pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Using a Cold Atmospheric Plasma Device to Treat Skin Disorders
Status: RECRUITING
Conditions: Actinic Keratosis|Acne/Rosacea|Verruca Plana|Tinea|Molluscum Contagiosum|Bowen's Disease|Warts
Interventions: DEVICE: Non-thermal, atmospheric plasma to treat skin lesions and acne|DEVICE: Indirect non-thermal, atmospheric plasma to treat hair loss and acne
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cadonilimab (AK104) in the Treatment of Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Cadonilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial
Status: COMPLETED
Conditions: Gastrointestinal Hemorrhage (Clinically Important, Upper)
Interventions: DRUG: Placebo (0.9% saline)|DRUG: Pantoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Children's Attention Deficit Disorder With Hyperactivity (ADHD) Telemental Health Treatment Study
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: OTHER: CATMH intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Theranova Dialyzer and Chronic Kidney Disease - Mineral Bone Disorder (CKD-MBD)
Status: UNKNOWN
Conditions: End Stage Renal Failure on Dialysis|Vascular Calcification|Oxidative Stress
Interventions: DEVICE: Theranova dialyzer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Influenza Vaccine in HIV Infected Adults
Status: COMPLETED
Conditions: HIV|Influenza|Vaccination|HIV Infections
Interventions: BIOLOGICAL: MUTAGRIP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nivolumab With or Without Ipilimumab in Treating Patients With Persistent or Recurrent Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma
Interventions: BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EH301 for the Treatment of ALS
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: OTHER: EH301|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Run at Multiple Study Sites to Test Whether the SAMANTA Questionnaire That is Used to Diagnose Heavy Menstrual Bleeding (HMB), Can Also be Used to Assess Changes of Severity of HMB in Women With HMB Who Are Treated During 12 Months With a Chronic Hormonal Treatment
Status: COMPLETED
Conditions: Menorrhagia
Interventions: DRUG: Chronic hormonal treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Simultaneous Integrated Boost in Malignant Glioma Patients Treated With Chemoradiation
Status: UNKNOWN
Conditions: Glioblastoma Multiforme|Chemoradiation
Interventions: RADIATION: Simultaneous integrated boost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of KB301, a Replication-Incompetent, Non-Integrating Vector Expressing Human Type III Collagen (COL3) for the Treatment of Superficial Skin Depressions
Status: RECRUITING
Conditions: Skin Roughness|Wrinkle|Fine Lines|Skin Thickness
Interventions: BIOLOGICAL: KB301|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Application of Virtual Reality (VR) and Human Computer Interaction System in the ICU Patients
Status: UNKNOWN
Conditions: Rehabilitation Exercise of ICU Patients
Interventions: BEHAVIORAL: Virtual Reality (VR) and human computer interaction system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hypersensitivity and Color Changes of Bleached Teeth Using Different Remineralizing Agents
Status: COMPLETED
Conditions: Tooth Hypersensitivity
Interventions: OTHER: Remineralizing agent I application|OTHER: Remineralizing agent II application|OTHER: Remineralizing agent III application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Circulating Tumor DNA in Predicting Outcomes in Patients With Stage IV Head and Neck Cancer or Stage III-IV Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma|Salivary Gland Squamous Cell Carcinoma|Stage IIIA Non-small Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer|Stage IV Squamous Cell Carcinoma of the Hypopharynx|Stage IV Squamous Cell Carcinoma of the Nasopharynx|Stage IVA Salivary Gland Cancer|Stage IVA Squamous Cell Carcinoma of the Larynx|Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVA Squamous Cell Carcinoma of the Oropharynx|Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVA Verrucous Carcinoma of the Larynx|Stage IVA Verrucous Carcinoma of the Oral Cavity|Stage IVB Salivary Gland Cancer|Stage IVB Squamous Cell Carcinoma of the Larynx|Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVB Squamous Cell Carcinoma of the Oropharynx|Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVB Verrucous Carcinoma of the Larynx|Stage IVB Verrucous Carcinoma of the Oral Cavity|Stage IVC Salivary Gland Cancer|Stage IVC Squamous Cell Carcinoma of the Larynx|Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVC Squamous Cell Carcinoma of the Oropharynx|Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Stage IVC Verrucous Carcinoma of the Larynx|Stage IVC Verrucous Carcinoma of the Oral Cavity|Tongue Cancer|Untreated Metastatic Squamous Neck Cancer With Occult Primary
Interventions: OTHER: Cytology specimen|OTHER: Laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase IV Multi-arm Study of CDK4/6 Pharmacokinetics in Healthy Volunteers With Known CYP3A4*22 Genotype
Status: WITHDRAWN
Conditions: CYP3A4*22
Interventions: DRUG: Palbociclib 125Mg Tab|DRUG: Ribociclib 200Mg Oral Tablet|DRUG: Abemaciclib 150 MG Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effective Translation of Endovascular Thrombectomy Trials Into Real-world Practice in the Asia-Pacific
Status: RECRUITING
Conditions: Ischemic Stroke|Stroke|Stroke, Acute|Stroke, Ischemic|Brain Diseases|Major Adverse Cardiovascular Event
Interventions: DIAGNOSTIC_TEST: Thrombus analyses|DIAGNOSTIC_TEST: Imaging assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pathogenesis of Youth Onset Type 2 Diabetes and Prediabetes
Status: COMPLETED
Conditions: IGT - Impaired Glucose Tolerance|T2D
Interventions: DIAGNOSTIC_TEST: Oral Glucose Tolerance Test|DIAGNOSTIC_TEST: Hyperglycemic Clamp|DIAGNOSTIC_TEST: Isoglycemic Intravenous Glucose Test|DIAGNOSTIC_TEST: Hyperinsulinemic Euglycemic Clamp and 2H20
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Technology Interventions to Improve Outcomes After Knee Replacement
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee Arthroplasty
Interventions: BEHAVIORAL: NEAT!2|BEHAVIORAL: MyKneeGuide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Statin and Bone Health
Status: ENROLLING_BY_INVITATION
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Simvastatin 10mg|DRUG: Ezetimibe 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Dexamethasone Combined With Ondansetron on Postoperative Nausea and Vomiting in Patients With Patient-controlled Analgesia After Video-assisted Thoracoscopic Surgery
Status: COMPLETED
Conditions: Nausea|Vomiting
Interventions: DRUG: Dexamethasone|DRUG: Ondansetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of ProHema Modulated Umbilical Cord Blood Units in Subjects With Hematologic Malignancies.
Status: COMPLETED
Conditions: Hematologic Malignancies|Allogeneic Stem Cell Transplantation
Interventions: DRUG: Fludarabine|DRUG: Melphalan|DRUG: Antithymocyte Globulin|DRUG: Sirolimus|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug Interaction Study Evaluating Plasma GSK2248761 and GSK1349572 Pharmacokinetics in Healthy Adult Subjects.
Status: WITHDRAWN
Conditions: Infection, Human Immunodeficiency Virus I
Interventions: DRUG: GSK1349572|DRUG: GSK2248761
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Brentuximab Vedotin and Combination Chemotherapy in Treating Patients With CD30-Positive Peripheral T-cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Adult T-Cell Leukemia/Lymphoma|Anaplastic Large Cell Lymphoma, ALK-Negative|Anaplastic Large Cell Lymphoma, ALK-Positive|Angioimmunoblastic T-Cell Lymphoma|Ann Arbor Stage II Noncutaneous Anaplastic Large Cell Lymphoma|Ann Arbor Stage III Noncutaneous Anaplastic Large Cell Lymphoma|Ann Arbor Stage IV Noncutaneous Anaplastic Large Cell Lymphoma|Enteropathy-Associated T-Cell Lymphoma|Hepatosplenic T-Cell Lymphoma|Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma|Peripheral T-Cell Lymphoma, Not Otherwise Specified
Interventions: DRUG: Brentuximab Vedotin|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Doxorubicin Hydrochloride|DRUG: Etoposide|DRUG: Etoposide Phosphate|OTHER: Laboratory Biomarker Analysis|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FAPI-CUP- Evaluating FAPI as a Novel Radiopharmaceutical for Cancer of Unknown Primary
Status: RECRUITING
Conditions: Cancer of Unknown Primary Site
Interventions: DRUG: 68Ga-FAPi-46|PROCEDURE: PET/CT imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of KNT® (KINETUBE) in Recurrent Chronic Otitis Media in Children
Status: UNKNOWN
Conditions: Chronic Otitis Infections in pédiatric Patients
Interventions: DEVICE: KINETUBE medical Device|DEVICE: insertion of tympanic ventilation tubes (tympanostomy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Community-Based Programs for Improving Physical Function in People With Early Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: OTHER: Physical training program|BEHAVIORAL: Self-management training program|OTHER: Physical training and self-management training programs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A One-arm Exploratory Clinical Research Program Study of Apatinib in Advanced Metastatic Renal Cell Carcinoma Patients.
Status: UNKNOWN
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Novel Respirator With Chitosan Nanoparticles
Status: COMPLETED
Conditions: Covid19|SARS-CoV Infection|Worker-Patient Transmission, Healthcare
Interventions: DEVICE: VESTA respirator|DEVICE: Conventional N95 respirator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Use of Ozone Gel Versus Hyaluronic Acid Gel on Palatal Wound Healing .
Status: NOT_YET_RECRUITING
Conditions: Palate; Wound
Interventions: DRUG: GeliO3|DRUG: Gingi gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prolonged Infusion Cefepime and Nosocomial Infections
Status: UNKNOWN
Conditions: Urinary Tract Infection|Respiratory Tract Infection
Interventions: DRUG: Prolonged Cefepime Infusion|DRUG: Usual Cefepime Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Helicobacter Pylori Infection a Cause or Treatment Failure of Iron Deficiency Anemia in Children in Bangladesh?
Status: COMPLETED
Conditions: Helicobacter Pylori Infection|Iron Deficiency Anemia|Not Severely Malnourished|No Systemic Infection|Children
Interventions: DRUG: Iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: FM101 Safety, Tolerability, Efficacy Study in the Patients With Ocular Hypertension
Status: UNKNOWN
Conditions: Ocular Hypertension
Interventions: DRUG: FM101 tablet|DRUG: FM101 oral solution|DRUG: Placebo|DRUG: FM101 150 mg|DRUG: FM101 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Individualized Strategies of Red Blood Cell Transfusion for Perioperative Pediatric Patients
Status: WITHDRAWN
Conditions: Individualized Transfusion Strategy|Red Blood Cell|Perioperative Pediatric Patient|Clinical Outcome
Interventions: DIAGNOSTIC_TEST: clinical condition score
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Probiotics on Symptoms of Infantile Colic
Status: WITHDRAWN
Conditions: Colic
Interventions: DIETARY_SUPPLEMENT: Probiotic Formulation|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lenvatinib Plus PD-1 Antibody for Unresectable ICC
Status: SUSPENDED
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: DRUG: Lenvatinib|DRUG: PD-1 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 19(T2)28z1xx Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Diffuse Large B Cell Lymphoma|Primary Mediastinal Large B Cell Lymphoma|Transformed Follicular Lymphoma to Diffuse Large B Cell Lymphoma|Chronic Lymphocytic Leukemia|Indolent Non-Hodgkin Lymphoma|Marginal Zone Lymphoma|Waldenstrom Macroglobulinemia|Burkitt's Lymphoma|Primary CNS Lymphoma
Interventions: DRUG: 19(T2)28z1xx CAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary sarcomatoid_MEDI4736+Treme
Status: COMPLETED
Conditions: Durvalumab + Tremelimumab Combination Treatment, Pulmonary Sarcomatoid Carcinoma, NSCLC
Interventions: DRUG: durvalumab + tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Immunogenicity of Heterologous Prime-Boost Ebola Vaccine Regimens in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: MVA-BN-Filo|BIOLOGICAL: Ad26.ZEBOV|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Intraoperative Laser Speckle Contrast Imaging to Assess Blood Flow During Neurosurgery
Status: COMPLETED
Conditions: Aneurysm|AVM|Dural Arteriovenous Fistula|Glioma|Meningioma|Metastasis
Interventions: DEVICE: Laser speckle contrast imaging (LSCI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Botulinum Toxin to Hallux Valgus in Addition to Total Contact Insole
Status: COMPLETED
Conditions: Hallux Valgus
Interventions: DRUG: BOTOX|DRUG: Normal Saline (0.9% NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: S-ESP and Ring Block in Circümcision Surgery (S-ESP: Sacral Erectör Spinae Plane Block).
Status: COMPLETED
Conditions: Pain|Pain, Postoperative
Interventions: OTHER: Sacral erectör spinae plane block|OTHER: Ring Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Value of Preoperative Oral Carbohydrate Loading in Colorectal Surgery
Status: COMPLETED
Conditions: Colorectal Disorders|Colorectal Surgery
Interventions: DIETARY_SUPPLEMENT: commercially available high-carbohydrate beverage|DIETARY_SUPPLEMENT: flavored water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: rAAVrh74.MHCK7.DYSF.DV for Treatment of Dysferlinopathies
Status: COMPLETED
Conditions: Dysferlinopathy
Interventions: DRUG: rAAVrh74.MHCK7.DYSF.DV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: S0355 Ixabepilone in Treating Patients With Advanced Solid Tumors or Lymphomas and Liver Dysfunction
Status: COMPLETED
Conditions: Lymphoma|Small Intestine Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: BMS-247550
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Differential Efficacy of Guided Imagery Psychotherapy: Non-Inferiority Trial and Exploration of Differential Indication
Status: RECRUITING
Conditions: Emotional Disorders
Interventions: BEHAVIORAL: weekly, biweekly, or twice a week sessions of face-to-face outpatient psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Personality in Parkinson's Disease Patients With Other Chronic Pain
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: TCI|OTHER: BPI|OTHER: CPAQ-8|OTHER: SF-MPQ|OTHER: King's Parkinson's Disease Pain Scale (KPPS)|OTHER: Hospital Anxiety and Depression scale (HAD) questionary|OTHER: PCS|OTHER: ORT|OTHER: Social Support Questionnaire (SSQ6)|OTHER: IPQ-R|OTHER: WCC-R
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comparison of Nasal Versus Oral Fiberoptic Intubation in Children
Status: COMPLETED
Conditions: Tracheal Intubation
Interventions: OTHER: Fiberoptic Intubation through the nasal route|OTHER: Fiberoptic intubation through the oral route
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Linked Color Imaging Versus White Light Endoscopy for the Evaluation of Scars of Non-pedunculated Polyps. LCI Scar Study.
Status: COMPLETED
Conditions: Polyp of Colon
Interventions: DEVICE: Linked Color Imaging|OTHER: White light endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Epirubicin in Treating Women Who Are Undergoing Surgery for Stage I, Stage II, or Stage III Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: pegfilgrastim|DRUG: epirubicin hydrochloride|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study Comparing Active Drug in the Blood in Healthy Participants Following Dosing of the Current and a New Formulation (D) Semaglutide Tablets
Status: COMPLETED
Conditions: Healthy Volunteers|Type 2 Diabetes
Interventions: DRUG: Oral semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Application of Zishen Yutai Pill in Aged Women Undergoing IVF-ET
Status: COMPLETED
Conditions: Infertility, Female
Interventions: DRUG: Zishen Yutai Pill|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of P1101 in Polycythemia Vera Patients for Whom the Standard of Treatment is Difficult to Apply
Status: COMPLETED
Conditions: Polycythemia Vera (PV)
Interventions: DRUG: P1101|DRUG: Low-dose aspirin|PROCEDURE: Phlebotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-time Optimized Biofeedback Utilizing Sport Techniques
Status: COMPLETED
Conditions: Knee Injuries
Interventions: OTHER: Neuromuscular Training|OTHER: Hip Focused ROBUST Training|OTHER: Knee Focused ROBUST Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Repetitive Transcranial Stimulation (r-TMS) Treatment for Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DEVICE: repetitive transcranial stimulation (r-TMS)|DEVICE: Repetitive transcranial stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NALIRIFOX in Combination With Camrelizumab for BRPC: a Prospective, Exploratory Study
Status: RECRUITING
Conditions: Borderline Resectable Pancreatic Cancer
Interventions: DRUG: Liposomal Irinotecan, Oxaliplatin, 5-Fluorouracil/Calcium folinate in combination with Camrelizumab|DRUG: Liposomal Irinotecan, Oxaliplatin, 5-Fluorouracil/Calcium folinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of JS002 PFS and AI in Patients With Primary Hypercholesterolemia and Mixed Hyperlipidemia
Status: COMPLETED
Conditions: Hyperlipemia
Interventions: DRUG: JS002|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cross-over Study to Evaluate the Rate and the Extent of Iron Absorption of an ODF Iron Supplement vs an Iron Supplement in Capsules
Status: COMPLETED
Conditions: Iron-deficiency
Interventions: DIETARY_SUPPLEMENT: IBSA Iron ODF|DIETARY_SUPPLEMENT: SiderAL® FORTE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Implementation of the Intravitreal Injection Administered by Nurses
Status: NOT_YET_RECRUITING
Conditions: Macular Edema|Macular Degeneration|Diabetic Macular Edema
Interventions: PROCEDURE: It is a implementation a program incorporating nurses trained in administering intravitreal injections within the functional unit of Ophthalmology following the usual technique
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of CTAP101 to Treat Secondary Hyperparathyroidism in Stage 3 or 4 CKD and Vitamin D Insufficiency
Status: COMPLETED
Conditions: Chronic Kidney Disease|Hyperparathyroidism, Secondary|Vitamin D Deficiency
Interventions: DRUG: CTAP101 30 μg capsules|OTHER: Sugar pill to CTAP101 30 μg capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ticagrelor Compared to Clopidogrel in Acute Coronary Syndromes
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Ticagrelor 90mg|DRUG: Clopidogrel 75mg|DRUG: acetylsalicylic acid (ASA) 81mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Oxytocin Administration on Interpersonal Cooperation in Borderline Personality Disorder Patients and Healthy Adults
Status: SUSPENDED
Conditions: Borderline Personality Disorder
Interventions: DRUG: 40 IU Intranasal Oxytocin|DRUG: Placebo|DRUG: 24 IU intranasal Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Treatment of Osteopenia With Melatonin
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Arterial Oxygen Saturation on Ventilatory Stability in Extremely Premature Infants
Status: COMPLETED
Conditions: Apnea of Prematurity|Desaturation of Blood|Central Apnea|Periodic Breathing|Obstructive Apnea of Newborn
Interventions: OTHER: Targeting SpO2 at 93-95%|OTHER: Targeting SpO2 at 90-92%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Pharmacology of p38 MAP Kinase Inhibitor, VX-745, in Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: VX-745
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enteric-coated Mycophenolate Sodium (EC-MPS) and Mycophenolate Mofetil (MMF) in Renal Transplant Patients With Gastrointestinal (GI) Intolerance
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: Enteric-coated mycophenolate sodium (EC-MPS)|DRUG: Mycophenolate mofetil|DRUG: Placebo to mycophenolate sodium|DRUG: Placebo to mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erlotinib in Treating Patients With Barrett Esophagus
Status: UNKNOWN
Conditions: Esophageal Cancer|Precancerous Condition
Interventions: DRUG: erlotinib hydrochloride|OTHER: laboratory biomarker analysis|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of E7386 in Participants With Advanced Solid Tumor Including Colorectal Cancer (CRC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Neoplasms|Colorectal Neoplasms|Gastrointestinal Tumors
Interventions: DRUG: E7386
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coronally Advanced Flap With or Without Porcine Collagen Matrix for Root Coverage
Status: COMPLETED
Conditions: Gingival Recession
Interventions: PROCEDURE: Coronally Advanced Flap|DEVICE: Mucograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CAR-T Cell Therapy in RelApsed/Refractory Myeloma With ExtrameduLlary Disease - an in Vivo Imaging and Molecular Monitoring Study
Status: RECRUITING
Conditions: Extramedullary Myeloma
Interventions: BIOLOGICAL: Combination Product: JNJ-68284528 (Cilta-cel) & 64Cu SPION dual PET-MR imaging agent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Mifepristone in Males With Type 2 Diabetes Mellitus
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus|Insulin Resistance
Interventions: DRUG: Mifepristone 600 mg daily|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses in Healthy
Status: COMPLETED
Conditions: Healthy Subjects|Osteoarthritis
Interventions: DRUG: AGG-523
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Presence Of Sarcopenia In Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Sarcopenia|Osteoarthritis
Interventions: DIAGNOSTIC_TEST: Musculoskeletal ultrasound|DIAGNOSTIC_TEST: Dual-X-ray absorptiometry|DIAGNOSTIC_TEST: Isokinetic dynamometer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Memantine for Parkinson's Disease Dementia (PDD) and Dementia With Lewy Bodies (DLB)
Status: COMPLETED
Conditions: Dementia Associated With Parkinson's Disease|Dementia With Lewy Bodies
Interventions: DRUG: Memantine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Farming for Life - Health Impact of Organic Vegetable Prescriptions for Adults Living With or at Risk of Type 2 Diabetes
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2|Food Supply|Poverty|Minority Health|Obesity
Interventions: DIETARY_SUPPLEMENT: Fresh organic vegetables
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Label Pharmacokinetic, Safety And Efficacy Study Of Maraviroc In Combination With Background Therapy For The Treatment Of HIV-1 Infected, CCR5 -Tropic Children
Status: UNKNOWN
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: Maraviroc
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CYP2D6 Screening for Adverse Drug Reactions to Codeine in Breast Milk
Status: COMPLETED
Conditions: Cytochrome P450 2D6 Ultra-rapid Metabolism
Interventions: GENETIC: Cytochrome P450 2D6 (CYP2D6) genetic screening.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy, Safety, and Pharmacokinetics of Intravenous Ibuprofen in Adult Febrile Patients
Status: COMPLETED
Conditions: Fever
Interventions: DRUG: Ibuprofen|DRUG: Ibuprofen|DRUG: Ibuprofen|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Itraconazole and Pemetrexed in Patients With Previously Treated Non-Squamous NSCLC
Status: TERMINATED
Conditions: Recurrent Non Small Cell Lung Cancer
Interventions: DRUG: Itraconazole|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Moderately Hypofractionated Adaptive Radiotherapy for Cervical Cancer
Status: RECRUITING
Conditions: Cervical Neoplasm|Adaptive Radiotherapy|Radiotherapy; Adverse Effect
Interventions: RADIATION: Moderately hypofractionated adaptive radiotherapy (ART)+ High-dose rate (HDR) Brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment With Combination Chemotherapy for Relapsed or Refractory Acute Lymphoblastic Leukemia
Status: TERMINATED
Conditions: Acute Lymphoblastic Leukemia, in Relapse|Acute Lymphoblastic Leukemia With Failed Remission
Interventions: DRUG: Palbociclib Oral Capsule|DRUG: Intrathecal Triple Therapy|DRUG: Dexamethasone|DRUG: Bortezomib|DRUG: Dasatinib|DRUG: Doxorubicin|DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of an Alginate Containing Enteral Feed and an Alginate Free Enteral Feed.
Status: COMPLETED
Conditions: Enteral Nutrition
Interventions: DIETARY_SUPPLEMENT: MerMed One|DIETARY_SUPPLEMENT: Nutricomp Soy Fibre
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Exosome of Mesenchymal Stem Cells for Multiple Organ Dysfuntion Syndrome After Surgical Repaire of Acute Type A Aortic Dissection
Status: NOT_YET_RECRUITING
Conditions: Multiple Organ Failure
Interventions: BIOLOGICAL: Exosome of MSC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Color Stability of Direct Composite Resin Veneers in Vital Anterior Teeth
Status: COMPLETED
Conditions: Tooth Discoloration
Interventions: OTHER: OMNICHROMA|OTHER: Ceram. x spectra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Aromatase Inhibitor(AI) With Ovarian Suppression Versus Chemotherapy in Premenopausal Breast Cancer Patients
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Neoadjuvant endocrine therapy|DRUG: Neoadjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Cetuximab and the Hedgehog Inhibitor IPI-926 in Recurrent Head and Neck Cancer
Status: COMPLETED
Conditions: Recurrent Head and Neck Cancer
Interventions: DRUG: IPI-926 and Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sustainability of Impacts of Cash Transfers, Food Transfers, and Behavior Change Communication in Bangladesh
Status: COMPLETED
Conditions: Food Security|Poverty|Child Nutrition|Child Development|Intimate Partner Violence|Gender Dynamics
Interventions: OTHER: Cash transfer|OTHER: Food transfer|OTHER: Food and cash transfer|BEHAVIORAL: Nutrition behavior Communication Change (BCC)|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pilot, Open-label Study of 18F-Fluciclatide PET/CT Imaging in the Evaluation of Anti-angiogenic Therapy in Solid Tumors
Status: WITHDRAWN
Conditions: Colon Cancer|Lung Cancer|Cervical Cancer|Renal Cell Carcinoma|Uterine Cancer
Interventions: DRUG: (18)Fluciclatide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial of High Dose Melphalan/Stem Cell Transplant With or Without Bortezomib
Status: TERMINATED
Conditions: AL Amyloidosis
Interventions: DRUG: Bortezomib|DRUG: Melphalan|DRUG: Neupogen|PROCEDURE: Stem Cell Collection|PROCEDURE: Stem cell infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on the Effects of Interventional Therapy in Patients With Lower Extremity Arterial Occlusive Disease and Its Risk Factors(EILRF)
Status: UNKNOWN
Conditions: PAD
Interventions: PROCEDURE: Percutaneous transluminal angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study, Evaluating the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Advanced Solid Malignancies
Interventions: DRUG: PRJ1-3024
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BIS-guided Fluid Management in HD Patients
Status: COMPLETED
Conditions: Kidney Failure|Haemodialysis Fluid Adverse Reaction
Interventions: DEVICE: Spectroscopy Bioimpedance Analysis|OTHER: Clinical Examination alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Karma Intervention Study
Status: COMPLETED
Conditions: Risk Reduction|Mammographic Density Reduction
Interventions: DRUG: Tamoxifen Oral Tablet|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase I Dose Finding and Safety Study of Oral LDE225 in Children and a Phase II Portion to Assess Preliminary Efficacy in Recurrent or Refractory MB
Status: COMPLETED
Conditions: Medulloblastoma|Rhabdomyosarcoma|Neuroblastoma|Hepatoblastoma|Glioma|Astrocytoma
Interventions: DRUG: LDE225
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Pemetrexed and Gefitinib Versus Gefitinib in Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Carcinoma, Non Small Cell Lung
Interventions: DRUG: Gefitinib|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetic Mitohormesis: Effect of Magnetic Signals on Metabolic Adaptions in Type 2 Diabetes (MENSA-T2D)
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DEVICE: Magnetic mitohormesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Natalizumab in the Treatment of Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Natalizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety Extension Trial of Asenapine in Schizophrenia Participants Who Completed Protocol P05688 (P05689)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Asenapine|DRUG: Placebo Asenapine|DRUG: Olanzapine|DRUG: Placebo Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of the Dextenza 0.4mg Intracanalicular Insert Delivery System Used in Cataract Surgery
Status: TERMINATED
Conditions: Cataract
Interventions: DRUG: Dextenza 0.4mg intracanalicular Insert|DRUG: Durezol 0.05% Ophthalmic Emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EUropean Pharmacogenetics of AntiCoagulant Therapy - Warfarin
Status: COMPLETED
Conditions: Venous Thromboembolism|Atrial Fibrillation
Interventions: OTHER: Genotype-guided dosing algorithm|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Effectiveness of Video-game Based Swallowing Function Training in Patients With Dysphagia
Status: RECRUITING
Conditions: Deglutition Disorders|Rehabilitation|Video Game
Interventions: DEVICE: Video-game|BEHAVIORAL: Conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interaction Study of Glucokinase Activator HMS5552 and Metformin in T2DM
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Metformin|DRUG: HMS5552
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab With Trametinib and Dabrafenib, or Encorafenib and Binimetinib in Treating Patients With BRAF Mutated Metastatic or Unresectable Stage III-IV Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Malignant Neoplasm in the Brain|Metastatic Melanoma|Stage III Cutaneous Melanoma AJCC v7|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7|Unresectable Melanoma
Interventions: DRUG: Binimetinib|DRUG: Dabrafenib|DRUG: Encorafenib|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Nivolumab|OTHER: Pharmacological Study|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Povorcitinib on Digoxin, Rosuvastatin, and Metformin Pharmacokinetics When Administered Orally to Healthy Adult Participants
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: Digoxin|DRUG: Rosuvastatin|DRUG: Metformin|DRUG: Povorcitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Determine the Dose-dependent Efficacy and Safety of EC-18 in Patients With Moderate or Severe Atopic Dermatitis
Status: NOT_YET_RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: EC-18|DRUG: Placebo EC-18
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety And Efficacy Of UK-432,097 In Chronic Obstructive Pulmonary Disease.
Status: TERMINATED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: UK-432,097|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-epitope Folate Receptor Alpha Peptide Vaccine, GM-CSF, and Cyclophosphamide in Treating Patients With Triple Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Bilateral Breast Carcinoma|Breast Inflammatory Carcinoma|Stage IB Breast Cancer AJCC v7|Stage II Breast Cancer AJCC v6 and v7|Stage IIA Breast Cancer AJCC v6 and v7|Stage IIB Breast Cancer AJCC v6 and v7|Stage III Breast Cancer AJCC v7|Stage IIIA Breast Cancer AJCC v7|Stage IIIB Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7|Triple-Negative Breast Carcinoma|Unilateral Breast Carcinoma
Interventions: DRUG: Cyclophosphamide|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Multi-epitope Folate Receptor Alpha Peptide Vaccine|OTHER: Placebo Administration|BIOLOGICAL: Sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: FRENCH THERAPEUTIC EDUCATION PROGRAM AIMING TO IMPROVE LARYNGECTOMIZED PATIENTS' AND THEIR FAMILY CAREGIVER'S QUALITY OF LIFE
Status: UNKNOWN
Conditions: Patients With Total Laryngectomy and Their Close Relatives
Interventions: OTHER: PETAL program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Establishment of the National Registry for Inherited Retinal Dystrophy in Iran
Status: UNKNOWN
Conditions: Inherited Retinal Dystrophy Primarily Involving Sensory Retina|Inherited Retinal Dystrophy Primarily Involving Retinal Pigment Epithelium
Interventions: DIAGNOSTIC_TEST: Visual Acuity Testing and Retinal Imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating in Vivo PARP-1 Expression With 18F-FluorThanatrace Positron Emission Tomography (PET/CT) in Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DEVICE: [18F]FluorThanatrace|DRUG: Poly(ADP Ribose) Polymerase 1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine How BI 907828 (Brigimadlin) is Taken up in the Tumor (Phase 0) and to Determine the Highest Dose of BI 907828 (Brigimadlin) That Could be Tolerated (Phase 1a) in Combination With Radiation Therapy in People With a Brain Tumor Called Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: BI 907828 (Brigimadlin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study With Empagliflozin (BI 10773) vs. Placebo as add-on to Metformin or Metformin Plus Sulfonylurea Over 24 Weeks in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo identical to BI 10773 high dose|DRUG: Placebo identical to BI 10773 low dose|DRUG: BI 10773|DRUG: BI 10773|DRUG: Placebo identical to BI 10773 low dose|DRUG: BI 10773|DRUG: Placebo identical to BI 10773 high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT