in COVID-19 Patients
Status: COMPLETED
Conditions: COVID-19|COVID-19 Pneumonia|COVID-19 Respiratory Infection|COVID-19 Acute Respiratory Distress Syndrome|COVID-19 Lower Respiratory Infection
Interventions: DRUG: Carvacrol|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of MC in Paediatric Palliative Care
Status: RECRUITING
Conditions: Palliative Care
Interventions: DRUG: Medicinal Cannabis - C12T12|DRUG: Medicinal Cannabis - C20T5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Tolerability and Pharmacokinetics of ERX-963 in Adults With Myotonic Dystrophy Type 1
Status: COMPLETED
Conditions: Myotonic Dystrophy, Type 1 (DM1)|Myotonic Dystrophy
Interventions: DRUG: ERX-963|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized Self-Management Training Compared to Standardized Self-Management Training in Colorectal Cancer Patients.
Status: RECRUITING
Conditions: Colorectal Cancer|Healthy Lifestyle|Behavior, Health|Health Behavior
Interventions: BEHAVIORAL: RISE Personalized Self-Managament Training (PSMT)|BEHAVIORAL: Standardized Self-Managament Training (SSMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Endotoxin and Inflammatory Markers in Healthy Non-Smokers and Current Smokers Including Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: WITHDRAWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: PROCEDURE: Inhalation of LPS|PROCEDURE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Duloxetine Versus Placebo in the Prevention of Recurrence of Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Duloxetine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Randomized Trial of Ambulatory Exercise in Pulmonary Hypertension
Status: WITHDRAWN
Conditions: Pulmonary Arterial Hypertension
Interventions: BEHAVIORAL: Usual Care|BEHAVIORAL: Home-based exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Effects of Itraconazole and Rifampin on Selpercatinib (LY3527723) in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Selpercatinib|DRUG: Itraconazole|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Surgical Stabilisation of Rib Fractures in Non-ventilated Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Rib Fractures|Thorax; Fracture
Interventions: PROCEDURE: Surgical stabilisation of rib fractures (SSRF)|OTHER: Non-operative management of rib fractures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adverse Effects of ALA-PDT for the Treatment of Moderate to Severe Acne Vulgaris: a Prospective Study
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: OTHER: Aminolevulinic acid, photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Mangoselect® in Improvement of Exercise/Activity-induced Knee Joint Discomfort in Subjects Suffering From Osteoarthritis Grade I or II
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Verum A|DIETARY_SUPPLEMENT: Verum B|DIETARY_SUPPLEMENT: Verum C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hemodynamic Changes During Displacement of the Heart in the Aorta No-touch Off-pump Coronary Artery Bypass Surgery
Status: UNKNOWN
Conditions: Cardiac Surgery|Aorta No-touch
Interventions: PROCEDURE: Aorta no-touch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraindividual Comparison of EMO IOLs
Status: RECRUITING
Conditions: Age Related Cataracts
Interventions: PROCEDURE: phacoemulsification and intraocular lens implantation|PROCEDURE: phacoemulsification and intraocular lens implantation|PROCEDURE: phacoemulsification and intraocular lens implantation|PROCEDURE: phacoemulsification and intraocular lens implantation|PROCEDURE: phacoemulsification and intraocular lens implantation|PROCEDURE: phacoemulsification and intraocular lens implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Phenoptin in Subjects With Phenylketonuria Who Participated in Protocols PKU-004 or PKU-006
Status: COMPLETED
Conditions: Phenylketonuria
Interventions: DRUG: sapropterin dihydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Recovery, Excretion, and Pharmacokinetics of 14C -GSK1322322 After an Intravenous and an Oral Dose
Status: COMPLETED
Conditions: Infections, Bacterial
Interventions: DRUG: GSK1322322 1000 mg containing radioactive 14C-GSK1322322|DRUG: GSK1322322 1200 mg containing radioactive 14C-GSK1322322
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sitagliptin and Glucagon Counterregulation
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Sitagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Telmisartan 80mg Plus Hydrochlorothiazide 25mg First Line in Moderate or Severe Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan|DRUG: Telmisartan|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Total Hip Prosthesis Assisted by Computer
Status: COMPLETED
Conditions: Clinic Hip Osteoarthrosis
Interventions: PROCEDURE: Prosthetic hip surgery, operated under manual control|PROCEDURE: Prosthetic hip surgery operated under navigation based on EOS imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: DBRCT on the Effect of Grip Strength in Brachial Plexus vs Distal Forearm Nerve Blocks
Status: COMPLETED
Conditions: Postoperative Mobility
Interventions: PROCEDURE: Proximal Brachial Plexus vs Distal Forearm Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Plant Sterol-Fortified Dairy Product on Plasma Lipid and Plant Sterol Concentrations in Humans
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: WD-PS intervention phase|DIETARY_SUPPLEMENT: PS-Ester intervention phase|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Barriers to Beginning and Finishing Treatment for Patients With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: educational intervention|OTHER: informational intervention|OTHER: medical chart review|OTHER: questionnaire administration|OTHER: study of socioeconomic and demographic variables|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Randomized DB Controlled Trial of Botulinum Toxin A in Hemiplegic Shoulder Pain and Spasticity
Status: COMPLETED
Conditions: Post-stroke Shoulder Pain and Spasticity
Interventions: DRUG: Botulinum Toxin Type A - OnabotulinumtoxinA|DRUG: Placebo (Saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selinexor and Pembrolizumab for the Treatment of Cisplatin-Ineligible or Cisplatin-Refractory Locally Advanced or Metastatic Urothelial Carcinoma
Status: RECRUITING
Conditions: Advanced Urothelial Carcinoma|Locally Advanced Urothelial Carcinoma|Metastatic Urothelial Carcinoma|Refractory Urothelial Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of SHR0302 in Patients With Relapsed/Refractory Peripheral T/NK Cell Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Peripheral T Cell Lymphoma
Interventions: DRUG: SHR0302
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of HL-009 Liposomal Gel to Treat Mild to Moderate Atopic Dermatitis
Status: COMPLETED
Conditions: Mild to Moderate Atopic Dermatitis
Interventions: DRUG: HL-009 Liposomal Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Evacetrapib (LY2484595) in Participants With Severe Renal Impairment and in Healthy Participants
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DRUG: Evacetrapib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparing Standard of Care Chemotherapy Treatment to the Combination of Copanlisib and Olaparib for Recurrent Platinum Resistant Ovarian Cancer That Has Progressed Through PARP Inhibitor Therapy
Status: WITHDRAWN
Conditions: Platinum-Refractory Fallopian Tube Carcinoma|Platinum-Refractory Ovarian Carcinoma|Platinum-Refractory Primary Peritoneal Carcinoma|Recurrent Fallopian Tube Endometrioid Adenocarcinoma|Recurrent Fallopian Tube High Grade Serous Adenocarcinoma|Recurrent Ovarian Endometrioid Adenocarcinoma|Recurrent Ovarian High Grade Serous Adenocarcinoma|Recurrent Platinum-Resistant Fallopian Tube Carcinoma|Recurrent Platinum-Resistant Ovarian Carcinoma|Recurrent Platinum-Resistant Primary Peritoneal Carcinoma|Recurrent Primary Peritoneal Endometrioid Adenocarcinoma|Recurrent Primary Peritoneal High Grade Serous Adenocarcinoma
Interventions: PROCEDURE: Computed Tomography|DRUG: Copanlisib Hydrochloride|PROCEDURE: Magnetic Resonance Imaging|DRUG: Olaparib|DRUG: Paclitaxel|DRUG: Pegylated Liposomal Doxorubicin Hydrochloride|DRUG: Topotecan Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local and Widespread Hypoalgesic Effects of Neurodynamic Mobilization in Healthy Controls
Status: COMPLETED
Conditions: Pain|Pain, Neuropathic
Interventions: OTHER: Neurodynamic Slider Mobilization|OTHER: Neurodynamic Tensioner Mobilization|OTHER: Sham Neurodynamic Mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Assess The Efficacy And Safety Of Vismodegib And Radiotherapy In Advanced Basal Cell Carcinoma
Status: TERMINATED
Conditions: Carcinoma, Basal Cell
Interventions: DRUG: Vismodegib|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Assess the Feasibility of a Novel Non-invasive Technology to Measure Changing Blood Glucose Levels in Adults With Type-1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus|Type 1 Diabetes Mellitus With Hypoglycemia|Type 1 Diabetes Mellitus With Hyperglycemia
Interventions: DEVICE: Lab Demo 1.0
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Brain Boosters 2 in Persons at Risk for Alzheimer's Disease: a Digital Application Supported Intervention
Status: ACTIVE_NOT_RECRUITING
Conditions: Memory Disorders|Cognitive Impairment
Interventions: BEHAVIORAL: Self-Guided|BEHAVIORAL: Structured Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy (Preliminary) and Safety of Artificial Salivary Containing Cumin and Ginger Extract in Healthy Volunteer
Status: RECRUITING
Conditions: Health, Subjective
Interventions: COMBINATION_PRODUCT: Artificial salivary containing cumin and ginger extract|OTHER: Commercial artificial salivary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cytochrom p450 3A4 and 1A2 Phenotyping for the Individualization of Treatment With Sunitinib or Erlotinib in Cancer Patients
Status: COMPLETED
Conditions: Non Small-cell Lung Cancer|Renal-cell Cancer|Gastrointestinal Stroma Tumor
Interventions: DRUG: Sunitinib|DRUG: Erlotinib|DRUG: Midazolam|DRUG: Caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Against TB Disease, Safety, and Immunogenicity of MVA85A/AERAS-485 in HIV-Infected Adults (C-030-485)
Status: COMPLETED
Conditions: Tuberculosis|HIV Infections
Interventions: BIOLOGICAL: MVA85A/AERAS-485|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Two-year Follow-up to High-intensity Multi-component Agility Intervention That Improves Clinical and Motor Symptoms of Parkinson's Disease
Status: COMPLETED
Conditions: Follow up|Parkinson Disease|Rehabilitation
Interventions: OTHER: Follow-up|OTHER: Post-treatment control|OTHER: Control Parkinson group
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nynnamm - Effects of Infant Directed Singing on Breastfeeding Difficulties
Status: NOT_YET_RECRUITING
Conditions: Breastfeeding
Interventions: BEHAVIORAL: Infant directed singing|BEHAVIORAL: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Humoral Response to SARS-CoV-2 Variants and of the Cellular Response After Vaccination Against COVID-19 in Immunocompromised People
Status: COMPLETED
Conditions: Autoimmune or Autoinflammatory Diseases|HIV|Multiple Sclerosis|Solid Tumors or Cancers|Solid Organ Transplant
Interventions: OTHER: Blood samples for the study of the humoral response to SARS-CoV-2 variants and of the cellular response after vaccination against COVID-19
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacoscintigraphic Investigation Into the Absorption of Nevirapine When Released Into Different Parts of the Gastro-intestinal Tract in Healthy Males
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Nevirapine suspension, into Enterion™ capsule|DRUG: Nevirapine suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oral Sulfate Solution on Bowel Preparation for Colonoscopy
Status: COMPLETED
Conditions: Bowel Preparation for Colonoscopy
Interventions: DRUG: Oral sulfate solution (OSS)|DRUG: Polyethylene Glycol Electrolyte
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Anti-histamines and Methacholine Challenges.
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Diphenhydramine|DRUG: cetirizine|DRUG: desloratadine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study Evaluating Bazedoxifene/Conjugated Estrogens Combinations In Healthy Postmenopausal Women
Status: COMPLETED
Conditions: Menopause
Interventions: DRUG: Bazedoxifene/Conjugated Estrogens 20 mg/0.625 mg tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Follow-up Protocols in Terms of Fetal, Neonatal and Maternal Results in Intrauterine Growth Retardation
Status: UNKNOWN
Conditions: Fetal Surveillance|Intrauterine Growth Restriction
Interventions: PROCEDURE: weekly|PROCEDURE: bi-weekly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Neurocognitive Mechanisms of Perimenstrual Estrogen Effects on Suicidality
Status: RECRUITING
Conditions: Suicide
Interventions: DRUG: Transdermal Estradiol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Circadin® 2 mg in Patients With Mild to Moderate Alzheimer Disease Treated With AChE Inhibitor
Status: COMPLETED
Conditions: Alzheimer's Disease|Sleep Disorder
Interventions: DRUG: Circadin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Performance of an Antigen Test for SARS-CoV-2 Infection (COVID-19)
Status: TERMINATED
Conditions: Covid-19
Interventions: DIAGNOSTIC_TEST: Quidel Sofia SARS Antigen FIA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluate the Effect of Diet on Gastrointestinal Adverse Events in Patients With IPF Treated With Pirfenidone
Status: COMPLETED
Conditions: Pulmonary Disease
Interventions: BEHAVIORAL: MUFA Diet|BEHAVIORAL: SFA Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PANGEA-IMBBP: Personalized Antibodies for Gastro-Esophageal Adenocarcinoma - A 1st Pilot Metastatic Trial of Biologics Beyond Progression
Status: COMPLETED
Conditions: Adenocarcinoma
Interventions: DRUG: Trastuzumab|DRUG: ABT-806|DRUG: Bemarituzumab|DRUG: Ramucirumab|DRUG: Nivolumab|DRUG: Standard cytotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NMDA Enhancement Combined With Omega-3 for Early Dementia
Status: NOT_YET_RECRUITING
Conditions: Omega 3 Fatty Acids|Dementia
Interventions: DRUG: DAOIB+Omega-3|DRUG: DAOIB+Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chlorhexidine Gluconate vs Povidone-Iodine Vaginal Cleansing Solution Prior to Cesarean Delivery
Status: COMPLETED
Conditions: Wound Infection|Complication, Postoperative
Interventions: PROCEDURE: Povidone Iodine|PROCEDURE: Chlorhexidine gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nitric Oxide Flux and Ureagenesis in Argininosuccinate Synthetase Deficiency (ASSD)(Citrullinemia I)
Status: COMPLETED
Conditions: Citrullinemia
Interventions: OTHER: stable isotope infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Study in Healthy Subjects to Assess the Safety, Tolerability and Pharmacokinetics of HTL0022562
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: HTL0022562|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adaptix RCT Evaluating Adaptix™ Versus PEEK Cages
Status: RECRUITING
Conditions: Spinal Canal Stenosis|Spondylolisthesis|Osteophyte|Bony Growth Formation|Degenerative Disc Disease
Interventions: DEVICE: Medtronic Adaptix™ titanium implants|DEVICE: Medtronic CAPSTONE® PEEK cage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Rising Oral Doses of BI 14332 CL Powder in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 14332 CL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a Single Dose of Intranasal Seasonal Trivalent Live-Attenuated Influenza Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: SIIL LAIV (live, trivalent seasonal influenza vaccine)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Different Dose of Intravenous Omeprazole to Treat Bleeding Ulcer With Adherent Clot
Status: COMPLETED
Conditions: Peptic Ulcer|Hemorrhage
Interventions: DRUG: omeprazole|DRUG: omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Extension Study of Reslizumab in Pediatric Subjects With Eosinophilic Esophagitis
Status: COMPLETED
Conditions: Eosinophilic Esophagitis
Interventions: DRUG: reslizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Absorption, Metabolism, Excretion, and Mass Balance of CT1812 in Healthy Adult Male Subjects
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: 300 mg [C14] CT1812
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Doxil Topotecan Doublet Cancer Study
Status: COMPLETED
Conditions: Small Cell Lung Cancer|Pancreatic Cancer|Head and Neck Cancer|Gastric Cancer|Esophageal Cancer
Interventions: DRUG: Topotecan and pegylated doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oral HBI-8000 in Patients With Relapsed or Refractory Adult T Cell Lymphoma (ATL)
Status: COMPLETED
Conditions: Adult T-Cell Lymphoma (ATL)
Interventions: DRUG: HBI-8000
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NIMRAD (A Randomised Placebo-controlled Trial of Synchronous NIMorazole Versus RADiotherapy Alone in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Not Suitable for Synchronous Chemotherapy or Cetuximab)
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Nimorazole|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of the Placental Malaria Vaccine Candidate PAMVAC Variously Adjuvanted
Status: COMPLETED
Conditions: Malaria, Antepartum
Interventions: BIOLOGICAL: PAMVAC|BIOLOGICAL: Alhydrogel|BIOLOGICAL: GLA-SE|BIOLOGICAL: GLA-LSQ|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Short-Acting BroNchodilator and Inhaled Corticosteroid Rescue Therapy on Health Outcomes in Routine Care
Status: RECRUITING
Conditions: Asthma
Interventions: DRUG: Albuterol and budesonide inhalation aerosol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Find Out How Safe Long-term Treatment With Fezolinetant is in Women With Hot Flashes Going Through Menopause
Status: COMPLETED
Conditions: Hot Flashes
Interventions: DRUG: fezolinetant|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Studying Conditioning Regimen In Pediatric Transplantation - AML , SCRIPT-AML
Status: RECRUITING
Conditions: Acute Myeloid Leukemia (AML) in Remission|Stem Cell Transplantation
Interventions: DRUG: busulfan, cyclophosphamide and melphalan, BuCyMel|DRUG: clofarabine, fludarabine and busulfan, CloFluBu
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy, Amifostine, and Radiation Therapy in Treating Patients With Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Drug/Agent Toxicity by Tissue/Organ|Lung Cancer
Interventions: DRUG: amifostine trihydrate|DRUG: carboplatin|DRUG: paclitaxel|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Educational Program About Preventive Care Bundle for Prevention of Ventilator Associated Pneumonia Among Newborns
Status: NOT_YET_RECRUITING
Conditions: Ventilator Associated Pneumonia
Interventions: OTHER: educational program about VAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: HA-1H TCR T Cell for Relapsed/Persistent Hematologic Malignancies After Allogeneic Stem Cell Transplantation
Status: WITHDRAWN
Conditions: Acute Myeloid Leukemia|Acute Lymphoid Leukemia|Myelodysplastic Syndromes|Myeloproliferative Disorders|Chronic Myeloid Leukemia|Myelofibrosis|Multiple Myeloma|Malignant Lymphoma
Interventions: DRUG: MDG1021 dose 1|DRUG: MDG1021 dose 2|DRUG: MDG1021 dose 3|DRUG: MDG1021 optimal dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Sphincterotomy With Balloon Dilatation Versus Sphincterotomy Alone For Common Bile Duct Stones Removal
Status: COMPLETED
Conditions: Choledocholithiasis
Interventions: PROCEDURE: endoscopic sphincterotomy (EST) versus EST plus endoscopic papillary large balloon dilatation (EPLBD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 Compared With Intravitreal Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD)
Status: COMPLETED
Conditions: Wet Age-related Macular Degeneration
Interventions: DRUG: KSI-301|DRUG: Aflibercept|OTHER: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraventricular Stasis in Non Ischemic Dilated Myocardiopathy
Status: COMPLETED
Conditions: Dilated Cardiomyopathy|Thrombosis|Stroke
Interventions: DIAGNOSTIC_TEST: Doppler echocardiogram exam|DIAGNOSTIC_TEST: Cardiac Magnetic Resonance|DIAGNOSTIC_TEST: Brain Magnetic Resonance|DIAGNOSTIC_TEST: Coagulation blood test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study of Exenatide Pharmacokinetics and Pharmacodynamics in Gestational Diabetes
Status: WITHDRAWN
Conditions: Gestational Diabetes
Interventions: DRUG: Exenatide|GENETIC: Buccal/blood Sample Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy of SMOF Lipid in the Management of Acute Poisoning With Clozapine
Status: COMPLETED
Conditions: Acute Poisoning
Interventions: OTHER: SMOF lipid 20%|OTHER: standard treatment for clozapine toxicity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phosphodiesterase Type 5 Inhibition With Tadalafil Changes Outcomes in Heart Failure
Status: TERMINATED
Conditions: Heart Failure|Pulmonary Hypertension
Interventions: DRUG: Tadalafil|DRUG: Placebo for tadalafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Educational Interventions on Diabetic Foot Care
Status: COMPLETED
Conditions: Diabetes Mellitus|Diabetic Foot
Interventions: BEHAVIORAL: Instructive video on diabetic foot care|BEHAVIORAL: Informative leaflet with real-time guided reading|BEHAVIORAL: Informative leaflet to read at home|BEHAVIORAL: Face-to-face teaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Different Treatment Regimens With Chitosan-N- Acetylcysteine in Moderate-to-severe Dry Eye Disease
Status: TERMINATED
Conditions: Eye Diseases
Interventions: DEVICE: Lacrimera|DEVICE: Hylo-Vision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Computer Driven Management of Weaning Following Prolonged Mechanical Ventilation
Status: UNKNOWN
Conditions: Mechanical Ventilation|Weaning|Prolonged Ventilation
Interventions: PROCEDURE: Closed-loop sytem for5 weaning from mechanical ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nitrofurantoin Administration for the Prevention of Short-Term Catheter Associated Urinary Tract Infection After Pelvic Surgery
Status: COMPLETED
Conditions: Catheter-Associated Urinary Tract Infection
Interventions: DRUG: Nitrofurantoin 100 MG|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study to Evaluate the Visual Performance of Three Multifocal IOLs
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: Trifocal Intraocular Lens|DEVICE: Bifocal Intraocular Lens|DEVICE: Low Addition Bifocal Intraocular Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of TPX-105 for Correction of Nasojugal Groove
Status: COMPLETED
Conditions: Tear Trough Eyelid Deformity
Interventions: BIOLOGICAL: TPX-105|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Community-Acquired Pneumonia : Evaluation of Corticosteroids
Status: COMPLETED
Conditions: Community Acquired Pneumonia
Interventions: DRUG: Hydrocortisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 4D-flow Cardiac MRI to Assess Pulmonary Arterial Pressure in Pulmonary Hypertension
Status: COMPLETED
Conditions: Pulmonary Hypertension|Magnetic Resonance Imaging|Pulmonary Arterial Pressure|Right Heart Catheterization|Echocardiography
Interventions: OTHER: 4D-flow sequence
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Dimensional Changes After Tooth Extractions Between Xenograft and Allograft
Status: ACTIVE_NOT_RECRUITING
Conditions: Tooth Loss
Interventions: DEVICE: Bone graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phone Enabled Implementation of Cessation Support (PHOENICS)
Status: RECRUITING
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Educational materials|BEHAVIORAL: Phone counseling|DRUG: Nicotine Replacement Therapy|BEHAVIORAL: Provider training|BEHAVIORAL: Electronic reminders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: PyloPlus Urea Breath Test System Post Therapy Efficacy Confirmation Study
Status: RECRUITING
Conditions: Helicobacter Pylori Infection|Post-Treatment|Efficacy
Interventions: COMBINATION_PRODUCT: PyloPlus UBT System|DIAGNOSTIC_TEST: Histology|DIAGNOSTIC_TEST: Rapid Urease Test|COMBINATION_PRODUCT: Comparator Breath Test|DIAGNOSTIC_TEST: Stool Antigen Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Shorter Course Tacrolimus After Nonmyeloablative, Related Donor BMT With High-dose Posttransplantation Cyclophosphamide
Status: COMPLETED
Conditions: Hodgkin's Lymphoma|Leukemia|Myelodysplastic Syndrome(MDS)|Multiple Myeloma|Non Hodgkin's Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|RADIATION: Total body irradiation|DRUG: Mycophenolate Mofetil|DRUG: Tacrolimus 60|DRUG: Tacrolimus 90|DRUG: Tacrolimus 120|BIOLOGICAL: Bone marrow transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aripiprazole in Children and Adolescents With Chronic Tic Disorder or Tourette's Disorder
Status: COMPLETED
Conditions: Chronic Motor or Vocal Tic Disorder|Tourette's Disorder
Interventions: DRUG: aripiprazole|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carotid Artery Implant for Trapping Upstream Emboli for Preventing Stroke in Atrial Fibrillation Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: Vine™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cortisol Response to Adrenocorticotrophin (ACTH) in Acute Stress
Status: UNKNOWN
Conditions: Aortic Aneurysm, Abdominal
Interventions: DRUG: Adrenocorticotrophic hormone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Corrections Work's Adverse Effects and a Total Worker Health Program to Enhance Well-being
Status: RECRUITING
Conditions: Occupational Stress|Health Behavior|Safety Issues|Mental Health Wellness 1
Interventions: BEHAVIORAL: Total Worker Health Mindfulness Enhanced Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, and Efficacy Study of LFX453 in Actinic Keratosis Patients
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Investigational Treatment|DRUG: Active comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT