pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: AqueSys XEN 45 Glaucoma Implant in Refractory Glaucoma
Status: COMPLETED
Conditions: Glaucoma|Glaucoma, Open Angle
Interventions: DEVICE: AqueSys XEN 45 Glaucoma Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavior Therapy (CBT)-Based Group Intervention to Reduce Inflammation in Older People With HIV
Status: ACTIVE_NOT_RECRUITING
Conditions: Aging|HIV
Interventions: BEHAVIORAL: Weekly Group Skills|OTHER: One-time Trifold Brochure titled "HIV: 50 Years or Older"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Radomised Phase II Study of MTL-CEBPA Plus Sorafenib or Sorafenib Alone
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma|Hepatitis B|Hepatitis C
Interventions: DRUG: MTL-CEBPA|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-Mesh Versus Mesh Method for Inguinal Hernia Repair
Status: UNKNOWN
Conditions: Hernia, Inguinal
Interventions: PROCEDURE: Non-mesh Hernia Repair|PROCEDURE: Mesh Hernia Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrated Exercise Approach Strength Postural Stability Menstrual Cycle Biomarkers Eumenorrheic Females
Status: COMPLETED
Conditions: Females|Menstrual Discomfort
Interventions: OTHER: integrated exercise approach|OTHER: educational program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: This is a 2 Year Follow up Clinical and Radiographic Analysis of a Novel All Polyethelene Glenoid Component in Standard Total Shoulder Arthroplasty.
Status: UNKNOWN
Conditions: The Primary Disease Process Being Studied is Shoulder OA and the Effect of an All Polyethelene Glenoid Component on Shoulder Arthroplasty
Interventions: DEVICE: Shoulder arthroplasty with anchor peg glenoid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimizing Risk and Maximizing Outcomes in Geriatric Patients Through Integrated Clinical Pharmacy Services in an Innovative Model of Community Practice
Status: COMPLETED
Conditions: Medication Adherence|Health Literacy|Geriatric Patient Care Improvement|Pharmacy Economic Improvement
Interventions: BEHAVIORAL: Medication adherence consultation|OTHER: Medication problems assessment|OTHER: Beer's Criteria Assessment|BEHAVIORAL: Health Literacy Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Rapid Stress/Rest Single-Day Tc-99m Sestamibi Myocardial Single Photon Emission Computed Tomography
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: OTHER: low-dose stress MPI SPECT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetics of Midazolam, Dabigatran, Pitavastatin, Atorvastatin, and Rosuvastatin in Participants With Renal Insufficiency in the Presence and Absence of Rifampin (MK-0000-386)
Status: COMPLETED
Conditions: Renal Insufficiency
Interventions: DRUG: Midazolam oral solution|DRUG: Dabigatran and pitavastatin oral solution|DRUG: Atorvastatin and rosuvastatin oral solution|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Oxytocin Nasal Inhalation on Empathy Analgesia
Status: COMPLETED
Conditions: Oxytocin|Pain|Empathy|Social Familiarity|Analgesia
Interventions: DRUG: Oxytocin nasal spray|DRUG: Placebo|BEHAVIORAL: Stranger|BEHAVIORAL: Acquaintance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Polatuzumab Vedotin in Combination With Bendamustine and Rituximab Compared With Bendamustine and Rituximab Alone in Chinese Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (R/R DLBCL).
Status: TERMINATED
Conditions: Diffuse, Large B-Cell, Lymphoma
Interventions: DRUG: Polatuzumab Vedotin|DRUG: Bendamustine|DRUG: Rituximab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Vascular Effects of Vildagliptin in Insulin Resistant Individuals
Status: COMPLETED
Conditions: Insulin Resistance|Microvascular Disease
Interventions: DRUG: Vildagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Multi-Centric Clinical Study of Chinese Medicine Intervention on Diabetes Distal Symmetric Polyneuropathy.
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Tangbi (prescription)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of ALC in Breast Cancer in Subjects With Fatigue
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: ALC and Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Training in Virtual Environment With and Without Physiotherapeutic Intervention in Chronic Stroke Patients
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: No Physiotherapeutic Intervention|OTHER: Physiotherapeutic Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate The Pharmacokinetics Of Crizotinib (PF-02341066) In Subjects With Impaired Renal Function
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: crizotinib|DRUG: crizotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multi-center Phase I/IIa Trial of an Autologous Tumor Lysate (TL) + Yeast Cell Wall Particles (YCWP) + Dendritic Cells (DC) Vaccine in Addition to Standard of Care Checkpoint Inhibitor of Choice in Metastatic Melanoma Patients With Measurable Disease.
Status: COMPLETED
Conditions: Metastatic Melanoma
Interventions: DRUG: TLPLDC Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug-Drug Interaction Study Between GDC-0853 and Midazolam, Itraconazole, Rosuvastatin, and Simvastatin
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Midazolam|DRUG: GDC-0853|DRUG: Midazolam and GDC-0853|DRUG: Rosuvastatin|DRUG: Rosuvastatin and GDC-0853|DRUG: Simvastatin|DRUG: Simvastatin and GDC-0853|DRUG: GDC-0853|DRUG: Itraconazole|DRUG: GDC-0853 and itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: HHV8 and Solid Organ Transplantation
Status: RECRUITING
Conditions: HHV8|HHV8 Infection|HHV8-Related Malignant Neoplasm|Kaposi Sarcoma|Lung Transplant; Complications|Liver Transplant; Complications|Kidney Transplant; Complications|Castleman Disease
Interventions: DIAGNOSTIC_TEST: Diagnostic test for HHV8 exposure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Development of a Parent-mediated Mobile App Intervention for Parents of Children With Autism Spectrum Disorder Participating in an Adapted Horseback Riding Program
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: OTHER: Mobile app intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Extracorporeal Shockwave Therapy in Insertional Achilles Tendinopathy
Status: COMPLETED
Conditions: Insertional Achilles Tendinopathy
Interventions: DEVICE: Extracorporeal Shock Wave Therapy|DEVICE: Sham Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Extension Study of HGT-HIT-045 Evaluating Long-Term Safety and Clinical Outcomes of Idursulfase-IT in Conjunction With Elaprase in Pediatric Participants With Hunter Syndrome and Cognitive Impairment
Status: COMPLETED
Conditions: Hunter Syndrome
Interventions: DRUG: Idursulfase-IT|DRUG: Elaprase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase Ib/II Study of Efficacy and Safety of MEK162 and Panitumumab, in Adult mCRC Patients With Mutant or Wild-type RAS Tumors
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: MEK162|DRUG: Panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A 3-Part Study to Evaluate the Safety, Tolerability, PK, and Food Effect of BMB-101 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BMB-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Hemodialysis Arteriovenous Fistulae Stenosis Treated With APERTO
Status: COMPLETED
Conditions: Peripheral Arterial Disease|Fistula
Interventions: DEVICE: Paclitaxel Releasing Peripheral Balloon Dilatation Catheter|DEVICE: Balloon Dilatation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Question Prompt List for Patients With Myelodysplastic Syndromes (QPL-MDS)
Status: UNKNOWN
Conditions: Myelodysplastic Syndromes
Interventions: BEHAVIORAL: Question prompt list (QPL)|BEHAVIORAL: Education brochure of Groupe Français des Myélodysplasies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety & Immunogenicity of Enterovirus Type 71 Vaccine in Healthy Adults and Children 6-71months
Status: COMPLETED
Conditions: Hand Foot & Mouth Disease
Interventions: BIOLOGICAL: Inactivated Enterovirus Type 71 (EV71) Vaccine (Vero Cell)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Plasmapheresis Versus Plasma Infusion From Young APOE3 Homozygotes Into MCI APOE4 Homozygotes to Slow Disease Progression
Status: ENROLLING_BY_INVITATION
Conditions: Mild Cognitive Impairment
Interventions: BIOLOGICAL: Plasmapheresis|BIOLOGICAL: Plasma infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Efficacy and Safety of Agomelatine in the Patients With Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease|Depression|Sleep Disorders|Circadian Rhythm Disorders
Interventions: DRUG: Agomelatine or PIacebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Cognitive Intervention on Cognition, Mobility and Brain Electrocortical Activity
Status: COMPLETED
Conditions: Cognitive Decline|Cognitive Impairment|Aging|Motor Coordination or Function
Interventions: OTHER: Computerized cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ketorolac Use in Pediatric Patients Undergoing Tonsillectomy
Status: UNKNOWN
Conditions: Analgesic Adverse Reaction
Interventions: DRUG: Ketorolac Tromethamine|DRUG: 0.9% Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Asenapine for Bipolar Depression
Status: TERMINATED
Conditions: Bipolar Depression
Interventions: DRUG: Asenapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Insulin Glargine Plus Insulin Glulisine Multiple Daily Injections (MDI) Versus Premix Insulin Treatment in Subjects With Diabetes Mellitus (Type 1 or Type 2)
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: insulin glargine|DRUG: insulin glulisine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dexmedetomidine and Esketamine Combined Infusion Quality of Sleep Undergoing Modified Radical Mastectomy
Status: RECRUITING
Conditions: Dexmedetomidine Plus Esketamine Affect Postoperative Sleep Quality
Interventions: DRUG: Dexmedetomidine administration|DRUG: Dexmedetomidine plus low-dose esketamine administration|DRUG: Dexmedetomidine plus high-dose esketamine administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety, Tolerability and Immune Response of TBE Vaccines Administered to Healthy Children
Status: COMPLETED
Conditions: Encephalitis, Tick-Borne
Interventions: BIOLOGICAL: Tick-Borne Encephalitis vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: Erlotinib in Treating Women Undergoing Surgery For Stage I, Stage II, or Stage III Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: erlotinib hydrochloride|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|PROCEDURE: biopsy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stimulation With Wire Leads to Restore Cough
Status: COMPLETED
Conditions: Spinal Cord Injuries|Spinal Cord Diseases|Paralysis|Central Nervous System Diseases|Cough|Trauma, Nervous System|Wounds and Injuries
Interventions: DEVICE: Expiratory muscle stimulator|PROCEDURE: Implantation of device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Objective Assessment of Macular Function at Retinal and Cortical Levels
Status: UNKNOWN
Conditions: Macula; Degeneration, Congenital or Hereditary|Retina Disorder
Interventions: DIAGNOSTIC_TEST: functional magnetic resonance imaging (fMRI)|DIAGNOSTIC_TEST: Microperimetry (MP)|DIAGNOSTIC_TEST: Optical coherence tomography (OCT)|DIAGNOSTIC_TEST: Blue light fundus autofluorescence imaging (FAF)|DIAGNOSTIC_TEST: Visual testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Escalated Single Platelet Inhibition for One Month Plus NOAC in Patients With Atrial Fibrillation and ACS Undergoing PCI
Status: RECRUITING
Conditions: Acute Coronary Syndrome|Atrial Fibrillation
Interventions: DRUG: Prasugrel or Ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety Following Immune Tolerance Induction Treatment With Turoctocog Alfa in Patients With Haemophilia A Following Inhibitor Development in NN7170-4213 Trial
Status: TERMINATED
Conditions: Haemophilia A
Interventions: DRUG: Turoctocog alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Superiority, Efficacy and Tolerability of Combination Pantovigar With 2% Minoxidil vs 2% Minoxidil in Women With Female Pattern Hair Loss
Status: COMPLETED
Conditions: Female Pattern Hair Loss|Androgenetic Alopecia (AGA)|Ludwig Type 1|Ludwig Type 2
Interventions: DRUG: Pantovigar|DRUG: Minoxidil 2% only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Long-Term Safety of ICA-17043 in Sickle Cell Disease Patients With or Without Hydroxyurea Therapy
Status: TERMINATED
Conditions: Sickle Cell Disease|Sickle Cell Anemia
Interventions: DRUG: ICA-17043
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Experimental Therapeutic Cancer Vaccine Created In-situ in Patients With Stage II-Stage IV Cancer
Status: COMPLETED
Conditions: Solid Tumors Stage II, Stage III and Stage IV|Breast Cancer|Colorectal Cancer|Prostate Cancer|Melanoma|Ovarian Cancer|Sarcoma|Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: AlloStim|PROCEDURE: Cryoablation|BIOLOGICAL: AlloStim|BIOLOGICAL: AlloStim|BIOLOGICAL: AlloStim|BIOLOGICAL: AlloStim|BIOLOGICAL: AlloStim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reducing Anxiety of Children and Their Parents in the Pre-Operative Process With Therapeutic Play
Status: UNKNOWN
Conditions: Preoperative Care|Child|Parents|Anxiety
Interventions: OTHER: Bubble breathing play therapy group|OTHER: Tell-show-do play therapy group|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Pre-visit Digital Messaging Improves Patient Reported Outcome Measure Participation Prior to the Orthopedic Ambulatory Visit
Status: COMPLETED
Conditions: Orthopedic Disorder
Interventions: OTHER: Pre-Visit Messages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Combining Stellate Ganglion Block With Prolonged Exposure for PTSD
Status: RECRUITING
Conditions: Stress Disorders, Post-Traumatic
Interventions: DRUG: Ropivacaine injection|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Multisession Mindful Breathing in Symptom Reduction Among Patients With Advanced Cancers
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: BEHAVIORAL: Mindful breathing|OTHER: Standard care (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Protocol for the Treatment of Patients With Previously Untreated Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Hypoxic, Normobaric and Hypobaric Training on the Immunometabolism of Post-covid-19 Athletes
Status: RECRUITING
Conditions: Normobaric Hypoxia|Hypoventilation|Normoxia
Interventions: OTHER: Repeated sprint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of the Efficacy and Safety of the Drug Ingaron (Interferon-gamma) in the Treatment of Anogenital Warts
Status: COMPLETED
Conditions: Human Papillomavirus Infection|Anogenital Warts
Interventions: DRUG: Interferon gamma human recombinant (IFN-G)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AZD5363 in Patients With Advanced Solid Tumors Harboring AKT Mutations
Status: COMPLETED
Conditions: Breast Cancer|Prostate Cancer|Advanced Solid Tumors
Interventions: DRUG: AZD5363|DRUG: Enzalutamide|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety, Tolerability, Pharmacokinetics and Food Effects of IMM-H014 in Healthy Subjects
Status: RECRUITING
Conditions: Nonalcoholic Steatohepatitis (NASH)
Interventions: DRUG: IMM-H014|DRUG: Placebo|DRUG: IMM-H014 ( FE)|DRUG: Placebo ( FE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bladder Scan of Residual Urine With New Catheter
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: DEVICE: Test Catheter - SpeediCath Compact Male|DEVICE: SpeediCath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Real Life of Aflibercept in France in Patients Refractory to Ranibizumab: Observational Study in Wet AMD
Status: COMPLETED
Conditions: Wet Macular Degeneration
Interventions: DRUG: Aflibercept (EYLEA, BAY-86-5321)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SAM-e for the Treatment of Depression in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease|Depression
Interventions: DRUG: SAM-e|DRUG: oral escitalopram|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: e-Health Coping Skills Training for Women Whose Partner Has a Drinking Problem
Status: ACTIVE_NOT_RECRUITING
Conditions: Alcohol Abuse
Interventions: BEHAVIORAL: eHealth Coping Skills Training|BEHAVIORAL: eHealth Usual Web Care|BEHAVIORAL: Coach Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Dry Needling on Stiffness in Latent Trigger Points
Status: COMPLETED
Conditions: Trigger Points
Interventions: DEVICE: Intervention-Dry Needling|DEVICE: Control-Dry Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metformin And Chloroquine in IDH1/2-mutated Solid Tumors
Status: COMPLETED
Conditions: Glioma|Cholangiocarcinoma|Chondrosarcoma
Interventions: DRUG: Metformin and chloroquine combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone in Refractory or First Relapsed Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Relapsed or Refractory Acute Myeloid Leukemia
Interventions: DRUG: Dexamethasone|DRUG: Amsacrine|DRUG: Cytarabine|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Cryotherapy Combined With Compression Therapy for Preventing Chemotherapy-induced Peripheral Neuropathy
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DEVICE: Frozen glove and sock|DRUG: ddEC-ddT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Synthetic Bone Graft Substitute vs. Autologous Spongiosa in Revision Anterior Cruciate Ligament Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injury
Interventions: PROCEDURE: Actifuse|PROCEDURE: bone graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin E-containing Dressing on Surgical Site Infection in Colorectal Surgery
Status: UNKNOWN
Conditions: Surgical Site Infection
Interventions: DRUG: Vitamin E|DRUG: Standard dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Image-guided Cryoablation of Head, Neck and Spine Tumors
Status: COMPLETED
Conditions: Head and Neck Neoplasms|Malignant Neoplasm of Vertebral Column
Interventions: DEVICE: Cryoablation|DEVICE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trauma Intervention for Affect Regulation, AIDS, and Substances
Status: COMPLETED
Conditions: Human Immunodeficiency Virus|Substance Related Disorder|Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: Neutral Writing|BEHAVIORAL: Expressive Writing|BEHAVIORAL: Contingency Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer
Status: RECRUITING
Conditions: Leptomeningeal Metastasis
Interventions: DRUG: Osimertinib|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Total Intravenous Anaesthesia With Propofol on Postoperative Pain After Bilateral Third Molar Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Grinding Versus Standard Methods for the Treatment of Per-operative Bacteriological Samples Associated With Osteo-articular Sepsis
Status: COMPLETED
Conditions: Bacterial Infection
Interventions: BIOLOGICAL: Biological sampling grinding|BIOLOGICAL: Biological sampling with standard procedures
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Adalimumab in Alleviating Inflammation in Patients With Axial Spondyloarthritis
Status: UNKNOWN
Conditions: Ankylosing Spondyloarthritis
Interventions: DRUG: Adalimumab|OTHER: PET/CT imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cadmium-zinc-telluride (CZT) Imaging of Myocardial Blood Flow (MBF) (SPECT MBF)
Status: UNKNOWN
Conditions: Coronary Heart Disease
Interventions: OTHER: single photon emission computed tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Efficacy, Safety and Tolerability of Bermekimab in Patients With Hidradenitis Suppurativa
Status: COMPLETED
Conditions: Hidradenitis Suppurativa|Acne Inversa|Suppurative Hidradenitis
Interventions: DRUG: bermekimab|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Creating a Buttonhole Tunnel Track by Repeated Needling of the AV Fistula on the Same Day in Patients on Hemodialysis.
Status: ACTIVE_NOT_RECRUITING
Conditions: End-stage Renal Disease (ESRD)
Interventions: PROCEDURE: Repeated cannulation Buttonhole.|PROCEDURE: Single cannulation Buttonhole.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Ashwagandha Extract (Capsule KSM-66 300 mg) on Sexual Health in Healthy Women
Status: RECRUITING
Conditions: Sexual Health
Interventions: DIETARY_SUPPLEMENT: Ashwagandha|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Live Biotherapeutic Product GB104 Phase 1 Study in Colorectal Cancer
Status: RECRUITING
Conditions: Solid Tumor|Colorectal Cancer|Sigmoid Colon Cancer|Rectosigmoid Junction Cancer|Cancer|Rectal Cancer
Interventions: DRUG: GB104(Level 1)|DRUG: GB104(Level 2)|DRUG: GB104(Level 3)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Aerobic Exercises on Sex Hormones and Coagulation Factors in Postmenopausal Elderly Women
Status: UNKNOWN
Conditions: Coagulation Disorder
Interventions: OTHER: aerobic exercises in addition to diet recommendations|OTHER: diet recommendations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Yoga in Reducing Chemotherapy Induced Nausea and Vomiting
Status: COMPLETED
Conditions: Breast Cancer|Malignant Female Reproductive System Neoplasm|Lymphomas|Chemotherapy-induced Nausea and Vomiting
Interventions: BEHAVIORAL: yoga|BEHAVIORAL: Jacobsons PMRT group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TAC/MTX vs. TAC/MMF/PTCY for Prevention of Graft-versus-Host Disease and Microbiome and Immune Reconstitution Study (BMT CTN 1703/1801)
Status: COMPLETED
Conditions: Acute Leukemia|Chronic Myelogenous Leukemia (CML)|Myelodysplasia|Lymphoma
Interventions: PROCEDURE: Mobilized Peripheral Blood Stem Cell graft with Tacrolimus/Methotrexate|DRUG: Tacrolimus|DRUG: Methotrexate|PROCEDURE: Mobilized Peripheral Blood Stem Cell graft with Tacrolimus/Mycophenolate Mofetil/Post-Transplant Cyclophosphamide|DRUG: Tacrolimus|DRUG: Mycophenolate Mofetil|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Rectal Sheath Analgesia After Midline Laparotomy
Status: COMPLETED
Conditions: Surgery|Pain Postoperative
Interventions: DRUG: Levobupivacaine continuous infusion|DRUG: levobupivacaine bolus dosing|DRUG: single bolus of levobupivacaine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expiratory and Plasma Propofol Concentration in Gastrological Surgery Patients
Status: UNKNOWN
Conditions: Bariatric Surgery Candidate|Cholecystectomy
Interventions: DEVICE: Edmon (reg), BBraun
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nursing Home Team-Care Deprescribing Study
Status: COMPLETED
Conditions: Fall in Nursing Home|Medication Therapy Management
Interventions: OTHER: Team-care deprescribing with deprescribing guide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Stretching Exercises on Plantar Fascia
Status: NOT_YET_RECRUITING
Conditions: Stretch|Plantar Fascia; Contracture|Fasciitis, Plantar
Interventions: DEVICE: Stretching with/without device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Implementing and Evaluating the Integration of Physical Activity Into a Major Health System and Connecting Patients to Physical Activity Programs.
Status: RECRUITING
Conditions: Chronic Disease|Exercise|Physical Activity
Interventions: OTHER: Invitation to adopt
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: 5-azacytidine Treatment Versus 5-azacytidine Followed by Allogeneic Stem Cell Transplantation in Elderly Patients With Myelodysplastic Syndrome (MDS)
Status: COMPLETED
Conditions: Myelodysplastic Syndrome|Chronic Myelomonocytic Leukemia
Interventions: PROCEDURE: allogeneic stem cell transplantation|PROCEDURE: 5-azacytidine until progress
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microbiota Restoration Therapy in HIV With Repeated Low-Dose Interventions
Status: COMPLETED
Conditions: HIV Infection
Interventions: BIOLOGICAL: FMT|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-Invasive TMS Neuromodulation for Enduring Balance & Locomotion Restoration in Parkinson's Disease
Status: WITHDRAWN
Conditions: Parkinson's Disease
Interventions: DEVICE: Transcranial Magnetic Stimulation (TMS)|DEVICE: MAGSTIM Rapid2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Cabozantinib S-malate and Nivolumab in Treating Patients With Advanced, Recurrent, or Metastatic Endometrial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Endometrial Carcinoma|Metastatic Endometrial Carcinoma|Recurrent Endometrial Carcinoma|Stage III Uterine Corpus Cancer AJCC v8|Stage IV Uterine Corpus Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Cabozantinib S-malate|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Platelet Rich Plasma and Corticosteroid for Military & Civilian Patients With Glenohumeral Osteoarthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis of the Shoulder|Corticosteroid|PRP|Pain
Interventions: BIOLOGICAL: Platelet Rich Plasma Injection|BIOLOGICAL: Corticosteroid Injection|BIOLOGICAL: Delayed Platelet Rich Plasma Injection After Corticosteroid Injection Failure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treating Post-Lyme Disease Syndrome With Acetogenins
Status: COMPLETED
Conditions: Post-Lyme Disease Syndrome (PLDS)
Interventions: DIETARY_SUPPLEMENT: ReaLife+ (RLP)|OTHER: Inert Brown powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of 30%TSC and Heparin Lock Solution in Hemodialysis Catheters
Status: COMPLETED
Conditions: Catheter Related Infection
Interventions: DRUG: 30% TSC|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neural Exercises vs Surgery in Patients With Carpal Tunnel Syndrome
Status: UNKNOWN
Conditions: Neuropathic Pain
Interventions: PROCEDURE: Neural Mobilization|PROCEDURE: Surgery|PROCEDURE: Surgery and neural mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: EEAP Using Moses 2.0 Technology vs the Thulium Fiber Laser in Medium-Large Prostates
Status: NOT_YET_RECRUITING
Conditions: Prostatic Hyperplasia|Surgery|Endoscopic Anatomical Enucleation of the Prostate (EEAP)
Interventions: PROCEDURE: MoLEP|PROCEDURE: ThuFLEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluoride Bioavailability After Ingestion of Water or Foods Prepared With Fluoridated Water
Status: COMPLETED
Conditions: Dental Caries|Dental Fluorosis
Interventions: OTHER: Meal prepared with non fluoridated water|OTHER: Meal prepared with fluoridated water|OTHER: Non fluoridated water|OTHER: Fluoridated water|OTHER: Meal prepared to provide a fluoride dose of 60 ug F/kg|OTHER: Meal prepared to provide a fluoride dose of 120 ug F/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A STUDY TO ESTIMATE THE EFFECT OF PF-06651600 ON THE PHARMACOKINETICS (PK) OF ORAL CONTRACEPTIVE (OC)
Status: COMPLETED
Conditions: Healthy Females
Interventions: DRUG: PF-06651600|DRUG: Ethinyl estradiol (EE) and levonogestrel (LN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Optimizing Graft Selection for ACL Reconstruction
Status: RECRUITING
Conditions: ACL - Anterior Cruciate Ligament Rupture
Interventions: PROCEDURE: QT graft|PROCEDURE: ST/Gr graft|PROCEDURE: BPTB graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Supination/Flexion Maneuver to Hyperpronation Maneuver
Status: TERMINATED
Conditions: Emergencies|Orthopedics|Radial Head Subluxation
Interventions: PROCEDURE: Supination-flexion maneuver|PROCEDURE: Hyperpronation maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rotation or Change of Biotherapy After First Anti-TNF Treatment Failure for Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: infliximab, etanercept, adalimumab|DRUG: abatacept, rituximab or tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Window of Opportunity Trial of Afatinib In Early Stage Non-Small Cell Lung Cancer (NSCLC)
Status: WITHDRAWN
Conditions: Lung Cancer
Interventions: DRUG: BIBW 2992 (Afatinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proteomic Prediction and Renin Angiotensin Aldosterone System Inhibition Prevention Of Early Diabetic nephRopathy In TYpe 2 Diabetic Patients With Normoalbuminuria
Status: COMPLETED
Conditions: Diabetic Nephropathy|Diabetic Retinopathy
Interventions: DRUG: Spironolactone|DRUG: Placebo|DRUG: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: BEST (Burn Center Evaluation of Standard Therapies) Ventilator Mode Study-
Status: TERMINATED
Conditions: Burns
Interventions: DEVICE: Ventilation - High Frequency Percussive Ventilation|DEVICE: Ventilation - ARDSnet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Induction of Hypothyroxinemia Adjunct to Conventional Therapies in GBM Patients
Status: TERMINATED
Conditions: Glioblastoma Multiforme (GBM)
Interventions: DRUG: Combined T3 and Methimazole treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pain Care at Home to Amplify Function (Pain CHAMP)
Status: RECRUITING
Conditions: Opioid Use Disorder|Opioid Misuse|Chronic Pain
Interventions: BEHAVIORAL: TCM|BEHAVIORAL: TCM plus COPES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Prospective Clinical Study of Precision PRaG Therapy in Elderly Patients With Advanced Solid Malignant Tumors (PRaG9.0)
Status: NOT_YET_RECRUITING
Conditions: Carcinoma|Solid Tumor
Interventions: DRUG: ADC Combined With Radiotherapy, PD-L1 Sequential GM-CSF and Thymopentin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of the GenePOC Strep A, C/G Assay for Detecting Group A, C and G β-hemolytic Streptococcus From Throat Swabs.
Status: COMPLETED
Conditions: Pharyngitis, Infective
Interventions: DEVICE: Comparison between GenePOC CR and Reference Method
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: New Double Epigenetic Regimen in the Treatment of Relapsed or Refractory Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Refractory Acute Leukemia|Relapsed Adult AML
Interventions: DRUG: CAHAG regimen|DRUG: Placebo regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Making Football Safer for Women: Implementing an Injury Prevention Program
Status: RECRUITING
Conditions: Anterior Cruciate Ligament Injuries|Concussion, Brain|Musculoskeletal Injury
Interventions: OTHER: Coaching|OTHER: Peer support|OTHER: Educational materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Near Visual Acuity With ODYSIGHT, a Smartphone Based Medical App in Comparison to a Standardized Method
Status: COMPLETED
Conditions: Near Vision
Interventions: OTHER: Standards vision tests|DEVICE: OdySight medical application assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Determine User Acceptability and Laboratory Data Regarding Use of a Novel Indwelling Urinary Catheter: the Optitip Study
Status: WITHDRAWN
Conditions: Urologic Diseases
Interventions: DEVICE: Optitip Catheter (LinC Medical)|DEVICE: Foley catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Different Surgical Modalities in the Treatment of Periodontitis
Status: RECRUITING
Conditions: Chronic Periodontitis
Interventions: PROCEDURE: Non-surgical Subgingival Debridement (SD)|PROCEDURE: Simplified Papilla Preservation Flap|PROCEDURE: Resective Periodontal Flap with Osseous Recontouring (RPFO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physiotherapy Treatment for Chronic Achilles Tendinopathy
Status: COMPLETED
Conditions: Achilles Tendinopathy
Interventions: OTHER: Low-level Laser Therapy|OTHER: Sham Low-level Laser Therapy|OTHER: Exercise therapy|OTHER: Cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Nitric Oxide Nasal Spray (NONS) for Treatment of Recurrent Acute Rhinosinusitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Acute Rhinosinusitis
Interventions: DRUG: Nitric Oxide Releasing Solution|DEVICE: Nasal spray with isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Real Time Instrumentation (RTI) in Total Shoulder Arthroplasty
Status: COMPLETED
Conditions: Anatomic Total Shoulder Arthroplasty
Interventions: DEVICE: Anatomic TSA using RTI|PROCEDURE: Anatomic Total Shoulder Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Simvastatin on Apolipoprotein B-100 (apoB-100) Secretion
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: simvastatin|DRUG: simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety Of AGE ZERO™ EXOSOMES To Treat Men and Women With Androgenetic Alopecia
Status: NOT_YET_RECRUITING
Conditions: Androgenetic Alopecia
Interventions: COMBINATION_PRODUCT: 5 billion exosomes and saline solution microneedling|COMBINATION_PRODUCT: 50 billion exosomes and saline solution microneedling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigate the Efficacy and Safety of Farudodstat Compared With Its Placebo in Adult Alopecia Areata Participants
Status: RECRUITING
Conditions: Alopecia Areata
Interventions: DRUG: Farudodstat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Awareness of Emotional Feelings and Management of Risky Situations
Status: UNKNOWN
Conditions: Risk-Taking|Emotional Regulation
Interventions: BEHAVIORAL: Neurofeedback + BART/EEG|BEHAVIORAL: BART/EEG only
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Motor Imagery and Isometric Exercises on Pelvic Floor Sensorimotor Condition
Status: COMPLETED
Conditions: Isometric Exercise|Motor Imagery|Women's Health
Interventions: BEHAVIORAL: Motor Imagery plus therapeutic exercise|BEHAVIORAL: Therapeutic exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT