pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study in Participants Previously Enrolled in a Genentech- and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study (IMbrella A)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer
Interventions: DRUG: Atezolizumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Modes of Telehealth Delivery: Phone vs. Video Visits (ASSIST)
Status: COMPLETED
Conditions: Rheumatic Disease|Cardiac Disease|Primary Care|Infectious Disease
Interventions: OTHER: Phone Visit|OTHER: Video Visit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Acetaminophen Adduct Formation in Non-Drinkers Taking Therapeutic Doses of Acetaminophen for Ten Consecutive Days
Status: COMPLETED
Conditions: Drug Induced Liver Injury
Interventions: DRUG: acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Bioequivalence Study for Ondansetron Hydrochloride Tablets 8 mg Under Fed Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ondansetron Hydrochloride|DRUG: Ondansetron Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Engaging Staff to Improve COVID-19 Vaccination Response at Long-Term Care Facilities
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BEHAVIORAL: Full Intervention|OTHER: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Utidelone Plus Capecitabine Versus Taxane Plus Capecitabine in HER2-negative Locally Advanced or Metastatic Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Neoplasms|Locally Advanced or Metastatic Breast Cancer
Interventions: DRUG: Taxane plus Intermittent Capecitabine|DRUG: Utidelone plus Intermittent Capecitabine|DRUG: Taxane plus Metronomic Capecitabine|DRUG: Utidelone plus Metronomic Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long-Term Extension Study for Participants With Treatment-resistant Major Depressive Disorder Who Are Continuing Esketamine Nasal Spray Treatment
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Esketamine|DRUG: SSRI/SNRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Motivational Interviews Conducted Through Tele-Nursing on Diabetes Management
Status: ENROLLING_BY_INVITATION
Conditions: Type 1 Diabetes|Motivational Interviewing
Interventions: OTHER: Education and Motivational Interviews
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of HGS1029 in Subjects With Relapsed or Refractory Lymphoid Malignancies
Status: TERMINATED
Conditions: Lymphoid Malignancies
Interventions: DRUG: HGS1029
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Register Study: Implementation of Pharyngeal Electrostimulation Therapy for the Treatment of Acute Neurogenic Dysphagia
Status: RECRUITING
Conditions: Neurogenic Dysphagia|Traumatic Brain Injury|Stroke|Dysphagia|Long Covid-19|Intubation Complication|Polyradiculitis
Interventions: DEVICE: Pharyngeal electrostimulation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders
Status: RECRUITING
Conditions: Substance Use Disorders|Opioid Use Disorder|Alcohol Use Disorder|Cocaine Use Disorder|Methamphetamine-dependence
Interventions: COMBINATION_PRODUCT: EDITOR (CBOT with olfactory stimulants, OFC tasks & remote monitoring of treatment compliance)|COMBINATION_PRODUCT: CBOT with olfactory stimulants & OFC tasks|COMBINATION_PRODUCT: CBOT Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-Guided Thermocoagulation of Medial Nerve Branch in Lumbar Facet Joints Pain.
Status: UNKNOWN
Conditions: Low Back Pain|Facet Joint Pain|Facet Syndrome of Lumbar Spine|Chronic Low Back Pain
Interventions: PROCEDURE: Ultrasound-Guided Thermocoagulation of Lumbar facet joints|PROCEDURE: Fluoroscopy-Guided Thermocoagulation of Lumbar facet joints
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Randomized Clinical Trial of Luminate® as Compared to Avastin® in the Treatment of Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Luminate 1.0mg|DRUG: Luminate 2.0mg|DRUG: Luminate 3.0mg|DRUG: Avastin|DRUG: Luminate 0.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Nivolumab in Patients With Advanced Refractory Biliary Tract Cancers
Status: COMPLETED
Conditions: Biliary Tract Cancer|Biliary Tract Neoplasms
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety,Tolerability and Efficacy of PF-04360365 in Adults With Probable Cerebral Amyloid Angiopathy
Status: COMPLETED
Conditions: Cerebral Amyloid Angiopathy
Interventions: BIOLOGICAL: Ponezumab|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Life Satisfaction and Psychopathology in Institutionalized Elderly People
Status: COMPLETED
Conditions: Anxiety Depression (Mild or Not Persistent)
Interventions: BEHAVIORAL: Mindfulness-Based Stress Reduction (MBSR) program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy Study on the Implantation of the Tension-Free Vaginal Tape (TVT-Secur) Under Local Anesthesia
Status: COMPLETED
Conditions: Urinary Stress Incontinence
Interventions: PROCEDURE: TVT-SECUR - 'Hammock' technique|PROCEDURE: TVT-SECUR - 'U-Method'|DRUG: Local anesthesia (30 to 40 ml of a mixture of 35 ml of lidocaine 2% and 5 ml of bicarbonate 3%).
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination With Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis After Reduced Intensity Conditioning and Peripheral Blood Stem Cell Transplantation
Status: RECRUITING
Conditions: Peripheral Blood Stem Cell Transplantation|Hematopoietic Stem Cell Transplantation
Interventions: DRUG: Melphalan|DRUG: Sirolimus|RADIATION: Total Body Irradiation (TBI)|DRUG: Cyclophosphamide|DRUG: Mycophenolate Mofeti|DRUG: Fludarabine|PROCEDURE: Allogeneic HSCT|DRUG: Mesna|DRUG: Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 99mTc Sestamibi Scans In Thyroglobulin Positive Scan Negative Differentiated Thyroid Cancer (DTC) Patients
Status: TERMINATED
Conditions: Thyroid Cancer
Interventions: DRUG: 99mTc sestamibi
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Active Breathing Exercises in Stroke Patients With Respiratory Rhythm Disorder
Status: RECRUITING
Conditions: Respiratory Rhythm Disorder
Interventions: BEHAVIORAL: Rehabilitation training|BEHAVIORAL: Active Breathing Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of a Mixed Macronutritional Meal With Medium Chain Triglycerides on the Oxidation of Postprandial Macronutrients
Status: UNKNOWN
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Mixed meal with medium chain triglycerides|DIETARY_SUPPLEMENT: Mixed meal with the replacement of medium chain triglycerides with unsaturated tryglicerides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Transdermal Nicotine on Smoking, Craving and Withdrawal in People With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia and Disorders With Psychotic Features|Tobacco Use Disorder|Schizophrenia
Interventions: DRUG: Transdermal Nicotine Patch|DRUG: 21 mg transdermal nicotine|DRUG: placebo patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Comparison of Surgical and a New Non-Surgical Treatment Methods for Secretory Otitis Media in Children
Status: UNKNOWN
Conditions: Secretory Otitis Media
Interventions: DEVICE: Moniri Otovent|DEVICE: Tympanostomy tube in the ear drum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preloading Magnesium Attenuate Cisplatin-induced Nephrotoxicity
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: DRUG: Magnesium|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Coronary Flow and Myocardial Viability: the FloVITA Study
Status: RECRUITING
Conditions: Myocardial Infarction|Myocardial Ischemia
Interventions: DEVICE: Absolute coronary flow measurement|DEVICE: Microvascular resistance measurement|OTHER: Cardiac MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ultrasound-Guided Intermediate Versus Deep Cervical Plexus Block for Carotid Endarterectomy
Status: COMPLETED
Conditions: Anesthesia
Interventions: PROCEDURE: Intermediate cervical plexus block|PROCEDURE: Deep cervical plexus block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NICardipine Neuroprotection in AortiC Surgery (NICNACS)
Status: TERMINATED
Conditions: Aortic Aneurysm, Thoracic
Interventions: DRUG: Nicardipine|DRUG: 0.9% saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Romidepsin, Gemcitabine, Oxaliplatin, and Dexamethasone in Patients With Relapsed/Refractory Aggressive Lymphomas
Status: COMPLETED
Conditions: Lymphoma, T-Cell, Cutaneous|Lymphoma, T-Cell, Peripheral|Hodgkin Disease|Lymphoma, Large B-Cell, Diffuse
Interventions: DRUG: Romidepsin|DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Dexamethasone|DRUG: Pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sintilimab and Apatinib Combined Chemotherapy in Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Sintilimab+Apatinib+Albumin-Bound Paclitaxel(Nab-Paclitaxel)+Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Home-based NMES Therapy for Knee Osteoarthritis Pain
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: CyMedica e-vive NMES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-Density Lipoprotein (HDL) Cholesterol Increased Plaque Stabilization in the Elderly
Status: COMPLETED
Conditions: Atherosclerosis|Cardiovascular Disease
Interventions: DRUG: any statin|DRUG: niacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of MK-2206 in Combination With Standard Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors (MK-2206-003)
Status: COMPLETED
Conditions: Locally Advanced, Metastatic Solid Tumors
Interventions: DRUG: MK-2206|DRUG: docetaxel|DRUG: erlotinib|DRUG: carboplatin|DRUG: paclitaxel|DRUG: corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ASC930 in Patients With Steroid-Refractory Acute Graft Versus Host Disease (SR-aGVHD)
Status: NOT_YET_RECRUITING
Conditions: Acute-graft-versus-host Disease
Interventions: BIOLOGICAL: ASC930
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oral Azelaprag Plus Once Weekly Tirzepatide Compared With Tirzepatide Alone in Participants With Obesity Aged 55 Years and Over
Status: RECRUITING
Conditions: Obesity
Interventions: DRUG: Oral Azelaprag (BGE-105)|DRUG: Oral Placebo for Azelaprag (BGE-105)|DRUG: Tirzepatide|DRUG: Tirzepatide Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combining Varenicline and Bupropion for Smoking Cessation
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Varenicline|DRUG: Bupropion|OTHER: Placebo|BEHAVIORAL: Counseling/Phone Calls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Triplet (FOLFOXIRI) vs. Doublet (FOLFOX or FOLFIRI) Regimen as a 1st Line Treatment in Metastatic Colorectal Carcinoma
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: FOLFOXIRI Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Perineorraphy Versus Pelvic Floor Exercise - a Randomized Trial
Status: UNKNOWN
Conditions: Perineal Tear Resulting From Childbirth
Interventions: PROCEDURE: Perineorraphy|OTHER: Pelvic floor exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety and Pharmacology of Atezolizumab Administered in Combination With Immunomodulatory Agents in Participants With Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Atezolizumab|DRUG: Guadecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Single-center, Double-blind, Placebo-controlled Study of TNP-2092 Capsules, and the Food Effect Study After Single-dose Oral Administration of TNP-2092 Capsules
Status: COMPLETED
Conditions: Hyperammonemia
Interventions: DRUG: TNP-2092|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Increasing the Variety of Vegetables and Fruits Served to Preschool Children at a Snack
Status: COMPLETED
Conditions: Obesity|Feeding Behaviors
Interventions: OTHER: Cucumber snack|OTHER: Pepper snack|OTHER: Tomato snack|OTHER: Vegetable variety snack|OTHER: Apple snack|OTHER: Peach snack|OTHER: Pineapple snack|OTHER: Fruit variety snack
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Study to Evaluate Sotagliflozin in Subjects With Varying Degrees of Renal Function
Status: COMPLETED
Conditions: Renal Impairment|Healthy
Interventions: DRUG: Sotagliflozin|DRUG: Sotagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of MEDI 507 in the Treatment of Pediatric Patients
Status: COMPLETED
Conditions: Graft Versus Host Disease
Interventions: DRUG: MEDI-507|DRUG: MEDI-507|DRUG: MEDI-507
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A BE Study Comparing Mesalamine 400 mg to ASACOL® 400 mg in Patients With Mild To Moderately Active Ulcerative Colitis
Status: COMPLETED
Conditions: Mild to Moderate Ulcerative Colitis
Interventions: DRUG: Placebo|DRUG: Mesalamine|DRUG: Mesalamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose:
Clinical trial: Gait-based Evaluation of Early Rehabilitation After ACL Reconstruction
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament Reconstruction
Interventions: PROCEDURE: Home-based therapy after ACL reconstruction|PROCEDURE: Standardized ambulant therapy after ACL reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CANnabiDiol for CoviD-19 pATiEnts With Mild to Moderate Symptoms
Status: UNKNOWN
Conditions: SARS-CoV2
Interventions: DRUG: Cannabidiol|OTHER: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Back up Head Elevated Position on Laryngeal Visualization.
Status: UNKNOWN
Conditions: Intubation;Difficult
Interventions: PROCEDURE: back up head elevated position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Intensive Dietary Intervention in Children With Birth Weight Between 1500 and 2000 g
Status: UNKNOWN
Conditions: Perinatal Disorders of Growth and Development
Interventions: DIETARY_SUPPLEMENT: CAKE-intervention|DIETARY_SUPPLEMENT: CAKE-control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Alveolar Recruitment Maneuver on Postoperative Pain
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: PROCEDURE: Alveolar recruitment maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Medication and Counseling for Controlled Drinking (Project SMART)
Status: COMPLETED
Conditions: Alcohol-related Disorders|Alcohol Drinking|Alcoholism|Alcohol Abuse
Interventions: DRUG: Naltrexone|BEHAVIORAL: Modified Behavioral Self-Control Psychotherapy|BEHAVIORAL: Brief Behavioral Compliance Enhancement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise and Sauna on Blood Pressure and Cardiovascular Health
Status: COMPLETED
Conditions: Cardiovascular Risk Factor|Heat Stress|Sedentary Behavior
Interventions: OTHER: Exercise|OTHER: Sauna
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Mindfulness-Based Web-Based Stress Reduction Program Applied to Primigravidas on Perceived Stress Level in Pregnancy, Birth Self-Efficacy and Prenatal Attachment
Status: NOT_YET_RECRUITING
Conditions: Pregnancy Related
Interventions: OTHER: mindfulness group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: KPL-301 for Subjects With Giant Cell Arteritis
Status: COMPLETED
Conditions: Giant Cell Arteritis
Interventions: COMBINATION_PRODUCT: mavrilimumab|COMBINATION_PRODUCT: placebo|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DS-1205c With Gefitinib for Metastatic or Unresectable Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: DS-1205c|DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Intrapulmonary Percussive Ventilator on Respiratory Function
Status: NOT_YET_RECRUITING
Conditions: Airway Clearance Impairment
Interventions: DEVICE: Intrapulmonary Percussive ventilator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A First-in-human Study of 3HP-2827 in Patients With Unresectable or Metastatic Solid Tumors With FGFR2 Alterations
Status: NOT_YET_RECRUITING
Conditions: Solid Tumors With FGFR2 Alterations, Adult
Interventions: DRUG: 3HP-2827
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Prediction of Sepsis
Status: COMPLETED
Conditions: Sepsis
Interventions: DEVICE: Unblinded AlgoDx Sepsis Prediction Algorithm|OTHER: Blinded AlgoDx Sepsis Prediction Algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Endostar + GT in Pulmonary Metastases of Soft Tissue Sarcoma
Status: UNKNOWN
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: Endostar|DRUG: Gemcitabine|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SU5416 and Irinotecan in Treating Patients With Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Colon|Adenocarcinoma of the Rectum|Recurrent Colon Cancer|Recurrent Rectal Cancer|Stage III Colon Cancer|Stage III Rectal Cancer|Stage IV Colon Cancer|Stage IV Rectal Cancer
Interventions: DRUG: irinotecan hydrochloride|DRUG: semaxanib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Short-Term Anti-HIV Drug Therapy for Recent HIV-1 Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Tenofovir disoproxil fumarate/Emtricitabine|DRUG: Lopinavir/Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Echinacea, Propolis and Vitamin C for URI Prevention in Preschoolers
Status: COMPLETED
Conditions: Common Cold|Gastroenteritis
Interventions: DRUG: dietary supplement--echinacea, propolis, and vitamin c
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Assessment of the Efficacy of Letrozole in the Treatment of Ectopic Pregnancy
Status: ACTIVE_NOT_RECRUITING
Conditions: Ectopic Pregnancy
Interventions: DRUG: Letrozole|DRUG: methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study in Healthy Male Volunteers to Compare the Bioequivalence of Fixed Dose Combination of Eperisone Hydrochloride 50mg Plus Diclofenac Sodium 50mg as Capsule With Eperisone Hydrochloride 50mg and Diclofenac Sodium 50mg Tablets Under Fasting Conditions (Study 013-10)
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: eperisone hydrochloride plus diclofenac sodium capsule|DRUG: eperisone hydrochloride tablet and diclofenac sodium tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GnRH Agonist Triggering Supplemented With Hcg in Women With Poor Ovarian Response
Status: UNKNOWN
Conditions: Women With Poor Ovarian Response
Interventions: DRUG: Ovitrel|DRUG: Decapeptyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Partial Oxygen and Carbon Dioxide Pressures Compared With Blood Gas Values
Status: COMPLETED
Conditions: Critical Illness
Interventions: DEVICE: Sentec (SenTec) Digital Monitoring System with OxiVenT Sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neoadjuvant Study of Pyrotinib and Trastuzumab Plus Chemotherapy in Patients With HER2 Positive Breast Cancer
Status: UNKNOWN
Conditions: HER2-positive Breast Cancer
Interventions: DRUG: Pyrotinib+Trastuzumab+Docetaxel+Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-individual Real Life Effects of Cocoa Flavanols on Blood Pressure and Arterial Stiffness
Status: COMPLETED
Conditions: Blood Pressure|Stiffness, Vascular|Sleep
Interventions: DIETARY_SUPPLEMENT: Cocoa flavanol (CF)|OTHER: Placebo (P)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: COMPARATIVE STUDY OF THE EFFICACY OF HYALURONIC ACID, DRY NEEDLING AND COMBINED TREATMENT IN PATELLAR OSTEOARTHRITIS
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: dry needling|OTHER: ultrasound|DEVICE: hyauluronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Nasopharyngeal Swab v. Nasopharyngeal Saline Wash or Saliva Collection in Testing for Respiratory Viruses
Status: RECRUITING
Conditions: Respiratory Tract Infections
Interventions: DIAGNOSTIC_TEST: Respiratory pathogen panel PCR test|DIAGNOSTIC_TEST: COVID-19 antibody test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Determination of Predictive Clinical Signs of Effective Rhizolysis Using the DFL Questionnaire.
Status: UNKNOWN
Conditions: Rhizolysis|Diagnosis of Facet Joint Origin Lumbago
Interventions: OTHER: Rhizolysis pain analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Sildenafil in Preterm Infants With Evolving Chronic Lung Disease
Status: COMPLETED
Conditions: Lung Diseases
Interventions: DRUG: Sildenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nitric Oxide Administration During Pediatric Cardiopulmonary Bypass Surgery to Prevent Platelet Activation
Status: COMPLETED
Conditions: Inflammation|Platelet Dysfunction
Interventions: DRUG: Nitric Oxide|DRUG: Placebo|DEVICE: INOmax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Pembrolizumab (MK-3475) Combined With Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Advanced Melanoma (MK-7902-003/E7080-G000-312/LEAP-003)-China Extension Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Melanoma
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Lenvatinib|DRUG: Placebo for lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety, Tolerability and Immunogenicity Study of GLS-5300 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: GLS-5300|DEVICE: Cellectra 2000 Electroporation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Patients With Fecal Incontinence
Status: TERMINATED
Conditions: Fecal Incontinence
Interventions: BEHAVIORAL: Biofeedback Therapy for Fecal Incontinence: A Randomized Control Study|BEHAVIORAL: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: to Evaluate the Efficacy and Safety of Eltrombopag for Immune Thrombocytopenia With Chronic HBV Infection
Status: COMPLETED
Conditions: Thrombocytopenia Purpura|Chronic HBV Infection
Interventions: DRUG: Eltrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Dose PK of IV Tedizolid Phosphate in Morbidly Obese and Non-Obese Adults
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Tedizolid phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase 2a Study of AR882 Alone and in Combination With Febuxostat or Allopurinol in Gout Patients
Status: COMPLETED
Conditions: Gout Patients
Interventions: DRUG: Group 1: AR882 Alone and in Combination with Febuxostat (FBX)|DRUG: Group 2: AR882 Alone and in Combination with Allopurinol (ALLO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy Plus Immune Adjuvant in Treating Patients With Chronic Myeloid Leukemia, Acute Myeloid Leukemia, or Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Accelerated Phase Chronic Myelogenous Leukemia|Adult Acute Myeloid Leukemia in Remission|Chronic Phase Chronic Myelogenous Leukemia|Previously Treated Myelodysplastic Syndromes|Refractory Anemia With Excess Blasts|Refractory Anemia With Excess Blasts in Transformation|Relapsing Chronic Myelogenous Leukemia
Interventions: BIOLOGICAL: PR1 leukemia peptide vaccine|DRUG: Montanide ISA 51 VG|BIOLOGICAL: sargramostim|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopist and Endoscope Motions During Colonoscopy
Status: COMPLETED
Conditions: Intestinal Disease|Colonic Diseases
Interventions: PROCEDURE: Recording of endoscopist and endoscope motions right after the endoscopic exam the patient came for
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Two Cycles Versus Three Cyclle of CCRT for Low Risk Locoregionally Advanced Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Cisplatin combine with IMRT|DRUG: Cisplatin combine with IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fotemustine in Treating Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: DRUG: fotemustine|GENETIC: gene expression analysis|GENETIC: polymerase chain reaction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Sentinel Lymph Node Biopsy in Early-Stage Ovarian Cancer
Status: RECRUITING
Conditions: Sentinel Lymph Node|Ovarian Carcinoma
Interventions: DIAGNOSTIC_TEST: Sentinel lymph node biopsy (using sterile charcoal stain) in early ovarian cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase 3 Study to Evaluate Safety and Efficacy of Iclaprim Versus Vancomycin for ABSSSI: REVIVE-2
Status: COMPLETED
Conditions: Skin Structures and Soft Tissue Infections
Interventions: DRUG: Iclaprim|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Benefit and Tolerability of WAK2017 on Endothelial Function, Blood Pressure and Lipid Profile
Status: UNKNOWN
Conditions: Endothelial Function|Blood Pressure|Lipid Metabolism
Interventions: DIETARY_SUPPLEMENT: WAK2017|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Toothpaste Containing Zinc Lactate as Compared to Colgate Cavity Protection Toothpaste.
Status: COMPLETED
Conditions: Gingivitis|Plaque
Interventions: DRUG: Meridol|DRUG: Colgate Cavity Protection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EVALUATION OF THE SAFETY AND EFFICACY OF ADJUSTABLE CONTINENCE THERAPY BALLOONS IN BLADDER EXSTROPHY AND INCONTINENT EPISPADIAS PATIENTS
Status: RECRUITING
Conditions: Bladder Exstrophy
Interventions: DEVICE: ACT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STEP: Study of Imaging Techniques (ImaTx and DXA) in Postmenopausal Women With OstEoporosis Using Preotact (FP-008-ES)
Status: COMPLETED
Conditions: Postmenopausal Women With Primary Osteoporosis
Interventions: DRUG: Parathyroid hormone (PTH)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Patient-Centered Program for Low Anterior Resection Syndrome A Multicenter Randomized Controlled Trial
Status: UNKNOWN
Conditions: Rectal Cancer|Surgery|Patient Activation|Low Anterior Resection|Low Anterior Resection Syndrome
Interventions: OTHER: Patient Activation Booklet and nursing support for patients with LARS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intraperitoneal MCY-M11 (Mesothelin-targeting CAR) for Treatment of Advanced Ovarian Cancer and Peritoneal Mesothelioma
Status: TERMINATED
Conditions: Peritoneal Mesothelioma|Fallopian Tube Adenocarcinoma|Adenocarcinoma of the Ovary|Primary Peritoneal Carcinoma
Interventions: BIOLOGICAL: MCY-M11|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Pharmacological Effect and Plasma Concentration of ASP7991 After Single Oral Administration to Healthy Volunteers
Status: COMPLETED
Conditions: Healthy|Pharmacokinetics of ASP7991
Interventions: DRUG: ASP7991|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: The Feasibility, Safety, and Efficacy of Not Indwelling of Ureteral Stents in Percutaneous Nephrolithotomy
Status: COMPLETED
Conditions: Urolithiasis
Interventions: PROCEDURE: not Indwelling the ureteral stent|PROCEDURE: Indwelling the ureteral stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outpatient Cervical Ripening With Orally Administered Misoprostol in Diabetics
Status: TERMINATED
Conditions: Diabetes, Gestational
Interventions: DRUG: Misoprostol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Three Irrigants, Sodium Hypochlorite, Chlorhexidine and Combination of CHX+H2O2 in Endodontic Treatment.
Status: UNKNOWN
Conditions: Periapical Periodontitis
Interventions: PROCEDURE: Sodium hypochlorite|PROCEDURE: Chlorhexidine|PROCEDURE: Chlorhexidine + Hydrogen peroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ACCULINK for Revascularization of Carotids in High Risk Patients "The ARCHeR Trial"
Status: COMPLETED
Conditions: Carotid Atherosclerosis|Carotid Artery Disease
Interventions: DEVICE: Over-the-wire & Rapid Exchange ACCULINK (tm) Carotid Stent & ACCUNET (tm) embolic protection system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Rectal Safety Study of Three Tenofovir Gel Formulations
Status: COMPLETED
Conditions: HIV Prevention
Interventions: DRUG: Rectal formulation (RF) of tenofovir 1% gel|DRUG: Vaginal formulation (VF) of tenofovir 1% gel|DRUG: Reduced glycerin vaginal formulation (RGVF) of tenofovir 1% gel|RADIATION: Radiolabeling of study drugs and semen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Dose Escalation and Cohort Expansion Study of Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab) in Advanced Refractory Solid Tumors
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck (SCCHN)|Ovarian Carcinoma-Enrollment Completed|Colorectal Cancer (CRC)-Enrollment Completed|Renal Cell Carcinoma (RCC) (Phase ll Only)|Glioblastoma (GBM) (Phase ll Only)-Enrollment Completed
Interventions: DRUG: Combination of varlilumab and nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab With DA-REPOCH Chemotherapy Regimen in Treating Patients With Aggressive B-Cell Non-Hodgkin's Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Aggressive Non-Hodgkin Lymphoma|Ann Arbor Stage I Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma|Ann Arbor Stage II B-Cell Non-Hodgkin Lymphoma|Ann Arbor Stage II Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma|Ann Arbor Stage III B-Cell Non-Hodgkin Lymphoma|Ann Arbor Stage III Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma|Ann Arbor Stage IV B-Cell Non-Hodgkin Lymphoma|Ann Arbor Stage IV Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma|Diffuse Large B-Cell Lymphoma|High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements|High Grade B-Cell Lymphoma, Not Otherwise Specified|Indolent Non-Hodgkin Lymphoma|Mediastinal B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma|Transformed Non-Hodgkin Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Doxorubicin Hydrochloride|DRUG: Etoposide|BIOLOGICAL: Nivolumab|DRUG: Prednisone|BIOLOGICAL: Rituximab|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MaxART: Early Access to ART for All in Swaziland
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: OTHER: Early Access to ART for All
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Health-economic Impact of Pulse Oximetry Systematic Screening of Critical Congenital Heart Disease in Asymptomatic Newborns
Status: COMPLETED
Conditions: Critical Congenital Heart Disease
Interventions: DIAGNOSTIC_TEST: Pulse oximetry
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: 12-Week Efficacy and Safety Study of Ibodutant in Women With Irritable Bowel Syndrome With Diarrhea (IBS-D)
Status: WITHDRAWN
Conditions: Irritable Bowel Syndrome With Diarrhea
Interventions: DRUG: Ibodutant 10 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Randomized Controlled Study of Interventional Treatment for Operable Stage Ⅱ-Ⅲ Non-small Cell Lung Cancer With Potential Recurrence as Minimal Residual Disease(MRD) Positive
Status: NOT_YET_RECRUITING
Conditions: DFS
Interventions: DRUG: Chemotherapy combined with immunization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Functional Electrical Stimulation on Gait in Children With Cerebral Palsy
Status: UNKNOWN
Conditions: Cerebral Palsy, Congenital|Muscle Spasticity
Interventions: DEVICE: WalkAide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PERL Continuous Glucose Monitoring (CGM) Study
Status: COMPLETED
Conditions: Diabetic Nephropathies
Interventions: OTHER: Mean blood glucose|OTHER: Blood glucose CV|OTHER: % time 70-180 mg/dL|OTHER: % time below 54 mg/dL|OTHER: % time above 180 mg/dL|OTHER: % time above 250 mg/dL|OTHER: MAGE (Mean amplitude of glucose excursions)|OTHER: LBGI (Low Blood Glucose Index)|OTHER: HBGI (High Blood Glucose Index)|DRUG: Allopurinol|DRUG: Placebo
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Study of Ingavirin® to Treat Influenza and Other Acute Respiratory Viral Infections in Patients 3-6 y.o.
Status: COMPLETED
Conditions: Common Cold|Influenza
Interventions: DRUG: Imidazolyl ethanamide pentandioic acid|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Riluzole Augmentation in Treatment-refractory Obsessive-compulsive Disorder
Status: COMPLETED
Conditions: Obsessive-compulsive Disorder|Ocd
Interventions: DRUG: riluzole|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Development of Sleep-wake Cycles in Premature Infants and Its Impact on Neurodevelopmental Outcome
Status: UNKNOWN
Conditions: Sleep Disorders, Circadian Rhythm
Interventions: OTHER: aEEG and conventional EEG measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Far Infrared Radiation Treatment for Uterine Fibroids
Status: UNKNOWN
Conditions: Leiomyoma
Interventions: RADIATION: Far Infrared Radiation (5μm to 20μm wavelength)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Window-of-opportunity Study of Pelareorep in Early Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: Pelareorep|DRUG: Letrozole|DRUG: Atezolizumab|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervening to Repair Cognitive and Behavioural Problems in Adults Exposed to Childhood Malnutrition
Status: UNKNOWN
Conditions: Severe Acute Malnutrition|Cognitive Impairment|Emotional Disturbances
Interventions: COMBINATION_PRODUCT: Exercise plus omega-3 supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of tACS on the Recovery of Motor Control of the Upper Limb and Cerebral Connectivity in Chronic Stroke Patients
Status: RECRUITING
Conditions: Chronic Stroke|Rehabilitation
Interventions: DEVICE: transcranial alternating current stimulation 70 Hz|BEHAVIORAL: Training|DEVICE: transcranial alternating current stimulation 7 Hz|DEVICE: transcranial alternating current stimulation Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Lixisenatide on Postprandial Glucose Tolerance in Pancreatectomised Subjects
Status: COMPLETED
Conditions: Diabetes After Total Pancreatectomy
Interventions: DRUG: Lixisenatide|DRUG: Lixisenatide-Placebo|OTHER: Standardized liquid meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Replacing HFCS With Sucromalt in Subjects With Raised Waist Circumference
Status: COMPLETED
Conditions: Abdominal Obesity
Interventions: DRUG: High Fructose Corn Syrup|DRUG: Sucromalt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study Examining the Pharmacokinetics and Tolerability of a Single Oral Dose of Bendavia (MTP-131)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Bendavia 10mg|DRUG: Bendavia 50mg|DRUG: Bendavia 100mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE