pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Open-label Trial of Tofacitinib in Cutaneous Sarcoidosis and Granuloma Annulare
Status: COMPLETED
Conditions: Cutaneous Sarcoidosis|Granuloma Annulare
Interventions: DRUG: Tofacitinib 5 mg twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of HAART on Response to Hepatitis C Treatment in Patients Taking Peginterferon Alpha-2b and Ribavirin
Status: COMPLETED
Conditions: HIV Infections|Hepatitis C
Interventions: DRUG: highly active antiretroviral therapy (HAART)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Dovitinib Lactate, Gemcitabine Hydrochloride, and Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Advanced Solid Tumors or Pancreatic Cancer
Status: WITHDRAWN
Conditions: Duct Cell Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage III Pancreatic Cancer|Stage IV Pancreatic Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: dovitinib lactate|DRUG: gemcitabine hydrochloride|DRUG: paclitaxel albumin-stabilized nanoparticle formulation|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selenium in Mild Thyroid Eye Disease in North America
Status: WITHDRAWN
Conditions: Thyroid Associated Ophthalmopathies
Interventions: DRUG: Sodium selenate|DIETARY_SUPPLEMENT: Sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hepatic Artery Infusion of CD34+ Cells
Status: WITHDRAWN
Conditions: Stem Cell Transplantation|Liver Diseases
Interventions: PROCEDURE: Hepatic artery infusion of CD34+ cells|DEVICE: Cobe Spectra
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lung Function, Exercise Capacity, and Serology Responses in Patients With COVID-19
Status: RECRUITING
Conditions: Lung Function|Exercise Capacity|Quality of Life|Covid19
Interventions: BIOLOGICAL: third dose vaccination with CoronaVac vaccine|BIOLOGICAL: third dose vaccination with BionTech vaccine|BIOLOGICAL: Vaccination with Coronavac vaccine|BIOLOGICAL: Vaccination with BionTech Vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Empagliflozin as a Novel Therapy in Refractory Ascites
Status: COMPLETED
Conditions: Ascites Hepatic
Interventions: DRUG: Empagliflozin 10 MG|DRUG: Diuretics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: International Registration of Isolated STIC: to Report and Investigate the Risk of Serous Peritoneal Carcinomatosis
Status: NOT_YET_RECRUITING
Conditions: BRCA Mutation|Serous Tubal Intraepithelial Carcinoma|Ovarian Carcinoma|Peritoneal Carcinoma
Interventions: OTHER: No intervention, only registration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety of MK0928 on Insomnia in the Elderly (0928-005)(COMPLETED)
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: MK0928, gaboxadol|DRUG: Comparator: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nicotinamide Riboside as an Enhancer of Exercise Therapy in Hypertensive Older Adults (The NEET Trial)
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: Walking Exercise|DRUG: Nicotinamide Riboside (NR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Test Efficacy and Safety of Repeat Doses of CNTX-4975-05 in Patients With Osteoarthritis Knee Pain
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Placebo|DRUG: CNTX-4975-05
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vinorelbine/Gemcitabine Versus Vinorelbine/Cisplatin in Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Vinorelbine|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CYP1A2, ABCB1, CYP2C9 and Plasma Concentration of Agomelatine in Adult Patients With Depression
Status: NOT_YET_RECRUITING
Conditions: Polymorphism, Genetic|Depression|CYP1A2 Polymorphism|CYP2C9 Polymorphism|Polymerase Chain Reaction|Plasma Concentration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: FXR Effect on Severe Alcohol-Associated Hepatitis (FRESH) Study
Status: RECRUITING
Conditions: Alcohol Associated Hepatitis
Interventions: DRUG: INT-787|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Atazanavir/Ritonavir/Efavirenz as a Nucleoside Sparing Regimen
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Atazanvir/ritonavir + efavirenz|DRUG: Atazanvir/ritonavir + efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Safety and Effectiveness Evaluations of the COLO-BT as an Treatment to the Proctectomy.
Status: RECRUITING
Conditions: Colorectal Surgery|Colorectal Cancer|Rectal/Anal
Interventions: DEVICE: COLO BT™|OTHER: Stoma Creation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ONO-5920/YM529 Confirmatory Study in Involutional Osteoporosis Patients
Status: COMPLETED
Conditions: Osteoporosis|Bone Loss, Age-Related
Interventions: DRUG: YM529 / ONO-5920
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Low Amplitude Electroconvulsive Therapy
Status: TERMINATED
Conditions: Depression
Interventions: DEVICE: MECTA Spectrum 5000Q
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Inactivated Poliovirus Vaccine (IPV) With or Without E.Coli Double Mutant Heat-Labile Toxin (dmLT) Challenge Study in Healthy Adults
Status: COMPLETED
Conditions: Polio
Interventions: BIOLOGICAL: Inactivated Poliomyelitis Vaccine (IPV)|BIOLOGICAL: E.coli Double Mutant Heat-Labile Toxin (dmLT) (adjuvant)|BIOLOGICAL: Bivalent Oral Polio Vaccine (bOPV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: RO4929097 in Treating Patients With Recurrent and/or Metastatic Epithelial Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Stage IV Fallopian Tube Cancer|Stage IV Ovarian Cancer|Stage IV Primary Peritoneal Cancer
Interventions: DRUG: Gamma-Secretase Inhibitor RO4929097|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Blood Levels and Safety of Olaparib in Patients With Advanced Solid Tumours and Normal Liver Function or Mild or Moderate Liver Impairment
Status: COMPLETED
Conditions: Solid Tumours
Interventions: DRUG: Olaparib tablet dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Pain Squad+ Smartphone App To Support Real-Time Pain Management for Adolescents With Cancer
Status: RECRUITING
Conditions: Therapy-Associated Cancer
Interventions: OTHER: Pain Squad+ with Nurse Support|OTHER: Pain Squad+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Lowering Viral Load With Nucleos(T)Ide Analogues Prior to Peginterferon Treatment to Ncrease Sustained Response in CHB
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: PegIFN alfa-2b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Impact of B Vitamin Supplementation (Soloways™) on Homocysteine and LDL-C Levels in Patients With MTHFR, MTR, and MTRR Polymorphisms.
Status: COMPLETED
Conditions: Hyperhomocysteinemia|Hyperlipoproteinemias
Interventions: DIETARY_SUPPLEMENT: Vitamin B|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Anlotinib Hydrochloride Capsules Combined With CAPEOX in RAS and BRAF Wild-type mCRC Patients
Status: COMPLETED
Conditions: Colorectal Cancer|RAS and BRAF Wild-type|Colorectal Neoplasms|Intestinal Neoplasms|Gastrointestinal Neoplasms|Digestive System Neoplasms|Neoplasms by Site|Neoplasms|Digestive System Diseases|Gastrointestinal Diseases|Colonic Diseases|Intestinal Diseases|Rectal Diseases
Interventions: DRUG: Anlotinib Hydrochloride|DRUG: Capecitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Group Clinical Visit Adherence Intervention for HIV+ Women of Color
Status: TERMINATED
Conditions: Adherence, Patient|HIV/AIDS|Group Meetings
Interventions: BEHAVIORAL: Sisters-GPS: Group Clinical Visits|BEHAVIORAL: Control: One-on-one Adherence Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy, Metabolism and BMD of the 3-month TP Compared to the 1-month TP in ICPP
Status: NOT_YET_RECRUITING
Conditions: Central Precocious Puberty
Interventions: DRUG: Triptorelin pamoate（15mg）|DRUG: Triptorelin acetate （3.75mg）
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy and Sargramostim in Treating Patients With Stage IV Malignant Melanoma
Status: COMPLETED
Conditions: Recurrent Melanoma|Stage IV Melanoma
Interventions: BIOLOGICAL: tyrosinase peptide|BIOLOGICAL: MART-1:27-35 peptide vaccine|BIOLOGICAL: gp100 antigen|BIOLOGICAL: incomplete Freund's adjuvant|BIOLOGICAL: sargramostim|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modeling, Optimization, and Control Methods for a Personalized Hybrid Walking Exoskeleton
Status: UNKNOWN
Conditions: Spinal Cord Injuries|Paraplegia, Spinal|Paraplegia, Incomplete
Interventions: DEVICE: Exoskeleton Walking - with or without FES|DEVICE: Exoskeleton Sitting to Standing - with or without FES
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Biologic Onset of Crohn's Disease: A Screening Study in First Degree Relatives
Status: TERMINATED
Conditions: Crohn Disease|Genetic Predisposition|IBD
Interventions: DEVICE: Capsule endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Tolerability of a Cell-Derived Influenza Vaccine in Healthy Adults Aged ≥18 Years and ≤ 49 Years
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Seasonal cell-derived influenza vaccine|BIOLOGICAL: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Efficacy and Safety of Baxdrostat in Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension
Status: RECRUITING
Conditions: Uncontrolled Hypertension|Resistant Hypertension
Interventions: DRUG: Baxdrostat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: the Role of ctDNA in Predicting the Recurrence Risk of Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer Stage II|Colorectal Cancer Stage III
Interventions: PROCEDURE: Chemotherapy time|PROCEDURE: Chemotherapy time
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Trial of Iloprost in Pulmonary Hypertension Secondary to Pulmonary Fibrosis
Status: UNKNOWN
Conditions: Pulmonary Fibrosis|Pulmonary Hypertension
Interventions: DRUG: Iloprost inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neural Mechanism of Aldosterone-induced Insulin Resistance
Status: WITHDRAWN
Conditions: Hypertension
Interventions: DRUG: DEFINITY® infusion|DRUG: Human Recombinant Regular Insulin infusion|DRUG: Dextrose infusion|PROCEDURE: Flow mediated vasodilation|PROCEDURE: Endothelial cell collection|PROCEDURE: Microvascular perfusion assessment using Definity|PROCEDURE: Microneurography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neuroprotection With Riluzole Patients With Early Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Avonex (Interferon beta 1a)|DRUG: Riluzole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Long Term Safety, Tolerability, and Effectiveness of Olesoxime in Patients With Spinal Muscular Atrophy (SMA)
Status: COMPLETED
Conditions: Muscular Atrophy, Spinal
Interventions: DRUG: Olesoxime
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Hypoallergenicity of a New Amino-acid Based Infant Formula in Children With Cow's Milk Allergy
Status: COMPLETED
Conditions: Cow's Milk Allergy
Interventions: OTHER: New Amino Acid formula|OTHER: Commercially available Amino Acid Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Megestrol Acetate Plus Rosuvastatin in Young Women With Early Endometrial Carcinoma
Status: RECRUITING
Conditions: Endometrial Carcinoma Stage I
Interventions: DRUG: Megestrol Acetate|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of a Wireless Monitoring Device to Reduce Falls in the Elderly and Others at High Risk of Falling
Status: COMPLETED
Conditions: Accidental Falls|Fractures|Injuries
Interventions: DEVICE: FallSaver (formerly called NOCwatch)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The GATE Trial: Endoscopic Sutured Gastroplasty in Type 2 Diabetic, Obese Patients Using the Endomina Device
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus Type 2 in Obese
Interventions: DEVICE: Endoscopic sutured gastroplasty with endomina
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess and Compare the Efficacy of Cyclosporine Versus Azathioprine in the Treatment of Chronic Refractory Urticaria
Status: COMPLETED
Conditions: Chronic Refractory Urticaria
Interventions: DRUG: cyclosporine vs azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Loteprednol vs Prednisolone for the Treatment of Intraocular Inflammation Following Cataract Surgery in Children.
Status: COMPLETED
Conditions: Cataract
Interventions: DRUG: Loteprednol etabonate|DRUG: Prednisolones acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose-escalation Study to Evaluate the Safety and Clinical Activity of PBCAR269A, With or Without Nirogacestat, in Study Participants With Relapsed/Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Relapsed/Refractory Multiple Myeloma
Interventions: GENETIC: PBCAR269A|DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Nirogacestat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability, Efficacy and Exposure Study of XEN801 Topical Gel
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: XPF-005|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TACE+Tilelizumab+Sorafenib in the Treatment of BCLC Stage C HCC
Status: RECRUITING
Conditions: BCLC Stage C Hepatocellular Carcinoma
Interventions: PROCEDURE: TACE|DRUG: Tilelizumab|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post Stroke Motor Learning
Status: SUSPENDED
Conditions: Stroke|Hemiparesis
Interventions: DEVICE: transcranial direct current stimulation tDCS|DEVICE: transcranial magnetic stimulation TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Pharmacokinetics of IMP4297 in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumours|Breast Cancer|Ovarian Cancer|Prostate Cancer|Primary Peritoneal Cancer
Interventions: DRUG: IMP4297
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LiverPAL: A Pilot Study of Inpatient Palliative Care for Patients With Advanced Liver Disease
Status: COMPLETED
Conditions: Cirrhosis, Liver
Interventions: BEHAVIORAL: LiverPal Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomized, Double-Blind, Trial Comparing Epinephrine Versus Phenylephrine as a Vasoconstrictor in Regional Anesthesia for Upper Extremity Surgery
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Epinephrine/phenylephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: A Clinical Study to Evaluate the Safety and Immunogenicity of the Recombinant COVID-19 Vaccine (Sf9 Cell) as a Booster
Status: COMPLETED
Conditions: COVID-19|SARS-CoV-2 Infection
Interventions: BIOLOGICAL: Recombinant COVID-19 Vaccine (Sf9 Cell)|BIOLOGICAL: COVID-19 Vaccine (Vero Cell), Inactivated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Incentives, Cognitive Training and Internet Therapy for Teens With Poorly Controlled Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: BEHAVIORAL: MAxIM|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Glyaderm Clinical Evaluation Multicenter Study
Status: TERMINATED
Conditions: Full-thickness Skin Loss Due to Burn, Unspecified Site
Interventions: PROCEDURE: Glyaderm|PROCEDURE: STSG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of CHS-114 in Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: CHS-114|DRUG: toripaliamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Pharmacokinetics of ATL-001 (Ciclopirox Olamine) in Healthy Volunteers
Status: COMPLETED
Conditions: Adverse Effect of Drugs and Medicaments in Therapeutic Use
Interventions: DRUG: Ciclopirox Olamine Oral|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety Study for Intravenous (IV) AC480 (AC480IV) to Treat Advanced Solid Tumors
Status: WITHDRAWN
Conditions: Solid Tumors
Interventions: DRUG: AC480IV|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone and Muscle Health in Kids
Status: COMPLETED
Conditions: Skeletal Disorder
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol (vitamin D3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Model-informed Patient-specific Rehabilitation Using Robotics and Neuromuscular Modeling
Status: RECRUITING
Conditions: Stroke
Interventions: BEHAVIORAL: Belt Accelerations|BEHAVIORAL: Belt accelerations combined with an exoskeleton|BEHAVIORAL: Variable Stiffness treadmill
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Olive Oil and Cardiovascular Health
Status: WITHDRAWN
Conditions: Cardiovascular Disease|Endothelial Function
Interventions: DIETARY_SUPPLEMENT: Hydroxytyrosol, the active ingredient in olive oil.|DIETARY_SUPPLEMENT: Placebo|BEHAVIORAL: Nutrition counseling|DEVICE: Endopat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of GnRH Agonist vs GnRH Antagonist on IVF/ICSI Outcomes.
Status: COMPLETED
Conditions: In Vitro Fertilization|Intracytoplasmic Sperm Injection|Infertility
Interventions: DRUG: Triptorelin acetate|DRUG: Cetrorelix|DRUG: recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin|DRUG: Human Chorionic Gonadotropin (hCG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of a Vaginal Ring With Meloxicam on Ovarian Cycle in Fertile Women
Status: COMPLETED
Conditions: Contraception|Bleeding Pattern
Interventions: DRUG: Meloxicam 2.4 g|DRUG: Meloxicam 3.0 g
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Abuse Liability of Reduced Nicotine Content Cigarettes Within a Complex Tobacco Marketplace
Status: COMPLETED
Conditions: Substance-Related Disorders
Interventions: DRUG: SPECTRUM cigarettes|DRUG: SPECTRUM cigarettes between
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cohort Study to Determine the Long-Term Safety and Efficacy of Biogeneric Epoetin Treatment for Renal Anemia
Status: UNKNOWN
Conditions: Chronic Kidney Disease|End-Stage Renal Failure|Anaemia
Interventions: DRUG: Biogeneric Epoetin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Interactive Obesity Treatment Approach for Obesity Prevention in Adults With Early Serious Mental Illness: iOTA-SMI
Status: UNKNOWN
Conditions: Obesity|Overweight|Severe Mental Disorder
Interventions: BEHAVIORAL: iOTA text messaging intervention|BEHAVIORAL: Health Education text messaging intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Bupivacaine Versus Bupivacaine for for Postoperative Pain Control in Shoulder Surgery
Status: COMPLETED
Conditions: Anesthesia, Local
Interventions: DRUG: interscalene nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lipopolysaccharide Metabolism and Identification of Potential Biomarkers Predictive of Graft-versus-host Disease After Allogeneic Stem Cell Transplantation
Status: UNKNOWN
Conditions: Hematologic Diseases|Stem Cell Transplantation
Interventions: OTHER: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of AQX-1125 in IC/BPS
Status: COMPLETED
Conditions: Interstitial Cystitis|Bladder Pain Syndrome
Interventions: DRUG: AQX-1125|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Rifaximin vs Norfloxacin for Secondary Prophylaxis of SBP (NORRIF Trial)
Status: NOT_YET_RECRUITING
Conditions: Spontaneous Bacterial Peritonitis
Interventions: DRUG: Rifaximin|DRUG: Norfloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Observational Cohort Study to Assess the Postop Activity of Colorectal Patients Undergoing Elective Surgery (PHYSPAL)
Status: NOT_YET_RECRUITING
Conditions: Colorectal (Colon or Rectal) Cancer
Interventions: DEVICE: ActivPAL accelerometer|OTHER: Hospital Anxiety and Depression Scale (HADS) Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nickel Sensitivity
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee Arthropathy|Allergic Reaction
Interventions: DEVICE: TKA with nickel free components|DEVICE: TKA with standard cobalt chromium components
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Immune Activation in HIV-1 Infected Patients Under AntiRetroviral Treatment
Status: COMPLETED
Conditions: Immune Deficiency|HIV-related Gut Disease - Cause Unknown|Activation of Latent Virus|Other Diagnoses, Comorbidities, and Complications
Interventions: BIOLOGICAL: Blood test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prospective Comparison of Primary Abdominal Closure and Vacuum Assisted Laparostomy in Treatment of Severe Peritonitis
Status: COMPLETED
Conditions: Peritonitis
Interventions: DEVICE: V.A.C.- Vacuum assisted closure laparostomy (KCI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Electroretinogram and Contrast Sensitivity After PASCAL Treatment
Status: TERMINATED
Conditions: Non Proliferative Diabetic Retinopathy|Proliferative Diabetic Retinopathy
Interventions: PROCEDURE: PASCAL laser treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rate Adaptive Atrial Pacing in Heart Failure
Status: UNKNOWN
Conditions: Chronotropic Incompetence|Heart Failure|ICD
Interventions: DEVICE: AAIR pacing|DEVICE: DDI-pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Relationship of Trunk Position Sense and Spinal Posture With Balance in Parkinson's
Status: COMPLETED
Conditions: Parkinson Disease|Postural Kyphosis, Lumbosacral Region|Postural Kyphosis|Postural Lordosis, Lumbosacral Region|Balance; Distorted
Interventions: DEVICE: Spinal Mouse and Digital Inclinometer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nonmyeloablative Conditioning for Mismatched Hematopoietic Stem Cell Transplantation for Severe Sickle Cell Disease
Status: TERMINATED
Conditions: Sickle Cell Disease
Interventions: DRUG: Alemtuzumab|DRUG: Cyclophosphamide|DRUG: Mycophenolate mofetil|DRUG: Sirolimus|DRUG: Fludarabine|RADIATION: Total body irradiation|PROCEDURE: Hematopoietic stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Hip Strengthening Exercises on Walking Patterns and Muscle Strength in Persons With Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: BEHAVIORAL: home exercise program for the hip abductor muscles
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Balance in Children With Cochlear Implants
Status: COMPLETED
Conditions: Severe, Profound Deafness
Interventions: BEHAVIORAL: Evaluation of motor proficiency skills.|BEHAVIORAL: Evaluation of motor proficiency|BEHAVIORAL: Evaluation of motor proficiency|BEHAVIORAL: Evaluation of motor proficiency.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TLH With Prior Uterine Artery Clipping at Its Origin Versus Conventional TLH
Status: UNKNOWN
Conditions: Total Laparoscopic Hysterectomy
Interventions: PROCEDURE: Conventional TLH|PROCEDURE: Clipping of utrine artery at its origin before bginning of TLH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of TAS-102 or Placebo Plus BSC in Patients With Metastatic Gastric Cancer
Status: COMPLETED
Conditions: Refractory Metastatic Gastric Cancer
Interventions: DRUG: TAS-102|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-operative Dental Pain Study Comparing Two Different Dosage of Analgesic Efficacy
Status: COMPLETED
Conditions: Post-surgical Dental Pain
Interventions: DRUG: Paracetamol 1000 mg|DRUG: Paracetamol 650 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Conditions of Diagnostic Panendoscopy of the Upper Airway Under Propofol Remifentanil General Anesthesia
Status: COMPLETED
Conditions: Tumor of Ear, Nose and Throat
Interventions: DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Memantine on Cognitive Impairment in Patients With Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Memantine Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: SLPI for Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer|Prostatic Neoplasm
Interventions: DIAGNOSTIC_TEST: Secretory leukocyte protease inhibitor (SLPI) in prostate cancer|DIAGNOSTIC_TEST: Determination of molecular alterations|DIAGNOSTIC_TEST: Secretory leukocyte protease inhibitor (SLPI) Healthy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Oral Choline Supplementation on Postoperative Pain
Status: COMPLETED
Conditions: Postoperative Pain|Inflammation
Interventions: DRUG: Choline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Minimum Flow and Low Flow Desflurane Anesthesia in Robotic Assisted Laparoscopic Abdominal Surgery
Status: NOT_YET_RECRUITING
Conditions: Minimal Flow Anesthesia|Low Flow Anesthesia|Robotic Assisted Laparoscopic Abdominal Surgery
Interventions: OTHER: blood gas analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ketamine vs Hydromorphone
Status: COMPLETED
Conditions: Laparoscopic Gastric Bypass|Obesity|Pain, Postoperative
Interventions: DRUG: Ketamine|DRUG: Narcotics|BEHAVIORAL: pain scale
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Vitamin D and Inflammatory Markers of Cardiovascular Disease in African Americans With Type 2 Diabetes
Status: UNKNOWN
Conditions: Vitamin D Deficiency|Diabetes
Interventions: DRUG: Ergocalciferol|DRUG: Placebo pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Roux-En-Y Pouch Reconstruction Compared With Conventional Roux-En-Y Reconstruction on Quality of Life in Patients Undergoing Total Gastrectomy
Status: UNKNOWN
Conditions: Gastric Tumor
Interventions: PROCEDURE: Roux-En-Y Pouch Reconstruction or Conventional Roux-En-Y Reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comfort Survey of Open-angle Glaucoma or Ocular Hypertension Patients Treated With 2 Drugs
Status: COMPLETED
Conditions: Open-angle Glaucoma|Ocular Hypertension
Interventions: DRUG: timolol hemihydrate|DRUG: timolol maleate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Deep Brain Stimulation in Treatment Refractory Depression
Status: TERMINATED
Conditions: Major Depressive Disorder
Interventions: DEVICE: ITP Stimulation|DEVICE: CI/BNST stimulation|DEVICE: No stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeting Inflammation Using Salsalate for Type 2 Diabetes-Stage II
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Salsalate|DRUG: Salsalate Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Trunk Exercise on Trunk Control and Balance in Persons With Stroke
Status: COMPLETED
Conditions: Cerebrovascular Accident|Balance Impairment
Interventions: OTHER: trunk exercise on unstable exercise|OTHER: Upper limb range of motion exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repeated Methotrexate for Proliferative Vitreoretinopathy Grade C
Status: UNKNOWN
Conditions: Proliferative Vitreoretinopathy
Interventions: DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Physiotherapeutic Scoliosis Specific Exercises in Adolescent Idiopathic Scoliosis
Status: UNKNOWN
Conditions: Scoliosis Idiopathic Adolescent
Interventions: OTHER: physiotherapeutic scoliosis specific exercises|OTHER: generalised physiotherapy exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Tiotropium Inhalation Capsules and Atrovent Metered Dose Inhaler (MDI) in a Efficacy and Safety Study in Adults With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: tiotropium inhalation powder capsules|DRUG: Atrovent|DRUG: placebo to Atrovent|DRUG: placebo to tiotropium inhalation capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Trial of PROSCAR (Finasteride) Versus Placebo in Men With an Initial Negative Prostate Biopsy
Status: COMPLETED
Conditions: Enlarged Prostate
Interventions: DRUG: Finasteride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Chiauranib in Combination With Chidamide in Patients With Relapsed/Refractory Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-hodgkin's Lymphoma
Interventions: DRUG: Chiauranib|DRUG: Chidamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot the Use of VA Make the Connection Campaign to Facilitate Help Seeking Among Vulnerable Veterans
Status: WITHDRAWN
Conditions: Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)|Help-Seeking Behavior
Interventions: OTHER: Exposure to Make the Connection messages|OTHER: Active Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluate the Efficacy and Safety of Intense Pulsed Light Filters Combined With Oral Medication in the Treatment of Acne
Status: UNKNOWN
Conditions: Acne Vulgaris
Interventions: DRUG: Minocycline hydrochloride capsules were taken orally
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Intradetrusor AbobotulinumtoxinA and IncobotulinumtoxinA in Women With Overactive Bladder
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: AbobotulinumtoxinA 300 UNT|DRUG: IncobotulinumtoxinA 100 UNT|DRUG: Lidocain|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: To Assess the Efficacy and Safety of INCB054707 in Participants With Hidradenitis Suppurativa
Status: COMPLETED
Conditions: Hidradenitis Suppurativa|Acne Inversa
Interventions: DRUG: INCB054707|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ICE: Intracardiac Ultrasound Within the Left Atrium During Radiofrequency Ablation of Nonvalvular Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Biosense Webster irrigated tip catheter|DEVICE: Biosense Webster irrigated tip catheter|PROCEDURE: Pulmonary vein isolation|PROCEDURE: ICE catheter placed through one of two existing 8F sheaths
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Lenvatinib in Patients With Brain Metastases From Melanoma or Renal Cell Carcinoma
Status: RECRUITING
Conditions: Melanoma|Renal Cell Carcinoma|Brain Metastases|PD1/PD-L1 Experienced|Pembrolizumab|Lenvatinib|Metastatic Melanoma
Interventions: DRUG: Pembrolizumab|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Sodium Pyruvate for the Treatment of Cystic Fibrosis.
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Sodium Pyruvate in 0.9% Sodium Chloride Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Ipilimumab, Nivolumab, and Cabozantinib in Patients With Cutaneous Melanoma
Status: COMPLETED
Conditions: Refractory Cutaneous Melanoma
Interventions: DRUG: Ipilimumab|DRUG: Nivolumab|DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Brain Stimulation for Pain Relief
Status: UNKNOWN
Conditions: Pain, Acute|Pain, Chronic|Pain, Experimental
Interventions: OTHER: Transcranial Focused Ultrasound|OTHER: Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: G-CSF Versus G-CSF Plus GM-CSF for Stem Cell Mobilization in NHL Patients
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Etoposide|DRUG: G-CSF|DRUG: GM-CSF|DRUG: Isophosphamide|DRUG: Rituximab|PROCEDURE: Apheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Timing of Endoscopic Intervention for Acute Variceal Hemorrhage: an RCT
Status: RECRUITING
Conditions: Acute Upper Gastrointestinal Hemorrhage|Cirrhosis|Varice Bleed|Gastroesophageal Varices
Interventions: OTHER: endoscopic intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Immunogenicity and Safety of MVC-COV1901 Vaccine Compared With AZD1222
Status: COMPLETED
Conditions: COVID-19 Vaccine
Interventions: BIOLOGICAL: MVC-COV1901|BIOLOGICAL: AZD1222
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Subcutaneous Campath-1H in Patients With B-Cell CLL and Residual Disease After Chemotherapy
Status: UNKNOWN
Conditions: B-Cell Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: Alemtuzumab (Campath-1H)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS)
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Texas Childhood Obesity Research Demonstration (TX CORD) Project
Status: COMPLETED
Conditions: Childhood Obesity
Interventions: BEHAVIORAL: BMI screening|BEHAVIORAL: Next Steps brief clinical intervention|BEHAVIORAL: MEND/CATCH|BEHAVIORAL: MEND/CATCH Transition Phase|BEHAVIORAL: Next Steps Self-Paced Booklet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cumulative Live Birth Rates After Cleavage-stage Versus Blastocyst-stage Embryo Transfer
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: blastocyst-stage embryo transfer|PROCEDURE: cleavage-stage embryo transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile and Remote Monitoring of Seating Pressure for Wheelchair Users With SCI
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: BEHAVIORAL: Structured Pressure Ulcer Prevention Education|OTHER: Mobile Seat Interface Pressure Mapping System (IPM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Chlorhexidine-Alcohol Versus Povidone Iodine-Alcohol, Combined or Not With Use of a Bundle of New Devices, for Prevention of Intravascular-catheter Colonization and Catheter Failure
Status: COMPLETED
Conditions: Intravascular-catheter Colonization|Catheter Failure
Interventions: DRUG: Povidone-Iodine-Alcohol|DRUG: Chlorhexidine-Alcohol|DEVICE: Insyte Autoguard BC Winged|DEVICE: Nexiva single port catheter, MaxZero needless connector, PureHub Deinfecting Caps and Posiflush prefilled saline syringes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Obscure Gastrointestinal Bleeding Patients With Conventional Capsule Endoscopy and Panoramic Side View Capsule Endoscopy
Status: UNKNOWN
Conditions: Capsule Endoscopes
Interventions: DEVICE: Capsule endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas
Status: COMPLETED
Conditions: Diffuse Intrinsic Pontine Glioma|Diffuse Pontine and Thalamic Gliomas|Diffuse Midline Glioma
Interventions: DRUG: Infusate with MTX110 and gadolinium|DEVICE: Convection-Enhanced Delivery (CED)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Two Versus Three Active MDMA-assisted Sessions in U.S. Military Veterans With Chronic PTSD
Status: ACTIVE_NOT_RECRUITING
Conditions: PTSD
Interventions: DRUG: Midomafetamine|BEHAVIORAL: Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT