pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Influence of Lifestyle, Inflammatory Biomarkers, and Genetic Factors on Long-term Breast Cancer Prognosis
Status: COMPLETED
Conditions: Breast Cancer|Breast Cancer Mortality|Breast Cancer Survival|Postmenopausal Breast Cancer|Lifestyle|Genetic Factors|Inflammation|Inflammatory Biomarkers|Hormone Therapy|Phytoestrogens
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tadalafil Taken Daily Compared to Placebo on Improvement of Getting and Maintaining an Erection and Sexual Quality of Life
Status: COMPLETED
Conditions: Impotence
Interventions: DRUG: tadalafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Chronic Active Antibody Mediated Rejection After Kidney Transplantation by Double-Filtration PlasmaPheresis or Plasma Exchange
Status: UNKNOWN
Conditions: Kidney Transplantation|Antibody Mediated Rejection
Interventions: OTHER: Sessions of conventional apheresis|OTHER: Sessions of news apheresis with double filtration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy at 24 Weeks With Long Term Safety, Tolerability and Efficacy up to 5 Years of Secukinumab in Patients of Active Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Secukinumab (AIN457)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Liver and Spleen Stiffness Measured by 2D-SWE for Diagnosis of Liver Fibrosis in Patients With cACLD
Status: RECRUITING
Conditions: Liver Fibrosis|Liver Cirrhosis
Interventions: DIAGNOSTIC_TEST: Diagnostic Test: Transient elastography (TE) and 2D-shear wave elastography (2D-SWE)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: EMDR Therapy in Young Children, a Double-blinded Randomized Controlled Trial
Status: RECRUITING
Conditions: Trauma, Psychological|Stress, Psychological|Anxiety Disorders
Interventions: BEHAVIORAL: EMDR therapy|BEHAVIORAL: Routine Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Graft Reinforcement for Posterior Nasal Nerve Neurectomy in Allergic Rhinitis Surgeries
Status: COMPLETED
Conditions: Neurectomy
Interventions: PROCEDURE: conventional posterior nerve neurectomy|PROCEDURE: cartilage graft reinforcement after posterior nerve neurectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic and Antihyperalgesic Effects of Morphine and Buprenorphine
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: morphine LO|DRUG: Morphine Hi|DRUG: Buprenorphine LO|DRUG: Buprenorphine Hi|OTHER: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of DEXTENZA in the Management of Pain and Inflammation in Patients With Anterior Uveitis Compared to Standard of Care Topical Corticosteroids
Status: UNKNOWN
Conditions: Non-infectious Anterior Uveitis
Interventions: DEVICE: Dextenza Dexamethasone Implant|DRUG: Topical Prednisolone Acetate 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pioglitazone for Lung Cancer Chemoprevention
Status: COMPLETED
Conditions: Lung Cancer|Endobronchial Dysplasia
Interventions: PROCEDURE: fluorescence bronchoscopy|PROCEDURE: quantitative high resolution CT scan|DRUG: PIOGLITAZONE VS. PLACEBO 30 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy on Cell-based Therapy in Patients With Recent Large Acute Myocardial Infarction
Status: WITHDRAWN
Conditions: Acute Myocardial Infarction|Heart Failure
Interventions: BIOLOGICAL: Intracoronary delivery of unfractionated bone marrow mononuclear cells|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Rehabilitation in Advanced aGE: EXercise TRaining and Active Follow-up CR-AGE-EXTRA Trial
Status: UNKNOWN
Conditions: Cardiovascular Disease
Interventions: OTHER: A: Home-Based exercise after Cardiac Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence and Food Effect Study of SEP-190 in Japanese Healthy Subjects (Study SEP 190-102)
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: Eszopiclone 3 mg|DRUG: Eszopiclone 1 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Progressive Relaxation Exercise on Pain and Kinesiophobia After Lumbar Disc Herniation Surgery
Status: COMPLETED
Conditions: Lumbar Disc Herniation
Interventions: OTHER: Progressive relaxation exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Usefulness of the Use of Co-registration Strategy With iFR in Long and/or Diffuse Coronary Lesions
Status: ACTIVE_NOT_RECRUITING
Conditions: Instantaneous Wave Free Ratio|Diffuse Coronary Artery Disease|Long Coronary Lesion|Syncvision Software
Interventions: DEVICE: iFR pullback with Syncvision software (Volcano company)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-administered Lidocaine Gel for Pain-control During Cervical Preparation for Dilation and Evacuation
Status: COMPLETED
Conditions: Pain Management, Cervical Preparation
Interventions: DRUG: Lidocaine Gel (2%)|DRUG: Lidocaine Paracervical Block (1%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Trial of Povidone-iodine Suppository Before Transrectal Ultrasound Guided Prostate Biopsy
Status: UNKNOWN
Conditions: Infection|Prostatic Diseases|Misadventure During Aspirating Needle Biopsy
Interventions: DRUG: Povidone-Iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dry Eye Treatment With Artificial Tears
Status: COMPLETED
Conditions: Dry Eye
Interventions: OTHER: Hypromellose 0.15%|OTHER: Hypromellose 0.4%|OTHER: Carboxymethylcellulose|OTHER: Liposomal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Compression Garments on Exercise Performance Following Acute High Intensity Exercise
Status: COMPLETED
Conditions: Muscle Damage
Interventions: OTHER: Far Infrared Fabric|OTHER: Spandex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Utilization of Confocal Microscopy During Cardiac Surgery
Status: COMPLETED
Conditions: Atrial Septal Defect
Interventions: DRUG: Fluorescite|DEVICE: Cellvizio 100 Series System with Confocal Miniprobes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Tolerability of GX-I7 in HPV-infected Female Volunteers
Status: COMPLETED
Conditions: Human Papillomavirus
Interventions: DRUG: GX-I7|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjunctive GNX Treatment Compared With Placebo in Children and Adults With TSC-related Epilepsy
Status: ACTIVE_NOT_RECRUITING
Conditions: Tuberous Sclerosis Complex
Interventions: DRUG: Ganaxalone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Miravirsen Study in Null Responder to Pegylated Interferon Alpha Plus Ribavirin Subjects With Chronic Hepatitis C
Status: UNKNOWN
Conditions: Hepatitis C
Interventions: DRUG: Miravirsen sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The CHORAL Flow Study
Status: TERMINATED
Conditions: Coronary Artery Disease|Atherosclerosis|Hyperlipidemias
Interventions: BIOLOGICAL: Evolocumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Deambulatory Epidural During the Labour
Status: COMPLETED
Conditions: First Pregnancy
Interventions: DRUG: Levobupivacaine 0.1% + Sufentanil 0.2µg/ml|DRUG: Levobupivacaine 0.07% + Sufentanil 0.3µg/ml|PROCEDURE: Lumbar epidural analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Automated Physician-Directed Messaging on Patient Engagement in the Digital Diabetes Prevention Program
Status: ACTIVE_NOT_RECRUITING
Conditions: Pre Diabetes
Interventions: OTHER: Digital diabetes prevention program (dDPP)|OTHER: Adapted dDPP-EHR tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: INNOVE Study: A Study of 3 Months Induction With Fuzeon (Enfuvirtide) + Optimized Background (OB) Versus OB Alone in HIV-1 Infected Patients With Virological Failure.
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: enfuvirtide [Fuzeon]|DRUG: Optimized background ARV therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ILX651 in Patients With Hormone-Refractory Prostate Cancer Previously Treated With Docetaxel
Status: COMPLETED
Conditions: Hormone-refractory Prostate Cancer
Interventions: DRUG: ILX651
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Characterization of a Single 200 mg Dose of Doxycycline in Post-exposure Prophylaxis (PEP) of Sexually Transmitted Infections in Different Biological Compartments
Status: RECRUITING
Conditions: Post-exposure Prophylaxis|Sexually Transmitted Diseases|Doxycycline
Interventions: OTHER: Samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Ankle Sprains
Status: COMPLETED
Conditions: Ankle Sprains
Interventions: DRUG: MRX-7EAT|DRUG: Placebo|DRUG: Lidocaine|DRUG: Etodolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Intepirdine (RVT-101) in Subjects With Mild to Moderate Alzheimer's Disease on Donepezil: MINDSET Study
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: RVT-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Rituximab Plus Zanubrutinib Versus Rituximab Monotherapy in Untreated SMZL Patients
Status: RECRUITING
Conditions: Splenic Marginal Zone Lymphoma
Interventions: DRUG: Rituximab|DRUG: Zanubrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Efficacy of the of the Gastric-retentive AP-CD/LD in Advanced Parkinson's Patients
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: DRUG: Accordion Pill™ Carbidopa/Levodopa|DRUG: Sinemet®|DRUG: Placebo -AP-CD/LD|DRUG: Placebo- Sinemet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of AZLI in Children With Cystic Fibrosis (CF) and Chronic Pseudomonas Aeruginosa in the Lower Airways
Status: COMPLETED
Conditions: Cystic Fibrosis|Pseudomonas Aeruginosa
Interventions: DRUG: AZLI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zoledronate in Treating Patients With Cervical Intraepithelial Neoplasia 2/3 or 3
Status: TERMINATED
Conditions: Cervical Cancer|Precancerous Condition
Interventions: DRUG: Zoledronate|OTHER: Placebo (Saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of a Learning Program of Self- Rehabilitation Exercises by Mirror Therapy
Status: TERMINATED
Conditions: Reflex Sympathetic Dystrophy|Causalgia
Interventions: BEHAVIORAL: Mirror therapy|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Prediction of Hemorrhage Transformation by Cerebral Autoregulation in AIS Patient After Endovascular Thrombectomy
Status: ENROLLING_BY_INVITATION
Conditions: Acute Ischemic Stroke|Endovascular Thrombectomy|Dynamic Cerebral Autoregulation
Interventions: PROCEDURE: endovascular thrombectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Telephone-Based Program to Promote Inhaled Corticosteroid Adherence Among Individuals With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: Automated Phone-Based Refill Reminders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Televideo Exercise and Nutrition Program for Kidney Transplant Recipients
Status: COMPLETED
Conditions: Kidney Transplant Recipient|Diet Modification|Physical Activity
Interventions: BEHAVIORAL: Televideo Lifestyle Coaching|BEHAVIORAL: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Patients With Diabetic Neuropathy Who Receive Physiotherapy Treatment Will Have a Decrease in Diabetic Foot Ulcers
Status: UNKNOWN
Conditions: Diabetic Foot Ulcer|Diabetic Neuropathy Peripheral
Interventions: OTHER: Physiotherapy protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lumbopelvic Movement Control: Effect of Injury History, and the Role of Cortical Control and Its Practical Application 1
Status: COMPLETED
Conditions: Biomechanical Phenomena
Interventions: OTHER: core muscle training|OTHER: movement control training|OTHER: combined imagery and movement control training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Ultrasound Guided Versus Blind Corticosteroid Injection for Trochanteric Bursitis
Status: COMPLETED
Conditions: Bursitis
Interventions: PROCEDURE: Trochanter bursa injections|DEVICE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Deep Sclerectomy and Traditional Trabeculotomy & Trabeculectomy in Congenital Glaucoma
Status: UNKNOWN
Conditions: Congenital Glaucoma
Interventions: PROCEDURE: Deep Sclerectomy|PROCEDURE: Combined Trab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Imaging With a PET Agent for Detection of Cancers of the Head and Neck
Status: RECRUITING
Conditions: Head and Neck Cancer
Interventions: DRUG: [18F]- PARPi|DIAGNOSTIC_TEST: PET/CT Scans
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Lower and Higher Load Resistance Exercise Protocols: Acute Muscle Activation and Skeletal Muscle Hypertrophy
Status: COMPLETED
Conditions: Muscle Hypertrophy|Muscle Fibre Activation
Interventions: BEHAVIORAL: resistance exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Does Oral Magnesium Substitution Relieve Pregnancy Induced Leg Cramps ?
Status: COMPLETED
Conditions: Cramps
Interventions: DRUG: "Nycoplus Magnesium" (120 mg x 3 daily for 2 weeks)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Induced Pluripotent Stem Cell Derived Exosomes for the Treatment of Atopic Dermatitis
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: GD-iExo-001|OTHER: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PTH And Calcium Responses to Exercise (PACE) in Older Adults
Status: COMPLETED
Conditions: Osteoporosis
Interventions: PROCEDURE: Treadmill Exercise|PROCEDURE: Magnitude of Ca loss during Exercise at 26 degrees Celcius
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Oxymetazoline HCl Cream 1.0% in Patients With Persistent Erythema Associated With Rosacea
Status: COMPLETED
Conditions: Erythema|Rosacea
Interventions: DRUG: Oxymetazoline HCL Cream 1.0%|DRUG: Vehicle to Oxymetazoline HCL Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ''Efficacy of Locally Delivered Hyaluronic Acid Gel as an Adjunctive to Non-Surgical Management of Periodontitis
Status: COMPLETED
Conditions: Periodontitis
Interventions: DRUG: Hyaluronic acid|PROCEDURE: non surgical periodontal therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Investigate The Clearance Of PF-04776548 From The Body Following A Very Low (Micro) Dose Of The Compound Using A Low Level Of Radiotracer To Help Quantify Expected Low Concentrations Of PF-04776548 In The Body
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV)
Interventions: DRUG: PF-04776548
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy & Safety of Nintedanib in Patients With Progressive Fibrosing Coal Mine Dust-Induced Interstitial Lung Disease
Status: UNKNOWN
Conditions: Progressive Fibrosing Interstitial Lung Disease
Interventions: DRUG: Nintedanib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Care Programs for Female Pelvic Health
Status: ENROLLING_BY_INVITATION
Conditions: Pelvic Floor Disorders|Pelvic Pain|Pelvic Organ Prolapse|Pelvic Floor Muscle Weakness|Pelvic Pain Syndrome
Interventions: DEVICE: Bloom Pod
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ambroxol to Slow Progression in Parkinson Disease
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: Ambroxol Hydrochloride (420mg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: General Anesthesia Combined With Epidural Anesthesia Mitigates the Surgical Stress-related Immunosuppression in Patients With Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: PROCEDURE: epidural anesthesia|PROCEDURE: general anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate Safety and Immunologic Response of COMBIG-DC, in Patients With Metastatic Kidney Cancer
Status: COMPLETED
Conditions: Metastatic Renal Cell Carcinoma
Interventions: BIOLOGICAL: Combig-DC (allogeneic dendritic cells) Cancer Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of Dual-cantilevered Single-implant Bridge
Status: NOT_YET_RECRUITING
Conditions: Dental Implant Failed
Interventions: DEVICE: Dual-cantilevered implant bridge|DEVICE: 3-unit iFDP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Clinical Trial on Neoviderm Skin Emulsion and Connettivi-na 0.2% Cream to Evaluate the Normalization Process of the Skin and Re-duction of Cutaneous Tension and Pain in Patients With Superficial Burns Grade 1 and 2
Status: RECRUITING
Conditions: Dermatology
Interventions: DEVICE: Neoviderm Skin Emulsion medical device|DRUG: Connettivina 0.2% Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of XMT-2056 in Advanced/Recurrent Solid Tumors That Express HER2
Status: RECRUITING
Conditions: HER2-positive Breast Cancer|HER2-positive Gastric Cancer|HER2-positive Non-Small Cell Lung Cancer|HER2-positive Colorectal Cancer|HER2-positive Tumors|HER2 Low Breast Cancer
Interventions: DRUG: XMT-2056
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Tolerability Study of GB301
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: BIOLOGICAL: Regulatory T cells|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carbohydrate Use During and Following Exercise
Status: UNKNOWN
Conditions: Carbohydrate Oxidation and Glycogen Utilization During and Following Exercise
Interventions: DIETARY_SUPPLEMENT: Carbohydrate ingestion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Terazosin Effect on Cardiac Changes in Early Parkinson's Disease
Status: RECRUITING
Conditions: REM Sleep Behavior Disorder|Pre-motor Parkinson's Disease|Symptomatic Parkinson Disease
Interventions: DRUG: Terazosin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Traditional Chinese Medicine Combined With Thermal and Cold Ablation for Early-stage Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer Stage I
Interventions: COMBINATION_PRODUCT: traditional Chinese medicine and ablation in the primary tumor sites|PROCEDURE: ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy & Erlotinib in Treating Patients w/ Esophageal or Gastroesophageal Cancer That Cannot Be Removed by Surgery
Status: TERMINATED
Conditions: Esophageal Cancer
Interventions: DRUG: Erlotinib|DRUG: 5-fluorouracil|DRUG: Leucovorin|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Skin Temperature Gradient Effects on the Variation of Metabolic Hormones in Adults
Status: COMPLETED
Conditions: Temperature Change, Body|Stress|Metabolic Disturbance
Interventions: BEHAVIORAL: Mountainous setting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Investigation of the Effectiveness of Upper Limb Exercise in COPD Patients
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Arm Endurance Exercise Training|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Post-marketing Surveillance on Long Term Use of Ofev Capsules in Systemic Scleroderma Associated Interstitial Lung Disease (SSc-ILD) in Japan
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Diseases, Interstitial
Interventions: DRUG: Nintedanib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of YVOIRE Y-Solution 360 for Hand Augmentation to Correct Volume Loss
Status: TERMINATED
Conditions: Dorsal Hand Volume Loss
Interventions: DEVICE: YVOIRE Y-Solution 360
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Local Anaesthetics Articaine and Bupivacaine in Treatment of Acute Sternum Pain After Heart Surgery
Status: SUSPENDED
Conditions: Diseases of Mitral Valve|Aortic Valve Disorder|Atrial Septal Defects|Intracardiac Myxoma
Interventions: DRUG: Articaine hydrochloride 2% solution|DRUG: Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: New Technology to Differentiate Normal Gastric Mucosa From Helicobacter Pylori Associated Gastritis and Gastric Atrophy
Status: COMPLETED
Conditions: Gastritis|Helicobacter Pylori Associated Gastritis|Atrophic Gastritis
Interventions: DEVICE: Digital chromoendoscopy and magnification
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Univu-guided Vein of Marshall Ethanol Infusion (Marshall-Merge)
Status: RECRUITING
Conditions: Persistent Atrial Fibrillation|Longstanding Persistent Atrial Fibrillation
Interventions: PROCEDURE: Vein of Marshall ethanol infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prevention of CR-POPF in PD With the Technique of Connexion the Pancreatic Duct to Jejunum Stented (CONDUCTJE-ST).
Status: COMPLETED
Conditions: Pancreas Disease|Fistula Pancreatic
Interventions: PROCEDURE: Pancreaticoduodenectomy with the CONDUCTJE-ST technique
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: RC48 Plus AK104 as First-line Treatment for HER2-overexpressing Advanced Gastric Cancer
Status: NOT_YET_RECRUITING
Conditions: HER2-positive Gastric Cancer
Interventions: DRUG: Disitamab Vedotin|DRUG: Cadonilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-oxygenation With High-flow Nasal Cannula in Caesarian Section Under General Anesthesia
Status: COMPLETED
Conditions: Pregnancy Related|Anesthesia|Oxygen Deficiency|Cesarean Section Complications
Interventions: DEVICE: Nasal high flow oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of a New and a Marketed Tablet Formulation Under Fasted and Fed Conditions in Healthy Adults
Status: WITHDRAWN
Conditions: Opioid-Related Disorders|Pain, Acute|Pain, Postoperative
Interventions: DRUG: Norco 5Mg-325Mg Tablet|DRUG: GRT7014 - Abuse Deterrent Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiochemotherapy With and Without Dose Escalation in Patients Presenting Locally Advanced or Inoperable Carcinoma of the Oesophagus
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: RADIATION: Conformal 3D Radiotherapy with " ENI "-type prophylactic irradiation of the lymph node|RADIATION: Boost|RADIATION: Boost|DRUG: chemotherapy: FOLFOX 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neutrophil Gelatinase-associated Lipocalin (NGAL) and Contrast Media Induced Nephropathy
Status: COMPLETED
Conditions: Contrast Media Induced Nephropathy (CIN)
Interventions: OTHER: application of intravenous volume|OTHER: oral fluid application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Losartan in Prevention of Radiation-Induced Heart Failure
Status: RECRUITING
Conditions: Breast Cancer|Myocardial Fibrosis|Radiation-Induced Fibrosis
Interventions: DRUG: Losartan|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cluster Randomized Trial of Stepped Care Intervention vs. Treatment as Usual for Patients With Depression
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Active monitoring|BEHAVIORAL: Bibliotherapy|BEHAVIORAL: Online self-help|BEHAVIORAL: Outpatient psychotherapy|PROCEDURE: Psychiatric treatment|BEHAVIORAL: Combined psychotherapy and psychopharmacological treatment|OTHER: Control group: treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HCV Reinfection in in HIV/HCV-coinfected Patients Achieving SVR by Antiviral Therapy
Status: UNKNOWN
Conditions: Hepatitis C Virus Infection|Hepatitis C Virus Infection, Response to Therapy of|Human Immunodeficiency Virus (HIV) Coinfection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prophylactic Administration of Natural Progesterone in the Prevention of Preterm Delivery in Twin Pregnancies
Status: COMPLETED
Conditions: Preterm Delivery
Interventions: DRUG: progesterone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Integration of Tai Chi and Repetitive Transcranial Magnetic Stimulation for Sleep Disturbance in Older Adults
Status: COMPLETED
Conditions: Sleep Disturbance
Interventions: BEHAVIORAL: Tai Chi|OTHER: repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study
Status: UNKNOWN
Conditions: Cardiovascular Events|Type2 Diabetes|Renal Disease
Interventions: DRUG: SGLT2 inhibitor|DRUG: DPP-4 inhibitor|DRUG: GLP-1RA|DRUG: 2nd generation SU
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lirilumab and Azacitidine in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Acute Biphenotypic Leukemia|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|BIOLOGICAL: Lirilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone Material Comparison in Maxillary Sinus Augmentation
Status: COMPLETED
Conditions: Alveolar Bone Resorption|Sequela|Tooth Extrusion
Interventions: BIOLOGICAL: Shefabone|BIOLOGICAL: Bio-Oss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Shortened Aggrastat® Versus Integrilin in Percutaneous Coronary Intervention
Status: COMPLETED
Conditions: Myocardial Infarction|Acute Coronary Syndromes|Unstable Angina
Interventions: DRUG: Short Tirofiban|DRUG: Eptifibatide|DRUG: Long Tirofiban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PD-1 Antibody (SHR-1210) Plus Capecitabine in Patients With Intrahepatic Cholangiocarcinoma After Surgery
Status: UNKNOWN
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: DRUG: PD-1 blocking antibody SHR-1210|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 19F MRI of Ventilation in Subjects With Cystic Fibrosis Undergoing Treatment for Pulmonary Exacerbation
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DEVICE: Lung Clearance Index|DRUG: MRI with PFP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Immunogenicity Study of Prophylactic Streptococcus Pneumoniae Vaccine
Status: COMPLETED
Conditions: Streptococcus Pneumoniae
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: GEN-004 Low Dose|BIOLOGICAL: GEN-004 Low Dose + Adjuvant|BIOLOGICAL: GEN-004 Mid Dose|BIOLOGICAL: GEN-004 Mid Dose + Adjuvant|BIOLOGICAL: GEN-004 High Dose|BIOLOGICAL: GEN-004 High Dose + Adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Postoperatory Analgesia After Total Knee Arthroplasty
Status: COMPLETED
Conditions: PAIN
Interventions: OTHER: Spinal anesthesia|OTHER: Femoral nerve block|OTHER: sciatic nerves block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Inducible Regulatory T Cells (iTregs) in Non-Myeloablative Sibling Donor Peripheral Blood Stem Cell Transplantation
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Acute Lymphocytic Leukemia|Chronic Myelogenous Leukemia|Non-Hodgkin Lymphoma|Hodgkin Lymphoma|Chronic Lymphocytic Leukemia|Multiple Myeloma|Myelodysplastic Syndrome
Interventions: BIOLOGICAL: iTreg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cadonilimab Combined With S-1 or Capecitabine as Second-line Treatment for Advanced Pancreatic Cancer
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Neoplasms
Interventions: DRUG: Cadonilimab+S-1or Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study on Umbilical Cord Milking to Prevent and Decrease the Severity of Anemia in Preterms
Status: COMPLETED
Conditions: Anemia
Interventions: PROCEDURE: umbilical cord milking|PROCEDURE: umbilical cord clamping immediately
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Chemokine Receptor 5 (CCR5) Inhibition on Sarcoidosis Immunophenotypes
Status: TERMINATED
Conditions: Sarcoidosis
Interventions: DRUG: all subjects will receive maraviroc 300mg orally twice a day for 6 weeks|PROCEDURE: Bronchoscopy with bronchoalveolar lavage|PROCEDURE: venipunctures|PROCEDURE: Skin biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Monitored Anesthesia Care Versus Intubated General Anesthesia for Open Heart Surgery Under Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Monitored Anesthesia Care|Cardiac Surgery|Postoperative Recovery
Interventions: DEVICE: Non-intubation and monitoring anesthesia care (MAC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Interleukin-1 Receptor Antagonist on Inhalation of 20,000 EU Clinical Ctr Reference Endotoxin in Normal Volunteers
Status: COMPLETED
Conditions: Healthy Control Subjects
Interventions: DRUG: Anakinra|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate the Safety and Efficacy of RAD1901 in Postmenopausal Women With Moderate to Severe Vasomotor Symptoms
Status: TERMINATED
Conditions: Vasomotor Symptoms|Hot Flashes
Interventions: DRUG: RAD1901|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of the Fascial Distortion Model on the Cervical Spine in Individuals With Temporomandibular Disorder
Status: RECRUITING
Conditions: Temporomandibular Disorder|Temporomandibular Disorders|Temporomandibular Joint Disorders|Temporomandibular Joint Dysfunction Syndrome|Temporomandibular Joint Dysfunction|Manual Therapy|Core Stabilization Exercise Therapy
Interventions: PROCEDURE: Fascial Distortion Model|PROCEDURE: Rocabado's 6x6 Exercises|BEHAVIORAL: Patient Education|PROCEDURE: Core Stabilization Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Healing Dynamics in Human Extraction Sockets Grafted With Bio-Oss Collagen®
Status: ACTIVE_NOT_RECRUITING
Conditions: Tooth Loss
Interventions: DEVICE: xenograft (BioOss Collagen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Mango Leaf Extract (Zynamite®) on Cognitive Function, Mood and Stress
Status: COMPLETED
Conditions: Cognitive Change|Stress
Interventions: DIETARY_SUPPLEMENT: Zynamite®|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Eczema Action Plan Improves Patient and Caregiver Understanding and Perception of Atopic Dermatitis Management
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: OTHER: A written Eczema Action Plan (EAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Repeated Instruction by Telephone on the Day Before Colonoscopy to Patients Undergoing Colonoscopy
Status: COMPLETED
Conditions: Ottawa Score|Adenoma
Interventions: OTHER: telephone education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Azithromycin Versus Erythromycin For Preterm Prelabor Rupture of Membranes
Status: NOT_YET_RECRUITING
Conditions: Preterm Premature Rupture of Membrane
Interventions: DRUG: Antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study on Postoperative Urinary and Sexual Function During Laparoscopic Functional Total Mesorectum Excision
Status: RECRUITING
Conditions: Rectal Cancer
Interventions: PROCEDURE: Laparoscopic FTME surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pegylated-Interferon and Ribavirin Plus Metformin in the Treatment of Chronic HCV Infection and Insulin Resistance
Status: UNKNOWN
Conditions: Chronic Hepatitis C|Insulin Resistance
Interventions: DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Further Acute Research of a Subcutaneous Implantable Defibrillator (S-ICD) System
Status: COMPLETED
Conditions: Ventricular Fibrillation|Ventricular Tachycardia
Interventions: DEVICE: Subcutaneous Implantable Defibrillator (S-ICD) system|DEVICE: ICD
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence Study of Tafolecimab Injections in Chinese Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy Male Subjects
Interventions: DRUG: tafolecimab (a modified manufacturing process)|DRUG: tafolecimab (a original manufacturing process)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Velaglucerase Alfa (Vpriv) on Skeletal Development in Pediatric Gaucher Disease
Status: WITHDRAWN
Conditions: Gaucher Disease Type 1|Gaucher Disease Type 3
Interventions: DRUG: Velaglucerase alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flare Type Self-expandable Metal Stent for Malignant Colorectal Obstruction
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DEVICE: Flare type stent|DEVICE: Conventional D-type stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Bioavailability of Liposomal and Traditional Formulation of Vitamin C
Status: COMPLETED
Conditions: Bioavailability of Vitamin C
Interventions: DIETARY_SUPPLEMENT: Liposomal Vitamin C|DIETARY_SUPPLEMENT: Traditional Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Sensori-motor Integration Training in Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing-remitting Multiple Sclerosis
Interventions: PROCEDURE: Sensory-motor Integration Training|PROCEDURE: Conventional neurorehabilitation treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Plant Stanols and Gene Expression Profile
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: control margarine|DIETARY_SUPPLEMENT: plant stanol-enriched margarine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Busulfan, Fludarabine Phosphate, and Post-Transplant Cyclophosphamide in Treating Patients With Blood Cancer Undergoing Donor Stem Cell Transplant
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|High Risk Acute Myeloid Leukemia|High Risk Myelodysplastic Syndrome|Lymphoproliferative Disorder|Myelodysplastic Syndrome|Myelodysplastic/Myeloproliferative Neoplasm|Recurrent Acute Lymphoblastic Leukemia|Recurrent Acute Myeloid Leukemia|Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Recurrent High Risk Myelodysplastic Syndrome|Recurrent Hodgkin Lymphoma|Recurrent Myelodysplastic Syndrome|Recurrent Non-Hodgkin Lymphoma|Recurrent Plasma Cell Myeloma
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Busulfan|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|DRUG: Mycophenolate Mofetil|OTHER: Pharmacological Study|DRUG: Tacrolimus|DRUG: Thiotepa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enteral Administration of Docosahexaenoic Acid to Prevent Retinopathy of Prematurity
Status: COMPLETED
Conditions: Retinopathy of Prematurity
Interventions: DIETARY_SUPPLEMENT: docosahexaenoic acid|DIETARY_SUPPLEMENT: sunflower oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of Pembrolizumab (MK-3475) in Combination With Investigational Agents for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98)
Status: ACTIVE_NOT_RECRUITING
Conditions: Small Cell Lung Carcinoma
Interventions: BIOLOGICAL: coformulation pembrolizumab/quavonlimab|DRUG: lenvatinib|BIOLOGICAL: MK-4830|BIOLOGICAL: coformulation favezelimab/pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Capecitabine With Fulvestrant for Postmenopausal Women With Hormone Receptor Positive Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: capecitabine|DRUG: fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lactobacillus Reuteri for the Treatment of Infantile Colic:
Status: COMPLETED
Conditions: Infantile Colic|Crying
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri (DSM 17938)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT