pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Ventricular Tachyarrhythmia Detection by Implantable Loop Recording in Patients With Heart Failure and Preserved Ejection Fraction
Status: COMPLETED
Conditions: Heart Failure With Preserved Ejection Fraction (HFpEF)
Interventions: DEVICE: ILR implantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Continuous Glucose Monitoring Combined With Computer Algorithm for Intensive Insulin Therapy in Cardiosurgical Patients
Status: COMPLETED
Conditions: Hyperglycemia|Cardiac Surgery
Interventions: DEVICE: Continuous glucose monitoring system combined with enhanced model predictive control algorithm for intensive insulin treatment|OTHER: Intensive insulin therapy using standard protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Study to Assess the Absolute Bioavailability of Tasimelteon (HETLIOZ™)
Status: COMPLETED
Conditions: Non-24-Hour-Sleep-Wake Disorder
Interventions: DRUG: tasimelteon 20 mg capsule|DRUG: tasimelteon 2 mg I.V.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interventions for Moderate Malnutrition in Pregnancy
Status: COMPLETED
Conditions: Pregnancy|Moderate Malnutrition
Interventions: DIETARY_SUPPLEMENT: ready-to-use supplementary food|DIETARY_SUPPLEMENT: corn-soy blend|DIETARY_SUPPLEMENT: iron|DIETARY_SUPPLEMENT: folic acid|DIETARY_SUPPLEMENT: UNIMMAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy In Locally Advanced Rectal Cancer
Status: COMPLETED
Conditions: Colon Rectal Cancer
Interventions: DRUG: Avelumab|DRUG: Capecitabine|RADIATION: EXTERNAL---BEAM IRRADIATION 50.4 GY
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Massage of Maxillofacial and Oral Cavity to Prevent Radioactive Oral Mucositis
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma
Interventions: OTHER: Massage of Maxillofacial and Oral Cavity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Remote Ischemic Postconditioning on Autonomic Function in Stroke Patients
Status: UNKNOWN
Conditions: Ischemic Stroke
Interventions: PROCEDURE: remote ischemic postconditioning|PROCEDURE: sham remote ischemic postconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of Protein Metabolism, Microbiome and Investigational Probiotic Use in Patients With ALS
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis|ALS
Interventions: DIETARY_SUPPLEMENT: probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation to Demonstrate the Safety and Performance of the Candela PicoWay System™
Status: ACTIVE_NOT_RECRUITING
Conditions: Wrinkle|Pigmented Lesions
Interventions: DEVICE: PicoWay Laser System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of SBP-101 Combined With Nab-Paclitaxel and Gemcitabine in Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer Metastatic|Pancreatic Cancer Stage IV|Stage IV Pancreatic Cancer
Interventions: DRUG: SBP-101|DRUG: nab-paclitaxel|DRUG: Gemcitabine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Response to COVID-19 Vaccine in Multiple Sclerosis Patients Treated With Teriflunomide and Alemtuzumab
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: BIOLOGICAL: COVID-19 vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Percutaneous Localization: Open-label Registry of Thoracic Surgery
Status: COMPLETED
Conditions: Lung Lesion(s) Requiring Evaluation|Pulmonary Metastasis|Pulmonary Nodule, Solitary|Peripheral Lung Lesions
Interventions: PROCEDURE: Percutaneous localization of suspicious lung lesion(s) using electromagnetic navigation and tools.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase II Study to Evaluate Efficacy and Safety of D-0120 in Combination With Allopurinol in Subjects With Gout
Status: RECRUITING
Conditions: Gout
Interventions: DRUG: D-0120|DRUG: Allopurinol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long Term Follow up of Children Enrolled in the REDvent Study
Status: RECRUITING
Conditions: Respiratory Distress Syndrome, Adult|Ventilator-Induced Lung Injury|Neurocognitive Dysfunction|Quality of Life|Respiration Disorders
Interventions: DIAGNOSTIC_TEST: Ventilation Inhomogeneity|DIAGNOSTIC_TEST: Diaphragm Ultrasound|DIAGNOSTIC_TEST: Respiratory Inductance Plethysmography|DIAGNOSTIC_TEST: Spirometry|DIAGNOSTIC_TEST: Functional Residual Capacity|DIAGNOSTIC_TEST: MIP/MEP|DIAGNOSTIC_TEST: 6 minute walk test|DIAGNOSTIC_TEST: Neurocognitive Testing|DIAGNOSTIC_TEST: Emotional Health Assessment|DIAGNOSTIC_TEST: Health Related Quality of Life|DIAGNOSTIC_TEST: Functional Status|DIAGNOSTIC_TEST: Respiratory Status Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Oxybutynin for Post-surgical Bladder Pain and Urgency
Status: RECRUITING
Conditions: Overactive Bladder Syndrome|Neuropathic Bladder
Interventions: DRUG: Oxybutynin Transdermal Patch|DRUG: Oral Oxybutynin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Trial of Brentuximab Vedotin(SGN-35) Versus Physician's Choice (Methotrexate or Bexarotene) in Participants With CD30-Positive Cutaneous T-Cell Lymphoma (ALCANZA Study)
Status: COMPLETED
Conditions: Primary Cutaneous Anaplastic Large Cell Lymphoma|Mycosis Fungoides|Cutaneous T-Cell Lymphoma
Interventions: DRUG: Brentuximab Vedotin|DRUG: Methotrexate|DRUG: Bexarotene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of "Multi-Immunotherapy Special Training Courses Through Digital Media and Workshop" Intervention for Oncology Nurses: Exploration of Educational Needs, Curriculum Planning, Implementation and Evaluation
Status: COMPLETED
Conditions: Education|Oncology|Immune
Interventions: OTHER: Immunotherapy Special Training Course (ISTC)|OTHER: Advanced Oncology Nurse Training Course (AONTC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Iron Bioavailability From Cubes
Status: COMPLETED
Conditions: Iron Deficiency
Interventions: DIETARY_SUPPLEMENT: Bouillon fortified with FePP|DIETARY_SUPPLEMENT: Bouillon fortified with FePP + Stabilizer|DIETARY_SUPPLEMENT: Bouillon fortified with FeSO4|DIETARY_SUPPLEMENT: Bouillon fortified with FeSO4 + Stabilizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Multicenter Randomized Double-blind Placebo-controlled Pilot Study of Safety, Pharmacodynamics and Efficacy of Different Treatments of Immunotherapeutic Drug Mobilan (M-VM3) in Patients With Diagnosed Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DRUG: Mobilan (M-VM3)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intradermal Acupuncture on Gallbladder Meridian Points on Cerebral Hemodynamics in Relevant Brain Regions for Major Depressive Disorder Based on fNIRS Technology
Status: NOT_YET_RECRUITING
Conditions: Major Depressive Disorder
Interventions: PROCEDURE: Intradermal acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Pre-exposure Prophylaxis Cascade in Pregnant and Breastfeeding Women in Cape Town (Formative Study)
Status: COMPLETED
Conditions: Hiv
Interventions: DRUG: TDF-FTC|BEHAVIORAL: Counselling on PrEP in antenatal and postnatal care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Gastrointestinal Surgery Study Group 2001
Status: UNKNOWN
Conditions: Gastrostomy|Computed Tomography Angiography|Clinical Outcome
Interventions: DEVICE: CT angiography（CTA）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Weekly Hippotherapy Frequency on Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: Hippotherapy once a week|OTHER: Hippotherapy twice a week
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Pulsed Electromagnetic Fields (PEMF) After Breast Reconstruction Surgery
Status: COMPLETED
Conditions: Other Reconstructive Surgery
Interventions: DEVICE: Sham PEMF Device|DEVICE: Ivivi Torino II PEMF Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Clinical Trial to Prevent Recurrent CA-MRSA Infection
Status: COMPLETED
Conditions: Methicillin Resistant Staphylococcus Aureus Skin Infections
Interventions: DRUG: mupirocin and chlorhexidine|BEHAVIORAL: household cleaning and disinfection|DRUG: mupirocin, chlorhexidine, & household cleaning/disinfection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dosage of Intrathecal Hyperbaric Bupivacaine and the Incidence of Post Spinal Shivering.
Status: COMPLETED
Conditions: Cesarean Section; Shivering
Interventions: DRUG: Low dose bupivacaine 0.5% (8mg)|DRUG: High dose bupivacaine 0.5% (10mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Ischemic Conditioning Chronic Stroke Study
Status: COMPLETED
Conditions: Stroke
Interventions: PROCEDURE: Ischemic Conditioning|PROCEDURE: Sham Ischemic Conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Recombinant Human Interleukin-7 (CYT107) on Tumor Clearance and Immune Reconstitution in Multiple Myeloma Patients After Autologous Hematopoietic Cell Transplant
Status: NOT_YET_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Recombinant glycosylated human interleukin-7|DRUG: Melphalan|PROCEDURE: Autologous hematopoietic cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of ADS-5102 in Multiple Sclerosis Patients With Walking Impairment
Status: COMPLETED
Conditions: Walking Impairment|Multiple Sclerosis
Interventions: DRUG: ADS-5102, 137 mg|DRUG: ADS-5102, 274 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of an Innovative Health Ingredient From Marine By-products for the Healthy Aging
Status: COMPLETED
Conditions: Memory Impairment|Age-related Cognitive Decline
Interventions: DIETARY_SUPPLEMENT: Blue fish hydrolysate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Allogenic Immunotherapy Based on Natural Killer (NK) Cell Adoptive Transfer in Metastatic Gastrointestinal Carcinoma Treated With Cetuximab
Status: COMPLETED
Conditions: Gastrointestinal Metastatic Cancer
Interventions: BIOLOGICAL: allogenic immunotherapy based on Natural Killer cells adoptive transfer|BIOLOGICAL: cetuximab|DRUG: Cyclophosphamide|DRUG: fludarabine|DRUG: interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction Study of Saxagliptin in Combination With Dapagliflozin in Healthy Participants
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Saxagliptin|DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Trial to Determine Efficacy of Fexinidazole in Visceral Leihmaniasis Patients in Sudan
Status: TERMINATED
Conditions: Visceral Leishmaniasis
Interventions: DRUG: Fexinidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sevoflurane Versus Intravenous Anaesthetic Agents in Morbid Obese Patients
Status: UNKNOWN
Conditions: Morbid Obesity
Interventions: DRUG: Sevoflurane|DRUG: Sevoflurane|DRUG: Propofol- Remifentanyl|DRUG: Propofol, Remifentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Levalbuterol Tartrate HFA Inhalation Aerosol Metered Dose Inhaler (MDI) in Pediatric Subjects
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: levalbuterol tartrate HFA inhalation aerosol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of [F 18]HX4 Positron Emission Tomography (PET) as a Tool to Detect Hypoxia in Tumors
Status: COMPLETED
Conditions: Head and Neck Cancer|Lung Cancer|Liver Cancer|Rectal Cancer|Cervical Cancer
Interventions: DRUG: [F 18]HX4
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Cardiovascular Risk in Sedentary Elderly During Prolonged Sitting Time Versus Intermittent Sitting Time
Status: UNKNOWN
Conditions: Sedentary Lifestyle
Interventions: OTHER: Prolonged sitting time|OTHER: PST+Light intensity Short bouts PA|OTHER: PST+Moderate intensity Short bouts PA|OTHER: PST+Moderate intensity Long bouts PA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Self-management of Low Back Pain in Horticulture Workers
Status: RECRUITING
Conditions: Back Pain
Interventions: BEHAVIORAL: Self-management videos|BEHAVIORAL: Check lists for ergonomic options|BEHAVIORAL: Text reminders|BEHAVIORAL: Video review
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: BAY88-8223, Does Response Study in HRPC Patients
Status: COMPLETED
Conditions: Hormone Refractory Prostate Cancer|Bone Metastases
Interventions: DRUG: Radium-223 dichloride (BAY88-8223)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of Two Initial Combination Therapies in Patients With Recent Onset Diabetes
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes (Adult Onset)
Interventions: DRUG: Tirzepatide|DRUG: Pioglitazone|DRUG: Sitagliptin|DRUG: Metformin HCI XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: An Early Feasibility Study Evaluating the Safety and Efficacy of the Laminar Left Atrial Appendage Closure System in Subjects With Non-Valvular Atrial Fibrillation
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-valvular Atrial Fibrillation
Interventions: DEVICE: Left Atrial Appendage Closure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bryostatin 1 Plus Paclitaxel in Treating Patients With Locally Advanced or Metastatic Esophageal Cancer or Stomach Cancer
Status: COMPLETED
Conditions: Esophageal Cancer|Gastric Cancer
Interventions: DRUG: bryostatin 1|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Naturally-derived Mouthrinse for Gingival Inflammation
Status: COMPLETED
Conditions: Gingivitis
Interventions: DRUG: Herbal API|DRUG: Cepacol|DRUG: Listerine Antiseptic Mouth Rinse|DRUG: placebo mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gambling and Brief Interventions
Status: COMPLETED
Conditions: Gambling
Interventions: BEHAVIORAL: 5 Minutes of Simple Advice|BEHAVIORAL: Motivational Enhancement Therapy (MET)|BEHAVIORAL: Cognitive Behavioral Therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Interferon Alfa With or Without Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: recombinant interferon alfa|BIOLOGICAL: sargramostim|DRUG: carmustine|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: melphalan|DRUG: methylprednisolone|DRUG: prednisone|DRUG: vincristine sulfate|RADIATION: low-LET cobalt-60 gamma ray therapy|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Endoscopic Necrosectomy Versus Step-up Endoscopic Intervention
Status: COMPLETED
Conditions: Pancreatic Necrosis|Necrosis Pancreas
Interventions: PROCEDURE: Direct Endoscopic Intervention|PROCEDURE: Step-up Endoscopic Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Veliparib and Whole Brain Radiation Therapy (WBRT) Versus Placebo and WBRT in Adults With Brain Metastases From Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Brain Metastases From Non-small Cell Lung Cancer
Interventions: DRUG: Veliparib|DRUG: Placebo|RADIATION: Whole brain radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Hematological Malignancies
Interventions: DRUG: Talquetamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medical Abortion With Mifepristone + Misoprostol (13 - 22 Weeks)
Status: COMPLETED
Conditions: Complete Uterine Evacuation After Use of Study Drugs
Interventions: DRUG: Mifepristone|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Triple Dye Plus Alcohol Versus Triple Dye Alone for Newborn Umbilical Cord Care
Status: COMPLETED
Conditions: Umbilical Cord|Infection
Interventions: PROCEDURE: Alcohol swab of umbilical cord
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Salvage Chemotherapy Versus Total Mesorectal Resection for Local Resection Rectal Cancer Patients
Status: RECRUITING
Conditions: Chemotherapy Effect|Rectal Cancer
Interventions: PROCEDURE: Radical total mesorectal excision|OTHER: Salavge Adjuvant Chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cooking and Nutrition Education for Health Among Adults With Diabetes
Status: COMPLETED
Conditions: Diabetes
Interventions: OTHER: Nutrition Education|OTHER: Cooking Lecture|OTHER: Cooking Demo|OTHER: Hands-on Cooking|OTHER: e-Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers That Predict Response to High-Dose Aldesleukin in Metastatic Kidney Cancer or Metastatic Melanoma
Status: COMPLETED
Conditions: Kidney Cancer|Melanoma (Skin)
Interventions: BIOLOGICAL: aldesleukin|GENETIC: gene expression analysis|GENETIC: mutation analysis|OTHER: flow cytometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Oxytocin on Obstructive Sleep Apnea Induced Changes in Sleep
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DRUG: Oxytocin Intranasal Spray|DRUG: Placebo Intranasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study on the Effect of High-concentrated Platelet Rich Plasma (PRP) on Osteoarthritis in the Thumb Base.
Status: RECRUITING
Conditions: Osteoarthritis Thumb
Interventions: PROCEDURE: Platelet rich plasma (PRP)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of JNJ 31001074 on Urge to Drink in Alcohol-Dependent Adults
Status: WITHDRAWN
Conditions: Alcoholism
Interventions: DRUG: JNJ-31001074|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Antithymocyte Globulin for Treatment of New-onset T1DM
Status: TERMINATED
Conditions: New-onset Type 1 Diabetes Mellitus
Interventions: DRUG: Antithymocyte globulin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Transcatheter Aortic Valve Replacement in Low-Risk Patients With Symptomatic, Severe Aortic Stenosis
Status: COMPLETED
Conditions: Aortic Stenosis
Interventions: DEVICE: Transfemoral TAVR|DEVICE: SAVR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Photobiomodulation Effect on Electroretinogram Outcomes in Dry Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Age Related Macular Degeneration
Interventions: DEVICE: Photobiomodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Using Fiducial Markers in Image Guided Volumetric Modulated Arc Therapy to the Focal Lesion Micro Boost of Localized Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Adenocarcinoma
Interventions: RADIATION: Dose escalation to prostate focal lesion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Daratumumab and Donor Lymphocyte Infusion in Treating Participants With Relapsed Acute Myeloid Leukemia After Stem Cell Transplant
Status: COMPLETED
Conditions: Minimal Residual Disease|Recurrent Acute Myeloid Leukemia With Myelodysplasia-Related Changes|Recurrent Adult Acute Myeloid Leukemia|Recurrent Childhood Acute Myeloid Leukemia
Interventions: BIOLOGICAL: Daratumumab|PROCEDURE: Donor Lymphocyte Infusion|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neo-Adjuvant FOLFOX for Rectal Carcinoma
Status: TERMINATED
Conditions: Rectal Neoplasms
Interventions: DRUG: FOLFOX|PROCEDURE: total mesorectal excision (TME)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Vardenafil on Clinical Symptoms and Peripheral Blood Flow in Patients With Raynaud's Syndrome
Status: COMPLETED
Conditions: Raynaud Syndrome
Interventions: DRUG: vardenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Positron Emission Tomography (PET) Tracer ZK 6032924 in Patients With Multiple Sclerosis Compared to Healthy Volunteers
Status: COMPLETED
Conditions: Positron-Emission Tomography|Multiple Sclerosis
Interventions: DRUG: F-18 FEDAA1106 (BAY85-8101)|DRUG: F-18 FEDAA1106 (BAY85-8101)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Gamified Network for Surgical Education During COVID-19: A Randomized Controlled Trial
Status: UNKNOWN
Conditions: Advanced Suturing Skills|Surgical Education
Interventions: OTHER: Learning running subcuticular sutures on the Gamified Educational Network
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of HPC-03 for Postmenopausal Symptom
Status: UNKNOWN
Conditions: Postmenopausal Period
Interventions: DIETARY_SUPPLEMENT: HPC-03|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relief of Migraine Pain Through Electro Stimulation
Status: COMPLETED
Conditions: Migraine Headache
Interventions: DEVICE: Randomized treatment/placebo delivery of transcutaneous electro stimulation via a dedicated device Avital.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide and Idelalisib in Treating Patients With Recurrent Follicular Lymphoma
Status: COMPLETED
Conditions: Recurrent Follicular Lymphoma
Interventions: DRUG: idelalisib|DRUG: lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrative Management of Patients With Atrial Fibrillation Via Hospital-Community-Family-Based Telemedicine (HCFT-AF) Program
Status: UNKNOWN
Conditions: Telemedicine|Atrial Fibrillation
Interventions: OTHER: Hospital-Community-Family-Care Management Platform Online|OTHER: Subjects with AF conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Artronat on the Quality of Life of Patient With Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DIETARY_SUPPLEMENT: ARTRONAT|DIETARY_SUPPLEMENT: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety of Ovarian Stimulation With Letrozole and Gonadotropins in Breast Cancer Patients
Status: TERMINATED
Conditions: Breast Cancer
Interventions: PROCEDURE: Ovarian stimulation in vitro fertilization cryopreservation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Mechanized Gait Trainer Combine Transcranial Galvanic Stimulation (tDCS) in Chronic Stroke
Status: COMPLETED
Conditions: Hemiparesis|Cerebrovascular Disorders
Interventions: DEVICE: GangTrainer and tDCS|DEVICE: control group1|OTHER: Control group2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hydralazine Valproate for Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: DRUG: Hydralazine and magnesium valproate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess if ABP 798 is Safe & Effective in Treating Moderate to Severe Rheumatoid Arthritis (RA) Compared to Rituximab
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: ABP 798|DRUG: Rituximab (US)|DRUG: Rituximab (EU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mebeverine For 1st Year Daytime And Nocturnal Incontinence After Orthotopic W-Ileal Neobladders
Status: COMPLETED
Conditions: Oncology|Incontinence|Incontinence, Daytime Urinary|Incontinence, Nighttime Urinary|Bladder Cancer|Orthotopic Neobladder
Interventions: DRUG: Coloverin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: High Dose SBRT for Abdominal-Pelvic Lymph Nodal Lesions in Oligometastatic Patients
Status: UNKNOWN
Conditions: Lymph Node Cancer Metastatic
Interventions: RADIATION: Oligometastatic patients with abdominal-pelvic lymph nodes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RAPA-501-Allo Therapy of COVID-19-ARDS
Status: TERMINATED
Conditions: Severe COVID-19 Disease
Interventions: BIOLOGICAL: RAPA-501-Allo off-the-shelf Therapy of COVID-19|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prevalence of FGIDs and Probiotics Study
Status: RECRUITING
Conditions: Functional Gastrointestinal Disorders|Infant Conditions
Interventions: DIETARY_SUPPLEMENT: Biogaia|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relaxation Intervention in Patients With Diabetic Foot Ulcer
Status: COMPLETED
Conditions: Diabetes Mellitus|Diabetic Foot Ulcer
Interventions: BEHAVIORAL: Muscle Relaxation with Guided Imagery|BEHAVIORAL: Neutral Guided Imagery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Repetitive Transcranial Magnetic Stimulation (rTMS) as Adjuvant Treatment for Depression
Status: TERMINATED
Conditions: Depression
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Software for Patients With Stroke
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: DEVICE: META QUEST 3 virtual reality glasses|DEVICE: Nintendo Switch (Nintendo Co., Ltd, Kyoto, Japan)|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Liraglutide Treatment on Postprandial Chylomicron and VLDL Kinetics, Liver Fat and de Novo Lipogenesis
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Liraglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pioglitazone Versus Metformin in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Pioglitazone|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Marginal Fit of Porcelain Veneers After Finishing Prepared Surfaces With Ultrasonic Tips
Status: COMPLETED
Conditions: Tooth Discoloration
Interventions: PROCEDURE: Ultrasonic tips
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cadonilimab in Patients (Pts) With Advanced Non-small Cell Lung Cancer (NSCLC)
Status: ACTIVE_NOT_RECRUITING
Conditions: NSCLC Stage IV|NSCLC Stage IIIB|NSCLC Stage IIIC
Interventions: DRUG: Cadonilimab|DRUG: Anlotinib|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Letrozole 2.5 mg Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Femara (Sequence 1)|DRUG: Peratra (Sequence 1)|DRUG: Femara (Sequence 2)|DRUG: Peratra (Sequence 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Trial to Demonstrate That the Dual Laser Therapy is Effective for the Treatment of Vulvar Lichen Sclerosus
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Skin Disease|Vulvar Lichen Sclerosus
Interventions: DEVICE: FotonaSmooth SP® Spectro laser device|DRUG: Clobetasol propionate 0.05% ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient-Centric Innovation: Superior Vena Cava Approach in Zero-Fluoroscopy
Status: COMPLETED
Conditions: Atrioventricular Nodal Reentrant Tachycardia
Interventions: PROCEDURE: Zero-Fluoroscopy Radiofrequency Catheter Ablation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Open-Label Study to Assess Safety
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Topical TA-102 A|DRUG: Topical TA-102 B|DRUG: Topical TA-102 C|DRUG: Topical TA-102 D|DRUG: Topical TA-102 E
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving South African Government Workers' Capacities to Deliver HIV Interventions
Status: UNKNOWN
Conditions: HIV|Partner Violence|Malnutrition|Alcohol Use/Abuse|Depression
Interventions: BEHAVIORAL: Accountable Condition|BEHAVIORAL: Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Investigation Into Inhaled Treprostinil Sodium in Patients With Severe Pulmonary Arterial Hypertension (PAH)
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Inhaled treprostinil|DRUG: Placebo inhalation solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral Enteral Nutrition on Cerebral Small Vessel Disease
Status: COMPLETED
Conditions: Cerebral Small Vessel Diseases
Interventions: DEVICE: Intermittent Oro-esophageal Tube|DEVICE: Nasogastric tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Efficacy and Complication of Gentamicin Nasal Irrigation in Chronic Rhinosinusitis and Recurrent Sinusitis
Status: UNKNOWN
Conditions: Rhinosinusitis
Interventions: DRUG: Gentamicin nasal irrigation|DRUG: Normal saline nasal irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of a Single Dose of REGN88(SAR153191)in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: REGN88|BIOLOGICAL: REGN88|BIOLOGICAL: REGN88
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The With Or Without Olecranon K-wires Trial
Status: RECRUITING
Conditions: Olecranon Fracture
Interventions: PROCEDURE: Cerclage fixation|PROCEDURE: Tension band wiring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Endoscopic Ultrasound-Guided Portal Pressure Measurements to Guide Beta-Blocker Therapy in Patients With Compensated Cirrhosis
Status: NOT_YET_RECRUITING
Conditions: Cirrhosis|Compensated Cirrhosis|Portal Hypertension
Interventions: DIAGNOSTIC_TEST: EUS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diet and Vascular Health Study
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: Diet and Vascular Health|DIETARY_SUPPLEMENT: Diet and Vascular Health|DIETARY_SUPPLEMENT: Diet and Vascular Health Study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetic Interaction and Safety/Tolerability Between NVP-1603-1 and NVP-1603-2
Status: WITHDRAWN
Conditions: Healthy
Interventions: DRUG: NVP-1603-1 (P)|DRUG: NVP-1603-2 (T)|DRUG: NVP-1603-1 and NVP-1603-2 (P+T)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Trial of Bevacizumab and Temsirolimus in Combination With 1) Carboplatin, 2) Paclitaxel, 3) Sorafenib for the Treatment of Advanced Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Cancer
Interventions: DRUG: Temsirolimus|DRUG: Bevacizumab|DRUG: Paclitaxel|DRUG: Sorafenib|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Saccharomyces Boulardii for Gastrointestinal Bacterial-overgrowth in Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis|Small Intestinal Bacterial Overgrowth
Interventions: DRUG: Saccharomyces Boulardii Oral Tablet|DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PankoMab-GEX™ Versus Placebo as Maintenance Therapy in Advanced Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Epithelial Cancer Recurrent|Fallopian Tube Cancer|Primary Peritoneal Cancer
Interventions: DRUG: PankoMab-GEX|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determine the Safety and Dose of EN001 in Patients With Duchenne Muscular Dystrophy(DMD)
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: EN001|DRUG: EN001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of SEA-CD40 in Cancer Patients
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung|Carcinoma, Squamous Cell|Hodgkin Disease|Lymphoma|Lymphoma, B-Cell|Lymphoma, Follicular|Lymphoma, Large B-Cell, Diffuse|Melanoma|Neoplasm Metastasis|Neoplasms, Head and Neck|Neoplasms, Squamous Cell|Non-Small Cell Lung Cancer|Non-Small Cell Lung Cancer Metastatic|Non-small Cell Carcinoma|Squamous Cell Cancer|Squamous Cell Carcinoma|Squamous Cell Carcinoma of the Head and Neck|Squamous Cell Neoplasm|Lymphoma, Non-Hodgkin|Pancreatic Adenocarcinoma
Interventions: DRUG: Intravenous (IV) SEA-CD40|DRUG: Pembrolizumab|DRUG: Subcutaneous (SC) SEA-CD40|DRUG: Gemcitabine|DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mid- or High-flex Rods Versus Low-flex Rods of SpineShape System IV for Treatment of Degenerative Lumbar Spine Diseases
Status: RECRUITING
Conditions: Degenerative Lumbar Spinal Stenosis|Facet Joint Arthrosis|Spondylarthritis|Discopathy|Degenerative Spondylolisthesis|Instability Lumbar Spine
Interventions: DEVICE: SpineShape System IV straight rod elastic|DEVICE: SpineShape System IV straight rod medium|DEVICE: SpineShape System IV straight rod stiff
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vitamin B6 in Reducing Hot Flashes in Participants With Prostate Cancer Undergoing Antiandrogen Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Hot Flashes|Prostate Carcinoma
Interventions: DIETARY_SUPPLEMENT: Vitamin B6|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Entecavir and Peginterferon Therapy in HBeAg-Positive Immune-Tolerant Adults With Chronic Hepatitis B
Status: TERMINATED
Conditions: Hepatitis B
Interventions: DRUG: Entecavir and peginterferon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Interlocking Detachable Coils System in Embolization of Peripheral Arterial Embolization
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: Interlocking detachable coils system|DEVICE: Interlock Fibered IDC Occlusion System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of K-321 Eye Drops After Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD)
Status: RECRUITING
Conditions: Fuchs Endothelial Corneal Dystrophy
Interventions: DRUG: Ripasudil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Genetic Mapping for Cardiac Risk Assessment
Status: UNKNOWN
Conditions: Angina Pectoris|Myocardial Infarction|Coronary Disease|Myocardial Ischemia|Acute Coronary Syndrome
Interventions: BIOLOGICAL: MULTIGENE SCREENING FOR SINGLE SNPS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of DHA On Reducing Early Preterm Birth
Status: COMPLETED
Conditions: Preterm Birth
Interventions: DRUG: Docosahexaenoic acid - 800mg/day|DRUG: Docosahexaenoic acid - 200mg/day|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial of Naltrexone/Bupropion for the Treatment of Methamphetamine Use Disorder
Status: RECRUITING
Conditions: Methamphetamine-dependence|Methamphetamine Abuse
Interventions: DRUG: extended-release naltrexone (XR-NTX)|DRUG: extended release bupropion (BUP-XL) tablets (BUP-XL)|DRUG: iPLB|DRUG: oPLB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Comparison Between the Stand-alone Cage and the Autologous Iliac Bone Graft/Anterior Plating in the Single-level Surgical Treatment of the Cervical Spine
Status: COMPLETED
Conditions: Cervical Vertebrae|Single|Degenerative Disease
Interventions: PROCEDURE: Cage fusion|PROCEDURE: Plate fusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: R-ACVBP Versus R-CHOP in Patients Aged 60-65 With Diffuse Large B-cell Lymphoma
Status: TERMINATED
Conditions: Lymphoma, Large-Cell, Diffuse
Interventions: DRUG: Rituximab|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Vindesine|DRUG: Bleomycin|DRUG: Prednisone|DRUG: Prednisone|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Imaging and Pharmacodynamic Trial of CS-1008 in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: DRUG: CS-1008
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block Versus Oblique-Subcostal Transversus Abdominis Plane Block in Emergency Abdominal Surgery With Midline Incision
Status: NOT_YET_RECRUITING
Conditions: Pain, Postoperative|Abdominal Surgery|Emergency
Interventions: PROCEDURE: TAPB|BIOLOGICAL: ESPB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION