pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Intravitreal Aflibercept Injection (IAI) for Presumed Ocular Histoplasmosis Syndrome
Status: COMPLETED
Conditions: Choroidal Neovascularization|Presumed Ocular Histoplasmosis
Interventions: DRUG: EYLEA (Aflibercept) intravitreal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Blocking IL-4 With Pascolizumab in Patients Receiving Standard Therapy for Pulmonary Tuberculosis
Status: UNKNOWN
Conditions: Tuberculosis, Pulmonary
Interventions: DRUG: Pascolizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fortovase (Saquinavir) Given With Low-Dose Ritonavir, Zidovudine, and Lamivudine to HIV-Positive Pregnant Women During and After Pregnancy and to Their Newborns
Status: COMPLETED
Conditions: HIV Infections|Pregnancy
Interventions: DRUG: Ritonavir|DRUG: Saquinavir|DRUG: Lamivudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy and Safety Profile of Zabofloxacin Tablet 400mg and Moxifloxacin Tablet 400mg
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Zabofloxacin|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Two Surgical Techniques for Soft Tissue Healing and Implant Stability of Cochlear BI300 Implants.
Status: COMPLETED
Conditions: Hearing Loss, Conductive
Interventions: PROCEDURE: BAHA implant insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of PAP on Afib Recurrence Risk After Catheter Ablation in OSA Patients
Status: WITHDRAWN
Conditions: Obstructive Sleep Apnea|Atrial Fibrillation
Interventions: PROCEDURE: Cardiac Ablation for Atrial Fibrillation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Cytoprotective Effect and Clinical Outcome of Perioperative Proesterone in Brain Tumors
Status: UNKNOWN
Conditions: Diffuse Traumatic Cerebral Edema
Interventions: DRUG: Progesteron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Dapansutrile for Treatment of Moderate COVID-19 Symptoms and Evidence of Early Cytokine Release Syndrome
Status: TERMINATED
Conditions: Covid19|Cytokine Release Syndrome
Interventions: DRUG: dapansutrile capsules|DRUG: placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Collection of Tumor Biopsy and Plasma Samples From Cancer Patients Treated With Molecular Targeted Therapies or Immunotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer
Interventions: DRUG: Immunotherapeutic Agent|DRUG: Molecular Target
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TLK286 (Telcyta) vs. Doxil/Caelyx or Hycamtin in Platinum Refractory or Resistant Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Neoplasms
Interventions: DRUG: TLK286 HCl for injection|DRUG: topotecan hydrochloride for injection|DRUG: doxorubicin HCl liposome injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Interaction Study Between Odalasvir, Given as a Single Agent or in Combination With Simeprevir, and Dabigatran Etexilate Mesylate in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Dabigatran etexilate mesylate|DRUG: Odalasvir (ODV)|DRUG: Simeprevir (SMV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of the Interest of Hyaluronic Acid in the Preservation of Sexual Function During Prostate Curietherapies
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DEVICE: Hyaluronic acid arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Targeting Leukemic Stem Cell Expressing the IL-1RAP Protein in Chronic Myelogenous Leukemia (CML)
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia
Interventions: OTHER: biological samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Polyphenol-rich Dark Chocolate on Insulin Sensitivity in Normal Weight and Overweight Adults
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: OTHER: Polyphenol-rich Dark chocolate|OTHER: Placebo Dark chocolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Evaluation of Nano Hydroxyapatite Reinforced Glass Ionomer in Treatment of Root Caries in Geriatric Patients
Status: UNKNOWN
Conditions: Dental Restoration Failure
Interventions: DRUG: Conventional glass ionomer|DRUG: Nano hydroxyapatite reinforced glass ionomer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CleanUP IPF for the Pulmonary Trials Cooperative
Status: TERMINATED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Antimicrobial therapy: Co-trimoxazole or Doxycycline|OTHER: No Intervention: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First in Human Study in Subjects With Obesity, But Otherwise Healthy
Status: RECRUITING
Conditions: Obesity
Interventions: DRUG: DA-1726|DRUG: Placebo to DA-1726
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: YH001 Plus Envafolimab With or Without Doxorubicin in Patients With Advanced or Metastatic Sarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Sarcoma|Metastatic Sarcoma|Soft Tissue Sarcoma
Interventions: DRUG: YH001|DRUG: Envafolimab|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Adverse Events and Change in Disease Activity of Subcutaneous (SC) Epcoritamab in Combination With Oral and Intravenous Anti-Neoplastic Agents in Adult Participants With Non-Hodgkin Lymphoma
Status: RECRUITING
Conditions: Non-Hodgkin Lymphoma
Interventions: DRUG: Epcoritamab|DRUG: Lenalidomide|DRUG: Ibrutinib|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Doxorubicin Hydrochloride [HCl]|DRUG: Prednisone|DRUG: Polatuzumab Vedotin|DRUG: Venetoclax|DRUG: CC-99282
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Richmond Agitation Sedation Scale According to Alveolar Concentration of Sevoflurane During a Sedation With Sevoflurane in ICU Patients
Status: COMPLETED
Conditions: Requiring Sedation by Sevoflurane in ICU|Adult Patients|Patients Covered by French Health Care System|Patients Who Have Given Their Consent
Interventions: DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arterial Spin Labeling Blood Flow MRI for Evaluation of Response to Antiangiogenic and Targeted Therapies of Renal Cell Carcinoma (RCC)
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: OTHER: Arterial Spin Labeling Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Effectiveness and Safety of Paliperidone Extended-release (ER) Tablets in the Prevention of Recurrence in Adult Patients With Schizophrenia.
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Paliperidone ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Vorinostat and Bortezomib as Third-line Treatment in Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non Small Cell Lung
Interventions: DRUG: vorinostat|DRUG: bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NEUROENDOCRINE REGULATION OF BONE-FAT CROSSTALK IN OBESITY
Status: NOT_YET_RECRUITING
Conditions: Obesity; Endocrine|Pituitary Dysfunction|Bone Health
Interventions: DIAGNOSTIC_TEST: Dexa or Biompedance analysis with clinical and biochemical evaluations
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Recovery of Cardiovascular Function With Epidural Stimulation After Human Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: DEVICE: 5-6-5 Specify electrode|DEVICE: Restore Advance Pulse Generator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Meat and Whey Protein Supplementation in Athletes
Status: COMPLETED
Conditions: Dietary Modification
Interventions: DIETARY_SUPPLEMENT: Meat Protein|DIETARY_SUPPLEMENT: Whey protein|DIETARY_SUPPLEMENT: Carbohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Erector Spinae Plane Block in Breast Surgery
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Local anesthetic|DRUG: Hyaluronidase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Continuation Study Using Sunitinib Malate For Patients Leaving Treatment On A Previous Sunitinib Study.
Status: COMPLETED
Conditions: Metastatic Breast Cancer|Advanced Breast Cancer|Metastatic Castration Resistant Prostate Cancer|Metastatic Renal Cell Cancer|Non-Small Cell Lung Cancer|Thyroid Cancer|Advanced/Metastatic Non-Small Cell Lung Cancer|Advanced Gastric Cancer|Gastrointestinal Stromal Tumor|Hepatocellular Carcinoma|Pancreatic Islet Cell Carcinoma|Pancreatic Neuroendocrine Tumor
Interventions: DRUG: sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)
Status: RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Ann Arbor Stage III Non-Hodgkin Lymphoma|Ann Arbor Stage IV Non-Hodgkin Lymphoma|Histiocytic Sarcoma|Juvenile Xanthogranuloma|Langerhans Cell Histiocytosis|Malignant Glioma|Recurrent Childhood Rhabdomyosarcoma|Recurrent Ependymoma|Recurrent Ewing Sarcoma|Recurrent Glioma|Recurrent Hepatoblastoma|Recurrent Langerhans Cell Histiocytosis|Recurrent Malignant Germ Cell Tumor|Recurrent Malignant Solid Neoplasm|Recurrent Medulloblastoma|Recurrent Neuroblastoma|Recurrent Non-Hodgkin Lymphoma|Recurrent Osteosarcoma|Recurrent Peripheral Primitive Neuroectodermal Tumor|Recurrent Primary Central Nervous System Neoplasm|Recurrent Rhabdoid Tumor|Recurrent Soft Tissue Sarcoma|Refractory Ewing Sarcoma|Refractory Glioma|Refractory Hepatoblastoma|Refractory Langerhans Cell Histiocytosis|Refractory Malignant Germ Cell Tumor|Refractory Malignant Solid Neoplasm|Refractory Medulloblastoma|Refractory Neuroblastoma|Refractory Non-Hodgkin Lymphoma|Refractory Osteosarcoma|Refractory Peripheral Primitive Neuroectodermal Tumor|Refractory Primary Central Nervous System Neoplasm|Refractory Rhabdoid Tumor|Refractory Rhabdomyosarcoma|Rhabdoid Tumor|Stage III Osteosarcoma AJCC v7|Stage III Soft Tissue Sarcoma AJCC v7|Stage IV Osteosarcoma AJCC v7|Stage IV Soft Tissue Sarcoma AJCC v7|Stage IVA Osteosarcoma AJCC v7|Stage IVB Osteosarcoma AJCC v7|Wilms Tumor
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration and Biopsy|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|DRUG: Ensartinib|DRUG: Erdafitinib|OTHER: Laboratory Biomarker Analysis|DRUG: Larotrectinib Sulfate|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Mutation Carrier Screening|DRUG: Olaparib|DRUG: Palbociclib|OTHER: Pharmacological Study|PROCEDURE: Positron Emission Tomography|PROCEDURE: Radionuclide Imaging|DRUG: Samotolisib|DRUG: Selpercatinib|DRUG: Selumetinib Sulfate|DRUG: Tazemetostat|DRUG: Tipifarnib|DRUG: Ulixertinib|DRUG: Vemurafenib|PROCEDURE: X-Ray Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: PoNS® Therapy for Gait and Balance Deficits in Chronic Stroke Survivors: A Single-Arm Study
Status: RECRUITING
Conditions: Chronic Stroke Survivors
Interventions: DEVICE: Portable Neuromodulation Stimulator (PoNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin, Nelfinavir, and Bortezomib in Treating Patients With Relapsed and/or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: DRUG: Bortezomib|DRUG: Metformin Hydrochloride|DRUG: Nelfinavir Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurostimulation to Improve NOWS Outcomes
Status: RECRUITING
Conditions: Neonatal Opioid Withdrawal Syndrome|Neonatal Abstinence Syndrome
Interventions: DEVICE: Sparrow Fledging Therapy System|DEVICE: Sham Sparrow Fledging Therapy System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PrEPTECH Phase 2 Study of a PrEP Telehealth Intervention
Status: COMPLETED
Conditions: Pre-Exposure Prophylaxis|HIV|Telemedicine
Interventions: OTHER: PrEPTECH website|OTHER: Online PrEP resource list
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pre-hospital Administration of Fibrinogen in Trauma-Induced Coagulopathy
Status: NOT_YET_RECRUITING
Conditions: Trauma Induced Coagulopathy
Interventions: DRUG: Fibrinogen concentrate|DRUG: Standard trauma care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Efficacy of BC 007 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: BC 007|DRUG: NaCl 0.9 %
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Application of Target Controlled Infusion of Etomidate Combined With Propofol in the Maintenance of Anesthesia During Brain Surgeries
Status: UNKNOWN
Conditions: Target Controlled Infusion|General Anesthesia
Interventions: DRUG: propofol|DRUG: etomidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diabetes Prevention Among Post-partum Women With History of Gestational Diabetes
Status: COMPLETED
Conditions: Gestational Diabetes Mellitus|Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Life Style Counseling (Star-Mama)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate EP547 in Subjects With Cholestatic Pruritus Due to Primary Biliary Cholangitis or Primary Sclerosing Cholangitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Pruritus
Interventions: DRUG: EP547|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety and Efficacy of Elsubrutinib and Upadacitinib Given Alone or in Combination in Participants With Moderately to Severely Active Systemic Lupus Erythematosus (SLE)
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus (SLE)
Interventions: DRUG: Elsubrutinib|DRUG: Placebo for elsubrutinib|DRUG: Upadacitinib|DRUG: Placebo for upadacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety, Pharmacokinetic Profile and Efficacy of Raltegravir in HIV-infected Patients at Least 60 Years of Age
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Raltegravir|DRUG: Tenofovir|DRUG: Emtricitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-field MRI for Breast Cancer Screening
Status: ENROLLING_BY_INVITATION
Conditions: Breast Benign|Malignant Neoplasm of Breast|Breast Malignant Tumor
Interventions: DEVICE: Magnetic Resonance Imaging (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Violet Light for the Suppression of Myopia
Status: RECRUITING
Conditions: Myopia|Phototherapy
Interventions: DEVICE: Violet Light Lamp|DEVICE: White Light Lamp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Unripe Bokbunja Extract on Improvement of Blood Cholesterol
Status: COMPLETED
Conditions: Blood Cholesterol
Interventions: DIETARY_SUPPLEMENT: unripe Bokbunja Extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of the Extract of Carica Papaya as an Inhibitor of Streptococcus Mutans
Status: COMPLETED
Conditions: Streptococcus, Other Specified Group|Dental Plaque
Interventions: OTHER: CARICA PAPAYA MOUTHWASH|OTHER: CHLORHEXIDINE MOUTHWASH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Early Feasibility Study of the Cardiovalve System for Tricuspid Regurgitation
Status: WITHDRAWN
Conditions: Tricuspid Regurgitation
Interventions: DEVICE: Cardiovalve Transfemoral Tricuspid Valve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety Assessment of VX-121/Tezacaftor/Deutivacaftor in Participants With Moderate Hepatic Impairment
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: VX-121/TEZ/D-IVA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess the Safety and Bioeffect of REGN1033 (SAR391786)
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: REGN1033 (SAR391786)|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Entacapone,Levodopa and Carbidopa Tablets in the Postprandial State in Healthy Chinese Subjects
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DRUG: Test (T) Entacapone,Levodopa and Carbidopa Tablets (II)|DRUG: Reference (R) Entacapone,Levodopa and Carbidopa Tablets (II)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aggressive Thoracic Radiotherapy for Stage Ⅳ Non Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung|Stage IV|Thoracic Radiotherapy
Interventions: RADIATION: Aggressive Thoracic Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Safety of a Drug Called Osocimab at Low and High Doses in Adult Patients With Kidney Failure Requiring Regular Hemodialysis
Status: COMPLETED
Conditions: End-stage Renal Disease|Prevention of Thromboembolic Events|Hemodialysis|Hemodiafiltration
Interventions: DRUG: BAY1213790 (Osocimab)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy of CCRT With Paclitaxel as Adjuvant Therapy to Post-Operative Advanced Endometrial Cancer Patients
Status: UNKNOWN
Conditions: Endometrial Cancer
Interventions: DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Efficacy and Pharmacokinetic Profile of K-877-ER Compared to K-877-IR
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: K-877-ER (Dose A)|DRUG: K-877-ER (Dose B)|DRUG: K-877-IR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Nordic Walking in Patients With Asthma.
Status: ENROLLING_BY_INVITATION
Conditions: Asthma
Interventions: PROCEDURE: Nordic walking program|PROCEDURE: Educational sessions and usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Physiology of Nasal High Flow Therapy
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DEVICE: NHF therapy|OTHER: Long term Oxygen Therapy (LOT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Action Observation Treatment on Motor Function in Upper Limb of Patients With Chronic Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: COMBINATION_PRODUCT: Action observation treatment|COMBINATION_PRODUCT: conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risk Stratification and New Early Prevention and Treatment Strategies for Patients With Cardiomyopathy (STRENGTH）
Status: RECRUITING
Conditions: Cardiomyopathies
Interventions: BIOLOGICAL: Diagnosis of HCM|BIOLOGICAL: Diagnosis of DCM|BIOLOGICAL: Diagnosis of ARVC|BIOLOGICAL: Diagnosis of NDLVC|BIOLOGICAL: Diagnosis of RCM|BIOLOGICAL: Diagnosis of LVNC
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Medium and Long Term Follow-up of COVID-19 Infected Patients: Research and Characterization of Pulmonary Sequelae
Status: ACTIVE_NOT_RECRUITING
Conditions: Sars-CoV2
Interventions: DIAGNOSTIC_TEST: Pulmonary function testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of AERAS 422 in Healthy Adults
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: AERAS-422|DRUG: BCG Tice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Recombinant Human Thyroid Stimulating Hormone for Adjuvant Diagnosis in Patients With Locally Advanced/Metastatic Differentiated Thyroid Cancer
Status: RECRUITING
Conditions: Recombinant Human Thyroid Stimulating Hormone
Interventions: DRUG: Recombinant Human Thyroid Stimulating Hormone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dutasteride With Tolterodine ER or Placebo to Treat Lower Urinary Tract Symptoms (LUTS)
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia (BPH)
Interventions: DRUG: Tolterodine ER 4mg|DRUG: Placebo|DRUG: Pre-randomization Dutasteride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aripiprazole for the Treatment of Patients With Agitation Associated With Dementia of the Alzheimer's Type
Status: TERMINATED
Conditions: Agitation Associated With Dementia of the Alzheimer's Type
Interventions: DRUG: 2 mg/day|DRUG: 3 mg/day|DRUG: 6 mg/day|DRUG: Placebo (0 mg/day)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nebulized Budesonide Combined With Systemic Corticosteroid in Acute Severe Asthma
Status: UNKNOWN
Conditions: Acute Asthma
Interventions: DRUG: Budesonide|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn How Well a Higher Amount of Aflibercept Given as an Injection Into the Eye Works and How Safe it is in People With Reduced Vision Due to Swelling in the Macula, Central Part of the Retina Caused by a Blocked Vein in the Retina (Macula Edema Secondary to Retinal Vein Occlusion)
Status: RECRUITING
Conditions: Macular Edema Secondary to Retinal Vein Occlusion
Interventions: DRUG: Aflibercept, VEGF Trap-Eye(Eylea, BAY86-5321)_higher dose|DRUG: Aflibercept, VEGF Trap-Eye(Eylea, BAY86-5321)_2 mg|DRUG: Sham|DIAGNOSTIC_TEST: Fluorescein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Relationship Between Dose-concentration-effect of Delta-9-tetrahydrocannabinol (THC) and the Ability to Drive in Chronic or Occasional Cannabis Users
Status: COMPLETED
Conditions: Occasional (1-2 Joints Per Week) and Chronic (1-2 Joints Per Day) Cannabis Users
Interventions: DRUG: Cannabis (THC) in cigarettes of 30mg, 10mg and placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dentin Bridge Formation After Indirect Pulp Capping With Bioactive Glass Incorporated in Resin Composite and Its Adhesive in Comparison With Light Cured Calcium Hydroxide
Status: COMPLETED
Conditions: Pulp Disease, Dental|Dental Caries
Interventions: OTHER: Bioactive Glass|OTHER: Light cured calcium hydroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Narrow Band Versus Conventional Endoscopic Imaging for Screening Colonoscopy
Status: COMPLETED
Conditions: Adenoma
Interventions: DEVICE: Olympus NBI colonoscope 180 HDTV narrow band imaging (diagnostic test)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of BWC0977 in Healthy Adult Volunteers
Status: TERMINATED
Conditions: Infectious Diseases|Bacterial Infections
Interventions: DRUG: BWC0977|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Versus Combined Oral and Intravenous Antimicrobial Prophylaxis for the Prevention of Surgical Site Infection in Elective Colorectal Surgery
Status: COMPLETED
Conditions: Elective Colorectal Surgery
Interventions: DRUG: ornidazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase III, Multicentre, Double-Blind, Placebo-Controlled Withdrawal Study in Patients With Hyperphosphatemia
Status: COMPLETED
Conditions: Chronic Kidney Disease|Hyperphosphatemia
Interventions: DRUG: MCI-196 (Colestilan(INN), Colestimide(JAN), CHOLEBINE®)|DRUG: Placebo|DRUG: Another phosphate binder (Sevelamer)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Asenapine in Elderly Subjects With Psychosis (A7501021)(P05717)
Status: COMPLETED
Conditions: Psychosis
Interventions: DRUG: Asenapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Vildagliptin Versus Placebo in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Vildagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy and Safety of AG-348 in Not Regularly Transfused Adult Participants With Pyruvate Kinase Deficiency (PKD)
Status: COMPLETED
Conditions: Pyruvate Kinase Deficiency|Anemia, Hemolytic
Interventions: DRUG: Placebo|DRUG: AG-348
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Kinetics of COVID-19 Antibodies for 24 Months in Patients With Confirmed SARS-CoV-2 Infection
Status: COMPLETED
Conditions: Covid19|SARS-CoV-2
Interventions: OTHER: Sampling by venipuncture (and eventually by nasopharyngeal swab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Electroacupuncture in Reducing the Dose of Analgesic in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
Status: COMPLETED
Conditions: Coronary Disease
Interventions: DEVICE: TEAS (transcutaneous electric acupoint stimulation)|DEVICE: TEAS|DEVICE: TEAS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tocotrienols and Bone Health of Postmenopausal Women
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Low tocotrienols group|DRUG: High tocotrienols group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial Comparing Treatment Strategies in Dupuytren's Contracture
Status: ACTIVE_NOT_RECRUITING
Conditions: Dupuytren Contracture
Interventions: PROCEDURE: Percutaneous needle fasciotomy (PNF)|DRUG: Collagenase Clostridium Histolyticum (CCH) 2.9 MG/ML [Xiaflex]|PROCEDURE: Limited fasciectomy (LF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a Personalized Polyepitope DNA Vaccine Strategy in Breast Cancer Patients With Persistent Triple-Negative Disease Following Neoadjuvant Chemotherapy
Status: COMPLETED
Conditions: Triple Negative Breast Cancer|Triple-Negative Breast Cancer|Triple Negative Breast Neoplasms
Interventions: BIOLOGICAL: Personalized polyepitope DNA vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Safety and Feasibility of Transcutaneous Spinal Cord Stimulation Following Traumatic and Non-Traumatic Spinal Cord Injury: A Pilot Study
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Stimulation|Electric Stimulation Therapy|Traumatic Spinal Cord Injury|Cervical Myelopathy
Interventions: DEVICE: Transcutaneous Spinal Cord Stimulation (Tc-SCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Different Doses of Tai Chi Chuan on Cognitive Function in Persons With Mild Cognitive Impairment
Status: NOT_YET_RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Lower frequency, shorter period of Tai Chi Chuan|BEHAVIORAL: Higher frequency, shorter period of Tai Chi Chuan|BEHAVIORAL: Lower frequency, longer period of Tai Chi Chuan|BEHAVIORAL: Higher frequency, longer period of Tai Chi Chuan|BEHAVIORAL: Standard Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Components of Chlorhexidine Gluconate Dressing
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: CHG Catheter Dressing Patch|DEVICE: Biopatch|DEVICE: Tegaderm CHG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer
Status: RECRUITING
Conditions: Non-Muscle Invasive Bladder Cancer
Interventions: COMBINATION_PRODUCT: TAR-210|DRUG: Gemcitabine|DRUG: MMC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Intravenous Lidocaine on Transperitoneal Laparoscopic Urological Surgery
Status: COMPLETED
Conditions: Pain|Fatigue
Interventions: DRUG: lidocaine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Neurofeedback and Transcranial Pulse Stimulation on Attention
Status: RECRUITING
Conditions: Attention Difficulties
Interventions: DEVICE: Transcranial pulse stimulation (TPS)|DEVICE: Neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Lung Cancer Detection in Patients With Sputum Cytology and Autofluorescence Bronchoscopy in People at High Risk of Lung Cancer
Status: COMPLETED
Conditions: Lung Neoplasms
Interventions: PROCEDURE: Bronchoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect Custom Foot Orthotics on Comfort, Kinetics and Kinematics
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Custom Foot Orthotics EVA|DEVICE: Original Liner|DEVICE: Custom Foot Orthotics PU|DEVICE: Custom Hybrid Foot Orthotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of a Healthy Food Voucher on Blood Glucose Control in People With Type 2 Diabetes or Prediabetes
Status: RECRUITING
Conditions: Diabete Type 2
Interventions: BEHAVIORAL: Food voucher
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Precision Cell Immunotherapy Combined With Chemotherapy in Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Precision Cell Immunotherapy|Chemotherapy|Advanced Gastric Cancer
Interventions: DRUG: Chemotherapy|BIOLOGICAL: Precision Cell Immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Raltitrexed Plus Docetaxel Versus Docetaxel as Second-line Chemotherapy in Subjects With Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: Raltitrexed plus Docetaxel|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Amino Acid Absorption After Adding a Probiotic to an Acute Protein Feeding
Status: COMPLETED
Conditions: Amino Acid Absorption
Interventions: DIETARY_SUPPLEMENT: Milk protein + GBI-30|DIETARY_SUPPLEMENT: Milk protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: L19TNFα in Combination With Doxorubicin in Patients With Advanced Solid Tumours
Status: COMPLETED
Conditions: Advanced Solid Tumors Amenable to Anthracycline Therapy|Sarcoma, Breast Cancer, Lung Carcinomas, and Gynecological Cancer Amenable to Anthracycline Therapy
Interventions: DRUG: L19TNFα|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study Evaluating AMG 232 in Advanced Solid Tumors or Multiple Myeloma
Status: COMPLETED
Conditions: Advanced Malignancy|Advanced Solid Tumors|Cancer|Oncology|Oncology Patients|Tumors|Glioblastoma|Multiple Myeloma
Interventions: DRUG: AMG 232
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postpartum Video Education in High Risk Populations
Status: RECRUITING
Conditions: Postpartum Hemorrhage|Postpartum Depression|Postpartum Sepsis|Postpartum Preeclampsia|Patient Empowerment|Patient Education|Postpartum Care
Interventions: OTHER: Video Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: User Site Testing Study to Evaluate Usability of the Q300™ Device Under "Real-life Conditions" in a Reproductive Laboratory Environment Use
Status: RECRUITING
Conditions: to Aid in Sperm Selection for ICSI
Interventions: DEVICE: Q300 QART Medical
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transanal Total Mesorectal Excision Versus Robotic Total Mesorectal Excision
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: PROCEDURE: Transanal Total Mesorectal Excision|PROCEDURE: Robotic Total Mesorectal Excision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
Status: RECRUITING
Conditions: Heart Diseases|Coronary Artery Disease|Coronary Artery Bypass Grafting
Interventions: PROCEDURE: Single arterial graft|PROCEDURE: Multiple arterial grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-emptive Dexamethasone in Hip Arthroplasty
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Normal saline|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sperm Preparation Prior to Intrauterine Insemination Study
Status: RECRUITING
Conditions: Infertility|Infertility Secondary|Infertility Unexplained|Anovulation|Fertility Disorders|Reproductive Issues
Interventions: DEVICE: Zymot Multi sperm separation device|OTHER: Density gradient centrifugation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Sapropterin on Cognitive Abilities in Young Adults With Phenylketonuria
Status: TERMINATED
Conditions: Phenylketonuria
Interventions: DRUG: Sapropterin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a Group B Streptococcus Vaccine in Non Pregnant and Pregnant Women 18-40 Years of Age
Status: COMPLETED
Conditions: Streptococcal Infections
Interventions: BIOLOGICAL: Group B Streptococcus Trivalent Vaccine - 20/20/20 μg|OTHER: Saline solution|BIOLOGICAL: Group B Streptococcus Trivalent Vaccine - 0.5/0.5/0.5 μg|BIOLOGICAL: Group B Streptococcus Trivalent Vaccine - 2.5/2.5/2.5 μg|BIOLOGICAL: Group B Streptococcus Trivalent Vaccine - 5/5/5 μg|OTHER: saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Glutamine on Gastric Emptying
Status: COMPLETED
Conditions: Starvation
Interventions: DIETARY_SUPPLEMENT: Nutricia PreOp nutritional supplement|DIETARY_SUPPLEMENT: Lipid|DIETARY_SUPPLEMENT: Glutamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Peritoneal Closure and Retroperitoneal Drainage on Patients Who Underwent Laparotomic Retroperitoneal Lymph Node Dissection
Status: COMPLETED
Conditions: Lymphocele|Gynecologic Cancer
Interventions: PROCEDURE: Peritoneal closure|PROCEDURE: Retroperitoneal drainage
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Open Label, Dose Escalating Study to Evaluate the Safety and Tolerability of Ascending Intravenous (i.v.) Doses of Catumaxomab in Epithelial Cancer Patients
Status: TERMINATED
Conditions: Epithelial Cancer Patients
Interventions: DRUG: catumaxomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Anti-Human Immunodeficiency Virus (HIV) & Anti-inflammatory Effect of Chloroquine
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: chloroquine phosphate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Combined Surgical and Medical Approach in Mild Sleep Apnea
Status: UNKNOWN
Conditions: Sleep Apnea
Interventions: DRUG: acetazolamide|DRUG: placebo|PROCEDURE: uvulopalatopharygoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Text Neck Syndrome and Hand Grip Force in Smart Phone Addiction Among Students of Jazan University
Status: COMPLETED
Conditions: Pain, Back|Neck Pain|Postural; Strain|Myofascial Pain Syndrome
Interventions: DIAGNOSTIC_TEST: Pain Pressure Threshold|DIAGNOSTIC_TEST: Hand Grip Force
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Two Types of Biopsy Needles for EUS-FNB in Solid Pancreatobiliary Mass Lesions
Status: COMPLETED
Conditions: Pancreatic Neoplasms
Interventions: DEVICE: Fine needle biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Rofecoxib in the Treatment of Post-Operative Pain After Total Knee Joint Replacement (0966-259)
Status: TERMINATED
Conditions: Pain
Interventions: DRUG: MK0966; rofecoxib|DRUG: Comparator: diclofenac 2x 75 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Extension of Prior TERMS Study to Treat Relapsing Forms of Multiple Sclerosis
Status: TERMINATED
Conditions: Multiple Sclerosis, Relapsing-Remitting|Clinically Isolated Syndrome
Interventions: BIOLOGICAL: Tovaxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Escitalopram in Pediatric Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Escitalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Acute Glycemic Response to Different Strategies of Breaking Up Sedentary Time
Status: COMPLETED
Conditions: Pre Diabetes|Postprandial Hyperglycemia
Interventions: BEHAVIORAL: CS: Continuous sitting|BEHAVIORAL: HFLD: HIgh frequency, low duration standing breaks|BEHAVIORAL: LFHD: Low frequency, high duration standing breaks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Adding Desmopressin to Tamsulosin for Treatment of BPH
Status: RECRUITING
Conditions: Nocturnal Polyurea in Patients With BPH
Interventions: DRUG: Desmopressin Acetate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnosis of Nodules ≤2 cm Based on US and CEUS Compared With Current Clinical Procedure
Status: RECRUITING
Conditions: Liver Cancer|Liver Cirrhosis
Interventions: DIAGNOSTIC_TEST: Immediate CEUS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC