pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: EVADRY® in the Treatment of Xerostomia in Sjögren's Syndrome
Status: NOT_YET_RECRUITING
Conditions: Sjogren's Syndrome
Interventions: DIETARY_SUPPLEMENT: EVADRY|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Optical Coherence Tomography to Determine the Optimal Management of Patients With Drug-eluting Stents Who Need Non-cardiac Surgery
Status: TERMINATED
Conditions: Coronary Stent Occlusion
Interventions: DEVICE: Optical coherence tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics and Safety of Gadopiclenol in Japanese Healthy Volunteers
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: gadopiclenol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Comparison of Two Strategies of Glucocorticoid Withdrawal in Rheumatoid Arthritis Patients
Status: COMPLETED
Conditions: RheumatoId Arthritis
Interventions: DRUG: GlucoCorticoid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comaprison of 68Ga-FAP-2286 and 18F-FDG PET/CT in Patients With Various Types of Cancer
Status: COMPLETED
Conditions: Tumor, Solid|Positron-Emission Tomography
Interventions: DIAGNOSTIC_TEST: 18F-FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase II Study of Cetuximab With or Without OSI-906 in Head and Neck Squamous Cell Carcinoma (HNSCC)
Status: WITHDRAWN
Conditions: Head and Neck Cancer
Interventions: DRUG: Cetuximab|DRUG: OSI-906|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Omega 3 Supplementation on the Heart Rate Variability in Obese Children
Status: RECRUITING
Conditions: Obesity, Childhood
Interventions: OTHER: Placebo|DIETARY_SUPPLEMENT: Omega 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaginal Laser Therapy in Breast Cancer Survivors
Status: UNKNOWN
Conditions: Genitourinary Syndrome of Menopause|Vaginal Atrophy|Breast Cancer|Dyspareunia
Interventions: DEVICE: Microablative Fractional CO2 Laser Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hybrid SA RGP Center/S-H Skirt Daily Wear 90 Day Multicenter Study
Status: COMPLETED
Conditions: Corneal Disease|Hypersensitivity
Interventions: DEVICE: SynergEyes Hybrid (petrafocon A hem-larafilcon A) Hybrid Contact Lens|DEVICE: SynergEyes Hybrid (paflufocon D hem-iberfilcon A) Contact Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect on Iron Levels by the Inclusion of Native Potato in the Diet of Children From 2 to 5 Years, ICBF Beneficiaries. Nariño. Colombia. Cluster Randomized Controlled Trial
Status: COMPLETED
Conditions: Effect on Iron Levels
Interventions: DIETARY_SUPPLEMENT: native potato
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Controlled Smoking Cessation Trial and Prospective Cohort Study of Tuberculosis (TB) Treatment Outcomes
Status: COMPLETED
Conditions: Smoking Cessation|Tuberculosis
Interventions: OTHER: Intensive anti-smoking counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TACE-HAIC vs. HAIC for Potentially Resectable HCC
Status: RECRUITING
Conditions: Potentially Resection|Hepatocellular Carcinoma
Interventions: DRUG: TACE-HAIC|DRUG: HAIC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transdiagnostic, Cognitive and Behavioral Intervention for in School-aged Children With Emotional and Behavioral Disturbances
Status: COMPLETED
Conditions: Anxiety|Anxiety Disorders|Depressive Symptoms|Depressive Disorders|Problem Behavior|Oppositional Defiant Disorder|Conduct Disorder|Other Behavioral and Emotional Disorders With Onset Usually Occurring in Childhood and Adolescence
Interventions: BEHAVIORAL: Mind My Mind (MMM)|BEHAVIORAL: Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Photodynamic Therapy in Pericoronitis
Status: ENROLLING_BY_INVITATION
Conditions: Pericoronitis
Interventions: COMBINATION_PRODUCT: irrigation /sterile saline|COMBINATION_PRODUCT: Conventional methylene blue as photosensitizer|COMBINATION_PRODUCT: Methylene blue for oral use as photosensitizer|COMBINATION_PRODUCT: Photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pimavanserin as Adjunctive Treatment for the Negative Symptoms of Schizophrenia (ADVANCE)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Pimavanserin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety, Tolerability, and Pharmacokinetics of REGN6490 in Healthy Japanese Adult Volunteers
Status: TERMINATED
Conditions: Healthy Volunteer
Interventions: DRUG: REGN6490|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prostate Cancer Genetic Risk Evaluation and Screening Study
Status: RECRUITING
Conditions: Prostatic Neoplasm|Prostate Cancer|BRCA2 Mutation|BRCA1 Mutation|ATM Gene Mutation|MMR Mutation|Lynch Syndrome|Genetic Predisposition to Disease
Interventions: DIAGNOSTIC_TEST: Prostate cancer screening
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Extension Study SCI-SCV-HCV-P2-001: Long-Term FU in Subj Who Opt for Retreatment With Peg-INF and RBV After Completing Treatment in HCV
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: SCV-07
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pregabalin Trial for the Treatment of Alcohol Use Disorder
Status: SUSPENDED
Conditions: Alcohol Use Disorder
Interventions: DRUG: Pregabalin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab (MK-3475) in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC)(MK-3475-199/KEYNOTE-199)
Status: COMPLETED
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Barriers and Facilitators to OTC Hearing Aids Success
Status: NOT_YET_RECRUITING
Conditions: Hearing Loss, Sensorineural|Presbycusis
Interventions: DEVICE: Audiologist-based fitting|DEVICE: Over-the-counter fitting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Functioning of Prospective Memory in Breast Cancer and the Influence of Sleep
Status: COMPLETED
Conditions: Breast Cancer|Memory Disorders
Interventions: OTHER: Neuropsychological, psycho-pathological and quality of life assessments|DRUG: Hormonotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cyclical Topical Wound Oxygen Therapy (TWO2) in the Treatment of Chronic Wounds
Status: UNKNOWN
Conditions: Evaluate the Efficacy of Cyclical Topical Wound Oxygen Therapy in the Treatment of Chronic Wounds
Interventions: DEVICE: AOTI Inc. TWO2 topical oxygen therapy equipment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study With Chondroitin Sulfate and Glucosamine Sulfate (in Dosage Capsule and Sachet) in Treating Osteoarthritis
Status: UNKNOWN
Conditions: Osteoarthritis
Interventions: DRUG: Chondroitin sulfate + Glucosamine sulfate|DRUG: Chondroitin sulfate + Glucosamine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PH-797804 Versus Placebo For The Treatment Of Neuropathic Pain Associated With Post-Herpetic Neuralgia
Status: COMPLETED
Conditions: Neuralgia, Postherpetic
Interventions: DRUG: PH-797804|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Imaging Study in Patients With Atherosclerosis Taking Rilapladib or Placebo for 12 Weeks
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DRUG: rilapladib|DRUG: placebo|OTHER: 18F Fluorodeoxylucose (FDG)-PET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate Multiple Ascending Oral Doses of AZD5213 in Healthy Male and Non Fertile Female Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD5213|DRUG: Placebo to AZD5213
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Drug Interaction Between Povorcitinib and the Oral Contraceptive Levonorgestrel/Ethinyl Estradiol in Healthy Adult Females
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Povorcitinib|DRUG: Levonorgestrel/Ethinyl estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allo HSCT Using RIC and PTCy for Hematological Diseases
Status: RECRUITING
Conditions: Acute Myelogenous Leukemia|Acute Lymphocytic Leukemia|Biphenotypic Acute Leukemia|Undifferentiated Leukemia|Prolymphocytic Leukemia|Chronic Myelogenous Leukemia|Plasma Cell Leukemia|Myelodysplastic Syndromes|Leukemia, Myeloid|Myelodysplastic Syndrome With Excess Blasts-1|Burkitt Lymphoma|Relapsed T-Cell Lymphoma|Relapsed Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|Marginal Zone Lymphoma|Follicular Lymphoma|Myeloproliferative Neoplasm|Myelofibrosis
Interventions: BIOLOGICAL: Peripheral Blood Stem Cell Transplant|DRUG: Allopurinol 300 MG|DRUG: Fludarabine|DRUG: Cyclophosphamide|BIOLOGICAL: Bone Marrow Cell Transplant|RADIATION: Total Body Irradiation|DRUG: Sirolimus Pill|DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Sujok Therapy on Symptom Burden and Comfort Level in Patients Undergoing Hemodialysis Treatment
Status: NOT_YET_RECRUITING
Conditions: Dialysis; Complications
Interventions: OTHER: Su Jok therapy|OTHER: placebo|OTHER: routine interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Serum Cysteine Rich Protein 61 and Cystatin C for Early Detection of Acute Kidney Injury in Patients With Heart Diseases
Status: NOT_YET_RECRUITING
Conditions: Acute Kidney Injury
Interventions: DIAGNOSTIC_TEST: Serum Cysteine Rich Protein 61
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preoperative Fluoroscopy Guided Hip Articular Branch Blocks and Analgesic Outcomes Following Hip Arthroscopy
Status: WITHDRAWN
Conditions: Surgery, Arthroscopic|Analgesia|Pain, Acute
Interventions: OTHER: Control|OTHER: Articular Branch Block (ABB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Visual Perceptual Learning for the Treatment of Visual Field Defect
Status: COMPLETED
Conditions: Visual Fields Hemianopsia|Hemianopsia, Homonymous
Interventions: DEVICE: Nunap Vision|DEVICE: Nunap Vision-C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Response Effect of Drop Jumps on Bone Characteristics
Status: COMPLETED
Conditions: Healthy Participants|Low Activity Level
Interventions: BEHAVIORAL: Diagonal Drop Jumps 0cm|BEHAVIORAL: Diagonal Drop Jumps 40cm|BEHAVIORAL: Diagonal Drop Jumps 60cm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Efficacy and Safety of Flumatinib in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase.
Status: RECRUITING
Conditions: CML, Chronic Phase
Interventions: DRUG: Flumatinib mesylate tablets (400mg)|DRUG: Flumatinib mesylate tablets (600mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neural Dynamics Technique for the Treatment of Chronic Radicular Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain|Sciatica
Interventions: PROCEDURE: neural dynamics techniques treatment|PROCEDURE: placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Extracorporeal Photopheresis (ECP) in the Treatment of Type 1 Diabetes Mellitus
Status: RECRUITING
Conditions: Type 1 Diabetes
Interventions: COMBINATION_PRODUCT: ECP regular-intensity arm|COMBINATION_PRODUCT: ECP accelerated-intensity arm|BIOLOGICAL: T1DM standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: J-Pouch Coloanal Anastomosis Compared With Side-to-End Coloanal Anastomosis After Radiation Therapy and Surgery to Remove the Rectum in Treating Patients With Rectal Adenocarcinoma
Status: UNKNOWN
Conditions: Colorectal Cancer|Perioperative/Postoperative Complications
Interventions: PROCEDURE: conventional surgery|PROCEDURE: management of therapy complications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Opioid Infusion Rate on Abuse Liability Potential of Intravenous Hydromorphone for Cancer Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: DRUG: Hydromorphone|DRUG: Placebo Administration|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: : A Phase Ib/II Study To Evaluate Fruquintinib Monotherapy Or Plus Sintilimab In Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: Fruquintinib in Combination with Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dosage-dependence of Graded Exercise Therapy in Patients With Patellofemoral Pain Syndrome.
Status: COMPLETED
Conditions: Patellofemoral Pain Syndrome
Interventions: BEHAVIORAL: High exercise therapy|BEHAVIORAL: Low exercise therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Capecitabine and Temozolomide in Combination to Lutetium Lu 177 Dotatate in Patients With Advanced Pancreatic Neuroendocrine Tumors
Status: RECRUITING
Conditions: Metastatic Pancreatic Neuroendocrine Tumor|Unresectable Pancreatic Neuroendocrine Carcinoma
Interventions: DRUG: Lutetium Lu 177 Dotatate|DRUG: Capecitabine|DRUG: Temozolomide|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effectiveness and Safety of Paliperidone Palmitate in Subjects With Acute Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Paliperidone palmitate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel, Carboplatin, and Bevacizumab With or Without Cixutumumab in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Large Cell Lung Carcinoma|Lung Adenocarcinoma|Recurrent Non-Small Cell Lung Carcinoma|Stage IV Non-Small Cell Lung Cancer|Bronchioloalveolar Lung Carcinoma
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Carboplatin|BIOLOGICAL: Cixutumumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioresorbable Glass Fiber Matrix in the Treatment of Diabetic Foot Ulcers
Status: RECRUITING
Conditions: Diabetic Foot Ulcer|Ulcer Foot|Diabetic Foot
Interventions: DEVICE: Mirragen Wound Matrix|DEVICE: Fibracol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Double Fortified Salt (DFS) to Improve Work Productivity in Women in India
Status: COMPLETED
Conditions: Anemia|Iron Deficiency
Interventions: OTHER: double fortified salt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transfusion of Prematures Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Infant, Newborn, Diseases|Infant, Extremely Low Birth Weight|Infant, Small for Gestational Age|Bronchopulmonary Dysplasia (BPD)|Anemia
Interventions: PROCEDURE: Liberal Cell Transfusion|PROCEDURE: Restricted red cell transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, School-based Effectiveness Trial of the Adolescent Depression Awareness Program
Status: COMPLETED
Conditions: Adolescent - Emotional Problem|Depression|Prevention Harmful Effects
Interventions: OTHER: Adolescent Depression Awareness Program (ADAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Testing of a D1 Agonist for Cognitive Enhancement in Schizotypal Personality Disorder
Status: UNKNOWN
Conditions: Cognitive Impairments|Schizotypal Personality Disorder
Interventions: DRUG: DAR-0100A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NAC as a Potential Treatment for Methamphetamine Dependence
Status: COMPLETED
Conditions: Methamphetamine Abuse|Methamphetamine Dependence|Substance Abuse
Interventions: DRUG: Placebo|DRUG: N-acetylcysteine|DRUG: N-acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Intrapleural Docetaxel Administration Using Medical Pleuroscopy in Malignant Effusion With Lung Cancer
Status: COMPLETED
Conditions: Pleural Effusion, Malignant|Non-small Cell Carcinoma
Interventions: DRUG: intrapleural docetaxel administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CIK Cell Therapy for Relapsed or Refractory Acute B-Lymphoblastic Leukemia: Prognostic Impact on Patients With Early CAR-T Cell Dysfunction
Status: NOT_YET_RECRUITING
Conditions: B-cell Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia, in Relapse|Refractory Acute Lymphoid Leukemia
Interventions: DRUG: peripheral blood lymphocytes|DRUG: CIK cell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography (PET) Study With [11C]AZD2995 and [11C]AZD2184, Candidate PET Ligands for β Amyloid
Status: COMPLETED
Conditions: Alzheimer´s Disease
Interventions: DRUG: Radioligand (11C)AZD2995|DRUG: Radioligand (11C)AZD2184
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phonoaudiologic Therapy Adjunct to Treatment on Patients With Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea Syndrome
Interventions: DEVICE: Continuous Positive Airway Pressure (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Education Video to Reduce OTC NSAIDs
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Kidney Diseases|Heart Failure|Hypertension
Interventions: BEHAVIORAL: Educational video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Double-blind, Placebo-controlled Study to Evaluate Very Low Dose LSD in Healthy Volunteers Aged 55-75 Years
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Lysergic acid diethylamide (LSD) 5µg|DRUG: Lysergic acid diethylamide (LSD) 10µg|DRUG: Lysergic acid diethylamide (LSD)20 µg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Can Life's Wisdom Help Counter Depression? Evaluating the CBT Timeline Approach for Older Adults With Depression
Status: COMPLETED
Conditions: Depression in Old Age
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy for older adults: wisdom enhancement 'timeline technique'
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Neuroscience Education Combined With Cognition-targeted Motor Control Training
Status: COMPLETED
Conditions: Chronic Spinal Pain
Interventions: OTHER: usual care evidence-based physiotherapy|OTHER: modern neuroscience approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis
Status: COMPLETED
Conditions: Lumbar Spinal Stenosis|Spondylolisthesis|Degenerative Disc Disease
Interventions: DEVICE: Minuteman Fusion Implant|PROCEDURE: surgical decompression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega-3, Nigella Sativa, Indian Costus, Quinine, Anise Seed, Deglycyrrhizinated Licorice, Artemisinin, Febrifugine on Immunity of Patients With (COVID-19)
Status: COMPLETED
Conditions: Covid19|Immunodeficiency
Interventions: DRUG: Omega 3/Nigella Sativa Oil|DRUG: Omega 3/Nigella Sativa Oil/Indian Costus|DRUG: Omega 3/Nigella Sativa Oil/Quinine pills|DRUG: Omega 3/Nigella Sativa Oil/Anise seed capsule|DRUG: Omega 3/Nigella Sativa Oil/Deglycyrrhizinated Licorice|DRUG: Active Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Mitigating the Impact of Stigma and Shame Among MSM Living With HIV and Substance Use Disorders
Status: NOT_YET_RECRUITING
Conditions: Hiv|Substance Use Disorders
Interventions: BEHAVIORAL: Matter Intervention|BEHAVIORAL: Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Diabetes Action Team in Patients Post Infrainguinal Bypass Surgery With and Without Diabetes
Status: TERMINATED
Conditions: Type 2 Diabetes|Peripheral Vascular Disease
Interventions: BEHAVIORAL: Subjects with diabetes who plan to undergo elective infrainguinal bypass surgery will receive standard diabetes care by their admitting physician|BEHAVIORAL: Subjects with diabetes who plan to undergo elective infrainguinal bypass surgery will receive diabetes care under the direction of the Diabetes Action Team|BEHAVIORAL: Subjects without diabetes will have their blood glucose levels monitored while in the hospital
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety of and Immune Response to an Adenoviral HIV-1 Vaccine in Healthy Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: Ad26.ENVA.01 HIV-1 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Advanced Solid Tumors With TSA-CTL(Tumor Specific Antigen-Induced Cytotoxic T Lymphocytes)
Status: COMPLETED
Conditions: Solid Cancer
Interventions: BIOLOGICAL: TSA-CTL|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of LOP628 in Adult Patients With cKit-positive Solid Tumors and Acute Myeloid Leukemia
Status: TERMINATED
Conditions: cKIT-positive Solid Tumors|AML
Interventions: DRUG: LOP628
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maternal Therapy With TAF Versus TDF to Prevent Vertical Transmission of Hepatitis B
Status: UNKNOWN
Conditions: Hepatitis B, Chronic|Pregnancy Related
Interventions: DRUG: Tenofovir Alafenamide 25 MG for arm (A)|DRUG: Tenofovir Disoproxil Fumarate 300mg for arm (B)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Use of Bone-borne Guides in Orthognathic Surgery Cases
Status: COMPLETED
Conditions: Dentofacial Deformities
Interventions: DEVICE: Bone-borne CAD/CAM splint|DEVICE: 3D interocclusal conventional splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Oxylipin Response as a New PrEdictive Biomarker of Patient Responsiveness to Biotherapy in Rheumatoid Arthritis (OPERA)
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: OTHER: Blood test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Safety and Tolerability of Egalet-002 in Patients With Moderate-to-Severe Chronic Noncancer Pain
Status: COMPLETED
Conditions: Moderate-to-severe Chronic Noncancer Pain
Interventions: DRUG: Oxycodone extended-release
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double Blind Randomized Trial of Saline vs Pentaspan for Resuscitation After Cardiac Surgery
Status: COMPLETED
Conditions: Cardiac Surgery
Interventions: OTHER: Pentaspan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Phase Clinical Trial About Therapeutic Biological Product Mix for Treating CEA Positive Rectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Rectal Cancer
Interventions: BIOLOGICAL: CEA protein antigen plus BCG Vaccine Mix for percutaneous use
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Telerehabilitation in Hemato-oncological Survivors
Status: RECRUITING
Conditions: Hematologic Malignancy|Lymphoma
Interventions: DEVICE: Home-based training|DEVICE: Center-based training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy, Tolerability, and Cognitive Effects of Deep Transcranial Magnetic Stimulation for Bipolar Depression
Status: RECRUITING
Conditions: Bipolar Depression
Interventions: DEVICE: deep Transcranial Magnetic Stimulation (dTMS) -active|DEVICE: deep Transcranial Magnetic Stimulation (dTMS) -sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Lanadelumab in Teenagers and Adults to Prevent Acute Attacks of Non-histaminergic Angioedema With Normal C1-Inhibitor (C1-INH)
Status: COMPLETED
Conditions: Angioedema
Interventions: OTHER: Placebo|DRUG: Lanadelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ketorolac Premedication for Anesthetic Efficiency of IANB & Postendodontic Pain in Teeth With Irreversible Pulpitis
Status: UNKNOWN
Conditions: Irreversible Pulpitis
Interventions: DRUG: Ketorolac Tromethamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Apatinib in the Treatment of Recurrent Atypical/Malignant Meningioma in Adults
Status: RECRUITING
Conditions: Recurrent Atypical/Malignant Meningioma
Interventions: DRUG: Apatinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Mogamulizumab + Nivolumab in Subjects w/Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor|Cancer|Carcinoma|Hepatocellular Carcinoma|HCC
Interventions: BIOLOGICAL: Mogamulizumab + Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Morbid Obesity and Bariatric Surgery on Brain Inflammation, Insulin Resistance and Central Reward System
Status: UNKNOWN
Conditions: Obesity, Morbid|Insulin Resistance
Interventions: PROCEDURE: Bariatric surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Skin Sympathetic Nerve Activity According to Different Anesthetics
Status: WITHDRAWN
Conditions: SKNA According to Different Anesthetics
Interventions: DRUG: Propofol continuous infusion|DRUG: Remifentanil|DRUG: Sevoflurane|DRUG: Desflurane|DRUG: Propofol bolus injection|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: D-Dimer Guided Oral Anticoagulant Treatment (OAT)
Status: UNKNOWN
Conditions: Deep Venous Thrombosis
Interventions: DRUG: Phenprocoumon|DRUG: Warfarin-Natrium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Can Urinary Partial Oxygen Pressure be an Indicator of Acute Kidney Injury in Patients With Sepsis?
Status: NOT_YET_RECRUITING
Conditions: Acute Kidney Injury|Sepsis
Interventions: DIAGNOSTIC_TEST: arterial blood gases
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Urinary Incontinence Amongst Women With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Urinary Incontinence
Interventions: PROCEDURE: Pelvic floor muscle training|PROCEDURE: Cough-suppression therapy|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Hyperbaric Oxygen for ARDS in Patients With COVID-19
Status: TERMINATED
Conditions: SARS (Severe Acute Respiratory Syndrome)|Cytokine Storm|ARDS, Human|COVID-19|Sars-CoV2|Acute Respiratory Failure
Interventions: DRUG: Hyperbaric oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Quadrivalent Influenza Virus Split Vaccine in Population Aged 3-8 Years
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: Quadrivalent Influenza Virus Split Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Internet Intervention for the Prevention of Depression - Approaches to Improving Mood
Status: WITHDRAWN
Conditions: Individuals at Risk for Depression
Interventions: BEHAVIORAL: AIM Web based intervention + surveillance|BEHAVIORAL: AIM web based intervention|BEHAVIORAL: Educational website
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Protein Product in Volunteers With Sarcopenia
Status: NOT_YET_RECRUITING
Conditions: Sarcopenia
Interventions: DIETARY_SUPPLEMENT: whey protein isolate|DIETARY_SUPPLEMENT: isolated soy protein|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Rebound Pain After Operations for Distal Radius Fractures With a Volar Plate in Brachial Plexus Block
Status: COMPLETED
Conditions: Brachial Plexus Block|Pain, Postoperative
Interventions: DRUG: Dexamethasone|DRUG: NaCl (Control)|DRUG: Paracetamol|DRUG: EtoriCoxib|DRUG: Oxycodone|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antioxidant Supplementation in Pregnant Women
Status: COMPLETED
Conditions: Pregnant Women|Preeclampsia
Interventions: DIETARY_SUPPLEMENT: micronutrient antioxidant|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: the Safety and Efficacy Evaluation of HGI-002 Injection in Patients With Transfusion-Dependent α-Thalassemia
Status: RECRUITING
Conditions: α-thalassemia
Interventions: BIOLOGICAL: α-globin restored autologous hematopoietic stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DIetary Supplements, Executive funcTions and Vitamin D (DIET-D)
Status: UNKNOWN
Conditions: Mild Cognitive Impairment
Interventions: DRUG: Lecitone®Se-Vitamin D3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Negative Pressure Wound Therapy vs. Sterile Dressing for Patients Undergoing Thoracolumbar Spine Surgery
Status: UNKNOWN
Conditions: Metastatic Disease|Spinal Cord Injury|Spinal Degeneration|Spinal Deformity
Interventions: DEVICE: Vacuum Assisted Closure|OTHER: Sterile dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Snow Physical Properties and Human Ventilatory Response
Status: COMPLETED
Conditions: Hypoxic Respiratory Failure|Hypercapnic Respiratory Failure|Avalanche Burial|Snow Physical Properties
Interventions: OTHER: Breathing in snow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Safety and Tolerability Study of RJX Drug Product in Healthy Participants
Status: COMPLETED
Conditions: Critical Limb Ischemia
Interventions: DRUG: RJX|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial of Compassionate Use of hp802-247 to Treat Venous Leg Ulcers in Subjects Who Have Failed Multiple Other Healing Technologies
Status: UNKNOWN
Conditions: Venous Leg Ulcer
Interventions: BIOLOGICAL: Weekly wound spray with components 1 and 2 of the compound HP802-247
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Banhasasim-tang on Functional Dyspepsia
Status: COMPLETED
Conditions: Functional Dyspepsia
Interventions: DIETARY_SUPPLEMENT: Banhasasim-tang|DIETARY_SUPPLEMENT: Corn-starch granules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Suppression of Toll Like Receptors by Insulin
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: DRUG: insulin infusion|DRUG: Dextrose infusion|DRUG: Saline Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Dietary Antioxidants on Cardiovascular Risk Factors
Status: COMPLETED
Conditions: Obesity|Hyperlipidemia|Hypertension
Interventions: BEHAVIORAL: Antioxidant diet|DIETARY_SUPPLEMENT: Antioxidant supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: High and Low Dose Carbidopa Treatment of Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: carbidopa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy and Safety of Sarilumab in Patients With GCA
Status: TERMINATED
Conditions: Giant Cell Arteritis
Interventions: DRUG: Sarilumab SAR153191|DRUG: Sarilumab matching placebo|DRUG: Prednisone|DRUG: Prednisone matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Incidence of Diabetes and Cardiovascular Disease in Mexican Americans
Status: COMPLETED
Conditions: Cardiovascular Diseases|Heart Diseases|Myocardial Infarction|Angina Pectoris|Death, Sudden, Cardiac|Cerebrovascular Disorders|Peripheral Vascular Diseases|Coronary Disease|Diabetes Mellitus, Non-insulin Dependent|Diabetes Mellitus
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Tolerability and PK of a Single iv Infusion of 10, 40, and 80 µg/kg XG-102 Administered to Healthy Volunteers
Status: COMPLETED
Conditions: Inflammation
Interventions: DRUG: XG-102
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CRP Apheresis in STEMI
Status: RECRUITING
Conditions: ST Elevation Myocardial Infarction|C-Reactive Protein|Apheresis|Myocardial Injury
Interventions: DEVICE: Selective CRP apheresis using the PentraSorb®-CRP system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of AL-53817 Nasal Spray Solution
Status: COMPLETED
Conditions: Nasal Allergies|Allergies
Interventions: DRUG: AL-53817 nasal spray solution|OTHER: Vehicle nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Alternate Formula Feedings in Formula Intolerant Infants
Status: COMPLETED
Conditions: Gastrointestinal Tolerance
Interventions: OTHER: Infant Formula 1|OTHER: Infant Formula 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: rATG Versus rATG Combined With Intravenous Immunoglobulin (IVIG) Induction Immunosuppression in HLA Incompatible Transplantation (INHIBIT)
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: Privigen|DRUG: Thymoglobulin|OTHER: Plasma Exchange
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Computational Simulation to Plan for Percutaneous Left Atrial Appendage Closure
Status: UNKNOWN
Conditions: Atrial Fibrillation|Stroke Prevention
Interventions: OTHER: Additional support for preoperative planning of LAA closure procedures|PROCEDURE: Left atrial appendage closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vaginal CO2 Laser and the Genitourinary Syndrome of Menopause
Status: UNKNOWN
Conditions: Vaginal Atrophy
Interventions: DEVICE: Microablative Fractional CO2 laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Raloxifene in Treatment of Schizophrenia and Schizoaffective Disorder
Status: UNKNOWN
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: raloxifene|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis
Status: RECRUITING
Conditions: Lumbar Spinal Stenosis|Cardiac Amyloidosis|ATTR Amyloidosis Wild Type|ATTR Gene Mutation|ATTRV122I Amyloidosis|Cardiomyopathy, Hypertrophic
Interventions: DIAGNOSTIC_TEST: Tc99-PYP or Tc99-HDMP Scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Allogeneic Natural Killer (NK) Cells in Patients With Advanced Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide|RADIATION: Total body irradiation|OTHER: Natural killer cell infusion|BIOLOGICAL: Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dapagliflozin vs Sitagliptin on Liver Fat Accumulation and Body Composition in Patients With Diabetes Mellitus and Liver Transplantation
Status: RECRUITING
Conditions: Diabetes Mellitus|Liver Transplant; Complications
Interventions: DRUG: Dapagliflozin 10Mg Tab|DRUG: Sitagliptin 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib
Status: RECRUITING
Conditions: GIST
Interventions: DRUG: Ripretinib|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel Plus Radiation With Erlotinib to Treat Esophageal Squamous Carcinoma
Status: UNKNOWN
Conditions: Esophageal Squamous Carcinoma
Interventions: DRUG: Paclitaxel|DRUG: Erlotinib|RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propofol vs Sevo for Paediatric Tumor Surgery
Status: RECRUITING
Conditions: Solid Tumor|Carcinoma|Malignancy|Cancer
Interventions: DRUG: propofol|DRUG: sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of N-Acetyl Cysteine in Children With Autism
Status: COMPLETED
Conditions: Autistic Disorder
Interventions: DRUG: N-Acetyl Cysteine|OTHER: Placebo - sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT