pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Modified MRCUKALLⅫ/ECOGE2993 Regimen for ALL
Status: UNKNOWN
Conditions: Leukaemia,Lymphoblastic
Interventions: DRUG: Vincristine|DRUG: Daunorubicin|DRUG: Pegaspargase|DRUG: Prednisone|DRUG: Intrathecal Methotrexate|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: 6-Mercaptopurine|DRUG: Methotrexate|DRUG: Etoposide|DRUG: dexamethasone|DRUG: thioguanine|DRUG: intrathecal cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robotic Surgery of the Ocular Surface
Status: TERMINATED
Conditions: Keratitis|Pterygium|Corneal Opacity Corneal Thinning|Corneal Perforation
Interventions: DEVICE: 1. Amniotic membrane transplantation on the cornea with the Da Vinci Si HD© robot (Inlay or overlay technique)|DEVICE: Pterygium removal and autograft of the conjunctiva with the Da Vinci Si HD© robot (Kenyon technique)|DEVICE: Penetrating keratoplasty using Baron trephine and nylon stitches with the Da Vinci Si HD© robot
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes Failing on OADs
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart 30
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Respiratory Rehabilitation After COVID-19 Severe Infection
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19 Respiratory Infection|Rehabilitation|Physical Therapists
Interventions: OTHER: Interval training + analytical strength|OTHER: Interval training + analytical strength and IMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Efficacy of Panobinostat in Participants With Primary Myelofibrosis
Status: TERMINATED
Conditions: Primary Myelofibrosis|Post-Polycythemia Vera|Post-Essential Thrombocytopenia
Interventions: DRUG: Panobinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selective Lasertrabeculoplasty and Ocular Hemodynamics in Glaucoma
Status: COMPLETED
Conditions: Glaucoma
Interventions: PROCEDURE: Selective Laser Trabeculoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conventional Coronectomy vs Coronectomy in Combination Vital Pulp Treatment Using Calcium Silicate
Status: COMPLETED
Conditions: Impacted Third Molar Tooth
Interventions: PROCEDURE: Coronectomy|PROCEDURE: Pulp Capping with calcium silicate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Orexin System on Nicotine Addiction and Its Neural Mechanism
Status: NOT_YET_RECRUITING
Conditions: Tobacco Use Disorder
Interventions: BEHAVIORAL: extinction training (nicotine cues)|BEHAVIORAL: extinction training (neutral cues)|BEHAVIORAL: Time-restricted smoking cessation|BEHAVIORAL: Time-restricted fasting|BEHAVIORAL: Time-restricted fasting with food supplemnet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of Trametinib and Azacitidine for Patients With Newly Diagnosed Juvenile Myelomonocytic Leukemia
Status: RECRUITING
Conditions: Leukemia, Juvenile Myelomonocytic|JMML|JCML|Neurofibromatosis 1|CBL Syndrome
Interventions: DRUG: Trametinib|DRUG: Azacitidine|DRUG: Fludarabine|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRI Study of the Distal Radius Bone Marrow Fat Fraction in Osteoporotic and Healthy Women
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal
Interventions: DEVICE: MRI scans of distal radius
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Effectiveness of Juveena™ Hydrogel System Following TCGP At High-Risk for Intrauterine Adhesions
Status: RECRUITING
Conditions: Intrauterine Adhesion
Interventions: DEVICE: Juveena Hydrogel System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Durvalumab Combined With Surufatinib as Maintenance Therapy in Patients With Advanced Biliary Tract Cancer
Status: NOT_YET_RECRUITING
Conditions: Biliary Tract Cancer
Interventions: DRUG: Surufatinib|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 177Lu-anti-PD-L1 sdAb in Metastatic Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: PDL1 Gene Mutation|Non Small Cell Lung Cancer
Interventions: DRUG: 177Lu-RAD204
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heartfulness Meditation to Improve Resilience Among Health Care Students: A 90 Day Program
Status: UNKNOWN
Conditions: Mental Health Wellness 1|Stress, Psychological|Depression|Anxiety
Interventions: BEHAVIORAL: Heartfulness Meditation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Performance and Hearing-related Outcomes in Adults Implanted With the CI622D Dexamethasone-eluting Cochlear Implant Compared to Those Implanted With a Standard Cochlear Implant (CI622)
Status: RECRUITING
Conditions: Hearing Loss, Bilateral Sensorineural|Hearing Loss, Sensorineural|Hearing Loss, Bilateral|Hearing Loss, Cochlear
Interventions: DEVICE: CI622D|DEVICE: CI622
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Endobronchial Ultrasound Guided Transbronchial Needle Aspiration Performed Under General Anesthesia Versus Moderate Sedation
Status: COMPLETED
Conditions: Mediastinal Lymphadenopathies|Mediastinal Masses|Hilar Lymphadenopathies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Irreversible Electroporation(IRE) For Unresectable Gallbladder Neoplasms
Status: COMPLETED
Conditions: Gallbladder Neoplasms
Interventions: PROCEDURE: Irreversible electroporation (IRE)|DEVICE: NanoKnife
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Branched-chain Amino Acids in the Development of Insulin Resistance
Status: COMPLETED
Conditions: Diabetes
Interventions: DIETARY_SUPPLEMENT: Branched-chain amino acids reduced intake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Pregabalin in Idiopathic Small Fiber Neuropathy
Status: TERMINATED
Conditions: Small-Fiber Neuropathy
Interventions: DRUG: Pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Home Physiotherapy in Frailty in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease|Physical Therapy Modalities|Frailty
Interventions: OTHER: Home Physiotherapy Group|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Functioning and Health Related Quality of Life in Retinoblastoma Survivors
Status: ENROLLING_BY_INVITATION
Conditions: Retinoblastoma|Neurocognitive Dysfunction|Health-Related Behavior
Interventions: DIAGNOSTIC_TEST: Neuropsychological assesment|DIAGNOSTIC_TEST: Psychosocial functioning and quality of life (questionnaires)|DIAGNOSTIC_TEST: Parental psychosocial functioning (questionnaires)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Acupuncture on Vasomotor Rhinitis
Status: COMPLETED
Conditions: Vasomotor Rhinitis|Acupuncture
Interventions: DEVICE: Acupuncture|DEVICE: Sham-laser acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Trial of Aerobic Exercise in Patients Undergoing Outpatient Hemodialysis
Status: COMPLETED
Conditions: Kidney Failure, Chronic
Interventions: BEHAVIORAL: ergometer exercise during hemodialysis|BEHAVIORAL: pedometer activity outside of hemodialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Nivolumab, Cabiralizumab, and Stereotactic Body Radiotherapy (SBRT) for Locally Advanced Unresectable Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: Nivolumab + Cabiralizumab|RADIATION: Stereotactic Body Radiotherapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Brain Stimulation as a Treatment for Dysarthria Post-stroke
Status: COMPLETED
Conditions: Dysarthria|Stroke
Interventions: DEVICE: Real tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of Intralesional Recombinant Tumor Necrosis Factor in Patients With AIDS-Related Cutaneous Kaposi's Sarcoma
Status: COMPLETED
Conditions: Sarcoma, Kaposi|HIV Infections
Interventions: DRUG: Tumor Necrosis Factor
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of 18F-FEC for Positron Emission Tomography-Computed Tomography (PET-CT) Imaging of GBM
Status: WITHDRAWN
Conditions: Astrocytoma, Grade IV|Giant Cell Glioblastoma|Glioblastoma Multiforme
Interventions: RADIATION: External-beam radiation therapy|DRUG: Temozolomide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: EUS-FNA With 22G Procore Needles vs 22G Conventional Needles
Status: COMPLETED
Conditions: Self Efficacy
Interventions: PROCEDURE: EUS-guided FNA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy and Safety of the Topical Product in Patients With Mild to Severe Scalp Psoriasis
Status: COMPLETED
Conditions: Scalp Psoriasis
Interventions: DRUG: DSXS|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on SANGUINATE™ for the Reduction of Delayed Graft Function in Kidney Transplant Patients
Status: WITHDRAWN
Conditions: Delayed Function of Renal Transplant
Interventions: DRUG: SANGUINATE|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Ipilimumab 3 mg/kg Versus Ipilimumab 10 mg/kg in Subjects With Metastatic Castration Resistant Prostate Cancer Who Are Chemotherapy Naive
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Calcium Dobesilate to Treat Chinese Patients With Mild to Moderate Non-proliferative Diabetic Retinopathy
Status: UNKNOWN
Conditions: Diabetic Retinopathy
Interventions: DRUG: Calcium Dobesilate|OTHER: conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate a Multiple Model Probabilistic Predictive Controller (MMPPC) for Closed Loop Insulin Delivery
Status: WITHDRAWN
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: Multiple Model Predictive Controller
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulsed Magnetic Stimulation - Managing Spasticity in Spinal Cord Injury
Status: UNKNOWN
Conditions: Spinal Cord Injuries
Interventions: PROCEDURE: Sub-threshold intermittent pulsed magnetic stimulation|PROCEDURE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gefitinib With or Without Carboplatin and Paclitaxel in Treating Older Patients With Unresectable or Metastatic Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: gefitinib|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Rosuvastatin on Endothelial Function in Patients With Diabetes and Glaucoma
Status: WITHDRAWN
Conditions: Glaucoma|Diabetes
Interventions: DRUG: Rosuvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Mirikizumab (LY3074828) in Participants With Ulcerative Colitis
Status: WITHDRAWN
Conditions: Ulcerative Colitis
Interventions: DRUG: Mirikizumab IV|DRUG: Mirikizumab SC|DRUG: Vedolizumab IV|DRUG: Placebo IV|DRUG: Placebo SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotics on Gut-Liver Axis of Alcoholic Liver Disease
Status: COMPLETED
Conditions: Alcoholic Liver Disease
Interventions: DRUG: hepatitis, alcohol, probiotics|DRUG: alcohol, hepatitis, Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mapping the Impact of Gut Microbiota on Brain and Behavior Through the Lens of GABA
Status: RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The PRICE Trial: Pain Reduction for Intrauterine Contraception Experiment
Status: RECRUITING
Conditions: Contraception
Interventions: DRUG: 1% Lidocaine Paracervical Block|DRUG: Normal Saline Paracervical Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Open-Label "Compassionate" Use Study of Spiramycin for the Treatment of Diarrhea Due to Chronic Cryptosporidiosis in Immunocompromised Patients
Status: COMPLETED
Conditions: Cryptosporidiosis|HIV Infections
Interventions: DRUG: Spiramycin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of Etelcalcetide in Hemodialysis Patients With Secondary Hyperparathyroidism
Status: COMPLETED
Conditions: Hyperparathyroidism, Secondary
Interventions: DRUG: Placebo|DRUG: Etelcalcetide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Docetaxel +/- Nintedanib in Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Docetaxel|DRUG: Nintedanib|DRUG: Docetaxel: increase of the dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determining the Right Acupuncture for Good Recovery Over Neuropsychiatric Trauma
Status: RECRUITING
Conditions: PTSD|Post Traumatic Stress Disorder|Acupuncture
Interventions: OTHER: Dragons acupuncture|OTHER: Dragons acupressure|OTHER: Dragons placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Oxytocin vs. Placebo for the Treatment of Hyperphagia in Prader-Willi Syndrome
Status: UNKNOWN
Conditions: Prader-Willi Syndrome|Hyperphagia
Interventions: DRUG: Intranasal Oxytocin (IN-OXT)|DRUG: Matched Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.
Status: RECRUITING
Conditions: Carcinoma, Pancreatic Ductal|Colorectal Neoplasms|Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: PF-07934040|COMBINATION_PRODUCT: Gemcitabine|COMBINATION_PRODUCT: Nab-paclitaxel|COMBINATION_PRODUCT: Cetuximab|COMBINATION_PRODUCT: Fluorouracil|COMBINATION_PRODUCT: Oxaliplatin|COMBINATION_PRODUCT: Leucovorin|COMBINATION_PRODUCT: Bevacizumab|COMBINATION_PRODUCT: Pembrolizumab|COMBINATION_PRODUCT: pemetrexed|COMBINATION_PRODUCT: Cisplatin|COMBINATION_PRODUCT: Paclitaxel|COMBINATION_PRODUCT: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Myocardial Ischemia by Preconditioning in Elective Operation for Abdominal Aortic Aneurysm
Status: UNKNOWN
Conditions: Aortic Aneurysm
Interventions: PROCEDURE: preconditioning|PROCEDURE: Normal surgery, with sham intervention without inflating arm cuff
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Total Intravenous Anesthesia in Sinus Surgery
Status: COMPLETED
Conditions: Advanced Chronic Rhinosinusitis
Interventions: DRUG: Propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Autologous Stem Cells in Achilles Tendinopathy
Status: UNKNOWN
Conditions: Achilles Tendinitis, Right Leg|Achilles Tendinitis|Achilles Degeneration|Achilles Tendon Thickening|Tendinopathy|Achilles Tendinitis, Left Leg
Interventions: BIOLOGICAL: Autologous Mesenchymal Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperpolarized 13C Pyruvate MRI Scan in Predicting Tumor Aggressiveness in Patients With Renal Tumors
Status: RECRUITING
Conditions: Benign Kidney Neoplasm|Kidney Neoplasm|Renal Cell Cancer
Interventions: DRUG: Hyperpolarized Carbon C 13 Pyruvate|PROCEDURE: Magnetic Resonance Imaging|DRUG: Hyperpolarized 13C,15N2-urea
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: An Investigational Study to Evaluate Experimental Medication BMS-986165 Compared to Placebo in Participants With Plaque Psoriasis (POETYK-PSO-3) in Mainland China, Taiwan, and South Korea
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: BMS-986165|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Reduced-port Laparoscopic Surgery for Patients Of Colon and Upper Rectal Cancer
Status: RECRUITING
Conditions: Colorectal Neoplasm
Interventions: PROCEDURE: Reduced-port laparoscopic surgery|PROCEDURE: conventional laparoscopic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Marketing Surveillance of Micombi Tablets Survey on the Long-term Use
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan 80mg|DRUG: Telmisartan 40mg|DRUG: Hydrochlorothiazide 12.5mg
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Environmental or Nasal Cannula Oxygen for Preterm Infants Receiving Oxygen Therapy: a Randomized Cross-over Pilot Study
Status: COMPLETED
Conditions: Infant, Newborn, Diseases|Hypoxia
Interventions: PROCEDURE: Oxygen Environment|PROCEDURE: Nasal Cannula Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Toffee Nasal and Toffee Nasal Pillows Mask in Home, USA, 2022
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: F&P Toffee Nasal and Toffee Nasal Pillows Masks
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Same Day Discharge (SDD) After Implantable Cardioverter Defibrillator (ICD) Implant
Status: COMPLETED
Conditions: Heart Failure|Coronary Artery Disease
Interventions: OTHER: Same Day Discharge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bacillus Calmette-Guérin (BCG) and Gemcitabine in People With High-Grade Non-Muscle Invasive Bladder Cancer That Came Back After BCG Treatment
Status: RECRUITING
Conditions: Non-Muscle Invasive Bladder Cancer (NMIBC)
Interventions: DRUG: Bacillus Calmette-Guérin (BCG)|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase IIIb Study of APD421 in Combination as PONV Prophylaxis
Status: COMPLETED
Conditions: PONV
Interventions: DRUG: APD421|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PD and PK Profiles of Switching Between Cangrelor and Ticagrelor Following Ticagrelor Pre-treatment
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Cangrelor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Wound Architecture and Functional Outcome After Cataract Surgery With Manual vs.Femtosecond Laser Assisted Procedures
Status: COMPLETED
Conditions: Cataract
Interventions: PROCEDURE: Femtosecond cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A 12-week Intervention With Motivational Interviewing and Physical Activity Monitoring, to Enhance the Daily Amount of Physical Activity in Community Dwelling Older Adults - a Randomized Controlled Trial
Status: COMPLETED
Conditions: Aging|Physical Activity|Older Adults
Interventions: BEHAVIORAL: Motivational interviews|BEHAVIORAL: Base intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Inspiratory Muscle Training on Daily Physical Activity (INAF)
Status: UNKNOWN
Conditions: Inspiratory Muscle Training
Interventions: DEVICE: ORYGEN DUAL Sham Valve|DEVICE: ORYGEN DUAL Valve
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Accelerated, Theta-burst Stimulation for the Treatment of Post-concussion Syndrome
Status: RECRUITING
Conditions: Post Concussion Syndrome
Interventions: DEVICE: Intermittent Theta-Burst Stimulation|DEVICE: Sham Intermittent Theta-Burst Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Monocentric Phase 1 Study With Escalation of Doses of Tocilizumab in Combination With Chemotherapy (Idarubicin and Cytarabine) in Patients With Acute Myeloblastic Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)
Interventions: DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Single Rising Oral Doses of BI 224436 ZW in Healthy Male Volunteers.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 224436|DRUG: Placebo to BI 224436
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: PTCy and ATG for MSD and MUD Transplants
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Myelodysplastic Syndromes|Hodgkin Lymphoma|Non-hodgkin Lymphoma
Interventions: DRUG: ATG 5.0|DRUG: Cyclophosphamide injection|DRUG: ATG 2.5±1.5
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Minimally Invasive Ridge Splitting Versus the Conventional Open Flap Technique
Status: RECRUITING
Conditions: Alveolar Bone Loss
Interventions: PROCEDURE: Minimally invasive implantation|PROCEDURE: Open flap procedure for ridge expansion.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Fish Oil Supplement to Maintain Body Weight in Patients With Disease-Related Weight Loss
Status: COMPLETED
Conditions: Cancer|Cancer Cachexia|Chronic Obstructive Pulmonary Disease|Chronic Heart Failure|Rheumatoid Arthritis
Interventions: DRUG: Fish oil supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept Study of MTC896 Gel to Reduce Sebum Production on the Forehead of Healthy Male Volunteers
Status: COMPLETED
Conditions: Oily Skin|Seborrhea
Interventions: DRUG: MTC896 Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: Vitamin D|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study of Excimer Laser and Drug Coated Balloon Versus Excimer Laser and Plain Balloon Versus Plain Balloon and Drug Coated Balloon to Treat Femoropopliteal In-stent Restenosis
Status: UNKNOWN
Conditions: Atherosclerosis of Artery|In-stent Arterial Restenosis
Interventions: DEVICE: Excimer laser and drug coated balloon|DEVICE: Excimer laser and plain balloon|DEVICE: plain balloon and drug coated balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Administration of Fostamatinib on Blood Concentrations of an Oral Contraceptive in Healthy Female Subjects
Status: COMPLETED
Conditions: Scientific Terminology Rheumatoid Arthritis, Healthy Female Volunteers, Pharmacokinetics, Oral Contraceptive, Drug-drug Interaction|Laymen Terminology Level of Oral Contraceptive in Blood, Oral Contraceptive, Rheumatoid Arthritis, Drug -Drug Interaction
Interventions: DRUG: fostamatinib|DRUG: Microgynon® 30 (Oral contraceptive)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of a Cosmetic Shampoo RV3438G in Reccurent Squamous States
Status: COMPLETED
Conditions: Dermatitis, Seborrheic
Interventions: OTHER: Phase 1: short intensive treatment phase|OTHER: Phase 2 : Tested product RV3438G associated with gentle balancing shampoo|OTHER: Phase 2 : Tested product RV3438G associated with neutral shampoo|OTHER: Phase 2 : neutral shampoo
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Treatment of Progressive Early Onset Spinal Deformities: A Multi-Center Outcome Study
Status: COMPLETED
Conditions: Early Onset Scoliosis|Congenital Spinal Deformities|Infantile Idiopathic Scoliosis|Neuromuscular Spinal Deformity|Syndromic Spinal Deformity|Thoracic Insufficiency Syndrome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Enamel Matrix Derivatives & Periodontal Therapy in Diabetic Patients
Status: UNKNOWN
Conditions: Periodontal Diseases
Interventions: PROCEDURE: Root Instrumentation|DEVICE: Enamel Matrix Derivative application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Neointimal Coverage Between Zotarolimus Eluting Stent and Everolimus Eluting Stent
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Zotarolimus eluting stent (Endeavor resoulte - ZES resolute)|DEVICE: Everolimus eluting stent (Xience - EES)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Of Doxycycline And Common Salt For Treatment Of Umbilical Granuloma: A Randomised Control Trial
Status: COMPLETED
Conditions: Umbilical Granuloma
Interventions: DRUG: Doxycyclin|OTHER: COMMON SALT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Pharmacokinetics of 2% TD1414 Cream in Adults With Secondarily Infected Traumatic Lesions (SITL) or Impetigo
Status: COMPLETED
Conditions: Secondarily Infected Traumatic Lesions (SITL)|Impetigo
Interventions: DRUG: 2% TD1414 Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of RIC on BP and Inflammatory Response in Women With Pre-eclampsia
Status: COMPLETED
Conditions: Pre-Eclampsia; Mild|Gestational Hypertension
Interventions: DEVICE: Remote Ischaemic Conditioning (RIC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Ranging Effect of Preoperative Diphenhydramine on Postoperative Quality of Recovery After Ambulatory Surgery
Status: COMPLETED
Conditions: Surgery|Pain
Interventions: DRUG: .9 normal saline|DRUG: 25 mg diphenhydramine IV|DRUG: 50 mg diphenhydramine IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vaccine Therapy Plus Immune Adjuvants in Treating Patients With Advanced Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: QS21|BIOLOGICAL: gp100 antigen|BIOLOGICAL: incomplete Freund's adjuvant|BIOLOGICAL: sargramostim|BIOLOGICAL: tyrosinase peptide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Vitamin D and Hereditary Haemorrhagic Telangiectasia
Status: UNKNOWN
Conditions: Hereditary Haemorrhagic Telangiectasia
Interventions: DRUG: Vit D|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Key Information Can Influence Clinician Ordering of Brain CTs
Status: COMPLETED
Conditions: Clinical Decision-Making
Interventions: OTHER: Simulation-based clinical decision on brain CT ordering
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Daratumumab, Bortezomib, and Dexamethasone Followed by Daratumumab, Ixazomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: DRUG: Bortezomib|BIOLOGICAL: Daratumumab|DRUG: Dexamethasone|DRUG: Ixazomib|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Neuroimage Study of the Neuromuscular Disorders.
Status: RECRUITING
Conditions: Neuromuscular Diseases
Interventions: DIAGNOSTIC_TEST: Neuromuscular ultrasound|DIAGNOSTIC_TEST: Muscle MRI|DIAGNOSTIC_TEST: Nerve conduction studies and autonomic function tests|DIAGNOSTIC_TEST: Quantitative sensory test|DIAGNOSTIC_TEST: Skin biopsy|DIAGNOSTIC_TEST: Muscle and nerve biopsy|DIAGNOSTIC_TEST: Genomics, transcriptome, and proteomics|DIAGNOSTIC_TEST: Laboratory of blood chemical substances, metals and endocrine profiles|DIAGNOSTIC_TEST: Contact heat evoked potentials|DIAGNOSTIC_TEST: Nerve excitability study|DIAGNOSTIC_TEST: Transcranial magnetic stimulation (TMS)|DIAGNOSTIC_TEST: fMRI acquisition and image analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety and Tolerability of AZD7442 in Chinese Adults
Status: COMPLETED
Conditions: Coronavirus Disease 2019 (COVID-19)
Interventions: DRUG: 600 mg AZD7442 IV|DRUG: 600mg placebo IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Deep Brain Stimulation for Major Depressive Disorder
Status: TERMINATED
Conditions: Depressive Disorder, Major|Unipolar Depression
Interventions: DEVICE: Deep Brain Stimulation, Libra Deep Brain Stimulation System|DEVICE: Deep Brain Stimulation, Libra Deep Brain Stimulation System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-articular Injection in the Knee of Adipose Derived Stromal Cells and Platelet Rich Plasma for Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: BIOLOGICAL: Intra-articular injection of SVF plus PRP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of the Efficacy and Safety of Muscarinic M3 Receptors Antagonists in the Treatment of Neurogenic Detrusor Overactivity
Status: COMPLETED
Conditions: Spinal Cord Injury|Neurogenic Detrusor Overactivity
Interventions: DRUG: Oxybutynin Cl|DRUG: Trospium Cl|DRUG: Darifenacin Hydrogen Bromide (HBr)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The LIPMAT Study: Liposomal Prednisolone to Improve Hemodialysis Fistula Maturation
Status: TERMINATED
Conditions: Renal Dialysis|Hemodynamics|Vascular Remodeling|Neointima
Interventions: DRUG: PEG-liposomal prednisolone sodium phosphate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Reablement in Home Dwelling Older Adults. A Randomized Controlled Trial
Status: COMPLETED
Conditions: Physical Disability
Interventions: BEHAVIORAL: Reablement|BEHAVIORAL: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CF101 Therapy Compared to Methotrexate Therapy for Active Rheumatoid Arthritis
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: CF101 1 mg|DRUG: CF101 2 mg|DRUG: Placebo|DRUG: MTX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Erector Spinae Plane Block With PECS II Block in Patients Undergoing Breast Cancer Surgery
Status: WITHDRAWN
Conditions: Breast Cancer|Anesthesia, Local
Interventions: PROCEDURE: ESP BLOCK|PROCEDURE: PECS BLOCK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Study of Teduglutide in Pediatric Subjects With Short Bowel Syndrome Who Completed the TED-C13-003 Study
Status: COMPLETED
Conditions: Short Bowel Syndrome
Interventions: DRUG: Teduglutide|OTHER: SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study to Compare Diclofenac Potassium Coated Tablet Versus Cataflam® 50 Coated Tablet
Status: COMPLETED
Conditions: Non-steroidal Anti-inflammatory (NSAID)|Analgesic|Antipyretic
Interventions: DRUG: Diclofenac Potassium coated tablet (50 mg Diclofenac Potassium)|DRUG: Cataflam® 50 coated tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pancrelipase in People With Pancreatic Ductal Adenocarcinoma (PDAC)
Status: RECRUITING
Conditions: Metastatic Pancreatic Ductal Adenocarcinoma|Metastatic Pancreatic Cancer|Metastatic Pancreatic Adenocarcinoma|Metastatic Pancreatic Carcinoma|Pancreatic Carcinoma|Pancreatic Carcinoma Metastatic|Pancreatic Carcinoma Non-resectable|Pancreatic Cancer|Pancreatic Cancer Non-resectable|Pancreatic Cancer Stage IV|Pancreatic Cancer Metastatic|PDAC|PDAC - Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: Pertzye
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Gastrointestinal Safety of PLA-695 Compared to Placebo and Naproxen
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PLA-695|DRUG: Naproxen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Postoperative NSCLC Treated With Integrated Medicine Base on Circulating Tumor Cell Detection
Status: UNKNOWN
Conditions: NSCLC
Interventions: DRUG: Jinfukang Koufuye|DRUG: Docetaxel|DRUG: Pemetrexed|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Intervention to Reduce the Social Isolation and Loneliness of Elderly Residents at Home
Status: UNKNOWN
Conditions: Social Isolation, Loneliness (Descriptors Included in the MeSH)
Interventions: BEHAVIORAL: non-pharmacological multicomponent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Add-on Therapy With Edupression.Com® on Therapy Resistant Depressive Patients Treated With Nasal Esketamine Spray
Status: UNKNOWN
Conditions: Major Depressive Disorder|Therapy Resistant Depression
Interventions: DEVICE: edupression.com®|DRUG: Esketamine nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Biomechanical Effects of Flaccid Paralysis Induced by Botulinum Toxin a After Damage Control Laparotomy
Status: COMPLETED
Conditions: Wound; Abdomen, Abdominal Wall
Interventions: DRUG: Botulinum Toxin Type A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nutriose Supplementation on Satiety, Weight Loss and Adiposity in Overweight Subjects
Status: COMPLETED
Conditions: Overweight
Interventions: DIETARY_SUPPLEMENT: NUTRIOSE FB06|DIETARY_SUPPLEMENT: GLUCIIDEX 21
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Validity and Reliability of the Turkish Version of the Pectus Carinatum Body Image Quality of Life Questionnaire for Patients With Pectus Carinatum
Status: COMPLETED
Conditions: Pectus Carinatum|Quality of Life|Body Image|Brace
Interventions: OTHER: Brace Treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study With Deferiprone and/or Desferrioxamine in Iron Overloaded Patients
Status: COMPLETED
Conditions: Hemochromatosis
Interventions: DRUG: Deferiprone (L1)|DRUG: Desferrioxamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The HuggyPuppy Intervention for War-related Distress
Status: COMPLETED
Conditions: Stress Related Disorder
Interventions: BEHAVIORAL: The HuggyPuppy Intervention: Original doll|BEHAVIORAL: The HuggyPuppy Intervention: Monkey doll|BEHAVIORAL: The HuggyPuppy Intervention: Dog without velcro doll|BEHAVIORAL: The HuggyPuppy Intervention: Bear doll|BEHAVIORAL: The HuggyPuppy Intervention: Rabbit doll
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Tenofovir Disoproxil Fumarate in Adolescents With Chronic Hepatitis B Infection
Status: COMPLETED
Conditions: Hepatitis B Virus (HBV)
Interventions: DRUG: Tenofovir disoproxil fumarate (TDF)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Real-time Amino Acid Profiling
Status: COMPLETED
Conditions: Protein Digestion Kinetics
Interventions: DIETARY_SUPPLEMENT: Casein|DIETARY_SUPPLEMENT: Dairy protein blend 1|DIETARY_SUPPLEMENT: Whey protein|DIETARY_SUPPLEMENT: Dairy protein blend 2|DIETARY_SUPPLEMENT: Dairy protein blend 3|DIETARY_SUPPLEMENT: Dairy protein blend 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Determine the Relationship Between Baseline Reversibility and the Efficacy of Indacaterol
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Indacaterol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Dose IMVAMUNE® in Vaccinia-Naive Individuals
Status: COMPLETED
Conditions: Variola Major (Smallpox)
Interventions: BIOLOGICAL: IMVAMUNE® High Dose|DRUG: Placebo|BIOLOGICAL: IMVAMUNE® Standard Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Multi-Center Clinical Evaluation of Two Daily Disposable Contact Lenses (Study 2)
Status: COMPLETED
Conditions: Refractive Error
Interventions: DEVICE: Nelfilcon A contact lens|DEVICE: UltraFilcon B contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Correlating QLV Interval to Left Ventricular (LV) Lead Position in Patients Receiving Cardiac Resynchronization Therapy.
Status: COMPLETED
Conditions: Heart Failure|Cardiomyopathy|Cardiac Arrhythmia
Interventions: PROCEDURE: QLV interval measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hormones and Decision Making
Status: COMPLETED
Conditions: Dyssocial Behavior
Interventions: DRUG: testosterone propionate|DRUG: 0.5% cholorbutanol, saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Inavolisib|DRUG: Fulvestrant|DRUG: Alpelisib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Learning Curves of Intubation for Simulated Difficult Airway Scenarios by Manikin: Comparison of Combined Pentax Airwayscope-fiberoptic Bronchoscope and Fiberoptic Bronchoscope Alone
Status: UNKNOWN
Conditions: Difficult Airway
Interventions: DEVICE: manikin|DEVICE: fiberoptic bronchoscope|DEVICE: pentax-airwayscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics and Metabolism of Hydrocodone Bitartrate Extended-Release (HC-ER) in Subjects With Renal Impairment
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: 20 mg HC-ER|DRUG: 20 mg HC-ER|DRUG: 20 mg HC-ER
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER