pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparison of Hemi-shoulder Arthroplasty and PHILOS in Treating Three or Four-part Fractures of Proximal Humerus
Status: UNKNOWN
Conditions: Humeral Fracture, Proximal
Interventions: PROCEDURE: Hemi-shoulder Arthroplasty|PROCEDURE: PHILOS Plate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Study Device Attributes by Investigating Errors Made in Use, Ease of Use and Preference Among Different Inhalers in Subjects With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DEVICE: ELLIPTA|DEVICE: DISKUS/ACCUHALER|DEVICE: MDI|DEVICE: TURBUHALER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Study of FOND Versus FOND+O for the Prevention of CINV in Hematology Patients Receiving Highly Emetogenic Chemotherapy Regimens
Status: COMPLETED
Conditions: Complications of Bone Marrow Transplant|Hematologic Neoplasms
Interventions: DRUG: Olanzapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mesh Augmented Reinforcement of Abdominal Wall Suture Line to Limit the Rate of Incisional Hernia Occurrence
Status: RECRUITING
Conditions: Incisional Hernia|Incisional Hernia of Midline of Abdomen|Midline Laparotomy
Interventions: DEVICE: Self-Gripping Resorbable Mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase I Multicenter Trial Combining Nivolumab, Ipilimumab and Hypo-fractionated Radiotherapy for Pretreated Advanced Stage Non-small Cell Lung Cancer Patients
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: RADIATION: hypofractionated radiotherapy|DRUG: nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EphB4-HSA Fusion Protein and Cytarabine /or Liposomal Vincristine in Patients With Recurrent or Refractory Acute Leukemia
Status: TERMINATED
Conditions: Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Blasts 5 Percent or More of Bone Marrow Nucleated Cells|Myelodysplastic/Myeloproliferative Neoplasm|Philadelphia Chromosome Positive|Recurrent Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Refractory Acute Lymphoblastic Leukemia|Refractory Acute Myeloid Leukemia|Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Secondary Acute Myeloid Leukemia|T Acute Lymphoblastic Leukemia
Interventions: DRUG: Cytarabine|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Recombinant EphB4-HSA Fusion Protein|DRUG: Vincristine Liposomal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Autologous Ex Vivo Activated NK Cell Infusion in the Treatment of Metastatic Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Metastatic Nasopharyngeal
Interventions: DRUG: Interleukin, NK cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Early Oral Triple Viable Bifidobacterium Intestinal Flora in Preterm
Status: COMPLETED
Conditions: Disorder of Stomach Function and Feeding Problems in Newborn|Feeding and Eating Disorders of Childhood
Interventions: DRUG: a control group|DRUG: a probiotic-supplemented group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SAPHIR : Assessment of Predictive Factors for Persistence of Treatment After Initiation of Adalimumab With a Biosimilar (Adalimumab Fresenius KaBI or Substitution of Reference Adalimumab With the Fresenius Kabi Adalimumab Biosimilar in Patients With Chronic Inflammatory Diseases
Status: RECRUITING
Conditions: Crohn Disease|Ulcerative Colitis|Rheumatoid Arthritis|Ankylosing Spondylitis|Psoriatic Arthritis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Acupuncture in Treating Chronic Low-back Pain
Status: UNKNOWN
Conditions: Ankylosing Spondylitis|Low Back Pain
Interventions: OTHER: Yaotong points acupuncture|OTHER: the usual care|OTHER: standardized acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Safety and Preliminary Efficacy of ATA3219 in Participants With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
Status: RECRUITING
Conditions: Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
Interventions: DRUG: ATA3219
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Understanding and Modeling Reservoirs, Vehicles and Transmission of ESBL-producing Enterobacteriaceae in the Community and Long Term Care Facilities
Status: COMPLETED
Conditions: Resistance Bacterial|Enterobacteriaceae Infections
Interventions: BIOLOGICAL: ESBL-producing enterobacteriaceae carriage
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetic Non-interaction Study With a Fixed-dose Combination Tablet With Tramadol and Diclofenac
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Diclofenac sodium 25 mg|DRUG: Tramadol hydrochloride 25 mg|DRUG: Diclofenac sodium 25 mg/Tramadol hydrochloride 25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Efavirenz 400mg vs. 600mg Combined With Lamivudine and Tenofovir in Treatment Naive HIV Infection
Status: UNKNOWN
Conditions: HIV/AIDS|Mental Impairment
Interventions: DRUG: Efavirenz 400Mg Oral Tablet|DRUG: Efavirenz 600Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluciclovine F18 PET/CT Imaging in Assessing Hormone-Naive Men With Prostate Cancer That Has Spread to the Bone
Status: COMPLETED
Conditions: Metastatic Prostate Carcinoma|Prostate Carcinoma Metastatic in the Bone|Stage IV Prostate Cancer
Interventions: PROCEDURE: Computed Tomography|DRUG: Fluciclovine F18|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cortico-Spinal tDCS as Rehabilitative Intervention in Amyotrophic Lateral Sclerosis
Status: COMPLETED
Conditions: Motor Neuron Disease, Familial|Amyotrophic Lateral Sclerosis With Dementia
Interventions: DEVICE: Anodal bilateral motor cortex and cathodal spinal tDCS|DEVICE: Sham bilateral motor cortex and sham spinal tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Timing of Ambulation and Infant Birth Weight in Gestational Diabetes
Status: RECRUITING
Conditions: Gestational Diabetes|Pregnancy Complications|Pregnancy in Diabetic|Fetal Macrosomia
Interventions: BEHAVIORAL: Postprandial ambulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project JAY THA Registration Study
Status: COMPLETED
Conditions: Osteoarthritis|Rheumatoid Arthritis|Post-traumatic Arthritis|Avascular Necrosis|Developmental Dysplasia of the Hip|Femoral Neck Fracture
Interventions: DEVICE: Delta PLUS Femoral Head + SL-TWIN Stem|DEVICE: BIOLOX forte ball head + SL-PLUS Stem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Voice Treatment for Parkinson's Disease
Status: COMPLETED
Conditions: Idiopathic Parkinson Disease
Interventions: BEHAVIORAL: Lee Silverman Voice Treatment|DEVICE: SpeechVive|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Immuonosuppressant Drugs in Spring Catarrh
Status: UNKNOWN
Conditions: Vernal Keratoconjunctivitis
Interventions: DRUG: Prednisolone (as Acetate)|DRUG: CycloSPORINE Ophthalmic Suspension|DRUG: LTacrolimus Topical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy and Psychological Effects of Treating Antiretroviral Drug-Induced Facial Lipoatrophy With Bio-Alcamid
Status: COMPLETED
Conditions: Human Immunodeficiency Virus|Facial Lipoatrophy
Interventions: DEVICE: BIO-ALCAMID SOFT TISSUE ENDOPROSTHESIS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BMS-986218 or BMS-986218 Plus Nivolumab in Combination With Docetaxel in Participants With Metastatic Castration-resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasms, Castration-Resistant
Interventions: BIOLOGICAL: BMS-986218|DRUG: Docetaxel|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Otago Exercise Program vs Circuit Training on Balance in Chronic Obstructive Pulmonary Disease Patients
Status: COMPLETED
Conditions: COPD
Interventions: OTHER: Otago Exercise training|OTHER: Circuit training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PK/PD Levobupivacaine With and Without Epinephrine After Ultrasound Guided ESP Block
Status: UNKNOWN
Conditions: Anesthetics Complications|Anesthetic Toxicity|Bupivacaine Overdose|Nerve Block|Surgery
Interventions: DRUG: Levobupivacaine 0.25% with epinephrine 5 ug/ml|DRUG: Levobupivacaine 0.25% without epinephrine 5 ug/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity, Efficacy and Safety Trial of the Convacell Vaccine in Healthy Volunteers Aged 18 Years and Older
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19|Coronavirus Infections|Respiratory Tract Infections|COVID-19 Respiratory Infection
Interventions: BIOLOGICAL: Subunit recombinant vaccine for the prevention of coronavirus infection|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
Status: RECRUITING
Conditions: Brain Tumor, Recurrent|Brain Tumor|Brain Tumor, Primary|Brain Tumor - Metastatic|Brain Tumor, Adult: Glioblastoma|Brain Tumor, Adult Meningioma
Interventions: DEVICE: GammaTile
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ophthalmologic Examinations After Infusion of ZK200775
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DRUG: ZK200775|DRUG: ZK200775|DRUG: Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Second-line Treatment of HIV-1 With Ritonavir Boosted Atazanavir or Darunavir With an Optimized NRTI Backbone
Status: WITHDRAWN
Conditions: HIV
Interventions: DRUG: Atazanavir|DRUG: Darunavir|DRUG: Ritonavir|DRUG: Optimized NRTI backbone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Osimertinib With Chemotherapy as First-line Therapy for EGFR Mutation-positive NSCLC
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung|Lung Neoplasms|Respiratory Tract Neoplasms|Thoracic Neoplasms|Neoplasms by Site|Neoplasms|Lung Diseases|Respiratory Tract Diseases|Carcinoma, Bronchogenic|Bronchial Neoplasms
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Safety and Efficacy Test of Immuncell-LC to Treat Refractory Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: BIOLOGICAL: Immuncell-LC intravenous infusion using a CIK cell agent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transvaginal Ultrasound: Preterm Birth Prevention in Appalachia
Status: COMPLETED
Conditions: Preterm Birth
Interventions: BEHAVIORAL: Participant Barriers to TVU Screening|BEHAVIORAL: Provider Barriers to TVU Screening
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Combined Use of Immunoglobulin and Pulse Steroid Therapies in Severe Covid-19 Patients
Status: COMPLETED
Conditions: Pulse Steroid and Immunoglobulins Drugs in Covid 19 Patients
Interventions: DRUG: pulse steroid and nanogam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison Between 5% Albumin and 6% Hydroxyethyl Starch 130/0.4 in Priming Solution for Cardiopulmonary Bypass and Post-bypass Maintenance Fluid in High-risk Patients
Status: COMPLETED
Conditions: Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass
Interventions: DRUG: Hydroxyethyl starch 130/0.4|DRUG: Hydroxyethyl starch 130/0.4|DRUG: Hydroxyethyl starch 130/0.4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility of Metformin for Sepsis Induced AKI
Status: ENROLLING_BY_INVITATION
Conditions: Sepsis|Septic Shock|Acute Kidney Injury|Metformin
Interventions: DRUG: Metformin low dose|DRUG: Metformin high dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Risks for Non-fatal Venous Thromboembolism, Ischemic Stroke and Myocardial Infarction in Users of ORTHO EVRA(Norelgestromin and Ethinyl Estradiol Contraceptive Patch) Compared to Levonorgestrel-containing Oral Contraceptives.
Status: COMPLETED
Conditions: Contraception|Female Contraception|Fertility Control
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Bicuspid Aortic Stenosis Following Transcatheter Aortic Valve Replacement Registry
Status: COMPLETED
Conditions: Aortic Valve Stenosis|Cardiovascular Diseases|Heart Valve Diseases|Bicuspid
Interventions: PROCEDURE: transcatheter aortic valve replacement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Optimized Glycemic Control in Heart Failure Patients With DM2:"Effect on Left Ventricular Function and Skeletal Muscle"
Status: COMPLETED
Conditions: Type 2 Diabetes|Heart Failure
Interventions: OTHER: all antidiabetic drugs will be appliable
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Administration of Peptides; Absorption From Gastrointestinal Tract
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Increasing doses of GLP-1|DRUG: PYY3-36
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Color Doppler US and TE as Predictors for Presence of Gastroesophageal Varices and Variceal Bleeding in Patients With LC
Status: NOT_YET_RECRUITING
Conditions: Gastroesophageal Varices Hemorrhage
Interventions: DEVICE: color doppler ultrasound, transient elastography, upper endoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cabozantinib-S-Malate and Vemurafenib in Treating Patients With Solid Tumors or Melanoma That is Metastatic or That Cannot Be Removed By Surgery
Status: TERMINATED
Conditions: Recurrent Melanoma|Stage IIIA Melanoma|Stage IIIB Melanoma|Stage IIIC Melanoma|Stage IV Melanoma|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: cabozantinib-s-malate|DRUG: vemurafenib|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Extracorporeal Photopheresis (ECP) in the Treatment of Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis|Multiple Sclerosis, Relapsing-Remitting|Multiple Sclerosis, Secondary Progressive
Interventions: COMBINATION_PRODUCT: Extracorporeal Photopheresis|COMBINATION_PRODUCT: MS standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of MP-424, Peginterferon Alfa-2b and Ribavirin in Non-responder Genotype 2 Hepatitis C Infected Patients
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: MP-424 (generic name:Telaprevir)|DRUG: Ribavirin|DRUG: Peginterferon alfa-2b
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness Study of Physical Therapy as an Adjunct to a Lumbar Therapeutic Selective Nerve Root Block
Status: COMPLETED
Conditions: Sciatic Neuropathy|Radiculopathy|Intervertebral Disk Displacement
Interventions: OTHER: Lumbar injection|OTHER: Rehabilitation following lumbar injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Topical Hydrocortisone on Signs and Symptoms of Dry Eye Associated to Meibomian Gland Dysfunction
Status: RECRUITING
Conditions: Dry Eye|Meibomian Gland Dysfunction
Interventions: DRUG: Hydrocortisone Ophthalmic|DEVICE: MGD Rx EyeBag® eyelid warming device|DEVICE: Lephanet® lid wipes|DEVICE: Thealoz Duo® artificial tear with trehalose 3% and sodium hyaluronate 0.15%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Tooth Restoration in the Maxilla Using the Straumann® PURE® Ceramic Implant Monotype: One Year Follow up
Status: COMPLETED
Conditions: Ceramic Implant
Interventions: DEVICE: Straumann Pure Ceramic Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2/3 Study of HB-202/HB-201 With Pembrolizumab in Patients With HPV16+ Recurrent/Metastatic Oropharyngeal Cancer
Status: NOT_YET_RECRUITING
Conditions: Oropharyngeal Squamous Cell Carcinoma Recurrent
Interventions: DRUG: HB-202/HB-201 alternating 2-vector therapy|DRUG: Placebo|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety And PK Study Of CVX-060 In Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors|Neoplasms|Carcinoma|Cancer|Malignancy
Interventions: BIOLOGICAL: CVX-060
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Efficacy of Topical ARYS-01 (Sorivudine) Cream 3%, Oral Valaciclovir and Combination ARYS-01 Cream 3%/Oral Valaciclovir for Treatment of Herpes Zoster (Shingles)
Status: UNKNOWN
Conditions: Herpes Zoster|Postherpetic Neuralgia
Interventions: DRUG: ARYS-01 (sorivudine) cream 3% or placebo cream|DRUG: placebo|DRUG: valaciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF
Status: COMPLETED
Conditions: Heart Failure|Heart Failure, Diastolic|Heart Failure With Preserved Ejection Fraction|Cardiac Failure|Heart Disease
Interventions: DRUG: Beta blockers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Culturally Tailored Nurse Coaching Study for Cancer Symptom Management
Status: COMPLETED
Conditions: Dehydration|Symptom Cluster|Quality of Life|Self Efficacy|Chemotherapy Effect
Interventions: BEHAVIORAL: CTNSM|BEHAVIORAL: Standard of Care Chemotherapy Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Understanding and Discouraging Overuse of Potentially Harmful Screening Tests
Status: COMPLETED
Conditions: Preventive Screening|Prostate Cancer|Osteoporosis|Colorectal Cancer
Interventions: BEHAVIORAL: Quantitative Information Sheet|BEHAVIORAL: Qualitative Information Sheet|BEHAVIORAL: Narrative Information Sheet|BEHAVIORAL: Framed Information Sheet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: PD-1 +/- IL-4 Inhibition in ER+ Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Arm A: Cemiplimab, Arm B: Cemiplimab + Dupilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Insulin Dose Titration System Using a Short Messaging Service (SMS) Automatically Produced by a Knowledge Matrix
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Insulin dose titration system using a SMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of a Low-cost Warming Mattress Celsi Warmer for the Management of Hypothermic Newborns at Muhimbili National Hospital, Dar es Salaam, Tanzania
Status: RECRUITING
Conditions: Neonatal Hypothermia
Interventions: DEVICE: Celsi Warmer Mattress
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Lubiprostone and PEG Preparation Versus Conventional PEG Preparation for Colonoscopy
Status: COMPLETED
Conditions: Colorectal Carcinoma
Interventions: DRUG: Lubiprostone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Oral Anticoagulant Therapy for Venous Thrombosis - SCOR in Thrombosis
Status: COMPLETED
Conditions: Venous Thrombosis|Cardiovascular Diseases|Venous Thromboembolism
Interventions: DRUG: warfarin|DRUG: heparin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Imatinib Mesylate in Hypereosinophilic Syndromes
Status: COMPLETED
Conditions: Hypereosinophilic Syndrome|Chronic Eosinophilic Leukemia|Chronic Idiopathic Hypereosinophilia
Interventions: DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Search Cytomegalovirus in Healthy Volunteers Stools Samples Selected as Potential Donor for Fecal Microbiota Transplant
Status: COMPLETED
Conditions: CMV|Healthy Volunteers
Interventions: OTHER: Blood and stool samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Irrigation Activation on Clinical Outcomes of Root Canal Treatment
Status: COMPLETED
Conditions: Periapical Periodontitis|Root Canal Infection
Interventions: PROCEDURE: three irrigation activation methods|PROCEDURE: conventional needle irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Psilocybin Therapy in Advanced Cancer
Status: RECRUITING
Conditions: Advanced Cancer
Interventions: DRUG: Psilocybin 25 mgs|DRUG: Niacin 100mg|BEHAVIORAL: Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Performance and Tolerability of a New Medical Device Gel, a Randomized, Open Label, Parallel-group, Multicentre Study
Status: COMPLETED
Conditions: Tooth Disease
Interventions: DEVICE: HA BPX V3.3|OTHER: Dentinox-Gel N
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Tolerability Study of UBX1325 in Patients With Diabetic Macular Edema or Neovascular Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Diabetic Macular Edema|Neovascular Age-related Macular Degeneration
Interventions: DRUG: UBX1325
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration
Status: RECRUITING
Conditions: Geographic Atrophy
Interventions: DRUG: Pegcetacoplan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Anorectal Dysfunction in Patients Suffering From Spina Bifida : From Clinic to Neuro-epithelial Function (ANOSPIN)
Status: UNKNOWN
Conditions: Spina Bifida
Interventions: PROCEDURE: Colonic biopsies during endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Blood Based Eyedrops From Different Sources in the Treatment of Severe Keratopathy
Status: UNKNOWN
Conditions: Keratopathy|Sjogren's Syndrome|GVHD - Graft-Versus-Host Disease
Interventions: OTHER: CBS eyedrops|OTHER: PBS eyedrops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Tolerability and Pharmacokinetics of CKD-386(3) 80/20/10mg
Status: COMPLETED
Conditions: Hypertension and Dyslipidemia
Interventions: DRUG: CKD-386(3)|DRUG: D013, D326, D337
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Quercetin Increase Claudin-4 and Improve Esophageal Barrier Function in GERD?
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease|GERD|Acid Reflux|Reflux
Interventions: DRUG: Quercetin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sedation Versus General Anesthesia for Endovascular Therapy in Acute Stroke - Impact on Neurological Outcome
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: Sevorane Remifentanil|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of a Retroviral Replicating Vector Combined With a Prodrug Administered to Patients With Recurrent Malignant Glioma
Status: COMPLETED
Conditions: Glioblastoma|Anaplastic Astrocytoma|Anaplastic Oligodendroglioma|Anaplastic Oligoastrocytoma
Interventions: BIOLOGICAL: Toca 511 vector|DRUG: Toca FC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Treatment Study Comparing Two Non-Drug, Self-Help Treatment of Chronic Insomnia.
Status: UNKNOWN
Conditions: Insomnia
Interventions: BEHAVIORAL: Computerized delivery of cognitive-behavioral treatment of insomnia|BEHAVIORAL: Self-help manual to improve insomnia symptoms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Music Therapy for Pain Modification in Pediatric Palliative Care
Status: COMPLETED
Conditions: Neurological Impairment
Interventions: BEHAVIORAL: Live guitar and vocal music therapy|BEHAVIORAL: Vibroacoustic Music Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Carfilzomib, Lenalidomide, and Dexamethasone in New Multiple Myeloma Patients
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Carfilzomib|DRUG: Lenalidomide|DRUG: Dexamethasone|DRUG: Lenalidomide|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Asthma Exacerbation Study
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone Furoate/GW642444|DRUG: Fluticasone furoate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Inclusion of Mobilisation With Movement to an Exercise Programme in Rotator Cuff Related Pain
Status: UNKNOWN
Conditions: Rotator Cuff Injuries|Shoulder Pain
Interventions: OTHER: Mobilisation with Movement|OTHER: Sham Mobilisation with Movement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of NPC-14 (Arbekacin Sulfate) to Explore Safety, Tolerability, and Efficacy in Duchenne Muscular Dystrophy
Status: UNKNOWN
Conditions: Muscular Dystrophy, Duchenne
Interventions: DRUG: NPC-14|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ABILITY - TelerehABILITation: TechnologY-enhanced Multi-domain at Home Continuum of Care Program
Status: COMPLETED
Conditions: Cognitive Impairments|Dementia|Alzheimer Disease
Interventions: OTHER: Ability platform program|OTHER: Usual care program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Capecitabine or Observation After Surgery in Treating Patients With Biliary Tract Cancer
Status: COMPLETED
Conditions: Extrahepatic Bile Duct Cancer|Gallbladder Cancer|Liver Cancer
Interventions: DRUG: capecitabine|OTHER: clinical observation|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Mother's Touch and Nurse's Therapeutic Touch on Pain Level and Crying Time During Heel Blood Collection
Status: RECRUITING
Conditions: Pain, Acute|Newborn|Crying
Interventions: BEHAVIORAL: Mother's Touch|BEHAVIORAL: Nurse's Therapeutic Touch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Aortic Cross Clamping Time, and Postoperative Respiratory Function
Status: COMPLETED
Conditions: Bypass Complication|Respiratory Complication
Interventions: PROCEDURE: aortic cross clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of a Vibratory Stimulus on Mitigating Nociception-specific Responses to Skin Puncture in Neonates
Status: COMPLETED
Conditions: Infant, Newborn|Infant, Premature|Pain Perception|Pain Measurement|Pain Management|Electroencephalography
Interventions: DEVICE: Baby GentleStick
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study of Tocilizumab in the Treatment of Idiopathic Retroperitoneal Fibrosis
Status: UNKNOWN
Conditions: Idiopathic Retroperitoneal Fibrosis
Interventions: DRUG: Tocilizumab|DRUG: Glucocorticoids
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Virtual Reality Technology for Pain Management of Vaso-Occlusive Crisis in Patients With Sickle Cell Disease
Status: RECRUITING
Conditions: Sickle Cell Disease|Vaso-occlusive Crisis
Interventions: OTHER: Virtual Reality Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Morphine Versus Ketamine as Adjuvants in Paravertebral Blocks
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain, Postoperative|Pain, Acute|Pain, Chronic|Pain, Neuropathic|Morphine|Ketamine|Analgesia
Interventions: DRUG: local anesthetic-morphine|DRUG: local anesthetic-ketamine|DRUG: local anesthetic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Spectrometry (MRM) Versus I 125 Radioimmunoassay (RIA) for Quantification of Orexin-A of Patients With Hypersomnolence
Status: RECRUITING
Conditions: Narcolepsy|Idiopathic Hypersomnia|Cataplexy
Interventions: DIAGNOSTIC_TEST: Quantitative mass spectrometry assay
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: D-PLEX 302: Efficacy and Safety of D-PLEX in the Prevention of Sternal Infection Post Cardiac Surgery
Status: TERMINATED
Conditions: Surgical Site Infection|Sternal Infection|Cardiac Surgery
Interventions: DRUG: D-PLEX|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: VELCADE-Thalidomide-Dexamethasone (VTD) vs Thalidomide-Dexamethasone (TD) Incorporated Into Double Autotransplantation for Untreated Multiple Myeloma (MM)
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Velcade|DRUG: Thalidomide|DRUG: Dexamethasone|PROCEDURE: Peripheral Blood Stem Cell (PBSC) collection|PROCEDURE: First Autologous Transplantation|PROCEDURE: Second Autologous Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Efficacy of a Mobile App Intervention to Change Youth and Their Families' Health Behaviours
Status: COMPLETED
Conditions: Obesity, Pediatric
Interventions: BEHAVIORAL: Aim2Be app with Live Coach + Fitbit + BMI tracking tools|BEHAVIORAL: Aim2Be app waitlist + Canadian Health Recommendations + Fitbit + BMI tracking tools, then flip to Aim2Be app with Virtual Coach + Fitbit + BMI tracking tools
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of "Roll-over' Technique With Standard Abdominal Paracentesis in Suspected Peritoneal Carcinomatosis
Status: TERMINATED
Conditions: Ascites|Peritoneal Carcinomatosis|Peritoneum Neoplasm|Tuberculous Peritonitis
Interventions: PROCEDURE: Standard Paracentesis|PROCEDURE: Roll Over Paracentesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Live Attenuated Japanese Encephalitis (JE) Vaccine Coadministered With Measles Vaccine in Infants 9 Months of Age
Status: COMPLETED
Conditions: Japanese Encephalitis
Interventions: BIOLOGICAL: Live, Attenuated Japanese Encephalitis SA 14-14-2 Vaccine|BIOLOGICAL: Live, attenuated measles vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prevention of Skin Cancer in High Risk Patients After Conversion to a Sirolimus-based Immunosuppressive Protocol
Status: TERMINATED
Conditions: Kidney Transplantation|Skin Cancer
Interventions: DRUG: Sirolimus|DRUG: Azathioprine|DRUG: Mycophenolate|DRUG: Ciclosporin|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Caffeine and Training Intensity Quantification
Status: NOT_YET_RECRUITING
Conditions: Caffeine
Interventions: DRUG: Low caffeine dose|DRUG: Moderate caffeine dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Baker Cyst Dimensions and Intermittent Vacuum Therapy in Knee Osteoarthritis (BCIVT)
Status: COMPLETED
Conditions: Baker Cyst|Knee Osteoarthritis
Interventions: DEVICE: Intermittent vacuum therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Resynchronization Therapy in Congenital Heart Defects
Status: COMPLETED
Conditions: Congenital Heart Defects
Interventions: DEVICE: Implantation and testing of CRT|DEVICE: Implantation and testing of CRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hydrophobic Acrylic Toric IOL Designed to Reduce the Effects of Preoperative Corneal Astigmatism
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: enVista® One-Piece Hydrophobic Acrylic Toric IOL|DEVICE: enVista control lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Quality of Global and Sexual Life and Impact of Surgical and Non Surgical Vaginal Aplasia in Patients With a Rokitansky Syndrome
Status: COMPLETED
Conditions: Rokitansky Syndrome|Surgical or Vaginal Dilatation of Vaginal Aplasia
Interventions: BEHAVIORAL: evaluate quality of life of surgical and non surgical vaginal aplasia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy After Selective Intra-arterial Thrombolysis for Central Retinal Artery Occlusion
Status: UNKNOWN
Conditions: Central Retinal Artery Occlusion
Interventions: PROCEDURE: intra-arterial thrombolysis|OTHER: conservative treatments
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity
Status: COMPLETED
Conditions: SCAD|Addison Disease|Ankylosing Spondylitis|Antiphospholipid Antibody Syndrome|Celiac Disease|Crohn Disease|Dermatomyositis|Polymyositis|Guillain-Barre Syndrome|Hepatitis, Autoimmune|Graves Disease|Hashimoto Thyroiditis|Multiple Sclerosis|Myasthenia Gravis|Pernicious Anemia|Polymyalgia Rheumatica|Primary Biliary Cirrhosis|Psoriasis|Rheumatoid Arthritis|Systemic Sclerosis|Sjögren Syndrome|Systemic Lupus Erythematosus|Takayasu Arteritis|Type 1 Diabetes Mellitus|Ulcerative Colitis|Uveitis|Vasculitis|Vitiligo|Raynaud
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Linaclotide in Type II Diabetics With Chronic Constipation
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Constipation|Diabete Mellitus
Interventions: DRUG: linaclotide or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: PROCEDURE: acupuncture|PROCEDURE: minimal (sham)acupuncture|DRUG: cetirizine dihydrochloride (rescue medication)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Early Patient Removal of Urinary Catheters After Urogynecologic Surgery
Status: RECRUITING
Conditions: Urinary Retention Postoperative|Postoperative Urinary Tract Infection|Catheter Site Pain
Interventions: PROCEDURE: Early catheter removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of BL-M07D1 in Patients With a Variety of Solid Tumors Including Locally Advanced or Metastatic HER2-positive/Low-expressing Urinary and Gastrointestinal Tumors
Status: RECRUITING
Conditions: Her2-positive/Low-expression Urinary and Digestive Tract Tumors
Interventions: DRUG: BL-M07D1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetic Properties and Preliminary Efficacy of 9MW3811 in Patients With Advanced Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced Malignant Solid Tumor
Interventions: DRUG: 9MW3811 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pramipexole Extended Release in the Treatment of Essential Tremor
Status: WITHDRAWN
Conditions: Essential Tremor
Interventions: DRUG: pramipexole|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Osteopathic Manipulative Treatment and Its Relationship to Autonomic Nervous System Activity
Status: COMPLETED
Conditions: Healthy
Interventions: PROCEDURE: Placebo|PROCEDURE: Sham|PROCEDURE: OMT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Manipulation of Oocytes and Embryos in Low Oxygen Tension on Assisted Reproduction Technology Outcome
Status: UNKNOWN
Conditions: Embryo Hypoxia
Interventions: BIOLOGICAL: 5% O2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: IMPACT (IMproving Proactive Approaches for Cancer Survivors' Mental Health Treatment)
Status: NOT_YET_RECRUITING
Conditions: Depression|Depressive Symptoms|Cancer
Interventions: BEHAVIORAL: Behavioral Activation Therapy App|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of EndoChoice's Upper&Lower Endoscopic Systems Utilizing a Full Spectrum Optical Technology
Status: COMPLETED
Conditions: Gastrointestinal Diseases
Interventions: DEVICE: Endoscopy exploratory single arm (EndoChoice FUSE(TM) System)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ventilator Hyperinflation and Manual Rib Cage Compression
Status: COMPLETED
Conditions: Pulmonary Atelectasis
Interventions: OTHER: Expiratory Rib Cage Compression|OTHER: Compression + Ventilator Hyperinflation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Metformin on Carotid Atherosclerosis for Non-diabetic Patients With PsA (CAMPA Study)
Status: RECRUITING
Conditions: PsA (Psoriatic Arthritis)
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remotely Delivered Programs Targeting COVID-19 Stress-Related Depression and Substance Use
Status: COMPLETED
Conditions: Depression|Anxiety|Substance Use|Stress, Psychological|Stress, Emotional|Alcohol Use, Unspecified|Drug Use|Covid19
Interventions: BEHAVIORAL: Mindfulness Based Cognitive Therapy for Resilience During COVID-19 plus CHAMindWell|BEHAVIORAL: Internet Cognitive Behavioral Therapy plus CHAMindWell|BEHAVIORAL: CHAMindWell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility & Effect of a Tele-rehabilitation Program for Chronic Obstructive Pulmonary Disease vs. Standard Rehabilitation
Status: UNKNOWN
Conditions: COPD
Interventions: COMBINATION_PRODUCT: Tele Rehab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of CDX-0159 in Patients With Eosinophilic Esophagitis
Status: RECRUITING
Conditions: Eosinophilic Esophagitis
Interventions: BIOLOGICAL: barzolvolimab|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of an Intervention in Multicomponent Exercise in Patients Over 70 Years in Primary Care
Status: TERMINATED
Conditions: Frail Elderly|Physical Activity
Interventions: OTHER: MEFAP|OTHER: control usual practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Immunogenicity Study of LC16m8, a Modified Smallpox Vaccine, in Healthy, Previously Unvaccinated Volunteers
Status: UNKNOWN
Conditions: Smallpox
Interventions: BIOLOGICAL: LC16m8 Smallpox Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Gadopiclenol Pharmacokinetics, Safety and Efficacy in Children < 2 Years of Age
Status: ACTIVE_NOT_RECRUITING
Conditions: Central Nervous System Diseases|Pediatric Disorder|Body Indication
Interventions: DRUG: Gadopiclenol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC