pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Investigate Sitravatinib as Monotherapy and in Combination With Tislelizumab in Participants With Unresectable Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) or Gastric/Gastroesophageal Junction Cancer (GC/GEJC)
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular|Gastric/Gastroesophageal Junction Cancer
Interventions: DRUG: Sitravatinib|DRUG: Sitravatinib plus Tislelizumab|DRUG: Sitravatinib|DRUG: Sitravatinib and tislelizumab|DRUG: Sitravatinib and tislelizumab|DRUG: Sitravatinib and tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sugammadex in High-Risk Ambulatory Surgeries
Status: WITHDRAWN
Conditions: Ambulatory Difficulty
Interventions: DRUG: Sugammadex|DRUG: Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Efficiency of IV Dexamethasone, Administered After a Lower Limb Blockade, on the Post Operative Pain in Children
Status: UNKNOWN
Conditions: IV Drug Usage
Interventions: DRUG: Dexamethasone|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Methylene Blue in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease
Status: UNKNOWN
Conditions: Mild Cognitive Impairment|MCI|Aging|Alzheimer's Disease|AD
Interventions: DRUG: Methylene Blue|DRUG: FD&C Blue # 2|DRUG: Phenazopyridine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of an Otic Formulation in Treating Peri-Operative Tube Otorrhea
Status: COMPLETED
Conditions: Acute Otitis Media
Interventions: DRUG: Moxidex otic solution|DRUG: Moxifloxacin otic solution|DEVICE: Tympanostomy tubes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy and Safety of Upadacitinib in Adults With Axial Spondyloarthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Spondyloarthritis
Interventions: DRUG: Upadacitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficacy of Cefotaxime, Ceftriaxone, and Ciprofloxacin for the Treatment of SBP in Patients With LC
Status: COMPLETED
Conditions: SBP|Liver Cirrhosis
Interventions: DRUG: Cefotaxime|DRUG: Ceftriaxone|DRUG: Ciprofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VX-950-TiDP24-C219: A Roll Over Trial for Patients in the Control Group of the C216 Study Who Received Telaprevir Placebo
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Telaprevir|DRUG: pegylated interferon (Peg-IFN) alfa-2a|DRUG: ribavirin (RBV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Regional Brain Kinetics of the Positron Emission Tomography Ligand 11C-MK-3168 and the Blocking of the Retention of the Ligand in the Human Brain by JNJ-42165279
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-42165279|DRUG: 11C-MK-3168
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Entinostat in Combination With Nivolumab for Patients With Previously Treated Unresectable or Metastatic Cholangiocarcinoma and Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Metastatic Cholangiocarcinoma|Cholangiocarcinoma|Pancreatic Cancer|Metastatic Pancreatic Cancer|Unresectable Pancreatic Cancer|Unresectable Cholangiocarcinoma
Interventions: DRUG: Entinostat|DRUG: Nivolumab|DRUG: Entinostat|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Breast Duct: Pilot Study of Genomic Sequencing of Exfoliated Ductal Cells Obtained Through Endoscopy and Lavage
Status: COMPLETED
Conditions: Breast Cancer|Preneoplastic Conditions|Ductal Carcinoma in Situ
Interventions: DEVICE: Nipple aspirator|DEVICE: Ductal lavage microcatheter|DEVICE: Blood draw
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigation of the Effect of Degarelix in Terms of Prostate Volume Reduction in Prostate Cancer Patients
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Degarelix|DRUG: Goserelin|DRUG: Bicalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accelerated Partial Breast Irradiation Versus Standard or Hypofractionated Whole-Breast Irradiation, in Early Breast Cancer, After Breast-conserving Surgery
Status: RECRUITING
Conditions: Malignant Neoplasm of Breast
Interventions: RADIATION: Active Comparator: Standard|RADIATION: Experimental 1: Hypofractionated radiotherapy|RADIATION: Experimental 2: Accelerated Partial Breast Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of First-Line Ambrisentan and Tadalafil Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH)
Status: COMPLETED
Conditions: Hypertension, Pulmonary
Interventions: DRUG: ambrisentan|DRUG: tadalafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Acupuncture as an Adjunct to Methadone Treatment Services for Heroin Addicts
Status: UNKNOWN
Conditions: Opiate Withdrawal Syndrome
Interventions: PROCEDURE: Ear acupressure alone|PROCEDURE: Electroacupuncture plus ear acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Personalized Prognostic Counseling on IVF Patient's Experience and Treatment Utilization
Status: RECRUITING
Conditions: Infertility
Interventions: OTHER: Counseling Supported by Univfy® Report|OTHER: Standard Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cohort Multiple Randomized Controlled Trials Open-label of Immune Modulatory Drugs and Other Treatments in COVID-19 Patients - Sarilumab Trial - CORIMUNO-19 - SARI
Status: UNKNOWN
Conditions: Corona Virus Infection
Interventions: DRUG: Sarilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Shock Wave Therapy Versus High Power LASER Therapy for the Treatment of Females With Calcaneal Spur
Status: NOT_YET_RECRUITING
Conditions: Calcaneal Spur
Interventions: DRUG: Platelet rich plasma|OTHER: High power LASER|OTHER: Shockwave therapy|OTHER: Ice application|OTHER: Sham LASER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study of the HSP90 Inhibitor, STA-9090 in Subjects With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Blast-phase Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Blast-phase Chronic Myelogenous Leukemia|AML|ALL|CML
Interventions: DRUG: STA-9090 (ganetespib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VERITAS: An Evaluation of the Veniti Vidi Retrievable Inferior Vena Cava Filter System in Patients at Risk for Pulmonary Embolism
Status: WITHDRAWN
Conditions: Deep Vein Thrombosis|Pulmonary Embolus
Interventions: DEVICE: Veniti Inferior Vena Cava Filter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Paravertebral Block With Dexamethasone on Intraoperative and Postoperative Analgesia in Children Undergoing Surgery for Coarctation of Aorta
Status: COMPLETED
Conditions: Coarctation of Aorta
Interventions: DRUG: Dexamethasone|DEVICE: ultrasound|PROCEDURE: paravertebral block|DRUG: Bupivacaine|OTHER: isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety of Topical Tranexamic Acid in Total Joint Arthroplasty in High Risk Patients
Status: WITHDRAWN
Conditions: Pulmonary Embolism|Deep Vein Thrombosis|Stroke|Myocardial Infarction
Interventions: DRUG: Tranexamic Acid|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 1L-PEG-Asc Solution for Bowel Preparation in an "Open Access" Colonoscopy Booking System: Evaluation of Adverse Events
Status: COMPLETED
Conditions: Bowel Preparation
Interventions: OTHER: use of a very low-volume 1L-PEG plus ascorbate (plenvu) or low-volume 2L-PEG plus ascorbate (moviprep) for bowel preparation in open access colonoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Adjuvant Endocrine Therapy With Aromatase Inhibitors on the Postoperative Lipid Levels in Postmenopausal Breast Cancer Patients
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Exemestane|DRUG: Letrozole|DRUG: Anastrozole
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Homologous PRP vs Placebo in Knee Osteoarthritis in Over 65 Years Old Patients
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Homologous PRP injections|PROCEDURE: Placebo injection (saline solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Autologous Serum and Umbilical Cord Serum Eyedrops for Dry Eye Syndrome
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: Umbilical cord serum eyedrops|DRUG: Autologous serum eyedrops
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Combination of Haloperidol and Magnesium for Delirium Prevention in Critically Ill Elderly
Status: COMPLETED
Conditions: Delirium in Old Age
Interventions: DRUG: Haloperidol Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of B7-H3 CAR-T in Treating Patients With Recurrent and Refractory Glioblastoma
Status: RECRUITING
Conditions: Recurrent Glioblastoma|Refractory Glioblastoma
Interventions: DRUG: B7-H3 CAR-T|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Progressive Intensity Exercise Training on Glycemic Control in Older Adults
Status: COMPLETED
Conditions: PreDiabetes|Aging
Interventions: BEHAVIORAL: Moderate Intensity Exercise Training (MOD)|BEHAVIORAL: Vigorous Intensity Exercise Training (VIG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Aortic Valve replAcement in eLective Patients From aOrtic Valve multiceNter Registry
Status: COMPLETED
Conditions: Aortic Valve Stenosis
Interventions: PROCEDURE: Surgical Aortic Valve Replacement|PROCEDURE: Transcutenous Aortic Valve Implantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Prolonged Electrical Stimulation on Neural Plasticity in Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: BEHAVIORAL: Somatosensory Stimulation and Massed Practice Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Aerosolized Albuterol Use in Severe BPD
Status: COMPLETED
Conditions: Severe Bronchopulmonary Dysplasia
Interventions: DRUG: Albuterol Sulfate|DRUG: Sterile Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TET2 Mutations in Myelodysplastic Syndromes and Acute Myeloid Leukemia With Azacitidine + Ascorbic Acid
Status: COMPLETED
Conditions: Myelodysplastic Syndromes|Myeloproliferative Neoplasm|Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|DRUG: Ascorbic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Motivational Interview and Orthodontic Patients
Status: COMPLETED
Conditions: Motivational Interviewing|Oral Hygiene|Orthodontic Appliance Complication
Interventions: BEHAVIORAL: Motivational interviewing|BEHAVIORAL: Oral Hygiene Instructions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Trial of Bed Versus Stirrups Delivery in Nulliparous Women for Prevention of Perineal Lacerations
Status: COMPLETED
Conditions: Perineal Lacerations
Interventions: OTHER: Stirrups delivery vs bed delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Testosteron Replacement Treatment on the Fibroblast Growth Factor-23, Asymmetric Dimethylarginine and Vitamin D Levels in the Congenital Hypogonadotropic Hypogonadism
Status: COMPLETED
Conditions: Hypogonadism
Interventions: DRUG: Testosterone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Transcranial Direct Current Stimulation for Motor Recovery From Severe Post-stroke Hemiparesis
Status: TERMINATED
Conditions: Stroke|Hemiparesis
Interventions: DEVICE: transcranial direct current stimulation|BEHAVIORAL: intensive upper extremity motor training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Control After VATS Anatomical Pulmonary Resections
Status: RECRUITING
Conditions: Lung Cancer|Pain, Postoperative|Thoracic Neoplasms
Interventions: PROCEDURE: Epidural|PROCEDURE: ESP block|PROCEDURE: Cryoanalgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: (KIWI) Speeding up a Slow Protein for Muscle Mass With Hay Kiwifruit
Status: COMPLETED
Conditions: Metabolism|Protein
Interventions: DIETARY_SUPPLEMENT: Green Hayward Kiwifruit first, then Gold Kiwifruit|DIETARY_SUPPLEMENT: Gold Kiwifruit First, then Green Hayward Kiwifruit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of DARE-HRT1 Over 12 Weeks in Healthy PostMenopausal Women
Status: COMPLETED
Conditions: Vulvovaginal Atrophy|Vasomotor Symptoms
Interventions: DEVICE: IVR Dose 1|DEVICE: IVR Dose 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of T1225 1.5% Versus Tobramycin 0.3 % in the Treatment of Purulent Bacterial Conjunctivitis
Status: COMPLETED
Conditions: Conjunctivitis, Bacterial
Interventions: DRUG: Azithromycin (T1225)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Patellofemoral Osteoarthritis With Engineered Cartilage.
Status: RECRUITING
Conditions: Patellofemoral Osteoarthritis
Interventions: BIOLOGICAL: N-TEC|BIOLOGICAL: Platelet rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Hip Extension and Nordic Hamstring Exercise Programmes on Isokinetic Hamstring Strength
Status: COMPLETED
Conditions: Hamstring Injury
Interventions: OTHER: Nordic hamstring exercise|OTHER: Hip extension exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Dato-DXd in Chinese Patients With Advanced Non-Small Cell Lung Cancer, Triple-negative Breast Cancer and Other Solid Tumors (TROPION-PanTumor02)
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung|Triple Negative Breast Cancer
Interventions: DRUG: Datopotamab Deruxtecan (Dato-DXd)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tislelizumab as Monotherapy in Relapsed or Refractory Classical Hodgkin Lymphoma
Status: COMPLETED
Conditions: Classical Hodgkin Lymphoma
Interventions: DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate a New Tablet Formulation of Lu AG06466 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lu AG06466 Capsule|DRUG: Lu AG06466 Tablet|DRUG: Antacid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adolescent Girls Initiative for Learning and Empowerment: Impact Evaluation of a Safe Space-Based Life Skills Training and Digital Literacy Training in Nigeria Space-Based Life Skills Training and Digital Literacy Training in Nigeria
Status: RECRUITING
Conditions: Adolescent Behavior|Life Skills|Digital Skills|Sexual and Reproductive Health|Earning Outcomes
Interventions: OTHER: Safe Space based life skills training program|OTHER: Safe Space based life skills training program + Digital Skills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Seniors' Intraoperative Management Under Locoregional Anesthesia Integrating Virtual Reality
Status: NOT_YET_RECRUITING
Conditions: Virtual Reality|Spinal Anesthesia
Interventions: DEVICE: Virtual Reality Headset
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Does Subtotal Cholecystectomy Rate for Acute Cholecystitis Change With a Previous ERCP?
Status: COMPLETED
Conditions: Cholecystectomy, Laparoscopic|Cholangiopancreatography, Endoscopic Retrograde
Interventions: PROCEDURE: ERCP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Behavioral Weight Loss Intervention Utilizing Mobile Health Technology in Hematopoietic Stem Cell Transplant Patients
Status: RECRUITING
Conditions: Obesity|Stem Cell Transplant
Interventions: BEHAVIORAL: W8L2G mobile health (mHealth) app
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Thromboprophylaxis in Lower Limb Immobilisation
Status: NOT_YET_RECRUITING
Conditions: Thrombosis|Injury Leg
Interventions: DRUG: Rivaroxaban|DRUG: Apixaban|DRUG: Enoxaparin Injectable Solution|DRUG: Tinzaparin Injectable Solution|DRUG: Dalteparin Injectable Solution|DRUG: Fondaparinux Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pediatric Oncology Nutrition Intervention Trial
Status: RECRUITING
Conditions: Pediatric Cancer|Nutrition Related Cancer|Nutrition Aspect of Cancer|Muscle Loss|Malnutrition, Child
Interventions: DIETARY_SUPPLEMENT: Oral Nutrition Supplement|DIETARY_SUPPLEMENT: Tube Feed|DRUG: Cyproheptadine|DRUG: Olanzapine|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chest CT for the Placement of the Uniblocker
Status: COMPLETED
Conditions: Therapeutic Procedural Complication
Interventions: DEVICE: video laryngoscope and chest CT iminge|DEVICE: Conventional intubation of uniblocker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Polidocanol Endovenous Microfoam (PEM) Versus Vehicle for the Treatment of Saphenofemoral Junction (SFJ) Incompetence
Status: COMPLETED
Conditions: Varicose Veins
Interventions: DRUG: polidocanol injectable foam, 0.125%|DRUG: polidocanol injectable foam, 0.5%|DRUG: polidocanol injectable foam, 1.0%|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of Mp-MRI, MR-guided Biopsy, and Molecular Markers for Active Surveillance of Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: Multiparametric MRI|DIAGNOSTIC_TEST: Radiomics|DIAGNOSTIC_TEST: MR-guided Biopsy|DIAGNOSTIC_TEST: Molecular Markers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Emotional Memory Reactivation in Posttraumatic Stress Disorder
Status: TERMINATED
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: AVLOCARDYL|DRUG: Placebo|DRUG: AVLOCARDYL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Clinical Effects of Escalating Doses of Clonidine in ICU Patients
Status: COMPLETED
Conditions: Delirium|Critical Illness
Interventions: DRUG: Clonidine (Catapresan®) 0,150 mg/ml, ampoule 1 ml
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Exploratory Study of FAPi PET/CT With Histopathology Validation in Patients With Various Cancers
Status: RECRUITING
Conditions: Bladder Carcinoma|Cervical Carcinoma|Cholangiocarcinoma|Hematopoietic and Lymphoid Cell Neoplasm|Hepatocellular Carcinoma|Malignant Adrenal Gland Neoplasm|Malignant Brain Neoplasm|Malignant Pleural Neoplasm|Malignant Skin Neoplasm|Malignant Solid Neoplasm|Malignant Testicular Neoplasm|Malignant Thymus Neoplasm|Neuroendocrine Neoplasm|Thyroid Gland Carcinoma|Urothelial Carcinoma|Cancer of Unknown Primary Site
Interventions: PROCEDURE: Computed Tomography|DRUG: Gallium Ga 68 FAPi-46|PROCEDURE: Positron Emission Tomography|RADIATION: 18F-FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluate Safety and Immunogenicity of GSK Bio's Influenza Vaccine GSK576389A After Repeated Vaccination in Elderly Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: GSK Biologicals' influenza vaccine GSK576389A|BIOLOGICAL: Fluarix™
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections
Status: COMPLETED
Conditions: Acute Bacterial Skin and Skin Structure Infections
Interventions: DRUG: ceftobiprole medocaril|DRUG: vancomycin+aztreonam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ezetimibe Added to Statin Therapy (EASY) Study (0653-087)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: MK0653, ezetimibe / Duration of Treatment: 6 Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Anticoagulation Strategy for Acute Chest Syndrome
Status: COMPLETED
Conditions: Anemia|Sickle Cell|Acute Chest Syndrome|Low-Molecular-Weight Heparin
Interventions: DRUG: Prophylactic anticoagulation ( INNOHEP®)|DRUG: Curative anticoagulation ( INNOHEP®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Duloxetine for Succinylcholine-induced Postoperative Myalgia
Status: COMPLETED
Conditions: Postoperative Myalgia
Interventions: DRUG: Duloxetine|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Evaluation of MUC-1 CART in the Treatment of Intrahepatic Cholangiocarcinoma
Status: RECRUITING
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: BIOLOGICAL: MUC-1 CART cell immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Amlodipine/Benazepril on Albuminuria in Hypertensive Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Albuminuria
Interventions: DRUG: amlodipine/benazepril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Clonal Hematopoiesis and NETs Formation in Venous Thrombosis (CLODETTE)
Status: RECRUITING
Conditions: Venous Thromboses|Thromboembolic Disease|Neutrophil Extracellular Trap Formation|Clonal Hematopoiesis of Indeterminate Potential
Interventions: BIOLOGICAL: Additional blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: (68^Ga)-GaPSMA-11 PET/MR-imaging of Malignant Intra-axial Brain Tumors
Status: COMPLETED
Conditions: Malignant Brain Tumors
Interventions: PROCEDURE: intra-arterial injection|DEVICE: synchronous PET/MRI scan|OTHER: Radiopharmacon Contrast agent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Problem Adaptation Therapy for Mild Cognitive Impairment and Depression
Status: ACTIVE_NOT_RECRUITING
Conditions: Cognitive Impairment|Depression
Interventions: BEHAVIORAL: PATH-MCI|BEHAVIORAL: Supportive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Reduction of Risk Factors for ACL Re-injuries Using a Novel Biofeedback Approach
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injury
Interventions: OTHER: Biofeedback Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgery Versus Best Medical Management for the Long Term Remission of Type 2 Diabetes and Related Diseases (REMISSION)
Status: RECRUITING
Conditions: Bariatric Surgery Candidate|Diabetes
Interventions: PROCEDURE: Sleeve Gastrectomy|PROCEDURE: Roux-en-Y Gastric Bypass|PROCEDURE: Biliopancreatic Diversion with Duodenal Switch|OTHER: Medical management
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Right Ventricular Responses to Mild Hypercarbia After Mitral Valve Repair Surgery
Status: COMPLETED
Conditions: Heart; Decompensation, Right Ventricle|Echocardiography|Hypercapnia
Interventions: PROCEDURE: Hypercarbia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Evaluate the Safety, Tolerability, PK and PD in Cystic Fibrosis Patients With at Least 1 G542X Allele
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: ELX-02|DRUG: Ivacaftor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Aromatherapy Versus Placebo for Port-a-Cath Placement Under Monitored Anesthesia Care. A Randomized Controlled Trial
Status: COMPLETED
Conditions: Cancer Pain
Interventions: OTHER: ELEQUIL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pilot Study of Oxytocin and microRNA Identification in NAF, Serum, and Tissue in Women With Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer|Ductal Carcinoma in Situ
Interventions: DRUG: Intranasal Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ABP-671
Status: COMPLETED
Conditions: Hyperuricemia|Gout
Interventions: DRUG: ABP-671|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Childhood Germ Cell Tumor|Extragonadal Germ Cell Tumor|Ovarian Cancer|Retinoblastoma|Testicular Germ Cell Tumor|Unspecified Adult Solid Tumor, Protocol Specific|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: filgrastim|DRUG: thiotepa|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of Pexa-Vec Oncolytic Virus in Combination With Immune Checkpoint Inhibition in Refractory Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Colorectal Carcinoma|Colorectal Adenocarcinoma|Refractory Cancer|Colorectal Neoplasms
Interventions: DRUG: Durvalumab|DRUG: Tremelimumab|BIOLOGICAL: Pexa-Vec|BIOLOGICAL: Pexa-Vec
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phosphodiesterase Type 5 Inhibitors in Patients With Group 2 Pulmonary Hypertension
Status: RECRUITING
Conditions: Group 2 Pulmonary Hypertension
Interventions: DRUG: tadalafil 20 mg then 40 mg if tolerated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Human Diaphragm Strength by Magnetic and Electric Stimulation After Ultrasonography Phrenic Nerve Tracking
Status: COMPLETED
Conditions: Intensive Care Unit|Invasive Mechanical Ventilation
Interventions: PROCEDURE: Magnetic stimulation|PROCEDURE: Electric stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rehabilitation for Survivors of Cardiac Arrest Focused on Fatigue
Status: COMPLETED
Conditions: Cardiac Arrest With Successful Resuscitation
Interventions: OTHER: SCARF (Survivors of Cardiac Arrest Rehabilitation focused on Fatigue)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Argon Laser Peripheral Iridoplasty for Primary Angle Closure Glaucoma
Status: UNKNOWN
Conditions: Glaucoma
Interventions: PROCEDURE: Argon Laser Iridoplasty|DRUG: Travatan/ Timolol/Azopt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Impact of TTNS on Bladder Symptoms Among People With MS, A RCT
Status: RECRUITING
Conditions: Overactive Bladder Syndrome
Interventions: DEVICE: Active Transcutaneous Electrical Nerve Stimulation (TENS)|DEVICE: Sham Transcutaneous Electrical Nerve Stimulation (TENS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Massage on the Bilirubin Level in Term Infants Receiving Phototherapy
Status: COMPLETED
Conditions: Hyperbilirubinemia, Neonatal
Interventions: PROCEDURE: Baby massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: VICTORION-ASCERTAIN: Implementation Study (v-ASCERTAIN)
Status: RECRUITING
Conditions: Atherosclerotic Cardiovascular Disease (ASCVD)|Coronary Heart Disease (CHD)|Cerebrovascular Disease|Peripheral Arterial Disease (PAD)
Interventions: DRUG: Inclisiran Prefilled Syringe|OTHER: SMS messages|OTHER: Telephone-based support calls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of Oral BT-11 in Crohn's Disease Patients With Moderate to Severe Disease
Status: WITHDRAWN
Conditions: Crohn's Disease
Interventions: DRUG: BT-11|DRUG: Active comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Mindfulness and Yoga on Preschool Students' Emotional Regulation, Behavior, and Social Participation
Status: NOT_YET_RECRUITING
Conditions: Prosocial Behavior|Self Regulation|Impulsive Behavior
Interventions: BEHAVIORAL: Calm & Alert yoga and mindfulness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: COVID-19 Administration of Single-Dose Subcutaneous Anti- Spike(s) SARS-CoV-2 Monoclonal Antibodies Casirivimab and Imdevimab in High-Risk Pediatric Participants Under 12 Years of Age
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: casirivimab+imdevimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety/Efficacy Study of Alprostadil Liposomes for Injection to Treat Lower Extremity Arteriosclerosis Obliterans
Status: UNKNOWN
Conditions: Arteriosclerosis Obliterans
Interventions: DRUG: Alprostadil Liposomes for Injection|DRUG: Alprostadil Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Post-market Study Of Use Of The OMNI® Surgical System In Open Angle Glaucoma
Status: TERMINATED
Conditions: Glaucoma, Open-Angle
Interventions: DEVICE: OMNI® Surgical System|DEVICE: iStent inject
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of AQUAVAN® Injection Versus Midazolam HCl for Sedation in Patients Undergoing Elective Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy|Colon Polyps
Interventions: DRUG: fospropofol disodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Reiki Application on Pain, Fatigue and Sleep Quality in Elderly Persons Staying in Nursing Homes
Status: COMPLETED
Conditions: Pain|Tiredness|Sleep Quality
Interventions: BEHAVIORAL: pain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Moringa Leaf Capsules on Glycemic Control of Type 2 Diabetic Patients
Status: ENROLLING_BY_INVITATION
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Best African American Response to Asthma Drugs
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Flovent Diskus® 100 mcg|DRUG: Flovent Diskus® 250 mcg|DRUG: Flovent Diskus® 500 mcg|DRUG: Advair Diskus® 100/50 mcg|DRUG: Advair Diskus® 250/50 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Platelet Rich Fibrin (PRF) in Treatment of Non-healing Sternum Wound After Open-heart Surgery
Status: UNKNOWN
Conditions: Sternal Wound Repair
Interventions: BIOLOGICAL: PRF|BIOLOGICAL: placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The 3DKnee™ System: A Post-Market Study
Status: COMPLETED
Conditions: Osteoarthritis|Rheumatoid Arthritis|Post Traumatic Arthritis|Varus Deformity|Avascular Necrosis
Interventions: DEVICE: 3DKnee
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BromAc for Recurrent Peritoneal Mucinous Tumour or Pseudomyxoma Peritonei
Status: UNKNOWN
Conditions: Pseudomyxoma Peritonei|Peritoneal Cancer|Mucinous Adenocarcinoma|Mucinous Tumor
Interventions: DRUG: Bromelain|DRUG: Acetylcysteine|PROCEDURE: Interventional radiology insertion of drain
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RC48 Combined With Adebrelimab, Apatinib and S-1 as Neoadjuvant Therapy in Locally Advanced Gastric Cancer
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer/Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: RC48|DRUG: Adebrelimab|DRUG: Apatinib|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Posterior Capsule Opafication of Two Different Hydrophobic Acrylic Intraocular Lenses
Status: COMPLETED
Conditions: Age Related Cataracts
Interventions: DEVICE: Alcon SN60WF|DEVICE: Hoya Vivinex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Durvalumab With or Without Tremelimumab in Metastatic Castration Resistant Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Durvalumab|DRUG: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Walking Exercise in Improving Depression in Older Adults With Major Depressive Disorder, A Pilot Study
Status: COMPLETED
Conditions: Major Depressive Disorder (MDD)
Interventions: BEHAVIORAL: Waitlist control|BEHAVIORAL: Moderate-intensity walking exercise|BEHAVIORAL: Vigorous-intensity walking exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Single Dose Safety, Tolerability and Pharmacokinetics of IV BCX4430
Status: COMPLETED
Conditions: Marburg Virus Disease
Interventions: DRUG: galidesivir|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I, Single-Center Study of PDC-APB in Healthy Volunteers
Status: COMPLETED
Conditions: Contact Dermatitis
Interventions: DRUG: PDC-APB|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: EGFR-TKIs Combine With Anlotinib as First-line Treatment for Patients With Advanced EGFR Mutation-positive NSCLC
Status: UNKNOWN
Conditions: EGFR Gene Mutation
Interventions: DRUG: erlotinib or gefitinib or icotinib|DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Study to Evaluate the Safety, Tolerability, and Efficacy of Subcutaneous Zilucoplan in Participants With Generalized Myasthenia Gravis Who Were Previously Receiving Intravenous Complement Component 5 Inhibitors
Status: ACTIVE_NOT_RECRUITING
Conditions: Generalized Myasthenia Gravis
Interventions: DRUG: zilucoplan (RA101495)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PGE1 as Additive Anticoagulant in ECMO-Therapy
Status: TERMINATED
Conditions: Respiratory Distress Syndrome, Adult|Extracorporeal Membrane Oxygenation
Interventions: DRUG: Alprostadil|DRUG: 0.9% sodium chloride solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retrograde Autologous Priming and Mannitol for Reducing Hemodilution in Cardiac Surgery
Status: WITHDRAWN
Conditions: Hemodilution|Coronary Artery Disease|Fluid Overload
Interventions: PROCEDURE: Retrograde autologous priming|DRUG: Mannitol|PROCEDURE: Conventional Priming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Core Stability Training on Balance in Children With Adolescent Idiopathic Scoliosis
Status: UNKNOWN
Conditions: Adolescent Idiopathic Scoliosis
Interventions: OTHER: Home Based Traditional Scoliosis Exercises|OTHER: Core Stability Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of CS-3150 in Patients With Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: CS-3150|DRUG: Eplerenone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RECOVER-ENERGIZE Platform Protocol_Appendix B (Structured Pacing (PEM))
Status: RECRUITING
Conditions: Long COVID|Long Covid19|Long Covid-19
Interventions: BEHAVIORAL: Structured Pacing|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treating Tinnitus Using the Neuromonics Tinnitus Treatment Program: A Randomized, Double-blind Study
Status: UNKNOWN
Conditions: Tinnitus
Interventions: DEVICE: Neuromonics Tinnitus Treatment Program|DEVICE: Placebo Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Antiangiogenic Treatment of Hepatocellular Cancer With Bevacizumab and RAD001
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Everolimus, Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Amongst Scleral, Corneal and Amniotic Membrane Grafts to Restore Scleral Thinning
Status: UNKNOWN
Conditions: Scleral Thinning
Interventions: PROCEDURE: Human Amniotic Membrane Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Follow-up Study of Frozen-thawed Embryo Transfer (FTET) Cycles After Cryopreservation of Embryos in Clinical Trial P05787 (P05716)
Status: COMPLETED
Conditions: In Vitro Fertilization
Interventions: DRUG: 150 µg Corifollitropin Alfa|BIOLOGICAL: 200 IU RecFSH/Follitropin beta (Days 1 to 7)|DRUG: Placebo for Corifollitropin Alfa|DRUG: Placebo for RecFSH/Follitropin beta|BIOLOGICAL: 200 IU RecFSH/Follitropin beta (Days 8 to hCG)|DRUG: Ganirelix|BIOLOGICAL: hCG|BIOLOGICAL: Progesterone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Toripalimab Combined With Neoadjuvant Chemoradiotherapy as First-line Treatment for Locally Advanced，High-Risk，MSS Rectal Cancer
Status: RECRUITING
Conditions: Locally Advanced|High-Risk|Rectal Cancer|MSS
Interventions: DRUG: Toripalimab|RADIATION: short-term radiotherapy|DRUG: Oxaliplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Step Count on Edema After Rhinoplasty
Status: RECRUITING
Conditions: Reduce Edema and Ecchymosis After Rhinoplasty
Interventions: PROCEDURE: rhinoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Belatacept Post Depletional Repopulation to Facilitate Tolerance
Status: COMPLETED
Conditions: Organ Transplantation
Interventions: DRUG: Belatacept|DRUG: Sirolimus|DRUG: Alemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Effectiveness of Novantrone Therapy Followed by Copaxone for Multiple Sclerosis.
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: glatiramer acetate 20 mg|DRUG: glatiramer acetate 20 mg, with mitoxantrone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC