pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Clinical Outcomes of Transvaginal Mesh Procedures for Cystocele Repair: Comparisons of Uphold and Perigee Systems
Status: COMPLETED
Conditions: Pelvic Organ Prolapse|Surgical Mesh
Interventions: PROCEDURE: Uphold|PROCEDURE: Perigee
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Feasibility of Endoscopic Ultrasound Based Biliary Stone Removal Without Fluoroscopy
Status: COMPLETED
Conditions: Common Bile Duct Gall Stones
Interventions: PROCEDURE: Common bile duct stone removal without fluoroscopy.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A CpG-methylation-based Assay for Stratifying Stage III Clear Cell Renal Cell Carcinoma of Receiving Adjuvant Treatment
Status: NOT_YET_RECRUITING
Conditions: Renal Neoplasms|Targeted Molecular Therapy
Interventions: DRUG: sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: More Complete Removal of Malignant Brain Tumors by Fluorescence-Guided Surgery
Status: WITHDRAWN
Conditions: Benign Neoplasms, Brain|Brain Cancer|Brain Neoplasms, Benign|Brain Neoplasms, Malignant|Brain Tumor, Primary|Brain Tumor, Recurrent|Brain Tumors|Intracranial Neoplasms|Neoplasms, Brain|Neoplasms, Intracranial|Primary Brain Neoplasms|Primary Malignant Brain Neoplasms|Primary Malignant Brain Tumors|Gliomas|Glioblastoma
Interventions: DRUG: 5-ALA (Gliolan)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics,and Antiviral Activity of RV299 Against Respiratory Syncytical Virus (RSV)
Status: COMPLETED
Conditions: Respiratory Syncytial Virus (RSV)
Interventions: DRUG: RV299|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Feasibility and Safety Study of Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy for CD19+CD22+ Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukemia|Lymphoma
Interventions: BIOLOGICAL: Patient-derived CD19- and CD22 specific CAR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TAK-341 in Treatment of Multiple System Atrophy
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple System Atrophy
Interventions: DRUG: TAK-341|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lifestyles and Breast Cancer
Status: RECRUITING
Conditions: Malignant Tumor of Breast
Interventions: BEHAVIORAL: Mediterranean diet supplemented with extra-virgin olive oil|BEHAVIORAL: Low-fat diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety Study of TRx0237 in Patients Already Taking Medications for Mild and Moderate Alzheimer's Disease
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: TRx0237|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-Pharmaceutical Treatment of Seasonal Allergic Conjunctivitis
Status: COMPLETED
Conditions: Hypersensitivity
Interventions: OTHER: Artificial Tear Supplement|DEVICE: Cold compress|DRUG: Anti-allergic Medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness Trial to Evaluate Protection of Pregnant Women by Hepatitis E Vaccine in Bangladesh.
Status: COMPLETED
Conditions: Hepatitis E Infection
Interventions: DRUG: Hecolin|DRUG: Hepa-B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Doxycycline to Treat Mansonella Perstans Infection in Patients With and Without Lymphatic Filariasis
Status: COMPLETED
Conditions: Mansonella Perstans Infection|Mp Microfilaremia
Interventions: DRUG: Doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Fludarabine Based RIC for Bone Marrow Failure Syndromes
Status: RECRUITING
Conditions: Bone Marrow Failure Syndromes
Interventions: OTHER: MRD-BMT with Fludarabine-based RIC for Acquired AA|OTHER: MRD-BMT with Fludarabine-based RIC for iBMF with trilineage aplasia|OTHER: MRD-BMT with Fludarabine-based RIC for iBMF without trilineage aplasia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: European Study Evaluating the EMBLOK Embolic Protection System During TAVR
Status: COMPLETED
Conditions: Aortic Valve Disease
Interventions: PROCEDURE: Transcatheter Aortic Valve Replacement (TAVR)|DEVICE: EMBLOK filter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Reverse Total Shoulder Arthroplasty Versus Hemiarthroplasty for Displaced 3- and 4-part Proximal Humeral Fractures
Status: COMPLETED
Conditions: Humeral Fracture, Proximal
Interventions: PROCEDURE: Reverse Total Shoulder Arthroplasty|PROCEDURE: Hemiarthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Glembatumumab Vedotin Following Doxorubicin and Cytoxan as Neo-adjuvant Therapy in Gp-NMB-expressing High Risk Triple Negative Breast Cancer
Status: WITHDRAWN
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Glembatumumab Vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Imaging in Staging of Primary Prostate Cancer
Status: COMPLETED
Conditions: High Risk Prostate Cancer
Interventions: DIAGNOSTIC_TEST: Whole body contrast enhanced computer tomography|DIAGNOSTIC_TEST: 99mTC-HMDP planar bone scintigraphy (BS)|DIAGNOSTIC_TEST: 99mTc-HMDP single photon emission computer tomography/computer tomography|DIAGNOSTIC_TEST: Whole-body magnetic resonance imaging|DIAGNOSTIC_TEST: Fluorine-18-prostate specific membrane antigen-1007- positron emission tomography/computer tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of PEGASYS (Peginterferon Alfa-2a [40KD]) in Patients With Hepatitis B e Antigen (HBeAg)-Negative Chronic Hepatitis B Virus (HBV)
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Peginterferon alfa-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of COPD Standardized Management on COPD Exacerbation
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: Standardized COPD management|OTHER: Routine COPD management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Aliskiren vs Hydrochlorothiazide in Hypertensive Type II Diabetic Patients on Resistance Arteries
Status: WITHDRAWN
Conditions: Hypertension|Diabetes
Interventions: DRUG: Aliskiren vs. hydrochlorothiazide|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Handheld Ultrasound-guided Cannulation of Difficult Haemodialysis Arteriovenous Access by Renal Nurses
Status: COMPLETED
Conditions: Hemodialysis Complication|Dialysis; Complications|Vascular Access Site Haematoma|Vascular Access Complication|Dialysis Access Malfunction|Fistula|Graft Av
Interventions: DEVICE: Handheld US device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transobturator Subtrigonal Tape vs Transobturator Suburethral Tape for Stress Urinary Incontinence
Status: UNKNOWN
Conditions: Stress Urinary Incontinence
Interventions: PROCEDURE: transobturator subtrigonal tape S-TOT|PROCEDURE: Transobturator suburethral tape (TOT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tumescence in HNC Skin Graft Reconstruction
Status: RECRUITING
Conditions: Head and Neck Cancer|Surgery--Complications|Graft Failure
Interventions: PROCEDURE: Tumescence During STSG Harvest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Cook Custom Aortic Endograft, the Zenith t-Branch Endovascular Graft, and Surgeon-Modified Endograft in Treating Aortic Pathologies
Status: RECRUITING
Conditions: Juxtarenal Aortic Aneurysm|Suprarenal Aortic Aneurysm|Thoracoabdominal Aortic Aneurysm|Penetrating Aortic Ulcer
Interventions: DEVICE: Cook Custom Aortic Endograft|DEVICE: Zenith t-Branch Endovascular Graft|DEVICE: Surgeon-Modified Endograft
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Three Dietary Regimens in Pre-colonoscopic Bowel Preparation in Children
Status: RECRUITING
Conditions: Bowel Preparation
Interventions: DIETARY_SUPPLEMENT: Liquid diet group|DIETARY_SUPPLEMENT: Enteral nutrition group|DIETARY_SUPPLEMENT: Low residual diet group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Permanent Intracranial Stenting for Acute Ischemic Stroke Related to a Refractory Large Vessel Occlusion
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DEVICE: Intracranial stenting|OTHER: Optimal medical care, without additional endovascular procedures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-time Neuromuscular Control of Exoskeletons
Status: RECRUITING
Conditions: Stroke
Interventions: OTHER: Isometric contractions|OTHER: Isokinetic contractions|DEVICE: Dynamic contractions|DEVICE: Isometric contraction with muscle fatigue|DEVICE: Multi-joint functional activities while wearing exoskeleton|OTHER: Clinical Assessments
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of L. Rhamnosus Yoba on RTI and Other Health Outcomes Among Children (3-6 Years) in Uganda
Status: COMPLETED
Conditions: Respiratory Tract Infections|Diarrhea|Skin Diseases|Tinea Capitis|Common Cold
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluate the Clinical Equivalence of Two Naftifine HCl 1% Creams in Patients With Interdigital Tinea Pedis
Status: COMPLETED
Conditions: Tinea Pedis
Interventions: DRUG: Naftifine HCl Cream 1%|DRUG: Naftin® (Naftifine HCl) Cream 1%|DRUG: Placebo topical cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 30-Week Extension to an Initial Combination Study (24 Weeks in Duration) of Sitagliptin With Pioglitazone (0431-064)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin 100 mg q.d.+ Pioglitazone 45 mg q.d.|DRUG: Pioglitazone 45 mg q.d. + Sitagliptin 100 mg placebo q.d.|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Is the Reduction in IOP After Treatment of 180 Degrees Equivalent to Treatment of 360 Degrees With SLT?
Status: COMPLETED
Conditions: Ocular Hypertension|Primary Open Angle Glaucoma of Both Eyes|Intraocular Pressure
Interventions: DEVICE: Selective laser trabeculoplasty (SLT)|PROCEDURE: Selective laser trabeculoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Novel Management of Airway Protection in Parkinson's Disease: A Clinical Trial
Status: COMPLETED
Conditions: Parkinson's Disease|Dysphagia|Dystussia
Interventions: DEVICE: EMST|BEHAVIORAL: smTAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of a FAI Insert in Subjects With Chronic Non-infectious Posterior Uveitis
Status: COMPLETED
Conditions: Posterior Uveitis|Intermediate Uveitis|Panuveitis
Interventions: DRUG: Sham Injection|DRUG: FAI Insert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Tranexamic Acid Versus Adrenaline During Flexible Bronchoscopy
Status: RECRUITING
Conditions: Bleeding|Hemoptysis
Interventions: DRUG: Tranexamic acid|DRUG: Adrenaline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Study of Nimotuzumab in Combination With Neoadjuvant Chemotherapy for Cervical Cancer
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: BIOLOGICAL: Nimotuzumab|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: APR-246 in Combination With Azacitidine for TP53 Mutated AML (Acute Myeloid Leukemia) or MDS (Myelodysplastic Syndromes) Following Allogeneic Stem Cell Transplant
Status: COMPLETED
Conditions: Acute Myeloid Leukemia or Myelodysplastic Syndromes
Interventions: DRUG: APR-246
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Near-Continuous, Noninvasive Blood Pressure Monitoring to Improve Outcomes in Pediatric Transport
Status: TERMINATED
Conditions: Pediatric Patients With SIRS (Systemic Inflammatory Response Syndrome)
Interventions: DEVICE: Continuous blood pressure monitoring using (Dinamap) standard oscillometric blood pressure device|DEVICE: Standard of care blood pressure monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Advancing Nursing Practices in Hospital Oncology Care
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastrointestinal Cancer|Gastrointestinal Disease|Nurse's Role
Interventions: BEHAVIORAL: Partnership, Assessment, Care and Transition training intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Modafinil, Sleep, and Cognition in Cocaine Dependence
Status: COMPLETED
Conditions: Cocaine Dependence|Substance-induced Sleep Disorder|Substance-induced Cognitive Disorder
Interventions: DRUG: Modafinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Study Assessing the Safety and Effectiveness of FEX60/PE10 Fixed Combination Tablet in Patients With Allergic Rhinitis
Status: COMPLETED
Conditions: Rhinitis Allergic
Interventions: DRUG: FEX60/PE10
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Veliparib and Topotecan With or Without Carboplatin in Treating Patients With Relapsed or Refractory Acute Leukemia, High-Risk Myelodysplasia, or Aggressive Myeloproliferative Disorders
Status: ACTIVE_NOT_RECRUITING
Conditions: Adult Acute Megakaryoblastic Leukemia|Adult Acute Monoblastic Leukemia|Adult Acute Monocytic Leukemia|Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With Maturation|Adult Acute Myeloid Leukemia With Minimal Differentiation|Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1|Adult Acute Myeloid Leukemia With t(9;11)(p21.3;q23.3); MLLT3-KMT2A|Adult Acute Myeloid Leukemia Without Maturation|Adult Acute Myelomonocytic Leukemia|Adult Erythroleukemia|Adult Pure Erythroid Leukemia|Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive|Chronic Myelomonocytic Leukemia|De Novo Myelodysplastic Syndrome|Essential Thrombocythemia|Hematopoietic and Lymphoid Cell Neoplasm|Myelodysplastic Syndrome|Polycythemia Vera|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Secondary Myelodysplastic Syndrome
Interventions: DRUG: Carboplatin|OTHER: Laboratory Biomarker Analysis|DRUG: Topotecan Hydrochloride|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy of Ketamine in Pediatric Patients With Idiopathic Scoliosis After Surgery
Status: COMPLETED
Conditions: Progressive Infantile Idiopathic Scoliosis
Interventions: DRUG: Ketamine Hydrochloride|OTHER: Placebo|DRUG: Remifentanil|DRUG: Morphine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nephrospec Switzerland
Status: RECRUITING
Conditions: Chronic Kidney Diseases|Hypertension
Interventions: DEVICE: NephrospecTM, low-intensity extracorporal shockwave therapy device|DEVICE: Sham-Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-proliferative Diabetic Retinopathy Treated With Runcaciguat
Status: COMPLETED
Conditions: Diabetic Retinopathy
Interventions: DRUG: Runcaciguat (BAY1101042)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Clinical Trial of Neoadjuvant Chemotherapy With/Without SPIONs/SMF for Patients With Osteosarcoma
Status: UNKNOWN
Conditions: Osteosarcoma
Interventions: DRUG: neoadjuvant chemotherapy+SPIONs/SMF|DRUG: neoadjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study To Compare Safety and Pharmacokinetic Properties of Surfolase Capsule and HT-002-01 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Surfolase capsule|DRUG: HT-002-01
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Immune Response to an Investigational Dengue Type 1 Vaccine
Status: COMPLETED
Conditions: Dengue Virus
Interventions: BIOLOGICAL: Investigational Vaccine for DEN1|OTHER: Placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Safety and Equivalence of Generic Azelaic Acid Foam and Finacea® Foam in Participants With Rosacea
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: Generic Azelaic Acid Foam|DRUG: Finacea® (Azelaic Acid) Foam|DRUG: Vehicle Foam|OTHER: Cleanser|OTHER: Sunscreen|OTHER: Towel|OTHER: Moisturizing Lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evolution of Myofascial Pain, Post-dry Needling. Repair and Measuring With Elastography, of Myofascial Tissue.
Status: COMPLETED
Conditions: Myofascial Pain Syndromes|Dry Needling, Technique for the Treatment of the Myofascial Trigger Points|Elastography
Interventions: OTHER: High Intensity Dry Needling|OTHER: Low intensity Dry Needling|OTHER: Fascial Mechanotransduction Dry Needling|OTHER: Technique Placebo of Dry Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing 4 Cycles With 6 Cycles of TC (Docetaxel+Cyclophosphamide) Adjuvant Chemotherapy for 1-3 Lymph Node Positive ER+/HER2- Early Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Docetaxel|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Bright Light Therapy on Migraine With Sleep Disturbance
Status: UNKNOWN
Conditions: Migraine|Sleep Disturbance
Interventions: DEVICE: Feel Bright Light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Renoprotective Effects of Dulaglutide in Patients With Type 2 Diabetic Nephropathy
Status: COMPLETED
Conditions: Type 2 Diabetic Nephropathy
Interventions: DRUG: Dulaglutide Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reproducibility and Accuracy of a Portable System for Early Detection of Cardiac Dysfunction in Childhood Cancer Survivors
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: PROCEDURE: Echocardiogram Recording|OTHER: Questionnaire Administration|PROCEDURE: Stress Cardiac Magnetic Resonance Imaging|DEVICE: Wireless Synchronized Cardiac Function Monitoring Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Pivotal Study of eCoin for Overactive Bladder With Urgency Urinary Incontinence
Status: ACTIVE_NOT_RECRUITING
Conditions: Overactive Bladder|Urge Incontinence|Incontinence, Urinary|Urinary Urge Incontinence
Interventions: DEVICE: eCoin Tibial Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study of 60 mg Nifedipine Extended Release Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Nifedipine Extended Release tablets 60 mg, single dose|DRUG: ADALAT® CC Extended Release Tablets 60 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Safety, Efficacy, and PK of Topical Paromomycin/Gentamicin Cream for Treatment of Cutaneous Leishmaniasis
Status: TERMINATED
Conditions: Leishmaniasis, Cutaneous
Interventions: DRUG: WR 279,396
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UNiD 3D VBR Register
Status: COMPLETED
Conditions: Spinal Cord Compression|Spondylosis|Ossification of Posterior Longitudinal Ligament|Spinal Neoplasms|Bone Disease, Infectious
Interventions: DEVICE: UNiD 3D VBR
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetics (PK) of Rilzabrutinib (PRN1008) in Healthy Japanese and Caucasian Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Rilzabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Fenugreek on Milk Production
Status: TERMINATED
Conditions: Lactation
Interventions: DRUG: fenugreek|DRUG: Placebo (Psyllium)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Optimal Time to Put Laryngeal Mask Airway in the Mouth Under General Anesthesia
Status: COMPLETED
Conditions: General Anesthesia
Interventions: PROCEDURE: Insertion of Laryngeal Mask Airway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Memory and Exercise Training Study in Older Adults With Subjective Memory Complaints
Status: COMPLETED
Conditions: Memory Impairment
Interventions: OTHER: simultaneous aerobic exercise|OTHER: sequential aerobic exercise|OTHER: stretching and toning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Alternatives to Dental Opioid Prescribing After Tooth Extraction
Status: ENROLLING_BY_INVITATION
Conditions: Analgesics, Opioid|Acute Pain|Tooth Extraction|Adolescent|Acetaminophen|Ibuprofen
Interventions: BEHAVIORAL: Multicomponent intervention|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Interaction of Buprenorphine With HIV Medications and Tuberculosis Medications
Status: COMPLETED
Conditions: Opioid Dependency|HIV Infections
Interventions: DRUG: Fosamprenavir/Ritonavir|DRUG: Darunavir/Ritonavir|DRUG: Rifampin|DRUG: Rifabutin|DRUG: Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of New Combination Inhaler (FlutiForm HFA MDI 100/10 µg) Versus Fluticasone and Formoterol Administered Alone, and Placebo, in Patients With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone propionate/formoterol fumarate 100/10|DRUG: Fluticasone propionate 100|DRUG: Formoterol fumarate 10|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ACL Reconstruction With Shark Screw® or Biocomposite-interference Screws
Status: NOT_YET_RECRUITING
Conditions: Anterior Cruciate Ligament Rupture|Anterior Cruciate Ligament Reconstruction|Anterior Cruciate Ligament Injury
Interventions: PROCEDURE: ACL reconstruction with Shark Screw ACL®|PROCEDURE: ACL reconstruction with biocomposite screw (Mecta)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Characterizing Upper Airway Collapse to Guide Patient Selection for Oral Appliance Therapy for Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DEVICE: Oral appliance|DEVICE: BluePro oral appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Radiation Therapy Alone Versus Radiation Therapy Plus Radiofrequency Ablation (RFA)/Vertebral Augmentation
Status: RECRUITING
Conditions: Oncology|Spine Metastases
Interventions: RADIATION: Radiation Therapy|RADIATION: Radiofrequency Ablation (RFA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Radiation Eliminates Storming Cytokines and Unchecked Edema as a 1-Day Treatment for COVID-19
Status: TERMINATED
Conditions: Pneumonia|Coronavirus Infection in 2019 (COVID-19)|Severe Acute Respiratory Syndrome (SARS) Pneumonia
Interventions: RADIATION: Low Dose Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Using Noninvasive Ventilation Associated With Recruitment Maneuver in Cardiac Surgery.
Status: COMPLETED
Conditions: Hypoxia
Interventions: OTHER: recruitment group (RG)|OTHER: control group (CG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study to Evaluate Safety, Tolerability, Anti-Tumour Activity and PK Profiles of Foxy-5 in Metastatic Breast, Colon or Prostate Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer|Colorectal Cancer|Prostate Cancer
Interventions: DRUG: Foxy-5
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feeding Bovine Colostrum to Preterm Infants
Status: COMPLETED
Conditions: Feeding Intolerance|Extrauterine Growth Retardation|Necrotizing Enterocolitis|Sepsis|Meningitis
Interventions: DIETARY_SUPPLEMENT: Bovine colostrum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of E7050 in Combination With E7080 in Participants With Advanced Solid Tumors (Dose Escalation) and in Participants With Recurrent Glioblastoma or Unresectable Stage III or Stage IV Melanoma After Prior Systemic Therapy (Expansion Cohort and Phase 2)
Status: TERMINATED
Conditions: Advanced Solid Tumors
Interventions: DRUG: Golvatinib|DRUG: Lenvatinib|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of TPX-0046, A RET/SRC Inhibitor in Adult Subjects With Advanced Solid Tumors Harboring RET Fusions or Mutations
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer|Medullary Thyroid Cancer|RET Gene Mutation|Metastatic Solid Tumor|Advanced Solid Tumor
Interventions: DRUG: TPX-0046
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CBT-I on Alcohol Treatment Outcomes Among Veterans
Status: COMPLETED
Conditions: Insomnia|Alcohol Use Disorder
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia|BEHAVIORAL: Sleep Hygiene|BEHAVIORAL: Alcohol Use Disorder Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Food Upon Pharmacokinetics of Single Oral Dose of Cediranib (AZD2171, Recentin™)
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Cediranib|DRUG: Cediranib 30 - 90 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Methylphenidate Versus Sustained Release Methylphenidate on Cognitive Functioning
Status: TERMINATED
Conditions: Brain Tumor
Interventions: DRUG: IR Methylphenidate|DRUG: Modafinil|DRUG: SR Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Benefit of Arthroscopic Partial Meniscectomy in Middle-Aged Patients
Status: TERMINATED
Conditions: Degenerative Meniscus Tear
Interventions: PROCEDURE: Arthroscopic partial meniscectomy|PROCEDURE: Sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Long-Term Renoprotection of Optimal Antiproteinuric Doses of Benazepril and Losartan in Chronic Renal Insufficiency
Status: TERMINATED
Conditions: Renal Insufficiency,Chronic|Disease Progression|Proteinuria|Dose-Response Relationship,Drug|ACE Inhibitor|Angiotensin II Type 1 Receptor Blockers
Interventions: DRUG: Benazepril|DRUG: Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two TraCer PositROn EmiSSion Tomography ComBination for Efficacy EstimatiOn of Prostate Specific Membrane Antigen Radioligand Therapy in Patients With Metastatic Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer|Prostate Adenocarcinoma|Prostatic Neoplasms|Metastatic Prostate Cancer|Metastatic Prostatic Adenocarcinoma|Metastatic Prostate Carcinoma in the Soft Tissue
Interventions: DRUG: 131I-PSMA-1095 Radioligand Therapy (RLT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid-Sparing Effects of Nurse-Delivered Hypnosis During Breast Cancer Surgery
Status: RECRUITING
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Group 1|BEHAVIORAL: Group 2|BEHAVIORAL: Group 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Itraconazole on the Pharmacokinetics of Pyrotinib in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: pyrotinib tablet|DRUG: Itraconazole capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Para-aortic Lymph Node Metastasis in Resectable Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreas Cancer|Pancreas Adenocarcinoma|Lymph Node Metastasis
Interventions: PROCEDURE: PALN resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Biosimilar Filgrastim on the Mobilization of Hematopoietic Stem Cell CD34+ (Cluster of Differentiation 34) and on the Kinetic Engraftment
Status: UNKNOWN
Conditions: Blood Diseases
Interventions: DRUG: FILGRASTIM
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cardiac MRI for Optimal Heart Failure Outcomes With CRT Upgrades
Status: UNKNOWN
Conditions: Chronic Systolic Heart Failure|Paroxysmal VT
Interventions: DIAGNOSTIC_TEST: MRI prior to CRT Upgrade|DIAGNOSTIC_TEST: MRI prior to de novo CRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect Of High And Low Molecular Weight Sodium Hyaluronic Acid Eye Drops After Crosslinking
Status: COMPLETED
Conditions: Keratoconus
Interventions: DEVICE: in vivo Corneal Confocal Microscopy|DIAGNOSTIC_TEST: Corneal Sensitivity|DEVICE: Non invasive tear break up time|DIAGNOSTIC_TEST: Ocular Surface Disease Index Qestionnaire|DEVICE: Corneal tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reducing Asymmetry During Gait Using the TPAD (Tethered Pelvic Assist Device) for Stroke Patients
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: TPAD (Tethered Pelvic Assist Device)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Radiological Evaluation of Patients With Vertebrobasilar Insufficiency in Assiut University Hospital
Status: UNKNOWN
Conditions: Vertebrobasilar Insufficiency
Interventions: DEVICE: transcranial doppler
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Safety and Dosimetry Study of 177Lu-LNC1003 Injection
Status: NOT_YET_RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer, mCRPC
Interventions: DRUG: 177Lu-LNC1003 Injection group 1|DRUG: 177Lu-LNC1003 Injection group 2|DRUG: 177Lu-LNC1003 Injection group 3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reliability and Validity of the IASP Clinical Criteria for Identifying Patients With Nociplastic Pain
Status: RECRUITING
Conditions: Chronic Pain|Central Sensitisation|Nociplastic Pain
Interventions: DIAGNOSTIC_TEST: Algo(s)rithm/ IASP clinical criteria|DIAGNOSTIC_TEST: Pressure Pain Threshold
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Complete Decongestive Therapy in Breast Cancer-Related Lymphedema
Status: WITHDRAWN
Conditions: Lymphedema of Upper Limb
Interventions: OTHER: Standard of care complete decongestive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Three Experimental Toothpastes to Remove Plaque
Status: COMPLETED
Conditions: Dental Plaque
Interventions: DRUG: 20% w/w sodium bicarbonate|DRUG: 35% w/w sodium bicarbonate|DRUG: 50% w/w sodium bicarbonate|DRUG: 67% w/w sodium bicarbonate|DRUG: 0% w/w sodium bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brief Intervention for Drug Misuse in the Emergency Department
Status: COMPLETED
Conditions: Substance Abuse Detection|HIV|Hepatitis B|Hepatitis C|Brief Intervention|HIV Infections
Interventions: BEHAVIORAL: Brief motivational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Culturally-adapted Diabetes Prevention Lifestyle Intervention for Latinos (E-LITE Latinos)
Status: COMPLETED
Conditions: Prediabetic State|Metabolic Syndrome X|Insulin Resistance
Interventions: BEHAVIORAL: Vida Sana|OTHER: Usual Care Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Long Term Safety and Efficacy Study of Tolebrutinib (SAR442168) in Participants With Relapsing Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: Tolebrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Inhaled Nitric Oxide (iNO) on Ischemia / Reperfusion Injury During Orthotopic Liver Transplantation With Marginal Grafts
Status: UNKNOWN
Conditions: Liver Transplant
Interventions: PROCEDURE: Inhaled Nitric Oxide (iNO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Flexible Intubation Scope with or Without Video Laryngoscope in Supporting Endotracheal Tube Placement in Patients with Head and Neck Cancer Before Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Neoplasm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Health Improvement Through Food and Lifestyle Intervention Based On Personalized Retail Advice
Status: UNKNOWN
Conditions: Metabolic Syndrome|Gut Bacteria|Personalized Nutrition
Interventions: OTHER: Microbiota modulation diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prospective Multicenter Study on the Identification of Genetic Abnormalities Predisposing to Vasospasm From a Privileged Model: the Primary Raynaud's Phenomenon
Status: COMPLETED
Conditions: Primary Raynaud's Phenomenon (PR)|Genetic Mutations Causing PR|Study of Patients and Their Relatives (With or Without Primary PR)
Interventions: GENETIC: Demonstration of genetic mutations causing Raynaud's phenomenon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Tocolysis in Prevention of Preterm Labor
Status: UNKNOWN
Conditions: Preterm Labor Without Delivery
Interventions: DRUG: Magnesium Sulfate|DRUG: Ritodrine|DRUG: Calcium Channel Blockers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Phentermine/Topiramate in Youth With Hypothalamic Obesity
Status: RECRUITING
Conditions: Hypothalamic Obesity|Hypothalamic Tumor|Craniopharyngioma
Interventions: DRUG: Phentermine / Topiramate Extended Release Oral Capsule [Qsymia]|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Audio-visual Stimulation for Sleep Promotion in Older Adults With Osteoarthritis Pain
Status: COMPLETED
Conditions: Insomnia Chronic|Osteoarthritis|Pain, Chronic
Interventions: DEVICE: Audiovisual Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Mass Balance Recovery, Pharmacokinetics, Metabolite Profile and Metabolite Identification of [14C]AZD4831
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DRUG: 14C]AZD4831 Oral Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Assessing Godex Carnitine Orotate Complex in Nonalcoholic Fatty Liver Disease Patients for Efficacy
Status: ENROLLING_BY_INVITATION
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: DRUG: GODEX|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remote Ischemic Preconditioning and Risk of Contrast-Induced Acute Kidney Injury in Patients Undergoing Coronary Stent Implantation
Status: UNKNOWN
Conditions: Acute Kidney Injury
Interventions: PROCEDURE: remote ischemic preconditioning (RIPC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Biological Efficacy Study of TisssueGene-C to Degenerative Arthritis
Status: COMPLETED
Conditions: Degenerative Arthritis
Interventions: BIOLOGICAL: TissueGene-C(Low dose)|BIOLOGICAL: TissueGene-C(Medium dose)|BIOLOGICAL: TissueGene-C(High dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Fasting Study of Finasteride Tablets 5 mg and Proscar Tablets 5 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Finasteride Tablets 5 mg|DRUG: Proscar Tablets 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Safety and Effectiveness of Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Who Have Had PCP Before
Status: COMPLETED
Conditions: Pneumonia, Pneumocystis Carinii|HIV Infections
Interventions: DRUG: Pentamidine isethionate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Dose Finding Study of Namilumab in Combination With Methotrexate in Participants With Moderate to Severe Rheumatoid Arthritis (RA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Namilumab|DRUG: Placebo|DRUG: Methotrexate|DRUG: Folic/folinic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PET and CT Scans in Patients With Locally Advanced Primary Rectal Cancer That Can Be Removed During Surgery
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: chemotherapy|PROCEDURE: computed tomography|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|PROCEDURE: positron emission tomography|PROCEDURE: radionuclide imaging|RADIATION: fludeoxyglucose F 18|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessment of Compliance With Monitoring Conducted by a Physician in Person or by a Nurse in Remote Monitoring
Status: RECRUITING
Conditions: Stage I Testicular Seminoma|Stage I Testicular Nonseminomatous Germ Cell Tumor|Gastrointestinal Stromal Tumors|Ovarian Germ Cell Tumor|Adenocarcinoma, Clear Cell|Borderline Ovarian Tumor|Sex Cord-Stromal Tumor|Mucinous Adenocarcinoma of Ovary|Carcinoma, Small Cell|Carcinosarcoma, Ovarian|Serous Tumor of Ovary|Glioma|Neuroendocrine Tumors|Aggressive Fibromatosis of Abdominal Wall (Disorder)
Interventions: OTHER: Oncological Follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Investigate Safety, Tolerability, and Pharmacokinetics of JNJ 53718678 in Healthy Japanese Adult Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ 53718678|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Family Support Intervention in Intensive Care Units
Status: ACTIVE_NOT_RECRUITING
Conditions: Postintensive Care Syndrome|Family Members|Quality of Life|Depression, Anxiety|Posttraumatic Stress Disorder|Family Dynamics
Interventions: OTHER: Family Support Intervention (FSI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of MK0364 in Obese Patients (0364-014)
Status: TERMINATED
Conditions: Obesity
Interventions: DRUG: Comparator: taranabant|DRUG: Comparator: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT