pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Bacteriophage Effects on Pseudomonas Aeruginosa
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: OTHER: Collection of induced sputum in order to evaluate the efficacy of a cocktail of 10 bacteriophages.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Short-term Pre-OPerative Durvalumab (MEDI 4736) in Early Small Triple Negative Breast Cancer Patients (POP-Durva)
Status: RECRUITING
Conditions: Early Small (cT1N0) Triple Negative Breast Cancer
Interventions: DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Belzutifan (MK-6482) as Monotherapy and in Combination With Lenvatinib (E7080/MK-7902) With or Without Pembrolizumab (MK-3475) in China Participants With Advanced Renal Cell Carcinoma (MK-6482-010)
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Belzutifan|BIOLOGICAL: Pembrolizumab|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Electroencephalography Guided General Anesthesia on Postoperative Delirium in Children
Status: NOT_YET_RECRUITING
Conditions: Postoperative Delirium|Postoperative Pain
Interventions: PROCEDURE: EEG guided general anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effects of Pain Neuroscience Education With Conventional Physical Therapy in Patients With Chronic Low Back Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Low-back Pain
Interventions: PROCEDURE: Pain neuroscience education|PROCEDURE: Standard Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes of Left Atrial Function and Quality of Life After Transcatheter Closure of Left Atrial Appendage in Patients With Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Left atrial appendage closure|PROCEDURE: Radiofrequency ablation|PROCEDURE: LAAC combined with radiofrequency ablation group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation and Evaluation of "Mindfulness-Based Cognitive Therapy" in a Health Care Region in Flanders: a Randomized Clinical Trial
Status: COMPLETED
Conditions: Recurrent Depression
Interventions: BEHAVIORAL: Mindfulness-Based Cognitive Therapy (MBCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET Imaging Study of Amish and Mennonite Patients With CNTNAP2 Mutations
Status: TERMINATED
Conditions: Schizophrenia
Interventions: RADIATION: PET/SPECT Scan|DEVICE: MRI scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: DAPAgliflozin for Renal Protection in Heart Transplant Recipients
Status: RECRUITING
Conditions: Heart Transplant Failure|Kidney Failure
Interventions: DRUG: Dapagliflozin 10 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Immunogenicity and Safety of Heterologous SARS-CoV-2 Vaccine Schemes
Status: COMPLETED
Conditions: COVID-19 Vaccines
Interventions: DRUG: Gam-COVID-Vac / Gam-COVID-Vac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intravenous Lidocaine for Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Postoperative Pain|Opioid Consumption
Interventions: DRUG: Lidocaine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Debated Role of Sleep Studies in Patients Under Established Home Mechanical Ventilation
Status: COMPLETED
Conditions: Hypoventilation Syndrome|Chronic Obstructive Pulmonary Disease|Obesity Hypoventilation Syndrome|Restrictive Lung Disease|Neuromuscular Diseases
Interventions: DIAGNOSTIC_TEST: Sleep studies under noninvasive ventilation therapy|DIAGNOSTIC_TEST: Routine tests
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dalfampridine and Gait in Spinocerebellar Ataxias
Status: COMPLETED
Conditions: Spinocerebellar Ataxias Type 1|Spinocerebellar Ataxias Type 2|Spinocerebellar Ataxias Type 3|Spinocerebellar Ataxias Type 6
Interventions: DRUG: Dalfampridine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: R-CHOP-B Bevacizumab for Diffuse Large B Cell Lymphoma
Status: TERMINATED
Conditions: Non-Hodgkin's Lymphoma|B-cell Lymphoma
Interventions: DRUG: bevacizumab, Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis
Status: UNKNOWN
Conditions: Osteoarthritis
Interventions: DRUG: Milnacipran|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: European Collaborative Multicenter Observational Study: Modular Treatment With PMMR and Targeted Compartmental Pelvic Lymphadenectomy Followed by Therapeutic Pelvic and Paraaortic Lymphadenectomy in Node Positive Disease for Locoregional Control in Endometrial Cancer FIGO Stages I-III
Status: RECRUITING
Conditions: Endometrial Cancer
Interventions: PROCEDURE: Peritoneal Mesometrial Resetion + Targeted Compartmental Lymphadenectomy (PMMR+TCL)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Ramucirumab (IMC-1121B) and Paclitaxel in Participants With Solid Tumors
Status: COMPLETED
Conditions: Malignant Solid Tumor
Interventions: BIOLOGICAL: ramucirumab (IMC-1121B)|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRD-guided Analgesia During FESS for Intraoperative Blood Loss
Status: UNKNOWN
Conditions: Endoscopic Sinus Surgery
Interventions: DRUG: Remifentanil|DEVICE: pupillary dilatation reflex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Decreasing the Incidence of Delirium After Cardiac Surgery
Status: WITHDRAWN
Conditions: C.Surgical Procedure; Cardiac|Delirium
Interventions: DRUG: Benzodiazepine|DRUG: Fentanyl|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hormone Therapy and OGX-011 Before Radical Prostatectomy in Treating Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: buserelin|DRUG: custirsen sodium|DRUG: flutamide|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigational Drug, Palbociclib (PD-0332991), Is Being Studied In Combination With Velcade And Dexamethasone In Patients With Multiple Myeloma. Patients Must Have Received Prior Treatment For Multiple Myeloma.
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib|DRUG: Dexamethasone|DRUG: PD 0332991
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Combination of Fenofibrate and Simvastatin Versus Pravastatin
Status: COMPLETED
Conditions: Hyperlipidemia
Interventions: DRUG: Fenofibrate/Simvastatin|DRUG: Fenofibrate/Simvastatin|DRUG: Pravastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Connect2Move: Valorization of Natural Cardio Trekking Hiking Trails
Status: UNKNOWN
Conditions: Cardiovascular Prevention|Healthy|Healthy Lifestyle
Interventions: OTHER: Measurement of cardiorespiratory performance in 3 different settings|OTHER: GENERAL CARDIO HIKES AS PART OF GENERAL TOURIST OFFER OF MUNICIPALITIES
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: NBT-NM108 as an Early Treatment for Suspected or Confirmed Symptomatic COVID-19 Patients
Status: COMPLETED
Conditions: Suspected or Confirmed COVID-19
Interventions: DRUG: NBT-NM108|OTHER: Usual Care Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Importance of Surgical Approach for Gynecological Surgery on Metabolic Effects and Subsequent Recovery
Status: UNKNOWN
Conditions: Insulin Resistance
Interventions: PROCEDURE: Abdominal hysterectomy|PROCEDURE: Robot assisted laparoscopic hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Pyronaridine-artesunate (Pyramax® or Artecom®)in COVID-19 Patients
Status: UNKNOWN
Conditions: Covid19
Interventions: DRUG: Artecom® (pyronaridine-artesunate)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Aromatherapy in Conjunction With Physical/Occupational Therapy in an Acute Care Setting
Status: ENROLLING_BY_INVITATION
Conditions: Suffering, Physical|Nausea
Interventions: DRUG: Lavender Oil|DRUG: Mandarin Oil|DRUG: Peppermint oil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Parathyroid Hormone (PTH) With Alendronate for Osteoporosis
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Parathyroid Hormone|DRUG: Alendronate|DRUG: Teriparatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conservative Interventions for Treating Clavicle Fractures in Adults
Status: UNKNOWN
Conditions: Fracture of Clavicle
Interventions: OTHER: a standard arm sling|OTHER: a figure-of-eight bandage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label Study to Evaluate the Long-term Safety and Tolerability of LUM001 in Patients With Primary Biliary Cirrhosis
Status: WITHDRAWN
Conditions: Primary Biliary Cirrhosis
Interventions: DRUG: LUM001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Individual and Group Occupational Therapy on General Self-Efficacy, Psychological Well-Being, Personal Independence and Occupational Therapy in Older Adults
Status: COMPLETED
Conditions: Individuality|Self-Efficacy|Well-being
Interventions: BEHAVIORAL: Individual Occupational Therapy|BEHAVIORAL: Group Occupational Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Electroacupuncture for Preventing Postoperative Delirium in Older Adults Undergoing Total Knee Arthroplasty
Status: NOT_YET_RECRUITING
Conditions: Postoperative Delirium
Interventions: DEVICE: Disposable acupuncture needles (0.30 × 75 mm)|DEVICE: Placebo needles (0.30 × 25 mm)|DEVICE: SDZ-V electroacupuncture devices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Paravertebral Block Versus Thoracic Epidural Analgesia
Status: COMPLETED
Conditions: Lung Cancer|Postoperative Pain
Interventions: DRUG: Thoracic epidural|DRUG: Paravertebral block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Cosmetic Benefit of a Skin Cream in Healthy Females With Mild to Advanced Photo-damaged Facial Skin Who Have Undergone a Glycolic Acid Facial Peel Procedure
Status: COMPLETED
Conditions: Skin Care
Interventions: OTHER: Cream (Test product)|OTHER: Cleanser (Reference Product)|OTHER: Sunscreen (Reference Product)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Constipation
Interventions: DRUG: Linaclotide|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Prophylactic Use of a Preoperative IABP in High-Risk Coronary Artery Bypass Graft Surgery
Status: COMPLETED
Conditions: Ischemic Cardiomyopathy|Heart Failure
Interventions: DEVICE: Intra-Aortic Ballon Pump insertion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Promoting Full Oral Feeding in Preterm Infants Less Than 30 Weeks Gestational Age
Status: COMPLETED
Conditions: Preterm Infants
Interventions: BEHAVIORAL: New Oral feeding process
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Denosumab vs Zoledronate After Vertebroplasty
Status: COMPLETED
Conditions: Denosumab Allergy|Zoledronic Acid Allergy
Interventions: DRUG: Denosumab Injection|DRUG: Zoledronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Bioceramic Materials for Bone Defects Repair
Status: RECRUITING
Conditions: Bone Lesion|Cartilage Degeneration|Osteo Arthritis Knee|Bone Fracture|Bone Injury|Bone Loss
Interventions: DEVICE: Commercial bone implant product Group|DEVICE: Mirco-structured Bioceramic Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Intra-Articular Injection of RegenoGel-OSP™(Self-Plasma) to Treat Pain Following Arthroscopic Surgery
Status: UNKNOWN
Conditions: Meniscal Tear
Interventions: DEVICE: RegenoGel-OSP™|OTHER: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Auditory and Tactile Stimuli in Traumatic Coma
Status: NOT_YET_RECRUITING
Conditions: Head Trauma|Traumatic Coma|Nursing Caries
Interventions: OTHER: Auditory stimulus|OTHER: Tactile stimulus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: The Effect of Negative Pressure Wound Therapy on Wound Healing in Major Amputations of the Lower Limb
Status: RECRUITING
Conditions: Negative-Pressure Wound Therapy|Amputation|Wound Heal
Interventions: DEVICE: PICO VAC|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Erector Spinae Plane Block Versus Paravertebral Block in Mastectomy
Status: WITHDRAWN
Conditions: Postoperative Pain
Interventions: PROCEDURE: Erector Spinae Plane Block|PROCEDURE: Paravertebral Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of a Probiotic Blend on Stress in Moderately Stressed Teens
Status: COMPLETED
Conditions: Stress
Interventions: DIETARY_SUPPLEMENT: Probiotic Blend|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SMOFlipid and Incidence of BPD in Preterm Infants
Status: RECRUITING
Conditions: Very Low Birth Weight Infant|Bronchopulmonary Dysplasia
Interventions: OTHER: n3-LCPUFA enriched Intravenous Lipid Emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Low Dose Tamoxifen With or Without Omega-3 Fatty Acids for Breast Cancer Risk Reduction
Status: NOT_YET_RECRUITING
Conditions: Breast Atypical Hyperplasia|Breast Carcinoma|Breast Ductal Carcinoma In Situ|Breast Lobular Carcinoma In Situ
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Mammography|DRUG: Omega-3-Acid Ethyl Esters|OTHER: Questionnaire Administration|PROCEDURE: Random Periareolar Fine-Needle Aspiration|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Creatine Treatment for Female Adolescents With Depression Who Are Non-Responders to Fluoxetine or Escitalopram
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Creatine Monohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Monitoring TECHNOlogies in the PERI-OPerative Care of Cardiac Surgical Patients
Status: COMPLETED
Conditions: C.Surgical Procedure; Cardiac|Right-Sided Heart Failure|Acute Kidney Injury|Respiratory Insufficiency|Postoperative Complications
Interventions: PROCEDURE: Cardiac surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Great Saphenous Vein Anatomy at the Proximal Medial Thigh as a Potential Site for Rescue Venous Access
Status: ENROLLING_BY_INVITATION
Conditions: Anatomy of the GSV for Rescue Peripheral IV Access
Interventions: DIAGNOSTIC_TEST: US ot the GSV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: DBS of the SCC for the Treatment of Medically Refractory CLBP
Status: RECRUITING
Conditions: Chronic Low-back Pain
Interventions: DEVICE: Deep Brain Stimulation of the Subgenus Cingulate Cortex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Manual Lymphatic Drainage and Kinesio Taping on Delayed Onset Muscle Soreness
Status: NOT_YET_RECRUITING
Conditions: Delayed Onset Muscle Soreness
Interventions: OTHER: kinesio taping|OTHER: placebo kinesio taping|OTHER: manual lymph drainage|OTHER: placebo manual lymph drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies
Status: RECRUITING
Conditions: Solid Tumor, Adult
Interventions: DRUG: KQB198|DRUG: osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxidative Stress and Nutritional Supplementation Intervention Study
Status: COMPLETED
Conditions: Oxidative Stress|Inflammation|Aging|Dementia|Pain
Interventions: DIETARY_SUPPLEMENT: secoisolariciresinol diglucoside
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Adenovirus + Pembrolizumab to Trigger Immune Virus Effects
Status: COMPLETED
Conditions: Brain Cancer|Brain Neoplasm|Glioma|Glioblastoma|Gliosarcoma|Malignant Brain Tumor|Neoplasm, Neuroepithelial|Neuroectodermal Tumors|Neoplasm by Histologic Type|Neoplasm, Nerve Tissue|Nervous System Diseases
Interventions: BIOLOGICAL: DNX-2401|BIOLOGICAL: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Therapy With an Alpha-lactalbumin Vaccine in Triple-Negative Breast Cancer
Status: RECRUITING
Conditions: Pathologic Stage IIA-IIIC Triple-Negative Breast Cancer|TNBC - Triple-Negative Breast Cancer|Residual Disease
Interventions: BIOLOGICAL: α-lactalbumin vaccine|BIOLOGICAL: Zymosan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Linked Color Imaging vs. White Light for Colorectal Dysplasia in Ulcerative Colitis
Status: UNKNOWN
Conditions: Ulcerative Colitis
Interventions: DEVICE: Linked Color Imaging|DEVICE: white light imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of the Safety and Effectiveness of Canagliflozin (JNJ-28431754) in Promoting Weight Loss in Overweight and Obese Patients Who do Not Have Diabetes
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Canagliflozin (JNJ-28431754)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Music Distraction and Its Influence on Anesthetic Requirements During Elective Knee Surgery
Status: COMPLETED
Conditions: Anesthesia; Functional|Surgery
Interventions: OTHER: Music|OTHER: Headphones|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Family Psychoeducation on Psychosis
Status: UNKNOWN
Conditions: Postpartum Psychosis
Interventions: BEHAVIORAL: drug compliance|BEHAVIORAL: Encouragement of drug compliance|BEHAVIORAL: Family psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Radioiodine-avid Bone Metastases From Thyroid Cancer Without Structural Abnormality
Status: UNKNOWN
Conditions: Bone Metastases|Thyroid Cancer
Interventions: OTHER: Administrative data|OTHER: Clinical data|OTHER: Histological data|OTHER: Imaging data|OTHER: Biological data|OTHER: Further treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Diet and Aggression: Reducing Aggression Among Chronic Psychiatric Inpatients Through Dietary Supplementation
Status: COMPLETED
Conditions: Psychiatric Hospitalization
Interventions: DIETARY_SUPPLEMENT: Orthica Soft Multi Mini and Orthica Fish EPA Mini
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Neuronavigated Continuous Theta Burst Stimulation of the Left Heschl's Gyrus in Chronic Tinnitus
Status: COMPLETED
Conditions: Chronic Tinnitus
Interventions: DEVICE: Left temporal verum cTBS|DEVICE: Left temporal placebo cTBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Inactivated Trivalent Influenza Vaccine on NSCLC Patients Receiving PD-1 / PD-L1 Inhibitors
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer|Influenza Vaccine
Interventions: DRUG: PD-1/PD-L1 inhibitors|BIOLOGICAL: Inactivated trivalent influenza vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Aminophylline Bolus Versus Infusion on Recovery Time in Patients Undergoing Lumbar Spine Surgery
Status: RECRUITING
Conditions: Anesthesia
Interventions: DRUG: Aminophylline bolus then infusion|DRUG: aminophylline bolus|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Estetrol Monohydrate (E4) on QTc Interval
Status: COMPLETED
Conditions: Prolonged QTc Interval
Interventions: DRUG: Estetrol 20 mg|DRUG: Estetrol 100 mg|DRUG: Placebo|DRUG: Moxifloxacin 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paracetamol / Ibuprofen for Postpartum Pain in the Early Postpartum Period
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Paracetamol 1000 mg|DRUG: Ibuprofen 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study Measuring the Safety, Immunogenicity and Lot Consistency of Cell Derived Influenza Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza Vaccine|BIOLOGICAL: Influenza Vaccine|BIOLOGICAL: Influenza Vaccine|BIOLOGICAL: Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: 1H Magnetic Resonance Spectroscopy in Migraine Patients
Status: COMPLETED
Conditions: Migraine Disorders|Migraine Without Aura|Headache Disorders, Primary|Headache Disorders|Brain Diseases|Central Nervous System Diseases|Nervous System Diseases
Interventions: DRUG: Glyceryl trinitrate (I.V. infusion 0.5 µg/kg/min over 20 min)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Rocuronium on the Acute Hypoxic Ventilatory Response in Patients With Obstructive Sleep Apnea
Status: COMPLETED
Conditions: OSA|Rocuronium|Neuromuscular Blockade|Hypoxic Ventilatory Response|CPAP
Interventions: DRUG: Rocuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Role of Vocal Rest After Removal of Benign Lesions From Vocal Cord
Status: COMPLETED
Conditions: Vocal Fold Polyp|Vocal Cord Dysfunction
Interventions: BEHAVIORAL: post operative voice rest|BEHAVIORAL: No voice rest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NEUROwave - Extracorporeal Shock Wave Therapy (ESWT) in Acute Traumatic Complete (AIS A) and Incomplete (AIS B-D) Cross-sectional Lesions on Motor and Sensory Function Within Six Months After Injury
Status: RECRUITING
Conditions: Acute Traumatic Spinal Cord Injury
Interventions: DEVICE: Shock waves|DEVICE: dummy head
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Femtosecond Laser Assisted Cataract Surgery in Intumescent Cataracts
Status: COMPLETED
Conditions: Intumescent Cataract
Interventions: DEVICE: Femtosecond laser|PROCEDURE: Continuous Curvilinear Capsulorhexis (CCC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploring the Effects of a High Chlorophyll Dietary Intervention to Reduce Colon Cancer Risk in Adults
Status: COMPLETED
Conditions: Colon Cancer Prevention
Interventions: BEHAVIORAL: High chlorophyll diet - intervention 1st|BEHAVIORAL: High chlorophyll diet - control 1st
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Use of a Mitochondrial Enhancement Treatment in Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Depression
Interventions: DRUG: acetyl-l-carnitine PLUS alpha-lipoic acide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC: ERCC1 Biomarker Enrichment and Interaction Design
Status: RECRUITING
Conditions: Squamous Cell Carcinoma
Interventions: DRUG: Cisplatin|RADIATION: IMRT|DRUG: Docetaxel|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing Identity: An Eating Disorder Randomized Clinical Trial
Status: COMPLETED
Conditions: Anorexia Nervosa|Bulimia Nervosa
Interventions: BEHAVIORAL: Identity Intervention Program|BEHAVIORAL: Supportive Psychotherapy for the Eating Disorders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Moxidectin for LF, Cote d'Ivoire (DOLF)
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphatic Filariasis
Interventions: DRUG: Ivermectin|DRUG: Diethylcarbamazine|DRUG: Albendazole|DRUG: Moxidectin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online Treatments for Mood and Anxiety Disorders in Primary Care
Status: COMPLETED
Conditions: Depression|Generalized Anxiety Disorder|Panic Disorder
Interventions: BEHAVIORAL: CCBT+ISG/Collaborative Care|BEHAVIORAL: CCBT/Collaborative Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Botulinum Toxin Type A for Moderate to Severe Crow's Feet Lines
Status: COMPLETED
Conditions: Skin Aging
Interventions: DRUG: Botulinum Toxin Type A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Text Messaging to Improve Adherence to Web-Based Cessation Treatment
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Personalization|BEHAVIORAL: Integration|BEHAVIORAL: Dynamic Tailoring|BEHAVIORAL: Message Intensity|BEHAVIORAL: Optimal-Adherence Text
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Carbon Monoxide to Prevent Lung Inflammation
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Adult
Interventions: PROCEDURE: Bronchoscopy|PROCEDURE: Bronchoalveolar lavage|DRUG: Endotoxin|DRUG: Carbon Monoxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The MONARCA Project (MONitoring, treAtment and pRediCtion of bipolAr Disorder Episodes)
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DEVICE: MONARCA|DEVICE: NON-MONARCA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retroflexion In The Ascending Colon Is A Costless Endoscopic Maneuver Increasing Adenoma Detection Rate
Status: COMPLETED
Conditions: Colonoscopy|Adenoma Detection Rate|Adenoma Miss Rate|Retroflexion
Interventions: PROCEDURE: Retroflexion in the Right Colon
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Coadministration of GA2 Sporozoites With Adjuvants
Status: RECRUITING
Conditions: Malaria,Falciparum
Interventions: BIOLOGICAL: GA2|BIOLOGICAL: BCG|BIOLOGICAL: YF-17D (fractional ID dose)|DRUG: Imiquimod|OTHER: Mock immunization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Food Intake REstriction for Health OUtcome Support and Education (FIREHOUSE) Trial
Status: COMPLETED
Conditions: Lung Injury|Particulate Matter Inhalation Injury
Interventions: DIETARY_SUPPLEMENT: Low-Calorie Mediterranean Diet|COMBINATION_PRODUCT: Technology based monitoring and behavioral participation|OTHER: Usual care group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Viral Load Guided Immunosuppression After Lung Transplantation
Status: ACTIVE_NOT_RECRUITING
Conditions: Transplantation Lung
Interventions: OTHER: Tailored tacrolimus dosing|OTHER: Conventional tacrolimus dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Fiber Composite-enriched Breads on Glycemic Responses
Status: COMPLETED
Conditions: Glycemic Response
Interventions: OTHER: Wholegrain bread|OTHER: White bread|OTHER: 15% fiber-rich bread|OTHER: 30% fiber-rich bread
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamics of JNJ-64179375 in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-64179375|DRUG: Placebo|DRUG: 4 Factor Prothrombin Complex Concentrate (PCC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study in Mild Asthmatic Patients
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: GSK2190915 - 100mcg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial With Subcutaneous Immunotherapy in Patients Sensitized to Phleum Pratense
Status: COMPLETED
Conditions: Allergic Rhinoconjunctivitis
Interventions: BIOLOGICAL: Allergovac Depot|BIOLOGICAL: Allergovac Depot|BIOLOGICAL: Allergovac Depot|BIOLOGICAL: Allergovac Depot|BIOLOGICAL: Allergovac Depot|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of High Dose Naloxone on Secondary Hyperalgesia
Status: COMPLETED
Conditions: Hyperalgesia|Pain|Naloxone|Opioid Antagonist
Interventions: DRUG: Naloxone (2 mg/kg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effectiveness of Engagement-based Personalization of a Digital Mental Health Intervention
Status: COMPLETED
Conditions: Well-being
Interventions: BEHAVIORAL: personalized 2-week mobile wellbeing intervention|BEHAVIORAL: non-personalized 2-week mobile wellbeing intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effects of Botulinum Toxin on Oral Aperture in Patients With Scleroderma
Status: COMPLETED
Conditions: Scleroderma
Interventions: BIOLOGICAL: Botulinum toxin(Botox)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect and Mechanism of MMP-9 in Inducing Atherosclerosis
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DIAGNOSTIC_TEST: diagnosed as type 2 diabetes without atherosclerosis|DIAGNOSTIC_TEST: diagnosed as type 2 diabetes with atherosclerosis|DIAGNOSTIC_TEST: people without type 2 diabetes or atherosclerosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Enhancing Antiepileptic Drug Adherence
Status: COMPLETED
Conditions: Epilepsy
Interventions: BEHAVIORAL: Motivational Interviewing (MI)|BEHAVIORAL: Routine counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Treatment With Octreotide in Patients With Lymphangioleiomyomatosis
Status: COMPLETED
Conditions: Lymphangioleiomyomatosis|Lymphangiomyomas|Pleural Effusions|Ascites
Interventions: DRUG: Octreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CHARITÉ™ Artificial Disc Compared to Anterior Interbody Fusion for Treatment of Degenerative Disc Disease
Status: COMPLETED
Conditions: Degenerative Disc Disease
Interventions: DEVICE: CHARITÉ Artificial Disc|DEVICE: Anterior Interbody Fusion with BAK Cage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Different Automated External Defibrillation (AED) Training Methods
Status: UNKNOWN
Conditions: Improvement of BLS/AED Training Programmes
Interventions: OTHER: Different self-training methods|OTHER: Standard training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Maintenance Treatment of Toripalimab(JS001) in Patients With Unresectable Locally Advanced or Metastatic Mucosal Melanoma
Status: UNKNOWN
Conditions: Mucosal Melanoma
Interventions: DRUG: Toripalimab|DRUG: chemotherapy in combination with Endostar
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-Use Negative Pressure Wound Therapy System vs. Traditional Negative Pressure Wound Therapy System (tNPWT)
Status: COMPLETED
Conditions: Venous Leg Ulcers|Diabetic Foot Ulcers
Interventions: DEVICE: PICO System|DEVICE: tNPWT System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Randomized Controlled Trial Comparing Fat-free Versus Balanced (WHO) Diet in Gallstone Disease
Status: RECRUITING
Conditions: Gallstone Disease|Gallstone; Colic|Gallstone; Cholecystitis, Acute|Cholelithiases|Postcholecystectomy Syndrome|Dietary Habits
Interventions: OTHER: Fat-free diet|OTHER: Balanced WHO diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Pediatric ACEs Screening and Resiliency Study
Status: COMPLETED
Conditions: Fibrinogen Abnormality|Telomere Length, Mean Leukocyte|Atopic|Acute Infection|Inflammatory Response|Self-regulation
Interventions: BEHAVIORAL: Care Coordination|BEHAVIORAL: Resiliency Clinic|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study of EDP-938 in Non-hospitalized Adults With RSV Who Are at High Risk for Complications.
Status: RECRUITING
Conditions: RSV Infection
Interventions: DRUG: EDP-938|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Alfa-Adrenergic Receptor Blockade on Insulin-Stimulated Forearm Glucose Uptake and Metabolism in Chronic Heart Failure
Status: UNKNOWN
Conditions: Heart Failure, Congestive
Interventions: DRUG: phentolamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Comparative Study of Ceftaroline vs. Ceftriaxone in Adults With Community-Acquired Pneumonia
Status: COMPLETED
Conditions: Bacterial Pneumonia
Interventions: DRUG: Ceftaroline fosamil for Injection|DRUG: Ceftriaxone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Urolithin A (Mitopure) on Mitochondrial Quality in Muscle of Frail Older Adults
Status: RECRUITING
Conditions: Frailty|Sarcopenia|Aging|Muscle Atrophy
Interventions: DIETARY_SUPPLEMENT: Mitopure (Urolithin A)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Seasonal Malaria Chemoprevention With Dihydroartemisin Piperaquin vs. Sulfadoxine-pyrimethamin+Amodiaquin
Status: ACTIVE_NOT_RECRUITING
Conditions: Malaria,Falciparum
Interventions: DRUG: Sulfadoxine pyrimethamine + Amodiaquin|DRUG: Dihydroartemisinin piperaquin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: TB-IRIS NSAID Cox-2 Inhibitor Prevention Trial
Status: UNKNOWN
Conditions: Tuberculosis
Interventions: DRUG: Meloxicam 7.5mg daily for 8 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Blinatumomab in Japanese Patients With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Relapsed Refractory B Precursor Acute Lymphoblastic Leukemia
Interventions: DRUG: Blinatumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure
Status: RECRUITING
Conditions: Obesity|Normal Physiology|Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: +200% of dietary requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat|DIETARY_SUPPLEMENT: fasting|DIETARY_SUPPLEMENT: -50% of energy balance requirements. 50% of calories from carbohydrates, 20% from protein, and 30% from fat|DIETARY_SUPPLEMENT: +150% of energy balance requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat|DIETARY_SUPPLEMENT: +200% of dietary requirements, 51% of the calories from carbohydrates, 46%, from fat and 3% from protein|DIETARY_SUPPLEMENT: -25% of energy balance requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat|DIETARY_SUPPLEMENT: +150% of dietary requirements, 51% of the calories from carbohydrates, 46%, from fat and 3% from protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Improving Pain and Reducing Opioid Use (IPaRO) in Lumbar Spine Surgery Patients
Status: COMPLETED
Conditions: Lumbar Spinal Stenosis|Lumbar Spinal Instability|Lumbar Spine Degeneration
Interventions: DRUG: Standard analgesia use [Oxygen]|DRUG: Standard analgesia use [Hydromorphone]|DRUG: Standard analgesia use [Volatile Anesthesia]|DRUG: Standard analgesia use [Fentanyl]|DRUG: Multi-modal pain management [Acetaminophen + Gabapentin]|DRUG: Multi-modal pain management [Fentanyl]|DRUG: Multi-modal pain management [Intravenous Ketamine]|DRUG: Multi-modal pain management [Valium + Gabapentin]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Nutrients Supplementation in Antidepressant Treated Depressive Disorder Patients
Status: UNKNOWN
Conditions: Depressive Disorder, Major
Interventions: DIETARY_SUPPLEMENT: LF/Erinacine A-enriched Hericium/Plain chocolate + antidepressant(s)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Spinal Stimulation to Restore Hand Function in Children With Spinal Cord Injury
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injury Cervical
Interventions: DEVICE: Activity based upper extremity training with and without stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Tourniquet Use on Muscle Thigh Function.
Status: UNKNOWN
Conditions: Pneumatic Tourniquet|Muscle Weakness
Interventions: DEVICE: Pneumatic tourniquet use
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Multicenter Withdrawal Clinical Trials of N-acetyl Glucosamine Capsule for IBS-D Treatment
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: N-acetyl-D-glucosamine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Home-based Aerobic and Strength Exercises During Chemotherapy for Early Breast Cancer on Biomarkers of Aging
Status: RECRUITING
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Engagement in Physical Activity|OTHER: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION