pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Open-Label Prospective Study Comparing Long-Term Outcome With or Without HFNC in Patients With Stable Hypercapnic COPD
Status: UNKNOWN
Conditions: COPD
Interventions: DEVICE: HFNC Airvo|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Pharmacokinetics, Safety and Effects of NutriterraTM in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: NutriterraTM|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Definitive Estrogen Patch Study (ADEPT)
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder(Not in Manic Phase)
Interventions: DRUG: Estradiol|DRUG: Estradiol|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BI 6727 (Volasertib) Randomised Trial in Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Neoplasms
Interventions: DRUG: Paclitaxel|DRUG: Gemcitabine|DRUG: Topotecan|DRUG: Pegylated liposomal doxorubicin (PLD)|DRUG: BI 6727
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arterial Hypertension Related to PARP Inhibitors (ArteRIB)
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: olaparib, rucaparib, niraparib, talazoparib, veliparib, pamiparib, fluzoparib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Multi-center Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel, When Used to Treat Actinic Keratoses on the Head (Face or Scalp)
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: PEP005 Gel|DRUG: Vehicle gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Timing of Transcranial Direct Current Stimulation (tDCS) Combined With Speech and Language Therapy (SLT)
Status: UNKNOWN
Conditions: Aphasia
Interventions: DEVICE: Offline tDCS-before therapy|DEVICE: Sham tDCS|DEVICE: Offline tDCS-after therapy|DEVICE: Online tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Naturalistic Substitution of Concerta in Adult Subject With ADHD Receiving Immediate Release Methylphenidate
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: methylphenidate hydrochloride|DRUG: OROS methylphenidate hydrochloride (CONCERTA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)
Status: COMPLETED
Conditions: Acute Renal Failure|Chronic Kidney Failure|Endothelial Dysfunction|Hemolytic-uremic Syndrome (HUS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ONYX-015 With Cisplatin and Fluorouracil in Treating Patients With Advanced Head and Neck Cancer
Status: WITHDRAWN
Conditions: Lip and Oral Cavity Cancer|Head and Neck Cancer|Oropharyngeal Cancer
Interventions: DRUG: cisplatin|DRUG: fluorouracil|DRUG: ONYX-015
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Impact of Systematic Early Tuberculosis Detection Using Xpert MTB/RIF Ultra in Children With Severe Pneumonia in High Tuberculosis Burden Countries (TB-Speed Pneumonia)
Status: COMPLETED
Conditions: Tuberculosis|Severe Pneumonia|Covid19
Interventions: DIAGNOSTIC_TEST: Xpert MTB/RIF Ultra (Ultra)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tumors Harboring Activating FGFR1-3 Alterations
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma|Adult-type Diffuse Gliomas
Interventions: DRUG: Pemigatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Dissection of Lymph Node Posterior to Right Recurrent Laryngeal Nerve for Papillary Thyroid Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Lymph Node Metastases
Interventions: PROCEDURE: lymph node dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
Status: RECRUITING
Conditions: Cognitive Impairment, Mild|Dementia|Cardiovascular Diseases
Interventions: DRUG: Atorvastatin 40 Mg Oral Tablet|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Ischemic and Bleeding Outcomes After Angiolite Stent Implantation and an Abbreviated Dual Antiplatelet Therapy
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: Angiolite: Sirolimus-eluting stent|DEVICE: Xience: Sirolimus-eluting stent|DRUG: 1-month DAPT|DRUG: 12-month DAPT (Standard of care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab TX-naive Distant Mets Melanoma and Use of (C11-AMT) PET at Baseline as Imaging Biomarker
Status: COMPLETED
Conditions: Melanoma
Interventions: DIAGNOSTIC_TEST: FDG PET/CT scan|DIAGNOSTIC_TEST: C11-AMT PET scan|DRUG: Pembrolizumab|DIAGNOSTIC_TEST: CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of the Efficacy and Safety of Dupilumab Versus Placebo in Patients With Netherton Syndrome
Status: RECRUITING
Conditions: Netherton Syndrome
Interventions: DRUG: Dupilumab Prefilled Syringe|OTHER: Placebo Prefilled Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of Sequencing From antiCD-20 Therapies to Ozanimod
Status: NOT_YET_RECRUITING
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: Ozanimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Action of Acetaminophen
Status: COMPLETED
Conditions: Myocardial Infarction|Arthritis
Interventions: DRUG: Aspirin First|DRUG: Aspirin Last|DRUG: Acetaminophen 1000 mg/d|DRUG: Acetaminophen 4000 mg/d|DRUG: Ibuprofen 800 mg/d
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proactive TDM Versus Standard Use of Biologics in Psoriasis
Status: NOT_YET_RECRUITING
Conditions: Psoriasis Vulgaris
Interventions: DRUG: Proactive TDM-based dosing of secukinumab|DRUG: Proactive TDM-based dosing of ixekizumab|DRUG: Proactive TDM-based dosing of guselkumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydros Joint Therapy and Hydros-TA Joint Therapy for Pain Associated With Knee Osteoarthritis (OA)
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DEVICE: Hydros Joint Therapy|DEVICE: Hydros-TA Joint Therapy|DEVICE: Synvisc-One
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of a Chlorhexidine Antimicrobial Dressing
Status: COMPLETED
Conditions: Catheterization
Interventions: DRUG: Chlorhexidine gluconate|DRUG: Transparent Adhesive Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Simultaneous Cochlear Implantation During Translabyrinthine Resection of Vestibular Schwannoma
Status: COMPLETED
Conditions: Vestibular Schwannoma|Cochlear Implantation
Interventions: DEVICE: Cochlear implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Corticosteroids to Treat Pancreatitis
Status: RECRUITING
Conditions: Pancreatitis|Pancreatitis, Acute|Corticosteroid|Hydrocortisone
Interventions: DRUG: Hydrocortisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The (Cost)Effectiveness of Increasing Protein Intake on Physical Funtioning in Older Adults
Status: COMPLETED
Conditions: Protein-Energy Malnutrition|Physical Disability
Interventions: OTHER: Dietary advice|OTHER: Dietary advice and advice on timing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A First Human Dose Trial Investigating Safety, Tolerability and Pharmacokinetics for Single Doses and Multiple Doses of NNC0165-1562 in Overweight to Obese But Otherwise Healthy Subjects
Status: COMPLETED
Conditions: Metabolism and Nutrition Disorder|Obesity
Interventions: DRUG: NNC0165-1562|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation: The ASANTE Trial
Status: COMPLETED
Conditions: Trachoma
Interventions: OTHER: Surveillance and treatment with azithromycin of newcomer and traveler families|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pre-sacral Nerve Block on Immediate Post-operative Pain Following Laparoscopic Hysterectomy.
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: Bupivacaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Add-On Therapy to Risperidonein Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Dextromethorphan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Enteral Products for Tube Fed Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: standard enteral feeding product|OTHER: Diabetes specific feeding product
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketamine for Treatment Resistant Late-Life Depression
Status: COMPLETED
Conditions: Treatment Resistant Depressive Disorder
Interventions: DRUG: Ketamine|DRUG: Ketamine|DRUG: Ketamine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of GMRx2 Compared to Placebo for the Treatment of Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan 10 mg/amlodipine 1.25 mg/indapamide 0.625 mg|DRUG: Telmisartan 20 mg/amlodipine 2.5 mg/indapamide 1.25 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Azathioprine in MOGAD
Status: NOT_YET_RECRUITING
Conditions: Central Nervous System Inflammation|MOG-IgG Associated Disease
Interventions: DRUG: Azathioprine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sublingual Misoprostol With or Without Intravenous Tranexamic Acid During Hemorrhagic Cesarean Section
Status: UNKNOWN
Conditions: Cesarean Section Complications
Interventions: DRUG: Misoprostol|DRUG: Tranexamic Acid|DRUG: placebo to tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Poziotinib in EGFR Exon 20 Mutant Advanced NSCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: EGFR Exon 20 Mutation|ERBB2 Gene Mutation|Recurrent Lung Non-Small Cell Carcinoma|Stage IV Non-Small Cell Lung Cancer AJCC v7
Interventions: DRUG: Poziotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Dapagliflozin 10 mg Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Dapagliflozin 10 mg tablets|DRUG: Farxiga® 10 mg tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study of Cognitive Outcomes for Subjects Who Have Had Prior PET Amyloid Imaging With Florbetapir F 18 (18F-AV-45)
Status: COMPLETED
Conditions: Alzheimer's Disease|Mild Cognitive Impairment
Interventions: DRUG: florbetapir F 18
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Modulation of Brain Oscillations Underlying Working Memory
Status: NOT_YET_RECRUITING
Conditions: Working Memory
Interventions: DEVICE: Active tACS|DEVICE: Placebo tACS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Oral Belumosudil in Black or African American, American Indian or Alaska Native, and Native Hawaiian or Other Pacific Islander Male and Female Participants Aged 12 Years and Above With Chronic Graft Versus Host Disease (cGVHD) After At Least 2 Prior Lines of Systemic Therapy
Status: RECRUITING
Conditions: Chronic Graft Versus Host Disease
Interventions: DRUG: Belumosudil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictors of Ovarian Response During Clomiphene Citrate Ovulation Induction in Patients With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Anovulation
Interventions: DRUG: clomiphen citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Robotic-assisted Locomotor Training on Mobility and Cardiopulmonary Function in Patients Suffering From Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: DEVICE: Robotic-assisted body weight supported treadmill training (Lokomat V6, Hocoma AG, Switzerland)|DEVICE: Passive lower limbs mobilization training (Motomed Vivo 2, RECK, Germany)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vinorelbine/Carboplatin Versus Gemcitabine/Carboplatin in Metastatic Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Vinorelbine|DRUG: Gemcitabine|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Pyridostigmine for Constipation in Diabetics
Status: COMPLETED
Conditions: Constipation|Diabetes Mellitus|Colonic Transit|Gastric Emptying
Interventions: DRUG: Pyridostigmine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Digital Non-interventional Atrial Fibrillation (AF) Screening Study With Commercial Pulse Detection Systems
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: 12-point-ECG|DEVICE: Polar V800|DEVICE: 360° eMotion FAROS SET + Belt|DEVICE: Adidas Micoach smart run|DEVICE: TomTom Runner Cardio HRM
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General Anesthesia
Status: UNKNOWN
Conditions: Coughing Response|Thyroid Surgery|General Anesthesia
Interventions: DRUG: Dexmeditomidine|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pain Neuroscience Education for Patients Who Experience Chronic Pain With Concurrent Opioid Dependence
Status: COMPLETED
Conditions: Chronic Pain|Opioid Dependence
Interventions: OTHER: Pain Neuroscience Education|OTHER: General Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dabrafenib and Trametinib in Patients With Non-small Cell Lung Cancer Harboring V600E BRAF Mutation
Status: UNKNOWN
Conditions: Cancer|Lung Cancer Metastatic|BRAF V600E
Interventions: DRUG: daborafenib plus trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Role of PCSK9 and FXR in the Physiopathology of the Joint Dyslipidemia Associated to the Human Immunoresistance
Status: COMPLETED
Conditions: Obesity
Interventions: PROCEDURE: biopsy of muscle, of liver, and of adipose tissue|PROCEDURE: clamp euglycemic - hyperglycemic|BEHAVIORAL: diet|OTHER: biopsies for biological and genetic analyses
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Balance Training With Gaze Stabilization Exercises in Elderly Patients With Chronic Dizziness
Status: COMPLETED
Conditions: Chronic Dizziness
Interventions: OTHER: Gaze Stabilization Exercises|OTHER: Balance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Dreamed Advisor Pro for Automated Insulin Pump Setting Adjustments in Children and Adolescents With Type 1 Diabetes- The Advice4U Pro Study
Status: COMPLETED
Conditions: Type1 Diabetes Mellitus
Interventions: DEVICE: DreaMed Advisor Pro|OTHER: Medical guided recommendation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Bupivacaine With Standard Bupivacaine Versus Dexmedetomidine With Standard Bupivacaine
Status: RECRUITING
Conditions: Acute Pain
Interventions: DRUG: Bupivacaine Liposome 13.3 Milligrams/Milliliter [Exparel]|DRUG: Dexmedetomidine 0.5milligram (50micrograms)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation for Facial Pain
Status: COMPLETED
Conditions: Trigeminal Nerve Injuries|Post-herpetic Neuralgia|Facial Pain|Nervus Intermedius Neuralgia
Interventions: DEVICE: transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Norepinephrine Weaning in Septic Patients
Status: COMPLETED
Conditions: Septic Shock
Interventions: DEVICE: norepinephrine infused at the clinician's discretion|DEVICE: norepinephrine infused under computerized fuzzy logic control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PANLAR's Latin American Registry of Rheumatic Patients Treated With Jak Inhibitors
Status: UNKNOWN
Conditions: Arthritis, Rheumatoid|Arthritis, Psoriatic|Spondyloarthritis
Interventions: DRUG: DMARDs|DRUG: biologic DMARDs|DRUG: JAK Inhibitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomized Trial of Cryotherapy Duration Prior to High Dose Melphalan in Myeloma Patients
Status: COMPLETED
Conditions: Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma
Interventions: PROCEDURE: cryotherapy|OTHER: questionnaire administration|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post Market Clinical Follow-up of CODMAN CERTAS Programmable Valve
Status: RECRUITING
Conditions: Hydrocephalus|Hydrocephalus in Children|NPH (Normal Pressure Hydrocephalus)|IIH - Idiopathic Intracranial Hypertension|Brain Tumor|Post-Traumatic Hydrocephalus|Hemorrhagic Stroke
Interventions: DEVICE: CODMAN CERTAS Plus Programmable Valve
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Urelumab in Subjects With Advanced and/or Metastatic Malignant Tumors
Status: COMPLETED
Conditions: Malignant Tumors
Interventions: DRUG: Urelumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supplemental Perioperative Intravenous Crystalloids for Postoperative Nausea and Vomiting in Children Undergoing Oncological Surgery
Status: COMPLETED
Conditions: Nausea and Vomiting, Postoperative
Interventions: DRUG: Ringer's Lactate|DRUG: Ringer's Lactate|DRUG: Ringer's Lactate|DRUG: normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Spectroscopic Imaging at 4T: A Drug Challenge Study
Status: TERMINATED
Conditions: AOD Effects and Consequences
Interventions: DRUG: Alprazolam|DRUG: Dextroamphetamine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sentinel Node Mapping in Women With Endometrial and Cervical Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Uterine Cervical Neoplasms|Uterine Neoplasms
Interventions: PROCEDURE: SLN mapping and removal of PET-positive lymph nodes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Remimazolam on Prognosis After Bladder Cancer Surgery
Status: RECRUITING
Conditions: Benzodiazepines|Bladder Cancer|Delirium|Surgery|Cancer Recurrence
Interventions: DRUG: Remimazolam|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combining Acceptance and Commitment Therapy With Exposure and Response Prevention to Enhance Treatment Engagement
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: BEHAVIORAL: ACT plus ERP|BEHAVIORAL: ERP alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RECOVER-AUTONOMIC: Platform Protocol, Appendix B (Ivabradine)
Status: RECRUITING
Conditions: Long COVID|Long Covid19|Long Covid-19
Interventions: DRUG: Ivabradine|DRUG: Ivabradine Placebo|BEHAVIORAL: Coordinated Care|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Measuring Distress in Prosthetic Joint Infection Using a Standardized Metric: CRUTCH Pathway Pilot.
Status: COMPLETED
Conditions: Prosthetic Joint Infection
Interventions: BEHAVIORAL: CRUTCH Pathway
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Protocol for Feeding Intolerance in Preterm Infants
Status: RECRUITING
Conditions: Feeding Intolerance|Preterm Infants
Interventions: DIETARY_SUPPLEMENT: formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Variability in Response to Non-steroidal Anti-inflammatory Drugs
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: Celecoxib|DRUG: Naproxen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effect of Olvanil Supplementation on Clinical, Biochemical and Anthropometric Parameters in Obese Adults
Status: RECRUITING
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Olvanil|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a Vaccine for Cutaneous Leishmaniasis Using Recombinant Human Interleukin-12 and Aluminum Hydroxide Gel as Adjuvants
Status: COMPLETED
Conditions: Cutaneous Leishmaniasis
Interventions: BIOLOGICAL: Combination of autoclaved leishmania antigen with recombinant human interleukin-12 (rhIL-12) and aluminum hydroxide gel as adjuvants
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Prospective Trial of Digital Breast Tomosynthesis (DBT) in Breast Cancer Screening.
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DIAGNOSTIC_TEST: digital breast tomosynthesis|DIAGNOSTIC_TEST: standard two dimension digital mammogram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Testing the Use of BRAF-Targeted Therapy After Surgery and Usual Chemotherapy for BRAF-Mutated Colon Cancer
Status: RECRUITING
Conditions: Colon Adenocarcinoma|Microsatellite Stable Colon Carcinoma|Stage IIB Colon Cancer AJCC v8|Stage IIC Colon Cancer AJCC v8|Stage III Colon Cancer AJCC v8
Interventions: DRUG: Encorafenib|BIOLOGICAL: Cetuximab|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|OTHER: Patient Observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combine TACE and Autologous Tcm Immunotherapy Versus TACE Alone for HCC With MVI After Radical Resection
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Malignant Neoplasm
Interventions: COMBINATION_PRODUCT: TACE plus autologous Tcm immunotherapy|PROCEDURE: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Neurosensory Account
Status: RECRUITING
Conditions: Post Traumatic Stress Disorder
Interventions: DEVICE: alpha-frequency tACS|DEVICE: Random noise stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: DS-5565 Phase III Study for Diabetic Peripheral Neuropathic Pain
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathic Pain
Interventions: DRUG: DS-5565|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Water Intake Associated With Aerobic Exercise in Coronary
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: OTHER: Treadmill aerobic exercise in supine position|OTHER: Treadmill aerobic exercise and water intake in supine position|OTHER: Treadmill aerobic exercise in orthostatic position|OTHER: Treadmill aerobic exercise and water intake in orthostatic position
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: TORPEDO Study: A Study on Rapid Effect of Tocilizumab in Patients With Rheumatoid Arthritis With an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs) or Anti-TNF
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: tocilizumab [RoActemra/Actemra]|DRUG: placebo|DRUG: tocilizumab [RoActemra/Actemra]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ofatumumab in Children With Drug Resistant Idiopathic Nephrotic Syndrome
Status: TERMINATED
Conditions: Nephrotic Syndrome
Interventions: DRUG: Ofatumumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Electrical Stimulation During Immobilization Due to Ankle Fractures
Status: TERMINATED
Conditions: Immobilization|Muscle Disuse Atrophy
Interventions: DEVICE: Neuromuscular Electrical Stimulation (NMES)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Study Evaluating the Safety and Efficacy of BinD19 Treatment in Childhood R/R ALL and Lymphoma Subjects
Status: UNKNOWN
Conditions: Relapsed B-cell Acute Lymphoblastic Leukemia, Childhood|Refractory B-cell Acute Lymphoblastic Leukemia, Childhood|Relapsed/Refractory B-cell Lymphoma, Childhood
Interventions: BIOLOGICAL: BinD19
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficiency of Endovascular Treatment of Acute or Subacute Thromboembolic Occlusions of Lower Extremity.
Status: RECRUITING
Conditions: Thromboembolic Disease|Lower Extremity Problem|Endovascular Treatment|Safety Issues|Efficacy, Self
Interventions: PROCEDURE: endovascular treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Targeting Platelets in Chronic HIV Infection
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: Clopidogrel|DRUG: Aspirin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Birmingham Hip Resurfacing (BHR) Study: Implantation of a Hip Resurfacing Endoprosthesis
Status: UNKNOWN
Conditions: Arthritis
Interventions: DEVICE: Birmingham Hip Resurfacing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ABC/Trident® Ceramic Post Approval Study
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Hip
Interventions: DEVICE: Trident® Ceramic Insert/Trident® AD HA Acetabular Shell|DEVICE: Alumina Insert/PSL® Microstructured Acetabular Shell or Secur-Fit® HA PSL® Acetabular Shell|DEVICE: OmniFit® Series II Insert/OmniFit® PSL® Microstructured Acetabular Shell
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing a Nutritional Supplement to Increase Collagen Synthesis in People
Status: RECRUITING
Conditions: Dietary Supplements|Connective Tissue|Exercise
Interventions: DIETARY_SUPPLEMENT: Natural Product Supplement|DIETARY_SUPPLEMENT: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CardiAMP™ Cell Therapy for Heart Failure Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure, Systolic
Interventions: BIOLOGICAL: Autologous cell therapy|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultramicronized Palmitoylethanolamide (PEA) Treatment in Hospitalized Participants With COVID-19
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: FSD201|DRUG: Placebo|OTHER: Standard of Care for Covid-19
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Surgery or Standard Surgery in Treating Patients With Endometrial Cancer or Cancer of the Uterus
Status: COMPLETED
Conditions: Endometrial Adenocarcinoma|Stage I Uterine Corpus Cancer|Stage I Uterine Sarcoma|Stage II Uterine Corpus Cancer|Stage II Uterine Sarcoma
Interventions: PROCEDURE: Laparoscopic Surgery|OTHER: Quality-of-Life Assessment|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of Cell Population in Solution-Induced Corneal Staining (SICS) and Symptomatic Versus Asymptomatic Lens Wearers
Status: COMPLETED
Conditions: Refractive Error|Dry Eye
Interventions: DEVICE: Balafilcon A contact lens|DEVICE: Habitual contact lenses|DEVICE: Renu multi-purpose solution|DEVICE: ClearCare|DEVICE: Habitual lens care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Diabetes Clinical Decision Support
Status: RECRUITING
Conditions: Hyperglycemia|Hyperglycemia Stress|Diabetes|PreDiabetes|Hypoglycemia
Interventions: DEVICE: Active Electronic Medical Record Inpatient Diabetes Clinical Decision Support
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Correlation Between Vitamin D Status and Bone Mineral Density in Patients With Hemophilia
Status: COMPLETED
Conditions: Hemophilia A|Hemophilia B|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D and calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Efficacy of Azithromycin-associated Hydroxychloroquine Therapy Given in General Practice in Early-stage Disease in COVID-19 Patients
Status: WITHDRAWN
Conditions: Covid-19
Interventions: DRUG: Hydroxychloroquine and Azithromycin|DIETARY_SUPPLEMENT: Azinc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRI 3D UTE Hyper-Cones & ZTE for PET/MR Lung Attenuation Correction & for Lung Diagnostic Imaging
Status: TERMINATED
Conditions: Lung Diseases
Interventions: DIAGNOSTIC_TEST: PET/MR image acquisition
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Behavioral Chronotype: Impact on Sleep and Metabolism
Status: ACTIVE_NOT_RECRUITING
Conditions: Type2 Diabetes Mellitus|Cardiovascular Diseases
Interventions: BEHAVIORAL: Early Total Caloric Intake|BEHAVIORAL: Late Total Caloric Intake|BEHAVIORAL: Extended Overnight Fast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effects of Oxiris on Systemic Inflammation and Endothelial dysFunction
Status: UNKNOWN
Conditions: Acute Kidney Injury Due to Circulatory Failure (Disorder)
Interventions: DEVICE: oXiris membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Daratumumab for Treatment of Proliferative Glomerulonephritis With Monoclonal Immune Deposits
Status: RECRUITING
Conditions: Proliferative Glomerulonephritis With Monoclonal IgG Deposits
Interventions: DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A COVID-19 Study to Evaluate Safety and PK of COVID-HIG Administered Through IM, SC, or IV Routes as a Single Dose Regimen to SARS-CoV-2 Uninfected Adults
Status: COMPLETED
Conditions: SARS-CoV-2 Infection
Interventions: BIOLOGICAL: COVID-HIG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of "in UTERO" Exposure to Glucocorticoids
Status: UNKNOWN
Conditions: 21-hydroxylase; Defect
Interventions: PROCEDURE: Euglycemic hyperinsulinemic clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: MRI Scans in Evaluating the Effects of Radiation Therapy and Chemotherapy in Patients With Newly Diagnosed Glioblastoma Multiforme or Anaplastic Glioma
Status: TERMINATED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: temozolomide|OTHER: Imaging biomarker analysis|RADIATION: Photon Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers (Protocol 3)
Status: COMPLETED
Conditions: Vascular Disease|Heart Disease
Interventions: DRUG: NO clamp|DRUG: Saline|DRUG: Fluconazole|DRUG: Aspirin|DRUG: Combined
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Economic Evaluation of Femtosecond Laser Assisted Cataract Surgery
Status: COMPLETED
Conditions: Cataract
Interventions: PROCEDURE: Cataract surgery with Phacoemulsification|DEVICE: Femtosecond laser-assisted cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: MK2206 and Erlotinib Hydrochloride in Treating Patients With Advanced Non-Small Cell Lung Cancer Who Have Progressed After Previous Response to Erlotinib Hydrochloride Therapy
Status: COMPLETED
Conditions: Adenosquamous Lung Carcinoma|Bronchioloalveolar Carcinoma|Large Cell Lung Carcinoma|Lung Adenocarcinoma|Recurrent Non-Small Cell Lung Carcinoma|Squamous Cell Lung Carcinoma
Interventions: DRUG: Akt Inhibitor MK2206|DRUG: Erlotinib Hydrochloride|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of 188-0551 Spray Versus Reference Listed Drug (RLD) in Adult Subjects With Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: 188-0551 Spray|DRUG: RLD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Six Months Dual Antiplatelet Therapy After Drug-Eluting Stenting
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: Clopidogrel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Nurse-led Program for the Prevention of Complications of Long-term Corticosteroid Therapy
Status: RECRUITING
Conditions: Long Term Corticosteroid Therapy
Interventions: OTHER: nurse-led prevention program|OTHER: Current care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Effects of Canagliflozin (JNJ-28431754) on the Pharmacokinetics and Safety of Digoxin in Healthy Volunteers.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Digoxin 0.5 mg|DRUG: Digoxin 0.25 mg|DRUG: Canagliflozin (JNJ-28431754)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study to Explore the Safety and Pharmacokinetics of DAPAglifozin in Adolescents and Adults With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation of a Trimodal Prehabilitation Program as a Preoperative Optimization Strategy in Cardiac Surgery and Heart Transplant
Status: COMPLETED
Conditions: Coronary Artery Disease|Valvular Heart Disease
Interventions: BEHAVIORAL: pre-habilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Self-filling Osmotic Tissue Expander in Augmenting Keratinized Tissue Around Dentulous Region
Status: COMPLETED
Conditions: Soft Tissue Augmentation
Interventions: DEVICE: Osmed® hydrogel expander implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of IBI362 in Chinese Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: IBI362|OTHER: placebo|OTHER: Dulaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Status, Disease Specific and Quality of Life Outcomes in Patients With Cutaneous Lupus
Status: TERMINATED
Conditions: Cutaneous Lupus Erythematosus
Interventions: DIETARY_SUPPLEMENT: vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Imipenem Prophylaxis in Patients With Acute Pancreatitis
Status: COMPLETED
Conditions: Acute Pancreatitis
Interventions: DRUG: Imipenem|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Pembrolizumab (MK-3475) Plus Docetaxel Versus Placebo Plus Docetaxel in Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-921/KEYNOTE-921)
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Docetaxel|DRUG: Prednisone|DRUG: Placebo|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation for Post-COVID-19 Syndrome Through a Supervised Exercise Intervention
Status: COMPLETED
Conditions: Covid19|Post-COVID-19 Syndrome
Interventions: BEHAVIORAL: Exercise|BEHAVIORAL: Inspiratory muscle training|BEHAVIORAL: Controls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ibrutinib for the Treatment of COVID-19 in Patients Requiring Hospitalization
Status: COMPLETED
Conditions: Aplastic Anemia|Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm|Monoclonal B-Cell Lymphocytosis|Monoclonal Gammopathy of Undetermined Significance|Myelodysplastic Syndrome|Symptomatic COVID-19 Infection Laboratory-Confirmed
Interventions: OTHER: Best Practice|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Adjuvant to General Anesthesia of Abdominal Hysterectomy
Status: UNKNOWN
Conditions: Effect of Drugs
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phenytoin as a Neuroprotective Agent Against Corticosteroid-induced Functional Imaging Changes
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Phenytoin (brand name Dilantin)|DRUG: Hydrocortisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate if Sucking a Coldamaris Lozenge Elutes Sufficient Iota-carrageenan to Inactivate Usual Common Cold Viruses
Status: COMPLETED
Conditions: Common Cold|Viral Infection
Interventions: DEVICE: Coldamaris lozenges
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Clinical Study of Apatinib for the 2nd Treatment of Esophageal Cancer or Esophageal and Gastric
Status: UNKNOWN
Conditions: Esophagus Cancer, Stage III|Esophageal Gastric Cardia Type Metaplasia|Esophagus Cancer, Stage IV
Interventions: DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING