pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluation of Safety & Tolerability of Multiple Dose Regimens of CHF 5074 and Exploration of Effects on Potential Markers of Clinical Efficacy in Patients With Mild Cognitive Impairment - Open Label Extension (CT04 OLEP)
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: CHF 5074 1x|DRUG: CHF 5074 2x|DRUG: CHF 5074 3x
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Two Strategies of Chemotherapy for Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Metastasis
Interventions: DRUG: 5-fluorouracil|DRUG: leucovorin|DRUG: irinotecan|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flumazenil for Hypoactive Delirium Secondary to Benzodiazepine Exposure
Status: TERMINATED
Conditions: Hypoactive Delirium
Interventions: DRUG: Flumazenil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Ureteroscopic Treatment of Nephrolithiasis With and Without Moses Technology
Status: COMPLETED
Conditions: Nephrolithiasis
Interventions: DEVICE: Holmium laser lithotripsy with Moses Technology|DEVICE: Holmium laser lithotripsy without Moses Technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of VA-CAG as Induction Therapy in Newly Diagnosed AML Patients
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Venetoclax in combination with azacitidine and CAG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lapatinib Plus Caelyx in Patients With Advanced Metastatic Breast Cancer Following Failure of Trastuzumab Therapy
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: doxorubicinhydrochloride, Lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine as an Adjuvant for Sub-Tenon's Anesthesia
Status: COMPLETED
Conditions: Vitreoretinal Surgery Under Sub-Tenon's Anesthesia
Interventions: DRUG: dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Strategies to Promote Cessation in Smokers Who Are Not Ready To Quit
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Brief Advice|BEHAVIORAL: Motivational Interviewing|BEHAVIORAL: Rate Reduction|DRUG: Pharmacological|BEHAVIORAL: MI+RR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization of the Pharmacokinetics of a Vaginal Ring With 2.0 g Progesterone in Post-menopausal Women
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Progesterone vaginal ring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Plyometric Training on Physical Fitness and Technical Skills in Young Male Volleyball Players.
Status: RECRUITING
Conditions: Physical Fitness|Technical Skills
Interventions: OTHER: Plyometric training|OTHER: Conventional
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: New Tools for Assessing Fracture Risk
Status: TERMINATED
Conditions: Osteoporosis|Fracture Risk Assessment
Interventions: DEVICE: Osteoprobe-Reference Point Indentation (RPI)|RADIATION: Dual-energy X-ray absorptiometry (DXA) Scans|RADIATION: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intranasal Dexmedetomidine Plus Ketamine for Procedural Sedation
Status: RECRUITING
Conditions: Fracture|Dislocation
Interventions: DRUG: IN Ketodex (D4K2)|DRUG: IN Ketodex (D3K3)|DRUG: IN Ketodex (D2K4)|DRUG: IV Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Olaparib and Radiotherapy in Head and Neck Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Laryngeal Cancer Stage II|Laryngeal Cancer Stage III|Carcinoma, Squamous Cell|Head and Neck Neoplasms
Interventions: RADIATION: radiotherapy|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer
Status: COMPLETED
Conditions: Rectal Adenocarcinoma|Stage II Rectal Cancer AJCC v7|Stage III Rectal Cancer AJCC v7
Interventions: DRUG: Capecitabine|DRUG: Fluorouracil|RADIATION: Intensity-Modulated Radiation Therapy|DRUG: Leucovorin|DRUG: Oxaliplatin|BIOLOGICAL: Pembrolizumab|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest of PET-PSMA Imaging Potentialised by Androgen Blockade in Localized Prostatic Adenocarcinoma
Status: UNKNOWN
Conditions: Prostate Adenocarcinoma
Interventions: DRUG: Firmagon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastroenterology Artificial INtelligence System for Detecting Colorectal Polyps (The GAIN Study)
Status: COMPLETED
Conditions: Colon Adenoma|Colon Polyp|Colon Lesion
Interventions: DEVICE: Computer-Assisted Detection (CADe) Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Care to Plan: a Tailored Resource for Family Members of Persons With Dementia
Status: COMPLETED
Conditions: Dementia|Alzheimer Disease|Memory Loss
Interventions: BEHAVIORAL: Care to Plan|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A 26-week Extension of the ZRHR-ERS-09-US Study Evaluating Biological and Functional Changes in Healthy Smokers After Switching to THS 2.2
Status: COMPLETED
Conditions: Smoking
Interventions: OTHER: THS 2.2|OTHER: CC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Examination of the Effects of Four Different Spices on Energy Metabolism
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: ginger|DIETARY_SUPPLEMENT: black pepper|DIETARY_SUPPLEMENT: horseradish|DIETARY_SUPPLEMENT: mustard|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phase IIb Trial of Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) (Ad5-nCoV) in Adults 18 Years of Age and Older.
Status: UNKNOWN
Conditions: Covid19
Interventions: BIOLOGICAL: Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) (Ad5-nCoV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Investigate the Pharmacokinetics (PK) and Pharmacodynamics (PD) of Idarucizumab in Chinese Healthy Male and Female Volunteers Who Had Taken Dabigatran Etexilate and Whose Plasma Concentrations of Dabigatran Were at or Close to Steady State
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Dabigatran etexilate|DRUG: Idarucizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Sodium Bicarbonate Ringer Injection
Status: NOT_YET_RECRUITING
Conditions: Ringer Bicarbonate|Elderly Abdominal Surgery|Safety|Effectiveness
Interventions: DRUG: sodium bicarbonate Ringer injection|DRUG: Lactated Ringer's solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of the Effectiveness of Vestibular Stimulation Treatment in the Depressive Phase of Bipolar Disorder
Status: RECRUITING
Conditions: Bipolar Disorder|Depression, Bipolar
Interventions: DEVICE: Vestibular stimulation|DEVICE: Sham vestibular stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Using Functional Progression to Guide the Treatment of Adolescent Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain|Spondylolysis|Spondylolisthesis
Interventions: OTHER: Standard Model of Care|OTHER: Alternative Model of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate Safety, Tolerability of LY4100511 (DC-853) in Healthy Asian and Non-Asian Participants
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: LY4100511 (DC-853)|DRUG: LY4100511 (DC-853)|DRUG: LY4100511 (DC-853)|DRUG: LY4100511 (DC-853)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study for the Transdermal Application of Teriparatide
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Subcutaneous Teriparatide|DRUG: Transdermal Teriparatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Tiotropium Bromide Inhalation Powder
Status: COMPLETED
Conditions: COPD
Interventions: COMBINATION_PRODUCT: Test Product (tiotropium bromide inhalation powder)|COMBINATION_PRODUCT: 18 mcg of Spiriva (Reference Product)|COMBINATION_PRODUCT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Induction of HO-1; a Therapeutic Approach to Reduce Ischaemia Reperfusion Injury (IRI) Following Deceased Donor Renal Transplantation
Status: COMPLETED
Conditions: Graft Failure|Ischemia-reperfusion Injury
Interventions: DRUG: Heme arginate (Normosang)|DRUG: 0.9% sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dual-dose Aprepitant to Reduce Postoperative Nausea and Vomiting After Laparoscopic Bariatric Surgery.
Status: RECRUITING
Conditions: Postoperative Nausea and Vomiting|Bariatric Surgery
Interventions: DRUG: Aprepitant 80 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Nasal Continuous Positive Airway Pressure on The Pharyngeal Swallow in Neonates
Status: COMPLETED
Conditions: Deglutition Disorders|Respiratory Distress Syndrome In Premature Infants|Respiratory Aspiration|Newborn, Premature
Interventions: DEVICE: NCPAP|DIETARY_SUPPLEMENT: Varibar® Thin Liquid Barium Sulfate for Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial for the Safety and Efficacy of Anti-CD7 CAR-T Cell Therapy for Patients With Relapsed or Refractory CD7 Positive Hematological Malignancy
Status: RECRUITING
Conditions: CD7+ Acute Leukemia|CD7+ Lymphoma
Interventions: BIOLOGICAL: anti-CD7 CAR-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Mature B-cell Lymphoma/Leukaemia
Status: COMPLETED
Conditions: B-Cell Lymphoma
Interventions: DRUG: half cyclophosphamide|DRUG: without COPADM3|DRUG: mini CYVE, without 3 maintenance courses|DRUG: LMB B|DRUG: LMB C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Patients
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|Chronic Bronchitis|Pulmonary Emphysema
Interventions: DRUG: Formoterol plus Placebo (Tiotropium)|DRUG: Formoterol plus Tiotropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COG-REAGENT: COGnitive tRaining in patiEnts With Amnestic Mild coGnitive impairmENT
Status: UNKNOWN
Conditions: Amnestic Mild Cognitive Impairment
Interventions: BEHAVIORAL: multi-domain internet-based adaptive training program|BEHAVIORAL: active-control program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Memory Aid by Intranasal Insulin in Diabetes (MemAID)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Regular Human Insulin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Folic Acid and/or Pentoxifylline on Patients With Chronic Kidney Disease
Status: ENROLLING_BY_INVITATION
Conditions: Chronic Kidney Diseases
Interventions: DRUG: combination of Pentoxifylline 400 MG and Folic Acid|DRUG: folic acid|DRUG: Pentoxifylline 400 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study in Healthy Male Subjects to Understand How Savolitinib When Taken With Midazolam Behaves Inside the Body
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Savolitinib|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Previously Treated KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer|KRAS G12C Lung Cancer
Interventions: DRUG: Divarasib|DRUG: Sotorasib|DRUG: Adagrasib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of One Evening Dose of 3 mg Eszopiclone on Next Day Driving Ability
Status: COMPLETED
Conditions: Primary Insomnia
Interventions: DRUG: Eszopiclone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating FXR-450 in Healthy Japanese Men
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: FXR-450|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Couple-based Interpersonal Psychotherapy on Postnatal Depression and Family Sense of Coherence
Status: COMPLETED
Conditions: Postnatal Depression
Interventions: BEHAVIORAL: Couple-based interpersonal psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Etoposide, Methylprednisolone, High-dose Cytarabine and Oxaliplatin (ESHAOx) for Refractory or Relapsed Hodgkin's Lymphoma (HL)
Status: UNKNOWN
Conditions: Hodgkin's Lymphoma
Interventions: DRUG: Oxaliplatin-based chemotherapy (ESHAOx)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Treatment Effect of an Anti-Infective Agent for Complicated Infections (0826-053)
Status: COMPLETED
Conditions: Sepsis
Interventions: DRUG: MK0826, ertapenem sodium / Duration of Treatment: 14 Days
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Armodafinil on Simulated Driving
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: armodafinil|DRUG: Placebo (for armodafinil)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PRidopidine's Outcome On Function in Huntington Disease, PROOF- HD
Status: ACTIVE_NOT_RECRUITING
Conditions: Huntington Disease
Interventions: DRUG: Pridopidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Alverine-simeticone and i3.1 Probiotic in IBS-D and IBS-M in Mexico
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: I31 probiotic|COMBINATION_PRODUCT: I31 probiotic combined to Alverine/Simethicone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Muscle Memory After Treatment With Anabolic Substance Clenbuterol and Resistance Training in Humans
Status: RECRUITING
Conditions: Skeletal Muscle Physiology
Interventions: DRUG: Clenbuterol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: HAL-MRE1 Subcutaneous Immunotherapy in Ragweed Allergic Patients First-in-human
Status: COMPLETED
Conditions: Rhinitis, Allergic|Rhinoconjunctivitis, Allergic
Interventions: BIOLOGICAL: HAL-MRE1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Outcomes With Robotic-Assisted Total Knee Arthroplasty
Status: ACTIVE_NOT_RECRUITING
Conditions: Arthroplasties, Knee Replacement
Interventions: DEVICE: Omnibotics Robotic-assisted Total Knee Arthroplasty with Apex UC|DEVICE: Omnibotics Robotic-assisted Total Knee Arthroplasty with Apex PS|DEVICE: Omnibotics Robotic-assisted Total Knee Arthroplasty with Apex Revision
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Sleep Hygiene Education and Lavender Oil Inhalation on Sleep Quality, Fatigue, Quality of Life
Status: COMPLETED
Conditions: Ostomy
Interventions: BEHAVIORAL: Lavender oil inhalation|BEHAVIORAL: Sleep hygiene education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Long Term Safety Study Of Lersivirine For The Treatment Of HIV-1 Infection In Subjects Who Have Completed Treatment With Lersivirine In Studies A5271015 And A5271022
Status: TERMINATED
Conditions: HIV-1
Interventions: DRUG: lersivirine|DRUG: lersivirine|DRUG: efavirenz|DRUG: lersivirine|DRUG: lersivirine|DRUG: etravirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of ART-123 in Subjects With Sepsis and Disseminated Intravascular Coagulation
Status: COMPLETED
Conditions: Sepsis|Disseminated Intravascular Coagulation
Interventions: DRUG: ART-123|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Uterine Artery Doppler Changes After Vaginal Administration of Isosorbide Mononitrate In Patients With URPL
Status: UNKNOWN
Conditions: Recurrent Pregnancy Loss
Interventions: DRUG: isosorbide mononitrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pragmatic Cluster Trial for Nursing Home Antipsychotic Prescribing
Status: COMPLETED
Conditions: Adverse Effect of Other Antipsychotics and Neuroleptics
Interventions: BEHAVIORAL: Audit + Feedback|BEHAVIORAL: Audit + Feedback + Educational Outreach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of AZD8871 in Healthy Subjects
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: AZD8871|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Home-based Transcranial Direct Current Stimulation for Treatment Resistant Depression
Status: RECRUITING
Conditions: Treatment Resistant Depression
Interventions: DEVICE: transcranial direct current stimulation|DEVICE: sham transcranial direct current stimulation|DEVICE: run-in sham transcranial direct current stimulation|BEHAVIORAL: Psychoeducation video|BEHAVIORAL: Tutorial video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cannabinoids and an Anti-inflammatory Diet for the Treatment of Neuropathic Pain After Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries|Neuropathic Pain
Interventions: OTHER: Placebo diet|OTHER: Anti-inflammatory diet|DRUG: Nabilone Capsules|OTHER: Placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Ascending Dose Study To Evaluate Safety And Pharmacokinetics Of Compound PF-06648671 In Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: PF-06648671|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Disitamab Vedotin in the Treatment With HER2- Expression, Subjects With Locally Advanced or Metastatic Castration-resistant Prostate Cancer
Status: RECRUITING
Conditions: Castration-resistant Prostate Cancer
Interventions: DRUG: Disitamab Vedotin Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcome of Patients Treated With IABP
Status: RECRUITING
Conditions: Acute Coronary Syndrome|Cardiogenic Shock|Coronary Artery Disease|Heart Failure|Left Ventricular Dysfunction|Low Cardiac Output Syndrome|Post-cardiac Surgery
Interventions: DEVICE: Intra Aortic Balloon Pump
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of the Combination Therapy of Rt-PA and Eptifibatide to Treat Acute Ischemic Stroke (CLEAR-FDR)
Status: COMPLETED
Conditions: Stroke|Brain Infarction
Interventions: DRUG: Eptifibatide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Eravacycline Compared With Ertapenem in Complicated Intra-abdominal Infections
Status: COMPLETED
Conditions: Complicated Intra-abdominal Infections
Interventions: DRUG: Eravacycline|DRUG: Ertapenem|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of AposTherapy® in Knee OA
Status: TERMINATED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Calibrated AposTherapy®|DEVICE: Non-Calibrated Sham Apos Therapy Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Pembrolizumab (MK-3475) Plus Neoadjuvant Chemotherapy Versus Perioperative Placebo Plus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle-invasive Bladder Cancer (MIBC) (MK-3475-866/KEYNOTE-866)
Status: ACTIVE_NOT_RECRUITING
Conditions: Bladder Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Gemcitabine|DRUG: Cisplatin|PROCEDURE: Surgery (radical cystectomy (RC) plus Pelvic Lymph Node Dissection [PLND])|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Radiation Therapy With or Without Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases
Status: COMPLETED
Conditions: Breast Cancer|Cognitive/Functional Effects|Lung Cancer|Metastatic Cancer|Prostate Cancer
Interventions: RADIATION: radiation therapy|RADIATION: stereotactic radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety of Three Intra-articular Injections of Ampion in the Knee of Adults With Osteoarthritis Pain
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: BIOLOGICAL: 4 mL injection of Ampion|DRUG: 4 mL injection of Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Efficacy and Safety of LUBT010 and Lucentis® in Patients With Neovascular AMD
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: Lucentis (ranibizumab)|DRUG: LUBT010 (proposed ranibizumab biosimilar)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Double-blind, Randomised Study of A3384 in BAM/BAD
Status: COMPLETED
Conditions: Bile Acid Malabsorption
Interventions: DRUG: A3384
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Wii-console Based Exercise on Shoulder Range of Motion for Post-mastectomy Lymphedema Patients
Status: RECRUITING
Conditions: Postmastectomy Lymphedema
Interventions: OTHER: traditional physical therapy session|OTHER: wii console based exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of ORL-1G (D-galactose) in Patients With Glycogen Storage Disease Type 14
Status: UNKNOWN
Conditions: Glycogen Storage Disease, Type 14
Interventions: DRUG: ORL-1G - D-galactose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smartphone Mindfulness Meditation for Patients With Rheumatic Diseases
Status: TERMINATED
Conditions: Inflammatory Arthritis|Scleroderma|Myositis|Sjogren's Syndrome|Systemic Lupus Erythematosus|Vasculitis
Interventions: BEHAVIORAL: Calm- Mindfulness Meditation smartphone application
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Low Dose Neuromuscular Blocker Usage on Laryngeal Mask Application
Status: UNKNOWN
Conditions: Anesthesia
Interventions: DRUG: Rocuronium Bromide|DRUG: Saline Solution|DRUG: Fentanyl|DRUG: Propofol|PROCEDURE: cystoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Safety and Efficacy of IQP- AK-102 in Reducing Body Weight
Status: COMPLETED
Conditions: Weight Loss
Interventions: DIETARY_SUPPLEMENT: IQP-AK-102|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Trial of a Treat and Extend Protocol Using Ranibizumab With and Without Laser Photocoagulation for Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Ranibizumab 0.3 mg intravitreal injection|DEVICE: Guided Laser Photocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BBI608 Plus Weekly Paclitaxel to Treat Gastric and Gastro-Esophageal Junction Cancer
Status: COMPLETED
Conditions: Gastric Cancer|Gastroesophageal Junction Cancer
Interventions: DRUG: BBI608|DRUG: Paclitaxel|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Different Lipid Emulsions in Acute Lung Injury Patients
Status: TERMINATED
Conditions: Parenteral Nutrition
Interventions: DRUG: Lipoplus 20%|DRUG: Lipofundin N 20%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Composite Class II Restorations With Two Different Matrix Bands
Status: UNKNOWN
Conditions: Class II Caries in Posterior Teeth
Interventions: DEVICE: Saddle contoured metal matrix, Pre-contoured self-adhesive matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MITO-2: A Study Comparing 2 Chemotherapy Regimens (Carboplatin/Liposomal Doxorubicin vs Carboplatin/Paclitaxel) in Patients With Ovarian Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: liposomal doxorubicin|DRUG: carboplatin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of Inhaled Carbon Monoxide in Kidney Transplant Patients
Status: WITHDRAWN
Conditions: Kidney Transplantation
Interventions: DRUG: Inhaled carbon monoxide|DRUG: Inhaled carbon monoxide|DRUG: Inhaled carbon monoxide|DRUG: Inhaled Carbon Monoxide|DRUG: Inhaled Carbon Monoxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: BfedBwell Optimization Pilot
Status: NOT_YET_RECRUITING
Conditions: Survivorship|Cancer
Interventions: BEHAVIORAL: BfedBwell - Core Curriculum|BEHAVIORAL: BfedBwell - 1:1 Counseling|BEHAVIORAL: BfedBwell - Behavioral Skills|BEHAVIORAL: BfedBwell - Group Support|BEHAVIORAL: Program delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Therapeutic Potential for Intranasal Levodopa in Parkinson's Disease -Off Reversal
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: COMBINATION_PRODUCT: Placebo|COMBINATION_PRODUCT: L-dopa 35 mg|COMBINATION_PRODUCT: L-dopa 70mg|COMBINATION_PRODUCT: L-dopa 140 mg|COMBINATION_PRODUCT: L-dopa 70mg/carbidopa 7mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rectal Tumor Resection Using the UNI-VEC Multichannel Transanal Access Device
Status: RECRUITING
Conditions: Rectal Polyp|Rectal Polyps|Rectal Lesion|Sessile Colonic Polyp|Pedunculated Colorectal Polyps
Interventions: DEVICE: Treatment of rectal lesions with UNI-VEC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wireless Nerve Stimulation Device To Enhance Recovery After Stroke
Status: RECRUITING
Conditions: Stroke|Chronic Stroke|Upper Extremity Paresis|Ischemic Stroke|Hemorrhagic Stroke
Interventions: DEVICE: Active Vagus Nerve Stimulation|DEVICE: Placebo Vagus Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Prenatal Steroids for Treatment of Congenital Cystic Adenomatoid Malformations (CCAM)
Status: TERMINATED
Conditions: Congenital Cystic Adenomatoid Malformation
Interventions: DRUG: Betamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vigorous- Versus Moderate-intensity Exercise to Reduce Liver Fat in Adults With Obesity and NAFLD
Status: RECRUITING
Conditions: Obesity|NAFLD
Interventions: OTHER: Usual Care Control Group|OTHER: Moderate-intensity Exercise Intervention|OTHER: Vigorous-intensity Exercise Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Assessment of Dual Site Left Ventricular Endocardial Pacing
Status: COMPLETED
Conditions: Atrial Fibrillation|Ventricular Tachycardia|Heart Failure
Interventions: PROCEDURE: Atrial Fibrillation/flutter (AF) or Ventricular Tachycardia (VT) ablation with multi-site pacing protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: ET-01 in Subjects With Lateral Canthal Lines
Status: COMPLETED
Conditions: Lateral Canthal Lines|Crow's Feet
Interventions: BIOLOGICAL: botulinum toxin, Type A|BIOLOGICAL: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TTX-030 Single Agent and in Combination With Immunotherapy or Chemotherapy for Patients With Advanced Cancers
Status: COMPLETED
Conditions: Solid Tumor|Lymphoma
Interventions: DRUG: TTX-030|DRUG: Pembrolizumab|DRUG: Gemcitabine|DRUG: nab paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Dexamethasone and Dexmedetomidine on the Analgesic Efficacy of Erector Spinae Plane Block
Status: COMPLETED
Conditions: Dexamethasone|Dexmedetomidine|Nerve Block
Interventions: DRUG: Dexamethasone and dexmedetomidine|DRUG: Dexmedetomidine|OTHER: Ultrasound-guided lumbar erector spinae plane block|OTHER: PCIA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gulhane Military Medical Academy Ethical Committee Exercise Program for Pregnant Women With Low Back and Pelvic Pain
Status: COMPLETED
Conditions: Pregnant|Pregnancy-related Low Back and Pelvic Pain
Interventions: BEHAVIORAL: exercise programme|BEHAVIORAL: standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Re-Entry MTC for Offenders With MICA Disorders
Status: COMPLETED
Conditions: Mental Disorders|Substance-Related Disorders
Interventions: BEHAVIORAL: Re-entry Modified Therapeutic Community (Re-entry MTC)|BEHAVIORAL: Parole Supervision and Case Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Digital Therapy for Diabetes Prevention Among Overweight Adults in Terengganu, Malaysia
Status: UNKNOWN
Conditions: Pre Diabetes|Overweight and Obesity
Interventions: BEHAVIORAL: MyDiPP (Malaysia Diabetes Prevention Program)|OTHER: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Beta 3 Agonists in Treatment of Non-neurogenic Voiding Dysfunction in Children
Status: UNKNOWN
Conditions: Voiding Disorders|Overactive Bladder
Interventions: DRUG: Beta3-Agonists, Adrenergic|DRUG: Anticholinergic drug, Solifenacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Platelet-dependent Thrombosis: a Placebo-controlled Trial of Antiplatelet Therapy (Clopidogrel)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Coronary Artery Disease
Interventions: DRUG: clopidogrel|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: This Study Will Evaluate the Efficacy, Safety, and Pharmacokinetics of the Port Delivery System With Ranibizumab in Participants With Diabetic Macular Edema Compared With Intravitreal Ranibizumab
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetic Macular Edema
Interventions: DRUG: PDS Implant Pre-Filled with 100 mg/mL Ranibizumab|DRUG: Intravitreal Ranibizumab 0.5 mg Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Rollover Study of ARRY-371797 in Patients With LMNA-Related Dilated Cardiomyopathy
Status: COMPLETED
Conditions: LMNA-Related Dilated Cardiomyopathy
Interventions: DRUG: ARRY-371797, p38 inhibitor, oral
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Novel Female Hygiene Device for Postcoital Discomfort
Status: UNKNOWN
Conditions: Vaginal Discharge|Dyspareunia|Female Sexual Dysfunction|Vaginitis|Bacterial Vaginoses
Interventions: DEVICE: Tampon-like device for absorption of sexual fluids
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Molecular Signatures of High-risk Oncogenic HPV and Study of Their Associations With the Presence of High-grade Lesions and/or Anal Cancer 10 Years After Inclusion in the ANRS IPERGAY Trial
Status: NOT_YET_RECRUITING
Conditions: HPV Infection|Anal Cancer
Interventions: PROCEDURE: High-resolution anoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Amager Project: Intervention After Suicide Attempt
Status: UNKNOWN
Conditions: Suicidal Behaviour|Repetition of Suicidal Behaviour
Interventions: BEHAVIORAL: OPAC (Outreach, Problem solving, Adherence, Continuity)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Conventional Lightwand Intubation Versus Video-laryngoscope Guided Lightwand Intubation in Simulated Cervical Spine-immobilized Patients
Status: COMPLETED
Conditions: General Anesthesia
Interventions: DEVICE: Video-laryngoscope guided lightwand|DEVICE: lightwand alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Study With Pyrotinib and Trastuzumab and Abraxane in Patients With HER2-enriched Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Pyrotinib, trastuzumab, paclitaxel-albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prolonged Isolated Thrombocytopenia After Allo-SCT : N-acetyl-L-cysteine (NAC) Versus Supportive Therapy
Status: TERMINATED
Conditions: Thrombocytopenia|Stem Cell Transplant Complications
Interventions: DRUG: N-acetyl-L-cysteine (NAC)|OTHER: supportive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PROState Pathway Embedded Comparative Trial
Status: COMPLETED
Conditions: Prostate Cancer|Non-metastatic Prostate Cancer|Metastatic Prostate Cancer|Prostate Adenocarcinoma|Metastatic Prostate Carcinoma in the Soft Tissue|Prostate Cancer Metastatic
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Internal Limiting Membrane Peeling in Retinal Detachment Surgery
Status: NOT_YET_RECRUITING
Conditions: Retinal Detachment|Proliferative Vitreoretinopathy
Interventions: PROCEDURE: Control group|PROCEDURE: Intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment of Two Daily Wear Monthly Replacement Soft Silicone Hydrogel Contact Lenses
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Lehfilcon A contact lenses|DEVICE: Comfilcon A contact lenses|DEVICE: CLEAR CARE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Low-dose Dexmedetomidine to Prevent Delirium in Liver Transplant Patients
Status: COMPLETED
Conditions: Liver Transplantation
Interventions: DRUG: Precedex|DRUG: placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Vitamin D Supplementation in Patients With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting|Vitamin D Deficiency
Interventions: DRUG: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of NV1FGF in Patients With Severe Peripheral Artery Occlusive Disease
Status: COMPLETED
Conditions: Peripheral Arterial Occlusive Disease
Interventions: DRUG: XRP0038 (NV1FGF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Potassium Bicarbonate on Bone and Several Physiological Systems During Immobilisation
Status: COMPLETED
Conditions: Bone Diseases, Metabolic|Acid-Base Imbalance|Muscular Atrophy|Sprains and Strains|Protein Metabolism|Body Weight Changes|Cardiovascular Abnormalities
Interventions: DIETARY_SUPPLEMENT: Potassium Bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vaccine Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma
Status: COMPLETED
Conditions: Giant Cell Glioblastoma|Glioblastoma|Gliosarcoma
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Malignant Glioma Tumor Lysate-Pulsed Autologous Dendritic Cell Vaccine|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Methylene Blue Photodynamic Therapy for Treatment of Deep Tissue Abscesses
Status: NOT_YET_RECRUITING
Conditions: Abscess
Interventions: DRUG: Methylene Blue|DRUG: Lipid Emulsion|DEVICE: Insertion of optical fiber|DEVICE: Laser Illumination (pre-defined dose)|DEVICE: Optical Spectroscopy Measurement|DEVICE: Laser Illumination (patient-specific dose)|PROCEDURE: Standard of care abscess drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extra Alirocumab in Addition to Statin Therapy in Asymptomatic Intracranial Atherosclerotic Stenosis (EAST-aICAS)
Status: NOT_YET_RECRUITING
Conditions: Intracranial Atherosclerosis|Atherosclerotic Plaque|Stenosis
Interventions: DRUG: Alirocumab|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation Therapy for Central Hypersomnia Without Cataplexy
Status: TERMINATED
Conditions: Hypersomnia
Interventions: DEVICE: Transcranial Direct Current Stimulation|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Predictive Clinical and Biological Parameters in Acute Leukemia, Myelodysplastic Syndromes and Myeloproliferative Disorders-HEMATO-BIO-IPC-2013-015
Status: UNKNOWN
Conditions: Acute Leukemia|Myelodysplastic Syndromes|Myeloproliferative Disorders
Interventions: OTHER: Blood sampling|OTHER: Bone marrow aspirate|OTHER: Skin biopsy|OTHER: Buccal swab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE