pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Randomized Controlled Open Label Trial of Peg Alpha 2a Interferon and Adjusted-dose of Ribavirin vs. Standard Therapy in the Treatment of Naive Chronic Hepatitis C Patients Infected With Genotype 4
Status: COMPLETED
Conditions: Chronic Hepatitis C Virus
Interventions: DRUG: Pegylated interferon alpha-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Picosecond, Neodymium-doped Yttrium Aluminum Garnet Laser Therapy Using 1,064 nm and 595 nm
Status: COMPLETED
Conditions: Melasma
Interventions: DEVICE: PICO+4|DRUG: Neoquine Cream 2%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-blind, Placebo-controlled, Dose Response Study of AMG 162 (Denosumab) in Japanese Postmenopausal Osteoporotic Subjects
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: 100 mg AMG 162|DRUG: 60 mg AMG 162|DRUG: 14 mg AMG 162|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Salt Sensitivity, Cardiovascular and Metabolic Disease
Status: COMPLETED
Conditions: Cardiovascular Diseases|Heart Diseases|Hypertension|Angina Pectoris|Cerebrovascular Accident|Myocardial Infarction|Diabetes Mellitus|Heart Failure, Congestive|Heart Failure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Single And Multiple-visit Endodontic Retreatment Outcome.
Status: UNKNOWN
Conditions: Apical Periodontitis
Interventions: PROCEDURE: Non surgical Single visit Retreatment|PROCEDURE: Multi visit Retreatment with calcium hydroxide dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Tasimelteon for Treatment of Non-24-Hour-Sleep-Wake Disorder in Blind Individuals With No Light Perception
Status: ACTIVE_NOT_RECRUITING
Conditions: Non 24 Hour Sleep Wake Disorder
Interventions: DRUG: tasimelteon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Effectiveness Ex-Press Surgery Modification
Status: COMPLETED
Conditions: Glaucoma, Open-Angle|Glaucoma Secondary|Glaucoma, Primary Open Angle
Interventions: PROCEDURE: phacoemulsification with implantation of the Ex-Press|PROCEDURE: deep sclerectomy, phacoemulsification, ExPress implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety of Pomalidomide in Combination With Dexamethasone (Low Dose) in Patients With Refractory or Relapsed and Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of 5-fluorouracil (5-FU) in Patients With Metastatic Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Biweekly 5-FLUOROURACIL (5-FU)|DRUG: Biweekly Modified FOLFOX6|DRUG: Biweekly FOLFIRI|DRUG: mFOLFOXIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib and Topotecan in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Lung Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: bortezomib|DRUG: topotecan hydrochloride|OTHER: flow cytometry|OTHER: immunoenzyme technique|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between 4 Different Nasal Dilators
Status: TERMINATED
Conditions: Incompetence of Nasal Valve
Interventions: DEVICE: Nasal dilator Nasanita|DEVICE: Nasal dilator Nozovent|DEVICE: Nasal dilator Breath Right|DEVICE: Nasal dilator Airmax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Nasal High Frequency Oscillation for Respiratory Distress Syndrome in Twins Infants
Status: RECRUITING
Conditions: Nasal High Frequency Oscillation Ventilation
Interventions: DEVICE: noninvasive high-frequency ventilation (nHFOV)|DEVICE: nasal continuous positive airway pressure (nCPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Controlled, Open-label, Multicenter Clinical Trial Comparing the Efficacy and Safety of a Precision Treatment Regimen Based on Clinical-molecular Phenotypes With a Conventional Treatment Regimen in the Treatment of Patients With Active Takayasu's Arteritis
Status: RECRUITING
Conditions: Takayasu Arteritis
Interventions: DRUG: Prednisone|DRUG: Methotrexate|DRUG: Cyclophosphamid|DRUG: Tocilizumab|DRUG: Tofacitinib|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed Disodium and Bevacizumab in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: pemetrexed disodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Dose Study of MYK-461 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Placebo|DRUG: MYK-461
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomised, Single Centre, Double-Blind, Two-Period Crossover, Glucose Clamp Trial
Status: COMPLETED
Conditions: Diabetes, Type I
Interventions: DRUG: Levemir|DRUG: Humalog NPL Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PAL to Improve Oral Feeding for Infants With Chronic Lung Disease
Status: RECRUITING
Conditions: Chronic Lung Disease of Prematurity|Respiratory Distress Syndrome in Premature Infant|Bronchopulmonary Dysplasia|Preterm Birth
Interventions: DEVICE: Pacifier Activated Lullaby ®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CERE-110 in Subjects With Mild to Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: GENETIC: CERE-110: Adeno-Associated Virus Delivery of NGF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Marine n-3 Polyunsaturated Fatty Acids in Pre- and Postmenopausal Women
Status: COMPLETED
Conditions: Postmenopause|Premenopause
Interventions: DIETARY_SUPPLEMENT: marine n-3 polyunsaturated fatty acids|DIETARY_SUPPLEMENT: thistle oil|DIETARY_SUPPLEMENT: marine n-3 polyunsaturated fatty acids|DIETARY_SUPPLEMENT: Thistle oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Guselkumab Versus Placebo for the Treatment of Low Body Surface Area Moderate Plaque Psoriasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Moderate Plaque Psoriasis
Interventions: DRUG: Guselkumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Adolescent Pregnancy Prevention Program; Relationship Smarts+ With Lessons From Mind Matters
Status: RECRUITING
Conditions: Teen Pregnancy|Contraception Behavior|Sexually Transmitted Diseases|Reproductive Health|Sexual Risk Behavior
Interventions: BEHAVIORAL: Relationship Smarts Plus & Mind Matters|BEHAVIORAL: Relationship Smarts Plus alone|BEHAVIORAL: Preparing Adolescents for Young Adulthood (PAYA).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects on Cardiovascular Risk Factors of the Endogenous Hydroxytyrosol Generation After the Combined Intake of Wine and Tyrosol in Humans
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: OTHER: white wine|DIETARY_SUPPLEMENT: tyrosol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Management Of The Infusion-Associated Reactions In RRMS Patients Treated With LEMTRADA
Status: COMPLETED
Conditions: Relapsing-remitting Multiple Sclerosis
Interventions: DRUG: Alemtuzumab GZ402673|DRUG: cetirizine|DRUG: ranitidine|DRUG: methylprednisolone|DRUG: methylprednisolone|DRUG: aciclovir|DRUG: esomeprazole|DRUG: ibuprofen|DRUG: paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of PeakATP on Mood, Reaction Time and Cognition
Status: COMPLETED
Conditions: Cognitive Change|Mood
Interventions: DIETARY_SUPPLEMENT: PeakATP|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Cervicovaginal Immune Responses to 3 Deltoid or Thigh Intramuscular (IM) TicoVac
Status: COMPLETED
Conditions: Tick-Borne Encephalitis
Interventions: DRUG: TicoVac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of PEP on Oxygen Saturation and Carbon Dioxide After Abdominal Surgery
Status: COMPLETED
Conditions: Blood Gas Monitoring, Transcutaneous
Interventions: DEVICE: positive expiratory pressure (PEP)|DEVICE: Placebo comparator, Deep inspiration and expression in a placebo tube without resistance|OTHER: Deep breathing maneuvers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Correcting Public Misperceptions About Very Low Nicotine Content Cigarettes
Status: COMPLETED
Conditions: Tobacco Use, Cigarette Use
Interventions: BEHAVIORAL: Emotion-based messages about the harm of VLNC|BEHAVIORAL: Continued-harm-framed messages about the harm of VLNC|BEHAVIORAL: Myth-refuting messages about the harm of VLNC|BEHAVIORAL: Control messages about littering
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of HPV Vaccination on Recurrence Rates in HIV Patients With Condylomata
Status: COMPLETED
Conditions: HIV Positive|Anal Condylomata|Anal Warts|HIV Infections
Interventions: DRUG: Saline|DRUG: Quadrivalent Human Papillomavirus (Types 6,11,16,18) Recombinant Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: the Effect of Dexmedetomidine and Licodaine on Acute Postoperative Pain in Gynecological Laparoscopy
Status: WITHDRAWN
Conditions: Gynecologic Disease
Interventions: DRUG: Dexmedetomidine Hydrochloride|DRUG: Remifentanil Hydrochloride|DRUG: Lidocaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Flapless Emdogain in the Treatment of Periodontal Residual Pockets
Status: COMPLETED
Conditions: Chronic Periodontitis, Generalized
Interventions: PROCEDURE: Re-instrumentation with flapless Emdogain application|PROCEDURE: Re-instrumentation with placebo application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison Study of Patient Controlled Epidural Analgesia (PCEA) With and Without Basal Infusion Using Ropivacaine 0,15% and Fentanyl μg/ml for Pain Relief in Labor, Assessment of Efficacy and Maternal Satisfaction.
Status: COMPLETED
Conditions: Labor Pain
Interventions: OTHER: PCEA with basal infusion and demand dose using ropivacaine 0,15% and fentanyl 2μg/ml for pain relief in labor|OTHER: PCEA without basal infusion (demand only) using ropivacaine 0,15% and fentanyl 2μg/ml for pain relief in labor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Identification of IBS Metabotypes Based on Physiological Responses to Food
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: FODMAP|DIETARY_SUPPLEMENT: Gluten|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Footwear Generated Biomechanical Manipulation on Symptoms of Stress Urinary Incontinence
Status: COMPLETED
Conditions: Pelvic Floor Disorders|Stress Urinary Incontinence
Interventions: DEVICE: Footwear Generated Bio-Mechanical Manipulation (using shoes with pertupods) along with Traditional Pelvic Floor Therapy|OTHER: Traditional Pelvic Floor Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Visuospatial Attention, Eye Movements and Instrumental Activities of Daily Living (IADLs) in Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer's Disease
Interventions: PROCEDURE: visual search performance of everyday objects in realistic scenes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Find a Safe and Effective Dose of BI 905711 in Patients With Advanced Gastrointestinal Cancer
Status: COMPLETED
Conditions: Gastrointestinal Neoplasms|Cholangiocarcinoma|Pancreatic Neoplasms
Interventions: DRUG: BI 905711
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Controlled Trial With Hybrid Fractional Laser
Status: COMPLETED
Conditions: Vaginal Atrophy, Sexual Dysfunction, Vaginal Dryness, Dyspareunia
Interventions: DEVICE: Hybrid Fractional Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Bone Marrow Aspirate Concentrate in Patients Undergoing Meniscectomy
Status: RECRUITING
Conditions: Osteoarthritis Post-meniscectomy
Interventions: BIOLOGICAL: Bone Marrow Aspirate Concentrate|PROCEDURE: Standard Meniscectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of the Combined Treatment of Liposomed Polyphenols With G04CB02 on the ALS Patients
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DIETARY_SUPPLEMENT: Liposomed polyphenols resveratrol and curcumin|OTHER: Placebo for liposomed resveratrol and curcumin|DIETARY_SUPPLEMENT: Isocaloric Diet|DRUG: G04CB02|OTHER: Placebo microcrystalline methylcellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Measurement and Comparison of the Occlusive and Hydrating Capacity of Three Silicone Gels and One Gel Cream
Status: COMPLETED
Conditions: Scar Tissue or Healthy Skin
Interventions: DRUG: Dermatix|DRUG: Kelocote|DRUG: BAP scar gel|DRUG: Alhydran|DRUG: Bap Scar Care T|DRUG: Bap Scar Care S|DRUG: Mepiform|DRUG: Scar Ban Elastic
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Time of Positive Pressure Ventilation in Non-vigorous Infants Born Through Meconium-stained Amniotic Fluid
Status: COMPLETED
Conditions: Meconium Aspiration Syndrome|Infant, Newborn, Disease|Neonatal Resuscitation
Interventions: PROCEDURE: Endotracheal suctioning|PROCEDURE: No endotracheal suctioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diacerin for the Treatment of Epidermolysis Bullosa Simplex
Status: UNKNOWN
Conditions: Epidermolysis Bullosa Simplex
Interventions: DRUG: Diacerin cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Durvalumab and Vigil in Advanced Women's Cancers
Status: COMPLETED
Conditions: Breast Cancer|Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Carcinoma|Uterine Cancer|Cervical Cancer|Endometrial Cancer
Interventions: BIOLOGICAL: Vigil|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of BIIL 284 BS in Adult and Pediatric Cystic Fibrosis (CF) Patients
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: BIIL 284 BS, high dose|DRUG: BIIL 284 BS, low dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab in Metastatic HER2-negative Breast Cancer Patients With APOBEC3B Mutation
Status: UNKNOWN
Conditions: HER2-Negative Breast Cancer
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Myomectomy Followed by Oral Myfembree Versus Standard of Care Trial (SOUL)
Status: RECRUITING
Conditions: Metrorrhagia|Pelvic Pain|Menorrhagia|Leiomyoma
Interventions: DRUG: Myfembree Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of the SONA Saliva C-19 Rapid Self-Test for the Detection of COVID-19
Status: COMPLETED
Conditions: Sars-CoV-2 Infection
Interventions: DIAGNOSTIC_TEST: Sona Saliva C-19 Rapid Self-test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treatment of ACuTe Coronary Syndromes With Low-dose colchICine
Status: NOT_YET_RECRUITING
Conditions: Acute Coronary Syndrome|Unstable Angina|ST Elevation Myocardial Infarction|Non ST Segment Elevation Myocardial Infarction|Colchicine
Interventions: DRUG: Colchicine Pill|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Single Dose TenoMiR as a Treatment for Tennis Elbow
Status: COMPLETED
Conditions: Tennis Elbow
Interventions: DRUG: TenoMiR (Low Dose)|DRUG: TenoMiR (Medium Dose)|DRUG: TenoMiR (High Dose)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Versus Double Kirschner Wires for Intramedullary Fixation of Metacarpal V Fractures
Status: COMPLETED
Conditions: Fracture of Metacarpal Bone
Interventions: DEVICE: Single Kirschner Wire|DEVICE: Double Kirschner Wire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Suicide Risk Interventions
Status: NOT_YET_RECRUITING
Conditions: Suicide
Interventions: BEHAVIORAL: Enhanced Crisis Response Planning (ECRP)|BEHAVIORAL: Brief Cognitive Behavioral Therapy for Suicide Prevention (BCBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Skin Appearance and Quality of Life in Breast Cancer Survivors on Aromatase Inhibitor Therapy
Status: RECRUITING
Conditions: Anatomic Stage 0 Breast Cancer AJCC v8|Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Breast Adenocarcinoma|Estrogen Receptor-Positive Breast Carcinoma|Progesterone Receptor-Positive Breast Carcinoma
Interventions: OTHER: Non-Interventional Study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Patients Undergoing Primary Unilateral Elective Total Knee or Hip Replacement With Dabigatran Etexilate
Status: COMPLETED
Conditions: Arthroplasty, Replacement|Prevention of Venous Thromboembolism|Moderate Renal Impairment (CrCl 30-50 mL/Min)
Interventions: DRUG: Dabigatran etexilate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Characterization of 24 Hour Spirometry Profiles of Inhaled BI 1744 CL and Inhaled Tiotropium Bromide in Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Olodaterol (BI1744) Low|DRUG: Placebo (for olodaterol BI1744)|DRUG: Placebo (for Tiotropium)|DRUG: Olodaterol (BI1744) High|DRUG: Tiotropium 18 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Nebulized Analgesia for Laparoscopic Appendectomy Trial
Status: UNKNOWN
Conditions: Appendicitis
Interventions: DRUG: Ropivacaine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of the Use of Intensity Modulated Radiotherapy (IMRT) in Cancer of the Thyroid, Larynx and Hypopharynx
Status: COMPLETED
Conditions: Locally Advanced Larynx, Hypopharyngeal Squamous Cell Cancers|Locally Advanced Thyroid Cancers
Interventions: RADIATION: Dose-escalated radiotherapy level 1|RADIATION: Sequential dose-escalated radiotherapy level 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Prophylactic Administration of Oxytocin in Uniject™ on Postpartum Hemorrhage at Home Births in Ghana
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: OTHER: Oxytocin in Uniject
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sensory-cognitive and Physical Fitness Training in Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment (MCI)|Mild Alzheimer's Disease
Interventions: OTHER: auditory discrimination training|OTHER: physical movement training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine vs. Remifentanil for Pre-eclampsia During Caesarean Delivery
Status: COMPLETED
Conditions: Pregnancy|Severe Pre-eclampsia
Interventions: DRUG: Remifentanil|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Longitudinal Study of Oscillatory Positive Expiratory Pressure (oPEP) in Stable COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: Oscillating Positive Expiratory Pressure (Aerobika ®)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Pharmacokinetics of Oral Doses of EPX-100 in Healthy Subjects.
Status: COMPLETED
Conditions: Dravet Syndrome
Interventions: DRUG: EPX-100 (Clemizole Hydrochloride)|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Hyoscine N Butyl Bromide in Active Management of Labor
Status: COMPLETED
Conditions: Labor Fast
Interventions: DRUG: hyoscine-N-butyl bromide(HBB)|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Blood-saving Effect of Combined Intravenous Tranexamic Acid With Topical Floseal® Application Total Hip Arthroplasty
Status: UNKNOWN
Conditions: Hip Replacement, Total
Interventions: DRUG: intravenous application of tranexamic acid|DRUG: Floseal hemostatic matrix|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug and Non-Drug Treatment Of Severe Migraine
Status: COMPLETED
Conditions: Migraine Headache
Interventions: DRUG: Propranolol or nadolol|DRUG: Placebo control|BEHAVIORAL: Behavioral Migraine Management (BMM)|DRUG: Optimal Acute Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quality-of-life Impact of Newly Formed Digitalized Printed Paper Inserted Into Eyeglasses
Status: RECRUITING
Conditions: Orbital Deformity
Interventions: DEVICE: Digitalized printed paper|DEVICE: Traditional drawing image|OTHER: Healthy controls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gluconeogenesis in Very Low Birth Weight Infants Who Are Receiving Nutrition By Intravenous Infusion
Status: UNKNOWN
Conditions: Infant, Low Birth Weight|Hyperglycemia
Interventions: DRUG: alanine|DRUG: amino acids|DRUG: glucagon|DRUG: glucose|DRUG: glutamine|DRUG: glycerol|DRUG: insulin|DRUG: leucine|DRUG: lipids|DRUG: urea
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Efficacy of an Oral Probiotic Associated With a Fixed Combination of Benzoyl Peroxide and Adapalene in the Treatment of Acne
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DIETARY_SUPPLEMENT: Probiac|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-operative Administration of Sorafenib in Patients With Metastatic Renal Cell Carcinoma Undergoing Kidney Removal
Status: COMPLETED
Conditions: Renal Cell Carcinoma|Metastatic Disease
Interventions: DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype
Status: RECRUITING
Conditions: Asthma
Interventions: BIOLOGICAL: GSK3511294 (Depemokimab)|BIOLOGICAL: Mepolizumab|BIOLOGICAL: Benralizumab|BIOLOGICAL: Placebo|DRUG: Standard of care (SoC)|DEVICE: Pre-filled Syringes (PFS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)
Status: RECRUITING
Conditions: Kidney Failure, Chronic|Hyperphosphatemia
Interventions: DRUG: Liberal phosphate target|DRUG: Intensive phosphate target
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Reducing Nucleotide Exposure on Bone Health (ReNew)
Status: WITHDRAWN
Conditions: HIV/AIDS|HIV-1-infection|Osteopenia
Interventions: DRUG: Dolutegravir (DTG) 50MG/lamivudine (3TC) 300MG FIXED DOSE COMBINATION (FDC)|DRUG: Current tenofovir alafenamide (TAF)-containing ART regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LEADing Dementia End-of-Life Planning Conversations
Status: RECRUITING
Conditions: Alzheimer Disease|Mild Cognitive Impairment
Interventions: OTHER: LEADing Dementia End-of-Life Planning Conversations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Multi-center, Single-arm Trial Exploring the Safety and Clinical Effectiveness of RBX2660 Administered by Colonoscopy to Adults With Recurrent Clostridioides Difficile Infection
Status: ACTIVE_NOT_RECRUITING
Conditions: Clostridium Difficile Infection Recurrence
Interventions: DRUG: RBX2660
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0014 Combination Chemotherapy Plus Rituximab and Radiation Therapy in Treating Patients With Stage I or Stage II Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: prednisone|DRUG: vincristine sulfate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Age Versus Ovarian Reserve Markers Based Therapy in IVF (IVF)/Intracytoplasmic Sperm Injection (ICSI) Cycles
Status: TERMINATED
Conditions: In Vitro Fertilization|Ovarian Stimulation
Interventions: DRUG: rFSH|DRUG: buserelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Vascular Reparative Therapy on Vasomotor Function and Myocardial Perfusion:a Randomized H215O PET/CT Study
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: Bioresorbable vascular scaffold|DEVICE: Xience Prime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Discriminant Capacity and Thresholds of Salivary Cortisol in Chemiluminescence in the Diagnosis of Hypercorticisms
Status: RECRUITING
Conditions: Cushing Disease
Interventions: DIAGNOSTIC_TEST: Blood test|DIAGNOSTIC_TEST: 24-hour Urine test|DIAGNOSTIC_TEST: Saliva swab|DIAGNOSTIC_TEST: Dexamethasone test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Erector Spinae Plane Block Versus General Anesthesia in Breast Cancer Surgeries
Status: COMPLETED
Conditions: Analgesia
Interventions: PROCEDURE: Bilevel erector spinae plane block|PROCEDURE: Single level erector spinae plane block|DRUG: Intravenous morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Power Spectral Analysis of EEG During Equi-MAC Inhalation Anesthesia
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Sevoflurane|DRUG: Desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Compare Efficacy of the MiniMed Paradigm REAL-Time System Vs. MDI in Subjects Naive to Insulin Pump Therapy
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: MiniMed Paradigm REAL-Time System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extended Treatment and Follow-up of Subjects Treated With Belumosudil in Study KD025-208 or Study KD025-213
Status: COMPLETED
Conditions: Chronic Graft-versus-host-disease
Interventions: DRUG: Belumosudil 200 mg QD|DRUG: Belumosudil 200 mg BID|DRUG: Belumosudil 400 mg QD
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interventional Study to Improve Adherence to Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia, Myelogenous, Chronic, BCR-ABL Positive|Medication Adherence
Interventions: BEHAVIORAL: Adherence-encouraging interventions - Group meeting|BEHAVIORAL: Adherence-encouraging interventions - Individual meetings|BEHAVIORAL: Adherence-encouraging interventions - Monthly phone calls
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Adding Exenatide to Insulin Therapy for Patients With Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Nonalcoholic Fatty Liver Disease|Type 2 Diabetes Mellitus
Interventions: DRUG: Exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety Study of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women
Status: COMPLETED
Conditions: Heavy Menstrual Bleeding|Uterine Fibroids
Interventions: OTHER: Elagolix Placebo|DRUG: E2/NETA|OTHER: E2/NETA Placebo|DRUG: Elagolix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility of the Use of the Dual Robotic Arm Accessory With the Levita Magnetic Surgical System in Laparoscopic Procedures
Status: COMPLETED
Conditions: Bariatric Surgery Candidate|Cholelithiases|Other Disease
Interventions: DEVICE: Dual Robotic Arm Accessory (DRAA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy and Safety of Etanercept Treatment in Patients With SAPHO Syndrome
Status: RECRUITING
Conditions: SAPHO Syndrome
Interventions: DRUG: Etanercept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D Supplementation on Allostatic Load and Chronic Stress Along Line of Control in Azad Jammu Kashmir
Status: NOT_YET_RECRUITING
Conditions: Mental Health Issue
Interventions: DIETARY_SUPPLEMENT: 25 hydroxy cholecalciferol (Vitamin D) /25(OH)D3.|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Feasibility and Examination of the Effects of Floatation-based REST on a Community Sample With PTSD
Status: RECRUITING
Conditions: Post-Traumatic Stress Disorders
Interventions: OTHER: Floatation-based reduced environmental stimulation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: How Does Platelet Dose Impact Clinical Outcomes After PRP Treatment?
Status: WITHDRAWN
Conditions: Osteoarthritis, Knee
Interventions: BIOLOGICAL: PRP injection dose (<5 billion platelets)|BIOLOGICAL: PRP injection dose (between 5 and <10 billion platelets)|BIOLOGICAL: PRP injection dose (between 10 and <20 billion platelets)|BIOLOGICAL: PRP injection dose (20 billion or greater platelets)|OTHER: Saline injection control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Non-invasive Brain Stimulation, Associated With Upper Limb Robot-assisted Therapy, on Motor Recuperation
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: tDCS (ELDITH) and RAT (REAplan)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of OC459 on the Response to Rhinovirus Challenge in Asthma
Status: COMPLETED
Conditions: Asthma|Rhinovirus|Picornaviridae Infections|Common Cold
Interventions: DRUG: OC459|DRUG: Placebo|OTHER: Rhinovirus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Fluids in Hospitalised Children
Status: COMPLETED
Conditions: Hypokalemia|Hyponatremia|Hypernatremia|Dehydration
Interventions: DRUG: Plasmalyte Glucos 50 mg/mL|DRUG: 0.45% saline in 5% dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel With or Without PI-88 in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: PI-88|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of EC0489 for the Treatment of Refractory or Metastatic Tumors
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: EC0489, Injection|DRUG: EC20|DRUG: EC0489, Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Evaluation of Intranasal and Intramuscular Naloxone in Healthy Volunteers
Status: COMPLETED
Conditions: Drug Overdose|Opioid-Related Disorders
Interventions: DRUG: Naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Fast Enteral Feeding in Preterm Infants Between 1000 and 2000 Grams of Birth Weight
Status: COMPLETED
Conditions: Feeding Behavior
Interventions: OTHER: Fast milk advancement|OTHER: Traditional milk advancement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Refractory Urge Incontinence and Botox Injections
Status: TERMINATED
Conditions: Urinary Incontinence|Detrusor Overactivity|Urinary Urgency|Urge Urinary Incontinence
Interventions: DRUG: Botulinum Toxin A, bladder detrusor muscle injection|DRUG: Vehicle saline as placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of 3M Oedema Reduction System in the Treatment of Lymphoedema Compared to Commercial Short-stretch Bandage
Status: COMPLETED
Conditions: Lymphedema
Interventions: DEVICE: 3M Coban 2 (Compression System)|DEVICE: 3M Coban 2 (Compression System)|DEVICE: 3M Coban 2 (Compression System)|DEVICE: Comprilan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Sinus Lift Technique With Simultaneous Implantation Using Platelet Rich Fibrin (PRF) Versus Nano-crystalline Hydroxyapatite
Status: UNKNOWN
Conditions: Atrophied Posterior Maxillary Ridge
Interventions: PROCEDURE: Evaluation of bone quantity in open sinus lift technique with simultaneous implantation ( Nano crystalline hydroxyapatite)|PROCEDURE: Evaluation of bone quantity in open sinus lift technique with simultaneous implantation (PRF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Paclitaxel, UFT, and Leucovorin in Patients With Metastatic Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Neoplasm
Interventions: DRUG: UFT (Tegafur/Uracil)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy of EMONO as an add-on Therapy to Conventional Antidepressants for the Treatment of Depressive Symptoms in Nursing-home Residents With Neurocognitive Disorders: a Randomized Controlled Trial-
Status: NOT_YET_RECRUITING
Conditions: Depression|Neurocognitive Disorders
Interventions: DRUG: EMONO|DRUG: Medical air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of Injectable Universal Flowable Composite in Proximal Cavities of Posterior Teeth.
Status: UNKNOWN
Conditions: Proximal Cavities of Posterior Teeth
Interventions: OTHER: PALFIQUE® Universal Flow; Tokuyama, Tokyo, Japan (super low flowability)|OTHER: ESTELITE® Alpha; Tokuyama, Tokyo, Japan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) in Schizophrenia : a Randomized Controlled Study
Status: COMPLETED
Conditions: Auditory Hallucinations in Patients With Schizophrenic Disorders
Interventions: DEVICE: Transcranial magnetic stimulation: rTMS|DEVICE: Placebo (sham coil) treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of NSAID on Travoprost-induced Conjunctival Hyperemia and IOP Reduction in Normal Eyes
Status: COMPLETED
Conditions: Hyperemia|Intraocular Pressure
Interventions: DRUG: dicrofenac and travoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose in African Americans
Status: ACTIVE_NOT_RECRUITING
Conditions: PreDiabetes|Impaired Glucose Tolerance|Obesity|Blood Pressure
Interventions: DRUG: Sacubitril-Valsartan Tab 97-103 MG|DRUG: Valsartan 160mg|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Nurse-led Supportive Care Programme on Caregiver Burden and Resilience of Family Caregivers
Status: COMPLETED
Conditions: Nurse-led Supportive Care
Interventions: BEHAVIORAL: Nurse-led Supportive Care Programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Pilot Study Comparing Effects of Nutrients Supplements and Dietary Approach in Frailty Management
Status: COMPLETED
Conditions: Frail Elderly
Interventions: DIETARY_SUPPLEMENT: "multi-nutrient" supplement|DIETARY_SUPPLEMENT: "multi-nutrient & soy protein" supplement|DIETARY_SUPPLEMENT: Nutrition education on balanced diet & food supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Optimization of Ventilation Strategies in Preterm and Term Infants in a Single-center Intervention Study
Status: COMPLETED
Conditions: Lung-protective Ventilation|Respiratory Function Monitor
Interventions: DEVICE: Ventilations while using a respiratory function monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of the Impact of Methotrexate (MTX) Discontinuation on the Efficacy of Subcutaneous (SC) Tocilizumab (TCZ) With MTX
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tocilizumab (TCZ)|DRUG: Methotrexate (MTX)|DRUG: Placebo (PBO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Post T-plant Infusion of Allogeneic Cytokine Induced Killer (CIK) Cells as Consolidative Therapy in Myelodysplastic Syndromes/Myeloproliferative Disorders
Status: COMPLETED
Conditions: Neural Tube Defects|Anemia|Leukemia, Myeloid|Bone Marrow Transplant Failure|Myelodysplastic Syndromes (MDS)|Myeloproliferative Disorders
Interventions: DRUG: CIK cells|DRUG: Cyclosporine|DRUG: Mycophenolate Mofetil|DRUG: Thymoglobulin|RADIATION: Total Lymphoid Irradiation (TLI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Flemish Umbilical Nitinol Mesh Trial, a Multicenter Trial
Status: COMPLETED
Conditions: Umbilical Hernia
Interventions: PROCEDURE: Intraperitoneal mesh placement|PROCEDURE: Preperitoneal mesh placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double Blind, Placebo Controlled Study of Etanercept in Children With Kawasaki Disease
Status: COMPLETED
Conditions: Mucocutaneous Lymph Node Syndrome|Kawasaki Disease
Interventions: DRUG: Etanercept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Aleglitazar in Combination With Metformin in Patients With Type 2 Diabetes Mellitus Who Are Inadequately Controlled With Sulfonylurea Alone or Sulfonylurea Plus Metformin Therapy
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: aleglitazar|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT