pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Histopathology Following CCH Injection
Status: COMPLETED
Conditions: Characteristics of Subcutaneous Tissue
Interventions: DRUG: Collagenase Clostridium Histolyticum Single Injection Technique|DRUG: Collagenase Clostridium Histolyticum Multiple Injection Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Prefabricated Foot Orthoses With and Without Metatarsal Pads on Central Metatarsalgia
Status: COMPLETED
Conditions: Metatarsalgia
Interventions: DEVICE: Prefabricated foot orthoses (PFO) with metatarsal pads|DEVICE: Prefabricated foot orthoses (PFO) without metatarsal pads
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilate Mat Exercise Versus Muscle Energy Technique on Chronic Non Specific Low Back Pain
Status: UNKNOWN
Conditions: Chronic Non Specific Low Back Pain
Interventions: OTHER: pilate mat exercise will be performed|OTHER: MET|OTHER: control group receive standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study Evaluating the Safety and Efficacy of GSK315234A in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: GSK3152314A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sulindac and Breast Density in Women at Risk of Developing Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Sulindac Pill|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics and Breastmilk Decrease Risk of Atopic Dermatitis in Premature Infants
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: COMBINATION_PRODUCT: Lacticaseibacillus rhamnosus|COMBINATION_PRODUCT: Lactobacillus acidophilus + Bifidobacterium bifidum
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prebiotics and Microbiota Composition and Functionality in Rural Burkinabe Infants
Status: COMPLETED
Conditions: Growth Retardation|Infant Morbidity
Interventions: DIETARY_SUPPLEMENT: Fortified lipid based nutrient supplement|DIETARY_SUPPLEMENT: lipid based nutrient supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of NT 201 (IncobotulinumtoxinA [Xeomin]) in the Treatment of Glabellar Frown Lines
Status: COMPLETED
Conditions: Glabellar Lines
Interventions: DRUG: IncobotulinumtoxinA (Xeomin) (20 units)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Insulins Glargine and gluLisine strAtegy Versus Premixed Insulin strAteGy: a cOmparative Study
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: INSULIN GLARGINE|DRUG: INSULIN GLULISINE|DRUG: PREMIXED INSULIN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Local Administration of Morphine for Analgesia After Iliac Bone Graft Harvest
Status: WITHDRAWN
Conditions: Autogenous Bone Grafts
Interventions: DRUG: morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of Iontophoresis and Dexamethasone Phosphate to Treat Anterior Uveitis
Status: COMPLETED
Conditions: Uveitis, Anterior
Interventions: DRUG: EGP-437 1.6 mA-min at 0.4 with EyeGate® II System|DRUG: EGP-437 4.8 mA-min at 1.2 mA with EyeGate® II System|DRUG: EGP-437 10.0 mA-min at 2.5 mA with EyeGate® II System|DRUG: EGP-437 14.0 mA-min at 3.5 mA with EyeGate® II System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Young Adult Naturalistic Alcohol Study (YANAS) Using Smartphone Technology in a Simulated Laboratory Environment
Status: TERMINATED
Conditions: Alcohol Use|Alcohol Drinking|Drinking Behavior
Interventions: DEVICE: Smartphone breathalyzer device/app use|DEVICE: BAC estimator app use|DEVICE: Text messaging procedure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use of Fractional CO2 Laser Versus Erbium:YAG Laser for the Treatment of GSM in Patients Using Aromatase Inhibitors
Status: RECRUITING
Conditions: Genitourinary Syndrome of Menopause
Interventions: DEVICE: intravaginal laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-Blind, Placebo-Controlled, MAD Study to Assess the Safety, Tolerability, and Pharmacokinetics of SXC 2023
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: SXC-2023|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ¿Can mySugr App Improve Knowledge and Self-management of People With Type 1 Diabetes Mellitus?
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DEVICE: mySugr app|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Physical Activity in Children During Hematopoietic Stem Cells Transplantation (HSCT)
Status: COMPLETED
Conditions: Hematopoietic Stem Cell Transplantation|Child|Adolescent
Interventions: OTHER: exercise and rehabilitation counselling|BEHAVIORAL: rehabilitation counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Oral Prednisolone in Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: COPD Exacerbation
Interventions: DRUG: Prednisolone|DRUG: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Bivalirudin During Short-term Intervention of Non-infarction Related Artery After PPCI of STEMI
Status: UNKNOWN
Conditions: STEMI With Multivessel Coronary Disease
Interventions: DRUG: Bivalirudin|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sofosbuvir/Ledipasvir Fixed-Dose Combination ± Ribavirin in Cirrhotic Subjects With Chronic Genotype 1 HCV Infection
Status: COMPLETED
Conditions: HCV Infection
Interventions: DRUG: LDV/SOF|DRUG: RBV|DRUG: Placebo to match LDV/SOF|DRUG: Placebo to match RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study to Evaluate the Safety and Immunogenicity of PnuBioVax
Status: COMPLETED
Conditions: Pneumococcal Infection
Interventions: BIOLOGICAL: PnuBioVax|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Comparative, Pharmacokinetic Study of CB-839 Capsule and Tablet Formulations in Healthy Adults
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: CB-839 Capsules|DRUG: CB-839 Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subjective Comfort With Multipurpose Care Solutions in Soft Contact Lens Wearers
Status: COMPLETED
Conditions: Myopia|Astigmatism|Refractive Error
Interventions: DEVICE: OPTI-FREE RepleniSH multipurpose solution|DEVICE: ReNu Biotrue multipurpose solution|DEVICE: Silicone hydrogel contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Paclitaxel Eluting Stent or Exercise for Thigh Atherosclerosis
Status: UNKNOWN
Conditions: Peripheral Arterial Disease
Interventions: PROCEDURE: Angioplasty with Zilver PTX|OTHER: Best medical treatment|DEVICE: Zilver PTX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clarithromycin in Multiple Myeloma Induction Therapy
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Clarithromycin|DRUG: Placebo|DRUG: VCD induction therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment Of GW815SF HFA MDI In Pediatric Patients With Bronchial Asthma
Status: COMPLETED
Conditions: Bronchial Asthma
Interventions: DRUG: GW815SF HFA MDI|DRUG: salmeterol and fluticasone propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing the Efficacy of Subcutaneous Injections of Brodalumab to Oral Administrations of Fumaric Acid Esters in Adults With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: BIOLOGICAL: Brodalumab|DRUG: Fumaric acid esters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MK0431A vs. Pioglitazone in Patients With Type 2 Diabetes Mellitus (0431A-066)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: sitagliptin phosphate (+) metformin hydrochloride|DRUG: Comparator: pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect Of NS-0200 and NS-0300 Versus Placebo on Weight In Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Leu Sil 1.0mg|DRUG: Leu Sil 4.0mg|DRUG: Leu Met Sil 1.0mg|DRUG: Leu Met Sil 4.0mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Ipilimumab After Stem Cell Transplantation in People With Relapsed/Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Relapsed/Refractory Multiple Myeloma
Interventions: DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Adjuvant Cretostimogene Grenadenorepvec for Treatment of Intermediate Risk NMIBC Following TURBT
Status: RECRUITING
Conditions: Non Muscle Invasive Bladder Cancer|Urologic Cancer|Bladder Cancer|Urothelial Carcinoma
Interventions: DRUG: Cretostimogene Grenadenorepvec|OTHER: n-dodecyl-B-D-maltoside
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transfer Strategy in an Oocyte Donation Programme
Status: TERMINATED
Conditions: Oocyte Donation|Infertility, Female|Embryo Transfer
Interventions: PROCEDURE: Blastocyst-stage embryo transfer strategy|PROCEDURE: Cleavage-stage embryo transfer strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Changyanning Tablet for the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)
Status: NOT_YET_RECRUITING
Conditions: Diarrhea-Predominant Irritable Bowel Syndrome
Interventions: DRUG: Changyanning tablet|OTHER: Changyanning tablet placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Nonalcoholic Fatty Liver Disease in Children (TONIC)
Status: COMPLETED
Conditions: Fatty Liver
Interventions: DRUG: Metformin|DIETARY_SUPPLEMENT: Vitamin E|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hydrogen-oxygen Gas Mixture Inhalation in Patients With Sudden Sensorineural Hearing Loss
Status: UNKNOWN
Conditions: Hearing Loss, Sensorineural
Interventions: DEVICE: Hydrogen gas therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Timing of Intercostal Nerve Blocks During Video-Assisted Thoracic Surgeries
Status: COMPLETED
Conditions: Video-Assisted Thoracic Surgery|Video-Assisted Thoracoscopic Surgery
Interventions: DRUG: Normal Saline|DRUG: Ropivacaine|DRUG: Epinephrine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Two Different Blocks for Postoperative Analgesia in Patients Undergoing Unilateral Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Replacement, Total|Pain, Postoperative|Anesthesia, Regional
Interventions: DRUG: Bupivacaine Injection|DRUG: Bupivacaine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Blood Pressure Variability and the Prognosis of Ischemic Stroke With Intracranial Artery Stenosis
Status: UNKNOWN
Conditions: Blood Pressure Variability|Intracranial Artery Stenosis
Interventions: DRUG: Amlodipine|DRUG: ACEI / ARB|DRUG: Aspirin or Clopidogrel|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Once or Twice Daily Administration of BIIB021 to Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: BIIB021|DRUG: BIIB021
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Polyoxidonium, Nasal and Sublingual Spray, 6 mg/ml in Children Aged 1-12 Years With ARI
Status: COMPLETED
Conditions: Acute Respiratory Infection
Interventions: DRUG: Polyoxidonium 6 mg/ml|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Alveolar Rhabdomyosarcoma|Botryoid-Type Embryonal Rhabdomyosarcoma|Embryonal Rhabdomyosarcoma|Rhabdomyosarcoma|Sclerosing Rhabdomyosarcoma|Spindle Cell Rhabdomyosarcoma
Interventions: DRUG: Cyclophosphamide|BIOLOGICAL: Dactinomycin|DRUG: Irinotecan Hydrochloride|OTHER: Laboratory Biomarker Analysis|OTHER: Questionnaire Administration|RADIATION: Radiation Therapy|DRUG: Temsirolimus|DRUG: Vincristine Sulfate|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: APT001 Plasma/NO Generator to Treat Diabetic Foot Ulcer in Adults
Status: COMPLETED
Conditions: Foot Ulcer, Diabetic
Interventions: DEVICE: APT001|DEVICE: SHAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Carboplatin and ABI-007 in Treating Patients With Stage IV Melanoma That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: DRUG: carboplatin|DRUG: paclitaxel albumin-stabilized nanoparticle formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-Human Study of BBT-207 in Advanced Non-Small Cell Lung Cancer Harboring EGFR Mutation After Treatment With EGFR TKI
Status: RECRUITING
Conditions: EGFR Mutant Advanced Non-Small Cell Lung Cancer
Interventions: DRUG: BBT-207
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of a Single Oral Dose of MT-7117 on the QT/QTc Interval in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: MT-7117|DRUG: moxifloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Fetal Alcohol Spectrum Disorder : Clinical Description and Search for Epigenetic Biomarker (EPI-TSAF)
Status: RECRUITING
Conditions: Fetal Alcohol Spectrum Disorders
Interventions: DIAGNOSTIC_TEST: Extraction of microRNAs extracted from plasma (4 ml recovered as part of treatment)|DIAGNOSTIC_TEST: Extraction of microRNAs extracted from bucal swabs (act added for research).
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Kuvan on Neurocognitive Function, Blood Phenylalanine Level, Safety, and Pharmacokinetics in Children With PKU
Status: COMPLETED
Conditions: Phenylketonuria
Interventions: DRUG: sapropterin dihydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ProBio: A Biomarker Driven Study in Patients With Metastatic Prostate Cancer
Status: RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer (mCRPC)|Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
Interventions: DRUG: Enzalutamide Oral Capsule|DRUG: Abiraterone Oral Tablet|DRUG: Carboplatin|DRUG: Cabazitaxel 60 mg Solution for Injection|DRUG: Docetaxel Injectable Solution|DRUG: Radium Chloride Ra-223|DRUG: Niraparib plus Abiraterone acetate plus Prednisone|DRUG: Capivasertib plus Docetaxel|DRUG: Apalutamide|DRUG: Darolutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cultural Adaptation of Hap-pas-Hapi (Step-by-Step) for Albanian-speaking Immigrants in Switzerland and Germany
Status: TERMINATED
Conditions: Psychological Distress
Interventions: DEVICE: Hap-pas-Hapi
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of an Adventure-based Training Programme to Reduce Fatigue for Childhood Cancer Survivors
Status: COMPLETED
Conditions: Childhood Cancer
Interventions: BEHAVIORAL: health talk and adventure-based training|BEHAVIORAL: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Axillary Lymph Node Preservation Surgery in Reducing Lymphedema in Patients With Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: PROCEDURE: axillary lymph node dissection|DRUG: isosulfan blue based lymphatic mapping|PROCEDURE: axillary lymph node dissection|PROCEDURE: quality-of-life assessment|OTHER: Questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Motilitone on Gastric Accommodation in Healthy Adult Patients: Evaluation Using MRI Method
Status: COMPLETED
Conditions: Dyspepsia
Interventions: DRUG: Placebo (for Motilitone)|DRUG: Motilitone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ARQ 197 Plus Erlotinib in Patient With Locally Advanced or Metastatic EGFR Mutation-positive Non-small-cell Lung Cancer
Status: COMPLETED
Conditions: Non-small-cell Lung Cancer
Interventions: DRUG: ARQ 197
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Low-fat Vegan Dietary Intervention on Intracellular Lipid, Insulin Sensitivity, and Glycemic Control in Type 2 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Diabetes Mellitus Type 2 in Obese
Interventions: BEHAVIORAL: low-fat vegan diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of Gene-modified WT1 TCR Therapy in MDS & AML Patients
Status: COMPLETED
Conditions: Myelodysplastic Syndromes (MDS)|Acute Myeloid Leukaemia (AML)
Interventions: GENETIC: Autologous WT1 TCR transduced T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Therapeutic Strategies for Patients With Ewing's Sarcoma Family of Tumors, High Risk Rhabdomyosarcoma, and Neuroblastoma
Status: COMPLETED
Conditions: Ewing's Sarcoma|Neuroblastoma|Rhabdomyosarcoma
Interventions: DRUG: ADR-529|DRUG: Topotecan|DRUG: G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Association Between Local Cerebral Oxygenation Monitoring and Postoperative Delirium in Carotid Endarterectomy
Status: UNKNOWN
Conditions: Cerebral Oxygen Saturation|Postoperative Delirium|Carotid Endarterectomy
Interventions: DEVICE: local cerebral oxygen saturation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multi-Center Study Safety of Adipose Derived Mesenchymal Stem Cells for the Treatment of Multiple Sclerosis
Status: TERMINATED
Conditions: Multiple Sclerosis
Interventions: BIOLOGICAL: Autologous adipose derived mesenchymal cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Activity During Sexual Behavior in Patients With Primary Premature Ejaculation a Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: Premature Ejaculation
Interventions: DIAGNOSTIC_TEST: Detecting Brain Activity with Functional Near Infrared Spectroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Safety and Tolerability of Using SHR-1210 by Advanced Solid Tumor Subjects
Status: COMPLETED
Conditions: Solid Tumor|Breast Cancer|Gastrointestinal Cancer
Interventions: BIOLOGICAL: camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Music Therapy in the Treatment of Perioperative Anxiety and Pain
Status: COMPLETED
Conditions: Pain, Post Operative|Anxiety|Opioid Use
Interventions: OTHER: Music therapy|OTHER: Standard of Care Enhanced Recovery After Surgery (ERAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Nornicotine in Smokeless Tobacco as a Precursor for Carcinogen Exposure
Status: RECRUITING
Conditions: Smokeless Tobacco
Interventions: DRUG: Herbal Snuff (Smokeless Tobacco)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Stereotactic Radiosurgery and Erlotinib in Treating Patients With Non-Small Cell Lung Cancer and Brain Metastases
Status: WITHDRAWN
Conditions: Lung Cancer|Metastatic Cancer
Interventions: DRUG: erlotinib hydrochloride|OTHER: immunoenzyme technique|OTHER: laboratory biomarker analysis|OTHER: liquid chromatography|OTHER: mass spectrometry|OTHER: pharmacological study|RADIATION: stereotactic radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CBD (Cannabidiol) Intraoral Application and TMD (Temporomandibular Disorders)
Status: RECRUITING
Conditions: Temporomandibular Disorder|Myofascial Pain|Orofacial Pain|CBD|Bruxism
Interventions: COMBINATION_PRODUCT: 5% polymer gel with CBD application|COMBINATION_PRODUCT: 10% polymer gel with CBD application|COMBINATION_PRODUCT: Placebo intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced/Metastatic Solid Tumors|Colorectal Cancer|Gastric Cancer|Gastroesophageal-junction Cancer|NSCLC|HNSCC|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: MCLA-158|COMBINATION_PRODUCT: MCLA-158 + Pembrolizumab|COMBINATION_PRODUCT: MCLA-158 + FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of OMT on Premature Physiological Parameters
Status: UNKNOWN
Conditions: Premature Infant|Physiological Stress
Interventions: OTHER: osteopathic manipulative treatment|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Brief Behavioral Therapy for Insomnia (BBTI) in SUD Recovery
Status: RECRUITING
Conditions: Substance Use Disorders|Insomnia
Interventions: BEHAVIORAL: Brief Behavioral Therapy for Insomnia (BBTI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Similarity in Efficacy and Safety Between TRS003 and China-approved Bevacizumab® in NSCLC
Status: UNKNOWN
Conditions: Advanced Non-squamous Non-small-cell Lung Cancer
Interventions: BIOLOGICAL: TRS003|BIOLOGICAL: China-approved Bevacizumab|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Daily Blood Glucose Trends in Patients at Risk for Diabetes
Status: NOT_YET_RECRUITING
Conditions: Stress|Blood Sugar; High|Cholesterol, Elevated|Diet Habit
Interventions: DEVICE: 7-Day Continuous Glucose Monitoring with Abbott Freestyle Libre 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Insulin Deprivation and Hyperglycemia on Plasma Protein Synthesis in People With Type 1 Diabetes Mellitus
Status: NOT_YET_RECRUITING
Conditions: Type 1 Diabetes
Interventions: PROCEDURE: Muscle Biopsy|OTHER: Jell-O with Amino acids|DIETARY_SUPPLEMENT: Dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy of Voxilaprevir Plus Sofosbuvir/Velpatasvir Fixed Dose Combination in Adults With Chronic Genotype 1 HCV Infection
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: VOX|DRUG: SOF/VEL|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weekly Taxol Plus Xeloda® vs Taxotere q3wk Plus Xeloda® in the Treatment of Metastatic BC
Status: COMPLETED
Conditions: Breast Neoplasm
Interventions: DRUG: Paclitaxel weekly in combination with capecitabine|DRUG: Docetaxel every 3 week in combination with capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Colon Mucinous Adenocarcinoma|Colon Signet Ring Cell Adenocarcinoma|Rectal Mucinous Adenocarcinoma|Rectal Signet Ring Cell Adenocarcinoma|Recurrent Colon Carcinoma|Recurrent Rectal Carcinoma|Stage IVA Colon Cancer|Stage IVA Rectal Cancer|Stage IVB Colon Cancer|Stage IVB Rectal Cancer
Interventions: BIOLOGICAL: Cetuximab|DRUG: Gamma-Secretase Inhibitor RO4929097|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulsed Electromagnetic Field Therapy Versus Transcutaneous Electrical Nerve Stimulation in on Post-herpetic Neuralgia of the Sciatic Nerve
Status: COMPLETED
Conditions: Neuralgia,Postherpetic
Interventions: OTHER: Electromagnetic field therapy and transcutaneous electrical nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: N-acetylcysteine in Intra-amniotic Infection/Inflammation
Status: COMPLETED
Conditions: Labor, Premature|Preterm Premature Rupture of the Membranes|Infection|Inflammation|Chorioamnionitis
Interventions: PROCEDURE: amniocentesis|DRUG: N-acetylcysteine or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiographic and Histological Assessment of Autogenous Onlay Block Versus Cortical Shell on Anterior Maxilla
Status: RECRUITING
Conditions: Alveolar Bone Loss
Interventions: PROCEDURE: Autogenous onlay bone block harvesting from retromolar bone in anterior maxilla|PROCEDURE: Autogenous cortical shell technique from retromolar bone in anterior maxilla
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of Preoperative 3D Printed Stoma Placement on the Quality of Life of Ostomy Patients
Status: UNKNOWN
Conditions: Ostomy
Interventions: OTHER: Felt-tip marking|OTHER: Felt-tip marking + 3D printed ostomy button
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sleep Disorder Manage in Emotional Freedom Techniques vs Sleep Hygiene Education Group Therapy
Status: COMPLETED
Conditions: Sleep Disorder|Sleep Disorder in Elderly|Sleep Disorder, Mental Health|Sleep Disorders, Physical Health|Sleep Disorder; Insomnia Type|Sleep Hygiene
Interventions: BEHAVIORAL: The Sleep Hygiene Education (SHE)|BEHAVIORAL: Emotional Freedom Techniques (EFT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Impact of Autologous Platelet Rich Plasma on Healing of Rotator Cuff Repairs
Status: COMPLETED
Conditions: Rotator Cuff Pathology
Interventions: OTHER: Platelet Rich Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of H.P. Acthar Gel 80 U/ml to Improve the Signs and Symptoms in Subjects With Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: Corticotropin 80Unit/Ml Repository Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Applying an Artificial Intelligence-Enabled Electrocardiographic System for Reducing Mortality
Status: COMPLETED
Conditions: Cardiovascular Diseases|Intensity Care|Morality
Interventions: OTHER: AI-enabled ECG-based Screening Tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: A Study of AT-101 in Combination With Docetaxel in Squamous Cell Carcinoma Of The Head and Neck
Status: TERMINATED
Conditions: Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Interventions: DRUG: AT-101|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of SGN-B6A Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: sigvotatug vedotin|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Anesthesia With Computerized Device for Restorative Procedures in Pediatric Patients
Status: COMPLETED
Conditions: Dental Pain and Sensation Disorder|Dental Caries in Children
Interventions: DRUG: local anaesthetic injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zenith® p-Branch® and Zenith® Fenestrated AAA Endovascular Graft Clinical Study
Status: COMPLETED
Conditions: Aortic Aneurysm, Abdominal
Interventions: DEVICE: Zenith® p-Branch® or Zenith® Fenestrated AAA Endovascular Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer|Colorectal Cancer|Pancreatic Cancer|Solid Tumor|Shared Neoantigen-Positive Solid Tumors
Interventions: BIOLOGICAL: GRT-C903|BIOLOGICAL: GRT-R904|BIOLOGICAL: nivolumab|BIOLOGICAL: ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Participants With Chronic Low Back Pain
Status: COMPLETED
Conditions: Degenerative Disc Disease
Interventions: DRUG: Rexlemestrocel-L|DRUG: Rexlemestrocel-L + HA Mixture|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Olaparib Plus Pembrolizumab Versus Chemotherapy Plus Pembrolizumab After Induction With First-Line Chemotherapy Plus Pembrolizumab in Triple Negative Breast Cancer (TNBC) (MK-7339-009/KEYLYNK-009)
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple Negative Breast Neoplasms
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Olaparib|DRUG: Carboplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-arm, Open-label, Study to Assess the Pharmacokinetics of Darunavir and Ritonavir, Darunavir and Cobicistat, Etravirine, and Rilpivirine in HIV-1 Infected Pregnant Women
Status: COMPLETED
Conditions: HIV|HIV Infections|Pregnancy
Interventions: DRUG: Darunavir|DRUG: Ritonavir|DRUG: Etravirine|DRUG: Rilpivirine|DRUG: Darunavir/Cobicistat (FDC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telerobotic Ultrasound for Carotid Imaging - Feasibility Study
Status: WITHDRAWN
Conditions: Carotid Artery Disease|Atherosclerosis|Atheromatous Plaques|Arteriosclerosis|Vascular Disease|Arterial Occlusive Diseases|Stroke|Cardiac Death|Myocardial Infarction|Coronary Artery Disease|Cardiovascular Disease|Coronary Disease|Coronary Arteriosclerosis|Carotid Arteriosclerosis|Myocardial Ischemia|Heart Diseases|Cerebrovascular Disorders|Peripheral Vascular Disease|Cerebrovascular Accident|Cerebral Infarction
Interventions: RADIATION: Ultrasound for Carotid Arteries|RADIATION: Telerobotic Ultrasound for Carotid Arteries
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Blood Flow Restriction Training in Patients With Lower Extremity Fractures
Status: NOT_YET_RECRUITING
Conditions: Tibial Fractures|Lower Extremity Fracture
Interventions: DEVICE: Blood Flow Restriction with low load exercise|OTHER: Therapeutic Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myofascial Release Technique vs Posterior-anterior Glide on Non-specific Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Myofascial Release Experimental|OTHER: Posterior-Anterior Glide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of DSP107 Alone and in Combination With Atezolizumab for Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Non Small Cell Lung Cancer|Colorectal Cancer
Interventions: BIOLOGICAL: DSP107|BIOLOGICAL: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Prunella Oral Liquid in the Treatment of Thyroid Nodules
Status: NOT_YET_RECRUITING
Conditions: Thyroid Nodule
Interventions: DRUG: regular dose of JiRui® Prunella oral liquid|DRUG: 2x regular dose of JiRui® Prunella oral liquid|DRUG: regular dose of placebo|DRUG: 2x regular dose of placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Automation of Gamete Preparation, Intracytoplasmic Sperm Injection (ICSI), Embryo Culture, and Vitrification
Status: ACTIVE_NOT_RECRUITING
Conditions: Infertility
Interventions: DEVICE: Gamete preparation, ICSI, embryo culture and vitrification robot assistant|OTHER: Routine Manual ICSI Workflow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Micro-mobile Foot Compression and Diabetic Foot
Status: COMPLETED
Conditions: Diabetes|PAD|Lower Extremity Edema|Neuropathy;Peripheral|Foot Ulcer, Diabetic|Lymphatic Diseases
Interventions: DEVICE: Avex Footbeat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TeamBaby - Safe, Digitally Supported Communication in Obstetrics and Gynecology
Status: COMPLETED
Conditions: Pregnancy Related
Interventions: BEHAVIORAL: TeamBaby Online Communication Training (IG1) and TeamBaby Web-App Communication Training (IG2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Mobile Mental Health Apps for Suicide Prevention
Status: COMPLETED
Conditions: Depression|Anxiety|Emotional Regulation
Interventions: BEHAVIORAL: Mobile Mental Health App - 1|BEHAVIORAL: Mobile Mental Health App - 2|BEHAVIORAL: Mobile Mental Health App - 3|BEHAVIORAL: Mobile Mental Health App - 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Catheter Location on Postoperative Analgesia for Continuous Adductor Canal and Popliteal-Sciatic Nerve Blocks
Status: COMPLETED
Conditions: Post-surgical Pain|Total Knee Arthroplasty|Foot/Ankle Surgery|Catheterization for Postop Analgesia
Interventions: DRUG: ropivacaine 0.2%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Radiological Outcomes of Medacta Shoulder System (BE)
Status: RECRUITING
Conditions: Primary Osteoarthritis|Secondary Osteoarthritis|Rotator Cuff Tear Arthropathy|Rheumatoid Arthritis Shoulder|Avascular Necrosis|Fracture|Revision of Shoulder Arthroplasty
Interventions: DEVICE: Medacta Shoulder System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Osteopathic Treatment for Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain|Osteopathic Manipulative Treatment
Interventions: OTHER: G1 - Thrust manipulation|OTHER: G2 - Muscle Energy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Mobile Neurofeedback for ADHD Youth
Status: UNKNOWN
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DEVICE: mobile neurofeedback|DEVICE: Sham mobile neurofeedback|DEVICE: medication + mobile neurofeedback|DEVICE: medication + Sham mobile neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Phosphodiesterase Inhibitors in Incretin Secretion
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: Placebo|OTHER: Roflumilast/Sitagliptin|OTHER: Sitagliptin|OTHER: Roflumilast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Case-management Rehabilitation Intervention in Facilitating Return to Work After Myocardial Infarction
Status: COMPLETED
Conditions: Case Manager|Myocardial Infarction|Sick Leave|Return to Work
Interventions: PROCEDURE: Rehabilitation program group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Screening for Atrial Fibrillation in Elderly Women Older Than 70 Years
Status: RECRUITING
Conditions: Atrial Fibrillation New Onset
Interventions: DEVICE: Wearable cardiac monitor -Zio patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial Comparing the Efficacy and Safety of HR17031 Injection to INS068 Injection and to SHR20004 Injection in Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: HR17031 injection|DRUG: INS068 injection|DRUG: SHR20004 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sublingual Immunotherapy In Alternaria-Induced Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis (w/w Asthma) Due to Alternaria Alternata
Interventions: BIOLOGICAL: sublingual immunotherapy|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized Responses to Dietary Composition Trial 3
Status: RECRUITING
Conditions: Diabetes|Heart Diseases|Diet Habit|Diet Modification|Healthy|Obesity|Metabolism|Microbial Colonization
Interventions: OTHER: Dietary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial for Evaluation of Ethnic Differences in Pharmacokinetics of Chloroquine, an Anti-malarial Drug
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: chloroquine phosphate 1000 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of the Application of Lidocaine With Intraperitoneal Bupivacaine in Cesarian Operations Wound Infiltration
Status: UNKNOWN
Conditions: Postoperative Pain|Cesarean Section
Interventions: OTHER: Intraperİtoneal local anaesthesİc İn cesarean sectİon|OTHER: Local wound infiltrasyon|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: nHFOV vs nCPAP: Effects on Gas Exchange for the Treatment of Neonates Recovering From RDS
Status: COMPLETED
Conditions: Respiratory Distress Syndrome|Preterm Birth
Interventions: DEVICE: Medin-cno
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Of M-TAPA and TAP Block Following Laparoscopic Cholecystectomy
Status: RECRUITING
Conditions: Cholecystitis
Interventions: OTHER: Modified Perichondral Approach Thoracoabdominal Nerve block|OTHER: Transversus Abdominal Plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or Testes
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: filgrastim|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: dexamethasone|DRUG: etoposide|DRUG: leucovorin calcium|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: pegaspargase|DRUG: therapeutic hydrocortisone|DRUG: vincristine sulfate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnosis Accuracy of Abdominal Compression and Hemoconcentration to Detect Diuretic Induced Fluid Removal Intolerance.
Status: UNKNOWN
Conditions: Hypovolemia|Diuretic Toxicity|Fluid Overload
Interventions: DIAGNOSTIC_TEST: Abdominal compression (AC)|DIAGNOSTIC_TEST: blood sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p