pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: EPIC-HR: Study of Oral PF-07321332/Ritonavir Compared With Placebo in Nonhospitalized High Risk Adults With COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: PF-07321332|DRUG: Ritonavir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Entecavir Plus Adefovir Combination Therapy Versus Entecavir Monotherapy vs Therapy With Adefovir Plus Lamivudine for Chronic Hepatitis B Infected Subjects With Lamivudine-resistant Virus
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Entecavir|DRUG: Tenofovir|DRUG: Adefovir|DRUG: Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Into a New Diagnostic Tool (Simple Ultrasound-based Rules) in Patients With Adnexal Masses
Status: TERMINATED
Conditions: Ovarian Carcinoma|Ovarian Cancer|Ovarian Mass|Ovarian Cyst
Interventions: OTHER: Ultrasound by general gynaecologist|OTHER: Ultrasound by an expert ultrasonographist|OTHER: DW-MRI|OTHER: Give blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Temporary Clipping of the Uterine Arteries During Laparoscopic Myomectomy
Status: COMPLETED
Conditions: Leiomyoma|Laparoscopic Myomectomy
Interventions: PROCEDURE: clipping of uterine arteries during laparoscopic myomectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Efficacy of a Dietary Supplement on Parameters of Skin Aging in Men and Women
Status: COMPLETED
Conditions: Skin Aging
Interventions: DIETARY_SUPPLEMENT: HyaCera™|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Long-term Follow-up in Severe Traumatic Brain Injury
Status: RECRUITING
Conditions: Traumatic Brain Injury|Neurodegenerative Diseases|Chronic Traumatic Encephalopathy
Interventions: DIAGNOSTIC_TEST: Magnetic Resonance Imaging (MRI) (including functional MRI)|DIAGNOSTIC_TEST: Blood sampling (serum/plasma preparation)|DIAGNOSTIC_TEST: Cerebrospinal fluid (CSF)|DIAGNOSTIC_TEST: Clinical assessments / questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Etrasimod (APD334) in Patients With Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Etrasimod|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Tamoxifen Dose Escalation in Breast Cancer Patients With CYP2D6 Polymorphisms
Status: COMPLETED
Conditions: Breast Cancer|CYP2D6 Polymorphism
Interventions: DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Higher Dose of Rituxan Versus Standard Doses of Rituxan With Cyclophosphamide, Vincristine, and Prednisone in Subjects With Chronic ITP
Status: COMPLETED
Conditions: Immune Thrombocytopenic Purpura
Interventions: DRUG: Rituxan, Cyclophosphamide, Vincristine, Prednisone|DRUG: Higher Dose of Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: SU5416 Compared to Dexamethasone in Treating Patients With Progressive Prostate Cancer That Has Not Responded to Hormone Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: dexamethasone|DRUG: semaxanib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Retigabine Immediate Release as Adjunctive Therapy to Specified Monotherapy Antiepileptic Treatments in Adults With Partial-Onset Seizures
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Retigabine IR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (CSU)
Status: RECRUITING
Conditions: Chronic Spontaneous Urticaria
Interventions: BIOLOGICAL: barzolvolimab|BIOLOGICAL: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Effects, Safety and Tolerability of Cilobradine, Compared to Metoprolol Succinate and Placebo in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cilobradine low dose 1|DRUG: Cilobradine low dose 2|DRUG: Cilobradine medium dose|DRUG: Cilobradine high dose 1|DRUG: Cilobradine high dose 2|DRUG: Metoprolol succinate tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Nab-paclitaxel Based Regimens VS Paclitaxel Based Regimens in Neoadjuvant Treatment for TNBC
Status: WITHDRAWN
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Albumin bound (nab)-paclitaxel combined with carboplatin followed by epirubicin and cyclophosphamide|DRUG: paclitaxel combined with carboplatin followed by epirubicin and cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of Tramadol/Acetaminophen Versus Diclofenac in the Treatment of Pain in Participants With Ankylosing Spondylitis Receiving Stable Treatment of Disease Modifying Anti-rheumatic Drugs (DMARDs)
Status: TERMINATED
Conditions: Spondylitis, Ankylosing|Pain
Interventions: DRUG: Tramadol /acetaminophen|DRUG: Diclofenac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Obesity Surgery and Kidney Transplant for Patients With Obesity and Renal Failure
Status: ACTIVE_NOT_RECRUITING
Conditions: Severe Obesity|Renal Failure
Interventions: PROCEDURE: Gastric Bypass|OTHER: Weight Loss Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lidocaine Supplement for Minimal Invasive Parathyroid Surgery
Status: WITHDRAWN
Conditions: Parathyroid Disease
Interventions: DRUG: Lidocaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Intra-operative Photographs for the Assessment of a Proper Lymphadenectomy in Minimally-invasive Gastrectomies for Gastric Cancer (PhotoNodes)
Status: RECRUITING
Conditions: Gastric Cancer|Gastric Adenocarcinoma|Lymphadenectomy|Minimally Invasive Surgery|Gastrectomy for Gastric Cancer|Laparoscopic Surgery|Robotic Surgery|Survival Outcomes|Survival Analysis|Quality Of Care
Interventions: OTHER: Quality assessment of D2 lymphadenectomy using the PhotoNode Score
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy, Safety, and Pharmacodynamics of Tislelizumab Monotherapy and Multiple Tislelizumab-based Immunotherapy Combinations in Participants With Resectable Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Tislelizumab|DRUG: Ociperlimab|DRUG: LBL-007|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Pemetrexed|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing User Experience of Different Delivery Devices for Glucagon
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Nasal Glucagon Device (NG)|DEVICE: GEK|DRUG: IM Glucagon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bronchoscopy With Bronchoalveolar Lavage in Identifying Biomarkers of Response to Immune Checkpoint Inhibitors in Patients With Non-small Cell or Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-Small Cell Lung Carcinoma|Small Cell Lung Carcinoma
Interventions: PROCEDURE: Bronchoscopy with Bronchoalveolar Lavage|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: THE EFFECT OF tDCS IN THE TREATMENT OF CHRONIC PELVIC PAIN ASSOCIATED WITH ENDOMETRIOSIS
Status: UNKNOWN
Conditions: Chronic Pain|Endometriosis
Interventions: DEVICE: transcranial direct current stimulation (tDCS)|DEVICE: Sham Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Low GI/ Glycemic Load (GL) Diet in Diabetic Nephropathy Patients
Status: COMPLETED
Conditions: Diabetic Nephropathy|Medication Compliance
Interventions: OTHER: low GI|OTHER: low GI|OTHER: conventional diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess if a Medicine Called Bamlanivimab is Safe and Effective in Reducing Hospitalization Due to COVID-19
Status: UNKNOWN
Conditions: Covid19
Interventions: BIOLOGICAL: Bamlanivimab|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Genomic Laboratory Reports to Enhance Communication and Empower Patients
Status: COMPLETED
Conditions: Intellectual Disability|Autism|Multiple Congenital Anomalies
Interventions: OTHER: enhanced genomic report
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Efficacy of HLX208 (BRAF V600E Inhibitor) for Refractory Primary Brain Tumors With BRAF Mutation After First-line Treatment
Status: UNKNOWN
Conditions: Brain Tumor, Primary
Interventions: DRUG: HLX208
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of High Flow Nasal Oxygen During Sleep Endoscopy in Patients of Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: PROCEDURE: High-flow nasal oxygen|PROCEDURE: Low-flow nasal oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Additional Confirmatory Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)
Status: COMPLETED
Conditions: Spinocerebellar Degeneration
Interventions: DRUG: KPS-0373|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Carfilzomib, Lenalidomide, and Dexamethasone Re-induction Followed by the 2nd ASCT in Multiple Myeloma Patients Relapsed After the 1st ASCT
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Lenalidomide maintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Online Group-based Nonviolent Communication Interventions
Status: SUSPENDED
Conditions: Mild to Moderate Depressive Symptoms
Interventions: BEHAVIORAL: Online group nonviolent communication (NVC) interventions|OTHER: Waitlist control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intervention for Persons Leaving Residential Substance Abuse Treatment
Status: COMPLETED
Conditions: Substance Use Disorders
Interventions: BEHAVIORAL: Critical Time Intervention-Residential (CTI-R)|BEHAVIORAL: Enhanced Usual Discharge Services-Residential
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laryngoscope Asssited Lightwand Intubation
Status: UNKNOWN
Conditions: Cervical Spine Surgery
Interventions: PROCEDURE: Laryngoscope assisted lightwand intubation|PROCEDURE: Lightwand intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Efficiency and Response to 2.0 GBq (55mCi) 177Lu-EB-PSMA in Patients With mCRPC
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DRUG: 2.0 GBq of 177Lu-EB-PSMA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Red Blood Cells (RBC) Transfusion Related to Central Venous O2 Saturation (ScvO2) Measurement
Status: COMPLETED
Conditions: Postoperative Complications|Erythrocyte Transfusion|Oxygen Disorders
Interventions: PROCEDURE: Transfusion|PROCEDURE: Transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of IMC-18F1,to Treat Advanced Solid Tumors in Subjects That no Longer Respond to Standard Therapy
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: BIOLOGICAL: IMC-18F1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CBT4CBT for Office Based Buprenorphine
Status: COMPLETED
Conditions: Opioid-use Disorder
Interventions: BEHAVIORAL: CBT4CBT-Buprenorphine|DRUG: Buprenorphine/naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EXTENDed Antibiotic Durations Compared to Standard Durations for Patients With Complicated Intra-abdominal Infection.
Status: RECRUITING
Conditions: Complicated Intra-abdominal Infection
Interventions: DRUG: Antibiotic - standard duration|DRUG: Antibiotic - fixed-extended-duration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tamoxifen Therapy to Treat Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Hypertension|Pulmonary Arterial Hypertension|Familial Primary Pulmonary Hypertension|Primary Pulmonary Hypertension|Lung Diseases|Tamoxifen|Estrogen Receptor Antagonist|Hormone Antagonists|Estrogens
Interventions: DRUG: Tamoxifen|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CBT and the Neural Circuits of Anxiety
Status: RECRUITING
Conditions: Generalised Anxiety Disorder|Anxiety Disorders|CBT|Anxiety Depression|Anxiety Disorders and Symptoms|Anxiety Generalized|Anxiety|Anxiety Disorder Generalized|Anxiety Disorder; Mixed With Depression (Mild)
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy|OTHER: Waiting List
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Retrospective, Observational Chart Review Study Conducted in Poland to Document the Management and Clinical Outcome of CUVITRU and HYQVIA in Pediatric Participants (< 18 Years) With Primary Immunodeficiency (PID)
Status: COMPLETED
Conditions: Primary Immunodeficiencies (PID)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Paclitaxel Balloon Versus Standard Balloon in In-stent Restenoses of the Superficial Femoral Artery (PACUBA I Trial)
Status: UNKNOWN
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: drug eluting balloon angioplasty|DEVICE: standard balloon angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: De-escalation Immunotherapy mAintenance Duration Trial for Stage IV Lung Cancer Patients With Disease Control After Chemo-immunotherapy Induction
Status: RECRUITING
Conditions: Metastatic NSCLC
Interventions: DRUG: Pembrolizumab before randomization|DRUG: Chemotherapy|DRUG: Pemetrexed|DRUG: Pembrolizumab after randomization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GCS-100LE in Combination With Etoposide and Dexamethasone in Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Status: WITHDRAWN
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: GCS-100|DRUG: Etoposide; Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualized Assessment and Treatment for Alcoholism II
Status: COMPLETED
Conditions: Alcoholism
Interventions: BEHAVIORAL: Individualized Assess & Treatment (IATP)|BEHAVIORAL: Packaged Cognitive-Behavioral (PCBT)|BEHAVIORAL: Case Management (CaseM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NEUROIMPA - Intraarticular Application of Opioids in Chronic Arthritis of the Knee Joint
Status: UNKNOWN
Conditions: Knee Arthritis
Interventions: DRUG: Morphine Sulfate|DRUG: Triamcinolone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AZD5718 Phase IIa Study to Evaluate Efficacy, Safety and Tolerability of Oral AZD5718 in Patients With Coronary Artery Disease (CAD).
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: AZD5718|DRUG: AZD5718|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Tomographic and Genetic Aspects of Keratoconus Patients Compared to Sounds Corneas
Status: COMPLETED
Conditions: Keratoconus|Keratoconus, Unspecified, Bilateral
Interventions: OTHER: EVALUATION OF VSX1, SOD1, and TIMP3 genes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Pembrolizumab and Paricalcitol With or Without Chemotherapy in Patients With Pancreatic Cancer That Can Be Removed by Surgery
Status: COMPLETED
Conditions: Resectable Pancreatic Carcinoma|Stage I Pancreatic Cancer AJCC v6 and v7|Stage IA Pancreatic Cancer AJCC v6 and v7|Stage IB Pancreatic Cancer AJCC v6 and v7|Stage II Pancreatic Cancer AJCC v6 and v7|Stage IIA Pancreatic Cancer AJCC v6 and v7|Stage IIB Pancreatic Cancer AJCC v6 and v7
Interventions: DRUG: Gemcitabine Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Nab-paclitaxel|DRUG: Paricalcitol|BIOLOGICAL: Pembrolizumab|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of FAZ053 Single Agent and in Combination With PDR001 in Patients With Advanced Malignancies.
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumors|Triple Negative Breast Cancer|Chordoma and Alveolar Soft Part Sarcoma
Interventions: DRUG: FAZ053|DRUG: PDR001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Delayed Blood Stem Transplantation in HLA Matched Kidney Transplant Recipients to Eliminate Immunosuppressive Drugs.
Status: RECRUITING
Conditions: Immune Tolerance
Interventions: BIOLOGICAL: Hematopoietic cell transplantation|RADIATION: Total Lymphoid irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exergaming in People With Major Neurocognitive Disorder
Status: UNKNOWN
Conditions: Randomised Controlled Trial|Major Neurocognitive Disorder|Long-term Care Facility|Physical Activity|Cognitive Impairment
Interventions: DEVICE: Exergame device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of HMPL-306 in Advanced Solid Tumors With IDH Mutations
Status: ACTIVE_NOT_RECRUITING
Conditions: Isocitrate Dehydrogenase Gene Mutation
Interventions: DRUG: HMPL-306
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Use of 0.5 and 0.75 MAC Desflurane in Patients Undergoing Spinal Surgery
Status: UNKNOWN
Conditions: Anesthesia
Interventions: DRUG: 0.5 MAC desflurane|DRUG: 0.75 MAC desflurane|DRUG: 1.0 MAC desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Care Empowerment Program Using Virtual Reality for Family Caregivers of People With Dementia
Status: COMPLETED
Conditions: Dementia Family Caregiver
Interventions: OTHER: care empowerment program|OTHER: dementia education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Alvocidib, Cytarabine, and Mitoxantrone in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Secondary Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: alvocidib|DRUG: mitoxantrone hydrochloride|DRUG: cytarabine|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Dabigatran and Phenprocoumon on Clopidogrel Mediated ADP Induced Platelet Aggregation in Patients With Atrial Fibrillation
Status: TERMINATED
Conditions: Coronary Heart Disease|Atrial Fibrillation|Acute Coronary Syndrome|Atherosclerosis
Interventions: DRUG: Dabigatran|DRUG: Phenprocoumon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 131I-omburtamab Radioimmunotherapy for Neuroblastoma Central Nervous System/Leptomeningeal Metastases
Status: TERMINATED
Conditions: Neuroblastoma|CNS Metastases|Leptomeningeal Metastases
Interventions: BIOLOGICAL: 131I-omburtamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Enzyme Activity and Safety of Pancrelipase in Patients With Severe Exocrine Pancreatic Insufficiency (EPI)
Status: COMPLETED
Conditions: Exocrine Pancreatic Insufficiency|Pancreatitis, Chronic|Steatorrhea|Pancreatitis
Interventions: DIETARY_SUPPLEMENT: Ensure Plus|DRUG: Pancrelipase in combination with Ensure Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: |Primary Purpose:
Clinical trial: Etidronate for Arterial Calcifications Due to Deficiency in CD73 (ACDC)
Status: COMPLETED
Conditions: Arterial Calcification|CD73 Deficiency
Interventions: DRUG: Etidronate|DEVICE: MRI Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ASP2016 in Adults Who Have Heart Disease Associated With Friedreich Ataxia
Status: NOT_YET_RECRUITING
Conditions: Friedreich Ataxia|Cardiomyopathy
Interventions: GENETIC: ASP2016|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tamibarotene (OAM80) for Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer's Disease
Interventions: DRUG: Tamibarotene|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Miglustat / OGT 918 in the Treatment of Cystic Fibrosis
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DRUG: miglustat|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Examine the Effects of an Experimental Drug on Women With Breast Cancer and Metastatic Bone Disease (MBD)(0822-016)(COMPLETED)
Status: COMPLETED
Conditions: Breast Cancer|Metastatic Bone Disease
Interventions: DRUG: ZA|DRUG: Odanacatib|DRUG: Odanacatib matching placebo|DRUG: ZA matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn How Safe the Study Drug BAY 2416964 (AhR Inhibitor) in Combination With the Treatment Pembrolizumab is, How This Combination Affects the Body, the Maximum Amount That Can be Given, How it Moves Into, Through and Out of the Body and Its Action Against Advanced Solid Cancers in Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: BAY2416964|DRUG: BAY2416964|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Ranging Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Rectal Foam in Pediatric Patients Aged 5 to 17 Years With Active, Mild to Moderate Distal Ulcerative Colitis
Status: NOT_YET_RECRUITING
Conditions: Ulcerative Colitis
Interventions: DRUG: High dose budesonide rectal foam|DRUG: Low dose budesonide rectal foam|DRUG: Matching placebo rectal foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of an Infant Formula Containing Probiotic CECT7210 on Gastrointestinal Health
Status: COMPLETED
Conditions: Gastrointestinal Diseases
Interventions: DIETARY_SUPPLEMENT: Infant Formula with a novel probiotic CECT7210|DIETARY_SUPPLEMENT: Standard formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The PANTHERS (Parents and iNfants Together in Home-based Early Remote Services) Project
Status: RECRUITING
Conditions: Early Childhood Development|Behavior Problems
Interventions: BEHAVIORAL: Infant Behavior Program (IBP)|OTHER: Enhanced Pediatric Primary Care (EPPC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PET Trial to Evaluate Target Occupancy of CVL-231 on Brain Receptors Following Oral Dosing
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: CVL-231|DRUG: CVL-231|DRUG: CVL-231
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Antibiotics for the Treatment of Ulcerative Colitis
Status: COMPLETED
Conditions: Colitis, Ulcerative
Interventions: DRUG: Cefuroxime|DRUG: Ciprofloxacin|DRUG: Clarithromycin|DRUG: Cotrimoxazole|DRUG: Coamoxiclav|DRUG: metronidazole|DRUG: neomycin|DRUG: rifaximin|DRUG: Vancomycin|DRUG: Doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiopulmonary Function and Quality of Life in Pulmonary Tuberculosis
Status: RECRUITING
Conditions: Tuberculosis, Pulmonary|Physical Disability|Quality of Life
Interventions: OTHER: Physical rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Education in Patients With Chronic Obstructive Pulmonary Disease (COPD) - Effect and Costs
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: BEHAVIORAL: Group training with self-help group|BEHAVIORAL: Group training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Surgical Study Comparing 2 Procedures for the Treatment of a Dropped Bladder
Status: COMPLETED
Conditions: Prolapse
Interventions: PROCEDURE: anterior vaginal repair (colporrhaphy)|PROCEDURE: abdominal paravaginal defect repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Individualized Treatment Plan in Children and Young Adults With Relapsed Medulloblastoma
Status: RECRUITING
Conditions: Medulloblastoma|Medulloblastoma, Childhood|Medulloblastoma Recurrent
Interventions: OTHER: Specialized Tumor Board Treatment Plan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of Punctum Plug Delivery System in Subjects With Open-Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: Latanoprost-PPDS|DRUG: Latanoprost-PPDS|DRUG: Latanoprost-PPDS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Acceptability of an Internet-based Cognitive-behavioral Treatment for Insomnia in Adults With Asthma
Status: COMPLETED
Conditions: Asthma|Insomnia Chronic
Interventions: BEHAVIORAL: Internet-based CBT-I
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stroke and Traumatic Acute Brain Injury Line Indicator System for Emergent Recognition (STABILISER-I)
Status: COMPLETED
Conditions: Ischemic Stroke|Hemorrhagic Stroke|Traumatic Brain Injury
Interventions: DEVICE: Lateral Flow Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Efficacy of Methylene Blue for Malaria Treatment in Adults of Burkina Faso: Proof of Principle Study in Semi-Immune Adults of Burkina Faso in the Frame of the A8 Project of the SFB 544
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Methylenblue
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: BROnchoalveolar Investigations of Never-smokers With Chronic Obstruction From the Swedish CardioPulmonary bioImage Study
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease|Emphysema|Chronic Bronchitis|Airway Obstruction|Smoking, Tobacco|Gender
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CHFR Methylation Status Esophageal Cancer Study
Status: TERMINATED
Conditions: Esophageal Cancer
Interventions: DRUG: Paclitaxel|DRUG: Cisplatin|DRUG: Oxaliplatin|DRUG: 5-Fluorouracil|RADIATION: Radiotherapy|PROCEDURE: Esophagectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adding Cognitive Behavioral Therapy to Drug Treatment for Social Anxiety Disorder
Status: COMPLETED
Conditions: Social Anxiety Disorder
Interventions: DRUG: Paroxetine|BEHAVIORAL: Cognitive behavioral therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Microglial Activation in ALS With [18F]PBR06 (Peripheral Benzodiazepine Receptor-06) PET
Status: COMPLETED
Conditions: Healthy Volunteers|Amyotrophic Lateral Sclerosis
Interventions: DRUG: [18F]PBR06
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Comparison of Transcatheter Heart Valves in High Risk Patients With Severe Aortic Stenosis: The CHOICE Trial
Status: COMPLETED
Conditions: Aortic Stenosis
Interventions: PROCEDURE: Transcatheter Aortic Valve Implantation (TAVI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Increased Inflammation-resolving Activity by Omega-3 Monoglycerides in Peripheral Blood Mononuclear Cells (PBMC).
Status: RECRUITING
Conditions: Resolution of Inflammation|Reduction of Cell Proliferation
Interventions: OTHER: MAG-SPM treatment on isolated PBMC cells|OTHER: Isolated PBMC cells without treatment.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ICG-Enabled Mapping of Ovarian Sentinel Lymph Nodes: A Feasibility Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer|Adnexal Mass
Interventions: DRUG: Method 1: Indocyanine green dye|DRUG: Method 2: Indocyanine green dye|DRUG: Method 3: Indocyanine green dye|DRUG: Method 3: Indocyanine green dye
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Smartphone App on Activity
Status: UNKNOWN
Conditions: Diabetes Type 2|Hematologic Malignancy
Interventions: DEVICE: messages generated by learning algorithm|DEVICE: constant weekly message reminding patient to exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of a New Asthma Medicine in Asthmatics Whose Asthma Worsens With Exercise
Status: WITHDRAWN
Conditions: Asthma
Interventions: DRUG: Fluticasone Furoate/Vilanterol Inhalation Powder|DRUG: Fluticasone Propionate Inhalation Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radiosurgical Treatment for Obsessive-compulsive Disorder
Status: TERMINATED
Conditions: Obsessive-compulsive Disorder
Interventions: PROCEDURE: ventral capsular/ventral striatal gamma capsulotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Technology Assisted Cognitive Behavioural Therapy Intervention for Anxiety in People Living With Cognitive Impairment
Status: RECRUITING
Conditions: Dementia|Cognitive Impairment|Anxiety
Interventions: OTHER: Tech-CBT intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Therapy With Avonex and BiMonthly High Dose Intravenous Methotrexate in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: interferon beta 1a|DRUG: methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer
Status: COMPLETED
Conditions: Ovarian Sarcoma|Ovarian Stromal Cancer|Stage I Uterine Sarcoma|Stage I Vaginal Cancer|Stage I Vulvar Cancer|Stage IA Cervical Cancer|Stage IA Endometrial Carcinoma|Stage IA Fallopian Tube Cancer|Stage IA Ovarian Epithelial Cancer|Stage IA Ovarian Germ Cell Tumor|Stage IA Primary Peritoneal Cavity Cancer|Stage IB Cervical Cancer|Stage IB Endometrial Carcinoma|Stage IB Fallopian Tube Cancer|Stage IB Ovarian Epithelial Cancer|Stage IB Ovarian Germ Cell Tumor|Stage IB Primary Peritoneal Cavity Cancer|Stage IC Fallopian Tube Cancer|Stage IC Ovarian Epithelial Cancer|Stage IC Ovarian Germ Cell Tumor|Stage IC Primary Peritoneal Cavity Cancer|Stage II Endometrial Carcinoma|Stage II Gestational Trophoblastic Tumor|Stage II Uterine Sarcoma|Stage II Vaginal Cancer|Stage II Vulvar Cancer|Stage IIA Cervical Cancer|Stage IIA Fallopian Tube Cancer|Stage IIA Ovarian Epithelial Cancer|Stage IIA Ovarian Germ Cell Tumor|Stage IIA Primary Peritoneal Cavity Cancer|Stage IIB Cervical Cancer|Stage IIB Fallopian Tube Cancer|Stage IIB Ovarian Epithelial Cancer|Stage IIB Ovarian Germ Cell Tumor|Stage IIB Primary Peritoneal Cavity Cancer|Stage IIC Fallopian Tube Cancer|Stage IIC Ovarian Epithelial Cancer|Stage IIC Ovarian Germ Cell Tumor|Stage IIC Primary Peritoneal Cavity Cancer|Stage III Gestational Trophoblastic Tumor|Stage III Uterine Sarcoma|Stage III Vaginal Cancer|Stage III Vulvar Cancer|Stage IIIA Cervical Cancer|Stage IIIA Endometrial Carcinoma|Stage IIIA Fallopian Tube Cancer|Stage IIIA Ovarian Epithelial Cancer|Stage IIIA Ovarian Germ Cell Tumor|Stage IIIA Primary Peritoneal Cavity Cancer|Stage IIIB Cervical Cancer|Stage IIIB Endometrial Carcinoma|Stage IIIB Fallopian Tube Cancer|Stage IIIB Ovarian Epithelial Cancer|Stage IIIB Ovarian Germ Cell Tumor|Stage IIIB Primary Peritoneal Cavity Cancer|Stage IIIC Endometrial Carcinoma|Stage IIIC Fallopian Tube Cancer|Stage IIIC Ovarian Epithelial Cancer|Stage IIIC Ovarian Germ Cell Tumor|Stage IIIC Primary Peritoneal Cavity Cancer|Breast Cancer
Interventions: OTHER: behavioral, psychological or informational intervention|OTHER: behavioral, psychological or informational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of CMX-2043 in Subjects Undergoing Coronary Reperfusion Therapy
Status: COMPLETED
Conditions: Stable Coronary Artery Disease|Percutaneous Coronary Intervention
Interventions: DRUG: CMX-2043|DRUG: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diabetes em Movimento® - Community-based Lifestyle Intervention Program for Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Diabetes-Related Complications
Interventions: BEHAVIORAL: Exercise|BEHAVIORAL: Dietary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behaviour Therapy and Cognitive Training in Work Rehabilitation for Persons With Severe Mental Illness
Status: COMPLETED
Conditions: Mental Illness
Interventions: BEHAVIORAL: Work rehabilitation based on the cognitive therapeutical model|BEHAVIORAL: Work rehabilitation with the addition of cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Correlation Between Iodine and Selenium Status in Pregnancy and Risk of Thyroid Disease
Status: UNKNOWN
Conditions: Iodine Excess in Pregnancy|Selenium Excess in Pregnancy|Iodine Deficiency in Pregnancy|Selenium Deficiency in Pregnancy
Interventions: OTHER: Not applicable (for observational studies)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase III Study to Evaluate Safety and Effectiveness of NOVOCART 3D Plus vs. Microfracture in Knee Cartilage Defects
Status: COMPLETED
Conditions: Traumatic Articular Cartilage Defects in the Knee Joint
Interventions: DRUG: NOVOCART® 3D plus|PROCEDURE: Microfracture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simultaneous Versus Sequential Fractional CO2 Laser and Subcision Combination for Post-acne Atrophic Scars: A Split-face Comparative Study.
Status: COMPLETED
Conditions: Atrophic Acne Scar
Interventions: PROCEDURE: Simultaneous combination of fractional CO2 laser and subcision|PROCEDURE: Sequential combination of fractional CO2 laser and subcision|DEVICE: Fractional CO2 laser|PROCEDURE: Subcision|DRUG: Lidocaine/Prilocaine 2.5%-2.5% Topical Application Cream|DRUG: Paracetamol|DRUG: Lidocaine 2% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Exploring the Predictive Factors of TX and XELOX Regimen in the First Line Treatment of MGC
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: Docetaxol|DRUG: Oxaliplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability, and Plasma Concentration Study of Levodopa/Carbidopa Subcutaneous Solution (ND0612) in Parkinson's Disease (PD) Patients
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Levodopa/carbidopa solution for SC administration|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Fecal Microbiota Transplantation for Patients With Acute Graft-versus-Host Disease
Status: WITHDRAWN
Conditions: Fecal Microbiota Transplantation in Graft vs. Host Disease
Interventions: BIOLOGICAL: Autologous Fecal Microbiota Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Everolimus for Treatment of Disfiguring Cutaneous Lesions in Neurofibromatosis1 CRAD001CUS232T
Status: COMPLETED
Conditions: Neurofibromatosis 1
Interventions: DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact RTS,S/AS01 Vaccine in School Aged Children RTS,S/AS01 Malaria Vaccine in School Aged Children
Status: NOT_YET_RECRUITING
Conditions: Malaria,Falciparum
Interventions: BIOLOGICAL: Mosquirixs|DRUG: artemether-lumefantrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Acupressure, Laughter Yoga and Mindfulness on Menopausal Symptoms and Quality of Life
Status: UNKNOWN
Conditions: Menopausal Symptoms|Quality of Life
Interventions: OTHER: Acupressure, laughter yoga and mindfulness stress reduction program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Double-Blind, Randomized, Placebo-Controlled, Multicenter, Phase III Study of Tariquidar + Paclitaxel/Carboplatin as First-Line Therapy in Non-Small Cell Lung Cancer (NSCLC)
Status: TERMINATED
Conditions: Stage IIIb Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: PROCEDURE: Chemotherapy|DRUG: tariquidar + paclitaxel/carboplatin|DRUG: placebo + paclitaxel/carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose:
Clinical trial: Team-based Versus Primary Care Clinician-led Advance Care Planning in Practice-based Research Networks
Status: UNKNOWN
Conditions: Congestive Heart Failure|Cancer|Chronic Obstructive Pulmonary Disease|Cerebrovascular Accident|Frail Elderly Syndrome|Cardiovascular Diseases
Interventions: OTHER: Serious Illness Care Program (SICP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Impact of Exercise on Cognitive Impairment in End-Stage Renal Disease
Status: TERMINATED
Conditions: Cognitive Impairment|End-Stage Renal Disease
Interventions: OTHER: Aerobic Exercise|PROCEDURE: Standard Care Dialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Imaging Human Skin With High-Speed Spectrally Encoded Confocal Microscopy
Status: ENROLLING_BY_INVITATION
Conditions: Pigmented Lesions|Pigmented Skin Lesion|Pigmented Moles|Skin Lesion
Interventions: DEVICE: SECM Skin Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: An Open-Label Study to Evaluate the Effect of Every Other Week PROCRIT� (Epoetin Alfa) Dosing (40,000-60,000 Units) On Maintaining Quality of Life and Target Hemoglobin Levels in Anemic HIV-Infected Patients (CHAMPS II)
Status: COMPLETED
Conditions: Anemia|HIV Infections
Interventions: DRUG: Epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Volumetric Changes in Large Cystic Lesions Using Active Decompression and Distraction Sugosteogenesis vs Passive Decompression
Status: NOT_YET_RECRUITING
Conditions: Odontogenic Cysts
Interventions: DEVICE: Active decompression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY