pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: EMR Outcomes: Anxiety and Depression in Epilepsy
Status: COMPLETED
Conditions: Quality of Life|Anxiety|Depression|Epilepsy
Interventions: OTHER: EMR-based-interventional method|OTHER: Telephone-based-standard method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Buprenorphine Maintenance vs. Detoxification in Prescription Opioid Dependence
Status: COMPLETED
Conditions: Opiate Dependence
Interventions: BEHAVIORAL: Behavioral: Buprenorphine/naloxone maintenance (Mtn)|BEHAVIORAL: Behavioral: Buprenorphine/naloxone detoxification (Dtx)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Disposable Perfusion Phantom for Accurate DCE (Dynamic Contrast Enhanced)-MRI Measurement of Pancreatic Cancer Therapy Response
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DEVICE: Point-of-care Portable Perfusion Phantom, P4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Single-arm Trial of BIBW 2992 (Afatinib) in Demographically and Genotypically Selected NSCLC Patients
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: BIBW2992|DRUG: BIBW2992 + paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Acupuncture and Fluoxetine on Quality of Life in Menopausal Women
Status: UNKNOWN
Conditions: Hot Flash|Quality of Life
Interventions: PROCEDURE: acupuncture|DRUG: fluoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Mitoxantrone in Patients With Refractory Neuromyelitis Optica and Spectrum Disorders
Status: UNKNOWN
Conditions: Neuromyelitis Optica|Neuromyelitis Optica Spectrum Disorders
Interventions: DRUG: Mitoxantrone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Investigator-Initiated Study of Ribavirin in Indolent Follicular Lymphoma and Mantle Cell Lymphoma
Status: TERMINATED
Conditions: Follicular Lymphoma|Mantle Cell Lymphoma
Interventions: DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Heart Rate Variability Biofeedback in Patients With Acute Ischemic Stroke
Status: COMPLETED
Conditions: Acute Ischaemic Stroke|Autonomic Dysfunction
Interventions: OTHER: Biofeedback|OTHER: Sham-Biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effect of Adjuvant Hyperbaric Oxygen Therapy on Bells Palsy Outcome
Status: WITHDRAWN
Conditions: Bell Palsy
Interventions: DRUG: Oral Corticosteroids|DRUG: Oral antivirals|DEVICE: Hyperbaric Oxygen Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: " The Eyes Have it " : Ocular Saccade Abnormalities in Prodromal Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: OTHER: Neuropsychological assessment|OTHER: ophthalmologic checkup|OTHER: Automated non-invasive oculometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cyclophosphamide and rATG With Hematopoietic Stem Cell Support in Systemic Scleroderma
Status: COMPLETED
Conditions: SYSTEMIC SCLERODERMA
Interventions: DRUG: standard of care|PROCEDURE: stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PENG: an Estimation of ED50 in Neck of Femur Fracture
Status: UNKNOWN
Conditions: Hip Fractures|Pain, Acute
Interventions: DRUG: Bupivacaine Hydrochloride 20ml injectate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Nivolumab in Treating Oral Proliferative Verrucous Leukoplakia
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukoplakia, Oral
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety & Efficacy of EPO-018B for the Treatment of Anemia in Participants With ERSD Receiving Maintenance Hemodialysis
Status: UNKNOWN
Conditions: Chronic Renal Failure|Anemia
Interventions: DRUG: EPO-018B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Culturally Adapted CBT-based Guided Self Help in Depressed Patients With Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction|Depression
Interventions: OTHER: CaCBT based guided self help using Khushi aur Khatoon Manual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BufferGel and PRO 2000/5: Vaginal Gels to Prevent HIV Infection in Women
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: BufferGel|DRUG: PRO 2000/5 Gel|DRUG: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Telerehabilitation on Hand-Affected Scleroderma
Status: COMPLETED
Conditions: Scleroderma|Scleroderma, Systemic|Scleroderma Associated Digital Ulcer|Hand Rheumatism|Physiotherapy|Rehabilitation
Interventions: OTHER: Hand Therapy via Telerehabilitation|OTHER: Hand Therapy via home-exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Propofol Target-Controlled Infusion Anesthesia and Bolus Injection in Electroconvulsive Therapy
Status: COMPLETED
Conditions: Depression|Schizophrenia|Bipolar Disorder|Cognitive Dysfunction
Interventions: DEVICE: Target controlled infusion, Schnider model|BEHAVIORAL: Bolus injection of Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: SARS-CoV-2 Donor-Recipient Immunity Transfer
Status: COMPLETED
Conditions: Accelerated Phase CML, BCR-ABL1 Positive|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Chronic Lymphocytic Leukemia|Chronic Phase CML, BCR-ABL1 Positive|COVID-19 Infection|Hematopoietic and Lymphoid Cell Neoplasm|Hodgkin Lymphoma|Lymphoblastic Lymphoma|Myelodysplastic Syndrome|Myelofibrosis|Myeloproliferative Neoplasm|Non-Hodgkin Lymphoma
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Diagnostic Laboratory Biomarker Analysis|OTHER: Electronic Health Record Review|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TCR Reserved and Power3 Gene Knock-out Allogeneic CD19-targeting CAR-T Cell Therapy in r/r B Cell Lymphoma
Status: RECRUITING
Conditions: Non-hodgkin Lymphoma
Interventions: BIOLOGICAL: TCR reserved and Power3 gene knock-out allogeneic CD19-targeting CAR-T cell (ATHENA-2 CAR-T)|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study To Evaluate The Effect Of A Multiple Oral Dose Of PF-00232798 On QT Intervals In Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-00232798|DRUG: PF-00232798|DRUG: Placebo|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Video-led Smoking Cessation Intervention in Helping Male Smokers Whose Partners Got Pregnant to Quit Smoking
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: COMBINATION_PRODUCT: Video+brief smoking cessation+pamphlet|COMBINATION_PRODUCT: Text-message+brief smoking cessation+pamphlet|OTHER: brief smoking cessation+pamphlet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Masitinib Plus Docetaxel in Metastatic Castration-resistant Prostate Cancer
Status: COMPLETED
Conditions: Metastatic Castrate Resistant Prostate Cancer
Interventions: DRUG: Masitinib|DRUG: Docetaxel|DRUG: Prednisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exposure Therapy for Active Duty Soldiers With Post Traumatic Stress Disorder
Status: COMPLETED
Conditions: Stress Disorders, Post Traumatic
Interventions: BEHAVIORAL: Prolonged Exposure Therapy (PE)|BEHAVIORAL: Virtual Reality Exposure Therapy (VRET)|BEHAVIORAL: Waitlist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of ABT-510 in Subjects With Advanced Renal Cell Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: ABT-510/Thrombospondin-1 mimetic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Impact of Providing High Protein Bar to Dialysis Patients With Low Serum Albumin
Status: COMPLETED
Conditions: End Stage Renal Disease|Hypoalbuminemia|Malnutrition
Interventions: DIETARY_SUPPLEMENT: Protein Food Bar Intelligent Indulgence|DIETARY_SUPPLEMENT: Protein Food Bar Intelligent Indulgence|DIETARY_SUPPLEMENT: Protein Food Bar Intelligent Indulgence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Safety and Tolerability of Dexlansoprazole Injection in Healthy Chinese Adults (Part 1)
Status: COMPLETED
Conditions: Safety Issues
Interventions: DRUG: dexlansoprazole injection|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: R-CHOP + GM-CSF for Previously Untreated LCL in Elderly
Status: COMPLETED
Conditions: Lymphoma, Large B-Cell, Diffuse
Interventions: DRUG: R-CHOP+GM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monitoring Spondyloarthritis With SpA-Net
Status: COMPLETED
Conditions: Spondyloarthritis|Ankylosing Spondylitis|Psoriatic Arthritis|Spondyloarthropathy
Interventions: OTHER: Patient initiated care + telemonitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Radiation Therapy and Docetaxel Followed by Standard Therapy in Treating Women With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: docetaxel|DRUG: epirubicin hydrochloride|DRUG: fluorouracil|PROCEDURE: neoadjuvant therapy|PROCEDURE: therapeutic conventional surgery|RADIATION: hypofractionated radiation therapy|RADIATION: image-guided radiation therapy|RADIATION: radiation therapy|RADIATION: stereotactic radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacology and Non-pharmacology Approaches in Reducing Children's Pain and Fear During Painful Procedures
Status: ENROLLING_BY_INVITATION
Conditions: Pain
Interventions: BEHAVIORAL: TICK-B|DRUG: TKTX-Cream|OTHER: TICK-B and TKTX-C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vaccine Response to COVID-19 Vaccines in Patients Using Immunosuppressive Medication
Status: ACTIVE_NOT_RECRUITING
Conditions: Rheumatoid Arthritis|Psoriatic Arthritis|Spondyloarthritis|Crohn Disease|Ulcerative Colitis|Autoimmune Hepatitis|Liver Transplant; Complications
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Laser-Assisted Versus Conventional Intracytoplasmic Sperm Injection
Status: COMPLETED
Conditions: Infertility|Infertility, Male
Interventions: PROCEDURE: Laser-assisted intracytoplasmic sperm injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Chewing Gum on Small Bowel Transit Time
Status: COMPLETED
Conditions: Bowel Transit Times
Interventions: OTHER: Trident sugarless chewing gum.|OTHER: One control group (these do not chew gum).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Albumin for Acute Encephalopathy in Patients With Cirrhosis
Status: COMPLETED
Conditions: Hepatic Encephalopathy
Interventions: DRUG: Albumin|DRUG: Sodium chloride 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of an HIV Vaccine in Healthy, HIV Uninfected Adults
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: MVA Mosaic|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Stereotactic Ablative Radiotherapy for Oligo-Progressive Disease REfractory to Systemic Therapy in Metastatic Cancer
Status: RECRUITING
Conditions: Head and Neck Cancer|Metastatic Cancer|Oligoprogressive
Interventions: OTHER: Standard arm|RADIATION: Experimental arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Measure the Amount of Evacetrapib That Enters the Blood Stream in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Evacetrapib Tablet|DRUG: Evacetrapib Intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Open-label, Randomized, Parallel, Non Comparative, Phase II Trial of Nivolumab Plus Ipilimumab Versus Platinum-based Chemotherapy Plus Nivolumab in Chemonaive Metastatic or Recurrent Squamous-Cell Lung Cancer (SqLC)
Status: UNKNOWN
Conditions: Squamous-Cell Lung Cancer
Interventions: DRUG: Nivolumab plus Ipilimumab|DRUG: Platinum-based chemotherapy plus Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calcitriol, Ketoconazole, and Dexamethasone in Treating Patients With Metastatic or Unresectable Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DIETARY_SUPPLEMENT: calcitriol|DRUG: dexamethasone|DRUG: ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Peer-Delivered HIV Self-Testing, STI Self-Sampling and PrEP for Transgender Women in Uganda
Status: UNKNOWN
Conditions: HIV|Sexually Transmitted Infections|PrEP|Transgender Women
Interventions: OTHER: Peer-delivered HIV self-testing, STI self-sampling and PrEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sleep Extension to Improve Sleep Efficiency and QoL in HF With Preserved Ejection Fraction: the SLEEP-HF Pilot Study
Status: NOT_YET_RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: BEHAVIORAL: Customized Sleep Coaching|BEHAVIORAL: Sleep Hygiene Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Neuromonitoring Recording With a Novel SCS Paddle
Status: COMPLETED
Conditions: Chronic Pain|Neuropathic Pain|Failed Back Surgery Syndrome|Complex Regional Pain Syndromes
Interventions: DEVICE: HD Study Electrode
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Thorough QT (TQT) Study to Evaluate the Effect of LC350189 on Cardiac Repolarization in Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Hyperuricemia|Gout|Qt Interval, Variation in
Interventions: DRUG: LC350189 200mg|DRUG: Placebo|DRUG: Moxifloxacin 400mg|DRUG: LC350189 600mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy and Safety of Loxacon Dietary Supplement Capsules at Patients With Knee Arthrosis
Status: COMPLETED
Conditions: Osteo Arthritis Knee
Interventions: DRUG: • harpagozid • boswellin = LOXACON
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effectiveness of Calcium Channel Blockade for OP and Carbamate Pesticide Poisoning
Status: ACTIVE_NOT_RECRUITING
Conditions: Anticholinesterase Insecticide Poisoning|Pesticide Poisoning
Interventions: DRUG: Magnesium Sulfate|DRUG: Nimodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting HIV Risk Reduction Among People Who Inject Drugs: A Stepped Care Approach Using Contingency Management With PrEP Adherence and Support Services
Status: RECRUITING
Conditions: Opioid-use Disorder|HIV Prevention Program
Interventions: BEHAVIORAL: Contingency Management with stepped care to PrEP adherence and support services (CoMPASS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Desensitizers in Reducing Post Tooth Preparation Sensitivity for a Fixed Dental Prosthesis
Status: COMPLETED
Conditions: Dentin Hypersensitivity
Interventions: BIOLOGICAL: Desensitizers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Neoadjuvant Low-dose Radiotherapy Combined With Chemoimmunotherapy in Locally Advanced HNSCC
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma|Neoadjuvant Treatment
Interventions: DRUG: Tislelizumab|RADIATION: Low-dose radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antioxidant Capacity and Vitamin A Profile in Young Adults Who Consume a Snack Bar Made From Tropical Fruits Treated With UV-C
Status: COMPLETED
Conditions: Nutritional and Metabolic Disease
Interventions: OTHER: No Intervention|DIETARY_SUPPLEMENT: Pineapple snack bar|DIETARY_SUPPLEMENT: Mango snack bar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Azithromycin-based Therapy for Bronchiolitis Obliterans
Status: TERMINATED
Conditions: Graft vs Host Disease|Bronchiolitis Obliterans
Interventions: DRUG: azithromycin + N-acetylcystein + inhaled corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Study of Arginine Supplementation and the Postoperative Immune REsponse
Status: RECRUITING
Conditions: Preterm|Surgery|Nutritional Deficiency|Immune System and Related Disorders
Interventions: DIETARY_SUPPLEMENT: Arginine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: TACE Combined With Sintilimab Plus Bevacizumab Biosimilar in Hepatocellular Carcinoma (BCLC-C Stage ): a Prospective Single-arm Phase II Clinical Study
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Sintilimab; Bevacizumab Biosimilar
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelination And Neurodegeneration
Status: RECRUITING
Conditions: Multiple Sclerosis|Primary Progressive Multiple Sclerosis|Secondary-progressive Multiple Sclerosis
Interventions: DRUG: Metformin Hydrochloride 850 mg Oral Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment for Sexual Dysfunction in Women With Spinal Cord Injury
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Transcutaneous tibial nerve stimulation TENS® EMS NMS60 device|DEVICE: Genital vibration with Ferticare 2.0® vibrator|DEVICE: TENS® EMS NMS60 device_sham intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tipifarnib in Treating Young Patients With Recurrent or Progressive High-Grade Glioma, Medulloblastoma, Primitive Neuroectodermal Tumor, or Brain Stem Glioma
Status: COMPLETED
Conditions: Childhood High-grade Cerebral Astrocytoma|Childhood Oligodendroglioma|Recurrent Childhood Brain Stem Glioma|Recurrent Childhood Cerebellar Astrocytoma|Recurrent Childhood Cerebral Astrocytoma|Recurrent Childhood Medulloblastoma|Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor|Recurrent Childhood Visual Pathway and Hypothalamic Glioma
Interventions: DRUG: tipifarnib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Pioglitazone and Carboplatin in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumor|Metastatic Solid Tumor
Interventions: DRUG: carboplatin|DRUG: pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II / III Study of COVID-19 DNA Vaccine (AG0302-COVID19)
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Group A (AG0302-COVID19)|BIOLOGICAL: Group A (Placebo)|BIOLOGICAL: Group B (AG0302-COVID19)|BIOLOGICAL: Group B (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ultrafast Truxima Infusion in Non-Hodgkin's Lymphoma: Txagorapid Study
Status: UNKNOWN
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: RiTUXimab Injection [Truxima]|DRUG: RiTUXimab Injection [Truxima]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FDG-PET-CT and Biomarkers in Esophageal Cancer
Status: COMPLETED
Conditions: Gastrointestinal Disease|Esophageal Cancer
Interventions: PROCEDURE: PET/CT (FDG PET/CT)|OTHER: Biomarker Testings
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure
Status: COMPLETED
Conditions: Chronic Heart Failure
Interventions: DRUG: carvedilol|DRUG: bisoprolol|DRUG: Nebivolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lamivudine Plus Interferon Versus Lamivudine For The Treatment Of HBeAg Positive Chronic Hepatitis B Virus (HBV)
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: Lamivudine plus Polyethylene glyco-interferon alfa-2b|DRUG: Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Filanesib (ARRY-520) and Carfilzomib in Patients With Advanced Multiple Myeloma
Status: COMPLETED
Conditions: Advanced Multiple Myeloma
Interventions: DRUG: Carfilzomib, proteasome inhibitor; intravenous|DRUG: Filanesib, KSP(Eg5) inhibitor; intravenous|DRUG: Dexamethasone, steroid; oral or intravenous|DRUG: Filgrastim, granulocyte-colony stimulating factor (G-CSF); subcutaneous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Bone Marrow Derived Stem Cells in Decompensate Cirrhotic Patients
Status: COMPLETED
Conditions: Liver Cirrhosis
Interventions: BIOLOGICAL: MNC|BIOLOGICAL: CD133|BIOLOGICAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Fulvestrant With or Without Dasatinib in Men and Postmenopausal Women Who Have Hormone Receptor-positive Advanced Breast Cancer Previously Treated With an Aromatase Inhibitor
Status: COMPLETED
Conditions: Advanced Breast Cancer
Interventions: DRUG: Dasatinib|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selective Avoidance of Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy In HER-2 Positive/Triple Negative Breast Cancer Patients With Excellent Radiologic Response to the Breast and Axilla, Prospective, Multi-center, Single-arm (ASLAN) Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: PROCEDURE: avoid axillary sentinel lymph node biopsy after neoadjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Unexpected Death in Simulation: Skill Retention, Stress and Emotions
Status: COMPLETED
Conditions: Crisis Resource Management (CRM) Skills|Stress|Advanced Cardiovascular Life Support (ACLS) Skills
Interventions: OTHER: Unexpected death
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: FOLFOXIRI Compared to FOLFOX in First Line Treatment of Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: FOLFOXIRI|DRUG: FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Chronic Kidney Diseases
Interventions: BEHAVIORAL: Home-based walking exercise|OTHER: Attention control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Oxycodone Versus Sufentanil on Pain and Inflammatory Response After TACE
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Transcatheter Arterial Chemoembolization|Pain|Inflammation
Interventions: DRUG: Oxycodone|DRUG: Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Study of TPN171H Tablets in Patients With Mild to Moderate Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: TPN171H 2.5mg|DRUG: TPN171H 5mg|DRUG: TPN171H 10mg|DRUG: Placebo 5mg|DRUG: Placebo 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine and Long-term Outcomes in Elderly Patients After Cardiac Surgery
Status: COMPLETED
Conditions: Cardiac Surgery|Dexmedetomidine|Long-term Outcome|Mortality|Quality of Life
Interventions: DRUG: dexmedetomidine hydrochloride for injection|DRUG: 0.9% sodium chloride for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase III Double-blind, Placebo-controlled Study of AZD7442 for Pre-exposure Prophylaxis of COVID-19 in Adult.
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: AZD7442|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy in Treating Patients With Early Stage Breast Cancer That Has Been Removed By Surgery
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: BIOLOGICAL: pegfilgrastim|DRUG: capecitabine|DRUG: cyclophosphamide|DRUG: epirubicin hydrochloride|DRUG: fluorouracil|DRUG: methotrexate|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: |Primary Purpose: TREATMENT
Clinical trial: GSK1572932A Antigen-Specific Cancer Immunotherapeutic as Adjuvant Therapy in Patients With Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer, Non-Small Cell
Interventions: BIOLOGICAL: GSK1572932A Antigen-Specific Cancer Immunotherapeutic|BIOLOGICAL: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Electrophysiological Phenotyping Of Patients at Risk of Ventricular Arrhythmia and Sudden Cardiac Death
Status: UNKNOWN
Conditions: Arrhythmia|Sudden Cardiac Death|Cardiomyopathy, Dilated|Obesity|Inflammation
Interventions: OTHER: Electrocardiographic imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID)
Status: COMPLETED
Conditions: Agammaglobulinemia|IgG Deficiency|Common Variable Immunodeficiency
Interventions: DRUG: Immunoglobulins Intravenous (Human)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of Oral Antibiotics for Treatment of Shoulder PJI
Status: UNKNOWN
Conditions: Periprosthetic Infection|Oral Antibiotics|Revision Total Shoulder Arthroplasty
Interventions: DRUG: Doxycycline 100 MG Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The COMA Family Program: A Skills-Based Resiliency Program for Caregivers of Patients With Severe Acute Brain Injuries
Status: NOT_YET_RECRUITING
Conditions: Coma|Emotional Distress
Interventions: BEHAVIORAL: COMA-F
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: DIagnostic Biomarkers and Symptoms in Patients With Alzheimer's Disease and Lewy bodY Dementia
Status: ACTIVE_NOT_RECRUITING
Conditions: Dementia With Lewy Bodies|Alzheimer Disease|Mild Cognitive Impairment
Interventions: DIAGNOSTIC_TEST: Real-time quaking-induced conversion (RT-QuIC)|DIAGNOSTIC_TEST: Cognitive test|DIAGNOSTIC_TEST: Motor examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pay-it-forward RCT for Gonorrhea and Chlamydia Testing
Status: COMPLETED
Conditions: Gonorrhea Male|Chlamydia;M
Interventions: OTHER: Pay-it-forward|OTHER: Pay-what-you-want
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Muscular Respiratory Involvement and Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis|Diaphragm Defect|Respiratory Insufficiency|Pulmonary Function Test|Diaphragmatic Electromyography|Muscular Weakness
Interventions: DIAGNOSTIC_TEST: Pulmonary function test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Intracardiac CrYoablation for AtrioVentricular Nodal Reentrant Tachycardia
Status: COMPLETED
Conditions: AtrioVentricular Nodal Reentrant Tachycardia|Supraventricular Tachycardia|Heart Disease
Interventions: DEVICE: Freezor Xtra Cryoablation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigation of Safety and Tolerability of NNC0114-0006 in Subjects With Systemic Lupus Erythematosus (SLE)
Status: TERMINATED
Conditions: Inflammation|Systemic Lupus Erythematosus
Interventions: DRUG: NNC0114-0006|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neuroplastic Adaptations in Youth at High Risk for Developing Psychopathology
Status: NOT_YET_RECRUITING
Conditions: Emotion Regulation
Interventions: BEHAVIORAL: Emotion Regulation Skills + Treatment as Usual|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Reslizumab in Patients 12 Years of Age and Older With Severe Eosinophilic Asthma
Status: TERMINATED
Conditions: Eosinophils, Asthma
Interventions: DRUG: reslizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endostar Combined With IP Second-line Treatment of Advanced Esophageal Squamous Cell Carcinomas
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Irinotecan|DRUG: DDP|DRUG: Endostar
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serial Ultrasound in Metastatic Renal Cell Carcinoma (mRCC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Kidney Cancer|Renal Cell Carcinoma|Metastatic Renal Cell Carcinoma
Interventions: DIAGNOSTIC_TEST: Doppler Ultrasound|DEVICE: SIEMENS S3000 and Verasonics Vantage 256|DRUG: Vascular Endothelial Growth Factor Receptor 2 tyrosine kinase inhibitor plus immune checkpoint inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Impact of Bedside Wipes in Multi-patient Rooms: a Prospective, Crossover Trial Evaluating Infections and Survival
Status: COMPLETED
Conditions: Hospital Acquired Infection
Interventions: OTHER: Single-use wipes installed at the bedside
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: |Primary Purpose: PREVENTION
Clinical trial: Oral Lactoferrin Versus Iron Supplementation During Pregnancy
Status: COMPLETED
Conditions: Iron-deficiency
Interventions: DRUG: Lactoferrin|DRUG: Iron Supplement|DRUG: Chelates, Iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Protocol to Collect Human Serum Samples From Healthy Adults for Use as Quality Controls Samples in GlaxoSmithKline (GSK) Biologicals' Assays
Status: COMPLETED
Conditions: Meningococcal
Interventions: BIOLOGICAL: Menveo®|BIOLOGICAL: Boostrix®|BIOLOGICAL: Pneumovax 23®|BIOLOGICAL: Prevnar 13®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Ensifentrine on Sputum Markers of Inflammation in COPD
Status: RECRUITING
Conditions: COPD
Interventions: DRUG: Ensifentrine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VRC 601: A Phase I, Open-Label, Dose-Escalation Study of the Safety and Pharmacokinetics of a Human Monoclonal Antibody, VRC HIVMAB060-00-AB (VRC01), With Broad HIV-1 Neutralizing Activity, Administered Intravenously or Subcutaneously to HIV-Infected...
Status: COMPLETED
Conditions: HIV-1 Infection|Neutralizing Antibody|Monoclonal Antibody|Viral Load|HIV Antibodies
Interventions: BIOLOGICAL: VRC-HIVMAB060-00-AB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Soluble Corn Fiber for Promoting Executive Function Study
Status: UNKNOWN
Conditions: Health
Interventions: DIETARY_SUPPLEMENT: Soluble Corn Fiber|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Preventing Contrast Nephropathy With Sodium Bicarbonate in Patients With Pulmonary Edema,Heart Failure,Uncontrolled HTN
Status: COMPLETED
Conditions: Contrast Induced Nephropathy
Interventions: DRUG: Sodium Bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tolerability and Bioavailability of the P144 Peptide Inhibitor of TGF-β1 After Topical Administration in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: P144 cream|DRUG: P144 cream|DRUG: P144 cream|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Trial of Quercetin, Bromelain, Rye Flower Pollen & Papain on Reducing Severity of Radiation-Induced Prostatitis
Status: TERMINATED
Conditions: Prostate Adenocarcinoma
Interventions: DRUG: Q-Urol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Baricitinib in Participants With Systemic Lupus Erythematosus (SLE)
Status: TERMINATED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Baricitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Subthalamic and Nucleus Basalis Meynert Deep Brain Stimulation for Parkinson's Disease With Dementia
Status: UNKNOWN
Conditions: Parkinson Disease|Dementia
Interventions: DEVICE: Vercise deep brain stimulation|PROCEDURE: subthalamic nucleus (STN) stimulation|PROCEDURE: NBM stimulation|PROCEDURE: sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Detection of Annexin A2 in Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus (SLE)|Lupus Nephritis
Interventions: OTHER: ANXA2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intravitreal Ranibizumab Treatment of Central Serous Chorioretinopathy
Status: COMPLETED
Conditions: Central Serous Chorioretinopathy
Interventions: DRUG: rhuFab V2 [ranibizumab] ( Lucentis )
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy In Treating Patients With Advanced Cancer
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: gemcitabine hydrochloride|DRUG: leucovorin calcium|DRUG: tegafur-uracil
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparison Between Two Shock Wave Regimens for Treating Urinary Stones
Status: COMPLETED
Conditions: Urinary (Renal or Ureteral) Stones
Interventions: PROCEDURE: extracorporeal shockwave lithotripsy (SWL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measurement of Viral Load Reduction in the Oral Cavity After a Regimental Use of OC Toothpaste Products
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Colgate Total Clean Mint|DRUG: Tom's Botanically Bright Peppermint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Fimasartan on Extended RAS and Vascular Functions in Patients With Type 2 Diabetes and Hypertension
Status: RECRUITING
Conditions: Hypertension|Atherosclerosis|Diabetes Mellitus, Type 2|Renin Hypertension
Interventions: DRUG: Fimasartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A New Surgical Strategy to Protect the Inferior Parathyroid
Status: NOT_YET_RECRUITING
Conditions: Thyroid Cancer
Interventions: PROCEDURE: Resection based on "thymus-vascular-inferior parathyroid" complex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Shenfu Injection Improves Arterial Vascular Reactivity
Status: UNKNOWN
Conditions: Septic Shock|Shenfu|Vascular Reactivity
Interventions: DRUG: shenfu injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Obesity and Caries in Young South Asian Children: A Common Risk Factor Approach
Status: COMPLETED
Conditions: Pediatric Obesity|Early Childhood Caries
Interventions: BEHAVIORAL: Enhanced Usual Care (EUC)|BEHAVIORAL: Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Erdafitinib for the Treatment of Patients With Castration-Resistant Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Castration-Resistant Prostate Carcinoma|Castration-Resistant Prostate Carcinoma Refractory to Second-Generation Androgen Receptor Axis-Targeted Agents|Metastatic Malignant Neoplasm in the Bone|Metastatic Prostate Adenocarcinoma|Metastatic Prostate Small Cell Neuroendocrine Carcinoma|Stage IV Prostate Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8|Stage IVB Prostate Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Erdafitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recurrent Disease Detection After Resection of Pancreatic Adenocarcinoma Using a Standardized Surveillance Strategy
Status: UNKNOWN
Conditions: Resectable Pancreatic Ductal Adenocarcinoma|Recurrent Pancreatic Ductal Adenocarcinoma
Interventions: OTHER: Standardized surveillance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Endoscopic Injection Sclerotherapy Versus N-butyl-2-cyanoacrylate Injection
Status: UNKNOWN
Conditions: Bleeding Esophageal Varices
Interventions: DRUG: Injection Sclerotherapy|DRUG: N-butyl-2-cyanoacrylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Baclofen in the Treatment of Alcohol Dependence With or Without Alcoholic Liver Disease
Status: COMPLETED
Conditions: Alcoholic Liver Disease|Alcohol Dependence
Interventions: DRUG: Baclofen 30mg/day|DRUG: Baclofen 75mg/day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fractional Urate Excretion in Nonedematous Hyponatremia
Status: WITHDRAWN
Conditions: Cerebral Hyponatremia|SIADH|Cerebral Salt-wasting Syndrome|Reset Hypothalamic Osmostat
Interventions: DRUG: Tolvaptan in euvolemic hyponatremia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Primary Non-invasive Cardiac Computed Tomography Versus Routine Invasive Angiography Prior to TAVI
Status: UNKNOWN
Conditions: Severe Aortic Stenosis|Transcatheter Aortic Valve Implantation
Interventions: PROCEDURE: Selective invasive angiography based on CT/CCTA imaging.|PROCEDURE: Procedure/Surgery: Invasive angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Efficacy Evaluation of a Computer-aided Colonoscopy as Compared With the Standard Colonoscopy.
Status: RECRUITING
Conditions: Colon Adenoma|Colorectal Cancer
Interventions: DEVICE: "aetherAI" Computer-aided Polyp Detection (CADe) Systems for Colonoscopy|PROCEDURE: Standard colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Treatment of Relapsed or Refractory t(8; 21) AML With Targeted AML1-ETO Neoantigen Cytotoxic T Cells (CTL)
Status: RECRUITING
Conditions: AML|t(8;21)|Neoantigen
Interventions: BIOLOGICAL: targeted AML1-ETO neoantigen cytotoxic T cells (CTL)|DRUG: Cyclophosphamide injection|DRUG: Decitabine Injection|DRUG: Liposome mitoxantrone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT